cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Responsiveness for mouse IgG2b antibodies to the human alpha/beta T-cell receptor/CD3 complex: evidence for genetic determination and low grade antibody cross-linking not mediated by known Fc gamma receptors
Creators: name: Schlitt, Hans-Jürgen
name: Schwinzer, R.
name: Wonigeit, K.
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 610 Medizin
subject: Animals
subject: Antibodies, Monoclonal/immunology
subject: Antigen-Antibody Reactions
subject: Antigen-Presenting Cells/immunology
subject: Antigens, CD3/immunology
subject: Humans
subject: Immunoglobulin G/immunology
subject: Immunoglobulin Isotypes/immunology
subject: Mice
subject: Pedigree
subject: Receptors, Antigen, T-Cell, alpha-beta/immunology
subject: Receptors, Fc/immunology

description: Mouse IgG2a and IgG3 antibodies directed to the human T-cell receptor/CD3 complex stimulate peripheral blood mononuclear cells in almost all individuals. By contrast, responder and non-responder individuals exist for the stimulatory effect of mouse IgG1 and IgG2b antibodies. Whereas responsiveness to IgG1 antibodies is rather frequent (60-70%) and is known to be determined by an Fc gamma RII polymorphism on the accessory cells, little is known about the underlying factors of the rare (6%) IgG2b responsiveness. In this study it is shown that (1) IgG2b responsiveness is genetically determined with a dominant pattern of inheritance; (2) IgG2b responsiveness is determined by a radioresistant feature of responder accessory cells which can be substituted by artificial cross-linking, but not by IL-1 beta or IL-2; (3) stimulation of peripheral blood mononuclear cells of an IgG2b responder by IgG2b antibodies requires rather high antibody concentration compared with stimulation by IgG2a antibodies; (4) the stimulation leads to proliferation and IL-2 receptor expression, but no measurable IL-2 production; (5) antibody binding to known Fc gamma receptors (Fc gamma RI, Fc gamma RII, Fc gamma RIII) is not involved in the stimulatory effect of the IgG2b antibodies in responders. These results demonstrate that responsiveness to IgG2b antibodies against the TcR/CD3 complex depends on a genetically determined feature of accessory cells that is not identical with any of the known Fc gamma receptors. Most likely, the stimulatory effect observed in IgG2b responders is explained by a low grade cross-linking of the antibody by a not yet identified polymorphic structure on the surface of accessory cells.
Human Gene Editing and the Ethics of Enhancement
Creators: name: Juengst, Eric
Publisher: name: Center for ELSI Resources and Analysis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ethics
subject: Science
subject: ELSI
subject: genetic enhancement
subject: human genome editing governance
subject: eugenics
subject: health equity

description: Although polygenic prediction of highly complex educational traits and outcomes—which are known to be strongly influenced by social and environmental factors—are extremely limited in predictive accuracy, high profile research scientists have already begun to entertain potential applications in educational settings. Perhaps the most sensational among these has been Robert Plomin’s call for “precision education,” in which he suggests that technology will soon be able “to use DNA ‘chips’ to predict strengths and weaknesses for individual pupils and to use this information to put personalized strategies in place for them” (See Asbury and Plomin, 2014 below). Think of a child’s individualized education plan (IEP), only with the inclusion of PGS for math and reading ability. Proponents of potential applications of polygenic prediction in educational settings suggest genetic tests could be used to identify children who are likely to struggle in specific areas so that they can be delivered educational interventions to help “lift them up.”
Discovery of millisecond pulsars in radio searches of southern Fermi LAT sources
Creators: name: Keith, M. J.
name: Johnston, S.
name: Ray, P. S.
name: Ferrara, E. C.
name: Parkinson, P. M. Saz
name: Celik, O.
name: Belfiore, A.
name: Donato, D.
name: Cheung, C. C.
name: Abdo, A. A.
name: Camilo, F.
name: Freire, P. C. C.
name: Guillemot, L.
name: Harding, A. K.
name: Kramer, M.
name: Michelson, P. F.
name: Ransom, S. M.
name: Romani, R. W.
name: Smith, D. A.
name: Thompson, D. J.
name: Weltevrede, P.
name: Wood, K. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using the Parkes radio telescope we have carried out deep observations of eleven unassociated gamma-ray sources. Periodicity searches of these data have discovered two millisecond pulsars, PSR J1103-5403 (1FGL J1103.9-5355) and PSR J2241-5236 (1FGL J2241.9-5236), and a long period pulsar, PSR J1604-44 (1FGL J1604.7-4443). In addition we searched for but did not detect any radio pulsations from six gammaray pulsars discovered by the Fermi satellite to a level of - 0.04 mJy (for pulsars with a 10% duty cycle). Timing of the millisecond pulsar PSR J1103-5403 has shown that its position is 9' from the centroid of the gamma-ray source. Since these observations were carried out, independent evidence has shown that 1FGL J1103.9-5355 is associated with the flat spectrum radio source PKS 1101-536. It appears certain that the pulsar is not associated with the gamma-ray source, despite the seemingly low probability of a chance detection of a radio millisecond pulsar. We consider that PSR J1604-44 is a chance discovery of a weak, long period pulsar and is unlikely to be associated with 1FGL J1604.7-4443. PSR J2241-5236 has a spin period of 2.2 ms and orbits a very low mass companion with a 3.5 hour orbital period. The relatively high flux density and low dispersion measure of PSR J2241-5236 makes it an excellent candidate for high precision timing experiments. The gamma-rays of 1FGL J2241.9-5236 have a spectrum that is well modelled by a power law with exponential cutoff, and phasebinning with the radio ephemeris results in a multi-peaked gamma-ray pulse profile. Observations with Chandra have identified a coincident X-ray source within 0.1" of the position of the pulsar obtained by radio timing
description: 9 Pages 6 Figures, for publication in MNRAS
Evolution of the Chandra CCD Spectra of SNR 1987A: Probing the Reflected-Shock Picture
Creators: name: Zhekov, Svetozar A.
name: Park, Sangwook
name: McCray, Richard
name: Racusin, Judith L.
name: Burrows, David N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We continue to explore the validity of the reflected shock structure (RSS) picture in SNR 1987A that was proposed in our previous analyses of the X-ray emission from this object. We used an improved version of our RSS model in a global analysis of 14 CCD spectra from the monitoring program with Chandra. In the framework of the RSS picture, we are able to match both the expansion velocity curve deduced from the analysis of the X-ray images and light curve. Using a simplified analysis, we also show that the X-rays and the non-thermal radio emission may originate from the same shock structure (the blast wave). We believe that using the RSS model in the analysis of grating data from the Chandra monitoring program of SNR 1987A that cover a long enough time interval, will allow us to build a more realistic physical picture and model of SNR 1987A.
description: 14 pages, 1 Table, 8 figures, accepted for publication in MNRAS
Evolution of hydrothermal alteration and mineralization at the deformed Kerr and Deep Kerr Cu-Au porphyry deposits, northwestern British Columbia, Canada
Creators: name: Rosset, Sandra
Publisher: name: University of British Columbia
Year: 2018

description: The calc-alkalic Kerr and Deep Kerr Cu-Au porphyry deposits are located in northwestern British Columbia, and are part of the Kerr-Sulphurets-Mitchell (KSM) property. The deposits comprise a steeply dipping tabular intrusive complex extending N-S ~2.4 km, with a vertical extent >2 km. Ore is primarily hosted within syn-mineral intrusions of monzonite (~197 Ma: Bridge, 1993) which intruded volcanosedimentary rocks of the Hazelton group. The Kerr deposit contains probable reserves of 276 million tonnes at 0.43% Cu, and 0.22g/t Au, for a contained total of 2.6 billion lb’s Cu, and 2.0 million oz’s Au (Seabridge Gold, 2016). The Deep Kerr deposit has an inferred resource estimate of 1.92 billion tonnes grading 0.41% Cu and 0.31 g/t Au for a contained total of 17.3 billion lb’s Cu, and 19.1 million oz’s Au (Seabridge Gold, 2017). Hydrothermal alteration assemblages are zoned, from early high-temperature potassic alteration located centrally at depth, outwards into subsequent dark chlorite-sericite and sericite-chlorite alteration assemblages. The upper ~1.5 km of the deposit is largely overprinted by late phyllic alteration. Potassic alteration was initially more extensive, and has been largely overprinted. The vein paragenesis comprises ten main vein types subdivided into syn-mineral and late- to post-mineral veins. Copper and gold mineralization are primarily associated with A and B type quartz-sulphide veins contemporaneous with potassic alteration. High-grade copper and gold mineralization is correlated with quartz vein abundance above 500 m elevation within the deposit, and is of a more disseminated style below this elevation. Phyllic alteration introduces molybdenum. A hydrothermal zonation in both white micas and chlorites was indicated with short-wave infrared spectroscopy. White mica composition becomes more Fe+Mg rich (phengitic) distally from the hydrothermal centre, and is also more phengitic at depth within potassic and dark chlorite-sericite altered rocks. The Mg content of chlorites relative to Fe increases with increasing proximity to the centre of the hydrothermal plume. A zonation in sulphides and suphates was indicated by sulphur isotope analysis. Sulphides are isotopically lighter (lower δ³⁴S values) proximal to the high-grade core of the deposit, and sulphates become isotopically heavier (increasing δ³⁴S values) with decreasing depth in the hydrothermal system.
Gilbert Damping in Single and Multilayer Ultrathin Films: Role of Interfaces in Nonlocal Spin Dynamics
Creators: name: Urban, R.
name: Woltersdorf, Georg
name: Heinrich, B.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: 530 Physik

description: Unique features of the Gilbert damping in magnetic multilayers were investigated by ferromagnetic resonance (FMR) using magnetic single and double layer structures prepared by molecular beam epitaxy. The FMR linewidth for the Fe films in the double layer structures was larger than the FMR linewidth in the single Fe films having the same thickness. The additional FMR linewidth scaled inversely with the film thickness, and increased linearly with increasing microwave frequency. These results demonstrate that a transfer of electron angular momentum between the magnetic layers leads to additional relaxation torques.
The Diffeomorphism Constraint Operator in Loop Quantum Gravity
Creators: name: Laddha, Alok
name: Varadarajan, Madhavan
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct the smeared diffeomorphism constraint operator at finite triangulation from the basic holonomy- flux operators of Loop Quantum Gravity, evaluate its continuum limit on the Lewandowski- Marolf habitat and show that the action of the continuum operator provides an anomaly free representation of the Lie algebra of diffeomorphisms of the 3- manifold. Key features of our analysis include: (i) finite triangulation approximants to the curvature, $F_{ab}^i$ of the Ashtekar- Barbero connection which involve not only small loop holonomies but also small surface fluxes as well as an explicit dependence on the edge labels of the spin network being acted on (ii) the dependence of the small loop underlying the holonomy on both the direction and magnitude of the shift vector field (iii) continuum constraint operators which do {\em not} have finite action on the kinematic Hilbert space, thus implementing a key lesson from recent studies of parameterised field theory by the authors. Features (i) and (ii) provide the first hints in LQG of a conceptual similarity with the so called "mu- bar" scheme of Loop Quantum Cosmology. We expect our work to be of use in the construction of an anomaly free quantum dynamics for LQG.
description: 37 pages, 6 figures
The targum (1879:June)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1879

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Posttraumatisches akutes Lungenversagen: Behandlung durch drucklimitierte Beatmung und kontinuierlichen Lagewechsel [Acute posttraumatic lung failure. Its treatment through pressure-limited respiration and continuous postural change]
Creators: name: Schlitt, Hans-Jürgen
name: Werner, U.
name: Schandelmaier, P.
name: Krettek, C.
name: Dreinhöfer, K.
name: Hauss, J.
name: Pichlmayr, R.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Adult
subject: Beds
subject: Combined Modality Therapy
subject: Female
subject: Humans
subject: Lung Compliance
subject: Male
subject: Middle Aged
subject: Positive-Pressure Respiration/methods
subject: Posture
subject: Prognosis
subject: Respiratory Distress Syndrome, Adult/therapy
subject: Time Factors
subject: Wounds and Injuries/complications

description: Nine patients (4 women and 5 men; mean age 31 [20-48] years) with severe posttraumatic adult respiratory distress syndrome (ARDS) were treated with continuous postural change (kinetic bed) and pressure-limited ventilation. Seven patients survived; only one patient died as a result of pulmonary insufficiency. As compliance was markedly reduced (less than 20 ml/cm H2O), low stroke volumes (up to 380 ml) and high respiratory rate (up to 45/min) were employed to keep airway peak pressure below 40 mmHg. Kinetic treatment lasted for a mean of 14 (2-28) days; artificial ventilation was maintained for 31 (9-49) days. Practical problems of the method are the intensive nursing care required for the kinetic bed and the risk of decubitus ulcers, as well as disconnection of infusion tubing. The results indicate that kinetic treatment with pressure-limited ventilation constitutes a low-risk and, in many cases, effective treatment of severe ARDS.
Characterization of Immunoglobulin Repertoires after Vaccination in OmniRatTM and Monoclonal CD5+ B Cell Expansion in A20BKOsCYLDBOE Mice using an Ion Torrent PGM High-Throughput Sequencing Platform
Creators: name: Bürckert, Jean-Philippe
Publisher: name: Trier University
Year: 2018
Subjects: subject: Immunsystem
subject: Immunoglobuline
subject: Repertoire
subject: Sequenzanalyse
subject: Messenger-RNS
subject: Tiermodell
subject: immune system
subject: sequential analysis
subject: animal model

description: With the advent of high­throughput sequencing (HTS), profiling immunoglobulin (IG) repertoires has become an essential part of immunological research. The dissection of IG repertoires promises to transform our understanding of the adaptive immune system dynamics. Advances in sequencing technology now also allow the use of the Ion Torrent Personal Genome Machine (PGM) to cover the full length of IG mRNA transcripts. The applications of this bench­top scale HTS platform range from identification of new therapeutic antibodies to the deconvolution of malignant B cell tumors. In the context of this thesis, the usability of the PGM is assessed to investigate the IG heavy chain (IGH) repertoires of animal models. First, an innovate bioinformatics approach is presented to identify antigendriven IGH sequences from bulk sequenced bone marrow samples of transgenic humanized rats, expressing a human IG repertoire (OmniRatTM). We show, that these rats mount a convergent IGH CDR3 response towards measles virus hemagglutinin protein and tetanus toxoid, with high similarity to human counterparts. In the future, databases could contain all IGH CDR3 sequences with known specificity to mine IG repertoire datasets for past antigen exposures, ultimately reconstructing the immunological history of an individual. Second, a unique molecular identifier (UID) based HTS approach and network property analysis is used to characterize the CLL­like CD5+ B cell expansion of A20BKO mice overexpressing a natural short splice variant of the CYLD gene (A20BKOsCYLDBOE). We could determine, that in these mice, overexpression of sCYLD leads to unmutated subvariant of CLL (U­CLL). Furthermore, we found that this short splice variant is also seen in human CLL patients highlighting it as important target for future investigations. Third, the UID based HTS approach is improved by adapting it to the PGM sequencing technology and applying a custom­made data processing pipeline including the ImMunoGeneTics (IMGT) database error detection. Like this, we were able to obtain correct IGH sequences with over 99.5% confidence and correct CDR3 sequences with over 99.9% confidence. Taken together, the results, protocols and sample processing strategies described in this thesis will improve the usability of animal models and the Ion Torrent PGM HTS platform in the field if IG repertoire research.
Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function
Creators: name: Bleck, J. S.
name: Schlitt, Hans-Jürgen
name: Christians, U.
name: Schottmann, R.
name: Thiesemann, C.
name: Strohmeyer, S.
name: Kohlhaw, K.
name: Wonigeit, K.
name: Pichlmayr, R.
name: Sewing, K. F.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: Ciclosporin; metabolism; metabolites; liver dysfunction; kidney transplantation
subject: 610 Medizin
subject: Alanine Transaminase/blood
subject: Alkaline Phosphatase/blood
subject: Aspartate Aminotransferases/blood
subject: Bilirubin/blood
subject: Cholestasis/metabolism
subject: Cholinesterases/blood
subject: Creatinine/urine
subject: Cyclosporins/urine
subject: Female
subject: Glutamate Dehydrogenase/blood
subject: Humans
subject: Kidney Transplantation
subject: Liver/metabolism
subject: Liver Diseases/metabolism
subject: Male
subject: gamma-Glutamyltransferase/blood

description: Ciclosporin, an immunosuppressant, is metabolized by the liver cytochrome P450 system. Changes in the pattern of its metabolites in blood and urine in patients with disturbed liver function have been studied. Forty seven kidney graft patients receiving 2.9 mg/kg/d ciclosporin b.i.d., and no additional medication that would interfere with ciclosporin metabolism, were allocated to three groups according to liver function: I with normal liver function (n = 19), II with elevated liver enzyme activity or bilirubin concentration in serum (n = 20), and III with cholestasis (n = 8). Ciclosporin and 17 metabolites were determined in blood and 24 h-urine. In blood the trough concentrations of metabolites M19 and M1A were significantly higher in group III than in groups I and II. The total quantity of metabolites excreted in 24 h-urine was significantly different for H230, M4N69 and M1A (group III greater than I = II). Renal excretion of the daily dose of ciclosporin in patients in group I was 2.7%, group II 3% and group III 5.7%. In group III compared to group I the ciclosporin metabolite pattern was shifted to a relatively higher concentration of M19 in blood and of H 230, M19 and M1A in urine. Since high ciclosporin metabolite concentrations appear to be associated with nephrotoxicity, the metabolite pattern in patients with impaired liver function should be monitored.
Different activation states of human lymphocytes after antibody-mediated stimulation via CD3 and the alpha/beta T-cell receptor
Creators: name: Schlitt, Hans-Jürgen
name: Schwinzer, R.
name: Wonigeit, K.
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: Antibodies, Monoclonal/diagnostic use
subject: Antigens, CD3
subject: Antigens, Differentiation/analysis
subject: Antigens, Differentiation, T-Lymphocyte/physiology
subject: Cyclosporins/pharmacology
subject: Cytotoxicity, Immunologic
subject: Humans
subject: Interleukin-2/biosynthesis
subject: Kinetics
subject: Lymphocyte Activation/immunology
subject: Muromonab-CD3
subject: Phenotype
subject: Receptors, Antigen, T-Cell/physiology
subject: Receptors, Antigen, T-Cell, alpha-beta
subject: Receptors, Interleukin-2/physiology

description: BMA031 is an IgG2b antibody directed towards the human alpha/beta T-cell receptor that is able to induce proliferation of peripheral blood mononuclear cells independent of antibody crosslinking. The proliferative response to BMA031 during the first 3 days of culture is usually of similar magnitude to that induced by the IgG2a CD3 antibody OKT3 but decreases quickly afterwards. Stimulation by BMA031 induces no measurable IL-2 release, very low expression of the IL-2 receptor, and does not trigger cytotoxic effector function. However, cross-linking of the antibody or addition of IL-2 leads to enhanced and prolonged proliferation, strong IL-2 receptor expression, and cytotoxic activity, features that are usually found after stimulation by the IgG2a CD3 antibody OKT3 in soluble form. The stimulatory effect of BMA031 cannot be diminished by IL-2 receptor blocking, whereas stimulation by OKT3 is strongly reduced. Moreover, proliferation induced by BMA031 has lower sensitivity to inhibition by ciclosporin than OKT3. From these results two major conclusions can be drawn: (1) an IL-2-independent way of activation may be important for the short-term proliferation of the T cells stimulated by BMA031 and (2) after stimulation by BMA031, cells reach a state of activation that is different from that induced by OKT3. These differences are most likely related to the different specificities of the antibodies, alpha/beta TcR versus CD3, suggesting that different activation signals are triggered via CD3 and via the alpha/beta TcR.
Magnetization dynamics in the presence of pure spin currents in magnetic single and double layers in spin ballistic and diffusive regimes
Creators: name: Mosendz, O.
name: Woltersdorf, Georg
name: Kardasz, B.
name: Heinrich, B.
name: Back, Christian
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 530 Physik

description: In this paper we study the spin transport by using the spin-pumping effect in epitaxial magnetic single and double layer film structures. For the magnetic single layer sample we show the spin-pumping-induced interface damping increases and saturates with the Au capping layer thickness. In addition magnetic double layerstructures allowed us to investigate both the spin-pump and spin-sink effects. Coupling of pure spin currents to the magnetization via spin-sink effect is studied using time-resolved magneto-optical Kerr effect. These measurements were used to study the propagation of pure spin currents across a Au spacer layer between the two ferromagnets. The propagation of spin momentum density through the Au spacer layer was well described by spin-diffusion equation, which takes into account electron momentum and spin-flip scattering. The spindiffusion theory was integrated into modified Landau-Lifshitz equations accounting in self-consistent manner for spin-pump/sink mechanism and spin momentum density propagation. Good agreement between theory and experimental data was found.
Transitions to three-dimensional flows in a cylinder driven by oscillations of the sidewall
Creators: name: Panades, C.
name: Marques, F.
name: Lopez, J. M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The transition from two-dimensional to three-dimensional flows in a finite circular cylinder driven by an axially oscillating sidewall is explored in detail. The complete symmetry group of this flow, including a spatio-temporal symmetry related to the oscillating sidewall, is $Z_2\times O(2)$. Previous studies in flows with the same symmetries, such as symmetric bluff-body wakes and periodically forced rectangular cavities, were unable to obtain the theoretically predicted bifurcation to modulated traveling waves. In the simpler cylindrical geometry, where the azimuthal direction is physically periodic, we have found these predicted modulated traveling waves as stable fully saturated nonlinear solutions for the first time. A careful analysis of the base states and their linear stability identifies different parameter regimes where three-dimensional states that are either synchronous with the forcing or quasiperiodic, corresponding to different symmetry-breaking processes. These results are in good agreement with theoretical predictions and previous results in similar flows. These different regimes are separated by three codimension-two bifurcation points that are yet to be fully analyzed theoretically. Finally, the saturated nonlinear states and their properties in different parameter regimes are analyzed.
description: 22 pages, 15 figures, submitted to Journal of Fluid Mechanics
Dihedral coverings of trigonal curves
Creators: name: Degtyarev, Alex
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14H30, 14H45, 14H50

description: We classify and study trigonal curves in Hirzebruch surfaces admitting dihedral Galois coverings. As a consequence, we obtain certain restrictions on the fundamental group of a plane curve~$D$ with a singular point of multiplicity $(°D-3)$.
Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals
Creators: name: Schwinzer, R.
name: Sommermeyer, H.
name: Schlitt, Hans-Jürgen
name: Schmidt, R. E.
name: Wonigeit, K.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Antibodies, Monoclonal/immunology
subject: Antigens, CD/immunology
subject: Antigens, CD2
subject: Antigens, CD3
subject: Antigens, Differentiation, T-Lymphocyte/immunology
subject: Calcium/physiology
subject: Epitopes
subject: Flow Cytometry
subject: Humans
subject: Lymphocyte Activation
subject: Receptors, Antigen, T-Cell/physiology
subject: Receptors, Immunologic/immunology
subject: Signal Transduction
subject: T-Lymphocytes/immunology
subject: Thymus Gland/cytology

description: Monoclonal antibodies (mAb) against the CD3/T cell receptor (TcR) complex were analyzed for their ability to activate human thymocytes. In addition to mAb detecting epitopes on the CD3 complex (OKT3, BMA 030) the activation potential of recently developed mAb against common epitopes on the alpha/beta T-cell receptor (anti-TcR mAb: BMA 031, BMA 032) was evaluated. Several differences were observed between the two types of mAb: (a) Binding of the tested anti-CD3 mAb to thymocytes resulted in a rapid increase in the level of cytoplasmic free calcium ions [Ca2+]i, whereas no significant changes in [Ca2+]i were detected in thymocytes stimulated with BMA 031 or BMA 032. (b) Induction of effective proliferation induced by mAb OKT3 depended on exogenous IL-2 and in addition on the presence of accessory cells or phorbol-ester. Proliferation induced by BMA 031 only required exogenous IL-2. (c) OKT3 but not BMA 031 inhibited proliferation of thymocytes induced via the CD2 molecule. These studies indicate that anti-CD3 and anti-TcR mAb transduce different signals in thymocytes. Since the two types of mAb are directed to the same molecular complex the observed differences also support the idea that there are functionally different compartments in the CD3/TcR complex which may activate different signaling pathways.
Linking Roman Coins: Current Work at the American Numismatic Society
Creators: name: Meadows
name: Gruber
name: Bransbourg
Publisher: name: Zenodo
Year: 2013
Subjects: Linked Open Data, Roman Numismatics

description: This paper details a current project at the American Numismatic Society: Online Coins of the Roman Empire (OCRE), an open-access catalogue of Roman Imperial coin types. The paper discusses linked data approaches applied to numismatic collections, the application architecture of the project, and the practical functionality of the project’s web interface, illustrating its value to researchers.
POLARIX: a pathfinder mission of X-ray polarimetry
Creators: name: Costa, Enrico
name: Bellazzini, Ronaldo
name: Tagliaferri, Gianpiero
name: Matt, Giorgio
name: Argan, Andrea
name: Attina', Primo
name: Baldini, Luca
name: Basso, Stefano
name: Brez, Alessandro
name: Citterio, Oberto
name: Di Cosimo, Sergio
name: Cotroneo, Vincenzo
name: Fabiani, Sergio
name: Feroci, Marco
name: Ferri, Antonella
name: Latronico, Luca
name: Lazzarotto, Francesco
name: Minuti, Massimo
name: Morelli, Ennio
name: Muleri, Fabio
name: Nicolini, Lucio
name: Pareschi, Giovanni
name: Di Persio, Giuseppe
name: Pinchera, Michele
name: Razzano, Massimiliano
name: Reboa, Luigia
name: Rubini, Alda
name: Salonico, Antonio Maria
name: Sgro', Carmelo
name: Soffitta, Paolo
name: Spandre, Gloria
name: Spiga, Daniele
name: Trois, Alessio
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Since the birth of X-ray astronomy, spectral, spatial and timing observation improved dramatically, procuring a wealth of information on the majority of the classes of the celestial sources. Polarimetry, instead, remained basically unprobed. X-ray polarimetry promises to provide additional information procuring two new observable quantities, the degree and the angle of polarization. POLARIX is a mission dedicated to X-ray polarimetry. It exploits the polarimetric response of a Gas Pixel Detector, combined with position sensitivity, that, at the focus of a telescope, results in a huge increase of sensitivity. Three Gas Pixel Detectors are coupled with three X-ray optics which are the heritage of JET-X mission. POLARIX will measure time resolved X-ray polarization with an angular resolution of about 20 arcsec in a field of view of 15 arcmin $\times$ 15 arcmin and with an energy resolution of 20 % at 6 keV. The Minimum Detectable Polarization is 12 % for a source having a flux of 1 mCrab and 10^5 s of observing time. The satellite will be placed in an equatorial orbit of 505 km of altitude by a Vega launcher.The telemetry down-link station will be Malindi. The pointing of POLARIX satellite will be gyroless and it will perform a double pointing during the earth occultation of one source, so maximizing the scientific return. POLARIX data are for 75 % open to the community while 25 % + SVP (Science Verification Phase, 1 month of operation) is dedicated to a core program activity open to the contribution of associated scientists. The planned duration of the mission is one year plus three months of commissioning and SVP, suitable to perform most of the basic science within the reach of this instrument.
description: 42 pages, 28 figures
On the length of chains of proper subgroups covering a topological group
Creators: name: Banakh, Taras
name: Repovš, Dušan
name: Zdomskyy, Lyubomyr
Publisher: name: arXiv
Year: 2010
Subjects: subject: Logic (math.LO)
subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: Primary: 03E17, 54H11, Secondary: 54D20

description: We prove that if an ultrafilter L is not coherent to a Q-point, then each analytic non-sigma-bounded topological group G admits an increasing chain of its proper subgroups such that: (i) U_{a in b(L)} G_a=G; and $(ii)$ For every sigma-bounded subgroup H of G there exists a such that H is a subset of G_a. In case of the group Sym(w) of all permutations of w with the topology inherited from w^w this improves upon earlier results of S. Thomas.
Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction
Creators: name: Schlitt, Hans-Jürgen
name: Christians, U.
name: Bleck, J.
name: Kohlhaw, K.
name: Ringe, B.
name: Bunzendahl, H.
name: Sewing, K. F.
name: Wonigeit, K.
name: Pichlmayr, R.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: Cyclosporin, role of metabolites, liver transplantation - Metabolites of cyclosporin, in liver transplantation
subject: 610 Medizin
subject: Cyclosporins/pharmacology
subject: Humans
subject: Immunosuppression
subject: Immunosuppressive Agents/pharmacology
subject: Liver/physiopathology
subject: Liver Transplantation
subject: Lymphocyte Culture Test, Mixed
subject: Monitoring, Physiologic
subject: Postoperative Complications

description: The aim of this study was to analyse the immunosuppressive contribution of cyclosporin metabolites in liver-grafted patients. Therefore the immunosuppressive potency of 17 metabolites, alone and in combination, was tested in human mixed lymphocyte cultures, and the results were correlated with metabolite blood levels in liver-grafted patients. Of the 17 metabolites tested only six highly lipophilic metabolites showed a detectable immunosuppressive activity of up to 10% of the activity of cyclosporin; the effect of combining metabolites was additive. For calculation of the in vivo activity, blood levels of seven major cyclosporin metabolites were determined in liver-grafted patients with normal liver function (group A, 43 episodes) and with severe hyperbilirubinaemia (group B, 66 episodes). Both patient groups had comparable levels of parent drug (122.9 +/- 17.4 vs. 111.1 +/- 23.5 ng/ml by HPLC) and similar blood levels of the highly lipophilic metabolites 17, 1 and 18. By contrast, blood levels of the less lipophilic metabolites 8, 9, 26 and 203-218 were substantially increased in group B (P less than 0.05). High overall metabolite blood levels in group B were also indicated by a non-specific monoclonal RIA (520 +/- 199 ng/ml for group A vs. 1318 +/- 407 ng/ml for group B). Despite the very high levels in group B, however, the overall contribution of the metabolites to immunosuppression was similar in both groups (12.6 +/- 5.0% for group A vs. 13.8 +/- 5.6% for group B). These findings indicate that, despite a marked accumulation of cyclosporin metabolites in patients with severe cholestatic liver dysfunction, their immunosuppressive contribution remains low.(ABSTRACT TRUNCATED AT 250 WORDS)
A study of high-energy proton induced damage in Cerium Fluoride in comparison with measurements in Lead Tungstate calorimeter crystals
Creators: name: Dissertori, G.
name: Lecomte, P.
name: Luckey, D.
name: Nessi-Tedaldi, F.
name: Otto, Th.
name: Pauss, F.
name: Roesler, S.
name: Urscheler, Ch.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A Cerium Fluoride crystal produced during early R&D studies for calorimetry at the CERN Large Hadron Collider was exposed to a 24 GeV/c proton fluence Phi_p=(2.78 +- 0.20) x 10EE13 cm-2 and, after one year of measurements tracking its recovery, to a fluence Phi_p=(2.12 +- 0.15) x 10EE14 cm-2. Results on proton-induced damage to the crystal and its spontaneous recovery after both irradiations are presented here, along with some new, complementary data on proton-damage in Lead Tungstate. A comparison with FLUKA Monte Carlo simulation results is performed and a qualitative understanding of high-energy damage mechanism is attempted.
description: Submitted to Elsevier Science on May 6th, 2010; 11 pages, 8 figures
T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: evidence for two different modes of activation
Creators: name: Schlitt, Hans-Jürgen
name: Kurrle, R.
name: Wonigeit, K.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Antibodies, Monoclonal/immunology
subject: Antigen-Presenting Cells/immunology
subject: Antigens, CD3
subject: Antigens, Differentiation, T-Lymphocyte/physiology
subject: Dose-Response Relationship, Immunologic
subject: Epitopes
subject: Humans
subject: Immunoglobulin Isotypes/immunology
subject: Immunologic Techniques
subject: Lymphocyte Activation
subject: Phorbol Esters/pharmacology
subject: Receptors, Antigen, T-Cell/physiology
subject: T-Lymphocytes/physiology

description: The mouse monoclonal antibody (mAb) BMA031 (IgG2b) has recently been described to be directed against a monomorphic part of the human T cell receptor (TcR) alpha/beta. In vitro analysis of its stimulatory potential for mononuclear cells revealed two patterns of responsiveness. Out of 35 tested individuals only 2 generated a proliferative response to low antibody concentrations (15 ng/ml; "high responders"), the others ("low responders") responded only to high antibody concentrations (1.5 micrograms/ml); the anti-CD3 mAb UCHT1 (IgG2b) stimulated only the two high responders. This response pattern to BMA031 was determined by the accessory cell compartment in the culture. Stimulation by BMA031 in low responders demonstrated some unusual features: (a) high antibody concentrations were required, (b) addition of autologous serum had no inhibitory effect and (c) vigorous depletion of macrophages reduced but did not abolish the proliferative response. These characteristics were shared by two other mAb, BMA032 and BW239/347, presumably directed against the TcR alpha/beta but not by several other antibodies to the TcR/CD3 complex. Thus, the results demonstrate unusual stimulatory properties of three anti-TcR alpha/beta mAb, inducing a proliferative response without antibody cross-linking. This suggests that the stimulatory effect of anti-TcR/CD3 complex mAb is not only determined by their isotype, but also strongly depends on their epitope specificity.
Access to oncology physical rehabilitation services in British Columbia
Creators: name: Sayyari, Sarah
Publisher: name: University of British Columbia
Year: 2018

description: Background: Cancer survivors report unique health complications associated with their treatment. Common symptoms include pain, compromised physical functioning, and lymphedema. Although these complications are highly responsive to physical therapy, many cancer survivors do not receive adequate physical therapy care. Furthermore, the delivery of physical therapy services for cancer survivors in British Columbia (BC) has not yet been investigated, warranting an inquiry specific to BC. Purpose: To develop an accurate description of the physical therapy services and programs currently accessible to oncology patients within BC’s public health care system. Methods: A standardized survey was used to investigate the provision of physical therapy to cancer survivors across BC. Public health care sites offering physical therapy services were identified through a comprehensive list of BC hospitals and out-patient health centres. Public practice health care professionals responsible for overseeing physical therapy at each site were requested to complete a survey regarding the physical therapy care provided to cancer survivors at their respective location. Results: Of the 98 sites contacted, surveys were collected for 92 for an overall response rate of 94%. Seventy-one (77%) of sites offered physical therapy to oncology patients, and two (2%) reported having an oncology-specific rehabilitation program, both of which were exclusive to breast cancer survivors and located in the lower mainland (Vancouver and Surrey). Thirty-one (44% of) participants agreed that the services currently being offered at their site were meeting the needs of their patients, 15 (21%) did not consider current services to be adequately meeting the needs of their oncology population, and 25 (35%) were unsure. The most common reasons for not meeting patient needs was lack of funding (83%), lack of professionals experienced in oncology rehabilitation (73%), and lack of resources (e.g., equipment) (70%). Conclusion: In BC, only two public health care sites deliver oncology-specific rehabilitation programs. The remaining sites offer services to oncology patients based on need. A minority of sites report meeting patient rehabilitation needs, with primary barriers being lack of funding, resources, and specialized health care professionals.
Integrated active fire retrievals and biomass burning emissions using complementary near-coincident ground, airborne and spaceborne sensor data
Creators: name: Schroeder, Wilfrid
name: Ellicott, Evan
name: Ichoku, Charles
name: Ellison, Luke
name: Dickinson, Matthew B.
name: Ottmar, Roger D.
name: Clements, Craig
name: Hall, Dianne
name: Ambrosia, Vincent
name: Kremens, Robert
Publisher: name: Elsevier
Year: 2013
Subjects: Airborne scanner
Biomass burning
Fire emissions
Fire radiative power
GOES
MODIS
Remote sensing

description: Ground, airborne and spaceborne data were collected for a 450ha prescribed fire implemented on 18 October 2011 at the Henry W. Coe State Park in California. The integration of various data elements allowed near-coincident active fire retrievals to be estimated. The Autonomous Modular Sensor-Wildfire (AMS) airborne multispectral imaging system was used as a bridge between ground and spaceborne data sets providing high-quality reference information to support satellite fire retrieval error analyses and fire emissions estimates. We found excellent agreement between peak fire radiant heat flux data (<1% error) derived from near-coincident ground radiometers and AMS. Both MODIS and GOES imager active fire products were negatively influenced by the presence of thick smoke, which was misclassified as cloud by their algorithms, leading to the omission of fire pixels beneath the smoke, and resulting in the underestimation of their retrieved fire radiative power (FRP) values for the burn plot, compared to the reference airborne data. Agreement between airborne and spaceborne FRP data improved significantly after correction for omission errors and atmospheric attenuation, resulting in as low as 5% difference between Aqua/MODIS and AMS. Use of in situ fuel and fire energy estimates in combination with a collection of AMS, MODIS, and GOES FRP retrievals provided a fuel consumption factor of 0.261kgMJ⁻¹, total energy release of 14.5e+06MJ, and total fuel consumption of 3.8e+06kg. Fire emissions were calculated using two separate techniques, resulting in as low as 15% difference for various species.
Theory of pseudospin excitations in coaxial nanotubes
Creators: name: Scharf, Benedikt
name: Fabian, Jaroslav
name: Matos-Abiague, Alex
Publisher: name: Universität Regensburg
Year: 2010
Subjects: subject: collective excitations, pseudospintronics, ferromagnetic resonance
subject: 530 Physik

description: In two-dimensional electron gases confined to two coaxial tubes the "tube degree of freedom" can be described in terms of pseudospin-1/2 dynamics. The presence of tunneling between the two tubes leads to a collective oscillation known as pseudospin resonance. We employ perturbation theory to examine the dependence of the frequency of this mode with respect to a coaxial magnetic field for the case of small intertube distances. Coulomb interaction leads to a shift of the resonance frequency and to a finite lifetime of the pseudospin excitations. The presence of the coaxial magnetic field gives rise to pronounced peaks in the shift of the resonance frequency. For large magnetic fields this shift vanishes due to the effects of Zeeman splitting. Finally, an expression for the linewidth of the resonance is derived. Numerical analysis of this expression suggests that the linewidth strongly depends on the coaxial magnetic field, which leads to several peaks of the linewidth as well as regions where damping is almost completely suppressed.
Wikipedia information flow analysis reveals the scale-free architecture of the Semantic Space
Creators: name: Masucci, A. P.
name: Kalampokis, A.
name: Eguíluz, V. M.
name: Hernández-García, E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In this paper we extract the topology of the semantic space in its encyclopedic acception, measuring the semantic flow between the different entries of the largest modern encyclopedia, Wikipedia, and thus creating a directed complex network of semantic flows. Notably at the percolation threshold the semantic space is characterised by scale-free behaviour at different levels of complexity and this relates the semantic space to a wide range of biological, social and linguistics phenomena. In particular we find that the cluster size distribution, representing the size of different semantic areas, is scale-free. Moreover the topology of the resulting semantic space is scale-free in the connectivity distribution and displays small-world properties. However its statistical properties do not allow a classical interpretation via a generative model based on a simple multiplicative process. After giving a detailed description and interpretation of the topological properties of the semantic space, we introduce a stochastic model of content-based network, based on a copy and mutation algorithm and on the Heaps' law, that is able to capture the main statistical properties of the analysed semantic space, including the Zipf's law for the word frequency distribution.
description: 12 pages, in press at PloS ONE
Non-convergence of the critical cooling timescale for fragmentation of self-gravitating discs
Creators: name: Meru, Farzana
name: Bate, Matthew R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We carry out a resolution study on the fragmentation boundary of self-gravitating discs. We perform three-dimensional Smoothed Particle Hydrodynamics simulations of discs to determine whether the critical value of the cooling timescale in units of the orbital timescale, beta_{crit}, converges with increasing resolution. Using particle numbers ranging from 31,250 to 16 million (the highest resolution simulations to date) we do not find convergence. Instead, fragmentation occurs for longer cooling timescales as the resolution is increased. These results suggest that at the very least, the critical value of the cooling timescale is longer than previously thought. However, the absence of convergence also raises the question of whether or not a critical value exists. In light of these results, we caution against using cooling timescale or gravitational stress arguments to deduce whether gravitational instability may or may not have been the formation mechanism for observed planetary systems.
description: Accepted for publication by MNRAS Letters. 6 pages, 3 figures