cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics
Creators: name: Lecommandeur, Emmanuelle
name: Cachón-González, Maria Begoña
name: Boddie, Susannah
name: McNally, Ben D.
name: Nicholls, Andrew W.
name: Cox, Timothy M.
name: Griffin, Julian L.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: lipidomics
metabolomics
lysosomal disorders
β-hexosaminidase
galactosylceramides
bis(monoacylglycero)phosphates
plasmalogens

description: Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B. SD is characterised by an accumulation of gangliosides and related glycolipids, mainly in the central nervous system, and progressive neurodegeneration. The underlying cellular mechanisms leading to neurodegeneration and the contribution of inflammation in SD remain undefined. The aim of the present study was to measure global changes in metabolism over time that might reveal novel molecular pathways of disease. We used liquid chromatography-mass spectrometry and 1H Nuclear Magnetic Resonance spectroscopy to profile intact lipids and aqueous metabolites, respectively. We examined spinal cord and cerebrum from healthy and Hexb−/− mice, a mouse model of SD, at ages one, two, three and four months. We report decreased concentrations in lipids typical of the myelin sheath, galactosylceramides and plasmalogen-phosphatidylethanolamines, suggesting that reduced synthesis of myelin lipids is an early event in the development of disease pathology. Reduction in neuronal density is progressive, as demonstrated by decreased concentrations of N-acetylaspartate and amino acid neurotransmitters. Finally, microglial activation, indicated by increased amounts of myo-inositol correlates closely with the late symptomatic phases of the disease.
Choice of Agricultural Credit in Nepal
Creators: name: Gupta, Vivek
name: Gautam, Tej K.
name: Bhandari, Basu D.
name: Gupta, Vivek
name: Gautam, Tej K.
name: Bhandari, Basu D.
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Agricultural Finance
subject: Community/Rural/Urban Development
subject: agricultural credit
subject: informal credit

description: Income generating activities play a vital role to improve the livelihood of rural people in developing countries. International donor agencies and national policy makers would like to see subsistence farming transformed into commercial agriculture to enhance the well beings of people in developing countries. In Nepal for the last two decades or so, farmers are incorporating income generating activities in subsistent farming systems. Most popular income generating activities include mushroom cultivation, sericulture, apiculture, and fish culture. Our objective in this paper is to use a multinomial logit model to determine the factors affecting the choice of income generating activities by Nepalese farmers. Some of the important explanatory variables used in this model are availability of water, inputs (such as seeds and disinfectants), technology, and market accessibility. We use 2012 census data available from the Agricultural Census of Nepal to conduct this analysis. Preliminary results indicated that availability of inputs and accessibility to markets are the major determinants in selecting income generation activities. The outcome of this study may help to promote ideal income generating activities for the benefit of rural farmers in Nepal or other developing countries.
Choice of Income Generating Activities by Nepalese Farmers
Creators: name: Gupta, Vivek
name: Bhandari, Basu D.
name: Gautam, Tej K.
name: Gupta, Vivek
name: Bhandari, Basu D.
name: Gautam, Tej K.
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: subsistence farming
subject: commercial agriculture
subject: cash crops

description: Nepal is predominantly an agricultural country. More than 35% of its GDP depends on agriculture. About 65% of Nepalese people rely agriculture for their livelihood. Agricultural credit plays a major role in agricultural development. Different sources are available in the agricultural credit market in Nepal. Formal sources include agricultural development bank, farmers’ cooperatives, and other financial institutions while informal sources include borrowing from farmers group, women group, and money lender individual (mostly relatives). Several factors might play a role in selecting different credit sources : types of agricultural commodities, buying different operating inputs (machinery, seeds, and fertilizers), buying fixed inputs (machinery and equipment), interest rate, and reimbursement plan. In this paper, we want to determine which source is the most popular among the farmers of Nepal and explain why that particular source is a choice for farmers. We use Nepalese agricultural census data for the fiscal year 2011/12 and multinomial logit model for this analysis. The result of this study will explain the factors affecting the choice of agricultural credit and most popular credit sources in Nepal and come up with some policy recommendations. This would enrich literature in explaining the choice of agricultural credit sources in other developing countries like Nepal.
Listronotus wallacei
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus wallacei

description: Listronotus wallacei (Stockton, 1963)
 Hyperodes wallacei Stockton, 1963: 140 (type locality: USA: Florida, Dunellon; type material: H: USNM). Listronotus wallacei; O’Brien and Wibmer, 1982: 71.
 Distribution. Southeastern USA (O’Brien and Wibmer, 1982; Anderson, 1992).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 48, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
(Super)Oscillator on CP(N) and Constant Magnetic Field
Creators: name: Bellucci, Stefano
name: Nersessian, Armen
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We define the "maximally integrable" isotropic oscillator on CP(N) and discuss its various properties, in particular, the behaviour of the system with respect to a constant magnetic field. We show that the properties of the oscillator on CP(N) qualitatively differ in the N>1 and N=1 cases. In the former case we construct the ``axially symmetric'' system which is locally equivalent to the oscillator. We perform the Kustaanheimo-Stiefel transformation of the oscillator on CP(2) and construct some generalized MIC-Kepler problem. We also define a N=2 superextension of the oscillator on CP(N) and show that for N>1 the inclusion of a constant magnetic field preserves the supersymmetry of the system.
description: 12 pages, one important statement corrected, PACS numbers: 03.65-w, 11.30.Pb
Quantum Optimization with a Novel Gibbs Objective Function and Ansatz Architecture Search
Creators: name: Li, Li
name: Fan, Minjie
name: Coram, Marc
name: Riley, Patrick
name: Leichenauer, Stefan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Quantum Approximate Optimization Algorithm (QAOA) is a standard method for combinatorial optimization with a gate-based quantum computer. The QAOA consists of a particular ansatz for the quantum circuit architecture, together with a prescription for choosing the variational parameters of the circuit. We propose modifications to both. First, we define the Gibbs objective function and show that it is superior to the energy expectation value for use as an objective function in tuning the variational parameters. Second, we describe an Ansatz Architecture Search (AAS) algorithm for searching the discrete space of quantum circuit architectures near the QAOA to find a better ansatz. Applying these modifications for a complete graph Ising model results in a $244.7\%$ median relative improvement in the probability of finding a low-energy state while using $33.3\%$ fewer two-qubit gates. For Ising models on a 2d grid we similarly find $44.4\%$ median improvement in the probability with a $20.8\%$ reduction in the number of two-qubit gates. This opens a new research field of quantum circuit architecture design for quantum optimization algorithms.
Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study
Creators: name: Petry, Clive J.
name: Ong, Ken K.
name: Hughes, Ieuan A.
name: Dunger, David B.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: adiposity
development
fetal growth
gestational diabetes
minerals
vitamins

description: Multiple micronutrient supplementation (MMS) in pregnancy has previously been associated with positive effects on fetal growth, but its value in high-income countries remains controversial. In this study, we investigated effects of pregnancy MMS on offspring size at birth and adiposity, along with risks of various maternal outcomes of pregnancy, using the prospective Cambridge Baby Growth Study. Maternal MMS was reported in 528 out of 970 women who completed pregnancy questionnaires. Gestational diabetes (GDM) was assessed using results from 75 g oral glucose tolerance tests at week 28 of pregnancy. Offspring size at birth was assessed using standard anthropometric measurements and adiposity using skinfold calipers. MMS was associated with increased risk of developing GDM (risk ratio = 1.86 (1.13−3.08), p = 0.02), as well as increased offspring size at birth in terms of weight (p = 0.03), head circumference (p = 0.04), and flank, and subscapular and triceps skinfold thicknesses (p = 0.04, 0.03, and 0.003, respectively). There was no association with quadriceps skinfold thickness (p = 0.2), suggesting that the increased adiposity was partially regionalized. In women who underwent oral glucose tolerance testing, nearly all of these associations were attenuated by adjusting for GDM. These results suggest that the increased offspring size at birth, including (regionalized) adiposity associated with pregnancy, and MMS may be partially related to the development of GDM.
The Ising Model on a Dynamically Triangulated Disk with a Boundary Magnetic Field
Creators: name: McGuire, Scott
name: Catterall, Simon
name: Bowick, Mark
name: Warner, Simeon
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use Monte Carlo simulations to study a dynamically triangulated disk with Ising spins on the vertices and a boundary magnetic field. For the case of zero magnetic field we show that the model possesses three phases. For one of these the boundary length grows linearly with disk area, while the other two phases are characterized by a boundary whose size is on the order of the cut-off. A line of continuous magnetic transitions separates the two small boundary phases. We determine the critical exponents of the continuous magnetic phase transition and relate them to predictions from continuum 2-d quantum gravity. This line of continuous transitions appears to terminate on a line of discontinuous phase transitions dividing the small boundary phases from the large boundary phase. We examine the scaling of bulk magnetization and boundary magnetization as a function of boundary magnetic field in the vicinity of this tricritical point.
description: 32 pages, latex
Additional file 1 of Management practices in community-based HIV prevention organizations in Nigeria
Creators: name: Akeju, David
name: Nerissa Nance
name: Salas-Ortiz, Andrea
name: Ayoola Fakunmoju
name: Idoteyin Ezirim
name: Adejumoke G. Oluwayinka
name: Omoregie Godpower
name: Bautista-Arredondo, Sergio
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Sociodemographic information of respondents. This Table shows the sociodemographic description of participants.
On the nature of the core of $α$ Centauri A: the impact of the metallicity mixture
Creators: name: Nsamba, Benard
name: Campante, Tiago L.
name: Monteiro, Mário J. P. F. G.
name: Cunha, Margarida S.
name: Sousa, Sérgio G.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Forward asteroseismic modelling plays an important role towards a complete understanding of the physics taking place in deep stellar interiors. With a dynamical mass in the range over which models develop convective cores while in the main sequence, the solar-like oscillator $α$ Centauri A presents itself as an interesting case study. We address the impact of varying the metallicity mixture on the determination of the energy transport process at work in the core of $α$ Centauri A. We find that $\gtrsim$ 70$\%$ of models reproducing the revised dynamical mass of $α$ Centauri A have convective cores, regardless of the metallicity mixture adopted. This is consistent with the findings of Nsamba et al., where nuclear reaction rates were varied instead. Given these results, we propose that $α$ Centauri A be adopted in the calibration of stellar model parameters when modelling solar-like stars with convective cores.
description: 12 pages, 3 figures, 4 tables, Accepted for publication in Front. Astron. Space Sci. - Stellar and Solar Physics
AF - Manual de Casos de Estudos
Creators: name: Ramos, Sofia
Publisher: name: Zenodo
Year: 2025

description: O presente manual de casos de estudo é composto por 26 casos reais de relevância técnica e científica e que traduzem a aproximação à realidade empresarial e económica Portuguesa, tendo por base as evidências constantes nos capítulos da unidade curricular de Auditoria Financeira (plano de estudos 2025) e corresponde, por sua vez, ao tratamento da bibliografia referenciada no Guia de Funcionamento da UC, bem como na restante legislação, normas, regulamentos, informações, avisos e outros documentos disponibilizado na plataforma de e-learning, tendo como objetivos:

Desenvolver conhecimentos e competências para a importância da auditoria na credibilização da informação financeira no contexto das normas, nacionais e internacionais;

Obter aptidões para, de forma eficiente e eficaz, incrementar a sua capacidade de resolução de problemas no âmbito da área da contabilidade para a construção e fundamentação da sua própria argumentação face à gestão;

Identificar e discutir os objetivos específicos de uma organização integrada num sector económico em Portugal e na UE;

Promover uma mente interrogativa na abordagem à organização, formando-se como um profissional competente na área da auditoria e na própria gestão, e que, ainda, comunica e apresenta recomendações de modo conciso e lógico.
Additional file 3 of Management practices in community-based HIV prevention organizations in Nigeria
Creators: name: Akeju, David
name: Nerissa Nance
name: Salas-Ortiz, Andrea
name: Ayoola Fakunmoju
name: Idoteyin Ezirim
name: Adejumoke G. Oluwayinka
name: Omoregie Godpower
name: Bautista-Arredondo, Sergio
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Supplementary Table 2. Code definitions and frequencies. This Table shows the definition of the codes analyzed and frequency of appearance.
Macrostyphlus howdenorum Morrone 1994
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Macrostyphlus
Macrostyphlus howdenorum

description: Macrostyphlus howdenorum Morrone, 1994
 Macrostyphlus howdenorum Morrone, 1994c: 10 (type locality: Ecuador: Napo, Quito-Baeza Road, 4100 m; type material: H: CMNC and P: 1 CMNC).
 Distribution. Northern Ecuador (Morrone, 1994c).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 49, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Macrostyphlus peruvianus Morrone 1994
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Macrostyphlus
Macrostyphlus peruvianus

description: Macrostyphlus peruvianus Morrone, 1994
 Macrostyphlus peruvianus Morrone, 1994c: 10 (type locality: Peru: Cuzco Department, Pillahuata, Manu Road, km 128; type material: H: FMNH).
 Distribution. Southern Peru (Morrone, 1994c).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 49, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Single Spin Asymmetry Parameter from Deeply Virtual Compton Scattering of Hadrons up to Twist-3 accuracy: I. Pion case
Creators: name: Anikin, I. V.
name: Binosi, D.
name: Medrano, R.
name: Noguera, S.
name: Vento, V.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The study of deeply virtual Compton scattering has shown that electromagnetic gauge invariance requires, to leading order, not only twist two but additional twist three contributions. We apply this analysis and, using the Ellis-Furmanski-Petronzio factorization scheme, compute the single (electron) spin asymmetry arising in the collision of longitudinally polarized electrons with hadrons up to twist 3 accuracy. In order to simplify the kinematics we restrict the actual calculation to pions in the chiral limit. The process is described in terms of the generalized parton distribution functions which we obtain within a bag model framework.
description: 18 pages, Latex
North Dakota Potato Industry
Creators: name: Berwick, Mark
name: Anderson, Tara
name: Ripplinger, David
name: Bitzan, John D.
name: Berwick, Mark
name: Anderson, Tara
name: Ripplinger, David
name: Bitzan, John D.
Publisher: name: Unknown
Year: 2001
Subjects: Agribusiness
Crop Production/Industries
Land Economics/Use

description: In an attempt to increase net returns from farming efforts and stabilize agricultural commodities, rural communities are viewing value-added processing as a possible solution. Many attempts have been made at the value-added concept, and recently adding potato production under irrigation has changed farming for some North Dakota producers. The potato industry is meeting consumer demands for more efficient and less time consuming methods of cooking by offering a wider variety of convenient processed potato items. The different uses of potatoes determines processor locations and movement of the raw product. However, the location of processing plants and warehouses impact highway demand and truck use. A network flow model was developed to estimate the truck traffic generated by the potato industry : The model uses some of the steps implemented by Denver Tolliver of UGPTI in developing a Prototype Corn Highway Network Model for Southeastern North Dakota. A network model is a representation of supply and destination nodes and the transportation links. The most important findings is the reduction in production in northeastern North Dakota, the traditional location of potato production and the introduction of irrigated acreage in the central and south central part of the state. The processors demand a uniform quality product which can best be controlled under irrigation. Continued irrigation development will increase tonnage product from the land. This production may not be potatoes, but whatever the crop, the additional tonnage will have greater impacts on the North Dakota highway system. Development of flow models to coincide with NASS production data will provide valuable insight for North Dakota highway planners.
Prolonged Diagnostic Intervals as Marker of Missed Diagnostic Opportunities in Bladder and Kidney Cancer Patients with Alarm Features: A Longitudinal Linked Data Study
Creators: name: , Zhou
name: , Walter
name: Singh
name: , Hamilton
name: , Abel
name: , Lyratzopoulos
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: bladder cancer
kidney cancer
early diagnosis
diagnostic timeliness
missed opportunity

description: Background: In England, patients who meet National Institute for Health and Care Excellence (NICE) guideline criteria for suspected cancer should receive a specialist assessment within 14 days. We examined how quickly bladder and kidney cancer patients who met fast-track referral criteria were actually diagnosed. Methods: We used linked primary care and cancer registration data on bladder and kidney cancer patients who met fast-track referral criteria and examined the time from their first presentation with alarm features to diagnosis. Using logistic regression we examined factors most likely to be associated with non-timely diagnosis (defined as intervals exceeding 90 days), adjusting for age, sex and cancer type, positing that such occurrences represent missed opportunity for timely referral, possibly due to sub-optimal guideline adherence. Results: 28%, 42% and 31% of all urological cancer patients reported no, one or two or more relevant symptoms respectively in the year before diagnosis. Of the 2105 patients with alarm features warranting fast-track assessment, 1373 (65%) presented with unexplained haematuria, 382 (18%) with recurrent urinary tract infections (UTIs), 303 (14%) with visible haematuria, and 45 (2%) with an abdominal mass. 27% overall, and 24%, 45%, 18% and 27% of each group respectively, had a non-timely diagnosis. Presentation with recurrent UTI was associated with longest median diagnostic interval (median 83 days, IQR 43−151) and visible haematuria with the shortest (median 50 days, IQR 30−79). After adjustment, presentation with recurrent UTIs, being in the youngest or oldest age group, female sex, and diagnosis of kidney and upper tract urothelial cancer, were associated with greater odds of non-timely diagnosis. Conclusion: More than a quarter of patients presenting with fast-track referral features did not achieve a timely diagnosis, suggesting inadequate guideline adherence for some patients. The findings highlight a substantial number of opportunities for expediting the diagnosis of patients with bladder or kidney cancers.
‘Body-objects’ and personhood in the Iron and Viking Ages: processing, curating, and depositing skulls in domestic space
Creators: name: Eriksen, Marianne Hem
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: This article explores practices of processing, displaying, and depositing human and animal crania in built environments and wetlands in the long Iron Age of Scandinavia. The paper first reports on a dataset of a range of practices targeting heads over the first millennium CE, with a particular focus on deposition of crania in built environments. I subsequently present a two-fold analysis of these data: an exploration of how reworking bodies into cranial objects transformed personhood in complex ways, and a discussion of how the particular practices afforded to the head connects with practices of placemaking and atmospheric intervention. I consider reworked, displayed and deposited heads as ‘body-objects’ – a different kind of being than ‘person’, ’animal’ or ‘thing’ that breaks open some existing assumptions of the constitution of bodies and persons in Iron and Viking Age Scandinavia.
Strong optical coupling combines isolated scatterers into dimer
Creators: name: Dmitriev, Alexey A.
name: Rybin, Mikhail V.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We analyze the transition between different coupling regimes of two dielectric rods, which occurs at a critical distance between them. The hallmark of strong coupling regime is the peak splitting effect observed in spectra. Here we comprehensively evaluate the critical distance as a function of the rod permittivity using a number of different approaches. The scattering spectra of the two rods in dependence on the distance demonstrate the weak to strong coupling transition. We start the analysis by introducing a region of a tidal energy flux around a single isolated rod (the region is related to the near field) and demonstrate that its effective radius corresponds to the critical distance obtained from the scattering spectra. Next, we study the eigenfrequencies of the dimer as functions of distance by 'diagonalizing' the coupled multipole matrix. In order to find an analytical formula for the critical distance, we consider the problem under several approximations, which yield similar results.
description: 10 pages, 6 figures
Penrose Limits of RG Fixed Points and PP-Waves with Background Fluxes
Creators: name: Corrado, Richard
name: Halmagyi, Nick
name: Kennaway, Kristian D.
name: Warner, Nicholas P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a family of pp-wave solutions of IIB supergravity. This family has a non-trivial, constant 5-form flux, and non-trivial, (light-cone) time-dependent RR and NS-NS 3-form fluxes. The solutions have either 16 or 20 supersymmetries depending upon the time dependence. One member of this family of solutions is the Penrose limit of the solution obtained by Pilch and Warner as the dual of a Leigh-Strassler fixed point. The family of solutions also provides indirect evidence in support of a recent conjecture concerning a large N duality group that acts on RG flows of N=2 supersymmetric, quiver gauge theories.
description: 20 pages, harvmac, refs. added, version to appear in Adv.Theor.Math.Phys
Magnetic Dissipation of Near-Wall Turbulent Coherent Structures in Magnetohydrodynamic Pipe Flows
Creators: name: Moriconi, L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Applied Physics (physics.app-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Relaminarization of wall-bounded turbulent flows by means of external static magnetic fields is a long-known phenomenon in the physics of electrically conducting fluids at low magnetic Reynolds numbers. Despite the large literature on the subject, it is not yet completely clear what combination of the Hartmann ($M$) and the Reynolds number has to be used to predict the laminar-turbulent transition in channel or pipe flows fed by upstream turbulent flows free of magnetic perturbations. Relying upon standard phenomenological approaches related to mixing length and structural concepts, we put forward that $M/R_τ$, where $R_τ$ is the friction Reynolds number, is the appropriate controlling parameter for relaminarization, a proposal which finds good support from available experimental data.
description: 7 pages, 3 figures - To be published in Physical Review E
Macrostyphlus sturmi Morrone 1994
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Macrostyphlus
Macrostyphlus sturmi

description: Macrostyphlus sturmi Morrone, 1994
 Macrostyphlus sturmi Morrone, 1994c: 10 (type locality: Colombia: Bogotá, Monserrate, 3200 m; type material: H: ICNB and P: 1 ICNB).
 Distribution. Central Colombia (Morrone, 1994c).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 49, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Additional file 1 of Efficacy of preemptive intercostal nerve block on recovery in patients undergoing video-assisted thoracic lobectomy
Creators: name: Chen, Shaojuan
name: Guo, Zhihua
name: Wei, Xin
name: Chen, Zhenzhu
name: Liu, Na
name: Yin, Weiqiang
name: Lan, Lan
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mental Health

description: Supplement table. 1 Comparison of intraoperative conditions.
Exceptional points for resonant states on parallel circular dielectric cylinders
Creators: name: Abdrabou, Amgad
name: Lu, Ya Yan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Exceptional points (EPs) are special parameter values of a non-Hermitian eigenvalue problem where eigenfunctions corresponding to a multiple eigenvalue coalesce. In optics, EPs are associated with a number of counter-intuitive wave phenomena, and have potential applications in lasing, sensing, mode conversion and spontaneous emission processes. For open photonic structures, resonant states are complex-frequency solutions of the Maxwell's equations with outgoing radiation conditions. For open dielectric structures without material gain or loss, the eigenvalue problem for resonant states can have EPs, since it is non-Hermitian due to radiation losses. For applications in nanophotonics, it is important to understand EPs for resonant states on small finite dielectric structures consisting of conventional dielectric materials. To achieve this objective, we study EPs of resonant states on finite sets of parallel infinitely-long circular dielectric cylinders with subwavelength radii. For systems with two, three and four cylinders, we develop an efficient numerical method for computing EPs, present examples for second and third order EPs, and highlight their topological features. Our work provides insight to understanding EPs on more complicated photonic structures, and can be used as a simple platform to explore applications of EPs.
Implications of symmetries in the scalar sector
Creators: name: Haber, Howard E.
name: Ogreid, O. M.
name: Osland, P.
name: Rebelo, M. N.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Symmetries play a very important rôle in Particle Physics. In extended scalar sectors, the existence of symmetries may permit the models to comply with the experimental constraints in a natural way, and at the same time reduce the number of free parameters. There is a strong interplay among internal symmetries of the scalar potential, its CP properties and mass degeneracies of the physical scalars. Some of these aspects were discussed in this talk.
description: 8 pages, to be published in the Proceedings of DISCRETE2018: 6th Symposium on Prospects in the Physics of Discrete Symmetries, 26-30 Nov 2018. Vienna, Austria
Sturmian Words and the Permutation that Orders Fractional Parts
Creators: name: O'Bryant, Kevin
Publisher: name: arXiv
Year: 2002
Subjects: subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 68R15; 11J71; 05E99

description: A Sturmian word is a map W from the natural numbers into {0,1} for which the set of {0,1}-vectors F_n(W):={(W(i),W(i+1),...,W(i+n-1))^T : i \ge 0} has cardinality exactly n+1 for each positive integer n. Our main result is that the volume of the simplex whose n+1 vertices are the n+1 points in F_n(W) does not depend on W. Our proof of this motivates studying algebraic properties of the permutation $π$ (depending on an irrational x and a positive integer n) that orders the fractional parts {1 x}, {2 x}, ..., {n x}, i.e., 0 < {π(1) x} < {π(2) x} < ... < {π(n) x} < 1. We give a formula for the sign of $π$, and prove that for every irrational x there are infinitely many n such that the order of $π$ (as an element of the symmetric group S_n) is less than n.
description: 20 pages, 1 figure, Mathematica notebook available from author
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study
Creators: name: Mozgunov, Pavel
name: Knight, Rochelle
name: Barnett, Helen
name: Jaki, Thomas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: dose-escalation
combination study
modelling assumption
interaction

description: There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation decisions during the trials. The majority of these proposals are model-based: a parametric combination-toxicity relationship is fitted as data accumulates. Various parameter shapes were considered but the unifying theme for many of these is that typically between 4 and 6 parameters are to be estimated. While more parameters allow for more flexible modelling of the combination-toxicity relationship, this is a challenging estimation problem given the typically small sample size in Phase I trials of between 20 and 60 patients. These concerns gave raise to an ongoing debate whether including more parameters into combination-toxicity model leads to more accurate combination selection. In this work, we extensively study two variants of a 4-parameter logistic model with reduced number of parameters to investigate the effect of modelling assumptions. A framework to calibrate the prior distributions for a given parametric model is proposed to allow for fair comparisons. Via a comprehensive simulation study, we have found that the inclusion of the interaction parameter between two compounds does not provide any benefit in terms of the accuracy of selection, on average, but is found to result in fewer patients allocated to the target combination during the trial.
Nature of Risk Associated with Rainfall and its Effect on Farming- A Case Study of Kurnool District Andhra Pradesh
Creators: name: Malya, Meenakshi M.
name: Rajagopalan, R.
name: Malya, Meenakshi M.
name: Rajagopalan, R.
Publisher: name: Unknown
Year: 1964
Subjects: Environmental Economics and Policy
Farm Management

description: The paper poses the following questions: (i) What is the nature of risk associated with rainfall? (ii) Is there any associated between the reactions of the farmer as seen from extent of cropping and cropping pattern and the level of rainfall? (iii) What is the degree of loss incurred by the farmer due to uncertain rainfall?
title: Pineapple :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: New Varieties of Plants
Pineapple

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Using Wine Quality Differential in Grapes Pricing
Creators: name: Golan, Amos
name: Shalit, Haim
name: Golan, Amos
name: Shalit, Haim
Publisher: name: Unknown
Year: 1985
Subjects: Crop Production/Industries

description: A model of pricing grapes is developed based on the hedonic hypothesis that wine produced from those grapes is valued by consumers for its quality characteristics. The model attempts to establish a set of producers pricing rules for quality characteristics in a cooperative framework. The model is then used to estimate the grape components affecting wine quality. Those characteristics are valued and a producer pricing for grapes is established.
Macrostyphlus venezolanus Morrone 1994
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Macrostyphlus
Macrostyphlus venezolanus

description: Macrostyphlus venezolanus Morrone, 1994
 Macrostyphlus venezolanus Morrone, 1994c: 12 (type locality: Venezuela: Mérida, Telef. Est. La Aguada, 3460 m; type material: H: CMNC and P: 2 CMNC and 1 MZFC).
 Distribution. Northwestern Venezuela (Morrone, 1994c).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 50, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP
Creators: name: Swain, Brendan M.
name: Guo, Dawei
name: Singh, Himansha
name: Rawlins, Philip B.
name: McAlister, Mark
name: Van Veen, Hendrik W.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/326/22/1434
/631/326/88
article

description: Funder: AstraZeneca PhD studentship
description: Funder: China Scholarship Council; doi: http://dx.doi.org/10.13039/501100004543
description: Funder: Cambridge Trust; doi: http://dx.doi.org/10.13039/501100003343
description: Abstract: Multidrug transporters can confer drug resistance on cells by extruding structurally unrelated compounds from the cellular interior. In transport assays, Hoechst 33342 (referred to as Hoechst) is a commonly used substrate, the fluorescence of which changes in the transport process. With three basic nitrogen atoms that can be protonated, Hoechst can exist as cationic and neutral species that have different fluorescence emissions and different abilities to diffuse across cell envelopes and interact with lipids and intracellular nucleic acids. Due to this complexity, the mechanism of Hoechst transport by multidrug transporters is poorly characterised. We investigated Hoechst transport by the bacterial major facilitator superfamily multidrug-proton antiporter LmrP in Lactococcus lactis and developed a novel assay for the direct quantitation of cell-associated Hoechst. We observe that changes in Hoechst fluorescence in cells do not always correlate with changes in the amount of Hoechst. Our data indicate that chemical proton gradient-dependent efflux by LmrP in cells converts populations of highly fluorescent, membrane-intercalated Hoechst in the alkaline interior into populations of less fluorescent, cell surface-bound Hoechst in the acidic exterior. Our methods and findings are directly relevant for the transport of many amphiphilic antibiotics, antineoplastic agents and cytotoxic compounds that are differentially protonated within the physiological pH range.
Chirality Correlation within Dirac Eigenvectors from Domain Wall Fermions
Creators: name: Blum, T.
name: Christ, N.
name: Cristian, C.
name: Dawson, C.
name: Liao, X.
name: Liu, G.
name: Mawhinney, R.
name: Wu, L.
name: Zhestkov, Y.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the dilute instanton gas model of the QCD vacuum, one expects a strong spatial correlation between chirality and the maxima of the Dirac eigenvectors with small eigenvalues. Following Horvath, {\it et al.} we examine this question using lattice gauge theory within the quenched approximation. We extend the work of those authors by using weaker coupling, $β=6.0$, larger lattices, $16^4$, and an improved fermion formulation, domain wall fermions. In contrast with this earlier work, we find a striking correlation between the magnitude of the chirality density, $|ψ^\dagger(x)γ^5ψ(x)|$, and the normal density, $ψ^\dagger(x)ψ(x)$, for the low-lying Dirac eigenvectors.
description: latex, 25 pages including 12 eps figures
Quickly Finding the Best Linear Model in High Dimensions
Creators: name: Sattar, Yahya
name: Oymak, Samet
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Information Theory (cs.IT)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We study the problem of finding the best linear model that can minimize least-squares loss given a data-set. While this problem is trivial in the low dimensional regime, it becomes more interesting in high dimensions where the population minimizer is assumed to lie on a manifold such as sparse vectors. We propose projected gradient descent (PGD) algorithm to estimate the population minimizer in the finite sample regime. We establish linear convergence rate and data dependent estimation error bounds for PGD. Our contributions include: 1) The results are established for heavier tailed sub-exponential distributions besides sub-gaussian. 2) We directly analyze the empirical risk minimization and do not require a realizable model that connects input data and labels. 3) Our PGD algorithm is augmented to learn the bias terms which boosts the performance. The numerical experiments validate our theoretical results.
The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy
Creators: name: Ježek, Jan
name: Cooper, Katrina F.
name: Strich, Randy
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: mitochondria
reactive oxygen species
cancer
chemotherapy
oxidative stress
stress signaling
mitochondrial dynamics
mitophagy
apoptosis
cyclin C

description: Cancer is one of the world’s deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent or impede the uncontrolled proliferation of malignant cells. Targeting tumors by inducing apoptosis is one of the pillars of cancer treatment. Changes in mitochondrial morphology precede intrinsic apoptosis, but mitochondrial dynamics has only recently been recognized as a viable pharmacological target. In many cancers, oncogenic transformation is accompanied by accumulation of elevated cellular levels of ROS leading to redox imbalance. Hence, a common chemotherapeutic strategy against such tumor types involves deploying pro-oxidant agents to increase ROS levels above an apoptotic death-inducing threshold. The aim of this chapter is to investigate the benefit of stimulating mitochondrial fission-dependent production of ROS for enhanced killing of solid tumors. The main question to be addressed is whether a sudden and abrupt change in mitochondrial shape toward the fragmented phenotype can be pharmacologically harnessed to trigger a burst of mitochondrial ROS sufficient to initiate apoptosis specifically in cancer cells but not in non-transformed healthy tissues.
Municipal Wastewater Treatment and Reuse: I. Treatment Optimization and Reuse for Regional Irrigation
Creators: name: Dinar, Ariel
name: Yaron, Dan
name: Dinar, Ariel
name: Yaron, Dan
Publisher: name: Unknown
Year: 1985
Subjects: Agricultural and Food Policy

description: Municipal wastewater warrants increased attention as a potential environmental pollution and a possible irrigation water source. A long-run mathematical programming model aimed at regional optimization with regard to plant capacity, treatment level, allocation of the effluent to the participating farms and cropping patterns at each farm is presented. The model is applied to an agricultural region in Israel which includes a town and several farms. The results indicate the necessity of a subsidy for regional cooperation and provide a regional setup of reusing municipal wastewater for irrigation. The optimal solution enables each farm to reallocate the fresh water quota among the different land sections, to cultivate new land areas and to expand the irrigated crops by using effluent. The acceptability of the regional optimal solution by the town and the farms is discussed in another paper.
Nacodius martitae Morrone 1994
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Nacodius
Nacodius martitae

description: Nacodius martitae Morrone, 1994
 Nacodius martitae Morrone, 1994e: 6 (type locality: Peru: D. La Libertad, 6 mi N Manachacui Valley; type material: H: CWOB and P: 2 AMNH, 8 CWOB, and 2 MZFC).
 Distribution. Northern Peru (Morrone, 1994e).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 50, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Annexin 1 Is a Component of eATP-Induced Cytosolic Calcium Elevation in Arabidopsis thaliana Roots
Creators: name: Mohammad-Sidik, Amirah
name: Sun, Jian
name: Shin, Ryoung
name: Song, Zhizhong
name: Ning, Youzheng
name: Matthus, Elsa
name: Wilkins, Katie A.
name: Davies, Julia M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: extracellular ATP
ADP
root
Arabidopsis
annexin 1
calcium
calcium channel
reactive oxygen species

description: Extracellular ATP (eATP) has long been established in animals as an important signalling molecule but this is less understood in plants. The identification of Arabidopsis thaliana DORN1 (Does Not Respond to Nucleotides) as the first plant eATP receptor has shown that it is fundamental to the elevation of cytosolic free Ca2+ ([Ca2+]cyt) as a possible second messenger. eATP causes other downstream responses such as increase in reactive oxygen species (ROS) and nitric oxide, plus changes in gene expression. The plasma membrane Ca2+ influx channels involved in eATP-induced [Ca2+]cyt increase remain unknown at the genetic level. Arabidopsis thaliana Annexin 1 has been found to mediate ROS-activated Ca2+ influx in root epidermis, consistent with its operating as a transport pathway. In this study, the loss of function Annexin 1 mutant was found to have impaired [Ca2+]cyt elevation in roots in response to eATP or eADP. Additionally, this annexin was implicated in modulating eATP-induced intracellular ROS accumulation in roots as well as expression of eATP-responsive genes.