cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of The Antarctic sea ice alga Chlamydomonas sp. ICE-L provides insights into adaptive patterns of chloroplast evolution
Creators: name: Zhang, Zhenhua
name: An, Meiling
name: Miao, Jinlai
name: Gu, Zhiqiang
name: Liu, Chang
name: Zhong, Bojian
Publisher: name: figshare
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Table S1. Results of the basic (M0) model test of individual genes and the concatenated data. Table S2. Results of the correct P-value of LRT in branch-model test. Table S3. Results of site-model test to each gene-specific and the concatenated data. Table S4. Results of branch-site model analyses using the concatenated data. Table S5. Results of convergence test between Chlamydomonas sp. ICE-L and Dunaliella salina. Figure S1. Results of divergence time analyses. The estimated divergence times were showed with 95% confidence intervals. Figure S2. The dN/dS estimates for the concatenated data using the M8 random-site model. The y-axis shows the BEB posterior mean estimate of dN/dS for each site. (DOCX 341 kb)
Emissioni marittime di CO2 nello Spazio Economico Europeo
Creators: name: Mannarini, Gianandrea
name: Salinas, Mario Leonardo
Publisher: name: Zenodo
Year: 2022

description: In conformità al Regolamento UE 757/2015, tutte le navi con stazza lorda superiore a cinquemila tonnellate e porti di scalo nello Spazio Economico Europeo (SEE) devono monitorare, comunicare e verificare (“monitoring, reporting, and verification” - MRV) le proprie emissioni di anidride carbonica. I dati sono pubblicati con aggregazione annuale dall’Agenzia Europea per la Sicurezza Marittima mediante il sistema THETIS-MRV.

In questo lavoro sono stati utilizzati dati MRV dei primi quattro anni (2018-2021) per tutte la flotta SEE (circa 12mila navi). E’ stato quantificato l’uso dei vari sistemi di monitoraggio delle emissioni consentiti dalla normativa MRV, trovando che le misure dirette di CO2 sono ancora pressocche' inutilizzate. Inoltre sono stati valutati la riduzione ed il rimbalzo nel livello di emissioni negli anni 2020 e 2021. Mediante un test non parametrico, sono state evidenziate: riduzioni statisticamente significative per quasi tutte le categorie di navi tra il 2019 ed il 2020; rimbalzi robusti tra il 2020 ed il 2021 per navi che portano passeggeri;  ulteriori riduzioni per petroliere e navi che portano gas liquefatto e prodotti chimici. Tale risultato richiede ulteriori investigazioni in congiunzione con altri tipi di dati.Il sistema THETIS-MRV offre una promettente base di dati per comprendere l’andamento delle emissioni di CO2 dell’industria marittima in Europa.
description: This work was supported by the European Regional Development Fund through the Italy-Croatia Interreg programme, project GUTTA, grant number 10043587.
Xenorhabdus stockiae KT835471-mediated feasible biosynthesis of metal nanoparticles for their antibacterial and cytotoxic activities
Creators: name: Gobinath Chandrakasan
name: PrabuKumar Seetharaman
name: Sathishkumar Gnanasekar
name: Kadarkarai, Murugan
name: Sivaramakrishnan Sivaperumal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: In this study, extracellular metabolites of symbiotic bacteria Xenorhabdus stockiae (KT835471) was employed for the synthesis of silver (XsAgNPs) and gold nanoparticles (XsAuNPs). Synthesized NPs were characterized using high throughput instrumentation which confirms the generation of stable, crystalline XsAgNPs and XsAuNPs with the mean size of 14 ± 6 and 14 ± 5, respectively. Further, the NPs exhibits an excellent bactericidal effect against six different pathogens. On the other hand, NPs displayed an outstanding anticancer activity against human lung adenocarcinoma epithelial cells (A549). Therefore, the present study strongly suggests that metal NPs encrusted with functional bio-moieties can be used for different biomedical applications.
Additional file 12: of Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Creators: name: Cornuault, Jeffrey
name: Petit, Marie-AgnĂ¨s
name: Mariadassou, Mahendra
name: Benevides, Leandro
name: Moncaut, Elisabeth
name: Langella, Philippe
name: Sokol, Harry
name: De Paepe, Marianne
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Sequences of oligonucleotides used for quantitative PCR. (DOCX 15Â kb)
Additional file 1: of Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Creators: name: Cornuault, Jeffrey
name: Petit, Marie-AgnĂ¨s
name: Mariadassou, Mahendra
name: Benevides, Leandro
name: Moncaut, Elisabeth
name: Langella, Philippe
name: Sokol, Harry
name: De Paepe, Marianne
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Accession numbers of the bacterial and type phage genomes and bacterial coordinates of all prophages. (DOCX 22Â kb)
Additional file 2: of Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Creators: name: Cornuault, Jeffrey
name: Petit, Marie-AgnĂ¨s
name: Mariadassou, Mahendra
name: Benevides, Leandro
name: Moncaut, Elisabeth
name: Langella, Philippe
name: Sokol, Harry
name: De Paepe, Marianne
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Similarity matrices of phage proteins within each proposed genus. For each pair of phages, the percentage of shared proteins as well as their mean amino acid identity is indicated. For each proposed genus, the closest known phage was included in the analysis, and its host is indicated. Numbers in brackets indicate the number of ORF per genome, and most of the variability within a group is due to annotation errors. Numbers in bold indicate highly homologous prophages, which were considered to correspond to the same species. (DOCX 28Â kb)
Additional file 2: of Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report
Creators: name: Chen, Zihang
name: Gao, Limin
name: Wang, Mi
name: Tang, Yuan
name: Zhao, Sha
name: Liu, Weiping
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: STAT5B variant investigation by Sanger Sequencing. This file provides the method of STAT5B variant investigation by Sanger Sequencing in details. (DOCX 13 kb)
Performance Metrics for Communication Systems with Forward Error Correction
Creators: name: Schmalen, Laurent
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We revisit performance metrics for optical communication systems with FEC. We illustrate the concept of universality and discuss the most widespread performance thresholds. Finally, we show by example how to include FEC into transmission experiments.
description: published at European Conference on Optical Communications (ECOC) 2018
Investigation of large-scale epileptic networks in rodent models of focal epilepsy
Creators: name: Quairiaux, Charles
Publisher: name: Université de Genève
Year: 2020
Subjects: info:eu-repo/classification/ddc/616.8
Epilepsy
Focal epilepsy
Large-scale network
EEG
LFP
Kainate

description: This Privat Docent thesis presents three of my recent studies that explore the development and the mechanisms of large-scale epileptic networks in the kainate mouse model of TLE using high density EEG combined to multiple intracerebral recordings. We reveal that a large-scale epileptic network develops and invade both hemispheres, generating epileptic patterns and altering functional connectivity at the whole brain level. We further show that low frequency synchronization and cross frequency coupling are key mechanisms at works in these large-scale pathologic networks. To introduce these works, I first discuss the fundamental, clinical and translational scientific contributions summarizing current knowledge and providing new insight on the large-scale aspects of focal epilepsies, with a particular focus on mesial temporal lobe epilepsies.
Additional file 4: of Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report
Creators: name: Chen, Zihang
name: Gao, Limin
name: Wang, Mi
name: Tang, Yuan
name: Zhao, Sha
name: Liu, Weiping
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Table S1. Summary of pediatric EBV + PTCL cases. This table shows the clinical features and outcomes of the published pediatric EBV + PTCL cases. (DOCX 14 kb)
Fractional Modelling and Optimal Control of COVID-19 Transmission in Portugal
Creators: name: Rosa, Silverio
name: Torres, Delfim F. M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Mathematics
subject: FOS: Biological sciences
subject: 26A33, 34A08, 49N90, 92C60

description: A fractional-order compartmental model was recently used to describe real data of the first wave of the COVID-19 pandemic in Portugal [Chaos Solitons Fractals 144 (2021), Art. 110652]. Here, we modify that model in order to correct time dimensions and use it to investigate the third wave of COVID-19 that occurred in Portugal from December 2020 to February 2021, and that has surpassed all previous waves, both in number and consequences. A new fractional optimal control problem is then formulated and solved, with vaccination and preventive measures as controls. A cost-effectiveness analysis is carried out, and the obtained results are discussed.
description: This is a preprint of a paper whose final and definite form is published Open Access in 'Axioms' at [https://doi.org/10.3390/axioms11040170]
Additional file 7: of Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Creators: name: Cornuault, Jeffrey
name: Petit, Marie-Agnès
name: Mariadassou, Mahendra
name: Benevides, Leandro
name: Moncaut, Elisabeth
name: Langella, Philippe
name: Sokol, Harry
name: De Paepe, Marianne
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Lagaffe and Mushu virion concentrations in culture supernatants. Quantification of Mushu and Lagaffe virions in different conditions. Numbers represent means of genomes/ml ± s.e.m. of two to five independent experiments. Absorbance of the culture (O.D600nm) reflects the toxicity of the compound on bacterial growth. (DOCX 13 kb)
The value of cohort studies in cardiovascular medicine
Creators: name: Carballo, David Andrés
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616

description: Cardiovascular disease (CVD) has become the leading cause of mortality in high income countries. The leading modifiable risk factors for this remains tobacco smoking, high blood pressure, diabetes mellitus, dyslipidemia as well as air pollution. CVD has therefore come to constitute a major global medical, social and public health challenge and burden to societies at large. Responding to the CVD challenge to stem this epidemic has come to rely on a growing body of evidence generated through a range of epidemiological methods. As the need and demand for more data to drive intensified policies and action increase, it is important to understand what methods and tools are currently available, and what they bring to the field of CVD disease management and epidemiology. In this regard, the demonstrated complementarity of randomized controlled trials and observational studies has proved invaluable and here we review the contribution of cohort studies.
Additional file 5: of Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report
Creators: name: Chen, Zihang
name: Gao, Limin
name: Wang, Mi
name: Tang, Yuan
name: Zhao, Sha
name: Liu, Weiping
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S2. The clinicopathological difference in ENKTL, STLC and our case. This table shows 2 main kinds diseases which should be considered as differential diagnosis and summarizes the key points in differentiation. (DOCX 15 kb)
Living donor nephrectomy: the shift towards minimally invasive surgery in a small volume center
Creators: name: Renard, Julien
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/617

description: Living donor nephrectomy represents a challenging surgery. It must maximize safety and decrease morbidity for the healthy donor. With these goals living donation gradually shifted over the last decade from open to minimally invasive surgery. Compared to open surgery, laparoscopy added less post-operative pain, short hospital stay, lower incisional morbidity, quicker recovery and improved cosmesis, increasing the patient acceptance However, the relatively slow and incomplete technical shift observed is most probably related to the complexity of minimally invasive surgery making it a challenge for medium to low volume centers. In this context, the aim of our research is to analyse the progressive shift from open to minimally-invasive living DN in a center performing this procedure on a monthly basis. For this purpose we conducted an observational retrospective analysis of 169 consecutive living donor Results of our study shows that the evolution from open to minimally invasive DN can be achieved even in a low-volume center with an acceptable surgical safety and efficiency profile. Indeed, the results of RLDN and RLN were comparable to those of larger centers
Elastic properties of Yukawa crystals
Creators: name: Kozhberov, A. A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We study elastic properties of solid Yukawa systems. Elastic moduli and effective shear modulus of body-centered cubic (bcc) and face-centered cubic (fcc) lattices are obtained from electrostatic energies of deformed crystals. For the bcc lattice our results are well consistent with previous calculations and improve them, while results for the fcc lattice are new. We have also obtained an analytical expression of the elastic moduli for the weak polarization and constructed a convenient approximation for the higher polarization.
Post-mortem diagnosis of early myocardial ischemia and sudden cardiac death
Creators: name: Sabatasso, Sara
Publisher: name: Université de Genève
Year: 2020
Subjects: info:eu-repo/classification/ddc/614.1

description: Sudden cardiac death (SCD) represents a major priority for public health-care systems worldwide. Though early myocardial ischemia (EMI: ischemia during the initial 4 hours after interruption of coronary blood flow) is often a probable explanation for cardiac arrest in SCD cases, an established postmortem method for its diagnosis is still lacking. Within this series of investigations, diagnostic tools of EMI were evaluated in order to be applied in forensic (and clinical) pathology cases of SCD. EMI tissue markers were first investigated in an experimental model of myocardial ischemia (left anterior descending coronary artery ligation in rats) by using conventional methods (immunohistochemistry and Western blotting), as well as an advanced gene-expression investigation tool (nCounterÒ technology). Then they were evaluated in postmortem human cases of EMI and myocardial infarction (MI). These studies revealed the great interest of some tissue markers for the diagnosis of EMI in the experimental model, because of their early expression and sensitivity, as it was evidenced for dephosphorylated connexin 43 (Cx43) and JunB (expressed in ischemic rat myocardium as early as 15 and 30 minutes, respectively). On the other hand, when applied to human postmortem cases of EMI and MI these same markers lost their specificity, being expressed not only in cases of EMI and MI, but also in deaths by hanging (global hypoxia). Nonetheless, their tissular distribution in ischemia and global hypoxia revealed distinct patterns, with an expression localized in the subendocardium in ischemic cases and diffuse to all the myocardium in hypoxic cases. In another investigation, as a complementary diagnostic tool, we explored, with encouraging results, the feasibility of multi-phase postmortem CT angiography (MPMCTA) for the diagnosis of MI (visualized as a regional enhancement of the affected myocardium) and for guiding the sampling for histological analyses. In this panel of investigations we also introduce, for the first time in the field of MI diagnosis, an advanced technology (mass spectrometry immunohistochemistry: MS-IHC) for the simultaneous detection and quantification of multiple antibodies/markers (multiplexing) of MI/ischemia (troponin, myoglobin, fibronectin, C5b-9, dephosphorylated Cx43, JunB and VEGF-B) in the same tissue section. An exhaustive review on molecular changes occurring in the myocardium during EMI accomplishes the series of the studies presented in this thesis, highlighing the potential of some markers and providing an impulse for future investigations in the field.
DIRCEU PEREIRA SIQUEIRA.pdf
Creators: name: MARIA EDUARDA PIRES PETRIS
name: DIRCEU PEREIRA SIQUEIRA
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The theory of the Reserve Cause of the Possible was originated in Germany facing the conflict of the large number of Young people wishing to ingress the medical school and the limitation of vacancies offered by the State. This issue led to the creation of this theory because the German State had no financial means to afford the education to all who wanted to study Medicine. Thus, the reserve clauseof the possible Works, nowadays, as a valve to excuse the Governm ent from the obligations as a guarantor of the States, like it occurs in our Braziian legal system in which the Constitution guarantees the social rights. However, the lack of cohesion and harmony generates a negative impact to those who need the State as guarantor of their rights.
Additional file 1: of Factors influencing government insurance scheme beneficiary acceptance of the gatekeeper policy: a cross-sectional study in Wuhan, China
Creators: name: Li, Wenzhen
name: Wang, Dongming
name: Gan, Yong
name: Zhou, Yanfeng
name: Chen, Yawen
name: Li, Jing
name: Kkandawire, Naomiem
name: Hu, Sai
name: Qiao, Yan
name: Lu, Zuxun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: The detailed contents of the EUROPEP questionnaire. (DOC 29 kb)
Motivation letter for a summer school
Creators: name: Pedro, Raquel Sanchez De
Publisher: name: figshare
Year: 2017
Subjects: subject: 40501 Biological Oceanography
subject: FOS: Earth and related environmental sciences
subject: Environmental Science
subject: 40201 Exploration Geochemistry
subject: 60204 Freshwater Ecology
subject: FOS: Biological sciences
subject: Marine Biology

description: Motivation letter I used in my application to the ICBM Summer School 2013 - Biogeochemistry of tidal flats and beaches of the southern North Sea coast (Wadden Sea). (Granted)
From August 10 to 24, 2013 the Institute for Chemistry and Biology of the Marine Environment (ICBM, University of Oldenburg) organised a summer school on the “Biogeochemistry of tidal flats and beaches of the southern North Sea coast (Wadden Sea)”. The summer school was held at the Wittbülten Environmental Center on the island of Spiekeroog, and at ICBM facilities in Wilhelmshaven and Oldenburg.
A Global Charter for the Public's Health: a key tool to improve public health worldwide
Creators: name: Lomazzi, Marta
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/613
Global Health
Public Health
AMR
Pandemic

description: The Charter Global Charter for the Public's Health, developed by the World Federation of Public Health Associations (WFPHA) jointly with the WHO, is a comprehensive framework that can make a significant difference in public health and facilitate the global achievement of the SDGs and the global response to health threats. Antimicrobial resistance (AMR) is one of the main threats to health of our century. In this thesis, a real case scenario of the Global Charter for the Public's Health implementation in the anti-microbial resistance context is considered. The Global Charter for the Public's Health can pave the way for the global intersectoral actions needed to successfully tackle this threat. This can be achieved through the effective implementation of its core services (Prevention, Protection and Promotion) and its enabler functions (Information, Capacity, Advocacy and Governance).
Kunst über alle Künste, ein bös Weib gut zu machen : An Edition of the German Text
Year: 2022
Subjects: info:eu-repo/classification/ddc/420/820
William Shakespeare
Adaptation
German
Edition
Seventeenth century

description: This is an edition of "Kunst über alle Künste, ein bös Weib gut zu machen", a seventeenth-century German adaptation of Shakespeare's "The Taming of the Shrew" that appeared in print in 1672. The present edition of the German text constitutes a supplement to the Arden Shakespeare edition "Titus Andronicus and The Taming of the Shrew: Tito Andronico and Kunst über alle Künste, ein bös Weib gut zu machen in Translation", which contains an English translation, with full introduction and commentary, of the play.
ERIVALDO CAVALCANTI.pdf
Creators: name: ERIVALDO CAVALCANTI E SILVA FILHO
name: CARLA CRISTINA ALVES TORQUATO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This article illustrates the importance of water as an essential element for life of living beings, as well as its role as the object of disputes among the people, the state and utilities companies responsible for collection, treatment and subsequent distribution. The focus of the research was Manaus, a city that despite being intersected by streams and be located on the banks of the River Negro, has much of its population, specifically the Eastern and Northern areas, do not have regular water supply. We note that those responsible for this task, including the municipal government, are ineffective in fulfilling this mission. This difficulty does not happen only by operational difficulties, becoming apparent the occurrence of urban dispossession, the non-recognition of the needs of the lower classes to a right to the city. Sought through hierarchical selectivity of social policies theory, try to explain the model and why the incipient actions that are taken in municipal water management. Thus, it is not prudent to move away from the state management in the distribution network of water, especially in the poorest areas. The methodology used was the qualitative research is to identify and interpret the necessary information on the matter and establish descriptively investigated the phenomena in order to promote an analysis of its object, and the literature search, using doctrine and legal text.
Additional file 1: of Genetic analysis of Wnt/PCP genes in neural tube defects
Creators: name: Chen, Zhongzhong
name: Lei, Yunping
name: Cao, Xuanye
name: Zheng, Yufang
name: Wang, Fang
name: Bao, Yihua
name: Peng, Rui
name: Finnell, Richard
name: Zhang, Ting
name: Wang, Hongyan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Table S1. Demographic characteristics in NTD cohorts. (DOCX 17Â kb)
MOESM1 of Metabolic engineering of Corynebacterium glutamicum for efficient production of succinate from lignocellulosic hydrolysate
Creators: name: Mao, Yufeng
name: Li, Guiying
name: Chang, Zhishuai
name: Tao, Ran
name: Cui, Zhenzhen
name: Wang, Zhiwen
name: Tang, Ya-jie
name: Chen, Tao
name: Zhao, Xueming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1: Table S1. Primers used in this study.
Biomarkers for checkpoint inhibitors in NSCLC
Creators: name: Addeo, Alfredo
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616
NSCLC
ICI
Biomarker

description: Immune checkpoint inhibitors (ICPI) have dramatically shaped the treatment for non-small cell lung. We have witnessed durable responses which have led to unprecedented long for some patients, even in case of advanced or metastatic disease. Sadly, despite this incredible benefit the vast majority of the patients does not benefit or not substantially from being exposed to ICPI. Important downsides are the fact that some of the patients experience permanent and significant immunotoxicities. It has been therefore evident the need to better identify the patients who could more likely benefit for such a treatment. Thus biomarkers that predict response to therapy are a key aspect. Many studies have been published on different biomarkers to address this unmet need. For the time being the only one that has been prospectively validated is the tumor programmed death ligand 1(PD-L1) expression. The level of PD-L1 expression is determined by immunohistochemistry. PD-L1 expression has showed a strong correlation with treatment response and led to overall survival benefit. Several limitations about this biomarker exists, hence the need to develop further and more performing ones. The tumor mutational burden has emerged as possible alternative or complementary biomarker, and some studies have showed that knowing the mutation load of the cancer could predict the likelihood of response and benefit from immune checkpoint inhibitors. The importance played by mutations in specific genes has led to explore in depth gene expression signatures. Another biomarker under study is the density of tumor-infiltrating lymphocytes in the tumor microenvironment. Contradicting results have been seen and several studies are ongoing at the moment. Many biomarkers are linked to the presence of cancer tissue to carry further analysis. Several groups have worked on peripheral serum markers as a possible alternative to tissue based one. Another biomarker that remains controversial is the microbiota. Last but no least the application on artificial intelligence in this setting remains quite fascinating, even though no clear data had establish how this could be easily implemented in real practice. In this present work I have reviewed the evidence about the more promising biomarkers in order to clarify the present with a glimpse at the future.
Additional file 2: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity
Creators: name: Yang, Tianxiao
name: Wang, Yilin
name: Dai, Wenjuan
name: Zheng, Xixi
name: Wang, Jing
name: Song, Shushu
name: Fang, Lan
name: Zhou, Jiangfan
name: Wu, Weicheng
name: Gu, Jianxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Relationships between the B3GALNT2expression and the clinicopathological variables of hepatocellular carcinoma patients. (DOCX 20Â kb)
Direct 3D observation and unraveling of electroconvection phenomena during concentration polarization at ion-exchange membranes
Creators: name: Stockmeier, Felix
name: Schatz, Michael
name: Habermann, Malte
name: Linkhorst, John
name: Mani, Ali
name: Wessling, Matthias
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: A decade ago, two-dimensional microscopic flow visualization proved the theoretically predicted existence of electroconvection roles as well as their decisive role in destabilizing the concentration polarization layer at ion-selective fluid/membrane interfaces. Electroconvection induces chaotic flow vortices injecting volume having bulk concentration into the ion-depleted diffusion layer at the interface. Experimental quantification of these important flow patterns have so far only been carried out in 2D. Numerical direct simulations suggest 3D features, yet experimental proof is lacking. 3D simulations are also limited in covering extended spacial and temporal scales. This study presents a new comprehensive experimental method for the time-resolved recording of the 3D electroconvective velocity field near a cation-exchange membrane. For the first time, the spatio-temporal velocity field can be visualized in 3D at multiples of the overlimiting current density. In contrast to today's simulations, these experiments cover length and time scales typical for actual electrodialytic membrane processes. We visualize coherent vortex structures and reveal the changes in the velocity field and its statistics during the transition from vortex rolls to vortex rings with increasing current density. The transition is characterized by changes in the rotational direction, mean square velocity, and temporal energy spectrum with only little influence on the spatial spectrum. These findings indicate a more significant impact of EC's structural change on the mean square velocities and temporal spectra than on the spatial spectra. This knowledge is a prerequisite for engineering ion-selective surfaces that will enable the operation of electrically driven processes beyond the diffusion-limited Nernst regime.
Additional file 3: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity
Creators: name: Yang, Tianxiao
name: Wang, Yilin
name: Dai, Wenjuan
name: Zheng, Xixi
name: Wang, Jing
name: Song, Shushu
name: Fang, Lan
name: Zhou, Jiangfan
name: Wu, Weicheng
name: Gu, Jianxin
Publisher: name: figshare
Year: 2018
Subjects: Biological Sciences not elsewhere classified
Developmental Biology

description: Table S2. Univariate and multivariate Cox regression analysis for overall survival of hepatocellular carcinoma patients. (DOCX 20Â kb)
In-situ investigation of wetting patterns in polymeric multibore membranes via magnetic resonance imaging
Creators: name: Wypysek, Denis
name: Kalde, Anna Maria
name: Pradellok, Florian
name: Wessling, Matthias
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Wetting of the membrane to displace air or conditioning liquids is important to exploit the complex porosity of a filtration membrane. This study reveals the details of wetting in multibore membrane-based filtration modules. Using magnetic resonance imaging (MRI), we quantify the fluid distribution patterns during initial membrane wetting in dead-end permeation mode. The spatio-temporal evolution of aqueous copper sulfate solution wetting the membrane fibers was investigated as a function of the applied flux, packing density, and position along the membrane module length. Three initial wetting conditions were examined: delivery-state membranes, ethanol-washed and dried (air-filled) membranes, and ethanol-filled membranes. Significant changes in wetting patterns were observed due to interfacial and polymer swelling effects. This in-situ investigation reveals a slow wetting progression over six hours and more to obtain complete wetting, even at high fluxes of 200 LMH. However, an increased flux leads to faster wetting kinetics as the evolving wetting patterns are flux dependent. The packing density of the multibore fibers additionally impacts the wetting kinetics by shifting the prevalent pressure conditions. Although in dead-end mode, the wetting progression is non-uniform along the membrane module length. In addition to this parameter study, different pre-wetting agents' effect on the displacement behavior was investigated in depth. This study helps to understand (a) complex wetting phenomena inside multibore membranes in dead-end filtration, (b) the membranes' interaction with their surroundings due to neighboring membranes, and (c) the effect of the used fluid system for displacement on the resulting wetting patterns.
PAULO RAMOS.pdf
Creators: name: PAULO ROBERTO BARBOSA RAMOS
name: EDITH MARIA BARBOSA RAMOS
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The present article aimed to address, in an initial way, the idea of ​​human needs, on the one hand, as relative value and, on the other hand, as a determining process of life and whose realization constitutes an inalienable human right. The purpose of this paper was to highlight the fundamental nature of the discussion about universalizable ethical minimums in the conformation of the concept of needs, analyzing the different conceptual models of needs and stressing that basic needs have a relevant role in the recognition of a particular conception of society . From the theorizations developed by Santiago Nino (2007), Añón (2009), Roig and Lucas (1990), Nassbaum (1998), Nozick (1991), Williams (1985), Reichmann (1998), Zimmerling (1997), it has been observed that needs do not remain static all the time, but they grow, change and complicate themselves through human interactions and the political choices of the State, as a rule driven by market interests.
FREDERICO GLITZ.pdf
Creators: name: FELIPE STRASSACAPA
name: FREDERICO EDUARDO ZENEDIN GLITZ
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The present article analyzes the duty to mitigate the loss, that is the creditor duty to mitigate his own loss and his responsibility for not minimizing it. First, the article presents the principle that led to the duty to mitigate the loss itself. After that, the article presents the institute of the duty to mitigate the loss and which are the legal ground that justify its reception. Finally, the article addresses the responsibility for the breach of that duty.
MOESM1 of A structured understanding of cellobiohydrolase I binding to poplar lignin fractions after dilute acid pretreatment
Creators: name: Yao, Lan
name: Yoo, Chang
name: Meng, Xianzhi
name: Li, Mi
name: Pu, Yunqiao
name: Ragauskas, Arthur
name: Yang, Haitao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Sociology
subject: FOS: Sociology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Cardiology

description: Additional file 1: Figure S1. 2D-HSQC spectra and the main structures of the isolated lignins: (A) β-aryl-ether units (β-O-4); (B) phenylcoumarane; (C) resinols; (G) guaiacyl units; (S) syringyl units; (S’) oxidized syringyl units bearing a carbonyl at Cα; (PB) p-Hydroxybenzoate units. Condensed lignin was assigned from Sun et al. [8].
Abnormal results in common clinical laboratory assays: clues to diagnose rare inborn errors of metabolism?
Creators: name: Kern, Ilse
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616
info:eu-repo/classification/ddc/618
Metabolism
Inborn Errors
Clinical Laboratory Testing
Rare diseases

description: The highly specialized field of inborn errors of metabolism (IEM) goes hand in hand with laboratory medicine. Diagnosis and therapeutic monitoring of many IEMs require indeed highly specialized laboratory analyses that are only available in tertiary care and academic hospital facilities. Medical expertise regarding these orphan diseases is also often scarce outside specialized IEM reference centers. A few basic laboratory tests, that are widely available in most hospitals, may however give important hints to suspect an underlying IEM in “unusual” clinical situations. Thus, biochemical pathways governing the interplay of key intermediates of energy metabolism that are glucose, ketones and lactate are reviewed, as well as pathways influencing more organ specific biomarkers, such as ammonium, creatine kinase, homocysteine and uric acid. Clinical indications to prescribe each of these laboratory analyses and adequate handling of the biological samples are reviewed, since these are prerequisites to providing meaningful test results. The importance of following laboratory medicine good practice rules is discussed, since the increasing burden of overall medical costs puts pressure on physicians to optimize the way they request and interpret laboratory results. Examples of published algorithms that assist these processes will be shown, highlighting clinical and para-clinical constellations in which an underlying IEM should be suspected. Biochemistry is taught during the preclinical years of medical training but often neglected during further professional education. IEMs illustrate the links between basic sciences, clinical reasoning and treatment options in an outstanding, logical way. In order to illustrate the educational value of these rare “orphan” diseases, a few treatable IEMs that should come to mind when patients display abnormal results in the aforementioned common clinical biomarkers will be described. The field of IEMs is complex and requires very sophisticated laboratory tools; however, a sound knowledge of a few essential metabolic pathways and simple laboratory tools should allow any primary care physician to suspect a possible underlying IEM and take appropriate steps for further management and referral.
CLEIDE CALGARO.pdf
Creators: name: AGOSTINHO OLI KOPPE PEREIRA
name: CLEIDE CALGARO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: In the present work seeks to analyze the environmental impacts caused by hyperconsumption the environment in modern society. It is observed that even environmental conservation policies go through hiperconsumista bias, where "preserve is a possibility of profit." Thus, the development of public policies for local sustainability are proposed where citizens realize the importance of their actions for environmental preservation, because if these people having the feeling of belonging to the local space can contribute to minimizing impacts to the environment caused by unregulated consumer products.
Insights on congenital pulmonary and thoracic anomalies
Creators: name: Ruchonnet, Isabelle
Publisher: name: Université de Genève
Year: 2020
Subjects: info:eu-repo/classification/ddc/616.07
info:eu-repo/classification/ddc/618
Congenital pulmonary malformations
Congenital thoracic malformations
Translational studies
Proteomic

description: Congenital pulmonary and thoracic anomalies are rare malformations present from birth, with sometimes clinical manifestations later in life. Understanding the etiology of these malformations is important both for their management and for the anticipation of their clinical evolution. In this context, the study of embryogenesis and the various factors influencing pulmonary development could guide the therapeutic decisions proposed to these patients. The objective of this manuscript is to review the state of knowledge on the different pulmonary malformations from a clinical and translational standpoint and to discuss research perspectives. The manuscript includes five scientific papers. The one focuses on the tracheal bronchi observed from 5,970 children who underwent bronchoscopy for respiratory examinations. The subsequent results allowed improving clinical knowledge of such malformation. The second article is dedicated to the study of pulmonary hypoplasia in patients with congenital heart disease (CHD). Data obtained on 119 fetuses with CHD were prospectively examined for cardiac and pulmonary abnormalities. The results suggests that an altered interaction between endothelial cells, the surrounding epithelium and the mesenchyma could influence the development of pulmonary hypoplasia without an abnormality of the pulmonary vascular system. The third paper focuses on the potential neonatal consequences of congenital pulmonary anomalies (CPAM). The analysis of various parameters (ratio of maximum CPAM volume, polyhydramnios and ascites) is proposed to predict CPAM evolution and to define the requirement of a tertiary care center for delivery. The fourth paper describes the role and importance of a database and a related biobank in the study of rare diseases such as congenital pulmonary anomalies. The last article is dedicated to the study of paraffin-embedded samples of CPAM using immunostaining and proteomic analyses. Results show that there is no clear correlation between the CPAM origins and their onset during embryogenesis. The understanding of the interactions between lung cells during embryogenesis seems to be a key step to anticipate malformations to occur and to improve patient's follow-up. The papers included in this manuscript open new perspective for clinical and translational studies.
Additional file 1: of Chloroplast genome analyses and genomic resource development for epilithic sister genera Oresitrophe and Mukdenia (Saxifragaceae), using genome skimming data
Creators: name: Liu, Luxian
name: Wang, Yuewen
name: He, Peizi
name: Li, Pan
name: Lee, Joongku
name: Soltis, Douglas
name: Fu, Chengxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Hematology

description: Table S3. Locality and voucher information for populations of Oresitrophe rupifraga and Mukdenia rossii used in this study. Voucher specimens are deposited at the herbarium of Zhejiang University (HZU), Hangzhou, Zhejiang, China. (DOCX 17 kb)
IMLE-Net: An Interpretable Multi-level Multi-channel Model for ECG Classification
Creators: name: Reddy, Likith
name: Talwar, Vivek
name: Alle, Shanmukh
name: Bapi, Raju. S.
name: Priyakumar, U. Deva
Publisher: name: arXiv
Year: 2022
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Early detection of cardiovascular diseases is crucial for effective treatment and an electrocardiogram (ECG) is pivotal for diagnosis. The accuracy of Deep Learning based methods for ECG signal classification has progressed in recent years to reach cardiologist-level performance. In clinical settings, a cardiologist makes a diagnosis based on the standard 12-channel ECG recording. Automatic analysis of ECG recordings from a multiple-channel perspective has not been given enough attention, so it is essential to analyze an ECG recording from a multiple-channel perspective. We propose a model that leverages the multiple-channel information available in the standard 12-channel ECG recordings and learns patterns at the beat, rhythm, and channel level. The experimental results show that our model achieved a macro-averaged ROC-AUC score of 0.9216, mean accuracy of 88.85\%, and a maximum F1 score of 0.8057 on the PTB-XL dataset. The attention visualization results from the interpretable model are compared against the cardiologist's guidelines to validate the correctness and usability.
description: IEEE:SMC 2021
Additional file 2: of Chloroplast genome analyses and genomic resource development for epilithic sister genera Oresitrophe and Mukdenia (Saxifragaceae), using genome skimming data
Creators: name: Liu, Luxian
name: Wang, Yuewen
name: He, Peizi
name: Li, Pan
name: Lee, Joongku
name: Soltis, Douglas
name: Fu, Chengxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Hematology
subject: Plant Biology
subject: Virology

description: Figure S1. The distribution and presence of simple sequence repeats (SSRs) in the cp genome of Oresitrophe rupifraga-HNYD (A) and Mukdenia rossii (B). (PDF 392 kb)