cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(502189) Irene Clementine Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sonnenfleckenzeichnung Nr. 130.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.06.2010, 08:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 104.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.05.2010, 10:15, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
(502191) Samuel Donkin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach
Creators: name: Xue, F.
name: Galea, S.
name: Martin, C.L.
name: Koenen, K.
name: Qu, A.
name: Wildman, D.E.
name: Wani, A.H.
name: Uddin, M.
name: Kim, G.S.
name: Ratanatharathorn, A.
name: Aiello, A.E.
Publisher: name: Elsevier B.V.
Year: 2021

description: Background: A range of factors have been identified that contribute to greater incidence, severity, and prolonged course of post-traumatic stress disorder (PTSD), including: comorbid and/or prior psychopathology; social adversity such as low socioeconomic position, perceived discrimination, and isolation; and biological factors such as genomic variation at glucocorticoid receptor regulatory network (GRRN) genes. This complex etiology and clinical course make identification of people at higher risk of PTSD challenging. Here we leverage machine learning (ML) approaches to identify a core set of factors that may together predispose persons to PTSD. Methods: We used multiple ML approaches to assess the relationship among DNA methylation (DNAm) at GRRN genes, prior psychopathology, social adversity, and prospective risk for PTS severity (PTSS). Results: ML models predicted prospective risk of PTSS with high accuracy. The Gradient Boost approach was the top-performing model with mean absolute error of 0.135, mean square error of 0.047, root mean square error of 0.217, and R2 of 95.29%. Prior PTSS ranked highest in predicting the prospective risk of PTSS, accounting for >88% of the prediction. The top ranked GRRN CpG site was cg05616442, in AKT1, and the top ranked social adversity feature was loneliness. Conclusion: Multiple factors including prior PTSS, social adversity, and DNAm play a role in predicting prospective risk of PTSS. ML models identified factors accounting for increased PTSS risk with high accuracy, which may help to target risk factors that reduce the likelihood or course of PTSD, potentially pointing to approaches that can lead to early intervention. Limitation: One of the limitations of this study is small sample size.
title: Recent Onera Flow Control Research on High-Lift Configurations
Creators: name: Brunet, V.
name: Dandois, J.
name: Verbeke, C.
Publisher: name: ONERA
Year: 2013

description: This paper concerns the recent and most representative work performed at Onera on
the application of flow control technologies to high-lift systems of aircraft wings.
Two different objectives are considered. First, keeping present architecture, flow
control could either enhance the aerodynamic performance (mainly mean and stall
lift coefficients) or simplify the mechanisms (flap gap or size). Secondly, a drastic
geometry simplification, very attractive for aircraft manufacturers, like slot or even slat
suppression, leads to a strong depletion of aerodynamic performance. In that case, the
objective of flow control is to retrieve as much as possible the reference airfoil performance.
Various flow control devices, from simple mechanical or fluidic vortex generators
to pulsed blowing, are considered. Combined numerical and experimental studies
are presented and the efficiency of the control is discussed.
description: Journal Aerospace Lab, Issue 6, June 2013; ISSN: 2107-6596
Swift/UVOT grism monitoring of NGC 5548 in 2013: an attempt at MgII reverberation mapping
Creators: name: Cackett, E. M.
name: Gultekin, K.
name: Bentz, M. C.
name: Fausnaugh, M. M.
name: Peterson, B. M.
name: Troyer, J.
name: Vestergaard, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Reverberation-mapping-based scaling relations are often used to estimate the masses of black holes from single-epoch spectra of AGN. While the radius-luminosity relation that is the basis of these scaling relations is determined using reverberation mapping of the H$β$ line in nearby AGN, the scaling relations are often extended to use other broad emission lines, such as MgII, in order to get black hole masses at higher redshifts when H$β$ is redshifted out of the optical waveband. However, there is no radius-luminosity relation determined directly from MgII. Here, we present an attempt to perform reverberation mapping using MgII in the well-studied nearby Seyfert 1, NGC 5548. We used Swift to obtain UV grism spectra of NGC 5548 once every two days from April to September 2013. Concurrent photometric UV monitoring with Swift provides a well determined continuum lightcurve that shows strong variability. The MgII emission line, however, is not strongly correlated with the continuum variability, and there is no significant lag between the two. We discuss these results in the context of using MgII scaling relations to estimate high-redshift black hole masses.
description: 8 pages, 7 figures, accepted for publication in ApJ
Sonnenfleckenzeichnung Nr. 70.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.04.2010, 08:30, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 91.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.04.2010, 08:00, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Perceived barriers to commuter and exercise bicycling in U.S. adults: The 2017 National Household Travel Survey
Creators: name: Evenson, K.R.
name: Kontou, E.
name: McDonald, N.C.
name: Porter, A.K.
Publisher: name: Elsevier Ltd
Year: 2020

description: Introduction: Bicycling is a type of physical activity associated with positive health outcomes, but many barriers exist to regular bicycling for recreation and transportation. The objective of this study was to describe self-reported barriers to bicycling overall, and by bicycling domain, among a national sample of persons aged 16 and above that reported bicycling outside in the past week. Methods: This analysis, conducted in 2019, utilized data from the United States (US) Department of Transportation's 2017 National Household Travel Survey (NHTS). Weighted point estimates and 95% confidence intervals were calculated for reported barriers to bicycling by category of bicyclist: exercise-exclusive, multi-use, and commuter. Results: The final analytic sample was 18,189, representing approximately 7% of the US population (N = 20,911,680). Barriers that prevented bicycling more was reported by 37.9% of the US population of adult bicyclists (95% CI 37.2, 38.6). Barriers related to safety were more commonly reported (31.9% of total bicyclists), compared to barriers related to infrastructure (22.1% of total bicyclists). Safety-related barriers were more commonly reported among multi-use bicyclist (33.7% vs. 30.9% of exercise-exclusive). Commuter bicyclists reported infrastructure barriers the least (13.9% vs. 22.7% of exercise-exclusive). The most commonly reported single barrier to bicycling more, regardless of bicycling category, was heavy traffic (10.3% of total bicyclists), followed by no nearby paths or trails (7.6% of total bicyclists). Overall, distribution of individual barriers was similar across categories of bicyclists: exercise-exclusive, multi-use, and commuter. Conclusions: Heavy traffic and lack of separated paths or trails were the most frequently identified barriers to bicycling more. Communities wishing to promote bicycling for transportation, recreation, or both should consider how traffic reduction strategies and changes in the built environment could make bicycling safer and more accessible.
An Adaptive MAC Protocol for Wireless LANs
Creators: name: Jamali, Amin
name: Hemami, Seyed Mostafa Safavi
name: Berenjkoub, Mehdi
name: Saidi, Hossein
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper focuses on contention-based Medium Access Control (MAC) protocols used in Wireless Local Area Networks (WLANs). We propose a novel MAC protocol called Adaptive Backoff Tuning MAC (ABTMAC) based on IEEE 802.11 DCF. In our proposed MAC protocol, we utilize a fixed transmission attempt rate and each node dynamically adjusts its backoff window size considering the current network status. We determined the appropriate transmission attempt rate for both cases where the Request-To-Send/Clear-To-Send (RTS/CTS) mechanism was and was not employed. Robustness against performance degradation caused by the difference between desired and actual values of the attempt rate parameter is considered when setting it. The performance of the protocol is evaluated analytically and through simulations. These results indicate that a wireless network utilizing ABTMAC performs better than one using IEEE 802.11 DCF.
description: 11 pages, 13 figures
QED Corrections to Hadronic Processes in Lattice QCD
Creators: name: Carrasco, N.
name: Lubicz, V.
name: Martinelli, G.
name: Sachrajda, C. T.
name: Tantalo, N.
name: Tarantino, C.
name: Testa, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper, for the first time a method is proposed to compute electromagnetic effects in hadronic processes using lattice simulations. The method can be applied, for example, to the leptonic and semileptonic decays of light or heavy pseudoscalar mesons. For these quantities the presence of infrared divergences in intermediate stages of the calculation makes the procedure much more complicated than is the case for the hadronic spectrum, for which calculations already exist. In order to compute the physical widths, diagrams with virtual photons must be combined with those corresponding to the emission of real photons. Only in this way do the infrared divergences cancel as first understood by Bloch and Nordsieck in 1937. We present a detailed analysis of the method for the leptonic decays of a pseudoscalar meson. The implementation of our method, although challenging, is within reach of the present lattice technology.
description: 38 pages, 14 figures
Sonnenfleckenzeichnung Nr. 170.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.07.2010, 07:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
title: Passive Control of Cavity Flows
Creators: name: Yamouni, S.
name: Mettot, C.
name: Sipp, D.
name: Jacquin, L.
Publisher: name: ONERA
Year: 2013

description: This paper deals with cavity flow physics and its passive control by means of a
spanwise cylinder. Two configurations are considered. First, a laminar study of a
flow over an unconfined square cavity at a low Reynolds number (7500) is presented.
Global stability results are shown, allowing the identification of the driving mechanisms
of the cavity flow: the aeroacoustic feedback mechanism and the acoustic resonance
mechanism. When both mechanisms interact, the growth rate of the global
modes is seen to display a local maximum. At low Mach numbers, we suggest that it is
still the feedback aeroacoustic mechanism that selects the frequency mode, the acoustic
resonance mechanism only enhancing the response. Second, we study the dynamics
of a turbulent deep cavity flow in a transonic regime. Global modes and sensitivity
results are shown and compared to experimental data, with and without control cylinder.
Concerning the baseline (without control), RANS and URANS simulations, based
on the k-ω model of Wilcox, display very good agreement with experiments. Also, the
sensitivity map obtained numerically is extremely close to the experimental control map
obtained by moving a small control cylinder in the usptream boundary layer and the
shear-layer. Different interpretation elements are discussed.
description: Journal Aerospace Lab, Issue 6, June 2013; ISSN: 2107-6596
(502183) John J. Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Numerical and Experimental Investigations of Flow Control in Axial Compressors
Creators: name: Marty, J.
name: Castillon, L.
name: Boniface, J.-C.
name: Burguburu, S.
name: Godard, A.
Publisher: name: ONERA
Year: 2013

description: The increase of the thrust-to-weight ratio of modern gas-turbine engines results in
higher loads and a reduced number of blades and stages for the compressor. The
designer must ensure the acceptable performance of each compressor stage (efficiency
and stable operating range) and control the rising risk of blade boundary layer
separation. This can be obtained using passive or active control devices which act
on the behavior of the tip leakage flows or the endwall corner stall when the operating
point gets closer to the stall or surge limit (compressor). This study focuses on casing
treatments, with axisymmetrical and non-axisymmetrical slots, on injection or recirculating
grooves, which are efficient approaches to extend the stable operating range,
especially by increasing the stall margin of a compressor system while the efficiency
penalty must remain as small as possible. The hub corner stall is controlled by aspirated
compressor and vortex generators.
description: Journal Aerospace Lab, Issue 6, June 2013; ISSN: 2107-6596
TWO-SIGMA: A novel two-component single cell model-based association method for single-cell RNA-seq data
Creators: name:  Weng, C.
name:  Li, Y.
name: Van Buren, E.
name:  Li, Y.
name:  Wu, D.
name:  Jin, F.
name: Van Buren, E.
name:  Hu, M.
name:  Li, Y.
name:  Weng, C.
name:  Li, Y.
name:  Jin, F.
name:  Wu, D.
name:  Hu, M.
Publisher: name: Wiley-Liss Inc.
Year: 2021

description: In this paper, we develop TWO-SIGMA, a TWO-component SInGle cell Model-based Association method for differential expression (DE) analyses in single-cell RNA-seq (scRNA-seq) data. The first component models the probability of “drop-out” with a mixed-effects logistic regression model and the second component models the (conditional) mean expression with a mixed-effects negative binomial regression model. TWO-SIGMA is extremely flexible in that it: (i) does not require a log-transformation of the outcome, (ii) allows for overdispersed and zero-inflated counts, (iii) accommodates a correlation structure between cells from the same individual via random effect terms, (iv) can analyze unbalanced designs (in which the number of cells does not need to be identical for all samples), (v) can control for additional sample-level and cell-level covariates including batch effects, (vi) provides interpretable effect size estimates, and (vii) enables general tests of DE beyond two-group comparisons. To our knowledge, TWO-SIGMA is the only method for analyzing scRNA-seq data that can simultaneously accomplish each of these features. Simulations studies show that TWO-SIGMA outperforms alternative regression-based approaches in both type-I error control and power enhancement when the data contains even moderate within-sample correlation. A real data analysis using pancreas islet single-cells exhibits the flexibility of TWO-SIGMA and demonstrates that incorrectly failing to include random effect terms can have dramatic impacts on scientific conclusions. TWO-SIGMA is implemented in the R package twosigma available at https://github.com/edvanburen/twosigma.
Sonnenfleckenzeichnung Nr. 112.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.05.2010, 08:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
(502185) John Harold [Harold J.] Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sonnenfleckenzeichnung Nr. 210.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.09.2010, 10:30, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Parvalbumin-expressing interneurons in prelimbic cortex regulate social bonding
Creators: name: Bryksa, Anna
name: Winiarski, Maciej
name: Borowska, Joanna
name: Łęski, Szymon
name: Knapska, Ewelina
name: Puścian, Alicja
Publisher: name: Zenodo
Year: 2020
Subjects: PV-expressing neurons, Eco-HAB, prelimbic cortex, sociability, social behaviour, PSAM/PSEM, chemogenetics

description: Although much is known about the neuroanatomy of social behavior, still the functional circuitry of kinship is poorly understood. As some studies indicate a crucial role of the activity of prefrontal cortex in social attachment, we investigated the effects of the cell-specific induction of inhibition in its prelimbic part (PL). Specifically, we artificially activated parvalbumin(PV)-expressing inhibitory neurons in the PL and evaluated its influence on mouse bonding behavior and interest in familiar social stimuli. Animals were tested in Eco-HAB, an ecologically relevant, RFID-based system for assessment of sociability in group-housed mice. Eco-HAB enables continuous, individualized measurement of voluntary social behavior in an environment unconfounded by the presence of humans. Using genetically modified mice selectively expressing Cre protein under the PV promoter combined with the PSAM/PSEM chemogenetic approach, we performed a time-constrained, cell-specific stimulation of the PV neurons in the PL and tested subjects social behavior in the Eco-HAB during the 90-minute period following the systemic administration of the PSEM. Furthermore we also examined if activation of the PV cells interrupts social learning about reward or punishment. To that end, mice were tested in the IntelliCage system, which enables automated assessment of cognitive abilities in group-housed rodents. We show that PL-constrained chemogenetic excitation of the PV neurons impairs in-cohort sociability and reduces interest in familiar social stimuli. Notably, such manipulation of neuronal activity does not alter approach to novel social stimuli and social learning, indicating distinctive mechanisms for expression of kinship. Our research reveals a specific role of the PV cells in the PL in maintenance of social structure and in sustaining ongoing interest in familiar conspecifics. Thus, presented data lays foundation for understanding neural underpinnings of social attachment.
Establishing risk factors and outcomes for congenital hypothyroidism with gland in situ using population-based data linkage methods: study protocol.
Creators: name: Ruiz Nishiki, Milagros
name: Cabecinha, Melissa
name: Knowles, Rachel
name: Peters, Catherine
name: Aitkenhead, Helen
name: Ifederu, Adeboye
name: Schoenmakers, Nadia
name: Sebire, Neil J
name: Walker, Erin
name: Hardelid, Pia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Protocol
1506
epidemiology
ethics
neonatology

description: INTRODUCTION: There has been an increase in the birth prevalence of congenital hypothyroidism (CH) since the introduction of newborn screening, both globally and in the UK. This increase can be accounted for by an increase in CH with gland in situ (CH-GIS). It is not known why CH-GIS is becoming more common, nor how it affects the health, development and learning of children over the long term. Our study will use linked administrative health, education and clinical data to determine risk factors for CH-GIS and describe long-term health and education outcomes for affected children. METHODS AND ANALYSIS: We will construct a birth cohort study based on linked, administrative data to determine what factors have contributed to the increase in the birth prevalence of CH-GIS in the UK. We will also set up a follow-up study of cases and controls to determine the health and education outcomes of children with and without CH-GIS. We will use logistic/multinomial regression models to establish risk factors for CH-GIS. Changes in the prevalence of risk factors over time will help to explain the increase in birth prevalence of CH-GIS. Multivariable generalised linear models or Cox proportional hazards regression models will be used to assess the association between type of CH and school performance or health outcomes. ETHICS AND DISSEMINATION: This study has been approved by the London Queen Square Research Ethics Committee and the Health Research Authority's Confidentiality Advisory Group CAG. Approvals are also being sought from each data provider. Obtaining approvals from CAG, data providers and information governance bodies have caused considerable delays to the project. Our methods and findings will be published in peer-reviewed journals and presented at academic conferences.
(502186) Stella Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sonnenfleckenzeichnung Nr. 229.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.09.2010, 07:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 249.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.10.2010, 07:15, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: Isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver
Creators: name: Hwang, S.
name: Horita, D.A.
name: Kirchner, D.R.
name: Zeisel, S.H.
name: Friday, W.B.
name: Stegall, J.M.
Publisher: name: Oxford University Press
Year: 2021

description: Background: Choline deficiency has numerous negative health consequences; although the preponderance of the US population consumes less than the recommended Adequate Intake (AI), clinical assessment of choline status is difficult. Further, several pathways involved in primary metabolism of choline are estrogen-sensitive and the AI for premenopausal women is lower than that for men. Objectives: We sought to determine whether in vivo magnetic resonance spectroscopy (MRS) of liver and/or isotope-dilution MS of plasma could identify biomarkers reflective of choline intake (preregistered primary outcomes 1 and 2, secondary outcome 1). Determination of whether biomarker concentrations showed sex dependence was a post hoc outcome. This substudy is a component of a larger project to identify a clinically useful biomarker panel for assessment of choline status. Methods: In a double-blind, randomized, crossover trial, people consumed 3 diets, representative of ∼100%, ∼50%, and ∼25% of the choline AI, for 2-wk periods. We measured the concentrations of choline and several metabolites using 1H single-voxel MRS of liver in vivo and using 2H-labeled isotope dilution MS of several choline metabolites in extracted plasma. Results: Plasma concentrations of 2H9-choline, unlabeled betaine, and 2H9-betaine, and the isotopic enrichment ratio (IER) of betaine showed highly significant between-diet effects (q < 0.0001), with unlabeled betaine concentration decreasing 32% from highest to lowest choline intake. Phosphatidylcholine IER was marginally significant (q = 0.03). Unlabeled phosphatidylcholine plasma concentrations did not show between-diet effects (q = 0.34). 2H9 (trimethyl)-phosphatidylcholine plasma concentrations (q = 0.07) and MRS-measured total soluble choline species liver concentrations (q = 0.07) showed evidence of between-diet effects but this was not statistically significant. Conclusions: Although MRS is a more direct measure of choline status, variable spectral quality limited interpretation. MS analysis of plasma showed clear correlation of plasma betaine concentration, but not plasma phosphatidylcholine concentration, with dietary choline intake. Plasma betaine concentrations also correlate with sex status (premenopausal women, postmenopausal women, men).
Sonnenfleckenzeichnung Nr. 261.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.11.2010, 09:15, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Seroepidemiology of SARS-CoV-2 infections in an urban population-based cohort in León, Nicaragua
Creators: name: Toval-Ruíz, C.
name: Munguia, N.
name: Bucardo, F.
name: González, F.
name: De Silva, A.M.
name: Bowman, N.
name: Cuadra, E.C.
name: Blandón, P.
name: Vielot, N.A.
name: Sciaudone, M.
name: Gutierrez, L.
name: Becker-Dreps, S.
name: Rubinstein, R.
name: Premkumar, L.
Publisher: name: Cambridge University Press
Year: 2021

description: In a Nicaraguan population-based cohort, SARS-CoV-2 seroprevalence reached 28% in the first 6 months of the country's epidemic and reached 35% 6 months later. Immune waning was uncommon. Individuals with a seropositive household member were over three times as likely to be seropositive themselves, suggesting the importance of household transmission.
Rocket propulsion optimisation and non-optimum losses: various maxima and non-linear scaling
Creators: name: Carton, Dennis
Publisher: name: Loughborough University
Year: 2020
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Rocket propulsion optimisation and non-optimum losses: various maxima and non linear scaling
Sonnenfleckenzeichnung Nr. 246.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.10.2010, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Coronavirus disease 2019 (COVID-19) research agenda for healthcare epidemiology
Creators: name: Milstone, A.M.
name: Mody, L.
name: Sickbert-Bennett, E.
name: Monsees, E.A.
name: Krein, S.L.
name: Vaughn, V.M.
name: Keller, S.C.
name: Ziegler, M.J.
name: Diekema, D.J.
name: Ellingson, K.D.
name: SHEA Research Committee
name: Morgan, D.J.
name: Lauring, A.S.
name: Klein, E.Y.
name: Anderson, D.J.
name: Chiotos, K.
name: Saint, S.
name: Donskey, C.J.
name: Pfeiffer, C.D.
name: Livorsi, D.J.
name: Merrill, K.
name: Skelton, F.
name: Kwon, J.H.
name: Gilmartin, H.M.
name: Bischoff, W.E.
name: Perri, L.P.
name: Suda, K.J.
name: Babcock, H.M.
name: Claeys, K.C.
name: Weber, D.J.
name: Cheng, V.C.-C.
name: Wiemken, T.L.
name: Talbot, T.R.
name: Akinboyo, I.C.
name: Rock, C.
name: Harris, A.D.
name: Lofgren, E.T.
name: Gohil, S.K.
name: Yassin, M.H.
name: Coffey, K.C.
Publisher: name: NLM (Medline)
Year: 2022

description: This SHEA white paper identifies knowledge gaps and challenges in healthcare epidemiology research related to coronavirus disease 2019 (COVID-19) with a focus on core principles of healthcare epidemiology. These gaps, revealed during the worst phases of the COVID-19 pandemic, are described in 10 sections: epidemiology, outbreak investigation, surveillance, isolation precaution practices, personal protective equipment (PPE), environmental contamination and disinfection, drug and supply shortages, antimicrobial stewardship, healthcare personnel (HCP) occupational safety, and return to work policies. Each section highlights three critical healthcare epidemiology research questions with detailed description provided in supplementary materials. This research agenda calls for translational studies from laboratory-based basic science research to well-designed, large-scale studies and health outcomes research. Research gaps and challenges related to nursing homes and social disparities are included. Collaborations across various disciplines, expertise and across diverse geographic locations will be critical.
Cost of Storing and Handling Grain in Commercial Elevators, 1970-71 and Projections for 1972-73
Creators: name: Schienbein, Allen G.
name: Schienbein, Allen G.
Publisher: name: Unknown
Year: 1972
Subjects: subject: Crop Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Research Methods/ Statistical Methods
subject: Grain elevators
subject: Average costs
subject: Grain handling
subject: Storage projections

description: This report develops handling and storage costs associated with operating 251 commercial grain elevators in 1970-71. Standardized book costs for grain storage were estimated at 8.9 cents per bushel in 1970-71, compared with 6.7 cents in a similar study in 1964-65. Based on 1970-71 replacement value of the elevator's physical plant, the average yearly cost per bushel was 14.9 cents. Projecting storage costs to 1972-73 price levels and volumes shows an increase to 16.3 cents per bushel. In a purely competitive situation, the total space needed to store the anticipated 1972-73 volumes of grain could be obtained at a total cost of 15.5 cents per bushel; 6.5 cents would meet the out-of-pocket or cash expenses for 1972-73. A special study of 30 inland and port terminals shows capital and operating costs for dust control systems averaged 6.39 cents and 1.42 cents per bushel of storage capacity, respectively, and 1.23 and 0.27 cents per bushel of grain handled.
Sonnenfleckenzeichnung Nr. 160.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.07.2010, 06:45, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Three-dimensional multi-site random access photostimulation (3D-MAP)
Creators: name: Waller, L.
name: Adesnik, H.
name: Xue, Y.
name: Pégard, N.
Publisher: name: NLM (Medline)
Year: 2022

description: Optical control of neural ensemble activity is crucial for understanding brain function and disease, yet no technology can achieve optogenetic control of very large numbers of neurons at an extremely fast rate over a large volume. State-of-the-art multiphoton holographic optogenetics requires high-power illumination that only addresses relatively small populations of neurons in parallel. Conversely, one-photon holographic techniques can stimulate more neurons with two to three orders lower power, but with limited resolution or addressable volume. Perhaps most problematically, two-photon holographic optogenetic systems are extremely expensive and sophisticated which has precluded their broader adoption in the neuroscience community. To address this technical gap, we introduce a new one-photon light sculpting technique, three-dimensional multi-site random access photostimulation (3D-MAP), that overcomes these limitations by modulating light dynamically, both in the spatial and in the angular domain at multi-kHz rates. We use 3D-MAP to interrogate neural circuits in 3D and demonstrate simultaneous photostimulation and imaging of dozens of user-selected neurons in the intact mouse brain in vivo with high spatio-temporal resolution. 3D-MAP can be broadly adopted for high-throughput all-optical interrogation of brain circuits owing to its powerful combination of scale, speed, simplicity, and cost.
Cost of Storing and Handling Cotton at Public Storage Facilities, 1970-71, with Projections for 1972-73
Creators: name: Chandler, Whitman M.
name: Ghetti, Joseph L.
name: Chandler, Whitman M.
name: Ghetti, Joseph L.
Publisher: name: Unknown
Year: 1972
Subjects: subject: Crop Production/Industries
subject: Labor and Human Capital
subject: Marketing
subject: FOS: Economics and business
subject: Research Methods/ Statistical Methods
subject: Cotton
subject: costs
subject: storage
subject: projections
subject: competition
subject: warehouses

description: Cotton storage costs for fiscal 1970-71 decreased about 6 percent from 1969-70. Combined storage and handling costs decreased almost 5 percent during the same period. These results are based on analysis of accounting and other data obtained by mail questionnaire from 61 compresses and 27 warehouses. The types of cost given are (1) total cost for all facilities, (2) out-of-pocket cost, which excludes depreciation and interest, (3) total and out-of-pocket cost expected to be incurred in fiscal 1972-73, and (4) short- and long-term competitive rates reflecting the out-of-pocket and total cost of marginal firms, based on projected disappearance and production levels of 10.0 million and 12.1 million bales.
Sonnenfleckenzeichnung Nr. 135.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.06.2010, 07:45, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2010

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
A Uniform Substitution Calculus for Differential Dynamic Logic
Creators: name: Platzer, André
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Programming Languages (cs.PL)
subject: Logic (math.LO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: F.4.1; F.3.1; F.3.2; I.2.3
subject: 03F03, 03B70, 34A38

description: This paper introduces a new proof calculus for differential dynamic logic (dL) that is entirely based on uniform substitution, a proof rule that substitutes a formula for a predicate symbol everywhere. Uniform substitutions make it possible to rely on axioms rather than axiom schemata, substantially simplifying implementations. Instead of nontrivial schema variables and soundness-critical side conditions on the occurrence patterns of variables, the resulting calculus adopts only a finite number of ordinary dL formulas as axioms. The static semantics of differential dynamic logic is captured exclusively in uniform substitutions and bound variable renamings as opposed to being spread in delicate ways across the prover implementation. In addition to sound uniform substitutions, this paper introduces differential forms for differential dynamic logic that make it possible to internalize differential invariants, differential substitutions, and derivations as first-class axioms in dL.