cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Parameter scaling in the decoherent quantum-classical transition for chaotic systems
Creators: name: Pattanayak, Arjendu K.
name: Sundaram, Bala
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum to classical transition has been shown to depend on a number of parameters. Key among these are a scale length for the action, $\hbar$, a measure of the coupling between a system and its environment, $D$, and, for chaotic systems, the classical Lyapunov exponent, $λ$. We propose computing a measure, reflecting the proximity of quantum and classical evolutions, as a multivariate function of $(\hbar,λ,D)$ and searching for transformations that collapse this hyper-surface into a function of a composite parameter $ζ= \hbar^αλ^βD^γ$. We report results for the quantum Cat Map, showing extremely accurate scaling behavior over a wide range of parameters and suggest that, in general, the technique may be effective in constructing universality classes in this transition.
description: Submitted
Additional file 3 of Examining primary care physician rationale for not following geriatric choosing wisely recommendations
Creators: name: Rowe, Theresa A.
name: Brown, Tiffany
name: Doctor, Jason N.
name: Linder, Jeffrey A.
name: Persell, Stephen D.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3
Lepton flavor-changing Scalar Interactions and Muon $g-2$
Creators: name: Zhou, Y. F.
name: Wu, Y. L.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A systematic investigation on muon anomalous magnetic moment and related lepton flavor-violating process such as $\m\to e\g$, $\t\to e\g$ and $\t\to \m\g$ is made at two loop level in the models with flavor-changing scalar interactions. The two loop diagrams with double scalar exchanges are studied and their contributions are found to be compatible with the ones from Barr-Zee diagram. By comparing with the latest data, the allowed ranges for the relevant Yukawa couplings $Y_{ij}$ in lepton sector are obtained. The results show a hierarchical structure of $Y_{\m e, \t e} \ll Y_{\m \t} \simeq Y_{\m\m}$ in the physical basis if $Δa_μ$ is found to be $>50\times 10^{-11}$. It deviates from the widely used ansatz in which the off diagonal elements are proportional to the square root of the products of related fermion masses. An alternative Yukawa coupling matrix in the lepton sector is suggested to understand the current data. With such a reasonable Yukawa coupling ansatz, the decay rate of $\t\to \m\g$ is found to be near the current experiment upper bound.
description: 15 pages, Revtex, 9 figures, published version in EPJC
Thermal bremsstrahlung probing the nuclear liquid-gas phase transition
Creators: name: Ortega, R.
name: d'Enterria, D.
name: Fernandez, F.
name: Martinez, G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We present the results of the analysis of the hard photon production in the $^{129}${Xe}+$^{\rm nat}${Sn} at 50{\it A} MeV system studied in the GANIL E300 experiment. The energy and angular hard photon distributions confirm the existence of a thermal component which follows the recently measured thermal bremsstrahlung systematics. Exploiting the performances of our complete detection system, consisting of TAPS and 3 charged particle multidetectors, we have also measured the hard photon multiplicity as a function of the charged particle multiplicity.
description: 9 pages, 6 figures, presented at TAPS Workshop VI, Krzyze, Poland, September 2001 (to be published in Acta Phys. Pol.)
Dataset_TGA_ligand_to_core-shell_coated
Creators: name: Pustovalov, Vitaly
name: Sevim, Semih
name: Pané, Salvador
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Nanoparticles

description: The percentage of organic ligand on the surface of nanoparticles TGA_ligand_to_core-shell_coated was determined using a Mettler Toledo TGA/DSC 3 + Star System up to a temperature of 1173 K under steady airflow.
MRI Markers and Functional Performance in Patients With CIS and MS: A Cross-Sectional Study
Creators: name: Rasche, Ludwig
name: Scheel, Michael
name: Otte, Karen
name: Althoff, Patrik
name: Vuuren, Annemieke B. Van
name: Gieß, Rene M.
name: Kuchling, Joseph
name: Bellmann-Strobl, Judith
name: Ruprecht, Klemens
name: Paul, Friedemann
name: Brandt, Alexander U.
name: Schmitz-Hübsch, Tanja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: multiple sclerosis
subject: clinically isolated syndrome
subject: atrophy
subject: thalamus
subject: clinical outcomes
subject: MSFC
subject: functional performance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Brain atrophy is a widely accepted marker of disease severity with association to clinical disability in multiple sclerosis (MS). It is unclear to which extent this association reflects common age effects on both atrophy and function. Objective: To explore how functional performance in gait, upper extremities and cognition is associated with brain atrophy in patients with Clinically Isolated Syndrome (CIS) and relapsing-remitting MS (RRMS), controlling for effects of age and sex. Methods: In 27 patients with CIS, 59 with RRMS (EDSS <= 3) and 63 healthy controls (HC), 3T MRI were analyzed for T2 lesion count (T2C), volume (T2V) and brain volumes [normalized brain volume (NBV), gray matter volume (NGMV), white matter volume (NWMV), thalamic volume (NThaIV)]. Functional performance was measured with short maximum walking speed (SMSW speed), 9-hole peg test (9HPT) and symbol digit modalities test (SDMT). Linear regression models were created for functional variables with stepwise inclusion of age, sex and MR imaging markers. Results: CIS differed from HC only in T2C and T2V. RRMS differed from HC in NBV, NGMV and NThaIV, T2C and T2V, but not in NWMV. A strong association with age was seen in HC, CIS and RRMS groups for NBV (r = -0.5 to -0.6) and NGMV (r = -0.6 to -0.8). Associations with age were seen in HC and RRMS but not CIS for NThaIV (r = -0.3; r = -0.5), T2C (r(s) = 0.3; r(s) = 0.2) and T2V (r(s) = 0.3; r(s) = 0.3). No effect of age was seen on NWMV. Correlations of functional performance with age in RRMS were seen for SMSW speed, 9HPTand SDMT (r = -0.27 to -0.46). Regression analyses yielded significant models only in the RRMS group for 9HPT, SMSW speed and EDSS. These included NBV, NGMV, NThaIV, NWMV, logT2V, age and sex as predictors. NThalV was the only MRI variable predicting a functional measure (9HPT(r)) with a higher standardized beta than age and sex (R2 = 0.36, p < 1e-04). Conclusion: Thalamic atrophy was a stronger predictor of hand function (9HPT) in RRMS, than age and sex. This underlines the clinical relevance of thalamic atrophy and the relevance of hand function as a clinical marker even in mildly disabled patients.
Electrodynamics of magnetoelectric media and magnetoelectric fields
Creators: name: Kamenetskii, E. O.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The relationship between magnetoelectricity and electromagnetism is a subject of a strong interest and numerous discussions in microwave and optical wave physics and material sciences. The definition of the energy and momentum of the electromagnetic (EM) field in a magnetoelectric (ME) medium is not a trivial problem. The question of whether electromagnetism and magnetoelectricity can coexist without an extension of Maxwell theory arises when we study the effects of EM energy propagation and consider group velocity of the waves in a ME medium. The energy balance equation reveals unusual topological structure of fields in ME materials. Together with certain constraints on the constitutive parameters of a medium, definite constraints on the local field structure should be imposed. Analyzing the EM phenomena inside a ME material, we should answer the question: what kind of the near fields arising from a sample of such a material can we measure? Visualization of the ME states requires an experimental technique that is based on an effective coupling to the violation of spatial as well as temporal inversion symmetry. To observe the ME energy in a subwavelength region, it is necessary to assume the existence of first principle near fields, the ME fields. These are non Maxwellian near fields with specific properties of violation of spatial and temporal inversion symmetry. A particular interest to the ME fields arises in studies of metamaterials with artificial atoms ME elements.
Hierarchical organization of modularity in metabolic networks
Creators: name: Ravasz, E.
name: Somera, A. L.
name: Mongru, D. A.
name: Oltvai, Z. N.
name: Barabasi, A. -L.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, their number and degree of clustering following a power law. Within Escherichia coli the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.
Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
Creators: name: Kaminski, Jakob A.
name: Schlagenhauf, Florian
name: Rapp, Michael
name: Awasthi, Swapnil
name: Ruggeri, Barbara
name: Deserno, Lorenz
name: Banaschewski, Tobias
name: Bokde, Arun L. W.
name: Bromberg, Uli
name: Büchel, Christian
name: Quinlan, Erin Burke
name: Desrivières, Sylvane
name: Flor, Herta
name: Frouin, Vincent
name: Garavan, Hugh
name: Gowland, Penny
name: Ittermann, Bernd
name: Martinot, Jean-Luc
name: Martinot, Marie-Laure Paillère
name: Nees, Frauke
name: Orfanos, Dimitri Papadopoulos
name: Paus, Tomáš
name: Poustka, Luise
name: Smolka, Michael N.
name: Fröhner, Juliane H.
name: Walter, Henrik
name: Whelan, Robert
name: Ripke, Stephan
name: Schumann, Gunter
name: Heinz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: genome-wide association
subject: reward anticipation
subject: human intelligence
subject: human brain
subject: stress
subject: metaanalysis
subject: striatum
subject: psychopathology
subject: prediction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.
Universal coacting Poisson Hopf algebras
Creators: name: Agore, A. L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics

description: We introduce the analogue of Manin's universal coacting (bialgebra) Hopf algebra for Poisson algebras. First, for two given Poisson algebras $P$ and $U$, where $U$ is finite dimensional, we construct a Poisson algebra $\mathcal{B}(P,\, U)$ together with a Poisson algebra homomorphism $ψ_{\mathcal{B}(P,\,U)} \colon P \to U \otimes \mathcal{B}(P,\, U)$ satisfying a suitable universal property. $\mathcal{B}(P,\, U)$ is shown to admit a Poisson bialgebra structure for any pair of Poisson algebra homomorphisms subject to certain compatibility conditions. If $P=U$ is a finite dimensional Poisson algebra then $\mathcal{B}(P) = \mathcal{B}(P,\, P)$ admits a unique Poisson bialgebra structure such that $ψ_{\mathcal{B}(P)}$ becomes a Poisson comodule algebra and, moreover, the pair $\bigl(\mathcal{B}(P),\, ψ_{\mathcal{B}(P)}\bigl)$ is the universal coacting bialgebra of $P$. The universal coacting Poisson Hopf algebra $\mathcal{H}(P)$ on $P$ is constructed as the initial object in the category of Poisson comodule algebra structures on $P$ by using the free Poisson Hopf algebra on a Poisson bialgebra (\cite{A1}).
description: To appear in Manuscripta Math. DOI: 10.1007/s00229-020-01207-0
Higher-Derivative Corrections to the Non-Abelian Born-Infeld Action
Creators: name: Bilal, Adel
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We determine higher-derivative terms in the open superstring effective action with U(N) gauge group up to and including order alpha'^4 as can be extracted from 4 boson, 2 boson - 2 fermion and 4 fermion string scattering amplitudes. This yields corrections to the non-abelian Born-Infeld action involving higher derivatives as is relevant for studying D-branes beyond the slowly varying field approximation. While at order alpha'^2 the action has recently been shown to be a symmetrised trace, this no longer is true at order alpha'^3 or alpha'^4. We argue that these terms including higher derivatives are as important in a low-energy expansion as e.g. the much-discussed alpha'^4 F^6 terms. In particular a computation of the fluctuation spectra at order alpha'^4 has to take into account these non-symmetrised trace higher-derivative terms computed here.
description: 26 pages, 2 eps figures, Latex
Objective assessment of a relative afferent pupillary defect by B-mode ultrasound
Creators: name: Schmidt, Felix A.
name: Connolly, Florian
name: Maas, Matthew B.
name: Grittner, Ulrike
name: Harms, Lutz
name: Brandt, Alexander
name: Paul, Friedemann
name: Schreiber, Stephan
name: Ruprecht, Klemens
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: B-mode ultrasound
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: To evaluate B-mode ultrasound as a novel method for objective and quantitative assessment of a relative afferent pupillary defect (RAPD) in a prospective case-control study. Methods: Seventeen patients with unilateral optic neuropathy and a clinically detectable RAPD and 17 age and sex matched healthy controls were examined with B-mode ultrasound using an Esaote-Mylab25 system according to current guidelines for orbital insonation. The swinging flashlight test was performed during ultrasound assessment with a standardized light stimulus using a penlight. Results: B-mode ultrasound RAPD examination was doable in approximately 5 minutes only and was well tolerated by all participants. Compared to the unaffected contralateral eyes, eyes with RAPD showed lower absolute constriction amplitude of the pupillary diameter (mean [SD] 0.8 [0.4] vs. 2.1 [0.4] mm; p = 0.009) and a longer pupillary constriction time after ipsilateral light stimulus (mean [SD] 1240 [180] vs. 710 [200] ms; p= 0.008). In eyes affected by RAPD, visual acuity correlated with the absolute constriction amplitude (r= 0.75, p = 0.001). Conclusions: B-mode ultrasound enables fast, easy and objective quantification of a RAPD and can thus be applied in clinical practice to document a RAPD.
Additional file 1 of Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort
Creators: name: Chalana M. Sol
name: Van Zwol-Janssens, Charissa
name: Philips, Elise M.
name: Asimakopoulos, Alexandros G.
name: Maria-Pilar Martinez-Moral
name: Kurunthachalam Kannan
name: Jaddoe, Vincent W. V.
name: Trasande, Leonardo
name: Santos, Susana
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplemental Material Bisphenols. Tables containing additional subscriptive data and results of sensitivity analysis.
TEKISLIKDA TO'G'RI CHIZIQ TENGLAMALARI VA ULARNI AMALIYOTGA TADBIQI
Creators: name: Abdulhayeva, Gulbahor
name: Mahmudova, Dilnoza
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada tekislikdagi to‘g‘ri chiziq tenglamalari va ularning turli shakllari batafsil ko‘rib chiqiladi. Shuningdek, to‘g‘ri chiziqlarning o‘zaro munosabatlari – parallel, perpendikulyar va kesishish holatlari ham tahlil qilinadi. Mazkur mavzu geometriya va analitik geometriyada keng qo‘llaniladi.
Graft pre-conditioning by peri-operative perfusion of kidney allografts with rabbit anti-human T-lymphocyte globulin results in improved kidney graft function in the early post-transplantation period - a prospective, randomized placebo-controlled trial
Creators: name: Ritschl, Paul V.
name: Günther, Julia
name: Hofhansel, Lena
name: Kühl, Anja A.
name: Sattler, Arne
name: Ernst, Stefanie
name: Friedersdorff, Frank
name: Ebner, Susanne
name: Weiss, Sascha
name: Bösmüller, Claudia
name: Weissenbacher, Annemarie
name: Oberhuber, Rupert
name: Cardini, Benno
name: Öllinger, Robert
name: Schneeberger, Stefan
name: Biebl, Matthias
name: Denecke, Christian
name: Margreiter, Christian
name: Resch, Thomas
name: Aigner, Felix
name: Maglione, Manuel
name: Pratschke, Johann
name: Kotsch, Katja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: kidney transplantation
subject: organ preservation
subject: ATLG
subject: ischemia reperfusion injury
subject: RCT
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Although prone to a higher degree of ischemia reperfusion injury (IRI), the use of extended criteria donor (ECD) organs has become reality in transplantation. We therefore postulated that peri-operative perfusion of renal transplants with anti-human T-lymphocyte globulin (ATLG) ameliorates IRI and results in improved graft function. Methods: We performed a randomized, single-blinded, placebo-controlled trial involving 50 kidneys (KTx). Prior to implantation organs were perfused and incubated with ATLG (AP) (n = 24 kidney). Control organs (CP) were perfused with saline only (n = 26 kidney). Primary endpoint was defined as graft function reflected by serum creatinine at day 7 post transplantation (post-tx). Results: AP-KTx recipients illustrated significantly better graft function at day 7 post-tx as reflected by lower creatinine levels, whereas no treatment effect was observed after 12 months surveillance. During the early hospitalization phase, 16 of the 26 CP-KTx patients required dialysis during the first 7 days post-tx, whereas only 10 of the 24 AP-KTx patients underwent dialysis. No treatment-specific differences were detected for various lymphocytes subsets in the peripheral blood of patients. Additionally, mRNA analysis of 0-h biopsies post incubation with ATLG revealed no changes of intragraft inflammatory expression patterns between AP and CP organs. Conclusion: We here present the first clinical study on peri-operative organ perfusion with ATLG illustrating improved graft function in the early period post kidney transplantation.
Cost analysis of early discharge using combined copeptin/cardiac troponin testing versus serial cardiac troponin testing in patients with suspected acute coronary syndrome
Creators: name: Reinhold, Thomas
name: Giannitsis, Evangelos
name: Möckel, Martin
name: Frankenstein, Lutz
name: Vafaie, Mehrshad
name: Vollert, Jörn O.
name: Slagman, Anna
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: acute coronary syndrome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Symptoms indicating acute coronary syndrome are commonly seen in emergency rooms, but only 10% of patients are actually diagnosed with acute myocardial infarction (AMI). The Guidelines for the diagnosis of patients with suspected AMI include either multiple testing of cardiac troponin (cTN) or a single combined test of cTN and copeptin, which facilitates earlier diagnosis or exclusion of AMI. The aim of the present analysis was to investigate the impact of combined copeptin/cTN testing on health care resource consumption and related costs both during and after initial hospital treatment. Methods and results: The analysis was based on the BIC-8 trial and financial data of participating study sites. A cost analysis was carried out primarily from the hospital perspective and secondarily from the perspective of German statutory health insurers. The underlying assumptions of the investigation were tested for robustness in additional sensitivity analyses. In total, the data of 713 patients (n = 359 combined copeptin/cTN testing, n = 354 serial cTN testing) were evaluated. From a hospital perspective, the combined copeptin/cTN testing showed a reduced number of medical procedures and a lower frequency of inpatient admissions. The average staff time was significantly reduced by a mean of 49 minutes (95% confidence interval (CI) 46 to 53) per patient, accompanied by a significant mean reduction of 131 minutes (95%Cl 104 to 158) in the time patients stayed in the emergency room. The initial hospital treatment was less cost-intensive. Over the entire study period, no significant cost differences were observed between the groups for health insurance. Conclusion: The combined copeptin/cTN testing has the potential to save costs and staff time in acute care and for the entire hospital stay. The primary explanations for these findings are early identification and ruling out patients without AMI along with the associated reduced need for acute medical treatment.
Charged Higgs searches in the Georgi-Machacek model at the LHC
Creators: name: Ghosh, Nivedita
name: Ghosh, Swagata
name: Saha, Ipsita
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Georgi-Machacek Model allows for a large triplet vacuum expectation value (vev) with a custodial symmetric scalar potential. This manifestly leads to large charged Higgs coupling to SM fermions thus enhancing the detection probability of the model at the Large hadron collider. We show that the latest bound from LHC searches on singly charged Higgs scalar decaying to top and bottom quark restricts the triplet vev from above. We demonstrate that the combined limit from theoretical constraints and the latest Higgs data together with this charged Higgs bound can already curb the model parameter space significantly. Further, we propose the charged Higgs decaying to $W^{\pm}$ boson and a SM-like Higgs as a prospective channel to probe the yet unbounded model parameter space at the future run of the LHC. A simple cut-based analysis for this channel has been made showing the parameter region that can be probed with $5σ$ significance at the high luminosity LHC run.
description: 14 pages, 7 figures, 2 tables. Figures 1, 2 and 7 have been modified, abstract updated, references updated, version accepted for publication in Phys. Rev. D
Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry
Creators: name: Klein, Oliver
name: Strohschein, Kristin
name: Nebrich, Grit
name: Fuchs, Michael
name: Thiele, Herbert
name: Giavalisco, Patrick
name: Duda, Georg N.
name: Winkler, Tobias
name: Kobarg, Jan Hendrik
name: Trede, Dennis
name: Geissler, Sven
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: MALDI imaging mass spectrometry
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Pre-clinical and clinical studies are now beginning to demonstrate the high potential of cell therapies in enhancing muscle regeneration. We previously demonstrated functional benefit after the transplantation of autologous bone marrow mesenchymal stromal cells (MSC-TX) into a severe muscle crush trauma model. Despite our increasing understanding of the molecular and cellular mechanisms underlying MSC's regenerative function, little is known about the local molecular alterations and their spatial distribution within the tissue after MSC-TX. Here, we used MALDI imaging mass spectrometry (MALDI-IMS) in combination with multivariate statistical strategies to uncover previously unknown peptide alterations within severely injured skeletal muscles. Our analysis revealed that very early molecular alterations in response to MSC-TX occur largely in the region adjacent to the trauma and only to a small extent in the actual trauma region. Using "bottom up" mass spectrometry, we subsequently identified the proteins corresponding to the differentially expressed peptide intensity distributions in the specific muscle regions and used immunohistochemistry to validate our results. These findings extend our current understanding about the early molecular processes of muscle healing and highlights the critical role of trauma adjacent tissue during the early therapeutic response upon treatment with MSC.
Important shapeshifter: mechanisms allowing astrocytes to respond to the changing nervous system during development, injury and disease
Creators: name: Schiweck, Juliane
name: Eickholt, Britta J.
name: Murk, Kai
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: astrocytes
subject: morphology
subject: CNS
subject: pathology
subject: cytoskeleton
subject: astrogliosis
subject: brain trauma
subject: synapse
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Astrocytes are the most prevalent glial cells in the brain. Historically considered as "merely supporting" neurons, recent research has shown that astrocytes actively participate in a large variety of central nervous system (CNS) functions including synaptogenesis, neuronal transmission and synaptic plasticity. During disease and injury, astrocytes efficiently protect neurons by various means, notably by sealing them off from neurotoxic factors and repairing the blood-brain barrier. Their ramified morphology allows them to perform diverse tasks by interacting with synapses, blood vessels and other glial cells. In this review article, we provide an overview of how astrocytes acquire their complex morphology during development. We then move from the developing to the mature brain, and review current research on perisynaptic astrocytic processes, with a particular focus on how astrocytes engage synapses and modulate their formation and activity. Comprehensive changes have been reported in astrocyte cell shape in many CNS pathologies. Factors influencing these morphological changes are summarized in the context of brain pathologies, such as traumatic injury and degenerative conditions. We provide insight into the molecular, cellular and cytoskeletal machinery behind these shape changes which drive the dynamic remodeling in astrocyte morphology during injury and the development of pathologies.
Multi-cover skeins, quivers, and 3d $\mathcal{N}=2$ dualities
Creators: name: Ekholm, Tobias
name: Kucharski, Piotr
name: Longhi, Pietro
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Geometric Topology (math.GT)
subject: Symplectic Geometry (math.SG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The relation between open topological strings and representation theory of symmetric quivers is explored beyond the original setting of the knot-quiver correspondence. Multiple cover generalizations of the skein relation for boundaries of holomorphic disks on a Lagrangian brane are observed to generate dual quiver descriptions of the geometry. Embedding into M-theory, a large class of dualities of 3d $\mathcal{N}=2$ theories associated to quivers is obtained. The multi-cover skein relation admits a compact formulation in terms of quantum torus algebras associated to the quiver and in this language the relations are similar to wall-crossing identities of Kontsevich and Soibelman.
description: 43+5 pages
Additional file 1 of Glass-bottled drinking water: a time capsule to study the historic presence of hazardous chemicals using effect-based methods
Creators: name: Lundqvist, Johan
name: Persson, Kenneth M.
name: Oskarsson, Agneta
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Additional file 1 : Additional text, figures and tables.
Gauge-Invariant Perturbations of Varying-Alpha Cosmologies
Creators: name: Barrow, John D.
name: Mota, D. F.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Using a gauge-invariant formalism we derive and solve the perturbed cosmological equations for the BSBM theory of varying fine structure 'constant'. We calculate the time evolution of inhomogeneous perturbations of the fine structure constant, $\frac{δα}α$ on small and large scales with respect to the Hubble radius. In a radiation-dominated universe small inhomogeneities in $α$ will decrease on large scales but on scales smaller than the Hubble radius they will undergo stable oscillations. In a dust-dominated universe small inhomogeneous perturbations in $α$ will become constant on large scales and on small scales they will increase as $t^{2/3}$, and $\frac{δα}α$ will track $% \frac{δρ_{m}}{ρ_{m}}$ . If the expansion accelerates, as in the case of a $Λ$ or quintessence-dominated phase, inhomogeneities in $α$ will decrease on both large and small scales. The amplitude of perturbations in $α$ will be much smaller than that of matter or radiation perturbations. We also present a numerical study of the non-linear evolution of spherical inhomogeneities in radiation and dust universes by means of a comparison between the evolution of flat and closed Friedmann models with time-varying $α.$Various limitations of these simple models are also discussed.
description: 28 pages, 4 figures, 1 table added, some results changed, references added, typos were corrected
The Passive Use Value of the Mediterranean Forest
Creators: name: Otrachshenkoy, Vladimir
name: Otrachshenkoy, Vladimir
Publisher: name: Unknown
Year: 2014
Subjects: subject: Environmental Economics and Policy
subject: Forest
subject: Mediterranean Region
subject: Passive Use
subject: Welfare Loss

description: In this study we estimate the passive use value of forest in different ecological zones in the Mediterranean region. We estimate these values for forests using meta-analysis. These estimates are used to reveal the annual monetary values per hectare for each country. The total annual amount of passive use value of the Mediterranean forest is about one billion international dollars. The estimated passive use value of the forest from this study can be used to account for the social welfare loss caused by fire, insects, diseases, biotic agents, and abiotic factors.
Additional file 2 of Communication about diagnosis, prognosis, and prevention in the memory clinic: perspectives of European memory clinic professionals
Creators: name: Hendriksen, Heleen M. A.
name: van Gils, Aniek M.
name: van Harten, Argonde C.
name: Hartmann, Tobias
name: Mangialasche, Francesca
name: Kamondi, Anita
name: Kivipelto, Miia
name: Rhodius-Meester, Hanneke F. M.
name: Smets, Ellen M. A.
name: van der Flier, Wiesje M.
name: Visser, Leonie N. C.
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Hematology

description: Additional file 2: Supplementary Table 1. Patient cases: communicating about diagnosis and diagnostic tests. Supplementary Table 2. Patient cases: communicating about prognosis and prevention.
Additional file 1 of Mental health and wellbeing implications of the COVID-19 quarantine for disabled and disadvantaged children and young people: evidence from a cross-cultural study in Zambia and Sierra Leone
Creators: name: Sharpe, Darren
name: Rajabi, Mohsen
name: Chileshe, Clement
name: Sitali Mayamba Joseph
name: Sesay, Ibrahim
name: Williams, James
name: Siraj Sait
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Copy of the Kick Out COVID-19 survey.
Large Solar Neutrino Mixing and Radiative Neutrino Mechanism
Creators: name: Kitabayashi, Teruyuki
name: Yasue, Masaki
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We find that the presence of a global $L_e-L_μ-L_τ$ ($\equiv L^\prime$) symmetry and an $S_2$ permutation symmetry for the $μ$- and $τ$-families supplemented by a discrete $Z_4$ symmetry naturally leads to almost maximal atmospheric neutrino mixing and large solar neutrino mixing, which arise, respectively, from type II seesaw mechanism initiated by an $S_2$-symmetric triplet Higgs scalar $s$ with $L^\prime=2$ and from radiative mechanism of the Zee type initiated by two singly charged scalars, an $S_2$-symmetric $h^+$ with $L^\prime=0$ and an $S_2$-antisymmetric $h^{\prime +}$ with $L^\prime=2$. The almost maximal mixing for atmospheric neutrinos is explained by the appearance of the democratic coupling of $s$ to neutrinos ensured by $S_2$ and $Z_4$ while the large mixing for solar neutrinos is explained by the similarity of $h^+$- and $h^{\prime +}$-couplings described by $f^h_+\sim f^h_-$ and $μ_+\simμ_-$, where $f^h_+$ ($f^h_-$) and $μ_+$ ($μ_-$) stand for $h^+$ ($h^{\prime +}$)-couplings, respectively, to leptons and to Higgs scalars.
description: RevTex, 10 pages including one figure. In Ref.[25], the cited page number is corrected
Orthopedic implant-associated infections caused by Cutibacterium spp. - A remaining diagnostic challenge
Creators: name: Renz, Nora
name: Mudrovcic, Stasa
name: Perka, Carsten
name: Trampuz, Andrej
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: implant-associated infection (IAI)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The definition criteria and clinical characteristics of implant-associated infection (IAI) caused by Cutibacterium (formerly Propionibacterium) spp. are poorly known. We analyzed microbiologically proven Cutibacterium orthopedic IAI in a prospective cohort. Methods: Patients with periprosthetic joint infections (PJI) and fixation device-associated infections (FDAI) caused by Cutibacterium spp. were prospectively included. IAI was defined by significant growth of Cutibacterium spp. and presence of at least one non-microbiological criterion for infection. The McNemar's chi-squared or binomial test was used to compare the performance of diagnostic tests. Results: Of 121 patients with Cutibacterium IAI, 62 patients (51%) had PJI and 59 (49%) had FDAI. 109 infections (90%) were caused by C. acnes and 12 (10%) by C. avidum. The median time from implantation until diagnosis of infection was 15.7 months (interquartile range, 5-46.5 months). Clinical local signs were present in 30 patients (28%) and radiological implant loosening in 64 patients (63%). Culture sensitivity of sonication fluid was 84%, of peri-implant tissue 84% and of synovial or peri-implant fluid 56% after 14 days of incubation. Conclusion: Cutibacterium IAI was diagnosed late in the disease course and presented with subtle signs. Prolonged culture incubation and implant sonication improved the poor performance of conventional microbiological tests. Due to lack of reliable diagnostic tests, Cutibacterium remains difficult to detect making the diagnosis challenging.
Towards a Structural Framework for Explicit Domain Knowledge in Visual Analytics
Creators: name: Rind, Alexander
name: Wagner, Markus
name: Aigner, Wolfgang
Publisher: name: arXiv
Year: 2019
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: H.5.m; J.3; I.3.6

description: Clinicians and other analysts working with healthcare data are in need for better support to cope with large and complex data. While an increasing number of visual analytics environments integrates explicit domain knowledge as a means to deliver a precise representation of the available data, theoretical work so far has focused on the role of knowledge in the visual analytics process. There has been little discussion about how such explicit domain knowledge can be structured in a generalized framework. This paper collects desiderata for such a structural framework, proposes how to address these desiderata based on the model of linked data, and demonstrates the applicability in a visual analytics environment for physiotherapy.
description: 8 pages, 5 figures
On "the authentic damping mechanism" of the phonon damping model
Creators: name: Ponomarev, V. Yu.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Some general features of the phonon damping model are presented. It is concluded that the fits performed within this model have no physical content.
Density-functional theory for the Hubbard model: numerical results for the Luttinger liquid and the Mott insulator
Creators: name: Capelle, K.
name: Lima, N. A.
name: Silva, M. F.
name: Oliveira, L. N.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We construct and apply an exchange-correlation functional for the one-dimensional Hubbard model. This functional has built into it the Luttinger-liquid and Mott-insulator correlations, present in the Hubbard model, in the same way in which the usual {\it ab initio} local-density approximation (LDA) has built into it the Fermi-liquid correlations present in the electron gas. An accurate expression for the exchange-correlation energy of the homogeneous Hubbard model, based on the Bethe Ansatz (BA), is given and the resulting LDA functional is applied to a variety of inhomogeneous Hubbard models. These include finite-size Hubbard chains and rings, various types of impurities in the Hubbard model, spin-density waves, and Mott insulators. For small systems, for which numerically exact diagonalization is feasible, we compare the results obtained from our BA-LDA with the exact ones, finding very satisfactory agreement. In the opposite limit, large and complex systems, the BA-LDA allows to investigate systems and parameter regimes that are inaccessible by traditional methods.
Short- and long-term renal outcome of hemolytic-uremic syndrome in childhood
Creators: name: Vaterodt, Laura
name: Holle, Johannes
name: Hüseman, Dieter
name: Müller, Dominik
name: Thumfart, Julia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: hemolytic uremic syndrome
subject: children
subject: renal sequelae
subject: EHEC
subject: Shigatoxin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Hemolytic-uremic syndrome (HUS) is a common cause for intrarenal acute kidney injury in childhood. More than 90% of HUS cases are associated with an infection by Shigatoxin-producing Escherichia coli (STEC) whereas the reminder comprises a heterogeneous group (here classified as Non-STEC-HUS). Renal impairment can persist in patients with HUS. This study presents data from four decades investigating the short- and long-term outcome of HUS in childhood. Materials and Methods: In a retrospective single-center-study clinical and laboratory data of the acute phase and of 1- to 10-year follow-up visits of children with HUS were analyzed. Results: 92 HUS-patients were identified from 1996 to 2014 (STEC-HUS-group: n = 76; Non-STEC-HUS-group: n = 16) and 220 HUS-patients between 1976 and 1995. STEC-HUS was increasingly caused by Non-O157 strains and mortality rate declined over the past decades (1.3 vs 9.5%). Renal sequelae persisted more often in the group 1976-1995 (39.3%) than in the group 1996-2014 (28.3%), but more than 50% of all patients were lost to follow-up. Conclusion: Although renal outcome has improved over the investigated last decades, patients with HUS still face a high risk of permanent renal damage. These findings underline the importance of a consequent long-term follow-up in HUS-patients.
OPE between the energy-momentum tensor and the Wilson loop in N=4 Super-Yang-Mills theory
Creators: name: Azuma, Takehiro
name: Kawai, Hikaru
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the operator product expansion T_{μν}(z) W[C] in N=4 4-dimensional Super-Yang-Mills (SYM) theory with U(N) gauge group, and clarify that the closed Wilson loop does not possess an anomalous dimension and that only the shape of the loop is changed by the conformal transformation.
description: 38 pages, 7 figures.(v3) translated into the PTP format (v4) some subtleties corrected
Discrete quantum gravity: applications to cosmology
Creators: name: Gambini, Rodolfo
name: Pullin, Jorge
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the application of the consistent lattice quantum gravity approach we introduced recently to the situation of a Friedmann cosmology and also to Bianchi cosmological models. This allows us to work out in detail the computations involved in the determination of the Lagrange multipliers that impose consistency, and the implications of this determination. It also allows us to study the removal of the Big Bang singularity. Different discretizations can be achieved depending on the version of the classical theory chosen as a starting point and their relationships studied. We analyze in some detail how the continuum limit arises in various models. In particular we notice how remnants of the symmetries of the continuum theory are embodied in constants of the motion of the consistent discrete theory. The unconstrained nature of the discrete theory allows the consistent introduction of a relational time in quantum cosmology, free from the usual conceptual problems.
description: 19 pages, RevTex, 9 figures
Phenomenology From Lattice QCD
Creators: name: Sachrajda, C T
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I review two subjects in which lattice simulations are making, or can make in the future, a significant contribution to particle physics phenomenology. The first subject is the evaluation of quantities which enter into the determination of the vertex $A$ of the unitarity triangle from experimental measurements of decay rates and mixing amplitudes. These quantities include the form-factors for semileptonic B-decays, the leptonic decay constants of the $B$ and $B_s$ mesons and the $B$-parameters for $B_{d}$-$\bar B_{d}$ and $B_{s}$-$\bar B_{s}$ mixing and the corresponding parameter for $K$-$\bar K$ mixing, $B_K$. In the second part of this talk I will review the status and prospects for the evaluation of $K\toππ$ amplitudes and for the subsequent study of the $ΔI=1/2$ rule and the evaluation of $ε^\prime/ε$.
description: 14 Pages, 11 Figues, Invited talk presented at the 20th International Symposium on Lepton and Photon Interactions at High Energies, Rome, Italy, July 23rd - 28th 2001