cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quality of prescribing in UK care homes : using local data to recommend optimal prescribing strategies
Creators: name: Loganathan, Mathumalar
Publisher: name: Imperial College London
Year: 2012

description: Background: Inappropriate prescribing (IP) for older people is a public health concern worldwide because of its implications for increased healthcare costs and adverse drug events (ADE). Care home residents are particularly prone to IP due to intrinsic (frailty) and extrinsic (governance and management of homes) factors. My PhD focussed on prescribing for this vulnerable population. Methods: I conducted two systematic reviews which were aimed at: 1) establishing an IP-ADE link; and 2) interpreting interventions employed to reduce IP. Additionally, I evaluated the effectiveness of a multidisciplinary intervention in reducing IP in two nursing homes (combined sample size of 143 residents) managed by one general practice. In this multidisciplinary intervention, feedback from both a pharmacist medication review and an audit using STOPP (Screening Tool of Older Person's Prescriptions) which identified potentially inappropriate medication (PIM) and START (Screening Tool to Alert doctors to Right Treatment) which identified potential prescribing omission (PPO) were utilised by two general practitioners (GPs) to make appropriate changes to prescriptions. I compared the pre and post-intervention scores for PIMs and PPOs. Finally, I provided recommendations to improve overall prescribing quality in UK care homes. Main findings: The findings include: 1) Evidence for a correlation between IP and ADE was weak; 2) Interventions involving academic detailing, pharmacist medication review and multidisciplinary team meetings were more successful; 3) After the 13 months study, residents in the post-intervention group were significantly less likely to have been prescribed a PIM (RR 0.52, 95% CI 0.41-0.67) or a PPO (RR 0.58, 95% CI 0.48-0.69) as compared to residents in the pre-group. Factors influencing the number of PIMs and PPOs were number of medications and number of comorbidities respectively; 4) Recommendations for improving prescribing quality were broadly categorised into five areas: future research; legislation and directives; education and training; integrated healthcare services; and information technology. Conclusion: The multidisciplinary pharmacist-GP-researcher intervention is an effective and practical approach to reducing IP for nursing home residents.
Trafficking of monocytes to the peritoneum after abdominal surgery and their role in the development of septic complications.
Creators: name: Bunker, Nicholas
Publisher: name: Imperial College London
Year: 2013

description: Background Peritoneal infection that follows surgery is associated with SIRS and the development of multi-organ dysfunction. It has a high mortality. The dynamics of leucocyte trafficking into the peritoneal cavity and the expression of cytokines in response to either endotoxin or abdominal surgery will effect the development of both local and systemic inflammation. Firstly the leucocyte trafficking in response to intraperitoneal LPS (lipopolysaccharide) is compared to an abdominal incision. Then, using the expression of TNFα on the cell membrane as a marker of pro-inflammatory status, this expression is described in animals undergoing surgery followed by a ‘second hit’ of ip LPS. Finally the ability of these trafficked cells to trigger SIRS leading to pathophysiological effects in the lungs was assessed. Methods C57/B6 mice were exposed to either an intra-peritoneal dose of 20ng LPS or abdominal surgery and the leucocytes identified and counted in both blood and peritoneal lavage fluid by flow cytometry. A two-hit model was devised, abdominal surgery the primary hit and 24 hours later ip LPS the second hit. The expression of TNFα was measured with flow cytometry. Using two intravenous dyes a lung permeability index was created comparing mice primed by surgery and those just receiving LPS. The data was analysed using student t-test and one-way ANOVA as appropriate. Results: The time course of migration was different for the various leucocyte sub-populations in response to both LPS and surgery. There was a significant increase in the expression of membrane bound TNFα on monocytes and macrophages in the two-hit model than with surgery or LPS alone. There was a trend to greater lung permeability in the two-hit group. Conclusions Leucocytes migrate to the peritoneal cavity after surgery and are primed to respond vigorously to a subsequent dose of LPS. This may have effects on lung permeability.
MOESM1 of Synthetic metabolic pathway for the production of 1-alkenes from lignin-derived molecules
Creators: name: Luo, Jin
name: Lehtinen, Tapio
name: Efimova, Elena
name: Santala, Ville
name: Santala, Suvi
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Additional file 1. Additional figures.
A Mimetic Strategy to Engage Voluntary Physical Activity In Interactive Entertainment
Creators: name: Wiratanaya, Andreas
name: Lyons, Michael
Publisher: name: figshare
Year: 2017
Subjects: subject: Applied Computer Science
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: 80103 Computer Graphics
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 80702 Health Informatics
subject: FOS: Media and communications
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111703 Care for Disabled
subject: 111004 Clinical Nursing: Tertiary (Rehabilitative)
subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111711 Health Information Systems (incl. Surveillance)

description: We describe the design and implementation of a vision based interactive entertainment system that makes use of both involuntary and voluntary control paradigms. Unintentional input to the system from a potential viewer is used to drive attention-getting output and encourage the transition to voluntary interactive behaviour. The iMime system consists of a character animation engine based on the interaction metaphor of a mime performer that simulates non-verbal communication strategies, without spoken dialogue, to capture and hold the attention of a viewer. The system was developed in the context of a project studying care of dementia sufferers. Care for a dementia sufferer can place unreasonable demands on the time and attentional resources of their caregivers or family members. Our study contributes to the eventual development of a system aimed at providing relief to dementia caregivers, while at the same time serving as a source of pleasant interactive entertainment for viewers. The work reported here is also aimed at a more general study of the design of interactive entertainment systems involving a mixture of voluntary and involuntary control.
Arbeiten in selbstorganisierten Unternehmensstrukturen: Anforderungen und bedeutsame Kompetenzen
Creators: name: Schenkel, Sandra
Publisher: name: Hochschule für Angewandte Psychologie FHNW
Year: 2022
Subjects: Anforderungen
Holacracy
Kompetenzen
selbstgesteuerte Lernprozesse

description: Agile Modelle wie Holacracy zeichnen sich durch verteilte Führung, hohe Vernetzung und Selbstorganisation aus. Diese Masterarbeit identifiziert zentrale Anforderungen der Arbeit in selbstorganisierten Strukturen und bedeutsame Kompetenzen für die Ebene des Individuums. Ansätze zur Unterstützung selbstgesteuerter Entwicklungsprozesse werden eruiert. Das qualitative Forschungsdesign umfasste eine Dokumentenanalyse, Expert:inneninterviews (n = 3) sowie 15 Leitfadeninterviews, eine Fokusgruppe (n =12) und ein Fokusinterview entlang der Schritte der Critical Incident Technique. Anforderungen mit Bezug zum Handeln und Entscheiden unter hoher Autonomie (Orientierung schaffen & Ziele definieren, Rollenbewusstsein) sowie der Abstimmung und Kommunikation (sich koordinieren und abgleichen, Feedback geben, annehmen, einholen) treten als bedeutsam hervor, ebenso wie verschiedene Facetten von Selbstführungs- und Kommunikationskompetenzen. Die Unterstützung selbstgesteuerter Lernprozesse im Kontext der Selbstorganisation erfordert integrative Ansätze, die sowohl organisationale Freiräume für die gezielte Entwicklung im Arbeitsprozess wie auch geschützte Lernräume ermöglichen.
Post-transcriptional regulation of Estrogen Receptor-α by miR-17-92 interaction and LMTK3 phosphorylation in Breast Cancer
Creators: name: Jacob, Jimmy
Publisher: name: Imperial College London
Year: 2013

description: Estrogen receptor-α (ERα) is expressed in two-thirds of BCs and is a well-known prognostic and predictive marker. For this reason it is one of the most studied proteins in BC. To understand how ERα positive BC develops, it is crucial to investigate both how this protein is regulated and which genes are modulated by it. MicroRNAs (miRNAs) control gene expression post-transcriptionally by interacting through sequence complementarity to their target transcripts. Through a microarray approach, we identified the subset of miRNAs modulated by ERα, that include up-regulation of miRNAs derived from the processing of two paralogous primary (pri-) transcripts, pri-miR-17-92 and pri-miR-106a-363. Characterisation of the miR-17-92 locus confirmed that the ERα target protein c-MYC binds its promoter in an estrogen-dependent manner. These findings indicated that miRNAs derived from these pri-miRNAs (miR-18a, miR-19b and miR-20b) target and down-regulate ERα, whilst a subset of pri-miRNA-derived mature miRNAs inhibit protein translation of the ERα transcriptional p160 co-activator, AIB1. Therefore, different subsets of the miRNAs identified act as part of a negative autoregulatory feedback loop. We observed that levels of pri-miR-17-92 increase earlier than the mature miRNAs derived from it, implicating precursor cleavage modulation after transcription. Pri-mir-17-92 is immediately cleaved by Drosha to pre-miR-18a, indicating that its regulation occurs during the formation of the mature molecule from the precursors. Furthermore, we wanted to explore the new kinases that regulate the ERα activity. Thereby, we performed kinome screening (by RNAi technologies) to determine kinases that regulate ERα in MCF-7 BC cells and identified a novel kinase, LMTK3, which acts as positive regulator of ERα's transcriptional activity. This could be a new therapeutic target and/or a novel biomarker for BC, although further studies are required to validate this. Together, these studies identify new transcriptional and translational factors that regulate ERα expression in BC.
Influence of the reed flow on the intonation of the clarinet
Creators: name: Taillard, Pierre-André
name: Dalmont, Jean-Pierre
name: Guillemain, Philippe
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2012

description: The playing frequency of a reed instrument is generally mainly imposed by the resonator. Nevertheless, numerous other factors have an influence on the playing frequency. Among those, the volume velocity pulsated by the reed must be taken into account in the models as it lowers significantly the playing frequency. At first order, this volume velocity can be taken into account by adding an equivalent volume of about 1.cm3 at the entrance of the pipe. However, the concept of equivalent volume is theoretically only valid for linear vibrations i.e., for the clarinet: the non beating reed regime. In the beating regime, this volume is likely to vary quite a lot with the mouth pressure which can lead to intonation problems. In addition, this volume depends much on the reed opening, but experiments performed with an artificial mouth show that for usual openings (0.3-0.7mm) the intonation remains surprisingly stable. This suggests that the reed and mouthpiece makers know how to control this problem by a well chosen design of the lay. A counter-example is obtained by using a ClaripatchTM especially designed so that intonation is particularly difficult to control.
Robust approaches for performing meta-analysis of genome-wide association studies to identify single nucleotide polymorphisms and copy number variations associated with complex traits
Creators: name: Charoen, Pimphen
Publisher: name: Imperial College London
Year: 2013

description: From 2007, there has been a huge proliferation in the discovery of genetic variants affecting human traits and diseases, achieved largely by the integration of multiple genome-wide association studies (GWAS) via meta-analysis. The principal objective of this thesis is to develop robust approaches for meta-analysis GWAS in order to reduce false positive findings and optimise statistical power. I consider both Single Nucleotide Polymorphism (SNP) and Copy Number Variant (CNV) GWAS. First, to gain background knowledge in GWAS and meta-analysis, I was involved in a large-scale meta-analysis GWAS to identify genetic variants associated with alcohol consumption, as the main statistical analyst. This study provided me with the opportunity to investigate ways of reducing the probability of false positive findings, via quality control procedures. The main discovery from the study was the identification of the Autism susceptibility candidate 2 gene (AUTS2) as associated with alcohol consumption at genome-wide significance. In the alcohol study, different phenotype transformations were applied to the data according to the inclusion or exclusion of non-drinkers, which led to questioning which transformation of skewed continuous phenotypes optimises statistical power in GWAS in general, forming the second major investigation in my thesis. It was shown that while the inverse normal transformation (INT) may not be the preferable choice of transformation in many epidemiological studies where effect sizes are large, its application to non-normal phenotypes in GWAS, where effect sizes are small and the priority is discovery over interpretability, may lead to an increase in the discovery of genetic variants affecting continuous traits. Finally, as knowledge about CNVs has accumulated in recent years, the meta-analysis of GWAS on CNVs has become a natural next step forward in the field. Therefore, I investigated and developed an approach to enable CNV meta-analysis to proceed in a similar way as SNP meta-analyses. This approach was developed into a software package, cnvPipe, which was applied to investigate CNVs associated with height and weight in the meta-analysis setting.
Airtight - Luftdichtheit von neuen Gebäuden
Creators: name: Hall, Monika
Publisher: name: Hochschule für Architektur, Bau und Geomatik FHNW
Year: 2021
Subjects: subject: Luftdichtheit
subject: Blower Door
subject: Leckagen
subject: Infiltration
subject: Undichtheiten
subject: Luftdichtheitsmessung
subject: Luftdichtheit EFH
subject: 690 - Hausbau, Bauhandwerk

description: Das Projekt besteht aus drei Teilen: Durchführung von Luftdichtheitsmessungen an 28 neuen Einfamilienhäusern, einem Workshop «Luftdichtheit» mit Experten sowie thermischen Gebäudesimulationen gekoppelt mit einer zonalen Strömungssimulation. Alle gemessenen Gebäude liegen deutlich unter den Anforderungen der SIA 180 für natürliche und mechanische Lüftung. Die Simulationen an einem Einfamilienhaus zeigen, dass der Heizwärmebedarf mit zunehmender Undichtheit zunimmt. Dies ist eine Folge der grossen Temperaturunterschiede zwischen innen und aussen sowie höheren Windgeschwindigkeiten im Winter. Handlungsbedarf zum Thema Luftdichtheit besteht in der Klärung der Verantwortung für die Planung, Ausführung und Abnahme der Luftdichtheit sowie der Schnittstellenkoordination zwischen den Gewerken.
Pay for performance, inequalities, and diabetes care
Creators: name: Alshamsan, Riyadh
Publisher: name: Imperial College London
Year: 2011

description: Background: The Quality and Outcome Framework (QOF) is a major pay for performance scheme that was introduced in 2004 in the UK. The introduction of QOF is a unique opportunity to evaluate the impact of pay for performance on inequalities and in particular on ethnic inequalities. This thesis examines the impact of QOF on ethnic inequalities and on patients with and without comorbidities in diabetes management. Methods: (1) Interrupted time series analysis of electronic medical record data of diabetes patients registered with 29 family practices in South West London for the years 2000 to 2007. (2) Cross-sectional study to examine the association between ethnicity, concordant and discordant comorbidity status and intermediate outcomes (HbA1c, blood pressure, total cholesterol). Results: The quality of diabetes care, as measured by the QOF indicators, has improved substantially throughout the study period, especially for the process aspect of care. The introduction of QOF was associated with initial additional improvements in systolic blood pressure in white and black patients but this was only sustained in black patients. Initial improvements in diastolic blood pressure in white and in cholesterol in black and white patients were not sustained in the post-QOF period. There was no beneficial impact of QOF on HbA1c in any ethnic group. The presence of ≥2 cardiovascular comorbidities was associated with similar blood pressure control among white and South Asian patients when compared with whites without comorbidity but with worse blood pressure control among black patients. Conclusion: The QOF scheme did not appear to address important inequalities in diabetes management over time. Targeted quality improvement strategies may be required to improve health care in vulnerable populations.
title: Ventral onlay und dorsal inlay Harnröhrenplastik mit Mundschleimhaut bei proximaler Harnröhrenstriktur: Unsere initiale Erfahrung
Creators: name: Arden, C.
name: Klein, T.
name: Wagner, A.
name: Hüttenbrink, C.
name: Pahernik, S.
name: Pandey, A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Verwendung von Mundschleimhaut (MSH) gilt als Goldstandard bei der Behandlung von Harnröhrenstrikturen. Es sind mehrere operative Techniken für die Platzierung des Transplantates beschrieben. Wir präsentieren unsere Erfahrung mit einer kombinierten Plastik aus ventral [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
The Role of DDAH and ADMA in Kidney DIsease
Creators: name: Tomlinson, James
Publisher: name: Imperial College London
Year: 2013

description: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis and elevated plasma levels associate with poor cardiovascular and renal outcomes. The dimethylarginine dimethylaminohydrolase enzymes (DDAHs; 1 and 2) metabolise ADMA. A DDAH1 gene variant associates with higher kidney tissue mRNA expression, lower plasma ADMA but counter-intuitively, a steeper rate of eGFR decline. This indicates that renal DDAH1 activity may be deleterious and circulating ADMA does not necessarily reflect the NO-ADMA balance (or severity of disease) within kidney tissue. This study tests the hypothesis that reduced renal DDAH1 activity protects against the progression of kidney function decline, independent of circulating ADMA. Renal DDAH1 expression predominates within the proximal tubule. A novel proximal tubule-specific DDAH1 knock-out (PTD1KO) mouse was developed, which demonstrated tubule-specific dysregulation of ADMA and NO that was not evident systemically. Phenotyping studies in PTD1KO mice did not identify consistent alterations of urinary biochemistry at baseline or after salt loading, however, proteomic analysis revealed significant alterations of urinary peptides at baseline; including down-regulation of uromodulin and collagen. At 12 weeks following folate renal injury, the PTD1KO mouse exhibited less kidney function decline, collagen deposition and pro-fibrotic gene expression (Col12alpha, TGFbeta and ET-1) than controls. Furthermore, ADMA and DDAH1 inhibition reduced tubular sodium and fluid reabsorption in rat microperfusion studies, although studies in PTD1KO mice failed to reproduce this effect. Finally, in vitro studies using a PT cell line and primary PT culture indicated an inhibitory effect of ADMA upon PT cell proliferation. Consistent with recent human genetic studies, these data provide experimental evidence indicating a reduction of renal tubule DDAH1 activity can protect against progressive kidney fibrosis and function decline, independent of plasma ADMA. This work provides novel insights into the role of the NO-ADMA-DDAH axis within the kidney, particularly the tubule.
MOESM3 of Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production
Creators: name: Shen, Jing
name: Chen, Jun
name: Jensen, Peter
name: Solem, Christian
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 3. Primers used in this study.
MitchondriaEMSegmentation2D
Creators: name: Pape, Constantin
Publisher: name: Zenodo
Year: 2022
Subjects: bioimage.io
bioimage.io:model
unet
mitochondria
electron-microscopy
instance-segmentation
2d

description: Download RDF Package
#Prediction Enhancer for Mitochondrion Segmentation in EM This model was trained to segment mitochondria in EM. It predicts foreground and boundary probabilities. Training The network was trained on data from the VNC dataset and trained using torch_em. Training Data Imaging modality: Electron Microscopy Dimensionality: 2D Source: http://dx.doi.org/10.6084/m9.figshare.856713 Recommended Validation It is recommended to validate the instance segmentation obtained from this model using intersection-over-union. This model can be used in ilastik, deepimageJ or other software that supports the bioimage.io model format. Training Schedule n_epochs: 5 batches_per_epoch: 500 batch_size: 1 loss_function: DiceLoss optimizer: Adam learning_rate: 0.0001 n_train_images: None n_validation_images: None Contact For questions or issues with this models, please reach out by: opening a topic with tags bioimageio and mitchondriaemsegmentation2d on image.sc or creating an issue in https://github.com/constantinpape/torch-em
description: Segmentation of mitochondria in EM images. (Uploaded via https://bioimage.io)
Post chemoradiation re-staging of rectal cancer using MRI
Creators: name: Patel, Uday
Publisher: name: Imperial College London
Year: 2012

description: The role of MRI after preoperative treatment of rectal cancer is unclear. This thesis investigates its diagnostic relevance in patient management. Matching pathology with MR images aimed to characterise post treatment rectal cancer appearances on T2 weighted MRI and verify the proposed MRI tumour regression grading system(mrTRG). Correlation of post-chemoradiation mrTRG, T stage(ymrT), N stage(ymrN) and Circumferential Resection Margin(ymrCRM) with histopathological T stage(ypT), N stage (ypN), and pathological CRM(pCRM) was investigated. These parameters were also compared against survival outcomes. The alternative response assessment methods of tumour volume and length change/RECIST as well as mrTRG and ymrT were evaluated against pathology. The accuracy and reproducibility of MRI parameters in assessing rectal cancer response to neoadjuvant chemotherapy was also investigated. Patients with good response to chemoradiation(assessed by mrTRG) were enrolled into a deferral of surgery trial. Serial MRI-based monitoring enabled evaluation of quantitative imaging methods such as Apparent Diffusion Co-efficient (ADC) measurements in distinguishing tumour vs. complete response. Pathological fibrosis correlated with low signal on MRI, tumour was intermediate signal. mrTRG showed good diagnostic accuracy against ypT&pTRG, ymrT’s diagnostic accuracy was fair but improved when grouped into favourable and unfavourable categories. MRI Length&volume assessment were less consistently related. Negative ymrN and potentially clear ymrCRM correlated well with their respective pathological endpoints. Importantly, mrTRG and ymrCRM involvement predicted survival outcomes. mrTRG showed good diagnostic accuracy against pTRG when assessing neoadjuvant chemotherapy response, ymrT correlated less well. Overall mrTRG and ymrT were the most reproducible parameters. ADC values were significantly lower in patients with tumour vs. complete response with ADC measurement of <1.3X10-3/mm2/sec associated with tumour regrowth in 86% of cases. mrTRG and MRI CRM assessment appear the most important post treatment imaging parameters. Grouped ymrT may also be useful. These parameters could be used by the multidisciplinary team to tailor treatment pre-operatively.
Active plasmonic sources based on graphene and molybdenum disulfide
Creators: name: CHARITH KOHOMBAN WICKRAMA JAYASEKARA
Publisher: name: Monash University
Year: 2017
Subjects: subject: 20502 Lasers and Quantum Electronics
subject: FOS: Physical sciences
subject: 100705 Nanoelectronics
subject: FOS: Nanotechnology
subject: 20503 Nonlinear Optics and Spectroscopy
subject: 100703 Nanobiotechnology

description: This thesis provides a comprehensive analysis of nanolasers based on graphene and molybdenum disulfide. Here, we have proposed novel spaser (i.e. nanolaser) designs and analysed their output and operational characteristics. The knowledge can be used to engineer spasers based on two-dimensional plasmonic materials.
title: Harnröhrenersatz mittels trigonaler Tubularisierung und Implantation eines künstlichen hydraulischen Sphinkter-Systems
Creators: name: Rehder, P.
name: Ahlberg, A.
name: Stühmeier, J.
name: Pedrini, M.
name: Jelisejevas, L.
name: Gulacsi, A.
name: Horninger, W.
name: Kivi, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Der funktionelle Verlust der Urethra mit daraus folgender Harninkontinenz ist eine urologische Herausforderung. Gibt es eine Alternative zur künstlichen Harnableitung? Ziel: Die urethrale Rekonstruktion durch trigonale Tubularisierung mit Implantation eines künstlichen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
MOESM4 of Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production
Creators: name: Shen, Jing
name: Chen, Jun
name: Jensen, Peter
name: Solem, Christian
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 4. The sequences of the codon-optimized DNA fragment containing the pdc, adhB genes, and the C. glutamicum ldhA promoter.
Utopias of reinhabitation: Tidings from the age of terminus
Creators: name: ANNE LOUISE MELANO
Publisher: name: Monash University
Year: 2017
Subjects: Literature

description: Utopia, once the story of hope, now contends with anxiety and grief. This research explores four forms of utopian fiction which reflect on how to inhabit a world living in the shadow of catastrophe. Each imagines “reinhabiting” the earth to heal the rift between the human and other than human world, and to rebuild community within the living systems that surround us.
Additional file 1 of Identification of a robust functional subpathway signature for pancreatic ductal adenocarcinoma by comprehensive and integrated analyses
Creators: name: Wang, Ping
name: Zhang, Chunlong
name: Li, Weidong
name: Zhai, Bo
name: Jiang, Xian
name: Reddy, Shiva
name: Jiang, Hongchi
name: Sun, Xueying
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Descriptive summary of datasets used in the study. Table S2. Genes of the 00982_1 subpathway. Table S3. Predictive power of published gene signatures. Figure S1. Dataset Search strategy in GEO database. Figure S2. Flow diagram of dataset selection strategies. Figure S3. Accumulative predictive abilities of signatures. Figure S4. Genes in the path:00982_1 subpathway. Figure S5. Collision classification for GSE57495 and GSE79668 datasets. Figure S6. Prognostic capacity of path:00982_1 signature for classical subtype. by Moffitt classification. Figure S7. Association of path:00982_1 subpathway with other pathways.
Kunstvermittlung in Transformation. Strategien und Perspektiven für die Erforschung und Entwicklung der Vermittlungsarbeit in Museen und Ausstellungen
Creators: name: (:Unkn) Unknown
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: Vermittlungsarbeit
Aktionsforschung
Theorien der Kunstvermittlung
Forschungspraxis
Teamforschung
Research and Development
Vermittlung von Design
Gegenwartskunst
Museum
Gallery Education

description: Strategien und Perspektiven für die Erforschung und Entwicklung der Vermittlungsarbeit in Museen und Ausstellungen. Dieses Projekt ist eine Kooperation zwischen KunstvermittlerInnen der vier Kunsthochschulen und fünf Museen für zeitgenössische Kunst und Design in der Schweiz. Das erste Ziel des Zusammenschlusses ist, Kunstvermittlung mithilfe der Aktionsforschung als eine kritische und autonome Praxis zu entwickeln und zu erforschen. Die Praxis in Museen soll verändert und verbessert und in Beziehung zu neuen Theorien der Kunstvermittlung gesetzt werden. Zum Zweiten geht es darum, aus dieser Forschungspraxis in Ansätzen ein solides und übertragbares Verfahren für die Erforschung von Vermittlung zu entwickeln. An jeder Hochschule arbeiten die VermittlerInnen mit mindestens einem Museum an den oben genannten Themen, passen sie jeweils an die lokale Situation an, leiten für den Standort relevante Fragestellungen ab und führen situierte Vermittlungsprojekte durch. Die unterschiedlichen Sichtweisen, die entstehen, werden an «Roundtables» mit wissenschaftlicher Begleitung durch Carmen Mörsch ausgetauscht und diskutiert. Die Resultate und der Verlauf der Forschung werden in einer Publikation durch die Vermittlungsprojekte abgebildet, die damit ihre eigene Praxis reflektieren und theoretisieren, und die unterschiedlichen Perspektiven zueinander in Beziehung setzen. So wird die Diskussion über Kunstvermittlung weiter produktiv vorangetrieben. Das Transdisziplinäre in diesem Projekt zeichnet sich dadurch aus, dass innerhalb der Kunstvermittlung eine Forschungsstrategie angewendet wird, die für das Feld neu ist und besonders die normalerweise nicht in die Wissensproduktion involvierten AkteurInnen dieses Berufsfelds berücksichtigt. Mit der Aktionsforschung soll bewusst eine Veränderung in Praxis und Theorie entstehen, die das Berufsfeld stärken und von ähnlichen Positionen abgrenzen kann.
Investigating the use of Hospital Episode Statistics data to measure variation in Performance and Quality in Colorectal Surgery
Creators: name: Burns, Elaine
Publisher: name: Imperial College London
Year: 2012

description: This thesis provides a comprehensive overview of general and subspecialist colorectal surgery in England. It examines variation in provision and outcome of colorectal surgery in structure, process and outcome factors at the patient, consultant team and NHS Trust levels. Finally, this thesis examines the potential role of increasing surgical caseload to reduce any demonstrable variation and improve outcome. To address these questions, current issues in surgical quality as well as the coding accuracy reported in the published literature have been reviewed. Colorectal resection and the more specialised procedure of restorative proctocolectomy were examined from the Hospital Episode Statistics dataset. Novel outcome measures were derived using longitudinal analysis. Regression analysis was used to understand the predictors of process factors and outcome measures. I have defined new outcome measures and demonstrated considerable variation in these new measures and in more traditional accepted measures in both general and subspecialist colorectal surgery from routinely collected datasets. Routinely collected data offer an exciting potential data source for measuring performance and quality. If data accuracy can be assured, measures such as reoperation may be used alongside established measures of quality in a meaningful way to benchmarking performance of surgical providers. The methods described in this thesis can be applied to a broad range of surgical specialties. Though volume may have a role in determining outcome and reducing variation in subspecialist colorectal surgery, it is by no means the panacea to improve quality across all providers in general colorectal care. The impact of volume on outcome in more general colorectal surgery is less clear. Though centralisation is likely to have benefits, further evidence of the optimum way to implement such changes is needed rather than indiscriminately increasing volume across all providers for general colorectal surgical care.
E-Commerce-Report Schweiz 2014: Der Schweizer Onlinehandel aus Anbietersicht
Creators: name: Wölfle, Ralf
name: Leimstoll, Uwe
Publisher: name: Hochschule für Wirtschaft FHNW
Year: 2014
Subjects: subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Der E-Commerce-Report beleuchtet die Entwicklung des B2C-E-Commerce aus Sicht von Schweizer Anbietern. Damit unterscheidet er sich von anderen E-Commerce-Studien, die meist auf Konsumentenbefragungen basieren. Die langfristig angelegte Studienreihe basiert auf jährlich durchgeführten Interviews mit Mitgliedern des E-Commerce Leader Panels Schweiz. Dieses Panel repräsentiert Unternehmen, die in ihrer Branche zu den marktprägenden E-Commerce-Anbietern gehören oder durch herausragende Leistungen, z.B. Innovation, besondere Aufmerksamkeit auf sich gezogen haben. Das 2009 etablierte Panel wurde jährlich um einige neue Mitglieder erweitert. An der im Auftrag von Datatrans durchgeführten Studie 2014 beteiligten sich insgesamt 34 Geschäftsführer oder E-Commerce-Verantwortliche. Mehr Infos unter: www.e-commerce-report.ch
The Improvisational Etude: a Model for Creative Practice
Creators: name: DANIEL FRANCIS SHEEHAN
Publisher: name: Monash University
Year: 2017
Subjects: subject: 190407 Music Performance
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research investigates the adaption and application of the classical piano etude as a tool for improvisational performance practice. The research outlines a five-stage model based on the composition, development and performance of improvisational etudes, incorporating reflection to better understand the processes involved in instrumental practice, and how new skills emerge in real-time performance. Presented in the form of composed scores, recorded performances and an exegesis, this research positions the improvisational etude model as a useful template for practitioners seeking to pursue idiosyncratic outcomes in their practice.
Drinking water salinity and the risk of (pre)eclampsia and gestational hypertension in coastal Bangladesh: impacts of climate change
Creators: name: Khan, Aneire
Publisher: name: Imperial College London
Year: 2012

description: Hypertensive disorders in pregnancy are among the leading causes of death and disabilities in women of child-bearing age in low-income countries. Despite the high burden, the pathophysiology and aetiology of these disorders are poorly understood, making effective prevention difficult. Excessive dietary salt intake is an established risk factor for hypertension, but much less is known about the health effects of water salinity. This epidemiological study investigated the relationship between high salinity in drinking water and the risk of (pre)eclampsia and gestational hypertension among pregnant women in a rural coastal community in Dacope, Bangladesh, where both surface- and groundwater have been affected by severe salinity, exacerbated by the effects of sea-level rise and climate change. The population-based case-control study accrued 202 cases of (pre)eclampsia and gestational hypertension and 1,006 controls. The study showed that women in Dacope were exposed to exceptionally high levels of sodium in their drinking water, and found a significant association with the risk of (pre)eclampsia and gestational hypertension. The risks increased in a dose-response manner for increasing quartiles of sodium concentrations in drinking water (ORs 3.36 [95% CI 2.07 – 5.60], 4.35 [2.61 - 6.94] and 5.40 [3.28 – 8.92]), (p-trend<0.001). The associations persisted after adjusting for multiple potential confounders and in several sensitivity analyses. These findings shed light on a previous observation of high rates of (pre)eclampsia and gestational hypertension in the dry season, when salinity levels in surface and groundwater were higher than in the monsoon season. The study provides an evidence base for creating guidelines on sodium consumption for the prevention of hypertensive disorders in pregnant women and the general population living in coastal areas. Furthermore, the study findings can inform policy makers about the urgent need to find sustainable solutions, for example, by finding alternative sources of drinking water. It is likely that climate change will considerably worsen the current situation, and this adds further impetus to the need for intervention.
DOES THE NOVEL GC ACTIVITY OF IRAK3 AFFECT ITS SIGNALLING?
Creators: name: LUBNA FREIHAT
Publisher: name: Monash University
Year: 2017
Subjects: subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology

description: A novel class of guanylate cyclases have recently been discovered that differ to classical guanylate cyclases. Guanylate cyclases are enzymes that catalyse the formation of cGMP, an important second messenger involved in countless biological processes. IRAK3 is an immune protein which functions to reduce the immune response, therefore acting as an anti-inflammatory protein. IRAK3 was shown to contain a guanylate cyclase centre, therefore it was hypothesised that IRAK3 may produce cGMP. The effect this novel guanylate cyclase centre has on the function of IRAK3 in the innate signalling cascade was investigated. This study demonstrates that the cGMP produced by the guanylate cyclase centre may function to modulate the function of IRAK3 and perhaps other proteins in its vicinity, therefore mediate the immune response.
Additional file 1: of RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease
Creators: name: Du, Pei
name: Gao, Keqin
name: Cao, Yu
name: Yang, Shuang
name: Wang, Yang
name: Guo, Ren
name: Zhao, Ming
name: Jia, Sujie
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Table S1. Primer sequences. (DOCX 14 kb)
Proficiency gain and competency assessment in laparoscopic colorectal surgery
Creators: name: Miskovic, Danilo
Publisher: name: Imperial College London
Year: 2012

description: Aims and objectives: The aim of this thesis was to investigate the proficiency gain curve and competency in laparoscopic colorectal surgery (LCS) for specialist colorectal surgeons. The objectives were (1) to analyse the shortfalls of proficiency gain curve analysis in LCS, (2) to develop methods to describe proficiency gain and competency in LCS and (3) to analyse proficiency gain and competency within the National Training Programme (NTP). Methods: Objective 1: Two systematic reviews and a meta-analysis of current evidence were performed. Objective 2: Semi-structured interviews and a Delphi method were applied to develop proficiency and competency assessment tools and clinical cases were used for validation. A novel observational clinical human reliability analysis (OCHRA) of clinical cases was developed and evaluated. Objective 3: clinical and educational data from the National Training Programme were used for the analysis of proficiency gain and competency using advanced statistical methods. Results: Using clinical data alone is insufficient for the description of proficiency gain and competency. A generic assessment scale (GAS form) and a competency assessment tool (CAT) were developed and validated. A combination of CAT and OCHRA has been shown to be highly sensitive and specific to determine competency. Analysis of clinical and educational data revealed a shortening of the proficiency gain curve using the approach of the NTP without the risk of increased rates adverse outcomes. Conclusion: Tools for proficiency gain and competency assessment of specialist surgeons have been shown to be valid and feasible and are fully implemented in the NTP. Data suggest that a novel technique can be introduced to specialists on a National level using a structured educational approach with safe clinical outcomes.
Integrating immune cell functions and apoptosis-based therapies for the treatment of ovarian cancer
Creators: name: Tuthill, Mark
Publisher: name: Imperial College London
Year: 2013

description: High levels of regulatory T cells (Treg cells) restrict immune responses against cancer cells and are associated with adverse outcomes in patients with ovarian cancer. Treg cell development and function is regulated by the transcription factor Foxp3. Studies into the regulation of Foxp3 may identify therapeutic targets that reduce the suppressive functions of Treg cells and enhance immune responses against cancer cells. Immune cells express TNF-related apoptosis-inducing ligand (TRAIL) which can induce the death of cancer cells, whilst sparing normal tissues. The TRAIL receptor (R) agonistic drug Apo2L/TRAIL/Dulanermin, and the TRAIL-R2-specific antibody, conatumumab (AMG 655), are potential treatments for ovarian cancer. The first part of the study investigated the role of Foxo and Kruppel-like factor 2 (Klf2) transcription factors in the regulation of Foxp3. It was found that the overexpression of Foxo factors promoted TGFβ-mediated induction of Foxp3 expression in activated CD4 T cells. However, the overexpression of Klf2 antagonised the induction of Foxp3 expression by TGFβ and PI3K/Akt/mTOR inhibition. The second part of the study investigated the potential of TRAIL as a treatment for ovarian cancer. Although most primary ovarian cancer cells were resistant to TRAIL-induced apoptosis, the majority could be sensitised to TRAIL by SMAC (second mitochondrial-derived activator of caspases) mimetic treatment or proteasome inhibition. Fcγ Receptors (FcγR) are expressed on immune cells within the ovarian cancer tumour microenvironment. The in vivo agonistic, apoptosis-inducing activity of TRAIL-R2-specific antibodies, such as AMG 655, is dependent on FcγR mediated crosslinking. However, FcγR-expressing immune cells were inefficient at enabling AMG 655-induced apoptosis. It was investigated whether AMG 655 could block recombinant forms of TRAIL and thus prevent immune cells from killing cancer cells. However, potent synergy was found between AMG 655 and Apo2L/TRAIL in killing cancer cells via TRAIL-R2. These results suggest that AMG 655 and Apo2L/TRAIL/dulanermin could be combined with a SMAC mimetic drug or proteasome inhibitor to introduce a highly active TRAIL-R agonistic therapy into the cancer clinic. Therapeutic strategies that target Foxo factors or Klf2 in Treg cells; and those that combine AMG 655 and Apo2L/TRAIL/dulanermin have the potential to lead to improved outcomes in patients with ovarian cancer.
title: Bridging the gap: Heineke-Mikulicz Harnröhrenplastik bei längeren Strikturen
Creators: name: Pedrini, M.
name: Pedrini, M.
name: Jelisejevas, L.
name: Gulacsi, A.
name: Horninger, W.
name: Stühmeier, J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Ziel: Überbrückung längerer Harnröhrenstrikturen durch „non-transsecting-urethroplasty“. Fragestellung: Was ist die sinnvolle Maximalstrikturlänge der Heineke-Mikulicz-Harnröhrenplastik? Methoden: Die „non-transsecting urethroplasty“[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
title: Bayesian Modeling to Generate Maps of Rainfall Forecast Uncertainty for Tropical Cyclones
Creators: name: Smith, Ebone
Publisher: name: University Corporation for Atmospheric Research (UCAR)
Year: 2021

description: Hurricanes have presented grave risks to coastal communities in the U.S. Strong winds, storm surge, flooding, and heavy rainfall have resulted in billions of dollars of damage to homes, infrastructure, and agricultural resources, as well as casualties. Forecast models have been used by meteorologists to predict the hazardous impacts of hurricanes and to develop warning systems for vulnerable communities. To build community resilience in geographically, socially, and economically vulnerable areas, it is critical that scientists gain insight into model rainfall uncertainty patterns to improve public warnings. This study investigated forecast model uncertainty by comparing the North American Mesoscale (NAM) model forecasted total rainfall with the observed rainfall from 2018 and 2019 landfalling tropical cyclones. NAM model forecast errors from 47 tropical storms were calculated and input in a Bayesian model to evaluate how the forecasted precipitation errors varied in 1000 hypothetical rainfall scenarios. Three statistical approaches were used for each of the storms: 1) a distribution analysis of the Bayesian-generated error magnitudes, 2) a comparison of rainfall patterns from the NAM model, Stage IV observations, and scenarios generated by the Bayesian model, and 3) an evaluation of worse-case scenario rainfall events in vulnerable communities. The worse-case storm maps created each generated extreme rainfall values covering different geographical locations with varying social vulnerability levels. Some of the storms had very concentrated regions of rainfall whereas other storms had rainfall more widespread across the U.S. which threatened counties with social vulnerability levels ranging from 'very low' to 'very high'.