cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multiple Field Ultra Slow Roll Inflation: Primordial Black Holes From Straight Bulk And Distorted Boundary
Creators: name: Hooshangi, Sina
name: Talebian, Alireza
name: Namjoo, Mohammad Hossein
name: Firouzjahi, Hassan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study a model of two-field ultra-slow-roll (USR) inflation bounded by a curve in the field space. Curvature perturbations and non-Gaussianities can be enhanced both during the USR phase and from the inhomogeneities at the boundary. We employ the full non-linear $δN$ formalism to calculate the probability distribution function (PDF) for curvature perturbation non-perturbatively and show that the non-linear effects can significantly enhance the abundance of the primordial black holes (PBHs). For large curvature perturbations, the PDF has a universal exponential tail, but for the intermediate values, the PDF -- and, therefore, the abundance of the PBHs -- depend sensitively on the geometry of the boundary.
description: 9 pages, 5 figures, V2: matches the published version
Light absorption enhancement of perovskite solar cells by a modified anti-reflection layer with corrugated void-like nanostructure using finite difference time domain methods
Creators: name: Mulyanti, Budi
name: Anwar, Muhammad Raihan
name: Wulandari, Chandra
name: Hasanah, Lilik
name: Pawinanto, Roer Eka
name: Hamidah, Ida
name: Rusydi, Andrivo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Perovskite solar cells (PSC) have become a growing research interest due to their flexibility, attractive properties, and low production cost. However, the thin-film structure of PSC often results in a not fully absorbed incident light by the active layer, which is crucial to determine PSC efficiency. Thus, the fabrication of an active layer with unique nanostructures is often used to enhance light absorption and general PSC efficiency. Using the theoretical simulation based-on Finite-Difference Time-Domain (FDTD) technique, this work demonstrates the successful improvement of light absorption by embedding corrugated void-like structure and perovskite thickness modification. The investigation of a corrugated void-type anti-reflection layer effect on light absorption is done by modifying the radius (r) and lattice constant (a) to obtain the optimum geometry. In addition, the MAPbI3 perovskite layer thickness is also adjusted to examine the optimum light absorption within the visible length to nearinfrared. The theoretical calculations show that the optimum r=692 nmand a=776 nm. Meanwhile, the optimum absorber layer thickness is 750 nm. Compared to flat PSC, our proposed PSC absorbed more light, especially in the near-infrared region. Our result shows demonstrates the successful enhancement of light absorption by embedding corrugated void-like structure and modifying the perovskite thickness using a theoretical simulation based on theFDTD technique.
Birefringence of Single and Bundled Microtubules
Creators: name: Salmon, E. D.
name: Tran, P. T.
name: Oldenbourg, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: We have measured the birefringence of microtubules (MTs) and of MT-based macromolecular assemblies in vitro and in living cells by using the new Pol-Scope. A single microtubule in aqueous suspension and imaged with a numerical aperture of 1.4 had a peak retardance of 0.07 nm. The peak retardance of a small bundle increased linearly with the number of MTs in the bundle. Axonemes (prepared from sea urchin sperm) had a peak retardance 20 times higher than that of single MTs, in accordance with the nine doublets and two singlets arrangement of parallel MTs in the axoneme. Measured filament retardance decreased when the filament was defocused or the numerical aperture of the imaging system was decreased. However, the retardance "area," which we defined as the image retardance integrated along a line perpendicular to the filament axis, proved to be independent of focus and of numerical aperture. These results are in good agreement with a theory that we developed for measuring retardances with imaging optics. Our theoretical concept is based on Wiener's theory of mixed dielectrics, which is well established for nonimaging applications. We extend its use to imaging systems by considering the coherence region defined by the optical set-up. Light scattered from within that region interferes coherently in the image point. The presence of a filament in the coherence region leads to a polarization dependent scattering cross section and to a finite retardance measured in the image point. Similar to resolution measurements, the linear dimension of the coherence region for retardance measurements is on the order lambda/(2 NA), where lambda is the wavelength of light and NA is the numerical aperture of the illumination and imaging lenses.
Approximation approach to the fractional BVP with the Dirichlet type boundary conditions
Creators: name: Marynets, Kateryna
name: Pantova, Dona
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We use a numerical-analytic technique to construct a sequence of successive approximations to the solution of a system of fractional differential equations, subject to Dirichlet boundary conditions. We prove the uniform convergence of the sequence of approximations to a limit function, which is the unique solution to the boundary value problem under consideration, and give necessary and sufficient conditions for the existence of solutions. The obtained theoretical results are confirmed by a model example.
Supplementary document for Multimodal Imaging of Metabolic Activities for Distinguishing Subtypes of Breast Cancer - 6641024.pdf
Creators: name: LI, ZHI
name: Nguyen, Chloe
name: Jang, Hongje
name: Hoang, David
name: Min, SoeSu
name: Ackerstaff, Ellen
name: koutcher, jason
name: Shi, Lingyan
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplimental Documents
(101507) Mary Ellen Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SL Sensor: An Open-Source, ROS-Based, Real-Time Structured Light Sensor for High Accuracy Construction Robotic Applications
Creators: name: Lam, Teng Foong
name: Blum, Hermann
name: Siegwart, Roland
name: Gawel, Abel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: High accuracy 3D surface information is required for many construction robotics tasks such as automated cement polishing or robotic plaster spraying. However, consumer-grade depth cameras currently found in the market are not accurate enough for these tasks where millimeter (mm)-level accuracy is required. This paper presents SL Sensor, a structured light sensing solution capable of producing high fidelity point clouds at 5 Hz by leveraging on phase shifting profilometry (PSP) codification techniques. The SL Sensor was compared with to two commercial depth cameras - the Azure Kinect and RealSense L515. Experiments showed that the SL Sensor surpasses the two devices in both precision and accuracy for indoor surface reconstruction applications. Furthermore, to demonstrate SL Sensor's ability to be a structured light sensing research platform for robotic applications, a motion compensation strategy was developed that allows the SL Sensor to operate during linear motion when traditional PSP methods only work when the sensor is static. Field experiments show that the SL Sensor is able to produce highly detailed reconstructions of spray plastered surfaces. The robot operating system (ROS)-based software and a sample hardware build of the SL Sensor are made open-source with the objective to make structured light sensing more accessible to the construction robotics community. All documentation and code is available at https://github.com/ethz-asl/sl_sensor/ .
How Microtubules Get Fluorescent Speckles
Creators: name: Waterman-Storer, Clare M.
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The dynamics of microtubules in living cells can be seen by fluorescence microscopy when fluorescently labeled tubulin is microinjected into cells, mixing with the cellular tubulin pool and incorporating into microtubules. The subsequent fluorescence distribution along microtubules can appear "speckled" in high-resolution images obtained with a cooled CCD camera (Waterman-Storer and Salmon, 1997. J. Cell Biol. 139:417-434). In this paper we investigate the origins of these fluorescent speckles. In vivo microtubules exhibited a random pattern of speckles for different microtubules and different regions of an individual microtubule. The speckle pattern changed only after microtubule shortening and regrowth. Microtubules assembled from mixtures of labeled and unlabeled pure tubulin in vitro also exhibited fluorescent speckles, demonstrating that cellular factors or organelles do not contribute to the speckle pattern. Speckle contrast (measured as the standard deviation of fluorescence intensity along the microtubule divided by the mean fluorescence intensity) decreased as the fraction of labeled tubulin increased, and it was not altered by the binding of purified brain microtubule-associated proteins. Computer simulation of microtubule assembly with labeled and unlabeled tubulin showed that the speckle patterns can be explained solely by the stochastic nature of tubulin dimer association with a growing end. Speckle patterns can provide fiduciary marks in the microtubule lattice for motility studies or can be used to determine the fraction of labeled tubulin microinjected into living cells.
Topological Molecules and Topological Localization of a Rydberg Electron on a Classical Orbit
Creators: name: Kopaei, Ali Emami
name: Tian, Xuedong
name: Giergiel, Krzysztof
name: Sacha, Krzysztof
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: It is common knowledge that atoms can form molecules if they attract each other. Here, we show that it is possible to create molecules where bound states of the atoms are not the result of attractive interactions but have the topological origin. That is, the bound states of the atoms correspond to the topologically protected edge states of a topological model. Such topological molecules can be realized if the interaction strength between ultra-cold atoms is properly modulated in time. A similar mechanism allows one to realize topologically protected localization of an electron on a classical orbit if a Rydberg atom is perturbed by a properly modulated microwave field.
description: 5 pages, 3 figures + supplemental materials, improved version
Local Measurements of Viscoelastic Parameters of Adherent Cell Surfaces by Magnetic Bead Microrheometry
Creators: name: Sackmann, Erich
name: Jacobson, Ken
name: Ziemann, Florian
name: Boulbitch, Alexei A.
name: Bausch, Andreas R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: A magnetic bead microrheometer has been designed which allows the generation of forces up to 10(4) pN on 4.5 micron paramagnetic beads. It is applied to measure local viscoelastic properties of the surface of adhering fibroblasts. Creep response and relaxation curves evoked by tangential force pulses of 500-2500 pN (and approximately 1 s duration) on the magnetic beads fixed to the integrin receptors of the cell membrane are recorded by particle tracking. Linear three-phasic creep responses consisting of an elastic deflection, a stress relaxation, and a viscous flow are established. The viscoelastic response curves are analyzed in terms of a series arrangement of a dashpot and a Voigt body, which allows characterization of the viscoelastic behavior of the adhering cell surface in terms of three parameters: an effective elastic constant, a viscosity, and a relaxation time. The displacement field generated by the local tangential forces on the cell surface is visualized by observing the induced motion of assemblies of nonmagnetic colloidal probes fixed to the membrane. It is found that the displacement field decays rapidly with the distance from the magnetic bead. A cutoff radius of Rc approximately 7 micron of the screened elastic field is established. Partial penetration of the shear field into the cytoplasm is established by observing the induced deflection of intracellular compartments. The cell membrane was modeled as a thin elastic plate of shear modulus mu * coupled to a viscoelastic layer, which is fixed to a solid support on the opposite side; the former accounts for the membrane/actin cortex, and the latter for the contribution of the cytoskeleton to the deformation of the cell envelope. It is characterized by the coupling constant chi characterizing the elasticity of the cytoskeleton. The coupling constant chi and the surface shear modulus mu * are obtained from the measured displacements of the magnetic and nonmagnetic beads. By analyzing the experimental data in terms of this model a surface shear modulus of mu * approximately 2 . 10(-3) Pa m to 4 . 10(-3) Pa m is found. By assuming an approximate plate thickness of 0.1 micron one estimates an average bulk shear modulus of mu approximately (2 / 4) . 10(-4) Pa, which is in reasonable agreement with data obtained by atomic force microscopy. The viscosity of the dashpot is related to the apparent viscosity of the cytoplasm, which is obtained by assuming that the top membrane is coupled to the bottom (fixed) membrane by a viscous medium. By application of the theory of diffusion of membrane proteins in supported membranes we find a coefficient of friction of bc approximately 2 . 10(9) Pa s/m corresponding to a cytoplasmic viscosity of 2 . 10(3) Pa s.
Origins of Individual Swimming Behavior in Bacteria
Creators: name: Bourret, Robert B.
name: Bray, Dennis
name: Abouhamad, Walid N.
name: Morton-Firth, Carl J.
name: Levin, Matthew D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Cells in a cloned population of coliform bacteria exhibit a wide range of swimming behaviors--a form of non-genetic individuality. We used computer models to examine the proposition that these variations are due to differences in the number of chemotaxis signaling molecules from one cell to the next. Simulations were run in which the concentrations of seven gene products in the chemotaxis pathway were changed either deterministically or stochastically, with the changes derived from independent normal distributions. Computer models with two adaptation mechanisms were compared with experimental results from observations on individuals drawn from genetically identical populations. The range of swimming behavior predicted for cells with a standard deviation of protein copy number per cell of 10% of the mean was found to match closely the experimental range of the wild-type population. We also make predictions for the swimming behaviors of mutant strains lacking the adaptational mechanism that can be tested experimentally.
(101506) Lionel Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Tripartite entanglement in quantum memristors
Creators: name: Kumar, S.
name: Cárdenas-López, F. A.
name: Hegade, N. N.
name: Albarrán-Arriagada, F.
name: Solano, E.
name: Barrios, G. Alvarado
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the entanglement and memristive properties of three coupled quantum memristors. We consider quantum memristors based on superconducting asymmetric SQUID architectures which are coupled via inductors. The three quantum memristors are arranged in two different geometries: linear and triangular coupling configurations. We obtain a variety of correlation measures, including bipartite entanglement and tripartite negativity. We find that, for identical quantum memristors, entanglement and memristivity follow the same behavior for the triangular case and the opposite one in the linear case. Finally, we study the multipartite correlations with the tripartite negativity and entanglement monogamy relations, showing that our system has genuine tripartite entanglement. Our results show that quantum correlations in multipartite memristive systems have a non-trivial role and can be used to design quantum memristor arrays for quantum neural networks and neuromorphic quantum computing architectures.
description: 9 pages, 6 figures
Quantitative Fluorescence Resonance Energy Transfer Measurements Using Fluorescence Microscopy
Creators: name: Liang, Xiao Huan
name: Gordon, Gerald W.
name: Herman, Brian
name: Berry, Gail
name: Levine, Beth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Fluorescence resonance energy transfer (FRET) is a technique used for quantifying the distance between two molecules conjugated to different fluorophores. By combining optical microscopy with FRET it is possible to obtain quantitative temporal and spatial information about the binding and interaction of proteins, lipids, enzymes, DNA, and RNA in vivo. In conjunction with the recent development of a variety of mutant green fluorescent proteins (mtGFPs), FRET microscopy provides the potential to measure the interaction of intracellular molecular species in intact living cells where the donor and acceptor fluorophores are actually part of the molecules themselves. However, steady-state FRET microscopy measurements can suffer from several sources of distortion, which need to be corrected. These include direct excitation of the acceptor at the donor excitation wavelengths and the dependence of FRET on the concentration of acceptor. We present a simple method for the analysis of FRET data obtained with standard filter sets in a fluorescence microscope. This method is corrected for cross talk (any detection of donor fluorescence with the acceptor emission filter and any detection of acceptor fluorescence with the donor emission filter), and for the dependence of FRET on the concentrations of the donor and acceptor. Measurements of the interaction of the proteins Bcl-2 and Beclin (a recently identified Bcl-2 interacting protein located on chromosome 17q21), are shown to document the accuracy of this approach for correction of donor and acceptor concentrations, and cross talk between the different filter units.
Peter Haupt, Römische Münzhorte des 3. Jhs. in Gallien und den germanischen Provinzen
Creators: name: Kaenel, Hans-Markus Von
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Rezension zu: Peter Haupt, Römische Münzhorte des 3. Jhs. in Gallien und den germanischen Provinzen. Eine Studie zu archäologischen Aspekten der Entstehung, Verbergung und Auffindung von Münzhorten. Provinzialrömische Studien Bd. 1. Verlag Bernhard Albert Greiner, Grunbach 2001. 42,— €. ISBN 3-935383-07-X. ISSN 1617-934X. 305 Seiten mit 65 Karten, 8 Diagrammen und 11 Tabellen.
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 84 Nr. 2 (2006)
On generally covariant mathematical formulation of Feynman integral in Lorentz signature
Creators: name: Laszlo, Andras
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 83C47 (Primary), 46A03 (Secondary)

description: It is widely accepted that the Feynman integral is one of the most promising methodologies for defining a generally covariant formulation of nonperturbative interacting quantum field theories (QFTs) without a fixed prearranged causal background. Recent literature suggests that if the spacetime metric is not fixed, e.g. because it is to be quantized along with the other fields, one may not be able to avoid considering the Feynman integral in the original Lorentz signature, without Wick rotation. Several mathematical phenomena are known, however, which are at some point showstoppers to a mathematically sound definition of Feynman integral in Lorentz signature. The Feynman integral formulation, however, is known to have a differential reformulation, called to be the master Dyson--Schwinger (MDS) equation for the field correlators. In this paper it is shown that a particular presentation of the MDS equation can be cast into a mathematically rigorously defined form: the involved function spaces and operators can be strictly defined and their properties can be established. Therefore, MDS equation can serve as a substitute for the Feynman integral, in a mathematically sound formulation of constructive QFT, in arbitrary signature, without a fixed background causal structure. It is also shown that even in such a generally covariant setting, there is a canonical way to define the Wilsonian regularization of the MDS equation. The main result of the paper is a necessary and sufficient condition for the regularized MDS solution space to be nonempty, for conformally invariant Lagrangians. This theorem also provides an iterative approximation algorithm for obtaining regularized MDS solutions, and is guaranteed to be convergent whenever the solution space is nonempty. The algorithm could eventually serve as a method for putting Lorentz signature QFTs onto lattice, in the original metric signature.
description: 28 pages + appendix and supplementary material about topological vector spaces; final published version
Thermal Behavior of Astrophysical Amorphous Molecular Ices
Creators: name: Gudipati, Murthy S.
name: Fleury, Benjamin
name: Wagner, Robert
name: Henderson, Bryana L.
name: Altwegg, Kathrin
name: Rubin, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Ice is a major component of astrophysical environment - from interstellar molecular clouds through protoplanetary disks to evolved solar systems. Ice and complex organic matter coexist in these environments as well, and it is thought primordial ice brought the molecules of life to Earth four billion years ago, which could have kickstarted the origin of life on Earth. To understand the journey of ice and organics from their origins to becoming a part of evolved planetary systems, it is important to complement high spatial and spectral resolution telescopes such as JWST with laboratory experimental studies that provide deeper insight into the processes that occur in these astrophysical environments. Our laboratory studies are aimed at providing this knowledge. In this article we present simultaneous mass spectrometric and infrared spectroscopic investigation on how molecular ice mixtures behave at different temperatures and how this information is critical to interpret observational data from protoplanetary disks as well as comets. We find that amorphous to crystalline water ice transformation is the most critical phenomenon that differentiates between outgassing of trapped volatiles such as CO2 vs. outgassing of pure molecular ice domains of the same in a mixed molecular ice. Crystalline water ice is found to trap only a small fraction of other volatiles (<5%), indicating ice grain composition in astrophysical and planetary environments must be different depending on whether the ice is in amorphous phase or transformed into crystalline phase, even if the crystalline ice undergoes radiation-induced amorphization subsequently. Crystallization of water ice is a key differentiator for many ices in astronomical environments as well as in our Solar System.
description: Published in Royal Society of Chemistry Faraday Discussions, 2023
(101505) Henry Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Small black holes in global AdS spacetime
Creators: name: Jokela, Niko
name: Pönni, Arttu
name: Vuorinen, Aleksi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study finite temperature correlation functions and quasinormal modes in a strongly coupled conformal field theory holographically dual to a small black hole in global Anti-de Sitter spacetime. Upon variation of the black hole radius, our results smoothly interpolate between known limits corresponding to large black holes and thermal AdS space. This implies that the quantities are continuous functions of energy density in the microcanonical ensemble, thus smoothly connecting the deconfined and confined phases that are separated by a first order phase transition in the canonical description.
description: 5 pages, 5 figures. v2: Additional discussion and references, one new figure
Regulation of Cardiac Muscle Ca 2+ Release Channel by Sarcoplasmic Reticulum Lumenal Ca 2+
Creators: name: Xu, Le
name: Meissner, Gerhard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The cardiac muscle sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor) is a ligand-gated channel that is activated by micromolar cytoplasmic Ca2+ concentrations and inactivated by millimolar cytoplasmic Ca2+ concentrations. The effects of sarcoplasmic reticulum lumenal Ca2+ on the purified release channel were examined in single channel measurements using the planar lipid bilayer method. In the presence of caffeine and nanomolar cytosolic Ca2+ concentrations, lumenal-to-cytosolic Ca2+ fluxes >/=0.25 pA activated the channel. At the maximally activating cytosolic Ca2+ concentration of 4 microM, lumenal Ca2+ fluxes of 8 pA and greater caused a decline in channel activity. Lumenal Ca2+ fluxes primarily increased channel activity by increasing the duration of mean open times. Addition of the fast Ca2+-complexing buffer 1,2-bis(2-aminophenoxy)ethanetetraacetic acid (BAPTA) to the cytosolic side of the bilayer increased lumenal Ca2+-activated channel activities, suggesting that it lowered Ca2+ concentrations at cytosolic Ca2+-inactivating sites. Regulation of channel activities by lumenal Ca2+ could be also observed in the absence of caffeine and in the presence of 5 mM MgATP. These results suggest that lumenal Ca2+ can regulate cardiac Ca2+ release channel activity by passing through the open channel and binding to the channel's cytosolic Ca2+ activation and inactivation sites.
New age-metallicity diagnostic diagram for the Washington photometric system
Creators: name: Piatti, Andrés E.
name: Perren, Gabriel I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The age calibration of the Washington deltaT1 index is mainly used to estimate ages of star clusters older than 1 Gyr, no age-metallicity degeneracy effect is considered. We have profusely exploited synthetic T1 versus C-T1 colour magnitude diagrams aiming at exploring the intrinsic behaviour of the deltaT1 index. The analysis shows that deltaT1 varies with age and metal content as well. In general, the dependence on age weakens for ages greater than ~ 6 Gyr, and results even less sensitive to age as the metallicity decreases. For ages younger than ~ 5 Gyr deltaT1 shows a strong correlation with both age and metallicity. The deltaC index -defined as deltaT1 for the C passband- is also a combined measurement of age and metallicity. We introduce a new age-metallicity diagnostic diagram, deltaT1 versus deltaC - deltaT1, which has shown the ability of unambiguously providing age and metallicity estimates, simultaneously. The new procedure allows to derive ages from 1 up to 13 Gyr and metallicities [Fe/H] from -2.0 up to +0.5 dex, and is independent of the cluster reddening and distance modulus. It does solve the constraints found in the deltaT1 index and surpasses the performance of the standard giant branch metallicity method. All these features make the diagnostic diagram a powerful tool for estimating accurate ages as well as metallicities.
description: 14 pages, 7 figures, accepted for publication in MNRAS
(101504) Hannah Board
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Role of Hydrophobicity and Solvent-Mediated Charge-Charge Interactions in Stabilizing α -Helices
Creators: name: Ripoll, Daniel R.
name: Villegas, Myriam E.
name: Vorobjev, Yuri N.
name: Vila, Jorge A.
name: Scheraga, Harold A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: A theoretical study to identify the conformational preferences of lysine-based oligopeptides has been carried out. The solvation free energy and free energy of ionization of the oligopeptides have been calculated by using a fast multigrid boundary element method that considers the coupling between the conformation of the molecule and the ionization equilibria explicitly, at a given pH value. It has been found experimentally that isolated alanine and lysine residues have somewhat small intrinsic helix-forming tendencies; however, results from these simulations indicate that conformations containing right-handed alpha-helical turns are energetically favorable at low values of pH for lysine-based oligopeptides. Also, unusual patterns of interactions among lysine side chains with large hydrophobic contacts and close proximity (5-6 A) between charged NH3+ groups are observed. Similar arrangements of charged groups have been seen for lysine and arginine residues in experimentally determined structures of proteins available from the Protein Data Bank. The lowest-free-energy conformation of the sequence Ac-(LYS)6-NMe from these simulations showed large pKalpha shifts for some of the NH3+ groups of the lysine residues. Such large effects are not observed in the lowest-energy conformations of oligopeptide sequences with two, three, or four lysine residues. Calculations on the sequence Ac-LYS-(ALA)4-LYS-NMe also reveal low-energy alpha-helical conformations with interactions of one of the LYS side chains with the helix backbone in an arrangement quite similar to the one described recently by (Proc. Natl. Acad. Sci. U.S.A. 93:4025-4029). The results of this study provide a sound basis with which to discuss the nature of the interactions, such as hydrophobicity, charge-charge interaction, and solvent polarization effects, that stabilize right-handed alpha-helical conformations.
Does seeing nature through a spiritual “lens” lead to moral concern for nature & greater well-being: A study using a novel photography task
Creators: name: Billet, Matthew
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: This study investigates the causal link between ecospirituality (seeing and experience nature’s spiritual qualities) and two constructs of widespread importance: Moral concern for nature and well-being. We use a novel photography task that encourages participants to see nature through different “lenses” and assess the impact of this intervention on our two key constructs. Three conditions are designed to isolate the effect of ecospirituality from other positive views of nature and spiritual views of non-nature objects, like architecture.
(101503) William Ormerod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structural Mosaicism on the Submicron Scale in the Plasma Membrane
Creators: name: Walsh, Frank S.
name: Yang, Bing
name: Doherty, Patrick
name: Jacobson, Ken A.
name: Moore, Stephen E.
name: Simson, Rudolf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The lateral mobility of the neural cell adhesion molecule (NCAM) was examined using single particle tracking (SPT). Various isoforms of human NCAM, differing in their ectodomain, their membrane anchorage mode, or the size of their cytoplasmic domain, were expressed in National Institutes of Health 3T3 cells and C2C12 muscle cells. On a 6.6-s time scale, SPT measurements on both transmembrane and glycosylphosphatidylinositol (GPI) anchored isoforms of NCAM expressed in 3T3 cells could be classified into mobile (Brownian diffusion), slow diffusion, corralled diffusion, and immobile subpopulations. On a 90-s time scale, SPT studies in C2C12 cells revealed that 40-60% of transfected NCAM was mobile, whereas a smaller fraction (approximately 10-30%) experienced much slower diffusion. In addition, a fraction of approximately 30% of both transfected GPI and transmembrane isoforms and endogenous NCAM isoforms in C2C12 cells experienced transient confinement for approximately 8 s within regions of approximately 300-nm diameter. Diffusion within both these and the slow diffusion regions was anomalous, consistent with movements through a dense field of obstacles, whereas diffusion outside these regions was normal. Thus the membrane appears as a mosaic containing regions that permit free diffusion as well as regions in which NCAM is transiently confined to small or more extended domains. These results, including a large, freely diffusing fraction, similar confinement of transmembrane and GPI isoforms, a significant slowly diffusing fraction, and relatively large interdomain distances, are at some variance with the membrane skeleton fence model (Kusumi and Sako, 1996). Possible revisions to the model that incorporate these data are discussed.
(101502) Elizabeth Collacot
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Stratification of arrhythmic risk in HCM patients on the basis of oedema and myocardial scar on late gadolinium enhancement-cardiac magnetic resonance (LGE-CMR): a 11-year follow-up study
Creators: name: Bertugno, Serena
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Contrast agents
subject: MR
subject: Contrast agent-intravenous
subject: Computer Applications-Detection, diagnosis
subject: Hyperplasia / Hypertrophy
subject: Oedema

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Hypertrophic Cardiomyopathy (HCM) is a complex and fairly frequent familiarcardiac disease (1:500), characterized by extreme heterogeneity with respect to genetic, phenotypic and clinical expression and pathophysiological substrates [1]. Clinical...
Searching in HI for Massive Low Surface Brightness Galaxies: Samples from HyperLeda and the UGC
Creators: name: O'Neil, K.
name: Schneider, Stephan E.
name: van Driel, W.
name: Liu, G.
name: Joseph, T.
name: Schwortz, A. C.
name: Butcher, Z.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A search has been made for 21 cm HI line emission in a total of 350 unique galaxies from two samples whose optical properties indicate they may be massive The first consists of 241 low surface brightness (LSB) galaxies of morphological type Sb and later selected from the HyperLeda database and the the second consists of 119 LSB galaxies from the UGC with morphological types Sd-m and later. Of the 350 unique galaxies, 239 were observed at the Nancay Radio Telescope, 161 at the Green Bank Telescope, and 66 at the Arecibo telescope. A total of 295 (84.3%) were detected, of which 253 (72.3%) appear to be uncontaminated by any other galaxies within the telescope beam. Finally, of the total detected, uncontaminated galaxies, at least 31 appear to be massive LSB galaxies, with a total HI mass $\ge$ 10$^{10}$ M$_{sol}$, for H$_0$ = 70 km/s/Mpc. If we expand the definition to also include galaxies with significant total (rather than just gas) mass, i.e., those with inclination-corrected HI line width W$_{50}$,cor > 500 km/s, this bring the total number of massive LSB galaxies to 41. There are no obvious trends between the various measured global galaxy properties, particularly between mean surface brightness and galaxy mass.
description: 71 pages, including all tables and figures; Accepted by AJ
Supersymmetric approach to heavy fermion systems
Creators: name: Ramires, Aline
name: Coleman, Piers
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We propose a generalization of the supersymmetric representation of spins with symplectic symmetry, generalizing the rotation group of the spin from SU(2) to SP(N). As a test application of this new representation, we consider two toy models involving a competition of the Kondo effect and antiferromagnetism: a two-impurity model and a frustrated three-impurity model. Exploring an ensemble of L-shaped representations with a fixed number of boxes in their respective Young tableaux, we allow the system to choose which representation is energetically more favorable in each region in parameter space. We discuss how the features of these preliminary applications can generalize to Kondo lattice models.
description: 22 pages, 10 figures
SoK: Security of Microservice Applications: A Practitioners' Perspective on Challenges and Best Practices
Creators: name: Billawa, Priyanka
name: Tukaram, Anusha Bambhore
name: Ferreyra, Nicolás E. Díaz
name: Steghöfer, Jan-Philipp
name: Scandariato, Riccardo
name: Simhandl, Georg
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.4.6

description: Cloud-based application deployment is becoming increasingly popular among businesses, thanks to the emergence of microservices. However, securing such architectures is a challenging task since traditional security concepts cannot be directly applied to microservice architectures due to their distributed nature. The situation is exacerbated by the scattered nature of guidelines and best practices advocated by practitioners and organizations in this field. This research paper we aim to shay light over the current microservice security discussions hidden within Grey Literature (GL) sources. Particularly, we identify the challenges that arise when securing microservice architectures, as well as solutions recommended by practitioners to address these issues. For this, we conducted a systematic GL study on the challenges and best practices of microservice security present in the Internet with the goal of capturing relevant discussions in blogs, white papers, and standards. We collected 312 GL sources from which 57 were rigorously classified and analyzed. This analysis on the one hand validated past academic literature studies in the area of microservice security, but it also identified improvements to existing methodologies pointing towards future research directions.
description: Accepted at the 17th International Conference on Availability, Reliability and Security (ARES 2022)
Theory for Ligand Rebinding at Cell Membrane Surfaces
Creators: name: Thompson, Nancy L.
name: Lagerholm, B. Christoffer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Conditions for which a ligand reversibly bound to a cell surface dissociates and then rebinds to the surface have been theoretically examined. The coupled differential equations that describe reaction at the interface between sites on a plane and three-dimensional solution have been described previously (Thompson, N. L., T. P. Burghardt, and D. Axelrod. 1981. Biophys. J. 33:435-454). Here, we use this theoretical formalism to provide an analytical solution for the spatial and temporal dependence of the probabilities of finding a molecule on the surface or in the solution, given initial placement on the surface at the origin. This general analytical solution is used to derive a simple expression for the probability that a molecule rebinds to the surface at a given position and time after release at the origin and time zero. The probability expressions provide fundamental equations that form a basis for subsequent modeling of ligand-receptor interactions in specific geometries.
(101501) Richard Collacot
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Methods and Results for Quantum Optimal Pulse Control on Superconducting Qubit Systems
Creators: name: Matekole, Elisha Siddiqui
name: Fang, Yao-Lung L.
name: Lin, Meifeng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The effective use of current Noisy Intermediate-Scale Quantum (NISQ) devices is often limited by the noise which is caused by interaction with the environment and affects the fidelity of quantum gates. In transmon qubit systems, the quantum gate fidelity can be improved by applying control pulses that can minimize the effects of the environmental noise. In this work, we employ physics-guided quantum optimal control strategies to design optimal pulses driving quantum gates on superconducting qubit systems. We test our results by conducting experiments on the IBM Q hardware using their OpenPulse API. We compare the performance of our pulse-optimized quantum gates against the default quantum gates and show that the optimized pulses improve the fidelity of the quantum gates, in particular the single-qubit gates. We discuss the challenges we encountered in our work and point to possible future improvements.
description: updated to the accepted version