cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A phase I trial of everolimus in combination with 5-FU/LV, mFOLFOX6 and mFOLFOX6 plus panitumumab in patients with refractory solid tumors
Creators: name: McRee, Autumn J.
name: Ivanova, Anastasia
name: Sanoff, Hanna G.
name: Bernard, Stephen
name: Goldberg, Richard M.
name: O'Neil, Bert H.
name: Davies, Janine M.
name: Claire Dees, E.
name: Keller, Kimberly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: This phase I study investigated the safety, dose limiting toxicity, and efficacy in three cohorts all treated with the mTOR inhibitor everolimus that was delivered 1) in combination with 5-fluourouracil with leucovorin (5-FU/LV), 2) with mFOLFOX6 (5-FU/LV + Oxaliplatin), and 3) with mFOLFOX6 + panitumumab in patients with refractory solid tumors.
Allied health assistant management of people with hip fracture is feasible and may improve patient adherence to hip fracture mobilisation guidelines: a feasibility randomised controlled trial
Creators: name: Snowdon, David
name: Vincent, P
name: Callisaya, ML
name: Collyer, TA
name: Brusco, Natasha
name: Wang, YT
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 4201
subject: Allied health and rehabilitation science

description: Objectives: Determine the feasibility of allied health assistant (AHA) management of people with hip fracture an acute hospital. Design: Assessor-blind, parallel, feasibility randomised controlled trial with qualitative component. Setting: Acute orthopaedic ward. Participants: People with surgically-managed hip fracture, who walked independently pre-fracture and had no cognitive impairment. Interventions: Rehabilitation from an AHA, under the supervision of a physiotherapist, compared with rehabilitation from a physiotherapist. Main outcome measures: Feasibility was evaluated according to focus areas of demand, acceptability, practicality and implementation. Secondary outcomes included estimates of effect of adherence to hip fracture mobilisation guidelines, discharge destination, 30-day readmission, functional activity, and length of stay. Results: Fifty people were allocated to receive rehabilitation from an AHA (n = 25) or physiotherapist (n = 25). AHA rehabilitation had high demand with 60% of eligible participants recruited. Satisfaction with AHA rehabilitation was comparable with physiotherapy rehabilitation (acceptability). The AHA group received an average of 11 min (95% CI 4 to 19) more therapy per day than the physiotherapy group (implementation). The AHA group may have had lower cost of acute care (MD -$3 808 95% CI −7 651 to 35) and adverse events were comparable between groups (practicality). The AHA group may have been 22% (HR 1.22, 95% CI 0.92 to 1.61) more likely to walk on any day and may have had a shorter length of stay (MD −0.8 days, 95% CI −2.3 to 0.7). Conclusions: AHA management of patients with hip fracture was feasible and may improve adherence to mobilisation guidelines and reduce cost of care and length of stay. Clinical Trial Registration Number: ACTRN12620000877987. Contribution of the paper: • It is feasible for allied health assistants, under the supervision of a physiotherapist, to manage the acute care of people with hip fracture who walked independently pre-fracture and had no cognitive impairment. • Delegating acute management of people with hip fracture to allied health assistants may improve adherence to hip fracture mobilisation guidelines and reduce length of stay and cost of acute care, however, further trials are needed to confirm these effects.
ESM_Primate trichromacy and colour signals from Experimental evidence that primate trichromacy is well suited for detecting primate social colour signals.
Creators: name: Hiramatsu, Chihiro
name: Melin, Amanda D.
name: Allen, William L.
name: Dubuc, Constance
name: Higham, James P.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Supplementary Information of Hiramatsu et al_Primate trichromacy and colour signals
(401876) Jane [Roy]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Creators: name: Stanford, Janet L.
name: Farin, Federico M.
name: Wideroff, Louise
name: Risch, Harvey
name: Gammon, Marilie D.
name: Vaughan, Thomas L.
name: Chow, Wong Ho
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: In a population-based case-control study in the U.S., we examined risks of histologically confirmed esophageal and gastric adenocarcinomas in relation to polymorphisms of the following genes: GSTP; GSTM1; GSTT1; NAT1; and CYP1A1. For the GSTP1 Val/Val genotype (vs. Ile/Ile), the respective ORs of esophageal, cardia, and other gastric adenocarcinomas were 1.73 (0.75–4.02), 1.46 (0.57–3.73), and 1.22 (0.48–3.09), while no consistent patterns of elevated risk were associated with the null GSTM1 or GSTT1 genotypes, one or two copies of NAT1*10 or *11 alleles, or CYP1A1 Val/Val or Ile/Val genotypes (vs. Ile/Ile).
(401877) James Thomson Stuart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Nothing has changed. The wrong term “superficial femoral vein” is still in use.
Creators: name: Cokkinos, Demosthenes
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Ultrasound-Spectral Doppler
subject: Education
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To find out if the term “superficial femoral vein” is still in use. To discourage improper use of vascular terminology of lower extremity...
(401873) John Harry Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401874) Harry Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck
Creators: name: Sullivan, Patrick F.
name: Olshan, Andrew F.
name: Basta, Patricia V.
name: Bensen, Jeannette T.
name: Perou, Charles M.
name: Tse, Chiu Kit
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The Pentose Phosphate Pathway (PPP) is involved in the body’s protection against oxidative stress and resistance/susceptibility to apoptosis and thus has been implicated in tumor development and progression. Here we present data examining the association of genetic variation in one of the key enzymes of the PPP, Transaldolase 1 (TALDO1) with squamous cell carcinoma of the head and neck (SCCHN).
The role of professional training in the valorisation of human capital
Creators: name: Bertani, Michele
Publisher: name: QuiEdit
Year: 2015
Subjects: human capital; professional training; labour market

description: The aim of this article is to monitor the outcome of professional training courses programmed in the Veneto Region, the potential, positive repercussions on the labour market and, consequently, on the wellbeing of the community. By means of the human capital concept, it can be evaluated if those students, who successfully finished their professional training courses, were able to see if their training curriculum had been suitably valorised, which was achieved by being able to start work in line with their qualifications, both quickly and positively, they had obtained. Using the data derived from the widespread network of training agencies present in theVeneto, the quantitative and qualitative characteristics of the courses have been analysed, subsequently identifying the profiles of those who qualified and their outcome in gaining access to the labour market.
description: Italian Sociological Review, Vol 1, No 2 (2011)
title: Разработка инструментов адаптации персонала на основе исследований и психологических экспериментов в целях гуманизации трудовой деятельности
title: Development of Personnel Adaptation Tools Based on the Research and Psychological Experiments to Humanize Labor Activity
Creators: name: Чуланова, Оксана Леонидовна
name: Абдернасирова, Алина Аскаровна
Publisher: name: Издательский центр СурГУ
Year: 2022

description: Представлены результаты авторского исследования разработки инструментария адаптации персонала с применением опыта психологических исследований для гуманизации трудовой деятельности и профилактики буллинга и моббинга на рабочих местах, проведен анализ возможностей и рисков применения результатов психологических экспериментов (теории разбитых окон, экспериментов Зимбардо и Милгрэма) в адаптации и развитии персонала в организации. Рассмотрены возможности созданного авторами Telegram-канала Psychological Self Help для помощи в идентификации состояния сотрудников, позволяющего оценить профессиональное выгорание, эмоциональный интеллект, социальный интеллект, склонность к деструктивному поведению, уровень тревожности, удовлетворенность условиями труда; определить стиль управления, уровень профессиональной мотивации, манипулятивные наклонности, тип личности и взаимодействие между типами личности на основе деловой соционики.
description: The article presents the results of the author’s research on developing an adapting apparatus for personnel with applying practice from psychological studies. The apparatus aims at humanization of working activity and prevention of bulling and mobbing of personnel at the work place. The authors conducted an analysis of possibilities and risks of applying results of psychological experiments (theory of Broken Windows, Stanford prison experiment, Milgram experiment) in personnel adaptation and improvement in organization. The article shows the possibilities of the author’s Telegram-channel, Psychological Self Help, that helps determine the personnel’s state. The channel allows authors to evaluate the occupational burnout, emotional intelligence, social intelligence, tendency towards destructive attitude, anxiety level, satisfaction with work conditions; determine the management style, level of professional motivation, manipulative tendency, type of personality and interrelation between types of personality based on the business socionics.
Factors associated with annual-interval mammography for women in their 40s
Creators: name: DeFrank, Jessica T.
name: Skinner, Celette Sugg
name: Bowling, J. Michael
name: Gierisch, Jennifer M.
name: Rimer, Barbara K.
name: O'Neill, Suzanne C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Evidence is mounting that annual mammography for women in their 40s may be the optimal schedule to reduce morbidity and mortality from breast cancer. Few studies have assessed predictors of repeat mammography on an annual interval among these women.
title: Dose reduction in thoracic spine imaging with different lead shielding and field collimation options
Creators: name: Viltužnik, Rebeka
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal spine
subject: Digital radiography
subject: Safety
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The influence of beam collimation and shielding options on absorbed dose in thoracic spine X-rays, was...
A Study of Shell Model Neutron States in $^{207,209}Pb$ Using the Generalized Woods-Saxon plus Spin-Orbit Potential
Creators: name: Liendo, J. A.
name: Castro, E.
name: Gómez, R.
name: Caussyn, D. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The experimental binding energies of single-particle and single-hole neutron states belonging to neutron shells that extend from N = 126 to 184 and 82 to 126 respectively, have been reproduced by solving the Schrödinger equation with a potential that has two components: the generalized Woods-Saxon (GWS) potential and the spin-orbit (SO) coupling term. The GWS potential contains the traditional WS potential plus a term (SU) whose intensity reaches a maximum in the nuclear surface. Our results indicate the existence of a explicit relationship between the strength of the SU potential and the orbital angular momentum quantum number $\ell$ of the state. This dependence has been used to make reasonable predictions for the excitation energy centroids of states located inside and outside the neutron shells investigated. Comparisons are made with results reported in previous investigations.
High prevalence of cervical squamous intraepithelial lesions in women on antiretroviral therapy in Cameroon: Is targeted screening feasible?
Creators: name: Smith, Jennifer S.
name: Myers, Evan
name: Eron, Joseph
name: Miller, William C.
name: Ikomey, George M.
name: Atashili, Julius
name: Adimora, Adaora A.
name: Rinas, Allen C.
name: Ndumbe, Peter M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Cervical cancer is the most common cancer in women in low-income countries. Although cervical cancer incidence and mortality is higher in HIV-positive women, resource limitations restrict the implementation of systematic screening programs in these women. We explored the potential for targeted screening by assessing the prevalence, severity and predictors of cervical squamous intra-epithelial lesions (SILs) in HIV-positive women in Cameroon.
title: Posterior fossa malformations- One Mega-bite at a time.
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: CNS
subject: Foetal imaging
subject: CT
subject: MR
subject: Ultrasound
subject: Comparative studies
subject: Complications
subject: Congenital
subject: Cysts
subject: Foetus

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To discuss the various posterior fossa malformations, focusing on neuroimaging findings and neurologic...
Reflections on the meaning of the book, beginning with its physicality: instrument or fetish?
Creators: name: Pozzi, Alessandra
Publisher: name: QuiEdit
Year: 2015
Subjects: Book as object; Practice of reading and writing; Fetish

description: Questioning the meaning of the book as an object today, when faced with the use of digital and multimedia devices, also entails reasoning about the meaning attributed to the physicality of the encounter with a paper object. In this sense, the book is not only represented as an “instrument” for accessing knowledge, but also as an object that implies forms of “ritual” and reflections on the concept of “sacredness”, until it becomes almost a “fetish” (therefore profane) involved in the construction of the Self and symbolically a sign of  “late modernity”.
description: Italian Sociological Review, Vol 1, No 2 (2011)
The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
Creators: name: Vaughan, Thomas L.
name: Bernstein, Leslie
name: Lubin, Jay H.
name: Chow, Wong Ho
name: Wu, Anna H.
name: Sharp, Linda
name: Ward, Mary H.
name: Giffen, Carol
name: Gammon, Marilie D.
name: Webb, Penelope M.
name: Casson, Alan G.
name: Kamangar, Farin
name: Murray, Liam J.
name: Pandeya, Nirmala
name: Abnet, Christian C.
name: Freedman, Neal D.
name: Cook, Michael B.
name: Nyrén, Olof
name: Brown, Linda M.
name: Whiteman, David C.
name: Corley, Douglas A.
name: Ye, Weimin
name: Risch, Harvey A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Cigarette smoking is associated with esophageal adenocarcinoma (EAC), esophagogastric junctional adenocarcinoma (EGJA) and esophageal squamous cell carcinoma (ESCC), and alcohol consumption with ESCC. However, no analyses have examined how delivery rate modifies the strength of odds ratio (OR) trends with total exposure, i.e., the impact on the OR for a fixed total exposure of high exposure rate for short duration compared with low exposure rate for long duration.
Microscopic insight on the pump-probe relaxation dynamics of superconductors: Model study of MgB2 relaxation within nonlinear response theory
Creators: name: Baňacký, Pavol
name: Szöcs, Vojtech
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Here we present a quantum-statistical formulation of third-order polarization P(3)(t), which is induced in a sample by a sequence of incident external fields, and serves as a source of an emitted radiation field detected as a signal in pump-probe (PP) experiments. Our treatment is based on the perturbation expansion of the non-equilibrium density matrix for calculation of multi-time correlation functions, and the corresponding response function, at finite temperature. As a model for our study, the high-temperature superconductor MgB2 has been selected. Knowledge of the electronic structure of the studied system, and of the corresponding Eliashberg function that represents pertinent electron-phonon (EP) interactions, enabled us to distinguish non-equilibrium processes running over different time-periods in a sequence of interactions with laser pulses on a microscopic level. We have also derived temperature-dependent relaxation dynamics as a function of delay time between the pump and probe pulses. For the studied model system of MgB2, we have shown that an abrupt increase of the relaxation time at Tc, as detected by experiments, is the direct consequence of sudden changes in the character of EP coupling in transition from an adiabatic to a stabilized superconducting anti-adiabatic state, as it predicts the anti-adiabatic theory of electron-vibration interactions. The BCS model, which preserves the adiabatic character of EP coupling also below the critical temperature of MgB2, is basically unable to reflect the enormous sudden increase of the relaxation time. Based on diagrammatic perturbation theory, differences in the optical pump-optical probe and the optical pump-terahertz probe settings of MgB2 PP relaxation dynamics are discussed.
description: 21 pages of the main text with 5 Figures and supplemental material in the form of Appendices A-E
ESM_Primate trichromacy and colour signals from Experimental evidence that primate trichromacy is well suited for detecting primate social colour signals
Creators: name: Hiramatsu, Chihiro
name: Melin, Amanda D.
name: Allen, William L.
name: Dubuc, Constance
name: Higham, James P.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Supplementary Information of Hiramatsu et al_Primate trichromacy and colour signals
The Generalized Legendre transform and its applications to inverse spectral problems
Creators: name: Guillemin, Victor
name: Wang, Zuoqin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Spectral Theory (math.SP)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 35P20, 53D20

description: Let $M$ be a Riemannian manifold, $τ: G \times M \to M$ an isometric action on $M$ of an $n$-torus $G$ and $V: M \to \mathbb R$ a bounded $G$-invariant smooth function. By $G$-invariance the Schrödinger operator, $P=-\hbar^2 Δ_M+V$, restricts to a self-adjoint operator on $L^2(M)_{α/\hbar}$, $α$ being a weight of $G$ and $1/\hbar$ a large positive integer. Let $[c_α, \infty)$ be the asymptotic support of the spectrum of this operator. We will show that $c_α$ extend to a function, $W: \mathfrak g^* \to \mathbb R$ and that, modulo assumptions on $τ$ and $V$ one can recover $V$ from $W$, i.e. prove that $V$ is spectrally determined. The main ingredient in the proof of this result is the existence of a "generalized Legendre transform" mapping the graph of $dW$ onto the graph of $dV$.
description: 23 pages
Thermoelectricity without absorbing energy from the heat sources
Creators: name: Whitney, Robert. S.
name: Sánchez, Rafael
name: Haupt, Federica
name: Splettstoesser, Janine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We analyze the power output of a quantum dot machine coupled to two electronic reservoirs via thermoelectric contacts, and to two thermal reservoirs - one hot and one cold. This machine is a nanoscale analogue of a conventional thermocouple heat-engine, in which the active region being heated is unavoidably also exchanging heat with its cold environment. Heat exchange between the dot and the thermal reservoirs is treated as a capacitive coupling to electronic fluctuations in localized levels, modeled as two additional quantum dots. The resulting multiple-dot setup is described using a master equation approach. We observe an "exotic" power generation, which remains finite even when the heat absorbed from the thermal reservoirs is zero (in other words the heat coming from the hot reservoir all escapes into the cold environment). This effect can be understood in terms of a non-local effect in which the heat flow from heat source to the cold environment generates power via a mechanism which we refer to as Coulomb heat drag. It relies on the fact that there is no relaxation in the quantum dot system, so electrons within it have a non-thermal energy distribution. More poetically, one can say that we find a spatial separation of the first-law of thermodynamics (heat to work conversion) from the second-law of thermodynamics (generation of entropy). We present circumstances in which this non-thermal system can generate more power than any conventional macroscopic thermocouple (with local thermalization), even when the latter works with Carnot efficiency.
description: Special issue of Physica E "Frontiers in Quantum Electronic Transport - In Memory of Markus B\"uttiker". 10 pages, 6 figures
Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer
Creators: name: Barnholtz-Sloan, Jill S.
name: Weissler, Mark C.
name: North, Kari E.
name: Hakenewerth, Anne M.
name: Rusyn, Ivan
name: Olshan, Andrew F.
name: Funkhouser, William K.
name: Millikan, Robert C.
name: Herring, Amy H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Heavy alcohol consumption increases risk of developing squamous cell carcinoma of the head and neck (SCCHN). Alcohol metabolism to cytotoxic and mutagenic intermediates acetaldehyde and reactive oxygen species is critical for alcohol-drinking-associated carcinogenesis. We hypothesized that polymorphisms in alcohol metabolism-related and antioxidant genes influence SCCHN survival.
title: Acute testicular pain: ultrasound findings in paediatric population
Creators: name: ben abdeladhim, yasmine
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system male
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Education
subject: Acute
subject: Infection
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aim of this study is to recognize the different diagnosis of acute scrotum and differentiate between diseases that require immediate surgical intervention and those that can be treated conservatively. The typical clinical history and ultrasound...
Personal Networks as Social Capital: a Research Strategy to Measure Contents and Forms of Social Support
Creators: name: Di Nicola, Paola
name: Stanzani, Sandro
name: Tronca, Luigi
Publisher: name: QuiEdit
Year: 2015
Subjects: personal network; social capital; social circles

description: The basic idea of social capital consists of the belief that individuals’ lives can be qualitatively improved by social relationships, or rather by the social resources that these relationships manage to mobilize. So, personal networks can provide a kind of capital for individuals. This essay examines the characteristics of personal networks that mobilize social resources in a sample of 307 individuals, representative of the population of Verona (Italy). By using some structural indicators of social capital, the authors describe the contents and the forms of different kinds of social circles (family, work colleagues, members in third sector organizations, friends, neighbours). This study rejects a hypothesis according to which stronger ties are better vehicles for symbolic and expressive resources, and confirms a hypothesis on the similarity of the forms of different social circles that provide individuals with social support.
description: Italian Sociological Review, Vol 1, No 1 (2011)
Risk factors for Kaposi's sarcoma among HIV-positive individuals in a case control study in Cameroon
Creators: name: Miley, Wendell
name: Iriondo-Perez, Jeniffer
name: Ryder, Robin
name: Woelk, Godfrey
name: Ndom, Paul
name: Stella, Jennifer
name: Abassora, Mahamat
name: Stolka, Kristen
name: Labo, Nazzarena
name: Hemingway-Foday, Jennifer
name: Whitby, Denise
name: Smith, Jennifer S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Individuals co-infected with Kaposi’s sarcoma herpesvirus (KSHV) and Human Immunodeficiency Virus (HIV) are at greatly increased risk of developing Kaposi’s sarcoma (KS). The objective of the current analysis is to identify risk cofactors, for KS among HIV-positive individuals.
title: MRI role in extraintestinal manifestation of Chron disease: protocols and findings.
Creators: name: Irmici, Giovanni
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: MR
subject: Imaging sequences
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To discuss the role of MRI in principal extraintestinal Crohn disease (CD) manifestations' and MRI protocols used in our...
Online Supplement for Adaptive Irrigation Management Significantly Reduces GHG Emissions and Increases Yields in Balinese Rice Terraces from Adaptive irrigation management by balinese farmers reduces GHG emissions and increases rice yields
Creators: name: Lansing, J. S.
name: Kremer, J. N.
name: Suryawan, I. B. G.
name: Sathiakumar, S.
name: Jacobs, G. S.
name: Chung, N. N.
name: Artha Wiguna, I. Wy A.
Publisher: name: The Royal Society
Year: 2023
Subjects: Environmental Science
Animal Behaviour

description: The potential for changes in water management regimes to reduce greenhouse gases (GHG) in rice paddies has recently become a major topic of research in Asia, with implications for top-down versus bottom-up management strategies. Flooded rice paddies are a major source of anthropogenic GHG emissions and are responsible for approximately 11% of global anthropogenic CH4 emissions. But rice is also the most important food crop for people in low- and lower-middle-income countries. While CH4 emissions can be reduced by lessening the time the plants are submerged, this can trigger increased emissions of nitrous oxide N2O, a more potent greenhouse gas. Mitigation options for CH4 and N2O are different, and minimizing one gas may increase the emission of the other. Accurate measurement of these gas emissions in rice paddies is difficult, and the results are controversial. We analysed these trade-offs using continuous high-precision measurements in a closed chamber in 2018–2020. Based on the results, we tested a bottom-up adaptive irrigation regime that improves nitrogen uptake by rice plants while reducing combined GHG emissions and nitrogen runoff from paddies to reefs in agricultural drainages. In 2023, we undertook a follow-up study in which farmers obtained higher rice yields with adaptive intermittent irrigation compared to uniformly flooded fields. These results use the polycentric, self-governing capacity of Balinese subaks for continuous adaptation.This article is part of the theme issue ‘Climate change adaptation needs a science of culture’.
Supplementary Text from A Bayesian approach to estimating hidden variables as well as missing and wrong molecular interactions in ordinary differential equation-based mathematical models.
Creators: name: Engelhardt, Benjamin
name: Kschischo, Maik
name: Fröhlich, Holger
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Supplementary text including additional figures, tables and methodological details.
Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance
Creators: name: Yang, Huijun
name: Cavenee, Webster K.
name: Zhang, Yinan
name: Gini, Beatrice
name: Baldwin, Albert S.
name: Dang, Julie
name: Dan, Hancai
name: Cloughesy, Timothy F.
name: Gera, Joseph F.
name: Vinters, Harry V.
name: Zhu, Shaojun
name: Dibble, Christian C.
name: Guo, Deliang
name: Rinkenbaugh, Amanda
name: Amzajerdi, Ali Nael
name: Yong, William H.
name: Manning, Brendan D.
name: de Jesus, Jason
name: Tanaka, Kazuhiro
name: Babic, Ivan
name: Nathanson, David
name: Mischel, Paul S.
name: Akhavan, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Although it is known that mTOR complex 2 (mTORC2) functions upstream of Akt, the role of this protein kinase complex in cancer is not well understood. Through an integrated analysis of cell lines, in vivo models and clinical samples, we demonstrate that mTORC2 is frequently activated in glioblastoma (GBM), the most common malignant primary brain tumor of adults. We show that the common activating epidermal growth factor receptor (EGFR) mutation (EGFRvIII) stimulates mTORC2 kinase activity, which is partially suppressed by PTEN. mTORC2 signaling promotes GBM growth and survival, and activates NF-κB. Importantly, this mTORC2-NF-κB pathway renders GBM cells and tumors resistant to chemotherapy in a manner independent of Akt. These results highlight the critical role of mTORC2 in GBM pathogenesis, including through activation of NF-κB downstream of mutant EGFR, leading to a previously unrecognized function in cancer chemotherapy resistance. These findings suggest that therapeutic strategies targeting mTORC2, alone or in combination with chemotherapy, will be effective in cancer.
Persistent Skyrmion Lattice of Noninteracting Electrons with Spin-Orbit Coupling
Creators: name: Fu, Jiyong
name: Penteado, Poliana H.
name: Hachiya, Marco O.
name: Loss, Daniel
name: Egues, J. Carlos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A persistent spin helix (PSH) is a robust helical spin-density pattern arising in disordered 2D electron gases with Rashba $α$ and Dresselhaus $β$ spin-orbit (SO) tuned couplings, i.e., $α=\pmβ$. Here we investigate the emergence of a Persistent Skyrmion Lattice (PSL) resulting from the coherent superposition of PSHs along orthogonal directions -- crossed PSHs -- in wells with two occupied subbands $ν=1,2$. For realistic GaAs wells we show that the Rashba $α_ν$ and Dresselhaus $β_ν$ couplings can be simultaneously tuned to equal strengths but opposite signs, e.g., $α_1= β_1$ and $α_2=-β_2$. In this regime and away from band anticrossings, our {\it non-interacting} electron gas sustains a topologically non-trivial skyrmion-lattice spin-density excitation, which inherits the robustness against spin-independent disorder and interactions from its underlying crossed PSHs. We find that the spin relaxation rate due to the interband SO coupling is comparable to that of the cubic Dresselhaus term as a mechanism of the PSL decay. Near anticrossings, the interband-induced spin mixing leads to unusual spin textures along the energy contours beyond those of the Rahsba-Dresselhaus bands. Our PSL opens up the unique possibility of observing topological phenomena, e.g., topological and skyrmion Hall effects, in ordinary GaAs wells with non-interacting electrons.
description: 5 pages, 2 figures; changed the presentation and added supplemental material (17 pages, 1 figure)
PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
Creators: name: Aura, Claudia
name: He, Lei
name: Cozar, Patricia
name: Rodón, Jordi
name: Anton, Pilar
name: Rodríguez, Olga
name: Rubio, Isabel T.
name: Pérez, José
name: Cortés, Javier
name: Guzmán, Marta
name: Grueso, Judit
name: Baselga, José
name: Ibrahim, Yasir H.
name: Torres-Lockhart, Kristine
name: Prat, Aleix
name: Ellisen, Leif W.
name: Calvo, Maria Teresa
name: Serra, Violeta
name: García-García, Celina
name: Díez, Orland
name: Scaltriti, Maurizio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: PARP inhibitors are active in tumors with defects in DNA homologous recombination (HR) due to BRCA1/2 mutations. The phosphoinositide 3-kinase (PI3K) signaling pathway preserves HR steady state. We hypothesized that in BRCA-proficient triple-negative breast cancer (TNBC), PI3K inhibition would result in HR impairment and subsequent sensitization to PARP inhibitors. We show in TNBC cells that PI3K inhibition leads to DNA damage, downregulation of BRCA1/2, gain in poly-ADP-ribosylation, and subsequent sensitization to PARP inhibition. In TNBC patient–derived primary tumor xenografts, dual PI3K and PARP inhibition with BKM120 and olaparib reduced the growth of tumors displaying BRCA1/2 downregulation following PI3K inhibition. PI3K-mediated BRCA downregulation was accompanied by extracellular signal–regulated kinase (ERK) phosphorylation. Overexpression of an active form of MEK1 resulted in ERK activation and downregulation of BRCA1, whereas the MEK inhibitor AZD6244 increased BRCA1/2 expression and reversed the effects of MEK1. We subsequently identified that the ETS1 transcription factor was involved in the ERK-dependent BRCA1/2 downregulation and that knockdown of ETS1 led to increased BRCA1/2 expression, limiting the sensitivity to combined BKM120 and olaparib in 3-dimensional culture.
title: On the Geometry of the Moduli Space of Certain Lattice Polarized K3 Surfaces and Their Picard-Fuchs Operators
Creators: name: Schultz, Michael T.
Publisher: name: Utah State University
Year: 2021

description: K3 surfaces have a long and rich study in mathematics, and more recently in physics via string theory. Often, K3 surfaces come in multiparameter families - the parameters describing these surfaces fit together to form their own geometric space, a so-called moduli space. In particular, the moduli spaces of K3 surfaces equipped with a lattice polarization can sometimes be constructed explicitly, which subsequently reveals important information about the original K3 surface.
In this work, we construct such families explicitly from certain rational elliptic surfaces via the so-called mixed-twist construction of Doran & Malmendier, which in turn produces the moduli space. After identifying the lattice polarization by computing Jacobian elliptic fibrations, we find a rich differential geometric content imparted to the moduli space - an integrable holomorphic conformal structure - via quadratic relations satisfied by the period integrals of the K3 surface. This geometry allows one to compute crucial data about the K3 surface family, the Picard-Fuchs operators, by applying a general programme on uniformizing differential equations discovered by Sasaki & Yoshida. In physics, this differential geometric data is known as a flat special geometry, and has implications for a type of supersymmetric quantum field theory associated with the K3 surface. Via the mixed-twist construction, this is related to Nf= 4 Seiberg-Witten curves from N = 2 SU(2) super Yang-Mills theory with various mass configurations.
We show as well how one can restrict the moduli, leading to subvarieties of the moduli space on which the lattice polarization extends. This can allow one to construct interesting families of Calabi-Yau manifolds, which are of crucial importance in string theory as well. Moreover, we study how other data that governs the complex structure of the elliptic fibres of certain generic fibrations determines global information about a Jacobian elliptic K3 surface in terms of string theoretic and index theoretic terms via holomorphic anomalies.
Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Creators: name: Mikse, Oliver R.
name: Reibel, Jacob B.
name: Tchaicha, Jeremy H.
name: Carretero, Julian
name: Janne, Pasi A.
name: Butaney, Mohit
name: Sholl, Lynette M.
name: Hammerman, Peter S.
name: Rodig, Scott J.
name: Fecci, Peter E.
name: Wong, Kwok Kin
name: Soucheray, Margaret
name: Wilkerson, Matthew D.
name: Koyama, Shohei
name: Akbay, Esra A.
name: Meyerson, Matthew
name: Beauchamp, Ellen M.
name: Pugh, Trevor J.
name: Shapiro, Geoffrey I.
name: Cherniack, Andrew D.
name: Cohoon, Travis J.
name: Altabef, Abigail
name: Neil Hayes, D.
name: Freeman, Gordon J.
name: Shimamura, Takeshi
name: Christensen, Camilla L.
name: Dranoff, Glenn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The success in lung cancer therapy with Programmed Death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between Epidermal Growth Factor Receptor (EGFR) pathway activation and a signature of immunosuppression manifested by upregulation of PD-1, PD-L1, cytotoxic T lymphocyte antigen-4 (CTLA-4), and multiple tumor-promoting inflammatory cytokines. We observed decreased cytotoxic T cells and increased markers of T cell exhaustion in mouse models of EGFR-driven lung cancer. PD-1 antibody blockade improved the survival of mice with EGFR-driven adenocarcinomas by enhancing effector T cell function and lowering the levels of tumor-promoting cytokines. Expression of mutant EGFR in bronchial epithelial cells induced PD-L1, and PD-L1 expression was reduced by EGFR inhibitors in non-small cell lung cancer cell lines with activated EGFR. These data suggest that oncogenic EGFR signaling remodels the tumor microenvironment to trigger immune escape, and mechanistically link treatment response to PD-1 inhibition.
A spectral theory for solvable Lie algebras of operators
Creators: name: Boasso, Enrico
name: Larotonda, Angel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 47A13, Secondary 17B30, 47D99

description: The main objective of this paper is to develop a notion of joint spectrum for complex solvable Lie algebras of operators acting on a Banach space, which generalizes the Taylor joint spectrum (T.J.S.) for several commuting operators.
description: 7 pages, original research article
Family values and domestic interiors. A material-culture experiment using multi-technique analysis
Creators: name: Secondulfo, Domenico
Publisher: name: QuiEdit
Year: 2015
Subjects: consumption; material culture; family values

description: The aim of this paper is to show the results of a field research that examines the integration between the use of a questionnaire and the use of photographs in the quantitative analysis, to analyze models of values reflected in the furniture arrangement with special attention to the methodology used, to verify the compatibility of Visual techniques with quantitative questionnaires, and that to reinforce the importance of sociological observation of material culture to describe and understand social life.
description: Italian Sociological Review, Vol 1, No 1 (2011)
Change and social forms
Creators: name: Viviani, Debora
Publisher: name: QuiEdit
Year: 2015
Subjects: social change; social forms; genetic structuralism

description: The social structure is constantly changing. While striving to study society, it is therefore clear that sociology has to identify, highlight and embrace the fundamental concepts, the conceptual categories that make it possible to become familiar with, understand, interpret and explain events. However, if the analysis of social transformations can reveal a common denominator that appears to be the characteristic interpretative key for each society, does it mean that there is a common underlying structure at the root of every change?

After the existence of a common principle (form) or a common denominator for every society and historical-social period has been established, we need to ask if this common denominator contributes towards the organisation of social phenomena (first perspective) or whether it is an interpretive category, an analytical grid that the subject applies in his knowledge of society (second perspective). Does the subject give form to society through specific interpretive categories (Panofsky), or is society generated and modified by a formal social structure (Goldmann)?
description: Italian Sociological Review, Vol 1, No 1 (2011)
Supplementary Text from A Bayesian approach to estimating hidden variables as well as missing and wrong molecular interactions in ordinary differential equation-based mathematical models
Creators: name: Engelhardt, Benjamin
name: Kschischo, Maik
name: Fröhlich, Holger
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Supplementary text including additional figures, tables and methodological details.
title: Primary and secondary CNS lymphoma: An educational exhibit
Creators: name: Kheng, Yuan Chun
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Education
subject: Lymphoma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: -To illustrate a wide spectrum of central nervous system (CNS) lymphoma and its subtypes.-To provide a comprehensive review of characteristic imaging features of primary and secondary CNS...
Supplementary material for "Real option valuation of a decremental regulation service provided by electricity storage".
Creators: name: Szabó, Dávid Zoltán
name: Martyr, Randall
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: This paper is a quantitative study of a reserve contract for real-time balancing of a power system. Under this contract, the owner of a storage device, such as a battery, helps smooth fluctuations in electricity demand and supply by using the device to increase electricity consumption. The battery owner must be able to provide immediate physical cover, and should therefore have sufficient storage available in the battery before entering the contract. Accordingly, the following problem can be formulated for the battery owner: determine the optimal time to enter the contract and, if necessary, the optimal time to discharge electricity before entering the contract. This problem is formulated as one of optimal stopping, and is solved explicitly in terms of the model parameters and instantaneous values of the power system imbalance. The optimal operational strategies thus obtained ensure that the battery owner has positive expected economic profit from the contract. Furthermore, they provide explicit conditions under which the optimal discharge time is consistent with the overall objective of power system balancing. This paper also carries out a preliminary investigation of the ‘lifetime value’ aggregated from an infinite sequence of these balancing reserve contracts. This lifetime value, which can be viewed as a single project valuation of the battery, is shown to be positive and bounded. Therefore, in the long run such reserve contracts can be beneficial to commercial operators of electricity storage, while reducing some of the financial and operational risks in power system balancing.