cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Affine Extensions of loops
Creators: name: Figula, Agota
name: Strabach, Karl
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20N05, 51F25, 12D15, 51N30, 51M05

description: We show a simple geometric procedure for an extension of a loop realized as the image $Σ^{\ast}$ of a sharply transitive section in a subgroup $G^{\ast}$ of the projective linear group $PGL(n-1, \mathbb K)$ to a loop realized as the image of a sharply transitive section in a group $Δ=T' \rtimes C$ of affinities of the $n$-dimensional space ${\cal A}_n=\mathbb K^n$ over a commutative field $\mathbb K$. We desire that $T'$ is a large subgroup of affine translations and that $α(C)=G^{\ast}$ holds for the canonical homomorphism $α:GL(n,\mathbb K) \to PGL(n, \mathbb K)$. We demonstrate that our construction successfully can be applied to sharply transitive sections in unitary and orthogonal groups $SU_{p_2}(n,F)$ of positive index $p_2$ over ordered pythagorean $n$-real fields $F$.
title: Screening for blunt cerebrovascular injury (BCVI) by two-phased whole body CT (WBCT) after acute blunt trauma using modified Denver criteria: a review of 373 cases
Creators: name: Varjonen, Elina
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Arteries / Aorta
subject: Emergency
subject: Trauma
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Trauma

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The overall incidence of blunt cerebrovascular injury (BCVI) in blunt trauma is reported to be 1 - 1.5 %, and increasing to 2.7 % with an ISS (Injury Severity Score) above 16[1]. Screening based on Denver criteria yields an incidence of up to 5.4...
3D Printing of Food: From Earth to Space, Implications and Challenges
Creators: name: Koh, Justin
name: Abdeljelil, Nissem
name: del Carmen Alvarado Navarrete, Mónica
name: González, Hernan
name: Saeed, Rahma
name: Baxter, Katherine
name: Namukwambi, Rauna
name: Carvil, Phil
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Biochemical and Biomolecular Engineering
subject: Agriculture
subject: Biomaterials
subject: Molecular, Genetic, and Biochemical Nutrition
subject: Nutrition
subject: Life Sciences
subject: Other Chemical Engineering
subject: Other Nutrition
subject: Biological Engineering
subject: Engineering
subject: Aerospace Engineering
subject: FOS: Mechanical engineering
subject: Biomedical Engineering and Bioengineering
subject: Chemical Engineering
subject: FOS: Chemical engineering

description: Systematic review investigating 3D-printing technologies for food production, for space and on Earth.
Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer
Creators: name: Fang, Fang
name: Dumitru, Raluca
name: Gomez, Nicholas C.
name: Hepperla, Austin J.
name: Davis, Ian J.
name: Simon, Jeremy M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown. We explored chromatin accessibility in embryonic and multipotent stem cells and unexpectedly identified widespread chromatin accessibility at repetitive elements. Integrating genomic and biochemical approaches, we demonstrate that these sites of increased accessibility are associated with well-positioned nucleosomes marked by distinct histone modifications. Differentiation is accompanied by chromatin remodeling at repetitive elements associated with altered expression of genes in relevant developmental pathways. Remarkably, we found that the chromatin environment of Ewing sarcoma, a mesenchymally derived tumor, is shared with primary mesenchymal stem cells (MSCs). Accessibility at repetitive elements in MSCs offers a permissive environment that is exploited by the critical oncogene responsible for this cancer. Our data demonstrate that stem cells harbor a unique chromatin landscape characterized by accessibility at repetitive elements, a feature associated with differentiation and oncogenesis.
Exotic see-saw mechanism for neutrinos and leptogenesis in a Pati-Salam model
Creators: name: Addazi, Andrea
name: Bianchi, Massimo
name: Ricciardi, Giulia
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss non-perturbative corrections to the neutrino sector, in the context of a D-brane Pati-Salam-like model, that can be obtained as a simple alternative to $SO(10)$ GUT's in theories with open and unoriented strings. In such D-brane models, exotic stringy instantons can correct the right-handed neutrino mass matrix in a calculable way, thus affecting mass hierarchies and modifying the see-saw mechanism to what we name exotic see-saw. For a wide range of parameters, a compact spectrum of right-handed neutrino masses can occur that gives rise to a predictive scenario for low energy observables. This model also provides a viable mechanism for Baryon Asymmetry in the Universe (BAU) through leptogenesis. Finally, a Majorana mass for the neutron is naturally predicted in the model, leading to potentially testable neutron-antineutron oscillations. Combined measurements in neutrino and neutron-antineutron sectors could provide precious informations on physics at the quantum gravity scale.
description: 35 pages, 2 figures, matches the journal version
Detailed analysis of the Spiderweb proto-ICM
Creators: name: Lepore, Marika
Publisher: name: Zenodo
Year: 2023

description: We present the detailed analysis of the diffuse emission around the Spiderweb Galaxy at z=2.16 using a deep Chandra observation.
 Our work mainly consists in a detailed analysis of the surface brightness of the spiderweb galaxy within a distance of 110 kpc from the central radio source. Although the low S/N of the X-ray data, we actually found that the X-ray expected emission shows significant asymmetries. Interestingly, the detected asymmetry is spatially consistent with the
 Sunyaev-Zeldovich signal measured with ALMA by Di Mascolo et al., 2022 in the Spiderweb field.
 From the combination of the X-ray analysis and Sunyaev-Zeldovich effect analysis, we will eventually confirm the presence of this asymmetric structure and obtain the properties of the proto-ICM, in order to investigate the thermodynamics and heating mechanisms of hot baryons.
Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/ let-7  miRNA-Dependent Pathway in Adult Mammalian Retinas
Creators: name: Qiu, Suo
name: Schaffer, David V.
name: Yao, Kai
name: Snider, William D.
name: Flannery, John G.
name: Chen, Bo
name: Tian, Lin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as they do not spontaneously re-enter the cell cycle unless the retina is injured. Here, we show that gene transfer of β-catenin in adult mouse retinas activates Wnt signaling and MG proliferation without retinal injury. Upstream of Wnt, deletion of GSK3β stabilizes β-catenin and activates MG proliferation. Downstream of Wnt, β-catenin binds to the Lin28 promoter and activates transcription. Deletion of Lin28 abolishes β-catenin-mediated effects on MG proliferation, and Lin28 gene transfer stimulates MG proliferation. We further demonstrate that let-7 miRNAs are critically involved in Wnt/Lin28-regulated MG proliferation. Intriguingly, a subset of cell-cycle-reactivated MGs express markers for amacrine cells. Together, these results reveal a key role of Wnt-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of MGs in the adult mammalian retina.
title: USPIO-labeling in M1 and M2 macrophage population: an in vitro MR study
Creators: name: Zini, Chiara
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Molecular imaging
subject: MR
subject: Experimental investigations
subject: Inflammation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: There is considerable interest in the development of strategies that would enable non-invasive clinical cell tracking to determine the distribution of particular cells within the human body. Magnetic resonance imaging (MRI) seems to be ideal for...
title: Single-session combined radiofrequency ablation and transarterial chemoembolisation in the treatment of hepatocellular carcinoma
Creators: name: Gabr, Ahmed
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional non-vascular
subject: Gastrointestinal tract
subject: Liver
subject: Catheter arteriography
subject: Ablation procedures
subject: Chemoembolisation
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The efficacy of locoregional treatment in small hepatocellular carcinoma (HCC) is comparable to surgical outcomes 1 . However, both medium-sized and large tumors remain a challenge with less robust outcomes. In the current study, we used a...
title: The use of secondary lead rubber protection in paediatric extremity radiographic examinations
Creators: name: England, Andrew
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Radioprotection / Radiation dose
subject: Professional issues
subject: Conventional radiography
subject: Radiation safety

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The use of diagnostic X-rays are accepted to provided huge benefits to patients, however, their use involves a small risk of developing cancer (Parkin & Darby, 2011). Where possible standard radiation protection devicese.g. lead rubber aprons should...
Prior Distributions for a Bayesian Model-Averaged Meta-Analysis of Standardized Mean Differences: An Empirical Assessment Using the Cochrane Database of Systematic Reviews [PREREGISTERED ANALYSIS PLAN]
Creators: name: Timmers, Bram
name: Wagenmakers, Eric-Jan
name: Gronau, Quentin
name: Bartoš, František
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Statistics and Probability
subject: Physical Sciences and Mathematics
subject: Medicine and Health Sciences

description: We outline a Bayesian model-averaged meta-analysis for standardized mean difference effect sizes that can be used to quantify evidence for both treatment effectiveness δ and across-study heterogeneity τ. To inform the choice of prior distributions for the model parameters we used 50\% of the Cochrane Database of Systematic Reviews to specify rival prior distributions for δ and τ, ranging from default to informative. The relative predictive performance of the competing models and rival prior distributions will be assessed using the remaining 50% of the Cochrane Database. The outcome of the predictive assessment may help guide the specification of prior distributions in future Bayesian meta-analyses of continuous outcomes.
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Creators: name: Gao, Xiao-Bing
name: Tebbenkamp, Andrew T.N.
name: Pletikos, Mihovil
name: Gao, Tianliuyun
name: Mlakar, Jernej
name: Varela, Luis
name: Pochareddy, Sirisha
name: Liu, Fuchen
name: Li, Zhen
name: Li, Mingfeng
name: Zhang, Yalan
name: Testen, Anze
name: Popovic, Mara
name: Bichsel, Candace
name: Dell'Anno, Maria Teresa
name: Gulden, Forrest O.
name: Anton,
name: Kaczmarek, Leonard K.
name: Strittmatter, Stephen M.
name: Szigeti-Buck, Klara
name: Flamand, Marie
name: Lindenbach, Brett D.
name: Lisgo, Steven
name: Han, Wenqi
name: Horvath, Tamas L.
name: Nakagawa, Naoki
name: Sestan, Nenad
name: Onorati, Marco
name: Zhu, Ying
name: Sousa, André M.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Graphical Abstract Highlights d Derivation of human neocortical and spinal cord neuroepithelial stem (NES) cells d Zika virus (ZIKV) infects NES cells and radial glia, impairing mitosis and survival d ZIKV induces mitochondrial sequestration of centrosomal phospho-TBK1 d Nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death In Brief Onorati et al. establish neuroepithelial stem (NES) cells as a model for studying human neurodevelopment and ZIKV-induced microcephaly. Together with analyses in human brain slices and microcephalic human fetal tissue, they find that ZIKV predominantly infects NES and radial glial cells, reveal a pivotal role for pTBK1, and find that nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death.
On the shadow moments of apparently infinite-mean phenomena
Creators: name: Taleb, Nassim Nicholas
name: Cirillo, Pasquale
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We propose an approach to compute the conditional moments of fat-tailed phenomena that, only looking at data, could be mistakenly considered as having infinite mean. This type of problems manifests itself when a random variable Y has a heavy- tailed distribution with an extremely wide yet bounded support. We introduce the concept of dual distribution, by means of a log-transformation that removes the upper bound. The tail of the dual distribution can then be studied using extreme value theory, without making excessive parametric assumptions, and the estimates one obtains can be used to study the original distribution and compute its moments by reverting the log- transformation. The central difference between our approach and a simple truncation is in the smoothness of the transformation between the original and the dual distribution, allowing use of extreme value theory. War casualties, operational risk, environment blight, complex networks and many other econophysics phenomena are possible fields of application.
title: Right ventricle function: comparison of two MR segmentation methods and its correlation with echocardiography
Creators: name: Sánchez Paniagua, Inés
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: MR
subject: Echocardiography
subject: Comparative studies
subject: Segmentation
subject: Diagnostic procedure
subject: Haemodynamics / Flow dynamics
subject: Hyperplasia / Hypertrophy
subject: Motility

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Cardiac MR (CRM) is the gold-standard imaging technique for the study of the ventricles as it can provide both quantitative and qualitative information regarding the anatomy and function of both the right and left ventricles. Therefore, it is now an...
Mapping gravitational-wave backgrounds in modified theories of gravity using pulsar timing arrays
Creators: name: Gair, Jonathan R.
name: Romano, Joseph D.
name: Taylor, Stephen R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We extend our previous work on applying CMB techniques to the mapping of gravitational-wave backgrounds to backgrounds which have non-GR polarisations. Our analysis and results are presented in the context of pulsar-timing array observations, but the overarching methods are general, and can be easily applied to LIGO or eLISA observations using appropriately modified response functions. Analytic expressions for the pulsar-timing response to gravitational waves with non-GR polarisation are given for each mode of a spin-weighted spherical-harmonic decomposition of the background, which permit the signal to be mapped across the sky to any desired resolution. We also derive the pulsar-timing overlap reduction functions for the various non-GR polarisations, finding analytic forms for anisotropic backgrounds with scalar-transverse ("breathing") and vector-longitudinal polarisations, and a semi-analytic form for scalar-longitudinal backgrounds. Our results indicate that pulsar-timing observations will be completely insensitive to scalar-transverse mode anisotropies in the polarisation amplitude beyond dipole, and anisotropies in the power beyond quadrupole. Analogously to our previous findings that pulsar-timing observations lack sensitivity to tensor-curl modes for a transverse-traceless tensor background, we also find insensitivity to vector-curl modes for a vector-longitudinal background.
description: 35 pages, 8 figures, submitted to Phys. Rev. D
Gender Socialization in Contemporary American Culture
Creators: name: Wright, Drew
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: American culture
subject: attitudes toward gender
subject: child development
subject: clothing
subject: contemporary culture
subject: developmental psychology
subject: dyads
subject: egalitarian child rearing
subject: feminine
subject: feminism
subject: gender
subject: gender development
subject: gender role attitudes
subject: gender roles
subject: gender stereotypes
subject: masculine
subject: room decor
subject: toys
subject: traditional child rearing
subject: zoom

description: Parents are considered to be the most influential models of gender roles and stereotypes. Children model the behaviors that they see demonstrated by their parents or associated with their gender. In this study, we are interested in parents’ and children’s preferences for different types of items marketed for boys, girls, or both boys and girls. We will send a survey for parents to complete on their own (~15 minutes) and then schedule a ~10-15 minute zoom session in which children will select their favorite toys, clothing, and decor options. This study is designed for children ages 3 to 7.
title: Ultra-low-dose chest CT: influence of body mass index and maximum thoracic transverse diameter on image quality
Creators: name: Ohana, Mickaël
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Thorax
subject: Radioprotection / Radiation dose
subject: CT
subject: Perception image
subject: Technology assessment

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Ultra Low Dose chest CT (ULD-CT) is an unenhanced CT examination acquired at a radiation dose lowered to that of a PA and lateral chest X-ray, i.e. a DLP < 20mGy.cm / Effective Dose <0.3mSv . Its image quality is degraded, yet remains diagnostic in...
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
Creators: name: Krepler, Clemens
name: Aplin, Andrew E.
name: Lu, Yiling
name: Jeay, Sebastien
name: Shields, Carol L.
name: Barzily-Rokni, Michal
name: Hoon, Dave S.
name: Davies, Michael A.
name: Nathanson, Katherine L.
name: Ryan, Randall W.
name: Darr, David
name: Walter, Annette
name: Vultur, Adina
name: Guarino, Michael
name: Feldman, Michael
name: Terai, Mizue
name: Frederick, Dennie T.
name: Kumar, Rakesh
name: Schuchter, Lynn
name: Mills, Gordon B.
name: Sato, Takami
name: Bennett, Joseph J.
name: Flaherty, Keith T.
name: Haydu, Lauren E.
name: Boxer, Matthew B.
name: Halilovic, Ensar
name: Petrelli, Nicholas J.
name: Beqiri, Marilda
name: Ocker, Matthias
name: Shannan, Batool
name: Amaravadi, Ravi
name: Brafford, Patricia
name: Liu, Qin
name: Watters, Andrea
name: Xiao, Min
name: Anastopoulos, Ioannis N.
name: Elder, David E.
name: Roesch, Alexander
name: Perego, Michela
name: Yin, Xiangfan
name: Zhang, Gao
name: Wilson, Melissa A.
name: Wuerthner, Jens
name: Xu, Xiaowei
name: Wubbenhorst, Bradley
name: Garman, Bradley
name: Wargo, Jennifer A.
name: Caponigro, Giordano
name: Gangadhar, Tara C.
name: Herlyn, Meenhard
name: Angus, Steve
name: Karakousis, Giorgos
name: Sproesser, Katrin
name: Xu, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma. PDX have been characterized using targeted sequencing and protein arrays and are clinically annotated. This exhaustive live tissue resource includes PDX from 57 samples resistant to targeted therapy, 61 samples from responders and non-responders to immune checkpoint blockade, and 31 samples from brain metastasis. Uveal, mucosal, and acral subtypes are represented as well. We show examples of pre-clinical trials that highlight how the PDX collection can be used to develop and optimize precision therapies, biomarkers of response, and the targeting of rare genetic subgroups.
title: Overcoming metallic artifacts on a low-field extremity MRI scanner and three-dimensional quantification of susceptibility artifacts
Creators: name: Buemi, Francesco
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: MR physics
subject: MR
subject: Physics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Dedicated MRI scanners are increasingly employed to study extremities because have many advantages over the whole body scanner (low weight, ease of installation in a limited spaces, decreased purchase and maintenance costs,better tolerated by...
The Effectiveness of Surfing on Mental Health: A scoping review
Creators: name: Foggo, Brock
name: Furness, James
name: Kemp-Smith, Kevin
name: Simas, Vini
name: Climstein, Mike
name: Woo, Douglas
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: Mental and Social Health

description: This protocol was developed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Extension for Scoping Reviews: Checklist and Explanation http://www.prisma-statement.org/Extensions/ScopingReviews. This protocol will be registered prospectively with the Open Science Framework. This scoping review aims to: Map the extent and level of evidence that exists specific to the effectiveness of surfing’s influence on symptoms of mental health. Identify the limitations of the current evidence specific to the effectiveness of surfing’s influence on symptoms of mental health, and to provide recommendations for future research on the topic.
Automatic Channel Network Extraction from Remotely Sensed Images by Singularity Analysis
Creators: name: Isikdogan, F.
name: Bovik, A. C.
name: Passalacqua, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Quantitative analysis of channel networks plays an important role in river studies. To provide a quantitative representation of channel networks, we propose a new method that extracts channels from remotely sensed images and estimates their widths. Our fully automated method is based on a recently proposed Multiscale Singularity Index that responds strongly to curvilinear structures but weakly to edges. The algorithm produces a channel map, using a single image where water and non-water pixels have contrast, such as a Landsat near-infrared band image or a water index defined on multiple bands. The proposed method provides a robust alternative to the procedures that are used in remote sensing of fluvial geomorphology and makes classification and analysis of channel networks easier. The source code of the algorithm is available at: http://live.ece.utexas.edu/research/cne/.
description: IEEE Geosci. Remote Sens. Lett., in review
Do LGBTQ-related Events Drive Individual Online Disclosure Decisions?
Creators: name: Jones, Jason
name: Cisternino, Irissa
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: being out
subject: big data
subject: coming out
subject: computational social science
subject: identity
subject: LGBT
subject: LGBTQ
subject: longitudinal
subject: pre-registered
subject: time series
subject: Twitter

description: When and how to come out are difficult choices. In this research project, we examine one form of disclosure: the addition of an LGBTQ keyword to one's online social media profile. We construct daily time series of the prevalence of LGBTQ keywords within American Twitter users' self-descriptions. Further, we construct daily time series of inferred add and drop events. These we compare to relevant annual and one-time events. We confirm or disconfirm our pre-registered hypotheses.
Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation
Creators: name: Macedo, Amanda B.
name: Szaniawski, Matthew A.
name: Planelles, Vicente
name: Margolis, David M.
name: Van Wagoner, Ryan M.
name: Ireland, Chris M.
name: Spivak, Adam M.
name: Martins, Laura J.
name: Novis, Camille L.
name: Nilson, Kyle A.
name: Bosque, Alberto
name: Price, David H.
name: Archin, Nancie M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The presence of latent HIV-1 in infected individuals represents a major barrier preventing viral eradication. For that reason, reactivation of latent viruses in the presence of antiretroviral regimens has been proposed as a therapeutic strategy to achieve remission. We screened for small molecules and identified several benzotriazole derivatives with the ability to reactivate latent HIV-1. In the presence of IL-2, benzotriazoles reactivated and reduced the latent reservoir in primary cells, and, remarkably, viral reactivation was achieved without inducing cell proliferation, T cell activation, or cytokine release. Mechanistic studies showed that benzotriazoles block SUMOylation of phosphorylated STAT5, increasing STAT5's activity and occupancy of the HIV-1 LTR. Our results identify benzotriazoles as latency reversing agents and STAT5 signaling and SUMOylation as targets for HIV-1 eradication strategies. These compounds represent a different direction in the search for "shock and kill" therapies.
title: Optimisation of the contrast media dose for abdominal MDCT using primitive and latent patient data
Creators: name: Nelson, Rendon
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Contrast agents
subject: Abdomen
subject: Vascular
subject: CT
subject: Contrast agent-intravenous

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The use of an intravenous bolus of iodinated contrast material for CT of the abdomen and pelvis is important for the detection and characterization of many anatomic and pathologic conditions. The contrast media injection protocol used by various...
Convexity of the extended K-energy and the large time behaviour of the weak Calabi flow
Creators: name: Berman, Robert J.
name: Darvas, Tamás
name: Lu, Chinh H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: Let $(X,ω)$ be a compact connected Kähler manifold and denote by $(\mathcal E^p,d_p)$ the metric completion of the space of Kähler potentials $\mathcal H_ω$ with respect to the $L^p$-type path length metric $d_p$. First, we show that the natural analytic extension of the (twisted) Mabuchi K-energy to $\mathcal E^p$ is a $d_p$-lsc functional that is convex along finite energy geodesics. Second, following the program of J. Streets, we use this to study the asymptotics of the weak (twisted) Calabi flow inside the CAT(0) metric space $(\mathcal E^2,d_2)$. This flow exists for all times and coincides with the usual smooth (twisted) Calabi flow whenever the latter exists. We show that the weak (twisted) Calabi flow either diverges with respect to the $d_2$-metric or it $d_1$-converges to some minimizer of the K-energy inside $\mathcal E^2$. This gives the first concrete result about the long time convergence of this flow on general Kähler manifolds, partially confirming a conjecture of Donaldson. Finally, we investigate the possibility of constructing destabilizing geodesic rays asymptotic to diverging weak (twisted) Calabi trajectories, and give a result in the case when the twisting form is Kähler. If the twisting form is only smooth, we reduce this problem to a conjecture on the regularity of minimizers of the K-energy on $\mathcal E^1$, known to hold in case of Fano manifolds.
description: v2. Introduction improved. Theorem 1.10 and Theorem 1.11 added. No further changes made
title: Cyclopent[cd]azulen und 1,2-Dihydro-dicyclopent[cd, ij]azulen
Creators: name: Hafner, Klaus
name: Meinhardt, Klaus-Peter
name: Richarz, Winfried
Publisher: name: Wiley
Year: 2023

description: Alkyl- sowie Aryl-Derivate[¹] des Cyclopent[cd]azulens (1) zeichnen sich durch eine bemerkenswerte Reaktivität bei Cycloadditionen mit Alkenen, Alkinen und Carbenen aus[²].
title: How to differentiate between recurrent, de novo and residual lesions of primary hepatocellular carcinoma after locoregional therapy
Creators: name: Bessar, Ahmed
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Interventional vascular
subject: Interventional non-vascular
subject: CT
subject: MR
subject: Ultrasound
subject: Ablation procedures
subject: Arterial access
subject: Chemoembolisation
subject: Neoplasia
subject: Cirrhosis
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Residual lesions after treatment of HCC are those lesions within the bulk of the targeted mass being not adequately ablated by thermal process or completely embolized with residual arterial activity seen within these lesions in arterial phase after...
Brieskorn Manifolds, Positive Sasakian Geometry, and Contact Topology
Creators: name: Boyer, Charles P.
name: Macarini, Leonardo
name: van Koert, Otto
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 53D42, 53C25

description: Using $S^1$-equivariant symplectic homology, in particular its mean Euler characteristic, of the natural filling of links of Brieskorn-Pham polynomials, we prove the existence of infinitely many inequivalent contact structures on various manifolds, including in dimension 5 the k-fold connected sums of $S^2\times S^3$ and certain rational homology spheres. We then apply our result to show that on these manifolds the moduli space of classes of positive Sasakian structures has infinitely many components. We also apply our results to give lower bounds on the number of components of the moduli space of Sasaki-Einstein metrics on certain homotopy spheres. Finally a new family of Sasaki-Einstein metrics of real dimension 20 on $S^5$ is exhibited.
description: 35 pages
Evaluation framework for using unconstrained conversational agents in health interventions: a systematic review protocol
Creators: name: Ding, Hang
name: Simmich, Joshua
name: Vaezipour, Atiyeh
name: Andrews, Nicole
name: Russell, Trevor
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences

description: Unconstrained conversational agents (UCAs) are powerful tools, allowing users to “talk” with machines/software programs to address their questions or needs. To use UCAs effectively and safely in health spaces, rigorous evaluations are essential but difficult to achieve. This review aimed to synthesize existing knowledge and outline a framework for evaluating UCAs in healthcare.
Long-range photon-mediated gate scheme between nuclear spin qubits in diamond
Creators: name: Auer, Adrian
name: Burkard, Guido
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Defect centers in diamond are exceptional solid-state quantum systems that can have exceedingly long electron and nuclear spin coherence times. So far, single-qubit gates for the nitrogen nuclear spin, a two-qubit gate with a nitrogen-vacancy (NV) center electron spin, and entanglement between nearby nitrogen nuclear spins have been demonstrated. Here, we develop a scheme to implement a universal two-qubit gate between two distant nitrogen nuclear spins. Virtual excitation of an NV center that is embedded in an optical cavity can scatter a laser photon into the cavity mode; we show that this process depends on the nuclear spin state of the nitrogen atom. If two NV centers are simultaneously coupled to a common cavity mode and individually excited, virtual cavity photon exchange can mediate an effective interaction between the nuclear spin qubits, conditioned on the spin state of both nuclei, which implements a universal controlled-$\textit{Z}$ gate. We predict operation times below 100 nanoseconds, which is several orders of magnitude faster than the decoherence time of nuclear spin qubits in diamond.
description: 6 pages (including 2 appendices), 3 figures, 1 table
title: Aneurysmal bone cyst of mandible
Creators: name: Mahal, Sayani
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Musculoskeletal system
subject: Musculoskeletal bone
subject: Musculoskeletal system
subject: CT
subject: Clinical Cases

description: Clinical History: A 22-year-old female patient presented with a selling on the right side of the chin which is gradually increasing in size. She did not have any previous history of trauma. On examination, facial asymmetry was present with a firm, non-tender swelling involving the right side of the lower jaw. On aspiration, blood-tinged fluid was obtained.

description: 22 years, female
Searching high and low for replicable associations between brain morphometry and personality
Creators: name: Hyatt, Courtland
name: Sharpe, Brinkley
name: Owens, Max
name: CARTER, NATHAN
name: Miller, Josh
name: Lynam, Donald
name: Listyg, Benjamin
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: Please see posted pre-registration on the main project page.
Recovery of Si-IV nanowires from extreme GPa pressure
Creators: name: Smith, Bennett E.
name: Zhou, Xuezhe
name: Roder, Paden B.
name: Abramson, Evan H.
name: Pauzauskie, Peter J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We use Raman spectroscopy in tandem with transmission electron microscopy and DFT simulations to show that extreme (GPa) pressure converts the phase of silicon nanowires from cubic (Si-I) to hexagonal (Si-IV) while preserving the nanowire's cylindrical morphology. In situ Raman scattering of the TO mode demonstrates the high-pressure Si-I to Si-II phase transition near 9 GPa. Raman signal of the TO phonon shows a decrease in intensity in the range 9 to 14 GPa. Then, at 17 GPa, it is no longer detectable, indicating a second phase change (Si-II to Si-V) in the 14 to 17 GPa range. Recovery of exotic phases in individual silicon nanowires from diamond anvil cell experiments reaching 17 GPa is also shown. Raman measurements indicate Si-IV as the dominant phase in pressurized nanowires after decompression. Transmission electron microscopy and electron diffraction confirm crystalline Si-IV domains in individual nanowires. Computational electromagnetic simulations suggest that heating from the Raman laser probe is negligible and that near-hydrostatic pressure is the primary driving force for the formation of hexagonal silicon nanowires.
title: A new MR follow-up algorithm for a proper management of “small” adrenal adenomas (AA)
Creators: name: Faletti, Riccardo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Management
subject: MR
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Wider availability and technical improvement of imaging technology have led to the accidental discovery of a growing number of silent and unrecognized adrenal masses. In radiologic studies, in fact, the frequency of incidentalomas is estimated to be...
Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes
Creators: name: Liu, Ziqing
name: Alimohamadi, Sahar
name: Wang, Li
name: Zhou, Yang
name: Yin, Chaoying
name: Liu, Jiandong
name: Qian, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources for heart regeneration or disease modeling. However, the similarities and differences between iPSC-CMs and iCMs are still unknown. Here, we performed transcriptome analyses of beating iPSC-CMs and iCMs generated from cardiac fibroblasts (CFs) of the same origin. Although both iPSC-CMs and iCMs establish CM-like molecular features globally, iPSC-CMs exhibit a relatively hyperdynamic epigenetic status, whereas iCMs exhibit a maturation status that more closely resembles that of adult CMs. Based on gene expression of metabolic enzymes, iPSC-CMs primarily employ glycolysis, whereas iCMs utilize fatty acid oxidation as the main pathway. Importantly, iPSC-CMs and iCMs exhibit different cell-cycle status, alteration of which influenced their maturation. Therefore, our study provides a foundation for understanding the pros and cons of different reprogramming approaches.
Digital signal processing for a thermal neutron detector using ZnS(Ag):6LiF scintillating layers read out with WLS fibers and SiPMs
Creators: name: Mosset, J. -B.
name: Stoykov, A.
name: Greuter, U.
name: Hildebrandt, M.
name: Schlumpf, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We present a digital signal processing system based on a photon counting approach which we developed for a thermal neutron detector consisting of ZnS(Ag):6LiF scintillating layers read out with WLS fibers and SiPMs. Three digital filters have been evaluated: a moving sum, a moving sum after differentiation and a digital CR-RC^4 filter. The performances of the detector with these filters are presented. A full analog signal processing using a CR-RC^4 filter has been emulated digitally. The detector performance obtained with this analog approach is compared with the one obtained with the best performing digital approach.
Neighborhood Level Predictors of Intimate Partner Sexual Violence: A Case Control Study
Creators: name: Carpenter, Rachel
name: Stinson, Jill
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Forensic Science and Technology
subject: Clinical Psychology
subject: Legal Studies
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: There is ample research exploring factors associated with intimate partner violence (IPV), yet individual, dyadic, and environmental influences on intimate partner sexual violence (IPSV) remain relatively unexplored. The current study aimed to determine the extent to which county-level indicators in combination with individual and dyadic factors are associated with IPSV. Reported IPSV cases were obtained from the Tennessee Bureau of Investigation’s (TBI) online incident-based reporting system. County-level variables indicative of neighborhood physical disorder, violent crime, income inequality, firearm prevalence, and community alcohol use patterns were retrieved from the online resource County Health Rankings and Roadmaps. Using a nested case control design, we determined significant IPSV risk within younger cohorts, elevated IPSV risk in multiple relationship types, and three significant county-level factors: 1) income inequality, 2) rate of firearm fatalities, and 3) percentage of female residents. Suggested prevention and intervention efforts include targeting younger age groups for IPSV education, developing resources for a range of relational partners, improving legal access and law enforcement training for IPSV reporting, and continued examination of the role of firearms in incidents of IPSV.
A Low-cost and Small USV platform for Water Quality Monitoring
Creators: name: Jo, Wonse
name: Hoashi, Yuta
name: Aguilar, Lizbeth
name: postigo, mauricio
name: Garcia-Bravo, José
name: Min, Byung-Cheol
Publisher: name: Open Science Framework
Year: 2022

description: This repository includes all hardware and software files to make a low-cost and small USV platform. The platform is able to acquire data like pH, turbidity, and temperature to measure water quality in real water resources (such as ponds, reservoirs, and lakes).
title: Interval cancer: a review of cases among patients included in the breast cancer screening programme of Galicia
Creators: name: Novo Amado, Alba
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: Screening
subject: Observer performance
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast cancer still remains both in Spain and in Europe as one of the leading causes of death among women. It represents a disease that causes a serious social concern and dismay among the population. It has been estimated that in 2008 about 332,770...
Informing a new agenda of research on callous-unemotional traits in alternative care: Protocol for a scoping review
Creators: name: Aquilina, Benjamin
name: Pasalich, Dave
name: Hassall, Alison
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Psychiatry and Psychology
subject: Personality and Social Contexts
subject: Medicine and Health Sciences
subject: Developmental Psychology
subject: Child Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: alternative care
subject: callous-unemotional traits
subject: foster care
subject: institutional care
subject: kinship care
subject: out-of-home care
subject: psychopathy
subject: residential care

description: This is the protocol for a scoping review synthesizing evidence regarding the levels, correlates, outcomes and intervention prospects of callous-unemotional traits (and the related construct of psychopathy) within an out-of-home/institutional care population. It is anticipated that the review will inform a new research agenda based on potential gaps in the existing literature.
Raman-scattering-assistant broadband noise-like pulse generation in all-normal-dispersion fiber lasers
Creators: name: Li, Daojing
name: Shen, Deyuan
name: Li, Lei
name: Chen, Hao
name: Tang, Dingyuan
name: Zhao, Luming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on the observation of both stable dissipative solitons and noise-like pulses with the presence of strong Raman scattering in a relatively short all-normal-dispersion Yb-doped fiber laser. We show that Raman scattering can be filtered out by intracavity filter. Furthermore, by appropriate intracavity polarization control, the Raman effect can be utilized to generate broadband noise-like pulses (NLPs) with bandwidth up to 61.4 nm. To the best of our knowledge, this is the broadest NLP achieved in all-normal-dispersion fiber lasers
description: 6 pages, 4 figures
Effect of external diaphragm pacing combined with limb exercise on acquired weakness of ICU in mechanically ventilated patients
Creators: name: Wu, yuehong
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: ICU acquired weakness (lCU-AW) refers to obvious muscle weakness with no reasonable cause except critical illness in ICU patients. It is usually systemic and symmetrical, affecting the limbs (the proximal end is more than the distal end) and the respiratory muscles.The existing preventive measures only focus on the prevention of risk factors or the rehabilitation of limb muscles, ignoring respiratory muscles.We put forward a comprehensive scheme of extracorporeal diaphragm pacing combined with limb exercise and compared with a single limb exercise scheme to explore the effect of the two schemes on the prevention of acquired weakness of ICU.Our inclusion criteria: ① age ≥ 18 years old ② admission ICU ≥ 24 hours, and expected hospitalization ≥ 5 days ③ included in the study, patients with MRC ≥ 48 points ④ hemodynamic stable, vital signs stable patients ⑤ventilator-assisted ventilation patients ⑥ patients with complete skin exposure of sternocleidomastoid muscle area ⑦ subjects or family members agreed to participate in this study ⑧ patients with clear consciousness and can cooperate with the examination. Exclusion criteria: ① patients with previous muscle weakness, such as pre-existing neuromuscular or neuromuscular diseases with functional defects② patients with temporary or permanent pacemakers③ patients with pulmonary embolism, deep venous thrombosis, etc. patients with hematological diseases. Traumatic patients with incomplete limbs, vertebral fractures or unstable multiple fractures ④ have contraindications to phrenic nerve stimulation (pneumothorax, active pulmonary tuberculosis, pleural thickening and adhesion, severe pulmonary infection, metal implants in the body) ⑤damage to the structure of the diaphragm, diaphragm paralysis or other known anatomical abnormalities of the diaphragm; lack of windows to see the thickness of the diaphragm.We will record the total time of mechanical ventilation, insulin and the dose of sedatives in both groups. The grip strength, MRC score, diaphragm mobility, diaphragm thickness score, cross-sectional area of rectus femoris, vital signs and ICU activity scale were recorded on the 1st, 3rd and 5th day after intervention.
Prior Setting In Practice: Strategies and rationales used in choosing prior distributions for Bayesian analysis
Creators: name: Sarma, Abhraneel
name: Kay, Matthew
Publisher: name: Open Science Framework
Year: 2022

description: This contains all the supplementary materials for this project (under files) which includes pre-registration, data collection materials, data (de-identified survey data, interview protocol and transcripts), and analysis of the data. It also includes a pre-print of the accepted manuscript.
title: Evaluation of iron accumulation in choroid plexus in patients with beta-thalassaemia major by using susceptibility weighted imaging (SWI)
Creators: name: Üre Esmerer, Emel
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: Haematologic
subject: MR
subject: Imaging sequences
subject: Haematologic diseases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: β-Thalassemia major is a common genetic hemoglobinopathy characterized by defective production of β-chains of hemoglobin, resulting in ineffective erythropoiesis, hemolysis, and severe anemia [1,2]. Conventional management of the patients with...