cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HYGIENIC PRACTICES DURING MILKING AND BACTERIOLOGICAL QUALITY OF THE MILK IN RAW BOVINE BULK MILK IN THE SELECTED MILK COLLECTION CENTERS: SMALLHOLDER DAIRY PROCESSING ETHIOPIA.
Creators: name: WODAJO, HIWOT DESTA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: General Abstract A cross-sectional study was conducted with a total of 201 member farmers in Arsi Zone and East Shewa Zone, in Oromia, Ethiopia. The purpose of the study was to a assess hygienic practices during milking, milk collection and bacteriological quality of the milk of raw bovine bulk milk in Arsi and East Shewa Zones milk collection centers; the study targeted smallholder dairy processing activities. In Arsi Zones majority of the household heads were male while in East Shewa Zone female were the majority. Main feed used by the respondents was mineral block, oilseed cake, and barn, followed by hay, crop residue, bran, local brewer?s yeast and stover\straw and some feed were roughage and/or concentrates. Indoor feeding was common while some used only grazing system. Regarding watering, majority of the respondents, in most cases, used tap water but used river water on rare cases. The average age at first calving in Digeluna Tiyo district is 38.33 months relatively longer than 25.95 months in Tiyo district. The longest calving interval 17.17 months was recorded in Lemuna Bilbilo district, while the shortest was in Tiyo district 14.10 months. The average milk production for local dairy cattle in Tiyo district is 1.45 liters/day, which is less compared to 2.55 liters/day in Lemuna Bilbilo district. The average milk production for crossbred dairy cattle ranged from 5.07 liters/day in Digeluna Tiyo district whereas it was 11.73 liters/day in Tiyo district. Predominantly women do milking. Most of the respondents practiced milking their local and crossed cows twice per day (early in the morning and late in the afternoon) respectively. All the respondents stated that they wash their hands but most respondents wash udder of the cow also before milking. Some of the respondents indicated that they use towel for cleaning the teats before milking the cows. Large proportion of respondents uses plastic as milk container followed by metal and traditional pots. A total of 106 samples of milk were collected to assess bacteriological quality of bulk raw milk. Total of 246 bacterial isolates were obtained from milk samples taken. These included Escherichia coli 19.8%, Listeria monocytogenes 1.2%, Staphylococcus aureus 3.2%and Brucella3.3%. Based on the bacterial isolates found a total of 100 samples of milk were collected to analyzeMethicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli O157 serotype. Among the total milk samples analyzed for each pathogen, 50.5% were Staphylococcus of which Staphylococcus aureus were (5.05%), and (47.5%) Escherichia coli were also analyzed from the (49.5%) Enterobacteriaceae isolated. Out of the Staphylococcus aureus recovered, all the isolates were sensitive to Methicillin Resistant Staphylococcus aureus (MRSA) test and 27.8% of the recovered Escherichia coli were positive for E coli O157 serotype.
PENA MINACCIATA E ATTI ESECUTIVI: UNO STUDIO IN MATERIA DI TENTATIVO
Creators: name: ABBADESSA, GIORGIO
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: The idea of deterrence requires that a person can be considered guilty of attempting only if he starts to commit the offence. Preparatory acts are not attempt acts.
QCD Jet Rates with the Inclusive Generalized kt Algorithms
Creators: name: Gerwick, Erik
name: Gripaios, Ben
name: Schumann, Steffen
name: Webber, Bryan
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We derive generating functions, valid to next-to-double logarithmic accuracy, for QCD jet rates according to the inclusive forms of the kt, Cambridge/Aachen and anti-kt algorithms, which are equivalent at this level of accuracy. We compare the analytical results with jet rates and average jet multiplicities from the SHERPA event generator, and study the transition between Poisson-like and staircase-like behaviour of jet ratios.
description: 31 pages, 8 figures (Corrected typos in eqs.5.1,5.2,5.9 and clarified notation in 5.4)
Additional file 2 of Unraveling the phenotypic and genomic background of behavioral plasticity and temperament in North American Angus cattle
Creators: name: Alvarenga, Amanda B.
name: Oliveira, Hinayah R.
name: Turner, Simon P.
name: Garcia, Andre
name: Retallick, Kelli J.
name: Miller, Stephen P.
name: Brito, Luiz F.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S1. Manhattan plot for each age group of cows at weaning temperament (CT) considering the absolute effect of SNP-window.
TUMOR SUPPRESSIVE ROLE OF THE POLYCOMB GROUP RING FINGER PROTEIN PCGF6 IN MYC-INDUCED LYMPHOMAGENESIS
Creators: name: TANASKOVIC, NINA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: The Myc oncoprotein is a bHLH-LZ transcription factor that heterodimerizes with another bHLH-LZ protein, Max, in order to bind DNA and activate transcription. Max also dimerizes with alternative bHLH-LZ partners, including Mxd1-4, Mnt and Mga: these proteins act as transcriptional repressors, are thought to counteract Myc activity at common target genes, and may thus conceivably act as tumor suppressors. Consistent with this concept, Small Cell Lung Cancer (SCLC) shows sporadic loss of either Max or Mga, as well as Myc amplification: all of these events are mutually exclusive, pointing to a common functional consequence. At the molecular level, Max and Mga are also part of a variant of the Polycomb Repressive Complex (PRC1.6), the function of which ? if any ? in tumorigenesis remains to be characterized. Based on the above observations, we hypothesized that Mga/Max dimers may recruit the PRC1.6 complex to chromatin, thereby antagonizing Myc/Max function. We further speculated that this may endow Mga and/or Pcgf6 with widespread tumor suppressor activity, possibly extending to tumor types other than SCLC. Here, we addressed the roles of Pcgf6 and Mga in E?-myc transgenic mice, a well- characterized model of Myc-induced lymphomagenesis. Remarkably, B-cell specific deletion of Pcgf6 ? but not Mga ? led to a marked acceleration in lymphoma onset. As assessed by ChIP- and RNA-seq profiling, loss of Mga or Pcgf6 affected neither DNA-binding by Myc/Max, nor Myc-regulated transcription. Nonetheless, while having no impact tumor onset, deletion of Mga led to a near-complete loss of Pcgf6 recruitment to chromatin, implying that Pcgf6 suppressed lymphomagenesis through an alternative mechanism. Close inspection of mRNA profiles indicated that Pcgf6-null lymphomas were associated with a mild downregulation of genes involved in immune surveillance pathways. Immunophenotypic 9 profiling of infiltrating cells in transplanted lymphomas pointed to a reduction in infiltrating T-cells, and in particular of effector CD8+ and CD4+ T-cells in Pcgf6-null tumors. Altogether, we have shown that Pcgf6 acts as a tumor suppressor in a model of Myc-induced B-cell lymphoma, but does so in a Mga- and PRC1.6-independent manner. While cell- autonomous Pcgf6-dependent effects in lymphoma B-cells remain to be addressed, our data point to a possible non-cell autonomous function of Pcgf6 in T-cell recruitment and/or activation, and thus possibly in tumor rejection.
Possible latitude effects of Chern-Simons gravity on quantum interference
Creators: name: Okawara, Hiroki
name: Yamada, Kei
name: Asada, Hideki
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It has been recently suggested that possible effects of Chern-Simons gravity on a quantum interferometer are dependent on the latitude and direction of the interferometer on Earth in orbital motion around Sun. Continuing work initiated in the earlier publication [Okawara, Yamada and Asada, Phys. Rev. Lett. 109, 231101 (2012)], we perform numerical calculations of time variation in the induced phase shifts for nonequatorial cases. We show that the maximum phase shift at any latitude might occur at 6, 0 (and 12), and 18 hours (in local time) of each day, when the normal vector to the interferometer is vertical, eastbound and northbound, respectively. If two identical interferometers were located at different latitudes, the difference between two phase shifts that are measured at the same local time would be $O(\sin δφ)$ for a small latitude difference $δφ$. It might thus become maximally $\sim 20$ percents for $δφ\sim 10$ degrees, for instance.
description: 18 pages, 5 figures, text improved with references added; accepted by PRD. arXiv admin note: substantial text overlap with arXiv:1210.4628
Tracking Down the Source Population Responsible for the Unresolved Cosmic 6-8 keV Background
Creators: name: Xue, Y. Q.
name: Wang, S. X.
name: Brandt, W. N.
name: Luo, B.
name: Alexander, D. M.
name: Bauer, F. E.
name: Comastri, A.
name: Fabian, A. C.
name: Gilli, R.
name: Lehmer, B. D.
name: Schneider, D. P.
name: Vignali, C.
name: Young, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using the 4 Ms Chandra Deep Field-South (CDF-S) survey, we have identified a sample of 6845 X-ray undetected galaxies that dominates the unresolved ~ 20-25% of the 6-8 keV cosmic X-ray background (XRB). This sample was constructed by applying mass and color cuts to sources from a parent catalog based on GOODS-South HST z-band imaging of the central 6'-radius area of the 4 Ms CDF-S. The stacked 6-8 keV detection is significant at the 3.9 sigma level, but the stacked emission was not detected in the 4-6 keV band which indicates the existence of an underlying population of highly obscured active galactic nuclei (AGNs). Further examinations of these 6845 galaxies indicate that the galaxies on the top of the blue cloud and with redshifts of 1 < z < 3, magnitudes of 25 < z_850 < 28, and stellar masses of 2E8 < M_star/M_sun < 2E9 make the majority contributions to the unresolved 6-8 keV XRB. Such a population is seemingly surprising given that the majority of the X-ray detected AGNs reside in massive (> ~1E10 M_sun) galaxies. We discuss constraints upon this underlying AGN population, supporting evidence for relatively low-mass galaxies hosting highly obscured AGNs, and prospects for further boosting the stacked signal.
description: 15 pages, 9 figures, 4 tables, accepted to be published in ApJ
Gauss-Bonnet dark energy by Lagrange multipliers
Creators: name: Capozziello, Salvatore
name: Makarenko, Andrey N.
name: Odintsov, Sergei D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A string-inspired effective theory of gravity, containing Gauss-Bonnet invariant interacting with a scalar field, is considered in view of obtaining cosmological dark energy solutions. A Lagrange multiplier is inserted into the action in order to achieve the cosmological reconstruction by selecting suitable forms of couplings and potentials. Several cosmological exact solutions (including dark energy of quintessence, phantom or Little Rip type) are derived in presence and in absence of the Lagrange multiplier showing the difference in the two dynamical approaches. In the models that we consider, the Lagrange multiplier behaves as a sort of dust fluid that realizes the transitions between matter dominated and dark energy epochs. The relation between Lagrange multipliers and Noether symmetries is discussed.
description: 14 pages, expanded version to appear in PRD
Aus staufischer Zeit
Creators: name: Waldburg-Wolfegg, Hubert
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 16, Nr. 1 (1975): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Starlight Demonstration of the Dragonfly Instrument: an Integrated Photonic Pupil Remapping Interferometer for High Contrast Imaging
Creators: name: Jovanovic, N.
name: Tuthill, P. G.
name: Norris, B.
name: Gross, S.
name: Stewart, P.
name: Charles, N.
name: Lacour, S.
name: Ams, M.
name: Lawrence, J. S.
name: Lehmann, A.
name: Niel, C.
name: Robertson, J. G.
name: Marshall, G. D.
name: Ireland, M.
name: Fuerbach, A.
name: Withford, M. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In the two decades since the first extra-solar planet was discovered, the detection and characterization of extra-solar planets has become one of the key endeavors in all of modern science. Recently direct detection techniques such as interferometry or coronography have received growing attention because they reveal the population of exoplanets inaccessible to Doppler or transit techniques, and moreover they allow the faint signal from the planet itself to be investigated. Next-generation stellar interferometers are increasingly incorporating photonic technologies due to the increase in fidelity of the data generated. Here, we report the design, construction and commissioning of a new high contrast imager; the integrated pupil-remapping interferometer; an instrument we expect will find application in the detection of young faint companions in the nearest star-forming regions. The laboratory characterisation of the instrument demonstrated high visibility fringes on all interferometer baselines in addition to stable closure phase signals. We also report the first successful on-sky experiments with the prototype instrument at the 3.9-m Anglo-Australian Telescope. Performance metrics recovered were consistent with ideal device behaviour after accounting for expected levels of decoherence and signal loss from the uncompensated seeing. The prospect of complete Fourier-coverage coupled with the current performance metrics means that this photonically-enhanced instrument is well positioned to contribute to the science of high contrast companions.
description: 10 pages, 7 figures, accepted to Mon. Not. of Roy. Ast. Soc., 2012
CARATTERIZZAZIONE DELL�ORGANELLO DI NEUROMELANINA DELLA SUBSTANTIA NIGRA UMANA CON APPROCCIO PROTEOMICO
Creators: name: VANNA, RENZO
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Substantia nigra is the most affected brain region in Parkinson's disease. Substantia nigra is characterized by strong pigmentation derived by the presence of neuromelanin (NM), a particular melanic pigment that accumulates during aging in neurons in typical membrane-bounded organelles with high levels of lipids (dolichols). The occurrence of an elevated number of NM organelles in the most vulnerable brain region during Parkinson?s disease is of special interest. It is not clear if NM organelles may interfere with the vulnerability of neurons during aging. Nevertheless, many evidences support the correlation between aging and neurodegeneration, and the accumulation of intracellular indigestible materials (damaged proteins, inclusion bodies and lipofuscins). The accumulation of indigestible materials inside the cell may increase cellular stress and neurodegeneration. In this study, samples of NM organelles (whole and without membranes) and NM pigment were isolated from human post-mortem tissue (substantia nigra) of healthy subjects. Samples were analysed in duplicate to obtaining the proteomic profile of the NM organelle using MudPIT proteomic technology. A total of 1142 proteins were identified, of which 48 were observed with high confidence as representative of samples. Comparing results from different samples, some proteins were assigned to different regions of the NM organelle (NM pigment, membrane, soluble portion). From the proteomic profile emerges the lysosomal nature of the NM organelle: among the 48 representative proteins, more than 20 are lysosomal proteins. In addition, other groups of proteins were identified: proteins involved in protein folding (alpha-crystallin) and degradation (ubiquitin), proteins important to iron homeostasis (ferritin L), antioxidant proteins and proteins involved in intracellular aggregates formation. Furthermore, typical biomarkers of lysosomal storage disease are observed (mitochondrial subunit c, saposins). On the other hand, any enzyme potentially involved in the melanogenic process and any lipids biosynthetic enzyme were identified. This study demonstrates that the NM organelle has the features of both a lysosomal/autophagic organelle and an aged and damaged lysosome accumulating indigestible material. These data are in agreement with recent hypothesis suggesting that the NM organelle formation originate by sequestration of NM and other potentially toxic molecules as damaged proteins, damaged lipids and metals. Our data suggest that this protective mechanism, during aging, may induce accumulation of indigestible material inside the NM organelles and, as consequence, a decreased degradative function of the cell. In summary, e suggest that NM organelle could confer protection to neurons and, at the same time, could increase cellular vulnerability in aging conditions.
Fünftes Burgenseminar auf Schloß Dhaun
Creators: name: Römer, Johannes F.
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 16, Nr. 1 (1975): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Supplementary material: Knowing the fishery to know the bycatch from Knowing the fishery to know the bycatch: bias-corrected estimates of harbour porpoise bycatch in gillnet fisheries
Creators: name: Kindt-Larsen, Lotte
name: Glemarec, Gildas
name: Berg, Casper W.
name: Königson, Sara
name: Kroner, Anne-Mette
name: Søgaard, Mathias
name: Lusseau, David
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Incidental captures (bycatch) remain a key global conservation threat for cetaceans. Bycatch of harbour porpoise Phocoena phocoena in set gillnets is routinely monitored in European Union fisheries, but generally relies on data collected at low spatio-temporal resolution or over short periods. In Denmark, a long-term monitoring programme started in 2010 using electronic monitoring to collect data on porpoise bycatch and gillnet fishing effort at a fine spatial and temporal scale, including time and position of each fishing operation, together with every associated bycatch event. We used these observations to model bycatch rates, given the operational and ecological characteristics of each haul observed in Danish waters. Fishing effort from the Danish and Swedish gillnet fleets was collected to predict fleet-wide porpoise bycatch in gillnets at regional level. Between 2010 and 2020, yearly total bycatch averaged 2088 animals (95% Cl: 667–6798). For the Western Baltic assessment unit, bycatch levels were above sustainability thresholds. These results demonstrate that fishing characteristics are key determinants of porpoise bycatch and that classical approaches ignoring these features would produce biased estimates. It emphasizes the need for efficient and informative monitoring methods to understand possible conservation impacts of marine mammal bycatch and implement tailored mitigation techniques.
Additional file 1 of Enhancement of dynamic visual acuity using transcranial alternating current stimulation with gamma burst entrained on alpha wave troughs
Creators: name: Park, Jimin
name: Lee, Sangjun
name: Choi, Dasom
name: Im, Chang-Hwan
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health
subject: Cardiology

description: Additional file 1: Additional analyses of data.
Burgenfahrt der Deutschen Burgenvereinigung in die Normandie 16.-21. Juni 1975
Creators: name: Meyer, Werner
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 16, Nr. 2 (1975): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
LA GARANZIA IMPROPRIA: PROFILI DI DIRITTO PROCESSUALE
Creators: name: MOSCHELLA, CONSUELO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: ABSTRACT Consuelo Moschella Phd dissertation (Matr. R10699-R31) The improper warranty: procedural law aspects. The dissertation deals with the theme of the so called improper warranty. Traditionally distinguished and opposed to the proper warranty, the improper warranty has always been considered a minus compared to the first one. The differentiation between the two figures, mainly based on the supposed autonomy of the questions in the hypothesis of call on an improper warranty, has seen for a long time the disapplication for all the cases included in this category of the procedural law provisions, usually applied in case of call on an improper warranty, ie articles 32, 108, 331 c.p.c. With the innovative sentence of the United Sections of the Court of Cassation, n. 24707 of December the 4th, 2015, this historical differentiation of the procedural regime between the two categories of guarantee, unknown to the other jurisdictions, has definitely vanished, remaining only as a distinction with merely descriptive character. Despite the fact that the intervention by the Court of Cassation has definitively declared as outdated the previous applicative distinction, some doubts about the appropriateness and juridical correctness of the definitive abandonment of the said distinction still remains for part of the doctrine. This study it intended to deal with the figure of improper warranty from its origins to its current regulation, without failing to examine the aspects still controversial today.
Additional file 1 of Excess mortality and the COVID-19 pandemic: causes of death and social inequalities
Creators: name: Oh, Jieun
name: Min, Jieun
name: Kang, Cinoo
name: Kim, Ejin
name: Lee, Jung Pyo
name: Kim, Ho
name: Lee, Whanhee
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Table S1. Causes of death and corresponding ICD-10 codes. Supplementary Table S2. Characteristics of the 16 regions in Korea. Supplementary Methods. Supplementary Table S3. Number of total deaths and estimated excess deaths (with 95% empirical confidence intervals) during the COVID-19 pandemic period (February 18 to December 31, 2020) in Korea by cause of death and phase of the pandemic. Supplementary Table S4. Percentage excess in mortality (with 95% empirical confidence interval) during the COVID-19 pandemic period (February 18 to December 31, 2020) in Korea by cause of death and individual characteristic. Supplementary Table S5. Percentage excess in mortality (with 95% empirical confidence interval) by cause of death for main model and each sensitivity analysis. Supplementary Table S6. Percentage excess in mortality (with 95% empirical confidence interval) by individual characteristic for main model and each sensitivity analysis. Supplementary Table S7. Number of total deaths (%) during the COVID-19 pandemic period (February 18 to December 31, 2020) in Korea by cause of death and individual characteristic. Supplementary Table S8. Number of total deaths (%) by main specific causes of Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99) in 2020. Supplementary Figure S1. Temporal trends of total deaths during the study period (2015–2020).
FURTHER INSIGHT INTO V-ATPASE ROLE IN GLIOMA STEM CELLS
Creators: name: STORACI, ALESSANDRA MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: V-ATPase is a proton pump mainly localized on lysosomes and on plasma membrane of specialized cells. It is responsible of proton translocation and acidification of intra- and extra-cellular environment. Our group demonstrated that the over-expression of the subunit G1 (V1G1) is involved in the maintenance of the stem cell niche in glioblastoma (GBM) and correlates with poor prognosis in GBM patients. In this work we aimed to elucidate the role of V-ATPase in GBM stem cells from a functional perspective. We demonstrated that neurospheres (NS) with higher levels of V1G1 subunit (High-V1G1), compared with NS with lower levels of V1G1 (Low-V1G1), were characterized by increased clonogenicity in vitro and in vivo, invasiveness, lysosomal acidification and ERK pathway activation. Specific inhibition of V-ATPase activity, by Bafilomycin (BafA1), but not of ERK or other lysosomal drugs, induced reactive oxygen species (ROS)-mediated apoptosis only in High-V1G1 NS. In addition, BafA1 treatment affected mitochondria homeostasis only in High-V1G1 NS. Preliminary experiments suggested that a V-ATPase pump might be localized on the mitochondria or it could mediate direct contacts between mitochondria and lysosomes thus causing an imbalance of charges (proton flux) when perturbed. Finally, High-V1G1 and Low-V1G1 NS differed in terms of metabolic behaviours: preferential use of glycolysis by Low-V1G1 NS opposite to use of oxidative metabolism in High-V1G1 NS. V-ATPase block by BafA1 in High-V1G1 NS shifted their metabolism to that of Low-V1G1 NS. On the other hand, the autophagic pathway, that is directly connected with lysosomal function, was blocked by BafA1 only in Low-V1G1 NS. These phenotypes were not modulated by ERK or lysosomal acidification inhibitors alone, indicating a specific role for V-ATPase proton pump in modulating them. Taken together, these results indicate that V-ATPase is crucial for GBM stem cells viability through different mechanisms that include bioenergetics sensing and requiring, mitochondrial homeostasis and ERK signalling activity.
Supplementary material from "Dollo meets Bergmann: Morphological evolution in secondary aquatic mammals"
Creators: name: Farina, B. M.
name: Faurby, S.
name: Silvestro, D.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Computational Biology

description: Supplementary figures and tables.
An in situ displacement method to evaluate demulsification performance of demulsifiers
Creators: name: Yang, Ziyi
name: Duan, Ming
name: Li, Yang
name: Chen, Qiming
name: Fang, Shenwen
name: Liu, Xianming
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Chemical demulsification is the most effective, common and the cheapest method to break crude oil emulsion during oil extraction. The chemical demulsification process is related with the natural emulsifier displacement by demulsifier. In this article, a single droplet in situ displacement method was employed to evaluate demulsifier displace capacity and the experimental device was built. This device determines the displacement capacity of demulsifier by measuring the oil-water interfacial tension, demulsifier concentration and saturated adsorption amount of demulsifier. Displacement capacities of four commercially available polyether demulsifiers and the relationship between demulsifier displacement capacity and demulsification performance were investigated. The results showed that the demulsifier displacement capacity was not affected by natural emulsifier type (asphaltene, resin, or mixture of asphaltene) and was related to the demulsifier type, concentration, and temperature. Demulsifier displacement capacity increased with demulsifier concentration and temperature. However, only when the asphaltene concentration of was over 6.78 wt%, the demulsification increased with demulsifier displacement capacity.
Charged kaon femtoscopic correlations in pp collisions at $\sqrt{s}=7$ TeV
Creators: name: ALICE Collaboration
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Correlations of two charged identical kaons (${\rm K}^{\rm ch}{\rm K}^{\rm ch}$) are measured in pp collisions at $\sqrt{s}=7$~TeV by the ALICE experiment at the Large Hadron Collider (LHC). One-dimensional ${\rm K}^{\rm ch}{\rm K}^{\rm ch}$ correlation functions are constructed in three multiplicity and four transverse momentum ranges. The ${\rm K}^{\rm ch}{\rm K}^{\rm ch}$ femtoscopic source parameters $R$ and $λ$ are extracted. The ${\rm K}^{\rm ch}{\rm K}^{\rm ch}$ correlations show a slight increase of femtoscopic radii with increasing multiplicity and a slight decrease of radii with increasing transverse momentum. These trends are similar to the ones observed for $ππ$ and ${\rm K}^0_{\rm s}{\rm K}^0_{\rm s}$ correlations in pp and heavy-ion collisions. However at high multiplicities, there is an indication that the one-dimensional correlation radii for charged kaons are larger than those for pions in contrast to what was observed in heavy-ion collisions at RHIC.
description: 17 pages, 4 captioned figures, 1 table, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/2840
Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: Growth arrest without a change in α/β ratio
Creators: name: Yu, Jing
name: Lu, Ryan
name: Nedrow, Jessie R.
name: Sgouros, George
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Agents that increase tumor radiosensitivity are of interest in improving outcomes in radiotherapy (XRT). DNA-PK inhibitors lead to radiosensitization and also to alterations in cell adhesion proteins. We investigated the combination of radiation and a DNA-PK inhibitor in monolayer vs spheroid culture cells. Materials and Methods: Using a HER2 positive mammary carcinoma cell line, NT2.5, we investigated the impact of NU7441, a potent and selective DNA-PK inhibitor together with external beam irradiation in both 2D monolayer and 3D spheroid cell culture systems. Colony formation assays were performed for cell from monolayer culture cells and spheroids after different dose of external beam irradiation or incubated with NU7441 (5 µM) for 24 h after irradiation. Results: In monolayer culture cells, α/β increased from 3.0 ± 0.2 Gy (XRT alone) to 6.9 ± 0.2 Gy (XRT + NU7441). Corresponding α/β values for cells obtained by disaggregating treated spheroids were 3.6 ± 0.7 Gy (XRT alone) and 3.5 ± 0.2 Gy (XRT + NU7441). In contrast to the minimal change in α/β, spheroids survival was highly sensitive to NU7441 incubation. 21 days after 0, 2, 4, 6, 8, or 10 Gy XRT alone 100, 83, 75, 63, 56, and 31%, respectively, of the irradiated spheroids remained intact; when NU7441 treatment was involved, 56% remained intact at 2 Gy and 13% at 4 Gy, no spheroids survived to 3 weeks at 6 Gy or more. We also found a progressive increase in fragmentation for spheroids exposed only to NU7441. The discrepancy between the minimal change in α/β from cells derived from spheroids and the spheroid growth response was not related to poor penetration of NU7441 since the colony formation assay results for different sizes of spheroids (180 to 400 µm) treated with 4 Gy with or without NU7441were not significantly different. Conclusions: DNA-PK inhibitor NU7441 radiosensitized 2D cultured NT2.5 monolayer cells but not cells obtained from 3D cultured spheroids. The combination, NU7441 and radiation led to an increase in spheroid fragmentation compared to spheroids treated only with radiation.
Extension of a Low-order Model for Detonation Velocity Suppression in Rotation Detonation Combustors
Creators: name: P. Barnouin
name: E. Bach
name: Paschereit, Christian O.
name: Gutmark, Ephraim J.
name: M. D. Bohon
Publisher: name: Zenodo
Year: 2023
Subjects: Rotating Detonation Combustors (RDC)
Low order Model
Detonation

description: In experimental rotating detonation combustor (RDC) studies, the detonation wave propagates at 70 − 80% of the Chapman Jouguet (CJ) speed.
 Multiple mechanisms could contribute to the reduction in measured detonation wave speeds, such as non ideal injection and mixing, exhaust gas dilution, deflagrative burning, heat loss, viscous processes and lateral relief. But quantifying the effect of these processes using traditional RDC combustor diagnostics is difficult. A low order model was developed to provide rough estimates of injection and combustion parameters that are not easily measurable in the RDC. Three mechanisms were incorporated: the buffer region created by non premixed reactant injection, parasitic combustion of reactants, and suppression of the heat release through the detonation.
 The low order model is here extended by integrating different types of experimental inputs to improve first order estimates of the low order model by integrating more realistic boundary conditions.
title: Enacting the Glastonbury Pilgrimage through Communitas and Aural/Visual Culture
Creators: name: Barush, Kathryn. R.
Publisher: name: Technological University Dublin
Year: 2018

description: The sacred sites of Glastonbury in Somerset, England have long been places of pilgrimage, connected to the legend of the journey of Joseph of Arimathea to the British Isles, and have fired the imagination from the Middle Ages to today - inspiring the Arthurian legends, folk-stories and song, and visual representations. In response to the question ‘What is Pilgrimage,’ this essay seeks to explore the conjunction of artistic representations and geographic journeys to and among the ancient topography and mysterious structures of Glastonbury, with a particular focus on how sacred travel, and especially an experience of communitas, can be engendered through art and material culture. This Turnerian notion is understood here as expanding beyond the sense of community enacted within a group of pilgrims and used to describe the complex reception of a symbol vehicle - such as a visual representation or song - as a site of community where, through the act of viewing, the beholder connects to those who have seen the object, person, or image before and those who will see the image in the future. As in all sacred art, the forms and iconography take on an ontological capacity, leading the viewer beyond the person or landscape represented to the thing itself, and hence function as powerful aids to prayer and meditative experience. The work of several thematically connected artists who live (or lived) and work in England - William Blake, Aidan Hart, and the founders of the British Pilgrimage Trust - will serve as case studies; all draw on the legends and sacred stories surrounding the imbued and highly-charged Glastonbury landscape, inviting the viewer to embark on a contemplative pilgrimage through pictures (and, in Blake’s case, lyrical poetry). A look at the efforts of the BPT to engage in an intentional temporal shift through the use of musical entrainment and Blake’s lyrics will underscore the continued importance of the Glastonbury legends in cultural expression.
Thin films thickness Measurement by the conductivity theory in the framework of born approximation
Creators: name: Jannesar, M.
name: Jafari, G. R.
name: Farahani, S. Vasheghani
name: Moradi, S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: When the thickness of the layer is smaller than the electrons mean free path, the morphology affects the conductivity directly based on the layer thickness. This issue provides basis in order to estimate the thickness of the layer by understanding the morphology and the value of the conductivity. This method is an inverse approach on thickness estimation and is applied to various samples. The comparison of the results with other thickness estimations shows good consistency. The benefits of this approach is that the only parameter that needs to be measured is the conductivity, which is quite trivial. Despite the simplicity of this approach, its results would prove adequate to study both the material properties and the morphology of the layer. In addition, the possibility of repeating the measurements on thickness for AC currents with various frequencies enables averaging the measurements in order to obtain the most precise results.
description: 11 pages, 4 figures
Guidelines for Publications of the Romano-Germanic Commission (RGK)
Creators: name: Redaktion, Die
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 94 (2016)
Additional file 1 of MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis
Creators: name: Khan, Parvez
name: Siddiqui, Jawed Akhtar
name: Kshirsagar, Prakash G.
name: Venkata, Ramakanth Chirravuri
name: Maurya, Shailendra Kumar
name: Mirzapoiazova, Tamara
name: Perumal, Naveenkumar
name: Chaudhary, Sanjib
name: Kanchan, Ranjana Kumari
name: Fatima, Mahek
name: Khan, Md Arafat
name: Rehman, Asad Ur
name: Lakshmanan, Imayavaramban
name: Mahapatra, Sidharth
name: Talmon, Geoffrey A.
name: Kulkarni, Prakash
name: Ganti, Apar K.
name: Jain, Maneesh
name: Salgia, Ravi
name: Batra, Surinder Kumar
name: Nasser, Mohd Wasim
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1.
TRAPIANTO DI POLMONE E PRIMARY GRAFT DYSFUNCTION: ANALISI DEI FATTORI DI RISCHIO ED OUTCOME
Creators: name: MENDOGNI, PAOLO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: La Primary Graft Dysfunction (PGD) � una grave forma di danno acuto polmonare dopo trapianto di polmone. Sono stati pubblicati diversi studi che hanno identificato vari fattori di rischio per PGD grave (grado 3), relativi a donatore, ricevente e variabili operatorie. Lo scopo dello studio � stato analizzare i fattori di rischio per PGD presso un centro a basso volume di interventi e confrontarli ai dati descritti in letteratura. Lo studio ha analizzato in modo retrospettivo 45 procedure di trapianto di polmone eseguite da Gennaio 2011 a Settembre 2013. L?incidenza di PGD di grado 3 � stata del 35,5%, 17,7% e 15,5% rispettivamente a 24, 48, 72 ore dal trapianto. Sono stati identificati i seguenti fattori di rischio a T24: sesso femminile del ricevente, utilizzo di ECMO come bridge al trapianto di polmone causa di morte del donatore diverse da ictus cerebri o trauma, trasfusioni di sangue durante l?intervento chirurgico, l?utilizzo di ECMO veno-arterioso intraoperatorio. A T48 l?unico fattore di rischio identificato � stato l?utilizzo di ECMO come bridge al trapianto. A T72 i fattori di rischio identificati sono stati: diagnosi miste e causa di morte del donatore diverse da ictus cerebri e trauma. I fattori di rischio per PGD di grado 3 presso il nostro centro trapianti sono assimilabili ai dati riportati in letteratura.
Additional file 1 of Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
Creators: name: Wu, Yu-Ting
name: Tay, Hui-Yi
name: Yang, Jung-Tse
name: Liao, Hsiao-Hui
name: Ma, Yi-Shing
name: Wei, Yau-Huei
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Mental Health

description: Additional file 1: Table S1. The relationship between the heteroplasmy level of m.8344A > G mutation and its effects on the biological functions of neural cells derived from MERRF-iPSCs.
Sie sind eingeladen zu einer bildschönen Entdeckungsreise in die Welt der Ritter und Burgen! / DM 5.000,- / Behalten Sie Ihr Holz im Auge
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 17, Nr. 2 (1976): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Σχεδιασμός, κατασκευή και προγραμματισμός ρομποτικού βραχίονα
Creators: name: Δεληκωνσταντινου Βασιλειος
Publisher: name: Technical University of Crete
Year: 2016

description: Στην παρούσα διπλωματική εργασία παρουσιάζεται ο σχεδιασμός, η κατασκευή και ο προγραμματισμός ενός ρομποτικού συστήματος, το οποίο έχει ως κύρια εργασία τη γραφή λέξεων που εισάγονται από τον χρήστη. Το ρομποτικό, αυτό, σύστημα αποτελείται από δύο υποσυστήματα, τα οποία επικοινωνούν μεταξύ τους. Το ένα υποσύστημα είναι ένας επίπεδος βραχίονας δύο περιστροφικών αρθρώσεων, ο οποίος γράφει τις λέξεις που εισάγονται, ενώ το άλλο υποσύστημα αποτελείται από έναν άξονα, με ενσωματωμένο σφουγγάρι, ο οποίος είναι συνδεδεμένος με έναν σερβοκινητήρα, έτσι ώστε να περιστρέφεται στο επίπεδο του πίνακα γραφής και να σαρώνει την επιφάνειά του, καθαρίζοντάς τον. Ο έλεγχος και ο προγραμματισμός του συστήματος γίνεται από την πλατφόρμα Arduino και η γλώσσα προγραμματισμού του είναι η Wiring C. Ο στόχος της παρούσας εργασίας, είναι η κατασκευή του προαναφερθέντος ρομποτικού συστήματος με τα εξής κριτήρια: την πρωτοτυπία του σχεδίου, την απλότητα στην κατασκευή και τη λειτουργία του, τη χρήση, κυρίως, εργαλείων χειρός, την επαναχρησιμοποίηση αντικειμένων και εξαρτημάτων, τα οποία βρίσκονται στα περισσότερα σπίτια, καθώς και το χαμηλό κόστος κατασκευής. Ο σκοπός της παρούσας εργασίας είναι εκπαιδευτικός και αφορά στην κατανόηση της λειτουργίας των ρομποτικών συστημάτων.
Die Wikingerfestung von Fyrkat (Dänemark)
Creators: name: Roesdahl, Else
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 15, Nr. 1 (1974): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Additional file 1 of High-intensity walking in midlife is associated with improved memory in physically capable older adults
Creators: name: Choe, Young Min
name: Suh, Guk-Hee
name: Lee, Boung Chul
name: Choi, Ihn-Geun
name: Kim, Hyun Soo
name: Kim, Jong Wan
name: Hwang, Jaeuk
name: Yi, Dahyun
name: Kim, Jee Wook
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1.
Robust Surface Doping of Bi$_2$Se$_3$ by Rb Intercalation
Creators: name: Bianchi, Marco
name: Hatch, Richard C.
name: Li, Zheshen
name: Hofmann, Philip
name: Song, Fei
name: Mi, Jianli
name: Iversen, Bo Brummerstedt
name: El-Fattah, Zakaria M. Abd
name: Löptien, Peter
name: Zhou, Lihui
name: Khajetoorians, Alexander Ako
name: Wiebe, Jens
name: Wiesendanger, Roland
name: Wells, Justin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Rubidium adsorption on the surface of the topological insulator Bi$_2$Se$_3$ is found to induce a strong downward band bending, leading to the appearance of a quantum-confined two dimensional electron gas states (2DEGs) in the conduction band. The 2DEGs shows a strong Rashba-type spin-orbit splitting, and it has previously been pointed out that this has relevance to nano-scale spintronics devices. The adsorption of Rb atoms, on the other hand, renders the surface very reactive and exposure to oxygen leads to a rapid degrading of the 2DEGs. We show that intercalating the Rb atoms, presumably into the van der Waals gaps in the quintuple layer structure of Bi$_2$Se$_3$, drastically reduces the surface reactivity while not affecting the promising electronic structure. The intercalation process is observed above room temperature and accelerated with increasing initial Rb coverage, an effect that is ascribed to the Coulomb interaction between the charged Rb ions. Coulomb repulsion is also thought to be responsible for a uniform distribution of Rb on the surface.
description: 6 pages, 4 figures, ACS Nano, in press
Additional file 7 of Engineering of Trichoderma reesei for enhanced degradation of lignocellulosic biomass by truncation of the cellulase activator ACE3
Creators: name: Chen, Yumeng
name: Wu, Chuan
name: Fan, Xingjia
name: Zhao, Xinqing
name: Zhao, Xihua
name: Shen, Tao
name: Wei, Dongzhi
name: Wang, Wei
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer
subject: Plant Biology

description: Additional file 7: Table S1. Comparison of maximum cellulase activity and biomass production between PC-3-7 and PC-3-7-A723 after 240-h fed-batch fermentation in a 30-L fermenter.