cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cosmopolitan affinities: The question of the nation in Edgeworth, Byron, and Maturin.
Creators: name: Wohlgemut, Esther.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Literature, English.

description: This dissertation is a study of cosmopolitanism in early nineteenth-century Britain, and it approaches cosmopolitanism as an alternative and often overlooked approach to the question of nation in the early nineteenth century. Building out of enlightenment political philosophies such as that of Kant, cosmopolitanism does not mean the absence of national attachment and national limitations but rather involves the co-existence of national demarcations and universal belonging, and in early nineteenth century Britain, it appears alongside romantic nationalism in the struggle to represent the nation. I am interested in how cosmopolitanism in this period offers a non-unified formulation of the nation that stands in contrast to more unified models such as Edmund Burke's which found nationality in, among other things, language, history, blood and geography. The dissertation traces this alternative formulation not only in representative fictions of the late eighteenth and early nineteenth century (e.g. Edgeworth's Irish tales, Byron's Childe Harold and Don Juan, Maturin's Melmoth the Wanderer) but also in British political thought of the period (e.g. Smith's Wealth of Nations, Price's Discourse on the love of our country, and the discourse of the Edinburgh Review). Each chapter examines a different romantic inflection of cosmopolitan ideals and is intended to establish continuities between enlightenment philosophy and the idea of the nation as it unfolds within the British context. The question of balance between trans-national disinterest and national interest is a fundamental one for each of the writers studied in the dissertation, and it has also become paramount in our contemporary struggle to create alternative, non-unified ways of thinking about nationness. The dissertation thus intersects with present debate over the relationship between cosmopolitanism and nationalism, drawing on notions such as Bruce Robbin's "situatedness-in-displacement," Julia Kristeva's "nations without nationalism," Edward Said's "critical thinking," and James Clifford's "pilgrimage."
Three-dimensional nanostructuring of polymer materials by controlled avalanche using femtosecond laser pulses
Creators: name: Rekštyte, Sima
name: Jonušauskas, Linas
name: Žukauskas, Albertas
name: Gervinskas, Gediminas
name: Malinauskas, Mangirdas
name: Juodkazis, Saulius
name: Heisterkamp, Alexander
name: Herman, Peter R.
name: Meunier, Michel
name: Nolte, Stefan
Publisher: name: Swinburne
Year: 2024

description: Abstract not reproduced here by request of the publisher. The text is available from: http://dx.doi.org/10.1117/12.2040971
Umweltbewusstsein und Umweltverhalten junger Menschen
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Umweltbewusstsein
subject: Jugendliche
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Junge Leute betrachten ökologische Fragen nicht losgelöst von sozialen und wirtschaftlichen Fragen. Bei ihnen zeigt sich besonders stark, dass sie Umwelt- und ⁠Klimaschutz⁠ in den Kontext anderer politischer Herausforderungen und der Bewältigung von Zukunftsaufgaben insgesamt stellen. Das Umweltbewusstsein junger Leute zeichnet sich zudem sehr deutlich durch eine globale und langfristige Perspektive aus. Somit kann deren Umweltbewusstsein vielmehr als „Nachhaltigkeitsbewusstsein“ bezeichnet werden.
3567114.pdf
Creators: name: Har-Gil, Hagai
name: Golgher, Lior
name: Israel, Shai
name: Kain, David
name: Cheshnovsky, Ori
name: Parnas, Moshe
name: Blinder, Pablo
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental document
Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis
Creators: name: Hotz, Alrun
name: Oji, Vmzenz
name: Bourrat, Emmanuelle
name: Jonca, Nathalie
name: Mazereeuw-Hautier, Juliette
name: Betz, Regina C.
name: Blume-Peytavi, Ulrike
name: Stieler, Karola
name: Morice-Picard, Fanny
name: Schoenbuchner, Ines
name: Markus, Susanne
name: Schlipf, Nina
name: Fischer, Judith
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Twenty-six families with keratinopathic ichthyoses (epidermolytic ichthyosis, superficial epidermolytic ichthyosis or congenital reticular ichthyosiform erythroderma) were studied. Epidermolytic ichthyosis is caused by mutations in the genes KRT1 or KRT10, mutations in the gene KRT2 lead to superficial epidermolytic ichthyosis, and congenital reticular ichthyosiform erythroderma is caused by frameshift mutations in the genes KRT10 or KRT1, which lead to the phenomenon of revertant mosaicism. In this study mutations were found in KRT1, KRT2 and KRT10, including 7 mutations that are novel pathogenic variants. Novel clinical features found in patients with congenital reticular ichthyosiform erythroderma are described, such as mental retardation, spasticity, facial dysmorphisms, symblepharon and malposition of the 4th toe.
Galaxy and mass assembly (GAMA): The wavelength-dependent sizes and profiles of galaxies revealed by megamorph
Creators: name: Vulcani, Benedetta
name: Bamford, Steven P.
name: Häußler, Boris
name: Vika, Marina
name: Rojas, Alex
name: Agius, Nicola K.
name: Baldry, Ivan
name: Bauer, Amanda E.
name: Brown, Michael J.I.
name: Driver, Simon
name: Graham, Alister
name: Kelvin, Lee S.
name: Liske, Jochen
name: Loveday, Jon
name: Popescu, Cristina C.
name: Robotham, Aaron S.G.
name: Tuffs, Richard J.
Publisher: name: Swinburne
Year: 2024

description: We investigate the relationship between colour and structure within galaxies using a large, volume-limited sample of bright, low-redshift galaxies with optical-near-infrared imaging from the Galaxy AndMass Assembly survey.We fit single-component,wavelength-dependent, elliptical Sérsic models to all passbands simultaneously, using software developed by the MegaMorph project. Dividing our sample by n and colour, the recovered wavelength variations in effective radius (Re) and Sérsic index (n) reveal the internal structure, and hence formation history, of different types of galaxies. All these trends depend on n; some have an additional dependence on galaxy colour. Late-type galaxies (nr < 2.5) show a dramatic increase in Sérsic index with wavelength. This might be a result of their two-component (bulge-disc) nature, though stellar population gradients within each component and dust attenuation are likely to play a role. All galaxies show a substantial decrease in Re with wavelength. This is strongest for early types (nr > 2.5), even though they maintain constant n with wavelength, revealing that ellipticals are a superimposition of different stellar populations associated with multiple collapse and merging events. Processes leading to structures with larger Re must be associated with lower metallicity or younger stellar populations. This appears to rule out the formation of young cores through dissipative gas accretion as an important mechanism in the recent lives of luminous elliptical galaxies.
Velocity measurements by floats and float diffusion.
Creators: name: Kadem, El-Haddi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Civil.

description: For many centuries, streams, rivers and oceans have been used for the disposal of all kinds of man-made wastes and pollutants, of which some are extremely harmful. Studies of the spreading of these effluents require the knowledge of the velocity distribution and current patterns. A practical and alternative way to fixed current meters is the use of tracers such as combined floats or drogues. The purpose of this laboratory investigation is to study the use of combined floats, consisting of a floating disc and a spherical weight, for velocity and discharge measurements and float diffusion. An experimental program was carried out in the hydraulics laboratory and it was found useful to investigate the effect of (i) length and width of the study section, (ii) float size and its depth of immersion and finally (iii) the velocity itself (the magnitude). Because of the limitations involved, three float sizes were selected for which only the disc diameter varied; the sphere diameter, however, was kept constant. When compared to the velocity measured by the Pitot tube, a combination of the smallest float submerged at channel depths above 0.6d in a relatively uniform small section (width and length) was found more appropriate and consequently more accurate. Float diffusion on the other hand was found to depend mainly on the study section length and the float size. Flow velocity was not found to be critical, especially for large floats, and the diffusion width seems to be much diminished when large floats are used.
Expressed support, perceived support and physical ability in chronic pain patients.
Creators: name: Patrick, Louise.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Psychology, Clinical.

description: This study investigated the relationship between social support within the marital context, and physical ability in chronic pain patients. Fifty patients diagnosed with chronic pain and their spouses participated in the study. Each patient was asked to exercise on a stationary bicycle, with his/her spouse present. The interactions between patient and spouse were videorecorded and the spouse's behaviour was rated for the amount of task-related and emotional support expressed. The relationships among the spouse's behaviour, the patient's perception of that behaviour and the patient's physical ability were examined. Marital adjustment, depressive symptomatology and the spouse's perception of the patient's physical limitations were investigated as predictors of expressed and perceived support. Zero-order correlations replicated the previously demonstrated positive relationships among the patient's report of spouse support, pain intensity and marital adjustment. Using hierarchical regression to control for the patient's depressive symptomatology and marital adjustment, it was found that observed spouse support was positively related to the patient's physical ability, accounting for 13% of the variance. When pain severity was also entered into the equation, results indicated that pain intensity was the only significant predictor and was negatively related to the patient's physical ability, accounting for 43% of the variance. No significant predictor of the spouse's expressed support was identified, while the patient's marital adjustment was positively related to his/her perception of support. Descriptive reports by patients of their perception of support during the physical ability task indicated that patients experienced task and emotional support differently. The majority of patients reported that emotional support was experienced as supportive and helpful, but task-related support was not.
Analyse critique de la théorie du FBI sur les tueurs en série.
Creators: name: Duchemin, Mylène.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Psychology, Clinical.

description: Cette recherche s'interesse aux etudes qui ont ete faites sur les tueurs en serie. Nous avons limite notre recherche sur les tueurs en serie masculins americains a partir des annees 1960. Nous avons analyse la theorie du FBI. Deux auteurs ont ete utilises pour cette partie soit Robert K. Ressler et John Douglas, Par la suite, nous avons etudie des theories differentes afin de demontrer que la theorie du FBI, qui est d'approche psychologique, ne peut pas, a elle seule, expliquer les comportements et les motivations des tueurs en serie. Les approches sociales de Eliott Leyton qui traite des inegalites sociales, feministes de Jane Caputi et de Cameron et Frazer qui portent sur la perception des femmes comme victimes et historiques de Philip Jenkins qui s'interesse aux transformations sociales, nous ont permis de demontrer que plusieurs facteurs doivent etre pris en consideration afin de pouvoir expliquer les comportements et les motivations d'un sujet de plus en plus important dans la societe.
Improving Algorithms for Oscillometric Blood Pressure Estimation by Suppressing Breathing Effects
Creators: name: Chen, Silu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Engineering, Electronics and Electrical.

description: Blood pressure estimation by the oscillometry is a practice growing in popularity. Algorithms for blood pressure estimation are diverse, however little effort has been put forth to assess their performance. This thesis first surveys and assesses the algorithms used for oscillometric blood pressure estimation. Of all the known algorithms, the results of this work revealed one procedure which performed the best. These algorithms were evaluated by readings from two trained nurses. Next, we developed algorithms for extracting and suppressing breathing effects on blood pressure estimation. Breathing causes fluctuation in blood pressure and current oscillometric devices do not account for these effects. Extracting breathing signals extends the capabilities of existing oscillometric devices, such as reporting respiratory sinus arrhythmia, without the need for hardware changes. Suppression of these effects is performed by homomorphic and adaptive filtering. Results show improvement in that estimated pressure after suppression was closer to the nurse readings.
3552097.pdf
Creators: name: Chen, Yang
name: Lee, Changhyoup
name: Lu, Liu
name: Liu, Di
name: Wu, Yunkun
name: Feng, Lantian
name: Li, Ming
name: Rockstuhl, Carsten
name: Guo, Guo-Ping
name: Guo, Guang-can
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: supplementary materials
title: Assessment of flood risk for urban and rural communities in Iowa
title: a vulnerability and mitigation analysis framework
titleType: Subtitle
Creators: name: Yildirim, Enes
Publisher: name: University of Iowa
Year: 2022
Subjects: Benefit-Cost Analysis
Flood Event Data Specification
Flood Risk
Flood Vulnerability
Mitigation Assessment
Hydrologic sciences
public abstract

description: Flooding causes fatalities, injuries, and damage to properties, agricultural sites, critical infrastructure, and transportation networks in urban and agricultural communities. The frequency and magnitude of flood events have been increasing around the world. Since disasters involve many aspects of human activities, it is critical to have a comprehensive understanding of flood events and map the risk and vulnerability of flood prone regions to plan, prepare and mitigate the impacts. My research aims to provide a comprehensive specification for defining flood events and understand the risk, vulnerability, and potential mitigation alternatives for communities in Iowa by implementing integrated and scalable mitigation research frameworks.
description: Firstly, I developed a comprehensive set of specifications that embraces multiple aspects of a flood event by conducting an extensive review of the global and national disaster event repositories and the literature. Following this, I performed a large-scale flood risk and vulnerability assessment in urban and agricultural communities in Iowa and identified the most vulnerable regions. I found that federal risk products underestimate the losses for large urban communities. Moreover, I revealed several watersheds with significant potential for mitigation practices to reduce flood risk in the downstream communities. Then, I assessed the historical property buyouts and potential mitigation applications in eastern Iowa communities. I found that the majority of the buyouts can be considered successful considering their benefit-cost ratios. Furthermore, I explored the optimal mitigation option for properties and communities by analyzing multiple flood stages and climate scenarios. The thesis also presents two mitigation research frameworks that examine the benefit-cost ratios and the optimization of mitigation applications on demand.
A case series in patients with enteropathy and granulomatous diseases
Creators: name: Kruis, Tassilo
name: Jöhrens, Korinna
name: Moos, Verena
name: Puls, Imke
name: Siegmund, Britta
name: Daum, Severin
name: Schumann, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Sarcoidosis
subject: Löfgren’s syndrome
subject: Celiac disease
subject: Autoimmune enteropathy
subject: AIE-75
subject: HLA-DR3/DQ2
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Although sarcoidosis and celiac disease are both chronic immunologic disorders involving multiple organ systems, reports about association of diseases in individual patients are sparse. While sarcoidosis is a chronic granulomatous disease presumably reflecting an exaggerated response to an unknown antigen, celiac disease is a T cell-driven disease triggered by ingestion of gluten, a protein composite found in wheat and related grains. Case presentation We present three cases with a longstanding history of sarcoidosis that have been additionally diagnosed with celiac-like enteropathy. In two cases, celiac disease was established applying celiac- specific serology and duodenal histology, while one case was revealed as an AIE-75-positive autoimmune enteropathy. The HLA-DR3/DQ2 haplotype was confirmed in both celiac patients, hence confirming previous data of linkage disequilibrium as a cause for disease association. Remarkably, one celiac patient presented with granulomatous nodulae in the ileum, thus reflecting an intestinal sarcoid manifestation. In contrast the patient with an autoimmune enteropathy, was HLA-DQ9/DQ6-positive, also arguing against CD. Conclusions Associations of sarcoidosis and celiac disease are rare but do occur. Determining the HLA status in patients with complex autoimmune associations might help classifying involved disease entities.
title: Reading ecologies
title: forms of regression in Victorian fiction
titleType: Subtitle
Creators: name: McGann, Maddison
Publisher: name: University of Iowa
Year: 2026
Subjects: subject: Environmental humanities
subject: Nineteenth-century Britain
subject: Print culture
subject: Reception history
subject: Reviewing
subject: Ecology
subject: FOS: Biological sciences

description: Reading Ecologies: Forms of Regression in Victorian Fiction extends recent scholarship in narrative theory and environmental humanities to illuminate how ecological forces shaped the narrative structures of Victorian fiction. Beginning with plague in the early nineteenth century and ending with the British Agricultural Revolution at the fin de siècle, this dissertation reveals how fossil-fueled changes in manufacturing and steam travel, agriculture and infrastructure, were reflected in and refigured through Victorian narrative forms. Driving the action and producing the effects of works such as Mary Shelley’s The Last Man (1826), Charlotte Brontë’s Shirley (1848), Charles Dickens’s Mugby Junction (1866), and Thomas Hardy’s Tess of the d’Urbervilles (1891), these forces—whether viral, industrial, or agricultural—brought the consequences of modern capitalism to bear on nineteenth-century readers.Each of the texts included in this dissertation inhabits dual temporalities, formally as well as thematically, to distinguish between the temporal schemes of two distinct energy economies: flow-based ‘solar’ energy economies and stock-based ‘mineral’ energy economies, the superimposition of which results in not just ecological disruption (rising emissions, resource depletion, atmospheric pollution, and species extinction), but as my chapters will show, narrative disruption (distended syntax, non-linear plotlines, shifting registers, and fragmentary forms). Scaling up from prose structures to global paradigms, I demonstrate how at the smallest register of form, in the complex temporal grammar of their own sentences, these texts offer us one way of encountering the overlapping frames of temporality at stake in this kind of geopolitical historicism. Further, in attending to the contemporaneous reviews of these texts, I reveal a broader reluctance, on the part of reviewers, to confront the harsh realities of ecological degradation and the prevailing narratives that perpetuate it. These reviews provide valuable insights into the cultural and ideological barriers that continue to hinder collective action and policy changes in the face of ecological crises.
title: Complex Project ECA – Extra Containercapaciteit Antwerpen: deelrapport 2. Inschatting van de verandering in SSC met behulp van een multivariaat model
Creators: name: Plancke, Yves
name: Smolders, Sven
name: Vanlede, Joris
Publisher: name: Flanders Hydraulics
Year: 2024

description: Title : WL Rapporten. Waterbouwkundig Laboratorium: Antwerpen.
Volume : 20_091_2
Issue :
Pagination : VI, 20 + 2 p. bijl.
title: The ideal designer
title: how to be the best designer you can in today's world
titleType: Subtitle
Creators: name: Williams, Jake
Publisher: name: University of Iowa
Year: 2023
Subjects: 3D Design
3D Modeling
Digital Design
Fabrication
Furniture Design
public abstract

description: The beginning of the Industrial age redefined what it meant to be a designer. Craftspeople used to make their wares start to finish with each person specializing in making a small sample of specific goods. The implementation of the assembly line no longer required workers to see a project through but rather hone their skills in on one specific production task. This created a massive disconnect between those who come up with the designs, and the workers that physically produce and manufacture those designs. In my opinion that this separation into two camps, the designers, and the fabricators, contributes to the overall chagrin of the design industry. This thesis is about the disconnect and associated benefits of designing products when using modern digital design and hands on fabrication, and how an ideal designer in today’s world must properly utilize both practices to achieve their maximum potential. We will be comparing the overall cost and accessibility of each of these groups and elaborate on the complimentary design elements that each independently excels in. We will also discuss some of the key lessons and takeaways that I have found to be most helpful in completing my design work while attending the University of Iowa during my undergraduate and graduate studies. We will explore examples of virtual renders and physical designs to highlight and contrast where each practice is sub-optimal and how the other discipline can effectively help solve these issues.
Stem cells and beta cell replacement therapy: a prospective health technology assessment study
Creators: name: Wallner, Klemens
name: Pedroza, Rene G.
name: Awotwe, Isaac
name: Piret, James
name: Senior, Peter A.
name: Shapiro, A. M. J.
name: McCabe, Christopher
Publisher: name: BioMed Central
Year: 2018

description: Background: Although current beta cell replacement therapy is effective in stabilizing glycemic control in highly selected patients with refractory type 1 diabetes, many hurdles are inherent to this and other donor-based transplantation methods. One solution could be moving to stem cell-derived transplant tissue. This study investigates a novel stem cell-derived graft and implant technology and explores the circumstances of its cost-effectiveness compared to intensive insulin therapy. Methods: We used a manufacturing optimization model based on work by Simaria et al. to model cost of the stem cell-based transplant doses and integrated its results into a cost-effectiveness model of diabetes treatments. The disease model simulated marginal differences in clinical effects and costs between the new technology and our comparator intensive insulin therapy. The form of beta cell replacement therapy was as a series of retrievable subcutaneous implant devices which protect the enclosed pancreatic progenitors cells from the immune system. This approach was presumed to be as effective as state of the art islet transplantation, aside from immunosuppression drawbacks. We investigated two different cell culture methods and several production and delivery scenarios. Results: We found the likely range of treatment costs for this form of graft tissue for beta cell replacement therapy. Additionally our results show this technology could be cost-effective compared to intensive insulin therapy, at a willingness-to-pay threshold of $100,000 per quality-adjusted life year. However, results also indicate that mass production has by far the best chance of providing affordable graft tissue, while overall there seems to be considerable room for cost reductions. Conclusions: Such a technology can improve treatment access and quality of life for patients through increased graft supply and protection. Stem cell-based implants can be a feasible way of treating a wide range of patients with type 1 diabetes.
Treatment and transport modeling of landfill leachate contaminants in an engineered wetland system.
Creators: name: Sartaj, Majid.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Environmental Sciences.

description: Although an essential micronutrient, boron becomes toxic at concentrations slightly above the optimum range. The use of an engineered wetland system consisting of a peat filter and a surface water wetland for treatment of landfill leachate was investigated. Laboratory tests showed that boron is mainly present in inorganic form. Adsorption of boron by peat was a fast process and virtually complete within 2.5 hours. Drying of peat (at 105°C, 90°C, 75°C, and air drying), pH, temperature, and solution composition had a significant effect on boron adsorption while shaking and solution-to-soil ratio did not have any significant effect on boron adsorption by peat. Also, the presence of other anions such as SO4 -, Cl- or combination of both in synthetic solution made from boric acid had no significant effect on boron adsorption by peat. Maximum adsorption of boron on peat occurred at a pH around 9. Addition of lime, optimum ratio being 1 g lime to a 100 g peat, enhanced boron adsorption capacity of peat by 50--100%. Adsorption of boron decreased with temperature increase. Boron desorption showed hysteresis as only 24% to 45% of adsorbed boron was released into the solution when subjected to desorption test. A second-order design model for adsorption of boron by peat was developed, which incorporates the effect of pH and temperature. Adsorption capacity of peat was directly related to organic matter content and showed a positive effect, i.e. boron adsorption increased with organic matter content increase. Amberlite resin was far superior to peat and other organic material in adsorbing and removing of boron from leachate. Peat also proved to be effective in removing metals such as iron, lead, and zinc from landfill leachate. A new transport code (in Fortran), SOLTRAN, was developed which has the capability of handling non-linear adsorption isotherms. An engineered wetland system consisting of a peat filter followed by a free water surface wetland at Huneault Waste Management landfill, Ontario, was used as a case study. It was demonstrated that peat filter can effectively treat landfill leachate. (Abstract shortened by UMI.)
title: Investigating chemical pollutants at the ‘druggable’ GPCRome
title: a nexus of pollutant toxicity and predictive risk assessment
titleType: Subtitle
Creators: name: Wilkinson, Joshua C.
Publisher: name: University of Iowa
Year: 2024

description: Many synthetic chemicals used in industrial and consumer applications inevitably pollute our food, water, and air. Much evidence has established these chemical pollutants as a global issue with significant ramifications for our health. To assess their risk and prevent the potential harm that results from their exposure, we must understand the activity of pollutants in biological systems. Unfortunately, despite longstanding knowledge that these chemicals can result in adverse effects on human health, critical gaps remain in the underlying biological activity of many.Our work is focused on identifying pollutant activity at the superfamily of G protein-coupled receptors (GPCRs). G protein-coupled receptors (GPCRs) are central mediators for numerous biological processes and have been implicated as targets that convey harmful effects associated with pollutant exposure. However, little effort has been put forth to holistically investigate pollutant activity at the receptors, and their significance remains uncharacterized. Here, we explore high-throughput screening (HTS) resources intended for drug discovery and pharmacology as novel methods to determine the specific activity of pollutants at the human GPCRome. (GPCRs).
description: In this research, we validate a screening methodology and conduct a pilot screen of eight chemical pollutants at a library of 314 GPCRs (the ‘druggable GPCRome’). The main findings from our work identify PCB congeners (52 and 95) as specific and selective agonists for sphingosine-1-phosphate and melatonin receptors (S1PR4 and MNTR1B). To our knowledge, this work is the first report on the GPCR screening resources being applied in this manner and the findings of PCB activity.
title: Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock
title: A Bioinformatics Approach
titleType: Subtitle
Creators: name: Lehmann, Robert
name: Childs, Liam
name: Thomas, Philippe
name: Abreu, Monica
name: Fuhr, Luise
name: Herzel, Hanspeter
name: Leser, Ulf
name: Relógio, Angela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the suprachiasmatic nucleus (SCN) controls peripheral clocks that are present in virtually every body cell. Defective circadian timing is associated with several pathologies such as cancer and metabolic and sleep disorders. To better understand the circadian regulation of cellular processes, we developed a bioinformatics pipeline encompassing the analysis of high-throughput data sets and the exploitation of published knowledge by text-mining. We identified 118 novel potential clock- regulated genes and integrated them into an existing high-quality circadian network, generating the to-date most comprehensive network of circadian regulated genes (NCRG). To validate particular elements in our network, we assessed publicly available ChIP-seq data for BMAL1, REV-ERBα/β and RORα/γ proteins and found strong evidence for circadian regulation of Elavl1, Nme1, Dhx6, Med1 and Rbbp7 all of which are involved in the regulation of tumourigenesis. Furthermore, we identified Ncl and Ddx6, as targets of RORγ and REV-ERBα, β, respectively. Most interestingly, these genes were also reported to be involved in miRNA regulation; in particular, NCL regulates several miRNAs, all involved in cancer aggressiveness. Thus, NCL represents a novel potential link via which the circadian clock, and specifically RORγ, regulates the expression of miRNAs, with particular consequences in breast cancer progression. Our findings bring us one step forward towards a mechanistic understanding of mammalian circadian regulation, and provide further evidence of the influence of circadian deregulation in cancer.
Logistic regression for the modeling of low-dose radiation effects.
Creators: name: Thompson, Gavin Kenneth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Biostatistics.

description: The primary goal of this thesis is to examine statistical procedures that determine if a nonlinear threshold dose effect occurs in cancer incidence in animal experiments. This is to say, does there exist a level of radiation which does not increase the risk of cancer in animals? This question will be explored on data over several species of animals (beagles, rats, and mice) and several different sources of radiation (e.g. radium, or plutonium). Here we consider experiments with several groups of animals at several dose levels In mathematical terms, this thesis will determine if a "knee" fit to a logistic regression models the data better than a simple logistic regression curve. The knee is a non-linear kink in the dose response relationship at a specific dose. If there is evidence to support the knee model hypothesis, it can be interpreted to mean that there is evidence of a threshold effect in the dose response. A secondary goal is to determine if two knees will suffice for data sets of this nature. The motivation behind this goal, is that a two knee model should be able to model both a low dose threshold and a high dose drop-off (due to over exposure to radiation, past the Maximally Tolerated Dose, MTD). Any knees above two will generally only contribute to overfitting of the model. Another goal is to give guidelines on the design of experiments, that will assist researchers in determining if a threshold does in fact exist.
Kooperativ Lehren, Lernen und Arbeiten in den Gesundheitsprofessionen: Das Projekt interTUT
Creators: name: (:Unkn) Unknown
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Lehren
subject: Lernen
subject: Gesundheitsprofession
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung

description: Aktuelle Befunde deuten darauf hin, dass Kompetenzen zur interprofessionellen Zusammenarbeit sowohl das Outcome von Gesundheitsleistungen verbessern, als auch die Patientensicherheit und die Arbeitszufriedenheit der Beteiligten erhöhen können. Dem wird in der Ausbildung von Mediziner/innen sowie der von Therapie- und Pflegeberufen in Deutschland noch zu wenig Rechnung getragen, v.a. auch im internationalen Vergleich mit Ländern im skandinavischen und englischsprachigen Raum. Das Vorhaben, Angehörige der Gesundheitsprofessionen bereits in frühen Phasen ihrer Ausbildung miteinander in Kontakt zu bringen und ihnen gemeinsame Lernräume für interprofessionelle Zusammenarbeit zu eröffnen, stellt an bundesdeutschen (Hoch-)Schulen und in Versorgungseinrichtungen immer noch eine große strukturelle und inhaltliche Herausforderung dar. Um dem zu begegnen, werden im Projekt INTERTUT die an der Charité in den letzten Jahren gesammelten Erfahrungen mit extracurricularen studentischen Tutorien genutzt, um interprofessionelle Basiskompetenzen für die spätere Zusammenarbeit verschiedener Gesundheitsprofessionen gezielt einzuüben. Konkret wurden in dem von Oktober 2013 bis Dezember 2015 durchgeführten Projekt interprofessionelle Lerneinheiten – kurz interTUTs – partizipativ entwickelt, erprobt, evaluiert und nachhaltig implementiert. Teilgenommen haben Studierende der Medizin, der Ergo- und Physiotherapie sowie Auszubildende und Studierende der Gesundheits- und Krankenpflege. Die Lerneinheiten haben die bereits am Lernzentrum der Charité erprobte Form extracurricularer studentischer Tutorien. In einem ersten Schritt wurden zwei Basistutorien entwickelt und angeboten, die im Verlauf als Vorbereitung für weitere, darauf aufbauende Tutorien zu interprofessionellen Kernkompetenzen dienten.
Leitfaden zur umweltfreundlichen öffentlichen Beschaffung: Emissionsarme Putze für den Innenraum
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Öffentliche Beschaffung
subject: Umweltfreundliche Beschaffung
subject: Putz
subject: Innenraumputz
subject: umweltfreundliche öffentlichen Beschaffung
subject: Wirtschaft | Konsum
subject: Gesundheit

description: Innenputze kommen ähnlich wie Wandfarben großflächig in Innenräumen zum Einsatz. Deshalb ist es wichtig, dass die Produkte emissions- und schadstoffarm sind. Aus Gründen des Umwelt- und Gesundheitsschutzes wird nach diesem Leitfaden zum Beispiel der Einsatz biozider Wirkstoffe zur Konservierung ausgeschlossen. Der Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für emissionsarme Putze für den Innenraum (DE-UZ 198, Ausgabe Januar 2019). Quelle: www.umweltbundesamt.de
description: Innenputze kommen ähnlich wie Wandfarben großflächig in Innenräumen zum Einsatz. Deshalb ist es wichtig, dass die Produkte emissions- und schadstoffarm sind. Aus Gründen des Umwelt- und Gesundheitsschutzes wird nach diesem Leitfaden zum Beispiel der Einsatz biozider Wirkstoffe zur Konservierung ausgeschlossen.Der Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für emissionsarme Putze für den Innenraum (DE-UZ 198, Ausgabe Januar 2019).
Is access to content really the new bottleneck: or should we be content about content?
Creators: name: Paterson, Paul
Publisher: name: Swinburne
Year: 2024

description: Exclusive rights to premium content, and other content-related factors, are identified in the Convergence Review Report as potentially powerful impediments to competition in the rapidly converging telecommunications and media sectors. Substantial revisions to existing regulatory arrangements are recommended in the Report to address this threat. However, it is not apparent that these concerns are justified, or that the dramatic institutional changes proposed are warranted. Rather, a number of convergence-related developments in premium content demand, availability, and distribution suggest that any market power bestowed by exclusive access rights in the past may be eroding. This paper highlights these developments. It is concluded that, that taken together, they do indeed have the scope to weaken the threat to competition seen in exclusive content rights. Caution is counselled in proclaiming the prospect of emerging content-related threats to competition, and instituting changes to the regulation of communications competition in Australia, until market evidence is examined more closely.
Gender differences in the enculturation process of new faculty in science.
Creators: name: St-Denis, Natalie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Psychology, Industrial.

description: This study investigates the differences in the enculturation process of new female and male faculty in science. Four subjects (2 females and 2 males) were interviewed over a period of one year during their first year in a tenure-track position in order to collect information on their experiences during the four stages of the enculturation process: (1) the pre-arrival stage; (2) the encounter stage; (3) the adaptation stage; (4) the commitment vs individuation stage. The experiences and feelings between the genders were systematically compared. It appears that there were gender differences with respect to reconciling career and family responsibilities, in setting work priorities, the number and quality of interactions that females and males have with colleagues, the perception on their new setting and work satisfaction. Overall, it would seem that the two female subjects moved towards individuation with respect to the organizational culture within the scientific community. In contrast, it seems that the two male subjects seemed to move towards commitment of the organization. In Phase 2 of the study, four additional female scientists were interviewed in order to explore key enculturation issues for women scientists. The themes explored were: (1) Balancing academe and family life; (2) the need for mentors; (3) a new definition of success; (4) choosing science as a career---successes and regrets. Finally, the study proposes further development with respect to the theoretical model of the enculturation process. Furthermore, a theoretical framework of three female profiles is proposed for the purpose of further investigation.
The development of rapid food safety assessment methods to address the current limitations of food safety assessment methodologies
Creators: name: Tsai, Meng-Hsien
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract
Molecular Biology

description: Foodborne diarrheal diseases remain a leading cause of global illness and death. A significant amount of disease burden is concentrated in low and middle-income countries (LMICs). The emergence of antimicrobial resistance (AMR) bacteria could complicate future diarrheal disease treatments. However, evidence on the risk for child exposure to foodborne enteric bacteria is limited in Kenya. Even when such evidence was available, the current food safety testing methods for detecting safety issues are time-consuming and inaccurate in determining where food safety and AMR steward interventions are needed. To address those gaps, we assessed the performance of species-specific Bacteroides microbial source tracking (MST) markers to determine if they are suitable indicators of enteric pathogen contamination in food. We found that Bacteroides MST markers are unsuitable for indicating enteric pathogen contamination in food due to the low sensitivity between MST markers and pathogen detections. We developed a Salmonella enrichment and real-time polymerase chain reaction (qPCR) pathogen detection protocol that reduced the time needed for food safety assessment and provided a means for quantifying concentrations of viable bacteria. The time shortened 5-hour 37 °C enrichment protocol in peptone water was sufficient for Salmonella detection in milk by culture and qPCR. In addition, successive PCR measurements made qualitative and quantitative assessments of viable Salmonella possible.
description: Last, the AMR research in this dissertation highlighted the need for antibiotic stewardship in the milk supply chain and communities since the qPCR assay has detected resistance genes from Salmonella isolated from milk products and infant food that could express resistance to antimicrobials commonly used toward Kenyan farm animals. Additional molecular-based AMR testing should be conducted on other food products in Kenya to help policymakers design interventions to prevent the proliferation of AMR bacteria.
The effects of an 8-week computerized cognitive training program in older adults: a study protocol for a randomized controlled trial
Creators: name: Ten Brinke, Lisanne F
name: Best, John R
name: Crockett, Rachel A
name: Liu-Ambrose, Teresa
Publisher: name: BioMed Central
Year: 2018

description: Background: Given the world’s aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitive impairment and dementia. As a result, there is much interest in lifestyle approaches. Specifically, complex mental activity, such as cognitive training, may be a promising method to combat cognitive decline in older adults. As such, the industry of commercial computerized cognitive training (CCT) applications has rapidly grown in the last decade. However, the efficacy of these commercial products is largely not established. Moreover, exercise is a recognized strategy for promoting cognitive outcomes in older adults and may augment the efficacy of computerized cognitive training applications. Therefore, we propose a proof-of-concept randomized controlled trial (RCT) to examine the effect of a commercial CCT program in community-dwelling older adults. Methods: An 8-week RCT to examine the effect of a commercial CCT program, alone and preceded by a 15-min brisk walk, on cognitive function and explore the underlying neural mechanisms in adults aged 65–85 years old. Participants will be randomized to one of three intervention groups: 1) Computerized cognitive training (FBT); 2) A 15-min brisk walk followed by computerized cognitive training (Ex-FBT); or 3) A combination of educational classes, sham cognitive training, and balanced and tone exercises (active control, BAT). Participants in all intervention groups will attend three one-hour classes per week over the course of the intervention. Participants will be assessed at baseline, trial completion, and 1-year post study completion (1-year follow-up). Discussion: If results from this study show benefits for cognition at trial completion, CCT programs, alone or in combination with walking, might be a strategy to promote healthy cognitive aging in older adults. In addition, results from the 1-year follow-up measurement could provide important information regarding the long-term benefits of these CCT programs. Trial registration ClinicalTrials.gov Protocol Registration System: NCT02564809; registered September 1, 2015.
3567823.pdf
Creators: name: Giacoumidis, Elias
name: Choudhary, Amol
name: Magi, Eric
name: Marpaung, David
name: Vu, Khu
name: Ma, Pan
name: Choi, Duk-Yong
name: Madden, Stephen
name: Corcoran, Bill
name: Pelusi, Mark
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
An exploration of pilot workload and attention in autonomously piloted fighter aircraft
Creators: name: Thompson, Colton
Publisher: name: University of Iowa
Year: 2022
Subjects: autonomy
aviation
pilot
workload
Artificial intelligence
public abstract

description: Manned-unmanned teaming is set to be the future of air combat. In this environment, a trained artificial intelligence (AI) “pilot” can fly the aircraft while the human pilot focuses on other tasks more suited to the human. Research is currently being done to examine the trust between the human and non-human teammates in the cockpit of a fighter aircraft. This study will focus on the human side of this team, more specifically the operator workload response in different phases of flight during air combat maneuvers (ACM) while an autonomous pilot is in control of the aircraft.
description: In order for the human in the cockpit to effectively perform other tasks while the AI pilot flies the aircraft, the human’s workload state must be at an appropriate level to allow for secondary or tertiary tasks. The goal of this research is to identify phases of ACM which result in elevated or lowered workload responses and use the results therein to better understand human trust in autonomy. In the scenarios presented, each engagement was a one vs. one fight, with no air-to-air missiles allowed: only guns. Several methods are explored, including ECG-derived cognitive workload, a Z-score-based standardization of this workload, and secondary task attentional demand.
description: In this exploration, results will show that workload is relatively stable while the aircraft are laterally separated and pose no threat to one another. At the merge, where the two aircraft pass by one another on a high aspect setup, workload and attentional demand is at its highest. As the fight then progresses, the main drivers of workload and attention are changes in positional advantage; more specifically the speed at which these changes occur. From these results, it is hoped to form a clearer picture of which AI-pilot behaviors can help the pilot more effectively complete necessary tasks while the AI pilot operates the aircraft.