cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Preparative isolation of paclitaxel and related taxanes from cell cultures of Taxus chinensis using reversed-phase flash chromatography
Creators: name: Liang, Zhi-Kun
name: Ruo-Gu Huang
name: Xie, Zhi-Sheng
name: Xu, Xin-Jun
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: In this study, paclitaxel, baccatin III, taxuyunnanine C and sinenxane C were successfully separated by reversed-phase flash chromatography on a manually packed C18 column from Taxus chinensis cell culture extract. The crude cell culture extract was first treated with Al2O3 column chromatography and then divided into two parts: fraction 1 and fraction 2. Ten milligrams of baccatin III and 19 mg of paclitaxel were obtained from 100 mg dried fraction 1. Fifty-two milligrams of taxuyunnanine C and 11 mg sinenxane C were obtained from 100 mg dried fraction 2. The purities of the four compounds were 98.02%, 98.53%, 98.93% and 98.76%, respectively. Their structures were characterised by using UV, MS and NMR. These results indicate that paclitaxel and related taxanes including baccatin III can be obtained from cell culture in a highly pure state using reversed-phase flash chromatography.
Establishment of the National Bioeconomy Hubs
Creators: name: CSCP
Publisher: name: Zenodo
Year: 2023

description: The purpose of this document is, first and foremost, to present documentation and verification of the establishment of ten National Bioeconomy Hubs (‘Hub’) of the CEE2ACT project, one in each of the CEE2ACT target countries. It first provides a definition of the National Bioeconomy Hub and explains the aims of the Hub and their role that they play in the project (chapter 2). In chapter 3, the standardised structure of the online presence of the Hubs is outlined. Chapter 4 gives a brief summary of each Hub’s first workshop in terms of focus and participating stakeholders. The URL to the webpage of each Hub is provided. Observations and next steps for the Hubs is summarised in chapter 5. Finally, the agendas of each Hub workshop can be found in the annex (chapter 6).
Phylogenomic insights into the radiation of an Andean group of plants
Creators: name: Uribe-Convers, Simon
Publisher: name: figshare
Year: 2015
Subjects: subject: Molecular Biology
subject: Botany
subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology
subject: Evolutionary Biology

description: This dissertation focuses on the evolutionary history of the Neobartsia clade of the plant genus Bartsia (Orobanchaceae) distributed throughout the high elevation páramo ecosystem in the Andes. This group of plants was the subject of a detailed taxonomic study in the 1990’s, as well as various phylogenetic studies at higher taxonomic levels. However, the work presented in this dissertation constitutes the most comprehensive study of the group so far. I conducted extensive fieldwork throughout the Andes and was able to sample every species described to date, including multiple individuals per species for many, and I have used these collections to elucidate phylogenetic relationships among closely related genera, and between the ~45 species in the clade. My molecular systematic work was accompanied by comparative phylogenetic studies focused on the time of divergence, historical biogeography, and the rate of diversification of the group, which showed that the clade is the result of an ongoing recent and rapid radiation that began ~3 million years ago – a time period when the northern Andes had the necessary elevation to generate alpine conditions. It was clear from these studies, that the genetic diversity within Neobartsia was low, given the young age of the genus, and therefore, I began to focus on developing genomic approaches to generate large amounts of phylogenetic data, both efficiently and cost effectively. This last part of my dissertation resulted in two genomic methods being developed, one for sequencing complete chloroplast genomes, and one for generating targeted subgenomic datasets, which were used to generate the data necessary to elucidate interspecific relationships. Finally, I revised the taxonomy of the clade and its closely allied genera to reflect these phylogenetic results, alleviating a history of taxonomic instability by elevating the South American Bartsia clade to the newly formed genus Neobartsia, thereby recognizing its unique evolutionary history.
Financial Inclusion Initiatives and their Effects on Socio-Economic Development in India
Creators: name: Dr Ashok Kumar Mishra
Publisher: name: Zenodo
Year: 2016

description: Financial inclusion initiatives play a pivotal role in promoting socio-economic development, particularly in countries like India with significant unbanked populations. This research paper examines the impact of financial inclusion initiatives on socio-economic development in India, focusing on key indicators such as poverty alleviation, income generation, and access to essential services. Through a review of literature and empirical analysis, the paper highlights the positive correlation between financial inclusion and various socio-economic outcomes. The findings underscore the transformative potential of expanding access to formal financial services in empowering marginalized communities and fostering inclusive growth. The paper also discusses policy implications and recommendations for enhancing the effectiveness of financial inclusion initiatives in India.
Baseline assessment report on bioeconomy implementation and policy development in CEE2ACT target countries
Creators: name: BOKU
Publisher: name: Zenodo
Year: 2023

description: This report attempts to provide a clear picture of the current state of play of the development of the implementation of circular bioeconomy and circular bioeconomy strategies in the CEE2ACT countries including Baltic States.On the one hand, extended inventories of the implementation of bioeconomy strategies but also on socio-economic and environmental framework are provided to show the status quo in each country. On the other hand, main challenges and potentials have been queried from target country partners. The information is complemented with existing data and knowledge from reports of BIOEASTsUP and dashboards of the European Commission’s Knowledge Centre of Bioeconomy.
title: Code verification of non‐linear immersed boundary simulations using the method of manufactured solutions
Creators: name: Petö, Márton
name: Juhre, Daniel
name: Eisenträger, Sascha
Publisher: name: Wiley-VCH
Year: 2024

description: Non‐standard finite element technologies, such as immersed boundary approaches, are typically based on novel algorithms and advanced methods, which require reliable testing of the implemented code. For this purpose, the method of manufactured solutions (MoMS) offers a great framework, enabling an easy and straightforward derivation of closed‐form reference solutions. In this contribution, the focus is kept on non‐linear analysis via the finite cell method (FCM), which is typically based on an unfitted geometry discretization and higher‐order shape functions. The code verification via MoMS generally requires the application of boundary conditions to all boundaries of the simulation domain, which need to be enforced in a weak sense on the immersed boundaries. To avoid this, we propose a novel way of deriving manufactured solutions, for which the necessary constraints on the embedded boundaries are directly fulfilled. Thus, weak boundary conditions can be eliminated from the FCM simulation, and the simulation complexity is reduced when testing other relevant features of the immersed code. In particular, we focus on finite strain analysis of 3D structures with a Neo‐Hookean material model, and show that the proposed technique enables a reliable code verification approach for all load steps throughout the deformation process.
Metadata Evaluation and Improvement
Creators: name: Habermann, Ted
Publisher: name: figshare
Year: 2014
Subjects: subject: Palynology
subject: Paleoclimatology
subject: Soil Science
subject: Physical Geography
subject: Atmospheric Sciences
subject: FOS: Earth and related environmental sciences
subject: Hydrology
subject: Mineralogy
subject: Information Systems
subject: FOS: Computer and information sciences
subject: Geophysics
subject: Oceanography
subject: Data Format
subject: Environmental Science
subject: Limnology
subject: Climate Science
subject: Geology
subject: Solid Earth Sciences
subject: Ecology
subject: FOS: Biological sciences

description: As the number of datasets available to scientists and the public increases metadata discussions and systems have focused on discovery of data. This is an important step, but, one data are discoverred, they must be usable and understandable in order to be reused confidently. Methods for evaluating metadata must improve beyond comparisons with lists of fields required for discovery. This paper outlines some ideas for approaches to integrated metadata evaliation and improvement.
Increasing diversity in emerging non-religious communities
Creators: name: Hassall, Christopher
name: Bushfield, Ian
Publisher: name: figshare
Year: 2014
Subjects: subject: Religious Studies
subject: Sociology
subject: FOS: Sociology
subject: Gender studies

description: Contemporary growth in non-religious populations has given rise to novel communities with unique perspectives on social and technological issues. We describe a study of diversity within speakers at conferences organised by and attended by the atheist community. We analyse trends in diversity of 630 speakers, corresponding to 1223 speaking slots at 48 non-religious conferences over the period 2002-2014. Diversity (defined using multivariate statistics) and the representation of women and minority ethnicities increased significantly over time during the period studied. This success in broadening participation may have arisen from the empirical perspective taken on social issues by the non-religious community. However, on-going problems with data collection and the imbalance in the social cost of identifying as non-religious between different social groups remain as barriers to equality within this growing movement.
Post-marketing safety of anti-IL-5 monoclonal antibodies (mAbs): an analysis of the FDA Adverse Event Reporting System (FAERS)
Creators: name: Zou, Shu-Peng
name: Yang, Hai-Yun
name: Ouyang, Mengling
name: Cheng, Qian
name: Shi, Xuan
name: Sun, Ming-Hui
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Anti-IL-5 monoclonal antibodies (mAbs) targeting IL-5 or IL-5 R α (including mepolizumab, benralizumab, and reslizumab) are widely used for inflammatory diseases such as asthma, eosinophilia, and polyangiitis. However, real-world data regarding its safety in a large sample population are incomplete. So, we evaluated the safety of anti-IL-5 mAbs by pharmacovigilance analyzes based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS). In disproportionality analysis, four algorithms were employed to detect the signals of anti-IL-5 mAbs from the FAERS between 2016 and 2022. In addition, we also used MYSQL 8.0, Navicat Premium 15, and Microsoft EXCEL 2019 to analyze the signals of anti-IL-5 mAbs systematically. There are 9,476,351 reports collected from the FAERS database, of which 22,174 reports listed anti-IL-5 mAbs as the ‘primary suspected (PS)’ drug. A total of 59 (20 new signals, mepolizumab) and 62 (19 new signals, benralizumab) significant disproportionality preferred terms (PTs) conforming to the four algorithms were retained synchronously. Finally, we detected that the anti-IL-5 mAbs-induced AEs occurred in 31 organ systems (mepolizumab) and 30 organ systems (benralizumab). For mepolizumab and reslizumab, unexpected and new significant PTs of AEs were found, such as asthmatic crisis, chronic obstructive pulmonary disease (COPD), pneumonia, COVID-19, pneumothorax, adrenal insufficiency and so on. Notably, the risk signal of asthmatic crisis for mepolizumab was stronger than benralizumab (ROR 108.04 [95%CI, 96.09–121.47] vs 26.83 [95%CI, 18.91–38.06]). Comparing with mepolizumab and benralizumab, we found the proportion of serious adverse events in mepolizumab was both greater than benralizumab in each age group (≤20, 20–65, and ≥ 65). The median onset time of mepolizumab was 280 days (interquartile range [IQR] 1–367 days). Analysis of FAERS data identified anti-IL-5 mAbs-associated AEs, and our findings supported continuous clinical monitoring, pharmacovigilance, and further studies of anti-IL-5 mAbs. In addition, clinicians may be more aware of the limitations of use in package inserts of anti-IL-5 mAbs: Not for relief of acute bronchospasm or status asthmaticus. Because of some limitations in the FAERS such as self-reports from patients and other confounding factors, the safety of anti-IL-5 mAbs needed more studies in different dimensions, especially the risk of cancer.
Quality of life in ovarian cancer patients treated with bevacizumab: a meta-analysis
Creators: name: Wu, Di
name: He, Jianrong
name: Shi, Ping
name: Wang, Zirong
name: Liu, Min
name: Liu, Anchang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Cell Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Bevacizumab is widely used in ovarian cancer due to its ability to extend survival. The addition of bevacizumab to chemotherapy may increase the toxicities that affect quality of life (QOL). To investigate the impact of bevacizumab on QOL during the increased survival, we conducted a meta-analysis of randomized controlled trial (RCT). We systematically searched PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov. for RCTs comparing the QOL of bevacizumab plus chemotherapy (BEV-CT) versus chemotherapy (CT) in ovarian cancer. The primary outcome was the difference in change in QOL from baseline to follow-up between groups. Four RCTs involving 3454 patients were included in this meta-analysis. There was no difference in change in QOL between patients treated with BEV-CT and CT at the end of follow-up (pooled SMD= −00.05; 95%CI = −00.34 to 0.23; P = 0.71). Subgroup analyses showed similar results in the frontline and recurrent setting of ovarian cancer. This is the first meta-analysis investigating QOL in ovarian cancer patients treated with bevacizumab. The extended survival associated with bevacizumab is not accompanied by a significant deterioration in QOL. Combined with the efficacy and safety outcomes, these results further support the clinical benefit of bevacizumab for ovarian cancer.
title: Functional classification of undernourished populations in Guatemala: description of the social, economical, environmental and nutritional characteristics of labourer's families residing in coffee plantations
Creators: name: Valverde, VE
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1980

description: Efforts have been made in Central American countries to define the nature and size of the nutrition problem with more regional and population specificity, to orient the selection of types, the size and geographical location of government programmes. This work describes the nutritional status, social, economical and environmental characteristics of agricultural labourers and their families residing on coffee plantations in Western Guatemala, and present an analysis of seasonal effects on children's growth. The results show very marked growth retardation in children 6 to 59 months. Socio-economic problems are related to the low level of the legal minimum wage and the lack of other income-generating activities for adults. Isolation limits their possi-bilities for making full use of government programmes in health, education and social security and other private services, such as open markets and lower price shops, available in nearby towns. Problems of quantity and quality of water, crowding, excreta and trash disposal and control of domestic animals contribute to the burden of infection with its final effects on nutritional and health status. The analyses of socio-economic variables, commonly used in cross-sectional surveys, and their relationship with various indexes of nutritional status show that most of them do not discriminate specific characteristics related to poorer nutritional status within the farms. Only differences in total family cash income, type of estate work of the head of the house-hold, and use of shoes by the head of the household are statis-tically significant, but the size of the differences are not of practical importance for planning purposes. It is concluded that, for action programmes, families residing in coffee plantations can be regarded as an homogeneous group. In the light of the present political, social and economic constraints in Guatemala, a series of action programmes are suggested to improve living conditions in these populations.
Data mining and analysis of the adverse events derived signals of 4 gadolinium-based contrast agents based on the US Food and drug administration adverse event reporting system
Creators: name: Wang, Lu
name: Wang, Yinglin
name: Zhao, Quan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Mental Health

description: To detect and analyze risk signals of the drug-related adverse events (AEs) of 4 gadolinium-based contrast agents (GBCAs) (gadopentetate dimeglumine (Gd-DTPA), gadobenate dimeglumine (Gd-BOPTA), gadoteridol (Gd-HP-DO3A), and gadobutrol (Gd-BT-DO3A)) according to the US Food and Drug Administration Adverse Event Reporting System (FAERS) database and ensure the clinical safety. The AEs that are associated with the 4 GBCAs were collected from the FAERS database from 2004Q1 to 2022Q3. The risk signals were mined using reporting odds ratio (ROR) and proportional reporting ratio (PRR). 424 risk signals were excavated, in which 151 risk signals were associated with Gd-DTPA, 93 risk signals were related to Gd-BOPTA, 79 risk signals were relevant to Gd-HP-DO3A, and 101 risk signals were associated with Gd-BT-DO3A. The AE signals involved 20 system organ classes (SOCs). Two of the top four SOCs were identical, namely ‘skin and subcutaneous tissue disorders’ and ‘general disorders and administration site conditions.’ The safety signals of 4 GBCAs were detected, and the SOCs associated with the AEs of the 4 GBCAs were different. Besides, some AEs obtained in this study were not mentioned in the package inserts, which need more attention and research to ensure the clinical safety.
Characteristics of adverse drug reactions induced by flutamide and bicalutamide: a real-world pharmacovigilance study using FAERS
Creators: name: Sun, Yu
name: Xu, Tao
name: Zhu, Suyan
name: Xu, Hongbin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Flutamide and bicalutamide are indicated for the management of prostate metastatic carcinoma. The current study evaluated the adverse drug reactions related to flutamide and bicalutamide in a real-world setting. To quantify the signals of flutamide and bicalutamide associated adverse events (AEs), we used the US Food and Drug Administration Adverse Event Reporting System (FAERS) for this pharmacovigilance study using established pharmacovigilance methods. A total of 2711 AEs of flutamide were investigated as the primary suspected; 522 AEs were related to prostate cancer. A total of 4459 AEs were investigated as the primary suspected for bicalutamide; 2251 AEs were related to prostate cancer. The analysis demonstrated 29 signals for flutamide and 84 for bicalutamide. Liver function test was the most common AEs for flutamide, and malignant neoplasm progression was the most common for bicalutamide. The signal strength of Dementia Alzheimer’s type was 26.53 (17.89–39.35) and 26.33 (607.34), which had the highest strength for flutamide. Anti-androgen withdrawal syndrome exhibited the strongest signal for bicalutamide. Generating awareness of rare AEs that were not listed on the label is critical. The analysis of the AE signals may provide support for prescribing flutamide and bicalutamide.
Pregnancy-related adverse events associated with statins: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS)
Creators: name: Wu, Tingxi
name: Shi, Yanfeng
name: Zhu, Bin
name: Li, Dandan
name: Li, Zhe
name: Zhao, Zhigang
name: Zhang, Yang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Statins, previously rated as pregnancy category X agents, were contraindicated during pregnancy due to the teratogenic effects observed in animal studies. However, it is still controversial whether statins have detrimental impact on pregnant women or not, and some studies even suggest a potential benefit of statin use against pregnancy complications. The aim of this study was to explore whether maternal exposure to statins is associated with increased rates of pregnancy-related adverse events (AEs), including abortion, abortion spontaneous, preterm birth, low birth weight, stillbirth/fetal death, and fetal complications. Data from 1 January 2004 to 30 June 2022 were extracted through the U.S. FDA Adverse Event Reporting System (FAERS) database, to conduct disproportionality analysis and Bayesian analysis by reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) algorithms. To identify the potential risks of pregnancy-related AEs, each statin was compared to all the other drugs, all the other statins, and the reference drugs (fenofibrate and evolocumab). A total of 477 cases involving pregnancy-related AEs associated with stains were submitted to the FAERS database by healthcare professionals. No obvious disproportionate association of abortion, abortion spontaneous, or stillbirth/fetal death was identified for all statins during gestation. In comparison with all the other drugs, lovastatin showed an increased risk of fetal complications (ROR = 2.45, 95% CI, 1.22–4.95; IC025 = 0.63), and pravastatin demonstrated increased risks of preterm birth (ROR = 4.89, 95% CI, 3.65–6.54; IC025 = 1.69) and low birth weight (ROR = 9.60, 95% CI, 5.56–16.56; IC025 = 1.88). Similar results were found when compared lovastatin or pravastatin with fenofibrate. Furthermore, statins were associated with higher proportion of fetal complications and preterm birth when comparing with evolocumab. Statins did not increase the risk of pregnancy-related AEs, including abortion, abortion spontaneous, or stillbirth/fetal death. However, we did find significant disproportionality signals for preterm birth and low birth weight associated with pravastatin, and lovastatin was related to a higher proportion of fetal complications. The results in this study may provide evidence on the safety of statins during pregnancy, which need to be verified in further investigations.
Real-world safety of icosapent ethyl: analysis based on spontaneous reports in FAERS database
Creators: name: Cai, Haixia
name: Jia, Beixi
name: Fu, Zhonghua
name: Chen, Boya
name: Liu, Yinping
name: Zhao, Shujuan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: The triglyceride-lowering drug, icosapent ethyl (IPE), was granted a new indication for the reduction of atherosclerotic cardiovascular disease risk in 2019. This study aimed to investigate the safety profile of IPE by mining the FDA Adverse Event Reporting System (FAERS) database. The reporting odds ratio was used to analyze IPE’s adverse events (AEs) based on the FAERS data from July 2012 to December 2022. We described the characteristics of AE reports and evaluated the clinical prioritization of AEs. Then we defined and analyzed nine interested adverse drug reactions (ADRs) in both overall and subgroups, and investigated the times to onset. The findings of our study strengthen the evidence for an increased risk of atrial fibrillation using IPE. IPE alone may not increase the risk of bleeding unless combined with antithrombotic drugs. Similar to statins, IPE alone can increase the risk of musculoskeletal pain, drug-related hepatic disorders, and hyperglycemia, but the risk could not double when IPE was combined with statins. Most ADRs occur in the early stage of treatment. This study provides a comprehensive real-world safety profile of IPE, which indicates that IPE is well-tolerated.
Uniwersytet jako projekt kulturowy
Creators: name: Kobylarek, Aleksander
Publisher: name: figshare
Year: 2014
Subjects: Education

description: Th e text is facing the problem of changes in the Polish university aft er the granting mass process in
the years 90’ of the 20th century. Th e idea of the Humboldtian university is compared to changes,
made by the Bologna process. Th e old idea was a kind of culture project, which had potential of
unifi cation the European area of education much more than the Bolonia process. In the article
there are set together the strength and weakness of both ideas
Evaluating Ubrogepant-related adverse events using the FDA adverse event reporting system
Creators: name: Cao, Bing
name: Gu, Shanshan
name: Shen, Zhisen
name: Zhang, Yuna
name: Shen, Yiming
name: Chen, Hang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Migraine has a high prevalence in the population and accounts for 12% of primary headaches. Ubrogepant is used for the treatment of acute migraine, and although some clinical trials have demonstrated the safety of Ubrogepant, its long-term safety in a large sample of the population remains to be investigated. We collected data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. We used reporting odds ratio (ROR), the proportional reporting ratio (PRR), the information component (IC) and the empirical Bayes geometric mean (EBGM) to evaluate Ubrogepant-induced adverse events (AEs). We screened out 2,067 reports of Ubrogepant as primary suspected (PS) and 6,190 reports of Ubrogepant-induced AEs as PS. Our results showed that Ubrogepant-induced AEs targeted 4 system organ classes (SOCs), detected 32 Preferred terms (PTs) signals in 9 SOCs, including common Ubrogepant label consistent with Migraine, Nausea, Somnolence, Paraesthesia oral and Dizziness, It also includes the AEs of Hemiparesis, Mental impairment, Dysstasia, Tinnitus, Chest pain, Cold sweat, Neck pain, etc. that have not been demonstrated in previous studies. Our study identified new AEs that have not been reported, which provides a new guidance to deepen the comprehension of the safety of Ubrogepant.
Frequentist Evaluation of Small DSGE Models
Creators: name: Bårdsen, Gunnar
name: Fanelli, Luca
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Earth and Environmental Sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Medicine

description: This article proposes a new evaluation approach for the class of small-scale “hybrid” new Keynesian dynamic stochastic general equilibrium (NK-DSGE) models typically used in monetary policy and business cycle analysis. The empirical assessment of the NK-DSGE model is based on a conditional sequence of likelihood-based tests conducted in a vector autoregressive (VAR) system, in which both the low- and high-frequency implications of the model are addressed in a coherent framework. If the low-frequency behavior of the original time series of the model can be approximated by nonstationary processes, stationarity must be imposed by removing the stochastic trends. This gives rise to a set of recoverable unit roots/cointegration restrictions, in addition to the short-run cross-equation restrictions. The procedure is based on the sequence “LR1→LR2→LR3,” where LR1 is the cointegration rank test, LR2 is the cointegration matrix test, and LR3 is the cross-equation restrictions test: LR2 is computed conditional on LR1 and LR3 is computed conditional on LR2. The Type I errors of the three tests are set consistently with a prefixed overall nominal significance level. A bootstrap analog of the testing strategy is proposed in small samples. We show that the information stemming from the individual tests can be used constructively to uncover which features of the data are not captured by the theoretical model and thus to rectify, when possible, the specification. We investigate the empirical size properties of the proposed testing strategy by a Monte Carlo experiment and show the empirical usefulness of our approach by estimating and testing a monetary business cycle NK-DSGE model using U.S. quarterly data. Supplementary materials for this article are available online.
Ocular adverse events of cenegermin used in neurotrophic keratopathy: an analysis of the FDA adverse event reporting system database
Creators: name: Li, Yunfei
name: Yang, Haiyun
name: Gao, Yuan
name: He, Weimin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Cenegermin, a recombinant human nerve growth factor, is an orphan drug approved for neurotrophic keratitis. The safety information on the label is incomplete, and the adverse reactions noted are mostly mild and tolerable. However, the occurrence of painful epithelial plagues and irreversible corneal deposits after cenegermin usage have been reported. Real-world data on long-term ocular safety are lacking. We aimed to assess the cenegermin-associated eye safety profile in the FDA pharmacovigilance database. The signals of cenegermin-related ocular adverse events (AEs) from 2018 to 2022 were quantified using the reporting odds ratio (ROR) and information component (IC). The grading system was used to prioritize the signals. We identified 3288 cases of cenegermin-related ocular AEs and 56 positive ocular-related signals. Fifty unexpected signals of ocular AE were identified. Eye ulcer was classified as a designated medical event. Twenty AEs, including corneal perforation, eye infection, corneal deposits, and eye inflammation, were recognized as important medical event. The median onset time for ocular AEs was 6 days (interquartile range [IQR]: 1–29 days). This study revealed new cenegermin-related ocular AE signals. Clinical practice requires close monitoring to early identify and manage adverse reactions that may cause occurrence of serious irreversible consequences.
Polycyclic Aromatic Hydrocarbon Profiles of Some Brands of Canned Fish in the Nigerian Market
Creators: name: Chukwujindu M. A. Iwegbue
name: Overah, Loretta C.
name: Godswill O. Tesi
name: Bassey, Francisca I.
name: Martincigh, Bice S.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: Neuroscience
subject: Engineering
subject: Biochemistry

description: ABSTRACTConcentrations and profiles of polycyclic aromatic hydrocarbons (PAHs) were determined in selected popular brands of canned fish (mackerel, sardine, and tuna) consumed in Nigeria with a view to providing information on the health risk associated with consumption of these products. The concentrations of PAHs were measured by gas chromatography equipped with flame ionization detection (GC-FID) after dichloromethane/hexane extraction and clean-up. The concentrations of Σ16 PAHs in these brands of canned fish varied from 174.6 to 350.8 μg/kg, 187.4 to 592.5 μg/kg, and 204 to 264.6 μg/kg for mackerel, sardine, and tuna, respectively. Benzo(a)pyrene was detected in 48% of the investigated brands at concentrations higher than the maximum tolerable limit of 5 μg/kg. The daily intake of PAHs from the consumption of any brand of these canned fish ranged from not detected (nd) to 54.3 ng BaP/kg bw/day, nd to 56.4 ng PAH2/kg bw/day, nd to 86.4 ng PAH4/kg bw/day, and nd to 153.7 ng PAH8/kg bw/day. The estimated margin of exposure (MOE) values (BaP-MOE, PAH2-MOE, PAH4-MOE, and PAH8-MOE) in a significant proportion of the brands was less than 10,000, which indicates a potential health risk for the consumers of these brands of canned fish.
title: Environmental Stress Cracking (ESC) and Slow Crack Growth (SCG) of PE-HD induced by external fluids
Creators: name: Schilling, Markus
Publisher: name: UNSPECIFIED
Year: 2020

description: High-density polyethylene (PE-HD) is widely used as a packaging material. Typical applications are pipes and containers for storage and transport of dangerous goods. For these applications, the understanding of the craze-crack damage mechanisms slow crack growth (SCG) and environmental stress cracking (ESC) is of importance. Since these mechanisms are considered to be the major causes of failure, their understanding is essential for inspection and release of those materials. A well-established test method for the assessment of these damage mechanisms is the full-notch creep test (FNCT). It is used in this study for a detailed investigation of crack propagation phenomena in PE-HD container materials under the influence of different fluids such as air, water and aqueous detergent solutions (Arkopal N 100) as well as biodiesel and diesel. Based on the results of the FNCT, a classification scheme of different fluids is proposed, which allows for an assignment of the respective damage mechanisms. Hereby, it is differentiated between (i) inert, (ii) purely surface-active and (iii) additionally sorptive, bulk-active fluids with respect to SCG. If the test fluid changes the intrinsic properties (at the surface or in the bulk), the damage mechanism is addressed to ESC behavior. In FNCT investigations, stress, temperature and specimen geometry were varied systematically. In addition to the time to failure as common measure for the resistance of a PE-HD type against crack propagation, specimen elongation was considered in detail. Several imaging techniques were applied for fracture surface analysis of specimens tested in FNCT to gain novel information on SCG and ESC behavior. From height profiles obtained by laser scanning microscopy (LSM) and information on surface structures from scanning electron microscopy (SEM), indicators for the differentiation of the crack propagation mechanisms could be derived. Based on the LSM data, an algorithm for the distinction between ductile shear deformation and brittle crack growth as dominating failure mechanism was developed. Imaging techniques were also used for determination of crack propagation rates, which were related to time-resolved FNCT elongation data. From the time-resolved determination of crack lengths of partly damaged FNCT specimens, an increasing length of craze zone with a progressively propagating crack was revealed for the first time. This relation of crack and craze zones was specified by fracture mechanical considerations.
Risk-Based Methodology for Pre-Evaluation of Environmental Technologies for Sustainable Revitalization of Post-Industrial Sites
Creators: name: Włodzimierz A. Sokół
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Microbiology

description: ABSTRACTRevitalization of post-industrial sites is a challenge. Holistic approaches based on integrated regional environmental management are necessary to prevent sites from becoming restricted-use liabilities. Maintaining site attractiveness and preventing ongoing environmental degradation are important aspects of sustainability in urban areas. This article describes methods for and examples of integrated regional environmental management systems. The incorporation of information on risk drivers, spatial and temporal components of exposure to various risks, and establishment of remediation and restoration priorities, allows such integrated regional management systems to provide best practices for decision-making in the context of multiple risk influences and a range of site end-uses. Methods allowing pre-evaluation of responses that correct site degradation and maximize the range of possible end uses are valuable tools for sustainable development. Evaluation of potential impacts, costs, and benefits of responses and end-use alternatives is important for achieving sustainable environmental, economic, social, and land-use objectives. Criteria for pre-evaluation of energy commitment, material requirements, and emissions to soil, water and air are considered for method development. The sample technologies were selected from databases collected from a framework of international projects.
A price-directed heuristic for the economic lot scheduling problem
Creators: name: Adelman, Daniel
name: Barz, Christiane
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: The article formulates the well-known economic lot scheduling problem (ELSP) with sequence-dependent setup times and costs as a semi-Markov decision process. Using an affine approximation of the bias function, a semi-infinite linear program is obtained and a lower bound for the minimum average total cost rate is determined. The solution of this problem is directly used in a price-directed, dynamic heuristic to determine a good cyclic schedule. As the state space of the ELSP is non-trivial for the multi-product setting with setup times, the authors further illustrate how a lookahead version of the price-directed, dynamic heuristic can be used to construct and dynamically improve an approximation of the state space. Numerical results show that the resulting heuristic performs competitively with one reported in the literature.
Risk-Based Methodology for Pre-evaluation of Environmental Technologies for Sustainable Revitalization of Post-Industrial Sites
Creators: name: Włodzimierz A. Sokół
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Microbiology

description: ABSTRACTRevitalization of post-industrial sites is a challenge. Holistic approaches based on integrated regional environmental management are necessary to prevent sites from becoming restricted-use liabilities. Maintaining site attractiveness and preventing ongoing environmental degradation are important aspects of sustainability in urban areas. This paper describes methods for and examples of integrated regional environmental management systems. The incorporation of information on risk drivers, spatial and temporal components of exposure to various risks, and establishment of remediation and restoration priorities, allows such integrated regional management systems to provide best practices for decision-making in the context of multiple risk influences and a range of site end-uses. Methods allowing pre-evaluation of responses that correct site degradation and maximize the range of possible end uses are valuable tools for sustainable development. Evaluation of potential impacts, costs, and benefits of responses and end-use alternatives is important for achieving sustainable environmental, economic, social, and land-use objectives. Criteria for pre-evaluation of energy commitment, material requirements, and emissions to soil, water and air are considered for method development. The sample technologies were selected from databases collected from a framework of international projects.
Frequentist Evaluation of Small DSGE Models
Creators: name: Bårdsen, Gunnar
name: Fanelli, Luca
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Earth and Environmental Sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Medicine

description: This paper proposes a new evaluation approach for the class of small-scale ‘hybrid’ New Keynesian Dynamic Stochastic General Equilibrium (NK-DSGE) models typically used in monetary policy and business cycle analysis. The empirical assessment of the NK-DSGE model is based on a conditional sequence of likelihood-based tests conducted in a Vector Autoregressive (VAR) system, in which both the low and high frequency implications of the model are addressed in a coherent framework. If the low frequency behavior of the original time series of the model can be approximated by non-stationary processes, stationarity must be imposed by removing the stochastic trends. This gives rise to a set of recoverable unit roots/cointegration restrictions, in addition to the short-run cross-equation restrictions. The procedure is based on the sequence ‘LR1→LR2→LR3’, where LR1 is the cointegration rank test, LR2 the cointegration matrix test and LR3 the cross-equation restrictions test: LR2 is computed conditional on LR1 and LR3 is computed conditional on LR2. The type-I errors of the three tests are set consistently with a pre-fixed overall nominal significance level. A bootstrap analogue of the testing strategy is proposed in small samples. We show that the information stemming from the individual tests can be used constructively to uncover which features of the data are not captured by the theoretical model and thus to rectify, when possible, the specification. We investigate the empirical size properties of the proposed testing strategy by a Monte Carlo experiment and show the empirical usefulness of our approach by estimating and testing a monetary business cycle NK-DSGE model using U.S. quarterly data. J.E.L. C5, E4, E5
A price-directed heuristic for the economic lot scheduling problem
Creators: name: Adelman, Daniel
name: Barz, Christiane
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: The article formulates the well-known economic lot scheduling problem (ELSP) with sequence-dependent setup times and costs as a semi-Markov decision process. Using an affine approximation of the bias function, a semi-infinite linear program is obtained and a lower bound for the minimum average total cost rate is determined. The solution of this problem is directly used in a price-directed, dynamic heuristic to determine a good cyclic schedule. As the state space of the ELSP is non-trivial for the multi-product setting with setup times, the authors further illustrate how a lookahead version of the price-directed, dynamic heuristic can be used to construct and dynamically improve an approximation of the state space. Numerical results show that the resulting heuristic performs competitively with one reported in the literature.
title: 01_2529
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A Price-Directed Heuristic for the Economic Lot Scheduling Problem
Creators: name: Adelman, Daniel
name: Barz, Christiane
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: We formulate the well-known economic lot scheduling problem (ELSP) with sequence-dependent setup times and costs as a semi-Markov decision process. Using an affine approximation of the bias function, we obtain a semi-infinite linear program, determining a lower bound for the minimum average total-cost rate. The solution of this problem is directly used in a price-directed, dynamic heuristic to determine a good cyclic schedule. As the state space of the ELSP is non-trivial for the multi-product setting with setup times, we further illustrate how a lookahead version of the price-directed, dynamic heuristic can be used to construct and dynamically improve an approximation of the state space. Numerical results show that the resulting heuristic performs competitively with the one suggested by Dobson (1992).
title: aposimoō (ἀποσιμόω)
Creators: name: Tosi, Maria Beatrice
Publisher: name: Laboratorio di Storia, Archeologia, Epigrafia e Tradizione dell'antico (SAET) - Scuola Normale Superiore
Year: 2024
Subjects: subject: FOS: Humanities
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Analisi della voce aposimoō (ἀποσιμόω).