title: ÐÐ¼Ð¼ÑÐ½Ð¾ÑÐ¸ÑÐ¾Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ°Ñ Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÐºÐ¸ÑÑÐ¿ÐµÐ¿ÑÐ¸Ð½Ð¾Ð² Ð² ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð² Ð½Ð¾ÑÐ¼Ðµ Ð¸ Ð¿ÑÐ¸ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð¾Ð·Ðµ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ»ÐµÐ¹Ð¼ÐµÐ½Ð¾Ð²Ð°, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐµÐ»ÐºÐ¸
ÐºÐ¸ÑÑÐ¿ÐµÐ¿ÑÐ¸Ð½
ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð¾Ð·
Ð±ÐµÑÐ¿Ð»Ð¾Ð´Ð¸Ðµ
Ð¼Ð°ÑÑÐ¸ÐºÑÐ½ÑÐµ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð·Ñ
kisspeptin
endometriosis
sterility
matrix metallopoteinases

description: Ð¦ÐµÐ»ÑÑ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð±ÐµÐ»ÐºÐ° ÐºÐ¸ÑÑÐ¿ÐµÐ¿ÑÐ¸Ð½Ð° (KISS1) Ð¸ ÐµÐ³Ð¾ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ° (KISS1R) Ð¿ÑÐ¸ Ð½Ð°ÑÑÐ¶Ð½Ð¾Ð¼ Ð³ÐµÐ½Ð¸ÑÐ°Ð»ÑÐ½Ð¾Ð¼ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð¾Ð·Ðµ (ÐÐÐ­) Ð² ÑÐºÐ°Ð½Ð¸ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ñ, ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð³ÐµÑÐµÑÐ¾ÑÐ¾Ð¿Ð¸ÑÑ Ð¸ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ ÐºÑÐ»ÑÑÑÑÐ°Ñ. ÐÐ½Ð°Ð»Ð¸Ð· Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ, ÑÑÐ¾ Ð¾Ð±Ð° Ð±ÐµÐ»ÐºÐ° KISS1 Ð¸ KISS1R Ð¿ÑÐ¸ÑÑÑÑÑÐ²ÑÑÑ Ð² Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÑ ÑÐºÐ°Ð½ÑÑ Ð¸ ÐºÑÐ»ÑÑÑÑÐ°Ñ. Ð£ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾, ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ KISS1/KISS1R Ð² ÑÐºÐ°Ð½Ð¸ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ñ, Ð²Ð·ÑÑÐ¾Ð³Ð¾ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐºÐ¸ Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾Ð·Ð¾Ð¼ ÐÐÐ­, ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ ÑÐ½Ð¸Ð¶ÐµÐ½, Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð³ÑÑÐ¿Ð¿Ð¾Ð¹ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾ ÑÐ°Ðº Ð¶Ðµ, ÑÑÐ¾ KISS1/KISS1R Ð¿ÑÐ¸ÑÑÑÑÑÐ²ÑÐµÑ Ð² ÑÐºÐ°Ð½Ð¸ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð³ÐµÑÐµÑÐ¾ÑÐ¾Ð¿Ð¸Ð¸. Ð£ÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ KISS1/KISS1R Ð±ÑÐ» ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸ Ð½Ð¸Ð¶Ðµ, ÑÐµÐ¼ Ð² ÐºÐ¾Ð½ÑÑÐ¾Ð»Ðµ. KISS1 Ð±ÑÐ» Ð¾Ð¿Ð¸ÑÐ°Ð½ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÐµÐ³ÑÐ»ÑÑÐ¾ÑÐ° Ð¼Ð°ÑÑÐ¸ÐºÐ½ÑÑ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð· (ÐÐÐ), Ð¾Ð½ ÑÐ¿Ð¾ÑÐ¾Ð±ÐµÐ½ Ð¿Ð¾Ð´Ð°Ð²Ð»ÑÑÑ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð². Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð¼Ð¾Ð¶Ð½Ð¾ Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÑ, ÑÑÐ¾ ÐÐÐ Ð¿ÑÐ¸ ÐÐÐ­ ÑÑÐ¿ÑÐµÑÑÐ¸ÑÑÑÑÑÑ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾, Ð° ÑÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸ÑÑ Ðº Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¼Ð¸Ð³ÑÐ°ÑÐ¸Ð¸ (Ð¸Ð½Ð²Ð°Ð·Ð¸Ð¸ ÐºÐ»ÐµÑÐ¾Ðº) Ð¸ Ðº Ð°Ð³ÑÐµÑÑÐ¸Ð²Ð½Ð¾Ð¼Ñ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð¾Ð·Ð°. ÐÐ¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾, Ð² Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ¼ ÑÐ¸ÑÑÐµÐ¼Ñ KISS1/KISS1R Ð¼Ð¾Ð¶Ð½Ð¾ Ð±ÑÐ´ÐµÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÐ³Ð½ÐµÑÐ°ÑÑÐµÐ³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð´Ð»Ñ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ MMÐ, Ð¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÑÐµÐ¼ ÑÐ°Ð¼ÑÐ¼ ÑÑÐ»Ð¾Ð²Ð¸Ð¹, Ð¿ÑÐ¸ ÐºÐ¾ÑÐ¾ÑÑÑ Ð¸Ð½Ð²Ð°Ð·Ð¸Ñ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº Ð±ÑÐ´ÐµÑ Ð·Ð°ÑÑÑÐ´Ð½ÐµÐ½Ð°. Ð Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¾ÑÑÐ°Ð±Ð¾ÑÐ°Ð½ ÑÐµÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ ÑÐ½Ð´Ð¾Ð¼ÐµÑÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¹ ÐºÑÐ»ÑÑÑÑÑ Ð¾Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ðº Ñ ÐÐÐ­ Ð¸ Ð¾Ñ Ð·Ð´Ð¾ÑÐ¾Ð²Ð¾Ð¹ Ð¶ÐµÐ½ÑÐ¸Ð½Ñ. ÐÐ¼Ð¼ÑÐ½Ð¾ÑÐ»ÑÐ¾ÑÐµÐ½ÑÐµÐ½ÑÐ½ÑÐ¼ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð² ÐºÑÐ»ÑÑÑÑÐ°Ñ Ð¿ÑÐ¸ÑÑÑÑÑÐ²ÑÑÑ Ð±ÐµÐ»ÐºÐ¸ KISS1 Ð¸ KISS1R.
description: We consider the kisspeptin (KISS1) and kisspeptins receptor (KISS1R) for endometriosis genitals externa (EGE) in endometrial tissue, endometrial heterotopy and cell cultures. Immunohistochemical study of endometrium and endometriosis heterotopia define KISS1/KISS1R expression was detected in EGE and control, but to different degrees. Expression level KISS1/KISS1R in endometrial tissue taken from a patient diagnosed with EGE, compared to the control group (p&lt;0,05). KISS1/KISS1R present in the tissue endometrial heterotopy. The expression level KISS1/KISS1R was lower than the control (p&lt;0,05). Kisspeptins have been described as regulators of matrix metalloproteinases (MMPs) at both the transcriptional of proteins. So we can assume that MMP are suppressed less and this leads to the migration of the active (invasion of cells). The study perfected the fermentation method for the preparation endometrial cell culture from patients with EGE and from healthy women. Immunofluorescence method was shown to be present in cultures and KISS1 KISS1R proteins.