cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Procedural sedation by advanced practice providers in the emergency medical service in the Netherlands: a retrospective study
Creators: name: van Vliet, Risco
name: Breedveld, Lennert
name: Heutinck, Annemieke A.J.
name: Ockeloen, Bram H.A.
name: van ’ Hof, Arnoud W.J.
name: Moors, Xavier R.J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 1
Syntormon setosum Parent 1938
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon setosum

description: 258. Syntormon setosum Parent, 1938 (Sympycninae)
HR: Spring Sveti Spas, Cetina River (Pollet & Ivković 2018).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 464, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Additional file 1 of The effects of real-time waveform analysis software on patient ventilator synchronization during pressure support ventilation: a randomized crossover physiological study
Creators: name: Nakornnoi, Barnpot
name: Tscheikuna, Jamsak
name: Rittayamai, Nuttapol
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Medicine
Cell Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Supplementary Material 1
A novel N7-Methylguanine-related gene signature for predicting prognosis in acute myeloid leukemia: bioinformatic analysis and experimental verification
Creators: name: Zhao, Ranran
name: Yang, Lulu
name: Liu, Chenchen
name: Jiang, Ruoyu
name: Huang, Qianlei
name: Wang, Qin
name: Wu, Xiaojin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Background: The involvement of N7-Methylguanine (m7G) RNA methylation regulators in the progression of different types of solid cancers in humans has been established. However, the specific impact of m7G-related genes on Acute myeloid leukemia (AML) remains uncertain. Our research aims to build a novel signature of M7Gs that could enhance our understanding of the molecular heterogeneity in leukemia. Methods: The RNA-seq and clinical data of patients with AML were acquired from the UCSC XENA website. Prognostic-related genes were selected using LASSO to construct a risk-scoring model. External datasets were utilized to validate the effectiveness of the model, and the mRNA expressions of candidate genes were measured using RT-qPCR. Results: A prognostic model was developed using a risk-scoring approach based on three candidate genes (IFIT5, EIF4E2, and LARP1) and their respective risk coefficients. Multivariate Cox regression analysis revealed a significant association between the risk score and overall survival (p<0.001). In both the experimental and validation cohorts, individuals classified as high risk exhibited a poorer prognosis. The 5-year area under the curve (AUC) was calculated as 0.715 for the TCGA-LAML cohort and 0.646 for GSE37642. Additionally, analysis using ssGSEA demonstrated that the high-risk group exhibited higher levels of immune cell infiltration compared to low-risk group. RT-qPCR results indicated that the expression levels of LARP1, EIF4E2 and IFIT5 were consistent with the results of the bioinformatic analysis. Conclusions: In summary, the m7G-related genes are potential prognostic biomarkers for patients with AML.
Metabolomics-based study on the significance of differential metabolite binding IgG isoforms in Hemolytic disease of newborn
Creators: name: Zhang, Shipeng
name: Li, Sijin
name: Meng, Xuan
name: Chen, Jia
name: Tang, Yan
name: Li, Xiaobin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences

description: Hemolytic disease of the newborn (HDN) is a common condition that can have a severe impact on the health of newborns due to the hemolytic reactions it triggers. Although numerous studies have focused on understanding the pathogenesis of HDN, there are still many unanswered questions. In this retrospective study, serum samples were collected from 15 healthy newborns and 8 infants diagnosed with hemolytic disease. The relationship between different metabolites and various IgG subtypes in Healthy, HDN and BLI groups was studied by biochemical technique and enzyme-linked immunosorbent assay (ELISA). Metabolomics analysis was conducted to identify the differential metabolites associated with HDN. Subsequently, Pearson's correlation analysis was used to determine the relation of these differential metabolites with IgG isoforms. The relationship between the metabolites and IgG subtypes was observed after treatment. The study results revealed that infants with hemolytic disease exhibited abnormal elevations in TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4 levels when compared to healthy newborns. Additionally, differences in metabolite contents were also observed. N, N-DIMETHYLARGININE showed negative correlations with TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4, while 2-HYDROXYBUTYRATE, AMINOISOBUTANOATE, Inosine, and ALLYL ISOTHIOCYANATE exhibited positive correlations with TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4. Through metabolomics-based research, we have discovered associations between differential metabolites and different IgG isoforms during the onset of HDN. These findings suggest that changes in metabolite and IgG isoform levels are linked to HDN. Understanding the involvement of IgG isoforms and metabolites can provide valuable guidance for the diagnosis and treatment of HDN.
Syntormon silvianum Parvu 1989
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon silvianum

description: 259. Syntormon silvianum Pârvu, 1989 (Sympycninae)
HR: Štirovača, North part of Velebit Mountain (Pollet & Ivković 2018); RS: Ceremošnja (Pârvu 1997).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 464, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Additional file 1 of A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes
Creators: name: Kim, Gyuri
name: Kim, Seohyun
name: Lee, You-Bin
name: Jin, Sang-Man
name: Hur, Kyu Yeon
name: Kim, Jae Hyeon
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1.
Clinical characterization of hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors: a review of published cases
Creators: name: Xu, Zhiya
name: Li, Huilan
name: Yu, Xinyi
name: Luo, Jia
name: Zhang, Zanling
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Virology

description: An association exists between immune checkpoint inhibitors and hemophagocytic lymphohistiocytosis (HLH). Therefore, the main objective of this study was to collect data on this rare but potentially life-threatening immune-related adverse reaction to identify the medications that cause it, the clinical characteristics, and effective treatments. Literature in English and Chinese on immune checkpoint inhibitors causing HLH published from August 2014 to March 2024 was analyzed. Immune checkpoint inhibitors, immunotherapy, anti-PD-1, PD-L1 inhibitors, HLH, hemophagocytic lymphohistiocytosis, hemophagocytic syndrome keywords were used to find the literature on China Knowledge Network, Wanfang, PubMed and Emabase Databases. Twenty-four studies were included, with a total of 27 patients (18 males and 9 females) with a mean age of 58 years (range 26–86). The mean time to the onset of symptoms was 10.3 weeks (7 days–14 months). The main clinical characteristics were fever, cytopenia, splenomegaly, methemoglobinemia, hypofibrinogenemia, and bone marrow biopsy showed phagocytosis. Twenty-two patients improved after the treatment with steroids, cytokine blocking therapy and symptomatic treatment, four patients died, and one patient was not described. HLH should be not underestimated as a potentially serious adverse effect of immune checkpoint inhibitors since appropriate treatments may save the life of patients.
ROSiE Case Collection: Responsible Open Science
Creators: name: Mežinska, Signe
name: Neiders, Ivars
Publisher: name: Zenodo
Year: 2024
Subjects: Open Science
research ethics
research integrity
training
case collection
cases

description: This is a case collection for the ROSiE Training Materials for Responsible Open Science. Many cases included in this material are used in the ROSiE traditional and online training materials; however, if trainers want to use additional cases or address a topic that is not directly addressed in the training materials, they might consult this collection of cases. This material can also be used independently from the training materials for any course addressing ethical issues in open science and citizen science. Additionally, for six of the cases there are animations available on youtube and on the ROSiE Knowledge Hub.

After each case, there are questions for discussion, as well as supplementary readings that may be used by a trainer or assigned as required or optional readings for trainees. The case collection includes an index (p. 5) where cases are grouped according to field of science, stage of research and topic.

Links to the traditional training materials: 

Social Sciences

Natural Sciences

Humanities

Health and Life Sciences

Citizen Scientists
The significance of MRD-based strategy by dynamic assessment to guide treatment decisions in B-ALL – the enlightenment provided by demonstrating survival differences in the retrospective study
Creators: name: Chen, Yongyu
name: Liu, Rongrong
name: Li, Jing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: The study aimed to access the impact of related factors on the long-term survival of patients with B-cell acute lymphoblastic leukemia (B-ALL) by analyzing clinical characteristics of B-ALL patients, and observed the significance of dynamic measurable residual disease (MRD) assessment for the prognosis and treatment selection of B-ALL patients, aiming to deepen the understanding of the disease and improve the survival prognosis of B-ALL patients. The clinical characteristics of 65 patients with B-ALL were collected to calculate the median overall survival (OS) and median disease-free survival (PFS), and to evaluate the significance of survival analysis guided by dynamic MRD assessment. The survival analysis based on dynamic MRD assessment suggested that B-ALL patients who maintained MRD negative status during dynamic assessment after induction chemotherapy had better survival outcomes in the comparison of progression-free survival between subgroups, with statistically significant differences (P = 0.0002 (HR: 0.26, 95% CI: 0.13-0.51)). High-risk B-ALL patients who maintained negative MRD status during dynamic assessment after induction chemotherapy had longer median progression – free survival, and the survival difference between subgroups was statistically significant (P = 0.0016 (HR: 0.28, 95% CI: 0.09-0.48)). Dynamic MRD assessment had significant clinical value: maintaining negative MRD status during dynamic assessment can improve the prognosis and survival of B-ALL patients; dynamic MRD assessment after induction chemotherapy can help guide subsequent treatment, which could provide reference for the advancement of future treatment strategies.
Syntormon subinermis Sympycninae
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon subinermis

description: 260. Syntormon subinermis (Loew, 1869) (Sympycninae)
RO-DO: Hagieni, Constanta province (Pârvu 1987; Skolka 2003).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 464, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Nomogram models predicting prognosis for patients with t(8;21) acute myeloid leukemia: a SEER-based study
Creators: name: Yang, Jiapeng
name: Zhu, Xiaohua
name: Zhang, Honghong
name: Fu, Yang
name: Li, Zifeng
name: Xing, Ziping
name: Yu, Yi
name: Cao, Ping
name: Le, Jun
name: Jiang, Junye
name: Li, Jun
name: Wang, Hongsheng
name: Qian, Maoxiang
name: Zhai, Xiaowen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Acute myeloid leukemia (AML) with t(8;21) manifests as a diverse hematological malignancy. Although it was categorized into a favorable subtype, 30–40% of patients experience relapse. The objective of this research was to devise a nomogram for the accurate anticipation of both overall survival (OS) and cancer-specific survival (CSS) in t(8;21) AML. From the Surveillance, Epidemiology, and End Results (SEER) database, individuals diagnosed with t(8;21) AML from 2000 to 2018 were selected. Prognostic factors for t(8;21) AML were identified using Cox regression analysis and Akaike Information Criterion (AIC), forming the basis for constructing prognostic nomograms. Key variables, including first primary tumor, age group, race, and chemotherapy, were identified and integrated into the nomogram. The C-index values for the nomograms predicting OS and CSS were 0.753 (validation: 0.765) and 0.764 (validation: 0.757), respectively. Ultimately, based on nomogram scores, patients were stratified into high-risk and low-risk groups, revealing significant disparities in both OS and CSS between these groups (P < 0.001). This study innovatively crafted nomograms, incorporating clinical and therapeutic variables, to forecast the 1-, 3-, and 5-year survival rates for individuals with t(8;21) AML.
Efficacy of daratumumab on multiple myeloma patients with renal insufficiency: a systematic review and meta-analysis
Creators: name: Jiang, Hua
name: Li, Lu
name: Guo, Meiyu
name: Li, Meizhang
name: Wu, Hao
name: Chen, Xiaomei
name: Gao, Mingzhao
name: Xu, Qianqian
name: Mi, Jia
name: Cui, Canchan
name: Fu, Weijun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Marine Biology
Cancer
Science Policy
Hematology

description: Renal insufficiency (RI) is a key factor affecting the prognosis of multiple myeloma (MM) patients. Because the benefit of daratumumab for treating MM patients with RI remains unclear, our objective was to evaluate the efficacy of daratumumab on MM patients with RI. We conducted a systematic search of the PubMed, EMBASE, and Cochrane Library databases as of October 24, 2023. Two independent reviewers screened the article titles, abstracts, and full text to identify the randomized controlled trials (RCTs) meeting the inclusion and exclusion criteria. Meta-analyses were performed using RevMan version 5.4. Outcomes of interest were progression-free survival (PFS), overall survival (OS), complete response or better (≥CR), and minimal residual disease (MRD) negativity, all calculated as hazard ratios (HRs) or risk ratios (RRs) with 95% confidence intervals (CIs). A total of 10 RCTs with 5003 patients were included. Add-on daratumumab improved PFS and OS among newly diagnosed MM (NDMM) patients with RI (HR 0.48 [95% CI: 0.36, 0.64, I2 = 65%] and HR 0.63 [95% CI: 0.48, 0.82, I2 = 0%]) as well as relapsed/refractory MM (RRMM)-RI patients, compared with the control group (HR 0.46 [95% CI: 0.37, 0.58, I2 = 0%] and HR 0.68 [95% CI: 0.51, 0.92, I2 = 0%]). In terms of the renal status, the efficacy of add-on daratumumab for MMRI patients was similar to that for MM patients with normal renal function. A prolonged PFS benefit for add-on daratumumab treatment versus the control was evident across all RRMM-RI subgroups, and the benefits tended to increase with the follow-up time. Our results indicate that MM patients with RI could benefit from a daratumumab-added regimen regardless of MM status. Additional high-quality RCTs are still warranted to confirm our findings.
Syntormon tabarkae Becker 1918
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon tabarkae

description: 261. Syntormon tabarkae Becker, 1918 (Sympycninae)
GR: (Grichanov 2007).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Syntormon triangulipes Becker 1902
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon triangulipes

description: 262. Syntormon triangulipes Becker, 1902 (Sympycninae)
BG: Tekirska River (Kechev 2014); Omurovska River near Cherna Gora village (Kechev et al. 2014).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Epidemiological characteristics and influencing factors of acute leukemia in children and adolescents and adults: a large population-based study
Creators: name: Liu, Shuojie
name: Hu, Bin
name: Zhang, Jiaqin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: To assess the epidemiological characteristics and prognostic factors of acute leukemia (AL) in children and adolescents, and make comparisons between pediatric and adult patients. This retrospective cohort study enrolled AL patients from the Surveillance, Epidemiology, and End Results (SEER) 1975–2016. OS in children and adolescents and adults with AL was compared and analyzed separately by age and AL subtype. Totally 61,694 AL patients were identified, with 45,411 (73.6%) adults and 16,283 (26.4%) children and adolescents. From 2000 to 2016, the incidence rates of AL [annual percent changes (APC) = 1.2, 95%CI = 0.9–1.6, P < 0.05] and acute lymphoblastic leukemia (ALL) (APC = 1.5, 95%CI = 1.1–1.8, P < 0.05) in children and adolescents were significantly increasing. For adults, AL (APC = 0.9, 95%CI = 0.3–1.5, P < 0.05), ALL (APC = 2.5, 95%CI = 2.0–3.1, P < 0.05) and acute myeloid leukemia (AML) (APC = 0.9, 95%CI = 0.4–1.5, P < 0.05) had significantly elevated incidence rates. Overall survival (OS) in children and adolescents with AL was significantly higher than that in adults with AL (log-rank P < 0.0001). OS in children and adolescents and adults with ALL, AML and AUL decreased with age (all log-rank P < 0.0001). Older age, male sex and black race were risk factors for the survival of children and adolescents and adults with ALL, AML and AUL. From 2000 to 2016, the incidence rates of AL in children and adolescents and adults were increasing. Children and adolescents with AL had significantly better OS than adults with AL, and OS declined with age in both children and adolescents and adults with ALL, AML and AUL.
An observational study of haemophilia A patients without inhibitors using the French national claims (SNDS) database
Creators: name: Trossaërt, Marc
name: Falk, Aletta
name: Gautier, Laurène
name: Kragh, Nana
name: Van Hinloopen, Olivia
name: Varin, Remi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Mental Health
Hematology

description: To describe clinical characteristics, factor consumption, and events of interest in patients with haemophilia A without inhibitors receiving prophylaxis in France, and the clinical impact of switching to Elocta® in this population. This retrospective, observational study using the Système National des Données de Santé database, analysed data from patients with haemophilia A without inhibitors using prophylactic factor VIII (FVIII) replacement therapy during 2016–2019. Clinical characteristics, treatment patterns and switches, factor consumption, and rate of events of interest were determined. In a sub-cohort of patients treated with Elocta®, clinical characteristics, factor consumption, and rate of events of interest before and after switching to Elocta® were compared. For 545 patients, with mean age (standard deviation [SD]) 25.4 (17.8) years, Elocta® was the most used treatment. Bleeding events and articular non-bleeding events leading to hospitalization occurred in 15.4% and 13.9% of patients, respectively, and 9.9% of patients had surgeries or procedures related to haemophilic arthropathy. The mean (SD) FVIII product consumption was 344 (93) IU/kg/month for extended half-life treatment, and 331 (98) IU/kg/month for standard half-life products. For the sub-cohort of 146 patients, bleeding events (SD) decreased from 0.32 (2.2) to 0.09 (0.42) events/patient/year (p = 0.227) after switching to Elocta®. There was no statistically significant difference in rates of factor consumption or articular non-bleeding events before and after initiation of Elocta®. This study provides real-world insights that advance the understanding of treatment patterns and events of interest in patients with haemophilia A on prophylactic regimens in France.
Syntormon zelleri Sympycninae
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Syntormon
Syntormon zelleri

description: 263. Syntormon zelleri (Loew, 1850) (Sympycninae)
RO-DO: Furnica, Constanta province (Pârvu 2001).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Global research trends in traditional Chinese medicine therapy for acute leukemia: a comprehensive visualization and bibliometric analysis
Creators: name: Zhang, Wenwen
name: Zhang, Kaili
name: Feng, Yuqing
name: Zhang, Gaofeng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Cancer
Science Policy
Hematology

description: The application of traditional Chinese medicine (TCM) therapy to acute leukemia has been intensively investigated. However, the bibliometric analysis in this field has not been performed. This bibliometric study aimed to comprehensively analyze the research trends and active areas of TCM therapy for acute leukemia from 2000 to 2023. We searched articles and reviews published between 2000 and 2023 that discussed TCM in acute leukemia from the Web of Science Core Collection (WoSCC). Knowledge mapping and bibliometric analysis were conducted using VOSviewer, CiteSpace software, and R-bibliometrix. A total of 1,099 articles were included, with China, the United States, and Korea contributing the most papers. Most papers were published in the Journal of Ethnopharmacology. Meanwhile, China saw a steady increase in the number of publications. The three leading institutions that made outstanding contributions were the China Medical University, the Chinese Academy of Sciences, and the China Academy of Chinese Medical Sciences. Efferth Thomas, Liu Wei, and Liu Jie were the top three productive authors, with Efferth T receiving the most co-citations. The most frequently cited reference was Shen ZX (1997). In the analysis of keywords co-occurrence, ‘survival,’ ‘risk factors,’ ‘nanoparticles,’ and ‘metabolism’ are the active research topics. This bibliometric study provides researchers with a comprehensive overview and significant value in understanding the development of TCM in acute leukemia treatment.
Additional file 1 of Diet quality as assessed by the healthy eating index-2020 among different smoking status: an analysis of national health and nutrition examination survey (NHANES) data from 2005 to 2018
Creators: name: Luo, Ting
name: Tseng, Tung-Sung
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Supplementary Material 1.
title: Ultrashort Peptide Grafting on Mesoporous Films and Its Impact on Ionic Mesopore Accessibility
Creators: name: Bagherabadi, Mohadeseh
name: Andrieu-Brunsen, Annette
Publisher: name: ACS
Year: 2025

description: An approach for direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the amino acids arginine, leucine, and glycine is presented. Although the number of grafted amino acids remains low, the ionic mesopore accessibility can be gradually adjusted. The addition of arginine in up to five reaction cycles leads to a progressive increase in positive mesopore charge density, which gradually increases the anionic mesopore accessibility at acidic pH. At basic pH, the remaining silanol groups at the pore wall still dominate counter-charged cation mesopore accessibility. Thus, specific peptide sequence design is demonstrated to be a sensitive tool for molecular transport control in nanoscale pores. Overall, the direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the sequences of different amino acids opens up exciting opportunities for the development of innovative materials with precisely tailored properties and functions based on specific peptide sequence design.
Systenus bartaki Naglis 2017
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Systenus
Systenus bartaki

description: 264. Systenus bartaki Naglis, 2017 (Medeterinae)
HR: Gornji Muć, about 15 km northeast Split (Naglis 2017).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
A combined immune and exosome-related risk signature as prognostic biomakers in acute myeloid leukemia
Creators: name: Fang, Zenghui
name: Fu, Jiali
name: Chen, Xin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Acute myeloid leukemia (AML) is one of the common hematological diseases with low survival rates. Studies have highlighted the dysregulated expression of immune-related and exosome-related genes (ERGs) in cancers. Nevertheless, it remains to be determined whether combining these genes have a prognostic significance in AML. Immune-ERG profiles for 151 AML patients from TCGA were analyzed. A risk model was constructed and optimized through the combination of univariate Cox regression and LASSO regression analysis. GEO datasets were utilized as the external validation for the robustness of the risk model. In addition, we performed KEGG and GO enrichment analyses to investigate the role played by these genes in AML. The variations in immune cell infiltrations among risk groups were assessed through four algorithms. Expression of hub gene in specific cell was analyzed by single-cell RNA seq. A total of 85 immune-ERGs associated with prognosis were identified, enabling the construction of a risk model for AML. The risk model based on five immune-ERGs (CD37, NUCB2, LSP1, MGST1, and PLXNB1) demonstrated a correlation with the clinical outcomes. Additionally, age, FAB classification, cytogenetics risk, and risk score were identified as independent prognostic factors. The five immune-ERGs exhibited correlations with cytokine-cytokine receptor interaction, and antigen processing and presentation. Notably, the risk model demonstrated significant associations with immune responses and the expression of immune checkpoints. An immune-ERG-based risk model was developed to effectively predict prognostic outcomes for AML patients. There is potential for immune therapy in AML targeting the five hub genes.
Binolarning energiya tejamliligini oshirishning ta'sir ko'rsatkichlari va yechimlari
Creators: name: Erdashev Tayir Farxad ulı, Torebek Uzaqov
Publisher: name: Zenodo
Year: 2024

description: Annotatsiya: Binolarning energiya samaradorligini oshirish hamda xalqaro tajribaga yondashgan holda qurilish sestimasi tahlil qilib o’tildi. Bugungi kunda qurilayotgan binolarning umumiy holati xalqaro tajribaga mos shaklda yaratilmoqda. Maqola Binolarning energiya tejamliligini oshirishning ta'sir ko'rsatkichlari va yechimlari haqida yoritilgan.

Kalit so‘zlar: Bino, tejamkorlik, energiya, islohot, yechim, diskomfort , energiya sarfi, izolyatsiya.

Аннотация: Проанализирована система зданий с учетом повышения энергоэффективности зданий и международного опыта.  Сегодня общее состояние строящихся зданий создается согласно международному опыту.  В статье описаны показатели воздействия и решения по повышению энергоэффективности зданий.

 Ключевые слова: Строительство, экономика, энергетика, реформа, решение, дискомфорт, энергопотребление, изоляция.

Abstract: The building system is analyzed taking into account increasing the energy efficiency of buildings and international experience.   Today, the general condition of buildings under construction is created in accordance with international experience.   The article describes impact indicators and solutions for improving the energy efficiency of buildings.

  Key words: Construction, economics, energy, reform, solution, discomfort, energy consumption, insulation.
Systenus bipartitus Medeterinae
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Systenus
Systenus bipartitus

description: 265. Systenus bipartitus (Loew, 1850) (Medeterinae)
HR (Pollet 2011; Drake 2018).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients
Creators: name: Wang, Kai
name: Si, Tianyu
name: Wei, Congmin
name: Hu, Qi
name: Zhou, Yongming
name: Bao, Jizhang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Myelodysplastic syndrome (MDS) is characterized by activated inflammatory signaling and affects prognosis. Targeting inflammatory signaling may provide a way to treat the disease. We were curious whether there were changes in A20 in peripheral blood mononuclear cells (PBMC) of MDS patients. Therefore, we conducted a study with 60 clinical samples, including 30 MDS patients and 30 healthy controls. All patients with MDS were diagnosed and classified according to the criteria of the 2016 World Health Organization. The study was performed in accordance with the guidelines of the Declaration of Helsinki. Using Quantitative Real-Time RT–PCR, we discovered that A20 mRNA expression in PBMC of the MDS group was significantly lower than that in the control group (P < 0.001). Additionally, using Luminex Liquid Suspension Chip, we observed elevated plasma levels of pro-inflammatory IL-8 and TNF-α in the MDS group compared to the healthy control group (P < 0.001). We did not find a significant correlation between A20 mRNA and clinical characteristics (age, sex, concentration of hemoglobin, neutrophils count, platelets count, percent of blasts, and WHO classification) of the patients, nor between A20 mRNA and plasma cytokines (data not shown). Our study found down-regulated of A20 and increased levels of pro-inflammatory cytokines in the peripheral blood of MDS patients, providing further evidence for the activation of inflammatory signals in MDS.
Tachytrechus consobrinus Dolichopodinae
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Tachytrechus
Tachytrechus consobrinus

description: 266. Tachytrechus consobrinus (Haliday, 1851) (Dolichopodinae)
BG: Markovo village, West Rhodope Mts. (Kechev 2010, 2011b); Kayaliika River near Scobelevo village (Ke-chev 2014).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Tachytrechus genualis Loew 1857
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Tachytrechus
Tachytrechus genualis

description: 267. Tachytrechus genualis Loew, 1857 (Dolichopodinae)
BG: Pancharevo, near Sofia (Nedelkov 1912); RS: Kalna, Timok River (Grichanov 2016).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia
Creators: name: Nukui, Jun
name: Tachibana, Takayoshi
name: Miyazaki, Takuya
name: Tanaka, Masatsugu
name: Matsumoto, Kenji
name: Ishii, Yoshimi
name: Numata, Ayumi
name: Nakajima, Yuki
name: Matsumura, Ayako
name: Suzuki, Taisei
name: Izumi, Akihiko
name: Hirose, Natsuki
name: Yamamoto, Koji
name: Hagihara, Maki
name: Fujisawa, Shin
name: Nakajima, Hideaki
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Our previous study showed that a high pre-transplant nucleated cell count in the bone marrow is associated with increased non-relapse mortality (NRM) and decreased overall survival (OS) in patients with acute lymphoblastic leukemia (ALL) in remission. In this retrospective multicenter study, we aimed to examine the association between nucleated cell subfractions and transplant outcomes using the same patient cohort as our previous study. This study included patients with ALL who underwent their first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2010 and 2022. The patients were stratified into high and low cell group levels to compare transplant outcomes using cutoff values for predicting OS in each subfraction determined using receiver operating curves. In the cohort of 134 patients, the median values for myeloid, erythroid, monocyte, and lymphocyte series were 16,860/µL (468–229,296), 15,584/µL (34–246,992), 1,446/µL (70–25,296), and 4,215/µL (90–33,856), respectively. The univariate analysis showed that the groups with high levels of myeloid cells (≥38,000/µL, n = 48), erythroid cells (≥25,000/µL, n = 45), and monocyte cells (≥4,200/µL, n = 44) were all associated with worse 3-year OS and higher NRM than the low-level groups. These findings were confirmed by using multivariate analysis. The high cell count group showed a higher incidence of NRM associated with acute graft-versus-host disease or immunological disorders. High myeloid, erythroid, and monocytic cell levels in the bone marrow before allo-HSCT may independently increase the risk of NRM and reduce OS.
Seagrass and Humans: A Tangled Tale - How do humans and seagrass interact in complex connections in Indonesia?
Creators: name: Reza, Akbar
name: Astari, Elisabeth
Publisher: name: QUBES Educational Resources
Year: 2025

description: Students explore seagrass ecosystems via satellite imagery, field surveys, and data interpretation, linking ecological health to human well-being. The module blends science and society, building spatial analysis skills, systems thinking, and conservation.
Tachytrechus insignus Dolichopodinae
Creators: name: Kechev, Mihail
name: Naglis, Stefan
name: Tonguç, Alper
name: Pollet, Marc
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Tachytrechus
Tachytrechus insignus

description: 268. Tachytrechus insignus (Stannius, 1831) (Dolichopodinae)
BG: Burgas (Nedelkov 1912).
description: Published as part of Kechev, Mihail, Naglis, Stefan, Tonguç, Alper & Pollet, Marc, 2020, Checklist of the Dolichopodidae (Diptera, Empidoidea) of the Balkan Peninsula with first records for Bulgaria, Montenegro, North Macedonia, and for the European part of Turkey, pp. 436-472 in Zootaxa 4819 (3) on page 465, DOI: 10.11646/zootaxa.4819.3.2, http://zenodo.org/record/4397053
When Chinese patients with plasma cell disorders encountered the nationwide Omicron outbreak (December 2022): a real-world multicenter and multiregional study
Creators: name: Jiang, Xincheng
name: Han, Xiaoyan
name: Jin, Fengyan
name: An, Gang
name: Hou, Jian
name: He, Jingsong
name: Wang, Qingming
name: Wu, Wenjun
name: Zhao, Yi
name: Jiang, Songfu
name: Li, Shuchan
name: Xu, Zhenshu
name: Zheng, Gaofeng
name: Yang, Yang
name: Chen, Qingxiao
name: He, Donghua
name: Li, Yi
name: cai, zhen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: This study aims to assess the impact of the nationwide Omicron outbreak in December 2022 on Chinese patients with plasma cell disorders (PCD), focusing on the clinical characteristics of PCD patients with COVID-19 and the risk factors contributing to adverse clinical courses (severity and hospitalization) and outcomes. A multicenter retrospective study was performed from December 1, 2022, to January 19, 2023. The study population includes 404 PCD patients, divided into a COVID-19 group (n = 342) and an uninfected group (n = 62). The frequency of COVID-19 infection was 84.7% (342/404), and 16.4% (56/342) were severe COVID-19. Among the 277 patients with complete follow-up, 2 deaths (0.7%) were reported, while 231 (83.4%) recovered from COVID-19. Age > 65 (P = 0.02) and prior anti-CD38 monoclonal antibody (mAb) treatment within six months (P = 0.03) were independent risk factors for severe infection. Additionally, previous chimeric antigen receptor T-cell (CAR-T) therapy within six months was correlated with a higher risk of hospitalization (P = 0.04) and prolonged recovery time (P = 0.03). No significant protective effect of vaccination on infection or severe infection was observed (P > 0.05). The latest Omicron outbreak results in higher rates of severe infection and mortality in PCD patients compared with the general population in China, highlighting the need to protect this vulnerable population during the pandemic. Recent use of anti-CD38 mAb and CAR-T therapy are associated with poorer clinical courses and outcomes of PCD patients with COVID-19.
Serum indicators in functional high-risk multiple myeloma patients undertaking proteasome inhibitors therapy: a retrospective study
Creators: name: Zhan, Linquan
name: Yuan, Dai
name: Ge, Xueling
name: Ding, Mei
name: Wang, Jianhong
name: Zhou, Xiangxiang
name: Wang, Xin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Multiple myeloma (MM) is a class of malignant plasma cell diseases. An increasing application of autologous stem cell transplantation (ASCT) and anti-myeloma agents represented by proteasome inhibitors (PIs) has improved the response rates and survival of MM patients. Patients progressing within 12 months were recently categorized with functional high-risk (FHR), which could not be clarified by existing genetic risk factors, with poor outcomes. Our study aimed to investigate clinical indices related to FHR and seek prognostic roles in transplant-eligible MM patients. Demographic and individual baseline clinical characteristics were compared by using the Pearson's chi-square and Mann-Whitney U test. Progression-free survival (PFS) and overall survival (OS) were described by Kaplan-Meier estimates and compared using the log-rank test. Logistic regression analysis was used to assess the association of baseline characteristics at MM diagnosis with FHR status. From 18th January 2010 to 1st December 2022, 216 patients were included and divided into two groups according to the FHR status. There was no difference in baseline data between the two groups. Renal impairment (RI, Scr > 2 mg/dL) was common in MM patients and made sense in FHR status. AST levels were validated as independent predictors for FHR status (p = 0.019). Patients with RI or higher AST levels (AST > 40 U/L) tended to have worse outcomes. However, transplants had apparently improved prognoses. Therefore, in the PIs era, transplantations are still effective therapies for transplant-eligible MM patients.
Increased Th17 and Treg levels in peripheral blood positively correlate with minimal residual disease in acute myeloid leukaemia
Creators: name: Wang, Zhimin
name: Liu, Tangxia
name: Li, Yanru
name: Li, Zunchang
name: Bi, Kehong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Immune dysregulation plays a key role in acute myeloid leukemia (AML). We aimed to explore the correlation between T helper cell 17 (Th17) and the regulatory cells (Tregs) in the peripheral blood of patients with newly diagnosed (ND) AML and bone marrow blast cells, as well as minimal residual disease (MRD) before and after treatment. Changes in Th17 and Treg cells in the peripheral blood of 32 patients with ND AML were observed before and after induction chemotherapy with cytarabine for seven days and anthracycline for three days. The levels of inflammatory cytokines were measured using an enzyme-linked immunosorbent assay. Correlation analysis between bone marrow blast cells and Th17 and Treg cell frequencies was performed using the Pearson’s correlation test. Frequencies of Th17 and Treg cells and MRD were assessed using flow cytometry. IL-6, IL-10, IL-17A, and GM-CSF levels gradually increased in patients with ND AML and CR and NR patients. The percentages of Th17 and Treg cells positively correlated with those of blast cells. In addition, the frequencies of Th17 and Treg cells in MRD-positive patients were higher than those in MRD-negative patients at the initial induction and after three months of chemotherapy. The frequencies of Tregs and Th17 cells positively correlated with MRD onset. Increased Th17 and Treg cell levels were positively correlated with onset of AML, poor remission, and MRD.