cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adhesion structures in leukemia cells and their regulation by Src family kinases
Creators: name: Röselová, Pavla
name: Obr, Adam
name: Aleš Holoubek
name: Grebeňová, Dana
name: Kateřina Kuželová
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling pathways have been extensively studied in adherent cells as well as in mature haematopoietic cells, but the adhesion structures and signaling in haematopoietic stem and progenitor cells, either normal or malignant, are much less explored. We analyzed the interaction of leukemia cells with fibronectin (FN) using interference reflection microscopy, immunofluorescence, measurement of adherent cell fraction, real-time microimpedance measurement and live cell imaging. We found that leukemia cells form very dynamic adhesion structures similar to early stages of focal adhesions. In contrast to adherent cells, where Src family kinases (SFK) belong to important regulators of focal adhesion dynamics, we observed only minor effects of SFK inhibitor dasatinib on leukemia cell binding to FN. The relatively weak involvement of SFK in adhesion structure regulation might be associated with the lack of cytoskeletal mechanical tension in leukemia cells. On the other hand, active Lyn kinase was found to specifically localize to leukemia cell adhesion structures and a less firm cell attachment to FN was often associated with higher Lyn activity (this unexpectedly occurred also after cell treatment with the inhibitor SKI-1). Lyn thus may be important for signaling from integrin-associated complexes to other processes in leukemia cells.
title: saint Mercure
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Saint militaire de l'Église grecque, martyrisé sous Julien l'Apostat ; patron de l'abbaye bénédictine de Corvey ; attributs : une cuirasse, la lance au poing, l'empereur Julien l'Apostat aux pieds de son cheval.
The early pregnancy placenta foreshadows dna methylation alterations of solid tumors
Creators: name: Akpéli V. Nordor
name: Nehar-Belaid, Djamel
name: Richon, Sophie
name: Klatzmann, David
name: Bellet, Dominique
name: Dangles-Marie, Virginie
name: Fournier, Thierry
name: Aryee, Martin J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues, promote angiogenesis—while surviving hypoxia—, and escape the immune system. Similarities in DNA methylation patterns between the placenta and cancers suggest that common epigenetic mechanisms may be involved in regulating these behaviors. We show here that megabase-scale patterns of hypomethylation distinguish first from third trimester chorionic villi in the placenta, and that these patterns mirror those that distinguish many tumors from corresponding normal tissues. We confirmed these findings in villous cytotrophoblasts isolated from the placenta and identified a time window at the end of the first trimester, when these cells come into contact with maternal blood, as the likely time period for the methylome alterations. Furthermore, the large genomic regions affected by these patterns of hypomethylation encompass genes involved in pathways related to epithelial-mesenchymal transition, immune response, and inflammation. Analyses of expression profiles corresponding to genes in these hypomethylated regions in colon adenocarcinoma tumors point to networks of differentially expressed genes previously implicated in carcinogenesis and placentogenesis, where nuclear factor kappa B is a key hub. Taken together, our results suggest the existence of epigenetic switches involving large-scale changes of methylation in the placenta during pregnancy and in tumors during neoplastic transformation. The characterization of such epigenetic switches might lead to the identification of biomarkers and drug targets in oncology as well as in obstetrics and gynecology.
Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?
Creators: name: McCullough, Lauren E.
name: Erline E. Miller
name: Calderwood, Laura E.
name: Nitin Shivappa
name: Steck, Susan E.
name: Forman, Michele R.
name: Mendez, Michelle A.
name: Maguire, Rachel
name: Fuemmeler, Bernard F.
name: Kollins, Scott H.
name: Bilbo, Staci D.
name: Zhiqing Huang
name: Murtha, Amy P.
name: Murphy, Susan K.
name: Hébert, James R.
name: Hoyo, Cathrine
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Excessive inflammation during pregnancy alters homeostatic mechanisms of the developing fetus and has been linked to adverse pregnancy outcomes. An anti-inflammatory diet could be a promising avenue to combat the pro-inflammatory state of pregnancy, particularly in obese women, but we lack mechanistic data linking this dietary pattern during pregnancy to inflammation and birth outcomes. In an ethnically diverse cohort of 1057 mother-child pairs, we estimated the relationships between dietary inflammatory potential [measured via the energy-adjusted dietary inflammatory index (E-DII™)] and birth outcomes overall, as well as by offspring sex and maternal pre-pregnancy body mass index (BMI). In a subset of women, we also explored associations between E-DII, circulating cytokines (n = 105), and offspring methylation (n = 338) as potential modulators of these relationships using linear regression. Adjusted regression models revealed that women with pro-inflammatory diets had elevated rates of preterm birth among female offspring [β = −0.22, standard error (SE) = 0.07, P<0.01], but not male offspring (β=0.09, SE = 0.06, P<0.12) (Pinteraction = 0.003). Similarly, we observed pro-inflammatory diets were associated with higher rates of caesarean delivery among obese women (β = 0.17, SE = 0.08, P = 0.03), but not among women with BMI <25 kg/m2 (Pinteraction = 0.02). We observed consistent inverse associations between maternal inflammatory cytokine concentrations (IL-12, IL-17, IL-4, IL-6, and TNFα) and lower methylation at the MEG3 regulatory sequence (P<0.05); however, results did not support the link between maternal E-DII and circulating cytokines. We replicate work by others on the association between maternal inflammatory diet and adverse pregnancy outcomes and provide the first empirical evidence supporting the inverse association between circulating cytokine concentrations and offspring methylation.
A Green One-Pot Synthesis of New and Known 5-Oxatetracene Derivatives Using Carboxylated Multiwall Carbon Nanotubes
Creators: name: Khodabakhshi, Saeed
name: Mori, Bahareh Abdol Pour
name: Baghernejad, Mojtaba
name: Sajad Kiani
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: 5-oxatetracene derivatives including five fused rings have been synthesized by the use of carboxylated multiwall carbon nanotubes (CMWCNTs) as powerful nanocatalysts. The CMWCNTs showed a high efficiency under solvent-free conditions and a good recyclability. Catalyst loadings can be as low as 0.008 g to give corresponding products at 110°C. Using a standard catalyst, avoidance of toxic organic solvents, simple work-up procedure, short reaction times, and high yield of products are the major advantages of the present method.
Synthesis, structural and thermal characterizations and in vitro cytotoxic activities of new cyclotriphosphazene derivatives
Creators: name: Koran, Kenan
name: Çiğdem Tekin
name: Çalışkan, Eray
name: Tekin, Suat
name: Sandal, Süleyman
name: Görgülü, Ahmet Orhan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: We investigated the cytotoxic effects of the newly synthesized cyclotriphosphazene derivatives on A2780 (ovarian), PC-3 and LNCaP (prostate) cancer cell lines. 4′-hydroxy-substituted-chalcone compounds (2–8) were reacted with diphenyl-cyclotriphosphazene (DPP) in the presence of acetone/K2CO3 in order to obtain novel cyclotriphosphazene compounds (DPP 2–8). The structures of DPP 2–8 were characterized by MALDI-TOF mass spectrometry, FT-IR, elemental analysis, 1H, 13C-APT, and 31P NMR measurements. The thermal properties of all phosphazene compounds have been studied after synthesis and characterization procedure. The cytotoxic effects of DPP 2–8 were examined primarily by applying the MTT method based on the measurement of mitochondrial activity. In this regard, several phosphazene compounds have shown high chemotherapeutic effect at low dose (p < 0.05). When the cytotoxic effects of DPP 2–8 at doses of 1, 5, 25, 50 and 100 µM on A2780 cells were examined, it was observed that DPP-3, DPP-4, DPP-5 and DPP-7 were more effective than other derivatives suggested by their high Log IC50 values (p < 0.05). The compounds DPP 2–8 possess cytotoxic activity against PC-3 and LNCaP cells (especially compounds DPP-4 and DPP-5, p < 0.05).
New silica-based hybrid materials (Nouveaux matériaux hybrides à base de silicium)
Creators: name: Hellali, Taoufik
name: Hafidh, Afifa
name: Noureddine Etteyeb
name: Touati, Fathi
name: Hamzaoui, Ahmed Hichem
name: Somrani, Sayda
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry

description: New hybrid organic-inorganic materials have been obtained by reactions at room temperature of polymethylhydrosiloxane (PMHS) with different organic bi-functional molecules, in tetrahydrofuran (THF) using hexachloroplatinic acid (H2PtCl6.6H2O) as a catalyst. These reactions have led to the formation of monolithic colored and transparent polymeric gels. The characterization of xerogels has been carried by infrared, 29Si and 13C CP MAS NMR and thermal analysis DTA-TGA. Xerogels morphology and texture were studied by scanning electron microscopy (SEM) and Brunauer–Emmet–Teller method (BET). The obtained results show that organic molecules react with PMHS leading to gels in which Si–N and Si–O covalent bridges are formed. The optic and magnetic properties of hybrid gels are studied respectively by UV-Vis spectroscopy and RPE. The obtained results show that materials are paramagnetic semiconductors.
Occupant responses in conventional and ABTS seats in high-speed rear sled tests
Creators: name: Viano, David C.
name: Parenteau, Chantal S.
name: Burnett, Roger
name: Prasad, Priya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Neuroscience
Science Policy

description: Objective: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and all belts to seat (ABTS) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. Methods: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration. The 50th percentile Hybrid III was lap–shoulder belted in the FMVSS 208 design position. The testing included 11 <2000 MY, 8 ≥2000 MY, and 7 ABTS seats. The dummy was fully instrumented, including head accelerations, upper and lower neck 6-axis load cells, chest acceleration, thoracic and lumbar spine load cells, and pelvis accelerations. The peak responses were normalized by injury assessment reference values (IARVs) to assess injury risks. Statistical analysis was conducted using Student's t test. High-speed video documented occupant kinematics. Results: Biomechanical responses were lower with modern (≥2000 MY) seats than older (<2000 MY) designs. The lower neck extension moment was 32.5 ± 9.7% of IARV in modern seats compared to 62.8 ± 31.6% in older seats (P =.01). Overall, there was a 34% reduction in the comparable biomechanical responses with modern seats. Biomechanical responses were lower with modern seats than ABTS seats. The lower neck extension moment was 41.4 ± 7.8% with all MY ABTS seats compared to 32.5 ± 9.7% in modern seats (P =.07). Overall, the ABTS seats had 13% higher biomechanical responses than the modern seats. Conclusions: Modern (≥2000 MY) design seats have lower biomechanical responses in 40.2 km/h rear sled tests than older (<2000 MY) designs and ABTS designs. The improved performance is consistent with an increase in seat strength combined with improved occupant kinematics through pocketing of the occupant into the seatback, higher and more forward head restraint, and other design changes. The methods and data presented here provide a basis for standardized testing of seats. However, a complete understanding of seat safety requires consideration of out-of-position (OOP) occupants in high-speed impacts and consideration of the much more common, low-speed rear impacts.
Synthesis and characterization of halogenated bis(acylthiourea) derivatives and their antibacterial activities
Creators: name: Ainaa Nadiah Abd Halim
name: Ngaini, Zainab
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para positions. The structures of the synthesized compounds were confirmed by CHN elemental analysis, FT-IR, 1H NMR and 13C NMR spectroscopies. Antibacterial studies of the compounds via the Kirby Bauer disc diffusion method against Escherichia coli (E. coli) ATCC 25922 and Staphylococcus aureus (S. aureus) S48/81 demonstrated that bis(acylthiourea) N1,N4-bis[(2-chlorophenyl)carbamothioyl]terephthalamide (4) and N1,N4-bis[(2-bromophenyl)carbamothioyl]terephthalamide (7) bearing Cl and Br at the ortho position exhibited excellent activities against both bacteria strains compared to ampicillin standard.
Persistent organic pollutants in Pakistan: Potential threat to ecological integrities in terms of genotoxicity and oxidative stress
Creators: name: Mujtaba Baqar
name: Arslan, Muhammad
name: Yumna Sadef
name: Adeel Mahmood
name: Qadir, Abdul
name: Ahmad, Sajid Rashid
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: As a consequence of both increasing population and industrialization in agro-economic sector, Pakistan has inevitably been confronted by multicomplex environmental challenges. Owing in part to poor regulatory framework, pollution due to persistent organic pollutants (POPs) has caused serious problems throughout the country. Resultantly, extensive use of POPs is causing vigorous deterioration of environment and human health. The current study addresses: (1) the general information on associated ecological effects and toxicity assessment by meta-analysis for local fauna and flora (2) their respective occurrence in living organisms; and (3) sources and distribution patterns of various POPs classes in environmental compartments of Pakistan. Based on the study, it can be concluded that the environment of Pakistan is highly contaminated with organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dechlorane plus (DP), and polychlorinated naphthalenes (PCNs), which is further supported with the meta-analysis. Nevertheless, unavailability of environmental quality standards and food safety for POPs render it a forthcoming challenge of multicompartment toxicity exposure. Therefore, strategies must be planned for risk assessment of biologically active POPs, while the POP waste inventory should be elevated, along with the necessary measures to promote appropriate handling and treatment of POP as a matter of prime importance.
Ambiência pós-porteira: caracterização climática do transporte e da espera na avicultura industrial e severidade de arranhões originados durante a fase de pré-abate
Creators: name: Benincasa, Natália Cristina
name: Sakamoto, Karina Suemi
name: Silva, Iran José Oliveira Da
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences

description: O transporte de frangos de corte no Brasil possui características críticas a começar pelas condições dos caminhões utilizados, em que as aves ficam expostas. Outra etapa crítica no pré-abate é a espera no abatedouro, pois muitos locais não possuem sombreamento nem controle de temperatura e umidade. O objetivo deste estudo foi caracterizar o microclima das caixas que acondicionam os frangos durante o transporte e espera em frigorífico comercial e verificar a incidência e a severidade de arranhões oriundos especificamente da fase de pré-abate. Instalou-se termo-higrômetros em 80 caixas de transporte em 8 carregamentos entre as granjas e o frigorífico. Após a espera avaliou-se arranhões em 80 aves por meio de escores (Escore A: nenhuma evidência de arranhão superficial ou profundo sobre a pele da região ventral, dorsal, das pernas ou sambiqueira; Escore B: pelo menos 1 ou até 2 arranhões superficiais sobre as mesmas regiões e Escore C: 1 arranhão profundo ou presença de pelo menos 3 arranhões superficiais). O Escore A constatou animais sem arranhões, o B arranhões leves e o Escore C arranhões considerados severos. Verificou-se que 50% dos transportes apresentaram temperatura (T) superior à ideal preconizada pela literatura, 87,5% dos carregamentos apresentaram-se com umidade relativa do ar (UR) acima do limite de conforto e apesar desses resultados, apenas 37,5% dos carregamentos apresentaram faixas de entalpia (H) acima do limite de conforto. Os resultados da espera revelaram um estado mais crítico, visto que embora 25% dos carregamentos apresentaram T superiores às recomendadas, 100% dos carregamentos apresentaram UR e H acima da faixa de conforto preconizada, de modo que pôde ser percebido um aumento médio de 2,5% na T e 11,1% na UR e H quando comparado com o transporte. Dos animais avaliados, em média 76,3% não apresentaram arranhões recentes, enquanto que 14,8% apresentaram arranhões considerados leves e 9,20% das aves apresentaram arranhões graves. A maioria dos transportes apresentou condições adequadas de conforto térmico, o que pode ser devido aos mesmos terem sido realizados no período mais fresco do dia e que a espera apresentou condições climáticas mais críticas, que possivelmente se deve ao molhamento dos animais à chegada ao abatedouro, prejudicando as trocas de calor devido à alta umidade e temperatura dentro das caixas. Foi observada alta incidência de arranhões leves e graves e as suas causas precisam ser melhor estudadas e minimizadas.
Potential risk of thermal stress for Bradford bulls in Brazilian tropical and subtropical regions
Creators: name: Menegassi, Silvio Renato Oliveira
name: Berlitz, Carolina Gabriela Becker
name: Rocha, Marcela Kuczynski Da
name: Pereira, Gabriel Ribas
name: Koetz, Celso
name: Barcellos, Júlio Otávio Jardim
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences

description: Thermal stress imparts physical and economical losses to livestock production in temperate, subtropical and tropical regions of the world. The Temperature and Humidity Index (THI) was brought as an option to evaluate the morphological changes from bull semen according to environmental stress. The objective of this work was to evaluate the reproductive performance in Braford bulls, through the seminal quality, using THI as an environmental stress in the tropical and subtropical regions in Brazilian. We used Braford bulls from 5 different experiments, three farms located at the subtropical Brazilian region and two at the tropical. Semen collections were performed at least once a month through the experimental periods. Climate data was analysed 18 and 12 days prior to sampling corresponding to the spermiogenesis and the epidydimal transit period. The data was analysed through ANOVA, means differentiated through Tukey test and p-value was set at >0.05. The subtropical and tropical region presented significant differences within the area studied and specially when suggesting a climate zoning for animal production. The percentage of days categorized as harmful was significant for both regions and its correlated to the total and major sperm defects, representing the importance of environmental changes as a stressor to sperm. Both regions showed a significant variation between seasons that classified the summer and the hot humid period as more stressful impact on the animal growth and well-being. The Braford genetic, being a mixed of Bos taurus indicus and Bos taurus taurus, would be a potential breed to be adapted to the tropics, however a quantification of weather effect is difficult to achieve accuracy on the acclimatization process, variance between individuals, different farm management and changes in the combination of environmental factors.
Procedures for measuring 3-D surface area and surface temperature of livestock
Creators: name: Milan, Hugo FM
name: Perano, Kristen M
name: Kifle G Gebremedhin
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences

description: Bio-energetic models of livestock require geometrical properties (e.g., surface area) of animals. Currently, the surface area of animals is estimated from empirical equations based on body weight or assuming the animal as cylinders or spheres. These approximations do not accurately characterize the true geometry of the animal. Similarly, skin-surface temperature predictions from bio-energetic models are validated by taking spot measurements, which neglects the spatial variability of this parameter. In this study, an accurate approach of measuring these parameters is proposed. Based on preliminary results (more data analysis is ongoing), the advantages and disadvantages of various 3-D scanning technologies (photogrammetry, Kinect V1, Kinect V2, Intel® RealSense™ SR300, and Intel® RealSense™ R200) as well as two different procedures for obtaining 3-D surface temperature (thermal projection and thermal photogrammetry) are discussed. Kinect (V1 or V2) is recommended for 3-D scanning of livestock because the sensors are cheap and easy to use. Sense from 3-D Systems (Intel® RealSense™ SR300) does not support large scanning volumes but it is recommended for scanning small animals (or parts of an animal) because it is handheld and the software is easy to use. To scan large animals (e.g., a whole cow) and for advanced users, Intel® RealSense™ R200 is suitable. For 3-D surface temperature, thermal photogrammetry is recommended because it is less error prone than thermal projection.
Electronic supplementary material from Comparability of comparative toxicity: insect sensitivity to imidacloprid reveals huge variations across species but also within species
Creators: name: Nagloo, Nicolas
name: Rigosi, Elisa
name: Herbertsson, Lina
name: O'Carroll, David Charles
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified

description: The supplementary materials include supplementary figures and the list of articles present in the dataset.
title: sainte Claire
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Abbesse, disciple de saint François d'Assise, fondatrice l'ordre des pauvres dames (les clarisses), en 1212 ; le pape innocent IV la fit canoniser en 1255 : représentée en nonne franciscaine avec une cordelière à trois nœuds et un manteau à raies transversales ; attributs : la monstrance, une croix surmontée d'un rameau d'olivier ; parfois elle tient une branche de lis et une lampe d'argile antique.
title: Qu'est-ce qu'un bon lycée ? Questions de mesure ( LIEPP Policy Brief, n°54)
Creators: name: Givord, Pauline
Publisher: name: Sciences Po - LIEPP
Year: 2021
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Mesurer la capacité d’un établissement scolaire à faire progresser les élèves qu’il scolarise est un exercice compliqué. Les taux de réussite au baccalauréat n’informent que peu sur, par exemple, la capacité d’un lycée à accompagner l’ensemble de leurs élèves, à leur permettre de construire un projet d’orientation et à leur donner les moyens d’y parvenir. Surtout, les résultats d’un lycée sont en très grande partie liés au niveau initial des élèves : des taux de réussite élevés peuvent traduire le degré de sélectivité du recrutement plus que la qualité du suivi des élèves. Enfin, des indicateurs sur les taux de réussite moyen d’un établissement ne renseignent qu’imparfaitement sur la réussite de l’ensemble de ses élèves. Une étude menée à partir des résultats au baccalauréat 201 5 montre ainsi que, en tenant compte de la composition sociale et scolaire des établissements, certains lycées tendent à amplifier les écarts de niveau scolaire entre les élèves qu’ils scolarisent, tandis que d'autres parviennent à réduire les écarts de réussite, sans sacrifier le niveau moyen.
description: Measuring how a school is effective in improving students' learning is a difficult task. For example, the success rates at an exam tell us little about a school's ability to support all of its students, to assist them in identifying their educational and career aspirations and to give them the means to achieve them. A school success rate is mostly explained by the initial level of students: high success rates of a school may reflect its selectivity in enrollment more than its ability to make students improve their performance. In addition, an average success rate indicator provides only partial information about the effect on the learning improvement of every student of a school. A study based on the results of the French 2015 baccalaureate shows that, taking into account the social and academic composition of schools, some highschools tend to increase the gaps in academic level between the students they enroll, while others manage to reduce the gaps in performance between students without downgrading the average level.
Persistent organic pollutants in Pakistan: potential threat to ecological integrities in terms of genotoxicity and oxidative stress
Creators: name: Mujtaba Baqar
name: Arslan, Muhammad
name: Yumna Sadef
name: Adeel Mahmood
name: Qadir, Abdul
name: Ahmad, Sajid Rashid
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: As a consequence of both increasing population and industrialization in agro-economic sector, Pakistan has inevitably been confronted by multicomplex environmental challenges. Owing in part to poor regulatory framework, pollution due to persistent organic pollutants (POPs) has caused serious problems throughout the country. Resultantly, extensive use of POPs is causing vigorous deterioration of environment and human health. The current study addresses: (1) the general information on associated ecological effects and toxicity assessment by meta-analysis for local fauna and flora (2) their respective occurrence in living organisms; and (3) sources and distribution patterns of various POPs classes in environmental compartments of Pakistan. Based on the study, it can be concluded that the environment of Pakistan is highly contaminated with organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dechlorane plus (DP), and polychlorinated naphthalenes (PCNs), which is further supported with the meta-analysis. Nevertheless, unavailability of environmental quality standards and food safety for POPs render it a forthcoming challenge of multicompartment toxicity exposure. Therefore, strategies must be planned for risk assessment of biologically active POPs, while the POP waste inventory should be elevated, along with the necessary measures to promote appropriate handling and treatment of POP as a matter of prime importance.
Occupant Responses in Conventional and ABTS Seats in High-Speed Rear Sled Tests
Creators: name: Viano, David C.
name: Parenteau, Chantal S.
name: Burnett, Roger
name: Prasad, Priya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Neuroscience
Science Policy

description: Objective: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and ABTS (all belts to seat) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. Methods: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration. The 50th Hybrid III was lap-shoulder belted in the FMVSS 208 design position. The testing included 11 <2000 MY, 8 ≥2000 MY and 7 ABTS seats. The dummy was fully instrumented including head accelerations, upper and lower neck 6 axis load cells, chest acceleration, thoracic and lumbar spine load cells and pelvis accelerations. The peak responses were normalized by IARV to assess injury risks. Statistical analysis was conducted using the Student t-test. High-speed video documented occupant kinematics. Results: Biomechanical responses were lower with modern (≥2000 MY) seats than older (<2000 MY) designs. The lower-neck extension moment was 32.5% ± 9.7% of IARV in modern seats compared to 62.8% ± 31.6% in older seats (p = 0.01). Overall, there was a 34% reduction in the comparable biomechanical responses with the modern seats. Biomechanical responses were lower with modern seats than ABTS seats. The lower neck extension moment was 41.4% ± 7.8% with all MY ABTS seats compared to 32.5% ± 9.7% in modern seats (p = 0.07). Overall, the ABTS seats had 13% higher biomechanical responses than the modern seats. Conclusions: Modern (≥2000 MY) design seats have lower biomechanical responses in 40.2 km/h rear sled tests than older (<2000 MY) designs and ABTS designs. The improved performance is consistent with an increase in seat strength combined with improved occupant kinematics through pocketing of the occupant into the seatback, higher and more forward head restraint and other design changes. The methods and data presented here provide a basis for standardized testing of seats. However, a complete understanding of seat safety requires consideration of out of position occupants (OOP) in high-speed impacts and consideration of the much more common, low-speed rear impacts.
Iron loading in HFE p.C282Y homozygotes found by population screening: relationships to HLA-type and T-lymphocyte subsets
Creators: name: Thorstensen, Ketil
name: Kvitland, Mona A.
name: Irgens, Wenche Ø.
name: Åsberg, Arne
name: Borch-Iohnsen, Berit
name: Torolf Moen
name: Hveem, Kristian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Iron loading in p.C282Y homozygous HFE hemochromatosis subjects is highly variable, and it is unclear what factors cause this variability. Finding such factors could aid in predicting which patients are at highest risk and require closest follow-up. The degree of iron loading has previously been associated with certain HLA-types and with abnormally low CD8 + cell counts in peripheral blood. In 183 Norwegian, p.C282Y homozygotes (104 men, 79 women) originally found through population screening we determined HLA type and measured total T-lymphocytes, CD4 + and CD8 + cells, and compared this with data on iron loading. In p.C282Y homozygous men, but not in homozygous women, we found that the presence of two HLA-A*03 alleles increased the iron load on average by approximately 2-fold compared to p.C282Y homozygous men carrying zero or one A*03 allele. On the other hand, the presence of two HLA-A*01 alleles, in male subjects, apparently reduced the iron loading. In p.C282Y homozygous individuals, the iron loading was increased if the CD8 + cell number was below the 25 percentile or if the CD4 + cell number was above the 75 percentile. This effect appeared to be additive to the effect of the number of HLA-A*03 alleles. Our data indicate that homozygosity for the HLA-A*03 allele significantly increases the risk of excessive iron loading in Norwegian p.C282Y homozygous male patients. In addition, low CD8 + cell number or high CD4 + cell number further increases the risk of excessive iron loading.
Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome
Creators: name: Luotola, Kari
name: Piltonen, Terhi T.
name: Puurunen, Johanna
name: Morin-Papunen, Laure C.
name: Tapanainen, Juha S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Biology

description: Objective: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). Design and methods: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. Results: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p ≤ .042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p ≤ .025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone >1.2 nmol/l compared with lower levels at baseline (p = .043) and at six months (p = .003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p ≤ .046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone. Conclusions: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.
title: Vie du Pape Alexandre VI et de son fils César Borgia, avec les pièces originales, traduite de l’anglais d’Alexandre Gordon
Creators: name: Gordon, Alexander
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 2 vol. : fig. ; 12°
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Liber, Leberp-3163
Avaliação do microclima de pastagens em sistema silvipastoril
Creators: name: Zilmara Maria Welfer Czekoski
name: CôrreaVieira, Frederico Márcio
name: Maiane Cristina Rodrigues Dos Santos
name: Matheus Junior Zanus Lovatto
name: Olmar Antônio Denardin Costa
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences

description: Animais são vulneráveis aos elementos climáticos, com isso o sistema silvipastoril destaca-se, pois proporciona sombra para os animais e pastagens, bem como diminui a incidência de radiação solar sobre os mesmos. Objetivou-se com este trabalho avaliar o microclima oferecido por pastagens em sistema silvipastoril comparado com pastagem sem este sistema. Este estudo foi desenvolvido no setor de Ovinocultura da UTFPR, câmpus Dois Vizinhos/PR. As avaliações de microclima foram realizadas em sistema silvipastoril e a pleno sol, em cinco dias aleatórios, durante os meses de janeiro e fevereiro de 2017. Em ambos os tratamentos foram avaliadas as seguintes variáveis microclimáticas: temperatura e umidade relativa do ar, velocidade do vento, temperatura do ponto de orvalho e temperatura de globo negro. Após obteve-se os índices de temperatura e umidade (ITGU), e índice de conforto térmico (ICT), para avaliar se os animais encontravam-se dentro da faixa de conforto térmico. A temperatura do ar apresentou-se elevada no turno da tarde e no sistema pleno sol. A temperatura do globo negro apresentou-se diferente (P<0,05) entre manhã e tarde e entre os tratamentos. O ICT apresentou diferença estatística (P<0,05), entre os turnos do dia e entre os tratamentos e o ITGU diferiu (P<0,05) entre os turnos e tratamentos. O sistema silvipastoril influenciou o microclima reduzindo a temperatura do ar e temperatura do globo negro, promovendo conforto térmico aos animais submetidos a este tipo de ambiente.
Ambiência Pós-Porteira: Análise das principais condenações, em frangos de corte criados em galpões de pressão positiva e negativa
Creators: name: Sakamoto, Karina Suemi
name: Benincasa, Natália Cristina
name: Silva, Iran José Oliveira Da
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences

description: As condenações por problemas de qualidade das carcaças provocam enormes perdas no setor de produção avícola mundial. O objetivo deste trabalho foi analisar as principais condenações totais e parciais na inspeção post mortem em carcaças de frangos de corte criados em galpões de pressão positiva e negativa. A pesquisa foi realizada entre junho a setembro de 2016 em uma empresa comercial, onde foram estudados 4 lotes de frangos de corte (2 lotes de galpões de pressão positiva e 2 lotes de pressão negativa). De cada um dos lotes estudados foi registrado no abatedouro as condenações parciais e totais de acordo com o Serviço de Inspeção Federal (SIF) do Ministério da Agricultura Pecuária e Abastecimento (MAPA) referente a cada caminhão transportador estudado (n=4). Em cada caminhão foram transportadas 3888 aves, então os dados de condenações apresentados nesse estudo referem-se à avaliação aproximada de 15.552 aves, sendo que metade desse valor foi referente às aves criadas em aviários com sistema de pressão positiva e metade em pressão negativa. As porcentagens de condenação total das carcaças nos galpões de pressão positiva foram 0,28% e pressão negativa foram 0,33%. Já as porcentagens de condenações parciais foram 0,31% nos galpões de pressão positiva e 0,61% de pressão negativa. As principais perdas produtivas oriundas das condenações totais (aspecto repugnante e síndrome ascítica) neste estudo foram maiores nos galpões de pressão negativa em relação aos de pressão positiva, porém, a caquexia se apresentou 55,55% maior nos galpões de pressão positiva. Já nas condenações parciais, a síndrome ascítica manteve o mesmo padrão das condenações totais, sendo maior nos galpões de pressão negativa. Conclui-se com este trabalho que o valor médio da porcentagem de condenações totais e parciais foi 0,50%, abaixo dos resultados encontrados na literatura. Apresentando diferença estatística significativa (p < 0,05) entre os galpões na incidência de síndrome ascítica (condenação parcial) e lesões de asas, sendo maior os galpões de pressão negativa, e lesões de peito sendo maior nos galpões de pressão positiva. A principal causa de condenação em ambos os galpões foi parcial devido a contusão e fratura nas carcaças. Nos galpões de pressão negativa, as principais condenações foram aspecto repugnante e síndrome ascítica. Já nos galpões de pressão positiva, foram caquexia e celulite.
Atmospheric boundary layer sources for upper tropospheric air over the Asian summer monsoon region
Creators: name: Qiu-Jun Fan
name: Bian, Jian-Chun
name: Pan, Laura L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Inorganic Chemistry
subject: Science Policy

description: Previous satellite measurements and model simulations have shown that the Asian summer monsoon (ASM) anticyclone is co-located with higher concentrations of pollutants, which are emitted in the continental atmospheric boundary layer (ABL). Backward trajectory calculations show that the air at the 150-hPa level has the maximum frequency of ABL sources within 30 days over the most intensive convection regions and their downwind areas, which are not located within the ASM anticyclone, but rather at the southern flank or periphery of the ASM anticyclone. The upper tropospheric airs originated from the ABL sources include two parts: one from the ocean, which has the dominant impact to the south of 20°N, particularly over the South China Sea (SCS) and the west tropical Pacific Ocean; and another from the continent, which is dominant between 10°N and 30°N, particularly over the Bay of Bengal (BoB), continental India, the Arabian Sea, and the Arabian Peninsula. It is the latter part that forms the higher pollutant concentration within the ASM anticyclone as shown by satellite measurements. Air in the ABL sources (both polluted and unpolluted) converges to the intensive convection region in the lower troposphere, and then traverses the middle troposphere through a wide group of upward pipes, and finally to the upper troposphere. These pipes in the middle troposphere are defined by the ASM intensive convections and cover the south of continental India, the BoB, the Tibetan Plateau, the Indochina Peninsula, the SCS, and the Philippine Sea.
title: saint Célestin V
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Moine bénédictin fondateur de l'ordre des célestins et de la congrégation d'ermites du mont majella ; pape en 1294 ; canonisé par Clément V, en 1313, sous le nom de saint Pierre-Célestin ; attributs : une colombe, la tiare pontificale à ses pieds
Techni-Composite Higgs models with (a)symmetric dark matter candidates
Creators: name: Soerensen, Philip
name: Frandsen, Mads Toudal
name: Huang, Wei-Chih
name: Cacciapaglia, Giacomo
name: Rosenlyst, Martin
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2021
Subjects: subject: 530
subject: model: composite
subject: temperature: high
subject: dark matter: asymmetry
subject: Higgs model
subject: symmetry: left-right
subject: electroweak interaction
subject: gauge field theory: SU(2) x SU(2) x U(1)
subject: sphaleron
subject: technicolor

description: Physical review letters (2021).
description: We propose a novel class of composite models that feature both a technicolor and a composite Higgs vacuum limit, resulting in an asymmetric dark matter candidate. These Techni-Composite Higgs models are based on an extended left-right electroweak symmetry with a pseudo-Nambu Goldstone boson Higgs and stable dark matter candidates charged under a global $\mathrm{U}(1)_X$ symmetry, connected to the baryon asymmetry at high temperatures via the $SU(2)_{\rm R}$ sphaleron. We consider, as explicit examples, four-dimensional gauge theories with fermions charged under a new confining gauge group $G_{\rm HC} $.
description: Published by APS, College Park, Md.
title: A la mémoire du Comte Albert Apponyi
title: son rôle dans la politique internationale, la philosophie, le droit public, la vie interparlamentaire, ses voyages en Amérique
titleType: Subtitle
title: par Ivan Praznovszky, Jules Kornis, Etienne Egyed, Léopolde Boissier et André Sebestyén
titleType: Subtitle
Creators: name: Praznovszky, Ivan
name: Kornis, Gyula
name: Egyed, Etienne
name: Boissier, Leopolde
name: Sebestyén, André
Publisher: name: Société de la Nouvelle Revue de Hongrie
Year: 1943
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Apponyi, Albert von
subject: Ungarn

description: Inhalt: Le rôle du comte Apponyi dans la politique internationale / par Ivan Praznovszky ; La philosophie d'Apponyi / par Jules Kornis ; Apponyi et le droit public / par Etienne Egyed ; Apponyi interparlementaire / par Léopold Boissier ; Le comte Albert Apponyi et l'Amérique / par André Sebestyén