title: Ð¡ÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð¾Ð¹ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð³ÐµÐºÑÑÑÐ¸Ð´Ð¸Ð½Ð° Ð² Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°Ñ Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¸ Ð·Ð°ÑÑÐ±ÐµÐ¶Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Comparison of hexetidine antimicrobial efficiancy in drugs of local and foreign production
Creators: name: ÐÐ»ÑÐºÐ°, ÐÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð³ÐµÐºÑÐµÑÐ¸Ð´Ð¸Ð½
ÑÑÐ»Ð¾Ð²Ð½Ð¾-Ð¿Ð°ÑÐ¾Ð³ÐµÐ½Ð½ÑÐµ Ð¼Ð¸ÐºÑÐ¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ñ
Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
hexetidine
conditionally pathogenic microorganisms
antimicrobial activity

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description: The title of the masterâs dissertation is âHexetidine antimicrobial property comparison between original drug and generic oneâ. The study focused on the comparison between antimicrobial efficiency of hexetidine towards Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger which cause acute respiratory diseases. Comparison was performed with 2 drugs: original one, produced abroad. Generic one, produced locally. Reviewed results of pre-clinical and clinical trials of hexetidine showed high bioavailability and safety for treatment of otolaryngological diseases. It was stated that hexetidine in aerosol form showed higher bioavailability and efficiency. Experimental parts including in this study resulted in comparison analysis of drug formula and evaluation of antimicrobial efficiency of original and generic hexetidine products. In vitro studies confirmed that both products demonstrated high antimicrobial efficiency with label strength 2 mg/ml. But when decreasing strength microorganisms grow inhibition differ under the same conditions. Further study could focus on determination of optimal conditions for hexetidine synthesis to result local active ingredient with high antimicrobial efficiency towards to given above microorganisms. This will allow localizing the full-cycle production of hexetidine and increase the competitiveness of the domestically produced drug.