title: Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ "Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ" Ð¸ "Ñ Ð»Ð¾Ð½Ð¸Ð·Ð¾Ð»" Ð² Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ ÐºÐ°Ð½ÑÐµÑÐ¾Ð¼Ð°ÑÐ¾Ð·Ð° Ð±ÑÑÑÐ½Ð¾Ð¹ Ð¿Ð¾Ð»Ð¾ÑÑÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¼Ð¸ÑÑÐ¸ÑÐµÐ½ÐºÐ¾, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÐÐµÑÑÐ¾Ð², ÐÐ¸ÐºÐ¾Ð»Ð°Ð¹ ÐÐ¸ÐºÐ¾Ð»Ð°ÐµÐ²Ð¸Ñ, 1931 - 1998
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description: ÐÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð½Ð° ÑÐµÐ¼Ñ Â«Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Â«Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑÂ» Ð¸ Â«ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð»Â» Ð² Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ ÐºÐ°Ð½ÑÐµÑÐ¾Ð¼Ð°ÑÐ¾Ð·Ð° Ð±ÑÑÑÐ½Ð¾Ð¹ Ð¿Ð¾Ð»Ð¾ÑÑÐ¸Â» Ð±ÑÐ»Ð° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ Ð¸ ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð» Ð½Ð° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÑÑ ÐºÐ°Ð½ÑÐµÑÐ¾Ð¼Ð°ÑÐ¾Ð·Ð° Ð±ÑÑÑÐ½Ð¾Ð¹ Ð¿Ð¾Ð»Ð¾ÑÑÐ¸. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ¸ ÑÐ°ÐºÐ° Ð¸ Ð¾Ð½ÐºÐ¾ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¤ÐÐÐ£ Â«ÐÐÐÐ¦ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼. Ð.Ð. ÐÐµÑÑÐ¾Ð²Ð°Â» ÐÐ¸Ð½Ð·Ð´ÑÐ°Ð²Ð° Ð Ð¾ÑÑÐ¸Ð¸. ÐÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð³Ð¸Ð¿ÐµÑÑÐµÑÐ¼Ð¸ÑÐµÑÐºÐ°Ñ Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð°Ñ Ð¿ÐµÑÑÑÐ·Ð¸Ñ Ð¸ Ð²Ð½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð°Ñ Ð¸Ð½ÑÑÐ·Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ Ð¸ ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð» Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð¿ÐµÑÐµÐ²Ð¸Ð²Ð°ÐµÐ¼ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ (ÐºÑÑÑÑ, Ð¼ÑÑÐ¸). Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½ÑÑ Ð´Ð¾ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ ÑÑÐ¸Ð»Ð¸Ð²Ð°Ð» ÑÑÑÐµÐºÑ Ð³Ð¸Ð¿ÐµÑÑÐµÑÐ¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¿ÐµÑÑÑÐ·Ð¸Ð¸, Ð½Ðµ ÑÐ¼ÐµÐ½ÑÑÐ°Ñ ÐµÐµ Ð¿ÐµÑÐµÐ½Ð¾ÑÐ¸Ð¼Ð¾ÑÑÑ, Ð² Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð¼ ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ Ð¸ ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð» Ð¾ÑÐ»Ð¸ÑÐ°Ð»Ð¸ÑÑ Ð²ÑÑÐ¾ÐºÐ¾Ð¹ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð±ÑÐ»Ð° Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð° Ñ ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð»Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ Ð¸ ÑÐ»Ð¾Ð½Ð¸Ð·Ð¾Ð» Ð² Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ð¸ ÐºÐ°Ð½ÑÐµÑÐ¾Ð¼Ð°ÑÐ¾Ð·Ð° Ð±ÑÑÑÐ½Ð¾Ð¹ Ð¿Ð¾Ð»Ð¾ÑÑÐ¸.
description: The subject of the graduate qualification work is: âExperimental investigation of anticancer agent âdioxadetâ and âchlonizolâ in intraperitoneal therapy of abdominal carcinomatosisâ. The aim of this work was to research anticancer activity of chemical agents âdioxadetâ and âchlonizolâ on experimental models of abdominal carcinomatosis. All experiments were made in the FSBI âSRC for Oncology named after N.N. Petrovâ, Ministry of Health of Russia, in the laboratory of chemoprevention of cancer and oncopharmacology. On models of transplanted tumors to experimental animals (rats, mice), hyperthermic intraperitoneal chemoperfusion and intraperitoneal infusion with âdioxadetâ and âchlonizolâ were researched, their antitumor effect was compared with the reference anticancer agent âcisplatinâ. Preclinical studies indicated the high antitumor activity of the medicine dioxadet and chlonizole in intraperitoneal therapy compared to the foreign drug cisplatin and medicine dioxadet enhanced the effect of hyperthermic intraperitoneal perfusion without decreasing its tolerability. Results obtained indicate perspective clinical researches of dioxadet and chlonizol in intraperitoneal chemotherapy of abdominal carcinomatosis.