Could Electrical Activity Be the Key to Cancer Resistance in Certain Human Cells?
Creators: name: Rahmani, Raounak
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Cell metabolism
subject: Oncology
subject: Oncology
subject: Psycho-Oncology
subject: Cardio-Oncology
subject: Radiation Oncology
subject: Medical Oncology
subject: Surgical Oncology
subject: Integrative Oncology
subject: Oncology Nursing
subject: Surgical Oncology/economics
subject: Integrative Oncology/ethics
subject: Integrative Oncology/nursing
subject: Integrative Oncology/psychology
subject: Psycho-Oncology/education
subject: Psycho-Oncology/ethics
subject: Nuclear physics
subject: Medical biotechnology
subject: FOS: Medical biotechnology
subject: Education, Medical
subject: medical physics
subject: Cervical cancer
subject: Squamous cell carcinoma
subject: Abdominal Neoplasms/cerebrospinal fluid
subject: X-ray radiography
subject: NAD/radiation effects
subject: Genes, ras/radiation effects
subject: Neutral Red/radiation effects
subject: Biophysics
subject: Biophysics
subject: Biophysics/education
subject: Biophysical Phenomena/drug effects

description: To date, no cases of cancerous tumors have been recorded in cardiac muscle cells, inner ear cochlear cells, or nerve cells.

Each of these cell types operates based on a physical mechanism:

• Cardiac cells: The action potential occurs due to the differential distribution of ions such as Na⁺, K⁺, and Ca²⁺. When an action potential occurs, calcium enters the cell, causing contraction of the cardiac muscle fibers. Each heartbeat begins with an organized electrical signal.

• Cochlear hair cells: The cochlea contains hair cells that move in response to sound vibrations. This process leads to the opening of mechanically-gated ion channels on the cell membrane, allowing the entry of Ca²⁺ and K⁺ ions, generating an electrical potential that is converted into a neural signal.

• Neurons: These cells also regulate the movement of ions such as Na⁺, K⁺, and Cl⁻ to generate electrical signals.

 

Note: 

All three cell types share a common physical principle — they all generate a membrane potential through the movement of Na⁺, K⁺, Ca²⁺, and Cl⁻ ions, resulting in electrical signaling.

 

Hypothesis:

Is there a relationship between electrical activity, ion distribution, and the occurrence of cancer?

Could electrical activity itself be a factor that prevents mutations from transforming into cancer in cardiac cells, cochlear cells, and neurons?

 

Proposed experiment:

We isolate cardiac cells (not the whole heart), then apply calcium or potassium channel blockers to inhibit their electrical activity. After that, we expose the cells to high doses of radiation and observe the effects.

 

Does the absence of electrical activity increase the likelihood of cancer development in these cells? Is this experiment feasible or impossible?

 

In science, nothing is truly impossible — what was once unimaginable is now routine thanks to scientific and technological advancements.

Personal Note:

 

I am a Master’s student in Medical Physics, not a specialist in oncology or radiobiology. This idea emerged from a simple scientific observation and a physical reasoning process, with the hope that it may inspire a research team to explore it in depth.

 

The idea and scientific hypothesis presented are entirely my own. I used an AI writing assistant to help rephrase and format the English text

This hypothesis is the intellectual property of Rahmani Raounak, MSc student in Medical Physics. All rights reserved © 2025