cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of Fibrinogen alpha C chain 5.9Â kDa fragment (FIC5.9), a biomarker for various pathological conditions, is produced in post-blood collection by fibrinolysis and coagulation factors
Creators: name: Kikuchi, Wataru
name: Nishimura, Motoi
name: Kuga, Takahisa
name: Sachio Tsuchida
name: Saito, Tatsuya
name: Satoh, Mamoru
name: Noda, Kenta
name: Kodera, Yoshio
name: Tomonaga, Takeshi
name: Nomura, Fumio
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: Additional file 1. Analysis of FIC5.9 releasing in coagulation factor-deficient plasma. (A) Mass spectrum of coagulation-depleted plasma reactivated using an APTT reagent. Synthesized FIC5.9 is indicated with a red line and SI-labeled FIC5.9 peptide is indicated with a blue line. (B) Quantification of FIC5.9 released by coagulation reactivation. The relative intensity of FIC5.9 was calculated by comparison with the intensity of the internal standard (SI-FIC5.9). The error bars represent the standard error of the mean (SEM) for three experiments.
Multivariate functional additive mixed models
Creators: name: Volkmann, Alexander
name: Stöcker, Almond
name: Scheipl, Fabian
name: Greven, Sonja
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: functional additive mixed model
subject: Multivariate functional principal components
subject: multivariate functional data
subject: snooker trajectories
subject: speech production
subject: 510 Mathematik

description: Multivariate functional data can be intrinsically multivariate like movement trajectories in 2D or complementary such as precipitation, temperature and wind speeds over time at a given weather station. We propose a multivariate functional additive mixed model (multiFAMM) and show its application to both data situations using examples from sports science (movement trajectories of snooker players) and phonetic science (acoustic signals and articulation of consonants). The approach includes linear and nonlinear covariate effects and models the dependency structure between the dimensions of the responses using multivariate functional principal component analysis. Multivariate functional random intercepts capture both the auto-correlation within a given function and cross-correlations between the multivariate functional dimensions. They also allow us to model between-function correlations as induced by, for example, repeated measurements or crossed study designs. Modelling the dependency structure between the dimensions can generate additional insight into the properties of the multivariate functional process, improves the estimation of random effects, and yields corrected confidence bands for covariate effects. Extensive simulation studies indicate that a multivariate modelling approach is more parsimonious than fitting independent univariate models to the data while maintaining or improving model fit.
Additional file 1: of Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56dim natural killer cells
Creators: name: Merkt, Wolfgang
name: Claus, Maren
name: Blank, Norbert
name: Hundemer, Michael
name: Cerwenka, Adelheid
name: Hanns-Martin Lorenz
name: Watzl, Carsten
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Antibody/staining panels. (DOCX 13 kb)
Additional file 1 of Progressive hemorrhagic injury and ischemia after severe traumatic brain injury according to hemoglobin transfusion thresholds: a post-hoc analysis of the transfusion requirements after head trauma trial
Creators: name: Gobatto, André L. N.
name: Solla, Davi
name: Brasil, Sérgio
name: Taccone, Fabio S.
name: Carlotti Jr, Carlos G.
name: Malbouisson, Luiz Marcelo S.
name: Paiva, Wellingson S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Mental Health

description: Additional file 1.
RESPONSABILIDAD CIVIL DE LOS MÉDICOS
Creators: name: Juan Carlos García Huayama
Publisher: name: Zenodo
Year: 2010

description: Sumario: 1.- Introducción. 2.- Naturaleza de la responsabilidad civil médica: ¿responsabilidad civil contractual o extracontractual?. 3.- responsabilidad objetiva o subjetiva. 4.- El artículo 1762 del Código Civil: limitación de la responsabilidad civil de los profesionales. 5.- La invalidez de los pactos anticipados de exoneración o limitación de responsabilidad.
The Audible Artefact: Promoting Cultural Exploration and Engagement with Audio Augmented Reality
Creators: name: Cliffe, Laurence
name: Mansell, James
name: Cormac, Joanne
name: Greenhalgh, Chris
name: Hazzard, Adrian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: This paper introduces two ongoing projects where audio augmented reality is implemented as a means of engaging museum and gallery visitors with audio archive material and associated objects, artworks and artefacts. It outlines some of the issues surrounding the presentation and engagement with sound based material within the context of the cultural institution, discusses some previous and related work on approaches to the cultural application of audio augmented reality, and describes the research approach and methodology currently engaged with in developing an increased understanding in this area. Additionally, it discusses the project within the context of related cultural and sound studies literature, presents some initial conclusions as a result of a practice-based approach, and outlines the next steps for the project.
description: 7 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:2412.08227
Additional file 4: Figure S3. of Diagnosis of a malayan filariasis case using a shotgun diagnostic metagenomics assay
Creators: name: Gao, Dian
name: Qiongfang Yu
name: Guangqiang Wang
name: Guitang Wang
name: Xiong, Fan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Typing of blast hits after analyzing subcutaneous tissue sample and details of the phylogenetic MEGAN output. (DOC 198 kb)
Eurysternus hamaticollis Balthasar 1939
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus hamaticollis

description: Eurysternus hamaticollis Balthasar, 1939
Fig. 48A
Eurysternus hamaticollis Balthasar, 1939e: 113 (original description). Type locality: French Guiana: Saint-Laurent-du-Maroni: Godebert. Name-bearing type: lectotype (SMF), designated by Jessop (1985), not examined.
Eurysternus hamaticollis – Blackwelder 1944: 197 (checklist). — Jessop 1985: 1101 (identification guide, designation of lectotype). — Martínez 1988b: 283 (comments). — Vulcano & Pereira 1967: 547 (key). — Amézquita et al. 1999: 119 (biodiversity). — Feer 2000: 32 (list for French Guiana); 2008: 62 (ecology, list); 2013: 767 (list for French Guiana). — Vaz-de-Mello 2000: 193 (checklist for Brazil). — Medina et al. 2001: 135 (checklist for Colombia). — Pulido-Herrera et al. 2003: 54 (list for Caquetá, Colombia). — Feer & Pincebourde 2005: 30 (list). — Hamel-Leigue et al. 2006: 16 (inventory for Bolivia). — Carpio et al. 2009: 469 (ecology). — Génier 2009: 240 (revision, distribution). — Camero 2010: 150, 166 (key, diagnosis). — Brûlé et al. 2011a: 193 (inventory). — Carvajal et al. 2011: 314–315 (cited for Ecuador). — Larsen 2011: 99 (list for Suriname); 2013: 97 (list for Suriname). — Vaz-de-Mello et al. 2011b: 88 (list). — Bezdek & Hajek 2012: 316 (catalogue of type). — Krajcik 2012: 107 (checklist). — Price & Feer 2012: 327 (list for French Guiana). — Solís & Kohlmann 2012: 7 (checklist for Costa Rica). — Ferrer-Paris et al. 2013: 109 (list). — Nunes et al. 2014: 408–410 (cited, list). — Silva et al. 2014: 348 (diversity). — Ratcliffe et al 2015: 195 (checklist for Peru). — Boilly 2018: 37 (list for French Guiana). — Chamorro et al. 2018: 95 (list for Ecuador); 2019: 144 (catalogue). — Hielkema & Hielkema 2019: 87 (catalogue for the Guianas).
Distribution
Costa Rica, Colombia, Venezuela, Guyana, French Guiana, Brazil, Peru, Ecuador, and Bolivia.
Subregions of Venezuela
Plains, Peneplain of the Casiquiare River–Upper Orinoco, System of hills and low piedmont mountains of the Guiana Shield, System of low mountains and hills Imataca-Cuyuní of Northeast Guyana Shield, and Guiana Shield.
Literature records
Martínez 1988b: 283 (Venezuela). — Génier 2009: 240 (Venezuela: Amazonas, Bolívar and Monagas). — Ferrer-Paris et al. 2013: 109 (Venezuela: Bolívar: Isla de Anacoco). — Boilly 2018: 37 (Venezuela). — Chamorro et al. 2019:144 (Venezuela).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on pages 122-124, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
Additional file 1 of Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
Creators: name: Vrillon, Agathe
name: Bousiges, Olivier
name: Götze, Karl
name: Demuynck, Catherine
name: Muller, Candice
name: Ravier, Alix
name: Schorr, Benoît
name: Philippi, Nathalie
name: Hourregue, Claire
name: Cognat, Emmanuel
name: Dumurgier, Julien
name: Lilamand, Matthieu
name: Cretin, Benjamin
name: Blanc, Frédéric
name: Paquet, Claire
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Hematology

description: Supplementary Material 1
Gynotyphlus Coiffait 1955
Creators: name: Assing, Volker
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Gynotyphlus

description: Gynotyphlus sp.
M a t e r i a l e x a m i n e d: Greece: Crete: 2♀♀, NE Lassithi Plateau, 35°13'N, 25°32'E, 850 m, dry ruderal stream valley with old Platanus, soil washing, 26.XII.2017, leg. Assing (cAss).
C o m m e n t: The above specimens are clearly not conspecific with Gynotyphlus perpusillus (DODERO, 1900), which is represented by eleven subspecies distributed in the Mediterranean from the Iberian Peninsula to Turkey (SCHÜLKE & SMETANA 2015). The material from Crete is distinguished from that seen from other regions by much larger size alone, additionally also by differently shaped sclerotized structures in the abdominal apex. Whether or not the species from Crete is parthenogenetic like most populations of G. perpusillus can be answered only when more material is available. In the meantime, the species remains unnamed.
description: Published as part of Assing, Volker, 2018, On the Staphylinidae of Crete III. The first records of endogean fauna (Coleoptera: Staphylinidae: Leptotyphlinae, Aleocharinae, pp. 7-15 in Linzer biologische Beiträge 50 (1) on page 13, DOI: 10.5281/zenodo.3985195
Eurysternus hypocrita Balthasar 1939
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus hypocrita

description: Eurysternus hypocrita Balthasar, 1939
Fig. 48B
Eurysternus hypocrita Balthasar 1939e: 114 (original description). Type locality: French Guiana: Cayenne. Name-bearing type: lectotype (SMF), designated by Jessop (1985), not examined.
Eurysternus hypocrita – Balthasar 1941: 340 (cited for Peru); 1951: 325 (cited for Peru). — Blackwelder 1944: 197 (checklist). — Halffter & Halffter 1976: 55 (comments). — Jessop 1985: 1101 (identification guide, cited as synonym of E. velutinus, designation of lectotype). — Génier 2009: 134, 287 (redescription, key). — Camero 2010: 149, 156 (key, diagnosis). — Brûlé et al. 2011a: 193 (inventory). — Carvajal et al. 2011: 314–315 (list, cited for Ecuador). — Larsen 2011: 99 (list for Suriname); 2013: 97 (list for Suriname). — Vaz-de-Mello et al. 2011b: 88 (list). — Bezděk & Hajek 2012: 316, 317 (catalogue of type specs). — Krajcik 2012: 107 (checklist). — Price & Feer 2012: 327 (list for French Guiana). — Ratcliffe 2013: 493 (list). — Bicknell et al. 2014: supp. (cited as E. hypocrite [sic]). — Silva et al. 2014: 348 (diversity). — Feer & Boissier 2015: 169 (list). — Ratcliffe et al. 2015: 195 (checklist for Peru). — Boilly 2018: 36–37 (key, comments). — Chamorro et al. 2018: 95 (cited for Ecuador); 2019: 144 (catalogue). — Hielkema & Hielkema 2019: 88 (catalogue for the Guianas).
Distribution
Colombia, Venezuela, Guyana, Suriname, French Guiana, Brazil, Ecuador, Peru, and Bolivia.
Subregions of Venezuela
Peneplain of the Casiquiare River–Upper Orinoco, System of hills and low piedmont mountains of the Guiana Shield, System of low mountains and hills Imataca-Cuyuní of Northeast Guyana Shield, and Guiana Shield.
Literature records
Génier 2009: 134 (Venezuela: Amazonas and Bolívar). — Chamorro et al. 2019: 145 (Venezuela). — Boilly 2018: 379 (Venezuela).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on page 124, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
MOESM1 of Word balloon catheter for Bartholin’s cyst and abscess as an office procedure: clinical time gained
Creators: name: Boama, Vincent
name: Horton, Joanne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Word balloon catheter insertion procedure technique and equipment list.
Rewriting Francité in the Cité nationale de l'histoire de l'immigration
Creators: name: Hall, Sara
Publisher: name: University of British Columbia
Year: 2009

description: In October 2007 France's new national immigration museum, the Cité nationale de l'histoire de l'immigration, opened its doors to the public. A project nearly twenty years in the making, the Cité represents the cooperation of authorities, experts, and numerous civil society actors. It rewrites the French national narrative to take into account France's diverse demographic reality, legitimizing immigration as a key foundation of the French state. Since the early 1980s, immigration has been a prominent feature of the French political landscape, with immigrants' struggle for rights and recognition accompanied by the rise of right-wing xenophobia and racism. In particular, it is populations originating in former French colonial possessions that have been central to the debates. Using the Cité as a case study, this thesis examines the evolution of French identity to an updated, multicultural model that strives to reconcile traditional French universalism with cultural and ethnic pluralism, encompassing the principle of 'unity in diversity.' The museum's permanent exhibit, Répères, highlights the important contribution to the French nation made by immigrants, but has been criticized for failing to adequately interrogate the colonial past, which intersects with immigration on many levels. Housed in the former Museum of the Colonies in the Palais de la Porte Dorée, the controversy surrounding the 'colonial lacuna' forced a deeper engagement with colonialism than was originally intended, particularly, through the museum's activities outside of the permanent exhibit. The museum must be understood as an active and dynamic institution, and space of negotiation between the state and civil society actors.
Additional file 1: Table S1. of Plasticity in growth of farmed and wild Atlantic salmon: is the increased growth rate of farmed salmon caused by evolutionary adaptations to the commercial diet?
Creators: name: Harvey, Alison
name: Solberg, Monica
name: Troianou, Eva
name: Carvalho, Gary
name: Taylor, Martin
name: Creer, Simon
name: Dyrhovden, Lise
name: Matre, Ivar
name: Glover, Kevin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Experimental crosses. Table S2. Approximate nutritional content of each diet. Table S3. PCR conditions for the microsatellite multiplex used to assign individuals back to family. Table S4. Multiple comparisons for overall growth for both groups and treatments using a Tukey adjustment for multiple comparisons. SE; standard error. Table S5. Model selection of the random effect of the generalized linear mixed effect model used to investigate survival. Table S6. Multiple comparisons for overall mortality for both groups and treatments using a Tukey adjustment for multiple comparisons. SE; standard error. (DOCX 25Â kb)
Eurysternus impressicollis Castelnau 1840
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus impressicollis

description: Eurysternus impressicollis Castelnau, 1840
Fig. 49A–B
Eurysternus impressicollis Castelnau, 1840: 93 (original description). Type locality: Colombia: Bolívar: Cartagena de Indias. Name-bearing type: neotype (MNHN), designated by Jessop (1985), not examined.
Eurysternus impressicollis – Harold 1869d: 1024 (catalogue, cited for Colombia). — Gillet 1911b: 25 (catalogue, cited for Colombia). — Luederwaldt 1911: 420 (biology). — Pessôa & Lane 1941: 409 (redescription). — Blackwelder 1944: 197 (list, cited for Colombia). — Halffter & Matthews 1966: 26 (comments). — Jessop 1985: 1100 (designation of neotype). — Escobar 2000: 208 (checklist for Colombia). — Noriega et al. 2007: 82 (list for Colombia). — Génier 2009: 169 (diagnosis, distribution). — Lozano 2010: 89 (list). — Ferrer-Paris et al. 2013: 109 (list). — Giraldo et al. 2018: 42 (guide). — Nieto et al. 2020: 136 (report).
Material examined
VENEZUELA ‒ Zulia • 2 specs; Rosario de Perijá; Jul. 2006; Curso NM2006 leg.; faeces, 13h; CEMT.
Distribution
Colombia and Venezuela (Génier 2009).
Subregions of Venezuela
Maracaibo Depression and Serrania of Perijá.
Literature records
Lozano 2010: 86 (Venezuela: Zulia). — Ferrer-Paris et al. 2013: 109 (Venezuela: Zulia: Rosario de Perijá).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on page 126, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
Melanophryniscus simplex CARAMASCHI & CRUZ 2002
Creators: name: Langone, José A.
name: Lavilla, Esteban O.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Bufonidae
Melanophryniscus
Melanophryniscus simplex

description: Melanophryniscus simplex CARAMASCHI & CRUZ, 2002
Atelopus tumifrons (no BOULENGER, 1905): MÜLLER, 1934:153.
Melanophryniscus tumifrons; BRAUN & BRAUN, 1980:124 (parte). DEIQUES et al., 2007:17.
Melanophryniscus simplex CARAMASCHI & CRUZ, 2002:311.
Localidad tipo: “ Brazil, Santa Catarina, Boca da Serra, near Bom Jardim do Sul, Municipality of São Joaquim (28º20'S, 49º38'W)”. Holotipo MZUSP 35599.
KWET et al., 2005:1. Colombo et al., 2007:304. GARCIA et al., 2007:89. KWET, 2007:72. MANEYRO et al., 2008:190. BENCKE, 2009:104. KWET et al., 2010:24. BIDAU et al., 2011:67. CARAMASCHI & CRUZ, 2011:8. GIASSON et al., 2011:642. HAAD et al., 2011:92. BALDO et al., 2012:61. GRANT et al., 2012:170. HADDAD et al., 2013:124. BALDO et al., 2014:421. SANTOS et al., 2014:53. SEGALLA et al., 2014:38. ZANK et al., 2014:e94625 [3]. BORNSCHEIN et al., 2015:e0142791 [32]. IOP et al., 2016:9. MACHADO et al., 2016:687. SEGALLA et al., 2016:36. PIE et al., 2017:196. ROSSA-FERES et al., 2017:265. CAPELETTI et al., 2019:19019. JECKEL et al., 2019:55. SEGALLA et al., 2019:70. VASCONCELOS et al., 2019:20. MOSER et al., 2021:440. LAVILLA et al., 2022:256.
Melanophryniscus pachyrhynus (no MIRANDA-RIBEIRO, 1920): VAZ-SILVA et al., 2008:37 (parte).
Comentarios: La fotografía que publicaran DEIQUES et al. (2007:17), atribuyéndola a M. tumifrons, es de un ejemplar de M. simplex.
BALDO et al. (2012a:56) indicaron que parte del material determinado como M. pachyrhynus por VAZ-SILVA et al. (2008:37) pertenece a M. simplex.
De acuerdo con el mapa de distribución presentado por ZANK et al. (2014:e94625 [4], fig. 1) y datos de MOSER et al. (2021:440), los especímenes procedentes de Canela y São Francisco de Paula, estado de Rio Grande do Sul, son asignados a M. simplex.
description: Published as part of Langone, José A. & Lavilla, Esteban O., 2024, UNA REVISIÓN HISTÓRICA DE LOS NOMBRES APLICADOS A LAS ESPECIES DEL GÉNERO MELANOPHRYNISCUS GALLARDO, 1961 (AMPHIBIA: ANURA: BUFONIDAE)., pp. 1-139 in Comunicaciones Zoológicas Museo Nacional De Historia Natural XIII on pages 37-38, DOI: 10.5281/zenodo.15271642
title: SPRACHSENSIBILISIERUNG IM FLÜCHTLINGSDISKURS ALS GEGENSTAND EINES PROBLEM- UND REFLEXIONSORIENTIERTEN DAF-/DAZ-UNTERRICHTS. Potenziale korpusgestützter Diskursanalysen der Wikipedia
Creators: name: Polajnar Lenarčič, Janja
name: Rebhan, Lena
Publisher: name: Universitäts- und Landesbibliothek Darmstadt
Year: 2024

description: Angesichts der wachsenden Relevanz digitaler Medien und dem Anspruch, im Unterricht auch digitalisierungsbezogene Kompetenzen zu stärken, erscheint der Einbezug internetbasierter Kommunikation in den korpusgestützten Unterricht sinnvoll und ergiebig. Eine digitale Ressource, die als multilingualer Diskursraum gerade für DaF-/DaZ-Lernende vielseitige Untersuchungsmöglichkeiten bietet, ist die Online-Enzyklopädie Wikipedia. An ihrem Beispiel zeigt dieser Beitrag didaktische Potenziale korpusgestützter Diskursanalysen auf. Es werden zwei didaktische Szenarien entworfen, durch die im Sinne eines problem- und reflexionsorientierten DaF-/DaZ-Unterrichts ein tiefergehendes Verstehen diskursrelevanter Personenbezeichnungen und Metaphern angeregt werden soll, welches ihre diskursspezifische Verwendung und insbesondere deren metasprachliche Aushandlung einschließt und somit einen sensiblen Umgang mit der Zielsprache ermöglicht.
Additional file 1: Figure S1. of Diagnosis of a malayan filariasis case using a shotgun diagnostic metagenomics assay
Creators: name: Gao, Dian
name: Qiongfang Yu
name: Guangqiang Wang
name: Guitang Wang
name: Xiong, Fan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Histopathological findings in the nodules of the left little finger. (DOC 2022 kb)
Additional file 2: of Coevolution of paired receptors in Xenopus carcinoembryonic antigen-related cell adhesion molecule families suggests appropriation as pathogen receptors
Creators: name: Zimmermann, Wolfgang
name: Kammerer, Robert
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Xenopus tropicalis ceacam N exon nucleotide sequences. Xenopus tropicalis ceacam N exon nucleotide sequences (Xenbase tropicalis 9.0 Chr07 unless otherwise indicated, e.g. Ensembl Xenopus JGI 4.2). EST, expressed sequence tag; N, N or Ig variable-like domain exon; P, pseudogene (stop codon in N exon). (DOCX 23Â kb)
Torrenticola haliki Pesic & Smit 2010
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Das, Mrinal Kumar
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Torrenticolidae
Torrenticola
Torrenticola haliki

description: Torrenticola haliki Pešić & Smit, 2010
(Fig. 4C)
Remarks. The single male specimen taken from the gut content of Botia dario agrees well with the original description of Torrenticola haliki, a species so far known only from Malaysia (Pešić and Smit 2010). This species was confused with Torrenticola semisuta (see: Wiles 1997, Pešić and Smit 2009a), from which it can easily be distinguished by the shape of palp with a short seta located on the nose-shaped anteroventral extension of P-2 (see Fig. 4C). New for India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas, Das, Mrinal Kumar & Bordoloi, Sabitry, 2013, A new species of water mite (Acari, Hydrachnidia) from Assam, India, found in the gut contents of the fish Botia dario (Botiidae), pp. 454-462 in Zootaxa 3746 (3) on page 458, DOI: 10.11646/zootaxa.3746.3.4, http://zenodo.org/record/216047
Additional file 2 of Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms
Creators: name: Calyn Moulton
name: House, Michael
name: Lye, Victoria
name: Tang, Colin
name: Krawiec, Michele
name: Joseph, David
name: Denham, James
name: Ebert, Martin
Publisher: name: Figshare
Year: 2015
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology

description: Online supplementary material providing metric results for the 21 patient subsample. (PDF 796 kb)
Additional file 2: of Diagnosis of a malayan filariasis case using a shotgun diagnostic metagenomics assay
Creators: name: Gao, Dian
name: Qiongfang Yu
name: Guangqiang Wang
name: Guitang Wang
name: Xiong, Fan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Methods. (DOC 31 kb)
Monatractides oxystomus K. Viets 1935
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Das, Mrinal Kumar
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Torrenticolidae
Monatractides
Monatractides oxystomus

description: Monatractides oxystomus (K. Viets, 1935)
Remarks. One male and one female specimens from the gut content of Botia dario agrees well with the original description of Monatractides oxystomus (K. Viets, 1935), a species widespread in streams of SE Asia. Monatractides oza (Cook, 1967), a species known from India (Maharashtra; Cook 1967, Pešić and Ranga Reddy 2009) differs in having slightly shorter and wider frontal platelets, but this character is known to be variable in this species (Lundblad 1969). A further difference (see Cook 1967: Fig. 244) is found in the absence of denticles at the distal margins of P-2 and P-3 (present in M. oxystomus, and in our specimens from Assam), but as stated by Pešić and Smit (2009b) the variability needs to be examined more to clarify the taxonomy. New for India.
Family Hygrobatidae
Hygrobates cf. sinensis Uchida & Imamura, 1951 (Fig. 4A–B)
Remarks. Hygrobates dadayi Cook, 1967 (India: Maharashtra, Tamil Nadu, Karnataka, Andhra Pradesh; Cook 1967, Pešić and Ranga Reddy 2009), similar in the relatively small acetabular plate in the female (Fig. 4A), was separated from H. sinensis (known from Japan and China) due to a shorter distoventral projection of P-2, and a different shape of males genital field. Only a single female was taken from the gut contents of the loach, so our record should be considered tentative until males are examined. New for India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas, Das, Mrinal Kumar & Bordoloi, Sabitry, 2013, A new species of water mite (Acari, Hydrachnidia) from Assam, India, found in the gut contents of the fish Botia dario (Botiidae), pp. 454-462 in Zootaxa 3746 (3) on pages 459-460, DOI: 10.11646/zootaxa.3746.3.4, http://zenodo.org/record/216047
Additional file 1 of Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms
Creators: name: Calyn Moulton
name: House, Michael
name: Lye, Victoria
name: Tang, Colin
name: Krawiec, Michele
name: Joseph, David
name: Denham, James
name: Ebert, Martin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: Computational Biology

description: Online supplementary material providing additional method details, patient images, metric values and statistical analysis. (PDF 0.46 kb)
Additional file 1 of Associations amongst dynamic knee stiffness during gait, quadriceps stiffness, and the incidence of knee osteoarthritis over 24 months: a cohort study with a mediation analysis
Creators: name: Li, Zongpan
name: Leung, Kam-Lun
name: Huang, Chen
name: Huang, Xiuping
name: Su, Shan
name: Chung, Raymond CK
name: Ding, Changhai
name: Fu, Siu-Ngor
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Ecology

description: Supplementary Material 1
Eurysternus sanbornei Gill 1990
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus sanbornei

description: Eurysternus sanbornei Gill, 1990
Fig. 51A
Eurysternus sanbornei Gill, 1990: 355 (original description). Type locality: Venezuela: Bolivar: 15 km E of Kavanayen. Name-bearing type: holotype (MIZA), not examined.
Eurysternus sanbornei – Génier 2009: 144 (revision). — Hielkema & Hielkema 2019: 89 (catalogue for the Guianas).
Distribution
Venezuela and Guyana (Génier 2009).
Subregions of Venezuela
System of low mountains and hills Imataca-Cuyuní of Northeast Guyana Shield, and Guiana Shield.
Literature records
Gill 1990: 355 (Venezuela: Bolívar). — Génier 2009: 144 (Venezuela: Bolívar).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on page 131, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
Austrotritia Sellnick 1959
Creators: name: Liu, Dong
name: Chen, Jun
name: Qiao, Gexia
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Oribotritiidae
Austrotritia

description: Austrotritia Sellnick, 1959 New record for China
Austrotritia Sellnick, 1959, p. 144; Märkel, 1964, p. 30; Walker, 1965, p. 30; Ramsay & Sheals, 1969, p. 104; Aoki, 1980, p. 63; Mahunka, 1990, p. 49; Niedbała, 2000, p. 122.
Indotritia (Macarotritia): Pérez-Íñigo, 1986, p. 188.
Type species: Austrotritia quadricarinata Sellnick, 1959
Diagnosis. The diagnosis for Austrotitia is mainly according to Niedbała (2000), except one modification: dorsal carina present or absent.
Distribution. China, Australia, Canary Islands, Finland, Hawaii, India, Indonesia, Japan, Malaysia, Maldives Islands, Nepal, Pacific Islands, Papua New Guinea, Philippines, Singapore, South Africa, Sri Lanka, Thailand, Vietnam.
description: Published as part of Liu, Dong, Chen, Jun & Qiao, Gexia, 2009, Review of Austrotritia (Acari: Oribatida: Oribotritiidae), with descriptions of two new species from China, pp. 54-64 in Zootaxa 2144 on page 55, DOI: 10.5281/zenodo.188619
A serial analysis of gene expression and an in vitro based approach to understanding mouse definitive endoderm development
Creators: name: Hassan, Ali Saleem
Publisher: name: University of British Columbia
Year: 2009

description: The definitive endoderm is one of the three germ layers of the embryo that are generated during gastrulation and gives rise to the lungs, liver, pancreas and the gut. Understanding the development of the definitive endoderm is crucial for future in vitro based approaches to regenerative medicine for diabetes or liver regeneration. However, progress in the understanding of definitive endoderm development has been limited by the lack of genetic markers specific to this tissue. To address this, our lab previously performed gene expression profiling of the definitive endoderm using Serial Analysis of Gene Expression. From this study, a number of genes expressed specifically in this tissue, including Nephrocan and Peptide YY, were uncovered. In an attempt to uncover novel genes expressed in the definitive endoderm, an extended study of this gene expression profiling was done, and two ESTs, Endy and NAPS, were further identified. Through whole mount in situ hybridization analysis of the early mouse embryo, expression of Endy and NAPS was seen in different cell populations of the developing definitive endoderm. In addition to the SAGE analysis, an ES cell differentiation system for definitive endoderm was set up, as a tool to study some of the early signaling pathways leading to the development of the definitive endoderm. Differentiation of mES cells using Activin induced expression of the novel definitive endoderm markers, Nepn and Pyy, in a temporal manner. Inhibition of TGFβ signaling during differentiation resulted in a significant down regulation of these genes. Furthermore, differentiation of mES cells mutant for TGFβ signaling factor Foxh1 revealed an expression pattern for Nepn and Pyy that was inconsistent with what is observed in vivo. Lastly, the ES cell differentiation system was also used to test expression of Endy and NAPS as little molecular information existed for these ESTs. Collectively, the characterization of these markers in vivo, and manipulations of the ES cell differentiation system to definitive endoderm will facilitate the creation of more accurate fate maps of the definitive endoderm, and address some of the questions regarding early lineage decisions during specification and patterning of this tissue.
Eurysternus superbus Genier 2009
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus superbus

description: Eurysternus superbus Génier, 2009
Fig. 51B–C
Eurysternus superbus Génier, 2009: 113 (original description). Type locality: Venezuela: Aragua: Parque Nacional Henri Pittier, Estación Biológica Rancho Grande, 1100 m a.s.l. Name-bearing type: holotype (CMNC), not examined.
Eurysternus superbus — Ferrer-Paris et al. 2013: 109 (list).
Material examined
VENEZUELA ‒ Aragua • 3 specs; Maracay, “La cumbre”; 1500 m; 14 Jun. 1993; O. Hillert leg.; CEMT • 1 spec.; same data as for preceding except for the date; 27 Jul. 1993; CEMT. ‒ Miranda • 3 specs; Altos de Pipe, Instituto Venezolano de Investigaciones Científicas (“ Campus IVIC ”); 10°23′51″ N, 66°58′15″ W; 1500 m a.s.l.; Jul. 2009; F.Z. Vaz-de-Mello leg.; CEMT. ‒ Yaracuy • 2 specs; Bolívar, Aroa; 10°22′10.56″ N, 68°50′16.94″ W; 1639 m a.s.l.; 21 Jul. 2009; M.Asmüssen, P. Colmenares and H. Martínez leg.; CEMT.
Distribution
Venezuela (endemic, Génier 2009).
Subregions of Venezuela
Andes mountains and Central Coast Mountain Range.
Literature records
Génier 2009: 113 (Venezuela: Aragua, Carabobo and Lara). — Ferrer-Paris et al. 2013: 109 (Venezuela: Miranda: Altos de Pipe).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on page 132, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
Additional file 1: Figure S1. of Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
Creators: name: Lau, Dawn
name: Hogseth, Marte
name: Phillips, Emma
name: O’Neill, Michael
name: Pooler, Amy
name: Noble, Wendy
name: Hanger, Diane
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: High intensity scans of western blots of control and Alzheimer’s disease (AD) post-mortem human brain tissue from Fig. 4 reveal weak detection of tau phosphorylated at (a) S202 (CP13) and (b) S396/S404 (PHF-1) in control brain tissue, whereas the signal in AD brain is overexposed when shown at this intensity. The molecular weight marker (50 kDa) is shown on the left. (PDF 2638 kb)
MOESM1 of The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3
Creators: name: Ambikai Gajan
name: Barnes, Valerie
name: Mengying Liu
name: Nirmalya Saha
name: Pile, Lori
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. RNAi in S2 cells leads to efficient knockdown of Sin3A and lid. Figure S2. Wing developmental defects observed upon reduction or overexpression of dKDM5/LID in male flies. Figure S3. Biological replicates of RNAseq data correlate significantly. Figure S4. Gene expression changes upon knockdown of Sin3A, lid or both in S2 cells as determined by RNAseq. Figure S5. QPCR validates RNAseq data. Figure S6. Flow cytometry analysis of S2 cells knocked down for Sin3A, lid or both under oxidative stress conditions. Figure S7. SIN3 directly binds the TSS of many gene targets.
Additional file 1 of Cost-benefit analysis of haemodialysis in patients with end-stage kidney disease in Abuja, Nigeria
Creators: name: Agada-Amade, Yakubu Adole
name: Ogbuabor, Daniel Chukwuemeka
name: Obikeze, Eric
name: Eboreime, Ejemai
name: Onwujekwe, Obinna Emmanuel
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Supplementary Material 1
TRANSIENCE_D5.2_The TRANSIENCE Project CDE Plan
Creators: name: Ikenze, Nwamaka
Publisher: name: Zenodo
Year: 2024
Subjects: Communication
dissemination
exploitation
promotional channels

description: This report, the Communication, Dissemination, and Exploitation (CDE) Plan, highlights the purpose of CDE activities in terms of the three distinct CDE pillars and outlines the key elements of the TRANSIENCE strategic CDE plan. The plan identifies target audiences for the project CDE activities, including policymakers, academics, industry actors, and the general public. The plan also describes the various CDE tools that will be utilised, ranging from the project visual identity, website, social media channels, and bi-monthly newsletters to events, publications, and synergies. Finally, the plan sets measurable targets (KPIs) to enable verification of CDE progress. The CDE plan will be revised and updated in months 24 and 42 to respond to challenges and reinforce successes observed during the implementation of this version of the plan.
Eurysternus truncus Genier 2009
Creators: name: Rosa, Cecilia Lozano De La
name: Cupello, Mario
name: Vaz-De-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eurysternus
Eurysternus truncus

description: Eurysternus truncus Génier, 2009
Fig. 52A
Eurysternus truncus Génier, 2009: 166 (original description). Type locality: Venezuela: Bolívar: 120 km S of El Dorado. Name-bearing type: holotype (CMNC), not examined.
Eurysternus truncus – Hielkema & Hielkema 2019: 89 (catalogue for the Guianas).
Distribution
Venezuela and Guyana (Génier 2009).
Subregions of Venezuela
System of hills and low piedmont mountains of the Guiana Shield, System of low mountains and hills Imataca-Cuyuní of Northeast Guyana Shield, and Guiana Shield.
Literature records
Génier 2009: 167 (Venezuela: Bolívar).
description: Published as part of Rosa, Cecilia Lozano De La, Cupello, Mario & Vaz-De-Mello, Fernando Z., 2024, The dung beetles of Venezuela (Coleoptera: Scarabaeidae: Scarabaeinae): catalogue and updated distribution, pp. 1-272 in European Journal of Taxonomy 959 (1) on page 132, DOI: 10.5852/ejt.2024.959.2677, http://zenodo.org/record/13945464
Additional file 1: Figure S1. of PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells
Creators: name: Byerly, Jessica
name: Halstead-Nussloch, Gwyneth
name: Ito, Koichi
name: Katsyv, Igor
name: Irie, Hanna
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: PRKCQ downregulation in MDA-231-LucD3H2LN cells results in G2-M arrest. Triple-negative MDA-231-LucD3H2LN cells were infected with PRKCQ shRNA lentiviral supernatant for 48 hours. Cells were fixed and stained with PI, and cell-cycle profile analysis was performed using flow cytometry. Results from four independent experiments were averaged. Figure S2 PRKCQ shRNA has no effect on growth of MDA231 cells that do not express detectable PKCθ protein. MDA231 cells expressing empty vector (EV) or PRKCQ shRNA (54) were grown in 3-D cultures for 7 days. (PDF 573 kb)
Testosterone-dependent vascular arachidonic acid metabolism in the regulation of insulin resistance and blood pressure
Creators: name: Vasudevan, Harish
Publisher: name: University of British Columbia
Year: 2009

description: Insulin resistance (IR) and elevated blood pressure (BP) are two key features of the metabolic syndrome, which play an important role in the development of secondary cardiovascular complications. Feeding rats a diet rich in sugars such as fructose induces IR followed by vascular abnormalities and elevation in BP. Insulin resistance impairs the fine balance between endothelial vasoconstrictors and vasorelaxants, which results in endothelial dysfunction (ED). Differences in sex hormones play an important role in the development of insulin resistance and blood pressure as testosterone is essential for the development of ED and the increase in BP. Testosterone regulates the cyclooxygenase and Cyp4A-catalyzed metabolites of arachidonic acid, which have been implicated in vascular homeostasis. However, their regulation by insulin is unclear. We hypothesized that In the presence of testosterone insulin resistance favors increased synthesis of vasoconstrictor metabolites of arachidonic acid, which contributes to the development of endothelial dysfunction and subsequent elevation of blood pressure. Intact and/or gonadectomized male Wistar rats were fed for 9-12 weeks with fructose following which changes in blood pressures and vascular reactivity were determined. Treatment with testosterone restored the elevated blood pressure in gonadectomized rats. In addition, fructose-feeding induced insulin resistance in intact rats, which was ameliorated by inhibiting the androgen receptor or 20-HETE synthesis. Insulin resistance increased Cyp4A1, 2/3 expression in the superior mesenteric artery (SMA), which was decreased by blocking testosterone function. Finally, the increase in BP and Cyp4A1, 2/3 were prevented by treating rats for 2 weeks with the Cyp4A inhibitor HET0016. The role of IR in arachidonate metabolism was evaluated by treatment with metformin (500 mg/kg) for 10 weeks. Prevention of insulin resistance prevented both endothelial dysfunction and the increase in BP. Further, inhibition of Cyp4A by DDMS improved endothelial relaxation in the SMA of only intact and untreated FFR but not the gonadectomized and metformin-treated groups. Similar effects were observed upon blocking COX with indomethacin. IR increased the participation of COX-2, which was testosterone-dependent in both aorta and SMA. In conclusion, in the presence of testosterone, IR induces vascular complications by altering arachidonic acid metabolism to increase vasoconstrictor levels.