cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
"ЖЕЛЕЗНЫЙ ЗАНАВЕС" БРОДВЕЯ: ПЬЕСА К. СИМОНОВА "ТАК И БУДЕТ!" В США (1947)
Creators: name: ГУДКОВ МАКСИМ
Publisher: name: Вопросы театра
Year: 2020
Subjects: АМЕРИКАНСКИЙ ТЕАТР
БРОДВЕЙ
СОВЕТСКАЯ ДРАМАТУРГИЯ
К.М. СИМОНОВ
ПЬЕСА "ТАК И БУДЕТ!"
"ХОЛОДНАЯ ВОЙНА"
"ЖЕЛЕЗНЫЙ ЗАНАВЕС"
AMERICAN THEATER
BROADWAY
SOVIET PLAYS
K. SIMONOV
PLAY AND SO IT WILL BE! (THE WHOLE WORLD OVER)
COLD WAR
IRON CURTAIN

description: В годы «холодной войны» одной из редких советских пьес, поставленных на американской сцене, была драма К.М. Симонова «Так и будет!» (под названием «По всему свету»). В статье анализируется влияние политической конъюнктуры и специфики коммерческого театра США на постановку отечественной пьесы. Сценическая судьба произведения Симонова за океаном исследуется в рамках социально-политического и культурного советско-американского макроконтекста послевоенного времени. На основе ранее неизвестных материалов (прежде всего, театральных рецензий из почти двух десятков американских газет, находящихся в фондах Нью-Йоркской публичной библиотеки исполнительских искусств, а также документов из личного фонда К.М. Симонова в РГАЛИ) дается анализ сценического воплощения драмы Симонова и его рецепции заокеанской критикой и зрителем.
"У МЕЙЕРХОЛЬДА ВОЛЧЬИ ГЛАЗА", ИЛИ "ОРГАНЫ ПОРЯДКА - ОСТАНОВИТЕСЬ". ВЫСТУПЛЕНИЕ В.Н. ЯХОНТОВА В ЗАЩИТУ ГОСТИМА (1928)
Creators: name: ИВАНОВ ВЛАДИСЛАВ
Publisher: name: Вопросы театра
Year: 2020
Subjects: ГОСТИМ
В.Э. МЕЙЕРХОЛЬД
ФРАНЦИЯ
М.А. ЧЕХОВ
НАРКОМПРОС
ГЛАВИСКУССТВО
СУБСИДИЯ
ЛИКВИДАЦИОННАЯ КОМИССИЯ
ДИСПУТ
ОБЩЕСТВЕННОСТЬ
GOSTIM
VSEVOLOD MEYERHOLD
FRANCE
MIKHAIL CHEKHOV
NARKOMPROS
GLAVISKUSSTVO
SUBSIDY
LIQUIDATION COMMISSION
PUBLIC

description: В 1928 г. существование ГосТИМа оказалось под угрозой. В отсутствие В.Э. Мейерхольда, который вел во Франции переговоры о зарубежных гастролях и лечился, Наркомпрос и Главискусство предприняли наступление на ГосТИМ, отказываясь продлевать с ним договор, требуя немедленного возвращения Мейерхольда в Москву, несмотря на болезнь. Перспектива закрытия революционного и экспериментального театра вызвала бурный общественный протест. На одном из диспутов со страстной и резкой речью в защиту театра выступил В.Н. Яхонтов.
КУЛАК И ПАЛКА КАК ОРУДИЯ МАГИИ И ИГРЫ
Creators: name: СТАХОРСКИЙ СЕРГЕЙ
Publisher: name: Вопросы театра
Year: 2020
Subjects: ОБРЯД
ИГРА
КУЛАЧНЫЙ БОЙ
ПАЛОЧНАЯ КОМЕДИЯ
ФАРС
БАЛАГАН
ПАРОДИЯ
БУРЛЕСК
RITE
GAME
PUGILISM
SLAPSTICK COMEDY
PHYSICAL COMEDY
FARCE
PARODY
BURLESQUE

description: В статье рассматриваются превращения древнейших орудий человека, кулака и палки, в инструменты обряда, празднества, состязания и актерской игры. Автор показывает, что кулак и палка, служа театру на протяжении всей его истории, а с начала ХХ века обслуживая и кинематограф, участвуют в образовании некоторых жанров (палочная комедия, фарс, слэпстик) и в формировании художественных приемов буффонады, бурлеска и пародии.
ОТ ДРАМЫ К ЭПОСУ ВНЕСЦЕНИЧЕСКИЕ ПЕРСОНАЖИ
Creators: name: ХАЙЧЕНКО ЕЛЕНА
Publisher: name: Вопросы театра
Year: 2020
Subjects: ЭПОС
ДРАМА
ВНЕСЦЕНИЧЕСКИЕ ПЕРСОНАЖИ
МИФ
РЕМАРКА
ИНСЦЕНИРОВКА
EPIC
DRAMA
OFF-STAGE CHARACTER
MYTH
REMARK
DRAMATIZATION

description: Статья посвящена взаимодействию между эпосом и драмой в театральном искусстве со времен Древней Греции и до сегодняшнего дня. По мнению автора, внесценические персонажи становятся маркерами эпического расширения действия в драматургии и театре.
ДИКЦИЯ АКТЕРА РУССКОГО ТЕАТРА (КОНЕЦ XVIII-XIX ВВ.) КАК ОТРАЖЕНИЕ ОБЩИХ ЭСТЕТИЧЕСКИХ УСЛОВИЙ И ВРЕМЕНИ
Creators: name: ДВИЗОВА ЕЛЕНА
Publisher: name: Вопросы театра
Year: 2020
Subjects: ПРОИЗНОШЕНИЕ
ДЕКЛАМАЦИЯ
СЦЕНИЧЕСКАЯ РЕЧЬ
ОБРАЗОВАНИЕ
РЕЧЕВОЕ ИСКУССТВО
PRONUNCIATION
RECITATION
STAGE SPEECH
EDUCATION
SPEECH ART

description: Основное содержание исследования составляет анализ материалов театральных деятелей, критиков и актеров русского театра, связанный с проблемой дикционной выразительности актера в период конца XVIII-XIX вв. Выявлено, что в эту эпоху характер речи и качество дикции актера на сцене в общем и целом зависел от театральной эстетики времени. Проанализированные факты помогли установить: понятия «дикция» и «декламация» часто выступали синонимами, что не способствовало детальному анализу технической стороны речи. Переходный период - уход от декламации к живой разговорной речи - был связан с эстетическими издержками (плохая слышимость, отсутствие четкости и ясности), так как актерская речевая работа не всегда подкреплялась художественным ее компонентом (осмысление авторского текста, психологический разбор роли, эмоциональная окраска), часто играли «под суфлера». Но заданный вектор -живое слово на сцене - способствовал необходимости создания методики сценической речи как неотъемлемой составляющей актерского мастерства.
Coherent state path integral for the harmonic oscillator and a spin particle in a constant magnetic field
Creators: name: Bergeron, Mario
Publisher: name: University of British Columbia
Year: 2010

description: The definition and formulas for the harmonic oscillator coherent states and spin coherent states are reviewed in detail. The path integral formalism is also reviewed with its relation and the partition function of a sytem is also reviewed. The harmonic oscillator coherent state path integral is evaluated exactly at the discrete level, and its relation with various regularizations is established. The use of harmonic oscillator coherent states and spin coherent states for the computation of the path integral for a particle of spin s put in a magnetic field is caried out in several ways, and a careful analysis of infinitesimal terms (in 1/N where TV is the number of time slices) is done explicitly. The theory of the magnetic monopole and its relation with the spin system are explained, and the equivalence of these two system is established up to infinitesimal order by the introduction of an exterior interaction to the monopole. This gives a new representation of a coherent state path integral in terms of a more familiar Feynman path integral. The coefficient of the topological term in the spin system appears explicitly without ambiguity, as being 2s.
title: Frühwarnsystem für gefährdete Staudämme
Creators: name: Jorzik, Oliver
name: Kraudzun, Henning
Publisher: name: Deutsches GeoForschungsZentrum GFZ
Year: 2020

description: Weltweit sind viele Staudämme durch Erosionsprozesse, Materialermüdung oder Erdbeben ihr ihrer Standfestigkeit gefährdet. Ein deutsch-kirgisisches Forscherteam will mögliche Schäden frühzeitig erkennen und entwickelt dazu ein innovatives Überwachungs- und Frühwarnsystem.
Planning to meet the costs of managing research data to be FAIR
Creators: name: Whyte, Angus
name: Davidson, Joy
name: O'Connor, Ryan
name: Montesanti, Annalisa
Publisher: name: Zenodo
Year: 2021

description: This presentation was held as part of the SSHOC DARIAH Train-the-trainer RDM Bootcamp held in February 2021 (see Zenodo community sshocdariahtrainerrdmbootcamp) This upload contains the slides of the session "Planning to meet the costs of managing research data to be FAIR". This session aims to offer training resources to adapt to your institutional context, helping researchers to do the following: Understand why they should budget for the costs of making data FAIR, and keeping it FAIR, and include these costs in grant applications Appreciate the benefits that services may provide to justify their costs Know about the different kinds of data management costs, including costs that funding bodies may allow to be charged to projects Apply a costing guide to help budget for the costs that may arise in preparing data to be FAIR Share experiences and expectations about costing the preparation of FAIR data
Additional file 5 of From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses
Creators: name: Biao, Tang
name: Cai-feng, He
name: Xiao-hong, Lu
name: Xiao-li, Chang
name: Wen-bei, Liu
name: Jun, Wang
name: Chao, Ci
name: Tao, Yuan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Figure S2. KEGG pathways were generated based on the differentially expressed proteins between Bowen disease and healthy control.
Dealing with third party data coming from cultural heritage institutions
Creators: name: Schuster, Kristen
Publisher: name: Zenodo
Year: 2021

description: This presentation was held as part of the SSHOC DARIAH Train-the-trainer RDM Bootcamp held in February 2021 (see Zenodo community sshocdariahtrainerrdmbootcamp) This upload contains the slides of the presentation of the introduction to "Dealing with third party data coming from cultural heritage institutions". The session will start with a short summary of an ongoing research project exploring strategies practitioners and researchers use to communicate and collaborate and, ideally, share data based on mutually understood data management strategies. Based on this summary, discussion questions for participants will be posed, and the follow up session will focus on collaboratively discussing and exploring RDM practices. A key goal for this workshop is to present, review and discuss strategies for enhancing communication about data management across disciplines within the DH and cultural heritage communities.
Didactics - 7 steps of concept development
Creators: name: Helbig, Kerstin
Publisher: name: Zenodo
Year: 2021

description: This presentation was held as part of the SSHOC DARIAH Train-the-trainer RDM Bootcamp held in February 2021 (see Zenodo community sshocdariahtrainerrdmbootcamp) This upload contains the slides of the presentation for the didactics session held on the second day of the bootcamp. In this session, Kerstin Helbig (Humboldt-Universität zu Berlin, Germany) will take participants through the seven steps of concept development. Trainers can apply these steps to develop and improve their training and to maximise their training success.
Additional file 7 of From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses
Creators: name: Biao, Tang
name: Cai-feng, He
name: Xiao-hong, Lu
name: Xiao-li, Chang
name: Wen-bei, Liu
name: Jun, Wang
name: Chao, Ci
name: Tao, Yuan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7. The raw data of 8 proteins in Western blot.
การประกอบสร้างวรรณกรรมการเมืองเรื่องสั้นรางวัลพานแว่นฟ้า
Creators: name: เกศราพร พรหมนิมิตกุล
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2557
Subjects: วรรณกรรมการเมือง, เรื่องสั้นรางวัลพานแว่นฟ้า, การประกอบสร้าง

description: 6, 33, วารสารมนุษยศาสตร์และสังคมศาสตร์  มหาวิทยาลัยมหาสารคาม
ปัจจัยลักษณะของงานที่มีผลต่อความผูกพันของบุคลากรทางสายวิชาการมหาวิทยาลัยราชภัฏนครปฐม
Creators: name: นิภาพรรณ เจนสันติกุล
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2557
Subjects: อัตลักษณ์ของงาน, ความผูกพัน, บุคลากรทางสายวิชาการ

description: 6, 33, วารสารมนุษยศาสตร์และสังคมศาสตร์  มหาวิทยาลัยมหาสารคาม
Additional file 4 of Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression
Creators: name: Chen, Qiang
name: Jiao, Jiuyang
name: Wang, Youyuan
name: Mai, Zhihui
name: Ren, Jing
name: He, Sijie
name: Li, Xiaolan
name: Chen, Zheng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 4.
Acaricidal activities of crude extract derived from Annona squamosa Linnaeus leaves against cattle tick, Rhipicephalus microplus Canestrini (Acari: Ixodidea)
Creators: name: Bounthavy Vongkhamchanh
Publisher: name: Mahasarakham University
Year: 2014
Subjects: Rhipicephalus microplus, Annona squamosa Linn., crude plant extract, acaricide, biocontrol

description: 2, 33, Journal of SCIENCE and TECHNOLOGY Mahasarakham University
Die Entstehung der Homo- und der Heterosexuellen
Creators: name: Trumbach, Randolph
name: Hekma, Gert
name: Oosterhuis, Harry
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 3 (1998): Homosexualiäten
Andrew Hewitt, Political Inversions. Homo- sexuality, Fascism, and the Modemist lmaginary, Stanford: Stanford University Press, 1996.
Creators: name: Oosterhuis, Harry
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 3 (1998): Homosexualiäten
Additional file 1 of From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses
Creators: name: Biao, Tang
name: Cai-feng, He
name: Xiao-hong, Lu
name: Xiao-li, Chang
name: Wen-bei, Liu
name: Jun, Wang
name: Chao, Ci
name: Tao, Yuan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. The clinical characteristics of 6 enrolled individuals for independent verification.
Peter Gay, Die Macht des Herzens. Das 19. Jahrhundert und die Erforschung des Ich . Aus dem Englischen von Ulrich Enderwitz, Monika Noll u. Rolf Schubert, München: C.H. Beck, 1997.
Creators: name: Regener, Susanne
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 3 (1998): Homosexualiäten
Additional file 2 of Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway
Creators: name: Zhong, Ying
name: Li, Fangyuan
name: Zhang, Sumei
name: Yang, Zhenli
name: Ren, Xinyu
name: Cao, Xi
name: Xu, Yali
name: Guo, Dan
name: Zhou, Yidong
name: Mao, Feng
name: Shen, Songjie
name: Sun, Qiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S2. List of primers for RT-qPCR.
title: Associations of digital media use and sexual activity
title: Associations of digital media use, in-person contact, and sexual activity
titleType: AlternativeTitle
Creators: name: Burghardt, Juliane
name: Gradl, Silvia
name: Schütt, Thomas
name: Krüger, Elisabeth
name: Stieger​, Stefan
Publisher: name: PsychArchives
Year: 2025
Subjects: subject: sexual acivity
subject: digital media
subject: social media
subject: digital games
subject: social integration
subject: social support
subject: 150

description: Intense digital media use was suspected to disrupt relationships and therefore reduce sexual activity. This study explores associations between digital media use, sexual activity, and in-person contact. The cross-sectional study analyzed quasi-representative data from 2064 participants aged 18 to 69 years living in Austria. Participants reported digital media use per day, in-person contact with friends per week, frequency of sexual activity in the past year, number of sexual partners, and satisfaction with frequency of sexual activity. More intense digital media use was associated with less sex; this effect was small. Additionally, more in-person contact was associated with more sex and more sex partners. Among men who have a partner, higher digital media use was associated with too much sex. The same was true for single women. Further, high digital media use was associated with not enough sex in women irrespective of partnership. Nearly half of participants (45%) reported to have less sex than they wanted. Social support and social integration have frequently shown positive effects on well-being and are apparently also positively associated with more sex.
A microscopic modeling of phonon dynamics and charge response in NdCuO
Creators: name: Bauer, Thomas
name: Falter, Claus
Publisher: name: arXiv
Year: 2007
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A description of phonon dynamics and charge response of the $n$-doped high-temperature superconductor (HTSC) NdCuO is presented based upon a microscopic modeling of the electronic density response. This is accomplished starting from the insulating state via the underdoped strange metallic to the more conventional metallic state by consecutive orbital selective incompressibility-compressibility transitions in terms of strict sum rules for the charge response. The approach proposed in this work for the $n$-doped HTSC's modifies the modeling recently applied to the $p$-doped compounds and expresses an electron-hole asymmetry introduced by doping. A qualitative physical picture consistent with our modeling of the electronic state in the cuprates is given in which a sufficiently broad set of orbital degrees of freedom, i.e. Cu3d/$4s$ and O$2p$ is essential. Within the framework of linear response theory we calculate full phonon dispersion curves in the different phases. In particular, the strongly doping dependent anomalous high-frequency oxygen bond-stretching modes (OBSM) found experimentally in the $p$-doped HTSC's and also recently for $n$-doped Nd$_{1.85}$Ce$_{0.15}$CuO$_{4}$ are investigated and compared with experimental results from inelastic neutron scattering and inelastic x-ray scattering, respectively. We calculate an anticrossing scenario for the OBSM in $n$-doped NdCuO which is absent in the case of $p$-doped LaCuO and relate it to the different crystal structure. Phonon-induced electronic charge redistributions of the anomalous OBSM due to nonlocal electron-phonon interaction effects of charge-fluctuation type giving reason to dynamic stripes are also studied.
description: A discussion is added of the relation of the pseudogap and the superdonducting gap. 2 new references
Additional file 6 of From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses
Creators: name: Biao, Tang
name: Cai-feng, He
name: Xiao-hong, Lu
name: Xiao-li, Chang
name: Wen-bei, Liu
name: Jun, Wang
name: Chao, Ci
name: Tao, Yuan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 6: Figure S3. The SERPINB1 protein (a) and mRNA (b) expresison levels in CSCC cell line A431, SCL-1 and a human immortalized keratinocytes cell line Hacat were determined by Western blotting (a) and qRT–PCR (b).
,,Rasende Männer und weinende Weiber"
Creators: name: Freitag, Sabine
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 4 (1998): "1848" - Revolution & Geschlecht
Global Disk Oscillation Modes in Cataclysmic Variables and Other Newtonian Accretors
Creators: name: Ortega-Rodriguez, Manuel
name: Wagoner, Robert V.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Diskoseismology, the theoretical study of small adiabatic hydrodynamical global perturbations of geometrically thin, optically thick accretion disks around black holes (and other compact objects), is a potentially powerful probe of the gravitational field. For instance, the frequencies of the normal mode oscillations can be used to determine the elusive angular momentum parameter of the black hole. The general formalism developed by diskoseismologists for relativistic systems can be readily applied to the Newtonian case of cataclysmic variables (CVs). Some of these systems (e.g., the dwarf nova SS Cygni) show rapid oscillations in the UV with periods of tens of seconds and high coherence. In this paper, we assess the possibility that these dwarf nova oscillations (DNOs) are diskoseismic modes. Besides its importance in investigating the physical origin of DNOs, the present work could help us to answer the following question. To what extent are the similarities in the oscillation phenomenology of CVs and X-ray binaries (XRBs) indicative of a common physical mechanism?
description: 1 figure
Real-time ultrasound sensing with a mode-optimized photonic crystal slab
Creators: name: Zhu, Eric Y.
name: Charles-Herrera, Maria
name: Rewcastle, Cory
name: Gad, Raanan
name: Qian, Li
name: Levi, Ofer
Publisher: name: arXiv
Year: 2021
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Integrated photonic sensors can provide large scale, flexible detection schemes. Photonic crystal slabs (PCS) offer a miniaturized platform for wideband, sensitive ultrasound detection by exploiting the photoelastic effect in water. However, poor modal overlap with the sensing medium and non-negligible absorption loss of the aqueous medium have previously limited PCS sensor performance. In this study, we detail the development and optimization of a PCS-based acoustic sensor, by adding to it a low-loss high-index polymer cladding layer. Exploiting a mode-optimized TM-like optical resonance present in a PCS, with high bulk index sensitivity (>600 nm/RIU) and quality factor Q (>8000), we demonstrate real-time ultrasound-sensing at a noise equivalent pressure (NEP) of 170 Pa (1.9 Pa/rt Hz). The PCS sensor is backside-coupled to optical fiber which, along with its intensity-based ultrasound-sensing architecture, will allow us to scale up easily to a 2D array. This work paves the way to a sensitive compact ultrasound detector for photoacoustic-based diagnostics and monitoring of tissue.
Politische Kultur, generatives Verhalten und Verwandtschaft
Creators: name: Lipp, Carola
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 4 (1998): "1848" - Revolution & Geschlecht
The German 1848 Revolution - 150 years: The German-American Dimension
Creators: name: Freitag, Sabine
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 4 (1998): "1848" - Revolution & Geschlecht
Quantum molecular dynamics study of the pressure dependence of the ammonia inversion transition
Creators: name: Herbauts, I. M.
name: Dunstan, D. J.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The mechanism of the shift, broadening and quenching of the ammonia inversion frequency with gas pressure has been a problem of lively interest for over seventy years. A simple quantum model of the ammonia molecule perturbed by collisions with ideal gas molecules displays the essential features of the experimental data for NH3 and for ND3. The model does not display the behaviour expected from theories of quantum localisation such as quantum state diffusion and decoherence. On the other hand, models of perturbed classical oscillators do display similar behaviour to our model. The quenching of the ammonia inversion transition cannot therefore be interpreted as spatial localisation of the wavefunction.
description: pdf format, 10 pages, 4 figures
Hans Heiss u. Thomas Götz, Am Rand der Revolution. Tirol 1848/49. Wien u. Bozen: Folio, 1998.
Creators: name: Cole, Laurence
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 4 (1998): "1848" - Revolution & Geschlecht
Pierre Bourdieu et al.: Das Elend der Welt. Zeugnisse und Diagnosen alltäglichen Leidens an der Gesellschaft, Konstanz: Universitätsverlag Konstanz, 1997.
Creators: name: Mejstrik, Alexander
name: Wadauer, Sigrid
Publisher: name: Österreichische Zeitschrift für Geschichtswissenschaften
Year: 1998

description: Österreichische Zeitschrift für Geschichtswissenschaften, Bd. 9 Nr. 4 (1998): "1848" - Revolution & Geschlecht
Conception Isotropique D'Une Morphologie ParallÈle : Application à L'Usinage
Creators: name: Chablat, Damien
name: Wenger, Philippe
name: Angeles, Jorge
Publisher: name: arXiv
Year: 2007
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: The aim of this paper is the isotropic design of a hybrid morphology dedicated to 3-axis machining applications. It is necessary to ensure the feasibility of continuous, singularity-free trajectories, as well as a good manipulability in position and velocity. We want to propose an alternative design to conventional serial machine-tools. We compare a serial PPP machine-tool (three prismatic orthogonal axes) with a hybrid architecture which we optimize only the first two axes. The critrerion used for the optimization is the conditioning of the Jacobian matrices. The optimum, namely isotropy, can be obtained which provides our architecture with excellent manipulability properties.
Reinmars von Zweter ‚Idealer Mann‘ (Roethe Nr. 99 und 100)
Creators: name: Gerhardt, Christoph
Publisher: name: Trier University
Year: 2021

description: Literaturgeschichtliche Untersuchung zu einem der erfolgreichsten Gedichte des mittelhochdeutschen Spruchdichters Reinmar von Zweter (1. Hälfte des 13. Jahrhunderts), einer rätselhaften Allegorie des 'idealen Mannes', die die Forschung immer wieder irritiert hat.
คณะกรรมการตรวจสอบ การศึกษาในต่างประเทศ และความระมัดระวังทางบัญชี
Creators: name: เกรียงไกร บุญเลิศอุทัย
name: อนุวัฒน์ ภักดี
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2019
Subjects: ความระมัดระวังทางบัญชี
คุณลักษณะคณะกรรมการตรวจสอบ
การศึกษาในต่างประเทศ

description: วารสารบริหารธุรกิจ JBA, 42, 162 (เม.ย.-มิ.ย. 62), 1
Additional file 3 of From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses
Creators: name: Biao, Tang
name: Cai-feng, He
name: Xiao-hong, Lu
name: Xiao-li, Chang
name: Wen-bei, Liu
name: Jun, Wang
name: Chao, Ci
name: Tao, Yuan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Table S3. The TNC, FSCN1, SERPINB1, ACTN1, RAB31, COL3A1, COL1A1, and CD36 mRNA values in CSCC relative to healthy control in GSE32628.
title: Kant et Meinong de regula mathematica generali
title: Kant And Meinong On The Method Of Mathematics
Creators: name: Fellbaum, Aaron
Publisher: name: Universität Tübingen
Year: 2012
Subjects: subject: Erkenntnistheorie , Philosophische Semantik , Meinong, Alexius , Kant, Immanuel , Psychologismus , Semantik
subject: 100
subject: Analytische Urteile
subject: Immanuel Kant , Alexius Meinong

description: Der Autor beschäftigt sich mit einer Frühschrift von Alexius Meinong mit dem Titel: "Kants analytische Urteile und die Lehre von den Universalbegriffen". Kant wie auch Meinong besprechen synthetische und analytische Urteile. Beide bleiben dem Psychologismusvorwurf ausgesetzt und sind nur Vorläufer einer semantisch transformierten Erkenntnistheorie.
description: Hinweis: Es handelt sich hier um die zweite verbesserte Auflage (2023) der Original-Publikation aus dem Jahr 2012.
description: Originator texti cum Scripto Meinongico in iuventute "Cogitata Analytica Kantiana. Kant et doctrina conceptuum universalium" (MDCCCLXXV vel MDCCCLXXVII) tractat. Kant et Meinong sythetica cogitata et analytica cogitata introducunt. Accusatio psychologismi remanet in duos philosophos.
description: 2. Hinweis: Auf Wunsch des Autors wurden in einer separaten pdf-Datei am 25.8.2023 Corrigenda zum Werk aufgenommen.
Theory of enhanced second-harmonic generation by the quadrupole-dipole hybrid exciton
Creators: name: Roslyak, Oleksiy
name: Birman, Joseph L.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report calculated substantial enhancement of the second harmonic generation (SHG) in cuprous oxide crystals resonantly hybridized with an appropriate organic material (DCM2:CA:PS 'solid-state solvent'). The quadrupole origin of the inorganic part of the quadrupole-dipole hybrid provides inversion symmetry breaking and the organic part contributes to the oscillator strength of the hybrid. We show that the enhancement of the SHG, compared to bulk cuprous oxide crystal, is proportional to the ratio of the DCM2 dipole moment and the effective dipole moment of the quadrupole transitions in the cuprous oxide. It is also inversely proportional to the line-width of the hybrid and bulk excitons. The enhancement may be regulated by adjusting the organic blend (mutual concentration of the DCM2 and CA part of the solvent) and pumping conditions(varying the angle of incidence in case of optical pumping or populating the minimum of the lower branch of the hybrid in case of electrical pumping).
description: 8 pages, 3 figures
The underlying order induced by orthogonality and the quantum speed limit
Creators: name: Sevilla, Francisco J.
name: Valdés-Hernández, Andrea
name: Barrios, Alan J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We perform a comprehensive analysis of the set of parameters $\{r_{i}\}$ that provide the energy distribution of pure qutrits that evolve towards a distinguishable state at a finite time $τ$, when evolving under an arbitrary and time-independent Hamiltonian. The orthogonality condition is exactly solved, revealing a non-trivial interrelation between $τ$ and the energy spectrum and allowing the classification of $\{r_{i}\}$ into families organized in a 2-simplex, $δ^{2}$. Furthermore, the states determined by $\{r_{i}\}$ are likewise analyzed according to their quantum-speed limit. Namely, we construct a map that distinguishes those $r_{i}$s in $δ^{2}$ correspondent to states whose orthogonality time is limited by the Mandelstam--Tamm bound from those restricted by the Margolus--Levitin one. Our results offer a complete characterization of the physical quantities that become relevant in both the preparation and study of the dynamics of three-level states evolving towards orthogonality.
description: orthogonality time; quantum speed limit; three-level systems; dynamics towards orthogonality
Inclusion of Domain-Knowledge into GNNs using Mode-Directed Inverse Entailment
Creators: name: Dash, Tirtharaj
name: Srinivasan, Ashwin
name: Baskar, A
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences
subject: I.2.6
subject: 68T07, 68T05, 68T27, 68T30

description: We present a general technique for constructing Graph Neural Networks (GNNs) capable of using multi-relational domain knowledge. The technique is based on mode-directed inverse entailment (MDIE) developed in Inductive Logic Programming (ILP). Given a data instance $e$ and background knowledge $B$, MDIE identifies a most-specific logical formula $\bot_B(e)$ that contains all the relational information in $B$ that is related to $e$. We represent $\bot_B(e)$ by a "bottom-graph" that can be converted into a form suitable for GNN implementations. This transformation allows a principled way of incorporating generic background knowledge into GNNs: we use the term `BotGNN' for this form of graph neural networks. For several GNN variants, using real-world datasets with substantial background knowledge, we show that BotGNNs perform significantly better than both GNNs without background knowledge and a recently proposed simplified technique for including domain knowledge into GNNs. We also provide experimental evidence comparing BotGNNs favourably to multi-layer perceptrons (MLPs) that use features representing a "propositionalised" form of the background knowledge; and BotGNNs to a standard ILP based on the use of most-specific clauses. Taken together, these results point to BotGNNs as capable of combining the computational efficacy of GNNs with the representational versatility of ILP.
description: Revised version; submitted to Machine Learning Journal (MLJ)
title: Alkalinität – die unterschätzte Köchin in der „Klimaküche Ozean“
Creators: name: Eschenbach, Christiane
Publisher: name: Deutsches GeoForschungsZentrum GFZ
Year: 2020

description: Die Fähigkeit der Ozeane, atmosphärisches CO2 aufzunehmen, ist essentiell für die Klimaregulation des Erdsystems. Die sogenannte Alkalinität, als Maß für diese Aufnahmekapazität, spielt eine große Rolle in der „Klimaküche Ozean“. Sie hängt vor allem von Gehalt an Karbonaten im Meerwasser ab und ist Ergebnis der Wechselwirkungen verschiedener Komponenten des Kohlenstoff- und Nährstoffhaushalts. Die Frage ist letztlich auch, wie stark der Klimawandel das natürliche Alkalinitäts-Gleichgewicht stören kann.
Inducing a metal-insulator transition in disordered interacting Dirac fermion systems via an external magnetic field
Creators: name: Meng, Jingyao
name: Mondaini, Rubem
name: Ma, Tianxing
name: Lin, Hai-Qing
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate metal-insulator transitions on an interacting two-dimensional Dirac fermion system using the determinant quantum Monte Carlo method. The interplay between Coulomb repulsion, disorder and magnetic fields, drives the otherwise semi-metallic regime to insulating phases exhibiting different characters. In particular, with the focus on the transport mechanisms, we uncover that their combination exhibits dichotomic effects. On the one hand, the critical Zeeman field $B_c$, responsible for triggering the band-insulating phase due to spin-polarization on the carriers, is largely reduced by the presence of the electronic interaction and quenched disorder. On the other hand, the insertion of a magnetic field induces a more effective localization of the fermions, facilitating the onset of Mott or Anderson insulating phases. Yet these occur at moderate values of $B$, and cannot be explained by the full spin-polarization of the electrons.
description: Published version. 8 pages, 13 figures
Edge density of bulk states due to relativity
Creators: name: Horner, Matthew D.
name: Pachos, Jiannis K.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The boundaries of quantum materials can host a variety of exotic effects such as topologically robust edge states or anyonic quasiparticles. Here, we show that fermionic systems such as graphene that admit a low energy Dirac description can exhibit counterintuitive relativistic effects at their boundaries. As an example, we consider carbon nanotubes and demonstrate that relativistic bulk spinor states can have non zero charge density on the boundaries, in contrast to the sinusoidal distribution of non-relativistic wave functions that are necessarily zero at the boundaries. This unusual property of relativistic spinors is complementary to the linear energy dispersion relation exhibited by Dirac materials and can influence their coupling to leads, transport properties or their response to external fields.
description: 9 pages, 8 figures
Mass spectra and wave functions of $T_{QQ\bar Q\bar Q}$ tetraquarks
Creators: name: Li, Qiang
name: Chang, Chao-Hsi
name: Wang, Guo-Li
name: Wang, Tianhong
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The compact tetraquark states with fully heavy quark contents $QQ\bar Q\bar Q$ are studied as the bound states of the diquark-antidiquark within the Bethe-Salpeter framework. The (anti)diquark masses and form factors used are the same as we calculated the doubly heavy baryons in a previous work. Under the instantaneous approximation, the three-dimensional (Bethe-)Salpeter equation of the tetraquarks is derived and solved numerically to obtain the corresponding mass spectra and wave functions of the tetraquarks with $J^{PC}=0^{++}$, $1^{+-}$, and $2^{++}$. Our results show that the three ground states of $cc\bar c\bar c$ locate in the mass range of $6.4\sim6.5$GeV, and the $bb\bar b\bar b$ states in mass range of $19.2\sim19.3$GeV. The obtained relativistic wave functions naturally include the mixing effects from the possible $D$\,(or $G$) partial waves, and then can be further used to do precise calculations of the tetraquark decays. Based on the obtained results, the LHCb's observation $X(6900)$ is less likely to be the ground states of compact $cc\bar c\bar c$ tetraquarks but might be the first or second excited states. In addition, a widely used propagator-like form factor is also investigated and discussed.
description: 18 pages, 23 figures, Version updated with the PRD
Local Stellar Kinematics and Oort Constants from the LAMOST A-type Stars
Creators: name: Wang, F.
name: Zhang, H. -W.
name: Huang, Y.
name: Chen, B. -Q.
name: Wang, H. -F.
name: Wang, C.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We estimate the solar peculiar velocities and Oort constants using a sample of 5,627 A-type stars with $d<0.6\,\rm kpc$ and $|z|<0.1\,\rm kpc$, selected from the LAMOST surveys. The radial and tangential velocities of these A-type stars are fitted by using a non-axisymmetric model. The best-fitting result yields the solar peculiar velocities $(U_\odot,V_\odot,W_\odot)=(11.69\pm0.68, 10.16\pm0.51, 7.67\pm0.10)\,\rm km\,s^{-1}$ and Oort constants $A=16.31\pm0.89\,\rm km\,s^{-1}\,kpc^{-1}$, $B=-11.99\pm0.79\,\rm km\,s^{-1}\,kpc^{-1}$, $C=-3.10\pm0.48\,\rm km\,s^{-1}\,kpc^{-1}$, $K=-1.25\pm1.04\,\rm km\,s^{-1}\,kpc^{-1}$, respectively. $|K+C|>4\,\rm km\,s^{-1}\,kpc^{-1}$ means that there is a radial velocity gradient in the extended local disk, implying the local disk is in a non-asymmetric potential. Using the derived Oort constants, we derive the local angular velocity $Ω\,{\approx}\,A-B=28.30\pm1.19\,\rm km\,s^{-1}\,kpc^{-1}$. By using A-type star sample of different volumes, we further try to evaluate the impacts of the ridge pattern in $R$-$V_ϕ$ plane on constraining the solar motions and Oort constants. As the volume becomes larger toward the anti-center direction, the values of $A$ and $B$ become larger (implying a steeper slope of the local rotation curve) and the value of $V_\odot$ becomes smaller probably caused by the ridge structure and its signal increasing with distance.
description: 10 pages, 10 figures, accepted for publication in MNRAS
Role of L-Arginine on Visuospatial Abilities in Patients with Cognitive Impairment and Dementia.
Creators: name: Teotia, Sonia
name: Vani Gupta
name: Srivastava, Neena
name: Tiwari, Sunita
name: Shrikant Srivastava
name: Mohd. Kaleem Ahmad
Publisher: name: figshare
Year: 2021
Subjects: subject: 110903 Central Nervous System
subject: FOS: Clinical medicine
subject: 110999 Neurosciences not elsewhere classified

description: Contribution to KGMU Journal of Physiology 2020. ISSN 2320-2777
Zum Lesartenapparat in Edward Schröders Ausgabe von Konrads von Würzburg ‚Der Welt Lohn‘
Creators: name: Gerhardt, Christoph
Publisher: name: Trier University
Year: 2021

description: Kritische Prüfung des Lesartenapparats von Edward Schröders Edition von Konrads von Würzburg 'Der Welt Lohn' an den Handschriften.
title: Konvektive Starkwindereignisse in Deutschland
Creators: name: Mohr, Susanna
Publisher: name: Deutsches GeoForschungsZentrum GFZ
Year: 2018

description: Sturmböen im Sommer sind häufig mit schweren Schäden verbunden. Da sie in Mitteleuropa vor allem in den warmen Sommermonaten auftreten, können sie zudem bei Outdoor-Aktivitäten oder Open-Air-Veranstaltungen ein erhebliches Gefahrenpotential darstellen.
Monopole-Antimonopole Pair Production in Primordial Magnetic Fields
Creators: name: Kobayashi, Takeshi
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that monopoles can be pair produced by cosmological magnetic fields in the early universe. The pair production gives rise to relic monopoles, and at the same time induces a self-screening of the magnetic fields. By studying these effects we derive limits on the monopole mass, and also on the initial amplitude of primordial magnetic fields. Monopoles of GUT scale mass can even be produced if primordial magnetic fields exist at sufficiently high redshifts.
description: 26 pages, 3 figures, v2: minor clarification, v3: published in PRD
Additional file 2 of Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
Creators: name: Wang, Huan
name: Wang, Yiming
name: Li, Jiongyuan
name: He, Ziyi
name: Boswell, Sarah A.
name: Chung, Mirra
name: You, Fuping
name: Han, Sen
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 2: Figure S1. EC50s of response calculated based on a four-parameter log-logistic model in the ATP fold change, related to Fig. 1. Figure S2. Seahorse experiment on acute effects of TKIs on mitochondrial oxygen consumption and extracellular acidification, related to Fig. 1. Figure S3. Mitochondrial membrane potential changes in response to TKIs observed by TMRE staining and its fold change, related to Fig. 1. Figure S4. Clustering of TKI-induced transcriptome data based on tSNE analysis, related to Fig. 2. Figure S5. Cluster 0, 2, 3, 4, 6 contained over 10 significant DEGs found by log2-based fold changes, related to Fig. 2. Figure S6. Expression of genes related to tRNA aminoacylation for protein translation in different clusters or in response to different drugs, related to Fig. 2. Figure S7. Good quality and consistency of 3’DGE-UMI RNA-seq, related to Fig. 2. Figure S8. The Jackstraw plot of the top 15 principal components in the tSNE analysis, related to Fig. 2. Figure S9. The number of unique genes, total counts, and proportion of mitochondrial DNA present in the 3'DGE-UMI RNA-seq data, related to Fig. 2. Figure S10. Correlation analysis between mitochondrial DNA and total counts or between unique genes and total counts in 3’DGE-UMI RNA-seq data, related to Fig. 2. Figure S11. Comparison of differentially expressed genes detected by 3'DGE-UMI and bulk RNA-seq for sorafenib and sunitinib treatments, related to Fig. 2.
Demystifying media sources of information and levels of knowledge about COVID-19: a rapid mini-review of cross-sectional studies in Africa
Creators: name: Dickson Aruhomukama
Publisher: name: figshare
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Geography

description: This is the PRISMA checklist for the review: Demystifying media sources of information and levels of knowledge about COVID-19: a rapid mini-review of cross-sectional studies in Africa.
ทัศนคติของผู้บริโภคที่มีต่อการโฆษณาผ่านทางเครือข่ายสังคมออนไลน : กรณีศึกษา ร้านอาหารญี่ปุ่นซูชิฮิโระ
Creators: name: วรัฏฐา หวังศิริเวช
name: ภิญรดา เมธารมณ์
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2019
Subjects: การโฆษณาผ่านเครือข่าย
สังคมออนไลน์
เฟซบุ๊ก
ไลน์
อินสตาแกรม

description: วารสารบริหารธุรกิจ JBA, 42, 162 (เม.ย.-มิ.ย. 62), 27
The impact of intraclonal heterogeneity on the outcomes of Multiple Myeloma patients treated with new drugs
Creators: name: Brioli, Annamaria <1982>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/15 Malattie del sangue

description: Understanding the biology of Multiple Myeloma (MM) is of primary importance in the struggle to achieve a cure for this yet incurable neoplasm. A better knowledge of the mechanism underlying the development of MM can guide us in the development of new treatment strategies. Studies both on solid and haematological tumours have shown that cancer comprises a collection of related but subtly different clones, a feature that has been termed “intra-clonal heterogeneity”. This intra-clonal heterogeneity is likely, from a “Darwinian” natural selection perspective, to be the essential substrate for cancer evolution, disease progression and relapse. In this context the critical mechanism for tumour progression is competition between individual clones (and cancer stem cells) for the same microenvironmental “niche”, combined with the process of adaptation and natural selection. The Darwinian behavioural characteristics of cancer stem cells are applicable to MM. The knowledge that intra-clonal heterogeneity is an important feature of tumours’ biology has changed our way to addressing cancer, now considered as a composite mixture of clones and not as a linear evolving disease. In this variable therapeutic landscape it is important for clinicians and researchers to consider the impact that evolutionary biology and intra-clonal heterogeneity have on the treatment of myeloma and the emergence of treatment resistance. It is clear that if we want to effectively cure myeloma it is of primarily importance to understand disease biology and evolution. Only by doing so will we be able to effectively use all of the new tools we have at our disposal to cure myeloma and to use treatment in the most effective way possible. The aim of the present research project was to investigate at different levels the presence of intra-clonal heterogeneity in MM patients, and to evaluate the impact of treatment on clonal evolution and on patients’ outcomes.