cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of a Two-Stage Radial Inflow Turbine for a Mini-ORC
Creators: name: Heylen, Martin
name: Lemort, Vincent
name: Delanaye, Michel
name: Hillewaert, Koen
Publisher: name: Société Française de Thermique
Year: 2023
Subjects: ORC
Turbine
Energy

description: Many industrial processes suffer energy loss in the form of wasted thermal energy. In the current context of the energy crisis, it is important to improve the global efficiency of energy systems by converting this wasted thermal energy into useful energy (such as hot water for heating systems) or generating electricity. For this second purpose, Organic Rankine Cycle (ORC) has been developed. An ORC is a variant of the classical Rankine Cycle (RC) that uses an organic compound instead of water as the working fluid. Compared with the steam-based RC, the ORC can handle low-temperature thermal heat sources. This paper focuses on the development of a mini-ORC (power generation range: 5-50 kWe) fed by a low-temperature heat source (<150$^{\circ}$C) where a radial inflow turbine has been chosen for the expansion process. The ORC is developed to allow the coupling with a 10kWe Regenerative Gas Turbine (RGT) developed by Mitis. The RGT's turbogenerator is composed of a centrifugal compressor and a radial inflow turbine. To ensure rotor stability, it is relying on foil-bearing technology. In this work, the pump performs the compression of the liquid fluid before being evaporated within the evaporator. The turbogenerator configuration described above has then been converted into a two-stage turboexpander by integrating two radial turbine wheels. The use of a radial inflow turbine in a mini-ORC brings multiple challenges. Most pressurized working fluids have a very high density at the expander entrance. This results in a very small impeller size, which would lead to a relatively high impact of leakage losses between the blade tip and the shroud. Moreover, the low sound speed of sound of most working fluids leads to lower allowable rotation speeds and therefore lower work capacity of the turbine. Consequently, it is a necessity to select working fluids that have lower densities and speed of sound. One family corresponding to these criteria is the family of hydrocarbons. To have the possibility to perform several radial inflow turbine designs for a selection of working fluids, a model of the ORC and a 0-D design model of a radial turbine have been developed. The design software is based on the velocity triangles theory and predicts part of the flow physics within the turbine impeller. In comparison with the currently available radial turbine design software, this model does not rely on ideal gas law and properties but integrates a library to correctly account for the complex equations of state for organic fluids. Finally, 3-D CFD simulations of one of the designed turbines are performed to validate the design strategy and evaluate the off-design performances.
Dynamical chiral symmetry breaking in sliding nanotubes
Creators: name: Zhang, X. H.
name: Santoro, G. E.
name: Tartaglino, U.
name: Tosatti, E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We discovered in simulations of sliding coaxial nanotubes an unanticipated example of dynamical symmetry breaking taking place at the nanoscale. While both nanotubes are perfectly left-right symmetric and nonchiral, a nonzero angular momentum of phonon origin appears spontaneously at a series of critical sliding velocities, in correspondence with large peaks of the sliding friction. The non-linear equations governing this phenomenon resemble the rotational instability of a forced string. However, several new elements, exquisitely "nano" appear here, with the crucial involvement of Umklapp and of sliding nanofriction.
description: To appear in PRL
Quantization in classical mechanics and reality of Bohm's psi-field
Creators: name: Rusov, V. D.
name: Vlasenko, D. S.
name: Mavrodiev, S. Cht.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Based on the Chetaev theorem on stable dynamical trajectories in the presence of dissipative forces, we obtain the generalized condition for stability of Hamilton systems in the form of the Schrodinger equation. It is shown that the energy of dissipative forces, which generate the Chetaev generalized condition of stability, coincides exactly with the Bohm "quantum" potential. Within the framework of Bohmian quantum mechanics supplemented by the generalized Chetaev theorem and on the basis of the principle of least action for dissipative forces, we show that the squared amplitude of a wave function in the Schrodinger equation is equivalent semantically and syntactically to the probability density function for the number of particle trajectories, relative to which the velocity and the position of the particle are not hidden parameters. The conditions for the correctness of the Bohm-Chetaev interpretation of quantum mechanics are discussed.
description: 16 pages, significant improvement after 0806.4050 and 0804.1427. (v2) revised and reconsidered conclusions
Computing in Jacobians of projective curves over finite fields
Creators: name: Bruin, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11G20, 14G15, 14H50, 14Q05

description: We give algorithms for computing with divisors on projective curves over finite fields, and with their Jacobians, using the algorithmic representation of projective curves developed by Khuri-Makdisi. We show that many desirable operations can be done efficiently in this setting: decomposing divisors into prime divisors; computing pull-backs and push-forwards of divisors under finite morphisms, and hence Picard and Albanese maps on Jacobians; generating uniformly random divisors and points on Jacobians; computing Frobenius maps and Kummer maps; and finding a basis for the $l$-torsion of the Picard group, where $l$ is a prime number different from the characteristic of the base field.
description: 42 pages
Simulation massivement parallèle de la convection thermique dans la grotte de Lascaux
Creators: name: Salmon, Fabien
name: Lharti, Habiba
name: Lacanette, Delphine
name: Sirieix, Colette
Publisher: name: Société Française de Thermique
Year: 2023
Subjects: Simulation
convection
Lascaux
frontières immergées
massivement parallèle

description: La conservation du patrimoine est une question primordiale pour l'Histoire humaine. La grotte de Lascaux est la plus célèbre grotte ornée en France et sa préservation s'inscrit dans cette démarche. Les altérations pariétales résultent principalement des phénomènes de condensation. La caractérisation fine des processus physiques à l'échelle de la paroi requiert dans un premier temps la compréhension de la circulation de l'air dans la cavité. Celle-ci résulte des différences de température entre les parois induites par la propagation de l'énergie extérieure dans le massif rocheux autour de la grotte. Les variations saisonnières de température conduisent ainsi à une convection thermique associée à un nombre de Rayleigh de l'ordre de 108. Étant intéressés par les processus proches paroi, il est nécessaire d'effectuer une simulation numérique précise de la convection, basée sur un maillage fin. La simulation de cette convection a donc été effectuée de la manière la plus fine possible compte tenu des capacités de calcul actuelles. Cette simulation a été réalisée avec le logiciel opensource de mécanique des fluides Notus CFD (développé à I2M), basé sur la méthode des frontières immergées. Cette méthode consiste à conserver un maillage cartésien et à immerger la géométrie sans ajuster le maillage aux frontières physiques. Conservant un maillage cartésien, le problème linéaire est représenté par une matrice bande, dont les termes non nuls se regroupent autour de la diagonale, et permet l'utilisation de librairies de résolution massivement parallèles, tel que HYPRE. A la suite d'un travail de développements numériques et d'optimisation, il a été possible de réduire les inconvénients intrinsèques de la méthode des frontières immergées appliquées à des géométries très complexes tout en conservant ses avantages. Avec un maillage composé d'environ 1 milliard de cellules de 1,5 cm de côté, trois heures de convection ont pu être simulées sur 11 000 cœurs du supercalculateur Irene-Rome pendant deux semaines. L'extrême finesse du maillage compte tenu de la taille importante de la grotte, nous permet d'atteindre le niveau d'une DNS dans les zones présentant des vitesses faibles. Ailleurs, des vitesses pouvant aller jusqu'à 20 \si{\centi\metre\per\second} ont été simulées, indiquant une convection thermique relativement importante. Le rôle moteur de la convection dans les processus de condensation pourra ainsi être étudié à partir de cette simulation.
Das Mitglied der Leopoldina HANS GALLWITZ und seine Auseinandersetzungen mit der Staatsmacht 1946 - 1958
HANS GALLWITZ, Member of Leopoldina, the German Academy of Natural Scientists
Creators: name: Gerstengarbe, Sybille
Publisher: name: Hallesches Jahrbuch für Geowissenschaften
Year: 1997
Subjects: subject: 000

description: Seit 1946 lehrte der Geologe HANS GALLWITZ in Halle und war an der Universität und in der Deutschen Akademie der Naturforscher Leopoldina engagiert tätig. Sowohl im Kollegenkreis der Fakultät als auch im Kreis der halleschen Leopoldinamitglieder war er sehr geschätzt und übernahm in beiden Institutionen wichtige Funktionen als Dekan der Mathematisch-Naturwissenschaftlichen Fakultät bzw. als Sekretär der Naturwissenschaftlichen Abteilung der Leopoldina. An der Universität kam er aus politischen Gründen in Konflikte. Eine erste große politische Auseinandersetzung mit der Universitätsleitung ergab 'sich 1953, als die FDJ (Freie Deutsche Jugend) eine Kampagne gegen die Studentengemeinde durchführte. 1958 wurde gegen GALLWITZ ein Disziplinarverfahren angestrengt, weil er einem jungen Studenten eine Westreise „unberechtigt“ befürwortet hatte. Ein weiterer Vorwurf erwuchs ihm aus seiner Mitgliedschaft im „Spirituskreis‘“ , der 1958 in einer außerordentlichen Senatssitzung verboten wurde. Der massive politische Druck, der auf GALLWITZ lastete, bewegte ihn dazu, eine Dienstreise nach Wien anzutreten, obwohl er nach ärztlichem Rat aus gesundheitlichen Gründen nicht hätte fahren sollen. Auf der Rückreise von der Tagung in Wien, wo er auch die Leopoldina vertreten hatte, starb HANS GALLWITZ.
description: After arriving in Halle in 1946, HANS GALLWITZ became an active member of the Martin-LutherUniversity and Leopoldina, the German Academy of Natural Scientists. He was valued by his colleagues in both institutions and held several important positions, including Dean of the University and Secretary of the scientific section of the Academy. He had political difficulties at the university, beginning in 1953, when the East German youth organization FDJ campaigned against students who established an ecclesiastical student group. In 1958, GALLWITZ was the object of a politically motivated disciplinary investigation, partly because of his association with the "Spiritus" group, which was dissolved in the same year by a special meeting of the academic senate of the university. Under political pressure, GALLWITZ attended a meeting in Vienna, despitepoor health and against his doctor's advice. He died on the return journey from Vienna.
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title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
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Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐ¾Ð¼Ð¿ÑÐµÑÑÐ¾ÑÑ ÑÐµÐ½ÑÑÐ¾Ð±ÐµÐ¶Ð½ÑÐµ
Ð§Ð¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ
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title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÐµÑÐ¸Ð¾Ð´Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð´Ð°Ð½Ð¸Ñ Ð´Ð»Ñ ÐÐ¾ÑÑ-Ð¿ÑÐ¾ÐµÐºÑÐ° Â«Ð­ÑÐ°Ð¶Ð¸Â»
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ¸ÐºÑÐ»Ð¸Ð½Ð°, ÐÐ²Ð³ÐµÐ½Ð¸Ñ
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Year: 2018
Subjects: ÐÑÑÐ¸ÑÐ»Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¼Ð°ÑÐ¸Ð½Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½ÑÐµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»ÑÐ½ÑÐµ
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GALEX and Optical Light Curves of WX LMi, SDSSJ103100.5+202832.2 and SDSSJ121209.31+013627.7
Creators: name: Linnell, Albert P.
name: Szkody, Paula
name: Plotkin, Richard M.
name: Holtzman, Jon
name: Seibert, Mark
name: Harrison, Thomas E.
name: Howell, Steve B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: {\it GALEX} near ultraviolet (NUV) and far-ultraviolet (FUV) light curves of three extremely low accretion rate polars show distinct modulations in their UV light curves. While these three systems have a range of magnetic fields from 13 to 70 MG, and of late type secondaries (including a likely brown dwarf in SDSSJ121209.31+013627.7), the accretion rates are similar, and the UV observations imply some mechanism is operating to create enhanced emission zones on the white dwarf. The UV variations match in phase to the two magnetic poles viewed in the optical in WX LMi and to the single poles evident in the optical in SDSSJ1212109.31+013627.7 and SDSSJ103100.55+202832.2. Simple spot models of the UV light curves show that if hot spots are responsible for the UV variations, the temperatures are on the order of 10,000-14,000K. For the single pole systems, the size of the FUV spot must be smaller than the NUV and in all cases, the geometry is likely more complicated than a simple circular spot.
description: 29 pages, 4 tables, 10 figures, Astrophysical Journal, accepted
IMPROVING ENVIRONMENTAL SUSTAINABILITY OF THE AGRO-FOOD SECTOR THROUGH THE APPLICATION OF THE LCA METHODOLOGY
Creators: name: FUSI, ALESSANDRA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Over the last years, the interest in the environmental impacts associated with food systems has strongly grown. Several works have confirmed the relative importance of ?food and beverages consumption? in contributing to environmental impacts. According to the United Nations Food and Agriculture Organisation, livestock accounts for 18% of the global greenhouse gas emissions. In the EU, food consumption accounts for 20-30% of various environmental impacts and, in the case of eutrophication, more than 50%. Consumers are now changing their behaviour to integrate environmental considerations into lifestyle choices. The environmental aspect is now one of the variables taken into consideration by consumers during the purchasing process. LCA provides a methodological framework, a supporting tool for evaluating and improving the environmental performance of food systems. Given the importance of the environmental aspects associated with goods production, and being food consumption one of the major causes for resource use and environmental impact by modern households, the focus of this work has been the application of the LCA methodology to agro-food products in order to: 1. Depict the environmental profile of some food products, identifying the environmental hotspots associated with their production; 2. Evaluate different technical solutions in a chain optimisation perspective The following products/processes have been evaluated: wine, cereals (maize, wheat, triticale and rice), fresh-cut salad, pasta cooking. The case studies presented in this work provide a clear demonstration of how LCA can be used on agro-food products to identify environmental hotspots and evaluate possible ameliorative solutions. In the light of increasing the sustainability of food production, it is in fact crucial, on the one hand, to measure the impacts produced by food products and identify the most critical phases on which intervene to obtain relevant improvements and, on the other hand, to quantify such improvements, assessing different alternative solutions.
The dissociation catastrophe in fluctuating-charge models and its implications for the concept of atomic electronegativity
Creators: name: Chen, Jiahao
name: Martinez, Todd J
Publisher: name: arXiv
Year: 2008
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We have recently developed the QTPIE (charge transfer with polarization current equilibration) fluctuating-charge model, a new model with correct dissociation behavior for nonequilibrium geometries. The correct asymptotics originally came at the price of representing the solution in terms of charge-transfer variables instead of atomic charges. However, we have found an exact reformulation of fluctuating-charge models in terms of atomic charges again, which is made possible by the symmetries of classical electrostatics. We show how this leads to the distinguishing between two types of atomic electronegativities in our model. While one is a intrinsic property of individual atoms, the other takes into account the local electrical surroundings. This suggests that this distinction could resolve some confusion surrounding the concept of electronegativity as to whether it is an intrinsic property of elements, or otherwise.
description: 17 pages, prepared for "Proceedings of QSCP-XIII" in Prog. Theor. Chem. Phys
Constructing 2D and 3D cluster states with photonic modules
Creators: name: Ionicioiu, Radu
name: Munro, William J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Large scale quantum information processing (QIP) and distributed quantum computation require the ability to perform entangling operations on a large number of qubits. We describe a new photonic module which prepares, deterministically, photonic cluster states using an atom in a cavity as an ancilla. Based on this module we design a network for constructing 2D cluster states and then we extend the architecture to 3D topological cluster states. Advantages of our design include a passive switching mechanism and the possibility of using global control pulses for the atoms in the cavity. The architecture described here is well suited for integrated photonic circuits on a chip and could be used as a basis of a future quantum optical processor or in a quantum repeater node.
Introducing the Photometric Maximum Likelihood Method: Galaxy Luminosity Functions at z<1.2 in MUSYC-ECDFS
Creators: name: Christlein, Daniel
name: Gawiser, Eric
name: Marchesini, Danilo
name: Padilla, Nelson
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a new maximum likelihood method for the calculation of galaxy luminosity functions from multi-band photometric surveys without spectroscopic data. The method evaluates the likelihood of a trial luminosity function by directly comparing the predicted distribution of fluxes in a multi-dimensional photometric space to the observations, and thus does not require the intermediate step of calculating photometric redshifts. We apply this algorithm to ~27,000 galaxies with m_R<=25 in the MUSYC-ECDFS field, with a focus on recovering the luminosity function of field galaxies at z<1.2. Our deepest LFs reach M_r=-14 and show that the field galaxy LF deviates from a Schechter function, exhibiting a steep upturn at intermediate magnitudes that is due to galaxies of late spectral types.
description: 24 pages, 11 figures, accepted for publication by MNRAS
title: ÐÐ³Ð½ÐµÑÑ Ð¡Ð¼ÐµÐ´Ð»Ð¸ - Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»Ñ ÐÐ¸ÑÐ°Ñ (Ð¿Ð¾ Ð°Ð½Ð³Ð»Ð¾- Ð¸ ÑÑÑÑÐºÐ¾ÑÐ·ÑÑÐ½ÑÐ¼ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ°Ð¼)
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ°ÐºÑÐ¸Ð¼Ð¾Ð²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÐµ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ
Ð¶ÑÑÐ½Ð°Ð»Ð¸ÑÑÐ¸ÐºÐ°
Ð¿ÑÐ°Ð²Ð° Ð¸ ÑÐ²Ð¾Ð±Ð¾Ð´Ñ Ð³ÑÐ°Ð¶Ð´Ð°Ð½
Ð¸ÑÑÐ¾ÑÐ¸Ñ ÐÐ¸ÑÐ°Ñ

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð°Ð¼ÐµÑÐ¸ÐºÐ°Ð½ÑÐºÐ¾Ð³Ð¾ Ð¶ÑÑÐ½Ð°Ð»Ð¸ÑÑÐ° ÐÐ³Ð½ÐµÑÑ Ð¡Ð¼ÐµÐ´Ð»Ð¸, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð° ÐÐ¸ÑÐ°Ð¹ Ð² Ð½Ð°ÑÐ°Ð»Ðµ-ÑÐµÑÐµÐ´Ð¸Ð½Ðµ Ð¿ÑÐ¾ÑÐ»Ð¾Ð³Ð¾ Ð²ÐµÐºÐ°. Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð´ÐµÑÑÐºÐ¸Ðµ Ð³Ð¾Ð´Ñ, Ð½Ð°ÑÐ°Ð»Ð¾ ÑÐ°Ð±Ð¾ÑÑ Ð¿Ð¸ÑÐ°ÑÐµÐ»Ñ Ð¸ Ð¶ÑÑÐ½Ð°Ð»Ð¸ÑÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸ÑÐ¼Ð¸ Ð¸ Ð²Ð¸Ð´Ð½ÑÐ¼Ð¸ Ð´ÐµÑÑÐµÐ»ÑÐ¼Ð¸, ÑÐ°ÐºÐ¸Ð¼Ð¸ ÐºÐ°Ðº ÐÐ°Ð¾ Ð¦Ð·ÐµÐ´ÑÐ½ Ð¸ Ð Ð¸ÑÐ°ÑÐ´ ÐÐ¾ÑÐ³Ðµ. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¾ÑÑÐ°Ð¶ÐµÐ½Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ ÑÑÐ¾ÑÐ¾Ð½ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐÐ³Ð½ÐµÑÑ Ð¡Ð¼ÐµÐ´Ð»Ð¸ - ÐºÐ°Ðº Ð¶ÑÑÐ½Ð°Ð»Ð¸ÑÑÐ°, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¾ÑÐ²ÐµÑÐ°ÐµÑ Ð²Ð¾ÐµÐ½Ð½ÑÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð² ÐÐ¸ÑÐ°Ðµ Ð´Ð»Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½ÑÑ ÑÑÐµÐ´ÑÑÐ² Ð¼Ð°ÑÑÐ¾Ð²Ð¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸, ÐºÐ°Ðº Ð¿Ð¸ÑÐ°ÑÐµÐ»Ñ, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð²ÐµÐ´ÐµÑ Ð·Ð°Ð¼ÐµÑÐºÐ¸ Ð¸ ÑÐ¾Ð·Ð´Ð°ÐµÑ Ð¿ÐµÑÐµÐ´ ÑÐ¸ÑÐ°ÑÐµÐ»ÐµÐ¼ Ð¾Ð±ÑÐ°Ð· ÐÐ¸ÑÐ°Ñ ÑÐ¾Ð³Ð¾ Ð²ÑÐµÐ¼ÐµÐ½Ð¸ Ð¸ Ð»ÑÐ´ÐµÐ¹, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐ°Ð¼ Ð¶Ð¸Ð»Ð¸ Ð¸ Ð±Ð¾ÑÐ¾Ð»Ð¸ÑÑ Ð·Ð° ÑÐ²Ð¾Ñ ÑÐ²Ð¾Ð±Ð¾Ð´Ñ, ÐºÐ°Ðº ÑÐ¿Ð¸Ð¾Ð½Ð°, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¿Ð¾Ð¼Ð¾Ð³Ð°Ð» Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸Ð·Ð¼Ð° Ð¸ ÑÐ²Ð»ÑÐ»ÑÑ ÑÐ²ÑÐ·ÑÑÑÐ¸Ð¼ Ð·Ð²ÐµÐ½Ð¾Ð¼ ÑÑÐ°Ð·Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¸Ñ ÑÑÑÐ°Ð½ - ÐÐ¸ÑÐ°Ñ, Ð¡Ð¨Ð, ÐÐµÑÐ¼Ð°Ð½Ð¸Ð¸, Ð¡Ð¡Ð¡Ð , ÐºÐ°Ðº Ð±Ð¾ÑÑÐ° Ð·Ð° Ð¿ÑÐ°Ð²Ð° Ð¶ÐµÐ½ÑÐ¸Ð½, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¾ÑÑÑÐ°Ð¸Ð²Ð°Ð» Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¸ Ð´ÐµÐ²ÑÑÐµÐº, Ð¿ÑÑÐµÑÐµÑÑÐ²ÑÑ Ð¿Ð¾ ÐÐ¸ÑÐ°Ñ Ð¸ ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¿Ð¾Ð¼Ð¾Ð³Ð°Ð» Ð¸Ð¼ ÑÐ°Ð·Ð½ÑÐ¼Ð¸ ÑÐ¿Ð¾ÑÐ¾Ð±Ð°Ð¼Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð¿ÑÐµÐ¸Ð¼ÑÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾ Ð¿Ð¾ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½ÑÐ¼ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ°Ð¼.
title: Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÑÑ ÐÐ­Ð¡ Ñ ÑÐµÐ°ÐºÑÐ¾ÑÐ°Ð¼Ð¸ ÐÐÐ­Ð -1000 Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 2Ñ 1000 ÐÐÑ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¨Ð°Ð±Ð°Ð½Ð¾Ð², ÐÐ°Ð½Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ñ
ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð°ÑÐ¾Ñ ÑÐ¾ÐºÐ°
ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð°ÑÐ¾Ñ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð¸Ñ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°ÑÑÐ¸ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¸. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ ÑÐµÑÐ½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°ÑÑÐµÑ Ð¸ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¹ Ð²ÑÐ±Ð¾Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÐ½Ð¾Ð¹ ÑÑÐµÐ¼Ñ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÑÐ½ Ð²ÑÐ±Ð¾Ñ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð Ð°ÑÑÑÐ¸ÑÐ°Ð½Ñ ÑÐ¾ÐºÐ¸ ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ, Ð¿Ð¾ ÐºÐ¾ÑÐ¾ÑÑÐ¼ Ð±ÑÐ»Ð¸ Ð²ÑÐ±ÑÐ°Ð½Ñ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÑ Ð¸ ÑÐ¾ÐºÐ¾Ð²ÐµÐ´ÑÑÐ¸Ðµ ÑÐ°ÑÑÐ¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð³Ð»Ð°Ð²Ð½Ð°Ñ ÑÑÐµÐ¼Ð° ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½ÑÐ¹ Ð¿Ð»Ð°Ð½ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð°.
Additional file 2 of Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies
Creators: name: Chen, Dong
name: Su, Xi
name: Zhu, Lizhang
name: Jia, Hao
name: Han, Bin
name: Chen, Haibo
name: Liang, Qingzhuang
name: Hu, Chenchen
name: Yang, Hao
name: Liu, Lisa
name: Li, Peng
name: Wei, Wei
name: Zhao, Yongsheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 2: Figure S2. Scatterplots of the correlation of 1-AUC values for targeted agents and chemotherapeutic drugs screened by two biological replicates. Each data point represents 1-AUC for a PTC organoid line treated by the indicated drug.
Gate-defined graphene double quantum dot and excited state spectroscopy
Creators: name: Liu, Xing Lan
name: Hug, Dorothee
name: Vandersypen, Lieven M. K.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A double quantum dot is formed in a graphene nanoribbon device using three top gates. These gates independently change the number of electrons on each dot and tune the inter-dot coupling. Transport through excited states is observed in the weakly coupled double dot regime. We extract from the measurements all relevant capacitances of the double dot system, as well as the quantized level spacing.
Additional file 1 of Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies
Creators: name: Chen, Dong
name: Su, Xi
name: Zhu, Lizhang
name: Jia, Hao
name: Han, Bin
name: Chen, Haibo
name: Liang, Qingzhuang
name: Hu, Chenchen
name: Yang, Hao
name: Liu, Lisa
name: Li, Peng
name: Wei, Wei
name: Zhao, Yongsheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 1: Figure S1. Gene copy number variations of paired PTC organoids and tumor tissues.
Outer Spiral Disks as Clues to Galaxy Formation and Evolution
Creators: name: Vlajić, Marija
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent studies of outer spiral disks have given rise to an abundance of new results. We discuss the observational and theoretical advances that have spurred the interest in disk outskirts, as well as where we currently stand in terms of our understanding of outer disk structure, ages and metallicities.
description: 5 pages, 2 figures. Accepted for publication in PASA. Invited review given at Galaxy Metabolism: Galaxy Evolution near and far, Sydney, 22-26 June 2009.
CARDIOVASCULAR COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING IN CONGENITAL HEART DISEASE
Creators: name: SECCHI, FRANCESCO
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: Cardiac magnetic resonance (CMR) is a non-invasive imaging modality highly reliable for studying cardiovascular morphology and function. Cardiac computed tomography (CCT) can give valuable anatomic information on CHD in children but implies radiation exposure, a relevant issue in children and newborns who are more radiosensitive than adult patients and have a longer lifetime to develop stochastic effects from radiation. We contributed to show the possibility to obtain an impressively low ionizing dose reduction in CHD patients also using standard 64-slice CT scanners. Conversely, CMR holds a pivotal role when functional and flow imaging is required. We showed the role of CMR in evaluating of patients percutaneously implanted with a pulmonary valve. Moreover, we proposed two new approaches for post-processing CMR images, regarding volume estimation of patients with a single ventricle, a rare CHD and a method for quantifying the paradoxical septal motion. CMR and CCT are two fundamental imaging techniques to evaluate patients with complex CHD. Both imaging modalities have limitations and advantages. CMR can evaluate heart function vessel flow but require a long acquisition time and in same patients a long sedation time. CCT has a very high spatial resolution and short acquisition time but implies ionizing radiation exposure. On the one side, we confirming the crucial role of CMR when function analysis is required but also showed the relevant possibilities of x-ray dose reduction in CCT, also using standard 64-slice scanners in the study of CHD patients.
Continuous approximation of breathers in one and two dimensional DNLS lattices
Creators: name: Bambusi, D.
name: Penati, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37K60

description: In this paper we construct and approximate breathers in the DNLS model starting from the continuous limit: such periodic solutions are obtained as perturbations of the ground state of the NLS model in $H^1(\RR^n)$, with $n=1,2$. In both the dimensions we recover the Sievers-Takeno (ST) and the Page (P) modes; furthermore, in $\RR^2$ also the two hybrid (H) modes are constructed. The proof is based on the interpolation of the lattice using the Finite Element Method (FEM).
Thinking Styles of Persons Deprived of Liberty at Davao City Jail
Creators: name: Irish P. Bandolos, Irish P. Bandolos
name: Rufa Mae I. Gordo, Rufa Mae I. Gordo
name: Caliar Klent Jan T. Calimpong, Caliar Klent Jan T. Calimpong
name: Enrique T. Umusig Jr., Enrique T. Umusig Jr.
Publisher: name: Zenodo
Year: 2024

description: This study aims to determine the extent of the thinking styles of persons deprived of liberty at theDavao City Jail. The researchers want to know the prevalent thinking styles of Persons Deprived of Liberty(PDL) at the Davao City Jail. Moreover, the study sought to determine the manifestation of criminal thinkingstyle in terms of mollification, cutoff, entitlement, power orientation, sentimentality, super optimism, cognitiveindolence, and discontinuity. The data of this study came from N-299 Persons Deprived of Liberty (PDL) at theDavao City Jail. They were collected using a random sampling technique to ensure they answered the questionshonestly. The Psychological Inventory of Criminal Thinking Styles (PICTS), a survey questionnaire from Walterand Kaufman (1995), was the research tool employed in the study. Through the use of a validated questionnaire,the mean and the standard deviation are determined. The study found that super optimism is prevalent amongall criminal thinking styles of Persons Deprived of Liberty (PDL) at the Davao City Jail. Further, the researcherrecommends that jail and correctional institutions ensure that their facilities have a psychologist who willprovide and oversee programs to lower recidivism rates and offer regular counseling to all prisoners
title: ÐÐ²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° Â«ÐÐ°Ð³Ð°Ð·Ð¸Ð½ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð¾Ð¹ ÑÐµÑ Ð½Ð¸ÐºÐ¸Â»
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾ÑÑÐ»ÐµÐ²Ð°, ÐÐ°ÑÐ°Ð»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ°
ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð±Ð°Ð·Ð°Ð¼Ð¸ Ð´Ð°Ð½Ð½ÑÑ
Ð±Ð°Ð·Ð° Ð´Ð°Ð½Ð½ÑÑ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ Ð²Ð¾Ð¿ÑÐ¾Ñ Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ð¸ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð² ÑÑÐµÑÐµ Ð¶Ð¸Ð»Ð¸ÑÐ½Ð¾-ÐºÐ¾Ð¼Ð¼ÑÐ½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾Ð·ÑÐ¹ÑÑÐ²Ð° (ÐÐÐ¥). ÐÐ° ÑÐµÐ³Ð¾Ð´Ð½ÑÑÐ½Ð¸Ð¹ Ð´ÐµÐ½Ñ Ð±Ð¾Ð»ÑÑÐ¸Ð½ÑÑÐ²Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² ÐÐÐ¥ Ð´ÐµÐ»Ð°ÐµÑÑÑ Ð²ÑÑÑÐ½ÑÑ. ÐÐ´Ð½Ð°ÐºÐ¾, ÑÐµÐºÑÑÐ¸Ð¹ ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¼Ð½Ð¾Ð³Ð¸Ðµ Ð¸Ð· Ð½Ð¸Ñ: ÑÐ°ÑÑÐµÑ Ð¸ Ð½Ð°ÑÐ¸ÑÐ»ÐµÐ½Ð¸Ðµ Ð¿Ð»Ð°ÑÐµÐ¶ÐµÐ¹ Ð½Ð°ÑÐµÐ»ÐµÐ½Ð¸ÐµÐ¼, Ð´Ð¸ÑÐ¿ÐµÑÑÐµÑÑÐºÐ°Ñ ÑÐ»ÑÐ¶Ð±Ð°, ÑÐ±Ð¾Ñ Ð¸ ÑÐ°Ð±Ð¾ÑÐ° Ñ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸ ÑÑÐµÑÑÐ¸ÐºÐ¾Ð² Ð²Ð¾Ð´Ñ, ÑÐµÐ¿Ð»Ð° Ð¸ Ð³Ð°Ð·Ð°, ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð¸Ð·Ð²ÐµÑÐµÐ½Ð¸Ð¹ Ð´Ð»Ñ Ð¶Ð¸Ð»ÑÑÐ¾Ð².
Investigating the effects of silencing the hippocampus in a probabilistic reversal learning task
Creators: name: Cooke, Matthew Bannerman
Publisher: name: University of British Columbia
Year: 2024

description: In the quest for rewards, which can range from food to other incentives, both animals and humans must navigate the inherent uncertainties of their environments. The ability to learn from and adapt to these uncertainties, modifying cognitive strategies for reward acquisition, is crucial. This adaptive process is compromised in various neurological and psychological disorders, including depression, obsessive-compulsive disorder (OCD), Parkinson’s disease, schizophrenia, among others. Traditionally, research has focused on the orbitofrontal cortex (OFC), striatum, and amygdala in forming probabilistic reward associations. Since the hippocampus is a brain region heavily involved in the formation and retrieval of memory, and probabilistic reversal learning is a learning task, we hypothesized that the hippocampus is involved. Emerging evidence, including prior research from our laboratory, suggests that hippocampal neurogenesis plays a role in modulating reward feedback sensitivity, hinting at a more nuanced involvement of the hippocampus in this process. Given the hippocampus' extensive connections with the prefrontal cortex (PFC), amygdala, and striatum, we hypothesized that it might be a critical contributor to probabilistic learning mechanisms. The hippocampus itself is not a monolithic structure. It is differentiated into dorsal and ventral domains, with the dorsal primarily implicated in cognitive tasks such as spatial navigation and the ventral in encoding emotional significance. While historically considered in a dichotomous framework, contemporary studies indicate that both hippocampal regions engage in various learning and memory functions. We employed both pharmacological and chemogenetic techniques to transiently inactivate the dorsal and ventral hippocampus. Pharmacological inactivation yielded observable effects in both regions. Chemogenetic inactivation of the dorsal hippocampus did not yield notable results. However, there were discernible and significant differences between the adeno- associated virus (AAV) treated and control groups. These findings may shed light on the differentiated, yet interrelated, roles of hippocampal regions in learning under uncertainty. Our research demonstrates that pharmacological inactivation of the dorsal and ventral hippocampus lead to changes in perseverative behaviours, deemed Win-Stay, as well as impulsivity. Furthermore, chemogenetic inactivation shows diffuse effects of DREADD treatment versus non-surgical controls. AAV surgery leads to a decrease in performance measures (total reversals) as well as perseverative behaviour.
title: Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÑÑ ÐÐ­Ð¡ Ñ 3 Ð±Ð»Ð¾ÐºÐ°Ð¼Ð¸ Ð ÐÐÐ-1000
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð¼ÐºÐ¸Ð½, ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÐ­Ð¡
ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÑÑ ÐÐ­Ð¡
Ð ÐÐÐ-1000
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GENE REGULATION BY MYC DURING B CELL ACTIVATION
Creators: name: TESI, ALESSANDRA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: c-Myc is a transcriptional regulator required for the cellular response to proliferative stimuli. The gene expression programs regulated by Myc in physiological settings remain to be clarified. Here, we provide a complete characterization of Myc-dependent regulatory events in primary mouse B cells following activation by bacterial lipopolysaccharide (LPS). Taking advantage of cells homozygous for a conditional knockout allele of c-myc, we induced deletion before LPS stimulation, followed by genome wide profiling of mRNA levels and Myc-DNA interactions. In contrast with previous studies, in which Myc was proposed to directly drive transcriptional amplification at all active loci (Nie et al. 2012, Lin et al. 2012), our study revealed that Myc is required for the up- and down-regulation of distinct subsets of genes early after stimulation, occurring prior to the global increase in RNA production. These gene expression programs where partially overlapping with those regulated by Myc upon oncogenic activation, a distinction made not only in B-cells, but also in fibroblasts (Sab� et al., 2014, Perna et al. 2012). Our data also show that Myc dependent regulation can occur at the level of RNA Polymerase II loading, as well as elongation. Altogether these data provide an extensive picture of Myc' s action in response to a mitogenic stimulus, highlighting the importance of Myc-target genes in the remodeling of cellular physiology and metabolism. Systematic work will be needed to unravel which, among all the Myc-regulated genes, are critical in mediating this chain of events.
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title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð¿Ð¸Ð½, ÐÐ¾Ð½ÑÑÐ°Ð½ÑÐ¸Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÑÐ°Ð»ÑÐ½ÑÐµ ÑÐ¾ÑÑÐ´Ñ
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title: Ð Ð°ÑÑÐµÑ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÑ Ð² Ð·Ð¾Ð½Ðµ Ð¼Ð¾ÑÑÐ¸ÐºÐ¾Ð² Ñ Ð¾Ð»Ð¾Ð´Ð° Ð²Ð±Ð»Ð¸Ð·Ð¸ Ð´Ð²ÐµÑÐ½ÑÑ Ð¿ÑÐ¾ÐµÐ¼Ð¾Ð² Ð±Ð¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑÐ°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÐ»Ð¸Ñ, ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
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