cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Wissensgraphen: Interdisziplinäre Perspektiven für Linked Data in den Geistes- und Sozialwissenschaften
Creators: name: Dörpinghaus, Jens
Publisher: name: Zeitschrift für digitale Geisteswissenschaften – ZfdG
Year: 2022

description: Wissensgraphen und Netzwerkansätze sind in ganz verschiedenen Disziplinen ein immer lebhafteres Forschungsthema. Dieser Artikel würdigt ihre parallele Entwicklung in Anwendung und Mathematik und die verschiedenen gegenwärtigen Ansätze zwischen Informatik, Mathematik, Data Science und den Geistes- und Sozialwissenschaften. Daraus ergeben sich zentrale interdisziplinäre Perspektiven: Erstens müssen die Netzwerkansätze in den Geistes- und Sozialwissenschaften breiter gefasst werden, da sich durch die Verwendung von Linked Data bereits implizit Wissensnetzwerke ergeben. Zweitens ergeben sich durch die methodische Breite von Wissensgraphen, in der beispielsweise soziale Netzwerke als Wissensgraphen aufgefasst werden können, neue Werkzeuge und neue Analysemethoden. Insofern versteht sich dieser Beitrag als Plädoyer für den interdisziplinären Austausch und eine vertiefte Diskussion über Methoden, Algorithmen und Linked Data Ansätze.
description:

Knowledge graphs and network approaches are an increasingly vibrant research topic in quite different disciplines. This article acknowledges their parallel development in applied and mathematical fields, and the various current approaches between computer science, mathematics, data science, and the humanities and social sciences. This gives rise to key interdisciplinary perspectives: first, network approaches in the humanities and social sciences need to be broader, as knowledge networks are already implicit in the use of Linked Data. Second, the methodological breadth of knowledge graphs, in which, for example, social networks can be conceived as knowledge graphs, results in new tools and new methods of analysis. In this respect, this paper is intended as a plea for interdisciplinary exchange and in-depth discussion of methods, algorithms, and Linked Data approaches.
Slab-derived devolatilization fluids oxidized by subducted metasedimentary rocks
Creators: name: Ague, Jay J.
name: Tassara, Santiago
name: Holycross, Megan E.
name: Li, Ji-Lei
name: Cottrell, Elizabeth
name: Schwarzenbach, Esther M.
name: Fassoulas, Charalampos
name: John, Timm
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy
subject: Petrology
subject: Volcanology
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Metamorphic devolatilization of subducted slabs generates aqueous fluids that ascend into the mantle wedge, driving the partial melting that produces arc magmas. These magmas have oxygen fugacities some 10–1,000 times higher than magmas generated at mid-ocean ridges. Whether this oxidized magmatic character is imparted by slab fluids or is acquired during ascent and interaction with the surrounding mantle or crust is debated. Here we study the petrology of metasedimentary rocks from two Tertiary Aegean subduction complexes in combination with reactive transport modelling to investigate the oxidative potential of the sedimentary rocks that cover slabs. We find that the metasedimentary rocks preserve evidence for fluid-mediated redox reactions and could be highly oxidized. Furthermore, the modelling demonstrates that layers of these oxidized rocks less than about 200 m thick have the capacity to oxidize the ascending slab dehydration flux via redox reactions that remove H2, CH4 and/or H2S from the fluids. These fluids can then oxidize the overlying mantle wedge at rates comparable to arc magma generation rates, primarily via reactions involving sulfur species. Oxidized metasedimentary rocks need not generate large amounts of fluid themselves but could instead oxidize slab dehydration fluids ascending through them. Proposed Phanerozoic increases in arc magma oxygen fugacity may reflect the recycling of oxidative weathering products following Neoproterozoic–Palaeozoic marine and atmospheric oxygenation.
Regulation of the Ca2+-ATPase by cholesterol: A specific or non-specific effect?
Creators: name: Autzen, Henriette Elisabeth
name: Siuda, Iwona
name: Sonntag, Yonathan
name: Nissen, Poul
name: Møller, Jesper Vuust
name: Thøgersen, Lea
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Like other integral membrane proteins, the activity of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) is regulated by the membrane environment. Cholesterol is present in the endoplasmic reticulum membrane at low levels, and it has the potential to affect SERCA activity both through direct, specific interaction with the protein or through indirect interaction through changes of the overall membrane properties. There are experimental data arguing for both modes of action for a cholesterol-mediated regulation of SERCA. In the current study, coarse-grained molecular dynamics simulations are used to address how a mixed lipid-cholesterol membrane interacts with SERCA. Candidates for direct regulatory sites with specific cholesterol binding modes are extracted from the simulations. The binding pocket for thapsigargin, a nanomolar inhibitor of SERCA, has been suggested as a cholesterol binding site. However, the thapsigargin binding pocket displayed very little cholesterol occupation in the simulations. Neither did atomistic simulations of cholesterol in the thapsigargin binding pocket support any specific interaction. The current study points to a non-specific effect of cholesterol on SERCA activity, and offers an alternative interpretation of the experimental results used to argue for a specific effect.
title: Generalisierungen als literarisches Phänomen. Charakterisierung, Annotation und automatische Erkennung
Creators: name: Gödeke, Luisa
name: Barth, Florian
name: Dönicke, Tillmann
name: Varachkina, Hanna
name: Weimer, Anna Mareike
name: Gittel, Benjamin
name: Holler, Anke
name: Holler, Anke
Publisher: name: Zeitschrift für digitale Geisteswissenschaften – ZfdG
Year: 2022

description: Generalisierungen in Erzähltexten dienen typischerweise nicht oder nicht ausschließlich dazu, die erzählte Welt aufzubauen, sondern um Informationen über die Erzählinstanz, den Sinn des Erzählten oder die reale Welt bereitzustellen. Der Aufsatz leistet einen Beitrag zur linguistisch-literaturwissenschaftlichen Beschreibung von Generalisierungen, entwickelt ein Tagset für ihre Identifikation und Klassifikation und stellt die Ergebnisse ihrer kollaborativen Annotation in einem diachronen Korpus (1616–1930) dar. Die schließlich vorgestellten regelbasierten und statistischen Tagger zur automatischen Erkennung von Generalisierungen gewährleisten den Zugang zu einer breiten Basis von Textbeispielen und ermöglichen eine empirisch gesättigte Analyse der Funktionen von Generalisierungen und der assoziierten narratologischen Phänomene.
description:

Generalisations in narrative texts typically do not or not exclusively serve to devise the narrated world, but provide information about the narrative instance, the meaning of what is told or the real world. The paper contributes to the linguistic-literary description of generalisations, develops a tagset for their identification and classification, and presents the results of their collaborative annotation in a diachronic corpus (1616–1930). Finally, the paper presents a rule-based and a statistical tagger for the automatic recognition of generalisations that allow users to access a variety of examples of the phenomenon and can be used in the analysis of the functions of generalisations and the associated narratological phenomena.
Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides
Creators: name: Umer, Husen M.
name: Audain, Enrique
name: Zhu, Yafeng
name: Pfeuffer, Julianus
name: Sachsenberg, Timo
name: Lehtiö, Janne
name: Branca, Rui
name: Perez-Riverol, Yasset
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: proteogenomics databases
subject: non-canonical peptides
subject: generation of protein sequences
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: We have implemented the pypgatk package and the pgdb workflow to create proteogenomics databases based on ENSEMBL resources. The tools allow the generation of protein sequences from novel protein-coding transcripts by performing a three-frame translation of pseudogenes, lncRNAs and other non-canonical transcripts, such as those produced by alternative splicing events. It also includes exonic out-of-frame translation from otherwise canonical protein-coding mRNAs. Moreover, the tool enables the generation of variant protein sequences from multiple sources of genomic variants including COSMIC, cBioportal, gnomAD and mutations detected from sequencing of patient samples. pypgatk and pgdb provide multiple functionalities for database handling including optimized target/decoy generation by the algorithm DecoyPyrat. Finally, we have reanalyzed six public datasets in PRIDE by generating cell-type specific databases for 65 cell lines using the pypgatk and pgdb workflow, revealing a wealth of non-canonical or cryptic peptides amounting to >5% of the total number of peptides identified.
Hepatoprotective phenylethanoid glycosides from Cirsium setosum
Creators: name: Qinge Ma
name: Yongming Guo
name: Baomin Luo
name: Wenmin Liu
name: Rongrui Wei
name: Chunxia Yang
name: Chenghua Ding
name: Xuefeng Xu
name: Minghui He
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3–8) were obtained from this plant for the first time.
title: Digitale Lernplattformen und Open Educational Resources im Altsprachlichen Unterricht I. Technische Spielräume am Beispiel des ›Grazer Repositorium antiker Fabeln‹ (GRaF)
Creators: name: Lang, Sarah
name: Spielhofer, Lukas
Publisher: name: Zeitschrift für digitale Geisteswissenschaften
Year: 2020

description: Die Frage nach dem Lehren und Lernen im digitalen Raum wurde von der Mediendidaktik in den vergangenen Jahren bereits ausführlich behandelt; digitale Methoden haben sich mittlerweile sowohl in der Forschung als auch im schulischen Umfeld mehr und mehr durchgesetzt. Dennoch wird den neu gewonnenen Erkenntnissen in der Theorie und Praxis der Vermittlung von Latein und Griechisch nach wie vor noch zu wenig Bedeutung zugemessen. Insbesondere das Gebiet der digitalen Lehr-/Lernressourcen bzw. der Open Educational Resources findet bisweilen eher wenig Beachtung in der Fachdidaktik der Klassischen Sprachen. Daher widmet sich dieser Beitrag, der Teil 1 einer interdisziplinär angelegten Untersuchung darstellt, diesem Medium zunächst von Seiten der Digital Humanities, um die technischen Spielräume digitaler Lehr-/Lernressourcen für die Anwendung im altsprachlichen Unterricht auszuloten und dabei insbesondere terminologisch-definitorische Fragestellungen in den Blick zu nehmen. Als Beispiel dafür dient die jüngst fertiggestellte digitale Fabel-Ausgabe ›Grazer Repositorium antiker Fabeln‹ (GRaF).
A new conditional performance score for the evaluation of adaptive group sequential designs with sample size recalculation
Creators: name: Herrmann, Carolin
name: Pilz, Maximilian
name: Kieser, Meinhard
name: Rauch, Geraldine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: adaptive group-sequential design
subject: clinical trial
subject: performance score
subject: sample size recalculation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In standard clinical trial designs, the required sample size is fixed in the planning stage based on initial parameter assumptions. It is intuitive that the correct choice of the sample size is of major importance for an ethical justification of the trial. The required parameter assumptions should be based on previously published results from the literature. In clinical practice, however, historical data often do not exist or show highly variable results. Adaptive group sequential designs allow a sample size recalculation after a planned unblinded interim analysis in order to adjust the sample size during the ongoing trial. So far, there exist no unique standards to assess the performance of sample size recalculation rules. Single performance criteria commonly reported are given by the power and the average sample size; the variability of the recalculated sample size and the conditional power distribution are usually ignored. Therefore, the need for an adequate performance score combining these relevant performance criteria is evident. To judge the performance of an adaptive design, there exist two possible perspectives, which might also be combined: Either the global performance of the design can be addressed, which averages over all possible interim results, or the conditional performance is addressed, which focuses on the remaining performance conditional on a specific interim result. In this work, we give a compact overview of sample size recalculation rules and performance measures. Moreover, we propose a new conditional performance score and apply it to various standard recalculation rules by means of Monte-Carlo simulations.
Enabling Building Information Model-Driven Human-Robot Collaborative Construction Workflows with Closed-Loop Digital Twins
Creators: name: Wang, Xi
name: Yu, Hongrui
name: McGee, Wes
name: Menassa, Carol C.
name: Kamat, Vineet R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: The introduction of assistive construction robots can significantly alleviate physical demands on construction workers while enhancing both the productivity and safety of construction projects. Leveraging a Building Information Model (BIM) offers a natural and promising approach to driving robotic construction workflows. However, because of uncertainties inherent in construction sites, such as discrepancies between the as-designed and as-built components, robots cannot solely rely on a BIM to plan and perform field construction work. Human workers are adept at improvising alternative plans with their creativity and experience and thus can assist robots in overcoming uncertainties and performing construction work successfully. In such scenarios, it is critical to continuously update the BIM as work processes unfold so that it includes as-built information for the ensuing construction and maintenance tasks. This research introduces an interactive closed-loop digital twin framework that integrates a BIM into human-robot collaborative construction workflows. The robot's functions are primarily driven by the BIM, but it adaptively adjusts its plans based on actual site conditions, while the human co-worker oversees and supervises the process. When necessary, the human co-worker intervenes to help the robot overcome the encountered uncertainties. A drywall installation case study is conducted to verify the proposed workflow. In addition, experiments are carried out to evaluate the system performance using an industrial robotic arm in a research laboratory setting that mimics a construction site and in the Gazebo simulation. Integrating the flexibility of human workers and the autonomy and accuracy afforded by the BIM, the proposed framework offers significant promise of increasing the robustness of construction robots in the performance of field construction work.
Is there an association between social determinants and care dependency risk? A multi‐state model analysis of a longitudinal study
Creators: name: Schneider, Alice
name: Blüher, Stefan
name: Grittner, Ulrike
name: Anton, Verena
name: Schaeffner, Elke
name: Ebert, Natalie
name: Jakob, Olga
name: Martus, Peter
name: Kuhlmey, Adelheid
name: Wenning, Volker
name: Schnitzer, Susanne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: activities of daily living
subject: care dependency
subject: cohort studies
subject: marital status
subject: proportional hazards models
subject: social determinants of health
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Despite a growing body of knowledge about the morbidities and functional impairment that frequently lead to care dependency, the role of social determinants is not yet well understood. The purpose of this study was to examine the effect of social determinants on care dependency onset and progression. We used data from the Berlin Initiative Study, a prospective, population-based cohort study including 2,069 older participants living in Berlin. Care dependency was defined as requiring substantial assistance in at least two activities of daily living for 90 min daily (level 1) or 3+ hours daily (level 2). Multi-state time to event regression modeling was used to estimate the effects of social determinants (partnership status, education, income, and sex), morbidities, and health behaviors, characteristics, and conditions. During the study period, 556 participants (27.5%) changed their status of care dependency. Participants without a partner at baseline were at a higher risk to become care-dependent than participants with a partner (hazard ratio [HR], 95% confidence interval [CI]: 1.24 (1.02-1.51)). After adjustment for other social determinants, morbidities and health behaviors, characteristics, and conditions the risk decreased to a HR of 1.19 (95% CI: 0.79-1.79). Results indicate that older people without a partner may tend to be at higher risk of care dependency onset but not at higher risk of care dependency progression. Clinicians should inquire about and consider patients' partnership status as they evaluate care needs.
Reflectance confocal microscopy for noninvasive examination of nonmelanocytic tumors and virus‐associated skin lesions in organ transplant recipients
Creators: name: Rueter, Lena
name: Ramadori, Pierluigi
name: Ulrich, Martina
name: Jung, Sora
name: Kardorff, Bernd
name: Lademann, Juergen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: basal cell carcinoma
subject: Bowen's disease
subject: epithelial skin cancer
subject: immununosuppression
subject: reflectance confocal microscopy
subject: verrucae
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Drug-induced immunosuppression is necessary to prevent rejection of the foreign organ in transplanted patients, but neoplastic and virus-associated skin diseases are frequent complications. Reflectance confocal microscopy (RCM) recently emerged as a promising tool for the early diagnosis of skin lesions. Materials and methods: A total of 61 skin lesions, among them 20 basal cell carcinomas, six Bowen's diseases, 23 actinic keratoses, and 12 verrucae, were analyzed. All lesions were clinically evaluated followed by RCM evaluation by two independent dermatologists and histological examination. Results: For the diagnosis of basal cell carcinoma, a sensitivity of 100% by both investigators (INV I + II) and a specificity of 100% by INV I and 80% by INV II were achieved. The sensitivity average rate for RCM features reached by both investigators ranged between 60% and 100%, and the specificity between 55% and 90%. For the diagnosis of actinic keratosis, a concordant sensitivity of 94.4% and a specificity of 80% (INV I) and 60% (INV II) were detected. The sensitivity average rate of specific RCM criteria ranged between 72.3% and 97.2%, whereas specificity ranged between 20% and 90%. Regarding verrucae, RCM confirmed the histological diagnosis with a sensitivity of 85.7% (INV I) and 100% (INV II), while specificity was 100% and 80%, respectively. Conclusion: Reflectance confocal microscopy resulted to be a reliable tool for the noninvasive diagnosis of neoplastic and virus-associated skin changes in organ transplant recipients. Nevertheless, given the frequency and diagnostic complexity of the hyperkeratotic lesions occurring post-transplantation, larger cohorts of patients are required to confirm and consolidate these findings.
Superconducting order parameter structure in the nematic phase of iron-based materials
Creators: name: Korshunov, M. M.
name: Togushova, Yu. N.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We consider the effect of the nematic order on the formation of the superconducting state in iron pnictides and chalcogenides. Nematic order with the $B_{2g}$ symmetry is modelled as the $d$-type Pomeranchuk instability and treated within the mean-field approach. Calculated nematic order parameter depends on the nematic interaction coefficient and abruptly changes with the coefficient's increase. The superconducting solution is obtained within the spin-fluctuation pairing theory. We show that the leading solution in the nematic phase has a $s_{π\pm}$ structure. From the critical temperature $T_c$ estimations, we conclude that the nematic superconducting state of the $s_{π\pm}$ type is more favorable than the usual $s_\pm$ and $d_{x^2-y^2}$ type states appearing in the absence of the nematicity.
description: 5 pages, published version
title: Digitale Lernplattformen und Open Educational Resources im Altsprachlichen Unterricht I. Technische Spielräume am Beispiel des ›Grazer Repositorium antiker Fabeln‹ (GRaF)
Creators: name: Lang, Sarah
name: Spielhofer, Lukas
Publisher: name: Zeitschrift für digitale Geisteswissenschaften - ZfdG
Year: 2022

description: Die Frage nach dem Lehren und Lernen im digitalen Raum wurde von der Mediendidaktik in den vergangenen Jahren bereits ausführlich behandelt; digitale Methoden haben sich mittlerweile sowohl in der Forschung als auch im schulischen Umfeld mehr und mehr durchgesetzt. Dennoch wird den neu gewonnenen Erkenntnissen in der Theorie und Praxis der Vermittlung von Latein und Griechisch nach wie vor noch zu wenig Bedeutung zugemessen. Insbesondere das Gebiet der digitalen Lehr-/Lernressourcen bzw. der Open Educational Resources findet bisweilen eher wenig Beachtung in der Fachdidaktik der Klassischen Sprachen. Daher widmet sich dieser Beitrag, der Teil 1 einer interdisziplinär angelegten Untersuchung darstellt, diesem Medium zunächst von Seiten der Digital Humanities, um die technischen Spielräume digitaler Lehr-/Lernressourcen für die Anwendung im altsprachlichen Unterricht auszuloten, dabei unter anderem terminologisch-definitorische Fragestellungen in den Blick zu nehmen und zu untersuchen, welche Konsequenzen technische Entscheidungen für den konkreten Unterrichtseinsatz haben können. Als Beispiel dafür dient die jüngst fertiggestellte digitale Fabel-Ausgabe ›Grazer Repositorium antiker Fabeln‹ (GRaF).
description: The topic of teaching and learning in digital spaces has already been discussed extensively in the past few years. By now, digital methods have been well established in both academic research and school education. However, the implementation of the recently gained insights from the field of media didactics into the theory and practice of teaching Greek and Latin has largely been neglected. Very little attention is paid in particular to the field of digital resources, Open Educational Resources respectively, when it comes to teaching methodology in Classics. Therefore, this article – as the first part of an interdisciplinary analysis – aims at approaching these digital media from a Digital Humanities point of view. It is primarily focused on terminology and definitions in order to determine the technical possibilities of digital educational resources for use in classes of classical philology. The only recently completed digital edition of the ›Grazer Repositorium antiker Fabeln‹ (GRaF) (›Graz repository of ancient fables‹) will be used as an example.
description: Es wurden folgende Änderungen vorgenommen: Inhaltliche Anpassungen, wie sie von den Gutachten angemerkt worden sind. Aktualisierung und Ergänzung der Fußnoten und der bibliografischen Angaben. Formale Korrekturen.
HiNeRV: Video Compression with Hierarchical Encoding-based Neural Representation
Creators: name: Kwan, Ho Man
name: Gao, Ge
name: Zhang, Fan
name: Gower, Andrew
name: Bull, David
Publisher: name: arXiv
Year: 2023
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Learning-based video compression is currently a popular research topic, offering the potential to compete with conventional standard video codecs. In this context, Implicit Neural Representations (INRs) have previously been used to represent and compress image and video content, demonstrating relatively high decoding speed compared to other methods. However, existing INR-based methods have failed to deliver rate quality performance comparable with the state of the art in video compression. This is mainly due to the simplicity of the employed network architectures, which limit their representation capability. In this paper, we propose HiNeRV, an INR that combines light weight layers with novel hierarchical positional encodings. We employs depth-wise convolutional, MLP and interpolation layers to build the deep and wide network architecture with high capacity. HiNeRV is also a unified representation encoding videos in both frames and patches at the same time, which offers higher performance and flexibility than existing methods. We further build a video codec based on HiNeRV and a refined pipeline for training, pruning and quantization that can better preserve HiNeRV's performance during lossy model compression. The proposed method has been evaluated on both UVG and MCL-JCV datasets for video compression, demonstrating significant improvement over all existing INRs baselines and competitive performance when compared to learning-based codecs (72.3% overall bit rate saving over HNeRV and 43.4% over DCVC on the UVG dataset, measured in PSNR).
Structural basis of adenylyl cyclase 9 activation
Creators: name: Qi, Chao
name: Lavriha, Pia
name: Mehta, Ved
name: Khanppnavar, Basavraj
name: Mohammed, Inayathulla
name: Li, Yong
name: Lazaratos, Michalis
name: Schaefer, Jonas V.
name: Dreier, Birgit
name: Bondar, Ana-Nicoleta
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Cell signalling
subject: Cryoelectron microscopy
subject: Enzyme mechanisms
subject: Membrane proteins
subject: Nucleotide-binding proteins
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus. Although our recent structural studies of the AC9-Gαs complex provided the framework for understanding AC9 autoinhibition, the conformational changes that AC9 undergoes in response to activator binding remains poorly understood. Here, we present the cryo-EM structures of AC9 in several distinct states: (i) AC9 bound to a nucleotide inhibitor MANT-GTP, (ii) bound to an artificial activator (DARPin C4) and MANT-GTP, (iii) bound to DARPin C4 and a nucleotide analogue ATPαS, (iv) bound to Gαs and MANT-GTP. The artificial activator DARPin C4 partially activates AC9 by binding at a site that overlaps with the Gαs binding site. Together with the previously observed occluded and forskolin-bound conformations, structural comparisons of AC9 in the four conformations described here show that secondary structure rearrangements in the region surrounding the forskolin binding site are essential for AC9 activation.
title: Die Digitalisierung des goldenen Zeitalters - Editionsproblematik und stilometrische Autorschaftsattribution am Beispiel des Quijote
Creators: name: Rißler-Pipka, Nanette
Publisher: name: Zeitschrift für digitale Geisteswissenschaften – ZfdG
Year: 2022

description: Spaniens Goldenes Zeitalter scheint wie geschaffen für die quantitative Textanalyse. Gibt es doch zahlreiche Texte und verschiedene Editionen in digitalisierter Form in Virtuellen Bibliotheken wie die bekannte BVMC (Biblioteca Virtual Miguel de Cervantes). Allerdings braucht man für stilometrische Analysen nicht nur den Text selbst, sondern auch korrekte und vollständige Metadaten. Da schon die zeitgenössischen Editionen des Goldenen Zeitalters nur schwer bezüglich der Textqualität zu überprüfen sind, werden zusätzliche Informationen (die sogenannten Metadaten) zu Text, Autor, Entstehungsdatum und -ort umso wichtiger. Im Folgenden wird die verfügbare Textgrundlage für stilometrische Analysen problematisiert und am Beispiel von Autorschaftsattributionen für den apokryphen zweiten Band des Quijote von Avellaneda (Pseudonym) angewendet. Das Ziel ist dabei nicht die wahre Identität Avellanedas aufzudecken, sondern die Methode mit verschiedenen Parametern (cosine Delta, eingeschränkte Wortliste, Culling, rolling Delta) zu testen und die Ergebnisse im Kontext anderer Methoden zur Autorschaftsattribution sowie im Kontext der traditionellen Literaturgeschichte und -wissenschaft zu diskutieren.
description: For quantitative literary analysis, the Spanish Golden Age seems to be a perfect field of research. Many texts are provided by Virtual Libraries like the most known BVMC (Biblioteca Virtual Miguel de Cervantes) in various editions. Though for textual analysis like stylometry not only the text itself, but also the metadata should be complete and correct. As the contemporary editions of the Golden Age are themselves difficult to judge regarding the textual originality, additional information (usually called metadata) about the origin of text, author, date, place is needed. The following paper discusses the problem of existing textual basis for stylometric analysis using the example of authorship attribution for the apocryphal second volume of the Quijote by Avellaneda (pseudonym). The aim is not to discover the real identity of the author Avellaneda, but to test the method with various parameters (cosine Delta, selected wordlist, culling, rolling Delta) and to discuss the results in the context of other existing authorship attributional methods and in the context of traditional working literary history and studies.
CompanyKG: A Large-Scale Heterogeneous Graph for Company Similarity Quantification
Creators: name: Cao, Lele
name: von Ehrenheim, Vilhelm
name: Granroth-Wilding, Mark
name: Stahl, Richard Anselmo
name: McCornack, Andrew
name: Catovic, Armin
name: Rocha, Dhiana Deva Cavacanti
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Databases (cs.DB)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: E.0; I.2.1; I.2.6; H.4.0; J.0; I.2.8; I.2.7
subject: 05C85, 05C12, 68T07, 68T50, 05C90

description: In the investment industry, it is often essential to carry out fine-grained company similarity quantification for a range of purposes, including market mapping, competitor analysis, and mergers and acquisitions. We propose and publish a knowledge graph, named CompanyKG, to represent and learn diverse company features and relations. Specifically, 1.17 million companies are represented as nodes enriched with company description embeddings; and 15 different inter-company relations result in 51.06 million weighted edges. To enable a comprehensive assessment of methods for company similarity quantification, we have devised and compiled three evaluation tasks with annotated test sets: similarity prediction, competitor retrieval and similarity ranking. We present extensive benchmarking results for 11 reproducible predictive methods categorized into three groups: node-only, edge-only, and node+edge. To the best of our knowledge, CompanyKG is the first large-scale heterogeneous graph dataset originating from a real-world investment platform, tailored for quantifying inter-company similarity.
description: CompanyKG (version 1.x). Published by IEEE Transactions on Big Data (12 pages, 10 figures and 2 tables) + Appendix (9 pages, 1 figures and 4 tables). Code: https://github.com/EQTPartners/CompanyKG ; Data: https://zenodo.org/record/8010239
High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation
Creators: name: Zhang, Xiaoli
name: Hasan, Ahmed A.
name: Wu, Hongwei
name: Gaballa, Mohamed M. S.
name: Zeng, Suimin
name: Liu, Liping
name: Xie, Li
name: Jung, Tobias
name: Grune, Tilman
name: Kleuser, Burkhard
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: epigenetics
subject: high-fat-sucrose-salt diet
subject: kidney function
subject: paternal programming
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Effects of feeding male rats during spermatogenesis a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on renal outcomes are unknown. Male F0 and F1 rats were fed either control diet (F0CD+F1CD) or HFSSD (F0HD+F1HD). The outcomes were glomerular filtration rate and urinary albumin excretion in F1 and F2 offspring. If both outcomes were altered a morphological and molecular assessment was done. F2 offspring of both sexes had a decreased GFR. However, increased urinary albumin excretion was only observed in female F2 F0HD+F1HD offspring compared with controls. F0HD+F1HD female F2 offspring developed glomerulosclerosis (+31%; p < .01) and increased renal interstitial fibrosis (+52%; p < .05). RNA sequencing followed by qRT-PCR validation showed that four genes (Enpp6, Tmem144, Cd300lf, and Actr3b) were differentially regulated in the kidneys of female F2 offspring. lncRNA XR-146683.1 expression decreased in female F0HD+F1HD F2 offspring and its expression was (r = 0.44, p = .027) correlated with the expression of Tmem144. Methylation of CpG islands in the promoter region of the Cd300lf gene was increased (p = .001) in female F2 F0HD+F1HD offspring compared to controls. Promoter CpG island methylation rate of Cd300lf was inversely correlated with Cd300lf mRNA expression in F2 female offspring (r = −0.483, p = .012). Cd300lf mRNA expression was inversely correlated with the urinary albumin-to-creatinine ratio in female F2 offspring (r = −0.588, p = .005). Paternal pre-conceptional unhealthy diet given for two generations predispose female F2 offspring to chronic kidney disease due to epigenetic alterations of renal gene expression. Particularly, Cd300lf gene promotor methylation was inversely associated with Cd300lf mRNA expression and Cd300lf mRNA expression itself was inversely associated with urinary albumin excretion in F2 female offspring whose fathers and grandfathers got a pre-conceptional unhealthy diet.
Assessing the influence of diurnal variations and selective Xa inhibition on whole blood aggregometry
Creators: name: Jilma, Bernd
name: Schoergenhofer, Christian
name: Schwameis, Michael
name: Brunner, Martin
name: Zeitlinger, Markus
name: Winkler, Felix
name: Brunner-Ziegler, Sophie
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Science Policy
Biological Sciences
Chemistry
Pharmacology
Engineering
Biochemistry

description: A biological rhythm in platelet function is well known. Multiple electrode aggregometry (MEA) is a widely used assay to measure platelet aggregability. Rivaroxaban is a new oral anticoagulant frequently used in an increasing number of indications. In this randomized, crossover trial we investigated whether a biological rhythm exists in MEA measurements and potential effects of rivaroxaban on platelet aggregation. Sixteen healthy volunteers were included in the study and blood samples were obtained at 08:00, 12:00, 16:00 and 20:00 h. Each subject was tested without rivaroxaban intake first and randomly assigned to 3 days of rivaroxaban intake at 08:00 or 3 days of rivaroxaban intake at 20:00 h and vice versa. In MEA measurements, a significant increase in platelet aggregation after addition of ristocetin at 12:00 h compared to other investigated time-points (122 ± 8 AU at 12:00 h vs. 109 ± 9 AU at 08:00 h, 114 ± 10 AU at 16:00 h and 103 ± 8 AU at 20:00 h, p = 0.027) could be detected. There was no biological rhythm detectable using other agonists (ADP, arachidonic acid, thrombin-receptor activating peptide-6). After rivaroxaban intake at 08:00 h an increased ristocetin-induced platelet aggregation was measured in the next morning (126 ± 4 AU (rivaroxaban at 08:00 h) vs. 109 ± 9 AU (no rivaroxaban), 111 ± 6 AU (rivaroxaban at 20:00 h; p = 0.002). No other effects of rivaroxaban on platelet function were found. We detected a biological rhythm in ristocetin-induced platelet aggregation with a peak at 12:00 h (noon). No influence of selective Xa inhibition on platelet aggregation was detected.
Fibre optic distributed acoustic sensing of volcanic events
Creators: name: Jousset, Philippe
name: Currenti, Gilda
name: Schwarz, Benjamin
name: Chalari, Athena
name: Tilmann, Frederik
name: Reinsch, Thomas
name: Zuccarello, Luciano
name: Privitera, Eugenio
name: Krawczyk, Charlotte M.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: Volcanology
subject: Geology
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Understanding physical processes prior to and during volcanic eruptions has improved significantly in recent years. However, uncertainties about subsurface structures distorting observed signals and undetected processes within the volcano prevent volcanologists to infer subtle triggering mechanisms of volcanic phenomena. Here, we demonstrate that distributed acoustic sensing (DAS) with optical fibres allows us to identify volcanic events remotely and image hidden near-surface volcanic structural features. We detect and characterize strain signals associated with explosions and locate their origin using a 2D-template matching between picked and theoretical wave arrival times. We find evidence for non-linear grain interactions in a scoria layer of spatially variable thickness. We demonstrate that wavefield separation allows us to incrementally investigate the ground response to various excitation mechanisms. We identify very small volcanic events, which we relate to fluid migration and degassing. Those results provide the basis for improved volcano monitoring and hazard assessment using DAS.
In vivo detection of changes in cutaneous carotenoids after chemotherapy using shifted excitation resonance Raman difference and fluorescence spectroscopy
Creators: name: Jung, Sora
name: Darvin, Maxim E.
name: Schleusener, Johannes
name: Thiede, Gisela
name: Lademann, Juergen
name: Braune, Marcel
name: Maiwald, Martin
name: Sumpf, Bernd
name: Tränkle, Günther
name: Kutzer, Dunja
name: Elban, Felia
name: Fuss, Harald
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: carotenoids
subject: chemotherapy
subject: fluorescence
subject: Raman difference spectroscopy
subject: shifted excitation resonance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Various cutaneous toxicities under chemotherapy indicate a local effect of chemotherapy by secretion after systemic application. Here, changes in the fluorescence and Raman spectral properties of the stratum corneum subsequent to intravenous chemotherapy were assessed. Methods: Twenty healthy subjects and 20 cancer patients undergoing chemotherapy were included. Measurement time points in cancer patients were before the first cycle of chemotherapy (Tbase) and immediately after intravenous application of the chemotherapy (T1). Healthy subjects were measured once without any further intervention. Measurements were conducted using an individually manufactured system consisting of a handheld probe and a wavelength-tunable diode laser-based 488 nm SHG light source. Hereby, changes in both skin fluorescence and shifted excitation resonance Raman difference spectroscopy (SERRDS) carotenoid signals were assessed. Results: Healthy subjects showed significantly (P < .001) higher mean concentrations of carotenoids compared to cancer subjects at Tbase. An increase in fluorescence intensity was detected in almost all patients after chemotherapy, especially after doxorubicin infusion. Furthermore, a decrease in the carotenoid concentration in the skin after chemotherapy was found. Conclusion: The SERRDS based noninvasive detection can be used as an indirect quantitative assessment of fluorescent chemotherapeutics. The lower carotenoid SERRDS intensities at T(base) might be due to cancerous diseases and co-medication.
The nonparametric Behrens‐Fisher problem with dependent replicates
Creators: name: Roy, Akash
name: Harrar, Solomon W.
name: Konietschke, Frank
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: asymptotics
subject: clustered data
subject: empirical distribution
subject: nonparametric effects
subject: ranks
subject: two-sample problem
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purely nonparametric methods are developed for general two-sample problems in which each experimental unit may have an individual number of possibly correlated replicates. In particular, equality of the variances, or higher moments, of the distributions of the data is not assumed, even under the null hypothesis of no treatment effect. Thus, a solution for the so-called nonparametric Behrens-Fisher problem is proposed for such models. The methods are valid for metric, count, ordered categorical, and even dichotomous data in a unified way. Point estimators of the treatment effects as well as their asymptotic distributions will be studied in detail. For small sample sizes, the distributions of the proposed test statistics are approximated using Satterthwaite-Welch-type t-approximations. Extensive simulation studies show favorable performance of the new methods, in particular, in small sample size situations. A real data set illustrates the application of the proposed methods.
Osteocartilaginous metabolic markers change over a 3-week stage race in pro-cyclists
Creators: name: Corsetti, Roberto
name: Sansoni, Veronica
name: Barassi, Alessandra
name: Banfi, Giuseppe
name: Lombardi, Giovanni
name: Perego, Silvia
name: Jincheng Xu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physiology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Evidence suggests that endurance and even recreational cycling may stimulate bone resorption; however, little is known about cartilage response to endurance cycling exercise. We investigated effort-dependent changes in bone turnover and cartilage biomarkers in blood and urine samples from elite cyclists during a 3-week stage race. Whole blood and urine samples were collected the day before the start of the race, at mid and end-race for serum and urinary CTx-I, NTx-I, PINP, COMP (only in serum), and CTx-II analysis by enzyme-linked immunosorbent assay. The values were corrected for plasma volume or creatinine excretion, respectively, and correlated with power output (corrected for body weight) and net energy expenditure. Bone marker concentrations in both serum and urine were slightly but significantly decreased. Among the cartilage degradation markers, only CTx-II was decreased, while COMP remained unchanged. The changes in bone and cartilage turnover indexes were correlated with the indexes of physical effort and energy consumption.Strenuous physical effort, in the absence of mechanical loading, slows bone metabolism and only minimally affects cartilage turnover. Since changes in plasma and urine volume, which normally occur in exercising athletes, can mask these effects, biomarker concentrations need to be corrected for shifts in plasma volume and urinary creatinine for correct interpretation of the data.
title: Historisches Lehren und Lernen mit digitalisierten Quellen. Zum Potenzial der Historischen Grundwissenschaften in der Lehrerbildung
Creators: name: Kreutz, Jessica
Publisher: name: Zeitschrift für digitale Geisteswissenschaften – ZfdG
Year: 2022

description: In diesem Beitrag werden Chancen und Herausforderungen der digitalen Bildung im Kontext der Lehrerbildung diskutiert. Im Fokus stehen digitalisierte Quellen, durch deren gezielten Einsatz Lehrerinnen und Lehrer im Geschichtsunterricht bei Schülerinnen und Schülern historisches Denken und Lernen fördern können. Die Verwendung von digitalen Reproduktionen historischer Quellen zieht einen ganzheitlichen und authentischen Umgang mit Quellen nach sich, da diese gleichermaßen als Sachquelle, Bildquelle und Textquelle in ihrer ursprünglichen Überlieferungsform bearbeitet werden können. Den Methoden der Historischen Grundwissenschaften als Teilgebiet der Geschichtswissenschaft kommen bei der schulischen Arbeit mit digitalisierten Quellen daher eine zentrale Rolle zu. Ziel ist es aufzuzeigen, welche Rolle die Historischen Grundwissenschaften bei der Arbeit mit digitalisierten Quellen im Hinblick auf den Prozess historischen Lernens haben und welche Notwendigkeit sich daraus für die Geschichtslehrerausbildung ergibt.
description: Historical teaching and learning with digitized sources, dealing with databases in the context of the digitization strategy – this paper discusses opportunities and challenges of digital education in the context of teacher training. The focus is on digital databases that teachers can use to assist their students in dealing with historical sources through targeted use in history lessons. The use of digital reproductions of historical sources allows a holistic and authentic approach to sources, since they can be treated equally as objects, pictures and texts. The methods of auxiliary sciences, as a branch of history science, therefore play a central role in history didactics. The aim is not only to show what added value digital databases have in the process of historical thinking and learning.
description: Version 2.0 (14.11.2022)

Es wurden folgende Änderungen vorgenommen: Inhaltliche Anpassungen, wie sie von den Gutachten angemerkt worden sind. Aktualisierung und Ergänzung der bibliographischen Angaben. Formale Korrekturen.