cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Gro/TLE-NuRD Corepressor Complex Facilitates Tbx20-Dependent Transcriptional Repression
Creators: name: Greco, Todd M.
name: Kaltenbrun, Erin
name: Kennedy, Leslie M.
name: Li, Tuo
name: Cristea, Ileana M.
name: Slagle, Christopher E.
name: Conlon, Frank L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The cardiac transcription factor Tbx20 has a critical role in the proper morphogenetic development of the vertebrate heart, and its misregulation has been implicated in human congenital heart disease. Although it is established that Tbx20 exerts its function in the embryonic heart through positive and negative regulation of distinct gene programs, it is unclear how Tbx20 mediates proper transcriptional regulation of its target genes. Here, using a combinatorial proteomic and bioinformatic approach, we present the first characterization of Tbx20 transcriptional protein complexes. We have systematically investigated Tbx20 protein-protein interactions by immunoaffinity purification of tagged Tbx20 followed by proteomic analysis using GeLC-MS/MS, gene ontology classification, and functional network analysis. We demonstrate that Tbx20 is associated with a chromatin remodeling network composed of TLE/Groucho co-repressors, members of the Nucleosome Remodeling and Deacetylase (NuRD) complex, the chromatin remodeling ATPases RUVBL1/RUVBL2, and the T-box repressor Tbx18. We determined that the interaction with TLE co-repressors is mediated via an eh1 binding motif in Tbx20. Moreover, we demonstrated that ablation of this motif results in a failure to properly assemble the repression network and disrupts Tbx20 function in vivo. Importantly, we validated Tbx20-TLE interactions in the mouse embryonic heart, and identified developmental genes regulated by Tbx20:TLE binding, thereby confirming a primary role for a Tbx20-TLE repressor complex in embryonic heart development. Together, these studies suggest a model in which Tbx20 associates with a Gro/TLE-NuRD repressor complex to prevent inappropriate gene activation within the forming heart.
Data: Crosslinking Mass Spectrometry in Human Mitochondria: From Data Analysis Strategy to in situ Biological Findings
Creators: name: Ryl, Petra Sabine Jutta
Publisher: name: Technische Universität Berlin
Year: 2023
Subjects: subject: 543 Analytische Chemie
subject: 600 Technik, Technologie
subject: 572 Biochemie
subject: human mitochondria
subject: proteome-wide crosslinking mass spectrometry
subject: structural systems biology
subject: apoptosis-including factor AIFM1
subject: trifunctional enzyme complex ECHA ECHB
subject: humane Mitochondrien
subject: Proteom-weite Crosslinking Massensprektrometrie
subject: strukturelle Systembiologie
subject: trifunktionaler Enzymkomplex ECHA ECHB

description: These Research Data belong to the homonymous Doctoral Thesis "Crosslinking mass spectrometry in human mitochondria: From data analysis strategy to in situ biological findings" from Petra S. J. Ryl. For more details on this metadata, please refer to the appendix of the dissertation. Just briefly, Table S1: Presented data originate from DSS crosslinked mitochondria (as published in Ryl et al. 2020). Table S2: Presented data originate from DSSO crosslinked mitochondria after proteome fractionation into soluble and insoluble proteome. Table S3: List of identified residue pairs after 5% FDR calculation on link- and PPI-level. Those data originate from DSSO crosslinked mitochondria after proteome fractionation into soluble and insoluble proteome. Table S4: List of identified unique peptide pairs after 5% FDR calculation on link- and PPI-level. Those data originate from previously published data in E. coli (Lenz et al. 2021).
Alterations in rhythmic and non‐rhythmic resting‐state EEG activity and their link to cognition in older age
Creators: name: Cesnaite, Elena
name: Steinfath, Paul
name: Jamshidi Idaji, Mina
name: Stephani, Tilman
name: Kumral, Deniz
name: Haufe, Stefan
name: Sander, Christian
name: Hensch, Tilman
name: Hegerl, Ulrich
name: Riedel-Heller, Steffi
name: Röhr, Susanne
name: Schroeter, Matthias L.
name: Witte, A. Veronica
name: Villringer, Arno
name: Nikulin, Vadim V.
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: EEG
subject: aging
subject: periodic
subject: aperiodic
subject: cognition

description: While many structural and biochemical changes in the brain have previously been associated with older age, findings concerning functional properties of neuronal networks, as reflected in their electrophysiological signatures, remain rather controversial. These discrepancies might arise due to several reasons, including diverse factors determining general spectral slowing in the alpha frequency range as well as amplitude mixing between the rhythmic and non-rhythmic parameters. We used a large dataset (N = 1703, mean age 70) to comprehensively investigate age-related alterations in multiple EEG biomarkers taking into account rhythmic and non-rhythmic activity and their individual contributions to cognitive performance. While we found strong evidence for an individual alpha peak frequency (IAF) decline in older age, we did not observe a significant relationship between theta power and age while controlling for IAF. Not only did IAF decline with age, but it was also positively associated with interference resolution in a working memory task primarily in the right and left temporal lobes suggesting its functional role in information sampling. Critically, we did not detect a significant relationship between alpha power and age when controlling for the 1/f spectral slope, while the latter one showed age-related alterations. These findings thus suggest that the entanglement of IAF slowing and power in the theta frequency range, as well as 1/f slope and alpha power measures, might explain inconsistencies reported previously in the literature. Finally, despite the absence of age-related alterations, alpha power was negatively associated with the speed of processing in the right frontal lobe while 1/f slope showed no consistent relationship to cognitive performance. Our results thus demonstrate that multiple electrophysiological features, as well as their interplay, should be considered for the comprehensive assessment of association between age, neuronal activity, and cognitive performance.
Fitting In: The Roles of Social Acceptance and Discrimination in Shaping the Academic Motivations of Latino Youth in the U.S. Southeast
Creators: name: Perreira, Krista M.
name: Fuligni, Andrew
name: Potochnick, Stephanie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Using data on 459 Latino 9th graders from the LA-SIAA and the NC-SIAA studies, we evaluate the specific educational values and beliefs that motivate the academic achievement of Latino youth and contrast the school experiences of Latino youth in an emerging Latino community, North Carolina, with the school experiences of youth living in a traditional settlement community, Los Angeles. Despite their greater fears of discrimination, we find that Latino youth in North Carolina are more academically motivated than their peers in Los Angeles. This is partially because they are more likely to be immigrants. Being an immigrant, having a stronger sense of ethnic identification, and having a stronger sense of family obligation were each linked to a more positive view of school environments. Therefore, these factors each partially explained the immigrant advantage in academic motivation and helped to counter the harmful effects of discrimination on academic motivation.
Detection and Characterization of Hepatic Engraftment of Embryonic Stem Derived Cells by Fluorescent Stereomicroscopy
Creators: name: Hatada, Seigo
name: Caballero, Montserrat
name: Lightfoot Jr., Harry M.
name: Fair, Jeffrey H.
name: LaPaglia, Michael
name: Cairns, Bruce A.
name: Pleasant, Andrew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Embryonic Stem (ES) cells have been investigated as a potential replacement therapy for failed organs, such as the liver. However, detection of hepatic engraftment from candidate stem cells has been difficult due to low engraftment efficiency. Previous detection methods required that the graft be processed by molecular and/or immunohistochemical techniques, limiting further functional studies. This study evaluated the use of tri-dimensional (3-D) fluorescent stereomicroscopy for gross detection of ES cell derived hepatic engraftment.
The Will of the Many by James Islington on Audiobook New
Creators: name: Malone
Publisher: name: Zenodo
Year: 2024

description: The Will of the Many by James Islington

 

 

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The Will of the Many

James Islington

Page: 640

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ISBN: 9781982141172

Publisher: Gallery / Saga Press

 

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At the elite Catenan Academy, a young fugitive uncovers layered mysteries and world-changing secrets in this new fantasy series by internationally bestselling author of The Licanius Trilogy, James Islington. AUDI. VIDE. TACE. The Catenan Republic—the Hierarchy—may rule the world now, but they do not know everything. I tell them my name is Vis Telimus. I tell them I was orphaned after a tragic accident three years ago, and that good fortune alone has led to my acceptance into their most prestigious school. I tell them that once I graduate, I will gladly join the rest of civilised society in allowing my strength, my drive and my focus—what they call Will—to be leeched away and added to the power of those above me, as millions already do. As all must eventually do. I tell them that I belong, and they believe me. But the truth is that I have been sent to the Academy to find answers. To solve a murder. To search for an ancient weapon. To uncover secrets that may tear the Republic apart. And that I will never, ever cede my Will to the empire that executed my family. To survive, though, I will still have to rise through the Academy’s ranks. I will have to smile, and make friends, and pretend to be one of them and win. Because if I cannot, then those who want to control me, who know my real name, will no longer have any use for me. And if the Hierarchy finds out who I truly am, they will kill me.

Matthew 24:10-13 English Standard VersionThe Will of the Many - (The Hierarchy) by James IslingtonDirectory of Visa CategoriesThe Will of the Many (Hierarchy #1) (Hardcover)2 Nephi 29Proverbs 19:21 Many plans are in a man's heart, but theThe Will of the Many | Book by James Islington
Discovery of a Disk Gap Candidate at 20 AU in TW Hydrae
Creators: name: Akiyama, E.
name: Muto, T.
name: Kusakabe, N.
name: Kataoka, A.
name: Hashimoto, J.
name: Tsukagoshi, T.
name: Kwon, J.
name: Kudo, T.
name: Kandori, R.
name: Grady, C. A.
name: Takami, M.
name: Janson, M.
name: Kuzuhara, M.
name: Henning, T.
name: Sitko, M. L.
name: Mayama, J. C. Carson S.
name: Currie, T.
name: Thalmann, C.
name: Wisniewski, J.
name: Momose, M.
name: Ohashi, N.
name: Abe, L.
name: Brandner, W.
name: Brandt, T. D.
name: Egner, S.
name: Feldt, M.
name: Goto, M.
name: Guyon, O.
name: Hayano, Y.
name: Hayashi, M.
name: Hayashi, S.
name: Hodapp, K. W.
name: Ishi, M.
name: Iye, M.
name: Knapp, G. R.
name: Matsuo, T.
name: McElwain, M. W.
name: Miyama, S.
name: Morino, J. -I.
name: Moro-Martin, A.
name: Nishimura, T.
name: Pyo, T. -S.
name: Serabyn, G.
name: Suenaga, T.
name: Suto, H.
name: Suzuki, R.
name: Takahashi, Y. H.
name: Takato, N.
name: Terada, H.
name: Tomono, D.
name: Turner, E. L.
name: Watanabe, M.
name: Yamada, T.
name: Takami, H.
name: Usuda, T.
name: Tamura, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present a new Subaru/HiCIAO high-contrast H-band polarized intensity (PI) image of a nearby transitional disk associated with TW Hydrae. The scattered light from the disk was detected from 0.2" to 1.5" (11 - 81 AU) and the PI image shows a clear axisymmetric depression in polarized intensity at ~ 0.4" (~ 20 AU) from the central star, similar to the ~ 80 AU gap previously reported from HST images. Azimuthal polarized intensity profile also shows the disk beyond 0.2" is almost axisymmetric. We discuss two possible scenarios explaining the origin of the polarized intensity depression: 1) a gap structure may exist at ~ 20 AU from the central star because of shallow slope seen in the polarized intensity profile, and 2) grain growth may be occurring in the inner region of the disk. Multi-band observations at NIR and millimeter/sub-millimeter wavelengths play a complementary role in investigating dust opacity and may help reveal the origin of the gap more precisely.
description: 8 pages, 2 figures, ApJL accepted for publication
Real time phase imaging with an asymmetric transfer function metasurface
Creators: name: Wesemann, Lukas
name: Rickett, Jon
name: Davis, Timothy J.
name: Roberts, Ann
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The conversion of phase variations in an optical wavefield into intensity information is of fundamental importance for optical imaging technology including microscopy of biological cells. While conventional approaches to phase-imaging commonly rely on bulky optical components or computational post processing, meta-optical devices have recently demonstrated all-optical, ultracompact image processing methods. Here we describe a metasurface that exploits photonic spin-orbit coupling to create an asymmetric optical transfer function for real time phase-imaging. The effect of the asymmetry on transmission through the device is demonstrated experimentally with the generation of high contrast pseudo-3D intensity images of phase variations in an optical wavefield without the need for post-processing. This non-interferometric method has potential applications in biological live cell imaging and real-time wavefront sensing.
description: manuscript 11 pages, supplement 7 pages
The relationship between Trade Liberalization, Growth and Balance of Payments in Sub-Saharan Africa: Insights from Dynamic Panel Data Analysis
Creators: name: Epaphra, Manamba
name: Amin, Jennifer
name: Epaphra, Manamba
name: Amin, Jennifer
Publisher: name: Unknown
Year: 2022
Subjects: subject: Research Methods/ Statistical Methods
subject: liberalization
subject: growth
subject: balance of payments
subject: Sub-Sahara Africa

description: The general objective of this paper is to analyze the relationship between trade liberalization, growth, and the balance of payment in Sub-Saharan Africa. The paper covers a total of 37 sub-Saharan African countries for a period of 24 years, spanning from 1996 to 2019. The formal regression analysis makes use of generalized moment methods (GMM). We also allow control variables in sets of regressions, such as terms of trade, gross fixed capital formation, inflation, labor force, government debt, foreign direct investment, and real effect exchange rate. First, we examine the impact of trade liberalization, measured by trade-to-GDP ratio and tariffs, on economic growth (real GDP). Next, we analyze the impact of growth on trade balance and current account balance to examine whether higher economic growth due to trade liberalization leads to an effect on the balance of trade. Results in the growth model suggest that the trade-to-GDP ratio has a positive and significant effect on economic growth while tariffs exert no effect on growth. Empirical results show that in the balance of trade and current account balance models, economic growth, trade-to-GDP ratio, and tariffs exert a positive and significant impact on both the balance of trade and current account. The results imply that sub-Saharan governments and policymakers should pursue policies that will promote trade openness.
Intestinal crypts reproducibly expand in culture
Creators: name: Fuller, Megan K.
name: Henning, Susan J.
name: Shroyer, Noah F.
name: Sundaram, Nambirajan
name: Helmrath, Michael A.
name: Faulk, Denver M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In vitro growth techniques for intestinal crypts and single intestinal stem cells have been recently described, but several questions of translational importance remain unaddressed. The purpose of this study was to: first, evaluate if intestinal crypts reproducibly expand in vitro; second, determine the impact of age and region of intestine on crypt growth in vitro; and third, determine the effects of cryopreservation on crypt growth in vitro.
Machine learning glass caging order parameters with an artificial nested neural network
Creators: name: Zhang, Kaihua
name: Li, Xinyang
name: Jin, Yuliang
name: Jiang, Ying
Publisher: name: arXiv
Year: 2021
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Around a glass transition, the dynamics of a supercooled liquid dramatically slow down, exhibited by caging of particles, while the structural changes remain subtle. In alternative to recent machine learning studies searching for structural predictors of glassy dynamics, here we propose to learn directly particle caging features defined purely according to dynamics. We focus on three transitions in a simulated hard sphere glass model, the melting of ultra-stable glasses, the Gardner transition and the liquid to ordinary glass transition. Implementing the machine learning algorithm based on a two-level nested neural network, we attain not only proper caging order parameters for all three transitions, but also a phase classification for input samples. A finite-size scaling analysis of the phase classification results identifies the order of melting (first) and Gardner (second) transitions. A false positive is avoided, as the liquid to glass transition is indicated as a crossover, rather than a phase transition with a well-defined transition point. This study paves the way to a generic approach for learning dynamical features in glassy systems, with a minimum requirement of system-specific knowledge.
description: 19 pages, 21 figures
Graphene Spintronics
Creators: name: Han, Wei
name: Kawakami, Roland K.
name: Gmitra, Martin
name: Fabian, Jaroslav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The isolation of graphene has triggered an avalanche of studies into the spin-dependent physical properties of this material, as well as graphene-based spintronic devices. Here we review the experimental and theoretical state-of-art concerning spin injection and transport, defect-induced magnetic moments, spin-orbit coupling and spin relaxation in graphene. Future research in graphene spintronics will need to address the development of applications such as spin transistors and spin logic devices, as well as exotic physical properties including topological states and proximity-induced phenomena in graphene and other 2D materials.
description: 47 Pages, 6 figures
Aesthetics as a space of difference: The implicit sociology in Tanizaki Jun’ichirō’s A Golden Death
Creators: name: Zanotti, Pierantonio
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: Tanizaki Jun’ichirō’s short story Konjiki no shi (‘A golden death,’ 1914) tells the weird tale of a friendship between two young aspiring artists in early twentieth-century Japan. Watashi, the narrator, is a diligent student, has conventional ideas and becomes a conventional writer, while his friend Okamura, who is extremely wealthy and free to pursue his wildest ideas, develops to the most bizarre consequences his own original aesthetics based on the senses and the beauty of the human body. This story can be read by adopting a perspective that brings out its implicit sociology. Konjiki no shi describes the social trajectories of the two protagonists by tapping into Tanizaki’s “sense of the social.” By resorting to some socio-critical tools and to Pierre Bourdieu’s sociological theory, I will investigate how this story constructs and narrates the relationship between the two main characters and its evolution. Secondly, I will show how aesthetics, as understood as a set of historically situated practices and discourses dispersed in the story, constitutes a significant aspect of the differential characterization of the two protagonists and an important element to interpret their conducts. Tanizaki succeeds in summoning before the readers’ eyes the intersection of two social and aesthetic trajectories that do not appear to be governed by chance or the whim of invention, but respond to his awareness of their social matrices and evolutions, their stakes and costs.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Direct Detection of Structurally Resolved Dynamics in a Multiconformation Receptor−Ligand Complex
Creators: name: Wang, Xiang Simon
name: Tang, Hao
name: Tripathy, Ashutosh
name: Miller, Keith R.
name: Gromova, Anna V.
name: Singleton, Scott F.
name: Lee, Andrew L.
name: Carroll, Mary J.
name: Collins, Edward J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Structure-based drug design relies on static protein structures despite significant evidence for the need to include protein dynamics as a serious consideration. In practice, dynamic motions are neglected because they are not understood well enough to model – a situation resulting from a lack of explicit experimental examples of dynamic receptor-ligand complexes. Here, we report high-resolution details of pronounced ~1 ms timescale motions of a receptor-small molecule complex using a combination of NMR and X-ray crystallography. Large conformational dynamics in Escherichia coli dihydrofolate reductase are driven by internal switching motions of the drug-like, nanomolar-affinity inhibitor. Carr-Purcell-Meiboom-Gill relaxation dispersion experiments and NOEs revealed the crystal structure to contain critical elements of the high energy protein-ligand conformation. The availability of accurate, structurally resolved dynamics in a protein-ligand complex should serve as a valuable benchmark for modeling dynamics in other receptor-ligand complexes and prediction of binding affinities.
Hariśaṅkar Parsāī’s Ham ek umr se vāqif haiṁ: A memoir of the sufferings of an Indian literary satirist
Creators: name: Mangraviti, Fabio
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: The present work is an attempt at investigating Ham ek umr se vāqif haiṁ (‘I have known for a lifetime,’ 1989) a memoir by Hariśaṅkar Parsāī (1924-1995), commonly deemed as the most outstanding postcolonial Hindī literary satirist (vyaṅgyakār). The study aims at exploring the narrative strategies as well as the socio-cultural and ideological ends pursued by Parsāī in crafting this work. More precisely, much attention is given to the philosophical views of the writer, who consciously decided to avoid the autobiographical form in his writings. Indeed, he deemed the autobiography (ātmakathā) as a genre devoid of any social commitment. On the contrary, he considered memoirs as texts more suitable for conveying ideas on socio-cultural and political issues. Apart from this, considerable emphasis will be placed on the narratives Parsāī developed in this memoir in order to legitimize the socio-cultural function of the satirists, who are authors somehow marginalized by Hindī literary criticism. In order to focus on this issue, the study will engage with the analysis of Parsāī’s aesthetic relationship with the representatives of Nayī Kahānī, the major Hindī literary movement of the 1950s and 1960s.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
A Comprehensive Evaluation of Android ICC Resolution Techniques
Creators: name: Yan, Jiwei
name: Zhang, Shixin
name: Liu, Yepang
name: Deng, Xi
name: Yan, Jun
name: Zhang, Jian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Inter-component communication (ICC) is a widely used mechanism in mobile apps, which enables message-based control flow transferring and data passing between Android components. Effective ICC resolution requires precisely identifying entry points, analyzing data values of ICC fields, modeling related framework APIs, etc. Due to various control-flow- and data-flow-related characteristics involved and the lack of oracles for real-world apps, the comprehensive evaluation of ICC resolution techniques is challenging. To fill this gap, we collect multiple-type benchmark suites with 4,104 apps, covering hand-made apps, open-source, and commercial ones. Considering their differences, various evaluation metrics, e.g., number count, graph structure, and reliable oracle based metrics, are adopted on-demand. As the oracle for real-world apps is unavailable, we design a dynamic analysis approach to extract the real ICC links triggered during GUI exploration. By auditing the code implementations, we carefully check the extracted ICCs and confirm 1,680 ones to form a reliable oracle set, in which each ICC is labeled with 25 code characteristic tags. The evaluation performed on six state-of-the-art ICC resolution tools shows that 1) the completeness of static ICC resolution results on real-world apps is not satisfactory, as up to 38%-85% ICCs are missed by tools; 2) many wrongly reported ICCs are sent from or received by only a few components and the graph structure information can help the identification; 3) the efficiency of fundamental tools, like ICC resolution ones, should be optimized in both engineering and research aspects. By investigating both the missed and wrongly reported ICCs, we discuss the strengths of different tools for users and summarize eight common FN/FP patterns in ICC resolution for tool developers.
The pragmatics of blessings in Gedeo (south Ethiopia)
Creators: name: Golle, Tesfatsion Petros
name: Orkaydo, Ongaye Oda
name: Zekareas, Yetebarek Hizekeal
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: The Gedeo, a Cushitic-speaking group in southern Ethiopia, have a long tradition of blessing expressions ingrained in their native cosmology. The pragmatics of the Gedeo people's blessing utterances are examined in this article. Pertinent information was gathered from knowledgeable senior community members through interviews, and focus group discussions conducted between November 2020 and December 2021. The technique of gathering data also included non-participant observations. We have thematically analysed the data based on the situations in which the blessings are expressed and used to convey the intended meanings in the specific contexts, The expressive functions of blessings in Gedeo vary from context to context as would be expected, but, interestingly, they frequently revolve around praising Mageno ‘the Creator,’ shielding fellow community members from harm, boosting the land's productivity, safeguarding the environment, and upholding the general well-being of the community. We conclude that, while blessings have diverse meanings depending on the context in which they are expressed, their overall purpose is to preserve communal harmony and order.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Elena Valdameri. Indian Liberalism between Nation and Empire. The Political Life of Gopal Krishna Gokhale. 2022
Creators: name: Griffo, Maurizio
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Medical Staff Organization in Nursing Homes: Scale Development and Validation
Creators: name: Mor, Vincent
name: Intrator, Orna
name: Lima, Julie
name: Karuza, Jurgis
name: Caprio, Thomas
name: Katz, Paul R.
name: Dauenhauer, Jason
name: Caprio, Anthony
name: Zinn, Jacqueline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: PURPOSE: To construct a multidimensional self-report scale to measure nursing home (NH) medical staff organization (NHMSO) dimensions and then pilot the scale using a national survey of medical directors to provide data on its psychometric properties.

DESIGN AND METHODS: Instrument development process consisting of the proceedings from the Nursing Home Physician Workforce Conference and focus groups followed by cognitive interviews, which culminated in a survey of a random sample of American Medical Directors Association (AMDA) affiliated medical directors. Analyses were conducted on surveys matched to Online Survey Certification and Reporting (OSCAR) data from freestanding nonpediatric nursing homes. A total of 202 surveys were available for analysis and comprised the final sample.

RESULTS: Dimensions were identified that measured the extent of medical staff organization in nursing homes and included staff composition, appointment process, commitment (physiciancohesion; leadership turnover/capability), departmentalization (physician supervision, autonomy and interdisciplinary involvement), documentation, and informal dynamics. The items developed to measure each dimension were reliable (Cronbach's alpha ranged from 0.81 to 0.65).Intercorrelations among the scale dimensions provided preliminary evidence of the construct validity of the scale.

IMPLICATIONS: This report, for the first time ever, defines and validates NH medical staff organization dimensions, a critical first step in determining the relationship between physician practice and the quality of care delivered in the NH.
Prospects for versatile phase manipulation in the TEM: beyond aberration correction
Creators: name: Guzzinati, Giulio
name: Clark, Laura
name: Béché, Armand
name: Juchtmans, Roeland
name: Van Boxem, Ruben
name: Mazilu, Michael
name: Verbeeck, Jo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In this paper we explore the desirability of a transmission electron microscope in which the phase of the electron wave can be freely controlled. We discuss different existing methods to manipulate the phase of the electron wave and their limitations. We show how with the help of current techniques the electron wave can already be crafted into specific classes of waves each having their own peculiar properties. Assuming a versatile phase modulation device is feasible, we explore possible benefits and methods that could come into existence borrowing from light optics where so-called spatial light modulators provide programmable phase plates for quite some time now. We demonstrate that a fully controllable phase plate building on Harald Rose's legacy in aberration correction and electron optics in general would open an exciting field of research and applications.
description: 9 pages, 4 figures, special Ultramicroscopy issue for PICO2015 conference
EL SEÑOR NAKANO Y LAS MUJERES ePub gratis
Creators: name: Gattis
Publisher: name: Zenodo
Year: 2024

description: EL SEÑOR NAKANO Y LAS MUJERES de HIROMI KAWAKAMI

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EL SEÑOR NAKANO Y LAS MUJERES

HIROMI KAWAKAMI

Número de páginas: 224

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788466345828

Editorial: DEBOLSILLO (PUNTO DE LECTURA)

Año de edición: 2018

 

 

 

 

 

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Overview

 

El señor Nakano y las mujereses una tierna y delicada exploración del misterio que se oculta en lo ordinario. Las líneas que dibuja conforman, a la postre, un mural en el que ningún hilo llega a su final sin entrecruzarse con otro.

Cuando Hitomi empieza a trabajar en la tienda de segunda mano («Esto no es un anticuario», remarca su propietario), entra en un mundo muy particular. Allí habitan el señor Nakano, un enigmático hombre con varias exmujeres; Masayo, su hermana, una artista que nunca se ha casado, y Takeo, el otro empleado del establecimiento, un chico joven, tímido pero encantador.

Cada día, clientes del vecindario entran y salen del mismo modo que los objetos, cada uno con su historia única, se compran y venden. Así, la historia entre Hitomi y Takeo se mezcla y confunde con muchas otras.

Reseñas:«Extraordinario poder alusivo de la escritura, legado de los grandes artistas de la narrativa japonesa moderna. Sin duda.»Robert Saladrigas,La Vanguardia

«Una capacidad descriptiva y de evocación visual, sutileza y una disección apasionante de las relaciones y la conducta humana.»Flavia Company,El País

«Un libro maravilloso sobre la felicidad.»Berner Zeitung
Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures
Creators: name: Foster, Cliffa
name: Wells, Shawn
name: Wilborn, Colin
name: Outlaw, Jordan
name: Urbina, Stacie
name: Hayward, Sara
name: Taylor, Lem
name: Smith, Abbie
name: Wildman, Rob
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Background Increasing metabolism is a primary focus of many commercially available dietary supplements marketed to support weight management. Caffeine (e.g. anhydrous and herbal) and green tea are key ingredients in such products, augmenting resting energy expenditure (REE) and improving reported mood states (alertness, fatigue, focus, etc.). The purpose of this study was to evaluate the effects of a thermogenic dietary supplement (DBX) on REE, respiratory exchange ratio (RER), reported measures of alertness, focus, energy, concentration, fatigue, and hunger, as well as the general safety of the product based on electrocardiogram (ECG) and hemodynamic responses in habitual caffeine consumers.MethodsSix male and six female subjects (mean ± SD; 22.50 ± 3.22 years; 76.94 ± 14.78 kg; 22.7 ± 9.5% body fat), physically active (≥12 months), and moderate habitual caffeine consumers (<200 mg/day) received either two capsules of DBX containing 340 mg of total caffeine plus green tea extract, yerba mate extract, carnitine tartrate and other active ingredients or a placebo (PLC) in a double-blinded, crossover design. Heart rate (HR), blood pressure (BP), REE, RER and perceived mood states were measured at baseline and then hourly for four hours after ingesting either treatment. Results Resting energy expenditure was significantly increased at all four time points and significant increases were determined for perceived alertness (p = 0.026) and focus (p = 0.05) at hour 1 and for energy at 1 and 2 hours after treatment for the DBX group (p = 0.008 and p = 0.017, respectively). Additionally, perceived fatigue was decreased at the hour 1 assessment (p = 0.010). No significant differences were seen between DBX and placebo for hunger, anxiety, HR, BP, ECG patterns or RER. Conclusions The results of this investigation support that the proprietary blend of this thermogenic aid is capable of increasing REE for four hours post-ingestion while supporting increased focus, alertness, and energy as well as decreasing fatigue without promoting anxiety or causing significant changes in HR, BP, or ECG measurements in habitual caffeine consumers.
Inflationary epoch in the presence of holographic dark energy
Creators: name: Delgado, Paola C. M.
name: Ganz, Alexander
name: Lin, Chunshan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We analyze the effects of the holographic dark energy model in a single field slow-roll inflation, taking into account both the holographic and the dark radiation components. In particular, we obtain the background evolution and compute the scalar and tensor power spectra. For the scalar sector we show that the power spectrum of the curvature perturbation encompasses the standard single field result and a correction proportional to $Ω_{\rm hde}/ε$, where $Ω_{\rm hde}$ is the fractional density of the holographic component and $ε$ is the first slow-roll parameter. This correction might be of order unity in the very beginning of the inflationary phase and decays rapidly. For the primordial gravitational waves we find the spectral index receives a correction from the graviton mass term, which decays in the first inflationary e-folds.
description: 15 pages, 6 figures. This is the Accepted Manuscript version of an article accepted for publication in Journal of Cosmology and Astroparticle Physics. Neither SISSA Medialab Srl nor IOP Publishing Ltd is responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at the DOI link below
Hans Lagerqvist. Four Essays on Semitic Grammar and Dialectology. Quatre Essais sur la grammaire et la dialectologie sémitiques. 2020
Creators: name: Mengozzi, Alessandro
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Read-and-Run Constrained Coding for Modern Flash Devices
Creators: name: Hareedy, Ahmed
name: Zheng, Simeng
name: Siegel, Paul
name: Calderbank, Robert
Publisher: name: arXiv
Year: 2021
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The pivotal storage density win achieved by solid-state devices over magnetic devices in 2015 is a result of multiple innovations in physics, architecture, and signal processing. One of the most important innovations in that regard is enabling the storage of more than one bit per cell in the Flash device, i.e., having more than two charge levels per cell. Constrained coding is used in Flash devices to increase reliability via mitigating inter-cell interference that stems from charge propagation among cells. Recently, capacity-achieving constrained codes were introduced to serve that purpose in modern Flash devices, which have more than two levels per cell. While these codes result in minimal redundancy via exploiting the underlying physics, they result in non-negligible complexity increase and access speed limitation since pages cannot be read separately. In this paper, we suggest new constrained coding schemes that have low-complexity and preserve the desirable high access speed in modern Flash devices. The idea is to eliminate error-prone patterns by coding data only on the left-most page while leaving data on all the remaining pages uncoded. Our coding schemes work for any number of levels per cell, offer systematic encoding and decoding, and are capacity-approaching. Since the proposed schemes enable the separation of pages, we refer to them as read-and-run (RR) constrained coding schemes as opposed to schemes adopting read-and-wait for other pages. We analyze the new RR coding schemes and discuss their impact on the probability of occurrence of different charge levels. We also demonstrate the performance improvement achieved via RR coding on a practical triple-level cell Flash device.
description: 7 pages (double column), 4 figures, submitted to the IEEE International Conference on Communications (ICC)
Factor V Leiden Mutation and Thromboembolism Risk in Women Receiving Adjuvant Tamoxifen for Breast Cancer
Creators: name: Garber, Judy E.
name: Orcutt, James
name: Kaplan, Ellen
name: Shahab, Nasir
name: Levine, Ellis
name: Winer, Eric
name: Archer, Laura
name: Shapiro, Charles L.
name: Dressler, Lynn
name: Kimmick, Gretchen
name: Scalzo, Anthony
name: Atkins, James N.
name: Tolaney, Sara M.
name: Berliner, Nancy
name: Halabi, Susan
name: Paskett, Electra M.
name: Edge, Stephen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Tamoxifen use has been associated with increased risk of thromboembolic events (TEs) in women with breast cancer and women at high risk for the disease. Factor V Leiden (FVL) is the most common inherited clotting factor mutation and also confers increased thrombosis risk. We investigated whether FVL was associated with TE risk in women with early-stage breast cancer who took adjuvant tamoxifen.
[PDF] LOBA NEGRA descargar gratis
Creators: name: Weaver
Publisher: name: Zenodo
Year: 2024

description: LOBA NEGRA de JUAN GOMEZ-JURADO

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LOBA NEGRA

JUAN GOMEZ-JURADO

Número de páginas: 552

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788466666497

Editorial: S.A. EDICIONES B

Año de edición: 2019

 

 

 

 

 

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Overview

 

Vuelve Antonia Scott en la esperada continuación de Reina roja.

SEGUIR VIVAAntonia Scott no tiene miedo a nada. Solo a sí misma.

NUNCA FUEPero hay alguien más peligroso que ella. Alguien que podría vencerla.

TAN DIFÍCILLa Loba negra está cada vez más cerca. Y Antonia, por primera vez, está asustada.
Quantum Observable Generalized Orthoalgebras
Creators: name: Lei, Qiang
name: Liu, Weihua
name: Liu, Zhe
name: Wu, Junde
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Let ${\cal S}(\mathcal{H})$ denote the set of all self-adjoint operators (not necessarily bounded) on a Hilbert space $\mathcal{H}$, which is the set of all physical quantities on a quantum system $\mathcal{H}$. We introduce a binary relation $\bot$ on ${\cal S}(\mathcal{H})$. We show that if $A\bot B$, then $A$ and $B$ are affiliated with some abelian von Neumann algebra. The relation $\bot$ induces a partial algebraic operation $\oplus$ on ${\cal S}(\mathcal{H})$. We prove that $({\cal S}({\mathcal{H}}), \bot, \oplus, 0)$ is a generalized orthoalgebra. This algebra is a generalization of the famous Birkhoff\,--\,von Neumann quantum logic model. It establishes a mathematical structure on all physical quantities on $\mathcal{H}$. In particular, we note that $({\cal S}({\mathcal{H}}), \bot, \oplus, 0)$ has a partial order $\preceq$, and prove that $A\preceq B$ if and only if $A$ has a value in $Δ$ implies that $B$ has a value in $Δ$ for every Borel set $Δ$ not containing $0$. Moreover, the existence of the infimum $A\wedge B$ and supremum $A\vee B$ for $A,B\in \mathcal{S}(\mathcal{H})$ (with respect to $\preceq$) is studied, and it is shown at the end that the position operator $Q$ and momentum operator $P$ in the Heisenberg commutation relation satisfy $Q\wedge P=0$.
Supp Tables from RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkworm Bombyx mori.
Creators: name: Gajula Gopinath
name: Kuchi Srikeerthana
name: Tomar, Archana
name: Srikakolapu M. Ch. Sekhar
name: Kallare P. Arunkumar
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics

description: This file contains all the supplementary tables of the Manuscript.
Roles of Arrest-Defective Protein 1225 and Hypoxia-Inducible Factor 1α in Tumor Growth and Metastasis
Creators: name: Park, Jong Gil
name: Yim, Sun Hee
name: Yoo, Ji Young
name: Lee, Mi Ni
name: Kim, Hwan Mook
name: Lee, Seung Taek
name: Kim, Bora
name: Oh, Goo Taeg
name: Seo, Ji Hae
name: Kim, Kyu Won
name: Park, Ji Hyeon
name: Kim, Jeong Hun
name: Kim, Se Hee
name: Lee, Shi Nai
name: Jung, Bo Kyung
name: Ryeom, Sandra
name: Choi, Jae Hoon
name: Lee, Mi Ran
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Background Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). Murine arrest-defective protein 1A (mARD1A225) acetylates HIF-1α, triggering its degradation, and thus may play a role in decreased expression of VEGFA. Methods We generated ApcMin/+/mARD1A225 transgenic mice and quantified growth of intestinal polyps. Human gastric MKN74 and murine melanoma B16F10 cells overexpressing mARD1A225 were injected into mice, and tumor growth and metastasis were measured. VEGFA expression and microvessel density in tumors were assessed using immunohistochemistry. To evaluate the role of mARD1A225 acetylation of Lys532 in HIF-1α, we injected B16F10-mARD1A225 cell lines stably expressing mutant HIF-1α/K532R into mice and measured metastasis. All statistical tests were two-sided, and P values less than .05 were considered statistically significant.ResultsApcMin/+/mARD1A225 transgenic mice (n = 25) had statistically significantly fewer intestinal polyps than ApcMin/+ mice (n = 21) (number of intestinal polyps per mouse: ApcMin/+ mice vs ApcMin/+/mARD1A225 transgenic mice, mean = 83.4 vs 38.0 polyps, difference = 45.4 polyps, 95% confidence interval [CI] = 41.8 to 48.6; P < .001). The growth and metastases of transplanted tumors were also statistically significantly reduced in mice injected with mARD1A225-overexpressing cells than in mice injected with control cells (P < .01). Moreover, overexpression of mARD1A225 decreased VEGFA expression and microvessel density in tumor xenografts (P < .04) and ApcMin/+ intestinal polyps (P = .001). Mutation of lysine 532 of HIF-1α in B16F10-mARD1A225 cells prevented HIF-1α degradation and inhibited the antimetastatic effect of mARD1A225 (P < .001).ConclusionmARD1A225 may be a novel upstream target that blocks VEGFA expression and tumor-related angiogenesis.
Operation of an archaeological lead PbWO$_4$ crystal to search for neutrinos from astrophysical sources with a Transition Edge Sensor
Creators: name: Iachellini, N. Ferreiro
name: Pattavina, L.
name: Abdelhameed, A. H.
name: Bento, A.
name: Canonica, L.
name: Danevich, F.
name: Dubovik, O. M.
name: Fuchs, D.
name: Garai, A.
name: Mancuso, M.
name: Petricca, F.
name: Tupitsyna, I. A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The experimental detection of the CE$ν$NS allows the investigation of neutrinos and neutrino sources with all-flavor sensitivity. Given its large content in neutrons and stability, Pb is a very appealing choice as target element. The presence of the radioisotope $^{210}$Pb (T$_{1/2}\sim$22 yrs) makes natural Pb unsuitable for low-background, low-energy event searches. This limitation can be overcome employing Pb of archaeological origin, where several half-lives of $^{210}$Pb have gone by. We present results of a cryogenic measurement of a 15g PbWO$_4$ crystal, grown with archaeological Pb (older than $\sim$2000 yrs) that achieved a sub-keV nuclear recoil detection threshold. A ton-scale experiment employing such material, with a detection threshold for nuclear recoils of just 1 keV would probe the entire Milky Way for SuperNovae, with equal sensitivity for all neutrino flavors, allowing the study of the core of such exceptional events.
description: ltd proceeding