cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development
Creators: name: Gobinath, Aarthi R.
name: Workman, Joanna L.
name: Chow, Carmen
name: Lieblich, Stephanie E.
name: Galea, Liisa A. M.
Publisher: name: BioMed Central
Year: 2017

description: Background: Postpartum depression affects approximately 15% of mothers and represents a form of early life adversity for developing offspring. Postpartum depression can be treated with prescription antidepressants like fluoxetine (FLX). However, FLX can remain active in breast milk, raising concerns about the consequences of neonatal FLX exposure. The hippocampus is highly sensitive to developmental stress, and males and females respond differently to stress at many endpoints, including hippocampal plasticity. However, it is unclear how developmental exposure to FLX alters the trajectory of hippocampal development. The goal of this study was to examine the long-term effects of maternal postpartum corticosterone (CORT, a model of postpartum depression) and concurrent FLX on hippocampal neurogenesis in male and female offspring. Methods: Female Sprague-Dawley rat dams were treated daily with either CORT or oil and FLX or saline from postpartum days 2–23. Offspring were perfused on postnatal day 31 (pre-adolescent), postnatal day 42 (adolescent), and postnatal day 69 (adult). Tissue was processed for doublecortin (DCX), an endogenous marker of immature neurons, in the dorsal and ventral hippocampus. Results: Maternal postpartum CORT reduced density of DCX-expressing cells in the dorsal hippocampus of pre-adolescent males and increased it in adolescent males, suggesting that postpartum CORT exposure disrupted the typical progression of the density of DCX-expressing cells. Further, among offspring of oil-treated dams, pre-adolescent males had greater density of DCX-expressing cells than pre-adolescent females, and maternal postpartum CORT prevented this sex difference. In pre-adolescent females, maternal postpartum FLX decreased the density of DCX-expressing cells in the dorsal hippocampus compared to saline. As expected, maternal CORT reduced the density of DCX-expressing cells in adult female, but not male, offspring. The combination of maternal postpartum CORT/FLX diminished density of DCX-expressing cells in dorsal hippocampus regardless of sex or age. Conclusions: These findings reveal how modeling treatment of postpartum depression with FLX alters hippocampal neurogenesis in developing offspring differently depending on sex, predominantly in the dorsal dentate gyrus and earlier in life.
Interaction of Microplastics with Trace Metals and Bacteria, and Potential Impacts on Fish
Creators: name: Jang, Faddrine Holt Ajon
Publisher: name: Swinburne
Year: 2024

description: Microplastics' abundance in the aquatic environment have been documented numerously, nevertheless their associated chemical and biological hazards are somewhat understudied. This research therefore aimed to assess the interactions of microplastics with trace metals and bacteria in the aquatic ecosystem; and risks they pose to fish upon ingestion. Results showed successful attachment of both components to microplastic surfaces; and were efficiently transferred to fish. This research highlighted potential risks microplastics pose to aquatic environment; by acting as sinks, dispersal means, as well as shuttles for contaminants transfer to ingesting organisms which leads to bioaccumulation and potential toxicity.
Inferring physiological mechanisms in the human cortex by fitting a neural population model to EEG data
Creators: name: Hartoyo, Agus
Publisher: name: Swinburne
Year: 2024

description: This thesis explores how physiological mechanisms in the human cortex can be inferred by fitting a neural population model to electroencephalogram data. We focus on two well-known but poorly understood features of the electroencephalogram, alpha oscillations and alpha-blocking. By fitting the model to electroencephalogram data from 82 individuals we distill the physiological drivers for each phenomenon that are common across all subjects, despite the considerable between-individual variation in electroencephalogram characteristics. We show how the specific mechanisms underlying the two phenomena can be identified by a posteriori fits to electroencephalogram data rather than by a priori hypothesis.
title: ÐÐ°Ð¿Ð¸ÑÑ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸ Ð² ÑÑÐµÐºÐ»Ð°Ñ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ð¾Ð³Ð¾ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Recording optical information in glasses using electronic irradiation
Creators: name: ÐÐ¾ÑÐ¾Ð»ÐµÐ², ÐÐ²Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ
ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ð¾-Ð»ÑÑÐµÐ²Ð°Ñ ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ°
ÑÐ¾ÑÐ¾ÑÐµÑÐ¼Ð¾ÑÐµÑÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ðµ ÑÑÐµÐºÐ»Ð¾
ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ð¾Ðµ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ðµ
Ð»ÑÐ¼Ð¸Ð½ÐµÑÑÐµÐ½ÑÐ¸Ñ
optical information
electron beam installation
photothermorefractive glass
electronic irradiation
luminescence

description: ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â Ð¤Ð¢Ð -ÑÑÐµÐºÐ»Ð¾. Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ â Ð·Ð°Ð¿Ð¸ÑÐ°ÑÑ Ð¿Ð¾ÑÑÐµÐ´ÑÑÐ²Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ð¾Ð³Ð¾ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ Ð² ÑÑÐµÐºÐ»Ð¾ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ Ð¸ ÑÑÐ¸ÑÐ°ÑÑ ÐµÐµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð»Ð°Ð·ÐµÑÐ°. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ð¾Ðµ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ðµ ÑÐ¾ÑÐ¾ÑÐµÑÐ¼Ð¾ÑÐµÑÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ ÑÑÐµÐºÐ»Ð°, Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÑÐµÐ±ÑÐ¾Ð¼, Ñ ÑÐµÐ»ÑÑ Ð·Ð°Ð¿Ð¸ÑÐ°ÑÑ Ð² Ð½ÐµÐ³Ð¾ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ. ÐÐ±Ð»ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ð¿ÑÐ¸ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ, Ð´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ Ð±Ð¾Ð»ÑÑÐ¸Ñ ÑÐ½ÐµÑÐ³Ð¸ÑÑ Ð¸ Ð´Ð¾Ð·Ð°Ñ. ÐÑÐ»Ð¾ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð¾Ð² Ð½Ð° Ð¤Ð¢Ð -ÑÑÐµÐºÐ»Ð¾. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° Ð¿Ð¾Ð»ÑÑÐ¸Ð»Ð¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð½Ð¾Ðµ ÑÑÐµÐºÐ»Ð¾, Ð½Ð°Ð´ÐµÐ»ÐµÐ½Ð½Ð¾Ðµ Ð·Ð°Ð´Ð°Ð½Ð½Ð¾Ðµ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸ÐµÐ¹. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð»Ð°Ð·ÐµÑÐ° ÑÐµÐ·ÑÐ»ÑÑÐ°Ñ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ Ð±ÑÐ» Ð²Ð¾ÑÐ¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ Ð½Ð°Ð³Ð»ÑÐ´Ð½Ð¾. ÐÑÐ»Ð° Ð´Ð¾ÐºÐ°Ð·Ð°Ð½Ð° Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ ÑÑÐµÐºÐ»Ð° Ñ ÑÐµÐ»ÑÑ Ð·Ð°Ð¿Ð¸ÑÐ¸ Ð¸ ÑÑÐ°Ð½ÐµÐ½Ð¸Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸.
description: The object of the study - FTR glass. The purpose of the work - to record optical information into glass by means of electronic irradiation and read it using a laser. In the course of the work, electronic irradiation of photothermorefractive glass doped with silver was carried out in order to record optical information into it. The irradiation was carried out at various, rather high energies and doses. The effect of the action of electrons on the FTR glass was considered. As a result of the experiment, irradiated glass was obtained, endowed with a given optical information. With the help of a laser, the result of irradiation was reproduced visually. It has been proven promising to use glasses for the purpose of recording and storing information.
A Drosophila Model of Lowe Syndrome
Creators: name: Biber, Sarah
Publisher: name: Brandeis University
Year: 2014
Subjects: Drosophila
Lowe Syndrome
phosphoinositide metabolism

description: Lowe syndrome is an X-linked disorder caused by mutations in OCRL (Oculocerebrorenal Syndrome of Lowe), a phosphatidylinositol-5-phosphatase with previously identified roles in endocytic trafficking, phosphoinositide metabolism, cytokinesis, and cilium formation and function. However it is not understood how defects in the OCRL enzyme result in the debilitating neurological, kidney and eye symptoms that are prevalent in Lowe syndrome. We have taken advantage of the high conservation of OCRL between humans and insects to model Lowe syndrome in Drosophila melanogaster. Here we have generated a Drosophila OCRL (dOCRL) null mutant with deficiencies at both the cellular and tissue levels. Loss of dOCRL causes lethality in larval stages. Third instar larvae lacking dOCRL present with large melanotic masses, and hemocyte proliferation, differentiation and morphology defects. We thus decided to use the innate immune system as a novel arena for investigating the in vivo cellular functions of dOCRL and several of its conserved binding partners. Consistent with mammalian studies, our data indicates that dOCRL localizes to early endosomes and co-localizes with the PH domain-containing protein dSes/CG12393. Loss of dOCRL in hemocytes promotes multinucleation, which is consistent with knockdown experiments in mammalian and S2 cell cultures. dOCRL mutant hemocytes also present with massively up-regulated F-actin and significant increases in plasmatocyte spikiness. All of the observed defects in dOCRL hemocytes are rescued cell-autonomously. Furthermore, rescue is dependent on the phosphoinositide-5-phosphatase activity of dOCRL. Our findings suggest that hematopoietic phenotypes observed in the dOCRL mutant may result from changes in Toll signaling. This work has established and validated a new animal model of Lowe Syndrome and uncovered a potential new role for dOCRL in fly hematopoiesis and immunity.
How basic-level objects facilitate question-asking in a categorization task
Creators: name: Ruggeri, Azzurra
name: Feufel, Markus A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie

description: The ability to categorize information is essential to everyday tasks such as identifying the cause of an event given a set of likely explanations or pinpointing the correct from a set of possible diagnoses by sequentially probing questions. In three studies, we investigated how the level of inclusiveness at which objects are presented (basic-level vs. subordinate- level) influences children's (7- and 10-year-olds) and adults' performance in a sequential binary categorization task. Study 1 found a robust facilitating effect of basic-level objects on the ability to ask effective questions in a computerized version of the Twenty Questions game. Study 2 suggested that this facilitating effect might be due to the kinds of object-differentiating features participants generate when provided with basic-level as compared to subordinate-level objects. Study 3 ruled out the alternative hypothesis that basic-level objects facilitate the selection of the most efficient among a given set of features.
Creative energies and contemporary modes: The changing hymnody of the United Church of Canada.
Creators: name: Williamson, Patricia Bernard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Religion, General.

description: While traditional hymns are still in use in the United Church of Canada, many of them reflect the musical styles and theological concepts of past generations. Hymns in a more popular, contemporary musical idiom, expressing current beliefs and societal values are now gaining favour. Based on the assumption that music, and in particular the singing of hymns by a church community, can aid in the definition of a collective identity, and at the same time can provide a vehicle for the expression of individual needs, aspirations, and emotions, this thesis examines the various hymnals that have been used by the United Church of Canada as an articulation of theological, social, and individual concerns of particular times, places and communities. Through an ethnography of a particular church congregation, this study examines how their choice of hymns and performance practices are fundamental to the production and expression of the distinct church culture of this community in the 1990s.
#skulldata (memory_protest)
Creators: name: Allas, Daniel
Publisher: name: Brandeis University
Year: 2017
Subjects: body
skull
data
memory
protest
Music

description: This piece endeavors to comment on the artistic trope of bodily\r \r deconstruction. In my artistic practice, I've been compelled by art that in some way\r \r includes the body, and more specifically I'm drawn to bodily references that involve\r \r a deconstruction of the vessel. I think the goal of this deconstruction is to\r \r touch/uncover something beyond the body, and this I find artistically satisfying. I\r \r also believe we struggle to accept what each of us finds during these thorough\r \r examinations; we are puzzled while discovering these invisible organs, our\r \r intangible bones. Of course, feel free to make your own connections about what\r \r these sounds suggest, whether it has to do with bodies or not.
Integrating Predictive Analytics into Diabetic Wound Care: A Path Toward Personalized Medicine. A Narrative Review
Creators: name: Lufulwabo, Aime
Publisher: name: Zenodo
Year: 2025

description: ABSTRACT

  Diabetic foot ulcers (DFUs) are a severe and costly complication of diabetes, often leading to infections, amputations, and diminished quality of life. Traditional wound care remains reactive, relying on subjective assessments and lacking predictive capabilities. This narrative review explores the integration of predictive analytics—powered by machine learning (ML) and artificial intelligence (AI)—into diabetic wound care as a pathway toward personalized medicine.

  We synthesized literature from 2014 to 2024, focusing on ML applications, predictive models, and their integration with electronic health records (EHRs), wearables, and imaging technologies. Key findings reveal that models such as logistic regression (interpretable for binary outcomes), random forests (robust for structured data), convolutional neural networks (superior for image analysis), and long short-term memory networks (effective for temporal data) enable risk stratification, healing trajectory prediction, and personalized interventions. Integration with wearables and EHRs facilitates real-time monitoring and early detection of complications, while smartphone-based AI tools enhance remote care. However, challenges persist, including data interoperability, clinician trust in “black-box” models, ethical concerns around bias, and infrastructural barriers in low-resource settings.

  The review underscores the potential of predictive analytics to transition diabetic wound management from reactive to proactive, precision-based care, reducing hospitalizations and amputations. Future directions emphasize federated learning for privacy-preserving collaboration, genomic integration for tailored therapies, and addressing gaps in multimodal datasets and external validation.

  Successful implementation requires interdisciplinary collaboration, standardized data practices, and ethical frameworks to ensure equitable, transparent, and clinically validated AI solutions.

  This synthesis highlights the transformative promise of predictive analytics in reshaping diabetic wound care while outlining critical steps for its ethical and effective adoption.
Concentration of heavy water.
Creators: name: Nguyen, Anh-Quang.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: Chemistry, Radiation.

description: A micro heavy water concentration unit using the G.S. process was constructed to study possible process improvements. The deuterium isotope exchange was performed successfully in this unit. It was found that the use of monoethanolamine (MEA) in conjunction with the G.S. process had little or no effect on the recovery fraction of heavy water from the feed. However, the experiments indicated that the gas rate could be increased to attain a higher production rate, or equivalently, for the same production rate the size of the towers could be slightly reduced. The improvement was found only marginally attractive particularly because one more stage could be needed to recover the MEA which was introduced in the feed water.
Portable autonomous window cleaning robot
Creators: name: Mir-Nasiri, Nazim
name: Hudyjaya Siswoyo, J.
name: Ali, Md. Hazrat
Publisher: name: Swinburne
Year: 2024

description: The idea of having a compact and autonomous office or house window cleaning robot is quite simple and very attractive. This small window climbing robot with pneumatic suction cups should be able to move autonomously along an outside surface of high-rise building office window with a relatively large area and meantime clean and wash it. Being manually attached to the outside surface of the room window the robot will execute and accomplish the task of window cleaning automatically in a predefined pattern. The sensory system will help to navigate the robot. It is noted that window cleaning robots are commercially available but pricey (in the range of USD 5000 or more). The designed robot is lightweight, small size and cheap because it is driven only by one rotary actuator and system of properly arranged conventional belts and pulleys. It uses the suction cups to stick to the window pane and set of optical sensors to detect the window frame. The microcontroller is programmed to move the robot in a specific pattern depending on the sensory data. There are no similar reasonably priced rival products available in the market yet.
The effect of thalidomide and its derivatives on thyroxine-induced metamorphosis of tadpole and the activity of lactate dehydrogenase isozymes during thyroxine-induced tadpole metamorphosis.
Creators: name: Kim, Hae Chang.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1966
Subjects: subject: Chemistry, Biochemistry.

description: Abstract not available.
Submerged vane performance in strongly curved narrow channel bends.
Creators: name: Voisin, Adam Francis.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Engineering, Civil.

description: Submerged vanes are thin flow-training structures that protrude above the channel bed to a height of approximately 0.2 to 0.5 times the flow depth. They have lengths of 1 to 4 times their height, and are typically angled between 5 and 30 degrees to the free-stream flow direction (counterclockwise, when viewed in plan, in a bend turning to the right). The vanes induce a secondary current which may be harnessed to counteract the centrifugally-induced helicoidal flow in channel bends. A reduction in the strength of the helicoidal current will in turn lead to a corresponding reduction in outer bank erosion. Physical model testing was performed to determine the effects of several parameters which affect submerged vane performance, namely: submerged vane height H, length L, angle to main flow direction alpha, vane streamwise spacing deltas, vane transverse spacing from outer bank deltan, and bend angle ϕ. Two bend angles were examined in this study. The majority of testing was performed in a 90° bend, and a limited number of tests were performed in a 135° bend with the same radius. (Abstract shortened by UMI.)
Nurse-led navigation to provide early palliative care in rural areas: a pilot study
Creators: name: Pesut, Barbara
name: Hooper, Brenda
name: Jacobsen, Marnie
name: Nielsen, Barbara
name: Falk, Miranda
name: O ‘Connor, Brian P
Publisher: name: BioMed Central
Year: 2017

description: Background: Few services are available to support rural older adults living at home with advancing chronic illness. The objective of this project was to pilot a nurse-led navigation service to provide early palliative support for rural older adults and their families living at home with advancing chronic illness. Methods: Twenty-five older adults and 11 family members living with advancing chronic illness received bi-weekly home visits by a nurse navigator over a 2-year period. Navigation services included symptom management, education, advance care planning, advocacy, mobilization of resources, and psychosocial support. The nurse navigator collected longitudinal data on older adult and family needs, and older adult quality of life and healthcare utilization. Results: Satisfaction with the service was high. There was no attrition over the 2-year period except through death, and few cancelled visits, indicating a high degree of acceptability of the intervention. The navigator addressed complex, multi-faceted needs through connecting health, social, and informal community resources. Participants who indicated a preferred place of death were able to die in that preferred place (n = 7). Emergency room use by participants was minimal and largely unpreventable by the nurse navigator. Longitudinal health-related quality of life scores for many participants were poor, lending further support to the need for more focused attention to this upstream palliative population. Conclusions: Using a nurse navigator to facilitate early palliative care for rural older adults living with advanced chronic illness is a promising innovation for meeting the needs of this population. Further research is required to evaluate outcomes on a larger scale.
Lesbian couples and their health: A phenomenological feminist study.
Creators: name: Polansky, Karen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Women's Studies.

description: Lesbians face oppression in their daily lives and in the health care system due to both their gender and sexual orientation. Nurses, as front line workers, have a vital role to ensure appropriate, high quality care as well as health promotion. This research responds to the lack of culturally sensitive care for lesbians and more specifically lesbian couples. The purpose of this study is to explore the meaning that the lesbian couple relationship has for the lesbian couple and how this relationship contributes to their mutual and individual sense of health. A phenomenological feminist approach captured a rich description of the lived experiences of lesbian couples, all of whom were middle class, Caucasian and well educated. Purposive sampling garnered seven lesbian couples. Two flexible, minimally structured interviews were conducted with each couple. Increased knowledge of lesbian couple relationships as a resource for the women's sense of health, will help care professionals use health support systems for lesbians and ease the burden of oppression. (Abstract shortened by UMI.)
Chemoenzymatic Synthesis of 13-Oxoverruculogen
Creators: name: Cohen, Gabriel L
Publisher: name: Brandeis University
Year: 2024

description: The high reactivity of endoperoxide moieties poses significant challenges for the synthesis of endoperoxide-containing natural products. To overcome this challenge, enzymes from the biosynthetic pathway can be used in vitro to form the endoperoxide moiety in a single step. The enzyme FtmOx1 is known to form the 8-membered endoperoxide ring in vivo for the natural product 13-oxoverruculogen and can be utilized in a synthesis pathway.  This study presents the chemoenzymatic synthesis pathway for 13-oxoverruculogen, focusing on the key enzymatic step, subsequent oxidation, and mechanistic studies. This synthetic approach facilitates the production of 13-oxoverruculogen, a potential anti-cancer agent, and enables further mechanistic studies on the enzyme FtmOx1.
Désir, temporalité et création : de l'artifice étatique dans la pensée politique de Thomas Hobbes.
Creators: name: Morin, Patrick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Political Science, General.

description: Pour quiconque s'intéresse à l'État moderne, la question de ses fondements est incontournable. Le présent travail analyse la pensée politique de Thomas Hobbes, penseur capital de la modernité, en insistant principalement sur les relations qu'entretiennent les concepts de désir et de temporalité avec l'édification de l'État. En partant de la vision mécaniste de Hobbes faisant de l'homme un être dont le mouvement est désir, l'étude illustre les répercussions sociales et politiques qu'engendrent les limites temporelles de son univers, axées sur un rapport de continuité et de discontinuité de la vie. C'est particulièrement en explicitant les antinomies qui jonchent la pensée de Hobbes (désir/raison, continuité/discontinuité, nature/artifice, liberté/nécessité) et qui viennent poser les fondements bio-psychologiques de l'artifice étatique, qu'il apparaît possible d'expliquer à la fois la nécessité, l'absolutisme et la permanence de l'État dans l'ère moderne, mais aussi les principes de son dépassement, faisant de Hobbes un penseur important de la modernité, mais surtout un penseur essentiel à la compréhension actuelle de l'État et de ses mécanismes.
MAPPING THE DYNAMICS OF EPIGENETIC ADAPTATION
Creators: name: Larkin, Ajay
Publisher: name: Brandeis University
Year: 2026
Subjects: Adaptation
Clr4
histone methylation
S.pombe
Cellular biology
Epigenetics

description: Chromatin packages DNA inside eukaryotic nuclei, and the organization of chromatin governs the expression of packaged genes. Chromatin packaging confers latent adaptive epigenetic potential to cells. Pathogenic fungi and cancer can adapt to chemical threats or other adversities by restructuring chromatin accessibility to rewire gene expression. However, although we have many documented cases of chromatin remodeling in response to stress, we know very little about how this rapid and reversible adaptive strategy is implemented by cells over time. This complicates drug and treatment development when opposed with epigenetic transcriptional plasticity, necessitating understanding of this adaptive strategy in an ever-evolving arms race.Here, we construct a system devised to track the process of adaptive chromatin remodeling by using the model fission yeast, S.pombe, which redistributes the histone modification, H3K9 methylation (H3K9me), to repress gene expression to adapt to stress. Our unique precision-engineered system triggers population-wide epigenetic adaptation, revealing changes that lead to the formation of novel epigenetic adaptations over a five-day period. We show that, prior to adaptation, cells enter a slow-growth, stress response state. This is paired with the transient silencing of essential genes, which together form a state permissive for the nucleation of novel adaptive H3K9me.
description: Next, because epigenetic adaptations are reversible, we leveraged our system to remove stress to test reversibility and memory of adaptive H3K9me. We observed that, in previously adapted cells that were allowed to recover, adaptively silenced genes were quickly re-expressed. Upon reapplication of stress, there was a period of 6-8 cell divisions that allowed for the rapid return of adaptive H3K9me without reentry to the slow-growth state. By implementing genetic deletions that extend the retention of H3K9me, we are able to show that H3K9me is sufficient to retain adaptive memory in recovering cells. We uncouple H3K9me from adaptive gene silencing, which is possibly dependent on addition factors, including unique transcriptional states.
description: Lastly, we build from the foundation set by this work to further interrogate the mechanisms of adaptive H3K9me nucleation through a series of targeted deletions. These experiments serve to address several possible models for how cells nucleate novel adaptive H3K9me. We also expand our system to reduce the cost of future investigations using single-cell experiments to address questions of adaptive choice and rare sub-population formation. Overall, this work serves to set a foundation for constructing further understanding of adaptive epigenetic chromatin reorganization.
Seismic evaluation of existing reinforced concrete bridges in Ottawa region
Creators: name: Bayani Keivani, Shahram
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Civil.

description: Many existing bridges, especially those built before 1970, were designed with minimum or no seismic considerations. Past experience has shown that such bridges are very vulnerable when subjected to moderate and strong earthquake motions. This was illustrated during the 1989 Loma Prieta, the 1994 Northridge, and the 1995 Kobe earthquakes, when many existing bridge collapsed or were severely damaged. Such a poor performance of the bridges was attributed primarily to the fact that the seismic effects were underestimated in the pre-1970's design practice. In Ottawa region, a great expansion of highway bridges occurred in the 1950's to 1970's, before modern bridge design codes were developed. Statistics show that the number of existing bridges designed according to substandard seismic codes is significantly larger than the number of new, well-designed bridges. Given this, it is essential to develop methods for evaluation and retrofit of existing bridges in order to reduce the risk from seismic actions. In this study, seismic evaluation was conducted to eight bridges located in the Ottawa region and designed according to the pre-1970's bridge codes. In addition, one new bridge, built 1994, was analyzed and was used as a reference case for comparing the performance of older and new bridges. Inelastic models were developed for each bridge and nonlinear dynamic analyses were conducted by using excitation motions compatible with the design spectrum for Ottawa, prescribed by the latest Canadian national code for bridge design. The performance of the bridges was assessed by analyzing the responses represented by curvature ductilities, shear demands, and lateral drifts. The results indicated that the performance of most of the selected bridges is acceptable for the seismic excitations used in this study.
No Roadmap? No Problem: First-Generation Students’ Cultural Assets and the Path to Undergraduate Success
Creators: name: Monroe, Nicholas
Publisher: name: Brandeis University
Year: 2023
Subjects: Agency
Assets-Based Approach
Cultural Assets
Cultural Capital
First-generation college students
Social class
College Students

description: This research explores the relationship between cultural capital, agency, and the successful navigation of college. Drawing from my analysis of 59 semi-structured interviews with graduates of a highly selective four-year private college, I compare the undergraduate experiences of first-generation and continuing-generation graduates. Existing research mostly frames first-generation students as those who generally lack the tools, skills, and resources for undergraduate success. To the contrary, my dissertation convincingly shows that first-generation students employ a trove of personal, family, and cultural resources to successfully navigate college. Focusing on the relationship between cultural capital and the effective navigation of college, my findings show that dominant cultural capital provides situational advantages, while its absence is only contextually disadvantageous. Another key finding is that, among the first-generation graduates in this study, non-dominant cultural capital proved to be a valuable asset for navigating college. In addition, I show that agency can play a significant role in achieving upward mobility and that cultural capital can be strategically deployed to achieve a desired future state. Furthermore, my analysis demonstrates that there is considerable intra-class heterogeneity among middle- and working-class families, suggesting that social class categories are fluid, porous, and fail to reflect the economic fluctuations of lived experience. At its core, my dissertation aims to advance a paradigmatic shift away from deficit-based research focused on what students lack and towards a model that reflects the educationally relevant personal, family, and cultural assets possessed by first-generation, lower income, and other marginalized students.
Leaving Christianity: How Morality and Personal Autonomy is Leading Young Adults to Become Religiously Unaffiliated
Creators: name: Self, Angela Rose
Publisher: name: Brandeis University
Year: 2022
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Christianity
subject: Comparative Religion
subject: LGBTQ Studies
subject: Women's Studies

description: This senior thesis analyzes why young adults in the United States are disaffiliating with organized Christianity and becoming religiously unaffiliated. The rise of a morality that values personal autonomy along with the decline of religious participation is proposed to be one of the reasons as to why this phenomenon is occurring. As religious affiliation effects political views, this could have long lasting consequences for citizens in the United States.
Software documentation: Building and maintaining artefacts of communication.
Creators: name: Forward, Andrew.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Computer Science.

description: Software documentation is an important aspect of both software projects and software engineering in general. In fact, documentation engineering has become a popular sub-domain in the software engineering community. Unfortunately, the current perception of documentation is that it is outdated, irrelevant and incomplete. For the most part, this perception is probably true. Regrettably, the documentation concern cannot be resolved by simply mandating more and better documentation. This approach fails to resolve the problem as the solution ignores the fundamental goals of software engineering. The role of documentation in a software engineering environment is to communicate information to its audience and instill knowledge of the system it describes. Documentation should efficiently allow for future software development without hindering current progress. An engineered solution to the documentation problem would involve allocating appropriate resources to document adequate knowledge about the system to the extent that both current and future development will optimally benefit. Unfortunately, neither do we fully understand the impact of documentation on current or future development, nor what aspects of documentation contribute to its ability to communicate effectively. We do not really know to what extent we should document in order to balance the trade offs between, on the one hand, allocating too many resources for documentation thus hindering present development; and, on the other hand, not allocating enough resources and thus hindering future development. To complicate matters, increasing documentation resources does not necessarily improve future software development (the ultimate goal of documentation) because we do not really understand what defines documentation quality. Our research focuses on the issue of documentation quality. In particular, which attributes of documentation make it effective to the audience and how can this information be monitored and parameterized to provide a better perspective about the relevance of documentation in a software project.
A message from the past: Past temporal reference in early African American letters.
Creators: name: Van Herk, Gerard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Language, Linguistics.

description: This study employs the methods of comparative and variationist linguistics in a new data source, letters by semiliterate 19th-century Liberian immigrants, to confirm and extend the findings of earlier studies on the past temporal reference system of Early African American English (AAE). In the first half of the study, the strongest linguistic constraints on the choice of bare verb forms match precisely those described for large-scale studies of spoken (diaspora) Early AAE: the bare form results from consonant cluster simplification in weak verbs, and from lexical preferences attested through the history of English in the case of strong verbs. Conditioning factors proposed to result from earlier creole influence on Early AAE (anteriority, remoteness, or clause type) did not play a significant role. The second half of the study concerns multiple verb forms, especially the present perfect, described by previous studies as marginal or non-existent in AAE. In contrast, present perfect forms in this corpus are frequent and favoured by all the English-derived conditioning factors tested in this study: ambiguity of temporal orientation and relation, recent or continuing events, negation, extended time adverbials, and since clauses, as well as by non-statives. This conditioning, especially taken in concert with the variability of bare verb forms, suggests that the present perfect has long been part of AAE, with its rarity in other corpora due to genre-based differences in the frequency of contexts requiring its use. The study provides new evidence in the history of the development of African American varieties of English, as well as demonstrating the utility of variationist analysis in resolving problems of linguistic system membership. Combining variationist and comparative analytical methods, it places AAE within the context of the development of the English language.
Exploring the strategies that midwives in British Columbia use to promote normal birth
Creators: name: Butler, Michelle M
Publisher: name: BioMed Central
Year: 2017

description: Background: Rates of normal birth have been declining steadily over the past 20 years, despite the evidence of the benefits to mother and baby. This is most obvious in steadily increasing caesarean section rates across countries and studies of the factors involved suggest it may be more to do with the organization of maternity care and the preferences of healthcare providers than changes in maternal or demographic conditions. The proportion of women in British Columbia (BC) receiving care from a midwife continues to grow and there is a particular focus on promoting and supporting normal pregnancy and birth in the midwifery philosophy of care. In BC, women receiving care from a midwife are less likely to have a caesarean section and other birth interventions. Methods: An interpretive approach, based on interpretive phenomenology was used to explore the experiences of midwives in BC of normal birth and the strategies that they use to keep birth normal. Fourteen experienced midwives were purposively selected from across the range of practice, geographical, and rural/urban contexts to participate in depth interviews. Data were analyzed using Thematic Network Analysis. Results: Seven key themes were identified in the data: working with women from the early pregnancy, informing choice, the birth environment, careful watching and waiting, managing early labour, helping the woman to cope with labour, and tools in the tool kit. Conclusions: Midwives in BC work closely with women from early pregnancy to prepare them for a normal birth, and as “instruments of care” they adopt a range of approaches to support women to achieve this. The emphasis on continuity of care in the BC model of midwifery care plays a vital role in this.
Draft genome sequence of Leifsonia sp. strain NCR5, a rhizobacterium isolated from cadmium-contaminated soil
Creators: name: Egidi, Eleonora
name: Wood, Jen
name: Fox, Edward M.
name: Liu, Wuxing
name: Franks, Ashley E.
Publisher: name: Swinburne
Year: 2024

description: We report here the draft genome sequence of Leifsonia sp. strain NCR5, a Gram-positive actinomycete isolated from Carpobrotus rossii (Haw.) Schwantes rhizosphere. The de novo genome of Leifsonia sp. strain NCR5 was assembled with 69 scaffolds and a G+C content of 69%, was 4.2 Mb in length, and contained 3,952 coding sequences.
MIAS (executable)
Creators: name: Ning, Jing
name: Li, Zhou
name: Zhang, Xingjiang
name: Wang, Junlong
name: Chen, Dandan
name: Liu, Qiong
name: Shao, Yefeng
name: Sun, Yi
Publisher: name: figshare
Year: 2022
Subjects: Neuroscience

description: This compressed package contains all essential components for running Multiplex image acquisition system (MIAS).
 These include: MIAS executable files for Basler, DaHeng, FLIR and HIKVISION cameras; drivers from the supported vendors; an example video recorded with MIAS.
The synthesis, Characterization, and Reactivity of First-Row Late Transition Metal Complexes Containing Tridentate Pincer-Type N-Heterocyclic Phosphenium Ligands
Creators: name: Knight, Sadie E.
Publisher: name: Brandeis University
Year: 2015
Subjects: ligand
coordination
transition metal
synthesis
NHP
phosphenium

description: First-row late transition metal complexes featuring N-heterocyclic phosphine- and phosphenium-containing tridentate pincer ligands have been synthesized and their reactivity has been investigated. The coordination chemistry of a diphosphine pincer ligand incorporating an N-heterocyclic phosphenium cation ([PPP]+) and its halophosphine precursors ([PP(X)P] has been explored using cobalt(II), iron(II) and copper(I) reagents. Treatment of CoCl2 with [PP(Cl)P] led to the neutral coordination complex [PP(Cl)P]CoCl2, which led to the fluoride-abstracted species [PP(F)P]CoCl2 upon exposure to AgPF6 instead of forming a phosphenium-cobalt species. This behavior highlights the electrophilic nature of the [PPP]+ ligand within a [(PPP)CoCl2][PF6] intermediate. \r When the [PP(X)P] precursors were treated with copper(I) halides, simple [PP(X)P]CuY coordination compounds formed (X and Y = Cl or I). The iodophosphine-copper complex [PP(I)P]CuI was shown to react with THF, resulting in a ring-opening insertion to form the alkoxyphosphine complex [PP(O-CH2CH2CH2CH2-I]CuI, a behavior that was also observed for iron species. Reacting the halide-free phosphenium ligand [PPP][BPh4] with CuCl led to [PP(Ph)P]CuCl, the product of phenyl group abstraction from [BPh4]- by the electrophilic phosphenium-copper intermediate species, [(PPP)CuCl][BPh4]. Arylphosphine products [PP(Mes)P]CuCl and [(PP(Mes)P)-Cu][BArF20] were obtained via transmetallation between starting materials and mesityl migration, respectively. Treatment of CuCl with [PPP][BArF20] led to the dimerization product [(PP(Cl)P-Cu)2][BArF20]. Preliminary density functional theory (DFT) calculations suggest that [(PP(Cl)P-Cu)2][BArF20] resulted from the coupling of cationic chlorophosphine- and phosphenium-copper monomer intermediates.\r Finally, a new tridentate hemilable mixed-donor ligand containing a central cationic N-heterocyclic phosphenium donor with a rigid phenylene backbone flanked by two ethylenepyridine side arms ([NPN]+) was synthesized. Using DFT methods, it was shown that [NPN]+ was less electrophilic and a weaker π-acceptor than [PPP]+. The coordination chemistry of the phosphenium precursor ([NP(Cl)N]) with a Pd(PPh)3 resulted in a trimetallic NHP-bridged complex [NPN]2Pd3(PPh3)3Cl2, where the pyridyl groups do not take part in any coordination. Structural and theoretical studies suggest an NHP+ phosphenium description for the μ-NHP units, bound to zero valent palladium centers. Formation of diamagnetic species [NP(Cl)N]CuCl occurs upon treatment of CuCl with [NP(Cl)N], while the reaction between [NPN][BArF20] and CuCl yields a paramagnetic product, proposed to be either [(NPN)CuICl][BArF20] or diradical [(NPN)CuIICl][BArF¬20].
Subjective and objective assessment of physical activity in multiple sclerosis and their relation to health-related quality of life
Creators: name: Krüger, Theresa
name: Behrens, Janina R.
name: Grobelny, Anuschka
name: Otte, Karen
name: Mansow-Model, Sebastian
name: Kayser, Bastian
name: Bellmann-Strobl, Judith
name: Brandt, Alexander U.
name: Paul, Friedemann
name: Schmitz-Hübsch, Tanja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Physical activity
subject: Accelerometry
subject: IPAQ
subject: Multiple sclerosis
subject: Quality of life
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Physical activity (PA) is frequently restricted in people with multiple sclerosis (PwMS) and aiming to enhance PA is considered beneficial in this population. We here aimed to explore two standard methods (subjective plus objective) to assess PA reduction in PwMS and to describe the relation of PA to health-related quality of life (hrQoL). Methods PA was objectively measured over a 7-day period in 26 PwMS (EDSS 1.5–6.0) and 30 matched healthy controls (HC) using SenseWear mini® armband (SWAmini) and reported as step count, mean total and activity related energy expenditure (EE) as well as time spent in PA of different intensities. Measures of EE were also derived from self-assessment with IPAQ (International Physical Activity Questionnaire) long version, which additionally yielded information on the context of PA and a classification into subjects’ PA levels. To explore the convergence between both types of assessment, IPAQ categories (low, moderate, high) were related to selected PA parameters from objective assessment using ANOVA. Group differences and associated effect sizes for all PA parameters as well as their relation to clinical and hrQoL measures were determined. Results Both, SWAmini and IPAQ assessment, captured differences in PA between PwMS and HC. IPAQ categories fit well with common cut-offs for step count (p = 0.002) and mean METs (p = 0.004) to determine PA levels with objective devices. Correlations between specifically matched pairs of IPAQ and SWAmini parameters ranged between r .288 and r .507. Concerning hrQoL, the lower limb mobility subscore was related to four PA measures, while a relation with patients’ report of general contentment was only seen for one. Conclusions Both methods of assessment seem applicable in PwMS and able to describe reductions in daily PA at group level. Whether they can be used to track individual effects of interventions to enhance PA levels needs further exploration. The relation of PA measures with hrQoL seen with lower limb mobility suggests lower limb function not only as a major target for intervention to increase PA but also as a possible surrogate for PA changes.
Microorganisms in heavy metal bioremediation: strategies for applying microbial-community engineering to remediate soils
Creators: name: Wood, Jen
name: Liu, Wuxing
name: Tang, Caixian
name: Franks, Ashley E.
Publisher: name: Swinburne
Year: 2024

description: The remediation of heavy-metal-contaminated soils is essential as heavy metals persist and do not degrade in the environment. Remediating heavy-metal-contaminated soils requires metals to be mobilized for extraction whilst, at the same time, employing strategies to avoid mobilized metals leaching into ground-water or aquatic systems. Phytoextraction is a bioremediation strategy that extracts heavy metals from soils by sequestration in plant tissues and is currently the predominant bioremediation strategy investigated for remediating heavy-metal-contaminated soils. Although the efficiency of phytoextraction remains a limiting feature of the technology, there are numerous reports that soil microorganisms can improve rates of heavy metal extraction.
This review highlights the unique challenges faced when remediating heavy-metal-contaminated soils as compared to static aquatic systems and suggests new strategies for using microorganisms to improve phytoextraction. We compare how microorganisms are used in soil bioremediation (i.e. phytoextraction) and water bioremediation processes, discussing how the engineering of microbial communities, used in water remediation, could be applied to phytoextraction. We briefly outline possible approaches for the engineering of soil communities to improve phytoextraction either by mobilizing metals in the rhizosphere of the plant or by promoting plant growth to increase the root-surface area available for uptake of heavy metals. We highlight the technological advances that make this research direction possible and how these technologies could be employed in future research.