cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pharmacovigilance insights into drug-induced cystitis: analysis of FDA data from 2004 to 2024
Creators: name: Zheng, Fuchun
name: Yang, Xin
name: Li, Sheng
name: Yuan, Yuyang
name: Wang, Zhipeng
name: Xiong, Situ
name: Fu, Bin
name: Liu, Wei
name: Lu, Qi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Drug-induced cystitis (DIC) significantly impacts patient quality of life and treatment outcomes. This study investigates the incidence and characteristics of DIC using data from the FDA Adverse Event Reporting System (FAERS). We reviewed FAERS reports related to cystitis from Q1 2004 to Q1 2024, compiling a list of potential causative drugs. The top 50 drugs with the highest number of cystitis reports were ranked. Statistical disproportionality analyses, including Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR), were used to detect unusually high reporting frequencies of cystitis associated with specific drugs. From 17,703,515 FAERS reports spanning 2004–2024, 36399 involved cystitis. The majority of implicated drugs were antineoplastics. Busulfan, BCG, and mitomycin had the highest ROR and PRR values. Additionally, drugs such as defibrotide sodium, milrinone, and dyazide, which do not have cystitis listed on their labels, were identified, highlighting the need for increased clinical vigilance and awareness. The findings underscore the importance of ongoing pharmacovigilance in identifying and characterizing DIC. Further clinical studies are warranted to validate these associations and to develop strategies for mitigating the risk of DIC, thereby improving patient safety and treatment outcomes.
Políticas de subsistencia que sugiere el COVID–19
Creators: name: Suing, Abel
Publisher: name: Zenodo
Year: 2020
Subjects: COVID-19
prevención
sanidad
periodistas
Políticas
subsistencia
catástrofe
inequidad
economía

description: Participación como editorialista en el informativo de la mañana, de 6:30 a 8:00, de Radio Loja, 97.7, que se emite desde la ciudad de Loja en Ecuador.
How Media Resources and Power Relations Define Critical Reporting in China: A Longitudinal Analysis of The Beijing News’ Corruption Coverage Between 2004 and 2018
Creators: name: Hu, Yang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Critical reporting (piping-baodao) has long been considered one of the most important journalistic tools in China, exhibiting great democratic potential. However, the media environment for such reporting has become precarious over the past decade, raising the questions of how much space is left for critical reporting and how it is related to the media–state dynamics. Drawing on a 15-year longitudinal content analysis of how The Beijing News—an outspoken newspaper—reported corruption, this study explored the evolution of critical reporting in China. The results revealed that critical reporting is still a small-scale, non-routine journalistic practice. A detailed analysis was conducted to determine how media resources and power relations shaped critical reporting. The results showed that critical reporting has tended to take a resource-intense format and require non-official sources. Furthermore, critical reporting was more pronounced with respect to the coverage of low-ranking officials and officials outside the newspaper’s parent region. Broader implications of these findings have been discussed. Overall, the present study advances the understanding of critical journalism in an authoritarian context and explores its relations with the state.
POSITIONS OF METAPHORS IN A LITERARY TEXT
Creators: name: Karjawbaev, Orazali
name: Toleubayeva, A.O.
Publisher: name: Zenodo
Year: 2024

description: In order to identify the parallels and contrasts between the two texts, this article compares the pragmatic use of English metaphor in political documents with that in literary literature. Moreover, it aims to incorporate the three most popular perspectives on metaphor, namely the pragmatic, semantic, and cognitive perspectives
Association between ambient temperature and varicella among adults in Qingdao, China during 2008-2019
Creators: name: Wang, Zixuan
name: Li, Xiaofan
name: Li, Shanpeng
name: Guan, Jing
name: Hu, Ping
name: Wang, Wencheng
name: Yang, Feng
name: Zhang, Dongfeng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Little concern has been paid to the relationship between temperature and varicella among adults. Daily meteorological data and varicella cases in Qingdao among adults from 1 January 2008 to 31 December 2019 were collected. A combination of quasi-Poisson generalized additive model (GAM) and distributed lag non-linear model (DLNM) was conducted to assess the temperature-lag-varicella relationship. We also estimated the lag-response curves for different temperatures and the exposure-response relationships for different lag days. The number of varicella cases was 10,296. Compared with the minimum-varicella temperature (25°C), we found the largest effect of temperature on varicella within 21 lag days was at 1°C (RR, 6.72; 95% CI, 2.90–15.57), and then the effect declined as the temperature increased. A similar trend of rising first and then falling was found in temperature-response curves for different lag days. A reverse U-shape lag pattern was found for different levels of temperatures. Temperature may affect varicella.
Paper Analisis Negocio Electrico Asociado a Embalses.pdf
Creators: name: Zuniga, Paolo
Publisher: name: figshare
Year: 2016
Subjects: subject: 91305 Energy Generation, Conversion and Storage Engineering
subject: FOS: Mechanical engineering
subject: 99902 Engineering Instrumentation
subject: FOS: Other engineering and technologies
subject: 90701 Environmental Engineering Design
subject: FOS: Environmental engineering
subject: 90608 Renewable Power and Energy Systems Engineering (excl. Solar Cells)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper assessments of hydropower projects associated with existing irrigation reservoirs and projected in Chile they took place. Regulatory, technical and economic feasibility was also analysed, considering the potential contributions to a problem associated with the restrictions imposed by the multiple use of generation and irrigation. They also found that the results do not affect economic indicators and feasibility of the joint venture. The conclusions of this work will serve to review the set of energy and irrigation business, at a time when both markets separately present dilemmas and problems to advance the development of infrastructure of reservoirs, delaying works necessary for future development. Keywords: Irrigation Business, Electrical Business, Dams, Hydropower, joint venture.
Where to start: Use of the bilingual multidimensional ability scale (B-MAS) to identify developmental language disorder (DLD) in bilingual children
Creators: name: Wang, Danyang
name: Choi-Tucci, Alexander
name: Mendez-Perez, Anita
name: Gillam, Ronald B.
name: Bedore, Lisa M.
name: Peña, Elizabeth D.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: The identification of developmental language disorder (DLD) is challenging for clinicians who assess bilinguals. This paper introduces a protocol-based approach, the Bilingual Multidimensional Ability Scale (B-MAS), for expert raters to identify DLD in bilinguals. Three bilingual speech-language pathologists (SLPs) reviewed 166 Spanish-English bilingual children’s profiles, which included performance on direct (morphosyntax, semantics, and narrative tasks) and indirect (parent/teacher survey) measures in both languages. A multidimensional scale (0–5) was adopted to rate children’s performance. A diagnosis of DLD was made if at least two raters assigned a summary rating of ≤2. Analysis of the scores on the B-MAS resulted in the identification of 21 children as having DLD. Though different strategies were employed to make decisions, the three SLPs demonstrated high inter-rater agreement across different ratings (intraclass correlation coefficient values ranged from .83 to .90). For bilingual populations that are understudied and for which gold standards of assessment are not available, the B-MAS can be adopted as a starting point to study DLD or as a reference standard to develop new assessment tools in that population. Clinically, this protocol could be tailored and evaluated by a group of SLPs serving a large population of a particular bilingual group for diagnostic purposes.
Post-marketing safety concerns with abrocitinib: a real-world pharmacovigilance analysis of the FDA adverse event reporting system
Creators: name: Zhu, Zhou
name: Liu, Mingjuan
name: Zhang, Hanlin
name: Zheng, Heyi
name: Li, Jun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine

description: Abrocitinib was newly approved for treatment of moderate-to-severe atopic dermatitis. The present study was to assess abrocitinib-related adverse events (AEs) using the Food and Drug Administration Adverse Event Reporting System (FAERS). Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) algorithms, were employed to quantify the signals of abrocitinib-related AEs. A total of 3,177,744 reports of AEs were collected from the FAERS database, of which 1370 reports were identified with abrocitinib as the primary suspect drug. Abrocitinib-induced adverse events (AEs) occurred across 27 system organ classes (SOCs). A total of 68 preferred terms (PTs) with significant disproportionality, meeting the criteria of all four algorithms simultaneously, were identified. Unexpected significant AEs, such as increased blood cholesterol, venous embolism, hypoacusis, cellulitis, and tuberculosis, might also occur. The median onset time for abrocitinib-associated AEs was 182 days (interquartile range [IQR] 47–527 days). The results of this study were consistent with clinical observations. Additionally, unexpected safety signals for abrocitinib were identified, which provided supportive information for the safety profile of abrocitinib. Prospective clinical studies are warranted to validate these findings.
Identifying developmental language disorder (DLD) in multilingual children: A case study tutorial
Creators: name: Hamdani, Saboor
name: Chan, Angel
name: Kan, Rachel
name: Chiat, Shula
name: Gagarina, Natalia
name: Haman, Ewa
name: Łuniewska, Magdalena
name: Polišenská, Kamila
name: Armon-Lotem, Sharon
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: A long-standing issue in identifying developmental language disorder (DLD) in multilingual children is differentiating between effects of language experience and genuine impairment when clinicians often lack suitable norm-referenced assessments. In this tutorial we demonstrate, via a case study, that it is feasible to identify DLD in a multilingual child using the CATALISE diagnostic criteria, Language Impairment Testing in Multilingual Settings (LITMUS) assessment tools, and telepractice. This tutorial features a case study of one 6-year-old Urdu-Cantonese multilingual ethnic minority child, and seven age- and grade-matched multilinguals. They were tested via Zoom using Urdu versions of the Multilingual Assessment Instrument for Narratives (LITMUS-MAIN), the Crosslinguistic Lexical Task (LITMUS-CLT), the Crosslinguistic Nonword Repetition Test (LITMUS-CL-NWR), and the Sentence Repetition Task (LITMUS-SRep). The child scored significantly lower in the LITMUS tests compared to her peers in her best/first language of Urdu. Together with the presence of negative functional impact and poor prognostic features, and absence of associated biomedical conditions, the findings suggest this participant could be identified as having DLD using the CATALISE diagnostic criteria. The result demonstrates the promise of this approach to collect reference data and identify DLD in multilingual children. The online LITMUS battery has the potential to support identification of multilingual DLD in any target language.
Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies
Creators: name: Taranto, Alex Gutterres
name: Sônia Carine Cova Costa
name: Leite, Franco Henrique Andrade
name: Matheus Santos De Sá
name: Soares, Milena Botelho Pereira
name: Mussi, Miriam Moreira
name: Alexsandro Branco
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: The antiplasmodial active extract of Xanthium cavanillesii contains 3,4-dicaffeoyl quinic acid (3,4-DCQA), 3,5-dicaffeoyl quinic acid (3,5-DCQA) and 1,3,5-tricaffeoyl quinic acid (1,3,5-TCQA). These results inspired us to investigate the interaction of these molecules with a promising validated target of Plasmodium, PfATP6 orthologue of mammalian Ca+2-ATPase. Models of this receptor were obtained through comparative modelling. Afterwards, molecular docking studies were used to identify possible interaction modes of these caffeoyl quinic derivatives on the binding site. The 1,3,5-TCQA had the best energy, but all of these had better energy than thapsigargin, a non-competitive inhibitor of the sarco/endoplasmatic reticulum Ca+2-ATPase (SERCA).
Futures of Learning: Speculative Design Toolkit
Creators: name: Lab, SWISP
name: COLEMAN, KATHRYN
name: HEALY, SARAH
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390307
subject: Teacher education and professional development of educators
classificationCode: 330306
subject: Design practice and methods
classificationCode: 390102
subject: Curriculum and pedagogy theory and development
classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy

description: The Futures of Learning Speculative Design Toolkit arises from the urgent need for innovative models of community-based education that explore human-land-technology relationships as collective expression and mobilisation of knowledge. This project engages with grand challenges affecting young people, particularly those associated with the climate crisis and intensified use of digital technologies which can both mitigate and contribute to ecological collapse. We ask what role does speculative design education play in this space? Speculative design is sometimes called critical design or design fiction which requires zooming out beyond user-centred design and asks what the effects of the designs could be on future societies. It’s concerned with possibilities, not probabilities, pushing people to consider their preferences over a set of possible futures and the ways in which objects are designed, help or hinder their attempts to build those futures. We will be hacking the Futures of Learning and will take as its starting point The Anthropocene Curriculum (2021) developed with Science Gallery Bengaluru through the ‘2020 The Shape of Practice Seminar’ (https://www.anthropocene-curriculum.org/project/the-shape-of-a-practice). The project began at the Future Design Research Symposium in September 2022 and was followed by a 2-day hackathon in 2023 guided by the following questions to encourage creative risk-taking in the interest of generating new knowledge through lived experience:  
What might be the futures of learning?  What if mobile technologies were used as an expansive medium for creative problem-solving and social justice for the futures of learning?  How might it spark new ideas for intercultural climate futures and drive systemic change in design education?  Launched in early 2024, the Speculative Co-Design Toolkit and online curriculum is an educational adventure, inviting design teachers and students alike to delve into the realm of speculation, transcending the boundaries of the present now to envision tomorrows to come. Kate Coleman, the Chief Instigator of the project sought funding for this work because she saw the need to raise the profile of design education, particularly speculative design. Kate wanted to support design teacher education and work in partnership with teachers and young people to encourage imagination to flow freely about learning in a post-covid world. She was thrilled to have the project funded by the Creative Futures Design Research and Education Fund at the University of Melbourne.
RhIII-catalyzed annulation of N-methoxyindozamides with heterobicyclic alkenes towards indolo[3,2-c]heteroarenes
Creators: name: Li, Ping
name: Wang, Jiancheng
name: Li, Han
name: Dong, Wanrong
name: Peng, Zhihong
name: An, Delie
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology

description: A rhodium-catalyzed annulation protocol towards indolo[3,2-c]-1-azaanthraenes and successive treatment with different acids, which offered diverse indolo[3,2-c]-heteroarenes, were herein demonstrated. The transition metal-mediated system offered a direct and facile approach towards the heterocyclic compounds of great significance, enjoying high efficiency and good functional groups compatibility. An annulation reaction between N-methoxyindozamides and heterobicyclic alkenes was herein disclosed. The Rh-Ag-cocatalyzed system offered a direct approach towards various indolo[3,2-c]-1-azaanthraenes in high efficiency and good functional group tolerance. Successive treatment of acids gave different products of great importance.
Carnet nº 7b, commencé à Tsin-tsi-kar (p. 45)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 25-6-1930
Combining executive function training and anomia therapy in chronic post-stroke aphasia: A preliminary study of multidimensional effects
Creators: name: Bontemps, Mélanie
name: Servières-Bordes, Marion
name: Moritz-Gasser, Sylvie
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Virology

description: The influential relationship between executive functioning and aphasia rehabilitation outcomes has been addressed in a number of studies, but few have studied the effect of adding executive function training to linguistic therapies. The present study aimed to measure the effects of combining, within therapy sessions, executive function training and anomia therapy on naming and discourse abilities in people with chronic aphasia. A single-case experimental design with multiple baselines across participants was used. Four persons with chronic post-stroke aphasia received 12 sessions of a tailored treatment combining executive function training and semantic feature analysis (SFA) therapy. Naming accuracy of treated items was examined over the course of the treatment while control naming scores of untreated items and discourse measures were collected pre-treatment, immediately post-treatment, and 4 weeks post-treatment, in order to investigate the multidimensional effects of the treatment and their maintenance. Naming skills improved in all participants for treated and untreated items, were maintained over time, and were accompanied by improved discourse abilities. Visual and statistical analyses showed a significant treatment effect for naming skills in three out of the four participants. A combination of executive function training and SFA treatment in people with chronic aphasia may improve both naming skills and discourse efficiency. Further studies are needed to substantiate these promising preliminary results.
Miscellanea
Creators: name: Williams, W J
Publisher: name: Archaeology Data Service
Year: 2018

description: Journal of the Chester Archaeological Society, 28 (2), 216-219
description: Short article describing the discovery of a Roman cremation burial during road construction to the east of Eaton Road at Chester. A silt deposit similar to one noted by the author during investigations in a nearby garden two years previously was observed in association with a rubble foundation. Subsequent excavations to the north of the burial revealed another cremation burial in an urn of 1st century date and parts of two further urns. The rubble foundation perhaps supported a boundary wall or a row of tombstones. LD
Grammar intervention using graduated input type variation (GITV) for pre-primary children: A single-case experimental design study
Creators: name: Wong, Anita M.-Y.
name: Sou, Hannah H.-I.
name: Ip, Lexi H.-T.
name: Chiu, Catherine H.-K.
name: Au, Cecila W.-S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study examined the early efficacy of a new theory-driven principle of grammar intervention, graduated input type variation (GITV). Three Cantonese-speaking children, aged between 4;01 and 5;10, with oral language difficulties participated in this single baseline within-participant single case experimental study. The children received a total of 300 teaching episodes of the target serial verb construction via focused stimulation and recast over 10 30- to 45-minute sessions. The 30 exemplars of the target included low type variation of the verbs in each of the first five sessions, followed by high type variation in the remaining sessions. Visual analysis revealed that all children improved their performance in the target construction but not the control vocabulary in the probes, suggesting a treatment effect. Maintenance of treatment effects was also observed in all children. Positive results in across-behaviour generalisation to the untrained construction were observed in all children. Generalisation to other less structured linguistic contexts and to the narrative retell discourse context was minimal and observed in one child only. Preliminary evidence suggested early efficacy of GITV as a principle for grammar intervention. Modifications in the research methodology are recommended for future studies involving children with developmental language disorder.
Detection and analysis of the safety profile of talazoparib based on FAERS database
Creators: name: Tang, Mufei
name: Liu, Peiyan
name: Du, Linzhe
name: Li, Yuanyuan
name: Chen, Jinjin
name: Li, Yang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Talazoparib was approved for the treatment of breast cancer. However, the safety of talazoparib in a large population sample over an extended period remained uncertain. The objective of this study is to offer guidance for the secure utilization of talazoparib in clinical settings. Four algorithms were used to quantify the signals of talazoparib associated adverse events(AEs), using data from the food and drug administration adverse event reporting system(FAERS) between fourth quater of 2018 and second quater of 2023. A total of 7,186,517 records were reported, with 737 indicating talazoparib as the primary suspected (PS) AEs. A total of 40 significant preferred terms (PTs) that adhere to the four algorithms were simultaneously retained. There is a possibility of experiencing unforeseen and noteworthy AEs, including embolism(0.46%), pulmonary embolism(1.06%), hyponatremia(0.46%), hypokalemia(0.40%), hematuria(0.33%), and pericardial effusion(0.26%). Most of the AEs related to talazoparib occurred within the initial month of starting the medication, with a median onset time of 79 days (IQR: 22–207 days). Results of our study were consistent with clinical observations, and we also found potential new and unexpected AEs signals for talazoparib, suggesting prospective clinical studies were needed to confirm these results and illustrate their relationship. Our results may provide valuable evidence for further safety studies of talazoparib.
title: Climate Trend Analysis Using Mann-Kendall and Sen’s Slope Estimator Tests in Central Luzon, Philippines
Creators: name: Shiella Mae H. Fajardo
Publisher: name: Phetchaburi Rajabhat University
publisherIdentifierScheme: ROR
Year: 2025
Subjects: Climate change
Trend analysis
Mann-Kendall
Sen’s Slope Estimator

description: Interdisciplinary Research Review (IRR), 20, 1, 21–31
Neuroimaging Findings in Stroke with Clinical Correlation
Creators: name: Mehta, Kanika
name: Verma, Sameer
name: Jha, Sumit
name: Rohit Sehrawat
Publisher: name: figshare
Year: 2016
Subjects: subject: 110903 Central Nervous System
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging

description: Abstract: Objective: This study was done to evaluate the neuroimaging findings in stroke and to correlate clinical findings with the neuroimaging findings. Methods : A prospective hospital based cohort study was done of 250 patients with provisional clinical diagnosis of recent stroke who underwent neuroimaging (CT/MR). Patients with neurologic deficit due to trauma, hypoxic injury or suspected substance abuse were excluded. Imaging findings were evaluated and tabulated independently and subsequently correlated with the clinical findings from the available patients records. Results : The study showed male predominance (male patients 59%) and maximum number of patients belonged to sixth decade (27.6 %). Infarcts (172 cases, 70%) were more common than hemorrhage (78 cases, 30%). Arterial infarcts (167 cases, 97 %) were predominant with involvement of MCA territory in 70 cases (39%). In cases of hemorrhagic stroke basal ganglia complex was the commonest location for hemorrhage (57 cases, 84 %). Clinical diagnosis in cases of ischemic stroke had Senstivity of 68%, Specificity 93 %, Positive Predective Value 96 % and Negative Predective Value 56 %. While in cases of hemorrahagic stroke the clinical diagnosis had sensitivity of 90.8%, Specificity 80.5%, Positive Predective Value 67% and Negative Predective Value 95.2 %. Conclusion: Ischemic stroke was more common than hemorrhagic stroke across all age groups. MCA territory infarcts and gangliothalamic bleed were the most common presentation in ischemic and hemorrhagic strokes respectively. There was significant concordance between clinical diagnosis and imaging findings. Clinical diagnosis had higher specificity for ischemic stroke while the sensitivity was higher for hemorrhagic stroke. Key words: Neuroimaging, Stroke, Clinico Radiological Correlation
The effects of symbolic gestural training on enhancing recovery of spoken naming in people with aphasia: A systematic review and meta-analysis
Creators: name: Zhang, Wei
name: Liao, Yi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: This study aimed to evaluate the effects of symbolic gestural training on enhancing recovery of spoken naming in people with aphasia (PWA) using a systematic review and meta-analysis. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, article search was conducted from four databases: Web of Science Core Collection, Medline, PsycINFO, and EBSCO. A total of 45 participants from four studies investigating the symbolic gestural training effects on PWA and outcome measures of spoken naming were included. The meta-analysis showed a medium overall effect of symbolic gestural training on enhancing recovery of spoken naming in PWA. Subgroup analysis also revealed that the training effect was more remarkable in the gesture + verbal training paradigm than in the gesture-only training paradigm. However, the differences in the training effects between short and long duration, and training supplied with and without feedback, were nonsignificant. This study illustrates the current state of the literature on symbolic gestural training in PWA, and serves as a reference for clinicians, patients, and health policy-makers regarding the application of symbolic gestural training in clinical or rehabilitation programs.
Dinuclear cadmium indomethacin and Lawsone complexes: synthesis, crystal structures, antiproliferative and biological evaluations
Creators: name: Tabrizi, Leila
name: Golbang, Reza
name: Sadeghi, Hamid
name: Chiniforoshan, Hossein
name: Mcardle, Patrick
name: Notash, Behrouz
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The synthesis and structural characterizations of Cd(II) indomethacin (Indo) and Lawsone (Law) complexes, K2[Cd2(Indo)4(SCN)2], 1 and [Cd2(Law)4(phen)2]·4CH3OH, 2 (SCN = thiocyanate, phen = 1,10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) and X-ray crystallography. The interaction of indomethacin and Lawsone ligands, 1 and 2 with calf thymus DNA and bovine serum albumin were investigated using UV–visible and fluorescence spectrophotometric methods. The in vitro cytotoxicity of 1 and 2 was examined against promyelocytic leukemia (HL-60), colon (HCT-8), brain (SF-295), and melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria were tested.
MPEC 2024-U242 : 2018 HL14
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2018 HL14

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease
Creators: name: Zhang, Chen
name: Zhou, Qian
name: Wu, Xu-Nian
name: Huang, Ya-Dan
name: Zhou, Jie
name: Lai, Zengwei
name: Wu, Yinuo
name: Luo, Hai-Bin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Phosphodiesterase-9 (PDE9) is a promising target for treatment of Alzheimer’s disease (AD). To discover multifunctional anti-AD agents with capability of PDE9 inhibition and antioxidant activity, a series of novel pyrazolopyrimidinone derivatives, coupling with the pharmacophore of antioxidants such as ferulic and lipolic acids have been designed with the assistance of molecular docking and dynamics simulations. Twelve out of 14 synthesised compounds inhibited PDE9A with IC50 below 200 nM, and showed good antioxidant capacities in the ORAC assay. Compound 1h, the most promising multifunctional anti-AD agent, had IC50 of 56 nM against PDE9A and good antioxidant ability (ORAC (trolox) = 3.3). The selectivity of 1h over other PDEs was acceptable. In addition, 1h showed no cytotoxicity to human neuroblastoma SH-SY5Y cells. The analysis on structure-activity relationship (SAR) and binding modes of the compounds may provide insight into further modification.
Dinuclear cadmium indomethacin and Lawsone complexes: Synthesis, crystal structures, antiproliferative and biological evaluations
Creators: name: Tabrizi, Leila
name: Golbang, Reza
name: Sadeghi, Hamid
name: Chiniforoshan, Hossein
name: Mcardle, Patrick
name: Notash, Behrouz
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The synthesis and structural characterizations of Cd(II) indomethacin (Indo) and Lawsone (Law) complexes, K2[Cd2(Indo)4(SCN)2], 1 and [Cd2(Law)4(phen)2]·4CH3OH, 2 (SCN = thiocyanate, phen = 1,10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) and X-ray crystallography. The interaction of indomethacin and Lawsone ligands, 1 and 2 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were investigated using UV-visible and fluorescence spectrophotometric methods. The in vitro cytotoxicity of 1 and 2 was examined against promyelocytic leukaemia (HL-60), colon (HCT-8), brain (SF-295), and melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria were tested.
Speculative Design Toolkit: Speculative Practice Architectures
Creators: name: Lab, SWISP
name: COLEMAN, KATHRYN
name: HEALY, SARAH
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy
classificationCode: 330306
subject: Design practice and methods
classificationCode: 390306
subject: Secondary education

description: Speculative design is sometimes called critical design or design fiction which requires zooming out beyond user-centred design and asks what the effects of the designs could be on future societies. It’s concerned with possibilities, not probabilities, pushing people to consider their preferences over a set of possible futures and the ways in which objects are designed, help or hinder their attempts to build those futures.The Speculative Design Toolkit: Speculative Practice Architectures are developed from years of teaching, co-designed knowledge from SWISP Lab Hackathons underpinned by 'Critical Design' theories, 'Speculative Design' and 'Theories of Practice Architectures' (Kemmis). Speculative Design is one of the most exciting ways for designers to practice problem solving by design. Critical design is critical thought translated into materiality. It is about thinking through design rather than through words and using the language and structure of design to engage people. When intertwined and folded within each other they offer new ways of doing, knowing and being.The Speculative Design Toolkit: Speculative Practice Architectures include:Scenario buildingBackcasting - FuturecastingArtefacts form the FutureFutures TanglegrammingFictional Narratives
title: Analyzing Drought Risks and Impacts in the Kok River Basin
Creators: name: Mongkonkorn Srivichai
Publisher: name: Phetchaburi Rajabhat University
publisherIdentifierScheme: ROR
Year: 2025
Subjects: Drought Risk
SPI
2P2R Framework
Climate Variability
Kok River Basin

description: Interdisciplinary Research Review (IRR), 20, 1, 32-41
MetadataS1 (1).docx
Creators: name: Alves, Carolina
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310301
subject: Behavioural ecology

description: The continuous growth of the urban population, coupled with habitat loss, has resulted in unanticipated interactions between animals and humans in urban centers. In this study, we investigated the presence of mammals in urban centers through newspaper reports on websites. Specifically, we examined: i) the frequency of photographic records, ii) the temporal trends (2001 to 2021) and spatial trends (Brazilian regions and states) of the records, iii) the orders, families, and species most frequently reported in urban centers. We searched for news on the Google platform (http://www.google.com.br). We employed combinations of the keywords "mammals in urban centers," "mammals found in the city," and "mammal found in the municipality." We excluded repeated news items, sites that experienced technical problems during the search period, and those that did not cover the topic. We compiled a total of 733 websites. Of the total number of sites, 89% (n = 652) had photographic records. The records spanned from 2002 to 2021, with 73% (n = 534) occurring in the last four years. The Southeast (41%, n = 302), South (25%, n = 182), and Midwest (18%, n = 129) regions stood out. The animals recorded belonged to 55 mammal species (16 vulnerable and 3 endangered), distributed in 22 families and 10 orders. This is the first study that utilize websites for diagnosing the mammal fauna present in urban centers in Brazil. The dataset generated here could aid in understanding the occurrence of mammal species in the urban environment.
Speculative Design Toolkit: Speculative Practice Architectures
Creators: name: Lab, SWISP
name: COLEMAN, KATHRYN
name: Healy, Sophia
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy
classificationCode: 330306
subject: Design practice and methods
classificationCode: 390306
subject: Secondary education

description: Speculative design is sometimes called critical design or design fiction which requires zooming out beyond user-centred design and asks what the effects of the designs could be on future societies. It’s concerned with possibilities, not probabilities, pushing people to consider their preferences over a set of possible futures and the ways in which objects are designed, help or hinder their attempts to build those futures. The Speculative Design Toolkit: Speculative Practice Architectures are developed from years of teaching, co-designed knowledge form SWISP Lab Hackathons underpinned by Critical Design theories, Speculative Design and Theories of Practice Architectures (Kemmis). Speculative Design is one of the most exciting ways for designers to practice problem solving by design. Critical design is critical thought translated into materiality. It is about thinking through design rather than through words and using the language and structure of design to engage people. When intertwined and folded within each other they offer new ways of doing, knowing and being. The Speculative Design Toolkit: Speculative Practice Architectures include: Scenario building Backcasting - FuturecastingArtefacts form the FutureFutures Tanglegramming Fictional Narratives
Characterization of Focal Hepatic Lesions: A Comparative Study of Ultrasound versus Computed Tomography item
Creators: name: Jain, Garima
name: Verma, Sameer
name: Bansal, Rani
name: PK Gupta
name: Vibhu Garg
Publisher: name: figshare
Year: 2016
Subjects: subject: 110320 Radiology and Organ Imaging
subject: FOS: Clinical medicine
subject: 110307 Gastroenterology and Hepatology

description: Introduction: Focal Hepatic Lesionsare common findings as a result of the ever increasing use of imaging techniques in patients with nonspecific abdominal complaints. This study was undertaken to compare unenhanced ultrasound versus computed tomographyin evaluation of patients with focal hepatic lesions. Methods: In this study, 100 cases of focal hepatic lesions were studied with USG and CECT abdomen. Imaging findings were evaluated and tabulated and correlated with the clinical findings, histopathological findings andfollow up. The findings were checked and statistically tabulated . Results: Out of a total 100 patients included for study, most patients were in age range of 41 – 60 years. Males : females ratio was 64 : 36. 23.0% patients were smokers, 15.0% patients were alcoholic. We studied approximately 233 focal liver lesions with 120 lesions being true benign and 113 lesions being true malignant.Sensitivity (%) of diagnosing benign lesions on USG was 94.44% and on CT was 97.43%, for malignant lesions it was 89% and 97%respectively. Specificity(%) of diagnosing benign lesions on USG was 98.45% and on CTwas 100%, for malignant lesions it was 94.65 and 98.51% respectively. Conclusion: Focal liver lesions remain a diagnostic challenge. These lesions are frequently caused by common benign, malignant and metastatic etiologies. We conclude that USG plays an important role as an initial screening modality and as an adjunct to CECT and Triphasic CT in the evaluation of focal hepatic lesions.
title: Synthesizing Maritime Interaction Scenarios for Testing Autonomy
Creators: name: Hargis, Benjamin E.
name: Papelis, Yiannis E
Publisher: name: Old Dominion University Libraries
Year: 2022

description: This paper presents a method to deterministically synthesize maritime traffic interactions that can be presented to a system under test regardless of the state of the system under test. A background to the problem is given and the method is briefly outlined. Results indicate that the approach can enable more robust evaluation of maritime autonomous algorithms.
Multicomponent synthesis and anticancer activity studies of novel 6-(Trifluoromethyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives
Creators: name: Valeru, Anil
name: Luo, Zhi-Bin
name: Khan, Imran
name: Liu, Bin
name: Sngepu, Bhavanarushi
name: Godumagadda, Narender Reddy
name: Xu, Yin
name: Xie, Jimin
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: A series of novel 6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were obtained in good yields from ethyl 4,4,4-trifluoro-3-oxobutanoate, urea, and aryl aldehyde via Biginelli multicomponent reaction. All the corresponding products 4a–4p were examined against four human cancer cell lines (A549, HepG2, COLO205 and DU145) and compounds 4e, 4i, and 4 m which showed promising anticancer activity have been identified.
Piecewise Mixture Modeling for Longitudinal Virologic Data With Heterogeneity, Nonnormality, and Missingness
Creators: name: Yangxin Huang
name: Chunning Yan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: It is a common practice to analyze complex longitudinal data that arise frequently in medical studies that use nonlinear mixed-effects (NLME) or nonparametric mixed-effects (NPME) models. However, the following issues may stand out in AIDS longitudinal data analysis: (i) In clinical practice, the profile of each subject’s virologic response may follow a “broken stick” like trajectory, indicating multiple phases of decline and increase in response. Such multiple phases (with change-points) may be an important indicator to help quantify treatment effect and improve management of patient care. To estimate change-points, NLME or NPME models become a challenge due to complicated structures of model formulations. (ii) A homogeneous population assumption in models may be unrealistically obscuring important features of between- and within-subject variations. (iii) Normality assumption for model errors may not always give robust and reliable results, in particular, if the data exhibit nonnormality. And (iv) the responses may be missing and the missingness may be nonignorable. When statistical inference is carried out in such settings, it is important to account for the effects of these data features; otherwise, erroneous or even misleading results may be produced. Inferential procedures can be complicated dramatically when data with heterogeneous, nonnormal (skewed) and missing characteristics are observed in conjunction with change-points as unknown parameters into models. There has been relatively little study concerning all these features simultaneously. There is a need to fill up this gap as longitudinal data do often have these features. In this article, our objectives are to study simultaneous impact of these data features by developing Bayesian modeling approach-based finite mixture of hierarchical change-point (FMHC) models with skew distributions, allowing estimates of both model parameters and class membership probabilities at population and individual levels. An HIV/AIDS clinical data example is analyzed to demonstrate the proposed methodologies, and to compare various scenarios-based potential models. Supplementary materials for this article are available online.