cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The interfacial region of dipalmitoylphosphatidylcholine bilayers is perturbed by fusogenic amphipaths
Creators: name: Zheng, Lianxing
name: Lentz, Barry R.
name: Převrátil, Jan
name: Wu, Jogin R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Several structural methods were used to probe the influence of three fusogenic and four nonfusogenic amphipaths on large, unilamellar dipalmitoylphosphatidylcholine (DPPC) vesicles. For four of these structural measurements there was a correlation observed between the ability of an amphipath to favor poly(ethylene glycol) (PEG)-induced fusion and the structural perturbation reported by each method. First, the fluorescence anisotropy of 1-[4-(trimethylamino)phenyl]-6-phenyhexa-1,3,5-triene (TMA-DPH), which probes the upper region of the bilayer, decreased in the range of PEG concentrations previously found to cause fusion of membranes containing fusogenic amphipaths. For nonfusogenic amphipaths, the anisotropy increased monotonically with PEG concentration. The properties of similar probes that locate in the hydrophobic core of the bilayer showed no correlation with fusogenicity, nor did the properties of probes purported to sense the aqueous surface of the membrane. Second, the frequency of the C=O stretch increased and then decreased dramatically as fusogenic but not nonfusogenic membranes were heated through their phase transition. Third, there was a dramatic increase in the frequency of the C-O-C ester stretch at the membrane order/disorder phase transition for membranes containing fusogenic amphipaths, twice the increase observed for nonfusogenic amphipaths. The spectral characteristics of phosphate, choline, and acyl chain motions showed no such correlation with fusogenicity. Finally, calorimetric measurements showed that low levels of fusogenic amphipaths eliminated the "pretransition" (L beta-->P beta) in DPPC membranes, whereas other amphipaths shifted but did not eliminate this transition. Taken together, these results indicate that fusogenic amphipaths perturb the interface or "backbone" region of the bilayer rather than the hydrophobic core, the headgroup, or the water interface regions of DPPC bilayers.
Manipulation of individual viruses: friction and mechanical properties
Creators: name: Superfine, R.
name: Finch, M.
name: Washburn, S.
name: Taylor II, R. M.
name: Brooks Jr., F. P.
name: Falvo, M. R.
name: Chi, V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: We present our results on the manipulation of individual viruses using an advanced interface for atomic force microscopes (AFMs). We show that the viruses can be dissected, rotated, and translated with great facility. We interpret the behavior of tobacco mosaic virus with a mechanical model that makes explicit the competition between sample-substrate lateral friction and the flexural rigidity of the manipulated object. The manipulation behavior of tobacco mosaic virus on graphite is shown to be consistent with values of lateral friction observed on similar interfaces and the flexural rigidity expected for macromolecular assemblies. The ability to manipulate individual samples broadens the scope of possible studies by providing a means for positioning samples at specific binding sites or predefined measuring devices. The mechanical model provides a framework for interpreting quantitative measurements of virus binding and mechanical properties and for understanding the constraints on the successful, nondestructive AFM manipulation of delicate samples.
(101516) Ernest William Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Between the One and the Nine: Counting and Telling in Hamlet and The Winter’s Tale
Creators: name: Wilson, Luke
Publisher: name: Skenè. Journal of Theatre and Drama Studies
Year: 2016

description: As is suggested by the ambiguity in certain key terms (tell, tale, count, account, recount, and so on), counting and narrative are intimately associated, especially in Shakespeare. This essay considers this association in the opening of Hamlet and in a couple of scenes in The Winter’s Tale. Gaps in dramatic mimesis are often filled diegetically, an operation that is sometimes numerically inflected. Scholars have suggested that Shakespeare’s dramaturgy works by a combination of the mimetic and diegetic that points inferentially towards a wider fictional world (fabula). I argue that this operation may be understood numerically, as sometimes additive and sometimes multiplicative. Where telling gives way to showing in Hamlet 1.1, it does so as if in an attempt to start counting, initiate a movement forward that is both mimetic and diegetic. The Winter’s Tale, I propose, shows us linear and logarithmic counting set in contrast to one another, raising the possibility that these may be associated with diegesis and mimesis respectively.
description: Skenè. Journal of Theatre and Drama Studies, Vol 2 No 2 (2016): Diegesis and Mimesis
Permeation through the calcium release channel of cardiac muscle
Creators: name: Tripathy, Ashutosh
name: Meissner, Gerhard
name: Xu, Le
name: Eisenberg, Bob
name: Chen, Duan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Current voltage (I-V) relations were measured from the calcium release channel (CRC) of the sarcoplasmic reticulum of cardiac muscle in 12 KCl solutions, symmetrical and asymmetrical, from 25 mM to 2 M. I-V curves are nearly linear, in the voltage range +/- 150 mV approximately 12kT/e, even in asymmetrical solutions, e.g., 2 M // 100 mM. It is awkward to describe straight lines as sums of exponentials in a wide range of solutions and potentials, and so traditional barrier models have difficulty fitting this data. Diffusion theories with constant fields predict curvilinear I-V relations, and so they are also unsatisfactory. The Poisson and Nernst-Planck equations (PNP) form a diffusion theory with variable fields. They fit the data by using adjustable parameters for the diffusion constant of each ion and for the effective density of fixed (i.e., permanent) charge P(x) along the channel's "filter" (7-A diameter, 10 A long). If P(x) is described by just one parameter, independent of x (i.e., P(x) = P0 = -4.2 M), the fits are satisfactory (RMS error/RMS current = 6.4/67), and the estimates of diffusion coefficients are reasonable D(K) = 1.3 x 10(-6) cm2/s, D(Cl) = 3.9 x 10(-6) cm2/s. The CRC seems to have a small selectivity filter with a very high density of permanent charge. This may be a design principle of channels specialized for large flux. The Appendix derives barrier models, and their prefactor, from diffusion theories (with variable fields) and argues that barrier models are poor descriptions of CRCs in particular and open channels in general.
The role of monolayer viscosity in Langmuir film hole closure dynamics
Creators: name: Jia, Leroy L.
name: Shelley, Michael J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We re-examine the model proposed by Alexander et al. (2006) for the closing of a circular hole in a molecularly thin incompressible Langmuir film situated on a Stokesian subfluid. For simplicity their model assumes that the surface phase is inviscid which leads to the result that the cavity area decreases at a constant rate determined by the ratio of edge tension to subfluid viscosity. We reformulate the problem, allowing for a regularizing monolayer viscosity. The viscosity-dependent corrections to the hole dynamics are analyzed and found to be nontrivial, even when the monolayer viscosity is small; these corrections may explain the departure of experimental data from the theoretical prediction when the hole radius becomes comparable to the Saffman-Delbruck length. Through fitting, we find the edge tension could be as much as eight times larger (~5.5 pN) than previously reported under these relaxed assumptions.
description: 7 pages, 2 figures
Supplementary analyses and figures. from The roots of polarization in the individual reward system
Creators: name: Lefebvre, Germain
name: Deroy, Ophélia
name: Bahrami, Bahador
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified
classificationCode: 310901
subject: Animal behaviour
classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: The supplementary analyses cover additional simulations performed to measure the impact of different model parameters and simulation lengths.
Sophoclean Beckett in Performance
Creators: name: Spence, Barry Allen
Publisher: name: Skenè. Journal of Theatre and Drama Studies
Year: 2016

description: While Samuel Beckett’s innovations for the stage place him in the vanguard of late twentieth-century theatre, his debt to ancient Greek drama is seldom discussed. This article argues that the richest engagement between Beckett’s theatre and the tragedy and comedy of ancient Athens can be seen in the performance, that is, postpublication phase of his plays’ composition. Beckett’s directorial control created an ongoing compositional process; using the evidence of his production notes, I demonstrate how his performative aesthetics echo what is known of Greek practice and, in particular, how he makes mimetic use of an ekphrastic diegesis, blending telling and showing in a process of visualization. The argument is illustrated through a comparative analysis of Sophocles’ Oedipus the King and the performance history of Krapp’s Last Tape. While both play texts involve a central dramatic analepsis which triggers the realization of an unwitting quasi-nostos, in performance Beckett’s play increasingly emphasizes such Sophoclean elements as a circumscribed mise en scène, restrained bodily movement, ekphrastic spectacle, and a heightened use of both extrascenic and distanced space. Underscoring these correspondences is a shared paratactic modality, in evidence at key moments on the level of the lexis (resulting in meaningful pauses and appositional juxtapositions in the dialogue) as well as in phenomenological aspects of each play’s performance.
description: Skenè. Journal of Theatre and Drama Studies, Vol 2 No 2 (2016): Diegesis and Mimesis
A vanishing theorem for the homology of discrete subgroups of $\mathrm{Sp}(n,1)$ and $\mathrm{F}_4^{-20}$
Creators: name: Connell, Chris
name: Farb, Benson
name: McReynolds, D. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Differential Geometry (math.DG)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: For any discrete, torsion-free subgroup $Γ$ of $\mathrm{Sp}(n,1)$ (resp.\ $\mathrm{F}_4^{-20}$) with no parabolic elements, we prove that $H_{4n-1}(Γ;V)=0$ (resp.\ $H_i(Γ;V)=0$ for $i=13,14,15$) for any $Γ$--module $V$. The main technical advance is a new bound on the $p$--Jacobian of the barycenter map of Besson--Courtois--Gallot. We also apply this estimate to obtain an inequality between the critical exponent and homological dimension of $Γ$, improving on work of M.~Kapovich.
description: v2. 24 pages. To appear in J. Lond. Math. Soc
Repurposing of Existing Pharmaceutical Drugs Against Monkey-pox Virus: An In Silico Study
Creators: name: Sarkar, Kaushik
name: Das, Rajesh Kumar
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Monkeypox virus (MPXV) is considered as zoonotic disease with characteristics comparable to smallpox virus. The disease is now a global epidemic concern. Currently, tecovirimat is approved by US Food and Drug Administration (FDA) for MPXV treatment. The aim of this in silico study is to repurpose approved pharmaceutical drugs as potential inhibitors of MPXV target. In this study, molecular docking was performed on 406 pharmaceutical drugs, and results were compared with reference tecovirimat. Results showed that 7 compounds, bictegravir, glimepiride, glyburide, lasmiditan, olaparib, rimegepant, and ubrogepant, have shown higher binding energies compared to the reference. After that, these best hits were further assessed by 100 ns molecular dynamics simulation and the best results were observed for bictegravir, glimepiride, glyburide, olaparib, and ubrogepant. The docking analysis was further validated by molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) binding free energy calculations. In addition, pharmacokinetics and density functional theory (DFT) studies were also discussed for these best hits. In conclusion, three compounds, bictegravir, glimepiride, and glyburide, have satisfied all the criteria for better leads against MPXV.
(101515) Edward Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Thermodynamic Analysis of a Novel Cycle for Nuclear SMR and Heat Transfer Performance Validation of the Related Supercritical Working Fluids
Creators: name: Pepper, Benjamin M.
Publisher: name: Utah State University
Year: 2022

description: Currently, all operating nuclear power facilities in the U.S. follow the same general design and process: light-water reactors boil water into steam using bundles of nuclear fuel rods as a heat source, pumping that steam through a turbine which powers a generator to produce clean year-round electricity. Water is an effective coolant, but other facilities around the world have demonstrated the ability to use non-water-based coolants in nuclear reactor designs, which consequently have their own trade-offs. Some positive consequences of using different reactor designs include enhanced safety, better economics, and cheaper clean consumer energy. The work described in this paper begins with a computer model of a nuclear reactor design that uses non-water-based coolants, both pure fluids and mixtures, and measures the performance based on a few metrics. While the model did not show that the selected mixtures worked well as coolants, some of the pure fluids did lead to reactor performance at least as good as the water-based counterpart. This motivated a physical experiment that was built to better document and understand the ability for these pure fluids to transfer heat under specific conditions. These conditions include different fluid phases such as liquid or gas, and even supercritical liquids or gases which exist at higher pressures and temperatures. The boundary between supercritical phases are less clear and the distinction between them are less definite if measured by their physical properties. The experimental setup was validated to accurately capture and measure the desired heat transfer behaviors for selected fluids. The design is also future-proofed by utilizing modularity of components and by fabricating new components for testing corrosive/reactive fluids.
Göran Lindblad in memoriam
Creators: name: Bengtsson, Ingemar
Publisher: name: arXiv
Year: 2023
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This is a brief account of the life and work of Göran Lindblad.
description: 11 pages, one picture
(101514) Herbert Cooper
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transfer of 0-order coherence matrix along spin-1/2 chain
Creators: name: Bochkin, G. A.
name: Fel'dman, E. B.
name: Lazarev, I. D.
name: Pechen, A. N.
name: Zenchuk, A. I.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work, we study transfer of coherence matrices along spin-1/2 chains of various length. Unlike higher order coherence matrices, 0-order coherence matrix can be perfectly transferred if its elements are properly fixed. In certain cases, to provide the perfect transfer, an extended receiver together with optimized its unitary transformation has to be included into the protocol. In this work, the asymptotic perfectly transferable 0-order coherence matrix for an infinitely long chain is considered and deviation of a perfectly transferred state from this asymptotic state is studied as a function of the chain length for various sizes of the extended receiver. The problem of arbitrary parameter transfer via the nondiagonal elements of the 0-order coherence matrix is also considered and optimized using the unitary transformation of the extended receiver.
description: 32 pages, 5 figures
(101513) Joseph Mortimer Granville
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101512) Mary Anne Brook [Ormerod]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Neural network reconstruction of the dense matter equation of state from neutron star observables
Creators: name: Soma, Shriya
name: Wang, Lingxiao
name: Shi, Shuzhe
name: Stöcker, Horst
name: Zhou, Kai
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The Equation of State (EoS) of strongly interacting cold and hot ultra-dense QCD matter remains a major challenge in the field of nuclear astrophysics. With the advancements in measurements of neutron star masses, radii, and tidal deformabilities, from electromagnetic and gravitational wave observations, neutron stars play an important role in constraining the ultra-dense QCD matter EoS. In this work, we present a novel method that exploits deep learning techniques to reconstruct the neutron star EoS from mass-radius (M-R) observations. We employ neural networks (NNs) to represent the EoS in a model-independent way, within the range of $\sim$1-7 times the nuclear saturation density. The unsupervised Automatic Differentiation (AD) framework is implemented to optimize the EoS, so as to yield through TOV equations, an M-R curve that best fits the observations. We demonstrate that this method works by rebuilding the EoS on mock data, i.e., mass-radius pairs derived from a randomly generated polytropic EoS. The reconstructed EoS fits the mock data with reasonable accuracy, using just 11 mock M-R pairs observations, close to the current number of actual observations.
description: 24 pages, 14 figures, https://github.com/ss-fias/nn-eos
(101511) William George Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phosphorylation-dependent power output of transgenic flies: an integrated study
Creators: name: Moore, Jeffrey R.
name: Tohtong, Rutawain
name: Simcox, Amanda
name: Lehmann, Fritz Olaf
name: Dickinson, Michael H.
name: Maughan, David W.
name: Hyatt, Christopher J.
name: Vigoreaux, Jim O.
name: Reedy, Mary C.
name: Yamashita, Hiroshi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: We examine how the structure and function of indirect flight muscle (IFM) and the entire flight system of Drosophila melanogaster are affected by phosphorylation of the myosin regulatory light chain (MLC2). This integrated study uses site-directed mutagenesis to examine the relationship between removal of the myosin light chain kinase (MLCK) phosphorylation site, in vivo function of the flight system (flight tests, wing kinematics, metabolism, power output), isolated IFM fiber mechanics, MLC2 isoform pattern, and sarcomeric ultrastructure. The MLC2 mutants exhibit graded impairment of flight ability that correlates with a reduction in both IFM and flight system power output and a reduction in the constitutive level of MLC2 phosphorylation. The MLC2 mutants have wild-type IFM sarcomere and cross-bridge structures, ruling out obvious changes in the ultrastructure as the cause of the reduced performance. We describe a viscoelastic model of cross-bridge dynamics based on sinusoidal length perturbation analysis (Nyquist plots) of skinned IFM fibers. The sinusoidal analysis suggests the high power output of Drosophila IFM required for flight results from a phosphorylation-dependent recruitment of power-generating cross-bridges rather than a change in kinetics of the power generating step. The reduction in cross-bridge number appears to affect the way mutant flies generate flight forces of sufficient magnitude to keep them airborne. In two MLC2 mutant strains that exhibit a reduced IFM power output, flies appear to compensate by lowering wingbeat frequency and by elevating wingstroke amplitude (and presumably muscle strain). This behavioral alteration is not seen in another mutant strain in which the power output and estimated number of recruited cross-bridges is similar to that of wild type.
(101510) Maria Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Creswell Volunteer Archaeology Project Insights into including Rural Community Residents in Archaeology and Heritage
Creators: name: Nelson, Theresa
name: Kuykendall, Kevin
name: Jones, Angharad
Publisher: name: Zenodo
Year: 2024

description: Creswell Heritage Trust (CHT), or Creswell Crags, is an enclosed limestone gorge on the  Derbyshire/Nottinghamshire border of England and includes caves occupied during the  last Ice Age. Located in Creswell, England, which is within the top 10% to 20% of the  most deprived areas in the country, this rural heritage site is striving to support local  communities impacted by the aftermath of mining and deindustrialisation whilst  repositioning itself as an ‘archaeological park’ inviting visitors to “walk in the footsteps of  early humans and woolly mammoths.” In 2023, the Creswell Volunteer Archaeology  Project (CVAP), a collaboration between the University of Sheffield Department of  Archaeology and CHT, successfully enacted a model of community-engaged  archaeological fieldwork to understand how to mobilise public perceptions and better  understand the role of archaeology for audience development and programming. CVAP  successfully recruited a cohort of local community residents to participate in an  excavation, implemented pre- and post-excavation interviews for participants to  understand their views before and after excavation participation, and disseminated a  public survey for community members to better understand and include views on  archaeology and Creswell Crags. At the end of the project, CVAP and its participants co produced a free museum exhibit at CHT and a local cafe, “The Community Experience:  Archaeology at the Crags,” which included a documentary created by and from the  perspective of a local Creswell resident and Seasonal Service Assistant at CHT. Our 2023  work provides insights on good practices in heritage management for other rural, cultural  tourism sites, including: interacting with socioeconomically deprived communities via  social media engagement, physical fliers, and free, in-person events outside of heritage  sites; methods of communication with local community members and heritage staff to  include their voices and perspectives; and co-producing informative museum exhibits  which are accessible both within and outside of rural heritage sites.
Passivity-Based Adaptive Control for Visually Servoed Robotic Systems
Creators: name: Wang, Hanlei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Systems and Control (eess.SY)
subject: Robotics (cs.RO)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: This paper investigates the visual servoing problem for robotic systems with uncertain kinematic, dynamic, and camera parameters. We first present the passivity properties associated with the overall kinematics of the system, and then propose two passivity-based adaptive control schemes to resolve the visual tracking problem. One scheme employs the adaptive inverse-Jacobian-like feedback, and the other employs the adaptive transpose Jacobian feedback. With the Lyapunov analysis approach, it is shown that under either of the proposed control schemes, the image-space tracking errors converge to zero without relying on the assumption of the invertibility of the estimated depth. Numerical simulations are performed to show the tracking performance of the proposed adaptive controllers.
description: 18 pages, 7 figures, revised for improving the presentation and correcting several typos based on the reviewers' and AE's comments from IEEE Transactions on Automatic Control
An exploration of consumer perceptions of sustainable wine
Creators: name: Pickering, Gary J.
name: Best, Maria
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Despite increasing interest in the category, there has been limited consumer-focused research to date around sustainable wines, especially in the Canadian context, despite the importance of consumer perceptions in driving wine purchase behaviour. In this mixed methods online survey of Canadian wine consumers (n = 725), we sought to determine how important sustainability-related cues are in purchase decisions, what beliefs and knowledge consumers possess around sustainable wines, and what are the characteristics of consumers with low and high sustainable wine involvement. Results show that sustainability-related cues are somewhat valued by consumers when making purchase decisions, but have low importance relative to the other cues examined. Environmental dimensions of sustainability have high saliency, in contrast with social and economic dimensions, and a significant minority of respondents report no or very limited knowledge of sustainable wines. Additionally, consumers with high involvement in sustainable wines tend to be younger, better educated, more involved in wine in general, and spend more per bottle than those with low involvement. Our findings support initiatives to develop global frameworks around sustainable wine and educate consumers on sustainable wine practises, as well as offer insights into marketing opportunities to promote this important product category.
Prediction of solution structures of the Ca2+-bound gamma-carboxyglutamic acid domains of protein S and homolog growth arrest specific protein 6: use of the particle mesh Ewald method
Creators: name: Li, Leping
name: Monroe, D. M.
name: Pedersen, Lee G.
name: Darden, Tom
name: Perera, Lalith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The solution structures of the N-terminal domains of protein S, a plasma vitamin K-dependent glycoprotein, and its homolog growth arrest specific protein 6 (Gas6) were predicted by molecular dynamics computer simulations. The initial structures were based on the x-ray crystallographic structure of the corresponding region of bovine prothrombin fragment 1. The subsequent molecular dynamics trajectories were calculated using the second-generation AMBER force field. The long-range electrostatic forces were evaluated by the particle mesh Ewald method. The structures that stabilized over a 400-ps time interval were compared with the corresponding region of the simulated solution structure of bovine prothrombin fragment 1. Structural properties of the gamma-carboxyglutamic acid (Gla) domains obtained from simulations and calcium binding were found to be conserved for all three proteins. Analysis of the predicted solution structure of the Gla domain of Gas6 suggests that this domain should bind with negatively charged phospholipid surfaces analogous to bovine prothrombin fragment 1 and protein S.
Analysis of high-resolution spectra from a hybrid interferometric/dispersive spectrometer
Creators: name: Ko, P.
name: Scott, J. R.
name: Jovanovic, I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: To more fully take advantage of a low-cost, small footprint hybrid interferometric/dispersive spectrometer, a mathematical reconstruction technique was developed to accurately capture the high-resolution and relative peak intensities from complex spectral patterns. A Fabry-Perot etalon was coupled to a Czerny-Turner spectrometer, leading to increased spectral resolution by more than an order of magnitude without the commensurate increase in spectrometer size. Measurement of the industry standard Hg 313.1555/313.1844 nm doublet yielded a ratio of 0.682, which agreed well with an independent measurement and literature values. The doublet separation (29 pm) is similar to the U isotope shift (25 pm) at 424.437 nm that is of interest to monitoring nuclear nonproliferation activities. Additionally, the technique was applied to LIBS measurement of the mineral cinnabar (HgS) and resulted in a ratio of 0.682. This reconstruction method could enable significantly smaller, portable high-resolution instruments with isotopic specificity, benefiting a variety of spectroscopic applications.
description: Accepted to Optics Communications
A Composite Medical Image Optimization Scheme Using Honey Encryption and Ant-Lion Algorithms for Secured Diagnostic Systems
Creators: name: T, Jarin
Publisher: name: figshare
Year: 2023
Subjects: Electrical engineering not elsewhere classified
Biomedical instrumentation

description: Medical imaging technology is one of the most critical applications necessitating data protection, particularly if we need to keep track of any important patient information. This medical imaging system employs encryption and decryption. Using several cryptographic techniques, the security key was established to protect the data. Every network that sends and receives data needs to be secure in some way. In this paper, ALO along with the encryption algorithm honey is used to enhance the security of medical imaging technologies, the proposed study uses a variety of ways to protect important health information. In comparison to the existing one, the proposed honey algorithm attains better results. Further, the antlion optimizer uses random keys throughout the encryption and decryption. In the next step, the keys are remodeled using antlion optimization. After that, the updated key is optimized by analyzing every element and generating paths that trigger the traps and latching functions. The mean square error (MSE) is reduced to 1% and the peak signal-to-noise ratio (PSNR) is increased to 98% by using a hybrid strategy.
(101509) Walter Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interplay of itinerant electrons and Ising moments in a hybrid honeycomb quantum magnet TmNi$_3$Al$_9$
Creators: name: Ge, H.
name: Huang, C. J.
name: Zhang, Q.
name: Zhao, N.
name: Wang, L.
name: Yang, J.
name: Fu, Y.
name: Zhang, L.
name: Song, Z. M.
name: Li, T. T.
name: Ding, F.
name: Xu, J. B.
name: Zhang, Y. F.
name: Tong, X.
name: Wang, S. M.
name: Mei, J. W.
name: Podlesnyak, A.
name: Wu, L. S.
name: Chen, Gang
name: Sheng, J. M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The interplay between itinerant electrons and local magnetic moments in quantum materials brings about rich and fascinating phenomena and stimulates various developments in the theoretical framework. In this work, thermodynamic, electric transport, and neutron diffraction measurements were performed on a newly synthesized honeycomb lattice magnet TmNi$_3$Al$_9$. Based on the experimental data, a magnetic field temperature phase diagram was constructed, exhibiting three essentially different magnetic regions. Below ${T_{\rm N}=2.97 \pm 0.02}\ \rm K$ Tm$^{3+}$ moments order antiferromagnetically in zero field. We found that the Tm$^{3+}$ ions form a pseudo-doublet ground state with the Ising-like moments lying normal to the two-dimensional honeycomb layers. Application of a magnetic field along the easy axis gradually suppresses the antiferromagnetic order in favor of an induced ferromagnetic state above the critical field ${B_c=0.92 \pm 0.05}\ \rm T$. In the vicinity of $B_c$, a strong enhancement of the quantum spin fluctuations was observed. The quantum Ising nature of the local moments and the coupling to itinerant electrons are discussed.
description: 9 pages, 9 figures
Roles of factor Va heavy and light chains in protein and lipid rearrangements associated with the formation of a bovine factor Va-membrane complex
Creators: name: Koppaka, Vishwanath
name: Zhai, Xin
name: Lentz, Barry R.
name: Talbot, William F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Factor Va is an essential protein cofactor of the enzyme factor Xa, which activates prothrombin to thrombin during blood coagulation. Peptides with an apparent Mr of approximately 94,000 (heavy chain; HC) and approximately 74,000 or 72,000 (light chain; LC) interact in the presence of Ca2+ to form active Va. The two forms of Va-LC differ in their carboxyl-terminal C2 domain. Using Va reconstituted with either LC form, we examined the effects of the two LC species on membrane binding and on the activity of membrane-bound Va. We found that 1) Va composed of the 72,000 LC bound only slightly more tightly to membranes composed of a mixture of neutral and acidic lipids, the Kd being reduced by a factor of approximately 3 at 5 mM and by a factor of 6 at 2 mM Ca2+. 2) The two forms of Va seemed to undergo different conformational changes when bound to a membrane. 3) The activity of bovine Va varied somewhat with LC species, the difference being greatest at limiting Xa concentration. We have also addressed the role of the two Va peptides in membrane lipid rearrangements and binding: 1) Va binding increased lateral packing density in mixed neutral/acidic lipid membranes. In the solid phase, Va-HC had no effect, whereas Va-LC and whole Va had similar but small effects. In the fluid phase, Va-HC and whole Va both altered membrane packing, with Va-HC having the largest effect. 2) Va-HC bound reversibly and in a Ca2+-independent fashion to membranes composed of neutral phospholipid (Kd, approximately 0.3 microM; stoichiometry approximately 91). High ionic strength had little effect on binding. 3) The substantial effect of Va on packing within neutral phospholipid membranes was mimicked by Va-HC. 4) Based on measurements of membrane phase behavior, binding of Va or its peptide components did not induce thermodynamically discernible lateral membrane domains. These results suggest that the membrane association of factor Va is a complex process involving both chains of Va, changes in lipid packing, and changes in protein structure.
SIMS: computation of a smooth invariant molecular surface
Creators: name: Hermans, Jan
name: Vorobjev, Yury N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: SIMS, a new method of calculating a smooth invariant molecular dot surface, is presented. The SIMS method generates the smooth molecular surface by rolling two probe spheres. A solvent probe sphere is rolled over the molecule and produces a Richards-Connolly molecular surface (MS), which envelops the solvent-excluded volume of the molecule. In deep crevices, Connolly's method of calculating the MS has two deficiencies. First, it produces self-intersecting parts of the molecular surface, which must be removed to obtain the correct MS. Second, the correct MS is not smooth, i.e., the direction of the normal vector of the MS is not continuous, and some points of the MS are singular. We present an exact method for removing self-intersecting parts and smoothing the singular regions of the MS. The singular MS is smoothed by rolling a smoothing probe sphere over the inward side of the singular MS. The MS in the vicinity of singularities is replaced with the reentrant surface of the smoothing probe sphere. The smoothing method does not disturb the topology of a singular MS, and the smooth MS is a better approximation of the dielectric border between high dielectric solvent and the low dielectric molecular interior. The SIMS method generates a smooth molecular dot surface, which has a quasi-uniform dot distribution in two orthogonal directions on the molecular surface, which is invariant with molecular rotation and stable under changes in the molecular conformation, and which can be used in a variety of implicit methods of modeling solvent effects. The SIMS program is faster than the Connolly MS program, and in a matter of seconds generates a smooth dot MS of a 200-residue protein. The program is available from the authors on request (see http:@femto.med.unc.edu/SIMS).
Velocity autocorrelation in liquid para-hydrogen by quantum simulations for first-principle computations of the neutron cross sections
Creators: name: Guarini, E.
name: Neumann, M.
name: Bafile, U.
name: Celli, M.
name: Colognesi, D.
name: Farhi, E.
name: Calzavara, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Accurate knowledge of the single-molecule (self) translational dynamics of liquid para-H2 is an essential requirement for the calculation of the neutron scattering properties of this important quantum liquid. We show that, by using Centroid Molecular Dynamics (CMD) quantum simulations of the velocity autocorrelation function, calculations of the total neutron cross section (TCS) remarkably agree with experimental data at the thermal and epithermal incident neutron energies where para-H2 dynamics is actually dominated by the self contributions. This result shows that a proper account of the quantum nature of the fluid, as provided by CMD, is a necessary and very effective condition to obtain the correct absolute-scale cross section values directly from first-principle computations of the double differential cross section, and without the need of introducing any empirically adjusted quantity. At subthermal incident energies, appropriate modeling of the para-H2 intermolecular (distinct) dynamics also becomes crucial, but quantum simulations are not yet able to cope with it. Existing simple models which account for the distinct part provide an appropriate correction of self-only calculations and bring the computed results in reasonable accord with TCS experimental data available until very recently. However, if just published cross section measurements in the cold range are considered, the agreement turns out to be by far superior and very satisfactory. The possible origin of slight residual differences will be commented and suggest further computational and experimental efforts. Nonetheless, the ability to reproduce the total cross section in the wide range between 1 and 900 meV represents an encouraging and important validation step of the CMD method and of the present simple algorithm.
Large-scale structures in the stellar wind of fast-rotating stars spawned by the presence of Earth-like planets
Creators: name: Canet, Ada
name: De Castro, Ana I. Gómez
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Forming planets around young, fast-rotating solar-like stars are exposed to an intense X-ray/extreme ultraviolet radiation field and strongly magnetized stellar winds, as a consequence of the high magnetic activity of these stars. Under these conditions, Earth-like exoplanets may experience a rapid loss of their primordial hydrogen atmospheres, resulting in atmosphere-less rocky obstacles for the stellar winds. The interaction of stellar winds with those planets leads to the formation of potentially observable structures due to the formation of large-scale magnetic field and density disturbances in the vicinity of these planets, such as bow shocks, induced magnetospheres and comet-like tails. In this work, we study the interaction between the stellar winds of active, fast-rotating solar-like stars in the superfast-magnetosonic regime with Earth-like, unmagnetized, tenuous atmosphere, planetary obstacles through numerical 3D simulations using the PLUTO magnetohydrodynamical code. The properties of AB Doradus, a nearby young star with a small rotation period (0.51 days) and a strong flaring activity, have been used to parameterize this early wind state. Bow shock and induced magnetosphere formation are characterized through the alfvénic Mach number MA of the wind, for different stellar wind configurations. Large bow shocks, up to an extension of ~7.0 planetary radii are found for low-MA winds. The general increase of density, temperature and magnetic field in these large-scale structures formed around planets may result in potentially detectable spectral signatures.
(101508) Sarah Ann Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.