Additional file 1 of Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study
Creators: name: Trares, Kira
name: Bhardwaj, Megha
name: Perna, Laura
name: Stocker, Hannah
name: Petrera, Agnese
name: Hauck, Stefanie M.
name: Beyreuther, Konrad
name: Brenner, Hermann
name: Schöttker, Ben
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Additional file 1: Supplemental Table 1. List of biomarkers measured with Olink Proseek® Multiplex Inflammation I96x96 kits. Supplemental Table 2. Baseline characteristics of participants with (n=6284) and without (n=3656) available dementia information and blood samples. Supplemental Table 3. Baseline characteristics of selected (n=1278) and non-selected (n=4456) controls. Supplemental Table 4. Comparison of median Olink Inflammation panel biomarker levels between all-cause dementia cases (n=504) and controls (n=1278). Supplemental Table 5. Comparison of median Olink Inflammation panel biomarker levels between Alzheimer’s disease cases (n=163) and controls (n=1278). Supplemental Table 6. Comparison of median Olink Inflammation panel biomarker levels between vascular dementia cases (n=195) and controls (n=1278). Supplemental Table 7. Non-significant associations of Olink Inflammation panel biomarker levels with all-cause dementia incidence (FDR ≥ 0.05). Supplemental Table 8. Non-significant associations of Olink Inflammation panel biomarker levels with Alzheimer’s disease incidence (FDR ≥ 0.05). Supplemental Table 9. Non-significant associations of Olink Inflammation panel biomarker levels with vascular dementia incidence (FDR ≥ 0.05). Supplemental Table 10. Replication of strong associations of Olink Inflammation panel biomarker levels with all-cause dementia incidence with multivariate, weighted Cox proportional hazards regression. Supplemental Table 11. Replication of strong associations of Olink Inflammation panel biomarker levels with Alzheimer’s disease incidence with multivariate, weighted Cox proportional hazards regression. Supplemental Table 12. Replication of strong associations of Olink Inflammation panel biomarker levels with vascular dementia incidence with multivariate, weighted Cox proportional hazards regression. Supplemental Table 13. Olink Inflammation panel biomarkers in the CX3CL1 cluster. Supplemental Table 14. Olink Inflammation panel biomarkers in the EN-RAGE cluster. Supplemental Table 15. Olink Inflammation panel biomarkers in the LAP TGF-beta-1 cluster. Supplemental Table 16. Olink Inflammation panel biomarkers in the VEGF-A cluster. Supplemental Table 17. Exploratory subgroup and sensitivity analyses for the association of CX3CL1 and all-cause dementia. Supplemental Table 18. Exploratory subgroup and sensitivity analyses for the association of EN-RAGE and all-cause dementia. Supplemental Table 19. Exploratory subgroup and sensitivity analyses for the association of EN-RAGE and Alzheimer’s disease. Supplemental Table 20. Exploratory subgroup and sensitivity analyses for the association of LAP TGF-beta-1 and Alzheimer’s disease. Supplemental Table 21. Exploratory subgroup and sensitivity analyses for the association of VEGF-A and vascular dementia. Supplemental Table 22. Associations of five Olink inflammation panel biomarker levels with all-cause dementia, Alzheimer’s disease, and vascular dementia incidence modelled linearly and modelled with their best fitting function. Supplemental Table 23. Associations of IFN-gamma and TNF levels with all-cause dementia, Alzheimer’s disease and vascular dementia incidence for participants included in the third wave of measurements (t3) (n=388).