cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bounds for the asymptotic order parameter of the stochastic Kuramoto model
Creators: name: Mező, István
name: Baricz, Árpád
Publisher: name: arXiv
Year: 2016
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 39B62, 33C10

description: Turán type inequalities for modified Bessel functions of the first kind are used to deduce some sharp lower and upper bounds for the asymptotic order parameter of the stochastic Kuramoto model. Moreover, approximation from the Lagrange inversion theorem and a rational approximation are given for the asymptotic order parameter.
description: 10 pages, 3 figures
Additional Information on Heavy Quark Parameters from Charged Lepton Forward-Backward Asymmetry
Creators: name: Turczyk, Sascha
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The determination of $|V_{cb}|$ using inclusive and exclusive (semi-)leptonic decays exhibits a long-standing tension of varying ${\cal O}(3 σ)$ significance. For the inclusive determination the decay rate is expanded in $1/m_b$ using heavy quark expansion, and from moments of physical observables the higher order heavy quark parameters are extracted from experimental data in order to assess $|V_{cb}|$ from the normalisation. The drawbacks are high correlations both theoretically as well as experimentally among these observables. We will scrutinise the inclusive determination in order to add a new and less correlated observable. This observable is related to the decay angle of the charged lepton and can help to constrain the important heavy quark parameters in a new way. It may validate the current seemingly stable extraction of $|V_{cb}|$ from inclusive decays or hints to possible issues, and even may be sensitive to New Physics operators.
Toward more localized local algorithms: removing assumptions concerning global knowledge
Creators: name: Korman, Amos
name: Sereni, Jean-Sébastien
name: Viennot, Laurent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: Numerous sophisticated local algorithm were suggested in the literature for various fundamental problems. Notable examples are the MIS and $(Δ+1)$-coloring algorithms by Barenboim and Elkin [6], by Kuhn [22], and by Panconesi and Srinivasan [34], as well as the $O(Δ2)$-coloring algorithm by Linial [28]. Unfortunately, most known local algorithms (including, in particular, the aforementioned algorithms) are non-uniform, that is, local algorithms generally use good estimations of one or more global parameters of the network, e.g., the maximum degree $Δ$ or the number of nodes n. This paper provides a method for transforming a non-uniform local algorithm into a uniform one. Furthermore , the resulting algorithm enjoys the same asymp-totic running time as the original non-uniform algorithm. Our method applies to a wide family of both deterministic and randomized algorithms. Specifically, it applies to almost all state of the art non-uniform algorithms for MIS and Maximal Matching, as well as to many results concerning the coloring problem. (In particular, it applies to all aforementioned algorithms.) To obtain our transformations we introduce a new distributed tool called pruning algorithms, which we believe may be of independent interest.
Introduction of Smart Technologies in PV Production Equipment
Creators: name: Zimmer, M.
name: Mohr, L.
name: Broese, B.
name: Krick, T.
name: Rentsch, J.
name: Mandlmeier, B.
name: Papp, L.
name: Menschick, M.
name: Kogler, R.
name: Strauch, A.
name: Will, T.
name: Meckelin, V.
name: Mutz, P.
name: Korner, D.
name: Kremer, M.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Manufacturing & Production of Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 298-301
description: Increasing digitalization is a consequent development of the automation of PV manufacturing
processes. A central concept in the digitalization of production processes is the digital twin of physical assets. This
digital twin represents the asset in its properties and behavior. In this paper, it is shown, that a digital twin of a wet
chemical process tool is suitable to improve processes and save production costs. Computational flow dynamics
simulations were used to investigate and improve the flow properties in wet chemical process baths. Furthermore, a
coupling with a chemical reaction simulation can predict the rounding process of random pyramids in ozone based
cleaning baths. As a third use case, a concept for a predictive maintenance system is shown, which could reduce the
unscheduled down time of the tool and therefore save maintenance costs.
Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
Creators: name: Rossi, Niccolo’
name: Aliyev, Elbay
name: Visconti, Alessia
name: Akil, Ammira S. A.
name: Syed, Najeeb
name: Aamer, Waleed
name: Padmajeya, Sujitha S.
name: Falchi, Mario
name: Fakhro, Khalid A.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P = 7.50 × 10−3) and show that Qataris of Arab descent have significantly lower CN at AMY1 (P = 1.32 × 10−10) as well as less favorable adiposity and metabolic profiles (P < 1.34 × 10−8) than Qataris with Persian ancestry. Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P < 4.60 × 10−3) but not in Persians. Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs (P = 4.29 × 10−5), with AMY1 CN showing negative association with dietary self-restraint (P = 3.22 × 10−3). This study reports an association between amylase gene CN and adiposity traits in a large Middle Eastern population. Importantly, we leverage rich biobank data to demonstrate that the strength of this association varies with ethnicity, and may be influenced by population-specific behaviors that also contribute to adiposity traits.Other Information Published in: npj Genomic Medicine
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41525-021-00170-3
Optical Investigation of High-Efficiency Silicon-Based Solar Cells with Multi-Scale Interface Textures Enabled by Coupled Modelling Approach
Creators: name: Lipovsek, B.
name: Lokar, Z.
name: Razzaq, A.
name: Depauw, V.
name: Gordon, I.
name: Poortmans, J.
name: Krc, J.
name: Topic, M.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Characterisation & Simulation Methods for Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 244-248
description: In high-efficiency bifacial heterojunction silicon solar cells, microscale and nanoscale textures are
utilized at different interfaces within the device structures to further improve their performance. We demonstrate the
applicability of the coupled modelling approach (CMA) for accurate numerical analysis and optimization of such
complex devices. We investigate the influence of surface texturization of the silicon wafer as well as light
management properties of the encapsulation. The results show that texturization of the silicon surface alone boosts
the short-circuit current density by 23 % with respect to a non-textured cell, however little differences between
nanoscale or microscale textures are observed in this case. By introducing microtextured light management foil at the
front and rear surface of the encapsulated solar cell, significant additional current gains of over 5 % can be achieved.
Inline Characterization of Diamond Wire Sawn Multicrystalline Silicon Wafers
Creators: name: Haunschild, J.
name: Bergmann, N.
name: Hammer, T.
name: Krieg, K.
name: Kaden, T.
name: Anspach, O.
name: Schremmer, H.
name: Rein, S.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Characterisation & Simulation Methods for Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 222-228
description: While for monocrystalline silicon ingot slicing diamond wire sawing processes are widely used, the general approach for slicing multicrystalline bricks has been based on slurry wire processes. Driven by a strong decrease in wafer prices recently, wafer manufacturers of multicrystalline materials switched rather quickly to the diamond-cut process, although several severe technological challenges were to be faced. Unfortunately, sawing is more difficult and an adaptation of solar cell production is essential for texturing processes considering diamond-cut wafer surface morphology. Also characterization methodologies must be adapted to these new material properties. Especially saw mark inspection and thickness topology measurements are key aspects of developments. General imaging methods also need to be evaluated for defect detection and wafer rating purpose. In this paper, an overview of inline characterization methods and their applicability on diamond-cut wafers will be given. Five out of eight methods need hardware or software adjustments to work on diamond-cut wafers. Special attention is paid to the photoluminescence analysis which allows a forecast of solar cell parameters if the relevant defect features are correctly extracted from the images. Due to the increased optical artifacts, this is not a trivial task.
Goodness-of-fit analysis of the Cosmicflows-2 database of velocities
Creators: name: Hoffman, Yehuda
name: Nusser, Adi
name: Courtois, Helene M.
name: Tully, R. Brent
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The goodness-of-fit (GoF) of the Cosmicflows-2 (CF2) database of peculiar velocities with the LCDM standard model of cosmology is presented. Standard application of the Chi^2 statistics of the full database, of its 4,838 data points, is hampered by the small scale nonlinear dynamics which is not accounted for by the (linear regime) velocity power spectrum. The bulk velocity constitutes a highly compressed representation of the data which filters out the small scales non-linear modes. Hence the statistics of the bulk flow provides an efficient tool for assessing the GoF of the data given a model. The particular approach introduced here is to use the (spherical top-hat window) bulk velocity extracted from the Wiener filter reconstruction of the 3D velocity field as a linear low pass filtered highly compressed representation of the CF2 data. An ensemble 2250 random linear realizations of the WMAP/LCDM model has been used to calculate the bulk velocity auto-covariance matrix. We find that the CF2 data is consistent with the WMAP/LCDM model to better than the 2 sigma confidence limits. This provides a further validation that the CF2 database is consistent with the standard model of cosmology.
description: submitted to MNRAS, V2 : solved page sizing problem
Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry
Creators: name: Roelands, Jessica
name: Mall, Raghvendra
name: Almeer, Hossam
name: Thomas, Remy
name: Mohamed, Mahmoud G.
name: Bedri, Shahinaz
name: Al-Bader, Salha Bujassoum
name: Junejo, Kulsoom
name: Ziv, Elad
name: Sayaman, Rosalyn W.
name: Kuppen, Peter J. K.
name: Bedognetti, Davide
name: Hendrickx, Wouter
name: Decock, Julie
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Clinical sciences
Pharmacology and pharmaceutical sciences

description: Breast cancer largely dominates the global cancer burden statistics; however, there are striking disparities in mortality rates across countries. While socioeconomic factors contribute to population-based differences in mortality, they do not fully explain disparity among women of African ancestry (AA) and Arab ancestry (ArA) compared to women of European ancestry (EA). In this study, we sought to identify molecular differences that could provide insight into the biology of ancestry-associated disparities in clinical outcomes. We applied a unique approach that combines the use of curated survival data from The Cancer Genome Atlas (TCGA) Pan-Cancer clinical data resource, improved single-nucleotide polymorphism-based inferred ancestry assignment, and a novel breast cancer subtype classification to interrogate the TCGA and a local Arab breast cancer dataset. We observed an enrichment of BasalMyo tumors in AA patients (38 vs 16.5% in EA, p = 1.30E − 10), associated with a significant worse overall (hazard ratio (HR) = 2.39, p = 0.02) and disease-specific survival (HR = 2.57, p = 0.03). Gene set enrichment analysis of BasalMyo AA and EA samples revealed differences in the abundance of T-regulatory and T-helper type 2 cells, and enrichment of cancer-related pathways with prognostic implications (AA: PI3K-Akt-mTOR and ErbB signaling; EA: EGF, estrogen-dependent and DNA repair signaling). Strikingly, AMPK signaling was associated with opposing prognostic connotation (AA: 10-year HR = 2.79, EA: 10-year HR = 0.34). Analysis of ArA patients suggests enrichment of BasalMyo tumors with a trend for differential enrichment of T-regulatory cells and AMPK signaling. Together, our findings suggest that the disparity in the clinical outcome of AA breast cancer patients is likely related to differences in cancer-related and microenvironmental features.Other Information Published in: npj Breast Cancer
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41523-021-00215-x
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
Creators: name: Zaghlool, Shaza B.
name: Kühnel, Brigitte
name: Elhadad, Mohamed A.
name: Kader, Sara
name: Halama, Anna
name: Thareja, Gaurav
name: Engelke, Rudolf
name: Sarwath, Hina
name: Al-Dous, Eman K.
name: Mohamoud, Yasmin A.
name: Meitinger, Thomas
name: Wilson, Rory
name: Strauch, Konstantin
name: Peters, Annette
name: Mook-Kanamori, Dennis O.
name: Graumann, Johannes
name: Malek, Joel A.
name: Gieger, Christian
name: Waldenberger, Melanie
name: Suhre, Karsten
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry and cell biology

description: DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of NLRC5, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. Our study links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may eventually be targeted in a personalized approach of chronic low-grade inflammation.Other Information Published in: Nature Communications
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41467-019-13831-w
Herrmann, Christian/Hahn, Eberharf (Hg.): Festhalten am Bekenntnis der Hoffnung
Creators: name: Junker, Johannes
Publisher: name: Lutherische Beiträge
Year: 1970

description: Lutherische Beiträge, Bd. 7 Nr. 1 (2002): Lutherische Beiträge, Band 7, Heft 1
Characterization of Heterojunction Rib-Si Solar Cells by EL and DLIT Imaging
Creators: name: Konagai, M.
name: Kondo, R.
name: Ichikawa, Y.
name: Ishikawa, Y.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Characterisation & Simulation Methods for Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 262-265
description: Heterojunction solar cells with a Rib structure are prepared aiming at ultra-thin Si solar cells. In the Rib
structure, the Rib region of about 10% in area ratio mechanically supports the thinned region. In this paper,
evaluation was carried out with a focus on the in-plane characteristic distribution of Rib solar cells. Both
electroluminescence (EL) and dark lock-in thermography (DLIT) imaging were carried out to evaluate the local
electronic properties of Rib solar cells. It was found that EL intensity from Rib-region is 2.2 times larger than EL
from thin-region. The difference in EL intensity corresponds to the difference of Voc, about 23 mV. DLIT imaging
also showed that the current density in the Rig-region is higher than the thin-region. In addition, evaluation by PL
imaging is also carried out. And the relationship between the PL intensity distribution and the Rib wafer thickness
distribution is discussed based on the thickness dependence of the effective carrier lifetime.
AcSel: selecting variables with accuracy in correlated datasets
Creators: name: Nicolas, Jung
name: Bertrand, Frédéric
name: Maumy-Bertrand, Myriam
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: With the emergence of high-throughput technologies, it is possible to measure large amounts of data relatively at low cost. Such situations arise in many fields from sciences to humanities, and variable selection may be of great help to answer challenges that are specific to each of them. Variable selection may allow to know, among all measured variables, which are of interest and which are not. A lot of methods have been proposed to handle this issue, with the Lasso and other penalized regression as special cases. These methods fail in some cases and linear correlation between explanatory variables is the most common of these, especially in big datasets. In this article, we introduce AcSel, a wrapping algorithm able to enhance the accuracy of any variable selection method. To achieve this result, we use intensive computational simulations.
Gene therapy for spinal muscular atrophy: the Qatari experience
Creators: name: Ali, Hossamaldein Gaber
name: Ibrahim, Khalid
name: Elsaid, Mahmoud Fawzi
name: Mohamed, Reem Babiker
name: Abeidah, Mahmoud I. A.
name: Al Rawwas, Azhar Othman
name: Elshafey, Khaled
name: Almulla, Hajer
name: El-Akouri, Karen
name: Almulla, Mariam
name: Othman, Amna
name: Musa, Sara
name: Al-Mesaifri, Fatma
name: Ali, Rehab
name: Shahbeck, Noora
name: Al-Mureikhi, Mariam
name: Alsulaiman, Reem
name: Alkaabi, Saad
name: Ben-Omran, Tawfeg
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Medicinal and biomolecular chemistry

description: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by hypotonia, progressive muscle weakness, and wasting. Onasemnogene abeparvovec (Zolgensma®) is a novel gene therapy medicine, FDA-approved in May 2019 for the treatment of SMA. This study aimed to describe Qatari experience with onasemnogene abeparvovec by reviewing the clinical outcomes of 9 SMA children (7 SMA type 1 and 2 with SMA type 2) aged 4‒23 months treated between November 2019 and July 2020. Children <2 years with 5q SMA with a bi-allelic mutation in the SMN1 gene were eligible for gene therapy. Liver function (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and total bilirubin), platelet count, coagulation profile, troponin-I levels, and motor scores (Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders [CHOP INTEND]), were regularly monitored following gene therapy. All patients experienced elevated AST or ALT, two experienced high prothrombin time, and one experienced elevated bilirubin; all of these patients were asymptomatic. Furthermore, one event of vomiting after infusion was reported in one patient. Significant improvements in CHOP INTEND scores were observed following therapy. This study describes the short-term outcomes and safety of onasemnogene abeparvovec, which is well tolerated and shows promise for early efficacy.Other Information Published in: Gene Therapy
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41434-021-00273-7
Silicon Solar Cells by "DESIJN" (Deposited Silicon Junctions)
Creators: name: Cuevas, A.
name: Yan, D.
name: Phang, S.P.
name: Wan, Y.
name: Macdonald, D.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Homojunction Solar Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 233-237
description: The deposition of silicon films to form the junctions required to make a silicon solar cell has permitted to achieve performance levels never seen before. Until now, such films have been deposited by chemical methods, both for the low temperature approach based on a-Si:H and the high temperature one based on polycrystalline silicon. We present here a novel approach for the latter, based on the physical deposition of silicon and an appropriate dopant element onto an ultrathin SiOx interlayer. The electronic characteristics of these DEposited SIlicon JuNctions are, even at this early stage of development, essentially as good as those formed by chemical deposition in our laboratory. The initial focus of the novel PVD approach has been to develop p+ poly-Si contacts doped in-situ with boron, for which a recombination current density J0p+≈20 fA/cm2, and a contact resistivity c≈10 mΩcm2 have been achieved. These passivating contacts have been implemented as a full-area hole-selective contact on the rear side of p-type silicon wafers, in combination with a phosphorus diffused electron contact on the front side. The best devices fabricated so far have reached an open-circuit voltage of 701 mV and a conversion efficiency of 23%, with ample room for further improvement.
Fast food and sweet intake pattern is directly associated with the prevalence of asthma in a Qatari population
Creators: name: Shi, Zumin
name: El-Obeid, Tahra
name: Meftah, Zainab
name: Alawi, Amal
name: Said, Suad
name: Ganji, Vijay
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Nutrition and dietetics

description: Objective The relationship between dietary patterns and the prevalence of asthma is not well understood. We aimed to investigate the association between dietary patterns and asthma in adults in Qatar. Methods In this study, cross-sectional data from the Qatar Biobank were used (n = 986). Participants were Qatari or long-term Qatar residents aged ≥20 years old. A food frequency questionnaire was used to collect dietary intakes. Three dietary patterns were identified using factor analysis. Multivariable logistic regression was used to assess the association between dietary patterns scores and asthma. Results Among 986 eligible participants, 6.6% (n = 65) reported that they were diagnosed with asthma. Three dietary patterns were identified. These were (1) “Traditional” (high intake of rice, chicken/meat/fish, and breads); (2) “Prudent” (high intake of fruits, vegetables, and fish); and (3) “Fast Food/Sweets” (high intake of desserts, fast food, and soft drinks). The fast food/sweet dietary pattern was associated with increased likelihood of having asthma [comparing high vs. low tertile, OR for asthma = 1.25; 95% CI (1.02–1.54); p = 0.035]. Traditional and Prudent dietary patterns were not associated with the prevalence of asthma. Conclusion The fast food/sweet dietary pattern was directly associated with the prevalence of asthma among adults in Qatar. Reducing the fast foods and sugary-rich foods may be beneficial for respiratory health.Other Information Published in: European Journal of Clinical Nutrition
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41430-021-00959-6
Opto-Electrical Modelling of Periodic Nanostructures, Integrated into Two-Side Contacted Silicon Heterojunction Devices
Creators: name: Razzaq, A.
name: Depauw, V.
name: Filipic, M.
name: Gordon, I.
name: Szlufcik, J.
name: Poortmans, J.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Characterisation & Simulation Methods for Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 238-243
description: This work utilizes numerical simulations for evaluating 2D diffraction gratings as an alternative to
randomly distributed pyramids for front-side texturing. The study is performed in the context of two-side contacted
silicon heterojunction (SHJ) devices as a function of the absorber thickness. Optical simulation studies for a variety of
nano-pattern shapes have been reported previously but these were seldom complemented by electrical modelling. Both
aspects, eventually concluding to a detailed power loss analysis, are addressed in this work. Rigorous coupled wave
analysis (RCWA) method is used for calculating the photo-generation rate profiles which are then coupled to the
electrical model, defined in Sentaurus TCAD. The opto-electrical simulations in this work are performed for four
different nano-pattern shapes that include nano-cylinders, nano-hemispheres, inverted nano-cones and inverted nanopyramids.
Nanostructured SHJ cells based on inverted nano-pyramids are found to reach the highest efficiencies as
they combine the best optical and electrical characteristics.
Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer
Creators: name: Shan, Jingxuan
name: Al-Muftah, Mariam A.
name: Al-Kowari, Moza K.
name: Abuaqel, Sirin W. J.
name: Al-Rumaihi, Khalid
name: Al-Bozom, Issam
name: Li, Pu
name: Chouchane, Lotfi
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Biochemistry and cell biology
Oncology and carcinogenesis

description: Prostate cancer (PC) castration resistance has been linked to the differentiation of PC luminal cells into hormone-refractory neuroendocrine (NE) cells. However, the molecular mechanisms controlling the emergence of lethal NE prostate cancer (NEPC) remain unclear. The present study aimed to investigate the mechanisms underlying the transition from prostate adenocarcinoma to NEPC. The microRNA miR-708 was involved in NE differentiation and was downregulated in NEPC cells and tumor specimens. miR-708 targeted Sestrin-3 to inhibit Forkhead Box O1 (FOXO1) phosphorylation, resulting in apoptosis of prostate adenocarcinoma cells and AKT-inactivated NEPC cells, the latter of which was consistent with the progression of tumor xenografts in mice under miR-708 treatment. In silico analysis of PC and NEPC tumor specimens suggested that the polycomb repressive complex subunit Enhancer of zeste homolog 2 (EZH2) was particularly overexpressed in NEPC. Notably, EZH2 bound to the miR-708 promoter and induced its silencing in NEPC. Inhibition of EZH2 prevented NE differentiation of PC cells. EZH2 expression was regulated by both Cyclin Dependent Kinase 1 (CDK1) and Wnt signaling. Silencing transcription factor 4 (TCF4), as a key protein in Wnt signaling, prevented NEPC formation. These results provide a molecular basis for the roles of miR-708 and EZH2 in NE differentiation in PC and highlight a new paradigm in NEPC formation and survival.Other Information Published in: Cell Death Discovery
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41420-019-0218-y
Complexity of ITL model checking: some well-behaved fragments of the interval logic HS
Creators: name: Molinari, A.
name: Montanari, A.
name: Peron, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Computational Complexity (cs.CC)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: Model checking has been successfully used in many computer science fields, including artificial intelligence, theoretical computer science, and databases. Most of the proposed solutions make use of classical, point-based temporal logics, while little work has been done in the interval temporal logic setting. Recently, a non-elementary model checking algorithm for Halpern and Shoham's modal logic of time intervals HS over finite Kripke structures (under the homogeneity assumption) and an EXPSPACE model checking procedure for two meaningful fragments of it have been proposed. In this paper, we show that more efficient model checking procedures can be developed for some expressive enough fragments of HS.
Status of the EU H2020 Disc Project: European Collaboration in Research and Development of High Efficient Double Side Contacted Cells with Innovative Carrier-Selective Contacts
Creators: name: Min, B.
name: Wietler, T.
name: Bordihn, S.
name: Peibst, R.
name: Desrues, T.
name: Carroy, P.
name: Jourdan, J.
name: Hermle, M.
name: Feldmann, F.
name: Bartsch, J.
name: Allebée, C.
name: Ding, L.
name: Horzel, J.
name: Lachowicz, A.
name: Diaz Leon, J.J.
name: Ingenito, A.
name: Haug, F.-J.
name: Schneiderlöchner, E.
name: Linss, V.
name: Köhler, R.
name: Lüdemann, K.
name: Campa, A.
name: Bokalic, M.
name: Topic, M.
name: Zwegers, M.
name: Hartlin, B.
name: Field, B.
name: Bénédicte, B.
name: Richter, A.
name: Adam, Z.
name: Penaud, J.
name: Filonovich, S.
name: Harder, N.
name: Marcon, E.
name: Chupin, J.
name: Tamini, F.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Heterojunction Solar Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 229-232
description: The DISC project addresses the development of key technologies for the next generation of high-performance photovoltaic solar cells and modules. Our approach is to fully exploit the potential of silicon to its maximum by the use of passivating contacts or carrier selective contacts and junctions. Such contacts allow for simple, non-patterned double-side contacted device architecture and an enhancement of the energy yield, which will be key elements for achieving very low levelized costs of electricity. In this paper, selected highlights are presented concerning the first 18 months in the development of cell and module components such as In-free transparent conductive oxide layers with low sputtering damage. The synergies and results created within DISC will be also interesting for a drop-in combination with other solar cell and module technologies.
Layer-dependent anisotropic electronic structure of freestanding quasi-two-dimensional MoS$_2$
Creators: name: Hong, Jinhua
name: Li, Kun
name: Jin, Chuanhong
name: Zhang, Xixiang
name: Zhang, Ze
name: Yuan, Jun
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The anisotropy of the electronic transition is a well-known characteristic of low-dimensional transition-metal dichalcogenides, but their layer-thickness dependence has not been properly in- vestigated experimentally until now. Yet, it not only determines the optical properties of these low-dimensional materials, but also holds the key in revealing the underlying character of the elec- tronic states involved. Here we used both angle-resolved electron energy-loss spectroscopy and spectral analysis of angle-integrated spectra to study the evolution of the anisotropic electronic transition involving the low energy valence electrons in the freestanding MoS$_2$ layers with different thicknesses. We are able to demonstrate that the well-known direct gap at 1.8 eV is only excited by the in-plane polarized field while the out-of-plane polarized optical gap is 2.4$\pm$0.2 eV in monolayer MoS$_2$. This contrasts with the much smaller anisotropic response found for the indirect gap in the few-layer MoS$_2$ systems. In addition, we determined that the joint density of states associated with the indirect gap transition in the multilayer systems and the corresponding indirect transition in the monolayer case has a characteristic three-dimensional-like character. We attribute this to the soft-edge behavior of the confining potential and it is an important factor when considering the dynamical screening of the electric field at the relevant excitation energies. Our result provides a logical explanation, for the large sensitivity of the indirect transition to thickness variation compared with that for the direct transition, in terms of quantum confinement.
description: 12 pages, 10 figures. This is an updated version of the paper first posted as arXiv:1409.1409
Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFβ and focal adhesion kinase (FAK) signaling
Creators: name: Vishnubalaji, Radhakrishnan
name: Shaath, Hibah
name: Elkord, Eyad
name: Alajez, Nehad M.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Biochemistry and cell biology
Oncology and carcinogenesis

description: Long non-coding RNAs (lncRNAs) represent a class of epigenetic regulators implicated in a number of physiological and pathological conditions. Herein, we characterized the lncRNA expression portrait from 837 patients with invasive breast cancer and 105 normals from the cancer genome atlas (TCGA), which revealed eighteen upregulated and forty-six downregulated lncRNAs. Clustering analysis revealed distinct lncRNA profile for the triple negative breast cancer (TNBC) and normal breast tissue, while less separation was observed among the HER2+HR+, HER2+HR−, HER2−HR+ molecular subtypes. LINC01614, and LINC01235 correlated with worse disease-free survival (DFS), while the expression of lnc-LRR1–1, lnc-ODF3B-2, AC015712.5, lnc-LAMB3–1, lnc-SPP2–3, and lnc-MAP9–2 correlated with better DFS. The expression of LINC01235 correlated with worse overall survival (OS), while the expression of MIR205HG, lnc-MAP2K6–5, FGF14-AS2, lnc-SPP2–3 correlated with better OS. Highest expression of LINC01614 was observed in progesterone receptor (PR)+, Estrogen receptor (PR)+, and HER2+ tumors, while lowest expression was in TNBC. Concordantly, LINC01614 was highly expressed in the luminalB/HER2+ subtype from the SRP062132 dataset. Elevated expression of LINC01614 was subsequently validated in primary breast cancer tissue and breast cancer cell lines. Bioinformatics and pathway analyses on LINC01614high vs. LINC01614low BC tissue revealed TGFβ1 and ECM as the most activated networks in LINC01614high tumors. Concordantly, strong correlation between the expression of LINC01614 and COL10A1 (R2 = 0.6929), SPOCK1 (R2 = 0.5156), ZEB1 (R2 = 0.3372), TGFBI (R2 = 0.2978), TGFB1 (R2 = 0.1985), ACTA2 (R2 = 0.1833), and TAGLN (R2 = 0.1909) was observed. Mechanistically, exogenous TGFB1 induced LINC01614 expression in the BT474 triple positive BC model, while small-molecule inhibition of transforming growth factor β (TGFβ, SB-431542) or focal adhesion kinase (FAK, PF-573228) abrogated LINC01614 expression. Our data revealed the lncRNA transcription landscape in breast cancer and its molecular subtypes. Our data provide novel insight implicating LINC01614 as unfavorable prognostic marker in BC, its association with the HR+/HER2+ BC molecular subtype and its regulation by TGFβ and FAK signaling.Other Information Published in: Cell Death Discovery
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41420-019-0190-6
Inorganic Cesium Carbonate Electron Transport Layer for High Efficiency Perovskite Solar Cells
Creators: name: Hossain, M.I.
name: Zimmermann, I.
name: Tabet, N.
name: Nazeeruddin, M.K.
name: Belaidi, A.
Publisher: name: WIP
Year: 2018
Subjects: New Materials and Concepts for Photovoltaic Devices
New Materials and Concepts for Cells and Modules

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 208-209
description: In this work, we have explored the possibility to develop efficient double cation (FAPbI3)0.85(MAPbBr3)0.15 perovskite solar cells using inorganic n-type Cesium Carbonate (Cs2CO3) as electron transport material (ETM), which can be synthesized at low temperature and integrating this type of ETM with compact TiO2 leads to 17% power conversion efficiency (PCE) under one sun illumination. External quantum efficiency (EQE) data yields around 85% of incident photon to electron conversion and integrated short circuit current extracted from aforementioned data confirms the short circuit current obtained from the IV test with a close agreement. Cs2CO3 (6wt%)/Perovskite/Spiro-OMETAD structures w/o any types of TiO2 ETM has shown a short-circuit current density (Jsc) of 15.40 mA/cm2, open-circuit voltage (Voc) of 1.023 V, fill factor (FF) of 51.7%, and a PCE of 8.14%. Interestingly, c-TiO2/Cs2CO3(0.2wt%)/Perovskite/Spiro-OMETAD structure w/o meso-TiO2 boosts the performance with a short-circuit current density (Jsc) of 22.26 mA/cm2, open-circuit voltage (Voc) of 1.054 V, fill factor (FF) of 71.6%, and a PCE of 16.80% confirming Cs2CO3 as an alternative ETM to meso-TiO2 modifies compact-TiO2 surface. Also, high open circuit voltage and short circuit current values can be attributed to the passivation of defect states on TiO2 surface resulting in effective charge transfer between perovskite and ETM layers. Hence, a thin layer of Cs2CO3 can replace thick and meso-TiO2 with low process temperature (<200oC) with an improved efficiency.
Raw data for: Navigating techno-stress: A qualitative exploration of university faculty's experiences and perspectives in the Peruvian context amidst the return to classes and the post-COVID-19 era
Creators: name: Suyo-Vega, Josefina Amanda
name: Meneses-La-Riva, Monica Elisa
name: Fernández-Bedoya, Víctor Hugo
Publisher: name: Zenodo
Year: 2023

description: Raw data for: Navigating techno-stress: A qualitative exploration of university faculty's experiences and perspectives in the Peruvian context amidst the return to classes and the post-COVID-19 era
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
Creators: name: Al-toub, Mashael
name: Almohawes, Mohammad
name: Vishnubalaji, Radhakrishnan
name: Alfayez, Musaad
name: Aldahmash, Abdullah
name: Kassem, Moustapha
name: Alajez, Nehad M.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Biochemistry and cell biology
Oncology and carcinogenesis

description: The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM) derived from human bone marrow stromal stem cells (hBMSCs). Regarding the underlying molecular mechanism, we have identified CXCR7 as highly expressed by MCF7 cells and that it mediated the enhanced growth in response to hBMSC CM. Regarding the clinical relevance, we found an inverse correlation between the level of tumor gene expression of CXCR7 in bladder, breast, cervical, kidney, liver, lung, pancreatic, stomach, and uterine cancers, and patients’ overall survival. Interestingly, significant positive correlation between CXCR7 and CXCL12 gene expression (Pearson = 0.3, p = 2.0 × 10–16) was observed in breast cancer patients, suggesting a biological role for the CXCR7/CXCL12 genetic circuit in breast cancer biology. Our data provide insight into the molecular mechanisms by which stromal-derived microenvironmental cues mediate CXCR7 signaling and growth enhancement of breast cancer cells. Therapeutic targeting of this circuit might provide novel therapeutic opportunity for breast cancer.Other Information Published in: Cell Death Discovery
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41420-019-0169-3
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
Creators: name: Hildebrand, Joanne M.
name: Lo, Bernice
name: Tomei, Sara
name: Mattei, Valentina
name: Young, Samuel N.
name: Fitzgibbon, Cheree
name: Murphy, James M.
name: Fadda, Abeer
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Biochemistry and cell biology
Oncology and carcinogenesis

description: Maturity-onset diabetes of the young, MODY, is an autosomal dominant disease with incomplete penetrance. In a family with multiple generations of diabetes and several early onset diabetic siblings, we found the previously reported P33T PDX1 damaging mutation. Interestingly, this substitution was also present in a healthy sibling. In contrast, a second very rare heterozygous damaging mutation in the necroptosis terminal effector, MLKL, was found exclusively in the diabetic family members. Aberrant cell death by necroptosis is a cause of inflammatory diseases and has been widely implicated in human pathologies, but has not yet been attributed functions in diabetes. Here, we report that the MLKL substitution observed in diabetic patients, G316D, results in diminished phosphorylation by its upstream activator, the RIPK3 kinase, and no capacity to reconstitute necroptosis in two distinct MLKL−/− human cell lines. This MLKL mutation may act as a modifier to the P33T PDX1 mutation, and points to a potential role of impairment of necroptosis in diabetes. Our findings highlight the importance of family studies in unraveling MODY’s incomplete penetrance, and provide further support for the involvement of dysregulated necroptosis in human disease.Other Information Published in: Cell Death & Disease
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41419-021-03636-5
Solder Joint Analysis of Tin-Lead and Bismuth Based Lead Free PV Ribbons in High Throughput Manufacturing
Creators: name: Pujari, N.S.
name: Sundaramurthy, J.
name: Sarkar, S.
name: Poh, E.
name: Bilgrien, C.
Publisher: name: WIP
Year: 2018
Subjects: New Materials and Concepts for Photovoltaic Devices
New Materials and Concepts for Cells and Modules

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 210-214
description: PV module manufacturers increasingly require higher throughput production lines with higher degrees of automation and flexibility. Establishing an electrical connection between solar cells in a module not only defines the final shape and output power of the solar panel, depending on the strategy applied it but also strongly impacts yield and throughput of the entire module factory. There are not too many reports on solder joint analysis in high manufacturing scenario. This paper analyses solder joints and factors affecting solder joints in high throughput manufacturing. Paper also report performance of new lead free solder, EcoSol™ along with standard tin lead ribbon in an automated tabbing machine. We found that under identical conditions, the solder joints in lead and lead free ribbons were comparable and peel strength of >2.5 N/mm on front and back side of the cell obtained. DOE results reveal that the cell metallization play an important role in determining quality of solder joints. Grade A PERC cells yielded higher peel strength compared to p-type c-Si cells due to the smooth surface topology. Similarly, flux having good wetting time performed better. Ribbon alignment was identified as one of the major causes of the weak solder joints. Due to decreased ribbon and bus bar size, this problem might occur frequently. Microscopic investigation yielded, absence of IMC (intermetallic compound) in either of the ribbons due to rapid production speed. Only diffusion of tin into silver matrix was observed. This, however, does not have any effect on peel strength and cohesive failure was evident from fracture surface analysis.
Electron Selective La:BaSnO3 Thin Films via Pulsed Laser Deposition (PLD) : Effect of Deposition Pressure
Creators: name: Kumar, A.
name: Singh, A.K.
name: Balasubramaniam, K.R.
Publisher: name: WIP
Year: 2018
Subjects: New Materials and Concepts for Photovoltaic Devices
New Materials and Concepts for Cells and Modules

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 184-187
description: The effect of O2 partial pressure during deposition on the properties of 1% Lanthanum doped Barium Stannate (LBSO) thin films is studied. X-ray diffraction revealed the growth of [00l] oriented LBSO films at higher O2 partial pressures. The transparency of the films also increases as we increase the deposition pressures. Around 300 nm thick films deposited at PO2 ≥ 0.56 mTorr, have ~80% transmittance in visible range (400-700 nm). It was observed that either extremities of deposition pressure were unfavourable for superior electrical properties. Values of electron concentration (ne) and Hall mobility (μ) was found to be 6.09×1020 cm-3 and 13.30 cm2/V-s, for the films deposited at 5.6 mTorr PO2. The high figure of merit (FoM: 2.08 mS) of LBSO is comparable to that of other commercially available TCOs and thus makes it a good candidate for the transparent electron selective layer in solar cells.
Learning from the Past to Look Beyond the Roadmap of PERC Si Solar Cell Mass Production
Creators: name: Altermatt, P.P.
name: Yang, Y.
name: Chen, Y.
name: Chen, D.
name: Zhang, X.
name: Xu, G.
name: Feng, Z.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Manufacturing & Production of Si Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 215-221
description: Past patterns of cell and module efficiency, fabrication cost, metallization, and growing independence from the IC industry are used to extrapolate progress into the future. It is concluded that the development of cheap Si bottom cells for tandems should be accelerated, scarce materials be avoided, and for passivated contacts to come into mainstream Si photovoltaics, it may be most advantageous to introduce them into the PERC fabrication process with the least required changes. Once both electron and hole contacts are passivated in the mainstream, it may be easier to switch from p- to n-type wafers to take advantage of higher bulk lifetimes, compared to switching to n-type cells like PERT and HJT now. In this sense, the million dollar question ‘p-type or n-type?’ may be posed too early, and concentrating the efforts on further developing PERC may be more successful. For this, a transparent passivated contact replacing the phosphorus emitter in PERC cells is suggested.