cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Parallel Computing Approach for Identifying Retinitis Pigmentosa Modifiers in Drosophila Using Eye Size and Gene Expression Data
Creators: name: Metah, Chawin
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Bioinformatic methods development
Other information and computing sciences not elsewhere classified

description: For many years, researchers have developed ways to diagnose degenerative disease in the retina by utilizing multiple gene analysis techniques. Retinitis pigmentosa (RP) disease can cause either partially or totally blindness in adults. For that reason, it is crucial to find a way to pinpoint the causes in order to develop a proper medication or treatment. One of the common methods is genome-wide analysis (GWA). However, it cannot fully identify the genes that are indirectly related to the changes in eye size. In this research, RNA sequencing (RNA-seq) analysis is used to link the phenotype to genotype, creating a pool of candidate genes that might associate with the RP. This will support future research in finding a therapy or treatment to cure such disease in human adults.
 Using the Drosophila Genetic Reference Panel (DGRP) – a gene reference panel of fruit fly – two types of datasets are involved in this analysis: eye-size data and gene expression data with two replicates for each strain. This allows us to create a phenotype-genotype map. In other words, we are trying to trace the genes (genotype) that exhibit the RP disease guided by comparing their eye size (phenotype). The basic idea of the algorithm is to discover the best replicate combination that maximizes the correlation between gene expression and eye-size. Since there are 2N possible replicate combinations, where N is the number of selected strains, the original implementation of sequential algorithm was computationally intensive.
 The original idea of finding the best replicate combination was proposed by Nguyen et al. (2022). In this research, however, we restructured the algorithms to distribute the tasks of finding the best replicate combination and run them in parallel. The implementation was done using the R programming language, utilizing doParallel and foreach packages, and able to execute on a multicore machine. The program was tested on both a laptop and a server, and the experimental results showed an outstanding improvement in terms of the execution time. For instance, while using 32 processes, the results reported up to 95% reduction in execution time when compared with the sequential version of the code. Furthermore, with the increment of computational capabilities, we were able to explore and analyze more extreme eye-size lines using three eye-size datasets representing different phenotype models. This further improved the accuracy of the results where the top candidate genes from all cases showed connection to RP.
Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein
Creators: name: Cho, Yoon Young
name: Kwon, Oh-Hoon
name: Park, Myoung Kyu
name: Kim, Tae-Wan
name: Chung, Sungkwon
Publisher: name: Columbia University
Year: 2019
Subjects: Alzheimer's disease--Genetic aspects
Presenilins
Cholesterol
Molecular biology

description: Familial Alzheimer’s disease (FAD)-associated presenilin 1 (PS1) serves as a catalytic subunit of γ-secretase complex, which mediates the proteolytic liberation of β-amyloid (Aβ) from β-amyloid precursor protein (APP). In addition to its proteolytic role, PS1 is involved in non-proteolytic functions such as protein trafficking and ion channel regulation. Furthermore, postmortem AD brains as well as AD patients showed dysregulation of cholesterol metabolism. Since cholesterol has been implicated in regulating Aβ production, we investigated whether the FAD PS1-associated cholesterol elevation could influence APP processing. We found that in CHO cells stably expressing FAD-associated PS1 ΔE9, total cholesterol levels are elevated compared to cells expressing wild-type PS1. We also found that localization of APP in cholesterol-enriched lipid rafts is substantially increased in the mutant cells. Reducing the cholesterol levels by either methyl-β-cyclodextrin or an inhibitor of CYP51, an enzyme mediating the elevated cholesterol in PS1 ΔE9-expressing cells, significantly reduced lipid raft-associated APP. In contrast, exogenous cholesterol increased lipid raft-associated APP. These data suggest that in the FAD PS1 ΔE9 cells, the elevated cellular cholesterol level contributes to the altered APP processing by increasing APP localized in lipid rafts.
Defect-induced spin-glass magnetism in incommensurate spin-gap magnets
Creators: name: Andrade, Eric C.
name: Vojta, Matthias
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study magnetic order induced by non-magnetic impurities in quantum paramagnets with incommensurate host spin correlations. In contrast to the well-studied commensurate case where the defect-induced magnetism is spatially disordered but non-frustrated, the present problem combines strong disorder with frustration and, consequently, leads to spin-glass order. We discuss the crossover from strong randomness in the dilute limit to more conventional glass behavior at larger doping, and numerically characterize the robust short-range order inherent to the spin-glass phase. We relate our findings to magnetic order in both BiCu2PO6 and YBa2Cu3O6.6 induced by Zn substitution.
description: 6 pages, 5 figs, (v2) real-space RG results added; discussion extended, (v3) final version as published
Utah State University Botanical Center Stream Master Plan
Creators: name: Schults, Daniel Willard
Publisher: name: Utah State University
Year: 2012

description: The Utah State University Botanical Center Stream Master Plan is a design to assist Utah State University Botanical Center (USUBC) administration in fulfilling their goals of community outreach and education, implementing sustainable practices and creating aesthetically beautiful areas for public enjoyment. These goals are met through updating the USUBC master plan to account for the newly built man-made stream as well as other future buildings. Trails, overlooks and information nodes are part of the new master plan. The planting plan includes representations of six natural plant communities found in Northern Utah. Additionally, the stream design improves the water quality of USUBC ponds on site. All of these designs will contribute to USUBC goals. The Utah State University Botanical Center Master Plan and Planting Plan is a plan B thesis project.
Differential Impacts of HIV status on short-term fertility desires among couples in Rakai, Uganda
Creators: name: Song, Xiaoyu
name: Grilo, Stephanie A.
name: Mathur, Sanyukta
name: Lutalo, Tom
name: Ssekubugu, Robert
name: Nalugoda, Fred
name: Santelli, John S.
Publisher: name: Columbia University
Year: 2019
Subjects: Fertility, Human--Social aspects
HIV-positive persons--Social conditions

description: Background
Fertility desires of female and male partners in current relationships are often correlated. We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates.

Methods
Participants were couples (15–49 years old) enrolled in the Rakai Community Cohort Study, from 2011 to 2013 (n = 2,291). Cohen’s kappa coefficient was used to measure the correlation of female and male partners’ short-term fertility desires (measured as ‘wanting a child in the next 12 months’), in both total sample and stratified serostatus groups. HIV serostatus and additional characteristics of female and male partners were included in Poisson regression models to estimate the rate ratios (RR) for each partner’s short-term fertility desires. Individual and partner characteristics included HIV status, partner HIV status, age in years, partner age in years, educational attainment, number of living children, community of residence, and socioeconomic status (SES).

Results
Short-term fertility desires among female and male partners were moderately associated (Kappa = 0.37, p-value<0.001). The association was weakest among female sero-positive and male sero-negative couples (Kappa = 0.29, p-value<0.001). When adjusting for parity and other covariates in the model, women’s short-term fertility desires were significantly associated with their positive sero-status regardless of male partners’ sero-status (adjRR = 1.58, p<0.001 for F+M-; adjRR = 1.33, p = 0.001 for F+M+; in comparison with F-M-). Men’s short-term fertility desires were significantly associated with their positive sero-status, in addition to their female partners’ positive sero-status (adjRR = 1.23 with p-value = 0.022 for F-M+; adjRR = 1.42 with p-value<0.001 for F+M-; adjRR = 1.26 with p-value<0.001 for F+M+; in comparison with F-M-). When the differential effect of parity was included in the model, similar associations remained for both female and male partners when the number of living children was small, but largely reduced when the number of living children was large (3 or more).

Conclusion
Female and male partners in couple dyads demonstrated moderate agreements about short-term fertility desires. The HIV seropositive status of female partners was most strongly associated with short-term fertility desires of both genders, and this association was even stronger for women who had few or no living children.
Dentatorubral-Pallidoluysian Atrophy: An Update
Creators: name: Carroll, Liam S.
name: Massey, Thomas H.
name: Wardle, Mark
name: Peall, Kathryn J.
Publisher: name: Columbia University
Year: 2018
Subjects: Neurology
Nervous system--Degeneration
Movement disorders
Myoclonus
Ataxia

description: Aim: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare, autosomal dominantly inherited disorder characterised by myoclonus, epilepsy, ataxia and dementia. Diagnosis is challenging due to the heterogeneous presentation and symptomatic overlap with other spinocerebellar ataxias. Symptoms vary according to age of onset, with a mean age-at-onset at 31. A CAG repeat expansion in the gene ATN1 results in neuronal intranuclear inclusions, variable neuronal loss and astrocytosis in the globus pallidus, dentate and red nuclei. No disease-modifying or curative treatments are currently available

Methods: We performed an online literature search using PubMed for all articles published on the topics of DRPLA or ATN1 over the last 10-years in an English Language format. Where these articles cited other research as support for findings, or statements, these articles were also reviewed. Contemporary articles from related research fields (e.g. Huntington's Disease) were also included to support statements.

Results: Forty-seven articles were identified, 10 were unobtainable and 10 provided no relevant information. The remaining 27 articles were then used for the review template: 7 case reports, 7 case series, 6 model system articles (1 review article), 4 population clinical and genetic studies (1 review article), 2 general review articles and 1 human gene expression study. Other cited articles or research from related fields gave a further 42 articles, producing a total of 69 articles cited: 15 case series (including 8 family studies), 14 model systems (1 review article), 14 population clinical and genetic studies (2 review articles), 10 case reports, 8 clinical trials/guidelines, 4 genetic methodology articles, 3 general review articles and 1 human gene expression study.

Discussion: DRPLA remains an intractable, progressive, neurodegenerative disorder without effective treatment. Early recognition of the disorder may improve patient understanding, and access to services and treatments. Large-scale studies are lacking, but required to characterise the full allelic architecture of the disorder in all populations, and the heterogeneous phenotypic spectrum including neuroimaging findings, possible biomarkers and responses to treatment.
New horizons in multidimensional diffusion: The Lorentz gas and the Riemann Hypothesis
Creators: name: Dettmann, Carl P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: The Lorentz gas is a billiard model involving a point particle diffusing deterministically in a periodic array of convex scatterers. In the two dimensional finite horizon case, in which all trajectories involve collisions with the scatterers, displacements scaled by the usual diffusive factor $\sqrt{t}$ are normally distributed, as shown by Bunimovich and Sinai in 1981. In the infinite horizon case, motion is superdiffusive, however the normal distribution is recovered when scaling by $\sqrt{t\ln t}$, with an explicit formula for its variance. Here we explore the infinite horizon case in arbitrary dimensions, giving explicit formulas for the mean square displacement, arguing that it differs from the variance of the limiting distribution, making connections with the Riemann Hypothesis in the small scatterer limit, and providing evidence for a critical dimension $d=6$ beyond which correlation decay exhibits fractional powers. The results are conditional on a number of conjectures, and are corroborated by numerical simulations in up to ten dimensions.
description: Now 23 pages, including a new section 2 proposing that the mean square displacement differs from the variance of the limiting distribution for this model; there are also changes to notation, figures and references
"Where are the moderate Muslims?" : fraught Muslim positionalities in post-9/11 New York
Creators: name: Mohibullah, Huma
Publisher: name: University of British Columbia
Year: 2017

description: This dissertation examines how the ongoing repercussions of the September 11, 2001 attacks on The World Trade Center (“9/11”), and the haunting legacy of the Twin Towers’ collapse, have affected the religious subjectivities, identity positionings and spatial perceptions of American Muslims living in New York City. Anti-Muslim conservatives continue to perceive Islam as an inherently extremist political system and cynically ask, “Where are the moderate Muslims?” In this framing, Muslim Americans are often de-Americanized and treated as outsiders in the United States—a narrative that was exacerbated during Donald Trump's presidential campaign. Based on 24 months of fieldwork, my dissertation analyzes, first, how Muslim New Yorkers navigate the suggestion that religious moderation among Muslims is a rarity and that Islam is antithetical to liberal democratic values. I show that while some reject the use of “moderate” in Islamophobic discourses, others position themselves as moderate and progressive Muslims using particular religious interpretations and practices (especially those emphasizing gender egalitarianism and LGBT inclusion), as well as civic engagement, public events, and other forms of political action. My analysis also pays attention to the spatial dimension of Muslim New Yorkers’ senses of self, first in relation to ongoing surveillance by the NYPD, and secondly, in relation to the World Trade Center. Using examples such as the highly controversial "Ground Zero Mosque," it shows how Muslim subjectivities are embodied and spatialized through affective relationships with certain places.
Validation of VO2 Prediction Equations in Aquatic Treadmill (ATM) Exercise
Creators: name: Hadley, Scott
Publisher: name: Utah State University
Year: 2012

description: The purpose of this study is to validate the accuracy of the regression models created by Greene et al. (2011) for the prediction of oxygen consumption for aquatic treadmill (ATM) exercise at different speeds and jet resistances.
Twenty-one healthy individuals completed this study. Prior to testing V02peak, height, weight, and body composition were measured. At least 48 hours following V02peak testing participants completed five three-minute submaximal trials in the ATM. Speed was self-selected between 53 and 201 m-min-I to represent light, moderate, and somewhat hard conditions. Water jet.,resistance was between 0-80%. ATM speed and jet resistance were randomized for the trials. Participants rested for three minutes between trials. Oxygen consumption (V02) was measured continuously during trials. Measured V02 was compared to predicted V02.
Out of 105 trials completed in the ATM, 90 resulted in a greater V02 than predicted by the Greene et al. (2011) equations. Mean and predicted V02 for all ATM trials differed by 3.6 ml - kg-I - min-I (27.7 ± 9.1 mI- kg-I - min-I vs 24.1 ± 7.2 ml - kg-I - min-I). Mean and predicted V02 for trials withjet resistance between 0-25% differed by 3.1 mI- kg-I - min-I ,(25.7 ± 7.8 vs 22.6 ± 6.8 ml - kg-I - min-I, respectively). Mean and predicted V02 for trials with 25-100% jet resistance differed by 3.8 ml- kg-I - min-I (28.5 ± 9.5 vs 24.7 ± 7.2 mI- kg-I - min-I, respectively). Paired (-test and generalized estimating equations (GEE) showed a significant correlation (p< .001) between predicted and measured V O2 for both equations. There was no significant correlation (p> 0.05) between V02, trial number, and BMI. Using percent-predicted value, the 0-25% equation underestimated V02 by 14% and the 25-100% equation underestimated V02 by 15%. The effect size for the 0-25 equation was .43, and the effect size for the 25-100 equation was .45.
Our findings demonstrate the Greene equations underestimate V02 by an average of3.6 ml • kg-1 • min-I. This value tends to be greater than reported for previously published land treadmill (TM) running equations. Rehabilitation specialists and performance coaches may want to consider this degree of precision when using these equations for their clients.
The effect of attractiveness and different types of humor on percieves trustworthiness
Creators: name: Klil Ram
name: Brimer, Michal
name: Vorobey, Tal
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: זוהי הרשמה מראש למחקר במסגרת הקורס פסיכולוגיה ניסויית.
Comparative Analysis of Healthcare Expenditure in the United States and Canada
Creators: name: Anazia, Chris N.
Publisher: name: Utah State University
Year: 2012

description: Total healthcare expenditures and expenditures as a percentage of GDP have been substantially higher in the U.S. than in Canada between 1975 – 2008. Hospitalcare, physician and clinical services, and drug prescription expenditures have been the principal components contributing to growth in healthcare expenditures in the U.S. compared to Canada. This study reviews the literature on increasing healthcare costs and establishes some comparative and descriptive analysis for high healthcare costs in the two countries during this time period. The study also analyses and compares the growth of healthcare costs.
Tardive Dyskinesia-like Syndrome Due to Drugs that do not Block Dopamine Receptors: Rare or Non-existent: Literature Review
Creators: name: D’Abreu, Anelyssa
name: Friedman, Joseph H.
Publisher: name: Columbia University
Year: 2018
Subjects: Tardive dyskinesia
Antidepressants
Anticonvulsants
Parasympatholytic agents
Antihistamines
Neurology

description: Background: Although tardive dyskinesia (TD) is most commonly defined as a movement disorder caused by chronic exposure to dopamine-receptor-blocking drugs (DRBDs), it has also been thought to result from exposure to some non-DRBDs.

Methods: We critiqued many reviews making the association between non-DRBDs and a TD-like syndrome and almost all case reports. We checked whether cases met criteria for the diagnosis of TD-like syndrome and whether DRBDs had been excluded.

Results: We found that both tricyclic antidepressants and selective serotonin reuptake inhibitor antidepressants may unmask or exacerbate TD after prior exposure to or with concurrent use of DRBDs. We found support for its existence outside of this context to be extremely weak.

Discussion: There is little evidence that drugs other than DRBDs by themselves cause a TD syndrome; most reported cases appear to occur as a result of a “priming” effect induced by a DRBD, which is later unmasked.
Additional file 1 of A systematic review and meta-analysis of the epidemiological characteristics of COVID-19 in children
Creators: name: Vosoughi, Fardis
name: Makuku, Rangarirai
name: Tantuoyir, Marcarious M.
name: Yousefi, Farbod
name: Shobeiri, Parnian
name: Karimi, Amirali
name: Alilou, Sanam
name: LaPorte, Ronald
name: Tilves, Curtis
name: Nabian, Mohammad Hossein
name: Yekaninejad, Mir Saeed
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Quality assessment of the articles included in the final analysis of the study using the Newcastle-Ottawa Quality Assessment Scale (NOS). Supplementary Figure 1. Graphical representation of the quality assessment of included studies based on checklist items.
From stochastic single atomic switch to nanoscale resistive memory device
Creators: name: Geresdi, A.
name: Halbritter, A.
name: Gyenis, A.
name: Makk, P.
name: Mihály, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Solid state ionic conductors are good candidates for the next generation of nonvolatile computer memory elements. Such devices have to show reproducible resistance switching at reasonable voltage and current values even if scaled down to the nanometer sizes. Here we study the switching characteristics of nanoscale junctions created between a tungsten tip and a silver film covered by a thin ionic conductor layer. Atomic-sized junctions show spectacular current induced switching characteristics, but both the magnitude of the switching voltage and the direction of the switching vary randomly for different junctions. In contrast, for somewhat larger junctions with diameters of a few nanometers a well defined, reproducible switching behavior is observed which is associated with the formation and destruction of nanoscale channels in the ionic conductor surface layer. Our results define a low size limit of 3 nm for reliable ionic nano-switches, which is well below the resolution of recent lithographic techniques.
Development of a Ripple Rejection Controller for DC Commutated Motors
Creators: name: Atkin, Spencer M.
Publisher: name: Utah State University
Year: 2012

description: The requirement of modern systems to be quiet and run smoothly increases production costs. The manufacture and purchase of high quality motors that meet these demands becomes increasingly costly. By using the ever increasing computer power available in micro-controllers, at the same costs, it is possible to use current sensing to develop control adjustments which decrease power ripples caused by the commutators of basic DC commutated motors. These ripples if left unmitigated propagate through to torque ripples which then increase the acoustic noise level present.
The Helmholtz Hierarchy: Phase Space Statistics of Cold Dark Matter
Creators: name: Tassev, Svetlin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a new formalism to study large-scale structure in the universe. The result is a hierarchy (which we call the "Helmholtz Hierarchy") of equations describing the phase space statistics of cold dark matter (CDM). The hierarchy features a physical ordering parameter which interpolates between the Zel'dovich approximation and fully-fledged gravitational interactions. The results incorporate the effects of stream crossing. We show that the Helmholtz hierarchy is self-consistent and obeys causality to all orders. We present an interpretation of the hierarchy in terms of effective particle trajectories.
description: 43 pages; added sections 7 and 8, which include interpretation as particle trajectories
Effects of Choice of Reinforcement on the On-­Task Behavior of Kindergarten Students with Developmental Delays
Creators: name: Binette, Karen
Publisher: name: Utah State University
Year: 2012

description: A high degree of external control is maintained in classrooms serving students with behavioral and developmental disabilities. However, decision making is an important developmental objective related to personal control and dignity. Choice making and discriminating preferred over less preferred outcomes is an important skill that is seldom taught to students with developmental disabilities. Previous research includes studies conducted in clinical settings or with populations with severe disabilities.
Effects of Training Peer Tutors to Deliver Praise Statements, Prompts, and Correction Procedures on Academic Skills of Students Who Have Severe to Moderate Disabilities
Creators: name: Brooks, Lyndi
Publisher: name: Utah State University
Year: 2012

description: Peer tutors have been utilized in many settings to work with various individuals, including those with disabilities. There has not been considerable research into the training of peer tutors for students who have severe disabilities in the junior high setting and the effect the training has on the performance of students with disabilities. The purpose of this project was to determine whether training junior high school-­‐aged peer tutors on the use of praise statements, a prompt hierarchy, correction procedures, and data collected to track tutee performance increased academic skills of students with disabilities. Seven peer tutors participated. Five students (i.e., tutees) with disabilities were involved. Multiple tutors worked with each tutee according to a block schedule. By training peer tutors on the use of specific skills, such as use of praise statements, prompt hierarchies, error correction procedures, and data collection, peer tutors showed increased tutorial skills as evidenced by tutor observation scores. The students with disabilities evidenced increased academic skills as measured by differences in post-­‐ test scores compared to pre-­‐test scores in curriculum-­‐based assessments. Both tutors and tutees reported high levels of satisfaction following the peer tutor experience. The project provided data on the effectiveness of peer tutoring for increasing skills of students with severe to moderate disabilities in a junior high setting.
The leading root of the partial theta function
Creators: name: Sokal, Alan D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: Mathematical Physics (math-ph)
subject: Classical Analysis and ODEs (math.CA)
subject: Complex Variables (math.CV)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 05A15 (Primary), 05A19, 05A20, 05A30, 05C30, 11B65, 11P84, 30D20, 33D15, 33D65 (Secondary)

description: I study the leading root x_0(y) of the partial theta function Θ_0(x,y) = \sum_{n=0}^\infty x^n y^{n(n-1)/2}, considered as a formal power series. I prove that all the coefficients of -x_0(y) are strictly positive. Indeed, I prove the stronger results that all the coefficients of -1/x_0(y) after the constant term 1 are strictly negative, and all the coefficients of 1/x_0(y)^2 after the constant term 1 are strictly negative except for the vanishing coefficient of y^3.
description: LaTeX2e, 22 pages including one Postscript figure. Version 2 includes a few new brief remarks; published in Advances in Mathematics
Clinical spectrum of LMNA-associated Type 2 Familial Partial Lipodystrophy. A systematic review
Creators: name: Sánchez-Iglesias, Sofía
name: Cobelo-Gómez, Silvia
name: Díaz-López, Everardo Josué
name: Castro, Ana I.
name: Prado-Moraña, Teresa
name: Araujo-Vilar, David
name: Antía Fernández-Pombo
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Endocrinology, Diabetes, and Metabolism
subject: Diabetes
subject: Hypertriglyceridemia
subject: LMNA
subject: Laminopathies
subject: Insulin resistance
subject: Lipodystrophy

description: To explore the published data regarding the clinical characterisation of type 2 Familial Partial Lipodystrophy
Hydraulic Modeling: Pipe Network Analysis
Creators: name: Datwyler, Trevor T.
Publisher: name: Utah State University
Year: 2012

description: Water modeling is becoming an increasingly important part of hydraulic engineering. One application of hydraulic modeling is pipe network analysis. Using programmed algorithms to repeatedly solve continuity and energy equations, computer software can greatly reduce the amount of time required to analyze a closed conduit system. Such hydraulic models can become a valuable tool for cities to maintain their water systems and plan for future growth. The Utah Division of Drinking Water regulations require cities to maintain hydraulic models of their culinary water systems, and before additional connections can be made to the water system, a licensed professional engineer must model the additions to water system and determine if the additional connections can be made without negatively impacting the existing system. This is known as the Hydraulic Modeling Rule, or R309-511 in the State Administrative Code.
The State of Utah has set the minimum pressure and flow requirements a culinary water system must meet. Before cities can qualify for state or federal funding to complete water system improvement projects, they must first demonstrate through a hydraulic model that they are providing the required minimum flows and pressures for all the service connections within the system, or that their improvement project will remediate any deficiencies to comply with the State’s pressure and flow requirements.
The protective role of self-compassion in the self-objectification process
Creators: name: Sarda Elisa
name: Wollast, Robin
name: Riemer, Abigail Rose
Publisher: name: Open Science Framework
Year: 2021
Subjects: subject: Social Psychology
subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: This study analyzes the protective role of self-compassion on key variables of the objectification model.
Real analyticity away from the nucleus of pseudorelativistic Hartree-Fock orbitals
Creators: name: Dall'Acqua, Anna
name: Fournais, Søren
name: Sørensen, Thomas Østergaard
name: Stockmeyer, Edgardo
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 35B65, 35J10, 81Q05, 81V55, 81V70, 35Q40

description: We prove that the Hartree--Fock orbitals of pseudorelativistic atoms, that is, atoms where the kinetic energy of the electrons is given by the pseudorelativistic operator sqrt{-Delta+1}-1, are real analytic away from the origin. As a consequence, the quantum mechanical ground state of such atoms is never a Hartree-Fock state. Our proof is inspired by the classical proof of analyticity by nested balls of Morrey and Nirenberg. However, the technique has to be adapted to take care of the non-local pseudodifferential operator, the singularity of the potential at the origin, and the non-linear terms in the equation.
description: 44 pages; 2 figures. (1) The result is now extended to the multiconfiguration case (see Remark 1.2 and Theorem 1.3). (2) Acknowledgements added. (3) To appear in 'Analysis & PDE'
Transition from coherent mesoscopic single particle transport to proximity Josephson-current
Creators: name: Geresdi, A.
name: Halbritter, A.
name: Mihály, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The transport through a metal-superconductor interface is governed by a special charge conversion process, the Andreev reflection, where each incident electron drags another electron with itself to form a Cooper pair. At the normal side a hole is left behind dressed by superconducting correlations. For a low transparency interface the simultaneous transfer of two charges is strongly suppressed leading to a reduced conductance. Here we demonstrate that this reduced conductance can be turned to an infinite one by tuning the nanoscale geometry. Creating variable size nanojunctions between a thin metallic film and a superconducting tip we study how multiple phase-coherent scatterings enhance the superconducting correlations at the normal side. By increasing the coherent volume of carriers initially the transmission through the interface is continuously enhanced. However, as the phase-coherent volume reaches the opposite surface of the thin film a resonator is formed, and a robust transition is induced due to Cooper pair condensation.
Behavioral Life-Cycle Models Under Alternative Demographic Regimes
Creators: name: Harris, Timothy F.
Publisher: name: Utah State University
Year: 2012

description: Social security in the United States will encounter financial strains due to an aging population. The decreasing worker to retiree ratio will reduce retirement benefits relative to today’s benefits so long as the tax rate and eligibility age are not altered. Policy makers assume that they should make policies to maintain the current benefit levels.
In contrast to this assumption, this paper does not presume that policy makers should preserve current benefits. An analysis of the required tax rate to maintain lifetime utility across the current and future demographic regimes is undertaken rather than just a calculation of the tax rate needed to maintain present benefits. A comparison of life-cycle consumption models across the present and future demographic regimes shows that the tax rate should actually decrease 2-6 percentage points in order to equate lifetime utility. This result is opposite of the prescribed tax increase to maintain retirement benefits. This finding holds with varying assumptions of intertemporal decision making including exponential discounting (as in standard life-cycle models), hyperbolic discounting, and short planning horizons.
This counter-intuitive result is driven by the inability of a social security program (with a below market internal rate of return) to improve welfare for the models mentioned above under the present demographic regime. The future demographic regime only reduces the internal rate of return and thus makes the program less advantageous. Therefore, in order to maintain utility across regimes, the pension program must be reduced.
Towards a classroom community: Interaction, culture and mindfulness in Second Language Learning
Creators: name: Hollenback, Janae Suzanne
Publisher: name: Utah State University
Year: 2012

description: This portfolio is a compilation of the author’s works while a student in the Master of Second Language Teaching Program at Utah State University. The core of this work is the Teaching Philosophy, which is prefaced with the author’s observations of “what works” and “what doesn’t work” in education based on her experience as a student. This is followed by a brief description of the author’s intended professional environment. The Teaching Philosophy itself explores various research and other influences which have inspired the author’s direction and preferences for effective language teaching. The three artifacts in this portfolio constitute the author’s research in the areas of culture, language, and literacy. To conclude an annotated bibliography reviews sources that have influenced the artifacts and teaching philosophy.
Products of Independent Non-Hermitian Random Matrices
Creators: name: O'Rourke, Sean
name: Soshnikov, Alexander
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60B20

description: For fixed $m>1$, we consider $m$ independent $n \times n$ non-Hermitian random matrices $X_1, ..., X_m$ with i.i.d. centered entries with a finite $(2+η)$-th moment, $ η>0.$ As $n$ tends to infinity, we show that the empirical spectral distribution of $n^{-m/2} \*X_1 X_2 ... X_m$ converges, with probability 1, to a non-random, rotationally invariant distribution with compact support in the complex plane. The limiting distribution is the $m$-th power of the circular law.
description: The paper is accepted for publication in Electronic Journal of Probability. In the final version we fixed a small technical gap in the proofs of Theorem 15 and Lemma 19 and added the reference to the 2009 paper by Girko and Vladimirova
Effective use of Interactive Learning Modules in Classroom Study for Computer Science Education
Creators: name: Jamwal, Goldee
Publisher: name: Utah State University
Year: 2012

description: The National Science Foundation (NSF) is spending substantial resources to improve science, technology, engineering, and mathematics (STEM) education in the United States. The ultimate goal of these programs is to produce students with a better knowledge of math and science and who are more likely to pursue careers in STEM fields. Interactive learning modules can be used in the classroom environment for effective learning.
This study examines the learning preferences of Logan High School (located in Logan, Utah) students and evaluates the impacts of using interactive learning modules with classroom lectures compared to other traditional methods of teaching.
Toward an Economics of the Slowdown in the West
Creators: name: Phelps, Edmund S.
Publisher: name: Columbia University
Year: 2019
Subjects: Economics
Economics--Decision making
Job satisfaction

description: The West is in crisis – and so is economics. Economies are in a 50-year slowdown. Rates of return on investment have shrunk. Wages – and incomes generally – are stagnating for most people. Job satisfaction is down, especially among the young, and more working-age people are unwilling or unable to participate in the labor force. Yet economists have been largely mute on the underlying causes of this crisis and what, if anything, can be done to restore economic vigor. It is safe to say that the causes are not well understood. And they will not be understood until economists finally engage in the task of reshaping how economics is taught and practiced. In particular, the profession needs three revolutions that it still resists.
Design and Testing of a Turbidity Sensor for Grain Size Measurements
Creators: name: Martin Cid, Sara Rebeca
Publisher: name: Utah State University
Year: 2013

description: Grain-size analysis is a measurement of the size distribution of individual particles in a soil sample. The major features of grain-size analysis are the destruction or dispersion of soil aggregates into discrete units by chemical, mechanical, or ultrasonic means and the separation of particles according to size limits by such means as sieving and sedimentation, as well as other methods.
Soil particles span a large size range, varying from boulders (exceeding 0.25 m in size) down to submicron clays (Grain-size distribution curves are used extensively by civil engineers to evaluate materials used for foundations, road fills, and other construction purposes. And when it comes to analyzing fine-grained soils like clays, which particle size has been shown to have an important effect on permeability, shear strength, and consolidation behavior of soil, the measurement of grain-size becomes of great importance for geotechnical engineering.
On decays of Z' into unparticle stuff
Creators: name: Kozlov, G. A.
name: Gorbunov, I. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the decay of a Z' - boson into U -unparticle and a photon. The extended Landau-Yang theorem is used. The clear photon signal would make the decay Z' \rightarrow γU as an additional contribution mode for study of unparticle physics.
description: 11 pages, 3 figures, paper accepted for publication by Advances in High Energy Physics journal
Urban Trail System Planning in the Western United States: An Analysis of the Trail-Specific Planning Efforts of Four Cities that Have Implemented Urban Trail Systems
Creators: name: Richley, Kenneth C.
Publisher: name: Utah State University
Year: 2012

description: States in the Western United States are growing at rates outpacing the rest of the nation. This growth is placing pressure on communities to develop their current open space for residential or commercial use. As cities develop a comprehensive open space plans, several elements arise. One critical element is connectivity. This connectivity is most often realized in the form of greenways. In many cities these greenways contain urban trail systems that provide significant recreation and connectivity benefits.
This thesis investigates the current recommended models used to plan for greenway, synthesizes them into a recommended model process, and analyzes case studies of four cities that have implemented urban trail systems against this model framework.
The case studies include cities in the West with populations between 50,000 and 100,000 that are not part of a greater metropolitan area with demonstrated planning and implementation of urban trail systems. This selection provides the most relevance to smaller cities in the West that are beginning open space planning efforts.
Developing a recommended model process will aid smaller communities in planning for greenways by providing a step-by-step process from concept to implementation. This guide can provide a roadmap for communities that do not have experience with these planning models and can be used by citizens and non-planning professionals as well.
Three critical factors arose that were common to all case studies. First, the need to follow a trail-specific planning process. The communities studied had all made efforts to plan for trails apart from their general or comprehensive plans. Second, the planning process must have a robust public participation process. This ensures that community needs are met and buy-in is achieved for the implementation process. Lastly, the early identification of trail corridors is essential to the long-term planning process. This ensures that there are no surprises for the community when implementation begins. These factors should receive particular attention from communities wishing to develop urban trail systems.
Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis
Creators: name: Bansal, Mukesh
name: He, Jing
name: Peyton, Michael
name: Kustagi, Manjunath
name: Iyer, Archana
name: Comb, Michael
name: White, Michael
name: Minna, John D.
name: Califano, Andrea
Publisher: name: Columbia University
Year: 2019
Subjects: Adenocarcinoma
Molecular biology
Lungs--Cancer--Molecular aspects
Proteomics

description: To understand drug combination effect, it is necessary to decipher the interactions between drug targets—many of which are signaling molecules. Previously, such signaling pathway models are largely based on the compilation of literature data from heterogeneous cellular contexts. Indeed, de novo reconstruction of signaling interactions from large-scale molecular profiling is still lagging, compared to similar efforts in transcriptional and protein-protein interaction networks. To address this challenge, we introduce a novel algorithm for the systematic inference of protein kinase pathways, and applied it to published mass spectrometry-based phosphotyrosine profile data from 250 lung adenocarcinoma (LUAD) samples. The resulting network includes 43 TKs and 415 inferred, LUAD-specific substrates, which were validated at >60% accuracy by SILAC assays, including “novel’ substrates of the EGFR and c-MET TKs, which play a critical oncogenic role in lung cancer. This systematic, data-driven model supported drug response prediction on an individual sample basis, including accurate prediction and validation of synergistic EGFR and c-MET inhibitor activity in cells lacking mutations in either gene, thus contributing to current precision oncology efforts.
4-dimensional Spin-foam Model with Quantum Lorentz Group
Creators: name: Han, Muxin
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the quantum group deformation of the Lorentzian EPRL spin-foam model. The construction uses the harmonic analysis on the quantum Lorentz group. We show that the quantum group spin-foam model so defined is free of the infra-red divergence, thus gives a finite partition function on a fixed triangulation. We expect this quantum group spin-foam model is a spin-foam quantization of discrete gravity with a cosmological constant.
description: 23 pages, 3 figures, references added
Additional file 1 of Association between oral intake magnesium and sarcopenia: a cross-sectional study
Creators: name: Yang, Shih-Wei
name: Chen, Yuan-Yuei
name: Chen, Wei-Liang
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Computational Biology

description: Additional file 1 Supplement Table 1. Standard measurement protocol of muscle quality index in NHANES.
Literacy Skills of Preschool Children with Hearing Loss
Creators: name: Sanders, Nicole
Publisher: name: Utah State University
Year: 2013

description: Historically, children with hearing loss have struggled to attain levels of literacy commensurate with typical hearing peers (Marschark, 2007), however, due to the use of advanced hearing technology (i.e., hearing aids and cochlear implants), children with hearing loss have demonstrated improved literacy outcomes (Johnson & Goswami, 2010). Standardized literacy, language, cognitive assessments and speech perception measures were administered to 11 preschool-age children using either hearing aids or cochlear implants. Descriptive analysis was provided regarding performance on each assessment. Correlations were made between early literacy and speech, language, and cognitive standardized test scores, speech perception measures, and hearing-related factors. Results indicated that preschool children with hearing loss are performing within the average range on early literacy measures. There is also variability among children with hearing loss on their early literacy performance. Auditory and visual cognitive processing is correlated with early literacy skills.