cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Carrier-induced transition from antiferromagnetic insulator to ferromagnetic metal in the layered phosphide EuZn$_2$P$_2$
Creators: name: Chen, Xiyu
name: Yang, Wuzhang
name: Lu, Jia-Yi
name: Zhou, Zhiyu
name: Ren, Zhi
name: Cao, Guang-Han
name: Dong, Shuai
name: Wang, Zhi-Cheng
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: EuZn$_2$P$_2$ was reported to be an insulating antiferromagnet with $T_\mathrm{N}$ of 23.5 K. In this study, single crystals of EuZn$_2$P$_2$ exhibiting metallic behavior and a ferromagnetic order of 72 K ($T_\mathrm{C}$) are successfully synthesized via a salt flux method. The presence of hole carriers induced by the Eu vacancies in the lattice is found to be crucial for the drastic changes in magnetism and electrical transport. The carriers mediate the interlayer ferromagnetic interaction, and the coupling strength is directly related to $T_\mathrm{C}$, as evidenced by the linear dependence of $T_\mathrm{C}$ and the fitted Curie-Weiss temperatures on the Eu-layer distances for ferromagnetic Eu$M_2X_2$ ($M$ = Zn, Cd; $X$ = P, As). The ferromagnetic EuZn$_2$P$_2$ shows conspicuous negative magnetoresistance (MR) near $T_\mathrm{C}$, owing to strong magnetic scattering. The MR behavior is consistent with the Majumdar-Littlewood model, indicating that the MR can be enhanced by decreasing the carrier density. Our findings suggest that Eu$M_2X_2$ has highly tunable magnetism and charge transport, making it a promising material family for potential applications in spintronics.
Safety, pharmacokinetics, and pharmacodynamics of epratuzumab in Japanese patients with moderate-to-severe systemic lupus erythematosus: Results from a phase 1/2 randomized study
Creators: name: Tsuru, Tomomi
name: Tanaka, Yoshiya
name: Kishimoto, Mitsumasa
name: Saito, Kazuyoshi
name: Yoshizawa, Seiji
name: Takasaki, Yoshinari
name: Miyamura, Tomoya
name: Niiro, Hiroaki
name: Morimoto, Shinji
name: Yamamoto, Junichi
name: Rocio Lledo-Garcia
name: Shao, Jing
name: Tatematsu, Shuichiro
name: Togo, Osamu
name: Koike, Takao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Cell Biology
subject: Medicine

description: Objectives: This 12-week, randomized, double-blind, placebo-controlled, multicenter phase 1/2 study (NCT01449071) assessed the safety, pharmacokinetics, and pharmacodynamics of epratuzumab in Japanese patients with moderate-to-severe systemic lupus erythematosus despite standard of care.Methods: Twenty patients were randomized 1:1:1:1:1 to placebo or one of four epratuzumab dose regimens (100 mg every other week [Q2W], 400 mg Q2W, 600 mg every week [QW], or 1200 mg Q2W) administered during an initial 4-week dosing period. Adverse events (AEs), pharmacokinetics and pharmacodynamics were assessed.Results: Nineteen of 20 patients completed the study. All placebo patients and 13 of 16 epratuzumab patients reported ≥1 AE, 2 of 16 epratuzumab patients reported a serious AE. Cmax and AUCτ increased proportionally with dose after first and last infusion, t1/2 was similar across groups (∼13 days). Epratuzumab treatment was associated with decreased CD22 mean fluorescence intensity in total B cells (CD19+CD22+) and unswitched memory B cells (CD19+IgD+CD27+). Small-to-moderate decreases were observed in total B cell (CD20+) count.Conclusions: Epratuzumab was well-tolerated, with no new safety signals identified. The pharmacokinetics appeared linear after first and last infusions. Treatment with epratuzumab was associated with CD22 downregulation and with small-to-moderate decreases in total B cell count.
An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway
Creators: name: Jarjapu Mahita
name: K. Harini
name: Mallikarjuna Rao Pichika
name: Sowdhamini, Ramanathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Precise functioning and fine-tuning of Toll-like receptor 4 (TLR4) signaling is a critical requirement for the smooth functioning of the innate immune system, since aberrant TLR4 activation causes excessive production of pro-inflammatory cytokines and interferons. This can result in life threatening conditions such as septic shock and other inflammatory disorders. The TRIF-related adaptor molecule (TRAM) adaptor protein is unique to the TLR4 signaling pathway and abrogation of TRAM-mediated TLR4 signaling is a promising strategy for developing therapeutics aimed at disrupting TRAM interactions with other components of the TLR4 signaling complex. The VIPER motif from the vaccinia virus-producing protein, A46 has been reported to disrupt TRAM-TLR4 interactions. We have exploited this information, in combination with homology modeling and docking approaches, to identify a potential binding site on TRAM lined by the BB loop and αC helix. Virtual screening of commercially available small molecules targeting the binding site enabled to short-list 12 small molecules to abrogate TRAM-mediated TLR4 signaling. Molecular dynamics and molecular mechanics calculations have been performed for the analysis of these receptor-ligand interactions.
Diagnostic Values For Club Cell Secretory Protein (CC16) in Serum of Patients of Combined Pulmonary Fibrosis and Emphysema
Creators: name: Azuma, Arata
name: Gemma, Akihiko
name: Kokuho, Nariaki
name: Ishii, Takeo
name: Kamio, Koichiro
name: Hayashi, Hiroki
name: Kurahara, Misuzu
name: Hattori, Kumiko
name: Motegi, Takashi
name: Kozui Kida
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Marine Biology
subject: Biological Sciences
subject: Ecology
subject: Physiology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Combined pulmonary fibrosis and emphysema (CPFE) is an under-recognized syndrome for which the diagnostic use of serum biomarkers is an attractive possibility. We hypothesized that CC16 and/or TGF-β1 or combinations with other biomarkers are useful for diagnosing CPFE. Patients with respiratory symptoms and a smoking history, with or without chronic obstructive pulmonary disease, were divided into the following three groups according to findings of high-resolution computed tomography of the chest: controls without either emphysema or fibrosis, patients with emphysema alone, and patients compatible with the diagnosis of CPFE. Serum concentrations of CC16, TGF-β1, SP-D, and KL-6 were measured in patients whose condition was stable for at least 3 months. To investigate changes in biomarkers of lung fibrosis in patients with a life-long smoking history, additional measurements were performed on the patients with idiopathic pulmonary fibrosis (IPF) of smoking history. The mean age of the first three groups was 68.0 years, whereas that of the IPF group was 71.8 years, and the groups contained 36, 115, 27, and 10 individuals, respectively. The serum concentration of CC16 in the four groups was 5.67 ± 0.42, 5.66 ± 0.35, 9.38 ± 1.04 and 22.15 ± 4.64 ng/ml, respectively, indicating that those patients with lung fibrosis had a significantly higher concentration. The combined use of CC16, SP-D, and KL-6 provided supportive diagnosis in conjunction with radiological imaging in diagnosis of CPFE. We conclude that a combination of biomarkers including CC16 could provide useful information to screen and predict the possible diagnosis of CPFE.
T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise
Creators: name: Kolte, Lilian
name: Andersen, Ove
name: Dirksen, Carsten
name: Hansen, Birgitte R.
name: Haugaard, Steen B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Evolutionary Biology
subject: Cell Biology
subject: Medicine

description: In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naïve T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naïve CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naïve CD4 + T lymphocytes increased less and mature and naïve CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naïve CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.
Safety, Pharmacokinetics and Pharmacodynamics of Epratuzumab in Japanese Patients with Moderate-to-Severe Systemic Lupus Erythematosus: Results from a Phase 1/2 Randomized Study
Creators: name: Tsuru, Tomomi
name: Tanaka, Yoshiya
name: Kishimoto, Mitsumasa
name: Saito, Kazuyoshi
name: Yoshizawa, Seiji
name: Takasaki, Yoshinari
name: Miyamura, Tomoya
name: Niiro, Hiroaki
name: Morimoto, Shinji
name: Yamamoto, Junichi
name: Rocio Lledo-Garcia
name: Shao, Jing
name: Tatematsu, Shuichiro
name: Togo, Osamu
name: Koike, Takao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Cell Biology
subject: Medicine

description: Objectives: This 12-week randomized, double-blind, placebo-controlled, multicenter phase 1/2 study (NCT01449071) assessed the safety, pharmacokinetics and pharmacodynamics of epratuzumab in Japanese patients with moderate-to-severe systemic lupus erythematosus despite standard of care.Methods: Twenty patients were randomized 1:1:1:1:1 to placebo or one of four epratuzumab dose regimens (100 mg every other week [Q2W], 400 mg Q2W, 600 mg every week [QW] or 1200 mg Q2W) administered during an initial 4-week dosing period. Adverse events (AEs), pharmacokinetics and pharmacodynamics were assessed.Results: 19 out of 20 patients completed the study. All placebo patients and 13 out of 16 epratuzumab patients reported ≥1 AE, 2 out of 16 epratuzumab patients reported a serious AE. Cmax and AUCƮ increased proportionally with dose after first and last infusion, t1/2 was similar across groups (∼13 days). Epratuzumab treatment was associated with decreased CD22 mean fluorescence intensity in total B cells (CD19+CD22+) and unswitched memory B cells (CD19+IgD+CD27+). Small-to-moderate decreases were observed in total B cell (CD20+) count.Conclusions: Epratuzumab was well-tolerated, with no new safety signals identified. The pharmacokinetics appeared linear after first and last infusions. Treatment with epratuzumab was associated with CD22 downregulation and with small-to-moderate decreases in total B cell count.
title: Lettre de Jacques Leibowitch à Nathan Clumek (Hôpital Saint Pierre)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111134069930
An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway
Creators: name: Jarjapu Mahita
name: K. Harini
name: Mallikarjuna Rao Pichika
name: Sowdhamini, Ramanathan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Precise functioning and fine-tuning of Toll-like receptor 4 (TLR4) signaling is a critical requirement for the smooth functioning of the innate immune system, since aberrant TLR4 activation causes excessive production of pro-inflammatory cytokines and interferons. This can result in life threatening conditions such as septic shock and other inflammatory disorders. The TRIF-related adaptor molecule (TRAM) adaptor protein is unique to the TLR4 signaling pathway and abrogation of TRAM-mediated TLR4 signaling is a promising strategy for developing therapeutics aimed at disrupting TRAM interactions with other components of the TLR4 signaling complex. The VIPER motif from the vaccinia virus-producing protein, A46 has been reported to disrupt TRAM-TLR4 interactions. We have exploited this information, in combination with homology modeling and docking approaches, to identify a potential binding site on TRAM lined by the BB loop and αC helix. Virtual screening of commercially available small molecules targeting the binding site enabled to short-list 12 small molecules to abrogate TRAM-mediated TLR4 signaling. Molecular dynamics and molecular mechanics calculations have been performed for the analysis of these receptor-ligand interactions.
Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note
Creators: name: Smorodinova, Natalia
name: Kaltner, Herbert
name: Jirsová, Katerina
name: Hrdličková-Cela, Enkela
name: André, Sabine
name: Tomáš Kučera
name: Smetana, Karel
name: Hans-Joachim Gabius
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: Purpose: To assess the impact of Acanthamoeba keratitis (AK) and amniotic membrane transplantation (AMT) in corneal explants on presence of two multifunctional endogenous lectins, i.e. galectins-1 and -7. Methods: Ten corneal explants from AK patients (five with previous AMT and five controls without this treatment) and seven specimens of disease-free control cornea were processed by indirect fluorescent immunohistochemistry. Results: Immunostaining for both galectins was obtained in the epithelium, stroma and the endothelial layer of all controls, with the strongest positivity in the epithelium. Significantly decreased intensity for galectin-1 was recorded in the epithelium of corneal explants from patients with AK and AMT. The signal for galectin-7 was significantly decreased in the epithelium of AK patients and normalized after AMT. Conclusions: AMT has a marked impact on presence of the two galectins in opposite directions, encouraging complete profiling for this family of endogenous effectors.
Should I stay or should I go: Escape behaviour of Russell's vipers, Daboia russelii (Shaw & Nodder, 1797) in India's agricultural landscapes
Creators: name: Cyriac, Vivek P.
name: Srinivasa, Kiran B.
name: Kumar, Lohith
name: Martin, Gerard
Publisher: name: Brill Online
Year: 2022
Subjects: Ecology not elsewhere classified

description: Predation exerts a strong selective force on prey, and hence prey species have evolved a multitude of ways to escape predation. One strategy by which many mobile species escape predation is by fleeing when approached by predators. However, fleeing too early can have fitness costs. Thus, optimal escape theory suggests that escape behaviour in prey depends on the risk of being eaten and the fleeing costs. Several studies on mammals, birds and lizards lend support to this hypothesis. However, few studies have explored escape behaviour in snakes. Here, using radio telemetry to track snakes in the field, we study the escape behaviour in Russell’s vipers, a highly venomous and cryptic snake, responsible for the highest number of snakebite deaths in India. We show that escape response, i.e., the decision to stay or flee, was influenced by intrinsic factors such as the snake’s behaviour and body temperature. We also show that the flight initiation distance, the distance at which the snake flees, was mostly determined by habitat selection, i.e., the visibility of the snake and the distance to the nearest cover. Overall, we show that different factors could determine the decision to flee and when to flee. We also highlight how understanding escape response in such highly venomous, medically important yet secretive snakes could potentially help reduce human–snake encounters and mitigate the snakebite crisis.
An in-silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway
Creators: name: Jarjapu Mahita
name: K. Harini
name: Mallikarjuna Rao Pichika
name: Sowdhamini, Ramanathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Precise functioning and fine-tuning of Toll-like receptor 4 (TLR4) signaling is a critical requirement for the smooth functioning of the innate immune system, since aberrant TLR4 activation causes excessive production of pro-inflammatory cytokines and interferons. This can result in life threatening conditions such as septic shock and other inflammatory disorders. The TRIF-related adaptor molecule (TRAM) adaptor protein is unique to the TLR4 signaling pathway and abrogation of TRAM-mediated TLR4 signaling is a promising strategy for developing therapeutics aimed at disrupting TRAM interactions with other components of the TLR4 signaling complex. The VIPER motif from the vaccinia virus-producing protein, A46 has been reported to disrupt TRAM-TLR4 interactions. We have exploited this information, in combination with homology modelling and docking approaches, to identify a potential binding site on TRAM lined by the BB loop and αC helix. Virtual screening of commercially available small molecules targeting the binding site enabled to short-list 12 small molecules to abrogate TRAM-mediated TLR4 signaling. Molecular dynamics and molecular mechanics calculations have been performed for the analysis of these receptor-ligand interactions.
Chromosome number evolution, biogeography and phylogenetic relationships in Salvia (Lamiaceae)
Creators: name: Ranjbar, Massoud
name: Pakatchi, Azam
name: Babataheri, Zahra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology

description: Previous records of chromosome number for species belonging to the genus Salvia L. (Lamiaceae) are summarized and the frequency of different chromosome base numbers, the number of taxa having a particular base number, and the occurrence of aneuploidy and polyploidy in the genus are discussed. In addition, chromosome numbers and meiotic behaviour in 12 species of Salvia from Iran, S. syriaca (2n = 2x = 20), S. leriifolia (2n = 2x = 20), S. macrosiphon (2n = 2x = 20), S. reuteriana (2n = 2x = 20), S. persepolitana (2n = 2x = 20), S. palaestina (2n = 2x = 20), S. ceratophylla (2n = 2x = 22), S. atropatana (2n = 2x = 22), S. chloroleuca (2n = 2x = 22), S. hypoleuca (2n = 2x = 22), S. aethiopis (2n = 2x = 22) and S. indica (2n = 2x = 22), are presented here. Comparison of the data in the literature revealed that the variation in base numbers supports the reported polyphyletic status of the genus. The relationships between geographical distribution, chromosome numbers and ploidy levels indicate that both aneuploidy and polyploidy have played an important role in the speciation processes in Salvia.
Riluzole- and Resveratrol-Induced Delay of Retinal Ganglion Cell Death in an Experimental Model of Glaucoma
Creators: name: Pirhan, Dilara
name: Nurşen Yüksel
name: Emre, Esra
name: Cengiz, Abdulkadir
name: Yıldız, Demir Kürşat
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology
subject: Microbiology
subject: Medicine

description: Purpose: To evaluate the effects of the neuroprotective agents riluzole and resveratrol on the survival of retinal ganglion cells (RGCs) when administered alone or in combination.Materials and methods: Experimental glaucoma was induced by injecting hyaluronic acid into the anterior chamber of Wistar albino rats weekly for a six-week period. Intraocular pressure was measured before and immediately after glaucoma induction. The neuroprotective effects of daily intraperitoneal injections of riluzole (8 mg/kg) and resveratrol (10 mg/kg) were evaluated and compared. After the six-week period, dextran tetramethylrhodamine was applied into the optic nerve and the density of surviving RGCs was evaluated by counting the labeled RGCs in whole mount retinas for retrograde labeling of RGCs.Results: The mean numbers of RGCs were significantly preserved in all treatment groups compared to the vehicle-treated glaucoma group (G). The mean number of RGCs in mm2 were 1207 ± 56 in the control group (C), 404 ± 65 in G group, 965 ± 56 in riluzole-treated group in the early phase of glaucoma (E-Ri), 714 ± 25 in riluzole-treated group in the late phase of glaucoma (L-Ri), 735 ± 29 in resveratrol-treated group in the early phase of glaucoma (E-Re), 667 ± 20 in resveratrol-treated group in the late phase of glaucoma (L-Re), and 1071 ± 49 in riluzole and resveratrol combined-treated group in the early phase of glaucoma (E-RiRe group).Conclusions: When used either alone or in combination, both riluzole and resveratrol, two agents with different mechanisms of action in glaucoma, significantly delayed RGC loss in this study’s experimental glaucoma model.
Longitudinal trajectories of mental health in Australian children aged 4-5 to 14-15 years
Creators: name: Christensen, Daniel
name: Fahey, Michael
name: Giallo, Rebecca
name: Hancock, Kirsten J.
Publisher: name: Swinburne
Year: 2024

description: Mental health can affect young people’s sense of wellbeing and life satisfaction, their ability to participate in employment and education, and their onward opportunities in life. This paper offers a rare opportunity to longitudinally examine mental health in a population-representative study of children aged 4–5 years to 14–15 years. Using data from the Longitudinal Study of Australian Children (LSAC), this study examined maternally-reported child mental health over a 10 year period, in order to understand their initial mental health status early in life and its change over time, as measured by the Strengths and Difficulties Questionnaire. Longitudinal models were fitted from ages 4–5 to 14–15 years. Results showed that child sex, maternal mental health, socio-economic status (family income, maternal education, neighbourhood disadvantage), maternal hostility, and child temperament (persistence, sociability, reactivity) are all independent contributors to child mental health at age 4. These effects largely persist over time, with the effects of maternal mental health increasing slightly over time. Persistence of these effects suggests the need for early intervention and supports. The independent contribution of these factors to child mental health suggests that multi-faceted approaches to child and maternal mental health are needed.
Transition-Metal-Free C–S Bond Formation: Aqueous Synthesis of S-Aryl Dithiocarbamates by The use of Stable Arenediazonium Salts Mediated by Nano-Magnetic Supported Silica Sulfonic Acid
Creators: name: Firouzeh Nemati
name: Elhampour, Ali
name: Zulfaghari, Soghra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Biochemistry

description: GRAPHICAL ABSTRACT
Assessment of cholesterol level among patient with hypertension in Bosassa district Puntiland, somalia, 2023
Creators: name: Hibaaq, Abdihakiim Hassan
Publisher: name: Zenodo
Year: 2025
Subjects: Assessment of cholesterol level
among patient with hypertension in Bosassa district Puntiland, somalia, 2023

description: Abstract

Cholesterol is a fatty acid (lipid) essential to a healthy life. It is located in the brain, nervous tissue, skin, and adrenal glands. It has main functions within the human body. It is used in the structure of all cell membranes and to produce bile acid, which aids digestion and absorption of fats in the diet.
The Public Health and Economic Impact of Drug Overdose Out-of-Hospital Cardiac Arrest in the United States
Creators: name: Coute, Ryan A.
name: Nathanson, Brian H.
name: Shekhar, Aditya C.
name: White, Christopher N.
name: Kurz, Michael C.
name: Jackson, Elizabeth A.
name: Mader, Timothy J.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Science Policy
Hematology
Computational Biology

description: To calculate disability-adjusted life years (DALY) and labor productivity loss due to drug overdose out-of-hospital cardiac arrest (DO-OHCA) and compare its contribution to the burden of disease and economic impact of all-cause nontraumatic out-of-hospital cardiac arrest (OHCA) in the US. We performed a retrospective observational cohort analysis of all adult (age ≥18 years) nontraumatic emergency medical services-treated OHCA events, including those due to DO-OHCA, from the national Cardiac Arrest Registry to Enhance Survival (CARES) database from January 1, 2017 and December 31, 2020. The main outcome measures of interest were disability-adjusted life years, annual, and lifetime labor productivity loss over the 4-year study period. The findings for the study population were extrapolated to a national level using the CARES population catchment and U.S. population estimates by year. A total of 378,088 adult OHCA events, including 23,252 DO-OHCA (6.2%) met study inclusion criteria. The DO-OHCA DALY increased from 156,707 in 2017 to 265,692 in 2020. Per year, DO-OHCA contributed to 11.4%, 12.0%, 10.5%, and 11.4% of all OHCA DALY lost from 2017-2020, respectively. The mean annual and lifetime productivity losses for all OHCA were stable over time (annual: $47K in 2017 to $50K in 2020; lifetime: $647K in 2017 to $692K in 2020). The CARES population catchment increased by 39.8% over the study period (102.6 M in 2017 to 143.4 M in 2020). For DO-OHCA, the mean annual productivity loss was approximately 30% higher than non-DO-OHCA ($64K vs. $49K in 2020, respectively). The mean lifetime productivity loss for DO-OHCA was 2.5 times higher than non-DO-OHCA ($1.6 M vs. $630K in 2020, respectively). The DALY due to DO-OHCA has increased over time with expansion of the CARES dataset, but its relative contribution to total OHCA DALY (all non-traumatic etiologies) remained fairly stable. The DO-OHCAs represent approximately 6% of all adult non-traumatic EMS-treated OHCA events but has a disproportionately greater economic impact. Continued efforts to reduce DO-OHCA through public health initiatives are warranted to lessen the societal impact of OHCA in the U.S.
Synthesis and structural Studies of phosphonothioamidates
Creators: name: R. Omrani
name: F. Ben Amor
name: M. Bahri
name: M. L. Efrit
name: A. Ben Akacha
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
Conflict in Men’s Experiences With Antidepressants
Creators: name: Gibson, Kerry
name: Cartwright, Claire
name: Read, John
Publisher: name: Swinburne
Year: 2024

description: While men’s experiences of depression and help seeking are known to be shaped by gender, there is little research which examines their experience of using antidepressants to treat this. This study is based on in-depth, narrative-style interviews with 20 New Zealand men who had used antidepressants. The analysis identified a number of areas of conflict in the men’s accounts of using this medication. Conflict centered on the way taking antidepressants was seen as undermining personal control while also allowing users to take charge of their problems; facilitating general functioning while undermining sexual functioning; relieving emotional distress while undermining emotional vitality; and the tension participants felt between making autonomous judgments about the value of antidepressants and relying on the “expertise” of others. Participants negotiated these conflicts in a variety of ways. In some cases, antidepressants were positioned as being able to affirm aspects of traditional masculinity, while a smaller number of participants managed these conflicts by redefining aspects of their own masculinity in ways that contrasted with dominant constructions. This research is limited by the sample of older, more privileged men in the context of New Zealand culture which favors macho forms of masculinity. In similar contexts, mental health practitioners should be mindful of the conflicts that men might experience in relation to their antidepressant use. Facilitating men’s exploration of these issues may enable them to make better decisions about treatment options or to provide more effective support to those who have opted for antidepressant treatment.
Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism
Creators: name: Vikineswary Sabaratnam
name: Chia-Wei Phan
name: David, Pamela
name: Murali Naidu
name: Kah-Hui Wong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Cell Biology
subject: Microbiology

description: Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer’s and Parkinson’s diseases. Therefore, efforts have been devoted to a search for more mushroom species that may improve memory and cognition functions. Such mushrooms include Hericium erinaceus, Ganoderma lucidum, Sarcodon spp., Antrodia camphorata, Pleurotus giganteus, Lignosus rhinocerotis, Grifola frondosa, and many more. Here, we review over 20 different brain-improving culinary-medicinal mushrooms and at least 80 different bioactive secondary metabolites isolated from them. The mushrooms (either extracts from basidiocarps/mycelia or isolated compounds) reduced beta amyloid-induced neurotoxicity and had anti-acetylcholinesterase, neurite outgrowth stimulation, nerve growth factor (NGF) synthesis, neuroprotective, antioxidant, and anti-(neuro)inflammatory effects. The in vitro and in vivo studies on the molecular mechanisms responsible for the bioactive effects of mushrooms are also discussed. Mushrooms can be considered as useful therapeutic agents in the management and/or treatment of neurodegeneration diseases. However, this review focuses on in vitro evidence and clinical trials with humans are needed.
A One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using pph3/n-chlorobenzotriazole system
Creators: name: Rouhi-Saadabad, Hamed
name: Batool Akhlaghinia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Engineering

description: GRAPHICAL ABSTRACT
Student teachers and epistemic beliefs and emotions
Creators: name: Peiser, Gillian
name: Putwain, David W.
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390499
subject: Specialist studies in education not elsewhere classified

description: This data set contains:(1) an SPSS file with raw data from survey study(2) PDF copy of online survey(3) Mplus input files(4) MS Word file with results of tests conducted using SPSS and further detail of latent profile analysis.
The SPSS file contains the responses to a survey study (n=376), that gathered data from student teachers on different initial teacher education courses in England that addressed the following research question:
Are there differences in student teachers' epistemic beliefs and epistemic emotions relating to educational research between • females and males,• students following university-led and school-led ITE routes,• primary and secondary student teachers,• postgraduate and undergraduate student teachers?
The MS Word file provides the results of tests conducted to investigate statistically significant correlations between different demographics and epistemic beliefs and emotions.
This MS Word file contains: (1) independent samples t-test outputs which investigated correlations and statistical significance between epistemic beliefs and emotions with student teachers' gender, initial teacher education pathway, subject specialism and ages;(2) A summary table of statistically significant results from (1)(3) One-way between-subjects ANOVA results for primary undergraduate, primary postgraduate and secondary postgraduate students;(4) Bi-variate correlations between different epistemic beliefs and emotions;(5) Internal consistency estimates for the five domains of epistemic beliefs and emotions.
In addition, the study aimed to investigate whether distinct profiles of student teachers emerged based on different epistemic beliefs and emotions and whether profile indicators correlated with demographic differences.
The M Plus input files used for latent profile analysis are provided, in addition to the four profile outputs with co-variates. Further details about the MPlus data analysis are provided within the MS Word document to supplement those in the linked journal paper.
The sleep and circadian modulation of neural reward pathways: A protocol for a pair of systematic reviews
Creators: name: Byrne, Jamie E.M.
name: Murray, Greg
Publisher: name: Swinburne
Year: 2024

description: Background: Animal research suggests that neural reward activation may be systematically modulated by sleep and circadian function. Whether humans also exhibit sleep and circadian modulation of neural reward pathways is unclear. This area is in need of further research, as it has implications for the involvement of sleep and circadian function in reward-related disorders. The aim of this paper is to describe the protocol for a pair of systematic literature reviews to synthesise existing literature related to (1) sleep and (2) circadian modulation of neural reward pathways in healthy human populations.
Methods: A systematic review of relevant online databases (Scopus, PubMed, Web of Science, ProQuest, PsycINFO and EBSCOhost) will be conducted. Reference lists, relevant reviews and supplementary data will be searched for additional articles. Articles will be included if (a) they contain a sleep- or circadian-related predictor variable with a neural reward outcome variable, (b) use a functional magnetic resonance imaging protocol and (c) use human samples. Articles will be excluded if study participants had disorders known to affect the reward system. The articles will be screened by two independent authors. Two authors will complete the data extraction form, with two authors independently completing the quality assessment tool for the selected articles, with a consensus reached with a third author if needed. Narrative synthesis methods will be used to analyse the data.
Discussion: The findings from this pair of systematic literature reviews will assist in the identification of the pathways involved in the sleep and circadian function modulation of neural reward in healthy individuals, with implications for disorders characterised by dysregulation in sleep, circadian rhythms and reward function.
Systematic review registration: PROSPERO CRD42017064994
title: Coral and Fish Community Development on Artificial Reefs of Different Ages in Bali
title: Expectations from Ecological Theory
titleType: Subtitle
Creators: name: Osborne, Kyle
Publisher: name: Lancaster University
Year: 2022

description: Many severely degraded coral reefs around the world show no signs of natural recovery, even decades after the disturbances were eliminated. In these degraded reefs the lack of suitable substrate and high post-settlement mortality inhibits coral recolonisation and recovery. In reef sites where the physical structure is lost, restoration efforts aim to provide a fixed substrate, either for natural coral settlement or for the transplantation of coral fragments. Artificial reefs have been designed and developed to be used as a coral reef conservation tool for habitat restoration in disturbed coral reefs. Here, the extent to which an artificial reef can provide a habitat for reef species and support coral recruitment was assessed using a model system of artificial reefs in Bali deployed over six-month intervals for up to 3.5 years. A generally positive trend of coral community development was recorded, including increased coral size, density, cover, and richness on artificial reefs with increasing time since deployment. This change over time can be explained by the facilitation model of ecological theory while metacommunity theory can be applied to explain differences between artificial and natural reef communities. However, fish densities in the artificial reef were significantly lower than in the natural reef, were not significantly different to the adjacent sand sites, and did not change over time. Despite significant differences in coral and fish populations between the artificial reefs and adjacent natural reefs, the trajectory of corals at this stage is encouraging. Previous studies on artificial reefs have estimated it may take between 10-20 years for an artificial reef to re-establish the structure and function of a natural reef. Currently there are no published records describing reef restoration outcomes over such timeframes, making the establishment of this baseline and future long-term monitoring of the artificial reef important contributions to the field.
D2.5 - MLOs Beta Release
Creators: name: Sarkar, Arkopaul
Publisher: name: Zenodo
Year: 2024
Subjects: Alignment
Data
Harmonization
Ontology
Standardisation

description: OntoCommons aims at working toward interoperability by means of harmonization with respect to upperlevel ontologies and facilitating agreement in domain ontology development. As part of the effort of work package 2, an objective of OntoCommons is to provide alignments among existing MLOs from different TLO branches. This task needs to perform several activities, such as identification of existing MLOs and corresponding disciplines that are to be covered by the alignment effort, the definition of the expected level of alignment that is to be performed for the MLOs and finding gaps in the disciplines which may be filled with new MLO development. A beta version of the harmonized MLO is planned to be published in the 18th month of the project. This report associates the current development and describes the methodology, list of disciplines and MLOs considered and other technical details.
title: Ведение расчетов с бюджетом и внебюджетными фондами
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: В учебном пособии кратко изложен теоретический материал, в котором рассмотрены основы проведения расчета с бюджетом и внебюджетными фондами, основы налогового регулирования, федеральные, региональные и местные налоги, специальные налоговые режимы. Освещены организация расчетов с внебюджетными фондами: страховые взносы в Фонд социального и пенсионного страхования (Социальный фонд России), Федеральный и территориальный фонды обязательного медицинского страхования, их экономическая сущность, а также взносы на страхование от несчастных случаев на производстве и профессиональных заболеваний. Теоретический материал дополнен практическими заданиями, контрольными вопросами, тестами и темами докладов (рефератов), а также списком литературы по каждой теме. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, обучающихся по укрупненной группе специальностей и направлений подготовки высшего образования «Экономика и управление», изучающих дисциплину «Ведение расчетов с бюджетом и внебюджетными фондами».
Fast analysis of volatile components of Achillea tenuifolia Lam with microwave distillation followed by headspace single-drop microextraction coupled to gas chromatography-mass spectrometry (GC–MS)
Creators: name: Piryaei, Marzieh
name: Nazemiyeh, Hossein
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: This article investigates the effect of microwaves on the amount of volatile compounds Achillea tenuifolia Lam with two methods, headspace single-drop microextraction and microwave-assisted headspace single-drop microextraction (MA-SDME), for the analysis of essential oil. Solvent selection, solvent volume, microwave power, irradiation time and sample mass were optimised by the simplex method.
Synthesis and Structural Studies of Phosphonothioamidates
Creators: name: R. Omrani
name: F. Ben Amor
name: M. Bahri
name: M. L. Efrit
name: A. Ben Akacha
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
Connecting through public transport: accessibility to health and education in major African cities
Creators: name: Stokenberga, Aiga
name: Saïsset, Eulalie
name: Kerzhner, Tamara
name: Alegre, Xavier Espinet
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Transport matters for health and education outcomes, by ensuring physical access to crucial facilities. Using spatial modelling techniques and routable public transport service data, this study assesses the effectiveness of mostly semi fixed-route public transport systems in connecting people to advanced healthcare and education facilities in African cities. Uncovering significant pockets of ‘accessibility poverty’ – travel times above an acceptable level – it underscores the inequality in access within the cities, disproportionately affecting poor populations. Proximity of public transport to homes matters but has limited impact, due to how the routes, operated mainly by informal service providers, are allocated across the urban space and the low technical performance. The low ‘value added’ of public transport compared to walking helps explain the prevalence of foot travel. Tailored policy interventions – improving the public transport systems and, equally importantly, ensuring more equitable spatial distribution of advanced healthcare facilities – emerge as crucial strategies for addressing accessibility poverty.
Transition-Metal-Free C–S Bond Formation: Aqueous Synthesis of S-Aryl Dithiocarbamates by the Use of Stable Arenediazonium Salts Mediated by Nano-magnetic Supported Silica Sulfonic Acid
Creators: name: Firouzeh Nemati
name: Elhampour, Ali
name: Zulfaghari, Soghra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Biochemistry

description: GRAPHICAL ABSTRACT
Tracking the follow-up of work in progress papers
Creators: name: Mubin, Omar
name: Arsalan, Mudassar
name: Al Mahmud, Abdullah
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 460806
subject: Human-computer interaction

description: Academic conferences offer numerous submission tracks to support the inclusion of a variety of researchers and topics. Work in progress papers are one such submission type where authors present preliminary results in a poster session. They have recently gained popularity in the area of Human Computer Interaction (HCI) as a relatively easier pathway to attending the conference due to their higher acceptance rate as compared to the main tracks. However, it is not clear if these work in progress papers are further extended or transitioned into more complete and thorough full papers or are simply one-off pieces of research. In order to answer this we explore self-citation patterns of four work in progress editions in two popular HCI conferences (CHI2010, CHI2011, HRI2010 and HRI2011). Our results show that almost 50% of the work in progress papers do not have any self-citations and approximately only half of the self-citations can be considered as true extensions of the original work in progress paper. Specific conferences dominate as the preferred venue where extensions of these work in progress papers are published. Furthermore, the rate of self-citations peaks in the immediate year after publication and gradually tails off. By tracing author publication records, we also delve into possible reasons of work in progress papers not being cited in follow up publications. In conclusion, we speculate on the main trends observed and what they may mean looking ahead for the work in progress track of premier HCI conferences.