cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Workplace information literacy: cultivation strategies for 'working smarter' in 21st century libraries
Creators: name: Somerville, Mary M.
name: Howard, Zaana
name: Mirijamdotter, Anita
Publisher: name: Swinburne
Year: 2024

description: This paper presents a hybrid framework of Swedish cultural practices and Australian grounded theory for organizational development and suggests practical strategies for 'working smarter' in 21st Century libraries. Toward that end, reflective evidence-based practices are offered to incrementally build organizational capacity for asking good questions, selecting authoritative sources, evaluating multiple perspectives, organizing emerging insights, and communicating them to inform, educate, and influence. In addition, to ensure the robust information exchange necessary to collective workplace learning, leadership traits are proposed for ensuring inclusive communication, decision making, and planning processes. These findings emerge from action research projects conducted from 2003 to 2008 in two North American libraries.
Continual reinforcement learning with memory at multiple timescales
Creators: name: Kaplanis, Christos
Publisher: name: Imperial College London
Year: 2020

description: In the past decade, with increased availability of computational resources and several improvements in training techniques, artificial neural networks (ANNs) have been rediscovered as a powerful class of machine learning methods, featuring in several groundbreaking applications of artificial intelligence. Most of these successes have been achieved in stationary, confined domains, such as a game playing and image recognition, but, ultimately, we want to apply artificial intelligence to problems that require it to interact with the real world, which is both vast and nonstationary. Unfortunately, ANNs have long been known to suffer from the phenomenon of catastrophic forgetting, whereby, in a setting where the data distribution is changing over time, new learning can lead to an abrupt erasure of previously acquired knowledge. The resurgence of ANNs has led to an increased urgency to solve this problem and endow them with the capacity for continual learning, which refers to the ability to build on their knowledge over time in environments that are constantly evolving. The most common setting for evaluating continual learning approaches to date has been in the context of training on a number of distinct tasks in sequence, and as a result many of them use the knowledge of task boundaries to consolidate knowledge during training. In the real world, however, the changes to the distribution may occur more gradually and at times that are not known in advance. The goal of this thesis has been to develop continual learning approaches that can cope with both discrete and continuous changes to the data distribution, without any prior knowledge of the nature or timescale of the changes. I present three new methods, all of which involve learning at multiple timescales, and evaluate them in the context of deep reinforcement learning, a paradigm that combines reinforcement learning with neural networks, which provides a natural testbed for continual learning as (i) it involves interacting with an environment, and (ii) it can feature non-stationarity at unpredictable timescales during training of a single task. The first method is inspired by the process of synaptic consolidation in the brain and involves multi-timescale memory at the level of the parameters of the network; the second extends the first by directly consolidating the agent's policy over time, rather than its individual parameters; finally, the third approach extends the experience replay database, which typically maintains a buffer of the agent's most recent experiences in order to decorrelate them during training, by enabling it to store data over multiple timescales.
On the estimation and control of packet loss for VPN services
Creators: name: Lambiri, Cristian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Electronics and Electrical.

description: Virtual Private Services (VPN) are an important service offering for any service provider. It can be justified that in a metro environment some networks will carry only such traffic. In addition, metro networks are characterized by small link spans, which make the propagation delays negligible. In this environment, this dissertation proposes and investigates a service aware network control platform for packet switched networks that is technology agnostic. The basic premises of our work are that VPN are provider based, have well defined QoS behavior specified by the long term loss, and have a degree of user-controllability. The dissertation proposes a number of aggregate traffic loss estimators, based on the theory of large deviations. Our assumptions are that the buffers at each multiplexor are finite, and therefore the loss ratios are computed. It has been noted that large deviations based estimators can be estimated in two main ways: (1) assuming a traffic model and by computing the loss using that model (2) estimating the moment generating function directly. The work compares, through a large number of simulations, the performance of the proposed estimators in both cases. The results show that under the Gaussian model the model-based estimation is very accurate. This conclusion is important because the model-based estimator has better computational complexity when compared with the modeless estimator. Therefore, it is better to be used in practice. The dissertation proposes a new method for atomically admitting VPN service instances in the network. Dubbed Service Admission Control, this generalizes the classical admission control methods by using an atomic operation over a set of class of service instances. Furthermore, we propose and investigate a method for dynamic loss control that is of use when the traffic injected in the network has long timescale changes.
Supplementary document for An Optical Matter Machine: Angular Momentum Conversion by Collective Modes in Optically Bound Nanoparticle Arrays - 4743484.pdf
Creators: name: Parker, John
name: Peterson, Curtis
name: Yifat, Yuval
name: Rice, Stuart
name: Yan, Zijie
name: Gray, Stephen
name: Scherer, Norbert
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Classical and Physical Optics
Optical Properties of Materials

description: Supplemental Material
Clinical presentation and incidence of anaerobic bacteria in surgically treated biliary tract infections and cholecystitis
Creators: name: Strohäker, Jens
name: Wiegand, Lisa
name: Beltzer, Christian
name: Königsrainer, Alfred
name: Ladurner, Ruth
name: Meier, Anke
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: anaerobic infection
subject: cholecystitis
subject: cholangitis
subject: biliary tract infection
subject: DDC 610 / Medicine & health
subject: Cholecystitis
subject: Cholangitis
subject: Gallenblasenentzündung
subject: Cholangitis

description: (1) Background: Cholecystitis and cholangitis are among the most common diseases treated by general surgery. Gallstones lead to inflammation and bacterial infection of the biliary tract. Biliary infections can lead to live threatening bacteremia and liver abscesses. The true role of anaerobes remains unclear. (2) Methods: We retrospectively analyzed bacterial cultures from biliary samples obtained from bile ducts and gallbladders at our tertiary care center. Patient characteristics and clinical outcomes were analyzed. (3) Results: In our database of 1719 patients, 365 patients had microbial testing, of which 42 grew anaerobic bacteria. Anaerobes were more frequently cultured in patients with hepatic abscesses and gallbladder perforation. These patients were older and had more comorbidities than the control group. The overall outcomes of all patients were favorable and the resistance rate to commonly used antibiotics remained low. (4) Conclusions: Anaerobes in biliary tract infections appear to be underdiagnosed and more prevalent in the elderly with advanced disease. Due to low antibiotic resistance, the combination of source control and adjunct anti-infective treatment leads to favorable outcomes.
Coping with criticism and embracing change—further reflexions on the debate on a mental health care system without coercion
Creators: name: Von Peter, Sebastian
name: Zinkler, Martin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: DDC 150 / Psychology
subject: Human rights
subject: Psychiatry
subject: Coercion
subject: Psychiatrie
subject: Zwang
subject: Menschenrecht

description: In August 2019, a manuscript was published in this journal that aimed at imagining a mental health care system that renounces the judicial control to better focus on the will and preferences of those who require support. Alternative scenarios for dealing with risk, inpatient care, and police custody were presented that elicited strong and emotionally laden reactions. This article adds further reflections to this debate, aiming at contributing explanations for this unsettlement. A productive notion of criticism is discussed, and ways to achieve change toward a more human rights-oriented psychiatric practice are outlined.
The entrepreneurial conglomerate: a case study of serial entrepreneurship in a single firm
Creators: name: Arelette, David
Publisher: name: Swinburne
Year: 2024

description: Rather than the traditional study of the serial entrepreneur who starts sequential ventures with their second and other ventures as the previous one matures or is sold, this paper presents a case study of a series of entrepreneurial ventures that have been started from discovered opportunities arising from the progressing initial venture. Through the use of shared resources and the learning accrued from earlier ventures, the firm created six discrete entrepreneurial firms within the parent firm. This paper builds on earlier papers presented at the 1st and 2nd Research Exchanges. A comparative model for entrepreneurial expansion decision making with a firm is proposed that is compared to the Cambridge Technopole cases.
Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms
Creators: name: Van't Hof, Femke N. G.
name: Ruigrok, Ynte M.
name: Lee, Cue Hyunkyu
name: Ripke, Stephan [U.V.M.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: abdominal aortic aneurysm
subject: genome wide association study
subject: intracranial aneurysm
subject: thoracic aortic aneurysm
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co‐occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. Methods and Results We performed a mega‐analysis of 1000 Genomes Project‐imputed genome‐wide association study (GWAS) data of 4 previously published aneurysm cohorts: 2 IA cohorts (in total 1516 cases, 4305 controls), 1 AAA cohort (818 cases, 3004 controls), and 1 TAA cohort (760 cases, 2212 controls), and observed associations of 4 known IA, AAA, and/or TAA risk loci (9p21, 18q11, 15q21, and 2q33) with consistent effect directions in all 4 cohorts. We calculated polygenic scores based on IA‐, AAA‐, and TAA‐associated SNPs and tested these scores for association to case‐control status in the other aneurysm cohorts; this revealed no shared polygenic effects. Similarly, linkage disequilibrium–score regression analyses did not show significant correlations between any pair of aneurysm subtypes. Last, we evaluated the evidence for 14 previously published aneurysm risk single‐nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]=1.11; P=4.1×10−5) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P=1.1×10−3). Conclusions Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication
title: Existenzgründung
title: Freiberufliche Selbständigkeit für Restauratoren
titleType: Subtitle
Creators: name: König-Weska, Romy
Publisher: name: HAWK Hildesheim/Holzminden/Göttingen
Year: 2011
Subjects: Business management

description: Besprochen werden die Gründungplanung, Gründungsarten, Förderprogramme und Finanzierungen, steuerliche Rahmenbedingungen und Versicherungen. Weiterhin wird näher auf die Aufträge, mit Ausschreibungen, dem Kostenvoranschlag, der Auftragserteilung und den Arbeitsverträgen, sowie die Zahlung der Kunden eingegangen.
Optimization of a MIMO radar antenna system for automotive applications
Creators: name: Vasanelli, Claudia
name: Batra, Rahul
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: MIMO radar
subject: Millimeter-wave antennas
subject: DDC 620 / Engineering & allied operations
subject: Radar
subject: Millimeter wave communication systems
subject: MIMO systems
subject: Antenna arrays
subject: MIMO
subject: Radar
subject: Antennengruppe

description: Multiple-Input Multiple-Output (MIMO) radars can improve the angular resolution of automotive radar sensors. In MIMO radars, a critical design parameter is finding the optimal placement of the transmitting and receiving arrays. Indeed, the physical position of the transceivers affects directly the properties of the virtual array. Unfortunately, the inverse mapping from the virtual array to the real transmitter-receiver configuration is still analytically unsolved. In this paper, a genetic algorithm is employed to search the optimal antenna placement. The fitness function exploits the characteristics of the ambiguity function and this allows potentially to control the ambiguity-free region of the antenna system. Numerical and experimental results confirm the suitability of this design procedure.
Isolation and characterisation of human gingival margin-derived STRO-1/MACS+ and MACS− cell populations
Creators: name: El-Sayed, Karim M Fawzy
name: Paris, Sebastian
name: Graetz, Christian
name: Kassem, Neemat
name: Mekhemar, Mohamed
name: Ungefroren, Hendrick
name: Fändrich, Fred
name: Dörfer, Christof
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: alkaline phosphatase
subject: collagen
subject: differentiation
subject: gingiva
subject: osteonectin
subject: osteopontin
subject: polymerase chain reaction
subject: stem cells
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Recently, gingival margin-derived stem/progenitor cells isolated via STRO-1/magnetic activated cell sorting (MACS) showed remarkable periodontal regenerative potential in vivo. As a second-stage investigation, the present study's aim was to perform in vitro characterisation and comparison of the stem/progenitor cell characteristics of sorted STRO-1-positive (MACS+) and STRO-1-negative (MACS−) cell populations from the human free gingival margin. Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies. Subsequently, the MACS+ and MACS− cell fractions were characterized by flow cytometry for expression of CD14, CD34, CD45, CD73, CD90, CD105, CD146/MUC18 and STRO-1. Colony-forming unit (CFU) and multilineage differentiation potential were assayed for both cell fractions. Mineralisation marker expression was examined using real-time polymerase chain reaction (PCR). MACS+ and MACS− cell fractions showed plastic adherence. MACS+ cells, in contrast to MACS− cells, showed all of the predefined mesenchymal stem/progenitor cell characteristics and a significantly higher number of CFUs (P<0.01). More than 95% of MACS+ cells expressed CD105, CD90 and CD73; lacked the haematopoietic markers CD45, CD34 and CD14, and expressed STRO-1 and CD146/MUC18. MACS− cells showed a different surface marker expression profile, with almost no expression of CD14 or STRO-1, and more than 95% of these cells expressed CD73, CD90 and CD146/MUC18, as well as the haematopoietic markers CD34 and CD45 and CD105. MACS+ cells could be differentiated along osteoblastic, adipocytic and chondroblastic lineages. In contrast, MACS− cells demonstrated slight osteogenic potential. Unstimulated MACS+ cells showed significantly higher expression of collagen I (P<0.05) and collagen III (P<0.01), whereas MACS− cells demonstrated higher expression of osteonectin (P<0.05; Mann–Whitney). The present study is the first to compare gingival MACS+ and MACS− cell populations demonstrating that MACS+ cells, in contrast to MACS− cells, harbour stem/progenitor cell characteristics. This study also validates the effectiveness of the STRO-1/MACS+ technique for the isolation of gingival stem/progenitor cells. Human free gingival margin-derived STRO-1/MACS+ cells are a unique renewable source of multipotent stem/progenitor cells.
Meeting connectivity requirements in a wireless multihop network
Creators: name: Li, Jianxin
name: Andrew, Lachlan L. H.
name: Foh, Chuan Heng
name: Zukerman, Moshe
name: Neuts, Marcel F.
Publisher: name: Swinburne
Year: 2024

description: This paper investigates the connectivity probability of 1-dimensional ad hoc networks in which nodes have random, non-identically distributed locations, this leads to optimization of the number of nodes required. An empirical approach is used. We fit a parametric distribution to the CDF of the maximum distance between adjacent nodes. Special and extreme cases which are not covered by the empirical approach are treated separately.
Taxonomy, systematics and DNA barcoding of selected Penicillium groups
Creators: name: Rivera, Karol Geraldina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Systematic.

description: Cytochrome c oxidase subunit 1 (Cox 1) is the barcode for many animal groups, protists, and macroalgae. Previously in fungi, the efficiency of Cox 1 as a genetic marker was only analysed in Penicillium subgenus Penicillium and Leohumicola spp. In this thesis, two species isolated from the intestinal tracts of caterpillars from Costa Rica, and two potential species complexes, P. sclerotiorum and P. oxalicum belonging to Penicillium subgenus Aspergilloides and Furcatum, were studied using the Genealogical Concordance Concept (Gee) recognition criterion and barcoding methods. Analyses with beta-tubulin (BenA), the nuclear internal transcriber spacer (ITS) region, Cox 1, translation elongation factor 1-alpha (TEF1-alpha), and calmodulin (CaM) revealed that the Penicillium species isolated from Costa Rica are undescribed, and that P. sclerotiorum is a complex of seven phylogenetic species (including the Costa Rican species) that fit the prevailing morphological concept of P. sclerotiorum. The phylogenetic species were compared and newly discovered diagnostic morphological characters were used to create a taxonomic key to the species of the complex. The new species are formally described as P. guanacastense, P. mallochii, P. krugii, P. cainii, P. jacksonii and P. ciebiessum. Analyses of multiple strains of P. oxalicum revealed that it is a single phylogenetic species, despite having a world wide distribution, an unusually high degree of morphological variation, and a diversity of ecological roles. Cox1 proved to be a good barcode for identifying the selected Penicillium groups, and provided a species level resolution of 83.3%. ITS provided the same resolving ability. BenA (91.7%), TEF1-alpha (100%) and CaM (100%) provided a higher species level resolution than Cox1, but BenA, TEF1-alpha, and CaM were difficult to amplify or sequence for some Penicillium groups. A secondary barcode marker is suggested in addition to Cox1 for Penicillium.
Supplementary document for Moxifloxacin based axially swept wide-field fluorescence microscopy for high-speed imaging of conjunctival goblet cells - 4743955.pdf
Creators: name: Lee, Jungbin
name: Kim, Seonghan
name: Yoon, Chang Ho
name: Kim, Myoung Joon
name: Kim, Ki Hean
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Moxifloxacin based axially swept wide-field fluorescence microscopy (MBAS-WFFM) and two-photon microscopy (TPM) images of the normal mouse conjunctiva, ex vivo.
An exploration of the epidemiology, quality and methods of systematic reviews of health professional behaviour change interventions
Creators: name: Weir, Michelle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Epidemiology.

description: This thesis describes the epidemiology, quality and methods of systematic reviews of health professional behaviour change interventions. The epidemiology was explored using descriptive methods and the quality was assessed with the AMSTAR tool. 'Lumping' and 'splitting', which refers to how broad or narrow a systematic review question is framed, was explored by assessing a subset of reviews to see how review authors framed their systematic review question and justified this decision. The results indicate that there has been an increase in the number of systematic reviews published on professional behaviour change interventions, they are dispersed across various literature sources and the reviews were generally of poor quality. Furthermore, many reviews are 'split', with little justification for the authors' choice of research question. The overlapping subject areas in addition to the low methodological quality raise concern about the organization of the field, including redundancy of publications and potential duplication of efforts.
Global citizenship, the Internet and the Olympics: The Free Tibet cause
Creators: name: Hiles, Adrienne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Mass Communications.

description: The nature of citizenship has evolved considerably since ancient times. No longer content to leave participation to the few, new modes of political discourse are taking place through the use of Internet forums. Using a combination of critical discourse analysis and content analysis to examine the postings to the "Issues and Causes" forum on the Phayul.com Tibetan news site during the two-week period leading up to the 2008 Beijing Olympics, this thesis investigates how global citizen identity manifests itself online when the cause is state-building. Three key findings emerge from the study. First, the themes and values of global citizenship are present only to a very limited degree. Second, the users employed pronouns to discursively connect themselves to the Tibetan community, and disconnect themselves from outsiders. Third, the forum displayed a significant amount of "flaming" or disruptive discourse. Taken together these results suggest that in this case much of global citizenship theory does not appear to stand up to empirical scrutiny.
Richtungswechsel: die neue Klimapolitik der Obama-Administration
Creators: name: Lemke, Christiane
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 320 / Political science
subject: Sustainable development
subject: Klimaschutz
subject: Online-Publikation
subject: Ringvorlesung
subject: USA

description: Mit dem Regierungswechsel in Washington hat die amerikanische Regierung einen Richtungswechsel in der Klimapolitik eingeleitet. Seit Mai 2009 nehmen die USA wieder aktiv an den Verhandlungen zum internationalen Klimaschutzabkommen teil. Bereits Ende 2009 sollen in Kopenhagen die Verhandlungen über ein Nachfolgeabkommen des 2010 ablaufenden Kyoto-Protokolls stattfinden, an denen sich die USA aktiv beteiligen werden. Die Vorlesung soll die US-amerikanischen Konzepte im Widerstreit zwischen globalen Klimaschutzzielen und wirtschaftlichen Interessen sowie den Einfluss der innenpolitischen Machtverhältnisse vor dem Hintergrund der internationalen Verhandlungen behandeln. Welche innenpolitischen Weichenstellungen hat die Obama-Administration bereits eingeleitet? Wie positionieren sich die USA in den internationalen Verhandlungen? Gibt eine tragfähige Basis für gemeinsame Ziele und internationale Normsetzungen? Kann sich das Prinzip der Nachhaltigkeit durchsetzen?
title: Early administration of levosimendan is associated with improved kidney function after cardiac surgery
title: a retrospective analysis
titleType: Subtitle
Creators: name: Balzer, Felix
name: Treskatsch, Sascha
name: Spies, Claudia
name: Sander, Michael
name: Kastrup, Mark
name: Grubitzsch, Herko
name: Wernecke, Klaus-Dieter
name: Braun, Jan P.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Several animal studies suggest beneficial effects on kidney function upon administration of levosimendan. As recent data from clinical studies are heterogeneous, we sought to investigate whether levosimendan is associated with improved postoperative kidney function in cardiac surgery patients with respect to timing of its administration. Methods Retrospective, single centre, observational analysis at a university hospital in Berlin, Germany. All adult patients without preoperative renal dysfunction that underwent coronary artery bypass grafting and/or valve reconstruction/replacement between 01/01/2007 and 31/12/2011 were considered for analyses. Results Out of 1.095 included patients, 46 patients were treated with levosimendan due to a severely reduced left ventricular systolic function preoperatively (LVEF
Effect of mechanical insert on the behaviour of pultruded fibre reinforced polymer (FRP) bolted joint
Creators: name: Hizam, R. M.
name: Karunasena, Warna
name: Manalo, Allan C.
Publisher: name: Swinburne
Year: 2024

description: The performance of joints has been regarded as the main factor that limits the growth of pultruded fibre reinforced polymer in civil engineering applications. This paper investigates the effect of mechanical insert on the joint strength and failure mechanism of pultruded glass FRP (GFRP). Three (3) types of specimens were used namely joint without mechanical insert, joint with mechanical insert but without adhesive and joint with mechanical insert and adhesive. This corresponds to the specimens N, I and G, respectively. A total of fifteen specimens were tested up to failure in ambient temperature. The experimental results showed that the presence of mechanical insert has improved the joint strength by 24% and the joint stiffness by 26% of pultruded GFRP bolted joint. Meanwhile, adhesively bonded mechanical insert used in specimen G is capable to contribute almost 92% improvement of joint strength. Most of the test specimens failed in shear-out mode. Specimens I and G exhibited brittle-type failures after the maximum load. This preliminary study shows good performance of mechanical insert in improving the bolted joint connection of square hollow section (SHS) pultruded GFRP profile.
L'évolution biologique et psychique selon Charles Darwin et Pierre Teilhard de Chardin.
Creators: name: Carrière, Marie-Rose.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Biology, General.

description: C'est a travers la science et par la science que l'Homme a pris conscience de son Evolution. L'Homme s'en est ensuite convaincu. La science demontre, en plus, que l'Evolution elle-meme est soutenue par un courant evolutif special qui se poursuit a travers la duree et l'espace. Elle est, cette Evolution, flexible, souple et tenace. Elle poursuit toujours son chemin et par En-Avant et par En-Haut. Rien ne peut l'en empecher. Elle continuera d'evoluer jusqu'au temps ou elle atteindra son point omega. L'Homme actuel peut couper le fil de l'Evolution bio-terrestre et meme rater le plus-etre de son Evolution. Mais pas celui de l'Evolution generale c'est-a-dire de l'Univers, car l'Evolution reussira malgre ces contre-coups. Ne nous attardons pas dans les dedales evolutifs. Qui nous dit que, seule, notre planete--Terre--soit un domaine d'intelligence? Attendons les nouvelles explorations ou les nouveaux signaux d'etres extra-terrestres$\sp1$! ftn$\sp1$cf. Teilhard de Chardin, Comment Je Crois, tome 10, "Une suite aux Problemes des Origines humaines: La Multiplicite des Mondes habites", 1953, p. 273.
Fatal neurotoxicosis in dogs associated with tychoplanktic, anatoxin-a producing tychonema sp. in mesotrophic Lake Tegel, Berlin
Creators: name: Beulker, Camilla
name: Chorus, Ingrid
name: Fastner, Jutta
Publisher: name: My University
Year: 2018
Subjects: Blaualgen
Makrophyten

description: In May 2017, at least 12 dogs showed signs of acute neurotoxicosis after swimming in or drinking from Lake Tegel, a mesotrophic lake in Berlin, Germany, and several of the affected dogs died shortly afterwards despite intensive veterinary treatment. Cyanobacterial blooms were not visible at the water surface or the shorelines. However, detached and floating water moss (Fontinalis antipyretica) with high amounts of Tychonema sp., a potential anatoxin-a (ATX) producing cyanobacterium, was found near the beaches where the dogs had been swimming and playing. Necropsies of two of the dogs revealed no specific lesions beside the anamnestic neurotoxicosis. ATX was detected in concentrations up to 8700 Ìg Lâ Ì1 in the stomach contents, while other (neuro)toxic substances were not found. In the aqueous fraction of Fontinalis/Tychonema clumps sampled after the casualties, ATX was found in concentrations up to 1870 Ìg Lâ Ì1. This is the first report of a dense population of Tychonema sp. in stands of Fontinalis resulting in high ATX contents. This case emphasizes the need for further investigation of potentially toxic, non-bloom forming cyanobacteria in less eutrophic water bodies and underlines the novel challenge of developing appropriate surveillance schemes for respective bathing sites. Quelle: https://www.mdpi.com
HIPASS detection of an intergalactic gas cloud in the NGC 2442 group
Creators: name: Ryder, S. D.
name: Koribalski, B.
name: Staveley-Smith, L.
name: Kilborn, Virginia
name: Malin, D. F.
name: Banks, G. D.
name: Barnes, D. G.
name: Bhatal, R.
name: De Blok, W. J.G.
name: Boyce, P. J.
name: Disney, M. J.
name: Drinkwater, M. J.
name: Ekers, R. D.
name: Freeman, K. C.
name: Gibson, B. K.
name: Henning, P. A.
name: Jerjen, H.
name: Knezek, P. M.
name: Marquarding, M.
name: Minchin, R. F.
name: Mould, Jeremy
name: Oosterloo, T.
name: Price, R. M.
name: Putman, M. E.
name: Sadler, E. M.
name: Stewart, I.
name: Stootman, F.
name: Webster, R. L.
name: Wright, A. E.
Publisher: name: Swinburne
Year: 2024

description: We report the discovery from the H I Parkes All-Sky Survey (HIPASS) of a gas cloud associated with the asymmetric spiral galaxy NGC 2442. This object, designated HIPASS J0731-69, contains ~109 Msolar of H I, or nearly one-third as much atomic gas as NGC 2442 itself. No optical counterpart to any part of HIPASS J0731-69 has yet been identified, consistent with the gas being diffuse and its streamlike kinematics. If the gas in HIPASS J0731-69 was once part of NGC 2442, then it was most likely a fairly recent tidal encounter with a moderately massive companion that tore it loose, although the possibility of ram-pressure stripping cannot be ruled out. This discovery highlights the potential of the HIPASS data for yielding new clues to the nature of some of the best-known galaxies in the local universe.
Experimental study on the behavior of GFRP-to-steel bolted joints
Creators: name: Zhan, Y.
name: Wu, G.
Publisher: name: Swinburne
Year: 2024

description: Experimental research has been conducted to study the behavior of a new type of GFRP-to-steel bolted joint. Two types of GFRP-to-steel bolted joints were investigated in this paper including ordinary GFRP-to-steel bolted joint (specimen JO) which only use bolts and washers and stiffer GFRP-to-steel bolted joint (specimen JS) reinforced with epoxy and steel cover plates. The observed failure modes of the two types of connections were always the failure of the pultruded GFRP profiles. The data of applied load and displacement of representative specimens were obtained during the tests. Test results indicated that specimen JS exhibited an increase of 422% in the mean initial stiffness, 61.9% in the average joint strength and 12.6% in the mean joint efficiency, respectively, over specimen JO, therefore it can be stated that the behavior of specimen JS is superior to the performance of specimen JO. Meanwhile, it is also found that the performance of the interface between GFRP shape and cover plates is one of the key factors that affects the behavior of specimen JS due to the fact that the ultimate failure took place as soon as debonding occurred between GFRP element and cover plates. Furthermore, the influence of the slip factor on the slip load was also studied.
Supplementary document for Moxifloxacin based axially swept wide-field fluorescence microscopy for high-speed imaging of conjunctival goblet cells - 4743955.pdf
Creators: name: Lee, Jungbin
name: Kim, Seonghan
name: Yoon, Chang Ho
name: Kim, Myoung Joon
name: Kim, Ki Hean
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Moxifloxacin based axially swept wide-field fluorescence microscopy (MBAS-WFFM) and two-photon microscopy (TPM) images of the normal mouse conjunctiva, ex vivo.
A study on the effect of casting and curing temperature on the mechanical properties of concrete.
Creators: name: Sau, Pak-Lok.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1984
Subjects: subject: Engineering, Civil.

description: Conventional winter concreting practice in Canada recommends concrete to be mixed and placed at 10°C or above and be cured for seven days (not necessarily consecutive) at which the air temperature is above 10°C. However, construction of offshore Arctic structures will usually take place at temperatures close to that of the sea at approximately 0 to 4°C; and hence information on the influence of temperature during mixing, placing and curing on the development of concrete strength is essential. Previous research has shown conflicting results on the effect of casting and curing temperature. Since the economic benefits of being able to place and cure concrete at low temperature without any strength penalty are significant, this study was undertaken to examine the effect of casting and curing temperature on the mechanical properties of concrete. Standard concrete cylinders made of type 10 Portland cement were cured extensively at 0°C, 16°C and 43°C after holding the specimens at various casting temperatures for 3 to 12 hours to separate the effect of casting temperature and curing temperature. Concrete prisms were also cast and cured at 0°C, 16°C and 45°C to determine dynamic modus of elasticity. The tests an compressive strength, indirect tensile strength, static and dynamic modulus of elasticity were carried out at the ages of 3, 7, 14, 26 and 90 days. In general, the compressive strength increased with increasing time and decreasing water-cement ratio. The lower the water-cement ratio, the faster the concrete gained its strength. The effect of temperature on the strength development was found to be depended upon the water-cement ratio of the concrete. The study showed that casting and curing at 0°C or 45°C would not damage the concrete strength but conversely increased the strength if the water-cement ratio was kept below 0.35. Concrete cast and cured several hours at 0°C or 45°C and subsequently cured at 16°C received no damage but benefits to its strength providing water-cement ratio was as low as 0.45. However, extreme casting or curing temperature should be discouraged for water-cement ratio above 0.55. Tensile strength, static and dynamic modulus of elasticity increased with increasing compressive strength but at a different rates depending on the casting and curing temperature. Tensile strength, static and dynamic modulus of elasticity were related to the power of 0.60, 0.65 and 0.31 of the cylinder strength, respectively.
Virotherapy in Germany : recent activities in virus engineering, preclinical development, and clinical studies
Creators: name: Nettelbeck, Dirk M.
name: Leber, Mathias F.
name: Altomonte, Jennifer
name: Angelova, Assia
name: Beil, Julia
name: Berchtold, Susanne
name: Delic, Maike
name: Eberle, Jürgen
name: Ehrhardt, Anja
name: Engeland, Christine E.
name: Fechner, Henry
name: Geletneky, Karsten
name: Goepfert, Katrin
name: Holm, Per Sonne
name: Kochanek, Stefan
name: Kreppel, Florian
name: Krutzke, Lea
name: Kühnel, Florian
name: Lang, Karl Sebastian
name: Marchini, Antonio
name: Moehler, Markus
name: Mühlebach, Michael D.
name: Naumann, Ulrike
name: Nawroth, Roman
name: Nüesch, Jürg
name: Rommelaere, Jean
name: Lauer, Ulrich M.
name: Ungerechts, Guy
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: virotherapy
subject: research in Germany
subject: virus engineering
subject: virus targeting
subject: therapeutic transgene
subject: combination therapy
subject: DDC 570 / Life sciences
subject: Clinical trials
subject: Oncolytic Viruses
subject: Immunotherapy
subject: Immuntherapie
subject: Kombinationstherapie
subject: Klinisches Experiment

description: Virotherapy research involves the development, exploration, and application of oncolytic viruses that combine direct killing of cancer cells by viral infection, replication, and spread (oncolysis) with indirect killing by induction of anti-tumor immune responses. Oncolytic viruses can also be engineered to genetically deliver therapeutic proteins for direct or indirect cancer cell killing. In this review—as part of the special edition on “State-of-the-Art Viral Vector Gene Therapy in Germany”—the German community of virotherapists provides an overview of their recent research activities that cover endeavors from screening and engineering viruses as oncolytic cancer therapeutics to their clinical translation in investigator-initiated and sponsored multi-center trials. Preclinical research explores multiple viral platforms, including new isolates, serotypes, or fitness mutants, and pursues unique approaches to engineer them towards increased safety, shielded or targeted delivery, selective or enhanced replication, improved immune activation, delivery of therapeutic proteins or RNA, and redirecting antiviral immunity for cancer cell killing. Moreover, several oncolytic virus-based combination therapies are under investigation. Clinical trials in Germany explore the safety and potency of virotherapeutics based on parvo-, vaccinia, herpes, measles, reo-, adeno-, vesicular stomatitis, and coxsackie viruses, including viruses encoding therapeutic proteins or combinations with immune checkpoint inhibitors. These research advances represent exciting vantage points for future endeavors of the German virotherapy community collectively aimed at the implementation of effective virotherapeutics in clinical oncology.
Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model
Creators: name: Atkinson, Sara Marie
name: Bleil, Janine
name: Maier, René
name: Kühl, Anja A.
name: Thorn, Mette
name: Serikawa, Kyle
name: Fox, Brian
name: Kruse, Kim
name: Haase, Claus
name: Skov, Søren
name: Nansen, Anneline
name: Syrbe, Uta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Arthritis
subject: Joint inflammation
subject: Bone destruction
subject: Bone formation
subject: Osteoclast
subject: RANKL
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destruction, and bone formation. Methods DTHA was induced in C57BL/6 mice. Inflammation, erosive joint damage, and new bone formation were semiquantitatively scored by histology. Osteoclast activity was assessed in vivo, and messenger RNA (mRNA) expression of mediators of bone destruction and bone formation were analyzed by mRNA deep sequencing. Serum concentrations of tartrate-resistant acid phosphatase 5b, carboxy-terminal telopeptide I (CTX-I), matrix metalloproteinase 3 (MMP3), and serum amyloid P component (SAP) were determined by enzyme-linked immunosorbent assay. Anti-RANKL monoclonal antibody treatment was initiated at the time of immunization. Results Bone destruction (MMP3 serum levels, cathepsin B activity, and RANKL mRNA) peaked at day 3 after arthritis induction, followed by a peak in cartilage destruction and bone erosion on day 5 after arthritis induction. Periarticular bone formation was observed from day 10. Induction of new bone formation indicated by enhanced Runx2, collagen X, osteocalcin, MMP2, MMP9, and MMP13 mRNA expression was observed only between days 8 and 11. Anti-RANKL treatment resulted in a modest reduction in paw and ankle swelling and a reduction of serum levels of SAP, MMP3, and CTX-I. Destruction of the subchondral bone was significantly reduced, while no effect on bone formation was seen. Conclusions Anti-RANKL treatment prevents joint destruction but does not prevent new bone formation in the DTHA model. Thus, although occurring sequentially during the course of DTHA, bone destruction and bone formation are apparently not linked in this model.
title: Step-by-step guide to sustainable supply chain management
title: Step-by-step guide to sustainable supply chain management
titleType: AlternativeTitle
title: A Practical Guide for Companies
titleType: AlternativeTitle
Creators: name: Weiss, Daniel
name: Hajduk, Thomas
name: Knopf, Jutta
Publisher: name: My University
Year: 2017
Subjects: subject: Lieferkette
subject: supply chain
subject: sustainable production
subject: Economy | Consumption

description: Ein Großteil der Umweltbelastungen entsteht in der Lieferkette. Daraus ergeben sich hier große Reduktionspotenziale für kleinere und mittelständische Betriebe. Die Broschüre ist insbesondere für mittelständische Unternehmen interessant, die bereits ein solides Fundament an Umwelt- oder Nachhaltigkeitspraktiken in ihren Werkshallen und Büros gelegt haben und nun beim nachhaltigen Lieferkettenmanagement erste Schritte gehen möchten. Für Unternehmen, die bereits ein Umweltmanagementsystem nach EMAS oder ISO 14001 eingeführt haben, bietet der Leitfaden Ansatzpunkte für das Management indirekter Umweltaspekte und die Betrachtung des Lebensweges von Produkten und Dienstleistungen. Quelle: Verlagsinformation
description: Many smaller and medium-sized companies, like larger companies, are already engaging with social responsibility in their business practices. At the same time, they are being asked to live up to their social reponsibilities when it comes to their supply chains and are motivated to do so, as supply chains are the origin of a large share of environmental impacts. Supply chains also hold great potential for and provide opportunities to avoid or at least decrease considerable risks to the environment, those impacted, and the companies themselves. The catastrophic impact of suppliers’ insufficient security and occupational health and safety standards, as the collapse of the Rana Plaza building in Bangladesh revealed, shows how important and urgent it is for companies to address the social impact of their activities within their supply chains as well.
Anchorage systems in concrete structures strengthened with carbon fiber reinforced polymer composites
Creators: name: Kalfat, Robin
Publisher: name: Swinburne
Year: 2024

description: The development of fiber composite materials and their application to structural elements as externally bonded reinforcement is an effective means to increase the strength of existing bridges and buildings. However, the technique is limited by premature debonding of the composite materials from the concrete substrates which typically results in higher material quantities required to reach a given level of strengthening. As a means of addressing this issue, this dissertation examines the use of innovative anchorage systems to improve the bond performance between carbon fibers and structural elements. An efficient bidirectional fiber patch anchor was developed using experimental and numerical techniques, the results of which were applied to the Westgate Bridge Strengthening project.
Using convolutional neural networks for stereological characterization of 3D hetero-aggregates based on synthetic STEM data: FAIR data
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: synthetic HAADF-STEM,
subject: nanoparticle aggregate
subject: hetero-aggregate
subject: DDC 510 / Mathematics
subject: Scanning transmission electron microscopy
subject: Nanoparticles
subject: Raster-Transmissions-Elektronenmikroskopie
subject: Nanopartikel

description: A dataset of Synthetic STEM-image data of various hetero-aggregates is presented. The aggregates consist of TiO2 and WO3 primary particles. The aggregates are generates using a stochastic 3D model which is based on cluster-cluster aggregation. A physic based simulator is used to generate the STEM-images.
SELEN MIKROELEMENTINING GORMONLAR FAOLIYATIDAGI AHAMIYATI
Creators: name: Avadullayeva, M.S.
Publisher: name: Zenodo
Year: 2024

description: Selen mikroelementi inson organizmida zarur bo‘lib, u gormonlar faoliyatini ta'minlash va endokrin tizimning sog‘lom ishlashida muhim rol o‘ynaydi. Selen yetishmovchiligi turli kasalliklar, jumladan, metabolik va gormonal muammolarni keltirib chiqarishi mumkin. Ushbu tezisda selenning gormonlar faoliyatiga ta’siri, gormonlar ishlab chiqarish va muvozanatini saqlashdagi ahamiyati ko‘rib chiqiladi.
Large deviations for rough and complete stochastic volatility models
Creators: name: Lacombe, Chloe Alice
Publisher: name: Imperial College London
Year: 2019

description: Stochastic volatility models are known to capture features observed in the markets and have been widely used in the financial industry. In particular, rough volatility models, where the instantaneous volatility is driven by a fractional Brownian motion, provide a more accurate fit of the power-law decay observed on volatility smiles close to maturity. This thesis is concerned with deriving the asymptotic behaviour of these two classes of stochastic volatility models using large deviations techniques, in order to understand the behaviour of the implied volatility. Indeed, when pricing options, a closed-form solution to the pricing problem is often not available. Practitioners are using implied volatility as a measure of option prices that is consistent for different options with different maturities and strike prices. As this implied volatility cannot be expressed in closed form either, finding asymptotic formulas is crucial. We therefore focus on ob- taining the asymptotic behaviour of two rough volatility models, namely a generalised version of the Stein-Stein model where the volatility starts from a random distribution and the (multi-factor) rough Bergomi model for realised variance options. We also study a particular complete model with stochas- tic volatility, which can be fitted to market data perfectly via the leverage function. In each case, we obtain the asymptotic behaviour of the stock price process and the implied volatility. We produce numerical schemes to compute the implied volatility smiles.