cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ranking the Relative Importance of Toxicological Observations Based on Subject Matter Expertise
Creators: name: Proc. ISSST
name: Gust, Kurt A.
name: Mayo, Michael L.
name: Collier, Zachary A.
Publisher: name: figshare
Year: 2015
Subjects: Environmental Science

description: Toxicological investigations provide key observations for establishing potential impacts of chemicals and other materials in environmental exposures. The specific evaluation of chemical toxicity can be drawn from numerous lines of evidence, including, but, not limited to: lethality, sub-lethal impacts, toxicokinetics, critical tissue residues, molecular toxicology, reproductive impacts, mutation, carcinogenesis, decreased genetic diversity in populations and decreased species diversity. Despite this richness of potential observations, many predictive toxicological models, such as those included in life cycle impact assessment (LCIA), generally rely on one or a few ecotoxicity measures including median lethal concentrations (LC50) and no observed effects concentrations (NOECs). By excluding all but these composite effects metrics, such models often fail to accurately and/or robustly capture potential adverse outcomes that may negatively affect individual health, biological fitness and/or population sustainability. Although each has the potential to add value to chemical risk assessment, the relative importance of the various toxicological observations available for characterizing and assessing environmental impact has not been established. Therefore, we sought to establish the importance of multiple ecotoxicological lines of evidence for assessing environmental impacts. “Importance” in this context is a subjective valuation based on perceived utility within an assessment, therefore we developed and administered a survey to query subject matter experts (SMEs) in the fields of toxicology, ecotoxicology and risk assessment on the importance of a broad array of ecotoxicological measurements. This scoping study focused on SME opinions from Department of Defense scientists and risk assessors where 61 surveys were distributed and 21 returned and analyzed. Overall, observations from chronic exposures and reproductive endpoints were ranked the highest among SMEs while lines of evidence from in vivo studies outranked both in vitro and in silico observations.
Structure prediction and functional annotation of Chlamydia trachomatis hypothetical proteins of biological importance
Creators: name: Wan, Danny
Publisher: name: No Publisher Supplied
Year: 2023

description: Chlamydia trachomatis is an obligate intracellular bacterium pathogenic to humans and animals. Central to the pathogenicity of C. trachomatis is its unique developmental cycle, which alternates between two cellular forms: the infectious but non-proliferative elementary body and the proliferative but noninfectious reticulate body. C. trachomatis has a small genome which encodes about 900 proteins. The functions of nearly 200 chlamydial proteins remain unknown, but defining their functions is likely key to the understanding of the chlamydial developmental cycle. For my MS thesis, I employed cutting-edge computational tools to identify the functions of C. trachomatis hypothetical proteins with apparent importance in RNA synthesis, stress response, and plasmid replication. My research is presented in four chapters.In Chapter 1, I provide evidence that the hypothetical protein CTL0286 is the missing ω subunit of chlamydial RNA polymerase. Chapter 2 uncovers a potential molecular interaction between the novel heat-shock regulator HagF, and the heat-inducible transcriptional repressor HrcA. Chapters 3 offers evidence for the potential functions of hypothetical proteins whose expression are commonly regulated across different stress responses. Finally, chapter 4 assigns functions to proteins encoded by the virulence plasmid of C. trachomatis. The research presented here sheds light into the enigmatic functions of hypothetical proteins in C. trachomatis, elucidating their roles in important molecular and cellular processes in the pathogen. The revelations brought forth by this thesis not only elevate our field’s overall understanding of chlamydial biology but also demonstrate the value that can be derived by diving deep into uncharted territories of microbial genome using in silico tools. Much like a jigsaw puzzle, the insights gained about each protein presents additional puzzle pieces that help uncover the complete picture of chlamydial biology.
Additional file 1 of Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells
Creators: name: Purcell, Rachel V.
name: Permain, Jessica
name: Keenan, Jacqueline I.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Primer sequences used in the study.
Additional file 2 of Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells
Creators: name: Purcell, Rachel V.
name: Permain, Jessica
name: Keenan, Jacqueline I.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Table S1. IL-8 protein expression values from multiple ELISA analyses.
Operating system kernel data disambiguation to support security analysis
Creators: name: Ibrahim, Amani S.
name: Grundy, John
name: Hamlyn-Harris, James
name: Abdelrazek, Mohamed
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 460403
subject: Data security and protection
classificationCode: 460405
subject: Hardware security
classificationCode: 460406
subject: Software and application security
classificationCode: 460407
subject: System and network security
classificationCode: 460610
subject: Operating systems

description: It is very challenging to verify the integrity of Operating System (OS) kernel data because of its complex layout. In this paper, we address the problem of systematically generating an accurate kernel data definition for OSes without any prior knowledge of the OS kernel data. This definition accurately reflects the kernel data layout by resolving the pointer-based relations ambiguities between kernel data, in order to support systemic kernel data integrity checking. We generate this definition by performing static points-to analysis on the kernel's source code. We have designed a new points-to analysis algorithm and have implemented a prototype of our system. We have performed several experiments with real-world applications and OSes to prove the scalability and effectiveness of our approach for OS security applications.
Spectroscopy of globular clusters in the Fornax dwarf galaxy
Creators: name: Strader, Jay
name: Brodie, Jean
name: Forbes, Duncan
name: Beasley, Michael A.
name: Huchra, John P.
Publisher: name: Swinburne
Year: 2024

description: We present low-resolution, integrated Keck spectra of the five globular clusters (GCs) of the Fornax dwarf spheroidal galaxy. We find a tentative age spread among the clusters, with the GC H5 younger by 2-3 Gyr than the others. The clusters generally appear to be very metal-poor ([Fe/H] ∼ -1.8), with the cluster H4 slightly more metal-rich at [Fe/H] = -1.5. We speculate that cluster H4 is similar to the Galactic GC Ruprecht 106, which lacks the [α/Fe] enhancement typical among metal-poor GCs in the Milky Way. High-resolution spectroscopy of individual cluster and field stars will be needed to sort out the surprisingly complex history of GC formation and evolution in this galaxy.
Phyto- and biochemical study on cape gooseberry (physalis peruviana L.) extract incorporated with metal nanoparticles against hepatic injury induced in rats
Creators: name: Aboulthana, Wael Mahmoud
name: Omar, Nagwa Ibrahim
name: El-Feky, Amal Mohamed
name: Hassan, Amgad Kamal
name: Hasan, Enas Ahmed
name: Seif, Mohamed
name: Youssef, Ahmed Mahmoud
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: The study aimed to investigate the role of metal nanoparticles (M-NPs) in improving the efficiency of Physalis peruviana (Cape gooseberry) juice, which is rich in numerous important therapeutic phytochemicals. Therefore, it was subsequently studied against chemically-induced toxicity in rats. The present study demonstrated that C. gooseberry juice was used for the biosynthesis of silver (Ag-NPs) and zinc oxide nanoparticles (ZnO-NPs). The ZnO-C. gooseberry nano-extract exhibited higher in vitro biological activities compared to the other extracts. It was also found to be safer when administered orally. Moreover, it demonstrated a greater ameliorative effect against hepatotoxicity induced by carbon tetrachloride (CCl4) in rats. It restored the integrity of the liver tissue by increasing levels of antioxidant enzymes and reducing the inflammatory markers significantly (p ≤ 0.05). The study found that the ZnO-C. gooseberry nano-extract demonstrated greater efficacy in combating CCl4-induced hepatotoxicity compared to the other extracts.
The mediating role of organizational structure in the relationship between organizational culture and good sport governance in selected Ethiopian Olympic sports federations
Creators: name: Garmamo, Mengistu Galcho
name: Haddera, Tesfay Asgedom
name: Tola, Zeru Bekele
name: Jaleta, Matiwos Ensermu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The purpose of this study was to examine the mediating role of organizational structure in the relationship between organizational culture and good sport governance in selected Ethiopian Olympic sports federations. The cross-sectional survey design was employed to collect data through a structured questionnaire from 265 respondents randomly selected from six sports federations. The validity and reliability of the involved measures were examined through confirmatory factor, Cronbach’s alpha, and correlation analyses. A structural equation modeling analysis with maximum likelihood estimation was conducted to test the relationships among the research variables using SPSS AMOS 23.0. The results indicate that (1) organizational structure significantly mediates the influence of organizational culture on good sport governance (B=.16, P<.01, CI [.072-.297]); (2) organizational culture unexpectedly has a non-significant direct effect on good sport governance (B =.07, t-value =1.33, p >.05), and (3) organizational structure also has a significant direct effect on good sport governance (B =.20, t-value =4.30, p <.001). Hence, the findings of this study signify the need for a fit between culture and structure to tailor the beliefs, values, and attitudes of organizational members through the optimally framed organizational structure to good sport governance implementation in the surveyed sports federations.
Experimental analysis of task-based energy consumption in cloud computing systems
Creators: name: Chen, Fei Fei
name: Grundy, John
name: Yang, Yun
name: Schneider, Jean-Guy
name: He, Qiang
Publisher: name: Swinburne
Year: 2024

description: Cloud computing delivers IT solutions as a utility to users. One consequence of this model is that large cloud data centres consume large amounts of energy and produce significant carbon footprints. A common objective of cloud providers is to develop resource provisioning and management solutions that minimise energy consumption while guaranteeing Service Level Agreements (SLAs). In order to achieve this objective, a thorough understanding of energy consumption patterns in complex cloud systems is imperative. We have developed an energy consumption model for cloud computing systems. To operationalise this model, we have conducted extensive experiments to profile the energy consumption in cloud computing systems based on three types of tasks: computation-intensive, data-intensive and communicationintensive tasks. We collected fine-grained energy consumption and performance data with varying system configurations and workloads. Our experimental results show the correlation coefficients of energy consumption, system configuration and workload, as well as system performance in cloud systems. These results can be used for designing energy consumption monitors, and static or dynamic system-level energy consumption optimisation strategies for green cloud computing systems.
Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis
Creators: name: Enemchukwu, E
name: Mudd, Jr., P.N
name: Radican, L
name: Girman, C
name: Varano, S
name: Thai, S
name: Tee, S
name: Dmochowski, R.R
name: Poole, C
name: Iglay, K
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: Background/rationale: Long-term treatment with anticholinergic agents may increase the risk of cognitive impairment or dementia. This systematic literature review and meta-analysis aimed to assess the impact of ≥3 months of exposure to anticholinergics as a class on the risk of dementia, mild cognitive impairment, and change in cognitive function. The impact of anticholinergic agents specifically used to treat overactive bladder was also evaluated. Materials and Methods: A systematic literature review was conducted to identify English language articles evaluating the impact of anticholinergic use for ≥3 months on dementia or cognitive function in adult patients. Databases searched included PubMed, Embase, and the Cochrane Library. Meta-analyses were conducted using random-effects models; 95% confidence intervals (CIs) and 95% prediction intervals (PIs) were reported. Results: A total of 2122 records were identified. Out of those, 21 studies underwent qualitative synthesis and 6 reported endpoints relevant for inclusion in a meta-analysis assessing the risk of incident dementia. The overall rate ratio for incident dementia was 1.46 (95% CI: 1.17–1.81; 95% PI: 0.70–3.04; n = 6). The risk of incident dementia increased with increasing exposure (n = 3). In addition, two studies from the meta-analysis reported an increased risk of dementia with ≥3 months of use of bladder antimuscarinics (adjusted odds ratios ranged from 1.21 to 1.65, depending on exposure category). Conclusion: Anticholinergic use for ≥3 months increased the risk of dementia on average by an estimated 46% versus nonuse. This relationship was consistent in studies assessing overactive bladder medications. The risk of developing dementia should be carefully considered in the context of potential benefit before prescribing anticholinergics.
REInDetector: a framework for knowledge-based requirements engineering
Creators: name: Nguyen, Tuong Huan
name: Vo, Bao Quoc
name: Lumpe, Markus
name: Grundy, John
Publisher: name: Swinburne
Year: 2024

description: Requirements engineering (RE) is a coordinated effort to allow clients, users, and software engineers to jointly formulate assumptions, constraints, and goals about a software solution. However, one of the most challenging aspects of RE is the detection of inconsistencies between requirements. To address this issue, we have developed REInDetector, a knowledge-based requirements engineering tool, supporting automatic detection of a range of inconsistencies. It provides facilities to elicit, structure, and manage requirements with distinguished capabilities for capturing the domain knowledge and the semantics of requirements. This permits an automatic analysis of both consistency and realizability of requirements. REInDetector finds implicit consequences of explicit requirements and offers all stakeholders an additional means to identify problems in a more timely fashion than existing RE tools. In this paper, we describe the Description Logic used to capture requirements, the REInDetector tool, its support for inconsistency detection, and its efficacy as applied to several RE examples. An important feature of REInDetector is also its ability to generate comprehensive explanations to provide more insights into the detected inconsistencies.
title: Numerical investigation of the aeration process in the MBR system equipped with a flat sheet membrane module
Creators: name: Cao, Yingchen
Publisher: name: UNSPECIFIED
Year: 2020

description: This PhD study is devoted to numerically quantify the hydrodynamic characteristics in FS modules, such as shear stress distribution on the membrane surface and flow field distribution in membrane channels, under different operational and configurational conditions, so that it can provide some hints for the design and the operation of FS membrane modules. For this, interDyMFoam with the volume of fluid (VOF) method for modeling gas-liquid two-phase flow and the self-developed solver (interSolidFoam) coupled with the sludge models for modeling quasi gas-liquid-solid three-phase flow are adopted to simulate the ascent of single bubble and bubble swarms in FS membrane channels with the liquid medium of water and activated sludge, respectively. The critical parameters of the aeration process in FS modules, such as airflow rate, bubble size, superimposed liquid velocity, membrane channel depth, and MLSS concentration, are investigated in numerical models, and their effects are examined fundamentally. The models are validated against the experimental data from the literature in terms of bubble terminal rise velocity, and a good agreement is obtained between them. Numerical results reveal that the best performance is achieved at the narrowest membrane gap distance investigated, where the maximum shear stress is obtained under the same operational conditions. Therefore, it is recommended that the smallest membrane channel of 6 mm should be applied to the FS membrane modules for better membrane fouling control. Besides, the operational parameters affect the hydrodynamics in the FS membrane module significantly. Among all of the varied parameters, MLSS concentration, namely the rheology of non-Newtonian fluid, affects the bubble ascent behavior most. Airflow rate and superimposed liquid velocity are the parameters that have the most substantial influence regarding areaweighted shear stress, where a generally rising trend is observed with an increase in superimposed liquid velocity or an increase in airflow rate.
Вестник Российского нового университета серия «Сложные системы: модели, анализ, управление», Выпуск 12020
Creators: name: Автономная некоммерческая организация высшего образования «Российский новый университет»
Publisher: name: Вестник Российского нового университета серия «Сложные системы: модели, анализ, управление»
Year: 2020

description: , Выпуск 12020
AdvanceGender – Verbundprojekt für eine geschlechtersensible und intersektionale Forschung und Gesundheitsberichterstattung
Creators: name: Pöge, Kathleen
name: Rommel, Alexander
name: Mena, Emily
name: Holmberg, Christine
name: Saß, Anke-Christine
name: Bolte, Gabriele
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: Geschlecht
subject: Intersektionalität
subject: Gesundheitsberichterstattung
subject: Datenanalyse
subject: Studienteilnahme
subject: 610 Medizin und Gesundheit

description: Die Gesundheitsberichterstattung liefert aktuelle und detaillierte Informationen über die Gesundheit der Bevölkerung. Sie ist damit eine wichtige Grundlage für die Gesundheitspolitik und für die Forschung mit dem Ziel der Verbesserung von Gesundheitsförderung, Prävention und Versorgung. Um die gesellschaftliche Vielfalt besser abbilden zu können, zielt das vom Bundesministerium für Bildung und Forschung (BMBF) geförderte Verbundprojekt AdvanceGender auf die geschlechtersensible und intersektionale Weiterentwicklung des Forschungsprozesses populationsbasierter Studien und der Gesundheitsberichterstattung ab. Die drei Teilprojekte widmen sich inhaltlich der Studienteilnahme, Datenanalyse und der Gesundheitsberichterstattung. Aus den Ergebnissen werden Empfehlungen für epidemiologische Studien und für die Gesundheitsberichterstattung entwickelt.
D2.1 – Patient specific based phantom models
Creators: name: Kronreif, Gernot
name: Unger, Alexander
name: Kolonics, Richard
name: Capitanio, Umberto
name: Oleari, Elettra
name: Leporini, Alice
Publisher: name: Zenodo
Year: 2019
Subjects: phantoms
models
prostate
RARP Surgery

description: The document describes the different generations of the prostate phantom, discusses the achieved result in comparison with the requirements outlined in deliverable D7.1, and gives a short outlook over next iteration steps.
Learning from innovation through concept mapping
Creators: name: Leonard, Simon N.
name: Fitzgerald, Robert N.
name: Kohlhagen, Stuart
name: Murray, Aiden
Publisher: name: figshare
Year: 2015
Subjects: Design
Education

description: This is a paper to be presented at the Australian Association for Research in Education conference, December 2015. This paper reports on the use of conjecture mapping to identify the design principles of a 3D printing challenge conducted by Questacon, Australia’s National Science and Technology Centre. Conjecture mapping is a tool that has developed within design-research, also known as design-based research (DBR), an approach that seeks to increase the impact and transferability of educational research. Conjecture mapping assists in this goal by fully articulating the purpose of, and decision-making within, educational design. It shares much in common with other approaches to logic modelling, but specifically recognises that learning design involves conjecture of the activity that will be created, and further theoretical conjecture about how that activity leads to learning and change. It is through understanding this conjecture that the design principles of successful educational innovation can be initially identified, and so allow innovation to be transferred to other settings. By investigating the design features of the challenge, this paper finds that the embedded theoretical conjecture centred on improving significance and enactment. Significance is created by connecting participating students with engineers who use computer-aided design as part of their day-to-day work; while mind-body-world enactment is created by connected the learning to the activity in the physical world.
The Importance of Making Assumptions in Bias Analysis
Creators: name: Ahern, T.P
name: Poole, C
name: Maclehose, R.F
name: Lash, T.L
name: Greenland, S
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: Quantitative bias analyses allow researchers to adjust for uncontrolled confounding, given specification of certain bias parameters. When researchers are concerned about unknown confounders, plausible values for these bias parameters will be difficult to specify. Ding and VanderWeele developed bounding factor and E-value approaches that require the user to specify only some of the bias parameters. We describe the mathematical meaning of bounding factors and E-values and the plausibility of these methods in an applied context. We encourage researchers to pay particular attention to the assumption made, when using E-values, that the prevalence of the uncontrolled confounder among the exposed is 100% (or, equivalently, the prevalence of the exposure among those without the confounder is 0%). We contrast methods that attempt to bound biases or effects and alternative approaches such as quantitative bias analysis. We provide an example where failure to make this distinction led to erroneous statements. If the primary concern in an analysis is with known but unmeasured potential confounders, then E-values are not needed and may be misleading. In cases where the concern is with unknown confounders, the E-value assumption of an extreme possible prevalence of the confounder limits its practical utility.
MaramaAI: tool support for capturing and managing consistency of multi-lingual requirements
Creators: name: Kamalrudin, Massila
name: Grundy, John
name: Hosking, John
Publisher: name: Swinburne
Year: 2024

description: Requirements captured by Requirements Engineers are commonly inconsistent with their client's intended requirements and are often error prone especially if the requirements are written in multiple languages. We demonstrate the use of our automated inconsistency-checking tool MaramaAI to capture and manage the consistency of multi-lingual requirements in both the English and Malay languages for requirements engineers and clients using a round-trip, rapid prototyping approach.
title: Investigation into the structure and function of an amino acid efflux pump from E. coli
Creators: name: Cuce, Selale
Publisher: name: University of Kent
Year: 2025

description: Continual emergence of antimicrobial resistance has become a major global health crisis needing novel antimicrobial development. One potential approach we outline is targeting essential transporters, as these enact critical roles, particularly in preventing accumulation of toxic small molecules. Here we focus on an amino acid efflux pump in Escherichia coli called AlaE and evaluate its viability as a target by further structural and functional characterisation. For functional assessment we conducted both liquid and solid growth assays in M9 media with/without increasing concentrations of L-alanine and its derivatives and discovered that the derivatives were exponentially more inhibitory to alaE knockouts (JW2645-5), with 16 mM Ala-Ala and 8 mM Ala-Ala-Ala sufficient to be completely inhibitory. Re-introduction of the alaE gene showed recovery of growth comparable to that of the wild type (BW25113). Site directed mutagenesis alongside growth rescue assays were employed to determine residues of functional relevance in AlaE, including D14, R45, D64, D84, and D133. We developed methods of expression and purification to produce purified AlaE protein. Ligand binding was assessed via GFP-TS and DSF, with GFP-TS showing AlaE binding to L-alanine at 30 mM and 160 mM. Cysteine accessibility assay with mPEG5K determined AlaE’s cysteines to not be easily accessible. Our findings confirm that alaE is essential in the efflux of L-alanine and prevention of toxic accumulation in E. coli, as well as further current knowledge of functionally relevant residues and growth sensitivity characteristics. We present AlaE as a promising target for antimicrobial development.
Additional file 2 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 2: Figure S1. Protocol used in digital image analysis of carob seeds using ImageJ V1.53. A: Original image, B: 8-bit grayscale, C: Binary image. The scale bar represents 10 mm.
Additional file 1 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 1: Table S1. Geographic locations and climate of the 18 studied populations of Ceratonia siliqua L.
Additional file 3 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 3: Figure S2. Kernel density plot of carob seed traits depending on their geographic zone. A: Area, B: Perimeter, C: Width, D: Length, E: Circularity, F: Aspect ratio, G: Roundness. Different letters indicate significant differences (one-way ANOVA with Tukey post hoc method, P
Re-prioritizing traffic stops to reduce motor vehicle crash outcomes and racial disparities
Creators: name: Robinson, W
name: Poole, C
name: Marshall, S
name: Delamater, P
name: Baumgartner, F
name: Fliss, M.D
Publisher: name: BioMed Central Ltd.
Year: 2020

description: Background: Law enforcement traffic stops are one of the most common entryways to the US justice system. Conventional frameworks suggest traffic stops promote public safety by reducing dangerous driving practices and non-vehicular crime. Law enforcement agencies have wide latitude in enforcement, including prioritization of stop types: (1) safety (e.g. moving violation) stops, (2) investigatory stops, or (3) economic (regulatory and equipment) stops. In order to prevent traffic crash fatalities and reduce racial disparities, the police department of Fayetteville, North Carolina significantly re-prioritized safety stops. Methods: Annual traffic stop, motor vehicle crash, and crime data from 2002 to 2016 were combined to examine intervention (2013-2016) effects. Fayetteville was compared against synthetic control agencies built from 8 similar North Carolina agencies by weighted matching on pre-intervention period trends and comparison against post-intervention trends. Results: On average over the intervention period as compared to synthetic controls, Fayetteville increased both the number of safety stops + 121% (95% confidence interval + 17%, + 318%) and the relative proportion of safety stops (+ 47%). Traffic crash and injury outcomes were reduced, including traffic fatalities - 28% (- 64%, + 43%), injurious crashes - 23% (- 49%, + 16%), and total crashes - 13% (- 48%, + 21%). Disparity measures were reduced, including Black percent of traffic stops - 7% (- 9%, - 5%) and Black vs. White traffic stop rate ratio - 21% (- 29%, - 13%). In contrast to the Ferguson Effect hypothesis, the relative de-prioritization of investigatory stops was not associated with an increase in non-traffic crime outcomes, which were reduced or unchanged, including index crimes - 10% (- 25%, + 8%) and violent crimes - 2% (- 33%, + 43%). Confidence intervals were estimated using a different technique and, given small samples, may be asymmetrical. Conclusions: The re-prioritization of traffic stop types by law enforcement agencies may have positive public health consequences both for motor vehicle injury and racial disparity outcomes while having little impact on non-traffic crime.
Additional file 4 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 4: Table S2. One-way ANOVA test and Tukey HSD post hoc results of the studied carob populations according to their geographic origin.
In silico Spleen Tyrosine Kinase Inhibitor Screening by ChooseLD
Creators: name: Umeyama, Hideaki
name: Iwadate, Mitsuo
name: Taguchi, Y-H.
Publisher: name: figshare
Year: 2015
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Pharmacology

description: IPSJ Transactions on Bioinformatics Vol. 8 (2015) pp. 14-20
Universal nanodroplet branches from confining the Ouzo effect
Creators: Lu, Ziyang
Schaarsberg, Martin H. Klein
Zhu, Xiaojue
Zhang, Xuehua
Publisher: name: University of Alberta Library
Year: 2017

We report the self-organization of universal branching patterns of oil nanodroplets under the Ouzo effect [Vitale S, Katz J (2003) Langmuir 19:4105–4110]—a phenomenon in which spontaneous droplet formation occurs upon dilution of an organic solution of oil with water. The mixing of the organic and aqueous phases is confined under a quasi-2D geometry. In a manner analogous to the ramification of ground stream networks [Devauchelle O, Petroff AP, Seybold HF, Rothman DH (2012) Proc Natl Acad Sci USA 109: 20832–20836 and Cohen Y, et al. (2015) Proc Natl Acad Sci USA 112:14132–14137] but on a scale 10 orders of magnitude smaller, the angles between the droplet branches are seen to exhibit remarkable universality, with a value around 74° ± 2°, independent of the various control parameters of the process. Numerical simulations reveal that these nanodroplet branching patterns are governed by the interplay between the local concentration gradient, diffusion, and collective interactions. We further demonstrate the ability of the local concentration gradient to drive autonomous motion of colloidal particles in the highly confined space, and the possibility of using the nucleated nanodroplets for nanoextraction of a hydrophobic solute. The understanding obtained from this work provides a basis for quantitatively understanding the complex dynamical aspects associated with the Ouzo effect. We expect that this will facilitate improved control in nanodroplet formation for many applications, spanning from the preparation of pharmaceutical polymeric carriers, to the formulation of cosmetics and insecticides, to the fabrication of nanostructured materials, to the concentration and separation of trace analytes in liquid–liquid microextraction.
Additional file 5 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 5: Table S3. Mantel test results for the correlation between geographic variation with trait variation.
Femtosecond laser drilling of optical fibers for sensing in microuidic applications
Creators: name: Buividas, Richard
name: Mikutis, Mindaugas
name: Gervinskas, Gediminas
name: Day, Daniel
name: Šlekys, Gintas
name: Juodkazis, Saulius
name: Dobisz, Elizabeth A.
name: Eldada, Louay A.
Publisher: name: Swinburne
Year: 2024

description: We report on a technique for precise hole drilling in optical fibers using tightly focused femtosecond laser pulses. This direct laser writing approach makes it possible to minimize the amount of waveguide material for uncompromised mechanical performance of the fiber. The proof-of-the-principle of the fiber integration into a microfluidic chip is demonstrated. We show that fabricated holes in the waveguides can be used for measurement of absorption coefficient and refractive index changes at 1x10-3 refractive index units and 2 cm-1 for refractive index and absorption changes, respectively. Simple design and integration possibility of laser-fabricated waveguide sensors is prospective for optofluidic applications.
Commentary: Continuing the E-value's post-publication peer review
Creators: name: Poole, C
Publisher: name: Oxford University Press
Year: 2020

description: An association is taken seriously as possibly causal and then is found to have been the spurious spawn of one or more confounders, hitherto unknown and even unsuspected. This nightmarish scenario is possible, but how often has it actually occurred? For all the fear it engenders, one might think it has been commonplace in epidemiological history. One response to it is the E-value, a measure its developers have lobbied to become ‘standard practice’ and ‘reported routinely’ in ‘all observational studies intended to produce evidence for causality’.
Additional file 6 of Image analysis of Moroccan carob seeds (Ceratonia siliqua L.) revealed substantial intraspecific variations depending on climate and geographic origin
Creators: name: Kassout, Jalal
name: Hmimsa, Younes
name: El Fatehi, Salama
name: El Ouahrani, Abdeltif
name: Kadaoui, Khalil
name: Chakkour, Soufian
name: Ariza-Mateos, David
name: Palacios-Rodríguez, Guillermo
name: Navarro-Cerrillo, Rafael
name: Ater, Mohammed
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 6: Table S4. Trait loading, eigenvalues, and percentage of trait variation explained by the first three principal components (PCs).
title: Kinder, die ohne Filter fühlen
Creators: name: Becker, Alena Johanna
Year: 2024

description: Hochsensible Kinder zeigen oft ein geringeres Selbstwertgefühl im Kontext des zentralen Begriffs Selbstkonzept in der Psychomotorik. Aufgrund des steigenden Interesses an HS und des Mangels an Wissen und empirischen Daten in Verbindung von HS und Psychomotorik wird die Notwendigkeit betont, dieses Thema in der Forschung zu berücksichtigen, Verständnis aufzubauen und adäquate Förderansätze abzuleiten. Diese Masterarbeit untersucht, wie psychomotorische Interventionen das Selbstkonzept hochsensibler Kinder in der mittleren Kindheit stärken können. Die zentrale Forschungsfrage lautet: „Wie unterstützt die Psychomotorik hochsensible Kinder dabei, ein positives Selbstkonzept zu entwickeln und zu festigen?“ Dabei werden Wirksamkeit, Ansätze und gesellschaftliche Relevanz beleuchtet, um Fördermöglichkeiten für Selbstkonzept, Selbstvertrauen und Ressourcen hochsensibler Kinder zu identifizieren. HS, charakterisiert durch erhöhte sensorische Verarbeitungssensitivität, steht im Fokus als Persönlichkeitsmerkmal. Theoretisch beleuchtet die Arbeit die Relevanz und Förderung des Selbstkonzepts hochsensibler Kinder in der mittleren Kindheit. Die Psychomotorik bietet vielfältige Möglichkeiten zur positiven Beeinflussung des Selbstkonzepts auf verschiedenen Ebenen. Durch Spiel und Bewegung fördert sie die ganzheitliche Persönlichkeitsentwicklung, während die Atmosphäre und Haltung des/der Psychomotoriker*in Vertrauen, Sicherheit, Wertschätzung, Akzeptanz und Selbstwirksamkeit vermitteln. Die Betonung der Autonomie des Kindes und die Berücksichtigung seiner individuellen Bedürfnisse, Fähigkeiten, Stärken und Interessen stehen dabei im Mittelpunkt. In der mittleren Kindheit entwickeln Kinder durch soziale Interaktionen und Vergleiche ein umfassendes Selbstverständnis, das maßgeblich das Selbstkonzept beeinflusst. Die Ergebnisse zeigen, dass relevante Aspekte erfasst wurden, um das Selbstkonzept hochsensibler Kinder positiv zu beeinflussen. Sinnes- und Körpererlebnisse schaffen grundlegende Erfahrungen, die die Selbstinterpretation maßgeblich prägen. Die Psychomotorik bietet somit eine geeignete Rahmenbedingung zur Förderung des Selbstkonzepts hochsensibler Kinder.
White layer thickness prediction in WEDM-ANFIS modeling
Creators: name: Maher, Ibrahem
name: Sarhan, Ahmed A. D.
name: Houriyeh Marashi
name: Barzani, Mohsen Marani
name: M. Hamdi
Publisher: name: figshare
Year: 2015
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Applied Computer Science
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: Wire Electric Discharge Machining (WEDM) is a nontraditional technique by which the required profile is acquired using spark energy. Regarding wire cutting, precision machining is necessary to achieve high product quality. White Layer Thickness (WLT) is one of the most important factors for assessing superior surface finish. In this research, Adaptive Neuro-fuzzy Inference System (ANFIS) was used to predict the WLT in WEDM using coated wire electrode. The predicted data were compared with measured values, and the average prediction error for WLT was 2.61 %.
Evaluating the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on children’s quality of life, enjoyment and participation in physical activity
Creators: name: Hyndman, Brendon
Publisher: name: figshare
Year: 2015
Subjects: Environmental Science
Diseases
Health Care

description: Background: An emerging public health strategy is to enhance children’s opportunities to be physically active during school break periods. The aim of this study was to evaluate the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on primary school children’s quality of life (QOL), enjoyment and participation in physical activity (PA). Methods: This study consisted of a movable/recycled materials intervention that included baseline, a 7-week post-test and an 8-month follow-up data collection phase. Children within an intervention school (n = 123) and a matched control school (n = 152) aged 5-to-12-years-old were recruited for the study. Children’s PA was measured using a combination of pedometers and direct observation (SOPLAY). Quality of life, enjoyment of PA and enjoyment of lunchtime activities were assessed in the 8-12 year children. A multi-level mixed effect linear regression model was applied in STATA (version 12.0) using the xtmixed command to fit linear mixed models
to each of the variables to examine whether there was a significant difference (p < 0.05) between the intervention and control school at the three time points (pre, post and follow-up). Results: Significant overall interaction effects (group × time) were identified for children’s mean steps and distance (pedometers) in the intervention school compared to the control school. Intervention school children also spent significantly higher proportions within specified target areas engaged in higher PA intensities in comparison to the control school at both the 7-week post-test and 8-month follow-up. A short-term treatment effect was revealed after 7-weeks for children’s physical health scale QOL, enjoyment of PA and enjoyment of intra-personal play activities. Conclusions: Examining the effects of this school playground intervention over a school year suggested that the introduction of movable/recycled materials can have a significant, positive long-term intervention effect on children’s PA. The implications from this simple, low-cost intervention provide impetus for schools to consider introducing the concept of a movable/recycled materials intervention on a wider scale within primary school settings.
BO'LAJAK BOSHLANG'ICH TA'LIM O'QITUVCHISINING LIDERLIK QOBILIYATI  KASBIY KOMPETENSIYANI RIVOJLANTIRISHDAGI MUHIM OMIL SIFATIDA
Creators: name: Turaboyeva, M.R.
name: Habibullayeva, M.N.
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada zamonaviy jamiyat uchun bo‘lajak mutaxassislarning liderlik qobiliyatini egallash zaruriyati va liderlik qobiliyatini tarkibiy qismlari, rivojlantirish usullari haqida fikr yurutilgan. Shuningdek, talabalarda liderlik qobiliyatini rivojlantirish asosida ularning  kasbiy kompetensiyasini o‘stirishdasi muhim jihatlar xususida atroflicha mulohazalar bayon etilgan.
TASoMe: Validating a framework to generate evidence about health outcomes from social media use
Creators: name: Merolli, Mark
name: Gray, Kathleen
name: Martin-Sanchez, Fernando
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 420308
subject: Health informatics and information systems
classificationCode: 420310
subject: Health surveillance
classificationCode: 4299
subject: Other health sciences

description: Research surrounding social media's impact on patient-reported health outcomes continues to emerge. However, an ongoing challenge for researchers is generating valid and reliable evidence that draws upon rigorous frameworks. This manuscript details the development and refinement of a framework that defines criteria and methods for generating and evaluating evidence about social media use in chronic disease management; the Therapeutic Affordances of Social Media (TASoMe) framework. TASoMe was built through the considered combination of mixed research methods and data collection instruments. It represents a systematic methodology for conducting research that brings together the key concepts of: therapeutic affordances, patient-reported outcomes, and evidence-based practice to generate evidence about health outcomes from social media use. Its key building blocks include: the key research concepts, research methods, and stakeholders standing to benefit from outcomes. TASoMe contributes to the field of participatory health informatics by offering a stringent and reliable model for advancing research and practice. It has begun to be independently validated across a range of health conditions, and has the potential to be applied to a range of participatory health informatics technologies.