cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Surface modification of hydroxyapatite deposition onto titanium nanotubes for biomedical applications
Creators: name: Sarkhosh, Tooba
Publisher: name: University of Utah
Year: 2015
Subjects: Electrodeposition
Hydroxyapatite deposition
Titanium nanotubes

description: Ti and Ti alloys have been successfully used as orthopedic and dental implants. Various types of surface modification methods have been investigated to further improve the bioactivity of titanium. Growth of the hydroxyapatite onto nanotutbular titania was done by pulsed electrodeposition. The purpose of this study is to improve this surface by annealing the amorphous nanotubes to the anatase which is more efficient in nucleation and growth of apatite due to their crystal lattice match. Prior to the electrodeposition, the anodized nanotubes were heat-treated at 350 oC for 2 hours, and then they were electrodeposited in simulated body fluid. It is shown that heat treatment of nanotubular TiO2 could give us the better cohesion and bioactivity.
Sheep-work: food empires and pastoral resistance in the Intermountain West
Creators: name: Savage, Katy
Publisher: name: University of Utah
Year: 2012
Subjects: Animal ethics
Environmental justice
Pastoralism
Property
Sheep
Utah
Shepherds

description: The following thesis is an attempt to analyze current and historical patterns of violence through the lens of a species of domesticated animal--sheep. I begin by setting  down some founding provisions of the economic, political, and social systems within which sheep-work emerged, briefly tracking some of the historical roles sheep have played in the displacement, alienation and domination of other humans by others, from the time of sheep-domestication to the Mormon conquest of Utah. In this trajectory, sheep, embodying cultural ideals of „property? and „work,? show themselves repeatedly as able tools of land-theft and genocide. This analysis then opens the way to explore how these same beasts, and the same attempts to set down the meanings of 'property' and 'work,' have been necessary for resistance movements to these atrocities, which clarifies  the central importance of food-economies in political and racial conflict. This sets the stage for my second chapter, which explores the forces of oppression in modern sheepwork and its related industries, linking this oppression back to the historical devaluation of food-work. Finally, because I write this in the urgency of ecocide, the privatization of the last remaining peasant commons, and the disappearance of agricultural skills in a forced march to the cities, my last chapter focuses on the paths of resistance brought to light by this analysis of sheep-work. Those same concepts of 'property' and 'work' which have for millennia been tools in the abuse of both humans and ecosystems open themselves up for radical renegotiation by 'neo-pastoralists' and other food activists. This reconceptualizing work, carried out by those in active solidarity with both farmworkers and small farmers, holds out the promise of forming pragmatic, functioning communities where ecological care is born out of human egalitarianism and joined labor on the land, rather than through the urban-centered coerciveness of federal mandates which seek to 'preserve' Nature by clearing 'wilderness' of those who work there.
Brief an Gottfried Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1682

description: von Joh[ann] Wölffing
description: Mit rotem Siegel
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
AUTOMATIC FAULT NOTIFICATION ROCKET ENGINE HYDROGEN FUEL SYSTEM
Creators: name: Kulkarni, Siddharth
name: Singh, Prof. (Dr.) Reena
name: Chordiya, Prof. (Dr.) S. B.
Publisher: name: figshare
Year: 2022
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Aerospace Engineering
subject: 90102 Aerospace Materials
subject: 90103 Aerospace Structures
subject: 90202 Automotive Engineering Materials
subject: 90201 Automotive Combustion and Fuel Engineering (incl. Alternative/Renewable Fuels)
subject: FOS: Environmental engineering
subject: 91007 Manufacturing Robotics and Mechatronics (excl. Automotive Mechatronics)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Our Research “Automatic Fault Notification Rocket Engine Hydrogen Fuel System” is a ongoing shortcoming determination technique using a versatile hereditary calculation to upgrade a back engendering (BP) brain network is expected to accomplish continuous shortcoming discovery of a fluid rocket motor (LRE). In this paper, the creators utilize a versatile hereditary calculation to improve a BP brain organization, produce ongoing forecasts in regards to sensor information, contrast the extended worth with the genuine information gathered, and decide if the motor is breaking down utilizing an edge judgment component. The proposed shortcoming identification strategy is reproduced and checked utilizing information from a specific kind of fluid hydrogen and fluid oxygen rocket motor. The analysis results demonstrate the way that this strategy can actually analyze this fluid hydrogen and fluid oxygen rocket motor progressively. The proposed strategy has higher framework responsiveness and vigor contrasted and the outcomes got from a solitary BP brain network model and a BP brain network model enhanced by a customary hereditary calculation (GA), and the technique has designing application esteem.
Investigation of 5' messenger RNA stability determinants in lacZ
Creators: name: Wagner, Lori Ann
Publisher: name: University of Utah
Year: 2012
Subjects: Bacterial Genetics
Proteins

description: A series of initiation codon and Shine-Dalgarno (SD) sequence changes shows that the SD but not the initiation codon is necessary to maintain lacZ mRNA stability in Escherichia coli. A point mutation in the 4th codon (transcript base 55) of lacZ decreases mRNA stability and beta-galactosidase activity. This mutation also causes decreased beta-galactosidase activity in the background of altered SD and initiation codons. However, mRNA stability is not decreased in the presence of base 55-C and altered initiation codons. Downstream lacZ sequence up to codon 62 is also important for base 55-C's effect on gene expression. Therefore, ribosomal binding but not translation of the coding region is thought to be required for lacZ mRNA stability.
The (not so) secret governors of the internet: Morality policing and platform politics
Creators: name: McDowell, Zachary
name: Tiidenberg, Katrin
Publisher: name: University of Illinois at Chicago
Year: 2024
Subjects: classificationCode: 4701
subject: Communication and media studies
classificationCode: 47
subject: Language, communication and culture
classificationCode: 3605
subject: Screen and digital media
classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business

description: A growing body of academic work on internet governance focuses on the ‘deplatforming of sex’, or the removal and suppression of sexual expression from the internet. Often, this is linked to the 2018 passing of FOSTA/SESTA – much-criticized twin bills that make internet intermediaries liable for content that promotes or facilitates prostitution or sex trafficking. We suggest analyzing both internet governance and the deplatforming of sex in conjunction with long-term agendas of conservative lobbying groups. Specifically, we combine media historiography, policy analysis, and thematic and discourse analysis of the National Center on Sexual Exploitation’s (NCOSE, formerly Morality in Media) press releases and media texts to show how conservative moral entrepreneurs weaponize ideas of morality, obscenity, and harm in internet governance. We illustrate how NCOSE has, directly and indirectly, interfered in internet governance, first by lobbying for rigorous enforcement of obscenity laws and then for creating internet-specific obscenity laws (which we argue CDA, COPA, and FOSTA/SESTA all were for NCOSE). We show how NCOSE adjusted their rhetoric to first link pornography to addiction and pedophilia and later to trafficking and exploitation; how they took advantage of the #metoo momentum; mastered legal language, and incorporated an explicit anti-internet stance.
Brief an [Niklaus] Einert
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1682

description: von Joh[ann] Wölffing
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Growth and involution of lymphatic tissue and their relation to secretions of the adrenal cortex in CBA mice
Creators: name: Santisteban, George A.
Publisher: name: University of Utah
Year: 2012
Subjects: Endocrinology
Lymphatic Tissue

description: The primary aims of these experiments were:  (1) to determine the responses of various representative lymphatic organs to the process of aging in intact animals, (2) to determine the responses of the various lymphatic organs to adrenalectomy at successive ages.  From the data obtained it was hoped to secure information on the role of the adrenal glands in the control of growth and involution of each of the lymphatic organs.  Studies were made of the normal body growth and of the changes in absolute and relative weights of lymphatic and certain non-lymphatic organs from prepuberty, through puberty and sexual maturity to senility in male and female mice of the CBA strain.  These studies of the effect of adrenalectomy on the growth and involution of the lymphatic organs have shown that:  1. The secretions of the adrenal glands, probably the cortex, restrain growth and enhance involution.  2. The influence of the adrenal glands is greatest in the youngest animals and in the oldest animals, indicating greater secretory activities of these glands during those periods of life.  3. The lack of the secretions of the adrenal glands, however, does not permit unlimited growth.  The increased growth following adrenalectomy is greatest after a five day period.  4. The different lymphatic organs respond differently to adrenalectomy, although all except the thymus following the same general pattern.  The effects on the thymus are, in general, the reverse of those of other organs.  5. Each lymph organ responds differently at different ages.  In all but the thymus the response tends to be greatest in the young animals and senile animals, and least in the sexually mature animals.  The response of the thymus tends to be greatest in the sexually mature animals.  6. There exist sex differences in the response of all lymphatic organs to adrenalectomy at all ages.  There are small and more quantitative in nature and are most evident in young animals.  These sex differences indicate a role played by sex hormones in controlling growth and involution of lymphatic tissue.  7. The weights of the adrenal glands were greater in the females at all ages and this may be correlated with the greater relative weights of lymphatic organs of the females.  8. These variations among glands and in age, sex, and period following adrenalectomy must be recognized in comparing data obtained from the literature and in future experiments.
Brief an Gottfried Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1683

description: von Joh[ann] Wölffing
description: Mit rotem Siegel
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
REDEMOS Dissemination, Exploitation and Communication Strategy
Creators: name: Schumacher, Tobias
Publisher: name: Zenodo
Year: 2024
Subjects: Dissemination
Exploitation
Communication

description: This stratgey at provides a focused approach towards the key target audiences and the best strategies to engage and inform stakeholders, ensuring maximum awareness of REDEMOS activities. In the deliverable’s subsections, a detailed definition of the meaning of dissemination, exploitation and communication in the context of REDEMOS is provided, mainly with a view to enable the reader to gain a clear understanding of the differences, complementarities and overlaps between these concepts.
Brief an [Gottfried] Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1680

description: von J[ohann] W[ölffing]
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
The transcriptional response of Arcobacter butzleri to cold shock
Creators: name: Zhang, Xiaochen
name: Su, Yulan
name: Alter, Thomas
name: Gölz, Greta
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: A. butzleri
subject: cold adaptation
subject: cold shockrelated genes
subject: temporal transcriptional expression
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::632 Schäden, Krankheiten, Schädlinge an Pflanzen

description: Arcobacter (A.) butzleri is an emerging zoonotic pathogen associated with gastrointestinal diseases, such as abdominal cramps and diarrhea, and is widely detected in animals, showing a high prevalence in poultry and seafood. The survival and adaptation of A. butzleri to cold temperatures remains poorly studied, although it might be of interest for food safety considerations. To address this, growth patterns of eight A. butzleri isolates were determined at 8 °C for 28 days. A. butzleri isolates showed strain‐dependent behavior: six isolates were unculturable after day 18, one exhibited declining but detectable cell counts until day 28 and one grew to the stationary phase level. Out of 13 A. butzleri cold shock‐related genes homologous to Escherichia coli, 10 were up‐regulated in response to a temperature downshift to 8 °C, as demonstrated by reverse transcription‐quantitative PCR. Additionally, we compared these data with the cold‐shock response in E. coli. Overall, we provide a deeper insight into the environmental adaptation capacities of A. butzleri, which we find shares similarities with the E. coli cold‐shock response.
Brief an Fratres in Christo
Creators: name: Wegelin, Georg
Publisher: name: [s.n.]
Year: 1661

description: von [Johann] Georg Wegelin
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire März 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
A biocompatible reverse thermoresponsive polymer for ocular drug delivery
Creators: name: Balachandra, Asitha
name: Chan, Elsa C.
name: Paul, Joseph P.
name: Ng, Sze
name: Chrysostomou, Vicki
name: Ngo, Steven
name: Mayadunne, Roshan
name: van Wijngaarden, Peter
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology

description: Age-related macular degeneration (AMD) is a leading cause of vision loss, the treatment of which may require monthly intravitreal injections. This is a burden on patients and health services, and new delivery modalities that reduce injection frequency are required. To that end, we investigated the suitability of a novel reverse thermoresponsive polymer (RTP) as an ocular drug-delivery vehicle. In this work, we detail the structure and synthesis of a novel RTP, and determine drug release curves for two drugs commonly used in the treatment of AMD, bevacizumab and aflibercept. Biocompatibility of the RTP was assessed in vitro in human and rat cell lines and in vivo following intravitreal injection in rats. Bevacizumab demonstrated a more appropriate release profile than aflibercept, with 67% released within 14 days and 78% released in total over a 183-day period. No toxic effects of RTP were seen in human or rat cells in up to 14 days of co-culture with RTP. Following intravitreal injection, intraocular pressure was unaffected by the presence of RTP and no changes in retinal function or structure were observed at 1 week or 1 month post-injection. RTP injection did not cause inflammation, gliosis or apoptosis in the retina. This work demonstrates the potential suitability of the novel RTP as a sustained-release vehicle for ocular drug delivery for anti-neovascular therapies. Optimization of polymer chemistry for optimal drug loading and release is needed.
Energy efficient and reliable communication in IEEE 802 15.6 IR UWB WBAN
Creators: name: ARAVIND M T
Publisher: name: figshare
Year: 2020
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents an exhaustive study on the use of one-relay and two-relay cooperative communication schemes and 2-hop communication scheme for improving the energy efficiency and reliability of ultra-wideband based wireless body area networks (UWB WBANs). Various investigations have been performed to study the impact of the parameters like packet size, hop distance, transmit power and channel error rate on the energy efficiency and reliability. An optimal packet size is obtained for the maximization of energy efficiency for both on-body communication and in-body communication. The analytical and simulation results show enhanced reliability with cooperative communication than direct communication and 2-hop communication, for all values of source to destination distances. The results also depict a threshold behaviour for energy efficiency which separates the hoplength for direct transmission from the hoplength where cooperation and 2-hop communication will be useful. The simulation results reveal that if the channel conditions are poor, when the source to destination distance is larger than the threshold value, 2-hop communication gives higher energy efficiency compared with direct and cooperative communications
Sonnenfleckenzeichnung Nr. 23476.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23493.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Polydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer
Creators: name: Banstola, Asmita
name: Pham, Tung Thanh
name: Jeong, Jee-Heon
name: Yook, Simmyung
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Chemotherapeutic drugs often used as a first-line treatment of pancreatic cancer (PC) exhibit challenges due to resistance development, lack of selectivity, and tumor heterogeneity. Currently, combination chemo-photothermal therapy is known to enhance the therapeutic efficacy of chemotherapeutic drugs in PC. In this study, we develop adherent gold nanoparticles (GNPs) and paclitaxel (PTX)-loaded PLGA microspheres for the treatment of PC. Polydopamine (pD) was used as a linker to adhere GNPs to the surface of PLGA-Ms and characterized using TEM. Short-term cytotoxicity of GNPs-pD-PTX-PLGA-Ms with or without NIR treatment was evaluated using CCK-8 assays. ROS and western blot assay were performed to determine the intensity of ROS following the treatment of GNPs-pD-PTX-PLGA-Ms with or without NIR in Panc-1 cell line. Successful adhesion of GNPs on the microspheres was confirmed by TEM. CCK-8 assay revealed that GNPs-pD-PTX-PLGA-Ms with NIR showed three-fold higher cytotoxicity, compared to the group without NIR. Furthermore, ROS and western blot assay suggest that GNPs-pD-PTX-PLGA-Ms with NIR showed more ROS generation, followed by downregulation of the expression levels of antioxidant enzyme (SOD2 and CATALASE). These results suggest that the GNPs-pD-PTX-PLGA-Ms in combination with NIR irradiation can provide a synergistic chemo-photothermal therapy for the treatment of PC.
Sonnenfleckenzeichnung Nr. 23479.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23397.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23530.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.12.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity
Creators: name: Plenagl, Nikola
name: Duse, Lili
name: Seitz, Benjamin Sebastian
name: Goergen, Nathalie
name: Pinnapireddy, Shashank Reddy
name: Jedelska, Jarmila
name: Brüßler, Jana
name: Bakowsky, Udo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, the administration to biological systems or patients requires the formulation in drug carriers enabling sufficient bioavailability. Therefore, free hypericin was encapsulated by the thin film hydration method or a hypericin-hydroxypropyl-β-cyclodextrin inclusion complex (Hyp-HPβCD) was incorporated by dehydration-rehydration vesicle method in either conventional or ultra-stable tetraether lipid (TEL) liposomes. The hydrodynamic diameter of the prepared nanoformulations ranged between 127 and 212 nm. These results were confirmed by atomic force microscopy. All liposomes showed a good stability under physiological conditions. TEL liposomes which tend to build more rigid bilayers, generate higher encapsulation efficiencies than their conventional counterparts. Furthermore, the suitability for intravenous application was confirmed by hemocompatibility studies resulting in a hemolytic potential less than 20% and a coagulation time less than 50 sec. The uptake of liposomal hypericin into human ovarian carcinoma cells (SK-OV-3) was confirmed using confocal microscopy and further characterized by pathway studies. It was demonstrated that the lipid composition and intraliposomal hypericin localization influenced the anti-vascular effect in the chorioallantoic membrane (CAM). While hypericin TEL liposomes exhibit substantial destruction of the microvasculature drug-in-cyclodextrin TEL liposomes showed no effect. Nevertheless, both formulations yielded severe photocytotoxicity in SK-OV-3 cells in a therapeutic dosage range. Conclusively, hypericin TEL liposomes would be perfectly suited for anti-vascular targeting while Hyp-HPβCD TEL liposomes could deliver the photosensitizer to the tumor site in a more protected manner.
Sonnenfleckenzeichnung Nr. 23520.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.12.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Wow, that bitch is crazy!: exploring gendered performances in leisure spaces surrounding reality television
Creators: name: Spencer, Callie Cross
Publisher: name: University of Utah
Year: 2015
Subjects: Cultural studies
Duoethnography
Gender
Performance studies
Poststructuralism
The Bachelor

description: In Reality Bites Back, Jennifer L. Pozner states, "Women are bitches. Women are stupid. Women are incompetent at work and failures at home. Women are gold diggers. How do we know? Because reality TV tells us so." Not only does reality TV shape what we think about the "way things are," it also shapes how we think about and perform our own subjectivities, "who we are" as gendered, sexed, raced, classed humans. If the messages sent by reality TV are that women are incompetent, stupid, gold-digging bitches, what are women doing with those messages? Are we incorporating such messages, and writing them on our bodies? Repurposing them? Reproducing them? Actively and strongly resisting them? In other words, what is the work (on subjectivity production) of watching reality TV (watching other women being watched)? The purpose of this dissertation was to take up that question by exploring the performative experiences of three women watching the 17th season of ABC's The Bachelor. Using duoethnography, we explored how we challenged, (re)produced, assigned, and constructed gendered subjectivities both for ourselves and for each other through our performances within leisure spaces surrounding The Bachelor. In three layers of data-generative surveillance, we 1) videotaped ourselves watching the show; 2) publicly reflected about our experiences of watching the show in a blog (www.blogaboutthebachelor.com); and, 3) spent a weekend together watching the videotape of ourselves watching the show (a hyper-reflexive experience). Within the blog, we provided a space for women to react to, critique, support, or decenter messages sent by the show and one another. As such, the blog enacted a political project in order to decenter norms of practice offering more possibilities for gendered performance. In addition to this public political project, the results of our study as presented in five articles within this dissertation provide a methodological contribution to the body of knowledge by exploring what it means to do "empowering" "collaborative" feminist research. The ways in which we performed gendered subjectivities in reaction to messages sent by The Bachelor were inextricably entangled with the ways in which we performed gendered subjectivities as collaborative researchers.
Sonnenfleckenzeichnung Nr. 23511.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.11.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Mechanism of proteasome stimulation by 11S activators
Creators: name: F©rster, Andreas
Publisher: name: University of Utah
Year: 2012
Subjects: Crystallography
Molecular Biology

description: The 20S proteasome is a complex machine that is responsible for the bulk of nonlysosomal intracellular proteolysis in eukaryotes. Its catalytic sites are sequestered in the interior of the cylindrical structure, and activity is tightly regulated at the level of substrate presentation and access. Purified proteasomes are inactive in vitro, but through association with activating complexes they gain the capacity to degrade substrate proteins and peptides. The crystal structure of the yeast proteasome-PA26 complex showed that the activator PA26 functions by opening an axial pore into the proteasome, apparently by introducing disorder in the normally closed pore region. In this dissertation, I address the questions of how the proteasome and activator interact, how 11S activators stimulate proteasomes from multiple diverse species, how the open pore conformation is stabilized, and the extent to which results from one particular type of activator or proteasome can be generalized.  To this end, the structure of the yeast proteasome-PA26 structure was reanalyzed, and a cluster of four conserved residues was identified that stabilize an ordered sevenfold symmetric open gate conformation. I performed protein degradation assays with a different activator, PAN, and a number of archaeal Thermoplasma acidophilum proteasome mutants and showed that the four residues that stabilize the open gate in yeast are also important for PAN-dependent proteolysis by the archaeal proteasome. I also demonstrated a direct interaction between PA26 and the T. acidophilum proteasome and determined high resolution crystal structures of three proteasome-activator complexes. The wildtype complex revealed the presence of the open conformation in archaeal proteasomes. In contrast, the absence of the open conformation in two structures of mutant archaeal proteasomes deficient in the stabilizing residues bound to PA26 reinforces the importance of the stabilizing cluster and suggests that all proteasomes are activated through formation of the same open gate conformation. Finally, since PA26 interacts with proteasome through its C termini, I performed protein degradation assays with proteasomes mutated in their binding pockets and with C-terminally truncated PAN. The results of these experiments suggest that PAN, and by homology the eukaryotic activator PA700, might interact with proteasomes similar to PA26.
Sonnenfleckenzeichnung Nr. 23497.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23435.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa
Creators: name: Platania, Chiara Bianca Maria
name: Dei, Michele
name: Cianciolo, Simona
name: Fidilio, Annamaria
name: Lazzara, Francesca
name: Paroni, Rita
name: Pignatello, Rosario
name: Strettoi, Enrica
name: Ghidoni, Riccardo
name: Drago, Filippo
name: Bucolo, Claudio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Myriocin is an antibiotic derived from Mycelia sterilia, and is a potent inhibitor of serine palmitoyltransferase, the enzyme involved in the first step of sphingosine synthesis. Myriocin, inhibiting ceramide synthesis, has a great potential for treatment of diseases characterized by high ceramide levels in affected tissues, such as retinitis pigmentosa (RP). Drug delivery to the retina is a challenging task, which is generally by-passed through intravitreal injection, that represents a risky invasive procedure. We, therefore, developed and characterized an ophthalmic topical nanotechnological formulation based on a nanostructured lipid carrier (NLC) and containing myriocin. The ocular distribution of myriocin in the back of the eye was assessed both in rabbits and mice using LC-MS/MS. Moreover, rabbit retinal sphingolipid and ceramides levels, after myriocin-NLC (Myr-NLC) eye drops treatment, were assessed. The results demonstrated that Myr-NLC formulation is well tolerated and provided effective levels of myriocin in the back of the eye both in rabbits and mice. We found that Myr-NLC eye drops treatment was able to significantly decrease retinal sphingolipid levels. In conclusion, these data suggest that the Myr-NLC ophthalmic formulation is suitable for pharmaceutical development and warrants further clinical evaluation of this eye drops for the treatment of RP.
A biocompatible reverse thermoresponsive polymer for ocular drug delivery
Creators: name: Balachandra, Asitha
name: C. Chan, Elsa
name: Paul, Joseph P.
name: Ng, Sze
name: Chrysostomou, Vicki
name: Ngo, Steven
name: Mayadunne, Roshan
name: van Wijngaarden, Peter
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology

description: Age-related macular degeneration (AMD) is a leading cause of vision loss, the treatment of which may require monthly intravitreal injections. This is a burden on patients and health services, and new delivery modalities that reduce injection frequency are required. To that end, we investigated the suitability of a novel reverse thermoresponsive polymer (RTP) as an ocular drug-delivery vehicle. In this work, we detail the structure and synthesis of a novel RTP, and determine drug release curves for two drugs commonly used in the treatment of AMD, bevacizumab and aflibercept. Biocompatibility of the RTP was assessed in vitro in human and rat cell lines and in vivo following intravitreal injection in rats. Bevacizumab demonstrated a more appropriate release profile than aflibercept, with 67% released within 14 days and 78% released in total over a 183-day period. No toxic effects of RTP were seen in human or rat cells in up to 14 days of co-culture with RTP. Following intravitreal injection, intraocular pressure was unaffected by the presence of RTP and no changes in retinal function or structure were observed at 1 week or 1 month post-injection. RTP injection did not cause inflammation, gliosis or apoptosis in the retina. This work demonstrates the potential suitability of the novel RTP as a sustained-release vehicle for ocular drug delivery for anti-neovascular therapies. Optimization of polymer chemistry for optimal drug loading and release is needed.
Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity
Creators: name: Plenagl, Nikola
name: Duse, Lili
name: Seitz, Benjamin Sebastian
name: Goergen, Nathalie
name: Pinnapireddy, Shashank Reddy
name: Jedelska, Jarmila
name: Brüßler, Jana
name: Bakowsky, Udo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, the administration to biological systems or patients requires the formulation in drug carriers enabling sufficient bioavailability. Therefore, free hypericin was encapsulated by the thin film hydration method or a hypericin-hydroxypropyl-β-cyclodextrin inclusion complex (Hyp-HPβCD) was incorporated by dehydration-rehydration vesicle method in either conventional or ultra-stable tetraether lipid (TEL) liposomes. The hydrodynamic diameter of the prepared nanoformulations ranged between 127 and 212 nm. These results were confirmed by atomic force microscopy. All liposomes showed a good stability under physiological conditions. TEL liposomes which tend to build more rigid bilayers, generate higher encapsulation efficiencies than their conventional counterparts. Furthermore, the suitability for intravenous application was confirmed by hemocompatibility studies resulting in a hemolytic potential less than 20% and a coagulation time less than 50 sec. The uptake of liposomal hypericin into human ovarian carcinoma cells (SK-OV-3) was confirmed using confocal microscopy and further characterized by pathway studies. It was demonstrated that the lipid composition and intraliposomal hypericin localization influenced the anti-vascular effect in the chorioallantoic membrane (CAM). While hypericin TEL liposomes exhibit substantial destruction of the microvasculature drug-in-cyclodextrin TEL liposomes showed no effect. Nevertheless, both formulations yielded severe photocytotoxicity in SK-OV-3 cells in a therapeutic dosage range. Conclusively, hypericin TEL liposomes would be perfectly suited for anti-vascular targeting while Hyp-HPβCD TEL liposomes could deliver the photosensitizer to the tumor site in a more protected manner.
Sonnenfleckenzeichnung Nr. 23464.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23444.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The Open Science MOOC
Creators: name: Candian, Alessandra
name: Walma, Lisanne
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
OLS-5

description: Presentation of our Graduation Project "Building a community around the TU Delft Open Science MOOC" for the 5th cohort (Cohort Hope) of the Open Life Science Program.
Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery
Creators: name: Zhan, Wenbo
name: Rodriguez y Baena, Ferdinando
name: Dini, Daniele
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified

description: Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Here, the responses of six different drugs to the tissue anisotropy are examined through a parametric study performed using a multiphysics model, which considers interstitial fluid flow, tissue deformation and interlinked drug transport processes in CED. The delivery outcomes are evaluated in terms of the penetration depth and delivery volume for effective therapy. Simulation results demonstrate that the effective penetration depth in a given direction can be improved with the increase of the corresponding component of anisotropic characteristics. The anisotropic tissue permeability could only reshape the drug distribution in space but has limited contribution to the total effective delivery volume. On the other hand, drugs respond in different ways to the anisotropic diffusivity. The large delivery volumes of fluorouracil, carmustine, cisplatin and doxorubicin could be achieved in relatively isotropic tissue, while paclitaxel and methotrexate are able to cover enlarged regions into anisotropic tissues. Results obtained from this study serve as a guide for the design of CED treatments.