cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Activation of the Mitogen-Activated Protein Kinase p38 by Human Cytomegalovirus Infection through Two Distinct Pathways: a Novel Mechanism for Activation of p38
Creators: name: Huong, Shu Mei
name: Huang, Eng Shang
name: Johnson, Robert A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Recent evidence indicates activated mitogen-activated protein kinase (MAPK) p38 has a critical function in human cytomegalovirus (HCMV) viral DNA replication in infected human fibroblasts. To elucidate the mechanism of HCMV-mediated p38 activation, we have performed a detailed analysis of p38 activation and the kinases associated with this activation at different times postinfection. We demonstrate that p38 kinase activity is strongly increased following viral infection. Inhibition of this activity significantly inhibited HCMV-induced hyperphosphorylation of pRb and phosphorylation of heat shock protein 27, suggesting that p38 activation is involved in virus-mediated changes in host cell metabolism throughout the course of infection. We then provide evidence that p38 activation is mediated by different mechanisms at early times versus later times of infection. At early times of infection (8 to 14 h postinfection [hpi]), when p38 activation is first observed, no significant activation of the three kinases which can directly phosphorylate p38 (namely, MKK3, MKK6, and MKK4) is detected. Using vectors which express dominant negative proteins, we demonstrate that basal MKK6 kinase activity is necessary for HCMV-mediated p38 activation at these early times of infection (12 hpi). Then, we use ATP depletion to show that at 12 hpi, HCMV inhibits dephosphorylation of activated p38. These two experiments suggest that HCMV activates p38 by inhibition of dephosphorylation of p38. In contrast to early times of infection, at later times of infection (48 to 72 hpi), increased MKK3/6, but not MKK4, activity is observed. These results indicate that at early times of HCMV infection, increased steady-state levels of activated p38 is mediated at least in part by inhibition of dephosphorylation of p38, while at later times of infection p38 activation is due to increased activity of the upstream kinases MKK3 and MKK6. These findings indicate that HCMV has developed multiple mechanisms to ensure activation of the MAPK p38, a kinase critical to viral infection.
Effectiveness of Monetary Policy Transmission Mechanism in an Implicit Inflation Targeting Regime: The Case of Nigeria.
Creators: name: Apanisile, Tolulope Olumuyiwa
name: Akinlo, Anthony Enisan
name: Apanisile, Tolulope Olumuyiwa
name: Akinlo, Anthony Enisan
Publisher: name: Unknown
Year: 2022
Subjects: subject: Public Economics
subject: transmission mechanism
subject: monetary policy
subject: DSGE
subject: inflation targeting
subject: monetary aggregates

description: The study examines the effectiveness of the monetary policy transmission mechanism in Nigeria by estimating a sticky-price DSGE model using the Bayesian estimation approach. This study is important given the implicit inflation targeting framework employed in the implementation of monetary policy in the country. The study employs quarterly data from 2000:1 to 2019:4 to estimate the two main categories of monetary policy frameworks, monetary aggregate and implicit inflation targeting, respectively. Data are sourced from World Development Indicator (online version). Empirical results show that the monetary policy transmission channels are effective in transmitting policy impulses to the economy within this regime. However, the monetary aggregate framework that is made explicit dampens the achievement of this framework. The study, therefore, concludes that inflation targeting should be made explicit in the country in other to reap the benefits embedded in the framework.
A Musandam Arabic text from Lima (Oman)
Creators: name: Bettega, Simone
name: Gasparini, Fabio
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: This paper presents a short unpublished text recorded in the town of Lima, a small settlement located on the eastern shore of the Musandam peninsula (formally an Omani exclave). The text is fully transcribed and glossed, and a discussion follows in which the main phonological and grammatical peculiarities of the informant’s speech are investigated. The analysis confirms the findings of the few existing studies on Musandam Arabic, and adds some previously undocumented features, discussing their possible relations with other dialects of the Gulf Area. In particular, the hypothesis is put forward that some of the traits typically encountered in Musandam Arabic may find their ultimate origin in the southernmost regions of the Arabian Peninsula.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Potentially inappropriate medication use in older patients in 8 Central and Eastern Europe countries participating in the Horizon 2020 EuroAgeism project: a narrative literature review
Creators: name: Brkic, Jovana
name: Fialova, Daniela
name: Reissigova, Jindra
name: Apostoli, Pranvera
name: Bobrova, Veera
name: Capiau, Andreas
name: Drzaic, Margita
name: Gresakova, Silvia
name: Ince, Ilknur
name: Kummer, Ingrid
name: Ozkan, Oznur
name: Puchon, Erik
name: Sesto, Sofija
name: Tachkov, Konstantin
Publisher: name: Zenodo
Year: 2019

description: 48th European Society of Clinical Pharmacy Symposium “The Digital Revolution: Supporting clinical pharmacy through e-health, digital support systems, big data and more.”; 2019 October 23-5; Ljubljana, Slovenia.
Revisiting Poincaré's Theorem on presentations of discontinuous groups via fundamental polyhedra
Creators: name: Jespers, Eric
name: Kiefer, Ann
name: del Río, Ángel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20H10, 30F40

description: We give a new self-contained proof of Poincaré's Polyhedron Theorem on presentations of discontinuous groups of isometries of a Riemann manifold of constant curvature. The proof is not based on the theory of covering spaces, but only makes use of basic geometric concepts. In a sense one hence obtains a proof that is of a more constructive nature than most known proofs.
description: 38 pages
The 5 Apology Languages: The Secret to Healthy Relationships by  on Audiobook New
Creators: name: Boggs
Publisher: name: Zenodo
Year: 2024

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Efficient loading of reduced data ensembles produced at ORNL SNS/HFIR neutron time-of-flight facilities
Creators: name: Godoy, William F
name: Savici, Andrei T
name: Hahn, Steven E
name: Peterson, Peter F
Publisher: name: arXiv
Year: 2021
Subjects: subject: Databases (cs.DB)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: We present algorithmic improvements to the loading operations of certain reduced data ensembles produced from neutron scattering experiments at Oak Ridge National Laboratory (ORNL) facilities. Ensembles from multiple measurements are required to cover a wide range of the phase space of a sample material of interest. They are stored using the standard NeXus schema on individual HDF5 files. This makes it a scalability challenge, as the number of experiments stored increases in a single ensemble file. The present work follows up on our previous efforts on data management algorithms, to address identified input output (I/O) bottlenecks in Mantid, an open-source data analysis framework used across several neutron science facilities around the world. We reuse an in-memory binary-tree metadata index that resembles data access patterns, to provide a scalable search and extraction mechanism. In addition, several memory operations are refactored and optimized for the current common use cases, ranging most frequently from 10 to 180, and up to 360 separate measurement configurations. Results from this work show consistent speed ups in wall-clock time on the Mantid LoadMD routine, ranging from 19\% to 23\% on average, on ORNL production computing systems. The latter depends on the complexity of the targeted instrument-specific data and the system I/O and compute variability for the shared computational resources available to users of ORNL's Spallation Neutron Source (SNS) and the High Flux Isotope Reactor (HFIR) instruments. Nevertheless, we continue to highlight the need for more research to address reduction challenges as experimental data volumes, user time and processing costs increase.
description: 7 pages, 6 figures, 4 tables, The Second International Workshop on Big Data Reduction held with 2021 IEEE International Conference on Big Data
[PDF/Kindle] EL SECRETO DE LAS BEGUINAS descargar gratis
Creators: name: Cowan
Publisher: name: Zenodo
Year: 2024

description: EL SECRETO DE LAS BEGUINAS de PEDRO M. DOMENE

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EL SECRETO DE LAS BEGUINAS

PEDRO M. DOMENE

Número de páginas: 232

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788494205460

Editorial: TRIFALDI

Año de edición: 2016

 

 

 

 

 

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Overview

Situémonos en el siglo XVII, concretamente por los años en que los Tercios españoles de Flandes habían cercado la ciudad de Ostende, y los ánimos de las gentes de los Países Bajos estaban algo alterados porque el asedio duraba ya algunos meses y ninguno de los dos bandos veía un previsible pronto final, ¿de acuerdo? —comenzó la monja su explicación. Dos hermanos, jóvenes investigadores de historia, se proponen indagar las oscuras razones que motivaron el Auto de Fe dictado por la Inquisición contra un beaterio de beguinas (mujeres cristianas que desde el siglo XII ocupan su vida en ayudar a los desamparados) en la ciudad de Brujas a comienzos del siglo XVII, en un momento en el que la ciudad se halla involucrada en el sitio de Ostende, por su proximidad con ésta. Atando cabos y escrutando viejos manuscritos, el mayor de los hermanos cree haber descubierto el secreto que se encierra entre las paredes del Beguinato de Brujas: bajo la sumisa apariencia de las hermanas, que se ocupan en hacer el bien, parece existir un pacto no escrito entre ellas, que será el objeto de esta novela. La narración avanza en paralelo: la investigación y los hechos acaecidos van in crescendo hasta confluir en un final descubrimiento de la trama. Este libro es también el proceso de reconstrucción de unos acontecimientos acaecidos en 1604 y su conversión en una narración apasionante y verosímil.
[Pdf/ePub/Mobi] UNA PEQUEÑA PERSONALIDAD LINDA
Creators: name: Linares
Publisher: name: Zenodo
Year: 2024

description: UNA PEQUEÑA PERSONALIDAD LINDA EBOOK de BERTA GARCÍA FAET

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UNA PEQUEÑA PERSONALIDAD LINDA EBOOK

BERTA GARCÍA FAET

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788433922212

Editorial: LA BELLA VARSOVIA

 

 

 

 

 

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Overview

Una pequeña personalidad linda recoge las canciones de una voz que se aventura: relatos que nos hablan de un yo andarín que sigue adelante. En un mundo de ecos antiguos, pero también desde la actualidad, este yo cantante camina y camina. Bordeando el tópico literario del homo viator —aquí mulier viatrix— sin abrazarlo del todo, Berta García Faet peregrina por universos fantásticos a la búsqueda de una búsqueda; de su acertijo. Después de las obras incluidas en Corazón tradicionalista, y de la experiencia tensionando lenguaje, pensamiento y emoción que proponían La edad de merecer y Los salmos fosforitos, Una pequeña personalidad linda inaugura un nuevo ciclo poético y vital.
The Winds of Change: The Social and Political Cost of Climate Inaction in Central Asia
Creators: name: Ismailov Murod
Publisher: name: Zenodo
Year: 2023

description: Due to various factors, in Central Asia the climate crisis is not receiving as much attention as in other regions. Central Asia is not always in the headlines and does not receive as much media coverage, which makes it more difficult for people to learn about the impacts of climate change. In addition, countries in the region face a range of challenges, such as poverty, political instability, and economic development, which may take priority over addressing the challenges posed by climate change. In addition, Central Asian states have limited financial and institutional resources to invest in climate change mitigation and adaptation. This can make it more difficult for them to receive international attention and support.
Type 2 allostatic load and thyroid function: supplementary information
Creators: name: Dietrich, Johannes W.
name: Hoermann, Rudolf
name: Midgley, John E. M.
name: Bergen, Friederike
name: Müller, Patrick
Publisher: name: Zenodo
Year: 2020
Subjects: subject: thyroid
subject: homeostasis
subject: allostasis
subject: allostatic load
subject: type 2 allostatic load
subject: TSH
subject: SPINA-GT
subject: Jostel's TSH index
subject: NHANES
subject: Cardiovascular risk
subject: Instrumental variable regression
subject: IV regression
subject: post-traumatic stress disorder (PTSD)
subject: https://www.ncbi.nlm.nih.gov/mesh/68013963
subject: https://www.ncbi.nlm.nih.gov/mesh/68052636
subject: https://www.ncbi.nlm.nih.gov/mesh/68013313
subject: https://www.ncbi.nlm.nih.gov/mesh/68013972
subject: https://www.ncbi.nlm.nih.gov/mesh/68013974
subject: https://www.ncbi.nlm.nih.gov/mesh/68014284
subject: https://www.ncbi.nlm.nih.gov/mesh/68013960
subject: https://www.ncbi.nlm.nih.gov/mesh/68016757
subject: https://www.ncbi.nlm.nih.gov/mesh/68001145
subject: https://www.ncbi.nlm.nih.gov/mesh/68017418

description: Supplementary tables, figure and S scripts accompanying the publication "The two faces of Janus: Why thyrotropin as a cardiovascular risk factor may be an ambiguous target." This scripts are compatible with R 3.6 or newer. The SIQALS evaluation script uses original data of the NHANES study, which are available from https://www.cdc.gov/nchs/nhanes/ The following libraries, some of them coming with R, others being available from CRAN, are necessary for execution: MASS foreign visreg SPINA AER.
description: {"references": ["Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, et al. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne) (2016) 7:57. doi: 10.3389/fendo.2016.00057. PubMed PMID: 27375554; PubMed Central PMCID: PMC4899439", "Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, et al. Thyroid Allostasis\u2013Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Frontiers in Endocrinology (2017) 8. doi: 10.3389/fendo.2017.00163"]}
Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis
Creators: name: Lidbury, Brett A.
name: Heise, Mark T.
name: Morrison, Thomas E.
name: Mahalingam, Suresh
name: Whitmore, Alan C.
name: Shabman, Reed S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Mosquito-borne alphaviruses are a significant cause of both encephalitic and arthritic disease in humans worldwide. In contrast to the encephalitic alphaviruses, the pathogenesis of alphavirus-induced arthritic disease is not well understood. Utilizing a mouse model of Ross River virus (RRV) disease, we found that the primary targets of RRV infection are bone, joint, and skeletal muscle tissues of the hind limbs in both outbred CD-1 mice and adult C57BL/6J mice. Moreover, histological analyses demonstrated that RRV infection resulted in severe inflammation of these tissues. Characterization of the inflammatory infiltrate within the skeletal muscle tissue identified inflammatory macrophages, NK cells, and CD4+ and CD8+ T lymphocytes. To determine the contribution of the adaptive immune system, the outcome of RRV-induced disease was examined in C57BL/6J RAG-1−/− mice, which lack functional T and B lymphocytes. RAG-1−/− and wild-type mice developed similar disease signs, infiltration of inflammatory macrophages and NK cells, and muscle pathology, suggesting that the adaptive immune response does not play a critical role in the development of disease. These results establish the mouse model of RRV disease as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.
Non-Sturmian sequences of matrices providing the maximum growth rate of matrix products
Creators: name: Kozyakin, Victor
Publisher: name: arXiv
Year: 2021
Subjects: subject: Rings and Algebras (math.RA)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 93-05, 15A18, 15A60, 65F15

description: In the theory of linear switching systems with discrete time, as in other areas of mathematics, the problem of studying the growth rate of the norms of all possible matrix products $A_{σ_{n}}\cdots A_{σ_{0}}$ with factors from a set of matrices $\mathscr{A}$ arises. So far, only for a relatively small number of classes of matrices $\mathscr{A}$ has it been possible to accurately describe the sequences of matrices that guarantee the maximum rate of increase of the corresponding norms. Moreover, in almost all cases studied theoretically, the index sequences $\{σ_{n}\}$ of matrices maximizing the norms of the corresponding matrix products have been shown to be periodic or so-called Sturmian, which entails a whole set of "good" properties of the sequences $\{A_{σ_{n}}\}$, in particular the existence of a limiting frequency of occurrence of each matrix factor $A_{i}\in\mathscr{A}$ in them. In the paper it is shown that this is not always the case: a class of matrices is defined consisting of two $2\times 2$ matrices, similar to rotations in the plane, in which the sequence $\{A_{σ_{n}}\}$ maximizing the growth rate of the norms $\|A_{σ_{n}}\cdots A_{σ_{0}}\|$ is not Sturmian. All considerations are based on numerical modeling and cannot be considered mathematically rigorous in this part; rather, they should be interpreted as a set of questions for further comprehensive theoretical analysis.
description: 25 pages, 15 figures, 50 bibliography references, 1 Python program listing, added mistakenly omitted link to Hare, Morris and Sidorov's article
The intercalation phase diagram of Mg in V$_2$O$_5$ from first principles
Creators: name: Gautam, Gopalakrishnan Sai
name: Canepa, Pieremanuele
name: Abdellahi, Aziz
name: Urban, Alexander
name: Malik, Rahul
name: Ceder, Gerbrand
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have investigated Mg intercalation into orthorhombic V$_2$O$_5$, one of only three cathodes known to reversibly intercalate Mg ions. By calculating the ground state Mg$_x$V$_2$O$_5$ configurations and by developing a cluster expansion for the configurational disorder in $δ$-V$_2$O$_5$, a full temperature-composition phase diagram is derived. Our calculations indicate an equilibrium phase separating behavior between fully demagnesiated $α$-V$_2$O$_5$ and fully magnesiated $δ$-V$_2$O$_5$, but also motivate the existence of potentially metastable solid solution transformation paths in both phases. We find significantly better mobility for Mg in the $δ$ polymorph suggesting that better performance can be achieved by cycling Mg in the $δ$ phase.
[PDF/Kindle] UNA CORTE DE NIEBLA Y FURIA (UNA CORTE DE ROSAS Y ESPINAS 2) descargar gratis
Creators: name: Hollingsworth
Publisher: name: Zenodo
Year: 2024

description: UNA CORTE DE NIEBLA Y FURIA (UNA CORTE DE ROSAS Y ESPINAS 2) de TIFFANY CALLIGARIS

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UNA CORTE DE NIEBLA Y FURIA (UNA CORTE DE ROSAS Y ESPINAS 2)

TIFFANY CALLIGARIS

Número de páginas: 352

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408170006

Editorial: PLANETA

Año de edición: 2017

 

 

 

 

 

Ebook descargar el archivo epub UNA CORTE DE NIEBLA Y FURIA (UNA CORTE DE ROSAS Y ESPINAS 2) en español de TIFFANY CALLIGARIS MOBI FB2

 

Overview

«La magia de La Bella y la Bestia con la fuerza de George R. R. Martin.» Goodreads

Feyre está destrozada. Y aunque tiene a Tamlin por fin a su lado sano y a salvo, no sabe cómo podrá dejar atrás los recuerdos que la acechan... ni cómo mantendrá en secreto el oscuro pacto que hizo con Rhysand, que la mantiene intensamente unida a él y la confunde.Feyre ya no puede seguir siendo la de antes. Ahora es fuerte y debe romper con todo lo que la ata. Su corazón necesita libertad.La seducción, el romance y la acción, alcanzan niveles épicos en esta nueva entrega de la saga superventas de Sarah J. Maas.

 «Hermosa y romántica a la vez que salvaje. Absolutamente fascinante» New Yok Times
School Governance and Primary Education Learning Outcomes in Uganda
Creators: name: Nabiddo, Winnie
name: Yawe, Bruno L.
name: Wasswa, Francis
name: Nabiddo, Winnie
name: Yawe, Bruno L.
name: Wasswa, Francis
Publisher: name: Unknown
Year: 2022
Subjects: subject: Public Economics
subject: primary education
subject: outcomes
subject: logit
subject: governance
subject: Uganda

description: While Uganda has implemented several education policies and programmes, learning outcomes at the primary education level remain dismal and below the national development targets. At the same time, household education spending has been growing despite the diverse income inequalities across regions, which continues to impede better learning outcomes at the Primary level. This paper, therefore, examines the determinants of learning outcomes in primary education (in grades three and six) with a specific focus on school governance and community factors. This study has employed a logit model that utilises regional dummies by time-fixed effects and clustering using school-specific registration numbers to deal with unobserved heterogeneity. Our study finds that faith-founded schools, the frequency of school inspections, pupil age, gender, school type (day or boarding), school location, region, frequency of School Management Committees (SMC) meetings per term and school ownership significantly determine proficiency in numeracy and literacy at the primary level. Based on the results, the study recommends promoting early school enrollment, prioritising boarding schools in government schools, and strengthening internal controls in schools. The finding of our paper is handy and will inform policy-makers by independently prescribing specific interventions at lower and upper primary.
Offensive language in Chinese Buddhic discipline texts: The anectodal preambles to the precepts
Creators: name: Villani, Paolo
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: Chinese Buddhic writings condemn verbal abuse since their very beginning, but it is the translations of Indic works about vinaya that offer a systematic discussion of the topic. The juxtaposition of passages of various monastic discipline texts shows slight yet not unimportant differences concerning both the worrisome details causing the Buddha to dictate the precepts as well as the parables the Buddha resorts to in founding the censure of offensive language.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Va tuje darvɑzeǃ Di Maria has been a pest all night: Evaluative language in Persian and English live football commentary
Creators: name: Hassanvandi, Samir
name: Golchinnezhad, Maryam
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: This paper explores the expression of evaluative language in live football commentary in Persian and English. The main focus of this study was to explore differences in the use of evaluation in three different modes of football live commentary provided in the UEFA Champions League (UCL) 2014 final match between Real Madrid and Atlético Madrid: live radio commentary (LRC), live TV commentary (LTVC), and live text commentary (LTC). The expressions of evaluative language were analyzed regarding Attitude. Attitude is one of three central components of the appraisal theory (Martin and White, 2005) in language, which is concerned with the use of evaluative language. The study showed that attitudinal resources were prevalent and varied in the extracts analyzed. They were mainly Judgment oriented and negative. The case study was an attempt to contribute to this growing area of research by exploring the live football commentary genre. The mode of live commentary had a crucial role in determining the number of words spoken during the commentary. Also, the commentator’s biased opinion was undeniable, especially in the polarity of the evaluative expressions they used. In each commentary, by nature, there was a predominantly focus on product or process. In LTC, since the commentator is watching the finished action, the focus is entirely product-oriented. LTC also has more frequent use of Affect resources due to the fact that Affect in general deals with evaluating objects and products or how products and performances are valued. In the other two modes of commentaries, given that the commentators are reporting the events happening in the game in real-time and in the spur of moment, the focus is mostly on the process.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)
Acute Infection with Venezuelan Equine Encephalitis Virus Replicon Particles Catalyzes a Systemic Antiviral State and Protects from Lethal Virus Challenge
Creators: name: Thompson, Joseph M.
name: Johnston, Robert E.
name: Konopka, Jennifer L.
name: Whitmore, Alan C.
name: Webb, Drue L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The host innate immune response provides a critical first line of defense against invading pathogens, inducing an antiviral state to impede the spread of infection. While numerous studies have documented antiviral responses within actively infected tissues, few have described the earliest innate response induced systemically by infection. Here, utilizing Venezuelan equine encephalitis virus (VEE) replicon particles (VRP) to limit infection to the initially infected cells in vivo, a rapid activation of the antiviral response was demonstrated not only within the murine draining lymph node, where replication was confined, but also within distal tissues. In the liver and brain, expression of interferon-stimulated genes was detected by 1 to 3 h following VRP footpad inoculation, reaching peak expression of >100-fold over that in mock-infected animals. Moreover, mice receiving a VRP footpad inoculation 6, 12, or 24 h prior to an otherwise lethal VEE footpad challenge were completely protected from death, including a drastic reduction in challenge virus titers. VRP pretreatment also provided protection from intranasal VEE challenge and extended the average survival time following intracranial challenge. Signaling through the interferon receptor was necessary for antiviral gene induction and protection from VEE challenge. However, VRP pretreatment failed to protect mice from a heterologous, lethal challenge with vesicular stomatitis virus, yet conferred protection following challenge with influenza virus. Collectively, these results document a rapid modulation of the host innate response within hours of infection, capable of rapidly alerting the entire animal to pathogen invasion and leading to protection from viral disease.
Photoexcitations in the Hubbard model -- generalized Loschmidt amplitude analysis of impact ionization in small clusters
Creators: name: Watzenböck, Clemens
name: Wallerberger, Markus
name: Ruzicka, Laurenz
name: Worm, Paul
name: Held, Karsten
name: Kauch, Anna
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study photoexcitations in small Hubbard clusters of up to 12 sites, some of which show an increase of the double occupation after the electric field pulse through impact ionization. Here, the time-dependent electromagnetic field is introduced through a Peierls substitution and the time evolution is calculated by exact diagonalization with commutator-free Magnus integrators. As a tool to better analyze the out-of-equilibrium dynamics, we generalize the Loschmidt amplitude. This way, we are able to resolve which many-body energy eigenstates are responsible for impact ionization and which show pronounced changes in the double occupation and spin energy. This analysis reveals that the loss of spin energy is of little importance for impact ionization. We further demonstrate that, for one-dimensional chains, the optical conductivity has a characteristic peak structure originating solely from vertex corrections.
description: 21 pages, 16 figures
Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 by Rifujin na Magonote, Shirotaka on Ipad
Creators: name: Escamilla
Publisher: name: Zenodo
Year: 2024

description: Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 by Rifujin na Magonote, Shirotaka

 

 

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Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26

Rifujin na Magonote, Shirotaka

Page: 308

Format: pdf, ePub, mobi, fb2

ISBN: 9798888434352

Publisher: Seven Seas Entertainment

 

Ebook library Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 PDB PDF CHM by Rifujin na Magonote, Shirotaka 9798888434352 English version

Light Novel Volume 26 | Mushoku Tensei Wiki - Fandom Rudeus and his team are confronted with the strongest opponent of all, who possesses the demonic power of being able to regenerate his body over and over again  Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 Read "Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26" by Rifujin na Magonote available from Rakuten Kobo. The final disciple of the Man-God  Series: Classroom of the Elite (Light Novel) IN PRINT THIS MONTH. (03/26) I'm a Wolf, but My Boss is a Sheep! Vol. 4; (03/12) (03/12) Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26; (03/05)  Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 (Paperback) · $15.99 · Other Books in Series. Mushoku Tensei Volume 1 ~ 26 (PDF) | Light Novel - YouTube Mushoku Tensei Jobless Reincarnation | Light Novel | All Volumes Pdf  Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. You are here · Home · Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 (Paperback). Mushoku Tensei: Jobless Reincarnation (Light  Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 (Paperback) · $15.99 · Other Books in Series. Mushoku Tensei: Jobless Reincarnation Vol 26 [NEW] Mushoku Tensei: Jobless Reincarnation Vol 26 Japanese language light novel by Rifujin na Magonote. Mushoku Tensei: Jobless Reincarnation Volume 26 Pdf Feb 1, 2024 — Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 Equipped with Laplace's Fighting God Armor and an unparalleled ability to regenerate his body, Badigadi promises a vicious, no-holds-barred fight to the death  Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 Mushoku Tensei: Jobless Reincarnation (Light Novel) Vol. 26 The final disciple of the Man-God appears alongside the treacherous Geese: Badigadi. Equipped with  Mushoku Tensei: Jobless Reincarnation II Season Reveals 4 days ago — Mushoku Tensei Jobless Reincarnation Novel Volume 26 Mushoku Tensei: Jobless Reincarnation Novel Volume 26 was written by Rifujin Na Magonote with illustrations by Shirotaka.The final disciple of the Man-God
Temporal course of peripheral inflammation markers and indexes following acute ischemic stroke: prediction of mortality, functional outcome, and stroke-associated pneumonia
Creators: name: Adiguzel, Ahmet
name: Arsava, Ethem Murat
name: Topcuoglu, Mehmet Akif
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Complete blood count derived indexes such as lymphocyte-to-neutrophil ratio (NLR) may help in predicting pneumonia and prognosis in acute stroke. However, the optimal time point for using these biomarkers is not known. In 205 consecutive severe (NIHSS>10) acute ischemic stroke patients, daily leukocyte, lymphocyte, neutrophil, monocyte, platelet, albumin, fibrinogen, hematocrit, NLR, PLR (Platelet-to-lymphocyte-ratio), LMR (Lymphocyte-to-monocyte-ratio), and SII (systemic-immune-inflammation-index) were determined. General linear models for repeated measures (GLMR) and receiver operating characteristics [ROC] analyses were conducted to define their daily discriminative ability. GLMR-prognosis modeling documented that the main determinants of significant daily variations of 12 parameters studied were age and 24th-hour-NIHSS. In addition, daily changes of NLR, neutrophil, leukocyte (all increased on day-2 and remained higher) and platelet count (decreased after day-6 and stayed lower) were related significantly to survival status (mortality in 19.5%). Albumin levels (lower after day-2) were marginally associated by functional prognosis (modified-Rankin-Score≤3 in 28%). There was a borderline relationship (p = 0.05) between NLR (between day-1 and day-8) and pneumonia development (in 36%). Useful discrimination capability (95% confidence interval lower limit of area-under-curve of ROC≥0.7) was noted for NLR measured on day-6 for mortality, NLR (for 6 days, from day-3-to-day-7, and day-11) and albumin (for every day except day-11 after day-4) for reasonable prognosis and none for pneumonia development. Inflammatory parameters from peripheral routine blood tests showed significant variations during the first two weeks following stroke, but discriminative capacity of these changes is limited due to confounders such as age and post-treatment clinical stroke severity.
A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas
Creators: name: Sullivan, Ruth
name: Gulley, Margaret L.
name: Jankowska-Gan, Ewa
name: Sun, Xiaoping
name: Burlingham, William J.
name: Young, Ken H.
name: Gumperz, Jenny E.
name: Zhou, Ying
name: Hegde, Subramanya
name: Ma, Shi Dong
name: Tang, Weihua
name: Rajesh, Deepika
name: Kenney, Shannon C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Epstein-Barr virus (EBV) infects cells in latent or lytic forms, but the role of lytic infection in EBV-induced lymphomas is unclear. Here, we have used a new humanized mouse model, in which both human fetal CD34+ hematopoietic stem cells and thymus/liver tissue are transplanted, to compare EBV pathogenesis and lymphoma formation following infection with a lytic replication-defective BZLF1-deleted (Z-KO) virus or a lytically active BZLF1+ control. Both the control and Z-KO viruses established long-term viral latency in all infected animals. The infection appeared well controlled in some animals, but others eventually developed CD20+ diffuse large B cell lymphomas (DLBCL). Animals infected with the control virus developed tumors more frequently than Z-KO virus-infected animals. Specific immune responses against EBV-infected B cells were generated in mice infected with either the control virus or the Z-KO virus. In both cases, forms of viral latency (type I and type IIB) were observed that are less immunogenic than the highly transforming form (type III) commonly found in tumors of immunocompromised hosts, suggesting that immune pressure contributed to the outcome of the infection. These results point to an important role for lytic EBV infection in the development of B cell lymphomas in the context of an active host immune response.
title: La géographie de la santé a-t-elle une place dans l'enseignement en secondaire 1 en cours de géographie-citoyenneté ?
title: état des lieux dans les manuels du canton et propositions de mise en oeuvre
titleType: Subtitle
title: La géographie de la santé a-t-elle une place dans l'enseignement en secondaire 1 en cours de géographie-citoyenneté ?
titleType: AlternativeTitle
Creators: name: Cornaz, Sarah
Publisher: name: Unknown
Year: 0
Subjects: subject: géographie de la santé
subject: citoyenneté
subject: débat
subject: photolangage
subject: droit à l’alimentation
subject: obésité

description: La santé est un sujet primordial qui se doit d’être abordé le plus tôt possible chez l’adulte en devenir. Il est essentiel d’aborder des thèmes comme le surpoids et l’obésité, leurs causes et leurs conséquences, puisqu’ils concernent un adolescent sur quatre au secondaire 1. Peu d’opportunités sont cependant offertes aux enseignants pour les aborder dans le cadre scolaire, à part peut-être dans les cours d’éducation physique ou en cuisine, pour les quelques élèves qui ont accès à cette option. Partant de ce constat, je me suis demandée s’il était possible d’intégrer la santé aux cours de géographie-citoyenneté du secondaire 1. Ma première approche a été l’analyse des manuels de géographie Nathan pour les degrés 9 à 11 Harmos. J’en ai conclu que la santé y était principalement abordée à la négative et dans les pays du Sud uniquement. Il manquait à mon sens un regard croisé afin de comparer les situations vécues dans les pays du Sud avec celles des pays du Nord. L’objectif de ce mémoire professionnel a alors été de construire une séquence dédiée à la santé en me basant sur le thème des droits et des devoirs avec un zoom sur le droit à l’alimentation. Deux activités ont été testées en classe : un photolangage sur le droit à l’alimentation ainsi qu’un débat sur les boissons sucrées. Les conclusions quant à cette séquence d’enseignement sont plutôt prometteuses avec des élèves pour la plupart très intéressés à cette thématique de la santé. Si le photolangage m’a laissé un sentiment mitigé en terme de logistique du côté de l’enseignant et d’implication du côté des élèves, le cours sur la santé et le débat en classe m’ont en revanche convaincue de leur pertinence et me motivent à réitérer cette approche à l’avenir.
Supp File 7 from RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkworm Bombyx mori.
Creators: name: Gajula Gopinath
name: Kuchi Srikeerthana
name: Tomar, Archana
name: Srikakolapu M. Ch. Sekhar
name: Kallare P. Arunkumar
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics

description: This file contains the scripts used for the TMM normalization of the raw read counts and the R-scripts used for the quartile analysis.
Neutral Excitations of Quantum Hall States: a Density Matrix Renormalization Group Study
Creators: name: Kumar, Prashant
name: Haldane, F. D. M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use the dynamical structure factors of the quantum Hall states at $ν=1/3$ and $ν=1/2$ in the lowest Landau level to study their excitation spectrum. Using the density matrix renormalization group in combination with the time-dependent variational principle on an infinite cylinder geometry, we extract the low energy properties. At $ν=1/3$, a sharp magnetoroton mode and the two-roton continuum are present and the finite-size effects can be understood using the fractional charge of the quasi-particle. At $ν=1/2$, we find low energy modes with linear dispersion and the static structure factor $\bar s(q) \sim (q\ell)^3$ in the limit $q\ell \rightarrow 0$. The properties of these modes agree quantitatively with the predictions of the composite-fermion theory placed on the infinite cylinder.
description: 16 pages, 11 figures. Added subfigure 7c and some minor revisions
Inefficient Vaginal Transmission of Tenofovir-Resistant HIV-1
Creators: name: Garcia, J. Victor
name: Swanson, Michael D.
name: Chateau, Morgan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Transmission of drug-resistant HIV has been postulated to be a threat to current first-line antiretroviral therapy (ART) regimens and the efficacy of several antiretroviral-based preexposure prophylaxis (PrEP) strategies being tested. Here we evaluated the effect of the common tenofovir (TFV) resistance mutation K65R on vaginal HIV transmission. Our results demonstrate that despite no overt loss of overall replication competence in vivo, this mutation results in significantly reduced mucosal transmission. When transmitted, the mutant virus eventually reverted to the wild type in 2 of 3 animals examined.
Mensural classifiers and traditional measuring tools used in Acehnese (Indonesia)
Creators: name: Aziz, Zulfadli A.
name: Yusuf, Yunisrina Qismullah
name: Hanifa, Dini
name: Harun, Mohammad
Publisher: name: Kervan. International Journal of African and Asian Studies
Year: 2022

description: This study investigates the mensural classifiers along with various traditional measurement tools used by the Acehnese community in Pidie Jaya District, Aceh Province, Indonesia. The data for this qualitative research with an ethnographic approach was obtained from five sub-districts in Pidie Jaya District. Elicitation techniques and non-participant observation techniques were employed to collect data from 12 selected informants. Pictures of these tools were taken for documentation. It was found that there are 21 mensural classifiers for the volume measurement unit (kai, sukèe, ndhie, siblakai, cupak, arè, gantang, pacôk, kulah, naléh, gunca, kuyan, tayeun, gaca siarè, gaca sicupak, gaca sikai, glok, cawan, mok, cinu, and tima), one mensural classifier for width measurement unit (naléh) and three mensural classifiers for weight measurement unit (manyam, bungkai, and katoe). These traditional measuring tools are made from parts of plants, recycled goods, and even items sold in the market but are considered traditional by the community, as well as antiques that are believed to have originated from abroad. It is expected that the results of this research can be used as documentation of the Acehnese traditional heritage as an effort to preserve a regional culture in Indonesia. Future research on this topic should also investigate traditional measuring tools that use parts of the human body as measurements because they also exist in Acehnese society.
description: Kervan. International Journal of African and Asian Studies, V. 26 N. 1 (2022): Kervan 26 (2022)