cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer’s disease
Creators: name: Liang, Guocui
name: Gao, Chengxia
name: Zhang, Liwei
name: Du, Huizhi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Neuroscience
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Tenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active ingredients of Forsythia suspensa (Thunb.) Vahl. (a species in the genus Forsythia, family Meliaceae). The studies have shown that tenuigenin-based Polygala tenuifolia Willd. extract (YZ) and FA have protective effects on nervous damage. In the study the combination (YF) of YZ and FA showed synergistic neuro-protective effects on PC12 cell model of Alzheimer’s disease (AD). YF (2:1) which was made up of 2/3 YZ and 1/3 FA increased cell viability, inhibited AChE expression and activity, alleviated apoptosis and slowed Aβ aggregation, while YF (1:2) which consisted of 1/3 YZ and 2/3 FA depressed inflammation and oxidative stress. There was no obvious synergistic effect of YF on Tau phosphorylation.
Religion in the United States Syllabus
Creators: name: Crow, John L.
Publisher: name: figshare
Year: 2016
Subjects: History
Religious Studies

description: Religions of the United States. This course will survey the history of various religious traditions that have been practiced in North America and the Caribbean over the last five+ centuries. This course will also look at the unique issues encountered when studying the history of religion in an academic environment. The issues of definition, insider/outsider viewpoints, and colonial legacies will just be a few of the topics explored while surveying the religious practices and beliefs that can be found in North America. Because this course meets the liberal studies writing requirement, you will be assigned to write essays accumulating to at least 3000 words over the semester. These essays will help you delve deeper into the materials we cover and assist you in your writing and critical thinking skills. Lastly, while there is a course text book, it is a collection of primary materials. This book and additional primary materials will be assigned weekly. Reading Primary materials will help further develop your critical thinking skills as you will have to apply what the texts say to each day’s lesson and discussion.
Economic supply chain modelling of industrial insect production in The Netherlands
Creators: name: Leipertz, M.
name: Hogeveen, H.
name: Saatkamp, H.W.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: Defatted larvae meal (dLM), specifically from black soldier flies, could help overcome the animal protein gap. As insect production is an emerging sector, current economic research is scarce and very diverse. Thus, the aim of this research was to develop a simulation model that enables the analysis of full industrial scale costs of producing dLM and to provide insight in the distribution of these costs in the insect supply chain. The deterministic supply chain model is built on three modules, technical, transition and economic module, which all follow a previously defined supply chain structure and allow to extract quantity and price information for intermediate or final products. The model was parameterized and checked for plausibility in multiple consultation rounds with the INSECTFEED consortium and business partners. Additionally, model behaviour was checked with scenario, sensitivity, and break-even price analyses. In the default situation 5.57 tDM raw substrate and 26.7 million neonates are required to produce 1 tDM dLM for a price of €5,116 tDM. Most costs are added in the raw substrate delivery (€1,952 tDM) and production and collection (€821 tDM) step. Important cost factors are the raw substrate (€1,939 tDM) and building and inventory (€1,459/tDM). Parameters with high relative response rate towards the price of dLM are the feed conversion rate, dry matter percentage of larvae, raw substrate price, larvae density, labour wage and growth rate. To reach break-even prices for substituting fish meal with alive grown larvae (AGL) (€1,318 tDM AGL), improving production parameters is not sufficient. Just changing prices of raw substrate to -€78 tDM or frass to €1,175 tDM would enable a profitable operation. However, these are not deemed as realistic in mass production. Although there is some insecurity in data, the model results are the most realistic representation of industrial scale production amounts and costs.
New Religious Movements Course Syllabus
Creators: name: Crow, John L.
Publisher: name: figshare
Year: 2016
Subjects: History
Religious Studies

description: This course is designed to look at a variety of religious traditions that have emerged in the United States over the last two centuries. Over the duration of the course we will examine these religious traditions, their history, context, and reception by society in general. The field of study called New Religious Movements (NRMs) has a history of its own, one intimately tied to the traditions its studies. The course will examine this history looking at its origins in “cult studies” of the 1970s. Thus to study New Religious Movements in America, it is also necessary to review where the field of study derived and how that history shapes how which traditions are included in its domain and which are excluded. As such, the course is based on a number of broad questions regarding New Religious Movements and their study: What is a New Religious Movement (NRM)? Is it a cult? How do NRMs differ from other religious movements or institutions? How are they similar? How do members of NRMs understand their own history and the history of the world? What is their worldview? How do NRMs change over time? Do they become more conventional or more oppositional? When did the study of NRMs begin and why? What is the history of the academic field of New Religious Studies? What is the value in studying NRMs, their history, and the way the Academy has responded to them? The course will end with an extended study of Scientology.
title: OFROM: interview avec unifr16a09m
Creators: name: Delafontaine, François
name: Morel, Mathilde
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.fd3edc7p.v2#24a1c16525e4c8870c35f7609723d12cab659edd
Supplementary document for Compatible camouflage for dual-band guided-laser radar and infrared via a metamaterial perfect absorber - 6874225.pdf
Creators: name: Luo, Mingyu
name: Xie, Tong
name: Li, Xin
name: Du, Te
name: Zhenrong, Zhang
name: Yang, Junbo
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary S1: The influence of the proposed device at different crystallization fractions of GST
Supplementary document for Compatible camouflage for dual-band guided-laser radar and infrared via a metamaterial perfect absorber - 6815145.pdf
Creators: name: Luo, Mingyu
name: Xie, Tong
name: Li, Xin
name: Du, Te
name: Zhenrong, Zhang
name: Yang, Junbo
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary S1: The influence of the proposed device at different crystallization fractions of GST
Introduction to Buddhism Syllabus
Creators: name: Crow, John L.
Publisher: name: figshare
Year: 2016
Subjects: History
Religious Studies

description: Introduction to Buddhism. This class will explore and engage the history, beliefs, and practices of Buddhism since its beginning over 2,500 years ago. Students will have an opportunity to survey the various ways Buddhism has manifested in different parts of the word during diverse time periods. It will cover all major forms of Buddhism, including Theravada, Mahayana, and Vajrayana Buddhism, important historical, philosophical, and doctrinal developments of Buddhism, as well as how Buddhism was received in “the west,” meaning Europe and the Americas. The course will also challenge students to develop analytical and critical think skills. This will also allow students the opportunity to compare Buddhism to other religious traditions with which they may be familiar, and be applied to any other subject that they wish to analyze.
Archaeological Projects in Cumbria 2010
Creators: name: Anon,
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 253-284
description: Brief notes of archaeological investigations carried out in Cumbria during 2010, arranged in alphabetical order by town or parish, with a separate section covering the Lake District National Park.
A facile, regio and diastereoselective synthesis of functionalized azetidin-2-ones: Cu(I) mediated Kinugasa reaction of functionalized nitrones with acetylenic alcohols
Creators: name: Sharma, Priyanka
name: Mahajan, Dinesh
name: Kumar, Vipan
name: Kumar, Rupesh
name: Bhargava, Gaurav
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Mental Health

description: The manuscript presents an efficient method for the synthesis of various cis-azetidin-2-ones with high regio- and diastereoselectivity. This approach utilizes Kinugasa reaction involving diverse functionalized nitrones, including diaryl nitrones and α,β-unsaturated nitrones, in conjunction with acetylenic alcohols. Copper (I) serves as a catalyst to facilitate the transformation.
Tree-ring Dating of Buildings on the Solway Plain.
Creators: name: Jennings, Nina
name: Messenger, Peter
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 247-247
description: Note on buildings sampled for dating by the Nottingham Dendrochronology Laboratory with the aid of a grant from English Heritage. Dates in the 15th to 17th centuries are given for timbers from eight structures. Part of the grant was also used to fund training, as well as the copying of the 1910 Land Tax Records for the Solway Plain, which were deposited at the Carlisle County Record Office. LD
Sulfonamide tethered 1,4-disubstituted 1,2,3-triazoles: Synthesis and antibacterial evaluation
Creators: name: Yadav, Jyoti
name: Kaushik, C. P.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A series of twenty one sulfonamide tethered 1,4-disubstituted 1,2,3-triazoles was synthesized in good yields through a facile expeditious click synthetic protocol involving Cu(I) mediated cyclization between terminal alkynes containing ester linkage and 4-azidobenzenesulfonamide. All the synthesized triazoles were characterized using FTIR,1H NMR,13C NMR and HRMS techniques. Synthesized compounds were also evaluated for in vitro antibacterial activity against two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram negative bacteria (Klebsiella pneumoniae, Escherichia coli) by serial dilution method. In the series, compound 6 l, 3-(1-(4-sulfamoylphenyl)-1H-1,2,3-triazol-4-yl)propyl 4-bromobenzoate with Minimum Inhibitory Concentration (MIC) 0.0134 µmol/mL exhibited appreciable antibacterial activity against all bacterial strains comparable with standard drug Ciprofloxacin (MIC 0.0189 µmol/mL). Further, molecular docking study was also performed to gain insight for binding interactions with dihydropteroate synthase enzyme.
title: OFROM: interview avec unifr16a08m
Creators: name: Delafontaine, François
name: Moos, David
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.7a79r69k.v2#6af02f2d04ece172abc973bc2d5643dcc2046159
Religion & Science: Examining a Complex History of Interaction Syllabus
Creators: name: Crow, John L.
Publisher: name: figshare
Year: 2016
Subjects: History
Religious Studies

description: Religion & Science: Examining a Complex History of Interaction. This course is a historical study of the relationship between religion and science. It examines the history of the domains religion and science by surveying the historical uses and understanding of the categories religion and science. The survey begins in the ancient period (3500 BCE to 500 CE), by looking broadly at the construction of the modern categories of religion and science and how they have been projected backwards onto the domain of natural philosophy. Moving forward forward trough the medieval period (500 CE to 1500 CE), it then spends a few weeks in the early modern period (1500 CE to 1750 CE) with a tight focus on the changing nature of natural philosophy as it was understood and practiced by a few select historical figures including Francis Bacon, Galileo Galilei, Thomas Tymme, Robert Boyle, and Isaac Newton. It also notes the emergence of the category of religion deriving from significant changes within Europe during the early modern period, particularly the Protestant Reformation. Finally, the last third of the course looks at the modern period (1715 CE to present) and the emergence of science in the late eighteenth / early nineteenth centuries, and how it became the primary way of knowing the world, displacing the previous ways of knowing which included Christianity. While this course is intended to increase awareness of the history of these categories of knowledge, another goal of this course is to improve your critical thinking skills. Both will be accomplished through the readings, lecture videos, and assignments, which will challenge students to think broadly, creatively, and to look for answers below the surface, and to think about implications and the causes and effects of historical unfolding.
An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst
Creators: name: Sekhar, V. N. Chandra
name: Simhachalam, Gorle
name: Rao, L. Vaikunta
name: Rao, A. V. Dhanunjaya
name: Shankar, Madhavaram
name: Raghunadh, Akula
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO2 as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO2 has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.
Design, synthesis, and molecular docking study of N-(arylsulfonyl)-l-proline-piperazine hybrids tethered with pyrazole/benzofuran moiety as antimicrobial agents
Creators: name: Kilbile, Jaydeo T.
name: Ansari, Siddique Akber
name: Gadekar, Suchita S.
name: Krishna, Vagolu S.
name: Damale, Manoj G.
name: Kashid, Bharat B.
name: Sangshetti, Jaiprakash N.
name: Sapkal, Suryakant B.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In search of novel antimicrobial agents, new series of N-(arylsulfonyl)-l-proline-derived hybrids tethered with pharmacologically attractive cores as 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine and 5-(Piperazin-1-yl)benzofuran-2-carboxamide were synthesized and evaluated for in vitro antimicrobial potential against six different representative human pathogenic strains. Among all, N-acetyl derivative 5e containing phenylpyrazolyl moiety displayed an appreciable inhibitory value (MIC: 107 µg/mL) with noteworthy binding energy (–6.65 kcal/mol) against S. aureus as compared to standard ampicillin (MIC: 250 µg/mL). The N-phenyl-pyrazolyl containing analogue 5b elicited comparable activity against E. coli and P. aeruginosa with MIC values of 104 µg/mL and 121 µg/mL, respectively. Moreover, 5b, 5d, and 6c showed appreciable antioxidant activity (IC50:19.25–20.69 µg/mL) as compared to butylated hydroxytoluene (BHT, IC50:16.47 μg/mL). Molecular docking studies against target tyrosyl-tRNA synthetase (TyrRS) of S. aureus (PDB: 1JIJ) revealed the potential binding mode of the ligands to the appropriate site of targets and their plausible mechanism of in vitro antibacterial activity.
title: OFROM: interview avec unifr16a07m
Creators: name: Delafontaine, François
name: Conti, Inès
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.dcd7j8s9.v2#2342f3cb0e64817f642ffe00061e51176f3aecc9
MAKTABGACHA KATTA YOSHDAGI BOLALARNI KREATIV KOMPETENSIYASINI RIVOJLANTIRISH USULLARI VA METODIKASI
Creators: name: Toshpo'latova, Inobat
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada maktabgacha yoshdagi bolalarni innovatsion pedagogik texnologiyalar yordamida kreativ fikrlashga o’rgatishga doir zaruriy ma’lumotlar keltirilgan. Shuningdek maqolada kreativlik, innovatsion texnologiya, maktabgacha ta’lim, maktab Yoshi kabi tushunchalar mazmuni ham yoritilgan.
New draft item
Creators: name: Sundiman, Didi
Publisher: name: figshare
Year: 2016
Subjects: subject: 150301 Business Information Management (incl. Records, Knowledge and Information Management, and Intelligence)
subject: FOS: Economics and business
subject: 150311 Organisational Behaviour
subject: 150310 Organisation and Management Theory
subject: 150314 Small Business Management

description: This study aimed to get empirical evidence about knowledge
management (KM) practices that play a role in creating an
excellence service through the support of the leader, employee
training or learning opportunities and the sharing of knowledge, so
as to improve the performance of employees in providing services
to consumers.
title: OFROM: interview avec unifr16a06m
Creators: name: Delafontaine, François
name: Colombara, Baptiste
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a906w1ao.v2#b7d5db0dca423ae75a6745be7dc1b632dd5a3689
Design, synthesis and antibacterial assessment of novel 4H-chromene analogues
Creators: name: Shaban, Safaa S. M.
name: Haneen, David S. A.
name: Abou-El-Regal, Mohsen M.
name: El-Metwally, Souad A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives 2–15 were synthesized, and their antibacterial effectiveness was studied. The reaction of the 2-amino-4H-chromene derivative 1 with a variety of reagents such as acetic anhydride, formic acid, chloroacetyl chloride, cyclopentanone, ethyl acetoacetate, diethyl malonate, aldehydes, and isatin produced derivatives 2–13. Compound 1 was also treated with aromatic amines such as p-toluidine and/or benzene-1,4-diamine with formaldehyde, yielding derivatives 14 and 15, respectively; spectral techniques were used to confirm the predicted structures of all compounds. The antibacterial activity of the recently synthesized compounds was assessed against two types of bacteria, Bacillus subtilis and Escherichia coli. There is encouraging antibacterial activity in compounds 5 and 7.
Results of an Archaeological Watching Brief to the Rear of 3 Castle Street, Kendal and a Consideration of the Development of Wildman Street.
Creators: name: Elsworth, Daniel W
name: Whitehead, Samuel
name: Dawson, Jo
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 239-247
description: A watching brief on groundworks at a development site in Kendal was undertaken by Greenlane Archaeology. This note considers documentary evidence for the development of the area before describing the findings of the watching brief. It is suggested that the medieval finds recovered had been deposited in fields belonging to the grange, which were subsequently developed into 'burgage' plots from the 16th century onwards. Based on the archaeological evidence, use of the term 'burgage' and the depiction of properties on historic maps might not always be an indication of medieval origin. LD
A Roman Coin Hoard from Morecambe Bay and its Possible Implications.
Creators: name: Shotter, David C A
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 229-233
description: Note describing a hoard of fifty Roman copper coins of the later third century AD, found in 2008 to the north of Carnforth. The historical context is discussed, and other relevant hoards from the region are noted. It is suggested that the later Roman defence of the north-west coast may have been considerably more extensive and coherent than thought, and that its purpose may not have been solely military but may have been equally directed towards the preservation through commerce of a Romanised way of life. LD
Part of an Eagle Mount from Beckfoot.
Creators: name: Cracknell, Philip M
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 227-229
description: Note describing in detail a fragment of a copper alloy eagle mount dating to the late second century AD or the first or second quarter of the third century, found near both the Roman fort and the Roman cemetery at Beckfoot. Parallels from elsewhere are cited, and the Beckfoot example is classified as a Type II rather than a Type I mount. LD
Supplementary document for Extended depth of field for Fresnel zone aperture camera via fast passive depth estimation - 6892439.pdf
Creators: name: Yang, Chen
name: Ni, Cong
name: Xinye, Zhang
name: Li, Yusen
name: Zhai, Yusheng
name: He, Weiji
name: Zhang, Wenwen
name: Chen, Qian
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: 1. The reconstructions of resolution target at 150mm-250mm using PSF at 130mm.
Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6897516.pdf
Creators: name: He, Liu
name: Lan, Zhihao
name: Yang, Yuting
name: ren, qun
name: You, JianWei
name: Sha, Wei
name: Wu, Liang
name: Yao, Jian-Quan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary material
Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6904649.pdf
Creators: name: He, Liu
name: Lan, Zhihao
name: Yang, Yuting
name: ren, qun
name: You, JianWei
name: Sha, Wei
name: Wu, Liang
name: Yao, Jian-Quan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary material
The cost-utility of first-line pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer: A literature review and decision analytic Markov model
Creators: name: Wayi-Wayi, Grace
Publisher: name: figshare
Year: 2016
Subjects: subject: 140208 Health Economics
subject: FOS: Economics and business

description: Background: A recent study demonstrated that the addition of pertuzumab to trastuzumab plus docetaxel for the treatment of HER2-postive MBC significantly increases progression-free (PFS) and overall-survival (OS). This study aims to empirically examine evidence of the clinical-effectiveness and cost-effectiveness of pertuzumab in combination with trastuzumab plus docetaxel from an NHS perspective.   Methods: A literature review was conducted in line with the principles provided by the Cochrane handbook. Six major electronic databases were used to conduct the search, and the studies identified were assessed for quality. Data on the clinical-effectiveness of pertuzumab, trastuzumab and docetaxel were used to build a Markov model consisting of 3 health states (PFS, DP and death) in order to follow the course of a cohort 1000 patients with MBC. Information on AEs, response rates, transition probabilities etc., were derived from the CLEOPATRA pivotal trial.    Results: A total of 4 articles reporting the results of the CLEOPATRA trial were found as well as 3 studies on its cost-effectiveness. The findings of the CLEOPATRA trial demonstrated that the addition of pertuzumab to trastuzumab and docetaxel significantly improved PFS and extended OS with no increase in cardiotoxicity compared to the control (placebo, trastuzumab and docetaxel). Two of the studies on the cost-effectiveness of this regimen that were identified were non-UK based. The only UK-based study was conducted by the manufacture of pertuzumab and trastuzumab using immature OS data, this study has not been published. The addition of pertuzumab to trastuzumab and docetaxel resulted in 727.6 QALY gain and was associated with an additional lifetime cost of £220,606,111, resulting in an ICER of £303,190/QALY gained. Deterministic SA demonstrated that this regime is unlikely to be cost-effective even under the most favourable assumptions. Conclusion: DTP as first-line treatment for HER2-positive MBC does not represent a cost-effective use of NHS resources. ..
title: OFROM: interview avec unifr16a05m
Creators: name: Delafontaine, François
name: Balmat, Bérénice
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.d4609u19.v2#b9be058e0d1dd93448e26a09a357d8fb1871c153
Whatever Happened to Inglewood Forest? Landscape and Settlement Evolution in Inglewood Forest since Medieval Times .
Creators: name: Hope, Douglas G
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 149-164
description: This paper charts the progress of the conversion of Inglewood Forest (covering the area between Penrith and Carlisle) from the medieval common 'waste' to cultivated agricultural land and assesses the effects of the 18th and 19th century Parliamentary enclosures, concentrating on the Skelton Enclosure Award area and the Broad Field area of the Inglewood Enclosure Award. The enclosure of Inglewood Forest had a profound effect on the landscape, but its economic and social impact is less obvious.
Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6906431.pdf
Creators: name: He, Liu
name: Lan, Zhihao
name: Yang, Yuting
name: ren, qun
name: You, JianWei
name: Sha, Wei
name: Wu, Liang
name: Yao, Jian-Quan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary material
EPIC Adapted Food Frequency Questionnaire
Creators: name: Greaney, Cian
name: Bohan, Katie
name: Tecklenborg, Sarah
name: Casserly, Brian
name: Green, James
name: VAN DE VEN, PEPIJN
name: Robinson, Katie
name: Tierney, Audrey
Publisher: name: figshare
Year: 2022
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences

description: Food Frequency Questionnaire adapted from the European Prospective Investigation of Cancer and validated for use in the Irish population.
L'environnement du Mont Beuvray (Collection "Bibracte", 1, notice)
Creators: name: Buchsenschutz, Olivier
name: Richard, Hervé
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Résumé et sommaire. L'intégralité de la publication sera bientôt accessible sur OpenEdition
title: Commission d'Instruction de la Cour de justice de la République, "Arrêt portant renvoi devant la Cour de justice de la République : Prononcé au siège de la Cour de justice de la République le 17 juillet 1998"
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Faits, p. 87-89.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111233429220
Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6824991.pdf
Creators: name: He, Liu
name: Lan, Zhihao
name: Yang, Yuting
name: ren, qun
name: You, JianWei
name: Sha, Wei
name: Wu, Liang
name: Yao, Jian-Quan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: ID #518922
Introduction to World Religions Syllabus
Creators: name: Crow, John L.
Publisher: name: figshare
Year: 2016
Subjects: Religious Studies
History

description: Introduction to World Religions syllabus. This class explores and engages the history, religious beliefs, and practices of numerous cultures around the world over a vast time span. The class gives an opportunity to survey the variety of religious traditions, and realize the immense diversity of practices and beliefs placed under the category of religion. It also gives a broad exposure to varying worldviews that have influenced the ways people live their lives and interact with each other. This course highlights certain aspects of culture that interact with and/or are integral to the category of religion. It also challenges preconceived notions about a variety of topics related to religion including race, class, gender, religious texts, beliefs, practices, politics, including colonialism, economics, violence, and how societies have responded to religions that have emerged in that last few centuries. These issues will be explored within the framework of historical and cultural theory.
Robust Ensemble Classi er Combination Based on Noise Removal with One-Class SVM
Creators: name: Catak, Ferhat Ozgur
Publisher: name: figshare
Year: 2016
Subjects: subject: Theoretical Computer Science
subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology

description: In machine learning area, as the number of labeled input samples becomes very large, it is very dicult to build a classication model because of input data set is not t in a memory in training phase of the algorithm, therefore, it is necessary to utilize data partitioning to handle overall data set. Bagging and boosting based data partitioning methods have been broadly used in data mining and pattern recognition area. Both of these methods have shown a great possibility for improving classication model performance. This study is concerned with the analysis of data set partitioning with noise removal and its impact on the performance of multiple classier models. In this study, we propose noise ltering preprocessing at each data set partition to increment classier model performance. We applied Gini impurity approach to nd the best split percentage of noise lter ratio. The ltered sub data set is then used to train individual ensemble models.
Sustainable synthesis of imidazoles using a catalyst-free approach and ethyl lactate as a bio-based green solvent in the Debus-Japp-Radziszewski reaction
Creators: name: da Silva, Flavia Martins
name: Jones, Joel
name: Muñoz, July A. Hernández
name: de Azevedo, Priscila Nogueira
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Mental Health

description: A highly substituted family of imidazoles is effectively obtained through the Debus-Japp-Radziszewski reaction. In this process, benzil, ammonium acetate, and various benzaldehydes react in a particularly notable solvent: ethyl lactate (EL). This bio-based solvent, derived from biomass fermentation, stands out not only for its sustainable origin but also for its remarkable properties. Ethyl lactate is biodegradable, health-risk-free, is easily recyclable, and is non-corrosive, categorizing it as an exemplary green solvent. The multicomponent reaction, carried out under these conditions, eliminates the need for a catalyst, resulting in products with good yields. The isolation of the products is very simple, requiring only filtration, as they are insoluble in the solvent. In this way, this methodology aligns with various principles of green chemistry, emphasizing the strategic choice of ethyl lactate. This choice has a positive impact on the synthesis of imidazoles, well-known for their pharmacological properties.
Sterowanie ślizgowe napędem bezpośrednim z silnikiem synchonicznym z magnesami trwałymi
Creators: name: Brock, Stefan
Publisher: name: figshare
Year: 2016
Subjects: subject: 91302 Automation and Control Engineering
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: 90603 Industrial Electronics

description: Implementation of sliding mode control to direct drive with permanent magnet synchronous motor

This paper focuses on the discrete implementation of the sliding mode controller to direct drive. To avoid the chattering the boundary layer is used. Additional integrator is used to eliminate steady state errors. The tuning method for variable system parameters is presented. Simulation results show that the control approach can decrease the tracking error, enhance the system's robustness and attenuate high frequency chattering in the control signal.

W pracy przedstawiono dyskretną implementację układu sterowania ślizgowego dla napędu bezpośredniego. Dla wyeliminowania szybkich przełączeń zastosowano strefę graniczną, a dodatkowy człon całkujący eliminuje uchyb ustalony. W pracy przedstawiono zasady doboru
nastaw regulatora dla zmiennych parametrów układu. Rozważania teoretyczne zilustrowano badaniami symulacyjnymi.
Datasets and Source Code for 'Estimating large-scale snow depth based on dual polarimetric radar index from Sentinel-1 GRD data: A case study in the Scandinavian Mountains'
Creators: name: Feng, Tianwen
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 370403
subject: Geoscience data visualisation
classificationCode: 370402
subject: Earth and space science informatics

description: This repository contains the datasets and source code associated with the research paper titled "Estimating large-scale snow depth based on dual polarimetric radar index from Sentinel-1 GRD data: A case study in Scandinavian Mountains." The algorithm introduced in this paper is implemented on the Google Earth Engine (GEE) platform, leveraging its powerful geospatial data processing capabilities.The implementation details and the computational approaches are thoroughly documented in the provided source code, facilitating replication and further research based on our methodology. For direct access to the Google Earth Engine implementation, please visit: [https://code.earthengine.google.com/?accept_repo=users/zhuoerbufan8023/DpRSE].Additionally, the dataset used in our study is made available here to support transparency and enable reproducibility of our findings.This repository aims to provide comprehensive resources for researchers interested in snow depth estimation using radar data, enhancing the accessibility of our research and encouraging further exploration in this field.
title: OFROM: interview avec unifr16a03m
Creators: name: Delafontaine, François
name: Quarroz
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.24d5mcb7.v2#a921d2881e5c8aee5512176423feb5b1bfdd9950
Roman Reiter Memorial Stones from Kirkby Thore .
Creators: name: Edwards, B J N
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 137-148
description: Five of the twenty-five Roman cavalryman's memorials found in Britain of the type known as Reiter stones come from Cumbria. Three of these have had no published illustrations other than engravings in 1875. This paper presents up-to-date photographs of the three with comments on the differences between the engravings and the actual stones. In introducing these, some consideration is given to the type as a whole. A reconstruction drawing is offered of the figure on one stone, which survives only partially, and the significance of the three sculptures for the nature of the garrison of the fort at Kirkby Thore is considered.
The Roman Military Occupation of Northern England .
Creators: name: Breeze, David J
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 113-136
description: A review of the evidence for Roman military deployment in northern England and for defended civil settlements rejects the suggestion that the area had serious internal security problems. The evidence for the proposed abandonment of some forts in the later third century is reconsidered, a review of the problems of the dating evidence for the occupation of forts in the third century is offered, and a range of possibilities is suggested for the presence of defences round civil settlements.
Manufacturing Identities. An Archaeological Approach to Industrialisation and the Formation of Modern Cumbria .
Creators: name: Newman, Richard
Publisher: name: Archaeology Data Service
Year: 2013

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 11, 97-112
description: This paper argues that in Cumbria one of the key cultural aspects that helped produce some of today's differences in local identity is industrialisation and specifically past variations in the experience of industrialisation. An archaeological approach is taken by using the evidence of physical change in the landscape and of access to goods.
IPERION HS D7.5 User Forum and Organisation report on activities
Creators: name: Strlic, Matija
name: Anžur, Lana Nastja
name: Chaban, Antonina
name: Gibson, Adam
name: STRIOVA, JANA
name: MAZZEO, ROCCO
name: Benassi, Laura
name: Novotny, Jakub
Publisher: name: Zenodo
Year: 2024
Subjects: user communnities
engagement
heritage science

description: The IPERION HS (IPHS) User Forum represents a supportive learning and engagement environment called Heritage Science Academy. The HS Academy (#HSAcademy) is an online environment designed to support a global community of users and potential users of IPHS facilities, through online seminars and training videos, as well as through social media. The aim of the HS Academy is to promote the IPHS facilities and excellent science carried out through TransNational Access (TNA) projects and joint research activities, and also to engage the wider heritage science community in current issues related to heritage science policy and the wider societal issues that impact on the development of heritage science, from climate to social change. The HS Academy promotes interdisciplinarity through a holistic engagement with topics across STEM and SSH disciplines. The HS Academy webinar series has run monthly since April 2021 and Current topics lecture series since September 2022. We also conducted an extensive questionnaire on the HS demographic between November 2022 – February 2023. In total, we collected 413 responses to the questionnaire. All these activities have high online visibility, both through the IPHS website and through related social media, and truly global engagement is visible. An HS Academy anchor has been established on the professional social networking platform LinkedIn, which has also been an important tool. The LinkedIn Online Forum explores the links with the LinkedIn interest groups, where further interest in IPERION HS services can be developed.
Export Diversification and Role of Export Processing Zones (EPZ) in Bangladesh.pdf
Creators: name: A N M Asaduzzaman Fakir
name: Miah, Mohammad Shahin
name: Md. Shakawat Hossain
Publisher: name: figshare
Year: 2016
Subjects: subject: 150308 International Business
subject: FOS: Economics and business

description: This paper explores the history of EPZ in Bangladesh, its legislative structure for operation andperformance. This study has explored the contribution of EPZ in Bangladesh and how much itcontributes to country’s economy in terms of employment, export and investment. The yearlygrowth rate of GDP is used as a dependent variable. It argues that developing countries cantake advantage of the opportunities provided by EPZs for the acquisition of superiortechnology, upgrading of labor and managerial skills, and greater access to foreign markets.The paper then examines the development and economic significance of EPZs in Bangladesh.Export diversification and export-oriented activities, the development of stronger backwardlinkages, and the upgrading of the export-oriented legislation in Bangladesh are addressed.This study also tried to explore the contribution of EPZ in national economy, branding ofproducts, export-incentives, infrastructures, investments & prospects including constraints ofEPZ in Bangladesh.
The Use of Responsibility Accounting in Garments Industry in Bangladesh.pdf
Creators: name: A N M Asaduzzaman Fakir
name: Islam, Muhammad Zahirul
Publisher: name: figshare
Year: 2016
Subjects: subject: 150105 Management Accounting
subject: FOS: Economics and business

description: Responsibility accounitng is the collection, summarization and reporting of financialinformation about various decision centers (responsibility centers) throughout anorganization; also called activity accounting or profitability accounting.This is an effort toexamine the real world practice of responsibility accounting system in listed Garments ofBangladesh. It also focuses on the overall satisfaction of responsibility accounting system andthe significance of each element (i.e assigning responsibility, estabilishing performancemeasures, evaluating performance, assigning rewards and responsibility center) onresponsibility accoutning sytem. To achieve these objectives all listed garments have beensurveyed. Findings by survey of garments’ each variable on resposibility accounting revealthat all elements are important for overall satisfaction of resposibility accounting system anddescriptive statistics show that the satisfaction of responsibilty accounting system of all listedgarments industry sustains in satisfactory level
Therapeutic strategies in FcγIIA receptor-dependent thrombosis and thromboinflammation as seen in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT)
Creators: name: Müller, Luisa
name: Dabbiru, Venkata A.S.
name: Schönborn, Linda
name: Greinacher, Andreas
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Fcγ-receptors (FcγR) are membrane receptors expressed on a variety of immune cells, specialized in recognition of the Fc part of immunoglobulin G (IgG) antibodies. FcγRIIA-dependent platelet activation in platelet factor 4 (PF4) antibody related disorders have gained major attention, when these antibodies were identified as the cause of the adverse vaccination event termed vaccine-induced immune thrombocytopenia and thrombosis (VITT) during the Covid-19 vaccination campaign. With the recognition of anti-PF4 antibodies as cause for severe spontaneous and sometimes recurrent thromboses, their clinical relevance extended far beyond heparin-induced thrombocytopenia (HIT) and VITT. Patients developing these disorders show life-threatening thromboses and the outcome is highly dependent on effective treatment. This narrative literature review summarizes treatment options for HIT and VITT that are currently available for clinical application and provide the perspective toward new developments. Nearly all these novel approaches are based on in vitro, preclinical observations, or case reports with only limited implementation in clinical practice. The therapeutic potential of these approaches still needs to be proven in larger cohort studies to ensure treatment efficacy and long-term patient safety.