cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HL-Histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
Creators: name: Ernsberger, Paul
name: Kroeze, Wesley K.
name: Steinberg, SeAnna
name: Jayathilake, Karu
name: Popadak, Beth A.
name: Renock, Sean M.
name: Roth, Bryan L.
name: Meltzer, Herbert Y.
name: Hufeisen, Sandra J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: As a result of superior efficacy and overall tolerability, atypical antipsychotic drugs have become the treatment of choice for schizophrenia and related disorders, despite their side effects. Weight gain is a common and potentially serious complication of some antipsychotic drug therapy, and may be accompanied by hyperlipidemia, hypertension and hyperglycemia and, in some extreme cases, diabetic ketoacidosis. The molecular mechanism(s) responsible for antipsychotic drug-induced weight gain are unknown, but have been hypothesized to be because of interactions of antipsychotic drugs with several neurotransmitter receptors, including 5-HT2A and 5-HT2Cserotonin receptors, H1-histamine receptors, α1- and α2-adrenergic receptors, and m3-muscarinic receptors. To determine the receptor(s) likely to be responsible for antipsychotic-drug-induced weight gain, we screened 17 typical and atypical antipsychotic drugs for binding to 12 neurotransmitter receptors. H1-histamine receptor affinities for this group of typical and atypical antipsychotic drugs were significantly correlated with weight gain (Spearman ρ=−0.72; p less than 0.01), as were affinities for α1A adrenergic (ρ=−0.54; p less than 0.05), 5-HT2C (ρ=−0.49; p less than 0.05) and 5-HT6 receptors (ρ=−0.54; p less than 0.05), whereas eight other receptors' affinities were not. A principal components analysis showed that affinities at the H1, α2A, α2B, 5-HT2A, 5-HT2C, and 5-HT6 receptors were most highly correlated with the first principal component, and affinities for the D2, 5-HT1A, and 5-HT7 receptors were most highly correlated with the second principal component. A discriminant functions analysis showed that affinities for the H1 and α1A receptors were most highly correlated with the discriminant function axis. The discriminant function analysis, as well as the affinity for the H1-histamine receptor alone, correctly classified 15 of the 17 drugs into two groups; those that induce weight gain and those that do not. Because centrally acting H1-histamine receptor antagonists are known to induce weight gain with chronic use, and because H1-histamine receptor affinities are positively correlated with weight gain among typical and atypical antipsychotic drugs, it is recommended that the next generation of atypical antipsychotic drugs be screened to avoid H1-histamine receptors.
Aizoon Jacq.
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. Aizoon Jacq. Cat. 155. Bis 3415m: Oberrothorn bei Zermatt (Braun-Blanquet 1919); andere hohe Fundstellen sind: Platthorngrat bei Zermatt, 3100 m (idem 1919); Südhang des Kleinen Allalinhorns bei der Britanniahütte (Saastal), 3030-3050 m (D. Dutoit 1937); Valsorey, 3000 m (Guyot); Gornergrat bei Zermatt, Südhang, gegen 3000 m (Thellung); Eggishorn, 2900 m (J.). Var. Jaccardii Becherer, nomen novum (S. Aizoon var. longifolia H. Jaccard non Gaudin) - 2: Ob Saillon (Gams). - 3: Ob Saxon (F.); Blumatt im Turtmanntal (J.); Zermatt-Findelen (Huber). Var. elongata Engler - 3: Mattmark im Saastal (A. Keller). -4: Rappental (B. C.W.). Var. brevifolia (Sternb.) Engler - l: Sex du Coeur (J.); Emaney (Coquoz). - 2: Muveran (J.); ob Ardon (J.); ob Ayent (P.). - 3: Val d'Entremont (Jaquet, Zahn); Val de Bagnes (Zahn). - 4: Binntal (Binz). Var. Sturmiana (Schott, Nyman et Kotschy) - Oberwallis (Favrat; nach Freyn Lit. 1900, S. 406). Var. hirtifolia (Freyn) Hayek - «Oberes Wallis» (nach Freyn,l. c., S.408).- 3:Almagell im Saastal, 2200 m (Menzi).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
2023 OpenFF Annual Meeting - A neural network for self-consistent charges
Creators: name: Wang, Lily
Publisher: name: Zenodo
Year: 2023

description: A neural network for self-consistent charges Lily Wang Open Force Field This is a presentation from the second day of the 2023 OMSF Symposium in Boston, which ran as a hybrid in-person/virtual event. https://youtu.be/Idfbw8f8Kd8
description: Research supported by NIH R01 GM132386
Investigating the biosynthesis of bioactive compounds in fungi
Creators: name: Hrupins, Vjaceslavs
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2021
Subjects: subject: Polyketide Synthases
subject: Heterologous Expression
subject: ACP
subject: Crosslink of Proteins
subject: Squalestatin S1
subject: Byssochlamic Acid
subject: Zaragozic Acid
subject: Dehydratase
subject: Citrate Synthase
subject: Polyketidsynthasen
subject: heterologe Expression
subject: Verlinkung von Proteinen
subject: Byssochlamsäure
subject: Citrat Synthase
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Fungal Type I polyketide synthases (PKS) are large multifunctional enzymes with a complex structure consisting of multiple functional domains. They produce complex bioactive products such as squalestatin S1 27 and byssochlamic acid 106. The main focus of the projects lies on highly reducing iterative polyketide synthases, especially on their structure and function. Previous work has shown that generating structural information from cross-linked polyketide domains can be the first step towards the elucidation of function and programming. In this thesis we have cloned and heterologously expressed the squalestatin tetraketide synthase (SQTKS) KS/AT didomain, standalone DH domain and the ACP. The SQTKS KS/AT didomain and the ACP were heterologously expressed in E. coli but were obtained as insoluble (KS/AT) or inactive (ACP) proteins. The ACP and the standalone DH domain from the Byssochlamys fulva nonadride PKS (bfPKS) were expressed for the first time. Both proteins were successfully expressed in E. coli and showed catalytic activity as measured by mass spectrometry. The bfPKS ACP was used for crosslinking attempts. Biosynthetic enzymes were expressed and used for the enzymatic conversion of chemically synthesized pantetheine linker analogues into CoA linker analogues. A phosphopantetheine transferase (PPTase, also expressed) was used to load the linkers onto the bfPKS ACP. Cross-linking between bfPKS ACP and DH domains of SQTKS, bfPKS and the Strobilurin tenacellus strobilurin PKS (stPKS) were tried but no linking was observed. In vitro investigations of the B. fulva citrate synthase (bfCS) revealed its substrate preference. The bfCS showed conversion of CoA bound substrate but no conversion for the bfPKS ACP bound one. The SQTKS standalone methyltransferase (C-MeT) domain did not convert the natural substrate which was bound to the bfPKS ACP and was inactive as in previous investigations.
Optimal rates of convergence for sparse covariance matrix estimation
Creators: name: Cai, T. Tony
name: Zhou, Harrison H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: This paper considers estimation of sparse covariance matrices and establishes the optimal rate of convergence under a range of matrix operator norm and Bregman divergence losses. A major focus is on the derivation of a rate sharp minimax lower bound. The problem exhibits new features that are significantly different from those that occur in the conventional nonparametric function estimation problems. Standard techniques fail to yield good results, and new tools are thus needed. We first develop a lower bound technique that is particularly well suited for treating "two-directional" problems such as estimating sparse covariance matrices. The result can be viewed as a generalization of Le Cam's method in one direction and Assouad's Lemma in another. This lower bound technique is of independent interest and can be used for other matrix estimation problems. We then establish a rate sharp minimax lower bound for estimating sparse covariance matrices under the spectral norm by applying the general lower bound technique. A thresholding estimator is shown to attain the optimal rate of convergence under the spectral norm. The results are then extended to the general matrix $\ell_w$ operator norms for $1\le w\le \infty$. In addition, we give a unified result on the minimax rate of convergence for sparse covariance matrix estimation under a class of Bregman divergence losses.
description: Published in at http://dx.doi.org/10.1214/12-AOS998 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Development of CO2 stable (La0.6Ca0.4)(Co0.8Fe0.2)O3-δ hollow fiber membranes for the plasma induced CO2 conversion
Creators: name: Buck, Frederic
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2021
Subjects: subject: Plasma
subject: CO2 conversion
subject: MIEC hollow fiber membranes
subject: Oxygen permeation
subject: CO2 Konversion
subject: MIEC Hohlfasermembran
subject: Sauerstoffpermeation
subject: Dewey Decimal Classification::500 | Naturwissenschaften

description: The present work deals with the perovskite (La0.6Ca0.4)(Co0.8Fe0.2)O3-δ (LCCF) in the form of dense hollow fiber membranes for the oxygen separation from CO2 containing gas mixtures. A potential application is the in situ extraction of oxygen from a CO2 plasma. In such a plasma, the CO2 can be split into CO and oxygen by microwave energy. The goal of this work was the development of LCCF hollow fiber membranes, the optimization of the oxygen transport through these membranes and to confirm the applicability of the extraction of oxygen from a CO2 plasma. Prerequisite for the material and the membrane was a good CO2 stability and a good thermal shock resistance. In a long-term test (>200 h) at 900 °C a good CO2 stability could be verified. To optimize the oxygen permeation flux through the membrane, the bulk diffusion and the surface exchange reactions were affected. To optimize the bulk diffusion, hollow fiber membranes with different wall thicknesses and different sintering temperatures were manufactured. With a wall thickness of 81 µm and a sintering temperature of 1220 °C the highest oxygen permeation flux (6.2 ml min-1 cm-2 at 1000 °C) in a CO2 containing atmosphere could be achieved. The surface exchange reactions were affected by the surface etching method. The goal was to increase the roughness of the surfaces, what could be obtained, by H2SO4 treatment. The best results could be achieved by treating the inner and outer surface with H2SO4 for 180 min. The permeation flux could be increased by 86 % compared to the pristine hollow fiber. Furthermore, both permeation limiting steps were addressed by developing asymmetric hollow fibers with a porous support of LCCF and a thin dense layer of LCCF. A gastight dense layer of 22 µm could be achieved. The oxygen permeation flux compared to a dense hollow fiber membrane (wall thickness 179 µm) could be improved by 68.6 %. Finally, the applicability of the plasma induced CO2 conversion was analysed. The oxygen permeation flux of LCCF hollow fiber membranes in different plasmas (air and CO2) were compared with the permeation in an oven heated system. The permeation in an air plasma was 60.6 % higher at a similar temperature, which is caused by the special plasma atmosphere. In the CO2 plasma, the feasibility of the conversion of CO2 in oxygen and CO could be proven and the generated oxygen can be extracted through the LCCF hollow fiber membranes. At a microwave power of 1 kW an oxygen permeation flux of 4.96 ml min-1 cm-2 in a CO2 plasma could be achieved.
Investigations of the Anisotropic Optical Reflectivity of Binary and Ternary Nb-W Oxides Possessing Block-Type Crystal Structure
Creators: name: Rüscher, Claus H.
name: Zimmermann, M.
name: Götte, M.
Publisher: name: Berlin : De Gruyter
Year: 1993
Subjects: subject: Block-type crystal structure
subject: Niobium oxide
subject: Niobium tungsten oxide
subject: Optical reflectivity
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: We have studied the anisotropic optical properties of binary NbO2.5-δ (0 < δ ≤ 0.083) and ternary Nb18-εW8+εO69 (ε = 0, 1,..., 9) compounds using the polarized regular-reflection method. We observed strong anisotropic behaviour for all reduced phases. The anisotropic effect can be related to the crystallographical structure principle and to the doping of charge carriers by the reduction of oxygen (δ) or substitution of W for Nb (ε) in the binary and ternary oxides, respectively. Our results indicate that the charge carriers are confined to the structural block units. For increasing δ and ε, metal-like properties occur (δ≥ 0.1, ε > 8) in the infinite block direction only.
The Persistent Activity of Jupiter-Family Comets at 3 to 7 AU
Creators: name: Kelley, Michael S.
name: Fernandez, Yanga R.
name: Licandro, Javier
name: Lisse, Carey M.
name: Reach, William T.
name: A'Hearn, Michael F.
name: Bauer, James
name: Campins, Humberto
name: Fitzsimmons, Alan
name: Groussin, Olivier
name: Lamy, Philippe L.
name: Lowry, Stephen C.
name: Meech, Karen J.
name: Pittichova, Jana
name: Snodgrass, Colin
name: Toth, Imre
name: Weaver, Harold A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present an analysis of comet activity based on the Spitzer Space Telescope component of the Survey of the Ensemble Physical Properties of Cometary Nuclei. We show that the survey is well suited to measuring the activity of Jupiter-family comets at 3-7 AU from the Sun. Dust was detected in 33 of 89 targets (37 +/- 6%), and we conclude that 21 comets (24 +/- 5%) have morphologies that suggest ongoing or recent cometary activity. Our dust detections are sensitivity limited, therefore our measured activity rate is necessarily a lower limit. All comets with small perihelion distances (q < 1.8 AU) are inactive in our survey, and the active comets in our sample are strongly biased to post-perihelion epochs. We introduce the quantity epsilon-f-rho, intended to be a thermal emission counterpart to the often reported A-f-rho, and find that the comets with large perihelion distances likely have greater dust production rates than other comets in our survey at 3-7 AU from the Sun, indicating a bias in the discovered Jupiter-family comet population. By examining the orbital history of our survey sample, we suggest that comets perturbed to smaller perihelion distances in the past 150 yr are more likely to be active, but more study on this effect is needed.
description: Accepted for publication in Icarus; 40 pages, 13 figures, 7 tables
title: Von der Entdeckung in die Ausstellung. Nassfundkonservierung für die Große Landesausstellung „Pfahlbauten“
Creators: name: Stelzner, Ingrid
name: Betz, Saskia
name: Bott, Kati
Publisher: name: University Library Heidelberg
Year: 2016

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 45, Nr. 1 (2016), Beginn und Erscheinungsfrequenz: Ausgaben pro Band: 4
Dissipation flow-frames: particle, energy, thermometer
Creators: name: Ván, P.
name: Biró, T. S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We associate the following physical co-mover conditions of to different frame choices: i) Eckart: particle flow, ii) Landau-Lifshitz: energy flow, iii) Jüttner: moving thermometer frame. The role of fixing a flow-frame is analysed with respect to local equilibrium concentrating on dissipative currents and forces in single component relativistic fluids. The special role of a "Jüttner frame" is explored and contrasted to the more common Eckart and Landau-Lifshitz choices.
description: JETC'13 conference paper, 6 pages
title: Jungsteinzeitliche Maske aus Bad Schussenried „Riedschachen“ am südlichen Federsee. Ein sensationeller Fund
Creators: name: Schlichtherle, Helmut
Publisher: name: University Library Heidelberg
Year: 2016

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 45, Nr. 1 (2016), Beginn und Erscheinungsfrequenz: Ausgaben pro Band: 4
title: Ausstellung
Creators: name: Redaktion, Die
Publisher: name: University Library Heidelberg
Year: 2016

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 45, Nr. 1 (2016), Beginn und Erscheinungsfrequenz: Ausgaben pro Band: 4
Realisierung neuer Laserkühlverfahren und Spektroskopielaser für einen optischen Magnesium-Frequenzstandard
Creators: name: Rehbein, Nils
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität Hannover
Year: 2006
Subjects: subject: Laserkühlung
subject: Laserstabilisierung
subject: optischer Frequenzstandard
subject: Zwei-Photonen-Kühlen
subject: Quenchkühlen
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: [no abstract]
The High Time Resolution Universe Pulsar Survey VIII: The Galactic millisecond pulsar population
Creators: name: Levin, L.
name: Bailes, M.
name: Barsdell, B. R.
name: Bates, S. D.
name: Bhat, N. D. R.
name: Burgay, M.
name: Burke-Spolaor, S.
name: Champion, D. J.
name: Coster, P.
name: D'Amico, N.
name: Jameson, A.
name: Johnston, S.
name: Keith, M. J.
name: Kramer, M.
name: Milia, S.
name: Ng, C.
name: Possenti, A.
name: Stappers, B.
name: Thornton, D.
name: van Straten, W.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We have used millisecond pulsars (MSPs) from the southern High Time Resolution Universe (HTRU) intermediate latitude survey area to simulate the distribution and total population of MSPs in the Galaxy. Our model makes use of the scale factor method, which estimates the ratio of the total number of MSPs in the Galaxy to the known sample. Using our best fit value for the z-height, z=500 pc, we find an underlying population of MSPs of 8.3(\pm 4.2)*10^4 sources down to a limiting luminosity of L_min=0.1 mJy kpc^2 and a luminosity distribution with a steep slope of d\log N/d\log L = -1.45(\pm 0.14). However, at the low end of the luminosity distribution, the uncertainties introduced by small number statistics are large. By omitting very low luminosity pulsars, we find a Galactic population above L_min=0.2 mJy kpc^2 of only 3.0(\pm 0.7)*10^4 MSPs. We have also simulated pulsars with periods shorter than any known MSP, and estimate the maximum number of sub-MSPs in the Galaxy to be 7.8(\pm 5.0)*10^4 pulsars at L=0.1 mJy kpc^2. In addition, we estimate that the high and low latitude parts of the southern HTRU survey will detect 68 and 42 MSPs respectively, including 78 new discoveries. Pulsar luminosity, and hence flux density, is an important input parameter in the model. Some of the published flux densities for the pulsars in our sample do not agree with the observed flux densities from our data set, and we have instead calculated average luminosities from archival data from the Parkes Telescope. We found many luminosities to be very different than their catalogue values, leading to very different population estimates. Large variations in flux density highlight the importance of including scintillation effects in MSP population studies.
description: 13 pages, 5 figures, 5 tables. Accepted for publication in MNRAS
Prevalence of peanut and tree nut allergy in the US determined by a random digit dial telephone survey
Creators: name: Sampson, Hugh A.
name: Munoz-Furlong, Anne
name: Burks, A. Wesley
name: Sicherer, Scott H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Background: Allergy to peanuts and tree nuts (TNs) is one of the leading causes of fatal and near-fatal food-induced allergic reactions. These allergies can be lifelong and appear to be increasing in prevalence. Despite the seriousness of these allergies, the prevalence of peanut and TN allergy in the general population is unknown. Objective: We sought to determine the prevalence of peanut and TN allergy among the general population of the United States. Methods: We used a nationwide, cross-sectional, random digit dial telephone survey with a standardized questionnaire. Results: A total of 4374 households contacted by telephone participated (participation rate, 67%), representing 12,032 individuals. Peanut or TN allergy was self-reported in 164 individuals (1.4%; 95% confidence interval [CI], 1.2%-1.6%) in 151 households (3.5%; 95% CI, 2.9%-4.0%). The prevalence of reported allergy in adults (1.6%) was higher than that found in children under 18 years of age (0.6%). In 131 individuals, details of the reactions were obtained. When applying criteria requiring reactions to be typical of IgE-mediated reactions (hives, angioedema, wheezing, throat tightness, vomiting, and diarrhea) within an hour of ingestion, 10% of these subjects were excluded. Among the remaining 118 subjects, allergic reactions involved 1 organ system (skin, respiratory, or gastrointestinal systems) in 50 subjects, 2 in 45 subjects, and all 3 in 23 subjects. Forty-five percent of these 118 respondents reported more than 5 lifetime reactions. Only 53% of these 118 subjects ever saw a physician for the allergic reaction, and only 7% had self-injectable epinephrine available at the time of the interview. The prevalence of peanut and TN allergy was adjusted by assuming that 10% of the remaining 33 subjects without a description of their reactions would also be excluded and correcting for a 7% false-positive rate for the survey instrument. A final “corrected” prevalence estimate of 1.1% (95% CI, 1.0%-1.4%) was obtained. Conclusions: Peanut and/or TN allergy affects approximately 1.1% of the general population, or about 3 million Americans, representing a significant health concern. Despite the severity of reactions, about half of the subjects never sought an evaluation by a physician, and only a few had epinephrine available for emergency use.
Top Five Issues Facing North Carolina Planners in the Future
Creators: name: Boswell, Denise
name: Bullock, Shanelle
name: Leight, Kimberly S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: As we look back to celebrate the most influential planners of the past 50 years, it is also important to look ahead to the issues, challenges, and dilemmas that will face North Carolina’s next generation of planners over the coming 50 years. In this vein, members of the North Carolina chapter of the American Planning Association submitted their nominations for these emerging issues in 11 broad categories, including environment/sustainability, coastal issues, transportation, quality of life/ sense of place, open space/agricultural land protection, economic development, affordable housing, population growth/age/diversity, hazard mitigation, sprawl/redevelopment, and others. After receiving dozens of entries, the three authors condensed the impressive number of nominations into the Top Five Emerging Issues listed below.
Regulation der Phosphorylierung des NF-kB reprimierenden Faktors (NRF)
Creators: name: Rother, Sascha
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität Hannover
Year: 2008
Subjects: subject: NRF
subject: NF-kB
subject: Proteinphosphorylierung
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: [no abstract]
The cancer genome atlas pan-cancer analysis project
Creators: name: Mills, Gordon B.
name: Mills Shaw, Kenna R.
name: Shmulevich, Ilya
name: Stuart, Joshua M.
name: Ellrott, Kyle
name: Sander, Chris
name: The Cancer Genome Atlas Research Network
name: Collisson, Eric A.
name: Ozenberger, Brad A.
name: Weinstein, John N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.
Tensor-network approach for quantum metrology in many-body quantum systems
Creators: name: Chabuda, Krzysztof
name: Dziarmaga, Jacek
name: Osborne, Tobias J.
name: Demkowicz-Dobrzański, Rafał
Publisher: name: London : Nature Publishing Group
Year: 2020
Subjects: subject: identification method
subject: magnetic field
subject: network analysis
subject: numerical method
subject: quantum mechanics
subject: article
subject: human
subject: noise
subject: phase transition
subject: Dewey Decimal Classification::500 | Naturwissenschaften

description: Identification of the optimal quantum metrological protocols in realistic many particle quantum models is in general a challenge that cannot be efficiently addressed by the state-of-the-art numerical and analytical methods. Here we provide a comprehensive framework exploiting matrix product operators (MPO) type tensor networks for quantum metrological problems. The maximal achievable estimation precision as well as the optimal probe states in previously inaccessible regimes can be identified including models with short-range noise correlations. Moreover, the application of infinite MPO (iMPO) techniques allows for a direct and efficient determination of the asymptotic precision in the limit of infinite particle numbers. We illustrate the potential of our framework in terms of an atomic clock stabilization (temporal noise correlation) example as well as magnetic field sensing (spatial noise correlations). As a byproduct, the developed methods may be used to calculate the fidelity susceptibility—a parameter widely used to study phase transitions. © 2020, The Author(s).
Building Rural Officials' Capacity: Circuit Riders and Technical Assistance
Creators: name: Coe, Benjamin P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1983

description: Recognition is growing in the literature of the last decade that rural local government is being left behind and sorely needs help. City government has full-time employees and has usually been able to evolve to match the growing complexity of both society and the political system. On the other hand, rural local officials are mostly part-time people with other full-time jobs. Their pay is usually in the lower four figures for twenty hours a week or more of effort. It's no wonder then that small communities are found to lack the ability to anticipate potential problems and take preventive action. They are often crisis oriented because their elected officials can just barely keep up, let alone look ahead. And when they do foresee problems they often do not know where to turn for needed information and consulting help.
title: Archäologische Informationen, Vol 6, No 1 (1983): Archäologische Informationen
Creators: name: DGUF E.V.
Publisher: name: University Library Heidelberg
Year: 2016

description: Seriation
description: Seriation
description: Titel
 Vorwort...4-5
 Inhalt...6-7
 Korrespondenzanalyse und Seriation...8-21
 Bericht über die Tagung am 5. April 1983 in Ratzeburg: Arbeitsgemeinschaft Quantitative Methoden in der Archäologie...51-52
 Zur Interpretation der Rohmaterial- und Grundformspektren bandkeramischer Silexinventare auf der Aldenhovener Platte unter besonderer Berücksichtigung des Siedlungsplatzes Lamersdorf 2...53-55
 Nicht-alternative Merkmalzustände: Beispiele zu Fragellungen und Auswertungen...57-58
 Laien in der Urgeschichtsforschung: Kooperation - Integration?...70-72
 Beziehungen der frühen Salier Konrad II. und Heinrich III. zu den Staatengründungen der Wikinger und Normannen in Nordeuropa und Süditalien...83
 Mesolithikum im Rheinland...84-88
 Nachrichten...89
 Ausgräber anderer Art. Das Bild der Archäologie in Presse und Funk...77-78
Cotyledon L.
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. Cotyledon L. Cat. 155. Vgl. Mariétan Lit. 1936, S. 105-106; 1941, S. 103-104. l: Unter La Preisa (Coquoz). - 2: Ob Naters im Massatal, rechte Talseite, zwischen 1300 und 2400 m ziemlich verbreitet (Mariétan). - 3: Nach Stephan Biner (handschriftliches Verzeichnis der Flora von Zermatt, 1862) eine Fundstelle bei Zermatt: «Kelle» nördlich des Gornergrates; zu be- stätigen. - 3a: Umgebung von Simplon-Dorf (Becherer, Thommen); Alpien (Becherer und Thommen). - 4: Linke Seite des Massatales (Mariétan Lit. 1941, S. 104). Var. citrina Farquet - l: La Tenda ob Salvan (F.).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Confucian and Taoist intervention effects on Self-construal and Thinking Mode - Data and Results
Creators: name: Wang, Zhen-Dong
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Education
subject: Multicultural Psychology
subject: Social and Behavioral Sciences

description: The raw data (after coding) and process data generated by the study “Confucian and Taoist intervention effects on Self-construal and Thinking Mode”, as well as all results obtained from the data analysis.
High energy emission from transients
Creators: name: Hinton, J. A.
name: Starling, R. L. C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Cosmic explosions dissipate energy into their surroundings on a very wide range of time-scales: producing shock waves and associated particle acceleration. The historical culprits for the acceleration of the bulk of Galactic cosmic rays are supernova remnants: explosions on ~10000 year time-scales. Increasingly however, time-variable emission points to rapid and efficient particle acceleration in a range of different astrophysical systems. Gamma-ray bursts have the shortest time-scales, with inferred bulk Lorentz factors of ~1000 and photons emitted beyond 100 GeV, but active galaxies, pulsar wind nebulae and colliding stellar winds are all now associated with time-variable emission at ~TeV energies. Cosmic photons and neutrinos at these energies offer a powerful probe of the underlying physical mechanisms of cosmic explosions, and a tool for exploring fundamental physics with these systems. Here we discuss the motivations for high-energy observations of transients, the current experimental situation, and the prospects for the next decade, with particular reference to the major next-generation high-energy observatory CTA.
description: 10 pages, 4 figures. Accepted to Philosophical Transactions A of the Royal Society. Based on a review talk presented at the Royal Society meeting 'New windows on transients across the Universe', 23-24 April 2012
Vorkurs in Zeiten von Corona – Zur Leistungsentwicklung in Distanz und Präsenz
Creators: name: Kirsten, Katharina
name: Greefrath, Gilbert
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Vorkurs
subject: Distanzlernen
subject: Mathematikleistung
subject: Innovative Lernumgebungen
subject: interdisziplinär
subject: Schnittstelle Sek 2 und Hochschule
subject: 510

description: Vorkurse stellen an vielen Hochschulen ein etabliertes Unterstützungsangebot dar, um mathematische Vorkenntnisse zu Studienbeginn zu vertiefen. Schon seit einigen Jahren werden dabei verschiedene Vorkursformate realisiert: Neben der klassischen Präsenzveranstaltung bieten verschiedene Hochschulen Blended-Learning- oder reine E-Learning-Kurse an (Derr et al., 2021; Fischer, 2014; Greefrath et al., 2017). Durch die pandemiebedingte Umstellung der Lehre wurde eine erneute Erweiterung der Lehrformate notwendig. Im Unterschied zu tradierten E Learning-Angeboten orientieren sich pandemiebedingte Distanzformate häufig stärker an der Präsenzlehre und beinhalten vermehrt synchrone Elemente (Büchele et al., 2021). Inwieweit dieses Format, auch im Vergleich, geeignet ist, die veranstaltungsbezogenen Ziele zu erreichen, wird in der vorgestellten Studie untersucht.
Primordial black hole constraints for curvaton models with predicted large non-Gaussianity
Creators: name: Bugaev, E. V.
name: Klimai, P. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the early Universe scenario which allows for production of non-Gaussian curvature perturbations at small scales. We study the peculiarities of a formation of primordial black holes (PBHs) connected with the non-Gaussianity. In particular, we show that PBH constraints on the values of curvature perturbation power spectrum amplitude are strongly dependent on the shape of perturbations and can significantly (by two orders of magnitude) deviate from the usual Gaussian limit ${\cal P}_ζ\lesssim 10^{-2}$. We give examples of PBH mass spectra calculations and PBH constraints for the particular case of the curvaton model.
description: The manuscript has some intersections with arxiv:1210.3262 but contains new ingredients and more precise conclusions; title is changed appropriately. Includes 13 pages, 4 figures. Accepted for publication in Int. J. Mod. Phys. D
Mehrkernige Komplexverbindungen mit sequentiellen und konzertierten Schalteffekten
Creators: name: Wolff, Morris
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2020
Subjects: subject: Spin-Übergang
subject: Hybridfunktionale
subject: Eisenkomplexe
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: In dieser Arbeit wird das Verhalten magnetisch schaltbarer mehrkerniger Metall-Komplexe theoretisch erforscht. Es wird gezeigt, unter welchen Bedingungen die Komplexe einen Spin Crossover zeigen. Dieser kann durch Mössbauer-Messungen und durch Berechnungen mit geeigneten Hybrid-Funktionalen und sehr großen All-Elektronen-Basis-Sätzen charakterisiert werden. Der Spin Crossover entspricht einem magnetischen Schaltvorgang. Die in dieser Arbeit untersuchten Komplexe sind durch Temperaturerhöhung sequentiell schaltbar. Diese Komplexe liegen bei tiefen Temperaturen (20 K) im Low Spin-Zustand (LS) vor. Beim Erwärmen von 20 K auf 300 K gehen alle Spin Crossover-Zentren nacheinander vom LS-Zustand in den High Spin-Zustand (HS) über. Die in dieser Arbeit untersuchten Komplexe können bei tiefen Temperaturen durch Bestrahlung mit Laser-Licht (25 mW/cm2 514.5 nm, grün, Argon-Ionen-Laser) auch konzertierte Spin Crossover-Prozesse (SCO) durchführen. In diesem Prozess gehen alle Spin Crossover-Zentren gleichzeitig vom LS-Zustand in den HS-Zustand über. Durch theoretische Berechnungen mit den Hybrid-Funktionalen B3LYP und OPBE wird demonstriert, wie der HS-Zustand eines SCO-Zentrums relativ zum LS-Zustand stabilisiert, wenn das Fe(II) im Stark-Feld zu ein Fe(III) oxidiert wird. Außerdem wird beobachtet, dass für Komplexe mit starren Liganden, in denen die Spin-Dichte in allen drei Spin-Zuständen Low Spin (LS), High Spin (HS) und intermediate Spin (ES) am Metallatom lokalisiert bleibt, OPBE die besseren Resultate ergibt als B3LYP. Im Gegensatz dazu liefert B3LYP bei Komplexen bei Komplexen mit nichtstarren, unter Spannung stehenden und deformierbaren Liganden, in denen die Spin-Dichte in der Reihenfolge LS < ES << HS zunehmend auf die Donor-Atome des Liganden übertragen wird, B3YLP die besseren Resultate.
Rural Music Education in China: Perceptions of Music Educators in Henan Province
Creators: name: Zhang, Zhilin
Publisher: name: My University
Year: 2023
Subjects: subject: Chinese music education, rural music education, general music education, elementary education, students’ experiences, “left-behind” children
subject: Music and Dance
subject: Theatre and Drama
subject: Arts

description: This study investigated the perception and experiences of rural music educators in Henan Province, China. Through the lenses of rural music teachers, the study focused on the values of general music education and revealed students’ music learning experiences in rural schools. The main research question was: What are the participants’ experiences of teaching general music education in rural schools in Ren County (a pseudonym), Henan Province? There were two guiding questions: a) What is the value and role of music education in rural schools and communities? b) How do participants describe students and their music learning experiences? To this end, I surveyed and interviewed three rural music teachers and one music director in Ren County. A qualitative design was used to gather the teachers’ insights regarding their own experiences and those of their students, and their music programs. Data collection included one survey and two 90-minute interviews with each teacher. Interviews were transcribed, translated from Mandarin to English, coded by category, and analyzed for themes. Findings suggested that with the current emphasis on aesthetic education, rural music education is increasingly important both in national policy and at the county level, but it continues to be in a vulnerable position within the school community due to the unchanged test-oriented education system in China. All participants believe that music education has rich benefits for rural students, and especially for rural “left-behind” children. This research reflected the deeply rooted challenges in rural music education in Ren County while also presented positive trends for future development.
Some Problems on the Classical N-Body Problem
Creators: name: Albouy, Alain
name: Cabral, Hildeberto E.
name: Santos, Alan A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 70F10 70F15

description: Our idea is to imitate Smale's list of problems, in a restricted domain of mathematical aspects of Celestial Mechanics. All the problems are on the n-body problem, some with different homogeneity of the potential, addressing many aspects such as central configurations, stability of relative equilibrium, singularities, integral manifolds, etc. Following Steve Smale in his list, the criteria for our selection are: (1) Simple statement. Also preferably mathematically precise, and best even with a yes or no answer. (2) Personal acquaintance with the problem, having found it not easy. (3) A belief that the question, its solution, partial results or even attempts at its solution are likely to have great importance for the development of the mathematical aspects of Celestial Mechanics.
description: 10 pages, list of mathematical problems
Targeted Economic Development: Its Role in Maine Economic Policy
Creators: name: Dickstein, Carla
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Editors' Note: Although this article is about targeted economic development in Maine, we feel that its findings are pertinent to conditions here in North Carolina, especially considering the present reality of welfare reform. In the previous article, we considered various approaches to helping people move from public assistance, unemployment, and underemployment to decent jobs. Targeted economic development is another strategy that planners and community and economic developers in North Carolina and other Southeastern states may want to add to their toolbox of job development strategies to help people make these transitions.
Elliptic Euler-Poisson-Darboux equation, critical points and integrable systems
Creators: name: Konopelchenko, B. G.
name: Ortenzi, G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: Structure and properties of families of critical points for classes of functions $W(z,\bar{z})$ obeying the elliptic Euler-Poisson-Darboux equation $E(1/2,1/2)$ are studied. General variational and differential equations governing the dependence of critical points in variational (deformation) parameters are found. Explicit examples of the corresponding integrable quasi-linear differential systems and hierarchies are presented There are the extended dispersionless Toda/nonlinear Schrödinger hierarchies, the "inverse" hierarchy and equations associated with the real-analytic Eisenstein series $E(β,\bar{β};1/2)$among them. Specific bi-Hamiltonian structure of these equations is also discussed.
description: 18 pages, no figures
Metabolic Pathway of Natural Antioxidants, Antioxidant Enzymes and ROS Providence
Creators: name: Huchzermeyer, Bernhard
name: Menghani, Ekta
name: Khardia, Pooja
name: Shilu, Ayushi
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: antioxidants
subject: futile sequences
subject: oxidative burst
subject: ROS
subject: ROS defense
subject: ROS signaling
subject: stress response
subject: stress tolerance
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Based on the origin, we can classify different types of stress. Environmental factors, such as high light intensity, adverse temperature, drought, or soil salinity, are summarized as abiotic stresses and discriminated from biotic stresses that are exerted by pathogens and herbivores, for instance. It was an unexpected observation that overproduction of reactive oxygen species (ROS) is a common response to all kinds of stress investigated so far. With respect to applied aspects in agriculture and crop breeding, this observation allows using ROS production as a measure to rank the stress perception of individual plants. ROS are important messengers in cell signaling, but exceeding a concentration threshold causes damage. This requires fine‐tuning of ROS production and degradation rates. In general, there are two options to control cellular ROS levels, (I) ROS scavenging at the expense of antioxidant consumption and (II) enzyme‐controlled degradation of ROS. As antioxidants are limited in quantity, the first strategy only allows temporarily buffering of a certain cellular ROS level. This way, it prevents spells of eventually damaging ROS concentrations. In this review, we focus on the second strategy. We discuss how enzyme‐controlled degradation of ROS integrates into plant metabolism. Enzyme activities can be continuously operative. Cellular homeostasis can be achieved by regulation of respective gene expression and subsequent regulation of the enzyme activities. A better understanding of this interplay allows for identifying traits for stress tolerance breeding of crops. As a side effect, the result also may be used to identify cultivation methods modifying crop metabolism, thus resulting in special crop quality. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
2023 OpenFF Annual Meeting - Espaloma and the opportunities afforded by moving to a machine learning framework for SMIRNOFF and Graph Net optimization
Creators: name: Chodera, John
Publisher: name: Zenodo
Year: 2023

description: Espaloma and the opportunities afforded by moving to a machine learning framework for SMIRNOFF and Graph Net optimization John D. Chodera MSKCC Computational and Systems Biology Program http://choderalab.org This is a presentation from the second day of the 2023 OMSF Symposium in Boston, which ran as a hybrid in-person/virtual event. https://youtu.be/yUw2YsrI860
description: Research supported by NIH R01 GM132386
Binary gamma-ray pulsars
Creators: name: Nieder, Lars
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2021
Subjects: subject: neutron stars
subject: gamma rays
subject: binary pulsars
subject: search methods
subject: Neutronensterne
subject: Gamma-Strahlen
subject: Binär-Pulsare
subject: Suchmethoden
subject: Dewey Decimal Classification::500 | Naturwissenschaften
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
subject: Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie

description: The first pulsar has been detected in 1967 as a seemingly pulsating radio source. Since then, more than 2800 pulsars have been discovered. Most of them also in radio. With the launch of the Fermi Gamma-ray Space Telescope in 2008, more than 250 gamma-ray pulsars have been detected. This thesis concerns the development of methods to directly search the gamma-ray data for pulsars in binary systems, and presents the discovery and analysis of four such pulsars.
description: 1967 wurde der erste Pulsar als scheinbar pulsierende Radioquelle entdeckt. Seitdem wurden mehr als 2800 weitere Pulsare gefunden, die meisten davon ebenfalls im Radiobereich. Mit dem Start des Fermi Gamma-ray Space Telescope im Jahr 2008 wurden mittlerweile mehr als 250 Gamma-Pulsare entdeckt. Diese Arbeit behandelt die Entwicklung von Suchmethoden, um Gamma-Daten direkt nach Pulsaren in Binärsystemen zu durchsuchen, und präsentiert die Entdeckung und Vermessung von vier solchen Pulsaren.
Nonlocality and fluctuations near the optical analog of a sonic horizon
Creators: name: Bar-Ad, S.
name: Schilling, R.
name: Fleurov, V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We consider the behavior of fluctuations near the sonic horizon and the role of the nonlocality of interaction (nonlinearity) on their regularization. The nonlocality dominates if its characteristic length scale is larger than the regularization length. The influence of nonlocality may be important in the current experiments on the transonic flow in Kerr nonlinear media. Experimental conditions, under which the observation of straddled fluctuations can be observed, are discussed.
description: 1 figure