cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hersiliola Thorell 1870
Creators: name: Marusik, Yuri
name: Fet, Victor
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Hersiliidae
Hersiliola

description: Hersiliola sp. Fig. 7.2 H. simoni: Benoit 1974: 997, f. 3, 6 (♀) (?) Material examined. A slide of the epigyne (SMF, from the H. Wiehle collection) labeled as “ H. macullulata from Palestine. Comments. Unlike other species from the Middle East (Israel), this specimen has only one coil of the insemination duct, and it can be expected that its male should have a correspondingly shorter embolus. It could belong to H. lucasi (O.P.- Cambridge, 1876), which was described from Egypt and is currently synonymous with H. simoni. Conformation of the epigyne is similar to those illustrated by Benoit (1974) from Tunisia and identified as H. simoni. Benoit (1974) compared his specimen with those from Egypt.
description: Published as part of Marusik, Yuri & Fet, Victor, 2009, A survey of East Palaearctic Hersiliola Thorell, 1870 (Araneae, Hersiliidae), with a description of three new genera, pp. 75-114 in ZooKeys 16 (16) on page 84, DOI: 10.3897/zookeys.16.229, http://zenodo.org/record/576478
description: {"references": ["Benoit PLG (1974) Araignees interessantes du Museum d'Histoire Naturelle de Geneve. Revue suisse de Zoologie 81: 993 - 998.", "Cambridge OP- (1876) Catalogue of a collection of spiders made in Egypt, with descriptions of new species and characters of a new genus. Proceedings of the Zoological Society London 1876: 541 - 630."]}
Plaquette Order in a Dimerized Frustrated Spin-Ladder
Creators: name: Shlagman, Ofer
name: Shimshoni, Efrat
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the effect of spin-Peierls instability on the phase-diagram of a frustrated antiferromagnetic spin-1/2 ladder, with weak transverse and diagonal rung coupling. Our analysis focuses on a one-dimensional version of the model (i.e. a single two-leg ladder) where we consider two forms of spin-Peierls (SP) instabilities on the legs: columnar dimers (CD) and staggered dimers (SD). We particularly examine the regime of parameters (corresponding to an intermediate XXZ anisotropy) where the SP and rung coupling terms are equally relevant. In both the CD and SD cases we find that the effective field theory describing the system is a self-dual sine-Gordon model, which favors ordering and the opening of a gap to excitations. The order parameter, which reflects the interplay between the SP and rung interactions, represents a crystal of 4-spin plaquettes on which longitudinal and transverse dimers are in a superposition. Depending on the SP instability mode these plaquettes are closed or open, however both types spontaneously break reflection symmetry across the ladder. The closed plaquettes are stable, while the open plaquette-order is relatively fragile and the corresponding gap may be tuned to zero under extreme conditions. We further find that a first order transition occurs from the Plaquette order to a valence bond crystal (VBC) of dimers on the legs. It is suggestive that in a higher dimensional version of this system, this variety of distinct VBC states with comparable energies leads to the formation of domains. Effectively one-dimensional gapless spinon modes on domain boundaries can possibly account for the experimental observation of a spin-liquid behavior in a physical realization of the model.
description: 11 pages, 4 figures
Old age and frailty in deceased organ transplantation and allocation : a plea for geriatric assessment and prehabilitation
Creators: name: Weimann, Arved
name: Ahlert, Marlies
name: Seehofer, Daniel
name: Zieschang, Tania
name: Schweda, Mark
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Due to demographic ageing and medical progress, the number and proportion of older organ donors and recipients is increasing. At the same time, the medical and ethical significance of ageing and old age for organ transplantation needs clarification. Advanced age is associated with the frailty syndrome that has a negative impact on the success of organ transplantation. However, there is emerging evidence that frailty can be modified by suitable prehabilitation measures. Against this backdrop, we argue that decision making about access to the transplant waiting list and the allocation of donor organs should integrate geriatric expertise in order to assess and manage frailty and impairments in functional capacity. Prehabilitation should be implemented as a new strategy for pre-operative conditioning of older risk patients’ functional capacity. From an ethical point of view, advanced chronological age per se should not preclude the indication for organ transplantation and the allocation of donor organs.
title: Formal C2-homologation of isothiocyanates to iminothietanes
Creators: name: Heß, Andreas-Lorenz
Year: 2022

description: Gegenstand dieser Arbeit der Einbau einer CH2-CH2-Gruppe in ein Isothiocyanatstartmolekül mit dem Ziel der Ausbildung eines viergliedrigen Ringsystems. Dabei werden Lithiumcarbenoide als CH2-Donoren verwendet. Bei dem stufenweisen Einbau zweier einzelner Methylen-Einheiten, zugeführt durch die Carbenoide, entsteht ein stabiles schwefelhaltiges Ringsystem, ein Iminothietan. Diese seltene Stoffklasse besitzt eine außerordentliche chemische Stabilität. Des Weiteren weist die Reaktion eine hohe Chemoselektivität auf und toleriert eine Vielzahl reaktiver funktioneller Gruppen am Isothiocyanatstartmaterial. Eine weitere Besonderheit ist die direkte Anwendbarkeit der Methode auf ein Kohlenstoffelektrophil - in diesem Fall ein Isothiocyanat - ohne die Notwendigkeit der Installation eines Heteroatoms als Startpunkt der Verlängerung, wie es z.B. mit Bor im Rahmen der Matteson-Verlängerung klassischerweise der Fall ist. Die hier behandelte Stoffklasse ist in der verfügbaren Literatur bislang nur wenig beschrieben und könnte eine wichtige Rolle bei der Entwicklung neuer Methoden für die Produktion von Synthesebausteinen sowie als Startmaterial im Bereich der medizinischen Chemie spielen.
description: This work focuses on the insertion of a CH2-CH2 group into an isothiocyanate with the aim of forming a four-membered ring system. Thereby, lithium carbenoids function as CH2 donors. With the consecutive insertion of two single methylene units a stable sulfur-containing ring system is formed, an iminothietane cluster. This rare class of compounds is exceptionally stable. Furthermore, the reaction shows a high degree of chemoselectivity as demonstrated by the tolerance to a variety of reactive moieties attached to the starting materials used. Another special feature is the direct applicability of the method to a carbon scaffold - in this case a isothiocyanate - without the need of heteroatomic linchpins as seen, for example, in the boron-depending Matteson-Homologation. The class of substances analysed in this work has so far received only little attention in the available literature but could play a significant role in the development of new ways to access building blocks for chemical synthesis as well as starting materials in the field of medicinal chemistry.
A simplified 2HDM with a scalar dark matter and the galactic center gamma-ray excess
Creators: name: Wang, Lei
name: Han, Xiao-Fang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Due to the strong constrain from the LUX experiment, the scalar portal dark matter can not generally explain a gamma-ray excess in the galactic center by the annihilation of dark matter into $b\bar{b}$. With the motivation of eliminating the tension, we add a scalar dark matter to the aligned two-Higgs-doublet model, and focus on a simplified scenario, which has two main characteristics: (i) The heavy CP-even Higgs is the discovered 125 GeV Higgs boson, which has the same couplings to the gauge bosons and fermions as the SM Higgs. (ii) Only the light CP-even Higgs mediates the dark matter interactions with SM particles, which has no couplings to $WW$ and $ZZ$, but the independent couplings to the up-type quarks, down-type quarks and charged leptons. We find that the tension between $_{SS\to b\bar{b}}$ and the constraint from LUX induced by the scalar portal dark matter can go away for the isospin-violating dark matter-nucleon coupling with $-1.0< f^n/f^p<0.7$, and the constraints from the Higgs search experiments and the relic density of Planck are also satisfied.
description: 12 pages, 3 figures, 1 table; reference added
Danish Observing Summerschools
Creators: name: Fynbo, Johan
name: Grundahl, Frank
Publisher: name: Zenodo
Year: 2022

description: Since 2007 we have held summer schools first with students first from Copenhagen University and later with students from almost all Danish Universities. The purpose is twofold. Primarily, the objective is to give the students hands-on experience with astrophysical observations in all aspects, i.e., proposal-writing, planning, execution, analysis and presentation. The projects have included exoplanet observations (transients, radial velocities), transients (novae, supernovae, grab afterglows), lensed objects, new quasars and galaxy rotation curves. Using the NOT to train the next generation of Nordic observational astronomers is something we should keep and possibly further develop. An interesting suggestion would be to arrange a conference for Nordic students where they can present results from dedicated student observations.
Characteristics of abdominal vein thrombosis in children and adults
Creators: name: Kulkarni, Roshni
name: Philipp, Claire S.
name: Manco-Johnson, Marilyn
name: Landi, Daniel
name: Ortel, Thomas L.
name: Grant, Althea M.
name: Moll, Stephan
name: Key, Nigel S.
name: Bockenstedt, Paula
name: Heit, John A.
name: Beckman, Michele G.
name: Andersen, Judith C.
name: Shah, Nirmish R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospec-tively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal V T, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/ PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.
Phase II Prospective Open-Label Trial of Recombinant Interleukin-11 in DDAVP-Unresponsive Von Willebrand Disease and Mild or Moderate Hemophilia A
Creators: name: Kloos, Mark
name: Ragni, Margaret
name: Nichols, Timothy
name: Merricks, Elizabeth
name: Murshed, Anila
name: Novelli, Enrico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Desmopressin (DDAVP) is the treatment of choice in those with mild von Willebrand disease (VWD), yet 20% are unresponsive to DDAVP, and among the 80% who respond, the response is transient, as endothelial stores are depleted after 3 days. We, therefore, conducted a single-center Phase II clinical trial to determine safety and biologic efficacy of recombinant interleukin-11 (rhIL-11, Neumega®) in patients with VWD unresponsive or allergic to DDAVP, or mild or moderate hemophilia A (HA). Increases in VWF:RCo were observed by 48 hours after rhIL-11, with a 1.54-fold increase by day 4, 1.30-fold in VWD and 1.73-fold in HA. Similarly, by 48 hours, increases in VIII:C were observed, with a 1.65-fold increase by day 4, 1.86-fold in VWD and 1.48-fold in HA. Platelet VWFmRNA expression by qPCR increased 0.81-fold but did not correlate with plasma VWF:Ag responses. rhIL-11 was well tolerated, with grade 1 or less fluid retention, flushing, conjunctival erythema, except for transient grade 3 hyponatremia in one subject after excess fluid intake for diabetic hyperglycemia, which resolved with fluid restriction. In summary, rhIL-11 increases VWF levels in 2 of 4 DDAVP-unresponsive or allergic VWD and F.VIII levels in 4 of 5 mild or moderate hemophilia A subjects, suggesting its potential use in treatment of these disorders.
title: Quantum Computing and its Applications in Healthcare
Creators: name: Giang, Vu
Publisher: name: Old Dominion University Libraries
Year: 2023

description: This paper serves as a review of the state of quantum computing and its application in healthcare. The various avenues for how quantum computing can be applied to healthcare is discussed here along with the conversation about the limitations of the technology. With more and more efforts put into the development of these computers, its future is promising with the endeavors of furthering healthcare and various other industries.
SIDERWIN Webinar2023 Questions-by-participants
Creators: name: Serna-Ruiz, Monica
name: Weber-Zollinger, Valentine
name: Aitziber Adrados
name: Kahmann, Roland
name: Allemand, Jean-Paul
name: Panias, Dimitrios
name: Kounina, Anna
name: Lopes, Daniela V.
name: Barberousse, Morgan
name: Conte, Thierry
name: Touhami, Salah
name: Baldini, Andrea
name: Kavaleuski, Andrei
Publisher: name: Zenodo
Year: 2023

description: Questions asked by the participants during the SIDERWIN concluding webinar on the 23rd of March 2023.
An exception proves the rule: Lena Artz (1891–1976) and her legacy of botanical specimens.
Creators: name: Weeks, Andrea
Publisher: name: Zenodo
Year: 2023
Subjects: herbaria, Bionomia, hidden figures, SISRIS

description: Presentation at the Botany 2023 Special Lecture session of the Society of Herbarium Curators, Supporting inclusive and sustainable research infrastructure for systematics (SISRIS) held on 26 July 2023 in Boise, Idaho. Work to produce this talk and accompanying materials were funded by NSF grants #2022918 and #2247631. Abstract: Lena Artz is one of many thousands of individuals who documented the plant biodiversity of the southeastern United States in the mid-20th century. But her accomplishments as a pioneering explorer of the Massanutten Mountains, which were uncovered only because of ongoing herbarium digitization in Virginia, is a case study of how interrogating the legacies of poorly known collectors can advance botanical research in the present day. In 2019, the collection notebooks and professional papers of Lena Artz were discovered during the salvage of the Lord Fairfax Community College Herbarium. Despite being occasionally acknowledged in print as an early contributor to knowledge about Central Appalachian shale barren ecosystems, biographical information about Lena Artz or her professional accomplishments were largely undocumented at the time of the discovery. This presentation describes how archival research, gumshoe detective work, and the curation of Artz’s ca. 2000 sheet exsiccatae across multiple institutions have worked synergistically to uncover the life and life’s work of this hidden figure in botany. The results provide insight on why she, like many other collectors whose collections inhabit museums and databases, become forgotten. The results also reveal the time-value of her collections for contemporary studies of rare, threatened and endangered plant species, for capturing the biodiversity of landscapes long since destroyed, and for informing studies of global climate change. Lastly, I show how Bionomia can be used as a tool to improve digital data about specimens across institutions using the curation of Artz’s exsiccatae as an example. I argue that assigning universal unique ID’s to historical collectors and appending these to their digitized specimen records is a tractable challenge for the herbarium community to meet that not only will help us achieve the vision of the extended specimen concept but will make collections-based research more inclusive in the 21st century.
description: This work was funded and therefore made possible by the US National Science Foundation under grants #2022918 and #2247631.
Alterations in the hepatocyte epigenetic landscape in steatosis
Creators: name: Maji, Ranjan Kumar
name: Keßler, Sonja
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 615

description: Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Flow networks: A characterization of geophysical fluid transport
Creators: name: Ser-Giacomi, Enrico
name: Rossi, Vincent
name: Lopez, Cristobal
name: Hernandez-Garcia, Emilio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We represent transport between different regions of a fluid domain by flow networks, constructed from the discrete representation of the Perron-Frobenius or transfer operator associated to the fluid advection dynamics. The procedure is useful to analyze fluid dynamics in geophysical contexts, as illustrated by the construction of a flow network associated to the surface circulation in the Mediterranean sea. We use network-theory tools to analyze the flow network and gain insights into transport processes. In particular we quantitatively relate dispersion and mixing characteristics, classically quantified by Lyapunov exponents, to the degree of the network nodes. A family of network entropies is defined from the network adjacency matrix, and related to the statistics of stretching in the fluid, in particular to the Lyapunov exponent field. Finally we use a network community detection algorithm, Infomap, to partition the Mediterranean network into coherent regions, i.e. areas internally well mixed, but with little fluid interchange between them.
description: 16 pages, 15 figures. v2: published version
Hersiliola foordi Marusik & Fet 2009, sp. n.
Creators: name: Marusik, Yuri
name: Fet, Victor
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Hersiliidae
Hersiliola
Hersiliola foordi

description: Hersiliola foordi sp. n. urn:lsid:zoobank.org:act: 4915C8CC-EEF2-451F-A481-5BA06F4EF454 Figs 7.13-14, 8.5 Type material (3 specimens): Holotype 1♀, IRAN [01] Fars Province, 50 km NNE of Shiraz, Bamoo Reserve, 52°45’E 29°45’N, 18- 28.05.2000, Yu.M. Marusik coll. (ZMMU). Paratypes: 1♀, 1 juv.♀, IRAN [09] Fars Province, Shiraz, 52.533°E 29.607°N, 18- 26.05.2000, Yu.M. Marusik coll. (ZMMU). Etymology. The species name is a patronym honouring our colleague Stefan H. Foord (Thohoyandou, South Africa), for his contributions to in-depth modern studies of Hersiliidae. Description. Male unknown. Female: Total length 5.01-5.75. Carapace 2.1-2.25 long, 2.2-2.45 wide, femur 3.1-3.75 long, femur I/carapace length ratio 1.47-1.67. Coxae IV separated only slightly. Abdominal pattern such as in holotype of H. afghanica formed by short flat hairs of orange-light brown, dark brown, and white colour. Epigyne as in Figs 13 -14, 8.5, with septum as wide as lateral arms of median plate; median plate not well separated from epigynal plate; translucent spermathecae oval, separated by their length (height) from the epigynal opening; insemination duct short, with only one loop; fertilization duct with a long appendix-like accessory gland extending along the duct. Diagnosis. Hersiliola foordi sp. n. can be easily distinguished from all other congeners by its very short and wide insemination ducts, unseparated median plate, and lack of windows. Comments. This species, like H. lindbergi sp. n., could belong to a separate genus. Its median plate is not separated from the rest of the epigynal plate. It also has no accessory sclerites and no windows. Distribution. The species is known only from two nearby localities near Shiraz, southern Iran.
description: Published as part of Marusik, Yuri & Fet, Victor, 2009, A survey of East Palaearctic Hersiliola Thorell, 1870 (Araneae, Hersiliidae), with a description of three new genera, pp. 75-114 in ZooKeys 16 (16) on page 86, DOI: 10.3897/zookeys.16.229, http://zenodo.org/record/576478
Application of ligand- and structure-based prediction models for the design of alkylhydrazide-based HDAC3 inhibitors as novel anti-cancer compounds
Creators: name: Bülbül, Emre F.
name: Robaa, Dina
name: Sun, Ping
name: Mahmoudi, Fereshteh
name: Melesina, Jelena
name: Zessin, Matthes
name: Schutkowski, Mike
name: Sippl, Wolfgang
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in particular hydroxamic-acid-based inhibitors lack good pharmacokinetic profiles. Therefore, the development of isoform-selective non-hydroxamic acid HDAC inhibitors is a highly regarded field in medicinal chemistry. In this study, we analyzed different ligand-based and structure-based drug design techniques to predict the binding mode and inhibitory activity of recently developed alkylhydrazide HDAC inhibitors. Alkylhydrazides have recently attracted more attention as they have shown promising effects in various cancer cell lines. In this work, pharmacophore models and atom-based quantitative structure–activity relationship (QSAR) models were generated and evaluated. The binding mode of the studied compounds was determined using molecular docking as well as molecular dynamics simulations and compared with known crystal structures. Calculated free energies of binding were also considered to generate QSAR models. The created models show a good explanation of in vitro data and were used to develop novel HDAC3 inhibitors.
VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians
Creators: name: Perry, Kimberly
name: Johnson, Julie A.
name: Langaee, Taimour
name: Cavallari, Larisa H.
name: McLeod, Howard L.
name: Misher, Anne
name: Perera, Minoli A.
name: Shahin, Mohamed Hossam A.
name: Khalifa, Sherief I.
name: Patel, Shitalben
name: Meltzer, David O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The VKORC1 Asp36Tyr single nucleotide polymorphism (SNP) is one of the most promising predictors of high warfarin dose, but data on its population prevalence is incomplete. We determined the frequency of this SNP in participants from seven countries on four continents and investigated its effect on warfarin dose requirement. One thousand samples were analysed to define the population prevalence of this SNP. Those samples included individuals from Egypt, Ghana, Sudan, Kenya, Saudi Arabia, Peru and African Americans from the United States. A total of 206 Egyptian samples were then used to investigate the effect of this SNP on warfarin dose requirements. This SNP was most frequent among Kenyans and Sudanese, with a minor allele frequency (MAF) of 6% followed by Saudi Arabians and Egyptians with a MAF of 3% and 2.5%, respectively. It was not detected in West Africans, based on our data from Ghana, and a large cohort of African Americans. Egyptian carriers of the VKORC1 Tyr36 showed higher warfarin dose requirement (57.1 ± 29.4 mg/week) than those with the Asp36Asp genotype (35.8 ± 16.6 mg/week; p=0.03). In linear regression analysis, this SNP had the greatest effect size among the genetic factors (16.6 mg/week increase in dose per allele), and improved the warfarin dose variability explained in Egyptians (model R2 from 31% to 36.5%). The warfarin resistant VKORC1 Asp36Tyr appears to be confined to north-eastern Africa and nearby Middle-Eastern populations, but in those populations where it is present, it has a significant influence on warfarin dose requirement and the percent of warfarin dose variability that can be explained.
Reproduction of a conventional anthropomorphic female chest phantom by 3D-printing : comparison of image contrasts and absorbed doses in CT
Creators: name: Kunert, Patrizia
name: Schlattl, Helmut
name: Trinkl, Sebastian
name: Giussani, Augusto
name: Klein, Lea
name: Janich, Martin
name: Reichert, Detlef
name: Brix, Gunnar
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: The production of individualized anthropomorphic phantoms via three-dimensional (3D) printing methods offers promising possibilities to assess and optimize radiation exposures for specifically relevant patient groups (i.e., overweighed or pregnant persons) that are not adequately represented by standardized anthropomorphic phantoms. However, the equivalence of printed phantoms must be demonstrated exemplarily with respect to the resulting image contrasts and dose distributions. Purpose: To reproduce a conventionally produced anthropomorphic phantom of a female chest and breasts and to evaluate their equivalence with respect to image contrasts and absorbed doses at the example of a computed tomography (CT) examination of the chest. Methods: In a first step, the effect of different print settings on the CT values of printed samples was systematically investigated. Subsequently, a transversal slice and breast add-ons of a conventionally produced female body phantom were reproduced using a multi-material extrusion-based printer, considering six different types of tissues (muscle, lung, adipose, and glandular breast tissue, as well as bone and cartilage). CT images of the printed and conventionally produced phantom parts were evaluated with respect to their geometric correspondence, image contrasts, and absorbed doses measured using thermoluminescent dosimeters. Results: CT values of printed objects are highly sensitive to the selected print settings. The soft tissues of the conventionally produced phantom could be reproduced with a good agreement. Minor differences in CT values were observed for bone and lung tissue, whereas absorbed doses to the relevant tissues were identical within the measurement uncertainties. Conclusion: 3D-printed phantoms are with exception of minor contrast differences equivalent to their conventionally manufactured counterparts. When comparing the two production techniques, it is important to note that conventionally manufactured phantoms should not be considered as absolute benchmarks, as they also only approximate the human body in terms of its absorption, and attenuation of x-rays as well as its geometry.
Rituximab for treatment of inhibitors in haemophilia A: A Phase II Study
Creators: name: Josephson, Cassandra
name: Torres, Marcela
name: Raffini, Leslie
name: Saxena, Kapil
name: McCrae, Keith
name: Leissinger, Cindy
name: Journeycake, Janna
name: Key, Nigel
name: Valentino, Leonard
name: Konkle, Barbara
name: Granger, Suzanne
name: Gill, Joan
name: Manno, Catherine
name: Ragni, Margaret
name: Kruse-Jarres, Rebecca
name: Marder, Victor
name: Assmann, Susan
name: Neufeld, Ellis
name: Bennett, Carolyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates for it. The Rituximab for the Treatment of Inhibitors in Congenital Hemophilia A (RICH) study was a phase II trial to assess whether rituximab can reduce anamnestic FVIII antibody (inhibitor) titres. Male subjects with severe congenital haemophilia A and an inhibitor titre ≥5 Bethesda Units/ml (BU) following a FVIII challenge infusion received rituximab 375 mg/m2 weekly for weeks 1 through 4. Post-rituximab inhibitor titres were measured monthly from week 6 through week 22 to assess treatment response. Of 16 subjects who received at least one dose of rituximab, three (18.8%) met the criteria for a major response, defined as a fall in inhibitor titre to <5 BU, persisting after FVIII re-challenge. One subject had a minor response, defined as a fall in inhibitor titre to <5 BU, increasing to 5–10 BU after FVIII re-challenge, but <50% of the original peak inhibitor titre. Rituximab is useful in lowering inhibitor levels in patients, but its effect as a solo treatment strategy is modest. Future studies are indicated to determine the role of rituximab as an adjunctive therapy in immune tolerisation strategies.
Heisenberg Uncertainty Relation for Three Canonical Observables
Creators: name: Kechrimparis, Spiros
name: Weigert, Stefan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Uncertainty relations provide fundamental limits on what can be said about the properties of quantum systems. For a quantum particle, the commutation relation of position and momentum observables entails Heisenberg's uncertainty relation. A third observable is presented which satisfies canonical commutation relations with both position and momentum. The resulting triple of pairwise canonical observables gives rise to a Heisenberg-type uncertainty relation for the product of three standard deviations. We derive the smallest possible value of this bound and determine the specific squeezed state which saturates the triple uncertainty relation. Quantum optical experiments are proposed to verify our findings.
description: 5 pages, 2 figures. Material rearranged to match published version
Data of Dr. Xuefeng Kan, Xiaoming Yang, et al.docx
Creators: name: uwpaper, data
Publisher: name: figshare
Year: 2022
Subjects: subject: Cancer
subject: 60804 Animal Immunology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: data from study of Enhanced Efficacy of Direct Immunochemotherapy for Hepatic Cancerwith Image-Guided Intratumoral Radiofrequen Hyperthermia
Tissue factor, protease activated receptors and pathologic heart remodelling
Creators: name: Sparkenbaugh, Erica
name: Antoniak, Silvio
name: Pawlinski, Rafal
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
Symbolic dynamics for three dimensional flows with positive topological entropy
Creators: name: Lima, Yuri
name: Sarig, Omri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 37B10, 37C10 (Primary), 37C35 (Secondary)

description: We construct symbolic dynamics on sets of full measure (w.r.t. an ergodic measure of positive entropy) for $C^{1+ε}$ flows on compact smooth three-dimensional manifolds. One consequence is that the geodesic flow on the unit tangent bundle of a compact $C^\infty$ surface has at least const $\times(e^{hT}/T)$ simple closed orbits of period less than $T$, whenever the topological entropy $h$ is positive -- and without further assumptions on the curvature.
description: 50 pages, to appear in J. Eur. Math. Soc
Synthesis and crystal structures of three Schiff bases derived from 3-formyl­acetyl­acetone and benzyl-, tert-butyl- and (S)-methyl­benzyl­amine
Creators: name: Halz, Jan Henrik
name: Hentschel, Andreas
name: Wagner, Christoph
name: Merzweiler, Kurt
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Treatment of 3-formyl­acetyl­acetone with the amines benzyl­amine, tert-butyl­amine and (S)-methyl­benzyl­amine led to the formation of the corresponding Schiff bases 3-[(benzyl­amino)­methyl­idene]pentane-2,4-dione, C13H15NO2 (1), 3-[(tert-butyl­amino)­methyl­idene]pentan-2,4-dione, C10H17NO2 (2) and 3-{[(S)-benz­yl(meth­yl)amino]­methyl­idene}pentane-2,4-dione, C14H17NO2 (3). The mol­ecules of all three compounds exist as enamine tautomers that contain a nearly planar amino-methyl­ene-pentane-2,4-dione core with a strong intra­molecular N—H...O hydrogen bridge. The R group attached to the enamine N atom has no significant influence on the bond lengths and angles of the amino-methyl­ene-pentane-2,4-dione core. The supra­molecular structures in 1–3 are mainly based on weak C—H...O hydrogen bonds.
AP Corporate Training: Emprendimiento educativo para cubrir necesidades de educación técnica en Costa Rica
Creators: name: Castro, May Portuguez
Publisher: name: Zenodo
Year: 2018
Subjects: online training

description: A continuación; se presenta un proyecto de innovación educativa desarrollado en Costa Rica. Este proyecto surge para buscar cubrir las necesidades de capacitación de personas que han quedado rezagadas en el sistema educativo, especialmente por no contar con secundaria completa y que han tenido que incorporarse al sistema laboral con pocas posibilidades de crecimiento, debido especialmente a la falta de tiempo, pocas facilidades de estudio en zonas fuera de la capital o de oportunidades de capacitación en la empresa, generando menor posibilidad de aumentar sus ingresos. Es en este contexto que se desarrollan una serie de programas de formación e-learning que brindan capacitación en programas técnicos y que aprovechan los recursos de la educación a distancia para poder llegar a más personas en diferentes partes del país. La metodología de los cursos basada en el desarrollo de proyectos y la posibilidad que brindan los recursos digitales han permitido que los estudiantes además de certificar sus conocimientos en las diferentes carreras, desarrollen aportes a las empresas en las que laboran e incluso hayan desarrollado sus propios emprendimientos.
The association of α-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study
Creators: name: Cushman, Mary
name: Zhang, Yan
name: Folsom, Aaron R.
name: Rasmussen-Torvik, Laura J.
name: Heckbert, Susan R.
name: Tsai, Michael Y.
name: Rosamond, Wayne D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The α-fibrinogen Thr312Ala variant has been shown to influence clot structure through increased factor XIII cross-linking and formation of thicker fibrin fibers. However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study.
Stellar orbits in cosmological galaxy simulations: the connection to formation history and line-of-sight kinematics
Creators: name: Röttgers, Bernhard
name: Naab, Thorsten
name: Oser, Ludwig
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyze orbits of stars and dark matter out to three effective radii for 42 galaxies formed in cosmological zoom simulations. Box orbits always dominate at the centers and $z$-tubes become important at larger radii. We connect the orbital structure to the formation histories and specific features (e.g. disk, counter-rotating core, minor axis rotation) in two-dimensional kinematic maps. Globally, fast rotating galaxies with significant recent in situ star formation are dominated by $z$-tubes. Slow rotators with recent mergers have significant box orbit and $x$-tube components. Rotation, quantified by the $λ_R$-parameter often originates from streaming motion of stars on $z$-tubes but sometimes from figure rotation. The observed anti-correlation of $h_3$ and $V_0 / σ$ in rotating galaxies can be connected to a dissipative formation history leading to high $z$-tube fractions. For galaxies with recent mergers in situ formed stars, accreted stars and dark matter particles populate similar orbits. Dark matter particles have isotropic velocity dispersions. Accreted stars are typically radially biased ($β\approx 0.2 - 0.4$). In situ stars become tangentially biased (as low as $β\approx -1.0$) if dissipation was relevant during the late assembly of the galaxy. We discuss the relevance of our analysis for integral field surveys and for constraining galaxy formation models.
description: 21 pages, 19 figures
Neutrophil extracellular traps drive dacryolithiasis
Creators: name: Zlatar, Leticija
name: Timm, Thomas
name: Lochnit, Günter
name: Bilyy, Rostyslav O.
name: Bäuerle, Tobias
name: Munoz-Becerra, Marco
name: Schett, Georg
name: Knopf, Jasmin
name: Heichel, Jens
name: Javed Ali, Mohammad
name: Schapher, Mirco Lothar
name: Paulsen, Friedrich
name: Hermmann, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Mucopeptide concretions, previously called dacryoliths, are macroscopic stones that commonly obstruct the lacrimal sac. The mechanism behind dacryolithiasis remains unclear; however, the involvement of various immune cells, including neutrophils, has been confirmed. These findings remain limited, and no information on neutrophil extracellular traps (NETs), essentially involved in the pathogenesis of other lithiases, is available yet. Here, we employ microcomputed tomography, magnetic resonance tomography, histochemistry, mass spectrometry, and enzyme activity analyses to investigate the role of neutrophils and NETs in dacryolithiasis. We classify mucopeptide concretions into three types, with respect to the quantity of cellular and acellular material, polysaccharides, and mucosubstances. We propose the role of neutrophils and NETs within the existing model of gradual formation and growth of mucopeptide concretions, with neutrophils contributing to the initial stages of dacryolithiasis, as they localized on the inner (older) parts of the tissue. As NETs localized on the outer (newer) parts of the tissue, we link their role to the late stages of dacryolithiasis, presumably maintaining the proinflammatory environment and preventing efficient clearance. An abundance of IgG on the surface indicates the involvement of the adaptive immune system later as well. These findings bring new perspectives on dacryolithiasis, in which the innate and adaptive immune system are essentially involved.
Polymer inflation
Creators: name: Hassan, Syed Moeez
name: Husain, Viqar
name: Seahra, Sanjeev S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the semi-classical dynamics of a free massive scalar field in a homogeneous and isotropic cosmological spacetime. The scalar field is quantized using the polymer quantization method assuming that it is described by a gaussian coherent state. For quadratic potentials, the semi-classical equations of motion yield a universe that has an early "polymer inflation" phase which is generic and almost exactly de Sitter, followed by a epoch of slow-roll inflation. We compute polymer corrections to the slow roll formalism, and discuss the probability of inflation in this model using a physical Hamiltonian arising from time gauge fixing. We also show how in this model, it is possible to obtain a significant amount of slow-roll inflation from sub-Planckain initial data, hence circumventing some of the criticisms of standard scenarios. These results show the extent to which a quantum gravity motivated quantization method affects early universe dynamics.
description: 14 pages, 6 figures. In addition to minor changes and added references, we have included a new discussion and figure (#5) concerning the possibility of sub-Planckian initial data inducing significant slow roll inflation. Matches the version in press in PRD
Suggestion for measuring the weak dipole moment of $τ$ lepton at Z-factory
Creators: name: Xu, Qing-Jun
name: Chang, Chao-Hsi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Three new observables for Z-factory to measure the weak dipole moment of $τ$ lepton ($d_w^τ$) are proposed. As those observables employed at LEP-I, the new observables depend on the real and imaginary parts of $d_w^τ$ linearly, thus we calculate the slopes, i.e. the linear coefficients of the dependence, precisely and find that the obtained slopes are much lager than those employed at LEP-I. It means that the signal for the weak dipole moment $d_w^τ$ may be enhanced quite a lot, if one employs the new observables. Being superior to those at LEP-I, we recommend measuring the weak dipole moment $d_w^τ$ in terms of the new observables if re-analyzing the data of LEP-I or doing the measurement at a possible Z-factory in the near future.
description: 13pages, 3 figures and 1 table
Innovatón 2023
Creators: name: Nansi, García-García
Publisher: name: Zenodo
Year: 2023
Subjects: STEAM

description: Innovatón, Concurso de proyectos estudiantiles de ciencia y tecnología STEAM
 El concurso científico tecnológico para bachilleres, es una forma emocionante y efectiva de fomentar el interés en la ciencia y la tecnología, desarrollar habilidades blandas, incentivar la creatividad y la innovación, proporcionar una plataforma para compartir ideas y fomentar la colaboración.
The presence of γ′ chain impairs fibrin polymerization
Creators: name: Weisel, John W.
name: Nagaswami, Chandrasekaran
name: Gersh, Kathryn C.
name: Lord, Susan T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: A fraction of fibrinogen molecules contain an alternatively spliced variant chain called γ’. Plasma levels of this variant have been associated with both myocardial infarction and venous thrombosis. Because clot structure has been associated with cardiovascular risk, we examined the effect of γ’ chain on clot structure.
Meldrum-based-1H-1,2,3-triazoles as antidiabetic agents : synthesis, in vitro α-glucosidase inhibition activity, molecular docking studies, and in silico approach
Creators: name: Avula, Satya Kumar
name: Jan, Saeed Ullah
name: Halim, Sobia Ahsan
name: Khan, Ajmal
name: Anwar, Muhammad Usman
name: Csuk, René
name: Al-Harrasi, Ahmed
name: Rostami, Ali
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: A series of novel alkyl derivatives (2–5a,b) and 1H-1,2,3-triazole analogues (7a–k) of Meldrum’s acid were synthesized in a highly effective way by using “click” chemistry and screened for in vitro α-glucosidase inhibitory activity to examine their antidiabetic potential. 1H NMR, 13C-NMR, and high-resolution electrospray ionization mass spectra (HR-ESI-MS) were used to analyze each of the newly synthesized compounds. Interestingly, these compounds demonstrated high to moderate α-glucosidase inhibitory potency having an IC50 range of 4.63–80.21 μM. Among these derivatives, compound 7i showed extraordinary inhibitory activity and was discovered to be several times more potent than the parent compound Meldrum (1) and the standard drug acarbose. Later, molecular docking was performed to understand the binding mode and the binding strength of all the compounds with the target enzyme, which revealed that all compounds are well fitted in the active site of α-glucosidase. To further ascertain the structure of compounds, suitable X-ray single crystals of compounds 5a, 7a, and 7h were developed and studied. The current investigation has shown that combining 1H-1,2,3-triazole with the Meldrum moiety is beneficial. Furthermore, this is the first time that the aforementioned activity of these compounds has been reported.
title: Halbmond auf dem Stephansdom
Creators: name: Meßmer, Rosita Olivia Katharina Maurizia Melina
Year: 2022

description: Die Arbeit stellt die Frage nach der politischen Funktion der Grafikproduktion zu den Osmanischen Belagerungen Wiens 1529 und 1683 im zeitgenössischen Kontext und ihre Funktionalisierung im 19. Jahrhundert. Bisher wurde das Bildmaterial zu den Osmanischen Belagerungen Wiens noch nicht umfassend kunsthistorisch aufgearbeitet. Durch Untersuchung wiederkehrender Motive, wie der Stadtansicht mit Belagerung, Gräueltaten, dem Stephansturm und Triumphdarstellungen, wird untersucht, ob sich eine eigene Ikonografie der Wiener Belagerungen entwickelt. Ein weiterer Aspekt liegt dabei auf den Strategien der Fremddarstellung und des Feindbildes, die in den Darstellungen zum Tragen kommen. Das heißt auch Stereotypen und Darstellungstraditionen, auf die bei der Darstellung von Personen aus dem osmanischen Lager zurückgegriffen wird, werden untersucht. Dafür werden kritische Theorien herangezogen. Diese Fragen werden anhand von exemplarisch, aus dem reichen Quellenschatz ausgewählten, Grafiken analysiert: Holzschnitte aus dem 16. Jahrhundert, von Künstlern wie Barthel Beham, Niclas Meldeman und Hans Guldenmund, Flugblätter aus dem 17. Jahrhundert, von den Kupferstechern Jakob Müller, Johann Martin Lerch und Johann Franck, und Illustrationen aus einem Geschichtswerk von Friedrich Steinebach (1855) und aus, im Jahr 1883 zur 200. Jubiläumsfeier der Entsatzschlacht von 1683, erschienenen Zeitungen. Es ist gelungen einige bisher, nie zuvor kunsthistorisch untersuchte Blätter zu behandeln und ihre zuvor unbekannten Künstler zu identifizieren.