cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of cypin in the regulation of the ubiquitin-proteasome system
Creators: name: Gandu, Srinivasa R.
Publisher: name: No Publisher Supplied
Year: 2024

description: Proteome homeostasis is crucial for the proper functioning of the neurons. Disruptions in homeostasis lead to dysregulation in cellular functions, affecting neuronal functions and synaptic plasticity and ultimately leading to cell death. Protein homeostasis depends on efficient transcription, translation, and subsequent removal by protein degradation systems. Two major degradation systems, the Ubiquitin proteasome system, and the Autophagy lysosome pathway, play crucial roles in removing short-lived and damaged or dysfunctional proteins and membrane-bound proteins and organelles, respectively. Post-translational modifications of proteins with ubiquitin (Ub), a key regulator in the protein degradation systems, are implicated in neuronal development by regulating synapse formation and maturation, signal transduction, and synaptic plasticity through proteasome-dependent and independent mechanisms. Despite the mounting evidence identifying the role of ubiquitin in neuronal homeostasis and function, not much is known about the mechanism through which these substrates are targeted. In this dissertation, we explored a novel role of cypin (cytosolic PSD-95 interactor) in promoting the ubiquitination of proteins while negatively affecting proteasome activity when overexpressed. We further explored the role of cypin in promoting proteasome-independent ubiquitin linkages (K63-Ub), which is known to play a crucial role in synaptic plasticity, via UBE4A (a key player in promoting K63-Ub linkages). We found cypin overexpression led to an increase in the levels of synaptic proteins, K63-polyubiquitination of PSD-95, a major scaffolding protein at the postsynaptic density, and intracellular Ca+2 levels. Proteome-wide studies revealed cypin overexpression altered the protein ubiquitination pathway and promoted synaptogenesis in in vitro studies. Further analysis of proteome changes at the synapses identified cypin overexpression playing a major role in pre and postsynaptic functions, postsynaptic being predominant. Taken together, data presented here identified a novel role for cypin in regulating the proteasome activity and proteasome-independent post-translational modifications (PTM) to regulate the synaptic architecture.
Saxons in Deptford
Creators: name: Gaimster, M�Rit
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 11 (2), 31-37
description: Article on the discovery and excavation of two Anglo-Saxon inhumation burials at a site behind the Dover Castle public house on the northern side of Deptford Broadway. One burial was furnished with grave goods including a decorated gilt-bronze pendant and fittings from a small wooden casket, and could be dated to the seventh century. The author discusses the context of Anglo-Saxon Deptford, and of preceding settlement relating to the Roman period.
The Priory of St Leonard Stratford-by-Bow and Parish Church of St Mary Bromley-by-Bow
Creators: name: Hawkins, Duncan
name: Phillpotts, Chris
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 11 (2), 38-46
description: Account of the history of the Priory of St Leonard's Stratford-at-Bow, a house of Benedictine nuns, and its successor, the parish church of St Mary Bromley-by-Bow, from medieval and post-Dissolution documentary sources, including descriptions of the fabric of the church and of its piecemeal destruction during the course of the nineteenth and twentieth centuries.
MOESM1 of A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development
Creators: name: Yang, Dong
name: Xu, Aishi
name: Shen, Pan
name: Gao, Chao
name: Zang, Jiayin
name: Qiu, Chen
name: Ouyang, Hongsheng
name: Jiang, Ying
name: He, Fuchu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. The supplementalÂ descriptions of part of the results and the supplemental methods, tables and figures.
title: 02_0484
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A medieval dock at Waltham Abbey, and a consideration of medieval measurements
Creators: name: Huggins, Peter J
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 11 (2), 47-51
description: Article on a timber-framed and planked dock found during excavations across an ancient waterway called Longpool at Waltham Abbey from 1996 to 1998. Following a description of the remains of the dock and its phases of use, the author discusses the measurements used in the dock's construction -- in particular the medieval rod or perch -- and the documentary and archaeological evidence for their use generally.
History v. Archaeology: the City of London on the eve of the Great Fire of 1666, a case study
Creators: name: Biddulph, Kim
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (3), 59-63
description: The author considers the archaeological, documentary, literary and pictorial evidence indicating the appearance and characteristics of the City of London in the period immediately before the Great Fire of 1666, and explains how these different forms of evidence can reveal different aspects of the city, and can complement each other.
title: 02_0858
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A 17th-century delftware tile group from 31 James Street, Covent Garden WC2
Creators: name: Brown, John
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (3), 64-71
description: Report on a substantial assemblage of delftware tiles, recovered from a backfilled eighteenth-century cesspit revealed during excavations at 31 James Street, Covent Garden. The tiles comprised polychrome floor tiles, probably dating from the late-sixteenth to the first half of the seventeenth century; and three groups of blue and white tin-glazed wall tiles dating from the second half of the seventeenth to the early-eighteenth century. These consisted of two groups depicting mythological sea creatures and biblical scenes respectively, and miscellaneous fragments with unidentified themes.
Additional file 1: of Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus
Creators: name: Jing, Chendi
name: Liu, Chenghua
name: Liu, Fangjie
name: Gao, Yaping
name: Liu, Yu
name: Guan, Zhangchun
name: Xuan, Bo
name: Yu, Yanyan
name: Yang, Guang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S1. HlgABC, LukSF, and LukED proteins were expressed and analyzed by SDS-PAGE and Coomassie blue staining. (PDF 231 kb)
Excavations at 211 Long Lane, Southwark Part 1: prehistoric Neckinger-side environment in Southwark and its implications for prehistoric communities
Creators: name: Allen, Michael J
name: Scaife, Robert G
name: Cameron, Nigel G
name: Stevens, Chris J
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (3), 73-81
description: Examination of deposits such as peat and alluvium on the northern edge of the Bermondsey eyot at 211 Long Lane, Southwark, provided the opportunity to define the area's past topography and geoarchaeology, and examine issues of human settlement patterns and exploitation. The report, the first of two parts, discusses the peat and floodplain deposits in terms of the geology and palaeogeography; prehistoric activity in the vicinity; excavated evidence of the geotopography and the Neckinger floodplain; and life and the environment on the eyot edge.
Excavations at 211 Long Lane, Southwark Part 2: Romano-British pasture to post-medieval tanneries
Creators: name: McKinley, Jacqueline I
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (4), 87-94
description: Second of two reports on excavations in advance of development at 211 Long Lane, Southwark. The geo-topography of the site is described, consisting partly of a gravel eyot and partly of peat deposits overlying alluvial clays and sands. Prehistoric evidence from the site was described in Part I; Part II summarises evidence of Romano-British agricultural activity, probably related to settlements at Bermondsey or Southwark, followed in the late-twelfth or early-thirteenth century by a series of causewayed ditches, possibly linked to the establishment of Long Lane as a route across the marshes which then characterised the area. The area appears to have continued to be used for cultivation until the early post-medieval period, but by 1746 the northern frontage of Long Lane was largely occupied by tanners' yards, characterised by a number of horn core or barrel-lined pits. A sample of 100 horn cores was subjected to a detailed examination. The location of the tanning pits shifted northward during the eighteenth and nineteenth centuries, with the construction of blocks of timber tanks over the northern part of the site. The earlier tanning pits were backfilled with domestic debris during the nineteenth century, including a large quantity of ceramics. Animal bones suggest that remains largely represent domestic refuse of low-status foodstuffs.
MOESM1 of Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis
Creators: name: Hao, Xiahui
name: Luo, Ling
name: Jouhet, Juliette
name: Rébeillé, Fabrice
name: Maréchal, Eric
name: Hu, Hanhua
name: Pan, Yufang
name: Tan, Xiaoming
name: Chen, Zhuo
name: You, Lingjie
name: Chen, Hong
name: Wei, Fang
name: Gong, Yangmin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1: Figure S1. Acyl-CoA thioesterase activity of recombinant ptTES1 purified from E. coli. The time-dependent CoA release catalyzed by ptTES1 was monitored at A412 for various substrate concentrations. Reactions were performed at room temperature in mixtures that contain 25 μg recombinant ptTES1 protein, 50 mM KCl, 10 mM HEPES (pH7.5), 0.3 mM DTNB, and various concentrations of acyl-CoA substrates including malonyl-CoA (A), 10:0-CoA (B), 14:0-CoA (C), 16:0-CoA (D), 16:1-CoA (E), 18:0-CoA (F), 18:1-CoA (G), and 20:5-CoA (H).
Waste and its disposal in Southwark
Creators: name: Hooper, Jill
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (4), 95-100
description: The author considers the definition of waste and its terminology, and examines documentary and archaeological evidence for the various methods of waste disposal used in Southwark during the medieval and post-medieval periods, including the recycling or re-sale of some materials.
MOESM2 of Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis
Creators: name: Hao, Xiahui
name: Luo, Ling
name: Jouhet, Juliette
name: Rébeillé, Fabrice
name: Maréchal, Eric
name: Hu, Hanhua
name: Pan, Yufang
name: Tan, Xiaoming
name: Chen, Zhuo
name: You, Lingjie
name: Chen, Hong
name: Wei, Fang
name: Gong, Yangmin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 2: Figure S2. Western blotting analysis of protein lysates with α-ptTES1 antibody. The molecular weight marker is labeled on the left. Lane 1, 4 ng of total protein lysate from approx. 1.5 × 106 cells; Lane 2, 4 ng of the protein lysate from the plastid fraction isolated from approx. 6 × 108 cells; Lane 3, 400 ng of the protein lysate from the cytoplasm fraction from approx. 1.3 × 106 cells. Coomassie brilliant blue (CBB) staining is shown as a loading control.
title: Descripcíon histórica y cronológica de las dos piedras que con ocasion del nuevo empedrado que se està formando en la plaza principal de México, se hallaron en ella el año de 1790..., por Don Antonio de Leon y Gama
Creators: name: León y Gama, Antonio
name: Impr. F. De Zoeñiga. Imprimeur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: pl. dépl.
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Liber, Mt m 6797
Promoting differentiation of human adipose mesenchymal stem cells to oligodendrocyte-like cells and neuron-like cells through coculture on decellularized sciatic nerves
Creators: name: Valencia-Salgado, Carlos
name: Jacobo-Arreola, Selene
name: Said-Fernandez, Salvado
name: Soto-Dominguez, Adolfo
name: Camacho-Morales, Alberto
name: Martinez-Rodriguez, Herminia
name: Rodriguez-Rocha, Humberto
name: Delgado-Gonzalez, Paulina
name: Quiroz-Reyes, Adriana
name: Islas, Jose
name: Garza-Treviño, Elsa
Publisher: name: Scientific Letters
Year: 2022

description: We evaluated cell markers of oligodendrocyte-like cells (OLC) and neuron-like cells (NLC) differentiation from human adipose tissue-derived mesenchymal stem cells (hADSCs) cocultured on decellularized sciatic nerves. OLC and NLC were incubated at a 10:1 ratio with decellularized rat nerves. We estimated the percentage of myelin basic protein (MBP)- and neurofilament protein (NFP)-positive cells. OLC and NLC cocultures showed an increase in positive cells for MBP and proteolipid protein (PLP) markers. Oligodendrocytes and neurons cocultured with sciatic nerve scaffolds promoted myelination by OLC within three days, which remained stable for at least 21 days. We propose a reproducible experimental strategy for promoting sciatic nerve myelination by coculturing hADSCs-derived OLC and NLC in nerve scaffolds.
description: Scientific Letters, Vol. 1 No. 1 (2022)
title: Le développement des compétences culturelles chez les élèves de 1-2 P à travers la création et la représentation d'un spectacle de marionnettes.
title: Le développement des compétences culturelles chez les élèves de 1-2 P à travers la création et la représentation d'un spectacle de marionnettes.
titleType: AlternativeTitle
Creators: name: Tourlonias, Ludivine
Publisher: name: Unknown
Year: 0
Subjects: subject: Culture
subject: marionnettes
subject: démarche de projet
subject: séquence

description: En observant, lors de nos différents stages, que la musique était régulièrement enseignée en soutien à d’autres disciplines (apprentissage des chiffres au travers des comptines, d’une règle de grammaire, etc.), qu’il existait peu de moyens d’enseignement en musique basé sur une progression des apprentissages et que l’axe A 14 Mus - Culture de la discipline musique, n’était pas souvent enseigné, nous avons créé une séquence didactique ayant pour but de développer des compétences culturelles chez des élèves de 1-2P en partant d’une histoire contée dans un livre. Afin d’évaluer le développement des compétences culturelles chez les élèves, nous avons déterminé trois types de connaissances à développer chez les élèves : les connaissances déclaratives (telle que donner les caractéristiques de l’Opéra en tant qu’art lyrique), procédurales (telle qu’organiser les chaises le public) et métaprocédurales (déclaration de la procédure de la connaissance procédurale de l’attitude pendant le spectacle en tant que spectateur). Nous avons procédé à une recherche qualitative dans laquelle nous avons observé uniquement notre classe de stage. Nous avons procédé à des entretiens du groupe classe, des enregistrements audio et vidéo et des observations consignées dans un journal de bord. Globalement, nous avons pu observer des développements de toutes les connaissances à différents niveaux.
Additional file 2: of Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus
Creators: name: Jing, Chendi
name: Liu, Chenghua
name: Liu, Fangjie
name: Gao, Yaping
name: Liu, Yu
name: Guan, Zhangchun
name: Xuan, Bo
name: Yu, Yanyan
name: Yang, Guang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S2. Selection of HlgB-neutralizing antibodies from a naïve human Fab phage library. After three rounds of panning, 168 phage clones were further determined by ELISA, and 16 clones were then subjected to nucleotide sequencing (group 1: OD450nm ≤ 0.4; group 2: 0.4 < OD450nm < 0.8; group 3: OD450nm ≥ 0.8). (PDF 16 kb)
Bronze Age occupation of Newbury Park: further evidence of prehistoric Redbridge
Creators: name: Hulka, Karl
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (4), 101-108
description: Report on an archaeological excavation during 2002 on the site of the King George V Hospital, Eastern Avenue, Newbury Park. Evidence of Late Bronze Age to Late Iron Age occupation was identified, including boundary ditches, postholes and quarry pits. Environmental analysis suggests a landscape of mixed woodland with large clearings of scrub and meadow vegetation. A pottery assemblage of 224 sherds weighing approximately 2.5kg was recovered, most of which belonged to an early phase of the post-Deverel-Rimbury tradition of the Late Bronze Age. Includes
Modelling the Costs of Final Sub-Circuits in Residential Electrical Installations
Creators: name: Olawumi, Timothy O.
Publisher: name: figshare
Year: 2022
Subjects: subject: 120203 Quantity Surveying
subject: FOS: Civil engineering

description: Previous researchers have developed models for determining building durations in Nigeria and Hong Kong respectively; however little forage has been made in the area of electrical services, a recent research work deals with the measurement of electrical services in buildings; but there is yet not a model to determine the probable cost of electrical services in residential buildings. Therefore, the aim of this study is to develop a cost model for predicting the costs of final sub-circuits in residential electrical installations using multiple regression techniques and linear regression techniques, based on data generated from 33 sets of drawings- Architectural and Electrical drawings of Bungalows (17 bungalows) and Duplexes (16 drawings) from which also, priced bill of quantities were generatedAlso the current market prices of electrical items as well as site observation of electrical technician’s productivity were also carried out with interviews which were used in calculation of unit rates. In achieving the aim of this research work, six (6) cost models were developed; of which 5 of the 6 models will fit in real life cost prediction works. The first two (2) models was developed using multiple regression analysis to determine the final sub-circuit cost of electrical installation with Coefficient of Determination, R2 of 0.968 and 0.980 respectively. The other models were developed using linear regression analysis technique. The third model assesses the influence of GFA on final circuit cost with R2 of 0.172. The fourth model uses the number of lighting points to determine the length of cable with R2 of 0.823. The fifth and sixth models use the length of cable to determine the length of conduits with R2 of 0.559 and 0.947 respectively. In assessing the predictive power of the cost models, model validation was carried out using seven (7) floors of 3 bungalows and 2 duplexes. The model validations/comparison further confirmed the validity of the models earlier generated as valid enough to be used as a basis in cost prediction of residential electrical installation.
Dyeing of Silk through Iron Ion-Induced Formation of Hydrophobic Lignin Coatings
Creators: name: Ma, Ying
name: Lu, Qinfu
name: Lv, Shanshan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Plant Biology

description: There is a continuous demand for a specific type of Chinese silk fabric, which is one of China’s national intangible cultural heritage items called Xiang-Yun-Sha. Xiang-Yun-Sha is silk fabric dyed using the vegetable dyes from a yam and the mud from the Pearl Delta River. The ingenious and sophisticated dyeing process inspires us to explore new dyes for silk. Through learning from the traditional mud dyeing process of Xiang-Yun-Sha, especially the contents of the mud, lignin and iron species are recognized as key factors. Yet little attention has been dedicated to lignin as a dye despite its wide applications. In this study, the feasibility of using lignin to dye silk is investigated using sodium lignosulfonate and alkaline lignin as model systems. Thanks to their advantageous polyphenolic features, such as stacking tendency and ability to form stable complexes with iron ions, lignin-related compounds show excellent performance in serving as dyes by themselves, as well as protective coatings for other dyes; the dyed silk fabric could inherit anti-ultraviolet property from lignin. Considering that iron is inexpensive and that leftover lignin is a vastly underutilized biomass resource, this study offers a promising strategy to exploit the enormous potential of these naturally occurring materials by developing high value-added products.
The new Medieval Gallery at the Museum of London
Creators: name: Gordon, David
name: Gooch, Tracey
name: Campbell, Louise
name: Brown, Sophie
name: Agate, Andy
Publisher: name: Archaeology Data Service
Year: 2006

description: London Archaeologist, 11 (4), 109-110
description: Article on the new gallery at the Museum of London presenting a wide variety of aspects of medieval London, from the `glamorous' to the mundane, and incorporating a range of technological enhancements and interactive exhibits.
S18 Quality of Evidence (CINeMA), Femoral Neck BMD
Creators: name: Deng, Jiawen
name: Huang, Emma
name: Silver, Zachary
name: Zheng, Elena
name: Kavanagh, Kyra
name: Wen, Aaron
name: Zhou, Fangwen
name: Panicker, Jannusha
name: Hou, Winston
name: Sanger, Stephanie
name: Dobransky, Johanna
name: Cheng, Wei
name: Grammatopoulos, George
Publisher: name: figshare
Year: 2020
Subjects: classificationCode: 320223
subject: Rheumatology and arthritis

description: S18 Quality of Evidence (CINeMA), Femoral Neck BMD
MOESM3 of Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis
Creators: name: Hao, Xiahui
name: Luo, Ling
name: Jouhet, Juliette
name: Rébeillé, Fabrice
name: Maréchal, Eric
name: Hu, Hanhua
name: Pan, Yufang
name: Tan, Xiaoming
name: Chen, Zhuo
name: You, Lingjie
name: Chen, Hong
name: Wei, Fang
name: Gong, Yangmin
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Plant Biology

description: Additional file 3: Figure S3. Molar profiles of fatty acids in MGDG (A), SQDG (B), PC (C), and DGDG (D) from P. tricornutum wild-type and ptTES1 knockout line Tes-KO cells grown in nitrogen-replete F/2 media for 8 days. Values are the average of three experiments (± SD). MGDG, monogalactosyldiacylglycerol; SQDG, sulphoquinovosyl diacylglycerol; PC, phosphatidylcholine; DGDG, digalactosyldiacylglycerol.
IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus
Creators: name: Zhang, Ping
name: Zhai, Jianzhao
name: Wang, Kefen
name: Wu, Yongkang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Defects in apoptotic cell clearance is a pathogenic factor in systemic lupus erythematosus (SLE). This study screened potential pathogenic single nucleotide polymorphisms (SNPs) related to anti-apoptosis from an SLE family and explored their contribution to SLE susceptibility in Chinese women. Four SNPs (IKBKE rs15672, BANK1 rs12640056, BANK1 rs6842661, and NFKBIA rs1957106) with potential SLE susceptibility were analyzed for clinical characteristics between 567 patients with SLE and 345 healthy control subjects. IKBKE rs15672 G/A and BANK1 rs12640056C/T polymorphisms were associated with SLE susceptibility (rs15672 A vs G, P = 0.028, OR = 1.25, 95% CI = 1.02–1.52; rs12640056 T vs C, P = 0.015, OR = 0.78, 95% CI = 0.64–0.95, respectively). In addition, patients with AA+GA genotypes of IKBKE rs15672 had higher positive rates of anti-SSB antibodies (q = 0.008) and lower positive rates of anti-RIB antibodies (q = 0.024) than those with the GG genotype. There were no significant differences in BANK1 rs12640056 between different genotypes and clinical characteristics. IKBKE rs15672 G/A and BANK1 rs12640056C/T polymorphisms are associated with susceptibility to SLE in Chinese women. This highlights the important role of these two SNPs in this disease and suggests that multiple genes from these pathways are candidates for functional studies and therapeutic targets.
The Manor of Huscarls and the Beddington Roman villa
Creators: name: Phillips, John
Publisher: name: Archaeology Data Service
Year: 2011

description: London Archaeologist, 11 (5), 122-123
description: Brief overview of settlement at the site from the Late Bronze Age on, focussing on the Roman villa and the Saxon cemetery. Suggests that the medieval manor may have occupied the same area as the Roman villa estate. PP-B
On the Campden Hill spur: excavations at Vicarage Gate House, Kensington, W8
Creators: name: Wragg, Eliott
name: Moore, Peter
Publisher: name: Archaeology Data Service
Year: 2011

description: London Archaeologist, 11 (5), 130-135
description: Report on a multi-period site, which found Bronze Age, Iron Age, Roman, and post-medieval features. PP-B
Roman, medieval and post-medieval activity at West Smithfield: recent work at 8-22 Smithfield Street and 30-38 Hosier Lane, City of London
Creators: name: Treveil, Phil
name: Watson, Bruce
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (6), 143-150
description: Article describing archaeological work carried out before and during development of 8--22 Smithfield Street and 30--38 Hosier Lane. A range of evidence was found including Roman rubbish pits and evidence indicating Roman burials nearby; rubbish and cess pits with a range of dates from the early medieval period through to the seventeenth century; gravel quarrying dating from the late-thirteenth through to fifteenth centuries; and post-medieval structural features, including cellars. A range of environmental evidence was recovered, and there is a separately authored contribution on
Graffiti at St Paul's: the cleaning and repair of the west end of the cathedral 2003-5
Creators: name: Schofield, John
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (6), 151-156
description: Article about the archaeological monitoring of several cleaning and refurbishment recording projects t St Paul's Cathedral in the City of London in 2003--5, focusing on the west end of the cathedral. The article gives an overview of the history of the construction of this part of the cathedral, before going on to describe a range of historic graffiti dating to between 1759 and the 1790s from around the west doors; and from inside the cupola of the south-west tower, the dates inscribed being 1788. The construction and history of the west steps is also described.
title: Titre_Réunion des amateurs de chiens d'arrêt français. 40, rue des Mathurins. - Paris. Allocution du président à l'Assemblée générale du 27 mai 1893
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Titre
Evolutionary and genomic insights into the long-term colonization of Shigella flexneri in animals
Creators: name: Liang, Junrong
name: Zhu, Zhen
name: Lan, Ruiting
name: Meng, Jing
name: Vrancken, Bram
name: Lu, Shan
name: Jin, Dong
name: Yang, Jing
name: Wang, Jianping
name: Qin, Tian
name: Pu, Ji
name: Zhang, Li
name: Dong, Kui
name: Xu, Mingchao
name: Tian, Huaiyu
name: Jiang, Taijiao
name: Xu, Jianguo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The enteroinvasive bacterium Shigella flexneri is known as a highly host-adapted human pathogen. There had been no known other reservoirs reported until recently. Here 34 isolates obtained from animals (yaks, dairy cows and beef cattle) from 2016–2017 and 268 human S. flexneri isolates from China were sequenced to determine the relationships between animal and human isolates and infer the evolutionary history of animal-associated S. flexneri. The 18 animal isolates (15 yak and 3 beef cattle isolates) in PG1 were separated into 4 lineages, and the 16 animal isolates (1 yak, 5 beef cattle and 10 dairy cow isolates) in PG3 were clustered in 8 lineages. The most recent human isolates from China belonged to PG3 whereas Chinese isolates from the 1950s–1960s belonged to PG1. PG1 S. flexneri may has been transmitted to the yaks during PG1 circulation in the human population in China and has remained in the yak population since, while PG3 S. flexneri in animals were likely recent transmissions from the human population. Increased stability of the large virulence plasmid and acquisition of abundant antimicrobial resistance determinants may have enabled PG3 to expand globally and replaced PG1 in China. Our study confirms that animals may act as a reservoir for S. flexneri. Genomic analysis revealed the evolutionary history of multiple S. flexneri lineages in animals and humans in China. However, further studies are required to determine the public health threat of S. flexneri from animals.
Excavations at 97-101 and 103 Union Street, Southwark
Creators: name: Capon, Les
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (6), 157-162
description: Article on two excavations carried out in 1998 and 2000 in Union Street, London SE1, uncovering a range of Roman settlement evidence and a single Roman burial, followed by post-medieval activity in the form of a large ditch and a series of eighteenth-century tenements.
Archiving London's digital archaeological data: problems, pragmatism... and progress?
Creators: name: Evans, Edward
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (6), 163-167
description: The article explores the tensions inherent in the creation and negotiation of workable deposition standards for archaeological archives, and how this potentially informs the histories that are presented. The author draws on his experiences at the London Archaeological Archive and Research Centre (LAARC), and the release of the Archaeological Archives Forum's consultation document on standards for archaeological archives.
Implementation and Impact of the Magic Table for people living with dementia in care homes and day services
Creators: name: Fox, Rachel
Publisher: name: Leeds Beckett University
Year: 2024

description:  There are a growing number of people living with dementia in the UK and one third live in  long term care settings, with a need to offer non-pharmacological interventions in these  settings being essential. One means to do so is through technology, such as the Magic  Table (MT), an interactive game projector. There is limited evidence regarding the  implementation and impact of the MT, including that of times of heightened infection control,  such as the Covid-19 pandemic. The aim of this thesis is to understand the features required  for successful implementation and the impact of using the MT with people living with  dementia in care homes and/or attending day services. As this PhD was conducted during  the Covid-19 pandemic, the impact of the Covid-19 pandemic on the use of the MT is  explored within this research. This PhD comprises two studies. Study one aimed to  understand the impact of the Covid-19 pandemic on the use of the MT, exploring MT usage  in the UK and Netherlands during the Covid-19 pandemic and adaptations required to  continue usage, using an online questionnaire (n=48) and interviews with UK participants (n=3). Study two, aimed to understand the optimal implementation and impact of the MT for  people living with dementia, using an observational and interview design. This included designing a new observational tool to conduct observations (n=9) of players interactions with  the MT in care homes (n=2) and day services (n=2) alongside semi-structured interviews  with people living with dementia (n=6) and staff members (n=7).  The findings indicate the MT is an activity, that can be used with people living with dementia  at times of heightened infection control measures, with increasing planning and smaller  group numbers, yet guidance of how to implement safely is required. Study two found  inconsistencies in the ways the MT is being used at an organisational and staff level,  including knowledge of MT features, flexibility in implementation approaches and the role of  staff as facilitators, all limiting successful implementation. The role of people living with  dementia in the implementation of the MT requires greater acknowledgement. Should the  gaps in implementation be addressed, the MT can offer benefits including reducing time  people living with dementia spend sedentary, the opportunity for social interaction and reducing behaviours that others finding challenging. Recommendations are provided to  enhance guidance for use of the MT, for MT providers, organisations and staff members to enhance successful implementation and in doing so increase impact.
Saxon activity at 15-17 Long Acre, City of Westminster
Creators: name: Capon, Les
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (7), 171-176
description: Article on an excavation in 1999 at 15--17 Long Acre in Covent Garden, London, presenting evidence of Saxon activity at the site, which spanned the fifth or sixth to ninth centuries; including a discussion on Middle Saxon industry, economy and diet.
Supporting Material - Molecular Ecology
Creators: name: Luzuriaga-Aveiga, Vanessa
name: Weir, Jason T.
name: Ugarte, Mauricio
Publisher: name: figshare
Year: 2022
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: FOS: Biological sciences
subject: 60409 Molecular Evolution
subject: 60411 Population, Ecological and Evolutionary Genetics

description: The following data corresponds to the Supplemental Information of 'Distinguishing genomic homogenization from parapatric speciation in an elevationally replacing pair of Ramphocelus tanagers'. Appendix S1:
Table S1: Pairwise Hudson's FST between populations.Table S2: Results of cline model testing in HZAR for genome-wide hybrid index and two datasets of plumage colouration score, reflectance peak and red proportion in a feather.Table S3: Blast results of overlapping and nearby genes found at the genomic regions of high FST between parental populations.Table S4: Parameter estimates and 95% confidence intervals of best fit demographic model (model 2, Fig. 4). Table S5: Summary of SNP datasets included in our analyses.Figure S1: 0.5 isocline of the hybrid zone.Figure S2: Best fit model of geographic clines of mean proportion of each feather colouration scores along the transect.Figure S3: An example of plumage colouration differentiation between parental and hybrid populations for the rump patch.
Figure S4: Genome-wide association with plumage colouration scores.Figure S5: ADMIXTURE’s cross-validation scores for 6 different K clusters across all individuals of the hybrid zone.
Appendix S2: Results of GWAS.Appendix S3: Sample information.Appendix S4: Results of song analysis.Input files: Input files used for demographic modelling in fastsimcoal2.
The Millbank Penitentiary: excavations at the Chelsea School of Art and Design
Creators: name: Edwards, Catherine
name: Hulka, Karl
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (7), 177-183
description: Article describing the results of a two-phase watching brief, in 2001 and in 2004, at the Royal Army Medical College, Millbank, Westminster, at the site of Millbank Penitentiary. An account is given of the archaeological and historical background, including the design of the penitentiary, which was based on the `panopticon' model of a hexagon surrounded by six pentagons. The article then describes the geology of the site and the remains recorded of the fifth and sixth pentagons, the moat, and other structures.
An ornamental structure from the Elizabethan garden at Carew Manor, Beddington
Creators: name: Phillips, John
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (7), 185-191
description: Account of the discovery and excavation in the grounds of Carew Manor, Beddington, of a fragment of an ornamental garden structure and part of a culvert for draining water from the River Wandle. The remains were part of the Renaissance-style garden laid out by Sir Francis Carew in the second half of the sixteenth century.
Supplementary Material for: N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Creators: name: Benterud, T.
name: Ystgaard, M.B.
name: Manueldas, S.
name: Pankratov, L.
name: Alfaro-Cervello, C.
name: Florholmen, G.
name: Ahmed, M.S.
name: Sandvik, L.
name: Norgren, S.
name: Bjørås, M.
name: Baumbusch, L.O.
name: Solberg, R.
name: Saugstad, O.D.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: Perinatal asphyxia and ensuing reoxygenation change the antioxidant capacity of cells and organs. Objectives: To analyze the neuroprotective effect of the antioxidant N-acetylcysteine amide (NACA) after perinatal hypoxia-reoxygenation with an emphasis on proinflammatory cytokines and the transcription factor NF-κB in the prefrontal cortex of neonatal pigs. Methods: Twenty-nine newborn pigs, aged 12-36 h, were subjected to global hypoxia and hypercapnia. One sham-operated group (n = 5) and 2 experimental groups (n = 12) were exposed to 8% oxygen, until the base excess was -20 mmol/l or the mean arterial blood pressure fell to <20 mm Hg (asphyxia with NACA or saline). The pigs were observed for 9.5 h after hypoxia. Samples of prefrontal cortex and plasma were analyzed. Results: Cortex: there was no significant difference in mRNA expression between the intervention groups regarding IL-1β, IL6, TNFα, MMP2, MMP9 or IL18. Pigs exposed to hypoxia-reoxygenation and treatment with NACA (NACA-pigs) had a significantly lower protein concentration of IL-1β than pigs treated with saline (placebo controls), i.e. 8.8 ± 3.9 versus 16.8 ± 10.5 pg/mg protein (p = 0.02). The activation of the transcription factor NF-κB (measured as the fold-change of phosphorylated p65Ser 536), was reduced in the NACA-pigs when compared to the placebo controls (5.2 ± 4.3 vs. 16.0 ± 13.5; p = 0.02). No difference between the intervention groups regarding brain histopathology or in the levels of 8-oxoguanine measured in the prefrontal cortex were observed. Plasma: the NACA-pigs had a stronger reduction of TNFα in the first 30 min following asphyxia compared with the placebo controls, i.e. 36 (30-44) versus 24 (14-32)% (p = 0.01). Conclusion: The reduced levels of the pivotal inflammatory markers IL-1β and TNFα and the transcription factor NF-κB may indicate that NACA has possible neuroprotective effects after perinatal asphyxia.
Additional file 3: of Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus
Creators: name: Jing, Chendi
name: Liu, Chenghua
name: Liu, Fangjie
name: Gao, Yaping
name: Liu, Yu
name: Guan, Zhangchun
name: Xuan, Bo
name: Yu, Yanyan
name: Yang, Guang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S3. YG8â 1 (a), YG8â 2 (b), and YG8â 3 (c) were expressed and analyzed by reducing and nonreducing SDS-PAGE. (PDF 288 kb)
Additional file 1: of VIPER: variability-preserving imputation for accurate gene expression recovery in single-cell RNA sequencing studies
Creators: name: Chen, Mengjie
name: Zhou, Xiang
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Details of modeling for the dropout event adjustment and method comparison to scImpute. (PDF 200 kb)
London's earliest Roman bath-houses?
Creators: name: Pringle, Susan
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (8), 205-209
description: The article examines the distributions of finds of four types of small box flue, as well as some other specialised types of tile in use in first-century AD London. The tile forms are thought to have been in use in hypocausts or bath-houses, and the author discusses this and other evidence for the presence of these features in early Roman London.
Merton Priory
Creators: name: Rowsome, Peter
Publisher: name: Archaeology Data Service
Year: 2007

description: London Archaeologist, 11 (8), 210-211
description: Short article presenting an overview of archaeological research into the Augustinian priory of St Mary Merton, Surrey, and previewing the publication of a report on excavations at the site between 1976 and 1990.