cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of Cytokine response to the RSV antigen delivered by dendritic cell-directed vaccination in congenic chicken lines
Creators: name: Mucksová, Jitka
name: Jiří Plachý
name: Ondřej Staněk
name: Jiří Hejnar
name: Jiří Kalina
name: Benešová, Barbora
name: Trefil, Pavel
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supplementary Materials and methods. Additional description of anti-chicken CD205 monoclonal antibody preparation, the construction, expression and purification of the recombinant SA-RSV fusion proteins and the description of amino acid sequence CD205 protein.
Additional file 2: of Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro
Creators: name: Doynova, Malina
name: Markworth, James
name: Cameron-Smith, David
name: Vickers, Mark
name: OâSullivan, Justin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods. (DOCX 53 kb)
Additional file 2: of Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro
Creators: name: Doynova, Malina
name: Markworth, James
name: Cameron-Smith, David
name: Vickers, Mark
name: OâSullivan, Justin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods. (DOCX 53 kb)
Neuroctenus granulatus Kormilev 1973
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Neuroctenus
Neuroctenus granulatus

description: Neuroctenus granulatus Kormilev, 1973
Neuroctenus granulatus Kormilev 1973b: 205; Kormilev & Froeschner 1987: 168. Holotype 3, Vietnam, Tonkin, Ha-Giang, 1913, Cap. Bonifacy coll. (MNHN).
Distribution: Vietnam (Ha Giang).
Notes: Ha-Giang = Ha Giang (Ha Giang Province).
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 57, DOI: 10.5281/zenodo.204787
Additional file 1: of Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery
Creators: name: H. Kirov
name: M. Schwarzer
name: S. Neugebauer
name: G. Faerber
name: M. Diab
name: T. Doenst
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Table S1. List of metabolites used in the analysis and corresponding abbreviations. (DOCX 27 kb)
Alternative outcome variables and measures in tourism research
Creators: name: Uysal, Muzzo
Publisher: name: ZPID (Leibniz Institute for Psychology)
Year: 2020
Subjects: subject: 150

description: Outline: I . Setting the stage and some general trends. II. Examples of 'team' studies with alternative outcome variables. III. Emerging themes and research – business implication.
description: Keynote at the virtual conference Consumer Behavior in Tourism Symposium (CBTS) 2020
Additional file 2: of Multimorbidity, clinical decision making and health care delivery in New Zealand Primary care: a qualitative study
Creators: name: Stokes, Tim
name: Tumilty, Emma
name: Doolan-Noble, Fiona
name: Gauld, Robin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: COREQ-32 reporting checklist. An assessment of the study reporting against the domains of the COREQ-32 reporting checklist for interviews and focus groups. (PDF 208Â kb)
Plecturocebus cupreus
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Pitheciidae
Plecturocebus
Plecturocebus cupreus

description: Callithrix cuprea Spix, 1823
Simiarum et Vespertilionum Brasiliensium species novae, p. 23
Current valid name: Plecturocebus cupreus (Spix, 1823)
Paralectotype: ZMB 264, male, adult, skull [not located], skin; Brazil, received from Museum München, donated by Spix.
Comment: Hill (1960: 122) designated a female, adult, mounted skin, skull inside (ZSM 10) in München as the lectotype. Three further paralectotypes are in München (ZSM 24, ZSM 89 a, and ZSM 89 b), and one further paralectotype in Leiden (Paralectotype, RMNH.MAM.39086).
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on page 159, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
title: Production of the sheep pox virus structural protein SPPV117 in tobacco chloroplasts
Creators: name: Stanbekova, Gulshan
name: Beisenov, Daniyar
name: Nizkorodova, Anna
name: Iskakov, Bulat
name: Warzecha, Heribert
Publisher: name: Springer Science
Year: 2024

description: Objective: A chloroplast transgenic approach was assessed in order to produce a structural protein SPPV117 of sheep pox virus in Nicotiana tabacum for the future development of a plant-based subunit vaccine against sheep pox.

Results: Two DNA constructs containing SPPV117 coding sequence under the control of chloroplast promoter and terminator of psbA gene or rrn promoter and rbcL terminator were designed and inserted into the chloroplast genome by a biolistic method. The transgenic plants were selected via PCR analysis. Northern and Western blot analysis showed expression of the transgene at transcriptional and translational levels, respectively. The recombinant protein accumulated to about 0.3% and 0.9% of total soluble protein in leaves when expressed from psbA and rrn promoter, respectively. Plant-produced SPPV117 protein was purified using metal affinity chromatography and the protein yield was 19.67 ± 1.25 µg g⁻¹ (FW). The serum of a sheep infected with the virus recognised the chloroplast-produced protein indicating that the protein retains its antigenic properties.

Conclusions: These results demonstrate that chloroplasts are a suitable system for the production of a candidate subunit vaccine against sheep pox.
Neuroctenus
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Neuroctenus

description: Neuroctenus par Bergroth, 1887
Neuroctenus par Bergroth 1887: 180; Kormilev 1971: 70; Kormilev & Froeschner 1987: 172; Heiss 2001: 31. Distribution: Vietnam, Thailand, Laos, Indonesia, Philippines, New Guinea (NW & NE), New Britain, Guadalcanal.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 57, DOI: 10.5281/zenodo.204787
On the joint distribution of the area and the number of peaks for Bernoulli excursions
Creators: name: Kargin, Vladislav
Publisher: name: arXiv
Year: 2024
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Let $P_n$ be a random Bernoulli excursion of length $2n$. We show that the area under $P_n$ and the number of peaks of $P_n$ are asymptotically independent. We also show that these statistics have the correlation coefficient asymptotic to $c /\sqrt{n}$ for large $n$, where $c < 0$, and explicitly compute the coefficient $c$.
description: 21 pages, 1 figure
Building Resources and Tools for an Open Science Community at NASA's Jet Propulsion Laboratory
Creators: name: Knosp, Brian
name: Coward, Caroline
name: Crichton, Daniel
name: Limonadi, Daniel
name: Styczinski, Marshall
name: Yuen, Karen
Publisher: name: Zenodo
Year: 2024
Subjects: open science
NASA
JPL

description: With the release of NASA’s Science Information Policy (SPD-41a), NASA’s Jet Propulsion Laboratory (JPL) has effectively laid the groundwork to move the organization from individual, isolated, and siloed activities toward a coordinated open science community.

As with any large organization, effecting change can be a slow and challenging process, and it is critical to make any new or updated policies and tools easy to adopt.  It is also essential to communicate transparently and effectively to assuage any fears.  This was our goal at JPL.  Once SPD-41a was released, a grass-roots group organized and took action to coordinate open science responses and efforts.  The result is that many open science tools and resources are now available to the JPL community, such as:

The JPL Open Repository (JOR)

Proposal templates for Open Science and Data Management Plans (OSDPMs)

Open Science 101 trainings from the NASA Transform to Open Science (TOPS) program’s JPL Team

A wiki area to share knowledge

An Open Science Seminar series

An Open Science Slack channel

Most importantly, requirements and expectations for open science were communicated at large institution-wide events, such as an SPD-41a Town Hall meeting held in March 2023.

In this presentation, we will summarize the successes and challenges that we faced in helping to build the JPL open science community.  We will also highlight different tools that the organization has developed to help the research community develop data, software, and results in the open.  We can celebrate these successes as we continue to look towards the exciting, open future.
MOESM2 of Cytokine response to the RSV antigen delivered by dendritic cell-directed vaccination in congenic chicken lines
Creators: name: Mucksová, Jitka
name: Jiří Plachý
name: Ondřej Staněk
name: Jiří Hejnar
name: Jiří Kalina
name: Benešová, Barbora
name: Trefil, Pavel
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2. List of primers used in the study. Sequences of primers used in anti-CD205 antigen cloning.
Cheracebus torquatus
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Pitheciidae
Cheracebus
Cheracebus torquatus

description: Cebus torquatus Hoffmannsegg, 1807
Magazin der Naturforschenden Gesellschaft zu Berlin 1807, p. 86
Current valid name: Cheracebus torquatus (Hoffmannsegg, 1807)
Holotype: ZMB 265, male, skull, skin; Para, Brazil; collected by Sieber, undated.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on page 159, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
Additional file 3: Figure S1. of Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro
Creators: name: Doynova, Malina
name: Markworth, James
name: Cameron-Smith, David
name: Vickers, Mark
name: OâSullivan, Justin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Determination of the total nuclei and percent of differentiation in the course of cell culture. Figure S2. Transcript levels, measured as FPKM values, were highly correlated between biological replicates. Figure S3. Cytosolic DNA-sensing pathway was enriched (pâ  =â  0.049) within the gene set containing the top 10% of significantly upregulated genes for AraC-treated myotubes vs myotubes comparison. Figure S4. QC report generated after processing of the myoblasts replicate 1 Hi-C library. Figure S5. QC report generated after processing of the myoblasts replicate 2 Hi-C library. Figure S6. QC report generated after processing of the myotubes (day 3) replicate 1 Hi-C library. Figure S7. QC report generated after processing of the myotubes (day 3) replicate 2 Hi-C library. Figure S8. QC report generated after processing of the myotubes (day 7 + AraC) replicate 1 Hi-C library. Figure S9. QC report generated after processing of the myotubes (day 7 + AraC) replicate 2 Hi-C library. Figure S10. Patches of replication-dependent histone variants spatially clustered within the HIST1 locus. Figure S11. Distributions of shared and unique interactions and TADs across the three conditions. Figure S12. Two consensus TADs visualized on the UCSC genome browser spanning developmentally regulated arrays of muscle genes and their corresponding histone mark signals on chr1. (DOCX 2373 kb)
Plecturocebus moloch
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Pitheciidae
Plecturocebus
Plecturocebus moloch

description: Cebus moloch Hoffmannsegg, 1807
Magazin der Naturforschenden Gesellschaft zu Berlin 1807, p. 97
Valid name: Plecturocebus moloch (Hoffmannsegg, 1807)
Syntypes: ZMB 262, male, skull, skin; ZMB 263, female, skull, skin; Para, Brazil; collected by Sieber, undated.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on page 159, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
Neuroctenus subserrulatus Vasarhelyi 1988
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Neuroctenus
Neuroctenus subserrulatus

description: Neuroctenus subserrulatus Vásárhelyi, 1988
Neuroctenus subserrulatus Vásárhelyi 1988: 27. Holotype 3, Vietnam, Vinh Phú, Tam Dao, 200m, 12.X.1986, Vásárhelyi coll. (HNHM).
Distribution: Vietnam (Vinh Phuc, Tam Dao).
Notes: Vinh Phú (Vinh Phu Province ago) = Vinh Phuc.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 57, DOI: 10.5281/zenodo.204787
MOESM4 of Preparation and characterization of novel double-decker rare-earth phthalocyanines substituted with 5-bromo-2-thienyl groups
Creators: name: Jiří Černý
name: Dokládalová, Lenka
name: Horáková, Petra
name: Lyčka, Antonín
name: Tomáš Mikysek
name: Bureš, Filip
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Additional file 4. FT-IR spectra of 2–4 in KBr pellets.
Chiropotes satanas
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Pitheciidae
Chiropotes
Chiropotes satanas

description: Cebus satanas Hoffmannsegg, 1807
Magazin der Naturforschenden Gesellschaft zu Berlin 1807, p. 93
Current valid name: Chiropotes satanas (Hoffmannsegg, 1807)
Syntypes: ZMB 248, female, skull, skin; ZMB 249, male, skull, skin; both specimens from Para, Brazil, collected by Sieber, undated.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on pages 159-160, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
Self-Driven by Vice
Creators: name: Tang, Xichen
Publisher: name: Zenodo
Year: 2024

description: This paper explores the relationship between vice and self-driven motivation through the lenses of existentialist and absurdist philosophy, while incorporating perspectives from humanistic psychology. It challenges traditional views of vice as a moral flaw or dysfunction, proposing instead that vices—ranging from basic impulses to more complex desires—serve as authentic expressions of human existence in an absurd world. Drawing on phenomenological analysis, the study highlights how vices can function as catalysts for personal growth, self-realization, and motivation. The paper uses historical case studies and philosophical reasoning to show how struggles with vice can spur societal transformation, revealing a paradoxical connection between moral elevation and existential authenticity. Ultimately, the research suggests that vice is not merely moral failure, but an inherent part of the human quest for meaning and self-expression in the face of life's inherent absurdity.
Thaumastaneis montandoni Kirkaldy and Edwards 1902
Creators: name: Dellapé, Pablo Matías
name: Melo, María Cecilia
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Largidae
Thaumastaneis
Thaumastaneis montandoni

description: Thaumastaneis montandoni Kirkaldy and Edwards 1902
(Figs 7–17)
Until now nothing has been reported about the biology of this species. Van Doesburg (1966) only mentioned that “the strongly ant-like appearance suggests some relation with ants”. The authors collected in Ituzaingó, Corrientes prov. (Argentina) several adults of T. montandoni (Fig. 17) (deposited in MLP).
Scanning electron microscopy shows some structural modifications that enhance mimicry: silvery reflective hairs on lateral regions of the hemelytra (Fig. 12), pitted areas on the neck (fig. 13), and thoracic spines (Fig. 14).
Van Doesburg (1966) and Schaefer (2000) described the antennae, tibiae, and tarsi of T. montandoni as light brown or yellowish brown. These structures are reddish in the field and in recently collected specimens, although after a short time we observed they had turned to light brown.
We also note that although Schaefer (2000) described in Thaumastaneis montandoni fifth instar as having only two dorsal abdominal scent gland openings (between terga III–IV and IV–V), we find three in the adults of both species of Thaumastaneis, the third lying between terga V–VI. Moreover, the first gland appears to be functional (Figs. 15–16).
Associated with T. montandoni we collected adult workers of a species of the ant genus Camponotus (Fig. 18) (Hymenoptera: Formicidae), as well as an undescribed species of myrmecomorphic cricket (Fig. 19) (Orthoptera: Trigonidiidae). The general color of these species is black, with particular regions of the legs reddish: coxae, trochanters, and femora in the ants; femora and tarsi in the cricket. This color pattern and the antlike appearance of both the heteropteran and the orthopteran suggests the presence of a mimetic complex.
We also record Thaumastaneis montandoni for the first time from Paraguay, Dept. San Pedro, Carumbé; the specimens examined (2 males, 3 females) belong to the Instituto Miguel Lillo Entomological Collection.
description: Published as part of Dellapé, Pablo Matías & Melo, María Cecilia, 2007, Thaumastaneis nigricans, a new species of a remarkable ant-mimetic Larginae (Hemiptera: Largidae) and the discovery of an ant-mimetic complex, pp. 21-26 in Zootaxa 1475 on pages 24-26, DOI: 10.5281/zenodo.273774
Cercocebus agilis Milne-Edwards 1886
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Cercopithecidae
Cercocebus
Cercocebus agilis

description: Cercocebus fumosus Matschie, 1914
Sitzungsberichte der Gesellschaft Naturforschender Freunde zu Berlin, p. 340
Current valid name: Cercocebus agilis Milne-Edwards, 1886
Holotype: ZMB 32789/32790 (= A 11a, 08, 378), female, adult, skull, skin; Wälder NW Beni at Semliki River, Democratic Republic of the Congo; collected by Herzog Adolf Friedrich zu Mecklenburg, March 1908.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on page 160, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
Additional file 1: Table S1. of Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori
Creators: name: Ra, Seung
name: Sze, Marc
name: Lee, Eun
name: Tam, Sheena
name: Yeni Oh
name: Fishbane, Nick
name: Criner, Gerard
name: Prescott Woodruff
name: Lazarus, Stephen
name: Albert, Richard
name: Connett, John
name: Meilan Han
name: Martinez, Fernando
name: Aaron, Shawn
name: Reed, Robert
name: S. Man
name: Sin, Don
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Patient characteristics according to Helicobacter pylori status and treatment. Table S2. Effect of Helicobacter pylori status at enrollment and treatment on the rates of exacerbation per person-year. Table S3. Comparison of the proportion of subjects that showed significant reduction in HP antibody level at 12Â months in 113 COPD patients. Table S4. Effect of treatment on changes in CRP level from baseline to 3Â months according to HP status. (DOCX 36Â kb)
Neuroctenus taiwanicus Kormilev 1955
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Neuroctenus
Neuroctenus taiwanicus

description: Neuroctenus taiwanicus Kormilev, 1955
Neuroctenus taiwanicus Kormilev 1955b: 39; Kormilev 1973a: 75; Vásárhelyi 1976: 411; Kormilev & Froeschner 1987: 175; Heiss 2001: 32. Holotype 1 Ƥ, Vietnam, Cuo Phuong, prov. Ninh Binh; 4.VI.1966, R. Bieglawski & S. Pisarski coll. (ZMPA).
Distribution: Vietnam (Ninh Binh, Cuc Phuong), China.
Notes: Cuo Phuong = Cuc Phuong.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on pages 57-58, DOI: 10.5281/zenodo.204787
Central immunological position of the human histo (blood) group O(H).
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Prokaryotic
"blood group A/B-like" antigenic structures apparently induce
basically cross-reactive anti-A/B immunoglobulins, which due to clonal
selection neither arise in blood group A nor in B individuals but occur
exclusively in blood group O. While bacterial endotoxins non-specifically
stimulate the formation of all immunoglobulins, most likely involving the
anti-A/B isoagglutinins, a definite, adaptive immunological induction of these
agglutinins appears to be restricted to blood group O(H) individuals. In the
non-O blood groups, anti-A/B reactivity is exerted by a primarily blood
group-independent, polyreactive and thymus-independent non-immune IgM molecule
that has undergone the phenotype-specific, glycosidic accommodation of plasma
proteins, which reduces or excludes anti-self reactivity, however, necessarily
involves impairment of immunity. While blood group A phenotype development thus
is associated with impaired formation of adaptive and innate immunoglobulins,
it promotes susceptibility to malaria infection via its intrinsic enzyme
functions, initiating a self-destructive glycosidic, phenotypic accommodation
of a "wrong eukaryote". Indeed, blood group A phenotype-specific
GalNAc transferase activities, expressed by both cell surfaces and plasma
proteins, and serine/threonine kinases from Plasmodium
falciparum, which via the life cycle of this parasite are getting into the red blood cell (RBC), might provide the metabolic condition
for adhesion protein and RBC rosette formation, assumingly based on heterologous O-glycosylation,
breaking a species barrier and completing the
"serine repeat antigen". Thus, the lack of blood group A phenotype-specific GalNAc  glycosylation(s) appears to be the explanation for the obvious protection of the human blood group O(H) from severe
malaria infection, and suggests a new molecular definition of the immunological, therapeutic
target. In
fact, the human histo (blood) group O finally represents the worldwide most
common blood type, protected by a superior, complex immunity, which in the
non-O blood groups is reduced through phenotypic, identical glycosylation of cell surfaces and plasma
proteins.
Odontonotus annulipes Hsiao 1964
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Odontonotus
Odontonotus annulipes

description: Odontonotus annulipes Hsiao, 1964
Odontonotus annulipes Hsiao1964: 592 (603); Kormilev 1971:134; Kormilev & Froeschner 1987: 181; Heiss 2001: 32.
Distribution: Vietnam, China.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 58, DOI: 10.5281/zenodo.204787
MOESM2 of Cytokine response to the RSV antigen delivered by dendritic cell-directed vaccination in congenic chicken lines
Creators: name: Mucksová, Jitka
name: Jiří Plachý
name: Ondřej Staněk
name: Jiří Hejnar
name: Jiří Kalina
name: Benešová, Barbora
name: Trefil, Pavel
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2. List of primers used in the study. Sequences of primers used in anti-CD205 antigen cloning.
Additional file 2: of Effectiveness of a novel mobile health education intervention (Peek) on spectacle wear among children in India: study protocol for a randomized controlled trial
Creators: name: Morjaria, Priya
name: Bastawrous, Andrew
name: Gudlavalleti Murthy
name: Evans, Jennifer
name: Gilbert, Clare
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: SPIRIT checklist. (PDF 36 kb)
Additional file 2: of Validation of the Dutch version of the Swallowing Quality-of-Life Questionnaire (DSWAL-QoL) and the adjusted DSWAL-QoL (aDSWAL-QoL) using item analysis with the Rasch model: a pilot study
Creators: name: Simpelaere, Ingeborg
name: Nuffelen, Gwen Van
name: Bodt, Marc De
name: Vanderwegen, Jan
name: Hansen, Tina
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Representation of the 5-point response categories for the different subscales of the aDSWAL-QoL. These pictures demonstrate how the 5-point response categories for the different subscales are presented in the aDSWAL-QoL with respect to the real size. Note that the translation of the response format into English can slightly deviate from the formulation in the Flemish language. (DOCX 149Â kb)
Central immunological position of the human histo (blood) group O(H).
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Prokaryotic
"blood group A/B-like" antigenic structures apparently induce
basically cross-reactive anti-A/B immunoglobulins, which due to clonal
selection neither arise in blood group A nor in B individuals but occur
exclusively in blood group O. While bacterial endotoxins non-specifically
stimulate the formation of all immunoglobulins, most likely involving the
anti-A/B isoagglutinins, a definite, adaptive immunological induction of these
agglutinins appears to be restricted to blood group O(H) individuals. In the
non-O blood groups, anti-A/B reactivity is exerted by a primarily blood
group-independent, polyreactive and thymus-independent non-immune IgM molecule
that has undergone the phenotype-specific, glycosidic accommodation of plasma
proteins, which reduces or excludes anti-self reactivity, however, necessarily
involves impairment of immunity. While blood group A phenotype development thus
is associated with impaired formation of adaptive and innate immunoglobulins,
it promotes susceptibility to malaria infection via its intrinsic enzyme
functions, initiating a self-destructive glycosidic, phenotypic accommodation
of a "wrong eukaryote". In fact, blood group A phenotype-specific
GalNAc transferase activities, expressed by both cell surfaces and plasma
proteins, and serine/threonine kinases, which are imported from Plasmodium
falciparum into the red cell membrane, might provide the metabolic condition
for adhesion protein and rosette formation, assumingly based on heterologous O-glycosylation,
breaking a species barrier and completing the
"serine repeat antigen". Thus,
it appears to be the lack of blood group A phenotype-specific GalNAc  glycosylation(s), which explains the obvious protection of the human blood group O(H) from severe
malaria infection, and suggests a new molecular definition of the therapeutic
target. In
fact, the human histo (blood) group O finally represents the worldwide most
common blood type, protected by a superior, complex immunity, which in the
non-O blood groups is impaired through phenotype diversity.
Odontonotus maai Kormilev 1955
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Odontonotus
Odontonotus maai

description: Odontonotus maai Kormilev, 1955
Odontonotus maai Kormilev 1955a: 179; Kormilev 1971:134; Kormilev & Froeschner 1987: 181; Heiss 2001: 32. Distribution: Vietnam, China.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 58, DOI: 10.5281/zenodo.204787
Cercocebus galeritus Peters 1879
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Cercopithecidae
Cercocebus
Cercocebus galeritus

description: Cercocebus galeritus Peters, 1879
Monatsberichte der Königlich Preussischen Akademie der Wissenschaften zu Berlin, p. 830
Current valid name: Cercocebus galeritus Peters, 1879
Holotype: ZMB 5546, male, adult, skull, skin (= A11a,08,378, skin not located); Peters: “Das einzige Exemplar, ein ausgewachsenes Männchen, wurde in Mitole, an der Mündung des Osi und Tana-Flusses, am 16 November erlegt;“ [The only specimen, an adult male, was shot in Mitole [at the Tana River, Kenya, see fig. 1], at the estuary of the Osi and Tana Rivers] on November 16th] collected by Fischer, 16 November 1878.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on pages 160-161, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
Additional file 2: of Validation of the Dutch version of the Swallowing Quality-of-Life Questionnaire (DSWAL-QoL) and the adjusted DSWAL-QoL (aDSWAL-QoL) using item analysis with the Rasch model: a pilot study
Creators: name: Simpelaere, Ingeborg
name: Nuffelen, Gwen Van
name: Bodt, Marc De
name: Vanderwegen, Jan
name: Hansen, Tina
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Representation of the 5-point response categories for the different subscales of the aDSWAL-QoL. These pictures demonstrate how the 5-point response categories for the different subscales are presented in the aDSWAL-QoL with respect to the real size. Note that the translation of the response format into English can slightly deviate from the formulation in the Flemish language. (DOCX 149Â kb)
Burhanudin Mukhamad Noor_C.131.21.0093_Evaluasi Infrastruktur Tanggul di Jakarta Kritik, Opini, dan Implikasi Keberlanjutan.pdf
Creators: name: MUKHAMAD NOOR, BURHANUDIN
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400501
subject: Architectural engineering

description: The construction of embankments in Jakarta is one of the strategic steps to overcome chronic flooding problems due to high rainfall, land subsidence and rising sea levels. Despite its importance, this infrastructure faces various criticisms that include planning that is less than holistic, implementation that is prone to corruption, minimal community participation, and significant environmental impacts. This research uses qualitative methods through literature study and document analysis to evaluate the planning, implementation and impact of embankment construction. This article proposes a sustainability-based approach and increased community participation to ensure the effectiveness of embankment infrastructure projects in Jakarta. The conclusion shows that the success of the embankment is highly dependent on transparency, accountability and active community involvement in all stages of development.
Usingerida carinata Hsiao 1964
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Usingerida
Usingerida carinata

description: Usingerida carinata Hsiao, 1964
Usingerida carinata Hsiao 1964: 595 (604); Kormilev 1971:132; Kormilev & Froeschner 1987: 194; Heiss 2001: 33.
Distribution: Vietnam, China.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 58, DOI: 10.5281/zenodo.204787
title: Die Arbeit der Kartenabteilung der Staatsbibliothek zu Berlin
Creators: name: Crom, Wolfgang
Publisher: name: Fachinformationsdienst für Kartographie und Geobasisdaten
Year: 2009
Subjects: subject: Kartensammlung
subject: Bibliothek
subject: Staatsbibliothek zu Berlin. Kartenabteilung
subject: map department
subject: mapduratorship
subject: 520

description: Vermessung Brandenburg, vol. 14, no. 1, p. 62
MOESM1 of Effects of community-level bed net coverage on malaria morbidity in Lilongwe, Malawi
Creators: name: Escamilla, Veronica
name: Alker, Alisa
name: Dandalo, Leonard
name: Juliano, Jonathan
name: Miller, William
name: Kamthuza, Portia
name: Tapiwa Tembo
name: Tegha, Gerald
name: Martinson, Francis
name: Emch, Michael
name: Hoffman, Irving
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Mixed effects logistic regression results for children under 5Â years stratified by bed net use.
Callimenellini Gorochov 1990
Creators: name: Connors, Matthew G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae

description: Callimenellini Gorochov, 1990
Available
Type genus Callimenellus Walker, 1871
Stem Callimenell-
Currently considered valid
Accepted name: Tribe Callimenellini
Parent taxon: Supertribe Pseudophylliti
description: Published as part of Connors, Matthew G., 2024, A nomenclatural review of family-group names in the Tettigoniidae (Orthoptera: Ensifera), pp. 1-51 in Zootaxa 5468 (1) on page 31, DOI: 10.11646/zootaxa.5468.1.1, http://zenodo.org/record/11613492
Usingerida topali Vasarhelyi 1976
Creators: name: Pham, Minhlan
name: Bai, Xiaoshuan
name: Heiss, Ernst
name: Cai, Wanzhi
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Aradidae
Usingerida
Usingerida topali

description: Usingerida topali Vásárhelyi, 1976
Usingerida topali Vásárhelyi 1976:411; Kormilev & Froeschner 1987: 195. Holotype Ƥ, Vietnam, Cuc phuong Ninh binh, 3–10.V.1966. (HNHM).
Distribution: Vietnam (Ninh Binh, Cuc Phuong; Kya-Pao; Bac shon O).
Notes: Cuc-phuong = Cuc Phuong; Kya-Pao = Hang Kia Commune and Pa Co Commune of Mai Chau District, Hoa Binh Province.
description: Published as part of Pham, Minhlan, Bai, Xiaoshuan, Heiss, Ernst & Cai, Wanzhi, 2011, An annotated check list of flat bugs (Hemiptera: Aradidae) from Vietnam, pp. 51-60 in Zootaxa 2967 on page 58, DOI: 10.5281/zenodo.204787
Eurydema qinlingensis Zheng 1982, comb. nov.
Creators: name: Zhao, Wanqing
name: Zhao, Qing
name: Li, Min
name: Wei, Jiufeng
name: Zhang, Xianhong
name: Zhang, Hufang
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Eurydema
Eurydema qinlingensis

description: Eurydema qinlingensis (Zheng, 1982) comb. nov.
Bagrada qinlingensis Zheng, 1982: 195.
Diagnosis. Body shape and color pattern similar to those of Bagrada, but the Whole black tibia significantly different (Fig. 6). Male genitalia also different; lateral sides of the pygophore apeX Wide ear-shaped (Figs. 7 A and B), paramere With a Wide base, tapered, apeX blunted (Fig. 7 C), vesica shorter than median plates, and median plates concave (Figs. 7 D and E).
Description. Body oblong and short, shining and sparse punctured, With black strips.
Head. Triangular and black, declined, thickly and roughly punctate. VerteX slightly conveX, sparse punctured. Mandibular plates slightly longer than clypeus and convergent anteriorly. Lateral mandibular plates With a smooth and narroW edge. Ocelli red, situated distinctly posteriad to the level of posterior margin of eyes, relatively far from eyes; eyes broWn. Head beneath black. Antenna black, segment V longest. Rostrum black, apeX surpassing the posterior margins of mesocoXae.
Thorax. Pronotum coarsely and unevenly punctate, tWo large black spots arranged equidistantly, occupied the most area. Anterior margin concave, With inconspicuous collar. Anterolateral margin smooth, Without ridge edge.
Lateral angle rounded, Weakly produced, seldom surpassing the base of Wing. Scutellum bell-shaped, black eXcept the apical half With a V-shaped red stripe; apeX of scutellum bluntly rounded. Hemelytron: corium black, eXcept the bases of outer margins narroWly reddish With same color punctures; apical angle not sharp; membranes ochraceous With each apeX surpassing beyond the abdomen. Legs black, apical half of tibia and tarsus With golden long hair.
Abdomen. Oval, black, eXcept conneXiva. Sternum VII reddish With concolorous punctures. Stigmata also black.
Male genitalia. Pygophore black, strongly sclerotized With a pair of posterolateral ear-shaped angles, situated much higher than notch in ventroposterior rim, apeX slightly crooked; dorsoposterior rim sinuated, With a pair subtriangular parandria; ventroposterior rim sinuated (Figs. 8 A and B). Paramere shaped duck-head, apeX narroW and blunt, base Wide and broad (Fig. 8 C). Aedeagus simple With one pair of basolateral conjunctival lobes, apices not bifurcate and a little sclerotized; apical conjunctival lobe developed, apeX sclerotized and slightly bifurcate. Vesica stretched out from the venter of median penial plates, shorter than median plates (Figs. 8 D and E).
Distribution. China: ShaanXi Province.
description: Published as part of Zhao, Wanqing, Zhao, Qing, Li, Min, Wei, Jiufeng, Zhang, Xianhong & Zhang, Hufang, 2017, DNA Barcoding of Chinese species of the genus Eurydema Laporte, 1833 (Hemiptera: Pentatomidae), pp. 151-175 in Zootaxa 4286 (2) on pages 155-157, DOI: 10.11646/zootaxa.4286.2.1, http://zenodo.org/record/828355
Beiericolyina Jin 1992
Creators: name: Connors, Matthew G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae

description: Beiericolyina Jin, 1992
Available
Type genus Beiericolya Kaltenbach, 1968
Stem Beiericoly-
Currently considered valid
Accepted name: Subtribe Beiericolyina
Parent taxon: Tribe Phisidini
description: Published as part of Connors, Matthew G., 2024, A nomenclatural review of family-group names in the Tettigoniidae (Orthoptera: Ensifera), pp. 1-51 in Zootaxa 5468 (1) on page 31, DOI: 10.11646/zootaxa.5468.1.1, http://zenodo.org/record/11613492
Cercopithecus ascanius subsp. schmidti Matschie 1892
Creators: name: Turni, Hendrik
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Cercopithecidae
Cercopithecus
Cercopithecus ascanius
Cercopithecus ascanius schmidti matschie, 1892

description: Cercopithecus Schmidti [sic] Matschie, 1892
Zoologischer Anzeiger 390, p. 161
Current valid name: Cercopithecus ascanius schmidti Matschie, 1892
Holotype: ZMB 33080/33180 (=A 5564) male, skull, mounted skin; between Mengo and Monjoni [?], Kampala, Murchison-Bay, Uganda; collected by Stuhlmann, January 1891.
Paratype: ZMB 33182/33183 (= A 5569), female, skull, skin; between Mengo and Monjoni [?], Kampala, Murchison-Bay, Uganda; collected by Stuhlmann, January 1891.
description: Published as part of Turni, Hendrik, 2024, Type specimens of Primates (Mammalia) in the collections of the Museum für Naturkunde Berlin, pp. 151-194 in Zootaxa 5543 (2) on page 161, DOI: 10.11646/zootaxa.5543.2.1, http://zenodo.org/record/14385859
MOESM1 of Effects of community-level bed net coverage on malaria morbidity in Lilongwe, Malawi
Creators: name: Escamilla, Veronica
name: Alker, Alisa
name: Dandalo, Leonard
name: Juliano, Jonathan
name: Miller, William
name: Kamthuza, Portia
name: Tapiwa Tembo
name: Tegha, Gerald
name: Martinson, Francis
name: Emch, Michael
name: Hoffman, Irving
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Mixed effects logistic regression results for children under 5Â years stratified by bed net use.
Austrosaginae Rentz 1993
Creators: name: Connors, Matthew G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae

description: Austrosaginae Rentz, 1993
Available
Type genus Austrosaga Rentz, 1993
Stem Austrosag-
Currently considered valid
Accepted name: Subfamily Austrosaginae
Parent taxon: Family Tettigoniidae
description: Published as part of Connors, Matthew G., 2024, A nomenclatural review of family-group names in the Tettigoniidae (Orthoptera: Ensifera), pp. 1-51 in Zootaxa 5468 (1) on pages 31-32, DOI: 10.11646/zootaxa.5468.1.1, http://zenodo.org/record/11613492
Orbital maneuvers for a space probe around Titania
Creators: name: Xavier, Jadilene
name: Bertachini, Antônio
name: Winter, Silvia Giuliatti
name: Amarante, Andre
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: For most space missions, it is interesting that the probe remains for a considerable time around the mission target. The longer the lifetime of a mission, the greater the chances of collecting information about the orbited body. In this work, we present orbital maneuvers that aim to show how to avoid a collision of a space probe with the surface of Titania. Through an expansion of the gravitational potential to the second order, the asymmetry of the gravitational field due to the coefficient $C_{22}$ of Titania, the zonal coefficient $J_2$, and the gravitational perturbation of Uranus are considered. Two models of coplanar bi-impulse maneuvers are presented. The first maneuver consists of transferring an initial elliptical orbit to a final circular orbit, and the second has the objective of transferring an initial elliptical orbit to a final orbit that is also elliptical. The lag in the inclination and semi-major axis of the orbits is investigated before performing the maneuvers. To point out the best scenarios for carrying out the maneuvers, a study is presented for different points of an orbit where transfers could be made. In addition, a maneuver strategy is presented to correct the variation of the periapsis argument. The results show that maneuvers performed a few days after integration are more economical than maneuvers performed later, a few days before the collision. The economy of the maneuvers is also demonstrated through an analysis of the ratio of the increase in speed to the lifetime.
description: Published on Eur. Phys. J. Spec. Top
Central immunological position of the human histo (blood) group O(H).
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Prokaryotic
"blood group A/B-like" antigenic structures apparently induce
basically cross-reactive anti-A/B immunoglobulins, which due to clonal
selection neither arise in blood group A nor in B individuals but occur
exclusively in blood group O. While bacterial endotoxins non-specifically
stimulate the formation of all immunoglobulins, most likely involving the
anti-A/B isoagglutinins, a definite, adaptive immunological induction of these
agglutinins appears to be restricted to blood group O(H) individuals. In the
non-O blood groups, anti-A/B reactivity is exerted by a primarily blood
group-independent, polyreactive and thymus-independent non-immune IgM molecule
that has undergone the phenotype-specific, glycosidic accommodation of plasma
proteins, which reduces or excludes anti-self reactivity, however, necessarily
involves impairment of immunity. While blood group A phenotype development thus
is associated with impaired formation of adaptive and innate immunoglobulins,
it promotes susceptibility to malaria infection via its intrinsic enzyme
functions, initiating a self-destructive glycosidic, phenotypic accommodation
of a "wrong eukaryote". In fact, blood group A phenotype-specific
GalNAc transferase activities, expressed by both cell surfaces and plasma
proteins, and serine/threonine kinases, which are imported from Plasmodium
falciparum into the red cell membrane, might provide the metabolic condition
for adhesion protein and rosette formation, assumingly based on heterologous O-glycosylation,
breaking a species barrier and completing the
"serine repeat antigen". Thus,
primarily the lack of blood group A-specific phenotype glycosylation(s) may
explain the obvious protection of the human blood group O(H) from severe
malaria infection, and suggests a new molecular definition of the therapeutic
target.