cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Diderot, art, and the eighteenth-century ethos
Creators: name: De Rosier, Charlotte Milam
Publisher: name: University of British Columbia
Year: 2011

description: This study explores the interdependent relationship between Diderot's writings on art, the art of eighteenth-century France, and the times that produced them both. Accordingly, the study falls into three principal related sections, with each enlarging upon a specific facet of the topic. Proceeding from the premise that both Diderot and the paintings he discussed belonged within a particular cultural context of tastes, ideas, and historical facts, the first principal division, "Diderot in the Scheme of Things", begins as a brief survey of the artistic realities that prevailed in France prior to the approximate period spanned by the Salons in order to present a general view of the eclectic body of art on which he based the substance of his commentaries. The related section on "Diderot's Aesthetics" specifies a certain problem in discussing Diderot's writing on art and demonstrates that Diderot's artistic notions cannot be treated from a general aesthetic standpoint but can be understood only in terms of the individual criticisms themselves. The "Essay on Painting" presents a compendium of the themes and ideas that Diderot applied in those individual criticisms. Both the section entitled "Diderot's Aesthetics" and the one dealing with the "Essay" present transitional introductory material for the second major division, "The Salons: 1759-1781", which deals with individual criticisms of specific paintings to show Diderot's critical method at work in a varied range of representative works and to show in what way Diderot fails to understand the paintings before him in the idiom of the artist. On the basis of this conclusion, it would be easy to dismiss much of his commentary on the ground that it is quaint but inadequate; the final major division builds on this possible conclusion, however, to explore a further facet of the Salons and shows, through its focus on the Salon of 1767 that Diderot's commentaries were not merely criticisms of art but of society as well and that his attitude toward the needs and faults of society conditioned his approach to art. In its substance, this section offers the view that because of--rather than in spite of--its polarities and inconsistencies, Diderot's thoughts on contemporary art provide a faithful reflection in small of identical conflicts and aspirations in the larger context of eighteenth-century French society. Diderot's values and the values of his time emerge from his application of those values to contemporary art. With art as the matrix, the values of the man. and those of the society present themselves at the conclusion of the study as a mosaic of concepts in opposition--a mosaic where each conceptual element attains its meaning in juxtaposition, rather than in harmony, with the others.
The 1977 \Simultaneous Elections\" referendum in Tasmania"
Creators: name: Roberts-Thomson, P
Publisher: name: University Of Tasmania
Year: 2023

description: Tasmania's role in constitutional referenda, like many other aspects of her political processes has been subjected at the most to a cursory glance, but more often continual neglect. The first purpose of this study then is to attempt, albeit in a small way, to remedy this situation and describe the conduct of a referendum in Tasmania.To date no other study has concentrated specifically upon the four referenda he1d on the 21st May, 1977, nor have any studies analysed any previous referendum in Tasmania. In fact many authors dismiss out of hand Tasmania's role in a referendum and consider her propensity to deliver a negative vote as determined by fear and conservatism. The 1977 referenda have been chosen for study for a number of reasons, not least of which is that they are the most recent and much primary information is still available. In addition the memories of the principal political protagonists have not yet been blurred by the passage of time. Further Tasmania's vote was in keeping with her traditional response: to vote Yes when proposals have the overwhelming support of the whole nation and are seen as just and valid reforms to the Constitution, and on all other occasions, (except when they clearly favour the State), to vote 'No'.
Boyongan and bayugo porphyry copper-gold deposits NE Mindanao, Philippines:Geology, geochemistry, and tectonic evolution
Creators: name: Braxton, DP
Publisher: name: University Of Tasmania
Year: 2023

description: The recently-discovered Boyongan and Bayugo porphyry copper-gold deposits are part of an emerging belt of intrusion-centered gold-rich deposits in the Surigao district of NE Mindanao, Philippines. Since their formation in the Mid-Pliocene, exhumation and weathering of these deposits has lead to the development of a 600-m thick oxidation profile at Boyongan, and a modest(30-70m) oxidation profile at Bayugo. debris flows, volcanic material, and fluvio-lacustrine sediments accumulating in the actively extending Mainit graben subsequently covered the weathered deposits, preserving the supergene profiles.
title: Educating Sub-Saharan Africa
title: Assessing Mobile Application Use in a Higher Learning Engineering Programme
titleType: Subtitle
Creators: name: Eneje, Samuel
Publisher: name: Lancaster University
Year: 2022

description: In the institution where I teach, insufficient laboratory equipment for engineering education pushed students to learn via mobile phones or devices. Using mobile technologies to learn and practice is not the issue, but the more important question lies in finding out where and how they use mobile tools for learning. Through the lens of Kearney et al.’s (2012) pedagogical model, using authenticity, personalisation, and collaboration as constructs, this case study adopts a mixed-method approach to investigate the mobile learning activities of students and find out their experiences of what works and what does not work. Four questions are borne out of the over-arching research question, ‘How do students studying at a University in Nigeria perceive mobile learning in electrical and electronic engineering education?’ The first three questions are answered from qualitative, interview data analysed using thematic analysis. The fourth question investigates their collaborations on two mobile social networks using social network and message analysis. The study found how students’ mobile learning relates to the real-world practice of engineering and explained ways of adapting and overcoming the mobile tools’ limitations, and the nature of the collaborations that the students adopted, naturally, when they learn in mobile social networks. It found that mobile engineering learning can be possibly located in an offline mobile zone. It also demonstrates that investigating the effectiveness of mobile learning in the mobile social environment is possible by examining users’ interactions. The study shows how mobile learning personalisation that leads to impactful engineering learning can be achieved. The study shows how to manage most interface and technical challenges associated with mobile engineering learning and provides a new guide for educators on where and how mobile learning can be harnessed. And it revealed how engineering education can be successfully implemented through mobile tools.
Additional file 1 of Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy
Creators: name: Hao, Zhaonian
name: Li, Ruyuan
name: Wang, Yuanyuan
name: Li, Shuangying
name: Hong, Zhenya
name: Han, Zhiqiang
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Prognostic association of MDSCs and tumors. Supplementary Table 2. The association of MDSCs and response of immunotherapies.
Anderson disorder in graphene nanoribbons: A local distribution approach
Creators: name: Schubert, Gerald
name: Schleede, Jens
name: Fehske, Holger
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Disorder effects strongly influence the transport properties of graphene based nanodevices even to the point of Anderson localization. Focusing on the local density of states and its distribution function, we analyze the localization properties of actual size graphene nanoribbons. In particular we determine the time evolution and localization length of the single particle wave function in dependence on the ribbon extension and edge geometry, as well as on the disorder type and strength.
description: final version, 5 pages, 5 figures
A Constraint-directed Local Search Approach to Nurse Rostering Problems
Creators: name: He, Fang
name: Qu, Rong
Publisher: name: arXiv
Year: 2009
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: In this paper, we investigate the hybridization of constraint programming and local search techniques within a large neighbourhood search scheme for solving highly constrained nurse rostering problems. As identified by the research, a crucial part of the large neighbourhood search is the selection of the fragment (neighbourhood, i.e. the set of variables), to be relaxed and re-optimized iteratively. The success of the large neighbourhood search depends on the adequacy of this identified neighbourhood with regard to the problematic part of the solution assignment and the choice of the neighbourhood size. We investigate three strategies to choose the fragment of different sizes within the large neighbourhood search scheme. The first two strategies are tailored concerning the problem properties. The third strategy is more general, using the information of the cost from the soft constraint violations and their propagation as the indicator to choose the variables added into the fragment. The three strategies are analyzed and compared upon a benchmark nurse rostering problem. Promising results demonstrate the possibility of future work in the hybrid approach.
Some algae in lakes Hume and Mulwala 1974 Victoria
Creators: name: Viyakornvilas, K
Publisher: name: University Of Tasmania
Year: 2023

description: Lakes Hume and Mulwala have very similar plankton communities in which Melosira granulata Ralfs is dominant. The species composition and the plankton quotients show the two lakes are mesotrophic.Most of the algae seen are well-known and widespread. Micrasterias Hardyi G.S. West has only been recorded from Australia.
The role of Tasmanian general practitioners in the provision of contraception, abortion and sexual counselling services
Creators: name: Davey, M
Publisher: name: University Of Tasmania
Year: 2023

description: This survey attempts first to explore and demonstrate the attitudes and current practices of the general practitioners with regard to contraception, sterilisation, abortion and sexual behaviour, second to determine the adequacy of undergraduate and postgraduate training in family planning, and, third, to examine the general practitioners self-perceived role in providing family planning services to the community. The study of behaviour associa ed with family planning is very important in the analysis of factors involved in the continuing high levels of unwanted pregnancies, when in fact relatively safe and effective contraceptive technology is now available.
title: Weigelie :
title: Richtlinien für die Durchführung der Prüfung auf Unterscheidbarkeit, Homogenität und Beständigkeit.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Group identity.
New Varieties of Plants
Weigela

description: Zweck dieser Richtlinien („Prüfungsrichtlinien“) ist es, die in der Allgemeinen Einführung (Dokument TG/1/3) und deren verbundenen TGP-Dokumenten enthaltenen Grundsätze in detaillierte praktische Anleitung für die harmonisierte Prüfung der Unterscheidbarkeit, der Homogenität und der Beständigkeit (DUS) umzusetzen und insbesondere geeignete Merkmale für die DUS-Prüfung und die Erstellung harmonisierter Sortenbeschreibungen auszuweisen.
A Case Study Examining Japanese University Students' Digital Literacy and Perceptions of Digital Tools for Academic English learning
Creators: name: Cochrane, Robert
Publisher: name: Lancaster University
Year: 2022
Subjects: Digital literacies
Japanese (people)
Digital Natives
English language learning
Digital tools
engagement

description: Current Japanese youth are constantly connected to the Internet and using digital devices, but predominantly for social media and entertainment. According to literature on the Japanese digital native, tertiary students do not—and cannot—use technology with any reasonable fluency, but the likely reasons are rarely addressed. To fill the gap in the literature, this study, by employing a case study methodology, explores students’ experience with technology for English learning through the introduction of digital tools. First-year Japanese university students in an Academic English Program (AEP) were introduced to a variety of easily available digital tools. The instruction was administered online, and each tool was accompanied by a task directly related to classwork. Both quantitative and qualitative data were collected in the form of a pre-course Computer Literacy Survey, a post-course open-ended Reflection Activity survey, and interviews. The qualitative data was reviewed drawing on the Technology Acceptance Model (TAM) and its educational variants as an analytical framework. Educational, social, and cultural factors were also examined to help identify underlying factors that would influence students’ perceptions. The results suggest that the subjects’ lack of awareness of, and experience with, the use of technology for learning are the fundamental causes of their perceptions of initial difficulty. Based on these findings, this study proposes a possible technology integration model that enhances digital literacy for more effective language learning in the context of Japanese education.
The conductor-training for virtuosity: An investigaton into conducting technique and pedagogy
Creators: name: Quinn, C
Publisher: name: University Of Tasmania
Year: 2023

description: This paper seeks to determine the extent to which one can be prepared for the conducting profession and examines the pursuit of virtuosic conducting. The paper identifies and examines a range of skills essential to the art of conducting, the interconnection of these skills and discusses the role of practical experience in terms of skill development. The paper looks at these aspects in light of demands associated with the conducting profession and investigates aspects of current training for the profession. Different approaches and philosophies concerning conducting training are explored and associated problem areas are identified. This paper supports the belief that these problems can be addressed with suitable training and argues that if conductors were adequately trained they would be more likely to be effective from the first time they work with a professional ensemble. The paper concludes that a virtuosic level of conducting would be a more probable outcome for conductors exposed to thorough training. This paper focuses on conducting skill and technique more than artistic and interpretative issues.
Analysis of the Impact of GPX1 on Cancer and the Effect of GPX1 Stimulation and Inhibition in Human Cell Lines
Creators: name: Simpson, Ruth
Publisher: name: Lancaster University
Year: 2022
Subjects: Oxidative stress
SELENIUM SUPPLEMENTATION
Glutathione
GPX
PeroxiPlat

description: GPX1 is a selenoprotein which protects cells from damage by removing H2O2. GPX1 has a complex role in cancer development, both in promoting and protecting against cancer, and is therefore of great interest in cancer research. Bioinformatic analyses of cancer databases were used to investigate the expression of GPX1 and GPX1-interacting proteins across cancer types, as well as the effect of GPX1 expression on prognosis and chemoresistance. GPX1 production was stimulated in HaCaT, A431 and HeLa cells using sodium selenite (Na2SeO3) and measured at various timepoints using western blotting and flow cytometry. Na2SeO3-treated cells were treated with chemotherapeutic agents (cisplatin, doxorubicin, docetaxel) and H2O2, and changes to chemoresistance were measured using CyQuant and XTT assays. The interaction of a new platinum agent, PeroxiPlat, in vivo with GPX1 was investigated using flow cytometry and its inhibition of GPX1 was measured using two biochemical activity assays. GPX1 was overexpressed in the majority of cancers, and worsened prognosis for UVM, LGG, ACC, KICH and LAML patients. GPX1 was commonly overexpressed with GPX4, TP53, POLR2L, HSD17B10, and CTSD, many of which were involved in leukocyte activation. No significant correlation between GPX1 expression and chemoresistance was identified. Na2SeO3 supplementation significantly but transiently increased the level of GPX1, and increased chemoresistance, although results were inconsistent between assays. It was also found that PeroxiPlat may weakly penetrate cells and exerts a low level of GPX1 inhibition. GPX1 is clearly an important factor in cancer development and progression, and a potential target for therapy. Further research is needed to clarify the role of GPX1 in chemoresistance, although these results support existing evidence that GPX1 promotes multidrug resistance. Although PeroxiPlat does not appear to be a potent GPX1 inhibitor, its use as a fluorescent molecule warrants further investigation into the uptake and uses of PeroxiPlat.
Time-resolved charge detection with cross-correlation techniques
Creators: name: Küng, B.
name: Pfäffli, O.
name: Gustavsson, S.
name: Ihn, T.
name: Ensslin, K.
name: Reinwald, M.
name: Wegscheider, W.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present time-resolved charge sensing measurements on a GaAs double quantum dot with two proximal quantum point contact (QPC) detectors. The QPC currents are analyzed with cross-correlation techniques, which enables us to measure dot charging and discharging rates for significantly smaller signal-to-noise ratios than required for charge detection with a single QPC. This allows to reduce the current level in the detector and therefore the invasiveness of the detection process and may help to increase the available measurement bandwidth in noise-limited setups.
description: 6 pages, 4 figures
Photoionization of atoms stuffed inside a two-shell fullerene
Creators: name: Amusia, M. Ya.
name: Chernysheva, L. V.
name: Liverts, E. Z.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The photoionization of a two-shell endohedral A@CN1@CN2 is considered. Formulas are presented for cross-sections and angular anisotropy parameters, both dipole and non-dipole. The effect of the fullerenes shell upon photoelectron from atom A is taken into account substituting the action of the fullerene by two zero-thickness "bubble potential". The fullerenes shells polarization is included assuming that the radius of the outer shell R2 is much bigger than the inner R1 and both much exceeds the atomic radius r. This permits to express the effect via CN1,N2 polarizabilities, which are connected to their photoionization cross-sections. The interaction between shells CN1 and CN2 is taken into account in the Random Phase Approximation (RPA). The effect of photoelectron scattering by both "bubble potentials" is included in the lowest order and in the RPA frame. As concrete examples, two endohedrals Ar@C60@C240 and Xe@C60@C240 are considered. In the first case we consider 3p and 3s, while in the second 5p, 5s and 4d subshells. A whole variety of new peculiarities are found that deserve experimental verification.
title: Poetic to Platonic Alētheia Orality, Literacy, and the Development of Truth in Greek Poetry and Philosophy
Creators: name: Cecil, Justin B.
Publisher: name: Old Dominion University Libraries
Year: 2009

description: In recent years many scholars have dedicated much research to the development of the Orality Problem. In its most general form, the Orality Problem is grounded in the following two questions: 1) is there a difference between spoken and written language and 2) if there is a difference between these two forms of communication what exactly is this difference and how does it operate. Research into these questions has two major sources to draw upon: cross-cultural research between literate and non-literate cultures and textual analysis of written oral records from ancient Greece. According to the mounting research, many scholars now believe that the invention of literacy is responsible for ushering new modes of communication, thought, and expression into the human condition. Ifwe look back to ancient Greece, closely examine the Iliad and the Odyssey, and compare them with other recent models of oral poetry, then we can begin to see how literate notions such as abstraction, conceptual reasoning, and the formalization of language did not exist in these non-literate cultures. Based on this background I have three arguments that I am going to make in this paper. 1) Following the Orality Problem, there is a difference between oral and literate modes of communication, thought, and expression. 2) The invention of literacy in ancient Greece created a crisis in the culture that led to the development of new ways of understanding the self and the world; which in tum led to birth of philosophy in ancient Greece. 3) Through the connection between orality and poetry and literacy and philosophy we will see how the invention of literacy is connected to a shift in oral/poetic uses of truth and literate/philosophical uses of truth in ancient Greece. At the end of this project I will illustrate how the development of the concept of truth in ancient Greece is intimately connected with the development of literacy and philosophy out of a tradition of oral myth making.
Computer-paced versus self-paced arithmetic drill-and-practice
Creators: name: Dyck, Anthony Carey
Publisher: name: University of British Columbia
Year: 2011

description: An analysis of the literature showed that there is very little agreement on when and how a computer program should branch a student through a CAI program. This, together with the fact that research in the field of arithmetic has shown that drill should follow effective teaching of concepts, led the author to investigate whether students working on arithmetic drill-and-practice would do better on a COMPUTER-PACED program or a SELF-PACED program. COMPUTER-PACED was defined to be where the computer program determined when the students should be branched to more or lass difficult questions. SELF-PACED was defined to be where the students determined when they were presented more or less difficult questions by pushing one of the two marked keys on the computer terminal. The evaluation was done by comparing the achievement of the COMPUTER-PACED and the SELF-PACED groups. For the length of the study the two groups of grade six students had a daily arithmetic lesson followed by a session at a computer terminal to work on arithmetic drill-and-practice programs. The results of the post-test (adjusted by using a pre-test as a covariate) showed that there was no significant difference between the two selection mechanisms. Further analysis showed that there was no significant difference between the males and females performance and that there was no significant interaction (sex X groups) effect. The results of the study indicate that when working with arithmetic drill-and-practice, students will do as well if the computer program controls when to branch as they would if the students control when to branch to a different level of difficulty.
A discussion of Norman Bearcroft's 'Song of Exultation' as an example of The Salvation Army 'Selection'.
Creators: name: Lingard, J
Publisher: name: University Of Tasmania
Year: 2023

description: This paper will study Norman Bearcroft's work for solo comet and band, Song of Exultation. Song of Exultation is a piece that is the result of the traditions and conventions of Salvation Army musical composition. It is the intention of this paper to show that, within these conventions, this work is an example of The Salvation Army musical genre, the selection. Song of Exultation is more advanced and is on a larger scale than anything that S.P&S. usually publish bearing the title selection. However, it is the objective of this paper to show that Song of Exultation is true to the ethos of the selection, its compositional constructs and its function.
Formation of trapped surfaces for the spherically symmetric Einstein-Vlasov system
Creators: name: Andreasson, Hakan
name: Rein, Gerhard
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider the spherically symmetric, asymptotically flat, non-vacuum Einstein equations, using as matter model a collisionless gas as described by the Vlasov equation. We find explicit conditions on the initial data which guarantee the formation of a trapped surface in the evolution which in particular implies that weak cosmic censorship holds for these data. We also analyze the evolution of solutions after a trapped surface has formed and we show that the event horizon is future complete. Furthermore we find that the apparent horizon and the event horizon do not coincide. This behavior is analogous to what is found in certain Vaidya spacetimes. The analysis is carried out in Eddington-Finkelstein coordinates.
description: 27
The unconscious allocation of cognitive resources to task-relevant and task irrelevant thoughts.
Creators: name: Kuldas, Seffetullah
name: Hashim, Shahabuddin
name: Nizam Ismail, Hairul
name: Ali Samsudin, Mohd
name: Abu Bakar, Zainudin
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 520102
subject: Educational psychology
classificationCode: 520401
subject: Cognition

description: Conscious allocation of cognitive resources to task-relevant thoughts is necessary for learning. However, task-irrelevant thoughts often associated with fear of failure can enter the mind and interfere with learning. Effects like this prompt the question of whether or not learners consciously shift their cognitive resources from task-relevant to task-irrelevant thoughts. This review examines the effect of learners’ unconscious cognitive and affective processes on their resource allocation. The review concludes by calling for further research into how learners unconsciously allocate cognitive resources to task-relevant and task irrelevant thoughts.
TAUOLA, TAUOLA universal interface PHOTOS and MC-TESTER: Status Report
Creators: name: Was, Z.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The status of Monte Carlo programs for the simulation of tau-lepton production and decay in high-energy accelerator experiments is reviewed. No basic changes in the organization of the programs were necessary since the previous tau-lepton conference in 2006. Minor in size, but practical, extensions for the use of the programs in high precision mixed languages environments are being introduced: (i) For the TAUOLA Monte Carlo generator of tau-lepton decays, automated and simultaneous use of many versions of form-factors for the calculation of optional weights for fits was discussed. A pilot example of its use was presented. (ii) New tests for PHOTOS Monte Carlo for QED bremsstrahlung in W decays were shown. (iii) Prototype version of the TAUOLA universal interface based on HepMC (the C++ event record) was mentioned. Its tests with the help of MC-TESTER were discussed. Presented results illustrate the status of the projects performed in collaboration with Vladimir Cherepanov, Nadia Davidson, Piotr Golonka, Gizo Nanava, Tomasz Przedzinski Elzbieta Richter-Was and others.
description: 6 pages 3 figures, Presented at International workshop on Tau Lepton Physics, TAU08 Novosibirsk, Russia September, 2008
Observations of form in Christian Lauba's Dream in a Bar, for baritone saxophone and percussion
Creators: name: Latham, JB
Publisher: name: University Of Tasmania
Year: 2023

description: The purpose of this dissertation is to make observations of form in Christian Lauba's Dream in a Bar for baritone saxophone and percussion through an analysis of pitch, rhythmic and timbral organisation. It will be shown that Dream in a Bar is a single movement work that is essentially through-composed and does not have any large scale musical return, such as one would see in sonata form. Subsequently, this dissertation will explore other relationships by which to establish the form of the work. It will consider the large-scale functions of pitch, rhythm and timbre as organising elements. Following an outline of concepts pertaining to twentieth century musical form within the western art music tradition, the analysis will consider Lauba's use of pitch, rhythm and timbre as individual delineators of form in Dream in a Bar. The conclusion and discussion will present the findings of the analysis. This dissertation will examine the large-scale functions of pitch, rhythm and timbre in Dream in a Bar as delineators of form, rather than discussing specific small-scale events. The structure of a piece of music is perceived, not as a series of discreet independent units strung together, but as a process wherein smaller ideas function as part of a larger organisation (Cooper & Meyer,1960,2).
Characterising the role of the Amyloid Precursor Protein and Glucagon-like peptide-1 analogues in Age-Related Macular Degeneration
Creators: name: Sultan, Fatima
Publisher: name: Lancaster University
Year: 2022
Subjects: AMD, Age-related macular degeneration, APP, amyloid-beta, alpha-secretase, beta-secretase, gamma-secretase, retinal pigment epithelium, UV-A light, GLP-1 analogues, Exendin-4, Liraglutide, Lixisenatide.

description: Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterised, in some forms of the disease, by the loss of photoreceptors and the underlying retinal pigment epithelium (RPE) in the macula due to the accumulation of extracellular deposits known as “drusen”. A major component of drusen deposits is the Alzheimer’s disease (AD)-related amyloid beta (Aβ)-peptide, a 4kDa peptide derived from the larger amyloid precursor protein (APP) through sequential cleavage by enzymes known as β- and γ-secretases. Alternatively, in the ‘non-amyloidogenic’ pathway, APP can be processed by a third enzyme, α-secretase, which cleaves within the Aβ region of the protein thereby preventing the production of toxic peptides as well as producing a larger soluble fragment, sAPPα, known for its neuroprotective and neurotrophic properties. The current project aims to characterise the role played by APP and its proteolytic fragments in AMD using human retinal pigment epithelial cells (ARPE-19) and UV-A light (a known AMD risk factor) as the stressor. In addition, a group of diabetes drugs known as Glucagon Like Peptide-1 (GLP-1) analogues that have previously been purported to reduce neuronal death in AD and Parkinson’s Disease (PD) have been tested for their ability to protect ARPE-19 cells against stress-inducing reagents relative to AMD (UV-A light, hydrogen peroxide and Aβ-peptides). The results of the current study demonstrate that endogenous cell-associated full-length APP expression was depleted in ARPE-19 cells following UV-A irradiation. Furthermore, β-secretase but not α-secretase processing of the protein was reduced. Small interfering RNA-mediated depletion of endogenous APP or γ-secretase (but not α- or β-secretase) inhibition ablated the detrimental effect of UV-A on cell viability. In contrast, α-secretase and, possibly, γ-secretase but not β-secretase activity appeared to promote the longer-term proliferation of ARPE-19 cells in the absence of UV-A irradiation. Furthermore, two of the GLP-1 analogues tested, liraglutide and lixisenatide, were able to restore cell viability after UV-A exposure. Collectively, these data indicate clear links between the expression/proteolysis of APP and the proliferation and resistance of ARPE-19 cells to UV-A irradiation. Whilst these effects are clearly differential, the data warrant further investigation of the role played by APP in AMD. Furthermore, the protective effects against UV-A shown by liraglutide and lixisenatide warrant further investigation of the molecular mechanisms involved with a view to identifying new drug targets for the prevention or treatment of retinal neurodegenerative diseases such as AMD.
A new standard: Age and distance for the open cluster NGC 6791 from the eclipsing binary member V20
Creators: name: Grundahl, F.
name: Clausen, J. V.
name: Hardis, S.
name: Frandsen, S.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The detached eclipsing binary V20 in the old, metal--rich open cluster NGC 6791 is studied in order to determine highly accurate masses and radii of its components. This allows the cluster age to be established with high precision, using isochrones in the mass-radius diagram. We employ high-resolution UVES spectroscopy of V20 to determine the spectroscopic orbit and time-series V, I photometry to obtain the photometric elements. The masses and radii of the V20 components are found to be1.074+/-0.008Msun and 1.399+/-0.016Rsun (primary) and 0.827+/-0.004Msun and 0.768+/-0.006Rsun (secondary). The primary is located almost exactly at the hottest point along the cluster isochrone, and the secondary is a ~7 times fainter main--sequence star. We determine an apparent cluster distance-modulus of (m-M)_V = 13.46+/-0.10 (average of primary and secondary). The cluster age is obtained from comparisons with theoretical isochrones in the mass--radius diagram. Using the isochrones from Victoria--Regina with [Fe/H] =+0.37 we find 7.7+/-0.5Gyr, whereas the Yonsei-Yale (Y2) isochrones lead to 8.2+/-0.5Gyr, and BaSTI isochrones to 9.0+/-0.5Gyr. In a mass-radius diagram, the 7.7Gyr VRSS and 9.0Gyr BaSTI isochrones overlap nearly perfectly despite the age-difference. This model dependence, which is significantly larger than the precision determined from mass, radius, and abundance uncertainties, prevents a definitive age-determination of the cluster. By observing a suitable number of detached eclipsing binaries in several open clusters it should be possible to calibrate the age--scale and provide firm constraints which stellar models must reproduce. (abridged)
description: Accepted for publication in A&A. Tables 11 and 12 will be available in electronic format from CDS
Angular-planar CMB power spectrum
Creators: name: Pereira, Thiago S.
name: Abramo, L. Raul
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Gaussianity and statistical isotropy of the Universe are modern cosmology's minimal set of hypotheses. In this work we introduce a new statistical test to detect observational deviations from this minimal set. By defining the temperature correlation function over the whole celestial sphere, we are able to independently quantify both angular and planar dependence (modulations) of the CMB temperature power spectrum over different slices of this sphere. Given that planar dependence leads to further modulations of the usual angular power spectrum $C_l$, this test can potentially reveal richer structures in the morphology of the primordial temperature field. We have also constructed an unbiased estimator for this angular-planar power spectrum which naturally generalizes the estimator for the usual $C_l$'s. With the help of a chi-square analysis, we have used this estimator to search for observational deviations of statistical isotropy in WMAP's 5 year release data set (ILC5), where we found only slight anomalies on the angular scales $l=7$ and $l=8$. Since this angular-planar statistic is model-independent, it is ideal to employ in searches of statistical anisotropy (e.g., contaminations from the galactic plane) and to characterize non-Gaussianities.
description: Replaced to match the published version. Journal-ref: Phys.Rev. D80 063525 (2009)
Getting started with a Data Management Strategy for your Research Group
Creators: name: Dederke, Julian
name: Schmid, Fabian
Publisher: name: Zenodo
Year: 2023

description: Research environments are very vibrant; while new researchers frequently join, others leave the research group. In this light, defined rules for RDM within a research group might remain the sole resource of concerted RDM practices that enable validation and reuse of research output in and outside of your research group. Hence, having a strategy for your group’s data management in place will be pivotal to uphold good practice and consistency in RDM. Did we pique your interest? In this session, we will show how you can get started with your own data management strategy for a research group. True to the motto: Get started now. The published slide deck covers the content of this session.
The use of newcomers' experiences in the urban planning process
Creators: name: Gallins, Myra Berk
Publisher: name: University of British Columbia
Year: 2011

description: The purpose of this study was to determine whether newcomers to a large urban area, could be of special assistance to the planner. In order to discover whether newcomers could be of special use in the planning process, it was necessary to determine if newcomers' opinions of the city differed from those of longterm residents. For if they did, then the planner might be able to derive from the newcomers fresh insight into the planning problems posed by his city. Hence three hypotheses were formulated: I. Newer residents' opinions regarding the quality of their neighbourhood's services and facilities vary significantly from those of longterm residents. II. Newer residents' community participation varies significantly from that of longterm residents. III. Newer residents' views on the quality of neighbourhood services and facilities and the extent of their community participation vary significantly according to the size and location of their former residence. These hypotheses were tested by means of a questionnaire orally administered to a random sample of 108 residents of the Kitsilano area of Vancouver. On the basis of the answers obtained, each of the hypotheses was submitted to the statistical scrutiny of multiple discriminant analysis, multiple regression analysis, and percentage comparisons. Newer residents were found to have different opinions from long-term residents on the quality of their neighbourhood's services and facilities and to participate less in community activities. Within the newcomer ranks former location was an important distinguishing variable. Thus all three hypotheses were substantiated by the results of this study as well as by some earlier research findings. Hence it was concluded that residence length differences alone, were significant enough to devise some way of consulting newcomers as one aid to the urban planning process. The planner can potentially make use of the newcomers' previous experience and unencumbered perceptions to gain fresh insight into the planning problems posed by his city.
Perfect simulation of infinite range Gibbs measures and coupling with their finite range approximations
Creators: name: Galves, Antonio
name: Loecherbach, Eva
name: Orlandi, Enza
Publisher: name: arXiv
Year: 2009
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 82B20, 60K35, 60G60, 62M40

description: In this paper we address the questions of perfectly sampling a Gibbs measure with infinite range interactions and of perfectly sampling the measure together with its finite range approximations. We solve these questions by introducing a perfect simulation algorithm for the measure and for the coupled measures. The algorithm works for general Gibbsian interaction under requirements on the tails of the interaction. As a consequence we obtain an upper bound for the error we make when sampling from a finite range approximation instead of the true infinite range measure.
EDUCATION SYSTEM MANAGEMENT
Creators: name: Kambarova L.R. Tashkent State University of Economics
Publisher: name: Zenodo
Year: 2023

description: Problems of managing educational institutions in a certain degree were considered at all stages of pedagogical development science, but they concerned the most effective organizational and pedagogical conditions for the educational process and the development of practical recommendations for the organization of school affairs. Modern pedagogical science is characterized by the desire to consider education as an integral process from the standpoint of management science, to the orientation of educational institutions as a special social organization, in the adoption of general approaches and patterns, identified in the theory of organizations, in social management, management.

Key words: management, management, system, leadership, organization, leadership, education, education system.
Condition monitoring of induction motors : The detection of broken rotor bars in variable speed induction motor devices
Creators: name: Innes, AG
Publisher: name: University Of Tasmania
Year: 2023

description: The squirrel cage induction motor is the most common means of converting electrical energy to mechanical energy. As such they form a very important part of modem industrial plants. Adverse service conditions may cause faults to develop within a motor that eventually result in the motor failing. If warning of an impending failure can be obtained, the motor can be scheduled for repair or replacement before catastrophic failure occurs, thus avoiding costly excess downtime of plant. A fault which occurs in cage induction motors, is where a fracture occurs between the end ring and a rotor bar, or in an end-ring segment. These faults may be detected by examining the frequency spectrum of the stator current, while the motor is operating under loaded conditions, for the presence of characteristic frequency components. The basic theory is reasonably well known, however little work has been done on detecting faults when the motor is controlled by a variablefrequency drive, which causes extra frequency components to appear in the stator current spectrum. A variable speed drive controls the speed of an induction motor by changing the frequency of the supply voltage. Thus the problem of detecting faults becomes one of analysing a non-stationary signal. One approach to solve this problem is to synchronously sample the stator current waveform, such that the sampling process tracks any change in frequency, producing a useful frequency spectrum. A hardware system based on a phase locked loop circuit is developed in order to implement such a process. In order to determine which frequencies are produced by a pulse-width modulated (PWM) drive, a theoretical analysis of various PWM methods is carried out, with particular reference to fault frequency components. The change in frequency component amplitudes between mains operation and VSD operation and also with change in load is also examined experimentally. The uncertainty in amplitude due to the signal processing techniques employed, is also determined by experiment. The effects of changes in frequency component amplitudes on the detection of faults is discussed. A full-transient model for the induction motor is developed as an assembly of inductively coupled coils using a model that can represent the effects of individual rotor bars. The effect of a broken rotor bar on the frequencies that are introduced into the supply current can then be predicted. Finally, the possible application of time-frequency and continuous wavelet transform analysis to the problem of a non-stationary signal is examined. Various types of transform are compared to find the most suitable for tracking frequency components as they change.
title: High-dimensional propensity scores for data-driven confounder adjustment in UK electronic health records.
Creators: name: Tazare, JR
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2022

description: Electronic health record (EHR) databases are increasingly used to investigate the effect of medications. When the aim is to answer causal questions surrounding the benefits and harms of medications, a key methodological issue is confounder adjustment. Furthermore, successful mitigation of confounding effects often relies on capturing hard to measure markers of frailty, disease severity or health seeking behaviour. This can be especially hard in this context since these data are not collected for research purposes. The high-dimensional propensity score (HDPS) algorithm is a semi-automated data driven approach for confounder identification, prioritisation and adjustment tailored for use in large healthcare databases. The HDPS is increasingly applied in pharmacoepidemiological studies amid growing evidence supporting the benefit of these approaches in comparison to standard covariate adjustment methods. Developed in administrative claims databases, there has been little exploration of how best to translate the algorithm beyond this setting. In this thesis, I propose modifications for implementing HDPS principles in UK primary care EHRs that aim to better characterise features of these data. These modifications are applied to case studies where residual confounding is a key concern. In addition, I propose diagnostic tools and guidance for the reporting of HDPS approaches in general. Furthermore, the developed HDPS approaches are implemented in the Stata statistical software package. Finally, I extend the existing HDPS framework to support the incorporation of laboratory test result information. Whilst the HDPS is not a panacea, the collective findings of this thesis demonstrate the utility of HDPS approaches for overcoming intractable confounding in UK EHRs. Future work will further explore the use of test result data within the HDPS framework.
Sonet Network Design Problems
Creators: name: Pelleau, Marie
name: Van Hentenryck, Pascal
name: Truchet, Charlotte
Publisher: name: arXiv
Year: 2009
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: This paper presents a new method and a constraint-based objective function to solve two problems related to the design of optical telecommunication networks, namely the Synchronous Optical Network Ring Assignment Problem (SRAP) and the Intra-ring Synchronous Optical Network Design Problem (IDP). These network topology problems can be represented as a graph partitioning with capacity constraints as shown in previous works. We present here a new objective function and a new local search algorithm to solve these problems. Experiments conducted in Comet allow us to compare our method to previous ones and show that we obtain better results.