cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dichogaster (Diplothecodrilus) pauliani Csuzdi & Zicsi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Dichogaster
Dichogaster pauliani

description: Dichogaster (Diplothecodrilus) pauliani Csuzdi & Zicsi, 1989
Dichogaster pauliani Csuzdi & Zicsi, 1989 Mitt. Hamb. Zool. Mus. Inst. 86: 141.
Dichogaster (Diplothecodrilus) pauliani: Csuzdi 1995 Ann. Naturhist. Mus. Wien 97B: 114.
Dichogaster (Diplothecodrilus) pauliani: Csuzdi 1996 Mitt. Hamb. Zool. Mus. Inst. 93: 15.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 15, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Genomics and transcriptomics of the greater duckweed, Spirodela polyrhiza, a model for aquatic biology
Creators: name: Wang, Wenqin
Publisher: name: No Publisher Supplied
Year: 2014

description: My thesis provides the first whole genome analysis of an aquatic plant, Spirodela polyrhiza and a reference genome for a new order among the monocotelydonous angiosperms. The Lemnoideae belong to the order of the Alismatales and are commonly known as duckweeds, the smallest, fastest growing, and simplest of aquatic plants, thus telling them apart is not a trivial task. Whereas a simple and accessible protocol has been established for land plants by the Consortium for the Barcode of Life with seven universal DNA barcoding markers, we found that atpF-atpH noncoding spacer is the most promising marker for duckweed species-level identification. Furthermore, our assembly and annotation of the Spirodela chloroplast and mitochondrial genomes open an opportunity of population-level classification.   A key to our understanding of the evolution of a species and its potential use is the gene content of the organism. Therefore, we sequenced Spirodela polyrhiza &498 that has one of the smallest genomes with 158 Mb within this subfamily of species. The genome contains 19,623 predicted protein-coding genes, sharing a total of 8,255 common gene families with Arabidopsis, tomato, banana, and rice despite a significantly reduced gene number. Reduced gene families and missing genes reflect changes consistent with its compact and reduced morphogenesis or forever-young life style, aquatic suspension, and suppression of juvenile-to-adult transition.  Spirodela exhibits a remarkable phenotypic plasticity to adapt to cold weather in winter. We identified and functionally annotated 362 differentially expressed genes, which open a major step towards understanding the molecular network underlying vegetative frond dormancy. Moreover, the expression data for lipid and starch biosynthesis together with the turion-specific transcriptional genes from our RNA-Seq data could be ideal targets to develop duckweeds into oil crops.  Thanks to its unique and fascinating biology, applications of duckweed in water remediation and as a renewable energy source are predicted to have a bright future. The genome sequence of Spirodela provides the first step to identify, understand, and improve relevant traits for specific target applications.
Local planning for continuous Markov decision processes
Creators: name: Weinstein, Ariel
Publisher: name: No Publisher Supplied
Year: 2014

description: In this dissertation, algorithms that create plans to maximize a numeric reward over time are discussed.  A general formulation of this problem is in terms of reinforcement learning (RL), which has traditionally been restricted to small discrete domains.  Here, we are concerned instead with domains that violate this assumption, as we assume domains are both continuous and high dimensional.  Problems of swimming, riding a bicycle, and walking are concrete examples of domains satisfying these assumptions, and simulations of these problems are tackled here.  To perform planning in continuous domains, it has become common practice to use discrete planners after uniformly discretizing dimensions of the problem, leading to an exponential growth in problem size as dimension increases.  Furthermore, traditional methods develop a policy for the entire domain simultaneously, but have at best polynomial planning costs in the size of the problem, which (as mentioned) grows exponentially with respect to dimension when uniform discretization is performed.  To sidestep this problem, I propose a twofold approach of: using algorithms designed to function natively in continuous domains, and performing planning locally.  By developing planners that function natively in continuous domains, difficult decisions related to how coarsely to discretize the problem are avoided, which allows for more flexible and efficient algorithms that more efficiently allocate and use samples of transitions and rewards.  By focusing on local planning algorithms, it is possible to somewhat sidestep the curse of dimensionality, as planning costs are dependent on planning horizon as opposed to domain size.  The properties of some local continuous planners are discussed from a theoretical perspective.   Empirically, the superiority of continuous planners is demonstrated with respect to their discrete counterparts.  Both theoretically and empirically, it is shown that algorithms designed to operate natively in continuous domains are simpler to use while providing higher quality results, more efficiently.
Tocks Island Regional Advisory Council first annual report
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1967

description: This annual report is the first for the Tocks Island Regional Advisory Council (TIRAC). It includes an overview of TIRAC: what and why?; a historical note; TIRAC in brief; report of activities; regional concerns; informational activities and services; coordinating activities; and a statement of income and expenditures.
Tocks Island Regional Advisory Council third annual report 1968
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1969

description: This is the third annual report for the Tocks Island Regional Advisory Council (TIRAC). It includes a report of the committee's activities; discussion of the following: regional environmental protection system, the regional planning program, citizens information and involvement; initiation of regional action programs; financial statements; a listing of TIRAC's advisory groups and special committees.
Centropomus unionensis Bocourt 1868
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Centropomidae
Centropomus
Centropomus unionensis

description: Centropomus unionensis Bocourt 1868. Humpback Snook, Union Snook; Róbalo Chato, Róbalo Mano de Piedra, Róbalo Serrano
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from the mouth of the Gulf of California, Mexico, to northen Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN and Ni (Pacific); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown.
Literature: Robertson & Allen (2015: 1090; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 42; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 41, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Dichogaster (Diplothecodrilus) sorosi Csuzdi & Zicsi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Dichogaster
Dichogaster sorosi

description: Dichogaster (Diplothecodrilus) sorosi Csuzdi & Zicsi, 1989
Dichogaster sorosi Csuzdi & Zicsi, 1989 Mitt. Hamb. Zool. Mus. Inst. 86: 142.
Dichogaster (Diplothecodrilus) sorosi: Csuzdi 1995 Ann. Naturhist. Mus. Wien 97B: 111.
Dichogaster (Diplothecodrilus) sorosi: Csuzdi 1996b Mitt. Hamb. Zool. Mus. Inst. 93: 15.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 15, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
The construction of an anti-feminist pedagogy in an abstinence-only-until-marriage curriculum
Creators: name: Wojtowicz, Kaitlyn
Publisher: name: No Publisher Supplied
Year: 2014

description: Sexuality, sexuality education, and teaching about sexuality are inherently feminist topics. There is a way in which to teach sexuality education that deconstructs dominant power structures, empowers students, and that has life-long positive impacts upon the young people in the classroom. In short, utilizing a feminist pedagogy is extremely important when teaching about sex, sexuality, and sexual health. Recently, the U.S. Department of Health and Human Services (HHS) placed an abstinence-only-until-marriage curriculum, Heritage Keepers Abstinence Education, on a list of endorsed curriculum with evidence-based comprehensive or abstinence-plus sexuality education curriculum. Much has been written about the false information in Heritage Keepers Abstinence Education. However, less has been written about the gendered implications of this curriculum and what a curriculum such as this means in the context of feminist pedagogy. My project will not just focus on a gendered reading of Heritage Keepers Abstinence Education using an intersectional approach, but will also examine the ways in a curriculum such as Heritage Keepers Abstinence Education works against feminist pedagogies in dangerous ways. The theories I believe will be most pertinent to my project and will inform and frame this paper include Nel Nodding’s ethic of care, as well as, bell hooks’ theories on feminist pedagogy, engaged pedagogy, and critical thinking. Through a review of the popular literature around Heritage Keepers Abstinence Education, the Heritage Keepers Abstinence Education curriculum itself, and theoretical texts I hope to achieve a more nuanced critique of this curriculum and its implications for the students it is taught to when it comes to important identity categories, with special regard to gender, but at once not leaving out race, class and sexual orientation, as well as in the context of education and the impact that a curriculum such as this can have on the learning outcomes and future learning of students when it comes to sexuality.
Dichogaster (Diplothecodrilus) thibaudi Csuzdi & Zicsi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Dichogaster
Dichogaster thibaudi

description: Dichogaster (Diplothecodrilus) thibaudi Csuzdi & Zicsi, 1989
Dichogaster thibaudi Csuzdi & Zicsi 1989 Mitt. Hamb. Zool. Mus. Inst. 86: 144.
Dichogaster (Diplothecodrilus) thibaudi: Csuzdi 1995 Ann. Naturhist. Mus. Wien 97B: 114.
Dichogaster (Diplothecodrilus) thibaudi: Csuzdi 1996b Mitt. Hamb. Zool. Mus. Inst. 93: 15.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Centropomus viridis Lockington 1877
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Centropomidae
Centropomus
Centropomus viridis

description: Centropomus viridis Lockington 1877. White Snook; Róbalo Blanco, Róbalo Plateado
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from Baja California, Mexico, to northern Peru, including the Galapagos islands; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN (Pacific); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2020), population trend unknown. Literature: Robertson & Allen (2015: 1091; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 42; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 41, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Eutrigaster (Graffiona) eiseni Csuzdi & Zicsi 1991, comb. nov.
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Eutrigaster
Eutrigaster eiseni

description: Eutrigaster (Graffiona) eiseni Csuzdi & Zicsi, 1991 comb. nov.
Eutrigaster (Graffia) eiseni Csuzdi & Zicsi, 1991 Acta Zool. Hung. 37 (3–4): 188.
Remarks. The subgenus Eutrigaster (Graffia) Csuzdi & Zicsi, 1991 proved to be homonymous and was replaced by Eutrigaster (Graffiona) Csuzdi, 2014 (Csuzdi 2014). However, in the list of the included species E. (Graffiona) eiseni was left out.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Examination of cardiovascular outcomes in patients admitted for acute myocardial infarction within United States community hospitals
Creators: name: Woodruff, Kimberly Beth
Publisher: name: No Publisher Supplied
Year: 2014

description: Objective:  The objective of this dissertation was to examine cardiovascular (CV) outcomes in patients admitted for acute myocardial infarction (AMI) within United States (U.S.) community hospitals, focusing on three areas:  impact of primary payer type among patients admitted for ST-segment elevation myocardial infarction (STEMI); effect of weekday vs. weekend admissions among STEMI hospitalizations; examination of trends in AMI type over a 10-year timeframe.  Methods:  We conducted retrospective cohort studies using hospital discharge data from the Nationwide Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.  Chapters 1 and 2 included the years 2005, 2008, and 2010, while Chapter 3 included the years 2000, 2005, and 2010.  Results:  Chapter 1 results indicated that among patients <65, those with private insurance as the primary payer type were significantly less likely to experience in-hospital mortality vs. patients with other primary forms of payment.  In Chapter 2, results suggested that odds of in-hospital mortality in the overall cohort for weekday vs. weekend admissions depended on patient’s race in 2005 and 2008, with no significant difference observed in 2010; however those with comorbid diabetes had more favorable outcomes when admitted on a weekday across all years studied.  In Chapter 3, we observed an approximately 54% decrease in STEMI, and 10% decrease in NSTEMI hospitalizations over the timeframe studied; however the odds of in-hospital mortality remained significantly higher for STEMI vs. NSTEMI admissions over the decade.  Conclusions:  Results of this research suggest the following: 1) Patients <65 who have private health insurance experience lower odds of in-hospital mortality vs. those with other primary forms of payment; 2)  In recent years, admission day does not appear to impact in-hospital mortality, except in those with comorbid diabetes; and 3)  The clinical presentation of AMI within U.S. community hospitals has changed over the past decade; however STEMI admissions are still associated with increased odds of in-hospital mortality vs. NSTEMI admissions.
Oncolytic y-herpesvirus for induction of anti-tumor immunity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tumor-selective replicating lytic viruses are an emerging approach in the next generation of cancer therapy. In addition to the ability of viruses to preferentially lyse and kill cancer cells, viral induction of the innate immune responses that alter normally immunosuppressive tumor microenvironments is critical for the lytic virus to mediate tumor rejection. Investigators have designed several classes of viruses to limit viral pathogenicity while enhancing viral immunogenicity. Amgen’s oncolytic virus, Imlygic (T-VEC), is a first-in-class viral therapy for tumors. This engineered HSV-1 virus is armed to expresses GM-CSF, stimulating the differentiation of dendritic cells. Phase III clinical trials indicate a 16% durable response rate in Imlygic treated patients (1). The mechanism remains elusive and the contribution of the GM-CSF has yet to be defined. Imlygic cannot be used in immunosuppressed individuals due to the occurrence of herpetic infections in patients and the potential for life threatening disseminated infection. The focus for future viral therapies is to attenuate the oncolytic virus to eliminate virus-associated disease in patients. Herein, we aim to design an attenuated y-herpesvirus that is deficient in counteracting type I interferon responses as a cancer therapeutic agent. A key feature of tumor cells is their disabled type I IFN response. In the absence of the IFN response, the attenuated y-herpesvirus will lytically replicate in cancer cells while in healthy tissue, characterized by a functional IFN response, replication of the attenuated y-herpesvirus is inhibited. This attenuated y-herpesvirus is completely replication-deficient in severe combined immunodeficiency mice, while robustly eliciting inflammatory and immunomodulatory cytokines, including IFNb, IL-1b, TNFa and IL-12. This approach directly addresses the adverse effects related to disseminated herpetic infection, which limit oncolytic viral therapy regimens. Uncontrolled viral replication also presents a risk to immunocompromised patients, precluding them from being eligible for oncolytic viral therapy. Our new oncolytic virus design overcomes this shortcoming and aims to include patients who have previously undergone aggressive immunosuppressive treatments, such as chemotherapy and radiation. 1. Andtbacka, R. H. I. et al. Journal of Clinical Oncology (2015).
Single Cell analysis of drug resistance in cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We propose to investigate at a single cell level the molecular mechanisms that cause development of drug resistance of breast cancer to Paclitaxel, a first line therapy for this disease. Resistance is a major hindrance in the effective treatment of breast cancer and results from a resetting of the genomic expression of cancer cells to adapt to the toxic actions of anti-cancer drugs. We showed that chronic Paclitaxel treatment of the TNBC cell line MDA-MB-231 kills the vast majority of the cells. Using single cell RNA-seq, we showed that the genomic expression profile of the tolerant cells varies dramatically from drug naïve cancer cells and results in the expression of a unique family of single nucleotide RNA variants (SNVs) in the cancer cells. The molecular changes primarily affected cellular pathways targeted by Paclitaxel to compensate for the drugs actions. Drug resistance is maintained as the cancer cells expand and we propose to use a novel nanopipette/nanoGenomics technology to determine how the genomic changes that direct cancer cells to resist Paclitaxel are transferred from single parent to daughter cells as the resistant cells proliferate. To do this, we will make MDA-MB-231 cells resistant to Paclitaxel, use the nanopipette to tag the few resistant cells with carboxyfluorescene and use fluorescent microscopy to monitor the single labeled cells to identify daughter cells after division. We will then use the nanopipette to extract the RNA from single resistant cells for whole transcriptome analysis (WTA). These studies will determine whether genomic changes induced in the resistant cells are maintained from generation to generation and help to identify those changes most important for drug tolerance. We will use the same technique to identify genomic changes in the cancer cells are they regain sensitivity to Paclitaxel after drug removal to reveal what genomic make up in the cells is critical for Paclitaxel anticancer activity. These studies may provide information that can be used to devise approaches to overcome resistance and reveal a genomic signature to use for diagnosing development of resistance in patients undergoing anticancer therapy.
Antimicrobial and rheological properties of benzoyl peroxide formulated polycarbophil/carbomer 934P hydrogel
Creators: name: Xu, Shiqi
Publisher: name: No Publisher Supplied
Year: 2014

description: BACKGROUND: The human vagina is colonized by a variety of indigenous microflora; in healthy individuals Lactobacillus is a predominant bacterial genus while those with bacterial vaginosis (BV) carry a variety of anaerobic bacteria. The disruption of healthy microflora and shift to primarily facultative anaerobic bacteria leads to microbial disease. Benzoyl peroxide (BPO) is chosen as a new antimicrobial agent since it is listed as safe for use in bleaching in food product and as an active ingredient of acne topical treatments. Polycarbophil/Carbomer 934P are chosen to be the network polymers of the hydrogel to encapsulate BPO, due to their good muco-adhesion.  EXPERIMENTS: In this study, the antimicrobial activity of BPO against Gardnerella vaginalis, one of the primary causative agent of BV, and their safety for vaginal lactobacilli such as L. acidophilus, L. gasseri, L. plantarum, and L. vaginalis is evaluated using a well diffusion assay, direct contact assay and diffusible agent assay. The rheological properties of the formulations are measured using an oscillation frequency sweep, an oscillation shear stress sweep and a flow shear rate experimental design.  RESULTS: It is shown that in the well diffusion assay G. vaginalis is inhibited at 0.01% (w/w) hydrogel-encapuslated BPO and that the tested Lactobacillus spp. are inhibited at 2.5%.   In direct contact assays (cells grown in a liquid culture containing hydrogel, hydrogel containing 1.0% BPO or BPO particles), hydrogels loaded with 1.0% BPO caused 6-log reduction of G. vaginalis. Conversely, three of the lactobacilli spp. are not inhibited while L. acidophilus growth is delayed. Encapsulation of BPO into polycarbophil/Carbomer 934P hydrogel improves its antimicrobial activity against G. vaginalis.  The rheological properties of the hydrogel formulation are not greatly compromised by encapsulation of 1.0% BPO. The new formulation still possesses a solid-like behavior, with a low yield stress and a high viscosity after diluted.  CONCLUSION: Hydrogel containing BPO can be a new drug in BV treatment based on its antimicrobial activity on BV-associated pathogen/not on healthy vaginal lactobacilli when it is encapsulated into polycarbophil/Carbomer 934P hydrogel, and its good rheological properties.
Synthesis of Novel Lankacidin Microtubule Stabilizers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The lankacidin class of natural products was discovered in 1960 and was found to have potent antitumor and antibiotic properties. While the mechanism of antibiotic action of this class is well characterized, the mechanism by which they exhibit in vitro antitumor activity against a variety of models (e.g., L1210 leukemia, B16 melanoma, 6C3 HED/OG lymphosarcoma) was unknown until recently. In October 2016, Ayoub et al. published a study elucidating Lankacidins’ ability to stabilize microtubules and to displace taxoids from their binding site (J Med Chem 2016, 59, 9532–9540). Microtubule stabilizers such as paclitaxel remain front-line therapy for a variety of cancers, but are accompanied by myriad side effects, many of which are not directly related to their canonical mechanism of action. The discovery and optimization of new therapeutics that stabilize microtubule formation but minimize deleterious side effects would be a welcome advance in the battle against cancer. Lankacidins have been used as antibiotics in veterinary medicine for decades, lending credence to their safety in mammals. Further structural optimization is required, however, before they could be considered suitable for use as chemotherapeutic agents in humans. The largest barrier to the optimization of the lankacidin class is the dearth of methods to modify their complex chemical architectures. We propose the development of a platform for the synthesis of lankacidins from a pool of simple, readily available chemical building blocks. This platform will enable the first systematic exploration of the structure–activity relationships of this class. Additionally, the proposed research will provide an avenue to modify lankacidins to increase potency, improve chemical stability, optimize pharmacological properties, and decrease toxicity. This project also offers great potential to advance understanding of microtubule stabilization by providing access to novel chemical probes. The proposed work is an ideal candidate for CRCC funding because a) this is a new project related to cancer, and the first such project in my nascent laboratory, b) given seed funding, the proposed research has a high probability of becoming competitive for larger, long-term grants, and c) our platform has the potential to both advance cancer research and to generate new cancer therapeutics.
Improve bioaccessibility of quercetin using pseudo-organogel based nanoemulsions
Creators: name: Xu, Xuechen
Publisher: name: No Publisher Supplied
Year: 2014

description: Flavonoids which are widely distributed in plants can be categorized as flavonols, flavanols, flavanones, flavones, anthocyanidin and isoflavones. Quercetin (3, 3’, 4’, 5, &-pentahydroxylflavone) accounts for the largest percentage of flavonol intake in the diet. Like many other flavonoids, quercetin has many health-promotion and disease-prevention benefits. However, its low solubility in water and gastric fluid leads to a low bioavailability in vivo. Lipid-based formulations, such as O/W nanoemulsions and solid lipid nanoparticles have been developed to increase the bioaccessibility of flavonoids. Modern delivery systems such as organogel or pseudo-organogel based emulsions have not yet been studied as quercetin delivery vehicles.   In this study, pseudo-organogel and pseudo-organogel based emulsion systems have been developed for oral delivery of quercetin to improve its bioaccessibility. The formation of pseudo-organogel inhibited quercetin crystallization in the oil phase. Using mixture of limonene and medium chain triglyceride (MCT) at the ratio of 2:8 (w/w), solubility of quercetin was increased by 40 times compared to quercetin in MCT at room temperature. Bioaccessibility and the extent of lipolysis were determined for the pseudo-organogel based emulsion system. After the first 30 min of digestion, the extent of lipolysis of the pseudo-organogel based emulsion (&1.9 %±1.2 %) was significantly higher (p<0.001) than that of the quercetin loaded oil mixture (same oil mixture as that used to form pseudo-organogel based emulsion) (54.0 %±0.6 %). The percentages of bioaccessibility of quercetin in oil mixture and in pseudo-organogel based emulsion were determined to be (35.6 % ± 0.6 %) and (49.&%±5.3%) respectively, which were significantly higher than that of quercetin in water suspension (less than 3 %). With a higher and stable loading of quercetin, and the improved bioaccessibility, this pseudo-organogel based emulsion system of quercetin may have potential applications in food, cosmetic and pharmaceutical industries.
Polynemidae Rafinesque 1815
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Polynemidae

description: Family Polynemidae Rafinesque 1815 (Fig. 3M). Threadfins, Tassel-Fishes, Bobos; Bobos, Barbudos
Description: Body elongate, compressed; up to 46 cm in length; snout short, conical, translucent, overhangs mouth; mouth moderate, inferior, with bottom lip extending to front, but no top lip; tooth bands of top jaw touching in center; eyes large, longer than snout, with fatty cover, at front of head; preopercle serrated; scales rough; lateral line extends onto caudal fin; pectoral fin low on side, divided in two portions, the upper portion a normal fin, with 12–19 rays, the lower portion, under gills, with 3–16 long, free rays; two well separated dorsal fins, the first one with eight spines and the second one with one spine and 11–15 rays; pelvic fins well behind the pectoral fin base, under the first dorsal; anal fin base short, with three spines and 10–18 rays; caudal fin forked (Robertson & Allen 2015).
Distribution: Marine (often brackish), rarely freshwater; worldwide, all tropical and subtropical seas (Robertson & Allen 2015). One genus and three species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 41, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
5 keys for happy, healthy family eating
Creators: name: Yu, Jessica Samantha
Publisher: name: No Publisher Supplied
Year: 2014

description: Approximately one-third of children and teenagers between the ages of 2 and 19 living in the United States today are considered overweight or obese. Previous research suggests that parents may play a complex role in the development of childhood overweight and obesity, and that parental over-control of child eating and feeding may put a child at particular risk for increased weight. Interventions to reduce parental over-control of eating have been developed, yet a research-practice gap exists in which recruitment of parents for such interventions has proven challenging. Using a previously studied intervention (5 Keys for Happy, Healthy Family Eating) to reduce parental control over child eating as a model obesity prevention program, the current study was comprised of two inter-related sub-studies. The goal of the first was to help bridge the research-practice gap by building community-research partnerships, identifying key recruitment strategies, and interviewing parents and community stakeholders to help elucidate barriers to parent participation in prevention interventions. The goal of the second was to examine the effectiveness of 5 Keys in reducing parental over-control of eating in the sample of participants successfully recruited for the study. In the first study, 11 collaborations were built, 6 sites were particularly active in participant recruitment for 5 Keys, and 30 parents, participants, and community stakeholders were interviewed to identify key themes in parents’ hesitation to engage in prevention initiatives like 5 Keys. The following themes were identified: lack of time; parents’ desire for a “convenient” program; parents’ desire for family-based interventions; and parents’ desire for “short and sweet” solutions. In the second study, 10 overweight parents completed the 5 Keys intervention. By the end of five sessions, four of 10 demonstrated clinically meaningful reductions in parental pressure on child to eat and six of 10 demonstrated clinically meaningful reductions in parental restriction of child eating. Recommendations are made for how to engage with both community partners and parents to further refine 5 Keys and similar obesity prevention interventions and test their effectiveness and acceptability by parents and community members.
Transdifferentiated dendritic cells as cancer vaccines
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Therapeutic vaccination of cancer holds much theoretical promise but has not achieved practical efficacy. Cancer vaccines require potent antigens representative of the cancer and strong adjuvants that can overcome the immune suppressed environment of a cancer patient. We recently identified a cancer-derived “adjuvant” in the form of the cytokine interleukin 17D (IL-17D), but this cytokine needs to be combined with the appropriate antigenic stimuli to produce an efficacious antitumor immune response. Indeed, the major limitation of current cancer vaccines is in the identification of a suitable vaccine antigen that is expressed in cancer cells but not in normal cells. This limitation can be addressed by sequencing the genome of a cancer cell and identifying mutations, or neoantigens, that are unique to the cancer cell and not expressed in normal cells. Although genome sequencing can identify certain neoantigens, it cannot identify every single one, nor can it predict which neoantigens would be the best ones to include in a vaccine. In this grant, we propose to convert a cancer cell into a dendritic cell (DC). DCs are professional antigen presenting cells that have the natural ability to present antigens to stimulate antitumor T cell responses. In converting a cancer cell into a DC, we generate a novel cell type that has the same genome and therefore expresses the same neoantigens as a cancer cell. Importantly, the DC has professional antigen presentation capabilities and will stimulate immunity. Previous studies have shown that two transcription factors, C/EBPa and PU.1, can convert fibroblasts or lymphoid malignancies into macrophages via a transdifferentiation pathway. The reprogrammed macrophages behave like normal macrophages and can phagocytose and present antigen and importantly do not form tumors in vivo. Building on these findings and our expertise in IL-17D and innate immunity, we propose to convert IL-17D-transfected cancer cells into DCs. This would combine a strong adjuvant (IL-17D), a strong antigen presenting cell (DC), and suitable neoantigen targets (derived from the genome of the cancer cell), thus representing the ideal vaccine for use in patients or in the manufacturing of T cells for adoptive immune therapy.
Copper ion adsorption by chitosan gel nanoparticles and calcium-alginate gel beads for water purification applications
Creators: name: Yu, Kun
Publisher: name: No Publisher Supplied
Year: 2014

description: Water purification is emerging as a critical need as resources become increasingly limited. Chitosan and alginate are both low-cost natural carbohydrate materials used for the removal of heavy metal ions from aqueous solutions. The objective of this research is to enhance understanding of the process and mechanisms of copper ion adsorption by these biopolymer gel particles at multiple size scales, with the aim of guiding the next generation of biosorbent design for water purification applications.     First, the equilibrium adsorption capability of copper ions from copper sulfate solution onto chitosan gel nanoparticles, calcium-alginate gel microbeads, chitosan/alginate combination particles and large alginate gel beads at fixed pH was studied. Results show that the adsorption behavior of chitosan and alginate in the low concentration region follows the Langmuir isotherm. Chitosan gel nanoparticles exhibit a minor increase in adsorption capacity compared to other forms of chitosan.  Alginate has significantly higher capacity than chitosan, which can be attributed to a comparatively higher density of adsorption sites. Combination particles consisting of alginate microbeads coated with chitosan nanoparticles possess an intermediate maximum adsorption capacity, corresponding to the weight ratio of the alginate and chitosan.    Also, adsorption kinetics of copper ions onto calcium-alginate gel microbeads, chitosan/alginate combination particles and large alginate gel beads were investigated. It was observed that the adsorption kinetics of large alginate gel beads was much faster than that of alginate microbeads and combination particles. The adsorption of copper ions on to combination particles was slightly faster than on to plain alginate microbeads. A pseudo-second order kinetic model successfully predicted the adsorption behavior over the whole range of studies, indicating that chemisorption is the rate controlling step and the chemisorption reaction is second order.     Moreover, the adsorption behavior of fixed-bed columns packed with large alginate gel beads was studied by varying the column size and volumetric flow rate. The column had shorter active life at a higher flow rate, or at a smaller size. The Thomas model, Adams-Bohart model and Yoon-Nelson model successfully fit experimental data, allowing prediction of the breakthrough time.
Modeling and control of single-track vehicles
Creators: name: Zhang, Yizhai
Publisher: name: No Publisher Supplied
Year: 2014

description: Single-track vehicles, such as motorcycles and bicycles, not only provide an everyday transportation means and recreational sport, but also offer an excellent platform to study physical human-machine-environment (HME) interactions. The main goal of this dissertation is to present a modeling and control system design framework for HME interactions in single-track vehicle systems.    The dissertation focuses on three aspects: autonomous vehicle design, vehicle-environment interaction, and human-vehicle interaction. First, we propose novel modeling and control designs for riderless single-track vehicle to achieve agile maneuver navigation and stationary balancing. To achieve agile maneuver, the zero lateral velocity nonholonomic constraint at the tire contact point is relaxed. An empirical tire-road friction model is explicitly considered in the dynamic model. An external/internal convertible (EIC) model-based controller is designed for both trajectory tracking and path following strategies. Two different control designs are then presented to balance the stationary bicycle through steering control and gyroscopic actuator control, respectively. To capture the vehicle-environment interaction, the second part of the dissertation focuses on the study of the tire-road interaction. A high-fidelity tire model is proposed and built on the calculation of the deformation  and friction force distributions in stick-slip transition. An in-situ sensing technique is also developed to directly measure the friction force distribution. The model and the sensing development can be further used for facilitating real-time friction parameter estimation and vehicle safety control. The third part of the dissertation mainly discusses the human-vehicle interaction. A dynamic model is first proposed to capture the physical rider-bicycle interaction. A novel pose estimation approach is developed to integrate the wearable inertial sensors with on-board force sensors.  A balancing design is finally presented to control the stationary rider-bicycle interaction.  All the modelings and control designs in the dissertations are validated through extensive simulations and experiments.    The outcomes of the dissertation provide not only a modeling and control framework but also a physical experimental platform to study the unstable HME interactions. We discuss the future research direction at the end of the dissertation.
Eutrigaster (Graffiona) montecyanensis Sims 1987
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Eutrigaster
Eutrigaster montecyanensis

description: Eutrigaster (Graffiona) montecyanensis Sims, 1987
Eutrigaster montecyanensis Sims, 1987 J. Nat. Hist. 21: 435
Eutrigaster (Graffia) franzi Csuzdi & Zicsi, 1991 Acta Zool. Hung. 37 (3–4): 183.
Eutrigaster (Graffiona) montecyanensis: Csuzdi 1995 Ann. Naturhist. Mus. Wien 97B: 104.
Remarks. E. (G.) montecyanensis has been described as a proandric species. Csuzdi (1995, 2000) revised the syntypes of montecyanensis and observed that it is holandric with two pairs of testes in 10, 11 and two pairs of vesicles in 11, 12.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Evaluating the role of phospholipase D1 in pancreatic cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic ductal adenocarcinoma (PDA) is a complex and lethal cancer with unsatisfactory treatment options. Therefore, the magnitude of this problem mandates the search for new strategies to combat this disease; being the identification of new targets for treatment a critical component. Phospholipase D1 (PLD1), a lipid-signaling enzyme, has been shown to play a role in the progression of various types of cancer. For example, PLD1: a) is increased in abundance or activity in various human cancers; b) is linked with proliferative signaling and resistance to cell death, and c) promotes tumor growth and metastasis. In addition, PLD1 has been recently shown to be elevated in clinical samples of pancreatic cancer, and inversely correlate with patient survival. These findings suggest the potential use of PLD inhibitors as cancer therapeutics. However, to date, there is a dearth of information regarding the exact role played by PLD1 in pancreatic cancer. Preliminary studies in our laboratory have shown in animal models of pancreatic cancer, that inhibiting PLD1 reduces pancreatic tumor growth, extends survival and enhances the chemotherapeutic effect of gemcitabine, the most commonly used drug for treating patients suffering from pancreatic cancer. Based on the above, the long-term goals of this project are to understand the role of PLD1 in PDA, to find out whether PLD1 can be a useful new target for PDA treatment. Specifically, the objective of this proposal is to define the role of PLD1 in PDA growth. We hypothesize that PLD1 is a key enzyme in PDA growth. We will employ, biochemical, molecular, and in vivo studies to evaluate this hypothesis and to advance PLD1 as a novel therapeutic target. Accordingly, we will pursue the following specific aims: 1) Determine the role and mechanism of PLD1 in regulating PDA progression; and 2) Establish and define whether PLD1’s role in PDA growth is critical in both tumor cells and in the microenvironment. At the completion of these studies, we expect to have deciphered key functions of PLD1 in pancreatic cancer. These results may allow us to define and establish PLD1 as a novel and heretofore unappreciated major regulator of pancreatic cancer progression. Moreover, we expect to use this CRCC project to obtain key preliminary data to submit a competitive grant proposal for external funding.
Polydactylus approximans
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Polynemidae
Polydactylus
Polydactylus approximans

description: Polydactylus approximans (Lay & Bennett 1839). Blue Bobo; Barbudo Azul, Bobo Blanco, Barbudo de Seis Barbas
Vouchers: (other collections) CAS 51246 (12) and TCWC 44419 (3). Distribution: Eastern Pacific Ocean; from central California, USA, to Chile, including the Cocos, Malpelo and Galapagos islands; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER, PN and Ni (Pacific); 0–8 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 211; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Allen (2015: 1402; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 42; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 41, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Earthquakes in New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1973

description: This report includes: an introduction, elementary seismology for the layman, a list of seismographs in and near New Jersey, minor tremors in Bergen County, listing of earthquakes in New Jersey, detailed information on earthquakes listed and a bibliography. The tabulations include all the major and minor earthquakes large enough to be felt in New Jersey, and a few (too weak to be felt) detected by very sensitive seismographs, along with a verbal description.
Eutrigaster (Graffiona) michaelseniana Csuzdi & Zicsi 1991
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Eutrigaster
Eutrigaster michaelseniana

description: Eutrigaster (Graffiona) michaelseniana Csuzdi & Zicsi, 1991
Eutrigaster (Graffia) michaelseniana Csuzdi & Zicsi, 1991 Acta Zool. Hung. 37 (3–4): 187. Eutrigaster (Graffiona) michaelseniana: Csuzdi 2014 Zootaxa 3811: 149.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011