cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
3.5 keV X-ray line and R-Parity Conserving Supersymmetry
Creators: name: Dutta, Bhaskar
name: Gogoladze, Ilia
name: Khalid, Rizwan
name: Shafi, Qaisar
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present some R-parity conserving supersymmetric models which can accommodate the 3.5 keV X-ray line reported in recent spectral studies of the Perseus galaxy cluster and the Andromeda galaxy. Within the Minimal Supersymmetric Standard Model (MSSM) framework, the dark matter (DM) gravitino (or the axino) with mass of around 7 keV decays into a massless neutralino (bino) and a photon with lifetime ~10^{28} sec. The massless bino contributes to the effective number of neutrino species N_eff and future data will test this prediction. In the context of NMSSM, we first consider scenarios where the bino is massless and the singlino mass is around 7 keV. We also consider quasi-degenerate bino-singlino scenarios where the mass scale of DM particles are O(GeV) or larger. In such a scenario we require the mass gap to generate the 3.5 keV line. We comment on the possibility of a 7 keV singlino decaying via R parity violating couplings while all other neutralinos are heavy.
description: 16 pages, 4 figures, updated to reflect journal version
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Creators: name: Rai, Shivam
name: Grockowiak, Elodie
name: Hansen, Nils
name: Luque Paz, Damien
name: Stoll, Cedric B
name: Hao-Shen, Hui
name: Mild-Schneider, Gabriele
name: Dirnhofer, Stefan
name: Farady, Christopher J
name: Méndez-Ferrer, Simón
name: Skoda, Radek C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/67/1990/2331
/692/308/2778
/692/4028/67/1990/2331
/64/60
/64/110
/13/1
/13/21
/13/31
/13/51
/13/100
/14
/14/19
/14/63
/38/91
/38/90
/38/77
/38/39
article

description: Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels and expression of IL-1 receptors on hematopoietic progenitors and stem cells correlate with JAK2-V617F mutant allele fraction in peripheral blood of patients with MPN. We show that the source of IL-1β overproduction in a mouse model of MPN are JAK2-V617F expressing hematopoietic cells. Knockout of IL-1β in hematopoietic cells of JAK2-V617F mice reduces inflammatory cytokines, prevents damage to nestin-positive niche cells and reduces megakaryopoiesis, resulting in decrease of myelofibrosis and osteosclerosis. Inhibition of IL-1β in JAK2-V617F mutant mice by anti-IL-1β antibody also reduces myelofibrosis and osteosclerosis and shows additive effects with ruxolitinib. These results suggest that inhibition of IL-1β with anti-IL-1β antibody alone or in combination with ruxolitinib could have beneficial effects on the clinical course in patients with myelofibrosis.
The Consequences of Prisonization for Juveniles: A Theoretical and Methodological Framework for Research
Creators: name: Greve, Werner
Publisher: name: Universität Tübingen
Year: 1998
Subjects: subject: Jugendstrafvollzug
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte
Tethering of cellulose synthase to microtubules dampens mechano-induced cytoskeletal organization in Arabidopsis pavement cells.
Creators: name: Schneider, René
name: Ehrhardt, David W
name: Meyerowitz, Elliot M
name: Sampathkumar, Arun
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/449/448/1365
/631/449/448/1408
/631/449/2653/1359
article

description: Funder: Howard Hughes Medical Institute (HHMI); doi: https://doi.org/10.13039/100000011
description: Mechanical forces control development in plants and animals, acting as cues in pattern formation and as the driving force of morphogenesis. In mammalian cells, molecular assemblies residing at the interface of the cell membrane and the extracellular matrix play an important role in perceiving and transmitting external mechanical signals to trigger physiological responses. Similar processes occur in plants, but there is little understanding of the molecular mechanisms and their genetic basis. Here, we show that the number and movement directions of cellulose synthase complexes (CSCs) at the plasma membrane vary during initial stages of development in the cotyledon epidermis of Arabidopsis, closely mirroring the microtubule organization. Uncoupling microtubules and CSCs resulted in enhanced microtubule co-alignment as caused by mechanical stimuli driven either by cell shape or by tissue-scale physical perturbations. Furthermore, micromechanical perturbation resulted in depletion of CSCs from the plasma membrane, suggesting a possible link between cellulose synthase removal from the plasma membrane and microtubule response to mechanical stimuli. Taken together, our results suggest that the interaction of cellulose synthase with cortical microtubules forms a physical continuum between the cell wall, plasma membrane and the cytoskeleton that modulates the mechano-response of the cytoskeleton.
Electrophysiological Evidence that Ethanol Alters Function of Medial Septal Area Without Affecting Lateral Septal Function
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Evidence is provided in this manuscript that ethanol acts directly on neurons in the medial septal area (MSA). Initially, the electrophysiological characteristics of MSA neurons in freely moving rats were characterized and found similar to that observed in rats anesthetized with urethane, but not chloral hydrate. Therefore, urethane was used to evaluate the effects of ethanol in anesthetized rats. The conclusion that ethanol influences neural function in the MSA is based on electrophysiological data that ethanol (0.75–3.0 g/kg i.p.) suppresses neural firing of medial septal cells in urethane-anesthetized as well as in unanesthetized rats in a dose-related fashion. Concurrent with the suppression of firing rate, the rhythmic bursting pattern of activity of MSA neurons is disrupted by ethanol. The changes observed in the MSA could not be attributed to an indirect action of ethanol on afferents from the lateral septum to the MSA, because ethanol did not alter neural activity of cells in the lateral septum. These data indicate that ethanol does not have a common action on all neurons. Neural activity in the MSA recovered from the acute action of ethanol at a time when blood ethanol levels were near maximal, indicating an acute tolerance to this effect of ethanol. The time course of change in neural activity in the MSA was highly correlated with the time course of a measure of behavioral sedation, but not the hypothermia produced by ethanol. Thus, the work in this manuscript supports the view that ethanol has selective actions on MSA neurons in the rat septal area and that these actions may influence the behavioral sedation induced by ethanol.
Development, implementation and validation of resource-stratified guidelines in low-income and middle-income countries: a scoping review protocol.
Creators: name: Griswold, Dylan
name: Venturini, Sara
name: Carney, Nancy
name: Rubiano, Andres M
name: Hutchinson, Peter John
name: Kolias, Angelos G
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Evidence based practice
1506
1694
protocols & guidelines
quality in health care
international health services

description: Peer reviewed: True
description: Acknowledgements: The authors would like to thank Isla Kuhn, Head of Medical Library Services, University of Cambridge Medical Library for her assistance in developing the search strategy.
description: INTRODUCTION: Nearly every field of medicine has some form of clinical practice guidelines. However, only within the past 5-10 years has the medical community acknowledged the need for well-developed guidelines tailored to the local healthcare needs and the resources available. In most low-income and middle-income countries (LMICs), healthcare workers depend on guidelines developed in high-income countries (HICs), yet many interventions validated in a HIC are ineffective when implemented in an LMIC. The variation in infrastructure, medical personnel, technology and environmental conditions exhibited in LMICs relative to HICs necessitates a careful appraisal of the evidence base used in clinical guideline recommendations. This review aims to map the use of resource-stratified guidelines across all fields of medicine. The review seeks to answer three questions for the identified guidelines: (1) what was the method of development, (2) have they been implemented and, if so, (3) have they been validated. METHODS: The search strategy will aim to locate studies from inception to November 2021. An initial limited search of PubMed and Scopus was undertaken to identify articles on the topic. The text words contained in the titles and abstracts of relevant articles, and the index terms used to describe the articles were used to develop a full search strategy for PubMed and Scopus. This scoping review will be conducted in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews. Data to be extracted from each study will include population characteristics of both developers and intended implementation population, medical specialty, validation status, method of guideline development, whether the study is consensus or evidence-based in addition to a summary of recommendations for practice. ETHICS AND DISSEMINATION: Ethical approval is not required for this review. The plan for dissemination is to publish review findings in a peer-reviewed journal.
Site-Specific Enhancement of γ-Aminobutyric Acid-Mediated Inhibition of Neural Activity by Ethanol in the Rat Medial Septal Area
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Because of uncertainty concerning the interaction of ethanol with γ-aminobutyric acid (GABA) receptor-mediated events, the present work was designed to investigate the effect of ethanol on GABA transmission in the rat septal area using behavioral and electrophysiological techniques. Microinjection of the GABAA agonist muscimol into the medial septal area (MSA) enhanced, and bicuculline administration antagonized, ethanol-induced impairment of the aerial righting reflex. Microinjection of these drugs into the lateral septum (LSi) did not influence this measure of ethanol-induced sedation. Furthermore, intraseptal injections of muscimol or bicuculline in saline-treated rats had no effect on the aerial righting reflex. These data suggest that the MSA plays a critical modulatory role in the sedative actions of ethanol. To assess the effect of ethanol on muscimol responses in the MSA and LSi at the cellular level, GABA was applied by iontophoresis to rhythmically bursting neurons of the MSA and to cells in the LSi. The magnitude of the resultant inhibition by GABA on these cells was assessed before and after systemic administration of ethanol. Ethanol enhanced GABA-mediated inhibition of MSA neural activity, but did not alter GABA-mediated inhibition of cellular activity in the LSi. In contrast, the inhibition of cellular activity in the MSA, caused by a maximally effective concentration of the benzodiazepine flurazepam, was not altered by ethanol. Other work in the MSA demonstrated that electrical stimulation of the fimbria caused an inhibition of ongoing single unit activity that was reduced by concurrent application of bicuculline. The duration of this electrically elicited inhibition in the MSA was enhanced after ethanol injection and then recovered to base-line levels. In addition, ethanol (1.5 mg/kg) caused an enhancement of the inhibition induced by nipecotic acid, a GABA uptake inhibitor. These findings demonstrate that GABA-mediated neural inhibition is enhanced by ethanol in the MSA but not the LSi, indicating that the actions of ethanol on GABA-induced inhibition can be site specific. It is proposed that the cellular action of ethanol may depend upon a specific molecular composition of the GABA receptor complex which may vary at selected sites in the brain.
VI. Nomenclature and Classification of Purinoceptors
Creators: name: Fredholm, Bertil
name: Williams, Michael
name: Abbracchio, Maria
name: Jacobson, Kenneth
name: Harden, Kendall
name: Daly, John
name: Burnstock, Geoffrey
name: Leff, Paul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: 8
Fermion-dimer scattering using an impurity lattice Monte Carlo approach and the adiabatic projection method
Creators: name: Elhatisari, Serdar
name: Lee, Dean
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present lattice Monte Carlo calculations of fermion-dimer scattering in the limit of zero-range interactions using the adiabatic projection method. The adiabatic projection method uses a set of initial cluster states and Euclidean time projection to give a systematically improvable description of the low-lying scattering cluster states in a finite volume. We use Lüscher's finite-volume relations to determine the s-wave, p-wave, and d-wave phase shifts. For comparison, we also compute exact lattice results using Lanczos iteration and continuum results using the Skorniakov-Ter-Martirosian equation. For our Monte Carlo calculations we use a new lattice algorithm called impurity lattice Monte Carlo. This algorithm can be viewed as a hybrid technique which incorporates elements of both worldline and auxiliary-field Monte Carlo simulations.
description: 23 pages, 7 figures, 4 tables, version published in Phys. Rev. C
Lyapunov Functions Family Approach to Transient Stability Assessment
Creators: name: Vu, Thanh Long
name: Turitsyn, Konstantin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Analysis of transient stability of strongly nonlinear post-fault dynamics is one of the most computationally challenging parts of Dynamic Security Assessment. This paper proposes a novel approach for assessment of transient stability of the system. The approach generalizes the idea of energy methods, and extends the concept of energy function to a more general Lyapunov Functions Family (LFF) constructed via Semi-Definite-Programming techniques. Unlike the traditional energy function and its variations, the constructed Lyapunov functions are proven to be decreasing only in a finite neighborhood of the equilibrium point. However, we show that they can still certify stability of a broader set of initial conditions in comparison to the traditional energy function in the closest-UEP method. Moreover, the certificates of stability can be constructed via a sequence of convex optimization problems that are tractable even for large scale systems. We also propose specific algorithms for adaptation of the Lyapunov functions to specific initial conditions and demonstrate the effectiveness of the approach on a number of IEEE test cases.
The genus Flavopimpla Betrem (Insecta: Hymenoptera: Ichneumonidae) from Vietnam, with a new country record
Creators: name: Pham, Thi Nhi
Publisher: name: Journal of Vietnamese Environment
Year: 2018

description: Up to date, three species of the genus Flavopimpla have been known from Vietnam, of which two species were described as new on the basis of the material collected from the country, viz. F. lanugo Pham, Broad & Wägele, 2013 from Xuan Son NP, Phu Tho Province and F. vinhcuuensis Pham, Broad & Wägele, 2013 from Phu Ly, Dong Nai Province. Resulted from recent field survey, one species Flavopimpla nigromaculata (Cameron) is recorded for the first time from the country and included to the previous key to already known Flavopimpla species of Vietnam. In addition, the distribution range of F. lanugo is extended northwards. Cho đến nay, 3 loài thuộc giống ong cự Flavopimpla đã được ghi nhận ở Việt Nam, trong đó hai loài được miêu tả gần đây dựa trên các mẫu vật thu được trong nước bao gồm F. lanugo Pham, Broad & Wägele, 2013 ở Vườn Quốc gia Xuân Sơn, tỉnh Phú Thọ và F. vinhcuuensis Pham, Broad & Wägele, 2013 ở Phủ Lý, tỉnh Đồng Nai. Dựa trên các chuyến khảo sát gần đây, loài Flavopimpla nigromaculata (Cameron) được ghi nhận lần đầu tiên cho khu hệ côn trùng Việt Nam và được đưa vào khóa định loại tới loài của giống này đã có trước đây. Bên cạnh đó, vùng phân bố của loài F. lanugo cũng được ghi nhận mở rộng về phía bắc.
description: Journal of Vietnamese Environment, Vol 9 No 1 (2018)
Charm contribution to bulk viscosity
Creators: name: Laine, M.
name: Sohrabi, Kiyoumars A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the range of temperatures reached in future heavy ion collision experiments, hadronic pair annihilations and creations of charm quarks may take place within the lifetime of the plasma. As a result, charm quarks may increase the bulk viscosity affecting the early stages of hydrodynamic expansion. Assuming thermalization, we estimate the charm contribution to bulk viscosity within the same effective kinetic theory framework in which the light parton contribution has been computed previously. The time scale at which this physics becomes relevant is related to the width of the transport peak associated with the trace anomaly correlator, and is found to be < 20 fm/c for T > 600 MeV.
description: 7 pages. v2: presentation streamlined
title: Das Feld der (literarischen) Übersetzung in der Volksrepublik Polen
Creators: name: Wnorowska, Izabela
Year: 2021

description: Diese Masterarbeit setzt sich zum Ziel, das Feld der (literarischen) Übersetzung in der Volksrepublik Polen (1945-1989) zu untersuchen. Sie fragt danach, inwiefern die Autonomisierungs- und Institutionalisierungsprozesse dieses Feldes in die zweite Hälfte des 20. Jhs. zu datieren sind. Methodisch kommt Bourdieus Instrumentarium zur Beschreibung sozialer Wirklichkeiten (Feldtheorie, Habitus- und Kapitalsortentheorie) zur Anwendung. In diesem Sinne werden die Beziehungen des Feldes des Übersetzens zum Feld der Macht, die inneren Strukturen und Institutionen des Feldes sowie die Kapitalsorten und der Habitus der Hauptakteur*innen unter die Lupe genommen. Als Fallbeispiel wird der Sammelband „Über die Kunst des Übersetzens“ (1955) herangezogen, der als erste Sammlung von Beiträgen zur Theorie des Übersetzens in Polen anzusehen ist.
Differential Effects of Chronic Antidepressant Treatment on Swim Stress- and Fluoxetine-Induced Secretion of Corticosterone and Progesterone
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Hypersecretion of cortisol occurs in numerous patients with major depression and normalizes with clinical recovery during the course of chronic antidepressant treatment. These clinical data suggest that investigation of the effects of antidepressant treatments on the regulation of the brain-pituitary-adrenal axis may assist in elucidating the therapeutic basis of antidepressant actions. In the present investigation, both swim stress and acute fluoxetine challenge increased release of corticosterone and progesterone to reflect an activation of the brain pituitary-adrenal axis. The effects of chronic antidepressant treatment (21 days) on corticosterone and progesterone secretion induced by these challenges were investigated. Chronic fluoxetine treatment (5 mg/kg/day) completely blocked the increased secretion of corticosterone and progesterone in response to the acute fluoxetine challenge. Chronic treatment with desipramine, imipramine or amytriptyline (15 mg/kg/day) also markedly attenuated fluoxetine-induced corticosterone and progesterone secretion. However, chronic treatment with the monoamine oxidase inhibitors, phenelzine (5 mg/kg) and tranylcypromine (5 mg/kg), did not affect this hormonal response to acute fluoxetine challenge. Plasma levels of fluoxetine after acute challenge were not significantly different for the various chronic antidepressant treatment conditions from the chronic saline controls; therefore, an increase in the metabolism of fluoxetine can not explain the antagonism of the fluoxetine-induced hormonal response after chronic antidepressant treatment. In contrast to the effects of selected antidepressants on acute fluoxetine-induced steroid release, chronic treatment with imipramine (20 mg/kg/day), fluoxetine (5 mg/kg/day) or phenelzine (5 mg/kg) did not significantly alter this swim stress-induced corticosterone or progesterone secretion. Because chronic fluoxetine and tricyclic antidepressant drugs blocked the acute action of fluoxetine to increase adrenal cortical secretion, but did not alter swim stress-induced secretion of these steroids, we propose that distinct neurochemical mechanisms control fluoxetine and swim stress-induced steroid release. We speculate that the substantial adaptive response to those chronic antidepressant treatments, which minimize the effect of acute fluoxetine challenge to increase in corticosterone and progesterone secretion, may be relevant to the therapeutic actions of these drugs.
ኢትዮጵያውያን በሄሮዶቱስ የታሪክ መጽሐፍ ውስጥ
Creators: name: Tsegaye, Anteneh Biru
Publisher: name: Zenodo
Year: 2023

description: በሄሮዱቱስ የታሪክ መጽሐፍ ኢትዮጵያውያን ከዋነኛ የታሪክ ተዋናዮች ውስጥ ናቸው። የሚከተሉት አንቀጾች ከሄሮዱቱስ የታሪክ መጽሐፍ የተተረጎሙ ኢትዮፕያውያንን የሚመለከቱ ትረካዎች ናቸው። ሄሮዶቱስ ከ፬፻፹፬ ቅልክ - ፬፻፳፭ ቅልክ የነበረ ፣ በወቅቱ ባካባቢው የነበረውን ታሪክ እና ትርክት ሰንዶ ያለፈ የጽርእ ሰው ነበር።
Nematic and spin-charge orders driven by hole-doping a charge-transfer insulator
Creators: name: Fischer, Mark H.
name: Wu, Si
name: Lawler, Michael
name: Paramekanti, Arun
name: Kim, Eun-Ah
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Recent experimental discoveries have brought a diverse set of broken symmetry states to the center stage of research on cuprate superconductors. Here, we focus on a thematic understanding of the diverse phenomenology by exploring a strong-coupling mechanism of symmetry breaking driven by frustration of antiferromagnetic order. We achieve this through a variational study of a three-band model of the CuO$_2$ plane with Kondo-type exchange couplings between doped oxygen holes and classical copper spins. Two main findings from this strong-coupling multi-band perspective are 1) that the symmetry hierarchy of spin stripe, charge stripe, intra-unit-cell nematic order and isotropic phases are all accessible microscopically within the model, 2) many symmetry-breaking patterns compete with energy differences within a few meV per Cu atom to produce a rich phase diagram. These results indicate that the diverse phenomenology of broken-symmetry states in hole-doped antiferromagnetic charge-transfer insulators may indeed arise from hole-doped frustration of antiferromagnetism.
title: Die Verbalkategorie "Modus" im Sprachkontakt zwischen Latein und Griechisch
Creators: name: Pinna, Emanuela
Year: 2021

description: Diese Masterarbeit erforscht die Behandlung der Verbalkategorie „Modus“ im Sprachkontakt zwischen Latein und Griechisch, anhand von unterschiedlichen Kontaktsituationen, die auf der Basis von mehreren Quellen und Textsorten verschiedener Epoche analysiert werden. Das Ziel der Arbeit ist die Erlangung einer allgemeinen und vielfältigen Einsicht in den Umgang mit der Semantik dieser Kategorie des griechischen und lateinischen Verbalsystems. Nach einer vergleichenden Einleitung in das griechische und lateinische Modalsystem – unter besonderer Berücksichtigung von Konjunktiv und Optativ - fokussiert die Analyse auf drei ausgewählte Kontaktsituationen, und nämlich Übersetzungen, Briefkorrespondenzen und Code-Switching. Die durchgeführte Bearbeitung dieser Materialien hat es ermöglicht, eine Einsicht in die zahlreichen Möglichkeiten zu erhalten, wie die semantischen Werte der Modi in zweisprachigen lateinischen und griechischen Kontaktsituationen behandelt werden konnten, vor allem im Hinblick auf die angewendeten Strategien, um Modalkategorien wiederzugeben, die in der Muttersprache des Schreibenden nicht vorhanden sind (z.B. der griechische Optativ im Lateinischen), aber auch unter Berücksichtigung von Interferenzen der Muttersprache und von typischen Fehlern oder Tendenzen, die in Spracherscheinungen von Muttersprachlern der jeweils anderen Sprache vorkommen.
Induction of Novel Agonist Selectivity for the ADP-Activated P2Y1 Receptor Versus the ADP-Activated P2Y12 and P2Y13 Receptors by Conformational Constraint of an ADP Analog
Creators: name: Chhatriwala, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: ADP is the cognate agonist of the P2Y1, P2Y12, and P2Y13 receptors. With the goal of identifying a high potency agonist that selectively activates the P2Y1 receptor, we examined the pharmacological selectivity of the conformationally constrained non-nucleotide analog (N)-methanocarba-2MeSADP [(1′S,2′R, 3′S,4′R,5′S)-4-[(6-amino-2-methylthio-9H-purin-9-yl)-1-diphosphoryloxymethyl]bicyclo[3.1.0]hexane-2,3-diol] among the three ADP-activated receptors. Each P2Y receptor was expressed transiently in COS-7 cells, and inositol lipid hydrolysis was quantified as a measure of receptor activity. In the case of the Gi-linked P2Y12 and P2Y13 receptors, a chimeric G protein, Gαq/i, was coexpressed to confer a capacity of these Gi-linked receptors to activate phospholipase C. 2MeSADP (2-methylthio-ADP) was a potent agonist at all three receptors exhibiting EC50 values in the sub to low nanomolar range. In contrast, whereas (N)-methanocarba-2MeSADP was an extremely potent (EC50 = 1.2 ± 0.2 nM) agonist at the P2Y1 receptor, this non-nucleotide analog exhibited no agonist activity at the P2Y12 receptor and very low activity at the P2Y13 receptor. (N)-Methanocarba-2MeSADP also failed to block the action of 2MeSADP at the P2Y12 and P2Y13 receptors, indicating that the (N)-methanocarba analog is not an antagonist at these receptors. The P2Y1 receptor selectivity of (N)-methanocarba-2MeSADP was confirmed in human platelets where it induced the shape change promoted by P2Y1 receptor activation without inducing the sustained platelet aggregation that requires simultaneous activation of the P2Y12 receptor. These results provide the first demonstration of a high-affinity agonist that discriminates among the three ADP-activated P2Y receptors, and therefore, introduce a potentially important new pharmacological tool for delineation of the relative biological action of these three signaling proteins.
NURSING MECHANISM IN DISPOSING OF MEDICAL WASTE IN HEALTH FACILITIES
Creators: name: Norah.A.Alzahrani, Jameela.E.Allheani, Eman.S.Albarkatee, Fawzia.A.Alharbi, Roqaiah.M.Alnasheri, Bandar.M.Almuqati, Mona.T.Alnemari, Amal.H.Aallhyanei, Aisha.S.Shingary, Othman.S.Allhebi,Manal.S.Alqourashy,Mahdi.A.Alyamani, Nora.A.Maghrabi.
Publisher: name: Zenodo
Year: 2022

description: The aim of the study is the importance of having a written mechanism for the nursing staff to dispose of medical waste in health facilities (health centers or hospitals), the importance of having a secured and approved guide on medical waste by the Ministry of Health, the importance of having a trained nursing staff with high resistance to how to deal with illness and medical waste. In health facilities, the importance of having a place to store medical waste in a safe place, until it is disposed of by the Medical Waste Company (SEPCO). A questionnaire was created via the Google Drive website, and distributed to male and female health practitioners via the social networking site (WhatsApp), where responses to the questionnaire were obtained after a period of 5 months, where 850 questionnaires were distributed and 750 responses were received by those targeted. from research.
Keywords: Nursing mechanism, disposal of medical waste, health facilities
Reliability analysis of concrete-faced rockfill dams
Creators: name: Kartal, Murat Emre
Publisher: name: Zenodo
Year: 2010
Subjects: Dam-foundation-reservoir interaction
Drucker-Prager model
Probability of failure
Reliability analysis
Multi-linear kinematic hardening model
Lagrangian approach
Nonlinear response
Concrete-faced rockfill dam
Frictional contact
Contact elements

description: In this thesis, reliability analyses of concrete-faced rockfill dams under static and earthquake are performed considering dam-foundation-reservoir interaction. The effect of reservoir water on dam is considered using fluid finite elements based on the Lagrangian approach. Welded and friction contact are considered in various joints. One dimensional surface-to-surface contact elements obeying Coulomb’s friction law are used for frictional contacts. Earthquake response of the dam to deconvolved ground acceleration record is obtained. Non-reflecting boundary conditions are defined by viscous dampers. Drucker- Prager model is used for concrete and multi-linear kinematic hardening model is used for rockfill in the materially nonlinear analyses. Geometrically nonlinearity is also considered. FERUM, reliability analysis program, is combined with ANSYS finite element program in the reliability analysis of concrete-faced rockfill dam. The needed values used in the implicit limit state function are obtained by the established connection between these programs. Improved Rackwitz-Fiessler Method is used with Direct Coupled Method and Response Surface Method in the reliability analysis of the dam under static loads and used with Response Surface Method in the reliability analysis of the dam to earthquake. The probability of failure is computed for the selected critical points in the concrete slab. This thesis is composed of four chapters. In the first chapter, literature researches, used methods and formulations are given. In the second chapter, numerical model of th concrete-faced rockfill dam is given and the reliability analysis algorithm is explained. In the third chapter, initially, earthquake response of the dam is examined and then reliability of the dam under static and earthquake loads is studied. In the last chapter, it is deducted from the study that reservoir water decreases the reliability of the concete slab and to consider friction in the joints increases the reliability of the concete slab and in addition to this the proposals for further studies are given. This chapter is followed by the references.
Implications of Lorentz violation on Higgs-mediated lepton flavor violation
Creators: name: López-Osorio, M. A.
name: Martínez-Pascual, E.
name: Toscano, J. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The lepton flavor violating decay of the Higgs boson $H\to l_Al_B$ is studied within two qualitatively different extensions of the Yukawa sector: one renormalizable and the other nonrenormalizable; both incorporating Lorentz violation in a model-independent fashion. These extensions are characterized by Yukawa-like matrices, the former by a constant Lorentz 2-tensor $Y^{AB}_{μν}$, whereas the latter by a constant Lorentz vector $Y^{AB}_μ$. It is found that the experimental constraints on the decays $l_A\to l_Bγ$ severely restrict lepton flavor violating Higgs signals in the renormalizable scenario. In this context, it is found that $BR(H\to μ^\pm e^\mp)$ and $BR(H\to τ^\pm μ^\mp)$ cannot be larger than $10^{-18}$ and $10^{-11}$, respectively. In the nonrenormalizable scenario, transitions mediated by the Higgs or the $Z$ gauge boson are induced at tree level, and we find mild restrictions on lepton flavor violation. Using the experimental limits on the three-body decays $l_A \to l_B \bar{l}_Cl_C$ to constraint the vector $Y^{AB}_μ$, it is found that the branching ratio for the decays $H\to μ^\pm e^\mp$ is of about $4\times 10^{-9}$, more important, a branching ratio of $7\times 10^{-4}$ is found for the $τ^\pm μ^\mp$ mode. Accordingly, the decay $H \to τ^\pm μ^\mp$ could be at the reach of future measurements. The lepton flavor violating decays of the $Z$ gauge boson were also studied. In the renormalizable scenario, it was found the undetectable branching ratios $BR(Z\to μ^\pm e^\mp)<5.7\times 10^{-21}$ and $BR(Z\to τ^\pm μ^\mp)<2.0\times 10^{-12}$. In the nonrenormalizable scenario, it was found that $BR(Z\to μ^\pm e^\mp)<0.67\times 10^{-12}$ and $BR(Z\to τ^\pm μ^\mp)<1.12\times 10^{-7}$. Although the latter branching ratio is relatively large, it still could not be within the range of future measurements.
description: Updated to essentially match published version
Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
Creators: name: Wang, H.
name: Moore, R.
name: Negishi, M.
name: Omiecinski, C. J.
name: Sueyoshi, T.
name: Zhang, T.-C.
name: LeCluyse, E. L.
name: Faucette, S. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the majority of currently identified CYP3A4 and CYP2B6 inducers are confirmed activators of hPXR but not hCAR. To compare these receptors with respect to their chemical selectivities, 16 drugs known to induce CYP3A4 and/or CYP2B expression were evaluated for relative activation of hPXR versus hCAR. Because of the high basal but low chemical-induced activation of hCAR in immortalized cells, alternative methods were used to evaluate hCAR activation potential. Thirteen of the 16 compounds were classified as moderate to strong hPXR activators. In contrast, carbamazepine (CMZ), efavirenz (EFV), and nevirapine (NVP) were classified as negligible or weak hPXR activators at concentrations associated with efficacious CYP2B6 reporter or endogenous gene induction in primary human hepatocytes, suggesting potential activation of hCAR. Subsequent experiments demonstrated that these three drugs efficiently induced nuclear accumulation of in vivo-transfected enhanced yellow fluorescent protein-hCAR and significantly increased expression of a CYP2B6 reporter gene when hCAR was expressed in CAR−/− mice. In addition, using a recently identified, chemically responsive splice variant of hCAR (hCAR3), the hCAR activation profiles of the 16 compounds were evaluated. By combining results from the hPXR- and hCAR3-based reporter gene assays, these inducers were classified as hPXR, hCAR, or hPXR/hCAR dual activators. Our results demonstrate that CMZ, EFV, and NVP induce CYP2B6 and CYP3A4 preferentially through hCAR and that hCAR3 represents a sensitive tool for in vitro prediction of chemical-mediated human CAR activation.
The ${\cal N} = 8$ Superconformal Bootstrap in Three Dimensions
Creators: name: Chester, Shai M.
name: Lee, Jaehoon
name: Pufu, Silviu S.
name: Yacoby, Ran
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the constraints imposed by unitarity and crossing symmetry on the four-point function of the stress-tensor multiplet of ${\cal N}=8$ superconformal field theories in three dimensions. We first derive the superconformal blocks by analyzing the superconformal Ward identity. Our results imply that the OPE of the primary operator of the stress-tensor multiplet with itself must have parity symmetry. We then analyze the relations between the crossing equations, and we find that these equations are mostly redundant. We implement the independent crossing constraints numerically and find bounds on OPE coefficients and operator dimensions as a function of the stress-tensor central charge. To make contact with known ${\cal N}=8$ superconformal field theories, we compute this central charge in a few particular cases using supersymmetric localization. For limiting values of the central charge, our numerical bounds are nearly saturated by the large $N$ limit of ABJM theory and also by the free $U(1)\times U(1)$ ABJM theory.
description: 74 pages, 7 figures; v2 refs added, minor improvements; v3 typos fixed
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Creators: name: Deutch, A. Y.
name: Duman, R. S.
name: Newton, S. S.
name: Aprille, J. R.
name: Marx, C. E.
name: Mahadik, S. P.
name: Meltzer, H. Y.
name: Lieberman, J. A.
name: Dwyer, D. S.
name: Li, X.-M.
name: Csernansky, J. G.
name: Porter, J. H.
name: Duncan, G. E.
name: Modica-Napolitano, J. S.
name: Bymaster, F. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, anti-psychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article reviews the current literature describing preclinical and clinical studies that evaluate the efficacy of antipsychotic drugs, their mechanism of action and the potential of first- and second-generation antipsychotic drugs to exert effects on cellular processes that may be neuroprotective in schizophrenia. The evidence to date suggests that although all antipsychotic drugs have the ability to reduce psychotic symptoms via D2 receptor antagonism, some antipsychotics may differ in other pharmacological properties and their capacities to mitigate and possibly reverse cellular processes that may underlie the pathophysiology of schizophrenia.
Changes in maternal sleep from pregnancy to postpartum: a meta-analytic review of actigraphy studies
Creators: name: Surtees, Andrew
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: The aim of this project is to provide a retrospective, meta-analytic review of actigraphy studies conducted with mothers that compare sleep before and after the birth of their child. This is a retrospective registratrion
A heuristic description of high-pT hadron production in heavy ion collisions
Creators: name: Nemchik, Jan
name: Pasechnik, Roman
name: Potashnikova, Irina
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Using a simplified model for in-medium dipole evolution accounting for color filtering effects we study production of hadrons at large transverse momenta $p_T$ in heavy ion collisions. In the framework of this model, several important sources of the nuclear suppression observed recently at RHIC and LHC have been analysed. A short production length of the leading hadron $l_p$ causes a strong onset of color transparency effects manifested themselves as a steep rise of the nuclear modification factor $R_{AA}(p_T)$ at large hadron $p_T$'s. A dominance of quarks with higher $l_p$ leads to a weaker suppression at RHIC than the one observed at LHC. In the RHIC kinematic region we include an additional suppression factor steeply falling with $p_T$, which is tightly related to the energy conservation constraints. The latter is irrelevant at LHC up to $p_T\lesssim 70$ GeV while it causes a rather flat $p_T$ dependence of the $R_{AA}(p_T)$ factor at RHIC c.m. energy $\sqrt{s} = 200$ GeV and even an increasing suppression with $p_T$ at $\sqrt{s} = 62$ GeV. The calculations contain only a medium density adjustment, and for an initial time scale $t_0$ = 1 fm we found the energy-dependent maximal values of the transport coefficient, $\hat{q}_0 = 0.7, 1.0$ and 1.3 GeV$^2$/fm corresponding to $\sqrt{s} = 62, 200$ GeV and 2.76 TeV, respectively. We present a broad variety of predictions for the nuclear modification factor and the azimuthal asymmetry which are in a good agreement with available data from experiments at RHIC and LHC.
description: 14 pages, 17 figures; extra clarifications added in Sects. II and III (with additional Figs. 1-6) and in the extended Sect. V B (with additional Fig.11), references added, conclusions unchanged
Stability Analysis on Shingled High-Efficiency BAPV Modules
Creators: name: Wendlandt, Stefan
name: Kammer, Moritz
name: Carrière, Carolyn
name: Alanis, Luis Eduardo
name: Nikitina, Veronika
name: Reinwand, Dirk
Publisher: name: Zenodo
Year: 2022

description: Current BAPV modules are based on p-type PERC solar
 cells, have half-cut cells and realized in glass-backsheet designs.
 However, the next module generation is already in the starting
 blocks. It is characterized by highly efficient solar cells such as ntype
 SHJ or TOPCon, shows high cell-to-module (CTM) values to
 due shingled module interconnection and has been developed
 sustainably in glass-glass design.
 Within the EU funded HighLite project such modules were
 developed and in this study the prototypes were detailed on their
 stability tested. Next to the thermo-mechanical resistance we are
 also focused on the LID, LeTID and PID sensitivity of those
 modules. The outcome of this investigation is development of
 degradation image pattern at the different cell technologies and
 the novel shingling of solar cells. Finally, we will close the paper
 with a risk analysis.
SUSY explanation of the Fermi Galactic Center Excess and its test at LHC Run-II
Creators: name: Cao, Junjie
name: Shang, Liangliang
name: Wu, Peiwen
name: Yang, Jin Min
name: Zhang, Yang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore the explanation of the Fermi Galactic Center Excess (GCE) in the Next-to-Minimal Supersymmetric Standard Model. We systematically consider various experimental constraints including the Dark Matter (DM) relic density, DM direct detection results and indirect searches from dwarf galaxies. We find that, for DM with mass ranging from $30 {\rm GeV}$ to $40 {\rm GeV}$, the GCE can be explained by the annihilation $χχ\to a^\ast \to b \bar{b}$ only when the CP-odd scalar satisfies $m_a \simeq 2 m_χ$, and in order to obtain the measured DM relic density, a sizable $Z$-mediated contribution to DM annihilation must intervene in the early universe. As a result, the higgsino mass $μ$ is upper bounded by about 350 GeV. Detailed Monte Carlo simulations on the $3\ell+ E_T^{miss}$ signal from neutralino/chargino associated production at 14-TeV LHC indicate that the explanation can be mostly (completely) excluded at $95\%$ C.L. with an integrated luminosity of 100(200) fb$^{-1}$. We also discuss the implication of possible large $Z$ coupling to DM for the DM-nucleon spin dependent (SD) scattering cross section, and find that although the current experimental bounds on $σ^{\rm SD}_p$ is less stringent than the spin independent (SI) results, the future XENON-1T and LZ data may be capable of testing most parts of the GCE-favored parameter region.
description: 6 pages, 3 figures
Mean-Reversion and Optimization
Creators: name: Kakushadze, Zura
Publisher: name: arXiv
Year: 2014
Subjects: subject: Portfolio Management (q-fin.PM)
subject: FOS: Economics and business

description: The purpose of these notes is to provide a systematic quantitative framework - in what is intended to be a "pedagogical" fashion - for discussing mean-reversion and optimization. We start with pair trading and add complexity by following the sequence "mean-reversion via demeaning -> regression -> weighted regression -> (constrained) optimization -> factor models". We discuss in detail how to do mean-reversion based on this approach, including common pitfalls encountered in practical applications, such as the difference between maximizing the Sharpe ratio and minimizing an objective function when trading costs are included. We also discuss explicit algorithms for optimization with linear costs, constraints and bounds.
description: 41 pages; a trivial typo corrected
IMPORTANCE DE PROGRAMMES DE MISE EN PLACE DE CENTRE D'INCUBATION DES START-UP DANS LE MONDE RURAL. CAS DE LA REGION D'ANALANJIROFO, MADAGASCAR
Creators: name: RANDRIALAHAMADY Solo Nirina
name: RAJAONARY Josa Augustina
name: BEZAFY Paulin
name: RADIMILAHY Manana Asidy
Publisher: name: Zenodo
Year: 2023

description: From classical theory to the present day, the economic importance of business is an area on which most authors agree. The start-up is considered to be the foundation of business creation. As a young, innovative company with high growth potential, often the object of fund-raising, the start-up needs support structures such as incubation centers. Dominated by a young population living mainly in rural areas, Madagascar can align its development policy with the promotion of its start-ups. The aim of this manuscript is to demonstrate the value of popularizing start-up incubation programs in rural areas. To this end, we conducted interviews with 120 start-ups in a region of northeastern Madagascar. The data collected was processed using SPSS software. Our results show that the majority of business incubation centers are concentrated in urban or suburban areas. This prevents rural start-ups from benefiting in turn. A large proportion of rural start-ups (92%), often located in remote areas, fail to take off due to a lack of support in the entrepreneurial environment, despite their innovative projects. Some of them proceed by trial and error, with luck playing a key role in their success. In reality, the country's development model does not effectively take into account endogenous factors such as the promotion of new small businesses. In Madagascar, the rural world is still excluded from many entrepreneurial actions and programs, despite its economic and demographic importance. The issue of poverty in this country is sometimes the result of strategies that are inadequate to the reality of the rural world. The government needs to take advantage of the demographic structure and rurality, by popularizing Malagasy start-up incubation programs.
Search for heavy neutrinos and W bosons with right-handed couplings in proton-proton collisions at sqrt(s) = 8 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for heavy, right-handed neutrinos, N[l] (l = e, mu), and right-handed WR bosons, which arise in the left-right symmetric extensions of the standard model, has been performed by the CMS experiment. The search was based on a sample of two lepton plus two jet events collected in proton-proton collisions at a center-of-mass energy of 8 TeV corresponding to an integrated luminosity of 19.7 inverse femtobarns. For models with strict left-right symmetry, and assuming only one N[l] flavor contributes significantly to the WR decay width, the region in the two-dimensional (M[WR], M[N]) mass plane excluded at a 95% confidence level extends to approximately M[WR] = 3.0 TeV and covers a large range of neutrino masses below the WR boson mass, depending on the value of M[WR]. This search significantly extends the (M[WR], M[N]) exclusion region beyond previous results.
description: Replaced with published version. Added journal reference and DOI