cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Energy companies as key stakeholders in the low-carbon energy transition
Creators: name: Creutin, Jean-Dominique
name: Hewitt, Richard J
name: Tøfte, Lena
name: Ramos, Maria-Helena
name: Borga, Marco
Publisher: name: Zenodo
Year: 2016
Subjects: energy companies; energy transition; private sector; boundary agents; renewable energies; stakeholders

description: It is now widely recognised that the transition to a low-carbon economy, agreed by Paris climate conference delegates in 2015 to be necessary to keep global warming to the safest possible limits, will require a major societal transformation. Though much work remains to be done, the scientific foundations are well-established, and policy makers are beginning to set out a framework by which such a transformation might be achieved. Yet the missing piece of the implementation puzzle, the implementing actors, and especially the private sector, has received insufficient attention. This chapter describes stakeholder engagement work undertaken with the private energy sector, principally in France, Norway and Italy, as part of Work Package 2 (WP2) “Climate Related Energies” of the COMPLEX FP7 Project. This WP focused on investigating the influence of climate, weather and hydrology on the integration of renewables in electricity systems. It specifically dealt with wind, solar and hydropower sources. In the following sections, the aims and methods of the private sector stakeholder engagement process in these countries are described, the results of the process are analysed in detail, and a wider discussion is presented. In the final section of this chapter, we draw together these experiences to form a series of recommendations for future engagement of the private sector in climate and energy policy.
Irrational acts: Maternal death, women's agency, and the obligation to care in Uganda
Creators: name: Boyd, Lydia
Publisher: name: Wiley
Year: 2024

description: Following the recommendation of the WHO in the mid-2000s, the Ugandan government banned traditional birth attendants (TBAs) and encouraged all women to give birth in biomedical clinics. Yet in rural Luuka district, about half of women still give birth at home or with the assistance of lay providers. This article examines women's healthcare behavior to better understand decisions that are characterized as irrational by officials, in particular women's choices to delay care, move between providers, and defer health decisions to others. Building on anthropological interest in the relationality of care, this article explores how women compel the care of others, especially under conditions of healthcare scarcity and in contexts outside clinical settings. A focus on the gendered nature of kin-based care provides insight into how acts often characterized as irrational can be modes of action for women in ways that exceed a policy focus on healthcare choice and autonomy.
PubChem Ranker
Creators: name: Windsor, Jacob
Publisher: name: figshare
Year: 2016
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Computational Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: Originally intended for use in a university project to investigate a large dataset of volatile organic compounds (VOCs). Many of VOCs in the dataset had very little information for them and so the need to filter out VOCs with little information arose.
This simple program ranks a dataset of compounds (in XML) with CAS numbers by the number of biosystems or bioassays in PubChem. This is useful in investigating a large dataset where little information is know for many of the individual data points as it gives a better starting point.
A usage guide is available on the README at https://github.com/jacobwindsor/pubchem-ranker.
Blurring Boundaries: A Proposed Research Agenda for Ethical, Legal, Social, and Historical Studies at the Intersection of Infectious and Genetic Disease.
Creators: name: Greene, Jeremy
name: Mooney, Graham
name: Kahn, Jeffrey
name: Mathews, Debra J H
name: Juengst, Eric Thomas
name: Wilbanks, Rebecca
name: Henry, Leslie Meltzer
name: Bollinger, Juli
name: White, Alexandre
name: Geller, Gail
name: Jose, Sheethal
name: Hutler, Brian
name: Mastroianni, Anna C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Contemporary understanding of the mechanisms of disease increasingly points to examples of "genetic diseases" with an infectious component and of "infectious diseases" with a genetic component. Such blurred boundaries generate ethical, legal, and social issues and highlight historical contexts that must be examined when incorporating host genomic information into the prevention, outbreak control, and treatment of infectious diseases.
The Great Secession: Ethno-National Rebirth and the Politics of Turkish–German Belonging
Creators: name: Özvatan, Özgür
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: belonging
subject: boundary studies
subject: exclusion
subject: far right
subject: Germany
subject: identity
subject: immigrant integration
subject: inclusion politics
subject: narrative theory
subject: Turkey
subject: 300 Sozialwissenschaften

description: Germany is facing a contemporary mainstreaming of the far right, which has a long tradition of wanting “Turks out!” Turkish immigrants have been the main strangers in Germany following the guest-worker treaty signed in 1961, physically close as friends, yet culturally distant as foes. From September 2015 onwards, German–Turkish politics of belonging, the Turkish issue, underwent a contentious period resulting in secessions between German and Turkish authorities in September 2017. Against this background, this article asks: How did mainstream political actors in Germany emplot the Turkish issue while a far-right challenger party sought to establish a far-right narrative of ethno-national rebirth? The temporal unfolding of the Turkish issue is explored by drawing on media analysis (n = 1120), interpretive process-tracing and narrative genre analysis of claims raised by political actors in German and Turkish newspapers. In order to visualize how the Turkish issue evolved between 2000 and 2017 in media discourse, 546 articles in the mainstream quality newspaper Frankfurter Allgemeine Zeitung were collected. The Great Secession period between 2015 and 2017 was selected for an in-depth case study. To conduct interpretive process-tracing and narrative genre analysis of this case, another 574 articles in the German Süddeutsche Zeitung and Turkish Hürriyet were analysed. In so doing, this article contributes to (1) the study of belonging and identity by adopting a novel approach to boundary studies, combining narrative genre analysis with Habermas’ communicative action theory, and (2) the study of political strategies of adapting, ignoring or demarcating far-right contenders by, again, introducing a narrative approach to political communication and mobilization processes. The analysis shows that, in the first stage of the Great Secession period, inclusionary and exclusionary boundaries competed, while in later stages inclusionary boundaries were cast aside by exclusionary boundaries after reputable mainstream party-political actors adopted and thus legitimized far-right story elements.
Human factors considerations of Interaction between wearers and intelligent lower-limb prostheses: a prospective discussion
Creators: name: Huang, He
name: Liu, Ming
name: Yuan, Jing
name: Feng, Jing
name: Bai, Xiaolu
Publisher: name: Springer Nature
Year: 2024

description: Compared to traditional lower-limb prostheses (LLPs), intelligent LLPs are more versatile devices with emerging technologies, such as microcontrollers and user-controlled interfaces (UCIs). As emerging technologies allow a higher level of automation and more involvement from wearers in the LLP setting adjustments, the previous framework established to study human factors elements that affect wearer-LLP interaction may not be sufficient to understand the new elements (e.g., transparency) and dynamics in this interaction. In addition, the increased complexity of interaction amplifies the limitations of the traditional evaluation approaches of wearer-LLP interaction. Therefore, to ensure wearer acceptance and adoption, from a human factors perspective, we propose a new framework to introduce elements and usability requirements for the wearer-LLP interaction. This paper organizes human factors elements that appear with the development of intelligent LLP technologies into three aspects: wearer, device, and task by using a classic model of the human-machine systems. By adopting Nielsen’s five usability requirements, we introduce learnability, efficiency, memorability, use error, and satisfaction into the evaluation of wearer-LLP interaction. We identify two types of wearer-LLP interaction. The first type, direct interaction, occurs when the wearer continuously interacts with the intelligent LLP (primarily when the LLP is in action); the second type, indirect interaction, occurs when the wearer initiates communication with the LLP usually through a UCI to address the current or foreseeable challenges. For each type of interaction, we highlight new elements, such as device transparency and prior knowledge of the wearer with the UCI. In addition, we redefine the usability goals of two types of wearer-LLP interaction with Nelson’s five usability requirements and review methods to evaluate the interaction. Researchers and designers for intelligent LLPs should consider the new device elements that may additionally influence wearers’ acceptance and the need to interpret findings within the constraints of the specific wearer and task characteristics. The proposed framework can also be used to organize literature and identify gaps for future directions. By adopting the holistic usability requirements, findings across empirical studies can be more comparable. At the end of this paper, we discuss research trends and future directions in the human factors design of intelligent LLPs.
Meeting Student Needs for Multivariate Data Analysis: A Case Study in Teaching an Undergraduate Multivariate Data Analysis Course
Creators: name: Wagaman, Amy
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Modern students encounter large, messy datasets long before setting foot in our classrooms. Many of these students need to develop skills in exploratory data analysis and multivariate analysis techniques for their jobs after college, but such topics are not covered in traditional introductory statistics courses. This case study describes my experience in designing and teaching an undergraduate course on multivariate data analysis with minimal prerequisites, using real data, active learning, and other interactive activities to help students tackle the material. Multivariate topics covered include clustering and classification (among others) for exploratory data analysis and an introduction to algorithmic modeling. Supplementary materials for this article are available online.
A Gestural Account of Mandarin Tone Sandhi
Creators: name: Yi, Hao
Publisher: name: Zenodo
Year: 2014
Subjects: Tonal Gesture
Mandarin Tone Sandhi
Articulatory Phonology
Electromagnetic Articulography

description: Recently tones have been analyzed as articulatory gestures, which may be coordinated with segmental gestures (Gao 2008). Using Electromagnetic Articulometry (EMA), this paper investigates the timing of tonal gestures and articulatory gestures in Mandarin tone sandhi under the framework of Articulatory Phonology (AP). Analyses of the timing patterns show that purported neutralized phonological contrast can nonetheless exhibit coordinative differences in Mandarin tone sandhi. Furthermore, it is likely that a bias towards the underlying tone (lexical Tone3) is responsible for the incomplete neutralization between Tone2 and the output of third tone sandhi (henceforth T3S) . The rest of the paper is organized as follows: Section 2 offers background on Mandarin tone sandhi and the motivation for the current study; Section 3 lays out the theoretical framework, i.e. AP and two major AP-based accounts that inspired this paper; Section 4 formulates the hypotheses; Section 5 covers the methodology, including the experiment design and statistical methods; Section 6 presents the results, and Section 7 provides closing discussion and some final thoughts.
description: This working paper is copyrighted, and is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) - see https://creativecommons.org/licenses/by-nc-nd/4.0/
Everything (marine) you need to know from the 2014 World Parks Congress
Creators: name: Wehner, Nick
Publisher: name: figshare
Year: 2016
Subjects: subject: 80505 Web Technologies (excl. Web Search)
subject: FOS: Computer and information sciences
subject: Uncategorized

description: The OpenChannels Team live blogged throughout the 2014 World Parks Congress. John Davis was on-scene in Syndey, updating us on the conference's Marine Theme. We also curated the most useful and interesting tweets coming out of the conference in order to save them from disappearing into the ether. You can see everything as it happened in the live blog's archive at http://openchannels.org/chat/wpc-2014. This not-so-live blog contains relevant highlights for the ocean and coastal community.
Additional file 12 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12: Figure S6. Maximum Likelihood tree of arginase and agmatinase sequences. The scale bar indicates the average number of amino acid substitutions per site. The anchor sequences and methods are in Materials and methods.
title: Detection of UAP with a Nano Satellite
title: Detektion von UAP mit einem Nanosatelliten
title: A feasibility study
titleType: Subtitle
Creators: name: Reitemeyer, Malte
name: Weinmann, Felix
Publisher: name: Universität Würzburg
Year: 2022
Subjects: subject: 629 Andere Fachrichtungen der Ingenieurwissenschaften

description: Research on Unidentified Aerial Phenomena; 1
Peroxisome-targeted and tandem repeat multimer expressions of human antimicrobial peptide LL37 in Pichia pastoris
Creators: name: Siwei Xiao
name: Yanyun Gao
name: Xiaolong Wang
name: Shen, Wei
name: Jinjia Wang
name: Xiangshan Zhou
name: Menghao Cai
name: Yuanxing Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Although the human antimicrobial peptide LL37 has a broad spectrum of antimicrobial activities, it easily damages host cells following heterologous expressions. This study attempted two strategies to alleviate its damage to host cells when expressed in Pichia pastoris using the AOX1 promoter. Tandem repeat multimers of LL37 were first designed, and secretion expression strains GS115-9K-(DPLL37DP)n (n = 2, 4, 6 and 8) containing different copies of the LL37 gene were constructed. However, LL37 tandems still killed the cells after 96 hr of induction. Subsequently, peroxisome-targeted expression was performed by adding a peroxisomal targeting signal 1 (SKL) at the C-terminus of LL37. The LL37 expression strain GS115-3.5K-LL37-SKL showed no significant inhibition in the cells after induction. Antibacterial activity assays showed that the recombinant LL37 expressed in peroxisomes had good antimicrobial activities. Then, a strain GS115-3.5K-LL37-GFP-SKL producing LL37, green fluorescent protein, and SKL fusion proteins was constructed, and the fusion protein was confirmed to be targeting the peroxisomes. However, protein extraction analysis indicated that most of the fusion proteins were still located in the cell debris after cell disruption, and further studies are required to extract more proteins from the peroxisome membrane.
How Do Users of Activity Tracking Technologies Perceive the Data Privacy Environment in the EU?
Creators: name: Fietkiewicz, Kaja J.
name: Ilhan, Aylin
Publisher: name: Zenodo
Year: 2020
Subjects: activity tracking technologies
data privacy
gdpr
health and fitness

description: With the omnipresent digitalization and quantification of our everyday life, data privacy became an important topic in research, politics and legislation. In order to contain the possible risks of uncontrolled data collection and its possible misuse, it is important to ensure a sustainable data privacy environment. Here, one of the most important aspects is an efficient and effective legislature. In May 2018, when the General Data Protection Regulation (GDPR) came into force, the EU made an important step towards improving the European data privacy environment. In this study there are investigated both, the awareness and the perception of the GDPR by the users of fitness tracking technologies. This investigation focuses on people from the EU using a fitness tracking application as well as a fitness tracking device, which usually collect a lot of personal and health-related data. Most of the fitness tracking users are aware of the GDPR but do not believe that it will improve the reality of data privacy. Even though there appears to be limited belief in the sustainability of the European data privacy environment (in terms of a positive development of consumers' data privacy), this does not necessarily affect the everyday usage of activity tracking applications and wearables.
Additional file 11 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11: Figure S5. Maximum Likelihood tree of PRK sequences. The scale bar indicates the average number of amino acid substitutions per site. The anchor sequences and methods are in Materials and methods.
Nutzen und Grenzen der Erfassung und Kategorisierung digitaler Editionen. Oder: Fifty Shades of Grey?
Creators: name: Schulz, Daniela
Publisher: name: Zenodo
Year: 2022
Subjects: Digitale Editionen
Editionsmatrix
Kategorisierung
CLARIAH-DE
textplus

description: Präsentation im Rahmen des virtuellen DH-Kolloquiums der BBAW am 09.04.2021
Peroxisomes targeted and tandem repeat multimer expressions of human antimicrobial peptide LL37 in Pichia pastoris
Creators: name: Siwei Xiao
name: Yanyun Gao
name: Xiaolong Wang
name: Shen, Wei
name: Jinjia Wang
name: Xiangshan Zhou
name: Menghao Cai
name: Yuanxing Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Although the human antimicrobial peptide LL37 has a broad spectrum of antimicrobial activities, it easily damages host cells following heterologous expressions. This study attempted two strategies to alleviate its damage to host cells when expressed in Pichia pastoris using the AOX1 promoter. Tandem repeat multimers of LL37 were first designed, and secretion expression strains GS115-9 K-(DPLL37DP)n (n = 2, 4, 6 and 8) containing different copies of the LL37 gene were constructed. However, LL37 tandems still killed the cells after 96 h of induction. Subsequently, peroxisome-targeted expression was performed by adding a peroxisomal targeting signal 1 (SKL) at the C-terminus of LL37. The LL37 expression strain GS115-3.5 K-LL37-SKL showed no significant inhibition in the cells after induction. Antibacterial activity assays showed that the recombinant LL37 expressed in peroxisomes had good antimicrobial activities. Then, a strain GS115-3.5 K-LL37-GFP-SKL producing LL37, green fluorescent protein and SKL fusion proteins was constructed, and the fusion protein was confirmed to be targeting the peroxisomes. However, protein extraction analysis indicated that most of the fusion proteins were still located in the cell debris after cell disruption, and further studies are required to extract more proteins from the peroxisome membrane.
Simulating cardiac fluid dynamics in the human heart.
Creators: name: Peskin, Charles S
name: Segars, W Paul
name: Smith, Margaret Anne
name: Puelz, Charles
name: Wells, David R
name: Griffith, Boyce E
name: Vavalle, John P
name: Sturgeon, Gregory M
name: Rossi, Simone
name: Davey, Marshall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid-structure interactions (FSIs). However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the valves are limited in their abilities to predict valve performance, capture fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac FSI in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart's microstructure. Further, it is the first FSI model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure-volume loops that automatically capture isovolumetric contraction and relaxation, and that its responses to changes in loading conditions are consistent with the Frank-Starling mechanism. These complex relationships emerge intrinsically from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical interventions. They also can provide platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients.
Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California
Creators: name: Kai-Chung Cheng
name: Park, Hye-Kyung
name: Afua O. Tetteh
name: Zheng, Daisy
name: Ouellette, Nicholas T.
name: Nadeau, Kari C.
name: Hildemann, Lynn M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: We measured real-time and integrated PM2.5 inside eight occupied single-family homes in Fresno, California to evaluate how turbulent air mixing and pollutant removal caused by a filter-based air purifier influences the levels of fine particles in everyday indoor environments. In each home, we used a real-time monitor to log PM2.5 levels every 5 min over 12 weeks during which air purifiers were operating, except for a designed 3-day shutdown period for baseline measurements. We assessed how the operation of air purifiers changed the patterns of the frequency distributions for short-term (5 min) concentrations, which included spikes produced by sporadic indoor activities or emissions. This allowed us to examine the reduction effectiveness of air purifiers on concentrations of both recently emitted and well-mixed background aerosols. We observed a systematic change in the 5-min PM2.5 distributions in different homes—while air purifiers reduced 96% of the 5-min concentrations, they increased the magnitudes of the top 4%, representing transient concentration peaks. This phenomenon is consistent with what would be theoretically expected based on passive scalar turbulence in fluid physics. We also collected gravimetric filter samples for PM2.5 composition, finding mean reductions of the long-term (2–5 days) concentrations of 29%–37% for indoor PM2.5 and endotoxin. A less significant reduction (19%–26%) was seen for Pb (Lead). © 2016 American Association for Aerosol Research
Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings
Creators: name: Yurttaş, Leyla
name: Özkay, Yusuf
name: Duran, Murat
name: Turan-Zitouni, Gülhan
name: Özdemir, Ahmet
name: Cantürk, Zerrin
name: Küçükoğlu, Kaan
name: Kaplancıklı, Zafer Asım
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) derivatives was undertaken starting from the potassium salt of 4-(2-pyrimidinyl)piperazine dithiocarbamate. The structures of the obtained compounds were elucidated by 1H NMR, 13C NMR, MS spectral data, and elemental analysis. The antimicrobial activity of the thirty eight newly synthesized compounds were tested against 12 microorganism strains using the microdilution technique. Compounds 2-(4-ethoxycarbonylthiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B12), 2-(3-fluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A18) and 2-(3,4-difluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A21) were determined to possess high antimicrobial activity.
Umso mehr kommt es auf die Lehrpersonen an: Defizitperspektiven von Lehrkräften an Schulen in sozialräumlich benachteiligten Lagen
Creators: name: Bremm, Nina
Publisher: name: Zenodo
Year: 2020
Subjects: Schule
Sozialräumliche Segregation
Lehrkräfteprofessionalisierung
Schulentwicklung
Defizitorientierung
Schüler-Lehrer-Beziehung

description: Dieser Beitrag geht der Frage nach, wie sich Orientierungen und Beziehungen von Lehrkräften zu benachteiligten Schüler*innen an sozialräumlich segregierten Schulen in Deutschland darstellen. Hierzu wurden im Rahmen des Projekts ‚Potenziale entwickeln – Schulen stärken‘ Daten von ca. 1.100 Lehrkräften an Schulen in benachteiligten Lagen im Ruhrgebiet erhoben. Eingesetzt wurde u.a. eine neu entwickelte Skala, die Orientierungen und Einschätzungen von Lehrkräften zur Leistungsfähigkeit von sozial benachteiligten Schüler*innen abbildet. Im Beitrag werden die Befunde theoretisch gerahmt und dargestellt und mit Blick auf spezifische Herausforderungen für die Schule und Unterrichtsentwicklung sowie die Lehrkräfteprofessionalisierung an Schulen in sozial segregierten Lagen diskutiert.
description: +repphzhbib2020W
Experiences of LGBTQ+ graduate students in research-focused doctoral programs: a scoping review
Creators: name: Baldwin-SoRelle, Carrie
name: McDonald, David A.
Publisher: name: Frontiers
Year: 2024

description: Students of sexual and gender minority (SGM) identities have long been underserved in higher education, and the limited research thus far has focused on undergraduates. There is a large gap in understanding the outcomes and experiences of LGBTQ+ graduate students, particularly in STEM. We undertook the first scoping review to examine the available literature on LGBTQ+ student experiences in research-focused doctoral programs. A scoping review methodology was utilized to compile a broad set of publications for a narrative review of emergent themes. A comprehensive search of 5 bibliographic databases yielded 1,971 unique studies, which were screened by two independent reviewers for data on LGBTQ+ doctoral students in non-clinical fields. Eighty-two publications were included in the analysis, over half of which were published in the past 5 years. Thirteen themes emerged from analyzing the included publications. LGBTQ+ ientities can continue evolving during graduate school, and some students incorporated SGM identities in their research (“mesearch”). Though students expected academia to be welcoming, many encountered repeated anti-LGBTQ+ bias that impacted their perceived safety for coming out. Nearly half of the studies mentioned intersectionality with other marginalized identities, including race/ethnicity, religion, disability, and others. Based on the information presented, we outline recommendations for practitioners to improve doctoral education, such as preparing teaching assistants to manage discriminatory classroom conduct.
Additional file 10 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 10: Figure S4. Maximum Likelihood tree of chelatase sequences. The scale bar indicates the average number of amino acid substitutions per site. The anchor sequences and methods are in Materials and methods.
Complete genome sequence of Sagittula stellata strain E-37 reveals a plasmid-encoded type six secretion system.
Creators: name: Gloria, Paul Christian T
name: Santos, Mary Nia M
name: Septer, Alecia N
name: Salazar, John Raymond B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: We announce the complete genome sequence of Sagittula stellata strain E-37. The hybrid assembly of long and short reads revealed one chromosome and four plasmids. Furthermore, the genome analysis showed that the plasmid-encoded type six secretion system is linked to plasmid replication genes that may be common to Roseobacters.
Synthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes
Creators: name: Işıklan, Muhammet
name: Sayın, Levent
name: Sonkaya, Ömer
name: Hökelek, Tuncer
name: Türk, Mustafa
name: Oğuztüzün, Serpil
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Octachlorocyclotetraphosphazene, N4P4Cl8, (1) was reacted with N, N′-dibenzylethylenediamine to synthesize partially substituted monospiro- (2), dispiro- (5) and tetraspirocyclotetraphosphazene (8) derivatives. The reactions of 2 and 5 with excess pyrrolidine and morpholine produced fully substituted pyrrolidino (3 and 6) and morpholino (4 and 7) spirocyclotetraphosphazenes. The structures of the compounds were determined with 1D (1H, 13C, 31P, and DEPT) NMR, 2D (HSQC) NMR, ESI-MS, FTIR, and elemental analysis. The solid-state structures of 6 and 7 were examined by X-ray crystallography. In 7, intramolecular C-H…O hydrogen bonds link the molecules into centrosymmetric dimmers. The cytotoxic activity of all the compounds against human cervix carcinoma cell lines (HeLa) was investigated. The study showed that these compounds exert limited cytotoxic, apoptotic and necrotic effects on HeLa cancer cell lines.
Additional file 2 of Multiomic approaches reveal novel lineage-specific effectors in the potato and tomato early blight pathogen Alternaria solani
Creators: name: Wang, Jinhui
name: Xiao, Siyu
name: Zheng, Lijia
name: Pan, Yang
name: Zhao, Dongmei
name: Zhang, Dai
name: Li, Qian
name: Zhu, Jiehua
name: Yang, Zhihui
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2. Figure S1. Schematic diagram of long-range synteny between genomes of strains NL03003 and HWC168. Figure S2. Multiple sequence alignment of AsCEP20 and its homologs. Figure S3. Transient expression of AsCEP19 and AsCEP20 in Nicotiana benthamiana leaves. Figure S4. PCR validation of the gene pair (AsCEP19 and AsCEP20) knockout mutant of Alternaria solani HWC168.
Trends and Associations in Hospitalizations Due to Corneal Ulcers in the United States, 2002–2012
Creators: name: Lee, Rachel
name: Manche, Edward E.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Purpose: To estimate incidence, temporal trends, and factors associated with inpatient hospitalization due to corneal ulcers in the United States. Methods: Data on inpatient hospitalizations due to corneal ulcers between 2002 and 2012 were reviewed using the National Inpatient Sample. A literature review was conducted to identify the most common causes of corneal ulcers, and use of contact lenses. Results: An estimated 19,878 patients were seen in US emergency departments for evaluation of corneal ulcers in 2012. Rates of inpatient hospitalization due to corneal ulcers remained comparable over the decade (2003: 4.9, 95% confidence interval, CI, 3.0–6.7; 2012: 2.7, 95% CI 2.2–3.3 patients per million US population). Among those hospitalized for ophthalmic disease, patients holding public or no insurance (odds ratio, OR, 1.8 and 2.5, respectively, p<0.001), from low-income neighborhoods (OR 1.6, p < 0.001), and of older age (OR 3.4, p < 0.001) were more likely to be hospitalized for corneal ulceration. Medical conditions associated with hospitalization for corneal ulcer included history of keratitis (7.7%, p < 0.001), HIV infection (2.6%, p = 0.003), history of contact lens-related complications (2.5%, p < 0.001), and history of eye injury (2.5%, p = 0.001). Patients with a history of keratitis (p = 0.006) or rheumatoid arthritis (p = 0.001) were each twice as likely to receive a corneal transplant. Conclusions: Factors associated with hospitalization for corneal ulcer include insurance status in addition to history of contact lens-related disease and keratitis. Efforts should be made to address these factors prior to development of severe ulcers.
Physical Activity and Symmetry Following Total Knee Arthroplasty: Results of a Pilot Randomized Trial
Creators: name: Queen, Robin M.
name: Schwartz, Todd A.
name: Allen, Kelli D.
name: Hales, Derek
name: Arbeeva, Liubov
name: Bracey, Daniel N.
name: Hill, Carla
name: Huffman, Katie F.
Publisher: name: Elsevier
Year: 2024

description: Objective This pilot trial examined a Physical Activity and Symmetry (PAS) intervention focused on common deficits of physical inactivity and joint loading asymmetry following total knee arthroplasty (TKA). Design Participants (n=60) were enrolled during routine physical therapy (PT) following TKA and randomized to the PAS intervention or an attention (ATT) control group. The PAS intervention included physical activity counseling and balance exercise to address joint loading symmetry; content was delivered during 2 sessions at the end of routine PT plus supplemental sessions 4-weeks and 8-weeks following PT. The ATT control condition included supplemental sessions at 4-weeks and 8-weeks focused on general evaluation of surgical recovery benchmarks. Primary outcomes were weekly minutes of moderate to vigorous physical activity (MVPA), measured with an accelerometer, and peak force loading symmetry (limb symmetry index; LSI) during a 10m walk, measured with a 3-sensor in-shoe device. General linear mixed models compared changes in outcomes between randomized groups at 3-month and 6-month follow-up. Results Both PAS and ATT groups increased MVPA, but there were no clinically meaningful between-group differences at 3- or 6-month follow-up (p>0.05). There were also no clinically meaningful between-group differences LSI at 3- or 6-month follow-up (p>0.05). Conclusion The PAS intervention did not yield improvements beyond ATT control. It is possible that PAS components were being delivered as part of routine PT, and a more intensive intervention (e.g., more visits, guidance for exercise progression) or targeted approach (e.g., those with deficits at end of routine care) may be needed to further improve outcomes.
Additional file 13 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 13: Figure S7. Maximum Likelihood tree of SOD sequences. The scale bar indicates the average number of amino acid substitutions per site. The anchor sequences and methods are in Materials and methods.
Understanding healthcare burden and treatment patterns among young adults with schizophrenia
Creators: name: Huang, Ahong
name: Amos, Tony B.
name: Joshi, Kruti
name: Wang, Li
name: Nash, Abigail
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Medicine
Science Policy
Mental Health

description: Background: Schizophrenia is a serious public health problem that affects ∼1% of the US population. Aims: To examine treatment patterns and evaluate healthcare resource utilization (HRU) and costs among young adults (18–35 years) with schizophrenia who were early in the disease. Materials and methods: Patients aged 18–64 years with ≥2 schizophrenia diagnoses in the identification period (January 1, 2012–September 30, 2015) and continuous enrollment for ≥12 months pre- and post-index date were identified from the OptumInsight Clinformatics DataMart. Demographics, clinical characteristics, HRU, costs, and treatment patterns were compared between schizophrenia and non-schizophrenia “controls” cohorts and between young (18–35 years) and older adults (36–64 years) with schizophrenia. Results: Among 9,889 schizophrenia patients, 23.70% were young adults (aged 18–35), had higher all-cause per-patient-per-year (PPPY) costs ($22,338 vs $7,332; p < .0001), higher inpatient costs ($8,857 vs $1,289; p < .0001), and longer inpatient length-of-stay (LOS) (5.0 vs 0.4 days, p < .0001; adjusted incidence rate ratio [aIRR] = 12.8; 95% confidence interval [CI] = 11.5–14.3) than controls. Among young adults with schizophrenia, there were more mental-health-related and fewer non-mental-health-related diagnoses compared to older adults with schizophrenia; 63.40% were male. Young adults with schizophrenia incurred higher inpatient costs ($15,692 vs $10,274; p < .0001) and longer inpatient LOS (9.6 vs 5.9 days, p < .0001; aIRR = 1.6; 95% CI = 1.4–1.8) compared to older adults with schizophrenia. A substantial proportion of patients were treated with oral antipsychotics vs long-acting injectables in both cohorts (young adults: 98.72% vs 9.71%; older adults: 98.10% vs 13.31%). Limitations: Claims data are collected for payment and not research. The presence of a prescription claim does not indicate medication was consumed or taken as prescribed. Conclusions: The economic burden for schizophrenia patients is substantial, especially among young adults. Based on this analysis, further research is warranted to better understand the association between adherent treatment patterns earlier in the disease and long-term health outcomes among patients with schizophrenia.
Dänische L2-Aussprache von Lernern mit Deutsch als Ausgangssprache : Fehler und Fehlerschwere
Creators: name: Tulaja, Lisa
Publisher: name: Christian-Albrechts-Universität zu Kiel
Year: 2019
Subjects: subject: Aussprachefehler; Fehlerschwere; Dänisch als Fremdsprache; error gravity; L2 pronunciation assessment; acceptability
subject: 948 Scandinavia

SeriesInformation
Understanding healthcare burden and treatment patterns among young adults with schizophrenia
Creators: name: Huang, Ahong
name: Amos, Tony B
name: Joshi, Kruti
name: Wang, Li
name: Nash, Abigail
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Medicine
Science Policy
Mental Health

description: Background: Schizophrenia is a serious public health problem that affects ∼1% of the US population. Aims: To examine treatment patterns and evaluate healthcare resource utilization and costs among young adults (18-35 years) with schizophrenia who were early in the disease. Materials and Methods: Patients aged 18-64 years with ≥2 schizophrenia diagnoses in the identification period (01JAN2012-30SEPT2015) and continuous enrollment for ≥12 months pre- and post-index date were identified from the OptumInsight Clinformatics DataMart. Demographics, clinical characteristics, HRU, costs, and treatment patterns were compared between schizophrenia and non-schizophrenia “controls” cohorts and between young (18-35 years) and older adults (36-64 years) with schizophrenia. Results: Among 9,889 schizophrenia patients, 23.70% were young adults (aged 18-35), had higher all-cause per-patient-per-year (PPPY) costs ($22,338 vs $7,332; p < 0.0001), higher inpatient costs ($8,857 vs $1,289; p < 0.0001) and longer inpatient length-of-stay (LOS) (5.0 vs 0.4 days, p < 0.0001; adjusted incidence rate ratio [aIRR]: 12.8; 95% confidence interval [CI]: 11.5-14.3) than controls. Among young adults with schizophrenia, there were more mental health-related and fewer non-mental health-related diagnoses compared to older adults with schizophrenia; 63.40% were male. Young adults with schizophrenia incurred higher inpatient costs ($15,692 vs $10,274; p < 0.0001) and longer inpatient LOS (9.6 vs 5.9 days, p < 0.0001; aIRR: 1.6; 95% CI: 1.4-1.8) compared to older adults with schizophrenia. A substantial proportion of patients were treated with oral antipsychotics vs long-acting in both cohorts (young adults: 98.72% vs 9.71%; older adults: 98.10% vs 13.31%). Limitations: Claims data are collected for payment and not research. Presence of a prescription claim does not indicate medication was consumed or taken as prescribed. Conclusions: The economic burden for schizophrenia patients is substantial, especially among young adults. Based on this analysis, further research is warranted to better understand the association between adherent treatment patterns earlier in the disease and long-term health outcomes among patients with schizophrenia.
Safety effectiveness and crash cost benefit of red light cameras in Missouri
Creators: name: Claros, Boris
name: Sun, Carlos
name: Edara, Praveen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Objective: Red light cameras (RLCs) have generated heated discussions over issues of safety effectiveness, revenue generation, and procedural due process. This study focuses on the safety evaluation of RLCs in Missouri, including the economic valuation of safety benefits. The publication of the national Highway Safety Manual (HSM; American Association of State Highway and Transportation Officials) in 2010 produced statistical safety models for intersections and spurred the calibration of these models to local conditions. Methods: This study adds to existing knowledge by applying the latest statistical methodology presented in the HSM and more current data. Driver behavior constantly changes due in part to driving conditions and the use of technology. The safety and economic benefit evaluation was performed using the empirical Bayes method, which accounts for regression to the mean bias. For the economic benefit evaluation, the KABCO crash severity scale and crash cost estimates were used. A total of 24 4-leg urban intersections were randomly selected from a master list of RLCs in Missouri from 2006 to 2011. Additionally, 35 comparable nontreated intersections were selected for the analysis. Results and Conclusions: The implementation of RLCs reduced overall angle crashes by 11.6%, whereas rear-end crashes increased by 16.5%. The net economic crash cost benefit of the implementation of RLCs was $35,269 per site per year in 2001 dollars (approximately $47,000 in 2015 dollars). Thus, RLCs produced a sizable net positive safety benefit that is consistent with previous statistical studies.
DAB2IP Loss in Luminal A Breast Cancer Leads to NF-kB Associated Aggressive Oncogenic Phenotypes
Creators: name: Van Alsten, Sarah C.
name: Hollern, Daniel P.
name: Spanheimer, Philip M.
name: Laws, Tyler
name: Kakati, Rasha T.
name: Troester, Melissa A.
name: Ebbs, Aaron L.
name: Baldwin, Albert S.
name: Mukherjee, Angana
name: Simon, Jeremy M.
name: Hoadley, Katherine A.
Publisher: name: American Society for Clinical Investigation
Year: 2024

description: Despite proven therapy options for estrogen receptor (ER)-positive breast tumors, a substantial number of ER+ cancer patients exhibit relapse with associated metastasis. Loss of expression of RasGAPs leads to poor outcomes in several cancers, including breast cancer. Mining the TCGA breast cancer RNA-sequencing dataset revealed that low expression of the RasGAP DAB2IP was associated with a significant decrease in relapse-free survival in Luminal A breast cancer patients. Immunostaining demonstrated that DAB2IP loss occurred in grade 2 tumors and higher. Consistent with this, genes upregulated in DAB2IP-low Luminal A tumors were shared with more aggressive tumor subtypes and were associated with proliferation, metastasis, and altered ER signaling. Low DAB2IP expression in ER+ breast cancer cells was associated with increased proliferation, enhanced stemness phenotypes, and activation of IKK, the upstream regulator of the transcription factor NF-kB. Integrating cell-based ChIP-sequencing with motif analysis and TCGA RNA-seq data, we identified a set of candidate NF-kB target genes upregulated with loss of DAB2IP linked with several oncogenic phenotypes, including altered RNA processing. This study provides insight into mechanisms associated with aggressiveness and recurrence within a subset of the typically less aggressive Luminal A breast cancer intrinsic subtype.