Common variants in breast cancer risk loci predispose to distinct tumor subtypes.
Creators: name: Ahearn, Thomas U
name: Zhang, Haoyu
name: Michailidou, Kyriaki
name: Milne, Roger L
name: Bolla, Manjeet K
name: Dennis, Joe
name: Dunning, Alison M
name: Lush, Michael
name: Wang, Qin
name: Andrulis, Irene L
name: Anton-Culver, Hoda
name: Arndt, Volker
name: Aronson, Kristan J
name: Auer, Paul L
name: Augustinsson, Annelie
name: Baten, Adinda
name: Becher, Heiko
name: Behrens, Sabine
name: Benitez, Javier
name: Bermisheva, Marina
name: Blomqvist, Carl
name: Bojesen, Stig E
name: Bonanni, Bernardo
name: Børresen-Dale, Anne-Lise
name: Brauch, Hiltrud
name: Brenner, Hermann
name: Brooks-Wilson, Angela
name: Brüning, Thomas
name: Burwinkel, Barbara
name: Buys, Saundra S
name: Canzian, Federico
name: Castelao, Jose E
name: Chang-Claude, Jenny
name: Chanock, Stephen J
name: Chenevix-Trench, Georgia
name: Clarke, Christine L
name: NBCS Collaborators
name: Collée, J Margriet
name: Cox, Angela
name: Cross, Simon S
name: Czene, Kamila
name: Daly, Mary B
name: Devilee, Peter
name: Dörk, Thilo
name: Dwek, Miriam
name: Eccles, Diana M
name: Evans, D Gareth
name: Fasching, Peter A
name: Figueroa, Jonine
name: Floris, Giuseppe
name: Gago-Dominguez, Manuela
name: Gapstur, Susan M
name: García-Sáenz, José A
name: Gaudet, Mia M
name: Giles, Graham G
name: Goldberg, Mark S
name: González-Neira, Anna
name: Alnæs, Grethe I Grenaker
name: Grip, Mervi
name: Guénel, Pascal
name: Haiman, Christopher A
name: Hall, Per
name: Hamann, Ute
name: Harkness, Elaine F
name: Heemskerk-Gerritsen, Bernadette AM
name: Holleczek, Bernd
name: Hollestelle, Antoinette
name: Hooning, Maartje J
name: Hoover, Robert N
name: Hopper, John L
name: Howell, Anthony
name: ABCTB Investigators
name: KConFab/AOCS Investigators
name: Jakimovska, Milena
name: Jakubowska, Anna
name: John, Esther M
name: Jones, Michael E
name: Jung, Audrey
name: Kaaks, Rudolf
name: Kauppila, Saila
name: Keeman, Renske
name: Khusnutdinova, Elza
name: Kitahara, Cari M
name: Ko, Yon-Dschun
name: Koutros, Stella
name: Kristensen, Vessela N
name: Krüger, Ute
name: Kubelka-Sabit, Katerina
name: Kurian, Allison W
name: Kyriacou, Kyriacos
name: Lambrechts, Diether
name: Lee, Derrick G
name: Lindblom, Annika
name: Linet, Martha
name: Lissowska, Jolanta
name: Llaneza, Ana
name: Lo, Wing-Yee
name: MacInnis, Robert J
name: Mannermaa, Arto
name: Manoochehri, Mehdi
name: Margolin, Sara
name: Martinez, Maria Elena
name: McLean, Catriona
name: Meindl, Alfons
name: Menon, Usha
name: Nevanlinna, Heli
name: Newman, William G
name: Nodora, Jesse
name: Offit, Kenneth
name: Olsson, Håkan
name: Orr, Nick
name: Park-Simon, Tjoung-Won
name: Patel, Alpa V
name: Peto, Julian
name: Pita, Guillermo
name: Plaseska-Karanfilska, Dijana
name: Prentice, Ross
name: Punie, Kevin
name: Pylkäs, Katri
name: Radice, Paolo
name: Rennert, Gad
name: Romero, Atocha
name: Rüdiger, Thomas
name: Saloustros, Emmanouil
name: Sampson, Sarah
name: Sandler, Dale P
name: Sawyer, Elinor J
name: Schmutzler, Rita K
name: Schoemaker, Minouk J
name: Schöttker, Ben
name: Sherman, Mark E
name: Shu, Xiao-Ou
name: Smichkoska, Snezhana
name: Southey, Melissa C
name: Spinelli, John J
name: Swerdlow, Anthony J
name: Tamimi, Rulla M
name: Tapper, William J
name: Taylor, Jack A
name: Teras, Lauren R
name: Terry, Mary Beth
name: Torres, Diana
name: Troester, Melissa A
name: Vachon, Celine M
name: Van Deurzen, Carolien HM
name: Van Veen, Elke M
name: Wagner, Philippe
name: Weinberg, Clarice R
name: Wendt, Camilla
name: Wesseling, Jelle
name: Winqvist, Robert
name: Wolk, Alicja
name: Yang, Xiaohong R
name: Zheng, Wei
name: Couch, Fergus J
name: Simard, Jacques
name: Kraft, Peter
name: Easton, Douglas
name: Pharoah, Paul
name: Schmidt, Marjanka K
name: García-Closas, Montserrat
name: Chatterjee, Nilanjan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research Article
Breast cancer
Etiologic heterogeneity
Genetic predisposition
Common breast cancer susceptibility variants

description: Funder: Genome Canada and the Canadian Institutes of Health Research
description: Funder: Génome Québec; doi: http://dx.doi.org/10.13039/100013062
description: Funder: Foundation for the National Institutes of Health; doi: http://dx.doi.org/10.13039/100000009
description: Funder: Center for Inherited Disease Research
description: Funder: Cancer Research UK
description: Funder: Odense University Hospital Research Foundation
description: Funder: National R&amp;D Program for Cancer Control–Ministry of Health and Welfare
description: Funder: Italian Association for Cancer Research
description: Funder: Carol M. Baldwin Breast Cancer Research Fund; doi: http://dx.doi.org/10.13039/100002645
description: Funder: National Health and Medical Research Council
description: Funder: Deutsche Kinderkrebsstiftung; doi: http://dx.doi.org/10.13039/501100007311
description: Funder: European Union
description: Funder: National Institutes of Health; doi: http://dx.doi.org/10.13039/100000002
description: Funder: National Cancer Institute
description: Funder: Canadian Institutes of Health Research; doi: http://dx.doi.org/10.13039/501100000024
description: Funder: Susan G. Komen for the Cure, Komen Wyoming Affiliate; doi: http://dx.doi.org/10.13039/100005987
description: Funder: Ovarian Cancer Research Fund; doi: http://dx.doi.org/10.13039/100001282
description: Funder: National Cancer Institute (NCI)
description: BACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. METHODS: Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes. RESULTS: Eighty-five of 173 variants were associated with at least one tumor feature (false discovery rate