cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Creators: name: Sparta, Dennis R.
name: Stamatakis, Alice M.
name: Zhang, Feng
name: Tye, Kay M.
name: Deisseroth, Karl
name: Stuber, Garret D.
name: van Leeuwen, Wieke A.
name: Hardjoprajitno, Juanita E.
name: Cho, Saemi
name: Bonci, Antonello
name: Kempadoo, Kimberly A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Interactions between the basolateral amygdala (BLA) and nucleus accumbens (NAc) are involved in a number of reward-processing and addictive behaviours, but our understanding of the precise role of each of these brain areas has been limited by the inability to manipulate pathways selectively during behaviour. Stuber et al. use optogenetic technologies, in which light selectively activates or inhibits genetically-defined neuronal subpopulations, to reveal an unexpected role for the BLA a brain region usually associated with aversive behaviours. The BLA is shown to be important for processing both positive and negative effects, but glutamatergic pathways between the BLA and NAc are specifically associated with reward-seeking behaviours.
Contaminazioni e degrado del linguaggio giuridico: riflessi su principio di affidamento, certezza del diritto e partecipazione democratica
Creators: name: Ciocia, Paolo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2023
Subjects: IUS/20 Filosofia del diritto

description: [Contamination and degradation of legal language: reflections on the principle of trust, legal certainty and democratic participation]. The legal text must clearly communicate the legal rule. The ease of understanding of the rule by citizens is the condition for its effectiveness and legal certainty. The primary assumption of comprehensibility is the existence of a strong link with the matrix of common language. In Italy the legal language, for many reasons, is complex, imprecise, full of terms of other languages, increasingly distant from common language. A clear legal rule allows the citizen’s understanding, certainty and participation in democratic life.
Capillary surfaces of constant mean curvature in a right solid cylinder
Creators: name: López, Rafael
name: Pyo, Juncheol
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: In this paper we investigate constant mean curvature surfaces with nonempty boundary in Euclidean space that meet a right cylinder at a constant angle along the boundary. If the surface lies inside of the cylinder, we obtain some results of symmetry by using the Alexandrov reflection method. When the mean curvature is zero, we give sufficient conditions to obtain that the surface is part of a plane or a catenoid.
Electronic Instabilities of the AA-Honeycomb Bilayer
Creators: name: de la Peña, David Sánchez
name: Scherer, Michael M.
name: Honerkamp, Carsten
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use a functional renormalization group approach to study the instabilities due to electron-electron interactions in a bilayer honeycomb lattice model with AA stacking, as it might be relevant for layered graphene with this structure. Starting with a tight- binding description for the four $π$-bands, we integrate out the modes of the dispersion by successively lowering an infrared cutoff and determine the leading tendencies in the effective interactions. The antiferromagnetic spin-density wave is an expected instability for dominant local repulsion among the electrons, but for nonlocal interaction terms also other instabilities occur. We discuss the phase diagrams depending on the model parameters. We compare our results to single-layer graphene and the more common AB-stacked bilayer, both qualitatively and quantitatively.
description: 9 pages, 3 figures, Annalen der Physik, online available (2014)
Integrated genomic analyses of ovarian carcinoma
Creators: name: Morrison, C.
name: Glenn, P.
name: Birrer, M.
name: Petrelli, N.
name: Karlan, B. Y.
name: Huang, M.
name: Gross, J.
name: Rabeno, B.
name: Sood, A. K.
name: Olvera, N.
name: Mills, G. B.
name: Rader, J. S.
name: Cramer, D. W.
name: Godwin, A. K.
name: Huntsman, D. G.
name: Berchuck, A.
name: Imielinski, M.
name: DiSaia, P.
name: Kalloger, S.
name: Bell, D.
name: Mutch, D.
name: Sikic, B. I.
name: Chien, J.
name: Smith-McCune, K.
name: Dhir, R.
name: Orsulic, S.
name: Gabra, H.
name: Park, K.
name: Dao, F.
name: Levine, D. A.
name: Iacocca, M.
name: Hartmann, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: SummaryThe Cancer Genome Atlas (TCGA) project has analyzed mRNA expression, miRNA expression, promoter methylation, and DNA copy number in 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa) and the DNA sequences of exons from coding genes in 316 of these tumors. These results show that HGS-OvCa is characterized by TP53 mutations in almost all tumors (96%); low prevalence but statistically recurrent somatic mutations in 9 additional genes including NF1, BRCA1, BRCA2, RB1, and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three miRNA subtypes, four promoter methylation subtypes, a transcriptional signature associated with survival duration and shed new light on the impact on survival of tumors with BRCA1/2 and CCNE1 aberrations. Pathway analyses suggested that homologous recombination is defective in about half of tumors, and that Notch and FOXM1 signaling are involved in serous ovarian cancer pathophysiology.
Interpreting the extended emission around three nearby debris disc host stars
Creators: name: Marshall, Jonathan P.
name: Kirchschlager, F.
name: Ertel, S.
name: Augereau, J. -C.
name: Kennedy, G. M.
name: Booth, M.
name: Wolf, S.
name: Montesinos, B.
name: Eiroa, C.
name: Matthews, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Cool debris discs are a relic of the planetesimal formation process around their host star, analogous to the solar system's Edgeworth-Kuiper belt. As such, they can be used as a proxy to probe the origin and formation of planetary systems like our own. The Herschel Open Time Key Programmes "DUst around NEarby Stars" (DUNES) and "Disc Emission via a Bias-free Reconnaissance in the Infrared/Submillimetre" (DEBRIS) observed many nearby, sun-like stars at far-infrared wavelengths seeking to detect and characterize the emission from their circumstellar dust. Excess emission attributable to the presence of dust was identified from around $\sim$ 20% of stars. Herschel's high angular resolution ($\sim$ 7" FWHM at 100 $μ$m) provided the capacity for resolving debris belts around nearby stars with radial extents comparable to the solar system (50 to 100 au). As part of the DUNES and DEBRIS surveys, we obtained observations of three debris disc stars, HIP 22263 (HD 30495), HIP 62207 (HD 110897), and HIP 72848 (HD 131511), at far-infrared wavelengths with the Herschel PACS instrument. Combining these new images and photometry with ancilliary data from the literature, we undertook simultaneous multi-wavelength modelling of the discs' radial profiles and spectral energy distributions using three different methodologies: single annulus, modified black body, and a radiative transfer code. We present the first far-infrared spatially resolved images of these discs and new single-component debris disc models. We characterize the capacity of the models to reproduce the disc parameters based on marginally resolved emission through analysis of two sets of simulated systems (based on the HIP 22263 and HIP 62207 data) with the noise levels typical of the Herschel images. We find that the input parameter values are recovered well at noise levels attained in the observations presented here.
description: 13 pages, 5 figures, 5 tables, accepted for publication in A&A
Additional file 2 of Comparative genome analysis unravels pathogenicity of Xanthomonas albilineans causing sugarcane leaf scald disease
Creators: name: Li, MeiLin
name: Bao, YiXue
name: Li, YiSha
name: Akbar, Sehrish
name: Wu, GuangYue
name: Du, JinXia
name: Wen, Ronghui
name: Chen, Baoshan
name: Zhang, MuQing
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table S1. Basic information of Xal JG43 and Xsa DD13. Table S2. Repeat contents from genome sequence of Xal JG43 and Xsa DD13. Table S3. Genes in plasmid from the genome of Xal JG43. (.xls ) Table S4. Carbohydrate-active enzymes (CAZys) in Xal JG43 and Xsa DD13. Table S5. Comparative pathogenomics of X. albilineans JG43 and its related X. sacchari DD13. (.xls ) Table S6. Genomic island and prophages of Xal JG43 and Xsa DD13. (.xls ) Table S7. Resequencing of 23 X. albilineans strains. Table S8. Genomic variations (SNPs and SVs) obtained from 23 sequenced X. albilineans strains against JG43. Table S9. SNP mutations in 23 strains of X. albilineans. Table S10. Mutations at the DNA level in 23 strains of X. albilineans. Table S11. List of primers used in this study.
Suppression of lung adenocarcinoma progression by Nkx2-1
Creators: name: Jacks, Tyler
name: Hoersch, Sebastian
name: Bronson, Roderick T.
name: Meyerson, Matthew
name: Snyder, Eric L.
name: Winslow, Monte M.
name: Kim-Kiselak, Caroline
name: Verhaak, Roel G. W.
name: Whittaker, Charles A.
name: Chiang, Derek Y.
name: Crowley, Denise
name: Hubbard, Diana D.
name: Yoon, Stephanie
name: DuPage, Michel J.
name: Dayton, Talya L.
name: Feldser, David M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-pathway2, using conditional alleles in mice3–5. Lentiviral-mediated somatic activation of oncogenic Kras and deletion of p53 in the lung epithelial cells of KrasLSL-G12D/+;p53flox/flox mice initiates lung adenocarcinoma development4. Although tumours are initiated synchronously by defined genetic alterations, only a subset become malignant, suggesting that disease progression requires additional alterations. Identification of the lentiviral integration sites allowed us to distinguish metastatic from non-metastatic tumours and determine the gene expression alterations that distinguish these tumour types. Cross-species analysis identified the NK-2 related homeobox transcription factor Nkx2-1 (Ttf-1/Titf1) as a candidate suppressor of malignant progression. In this mouse model, Nkx2-1-negativity is pathognomonic of high-grade poorly differentiated tumours. Gain-and loss-of-function experiments in cells derived from metastatic and non-metastatic tumours demonstrated that Nkx2-1 controls tumour differentiation and limits metastatic potential in vivo. Interrogation of Nkx2-1 regulated genes, analysis of tumours at defined developmental stages, and functional complementation experiments indicate that Nkx2-1 constrains tumours in part by repressing the embryonically-restricted chromatin regulator Hmga2. While focal amplification of NKX2-1 in a fraction of human lung adenocarcinomas has focused attention on its oncogenic function6–9, our data specifically link Nkx2-1 downregulation to loss of differentiation, enhanced tumour seeding ability, and increased metastatic proclivity. Thus, the oncogenic and suppressive functions of Nkx2-1 in the same tumour type substantiate its role as a dual function lineage factor.
Albiella Lundblad 1971
Creators: name: Smit, Harry
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Aturidae
Albiella

description: Subgenus Albiella Lundblad, 1971
The subgenus has mainly an Oriental and Australasian distribution, with 6 species known from Australia (Smit 2012b), 10 from New Guinea (one shared with Australia, Wiles 1992, Smit 2013), one from Java, two from Sulawesi, one from Borneo (Wiles 1992, 1999, Smit 1996), one from India (Wiles 1992) and one odd record from The Netherlands (Smit & Van der Hammen 1992).
description: Published as part of Smit, Harry & Pešić, Vladimir, 2014, Water mites from Mount Kinabalu and the Crocker Range, Borneo, Malaysia (Acari: Hydrachnidia), with the description of 34 new species, pp. 1-71 in Zootaxa 3876 (1) on page 62, DOI: 10.11646/zootaxa.3876.1.1, http://zenodo.org/record/287281
The genome of the green anole lizard and a comparative analysis with birds and mammals
Creators: name: Grabherr, Manfred
name: Fujita, Matthew K.
name: Russell, Pamela
name: Jaffe, Jacob D.
name: Mauceli, Evan
name: Pollock, David D.
name: Novick, Peter A.
name: Lowe, Craig B.
name: Koriabine, Maxim Y.
name: Haussler, David
name: ten Hallers, Boudewijn F.
name: Shedlock, Andrew M.
name: Peach, Sally E.
name: Moreno, Ricardo Godinez
name: Colbourne, John K.
name: Glor, Richard E.
name: Boissinot, Stephane
name: Poe, Steven
name: Kong, Lesheng
name: Lara, Marcia
name: Janes, Daniel E.
name: Di Palma, Federica
name: Castoe, Todd A.
name: Williams, Christina
name: Heiman, David
name: Ray, David A.
name: Alföldi, Jessica
name: Botka, Christopher
name: Johnson, Jeremy
name: Heger, Andreas
name: de Jong, Pieter J.
name: Organ, Chris L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments1. Among amniotes, genome sequences are available for mammals2 and birds3–5, but not for non-avian reptiles. Here we report the genome sequence of the North American green anole lizard, Anolis carolinensis. We find that A. carolinensis microchromosomes are highly syntenic with chicken microchromosomes, yet do not exhibit the high GC and low repeat content that are characteristic of avian microchromosomes3. Also, A. carolinensis mobile elements are very young and diverse – more so than in any other sequenced amniote genome. This lizard genome’s GC content is also unusual in its homogeneity, unlike the regionally variable GC content found in mammals and birds6. We describe and assign sequence to the previously unknown A. carolinensis X chromosome. Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations.
La criptovaluta, un circuito economico alternativo. Applicazioni e prospettive di sviluppo nell'economia nazionale e la necessità di una regolamentazione complessiva
Creators: name: Bochicchio, Carla
Publisher: name: Universita degli studi di Salerno
Year: 2023
Subjects: subject: IUS/04 DIRITTO COMMERCIALE
subject: Criptovaluta

description: Il presente lavoro si occupa del fenomeno delle criptovalute, fenomeno senza dubbio di nuova generazione. Il primo capitolo riguarda l’origine della criptovaluta, e anche di bitcoin, che rappresenta la criptovaluta più famosa e senz’altro la più diffusa, tanto da costituirne il prototipo. L’interesse che l’argomento ha suscitato dipende anche dal fatto che il sistema monetario e finanziario sta cambiando nella sua forma tradizionale, e di fronte a tale trasformazione la criptovaluta secondo alcuni è la soluzione secondo altri è solo un ulteriore problema. Alcuni studiosi hanno addirittura propugnato una visione per così dire messianica, arrivando a paragonare Satoshi Nakamoto, il misterioso capostipite del fenomeno criptocurrency, a Martin Lutero1 : come il monaco agostiniano ha affrancato l’umanità dall’intermediazione del clero, similmente il padre del bitcoin l’avrebbe liberata dal controllo delle banche centrali, gettando le basi per un sistema economico democratico e paritetico ( “peerto peer”) fondato sul ricorso a mezzo di pagamento alternativo alla moneta tradizionale. La ragione sottesa alla creazione del fenomeno bitcoin, rectius delle criptovaluta in generale, risiede nell’insoddisfazione e nell’assoluta sfiducia degli investitori e dei risparmiatori nelle Istituzioni bancarie, soprattutto in seguito alla crisi finanziaria del 2008, pertanto, ai fini di una comprensione, il più possibile chiara del sistema economico alternativo che il presente lavoro mira a delineare, è necessario partire dalle origini. .. [introduzione a cura dell'Autore]
The Trotter Step Size Required for Accurate Quantum Simulation of Quantum Chemistry
Creators: name: Poulin, David
name: Hastings, M. B.
name: Wecker, Dave
name: Wiebe, Nathan
name: Doherty, Andrew C.
name: Troyer, Matthias
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The simulation of molecules is a widely anticipated application of quantum computers. However, recent studies \cite{WBCH13a,HWBT14a} have cast a shadow on this hope by revealing that the complexity in gate count of such simulations increases with the number of spin orbitals $N$ as $N^8$, which becomes prohibitive even for molecules of modest size $N\sim 100$. This study was partly based on a scaling analysis of the Trotter step required for an ensemble of random artificial molecules. Here, we revisit this analysis and find instead that the scaling is closer to $N^6$ in worst case for real model molecules we have studied, indicating that the random ensemble fails to accurately capture the statistical properties of real-world molecules. Actual scaling may be significantly better than this due to averaging effects. We then present an alternative simulation scheme and show that it can sometimes outperform existing schemes, but that this possibility depends crucially on the details of the simulated molecule. We obtain further improvements using a version of the coalescing scheme of \cite{WBCH13a}; this scheme is based on using different Trotter steps for different terms. The method we use to bound the complexity of simulating a given molecule is efficient, in contrast to the approach of \cite{WBCH13a,HWBT14a} which relied on exponentially costly classical exact simulation.
description: 13 pages, 7 figures
Additional file 1 of Prospective sampling bias in COVID-19 recruitment methods: experimental evidence from a national randomized survey testing recruitment materials
Creators: name: Kennedy, Eric B.
name: Charifson, Mia
name: Jehn, Megan
name: Jensen, Eric A.
name: Vikse, Jenna
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table SM.1. Expected (based on population) versus actual count of households receiving postcards. Fig. SM.1. “COVID Specific” postcard design. Fig. SM.2. “General Health” postcard design. Table SM.2. Descriptive characteristics of study sample by postcard type. Table SM.3. Likelihood of Agreeing with the statement: “Getting sick with COVID-19 can be serious.” Table SM.4. Likelihood of Agreeing with the statement: “I will probably get COVID-19.” Table SM.5. Likelihood of Agreeing with the statement: “The threat posed by COVID-19 is exaggerated by the Canadian federal government.” Table SM.6. Likelihood of Agreeing with the statement: “COVID-19 will NOT affect many Canadians.”.
Release and bioavailability of dissolved organic matter from floodplain litter: influence of origin and oxygen levels
Creators: name: O'Connell, M
name: Baldwin, D. S
name: Robertson, A. I
name: Rees, G
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

1. We determined the rate of release and microbial uptake of dissolved organic carbon (DOC) leached from three components (leaves, bark and twigs) of river red gum (Eucalyptus camaldulensis) forest litter originating from different parts of a floodplain and under different oxygen levels.2. Preliminary experiments showed that substantially more DOC was released from leaves than from bark or twigs; there was relatively little DOC release from coarse particulate matter or soil.3. Both the amount of DOC released from each litter component and the amount metabolized by the microbial community were independent of position on the flood-plain or amount of oxygen available to microbes.4. Although the bioavailability of DOC was independent of oxygen concentration, the microbial utilization of DOC under aerobic and anaerobic conditions differed. Under aerobic conditions, leaves were colonized by fungi, while bacteria were dominant under anoxic conditions.5. Phospholipid fatty acid profiles of the microbial communities growing on leaf extracts showed that different microbial communities developed in each oxygen concentration treatment suggesting that, irrespective of flood conditions, a microbial community will develop to utilize a significant proportion of the DOC leached from litter.
Response from Demetrio Jimenez to John Brenneman, Armory Building Construction, Camp Bullis, Texas
Creators: name: Jimenez, Demetrio
Publisher: name: Texas Historical Commission
Year: 1994
Subjects: subject: Comal (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3222/comal-county
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Armory Building
valueUri: https://core.tdar.org/browse/other-keyword/156841/armory-building
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Texas Historical Commission received and reviewed information submitted by Fort Sam Houston on the proposed construction of an Armory Building within Camp Bullis. The Commission concurs with the determination of "no adverse effect" in accordance with Section 106 guidelines.
The landscape of recombination in African Americans
Creators: name: Gillanders, Elizabeth M.
name: Ryan Diver, W.
name: Buxbaum, Sarah G.
name: Ingles, Sue A.
name: Berndt, Sonja I.
name: Boerwinkle, Eric
name: Rohland, Nadin
name: Patterson, Nick
name: Caporaso, Neil
name: Blot, William J.
name: Harris, Curtis C.
name: Song, Yunli
name: Deming, Sandra L.
name: Hinch, Anjali G.
name: Palmer, Cameron D.
name: Glessner, Joseph
name: Casey, Graham
name: Divers, Jasmin
name: Hu, Jennifer J.
name: Chen, Gary K.
name: Fornage, Myriam
name: Adrienne Cupples, L.
name: Bock, Cathryn H.
name: Aldrich, Melinda C.
name: Wang, Kai
name: Bandera, Elisa V.
name: Tandon, Arti
name: Akylbekova, Ermeg L.
name: Bernstein, Leslie
name: Ambrosone, Christine B.
name: Cai, Qiuyin
name: Amos, Christopher
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P<10−245). We identify a 17 base pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of African-enriched alleles of PRDM9.
Long distance measurement-device-independent quantum key distribution with coherent-state superpositions
Creators: name: Yin, Hua-Lei
name: Cao, Wen-Fei
name: Fu, Yao
name: Tang, Yan-Lin
name: Liu, Yang
name: Chen, Teng-Yun
name: Chen, Zeng-Bing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Measurement-device-independent quantum key distribution (MDI-QKD) with decoy-state method is believed to be securely applied to defeat various hacking attacks in practical quantum key distribution systems. Recently, the coherent-state superpositions (CSS) have emerged as an alternative to single-photon qubits for quantum information processing and metrology. Here, in this Letter, CSS are exploited as the source in MDI-QKD. We present an analytical method which gives two tight formulas to estimate the lower bound of yield and the upper bound of bit error rate. We exploit the standard statistical analysis and Chernoff bound to perform the parameter estimation. Chernoff bound can provide good bounds in the long distance MDI-QKD. Our results show that with CSS, both the security transmission distance and secure key rate are significantly improved compared with those of the weak coherent states in the finite-data case.
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
Creators: name: Kearney, M. F.
name: Kashuba, A. D.
name: Liberty, A. L.
name: Bosch, R. J.
name: Margolis, D. M.
name: Crooks, A. M.
name: Eron, J. J.
name: Strain, M. C.
name: Choudhary, S. K.
name: Richman, D. D.
name: Archin, N. M.
name: Hudgens, M. G.
name: Anderson, E. M.
name: Kuruc, J. D.
name: Coffin, J. M.
name: Hazuda, D. J.
name: Parker, D. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection [1]. Inducing the expression of latent genomes within resting CD4+ T cells is the primary strategy to clear this reservoir [2]. While histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA or vorinostat, VOR) can disrupt HIV-1 latency in vitro [3–5], the utility of this approach has never been directly proven in a translational clinical study of HIV-infected patients.Therefore we isolated the circulating resting CD4+ T cells of patients in whom viremia was fully suppressed by antiretroviral therapy (ART), and directly studied the effect of VOR in this latent reservoir. In each of eight patients studied, a single dose of VOR increased both biomarkers of cellular acetylation, and simultaneously induced an increase in HIV RNA expression in resting CD4+ cells (mean increase 4.8-fold). This is the first demonstration that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in man, provides proof-of-concept for HDAC inhibitors as a new therapeutic class, and defines a precise approach to test novel strategies to directly attack and eradicate latent HIV infection.
Camp Bullis Buildings Map Book
Creators: name: Integrated Training Area Management, U.S. Army
Publisher: name: ITAM GIS Office
Year: 2012
Subjects: subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This building maps book includes a map page reference, building number index, and accompanying map pages which show aerial photographs of Camp Bullis. Users of this map book should refer corrections, additions, and comments to the Camp Bullis ITAM GIS office.
An integrated encyclopedia of DNA elements in the human genome
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription-factor association, chromatin structure and histone modification. In this overview, the Consortium guides the readers through the project itself, the data and their integrated analyses. Eighty per cent of the human genome now has at least one biochemical function assigned to it. In addition to expanding our understanding of how gene expression is regulated on a genome-wide scale, the newly identified functional elements should help researchers to interpret the results of genome-wide associated studies because many correspond to sites associated with human disease.
An SO(10) \times SO(10)' model for common origin of neutrino masses, ordinary and dark matter-antimatter asymmetries
Creators: name: Gu, Pei-Hong
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose an SO(10) \times SO(10)' model to simultaneously realize a seesaw for Dirac neutrino masses and a leptogenesis for ordinary and dark matter-antimatter asymmetries. A (16\times \overline{16}')_H scalar crossing the SO(10) and SO(10)' sectors plays an essential role in this seesaw-leptogenesis scenario. As a result of lepton number conservation, the lightest dark nucleon as the dark matter particle should have a determined mass around 15 GeV to explain the comparable fractions of ordinary and dark matter in the present universe. The (16\times \overline{16}')_H scalar also mediates a U(1)_{em} \times U(1)'_{em} kinetic mixing after the ordinary and dark left-right symmetry breaking so that we can expect a dark nucleon scattering in direct detection experiments and/or a dark nucleon decay in indirect detection experiments. If a proper mirror symmetry is imposed, our Dirac seesaw will not require more unknown parameters than the canonical Majorana seesaw.
description: 7 pages, 2 figures
Model Law for Specific Planning Act for Floating Market Management to Promote Tourism and Community Participation
Creators: name: Usanee Peansuwan
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Model Law
Specific Planning
Floating Market
Promote Tourism
Community Participation

description: Interdisciplinary Academic and Research Journal, 3, 3, 671-684
Utility and feasibility of pharmacy directed utilization of a symptom assessment tool to reinforce adherence and assess symptom burden between visits in patients receiving oral chemotherapy
Creators: name: Allen, Stefan
name: 0000-0002-9154-4403
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Oncology
Pharmacy
Oral
Patient reported outcomes

description: Oncologists are increasingly prescribing oral antineoplastic agents (OAAs) which has benefits and challenges, which can affect patient outcomes. Practice guidelines recommend monitoring symptoms and adherence, but no specific tools or methods. Pharmacists could play an integral role in monitoring and have previously demonstrated success in related areas. This study evaluated a pilot pharmacist-delivered adherence and symptom monitoring program in patients taking OAAs for feasibility through 1) tracking patient enrollment and completed contacts and 2) pharmacist time spent on monitoring patients. Utility was evaluated through 1) patient and provider satisfaction surveys demonstrating perceived benefit and 2) comparison of clinical outcome surrogates to a retrospective cohort. This study was a prospective, interventional study with a retrospective comparator cohort at the Mays Cancer Center in San Antonio, Texas. Over six months patients receiving any of six selected OAAs (capecitabine, sorafenib, regorafenib, osimertinib, afatinib, or erlotinib) were screened to qualify for and participated in the study unless they opted out. A pharmacist was scheduled to contact them twice during each cycle or month between clinic visits for symptom or adherence monitoring over a three-month follow-up. We monitored adherence and symptoms using the Edmonton Symptom Assessment Scale (ESAS-FS). A pharmacist managed or triaged symptoms (diarrhea, mucositis, rash, nausea, and vomiting) per-protocol in collaboration with physicians. Patient contact was recorded directly in the electronic health record. Of the fifty-one patients who were screened for eligibility, 47 (92%) participated. Completed patient contact rate was high at 91% with 213 completed with 235 expected. Patients and physician satisfaction was high, but only 45% of patients indicated improved communication with physicians. Fifty-two symptom management recommendations were made with an acceptance rate of 98%. Patient reported adherence was high (98.5%). Time to first dose and duration of therapy were similar between groups, but differed by drug. The ESAS-FS was administered by pharmacy 102 times with median total score severity remaining stable over time. This study suggests that a pharmacist monitoring program for patients taking OAAs is feasible and provides utility. Further research is needed to evaluate whether this program improves safety, adherence, and outcomes in patients using OAAs.
Drawing, First Floor Window Section Building 671, Randolph Air Force Base, Texas
Creators: name: Walter, Chelsea
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Building 671
valueUri: https://core.tdar.org/browse/other-keyword/146452/building-671
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Drawings of three types of window installations that would constitute a No Effect determination for Section 106. These drawings were used in the rehabilitation of Building 671, Randolph Air Force Base, Texas. This correspondence is part of a group of letters and supporting documentation for the proposed undertaking to rehabilitate the interior of the first floor and basement at Building 671, Randolph Air Force Base, Texas. Summary documentation in the attachments include location maps, historic data, photographs, drawings, and the undertaking description and assessment.
An experimental proposal to observe non-abelian statistics of Majorana-Shockley fermions in an optical lattice
Creators: name: Deng, Dong-Ling
name: Wang, Sheng-Tao
name: Sun, Kai
name: Duan, Lu-Ming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We propose an experimental scheme to observe non-abelian statistics with cold atoms in a two dimensional optical lattice. We show that the Majorana-Schockley modes associated with line defects obey non-abelian statistics and can be created, braided, and fused, all through adiabatic shift of the local chemical potentials. The detection of the topological qubit is transformed to local measurement of the atom number on a single lattice site. We demonstrate the robustness of the braiding operation by incorporating noise and experiential imperfections in numerical simulations, and show that the requirement fits well with the current experimental technology.
description: 6 pages
MPEC 2023-D59 : 2023 BC11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 BC11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Input files for N-terminal domain of BetP de-novo modeling
Creators: name: Leone, Vanessa
name: Bradshaw, Richard T
name: Koshy, Caroline
name: Lee, Paul Suhwan
name: Forrest, Lucy R
Publisher: name: Zenodo
Year: 2021
Subjects: Secondary Transporter
Membrane Protein
BetP
De-novo modeling

description: Data needed to generate the BetP N-terminal domain de-novo models presented XX manuscript. floppytail_flag-frags-55 - Rosetta example input to generate de-novo models of the first 55 N-terminal residues of BetP frag3-nter-55 - Fragments used to generate de-novo models of the first 55 N-terminal residues of BetP floppytail_flag-nofrags-55 - Rosetta example input to generate de-novo models of the first 55 N-terminal residues of BetP without using structural fragments floppytail_flag-frags-60 - Rosetta example input to generate de-novo models of the first 60 N-terminal residues of BetP frag3-nter-60 - Fragmentes used to generate de-novo models of the first 55 N-terminal residues of BetP ini-str.pdb - Initial structure used to generate de-novo models of the N-terminal tail (models of the first 55 residues with and without structural fragments and models fo the first 60 residues) DUM.param - Centroid parameter files of dummy atoms used to mimic a lipid bilayer during the Rosetta de-novo modeling of the N-terminal tail (models of the first 55 residues with and without structural fragments and models fo the first 60 residues) DUM_fa.param - Full atom parameter files of dummy atoms used to mimic a lipid bilayer during the Rosetta de-novo modeling of the N-terminal tail (models of the first 55 residues with and without structural fragments and models fo the first 60 residues) slab_nter.cst - Restrain file used during the Rosetta de-novo modeling to discourage the N-terminal tail to sample the space occupied by the dummy atom slab (models of the first 55 residues with and without structural fragments and models fo the first 60 residues) to avoid contact-models-nter-frag-55.xvg - Count of contacts between the N-terminal tail models (first 55 residues, using structural fragments) and the rest of the trimer contact-models-nter-nofrag-55.xvg - Count of contacts between the N-terminal tail models (first 55 residues, without structural fragments) and the rest of the trimer contact-models-nter-frag-60.xvg - Count of contacts between the N-terminal tail models (first 60 residues, using structural fragments) and the rest of the trimer
OAHP Inventory, Building 2509 and Building 2510 Temporary World War II Structures, Fort Sam Houston, Texas
Creators: name: Walter, Chelsea
Publisher: name: Office of Archaeology and Historic Preservation
Year: 1978
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Building 2510
valueUri: https://core.tdar.org/browse/other-keyword/146591/building-2510
subject: Building 2509
valueUri: https://core.tdar.org/browse/other-keyword/146590/building-2509
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Administration Buildings
valueUri: https://core.tdar.org/browse/other-keyword/153383/administration-buildings
subject: Motor Repair Shop
valueUri: https://core.tdar.org/browse/other-keyword/112215/motor-repair-shop
subject: Temporary World War II Structure
valueUri: https://core.tdar.org/browse/other-keyword/159067/temporary-world-war-ii-structure
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An inventory form by the Office of Archaeology and Historic Preservation for Building 2509 and Building 2510 at Fort Sam Houston, Texas. The structures were built in 1941 as temporary World War II structures and now serve as administration buildings and a motor repair shop.
Additional file 1 of Practice characteristics influencing variation in provision of depression care in general practice in Norway; a registry-based cohort study (The Norwegian GP-DEP study)
Creators: name: Riiser, Sharline
name: Baste, Valborg
name: Haukenes, Inger
name: Smith-Sivertsen, Tone
name: Hetlevik, Øystein
name: Ruths, Sabine
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1: Supplementary Table 1. Likelihooda (crude and adjusted) of receiving talking therapy from GP (yes/no), among 285 113 patients with a new depression diagnosis in 2009-2015, by characteristics of GP practices. Supplementary Table 2. Likelihooda (crude and adjusted) of receiving antidepressant medication from GP (yes/no) among 285 113 patients with a new depression diagnosis in 2009-2015, by characteristics of GP practices. Supplementary Table 3. Likelihooda (crude and adjusted) of receiving sick leave certification from GP (yes/no), among 257 645b patients at working age with a new depression diagnosis in 2009-2015, by characteristics of GP practices.
An integrated map of genetic variation from 1,092 human genomes
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: SummaryThrough characterising the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help understand the genetic contribution to disease. We describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methodologies to integrate information across multiple algorithms and diverse data sources we provide a validated haplotype map of 38 million SNPs, 1.4 million indels and over 14 thousand larger deletions. We show that individuals from different populations carry different profiles of rare and common variants and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways and that each individual harbours hundreds of rare non-coding variants at conserved sites, such as transcription-factor-motif disrupting changes. This resource, which captures up to 98% of accessible SNPs at a frequency of 1% in populations of medical genetics focus, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations.
Copula link-based additive models for bivariate time-to-event Outcomes with general censoring scheme: Computational advances and variable ranking procedures
Creators: name: Petti, Danilo
Publisher: name: Universita degli studi di Salerno
Year: 2023
Subjects: subject: SECS S/01 STATISTICA
subject: Variable selection
subject: Bivariate survival
subject: Ultrahigh dimensionality

description: 2021 - 2022
description: La presenza di esiti bivariati basati su dati di sopravvivenza è di enorme interesse nelle scienze applicate, dove l'oggetto di studio è l'occorrenza di due eventi. Tuttavia, l'utilità pratica dei bivariate copula survival model(s) è spesso ostacolata dalla presenza di dati influenzati da vari meccanismi di censura e da dataset ad alta dimensionalità. Questa tesi presenta una soluzione innovativa per affrontare queste due sfide. Nella prima sezione, proponiamo un approccio di regressione copula generale e flessibile in grado di gestire efficacemente dati di sopravvivenza bivariati, soggetti a vari meccanismi di censura. Questo approccio offre versatilità nella modellazione dell'associazione tra i due eventi di interesse. Nella seconda sezione, introduciamo una procedura di selezione delle variabili basata sulla classe di modelli presentata nella sezione precedente. Questa procedura rappresenta una novità assoluta nel panorama dei modelli di sopravvivenza bivariati basati sulle copule. Per valutare l'efficacia delle metodologie proposte, sono stati condotti ampi studi di simulazione. Inoltre, vengono discusse illustrazioni ed esempi utilizzando dati basati sull’ Age-Related Eye Disease Study. Infine, i framework proposti sono implementati nel linguaggio di programmazione R, rendendoli accessibili a un'ampia gamma di utenti. [a cura dell'Autore]
description: Bivariate survival outcomes frequently arise in applied studies where the occurrence of two associated events of interest is observed. However, the practical utility of bivariate copula survival models is often hindered by the presence of data influenced by various censoring mechanisms and high-dimensional datasets. This thesis presents a novel solution to address these two challenges. In the first part, we propose a general and flexible copula regression approach capable of effectively handling bivariate survival data subject to various censoring mechanisms. This approach offers versatility in modelling the association between the two events of interest. In the second part, we introduce a variable selection procedure based on the class of models presented in the previous section. This procedure represents an absolute novelty in the panorama of bivariate copula survival models. To evaluate the effectiveness of the proposed methodologies, extensive simulation studies are conducted. Additionally, illustrated examples using data from the Age-Related Eye Disease Study are discussed. Lastly, the developed modelling frameworks are implemented in the R programming language, making them accessible to a wide range of users. [edited by Author]