cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Topological phase for entangled two-qubit states
Creators: name: Milman, P.
name: Mosseri, R.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present an unambiguous characterization of the rotation group SO(3) biconnectedness topology using two-qubit maximally entangled states. We show how to generate cyclic evolutions of these states, which are in one-to-one correspondence to closed paths in SO(3). The difference between the well known two classes of such paths translates into the gain of a global phase of $π$ for one class and no phase change for the other. We propose a simple quantum optics interference experiment to demonstrate this topological phase shift.
description: 2 figures
Enablers of and barriers to perinatal mental healthcare access and healthcare provision for refugee and asylum-seeking women in the WHO European region: a scoping review
Creators: name: Markey, Kathleen
name: Moloney, Mairead
name: O’Donnell, Catherine A.
name: Noonan, Maria
name: O’Donnell, Claire
name: Tuohy, Teresa
name: MacFarlane, Anne
name: Huschke, Susann
name: Mohamed, Ahmed Hassan
name: Doody, Owen
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Perinatal mental health is a growing public health concern. Refugee and asylum-seeking women are particularly susceptible to experiencing perinatal mental illness and may encounter a range of challenges in accessing healthcare. This scoping review sought to identify the enablers of and barriers to healthcare access and healthcare provision for refugee and asylum-seeking women experiencing perinatal mental illness in the WHO European Region. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was applied. Nine databases and six grey literature sources were initially searched in April 2022, and an updated search was completed in July 2023. The search identified 16,130 records, and after the removal of duplicates and the screening process, 18 sources of evidence were included in this review. A data extraction table was used to extract significant information from each individual source of evidence, which was then mapped to the seven dimensions of the candidacy framework. Empirical (n = 14; 77.8%) and non-empirical (n = 4; 22.2%) sources of evidence were included. The literature originated from seven countries within the WHO European Region, including the United Kingdom (n = 9; 50%), Germany (n = 3; 16.7%), Denmark (n = 2; 11.2%), Norway (n = 1; 5.6%), Greece (n = 1; 5.6%), Sweden (n = 1; 5.6%), and Switzerland (n = 1; 5.6%). The results indicate that, although enablers and barriers were apparent throughout the seven dimensions of candidacy, barriers and impeding factors were more frequently reported. There was also a notable overall lack of reported enablers at the system level. Unaddressed language barriers and lack of attention to the diversity in culturally informed perceptions of perinatal mental illness were the main barriers at the individual level (micro-level) to identifying candidacy, navigating healthcare systems, and asserting the need for care. The lack of culturally appropriate alignment of healthcare services was the key organizational (meso-level) barrier identified. The wider structural and political contexts (macro-level factors), such as lack of funding for consultation time, focus on Western diagnostic and management criteria, and lack of services that adequately respond to the needs of refugee and asylum-seeking women, negatively influenced the operating conditions and wider production of candidacy. It can be concluded that there are multilevel and interconnected complexities influencing access to and provision of perinatal mental healthcare for refugee and asylum-seeking women.
Clinical features of elderly-onset Adult-onset Still’s disease
Creators: name: Maruyama, Akihito
name: Kokuzawa, Ayako
name: Yamauchi, Yusuke
name: Kirino, Yohei
name: Nagai, Hideto
name: Inoue, Yasushi
name: Ota, Toshiyuki
name: Chifu, Yutaka
name: Inokuchi, Satomi
name: Syuichi Koarada
name: Akihide Ohta
name: Iwamoto, Masahiro
name: Tada, Yoshifumi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: To clarify the characteristics of patients with elderly-onset Adult-onset Still’s disease (AOSD). Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups. In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p p = .0011) and disseminated intravascular coagulation (19.1% vs 2.1%, respectively; p = .0004) were more frequent, and serum ferritin levels were higher (median 12,700 ng/ml vs 2526 ng/ml, respectively; p p = .0006 and p = .0023, respectively) and drug-free remission was less frequent (p = .0035) in the elderly-onset group compared with the younger-onset group. Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.
Additional file 5 of An improved bind-n-seq strategy to determine protein-DNA interactions validated using the bacterial transcriptional regulator YipR
Creators: name: An, Shi-Qi
name: Valvano, Miguel
name: Yu, Yan-Hua
name: Webb, Jeremy
name: Campos, Guillermo Lopez
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 5: Table S4. Primers used in Bind-n-seq procedure.
Clinical features of large vessel vasculitis (LVV): Elderly-onset versus young-onset
Creators: name: Morinaka, Satoshi
name: Tsuboi, Hiroto
name: Hagiwara, Shinya
name: Sugita, Toshiki
name: Tabuchi, Daiki
name: Sato, Ryota
name: Taihei Nishiyama
name: Okamoto, Shota
name: Terasaki, Toshihiko
name: Yagishita, Mizuki
name: Takahashi, Hiroyuki
name: Kondo, Yuya
name: Matsumoto, Isao
name: Sumida, Takayuki
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We compared large vessel vasculitis (LVV) clinical features between age groups. We retrospectively examined clinical features and therapies in 41 LVV patients at our hospital from January 2010 to March 2020. We compared two patient groups, elderly (≥50 years) and young (<50 years). Of all patients, 29 were elderly and 12 were young. In the younger group, upper extremity symptoms (p p p p p p p p < .01). LVV clinical features differed between elderly- and young-age-onset groups.
The Food and Agricultural Policy Simulator
Creators: name: Salathe, Larry E.
name: Price, J. Michael
name: Gadson, Kenneth E.
name: Salathe, Larry E.
name: Price, J. Michael
name: Gadson, Kenneth E.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Agricultural and Food Policy
subject: Research and Development/Tech Change/Emerging Technologies
subject: Agriculture
subject: crops
subject: econometric model
subject: feed grams
subject: livestock
subject: policy analysis

description: This article describes the structure and dynamic properties of the Food and Agricultural Policy Simulator (FAPSIM), an annual econometric model of the US agricultural sector F APSIM estimates a simultaneous price-quantity equilibrium solution for a set of individual commodity models developed for beef, pork, dairy, chickens, eggs, turkeys, corn, oats, barley, gram sorghum, wheat, soybeans, and cotton F APSIM also endogenously determines farm production expenses, cash receipts, net farm Income, Government deficiency and reserve storage payments, consumer price indexes for food products, and farmer participation 10 Government commodity programs The model estimates that each 1OO -million-bushel Increase In corn exports Increases the price of com by $0 15 per bushel
Strong Field Gravitational Lensing by a Kerr Black Hole
Creators: name: Vázquez, Samuel E.
name: Esteban, Ernesto P.
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider a Kerr black hole acting as a gravitational deflector within the geometrical optics, and point source approximations. The Kerr black hole gravitational lens geometry consisting of an observer and a source located far away and placed at arbitrary inclinations with respect to the black hole's equatorial plane is studied in the strong field regime. For this geometry the null geodesics equations of our interest can go around the black hole several times before reaching the observer. Such photon trajectories are written in terms of the angular positions in the observer's sky and therefore become "lens equations". As a consequence, we found for any image a simple classification scheme based in two integers numbers: the number of turning points in the polar coordinate $θ$, and the number of windings around the black hole's rotation axis. As an application, and to make contact with the literature, we consider a supermassive Kerr black hole at the Galactic center as a gravitational deflector. In this case, we show that our proposed computational scheme works successfully by computing the positions and magnifications of the relativistic images for different source-observer geometries. In fact, it is shown that our general procedure and results for the positions and magnifications of the images off the black hole's equatorial plane, reduce and agree with well known cases found in the literature.
description: ReVTeX, 19 pages, 10 figures and 7 tables. Final version with some grammatical changes to abstract and text (equations left unchanged). Submitted to PRD
Adaptive Expectations, the Exponentially Weighted Forecast, and Optimal Statistical Predictors: A Revisit
Creators: name: Bessler, David A.
name: Bessler, David A.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Agricultural and Food Policy
subject: Research Methods/ Statistical Methods
subject: Adaptive expectations
subject: exponentially weighted forecast
subject: optimal statistical predictor
subject: Nerlovian model

description: Relationships between adaptive expectations, the exponentially weighted moving average, and optimal Univariate statistical predictors are reviewed We show that the behavioral-based adaptive expectations are a subclass of both the exponentially weighted moving average and the (0,1,1) ARIMA model The applicability of the adaptive expectations model to 25 empirical price and quantity series is investigated The adaptive expectations behavior and the optimal statistical forecasts are equivalent for 13 senes-11 on Yields and 2 on prices Numerous price series, while exhibiting the general form o[ the adaptive expectations (a (0,1,1) ARIMA process), did not have a coefficient o[ expectations within the originally hypothesized range The behavior consistent with the model underlying these price series would be trend extrapolation rather than averaging (averaging the most recent observation and Its forecast) Series measured at monthly or quarterly Intervals were not adequately modeled by adaptive expectations or as a (0,1,1) ARIMA process
Non-Parametric Class Completeness Estimators for Collaborative Knowledge Graphs -- The Case of Wikidata
Creators: name: Luggen, Michael
name: Difallah, Djellel
name: Sarasua, Cristina
name: Demartini, Gianluca
name: Cudré-Mauroux, Philippe
Publisher: name: arXiv
Year: 2019
Subjects: subject: Databases (cs.DB)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Collaborative Knowledge Graph platforms allow humans and automated scripts to collaborate in creating, updating and interlinking entities and facts. To ensure both the completeness of the data as well as a uniform coverage of the different topics, it is crucial to identify underrepresented classes in the Knowledge Graph. In this paper, we tackle this problem by developing statistical techniques for class cardinality estimation in collaborative Knowledge Graph platforms. Our method is able to estimate the completeness of a class - as defined by a schema or ontology - hence can be used to answer questions such as "Does the knowledge base have a complete list of all {Beer Brands|Volcanos|Video Game Consoles}?" As a use-case, we focus on Wikidata, which poses unique challenges in terms of the size of its ontology, the number of users actively populating its graph, and its extremely dynamic nature. Our techniques are derived from species estimation and data-management methodologies, and are applied to the case of graphs and collaborative editing. In our empirical evaluation, we observe that i) the number and frequency of unique class instances drastically influence the performance of an estimator, ii) bursts of inserts cause some estimators to overestimate the true size of the class if they are not properly handled, and iii) one can effectively measure the convergence of a class towards its true size by considering the stability of an estimator against the number of available instances.
LINFOMA INTRAOCULAR PRIMÁRIO – CASO CLINICO
Creators: name: Silva, Andreia
name: Fonseca, Cristina
name: Fernandes, Julia
name: Proença, Rui
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2019

description: Introdução: O Linfoma Intraocular Primário é uma neoplasia rara que pode envolver o vítreo, retina, epitélio pigmentar da retina, membrana de Bruch e o nervo ótico. Manifesta-se de forma independente ou associado ao linfoma do sistema nervoso central e frequentemente manifesta-se como uma uveíte posterior de difícil tratamento. Esta forma de linfoma é um dos tumores intraoculares mais desafiantes de se diagnosticar. Caso clinico: Relatamos o caso de um linfoma intraocular primário num doente do sexo masculino de 67 anos cuja manifestação inicial foi uma uveíte posterior unilateral. Foi submetido a tratamento com injeções intravítreas de metotrexato duas vezes por semana durante 1 mês, semanalmente no mês seguinte e mensalmente até perfazer um ano. Discussão: O linfoma intraocular primário é reportado como sendo a síndrome mascarada ocular mais comum. Perante a diversidade de apresentações é difícil fazer o diagnóstico precoce, sendo necessário um elevado índice de suspeição. As recomendações publicadas para o tratamento do linfoma intraocular primário variam no caso de envolvimento exclusivamente ocular. O metotrexato intravítreo tem sido uma das opções mais utilizadas, geralmente administrado num esquema intensivo de indução-consolidação-manutenção. No caso apresentado a quimioterapia IV foi eficaz com complicações oculares mínimas.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 43 N.º 2 (2019)
Asymmetric matter from $B-L$ symmetry breaking
Creators: name: Van Dong, Phung
name: Van Loi, Duong
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The present matter content of our universe may be governed by a $U(1)_{B-L}$ symmetry -- the simplest gauge completion of the seesaw mechanism which produces small neutrino masses. The matter parity results as a residual gauge symmetry, implying dark matter stability. The Higgs field that breaks the $B-L$ charge inflates the early universe successfully and then decays to right-handed neutrinos, which reheats the universe and generates both normal matter and dark matter manifestly.
description: 21 pages; substantially improved with references and figures added; matches published version in EPJC
The Food and Agricultural Policy Simulator: The Dairy-Sector Submodel
Creators: name: Salathe, Larry E.
name: Price, J. Michael
name: Gadson, Kenneth E.
name: Salathe, Larry E.
name: Price, J. Michael
name: Gadson, Kenneth E.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Agricultural and Food Policy
subject: Research and Development/Tech Change/Emerging Technologies
subject: Research Methods/ Statistical Methods
subject: Dairy products
subject: econometric model
subject: milk
subject: policy analysis
subject: simulation

description: This article presents the structure, parameters, and validation statistics for the dairy-sector sub-model contained in the U S Department of Agriculture's (USDA's) Food and Agricultural Policy Simulator (FAPSIM) This submodel endogenously estimates dairy cow numbers, milk production farm-level milk prices, fluid milk consumption, and the supply, utilization, and prices of butter, cheese, nonfat dry milk, condensed and evaporated milk, and frozen milk products It also endogenously estimates USDA purchases of manufactured dairy products and the costs of Government dairy product purchases under alternative dairy price-support options The annual model is used to examine the adjustment resulting from lowering dairy price-supports from 75 to 65 percent of the parity
Therapeutic utilization of meditation resources by people with multiple sclerosis: insights from an online patient discussion forum
Creators: name: O’Donnell, Jodi Millicent
name: Jelinek, George Alexander
name: Gray, Kathleen Mary
name: De Livera, Alysha
name: Brown, Chelsea Rae
name: Neate, Sandra Leanne
name: O’Kearney, Emily Louise
name: Keryn Louise Taylor
name: Bevens, William
name: Weiland, Tracey Joy
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 60506 Virology

description: We aimed to describe website traffic and qualitatively analyze an e-health community discussion forum. Participants in this study were people affected by multiple sclerosis visiting the Overcoming Multiple Sclerosis (OMS) website. This mixed methods study combined descriptive analysis of website traffic over 7 years and 1 month, and qualitative analysis of 1 week of posts in the meditation topic, coded into theme groups using qualitative thematic analysis. There were 166 meditation topics posted with 21,530 initial views of primary post and 785 sub-post responses. Meditation posts and sub-posts received 368,713 replies. Number of views increased from 4,684 in 2011 to over 80,000 in 2017, a considerably greater rate of increase than overall traffic. Qualitative analysis of posts on the meditation forum identified themes of barriers and enablers to utilization of meditation resources. Enablement themes dominated, observed across six of the seven theme groups with various forms of positive social and emotional support to learn and practice meditation. One theme, negative emotion, was identified as a barrier. The OMS peer-to-peer patient online discussion forum serves important functions in encouraging, educating and enabling its growing online community. Our analysis may help improve and innovate online support for lifestyle management in many chronic diseases.
Continuous time random walk concepts applied to extended mode coupling theory: A study of the Stokes-Einstein breakdown
Creators: name: Nandi, Manoj Kumar
name: Bhattacharyya, Sarika Maitra
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In an attempt to extend the mode coupling theory (MCT) to lower temperatures, an Unified theory was proposed which within the MCT framework incorporated the activated dynamics via the random first order transition theory (RFOT). Here we show that the theory although successful in describing other properties of supercooled liquids is unable to capture the Stokes-Einstein breakdown. We then show using continuous time random work (CTRW) formalism that the Unified theory is equivalent to a CTRW dynamics in presence of two waiting time distributions. It is known from earlier work on CTRW that in such cases the total dynamics is dominated by the fast motion. This explains the failure of the Unified theory in predicting the SE breakdown as both the structural relaxation and the diffusion process are described by the comparatively fast MCT like dynamics. The study also predicts that other forms of extended MCT will face a similar issue. We next modify the Unified theory by applying the concept of renewal theory, usually used in CTRW models where the distribution has a long tail. According to this theory the first jump given by the persistent time is slower than the subsequent jumps given by the exchange time. We first show that for systems with two waiting time distributions even when both the distributions are exponential the persistent time is larger than the exchange time. We also identify the persistent time with the slower activated process. The extended Unified theory can now explain the SE breakdown. In this extended theory at low temperatures the structural relaxation is described by the activated dynamics whereas the diffusion is primarily determined by the MCT like dynamics leading to a decoupling between them. We also calculate a dynamic lengthscale from the wavenumber dependence of the relaxation time. We find that this dynamic length scale grows faster than the static length scale.
RR Lyrae stars in Galactic globular clusters.III. Pulsational predictions for metal content Z=0.0001 to Z=0.006
Creators: name: M., Di Criscienzo
name: Marconi, M.
name: Caputo, F.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The results of nonlinear, convective models of RR Lyrae pulsators with metal content Z=0.0001 to 0.006 are discussed and several predicted relations connecting pulsational (period and amplitude of pulsation) and evolutionary parameters (mass, absolute magnitude and color of the pulsator) are derived. These relations, when linked with the average mass of RR Lyrae stars, as suggested by horizontal branch evolutionary models, provide a ``pulsational'' route to the determination of the distance modulus, both apparent and intrinsic, of RR Lyrae rich globular clusters. Based on a preliminary set of synthetic horizontal branch simulations, we compare the predicted relations with observed variables in selected globular clusters (M2, M3, M5, M15, M55, M68, NGC 1851, NGC 3201, NGC 5466, NGC 6362, NGC 6934 and IC 4499). We show that the distance moduli inferred by the various theoretical relations are mutually consistent within the errors, provided that the value of the mixing-length parameter slightly increases from the blue to the red edge of the pulsation region. Moreover, we show that the relative ``pulsational'' distance moduli fit well previous empirical results and that the parallax of the prototype variable RR Lyr, as inferred by the predicted Period-Wasenheit relation, is in close agreement with the HST astrometric measurement.
description: 23 pages, 17 postscript figures, accepted for publication on ApJ
Additional file 1 of A novel KDM5C mutation associated with intellectual disability: molecular mechanisms and clinical implications
Creators: name: Meng, Yunlong
name: Wang, Xinyao
name: Liu, Kangyu
name: Tang, Xingkun
name: Li, Haining
name: Chen, Jianjun
name: Zhong, Zilin
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
title: A multiple scale, function, and type approach to determine and improve Green Infrastructure of urban watersheds
Creators: name: Arthur, Nils
name: Hack, Jochen
Publisher: name: Elsevier
Year: 2022

description: Green Infrastructure (GI) connects different types of green features via various scales, thereby supporting urban biodiversity and service provision. This study presents a methodology capable of identifying multiple functions to assess GI in less-developed countries, where such methodologies are lacking. GI was assessed based on a high-resolution land use classification using both landscape metrics and spatial data within an urbanized region of San José, Costa Rica, at different scales (watershed, neighbourhood, object). Results showed highly fragmented green spaces (often <10 ha), typically unable to support high levels of biodiversity, along with a low amount of green space per inhabitant (<7.4 m²) within the watershed. Substantially higher tree cover (x6) and tree density (x5) were found in the greenest neighbourhood in comparison to the least green neighbourhood. Potential areas for new GI in the form of green roofs (4.03 ha), permeable pavement (27.3), and potential retention areas (85.3) were determined. Several green spaces (n = 11) were identified as promising GI sites with the potential to increase provision (18.6 m²/inhabitant). The adopted methodology demonstrates the potential of GI for increasing recreational green space access, runoff reduction, and flood retentions while supporting biodiversity, validating its utility in guiding decision-making and policy generation.
The cluster environments of radio-loud quasars at 0.6 < z < 1.1
Creators: name: Barr, J. M.
name: Bremer, M. N.
name: Baker, J. C.
name: Lehnert, M. D.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have carried out multicolour imaging of a complete sample of radio-loud quasars at 0.6 < z < 1.1 and find groups or clusters of galaxies in the fields of at least 8 and possibly 13 of the 21 sources. There is no evidence for an evolution in the richness of the environments of radio-loud quasars from other low-redshift studies to z >~ 0.9. The quasars associated with groups and clusters in our sample do not necessarily reside in the centre of the galaxy distribution which rarely displays a spherical geometry. Clustering is preferentially associated with small or asymmetric steep-spectrum radio sources. The quasars with the largest projected angular size are, in nearly all cases, found in non-clustered environments. Radio-based selection (including source size) of high-redshift groups and clusters can be a very efficient method of detecting rich environments at these redshifts. We find that in optical searches for galaxy overdensities above z ~ 0.6 multiple filters must be used. If the single-filter counting statistics used by groups at lower redshift are applied to our data, uncertainties are too large to make accurate quantifications of cluster richness. This means that genuine clustering of galaxies about quasars will be missed and, in ~10% of cases, putative clusters turn out to be false detections. The statistics are further diluted by the fact that galaxy overdensities are generally not centred on the quasar.
description: 21 pages, 26 figures, accepted for publication in MNRAS
Olho seco: abordagem terapêutica
Creators: name: Barroso, Andreia Soares
name: Torrão, Luis
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2019

description: Resumo Introdução: O olho seco é uma doença multifatorial onde há inflamação da superfície ocular e aumento da osmolaridade do filme lacrimal, podendo ser classificada com base na etiologia, mecanismos e estadio da doença. É uma doença comum que afeta principalmente o sexo feminino e acarreta elevada morbilidade, sobretudo nas formas graves da doença. Objetivo: O objetivo principal deste trabalho consiste numa revisão bibliográfica das modalidades terapêuticas, de forma a identificar qual o tratamento mais eficaz consoante o estadio da doença. Métodos: Efetuou-se uma revisão de artigos publicados na literatura científica, após seleção criteriosa na PubMed e UpToDate. Resultados: A história clínica é fundamental para o diagnóstico, assim como outros testes que avaliam a superfície ocular e a estabilidade do filme lacrimal. As lágrimas artificiais são o tratamento de primeira linha para olho seco ligeiro a moderado. A higiene palpebral é útil no olho seco por perda evaporativa, mas para estados hipossecretores graves prefere-se uma terapia de conservação de lágrimas. O tratamento anti-inflamatório mostrou benefício terapêutico em todos os estadios da doença, por isso é considerado indispensável ao tratamento. O consumo de ácidos gordos ómega-3 é aconselhável, principalmente em doentes com disfunção meibomiana associada. Conclusões: O tratamento é altamente variável, desde a suplementação única com lágrimas artificiais até a um algoritmo terapêutico complexo. Atualmente várias questões permanecem em aberto quanto à toxicidade a longo prazo e efetividade de alguns regimes terapêuticos. No futuro, a biologia molecular e a genética poderão oferecer um melhor entendimento fisiopatológico da doença, o que ajudará na tomada de decisão clínica.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 43 N.º 1 (2019)
MOESM4 of An improved bind-n-seq strategy to determine protein-DNA interactions validated using the bacterial transcriptional regulator YipR
Creators: name: An, Shi-Qi
name: Valvano, Miguel
name: Yu, Yan-Hua
name: Webb, Jeremy
name: Campos, Guillermo
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 4: Table S3. Barcode assignment for Bind-n-seq.
The challenging approach to a combined neurotrophic and exposure corneal ulcer - A successful case of treatment with an RGTA
Creators: name: Soares Carneiro, Inês
name: M. Neves, Miguel
name: Gomes, Miguel
name: Oliveira, Luis
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2019

description: Aim: To describe a challenging clinical case of a patient with a neurotrophic and exposure corneal ulcer. Case report: A 75-year-old male patient, with history of right eye (RE) limbic stem-cell insuficiency due to complications of recurrent herpetic keratitis, underwent successful limbic stem-cell transplantation in 2008. In 2010, an uneventful penetrating keratoplasty was performed. After a cataract phacoemulsification surgery with intraocular lens implantation done in 2011, best corrected visual acuity was 20/20, and remained stable until 2015. In July 2015, the patient developed right facial nerve palsy and two months later, presented with an extensive central corneal ulcer, with a significant thinning of central stroma, without infection signs, but with an imminent risk of perforation. Treatment with topical ofloxacin and intensive ocular lubrification was started in association with permanent ocular oclusion. Due to lack of any clinical improvement, treatment with RGTA [Poli (carboximetilglucose) sulfate, dextrano T40] was started. After two weeks of treatment, a complete reepithelization and partial stromal filling was observed. Continued monitoring and treatment with artificial tears was maintained, with no recurrence observed. Conclusion: There is an unmet need for a medical therapy that could help corneal neurotrophic ulcers to heal. The presented clinical case shows that the approach of targeting extracellular matrix can be effective in the reepithelialization of neurotrophic and exposure corneal ulcer that do not respond to conventional treatments.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 43 N.º 1 (2019)
Juggling bubbles in square capillaries: an experimental proof of non-pairwise bubble interactions
Creators: name: Ginot, Gaël
name: Höhler, Reinhard
name: Mariot, Sandrine
name: Kraynik, Andy
name: Drenckhan, Wiebke
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: .The physical properties of an ensemble of tightly packed particles like bubbles, drops or solid grains are controlled by their interactions. For the case of bubbles and drops it has recently been shown theoretically and computationally that their interactions cannot generally be represented by pair-wise additive potentials, as is commonly done for simulations of soft grain packings. This has important consequences for the mechanical properties of foams and emulsions, especially for strongly deformed bubbles or droplets well above the jamming point. Here we provide the first experimental confirmation of this prediction by quantifying the interactions between bubbles in simple model foams consisting of trains of equal-volume bubbles confined in square capillaries. The obtained interaction laws agree quantitatively with Surface Evolver simulations and are well described by an analytically derived expression based on the recently developed non-pairwise interaction model of Höhler et al. [Soft Matter, 2017, 13,(7):1371], based on Morse-Witten theory. While all experiments are done at Bond numbers sufficiently low for the hydrostatic pressure variation across one bubble to be negligible, we provide the full analysis taking into account gravity in the appendix for the interested reader. Even though the article focuses on foams, all results directly apply to the case of emulsions.
ERTEKLER HÁM ONIŃ ÁDEBIY JANR SIPATINDA ÚYRENILIWI.
Creators: name: Kamalova, Nigora
Publisher: name: Zenodo
Year: 2025

description: Insan turmısınıń barlıq tarawlarında jedel rawajlanıw biziń dáwirimizge tán. Bunda kóp nárseler  óziniń áhmiyetin joǵaltadı, umitiladi hám kereksiz  na’rseler  qatarina qosiladi. Biraq, kóplegen áwladlar ushın ózgermeytuǵın qádiriyatlar bar. Olardin’ qatarinda  kóp ásirlik tariyxına qaramastan, házirgi dáwirde de óziniń áhmietin hám tárbiyalıq potencialın saqlap qalıwǵa erisken-xaliq ertekleri bar.  Folklorlıq shıǵarmalar janrlıq jaqtan úsh  túrge bólinedi [1,12]. Epikalıq, lirikalıq, dramalıq.
No black hole information puzzle in a relational universe
Creators: name: Gambini, Rodolfo
name: Porto, Rafael
name: Pullin, Jorge
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The introduction of a relational time in quantum gravity naturally implies that pure quantum states evolve into mixed quantum states. We show, using a recently proposed concrete implementation, that the rate at which pure states naturally evolve into mixed ones is faster than that due to collapsing into a black hole that later evaporates. This is rather remarkable since the fundamental mechanism for decoherence is usually very weak. Therefore the ``black hole information puzzle'' is rendered de-facto unobservable.
description: 4 pages, no figures, revtex
Tomografia de Coerência Óptica do Segmento Anterior swept-source na avaliação pós-operatória de doentes com exotropia
Creators: name: Cabral, Diogo Reis
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2019

description: Objetivo: Avaliar a reprodutibilidade da medição da distância limbo-músculo em tomografia de coerência óptica de segmento anterior (OCT-SA) e, seguidamente, correlaciona-la com o tamanho da ansa e sucesso cirúrgico em olhos submetidos a cirurgia de retro-inserção do músculo recto externo por ansa. Métodos: Estudo transversal após amostragem consecutiva entre outubro e dezembro de 2016. Obtenção de scans longitudinais por OCT-SA durante fixação horizontal em indivíduos saudáveis, doentes antes de cirurgia de estrabismo e doentes com exotropia que realizaram retro-inserção por ansa do músculo recto externo há mais de doze meses. A distância limbo-músculo foi medida intra-operatoriamente (compasso cirúrgico) e nas imagens de OCT-SA (interface gráfica do utilizador programada em linguagem Matlab). A reprodutibilidade das medições foi avaliada entre 2 observadores independentes, os valores comparados com a técnica gold-standard e, nos doentes operados, analisada a correlação entre a reinserção muscular e o sucesso cirúrgico. Resultados: Inclusão de 60 doentes (120 olhos) normais; 18 doentes (27 olhos) pré-operatórios e 22 doentes (37 olhos) operados. A medição da distância limbo-inserção muscular demonstrou uma reprodutibilidade global excelente (ICC=0.97). Nos doentes operados, foi identificada a zona de inserção muscular em 21 olhos (57%) e a distância média ao limbo foi de 9.95mm [7.52-13.21mm]. Foi encontrada uma forte correlação entre reinserção normal com o sucesso cirúrgico (r=0.756; p=0.01;) mas não com o tamanho da ansa muscular escolhida (r=0.56; p=0.75). Conclusões: A medição limbo-inserção muscular em OCT-SA tem uma excelente reprodutibilidade. O local da inserção muscular após cirurgia por ansa do músculo recto externo pode estar correlacionada com o sucesso cirúrgico.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 43 N.º 1 (2019)
A New Calibration of Star Formation Rate in Galaxies Based on Polycyclic Aromatic Hydrocarbon Emission
Creators: name: Xie, Yanxia
name: Ho, Luis C.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Polycyclic aromatic hydrocarbon (PAH) emission has long been proposed to be a potential star formation rate indicator, as it arises from the photodissociation region bordering the Strömgren sphere of young, massive stars. We apply a recently developed technique of mid-infrared spectral decomposition to obtain a uniform set of PAH measurements from Spitzer low-resolution spectra of a large sample of star-forming galaxies spanning a wide range in stellar mass ($M_\star \approx 10^6-10^{11.4}\,M_{\odot}$) and star formation rate ($\sim 0.1- 2000\,M_{\odot}\rm\,yr^{-1}$). High-resolution spectra are also analyzed to measure [Ne II] 12.8 $μ$m and [Ne III] 15.6 $μ$m, which effectively trace the Lyman continuum. We present a new relation between PAH luminosity and star formation rate based on the [Ne II] and [Ne III] lines. Calibrations are given for the integrated $5-15$ $μ$m PAH emission, the individual features at 6.2, 7.7, 8.6, and 11.3 $μ$m, as well as several mid-infrared bandpasses sensitive to PAH. We confirm that PAH emission is suppressed in low-mass, dwarf galaxies, and we discuss the possible physical origin of this effect.
description: 16 pages, 5 figures, 2 tables, accepted for publication in ApJ
BIOMARCADORES PRÓ-INFLAMATÓRIOS SISTÉMICOS NO EDEMA MACULAR DIABÉTICO E A RESPOSTA ANÁTOMO-FUNCIONAL AO TRATAMENTO COM ANTI-VEGF
Creators: name: Brito, Pedro Silva
name: Silva, Rufino
name: Costa, Jorge
name: Gomes, Nuno
name: Costa, Sandra
name: Correia-Pinto, Jorge
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2019

description: Objetivos: Estudar o papel de biomarcadores inflamatórios sistémicos, como fatores condicionantes da resposta anátomo-funcional ao tratamento com bevacizumab no edema macular diabético (EMD) Material e métodos: estudo prospectivo que incluiu 30 doentes com EMD, tratados com injecções intravítreas de bevacizumab e com seguimento de 12 meses. Para todos os casos foi obtido um perfil analítico basal contemplando risco cardiovascular, disfunção renal, dislipidémia e controlo glicémico. Pela técnica ELISA, foram estudados os seguintes fatores pró-inflamatórios: VEGF, ICAM-1, MCP1 e TNF-α. Os valores analíticos foram correlacionados com indicadores clínicos e tomográficos durante o seguimento. Resultados: Verificamos melhoria significativa da espessura foveal central (EFC) (525.80±136.80 µm para 363.31±76.10 µm, p<0.001), bem como da acuidade visual (AV) (0.61±0.24 para 0.40±0.19 LogMAR, p<0.001). Estes resultados foram obtidos com uma média de 6.20±1.29 injecções. O valor de proteína C reactiva ultrassensível (PCRus) foi preditivo de decréscimo na EFC ≤ 10%, ao 3º e 6º mês de seguimento (odds ratio 1.86 e 2.11, p=0.023 e p=0.013, respetivamente). O valor médio de EFC ao 6º mês correlacionou-se significativamente com os valores de: PCRus (p=0.026, r=0.406), ICAM1 (p=0.042, r=0.402) e MCP1 (p=0.021, r=0.450). Ao 6º mês verificamos que os casos com EFC < 330 µm apresentavam valores mais baixos de PCRus (1.03±0.99 vs 2.63±1.78, p=0.002) e MCP1 (243,58±46,25 vs 310,61±94,10 p=0.039). Quanto à AV final, verificamos por regressão linear que a AV inicial foi a variável mais preditiva da AV final (p<0.001, r2=0.593). Conclusões: Os indicadores de atividade inflamatória sistémica (PCRus, ICAM1, MCP1) correlacionaram-se de forma negativa com o estado macular, sugerindo um efeito limitante na resposta ao tratamento com bevacizumab. O estudo de biomarcadores pró-inflamatórios poderá ser útil na identificação de casos com resposta fraca ou retardada aos agentes anti-VEGF.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 43 N.º 2 (2019)
Efficacy and safety of apremilast for 3 months in Behçet’s disease: A prospective observational study
Creators: name: Hirahara, Lisa
name: Kirino, Yohei
name: Yutaro Soejima
name: Takeno, Mitsuhiro
name: Takase-Minegishi, Kaoru
name: Yoshimi, Ryusuke
name: Takeuchi, Masaki
name: Mizuki, Nobuhisa
name: Nakajima, Hideaki
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: To determine the real-world short-term efficacy and safety of apremilast for Behçet’s disease (BD). The study included patients who received apremilast for refractory oral ulcers in addition to meeting International Study Group criteria for BD or the revised International Criteria for Behçet’s Disease. To assess the efficacy of apremilast, Behçet’s disease current activity form (BDCAF) and patients’ self-perception of their disease activity were monitored for three months. The disease phenotypes, laboratory data, concomitant medication use, and adverse events were also investigated. Fourteen BD patients were included in the study. Concomitant drug use were as follows: colchicine 92.9%, prednisolone 21.4%, immunosuppressants 28.6%, and tumor-necrosis inhibitor 14.3%. Oral ulcers and BDCAF scores at 3 months showed significant improvement compared to baseline. Adverse events during the study were diarrhea (n = 3, 21.4%), nausea (n = 3, 21.4%), music hallucination (n = 1, 7.1%), and branch retinal vein occlusion (n = 1, 7.1%). Apremilast was discontinued in 1 patient (7.1%) due to nausea. Significant improvement in oral ulcer and BDCAF with apremilast was confirmed in real-world BD patients after 3 months. The combination of colchicine and apremilast appears to be well tolerated in BD in the short-term.
MOESM5 of An improved bind-n-seq strategy to determine protein-DNA interactions validated using the bacterial transcriptional regulator YipR
Creators: name: An, Shi-Qi
name: Valvano, Miguel
name: Yu, Yan-Hua
name: Webb, Jeremy
name: Campos, Guillermo
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 5: Table S4. Primers used in Bind-n-seq procedure.
title: The IAB Job Vacancy Survey: Establishment survey on labour demand and recruitment processes, waves 2000 to 2021 and subsequent quarters 2006 to 2022
Creators: name: Börschlein, Erik-Benjamin
name: Diegmann, André
name: Gürtzgen, Nicole
name: Kubis
name: Pirralha, André
name: Pohlan, Laura
name: Popp, Martin
name: Vetter, Franka
Publisher: name: Research Data Centre (FDZ) of the Federal Employment Agency (BA) in the Institute for Employment Research (IAB)
Year: 2024
Subjects: Establishment survey
job vacancies
recruitment processes

description: Die IAB-Stellenerhebung ist eine quartalsweise durchgeführte und repräsentative Betriebsbefragung über das gesamtwirtschaftliche Stellenangebot sowie Einstellungsprozesse in Deutschland. Die Erhebung ermittelt die Gesamtzahl aller offenen Stellen am Arbeitsmarkt, einschließlich jener Stellen, die nicht der Bundesagentur für Arbeit (BA) gemeldet werden. Das erste Modul des Fragebogens enthält Informationen zur Zahl und Struktur offener Stellen, dem erwarteten künftigen Arbeitskräftebedarf, zur wirtschaftlichen Lage und zur Entwicklung der befragten Betriebe. Das zweite Modul erfragt die betriebliche Einschätzung und Nutzung aktueller arbeitsmarktpolitischer Instrumente sowie den betrieblichen Umgang mit am Arbeitsmarkt benachteiligten Personen. Das dritte Modul enthält Fragen zum letzten Fall einer Neueinstellung und zum letzten Fall eines gescheiterten Rekrutierungsversuchs. Das Forschungsdatenzentrum der Bundesagentur für Arbeit stellt die Datensätze der Befragungswellen ab 2000 mit allen Modulen einschließlich der Quartalsbefragungen für externe Wissenschaftlerinnen und Wissenschaftler bereit
Superconductor-like effects in an AC driven normal Mott-insulating quantum dot array
Creators: name: Kumar, Sanjeev
name: Tripathi, Vikram
Publisher: name: arXiv
Year: 2020
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the current response of an AC driven dissipative Mott insulator system, a normal quantum dot array, using an analytical Keldysh field theory approach. Deep in the Mott insulator regime, the nonequilibrium steady state (NESS) response resembles a resistively shunted Josephson array, with a nonequilibrium Mott insulating to conductor transition as the drive frequency Ω is increased. The diamagnetic component of the NESS in the conducting phase is anomalous, implying negative inductance, strikingly reminiscent of the η-pairing phase of a Josephson array with negative phase stiffness. However in the presence of an additional DC field the signature of supercurrent - Shapiro steps - is completely absent. We interpret these properties as number-phase fluctuation effects shared with Josephson systems rather than superconductivity.
description: 12 pages, 7 figures, revtex-4