cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biodiversity and Nature-based Innovations for Mitigating Adverse Impacts of Climate Change
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The Global Risks Report 2022 of the World Economic Forum lists biodiversity loss as the #3 greatest threat to humanity over the next decade, exceeded only by extreme weather (#2) and climate action failure (#1). While awareness of dangers presented by climate change have increased, the associated consequences of biodiversity loss are often under-appreciated. Biodiversity—the scaffolding for what we broadly define as nature—is essential for human existence and quality of life. As the world’s largest university-managed network of natural areas, the UC Natural Reserve System (UCNRS) serves as an opportunity incubator fostering new modes of collaboration, accelerating innovation, and ultimately translating science and scholarship into policy that serves both state and national interests. Equally important, the UCNRS fosters field-based experiential learning that creates new pathways for undergraduates from under-represented backgrounds to enter the workforce as innovators and problem-solvers for people and nature. In this proposal, the UCNRS seeks to apply and scale the next generation of environmental technology and education-based solutions, including artificial intelligence (AI) and machine learning, edge computing, unmanned aerial vehicles (UAVs), low earth orbiting microsatellites, and the Internet of Things (IoT) in new ways, and with the goal of making these environment-focused tools/applications smarter, cheaper and widely accessible in the public domain. Additionally, this proposal seeks outcomes that will benefit Climate Vulnerable Communities, including building new pathways for undergraduates from under-represented backgrounds to enter the climate and environmental workforce. In summary, the projects outlined below leverage existing infrastructure and resources to accelerate nature-based climate solutions by: (1) developing the capacity to remotely assess biodiversity; (2) understanding post-fire resilience of individual plants and/or plant communities to wildfire; (3) establishing a coastal monitoring network that can identify and aid in addressing impacts of global climate change for coastal communities; (4) building an inclusive and diverse workforce of conservation and climate scientists; and (5) understanding how fuels and land use management choices affect subsequent risks from wildfires.
Tephritis matricariae
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Tephritis
Tephritis matricariae

description: Tephritis matricariae (Loew, 1844)
Trypeta matricariae Loew, 1844: 389. Syntypes. Greece (Greek Is. & Rhodus [= Rhodes]) & Turkey (Kleinasien [= Asia Minor]) (ZMHB).
Distribution. PA: Austria & Balkans S to Mediterranean, Egypt, Netherlands, Turkey.
Egyptian localities. Coastal Strip: Burg, Mariout. Eastern Desert: Wadi Zohleiga. Lower Nile Valley and Delta:
Cairo and neighborhood. Sinai.
Host plants. Flower heads of European hawkweed H. lactucella Wallr.) and mouse-ear hawkweed (Hieracium
pilosella L.). Source: Merz (1994).
Dates of collection. January to April.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 176, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Broadening Participation and Seeding Climate Innovation for the Central Coast
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: UCSB proposes to use $1 million in Climate Action Innovation & Entrepreneurship funds to lay the foundation for a regional ecosystem delivering practical, equitable, and scalable mitigations and adaptations focused on climate action for the state of California. Our vision is to build on regional resources and expertise in materials science, agriculture, and aquaculture and leverage our campus strengths in life-cycle analysis to understand the benefits and marketability of new technologies, ensure equitability in deployment and impact, and assess the practicality and scalability through testbeds and policy. We will implement a series of community-building activities and provide innovation fellowships to engage a broader suite of scholars, local industry leaders, investors, and community members in climate action I&E. Students and postdoctoral researchers supported by these funds will participate in a novel training program for climate action innovation and entrepreneurship. Our planned activities leverage existing I&E resources and infrastructure to accelerate climate action solutions for California communities, particularly those most vulnerable to climate emergencies, disasters, and inequities. In addition, we expect that our community-building activities as well as our focus on broadening faculty and researcher participation will yield long-term sustainable increases in climate action I&E that will extend well beyond the funding period.
Detecting signatures of natural selection in genetic data
Creators: name: Bhatia, Aatish
Publisher: name: No Publisher Supplied
Year: 2013

description: I report on three studies where I identify signatures of natural selection in humans, and dissect the genetic architecture of complex phenotypic traits in yeast. In chapter 2, I discuss the results of a quantitative trait mapping study, where we showed that yeast growth can be characterized by multiple biologically-relevant growth parameters obtained by fitting yeast growth OD data to a sigmoid function. We identified quantita- tive trait loci (QTL) and gene-gene interactions driving variation in these yeast growth parameters. We analyzed the environment dependence of these QTLs and gene-gene interactions, and identified a common gene, FLO8, which interacts with other genes in an environment specific fashion to affect distinct growth phenotypes. In chapter 3, I describe our published study where we applied quantitative trait locus mapping to wildtype yeast strains, and identified linked clusters of genetic variants that contributed to variation in the sporulation efficiency of these strains. In chapter 4, I describe our work on identifying signatures of natural selection in the human lineage, specifically in the Maasai people in East Africa. Our work suggests that the Maasai have under- gone recent diet induced positive natural selection that may confer protection against hyperlipidemia and cardiac diseases.
UCLA Climate Action Innovation and Entrepreneurship Award Application
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: With funding from the UC Climate Action Innovation & Entrepreneurship Awards, UCLA TDG plans to expand its I&E efforts on the following climate priorities:
 - Water & Drought Management
 - Community Health
 - Clean Energy & Energy Efficiency
 - Clean Transportation

 The record-breaking heat wave that much of California experienced in Sept, 2022 was a reminder of how increased temperatures will be especially dangerous for people in vulnerable communities. Homes in lower-income neighborhoods are less likely to have air-conditioning than those in wealthier neighborhoods. And lower-income neighborhoods tend to be more densely populated, thereby creating an urban heat island effect.

 Some of the least-expensive near-term solutions to address the heat risk that vulnerable communities face are new ways of keeping homes and businesses cooler without the use of air-conditioning. UCLA’s portfolio of research innovations includes a number of novel technologies in this area. Lab-scale testing of these innovations has shown remarkable reductions in heat transfer to buildings, compared to conventional construction. Funding from the UC Climate Action I&E Awards would facilitate scale-up and refinement of these technologies, to prepare them for implementation in real-world settings.

 Another factor that more severely affects people in vulnerable communities during heat waves is decreased air quality. Many lower income neighborhoods suffer from poor air quality because of their location adjacent to freeways and industrial sites. UCLA researchers are working on a number of technologies that will accelerate the transition to electric vehicles, reduce emissions from manufacturing plants, and improve emission-free power generation.

 With California’s drought continuing into another year, new technologies that ensure a reliable water supply are becoming more important. The recent water crises in Flint, MI, and Jackson, MS, have demonstrated how water supplies in vulnerable communities are often at risk when environmental factors change. UCLA researchers have active research programs that have produced improved water filtration, testing, and monitoring technologies. Funding from the UC Climate Action Awards would allow these researchers to move through their final development and validation steps so that the technologies could be brought into service in the near future.
Harttia absaberi Oyakawa, Fichberg & Langeani 2013
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Harttia
Harttia absaberi

description: Harttia absaberi Oyakawa, Fichberg & Langeani (2013).
Paratypes: 1 lot, 1 specimen; DZSJRP 2741, 67.6 mm SL, rio Passa Cinco, Fazenda Palmeira, Ipeúna, São Paulo, Brazil, 22°26’8.9874"S, 47°43’8.004”W, cols. Equipe Laboratório de Citogenética UFSCar.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 443, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Tephritis praecox
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Tephritis
Tephritis praecox

description: Tephritis praecox (Loew, 1844)
Trypeta praecox Loew, 1844: 391. Lectotype. Greece (Rhodes) (ZMHB). Tephritis poecilura Loew, 1869: 21. Unspecified type. Spain (ZMHB). Distribution. PA: Afghanistan, Canary Is., coastal w. & s. Europe, Israel, North Africa. Egyptian localities. Lower Nile Valley and Delta: Kerdassa.
Host plants. Flower heads of field marigold (Calendula arvensis (Vaill.) L.). Source: Merz (1994). Dates of collection. May.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 176, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
title: Husk Tomato :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: New Varieties of Plants
Husk Tomato

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Adaptive two-stage seamless sequential design for clinical trials
Creators: name: Gao, Ping
name: Li, Yingqiu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: We propose an adaptive sequential testing procedure for the selection and testing of multiple treatment options, such as dose/regimen, different drugs, sub-populations, endpoints, or a mixture of them in a seamlessly combined phase II/III trial. The selection is to be made at the end of phase 2 stage. Unlike in many of the published literature, the selection rule is not required to be to “select the best”, and does not need to be pre-specified, which provides flexibility and allows the trial investigators to use any efficacy and safety information/criteria, or surrogate or intermediate endpoint to make the selection. Sample size and power calculations are provided. The calculations have been confirmed to be accurate by simulations. Interim analysis can be performed after the selection, sample size can be modified if the observed efficacy deviates from the assumed. Inference after the trial, including p-value, median unbiased point estimate and confidence intervals, are provided. By applying a dominance theorem, the procedure can be applied to normal, binary, Poisson, negative binomial distributed endpoints and time-to-event endpoints, and a mixture of these distributions (in trials involving endpoint selection).
Spaces of immigration
Creators: name: Boland Erkkila, Catherine Clare
Publisher: name: No Publisher Supplied
Year: 2013

description: From the mid-nineteenth through early twentieth centuries, American railroad companies played a crucial role in shaping the physical and cultural landscape of the nation. These companies altered the land by constructing tracks, building stations, and platting towns. Railroad companies also redefined the cultural landscape of the nation by heavily promoting immigration, targeting specific ethnic groups that railroad officials considered desirable, such as northern Europeans, attracting them with employment opportunities, sale of cheap lands, and reduced transportation rates.  Although dependent on immigrant traffic and land sales, railroad companies largely catered to the expectations of middle-class American citizens by designing their built environment in accordance with contemporary attitudes toward immigration, not only revealing class and ethnic hierarchies but also reinforcing them.    On the East Coast, railroad companies operated at ports of entry in facilities like Baltimore’s Immigrant Station (1868-1914), New York’s Castle Garden (1855-1890) and the purpose-built Ellis Island Immigration Station (1892-1954), in order to move European immigrants as swiftly as possible through the station buildings and onto waiting trains headed for the country’s interior.  On the West Coast, however, restrictive legislation for Asian immigrants, who had largely constructed the Transcontinental Railroad, resulted in a prison-like design for the Angel Island Immigration Station (1910-1940), which featured barbed wire fencing, barred windows, and racially segregated barracks.  Further along the immigrants’ journey into the United States, segregated train cars and waiting rooms quelled fears of foreign-born illness and reinforced ethnic and economic divisions between immigrants and citizen-travelers.  Yet these immigrants were a source of profit for the railroads, and company officials organized ethnic enclaves in order to settle their Midwestern lands, targeting groups known for their agricultural skills, such as the German Mennonites.  These spaces of immigration—ports of arrival, railway stations and train cars, and railway-established towns—may be read as physical manifestations of the country’s changing immigration policies, of constructed popular ideas of otherness, and of ethnic and social hierarchies in the United States.  This dissertation situates those spaces within the larger networks of American politics, capitalism, and culture.
Combatting cancer immunosuppression with engineered Listeria monocytogenes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Immunotherapy has revolutionized the treatment of cancer. However, our current arsenal of immune-boosting drugs benefits only a fraction of patients, potentially because these strategies do not adequately combat immunosuppression in the tumor microenvironment (TME). Regulatory T cells (Tregs) are a subset of immunosuppressive Foxp3+ CD4+ T cells that infiltrate tumors and dampen anti-tumor immune responses. We have discovered that the facultative intracellular bacteria Listeria monocytogenes (Lm) may boost anti-tumor immunity by impeding immunosuppression enforced by Tregs. However, this effect is dependent upon intratumoral injection of Lm. This is highly relevant, as Lm is currently under investigation in several clinical trials where it is only being introduced intravenously and it is thought to function exclusively as an adjuvant to boost anti-tumor CD8+ T cell responses. By exploring the effect of Lm administration via intratumoral (IT) and systemic (intravenous, IV) delivery on tumor progression, we have made several significant initial discoveries. First, Lm can persist selectively in tumor tissues after IV or IT delivery, indicating a proclivity for tumors and/or tumor-mediated resistance to immune clearance. Second, the therapeutic benefit of IV Lm administration is enhanced by an additional IT Lm injection (IV+IT), demonstrating the importance of the presence of Lm in tumors for shaping the immune response. Third, Lm injection in tumors reduced Foxp3 expression and Treg frequencies in tumors in a bacterial lipoprotein/Toll-like Receptor 2 (TLR2)-dependent fashion, revealing a unique role of Lm in controlling Treg biology and potentially immunotherapy. Our proposal aims to uncover: (1) how Lm persists in tumors, (2) the immune cell types critical for mediating therapeutic efficacy with combination IV+IT Lm administration, and (3) the TLR2+ immune cells responsive to bacterial lipoproteins that drive Treg loss in the TME. Ultimately, we aim to use these discoveries to engineer Lm with an enhanced capacity to activate anti-cancer immunity and overcome immunosuppression within cancers.
Role of OGDHL in aggressive prostate cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Prostate cancer causes more than 30,000 deaths annually in the United States. When prostate cancer is localized to the prostate, the 5-year survival rate for patients diagnosed with the disease is greater than 99%. However, if the disease spreads beyond the prostate, the 5-year survival rate for patients with metastatic prostate cancer is only 30%. Therefore, understanding the biology that enables prostate cancer progression, and identifying targets to slow or stop disease progression, are critical for improving outcomes for patients with advanced disease. Upon studying models of prostate cancer progression and treatment-resistance in the laboratory, and comparing them to clinical datasets from patients with metastatic prostate cancer, we have identified a new candidate target in aggressive prostate cancer cells called Oxoglutarate Dehydrogenase-Like (OGDHL). OGDHL is found at low levels in early stage prostate cancer but its abundance increases in aggressive treatment-resistant prostate cancer. In preliminary experiments in the laboratory, when we utilize various approaches to interfere with OGDHL, we can alter the growth and aggressive properties of prostate cancer. In this proposal, we aim to better understand how OGDHL contributes to prostate cancer progression and whether it can be targeted as a therapeutic strategy to delay or prevent lethal disease. Most importantly, these experiments will provide the critical preliminary data to compete for external grant funding.
Mapluroides ogloblini Diez, Fidalgo & Roig-Alsina, 2007, new species
Creators: name: Diez, Patricia
name: Fidalgo, Patricio
name: Roig-Alsina, Arturo
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Plumariidae
Mapluroides
Mapluroides ogloblini

description: Mapluroides ogloblini new species
Holotype male: Total length 5.9 mm (paratypes, 3.0– 9.3 mm). Body with alutaceous sculpture and sparse, short pubescence. Color: Dark brown with a pattern of whitish to yellowish brown areas as follows: scape, pedicel, entire posterior surface of head, posterior part of vertex, narrow paraocular band, malar area, clypeus, basal part of mandible, lateral part of pronotum, ventral surface of prosternum, narrow longitudinal band laterally on mesoscutum, tegula, triangular median spot on scutellum occupying triangular horizontal surface and upper part of nearby slanting sides (apex of triangular spot removed from posterior margin of scutellum by ¼ of its length), all legs, wing veins (except dark nebulous veins) and pterostigma. Light brown are: flagellum, upper side of propleuron, lateral spot on mesopleuron in front of mid coxa, and lateral spot on propodeum. Wings membrane hyaline.
Color variation. Large specimens present a more contrasting pattern of pale areas, while small specimens tend to be darker. The mesoscutum may lack the pale band, the triangular spot of the scutellum may be reduced or absent, the paraocular band may be lacking, the pterostigma may be brownish, and in some specimens the scape, pedicel, clypeus and base of mandible may be pale brown.
Etymology. The species is named after Alejandro A. Ogloblin, distinguished Russian hymenopterist who worked for many years in Argentina, and who collected the first specimen of this new taxon.
Material studied. Holotype male: Argentina, province of San Juan, Ruta 141, Km 197 near Caucete, 580 m a.s.l., at light, 28-I-2006, col. P. Fidalgo (MACN). Paratypes: 32 males, same data as holotype (IFML); 32 males, same data as holotype (MACN); 4 males, same data as holotype (MLP); 2 males, same data as holotype (FSCA); 1 male, Argentina, province of La Rioja, Mascasín, 23-XI-1941, at light, col. A. Ogloblin (MLP).
description: Published as part of Diez, Patricia, Fidalgo, Patricio & Roig-Alsina, Arturo, 2007, A new genus and species of Plumariidae (Hymenoptera, Chrysidoidea) from western xeric Argentina, pp. 35-41 in Zootaxa 1467 on pages 38-40, DOI: 10.5281/zenodo.176623
If this thing had never happened
Creators: name: Harvey, Daina Cheyenne
Publisher: name: No Publisher Supplied
Year: 2013

description: It has been suggested that understanding Hurricane Katrina and the federal levee failures requires a paradigm shift within sociology. Disaster and risk, race, class and inequality, urban sociology, and the sociology of trust, to name but a few areas within the discipline have all been recast since Katrina. The people who experienced Katrina also experienced a paradigm shift of sorts. The trauma and suffering Katrina inflicted upon residents of New Orleans has resulted for many in a change in expectations about the future, a change in the ways they interact with others, a change in their cultural practices, a change in the way they think about the world. My dissertation focuses on evacuees who decided to return to the Lower Ninth Ward in the aftermath of Hurricane Katrina. In the five years since Katrina evacuees have been forced to make life altering decisions, strategize about the future, negotiate the past, and deal with confusion and uncertainty. The major question this study addresses is how do people move on from major collective events. In particular I am interested in the cultural and cognitive tools people use to form long term strategies of action after major acts of social disruption. In examining how people have moved on from Hurricane Katrina, I provide a detailed analysis of how culture both enables and constrains. I also focus on the lived experience of suffering, including what people do with suffering and what suffering does to people.
title: RELEVANSI MAKANAN KHAS DAYOK NABINATUR SUKU SIMALUNGUN DALAM PELESTARIAN BUDAYA
title: Tittle deskripsi
titleType: AlternativeTitle
Creators: name: noveny, neny
Publisher: name: Zenodo
Year: 2024

description: Suku Simalungun merupakan salah satu suku besar di Sumatera Utara yang memiliki kekayaan budaya yang beragam, termasuk dalam hal kuliner. Salah satu makanan khas Suku Simalungun yang cukup unik dan menarik adalah dayok nabinatur. Makanan ini memiliki potensi untuk diangkat sebagai media pembelajaran lintas budaya, khususnya dalam memperkenalkan keanekaragaman budaya di Indonesia.
Imaging CD40 activation to enable more effective agonists for immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Immunotherapy has been one of the largest recent advances in cancer therapy. However, current immunotherapy strategies only work in a subset of patients. Blockbuster T cell therapies, like PD-1 and CTLA-4 checkpoint inhibitors, achieve objective responses in ~25% of patients. One reason for this is poor T cell infiltration of solid tumors and T cell exhaustion in the tumor microenvironment. In contrast, macrophages are adept at penetrating solid tumors, where they can either promote tumor progression or execute anti-tumor activities like engulfing cancer cells or secreting cytotoxic cytokines. One emerging immunotherapy strategy is to ‘prime’ macrophages or other myeloid cells to more efficiently stimulate an anti-cancer immune response in T cells. The leading molecular candidate in this area is the TNF superfamily receptor CD40. CD40 is expressed on macrophages, B cells and dendritic cells. CD40 is activated by CD40 ligand on helper T cells, leading to multiple anti-cancer outputs. Despite promising pre-clinical data, CD40 agonists have stumbled in the clinic. A major reason for this is a poor understanding of the molecular details of the signaling pathway, including the essential parameters of effective agonists. Soluble agonist antibody or soluble CD40 ligand is unable to fully activate CD40 compared to cell-bound or oligomerized agonists. The primary goal of this proposal is to test the hypothesis that CD40 clustering is required for full activation of the CD40 signaling pathway. A critical gap in the field is live imaging of CD40 activation, which could convincingly demonstrate CD40 clustering upon CD40 ligand binding. Establishing this technique will also enable future studies examining intracellular signaling complex assembly. In this proposal, I will use high resolution imaging and synthetic biology to visualize CD40 activation in living cells, hypothesizing that effective agonists drive CD40 oligomerization in the plasma membrane. I will also examine how different oligomerization states of CD40 ligand activate downstream signaling molecules to determine why oligomerization is required for some CD40 responses but not all. Overall, these experiments will shed light on this new cancer immunotherapy target, and inform the design of new CD40 agonists.
Harttia longipinna Langeani, Oyakawa & Montoya-Burgos 2001
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Harttia
Harttia longipinna

description: Harttia longipinna Langeani, Oyakawa & Montoya-Burgos (2001).
Paratypes: 2 lots, 7 specimens; DZSJRP 2819, 1, 96.3 mm SL, rio Pará, bridge on road BR 262, between Nova Serrana and Pará de Minas, rio São Francisco basin, Minas Gerais, Brazil, approximately 19°53’S, 44°52’W, cols. F. Langeani & J.I. Montoya-Burgos, 14 August 1998; and DZSJRP 3666, 6, 50.0¯ 85.5 mm SL, rio Grande, Sítio Grande, São Desidério, approximately 12°35’53”S, 45°5’7”W, cols. O.T. Oyakawa, A. Akama, & V. Garutti, 8 July 1998.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 443, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Spatial transcriptomics patterns and correlations with outcomes in head and neck cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Head and neck cancers are the 7th most common cancer worldwide, with over 800,000 annual cases and 400,000 annual deaths. Despite constant efforts for improving standard of care, survival rates remain poor and our ability to predict disease prognosis and behavior are limited. Investigation into spatial expression patterns in head and neck cancers may allow a better understanding of tumor heterogeneity, interactions with the immune microenvironment, and predictions in disease behavior.

 We have investigated head and neck cancer tissues for prognostic biomarkers. These include markers associated with the tumor and immune microenvironment, as well as intrinsic tumor alterations and markers. Using this data, we have been able to develop initial stratifiers of patient outcomes and identify prognostic biomarkers. However, there remains a significant need to more accurately investigate prognostic biomarkers, and understanding the role of the tumor-immune microenvironment in head and neck cancer behavior.

 Building on our prior work and revisiting biomarker analyses with novel technologies, with improved single cell and spatial analyses, can have immense benefit in identifying unique biomarker expression patterns, investigating potential treatment targets, and developing prognostic models. Spatial transcriptomics of tumors and their surrounding microenvironment are increasingly being investigated in a wide array of cancers.

 Here, we propose to utilize new spatial transcriptomic technology to correlate findings with head and neck cancer behavior. We will utilize the Nanostring GeoMx Digital Spatial Profiler in collaboration with the UC Davis Genomics Shared Resource to analyze formalin-fixed paraffin embedded head and neck cancer specimens collected from surgical cases. We will correlate tumor stage, metastatic status, tumor pathologic features, patient demographics and survival with spatial transcriptomic signatures of the primary tumor, surrounding microenvironment, and metastatic lymph nodes. We aim to identify prognostic signatures related to primary tumor and tumor-immune microenvironment expression patterns, with implications to stratify and personalize patient care. We believe this will generate valuable and novel data for publications and subsequent grant submissions.
Tephritis spreta
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Tephritis
Tephritis spreta

description: Tephritis spreta (Loew, 1861)
Trypeta spreta Loew, 1861: 297. Syntypes. Egypt (NHMW?). Type apparently lost (V. Korneyev, personal communication). Distribution. PA: Egypt.
Egyptian localities. Coastal Strip: El-Burg, Mariout. Eastern Desert: Abu Sultan, Ogret El-Sheikh, Wadi Abu Nossour, Wadi Digla, Wadi Um Elek, Wadi Zohleiga. Fayoum:?. Lower Nile Valley and Delta: Abu Rawash, Faraskour, Mazghouna.
Host plants. Unknown.
Dates of collection. March to October.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 176, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Future in the present
Creators: name: Islas-López, María
Publisher: name: No Publisher Supplied
Year: 2013

description: Future consideration in the form of plans, hopes, projects and dreams is a constitutive feature of the life of Mexican migrants and their families. This study seeks to understand this engagement with the future of transnational actors—of those that move around and those who stay. The study explores the ways in which this future consideration plays out in people’s everyday transnational living and, accordingly, how people’s future-oriented thinking is factored in transnational dynamics. Drawing on ethnographic fieldwork with families from a mountain-town in Oaxaca, Mexico with recent migrant ties to central New Jersey, this study explores the interplay of future-related processes of thought with people’s practices and the contexts of their transnational movement. My analytical focus is on three interrelated elements: a) the socio-cultural processes that the imagining of the future results from, b) the form and process of consideration of future scenarios and, c) the forms of behaviors and experiences this future consideration creates. The analysis first addresses the ways in which the processes of future consideration in this town are responsive to transnational migratory dynamics. Second, drawing from research in the cognitive sciences, I elaborate on the subjective mental processes through which social actors create images of the future. I argue that future-scenario building is an outcome of reflexive processes that occur in conversation with context and biographical history, and in relation to people’s interactions with others. Third, I show the ways in which the puzzles of transnational everyday living pose challenges for social actors’ future scenario building, exploring the ways that transnational actors conceptualize the future are consequential for strategic action. By examining these issues, this study proposes innovations to current migration scholarship, making subjective processes a central analytical focus in migration research. My findings suggest that the cognitive and emotional engagements with the future of transnational actors and the ways in which the modalities of this engagement take place produce subjectivity and action in their present. At the level of general social theory, this study addresses the projective capacity of human action and its relation to social and relational context.
VGLL3 Amplification in Sarcoma Development and Growth
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Soft tissue sarcomas are a rare and heterogeneous group of more than fifty connective tissue cancers. Patients are often treated aggressively, with surgery, radiation, and chemotherapy. Despite this multimodality approach, approximately 35% of people will develop incurable metastatic disease. Therefore, new treatments are needed for this devastating cancer. To create new therapies, targets must be identified and in the field of sarcoma, this has been met with limited success due to the disease heterogeneity and limited models to study the biology of specific sarcoma subtypes. Our lab has generated a robust and versatile system to study human sarcoma development and growth. In this model, P53 and RB1, tumor suppressors that are commonly mutated or deleted in sarcomas were targeted by CRISPR-Cas9 to generate RB1-/-P53+/- mesenchymal stem cells. To these cells, we added a library of genes to identify drivers of sarcoma formation. We have identified four drivers (YAP1, KRAS, CDK4, and PIK3CA) that each result in the development of a distinct sarcoma subtype. Interestingly, in our initial screen that identified these drivers, the transcription cofactor VGLL3 (Vestigial Like Family Member 3) was repeatedly identified as a potential driver yet, the addition of VGLL3 alone to RB1-/-P53+/- cells did not lead to the formation of sarcomas. VGLL3 was included in our primary screen because it was shown in the Cancer Genome Atlas (TCGA) data to be amplified across soft tissue sarcomas yet, the significance of this is not known. While VGLL3 is not an independent driver of sarcoma development, we hypothesize that it works in combination with other drivers to facilitate the formation and growth of sarcomas. In this study, we intend to investigate the role of VGLL3 in both the development and subsequent growth of sarcomas.
Hisonotus bocaiuva Roxo, Silva, Oliveira & Zawadzki 2013
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hisonotus
Hisonotus bocaiuva

description: Hisonotus bocaiuva Roxo, Silva, Oliveira & Zawadzki (2013).
Paratypes: 1 lot, 3 specimens; DZSJRP 16461, 22.0¯ 25.6 mm SL, córrego cachoeira, rio Jequitaí drainage, rio São Francisco basin, Bocaiúva, Minas Gerais, Brazil, 7°08’55”S, 43°49’32”W, cols. C. Oliveira, G.J.C. Silva, F.F. Roxo & T.N.A. Pereira, 14 May 2010.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 444, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
LEAPing forward with the new guidelines
Creators: name: Burks, A. Wesley
name: Wood, Robert A.
Publisher: name: Elsevier
Year: 2017

description:
In this month’s issue of the Journal, the much anticipated product of the National Institute of Allergy and Infectious Diseases–sponsored expert panel on the ‘‘Guidelines for the prevention of peanut allergy’’have been published. We strongly commend the expert panel on this thoughtful, clear, evidence-based document, which is obviously the result of a significant amount of time and discussion. There is no doubt that these recommendations will prevent the development of lifelong peanut allergy in countless numbers of children. However, although this represents a major advance in our field, there is still much to learn in the realm of food allergy prevention related not just to peanut but to other foods as well.
Heparan Sulfate Biomarker for Pancreatic Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer. This is in part due to difficulties in diagnosing the patients early where intervention would still be effective. Thus, PDAC specific markers that arise early in the disease are in high demand, to develop functional screening methods for early diagnosis. One of the key components to the cancer associated extracellular matrix is a type of carbohydrate, or glycan, called heparan sulfate (HS). HS biology is complex, but it is clear that these molecules accumulate and are structurally altered in many types of cancer. We have found that a unique type of HS, that is found in clinical heparin but rare in healthy tissue, accumulates in early stages of progression to PDAC. This type of HS is called HSAT. Notably, we show that the enzyme that produces HSAT, is elevated in early stages of the disease and correlates with poor disease prognosis. We show preliminary data that HSAT can be detected in PDAC precursor lesions and cancer tissue specimens and that it can be found circulating in the plasma from PDAC patients. We also show preliminary data that HSAT can be used as a target for cancer tracing studies. This project aims to fully investigate the potential of HSAT as a tool for the early diagnosis of PDAC, and potentially pave the way for the investigation of HSAT as a target for directed therapy against PDAC. The discovery of novel markers specific to PDAC has the potential to provide diagnostic and therapeutic strategies to combat this devastating disease, to the benefit of patients worldwide.
12-Lipoxygenase Inhibitors as a Pancreatic Ductal Adenocarcinoma Therapeutic
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Goal:
 The purpose of this study is to improve the in vitro potency of our human 12-lipoxygenase (12-LOX) inhibitors, confirm their cellular potency and optimize their basic ADME properties, with the ultimate goal of developing an effective therapeutic against pancreatic ductal adenocarcinoma (PDAC).

 Background:
 PDAC is the fourth-leading cause of cancer-related death in the United States, with a 5-year survival rate of 9%, due to the ineffective surgical and pharmaceutical treatments. Human 12‐Lipoxygenase (12‐LOX) is proposed to increase PDAC proliferation through its enzymatic product, 12-HETE, which stimulates PDAC growth. This hypothesis is supported by the published observation that higher plasma levels of 12-HETE, the 12-LOX enzymatic product, correlated with a higher incidence of recurrence and metastasis in PDAC patients. In support of this hypothesis, we determined that inhibition of 12-LOX lowered the proliferation of human PDAC cells in cell culture, thus signifying 12-LOX inhibitors as potential therapeutics.

 In 2014, we developed a potent/selective inhibitor, ML355 (IC50 = 350 nM), but recently, we utilized mutagenesis of 12-LOX and computer modeling to improve its potency 7-fold with a next generation inhibitor, named Slug001 (IC50 = 50 nM). More importantly, Slug001 was shown to be potent against PDAC cellular proliferation in our cellular assay. Based on these encouraging data, we now propose to derivatize Slug001 to optimize its potency/ drug-like properties and then characterize their cellular activity against pancreatic cancer.

 Proposal:
 We first propose to derivatize Slug001 with a suite of modifications. Slug001 was discovered with computer modeling, so our derivatives will be guided in a similar manner. Our goal is to improve its potency by filling the active site cavity more efficiently, while maintaining its cellular activity. Once potent inhibitors are developed, we will determine their potency in our human pancreatic cancer cell model. Our lead inhibitor will then be subjected to initial ADME investigations to determine its initial drug-like properties. Our ultimate goal is to perform more extensive ADMET studies and generate an IND application to initiate human clinical studies of 12-LOX inhibitors to treat PDAC.
Controlling Membrane Rupture and Vibrational Imaging of Repair Dynamics in Cancer Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The plasma membrane (PM) protects the constituents of mammalian cells from the external environment, and its integrity is essential for cell viability and proper function. Since PM rupture is regularly caused in a variety of cellular processes, cells have developed several evolutionarily conserved membrane repair mechanisms. It is now evident that an inadequate PM repair response plays a role in a variety of diseases and conditions such as heart failure, muscular dystrophies, and neurodegeneration. On the other hand an over-activated PM repair response can promote survival of cancer cells as they undergo repeated PM rupture during cancer cell growth and invasion. Therefore, the modulation of PM repair machinery has emerged as a new exciting target for therapeutic purposes. However, the identification of promising therapeutic targets depends on the direct visualization, characterization and mechanistic understanding of PM repair machinery in health and disease, with single cell resolution. This remains challenging due to the spontaneity and rapidness of the PM rupture and repair process. Herein, we aim to utilize advanced nanotechnology techniques to develop and characterize a platform for higher throughput, spatial and temporal control and visualization of membrane rupture and repair for studying mechanisms of repair in various adherent cancer cell types. Our proposed work is innovative from both technical and scientific aspects. From the technical aspect, we introduce a novel platform with the capability to controllably introduce and visualize hundreds of independent PM rupture and repair events in single cells. From a scientific perspective, such a platform will enable high throughput testing, and hence accelerate the identification of various PM-repair related machinery and therapeutic targets. Despite the novelty of the proposed work, I have confidence that this project can be successfully executed our labs. We have already proven the feasibility of fabricating nanoscale platforms with the desired characteristics, for applications other than the one proposed here.
“You can't go to war without song"
Creators: name: Jolaosho, Omotayo Tolulope
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation examines the role of performance in the constitution of activist community from the vantage point of the Anti-Privatisation Forum (APF), one of many social movements that emerged in the wake of South Africa’s democratic transition. The study begins with the premise that performance is integral to activism, constituting the very groundwork through which queries of justice occur. It updates historical scholarship on the complicated roles of anti-apartheid performances in South Africa, providing insight into shifting responses to challenges arising in the wake of democratic transition and the adoption of neoliberal economic policies. APF members actively adapted anti-apartheid songs and created new expressive forms to inform and comment on their struggles for access to water, electricity, housing, education and health facilities, the costs of which have been prohibitive due to their privatization.  Based on 16 months of fieldwork involving participant-observation, interviews, and archival research, I investigated adaptations of anti-apartheid performances to changing social dynamics including changes in activists’ relationship with the state, articulation of gender issues, emerging class-consciousness, and intergenerational linkages. The project considers performance in its multiple dimensions, ranging from routine enactments that secure, sustain, or weaken political outcomes to more practiced creative expression. I show how routine negotiations and artistic displays shaped APF’s collective identity. Furthermore, through an integrative bodily approach to the study of political performances, I consider sensory experiences and their mediation, revealing how these experiences influenced the mobilization activities that activists pursued. Particularly in moments of creative expression, sensory experiences generated positive associations that made collective political struggle desirable. In contrast, however, sensory experience also yielded aversions: combativeness generated stress, eroded solidarity, and alienated many APF members. With consideration of these varied effects, the dissertation provides an expansive analysis of mobilization, emphasizing the role of performance in the conduct of politics.