title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸Ð·Ð¸ÐºÐ¾-Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ñ Ð°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð¿Ð¾Ð»Ð¸ÑÐ°Ñ Ð°ÑÐ¸Ð´Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ° Ð²Ð°ÐºÑÐ¸Ð½Ñ Ð¿ÑÐ¾ÑÐ¸Ð² Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Investigation of the physicochemical characteristics of the polysaccharide component of the vaccine against Haemophilus influenzae
Creators: name: Ð¡ÑÑÑÑÐ½Ð¸Ð½, ÐÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð²Ð°ÐºÑÐ¸Ð½Ð° Ð¿ÑÐ¾ÑÐ¸Ð² Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¸ ÑÐ¸Ð¿Ð° Ð±
Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°Ñ Ð°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸
ÑÐ¼Ñ-ÑÐ¿ÐµÐºÑÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°Ñ Ð°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸
vaccine against hemophilian infection type b
molecular parameters of haemophilus influenzae capsule polysaccharide
nmr spectroscopy of haemophilus influenzae capsular polysaccharide

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ° Ð²Ð°ÐºÑÐ¸Ð½Ñ Ð¿ÑÐ¾ÑÐ¸Ð² Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸Â». ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð¼Ð°ÑÑÑ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ° Ð²Ð°ÐºÑÐ¸Ð½Ñ Ð¿ÑÐ¾ÑÐ¸Ð² H. Influenzae ÑÐ¸Ð¿Ð° b. Ð¡ÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð½ÐµÐºÐ¾ÑÐ¾ÑÑÑ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¿ÑÐ¾Ð´ÑÐºÑÐ¾Ð² Ð¾ÑÐ¸ÑÑÐºÐ¸ ÐºÑÐ»ÑÑÑÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸, ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐµÐ¹ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½ÑÐ¹ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´ H. Influenzae ÑÐ¸Ð¿Ð° b. ÐÐ¾Ð´Ð±Ð¾Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐµÑÑÐ° Ð½Ð° Ð¿Ð¾Ð´Ð»Ð¸Ð½Ð½Ð¾ÑÑÑ Ð¾ÑÐ¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° H. Influenzae ÑÐ¸Ð¿Ð° b. Ð Ð°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ ÐÐÐ Â«ÐÐ ÐÐ¢ÐÐÐÂ», Ð³Ð´Ðµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÑ Ð² ÑÐ°Ð¼ÐºÐ°Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð¼Ð°ÑÑÑ Ð¾ÑÐ¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÐÐ­ÐÐ¥, ÑÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÐ¾Ð² Ð½Ð° Ð¿Ð¾Ð´Ð»Ð¸Ð½Ð½Ð¾ÑÑÑ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð¸ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-Ð¼Ð°ÑÑÐ¾Ð²ÑÐµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸, ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ ÑÐ¸ÑÑÐ¾ÑÑ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸ Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð²Ð°ÑÐ¸Ð°Ð½Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð´Ð»Ð¸Ð½Ð½Ð¾ÑÑÐ¸ Ð¾ÑÐ¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ°Ð¿ÑÑÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð³ÐµÐ¼Ð¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð°Ð»Ð¾ÑÐºÐ¸.
description: Topic of the final qualification work: "Study of the physicochemical characteristics of the polysaccharide component of the vaccine against Haemophilus influenzae". This work is devoted to the study of the physicochemical properties of the capsular polysaccharide of Haemophilus influenzae. Tasks that were solved in the course of the study: 1. Determination of the molecular weight of the polysaccharide component of the H. influenzae type b vaccine. 2. Comparison of some physicochemical properties of the products of purification of the culture liquid containing capsular polysaccharide H. influenzae type b. 3. Selection of the optimal identity test for purified H. influenzae type b capsular polysaccharide. The work was carried out on Â«GRITVAKÂ», where the main experiments were carried out within the framework of the study: determination of the molecular weight of the purified capsular polysaccharide of Haemophilus influenzae using HPLC, a comparative analysis of immunochemical and physicochemical tests for the authenticity of the capsular polysaccharide. As a result, the molecular weight parameters of the Haemophilus influenzae capsular polysaccharide were established, an additional method for controlling the purity of the Haemophilus influenzae capsular polysaccharide was developed, and an additional option for determining the authenticity of the purified Haemophilus influenzae capsular polysaccharide was presented.