cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Graphdiyne-metal contacts and graphdiyne transistors
Creators: name: Pan, Yuanyuan
name: Wang, Yangyang
name: Wang, Lu
name: Zhong, Hongxia
name: Quhe, Ruge
name: Ni, Zeyuan
name: Ye, Meng
name: Mei, Wai-Ning
name: Shi, Junjie
name: Guo, Wanlin
name: Yang, Jinbo
name: Lu, Jing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Graphdiyne is prepared on metal surface, and making devices out of it also inevitably involves contact with metals. Using density functional theory with dispersion correction, we systematically studied for the first time the interfacial properties of graphdiyne contacting with a series of metals (Al, Ag, Cu, Au, Ir, Pt, Ni, and Pd). Graphdiyne is in an n-type Ohmic or quasi-Ohmic contact with Al, Ag, and Cu, while it is in a Schottky contact with Au (at source/drain interface), Pd, Pt, Ni, and Ir (at source/drain-channel interface), with high Schottky barrier heights of 0.39, 0.21 (n-type), 0.30, 0.41, and 0.45 (p-type) eV, respectively. A graphdiyne field effect transistor (FET) with Al electrodes is simulated by using quantum transport calculations. This device exhibits an on-off ratio up to 104 and a very large on-state current of 1.3 * 104 mA/mm in a 10 nm channel length. Thus, a new prospect is opened up for graphdiyne in high performance nanoscale devices.
description: 27 pages, 9 figures
Expanding Access to Medications for Opioid Use Disorder Treatment Through Incentivized Continuing Education
Creators: name: Salisbury-Afshar, Elizabeth
name: Smithenry, Dennis
name: Boley, Randy A
name: Hill, Kristin
name: Karnik, Niranjan S
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: INTRODUCTION: Buprenorphine treatment for opioid use disorder (OUD) has positive outcomes including reducing opioid-related morbidity and mortality. In March 2018, 58 of 102 counties in Illinois lacked access to medication for OUD. METHODS: Rush University created a fellowship training program with financial incentives to help expand buprenorphine treatment in Illinois. Fellows first completed an online waiver course, then attended an in-person intensive training weekend, and finally participated in a 9-month webinar series. Demographic and prescribing data were collected from fellows, as well as a comparison group of providers outside the fellowship who only completed a waiver training. RESULTS: At the fellowship's end, 31 of 37 fellows (84%) reported they were actively prescribing buprenorphine. Of the 23 fellows who were not prescribing at the fellowship's beginning, 17 (74%) initiated prescribing by the end. Among the 16 nonfellowship subjects who only completed a waiver training, just two (13%) reported they were prescribing buprenorphine at the study period's end. DISCUSSION: Our study indicates that providers need more training beyond the waiver to initiate buprenorphine prescribing. When resources are available to address a health crisis such as OUD, this model offers an innovative mechanism for delivering continuing medical education that produces outcomes quickly.
Natural Language Processing for Drug Discovery Knowledge Graphs: promises and pitfalls
Creators: name: Jeynes, J. Charles G.
name: James, Tim
name: Corney, Matthew
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Building and analysing knowledge graphs (KGs) to aid drug discovery is a topical area of research. A salient feature of KGs is their ability to combine many heterogeneous data sources in a format that facilitates discovering connections. The utility of KGs has been exemplified in areas such as drug repurposing, with insights made through manual exploration and modelling of the data. In this article, we discuss promises and pitfalls of using natural language processing (NLP) to mine unstructured text typically from scientific literature as a data source for KGs. This draws on our experience of initially parsing structured data sources such as ChEMBL as the basis for data within a KG, and then enriching or expanding upon them using NLP. The fundamental promise of NLP for KGs is the automated extraction of data from millions of documents a task practically impossible to do via human curation alone. However, there are many potential pitfalls in NLP-KG pipelines such as incorrect named entity recognition and ontology linking all of which could ultimately lead to erroneous inferences and conclusions.
description: 17 pages, 7 figures
New Models of Tetrahymena Telomerase RNA from Experimentally Derived Constraints and Modeling
Creators: name: Legassie, Jason D.
name: Cole, Daud I.
name: Dokholyan, Nikolay V.
name: Bonifacio, Laura N.
name: Ding, Feng
name: Sekaran, Vijay G.
name: Jarstfer, Michael B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Telomerase RNA, TER, provides the template for replicating the G-rich strand of telomeric DNA, provides an anchor site for telomerase-associated proteins, and participates in catalysis through several incompletely characterized mechanisms. A major impediment towards understanding its non-templating roles is the absence of high content structural information for TER within the telomerase complex. Here, we used selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) to examine the structure of Tetrahymena TER free in solution and bound to tTERT in the minimal telomerase RNP. We discovered a striking difference in the two conformations and established direct evidence for base pair triples in the tTER pseudoknot. We then used SHAPE data, previously published FRET data, and biochemical inference to model the structure of tTER using discrete molecular dynamics simulations. The resulting tTER structure was docked with a homology model of tTERT to characterize the conformational changes of tTER that attend binding to tTERT. Free in solution, tTER appears to contain four pairing regions: stems I, II, and IV, which are present in the commonly accepted structure, and stem III, a large paired region that encompasses the template and pseudoknot domains. Our interpretation of the data and subsequent modeling affords a molecular model for telomerase assemblage in which a large stem III of tTER unwinds to allow proper association of the template with the tTERT active site and formation of the pseudoknot. Additionally, analysis of our SHAPE data and previous enzymatic footpinting allows us to propose a model for stem-loop IV function in which tTERT is activated by binding stem IV in the major grove of the helix-capping loop.
Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing
Creators: name: Galloway, Ashley L.
name: Rolland, Jason P.
name: Murphy, Andrew
name: Wang, Jin
name: Dunn, Stuart S.
name: Napier, Mary E.
name: Pohlhaus, Patrick D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A critical need still remains for effective delivery of RNA interference (RNAi) therapeutics to target tissues and cells. Self-assembled lipid- and polymer-based systems have been most extensively explored for transfection with small interfering RNA (siRNA) in liver and cancer therapies. Safety and compatibility of materials implemented in delivery systems must be ensured to maximize therapeutic indices. Hydrogel nanoparticles of defined dimensions and compositions, prepared via a particle molding process that is a unique off-shoot of soft lithography known as PRINT (Particle Replication in Non-wetting Templates), were explored in these studies as delivery vectors. Initially, siRNA was encapsulated in particles through electrostatic association and physical entrapment. Dose-dependent gene silencing was elicited by PEGylated hydrogels at low siRNA doses without cytotoxicity. To prevent disassociation of cargo from particles after systemic administration or during post-fabrication processing for surface functionalization, a polymerizable siRNA pro-drug conjugate with a degradable, disulfide linkage was prepared. Triggered release of siRNA from the prodrug hydrogels was observed under a reducing environment while cargo retention and integrity were maintained under physiological conditions. Gene silencing efficiency and cytocompatibility were optimized by screening the amine content of the particles. When appropriate control siRNA cargos were loaded into hydrogels, gene knockdown was only encountered for hydrogels containing releasable, target-specific siRNAs, accompanied by minimal cell death. Further investigation into shape, size, and surface decoration of siRNA-conjugated hydrogels should enable efficacious targeted in vivo RNAi therapies.
Multimodal Representations for Teacher-Guided Compositional Visual Reasoning
Creators: name: Aissa, Wafa
name: Ferecatu, Marin
name: Crucianu, Michel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Neural Module Networks (NMN) are a compelling method for visual question answering, enabling the translation of a question into a program consisting of a series of reasoning sub-tasks that are sequentially executed on the image to produce an answer. NMNs provide enhanced explainability compared to integrated models, allowing for a better understanding of the underlying reasoning process. To improve the effectiveness of NMNs we propose to exploit features obtained by a large-scale cross-modal encoder. Also, the current training approach of NMNs relies on the propagation of module outputs to subsequent modules, leading to the accumulation of prediction errors and the generation of false answers. To mitigate this, we introduce an NMN learning strategy involving scheduled teacher guidance. Initially, the model is fully guided by the ground-truth intermediate outputs, but gradually transitions to an autonomous behavior as training progresses. This reduces error accumulation, thus improving training efficiency and final performance.We demonstrate that by incorporating cross-modal features and employing more effective training techniques for NMN, we achieve a favorable balance between performance and transparency in the reasoning process.
Rendering Protein-Based Particles Transiently Insoluble for Therapeutic Applications
Creators: name: Xu, Jing
name: Pohlhaus, Patrick
name: Hubby, Bolyn
name: Smith, Jonathan
name: Napier, Mary E.
name: Maynor, Benjamin W.
name: Pandya, Ashish A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Herein we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.
Bertutur Radikalisme terhadap Pemberdayaan Manusia
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences
subject: 130201 Creative Arts, Media and Communication Curriculum and Pedagogy
subject: 130202 Curriculum and Pedagogy Theory and Development
subject: 130299 Curriculum and Pedagogy not elsewhere classified
subject: 220302 Decision Theory
subject: FOS: Philosophy, ethics and religion
subject: 130303 Education Assessment and Evaluation
subject: 130203 Economics, Business and Management Curriculum and Pedagogy
subject: 130305 Educational Counselling
subject: 130304 Educational Administration, Management and Leadership
subject: 139999 Education not elsewhere classified

description: https://doi.org/10.34148/komatika.v1i2.428
AbstractProgram pengabdian masyarakat merupakan titik tumpuh bagi peningkatan kapital manusia untuk
melanjutkan taraf hidup yang teratur. Program ini merupakan bagian dari pengembangan ilmu dan dapat
ditinjau dalam perspektif sosial maupun kemanusiaan, yang mendalam. Pada kenyataannya, program ini
tidak selalu berujung signifikan, dikarenakan berbagai faktor yang sangat mungkin memengaruhi, termasuk
kebijakan pemerintah. Dengan demikian, program dan kerangka evaluasi pemberdayaan masyarakat
sangat perlu untuk dikonstruksikan, lewat salah satu pendekatan, yaitu kajian ilmiah. Evaluasi merupakan
alat untuk mengukur kapasitas aktor yang melaksanakan satu program atau kegiatan, juga merupakan
laboratorium ilmiah dalam melihat kedalaman serta sinkronisasi materi serta media yang dipakai selama
program berlangsung. Lebih mendalam yaitu, evaluasi sangat memengaruhi dampak dari luaran program,
apakah berjalan berkesinambungan, mati suri, maupun, terhambat. Lebih jauh lagi, evaluasi dipakai untuk
mengontrol kebijakan pemerintah agar dapat bersinergi dengan berbagai program pembangunan
masyarakat serta lingkungan, untuk mencapai perkembangan bangsa yang maju di segala lini. Maka itu,
artikel ini bernarasi tentang pengembangan program evaluasi terhadap berbagai jenis program
pemberdayaan masyarakat, yang dapat diadaptasi oleh para pelaku program ini. Kesimpulan yang saya
lihat yaitu program evaluasi memberikan ruang bagi seluruh pelaku program dan sekaligus pemerintah
dalam usaha untuk mengembangkan segala potensi bangsa yang dapat dipakai sebagai investasi jangka
panjang.Copyright (c) 2021 thobias sarbunanThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.How to CiteSarbunan, T. (2021). Bertutur Radikalisme terhadap Pemberdayaan Manusia. Komatika: Jurnal Pengabdian Kepada Masyarakat, 1(2), 42-48. https://doi.org/10.34148/komatika.v1i2.428Vol 1 No 2 (2021): November 2021
Clouds : empirically determining substellar cloud compositions in the era of JWST
Creators: name: Luna, Jessica L.
name: 0000-0003-2152-9248
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Brown dwarfs
L dwarfs
Stellar atmospheres
Extrasolar gaseous giant planets
Exoplanet atmospheres

description: For decades, the long standing question of the cloud condensation sequence for substellar atmospheres, has been unknown. Theory predicts that an objects temperature controls which clouds form in a substellar atmosphere. However the specific species, condensation sequence, particle sizes, locations and crystalline structures are still debated. Particularly, the Ackerman & Marley (2001) cloud model presents a mismatch between theoretical model spectra and data from the SPITZER space telescope for both photometric and spectroscopic observations. Here we create a new cloudy model grid for brown dwarf and exoplanet atmospheres that includes the effects of particle size, composition and crystalline structure. We show that the optical constants of particular minerals when varying particle size, location and crystalline structure can change the spectral features across ∼1-20μm. We then compare our new cloudy models to SPITZER/IRAC photometric data and SPITZER/IRS spectroscopic data that better match the space observations. Using the informed data analysis of 5 brown dwarfs known for tentative evidence of the silicate feature across 8-10μm, we then create model thermal emission spectra based our new cloudy models. These models can be used to compare to newly released JWST spectra for the Cycle 1 data release. We predict that by monitoring both variable and non- variable gas-giant atmospheres with the newly launched MIRI on JWST, we can determine the cloud condensation sequence and establish weather as the cause for brown dwarf variability, removing previous ambiguity.
Higgs Model Coupled to Dark Photons
Creators: name: Cárcamo, Dante
name: Gamboa, Jorge
name: Pino, Miguel
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A dark sector containing a Higgs field and a dark photon coupled to visible photons via a small kinetic mixing is considered. The mass of the dark gauge boson becomes rescaled by the parameter involved in the kinetic mixing. We also calculate the total annihilation cross section for scalar Higgs interacting with an external field and show that exhibits Sommerfeld enhancement. The model can be extended to a $SU(3)\times SU(2)\times U(1)$ dark sector. The mass of the dark $Z$ boson increases due to the kinetic mixing.
description: 6 pages, 1 figure
Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction
Creators: name: Shock, David D.
name: Batra, Vinod K.
name: Beard, William A.
name: Wilson, Samuel H.
name: Lin, Ping
name: Pedersen, Lars C.
name: Pedersen, Lee G.
name: Perera, Lalith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: DNA polymerase β (pol β) is a bifunctional enzyme widely studied for its roles in base excision DNA repair where one key function is gap-filling DNA synthesis. In spite of significant progress in recent years, the atomic level mechanism of the DNA synthesis reaction has remained poorly understood. Based on crystal structures of pol β in complex with its substrates and theoretical considerations of amino acids and metals in the active site, we have proposed that a nearby carboxylate group of Asp256 enables the reaction by accepting a proton from the primer O3′ group, thus activating O3′ as the nucleophile in the reaction path. Here, we tested this proposal by altering the side chain of Asp256 to Glu and then exploring the impact of this conservative change on the reaction. The D256E enzyme is more than 1,000-fold less active than the wild-type enzyme, and the crystal structures are subtly different in the active sites of the D256E and wild-type enzymes. Theoretical analysis of DNA synthesis by the D256E enzyme shows that the O3′ proton still transfers to the nearby carboxylate of residue 256. However, the electrostatic stabilization and location of the O3′ proton transfer during the reaction path are dramatically altered compared with wild-type. Surprisingly, this is due to repositioning of the Arg254 side chain in the Glu256 enzyme active site, such that Arg254 is not in position to stabilize the proton transfer from O3′. The theoretical results with the wild-type enzyme indicate early charge reorganization associated with the O3′ proton transfer, and this does not occur in the D256E enzyme. The charge reorganization is mediated by the catalytic magnesium ion in the active site.
Metal–Organic Frameworks as A Tunable Platform for Designing Functional Molecular Materials
Creators: name: Wang, Cheng
name: Liu, Demin
name: Lin, Wenbin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Metal-organic frameworks (MOFs), also known as coordination polymers, represent an interesting class of crystalline molecular materials that are synthesized by combining metal-connecting points and bridging ligands. The modular nature of and mild conditions for MOF synthesis have permitted the rational structural design of numerous MOFs and the incorporation of various functionalities via constituent building blocks. The resulting designer MOFs have shown promise for applications in a number of areas, including gas storage/separation, nonlinear optics/ferroelectricity, catalysis, energy conversion/storage, chemical sensing, biomedical imaging, and drug delivery. The structure-property relationships of MOFs can also be readily established by taking advantage of the knowledge of their detailed atomic structures, which enables fine-tuning of their functionalities for desired applications. Through the combination of molecular synthesis and crystal engineering MOFs thus present an unprecedented opportunity for the rational and precise design of functional materials.
Detecting Intentional AIS Shutdown in Open Sea Maritime Surveillance Using Self-Supervised Deep Learning
Creators: name: Bernabé, Pierre
name: Gotlieb, Arnaud
name: Legeard, Bruno
name: Marijan, Dusica
name: Sem-Jacobsen, Frank Olaf
name: Spieker, Helge
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: In maritime traffic surveillance, detecting illegal activities, such as illegal fishing or transshipment of illicit products is a crucial task of the coastal administration. In the open sea, one has to rely on Automatic Identification System (AIS) message transmitted by on-board transponders, which are captured by surveillance satellites. However, insincere vessels often intentionally shut down their AIS transponders to hide illegal activities. In the open sea, it is very challenging to differentiate intentional AIS shutdowns from missing reception due to protocol limitations, bad weather conditions or restricting satellite positions. This paper presents a novel approach for the detection of abnormal AIS missing reception based on self-supervised deep learning techniques and transformer models. Using historical data, the trained model predicts if a message should be received in the upcoming minute or not. Afterwards, the model reports on detected anomalies by comparing the prediction with what actually happens. Our method can process AIS messages in real-time, in particular, more than 500 Millions AIS messages per month, corresponding to the trajectories of more than 60 000 ships. The method is evaluated on 1-year of real-world data coming from four Norwegian surveillance satellites. Using related research results, we validated our method by rediscovering already detected intentional AIS shutdowns.
description: IEEE Transactions on Intelligent Transportation Systems
The $Z_2$ Classification of Dimensional Reduced Hopf Insulators
Creators: name: Wang, Chang-Yan
name: He, Yan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The Hopf insulators are characterized by a topological invariant called Hopf index which classifies maps from three-sphere to two-sphere, instead of a Chern number or a Chern parity. In contrast to topological insulator, the Hopf insulator is not protected by any kind of symmetry. By dimensional reduction, we argue that there exists a new type of $\mathbb{Z}_2$ index for 2D Hamiltonian with vanishing Chern number. Specific model Hamiltonian with this nontrivial $\mathbb{Z}_2$ index is constructed. We also numerically calculate the topological protected edge modes of this dimensional reduced Hopf insulator and show that they are consistent with the $\mathbb{Z}_2$ classification.
description: 6 pages, 3 figures
Characterizing Slow Chemical Exchange in Nucleic Acids by Carbon CEST and Low Spin-Lock Field R 1ρ NMR Spectroscopy
Creators: name: Zhang, Qi
name: Zhao, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Quantitative characterization of dynamic exchange between various conformational states provides essential insights into the molecular basis of many regulatory RNA functions. Here, we present an application of nucleic-acid-optimized carbon chemical exchange saturation transfer (CEST) and low spin-lock field R1ρ relaxation dispersion (RD) NMR experiments in characterizing slow chemical exchange in nucleic acids that is otherwise difficult if not impossible to be quantified by the ZZ-exchange NMR experiment. We demonstrated the application on a 47-nucleotide fluoride riboswitch in the ligand-free state, for which CEST and R1ρ RD profiles of base and sugar carbons revealed slow exchange dynamics involving a sparsely populated (p ~ 10%) and shortly lived (τ ~ 10 ms) NMR “invisible” state. The utility of CEST and low spin-lock field R1ρ RD experiments in studying slow exchange was further validated in characterizing an exchange as slow as ~60 s−1.
ASSOCIATED WITH THE EDUCATIONAL PERSPECTIVE ON NEW NORMAL ADAPTATION DOCUMENT REPLICATED
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences

description: ASSOCIATED WITH THE EDUCATIONAL PERSPECTIVE ON NEW NORMAL ADAPTATION DOCUMENT REPLICATED
THIS DOCUMENT WAS ADOPTED FROM THE EUROPEAN COMMISSION AND IS ENTITLED Program to adapt the educational system to the digital generation
Leveraging selective peptoid degradation for biosensing applications
Creators: name: McKenzie, Hattie Christine (Schunk)
name: 0000-0002-4768-2569
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Peptoids
Reactive oxygen species
Degradation
Sequence-defined
Biosensing

description: Development of multi-functional materials and biosensors that can achieve an in-situ response designed by the user is a current need in the biomaterials field, especially in complex biological environments, such as inflammation, where multiple enzymatic and oxidative signals are present. In the past decade, there has been extensive research and development of materials chemistries for detecting and monitoring enzymatic activity, as well as for releasing therapeutic and diagnostic agents in regions undergoing oxidative stress. However, there has been limited development of materials in the context of enzymatic and oxidative triggers together, despite their closely tied and overlapping mechanisms. One major fundamental design challenge to integrating multiple sensing elements in tandem is instability and uncontrolled cross-reactivity. Thus, to successfully detect biomarkers in synergy, there is need for innovative strategies in controlling biostability while maintaining well-defined bioactivity. We aim to address this challenge using synthetic, sequence-defined peptoids. Due to their N-substitution, peptoids are generally regarded as resistant to biological degradation, such as enzymatic and hydrolytic mechanisms. This stability is an especially attractive feature for therapeutic development and is a selling point of many previous biological studies. However, oxidative degradation of peptoids mediated by reactive oxygen and nitrogen species (ROS/RNS) is key mode of degradation that remains to be fully explored. ROS and RNS are biologically relevant in numerous contexts where biomaterials may be present, thus, improving understanding of peptoid oxidative susceptibility is crucial to exploit their full potential in the biomaterials field. Toward this end, we demonstrate a fundamental characterization of sequence-defined peptoid chains in the presence of chemically generated ROS, as compared to ROS-susceptible peptides such as proline and lysine oligomers. These results expand understanding of peptoid degradation to oxidative and enzymatic mechanisms, and demonstrate the potential for peptoid incorporation into materials where selectivity towards oxidative degradation is necessary, or directed enzymatic susceptibility is desired. By considering the materials chemistry of enzymatically and oxidatively triggered biomaterials in tandem, we hope to encourage synthesis of new biosensors that capitalize on their synergistic roles and overlapping mechanisms in inflammatory environments for future applications in disease diagnosis and monitoring.
Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on in Vivo Circulation of Polyelectrolyte Microgels
Creators: name: Chen, Kai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Lowering the modulus of hydrogel particles could enable them to bypass in vivo physical barriers that would otherwise filter particles with similar size but higher modulus. Incorporation of electrolyte moieties into the polymer network of hydrogel particles to increase the swelling ratio is a straightforward and quite efficient way to decrease the modulus. In addition, charged groups in hydrogel particles can also help secure cargoes. However, the distribution of charged groups on the surface of a particle can accelerate the clearance of particles. Herein, we developed a method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups. A strategy was employed to enable a particle to be highly cross-linked with very small mesh size, and subsequently PEGylated to quench the exterior amines only without affecting the internal amines. Acidic degradation of the cross-linker allows for swelling of the particles to microgels with a desired size and deformability. The microgels fabricated demonstrated extended circulation in vivo compared to their counterparts with a charged surface, and could potentially be utilized in in vivo applications including as oxygen carriers or nucleic acid scavengers.
B 12 -Mediated, Long Wavelength Photopolymerization of Hydrogels
Creators: name: Hughes, Robert M.
name: Shell, Jennifer R.
name: Lawrence, David S.
name: Brugh, Alexander M.
name: Forbes, Malcolm D. E.
name: Rodgers, Zachary L.
name: Molesky, Brian P.
name: Moran, Andrew M.
name: Doherty, Laura M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by non-invasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-crosslinking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600 - 900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photo-activation occurs within a range of skin type models containing high biochromophore concentrations.
MUSER: A Multi-View Similar Case Retrieval Dataset
Creators: name: Li, Qingquan
name: Hu, Yiran
name: Yao, Feng
name: Xiao, Chaojun
name: Liu, Zhiyuan
name: Sun, Maosong
name: Shen, Weixing
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Similar case retrieval (SCR) is a representative legal AI application that plays a pivotal role in promoting judicial fairness. However, existing SCR datasets only focus on the fact description section when judging the similarity between cases, ignoring other valuable sections (e.g., the court's opinion) that can provide insightful reasoning process behind. Furthermore, the case similarities are typically measured solely by the textual semantics of the fact descriptions, which may fail to capture the full complexity of legal cases from the perspective of legal knowledge. In this work, we present MUSER, a similar case retrieval dataset based on multi-view similarity measurement and comprehensive legal element with sentence-level legal element annotations. Specifically, we select three perspectives (legal fact, dispute focus, and law statutory) and build a comprehensive and structured label schema of legal elements for each of them, to enable accurate and knowledgeable evaluation of case similarities. The constructed dataset originates from Chinese civil cases and contains 100 query cases and 4,024 candidate cases. We implement several text classification algorithms for legal element prediction and various retrieval methods for retrieving similar cases on MUSER. The experimental results indicate that incorporating legal elements can benefit the performance of SCR models, but further efforts are still required to address the remaining challenges posed by MUSER. The source code and dataset are released at https://github.com/THUlawtech/MUSER.
description: Accepted by CIKM 2023 Resource Track
String breaking and running coupling of $\rm Q\bar{Q}$ in a rotating media from holography
Creators: name: Zhou, Jing
name: Zhang, Saiwen
name: Chen, Jun
name: Zhang, Le
name: Chen, Xun
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Through gravity/gauge duality, the string breaking and running coupling constant of heavy quark-antiquark pair are investigated in the rotating background. For the meson decay mode $\rm Q\bar{Q} \rightarrow Q \bar{q}+\bar{Q} q$, we discuss the string breaking and running coupling in the parallel and transverse case. It is found that the parallel case has a more significant on string breaking and running coupling constant than the transverse case in the confined phase. The string-breaking distance and the maximum value of running coupling will decrease with the increase of angular velocity in the parallel case. Besides, we also investigate the running coupling and screening distance at finite angular velocity in the deconfined phase. It is found that the maximum values of the running coupling and screening distance are decreasing functions of angular velocity. The parallel case has a more significant influence on the running coupling and screening distance than the transverse case in the deconfined phase.
Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity
Creators: name: Lee, Andrew L.
name: Sapienza, Paul J.
name: Falk, Bradley T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Thymidylate synthase (TSase) is a clinically important enzyme because it catalyzes synthesis of the sole de novo source of deoxy-thymidylate. Without this enzyme, cells die a “thymineless death” since they are starved of a crucial DNA synthesis precursor. As a drug target, TSase is well studied in terms of its structure and reaction mechanism. An interesting mechanistic feature of dimeric TSase is that it is “half-the-sites reactive”, which is a form of negative cooperativity. Yet, the basis for this is not well-understood. Some experiments point to cooperativity at the binding steps of the reaction cycle as being responsible for the phenome non but the literature contains conflicting reports. Here we Contrary to these reports are the x-ray models of TSase, which for the case of the E. coli enzyme, have yet to capture detailed thermodynamic dissection of multi-site binding of dUMP to E. coli TSase shows the nucleotide binds to the free and singly bound forms of the enzyme with nearly equal affinity over a broad range of temperatures and in multiple buffers. While small but significant differences in ΔC°P for the two binding events show that the active sites are not formally equivalent, there is little-to-no allostery at the level of ΔG°bind. In addition NMR titration data reveal that there is minor inter-subunit cooperativity in formation of a ternary complex with the mechanism based inhibitor, 5F-dUMP, and cofactor. Taken together, the data show that functional communication between subunits is minimal for both binding steps of the reaction coordinate.
A RAW DATA FULL TEXT2.pdf
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2021
Subjects: subject: 200101 Communication Studies
subject: FOS: Media and communications
subject: 200302 English Language
subject: FOS: Languages and literature
subject: 200303 English as a Second Language
subject: 200399 Language Studies not elsewhere classified

description: The process of learning English as a foreign language is a complete stage for the third
circle community. Indonesia is one of the countries where learning English as a foreign
language is compulsory based on National Regulation of Educational System. In addition,
Indonesia consists of a thousand islands, one of the largest archipelagic countries in the world.
However, not all educational processes fulfil the purpose of education at the national level.
There is still a need to reform the obstacle of the educational process and the teaching and
learning of English as a foreign language, from elementary level to higher educational
institution. Therefore, through the second literacy sources, I proposed this literacy through
the format of raw data to enrich the knowledge of the sixteen tenses of English language,
which support each session of teaching and learning besides the main sources of English
language teaching and learning module.
Indices of Agricultural Production for Europe and the USSR: Average 1961-65 and Annual 1965 Through 1974
Creators: name: Demand, Foreign
name: Demand, Foreign
Publisher: name: Unknown
Year: 1975
Subjects: Crop Production/Industries
Livestock Production/Industries
Productivity Analysis
Research Methods/ Statistical Methods

description: Excerpts from the report Introduction: Europe and the USSR produce and consume a large share of the world's food and fiber. Assessment of the agricultural and food situation in these areas is basic to a knowledge of world production, consumption, and trade in food and fibers. The indices presented in this publication are a part of the continuing effort of the Economic Research Service (ERS) to assess the world agricultural situation. The country indices are calculated by Laspeyres' base-weighted aggregate formula. The weights used in Eastern Europe and the Soviet Union are estimates of the 1961-65 average prices received by farmers in Western Europe, and for West European countries they are the average base period prices received by farmers in each of the individual countries, expressed in U.S. dollars per metric ton. Regional indices are computed from sums of country aggregates. Only those agricultural products of considerable significance in the respective countries are included. Production data are listed under the year in which the bulk of the harvest occurred.
Estrategias para desarrollar una comunidad local de ciencia abierta: El caso del Grupo de Trabajo sobre Ciencia Abierta de la Concordia University
Creators: name: Alessandroni, Nicolás
name: Byers-Heinlein, Krista
Publisher: name: Zenodo
Year: 2022
Subjects: ciencia abierta
comunidades
cultura científica
estrategias institucionales

description: Diapositivas de la comunicación oral "Estrategias para desarrollar una comunidad local de ciencia abierta: El caso del Grupo de Trabajo sobre Ciencia Abierta de la Concordia University" aceptada para ser presentada en el Congreso Iberoamericano de Ciencia Abierta (23 y 24 de noviembre de 2022).
perbaikan.pdf
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences

description: ASSOCIATED WITH THE EDUCATIONAL PERSPECTIVE ON NEW NORMAL ADAPTATION DOCUMENT REPLICATED
THIS DOCUMENT WAS ADOPTED FROM THE EUROPEAN COMMISSION AND IS ENTITLED Program to adapt the educational system to the digital generation
SOAP 2.0: A tool to estimate the photometric and radial velocity variations induced by stellar spots and plages
Creators: name: Dumusque, X.
name: Boisse, I .
name: Santos, N. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: This paper presents SOAP 2.0, a new version of the SOAP code that estimates in a simple way the photometric and radial velocity variations induced by active regions. The inhibition of the convective blueshift inside active regions is considered, as well as the limb brightening effect of plages, a quadratic limb darkening law, and a realistic spot and plage contrast ratio. SOAP 2.0 shows that the activity-induced variation of plages is dominated by the inhibition of the convective blueshift effect. For spots, this effect becomes significant only for slow rotators. In addition, in the case of a major active region dominating the activity-induced signal, the ratio between the full width at half maximum (FWHM) and the RV peak-to-peak amplitudes of the cross correlation function can be used to infer the type of active region responsible for the signal for stars with \vsini$\le8$\kms. A ratio smaller than three implies a spot, while a larger ratio implies a plage. Using the observation of HD189733, we show that SOAP 2.0 manages to reproduce the activity variation as well as previous simulations when a spot is dominating the activity-induced variation. In addition, SOAP 2.0 also reproduces the activity variation induced by a plage on the slowly rotating star $α$ Cen B, which is not possible using previous simulations. Following these results, SOAP 2.0 can be used to estimate the signal induced by spots and plages, but also to correct for it when a major active region is dominating the RV variation.
description: 28 pages, 15 figures, accepted for publication in ApJ after minor revisions (taken into account in this version)
title: Musica dell’anima o musica del cosmo?
Creators: name: Matassi , Elio
Publisher: name: Roma Tre-Press
Year: 2012

description: Il contributo intende render conto brevemente del concetto di musica così come Bloch lo commisura all'uomo, autentica oggettificazione della vita interiore, sottolineando la profonda frattura aperta dalla posizione blochiana rispetto alla tradizionale interpretazione della musica come armonia pitagorico-kepleriana impressa da Dio al cosmo, la quale è l'origine delle forse meglio conosciute teorie di Schopenhauer (la musica suona l'essenza del mondo) e di Schelling (la musica è espressione dell'eterno movimento dei corpi celesti).

description: B@belonline vol. 13 Chaos/Kosmos
The Revival of Population Growth in Nonmetropolitan America
Creators: name: Beale, Calvin L.
name: Beale, Calvin L.
Publisher: name: Unknown
Year: 1975
Subjects: Community/Rural/Urban Development
Labor and Human Capital

description: Population grew faster in nonmetro than in metro counties between 1970 and 1973. This trend reverses the previous pattern of inmigration to cities. Among the reasons for increases in rural areas and small towns are decentralization of manufacturing and other industry; increased settlement of retired people; expansion of State colleges; more recreation activity; and apparent higher birthrate in nonmetro areas. Also, urban areas have lost their appeal for many people.
description: This report is based on a paper presented at the Conference on Population Distribution, sponsored by the Center for Population Research, National Institutes of Health, Belmont, Md., January 29-31, 1975.
Exploitation des propri{é}t{é}s de saturation synaptique pour obtenir un neurone {à} fr{é}quence sp{é}cifique
Creators: name: Marthe, Guillaume
name: Goursaud, Claire
Publisher: name: arXiv
Year: 2023
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Energy consumption remains the main limiting factors in many promising IoT applications. In particular, micro-controllers consume far too much power. In order to overcome this problem, new circuit designs have been proposed and the use of spiking neurons and analog computing has emerged as it allows a very significant consumption reduction. However, working in the analog domain brings difficulty to handle the sequential processing of incoming signals as is needed in many use cases.In this paper, we propose to use a bio-inspired phenomenon called Interacting Synapses to produce a time filter. We propose a model of synapses that makes the neuron fire for a specific range of delays between two incoming spikes, but not react when this Inter-Spike Timing is not in that range. We study the parameters of the model to understand how to adapt the Inter-Spike Timing. The originality of the paper is to propose a new way, in the analog domain, to deal with temporal sequences.
description: in French language
Stochastic Geometry Modeling and Analysis of Multi-Tier Millimeter Wave Cellular Networks
Creators: name: Di Renzo, Marco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, a new mathematical framework to the analysis of millimeter wave cellular networks is introduced. Its peculiarity lies in considering realistic path-loss and blockage models, which are derived from recently reported experimental data. The path-loss model accounts for different distributions of line-of-sight and non-line-of-sight propagation conditions and the blockage model includes an outage state that provides a better representation of the outage possibilities of millimeter wave communications. By modeling the locations of the base stations as points of a Poisson point process and by relying on a noise-limited approximation for typical millimeter wave network deployments, simple and exact integral as well as approximated and closed-form formulas for computing the coverage probability and the average rate are obtained. With the aid of Monte Carlo simulations, the noise-limited approximation is shown to be sufficiently accurate for typical network densities. The proposed mathematical framework is applicable to cell association criteria based on the smallest path-loss and on the highest received power. It accounts for beamforming alignment errors and for multi-tier cellular network deployments. Numerical results confirm that sufficiently dense millimeter wave cellular networks are capable of outperforming micro wave cellular networks, both in terms of coverage probability and average rate.
description: Submitted to IEEE Transactions on Wireless Communications
Active Faraday optical frequency standards
Creators: name: Zhuang, Wei
name: Chen, Jingbiao
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We propose the mechanism of active Faraday optical clock, and experimentally demonstrate active Faraday optical frequency standards based on 852 nm narrow bandwidth Faraday atomic filter by the method of velocity-selective optical pumping of cesium vapor. The center frequency of the active Faraday optical frequency standards is determined by the cesium 6 $^{2}S_{1/2}$ $F$ = 4 to 6 $^{2}P_{3/2}$ $F'$ = 4 and 5 crossover transition line. The optical heterodyne beat between two similar independent setups shows that the frequency linewidth reaches 996(26) Hz, which is 5.3 $\times$ 10$^{3}$ times smaller than the natural linewidth of the cesium 852 nm transition line. The maximum emitted light power reaches 75 $\upmu$W. The active Faraday optical frequency standards reported here have advantages of narrow linewidth and reduced cavity pulling, which can readily be extended to other atomic transition lines of alkali and alkaline-earth metal atoms trapped in optical lattices at magic wavelengths, making it useful for new generation of optical atomic clocks.
description: 4 pages, 4 figures