cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fächerübergreifender Unterricht im Fächerverbund Naturwissenschaften und Sport
Creators: name: Kramer, Niklas
name: Wegner, Claas
Publisher: name: Herausforderung Lehrer*innenbildung - Zeitschrift zur Konzeption, Gestaltung und Diskussion
Year: 2020

description: Fächerübergreifender Unterricht wird bereits seit vielen Jahren theoretisch hinsichtlich möglicher Potenziale und einer Implementierung an Schulen diskutiert. Stellenweise werden Formen fächerübergreifenden Unterrichts bereits umgesetzt. Gerade eine Fächerkombination von Sport mit einem oder mehreren der naturwissenschaftlichen Fächer scheint sich als ergiebig und wünschenswert herauszustellen, da viele konzeptionelle Ideen existieren, die in diesen Arbeiten allerdings nur selten evaluiert werden. Inwiefern diese Fachkombination schon empirisch beforscht wurde und wo weitere Forschungsdesiderate liegen, soll die vorliegende Arbeit klären. Hierfür erfolgt nach einer theoretischen Einordnung des Forschungsgegenstands die Darstellung einer systematischen Literaturrecherche zu empirischen Befunden von fächerübergreifenden Unterrichtsvorhaben, die sich mit sportlichen und naturwissenschaftlichen Inhalten befassen. Dabei konnten über das Fachportal Pädagogik in dem Suchzeitraum der Jahre von 2000 bis 2019 insgesamt 14 Studien erfasst werden, von denen sich zehn Studien vorrangig mit dem Wissenszuwachs beschäftigten. Es konnte herausgestellt werden, dass fächerübergreifende Interventionen zu einem erhöhten Wissenszuwachs führen. Dies ist allerdings durch die konzeptionelle Nähe zum „Bewegten Lernen“ kritisch zu betrachten, da dort ähnliche Testergebnisse gefunden werden. Darüber hinaus werden kleinere positive Befunde für den affektiv-motivationalen Bereich und bei sportpraktischen Untersuchungen berichtet, wobei bei letzteren durchaus kontrastierende Ergebnisse vorliegen. Insgesamt zeigt sich das Forschungsfeld dennoch sehr eindimensional. Dies hat die Forderung nach diverseren und größeren Forschungsvorhaben zur Folge, um fächerübergreifenden Unterricht didaktisch weiter legitimieren und vermehrt umsetzen zu können.
description: Herausforderung Lehrer*innenbildung - Zeitschrift zur Konzeption, Gestaltung und Diskussion, Bd. 3 Nr. 1 (2020): Herausforderung Lehrer_innenbildung - Ausgabe 3
Treatment Recommendations for Locally Advanced, Non-Small-Cell Lung Cancer: The Influence of Physician and Patient Factors
Creators: name: Lee, Irwin H.
name: Goodman, Karyn A.
name: Hayman, James A.
name: Landrum, Mary Beth
name: Tepper, Joel
name: Keating, Nancy L.
name: Tao, May Lin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To determine the impact of patient age, comorbidity, and physician factors on treatment recommendations for locally-advanced, unresectable non-small cell lung cancer (NSCLC).
Imaging for Assessment of Radiation-Induced Normal Tissue Effects
Creators: name: Cao, Yue
name: Ten Haken, Randall K.
name: Jeraj, Robert
name: Hahn, Carol
name: Marks, Lawrence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing re-optimization of treatment strategies based upon individual patients’ risks and benefits. Early detection with non-invasive imaging may enable interventions to mitigate therapy-associated injury prior to its clinical manifestation. Further, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials where normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.
title: Übersetzung in Arabisch: Koronare Herzkrankheit. Koronare Herzkrankheit - Verhalten im Notfall.
Creators: name: Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ)
Publisher: name: Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Ärztliches Zentrum für Qualität in der Medizin (ÄZQ)
Year: 2011
Subjects: subject: 610 Medical sciences; Medicine

description: Kurzinformation für Patienten
The Use of Libraries in the Italian Regions in the Period 2019-2022
Creators: name: Leogrande, Angelo
Publisher: name: Zenodo
Year: 2023

description: Istat calculates the use of libraries. Use of libraries is calculated as the percentage of people aged 3 years and older who went to the library at least once in the 12 months preceding the interview out of the total number of people aged 3 years and older. The data refers to the period between 2019 and 2022 for the Italian regions and macro-regions.
Impact of High-Dose Chemotherapy on the Ability to Deliver Subsequent Local–Regional Radiotherapy for Breast Cancer: Analysis of Cancer and Leukemia Group B Protocol 9082
Creators: name: Shpall, Elizabeth J.
name: Fitzgerald, Thomas J.
name: Peters, William P.
name: Laurie, Frances
name: Seagren, Steven
name: Ma, Jinli
name: Glicksman, Arvin S.
name: Peterson, Bercedis L.
name: Crump, Michael
name: Prosnitz, Leonard R.
name: Hurd, David D.
name: Henderson, I. Craig
name: Richardson, Paul G.
name: Cirrincione, Constance
name: Norton, Larry
name: Vredenburgh, James
name: Schuster, Michael W.
name: Marks, Lawrence B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To report, from Cancer and Leukemia Group B Protocol 9082, the impact of high-dose cyclophosphamide, cisplatin, and BCNU (HD-CPB) vs. intermediate-dose CPB (ID-CPB) on the ability to start and complete the planned course of local–regional radiotherapy (RT) for women with breast cancer involving ≥10 axillary nodes.
Improving Normal Tissue Complication Probability Models: The Need to Adopt a “Data-Pooling” Culture
Creators: name: Marks, Lawrence B.
name: Bentzen, Søren M.
name: Jackson, Andrew
name: Constine, Louis S.
name: Ten Haken, Randall K.
name: Yorke, Ellen D.
name: Sharma, Ashish
name: Deasy, Joseph O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health information, to identify relevant sources of data for further analysis. After obtaining institutional approvals, data could then be pooled, greatly enhancing the capability to construct predictive models that are more widely applicable and better powered to accurately identify key predictive factors (whether dosimetric, image-based, clinical, socioeconomic, or biological). Data pooling has already been carried out effectively in a few normal tissue complication probability studies and should become a common strategy.
Lapatinib in Combination With Radiation Diminishes Tumor Regrowth in HER2+ and Basal-Like/EGFR+ Breast Tumor Xenografts
Creators: name: Camp, J. Terese
name: Shields, Janiel M.
name: Peters, Eldon
name: Livasy, Chad A.
name: Sartor, Carolyn I.
name: Kimple, Randall J.
name: Sambade, Maria J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To determine whether lapatinib, a dual epidermal growth factor receptor (EGFR)/HER2 kinase inhibitor, can radiosensitize EGFR+ or HER2+ breast cancer xenografts.
Radiation Dose–Volume Effects and the Penile Bulb
Creators: name: Deasy, Joseph O.
name: Roach, Mack
name: Nam, Jiho
name: Gagliardi, Giovanna
name: El Naqa, Issam
name: Marks, Lawrence B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The dose, volume, and clinical outcome data for penile bulb are reviewed for patients treated with external-beam radiotherapy. Most, but not all, studies find an association between impotence and dosimetric parameters (e.g., threshold doses) and clinical factors (e.g., age, comorbid diseases). According to the data available, it is prudent to keep the mean dose to 95% of the penile bulb volume to <50 Gy. It may also be prudent to limit the D70 and D90 to 70 Gy and 50 Gy, respectively, but coverage of the planning target volume should not be compromised. It is acknowledged that the penile bulb may not be the critical component of the erectile apparatus, but it seems to be a surrogate for yet to be determined structure(s) critical for erectile function for at least some techniques.
Radiation Dose–Volume Effects in the Brain
Creators: name: el Naqa, Issam
name: Dicker, Adam P.
name: Merchant, Thomas E.
name: Marks, Lawrence B.
name: Lawrence, Yaacov Richard
name: Hahn, Carol A.
name: Li, X. Allen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We have reviewed the published data regarding radiotherapy (RT)-induced brain injury. Radiation necrosis appears a median of 1–2 years after RT; however, cognitive decline develops over many years. The incidence and severity is dose and volume dependent and can also be increased by chemotherapy, age, diabetes, and spatial factors. For fractionated RT with a fraction size of <2.5 Gy, an incidence of radiation necrosis of 5% and 10% is predicted to occur at a biologically effective dose of 120 Gy (range, 100–140) and 150 Gy (range, 140–170), respectively. For twice-daily fractionation, a steep increase in toxicity appears to occur when the biologically effective dose is >80 Gy. For large fraction sizes (≥2.5 Gy), the incidence and severity of toxicity is unpredictable. For single fraction radiosurgery, a clear correlation has been demonstrated between the target size and the risk of adverse events. Substantial variation among different centers’ reported outcomes have prevented us from making toxicity–risk predictions. Cognitive dysfunction in children is largely seen for whole brain doses of ≥18 Gy. No substantial evidence has shown that RT induces irreversible cognitive decline in adults within 4 years of RT.
title: Герметизм и алхимия: проект «Дмитрий Александрович Пригов»
Creators: name: Бравин, Аличе
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Доклад посвящен исследованию герметических и алхимических мотивов в творчестве Дмитрия Пригова. Среди разных традиций, которые перекликаются в его творчестве, важную роль играет герметическая культура, а среди герметических наук наиболее значительное место занимает алхимия. В статье приводятся конкретные примеры из литературных и визуальных произведений Пригова, так же как и из теоретических выступлений и интервью, и обсуждается вопрос о том, как художник обрабатывает не столько образы и мотивы алхимической традиции, сколько ее основные принципы: соотношение микрокосма и макрокосма; система аналогий и соответствий; преодоление дуализма. В результате, предлагается рассмотреть приговское концептуальное творчество как своего рода алхимический проект, который соответствует потребностям восстановления культуры и преобразования самого художника. В роли современного ренессансного мага Пригов стремится соединить и направить все знания, философии, науки и языки в единый проект — в синкретический проект ДАП, который предлагает реформацию культуры и создание искусства на новых основаниях.
title: Success in Diversity: Culture, Knowledge and Learning in Ethnically Diverse Classrooms
Creators: name: Conteh, Jean
Publisher: name: Goldsmiths, University of London
Year: 2000

description: The thesis is a longitudinal, critical ethnographic study of interaction in ethnically diverse classrooms. It tracks the mainstream school experiences of a small group of successful bilingual learners from Year 3 to Year 6. It examines the structural and contextual factors which influence children’s success in learning. A model of concentric layers of interaction is proposed to illustrate the children's intersecting experiences in school, home and community. Analysis of chosen samples of teacher- teacher, teacher-child and child-child talk in classrooms using a critical discourse framework indicates the importance of talk for children's learning, and the need for models of language and learning to underpin pedagogies which reflect the complexities of the children's experience. A key element of the theoretical stance and methodology is the attempt to valorise the viewpoints of all participants in the classroom and other contexts. The use of semi-structured interviews and other forms of data collection elicited evidence of these from the children's teachers and their parents in home contexts. These are analysed using the same frameworks as those suggested above. The findings are positioned in the historical and political contexts from which they arise and to which they contribute. The contradictions and tensions inherent in the various contexts are thus revealed. The study reveals a very complex picture of interaction in ethnically diverse classrooms with children and teachers involved in mutual negotiation and culture-creating to construct curriculum knowledge, as well as what it means to be a pupil. The conclusions of the thesis argue for the urgent need to take such evidence into account when developing policy and curricula for primary children's learning and the education of teachers. It questions the adequacy of current centrally developed models to prepare both teachers and learners to become full participants in a genuinely diverse, multicultural society.
Radiation Dose-Volume Effects in the Esophagus
Creators: name: Werner-Wasik, Maria
name: Marks, Lawrence B.
name: Deasy, Joseph
name: Yorke, Ellen
name: Nam, Jiho
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Publications relating esophageal radiation toxicity to clinical variables and to quantitative dose and dose–volume measures derived from three-dimensional conformal radiotherapy for non–small-cell lung cancer are reviewed. A variety of clinical and dosimetric parameters have been associated with acute and late toxicity. Suggestions for future studies are presented.
Radiation Dose–Volume Effects in the Lung
Creators: name: Lebesque, Joos V.
name: Timmerman, Robert D.
name: Jackson, Andrew
name: Marks, Lawrence B.
name: Vogelius, Ivan S.
name: Bradley, Jeffrey D.
name: El Naqa, Issam
name: Bentzen, Soren M.
name: Martel, Mary K.
name: Hubbs, Jessica L.
name: Deasy, Joseph O.
name: Kong, Feng-Ming (Spring)
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The three dimensional dose/volume/outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold “tolerance dose/volume” levels. There are strong volume and fractionation effects.
Radiation Dose–Volume Effects of the Urinary Bladder
Creators: name: Shipley, William U.
name: Marks, Lawrence B.
name: Eifel, Patricia J.
name: Yorke, Ellen D.
name: Viswanathan, Akila N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: An in-depth overview of the normal-tissue radiation tolerance of the urinary bladder is presented. The most informative studies consider whole-organ irradiation. The data on partial-organ/nonuniform irradiation are suspect because the bladder motion is not accounted for, and many studies lack long enough follow-up data. Future studies are needed.
Additional file 4 of Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei
Creators: name: Ambros, Conrad L.
name: Ehrmann, Matthias A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4 Fig. S1 PCR-mediated DNA amplification, verifying circularization of both prophages (TMW 1.46 P1 and TMW 1.46 P2) within a non-induced cryo stock of L. sakei TMW 1.46, visualised by agarose gel electrophoresis. “1” + “7”: GeneRuler 1 kb DNA Ladder (Thermo Scientific). “2”: TMW 1.46 P1 circularization. “3”: Negative control for “2” (water instead of a washed cryo culture). “4”: Empty. “5”: TMW 1.46 P2 circularization. “6”: Negative control for “5” (water instead of a washed cryo culture).
Efficient Model Based Diagnosis
Creators: name: Roos, Nico
Publisher: name: arXiv
Year: 2022
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.4; I.2.8
subject: 68T20, 68T30

description: In this paper an efficient model based diagnostic process is described for systems whose components possess a causal relation between their inputs and their outputs. In this diagnostic process, firstly, a set of focuses on likely broken components is determined. Secondly, for each focus the most informative probing point within the focus can be determined. Both these steps of the diagnostic process have a worst case time complexity of ${\cal O}(n^2)$ where $n$ is the number of components. If the connectivity of the components is low, however, the diagnostic process shows a linear time complexity. It is also shown how the diagnostic process described can be applied in dynamic systems and systems containing loops. When diagnosing dynamic systems it is possible to choose between detecting intermitting faults or to improve the diagnostic precision by assuming non-intermittency.
Radiation-Related Heart Disease: Current Knowledge and Future Prospects
Creators: name: Trott, Klaus R.
name: Cutter, David J.
name: Shore, Roy E.
name: Constine, Louis S.
name: Boerma, Marjan
name: Darby, Sarah C.
name: Pierce, Lori J.
name: Mabuchi, Kiyohiko
name: Mettler, Fred A.
name: Yeh, Edward T.H.
name: Kodama, Kazunori
name: Marks, Lawrence B.
name: Fajardo, Luis F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The heart has traditionally been considered a radio-resistant organ that would be unaffected by cardiac doses below about 30 Gray. During the last few years, however, evidence that radiation-related heart disease can occur following lower doses has emerged from several sources. These include studies of breast cancer patients, who received mean cardiac doses of 3–17 Gray when given radiotherapy following surgery, and studies of survivors of the atomic bombings of Japan who received doses of up to 4 Gray.
Gaseous- and Condensed-Phase Activities of Some Reactive P- and N-Containing Fire Retardants in Polystyrenes
Creators: name: Tretsiakova-McNally, Svetlana
name: Baby, Aloshy
name: Joseph, Paul
name: Pospiech, Doris
name: Schierz, Eileen
name: Lederer, Albena
name: Arun, Malavika
name: Fontaine, Gaëlle
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: char formation
subject: gaseous-phase inhibition
subject: mode of action of fire retardance
subject: P- and N-containing fire retardants
subject: polystyrene
subject: reactive modification
subject: thermal decomposition
subject: 540

description: Polystyrene (PS) was modified by covalently binding P-, P-N- and/or N- containing fire-retardant moieties through co- or ter-polymerization reactions of styrene with diethyl(acryloyloxymethyl)phosphonate (DEAMP), diethyl-p-vinylbenzyl phosphonate (DEpVBP), acrylic acid-2-[(diethoxyphosphoryl)methylamino]ethyl ester (ADEPMAE) and maleimide (MI). In the present study, the condensed-phase and the gaseous-phase activities of the abovementioned fire retardants within the prepared co- and ter-polymers were evaluated for the first time. Pyrolysis–Gas Chromatography/Mass Spectrometry was employed to identify the volatile products formed during the thermal decomposition of the modified polymers. Benzaldehyde, α-methylstyrene, acetophenone, triethyl phosphate and styrene (monomer, dimer and trimer) were detected in the gaseous phase following the thermal cracking of fire-retardant groups and through main chain scissions. In the case of PS modified with ADEPMAE, the evolution of pyrolysis gases was suppressed by possible inhibitory actions of triethyl phosphate in the gaseous phase. The reactive modification of PS by simultaneously incorporating P- (DEAMP or DEpVBP) and N- (MI) monomeric units, in the chains of ter-polymers, resulted in a predominantly condensed-phase mode of action owing to synergistic P and N interactions. The solid-state 31P NMR spectroscopy, Scanning Electron Microscopy/Energy Dispersive Spectroscopy, Inductively-Coupled Plasma/Optical Emission Spectroscopy and X-ray Photoelectron Spectroscopy of char residues, obtained from ter-polymers, confirmed the retention of the phosphorus species in their structures.
Radiotherapy Dose–Volume Effects on Salivary Gland Function
Creators: name: Chao, K.S. Clifford
name: Nam, Jiho
name: Moiseenko, Vitali
name: Eisbruch, Avraham
name: Deasy, Joseph O.
name: Marks, Lawrence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time. Severe xerostomia (defined as long-term salivary function of <25% of baseline) is usually avoided if at least one parotid gland is spared to a mean dose of less than ≈20 Gy or if both glands are spared to less than ≈25 Gy (mean dose). For complex, partial-volume RT patterns (e.g., intensity-modulated radiotherapy), each parotid mean dose should be kept as low as possible, consistent with the desired clinical target volume coverage. A lower parotid mean dose usually results in better function. Submandibular gland sparing also significantly decreases the risk of xerostomia. The currently available predictive models are imprecise, and additional study is required to identify more accurate models of xerostomia risk.
E-RIHS PP D2.2 Quality Manual and KPIs
Creators: name: Mimoso, João-Manuel
name: Miliani, Costanza
name: Van't Hof, Jan
name: Niccolucci, Franco
name: Pezzati, Luca
name: De Clercq, Hilde
Publisher: name: Zenodo
Year: 2020
Subjects: KPI
Quality

description: The future E-RIHS ERIC was designed to have Quality as one of its main pillars. To ensure its high level throughout the partnership, quality criteria must be met by all organizations and research groups that may state a connection with E-RIHS. The deliverable describes the quality system proposed to be adopted by E-RIHS for the quality assessment of prospective new partners and their services and for the quality audit of existing E- RIHS partners and their services. It also outlines the process to grant external organizations, services, projects and proposals the affiliation to E-RIHS, or its support. All such procedures are based on a modular operation: the evaluation of the candidate’s internal processes, of its scientific excellence and of the quality of its services and eventual suitability for E-RIHS. The deliverable is organized in separate documents appended to the main document which includes the principles of quality assessment. The appended documents treat the assessment methodology of technical resources and digital contributions to the common database, a basic quality manual for its partners, a common KPI system, and guidelines on Ethics to be implemented throughout the partnership. The deliverable constitutes a fundamental contribution to the design of the future ERIC. It was written by the E-RIHS PP Task 2.3 Quality systems and KPIs leader in cooperation with colleagues and made available for over 90 days before submission in the Project site on D4Science for comments by all E-RIHS PP partners.
Ras-Related Small GTPases RalA and RalB Regulate Cellular Survival After Ionizing Radiation
Creators: name: Martin, Timothy D.
name: Der, Channing J.
name: Cox, Adrienne D.
name: Kidd, Ambrose R.
name: Snider, Jared L.
name: Graboski, Sarah F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Oncogenic activation of Ras renders cancer cells resistant to ionizing radiation (IR), but the mechanisms have not been fully characterized. The Ras-like small GTPases, RalA and RalB, are downstream effectors of Ras function and are critical for both tumor growth and survival. The Ral effector RalBP1/RLIP76 mediates survival of mice after whole body irradiation but the role of the Ral GTPases themselves in response to IR is unknown. We have investigated the role of RalA and RalB in cellular responses to IR.
The Lessons of QUANTEC: Recommendations for Reporting and Gathering Data on Dose–Volume Dependencies of Treatment Outcome
Creators: name: Bentzen, Søren M.
name: Eisbruch, Avraham
name: Deasy, Joseph O.
name: Constine, Louis S.
name: Yorke, Ellen D.
name: Jackson, Andrew
name: Marks, Lawrence B.
name: Ten Haken, Randal K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The 16 clinical articles in this issue review the dose volume dependence of toxicities of external beam radiotherapy. They are limited by the difficulty of synthesizing results from different publications. The major problems stem from incomplete reporting of results and use of incompatible or ambiguous endpoints. Here we specify these problems, give recommendations to authors, editors, and reviewers on standards of reporting, and, provide methods of defining endpoints suitable for the dose-volume analysis of toxicity. Adopting these recommendations will facilitate meta-analysis and increase the utility of individual studies of the dependence of complications on dose distributions.
Comparison of bacteria in different metabolic states by micro-Raman spectroscopy
Creators: name: Shen, Haodong
name: Rösch, Petra
name: Thieme, Lara
name: Pletz, Mathias W.
name: Popp, Jürgen
Publisher: name: New York, NY [u.a.] : Elsevier
Year: 2022
Subjects: subject: Biofilm
subject: Metabolic states
subject: Micro-Raman spectroscopy
subject: Planktonic
subject: 540

description: It was shown that several metabolic states of bacteria with various characteristics such as chemical composition participate in the formation of biofilms. To study the connections and differences among different bacterial metabolic states, five species of bacteria in exponential phase, stationary phase and biofilm have been compared and investigated by micro-Raman spectroscopy. The spectral differences between different metabolic states showed that the chemical composition varied among those metabolic states. Moreover, as can be shown by the spectral differences and principal components (PCs), different species and strains of bacteria behave differently. Furthermore, a principal component analysis (PCA) combined with support vector machines (SVM) was applied to distinguish species of bacteria within the same metabolic states. Our study provides valuable data for the comparison of bacteria between different metabolic states utilizing micro-Raman spectroscopy in combination with chemometrics models.
Additional file 5 of Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei
Creators: name: Ambros, Conrad L.
name: Ehrmann, Matthias A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5 Fig. S2 PCR-mediated DNA amplification, verifying the presence of virions originating from both prophages (TMW 1.46 P1 and TMW 1.46 P2) in post UV light induced, sterile filtered and DNase I digested lysates of L. sakei TMW 1.46, visualised by agarose gel electrophoresis. “1” + “11”: GeneRuler 1 kb DNA Ladder (Thermo Scientific). “2”: Post UV light induced, DNase I treated lysate amplificated with TMW 1.46 P1 marker. “3”: Washed L. s. TMW 1.46 cryo stock amplificated with TMW 1.46 P1 marker. “4”: Negative control for “2” + “3” (water instead of a washed cryo culture). “5”: Post UV light induced, DNase I treated lysate amplificated with TMW 1.46 P2 marker. “6”: Washed L. s. TMW 1.46 cryo stock amplificated with TMW 1.46 P2 marker. “7”: Negative control for “5” + “6” (water instead of a washed cryo culture). “8”: Post UV light induced, DNase I treated lysate amplificated with 16 s rDNA marker. “9”: Washed L. s. TMW 1.46 cryo stock amplificated with 16 s rDNA marker. “10”: Negative control for “8” + “9” (water instead of a washed.
Single Fluid vs. Multifluid: Comparison between single fluid and multifluid dust models for disc planet interactions
Creators: name: Chan, Kevin
name: Paardekooper, Sijme-Jan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Recent observations of substructures such as dust gaps and dust rings in protoplanetary discs have highlighted the importance of including dust into purely gaseous disc models. At the same time, computational difficulties arise with the standard models of simulating the dust and gas separately. These include the cost of accurately simulating the interactions between well coupled dust and gas and issues of dust concentration in areas below resolution of the gas phase. We test a single fluid approach, that incorporates the terminal velocity approximation valid for small particles, which can overcome these difficulties, through modification of FARGO3D. We compare this single fluid model with a multifluid model for a variety of planet masses. We find differences in the dust density distribution in all cases. For high-mass, gap-opening planets we find differences in the amplitude of the resulting dust rings, which we attribute to the failure of the terminal velocity approximation around shocks. For low-mass planets, both models agree everywhere except in the corotation region, where the terminal velocity approximation shows overdense dust lobes. We tentatively interpret these as dusty equivalents of thermal lobes seen in non-isothermal simulations with thermal diffusion, but more work is necessary to confirm this. At the same resolution, the computational time for the terminal velocity approximation model is significantly less than a two fluid model. We conclude that the terminal velocity approximation is a valuable tool for modelling a protoplanetary disc but that care should be taken when shocks are involved.
description: 16 pages, 17 figures, 1 table
The Use of Normal Tissue Complication Probability (NTCP) Models in the Clinic
Creators: name: Constine, Louis S.
name: Nam, Jiho
name: Ten Haken, Randall K.
name: Eisbruch, Avraham
name: Yorke, Ellen D.
name: Deasy, Joseph O.
name: Jackson, Andrew
name: Bentzen, Søren M.
name: Marks, Lawrence B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The QUANTEC (quantitative analysis of normal tissue effects in the clinic) review summarizes the currently-available three dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic “Emami” paper (IJROBP 21:109, 1991). A “clinician’s view” on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly-used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.
Cosmetic Outcomes for Accelerated Partial Breast Irradiation Prior to Surgical Excision of Early Stage Breast Cancer Using Single Dose Intraoperative Radiotherapy
Creators: name: Kimple, Randall J.
name: Lian, Jun
name: Livasy, Chad A.
name: Sartor, Carolyn I.
name: Kuzmiak, Cherie M.
name: Moore, Dominic T.
name: Pavic, Dag
name: Ollila, David W.
name: Klauber-DeMore, Nancy
name: Esler, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Determine cosmetic outcome and toxicity profile of intraoperative radiation delivered prior-to tumor excision for patients with early stage breast cancer.
title: Psychische Belastung und Beanspruchung im Auslandseinsatz - Expatriates in der Entwicklungszusammenarbeit
Creators: name: Unden, Marita
Publisher: name: UNSPECIFIED
Year: 2020

description: Psychische Belastung und Beanspruchung am Arbeitsplatz stellt in verschiedenen Bereichen eine Herausforderung dar. Besonders betroffen sind hiervon soziale Berufe, aber auch Beschäftigte, die in besonders sicherheitskritischen Bereichen tätig sind wie beispielsweise Rettungskräfte, Polizistinnen und Polizisten oder Pilotinnen und Piloten. Neben den individuellen Auswirkungen für die Beschäftigten, sind die relevanten wirtschaftlichen Folgen für Organisationen zu beachten, die durch Fehlleistungen, erhöhte Krankenstände oder Fluktuation entstehen können. Dieses Forschungsvorhaben untersucht Faktoren, die die Entstehung psychischer Belastung und Beanspruchung beeinflussen. Die Analyse von Schutz- und Risikofaktoren hat zum Ziel, geeignete Arbeits- und Organisationsgestaltungsmaßnahmen zu ermöglichen. Als prägnantes Beispiel wurde der Arbeitskontext in der Entwicklungszusammenarbeit (EZ) gewählt, der durch Arbeits- und Lebensbedingungen in fragilen und von Gewalt geprägten Gesellschaften besondere Herausforderungen an die Fachkräfte stellt. Gleichzeitig ist in den letzten Jahren ein Anstieg der Einsätze von Fachkräften in Krisengebieten zu verzeichnen. Um diesen zunehmenden Herausforderungen zu begegnen, sind Unternehmen auf die Gesunderhaltung ihrer Fachkräfte angewiesen. Ein systematisches Literaturreview führt in den aktuellen Stand der Forschung zum Thema psychische Belastung und Beanspruchung bei Expatriates ein. Anschließend gibt eine Fragebogenstudie zur psychischen Gesundheit von rückkehrenden Auslandsfachkräften der Deutschen Gesellschaft für Internationale Zusammenarbeit (GIZ) Aufschluss über die Ausprägung der psychischen Belastung und Beanspruchung dieser Personengruppe. Eine Interviewstudie mit ehemaligen Auslandsfachkräften ermöglicht Einblicke in das individuelle Belastungs- und Beanspruchungsempfinden der Beschäftigten. Sie zeigt persönliche Ressourcen im Umgang mit Stress auf und gibt Hinweise auf Schutz- und Risikofaktoren für Fehlbelastung. Abschließend werden Maßnahmen zur effektiven Personalbegleitung diskutiert, die geeignet sind, Mitarbeiter vor arbeitsbedingter Fehlbelastung zu schützen und Unterstützung in Risikosituationen gewährleisten können.
NF-κB is activated by radiotherapy and is prognostic for overall survival in patients with rectal cancer treated with preoperative fluorouracil-based chemoradiation
Creators: name: Meyers, Michael O.
name: Bernard, Stephen A.
name: Funkhouser, William K.
name: O'Neil, Bert H.
name: Tepper, Joel E.
name: Caskey, Laura
name: Wright, Fred
name: Kim, Hong Jin
name: Baldwin, Albert S.
name: Calvo, Benjamin F.
name: Deal, Allison M.
name: Goldberg, Richard M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Rectal cancer is often clinically resistant to radiotherapy and there would be value to identifying molecular markers to define the biological basis for this phenomenon. NF-κB is a potentially anti-apoptotic transcription factor that has been associated with resistance to radiotherapy in model systems. This study was designed to evaluate NF- κB activation in rectal cancers being treated with chemoradiation to determine whether NF- κB activity correlates with outcome in rectal cancer
title: О поэзии Василия Бородина. Библиографический обзор
Creators: name: Гардзонио, Стефано
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В данной статье кратко описано поэтическое наследие недавно погибшего поэта Василия Бородина (1982—2021), и предложен библиографический обзор критических работ о его творчестве. На основе самых интересных высказываний критики о его поэтических книгах и о специфической природе его литературного таланта выявлены самые значимые ориентиры его поэтики, где синкретизм художественных форм выражения соотносен с особым вниманием на исполнительский план текста. Приводятся также данные о литературной генеалогии поэта и зависимости его от поэтики русского неомодернизма, русского авангарда, фольклора и некоторых представителей современной русской поэзии. Особое внимание обращено на неоднозначную интерпретацию поэтического наследия В.Бородина у разных критиков, что и обусловлено некоторой непредсказуемостью поэтического дискурса поэта и характером его самопрезентации.
Preclinical and Pilot Clinical Studies of Docetaxel Chemoradiation for Stage III Non–Small-Cell Lung Cancer
Creators: name: Keng, Peter C.
name: Pandya, Kishan J.
name: Smith, Brian
name: Chen, Yuhchyau
name: Hyrien, Ollivier
name: Feins, Richard H.
name: Smudzin, Therese
name: Anderson, Joy
name: Watson, Thomas J.
name: Johnstone, David W.
name: Qazi, Raman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Local and distant failure rates remain high despite aggressive chemoradiation (CRT) treatment for stage III non-small cell lung cancer (NSCLC). We conducted preclinical studies of docetaxel cytotoxic and radiosensitizing effects on lung cancer cell lines and designed a pilot study to target distant micrometastasis upfront with one-cycle induction chemotherapy, followed by low-dose radiosensitizing docetaxel CRT.
Additional file 6 of Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei
Creators: name: Ambros, Conrad L.
name: Ehrmann, Matthias A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6 Fig. S3 Neighbor joining tree of the phage terminase (large subunit) gene of as intact predicted prophages in L. sakei strains. Bootstrap values are based on a Jukes-Cantor model (1000 replicates). The phage terminase (large subunit) genes of phages infecting other lactobacilli were included as outgroups.
On resolving conflicts between arguments
Creators: name: Roos, Nico
Publisher: name: arXiv
Year: 2022
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.4; I.2.3
subject: 68T27, 68T30

description: Argument systems are based on the idea that one can construct arguments for propositions; i.e., structured reasons justifying the belief in a proposition. Using defeasible rules, arguments need not be valid in all circumstances, therefore, it might be possible to construct an argument for a proposition as well as its negation. When arguments support conflicting propositions, one of the arguments must be defeated, which raises the question of \emph{which (sub-)arguments can be subject to defeat}? In legal argumentation, meta-rules determine the valid arguments by considering the last defeasible rule of each argument involved in a conflict. Since it is easier to evaluate arguments using their last rules, \emph{can a conflict be resolved by considering only the last defeasible rules of the arguments involved}? We propose a new argument system where, instead of deriving a defeat relation between arguments, \emph{undercutting-arguments} for the defeat of defeasible rules are constructed. This system allows us, (\textit{i}) to resolve conflicts (a generalization of rebutting arguments) using only the last rules of the arguments for inconsistencies, (\textit{ii}) to determine a set of valid (undefeated) arguments in linear time using an algorithm based on a JTMS, (\textit{iii}) to establish a relation with Default Logic, and (\textit{iv}) to prove closure properties such as \emph{cumulativity}. We also propose an extension of the argument system that enables \emph{reasoning by cases}.
E-RIHS PP D3.4 Financial plan for implementation
Creators: name: Mimoso, João Manuel
name: Pezzati, Luca
Publisher: name: Zenodo
Year: 2020
Subjects: Financial plan
Financial model

description: Financial sustainability is a basic requirement for the success of any endeavour. But behind financial sustainability, there should be a sound financial model backed by a set of general principles ensuring that the management functions do not lead, over time, to unpredicted situations in which the model no longer stands. The basic financial model of the future E-RIHS ERIC was designed prior to the successful application to the ESFRI Roadmap and was screened by its reviewing panel. The present document elaborates on that model towards a proposal of a working financial plan for implementation. E-RIHS ERIC will be a consortium with a formal structure and two operational levels: • the Central Hub represents the ERIC and operates as the access point to the Research Infrastructure; • National Hubs operate at national levels in diverse legal frameworks and represent national associations of partner facilities. Accordingly, the deliverable is organized in three main parts: the first deals with the business description and sources of revenue at the partner level, ending with a review of the financial relations of E-RIHS with its partners; the second proposes a set of encompassing principles ending with a description of the funding model of the Central Hub of E-RIHS; finally, the third part presents the financial plan, starting with a bill of costs and ending with a proposition of the cash contribution of the Members and Observers of the ERIC (EU Member States, EU associated countries, third countries other than associated countries). The Deliverable concludes with a design for the first years of implementation that will ensure financial sustainability in the medium run though a special contribution by the hosting country.
Pulmonary Toxicity in Stage III Non-Small Cell Lung Cancer Patients Treated With High-Dose (74 Gy) 3-Dimensional Conformal Thoracic Radiotherapy and Concurrent Chemotherapy Following Induction Chemotherapy: A Secondary Analysis of Cancer and Leukemia Group B (CALGB) Trial 30105
Creators: name: Crawford, Jeffrey C.
name: Morano, Karen
name: Wang, Xiaofei
name: Salama, Joseph K.
name: Blackstock, A. William
name: Stinchcombe, Thomas E.
name: Bogart, Jeffrey A.
name: Gu, Lin
name: Vokes, Everett E.
name: Socinski, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: CALGB 30105 tested two different concurrent chemoradiotherapy platforms with high dose (74 Gy) 3-D conformal radiotherapy (3DCRT) following two cycles of induction chemotherapy for stage IIIA/IIIB NSCLC patients to determine if either could achieve a primary endpoint of > 18 month median survival. Final results of 30105 demonstrated that induction carboplatin and gemcitabine and concurrent gemcitabine 3DCRT was not feasible due to treatment related toxicity. However, induction and concurrent carboplatin/paclitaxel with 74 Gy 3DCRT had a median survival of 24 months, and is the basis for the experimental arm in CALGB 30610/RTOG 0617/N0628. We conducted a secondary analysis of all patients to determine predictors of treatment related pulmonary toxicity.
Additional file 7 of Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei
Creators: name: Ambros, Conrad L.
name: Ehrmann, Matthias A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7 Fig. S4 Neighbor joining tree of the phage tape measure protein (TMP) gene of as intact predicted prophages in L. sakei strains. Bootstrap values are based on a Jukes-Cantor model (996 replicates). The TMP genes of phages infecting other lactobacilli were included as outgroups.
Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer
Creators: name: Wang, Andrew Z.
name: Moore, Dominic T.
name: Werner, Michael E.
name: Sethi, Manish
name: Cummings, Natalie D.
name: Sukumar, Rohit
name: Wang, Edina C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A key research objective in radiation oncology is to identify agents that can improve chemoradiation therapy. Nanoparticle (NP) chemotherapeutics possess several properties, such as preferential accumulation in tumors, that are uniquely suited for chemoradiation therapy. To facilitate the clinical translation of NP chemotherapeutics in chemoradiation therapy, we conducted preclinical evaluation of Genexol-PM, the only clinically approved NP chemotherapeutic with a controlled drug release profile, as a radiosensitizer using non-small cell lung cancer (NSCLC) as a model disease.
Additional file 8 of Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei
Creators: name: Ambros, Conrad L.
name: Ehrmann, Matthias A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8 Table S1 Examples of genes/putative tasks of annotated proteins within the different phage gene modules and their respective color-coding used in the genome comparison.
title: Übersetzung in Spanisch: Koronare Herzkrankheit. Koronare Herzkrankheit - Was ist das?
Creators: name: Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ)
Publisher: name: Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Ärztliches Zentrum für Qualität in der Medizin (ÄZQ)
Year: 2011
Subjects: subject: 610 Medical sciences; Medicine

description: Kurzinformation für Patienten
Development of the Low Frequency Telescope Focal Plane Detector Modules for LiteBIRD
Creators: name: Westbrook, Benjamin
name: Raum, Christopher
name: Beckman, Shawn
name: Lee, Adrian T.
name: Farias, Nicole
name: Bogdan, Andrew
name: Hornsby, Amber
name: Suzuki, Aritoki
name: Rotermund, Kaja
name: Elleflot, Tucker
name: Austermann, Jason E.
name: Beall, James A.
name: Duff, Shannon M.
name: Hubmayr, Johannes
name: Vissers, Michael R.
name: Link, Michael J.
name: Jaehnig, Greg
name: Halverson, Nils
name: Ghigna, Tomasso
name: Hazumi, Masashi
name: Stever, Samantha
name: Minami, Yuto
name: Thompson, Keith L.
name: Russell, Megan
name: Arnold, Kam
name: Silva-Feaver, Maximiliano
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: LiteBIRD is a JAXA-led strategic large-class satellite mission designed to measure the polarization of the cosmic microwave background and Galactic foregrounds from 34 to 448 GHz across the entire sky from L2 in the late 2020s. The scientific payload includes three telescopes which are called the low-, mid-, and high-frequency telescopes each with their own receiver that covers a portion of the mission's frequency range. The low frequency telescope will map synchrotron radiation from the Galactic foreground and the cosmic microwave background. We discuss the design, fabrication, and characterization of the low-frequency focal plane modules for low-frequency telescope, which has a total bandwidth ranging from 34 to 161 GHz. There will be a total of 4 different pixel types with 8 overlapping bands to cover the full frequency range. These modules are housed in a single low-frequency focal plane unit which provides thermal isolation, mechanical support, and radiative baffling for the detectors. The module design implements multi-chroic lenslet-coupled sinuous antenna arrays coupled to transition edge sensor bolometers read out with frequency-domain mulitplexing. While this technology has strong heritage in ground-based cosmic microwave background experiments, the broad frequency coverage, low optical loading conditions, and the high cosmic ray background of the space environment require further development of this technology to be suitable for LiteBIRD. In these proceedings, we discuss the optical and bolometeric characterization of a triplexing prototype pixel with bands centered on 78, 100, and 140 GHz.
description: SPIE Astronomical Telescope + Instrumentation (AS22)