cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sedimentation of large, soluble proteins up to 140 kDa for 1H-detected MAS NMR and 13C DNP NMR – practical aspects
Creators: name: Bell, Dallas
name: Lindemann, Florian
name: Gerland, Lisa
name: Aucharova, Hanna
name: Klein, Alexander
name: Friedrich, Daniel
name: Hiller, Matthias
name: Grohe, Kristof
name: Meier, Tobias
name: Hughes, Jon
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Protein NMR
subject: Dense phase
subject: Ultracentrifugation
subject: Magic-angle-spinning
subject: Solid-state NMR
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Solution NMR is typically applied to biological systems with molecular weights < 40 kDa whereas magic-angle-spinning (MAS) solid-state NMR traditionally targets very large, oligomeric proteins and complexes exceeding 500 kDa in mass, including fibrils and crystalline protein preparations. Here, we propose that the gap between these size regimes can be filled by the approach presented that enables investigation of large, soluble and fully protonated proteins in the range of 40–140 kDa. As a key step, ultracentrifugation produces a highly concentrated, gel-like state, resembling a dense phase in spontaneous liquid-liquid phase separation (LLPS). By means of three examples, a Sulfolobus acidocaldarius bifurcating electron transfer flavoprotein (SaETF), tryptophan synthases from Salmonella typhimurium (StTS) and their dimeric β-subunits from Pyrococcus furiosus (PfTrpB), we show that such samples yield well-resolved proton-detected 2D and 3D NMR spectra at 100 kHz MAS without heterogeneous broadening, similar to diluted liquids. Herein, we provide practical guidance on centrifugation conditions and tools, sample behavior, and line widths expected. We demonstrate that the observed chemical shifts correspond to those obtained from µM/low mM solutions or crystalline samples, indicating structural integrity. Nitrogen line widths as low as 20–30 Hz are observed. The presented approach is advantageous for proteins or nucleic acids that cannot be deuterated due to the expression system used, or where relevant protons cannot be re-incorporated after expression in deuterated medium, and it circumvents crystallization. Importantly, it allows the use of low-glycerol buffers in dynamic nuclear polarization (DNP) NMR of proteins as demonstrated with the cyanobacterial phytochrome Cph1.
Exponentially tighter bounds on limitations of quantum error mitigation
Creators: name: Quek, Yihui
name: Stilck França, Daniel
name: Khatri, Sumeet
name: Meyer, Johannes Jakob
name: Eisert, Jens
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Computational science
subject: Information theory and computation
subject: Quantum information
subject: Qubits
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Quantum error mitigation has been proposed as a means to combat unwanted and unavoidable errors in near-term quantum computing without the heavy resource overheads required by fault-tolerant schemes. Recently, error mitigation has been successfully applied to reduce noise in near-term applications. In this work, however, we identify strong limitations to the degree to which quantum noise can be effectively ‘undone’ for larger system sizes. Our framework rigorously captures large classes of error-mitigation schemes in use today. By relating error mitigation to a statistical inference problem, we show that even at shallow circuit depths comparable to those of current experiments, a superpolynomial number of samples is needed in the worst case to estimate the expectation values of noiseless observables, the principal task of error mitigation. Notably, our construction implies that scrambling due to noise can kick in at exponentially smaller depths than previously thought. Noise also impacts other near-term applications by constraining kernel estimation in quantum machine learning, causing an earlier emergence of noise-induced barren plateaus in variational quantum algorithms and ruling out exponential quantum speed-ups in estimating expectation values in the presence of noise or preparing the ground state of a Hamiltonian.
RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium’s clinical efficacy
Creators: name: Milanesi, Elena
name: Voinsky, Irena
name: Adva Hadar
name: Srouji, Ala
name: Carlo Maj
name: Shekhtman, Tatyana
name: Gershovits, Michael
name: Gilad, Shlomit
name: Chillotti, Caterina
name: Squassina, Alessio
name: Potash, James B.
name: Schulze, Thomas G.
name: Goes, Fernando S.
name: Zandi, Peter
name: Kelsoe, John R.
name: Gurwitz, David
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome. Methods: RNA sequencing was carried out on 24 LCLs from female BD patients (12 LR and 12 LNR) followed by qPCR validation in two additional independent cohorts (41 and 17 BD patients, respectively). Results: Fifty-six genes showed nominal differential expression comparing LR and LNR (FC ≥ |1.3|, P ≤ 0.01). The differential expression of HDGFRP3 and ID2 was validated by qPCR in the independent cohorts. Conclusions: We observed higher expression levels of HDGFRP3 and ID2 in BD patients who favourably respond to lithium. Both of these genes are involved in neurogenesis, and HDGFRP3 has been suggested to be a neurotrophic factor. Additional studies in larger BD cohorts are needed to confirm the potential of HDGFRP3 and ID2 expression levels in blood cells as tentative favourable lithium response biomarkers.
Electoral violence prevention: what works?
Creators: name: Birch, Sarah
name: Muchlinski, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Elections are in theory democratic means of resolving disputes and making collective decisions, yet too often force is employed to distort the electoral process. The post-Cold War increase in the number of electoral authoritarian and hybrid states has brought this problem into relief. In recent years the prevention of electoral violence has played an increasingly large role in the democratic assistance activities undertaken by international agencies, following increased awareness within the international community of the specific security challenges that elections entail. However, there has to date been little systematic evaluation of the success of different electoral violence prevention (EVP) strategies in reforming electoral institutions so as to enable them to maintain the peace during the electoral period. This article assesses the effectiveness of two common types of international EVP activity. Using a new global dataset of EVP strategies between 2003 and 2015, this article finds evidence that capacity-building strategies reduce violence by non-state actors, whereas attitude-transforming strategies are associated with a reduction in violence by state actors and their allies. The findings are relevant both for understanding the dynamics of electoral violence, and also for policymakers and electoral assistance providers in the international community who have responsibility for the design of democratic assistance projects in states at risk of electoral violence.
Compact Electron Paramagnetic Resonance on a Chip Spectrometer Using a Single Sided Permanent Magnet
Creators: name: Segantini, Michele
name: Marcozzi, Gianluca
name: Elrifai, Tarek
name: Shabratova, Ekaterina
name: Höflich, Katja
name: Deaconeasa, Mihaela
name: Niemann, Volker
name: Pietig, Rainer
name: McPeak, Joseph E.
name: Anders, Jens
name: Naydenov, Boris
name: Lips, Klaus
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: EPR
subject: EPRoC
subject: single side permanentmagnet
subject: spin counting
subject: in situ
subject: in vivo
subject: operando
subject: molecular tumbling
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Electron paramagnetic resonance (EPR) spectroscopy provides information about the physical and chemical properties of materials by detecting paramagnetic states. Conventional EPR measurements are performed in high Q resonator using large electromagnets which limits the available space for operando experiments. Here we present a solution toward a portable EPR sensor based on the combination of the EPR-on-a-Chip (EPRoC) and a single-sided permanent magnet. This device can be placed directly into the sample environment (i.e., catalytic reaction vessels, ultrahigh vacuum deposition chambers, aqueous environments, etc.) to conduct in situ and operando measurements. The EPRoC reported herein is comprised of an array of 14 voltage-controlled oscillator (VCO) coils oscillating at 7 GHz. By using a single grain of crystalline BDPA, EPR measurements at different positions of the magnet with respect to the VCO array were performed. It was possible to create a 2D spatial map of a 1.5 mm × 5 mm region of the magnetic field with 50 μm resolution. This allowed for the determination of the magnetic field intensity and homogeneity, which are found to be 254.69 mT and 700 ppm, respectively. The magnetic field was mapped also along the vertical direction using a thin film a-Si layer. The EPRoC and permanent magnet were combined to form a miniaturized EPR spectrometer to perform experiments on tempol (4-hydroxy-2,2,6,6-teramethylpiperidin-1-oxyl) dissolved in an 80% glycerol and 20% water solution. It was possible to determine the molecular tumbling correlation time and to establish a calibration procedure to quantify the number of spins within the sample.
Constructing policy success for UK energy feedback
Creators: name: Robison, Rosalyn A. V.
name: Foulds, Chris
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Energy-feedback tools are commonly used to promote energy saving. In the UK, energy-feedback provision (currently via an in-home display) is part of the government-mandated roll-out of smart meters to all homes by 2020. A core assumption underlying this widespread provision is that information, or evidence, can lead to positive changes in action. This is analogous to assumptions underlying the notion of ‘evidence-based policy’, and raises questions about how users, researchers and policy-makers go about using evidence when aiming for a ‘successful’ outcome. In addition, the ‘policy feedback’ research agenda has asked how policies alter the landscapes within which they operate by, for example, affecting relationships between actors. Via an in-depth review of Department of Energy and Climate Change (DECC) policy literature over 2010–16, the UK smart meter roll-out was analysed in terms of how its energy-feedback-focused measures may be deemed as ‘successful’. Findings include the fact that direct energy savings played a smaller role than might be expected, and translation from one success measure to another was repeatedly observed. A key conclusion is that acting on feedback requires an assessment of success, but such assessment is highly contextual, for consumers and policy-makers alike. Ways to increase reflexivity in this area are discussed.
When do electoral institutions trigger electoral misconduct?
Creators: name: Ruiz-Rufino, Rubén
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Drawing on two complementary mechanisms, this article explores the question of whether electoral institutions and conditions of electoral competition create incentives to promote electoral misconduct in young or developing democracies. The first mechanism explains how majoritarian institutions like disproportional electoral systems are more likely to trigger electoral fraud than consensus electoral institutions like proportional representation. However, for this mechanism to be activated, the incumbent must feel effectively threatened by the opposition. To better understand the way this mechanism works, the electoral history of the country also needs to be taken into consideration. Democracies which have a historical record of running clean elections are less likely to experience fraud than countries with a history of electoral misconduct. I test these theoretical claims using a dataset that contains relevant information for 323 parliamentary elections in 59 new or developing democracies in the period between 1960 and 2006. The empirical analysis shows a strong and robust empirical support for the two mechanisms.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global Skin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite produced by EUMETSAT (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00097
title: Data Stewardship Maturity Report for GHRSST Level 2P Regional Subskin Sea Surface Temperature from the Tropical Rainfall Mapping Mission (TRMM) Microwave Imager (TMI) for the Atlantic Ocean (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00096
title: Data Stewardship Maturity Report for GHRSST Level 2P Atlantic Regional Skin Sea Surface Temperature from the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) on the Meteosat Second Generation (MSG-2) satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00095
Perceived Peer Integration, Parental Control, and Autonomy Support: Differential Effects on Test Anxiety during the Transition to Secondary School for Girls and Boys
Creators: name: Feige, Paulina
name: Watermann, Rainer
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Test anxiety
subject: School transition
subject: Gender
subject: Peer integration
subject: Parental control
subject: Parental autonomy support
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung

description: Although previous research has investigated the impact of parents and peers on test anxiety in secondary or tertiary education, little is known about younger students, especially during the transition to secondary school. Additionally, it is unclear whether these social factors affect girls’ and boys’ test anxiety differently. Therefore, the current study examined the role of perceived peer integration into the new class context, perceived parental control, and autonomy support on girls’ and boys’ test anxiety (worry and emotionality) during the transition to secondary school. Data from 1770 students (Mage = 10.47, SD = 0.56; 51% females) were analyzed before (4th grade) and after the transition (5th grade) using a multigroup (girls vs. boys) structural equation model. Both facets of test anxiety decreased from 4th to 5th grade. Perceived peer integration into the new class was only relevant for girls’ test anxiety, while parental control predicted post-transition test anxiety for boys. The results suggest that the perceived social environment is an important factor in helping students cope with the demands of the transition to secondary school.
ПРОБЛЕМА И ПРИЧИНЫ МИГРАЦИИ ИЗ ЮЖНОЙ АЗИИ В ЕВРОПУ
Creators: name: Ходиева, Азизахон
Publisher: name: Zenodo
Year: 2024

description: В статье анализируются причины и масштабы миграции населения из стран Южной Азии (Индия, Пакистан, Бангладеш, Шри-Ланка и др.) в европейские страны в последние десятилетия. Основными факторами миграции являются экономические и социальные проблемы в странах исхода: бедность, безработица, перенаселённость, социальное неравенство и политическая нестабильность. В то же время привлекательность европейских стран с точки зрения уровня жизни, занятости, социальных гарантий и личной безопасности стимулирует миграционные потоки, несмотря на ужесточение миграционной политики. В статье анализируются экономические и социальные последствия такой миграции как для принимающих стран, так и для стран исхода мигрантов.
title: Data Stewardship Maturity Report for GHRSST Level 2P Atlantic Regional Skin Sea Surface Temperature from the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) on the Meteosat Second Generation (MSG-1) satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00094
How do national specialty groups develop undergraduate guidelines for medical schools, and which are successful? A systematic review
Creators: name: Whitehouse, Kathrin Joanna
name: Moore, Anne Josephine
name: Cooper, Nicolas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Purpose: To better understand the steps undertaken by medical specialties to develop and implement undergraduate national, and international, educational guidelines for use in medical schools, and to find what makes them successful in terms of uptake and knowledge. Methods: Systematic review of databases to find inter- and nationally-created undergraduate medical specialty guidelines, and descriptions of development and analysis, from 1998 to January 2015. Results: Ninety six eligible papers were found, covering 59 different guidelines in 32 specialties. Five documented from development to revision. Development often required multiple stages and methods, 10 using the Delphi technique. Twenty two guidelines mapped to recommended government standards. Twenty papers analyzed curricula. No guideline was used in every relevant medical school. Conclusions: This is a comprehensive review of the processes involved in creating international and national guidelines, with emphasis of key points for those considering similar undertakings. These include thorough needs analysis of multiple groups involved in the delivery of the curriculum; and engagement of relevant parties throughout development, to ensure relevance and increase buy-in. Flexibility is important, to allow use in medical schools with different methods of teaching. Ongoing evaluation and update are also critical steps that must not be forgotten.
title: Data Stewardship Maturity Report for GHRSST Level 3C America Regional Subskin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES) Imager on the GOES-13 satellite (GDS version 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00093
STEAM YONDASHUVLARI VA AQLLI TA'LIM TEXNOLOGIYALARI.
Creators: name: Tayirova, Sarvinoz
name: Tangriyeva, Dilovar
Publisher: name: Zenodo
Year: 2024

description: Maqolada STEAM ta'limi tushunchasi haqida so'z boradi. STEAM "fiziklar" va "liriklar" o'rtasidagi uzluksiz tortishuvni bartaraf qiladi, chunki uning doirasida lirik muhandislik (ixtiro) va fizik dizayn kabi estetik, badiiy ko'rinishlarda iste'dodli bo'lishi mumkin. Badiiy matnni tahlil qilishda o'quv STEAM mahsuloti birinchi navbatda o'quvchilarning ijodiy salohiyatining namoyon bo'lishi sifatida dizayn echimiga yo'naltirilgan. STEAM ta'limi - ilmiy va xayoliy, hujjatli va estetik, badiiy va ratsional tamoyillarni o'zida mujassam etgan yangi integratsion ta'lim tizimi.
A Danish adaptation of the Boston Naming Test: preliminary norms for older adults and validity in mild Alzheimer’s disease
Creators: name: Jørgensen, Kasper
name: Johannsen, Peter
name: Vogel, Asmus
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: The purpose of the present study was to develop a Danish adaptation of the Boston Naming Test (BNT) including a shortened 30-item version of the BNT for routine clinical use and two parallel 15-item versions for screening purposes. Method: The Danish adaptation of the BNT was based on ranking of items according to difficulty in a sample of older non-patients (n = 99). By selecting those items with the largest discrepancy in difficulty for non-patients compared to a mild Alzheimer’s disease (AD) sample (n = 53), the shortened versions of the BNT were developed. Using an overlapping cells approach preliminary education and age norms for older Danes were constructed. Results: The Danish adaptation of the BNT had adequate reliability and the short versions were all highly correlated with the full 60-item BNT (BNT-60). The sensitivity and specificity of the BNT-60 was .83 and .86, respectively. The shortened versions displayed some reduction in sensitivity (.70–.77) but similar or better specificity (.86–.91). Post-test probabilities of mild AD associated with performances along selected score ranges of the BNT were estimated. Likelihood ratios were presented that can be combined with information regarding the base rate of AD in any setting in order to assist in interpreting the clinical significance of a given performance. Conclusion: The short Danish versions of the BNT were highly correlated with the full BNT indicating that they measure the same construct. The Danish versions had acceptable diagnostic accuracy discriminating between mild AD and older non-patients.
title: Data Stewardship Maturity Report for GHRSST 2 Level 2P Global Skin Sea Surface Temperature from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi NPP satellite created by the NOAA Advanced Clear-Sky Processor for Ocean (ACSPO) (GDS version 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00092
An exploration of the accentuation effect: errors in memory for voice fundamental frequency (F0) and speech rate
Creators: name: Gous, Georgina
name: Dunn, Andrew K.
name: Baguley, Thom
name: Stacey, Paula C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: The accentuation effect demonstrates how memory often reflects category typical representations rather than the specific features of learned items. The present study investigated the impact of manipulating fundamental frequency (F0) and speech rate (syllables per second) on immediate target matching performance (selecting a voice from a pair to match a previously heard target voice) for a range of synthesised voices. It was predicted that when participants were presented with high or low frequency target voices, voices even higher or lower in frequency would be selected. The same pattern was also predicted for speech rate. Inconsistent with the accentuation account, the results showed a general bias to select voices higher in frequency for high, moderate, and low frequency target voices. For speech rate, listeners selected voices faster in rate for slow rate target voices. Overall it seems doubtful that listeners rely solely on categorical information about voices during recognition.
title: Data Stewardship Maturity Report for GHRSST Level 2P Central Pacific Regional Skin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES) Imager on the GOES-15 satellite (GDS versions 1 and 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00091
title: Data Stewardship Maturity Report for GHRSST Level 2P Western Atlantic Regional Skin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES) Imager on the GOES-13 satellite (GDS versions 1 and 2)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00090
RNA-sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium’s clinical efficacy
Creators: name: Milanesi, Elena
name: Voinsky, Irena
name: Adva Hadar
name: Srouji, Ala
name: Carlo Maj
name: Shekhtman, Tatyana
name: Gershovits, Michael
name: Gilad, Shlomit
name: Chillotti, Caterina
name: Squassina, Alessio
name: Potash, James B.
name: Schulze, Thomas G.
name: Goes, Fernando
name: Zandi, Peter
name: Kelsoe, John R.
name: Gurwitz, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: OBJECTIVES: Lithium remains the oldest and most effective treatment for mood stabilization in bipolar disorder (BD) even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA-sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium responsive (LR) vs. lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome. METHODS: RNA-sequencing was carried out on 24 LCLs from female BD patients (12 LR and 12 LNR) followed by qPCR validation in two additional independent cohorts (41 and 17 BD patients, respectively). RESULTS: Fifty-six genes showed nominal differential expression comparing LR and LNR (FC≥|1.3|, p≤0.01). The differential expression of HDGFRP3 and ID2 was validated by qPCR in the independent cohorts. CONCLUSIONS: We observed higher expression levels of HDGFRP3 and ID2 in BD patients who favorably respond to lithium. Both of these genes are involved in neurogenesis and HDGFRP3 has been suggested to be a neurotrophic factor. Additional studies in larger BD cohorts are needed to confirm the potential of HDGFRP3 and ID2 expression levels in blood cells as tentative favorable lithium response biomarkers.
Missense mutations of NCPAG gene affect calving ease in Piedmontese cattle: preliminary evidences
Creators: name: Chillemi, Giovanni
name: Bongiorni, Silvia
name: Gioiosa, Silvia
name: Flati, Tiziano
name: Castrignanò, Tiziana
name: Milanesi, Marco
name: Marsan, Paolo Ajmone
name: Valentini, Alessio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: A previous genome scan on 323 Piedmontese individuals identified a cluster of 13 SNPs significantly associated with direct calving ease and centred on the three genes LAP3, LCORL and NCAPG in chromosome 6. We investigated missense mutations affecting calving ease in Piedmontese cattle in the identified region using sequences from the whole exome in eight Piedmontese individuals chosen from the extremes of the direct calving ease estimated breeding values distribution for this trait. The present study has not found missense variants in LAP3 and LCORL, while two were identified on NCAPG by three different variant calling methods. Other gene candidates in the same region harbour missense mutations, such as PPM1K, PKD2, SPP1 and MEPE, but both SIFT analysis and chi-square test on frequency of alleles make us hypothesise that NCAPG is the single gene responsible for the trait variation. The two SNPs on NCAPG are in complete linkage disequilibrium in our samples; therefore, further investigations are needed in order to discriminate their role.
title: Data Stewardship Maturity Report for GHRSST Level 2P Eastern Pacific Regional Skin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES) Imager on the GOES-11 satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00089
DIE ROLLE DER NONVERBALEN KOMMUNIKATION IM "DAF"-UNTERRICHT (DEUTSCH ALS FREMDSPRACHE).
Creators: name: Tayirova, Sarvinoz
name: Tangriyeva, Dilovar
Publisher: name: Zenodo
Year: 2024

description: Der Artikel diskutiert die Möglichkeiten, nonverbale Kommuni kationsmethoden einzusetzen, um die Effektivität des Unterrichts in DaF-Klassen zu steigern. Die Meinungen westlicher Wissenschaftler zu diesem Thema wurden untersucht und Schlussfolgerungen über die Vorteile des  Einsatzes nonverbaler Kommunikation im Lehrprozess gezogen.
Enhancing adipose stem cell chondrogenesis: A study on the roles of dexamethasone, transforming growth factor β3 and ascorbate supplements and their combination
Creators: name: Arshan Nazempour
name: Quisenberry, Chrystal R
name: Abu-Lail, Nehal I
name: Wie, Bernard J Van
Publisher: name: figshare
Year: 2017
Subjects: subject: Stem Cells
subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology

description: Varied exogenous chondrogenic factors (CFs) are implicated in promoting differentiation of stem cells along a chondrocyte lineage in the field of regenerative tissue engineering for articular cartilage repair. The effects of dexamethasone, transforming growth factor β3 (TGF-β3), ascorbate, and their combinations, on mRNA expression in micromass-cultured human adipose derived stem cells (hADSCs) were investigated as a function of time. Indices include chondrogenic, hypertrophic, angiogenic, fibrogenic and osteogenic markers along with mechanical properties, assessed by atomic force microscopy. Early in the culture, i.e., at day three, no significant differences in mRNA expression of SOX9, aggrecan, lubricin, Col XI, Col X, vascular endothelial growth factor, Col I, and alkaline phosphatase were observed among samples treated with different CFs. However, significant differences in mRNA expression levels of pre-mentioned markers among samples treated with each CF exist when samples were supplied with the CFs for more than three days. A new indexing scheme summing expression of chondrogenic and subtracting non-chondrogenic angiogenic, fibrogenic and osteogenic marker levels shows dexamethasone is the overall leading CF among the factors and their combinations. Based on this scheme, we have projected not only the possible signaling pathways which might be affected by addition of CFs but also hypothetical indexes that may occur upon temporal variation of growth factor regimens.
title: Data Stewardship Maturity Report for GHRSST Level 2P Regional 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NAVO (GDS versions 1 and 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00088
title: Data Stewardship Maturity Report for GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NEODAAS (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00087
Additional file 1 of Effectiveness of bevacizumab in the treatment of metastatic colorectal cancer: a systematic review and meta-analysis
Creators: name: Song, Yu
name: Mao, Qianqian
name: Zhou, Manling
name: Liu, Cheng-Jiang
name: Kong, Li
name: Hu, Ting
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Biotechnology
Cancer
Science Policy

description: Supplementary Material 1
title: ADCO, Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Cart. 29 (G 134), 996 folios, f. 0650
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0650, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0650, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
title: Data Stewardship Maturity Report for GHRSST v2 Level 3U Global Skin Sea Surface Temperature from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi NPP satellite created by the NOAA Advanced Clear-Sky Processor for Ocean (ACSPO) (GDS version 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00086
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00566
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: comptes

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00566, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: Data Stewardship Maturity Report for GHRSST Level 2P West Atlantic Regional Skin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES) Imager on the GOES-12 satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00085
Additional file 1 of Association between drinking water quality and mental health and the modifying role of diet: a prospective cohort study
Creators: name: Zhou, Shuduo
name: Su, Mintao
name: Shen, Peng
name: Yang, Zongming
name: Chai, Pengfei
name: Sun, Shengzhi
name: Lin, Hongbo
name: Shui, Liming
name: Zhang, Na
name: Xu, Ming
name: Zheng, Zhi-Jie
name: Wang, Jianbing
name: Zhang, Zhenyu
name: Chen, Kun
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1: Table S1. Baseline characteristics of study participants stratified by the levels of Manganese in tap water. Table S2. Baseline characteristics of study participants stratified by the levels of Zinc in tap water. Table S3. Baseline characteristics of study participants stratified by the levels of Copper in tap water. Table S4. Baseline characteristics of study participants stratified by the levels of Iron in tap water. Table S5. Baseline characteristics of study participants stratified by the levels of Aluminum in tap water. Table S6. Baseline characteristics of study participants stratified by the levels of Cadmium in tap water. Table S7. Baseline characteristics of study participants stratified by the levels of Selenium in tap water. Table S8. Baseline characteristics of study participants stratified by the levels of Fluorine in tap water. Table S9. Subgroup analysis for the prospective association between metal, nonmetal elements exposure and onset of depression. Table S10. Subgroup analysis for the prospective association between metal, nonmetal elements exposure and onset of anxiety. Table S11. Sensitive analysis of association between long term exposure to metal and nonmetal elements and risk of depression and anxiety onset. Table S12. E-value for point estimates and the lower 95% confidence intervals of the Hazard. Fig. S1. Directed acyclic graph for water exposure and depression, anxiety.
Integrating the small side games in the training programs during the preparation period and their role in developing the physical performance of the footballers "study from the perspective of the coaches"
Creators: name: Housseyni, CISSE
name: Nabila, MIMOUNI-TOUABTI
name: TOUABTI, Souhem Laldja
Publisher: name: Zenodo
Year: 2024
Subjects: malian pupils, morphotyypology parametrs, growth

description: The aim of this work is the study of height and weight development in students aged 6 to 12 schooled in Mali, capital Bamako. and determining the growth status of that population. Means and Methods; 300 students aged 6 to 12 took part in this study. divided into 2 age categories 6-8 years, 9-12 years. Anthropometric measurements were carried out using standardized and verified instruments, as well as weight, height, BMI (body mass index) for determining the state of corpulence, and some indices of physical development. The weight growth in boys evolve in favor of children from the age of 9-10 years. While in girls, the weight isgreater at 11-12 years (t-test p<0.01), Concerning the stature, no significant difference was recordedbetween the two age groups although this parameter knows a significant acceleration from the age of 10,which is confirmed by the literature. Conclusion: Somatic growth is in linear progression in both sexes. Concerning the weight, the boys are increasingly heavy ((t-test p<0.001) while in girls, the difference is significant ((t-test p<0.01). These results invite us to investigate encompassing a broader assessment related to growth and diet through a longitudinal study that could be compared with WHO international benchmark
Morphotypology of Malian children aged 9-12 years old
Creators: name: Housseyni, CISSE
name: Nabila, MIMOUNI-TOUABTI
name: TOUABTI, Souhem Laldja
Publisher: name: Zenodo
Year: 2024
Subjects: malian pupils, morphotyypology parametrs, growth

description: The aim of this work is the study of height and weight development in students aged 6 to 12 schooled in Mali, capital Bamako. and determining the growth status of that population. Means and Methods; 300 students aged 6 to 12 took part in this study. divided into 2 age categories 6-8 years, 9-12 years. Anthropometric measurements were carried out using standardized and verified instruments, as well as weight, height, BMI (body mass index) for determining the state of corpulence, and some indices of physical development. The weight growth in boys evolve in favor of children from the age of 9-10 years. While in girls, the weight isgreater at 11-12 years (t-test p<0.01), Concerning the stature, no significant difference was recordedbetween the two age groups although this parameter knows a significant acceleration from the age of 10,which is confirmed by the literature. Conclusion: Somatic growth is in linear progression in both sexes. Concerning the weight, the boys are increasingly heavy ((t-test p<0.001) while in girls, the difference is significant ((t-test p<0.01). These results invite us to investigate encompassing a broader assessment related to growth and diet through a longitudinal study that could be compared with WHO international benchmark
An efficient method for identifying natural common homoisoflavonoid by 1H-NMR
Creators: name: Ning, Zun-Xi
name: Zhang, Xin-Xin
name: Li, Wei
name: Liu, Xin-Yu
name: Wei, Xiu-Yan
name: Gao, Hui-Yuan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Homoisoflavone contains 16 carbon atoms in the skeleton. The homoisoflavonoid skeleton from natural products can be roughly divided into 13 kinds, among which 5 kinds of common skeletons contain a large amount of compounds and 8 kinds of abnormal skeletons comprise a small amount of compounds. In this article, the structure identification experience of homoisoflavonoids found in Caesalpinia mimosoides was used as references and an efficient 1H NMR spectroscopic method for identifying homoisoflavonoid structure has been established. Using the chemical shift differences of H-2, 3, 4 and 9, the common natural homoisoflavonoids can be quickly and conveniently determined.
title: ADCO, Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Cart. 178 (11 H 80), 82 folios, f. 0168
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 178 (11 H 80), 82 folios, f. 0168, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 178 (11 H 80), 82 folios, f. 0168, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium’s clinical efficacy
Creators: name: Milanesi, Elena
name: Voinsky, Irena
name: Adva Hadar
name: Srouji, Ala
name: Carlo Maj
name: Shekhtman, Tatyana
name: Gershovits, Michael
name: Gilad, Shlomit
name: Chillotti, Caterina
name: Squassina, Alessio
name: Potash, James B.
name: Schulze, Thomas G.
name: Goes, Fernando S.
name: Zandi, Peter
name: Kelsoe, John R.
name: Gurwitz, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome. Methods: RNA sequencing was carried out on 24 LCLs from female BD patients (12 LR and 12 LNR) followed by qPCR validation in two additional independent cohorts (41 and 17 BD patients, respectively). Results: Fifty-six genes showed nominal differential expression comparing LR and LNR (FC ≥ |1.3|, P ≤ 0.01). The differential expression of HDGFRP3 and ID2 was validated by qPCR in the independent cohorts. Conclusions: We observed higher expression levels of HDGFRP3 and ID2 in BD patients who favourably respond to lithium. Both of these genes are involved in neurogenesis, and HDGFRP3 has been suggested to be a neurotrophic factor. Additional studies in larger BD cohorts are needed to confirm the potential of HDGFRP3 and ID2 expression levels in blood cells as tentative favourable lithium response biomarkers.