cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Not (Officially) in My Backyard
Creators: name: Jo, Nathanael
name: Vallebueno, Andrea
name: Ouyang, Derek
name: Ho, Daniel E.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: One promising policy approach to addressing housing needs is liberalizing accessory dwelling unit (ADU) development. Yet, understanding the impact of such policy efforts is fundamentally constrained by the inability to quantify and characterize unpermitted ADUs, which may expose homeowners and tenants to legal, financial, and safety risks and confound policy evaluations. We addressed this gap by leveraging computer vision and human annotations to estimate the population of detached ADU constructions in San José (CA). Our contributions are threefold: 1) We estimated the proportion of unpermitted ADU constructions from 2016 to 2020; 2) we describe the demographic, housing market, and parcel characteristics associated with these informal ADUs; and 3) we provide a data set of labeled small buildings, excluding unpermitted detections, for further research. We found that informal ADU construction was substantial—approximately three to four informal units for every formal unit—and more likely in more diverse, dense, and overcrowded neighborhoods. Though our study was limited to analyzing detached ADUs during one time period, we set the stage for further investigations of informal housing across different typologies and over time. Our approach demonstrates the promise of computer vision and human annotations to enable more robust, comprehensive, and reliable understanding of actual—not just permitted—housing units. We urge planners and other policymakers to consider the growth patterns of unpermitted ADUs to more optimally and equitably address housing needs.
¡VAMOS! Vaping among multicultural Orange County students
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: While tobacco remains one of the most preventable causes of cancer and other chronic diseases, public health faces a crisis from the growing use of e-cigarettes. Unfortunately, most studies have been conducted with non-ethnically diverse samples of youth. Furthermore, studies that included larger proportions of ethnically-diverse adolescents failed to explore cultural and community influences. This exploratory pilot study applies youth empowerment theory to the development of the Vaping Among Multicultural Orange County Students (¡VAMOS!) program, that will recruit, train and facilitate of a cohort of n=20 ethnically-diverse youth ages 13-17 years old in a program to understand the influences on youth e-cigarette initiation and use in the Anaheim Union High School District (AUHSD). A two-phase, community-based practice research-informed approach will be used. First, administrators and/or teachers from ten AUHSD schools will be identified and engaged to form the Advisory Board for the study, with the primary role of identifying and nominating youth to apply to the program (Aim 1). During the first year, youth researchers will be trained on e-cigarettes (what they are, how they entice youth, etc), community issues, and research methods (Aim 2). They will also complete a peer ethnography project to inform their understanding of possible community and cultural factors associated with e-cigarette use (Sub-aim 2.1). In the second year, youth researchers will design and implement their own assessment of e-cigarette initiation factors (Sub-aim 2.2), and analyze and present data to the school recruitment committee, students and parents, AUHSD board of trustee members, Anaheim city council members, and other community residents and stakeholders (Aim 3). Changes in ¡VAMOS! youth researcher knowledge, efficacy, and skills will also be assessed. Short-term outcomes include support for the development of a larger youth-driven e-cigarette prevention program, with our long-term goal the institutionalization of the youth curriculum and reductions in e-cigarette use.
Rosa arvensis Huds.
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Rosales
Rosaceae
Rosa
Rosa arvensis

description: Rosa arvensis Huds.
− Secteur San Pedrone, commune de Rusio, à l’W du village, piste montant vers la Punta di l’Ernella, entre Aghiola et Capella, près du replat et un peu à l’E du point coté 1167, fruticée en bord de piste, un individu, 18.7.201 4, Delage, A. cbnc observation et photos; commune de Sant’Andrea-di-Boziu, au SW de Piedilacorte, près du premier tombeau sous l’église paroissiale Sant’Andrea, en surplomb de la route, quelques pieds, 10.6.201 3, Delage, A. & C. Carrasco cbnc observations et photos; bord de la D539, au SW de Caselli, en haut du thalweg de l’affluent rive gauche du Ruisseau de Guado Buja, quelques pieds, 8.7.201 3, Carrasco, C. s.n. (Hb. CBNC); au SE de Campidondico, dans le prolongement de la piste, bord du sentier, dans le thalweg à l’W de Aja Nova, le long d’un vieux mur, un individu, 2.4.201 4, Delage, A. cbnc observations et photos; secteur Rotondu, commune de Casanova, versant E de la Punta di a Gianfena, coteau de Teppe a Felce, un peu au N du lieu-dit, 1130 m, fruticée préforestière en lisière de lariçaie, un individu, 22.7.201 4, Delage, A. cbnc observation.
La station de l’église Sant’Andrea est proche de celle initialement découverte par DESCHÂTRES (Candollea 42: 77, 1987), et c’est d’ailleurs en recherchant, en vain, cette dernière, que la trouvaille a été faite. Les deux autres mentions montrent que l’espèce existe en plusieurs endroits autour de Sant’Andrea-diBoziu, mais toujours en très petit effectif, le plus souvent par individus isolés. Les deux autres stations sont nouvelles pour ce taxon très rare en Corse, qui n’était pas connu jusqu’à présent du secteur Rotondu. L’identité des plantes nous semble bien établie, les fleurs étant synstylées, à grandes fleurs blanches, solitaires, avec des rameaux à port plutôt rampant, et des folioles larges à dents simples.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 137, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Urban Roadway in America: The Amount, Extent, and Value
Creators: name: Guerra, Erick
name: Duranton, Gilles
name: Ma, Xinyu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: We predicted the amount, share, and value of land dedicated to roadways within and across 316 U.S. primary metropolitan statistical areas. Despite the amount and value of land dedicated to roadways, our study provides the first such estimate across a broad range of metropolitan areas. Our basic approach was to estimate roadway widths using a 10% sample of widths provided by the Highway Performance Monitoring System and apply our estimates to the rest of the roadway system. Multiplying estimated widths by segment length and netting out double counting at intersections provided estimates of land area. We also matched roadway segments and areas to existing land value estimates and satellite-based measures of urbanized land. We found that a little less than a quarter of urbanized land—roughly the size of West Virginia—was dedicated to roadway. This land was worth around $4.1 trillion in 2016 and had an annualized value that was higher than the total variable costs of the trucking sector and the total annual federal, state, and local expenditures on roadways. Conducting a back-of-the-envelope cost–benefit analysis, we found that the country likely has too much land dedicated to urban roads. Federal, state, and local agencies dedicate substantial time, money, and resources to providing roadways. Even with relatively generous assumptions and no external costs from driving, however, we estimated that the average cost of expanding roadways exceeded the benefits by a factor of nearly three when accounting for land value. Policymakers should question policies focused on roadway expansion and consider options to reduce the amount of space dedicated to roadway in favor of more housing, offices, and other land uses. In addition to our findings, we provide a novel data set that academics and policymakers can use to draw their own conclusions about the state of America’s urban roadways.
Imperial Youth For A Tobacco-Free Environment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Imperial County Youth for a Tobacco-Free Environment will build a long-term partnership between San Diego State University (SDSU) and Comite Civico del Valle (CCV) to support tobacco-related research. The research will look at questions developed by communities in Imperial County, a rural county on the southern CA border. We will involve residents in the research using an approach called “community science”. CCV has successfully used community science to look at problems such as air quality at a county level. We will build on that experience to involve community residents in research projects that investigate tobacco-related concerns of neighborhoods or communities. The project goals are to describe the characteristics of a partnership that can support tobacco-related community science research, and to determine how effectively community science involves community residents in planning, conducting, and using research to change local rules and policies. The aims of the project are to: (1) create a lasting partnership that will support community-based participatory research; (2) identify effective strategies to involve residents in planning and conducting research to investigate tobacco-related problems they are concerned about; and (3) share results of community science projects with decision-makers to change rules and policies in neighborhoods and communities. In aim #1, we will ask community residents to identify and prioritize tobacco-related concerns. We will use interviews and group discussion to learn about the partnership. In aims #2 and #3, we will pilot the community science framework with CCV’s Youth Environmental Health Internship program, a one-semester program for high school students. Each semester, the group of students will plan and carry out tobacco-related research projects identified by the community. To answer their research questions, students will collect survey data and environmental and/or biological samples to measure direct evidence of the toxic impact of tobacco in the environment; analyze the data; and use the results to prepare messages for the community and reports for local officials to try to influence policy. This project will increase our understanding of community involvement in tobacco-related research and policy change that may be useful to other California communities.
Libraries Are Resilience Hubs
Creators: name: Laurian, Lucie
name: Doyle, Evan
name: Vamanu, Iulian
name: Logsden, Kara
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified

description: We explored the contributions of local public libraries to community resilience in the face of economic hardships, extreme weather events, and the COVID-19 pandemic using a survey of 415 library directors distributed through state library listservs in 13 Midwestern states, community-level census and presidential elections data, and library-specific data from the Institute of Museum and Library Services annual Public Libraries Survey. We found that public libraries provide invaluable resilience-boosting community services. They help patrons find jobs and access social services, often with one-on-one support. They act as daytime shelters during extreme heat and cold events, which is particularly important for unhoused and underhoused individuals. During the COVID-19 pandemic, they innovated to provide delocalized services and information access, such as installing WiFi hotspots. The provision of these essential resilience-boosting services is largely independent from library resources and community contexts and appear grounded in librarians’ ethos. Our research was limited to Midwestern public libraries and thus results are not generalizable to other regions, private, academic, and specialized libraries. We did not explore the possible relationships between local political majorities that could affect local government funding and priorities and local libraries’ funding sources, levels, and services. Beyond collections and information access, public libraries provide many services relevant to community and economic development and to disaster response. In addition, local public libraries act as resilience hubs in the face of economic stressors and extreme weather events, as well as during the COVID-19 pandemic, and are ready, flexible, adaptable, and willing to support patrons in times of need. Planners seeking to enhance community resilience can work with their local public libraries to build disaster preparedness and response capacity.
Salix triandra Linnaeus
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Salicaceae
Salix
Salix triandra

description: Salix triandra L.
− Palasca: vallée de l’Ostriconi, nord-est de l’étang de Cannuta, 5.6.201 4, Crouzet, N. s.n. (Hb. privé).
Cette espèce très rare (RR) forme ici de petites saussaies marécageuses très longuement inondées alternant avec l’aulne glutineux, à l’interface entre les scirpaies-phragmitaies et les cistaies et maquis environnants. Ce taxon n’était pas signalé dans le secteur.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 137, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Anomotodon Arambourg 1952
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Lamniformes
Mitsukurinidae
Anomotodon

description: Genus Anomotodon Arambourg, 1952
Type species
Anomotodon plicatus Arambourg, 1952, Maastrichtian of Morocco.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 30, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
GRAton PEsticides (GRAPE): Exposure potential from groundwater and air in California Wine Country
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Grave concern has emerged in the community of Graton, located in the wine-growing county of Sonoma, regarding nearby agricultural pesticide use on vineyards, and specifically its potential to contaminate the groundwater supplies on which the town’s residents rely for their domestic water use. At the same time, there is widespread concern about high rates of breast cancer, and questions about whether there is a connection between breast cancer incidence and pesticide contamination.

 This pilot project will serve as a reconnaissance effort to see whether agricultural pesticides are making their way into domestic water supplies and to compare any trace pesticides found in water samples and in ambient air samples with pesticides known to have been used nearby.

 Our project will establish a community-academic partnership that combines relevant scientific expertise, local knowledge and connection to the target community, extensive experience in community-based participatory research, and a solid track record of prior collaboration amongst the partners. We will recruit six Graton householders for a study of pesticides found in water samples collected from indoor and outdoor taps and on silicone bands affixed for a month near their homes. Participants will also complete a brief questionnaire regarding their domestic water use, household pesticide use and filtration system, if any. Participants will be selected based on their likely vulnerability to pesticide contamination due to well depth and type, and proximity to agricultural operations. The study will be guided by a Community Advisory Board comprised of Graton residents. A key element of our dissemination plan will be engagement of conventional growers with operations in the vicinity of Graton, with the goal of fostering awareness of agricultural practices that may be contributing to groundwater contamination.

 The project has the potential to inform local policy advocacy efforts, and to foster collaboration with neighbor-growers to address practices that may be contributing to groundwater pollution. The partnership will benefit the community by bringing expertise to help answer their questions about environmental contributors to disease, and will evaluate the efficacy of domestic filtration systems at eliminating pesticides from drinking water supplies.
"Lymphomizing" Treatment of Head and Neck Cancer using Involved Field RT with Chemo-Immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Current standard treatment for most advanced head and neck cancers involves combined chemotherapy and radiation therapy. Newer treatment approaches are incorporating immunotherapy, specifically PD1:PD-L1 checkpoint inhibitors, into the standard treatment paradigm. Standard radiation fields cover both the primary tumor plus "elective" radiation to areas of potential regional spread, especially to lymph nodes, even though many patients do not actually have disease present in the nodes. Large radiation fields result in significant acute and long-term morbidity, particularly difficulty swallowing, which can lead to feeding tube dependence and risk of aspiration. In the setting of concurrent immunotherapy, it is not clear that such large fields are required. For example, in the treatment of lymphoma, successive advances in the quality of systemic therapy have permitted both lower radiation doses and, importantly, smaller field sizes (i.e., Involved Field Radiation Therapy, IFRT), drastically decreasing the morbidity of radiation therapy. Moreover, treatment of healthy nodes with radiation could actually be harmful by interfering with the effectiveness of immunotherapy, which is trying to stimulate the anti-tumor immune response and depends on functional lymph nodes. However, prospective trials are needed to confirm that it is safe to treat head/neck cancer patients with IFRT and that this does not lead to excessively high rates of recurrence, which to our knowledge has not been tested. Therefore we propose to treat a pilot cohort of 12 patients with IFRT (radiation directed only at visible disease on positron emission tomography) plus immunotherapy with standard chemotherapy (tri-weekly cisplatin), and prospectively assess for rates of disease recurrence. Secondly, we will collect novel information on swallowing function using quantitative imaging techniques in collaboration with speech and language pathology, and will collect serial blood specimens for comparison with data from previous trials using standard radiation.
Investigation of microenvironmental changes to the bone marrow after cytotoxic conditioning
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The bone marrow microenvironment, or niche, houses cells, extracellular matrix, and a milieu of factors that help maintain and regulate hematopoietic stem and progenitor cell (HSPC) function in order to produce sufficient hematopoietic cells over the lifetime of an individual. One of the molecules thought to play an important role in HSPC regulation is bimolecular oxygen (O2). In many pathological conditions such as cancers and inflammation, and in therapeutic regimens such as radiotherapy or chemotherapy, bone marrow oxygenation is disrupted. For example, aberrations in bone marrow hypoxia (low oxygen levels) is a known characteristic of acute leukemias including in patients and evidence suggests that hypoxia or signaling through hypoxia inducible factor (Hif-1), a master regulator of the hypoxic response in cells, may induce spontaneous metastasis to the bone marrow and promote tumor colonization in other cancers (e.g., breast cancer). Furthermore, tumor hypoxia remains a significant barrier to radiotherapy, chemotherapy, and immunotherapy in cancer treatment. We previously determined that elevated levels of oxygen (hyperoxia) are found in the bone marrow 3 days after lethal irradiation (9.5 Gy), sublethal irradiation (4.5 Gy), and chemotherapy (busulfan) due to increased blood flow and decrease oxygen consumption. By day 5 after transplantation of whole bone marrow cells, however, the oxygen landscape begins to change with specific locations experiencing extreme hypoxia (<1% oxygen) while other areas still experiencing hyperoxia. How pathologic disruption of bone marrow oxygenation occurs and the role that hypoxia plays in therapeutic efficacy of cancer is not fully understood. In this proposal, we aim to investigate the microenvironmental changes to the niche (e.g., hemodynamics, vascular remodeling, and oxygenation) over time after clinically relevant cytotoxic conditioning regimes used to treat hematologic malignancies. We will directly visualize these changes over time using intravital two-photon microscopy of the mouse bone marrow in both acute myeloid leukemia models and in cancer free controls with the goal of understanding how and when these therapies disrupt the microenvironment. This proposal will provide crucial preliminary data for a future R01 proposal and may also be sufficient for a small manuscript.
Can New Housing Supply Mitigate Displacement and Exclusion?
Creators: name: Chapple, Karen
name: Song, Taesoo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Environmental Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: The housing affordability crisis is exacerbating displacement and exclusion in built-up urban neighborhoods. Although new housing development might help, it faces local opposition. Researchers have struggled to inform this debate because of data challenges, so we constructed a unique database on construction and household-level mobility to determine how development affects displacement and exclusion in the subsequent 5 years in Los Angeles (a typical coastal “hot market” in California) and San Francisco (the extreme “superstar city” case in California). We found that developing new market-rate housing generally helped slightly to alleviate both displacement and exclusion pressures for low-income households in Los Angeles and helped increase in-migration into weaker market neighborhoods in San Francisco. But particularly in the hottest markets, the new market-rate units could fail to spur low- and moderate-income households’ in-migration and exacerbate their out-migration. Likewise, the positive impacts of the new market-rate units may fade over time. Subsidized housing generally mitigated both exclusion and displacement slightly in most markets. Future research should examine long-term effects in a variety of contexts, controlling for the role of housing policies such as rent stabilization. Market-rate housing development may help alleviate rent pressures locally and regionally, but it is not sufficient to address displacement and exclusion at the neighborhood level. Because new production helps to mitigate displacement and exclusion in some contexts but exacerbates it in others, planners need to understand the market and neighborhood context for development. In addition to supporting more market-rate and subsidized housing development through zoning and fiscal tools, planners should implement complementary policies such as housing preservation and tenant protections.
Saxifraga paniculata Mill.
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Saxifragaceae
Saxifraga
Saxifraga paniculata

description: Saxifraga paniculata Mill.
− Capicorsu, commune d’Ogliastru, Monte Cannetu, 1250 m, rochers de la crête, rares exemplaires dans un groupement des Asplenietae trichomanis, 2013, Marzocchi, J.-F. observation.
Cette espèce est nouvelle pour le secteur du Cap Corse. Elle est commune en Corse, mais JEANMONOD & GAMISANS (Fl. Corsica (ed. 2): 395, 2013) l’indiquaient uniquement «du massif de Tenda à celui de Cagna». Nous l’observons dans cette station régulièrement depuis 2009.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 138, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Measuring Transit Equity of an On-Demand Multimodal Transit System
Creators: name: Hwang, Uijeong
name: Lieu, Seung Jae
name: Guan, Hongzhao
name: Dalmeijer, Kevin
name: van Hentenryck, Pascal
name: Guhathakurta, Subhrajit
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Statistics
subject: FOS: Mathematics
subject: Mental Health

description: On-demand transit is attracting the attention of transportation researchers and transit agencies for its potential to solve the first-mile/last-mile problem. Although on-demand transit has been proved to increase transit accessibility significantly, its impact on transit equity and equality has not been addressed. In this study we examined the potential impact of the On-Demand Multimodal Transit System (ODMTS) in Atlanta (GA), on both transit equity and equality compared with the existing transit system. The results showed that ODMTS could have a positive impact on transit equality by reducing the disparity in transit service between neighborhoods close to and far from the existing transit network; however, it may not improve transit equity. This study highlights the fact that improving transit service alone is not enough to create an equitable transportation environment, as accessibility is determined by both transportation and land use. Planners should consider interventions that address both factors, such as transit-oriented developments with affordable housing, to meaningfully tackle the inequities in transit accessibility. An interactive online portal for further exploration of various scenarios of accessibility changes in Atlanta and their impact on equity and equality is available at https://geospatial.gatech.edu/transit-equity.
Synthetic Studies on a FoxO3a Transcription Factor Inhibitor
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic myeloid leukemia (CML) is treated effectively with tyrosine kinase inhibitors (TKI). Post therapy, CML recurrence often derives from dormant, drug resistant CML stem cells. Growth of these cells is thought to be driven by the accumulation of nuclear transcription factor FoxO3a. FoxO3a is also critical for the self-renewal of hematopoietic stem cells (HSCs) and leukemia initiating cells (LICs). The FoxO (forkhead box subclass O) family of proteins normally function as tumor suppressors by inducing cell cycle arrest and apoptosis. The FoxO3a transcription factor is a disordered protein that behaves differently. It has been shown to induce cancer cell invasion and metastases as well as drug resistance. Therapies able to eliminate CML stem cells not targeted by TKIs would be highly valuable. The peptidomimetic natural product JBIR-141 was recently discovered as an inhibitor of FoxO3a induced transcriptional activity. It is potently cytotoxic towards SKOV-3, MESO-1 and Jurkat cells in vitro (IC50 = 12, 90 and 4 nM, respectively). The natural abundance of the molecule is low, it has not been synthesized and its molecular mode of action is unknown. The goal of this project is to develop a short, modular synthesis JBIR-141 and thoroughly probe its structure activity relationships. The reactivity and stability of its oxazoline, nitrosamine and acyl tetramate motifs will be explored. We speculate the natural product is a membrane permeant pro-form of an active substance generated intracellularly. Our experiments will address that possibility and set the stage for key collaborative studies of its molecular mode of action and its potential as a new, targeted therapeutic.
Expanding Affordable Middle Housing Options in Single-Family Neighborhoods
Creators: name: Dong, Hongwei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: By examining the Residential Infill Project (RIP) in Portland (OR), this study addressed the ongoing debate on single-family zoning reform, focusing on the effectiveness of legalizing middle housing in expanding housing options in single-family neighborhoods. The analysis revealed a substantial increase in the proportion of middle housing in residential developments in single-family zones, from 13.4% before the RIP implementation to 44.7% in the 2 years after RIP’s adoption. Almost 40% of these post-RIP middle housing permit units were replacements for existing homes. Compared with single-family housing developments, middle housing projects were more likely to be in neighborhoods with greater density, better walkability, and lower income. The RIP broadened middle housing accessibility by allowing their development on non-corner lots, at greater distances to the city center, and in medium-density single-family zones. The RIP’s approach to regulating development density and building size significantly reduced the average size of middle housing units in single-family zones to less than half that of single-family homes. Given the strong correlation between home sizes and prices, it seems reasonable to infer that middle housing units have become considerably more affordable since the enactment of the RIP. Eliminating single-family zoning represents an initial step in expanding housing options in single-family neighborhoods. More comprehensive zoning reforms are essential for meaningful improvements in housing affordability and diversity. Cities must reassess and amend zoning codes, particularly development standards, to foster innovation in middle housing development and encourage developers to build smaller homes to lower housing costs.
Ctenopelma tomentosum
Creators: name: Sun, Shu-Ping
name: Sheng, Mao-Ling
name: Gao, Chun
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ctenopelma
Ctenopelma tomentosum

description: Ctenopelma tomentosum (Desvignes, 1856)
Fig. 60
Campoplex tomentosus Desvignes, 1856: 100.
Material examined
CHINA – Liaoning Prov. • 2 ♀♀; Kuandian, Baishilazi National Natural Reserve; alt. 400 m, 1–3 Jun. 2001; Mao-Ling Sheng leg. • 1 ♀; Kuandian; 16 Jul. 2007; Mao-Ling Sheng leg. • 1 ♀; Kuandian; 16 Jun. 2017; Tao Li leg. • 1 ♀; Qianshan; 15 Jun. 2004; Mao-Ling Sheng leg. • 1 ♀; Xinbin; 8 Jul. 2005; Mao-Ling Sheng leg. • 1 ♀; Xinbin; 23 Jul. 2006; interception trap • 2 ♀♀; Xinbin; 8 Jul.–26 Aug. 2009; interception trap • 1 ♀; Benxi; 15 Jul. 2015; reared from larva ‘silk chamber’ of Neurotoma sibirica Gussakovskij, 1935 by Mao-Ling Sheng • 5 ♀♀; Benxi; 13 Jun. 2017; reared from larva ‘silk chamber’ of N. sibirica by Mao-Ling Sheng and Tao Li • 1 ♀; Benxi; 20 Jun. 2018; reared from larva’s ‘silk chamber’ of N. sibirica by Tao Li • 1 ♀; Haicheng; 11 Jul. 2015; Tao Li leg. – Heilongjiang Prov. • 1 ♀; Chaihe; 21 Jun. 2004; Mao-Ling Sheng leg. – Jilin Prov. • 1 ♀; Changbaishan National Natural Reserve; alt. 1870 m; 23 Jul. 2008; Mao-Ling Sheng leg.
Host
Neurotoma sibirica Gussakovskij, 1935.
Host foodplant
Sorbaria sorbifolia (L.) A.Braun.
Differential diagnosis
In light of the revision by Kasparyan (2004), three species from China, C. melanothoracicum Sheng, 2009, C. rufiscentis Sheng, 2009, and C. tomentosum Desvignes, 1856, belong to the C. tomentosum subgroup, and can be distinguished by the characters given in Table 1.
description: Published as part of Sun, Shu-Ping, Sheng, Mao-Ling & Gao, Chun, 2019, The species of Ctenopelma Holmgren (Hymenoptera, Ichneumonidae) from China, pp. 1-31 in European Journal of Taxonomy 545 on page 28, DOI: 10.5852/ejt.2019.545, http://zenodo.org/record/3382721
Odontites corsicus G. Don
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Orobanchaceae
Odontites
Odontites corsicus

description: Odontites corsicus (Loisel.) G. Don
− Secteur Tenda, au NE du Monte Reghja di Pozzu [42°32,718’N 9°13,137’E], fruticées naine du Berberido-Genistetum, 1300 m, Gamisans, J., L. Hugot & J. Petit observations.
Cette espèce peu fréquente n’était pas signalée dans le massif de Tenda (JEANMONOD & GAMISANS, Compl. Prodr. Fl. Corse, Scrophulariaceae: 104, 1992; JEANMONOD & GAMISANS, Fl. Corsica (ed. 2): 684, 2013).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 138, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
AN EXAMINATION OF INDOOR AIR QUALITY IN RESIDENTIAL HOMES USING FINE-SCALE TEMPORAL MEASUREMENTS AND FUTURE CLIMATE MODEL SIMULATIONS
Creators: name: Lima, Nathan
Publisher: name: Washington State University
Year: 2022
Subjects: Architectural Engineering

description: Poor air quality is considered to be one of the leading causes of global non-communicable disease and mortality. People in the United States spend 87% of their time in enclosed buildings and 69% of that time is spent in their residence. A building's envelope filters pollutants, such as particulate matter (PM) and ozone (O3), as air infiltrates into a building. The indoor environment is also directly affected by indoor sources due to outgassing from indoor materials or due to activities of the occupants such as cooking or cleaning. The outdoor environment around a building is in a constant state of change due to the diurnal cycle caused by solar radiation and on longer time scales caused by changing weather and climate. Therefore, it is important to understand the impacts that could arise from a changing climate. The CONTAM computer model is used to simulate indoor air quality of both fine-scale temporal measured test homes as well as representative U.S. building stock homes. It was found that CONTAM can closely simulate fine-scale temporal measured homes mean concentrations. The process and methodology used from the EPA STAR test homes was applied to simulate representative U.S. building stock homes from three 10-year periods centered on 2000, 2050 and 2090. It was found that the impacts due to climate change on IAQ are very location and home dependent, but tight homes with controllable outdoor air supply system have more to mitigate the effects.
Striatolamia Glikman 1964
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Lamniformes
Odontaspididae
Striatolamia

description: Genus Striatolamia Glikman, 1964
Type species
Otodus macrotus Agassiz, 1843, Eocene, France.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 32, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
New mouse model of immunosuppressive TGF-beta function
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Non-small cell lung cancer (NSCLC) kills more people in the US than any other cancer. Immune checkpoint inhibitors alone or in combination with chemotherapy in patients with advanced disease has improved survival in numerous studies. However, the majority of patients progress within one year and only a small minority of patients with metastatic disease have long term survival. Thus, there remains an urgent unmet need for novel therapeutic approaches to improve outcomes for patients who have cancer refractory to FDA approved immune checkpoint therapies.

 The TGF-b signaling pathway has broad effects on the tumor immune environment (TME) that could contribute to resistance to immunotherapy. Extensive preclinical studies indicate that TGF-b establishes an immunosuppressive TME. Recent preclinical studies have demonstrated that inhibiting TGF-b signaling restored tumor response to checkpoint inhibition in mice. However, the ultimate utility of targeting TGF-b is limited by toxicities, which have been documented in rodents, primates and humans using global TGF-b inhibitors.

 It would be a highly significant advance to establish the mechanistic basis of TGF-b mediated immunosuppression to understand how to most efficaciously target TGF-b function in NSCLC and other cancers. Such mechanistic understanding could lead to both more selective inhibition of TGF-b function, and limit risk of toxicity. We have found that increased selectivity can be achieved by focusing on TGF-b activation, since TGF-b is expressed in a latent form (L-TGF-b) complex that must be activated in order to function. Using a structural biologic approach, we have proposed a new model of TGF-b activation where TGF-b signaling occurs within the L-TGF-b complex without release and diffusion of TGF-b. This model predicts that within the tumor microenvironment that tumor cells can activate TGF-b signaling in contacting immune cells. This mechanism provides a precise mechanism of TGF-b activation to target for immunotherapeutic benefit. Here we will establish a genetic mouse model where TGF-b can only be activated and signal by this highly specific mechanism. This model will be used to establish the relevance of this TGF-b activation mechanism to lung cancer immune evasion and to establish methodologies to more precisely and efficaciously target it.
Verbascum conocarpum subsp. conocarpum
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Scrophulariaceae
Verbascum
Verbascum conocarpum
Verbascum conocarpum moris subsp. conocarpum

description: Verbascum conocarpum Moris subsp. conocarpum
− Bonifacio, carrière de blocs granitiques peu au nord de la Santa Réparata, point côté 109, 28.4.201 3, une quinzaine d’individus, Le Driant, F. observation et photos; Nord-Ouest de Bonifacio, bord de la route N 198 avant l’embranchement de la D60, au niveau de la fontaine de Ferracu, abords rudéraux et sablonneux, 85 m, 2.5.199 8, Alphand, J. s.n. (Hb. privé).
Taxon très rare, contrairement au subsp. conradiae Jeanm., et connu uniquement du sud de l’île. Il avait été signalé autrefois à la Trinité (MURBECK, Acta Univ. Lund 29, 1933) et récolté un peu plus récemment (1981) sous Bitalza par Deschâtres (JEANMONOD & GAMISANS, Compl. Prodr. Fl. Corse, Scrophulariaceae: 155, 1992). Cette mention confirme sa présence actuelle dans le sud de l’île. Dans la première station, les plantes avaient des fleurs à étamines toutes réniformes et à pilosité violette. Les capsules étaient nettement coniques. Elles étaient en compagnie d’ Alkanna lutea (+++) et de Vicia villosa subsp. elegantissima (++).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 138, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Breast health and the Environment among Latinas in Los Angeles (BELLA) Study
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Background: Los Angeles, California is home to the largest urban oil field in the country where oil drilling happens very close to where people live, work, study and play. However, there have been few studies to assess impact to nearby residents. In South LA, the low-income Latinx communities have raised concerns regarding oil drilling. Esperanza Community Housing and University of Southern California have formed the Breast health and the Environment among Latinas in Los Angeles (BELLA) study to assess the impacts of oil drilling on women’s breast cancer risk and inform action.

 Hypothesis: We hypothesize that living near urban oil production is a) associated with higher concentration of oil-related toxic metals in women’s bodies and b) associated with higher breast density, a risk factor for breast cancer.

 Methods: Esperanza and USC will continue a community steering committee to oversee the research and build a cadre of community health workers trained to address environmental exposures, disparities and breast health. We will collect recent mammograms from 400 women to compare breast density among Latina women in South LA living near and farther away from active oil sites. We will collect toenail clippings from each participant to assess exposure to multiple metals, including oil-related metal mixtures. We will relate living near oil wells and having more oil-related exposure with breast density. Finally, we will develop bilingual infographics to communicate the findings.

 Innovative elements/potential impact: This study will be the first of its kind to collect data on breast health in an environmental justice community impacted by oil drilling. We will address an understudied exposure and serve as a model to increase the scientific understanding of the association between oil extraction and breast cancer in a community setting using a well-studied marker (breast density) of breast cancer risk. We address a key community health concern and build upon existing infrastructure of community health workers and breast cancer prevention programs within this community. The study will increase training on scientific methods and develop engagement tools that can serve as a model for other communities. The data will inform a larger campaign to address environmental and health protections of communities living adjacent to oil drilling sites in CA.
Control of Cell Fate Commitment by the Histone Chaperone CAF-1
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: During normal homeostasis mature cells are sustained by their stem and progenitor cells. This process involves a delicate balance between proliferation and differentiation when cells become progressively committed. Cancer arises when this balance is perturbed resulting in a deviation from the normal differentiation and uncontrolled proliferation. How cell fate commitment is restricted during normal homeostasis is largely unknown. Understanding the mechanisms that control this process will shed light on how cell identity is maintained and how it is reprogrammed in cancer. We have previously uncovered a role for the chromatin assembly factor complex CAF-1 in safeguarding cell identity during cellular reprogramming. Mechanistically, we discovered that the loss of CAF-1 results in increasing enhancer elements accessibility to the ectopically expressed transcription factors and therefore facilitating cell fate change. However, how CAF-1 affects cell fate commitment during normal homeostasis is poorly understood. Here we propose to investigate the role of CAF-1 during granulocyte macrophage progenitors (GMPs) differentiation. GMPs must replenish billions of terminally-differentiated neutrophils daily under homeostatic conditions and thus presents an ideal platform to study the mechanisms that restrict cell fate commitment. Our preliminary results demonstrate that acute CAF-1 suppression in GMPs triggers their rapid growth arrest and differentiation into neutrophils. Unexpectedly, single cell RNA-seq analysis of CAF-1 depleted GMPs revealed concomitant activation of megakaryocytes and erythroid transcriptional signatures resulting in a mixed unstable cellular state. How CAF-1 normally restricts GMPs differentiation into neutrophils is unknown. Here we propose to dissect the mechanisms by which CAF-1 restricts lineage choice and prevent alternate cell fate change by (1) Characterize chromatin accessibility upon CAF-1 loss to functionally dissect the role of key transcription factors that instruct alternate cell fate change during myeloid differentiation. (2) Interrogate whether the resulting unstable cell state can be reprogrammed to commit down a specific differentiation path by manipulating signaling and transcriptional pathways. These studies will shed light on how CAF-1 control the activity of lineage specific transcription factors and signaling molecules.
Veronica filiformis Sm.
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Plantaginaceae
Veronica
Veronica filiformis

description: Veronica filiformis Sm.
− Ponte Leccia, à proximité de la voie ferrée, 195 m, quelques pieds, 15.5.201 3, Alphand, J. observation; Corte, près de l’université, 400 m, et près de la gare, 395 m, nombreux pieds, pelouses ouvertes, 16.5.201 2, Alphand, J. s.n. (Hb. privé); cimetière de Ghisoni, 660 m, quelques pieds, 16.5.201 2, Alphand, J. observation.
Taxon nouveau pour la Corse. L’arrivée de cette espèce ouest-asiatique bien installée en Europe tempérée mais encore rare en France méditerranéenne continentale (TISON et al., Fl. France Médit. Continent.: 1348, 2014) était attendue. Au vu de ces récoltes et observations, elle est déjà bien installée dans l’île et sa naturalisation ne fait guère de doute.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 138, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895