cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DiNAMIC.Duo: detecting somatic DNA copy number differences without a normal reference
Creators: name: Gao, Yan
name: Holt, Jeremiah
name: Hayes, D Neil
name: Choi, Hyo Young
name: Walter, Vonn
name: Zhao, Xiaobei
Publisher: name: Oxford University Press (OUP)
Year: 2022

description: MOTIVATION: Somatic DNA copy number alterations (CNAs) arise in tumor tissue because of underlying genomic instability. Recurrent CNAs that occur in the same genomic region across multiple independent samples are of interest to researchers because they may contain genes that contribute to the cancer phenotype. However, differences in copy number states between cancers are also commonly of interest, for example when comparing tumors with distinct morphologies in the same anatomic location. Current methodologies are limited by their inability to perform direct comparisons of CNAs between tumor cohorts, and thus they cannot formally assess the statistical significance of observed copy number differences or identify regions of the genome where these differences occur. RESULTS: We introduce the DiNAMIC.Duo R package that can be used to identify recurrent CNAs in a single cohort or recurrent copy number differences between two cohorts, including when neither cohort is copy neutral. The package utilizes Python scripts for computational efficiency and provides functionality for producing figures and summary output files. AVAILABILITY AND IMPLEMENTATION: The DiNAMIC.Duo R package is available from CRAN at https://cran.r-project.org/web/packages/DiNAMIC.Duo/index.html. This article uses publicly available data from the Broad Institute TCGA Genome Data Analysis Center, https://doi.org/10.7908/C11G0KM9. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
sj-pdf-2-cpj-10.1177_00099228221145271 – Supplemental material for Efficacy of Biomarkers in Identifying Abnormal Echocardiogram in Multisystem Inflammatory Syndrome in Children
Creators: name: Arora, Rajan
name: Sethuraman, Usha
name: Merolla, David M.
name: Sanil, Yamuna
name: Bharadwaj, Madhumithaa
name: Kannikeswaran, Nirupama
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111403 Paediatrics
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-2-cpj-10.1177_00099228221145271 for Efficacy of Biomarkers in Identifying Abnormal Echocardiogram in Multisystem Inflammatory Syndrome in Children by Rajan Arora, Usha Sethuraman, David M. Merolla, Yamuna Sanil, Madhumithaa Bharadwaj and Nirupama Kannikeswaran in Clinical Pediatrics
Direct arene C-H fluorination with 18F- via organic photoredox catalysis
Creators: name: Wang, Hui
name: Giglio, Benjamin
name: Tay, Nicholas E S
name: Huang, Zeng
name: Li, Zibo
name: Nicewicz, David A
name: Chen, Wei
name: Wang, Mengzhe
name: Wu, Zhanhong
Publisher: name: American Association for the Advancement of Science (AAAS)
Year: 2019

description: Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C-H bonds, which limits advancements in PET radiotracer development. Here, we disclose a mild method for the fluorine-18 (18F)-fluorination of aromatic C-H bonds by an [18F]F- salt via organic photoredox catalysis under blue light illumination. This strategy was applied to the synthesis of a wide range of 18F-labeled arenes and heteroaromatics, including pharmaceutical compounds. These products can serve as diagnostic agents or provide key information about the in vivo fate of the labeled substrates, as showcased in preliminary tracer studies in mice.
sj-docx-6-ldq-10.1177_07319487221145689 – Supplemental material for Teaching Expository Text Management and Proficiency Skills for Comprehension for Students With Language/Learning Disabilities
Creators: name: Hall-Mills, Shannon S.
name: Marante, Leesa M.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-6-ldq-10.1177_07319487221145689 for Teaching Expository Text Management and Proficiency Skills for Comprehension for Students With Language/Learning Disabilities by Shannon S. Hall-Mills and Leesa M. Marante in Learning Disability Quarterly
Qualitative needs assessment for the development of a smart thumb prosthesis
Creators: name: Moltaji, Syena
name: Posa, Stephanie
name: Mayo, Amanda L.
name: Hitzig, Sander L.
name: Baltzer, Heather
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: To critically explore experiences following thumb amputation and delineate elements of an ideal thumb prosthesis from the end user perspective. A qualitative study was undertaken with end user stakeholder groups, which included persons with a thumb amputation, rehabilitation professionals, and prosthetists. Analysis proceeded in line with conventional content analysis. Six patients with traumatic thumb amputation and eight healthcare providers (HCPs) were interviewed. Six themes were identified. The first theme discussed the impact of losing a thumb upon function, occupational activities, and mental wellbeing. The second theme reflected the idiosyncratic nature of thumb amputees, including their goals and nature of injury. The third theme stressed the costs associated with obtaining a thumb prosthesis. The fourth theme explored patient frustration and causes of device abandonment. Theme five summarized opinions on currently available thumb prostheses, and theme seven was the ideal design for a thumb prosthetic, including sensory elements and materials. Representative data from stakeholders mapped the current status of thumb prostheses. Preferences for an ideal thumb prosthesis included a simple, durable design with the ability to oppose, grasp, and sense pressure. Affordable cost and ease of fit emerged as systemic objectives. Provides insight into the experiences of individuals following thumb amputation.Identifies challenges that may lead to prosthetic abandonment so that these can be considered and addressed by rehabilitation professionals.Identifies positive elements and preferred materials in current prosthetics so that rehabilitation professionals may incorporate these more frequently. Provides insight into the experiences of individuals following thumb amputation. Identifies challenges that may lead to prosthetic abandonment so that these can be considered and addressed by rehabilitation professionals. Identifies positive elements and preferred materials in current prosthetics so that rehabilitation professionals may incorporate these more frequently.
Additional file 3 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 3.
Early Signs of Gut Microbiome Aging: Biomarkers of Inflammation, Metabolism, and Macromolecular Damage in Young Adulthood
Creators: name: Aiello, Allison E
name: Dowd, Jennifer B
name: Gaydosh, Lauren
name: Renson, Audrey
name: McQueen, Matthew B
name: Krauter, Kenneth S
name: Harris, Kathleen Mullan
name: Shannahan, Michael
Publisher: name: Oxford University Press (OUP)
Year: 2020

description: Emerging links between gut microbiota and diseases of aging point to possible shared immune, metabolic, and cellular damage mechanisms, operating long before diseases manifest. We conducted 16S rRNA sequencing of fecal samples collected from a subsample (n = 668) of Add Health Wave V, a nationally representative longitudinal study of adults aged 32-42. An overlapping subsample (n = 345) included whole-blood RNA-seq. We examined associations between fecal taxonomic abundances and dried blood spot-based markers of lipid and glucose homeostasis and C-reactive protein (measured in Wave IV), as well as gene expression markers of inflammation, cellular damage, immune cell composition, and transcriptomic age (measured in Wave V), using Bayesian hierarchical models adjusted for potential confounders. We additionally estimated a co-abundance network between inflammation-related genes and bacterial taxa using penalized Gaussian graphical models. Strong and consistent microbiota associations emerged for HbA1c, glucose, C-reactive protein, and principal components of genes upregulated in inflammation, DNA repair, and reactive oxygen species, with Streptococcus infantis, Pseudomonas spp., and Peptoniphilus as major players for each. This pattern was largely echoed (though attenuated) for immunological cell composition gene sets, and only Serratia varied meaningfully by transcriptomic age. Network co-abundance indicated relationships between Prevotella sp., Bacteroides sp., and Ruminococcus sp. and gut immune/metabolic regulatory activity, and Ruminococcus sp, Dialister, and Butyrivibrio crossotus with balance between Th1 and Th2 inflammation. In conclusion, many common associations between microbiota and major physiologic aging mechanisms are evident in early-mid adulthood and suggest avenues for early detection and prevention of accelerated aging.
Constitutive expression of apple endo-POLYGALACTURONASE1 in fruit induces early maturation, alters skin structure and accelerates softening
Creators: name: Gunaseelan, Kularajathevan
name: Schröder, Roswitha
name: Rebstock, Ria
name: Ninan, Annu S.
name: Deng, Cecilia
name: Khanal, Bishnu P.
name: Favre, Laurie
name: Tomes, Sumathi
name: Dragulescu, Monica A.
name: O'Donoghue, Erin M.
name: Hallett, Ian C.
name: Schaffer, Robert J.
name: Knoche, Moritz
name: Brummell, David A.
name: Atkinson, Ross G.
Publisher: name: Oxford [u.a.] : Wiley-Blackwell
Year: 2023
Subjects: subject: cell separation
subject: cell wall
subject: Malus domestica
subject: pectin
subject: transcriptomic analysis
subject: transpiration
subject: Dewey Decimal Classification::500 | Naturwissenschaften::580 | Pflanzen (Botanik)

description: During fruit ripening, polygalacturonases (PGs) are key contributors to the softening process in many species. Apple is a crisp fruit that normally exhibits only minor changes to cell walls and limited fruit softening. Here, we explore the effects of PG overexpression during fruit development using transgenic apple lines overexpressing the ripening-related endo-POLYGALACTURONASE1 gene. MdPG1-overexpressing (PGox) fruit displayed early maturation/ripening with black seeds, conversion of starch to sugars and ethylene production occurring by 80 days after pollination (DAP). PGox fruit exhibited a striking, white-skinned phenotype that was evident from 60 DAP and most likely resulted from increased air spaces and separation of cells in the hypodermis due to degradation of the middle lamellae. Irregularities in the integrity of the epidermis and cuticle were also observed. By 120 DAP, PGox fruit cracked and showed lenticel-associated russeting. Increased cuticular permeability was associated with microcracks in the cuticle around lenticels and was correlated with reduced cortical firmness at all time points and extensive post-harvest water loss from the fruit, resulting in premature shrivelling. Transcriptomic analysis suggested that early maturation was associated with upregulation of genes involved in stress responses, and overexpression of MdPG1 also altered the expression of genes involved in cell wall metabolism (e.g. β-galactosidase, MD15G1221000) and ethylene biosynthesis (e.g. ACC synthase, MD14G1111500). The results show that upregulation of PG not only has dramatic effects on the structure of the fruit outer cell layers, indirectly affecting water status and turgor, but also has unexpected consequences for fruit development.
sj-docx-1-otj-10.1177_15394492221142597 – Supplemental material for Challenges and Facilitators to Telehealth Occupational Therapy for Autistic Children During COVID-19
Creators: name: Angell, Amber M.
name: Carreon, Elaine D.
name: Akrofi, Joana N. S.
name: Franklin, Marshae D.
name: Taylor, Elinor E.
name: Miller, Julie
name: Crowley, Catherine
name: Maher, Shona Orfirer
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-otj-10.1177_15394492221142597 for Challenges and Facilitators to Telehealth Occupational Therapy for Autistic Children During COVID-19 by Amber M. Angell, Elaine D. Carreon, Joana N. S. Akrofi, Marshae D. Franklin, Elinor E. Taylor, Julie Miller, Catherine Crowley and Shona Orfirer Maher in OTJR: Occupation, Participation and Health
Effect of ultrafiltration profiling on outcomes among maintenance hemodialysis patients: a pilot randomized crossover trial
Creators: name: Narendra, Julia H.
name: Li, Quefeng
name: Hinderliter, Alan L.
name: Assimon, Magdalene M.
name: Brunelli, Steven M.
name: Wang, Yueting
name: Tugman, Matthew J.
name: Flythe, Jennifer E.
Publisher: name: Springer Nature
Year: 2020

description: BackgroundMore rapid fluid removal during hemodialysis is associated with adverse cardiovascular outcomes and longer dialysis recovery times. The effect of ultrafiltration (UF) profiling, independent of concomitant sodium profiling, on markers of intradialytic hemodynamics and other outcomes has been inadequately studied.MethodsFour-phase, blinded crossover trial. Participants (UF rates>10 mL/h/kg) were assigned in random order to receive hemodialysis with UF profiling (constantly declining UF rate, intervention) vs. hemodialysis with conventional UF (control). Each 3-week 9-treatment period was followed by a 1-week 3-treatment washout period. Participants crossed into each study arm twice (2 phases/arm); 18 treatments per treatment type. The primary outcomes were intradialytic hypotension, pre- to post-dialysis troponin T change, and change from baseline in left ventricular global longitudinal strain. Other outcomes included intradialytic symptoms and blood volume measured-plasma refill (post-dialysis volume status measure), among others. Each participant served as their own control.ResultsOn average, the 34 randomized patients (mean age 56 years, 24% female, mean dialysis vintage 6.3 years) had UF rates>10 mL/h/kg in 56% of treatments during the screening period. All but 2 patients completed the 15-week study (prolonged hospitalization, kidney transplant). There was no significant difference in intradialytic hypotension, troponin T change, or left ventricular strain between hemodialysis with UF profiling and conventional UF. With UF profiling, participants had significantly lower odds of light-headedness and plasma refill compared to hemodialysis with conventional UF.ConclusionsUltrafiltration (UF) profiling did not reduce the odds of treatment-related cardiac stress but did reduce the odds of light-headedness and post-dialysis hypervolemia.Trial registrationClinicaltrials.gov identifier: NCT03301740 (registered October 4, 2017)
Additional file 4 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 4.
60959: Letter describing how the photograph after an advance on the Somme (13th Royal Fusiliers) was taken
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: This letter is from the son of Horace Foakes to his family. It describes how a famous photograph of a group of soldiers (13th BN Royal Fusiliers) was taken after their advance on the Somme on the 7th July 1916.
The photograph has been contributed separately to the archive, along with Horace Foakes memoirs of how he won his military medal.
Assessment of the Required Maximum-Power-Point-Tracking Speed for Vehicle-Integrated Photovoltaics Based on Transient Irradiation Measurements and Dynamic Electrical Modeling
Creators: name: Salomon, Leon
name: Wetzel, Gustav
name: Krügener, Jan
name: Peibst, Robby
Publisher: name: Weinheim : Wiley-VCH
Year: 2023
Subjects: subject: irradiation measurements
subject: maximum power point trackings
subject: transient electrical simulations
subject: vehicle-integrated photovoltaics
subject: Dewey Decimal Classification::600 | Technik

description: Fast changing irradiation on vehicle-integrated photovoltaic (VIPV) modules may impose demanding requirements for maximum power point tracking (MPPT) to ensure high energy conversion efficiency. In this work, the results of simulations regarding the output and efficiency of an exemplary VIPV module under real-life irradiation conditions as measured with high time resolution are resulted. Herein, resistive as well as voltage source load is used as two idealized models of the MPPT. The simulations show that, in most cases, tracking with a resistive load at 1 Hz preserves above 90%rel of the convertible energy determined by the cell performances under given irradiance levels. With a voltage source load, these values do not undercut 97%rel at 0.1 Hz. Herein, it is also found that partial shading across the exemplary series connected module can reduce the converted energy in the range of 5–10%rel in relation to complete negligence of this effect.
Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial
Creators: name: Prinstein, Mitchell J.
name: Rubinow, David R.
name: Walsh, Erin C.
name: Schmalenberger, Katja M.
name: Young, Steven L.
name: Eisenlohr-Moul, Tory A.
name: Girdler, Susan S.
name: Bowers, Savannah M.
Publisher: name: Springer Nature
Year: 2022

description: Female suicide attempts peak peri-menstrually-around the onset of menses-when the ovarian steroids estradiol (E2) and progesterone (P4) fall rapidly. Given preclinical evidence that withdrawal from either E2 or P4 can provoke behaviors consistent with elevated suicide risk, we hypothesized that withdrawal from one or both of these steroids contributes to perimenstrual exacerbation of suicidal ideation (SI) and related symptoms. In a randomized, controlled, double-blind crossover experiment (NCT03720847), a transdiagnostic sample of naturally cycling, medically healthy psychiatric outpatients reporting past-month SI completed two conditions during two different 14-day experimental intervals (days 7-20 where the luteinizing hormone surge=day 0), separated by a monthlong washout cycle. In the E2 and P4 (EP) condition, participants received transdermal E2 (0.1mg/day) plus oral micronized P4 (200mg/day as 100mg twice daily) to buffer perimenstrual steroid withdrawal. A matched placebo (PBO) condition allowed natural perimenstrual steroid withdrawal. Participants reported daily SI and planning (primary outcomes) and indices of depression (low mood, hopelessness), threat sensitivity (anxiety, perceived stress), executive functioning (difficulty concentrating, impulsivity), and social cognitive bias (rejection sensitivity, perceived burdensomeness). In baseline cycles, no participant met prospective criteria for DSM-5 premenstrual dysphoric disorder, but 59% met all criteria except full follicular symptom remission, and 93% showed the highest SI in the perimenstrual phase. Of 29 randomized, 28 were analyzed (14 EP-PBO, 14 PBO-EP). Experimental administration of E2 and P4 (relative to PBO) reduced perimenstrual exacerbation of SI, suicide planning, depression, hopelessness, perceived stress, rejection sensitivity, and perceived burdensomeness, particularly in the perimenstrual (natural E2 and P4 withdrawal) days. Further, delayed withdrawal from experimental E2 and P4 (but not PBO) recapitulated SI, hopelessness, and rejection sensitivity. Acute perimenstrual withdrawal from ovarian steroids may play a causal role in perimenstrual worsening of depression and SI.
End-to-End Automated Exploit Generation for Processor Security Validation
Creators: name: Zhang, Rui
name: Huang, Peng
name: Deutschbein, Calvin
name: Sturton, Cynthia
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2021

description: Editor's notes: This article presents an end-to-end tool that, starting from a processor and a set of security-critical invariants, automatically generates exploits to help designers find security threats. -Rosario Cammarota, Intel Labs -Francesco Regazzoni, University of Amsterdam and Universit della Svizzera Italiana
Machine Translation: Past, Present And Future
Creators: name: Stein, Daniel
Publisher: name: Zenodo
Year: 2018

description: The attempt to translate meaning from one language to another by formal means

traces back to the philosophical schools of secret and universal languages as they

were originated by Ramon Llull (13th c.) or Johann Joachim Becher (17th c.). Today,

machine translation (mt) is known as the crowning discipline of natural language

processing. Due to current mt approaches, the time needed to develop new systems

with similar power to older ones has decreased enormously. In this article, the

history of mt, the difference with computer aided translation, current approaches

and future perspectives are discussed.
Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium
Creators: name: Wang, Anting
name: Jacobs, Tim M.
name: Newby, Jay
name: Schaefer, Alison
name: Parker, Christina L.
name: Nguyen, Alexander
name: Huckaby, Justin T.
name: Lai, Samuel K.
name: Wadsworth, Daniel
Publisher: name: Wiley
Year: 2019

description: Mucus represents a major barrier to sustained and targeted drug delivery to mucosal epithelium. Ideal drug carriers should not only rapidly diffuse across mucus, but also bind the epithelium. Unfortunately, ligand-conjugated particles often exhibit poor penetration across mucus. In this work, we explored a two-step "pretargeting" approach through engineering a bispecific antibody that binds both cell-surface ICAM-1 and polyethylene glycol (PEG) on the surface of nanoparticles, thereby effectively decoupling cell targeting from particle design and formulation. When tested in a mucus-coated Caco-2 culture model that mimics the physiological process of mucus clearance, pretargeting increased the amount of PEGylated particles binding to cells by around 2-fold or more compared to either non-targeted or actively targeted PEGylated particles. Pretargeting also markedly enhanced particle retention in mouse intestinal tissues. Our work underscores pretargeting as a promising strategy to improve the delivery of therapeutics to mucosal surfaces.
Genetic Characterization Of 'Candidatus Liberibacter Solanacearum' Strains Infecting Carrot Psyllids In Southwestern France
Creators: name: Bergey Bernard
name: Eveillard Sandrine
name: Foissac Xavier
Publisher: name: Zenodo
Year: 2017

description: GENETIC CHARACTERIZATION OF ‘CANDIDATUS LIBERIBACTER SOLANACEARUM’ STRAINS INFECTING CARROT PSYLLIDS IN SOUTHWESTERN FRANCE

B. Bergey, S. Eveillard, X. Foissac

UMR1332 Fruit Biology and Pathology, INRA and University of Bordeaux, CS20032, F-33882 Villenave d’Ornon, France. E-mail: sandrine.eveillard@inra.fr.

The phloem-limited bacterium, Candidatus Liberibacter solanacearum (CaLsol), is responsible of several diseases on Solanaceae (USA, New-Zealand) and Apiaceae such as carrots in several European countries (Spain, France Scandinavia, Germany). This bacterium is vectored by psyllids, Bactericera cokerelli to potatoes, or B. trigonica and Trioza apicalis to carrots. In France, since the 1970s, proliferation of carrot was shown to be associated with a psyllid-transmitted, phloem limited bacterium. In order to reassess disease impact and better characterize the bacterium involved, five organic or non-organic carrot fields were surveyed in 2016 for CaLsol and psyllids in three production areas of Southwestern France. Psyllids were present at spring and summer only in an organic experimental field, but could be captured from September in all fields. The highest level of psyllid populations was reached in October when up to 350 specimens were collected upon 100 sweeps. Psyllids collected on carrots were most probably Bactericera trigonica. CaLsol could be detected by Taqman real-time PCR (Teresani et al., 2014) in psyllids as well as in carrots exhibiting stem proliferation and stunting. CaLsol detection ranged from 0 to 18% in individual psyllids and from 0 to 9% in carrots. In Europe, the two ribosomal CaLsol haplotypes D and E have been characterized based on the 16S rDNA and the 16S-23S spacer sequences. In the present survey, haplotype E was identified in both carrot and psyllids, as well as haplotype D2, a new haplotype differing from the haplotype D by two SNPs. Genotyping using the five most variable gene markers described by Glynn and collaborators (2012) showed that the two haplotypes differed for all five markers dnaG, metG, recA, mutS and adk, with mutS being the most discriminant with 8 SNPs between haplotype E and D2.

This project has received funding from the European Union"s Horizon 2020 research and innovation programme under grant agreement No 635646: POnTE (Pest Organisms Threatening Europe)

The present work reflects only the author's view and the EU Funding Agency is not responsible for any use that may be made of the information it contains
description: presented at HPIS Hemipteran-Plant Interactions Symposium held in Madrid, Spain, in June 4-8, 2017.
60962: German postcard and photograph souvenired by George Powell
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: George Powell was a very small man and was enlisted into The Welsh Bantams. Being of a very young age when the war began he joined by stating he was older than his correct age. By the end of the Great War George had spent a year in hospital suffering horrific injuries. Editor's Comment: Presumably picked up from the battlefield as souvenirs. The postcard depicts German soldiers in a buring village and bears a Feldpost stamp to the reverse; the photograph is of a German signalling unit, with signalling lamp (Blinkgerät) on tripod. Private George Powell would have enlisted as a Bantam in the 17th (Service) Bn. (1st Glamorgans), The Welsh Regiment.
Additional file 5 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 5.
Search For Solar Atmospheric Neutrinos With The Icecube Neutrino Observatory
Creators: name: ROTT, Carsten
Publisher: name: Zenodo
Year: 2018

description: Cosmic ray interactions with the solar atmosphere are expected to generate energetic neutrinos that might be observable with neutrino telescopes, such as IceCube. These so called solar atmospheric neutrinos are expected to have a harder energy spectrum compared to those generated in the Earth atmosphere. The difference originates from the lower atmospheric density of the Sun, which allows secondary particles to decay rather than to reinteract. We present the first search for solar atmospheric neutrinos, using eight years of data collected with IceCube. To distinguish signal from backgrounds we perform a likelihood analysis using directional and energy spectral information. The analysis method and optimization will be introduced and sensitivities presented.
Additional file 6 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 6.
The 'selected' and the 'ejected': The making of student subjectivity within four Australian selective schools
Creators: name: MELISSA ROSE THAM
Publisher: name: Monash University
Year: 2020
Subjects: Education

description: This research explores the processes of selection and selective schools through the perspectives of students who have been ‘selected’, as well as those who have been ‘ejected’ or have left selective schools prior to graduation. Underpinned by Foucault’s concepts of power and discourse, the operations of power, student subjectivities and the effects of selective schooling as it relates to elite and state schooling are analysed. The research highlights four discourses that shape selected students: opportunity, 'superiors', 'more than marks' and 'student wellbeing.' It argues that through an ambivalent and paradoxical experience of selective schooling, ‘ambivalent’ subjectivities are made; characterised by a sense of unease and uncertainty about oneself and one's future. Implications for research on selective schooling and student subjectivity are discussed.
Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems
Creators: name: O'Banion, Colin P.
name: Parag-Sharma, Kshitij
name: Henry, Erin C.
name: Musicant, Adele M.
name: Lawrence, David S.
name: Cleveland, John L.
name: Amelio, Antonio L.
Publisher: name: American Chemical Society (ACS)
Year: 2019

description: Light-inducible optogenetic systems offer precise spatiotemporal control over a myriad of biologic processes. Unfortunately, current systems are inherently limited by their dependence on external light sources for their activation. Further, the utility of laser/LED-based illumination strategies are often constrained by the need for invasive surgical procedures to deliver such devices and local heat production, photobleaching and phototoxicity that compromises cell and tissue viability. To overcome these limitations, we developed a novel BRET-activated optogenetics (BEACON) system that employs biologic light to control optogenetic tools. BEACON is driven by self-illuminating bioluminescent-fluorescent proteins that generate "spectrally tuned" biologic light via bioluminescence resonance energy transfer (BRET). Notably, BEACON robustly activates a variety of commonly used optogenetic systems in a spatially restricted fashion, and at physiologically relevant time scales, to levels that are achieved by conventional laser/LED light sources.
Anais do CONEPE - 2a Edição
Creators: name: Universidade Federal de Goiás
Publisher: name: Zenodo
Year: 2017
Subjects: CONEPE
UFG-Regional Jataí

description: Os Anais da 2ª edição do CONEPE - Congresso de Ensino, Pesquisa e Extensão de 2017, cujo tema foi “A Matemática está em tudo”, contaram com a apresentação de 307 trabalhos científicos envolvendo ensino, pesquisa e extensão, produzidos na instituição nos cursos de graduação e pós-graduação, com a participação de alunos, docentes e técnico-administrativos. Os trabalhos foram apresentados em 10 diferentes modalidades:

- Seminário de Pós-Graduação – Doutorado (COPG);

- Seminário de Pós-Graduação – Mestrado (COPG);

- Programa de Iniciação à Docência – PIBID (COGRAD);

- Programa de Bolsistas e Voluntários de Licenciatura – PROLICEN (COGRAD);

- Programa de Monitoria Acadêmica (COGRAD);

- Programa de Educação Tutorial – PET (COGRAD);

- Programa de Bolsa de Extensão e Cultura – PROBEC (COEC);

- Mostra de Extensão e Cultura (COEC);

- Mostra de Pesquisa, Inovação e Desenvolvimento Tecnológico (COPI);

- Mostra Universitária (COPG).
66033: Ivor Gurney in Uniform
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Photograph of Ivor Gurney in the uniform of the 2nd/5th Gloucester Regiment. The photograph mount is annotated in ink by Herbert Howells, 'Ivor Gurney ("Bartholomew")' - the latter being Gurney's nickname amongst his friends at the Royal College of Music.
Supplemental Material - Indocyanin Green Fluorescence Evaluation of Colonic Perfusion During Elective Open Abdominal Aortic Aneurysm Repair
Creators: name: Tam, Adam
name: Abdel-Rahim, Ahmed
name: Dix, Francis
name: Barwell, Jamie
name: Mittapalli, Devender
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Cardiology
classificationCode: 110323
subject: Surgery

description: Supplemental Material for Indocyanin Green Fluorescence Evaluation of Colonic Perfusion During Elective Open Abdominal Aortic Aneurysm Repair by Adam Tam, Ahmed Abdel-Rahim, Francis Dix, Jamie Barwell, and Devender Mittapalli in Vascular and Endovascular Surgery.
La gestion des ressources humaines: un levier pour la performance de l’entreprise
Creators: name: Soltani, Mohamed Zouhaier
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: GRH, approche universaliste, approche de contingence, approche de configuration, théorie des ressources…

description: La présente recherche a pour objectif d’analyser l’impact des bonnes pratiques de la Gestion des Ressources Humaines(GRH) sur la performance financière de l’entreprise, comme le stipule l’approche universaliste : Toute bonne pratique de GRH procure à l’entreprise qui y recourt un avantage compétitif. Les réponses à cette affirmation sont nombreuses et diversifiées en raison des contextes et environnements dans lesquels se situent les entreprises. Le test de cette hypothèse, à travers une étude monographique, au sein d’une Cimenterie localisée au Nord Ouest Tunisien, pour une période de 5 ans, montre des résultats substantiels quant à l’association des pratiques de la GRH à la performance financière. Les variables explicatives telles que la formation, la rémunération et certaines variables catégorielles du climat social indiquent une corrélation positive. D’autres variables catégorielles liées au climat social et aux conditions de travail sont corrélées négativement à la performance financière, ce qui semble paradoxale.
description: Revue Economie, Gestion et Société, No 4 (2015)
Measurement Of Neutrino Interactions On Water And Hydrocarbon With A 3D-Grid Detector In The Wagasci Experiment
Creators: name: KIN, Ken'ichi
Publisher: name: Zenodo
Year: 2018

description: The WAGASCI experiment is being carried out at J-PARC to precisely measure the neutrino cross-section ratio between water and hydrocarbon target. We constructed a new detector which consists of a water target module, hydrocarbon target module, and muon-range detector. Scintillators of the water module have a characteristic 3D-grid structure, which achieves a large solid angle acceptance. We started the anti-neutrino beam measurement in October 2017. We request statistics of 9.0×10^20 POT (Proton On Target) until May 2018, and about 1000 signal events are expected to be observed by the Monte-Carlo simulation. We collected about 3.7×10^20 POT so far. Neutrino events were successfully observed and reconstructed in the detector. We report on the detector status and the first results from the anti-neutrino beam measurement.
title: Bioinformatics approaches to study molecular sex differences in complex diseases
Creators: name: Rebecca Ting Jiin Loo
name: Mohamed Soudy
name: Francesco Nasta
name: Mirco Macchi
name: Enrico Glaab
Publisher: name: LCSB
Year: 2024

description: Many complex diseases exhibit pronounced differences between the sexes, which can affect both the initial risk of developing the disease, as well as clinical disease symptoms, molecular manifestations, disease progression and the risk of developing comorbidities. Despite this, computational studies on molecular data for complex diseases often treat sex merely as a confounding variable, aiming to filter out sex-specific effects rather than attempting to interpret them. A more systematic, in-depth exploration of sex-specific disease mechanisms could significantly improve our understanding of pathological and protective processes with sex-dependent profiles.
This survey discusses dedicated bioinformatics approaches for studying molecular sex differences in complex diseases. It highlights that, beyond classical statistical methods to investigate sex differences, approaches are needed to interpret sex-dependent alterations in diseases mechanistically, integrating prior knowledge of relevant hormone signaling interactions, gene regulatory networks, and sex linkage of genes. The review explores and compares the benefits, pitfalls, and limitations of different conventional statistical and systems level mechanistic analyses to this end, including tailored pathway and network analysis techniques.
Overall, this review highlights the potential of specialized bioinformatics techniques to systematically investigate molecular sex differences in complex diseases, to inform biomarker signature modeling, and guide more personalized treatment approaches.
Enigmatic MELK: The controversy surrounding its complex role in cancer
Creators: name: McDonald, Ian M
name: Graves, Lee M
Publisher: name: Elsevier
Year: 2020

description: The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been considered an attractive therapeutic target for managing cancer since 2005. Studies using expression analysis have indicated that MELK expression is higher in numerous cancer cells and tissues than in their normal, nonneoplastic counterparts. Further, RNAi-mediated MELK depletion impairs proliferation of multiple cancers, including triple-negative breast cancer (TNBC), and these growth defects can be rescued with exogenous WT MELK, but not kinase-dead MELK complementation. Pharmacological MELK inhibition with OTS167 (alternatively called OTSSP167) and NVS-MELK8a, among other small molecules, also impairs cancer cell growth. These collective results led to MELK being classified as essential for cancer proliferation. More recently, in 2017, the proliferation of TNBC and other cancer cell lines was reported to be unaffected by genetic CRISPR/Cas9-mediated MELK deletion, calling into question the essentiality of this kinase in cancer. To date, the requirement of MELK in cancer remains controversial, and mechanisms underlying the disparate growth effects observed with RNAi, pharmacological inhibition, and CRISPR remain unclear. Our objective with this review is to highlight the evidence on both sides of this controversy, to provide commentary on the purported requirement of MELK in cancer, and to emphasize the need for continued elucidation of the functions of MELK.
sj-docx-1-jbr-10.1177_07487304231180953 – Supplemental material for Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator
Creators: name: Stowe, Shelby R.
name: LeBourgeois, Monique K.
name: Diniz Behn, Cecilia
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 110306
subject: Endocrinology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Neuroscience

description: Supplemental material, sj-docx-1-jbr-10.1177_07487304231180953 for Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator by Shelby R. Stowe, Monique K. LeBourgeois and Cecilia Diniz Behn in Journal of Biological Rhythms
LE TAUX DE CHANGE REEL D’EQUILIBRE : UNE ETUDE APPLIQUEE POUR LE CAS DU MAROC
Creators: name: AMMARI, FADWA
name: ASSELLAM, LAHOUCINE
name: El Marhom, Adil
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Terme de l’échange (%PIB), taux d’ouverture (% PIB), productivité, dette extérieure, taux de change nominal, mésalignements.

description: Cet article présente une application du taux de change réel d’équilibre pour le cas du Maroc. Afin d’estimer le modèle, nous allons utiliser le modèle d’Edwards (1998) et de Elbadawi (1994). En procédant à l’analyse des données, nous utilisons la technique de la cointégration pour le modèle de long terme du taux de change réel. L’estimation porte sur 28 observations pour la période allant de 1980 à 2007. Les fondamentaux à utiliser sont : L’indice de productivité, l’investissement direct étranger en pourcentage du PIB, la dette extérieur, le taux de change nominal, l’investissement en pourcentage du PIB, la dépense public en pourcentage du PIB, les termes de l’échange extérieur, et le taux d’ouverture de l’économie. Le travail se base sur la sélection à partir de ces variables des plus signifiants afin d’expliquer l’évolution du taux de change. Finalement, nous procédons au calcul de la distorsion entre le taux de change réel observé et le taux de change réel de long terme et les mésalignements s’y afférant.
description: Revue Economie, Gestion et Société, No 3 (2015)
Comparative Evaluation of PCT Measurement Using Three Different Chemiluminescence Methods
Creators: name: MALLIARAKI, NIKI
name: Katrinaki, Marianna
name: Anagnostopoulou, Vasileia
name: Zavitsanou, Konstantina
name: Psathaki, Maria
name: Fragiadouli, Eleftheria
name: Tsatsanis, Christos
Publisher: name: Zenodo
Year: 2024

description: Procalcitonin (PCT) is now being recognized as a useful tool for monitoring infection and inflammation. Several vendors provide PCT measurement approaches using different detection reagents. In this analysis we compared Snibe MAGLUMI PCT, Beckman Dxi PCT and Roche Elecsys BRAHMS PCT, the latter being the method used to define the clinical decision cutoff points. We compared the analytical performance and the correlation between the different kits. Procalcitonin was evaluated in 122 samples by using MAGLUMI PCT assay (SNIBE), Elecsys BRAHMS PCT assay (Roche), and Dxi PCT assay (Beckman). We collected the samples from patients in the Intensive Care Unit (ICU) of the University Hospital of Heraklion. The linearity as well as the method of measurement were compared. The effect of Freezing and thawing was also evaluated. The data were analyzed using Passing-Bablok regression on MedCalc software. Additionally, we also evaluated the positive-negative agreement between samples. The results showed that one cycle of freezing and thawing did not have any effect in the PCT values obtained. There was a very good correlation between all three assays, with the strongest correlation being between Elecsys BRAHMS PCT and MAGLUMI PCT assays. Correlations between the different clinical cutoff points were provided showing that the closest correlation was between MAGLUMI PCT and Elecsys BRAHMS PCT.
Additional file 1 of Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study
Creators: name: Zhang, Bin
name: Xi, Sijie
name: Liu, Renchen
name: Han, Xiaoya
name: Long, Wei
name: Yuan, Xiaosong
name: Yu, Bin
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 1
Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson's Disease with Mild Cognitive Impairment
Creators: name: Wang, Zhijiang
name: Yang, Tao
name: Jia, Xiuqin
name: Li, Ying
name: Wu, Guorong
name: Jiang, Tao
name: Gao, Shuai
name: Liang, Peipeng
Publisher: name: Aging and Disease
Year: 2019

description: Patients with Parkinson's disease (PD) generally have a higher proportion of suffering from mild cognitive impairment (MCI) than normal aged adults. This study aimed to identify the specific neuroanatomical alterations in early, drug-naive PD with MCI (PD-MCI) by comparing to those PD with normal cognition (PD-NC) and healthy controls (HCs), which could help to elucidate the underlying neuropathology and facilitate the development of early therapeutic strategies for treating this disease. Structural MRI data of 237 early, drug-naive non-demented PD patients (classified as 61 PD-MCI and 176 PD-NC) and 69 HCs were included from Parkinson's Progression Markers Initiative (PPMI) database after data quality control. Within these data, a subset of 61 HCs and a subset of 61 PD-NC who were matched to the 61 PD-MCI group for age, gender, and education-level were selected to further eliminate the sample size effect. The gray matter (GM) volume changes between groups were analyzed using voxel-based morphometry (VBM). Furthermore, correlations between GM volume alterations and neuropsychological performances and non-cognitive assessments (including olfactory performance) were further examined. Compared to HC, patients with PD-NC and PD-MCI commonly exhibited atrophies in the bilateral amygdala (AM) and the left primary motor cortex (M1). Patients with PD-MCI exclusively exhibited atrophy in the right entorhinal cortex (ENT) compared to PD-NC. Significantly negative correlations were found between GM loss in the bilateral AM and olfactory performance in all PD patients, and between ENT loss and memory performance in PD-MCI. The findings suggest that the right ENT atrophy may subserve as a biomarker in early, drug-naive PD-MCI, which shed light on the neural underpinnings of the disease and provide new evidence on differentiating the neuroanatomical states between PD-MCI and PD-NC.
A Data Conceptual Framework for Injury Prevention
Creators: name: ANGELO DOMINIC D'ELIA
Publisher: name: Monash University
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Quality data is of fundamental importance to taking a scientific and evidence-based approach to injury prevention that improves our understanding of the cause and consequence of injury and enables the effective development, implementation and evaluation of injury prevention interventions. However to date, no comprehensive and cohesive data framework to enable the systematic collection of data to support the injury prevention evidence-base has been defined. This thesis defines a data conceptual framework for injury prevention to fully build the injury prevention evidence-base, and demonstrates its operationalisation and value to injury prevention research using real world contexts.