title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ°Ð½ÐµÐ²ÑÑ Ð¿Ð¾ÐºÑÑÑÐ¸Ð¹ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ¿ÑÐµÑÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of wound coatings based on compressed collagen
Creators: name: ÐÐ°Ð¿Ð¸Ð½Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½
ÑÐ°Ð½ÐµÐ²Ð¾Ðµ Ð¿Ð¾ÐºÑÑÑÐ¸Ðµ
ÑÐ¿ÑÐµÑÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½
ÑÑÐ¸Ð²Ð°ÑÑÐ¸Ðµ Ð°Ð³ÐµÐ½ÑÑ
Ð³Ð°Ð»Ð»Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ°
ÐºÐ°ÑÐ±Ð¾Ð´Ð¸Ð¸Ð¼Ð¸Ð´Ñ
ÑÐ¸Ð±Ð¾ÑÐ»Ð°Ð²Ð¸Ð½
Ð³Ð¸Ð°Ð»ÑÑÐ¾Ð½Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ°
collagen
wound coating
compressed collagen
crosslinking agents
gallic acid
carbodiimides
riboflavin
hyaluronic acid

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description: The subject of the graduate qualification work is "Development of wound coatings based on compressed collagen". The given work is devoted to the creation of a wound coating based on compressed collagen. The coating is characterized by improved strength characteristics, increased resistance to enzymatic degradation, and the ability to be easily modeled on a wound. The fibrillar structure of such coatings is formed without the use of a culture medium. In the work, optimal conditions were selected to produce pressed collagen cloths, their stabilization was carried out by crosslinking agents such as 1-ethyl-3-(3-dimethylaminopropyl)Â carbodiimide, gallic acid and riboflavin. Studies have shown the high efficiency of using all the above crosslinking agents to increase the resistance of collagen coatings to enzymatic degradation.A technique for modifying collagen coatings with hyaluronic acid has also been developed. 1-ethyl-3-(3-dimethylaminopropyl)Â carbodiimide, gallic acid and riboflavin were also used to prevent the leaching of hyaluronic acid from the coating structure. All these agents have demonstrated their effectiveness in solving this problem.Â The obtained results can be used for regenerative medicine tasks.