title: ÐÐµÐ½ÐµÑÐ°ÑÐ¸Ñ Ð»Ð¸Ð½Ð¸Ð¹ Ð¾ÑÐºÐ»Ð¸ÐºÐ° Ð¿Ð¾ ÐÐ­Ð¢-Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¿Ð¾Ð´ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÐµÐ¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Generation of lines of response from PET images for modeling biologically-guided radiation therapy
Creators: name: ÐÐ¾Ð¿Ð¾Ð², ÐÐ°ÐºÑÐ¸Ð¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ
Ð»ÑÑÐµÐ²Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¿ÑÑ-ÑÐºÐ°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
BgRT
ÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ñ
ÑÑÐµÐ¹ÑÐµÑ
Ð²Ð¸ÑÑÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð»ÐµÑÐµÐ½Ð¸Ñ
Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ñ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
MATLAB
C++
ARMADILLO
Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¸Ðµ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ
software development
radiation therapy
pet scanning
simulation
tracer
virtual treatment planning
test automation
medical imaging

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° Ð´Ð»Ñ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸, Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÑÑÐµÐ³Ð¾ ÐÐ­Ð¢-Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ñ. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð²Ð¾Ð¿ÑÐ¾ÑÑ: ÐÐ²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð² Ð»ÑÑÐµÐ²ÑÑ ÑÐµÑÐ°Ð¿Ð¸Ñ Ð¸ ÐµÐµ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸, Ð²ÐºÐ»ÑÑÐ°Ñ ÑÐµÑÐ¼Ð¸Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ Ð¸ ÑÐµÐ»Ð¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾Ð±Ð·Ð¾Ñ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¿Ð¾Ð´ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÐµÐ¼. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐµÐ¹ÑÐµÑÐ° 18FDG Ð² ÐÐ­Ð¢-ÑÐºÐ°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸, ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐ¾ÑÐµÑÑÑ, Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´ÑÑÐ¸Ðµ Ð² ÐÐ­Ð¢, Ð¸ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð¸Ñ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð°. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ° BgRT Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ°, Ð²ÐºÐ»ÑÑÐ°Ñ ÑÐµÑÑÐ¸Ð¸ ÑÐ¾Ð»ÑÐºÐ¾ Ð´Ð»Ñ Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ. ÐÐ±ÑÑÐ¶Ð´ÐµÐ½Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ñ Ð¼ÐµÐ¶Ð´Ñ Ð½Ð°ÑÑÑÐ½Ð¾Ð¹ Ð¸ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»ÑÐ¼Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ° Ð¸ Ð¸Ñ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ. ÐÑÐ½Ð¾Ð²Ð½Ð¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ ÑÐ´ÐµÐ»ÐµÐ½Ð¾ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° ÐÐ­Ð¢-ÑÐºÐ°Ð½ÐµÑÐ°. ÐÐ¿Ð¸ÑÐ°Ð½Ñ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸, Ð¾Ð±ÑÐ°Ñ ÑÑÑÑÐºÑÑÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐµ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ñ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ ÐµÐ³Ð¾ Ð²ÑÑÐ¾ÐºÑÑ ÑÐ¾ÑÐ½Ð¾ÑÑÑ Ð¸ Ð½Ð°Ð´ÐµÐ¶Ð½Ð¾ÑÑÑ. ÐÐµÑÐ¾Ð´Ð¾Ð»Ð¾Ð³Ð¸Ñ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²ÐºÐ»ÑÑÐ°Ð»Ð° ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¾Ð½Ð½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ñ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸ ÑÐµÐ°Ð»ÑÐ½ÑÑ ÐÐ­Ð¢-ÑÐºÐ°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¹. ÐÑÐµÐ¸Ð¼ÑÑÐµÑÑÐ²Ð° ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° Ð²ÐºÐ»ÑÑÐ°ÑÑ ÑÐ»ÑÑÑÐµÐ½Ð½Ð¾Ðµ ÐºÐ°ÑÐµÑÑÐ²Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸, ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÑÐ¸ÑÐºÐ¾Ð² Ð´Ð»Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¸ ÑÐ¾ÐºÑÐ°ÑÐµÐ½Ð¸Ðµ Ð·Ð°ÑÑÐ°Ñ Ð½Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÑÐµÑÑÐ¾Ð². Ð Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ð¸ Ð¿Ð¾Ð´Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÐ¾Ð³Ð¸ ÑÐ°Ð±Ð¾ÑÑ, Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´Ð°ÑÑÐ¸Ðµ, ÑÑÐ¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° Ð¼Ð¾Ð¶ÐµÑ ÑÑÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾ ÑÐ»ÑÑÑÐ¸ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹, Ð¿Ð¾Ð²ÑÑÐ¸ÑÑ ÐºÐ°ÑÐµÑÑÐ²Ð¾ Ð¸ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÑ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. Ð¡Ð¸Ð¼ÑÐ»ÑÑÐ¾Ñ Ð³Ð¾ÑÐ¾Ð² Ðº Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ Ð² ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÑÑ Ð¿ÑÐ°ÐºÑÐ¸ÐºÑ Ð¸ Ð¸Ð¼ÐµÐµÑ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð» Ð´Ð»Ñ Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸.
description: This work is dedicated to the creation and testing of a simulator for radiation therapy using PET images to improve the accuracy and efficiency of treatment. The following issues were addressed during the study: Introduction to radiation therapy and its main objectives, including terminology and goals, as well as an overview of biologically-guided radiation therapy. The features of using the 18FDG tracer in PET scanning, the physical processes occurring in PET, and the limitations of this method are considered. The features of the BgRT apparatus and the patients treatment process, including imaging-only sessions and delivery sessions, are analyzed. The differences between physical and computer models of the patient and their comparison are discussed. The main focus is on the development of a PET scanner simulator. The development tools, general structure of the program, and developed algorithms are described. The testing results of the simulator demonstrated its high accuracy and reliability. The testing methodology included comparing simulation data with real PET scans. The advantages of the simulator include improved quality of radiation therapy planning, reduced risks for patients, and decreased costs of conducting tests. In conclusion, the results of the work confirm that the use of the simulator can significantly improve the outcomes of cancer treatment, enhance the quality and safety of radiation therapy. The simulator is ready for clinical implementation and has the potential to greatly improve the planning and execution of radiation therapy.