cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of phosphorylation and limited proteolytic cleavage of talin and vinculin in the disruption of focal adhesion integrity
Creators: name: BURRIDGE, K
name: PAVALHO, F.
name: TURNER, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: Chemical agents which activate specific kinases were employed to disrupt the stress fiber and focal adhesion organization of cells spread on a substratum. The phorbol ester 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C, promoted a rapid loss of stress fibers and focal adhesions from African green monkey kidney (BSC-1) cells. This was paralleled by an increase in the level of talin phosphorylation suggesting that this may play a role in the removal of talin from focal adhesions. Similar morphological changes were produced in the rat embryo fibroblast line (REF 52) by dibutyryl-cAMP, which stimulates protein kinase A. In contrast, however, the phosphorylation of talin was reduced in REF 52 cells when treated with dibutyryl cAMP. In untreated cells we found that the levels of vinculin phosphorylation were very low relative to the levels of talin phosphorylation and did not change following drug treatment in either cell line. Although limited proteolytic cleavage of cytoskeletal proteins represents a potential mechanism for focal adhesion disruption, we observed no proteolysis of talin or vinculin in response to either drug treatment.
Tensor polarization of vector mesons from quark and gluon fragmentation
Creators: name: Schaefer, A.
name: Szymanowski, L.
name: Teryaev, O. V.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We considered the electro- and photoproduction of ρand other vector mesons with moderately large transverse momentum in the scattering of unpolarized electrons on unpolarized nucleons and nuclei. For these processes we have analyzed how to extract the novel fragmentation functions \bar b_1^q(z), \bar b_1^G(z), describing tensor polarization, and the photon double spin-flip distribution Δ^γfrom the angular distribution of meson decay products.
description: 9 pages, LATEX with 2 .eps figures
Chirp assisted ion acceleration via relativistic self induced transparency
Creators: name: Choudhary, Shivani
name: Holkundkar, Amol R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We study the effect of the chirped laser pulse on the transmission and associated ion acceleration by the sub-wavelength target. In the chirped laser pulses, the pulse frequency has a temporal variation about its fundamental frequency, which manifests to the temporal dependence of the critical density ($n_c$). In this work we used a chirp model which is beyond the linear approximation. For negatively (positively) chirped pulses, the high (low) frequency component of the pulse interacts with the target initially followed by the low (high) frequency component. The threshold plasma density for the transmission of the pulse is found to be higher for the negatively chirped laser pulses as compared to the unchirped or positively chirped pulses. The enhanced transmission of the negatively chirped pulses for higher densities ($6n_c$) results in very efficient heating of the target electrons, creating a very stable and persistent longitudinal electrostatic field behind the target. The void of the electrons results in expansion of the target ions in either direction, resulting in the broad energy spectrum. We have introduced a very thin, low density ($< n_c$) secondary layer behind the primary layer. The ions from the secondary layer are then found to be accelerated as a mono-energetic bunch under the influence of the electrostatic field created by the primary layer upon interaction by the negatively chirped pulse. Under the optimum conditions, the maximum energy of the protons are found to be $\sim 100$ MeV for 10 fs (intensity fwhm); Circularly Polarized; Gaussian; negatively chirped laser pulse with peak intensity $\sim 8.5\times 10^{20}$ W/cm$^2$.
description: 9 pages, 10 figures
Analytical forms of the deuteron wave function for Nijmegen group potentials and polarization characteristics of A(d,d')X reactions
Creators: name: Zhaba, V. I.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Polarization observables of the A(d,d')X reactions have been calculated according to the received coeffcients of the analytical form for deuteron wave function in coordinate space for the nucleon-nucleon Nijmegen group potentials (NijmI, NijmII, Nijm93). The obtained values of tensor Ayy and vector Ay analyzing powers have been compared with the published experimental data at t- scaling for the inelastic scattering of deuterons on hydrogen, carbon and beryllium. Theoretical values of tensor-tensor Kyy and vector-vector Ky polarization transfers have been also evaluated in the plane-wave impulse approximation.
description: 14 pages, 7 figures
Additional file 1: of The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line
Creators: name: Monnier, Annabelle
name: Boniface, Rachel
name: RĂŠgis Bouvet
name: Etcheverry, Amandine
name: Aubry, Marc
name: Avril, Tony
name: VĂŠronique Quillien
name: Chevet, Eric
name: Mosser, Jean
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: (DOCX 318 kb)
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties.
Creators: name: Downes, CP
name: Waldo, Gary L
name: Harden, TK
name: Morris, Andrew J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Eighty-three percent of polyphosphoinositide-specific phospholipase C activity was recovered in a cytosolic fraction after nitrogen cavitation of turkey erythrocytes. This activity has been purified approximately 50,000-fold when compared to the starting cytosol with a yield of 1.7-5.0%. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the phospholipase C preparation revealed a major polypeptide of 150 kDa. The specific activity of the purified enzyme was 6.7-14.0 mumol/min/mg of protein with phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 4-phosphate as substrate. Phospholipase C activity was markedly dependent on the presence of Ca2+. The phospholipase C showed an acidic pH optimum (pH 4.0). At neutral pH, noncyclic inositol phosphates were the major products formed by the phospholipase C, while at pH 4.0, substantial formation of inositol 1:2-cyclic phosphate derivatives occurred. Properties of the purified 150-kDa turkey erythrocyte phospholipase C were compared with the approximately 150-kDa phospholipase C-beta and -gamma isoenzymes previously purified from bovine brain (Ryu, S. H., Cho, K. S., Lee, K. Y., Suh, P. G., and Rhee, S. G. (1987) J. Biol. Chem. 262, 12511-12518). The turkey erythrocyte phospholipase C differed from the two mammalian phospholipases with respect to the effect of sodium cholate on the rate of polyphosphoinositide hydrolysis observed. Moreover, when presented with dispersions of pure inositol lipids, phospholipases C-beta and -gamma displayed comparable maximal rates of polyphosphoinositide and phosphatidylinositol hydrolysis. By contrast, the turkey erythrocyte phospholipase C displays a marked preference for polyphosphoinositide substrates.
Thermoelectric characterization of the Kondo resonance in nanowire quantum dots
Creators: name: Svilans, Artis
name: Josefsson, Martin
name: Burke, Adam M.
name: Fahlvik, Sofia
name: Thelander, Claes
name: Linke, Heiner
name: Leijnse, Martin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We experimentally verify hitherto untested theoretical predictions about the thermoelectric properties of Kondo correlated quantum dots (QDs). The specific conditions required for this study are obtained by using QDs epitaxially grown in nanowires, combined with a recently developed method for controlling and measuring temperature differences at the nanoscale. This makes it possible to obtain data of very high quality both below and above the Kondo temperature, and allows a quantitative comparison with theoretical predictions. Specifically, we verify that Kondo correlations can induce a polarity change of the thermoelectric current, which can be reversed either by increasing the temperature or by applying a magnetic field.
Nambu-Jona-Lasinio Model at the Next-to-Leading Order in 1/N
Creators: name: Akama, Keiichi
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We derived and solved the compositeness condition in the Nambu-Jona-Lasinio model at the next-to-leading order in 1/N, and obtained the expressions for the effective coupling constants in terms of the compositeness scale. In the NJL model with a scalar composite, the next to leading contributions are too large for N=3. In the induced gauge theory with abelian gauge symmetry, the correction term is reasonably suppressed, while, in the SU(N_c) gauge theory with N_f flavors of fermions, the correction is suppressed only for N_f>11N_c/2, complementarily to asymptotic freedom.
description: 7 pages, latex, Invited talk presented at International Conference on Quark Lepton Nuclear Physics, Osaka, Japan, May 1997. To be published in Proceedings
Why do protoplanetary disks appear not massive enough to form the known exoplanet population?
Creators: name: Manara, C. F.
name: Morbidelli, A.
name: Guillot, T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: When and how planets form in protoplanetary disks is still a topic of discussion. Exoplanet detection surveys and protoplanetary disk surveys are now providing results that allow us to have new insights. We collect the masses of confirmed exoplanets and compare their dependence with stellar mass with the same dependence for protoplanetary disk masses measured in ~1-3 Myr old star-forming regions. The latter are recalculated by us using the new estimates of their distances derived from Gaia DR2 parallaxes. We note that single and multiple exoplanetary systems form two different populations, probably pointing to a different formation mechanism for massive giant planets around very low mass stars. While expecting that the mass in exoplanetary systems is much lower than the measured disk masses, we instead find that exoplanetary systems masses are comparable or higher than the most massive disks. This same result is found also by converting the measured planet masses into heavy-element content (core masses for the giant planets and full masses for the super-Earth systems) and by comparing this value with the disk dust masses. Unless disk dust masses are heavily underestimated, this is a big conundrum. An extremely efficient recycling of dust particles in the disk cannot solve this conundrum. This implies that either the cores of planets have formed very rapidly (<0.1-1 Myr) and large amount of gas is expelled on the same timescales from the disk, or that disks are continuously replenished of fresh planet-forming material from the environment. These hypotheses can be tested by measuring disk masses in even younger targets and by better understanding if and how the disks are replenished by their surroundings.
description: Accepted to A&A Letter, language edited version
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts.
Creators: name: Morris, Andrew J
name: Waldo, Gary L
name: Downes, CP
name: Harden, TK
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The preceding paper describes purification and properties of a 150-kDa polyphosphoinositide-specific phospholipase C from a cytosolic fraction of turkey erythrocytes (Morris, A. J., Waldo, G. L., Downes, C. P., and Harden, T. K. (1990) J. Biol. Chem. 265, 13501-13507). Turkey erythrocytes express a P2Y-purinergic receptor that employs an unidentified G-protein to activate phospholipase C (Boyer, J. L., Downes, C. P., and Harden, T. K. (1989) J. Biol. Chem. 264, 884-890; Cooper, C. L., Morris, A. J., and Harden, T. K. (1989) J. Biol. Chem. 264, 6202-6206). This paper describes receptor and G-protein regulation of the purified turkey erythrocyte phospholipase C after reconstitution of the enzyme using [3H]inositol pre-labeled turkey erythrocyte ghosts as acceptor membranes. These membranes contain polyphosphoinositides labeled to high specific radioactivity and display reduced responsiveness of their endogenous phospholipase C to P2Y-purinergic receptor agonists and guanine nucleotides. Reconstitution of purified enzyme had no effect on basal inositol phosphate production, but markedly increased P2Y-purinergic receptor agonist and guanine nucleotide-dependent accumulation of inositol phosphates. Reconstitution of 5 ng of purified phospholipase C with 10 micrograms of acceptor membrane protein produced half-maximal effects, and maximal activity was observed with reconstitution of 100 ng of purified enzyme. Agonist and guanine nucleotide-regulated phospholipase C activity measured using a reconstitution assay co-purified with phospholipase C activity detected using exogenously provided phosphatidylinositol 4,5-bisphosphate during purification of the 150-kDa protein. Only the maximal rate of inositol phosphate formation attained upon activation was increased in the presence of the purified phospholipase C. K0.5 values for adenosine 5'-O-(2-thiodiphosphate), guanosine 5'-3-O-(thio)triphosphate, and A1F4- activation of the purified enzyme were the same as for the endogenous phospholipase C activity of the acceptor membranes.
Electron - Proton Scattering as a Probe of Nucleon Structure
Creators: name: Hussein, M. T.
name: Elmualed, R.
name: Hassan, N. M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The problem of electron-proton scattering is handed over both the elastic and inelastic scattering. Two models are presented in this sense. The first, depends on the multi photon exchange ladder diagram, where the transition matrix is expanded in multi steps form. The second model uses the multi peripheral mechanism developed for the electromagnetic field. It allows the particle production in the inelastic scattering processes. An iterative procedure is found and inserted in a Monte Carlo program to reproduce the differential cross section of the reaction. The comparison with the experimental data shows bid fair in most cases.
description: 6 pages (revtex), 8 figures/gif
The Isotope Effect in d-Wave Superconductors
Creators: name: Schüttler, H. -B.
name: Pao, C. -H.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: Based on recently proposed anti-ferromagnetic spin fluctuation exchange models for $d_{x^2-y^2}$-superconductors, we show that coupling to harmonic phonons {\it{cannot}} account for the observed isotope effect in the cuprate high-$T_c$ materials, whereas coupling to strongly anharmonic multiple-well lattice tunneling modes {\it{can}}. Our results thus point towards a strongly enhanced {\it{effective}} electron-phonon coupling and a possible break-down of Migdal-Eliashberg theory in the cuprates.
description: 12 pages + 2 figures, Postscript files, all uuencoded Phys. Rev. Lett. (1995, to be published)
A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis.
Creators: name: Kennedy, CH
name: Mason, RP
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Radical production from 3,5-bis(ethoxycarbonyl)-4-ethyl-2,6-dimethyl-1,4- dihydropyridine (DDEP) in rat liver microsomes has been attributed to one-electron oxidation via cytochrome P-450 followed by extrusion of an ethyl radical. In the presence of the spin trap alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone (4-POBN), this radical was detected as the 4-POBN/ethyl radical adduct by electron paramagnetic resonance spectroscopy. The addition of catalase resulted in over a 50% decrease in radical production. The concentration of the 4-POBN/ethyl radical adduct increased about 9-fold in the presence of EDTA and approximately 2-fold in the presence of either diethylenetriaminepentaacetic acid (DTPA) or deferoxamine mesylate. When DDEP was incubated with deferoxamine mesylate-washed microsomes and NADPH in Chelex-treated incubation buffer, much less 4-POBN/ethyl radical formation occurred. Addition of either DTPA, EDTA, or the ferric complexes of these chelators greatly stimulated production of the 4-POBN/ethyl radical adduct in this system. These results suggest that the ethyl radicals produced from DDEP in a microsomal system arise via trace transition metal-catalyzed reactions.
Beam test results of 3D fine-grained scintillator detector prototype for a T2K ND280 neutrino active target
Creators: name: Mineev, O.
name: Blondel, A.
name: Favre, Y.
name: Fedotov, S.
name: Khotjantsev, A.
name: Korzenev, A.
name: Kudenko, Yu.
name: Mefodiev, A.
name: Noah, E.
name: Sgalaberna, D.
name: Suvorov, S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: An upgrade of the long baseline neutrino experiment T2K near detector ND280 is currently being developed with the goal to reduce systematic uncertainties in the prediction of number of events at the far detector Super-Kamiokande. The upgrade program includes the design and construction of a new highly granular fully active scintillator detector with 3D WLS fiber readout as a neutrino target. The detector of about $200\times 180\times 60~cm^3$ in size and a mass of $\sim$2.2~tons will be assembled from about $2\times10^6$ plastic scintillator cubes of $1\times1\times1~cm^3$. Each cube is read out by three orthogonal Kuraray Y11 Wave Length Shifting (WLS) fibers threaded through the detector. A detector prototype made of 125 cubes was assembled and tested in a charged particle test beam at CERN in the fall of 2017. This paper presents the results obtained on the light yield and timing as well as on the optical cross-talk between the cubes.
description: 5 pages, 8 figures
Gauge-invariant Green's functions for the bosonic sector of the standard model
Creators: name: Nyffeler, Andreas
name: Schenk, Andreas
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: There are many applications in gauge theories where the usually employed framework involving gauge-dependent Green's functions leads to considerable problems. In order to overcome the difficulties invariably tied to gauge dependence, we present a manifestly gauge-invariant approach. We propose a generating functional of appropriately chosen gauge-invariant Green's functions for the bosonic sector of the standard model. Since the corresponding external sources emit one-particle states, these functions yield the same S-matrix elements as those obtained in the usual framework. We evaluate the generating functional for the bosonic sector of the standard model up to the one-loop level and carry out its renormalization in the on-shell scheme. Explicit results for some two-point functions are given. Gauge invariance is manifest at any step of our calculation.
description: 29 pages, Revtex. v2: Discussions improved, conclusions unchanged. Some references added. v3: Published version
Pheidole senex Gregg
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole senex

description: Pheidole senex Gregg
Pheidole senex Gregg 1952a: 1. Syn.: Pheidole pilifera subsp. anfracta Cole 1952c: 278, synonymy by Cole 1953g: 298.
Types Mus. Comp. Zool. Harvard.
Etymology L senex, old, senior, possibly alluding to rugulose sculpture of head and mesosoma.
diagnosis A member of the " pilifera complex" of the larger pilifera group, comprising calens, californica, carrolli, cavigenis, clementensis, creightoni, hoplitica, littoralis, micula, pilifera, polymorpha, rugulosa, senex, soritis, tepicana, and torosa, which complex is distinguished by the following traits. Major: dorsal head surface extensively sculptured; occipital lobes transversely rugulose (or, in carrolli smooth, in littoralis foveate, and in micula and soritis carinulate), postpetiole from above diamond-shaped, trapezoidal, or spinose. Minor: eye medium-sized to large.
P. senex is distinguished within the complex by the following combination of traits.
Major: large; mesonotal convexity subangulate in dorsal-oblique view, and descends steeply to metathorax in side view; petiolar node tapers to a point in side view; postpetiole from above spinose; sides of pronotum, mesonotum, and propodeum, longitudinally carinulate; anterior dorsal profde of head flat; cephalic pilosity short and erect.
Minor: entire dorsal surface of head except mid-section of clypeus longitudinally carinulate; all of mesosoma foveolate and opaque. Measurements (mm) Paratype major: HW 1.74, HL 1.86, SL 0.78, EL 0.22, PW 0.82. Paratype minor: HW 0.64, HL 0.66, SL 0.68, EL 0.14, PW 0.40. color Major and minor: light yellowish to reddish brown.
range West-central Arizona through New Mexico to the Texas Panhandle and southern Colorado; apparently rare.
Biology Gregg (1963) reports P. senex from Campo, Colorado, in short grass prairie nesting in clay under rocks at 1300 m. Cole recorded it in New Mexico from 2000 to 2700 m. At Springerville, Arizona, I found a colony under a rock in grassy desert. In the Texas Panhandle, Moody and Francke (1982) found two colonies, one beneath a stone and the other in open soil.
Figure Upper: paratype, major. Lower: paratype, minor. COLORADO: 14 km south of Campo, Baca Co., extreme southeastern Colorado (Robert E. Gregg). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 596
Radiation of a Charge Exiting Open-Ended Waveguide with Dielectric Filling
Creators: name: Galyamin, Sergey N.
name: Tyukhtin, Andrey V.
name: Vorobev, Viktor V.
name: Grigoreva, Alexandra A.
name: Aryshev, Alexander S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We consider a semi-infinite open-ended cylindrical waveguide with uniform dielectric filling placed into collinear infinite vacuum waveguide with larger radius. Electromagnetic field produced by a point charge or Gaussian bunch moving along structure's axis from the dielectric waveguide into the vacuum one is investigated. We utilize the modified residue-calculus technique and obtain rigorous analytical solution of the problem by determining coefficients of mode excitation in each subarea of the structure. Numerical simulations in CST Particle Studio are also performed and an excellent agreement between analytical and simulated results is shown. The main attention is paid to analysis of Cherenkov radiation generated in the inner dielectric waveguide and penetrated into vacuum regions of the outer waveguide. The discussed structure can be used for generation of Terahertz radiation by modulated bunches (bunch trains) by means of high-order Cherenkov modes. In this case, numerical simulations becomes difficult while the developed analytical technique allows for efficient calculation of the radiation characteristics.
description: 13 pages, 11 figures
The $λΛ$ interaction and the reaction $Ξ^- + d \to n + Λ+ Λ$
Creators: name: Carr, S. B.
name: Afnan, I. R.
name: Gibson, B. F.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The $ΛΛ$ interaction resulting from the SU(3) rotation of the S-wave component of the Nijmegen OBE potential $D$ is used to calculate the binding energy of $^{ 6}_{ΛΛ}$He as a $ΛΛα$ three-body system, and the neutron differential energy spectrum for the reaction $Ξ^- + d \to n + Λ+ Λ$.
description: 5 pages and 9 eps files
A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.
Creators: name: Wilson, E M
name: Olsen, K L
name: Sar, M
name: Simental, J A
name: French, F S
name: Yarbrough, W G
name: Quarmby, V E
name: Joseph, D R
name: Lubahn, D B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The complete form of androgen insensitivity is an inherited X-linked syndrome in which genetic males fail to undergo masculinization in utero due to defective functioning of the androgen receptor (AR). The molecular basis of androgen insensitivity was investigated in the testicular feminized (Tfm) rat with this syndrome. AR mRNA size and amount, as well as nuclear AR protein revealed by immunocytochemistry, suggested normal expression of the AR gene in the Tfm rat. Sequence analysis of the AR coding region from Tfm and wild-type littermate male rats revealed a single transition mutation, guanine to adenine, within exon E, changing arginine 734 to glutamine within the steroid-binding domain of the AR. This arginine is highly conserved among the family of nuclear receptors and may be part of a phosphorylation recognition site. A recreated mutant AR (Arg734----Gln) expressed in COS cells had only 10-15% of the androgen-binding capacity of wild-type AR; the reduced androgen-binding capacity was similar to that of AR in tissue extracts of the Tfm rat. Stimulation of transcriptional activity by the recreated mutant AR was reduced relative to wild-type AR in cotransfection assays in CV1 cells using as reporter plasmid the mouse mammary tumor virus promoter linked to the chloramphenicol acetyltransferase gene. Thus, arginine 734 appears essential for normal AR function both in androgen binding and transcriptional activation. Absence of these functions results in androgen insensitivity and lack of male sexual development.
Pheidole setsukoae Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole setsukoae

description: Pheidole setsukoae new species
Types Mus. Comp. Zool. Harvard.
Etymology Named after Barbara Setsuko Hamton.
diagnosis A member of the pilifera group uniquely distinguished within not just Pheidole but ants as a whole by the phragmotic condition of the occiput of the major, as illustrated. Also distinctive in the major, although not unique, are the lack of hypostomal dentition; the high, smoothly rounded outline of the promesonotum in side view; the dense parallel longitudinal carinulae that radiate from the antennal fossae and antennal lobes to the sides of the head; and the conulate postpetiolar node. The minor is typical of the " bicarinata complex" (see under bicarinata).
measurements (mm) Holotype major: HW 1.38, HL 1.54, SL 0.62, EL 0.14, PW 0.76. Paratype minor: HW 0.50, HL 0.54, SL 0.60, EL 0.12, PW 0.30.
color Major: concolorous clear yellow with a very slight orange tinge ("light orange").
Minor: clear medium yellow; dorsal surface of head slightly infuscated, i.e., dark yellow to light brownish yellow.
Range Known only from the type locality.
biology Robert J. Hamton (in litt. 1990): the majors and minors were foraging in a single file to dead moths at a blacklight (ultraviolet light used to attract insects).
Figure Upper: holotype, major. Lower: paratype, minor. MEXICO: 59 km north of Culiacan, Sinaloa (Robert J. Hamton). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 597
ПРОТИВОДЕЙСТВИЕ ТЕРРОРИЗМУ – ФИЛОСОФСКИЕ АСПЕКТЫ
Creators: name: РАЖАБОВ, Б.Р.
Publisher: name: Zenodo
Year: 2024

description: В статье рассматривается история возникновения и развития терроризма в мире, её сущность и подлинная природа. Анализируются труды ученых, занимающихся данной проблематикой с учетом современных обстоятельств угрозы терроризма.
Additional file 1: of Validation of CD4+ T-cell and viral load data from the HIV-Brazil Cohort Study using secondary system data
Creators: name: Cassenote, Alex
name: Grangeiro, Alexandre
name: Escuder, Maria
name: Abe, Jair
name: Aluísio Segurado
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Table S1. Proportion and 95% confidence interval for qualitative measures of lowest CD4+ T-cell count before cART per site. Table S2 Proportion and 95% confidence intervals for qualitative measures of viral load before cART per site. Table S3. Descriptive statistics including mean, median, standard deviation (SD) and interquartile range (IQR) for the ten first quantitative measures for CD4+ T-cell and viral load after cART. (DOCX 101 kb)
Multi-pulse fitting of Transition Edge Sensor signals from a near-infrared continuous-wave source
Creators: name: Lee, Jianwei
name: Shen, Lijiong
name: Cerè, Alessandro
name: Gerrits, Thomas
name: Lita, Adriana E.
name: Nam, Sae Woo
name: Kurtsiefer, Christian
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Transition-edge sensors (TES) are photon-number resolving calorimetric spectrometers with near unit efficiency. Their recovery time, which is on the order of microseconds, limits the number resolving ability and timing accuracy in high photon-flux conditions. This is usually addressed by pulsing the light source or discarding overlapping signals, thereby limiting its applicability. We present an approach to assign detection times to overlapping detection events in the regime of low signal-to-noise ratio, as in the case of TES detection of near-infrared radiation. We use a two-level discriminator, inherently robust against noise, to coarsely locate pulses in time, and timestamp individual photoevents by fitting to a heuristic model. As an example, we measure the second-order time correlation of a coherent source in a single spatial mode using a single TES detector.
description: 6 pages, 8 figures
Activation of membrane guanylate cyclase by an invertebrate peptide hormone
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Peptide hormones can stimulate cyclic GMP synthesis through either of two general mechanisms: some peptides activate the cytoplasmic form of guanylate cyclase via a coupling factor called EDRF (endothelium-derived relaxation factor), while others activate the membrane form by interacting directly with an extracellular binding domain of the cyclase molecule itself. We have investigated the mechanism(s) by which crustacean hyperglycemic hormone (CHH), a neuropeptide that regulates energy metabolism in crustaceans, elevates cyclic GMP levels in lobster muscle. Phosphodiesterase inhibitors potentiate the response in intact tissue. This indicates that the primary effect of the peptide is to activate a cyclase rather than inhibit a phosphodiesterase. Methylene blue, a specific inhibitor of the EDRF pathway, does not block the actions of CHH. In addition, nitroprusside, an agent that directly activates the EDRF pathway in vertebrate animals, does not activate guanylate cyclase either in intact or homogenized lobster muscle. This indicates that the EDRF pathway, although prominent in vertebrate muscle, is not found in crustaceans and further suggests that the membrane cyclase is the most likely target of CHH. Membrane and soluble cyclases can be isolated from homogenates of lobster muscle (in a 3.5:1 ratio), and both are stimulated by Mn2+ and inhibited by Ca2+. CHH has no effect on the soluble enzyme. Coupling of CHH receptors to the particulate cyclase, however, remains intact in isolated membranes, thus providing a new model system for the study of receptor/cyclase interactions.
Acute and chronic ethanol treatment in vivo increases malate-aspartate shuttle capacity in perfused rat liver.
Creators: name: Sugano, Tsukasa
name: Thurman, Ronald
name: Handler, Jeffrey
name: Kizaki, Zenro
name: Yoshihara, Harumasa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The effects of acute and chronic treatment with ethanol on transport of reducing equivalents into mitochondria via the malate-aspartate shuttle were studied in perfused rat liver. The shuttle capacity was estimated from the decrease in rates of glucose production from the reduced substrate sorbitol caused by an increase in the NADH/NAD+ ratio in the cytosol due to metabolism of ethanol. The greater the capacity of the malate-aspartate shuttle, the smaller the inhibition of glucose synthesis by ethanol. Glucose synthesis was decreased about 2-fold less in livers from fasted rats treated acutely 2.5 h earlier with ethanol than in untreated controls. Chronic treatment with ethanol for 3-5 weeks prevented completely the decrease in glucose synthesis from sorbitol due to ethanol oxidation. Rates of ethanol uptake were elevated significantly from 69 +/- 7 mumols/g/h in livers from control rats up to 92 +/- 7 mumols/g/h in livers from SIAM rats. Similarly, rates of ethanol uptake were stimulated by chronic ethanol treatment from 71 +/- 6 to 222 +/- 15 mumols/g/h; this increase was largely sensitive to aminooxyacetate. Taken together, these data indicate that flux of reducing equivalents over the malate-aspartate shuttle is increased by both acute and chronic treatment with ethanol and that movement of reducing equivalents from the cytosol into the mitochondria via the malate-aspartate shuttle is an important rate determinant in hepatic ethanol oxidation.
Exclusive Lambda_b -> Lambda l^+ l^- decay in two Higgs doublet model
Creators: name: Aliev, T. M.
name: Savci, M.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Rare Lambda_b -> Lambda l^+ l^- decay is investigated in framework of general two Higgs doublet model, in which a new source of CP violation exists (model III). The polarization parameter, CP asymmetry and decay width are calculated. It is shown that CP asymmetry is a very sensitive tool for establishing model III.
description: 16 pages, 3 figures, LaTeX formatted
Proximity-Induced Spin-Orbit Coupling in Graphene-Bi$_{1.5}$Sb$_{0.5}$Te$_{1.7}$Se$_{1.3}$ Heterostructures
Creators: name: Jafarpisheh, S.
name: Cummings, A. W.
name: Watanabe, K.
name: Taniguchi, T.
name: Beschoten, B.
name: Stampfer, C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The weak intrinsic spin-orbit coupling in graphene can be greatly enhanced by proximity coupling. Here we report on the proximity-induced spin-orbit coupling in graphene transferred by hexagonal boron nitride (hBN) onto the topological insulator Bi$_{1.5}$Sb$_{0.5}$Te$_{1.7}$Se$_{1.3}$ (BSTS) which was grown on a hBN substrate by vapor solid synthesis. Phase coherent transport measurements, revealing weak localization, allow us to extract the carrier density-dependent phase coherence length $l_ϕ$. While $l_ϕ$ increases with increasing carrier density in the hBN/graphene/hBN reference sample, it decreases in BSTS/graphene due to the proximity-coupling of BSTS to graphene. The latter behavior results from D'yakonov-Perel-type spin scattering in graphene with a large proximity-induced spin-orbit coupling strength of at least 2.5 meV.
description: 9 pages, 8 figures
Further Comments on a Vanishing Singlet Axial Vector Charge
Creators: name: Cheng, T. P.
name: Kochelev, N. I.
name: Vento, V.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The recent suggestion of a vanishing flavor-singlet axial charge of nucleon due to a nontrivial vacuum structure is further amplified. A perturbative QCD discussion, applicable for the heavy quark contributions, relates it to the physics of the decoupling theorem. It is also shown that $g_{A}^{0}\simeq 0$ leads to a negative $η'$-meson-quark coupling, which has been found to be compatible with the chiral quark model phenomenology.
description: 6 pages, Latex
Analysis of fibrinogen A alpha-fusion proteins. Mutants which inhibit thrombin equivalently are not equally good substrates.
Creators: name: Byrd, P A
name: Hede, K L
name: Wei, C
name: Lord, S T
name: Colby, T J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We have examined the interaction of thrombin with fibrinogen A alpha chain residues 7-16. Using genetically engineered constructions, we have synthesized in Escherichia coli a fibrinogen A alpha 1-50 fusion protein and seven mutant proteins with single amino acid substitutions. These are: Asp7----Ala, Phe8----Tyr, Glu11----Ala, Gly12----Val, Gly13----Val, Gly14----Val, and Arg16----Leu. Competitive immunoassay of cell lysates showed that all the mutations but one, Arg16----Leu, altered the structure of the protein such that cross-reactivity with the A alpha-specific monoclonal antibody, Y18, was significantly reduced. The fusion proteins were purified and analyzed as thrombin inhibitors and substrates. All the fusion proteins are competitive inhibitors of the amidolytic hydrolysis of Spectrozyme TH, a thrombin-specific chromogenic substrate, with inhibition constants corresponding to that for fibrinogen. We conclude that these 7 amino acid substitutions do not alter thrombin binding to the fusion proteins. The fusion proteins were tested as substrates by monitoring thrombin-dependent peptide release. The natural sequence and three mutants, Asp7----Ala, Glu11----Ala, and Gly14----Val, are good substrates. The other mutants are either poor substrates or are not cleaved by thrombin within A alpha 1-50. These results indicate that residues between Asp7 and Arg16 are critical to efficient peptide hydrolysis, whereas residues outside this region are critical to thrombin binding.
Chemical state of the cysteine residues in the Neurospora crassa plasma membrane H (+)-ATPase.
Creators: name: Rao, U S
name: Scarborough, G A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The plasma membrane H(+)-ATPase of Neurospora crassa was treated with 5,5'-dithiobis(2-nitrobenzoate) to determine its cysteine content and with 2-nitro-5-thiosulfobenzoate to determine its cystine content. Six and seven mol of thiols/mol of H(+)-ATPase were detected in the 5,5'-dithiobis(2-nitrobenzoate) and 2-nitro-5-thiosulfobenzoate reactions, respectively, indicating that 6 of the 8 cysteine residues in the molecule are present as free cysteines and that 2 are present in disulfide linkage. The results of quantitative carboxymethylation experiments using [14C]iodoacetate under nonreducing and reducing conditions fully support this conclusion. Preparations of the ATPase 14C carboxymethylated under the above conditions were treated with trypsin, and the tryptic digests were resolved into hydrophilic and hydrophobic peptide fractions by our recently published procedure (Rao, U.S., Hennessey, J.P., Jr., and Scarborough, G.A. (1988) Anal. Biochem. 173, 251-264). Five of the six labeled free cysteine peptides partitioned into the hydrophilic peptide fraction and were purified and established to contain Cys376, Cys409, Cys472, Cys532, and Cys545. The labeled free cysteine residue in the hydrophobic peptide fraction was identified as either Cys840 or Cys869 by virtue of its presence in a large approximately 21-kDa hydrophobic peptide established previously to begin at Ser660. This in turn identified either Cys840 or Cys869 as one of the disulfide bridge cysteines. The other disulfide bridge cysteine was identified as Cys148 by purification and NH2-terminal sequencing of an additional peptide labeled in the reduced enzyme. The disulfide bridge is therefore between Cys148 and either Cys840 or Cys869. Because Cys148 is present in a putative membrane-embedded sector near the NH2 terminus of the ATPase molecule and Cys840 and Cys869 are present in a similar sector near the COOH terminus, it is possible that the disulfide bridge plays an important structural role in holding the two major membrane-embedded sectors of the molecule, distant in the linear sequence, together.
Polarization Effects in Standard Model Parton Distributions at Very High Energies
Creators: name: Bauer, Christian W.
name: Webber, Bryan R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We update the earlier work of Refs. arXiv:1703.08562 and arXiv:1712.07147 on parton distribution functions in the full Standard Model to include gauge boson polarization, non-zero input electroweak boson PDFs and next-to-leading-order resummation of large logarithms.
description: 24 pages, 7 Figures. arXiv admin note: text overlap with arXiv:1703.08562, arXiv:1806.10157
Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules
Creators: name: AHMAD, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We have recently shown that thrombin-stimulated human platelets have specific, saturable receptors for factor IXa, occupancy of which promotes factor X activation (Ahmad, S. S., Rawala-Sheikh, R., and Walsh, P. N. (1989) J. Biol. Chem. 264: 3244-3251, 20012-20016; Rawala-Sheikh, R., Ahmad, S. S., and Walsh, P. N. (1990) Biochemistry 29, 2606-2611). To study the structural requirements for factor IXa binding to platelets, equilibrium binding studies and kinetic studies of factor X activation were carried out with normal factor IXa and with two variant proteins: factor IXaAlabama (FIXaAL; Asp47----Gly substitution) and factor IXaChapel Hill (FIXaCH; Arg145----His substitution). In the absence of factors VIIIa and X, there were 331 binding sites/platelet for FIXaCH (Kdapp = 2.8 nM), and 540 sites/platelet for FIXaAL (Kdapp = 3.2 nM), compared with 540 sites/platelet (Kdapp = 2.3 nM) for normal factor IXa. The addition of factors VIIIa and X, both at saturating concentrations, had no effect on the number of binding sites for either normal or variant factor IXa, resulted in a decrease in the Kd for normal factor IXa to 0.67 nM, resulted in a suboptimal decrease in Kd for FIXaAL (1.4 nM), and had no effect on the Kd for FIXaCH. Kinetic studies of factor X activation at variable factor IXa concentration confirmed these values of Kd in the presence of factors VIIIa and X. Determination of rates of factor X activation at variable substrate concentrations yielded normal values of catalytic efficiency (kcat/Km) for the variant proteins, thereby indicating that the abnormally low rates of factor X activation obtained were a consequence of the low affinity binding of FIXaAL and FIXaCH to thrombin-activated platelets in the presence of factors VIIIa and X. These studies suggest that the presence of Asp47 and the cleavage of factor IX at Arg145-Ala146 are important structural features required for specific, high affinity factor IXa binding to platelets in the presence of factors VIIIa and X.
$^{6}_{ΛΛ}$He as a $ΛΛ$ interaction constraint
Creators: name: Carr, S. B.
name: Afnan, I. R.
name: Gibson, B. F.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The Nijmegen OBE potential D is SU(3) rotated to model the strangeness -2 sector of the baryon-baryon force. Soft core repulsion is introduced to regularize the singular nature of the OBE functions. The strength of the $^1$S$_0$ $t=0$ interaction is adjusted to model three scenarios: (1) a bound state, (2) a narrow virtual, or antibound, state, and (3) an unbound state in which the force is weakly attractive. Using a separable approximation to these potentials, the binding energy of $^{6}_{ΛΛ}$He is calculated in an $ΛΛα$ model. The resultant binding energies suggest that the strength of the $^1$S$_0$ $t=0$ $ΛΛ$ and the $nn$ interactions should be similar, if the coupling between the $ΛΛ$ and $ΞN$ channels is taken into consideration.
description: 27 pages,2 eps figures
The incoherent part of the spin-wave polarization operator in the t-J model
Creators: name: Murray, D. W.
name: Sushkov, O. P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: A calculation of the spin-wave polarization operator is very important for the analysis of the magnetic structure of high temperature superconductors. We analyze the significance of the incoherent part of the spin-wave polarization operator within the framework of the t-J model. This part is calculated analytically for small doping with logarithmic accuracy. We conclude that the incoherent part of the spin-wave polarization operator is negligible in comparison with the coherent part.
description: 7 pages, 6 figures
Quantum sensing using imbalanced counter-rotating Bose--Einstein condensate modes
Creators: name: Pelegrí, G.
name: Mompart, J.
name: Ahufinger, V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A quantum device for measuring two-body interactions, scalar magnetic fields and rotations is proposed using a Bose--Einstein condensate (BEC) in a ring trap. We consider an imbalanced superposition of orbital angular momentum modes with opposite winding numbers for which a rotating minimal atomic density line appears. We derive an analytical model relating the angular frequency of the minimal density line rotation to the strength of the non-linear atom-atom interactions and the difference between the populations of the counter-propagating modes. Additionally, we propose a full experimental protocol based on direct fluorescence imaging of the BEC that allows to measure all the quantities involved in the analytical model and use the system for sensing purposes.