cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modulation of Somatosensory Alpha Rhythm by Transcranial Alternating Current Stimulation at Mu-Frequency
Creators: name: Gundlach, Christopher
name: Mueller, Matthias M.
name: Nierhaus, Till
name: Villringer, Arno
name: Sehm, Bernhard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: transcranial alternating current stimulation
subject: tACS
subject: mu-alpha
subject: brain oscillations
subject: electroencephalogram
subject: EEG
subject: somatosensory cortex
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: Introduction: Transcranial alternating current stimulation (tACS) is emerging as an interventional tool to modulate different functions of the brain, potentially by interacting with intrinsic ongoing neuronal oscillations. Functionally different intrinsic alpha oscillations are found throughout the cortex. Yet it remains unclear whether tACS is capable of specifically modulating the somatosensory mu-rhythm in amplitude. Objectives: We used tACS to modulate mu-alpha oscillations in amplitude. When compared to sham stimulation we expected a modulation of mu-alpha oscillations but not visual alpha oscillations by tACS. Methods: Individual mu-alpha frequencies were determined in 25 participants. Subsequently, blocks of tACS with individual mu-alpha frequency and sham stimulation were applied over primary somatosensory cortex (SI). Electroencephalogram (EEG) was recorded before and after either stimulation or sham. Modulations of mu-alpha and, for control, visual alpha amplitudes were then compared between tACS and sham. Results: Somatosensory mu-alpha oscillations decreased in amplitude after tACS was applied at participants’ individual mu-alpha frequency. No changes in amplitude were observed for sham stimulation. Furthermore, visual alpha oscillations were not affected by tACS or sham, respectively. Conclusion: Our results demonstrate the capability of tACS to specifically modulate the targeted somatosensory mu-rhythm when the tACS frequency is tuned to the individual endogenous rhythm and applied over somatosensory areas. Our results are in contrast to previously reported amplitude increases of visual alpha oscillations induced by tACS applied over visual cortex. Our results may point to a specific interaction between our stimulation protocol and the functional architecture of the somatosensory system.
Structure and size distribution of benthic macroinvertebrate communities along a eutrophication gradient in streams of the Ottawa Valley.
Creators: name: McKee, Sheri-Lynn D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Ecology.

description: The taxonomic composition and size structure of benthic macroinvertebrate assemblages from twelve streams were studied in relation to differences in trophic conditions. Orthocladiinae (Diptera: Chironomidae) were numerically dominant at 11 of the 12 sites, however the Hydropsychidae (Trichoptera) attained the highest biomass. Principal component analysis revealed differences in the composition of assemblages among rural and urban sites. Rural sites had higher densities of sensitive taxa such as Ephemeroptera, Chironominae and Simuliidae, while urban sites had higher densities of tolerant taxa such as Oligochaeta. Site scores on the first principal component, explaining the most taxonomic variability between regions, were significantly related to the nutrient differences between the rural and urban streams. The mean annual spectrum for the entire assemblage followed a unimodal distribution peaking at the 8 $\mu$g (dry mass) size class. Polynomial regression models fitted to the abundance per size class for the entire assemblage revealed a weak positive relationship with total phosphorus (TP). Subsequent analyses on the mean size spectra of seven dominant taxa revealed that the Oligochaeta and Hydroptilidae have significantly higher densities in the urban sites, which contain high TP, while the Ephemeroptera and Chironominae have significantly lower densities in these sites. The three other dominant taxa, including the Hydropsychidae, Tanypodinae and Orthocladiinae showed less obvious differences in densities per size class between regions. These results demonstrate that although the size spectra of the entire community may not be greatly influenced by differences in stream eutrophication, the spectra of certain key taxa do show responses of a higher magnitude. This discrepancy in detecting responses suggests that the size distribution of entire benthic assemblages is resilient to differences in stream productivity, despite significant changes in the taxonomic composition.
Performance Assessment Framework for Heavy Multi-Combination Vehicles with Electric Traction System
Creators: name: Allwright, Joshua Thomas
Publisher: name: Swinburne
Year: 2024

description: This thesis expands vehicle electrification to a heavier class of vehicles, to address the emission reduction issues within the road freight industry. While the passenger car industry is shifting towards electric vehicles, the road freight industry is still predominantly relying on fossil fuels to power its vehicles. This thesis plays a critical role as a paradigm shift in what vehicles can be electrified, while also reducing total emissions. Additionally, the field of vehicle modelling was extended, presenting new computationally efficient techniques to model vehicles.
In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses
Creators: name: Regus-Leidig, Hanna
name: Fuchs, Michaela
name: Löhner, Martina
name: Leist, Sarah R.
name: Leal-Ortiz, Sergio
name: Chiodo, Vince A.
name: Hauswirth, William W.
name: Garner, Craig C.
name: Brandstätter, Johann H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Piccolo is the largest known cytomatrix protein at active zones of chemical synapses. A growing number of studies on conventional chemical synapses assign Piccolo a role in the recruitment and integration of molecules relevant for both endo- and exocytosis of synaptic vesicles, the dynamic assembly of presynaptic F-actin, as well as the proteostasis of presynaptic proteins, yet a direct function in the structural organization of the active zone has not been uncovered in part due to the expression of multiple alternatively spliced isoforms. We recently identified Piccolino, a Piccolo splice variant specifically expressed in sensory ribbon synapses of the eye and ear. Here we down regulated Piccolino in vivo via an adeno-associated virus-based RNA interference approach and explored the impact on the presynaptic structure of mouse photoreceptor ribbon synapses. Detailed immunocytochemical light and electron microscopical analysis of Piccolino knockdown in photoreceptors revealed a hitherto undescribed photoreceptor ribbon synaptic phenotype with striking morphological changes of synaptic ribbon ultrastructure.
3868060.pdf
Creators: name: Midolo, Leonardo
name: Papon, Camille
name: Zhou, Xiaoyan
name: Thyrrestrup, Henri
name: Liu, Zhe
name: Stobbe, Soren
name: schott, rüdiger
name: Wieck, Andreas
name: Ludwig, Arne
name: Lodahl, Peter
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information
title: Yellow millet dream
title: for string quartet
titleType: Subtitle
Creators: name: Xu, Qing
Publisher: name: University of Iowa
Year: 2024
Subjects: Chinese culture
Contemporary Music
Daoism
Religious Music
String Quartet

description: "Yellow Millet Dream" is a classic fable in Chinese Taoist culture. Lü Dongbin, one of the Eight Immortals of Taoism, falls into a deep sleep while waiting for his yellow millet to simmer. In his dream, he experiences a range of life's highs and lows, from the pinnacle of officialdom to the depths of despair, only to awaken and realize it was all an illusion. While the yellow millet has yet to fully cook.The music begins with pizzicato, imitating the sporadic raindrops of a gloomy day. As Lü enters his dream, the rhythm transforms from simple to intricate, and the pitch shifts from serene clarity to complexity and ambiguity. The composition ends with an unresolved melodic line, symbolizing the philosophical thinking: Is our perceived reality genuine, or just a figment of our imagination? And if our current experience is indeed a dream, would we choose to awaken? Would you feel lost if the dream ended?
Learning recursive definitions in prolog.
Creators: name: Rios, Riverson.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Artificial Intelligence.

description: Inductive Logic Programming (ILP) is one of the new and fast growing sub-fields of artificial intelligence. Given a specification language, the goal is to induce a logic program from examples of how the program should work (and also of how it should not work). One main difficulty of ILP lies in learning recursively defined predicates. Today's systems strongly rely on a set of supporting predicates known as the background knowledge that helps define the recursive clause. The dependence on background knowledge has its drawbacks in that it is assumed that the user knows in advance what sort of predicates are required by the target definition. Predicate invention, a research topic that has received a lot of attention lately, can remedy the situation by extending the specification language with new concepts, which appear neither in the examples nor in the background knowledge, and finding a definition for them. A serious concern is that no examples of the invented predicate are explicitly given but rather of the target predicate, so learning has to be done in the absence or scarcity of examples. This research is concerned with the problem of learning recursive definitions based on inverting clausal implication from a small data set. The aim is both to derive an autonomous learning method that can invent the recursive predicates it needs, and to implement it in an efficient manner. Experiments show that the system is capable of finding a correct definition of many relations by inventing the necessary predicates, but does not perform very well on random examples. A comparison between several similar systems that learn recursive definitions of a single predicate is shown. We also show the need for system-generated negative examples and discuss several pitfalls of predicate invention and the absence/scarcity of examples.
3868060.pdf
Creators: name: Midolo, Leonardo
name: Papon, Camille
name: Zhou, Xiaoyan
name: Thyrrestrup, Henri
name: Liu, Zhe
name: Stobbe, Soren
name: schott, rüdiger
name: Wieck, Andreas
name: Ludwig, Arne
name: Lodahl, Peter
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplementary information
A retrospective study on the survival of natural teeth adjacent to posterior Straumann implants
Creators: name: Martinez, Maria A.
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract

description: Objective: The purpose of this study was to determine the survival outcome of natural teeth adjacent to posterior Straumann tissue level and bone level implants. Methods: Data was retrospectively evaluated using Axium Electronic Health Records system (EHR) from 2008 to 2017. Inclusion criteria: single implants placed in posterior sites with adjacent natural teeth on both sides at the time of placement. Hawk IRB approvals #202003237 and #202105431 were obtained prior to initiating different parts of the study. The analysis focused on Straumann implants (tissue (TL) and bone level (BL)). A total of 189 patients and 216 individual implant sites were evaluated. Data collected were caries risk assessment, soft and hard tissue information, periodontal charting (when possible), and 4-bitewing radiographs were taken (when possible). By comparing the hard tissue information on Axium at the time of implant placement to the documented treatment completion overtime, it was determined whether the subjects had received any restorative treatment, endodontic work and/or teeth extractions to the adjacent teeth.
description: Results: 216 sites of interest and 162 individual patient charts met the inclusion criteria. An additional 139 subjects were invited to return for periodic oral evaluations, of these twenty-seven subjects returned for these exams, for a total 189 patients. Statistical analysis showed subjects with high and moderate caries risk were more likely to have restorative work on adjacent teeth (marginally significant). Patients with BL implants received dental treatment 0.46 times less often than those with BL implants. A p-value of 0.05 demonstrates there was a statistical significance between Straumann tissue level or bone level implants on the survival of adjacent natural teeth. Caries risk assessment via DMFT and ADA CRA tools had a statistical significance for dental treatment after implant placement for moderate and high-risk patients (p-value = 0.06 and 0.02 respectively).
description: Conclusion: Recommendation for caries risk assessment to be done as part of diagnostics and treatment planning when planning for dental implants. Patients should be thoroughly educated on oral hygiene and diet education as well as implant complications. The most common treatment modality was tooth extraction of an adjacent tooth and tooth extraction replaced by a dental implant.
Acoustic Signal Processing in Subject and Object in the Loop Configurations
Creators: name: Zhang, Lin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Engineering, Mechanical.

description: Acoustic signal processing is a discipline dealing with the information extracted from sound signals with applications in industry, entertainment areas etc. Two experimental configurations concerning real-time acoustic signal processing are developed for: voice manipulation and machine fault diagnosis, which share the same experimental equipment and signal processing software. First experimental study is based on the voice manipulation technique in a subject-in-the-loop configuration. A human voice was altered and fed back to the human subject in a signal manipulation process. The experimental setup validity was verified and real-time applications were achieved. Second experiment was conducted on a drive-motor-system to detect the fixture fault conditions due to loose bolts. An object-in-the-loop fault diagnosis system was developed using the acoustic signals acquired from loose/healthy conditions. The result presents that the loose versus healthy conditions can be identified in real-time. The numerical result illustrates the pattern of natural frequencies change under both conditions.
Edge Conditions for the Junction of Two Resistive Half-Planes with Different Surface Impedances
Creators: name: Braver, Igor M.
name: Fridberg, Pinchos Sh.
name: Garb, Khona L.
name: Yakover, Iosif M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: This work presents an analysis of the behavior of an electromagnetic field near the common edge of two resistive half-planes with different surface impedances. Contrary to the case of a single resistive half-plane, in the case of the impedance junction, both electric and magnetic fields' transverse components simultaneously contain a logarithmic singularity. It is shown that a surface current density has a finite jump that is proportional to the difference between the inverse impedances.
description: 4 pages, 1 figure
Characterization of the human RFX transcription factor family by regulatory and target gene analysis
Creators: name: Sugiaman-Trapman, Debora
name: Vitezic, Morana
name: Jouhilahti, Eeva-Mari
name: Mathelier, Anthony
name: Lauter, Gilbert
name: Misra, Sougat
name: Daub, Carsten O
name: Kere, Juha
name: Swoboda, Peter
Publisher: name: BioMed Central
Year: 2018

description: Background: Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal differentiation. Here, we provide a comprehensive analysis of all the eight human RFX genes (RFX1–8), their spatial and temporal expression profiles, potential upstream regulators and target genes. Results: We extracted all known human RFX1–8 gene expression profiles from the FANTOM5 database derived from transcription start site (TSS) activity as captured by Cap Analysis of Gene Expression (CAGE) technology. RFX genes are broadly (RFX1–3, RFX5, RFX7) and specifically (RFX4, RFX6) expressed in different cell types, with high expression in four organ systems: immune system, gastrointestinal tract, reproductive system and nervous system. Tissue type specific expression profiles link defined RFX family members with the target gene batteries they regulate. We experimentally confirmed novel TSS locations and characterized the previously undescribed RFX8 to be lowly expressed. RFX tissue and cell type specificity arises mainly from differences in TSS architecture. RFX transcript isoforms lacking a DNA binding domain (DBD) open up new possibilities for combinatorial target gene regulation. Our results favor a new grouping of the RFX family based on protein domain composition. We uncovered and experimentally confirmed the TFs SP2 and ESR1 as upstream regulators of specific RFX genes. Using TF binding profiles from the JASPAR database, we determined relevant patterns of X-box motif positioning with respect to gene TSS locations of human RFX target genes. Conclusions: The wealth of data we provide will serve as the basis for precisely determining the roles RFX TFs play in human development and disease.
Wir brauchen mehr Transparenz für einen fairen Wettbewerb
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2023

description: Die Redaktion des DC MAG sprach mit Marina Köhn, Wissenschaftliche Mitarbeiterin beim Umweltbundesamt (UBA), über die Zukunft des Blauen Engels. Sie plädiert für mehr Transparenz auf dem Markt und einen fairen Wettbewerb. Dr. Dieter Thiel, Senior Consultant bei der Data Center Group (DCG), der seit vielen Jahren als Experte an den Themen Energieeffizienz und Nachhaltigkeit arbeitet, ist Mitglied im Expertenkreis "Blauer Engel" des UBA. Im Gespräch mit DC MAG diskutieren die beiden aktuelle Entwicklungen und den Rechenzentrumsmarkt der Zukunft. Quelle: https://datacenter-group.com/
Performance of a low-cost particulate matter sensor in a swine barn
Creators: name: Rowland, Holly
Publisher: name: University of Iowa
Year: 2024
Subjects: Industrial Hygiene

description: Low-cost particulate matter (PM) sensors have gained popularity due to their ability to measure PM concentrations. PM concentrations measured with one affordable PM sensor, the Sensirion SPS30, compare favorably to reference instruments over short deployments in urban, environmental, and laboratory settings. PM in swine barns is dominated by large particles, including particles termed inhalable by OSHA and PM smaller than 10 µm (PM10) by EPA. This study evaluated the precision, accuracy, and bias of the SPS30 sensor in an active swine barn over one month. Four SPS30 sensors were collocated to assess their precision. Reference instruments were placed at this same location once a week for two hours to assess accuracy and bias. The precision of the SPS30 sensors across the study period was widely dispersed from week to week with coefficient of variations ranging from 5-33%. The sensors were not highly correlated with the reference instrument for the entirety of the study; r values ranged from 0.32-0.93 among each SPS30 sensor over each reference sampling event. The concentrations measured with the SPS30s were consistently 5-10 times lower than the reference instrument over the entire sampling period. The poor performance here may be attributed to the large size of the particulate matter in the swine barn compared to other environments where they have been tested. Overall, the sensors provided heavily biased but reasonably precise measurements throughout sampling, suggesting that they may be an inexpensive way to indicate when conditions are extremely dirty or clean in a swine barn. Future work should investigate their long-term performance in occupational environments that have PM of different compositions and smaller sizes than in the swine barn.
Processes for developing affordable and sustainable medium-density housing models for greyfield precincts
Creators: name: Murray, Shane
name: Bertram, Nigel
name: Khor, Lee Anne
name: Rowe, Deborah
name: Meyer, Byron
name: Murphy, Catherine
name: Newton, Peter
name: Glackin, Stephen
name: Alves, Tom
name: McGauran, Rob
name: Australian Housing
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3304
subject: Urban and regional planning

description: Abstract not available.
A model of a partially flooded anode-backing layer (ABL) in a direct methanol fuel cell (DMFC)
Creators: name: Saleh, Jehad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Chemical.
subject: Energy.

description: Direct methanol fuel cells (DMFCs) generate electrical energy from an electro-chemical reaction between methanol and oxygen in the presence of a platinum containing electro-catalyst. They normally have the following components: (a) the anode gas channel, (b) the anode backing layer (that distributes liquid methanol and water from the anode gas channel to the anode catalyst layer), (c) the anode catalyst layer (that performs the reaction, CH 3OH + 2H2O = CO2 + 6H+ + 6 e -), (d) the electrolyte layer (that transports H+ from the anode catalyst layer to the cathode catalyst layer), (e) the cathode catalyst layer (that performs the reaction 32 O2 + 6H+ + 6 e- = 3H 2O, (f) the cathode backing layer (that distributes oxygen from the cathode gas channel to the cathode catalyst layer and transports water formed in the cathode catalyst layer to the cathode gas channel), and (g) the cathode gas channel. The direct methanol fuel cell being modeled in this project is being developed primarily for low power applications (lap-tops, PDA's) and to a lesser extent for transportation applications (automobiles, fork-lifts). A major problem in DMFC's is methanol crossover from the anode to the cathode without any electrochemical reaction. (Abstract shortened by UMI.)
title: Unpacking the complexity of learning chemistry
title: an examination of student discourse in introductory chemistry
titleType: Subtitle
Creators: name: Nennig, Hannah Terese
Publisher: name: University of Iowa
Year: 2026

description: Learning environments that facilitate students to actively engage with content have been shown to promote learning across the science fields. These engaging learning environments help students interact with content more regularly, which supports students’ in making more meaningful connections with the world around them. However, facilitating these environments can be challenging and instructors could benefit from additional supports in getting students engaged in undergraduate science courses. My work qualitatively analyzes student conversations, classroom materials, and instructor facilitation in an active learning introductory undergraduate chemistry course to provide insights into how we can better support instructors and students. Student conversations were analyzed across multiple classes and compared to the classroom materials they worked on during these periods. From this analysis it was found that the materials provided to students overall supported collaborative and cognitively engaged student conversations on chemical concepts. However, the supportive nature of these materials had the potential to be completely dismantled, as seen in the analysis of student engagement in comparison to the facilitation of these classrooms by graduate teaching assistants. Given the major facilitation role graduate teaching assistants held, it was found their engagement with students either provided additional support to the course materials provided or shut down any sort of student engagement by continually talking and/or skipping assigned tasks. For this reason, a major implication of this work is designing better facilitator trainings that support graduate teaching assistants in helping students engage in introductory chemistry.
Vorsorgende Leistungen der Wasserversorger für den Gewässer- und Gesundheitsschutz
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Wasserversorgung
Gewässerschutz
Gesundheitsvorsorge

description: Wasserversorger erbringen in Deutschland über ihre Kernaufgaben hinaus eine Reihe von unverzichtbaren vorsorgenden Leistungen für den Umwelt- und Gesundheitsschutz. Diese im Aufgabenprofil der Wasserversorger zu erhalten, ist ein besonderes umwelt- und gesundheitspolitisches Anliegen. Deshalb haben das Bundesministerium für Umwelt, Naturschutz, Bau und Reaktorsicherheit (BMUB) und das Bundesministerium für Gesundheit (BMG) gemeinsam mit den Branchenverbänden BDEW, DVGW und VKU einen Katalog der vorsorgenden Leistungen, die Wasserversorger im Gewässer- und Gesundheitsschutz erbringen, entwickelt. Der Katalog wurde am 28. August 2014 im Bundesanzeiger veröffentlicht. Im Folgenden werden die Inhalte und Ziele des Kataloges erläutert sowie der Katalog selbst vorgestellt.
© www.di-verlag.de
Heterogeneous photocatalysis: Design and experimental characterization of a new photocatalytic reactor for wastewater treatment
Creators: name: Mercer, Sarah M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Chemical.
subject: Engineering, Sanitary and Municipal.
subject: Energy.

description: The objective of this study is to promote photocatalytic wastewater treatment by proposing a reactor design that employs a catalyst-coated, rotating, corrugated drum to increase the surface area, induce agitation and promote reactant and photon transfer to the surface. Corrugation profiles with surface areas ranging from 405 cm2 to 3650 cm2 were considered---the addition of corrugations improved the phenol degradation rate by up to 200%. Based on an analysis of rotational speed and initial pollutant concentration, the reaction was found to be limited by the kinetics at 20 ppm and 40 ppm, but limited by phenol transfer to the reaction sites at 5 ppm. Finally, Langmuir-Hinshelwood kinetics was applicable with an average phenol adsorption coefficient of 0.120 L/mg and an increasing overall reaction rate constant with surface area. Further studies are necessary for the industrial use of such a reactor design including treatment of wastewater with varying characteristics, reactor design scaling and the applicability of this design for solar-activated applications.
State-dependencies of learning across brain scales
Creators: name: Ritter, Petra
name: Born, Jan
name: Brecht, Michael
name: Dinse, Hubert R.
name: Heinemann, Uwe
name: Pleger, Burkhard
name: Schmitz, Dietmar
name: Schreiber, Susanne
name: Villringer, Arno
name: Kempter, Richard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Learning is a complex brain function operating on different time scales, from milliseconds to years, which induces enduring changes in brain dynamics. The brain also undergoes continuous “spontaneous” shifts in states, which, amongst others, are characterized by rhythmic activity of various frequencies. Besides the most obvious distinct modes of waking and sleep, wake-associated brain states comprise modulations of vigilance and attention. Recent findings show that certain brain states, particularly during sleep, are essential for learning and memory consolidation. Oscillatory activity plays a crucial role on several spatial scales, for example in plasticity at a synaptic level or in communication across brain areas. However, the underlying mechanisms and computational rules linking brain states and rhythms to learning, though relevant for our understanding of brain function and therapeutic approaches in brain disease, have not yet been elucidated. Here we review known mechanisms of how brain states mediate and modulate learning by their characteristic rhythmic signatures. To understand the critical interplay between brain states, brain rhythms, and learning processes, a wide range of experimental and theoretical work in animal models and human subjects from the single synapse to the large-scale cortical level needs to be integrated. By discussing results from experiments and theoretical approaches, we illuminate new avenues for utilizing neuronal learning mechanisms in developing tools and therapies, e.g., for stroke patients and to devise memory enhancement strategies for the elderly.
Development of High Performing 3D Printed Polymeric Cellular Structures for Wearable Impact Protection
Creators: name: Habib, Fatah Nasih
Publisher: name: Swinburne
Year: 2024

description: This research work is an attempt to exploit the advantages offered by the 3D printing technology to design and develop polymeric energy-absorbing cellular materials for use in human wearable impact protection with a focus on the elderly fall-related hip protection. The research results can be used to carefully design and tailor energy-absorbing cellular materials with the closest behaviour to the ideal energy absorber and superior to the currently used traditional stochastic foams. Furthermore, the research shows that 3D printing allows the optimisation of energy absorption of such materials by manipulating the geometric design parameters of their microstructures.
The effects of ceramide regulated bone morphogenetic protein 3 on adipocyte metabolism
Creators: name: Tran, Aaron
Publisher: name: University of Iowa
Year: 2024
Subjects: Bmp3
Bone Morphogenetic Protein 3
Ceramides
Overexpression
UCP1
Obesity

description: Obesity is responsible for the development of various metabolic diseases like type 2 diabetes and cardiovascular disease costing the US healthcare system $147 billion a year. Overnutrition in obesity leads to the excess accumulation of fats in tissues not suited for lipid storage. This spillover of fats into non-adipose tissues causes harmful effects in those tissues, a condition known as lipotoxicity. Ceramides are a class of sphingolipids that is synthesized under these obesogenic conditions and impairs insulin signaling and mitochondrial function. To better understand the downstream mechanisms of ceramides in adipose tissue, we used transcriptomic screens and identified a ceramide-regulated protein called Bone Morphogenetic Protein 3 (Bmp3). Bmp3 is known for its role in bone formation and embryonic development, but recently it has been found to be elevated in adipose tissue. PURPOSE: The purpose of this study is to determine the effects of ceramide-regulated Bone Morphogenetic Protein 3 in adipocyte metabolism as well as in energy and glucose homeostasis. METHODS: We generated a new mouse model to overexpress Bmp3. We generated an adeno-associated virus (AAV) that encodes the full length of mouse Bmp3 or enhanced green fluorescent protein (eGFP) under a human thyroxine-binding globulin (TBG) promoter. Six-week-old C57BL/6J male mice were injected with 1x1011 particles through retro-orbital injection to help induce force production of Bmp3. These overexpression mice were subjected to experiments under sub-chronic and chronic conditions to observe the effects of Bmp3 on adipose tissue homeostasis as well as energy and glucose metabolism. We also generated an inducible UCP1+ thermogenic adipocyte-specific loss-of-function mice for Bmp3 to observe the effects of Bmp3 on thermogenic genes. RESULTS: Our findings show that Bmp3 is sufficient to impair thermogenesis and glucose and energy homeostasis in obese mice. Moreover, we find that ablation of Bmp3 in Ucp1+ thermogenic adipocytes improves energy and glucose homeostasis. DISCUSSION: Currently, ceramide regulation of Bmp3 is poorly understood with no known studies on Bmp3 in adipose tissue. Our findings indicate that Bmp3 regulates adipose homeostasis and obesity by negatively regulating adaptive thermogenesis.
Electrical Impedance Tomography for deformable media
Creators: name: Gomez-Laberge, Camille
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: In Electrical Impedance Tomography (EIT), electrical energy is applied and measured at the boundary of a medium to produce an image of its internal conductivity distribution. When imaging pulmonary ventilation, rib cage expansion and body posture introduce severe image artefacts in the reconstructed images due to electrode position error. This thesis proposes a method to reduce such artefacts by determining the net displacement of electrodes between measurement frames, and effectively, adjusting the geometry of the reconstruction model. A novel regularization method is proposed and validated using data acquired from simulation, phantom, and human in vivo measurements. The proposed method reduces artefacts by more than 70% in simulated reconstructions and phantom experiments. The in vivo images reveal the various breathing manoeuvres and thoracic movements recorded. Furthermore, the displacement of each electrode is calculated, indicating the deformed boundary shape. This thesis supports EIT for clinical diagnostics and monitoring of pulmonary ventilation.
Accelerating the scalar multiplication on elliptic curve cryptosystems over prime fields
Creators: name: Longa, Patrick
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: Elliptic curve cryptography (ECC), independently introduced by Koblitz and Miller in the 80's, has attracted increasing attention in recent years due to its shorter key length requirement in comparison with other public-key cryptosystems such as RSA. Shorter key length means reduced power consumption and computing effort, and less storage requirement, factors that are fundamental in ubiquitous portable devices such as PDAs, cellphones, smartcards, and many others. To that end, a lot of research has been carried out to speed-up and improve ECC implementations, mainly focusing on the most important and time-consuming ECC operation: scalar multiplication. In this thesis, we focus in optimizing such ECC operation at the point and scalar arithmetic levels, specifically targeting standard curves over prime fields. At the point arithmetic level, we introduce two innovative methodologies to accelerate ECC formulae: the use of new composite operations, which are built on top of basic point doubling and addition operations; and the substitution of field multiplications by squarings and other cheaper operations. These techniques are efficiently exploited, individually or jointly, in several contexts: to accelerate computation of scalar multiplications, and the computation of pre-computed points for window-based scalar multiplications (up to 30% improvement in comparison with previous best method); to speed-up computations of simple side-channel attack (SSCA)-protected implementations using innovative atomic structures (up to 22% improvement in comparison with scalar multiplication using original atomic structures); and to develop parallel formulae for SIMD-based applications, which are able to execute three and four operations simultaneously (up to 72% of improvement in comparison with a sequential scalar multiplication). At the scalar arithmetic level, we develop new sublinear (in terms of Hamming weight) multibase scalar multiplications based on NAF-like conversion algorithms that are shown to be faster than any previous scalar multiplication method. For instance, proposed multibase scalar multiplications reduce computing times in 10.9% and 25.3% in comparison with traditional NAF for unprotected and SSCA-protected scenarios, respectively. Moreover, our conversion algorithms overcome the problem of converting any integer to multibase representation, solving an open problem that was defined as hard. Thus, our algorithms make the use of multiple bases practical for applications as ECC scalar multiplication for first time.
Experiences of children with chronic illness: A qualitative evaluation of a children's mental skills program.
Creators: name: Koudys, Julie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Mental Health.

description: Children with chronic illness are confronted with a variety of acute and chronic stressors. As a result, they require coping strategies that can be used successfully during extremely stressful situations. Mental skills training programs teach children stress management and relaxation techniques that may be used during stressful encounters. The primary purpose of this multiple case study was to evaluate the effectiveness of Orlick's Feeling Great Program in teaching children with chronic illness to deal successfully with stress and find highlights. Qualitative research methods were used to explore factors related to the process of learning mental skills, including types of skills used most often, the influence of context, and factors that effect skill development. Four children receiving treatment for cancer between the ages of 7--9 learned techniques such as muscle relaxation, diaphragm breathing and imagery. Data collection included participant observation, field notes, interview data and highlight journals. Program participants perceived the program to be effective in fostering the development of improved coping skills for use within a variety of situations. During acute stressors, such as painful medical procedures, children and parents reported fewer incidents of reactive coping behaviors, such as crying, and described an increased number of proactive coping responses, such as deep breathing. Furthermore, children learned to cope effectively with chronic stressors, such as feelings of anxiety, nausea and treatment side effects.
Final Reporting on OMERO and ARC Integration - BioHackathon Germany 2023
Creators: name: Kandpal, Niraj
name: Schrader, Andrea
name: Stöter, Torsten
name: Moore, Josh
name: Bortolomeazzi, Michele
name: Schneider, Kevin
name: Burel, Jean-marie
name: Dahms, Eik
name: Abdrabbou, Mohamed M.
name: Boissonnet, Tom
name: Zentis, Peter
Publisher: name: Zenodo
Year: 2024

description: Final reporting at BioHackathon Germany 2023 with contributing slides from all the co-authors on different sub-topics within OMERO and ARC Integration project.
Protein kinase C (PKC) amplifies the hormonal stimulation of adenylate cyclase in T51B rat liver cells.
Creators: name: Aasheim, Lise H.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Chemistry, Biochemistry.

description: Membrane signalling is a process that is fundamental to the response of cells to extracellular stimuli. Two major pathways are used to generate intracellular "second messengers" in response to hormonal stimulation. They are the production of cAMP and hydrolysis of membrane phospholipids to produce inositol-1,4,5-trisphosphate and diacylglycerol. Recent evidence indicates that these two membrane signalling systems interact with one another. Activation of PKC by phorbol esters (TPA) results in a modification of the cAMP system leading to either attenuation or amplification of the cyclic AMP signal. It has been shown that TPA inhibits glucagon-stimulated adenylate cyclase activity in rat hepatocytes. In the non-neoplastic T51B rat liver cell line, TPA, when added to intact cells, had no effect on the basal level of cyclic AMP synthesis but caused a 1.5 fold amplification of the stimulation induced by $\beta$-adrenergic agents, cholera toxin and forskolin. The same concentration of TPA also caused translocation of PKC from the cytosolic fraction. The time course for the translocation is longer than the time course found for the enhancement of adenylate cyclase activity. The effect of TPA treatment seen in this tissue culture system appears to be activation of membrane associated PKC rather than translocation. Activation of PKC already present in the membrane is likely to cause a change in adenylate cyclase activity.
Concepts of happiness: The influence of Ludwig Feuerbach on the fiction of George Eliot.
Creators: name: Bradshaw, Jennifer Mary.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Philosophy.

description: The search for happiness is a vital theme in George Eliot's fiction. Eliot's treatment of this theme owes much to nineteenth-century utilitarianism, which stemmed from Jeremy Bentham's "greatest happiness principle," and the religious demythologization of the German philosopher Ludwig Feuerbach, who interpreted Christianity in terms of human consciousness. In 1854, Eliot translated Feuerbach's Das Wesen des Christenthums, in which Feuerbach describes the components of man's being as feeling, thinking, and willing. George Eliot saw an opposition between utilitarianism and Feuerbach's humanism. This fact is fundamental for our understanding of the rhetorical structure of Eliot's moral universe. In her fiction, utilitarianism as utility, the pursuit of pleasure, utility, avoidance of pain, and calculation of pleasure over pain (the "felicific calculus") is shown by her, paradoxically, often to lead to wrongdoing, suffering, and even crime. For some of her protagonists, however, it contributes to a primary stage of their development, since their consequent suffering may lead to a greater awareness. The movement from suffering to sympathy in Eliot's novels is profoundly Feuerbachian, for it involves the "essence" of Christianity which he described as man's essential nature. Despite her scepticism as to the efficacy of Bentham's principle of utility, Eliot endorsed the utilitarian principle of consequences as a fundamental aspect of her ethic. A detailed analysis of the way in which Eliot counterpoints utilitarianism with Feuerbach's ethic in Scenes of Clerical Life, Adam Bede, "The Lifted Veil," The Mill on the Floss, Silas Marner, "Brother Jacob," Romola, Felix Holt, Middlemarch, and Daniel Deronda demonstrates that, in Eliot's fiction, true self-fulfilment, involving moral freedom, is consistently derived from adherence to the fundamental laws of human nature, as embodied in Feuerbach's particular description of the human "essence." Although other philosophical and psychological influences can be discerned, certain characteristics of Eliot's fiction, such as the melange of idealism and an abiding sense of human limitation and alienation, may be traced to her confrontation with utilitarianism through a Feuerbachian morality.
Cloning and nucleotide sequence analysis of the P3 region of enterovirus 70.
Creators: name: Sattar Sheikh, Ahsan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Microbiology.

description: In this study, nucleotide and amino acid sequence analyses were conducted in the P3 region of the Enterovirus 70 genome. Nucleotide and amino acid sequence alignments show that Enterovirus 70 is a picornavirus and is closely related to polioviruses and coxsackieviruses. The 3D$\sp{\rm pol}$ and 3B(VPg) of Enterovirus 70 show higher similarity to the corresponding regions of Poliovirus 1, while two other regions, 3A and 3C$\sp{\rm pro}$, are more closely related to Coxsackievirus B3 sequences. These observations suggest that the P3 region of Enterovirus 70 diverged from poliovirus like sequences. For the two regions which show more similarity to Coxsackievirus B3 like sequences, there is some evidence that this could be the result of recombination, in the P3 region, between an the ancestral sequence to Enterovirus 70 and a coxsackievirus like genome. The importance of the P3 region in transcription, translation, and replication suggests that these recombinational events may be responsible for some of the biological properties of Enterovirus 70, particularly its temperature sensitive nature and broader host range. (Abstract shortened by UMI.)
Leaving patients to their own devices? Smart technology, safety and therapeutic relationships
Creators: name: Ho, Anita
name: Quick, Oliver
Publisher: name: BioMed Central
Year: 2018

description: Background: This debate article explores how smart technologies may create a double-edged sword for patient safety and effective therapeutic relationships. Increasing utilization of health monitoring devices by patients will likely become an important aspect of self-care and preventive medicine. It may also help to enhance accurate symptom reports, diagnoses, and prompt referral to specialist care where appropriate. However, the development, marketing, and use of such technology raise significant ethical implications for therapeutic relationships and patient safety. Main text: Drawing on lessons learned from other direct-to-consumer health products such as genetic testing, this article explores how smart technology can also pose regulatory challenges and encourage overutilization of healthcare services. In order for smart technology to promote safer care and effective therapeutic encounters, the technology and its utilization must be safe. Conclusion: This article argues for unified regulatory guidelines and better education for both healthcare providers and patients regarding the benefits and risks of these devices.
Security Evaluation in Software-Defined Networks
Creators: name: Ivkić, Igor
name: Thiede, Dominik
name: Race, Nicholas
name: Broadbent, Matthew
name: Gouglidis, Antonios
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cryptography and Security (cs.CR)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Cloud computing has grown in importance in recent years which has led to a significant increase in Data Centre (DC) network requirements. A major driver of this change is virtualisation, which allows computing resources to be deployed on a large scale. However, traditional DCs, with their network topology and proliferation of network endpoints, are struggling to meet the flexible, centrally managed requirements of cloud computing applications. Software-Defined Networks (SDN) promise to offer a solution to these growing networking requirements by separating control functions from data routing. This shift adds more flexibility to networks but also introduces new security issues. This article presents a framework for evaluating security of SDN architectures. In addition, through an experimental study, we demonstrate how this framework can identify the threats and vulnerabilities, calculate their risks and severity, and provide the necessary measures to mitigate them. The proposed framework helps administrators to evaluate SDN security, address identified threats and meet network security requirements.
description: pp. 66-91