title: ÐÐµÐ»ÐºÐ¸ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ PGP 9,5 Ð¸ NGF. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð² Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ðµ Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð° Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ Ð´ÑÑ Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Proteins of nervous regulation PGP 9,5 and NGF. The study of their role in the mechanism of pathogenesis of diseases of the human respiratory system
Creators: name: ÐÑÐºÐ¾Ð²Ð°, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð±ÐµÐ»ÐºÐ¾Ð²ÑÐ¹ Ð³ÐµÐ½Ð½ÑÐ¹ Ð¿ÑÐ¾Ð´ÑÐºÑ 9
5
ÑÐ°ÐºÑÐ¾Ñ ÑÐ¾ÑÑÐ° Ð½ÐµÑÐ²Ð¾Ð²
Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°
ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ¼Ð°
ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°
protein gene product 9
nerve growth factor
granuloma
tuberculoma
tuberculosis activity levels

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÐµÐ»ÐºÐ¸ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ PGP 9,5 Ð¸ NGF. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð² Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ðµ Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð° Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ Ð´ÑÑÐ°ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°Â». ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð°ÑÐ¿ÐµÐºÑÐ¾Ð² Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ, Ð¿ÑÐ¾ÑÐ²Ð»ÑÑÑÐµÐ³Ð¾ÑÑ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð´ÑÑÐ°Ð½Ð¸Ñ. ÐÑÐ¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð° Ð¸Ð·ÑÑÐµÐ½Ð° Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸Â PGP 9,5 (Ð±ÐµÐ»ÐºÐ¾Ð²ÑÐ¹ Ð³ÐµÐ½Ð½ÑÐ¹ Ð¿ÑÐ¾Ð´ÑÐºÑ 9,5) Ð¸ NGF (ÑÐ°ÐºÑÐ¾Ñ ÑÐ¾ÑÑÐ° Ð½ÐµÑÐ²Ð¾Ð²) Ð¾Ñ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÐºÐ°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ°. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾ÐºÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ðµ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð², ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ñ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ñ, ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ¼Ñ Ð¸ Ð¾ÐºÑÑÐ¶Ð°ÑÑÐ¸Ðµ Ð¸Ñ ÑÐºÐ°Ð½Ð¸ Ð»ÐµÐ³ÐºÐ¾Ð³Ð¾, Ð°Ð½ÑÐ¸ÑÐµÐ»Ð°Ð¼Ð¸ Ðº ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ð¼ Ð±ÐµÐ»ÐºÐ°Ð¼. ÐÑÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¼ÐµÐ´Ð¸Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ NGF Ð¿ÑÐ¸ 3-Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð²Ð½ÑÑÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ñ Ð¸ Ð² ÑÑÐµÐ½ÐºÐµ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ¼Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ ÑÑÐ¾Ð²Ð½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ NGF Ð²Ð½ÑÑÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼ Ð¾Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÐºÐ°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ°. ÐÐ¾Ð¼Ð¸Ð¼Ð¾ ÑÑÐ¾Ð³Ð¾, Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¼ÐµÐ´Ð¸Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ PGP 9,5 Ð²Ð½ÑÑÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼ Ð¿ÑÐ¸ Ð¿ÐµÑÐµÑÐ¾Ð´Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ðº ÑÑÐ°Ð´Ð¸Ð¸ ÑÐ°Ð·ÑÐµÑÐµÐ½Ð¸Ñ, ÑÐ¾ ÐµÑÑÑ Ð¿ÑÐ¸ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ.Â ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÑÑÑ Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑÐ¼Ð¸ ÑÑÐ¾Ð²Ð½ÐµÐ¹ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ PGP 9,5 Ð²Ð½ÑÑÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼ Ð¾Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÐºÐ°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ° Ð¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÑÐ¾Ð²Ð½ÐµÐ¹ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² PGP 9,5 Ð¸ NGF Ð² Ð»ÐµÐ³Ð¾ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¼Ð¾Ð¶Ð½Ð¾ Ð² Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¾Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÑÑÑÐ¸Ñ ÐºÑÐ¸ÑÐµÑÐ¸ÐµÐ² Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ.
description: The subject of the graduate qualification work is âProteins of nervous regulation PGP 9,5 and NGF. The study of their role in the mechanism of pathogenesis of diseases of the human respiratory systemâ. This work is devoted to the study of various aspects of granulomatous inflammation manifested in tuberculosis of the respiratory system. During the study, the dependence of the expression of nerve regulation proteins PGP 9,5 (protein gene product 9,5) and NGF (nerve growth factor) on the degree of activity of the tuberculosis process, as well as on the characteristics of granulomatous inflammation and the connective tissue component, was studied. In the course of the study, immunohistochemical staining of histological preparations containing granulomas, tuberculomas and surrounding lung tissues, with antibodies to the corresponding proteins, was carried out. When analyzing the obtained results, an increase in the median value of the relative area of NGF expression was registered at the 3rd degree of activity of the tuberculosis process inside the granuloma and in the tuberculoma wall, and the dependence of the level of NGF expression inside the granulomas on the characteristics of the connective tissue component was demonstrated. An increase in the median value of the relative area of PGP 9,5 expression inside granulomas was also shown during the transition of the disease to the stage of resolution, that is, with a decrease in inflammation.Â The obtained results correlate with the dependence of levels PGP 9,5 expression inside granulomas on the characteristics of the connective tissue component and granulomatous inflammation.Â Thus, the registered changes in the expression levels of PGP 9,5 and NGF proteins in the lung tissues of patients can be used as prognostic and differentiating criteria for tuberculosis in perspective.