cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The C5a Receptor on Mast Cells Is Critical for the Autoimmune Skin-blistering Disease Bullous Pemphigoid
Creators: name: Berkowitz, Paula
name: Liu, Zhi
name: Diaz, Luis A.
name: Rubenstein, David S.
name: Li, Zhuowei
name: Heimbach, Lisa
name: Li, Ning
name: Zhao, Minglang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Bullous pemphigoid (BP) is an autoimmune skin-blistering disease characterized by the presence of autoantibodies against the hemidesmosomal proteins BP230 and BP180. In the IgG passive transfer mouse model of BP, subepidermal blistering is triggered by anti-BP180 antibodies and depends on the complement system, mast cell (MC) degranulation, and neutrophil infiltration. In this study, we have identified the signaling events that connect the activation of the complement system and MC degranulation. We found that mice deficient in MCs or the C5a receptor (C5aR) injected with pathogenic anti-BP180 IgG failed to develop subepidermal blisters and exhibited a drastic reduction in p38 MAPK phosphorylation compared with WT mice. Local reconstitution with MCs from WT but not C5aR-deficient mice restored high levels of p38 MAPK phosphorylation and subepidermal blistering in MC-deficient mice. Local injection of recombinant C5a induced phosphorylation of p38 MAPK in WT but not MC-deficient mice. Cultured mouse MCs treated with recombinant C5a exhibited a significant increase in p38 MAPK phosphorylation and MC degranulation. Taken together, these data demonstrate that C5a interacts with C5aR on MCs and that this C5a-C5aR interaction triggers activation of the p38 MAPK pathway, subsequent MC degranulation, and ultimately BP blistering.
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE
Creators: name: Ford, Robert C.
name: O'Ryan, Liam P.
name: Hughes, Guy
name: Aleksandrov, Luba A.
name: Zhao, Zhefeng
name: Rosenberg, Mark F.
name: Riordan, John R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Cystic fibrosis affects about 1 in 2500 live births and involves loss of transmembrane chloride flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). We have studied CFTR structure by electron crystallography. The data were compared with existing structures of other ATP-binding cassette transporters. The protein was crystallized in the outward facing state and resembled the well characterized Sav1866 transporter. We identified regions in the CFTR map, not accounted for by Sav1866, which were potential locations for the regulatory region as well as the channel gate. In this analysis, we were aided by the fact that the unit cell was composed of two molecules not related by crystallographic symmetry. We also identified regions in the fitted Sav1866 model that were missing from the map, hence regions that were either disordered in CFTR or differently organized compared with Sav1866. Apart from the N and C termini, this indicated that in CFTR, the cytoplasmic end of transmembrane helix 5/11 and its associated loop could be partly disordered (or alternatively located).
Editorial: Advances in statistical methods for the genetic dissection of complex traits in plants
Creators: name: Xie, Shang-Qian
name: Jia, Zhenyu
name: Zhang, Yuan-Ming
name: Wang, Shibo
name: Zhang, Ya-Wen
name: Wen, Jia
Publisher: name: Frontiers Media SA
Year: 2024

description: In real data analysis, most commonly used genome-wide association study (GWAS) methods often miss some important loci and trait heritability. To address these challenges, Li et al. (2022a) established an innovative method named 3VmrMLM based on a compressed variance component mixed model. In 3VmrMLM, all the effects in quantitative trait nucleotide (QTN), QTN-by-environment interaction (QEI), and QTNby-QTN interaction (QQI) detection are compressed into an effect-related vector, while all polygenic backgrounds are compressed into a vector-related polygenic background. This method is especially well suited for species with a high proportion of heterozygous genotypes, such as human, forests, chrysanthemums, and grasslands.
(3965) William Adam Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Self-Assembled Metamaterial for Lamb Waves
Creators: name: Khanolkar, Amey
name: Wallen, Samuel
name: Ghanem, Maroun Abi
name: Jenks, Jennifer
name: Vogel, Nicolas
name: Boechler, Nicholas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We report the design and characterization of a self-assembled, locally resonant acoustic metamaterial for Lamb waves, composed of a monolayer of $1.02$ $μ$m polystyrene microspheres adhered to a $1.3$ $μ$m thick free-standing silicon membrane. A laser-induced transient grating technique is used to generate Lamb waves in the metamaterial and measure its acoustic response. The measurements reveal a microsphere contact resonance and the lowest frequency spheroidal microsphere resonance. The measured dispersion curves show hybridization of flexural Lamb waves with the microsphere contact resonance. We compare the measured dispersion with an analytical model using the contact resonance frequency as a single fitting parameter, and find that it well describes the observed hybridization. Results from this study can lead to an improved understanding of microscale contact mechanics and to the design of new types of acoustic metamaterials.
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
Creators: name: Lindsey-Boltz, Laura A.
name: Sancar, Aziz
name: Kemp, Michael G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A variety of environmental, carcinogenic, and chemotherapeutic agents form bulky lesions on DNA that activate DNA damage checkpoint signaling pathways in human cells. To identify the mechanisms by which bulky DNA adducts induce damage signaling, we developed an in vitro assay using mammalian cell nuclear extract and plasmid DNA containing bulky adducts formed by N-acetoxy-2-acetylaminofluorene or benzo(a)pyrene diol epoxide. Using this cell-free system together with a variety of pharmacological, genetic, and biochemical approaches, we identified the DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) as bulky DNA damage-stimulated kinases that phosphorylate physiologically important residues on the checkpoint proteins p53, Chk1, and RPA. Consistent with these results, purified DNA-PK and ATM were directly stimulated by bulky adduct-containing DNA and preferentially associated with damaged DNA in vitro. Because the DNA damage response kinase ATM and Rad3-related (ATR) is also stimulated by bulky DNA adducts, we conclude that a common biochemical mechanism exists for activation of DNA-PK, ATM, and ATR by bulky adduct-containing DNA.
First records of Kinorhyncha from the Gulf of California: horizontal and vertical distribution of four genera in shallow basins with CO2 venting activity
Creators: name: ÁLVAREZ-CASTILLO, Lucía
name: HERMOSO-SALAZAR, Margarita
name: ESTRADAS-ROMERO, Alejandro
name: PROL-LEDESMA, Rosa María
name: PARDOS, Fernando
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The Wagner and Consag Basins, in the northern end of the Gulf of California are characterized by active CO2 gas vents. This venting activity causes a decrease in the pore water pH compared to other marine environments and the acidification of the bottom water is expected to affect the organisms that inhabit the sediments. In this study, we present the first records of four genera and ten "working species" of the phylum Kinorhyncha in Mexico. We also analyzed their horizontal and vertical distribution. Samples were collected at 40 soft bottom sites on board of the R/V "El Puma" (WAGNER-02 Expedition) during July-August 2010 with a Smith McIntyre grab and a syringe corer. At each station physicochemical variables were measured including pore water pH. In this study, Kinorhyncha represented 2.64% of the total meiofauna and it ranked fourth in dominance after Nematoda, Copepoda, and Polychaeta. Kinorhynchs densities ranged from zero to 24.05 ind.10 cm-2. We encountered a total of two families, four genera and ten "working species" of kinorhynchs. The family Pycnophyidae was represented by two genera Pycnophyes (two "working species") and Kinorhynchus (five "working species") and the family Echinoderidae, two "working species" of the genus Echinoderes and one "working specie" of Fissuroderes were present. Kinorhynchs were mainly concentrated in the upper layers, with about 84% of the individuals present in the first four centimeters. This is the first ecological study of the phylum Kinorhyncha in Mexico and in a CO2 venting - low pH environment, registering also for the first time some data on the pH tolerance of these four kinorhynchs genera.
The Dominating Role of N -Deacetylase/ N -Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate
Creators: name: Xu, Yongmei
name: Liu, Jian
name: Liu, Renpeng
name: Sheng, Juzheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Heparan sulfate (HS) is a highly sulfated polysaccharide participated in essential physiological functions from regulating cell growth to blood coagulation. HS contains sulfated domains known as N-S domains and low sulfate domains known as N-Ac domains. The distribution of the domain structures is likely governed by the action of glucosaminyl N-deacetylase/N-sulfotransferase (NDST). Here, we sought to determine the substrate specificity of NDST using model substrates and recombinant NDST protein. We discovered that NDST-1 carries out the modification in a highly ordered fashion. The enzyme sulfates the substrate from the nonreducing end toward the reducing end consecutively, leading to the product with a cluster of N-sulfo glucosamine residues. Furthermore, a preexisting N-sulfo glucosamine residue prevents the action of NDST-1 at the residues immediately located at the nonreducing end, allowing the formation of an N-Ac domain. Our results provide the long sought evidence for understanding the formation of sulfated versus nonsulfated domains in the HS isolated from cells and tissues. The study demonstrates the regulating role of NDST-1 in mapping the sulfation patterns of HS.
Asymptotic normalization coefficients of resonant and bound states from the phase shifts for $αα$ and $α^{12}\rm C$ scattering
Creators: name: Orlov, Yu. V.
name: Irgaziev, B. F.
name: Nikitina, L. I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Recently we have published a paper [Irgaziev, Phys. Rev. C 91, 024002 (2015)] where the $S$-matrix pole method (SMP) which is only valid for resonances has been developed to derive a new explicit expression for the asymptotic normalization coefficient (ANC), and is applied to the low-energy resonant states of nucleon$+α$ and $α+^{12}\rm{C}$ systems. The SMP results are compared with the effective-range expansion method (EFE) results. In the present paper the SMP and EFE plus the Padé-approximation are applied to study the excited 2$^+$ resonant states of $^{8}\rm{Be}$. A contradiction is found between descriptions of the experimental phase shift data for $αα$ scattering and of the $^{8}\rm{Be}$ resonant energy for 2$^+$ state. Using the EFE method, we also calculate the ANC for the $^{8}\rm{Be}$ ground 0$^+$ state with a very small width. This ANC agrees well with the value calculated using the known analytical expression for narrow resonances. In addition, for the $α+^{12}\rm{C}$ states1$^-$ and 3$^-$ the SMP results are compared with the Padé-approximation results. We find that the Padé-approximation improves a resonance width description compared with the EFE results. The EFE method is also used to calculate the ANCs for the bound $^{16}\rm{O}$ ground 0$^+$ state and for the excited 1$^-$ and 2$^+$ levels which are situated near the threshold of $α+^{12}\rm{C}$ channel.
description: 9 pages, 3 figures, 1 table
Molecular evidence for multiple species of Oasisia (Annelida: Siboglinidae) at eastern Pacific hydrothermal vents
Creators: name: HURTADO, Luis A.
name: MATEOS, Mariana
name: LUTZ, Richard A.
name: VRIJENHOEK, Robert C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
Local probing of nuclear bath polarization with a single electronic spin
Creators: name: London, Paz
name: Fischer, Ran
name: Alvizu, Ignacio
name: Maze, Jeronimo R.
name: Gershoni, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate experimentally that a polarized nuclear spin modifies the dynamic behavior of a neighboring electronic spin. Specifically, an out-of-phase component appears in the electronic spin-echo signal. This component is proportional to the nuclear spin degree of polarization and strongly depends on the nuclear polarization direction. When the electronic spin is surrounded by a polarized nuclear spin bath, the spin-echo quadrature manifests a characteristic frequency related only to the nuclear spins abundance and their collective polarization. We use this analysis to propose a novel measurement method for the local nuclear spin bath of a single electronic spin. We quantify the realistic experimental regimes at which the scheme is efficient. Our proposal has potential applications for quantum sensing schemes, and opens a route for a systematic study of polarized mesoscopical-systems.
The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome
Creators: name: Bergstralh, Daniel T.
name: Taxman, Debra J.
name: Tze-Han Huang, Max
name: Holley-Guthrie, Elizabeth A.
name: Gris, Denis
name: Allen, Irving C.
name: Ting, Jenny Pan Yun
name: Moore, Chris B.
name: Lei, Yu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence indicates that ASC and these NLRs also elicit non-overlapping functions, but the molecular basis for this difference is unclear. To address this, we performed microarray and network analysis of ASC shRNA knockdown cells. In pathogen-infected cells, an ASC-dependent interactome is centered on the mitogen-activated protein kinase (MAPK) ERK and on multiple chemokines. ASC did not affect the expression of MAPK but affected its phosphorylation by pathogens and Toll-like receptor agonists via suppression of the dual-specificity phosphatase, DUSP10/MKP5. Chemokine induction, DUSP function, and MAPK phosphorylation were independent of caspase-1 and IL-1β. MAPK activation by pathogen was abrogated in Asc−/− but not Nlrp3−/−, Nlrc4−/−, or Casp1−/− macrophages. These results demonstrate a function for ASC that is distinct from the inflammasome in modulating MAPK activity and chemokine expression and further identify DUSP10 as a novel ASC target.
title: Corrosion des métaux employés dans la construction
Creators: name: Sereda, P. J.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1963
Subjects: subject: Corrosion (of reinforced concrete)
valueUri: urn:ircsubjects:IRC0743
subject: Corrosion de l'armature du béton
valueUri: urn:ircsubjects:IRC0743
subject: metal construction
subject: construction métallique
subject: corrosion
subject: rusting
subject: rouille
subject: steel
subject: acier
subject: ties ( reinforcement)
subject: traverse d'armature
subject: prestressed concrete
subject: béton précontraint
subject: water supply systems
subject: systèmes d'adduction d'eau
subject: piles
subject: pieu

description: Les problèmes auxquels la corrosion des métaux donne lieu sont extrêment variés. On trouvera dans le présent digeste un simple apercu de ces problèmes ainsi qu'un exposé des principes susceptibles d'aider les architectes à réduire le coût énorme de la corrosion.
(3967) James Robert Morton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The $Z_2$ Index of Disordered Topological Insulators with Time Reversal Symmetry
Creators: name: Katsura, Hosho
name: Koma, Tohru
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study disordered topological insulators with time reversal symmetry. Relying on the noncommutative index theorem which relates the Chern number to the projection onto the Fermi sea and the magnetic flux operator, we give a precise definition of the $Z_2$ index which is a noncommutative analogue of the Atiyah-Singer $Z_2$ index. We prove that the noncommutative $Z_2$ index is robust against any time-reversal symmetric perturbation including disorder potentials as long as the spectral gap at the Fermi level does not close.
description: 16 pages, no figure, v2: minor corrections, Appendix C and references added; v3: minor corrections
THREE NEW INTERSTITIAL GASTROTRICHS FROM ANDHRA COAST, INDIA
Creators: name: RAO, G. Chandrasekhara
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: The paper describes three new species of interstitial Gastrotrichs of the order Macrodasyoidea, collected in winter 1968 from the intertidal sands on Andhra coast (Bay of Bengal). They are Macrodasys hexadactylus n. sp., Paraturbanella mesop- tera n. sp., and Pseudostomella indica n. sp. The distribution of these forms in relation to the nature of the substratum, has also been reported.
The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1
Creators: name: Lavie, Arnon
name: Lye, Ming F.
name: Fanning, Alan S.
name: Nomme, Julian
name: Caffrey, Michael
name: Anderson, James M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Tight junctions are cell-cell contacts that regulate the paracellular flux of solutes and prevent pathogen entry across cell layers. The assembly and permeability of this barrier are dependent on the zonula occludens (ZO) membrane-associated guanylate kinase (MAGUK) proteins ZO-1, -2, and -3. MAGUK proteins are characterized by a core motif of protein-binding domains that include a PDZ domain, a Src homology 3 (SH3) domain, and a region of homology to guanylate kinase (GUK); the structure of this core motif has never been determined for any MAGUK. To better understand how ZO proteins organize the assembly of protein complexes we have crystallized the entire PDZ3-SH3-GUK core motif of ZO-1. We have also crystallized this core motif in complex with the cytoplasmic tail of the ZO-1 PDZ3 ligand, junctional adhesion molecule A (JAM-A) to determine how the activity of different domains is coordinated. Our study shows a new feature for PDZ class II ligand binding that implicates the two highly conserved Phe−2 and Ser−3 residues of JAM. Our x-ray structures and NMR experiments also show for the first time a role for adjacent domains in the binding of ligands to PDZ domains in the MAGUK proteins family.
title: Résistance des petites toitures
Creators: name: Schriever, W. R.
name: Thorburn, H. J.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1963
Subjects: subject: Snow and Ice loads
valueUri: urn:ircsubjects:IRC0373
subject: Surcharges neige et glace
valueUri: urn:ircsubjects:IRC0373
subject: Wind loads
valueUri: urn:ircsubjects:IRC0372
subject: Surcharges vent
valueUri: urn:ircsubjects:IRC0372
subject: roofing
subject: couvertures
subject: roofs
subject: toiture
subject: roof framing
subject: charpente
subject: roof trusses
subject: ferme (charpente)
subject: wood frame construction
subject: construction à ossature de bois
subject: snow loads
subject: charge de neige
subject: wind loads
subject: surcharges de vent
subject: design loads
subject: charge utile

description: La solidité exigée des petits toits dépend des charges auxquelles ils doivent résister et du degré de sûreté qu'on désire. L'obtention de la solidité ainsi définie dépend en grande partie de l'efficacité des éléments employés. Cette efficacité dépend elle-même non seulement de la résistance des membrures mais aussi de la résistance des raccords.
Understanding Financial Market States Using Artificial Double Auction Market
Creators: name: Yim, Kyubin
name: Oh, Gabjin
name: Kim, Seunghwan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: FOS: Economics and business

description: The ultimate value of theories of the fundamental mechanisms comprising the asset price in financial systems will be reflected in the capacity of such theories to understand these systems. Although the models that explain the various states of financial markets offer substantial evidences from the fields of finance, mathematics, and even physics to explain states observed in the real financial markets, previous theories that attempt to fully explain the complexities of financial markets have been inadequate. In this study, we propose an artificial double auction market as an agent-based model approach to study the origin of complex states in the financial markets, characterizing important parameters with an investment strategy that can cover the dynamics of the financial market. The investment strategy of chartist traders after market information arrives should reduce market stability originating in the price fluctuations of risky assets. However, fundamentalist traders strategically submit orders with a fundamental value and, thereby stabilize the market. We construct a continuous double auction market and find that the market is controlled by a fraction of chartists, P_{c}. We show that mimicking real financial markets state, which emerges in real financial systems, is given between approximately P_{c} = 0.40 and P_{c} = 0.85, but that mimicking the efficient market hypothesis state can be generated in a range of less than P_{c} = 0.40. In particular, we observe that the mimicking market collapse state created in a value greater than P_{c} = 0.85, in which a liquidity shortage occurs, and the phase transition behavior is P_{c} = 0.85.
description: 17 pages, 10 figures
title: MDSuite : comprehensive post-processing tool for particle simulations
Creators: name: Tovey, Samuel
name: Zills, Fabian
name: Torres-Herrador, Francisco
name: Lohrmann, Christoph
name: Brückner, Marco
name: Holm, Christian
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 530
subject: 004

description: Particle-Based (PB) simulations, including Molecular Dynamics (MD), provide access to system observables that are not easily available experimentally. However, in most cases, PB data needs to be processed after a simulation to extract these observables. One of the main challenges in post-processing PB simulations is managing the large amounts of data typically generated without incurring memory or computational capacity limitations. In this work, we introduce the post-processing tool: MDSuite. This software, developed in Python, combines state-of-the-art computing technologies such as TensorFlow, with modern data management tools such as HDF5 and SQL for a fast, scalable, and accurate PB data processing engine. This package, built around the principles of FAIR data, provides a memory safe, parallelized, and GPU accelerated environment for the analysis of particle simulations. The software currently offers 17 calculators for the computation of properties including diffusion coefficients, thermal conductivity, viscosity, radial distribution functions, coordination numbers, and more. Further, the object-oriented framework allows for the rapid implementation of new calculators or file-readers for different simulation software. The Python front-end provides a familiar interface for many users in the scientific community and a mild learning curve for the inexperienced. Future developments will include the introduction of more analysis associated with ab-initio methods, colloidal/macroscopic particle methods, and extension to experimental data.
A Ring of C2H in the Molecular Disk Orbiting TW Hya
Creators: name: Kastner, Joel H.
name: Qi, Chunhua
name: Gorti, Uma
name: Hily-Blant, Pierre
name: Oberg, Karin
name: Forveille, Thierry
name: Andrews, Sean
name: Wilner, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have used the Submillimeter Array to image, at ~1.5" resolution, C2H (3-2) emission from the circumstellar disk orbiting the nearby (D = 54 pc), ~8 Myr-old, ~0.8 Msun classical T Tauri star TW Hya. The SMA imaging reveals that the C2H emission exhibits a ring-like morphology. Based on a model in which the C2H column density follows a truncated radial power-law distribution, we find that the inner edge of the ring lies at ~45 AU, and that the ring extends to at least ~120 AU. Comparison with previous (single-dish) observations of C2H (4-3) emission indicates that the C2H molecules are subthermally excited and, hence, that the emission arises from the relatively warm, tenuous upper atmosphere of the disk. We propose that the C2H emission most likely traces particularly efficient photo-destruction of small grains and/or photodesorption and photodissociation of hydrocarbons derived from grain ice mantles in the surface layers of the outer disk. The presence of a C2H ring in the TW Hya disk hence likely serves as a marker of dust grain processing and radial and vertical grain size segregation within the disk.
description: 17 pages, 4 figures; to appear in The Astrophysical Journal
Distribution and mortality of the Mediterranean Stony Coral (Cladocora caespitosa Linnaeus, 1767) around Gökçeada Island (Northern Aegean Sea)
Creators: name: GÜREŞEN, Sedat Ozan
name: TOPÇU, Nur Eda
name: ÖZTÜRK, Bayram
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Cladocora caespitosa colonies around Gökçeada Island had discrete and scattered distribution with regional density of 0.12 colonies.m-2 and a mean cover of 0.27%. The size frequency distribution of the colonies showed a prevalence of small sizes, possibly related to frequent storm events. About 15% of the colonies were affected by mortality, of which 67% were recently dead, probably due to positive thermal anomalies. This is the first report of mortality of this species from the Aegean Sea and from the Turkish coasts. Considering the vulnerability of the species to climate change and harvesting in the island, we suggest that C. caespitosa should be included in the list of species completely prohibited to harvest according to the statements 2012/66 and 2012/65 of Turkish law.
The Tumor Suppressor Activity of the Transmembrane Protein with Epidermal Growth Factor and Two Follistatin Motifs 2 (TMEFF2) Correlates with Its Ability to Modulate Sarcosine Levels
Creators: name: Asch, Adam S.
name: Green, Thomas
name: Overcash, Ryan
name: Ruiz-Echevarría, Maria J.
name: Chen, Xiaofei
name: Hoffman, Donald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The type I transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is expressed in brain and prostate and overexpressed in prostate cancer, but its role in this disease is unclear. Several studies have suggested that TMEFF2 plays a role in suppressing the growth and invasive potential of human cancer cells, whereas others suggest that the shed portion of TMEFF2, which lacks the cytoplasmic region, has a growth-promoting activity. Here we show that TMEFF2 has a dual mode of action. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. However, expression of the ectodomain portion of TMEFF2 increases cell proliferation. Using affinity chromatography and mass spectrometry, we identify sarcosine dehydrogenase (SARDH), the enzyme that converts sarcosine to glycine, as a TMEFF2-interacting protein. Co-immunoprecipitation and immunofluorescence analysis confirms the interaction of SARDH with full-length TMEFF2. The ectodomain does not bind to SARDH. Moreover, expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells. These results suggest that the tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine.
title: Composés de colmatage des joints
Creators: name: Gibbons, E. V.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1963
Subjects: subject: Buildings
valueUri: urn:ircsubjects:IRC0721
subject: Bâtiments
valueUri: urn:ircsubjects:IRC0721
subject: filling (jointing)
subject: colmatage
subject: sealants
subject: mastic
subject: putty

description: Ce digeste décrit la composition et les propriétés de certains composés de colmatage, passe en revue quelques méthodes d'essai, et fait des recommandations sur la facon d' appliquer les composés.
Superconductivity in Weyl Semimetal Candidate MoTe2
Creators: name: Qi, Yanpeng
name: Naumov, Pavel G.
name: Ali, Mazhar N.
name: Rajamathi, Catherine R.
name: Barkalov, Oleg
name: Hanfland, Michael
name: Wu, Shu-Chun
name: Shekhar, Chandra
name: Sun, Yan
name: Süß, Vicky
name: Schmidt, Marcus
name: Pippel, Eckhard
name: Werner, Peter
name: Hillebrand, Reinald
name: Förster, Tobias
name: Kampertt, Erik
name: Schnelle, Walter
name: Parkin, Stuart
name: Cava, R. J.
name: Felser, Claudia
name: Yan, Binghai
name: Medvedev, Sergiy A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In recent years, layered transition-metal dichalcogenides (TMDs) have attracted considerable attention because of their rich physics; for example, these materials exhibit superconductivity, charge density waves, and the valley Hall effect. As a result, TMDs have promising potential applications in electronics, catalysis, and spintronics. Despite the fact that the majority of related research focuses on semiconducting TMDs (e.g., MoS2), the characteristics of WTe2 are provoking strong interest in semimetallic TMDs with extremely large magnetoresistance, pressure-driven superconductivity, and the predicted Weyl semimetal (WSM) state. In this work, we investigate the sister compound of WTe2, MoTe2, which is also predicted to be a WSM and a quantum spin Hall insulator in bulk and monolayer form, respectively. We find that MoTe2 exhibits superconductivity with a resistive transition temperature Tc of 0.1 K. The application of a small pressure (such as 0.4 GPa) is shown to dramatically enhance the Tc, with a maximum value of 8.2 K being obtained at 11.7 GPa (a more than 80-fold increase in Tc). This yields a dome-shaped superconducting phase diagram. Further explorations into the nature of the superconductivity in this system may provide insights into the interplay between strong correlations and topological physics.
description: 20 pages, 5 figures
title: Genome-wide deposition of 6-methyladenine in human DNA reduces the viability of HEK293 cells and directly influences gene expression
Creators: name: Broche, Julian
name: Köhler, Anja R.
name: Kühnel, Fiona
name: Osteresch, Bernd
name: Chandrasekaran, Thyagarajan T.
name: Adam, Sabrina
name: Brockmeyer, Jens
name: Jeltsch, Albert
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 570
subject: 540

description: While cytosine-C5 methylation of DNA is an essential regulatory system in higher eukaryotes, the presence and relevance of 6-methyladenine (m6dA) in human cells is controversial. To study the role of m6dA in human DNA, we introduced it in human cells at a genome-wide scale at GANTC and GATC sites by expression of bacterial DNA methyltransferases and observed concomitant reductions in cell viability, in particular after global GANTC methylation. We identified several genes that are directly regulated by m6dA in a GANTC context. Upregulated genes showed m6dA-dependent reduction of H3K27me3 suggesting that the PRC2 complex is inhibited by m6dA. Genes downregulated by m6dA showed enrichment of JUN family transcription factor binding sites. JUN binds m6dA containing DNA with reduced affinity suggesting that m6dA can reduce the recruitment of JUN transcription factors to target genes. Our study documents that global introduction of m6dA in human DNA has physiological effects. Furthermore, we identified a set of target genes which are directly regulated by m6dA in human cells, and we defined two molecular pathways with opposing effects by which artificially introduced m6dA in GANTC motifs can directly control gene expression and phenotypes of human cells.
Complex Organic and Inorganic Compounds in Shells of Lithium-rich K Giant Stars
Creators: name: de la Reza, Ramiro
name: Drake, Natalia A.
name: Oliveira, Isa
name: Rengaswamy, Sridharan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Hydrocarbon organic material, as found in the interstellar medium, exists in complex mixtures of aromatic and aliphatic forms. It is considered to be originated from carbon enriched giant stars during their final stages of evolution, when very strong mass loss occurs in a few thousand years on their way to become planetary nebulae. We show here that the same organic compounds appear to be formed in previous stages of the evolution of giant stars. More specifically, during the first ascending giant branch K-type stars. According to our model this happens only when these stars are being abruptly enriched with lithium together with the formation of a circumstellar shell with a strong mass loss during just a few thousand years. This sudden mass loss is, on an average, a thousand times larger than that of normal Li-poor K giant stars. This shell would later be detached, specially when the star stops its Li enrichment and a rapid photospheric Li depletion occurs. In order to gain extra carbon-based material to form the organic hydrocarbons, and also to explain the presence of complex inorganic compounds in these stars, we propose an interaction of these strong winds with remaining asteroidal/cometary disks that already existed around these stars since they were dwarf A-type stars. The mechanism of interaction presented here is successful to explain the presence of inorganic compounds, however it is unable to produce new carbon free atoms to form the organic hydrocarbon compounds. Finally, we discuss some suggestions and speculations that can eventually help solving the long-standing puzzle of Li-rich giants.
description: Accepted for publication in ApJ, 19 pages, 5 figures, 1 table
Feasibility and acceptability of SEPA+PrEP: An HIV prevention intervention to increase PrEP knowledge, initiation, and persistence among cisgender heterosexual Hispanic women
Creators: name: Peragallo-Montano N.
name: Villegas N.
name: Baeza M.J.
name: Cianelli R.
name: Thomas S.O.
name: De Oliveira G.C.
name: Castro J.G.
name: De Santis J.P.
name: Iriarte E.
Publisher: name: Public Library of Science
Year: 2024

description: The HIV epidemic disproportionately affects Hispanics in the U.S., with Hispanic women (HW) accounting for 18% of new HIV diagnoses in 2019 despite comprising only 16% of the female population. The imbalance of power related to cultural values and HW’s lack of knowledge and low perception of risk for HIV interferes with prevention efforts (e.g., condom use, HIV testing, and Pre-Exposure Prophylaxis [PrEP]). It is estimated that in 2019, only 10% of women in the U.S. who could benefit from PrEP were given prescriptions for it. This number is estimated to be significantly lower among HW. PrEP is highly effective for preventing HIV, reducing the risk of acquiring HIV from sexual activity by about 99%. To respond to this need, we developed SEPA+PrEP, a biobehavioral HIV prevention intervention that adapted and integrated SEPA (Salud/Health, Educación/Education, Prevención/ Prevention, Autocuidado/Self-Care), an empirically validated behavioral HIV prevention intervention, with the evidence-based biomedical strategy of PrEP. This study aimed to investigate the feasibility and acceptability of SEPA+PrEP among cisgender heterosexual Hispanic women (HW). We used a mixed methods approach to gather data from 44 HW living in the City of Homestead and its surrounding communities in Miami-Dade County, Florida. None of the participants knew about PrEP prior to participating in the study, and the majority (70.5%, n = 23) had not used condoms when engaging in vaginal sex during the previous three months. Overall, study results suggest that SEPA+PrEP is an acceptable and feasible intervention to prevent HIV among HW, with a focus on PrEP knowledge, initiation, and maintenance.
title: Solar heat gain through glass walls
Creators: name: Stephenson, D. G.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1963
Subjects: subject: Heat performance
valueUri: urn:ircsubjects:IRC0391
subject: Performance thermique
valueUri: urn:ircsubjects:IRC0391
subject: solar heating
subject: chauffage solaire
subject: heat gains
subject: apport de chaleur
subject: glass (materials)
subject: verre (matériau)
subject: windows
subject: fenêtre

description: Solar heat gain can be substantially reduced by orienting a building so that there is a minimum of glass in the east and west facades. Solar heat gain through south facing windows can be controlled during the summer by outside shades or by tilting; if they are double glazed such windows do not increase the energy requirements for heating in the southern part of Canada. Heat gain in the east or west facades can be reduced by using double glazing. Finally blinds can be used to reduce solar heating.
(3964) William Gray Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Corrigendum to "Classifying C*-algebras with both finite and infinite subquotients"
Creators: name: Eilers, Søren
name: Restorff, Gunnar
name: Ruiz, Efren
Publisher: name: arXiv
Year: 2015
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: As recently pointed out by Gabe, a fundamental paper by Elliott and Kucerovsky concerning the absorption theory for C*-algebras contains an error, and as a consequence we must report that Lemma 4.5 in "Classifying C*-algebras with both finite and infinite subquotients" J. Funct. Anal. 265 (2013), no. 3, 449--468 is not true as stated. In this corrigendum, we prove an adjusted statement and explain why the error has no consequences to the main results of that paper. In particular, it is noted that all the authors' claims concerning Morita equivalence or stable isomorphism of graph C*-algebras remain correct as stated.
description: 5 pages
ON PSEUDOSTOMELLA SWEDMARK 1956 WITH DESCRIPTIONS OF P. PLUMOSA NOV. SPEC., P. CATAPHRACTA NOV. SPEC., AND A FORM OF P. ROSCOVITA SWEDMARK 1956 FROM THE WEST ATLANTIC COAST
Creators: name: RUPPERT, Edward E.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: Two new species of the genus Pseudostomella are described. P. plumosa nov. spec, is distinguished by a covering of stalked scales, a unique feature in the Macrodasyoidea. P. cataphracta nov spec, is characterized by a covering of small pentancres. A Carolina form of P. roscovita Swedmark 1956 is described and the necessity of making more detailed descriptions is discussed. Diagnoses for all the known forms and species of the genus are given and a key is presented.A ll specimens were taken in samples along the coast of North Carolina.
The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties
Creators: name: Burridge, Keith
name: Campbell, Sharon L.
name: Swaminathan, Vinay S.
name: Shen, Kai
name: Guilluy, Christophe
name: Tolbert, Caitlin E.
name: Berginski, Matthew E.
name: Superfine, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Vinculin is an essential and highly conserved cell adhesion protein, found at both focal adhesions and adherens junctions, where it couples integrins or cadherins to the actin cytoskeleton. Vinculin is involved in controlling cell shape, motility, and cell survival, and has more recently been shown to play a role in force transduction. The tail domain of vinculin (Vt) contains determinants necessary for binding and bundling of actin filaments. Actin binding to Vt has been proposed to induce formation of a Vt dimer that is necessary for cross-linking actin filaments. Results from this study provide additional support for actin-induced Vt self-association. Moreover, the actin-induced Vt dimer appears distinct from the dimer formed in the absence of actin. To better characterize the role of the Vt strap and carboxyl terminus (CT) in actin binding, Vt self-association, and actin bundling, we employed smaller amino-terminal (NT) and CT deletions that do not perturb the structural integrity of Vt. Although both NT and CT deletions retain actin binding, removal of the CT hairpin (1061–1066) selectively impairs actin bundling in vitro. Moreover, expression of vinculin lacking the CT hairpin in vinculin knock-out murine embryonic fibroblasts affects the number of focal adhesions formed, cell spreading as well as cellular stiffening in response to mechanical force.
Unambiguous Characterization of Site-specific Phosphorylation of Leucine-rich Repeat Fli-I-interacting Protein 2 (LRRFIP2) in Toll-like Receptor 4 (TLR4)-mediated Signaling
Creators: name: Gunawardena, Harsha P.
name: Kenjale, Roma
name: Wang, Haiyang
name: Xie, Ling
name: Chen, Xian
name: Huang, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: In the TLR4 signaling pathways, we previously characterized a signal regulator, LRRFIP2, that modulates the time course-dependent changes in NF-κB activity through its dynamic interaction with the TLR adaptor protein, MyD88. However, little is known about the driving force behind the LPS-inducible dynamics between LRRFIP2 and MyD88. We have therefore designed a multiplex label-free quantitative proteomics method to investigate dynamic changes of LRRFIP2 phosphorylation upon LPS stimulation. Given our observation that LRRFIP2 binds to MyD88 through its serine-rich domain in which most of serine residues have the propensity to be phosphorylated, we used collision-activated dissociation- and electron transfer dissociation-based methods in a complementary manner to unambiguously localize phosphorylation sites in the peptides constituting the serine-rich domain. Among 23 phosphorylation sites identified and first quantified by the label-free approach and then verified by the AACT/SILAC (amino acid-coded tagging/stable isotope labeling in cell culture)-based quantitation method, phosphorylation at serine 202 showed a significant LPS-induced dynamic change during the full-course cellular response to LPS stimulation. The substitution of serine 202 with nonphosphorylated residues by site-directed mutagenesis resulted in a weakened LRRFIP2-MyD88 interaction and a concurrently reduced activity in downstream NF-κB. Taking these results together, phosphorylation at serine 202 was found to regulate the dynamics of the LRRFIP2-MyD88 interaction, which in turn modulated the strength and duration of TLR4 signaling. Strategically, we have demonstrated the importance of precise identification of the biologically relevant phosphorylation site(s) using comprehensive mass spectrometry-based quantitative proteomics approaches in guiding downstream biological characterization experiments, which could otherwise be both time- and cost-consuming for a large number of phosphorylation possibilities.