cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Increases radiation dose for chest CT scan in COVID-19
Creators: name: cristofaro, massimo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radioprotection / Radiation dose
subject: CT
subject: Technical aspects
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The diagnostic imaging with a chest CT in patients with COVID-19 pneumonia is the key point for early screening, differential diagnosis, staging, the severity of the disease and to plan the possible therapy in the intensive care unit. The evolution...
Complex Langevin dynamics for dynamical QCD at nonzero chemical potential: a comparison with multi-parameter reweighting
Creators: name: Fodor, Z.
name: Katz, S. D.
name: Sexty, D.
name: Török, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study lattice QCD at non-vanishing chemical potential using the complex Langevin equation. We compare the results with multi-parameter reweighting both from $μ=0$ and phase quenched ensembles. We find a good agreement for lattice spacings below $\approx$0.15 fm. On coarser lattices the complex Langevin approach breaks down. Four flavors of staggered fermions are used on $N_t=4, 6$ and 8 lattices. For one ensemble we also use two flavors to investigate the effects of rooting.
description: 10 pages, 11 figures, PRD version, minor changes
Enhancing the use of Haptic Devices in Education and Entertainment
Creators: name: BALZAROTTI, NICOLO'
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: This research was part of the two-years Horizon 2020 European Project "weDRAW". The aim of the project was that "specific sensory systems have specific roles to learn specific concepts". This work explores the use of the haptic modality, stimulated by the means of force-feedback devices, to convey abstract concepts inside virtual reality. After a review of the current use of haptic devices in education, available haptic software and game engines, we focus on the implementation of an haptic plugin for game engines (HPGE, based on state of the art rendering library CHAI3D) and its evaluation in human perception experiments and multisensory integration.
title: III. Noun Group Problems II – Probleme der Nominalgruppe II
title: Linguistic research in progress (Part III, Winter Semester 1992/93)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
title: IX. Valence and Government II – Valenz und Rektion II
title: Linguistic research in progress (Part IX, Summer Semester 1997)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
Skyrme-like models and supersymmetry in 3+1 dimensions
Creators: name: Queiruga, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct supersymmetric extensions for different Skyrme-like models in 3+1 dimensions. BPS equations and BPS bounds are obtained from supersymmetry in some cases. We discuss also the emergence of several Skyrme-like models from supersymmetric Yang-Mills theory and Born-Infeld theory in 5 dimensions.
description: 36 pages, typos corrected. Version to appear in PRD
Functional Characterization of Mesenchymal Stromal Cell- Derived Extracellular Vesicles
Creators: name: GORGUN, CANSU
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Mesenchymal Stromal Cells (MSCs) are currently considered a powerful tool for the treatment of multiple diseases. Indeed, the original hypothesis underlying MSC based regenerative therapies was based on functional recovery as a consequence of stem cell differentiation. But it is now clear that other mechanisms of action are involved. The recent emerging paradigm shift suggests that the paracrine effects of MSCs may be as important as cell differentiation in eliciting functional tissue repair. Among the factors responsible for the paracrine effects, extracellular vesicles (EVs) have been recently described as new players in cell-cell communication, as mediators of proteins, lipids, and genetic information. MSCs derived-EVs showed to be involved in a wide spread of processes, including angiogenesis, senescence, proliferation, and differentiation, beside strong immunomodulatory properties, and a key role in tissue homeostasis. The aim of this thesis is to characterize EVs released by MSCs to investigate their involvement as modulators of MSC paracrine effects. Exploiting this natural intercellular signaling mechanism could be beneficial to overcome some important limitations of cell therapies and, in this scenario, they could represent an efficient therapeutic vehicle for regenerative medicine.
title: XI. Agreement II / Ellipsis I – Kongruenz II / Ellipse I
title: Linguistic research in progress (Part XI, Winter Semester 1997/98)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
(401423) Mary Todd Andrews
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX
Creators: name: Chen, David J.
name: Liu, Feng
name: Jin, Jian
name: Dokholyan, Nikolay V.
name: Chen, Xian
name: Strahl, Brian D.
name: Ramachandran, Srinivas
name: Krajewski, Krzysztof
name: Zhu, Cheng
name: Wang, Li
name: Xie, Ling
name: Zhou, Li
name: Yan, Zhen
name: Lee, Yuan Yu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Regulatory mechanisms underlying γH2AX induction and the associated cell fate decision during DNA damage response (DDR) remain obscure. Here, we discover a bromodomain (BRD)-like module in DNA-PKcs (DNA-PKcs-BRD) that specifically recognizes H2AX acetyl-lysine 5 (K5ac) for sequential induction of γH2AX and concurrent cell fate decision(s). First, top-down mass spectrometry of radiation-phenotypic, full-length H2AX revealed a radiation-inducible, K5ac-dependent induction of γH2AX. Combined approaches of sequence-structure modeling/docking, site-directed mutagenesis, and biochemical experiments illustrated that through docking on H2AX K5ac, this non-canonical BRD determines not only the H2AX-targeting activity of DNA-PKcs but also the over-activation of DNA-PKcs in radioresistant tumor cells, whereas a Kac antagonist, JQ1, was able to bind to DNA-PKcs-BRD, leading to re-sensitization of tumor cells to radiation. This study elucidates the mechanism underlying the H2AX-dependent regulation of DNA-PKcs in ionizing radiation-induced, differential DDR, and derives an unconventional, non-catalytic domain target in DNA-PKs for overcoming resistance during cancer radiotherapy.
title: XII. Ellipsis in coordination (Ellipsis II) – Ellipse bei Koordination (Ellipse II)
title: Linguistic research in progress (Part XII, Winter Semester 1998/99)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
title: Pragmatic breast cancer risk estimation: experience from a high volume family history clinic.
Creators: name: Sharma, Nisha
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: Health policy and practice
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The first objective of this study was to understand the current landscape of risk assessments in a high volume family history clinic. The second objective of this analysis was to use a handful of established risk factors to evaluate feasibility of...
title: Clinical usefulness of multi-parameter spectral CT images in the diagnosis of pulmonary embolism
Creators: name: Tao, lei
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT-Angiography
subject: Acceptance testing
subject: Cardiac Assist Devices

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: 387/5000The increasing incidence of pulmonary embolism, in clinical just below the incidence of myocardial infarction and stroke, for clinical common acute cardiovascular disease, cardiovascular disease, one of the leading causes of death in...
(401418) Thomas Erskine
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides
Creators: name: Peterson, Randall T.
name: Mosier, Philip D.
name: Vardy, Eyal
name: Roth, Bryan L.
name: Stevens, Raymond C.
name: Kroeze, Wesley K.
name: Westkaemper, Richard B.
name: Stevens, Craig W.
name: Katritch, Vsevolod
name: Rennekamp, Andrew J.
name: Sassano, Maria F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: It has been suggested that the evolution of vertebrate opioid receptors (ORs) follow a vector of increased functionality. Here we test this idea comparing human and frog ORs. Interestingly, some of the most potent opioid peptides known have been isolated from amphibian skin secretions. Here we show that such peptides (dermorphin and deltorphin) are highly potent in the human receptors and inactive in frog ORs. The molecular basis for the insensitivity of the frog ORs to these peptides was studied using chimeras and molecular modeling. Interestingly, the insensitivity of the delta opioid receptor (DOR) to deltorphin was due to variation of a single amino acid– Trp7.35—which is a leucine in mammalian DORs. Notably, Trp7.35 is completely conserved in all known DOR sequences from lamprey, fish and amphibians. The deltorphin-insensitive phenotype was verified in fish. Our results provide a molecular explanation for the species selectivity of skin-derived opioid peptides.
title: Duane's retraction syndrome: MRI features
Creators: name: Mekouar, Younes
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Eyes
subject: MR
subject: Diagnostic procedure
subject: Imaging sequences
subject: Motility

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - Being able to describe the anatomy of the abducens nerve and its course. - Establish the value of MRI in the diagnosis of Duane retraction's syndrome (DRS) - Increase awareness of this unusual entity by highlighting the MRI features of the...
Xi Jinping and The Sino – Latin American Relations in The 21st Century: Facing The Beginning of A New Phase?
Creators: name: Van De Maele, Diego Leiva
Publisher: name: Journal of China and International Relations
Year: 2017

description: Sino-Latin American relations experienced an extraordinary "intensification process" throughout the first sixteen years of the 21st century. The present article analyses Sino-Latin American relations in the 21st century and proposes three major ideas. First, Sino-Latin American relations experienced an inflection point in 2001, which initiated an unprecedented process that intensified the relationship. Second, since the inflection point in 2001, the relationship established its foundations by transiting through an economic phase between 2001 and 2008, and a soft power phase between 2008 and 2013. Finally, since Xi Jinping took office in 2013, Sino-Latin American relations might be entering a comprehensive new phase that goes beyond trade and soft power, including the political and military-strategic dimensions. The article will be structured as follows: 1) it provides an overview of Sino-Latin American relations in the 21st century; 2) then it describes how the foundations of the relationship were established in its first two phases; 3) finally, this article provides a proposal of a new phase of Sino-Latin American relations since 2013.
description: Journal of China and International Relations, Vol 5 No 1 (2017)
title: IV. Noun Group Problems III – Probleme der Nominalgruppe III
title: Linguistic research in progress (Part IV, Summer Semester 1993)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
Long-Term Consequences of Early-in-Life Genetic and Pharmacological Interventions In Down Syndrome Mice
Creators: name: ZIOGAS, ILIAS
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Down syndrome (DS) is the leading cause of genetically-defined intellectual disability. Additionally, DS individuals often present with increased susceptibility to epileptic seizures and hyperactivity. Recently, several studies identified altered GABAergic activity through chloride-permeable GABAA receptors as one of the main contributors to impaired cognitive performance in the Ts65Dn mouse model of DS. Data from adult Ts65Dn mice and DS individuals showed an increased expression of the chloride importer NKCC1. As a result, intracellular chloride concentration is higher in Ts65Dn mice and GABAergic responses are depolarizing (vs hyperpolarizing and inhibitory). Accordingly, treatment with the FDA-approved diuretic and NKCC1 inhibitor bumetanide during adulthood rescues inhibitory GABAergic transmission and cognitive deficits in DS mice, although the beneficial effect of the treatment is rapidly lost upon drug withdrawal. However, hyperactivity and susceptibility to seizures are not rescued by bumetanide treatment in adulthood. Here, we investigated the long-term effects of early-in-life genetic and pharmacological interventions targeting NKCC1 by neuron-specific AAV9-mediated NKCC1 knockdown and bumetanide treatment during the first 2 weeks of development, respectively. We found a rescue in long-term memory in two different memory tasks in adult Ts65Dn animals after both interventions. Additionally, early NKCC1 downregulation rescued short-term memory, susceptibility to seizures and hyperactivity phenotype in Ts65Dn mice in adulthood. Notably, both early-in-life genetic and pharmacological interventions rescued the increased GABA-mediated spiking events in acute brain slices from adult trisomic animals. Finally, since bumetanide treatment of human infants can lead to deafness, we assessed ototoxicity in adult WT and Ts65Dn mice treated early in development and found no significant deficits in acoustic startle-response. Our results suggest that time-specific interventions possibly impacting on the trajectories of the developing brain could rescue cognitive performance and deficits that are not rescued by treatment in adulthood, avoiding the adverse diuretic effects of the required chronic adult treatment with bumetanide.
Planar channeling and quasichanneling oscillations in a bent crystal
Creators: name: Sytov, A. I.
name: Guidi, V.
name: Tikhomirov, V. V.
name: Bagli, E.
name: Bandiera, L.
name: Germogli, G.
name: Mazzolari, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Particles passing through a crystal under planar channeling experience transverse oscillations in their motion. As channeled particles approach the atomic planes of a crystal, they are likely to be dechanneled. This effect was used in ion-beam analysis with MeV energy. We studied this effect in a bent crystal for positive and negative particles within a wide range of energies in sight of application of such crystals at accelerators. We found the conditions for the appearance or not of channeling oscillations. Indeed a new kind of oscillations, strictly related to the motion of over-barrier particles, i.e. quasichanneling particles, has been predicted. Such oscillations, named planar quasichanneling oscillations, possess a different nature than channeling oscillations. Through computer simulation, we studied this effect and provided a theoretical interpretation for them. We show that channeling oscillations can be observed only for positive particles while quasichanneling oscillations can exist for particles with either sign. The conditions for experimental observation of channeling and quasichanneling oscillations at existing accelerators with available crystal has been found and optimized.
description: 25 pages, 11 figures
Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity
Creators: name: Mani, Sridhar
name: Redinbo, Matthew R.
name: Figueroa, Esteban
name: Ingle, James D.
name: Pollet, Rebecca M.
name: Venkatesh, Madhu Kumar
name: Cohen, Rachel D.
name: Zamboni, William C.
name: Jin, Jian
name: Guthrie, Leah
name: Robinson, Sara J.
name: Kelly, Libusha
name: Roberts, Adam B.
name: Wallace, Bret D.
name: O'Neal, Sara K.
name: Pellock, Samuel J.
name: Pepe-Ranney, Charles
name: McShane, Sarah R.
name: Frye, Stephen V.
name: Dollinger, Makani
name: Biernat, Kristen A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SummaryThe selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-induced gastrointestinal toxicity in mice, including the damage caused by the widely used anticancer drug irinotecan. Here, we report crystal structures of representative β-glucuronidases from the Firmicutes Streptococcus agalactiae and Clostridium perfringens and the Proteobacterium Escherichia coli, and the characterization of a β-glucuronidase from the Bacteroidetes Bacteroides fragilis. While largely similar in structure, these enzymes exhibit marked differences in catalytic properties and propensities for inhibition, indicating that the microbiome maintains functional diversity in orthologous enzymes. Small changes in the structure of designed inhibitors can induce significant conformational changes in the β-glucuronidase active site. Finally, we establish that β-glucuronidase inhibition does not alter the serum pharmacokinetics of irinotecan or its metabolites in mice. Together, the data presented advance our in vitro and in vivo understanding of the microbial β-glucuronidases, a promising new set of targets for controlling drug-induced gastrointestinal toxicity.
Marginal evidence for cosmic acceleration from Type Ia supernovae
Creators: name: Nielsen, Jeppe Trøst
name: Guffanti, Alberto
name: Sarkar, Subir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The "standard" model of cosmology is founded on the basis that the expansion rate of the universe is accelerating at present --- as was inferred originally from the Hubble diagram of Type Ia supernovae. There exists now a much bigger database of supernovae so we can perform rigorous statistical tests to check whether these "standardisable candles" indeed indicate cosmic acceleration. Taking account of the empirical procedure by which corrections are made to their absolute magnitudes to allow for the varying shape of the light curve and extinction by dust, we find, rather surprisingly, that the data are still quite consistent with a constant rate of expansion.
description: 7 pages, 5 figures; Version submitted for publication on 21 July 2016; Analysis code and data used available on: http://dx.doi.org/10.5281/zenodo.34487
Inorganic/Organic Hybrid Silica Nanoparticles as a Nitric Oxide Delivery Scaffold
Creators: name: Shin, Jae Ho
name: Schoenfisch, Mark H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The preparation and characterization of nitric oxide (NO)-releasing silica particles formed following the synthesis of N-diazeniumdiolate-modified aminoalkoxysilanes are reported. Briefly, an aminoalkoxysilane solution was prepared by dissolving an appropriate amount of aminoalkoxysilane in a mixture of ethanol, methanol, and sodium methoxide (NaOMe) base. The silane solution was reacted with NO (5 atm) to form N-diazeniumdiolate NO donor moieties on the amino-alkoxysilanes. Tetraethoxy- or tetramethoxysilane (TEOS or TMOS) was then mixed with different ratios of N-diazeniumdiolate-modified aminoalkoxysilane (10 – 75 mol%, balance TEOS or TMOS). Finally, the silane mixture was added into ethanol in the presence of an ammonia catalyst to form NO donor silica nanoparticles via a sol–gel process. This synthetic approach allows for the preparation of NO delivery silica scaffolds with remarkably improved NO storage and release properties, surpassing all macromolecular NO donor systems reported to date with respect to NO payload (11.26μmol·mg−1), maximum NO release amount (357000 ppb·mg−1), NO release half-life (253 min), and NO release duration (101 h). The N-diazeniumdiolate-modified silane monomers and the resulting silica nanoparticles were characterized by 29Si nuclear magnetic resonance (NMR) spectroscopy, UV-visible spectroscopy, chemiluminescence, atomic force microscopy (AFM), gas adsorption-desorption isotherms, and elemental analysis.
title: VII. Relative clauses II – Relativsätze II
title: Linguistic research in progress (Part VII, Winter Semester 1995/96)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
Defective FAS-Mediated Apoptosis and Immune Dysregulation in Gaucher Disease
Creators: name: MADEO, ANNALISA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Introduzione: La malattia di Gaucher (GD) � la pi� frequente patologia da accumulo lisosomiale, causata dalla ridotta attivit� dell?enzima ?-glucosidasi acida, che determina un progressivo accumulo di glucosilceramide nelle cellule del sistema reticolo-endoteliale. L?epatosplenomegalia e la citopenia sono le manifestazioni cliniche pi� comuni, ma i pazienti affetti presentano anche una disregolazione immunologica con alterazione del pattern citochinico e chemochinico e alterazioni funzionali a carico non solo dei monociti-macrofagi, ma anche di linfociti B, T e natural killer (NK). Inoltre, le manifestazioni cliniche sono parzialmente sovrapponibili a quelle della sindrome linfo-proliferativa autoimmune (ALPS) o di altri disordini immunologici ALPS-like. L?obiettivo principale di questo lavoro � l?identificazione di possibili alterazioni immunologiche ALPS-like e di un eventuale difetto di apoptosi nei pazienti con malattia di Gaucher. Pazienti e metodi: Nello studio sono stati arruolati i pazienti con GD valutati presso la UOSD Malattie Rare dell?IRCCS Giannina Gaslini in un periodo di 18 mesi. Per ciascun paziente � stato eseguito uno studio delle sottopopolazioni linfocitarie e dei parametri immunofenotipici e sierologici caratteristicamente alterati nell?ALPS (linfociti T doppi negativi (DNT), B220+DNT, CD27+, T-reg/HLA-DR ratio, IL-10, IL-18, vitamina B12) e uno screening autoanticorpale. Nei pazienti con alterazione significativa di questi parametri � stato eseguito anche uno studio in vitro dell?apoptosi FAS-mediata e dell?attivazione delle caspasi. Risultati: Sono stati inclusi nello studio 41 pazienti, di cui 33 in terapia e 8 non trattati. Un incremento dei linfociti DNT e B220+DNA � stato riscontrato, rispettivamente, in 9/41 (21%) e 7/41 (17%) pazienti. 10/41 (24%) presentavano alterazioni immunologiche suggestive di ALPS, pi� frequenti nei pazienti non trattati (p=0,003) e nei pazienti con esordio precoce di GD (p=0,01). L?apoptosi indotta da FAS e l?attivazione delle caspasi sono risultate deficitarie in 7 di questi 10 pazienti. Conclusioni: Lo studio dimostra che i pazienti con GD possono presentare delle alterazioni immunologiche ALPS-like e un deficit dell?apoptosi FAS-mediata, pi� frequenti nei pazienti non trattati e nei pazienti con esordio precoce di malattia. La malattia di Gaucher pertanto dovrebbe essere considerata in diagnosi differenziale nei pazienti con un fenotipo ALPS-like.
title: Cystic lung disease: a differential
Creators: name: Van Snick, Elyn
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Respiratory system
subject: Thorax
subject: CT
subject: Education
subject: Cysts

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: This poster aims to provide a short and comprehensible overview of the differential of cystic lung disease. Cystic lung diseases are rare and most radiologists don't encounter them often in daily practice. This poster aims to provide a short...
Stöber Synthesis of Nitric Oxide-Releasing S-Nitrosothiol-Modified Silica Particles
Creators: name: Nugent, Julia L.
name: Schoenfisch, Mark H.
name: Riccio, Daniel A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We report the synthesis of S-nitrosothiol-modified silica particles capable of nitric oxide (NO) release. The thiol precursor modification to form S–nitrosothiol NO donors was introduced into the silica network via co-condensation of mercaptosilane and alkoxysilane precursors. Both the concentrations of reactants (i.e., water, ammonia, and silane) and the silane feed rate into the reaction proved important in the yield of monodisperse, spherical particles with tunable diameters ranging from 241–718 nm. Subsequent nitrosation resulted in NO storage approaching ~4.40 μmol NO mg−1, as determined by total NO release. Behaving similar to low molecular weight S-nitrosothiol NO donors, the NO release from the macromolecular silica vehicles was influenced by light, temperature, and metal ions.
Application of Uncertainty Quantification techniques to CFD simulation of twin entry radial turbines
Creators: name: OTTONELLO, ANDREA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: L'argomento principale della tesi � l'applicazione delle tecniche di quantificazione dell'incertezza (UQ) alla simulazione numerica (CFD) di turbine radiali twin entry impiegate nella turbosovralimentazione automobilistica. Lo studio approfondito di questo tipo di turbomacchine � affrontato nel capitolo 3, finalizzato alla comprensione dei principali parametri che caratterizzano e influenzano le prestazioni fluidodinamiche delle turbine twin scroll. Il capitolo 4 tratta di una piattaforma per l'analisi UQ sviluppata internamente tramite il set di strumenti open source ?Dakota?. La piattaforma � stata testata dapprima su un caso di interesse industriale, ovvero un ugello de Laval supersonico (capitolo 5); l'analisi ha evidenziato l'utilizzo pratico delle tecniche di quantificazione dell'incertezza nella previsione delle prestazioni di un ugello affetto da condizioni di fuori progetto con complessit� fluidodinamica dovuta alla forte non linearit�. L'esperienza maturata con l'approccio UQ ha agevolato l'identificazione di metodi idonei per applicare la propagazione dell?incertezza alla simulazione CFD di turbine radiali twin scroll (capitolo 6). In tal caso sono state studiate e messe in pratica diverse tecniche di quantificazione dell'incertezza al fine di acquisire un'esperienza approfondita sull?attuale stato dell'arte. Il confronto dei risultati ottenuti dai diversi approcci e la discussione dei pro e dei contro relativi a ciascuna tecnica hanno portato a conclusioni interessanti, che vengono proposte come linee guida per future applicazioni di quantificazione dell?incertezza alla simulazione CFD delle turbine radiali. L'integrazione di modelli e metodologie UQ, oggi utilizzati solo da alcuni centri di ricerca accademica, con solutori CFD commerciali consolidati ha permesso di raggiungere l'obiettivo finale della tesi di dottorato: dimostrare all'industria l'elevato potenziale delle tecniche UQ nel migliorare, attraverso distribuzioni di probabilit�, la previsione delle prestazioni relative ad un componente soggetto a diverse fonti di incertezza. Lo scopo dell?attivit� di ricerca consiste pertanto nel fornire ai progettisti dati prestazionali associati a margini di incertezza che consentano di correlare meglio simulazione e applicazione reale. Per accordi di riservatezza, i parametri geometrici relativi alla turbina twin entry in oggetto sono forniti adimensionali, i dati sensibili sugli assi dei grafici sono stati omessi e nelle figure si � reso necessario eliminare le legende dei contours ed ogni eventuale riferimento dimensionale.
Additional file 1 of Cancer in Moroccan elderly: the first multicenter transverse study exploring the sociodemographic characteristics, clinical profile and quality of life of elderly Moroccan cancer patients
Creators: name: Amzerin, Mounia
name: Layachi, Mohamed
name: Bazine, Aziz
name: Aassab, Rachid
name: Arifi, Samia
name: Zineb Benbrahim
name: Khmamouche, Mohamed Reda
name: Kairouani, Mouna
name: Raiss, Hanan
name: Majid, Noura
name: Saloua Ouaouch
name: Ichou, Mohammed
name: Afqir, Said
name: Nawfal Mellas
name: Fetohi, Mohamed
name: Razine, Rachid
name: Errihani, Hassan
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
(401414) Margaret McLeigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors
Creators: name: Wang, Huanchen
name: González-García, Coral
name: Campillo, Nuria E.
name: Hernández, Javier
name: Cuenca, Jimena
name: Ke, Hengming
name: Pérez, Concepción
name: Luque, F. Javier
name: Gil, Carmen
name: Gelpí, José Luis
name: Ballester, Sara
name: Martínez, Ana
name: Huertas, Oscar
name: Castaño, Tania
name: Pérez-Castillo, Ana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: PDE7 inhibitors regulate pro-inflammatory and immune T-cell functions, and are a potentially novel class of drugs especially useful in the treatment of a wide variety of immune and inflammatory disorders. Starting from our lead family of thioxoquinazolines, we designed, synthesized, and characterized a novel series of thioxoquinazoline derivatives. Many of these compounds showed inhibitory potencies at sub-micromolar levels against the catalytic domain of PDE7A1 and at the micromolar level against PDE4D2. Cell-based studies showed that these compounds not only increased intracellular cAMP levels, but also had interesting anti-inflammatory properties within a therapeutic window. The in silico data predict that these compounds are capable of the crossing the blood–brain barrier. The X-ray crystal structure of the PDE7A1 catalytic domain in complex with compound 15 at a resolution of 2.4 Å demonstrated that hydrophobic interactions at the active site pocket are a key feature. This structure, together with molecular modeling, provides insight into the selectivity of the PDE inhibitors and a template for the discovery of new PDE7 or PDE7/PDE4 dual inhibitors.
title: Pituitary Apoplexy: radiological findings
Creators: name: Bellitti, Roberto
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Imaging sequences
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To recognize pituitary apoplexy (PA) on Computed Tomography (CT) and Magnetic Resonance Imaging...
HTS and Rational Drug Design [RDD] to Generate a Class of 5-HT2C-Selective Ligands for Possible Use in Schizophrenia
Creators: name: Kozikowski, Alan P.
name: Cho, Sung Jin
name: Allen, John A.
name: Jensen, Niels H.
name: Roth, Bryan L.
name: Svennebring, Andreas M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: (Chemical Equation Presented) Treating neurological conditions: Optimization of a previously identified lead 5-HT2C agonist (left) led to the discovery of a highly selective 5-HT2C agonist (right). Importantly, this compound is a 5-HT2B receptor antagonist. Because of its selective 5-HT2C receptor activity, the compound was further evaluated in the phencyclidine model of disrupted prepulse inhibition, and found to exhibit normalizing effects comparable to those shown by the 5-HT 2C agonist vabicaserin, a drug currently in phase II clinical studies for schizophrenia.
(401416) William Wallace
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Modelos contempor�neos de autoridad. Elementos para un an�lisis de los problemas, conceptos y modelos de discurso sobre la autoridad desde la filosof�a del derecho
Creators: name: RABANOS, JULIETA AGUSTINA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Il problema dell?autorit� � centrale per la filosofia del diritto. Tre domande generali possono essere considerate: Cos?� ?autorit�?? (domanda concettuale); Dovrebbe essere l??autorit�? obbedita? (domanda normativa); � dato un qualche rapporto (necessario o contingente) tra queste due domande? Dalla prospettiva della filosofia analitica, il presente lavoro persegue un triplice obiettivo. Primo, offrire una chiarificazione del dibattito contemporaneo sull'autorit�, giacch�, alle volte, non � chiaro su cosa sia il disaccordo (ovvero se ce n'� alcuno). Secondo, evidenziare che ci sono schemi comuni su come l?autorit� possa essere trattata, rappresentabili come ?modelli di discorsi? generali, e cos� analizzati e comparati. A questo scopo, verranno offerti tre esempi di possibili modelli di discorso: il modello raziano (rappresentato da Joseph Raz), il modello normativista (rappresentato da John Finnis), e il modello empirista (rappresentato da Karl Olivecrona). Infine, porre la domanda su quale sia il ?modello di discorso? pi� adeguato a trattare l?autorit�, se sosteniamo un approccio filosofico neutrale, orientato alla descrizione e meno dipendenti da assunzioni di varia natura. Nel presente lavoro si argomenter� a favore del modello empiristico, tra i tre modelli analizzati, come quello pi� adeguato.
title: I feel a lump in my neck: The role of ultrasonography for the evaluation of cervical lymph nodes in children
Creators: name: Teixeira, Ana Teresa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: Lymph nodes
subject: Paediatric
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Diagnostic procedure
subject: Infection
subject: Lymphoma
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the normal cervical lymph nodes anatomy and its ultrasound (US) appearance. To highlight the importance of US evaluation and follow-up of lymphadenopathies. To review the spectrum of pathologies that develop head and neck...
A chemical tool for chemiprecipitation of the lysine methyltransferase, G9a, in vitro and in vivo
Creators: name: Simon, Jeremy M.
name: Li, Fengling
name: Davis, Ian J.
name: Jin, Jian
name: Barsyte-Lovejoy, Dalia
name: Liu, Feng
name: Konze, Kyle D.
name: Vedadi, Masoud
name: Pattenden, Samantha G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Here we report the design, synthesis, and biochemical characterization of a new chemical tool, UNC0965. UNC0965 is a biotinylated version of our previously reported G9a chemical probe, UNC0638. Importantly, UNC0965 maintains high in vitro potency and is cell penetrant. The biotinylated tag of UNC0965 enables chemiprecipitation of G9a from whole cell lysates. Further, the cell penetrance of UNC0965 allowed us to explore the localization of G9a on chromatin both in vitro and in vivo.
title: VIII. Valence and Government I – Valenz und Rektion I
title: Linguistic research in progress (Part VIII, Summer Semester 1996)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
Aspetti fisiologici e fisiopatologici dell?integrazione sensorimotoria
Creators: name: CRISAFULLI, OSCAR
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: My PhD program was mainly focused on the physiological and pathophysiological characteristics of sensorimotor integration. As part of this activity, I studied particular aspects of this topic in different populations of subjects: healthy young adults, visually impaired subjects, subjects suffering from Parkinson's disease and subjects suffering from cervical dystonia. Sensorimotor integration is a complex process that involves numerous central and peripheral nervous structures and is the basis of fundamental functions including the perception of the body in space and maintaining balance both in static and dynamic conditions. In the various studies published during the PhD program, I was able to investigate the stabilizing effects on the equilibrium of the haptic afference provided indirectly in the healthy young adult subject. Subsequently, we studied the effect of the stabilization given by the indirect haptic afference in blind and partially sighted subjects, then comparing the results with those obtained by providing the subjects with a direct haptic afference. Still on healthy young adult subjects, we investigated the effects of unilateral proprioceptive stimulation of the axial muscles on the podokinetic reflex, elicited by stepping in place on a rotating platform. In subjects suffering from Parkinson's disease, we evaluated the efficiency of the postural stabilization mechanisms necessary to counteract the perturbations induced by the motor resonance effect. In subjects suffering from cervical dystonia, we studied the characteristics of proprioceptive accuracy in the dystonic body segment and in a body segment not affected by the disease. In addition, a further study on a population of subjects suffering from cervical dystonia is currently under review, this time concerning the balance and kinematic characteristics of gait. The purpose of this thesis is to summarize the scientific activity of my PhD program.
Characterization of the Inner Knot of the Crab: The Site of the Gamma-ray Flares?
Creators: name: Rudy, A.
name: Horns, D.
name: DeLuca, A.
name: Kolodziejczak, J.
name: Tennant, A.
name: Yuan, Y.
name: Buehler, R.
name: Arons, J.
name: Blandford, R.
name: Caraveo, P.
name: Costa, E.
name: Funk, S.
name: Hays, E.
name: Lobanov, A.
name: Max, C.
name: Mayer, M.
name: Mignani, R.
name: O'Dell, S. L.
name: Romani, R.
name: Tavani, M.
name: Weisskopf, M. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: One of the most intriguing results from the gamma-ray instruments in orbit has been the detection of powerful flares from the Crab Nebula. These flares challenge our understanding of pulsar wind nebulae and models for particle acceleration. We report on the portion of a multiwavelength campaign using Keck, HST, and Chandra concentrating on a small emitting region, the Crab's inner knot, located a fraction of an arcsecond from the pulsar. We find that the knot's radial size, tangential size, peak flux, and the ratio of the flux to that of the pulsar are correlated with the projected distance of the knot from the pulsar. A new approach, using singular value decomposition for analyzing time series of images, was introduced yielding results consistent with the more traditional methods while some uncertainties were substantially reduced. We exploit the characterization of the knot to discuss constraints on standard shock-model parameters that may be inferred from our observations assuming the inner knot lies near to the shocked surface. These include inferences as to wind magnetization, shock shape parameters such as incident angle and poloidal radius of curvature, as well as the IR/optical emitting particle enthalpy fraction. We find that while the standard shock model gives good agreement with observation in many respects, there remain two puzzles: (a) The observed angular size of the knot relative to the pulsar--knot separation is much smaller than expected; (b) The variable, yet high degree of polarization reported is difficult to reconcile with a highly relativistic downstream flow.
description: 46 pages, 14 figures, submitted to the Astrophysical Journal
(401417) Jean Craigie Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Popliteal Vein Entrapment Syndrome
Creators: name: Borzì, Santo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Vascular
subject: Ultrasound-Colour Doppler
subject: Arterial access
subject: Varices

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Vascular compression syndromes include a group of rare alterations due to the extrinsic compression of vascular structures determined by surrounding structures. This spectrum of abnormalities can be related to congenital anomalies or acquired. These...
Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6-Diarylpyridinamines as a Novel Class of HIV-1 NNRTIS
Creators: name: Jiang, Shibo
name: Huang, Li
name: Chen, Chin Ho
name: Lee, Kuo Hsiung
name: Liu, Na
name: Xie, Lan
name: Wu, Zhi Yuan
name: Morris-Natschke, Susan L.
name: Qin, Bingjie
name: Qian, Keduo
name: Yu, Fei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Nineteen new halogenated diarylpyridinamine (DAPA) analogues (6a-n and 8a-e) modified on the phenoxy C-ring were synthesized and evaluated for anti-HIV activity and certain drug-like properties. Ten compounds showed high anti-HIV activity (EC50 < 10 nM). Particularly, (E)-6-(2”-bromo-4”-cyanovinyl-6“-methoxy)phenoxy-N2-(4′-cyanophenyl)pyridin-2,3-diamine (8c) displayed low nanomolar antiviral potency (3–7 nM) against wild-type and resistant viral strains with E138K or K101E mutation, associated with resistance to rilvipirine (1b). Compound 8c exhibited much lower resistance fold changes (RFC 1.1–2.1) than 1b (RFC 11.8–13.0). Compound 8c also exhibited better metabolic stability (in vitro half-life) than 1b in human liver microsomes (HLM), possessed low lipophilicity (clog D: 3.29; measured log P: 3.31), and had desirable lipophilic efficiency indices (LE > 0.3, LLE >5, LELP <10). With balanced potency and drug-like properties, 8c merits further development as an anti-HIV drug candidate.
title: Acquired Portal Vein Conditions in CT – All You Need to Know
Creators: name: Rodrigues, Maria Inês
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Veins / Vena cava
subject: CT
subject: Computer Applications-Detection, diagnosis
subject: Cirrhosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The portal venous system is a unique circulatory system, draining blood from the gastrointestinal tract (with exception of the lower rectum), spleen, pancreas, and gallbladder to the liver. It contributes to nearly 70% of its blood flow, with the...