cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structural and functional characterisation of class VI TRIM E3 ligases
Creators: name: Stevens, Rebecca
Publisher: name: Imperial College London
Year: 2019

description: Ubiquitination is a widespread post-translational modification integral to all cellular processes. Substrate ubiquitination is catalysed by a multi-enzyme cascade consisting of E1 activating enzymes, E2 conjugating enzymes, and E3 ligase enzymes. The Tripartite Motif (TRIM) family represents the largest family of RING-type E3 ligases in humans. TRIM proteins share a conserved N-terminal domain architecture consisting of a RING domain, one or two B-box domains, and a coiled-coil. TRIMs are generally believed to bind substrates via their variable C-terminal domains and catalyse ubiquitin transfer via their conserved RING domain. TRIM-catalysed ubiquitination does not generally require additional binding partners, however, TRIM28 has been proposed to be activated and targeted to novel substrates via MAGE protein binding. Not much is known about the ubiquitination activity of TRIM28 in the absence of MAGE proteins. This TRIM has predominantly been studied for its role as a transcriptional coregulator. TRIM28 is a member of the class VI TRIM family, and along with family members TRIM24 and TRIM33 possesses a C-terminal PHD and Bromodomain. The PHD-Bromodomain acts as a histone reader, and the class VI TRIMs can be described as unusual as they all have well-described roles in transcriptional modulation which do not appear to require their E3 ligase activity. The work presented in this thesis provides the first comprehensive analysis of the E3 ligase activity of the class VI TRIM proteins. TRIM28, TRIM24, and TRIM33 are revealed to contain inactive and monomeric RING domains. Furthermore, structural analysis of the TRIM28 RING domain reveals a molecular basis for a lack of RING dimerisation and E2 binding.
title: Form and configuration, as the universal language in teaching urban morphology theory and practice
Creators: name: Lovra, Éva
name: Bereczki, Zoltán
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: The Department of Civil Engineering at the University of Debrecen fosters the Urban Systems Engineering MSc programme. The English language teaching programme has started in 2019/2020, tailored to the complex requirements of contemporary urban planning and beyond. The participating students came from different parts of the globe (Africa, Asia, South America, Europe) with mixed educational training backgrounds. Although we consider the urban form and its configuration as a universal language of urbanism and for understanding the urban environment, working with such a colourful group of young professionals has been challenging and rewarding at the same time. The current study introduces the challenges we faced during the theoretical lectures, practical fieldwork and projects of our classes: Urban Architecture, Urban Morphology and Urban Renewal Processes. As a summary, the paper highlights the main lessons learned by reviewing the courses' challenges. We discuss the teaching methods, both traditional and experimental, together with the adaptation of analyses of urban form and configurations, and the supervision tactics in the projects dedicated to Urban Architecture. Our students take part in talent fostering programmes beyond the framework of the official curricula under our mentorship. The results are inspirational and open new horizons on both sides – the next step is for some of our students to continue the academic path, namely doctoral studies under our supervision, choosing urban morphology and Space Syntax related topics.
Hackers squeeze BlackBerry for spilling juice on London riots
Creators: name: Branch, Philip
Publisher: name: Swinburne
Year: 2024

description: The hacking of BlackBerry’s official blog by the mysterious collective TeaMp0isoN raises serious questions. This black-hat hacking group, founded in 2009, has so far claimed responsibility for more than 1,400 attacks, including the extraction and release of private information belonging to former British prime minister Tony Blair. The TeaMp0isoN hackers defaced the InsideBlackBerry blog - which publishes tips and news for the BlackBerry-user community - publishing a missive stating they were outraged by the intention of Research in Motion (RIM) - a BlackBerry manufacturer - to cooperate with UK police to identify looters and rioters.
Myxoid liposarcoma in a 91-year-old patient
Creators: name: Sheffield, Brandon S.
name: Nielsen, Torsten
Publisher: name: BioMed Central
Year: 2016

description: Background: Myxoid liposarcoma is a mesenchymal malignancy most commonly presenting in young adults. This tumor is known for its characteristic chromosomal rearrangement at the DDIT3 locus. Results: We report a case of myxoid liposarcoma in a 91-year-old, the oldest known patient with this disease-entity. FISH analysis of the DDIT3 and FUS loci demonstrate the pathognomonic chromosomal alteration in the setting of predominantly round cell histology on biopsy, confirmed by RT-PCR. Conclusion: Myxoid liposarcoma affects mostly young adults but can be seen in the elderly population. Molecular and cytogenetic assays are helpful auxiliaries to histology in the setting of unusual histology and clinical presentation.
Contagion and tail risk in complex financial networks
Creators: name: Abduraimova, Kumushoy
Publisher: name: Imperial College London
Year: 2019

description: The thesis develops a unified approach to the analysis of the propagation of crises as well as economic policy throughout complex financial networks. The approach builds on new copula-based contagion measures introduced in the thesis. The developed contagion measures incorporate dependence and heavy-tailedness structure of financial and economic variables dealt with, as well as the network effect. The thesis consists of three chapters. The first chapter applies the contagion measures to study international stock market contagion during the Global Financial Crisis 2008. The findings indicate that contagion in the lower tail is stronger than in the upper one. Contagion risk has come down post-crisis, however, it still remains above its pre-crisis level. Furthermore, the chapter sheds light on the analysis of determinants of tail risk and heavy-tailedness and proposes an instrumental variable regression approach to resolve the potential endogeneity problem that arises in this kind of analysis. The second chapter extends the contagion measures to a multi-layer network setting and applies them to analyse the transmission of monetary policy in the European countries' network. This is the first study, to our knowledge, that addresses policy transmission from a network perspective. The main finding of this analysis is that the policy transmits most efficiently during severe bearish contagion and is least efficient during intense bullish contagion. This finding could be attributed to the level of attention that markets pay to policy announcements during turmoil and calm periods. The third chapter, which is a joint work with Paul Nahai-Williamson, examines solvency contagion in the interbank networks. The main insight of this chapter is that network structure matters for contagion risk and can impact the total systemic losses resulting from common shocks or individual bank defaults. This chapter further highlights the importance of capturing the network effect in the first two chapters.
Embedding non-technical skills into the accounting curricula
Creators: name: Tempone, Irene
name: Kavanagh, Marie
name: Seagal, Naomi
name: Hancock, Phil
name: Howieson, Bryan
Publisher: name: Swinburne
Year: 2024

description: This paper aims to illustrate and disseminate examples of strategies to embed non-technical skills into the accounting curricula. As part of a survey to universities to determine the relative importance of identified non-technical skills in their curricula, an invitation was given to supply examples of the embedding of these skills. The academics were then interviewed and together with unit outlines and other documentation provided, the strategy was documented with follow up interviews and other communications to verify the accuracy of the documentation. The non-technical skills most commonly embedded in the curricula were team work and oral and written communication. Non-technical skills were either embedded in one unit or across a year or program level. Several academics used ‘real world’ experiences to embed non-technical skills. Outcomes observed ranged from increased student satisfaction, increased employability, improved attendance in lectures and tutorials and improved performance in examinations. Challenges faced in implementing the strategies related to resourcing, mobility of staff and the difficulty of attributing improvements to that strategy alone. The strategies documented will contribute to the embedding of non technical skills into accounting curricula by providing academics with trialled examples. By sharing best practice in this manner communities of practice will evolve to enhance the accounting education experience for all students. This study is the most comprehensive study of its nature since the Mathews Report in 1990. While some of the strategies might have been written up individually, the collection of strategies available for dissemination to the accounting academic community has not.
title: Exploring urban street types and their impact on spatial people's aggregation in Nanjing
Creators: name: Lu, Mingyang
name: Zhang, Ye
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: In the field of urban morphology, there is a lot of understanding of how cities have evolved over time by descriptive and deductive approach. Recently, some studies introduce more rigorous quantification method and link such types to their performance though developing and testing urban types, and a few convincing conclusions achieved in European cities. However, whether this is suitable for Chinese cities with different development processes and different political and cultural issues. This study uses the similar approach to get a better understanding of relationship between street configuration and people’s aggregation in Nanjing--a typical Chinese mega-city. There are two parts in this study. The first part is to generate urban types based on integration from space syntax and cluster analysis, because it has been proven to provide reliable and efficient. The second part is to test the types developed from first part. Density of surrounding block is obtained by measuring FSI and GSI, which it captures how spatial form structures people and things. People's aggregation in the space and time dimensions use telecom data for wide coverage. This study found that the types are robust based on cluster analysis. The types were able to explain the intensity of aggregation well and the trend of type is consistent with that of FSI and GSI.
Weeding out the information: an ethnographic approach to exploring how young people make sense of the evidence on cannabis
Creators: name: Moffat, Barbara M.
name: Jenkins, Emily (Emily K.), 1981-
name: Johnson, Joy L.
Publisher: name: BioMed Central
Year: 2016

description: Background: Contradictory evidence on cannabis adds to the climate of confusion regarding the health harms related to use. This is particularly true for young people as they encounter and make sense of opposing information on cannabis. Knowledge translation (KT) is in part focused on ensuring that knowledge users have access to and understand best evidence; yet, little attention has focused on the processes youth use to weigh scientific evidence. There is growing interest in how KT efforts can involve knowledge users in shaping the delivery of youth-focused public health messages. To date, the youth voice has been largely absent from the creation of public health messages on cannabis. Methods: This ethnographic study describes a knowledge translation project that focused on engaging young people in a review of evidence on cannabis that concluded with the creation of public health messages generated by youth participants. We facilitated two groups with a total of 18 youth participants. Data included transcribed segments of weekly sessions, researcher field notes, participant research logs, and transcribed follow-up interviews. Qualitative, thematic analysis was conducted. Results: Group dynamics were influential in terms of how participants made sense of the evidence. The processes by which participants came to understand the current evidence on cannabis are described, followed by the manner in which they engaged with the literature for the purpose of creating an individual public health message to share with the group. At project end, youth created collaborative public health messages based on their understanding of the evidence illustrating their capacity to “weed out” the information. The content of these messages reflect a youth-informed harm reduction approach to cannabis use. Conclusions: This study demonstrates the feasibility of involving young people in knowledge translation initiatives that target peers. Youth participants demonstrated that they were capable of reading scientific literature and had the capacity to engage in the creation of evidence-informed public health messages on cannabis that resonate with young people. Rather than simply being the target of KT messages, they embraced the opportunity to engage in dialogue focused on cannabis.
title: Towards a sustainable urban development : the satellite city project of Kigali, Rwanda
Creators: name: Michieletto, Manlio
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: In the last decades, Africa's rapid urbanisation rate and growing metropolises have attracted the attention of urban studies pointing the need of preventing the cities' collapse (re)thinking their urban future. Kigali - the capital city of Rwanda, reacted first in 2008 with the adoption of a Masterplan recently revised and approved in 2020. The main objective of the Kigali City Masterplan is the transition to a sustainable satellite city composed by green settlements introducing at the same time a flexible zoning plan, boosting the mixed use structure in the CBD and supporting the green growth. The purpose of the paper is to examine the response given by an African City to address the issues raised by the 11th SDGs (Standard Development Goals) - titled "Sustainable Cities and Communities", through the vision of the city as a project. It is studied the use of a well-known urban development plan, the satellite city in the East African Region combined with the needs of "make cities inclusive, safe, resilient and sustainable" - as stated by United Nation in 2019, in a specific built and unbuilt context where tradition and modernity have to find the way to establish an architectural dialogue. The paper explores case studies of polycentric plans proposed over time in the Region and retrieved from the overall Kigali Master Plan two settlements - namely Kigali 2020, Kigali Vision, analysing them through a comparative method. In conclusion the research provides an analysis on how the relationship city-architecture continues to play a founding role in shaping the urban development by adopting a precise model: the satellite city.
title: 02_0864
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: Evaluation of the quality of life. Case studies of modernist housing estates in Baluty, Lodz
Creators: name: Misiak, Jakub
name: Hanzl, Malgorzata
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: While the theory of quality of life is primarily grounded in sociology and public health, urban form studies might contribute a vital ingredient. The condition and transformations of urban fabrics affect the well-being of local citizens. Spatial planning offers the potential to define norms that directly affect the cumulative nature of the development. Specifically, a noticeable shortage of research on Modernist housing estates makes decision-making challenging. Any neglect may lead to an irretrievable drop in living standards. Therefore, the ultimate goal of this study is to define the methods that can be applied to improve assessments of quality of life and liveability in Modernist structures. Carrying out a morphometric analysis enables us to characterise urban form quantitatively. We apply a GIS-based multi-criteria analysis to spatial structures and patterns. The quantitative and qualitative spatial analyses are employed to recognise endogenous and exogenous features of urban form affecting the quality of life. First, we identify the essential elements of urban form to be evaluated, i.e. street, plot or building. Furthermore, we look at their unique constituents and the hierarchies to which they contribute. The physical characteristics of the indicated elements include their dimension, shape, volume, exposure and function. We combine planning indexes (FAR, BCR, GAR) following the SpaceMatrix method. We apply the defined methods to comparatively evaluate modernist housing estates in the Bałuty district of Lodz, Poland. The need for such studies is urgent, as almost half of the city's residents live in blocks of flats. An examination of case studies enables us to reassess the methodology. From the point of view of planning practice, we recommend additional indexes to improve liveability.
Supplementary File from Translocation of mitochondrial DNA into the nuclear genome blurs phylogeographic and conservation genetic studies in seabirds
Creators: name: Lucas, Torres
name: Vincent, Bretagnolle
name: Eric, Pante
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology

description: Supplementary Information.
A Blended Active Learning Pilot: A Way to Deliver Interprofessional Pain Management Education
Creators: name: Wood, Victoria
name: Eccott, Lynda
name: Bainbridge, Lesley
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: This article presents an innovative approach to interprofessional education that places learning in the context of a specific clinical area that is relevant to pharmacy students as well as students from a number of other health professions; in this case pain management. Interprofessional pain education that teaches a team approach to pharmacy students is essential for improving pain management practices. The interprofessional education model presented, based on a pilot of a series of interprofessional pain management modules, is designed to be flexible, using a modular format that incorporates both online and face-to-face learning. The model was developed as a means of overcoming some of the challenges, such as scheduling, which make the integration of interprofessional education into curricula difficult. This technology enabled education model has been piloted and implemented with groups of pharmacy students who were placed into teams with students from other disciplines such as medicine, nursing, and social work. This article presents the educational strategy and its development; describes the interprofessional pain management modules; discusses findings from three pilot evaluations of the modules; shares lessons learned; and highlights the strengths of the approach.
title: Remote sensing the urban sprawl in South Korea : the effects of sprawl on spatial inequality
Creators: name: Mun, Jihun
name: Kim, Saehoon
name: Lee, Jae Seung
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: South Korea has experienced rapid industrialisation and urbanisation over the past half century. While unbalanced population concentrations were already problematic, urban areas in South Korea continue to expand, causing a number of adjacent cities to merge into a continuous urban region. Previous studies found that rapid urban expansion and sprawl often lead to increased spatial inequality and social disparities. There have been many attempts to measure the degree of sprawl around the world. However, studies investigating the effects of sprawl on spatial inequality in Asia remain underdeveloped. This study is an attempt to measure urban sprawl in South Korea using remote sensing techniques and to analyse the effects of sprawl on spatial inequality, which are identifiable from measures of the living environment and the quality of life of local residents based on the structural equation model (SEM). The results show that urban sprawl in South Korea has adverse effects in terms of increased economic, social, and environmental inequality. The greater the sprawl, the greater the income inequality. Job quality, air quality, and residents’ accessibility to social infrastructure also decline. Negative effects were also found in terms of the living environment and the quality of urban life in high sprawl areas.
An affective computer-mediated learning model for children with special needs
Creators: name: Valeria, Nia
Publisher: name: Swinburne
Year: 2024

description: In education, it is important to have good communication and interaction between educators and learners to produce a conducive learning environment. However, this is rather difficult for learner with disabilities such as children with Cerebral Palsy and Autism. Their learning problems arise due to their speech problems and intellectual disabilities. Having speech problem leads them to have lower ability in conveying their expressions to educators. Furthermore, some of them are slow in learning due to intellectual disabilities. The special children require more time and attention from the educators. Repetition of learning materials is one of the common solutions. They would also learn better from one-to-one learning approach. Various computer assisted learning programs have been adopted generally to supplement the special children’s learning in different areas. However, there are limitations within the existing computer assisted learning programs. This research is inspired by the concepts Collaborative Virtual Learning Environment and Affective Tutoring System. To assist the special children’s learning, this research proposed an affective computer-mediated learning model which adapts to learners’ emotions and has an educator representation i.e. a virtual tutor to deliver the learning materials and interact with special child in one-to-one learning. The virtual tutor communicates with the special child by responding to his/her facial expressions. Repetition of learning contents can be done to accommodate the learning needs of the special children. Through this research, we designed, implemented and evaluated the effectiveness of the proposed affective computer-mediated learning model in assisting the learning of the special children. We conducted a preliminary testing on the first prototype. The initial findings were used to model the final prototype. For the testing of final prototype, we carried out pre-intervention and post-intervention experiments with 20 participants from a special education school in Kuching. Pre-intervention experiments were conducted to evaluate the performance of the non-affective computer-mediated learning model. Post-intervention experiments were carried out to evaluate the performance of the affective computer-mediated learning model. The overall results showed that the proposed affective learning model is able to assist the learning of the special children.
КОСМЕТИЧЕСКИЕ РЕЗУЛЬТАТЫ РЕКОНСТРУКТИВНЫХ НЕЙРОХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВ НА ЧЕРЕПЕ
Creators: name: Копорушко Н. А.
name: Мишинов С. В.
name: Кангельдиев А. Э.
name: Ступак В. В.
Publisher: name: Политравма
Year: 2020
Subjects: косметические результаты; дефект костей черепа; черепно-мозговая травма; результат лечения; краниопластика; имплантат.

description: Согласно литературным данным, нет единой системы для оценки результата реконструктивных оперативных вмешательств у пациентов, имеющих посттрепанационные дефекты костей черепа. В ходе исследования была создана шкала, позволяющая провести оценку косметического результата после выполненной краниопластики. Также проведен сравнительный анализ между двумя типами имплантатов с целью определения влияние выбора имплантируемых изделий на косметический результат. Целью исследования явилось изучение косметических результатов реконструктивных вмешательств у больных с дефектами костей черепа с использованием индивидуальных пластин, изготовленных при помощи трехмерной печати и стандартных титановых имплантатов. Материал и методы. Клинический материал состоял из 161 больного с дефектами костей черепа, оперированного в ФГБУ «Новосибирский НИИТО им. Я.Л. Цивьяна» с 2009 по 2019 г. Анализировались следующие параметры: средний возраст, пол, сроки послеоперационного наблюдения, локализация и размер костного дефекта. Выполнен анализ полученных косметических результатов согласно данным разработанной нами шкалы. Статистическая обработка полученного материала проведена при помощи программы «Statistica v.10». Достоверность определялась статистическими методами (критерий Манна–Уитни, точный метод Фишера). Разработанная шкала валидирована методом расщепления теста и вычислением альфы Кронбаха. Результаты. Все пациенты были разделены на две группы: группа исследования (80 человек с установленными индивидуальными титановыми пластинами) и группа сравнения (81 больной – с использованием стандартных титановых имплантатов). В группе исследования все полученные результаты были отличными, у оперированных в группе сравнения отличный косметический результат получен в 76 % случаев, хороший результат достигнут у 9 %, удовлетворительный у 8 % и неудовлетворительный у 5 % человек. Статистический анализ показал, что полученные результаты зависят от вида используемого имплантата. Выводы. Использование индивидуального импланта при больших и обширных дефектах черепа позволяет получать 100% отличный косметический результат. При использовании стандартного импланта у больных с обширными дефектами черепа отличный результат в целом по группе достигается у 68 %, а в подгруппе больших дефектов у 77,8 % оперированных. Индивидуальный имплант, изготовленный методом трехмерной печати, является методом выбора при реконструктивных операциях для закрытия обширных и больших дефектов черепа.
ПРИМЕНЕНИЕ ВЕНО-ВЕНОЗНОЙ ЭКСТРАКОРПОРАЛЬНОЙ МЕМБРАННОЙ ОКСИГЕНАЦИИ БЕЗ ГЕПАРИНА У ПАЦИЕНТКИ С СОЧЕТАННОЙ ТРАВМОЙ
Creators: name: Скопец А. А.
name: Жаров А. С.
name: Потапов С. И.
name: Афонин Е. С.
name: Утегулов М. Г.
name: Козлов Д. В.
name: Чибиров С. К.
name: Муханов М. Л.
name: Шевченко А. В.
name: Барышев А. Г.
name: Порханов В. А.
Publisher: name: Политравма
Year: 2020
Subjects: сочетанная травма; ОРДС; вено-венозное ЭКМО; системная антикоагуляция.

description: Цель – обсудить возможности экстракорпоральной поддержки жизни у больных травматологического профиля. Материалы и методы. Пациентка 19 лет 26 сентября 2019 года с тяжелой сочетанной травмой на 4-е сутки после ДТП была переведена из травмоцентра 2-го уровня (центральная районная больница), в связи с прогрессирующей дыхательной недостаточностью, в травмоцентр 1-го уровня (краевая клиническая больница), где на фоне крайне тяжелого состояния, обусловленного сочетанной травмой, тяжелой дыхательной недостаточностью, нестабильной гемодинамикой и метаболическими нарушениями была выполнена экстракорпоральная респираторная поддержка с помощью вено-венозной экстракорпоральной мембранной оксигенации (ВВ-ЭКМО), которая проводилась в течение 6 дней. Результаты. В этом сообщении представлен клинический случай успешного применения ВВ-ЭКМО у пострадавшей с тяжелой сочетанной травмой, у которой на 5-е сутки травмы развился тяжелый острый респираторный дистресс-синдром. Особенностью случая было то, что ввиду опасности геморрагических осложнений, системная антикоагуляция пациентке не проводилась. На 6-й день пациентка была успешно отлучена от ВВ-ЭКМО, на 4-е сутки после отключения от ВВ-ЭКМО пациентке проведена операция: остеосинтез костей голени. На 7-е сутки после операции в удовлетворительном состоянии пациентка переведена в стационар по месту жительства. Нами описан случай успешного применения ВВ-ЭКМО без гепарина у пациентки с тяжелой сочетанной травмой, осложнившейся развитием ОРДС. Заключение. ЭКМО может служить дополнительным методом лечения взрослых пациентов с тяжелой закрытой травмой легких или острой дыхательной недостаточностью, резистентной к традиционной вентиляции. У пациентов с тяжелой травмой грудной клетки и сопутствующим геморрагическим шоком при тщательном наблюдении ВВ-ЭКМО может быть безопасным и эффективным методом спасения жизни.
Safety, immunogenicity, and tolerability of three influenza vaccines in older adults : results of a randomized, controlled comparison
Creators: name: Scheifele, David W.
name: McNeil, Shelly
name: Ward, Brian J.
name: Dionne, Marc
name: Cooper, Curtis
name: Coleman, Brenda
name: Loeb, Mark
name: Rubinstein, Ethan
name: McElhaney, Janet
name: Hatchette, Todd
name: Li, Yan
name: Montomoli, Emanuele
name: Schneeberg, Amy
name: Bettinger, Julie A.
name: Halperin, Scott A.
Publisher: name: The University of British Columbia
Year: 2016

description: To determine if newer influenza vaccines can safely improve seroprotection rates of older adults, we compared three licensed trivalent inactivated vaccines (TIVs) in a randomized, controlled trial with evaluator blinding. Participants were non-frail adults ≥ 65 y old, annually TIV-immunized. Study vaccines included intradermal (IDV), MF59-adjuvanted (ADV) and subunit (TIV) formulations of equal potency and strain composition. Blood was obtained before vaccination (V1) and 21 (V2) and 180 d (V3) afterward and tested by hemagglutination inhibition (HAI) assay. Safety diaries were completed daily by participants and specific tolerability questions were posed regarding injections and symptoms. In total, 911 participants were immunized and 887 (97.4%) completed V3. Groups had similar demographics. General symptom rates post-vaccination were similar among groups. Rates of injection site redness after IDV/ADV/TIV were 75%/13%/13% and rates of pain were 29%/38%/20%, respectively, but each vaccine was well tolerated, with symptoms causing little bother. Baseline antibody titers did not differ significantly among groups but B/Brisbane titers were too high for meaningful response assessments. At V2, seroprotection rates (HAI titer ≥ 40) were highest after ADV, the rate advantage over IDV and TIV being significant at 11.8% and 11.4% for H3N2 and 10.2% and 12.5% for H1N1, respectively. At day 180, seroprotection rates had declined ~25% and no longer differed significantly among groups. While IDV and TIV were also well tolerated, ADV induced modestly higher antibody titers in seniors to influenza A strains at 3 weeks but not 6 months post-vaccination. Immune responses to IDV and TIV were similar in this population.
title: How to rediscover the public square in the contemporary city : the experience of Lisbon
Creators: name: Narciso, José
name: Sampayo, Mafalda
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: During the 20th century and in particular, throughout the post-second world war, Lisbon's public square's design and function have changed as a consequence of the urban expansion and the cars' massification. After the Lisbon Strategic Charter 2010-2024 development, in 2014 the City Council of Lisbon presented the program of interventions in the public space "Uma praça em cada bairro" [A square in each neighborhood]. In this context, it has been proposed the qualification of more than one hundred and fifty public spaces in Lisbon. Through this paper, we aim to understand how this program contributed to rediscover the public square as an urban form and its traditional socioeconomic functions. The impact of the program and its concluded interventions were analyzed through a visual qualitative methodology. The qualitative evaluation of the previous and post-intervention spaces was enabled through the comparison of the Google Street View archives from 2009-2016 and the pictures taken during this research in 2020. By using this methodology this paper assesses the introduction of new urban elements, such as pavements, vegetation, urban furniture, lighting, and signs. This analysis shows the qualitative impact of the program "Uma praça em cada bairro" [A square in every neighborhood] on the qualification and revaluation of the public square as an urban forum in Lisbon. After the interventions the car traffic and parking was reduced about 21% of the total case studies area. Green spaces also increased, as did the areas dedicated to people.
A Review Of 5G Technology: Architecture, Security and wide Applications
Creators: name: Meer Zafarullah Noohani
name: Magsi, Kaleem Ullah
Publisher: name: figshare
Year: 2020
Subjects: subject: Computer Engineering
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The eventual goal of the forthcoming 5G wireless networking is to have relatively fast data speeds, incredibly low latency, substantial rises in base station’s efficiency and major changes in expected Quality of Service (QoS) for customers relative to the existing 4G LTE networks. In order to deal with state-of-the art technologies and connectivity in the form of smart cell phones, internet of things (IoT) devices, autonomous vehicles, virtual reality devices and smart homes connectivity, the broadband data use has risen at a fast rate. Further, to meet the latest applications, the bandwidth of the system needs to be increased widely. This development will be accomplished by using a modern spectrum with higher data levels. In particular, the fifth generation (5G) mobile network seeks to resolve the shortcomings of previous telecommunication technologies and to be a possible primary enabler for future IoT applications. This paper briefly discusses the architecture of 5G, following by the security associated with the 5G network, 5G as an energy efficient network, various types of efficient antennas developed for 5G and state-of-the-art specifications for IoT applications along with their related communication technologies. We have also outlined the broader usage of 5G and its future impacts on our lives. Furthermore, at the end of each subtopic, the necessary recommendations are given for the future work.
title: Transforming slums through urban intensification
Creators: name: Omer, Khalafalla
name: Moustaka, Athina
name: Watts, Gregory
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: Unplanned rapid urbanization is leading to the mass formation of informal settlements in many developing cities around the world. It is estimated that globally approximately 30% of urban residents inhabit such informal settlements. These settlements are characterized by poor physical urban structures, insecure land tenure, overcrowding, and poor Infrastructure. Current literature on slum upgrading mechanisms focus on economic and community trends driven by public health debates. These tend to place emphasis on the improvement of infrastructure by examining the role of microfinance and other community-based approaches to qualify, address and map the existing slum challenges. Other arguments in contemporary literature focus on the role the private sector can play in addressing the challenges and opportunities faced in the upgrading of slums. Despite the evolution of arguments in the literature, conflicting approaches have led to little progress being made to address the problems caused by the increase in slum settlements. The problem therefore exists as to how such informal settlements can be addressed and upgraded to enhance the liveability standards of public space and building units. Through a systematic and in-depth literature review, this paper aims to structure and analyse contemporary arguments around the implication of informal slum settlements, the impact of the property market on the redevelopment process, and the planning for sustainable urban form. The results reveal how land readjustment approach, financial systems, and development approach can impact both the public realm and physical structures whilst stimulating viable redevelopment processes for the slum settlements. This paper then sets out a future research agenda by identifying areas of literature that illustrate the greatest potential for tackling the problems presented by the growth in such informal slum settlements.
title: The effects of urban morphology on enriching thermal experience : microclimates of courtyard spaces in Cambridge
Creators: name: Peng, Zhikai
name: Bardhan, Ronita
name: Steemers, Koen
Publisher: name: University of Strathclyde Publishing
Year: 2022

description: The microclimate shaped by urban form is one of the critical determinants for the success of public spaces. To date, hundreds of studies have revealed the potential of mitigating heat and cold stresses by spatial-enclosure strategies to reduce thermal discomfort. However, most of them have placed more emphasis on taming the thermal extremes, rather than on enriching the microclimatic context to benefit the thermal experience. A rich thermal context with varied, mild thermal stress would enhance psychological adaptation, affording flexibility and meeting different thermal preferences of sun, shade, wind and stillness. Therefore, we aim to investigate the morphological effects on these thermal qualities, and to compare not only the cooling performance of geometries but also the microclimatic diversity and hourly fluctuation in thermal stress. More than a hundred fully enclosed courtyards (n=107) were selected across 31 colleges and 10 teaching sites at the University of Cambridge. We have completed 20-hour microclimate simulations at 33 domains with boundary conditions near the summer solstice and the ENVI-met simulation results were fed back into the heatmap through Urbano, Dragonfly and Ladybug plugs-in in Grasshopper. We found much stronger morphological effects on the variations of sun and wind than on air temperature and humidity. The inferential statistical analysis has also shown that the compacity of building shades and the vegetation configurations play crucial roles in taming thermal extremes and enriching the urban thermal contexts at the human scale.
Towards an ecological civilization: a Gramscian strategy for a new political subject
Creators: name: Ahearne, Gerard
Publisher: name: Swinburne
Year: 2024

description: While much work has been done theorising the concept of an ecological civilization, the actual transition to an ecological civilization is another matter. One possible strategy for transforming our world from a death-rattle industrial civilization to a life affirming ecological civilization may be found in the later work of Antonio Gramsci. It is argued that as Gramsci became increasingly disillusioned with Soviet communism, and diagnosed its failure as due to the way opposition movements tend to mirror the ways of thinking, practices and organization of those they are opposing. To avoid this tendency, Gramsci called not for a 'counter-hegemony', but an alternative hegemony based on a different conception of the world. The notion of 'ecological civilization' could provide this, offering the foundation for the moral leadership required in a war of position to genuinely overcome and replace existing socio-economic forms.
КЛИНИЧЕСКИЙ СЛУЧАЙ МНОГОЭТАПНОГО ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ПАЦИЕНТКИ С ВЕРТЕБРАЛЬНОЙ ИМПЛАНТ-АССОЦИИРОВАННОЙ ИНФЕКЦИЕЙ
Creators: name: Кочнев Е. Я.
name: Мухтяев С. В.
name: Мещерягина И. А.
name: Гребенюк Л. А.
Publisher: name: Политравма
Year: 2020
Subjects: политравма; имплант-ассоциированная инфекция; транспедикулярная фиксация; межтеловой спондилодез

description: Актуальность работы обусловлена высоким риском возникновения инфицирования в области оперативного вмешательства на позвоночнике при политравме. Цель – показать клинический пример результата многоэтапного хирургического лечения пациентки с политравмой, осложненной вертебральной имплант-ассоциированной инфекцией и неврологическим дефицитом. Материал и методы. Пациентка 45 лет оперирована по месту жительства после кататравмы по поводу перелома L2 позвонка из тораколюмботомического доступа, одномоментно пациентке выполнен остеосинтез костей правой голени, левой предплюсны. В раннем послеоперационном периоде произошло нагноение в области имплантированной металлоконструкции на позвоночнике. Больной проведено комплексное многоэтапное оперативное вмешательство в связи с развитием хронического остеомиелита поясничных позвонков свищевой формы, интеграция наружных и внутренних стабилизирующих транспедикулярных систем, с последующим корпородезом. Результаты. Пациентка осмотрена через 2 года после последнего этапа оперативного лечения. Отмечено отсутствие признаков гнойного процесса, болевого синдрома, уменьшен неврологический дефицит. Ходит без дополнительных средств опоры. Заключение. Выбранная тактика комплексного многоэтапного лечения у данной пациентки, основанная на клинической картине заболевания, соблюдение последовательности и принципов лечения гнойных процессов позволили решить все имевшиеся в данном случае задачи: добиться стойкой ремиссии гнойного процесса, улучшить качество жизни пациентки.
“Nonmedical” prescription opioid use in North America: a call for priority action
Creators: name: Voon, Pauline
name: Kerr, Thomas
Publisher: name: BioMed Central
Year: 2015

description: Nearly four years after the United States Congress heralded a “decade of pain control and research”, chronic pain remains a mounting public health concern worldwide. The escalating prevalence of chronic pain in recent years has been paralleled by a rise in prescription opioid availability, misuse, and associated human and social costs. However, national monitoring surveys in the U.S. and Canada currently fail to differentiate between prescription opioid misuse for the purposes of euphoria versus pain or withdrawal management. Furthermore, there is a lack of evidence-based guidelines for pain management among high-risk individuals, and a glaring lack of education for practitioners in the areas of pain and addiction medicine. Herein we propose multiple avenues for intervention and research in order to mitigate the individual, social and structural problems related to undertreated pain and prescription opioid misuse.
Community analysis of coral mucus-associated bacteria and impact of temperature and CO
Creators: name: Ho, Juliana Sing Fang
Publisher: name: Swinburne
Year: 2024

description: The coral holobiont is a complex assemblage of the coral animal and microbial organism. Coral mucus harbours distinct microbial communities and bacteria living in the coral mucus play a major role in the survival of corals. While several studies have assessed their importance in protecting their coral hosts from disease, very little is known about the response of these bacteria to climate change. One of the major consequences of climate changes are enhanced ocean temperatures which lead to coral bleaching. Another major cause of coral bleaching is the increased amount of anthropogenic carbon dioxide (CO2) which leads to a phenomenon called ocean acidification. In both cases, very little its known about how bacteria living in the coral mucus react to the changing conditions. In a laboratory-based experiment, we assessed the impact of temperature and carbon dioxide elevation on mucus-associated bacteria in Trachyphyllia geoffroyi, Euphyllia ancora and Corallimorphs sp.. Fragments of the selected corals were placed into tanks and exposed to enhanced concentrations of CO2 and temperature in a series of experiments. Coral mucus samples were collected on a weekly basis and CO2 concentrations monitored using a Fourier-Transform Infrared (FTIR) trace gas analyzer. Potential changes in the coral mucus-associated bacteria communities were monitored by (a) culture based and (b) molecular approaches. Mucus samples were cultured weekly and bacterial isolates identified using Sanger sequencing. Furthermore, fingerprinting methods such as Denaturing Gel Gradient Electrophoresis (DGGE) and Ribosomal Intergenic Spacer analysis (RISA) were applied to monitor changes in the microbial communities. Enzymatic properties (amylase, caseinase, gelatinase and phospholipase) of the coral mucus-associated bacteria were also assessed to identify potential pathogenic bacteria. Significant shifts were detected in all three corals. For Trachyphyllia geoffroyi, Euphyllia ancora and Corallimorphs sp., When the temperature and carbon dioxide were maintained around 25°C to 28°C and 500 ppm, Vibrio sp., Bacillus sp. and Pseudomonas sp. were found but as temperature increases up to 29°C, Bacillus sp. started to dominate. However, when both temperature and carbon dioxide were rised up to stressful conditions for the corals, Vibrio sp. dominated the corals mucus layers. Lastly, the isolation of bacteriophage that has the ability to cause a plaque in the Bacteriophage Plaque Assay when tested against selected potential pathogens was also identified. The species identified are phylogenetically 96% similar to Enterobacteriophage reference strain, which are potential bacteriophages for the inhibition of marine pathogens. There were shifts in Trachyphyllia geoffroyi, Euphyllia ancora and Corallimorphs sp. mucus-associated bacteria community when temperature and carbon dioxide content of the corals surrounding changes.
Geschichtsverein der Diözese Rottenburg-Stuttgart (Hg.), Rottenburger Jahrbuch für Kirchengeschichte, Band 35: Mann – Frau – Partnerschaft. Genderdebatten des Christentums
Creators: name: Gause, Ute
Publisher: name: theologie.geschichte
Year: 2019

description: theologie.geschichte, Bd. 14 (2019)