cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae.
Creators: name: Parkinson, J
name: Bender, A
name: Nishimura, K
name: Arbogast, T
name: Mack, D
name: Toh-e, A
name: Pringle, J R
name: Dennehey, B K
name: Matsui, Y
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The Rho-type GTPase Cdc42p is required for cell polarization and bud emergence in Saccharomyces cerevisiae. To identify genes whose functions are linked to CDC42, we screened for (i) multicopy suppressors of a Ts- cdc42 mutant, (ii) mutants that require multiple copies of CDC42 for survival, and (iii) mutations that display synthetic lethality with a partial-loss-of-function allele of CDC24, which encodes a guanine nucleotide exchange factor for Cdc42p. In all three screens, we identified a new gene, BEM4. Cells from which BEM4 was deleted were inviable at 37 degrees C. These cells became unbudded, large, and round, consistent with a model in which Bem4p acts together with Cdc42p in polarity establishment and bud emergence. In some strains, the ability of CDC42 to serve as a multicopy suppressor of the Ts- growth defect of deltabem4 cells required co-overexpression of Rho1p, which is an essential Rho-type GTPase necessary for cell wall integrity. This finding suggests that Bem4p also affects Rho1p function. Bem4p displayed two-hybrid interactions with Cdc42p, Rho1p, and two of the three other known yeast Rho-type GTPases, suggesting that Bem4p can interact with multiple Rho-type GTPases. Models for the role of Bem4p include that it serves as a chaperone or modulates the interaction of these GTPases with one or more of their targets or regulators.
Local laser oxidation of titanium film for post-fabrication trimming of photonic integrated circuits
Creators: name: Tronev, Aleksandr V.
name: Parfenov, Mikhail V.
name: Bozhko, Sergey I.
name: Ionov, Andrey M.
name: Mozhchil, Rais N.
name: Chekmazov, Sergey V.
name: Agruzov, Petr M.
name: Ilichev, Igor V.
name: Shamrai, Aleksandr V.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Local laser oxidation of a thin titanium film is considered as a means of a precise adjustment of losses and effective refractive index of dielectric optical waveguides. A fine phase control of an operating point and extinction ratio enhancement up to 57 dB were demonstrated using an integrated optical Ti:LiNbO3 Mach-Zehnder modulator. This technique only slightly affects the dielectric waveguide material and is very promising for a high precision permanent trimming of photonic devices based on dielectric waveguides of different material platforms and fabrication technologies.
description: 15 pages, 10 figures, published in Optical Materials Express
Applications and Analysis of Bio-Inspired Eagle Strategy for Engineering Optimization
Creators: name: Yang, Xin-She
name: Karamanoglu, M.
name: Ting, T. O.
name: Zhao, Y. X.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: 90C26

description: All swarm-intelligence-based optimization algorithms use some stochastic components to increase the diversity of solutions during the search process. Such randomization is often represented in terms of random walks. However, it is not yet clear why some randomization techniques (and thus why some algorithms) may perform better than others for a given set of problems. In this work, we analyze these randomization methods in the context of nature-inspired algorithms. We also use eagle strategy to provide basic observations and relate step sizes and search efficiency using Markov theory. Then, we apply our analysis and observations to solve four design benchmarks, including the designs of a pressure vessel, a speed reducer, a PID controller and a heat exchanger. Our results demonstrate that eagle strategy with Lévy flights can perform extremely well in reducing the overall computational efforts.
description: 14 pages 1 figure
A Combinatorial Proof of a Schmidt Type Theorem of Andrews and Paule
Creators: name: Ji, Kathy Q.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: This note is devoted to a combinatorial proof of a Schmidt type theorem due to Andrews and Paule. A four-variable refinement of Andrews and Paule's theorem is also obtained based on this combinatorial construction.
L’accueil des familles en psychiatrie
Creators: name: Ducrettet, Elodie
name: Egger Kessler, Mireille
Publisher: name: Unknown
Year: 0
Subjects: subject: Accueil
subject: Psychiatrie
subject: Famille
subject: Relation soignant-soigné
subject: Partenariat
subject: Santé
subject: Recherche scientifique - Sciences infirmières
subject: Revue de littérature

description: Le but est d’imaginer comment l’accueil des familles en psychiatrie peut permettre la création du lien, autrement dit l’alliance thérapeutique, afin de préserver la santé de tous les membres de la famille (patient y compris). Les auteurs se demandent comment l’accueil pourrait être la première pierre ou la fondation d’une tour qui symboliserait le partenariat et qui protègerait la santé de la famille. Les résultats de recherche montrent qu’il existe réellement un malaise dans la relation famille/professionnels de santé en plusieurs points et que chacun d’eux rencontre des difficultés dans l’approche à l’autre. Les auteurs retrouvent également dans les résultats l’importance de la création d’un partenariat avec les familles dans le soin. Le postulat est le suivant : il serait nécessaire et facilitant que chacun prenne conscience des difficultés de l’autre, et collabore autour du soin afin d’assurer la continuité de celui-ci et de permettre le maintien de la santé de tous les membres de la famille.
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Creators: name: Wigler, M H
name: Westwick, J K
name: Der, C J
name: Chrzanowska-Wodnicka, M
name: Van Aelst, L
name: Solski, P A
name: Khosravi-Far, R
name: White, M A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation. For example, dominant negative mutants of Raf-1, MEK, and mitogen-activated protein kinase all inhibit Ras transformation. Furthermore, the observation that plasma membrane-localized Raf-1 exhibits the same transforming potency as oncogenic Ras suggests that Raf-1 activation alone is sufficient to mediate full Ras transforming activity. However, the recent identification of other candidate Ras effectors (e.g., RalGDS and phosphatidylinositol-3 kinase) suggests that activation of other downstream effector-mediated signaling pathways may also mediate Ras transforming activity. In support of this, two H-Ras effector domain mutants, H-Ras(12V, 37G) and H-Ras(12V, 40C), which are defective for Raf binding and activation, induced potent tumorigenic transformation of some strains of NIH 3T3 fibroblasts. These Raf-binding defective mutants of H-Ras induced a transformed morphology that was indistinguishable from that induced by activated members of Rho family proteins. Furthermore, the transforming activities of both of these mutants were synergistically enhanced by activated Raf-1 and inhibited by the dominant negative RhoA(19N) mutant, indicating that Ras may cause transformation that occurs via coordinate activation of Raf-dependent and -independent pathways that involves Rho family proteins. Finally, cotransfection of H-Ras(12V, 37G) and H-Ras(12V, 40C) resulted in synergistic cooperation of their focus-forming activities, indicating that Ras activates at least two Raf-independent, Ras effector-mediated signaling events.
The q-Log-Concavity and Unimodality of q-Kaplansky Numbers
Creators: name: Ji, Kathy Q.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: $q$-Kaplansky numbers were considered by Chen and Rota. We find that $q$-Kaplansky numbers are connected to the symmetric differences of Gaussian polynomials introduced by Reiner and Stanton. Based on the work of Reiner and Stanton, we establish the unimodality of $q$-Kaplansky numbers. We also show that $q$-Kaplansky numbers are the generating functions for the inversion number and the major index of two special kinds of $(0,1)$-sequences. Furthermore, we show that $q$-Kaplansky numbers are strongly $q$-log-concave.
Championing chronic illness management through practice based learning in primary care
Creators: name: Pickett, Mary
name: Azar, Sharen
Publisher: name: Oregon Health and Science University
Year: 2023
Subjects: subject: Curriculum
subject: Diversity, Equity, Inclusion
subject: Health sciences education
subject: Classroom/didactic teaching
subject: Clinical teaching
subject: Educational research findings
subject: Education research methods and models
subject: Skill-building

description: Population health management is an important part of comprehensive primary care. Internal Medicine resident trainees oversee care for a panel of continuity clinic patients for the duration of their three-year training program. During that time, residents must develop mastery in care of a diverse array of important chronic illnesses. This is a curriculum with vast content learning expectations, so facilitating retention of new learning is critical. Retention of new clinical learning can be solidified when didactic learning is linked to real patient and provider interactions: we identified panel-based population management as a potential keystone in our ambulatory teaching for residents.
Perception et impact de la contention physique chez le patient avec des troubles psychotiques
Creators: name: Corbaz, Maude
name: De La Baume, Katia
Publisher: name: Unknown
Year: 0
Subjects: subject: Contention
subject: Contention physique (psychiatrie)
subject: Thérapeutique
subject: Rôle infirmier
subject: Soins infirmiers en psychiatrie
subject: Recherche scientifiques - sciences infirmières
subject: Revue de littérature

description: Le but est d’explorer, lors de mesures de contention physique, les perceptions du patient avec des troubles psychotiques ainsi que l'impact thérapeutique de la contention. Ceci permet de les mettre en lien avec la contenance psychique pour questionner la pratique actuelle de la contention. Ce travail comprend le développement de plusieurs concepts tels que: - L'enveloppe psychique et la fonction contenante - L'angoisse de morcellement du patient psychotique - Les modalités thérapeutiques de la contenance psychique: le rôle du soignant - La contention - Les approches psycho-corporelles en lien avec la contention Selon les quatre concepts du méta-paradigme infirmier, le questionnement concerne la personne avec des troubles psychotiques, de 18 à 65 ans, ayant eu des expériences de contention physique en milieu psychiatrique aigu. Afin d’étayer le questionnement, des expériences personnelles, l'historique de la contention ainsi que le champ clinique de la discipline infirmière sont décrits. Ensuite la pertinence de la recherche du point de vue des contextes socio-sanitaire, éthique, légal et professionnel est expliquée. Une exploration des taux de contention en Suisse est également réalisée. La contention physique fait l’objet de grands débats et reste à nos jours controversée. Peu d'études recherchent le sens de la contention en tant que but thérapeutique. L'infirmier a un rôle important de contenance psychique du patient. Pour cela, la recherche des perceptions des patients permet de comprendre ce qu’ils vivent avant, pendant et après l'expérience de contention, à des fins d'amélioration de l'accompagnement infirmier.
p95vav associates with the nuclear protein Ku-70.
Creators: name: Fischer, S
name: Reeves, W H
name: Dargemont, C
name: Pozo, F
name: Gisselbrecht, S
name: Camonis, J
name: Romero, F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The proto-oncogene vav is expressed solely in hematopoietic cells and plays an important role in cell signaling, although little is known about the proteins involved in these pathways. To gain further information, the Src homology 2 (SH2) and 3 (SH3) domains of Vav were used to screen a lymphoid cell cDNA library by the yeast two-hybrid system. Among the positive clones, we detected a nuclear protein, Ku-70, which is the DNA-binding element of the DNA-dependent protein kinase. In Jurkat and UT7 cells, Vav is partially localized in the nuclei, as judged from immunofluorescence and confocal microscopy studies. By using glutathione S-transferase fusion proteins derived from Ku-70 and coimmunoprecipitation experiments with lysates prepared from human thymocytes and Jurkat and UT7 cells, we show that Vav associates with Ku-70. The interaction of Vav with Ku-70 requires only the 150-residue carboxy-terminal portion of Ku-70, which binds to the 25 carboxy-terminal residues of the carboxy SH3 domain of Vav. A proline-to-leucine mutation in the carboxy SH3 of Vav that blocks interaction with proline-rich sequences does not modify the binding of Ku-70, which lacks this motif. Therefore, the interaction of Vav with Ku-70 may be a novel form of protein-protein interaction. The potential role of Vav/Ku-70 complexes is discussed.
A differentiation formula, with application to the two-dimensional Schrödinger equation
Creators: name: Pikovski, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A method for obtaining discretization formulas for the derivatives of a function is presented, which relies on a generalization of divided differences. These modified divided differences essentially correspond to a change of the dependent variable. This method is applied to the numerical solution of the eigenvalue problem for the two-dimensional Schrödinger equation, where standard methods converge very slowly while the approach proposed here gives accurate results.
description: 3 pages
title: Soins auprès de personnes touchées par les symptômes comportementaux et psychiatriques de la démence
title: quelles interventions infirmières développer face aux symptômes comportementaux et psychiatriques de la démence (SCPD) afin de soutenir et d’accompagner les personnes atteintes?
titleType: Subtitle
Creators: name: Dufour-Berrocosa, Emilie
name: Cotté, Samuel
Publisher: name: Unknown
Year: 0
Subjects: subject: Démence
subject: Comportement
subject: Personne âgée
subject: Relation familiale
subject: Alzheimer (maladie)
subject: Rôle infirmier
subject: Thérapeutique
subject: Recherche scientifique - sciences infirmières
subject: Revue de littérature

description: Les symptômes comportementaux et psychiatriques de la démence (SCPD), aussi appelés behavioral and psychiatric symptoms of dementia (BPSD), se manifestent couramment chez les personnes âgées touchées par la maladie d’Alzheimer. Parmi ces symptômes, on trouve par exemple l’agitation, l’agressivité ou l’apathie. Ce travail vise à mettre en évidence des pistes d’interventions infirmières, non pharmacologiques, en vue de réduire ce phénomène car il génère un inconfort important chez les personnes touchées et leur entourage. Une revue de littérature a été effectuée. Il se dégage que les SCPD sont, d’un point de vu infirmier, l’expression de besoins. Il en ressort qu’une intervention thérapeutique s’impose afin de réduire plus rapidement les symptômes. Nous retenons également qu’il existe des thérapies non médicamenteuses qui montrent une capacité à réduire ces symptômes, notamment la narration d’histoires sélectionnées, la thérapie par le toucher, des animations adaptées au niveau de compétence et au profil de la personne, etc. Nous notons que la majorité des publications retenues sont quantitatives, ce qui démontre l’avancée de la recherche dans ce domaine. Cependant, de futurs travaux seront nécessaires afin de consolider les preuves scientifiques de leur efficacité dans le but de promouvoir leur utilisation systématique dans la pratique.
High-resolution laser-induced fluorescence spectroscopy of $^{28}$Si$^{16}$O$^+$ and $^{29}$Si$^{16}$O$^+$ in a cryogenic buffer-gas cell
Creators: name: Zhu, Guo-Zhu
name: Lao, Guanming
name: Ho, Clayton
name: Campbell, Wesley C.
name: Hudson, Eric R.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The electronic, laser-induced fluorescence spectrum of the $B^2Σ^+\leftarrow X^2Σ^+$ transition in $^{28}$Si$^{16}$O$^+$ and $^{29}$Si$^{16}$O$^+$ has been recorded in a cryogenic buffer gas cell at $\approx$ 100 K. Molecular constants are extracted for both $^{28}$Si$^{16}$O$^+$ and $^{29}$Si$^{16}$O$^+$, including the Fermi contact hyperfine constant for both the $B$ and $X$ states of $^{29}$Si$^{16}$O$^+$, and used in a discussion of the suitability of SiO$^+$ in future quantum information experiments.
description: 14 pages, 7 figures
Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
Creators: name: Fan, Q Q
name: Petes, T D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Meiotic double-strand DNA breaks (DSBs), the lesions that initiate meiotic recombination at the HIS4 recombination hot spot, occur in a region upstream of the coding sequence associated with multiple DNase I-hypersensitive sites. Mutations in transcription factors that lead to loss of the DSBs result in the loss of some but not all DNase I-hypersensitive sites in the upstream region. A meiosis-specific change in chromatin structure is detected in strains with the wild-type hot spot but not in strains with alterations that elevate or reduce hot spot activity. The position and intensity of micrococcal nuclease-hypersensitive sites correlate poorly with the sites of DSB formation.
A fractional Borel-Pompeiu type formula for holomorphic functions of two complex variables
Creators: name: González-Cervantes, José Oscar
name: Bory-Reyes, Juan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 26A33, 30G35, 32A10, 35A08, 46S05

description: The present paper is a continuation of our work [11], where we introduced a fractional operator calculus related to a fractional $ψ-$Fueter operator in the one-dimensional Riemann-Liouville derivative sense in each direction of the quaternionic structure, that depends on an additional vector of complex parameters with fractional real parts. This allowed us also to study a pair of lower order fractional operators and prove the associated analogues of both Stokes and Borel-Pompieu formulas for holomorphic functions in two complex variables.
description: arXiv admin note: substantial text overlap with arXiv:2109.09604; text overlap with arXiv:2109.10881
Comment, en tant qu’infirmière en néonatologie, préparer les parents de nouveau-nés prématurés au retour à domicile ?
Creators: name: Arnaud, Camille
name: Chuat, Laure
Publisher: name: Unknown
Year: 0
Subjects: subject: Prématuré
subject: Rôle infirmier
subject: Accompagnement
subject: Parentalité
subject: Néonatologie
subject: Nouveau-Né
subject: Relation soignant-famille
subject: Recherche scientifique - sciences infirmières
subject: Revue de littérature

description: Cette revue de littérature porte sur l’accompagnement des parents ayant eu un enfant prématuré en service de néonatologie. La naissance d’un enfant prématuré peut engendrer un stress, une désorganisation psychique et une diminution de l’interaction parent-enfant. De plus, la technologie et le matériel nécessaire à la santé ou à la survie de l’enfant sont des barrières à la place que devraient prendre les parents. Cela engendrera toutes sortes de problèmes altérant la capacité des parents à s'occuper de leur enfant de façon optimale et pouvant compromettre la qualité du retour et de la vie à domicile.
Landau theory for helical nematic phases
Creators: name: Kats, E. I.
name: Lebedev, V. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We propose Landau phenomenology for describing the phase transition from the conventional nematic into the conical helical orientationally non-uniform structure recently identified in liquid crystals formed by "banana"-shaped molecules. The mean field predictions are mostly in agreement with experimental data. Based on the analogy with de Gennes model, we argue that fluctuations of the order parameter turn the transition to the first order phase transition rather than continuous one predicted by the mean-field theory. This conclusion is in agreement with experimental observations. We discuss the new Goldstone mode to be observed in the low-temperature phase.
description: 4 pages, no figures
Topological band inversion in HgTe(001): surface and bulk signatures from photoemission
Creators: name: Vidal, Raphael C.
name: Marini, Giovanni
name: Lunczer, Lukas
name: Moser, Simon
name: Fürst, Lena
name: Jozwiak, Chris
name: Bostwick, Aaron
name: Rotenberg, Eli
name: Gould, Charles
name: Buhmann, Hartmut
name: Beugeling, Wouter
name: Sangiovanni, Giorgio
name: Di Sante, Domenico
name: Profeta, Gianni
name: Molenkamp, Laurens W.
name: Bentmann, Hendrik
name: Reinert, Friedrich
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: HgTe is a versatile topological material and has enabled the realization of a variety of topological states, including two- and three-dimensional (3D) topological insulators and topological semimetals. Nevertheless, a quantitative understanding of its electronic structure remains challenging, in particular due to coupling of the Te 5p-derived valence electrons to Hg 5d core states at shallow binding energy. We present a joint experimental and theoretical study of the electronic structure in strained HgTe(001) films in the 3D topological-insulator regime, based on angle-resolved photoelectron spectroscopy and density functional theory. The results establish detailed agreement in terms of (i) electronic band dispersions and orbital symmetries, (ii) surface and bulk contributions to the electronic structure, and (iii) the importance of Hg 5d states in the valence-band formation. Supported by theory, our experiments directly image the paradigmatic band inversion in HgTe, underlying its non-trivial band topology.
Strand specificity of mutagenic bypass replication of DNA containing psoralen monoadducts in a human cell extract.
Creators: name: Kunkel, T A
name: Svoboda, D L
name: Thomas, D C
name: Vos, J M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Psoralens are mutagenic compounds of vegetable origin that are used as photosensitizing agents in the treatment of various skin diseases, blood cell cancer, and autoimmune disorders. To study the mechanism of mutagenicity of psoralens in humans, we examined the efficiency and fidelity of simian virus 40 origin-dependent replication in a human cell extract of M13mp2 DNA randomly treated with the psoralen derivative 4'-hydroxymethyl-4,5',8-trimethyl psoralen plus UVA irradiation. Replication of DNA treated with variable amounts of 4'-hydroxymethyl-4,5',8-trimethyl psoralen and a fixed UVA fluence was inhibited in a concentration-dependent manner. However, covalently closed monomer-length circular replication products were observed. Product analysis by renaturing agarose gel electrophoresis after cross-linking with 250- to 280-nm UV light indicated that approximately 1 of 9 psoralen monoadducts was bypassed during in vitro replication. Introduction of product DNA into Escherichia coli to score replication errors in the lacZalpha reporter gene demonstrated that replication of the damaged DNA was more mutagenic than was replication of undamaged DNA. Sequence analysis of lacZ mutants revealed that damage-dependent replication errors were predominantly T.A-->C.G transitions, transversions at C.G base pairs, and deletions of single A.T base pairs, the last occurring most frequently in homopolymeric runs. A comparison of error specificities with two substrates having the replication origin asymmetrically placed on opposite sides of the mutational target suggests that the lagging-strand replication apparatus is less accurate than the leading-strand replication apparatus for psoralen monoadduct-dependent deletion errors. A model is proposed based on the preferential loopout of the monoadducted base from the strand that templates retrograde discontinuous synthesis.
title: Promouvoir l’observance au traitement antirétroviral chez la personne adulte atteinte du VIH
title: le rôle infirmier
titleType: Subtitle
Creators: name: Boillat
Publisher: name: Unknown
Year: 0
Subjects: subject: Sida
subject: Observance médicamenteuse
subject: Compliance
subject: Entretien
subject: Rôle infirmier
subject: Recherche scientifique - Sciences infirmières
subject: Revue de littérature

description: Depuis 1996, date de l’apparition des médicaments antirétroviraux (ART), l’espérance de vie des personnes atteintes du VIH a considérablement augmenté. Dès lors que l’accès aux ART est possible, les personnes touchées par le VIH doivent faire face à une maladie chronique mais aussi stigmatisante, générant de nombreux stresseurs. L’observance aux ART étant vue comme la « clé » du succès thérapeutique, les problèmes liés à cette observance représentent une problématique importante et actuelle se posant lors de la prise en soin des personnes atteintes du VIH. La mise en place d’interventions ciblées et adaptées à l’individu de la part de l’infirmière est nécessaire, ceci afin de promouvoir l’observance de la personne à ces traitements. Considéré comme un travail de référence par le Jury, ce travail a été récompensé par le Prix Source 2010.
description: Prix Source 2010
Transport Through Self-Assembled Monolayer Molecular Junctions: Role of In-Plane Dephasing
Creators: name: Dubi, Yonatan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Self-assembled-monolayer (SAM) molecular junctions (MJs) constitute a promising building block candidate for future molecular electronic devices. Transport properties of SAM-MJs are usually calculate using either the phenomenological Simmons model, or a fully-coherent transport theory, employing the SAMs periodicity. We suggest that dephasing plays an important role in determining the transport properties of SAM-MJs. We present an approach for calculating the transport properties of SAM-MJs that inherently takes into account in-plane dephasing in the electron motion as it traverses the SAM plane. The calculation is based on the non-equilibrium Green's function formalism, with a local dynamics approximation that describes incoherent motion along the SAM plane. Our approach describes well the two hallmarks of transport through SAM-MJs, namely the exponential decay of current with molecular chain length and the reduction of the current per molecule as compared to single-molecule junctions. Specifically, we show that dephasing leads to an exponential decay of the current as a function of molecular length, even for resonant tunneling, where the fully coherent calculation shows little or no length-dependence of the current. The dephasing is also shown to lead to a substantial reduction of the current in a SAM-MJ as compared to the single molecule junction, in a realistic parameter regime, where the coherent calculation shows only a very small reduction of the current. Finally, we discuss the effect of dephasing on more subtle transport phenomena such as the conductance even-odd effect and negative differential resistance.
description: 10 pages, 7 figures, accepted to J. Phys. Chem. C
A dual resolution phase-field solver for wetting of viscoelastic droplets
Creators: name: Bazesefidpar, Kazem
name: Brandt, Luca
name: Tammisola, Outi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We present a new and efficient phase-field solver for viscoelastic fluids with moving contact line based on a dual-resolution strategy. The interface between two immiscible fluids is tracked by using the Cahn-Hilliard phase-field model, and the viscoelasticity incorporated into the phase-field framework. The main challenge of this approach is to have enough resolution at the interface to approach the sharp-interface methods. The method presented here addresses this problem by solving the phase field variable on a mesh twice as fine as that used for the velocities, pressure, and polymer-stress constitutive equations. The method is based on second-order finite differences for the discretization of the fully coupled Navier-Stokes, polymeric constitutive and Cahn-Hilliard equations, and it is implemented in a 2D pencil-like domain decomposition to benefit from existing highly-scalable parallel algorithms. A FFT-based solver is used for the Helmholtz and Poisson equations with different global sizes. The splitting method proposed by previous authors is used to impose the dynamic contact angle boundary conditions in the case of large density and viscosity ratios. The implementation is validated against experimental data and previous numerical studies in 2D and 3D. The results indicate that the dual-resolution approach produces nearly identical results while saving computational time for both Newtonian and viscoelastic flows in 3D.
Prototype: Digital twin for urban overheating management in Riga, Latvia
Creators: name: Rozenvalde, Anita Līvija
Publisher: name: Zenodo
Year: 2023
Subjects: prototype
digital twin
urban overheating
planning

description: This publication is a part of the MSc Geoinformatics for Urbanised Society (University of Tartu) thesis "Exploring the applicability of the digital twin technology for mitigating urban overheating: the case of Riga, Latvia". The publication shows a prototype for a digital twin for urban overheating management for a section of the Teika neighbourhood in Riga, Latvia. This prototype was built in Unreal Engine and contains the built infrastructure, high and medium vegetation, ground surface cover of the area, as well as a dynamic Sun and temperature data. It presents a potential initial base needed for a digital twin with functionalities needed to better plan urban form in a way that reduces urban heat trapping. This publication includes two versions of the prototype - an Unreal Engine developer project (Teika_twin_project.zip) and an exported version of the prototype as a user application (Teika_twin_exe.zip).
Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells.
Creators: name: Reed, J C
name: Herman, B
name: Mahajan, N
name: Zha, H
name: Yaffe, M P
name: Fisk, H A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose-inducible cell death. Immunofluorescence studies suggested that Bax is principally associated with mitochondria in yeast cells. Removal of the carboxyl-terminal transmembrane (TM) domain from Bax [creating Bax (deltaTM)] prevented targeting to mitochondrial and completely abolished cytotoxic function in yeast cells, suggesting that membrane targeting is crucial for Bax-mediated lethality. Fusing a TM domain from Mas70p, a yeast mitochondrial outer membrane protein, to Bax (deltaTM) restored targeting to mitochondria and cytotoxic function in yeast cells. Deletion of four well-conserved amino acids (IGDE) from the BH3 domain of Bax ablated its ability to homodimerize and completely abrogated lethality in yeast cells. In contrast, several Bax mutants which retained ability to homodimerize (deltaBH1, deltaBH2, and delta1-58) also retained at least partial lethal function in yeast cells. In coimmunoprecipitation experiments, expression of the wild-type Bax protein in Rat-1 fibroblasts and 293 epithelial cells induced apoptosis, whereas the Bax (deltaIGDE) mutant failed to induce apoptosis and did not associate with endogenous wild-type Bax protein. In contrast to yeast cells, Bax (deltaTM) protein retained cytotoxic function in Rat-1 and 293 cells, was targeted largely to mitochondria, and dimerized with endogenous Bax in mammalian cells. Thus, the dimerization-mediating BH3 domain and targeting to mitochondrial membranes appear to be essential for the cytotoxic function of Bax in both yeast and mammalian cells.
Direct determination of spin orbit interaction coefficients and realization of the persistent spin helix symmetry
Creators: name: Sasaki, A.
name: Nonaka, S.
name: Kunihashi, Y.
name: Kohda, M.
name: Bauernfeind, T.
name: Dollinger, T.
name: Richter, K.
name: Nitta, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The spin orbit interaction plays a crucial role in diverse fields of condensed matter, including the investigation of Majorana fermions, topological insulators, quantum information and spintronics. In III V zinc blende semiconductor heterostructures, two types of spin orbit interaction, Rashba and Dresselhaus act on the electron spin as effective magnetic fields with different directions. They are characterized by coefficients alpha and beta, respectively. When alpha is equal to beta, the so called persistent spin helix symmetry is realized. In this condition, invariance with respect to spin rotations is achieved even in the presence of the spin orbit interaction, implying strongly enhanced spin lifetimes for spatially periodic spin modes. Existing methods to evaluate alpha/beta require fitting analyses that often include ambiguity in the parameters used. Here, we experimentally demonstrate a simple and fitting parameter free technique to determine alpha/beta and to deduce the absolute values of alpha and beta. The method is based on the detection of the effective magnetic field direction and the strength induced by the two spin orbit interactions. Moreover, we observe the persistent spin helix symmetry by gate tuning.
description: 34 pages with 7 figures including supplementary information. appears in Nature Nanotechnology (2014) Published online 13 July 2014
Some characterizations of slice regular Lipschitz type spaces
Creators: name: González-Cervantes, José Oscar
name: González-Campos, Daniel
name: Bory-Reyes, Juan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Functional Analysis (math.FA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30G30, 30G35, 35R11, 51F30

description: We give some characterizations of Lipschitz type spaces of slice regular functions in the unit ball of the skew field of quaternions with prescribed modulus of continuity.
Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.
Creators: name: Morham, S G
name: Smithies, O
name: Voulomanos, N
name: Kluckman, K D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Topoisomerase I has ubiquitous roles in important cellular functions such as replication, transcription, and recombination. In order to further characterize this enzyme in vivo, we have used gene targeting to inactivate the mouse Top-1 gene. A selection protocol using the topoisomerase I inhibitor camptothecin facilitated isolation of embryonic stem cell clones containing an inactivated allele; isolation of correctly targeted clones was enhanced 75-fold over that achieved by normal selection procedures. The disrupted Top-1 allele is embryonic lethal when homozygous, and development of such embryos fails between the 4- and 16-cell stages. Both sperm and oocytes containing the inactive allele maintain viability through the fertilization point, and thus gene expression of topoisomerase I is not required for gamete viability. These studies demonstrate that topoisomerase I is essential for cell growth and division in vivo. The Top-1 gene was also shown to be linked to the agouti locus.
title: Soutien infirmier à la fratrie de l’enfant atteint du cancer
title: « quel type de soutien l’infirmière peut-elle offrir à la fratrie en âge scolaire d’un enfant hospitalisé dans un service d’oncologie ? »
titleType: Subtitle
Creators: name: Badel, Floriane
name: Girardet, Géraldine
Publisher: name: Unknown
Year: 0
Subjects: subject: Cancer
subject: Enfant
subject: Relation familiale
subject: Relations frères-soeurs
subject: Rôle infirmier
subject: Accompagnement
subject: Besoins de patient
subject: Recherche scientifique - Sciences infirmières
subject: Revue de littérature

description: Pour répondre à la question posée, une revue littéraire a été élaborée. Les articles, parus entre 2000 et 2010, ont été recherchés sur les bases de données Medline et Cinhal essentiellement. Les principaux mots clés utilisés sont les suivants : social support, siblings, cancer, childhood cancer, coping et nursing care. De ces articles ressortent les consensus suivants : la fratrie de l’enfant malade du cancer souffre indéniablement de cette situation. Elle peut développer des problématiques comportementales et émotionnelles. Des recherches ont démontré les bénéfices et les différentes dimensions du soutien social envers la fratrie, ainsi que l’intérêt de l’implication infirmière qui se trouve en première ligne pour détecter les problématiques. Les recommandations pour l’infirmière concernent des interventions envers les parents et la fratrie. L’infirmière, avec des connaissances acquises sur le sujet, peut sensibiliser les parents face au vécu de leur(s) enfant(s) sain(s) et aux éventuels problèmes comportementaux et émotionnels qu’ils peuvent développer. Les recherches dans le temps ont beaucoup évolué, en se focalisant davantage sur l’expérimentation de la maladie et le ressenti du besoin de soutien social chez la fratrie et non plus sur le ressenti des parents qui diffère essentiellement de leur(s) enfant(s) sain(s). Cette remarque montre l’intérêt pour l’infirmière d’établir une relation d’écoute avec la fratrie, afin que cette dernière puisse exprimer ses besoins et le(s) type(s) de soutien social qui lui seraient nécessaire afin de s’adapter à cette expérience de vie. Une des perspectives d’avenir pour la pratique infirmière serait la création et l’utilisation d’un questionnaire destiné à la fratrie, dans le but d’évaluer au mieux ses besoins.
Momentum space imaging of Cooper pairing in a half-Dirac-gas topological superconductor (a helical 2D topological superconductor)
Creators: name: Xu, Su-Yang
name: Alidoust, Nasser
name: Belopolski, Ilya
name: Richardella, Anthony
name: Liu, Chang
name: Neupane, Madhab
name: Bian, Guang
name: Huang, Song-Hsun
name: Sankar, Raman
name: Fang, Chen
name: Dellabetta, Brian
name: Dai, Wenqing
name: Li, Qi
name: Gilbert, Matthew J.
name: Chou, Fangcheng
name: Samarth, Nitin
name: Hasan, M. Zahid
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Superconductivity in Dirac electrons has recently been proposed as a new platform between novel concepts in high-energy and condensed matter physics. It has been proposed that supersymmetry and exotic quasiparticles, both of which remain elusive in particle physics, may be realized as emergent particles in superconducting Dirac electron systems. Using artificially fabricated topological insulator-superconductor heterostructures, we present direct spectroscopic evidence for the existence of Cooper pairing in a half Dirac gas 2D topological superconductor. Our studies reveal that superconductivity in a helical Dirac gas is distinctly different from that of in an ordinary two-dimensional superconductor while considering the spin degrees of freedom of electrons. We further show that the pairing of Dirac electrons can be suppressed by time-reversal symmetry breaking impurities removing the distinction. Our demonstration and momentum-space imaging of Cooper pairing in a half Dirac gas and its magnetic behavior taken together serve as a critically important 2D topological superconductor platform for future testing of novel fundamental physics predictions such as emergent supersymmetry and quantum criticality in topological systems.
description: Submitted June'14; Accepted to NaturePhysics, to appear AOP (2014)
Quelles stratégies la littérature infirmière fournit-elle concernant la gestion des émotions chez les infirmières ?
Creators: name: Tzaut, Ophélie
name: Volet, Ariane
Publisher: name: Unknown
Year: 0
Subjects: subject: infirmier / infirmière
subject: pratique professionnelle
subject: émotions
subject: qualité des soins
subject: santé au travail

description: Le jury a particulièrement relevé la qualité d'analyse des articles et l'actualité du sujet.
Mechanical response of a thick poroelastic gel in contactless colloidal-probe rheology
Creators: name: Kopecz-Muller, Caroline
name: Bertin, Vincent
name: Raphael, Elie
name: Mcgraw, Joshua D
name: Salez, Thomas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: When a rigid object approaches a soft material in a viscous fluid, hydrodynamic stresses arise in the lubricated contact region and deform the soft material. The elastic deformation modifies in turn the flow, hence generating a soft-lubrication coupling. Moreover, soft elastomers and gels are often porous. These materials may be filled with solvent or uncrosslinked polymer chains, and might be permeable to the surrounding fluid, which complexifies further the description. Here, we derive the point-force response of a semi-infinite and permeable poroelastic substrate. Then, we use this fundamental solution in order to address the specific poroelastic lubrication coupling associated with contactless colloidal-probe methods. In particular, we derive the conservative and dissipative components of the force associated with the oscillating vertical motion of a sphere close to the poroelastic substrate. Our results may be relevant for dynamic surface force apparatus and contactless colloidal-probe atomic force microscopy experiments on soft, living and/or fragile materials, such as swollen hydrogels and biological membranes.
TC21 causes transformation by Raf-independent signaling pathways.
Creators: name: Der, C J
name: Graham, S M
name: Vojtek, A B
name: Cooper, J A
name: Cox, A D
name: Huff, S Y
name: Clark, G J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Although the Ras-related protein TC21/R-Ras2 has only 55% amino acid identity with Ras proteins, mutated forms of TC21 exhibit the same potent transforming activity as constitutively activated forms of Ras. Therefore, like Ras, TC21 may activate signaling pathways that control normal cell growth and differentiation. To address this possibility, we determined if regulators and effectors of Ras are also important for controlling TC21 activity. First, we determined that Ras guanine nucleotide exchange factors (SOS1 and RasGRF/CDC25) synergistically enhanced wild-type TC21 activity in vivo and that Ras GTPase-activating proteins (GAPs; p120-GAP and NF1-GAP) stimulated wild-type TC21 GTP hydrolysis in vitro. Thus, extracellular signals that activate Ras via SOS1 activation may cause coordinate activation of Ras and TC21. Second, we determined if Raf kinases were effectors for TC21 transformation. Unexpectedly, yeast two-hybrid binding analyses showed that although both Ras and TC21 could interact with the isolated Ras-binding domain of Raf-1, only Ras interacted with full-length Raf-1, A-Raf, or B-Raf. Consistent with this observation, we found that Ras- but not TC21-transformed NIH 3T3 cells possessed constitutively elevated Raf-1 and B-Raf kinase activity. Thus, Raf kinases are effectors for Ras, but not TC21, signaling and transformation. We conclude that common upstream signals cause activation of Ras and TC21, but activated TC21 controls cell growth via distinct Raf-independent downstream signaling pathways.
Effective and Trustworthy Dimensionality Reduction Approaches for High Dimensional Data Understanding and Visualization
Creators: name: Hajderanj, Laureta
Publisher: name: London South Bank University
Year: 2022

description: In recent years, the huge expansion of digital technologies has vastly increased the volume of data to be explored. Reducing the dimensionality of data is an essential step in data exploration and visualisation. The integrity of a dimensionality reduction technique relates to the goodness of maintaining the data structure. The visualisation of a low dimensional data that has not captured the high dimensional space data structure is untrustworthy. The scale of maintained data structure by a method depends on several factors, such as the type of data considered and tuning parameters. The type of the data includes linear and nonlinear data, and the tuning parameters include the number of neighbours and perplexity. In reality, most of the data under consideration are nonlinear, and the process to tune parameters could be costly since it depends on the number of data samples considered. Currently, the existing dimensionality reduction approaches suffer from the following problems: 1) Only work well with linear data, 2) The scale of maintained data structure is related to the number of data samples considered, and/or 3) Tear problem and false neighbours problem.To deal with all the above-mentioned problems, this research has developed Same Degree Distribution (SDD), multi-SDD (MSDD) and parameter-free SDD approaches , that 1) Saves computational time because its tuning parameter does not 2) Produces more trustworthy visualisation by using degree-distribution that is smooth enough to capture local and global data structure, and 3) Does not suffer from tear and false neighbours problems due to using the same degree-distribution in the high and low dimensional spaces to calculate the similarities between data samples. The developed dimensionality reduction methods are tested with several popu- lar synthetics and real datasets. The scale of the maintained data structure is evaluated using different quality metrics, i.e., Kendall’s Tau coefficient, Trustworthiness, Continuity, LCMC, and Co-ranking matrix. Also, the theoretical analysis of the impact of dissimilarity measure in structure capturing has been supported by simulations results conducted in two different datasets evaluated by Kendall’s Tau and Co-ranking matrix. The SDD, MSDD, and parameter-free SDD methods do not outperform other global methods such as Isomap in data with a large fraction of large pairwise distances, and it remains a further work task. Reducing the computational complexity is another objective for further work.