cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Test and characterization of a prototype silicon-tungsten electromagnetic calorimeter
Creators: name: Muhuri, Sanjib
name: Mukhopadhyay, Sourav
name: Chandratre, Vinay B.
name: Sukhwani, Menka
name: Jena, Satyajit
name: Khan, Shuaib Ahmad
name: Nayak, Tapan K.
name: Saini, Jogender
name: Singaraju, Rama Narayana
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: New generation high-energy physics experiments demand high precision tracking and accurate measurements of a large number of particles produced in the collisions of lementary particles and heavy-ions. Silicon-tungsten (Si-W) calorimeters provide the most viable technological option to meet the requirements of particle detection in high multiplicity environments. We report a novel Si-W calorimeter design, which is optimized for $γ/π^0$ discrimination up to high momenta. In order to test the feasibility of the calorimeter, a prototype mini-tower was constructed using silicon pad detector arrays and tungsten layers. The performance of the mini-tower was tested using pion and electron beams at the CERN Proton Synchrotron (PS). The experimental results are compared with the results from a detailed GEANT-4 simulation. A linear relationship between the observed energy deposition and simulated response of the mini-tower has been obtained, in line with our expectations.
description: 13 figures, represents test beam data with PS beam line at CERN
Sex Differences in Vascular Reactivity During Acute and Chronic Hypoxia
Creators: Vanden Berg, Emily R
Publisher: name: University of Alberta Library
Year: 2022

BACKGROUND: Current evidence suggests that males and females regulate resting blood pressure differently. This may be a function of altered sympathetic activity, neurovascular coupling, or vascular smooth muscle receptor sensitivity. In this study, we wished to determine the role of α1-adrenoreceptors in vascular reactivity in both males and females with acute hypoxia exposure, and with early (day 2-3) and late (day 7-9) acclimatization to high-altitude hypoxia (White Mountain, CA; 3,800m). We hypothesized that 1) α1-adrenergic sensitivity would be attenuated with exposure to hypoxia, reducing vascular reactivity to sympathetic excitation and 2) females would exhibit lesser reactivity in comparison to males.

METHODS: We studied a convenience sample of 7 males and 6 females at three time points: 1) low altitude (Calgary AB, 1,045m) breathing room air (normoxia; LOW) and acute isocapnic hypoxia (PETO2 ~48mmHg; PETCO2 ~37mmHg; ACUTE); 2) during early (day 2-3; EARLY) and 3) late (day 7-9; LATE) acclimatization at high altitude (White Mountain, CA; 3,800m) breathing room air (PETO2 ~50mmHg) and hyperoxia (100% O2). Heart rate (HR; bpm), mean arterial pressure (MAP; mmHg), and blood oxygen saturation (SpO2; %) were collected beat-by-beat. Participants performed a cold pressor test (CPT) to assess integrated cardiovascular reactivity to a sympathetic stressor. To isolate α1-adrenergic receptor sensitivity, we delivered a graded series of phenylephrine hydrochloride (PE) injections. Statistical analysis included a mixed model ANOVA, and Holm-Sidak post hoc tests when we identified main effects (α<0.05).

RESULTS: α1-Adrenergic specific MAP sensitivity decreased with hypoxia (main effect P=0.0027). Similarly, hypoxic conditions were associated with attenuated maximal responses to CPT (main effect, P=0.0013). Males and females experienced similar blunting of α1-adrenergic mechanisms with hypoxia (P=0.6675). Though resting MAP and maximal responses to CPT were not statistically different between males and females (both P0.05), indicating adrenergic desensitization is the result of adaptive processes and not due to the acute effects of hypoxia.

CONCLUSIONS: Here, we have demonstrated that α1-adrenergic receptor mediated vascular reactivity is attenuated with high-altitude hypoxia similarly in males and females. This may be due to receptor desensitization caused by increased basal sympathetic nervous activity and resulting plasma neurotransmitter concentrations. However, there is evidence that males and females may adapt to tonically elevated sympathetic activity differently, which warrants further investigation. This study offers insight into resting and reflexive vascular regulation with acclimatization to hypoxia and has implications for males and females ascending to high altitude.
Participation of Japanese Women in Hard Rock and Heavy Metal
Creators: Heppleston, Thomas
Publisher: name: University of Alberta Library
Year: 2022

Hard rock and heavy metal are male–dominated music genres, yet despite a low status of women, Japan has a larger percentage of women performing hard rock and heavy metal than any other country with significant numbers of such bands. One possible explanation might be that music in Japan is historically less gendered than Western countries, and that this dynamic has carried forward into the modern Japanese hard rock and heavy metal subcultures. One prominent example of “less gendered” is the relative lack of instrument gender–stereotyping among Japan’s historical instruments, particularly the shamisen and tsuzumi–style drums, which were performed by both men and women. Guitars are an important instrument in hard rock and heavy metal, and the gender–neutral shamisen has similarities in both shape and performance techniques. Drums are also important to rock and metal, yet despite being heavily male–encoded in the West, Japan’s traditional drums do not share this same gender encoding. A survey of mostly female Japanese rock and metal musicians found that although many are either influenced or feel a connection to Japan’s historical instruments, the only instrument that they associated with gender was the shakuhachi, a bamboo flute that does have a male stereotype. Further to this, several respondents opined that the aggressive timbre of metal was inherently masculine, thereby echoing Western stereotypes. Respondents were also unaware of the professional pedagogical roles Japanese women played in the formal introduction of Western music to Japan during the late nineteenth and early twentieth century, which ran counter to contemporary Western attitudes; and they were also unaware of Japan’s all–female rock bands of the mid to late 1960s. However, survey responses suggested that other factors may contribute to Japanese women performing hard rock and heavy metal. These include the wardrobes of Japanese bands, Japan’s melodic sensibilities, and Japan’s convenient livehouse culture and public transportation system.
Production of scalar particles in electric field on de Sitter expanding Universe
Creators: name: Mihaela-Andreea, Băloi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The scalar particle production from vacuum in the presence of electric field, on the de Sitter spacetime is studied. We use perturbation methods to define the transition amplitude. We obtain that the momentum is not conserved in this process. The probability of pair production is computed by squaring the transition amplitude. Our graphical representations shows that, the probability of scalar particle production was important only in early stage of the universe, when the Hubble's constant was very large in comparison with the mass of the particle. Also we propose here a criteria of particle-antiparticle separation.
description: 13 pages, 6 figures
Die deutsche Orgeltabulatur New York Public Library Mus. Res. MN T 131 und das Breslauer Musikleben des 17. Jahrhunderts
Creators: name: Wiermann, Barbara
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Im Jahr 1962 machte Friedrich Blume erstmalig auf eine bis dahin unbeachtete deutsche Orgeltabulatur der New York Public Library aufmerksam. Er beschrieb die Quelle und ordnete sie in ihre Zeit ein. In einem weiteren Artikel thematisierte er die in dem Manuskript überlieferten Werke von Michael Praetorius. Kein Musikwissenschaftler hat sich seither eingehend mit der Tabulatur beschäftigt, obwohl zahlreiche Fragen bis heute offen sind. In diesem Beitrag wird die Orgeltabulatur vorgestellt und die Provenienz und die musikalischen Aktivitäten ihres Besitzers skizziert. Abschließend wird die Handschrift in den Kontext des Breslauer Musiklebens eingeordnet.
description: Schütz-Jahrbuch, Bd. 32 (2010)
Response from Demetrio Jimenez to John Brenneman, Building 131 50 Percent Level Plans, Fort Sam Houston, Texas
Creators: name: Jimenez, Demetrio
Publisher: name: Texas Historical Commission
Year: 1994
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Building 131
valueUri: https://core.tdar.org/browse/other-keyword/146283/building-131
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Texas Historical Commission has received and reviewed plans at the 50% level for the rehabilitation of Building 131 at Fort Sam Houston. It appears from the plans that a determination of "no adverse effect" will be determined, after a tour of the site by the Commission.
Heinrich Schütz und seine Brüder: Neue Stammbucheinträge
Creators: name: Rifkin, Joshua
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Artikel widmet sich Stammbucheinträgen von Heinrich Schütz und seinen Brüdern und liefert neue Einblicke in die Biografie von Schütz. (Barbara Alge) Bezugnehmend auf: Werner Breig: Die Stammbucheinträge von Heinrich Schütz, in: SJb 29 (2007), S. 81-109.
description: Schütz-Jahrbuch, Bd. 33 (2011)
The use of the ICF framework as an allied health outcomes measure: Australian Therapy Outcome Measures (AusTOMs)
Creators: name: Skeat, Jemimah
name: Perry, Alison
name: Unsworth, Carolyn
name: Morris, Meg
name: Duckett, Stephen
name: Dodd, Karen
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2023

description: Blank
A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?
Creators: name: Ting, Jenny P-Y
name: Wen, Haitao
name: O'Neill, Luke A J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The inflammasome is a protein complex that is comprised of an intracellular sensor that is typically an NLR protein, the pro-protein, procaspase-1 and adaptor molecule ASC. Inflammasome activation leads to caspase-1 maturation and the processing of its substrate, IL-1β and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, recent evidence suggests that inflammasome activation influences a host of metabolic disorders including atherosclerosis, type 2 diabetes, gout and obesity. Another aspect regarding inflammation in general and inflammasome in specific is that the activation process has a profound effect on aerobic glycolysis, or the Warburg effect. How the Warburg effect might be link to inflammation and inflammasome activation is a novel concept to contemplate.
Heinrich Schütz und Europa
Creators: name: Leopold, Silke
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Heinrich Schütz wurde im Europa des 20. Jahrhunderts auf vielfältige Art und aus verschiedensten Richtungen vereinnahmt – nichtsdestotrotz sind seine Werke im Gegensatz zu denjenigen beispielsweise Johann Sebastian Bachs in den Konzertsälen auch heute noch eher randständig vertreten und einem engen Kreis von Kennern vertraut. Dies mag auch an Schütz‘ Stellung im sich neu formierenden europäischen Panorama seiner Zeit liegen. Denn Schütz, der sich auch als Opfer der Zeitläufte sah, wollte die eigene Musik von diesen Einflüssen bewusst freihalten.
description: Schütz-Jahrbuch, Bd. 33 (2011)
OAHP Inventory, Building 5018 Firehouse, Camp Bullis, Texas
Creators: name: Walter, Chelsea
Publisher: name: Office of Archaeology and Historic Preservation
Year: 1978
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Building 4168
valueUri: https://core.tdar.org/browse/other-keyword/146652/building-4168
subject: Maintenance Shop
valueUri: https://core.tdar.org/browse/other-keyword/159132/maintenance-shop
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An inventory form by the Office of Archaeology and Historic Preservation for Building 5018 at Camp Bullis, Texas. The structure was built in 1932 as a firehouse.
A Chemical Route to Graphene for Electronics and Spintronics Device Applications
Creators: name: Sarkar, Santanu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The development of selective high precision chemical functionalization strategies for device fabrication, in conjunction with associated techniques for patterning graphene wafers with atomic accuracy would provide the necessary basis for a post-CMOS manufacturing technology. This requires a thorough understanding of the principles governing the reactivity and patterning of graphene at the sub-nanometer length scale. This article reviews our quest to delineate the principles of graphene chemistry - that is, the chemistry at the Dirac point and beyond, and the effect of covalent chemistry on the electronic structure, electrical transport and magnetic properties of this low-dimensional material in order to enable the scalable production of graphene-based devices for low- and high-end technology applications.
description: Please cite this article as: Covalent Chemistry in Graphene Electronics, Materials Today 2012, 15, pp 276 to 285
Memo by Scott Shepherd, Building 675 A Wing, Randolph Air Force Base, Texas
Creators: name: Shepherd, Scott B.
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: A Wing
valueUri: https://core.tdar.org/browse/other-keyword/158942/a-wing
subject: Building 675
valueUri: https://core.tdar.org/browse/other-keyword/146456/building-675
subject: Wing A
valueUri: https://core.tdar.org/browse/other-keyword/158939/wing-a
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A memo written about coordination and correspondence in planning to rehabilitate the doors and windows at Building 675, Randolph Air Force Base, Texas. This letter is part of a group of correspondence and documentation regarding the proposed rehabilitation of Building 675 "A" Wing at Randolph Air Force Base, a property eligible for listing on the National Register of Historic Places. Attachments to these letters include location maps, historic data, undertaking description, and photographs.
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
Creators: name: Schneider, Monika
name: Ye, Zhengmao
name: Zimmermann, Albert G
name: Davis, Beckley K
name: Eitas, Timothy K
name: Roberts, Reid A
name: Holl, Eda K
name: Rahman, Adeeb H
name: Zhang, Lu
name: Allen, Irving C
name: Ting, Jenny P-Y
name: Conti, Brian J
name: Swanson, Karen V
name: Koller, Beverly H
name: Wen, Haitao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Several members of the NLR family of sensors activate innate immunity. In contrast, we found here that NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-κB by interacting with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-κB. We used bioinformatics to predict interactions between NLR and TRAF proteins, including interactions of TRAF with NLRC3. In vivo, macrophage expression of Nlrc3 mRNA was diminished by the administration of lipopolysaccharide (LPS) but was restored when cellular activation subsided. To assess biologic relevance, we generated Nlrc3−/− mice. LPS-treated Nlrc3−/− macrophages had more K63-ubiquitinated TRAF6, nuclear NF-κB and proinflammatory cytokines. Finally, LPS-treated Nlrc3−/− mice had more signs of inflammation. Thus, signaling via NLRC3 and TLR constitutes a negative feedback loop. Furthermore, prevalent NLR-TRAF interactions suggest the formation of a ‘TRAFasome’ complex.
Response from Joseph Logan to Claudia Nissley, Rehabilitation of Building 216, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Department of the Air Force, Randolph Air Force Base
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 216
valueUri: https://core.tdar.org/browse/other-keyword/158228/building-216
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A letter addressing the rehabilitation of Building 216 at Randolph Air Force Base, Texas. The building's interior and exterior features were rehabilitated prior to the completion of the Section 106 process. This correspondence is part of a group of letters and attachments relating to the proposed rehabilitation of Building 216 at Randolph Air Force Base, Texas. Correspondence is between Randolph Air Force Base and the Advisory Council on Historic Preservation and includes location maps, historic data, original floor plans, rehabilitation floor plans, and photographs.
Europa in der ersten Hälfte des 17. Jahrhunderts
Creators: name: Schmidt, Georg
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Im 17. Jahrhundert war „Europa” keine Selbstverständlichkeit – weder geographisch, noch kulturell, noch politisch. Europa war als antiker Mythos, als den anderen überlegener Erdteil oder als Hort der Zivilisation eine intellektuell-künstlerische Abstraktion. Nicht einmal Geographen waren sich darüber einig, wo Europa endete und Asien begann. Schütz‘ eigene „Europaerfahrungen“ sind – ausgehend von seinen Reisewegen und Aufenthaltsorten – begrenzt. Allein der Venedig-Aufenthalt brachte ihn verstärkt mit fremden Lebenswelten in Kontakt und wirkte sich auf sein kompositorisches Schaffen aus.
description: Schütz-Jahrbuch, Bd. 33 (2011)
OAHP Inventory, Building 2001 Hospital Annex, Fort Sam Houston, Texas
Creators: name: Walter, Chelsea
Publisher: name: Office of Archeology and Historic Preservation, Department of the Interior
Year: 1978
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: WWI
valueUri: https://core.tdar.org/browse/temporal-keyword/6372/wwi
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Communal / Public Structure
valueUri: https://core.tdar.org/browse/site-type/314/communal-public-structure
subject: Historic Communal / Public Structure
valueUri: https://core.tdar.org/browse/site-type/316/historic-communal-public-structure
subject: WWI
valueUri: https://core.tdar.org/browse/other-keyword/157760/wwi
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Building 2001
valueUri: https://core.tdar.org/browse/other-keyword/146500/building-2001
subject: World War I
valueUri: https://core.tdar.org/browse/other-keyword/156871/world-war-i
subject: Hospital Complex
valueUri: https://core.tdar.org/browse/other-keyword/159003/hospital-complex
subject: Medical Administration Building
valueUri: https://core.tdar.org/browse/other-keyword/159001/medical-administration-building
subject: Hospital Annex
valueUri: https://core.tdar.org/browse/other-keyword/159002/hospital-annex
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An Office of Archaeology and Historic Preservation inventory form for Building 2001 at Fort Sam Houston, Texas. The structure was built in 1917 as a hospital annex and now serves as a medical administration building.
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
Creators: name: Metzger, Todd
name: Cortez, Jessica T
name: Fan, Una
name: Khan, Imran S
name: Fasano, Kayla
name: Waterfield, Michael
name: Erle, David J
name: Martinez-Llordella, Marc
name: Su, Maureen
name: Pollack, Joshua L
name: Greer, Alexandra
name: Anderson, Mark S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The maintenance of immune tolerance requires the deletion of self-reactive T cells in the thymus. The expression of tissue-specific antigen genes (TSAs) by thymic epithelial cells is critical for this process and depends on the activity of the Autoimmune Regulator (Aire) protein, however, the molecular mechanism(s) Aire uses to target TSA gene loci are unknown. Here we identified two Aire-interacting proteins – activating transcription factor 7 interacting protein (ATF7ip) and methyl CpG binding protein 1 (MBD1) –that are required for Aire’s targeting of TSA geneloci. Moreover, Mbd1−/− mice developed pathological autoimmunity and had a defect in Aire-dependent thymic TSA gene expression underscoring the critical importance of Aire’s interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance.
Reduced-Complexity RF Chain and Antenna Designs for Massive MIMO Transmitters
Creators: Kasem, Ferhad
Publisher: name: University of Alberta Library
Year: 2022

The amount of mobile data handled by wireless broadband cellular networks is increasing explosively.  Multiple-input multiple-output (MIMO) systems have gained a significant importance in modern wireless communication systems. MIMO offers many dimensional advantages that can be utilized to boost capacity and coverage without utilizing more bandwidth or transmit power. The introduction of MIMO systems with large antenna arrays (also known as massive MIMO) and the use of millimeter wave (mmWave) frequency bands are considered some of the key enabling technologies in the 5th generation of cellular systems to satisfy high data rate demands. However, when it comes to hardware implementation, massive MIMO systems with a large number of antennas face some challenges. Each antenna element is driven by a dedicated RF-chain; therefore, the RF-cost increases with the number of antennas. Each RF chain in a MIMO transmitter includes a power amplifier (PA), a mixer

and a digital-to-analog converter (DAC). These components are expensive and power-consuming. Consequently, the cost will increase if the number of antennas grows. Reduced-cost MIMO systems have been drawing attention lately. In this

dissertation, the hardware of a reduced-complexity and cost MIMO transmitter utilizing a single RF chain is presented. The RF chain includes a linear, low-cost, and energy-efficient PA and without the need for a mixer or DAC. This MIMO transmitter can convert digital signals in the baseband to the RF domain. In this MIMO transmitter, antennas are fed by two-port networks called load modulators. Load modulators are diode-based RF circuits that generate the desired outputs. The MIMO transmitter is designed at 3 GHz. The MIMO transmitter is capable of generating 64-QAM constellations at its output ports. This MIMO transmitter is perfectly suitable to operate with current MIMO receivers.
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity
Creators: name: Griffith, Jason W
name: Tai, Melissa
name: Ramirez-Ortiz, Zaida G
name: Hacohen, Nir
name: Luster, Andrew D
name: Cowley, Glenn S
name: Root, David E
name: Pendergraft, William F
name: Means, Terry K
name: Prasad, Amit
name: El Khoury, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The genes and pathways that fine-tune TLR7-mediated innate inflammatory responses remain to be fully elucidated. Using an unbiased genome-scale shRNA screen, we identified the receptor TREML4 as an essential positive regulator of TLR7 signaling. Macrophages from Treml4–/– mice were hyporesponsive to TLR7 agonists and failed to produce type I interferon due to impaired phosphorylation of the transcription factor STAT1 by the MAP kinase p38 and decreased recruitment of MyD88 to TLR7. TREML4 deficiency reduced production of inflammatory cytokines and autoantibodies in SLE-prone MRL/lpr mice and inhibited the antiviral immune response to influenza. Our data identify TREML4 as a positive regulator of TLR7 signaling and provide insight into the molecular mechanisms that control antiviral immunity and the development of autoimmunity.
Music and Lutherian Devotion in the Schütz Era
Creators: name: Frandsen, Mary E.
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: In diesem Beitrag zeichnet die Autorin frühe Erscheinungen von vernakulären Stücken wie Choralbearbeitungen und Spruchmotetten im geistlichen Kontext nach und untersucht deren Beziehung zu lutherischer Pietät sowie ihre Rolle in der geistlichen Musik zur Zeit Heinrich Schütz.
description: Schütz-Jahrbuch, Bd. 33 (2011)
Unexpected power-law stress relaxation of entangled ring polymers
Creators: name: Lang, M.
name: Rubinstein, M.
name: Pyckhout-Hintzen, W.
name: Richter, D.
name: Chang, T.
name: Kapnistos, M.
name: Cho, D.
name: Vlassopoulos, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: After many years of intense research, most aspects of the motion of entangled polymers have been understood. Long linear and branched polymers have a characteristic entanglement plateau and their stress relaxes by chain reptation or branch retraction, respectively. In both mechanisms, the presence of chain ends is essential. But how do entangled polymers without ends relax their stress? Using properly purified high-molar-mass ring polymers, we demonstrate that these materials exhibit self-similar dynamics, yielding a power-law stress relaxation. However, trace amounts of linear chains at a concentration almost two decades below their overlap cause an enhanced mechanical response. An entanglement plateau is recovered at higher concentrations of linear chains. These results constitute an important step towards solving an outstanding problem of polymer science and are useful for manipulating properties of materials ranging from DNA to polycarbonate. They also provide possible directions for tuning the rheology of entangled polymers.
Characterization of phage-host interactions in Stenotrophomonas maltophilia
Creators: McCutcheon, Jaclyn G
Publisher: name: University of Alberta Library
Year: 2022

Bacteriophages are highly abundant viruses that replicate within and effectively kill specific target bacterial hosts. The specificity of phages to their host relies on the presence of the correct cell surface receptor that is recognized by phage receptor binding proteins. These properties make phages desirable as an alternative to antibiotics for the treatment of multidrug resistant bacterial infections, a concept termed phage therapy that has gained renewed interest in recent years. One such bacterium of concern is Stenotrophomonas maltophilia, a Gram-negative opportunistic pathogen that is rapidly increasing in prevalence in hospital and community-acquired infections worldwide, due largely to its numerous innate antibiotic resistance mechanisms. To further develop phage therapy against S. maltophilia and address an overlooked aspect of phage characterization, I have identified the cellular surface receptor for eight S. maltophilia phages. Seven phages with Siphoviridae morphologies adhere to the major pilin subunit of the type IV pilus, a virulence factor that aids in motility, adherence to surfaces and biofilm formation. The eighth phage was identified to putatively interact with the TonB-dependent iron uptake protein, CirA, as a novel phage receptor. To further assess two of these phages as therapeutic candidates, I analyzed their complete genome sequences and phenotypic properties. Phage AXL1 was identified to encode resistance to the frontline antibiotic combination trimethoprim-sulfamethoxazole, whereas AXL3 is a novel virulent phage and candidate for genetic engineering. Additionally, I investigated the lack of in vivo data for S. maltophilia and show that type IV pili-binding phage DLP3 rescues Galleria mellonella larvae from lethal S. maltophilia infection. Further investigation into the mechanism of host interactions for the type IV pili binding phages identified the surface exposed αβ-loop of the major pilin protein as a structural region important for phage binding, as well as two tail proteins in phage DLP2 as putative receptor binding proteins for cross-genera bacterial infection. The identification of bacterial virulence factors as host receptors makes these phages promising candidates for an anti-virulence phage therapy strategy in which phage treatment creates a selective pressure for bacterial avirulence if phage resistant mutants arise.
Nanocapillarity-mediated magnetic assembly of nanoparticles into ultraflexible filaments and reconfigurable networks
Creators: name: Velev, Orlin D.
name: Rubinstein, Michael
name: Bharti, Bhuvnesh
name: Fameau, Anne-Laure
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The fabrication of multifunctional materials with tunable structure and properties requires programmed binding of their building blocks1,2. For example, particles organized in long-ranged structures by external fields3,4 can be bound permanently into stiff chains through electrostatic or van der Waals attraction4,5, or into flexible chains through soft molecular linkers such as surface-grafted DNA or polymers6–11. Here, we show that capillarity-mediated binding between magnetic nanoparticles coated with a liquid lipid shell can be used for the assembly of ultraflexible microfilaments and network structures. These filaments can be magnetically regenerated on mechanical damage, owing to the fluidity of the capillary bridges between nanoparticles and their reversible binding on contact. Nanocapillary forces offer opportunities for assembling dynamically reconfigurable multifunctional materials that could find applications as micromanipulators, microbots with ultrasoft joints, or magnetically self-repairing gels.
Threatened fishes of the world: Craterocephalus fluviatilis McCulloch, 1913 (Atherinidae)
Creators: name: Ebner, Brendan
name: Raadik, Tarmo
name: Ivantsoff, Walter
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

No abstract.
Letter from Joseph Logan to Claudia Nissley, Rehabilitation of Building 216, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Western Office of Project Review, Advisory Council on Historic Preservation
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 216
valueUri: https://core.tdar.org/browse/other-keyword/158228/building-216
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A letter on Section 106 coordination for the rehabilitation of Building 216 at Randolph Air Force Base, Texas. This correspondence is part of a group of letters and attachments relating to the proposed rehabilitation of Building 216 at Randolph Air Force Base, Texas. Correspondence is between Randolph Air Force Base and the Advisory Council on Historic Preservation and includes location maps, historic data, original floor plans, rehabilitation floor plans, and photographs.
Rational points and Galois points for a plane curve over a finite field
Creators: name: Fukasawa, Satoru
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 14H50, 12F10, 14G05

description: We study the relationship between rational points and Galois points for a plane curve over a finite field. It is known that the set of Galois points coincides with that of rational points of the projective plane if the curve is the Hermitian, Klein quartic or Ballico-Hefez curves. We propose a problem: Does the converse hold true? When the curve of genus at most one has a rational point, we will have an affirmative answer.
description: 7 pages
Blueprints, First Floor, Basement, and Research Section, School of Aviation Building 661, Randolph Air Force Base, Texas
Creators: name: Walter, Chelsea
Year: 1993
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: School of Aviation Medicine
valueUri: https://core.tdar.org/browse/other-keyword/153345/school-of-aviation-medicine
subject: Building 661
valueUri: https://core.tdar.org/browse/other-keyword/146442/building-661
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Blueprints of the basement and first floor to be used for the proposed undertaking at Building 661, Randolph Air Force Base, Texas. This letter is part of a group of letters and supporting documentation for the proposed undertaking to rehabilitate the south wing of the first floor and the north wing of the basement at Building 661, Randolph Air Force Base, Texas. The projects focus on the interior of the building that was originally constructed to serve as the installation's School of Aviation Medicine.
Correspondence Packet, Building 235 Self Help, Randolph Air Force Base, Texas
Creators: name: Walter, Chelsea
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Self Help
valueUri: https://core.tdar.org/browse/other-keyword/158929/self-help
subject: Building 235
valueUri: https://core.tdar.org/browse/other-keyword/158252/building-235
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Letters of correspondence regarding small building projects on Randolph Air Force Base, including Building 235. Also mentioned is a need for a survey and a Programmatic Agreement with the state on coordination guidelines, etc.
Unjamming and cell shape in the asthmatic airway epithelium
Creators: name: Kho, Alvin T.
name: Butler, James P.
name: Manning, M. Lisa
name: Israel, Elliot
name: Park, Jin-Ah
name: Tambe, Dhananjay T.
name: Burger, Stephanie
name: Park, Chan Young
name: Weiss, Scott T.
name: Henske, Elizabeth P.
name: McGill, Maureen
name: Shore, Stephanie A.
name: Bi, Dapeng
name: Weitz, David A.
name: Steward Jr, Robert
name: Notbohm, Jacob
name: Tantisira, Kelan
name: Mitchel, Jennifer A.
name: Randell, Scott H.
name: Qazvini, Nader Taheri
name: Hardin, Corey
name: Tschumperlin, Daniel J.
name: Gweon, Bomi
name: Kim, Sae-Hoon
name: Drazen, Jeffrey M.
name: Fredberg, Jeffrey J.
name: Kim, Jae Hun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems— both inert and living—have the potential to jam. The collective can sometimes flow like a fluid or jam and rigidify like a solid. The unjammed-to-jammed transition remains poorly understood, however, and structural properties characterizing these phases remain unknown. Using primary human bronchial epithelial cells, we show that the jamming transition in asthma is linked to cell shape, thus establishing in that system a structural criterion for cell jamming. Surprisingly, the collapse of critical scaling predicts a counter-intuitive relationship between jamming, cell shape and cell–cell adhesive stresses that is borne out by direct experimental observations. Cell shape thus provides a rigorous structural signature for classification and investigation of bronchial epithelial layer jamming in asthma, and potentially in any process in disease or development in which epithelial dynamics play a prominent role.
Transient Behavior of Stochastic Dynamics
Creators: Liu, Shuo
Publisher: name: University of Alberta Library
Year: 2022

This thesis concerns dynamical systems subject to small noise perturbations. Our purpose is to obtain a deep understanding of how small noise perturbations influence the original unperturbed dynamical system, especially over long but finite time intervals. We consider two special systems, the random linear recurrence equation which is a discrete system, and the underdamped Langevin equation which is a continuous system.

According to the classical perturbation theory, small perturbations do not impact much of the dynamics over a short time. When the time tends to infinity, in many situations, the flow can eventually merge with one of the steady states of the perturbed system. As far as we know, small perturbations gradually influence the dynamics in an accumulative way over time, resulting in the so-called transient behavior which describes the process of such a gradual change of dynamics from the unperturbed system to the steady state of the corresponding perturbed system.

We demonstrate this change by utilizing the cut-off phenomenon in the random linear recurrence system. We find the time window when the solution evolves from a deterministic value to the limiting distribution. The underdamped Langevin equation is essentially a slow-fast system admitting three time scales. The unperturbed Hamiltonian system plays a dominant role in the short time scale. In the intermediate time scale, the fast variables have already tended to their stationary distributions and the slow variables transition from their initial deterministic values to the marginal distribution of the slow variables with respect to the system’s stationary distribution. Finally, in the long time scale, all variables are slaved by the stationary distribution.
Putative O-glycosylation Modification Sites of Tsr Are Involved in E. coli Motility
Creators: Vouronikos, Bill Chris
Publisher: name: University of Alberta Library
Year: 2022

Post-translational modifications (PTMs) regulate a variety of normal cellular processes, many of which are conserved across eukaryotes and prokaryotes. One PTM, protein glycosylation with the reversible modification of O-GlcNAc, is well studied in eukaryotes. However, evidence for its existence in prokaryotes remains controversial. Investigating how post-translational modifications work in bacteria will help us understand how bacteria adapt to and survive in changing environments.

Bacterial swarming/swimming motility is mediated by the flagella, but it is the methyl- accepting chemotaxis proteins (MCPs) that control chemotaxis by sensing changes in environmental nutrient and/or waste concentrations. One of the major MCPs in E. coli is Tsr, which has four putative O-GlcNAc modification sites that are directly adjacent to five known methylation sites which are critical for function. Our hypothesis was that the four putative modification sites in Tsr affect bacterial motility. We have shown that two of the four putative modification sites are necessary for motility, as site-directed mutants have significantly reduced motility. We also showed that addition of glucose causes changes in global proteins glycosylation as well as motility. Our work has provided a foundation to investigate the existence of O-GlcNAc in prokaryotes.
Integrin αvβ3 is a coreceptor for human cytomegalovirus
Creators: name: Wang, Xin
name: Huang, David Y
name: Huong, Shu-Mei
name: Huang, Eng-Shang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: HCMV is a widespread opportunistic pathogen that causes birth defects in newborns and severe disease in immunocompromised individuals. The broad tropism of HCMV infection suggests that it utilizes multiple receptors. We recently demonstrated that EGFR serves as a receptor for HCMV. Here we show that HCMV also uses integrin αvβ3 as a coreceptor. Upon infection, HCMV glycoproteins gB and gH independently bind to EGFR and αvβ3, respectively, to initiate viral entry and signaling. αvβ3 then translocates to lipid rafts where it interacts with EGFR to induce coordinated signaling. The coordination between EGFR and αvβ3 is essential for the early events of HCMV infection, including viral entry, RhoA downregulation, stress fiber disassembly, and viral nuclear trafficking. Our findings support a model where EGFR and αvβ3 work together as coreceptors for HCMV entry and signaling. This discovery is fundamental to understanding HCMV pathogenesis and developing treatment strategies targeted to viral receptors.