cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
First Energy and Angle differential Measurements of e^+e^- -pairs emitted by Internal Pair Conversion of excited Heavy Nuclei
Creators: name: Leinberger, U.
name: Berdermann, E.
name: Heine, F.
name: Heinz, S.
name: Joeres, O.
name: Kienle, P.
name: Koenig, I.
name: Koenig, W.
name: Kozhuharov, C.
name: Schroeter, A.
name: Tsertos, H.
name: Hofmann, C.
name: Soff, G.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We present the first energy and angle resolved measurements of e+e- pairs emitted from heavy nuclei (Z>=40) at rest by internal pair conversion (IPC) of transitions with energies of less than 2MeV as well as recent theoretical results using the DWBA method, which takes full account of relativistic effects, magnetic substates and finite size of the nucleus. The 1.76MeV E0 transition in Zr90 (Sr source) and the 1.77MeV M1 transition in Pb207 (Bi source) have been investigated experimentally using the essentially improved set-up at the double-ORANGE beta-spectrometer of GSI. The measurements prove the capability of the setup to cleanly identify the IPC pairs in the presence of five orders of magnitude higher beta- and gamma background from the same source and to yield essentially background-free sum spectra despite the large background. Using the ability of the ORANGE setup to directly determine the opening angle of the e+e- pairs, the angular correlation of the emitted pairs was measured. In the Zr90 case the correlation could be deduced for a wide range of energy differences of the pairs. The Zr90 results are in good agreement with recent theory. The angular correlation deduced for the M1 transition in Pb207 is in strong disagreement with theoretical predictions derived within the Born approximation and shows almost isotropic character. This is again in agreement with the new theoretical results.
description: LaTeX, 28 pages incl. 10 PS figures; Accepted by Z.Phys.A
title: Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions
Creators: name: Thürmann, Loreen
name: Klös, Matthias
name: Mackowiak, Sebastian D.
name: Bieg, Matthias
name: Bauer, Tobias
name: Ishaque, Naveed
name: Messingschlager, Marey
name: Herrmann, Carl
name: Röder, Stefan
name: Bauer, Mario
name: Schäuble, Sascha
name: Faessler, Erik
name: Hahn, Udo
name: Weichenhan, Dieter
name: Mücke, Oliver
name: Plass, Christoph
name: Borte, Michael
name: Von Mutius, Erika
name: Stangl, Gabriele I.
name: Lauener, Roger
name: Karvonen, Anne M.
name: Divaret‐Chauveau, Amandine
name: Riedler, Josef
name: Heinrich, Joachim
name: Standl, Marie
name: Von Berg, Andrea
name: Schaaf, Beate
name: Herberth, Gunda
name: Kabesch, Michael
name: Eils, Roland
name: Trump, Saskia
name: Lehmann, Irina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: asthma
subject: cord blood
subject: DNA-methylation
subject: prenatal exposure
classificationCode: 610
subject: Medizin und Gesundheit

description: Background Childhood asthma is a result of a complex interaction of genetic and environmental components causing epigenetic and immune dysregulation, airway inflammation and impaired lung function. Although different microarray based EWAS studies have been conducted, the impact of epigenetic regulation in asthma development is still widely unknown. We have therefore applied unbiased whole genome bisulfite sequencing (WGBS) to characterize global DNA-methylation profiles of asthmatic children compared to healthy controls. Methods Peripheral blood samples of 40 asthmatic and 42 control children aged 5–15 years from three birth cohorts were sequenced together with paired cord blood samples. Identified differentially methylated regions (DMRs) were categorized in genotype-associated, cell-type-dependent, or prenatally primed. Network analysis and subsequent natural language processing of DMR-associated genes was complemented by targeted analysis of functional translation of epigenetic regulation on the transcriptional and protein level. Results In total, 158 DMRs were identified in asthmatic children compared to controls of which 37% were related to the eosinophil content. A global hypomethylation was identified affecting predominantly enhancer regions and regulating key immune genes such as IL4, IL5RA, and EPX. These DMRs were confirmed in n = 267 samples and could be linked to aberrant gene expression. Out of the 158 DMRs identified in the established phenotype, 56 were perturbed already at birth and linked, at least in part, to prenatal influences such as tobacco smoke exposure or phthalate exposure. Conclusion This is the first epigenetic study based on whole genome sequencing to identify marked dysregulation of enhancer regions as a hallmark of childhood asthma.
title: Morphologische muskuläre und tendinöse Adaptionen nach Achillessehnenrupturen: eine prospektive MRT-Analyse
Creators: name: Gehlen, Tobias
name: Tsitsilonis, Serafeim
name: Kurtoglu, Alper
name: Manegold, Sebastian
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Achillessehne
subject: MRT
subject: fettige Degeneration
subject: Sehnenlänge
subject: 610 Medical sciences; Medicine

description: Fragestellung: Nach einer Achillessehnenruptur können funktionelle Defizite auf der operierten Seite bis zu 14 Jahren nachweisbar sein. Die Gründe dafür bleiben weiterhin unklar. Die vorliegende Studie ist die erste, die prospektiv mittels repetitiver MRT-Untersuchungen die Dynamik der[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
title: The pan‐JAK inhibitor delgocitinib in a cream formulation demonstrates dose response in chronic hand eczema in a 16‐week randomized phase IIb trial
Creators: name: Worm, Margitta
name: Thyssen, Jacob P.
name: Schliemann, Sibylle
name: Bauer, Andrea
name: Shi, Vivian Y.
name: Ehst, Ben
name: Tillmann, Sandra
name: Korn, Sofie
name: Resen, Katarina
name: Agner, Tove
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: dermatitis, atopic
subject: double-blind method
subject: eczema
subject: immunoglobulin A
classificationCode: 610
subject: Medizin und Gesundheit

description: Background Chronic hand eczema (CHE) is a burdensome disease, and new well‐documented, safe and efficacious treatments are warranted. In a recent CHE phase IIa trial, the pan‐Janus kinase (JAK) inhibitor delgocitinib in an ointment formulation was found to be efficacious and well tolerated. Objectives This trial assessed the dose response, efficacy and safety of delgocitinib cream in CHE. Methods In this double‐blind, phase IIb dose‐ranging trial, adults with CHE and a recent history of inadequate response or contraindication to topical corticosteroids were randomized to delgocitinib cream 1, 3, 8, 20 mg g–1 or vehicle treatment twice daily for 16 weeks. The primary endpoint was the Investigator’s Global Assessment for CHE (IGA‐CHE) treatment success [0 (clear) or 1 (almost clear) with a ≥ two‐point improvement from baseline to week 16]. Secondary endpoints were the time to IGA‐CHE treatment success and changes in Hand Eczema Severity Index (HECSI); other endpoints were itch and pain numerical rating scale (NRS) scores, and Patient’s Global Assessment (PaGA) at week 16. Results Patients (n = 258) were randomized 1 : 1 : 1 : 1 : 1 to delgocitinib cream 1, 3, 8, 20 mg g–1 or vehicle. A significant dose–response relationship was established for IGA‐CHE (P < 0.025). IGA‐CHE treatment success at week 16 was achieved in 21.2% (1 mg g–1), 7.8% (3 mg g–1), 36.5% (8 mg g–1), 37.7% (20 mg g–1) and 8.0% (vehicle) of patients. Delgocitinib 8 and 20 mg g–1 showed a treatment effect against vehicle (P < 0.001). Similarly, there were improvements in HECSI, itch and pain NRS scores, and PaGA. Delgocitinib cream was well tolerated with the majority of adverse events being mild or moderate and considered unrelated to treatment. The most frequently reported adverse events were nasopharyngitis (17.3–29.4% in delgocitinib groups vs. 40% in vehicle group), eczema (5.8–11.3% in delgocitinib groups vs. 16.0% in vehicle group) and headache (3.8–11.5% in delgocitinib groups vs. 4.0% in vehicle group). Conclusions In this trial, delgocitinib cream showed a dose–response relationship in terms of efficacy and was well tolerated.
Measuring the Rate of Isotropization of Quark-Gluon Plasma Using Rapidity Correlations
Creators: name: Moschelli, George
name: Gavin, Sean
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose that rapidity dependent momentum correlations can be used to extract the shear relaxation time $τ_π$ of the medium formed in high energy nuclear collisions. The stress-energy tensor in an equilibrium quark-gluon plasma is isotropic, but in nuclear collisions it is likely very far from this state. The relaxation time $τ_π$ characterizes the rate of isotropization and is a transport coefficient as fundamental as the shear viscosity. We show that fluctuations emerging from the initial anisotropy survive to freeze-out, in excess of thermal fluctuations, influencing rapidity correlation patterns. We show that these correlations can be used to extract $τ_π$. We describe a method for calculating the rapidity dependence of two-particle momentum correlations with a second order, causal, diffusion equation that includes Langevin noise as a source of thermal fluctuations. The causality requirement introduces the relaxation time and we link the shape of the rapidity correlation pattern to its presence. Here we examine how different equations of state and temperature dependent transport coefficients in the presence of realistic hydrodynamic flow influence the estimate of $τ_π$. In comparison to RHIC data, we find that the ratio $τ_π/ν\approx 5-6$ where $ν=η/sT$ is the kinematic viscosity.
description: Proceedings of The 27th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions, Venezia, Italy 13-19 May 2018
Extralevator with vs nonextralevator abdominoperineal excision for rectal cancer.docx
Creators: name: Ivanova, Anna
Publisher: name: figshare
Year: 2018
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: AIM:
 A randomized controlled trial was conducted to test the null hypothesis that there is no difference in circumferential resection margin (CRM) between extralevator abdominoperineal excision (ELAPE) and non-ELAPE for rectal cancer.

 METHOD:
 This was a multicentre, randomized controlled trial registered as NCT01702116. Patients with rectal cancer involving the external anal sphincter were randomized to ELAPE or non-ELAPE following neoadjuvant chemoradiation. Randomization was performed according to Consolidated Standards of Reporting Trials (CONSORT) guidelines. The primary end-point was CRM (in mm), defined as the shortest distance between the tumour and the cut edge of the specimen. Pathologists and centralized pathology were blinded to the patients' study arm. Interrater reliability (IRR) was assessed using Kendall's coefficient. Intra-operative perforation (IOP) was any rectal defect determined at pathology. Complications were classified using the Clavien-Dindo classification. Participating surgeons were retrained and credentialed. A sample size calculation showed that 34 subjects would provide sufficient power to reject the null hypothesis.

 RESULTS:
 Thirty-four patients underwent the allocated intervention. Seventeen patients treated with ELAPE were comparable with 17 patients treated with non-ELAPE regarding age, gender, body mass index (BMI), American Society of Anesthesiology (ASA) class and pre-existing comorbidities. CRM depth (7.14 ± 5.76 mm vs 2.98 ± 3.28 mm, P = 0.016) and involvement rates (5.8% vs 41.0%, P = 0.04) were significantly increased in patients treated with ELAPE. The IRR for CRM was 0.78. There were no significant differences in IOP (5.8% vs 11.7%, P = 0.77) and complication rates (29% vs 29%, P = 0.97).

 CONCLUSIONS:
 ELAPE was associated with statistically improved CRM with no difference in IOP and complication rates compared with non-ELAPE for rectal cancer involving the external anal sphincter.
Non-thermal nature of photo-induced insulator-to-metal transition in NbO$_2$
Creators: name: Rana, Rakesh
name: Klopf, J. Michael
name: Grenzer, Jörg
name: Schneider, Harald
name: Helm, Manfred
name: Pashkin, Alexej
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the photo-induced metallization process in niobium dioxide NbO$_2$. This compound undergoes the thermal insulator-to-metal transition at the remarkably high temperature of 1080 K. Our optical pump - terahertz probe measurements reveal the ultrafast switching of the film on a sub-picosecond timescale and the formation of a metastable metallic phase when the incident pump fluence exceeds the threshold of 10 mJ/cm$^2$. Remarkably, this threshold value corresponds to the deposited energy which is capable of heating NbO$_2$ only up to 790 K, thus, evidencing the non-thermal character of the photo-induced insulator-to-metal transition. We also observe an enhanced formation of the metallic phase above the second threshold of 17.5 mJ/cm$^2$ which corresponds to the onset of the thermal switching. The transient optical conductivity in the metastable phase can be modeled using the Drude-Smith model confirming its metallic character. The present observation of non-thermal transition in NbO$_2$ can serve as an important test bed for understanding photo-induced phenomena in strongly correlated oxides.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 682
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 682, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 682, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
title: Doctor, when can I drive? Empfehlungen zur Fahrtauglichkeit bei Erkrankungen des Bewegungs- und Stützapparates
Creators: name: Latz, David
name: Schiffner, Erik
name: Schneppendahl, Johannes
name: Thalmann, Ben Hannes
name: Jungbluth, Pascal
name: Grassmann, Jan
name: Windolf, Joachim
name: Gehrmann, Sebastian
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Verkehrsmedizin
subject: Unfallchirurgie
subject: Kraftfahrereignung
subject: Fahrtauglichkeit
subject: Rechtsmedizin
subject: 610 Medical sciences; Medicine

description: Fragestellung: Das Führen eines Kfz ist zu einem wichtigen sozioökonomischen Aspekt unserer Gesellschaft und maßgeblichem Bestandteil der persönlichen Mobilität geworden. Es existieren jedoch nur wenige Studien, welche zur evidenzbasierten Beurteilung der Fahrtauglichkeit bei[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
Spectroscopy of Local Density of States Fluctuations in a Disordered Conductor (Experiment)
Creators: name: Schmidt, T.
name: Haug, R. J.
name: Fal'ko, V. I.
name: Klitzing, K. v.
name: Foerster, A.
name: Lueth, H.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The local density of states of a degenerate semiconductor is investigated at low magnetic fields. In order to realize this experiment, we designed a strongly asymmetric double-barrier heterostructure with heavily doped contacts and study the resonant tunneling transport through the lowest localized (zero-dimensional) level in the quantum well. Fine structure in the tunneling current as a function of bias voltage and magnetic field images mesoscopic fluctuations of the local density of states in the emitter contact. Our quantitative analysis demonstrates that the fluctuation pattern originates from quantum interference of diffusive electron waves in the three-dimensional disordered system on the length scale of the mean free path. Since the fluctuations reflect the properties of the electron states below the Fermi level, the observed mesoscopic effect is temperature insensitive.
description: RevTex, 10 pages, 5 ps-figures
title: Der Wert des intraoperativen Gefrierschnittes in der Diagnostik von periprothetischen Gelenksinfektionen
Creators: name: Sigmund, Irene Katharina
name: Holinka, Johannes
name: Lang, Susanna
name: Stenicka, Sandra
name: Staats, Kevin
name: Hobusch, Gerhard
name: Kubista, Bernd
name: Windhager, Reinhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Gefrierschnitt
subject: periprothetische Gelenksinfektion
subject: Diagnostik
subject: Histologie
subject: 610 Medical sciences; Medicine

description: Fragestellung: Periprothetische Gelenksinfektionen (PPI) zählen aufgrund der schwierigen Diagnostik zu den gefürchtetsten Komplikationen in der Endoprothetik. Oftmals kann nach Erhebung der präoperativen Tests noch keine definitive Aussage getroffen werden, ob eine periprothetische Infektion[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
Слово об учителе. Памяти замечательного педагога и ученного М.Р. Сапина.docx
Creators: name: Ivanova, Anna
Publisher: name: figshare
Year: 2018
Subjects: subject: 130209 Medicine, Nursing and Health Curriculum and Pedagogy
subject: FOS: Educational sciences

description: Михаил Романович Сапин профессор Первого Московского государственного медицинского университета им . И . М . Сеченова , почетный академик Российской академии медицинских наук с 1988 г ., Выдающийся представитель Московской анатомической школы середины XX начала XXI в.
Exploding neutron stars in close binaries
Creators: name: Blinnikov, S. I.
name: Novikov, I. D.
name: Perevodchikova, T. V.
name: Polnarev, A. G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The discovery of GW signal from merging neutron stars by LIGO on 17th August 2017 was followed by a short GRB170817A discovered by FERMI and INTEGRAL 1.7 seconds after the loss of the GW signal when it just reached its maximum. Here we present a reproduction of the first paper (published by us in 1984) predicting a short GRB after GW signal of merging neutron stars. Our paper followed the scenario by Clark and Eardley (1977) who predicted a catastrophic disruption of a neutron star in a binary 1.7 seconds after the peak of GW signal. Our next paper in 1990 predicted all the main properties of the short GRB with quite a reasonable accuracy. Typos in English translation are corrected and a few comments are added in the current publication as numbered footnotes (the only footnote from the original paper is marked by an asterisk).
description: LaTeX, 7 pages; typo in eq.18 corrected, affiliations added
title: Titanpfannendeformation unter dynamischer Belastung in der Primär- und Revisionssituation
Creators: name: Beckmann, Nicholas
name: Bitsch, Rudi
name: Janoszka, Maciej
name: Braun, Steffen
name: Schwarze, Martin
name: Omlor, Georg
name: Jäger, Sebastian
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Hüftendoprothetik
subject: Acetabulum
subject: Implantat
subject: Deformation
subject: 610 Medical sciences; Medicine

description: Fragestellung: Zementfreie azetabuläre Implantate haben eine weite Akzeptanz und Verwendung in der Hüft Endoprothetik erzielt. Press-fit Verankerung ist die Standardmethode der Verankerung, ggf mit oder ohne zusätzlicher Schrauben. Übergroße Pfannen und/oder Augment können[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
Design and optimisation of an efficient HDF5 I/O kernel for massive parallel fluid flow simulations
Creators: name: Ertl, Christoph
name: Frisch, Jérôme
name: Mundani, Ralf-Peter
Publisher: name: arXiv
Year: 2018
Subjects: subject: Performance (cs.PF)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences
subject: C.4; E.1; D.1.3; I.6.8

description: More and more massive parallel codes running on several hundreds of thousands of cores enter the computational science and engineering domain, allowing high-fidelity computations on up to trillions of unknowns for very detailed analyses of the underlying problems. During such runs, typically gigabytes of data are being produced, hindering both efficient storage and (interactive) data exploration. Here, advanced approaches based on inherently distributed data formats such as HDF5 become necessary in order to avoid long latencies when storing the data and to support fast (random) access when retrieving the data for visual processing. Avoiding file locking and using collective buffering, write bandwidths to a single file close to the theoretical peak on a modern supercomputing cluster were achieved. The structure of the output file supports a very fast interactive visualisation and introduces additional steering functionality.
description: 24 pages, 8 figures
Large Yukawa coupling corrections to scalar quark pair production in $e^+e^-$ annihilation
Creators: name: Bi, Xiao-Jun
name: Dai, Yuan-Ben
name: Qi, Xiao-Yuan
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the large Yukawa coupling corrections to the top and bottom scalar quark pair production in $\ee$ annihilation within the Minimal Supersymmetric Standard Model. We include the vertex corrections and the corrections to the gauge boson propagator enhanced by large masses. We find the total corrections are quite significant. In some regions of the parameter space the corrections are larger than 10%.
description: RevTex, 25 pages, 16 figures
Additional file 1 of Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations
Creators: name: Asadi, Mehdi
name: Fayazi, Fahime
name: Iraji, Aida
name: Sabourian, Reyhaneh
name: Azizian, Homa
name: Hajimahmoodi, Mannan
name: Larijani, Bagher
name: Mahdavi, Mohammad
name: Amanlou, Massoud
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: The Supplementary Information file contains NMR spectra.
Final-State Phases in Charmed Meson Two-Body Nonleptonic Decays
Creators: name: Rosner, Jonathan L.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Observed decay rates indicate large phase differences among the amplitudes for the charge states in $D \to \bar K π$ and $D \to \bar K^* π$ but relatively real amplitudes in the charge states for $D \to \bar K ρ$. This feature is traced using an SU(3) flavor analysis to a sign flip in the contribution of one of the amplitudes contributing to the latter processes in comparison with its contribution to the other two sets. This amplitude may be regarded as an effect of rescattering and is found to be of magnitude comparable to others contributing to charmed particle two-body nonleptonic decays.
description: 19 pages, latex, 4 figures, to be submitted to Phys. Rev. D
The polarization mode of the auroral radio emission from the early-type star HD142301
Creators: name: Leto, P.
name: Trigilio, C.
name: Oskinova, L. M.
name: Ignace, R.
name: Buemi, C. S.
name: Umana, G.
name: Cavallaro, F.
name: Ingallinera, A.
name: Bufano, F.
name: Phillips, N. M.
name: Agliozzo, C.
name: Cerrigone, L.
name: Todt, H.
name: Riggi, S.
name: Leone, F.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the detection of the auroral radio emission from the early-type magnetic star HD142301. New VLA observations of HD142301 detected highly polarized amplified emission occurring at fixed stellar orientations. The coherent emission mechanism responsible for the stellar auroral radio emission amplifies the radiation within a narrow beam, making the star where this phenomenon occurs similar to a radio lighthouse. The elementary emission process responsible for the auroral radiation mainly amplifies one of the two magneto-ionic modes of the electromagnetic wave. This explains why the auroral pulses are highly circularly polarized. The auroral radio emission of HD142301 is characterized by a reversal of the sense of polarization as the star rotates. The effective magnetic field curve of HD142301 is also available making it possible to correlate the transition from the left to the right-hand circular polarization sense (and vice-versa) of the auroral pulses with the known orientation of the stellar magnetic field. The results presented in this letter have implications for the estimation of the dominant magneto-ionic mode amplified within the HD142301 magnetosphere.
description: 5 pages, 4 figures; accepted to MNRAS Letters
title: 10-Jahres-Ergebnisse nach distaler Bizepssehnenrefixation in 2-Inzisionen-Technik nach Morrey
Creators: name: Razaeian, Sam
name: Meller, Rupert
name: Krettek, Christian
name: Hawi, Nael
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Distale Bizepssehnenruptur
subject: transossäre Refixation
subject: 2-Inzisionen-Technik
subject: 610 Medical sciences; Medicine

description: Fragestellung: Distale Bizepssehnenrupturen stellen eine äußerst seltene Sehnenverletzung dar. Während hinsichtlich der operativen Therapiebedürftigkeit von Komplettrupturen wissenschaftlicher Konsens herrscht, bestehen über die Art der optimalen Zugangs- und Refixationstechnik[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
title: Long-Range Regulation by the Shigella Virulence Gene Regulator, VirB
Creators: name: Cris, Cody
Publisher: name: University of Nevada, Las Vegas
publisherIdentifier: https://ror.org/0406gha72
publisherIdentifierScheme: ROR
Year: 2023

description: Nucleoid-structuring proteins (NSPs) in bacterial cells can exert gene regulatory effects over great distances on DNA. This contrasts with the traditional view of bacterial transcriptional regulation, where transcription factors bind cis-acting regulatory sites proximal (<250 bp) to promoters to influence gene expression. In Shigella species, the histone-like nucleoid-structuring protein (H-NS) transcriptionally silences many genes on the large (~220 kb) virulence plasmid. During host colonization, however, silencing by H-NS is alleviated by the anti-silencer protein, VirB, which remodels the H-NS:DNA complex. This transcriptional anti-silencing is mediated by VirB:DNA interactions and the modulation of DNA supercoiling, which lead to the up-regulation of virulence genes. VirB is a central regulator of Shigella virulence, but the mechanistic basis for transcriptional regulation is incompletely characterized. Here, I focus on the potential for VirB to regulate transcription from remotely located DNA binding sites. Employing complementary in vivo approaches, I assessed the spatial stringency of the VirB binding site and elucidated how varying cellular VirB levels impacts regulation over different distances. I also evaluated how a molecular roadblock on DNA influences remote regulation by VirB. Additionally, I developed control tools to validate the ability of VirB to spread along DNA, an activity of VirB that putatively drives transcriptional regulation. These data are consistent with transcriptional anti-silencing being driven by VirB spreading along DNA. Overall, these findings highlight how VirB is not a conventional transcriptional regulator and broaden our perspective on transcriptional control in bacteria. Furthermore, this work contributes to our understanding of long-range gene regulatory effects, which are frequently overlooked and poorly characterized in bacteria.
title: he SCF/KIT axis in human mast cells: Capicua acts as potent KIT repressor and ERK predominates PI3K
Creators: name: Franke, Kristin
name: Kirchner, Marieluise
name: Mertins, Philipp
name: Zuberbier, Torsten
name: Babina, Magda
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: capicua
subject: KIT
subject: mast cells
subject: RTKs
subject: signal transduction
classificationCode: 610
subject: Medizin und Gesundheit

description: Background The SCF/KIT axis regulates nearly all aspects of mast cell (MC) biology. A comprehensive view of SCF-triggered phosphorylation dynamics is lacking. The relationship between signaling modules and SCF-supported functions likewise remains ill-defined. Methods Mast cells were isolated from human skin; upon stimulation by SCF, global phosphoproteomic changes were analyzed by LC–MS/MS and selectively validated by immunoblotting. MC survival was inspected by YoPro; BrdU incorporation served to monitor proliferation. Gene expression was quantified by RT-qPCR and cytokines by ELISA. Pharmacological inhibitors were supplemented by ERK1 and/or ERK2 knockdown. CIC translocation and degradation were studied in nuclear and cytoplasmic fractions. CIC's impact on KIT signaling and function was assessed following RNA interference. Results ≈5400 out of ≈10,500 phosphosites experienced regulation by SCF. The MEK/ERK cascade was strongly induced surpassing STAT5 > PI3K/Akt > p38 > JNK. Comparison between MEK/ERK's and PI3K's support of basic programs (apoptosis, proliferation) revealed equipotency between modules. In functional outputs (gene expression, cytokines), ERK was the most influential kinase. OSM and LIF production was identified in skin MCs. Strikingly, SCF triggered massive phosphorylation of a protein not associated with KIT previously: CIC. Phosphorylation was followed by CIC's cytoplasmic appearance and degradation, the latter sensitive to protease but not preoteasome inhibition. Both shuttling and degradation were ERK-dependent. Conversely, CIC-siRNA facilitated KIT signaling, functional outputs, and survival. Conclusion The SCF/KIT axis shows notable strength in MCs, and MEK/ERK as most prominent module. An inhibitory circuit exists between KIT and CIC. CIC stabilization in MCs may turn out as a therapeutic option to interfere with allergic and MC-driven diseases.
The Peculiar Velocity Correlation Function
Creators: name: Wang, Yuyu
name: Rooney, Christopher
name: Feldman, Hume A.
name: Watkins, Richard
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present an analysis of the two-point peculiar velocity correlation function using data from the CosmicFlows catalogues. The Millennium and MultiDark Planck 2 N-body simulations are used to estimate cosmic variance and uncertainties due to measurement errors. We compare the velocity correlation function to expectations from linear theory to constrain cosmological parameters. Using the maximum likelihood method, we find values of $Ω_m= 0.315^{+0.205}_{-0.135}$ and $σ_8=0.92^{+0.440}_{-0.295}$, consistent with the Planck and Wilkinson Microwave Anisotropy Probe CMB derived estimates. However, we find that the cosmic variance of the correlation function is large and non-Gaussian distributed, making the peculiar velocity correlation function less than ideal as a probe of large-scale structure.
description: 12 pages, 13 figures
Electronic Theory for the Transition from Fermi-Liquid to Non-Fermi-Liquid Behavior in High-T$_{c}$ Superconductors
Creators: name: Langer, M.
name: Schmalian, J.
name: Grabowski, S.
name: Bennemann, K. H.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We analyze the breakdown of Fermi-liquid behavior within the 2D Hubbard model as function of doping using our recently developed numerical method for the self consistent summation of bubble and ladder diagrams. For larger doping concentrations the system behaves like a conventional Fermi-liquid and for intermediate doping similar to a marginal Fermi-liquid. However, for smaller doping pronounced deviations from both pictures occur which are due to the increasing importance of the short range antiferromagnetic spin fluctuations. This is closely related to the experimental observed shadow states in the normal state of high-$T_c$ superconductors. Furthermore, we discuss the implications of our results for transport experiments.
description: 11 pages (REVTeX) with 4 figures (Postscript)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Cart. 189 (11 H 74), 316 folios, f. 0174v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Corpus Burgundiae Medii Aevi
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0174v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0174v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Состояние нитроксидпродуцирующей функции энтотелия и гипертрофия левого желудочка у больных гипертонической болезнью.docx
Creators: name: Ivanova, Anna
Publisher: name: figshare
Year: 2018
Subjects: Cardiology

description: Цель. Оценить уровни стабильных метаболитов оксида азота (NOx) в плазме крови больных гипертонической болезнью (ГБ), не получавших систематическую антигипертензивную терапию, в зависимости от наличия или отсутствия гипертрофии левого желудочка (ГЛЖ). Материал и методы. Обследованы 124 больных артериальной гипертонией (АГ): 45 мужчин и 79 женщин; средний возраст - 51,4±6,5 лет, средняя продолжительность АГ - 7,9±7,3 лет. Группу контроля составили 25 здоровых лиц: 10 мужчин и 15 женщин; средний возраст - 48,2±7,8 лет. Трансторакальную эхокардиографию проводили по стандартной методике. Типы ремоделирования миокарда ЛЖ оценивали по критериям Ganau A, 1992. Концентрацию NOx в плазме определяли методом спектрофотометрии. Статистическая обработка результатов проводилась с помощью программы Statistica 8.0. Результаты. У больных ГБ уровень NOx был достоверно выше, чем в контрольной группе - 43,2±21,7 мкмоль/л vs 28,3±9,6 мкмоль/л (p<0,05). Была выявлена положительная корреляционная связь между уровнем NOx и фактом наличия АГ (r=0,31, p<0,05). У больных ГБ ГЛЖ была диагностирована у 66,7%. В группе больных ГБ с ГЛЖ концентрация NOx, была достоверно выше, чем в группе больных ГБ без ГЛЖ - 49,9±19,3 vs 39,8±18,3 мкмоль/л, соответственно, (р<0,05) и в контрольной группе. Были выявлены прямые корреляционные связи у больных ГБ между уровнем NOx и индексом массы миокарда ЛЖ (r=0,44, р<0,05), толщиной межжелудочковой перегородки (r=0,36, р<0,05), толщиной задней стенки ЛЖ (r=0,44, р<0,05). В подгруппе больных ГБ с нормальной геометрией ЛЖ были получены наиболее низкие уровни NOx - 35,1±17,3 мкмоль/л. В подгруппах больных ГБ с концентрическим ремоделированием ЛЖ, эксцентрической и концентрической ГЛЖ уровни NOx были достоверно выше, чем в группе контроля (p<0,05). Более высокие концентрации NOx были зарегистрированы в подгруппе больных ГБ с концентрической ГЛЖ (53,9±19,1 мкмоль/л). Заключение. У больных ГБ I-II стадий отмечены повышенные уровни NOx. У больных ГБ с ГЛЖ концентрация NOx достоверно выше, чем у больных ГБ без ГЛЖ. Выявлена корреляция между индексом массы миокарда ЛЖ и NOx (r=0,44, p<0,05). Наиболее высокие уровни NOx установлены у больных ГБ при наличии концентрической ГЛЖ.
title: Präkonditionierender Proteinfilm auf Titanoberflächen in situ: Das humane Implantatproteom
Creators: name: Jäger, Marcus
name: Jennissen, Herbert P.
name: Haversath, Marcel
name: Busch, André
name: Grupp, Thomas M.
name: Herten, Monika
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Proteom
subject: Titan
subject: Hüftendoprothetik
subject: in situ
subject: 610 Medical sciences; Medicine

description: Fragestellung: Die aseptische Lockerung ist eine der häufigsten Indikationen für Revisionsoperationen in der Endoprothetik. Kausal spielen abriebbedingten Osteolysen ('particle disease') sowie die individuelle Knochenqualität hierbei eine wichtige Rolle. Dabei wird eine frühzeitige[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
title: Establishing a 3D printed artificial human bone sample for biomechanical testing
Creators: name: Wunderlich, Felix
name: Mehler, Dorothea
name: Degner, Katharina
name: Glockner, Christian
name: Rommens, Pol Maria
name: Gruszka, Dominik
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 3D printing
subject: artificial bone sample
subject: biomechanical testing
subject: 610 Medical sciences; Medicine

description: Objectives: Currently used composite bone models (e.g. Sawbones) for biomechanical testing are expensive, do not represent the interindividual anatomical differences and their mechanical characteristics are barely comparable to human bone. We therefore aimed for creating a new 3D printed artificial [for full text, please go to the a.m. URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
Weak decays Xi_Q -> Lambda_Q pi
Creators: name: Voloshin, M. B.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The weak decays Xi_b -> Lambda_b pi and Xi_c -> Lambda_c pi, in which the heavy quark is not destroyed, are discussed. The branching fractions for these decays, corresponding to an absolute rate of order 0.01 ps^{-1}, should be at a one percent level for the b hyperons and at a (few) per mill level for Xi_c, possibly making feasible their experimental study in future. It is shown, through an application of the heavy quark limit, the flavor SU(3) symmetry, and PCAC, that the Delta I = 1/2 rule should hold very well in these decays, and also that the Xi_b decays are purely S wave in the symmetry limit, while the difference between the $S$ wave amplitudes of the Xi_c decays and those for the Xi_b is related, in terms of the heavy quark expansion, to the difference of the total decay rates within the (Xi_c, Lambda_c) triplet of charmed hyperons. We also comment on the amplitudes of the semileptonic transitions Xi_Q -> Lambda_Q l nu and on the weak radiative decays Xi_Q -> Lambda_Q gamma.
description: 8 pages
An extension of the SM based on effective Peccei-Quinn Symmetry
Creators: name: Suematsu, Daijiro
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Peccei-Quinn (PQ) mechanism based on a chiral global U(1) symmetry is considered to be a simple and elegant solution for strong CP problem. Fact that the mechanism could be experimentally examined through the axion search makes it much more interesting and recently it causes a lot of attention again. However, it is also known that the mechanism is annoyed by two serious problems, that is, a domain wall problem and goodness of global symmetry. Any global symmetry is considered not to be exact due to the quantum effect of gravity. In this paper, we consider a solution to these problems, in which quark mass hierarchy and mixing, neutrino mass generation and existence of dark matter are closely related. In our solution, PQ symmetry is assumed to be induced through symmetry breaking at an intermediate scale of a local U(1) symmetry, and a global U(1) symmetry which plays a role of Froggatt-Nielsen symmetry . In the lepton sector, a remnant of the PQ symmetry controls neutrino mass generation and dark matter existence.
description: 25 pages, 2 figures, references added, figures correctly included
Additional file 1 of Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
Creators: name: Gaddey, Pridhvi Krishna
name: Sundararajan, Raja
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology

description: Additional file 1. Supporting data of few validation parameters.
Лизиноприл в лечении больных артериальной гипертензией.docx
Creators: name: Ivanova, Anna
Publisher: name: figshare
Year: 2018
Subjects: Cardiology

description: Несмотря на широкий выбор антигипертензивных препаратов, лишь небольшое число пациентов с артериальной гипертензией (АГ) лечатся эффективно. Ингибиторы ангиотензинпревращающего фермента (АПФ) рассматриваются как препараты первого выбора для стартовой терапии неосложненной АГ Среди множества представителей класса ингибиторов АПФ особого внимания заслуживает лизиноприл, который является одним из наиболее известных и хорошо изученных препаратов этой группы с широким спектром действия и доказанными органопротективными свойствами.
Grand unified textures for neutrino and quark mixings
Creators: name: Berezhiani, Zurab
name: Rossi, Anna
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The atmospheric neutrino data imply large mixing between the $ν_μ$ and $ν_τ$ states, $θ_{23} = (45\pm 12)^\circ$, while the MSW solution to the solar neutrino problem needs very small mixing angle $θ_{12} = (2\pm 1)^\circ$. In the quark sector the situation is rather opposite -- the 23 mixing is tiny, $θ_{23}\simeq 2^\circ$, versus reasonable 12 mixing, $θ_{12}\simeq 13^\circ$. We show that such complementary patterns of the quark and leptonic mixings could naturally emerge in the context of the SU(5) grand unification, assuming that the fermion mass matrices have the Fritzsch-like structures but their off-diagonal entries are not necessarily symmetric. Such a picture exhibits a `see-saw' like correspondence between the quark and leptonic mixing patterns so that the smaller the quark mixing angle is, the larger the corresponding leptonic mixing angle becomes. This fact simply follows from the fermion multiplet structure in SU(5). We also discuss a model with horizontal symmetry U(2) in which the discussed pattern of the mass matrices can arise rather naturally.
description: Latex file, 23 pages, 9 postscript figures. Typos fixed; new figures and references added; some discussions extended and refined
title: Single-center validation of the 2018 ICM criteria for hip and knee PJI
Creators: name: Suero, Eduardo
name: Abdelaziz, Hussein
name: Rademacher, Kristof
name: Gehrke, Thorsten
name: Citak, Mustafa
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: periprosthetic joint infection
subject: total joint arthroplasty
subject: minor criteria
subject: consensus meeting
subject: 610 Medical sciences; Medicine

description: Objectives: The consequences of periprosthetic joint infection (PJI) may be catastrophic in some situations, but an early accurate diagnosis leads to a tremendous improvement in outcome. As clinical symptoms and signs are non-specific in many cases, a diagnosis of PJI can be only established following[for full text, please go to the a.m. URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)
Pulse engineering for population control under dephasing and dissipation
Creators: name: Medina, I.
name: Semião, F. L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We apply reverse-engineering to find electromagnetic pulses that allow for the control of populations in quantum systems under dephasing and thermal noises. In particular, we discuss two-level systems given their importance in the description of several molecular systems as well as quantum computing. Such an investigation naturally finds applications in a multitude of physical situations involving the control of quantum systems. We present an analytical description of the pulse which solves a constrained dynamics where the initial and final populations are fixed a priori. This constrained dynamics is sometimes impossible and we precisely spot the conditions for that. One of our main results is the presentation of analytical conditions for the establishment of steady states for finite coherence in the presence of noise. This might naturally find applications in quantum memories.
description: 5 pages, 6 figures
Клеточный состав лимфоидных узелков стенки трахеи крыс с различной устойчивостью к эмоциональному стрессу.docx
Creators: name: Ivanova, Anna
Publisher: name: figshare
Year: 2018
Subjects: Cell Biology

description: Цель исследования. Выявить закономерности изменения клеточного состава лимфоидных узелков стенки трахеи крыс, устойчивых и неустойчивых к эмоциональному стрессу в условиях моделирования геморрагического инсульта. Материал и методы. Гистологическими методами исследованы лимфоидные образования стенки трахеи 98 крыс-самцов линии Вистар (зона вблизи бифуркации органа). Результаты и заключение. В условиях эксперимента наблюдали значительные изменения клеточного состава лимфоидных узелков, характер которых зависел от стрессоустойчивости животного и срока эксперимента. В то же время активная деструкция клеток в лимфоидных узелках в условиях геморрагического инсульта отмечалась как у устойчивых, так и у предрасположенных к стрессу крыс. Выявленные в условиях экспериментального геморрагического инсульта изменения структуры лимфоидных узелков стенки трахеи свидетельст-вуют о снижении местной иммунной резистентности, что наиболее выражено у неустойчивых к стрессу крыс и может способствовать возникновению такого грозного воспалительного осложнения инсульта, как пневмония.