cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cyclocephala rondoniana Ratcliffe 1992
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala rondoniana

description: Cyclocephala rondoniana Ratcliffe, 1992
Cyclocephala rondoniana Ratcliffe 1992: 185 (Brazil)
Distribution. French Guiana: Duranton 2011: 15; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 240. Brazil: Ratcliffe 1992: 185; Moore et al. 2018b: 240.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 179, DOI: 10.5281/zenodo.3678492
Bey Linthal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877
Subjects: Kanton Glarus

description: Fronalpstock, Schilt und Heustock
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Genetic variations in apolipoprotein B and apolipoprotein A-I associated with risk of coronary artery disease
Creators: name: Ludwig, Erwin H.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Apolipoproteins

description: Increased plasma concentrations of apolipoprotein B (apoB) and low density lipoproteins (LDL) are directly associated with increased total cholesterol concentrations and increased risk of coronary artery disease (CAD). An inverse association exists between apolipoprotein A-I (apoA-I) and high density lipoprotein (HDL) concentrations with CAD. I hypothesized that common variations present in apoB and apoA-I account for the interindividual variance in LDL and HDL levels, respectively, and are associated with dyslipidemia and CAD. Seven genetic variations within the putative receptor - binding domain of apoB were identified. Only two variations, Arg 3500 Gln and Arg 3531 Cys were associated with familial defective apoB-100 binding to the LDL receptor. Combined they account for nearly one percent of hypercholesterolemia and one to two percent of CAD; a frequency equivalent to the sum of all known LDL receptor mutations. Mutations in the putative receptor binding domain of apoB do not account for the previously observed monogenic contribution of the apoB gene locus or plasma LDL variance. In addition, carriers of the apoB 3500-Gln allele do not necessarily express hypercholesterolemia or CAD; indicating that mutations in apoB act within the context of other genetic and environmental factors. A common polymorphism within the promoter of the apoA-I gene is associated with elevated apoA-I and HDL plasma concentrations, suggesting either a direct effect on promoter activity or linkage disequilibrium with another causal mutation elsewhere in the gene. The impact this polymorphism has on apoA-I expression was examined. The G(-78)A substitution exerted a significant effect on promoter activity in in vitro studies, but the direction (G > A or A >G) and magnitude of the difference observed depended on the promoter segment examined. At least three transacting factors, including Sp1 and Sp3 bind to the sequence surrounding G(-78)A. These differences in transcriptional activity as a function of promoter length are dependent on interactions of trans-acting factors with cis-elements presented within the apo A-I promoter. The evidence documents a significant effect of the G(-78)A on apoA-I promoter function in vitro, but the complexity of the noted effects precludes the formulation of specific inferences in humans.
title: Memoria 2011
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: En el marco del décimo cuarto año de su fundación, la Universidad Especializada de las Américas, pasa de ser una oportunidad tradicionalmente reservada a las minorías, para dar paso a una educación que alcanza con ciencia y excelencia a amplios sectores de nuestra sociedad con el objetivo de mantener una presencia académica reconocida a nivel nacional e internacional.
Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS
Creators: name: Froes, Thamires Quadros
name: Chaves, Bianca Trindade
name: Mendes, Marina Sena
name: Ximenes, Rafael Matos
name: da Silva, Ivanildo Mangueira
name: da Silva, Priscila Brandão Gomes
name: de Albuquerque, Julianna Ferreira Cavalcanti
name: Castilho, Marcelo Santos
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Statistics
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: The thiazolidinone ring is found in compounds that have widespan biology activity and there is mechanism-based evidence that compounds bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme in the biosynthesis of the virulence factor named pyocyanin. Ten novel thiazolidinone derivatives were synthesised and screened against PaPhzS, using two orthogonal assays. The biological results provided by these and 28 other compounds, whose synthesis had been described, suggest that the dihydroquinazoline ring, found in the previous hit (A- Kd = 18 µM and LE = 0.20), is not required for PaPzhS inhibition, but unsubstituted nitrogen at the thiazolidinone ring is. The molecular simplification approach, pursued in this work, afforded an optimised lead compound (13- 5-(2,4-dimethoxyphenyl)thiazolidine-2,4-dione) with 10-fold improvement in affinity (Kd= 1.68 µM) and more than 100% increase in LE (0.45), which follows the same inhibition mode as the original hit compound (competitive to NADH).Executive summaryPhzS is a key enzyme in the pyocyanin biosynthesis pathway in P. aeruginosa.Orthogonal assays (TSA and FITC) show that fragment-like thiazolidinedione derivatives bind to PaPhzS with one-digit micromolar affinity.Fragment-like thiazolidinedione derivatives bind to the cofactor (NADH) binding site in PaPhzS.The molecular simplification optimised the ligand efficiency and affinity of the lead compound. PhzS is a key enzyme in the pyocyanin biosynthesis pathway in P. aeruginosa. Orthogonal assays (TSA and FITC) show that fragment-like thiazolidinedione derivatives bind to PaPhzS with one-digit micromolar affinity. Fragment-like thiazolidinedione derivatives bind to the cofactor (NADH) binding site in PaPhzS. The molecular simplification optimised the ligand efficiency and affinity of the lead compound.
Regulation of pap pilin phase variation
Creators: name: Blyn, Lawrence Bruce
Publisher: name: University of Utah
Year: 2012
Subjects: Uropathogenic coli
Methylationstates

description: The regulation of expression of the pyelonephritis-associated pili (pap) pilin gene in Escherichia coli was investigated using a single copy lacZYA fusion system. The expression of pap-encoded pili is under the control of a heritable phase variation mechanism. Pap phase-variation is transcriptionally regulated and responsive to changes in the carbon source used for growth and the incubation temperature. Pilin phase variation occurs without DNA rearrangement of pap DNA sequences. Analysis of the DNA regulatory region upstream of the papBA promoter showed that there are two nearly perfect 27 base pair inverted repeats separated by 89 base pairs. Each inverted repeat contains a single Dam (deoxyadenosine methylase) methylation site (GATC1028 and GATC1130 sites). Using a pap-lac gene fusion, as well as primer extension analysis of papB mRNA, it was found that the dam gene product is required for pap transcription. The methylation states of the GATC028 and GATC1130 sites in DNAs isolated from transcriptionally phase on and phase off cells were different as evidenced by Southern blot experiments. The GATC1028 site was found to be unmethylated only in DNA isolated from phase on populations. Conversely, GATC1130 sites were unmethylated in DNA isolated from phase off populations. E. coli mutants were isolated that failed to protect both the GATC1028 and GATC 1130 sites from methylation by Dam. The defective gene(s) in these mutants was cloned and designated as mbf for methylation blocking factor. The mbf gene is located at 19.6 min on the E. coli chromosome. In mbf+ E. coli the GATC1130 site is umethylated (the phase off methylation state) in the absence of any pap-encoded proteins. Methylation protection of GATC1028 (the phase on methylation state) requires both mbf and papI, a regulatory gene within the pap operon, indicating that pap pilin phase variation requires the action of at least two genes, papI and mbf. A model is presented for pap pilin phase variation which predicts that the GATC methylation state regulates Mbf and PapI binding to pap DNA and that binding of Mbf and PapI inhibits the methylation of GATC sites by Dam methylase.
Cyclocephala rufonigra Demay 1838
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala rufonigra

description: Cyclocephala rufonigra Demay, 1838
Cyclocephala rufo-nigra Demay 1838: 23 (French Guiana)
Distribution. Guyana: Endrödi 1985a: 148; Moore et al. 2018b: 242. French Guiana: Demay 1838: 23. “Guianas”: Arrow 1937b: 15; Blackwelder 1944: 252. Other: Endrödi 1966a: 298 (none).
Note 1. Demay presented to a congress in Metz [France] a leaflet, accompanied by figures, containing allegedly the descriptions of thirteen beetle species found in French Guiana. He sent an extract of this leaflet to the Revue Zoologique, which was then published (Demay 1838: 23). This publication contains just eleven non-illustrated descriptions, one of which is the only known record of Cyclocephala rufonigra. The type locality is erroneously altered to “ Guyana ” in Endrödi (1985a: 148) and Moore et al. (2018b: 242).
Note 2. Burmeister (1847: 521) suspects Cyclocephala rufonigra may be synonymous with C. dorsalis (which is now a synonym of C. dispar). The present location of the type material is unknown and this species thus remains a species inquirendum.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 179, DOI: 10.5281/zenodo.3678492
Pathological mechanisms of interleukin-two induced hypotension and vascular leak syndrome
Creators: name: Kondapaneni, Muralidhar
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Pathology

description: We employed knockout mice (on C57BL/6 background) to test the role of the inducible nitric oxide synthase (iNOS) in mediating Il-2 toxicity.  In contrast to C3H/HeN mice, which developed hypotension and VLS after 10 does of only 180,000 IU IL-2, C57BL/6 mice were far more resistant to the effects of IL-2 requiring increased doses of 800,000 IU IL-2 (b.i.d. 5 days) to induce hypotension and VLS.  Serum IFN-gamma levels were significantly more elevated by IL-2 treatment in C3H/HeN mice than in C57BL/6.  Urinary excretion of NO metabolites was reduced about 70% in iNOS knockout mice (C57BL/6 iNOS-/-) following IL-2 treatment showing that this NOS isoform accounts for the majority of NO production during IL-2 treatment.  A surprising finding was that these mice still developed profound hypotension and VLS. Similar findings were observed following concomitant administration of an iNOS specific inhibitors, L-NIL and 1400W with Il-2.  In contrast a general nitric oxide synthase (NOS) inhibitor, N[G]-monomethly-L-arginine (MLA), prevented both hypotension and vascular lead.  The superoxide dismutase mimetic, M40403, reversed only IL-2 induced hypotension, but not VLS in knockout mice.  Thus, superoxide or peroxynitrite mediated mechanisms are likely responsible for hypotension, while NO-induced changed in vascular permeability results in VLS.  The iNOS enzyme is not necessary for pathogenesis of IL-2 induced cardiovascular toxicity.  Mice with a knockout endothelial nitric oxide synthase (eNOS), however, proved resistant to IL-2 induced hypotension and vascular lead syndrome.  Urinary excretion of NO metabolites in eNOS knockout mice was reduced about 30% following IL-2 treatment compared to controls.  These results imply that eNOS isoform plays a major role in the development of IL-2 induced cardiovascular toxicity.  There is significant difference in the levels of cytokines expression following IL-2 treatment of C3H/HeN mice of C5BL/6 mice.  We also found that LAK cell cytotoxicity is not essential for IL-2 induced hypotension and vascular leak as Beige mice (which lake NK and T-cell cytotoxicity) still show these cardiovascular responses.  Beige mice retain the capability to secrete cytokines following Il-2 treatment.  In contrast more severly deficient NIH-III knockout mice are partially resistant to IL-2 induced cardiovascular side effects suggesting that there are both cellular and non-cellular components to eNOS acativation.
Ob der Alp Schäferhütte Nüschen am Kistenpaas
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Fronalpstock, Schilt und Heustock
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
The Institutional Origins, Diffusion, and Establishment of Entrepreneurial Identities in the Global South: The Case of Brazil
Creators: name: De Almeida Coutinho, Aline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Entrepreneurship
Organizations
Performativity
Diffusion
Inequality
Brazil

description: The category of the entrepreneur has been increasingly adopted as a social identity in Brazil, a country where even the term ‘entrepreneurship’ was absent from ordinary language until recently (Melo, 2008). Where did this category come from? How does it disseminate in Brazil? And how do people come into contact and experience it? Research suggests that the end of the twentieth century witnessed the emergence of a socioeconomic agenda, policies, and discourses that placed entrepreneurship and the associated values of individualism, self-reliance, and enterprise culture in evidence (Audretsch, 2007; Boltanski & Chiapello, 1999; Gilbert, Audretsch, & McDougall, 2004; Keat & Abercrombie, 1991). These studies leave largely unaddressed the concrete mechanisms through which the category of the entrepreneur diffuses to the Global South. This thesis addresses this gap in the literature by applying an analytical framework that shines a spotlight on the practices of organizations that promote entrepreneurship in Brazil. Taking Empretec, Endeavor, and Online Networks of Support as case studies, I draw conceptual and methodological insights from policy diffusion and institutional analysis, science and technology studies, and organizational studies (Stone, 2012; Callon, 1998; Tomaskovic-Devey & Avent-Holt, 2019) to analyze data generated through interviews and content analysis. I argue that controversial aspects of post-War knowledge associated with the category of the entrepreneur gave way to an institutionalized normative and seemingly neutral depiction of the entrepreneur. I show how a growing number of organizations deploy varied strategies to encourage entrepreneurship and constitute entrepreneurial subjects in Brazil. It results in new groups performed across gender, racial, and class lines, with varying symbolic capital, and receiving support of different magnitude. Organizations that promote entrepreneurship are thus central in the dissemination of the category of the entrepreneur, but they inadvertently create a system of distribution of resources that exacerbates social inequalities.
To Remove and Replace? Examining Discourses in Support of and Opposition to Elite Efforts to Transform Community Housing Into a Transcarceral Space
Creators: name: Leblond, Alyssa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Prisoner re-entry
Community housing
Transcarceration
Poverty
Marxism
Abolitionism

description: Through engaging with hegemonic and counter-hegemonic discourses surrounding the Province of Ontario’s Community Housing Renewal Strategy (CHRS), this thesis examines the ways in which the criminalization and social assistance systems continue to be reimagined in ways that perpetuate inequality. The CHRS legislates the exclusion of criminalized individuals from accessing community housing. Drawing on Marxian punishment theory, the role of structural inequality as the foundation of such a policy is explored. A total of 150 documents comprise the final dataset; this includes newsprint media items, reports produced by non-governmental organizations, and Hansard transcripts. The analysis reveals a total of seven themes, which highlight how the CHRS is largely legitimized based on the principle of lesser eligibility. Through the hegemonic discourses, the recomposition and extension of the penal apparatus into the community housing sector is observed. Moreover, purveyors of counter-hegemonic discourses further illustrate this through highlighting the way in which the CHRS represents a state mechanism used to reproduce poverty and perpetuate its criminalization. In conclusion, future directions for research aiming to dismantle exclusive and punitive policies are suggested.
Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
Creators: name: Kitagawa, Daniel A. S.
name: Rodrigues, Rafael B.
name: Silva, Thiago N.
name: Santos, Wellington V. dos
name: da Rocha, Vinicius C. V.
name: de Almeida, Joyce S. F. D.
name: Bernardo, Leandro B.
name: Carvalho-Silva, Taynara
name: Ferreira, Cintia N.
name: da Silva, Angelo A. T.
name: Simas, Alessandro B. C.
name: Nepovimova, Eugenie
name: Kuča, Kamil
name: França, Tanos C. C.
name: de A. Cavalcante, Samir F.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a broad spectrum, are not effective towards all organophosphorus toxins, and have poor pharmacokinetics properties to allow them crossing the blood-brain barrier, hampering cholinesterase reactivation at the central nervous system. In this work, we designed and synthesised novel isatin derivatives, linked to a pyridinium 4-oxime moiety by an alkyl chain with improved calculated properties, and tested their reactivation potency against paraoxon- and NEMP-inhibited acetylcholinesterase in comparison to the standard antidote pralidoxime. Our results showed that these compounds displayed comparable in vitro reactivation also pointed by the in silico studies, suggesting that they are promising compounds to tackle organophosphorus poisoning.
Ring size changes in the development of class I HDAC inhibitors
Creators: name: Cho, Er-Chieh
name: Liu, Chi-Yuan
name: Tang, Di-Wei
name: Lee, Hsueh-Yun
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
Visual Impairment, Eye Disease and Their Risk of Depression and Cognitive Decline: The Canadian Longitudinal Study on Aging
Creators: name: Grant, Alyssa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Visual impairment
Age-related eye disease
Canadian Longitudinal Study on Aging
Depression
Cognitive decline

description: Objectives: Our goal was to explore the association between vision with cognitive change scores and incident depression. Methods: A 3-year prospective cohort study was performed. Incident depression was defined using a cut-off score of 10 on the Center for Epidemiologic Studies Depression scale. Cognitive change was examined by calculating the difference between baseline and follow-up cognitive tests scores. Multivariable Poisson and linear regression were used. Results: Cataract was associated with incident depression (relative risk=1.20, 95% confidence interval 1.05, 1.37). Visual impairment was associated with the 3-year change in Rey Auditory Verbal Learning Test (RAVLT) (β=-0.18, 95% CI= -0.28, -0.07), RAVLT-Delayed (β=-0.13, 95% CI= -0.25, -0.02), and Animal Naming Test (β=-0.95, 95% CI= -1.44, -0.45) scores. Glaucoma was associated with 3-year Mental Alternation Test change scores (β=-0.40, 95% CI -0.77, -0.04). Conclusions: Cataract was associated with increased depression risk. VI and glaucoma are associated with 3-year changes in cognitive test scores.
Von Nussbühl ob Linthal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Auf der Zeichnung ist der gezeichnete Berg als Bifertenstock beschriftet
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Intrauterine growth restriction alters hypothalmic programming in the developing mouse brain
Creators: name: Challis, Lauren
Publisher: name: University of Utah
Year: 2012
Subjects: Brain
Epigenetics
Hypothalamus
Intrauterine growth restriction
Mouse
Programming
Obesity

description: Intrauterine growth restriction (IUGR) creates altered programming in many organs, including the hypothalamus. Programming involves adaptive changes initiated to protect the survival of a fetus following IUGR, which can adversely influence the later response of genes that regulating energy balance. In male mice, IUGR coupled with rapid postnatal catch-up growth predisposes towards early onset obesity. One potential mechanism for this obesity is altered hypothalamic programming of intrahypothalamic cues involving prepro-orexin and prepro-MCH, two energy balance regulating genes as well as the extra-hypothalamic cues of peripheral hormones leptin and insulin. We therefore hypothesized that IUGR would alter hypothalamic programming of prepro-orexin and prepro-MCH genes in association with altered serum leptin and insulin levels in male mice at postnatal day 7 (P7) and P60. IUGR was induced via maternal thromboxane A2-analog infusion in the last week of C57BL/6J mouse gestation. Sham operated dams acted as controls. Sham and IUGR offspring were cross-fostered to unmanipulated dams and weaned to standard mouse chow at P21. In this mouse model, IUGR males, as compared to IUGR females, achieve rapid catch-up growth to sham males by P28 whereas IUGR females do not catch-up to sham females until P77. We measured mRNA levels via quantitative real-time RT-PCR, protein levels via Western immunoblotting, serum leptin and insulin levels via ELISA, and food intake from P21 to P60.
Der  Nüschenstock am Kistenpass : von unter Muttenwand
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Elastin gene expression in human skin fibroblasts during development and in heritable diseases
Creators: name: Sephel, Gregory Charles
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology

description: The phenotypic expression of tropoelastin (TE) by cultured human skin fibroblasts was studied utilizing an enzyme-linked immunosorbant assay (ELISA). Tropoelastin production, on a per cell basis, was found to be serum and density dependent, linear for at least 72h, and stable over approximately 28 population doublings. Rates of TE accumulation in culture medium were not significantly altered by cell-associated degradation. Standardized culture conditions were used to establish the normal production values for human skin fibroblasts at 25-69 x 10('3) molecules per cell per hour. A decline in TE production was shown to accompany the aging of cells in vitro and TE production appeared to decline in cells from donors aged beyond the sixth decade. Developmental initiation of TE production by human fetal fibroblast strains was shown to initiate at the 19th week of gestation. The induction was pretranslationally controlled, as evidenced by the simultaneous appearance of elastin specific transcripts. Relative total collagen synthesis and type I collagen (alpha 2 chain) mRNA expression were invariant over the same period, implying that these two genes are under different developmental control. The premature aging syndrome, Hutchinson-Gilford progeria, results from a fatal genetic defect which affects primarily tissues of mesodermal origin. TE produced by three progeroid fibroblast strains, which was shown to migrate with TE peptides secreted by normal cells, was increased 5- to 10-fold, while total protein synthesis was found to be normal. Expression of elastin specific transcripts, measured by dot blot analysis, was shown to be similarly increased, suggesting modified control at the pretranslational level. Finally, six cell strains from donors with apparent autosomal recessive cutis laxa were examined for defects in elastin metabolism. Absolute TE production by three cutis laxa cell strains was significantly decreased when compared to an age-matched normal average. Two strains exhibited significantly reduced relative TE production, which was also associated with reduced expression of TE transcripts. These studies represent the first systematic characterization of elastin synthesis by a human cell strain. They also advance the first biochemical evidence for initiation of elastin synthesis during human development and its altered expression in two heritable human developmental diseases.
Kärpfstock vom Rinderlöchli ob Ortstafel 1748
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Materials for energy storage in lithium-ion batteries
Creators: name: Tan, Jiajia
Publisher: name: University of Utah
Year: 2013
Subjects: Cathode
Lithium-ion batteries
Solid-state electrolyte
Thin-film batteries

description: Electric vehicles using on-board electricity as a power source have been commercialized for application in a small part of the automobiles market. For wide substitution of the current gasoline-powered vehicles, a lot of effort should be placed on improving the performance of lithium-ion batteries (LIBs), which are the dominant power sources of recent groups of electric vehicles. In this work, we studied several promising cathode and solid-state electrolyte materials for realization of high-capacity, high-safety LIBs. Poly-anionic LiFePO4 and Li2FeP2O7 have been considered very promising cathode materials for LIBs. They have large specific capacities, high thermal and chemical stability, and low cost. However, both of them have the same problem of low ionic and electronic conductivities. In order to speed up the kinetics in the LIBs, these poly-anionic materials were synthesized by developing a simple and high-throughput solution-based technique. The sort of chelating agent and the amount of carbon atoms in the starting solution were varied and the optimal parameters were found for LiFePO4 and Li2FeP2O7, respectively. The safety issue is another important factor for electric vehicles; it is not ensured by current LIBs using organic liquid electrolytes, which are flammable and volatile, prone to leak and decompose at high temperatures. Therefore, recent research has been focused on developing solid-state electrolytes. In this work, high-quality garnet-type iv Li7La3Zr2O12 (LLZO) electrolytes were synthesized using a solution-based technique. The ionic conductivity of cubic LLZO was revealed to be 1.67×10-4 S/cm. A proto-type cell comprised of LLZO electrolyte, LiCoO2 cathode and lithium metal anode was assembled. The cell possessed a gravimetric discharge capacity of 3.4 mAh/g. This value is quite low compared to conventional cells, mainly due to its large interfacial resistance. For improving the interfacial contact, LLZO was fabricated into thin films by pulsed laser deposition technique. The films deposited at room temperature had amorphous structure, and exhibited a lithium-ion conductivity of 3.35×10-7 S/cm. The effects of annealing on the properties of the films were investigated. Films annealed properly were found to have an enhanced lithium-ion conductivity value of 7.36×10-7 S/cm. Moreover, the as-deposited thin films were found to be electrochemically stable against lithium metal.
Cyclocephala rufovaria Arrow 1911
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala rufovaria

description: Cyclocephala rufovaria Arrow, 1911
Cyclocephala rufovaria Arrow 1911b: 173 (Ecuador, Peru)
Distribution. French Guiana: Duranton 2011: 15; Ponchel 2011: 60; Brûlé and Dalens 2012a annex 4: 18; Dupuis 2016b: 109; Moore et al. 2018b: 242. Brazil: Endrödi 1966a: 298, 1985a: 94, 136; Moore et al. 2018b: 242. Other: Arrow 1911b: 173 (Ecuador, Peru), 1937b: 15 (Ecuador, Peru); Blackwelder 1944: 252 (Ecuador, Peru); Endrödi 1966a: 298 (Ecuador, Peru), 1985a: 94, 136 (Ecuador, Peru); Moore et al. 2018b: 242 (Colombia, Ecuador, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 180, DOI: 10.5281/zenodo.3678492
The Impact of Oral Antidiabetics on Weight in the Elderly with Type 2 Diabetes Mellitus in the Ambulatory Setting
Creators: name: Tasic, Dusica
Publisher: name: University of Utah
Year: 2014

description: Comparison of data gathered in an electronic medical record (EMR) database on Type 2 Diabetes Mellitus (T2DM) patients age 65 years and older with oral antidiabetics (OAD) agent prescription and recorded body mass index (BMI)/weight was performed. A retrospective review of the General Electric Centricity Medical Quality Improvement Consortium (MQIC) research database containing the ambulatory health records of US patients was conducted. T2DM patients age 65 and older were identified by diagnosis,OADprescription or both. Sixmonths of continuousOADactivity was required; 395 days pre-index-date (index datewas defined by firstOADprescription) clinical activity was required. Two BMI and weight readings were mandated, at baseline, closest to index date and follow-up, closest to 6 months after initiation of OAD activity. A historical, longitudinal cohort design was used and data were analyzed using analysis of variance (ANOVA) with Tukey test for adjustment of the differences in the means between the groups for continuous variables; Pearson's Chi-square test was used to test association for categorical variables. The overall mean age for all of the OAD groups was 72.7 years. The values of the baseline diastolic blood pressure (DBP) differed (p=0.0009), as well as age (p< 0.001); DBP indicated patients were in Hypertension Stage 1. The baseline A1C level was shown to be statistically significant between the groups (p< 0.001) with the highest mean value in sulfonylureas group (7.7). Significant differences between theOADgroups were also found in respect to race and smoking status (p=0.004 and < 0.0001). In comparison between the baseline and the follow-up values, statistical significance was found in both of the outcomes and a drop of 0.7 BMI units was initiated among all of theOAD groups. The overall mean BMI value among all of the OAD groups was 29.08 kg/m². The change in BMI after 6 months of monotherapy demonstrated that meglitinides had the biggest decrease in BMI (-1.27), followed by the metformin group (-1.06) and the sulfonylureas showed the least BMI drop (-0.14).Weight as the secondary outcome variable demonstrated an average 3.97 lb weight loss between all of the OAD groups. Major weight loss was found in the meglitinides users (-7.82lb), pursued by the metformin group (-6.41lb); the sulfonylureas group reported the least weight loss (-0.89lb). EMR data demonstrated an association between the OAD user and BMI/weight and associated conditions consistent with elderly T2DM patients in a real-world setting. The likelihood of weight loss was somewhat consistent with the previous literature, except in the case of the TZD group, where the literature showed the expected weight gain and this study does not support these findings.
Flüchtige Skizze vom Alpeli 1227 mt ob Braunwald : bey starkem Wind und Nebel in d. Bergen
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Computerized laboratory alerting system to warn of life-threatening events
Creators: name: Bradshaw, Karen Elaine Harris
Publisher: name: University of Utah
Year: 2012
Subjects: Computerized Laboratory Alerting System
Utah
LDS Hospital

description: A computerized laboratory alerting system (CLAS) was developed using the decision-making capabilities of the HELP computer system at LDS Hospital in Salt Lake City, Utah. The CLAS generated alerts on life-threatening conditions indicated by laboratory test results and other patient data stored in HELP's computerized patient database. An effective alert feedback mechanism was developed which promoted quick review and acknowledgement of alerts by health care personnel. An evaluation of the effect of the CLAS on patient care and outcome was carried out. Results of the evaluation showed that general nursing floor patients with alerts for hypokalemia, falling potassium, hyperkalemia, hypokalemia--patient on digoxin, hyponatremia, falling sodium, hypernatremia, hypoglycemia and hyperglycemia were treated appropriately 68.1% of the time before CLAS implementation ('pre' study period) and 83.8% of the time after CLAS implementation ('post' study period, p = 0.017). The average number of hours which patients spent in the life-threatening conditions decreased from 30.4 hours in the 'pre' study period to 15.7 hours in the 'post' study period (p = 0.0125). The average patient length of stay also decreased from 350.6 hours in the 'pre' study period to 211.9 hours in the 'post' study period (p = 0.025). Results of the evaluation did not show significant differences in the number of times patients were handled appropriately, or in patient length of stay for general nursing floor patients generating alerts for metabolic acidosis. There was, however, a significant decrease in the average number of hours spent in the life-threatening condition (44.3 hours in the 'pre' study period vs. 26.5 hours in the 'post' study period, p = 0.033) for patients with metabolic acidosis alerts on the general nursing floors. Nurses were the major users of the CLAS (53.0%), followed by physicians (28.5%), ward clerks (11.5%), and other users (7.0%). The overall assessment of the value of the CLAS by users was positive. The CLAS was classified as very useful by 25.6% of users, frequently useful by 24.4% of users, somewhat useful by 34.6% of users, seldom useful by 7.7% of users, and not useful by 7.7% of users.
An ozonation treatment system for oil spill
Creators: name: Xiao, Ting
Publisher: name: University of Utah
Year: 2012
Subjects: Ozonation

description: With increasing industrial activities in many parts of the world, a large amount of crude oil is being consumed daily. With the large number of offshore and onshore oil fields along with the transportation of crude oil and its products, the risk of oil spill increases accordingly. Big crude oil spill accidents have caused not only loss of the energy resource but also significant contamination to the environment and ecosystems, attracting intense attention in each occurrence. Small oil spills occur frequently, but with less notice worldwide on a daily basis on land, at sea, and throughout inland freshwater systems. Various approaches have been proposed to decontaminate oil spill sites according to individual environmental constraints. The main methods for in situ oil spill clean-up include biodegradation, controlled burning, sorption, dispersion, along with chemical oxidation, filtration, membrane process, and adsorption for lower oil concentrations. These existing methods have their own drawbacks such as long duration and harmful intermediates; new effective methods using a combination of the existing methods are necessary. In this study, a process train utilizing flotation, stage-1 sand filtration, heightened ozonation (HOT), and stage-2 sand filtration was used to deal with oil-contaminated water (2.5% oil) that would simulate oil spills under different water conditions, including tap water, Utah Lake water, and Great Salt Lake water representing fresh water, groundwater, and sea water contamination. Treatment was carried under different conditions and the optimum conditions were identified. Excellent operation flowrates were found to be 5.2, 8, and 2 cm/min for the flotation column, the first-stage sand filtration, and the second-stage sand filtration, respectively. The results showed that HOT treatment of 8 cycles at 100 psi was most effective and economical in terms of dosage for achieving desirable effluent quality (84.76% O&G removal) and sand filter's life capacity (150 times the sands volume before sands were exhausted). The new treatment train achieved 99.9 % oil and grease removal and > 99.8 % COD removal, with increased sCOD and BOD/COD ratio, which indicated the potential of further polishing biological treatment if needed.
Visualizing program memory behavior using memory reference traces
Creators: name: Choudhury, A.N.M. Imroz
Publisher: name: University of Utah
Year: 2012
Subjects: Cache
Memory
Memory reference traces
Visualization
Memory behavior

description: Computer programs have complex interactions with their underlying hardware, exhibiting complex behaviors as a result. It is critical to understand these programs, as they serve an importantrole: researchers use them to express new ideas in computer science, while many others derive production value from them. In both cases, program understanding leads to mastery over these functions, adding value to human endeavors. Memory behavior is one of the hallmarks of general program behavior: it represents the critical function of retrieving data for the program to work on; it often reflects the overall actions taken by the program, providing a signature of program behavior; and it is often an important performance bottleneck, as the the memory subsystem is typically much slower than the processor. These reasons justify an investigation into the memory behavior of programs. A memory reference trace is a list of memory transactions performed by a program at runtime, a rich data source capturing the whole of a program's interaction with the memory subsystem, and a clear starting point for investigating program memory behavior. However, such a trace is extremely difficult to interpret by mere inspection, as it consists solely of many, many addresses and operation codes, without any more structure or context. This dissertation proposes to use visualization to construct images and animations of the data within a reference trace, thereby visually transmitting structures and events as encoded in the trace. These visualization approaches are designed with different focuses, meant to expose various aspects of the trace. For instance, the time dimension of the reference traces can be handled either with animation, showing events as they occur, or by laying time out in a spatial dimension, giving a view of the entire history of the trace at once. The approaches also vary in their level of abstraction from the hardware: some are concretely connected to representations of the memory itself, while others are more free-form, using more abstract metaphors to highlight general behaviors and patterns, which in turn characterize the program behavior. Each approach delivers its own set of insights, as demonstrated in this dissertation.
Vom Hüttenberg Braunwald
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Blick zum Ausläufer Saasberg und Diestal
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Unit Costs of Health and Social Care 2023 Manual
Creators: name: Jones, Karen C.
name: Weatherly, Helen
name: Birch, Sarah
name: Castelli, Adriana
name: Chalkley, Martin
name: Dargan, Alan
name: Forder, Julien E.
name: Gao, Minyue
name: Hinde, Seb
name: Markham, Sarah
name: Premji, Shainur
name: Findlay, D.
name: Teo, H.
Publisher: name: Personal Social Services Research Unit (University of Kent) & Centre for Health Economics (University of York)
Year: 2024

description: Knowing the cost of specific health and social care services is crucial information for making decisions about what support is provided to those who need help, assisting service providers to plan for the future of their services, and more generally for allocating scarce resources and budgets. To support resourcing decisions, the Unit Cost Programme has been carried out by the Personal Social Services Research Unit (PSSRU) at the University of Kent. They produced the annual cost estimates for the delivery of health and social care services for 29 years. Lesley Curtis, a Senior Research Fellow at PSSRU led the Unit Costs of Health and Social Care programme, alongside Jennifer Beecham, Ann Netten and Amanda Burns. In 2020, Karen Jones, Co-Director of PSSRU, led the programme for two years.

The annual publication is freely available online. The work is underpinned by three key principles:

1. The provision of robust, consistent estimates of costs based on economic theory and reflecting the long-run marginal opportunity cost.

2. Comprehensive coverage of available health and social care services, reflective of new service developments.

3. Clarity and accessibility in the presentation of cost estimates.

The annual volume included nationally-applicable costs for around 80 health and adult social care services (NHS, local authority, private and voluntary) as well as at least three articles by academics and practitioners each year. Unit costs represents the total expenditure incurred to produce one unit of output in health and social care. For example, the cost of one hour of a nurse or GP’s time, or a face-to-face appointment with a social worker or perhaps a speech therapist. It could also be a week in a residential care or nursing home or the cost of a day care attendance.

The consistency, comprehensiveness and robustness of what was produced over time has seen the volumes become a cornerstone of economic evaluations and a resource to inform deliberations among decision-makers.
Image reconstruction in dynamic contrast enhanced magnetic resonance imaging
Creators: name: Chen, Liyong
Publisher: name: University of Utah
Year: 2012
Subjects: Cardiac
Compressed sensing
Constrained reconstruction
Image reconstruction
MRI

description: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a powerful tool to detect cardiac diseases and tumors, and both spatial resolution and temporal resolution are important for disease detection. Sampling less in each time frame and applying sophisticated reconstruction methods to overcome image degradations is a common strategy in the literature. In this thesis, temporal TV constrained reconstruction that was successfully applied to DCE myocardial perfusion imaging by our group was extended to three-dimensional (3D) DCE breast and 3D myocardial perfusion imaging, and the extension includes different forms of constraint terms and various sampling patterns. We also explored some other popular reconstruction algorithms from a theoretical level and showed that they can be included in a unified framework. Current 3D Cartesian DCE breast tumor imaging is limited in spatiotemporal resolution as high temporal resolution is desired to track the contrast enhancement curves, and high spatial resolution is desired to discern tumor morphology. Here temporal TV constrained reconstruction was extended and different forms of temporal TV constraints were compared on 3D Cartesian DCE breast tumor data with simulated undersampling. Kinetic parameters analysis was used to validate the methods.
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Creators: name: Mehndiratta, Samir
name: Chen, Mei-Chuan
name: Chao, Yuh-Hsuan
name: Lee, Cheng-Hsin
name: Liou, Jing-Ping
name: Lai, Mei-Jung
name: Lee, Hsueh-Yun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitution at C3 of quinoline is favoured for HDAC6 selectivity. Two compounds (25 and 26) were also found to be potent anti-proliferative compounds with IC50 values ranging from 1.29 to 2.13 µM against A549 and HCT116 cells. These compounds displayed remarkable selectivity for HDAC6 over other HDAC isoforms with nanomolar IC50 values. Western blot analysis revealed that compounds of this series activate apoptotic caspase pathway as indicated by cleavage of caspase 3, 8, and 9 and also increase phosphorylated H2AX thus inducing DNA double strand fragmentation in a concentration dependent manner. Flow cytometric analysis also displayed a dose dependent increase of cell population in sub G1 phase.