cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of a soft back exoskeleton on lower lumbar spine loads during manual materials handling: a musculoskeletal modelling study
Creators: name: Favennec, Arthur
name: Moissenet, Florent
name: Frère, Julien
name: Mornieux, Guillaume
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The aim of this study was to append a passive soft back exoskeleton to a validated musculoskeletal model and assess its effectiveness in reducing lumbar loads. Fifteen participants lifted a box, with and without wearing a CORFOR® exoskeleton. A full body OpenSim model was used to estimate lumbar joint moments and reaction forces, as well as low back muscles forces. Wearing the exoskeleton reduced the peak flexion moment, muscles forces, as well as peak compressive and shear forces. This musculoskeletal modelling study shows that wearing the exoskeleton may reduce lumbar spine loads and may contribute to prevent low back disorders.
The role of redox and spontaneous potential in vertical mass transport of elements from mineralization in areas of thick glacial sedimentary cover
Creators: name: Hamilton, Stewart MacNaughton
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Geochemistry.

description: A recent theory implicated redox-gradients in vertical transport of elements from buried mineral deposits to surface soils and predicted the formation of 'reduced chimneys' in intervening overburden. This thesis tests that theory through surface and/or subsurface investigations at six sites; two host electronically conductive sulphide mineralization and four host non-conductive chemically reduced features including three kimberlites and an H2S-sourced 'forest ring.' Redox and spontaneous potential (SP) measurement techniques were developed and surveys carried out on surface and down-hole. Methods included: oxidation-reduction potential on groundwater and soil slurries; determination of H2S(aq)/SO42-(aq) in groundwater and O2(g) and CH4(g) in the headspace of wells; and a hybrid redox-SP method using both Pt and non-polarizable electrodes. The predicted 'reduced chimneys' were observed in overburden above mineralization. SP measurements demonstrate the presence of negative electrical anomalies over buried electronic conductors but positive responses over the non-conductors. It is proposed that strong redox gradients induce an electrical field, which results in mass transport of ions. Redox-active chemical species in a redox gradient are influenced by neighbouring species that are more electronegative on one side than the other. Redox-active polar ions and molecules should therefore exhibit a preferred orientation with their negative poles pointing in the positive redox direction, i.e. toward the neighbours with the strongest affinity for electrons. Alignment of constituent dipoles would result in a macroscopic polarity within the redox gradient and electrical anomalies that are negative at its oxidizing end. Since resistivity is finite, this electrical field should induce current in the form of an ion flux. The theory accounts for geochemical and electrical anomalies over buried mineralization in a variety of environments. It suggests that a negative SP response should develop above a buried, reduced feature if a redox gradient above it is positive-upward. However, where a reduced chimney extends to surface, the predominant redox gradient is horizontal and oxidizing-outward, which would induce a positive-inward electrical polarity and a positive SP response on surface above the feature. Buried electronic conductors are a special case in which the whole conductor polarizes in the positive-upward redox gradient of the shallow Earth's crust.
Endocrine Regulation Of Cognition And Neuroplasticity : Our Pursuit To Unveil The Complex Interaction Between Hormones, The Brain And Behaviour
Creators: name: Galea, Liisa A. M.
name: Uban, Kristina A.
name: Epp, Jonathan Richard
name: Brummelte, Susanne
name: Barha, Cindy K.
name: Wilson, Wendy L.
name: Lieblich, Stephanie E.
name: Pawluski, Jodi Lynn
Publisher: name: The University of British Columbia
Year: 2018

description: Gonadal and stress hormones modulate neuroplasticity and behaviour. This review focuses on our findings over the past decade on the effects of estrogens and androgens on hippocampal neurogenesis, hippocampus-dependent learning and memory and the effects of reproductive experience in the rodent. Briefly, evidence suggests that acute estradiol initially enhances and subsequently suppresses cell proliferation in the dentate gyrus of adult female rodents, but may have limited effects in male rodents. Intriguingly, repeated exposure to estradiol modulates hippocampal neurogenesis and cell death in adult female, but not male, rodents. Furthermore, testosterone and dihydrotestosterone upregulate hippocampal neurogenesis (via cell survival) in adult male rodents. We have found that estradiol can dose-dependently affect different brain regions that are involved in working memory (prefrontal cortex and hippocampus), reference memory (hippocampus) and conditioned place preference (amygdala). Pregnancy and motherhood differentially regulate adult hippocampal neurogenesis in the adult female rodent, with primiparous rats displaying lower levels of hippocampal cell proliferation and survival after parturition but better spatial working memory after weaning. These studies and others demonstrate that the female brain is organized differently and responds to steroid hormones differently than the male brain. It is of the upmost importance to investigate the effects on neuroplasticity and behaviour in both the male and the female, particularly when modelling diseases that exhibit sex differences in the incidence, etiology or treatment. This is especially important if we are to use our knowledge of how adult neurogenesis is regulated to develop strategies to repair neuron loss in neurodegenerative diseases such as Alzheimer’s disease and depression that exhibit clear sex differences.
title: Tätigkeitsbericht 2019 der vom RatSWD akkreditierten Forschungsdatenzentren (FDZ)
Creators: name: Rat Für Sozial- Und Wirtschaftsdaten (RatSWD)
Publisher: name: German Data Forum ( RatSWD)
Year: 2020

description: RatSWD Tätigkeitsberichte
Delineating the molecular basis of subtype-specific ligand binding, G protein coupling and signaling properties of D1 and D5 dopaminergic receptors
Creators: name: Iwasiow, Rafal M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Neuroscience.

description: Dopamine mediates its effects through the interaction with five distinct receptors that make up the D1-like (D1 and D5) and D2-like (D2, D3, and D4) families. Dopamine receptors are members of the heptahelical G protein-coupled receptor (GPCR) family. D1-like and D2-like receptors couple to the activation and inhibition of adenylyl cyclase, respectively. Dysfunction in dopaminergic signaling has been shown to contribute, among others to the etiology of Parkinson's disease, schizophrenia, and hypertension. The high degree of structural identity between D1 and D5 receptors has hampered the development of subtype-selective drugs. Despite the structural similarities, D1 and D5 receptor subtypes exhibit distinct ligand binding and G protein coupling properties. The objective of this thesis is to delineate the structural determinants involved in the distinct ligand binding and G protein coupling properties of D1 and D5 receptors Using chimeric and mutagenesis studies I demonstrate that differences in the primary sequence within the terminal receptor locus (a region encompassing TM6, third extracellular loop (EL3), TM7, and the cytoplasmic tail) are responsible for the functional differences of D1 and D5 receptors. I describe the EL3 domain as a key determinant in the binding of antipsychotic drugs (inverse agonists) and the agonist-mediated maximal activation of adenylyl cyclase. This study highlights a novel domain (EL3) regulating binding of inverse agonists at GPCRs. Furthermore, I describe a molecular interplay between TM6 and EL3 which mediates the subtype-specific phenotypes and activation of D1 and D5 receptors. In addition, I demonstrate that in spite of structural and functional similarities, D1-like receptors undergo a different regulatory pathway upon agonist stimulation. Specifically I demonstrate that the D5 receptor can undergo phosphorylation-independent desensitization and endocytosis. Overall, the work described in this thesis provides insight into the molecular basis of D1-like receptor signaling.
Calamanthus fuliginosus subsp. carteri Mathews
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Calamanthus
Calamanthus fuliginosus
Calamanthus fuliginosus carteri mathews

description: Calamanthus fuliginosus carteri Mathews
 Calamanthus fuliginosus carteri Mathews, 1912a: 337 (West Australia (Broome Hill)).
 Now Calamanthus montanellus Milligan, 1903. See Mayr, 1986b: 429, and Schodde and Mason, 1999: 152–153.
 HOLOTYPE: AMNH 587869, adult male, collected at Broomehill (5 Broome Hill), 33.51S, 117.38E (Johnstone and Storr, 2004: 504), Western Australia, Australia, on 1 November 1908, by Tom Carter. From the Mathews Collection (no. 2087) via the Rothschild Collection.
COMMENTS: Mathews cited his catalog number of the holotype in the original description. There are 10 specimens that I consider paratypes, all collected at Broomehill by Carter: AMNH 587870 (Mathews no. 2088), male, 3 November 1907 (not 1908, as in Mathews’ catalog); AMNH 587871 (2084), male, 1 November 1908; 587872 (2086), male, 17 August 1908; AMNH 587873 (2085), male, 24 August 1908; AMNH 587877 (2090), female, 28 August 1908; AMNH 587878 (2091), female, 1 November 1908; AMNH 587881 (2089), female, 3 November 1907 (not 1908, as in Mathews’ catalog); AMNH 587879 and 587880 are unsexed immature specimens collected on 1 November and represented in Mathews’ catalog by the joint number 2083; and AMNH 587882, an unsexed adult collected on 3 November 1907, apparently not entered in the catalog. Three additional specimens collected by Carter at Broomehill on 12 September 1910 are probable paratypes, but I did not find them in Mathews’ catalog.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on pages 143-144, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Prior sexual experience increases hippocampal cell proliferation and decreases risk assessment behavior in response to acute predator odor stress in the male rat
Creators: name: Spritzer, Mark D.
name: Weinberg, Alex
name: Viau, Victor
name: Galea, Liisa A. M.
Publisher: name: The University of British Columbia
Year: 2019

description: Acute exposure to the predator odor trimethyl thiazoline (TMT) induces defensive behaviour in the male rat, and this response is associated with a decrease in cell proliferation within the dentate gyrus of the hippocampus. Sexual experience appears to be protective, as it exerts anxiolytic-like effects and sustains gonadal function in the face of stress. To examine the influence of sexual experience on subsequent stress-induced defensive behaviour and cell proliferation in the hippocampus we exposed adult male rats to TMT odor with or without prior exposure to sexually receptive female rats. A subset of rats were injected with the DNA-synthesis marker bromodeoxyuridine (BrdU; 200mg/kg) during TMT exposure and perfused 24 h later to provide an index of cell proliferation within the dentate gyrus. In response to TMT, sexual experience reduced the duration of stretched attend postures, but had no significant effect on defensive burying. Furthermore, TMT induced a significant increase in cell proliferation in the dentate gyrus, but only in males with sexual experience. The results demonstrate an influence of socio-sexual experience on the magnitude of the behavioral and neural responses to predator odor stress.
Rétrospective BVH
Creators: name: Demonet, Marie-Luce
Publisher: name: Bibliothèques Virtuelles Humanistes. Zenodo
Year: 2024
Subjects: Recherche
SHS
Humanités numériques
Littérature française
Livre ancien
Histoire du Livre
XVIe
Renaissance
Histoire de l'imprimerie
Histoire des bibliothèques
Bibliothèque virtuelle
Edition numérique
XML-TEI
OCR
Montaigne
Rabelais
Patrimoine Ecrit
Biblissima
Biblissima+
Bases de données
Réseaux de recherche

description: Rétrospective par Marie-Luce Demonet, à l'occasion de l’assemblée générale 2023 du programme de recherche « Bibliothèques Virtuelles Humanistes » (CESR, Tours) et de l'anniversaire des 20 ans du programme BVH. Vendredi 24 novembre 2023, au Centre d’Études Supérieures de la Renaissance de Tours.
title: Opening up and Sharing Data from Qualitative Research: A Primer
Creators: name: Steinhardt, Isabel
name: Fischer, Caroline
name: Heimstädt, Maximilian
name: Hirsbrunner, Simon David
name: İkiz-Akıncı, Dilek
name: Kressin, Lisa
name: Kretzer, Susanne
name: Möllenkamp, Andreas
name: Porzelt, Maike
name: Rahal, Rima-Maria
name: Schimmler, Sonja
name: Wilke, René
name: Wünsche, Hannes
Publisher: name: German Data Forum ( RatSWD)
Year: 2021

description: RatSWD Working Paper Series
title: Understanding the Societal Impact of the Social Sciences and Humanities: Remarks on Roles, Challenges, and Expectations
Creators: name: Fecher, Benedikt
name: Kuper, Freia
name: Sokolovska, Nataliia
name: Fenton, Alex
name: Hornbostel, Stefan
name: Wagner, Gert G.
Publisher: name: German Data Forum ( RatSWD)
Year: 2021

description: RatSWD Working Paper Series
Oxidative fuel selection and muscle recruitment in shivering humans
Creators: name: Haman, Francois
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Animal Physiology.

description: During environmental cold exposure in adult humans, a decrease in core temperature can be prevented by increasing heat production (H˙ prod) via shivering thermogenesis. The main purpose of this thesis was to determine the effects of changes in carbohydrate (CHO) availability and shivering intensity on oxidative fuel selection and muscle recruitment during cold exposure. Using a combination of metabolic and electrophysiological approaches, fuel selection and EMG activity were quantified: (i) during low-intensity shivering (LOW) in individuals with normal (N), low (LO) and high CHO availability (HI), and (ii) during high-intensity shivering in individuals with normal CHO availability (HIGH). Low-intensity shivering (2.6-fold increase in H˙prod) resulted in a stimulation of plasma glucose (+138%), muscle glycogen (+109%) and lipids (+376%) oxidation rates for N (CHAPTER 2). Despite the observed increase in plasma glucose oxidation, this fuel only supplied 10% H˙ prod (or only 25% of all the glucose oxidized). Total heat production was therefore unequally shared between lipids (50%), muscle glycogen (30%), plasma glucose (10%)and proteins (10%). The same fuel selection measurements were then performed for LO and HI (CHAPTER 3). The size of CHO reserves had no effect on H˙prod, but had a major impact on fuel selection before and during shivering. In the cold, a complete shift was observed from lipid oxidation for LO (53%, 28% and 19% H˙prod for lipids, CHO and proteins, respectively) to CHO-based metabolism for HI (23%, 65% and 12% H˙prod for lipids, CHO and proteins, respectively). As for N, plasma glucose oxidation was a minor fuel source (<13% H˙ prod), falling to 7% H˙prod for LO. Therefore, plasma glucose oxidation did not compensate for changes in muscle glycogen oxidation and thus is not a strategy used for maintaining heat production. Instead, proteins and lipids compensated for the decreased in CHO availability. Most interestingly, these drastic changes in fuel metabolism were achieved without altering the electromyographic (EMG) signature of shivering muscles (CHAPTER 4). Results demonstrate that EMG shivering intensity, pattern and spectral components of eight large muscles remains unaffected by changes in fuel selection. Therefore, humans can sustain low thermogenic rates by oxidizing widely different fuel mixtures within the same muscle fibers. Considering the low metabolic rates reached during mild shivering (LOW), oxidative fuel utilization rates were then measured at higher shivering intensity (3.5-fold rise in H˙prod) to establish whether (i) the role of plasma glucose could be increased (CHAPTER 5) (ii) modifications of fuel selection could be achieved via the recruitment of fuel specific muscle fibers. (Abstract shortened by UMI.)
Realistic daily dynamics of olive and olive fly at 250 m resolution using cloud-gap-filled canopy temperature data from MODIS LST calibrated with MODIS NDVI
Creators: name: Ponti, Luigi
name: Gutierrez, Andrew Paul
name: Metz, Markus
name: Haas, Julia
name: Panzenböck, Elisabeth
name: Neteler, Markus
name: Baldacchino, Ferdinando
name: Ambrico, Alfredo
name: Baviello, Gerardo
name: Calvitti, Maurizio
name: Dell'Aquila, Alessandro
name: Calmanti, Sandro
name: Lampazzi, Elena
name: Miceli, Valerio
name: Cuna, Daniela
name: Stocchino, Federica
name: Carroccio, Davide
Publisher: name: Zenodo
Year: 2024

description: Poster and abstract presented at SUREDOS24 | Super - Resolution and Downscaling for EO and Earth Science29-31 May | ESRIN | Frascati, Italy | https://suredos24.esa.int/
title: Tätigkeitsbericht 2020 der vom RatSWD akkreditierten Forschungsdatenzentren (FDZ)
Creators: name: Rat Für Sozial- Und Wirtschaftsdaten (RatSWD)
Publisher: name: Rat für Sozial- und Wirtschaftsdaten (RatSWD)
Year: 2022

description: Tätigkeitsbericht
title: Sozialwissenschaftliche Forschungsdaten als historische Quellen: Welche Infrastrukturbedarfe hat die zeitgeschichtliche Forschung?
Creators: name: Zöller, Kathrin
name: Villinger, Clemens
name: Siegers, Pascal
name: Reh, Sabine
name: Raphael, Lutz
name: Von Hodenberg, Christina
name: Brückweh, Kerstin
Publisher: name: Rat für Sozial- und Wirtschaftsdaten (RatSWD)
Year: 2022

description: RatSWD Working Paper Series
Coffee Lectures Digitally - Coffee Lecture Online (UB Hildesheim)
Creators: name: Strauch, Annette
Publisher: name: Zenodo
Year: 2020
Subjects: Coffee Lectures
Forschungsdatenmanagement
Bibliotheken
Universitätsbibliotheken
Stiftung Universität Hildesheim
UB
Libraries
Schulungen im Forschungsdatenmanagement
Digitales Niedersachsen

description: During Corona, the Covid-19 pandemic, the Coffee Lectures dealing with Research Data Management have been a huge success so far with always around 80 people taking part.
title: Der Stand der Dinge zur forschungsethischen Begutachtung in den Geistes- und Sozialwissenschaften – Ergebnisse einer Umfrage unter Forschenden
Creators: name: Strobel, Anja
name: Zeiler, Anne Zeiler
name: Schaar, Katrin
Publisher: name: Rat für Sozial- und Wirtschaftsdaten (RatSWD)
Year: 2022

description: RatSWD Working Paper Series
The ability of boys with attention deficit hyperactivity disorder to process emotional information of varying complexity
Creators: name: Moore, Deborah M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Psychology, Clinical.

description: Since Lois Murphy (1937) reported that young preschool children demonstrate sympathetic responses to peers who are in distress, there has been a continuing investigation of two resulting fundamental questions: Are there stable individual differences in sympathetic responsiveness to another person's emotional state? And, by what mechanism do children come to feel the same emotion as another person or act appropriately in response to someone in distress? These questions have been approached by a number of contributors from various theoretical positions which this paper will review. Less represented in the growing body of literature regarding emotion is reference to the study of emotions with specific populations. This research examined the ability of boys with Attention Deficit Hyperactivity Disorder to process three types of emotional tasks which vary in terms of their respective degrees of complexity. Those tasks included the following: Facial Expression Identification; Emotion Statement Identification; and the partial administration of the Children's Apperceptive Story Telling test (CAST; Schneider, 1989). Boys with Attention Deficit Hyperactivity Disorder had significantly more difficulty on all three tasks. On the Facial Expression Identification Task, ADHD participants identified significantly fewer facial expressions than non ADHD participants. Phi Value for Facial Expression Identification was .35. ADHD students were significantly less accurate at Emotion Statement Identification. Moreover, the younger participants, particularly the younger ADHD participants, were significantly less accurate at Facial Expression Identification than their older counterparts. Eta values for group and grade main effects for the Emotion Statement Identification task .32 and .22 respectfully. The Cast Involved three measures, namely Positive Affect, Negative Affect, and Verbosity. The non ADHD group outperformed the ADHD group on all three measures. Eta values for group main effects for Positive Affect and Negative Affect were .84 and .75 respectively. Eta values for group and grade main effects for Verbosity were .67 and .28 respectively. Grade 8 boys with Attention Deficit Hyperactivity Disorder significantly outperformed their grade 4 counterparts on all three CAST tasks.
Building instructions: Electrode holder for in-vivo mechanical testing of the rat plantar flexors
Creators: name: Hinks, Avery
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 320905
subject: Neurology and neuromuscular diseases
classificationCode: 320802
subject: Human biophysics
classificationCode: 420701
subject: Biomechanics

description: Included here are the building instructions PDF containing a list of commercially available parts, as well as the STL files for the custom 3D-printed attachment which holds the electrodes.
КЕСИШ ПАЙТИДА ВИБРОАКУСТИК СИГНАЛЛАРНИ ҲОСИЛ БЎЛИШ ЖАРАЁНИНИ ТАХЛИЛИ
Creators: name: Тўхтасинов, Рустамбек
Publisher: name: Zenodo
Year: 2024

description: Ушбу тезисда  кесиш пайтида виброакустик сигналларни ҳосил бўлиш жараёнини таҳлили ҳакида маьлумотлар келтирилган.
Castration Differentially Affects Spatial Working and Reference Memory in Male Rats
Creators: name: Spritzer, Mark D.
name: Gill, Mandeep
name: Weinberg, Alex
name: Galea, Liisa A. M.
Publisher: name: The University of British Columbia
Year: 2019

description: A male advantage for spatial learning and memory tasks is well documented among humans and rodents. A possible physiological cause for this male advantage is activational effects of androgens among males. The spatial memory of 8 castrated and 8 sham-castrated adult male rats was compared using a working-reference memory version of the eight-arm radial arm maze followed by a reference memory version of the Morris water maze. After maze testing, blood was collected from each rat, and testosterone levels were determined using radioimmunoassay. In the radial arm maze, castrates committed significantly more working memory errors and significantly fewer reference memory errors than did shams. In the water maze, no statistically significant differences were found for acquisition or retention. There was a trend for shams with higher testosterone levels to have better retention in the water maze, but this seemed to be due to higher levels of perseverance rather than better reference memory. Castration may have affected performance in the radial arm maze but not the water maze because the radial arm maze was a more difficult task or because the water maze was aversively motivated while the radial arm maze was appetitively motivated. Our results indicate that androgens improve working memory and may impair reference memory, but the effects of androgens on reference memory seem to be task dependent.
title: Handreichung: Forschungsdatenzentren gründen.
Creators: name: Buck, Daniel
name: Croisier, Johannes
name: Eder, Christina
name: Hoffstätter, Ute
name: Jansen, Malte
name: Meyermann, Alexia
name: Siegers, Pascal
Publisher: name: Rat für Sozial- und Wirtschaftsdaten (RatSWD)
Year: 2022

description: RatSWD Working Paper Series
The cost effectiveness of early assessment and intervention by a dedicated health and social care professional team for older adults in the emergency department compared to treatment-as-usual: Economic evaluation of the OPTI-MEND trial
Creators: name: Trépel, Dominic
name: Ruiz‐Adame, Manuel
name: Cassarino, Marica
name: Ahern, Elayne
name: Devlin, Collette
name: Robinson, Katie
name: O'Shaughnessy, Íde
name: McCarthy, Gerard
name: Corcoran, Cian
name: Galvin, Rose
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background
Over 65s are frequent attenders to the Emergency Department (ED) and more than half are admitted for overnight stays. Early assessment and intervention by a dedicated ED-based Health and Social Care Professionals (HSCP) team reduces ED length of stay and the risk of hospital admissions among older adults while improving patient health-related quality-of-life and satisfaction with care. This study aims to evaluate whether augmenting the treatment as usual for older adults admitted to ED is cost-effective.
Methods and findings
Cost-effectiveness analysis (CEA), conducted alongside the OPTI-MEND randomised controlled trial of 353 patients aged ≥ 65 withlower urgency complaints compared the effectiveness of early assessment and intervention by a dedicated HSCP team in the ED to treatment as usual (TAU). An economic analysis estimated the average cost per older adults randomised to the HSCP team, and compared to TAU, how contact with HSCP team changed health care use, and associated total costs, and estimated the effect of HSCP on Quality-Adjusted Life Years (QALYs). Within the OPTI-MEND trial, the average cost of a contact with the HSCP team during ED attendance is estimated to be €801 per patient. Compared to TAU, the incremental QALY of intervention is 0.053 (95% CI: 0.023 to 0.0826, p<0.0001). Accounting for cost savings because of contact with HSCP team, the average incremental saving in the total cost, compared to TAU, is -€6,128 (95% CI: -€9,217 to -€3,038, p<0.0001). Given the incremental health gains and significant cost savings, bootstrapped cost CEA suggests that dedicated HSCP care dominates over TAU for low urgency older adults attending the ED.
Conclusions
A dedicated HSCP team in the ED significantly improves overall health for lower acuity older adults and, by reducing inpatient length of stay, results in staggering cost savings. This economic evaluation conducted on the OPTI-MEND trial provides convincing evidence that HSCP should be adopted as part of treatment as usual in Irish EDs
Prescription drug costs : BC versus Canada
Creators: name: Therapeutics Initiative (University Of British Columbia)
Publisher: name: The University of British Columbia
Year: 2023

description: Therapeutics Letter 72 highlights the findings that compare the cost of prescription drugs in British Columbia (BC) to Canada as a whole. We also summarize the therapeutic categories where BC physicians prescribe less than, equal to and more than the Canadian average. Conclusions: BC had the lowest per capita prescription drug costs in Canada in 2007. The rate of increase of drug spending in BC between 1998 and 2007 was the second lowest in Canada. Prescribing in BC for different therapeutic categories ranges from 41% below the national average to 13% above the national average. The reasons for the significantly higher prescription drug costs in the rest of Canada are not known, but it is clear that they are not associated with better health outcomes.
Evaluating the Development and Significance of Cloud Computing
Creators: name: Blessing, Elisha
name: Egon, Axel
name: Potter, Kaledio
name: Doris, Lucas
name: Yamaganti, Rohita
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 460601
subject: Cloud computing

description: Cloud computing has emerged as a transformative technology with profound implications for thedigital society. This paper aims to evaluate the development and significance of cloud computingand its impact on various aspects of society, including businesses, individuals, and governmentorganizations.The development of cloud computing can be attributed to advancements in internet infrastructure,virtualization technologies, and the increasing demand for scalable and cost-effective computingsolutions. Cloud computing offers a model for delivering computing resources, such as storage,processing power, and software applications, over the internet on a pay-as-you-go basis. Itenables users to access these resources from anywhere at any time, eliminating the need for on-premises infrastructure and reducing the barriers to entry for businesses and individuals.The significance of cloud computing lies in its transformative potential across multiple domains.In the business sector, cloud computing enables organizations to streamline their IT operations,achieve greater scalability, and reduce capital expenditures by shifting from traditional on-premises data centers to cloud-based infrastructure. This empowers businesses to focus on theircore competencies while leveraging the expertise and economies of scale offered by cloud serviceproviders.
title: Standardfragenkatalog zur Erhebung soziodemographischer und krisenbezogener Variablen
title: Erstellt von der Arbeitsgruppe des RatSWD zur Vernetzung sozialwissenschaftlicher Forschung in gesellschaftlichen Krisen
titleType: Subtitle
Creators: name: Rat Für Sozial- Und Wirtschaftsdaten (RatSWD)
Publisher: name: Rat für Sozial- und Wirtschaftsdaten (RatSWD)
Year: 2023

description: RatSWD Output Series
Calamanthus campestris subsp. dorrie Mathews 1912
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Calamanthus
Calamanthus campestris
Calamanthus campestris dorrie mathews

description: Calamanthus campestris dorrie Mathews
 Calamanthus campestris dorrie Mathews, 1912a: 337 (Dorrie Island, west Australia).
 Now Calamanthus campestris dorrie Mathews, 1912. See Mayr, 1986b: 429, and Schodde and Mason, 1999: 154–157.
 HOLOTYPE: AMNH 587957, adult male, collected on Dorré (5 Dorrie) Island, 25.09S, 113.11E (Times Atlas), Western Australia, Australia, on 15 August 1910. From the Mathews Collection (no. 7986) via the Rothschild Collection.
 COMMENTS: Mathews cited his catalog number of the holotype in the original description. Although he did not say how many specimens he examined, the holotype is the only specimen of dorrie that came to AMNH. He obtained it from the WAM and cataloged it on 16 March 1911; the number ‘‘10533’’ that appears on the field label may be a WAM number. In addition to the field label and the Mathews and Rothschild type labels, the specimen also bears a yellow ‘‘Figured’’ label, indicating that it was illustrated in Mathews (1922a: pl. 435, opp. p. 288, text p. 289), where it is confirmed as the type of dorrie.
Apparently, this specimen was collected by H.F.O. Lipfert, who collected on Bernier and Dorré islands in 1910 (R. Schodde, personal commun., and Whittell, 1954: 447). See Lipfert (1912) for an account of this trip.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 145, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Structural factors associated with an increased risk of HIV and sexually transmitted infection transmission among street-involved youth
Creators: name: Marshall, Brandon David Lewis
name: Kerr, Thomas
name: Shoveller, Jean
name: Montaner, Julio
name: Wood, Evan
Publisher: name: BioMed Central
Year: 2015

description: Background. The prevalence of HIV and sexually transmitted infections (STIs) among street-involved youth greatly exceed that of the general adolescent population; however, little is known regarding the structural factors that influence disease transmission risk among this population. Methods Between September 2005 and October 2006, 529 street-involved youth were enroled in a prospective cohort known as the At Risk Youth Study (ARYS). We examined structural factors associated with number of sex partners using quasi-Poisson regression and consistent condom use using logistic regression. Results At baseline, 415 (78.4%) were sexually active, of whom 253 (61.0%) reported multiple sex partners and 288 (69.4%) reported inconsistent condom use in the past six months. In multivariate analysis, self-reported barriers to health services were inversely associated with consistent condom use (adjusted odds ratio [aOR] = 0.52, 95%CI: 0.25 – 1.07). Structural factors that were associated with greater numbers of sex partners included homelessness (adjusted incidence rate ratio [aIRR] = 1.54, 95%CI: 1.11 – 2.14) and having an area restriction that affects access to services (aIRR = 2.32, 95%CI: 1.28 – 4.18). Being searched or detained by the police was significant for males (aIRR = 1.36, 95%CI: 1.02 – 1.81). Conclusion Although limited by its cross-sectional design, our study found several structural factors amenable to policy-level interventions independently associated with sexual risk behaviours. These findings imply that the criminalization and displacement of street-involved youth may increase the likelihood that youth will engage in sexual risk behaviours and exacerbate the negative impact of resultant health outcomes. Moreover, our findings indicate that environmental-structural interventions may help to reduce the burden of these diseases among street youth in urban settings.
Suenos y desencantos en novelas y peliculas cubanas del Periodo especial
Creators: name: Sarabia Acosta, Diana L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Literature, Modern.
subject: Literature, Latin American.
subject: Literature, Caribbean.
subject: Cinema.

description: En esta tesis se analizan tres novelas y dos peliculas cubanas publicadas durante el Periodo especial teniendo en cuenta los abordajes en relacion a los preceptos articulados en la narrativa institucional de la Revolucion y el dialogo que sostienen con el canon literario y filmico cubano que les precede. El corpus incluye las novelas Trilogia sucia de La Habana (1998), de Pedro Juan Gutierrez; Cien botellas en una pared (2002) de Ena Lucia Portela; Los palacios distantes (2002) de Abilio Estevez, y las peliculas Suite Habana (2003) de Fernando Perez y Miel para Oshun (2001) de Humberto Solas. En la indagacion se exploran tres topicos fundamentales: las nuevas respuestas al paradigma de Hombre nuevo, la representacion de las subjetividades lesbicas/homosexuales, y las recientes propuestas de nacion. Para el estudio de Trilogia sucia de La Habana , en el capitulo dos, se retorna el debate en torno a la posmodernidad, en concreto el planteamiento de Jean-Francois Lyotard sobre el debilitamiento de las metanarrativas y la emergencia de las "pequenas historias". En el marco de los desafios a los paradigmas de la modernidad el estudio de todas las obras presta atencion al cuestionamiento de las llamadas "identidades perdurables" y de las categorias identitarias de genero y raza en el contexto de los ideales revolucionarios en Cuba. El trabajo se nutre de los desafios planteados por academicas como Judith Butler a los esencialismos identitarios que categorizan los comportamientos y creencias ligados a la sexualidad bajo parametros que van de lo natural a lo perverso. Estas reflexiones contribuyen en el capitulo tres al estudio de la representacion de las subjetividades homosexual y lesbica en las novelas de Abilio Estevez y Ena Lucia Portela. En el capitulo cuatro se examinan dos formas de imaginar la nacion propuestas en las peliculas Miel para Oshun y Suite Habana. El nacionalismo se estudia, como lo sugiere Benedict Anderson, como un "artefacto cultural", es decir como el conjunto de creencias compartidas, en constante proceso de creacion e imaginacion, que transmiten una idea de unidad.
title: Entwicklung und Inbetriebnahme eines neuen Datenaufnahmesystems am QCLAM-Spektrometer
Creators: name: Singer, Maxim
Publisher: name: UNSPECIFIED
Year: 2020

description: Im Rahmen dieser Arbeit wurde zur Durchführung von kernphysikalischen Elektronenstreuexperimenten am supraleitenden Darmstädter Elektronenlinearbeschleuniger S-DALINAC ein neues Datenaufnahmesystem für das QCLAM-Spektrometer entwickelt und in Betrieb genommen. Dabei umfasste die Entwicklung die komplette Informationskette von den analogen Signalen der als Ortsdetektoren eingesetzten Vieldrahtdriftkammern bis zur grafischen Benutzeroberfläche zur Echtzeitüberwachung aller wichtiger Messgrößen während eines Elektronenstreuexperiments. Die Entwicklung der Datenaufnahme gliedert sich in drei Teile. Der erste Teil umfasst den Aufbau und Verschaltung, sowie die Hard- und Softwarekonfiguration von Elektronikmodulen. Dabei wurde die für das Starten der Datenaufnahme verantwortliche Trigger-Logik so aufgebaut, dass das Aufnehmen und Auslesen von Daten gleichzeitig stattfinden kann und die Experimentierzeit, die je nach Experiment mehrere Wochen dauern kann, im Vergleich zum vorherigen System effektiv um die Hälfte reduziert wird. Der zweite Teil der Datenaufnahme beinhaltet die Weiterverarbeitung von den binären Dateien aus den VME-Modulen. Dazu wurde ein umfangreiches Programm QCLAMon zur Echtzeitüberwachung und Darstellung von (e,e')-Daten während eines Experiments entwickelt. Dabei werden aus den gemessen Driftzeitinformationen für einzelne Ereignisse Elektronenbahnen rekonstruiert und nach notwendiger Korrektur der Spektrometer-Aberration mit zahlreichen Statistiken präsentiert. Die für die Korrekturen notwendigen Parameter wurden aus Kalibrierungsmessungen während mehrerer Teststrahlzeiten gewonnen. Der dritte Teil der Entwicklung umfasste die Inbetriebnahme des Spektrometers mit der neuen Datenaufnahme nach einer zehnjährigen Pause. Dazu wurde in Herbst 2018 eine Messkampagne zur Kalibrierung des Spektrometers durchgeführt. Dabei wurde die Fokalebene des Spektrometers für verschiedene Quadrupol-Dipolmagnetfeld-Einstellungen vermessen und eine Lochblendenmessung durchgeführt. Die daraus extrahierten Resultate wurden in das Analyseprogramm QCLAMon integriert. Damit konnte die relative Energieauflösung eines 12C-Anregungsspektrums auf 5⋅10^-4 erhöht werden, was dem besten jemals am QCLAM-Spektrometer gemessenen Wert entspricht. Durch eine Analyse des Strahlprofils auf dem Target mit optischer Übergangsstrahlung wurde gezeigt, dass die örtliche Schwankung des Strahlflecks einen messbaren Einfluss auf die erreichbare Energieauflösung hat und dass dieser Effekt korrigiert werden kann. Zudem wurde die Möglichkeit einer Strahlstrommessung mit optischer Übergangsstrahlung am QCLAM-Spektrometer untersucht.
title: Vernetzung sozialwissenschaftlicher Forschung in gesellschaftlichen Krisen - Koordinierungsinitiativen und Empfehlungen zur Datenharmonisierung
Creators: name: Rat Für Sozial-Und Wirtschaftsdaten (RatSWD)
Publisher: name: Rat für Sozial - und Wirtschaftsdaten (RatSWD)
Year: 2023

description: RatSWD Output Series
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
Creators: name: Kemmer, Danielle
name: McHardy, Lianne M.
name: Hoon, Shawn
name: Rebérioux, Delphine
name: Giaever, Guri
name: Nislow, Corey
name: Roskelley, Cal
name: Roberge, Michel
Publisher: name: BioMed Central
Year: 2015

description: Background: Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provide only a partial picture of the mechanism of action of a drug. Results Using the example of the tumor cell invasion inhibitor dihydromotuporamine C, we show that a more complete picture of drug action can be obtained by combining different chemical genomics approaches - analysis of the sensitivity of ρ 0 cells lacking mitochondrial DNA, drug-induced haploinsufficiency, suppression of drug sensitivity by gene overexpression and chemical-genetic synthetic lethality screening using strains deleted of nonessential genes. Killing of yeast by this chemical requires a functional mitochondrial electron-transport chain and cytochrome c heme lyase function. However, we find that it does not require genes associated with programmed cell death in yeast. The chemical also inhibits endocytosis and intracellular vesicle trafficking and interferes with vacuolar acidification in yeast and in human cancer cells. These effects can all be ascribed to inhibition of sphingolipid biosynthesis by dihydromotuporamine C. Conclusion Despite their similar conceptual basis, namely altering drug sensitivity by modifying gene dosage, each of the screening approaches provided a distinct set of information that, when integrated, revealed a more complete picture of the mechanism of action of a drug on cells.
Regulatory effects of peptides from the pro and catalytic domains of proprotein convertase subtilisinKexin9 (PCSK9) on low density lipoprotein receptor (LDLR)
Creators: name: Palmer, Heather
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) is the latest member of the PCSK enzyme family that is structurally related to the bacterial subtilisin and the yeast kexin. It plays a major role in the regulation of cholesterol by degrading low-density lipoprotein receptor (LDLR) responsible for the endocytosis of LDL-cholesterol. Thus, there is a great deal of research interest in the development of PCSK9 functional inhibitors which may have potential applications as therapeutic agents for lowering plasma LDL-cholesterol and the associated risk of cardiovascular disease. PCSK9 degrades LDLR by first binding to form a complex and then rerouting to the lysosomal compartment leading to its degradation. In addition it was shown that following the autocatalytic cleavage, the prodomain of PCSK9 remains strongly attached to the mature PCSK9 via its catalytic domain. Owing to these findings, we proposed that selected peptides from hPCSK9 pro and catalytic domains are likely to affect the LDLR binding. Using human hepatic HepG2 and Huh7 cells we showed that the acidic N-terminal and the mid-basic segments of the prodomain enhanced the LDLR protein level significantly, without altering the PCSK9 protein level. The physiologically relevant phoshpho-Ser47 peptide decreased the LDLR protein level suggesting that Ser47-phosphorylation leads to a gain of functional activity of PCSK9. Addition of recombinant PCSK9 to the culture medium decreased the LDLR protein level that was restored by the addition of PCSK931-40, 31-60 or 91-120 peptides. Two catalytic domain peptides PCSK9181-200 and PCSK9368-390 decreased LDLR content confirming their interactions with LDLR. Our study concludes that specific peptides from the pro- and catalytic domains of PCSK9 can regulate LDLR and may be useful for development of novel therapeutics for cholesterol regulation.
Katrin Fiedler: Wirtschaftsethik in China am Fallbeispiel von Shanghaier Protestanten. Zwischen Marx und Mammon
Creators: name: Gänßbauer, Monika
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 81 (2001): ASIEN (Oktober)
Calamanthus campestris subsp. hartogi Carter
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Calamanthus
Calamanthus campestris
Calamanthus campestris hartogi carter

description: Calamanthus campestris hartogi Carter
 Calamanthus campestris hartogi Carter, 1916: 6 (Dirk Hartog Island, West Australia).
 Now Calamanthus campestris hartogi Carter, 1916. See Mayr, 1986b: 429, and Schodde and Mason, 1999: 154–157.
HOLOTYPE: AMNH 587967, adult female, collected on Dirk Hartog Island, 25.50S, 113.03E (Johnstone and Storr, 2004: 506), Western Australia, Australia, on 18 May 1916, by Tom Carter. From the Mathews Collection via the Rothschild Collection.
 COMMENTS: In the original description, the type locality and deposition were given as ‘‘ Dirk Hartog Island, West Australia. In the Austral Avian Museum, Fairoak, Hants’’ (5 Mathews Collection). There are five specimens of this species from the Mathews Collection and collected by Carter on Dirk Hartog Island in 1916, three in April and May and two on 12 and 13 October. The meeting of the British Ornithologists’ Club at which this name was introduced was held 11 October 1916 (published on 24 October). Therefore, the latter two specimens collected on Carter’s second trip to the island (Carter and Mathews, 1917: 586) were not part of the type series. Of the remaining three, AMNH 587967 is marked ‘‘Type’’ and ‘‘hartogi’’ in Mathews’ hand. The description most closely matches this specimen also. The crown is more ‘‘tawny rufous’’ than that of the other specimens, and the soft parts colors of ‘‘Bill purple-brown; irides reddish yellow; feet and legs dark yellow’’ are closely matched by those recorded on the field label: ‘‘beak purple horn, eyes reddish yellow, feet and legs dark yellow brown’’. I consider this the holotype; it had not previously been included in AMNH type collection.
The two paratypes with their label data are as follows: AMNH 587964, adult male, collected on 24 April 1916, beak blackish purple, eyes reddish yellow, feet and legs brownish purple; and AMNH 587966, adult male, collected on 22 May 1916, beak purple horn, eyes bright yellow, feet and legs fleshy brown.
 Mayr (1986b: 429) considered hartogi a synonym of C. c. dorrie.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 145, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
La célérité de la justice militaire canadienne: Vers un meilleur équilibre entre efficacité et équité
Creators: name: Lévesque, Pascal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Law.

description: Selon une approche classique avec des éléments de droit comparé, l'auteur tente de trouver un meilleur équilibre entre efficacité et équité en justice militaire canadienne en défendant la thèse qu'on peut améliorer les deux à la fois. Remontant dans une première partie aux sources du droit militaire anglo-américain pour saisir le poids de l'histoire, l'auteur montre comment la justice militaire canadienne est passée d'un système expéditif soumis aux impératifs de la chaîne de commandement à un système équitable mais plus lent. Favorisant la protection des droits de la personne, l'auteur justifie la nécessité de calibrer à nouveau le système malgré la législation en place. Dans une seconde partie, l'auteur propose une série de mesures législatives comme administratives visant à prévenir, de l'enquête au procès, les délais indus et leurs conséquences néfastes tout en rehaussant l'équité par l'augmentation de la capacité d'intervention des juges militaires, lesquels seraient investis de nouveaux pouvoirs au sein d'une cour martiale permanente.