cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats
Creators: name: Al-Rasheed, Nawal M.
name: Al-Rasheed, Nouf M.
name: Hasan, Iman H.
name: Al-Amin, Maha A.
name: Al-Ajmi, Hanaa N.
name: Mohamad, Raeesa A.
name: Mahmoud, Ayman M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was induced by intraperitoneal injection of streptozotocin and both control and diabetic rats received simvastatin for 90 days. Diabetic rats showed significant cardiac hypertrophy, body weight loss, hyperglycemia, and hyperlipidemia. Serum creatine kinase MB (CK-MB) and troponin I showed a significant increase in diabetic rats. Simvastatin significantly improved body weight, attenuated hyperglycemia and hyperlipidemia, and ameliorated CK-MB and troponin I. Simvastatin prevented histological alterations and deposition of collagen in the heart of diabetic animals. Lipid peroxidation and nitric oxide were increased in the heart of diabetic rats whereas antioxidant defenses were decreased. These alterations were significantly reversed by simvastatin. In addition, simvastatin decreased serum inflammatory mediators and expression of NF-κB in the diabetic heart. Cardiac caspase-3 was increased in the diabetic heart and decreased following treatment with simvastatin. In conclusion, our results suggest that simvastatin alleviates DCM by attenuating hyperglycemia /hyperlipidemia-induced oxidative stress, inflammation, and apoptosis.
Decarbonization and Conflict Resolution: Implications for the Clean Energy Transition
Creators: name: Spatz, Benjamin
name: Sarkar, Aditya
name: De Waal, Alex
Publisher: name: University of Edinburgh
Year: 2023
Subjects: Peace Processes

description: This policy brief outlines a new, and nuanced, relationship among conflict, peacemaking, and natural resources (particularly oil) in violent, transactional political systems (i.e., political marketplaces), describing how the availability of discretionary oil rents impacts patterns of peacemaking; there are more comprehensive peace deals when there is more oil revenue, and more limited deals such as ceasefires when that revenue decreases. Decarbonization – replacing fossil fuels with “cleaner” non-hydrocarbon-based forms of energy – carries a previously unidentified set of risks in certain contexts: “it may be the loss of oil that causes conflict” (Pospisil 2021). Transitioning away from fossil fuels would eliminate oil revenue as a ready source of political finance, which risks upsetting the associated elite deals unpinned in precisely the contexts where governments are least well-equipped to manage the transition. This has implications for stability, violence, peacemaking, corruption, development and humanitarian outcomes.
Leptin Raises Defended Body Temperature without Activating Thermogenesis
Creators: name: Fischer, Alexander W.
name: Hoefig, Carolin S.
name: Abreu-Vieira, Gustavo
name: Jong, Jasper M. A. De
name: Petrovic, Natasa
name: Mittag, Jens
name: Cannon, Barbara
name: Nedergaard, Jan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.
title: Data set: Measurements of the positive sequence impedance of eleven measurement sites from 2016 to 2024
title: Datensatz: Messungen der Mitsystem-Impedanz von elf Messstandorten zwischen 2016 und 2024
titleType: AlternativeTitle
Creators: name: Schräder, Johannes
name: Meyer, Marc Florian
name: Jordan, Michael
Publisher: name: UB HSU
Year: 2024
Subjects: subject: Grid impedance measurement
subject: Grid impedance
subject: Data set
subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten

description: The data sets are .csv files. Each row contains a single impedance measurement, consisting of the measurement time and the measurement result of the complex positive sequence Impedance from 50 Hz to 100 kHz with a stepsize of 50 Hz. These measurement stem from several measurement campaigns conducted within the scope of three research projects. These measurement campaigns were founded in course of the research projects "NetzHarmonie" (support code: 0325757F), "NEW 4.0" (support code: 03SIN414) and "ImaStabil" (support code: 03EI4060C).
description: These data sets contain all exhibited positive sequence impedance measurement outcomes presented in the paper "Survey of Harmonic Grid Impedance Measurements on the Medium Voltage Level up to 100 kHz" from the measurement sites A-K. Metadata regarding the measurement sites can be found in the paper.
The Partnership for Global Infrastructure and Investment (PGII) and the Belt and Road Initiative (BRI): Meeting the World's Infrastructure Gaps amid Geopolitical Competition
Creators: name: Mariani, Bernardo
Publisher: name: University of Edinburgh
Year: 2023
Subjects: Global Transitions
China
Global

description: In 2022, the U.S. and the other members of the G7 launched the Partnership for Global Infrastructure and Investment (PGII), a collaborative initiative that aims to raise $600 billion for global infrastructure projects in emergent nations. While the PGII has potential to support global growth trajectories and development plans for low and medium-income countries, it is also intended to counter China’s growing influence, resultant of its Belt and Road Initiative (BRI). China and the G7 nations share common interests in meeting global infrastructure development needs, but these run parallel to both actors’ concerns in advancing their own geopolitical goals. This brief outlines how recipient countries can engage with and benefit from the BRI and/or the PGII, and highlights scope for collaboration between the implementing organisations for both initiatives. The Global Transitions Series looks at fragmentations in the global order and how these impact peace and transition settlements. It explores why and how different third-party actors – state, intergovernmental, and non-governmental – intervene in conflicts, and how they see themselves contributing to reduction of conflict and risks of conflict relapse. The series critically assesses the growth and diversification of global and regional responses to contemporary conflicts. It also asks how local actors are navigating this multiplicity of mediators and peacebuilders and how this is shaping conflict outcomes and post-conflict governance.
Sino-European relations amid the war in Ukraine
Creators: name: Mariani, Bernardo
Publisher: name: University of Edinburgh
Year: 2022
Subjects: Global Transitions
China
Ukraine

description: The war in Ukraine is redefining global geopolitics and is affecting already strained relations between China and Europe. Despite diverse interpretations of the war’s root cause and contested threat perceptions, China and Europe have shared interests; both wish to avoid escalation of the conflict, manage the fall-out of the war, and explore options for its resolution. This brief shares key findings and recommendations for Sino-European cooperation, communication, and management of repercussions of Russia’s war on Ukraine. The Global Transitions Series looks at fragmentations in the global order and how these impact peace and transition settlements. It explores why and how different third-party actors – state, intergovernmental, and non-governmental – intervene in conflicts, and how they see themselves contributing to reduction of conflict and risks of conflict relapse. The series critically assesses the growth and diversification of global and regional responses to contemporary conflicts. It also asks how local actors are navigating this multiplicity of mediators and peacebuilders and how this is shaping conflict outcomes and post-conflict governance.
Supplementary document for Atmospheric Correction in Coastal Region Using Same-day Observations with Different Sun-sensor Viewing Geometries - 4750698.pdf
Creators: name: Wang, Junwei
name: Lee, Zhongping
name: Wei, Jianwei
name: Du, Keping
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Information
Summary of Publications and Research Relevant to the Post-Earthquake Context
Creators: name: PeaceRep Syria Research Team
Publisher: name: University of Edinburgh
Year: 2023
Subjects: Concepts
Syria
Turkey

description: The high level of destruction and subsequent needs in the wake of the catastrophic earthquake that hit Southern Turkey and Syria on the 6 February 2023 have brought several important questions about Syria-related polices to the surface. These include questions relating to early recovery in both government controlled areas and North West Syria, the politics of reconstruction, sanctions, and the role of the private sector and civil society. The Syria research group based at LSE IDEAS has produced several policy papers over recent years, many of which can speak to issues being discussed in the post-earthquake context and offer answers to important questions that are being posed on all levels. The team are currently redrafting a future research agenda for the post-earthquake era. This digest points to the most relevant policy papers offering insights into questions on political, economic and social responses and implications of the earthquake. References signpost the reader towards relevant sections of each publication, and provide context for its linkage to the current situation.
Terminal spreading depolarization and electrical silence in death of human cerebral cortex
Creators: name: Dreier, Jens P.
name: Major, Sebastian
name: Foreman, Brandon
name: Winkler, Maren K. L.
name: Kang, Eun-Jeung
name: Milakara, Denny
name: Lemale, Coline L.
name: DiNapoli, Vince
name: Hinzman, Jason M.
name: Woitzik, Johannes
name: Andaluz, Norberto
name: Carlson, Andrew
name: Hartings, Jed A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: cerebral ischemia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Objective: Restoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could help predict the time available for resuscitation until irreversible damage and advance development of interventions that prolong this span. Experimentally, injury to central neurons begins only with anoxic depolarization. This potentially reversible, spreading wave typically starts 2 to 5 minutes after the onset of severe ischemia, marking the onset of a toxic intraneuronal change that eventually results in irreversible injury. Methods: To investigate this in the human brain, we performed recordings with either subdural electrode strips (n = 4) or intraparenchymal electrode arrays (n = 5) in patients with devastating brain injury that resulted in activation of a Do Not Resuscitate–Comfort Care order followed by terminal extubation. Results: Withdrawal of life‐sustaining therapies produced a decline in brain tissue partial pressure of oxygen (ptiO2) and circulatory arrest. Silencing of spontaneous electrical activity developed simultaneously across regional electrode arrays in 8 patients. This silencing, termed “nonspreading depression,” developed during the steep falling phase of ptiO2 (intraparenchymal sensor, n = 6) at 11 (interquartile range [IQR] = 7–14) mmHg. Terminal spreading depolarizations started to propagate between electrodes 3.9 (IQR = 2.6–6.3) minutes after onset of the final drop in perfusion and 13 to 266 seconds after nonspreading depression. In 1 patient, terminal spreading depolarization induced the initial electrocerebral silence in a spreading depression pattern; circulatory arrest developed thereafter. Interpretation: These results provide fundamental insight into the neurobiology of dying and have important implications for survivable cerebral ischemic insults. Ann Neurol 2018;83:295–310
Data from: Sustained intestinal epithelial monolayer wound closure after transient application of a FAK-activating small molecule
Creators: name: Basson, Marc
Publisher: name: Zenodo
Year: 2024
Subjects: Focal Adhesion Kinase
duration of action
extended signaling
cell migration.

description: M64HCl, which has drug-like properties, is a water-soluble Focal Adhesion Kinase (FAK) activator that promotes murine mucosal healing after ischemic or NSAID-induced injury. Since M64HCl has a short plasma half-life in vivo (less than two hours), it has been administered as a continuous infusion with osmotic minipumps in previous animal studies. However, the effects of more transient exposure to M64HCl on monolayer wound closure remained unclear. Herein, we compared the effects of shorter M64HCl treatment in vitro to continuous treatment for 24 hours on monolayer wound closure. We then investigated how long FAK activation and downstream ERK1/2 activation persist after two hours of M64HCl treatment in Caco-2 cells. M64HCl concentrations immediately after washing measured by mass spectrometry confirmed that M64HCl had been completely removed from the medium while intracellular concentrations had been reduced by 95%. Three-hour and four-hour M64HCl (100 nM) treatment promoted epithelial sheet migration over 24 hours similar to continuous 24-hour exposure. 100nM M64HCl did not increase cell number. Exposing cells twice with 2-hr exposures of M64HCl during a 24-hour period had a similar effect. Both FAK inhibitor PF-573228 (10 µM) and ERK kinase (MEK) inhibitor PD98059 (20 µM) reduced basal wound closure in the absence of M64HCl, and each completely prevented any stimulation of wound closure by M64HCl. Rho kinase inhibitor Y-27632 (20 µM) stimulated Caco-2 monolayer wound closure but no further increase was seen with M64HCl in the presence of Y-27632. M64HCl (100 nM) treatment for 3 hours stimulated Rho kinase activity.  M64HCl decreased F-actin in Caco-2 cells. Furthermore, a two-hour treatment with M64HCl (100 nM) stimulated sustained FAK activation and ERK1/2 activation for up to 16 and hours 24 hours, respectively. These results suggest that transient M64HCl treatment promotes prolonged intestinal epithelial monolayer wound closure by stimulating sustained activation of the FAK/ERK1/2 pathway. Such molecules may be useful to promote gastrointestinal mucosal repair even with a relatively short half-life.
description: Funding provided by: National Institutes of HealthROR ID: https://ror.org/01cwqze88Award Number:
Supplementary document for Atmospheric Correction in Coastal Region Using Same-day Observations with Different Sun-sensor Viewing Geometries - 4750698.pdf
Creators: name: Wang, Junwei
name: Lee, Zhongping
name: Wei, Jianwei
name: Du, Keping
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental Information
Transition à la pratique de l'infirmière praticienne francophone diplomée
Creators: name: Laflamme, Célyne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Nursing.

description: Buts: En utilisant l'ethnographie ciblée, cette recherche qualitative cherche à comprendre l'expérience de la transition à la pratique des infirmières praticiennes (IP) francophones diplômées, de leur propre perspective et de celle d'un coparticipant (CP) choisi par l'infirmière praticienne. Cette recherche cherche aussi à explorer les besoins de soutien de ces IP au cours de leur première année de pratique en soins de santé primaires et à identifier les besoins particuliers des IP francophones pour dispenser des services de santé en français dans un contexte minoritaire. Méthodes: Des entrevues en profondeur, de type ouvert, par téléphone, ont été effectuées a trois intervalles de temps (trois mois, six mois et douze mois) auprès d'un groupe de six infirmières praticiennes et de leurs six coparticipants désignés. Cette recherche vise les IP francophones, diplômées en 2006, du programme francophone du Consortium ontarien de formation des infirmières et infirmiers praticiens en soins de sante primaires et qui, au moment de l'enquête, travaillaient à titre d'infirmière praticienne dans un milieu de soins de sante primaires en Ontario ou au Manitoba. La revue de la documentation fournie par l'IP, notamment l'organigramme, la description de tâches et les documents de politique ont servi à comprendre le contexte organisationnel. Résultats: Les participants ont décrit une transition comparable à celle décrite par Brown & Olshansky (1997). Les infirmières praticiennes francophones ont évolué à partir d'un sentiment d'inconfort à titre de débutantes dans leur nouveau rôle, vers un sentiment de confiance envers leurs habiletés, tout en cherchant à élargir leur perspective professionnelle vers la fin de leur première année de pratique. Dans l'ensemble, la familiarité avec le milieu de travail et le soutien important fourni par les employeurs ont contribué à produire une expérience positive de la transition. La contribution essentielle de cette étude est résumée dans une liste de quinze recommandations qui servent de stratégie de base pour une transition réussie. Cette recherche contribue à la compréhension des expériences et des besoins de soutien des infirmières praticiennes francophones diplômées et de leurs employeurs en soins de santé primaires. Elle fournit de l'information pour appuyer la mise en oeuvre d'outils et de ressources qui permettront aux IP francophones de travailler au meilleur de leur capacité; pour appuyer la mise en place d'interventions appropriées qui pourraient appuyer les nouvelles IP dans leur quête a perfectionner leurs connaissances et leurs compétences qui leur permettront de fournir des soins d'excellente qualité.
Umweltrelevanz und Stand der Technik bei Einäscherungsanlagen
Creators: name: Schetter, Gebhard
name: Bittig, Margot
Publisher: name: My University
Year: 2019
Subjects: Stand der Technik
Messdaten
Umweltauswirkung
Quecksilber
Schadstoffemission

description: Um einen Überblick über den Stand der Technik bundesdeutscher Krematorien zu bekommen, wurde eine Situationsanalyse durchgeführt. Sie basiert in einem ersten Schritt auf einer Datenerhebung der Krematorien in den einzelnen Bundesländern. Ergänzend hierzu wurde eine Klassifizierung der eingesetzten technologischen Baugruppen vorgenommen und hinsichtlich der 27. Bundes-Immissionsschutz-Verordnung (27. BImSchV) sowie des Standes der Technik gemäß der VDI-Richtlinie 3891 bewertet. Aufbauend auf der durchgeführten Datenerhebung wurden sechs Kremationslinien mit unterschiedlichen Ofen- und Abgasreinigungssystemen ausgewählt, um sie umfassenden Abgasmessungen zu unterziehen. Die Untersuchungen erstreckten sich auf die Abgasparameter der 27. BImSchV und Quecksilber. Aus den gewonnenen Erkenntnissen wurden Handlungsempfehlungen für zukünftige Entscheidungen des Gesetzgebers abgeleitet, die sowohl auf bereits in der 27. BImSchV enthaltene Anforderungen zur Emissionsminderung als auch auf die Minderung der Quecksilberemissionen abstellen. Quelle: Forschungsbericht
description: In order to get an overview of the state of the art of German crematoria, a situation analysis was carried out. In a first step, it is based on a data collection of the crematoria sorted by the German federal states. In addition, a classification of the installed technologies was carried out and evaluated with regard to the 27th Federal Immission Control Ordinance (27th BImSchV) and the state of the art in accordance with VDI Guideline 3891. Based on the results of the data collection of the crematoria in Germany in total six cremation lines with different oven and flue gas cleaning devices were selected for further emission measurements. These investigations dealt with the emission limitations according to the 27th BImSchV as well as with mercury. From these results policy recommendations were derived for further decisions which are focused on the existing emission values of the 27th BImSchV and on the reduction of mercury emissions. Quelle: Forschungsbericht
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 341 (47. Jg), August 2017
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: 50. Jahrestag der Universität Ulm
subject: Lange Nacht der Wissenschaft
subject: Wissenschaftspreis der Stadt Ulm an Prof. Carsten Streb
subject: 12 Millionen Euro für Peptid-SFB
subject: 30 Jahre Austausch mit Costa Rica
subject: DDC 050 / General serial publications
subject: Universities; Germany; Ulm
subject: Universität Ulm
subject: Wissenschaftspreis

description: uni ulm intern - das Universitätsmagazin mit Themen aus Forschung, Lehre und vom Campus
description: uni ulm intern, Das Ulmer Universitätsmagazin, Heft Nr. 341 (47. Jg.), August 2017
Transcranial direct current stimulation of the primary motor cortex improves word-retrieval in older adults
Creators: name: Meinzer, Marcus
name: Lindenberg, Robert
name: Sieg, Mira M.
name: Nachtigall, Laura
name: Ulm, Lena
name: Flöel, Agnes
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Language facilitation by transcranial direct current stimulation (tDCS) in healthy individuals has generated hope that tDCS may also allow improving language impairment after stroke (aphasia). However, current stimulation protocols have yielded variable results and may require identification of residual language cortex using functional magnetic resonance imaging (fMRI), which complicates incorporation into clinical practice. Based on previous behavioral studies that demonstrated improved language processing by motor system pre-activation, the present study assessed whether tDCS administered to the primary motor cortex (M1) can enhance language functions. This proof-of- concept study employed a sham-tDCS controlled, cross-over, within-subject design and assessed the impact of unilateral excitatory (anodal) and bihemispheric (dual) tDCS in 18 healthy older adults during semantic word- retrieval and motor speech tasks. Simultaneous fMRI scrutinized the neural mechanisms underlying tDCS effects. Both active tDCS conditions significantly improved word-retrieval compared to sham-tDCS. The direct comparison of activity elicited by word-retrieval vs. motor-speech trials revealed bilateral frontal activity increases during both anodal- and dual-tDCS compared to sham- tDCS. This effect was driven by more pronounced deactivation of frontal regions during the motor-speech task, while activity during word-retrieval trials was unaffected by the stimulation. No effects were found in M1 and secondary motor regions. Our results show that tDCS administered to M1 can improve word-retrieval in healthy individuals, thereby providing a rationale to explore whether M1-tDCS may offer a novel approach to improve language functions in aphasia. Functional magnetic resonance imaging revealed neural facilitation specifically during motor speech trials, which may have reduced switching costs between the overlapping neural systems for lexical retrieval and speech processing, thereby resulting in improved performance.
Centrality dependence of the charged particle multiplicity near midrapidity in [Formula Presented] collisions at [Formula Presented] and 200 GeV
Creators: name: Back, B. B.
name: Ballintijn, M.
name: Baker, M. D.
name: Barton, D. S.
name: Betts, R. R.
name: Bickley, A.
name: Bindel, R.
name: Budzanowski, A.
name: Busza, W.
name: Carroll, A.
name: Corbo, J.
name: Decowski, M. P.
name: Garcia, E.
name: George, N.
name: Gulbrandsen, K.
name: Gushue, S.
name: Halliwell, C.
name: Hamblen, J.
name: Heintzelman, G.
name: Henderson, C.
name: Hicks, Damien
name: Hofman, D.
name: Hollis, R. S.
name: Hołyński, R.
name: Holzman, B.
name: Iordanova, A.
name: Johnson, E.
name: Kane, J.
name: Katzy, J.
name: Khan, N.
name: Kucewicz, W.
name: Kulinich, P.
name: Kuo, C. M.
name: Lin, W. T.
name: Manly, S.
name: McLeod, D.
name: Michałowski, J.
name: Mignerey, A.
name: Mülmenstädt, J.
name: Nouicer, R.
name: Olszewski, A.
name: Pak, R.
name: Park, I. C.
name: Pernegger, H.
name: Rafelski, M.
name: Rbeiz, M.
name: Reed, C.
name: Remsberg, L. P.
name: Reuter, M.
name: Roland, C.
name: Roland, G.
name: Rosenberg, L.
name: Sagerer, J.
name: Sarin, P.
name: Sawicki, P.
name: Skulski, W.
name: Steadman, S. G.
name: Steinberg, P.
name: Stephans, G. S.F.
name: Stodulski, M.
name: Sukhanov, A.
name: Tang, J. L.
name: Teng, R.
name: Trzupek, A.
name: Vale, C.
name: van Nieuwenhuizen, G. J.
name: Verdier, R.
name: Wadsworth, B.
name: Wolfs, F. L.H.
name: Wosiek, B.
name: Woźniak, K.
name: Wuosmaa, A. H.
name: Wysłouch, B.
Publisher: name: Swinburne
Year: 2024

description: The PHOBOS experiment has measured the charged particle multiplicity at midrapidity in Au+Au collisions at sqrt[SNN]=200 GeV as a function of the collision centrality. Results on dNch/dη||η|<1;1 divided by the number of participating nucleon pairs 〈Npart〉/2 are presented as a function of 〈Npart〉. As was found from similar data at sqrt[SNN]=130 GeV the data can be equally well described by parton saturation models and two-component fits, which include contributions that scale as Npart and the number of binary collisions Ncoll. We compare the data at the two energies by means of the ratio R200/130 of the charged particle multiplicity for the two different energies as a function of 〈Npart〉. For events with 〈Npart〉> 100, we find that this ratio is consistent with a constant value of 1.14±0.01(stat)±0.05(syst).
Tactile acuity and active joint repositioning sense in individuals with and without chronic low back pain: a cross-sectional study
Creators: name: Rodríguez-Romero, Beatriz
name: Gallo-Marcos, Carla
name: Mancebo-Blanco, Daniel
name: Tuñas-Maceiras, Isabel
name: Silva, Anabela G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Sensorimotor dysfunction, as measured by tactile acuity and active joint repositioning, has been identified as a contributing factor of chronic low back pain (CLBP). Existing research suggests that further research is necessary to improve the characterization of sensorimotor perception in patients with CLBP. The main aim is to investigate whether tactile acuity and repositioning errors differ between individuals with CLBP and controls without CLBP. A secondary aim was to investigate the association between age, body mass index (BMI) and physical activity, and tactile acuity and repositioning sense. Cross-sectional study. Sixty-eight participants (36 with, 32 without CLBP) were examined. Two-Point Discrimination (TPD) test (four measures: horizontal and vertical run, left and right side) and Active Joint Reposition Sense (AJRS) test (2 directions: to flexion and to extension) were used. No differences were found for TPD (right horizontal run: p = .069; left horizontal run: p = .066; right vertical run: p = .933; left vertical run: p = .285) or AJRS (flexion: p = .792; extension: p = .956) between participants with and without CLBP. Older subjects had significantly worse tactile acuity (3 sites, p = .018, p = .004, p = .041) and worse repositioning sense (2 directions, p = .026, p = .040,) than younger subjects. Individuals with BMI ≥ 25 had significantly worse TPD compared to individuals with normal weight (2 sites, p = .028, p = .020). Individuals with CLBP did not have impaired tactile and repositioning accuracy when compared to controls without CLBP. Future studies comparing sensorimotor performance should consider age and BMI as potential confounding factors.
Assessing the reactivity of hard carbon anodes: linking material properties with electrochemical response upon sodium‐ and lithium‐ion storage
Creators: name: Moon, Hyein
name: Zarrabeitia, Maider
name: Frank, Erik
name: Böse, Olaf
name: Enterría, Marina
name: Saurel, Damien
name: Hasa, Ivana
name: Passerini, Stefano
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: hard carbon
subject: solid electrolyte interphase
subject: DDC 540 / Chemistry & allied sciences
subject: Sodium ion batteries
subject: Anodes
subject: Microstructure
subject: Anode
subject: Mikrostruktur

description: The hard carbon puzzle: Linking material properties and electrochemical reactivity of hard carbon anodes in lithium and sodium cells. Hard carbon (HC) is the negative electrode (anode) material of choice for sodium-ion batteries (SIBs). Despite its advantages in terms of cost and sustainability, a comprehensive understanding of its microstructure is not complete yet, thus hindering a rational design of high-performance HC electrodes. In this study, rather than investigating how the precursor and synthesis method influence on the electrochemical properties of HC anodes, we examine the microstructure and surface chemistry of three optimized HC anodes obtained from different precursors by using different synthesis routes. The main goal is to evaluate the influence of the final materials properties (in their optimized state) on the electrochemical reactivity in lithium and sodium cells after a comprehensive structural characterization performed by means of X-ray photoelectron spectroscopy (XPS), wide-angle X-ray scattering (WAXS), Raman spectroscopy, scanning electron microscopy (SEM), and gas sorption measurements. The different electrochemical performance observed in terms of cycling stability and rate capability, and the stability of the solid electrolyte interphase (SEI) formed on the various HCs have been comprehensively investigated. A correlation of the material properties with their electrochemical response upon sodium and lithium uptake and release is clarified. By comparing the Na- and Li-ion storage behavior, a structure-function relation is identified.
Optimizing Surface Micro Grooving to Reduce the Checking and Cupping of Douglas Fir, Western Hemlock and White Spruce Decking Exposed to Natural Weathering
Creators: name: Heshmati, Sina
name: Mazloomi, Mohammad Sadegh
name: Evans, P. D. (Philip D.)
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Machining grooves into the surface of pine and fir (Abies spp.) deckboards reduces undesirable checking that develops when “profiled” boards are exposed to the weather. We aim to develop improved profiles for Douglas fir, western hemlock and white spruce decking to reduce their susceptibility to checking, and understand how profile geometry influences the stresses that cause checking. We varied the width and depth of grooves in profiled deckboards, exposed deckboards to the weather, and measured checking and cupping of boards. A numerical model examined the effect of groove depth on the moisture-induced stresses in profiled spruce boards. Profiling significantly reduced checking, but increased cupping of deckboards made from all three species. Western hemlock checked more than the other two species. Profiles with narrow grooves (rib profiles) were better at restricting checking than profiles with wider grooves. A rib profile with deeper grooves developed smaller stresses than a rib profile with shallower grooves, and boards with the former profile checked less than boards with shallower grooves. We conclude that checking of profiled Douglas fir, western hemlock and white spruce decking is significantly reduced by changing profile geometry, and our results suggest the best profiles to reduce checking of all three species.
Taiwanese university students with hearing impairment: A case study of their experiences and of factors contributing to persistence in their studies
Creators: name: Lee, Shu-Fen Chang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Education, Higher.

description: This study examines the experiences of students with hearing impairment (HI) in a post-secondary institution in Taiwan. The special education law and regulations passed in Taiwan in 1984 concerning the education of students with disabilities led to an increase in the number of students with HI enrolled in post-secondary institutions. Although students with hearing impairment now have greater opportunities to enrol in colleges and universities, and are provided with support services and counselling, they continue to have problems in their academic and social campus life and often eventually drop out (Hsiao, Hsu & Wu, 2(01). However, despite their difficulties, some students with hearing impairment do persist in their studies and graduate. At this point, there is no information on the reasons for these students' success. The purpose of this study is to explore their learning experiences, how they have overcome obstacles, and the factors that led to their persistence in their studies. This study is one of the first qualitative studies to examine the post-secondary experiences of Taiwanese post-secondary students who have hearing impairment. The conceptual model underpinning this study was a revised version of Tinto's 1993 and 1997 Student Integration Model (SIM). The participants were seven students with hearing impairment who were in their third and fourth year of university, their learning partners, four professors, and two personnel for the Centre for Counselling Services. Data collection procedures included individual interviews, focus group interviews, observations, and a self-reflective journal. The interviews were the most important source of data. Profiles of the participants with HI were developed and a cross case analysis was done. The findings identified three factors contributing to persistence: individual characteristics, academic integration and the support services. In terms of academic integration, personal effort in learning was the most important factor, and in terms of the support services, the provision of the learning partners contributed to persistence. Both of these elements helped the students earn higher grades and contributed to persistence. The goal-orientation to graduate and obtain a well-paying, stable job with good benefits was also found to play a vital role in the students' persistence. It also became clear that the students with HI in this study were not well integrated into the social life of the university, and so Tinto's identification of social integration as a factor in persistence was not supported by this study. Therefore, only partial support for Tinto's SIM was found.
Assessing understanding in statistics
Creators: name: Lipson, Kay
Publisher: name: Swinburne
Year: 2024

description: Using a framework for assessing dimensions of understanding in statistics a series of assessment tasks were developed by the researcher to address both procedural and conceptual understanding. This paper describes these tasks, together with the results of students’ performance on the tasks. It will be shown that, while some of the tasks developed did assess the dimension of knowledge which they were developed to address, and some did not, overall it was possible to develop tasks to specifically assess both procedural and conceptual knowledge in statistical inference.
Screening of COPD patients for abdominal aortic aneurysm
Creators: name: Flessenkaemper, Ingo H.
name: Loddenkemper, Robert
name: Roll, Stephanie
name: Enke-Melzer, Kathrin
name: Wurps, Henrik
name: Bauer, Torsten T.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: chronic obstructive pulmonary disease
subject: AAA
subject: screening
subject: risk factors
subject: epidemiology
subject: inflammatory disease
subject: tobacco abuse
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Purpose: Screening for abdominal aortic aneurysm (AAA) in “men aged over 65 years who have ever smoked” is a recommended policy. To reduce the number of screenings, it may be of value to define subgroups with a higher prevalence of AAA. Since chronic obstructive pulmonary disease (COPD) and AAA are associated with several common risk factors, this study investigates the prevalence of AAA in COPD patients. Patients and methods: Patients with COPD were identified via the hospital information system. Inclusion criteria were: COPD stage I–IV, ability to give full consent, and age >18 years; exclusion criteria were: patient too obese for an ultrasound check, previously diagnosed AAA, prior surgery for AAA, or ethical grounds such as concomitant advanced malignant or end-stage disease. The primary endpoint of the study was an aortic diameter measured by ultrasound of ≥30 mm. Defined secondary endpoints were evaluated on the basis of medical records and interviews. Results: Of the 1,180 identified COPD patients, 589 were included in this prospective study. In 22 patients (3.70%), the aortic diameter was ≥30 mm, representing an AAA prevalence of 6.72% among males aged >65 years. The risk of AAA increased with the following comorbidities/risk factors: male sex (odds ratio [OR] 2.98), coronary heart disease (OR 2.81), peripheral arterial occlusive disease (OR 2.47), hyperlipoproteinemia (OR 2.77), AAA in the family history (OR 3.95), and COPD stage I/II versus IV (OR 1.81). Conclusion: The overall AAA prevalence of 3.7% in our group of COPD patients is similar to that of the general population aged >65 years. However, the frequency of AAA in male COPD patients aged >65 years is considerably higher (6.72%) and increased further still in those individuals with additional comorbidities/risk factors. Defining subgroups with a higher risk of AAA may increase the efficiency of screening.
C‐reactive protein flare‐response predicts long‐term efficacy to first‐line anti‐PD‐1‐based combination therapy in metastatic renal cell carcinoma
Creators: name: Klümper, Niklas
name: Schmucker, Philipp
name: Hahn, Oliver
name: Höh, Benedikt
name: Mattigk, Angelika
name: Banek, Severine
name: Ellinger, Jörg
name: Heinzelbecker, Julia
name: Sikic, Danijel
name: Eckstein, Markus
name: Strauß, Arne
name: Zengerling, Friedemann
name: Hölzel, Michael
name: Zeuschner, Philip
name: Kalogirou, Charis
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: checkpoint inhibition
subject: CRP flare‐response
subject: metastatic renal cell carcinoma
subject: DDC 610 / Medicine & health
subject: Immunotherapy
subject: C-reactive protein
subject: Carcinoma, Renal cell
subject: Neoplasm metastasis
subject: Biomarkers
subject: Biomarker
subject: C-reaktives Protein
subject: Immuntherapie
subject: Hypernephrom
subject: Metastase

description: In this multicentre study, we investigated the predictive potential of early serum C‐reactive protein (CRP) kinetics during 1st‐line immunotherapy in metastatic renal cell carcinoma (mRCC). Out of 95 patients with mRCC, those with significant CRP flare‐response or decrease in CRP levels had superior outcomes. This potential biomarker could improve therapy monitoring of mRCC and eventually also treatment stratification. Objectives Immune checkpoint blockade (IO) has revolutionised the treatment of metastatic renal cell carcinoma (mRCC). Early C‐reactive protein (CRP) kinetics, especially the recently introduced CRP flare‐response phenomenon, has shown promising results to predict IO efficacy in mRCC, but has only been studied in second line or later. Here, we aimed to validate the predictive value of early CRP kinetics for 1st‐line treatment of mRCC with αPD‐1 plus either αCTLA‐4 (IO+IO) or tyrosine kinase inhibitor (IO+TKI). Methods In this multicentre retrospective study, we investigated the predictive potential of early CRP kinetics during 1st‐line IO therapy. Ninety‐five patients with mRCC from six tertiary referral centres with either IO+IO (N = 59) or IO+TKI (N = 36) were included. Patients were classified as CRP flare‐responders, CRP responders or non‐CRP responders as previously described, and their oncological outcome was compared. Results Our data validate the predictive potential of early CRP kinetics in 1st‐line immunotherapy in mRCC. CRP responders, especially CRP flare‐responders, had significantly prolonged progression‐free survival (PFS) compared with non‐CRP responders (median PFS: CRP flare‐responder: 19.2 months vs. responders: 16.2 vs. non‐CRP responders: 5.6, P < 0.001). In both the IO+IO and IO+TKI subgroups, early CRP kinetics remained significantly associated with improved PFS. CRP flare‐response was also associated with long‐term response ≥ 12 months. Conclusions Early CRP kinetics appears to be a low‐cost and easy‐to‐implement on‐treatment biomarker to predict response to 1st‐line IO combination therapy. It has potential to optimise therapy monitoring and might represent a new standard of care biomarker for immunotherapy in mRCC.
Supplementary document for Single-cell terahertz spectral characteristics in simulated scattering near-field imaging mode - 4752967.pdf
Creators: name: Wang, Jie
name: Yan, Shihan
name: Li, Zaoxia
name: Zang, Ziyi
name: Lu, Xingxing
name: Cui, Hongliang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
Learning by leading: A qualitative inquiry into the perceived academic, personal, and professional development of PAL study group leaders in physiotherapy education
Creators: name: Christensen, Lene
name: Hilde, Gunvor
name: Eik, Hedda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Peer assisted learning (PAL), where student leaders facilitate their peers’ learning, is prevalent in higher education. However, PAL leaders’ development in physiotherapy education and their role perceptions relating to their future professional practice are understudied. We aimed to understand how PAL leaders in physiotherapy education perceive their own academic learning and personal development, and how they view their experiences as PAL leaders in relation to future physiotherapy practice. Focus group interviews were used to collect qualitative data from third-semester students who had been PAL leaders (n = 19). Data were analyzed using a reflexive, thematic analysis. Three main themes were generated: “Being a PAL leader consolidates knowledge and facilitates new learning,” “Personal growth through experiential learning outside the comfort zone within a community of practice,” and ”Learning by leading – transferability of being a PAL leader to future physiotherapy practice.” Overall, physiotherapy students leading PAL study groups demonstrated academic, personal, and professional growth via experiential learning in a community of practice. They developed skills likely transferable into their future physiotherapy roles. Our findings propose PAL study groups as an arena for PAL leaders to practice complex physiotherapy competences, positioning PAL study groups as valuable preclinical practice for physiotherapy students.
Comparison of habitat characteristics of second- and old-growth forests of the Temagami region of northern Ontario and their relationship to bird abundance.
Creators: name: Jensen, Jill A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Ecology.

description: Logging influences the distribution and abundance of breeding birds by changing the structure and composition of forests. In particular, very little old-growth forest remains. Studies suggest that the structural characteristics of old-growth forests of the Pacific Northwest provide habitat not available in younger forests. This study compared certain characteristics of habitat structure, and abundance of selected bird species in three forest types in the Temagami region of northern Ontario: (i) old-growth pine forests (no history of catastrophic disturbance) (ii) mature pine forests (undisturbed for approx. 100 years) (iii) managed forests (previously pine-dominated and selectively-logged approx. 50 years ago). Canopy height, tree species diversity and percent cover of vegetation in the upper canopy, average number of vegetation layers and spatial variability in the number of layers were all significantly greater in old-growth than in managed or mature forests. Abundances of some bird species were significantly correlated with habitat characteristics. However, none of the bird species censused were significantly more abundant solely in old-growth forests. Our results suggest that vegetation characteristics predict bird abundance more strongly than forest type.
Recursive quantum detector tomography
Creators: name: Zhang, Lijian
name: Datta, Animesh
name: Coldenstrodt-Ronge, Hendrik B.
name: Jin, Xian-Min
name: Eisert, Jens
name: Plenio, Martin B.
name: Walmsley, Ian A.
Publisher: name: Universität Ulm
Year: 2012
Subjects: subject: DDC 530 / Physics
subject: Recursion theory
subject: Rekursionstheorie
subject: Tomografie

description: Abstract Conventional tomographic techniques are becoming increasingly infeasible for reconstructing the operators of quantum devices of growing sophistication. We describe a novel tomographic procedure using coherent states, which begins by reconstructing the diagonals of the operator and then each successive off-diagonal in a recursive manner. Each recursion is considerably more efficient than reconstructing the operator in its entirety, and each successive recursion involves fewer parameters. We apply our technique to reconstruct the positive-operator-valued measure corresponding to a recently developed coherent optical detector with phase sensitivity and number resolution. We discuss the effect of various parameters on the reconstruction accuracy. The results show the efficiency of the method and its robustness to experimental noise.
title: Trends and patterns in surface water chemistry in Europe and North America between 1990 and 2016, with particular focus on changes in land use as a confounding factor for recovery
title: Trends and patterns in surface water chemistry in Europe and North America between 1990 and 2016, with particular focus on changes in land use as a confounding factor for recovery
titleType: AlternativeTitle
Creators: name: Arle, Jens
name: Garmo, Øyvind Aaberg
name: Kaste, Øyvind
Publisher: name: My University
Year: 2020
Subjects: Luftverunreinigung

description: The report presents trends in sulphate, nitrate, chloride, base cations, ANC (acid neutralising capacity), pH and DOC at circa 500 ICP Waters sites in Europe and North America for the period 1990-2016. Time series were analysed for trends in annual median values, annual extreme values and change points, that indicate years with sudden changes in trend or level. Also provided is a brief overview of possible implications of land use change for recovery of acidified surface waters. © Norsk institutt for vannforskning/Norwegian Institute for Water Research