cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise
Creators: name: MA Sallam
name: KA Sheikh
name: R Baxendale
name: Azam, Mohammad
name: M El-Setouhy
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2016 Sallam et al. Background: Khat (Catha Edulis Forsk) is a natural psychoactive substance that contains addictive substances such as Cathine and Cathinone which have similar structure and action to amphetamine. This substance has been suggested that it can decrease perceived exertion and thus improve performance. There is no study in the literature regarding the effect of khat on exercise performance. Therefore, the aim of this study is to find out whether khat leaves can decrease perceived exertion in humans. Methods: This study is an experimental crossover study conducted at the Substance Abuse Research Centre in Jazan University, Saudi Arabia. Twenty one healthy volunteers were randomly assigned into two experiment trials. Each volunteer visited the lab three times. The first visit was a familiarization session about the nature of the study and the equipment. On the second visit, 45 min before the experiment volunteers ingested either 33 ml of fruit juice (placebo) or the juice mixed with 45 g of ground khat leaves. Then the participants were instructed to perform a 10 Km cycling on an ergometer and recorded the following physiological variables repeatedly on every 5 min of cycling: heart rate, time to complete 10 km cycling, tympanic temperature, and perceived exertion rate. On the third visit a crossover trial was conducted one week after the second visit; then the same cycling test was performed and the same variables were recorded as the second visit. The experimental protocol was reviewed and approved by Research Ethical Committee of the Medical Research Centre, Jazan University. Results: According to study results, khat dramatically decreased time taken to complete a 10 km cycling time trail (p < 0.05), and significantly increased heart rate (p < 0.05) and tympanic temperature (p < 0.01). However, khat did not reduce participant's perceived exertion during the physical trial. The Bonferrini simultaneous confidence intervals using multivariate Hotelling's T2 was performed to test the significance of the mean vectors for the placebo group and the Khat group and found that groups are statistically significant. Conclusions: Khat showed a clear enhancing effect on physical performance. The most parsimonious explanation for this effect is that, like the related amphetamines, cathine/cathinone act as stimulants to increase the capacity to perform exercise. Thus, khat produces the same effects which lead to the banning of amphetamine. These findings conform & endorse the recent prohibition of cathinone by the World Anti-Doping Agency (WADA, 2014).
Additional file 1 of Correlation between immune-related adverse events and efficacy of PD-(L)1 inhibitors in small cell lung cancer: a multi-center retrospective study
Creators: name: Zhang, Jian
name: Gao, Aiqin
name: Wang, Shuyun
name: Sun, Yanxin
name: Wu, Jiake
name: Wang, Dahai
name: Ge, Yihui
name: Li, Juan
name: Sun, Haifeng
name: Cheng, Qinglei
name: Sun, Yuping
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Additional file 1 of A qualitative study to explore the burden of disease in activated phosphoinositide 3-kinase delta syndrome (APDS)
Creators: name: Hitchcock, Ian
name: Skrobanski, Hanna
name: Matter, Elina
name: Munro, Ewen
name: Whalen, John
name: Nolthenius, Joanne Tutein
name: Crocker-Buque, Alex
name: Harrington, Amanda
name: Vandenberghe, Delphine
name: Acaster, Sarah
name: Williams, Kate
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Additional Material 1. HCP Interview findings. Exemplary quotes from HCPS describing their experiences with APDS.
Cantharellus littoralis Buyck 2020, comb. et stat. nov.
Creators: name: Buyck, Bart
name: Ndolo, Sydney T.
name: Ebika
name: Kesel, André De
name: Hofstetter, Valérie
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Fungi
Basidiomycota
Agaricomycetes
Cantharellales
Cantharellaceae
Cantharellus
Cantharellus littoralis

description: Cantharellus littoralis (Buyck & Randrianjohany) Buyck, comb. et stat. nov.
 Cantharellus longisporus subsp. littoralis Buyck & Randrianjohany, Cryptogamie, Mycologie 33 (2): 173 (2012) (basionym).
 Cantharellus cyanoxanthus Heim, Traité de Pathologie exotique vétérinaire et comparée 3: 301 (1936), nom. inval.
MYCOBANK. — MB 835033.
description: Published as part of Buyck, Bart, Ndolo, Sydney T., Ebika, Kesel, André De & Hofstetter, Valérie, 2020, Tropical African Cantharellus Adans.: Fr. (Hydnaceae, Cantharellales) with lilac-purplish tinges revisited, pp. 161-177 in Cryptogamie, Mycologie 20 (10) on page 169, DOI: 10.5252/cryptogamie-mycologie2020v41a10, http://zenodo.org/record/12214831
sj-docx-1-eae-10.1177_0958305X221140582 - Supplemental material for Quantifying the excess carbon footprint and its main determinants of Spanish households
Creators: name: Mahía, Ramón
name: de Arce, Rafael
Publisher: name: SAGE Journals
Year: 2022
Subjects: Geography

description: Supplemental material, sj-docx-1-eae-10.1177_0958305X221140582 for Quantifying the excess carbon footprint and its main determinants of Spanish households by Ramón Mahía and Rafael de Arce in Energy & Environment
sj-pdf-1-psx-10.1177_00323217221137444 – Supplemental material for Scaling Up? Unpacking the Effect of Deliberative Mini-Publics on Legitimacy Perceptions
Creators: name: Germann, Micha
name: Marien, Sofie
name: Muradova, Lala
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-pdf-1-psx-10.1177_00323217221137444 for Scaling Up? Unpacking the Effect of Deliberative Mini-Publics on Legitimacy Perceptions by Micha Germann, Sofie Marien and Lala Muradova in Political Studies
Additional file 2 of A qualitative study to explore the burden of disease in activated phosphoinositide 3-kinase delta syndrome (APDS)
Creators: name: Hitchcock, Ian
name: Skrobanski, Hanna
name: Matter, Elina
name: Munro, Ewen
name: Whalen, John
name: Nolthenius, Joanne Tutein
name: Crocker-Buque, Alex
name: Harrington, Amanda
name: Vandenberghe, Delphine
name: Acaster, Sarah
name: Williams, Kate
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 2: Additional Material 2. Patient/Caregiver narrative account findings. Exemplary quotes from patients and caregivers describing their experiences with APDS.
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments
Creators: name: C Peng
name: AG Stewart
name: OL Woodman
name: Ritchie, Rebecca
name: CX Qin
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Peng, Stewart, Woodman, Ritchie and Qin. Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of NAFLD patients are estimated to have NASH. NASH is typically characterized by liver steatosis inflammation, and fibrosis driven by metabolic disruptions such as obesity, diabetes, and dyslipidemia. NASH patients with significant fibrosis have increased risk of developing cirrhosis and liver failure. Currently, NASH is the second leading cause for liver transplant in the United States. More importantly, the risk of developing hepatocellular carcinoma from NASH has also been highlighted in recent studies. Patients may have NAFLD for years before progressing into NASH. Although the pathogenesis of NASH is not completely understood, the current “multiple-hits” hypothesis suggests that in addition to fat accumulation, elevated oxidative and ER stress may also drive liver inflammation and fibrosis. The development of clinically relevant animal models and pharmacological treatments for NASH have been hampered by the limited understanding of the disease mechanism and a lack of sensitive, non-invasive diagnostic tools. Currently, most pre-clinical animal models are divided into three main groups which includes: genetic models, diet-induced, and toxin + diet-induced animal models. Although dietary models mimic the natural course of NASH in humans, the models often only induce mild liver injury. Many genetic and toxin + diet-induced models rapidly induce the development of metabolic disruption and serious liver injury, but not without their own shortcomings. This review provides an overview of the “multiple-hits” hypothesis and an evaluation of the currently existing animal models of NASH. This review also provides an update on the available interventions for managing NASH as well as pharmacological agents that are currently undergoing clinical trials for the treatment of NASH.
title: Die deutsche Volksgruppe in Ungarn von der Ansiedlung bis zur Vertreibung
Creators: name: Steiner, Birgit
Year: 2010

description: Die Arbeit beschäftigt sich mit der Geschichte der deutschen Volksgruppe in Ungarn von der Ansiedlung bis zur Vertreibung. Mit Kriegsende wurde die Jahrhunderte lange Anwesenheit der Deutschen in Ungarn in Frage gestellt. Mit dieser Infragestellung kam es zur Eskalation eines aggressiven Verhaltens gegenüber der ungarndeutschen Bevölkerung. Die offizielle Politik stempelte die Ungarndeutschen als Kollaborateure ab und machte sie für die Unterwerfung Ungarns unter die nationalsozialistische Herrschaft verantwortlich. Die Vertreibung und Aussiedlung der Deutschen aus Ostmittel- und Südosteuropa war somit einerseits die Antwort auf das nationalsozialistische Regime, andererseits aber vor allem das Resultat des über Jahrhunderte konkurrierenden Verhältnisses zwischen Staatsnation, die von einem ungarischen Nationalismus beeinflusst wurde, und einer Minderheit, die sich während des Zweiten Weltkrieges den Einwirkungen des Deutschen Reiches nicht entziehen konnte. Doch der ständig anhaltende "Diaspora-Charakter" der deutschen Minderheit war nur bedingt für die Vertreibung der Ungarndeutschen verantwortlich. Auch die teilweise fehlende direkte Verbindung zum deutschsprachigen Raum, die zersplitterte Siedlungsstruktur und die politisch passive Haltung der Ungarndeutschen bedingten ihre Vertreibung. Auch die Pariser Friedensverträge nach dem Zweiten Weltkrieg basierten auf dem Prinzip eines einheitlichen nationalen Staates und einer "Lösung des Nationalitätenproblems" durch eine zwangsverordnete Umsiedlung. Die deutsche Bevölkerung Ungarns war bis 1948 von der Anwendung des Prinzips der Kollektivschuld und der Zwangsaussiedlung betroffen.
NSCLCGUT2019ANTIPD1
Creators: name: 方超(Chao Fang)
Publisher: name: CNGB
Year: 2022
Subjects: Metagenome
Multispecies

description: Background: Programmed death 1 (PD-1) and the ligand of PD-1 (PD-L1) are central targets for immune-checkpoint therapy (ICT) blocking immune evasion-related pathways elicited by tumor cells. A number of PD-1 inhibitors have been developed, but the efficacy of these inhibitor varies considerably and is typically below 50%. The efficacy of ICT has been shown to be dependent on the gut microbiota, and experiments using mouse models have even demonstrated that modulation of the gut microbiota may improve efficacy of ICT. Methods: We followed a Han Chinese cohort of 85 advanced non-small cell lung cancer (NSCLC) patients, who received anti-PD-1 antibodies. Tumor biopsies were collected before treatment initiation for whole exon sequencing and variants detection. Fecal samples collected biweekly during the period of anti-PD-1 antibody administration were used for metagenomics sequencing. We established gut microbiome abundance profiles for identification of significant associations between specific microbial taxa, potential functionality, and treatment responses. A prediction model based on random forest was trained using selected markers discriminating between the different response groups. Results: NSCLC patients treated with antibiotics exhibited the shortest survival time. Low level of tumor-mutation burden and high expression level of HLA-E significantly reduced progression-free survival. We identified metagenomic species and functional pathways that differed in abundance in relation to responses to ICT. Data on differential enrichment of taxa and predicted microbial functions in NSCLC patients responding or non-responding to ICT allowed the establishment of random forest algorithm adopted models robustly predicting the probability of whether or not a given patient would benefit from ICT. Conclusions: Overall, our results identified links between gut microbial composition and immunotherapy efficacy in Chinese NSCLC patients indicating the potential for such analyses to predict outcome prior to ICT.
Electroactive biofilms on surface functionalized anodes: the anode respiring behavior of a novel electroactive bacterium, Desulfuromonas acetexigens
Creators: name: KP Katuri
name: S Kamireddy
name: P Kavanagh
name: A Muhammad
name: Conghaile, Peter O
name: A Kumar
name: PE Saikaly
name: D Leech
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Surface chemistry is known to influence the formation, composition, and electroactivity of electron-conducting biofilms. However, understanding of the evolution of microbial composition during biofilm development and its impact on the electrochemical response is limited. Here we present voltammetric, microscopic and microbial community analysis of biofilms formed under fixed applied potential for modified graphite electrodes during early (90 h) and mature (340 h) growth phases. Electrodes modified to introduce hydrophilic groups (-NH2, -COOH and -OH) enhance early-stage biofilm formation compared to unmodified or electrodes modified with hydrophobic groups (-C2H5). In addition, early-stage films formed on hydrophilic electrodes are dominated by the gram-negative sulfur-reducing bacterium Desulfuromonas acetexigens while Geobacter sp. dominates on -C2H5 and unmodified electrodes. As biofilms mature, current generation becomes similar, and D. acetexigens dominates in all biofilms irrespective of surface chemistry. Electrochemistry of pure culture D. acetexigens biofilms reveal that this microbe is capable of forming electroactive biofilms producing considerable current density of > 9 A/m2 in a short period of potential-induced growth (~19 h following inoculation) using acetate as an electron donor. The inability of D. acetexigens biofilms to use H2 as a sole source electron donor for current generation shows promise for maximizing H2 recovery in single-chambered microbial electrolysis cell systems treating wastewaters.
OS DESAFIOS DA REGULAÇÃO
Creators: name: Simões, Jorge
name: Carneiro, César
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: A OECD define regulação económica como a imposição de regras pelos governos, apoiada pelo uso de sanções que visam, especificamente, modificar o comportamento económico de indivíduos e empresas. As importantes falhas ident ificadas nos mercados de seguros de saúde e de prestação de cuidados de saúde fazem com que este seja um dos campos clássicos da intervenção regulatória. Com efeito, as at ividades de regulação da saúde estão presentes na generalidade dos sistemas de saúde contemporâneos, embora sob formas nem sempre explícitas e devidamente estruturadas e autonomizadas. Porém, o grau de disseminação da regulação da saúde não encont ra proporcionalidade no grau de consenso político, social ou académico em torno de muitos dos seus aspetos cent rais. As discussões principais cent ram-se, atualmente, não na necessidade da existência de regulação da saúde, mas em aspetos part iculares como o grau de independência face ao governo e aos agentes dos mercados, os custos diretos e indiretos da at ividade de regulação ou a escolha entre regulação do sistema e autorregulação por profissionais de saúde. Em Portugal, a regulação independente da saúde surgiu em 2003 e, não obstante as dificuldades iniciais de aceitação por parte dos stakeholders, esta forma de intervenção pública nas at ividades de saúde assume, hoje, um papel fulcral no sistema de saúde português.
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
O ENSINO DAS CIÊNCIAS MÉDICAS E BIOMÉDICAS NO INSTITUTO DE HIGIENE E MEDICINA TROPICAL – A CONTEXTUALIZAÇÃO HISTÓRICO-PEDAGÓGICO
Creators: name: Viveiros, Miguel
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
title: An economic analysis of public cultural subsidies
Creators: name: Renner, Anna-Theresa
Year: 2010

description: Diese Diplomarbeit beschäftigt sich mit der finanziellen Unterstützung von kulturellen Einrichtungen und künstlerischen Tätigkeitsfeldern, wobei ein Schwerpunkt auf die öffentliche Subventionierung von kulturellen Institutionen gelegt wird. Die Arbeit diskutiert die verschiedenen Möglichkeiten öffentlicher und privater Unterstützung und die Gründe derselben.Die messbaren ökonomischen Effekte des Kultursektors im Allgemeinen und von bestimmten Institutionen im Besonderen können durch eine Input-Output Analyse erfasst werden. Diese wird in einem Abschnitt der Arbeit vorgestellt und in einem anderen auf die Wiener Staatsoper angewandt. So soll die wirtschaftliche Bedeutung des Opernhauses für die österreichische Volkswirtschaft sichtbar gemacht werden.
description: This thesis examines the financial support for cultural institutions and artistic activities in general and concentrates in particular on public subsidies for arts institutions. The work discusses the various methods of and the reasons for governmental and private support to the arts.To estimate the measurable economic effects of the cultural sector and of specific cultural institutions the Input-Output system is introduced as methodological background. In the last part of this work the economic effects of the Wiener Staatsoper are calculated and analyzed to underline the significance of cultural institutions for the national economy.
Mediterranean diet decreases the initiation of use of vitamin K epoxide reductase inhibitors and their associated cardiovascular risk: a randomized controlled trial
Creators: name: Castro-Barquero, Sara
name: Ribó-Coll, Margarita
name: Lassale, Camille
name: Tresserra-Rimbau, Anna
name: Castañer, Olga
name: Pintó, Xavier
name: Martinez-Gonzalez, Miguel
name: Sorlí, José V
name: Salas-Salvadó, Jordi
name: Lapetra, José
name: Gómez-Gracia, Enrique
name: Alonso-Gómez, Ángel M
name: Fiol, Miquel
name: Serra-Majem, Lluis
name: Sacanella, Emilio
name: Basterra-Gortari, Francisco Javier
name: Portolés, Olga
name: Babio, Nancy
name: Cofán, Montserrat
name: Ros, Emilio
name: Estruch, Ramón
name: Hernáez, Álvaro
Publisher: name: La Trobe
Year: 2021

description: Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46-0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92-9.30], HRMedDiets: 1.71 [0.83-3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
sj-docx-1-jdr-10.1177_00220345221138532 – Supplemental material for The Longitudinal Relationship between Jaw Catching/Locking and Pain
Creators: name: Ilgunas, A.
name: Häggman-Henrikson, B.
name: Visscher, C.M.
name: Lobbezoo, F.
name: Durham, J.
name: Liv, P.
name: Lövgren, A.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-jdr-10.1177_00220345221138532 for The Longitudinal Relationship between Jaw Catching/Locking and Pain by A. Ilgunas, B. Häggman-Henrikson, C.M. Visscher, F. Lobbezoo, J. Durham, P. Liv and A. Lövgren in Journal of Dental Research
Comparative analysis of the lignification process of two bamboo shoots stored at room temperature
Creators: name: Z Zhang
name: C Li
name: H Zhang
name: Y Ying
name: Y Hu
name: Song, Lili
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Two types of bamboo shoots, high bamboo (Phyllostachys prominens) shoots (HBSes) and moso bamboo (Phyllostachys edulis) shoots (MBSes), underwent a fast post-harvest lignification process under room temperature storage. To explore the mechanism of lignification in two types of bamboo shoots after post-harvest during room temperature storage, the measurement of cell wall polymers (lignin and cellulose) and enzyme activities of phenylalanine ammonialyase (PAL) and peroxidase (POD), and relative expression of related transcription networks factors (TFs) were performed. The results suggested that the lignification process in HBSes is faster than that in MBSes because of incremental increase in lignin and cellulose contents within 6 days and the shorter shelf-life. Additionally, compared with the expression pattern of lignification-related TFs and correlation analysis of lignin and cellulose contents, MYB20, MYB43, MYB85 could function positively in the lignification process of two types of bamboo shoots. A negative regulator, KNAT7, could negatively regulate the lignin biosynthesis in two types of bamboo shoots. In addition, MYB63 could function positively in HBSes, and NST1 could function negatively in MBSes. Notably, MYB42 may function differently in the two types of bamboo shoots, that is, a positive regulator in HBSes, but a negative regulator in MBSes. Transcription networks provide a comprehensive analysis to explore the mechanism of lignification in two types of bamboo shoots after post-harvest during room temperature storage. These results suggest that the lignification of bamboo shoots was mainly due to the increased activity of POD, higher expression levels of MYB20, MYB43, MYB63, and MYB85 genes, and lower expression levels of KNAT7 and NST1 genes, and the lignification process of HBSes and MBSes had significant differences.
sj-docx-1-psp-10.1177_01461672221115218 – Supplemental material for Lordosis in Humans
Creators: name: Yesim Semchenko, Ayten
name: Senveli, Zeynep
name: Forrest, Mitchell R. L.
name: Flores, Jonathon
name: Fiala, Vojtěch
name: Al-Shawaf, Laith
name: Buss, David M.
name: Lewis, David M. G.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-psp-10.1177_01461672221115218 for Lordosis in Humans by Ayten Yesim Semchenko, Zeynep Senveli, Mitchell R. L. Forrest, Jonathon Flores, Vojtěch Fiala, Laith Al-Shawaf, David M. Buss and David M. G. Lewis in Personality and Social Psychology Bulletin
Accessibility Of Repository Content: Successes And Failures
Creators: name: Lyon, Colleen
Publisher: name: Zenodo
Year: 2018
Subjects: accessibility
institutional repositories
captioning

description: In spring 2017, events external to the university made us aware there were likely some accessibility issues with the audio and video content in our DSpace repository, Texas ScholarWorks. This poster explains how we’ve addressed this issue so far and what remains to be done.
A community-based co-designed genetic health service model for Aboriginal Australians
Creators: name: Elsum, I
name: Massey, L
name: McEwan, C
name: LaGrappe, Desireé
name: Kowal, E
name: Savarirayan, R
name: Baynam, G
name: Jenkins, Misty
name: Garvey, G
name: Kelaher, M
Publisher: name: La Trobe
Year: 2023

description: © 2020 Elsum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Aboriginal and Torres Strait Islander people experience a greater burden of disease and die younger than non-Indigenous Australians, with Aboriginal people living in remote areas of the Northern Territory of Australia having the lowest life expectancy estimates. Despite a high burden of chronic disease among Aboriginal and Torres Strait Islander people, access to specialist health services remains low and models of care that increase engagement, may improve health outcomes. Methods We describe client and staff perspectives of a model of clinical genetics services provided by the MJD Foundation (MJDF) in geographically and culturally complex contexts within the Northern Territory of Australia. We seek to understand the MJDF model’s success in supporting Aboriginal families with the familial, neurodegenerative condition Machado-Joseph disease and how it could be applied in the provision of other specialist services. Thematic analysis was undertaken on semi-structured interviews with primary health care staff (n = 2), Non-Aboriginal MJDF Staff (n = 7) and Aboriginal MJDF Clients / Community workers (n = 13). Results Four key themes regarding the MJDF model of service delivery were identified with the service being; 1) client led 2) accepting of various understandings of genetic disease causation 3) focused on relationships, continuity and trust between the service provider and the clients, and 4) committed to incorporating an inclusive whole-of-family practice. The MJDF model takes a community-based, person-and family-centred approach to successfully deliver effective specialist genetic health services in remote community settings. We propose that these approaches have broad application in the future design and delivery of specialist health services particularly in culturally complex settings.
A community-based co-designed genetic health service model for Aboriginal Australians
Creators: name: I Elsum
name: L Massey
name: C McEwan
name: D LaGrappe
name: E Kowal
name: R Savarirayan
name: G Baynam
name: Jenkins, Misty
name: G Garvey
name: M Kelaher
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Elsum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Aboriginal and Torres Strait Islander people experience a greater burden of disease and die younger than non-Indigenous Australians, with Aboriginal people living in remote areas of the Northern Territory of Australia having the lowest life expectancy estimates. Despite a high burden of chronic disease among Aboriginal and Torres Strait Islander people, access to specialist health services remains low and models of care that increase engagement, may improve health outcomes. Methods We describe client and staff perspectives of a model of clinical genetics services provided by the MJD Foundation (MJDF) in geographically and culturally complex contexts within the Northern Territory of Australia. We seek to understand the MJDF model’s success in supporting Aboriginal families with the familial, neurodegenerative condition Machado-Joseph disease and how it could be applied in the provision of other specialist services. Thematic analysis was undertaken on semi-structured interviews with primary health care staff (n = 2), Non-Aboriginal MJDF Staff (n = 7) and Aboriginal MJDF Clients / Community workers (n = 13). Results Four key themes regarding the MJDF model of service delivery were identified with the service being; 1) client led 2) accepting of various understandings of genetic disease causation 3) focused on relationships, continuity and trust between the service provider and the clients, and 4) committed to incorporating an inclusive whole-of-family practice. The MJDF model takes a community-based, person-and family-centred approach to successfully deliver effective specialist genetic health services in remote community settings. We propose that these approaches have broad application in the future design and delivery of specialist health services particularly in culturally complex settings.
Metabolomic biomarkers of Multiple Sclerosis: a systematic review
Creators: name: L Porter
name: A Shoushtarizadeh
name: GA Jelinek
name: CR Brown
name: CK Lim
name: Livera, Alysha De
name: KR Jacobs
name: TJ Weiland
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Porter, Shoushtarizadeh, Jelinek, Brown, Lim, de Livera, Jacobs and Weiland. Background: Magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, and the McDonald’s clinical criteria are currently utilized tools in diagnosing multiple sclerosis. However, a more conclusive, consistent, and efficient way of diagnosing multiple sclerosis (MS) is yet to be discovered. A potential biomarker, discovered using advances in high-throughput sequencing such as nuclear magnetic resonance (NMR) spectroscopy and other “Omics”-based techniques, may make diagnosis and prognosis more reliable resulting in a more personalized and targeted treatment regime and improved outcomes. The aim of this review was to systematically search the literature for potential biomarkers from any bodily fluid that could consistently and accurately diagnose MS and/or indicate disease progression. Methods: A systematic literature review of EMBASE, PubMed (MEDLINE), The Cochrane Library, and CINAHL databases produced over a thousand potential studies. Inclusion criteria stated studies with potential biomarker outcomes for people with MS were to be included in the review. Studies were limited to those with human participants who had a clinically defined diagnosis of MS and published in English, with no limit placed on date of publication or the type of bodily fluid sampled. Results: A total of 1,805 studies were recorded from the literature search. A total of 1,760 studies were removed based on their abstract, with a further 18 removed after considering the full text. A total of 30 studies were considered relevant and had their data retrieved and analyzed. Due to the heterogeneity of focus and results from the refined studies, a narrative synthesis was favored. Conclusion: Several promising candidate biomarkers suitable for clinical application in MS have been studied. It is recommended follow-up studies with larger sample sizes be completed on several potential biomarkers.
Sarcopenia, diet, physical activity and obesity in European middle-aged and older adults: the LifeAge study
Creators: name: PJ Marcos-Pardo
name: N González-Gálvez
name: A López-Vivancos
name: A Espeso-García
name: LM Martínez-Aranda
name: GM Gea-García
name: FJ Orquín-Castrillón
name: A Carbonell-Baeza
name: JD Jiménez-García
name: D Velázquez-Díaz
name: C Cadenas-Sanchez
name: E Isidori
name: C Fossati
name: F Pigozzi
name: L Rum
name: C Norton
name: Tierney, Audrey
name: I Äbelkalns
name: A Klempere-Sipjagina
name: J Porozovs
name: H Hannola
name: N Niemisalo
name: L Hokka
name: D Jiménez-Pavón
name: R Vaquero-Cristóbal
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Li-censee MDPI, Basel, Switzerland. The revised European consensus defined sarcopenia as a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes including falls, fractures, physical disability and mortality. The aim of this study was to determine the prevalence of sarcopenia and analyse the influence of diet, physical activity (PA) and obesity index as risk factors of each criteria of sarcopenia. A total of 629 European middle-aged and older adults were enrolled in this cross-sectional study. Anthropometrics were assessed. Self-reported PA and adherence to the Mediterranean diet were evaluated with the Global Physical Activity Questionnaire (GPAQ) and Prevention with Mediterranean Diet questionnaire (PREDIMED), respectively. The functional assessment included handgrip strength, lower body muscle strength, gait speed and agility/dynamic balance. Of the participants, 4.84% to 7.33% showed probable sarcopenia. Sarcopenia was confirmed in 1.16% to 2.93% of participants. Severe sarcopenia was shown by 0.86% to 1.49% of participants. Male; age group ≤65 years; lower body mass index (BMI); high levels of vigorous PA; and the consumption of more than one portion per day of red meat, hamburgers, sausages or cold cuts and/or preferential consumption of rabbit, chicken or turkey instead of beef, pork, hamburgers or sausages (OR = 0.126–0.454; all p < 0.013) resulted as protective factors, and more time of sedentary time (OR = 1.608–2.368; p = 0.032–0.041) resulted as a risk factor for some criteria of sarcopenia. In conclusion, age, diet, PA, and obesity can affect the risk of having low muscle strength, low muscle mass or low functional performance, factors connected with sarcopenia.
Aortic thickness: A forgotten paradigm in risk stratification of aortic disease
Creators: name: Hardikar, Ashutosh
name: Harle, Robin
name: Marwick, Thomas
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Abstract Background This study aimed at risk-stratifying aortic dilatation using aortic wall thickness (AWT) and comparing methods of AWT assessment. Methods Demographic, epidemiological, and perioperative data on 72 consecutive aortic surgeries (age = 62 years[standard deviation (SD) = 12] years) performed by a single surgeon were collected from hospital database. Aortic thickness was measured on computed tomography scans, as well as intraoperatively in four quadrants, at the level of aortic sinuses, as well as midascending aorta, using calipers. Aortic wall stress was calculated using standard mathematical formulae. Results The ascending aorta was 48.2 (SD = 8) mm and the mean thickness at ascending aorta level was 1.9 (SD = 0.3) mm. There was congruence between imaging and intraoperative measurements of thickness, as well as between the radiologist and surgeon. Preoperatively, 16 patients had multiple imaging studies showing an average rate of growth of 1.2 mm per year without significant difference in thickness. The wider the aorta, the thinner was the lateral or convex wall. Aortic stenosis (p = 0.01), lateral to medial wall thickness ratio (p = 0.04), and history of hypertension (p = 0.00), all had protective effect on aortic root stress. The ascending aortic stress was directly affected by age (p = 0.03) and inversely related to lateral to medial wall thickness ratio (p = 0.03). Conclusion Aortic thickness can be measured preoperatively and easily confirmed intraoperatively. Risk stratification based on both aortic thickness and diameter (stress calculations) would better predict acute aortic events in dilated aortas and define aortic resection criteria more objectively.
Evaluating the Implementation of a Mental Health Referral Service “Connect to Wellbeing”: A Quality Improvement Approach
Creators: name: LA Onnis
name: I Kinchin
name: J Pryce
name: Ennals, Priscilla
name: J Petrucci
name: K Tsey
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Onnis, Kinchin, Pryce, Ennals, Petrucci and Tsey. There is increasing demand for mental health services to be accessible to diverse populations in flexible, yet, cost-effective ways. This article presents the findings from a study that evaluated the process of implementing Connect to Wellbeing (CTW), a new mental health intake, assessment and referral service in regional Australia, to determine how well it improved access to services, and to identify potential measures that could be used to evaluate value for money. The study used a hybrid study design to conduct a process evaluation to better understand: the process of implementing CTW; and the barriers and factors enabling implementation of CTW. In addition, to better understand how to measure the cost-effectiveness of such services, the hybrid study design included an assessment of potential outcome measures suitable for ascertaining both the effectiveness of CTW in client health outcomes, and conducting a value for money analysis. The process evaluation found evidence that by improving processes, and removing waitlists CTW had created an opportunity to broadened the scope and type of psychological services offered which improved accessibility. The assessment of potential outcome measures provided insight into suitable measures for future evaluation into service effectiveness, client health outcomes and value for money.
sj-docx-1-pbi-10.1177_10983007221137368 – Supplemental material for Improving Implementation Fidelity With Teacher-Directed Self-Monitoring Interventions: A Systematic Review
Creators: name: Scheibel, Gretchen
name: Chen, Pei-Yu
name: Zaeske, Lauren M.
name: Wills, Howard P.
name: Zimmerman, Kathleen N.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-1-pbi-10.1177_10983007221137368 for Improving Implementation Fidelity With Teacher-Directed Self-Monitoring Interventions: A Systematic Review by Gretchen Scheibel, Pei-Yu Chen, Lauren M. Zaeske, Howard P. Wills and Kathleen N. Zimmerman in Journal of Positive Behavior Interventions
Study on the microbial diversity of mangrove rhizosphere soil
Creators: name: 彭, 玲
Publisher: name: CNGB
Year: 2022
Subjects: Raw sequence reads
Metagenome
Environment

description: 中国红树林根际土壤微生物多样新研究，采集了不同地区的红树林根际微生物样品进行宏基因组测序分析。
Wayward Revolutions
Creators: name: Brooks, Andrew
Publisher: name: UNSW Sydney
Year: 2020

description: A review-essay of Saidiya Hartman's Wayward Lives, Beautiful Experiments that explores histories of fugitive desire, queer kinships, refusals and riots, sexual autonomy, and errantry – a history of possibilities enacted in spite of, and because of, the violent policing of Black life.
title: Diagnose: Hörschädigung
Creators: name: Dvorak, Michaela
Year: 2010

description: In der vorliegenden Arbeit wird dargestellt, wie Eltern auf die Diagnose „Hörschädigung“ ihres Kindes reagieren und welche Emotionen dadurch hervorgerufen werden. Weiters wird betrachtet, wie sich Eltern mit diesem „Kritischen Lebensereignis“ auseinandersetzen und wie die Frühförderin den Eltern bei dieser Auseinandersetzung unterstützen kann. Frühförderung ist ein Hilfsangebot für Kinder, die behindert oder von Behinderung bedroht sind. Sie versteht sich allerdings nicht nur als Leistung für das Kind, sondern auch als Angebot an die Eltern. Im Prozess der Frühförderung steht nicht nur die Behinderung, z.B. eine Hörschädigung, im Vordergrund, sondern das gesamte Lebensumfeld des Kindes. Einen wichtigen Teil dieses Umfeldes stellen die Eltern dar. Die Auseinandersetzung mit der Situation der Eltern nach der Diagnose und während des Frühförderprozesses bildet eine zentrale Grundlage für ein besseres Verständnis familiärer Lebenskontexte und Handlungsweisen und bietet die Chance, die Leitidee der Familienorientierung zunehmend konkreter und adressatenorientierter in die Praxis zu integrieren. Dazu gehört, zu verstehen, was eine Hörschädigung des Kindes für die Eltern bedeutet und welche Umstellungen für die Familie dadurch gerade im Alltag entstehen können. Ebenso wird dargestellt, was unter einem „Kritischen Lebensereignis“ zu verstehen ist und wie die Bewältigung einer Krise in der Literatur beschrieben wird. Eine differenzierte Betrachtung des Stresserlebens der Eltern und ihrer Bedürfnisse nach der Diagnose „Hörschädigung“ ebenso wie die Betrachtung ihrer Ressourcen bieten wichtige Informationen, wie das professionelle Hilfsangebot an die Eltern individuell gestaltet sein kann bzw. sollte. Mit Hilfe qualitativer Interviews von Eltern hörgeschädigter Kinder wird versucht, die Lebensrealität dieser Familien seit der Diagnose „Hörschädigung“ darzustellen und verstehen zu können. Dabei liegt der Fokus auf den Emotionen, die durch diese Diagnose hervorgerufen wurde und den Strategien und Ressourcen, die die Eltern zur Bewältigung dieses „Kritischen Lebensereignisses“ eingesetzt haben ebenso der Versuch darzustellen, wie die Frühförderin die Eltern bei diesem Bewältigungsprozess unterstützen kann. Als ein wichtiges Ergebnis dieser Untersuchung wurde festgestellt, dass die notwendigen Rahmenbedingungen eines möglichst frühen Erkennens einer Hörschädigung bei Babys noch nicht lückenlos vorhanden zu sein scheinen. Ein erst spätes Erkennen der Hörschädigung des Kindes kann von den Eltern als belastend erlebt werden, ebenso wie der Umgang der Professionellen mit den Eltern, z.B. wenn sich Eltern in ihren Befürchtungen nicht ernst genommen fühlen. Aus den Interviews wurde weiters ersichtlich, dass Eltern sehr unterschiedlich mit der Diagnose umgehen können und dementsprechend die Interventionen der Expertinnen individuell an die jeweilige Situation und Familie angepasst werden sollte.
O PAPEL DOS MOLUSCOS NAS HELMINTOSES
Creators: name: P. Calado, Maria Manuela
name: Machado Carlos Ferreira, Pedro Manuel
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
MEDICINA DO VIAJANTE: IMPORTÂNCIA E CONCEITOS
Creators: name: Marques, Nuno
name: Seixas, Jorge
name: Teodósio, Rosa
name: Atouguia, Jorge
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
Specimen Data Refinery - A novel approach to automating digitisation
Creators: name: Livermore, Laurence
name: Scott, Ben
name: Brack, Paul
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Specimen Data Refinery - A novel approach to automating digitisation by Laurence Livermore of Natural History Museum, London for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Short-wavelength-sensitive 2 (Sws2) visual photopigment models combined with atomistic molecular simulations to predict spectral peaks of absorbance
Creators: name: D Patel
name: JE Barnes
name: WIL Davies
name: DL Stenkamp
name: JS Patel
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Copyright: © 2020 Patel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For many species, vision is one of the most important sensory modalities for mediating essential tasks that include navigation, predation and foraging, predator avoidance, and numerous social behaviors. The vertebrate visual process begins when photons of the light interact with rod and cone photoreceptors that are present in the neural retina. Vertebrate visual photopigments are housed within these photoreceptor cells and are sensitive to a wide range of wavelengths that peak within the light spectrum, the latter of which is a function of the type of chromophore used and how it interacts with specific amino acid residues found within the opsin protein sequence. Minor differences in the amino acid sequences of the opsins are known to lead to large differences in the spectral peak of absorbance (i.e. the λmax value). In our prior studies, we developed a new approach that combined homology modeling and molecular dynamics simulations to gather structural information associated with chromophore conformation, then used it to generate statistical models for the accurate prediction of λmax values for photopigments derived from Rh1 and Rh2 amino acid sequences. In the present study, we test our novel approach to predict the λmax of phylogenetically distant Sws2 cone opsins. To build a model that can predict the λmax using our approach presented in our prior studies, we selected a spectrally-diverse set of 11 teleost Sws2 photopigments for which both amino acid sequence information and experimentally measured λmax values are known. The final first-order regression model, consisting of three terms associated with chromophore conformation, was sufficient to predict the λmax of Sws2 photopigments with high accuracy. This study further highlights the breadth of our approach in reliably predicting λmax values of Sws2 cone photopigments, evolutionary-more distant from template bovine RH1, and provided mechanistic insights into the role of known spectral tuning sites.
INFORMAÇÃO EM MEDICINA DAS VIAGENS: TER OU NÃO TER, EIS A QUESTÃO
Creators: name: Seixas, Jorge
name: Teodósio, Rosa
name: Atouguia, Jorge
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
Additional file 8 of Comparative transcriptome analysis reveals major genes, transcription factors and biosynthetic pathways associated with leaf senescence in rice under different nitrogen application
Creators: name: Zhang, Yafang
name: Wang, Ning
name: He, Chenggong
name: Gao, Zhiping
name: Chen, Guoxiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 8.