cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of O-Linked N-Acetylglucosamine (O-GlcNAc) in Metabolic Regulation
Creators: name: Soesanto, Yudi Aditya
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism
Glucosamine

description: Attachment of O-linked (3-N-acetylglucosamine (O-GlcNAc) to the hydroxyl  group of serine and/or threonine residues of nucleocytoplasmic proteins is one of the  more common post-translational modifications of proteins. Although O-GlcNAc has been  shown to be essential for cell viability, aberrant increases in O-GlcNAcylation of proteins  in different tissues have been shown to mediate pathological effects of hyperglycemia as  observed in the type 2 diabetes. The physiological function of O-GlcNAc in normal  physiology, however, has not been well studied. We have therefore overexpressed the  enzyme p-iV-acetylglucosaminidase (O-GlcNAcase), which catalyzes the removal of the  O-GlcNAc modification from proteins, in the liver or pancreatic P-cells of normal  C57BL/6J mice.  We demonstrate that overexpressing O-GlcNAcase in euglycemic mouse liver  through tail vein injection of adenovirus resulted in increased Akt signaling, an important  arm of the insulin signal transduction cascade. We also observed that the increased in Akt  phosphorylation was not due to increased activity of signaling pathway upstream of Akt.  Despite a significant decrease in the transcript level of the gluconeogenic enzyme  glucose-6-phosphatase, consistent with increased Akt activity, there were no significant  differences in the glucose or insulin levels after 3 days of O-GlcNAcase overexpression,  although fasting blood glucose levels were moderately lowered after 5 days of overexpression. These findings demonstrate the role of hexosamine biosynthesis pathway  (HBP) as a nutrient sensing pathway not only in pathologic states of diabetes or caloric  excess but also in normal physiology.  In P-cells, O-GlcNAcase was overexpressed in transgenic mice under control of  the rat insulin promoter. O-GlcNAcase overexpression in younger (3 months old) mice  results in decreased circulating fasting insulin levels. This decrease was paralleled by  decreased insulin mRNA and islet insulin content. Further studies demonstrated an  increase in pancreatic insulin content with increased p-cell mass, suggesting a possible  defect in insulin exocytosis associated with O-GlcNAcase overexpression. However,  when the mice were challenged with a high fat diet, O-GlcNAcase seems to protect the pcell  function as determined by fasting insulin and glucose levels.  Together, the present studies demonstrate that O-GlcNAc function to regulate  metabolic pathway under physiologic and normoglycemic condition. In addition,  decreased O-GlcNAc protects from the adverse effects of hyperglycemia as seen in type  2 diabetes, both through increased Akt signaling and protection of the P-cell function  under conditions of nutrient stress.
Brief an [Johann III Bernoulli]
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1788

description: von J[ean] H[yacinthe] de Magellan
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Copper metallation of cytochrome oxidase
Creators: name: Nittis, Thalia
Publisher: name: University of Utah
Year: 2012

description: Cytochrome c oxidase (COX), the terminal enzyme of the electron transport chain, requires three copper ions for function. The copper ions need to be ferried from the cytoplasm to the mitochondrial inter-membrane (IM) space, and subsequently inserted into COX subunits 1 and 2. Cox17 is proposed to be the copper chaperone that transports the copper ions to the mitochondria. Consistent with this role, Cox17 is present in both the cytosol and mitochondrial IM space, and binds Cu(I) within a polycopper cluster. Sco1, a mitochondrial inner membrane protein, is proposed to accept the ions from Cox17, and donate them to Cox2. Sco1 was first implicated in this pathway by the observation that the respiration-defective phenotype of ?cox17 cells could be suppressed by high copy SCO1. The aim of this thesis is to further characterize Cox17 and Sco1, which would lead to better understanding of the process of copper metallation of COX. In this study mutational analysis on yeast Cox17 was used to identify three of seven cysteinyl residues as Cu(I)-binding ligands. These residues, which are present in a conserved CxCC motif, are also critical for Cox17 function. Mitochondrial import of Cox17 is independent of Cu(I) binding. Mutation of a cysteinyl residue located near the C-terminal end of the protein results in reduced levels of Cox17 inside the mitochondria, suggesting that this portion of the protein may contain a mitochondrial targeting sequence or protein docking site. The work described in this thesis shows for the first time that purified Sco1 binds one Cu(I) ion per monomer. The Cu(I) ion in Sco1 is ligated via two cysteines present in a conserved CxxxC motif, and a conserved histidine. As with Cox17, all three residues in Sco1 involved in Cu(I) ligation are also essential for function. Size-exclusion chromatography of solubilized mitochondrial and cytoplasmic lysates shows that Sco1 forms oligomers in vivo. Oligomerization is not dependent on Sco1 function. Lack of either Cox17 or Cox2 also does not affect Sco1 oligomerization.
Sensory descriptions in recalling a recent bone marrow transplant experience
Creators: name: Sutherland, Carolyn Woodruff
Publisher: name: University of Utah
Year: 2012
Subjects: Chemotherapy
Radiation

description: The purpose of this study was to identify sensory descriptions of events and circumstances, typical of a bone marrow transplant (BMT) experience, that could be used to prepare future BMT patients for the transplant experience. The tool for data collection was a questionnaire composed of objective sensory questions relating to the transplant regimen and subjective questions relating to orientation prior to transplantation. A convenience sample of 16 subjects who had completed their BMTs within 6 months of the study, was used. All sensory descriptions used by the subjects were listed, and those that were used by at least 50% of the subjects who recalled each experience were considered appropriate to use for preparation of future BMT patients. The result is a list of concrete objective sensory descriptions which can be used to help new BMT patients construct accurate schemata in anticipation of certain events and circumstances encountered in having a BMT.
Odontolytes landai
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Odontolytes
Odontolytes landai

description: § Odontolytes landai (Balthasar, 1963)
Odontolochus (Odontolytes) landai Balthasar 1963a: 286 (Paraguay)
= Phalangochaeta squamosa Petrovitz 1976: 290 (Ecuador) - Stebnicka and Galante 2007: 135 (syn. nov.)
Distribution. Venezuela (EO): Stebnicka 2002a: 772 (as Auperia squamosa) (EO), 2009a: 33 (as Auperia landai). Other: Balthasar 1963a: 286 (Paraguay - as Odontolochus (Odontolytes) landai);
Petrovitz 1976: 290 (Ecuador - as Phalangochaeta squamosa); Stebnicka 2002a: 772 (Bolivia, Colombia, Ecuador, Guatemala, Mexico, Panama, Paraguay, Trinidad and Tobago - as Auperia squamosa), 2009a: 33 (Bolivia, Colombia, Ecuador, Guatemala, Honduras, Mexico, Panama, Paraguay, Trinidad and Tobago - as Auperia landai).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 35-36, DOI: 10.5281/zenodo.3678492
Additional file 8 of Vanilla bisquits and lobola bridewealth: parallel discourses on early pregnancy and schooling in rural Zambia
Creators: name: Blystad, Astrid
name: Moland, Karen Marie
name: Ecloss Munsaka
name: Sandøy, Ingvild
name: Zulu, Joseph
Publisher: name: figshare
Year: 2020
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 8. Topic guide ‘Adults’.
Odontolytes minutus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Odontolytes
Odontolytes minutus

description: § Odontolytes minutus (Petrovitz, 1973)
Euparia minuta Petrovitz 1973: 188 (Brazil)
Distribution. Brazil: Petrovitz 1973: 188 (as Euparia minuta); Stebnicka 2002a: 765 (as Auperia minuta), 2009a: 34 (as Auperia minuta). Venezuela (EO): Stebnicka 2002a: 765 (as Auperia minuta) (EO), 2009a: 34 (as Auperia minuta).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 36, DOI: 10.5281/zenodo.3678492
Growth factor expanded-glial restricted precursor cells: support of neurons by derived astrocytes
Creators: name: Howard, Jill Kristin
Publisher: name: University of Utah
Year: 2012
Subjects: Growth
Nerve Growth Factors

description: Growth factor expanded precursor cells may be useful for therapeutic strategies in central nervous system tissue repair and regeneration.  The ability to maintain precursor cells in a state of self-renewal allows for the production of large numbers of cells.  The use of glial-restricted precursor cells (GRP) is therefore of great interest in the use of derived astrocytes for reparative strategies, such as on synthetic devices for guiding nerve growth.  GRP cells could be a critical improvement because of the decrease in neuron supporting properties that differentiated astrocytes display with time in culture.  In accordance to what has been observed for differentiated cells, precursor cells may also continue to measure elapsed time despite their state of self-renewal.  It has not been addressed whether these internal timing mechanisms results in altered properties of the derived cells.  This study investigated the changes in neurite outgrowth and cell adhesive properties of astrocytes derived from growth factor expanded GRP cells over various periods of time in culture.  Astrocytes differentiation was induced after GRP cells were expanded in culture for up to seven weeks.  Cerebella granule neuron adhesion and neurite outgrowth were measured on monolayers of GRP-derived astrocytes at weekly intervals.  Extended self-renewal of GRP cells in culture did not pause the functional changes associated with astrocytes maturation and astrocytes derived from expanded progenitors increased their surface area in correspondence with the length of time culture.  In addition to the flattened morphologies, prolonged proliferation also resulted in decreased chondroitin sulfate proteoglycan expression.  These changes in astrocytes morphology and proteoglycan expression correlated with decreased neurite out-growth and cell adhesion, and may correspond to the capability of GRP cell to intrinsically time the progress of development despite their state of self-renewal.  An important implication of these findings is the insight that growth factor expansion of precursor cells in culture resulted in cells with a progressive degrease in neuron supporting properties.
Brief an [Johann III Bernoulli]
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1784

description: von [Jean Hyacinthe de] Magellan
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Additional file 5 of Vanilla bisquits and lobola bridewealth: parallel discourses on early pregnancy and schooling in rural Zambia
Creators: name: Blystad, Astrid
name: Moland, Karen Marie
name: Ecloss Munsaka
name: Sandøy, Ingvild
name: Zulu, Joseph
Publisher: name: figshare
Year: 2020
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 5. Interview guide ‘District officials’.
About Forward Press : Official version
Creators: name: Forward Press
Publisher: name: Zenodo
Year: 2022
Subjects: Ethics of journalism

description: FORWARD Press began as a monthly magazine published from New Delhi. Now, it has moved on to becoming this active website and a publisher of books under the Forward Press imprint. These are projects of the Dalitbahujan Emancipation International (DEI). The magazine made its debut in the newsstands in June 2009 with the cover story titled “The Victory of Aspiration”. Ivan Kostka, who was once the Bombay bureau chief of India’s first youth magazine, JS or Junior Statesman, is the founding editor of FORWARD Press. He has had a life-long interest and engagement with Dalits and other Bahujan groups, starting with the Dalit Panthers in the early 1970s.
description: Accessed on 17 July, 2022
Automated collection of infusion pump data: nurse usage and perceptions
Creators: name: Dalto, Joseph Desmond
Publisher: name: University of Utah
Year: 2012
Subjects: LDS Hospital
Utah

description: Automated collection of infusion pump data has existed at LDS Hospital since 1986 using a prototype Medical Information Bus (MIB). No study to date has evaluated how nurses utilize the MIB for infusion pump data. This research presents two studies on utilization of automated collection of infusion pump data. The first study was conducted in four adult Intensive Care Units (ICUs) at LDS Hospital and evaluated nurse use and perceptions of automated data collection. The second study was conducted in the ICU at McKay-Dee Hospital and collected data before and after the implementation of an automated data collection system using the IEEE 1073 MIB standard.  The study on nurse usage of automated data collection at LDS Hospital was conducted from mid December of 1995 to mid March of 1996. Measured variables were the medication infused, the method of infusion, and the number of rate changes for each infusion. The nurses used the prototype MIB for 53.4% of 9,644 infusions. Of the 22,199 rate changes documented during this study, 99.35% (22,055) were documented by the MIB. To evaluate nurse perceptions of automated data collection a paper survey was distributed to the nurses in October of 1995. Of the 158 surveys distributed, 72 were returned giving a response rate of 46%. The nurses felt that the prototype MIB improved the accuracy (p < 0.001), timeliness (p < 0.001), and completeness (p < 0.001) of documentation.   Of the   72   nurses   who   responded, 67 felt that the prototype MIB saved them time.  The repeated measures trial at McKay-Dee Hospital was conducted from June 1996 through March 1997 and reported data on 6,209 infusions. Before implementation of the MIB, nurses documented an average of 0.69 rate changes per infusion. After implementation, an average of 1.32 rate changes per infusion were documented. The nurses used automated data collection for 40.7% (985) of the infusions which accounted for 76.84% (2,458) of the rate changes documented.  The results of these studies showed that automated data collection systems can provide a more complete clinical record. Furthermore, nurses perceived that automated data collection improved the quality of documentation and saved them time.
Odontolytes waoraniae
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Odontolytes
Odontolytes waoraniae

description: Odontolytes waoraniae (Stebnicka and Skelley, 2005)
Auperia waoraniae Stebnicka and Skelley 2005: 35
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Para.). Other: Stebnicka and Skelley 2005: 35 (Ecuador - as Auperia waoraniae); Stebnicka 2009a: 37 (Ecuador - as Auperia waoraniae).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 36, DOI: 10.5281/zenodo.3678492
Study of nurses' attitudes and anxieties toward death and dying
Creators: name: Seegmiller, Mary Elizabeth Mester
Publisher: name: University of Utah
Year: 2012
Subjects: Psychological: Attitude

description: The subject of death and dying are of growing concern to all nurses, particularly psychiatric nurses.  This study was conducted to compare attitudes and anxieties about death between nurses who graduated from a two-year associated degree, or a four-year baccalaureate program in nursing.  The sample consisted of 510 registered nurses (65% return rate) who answered a mailed questionnaire.  They graduated between the years of 1967-1971 from Brigham Young University, Salt Lake City and Prove, Weber State College, Ogden, and the University of Utah, Salt Lake City.  The respondents were also divided into subgroups according to work specialization and the extent to which the investigator perceived them to have contact with critically ill and dying patients.  The questionnaire employed the semantic differential and included Emotionality and Evaluative Scales developed by Folta (1965), and an Anxiety Scale constructed by Forrest (1970).  An analysis of variance was done to compare responses to the three scales for the two and four-year programs, and for the sub grouping of nurses' area of interest.  Variables such as educational degree, years since graduation, years worked and experience with critically ill patients were Interco related with scores on the three scales.  There were no significant differences among the four schools on the scales.  However, many variable were not controlled for which could have influenced this finding.  It is of interest to note the tendency for scores on all scales to be lower with more educational preparation, but the results did not reach statistical significance.  There were no significant differences among the nurses regarding years of total work experience and Evaluative and Anxiety Scores.  Recent graduates were no different in their attitudes toward death and dying than those nurses who had been graduated for longer than one year.  Significant negative correlations were found between total work experience and Emotionality, (-.08, p
Brief an [Johann III Bernoulli]
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1774

description: von J[ean] H[yacinthe] [de] Magellan
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Role of Hoxb13 in caudal axis patterning and prostate development
Creators: name: Economides, Kyriakos D.
Publisher: name: University of Utah
Year: 2012
Subjects: Physiopathology
Vertebrate Hox Genes

description: Vertebrate Hox genes encode a family of homeobox transcription factors that regulate developmental programs and determine the embryonic body plan. These functions have largely been determined by the generation of loss-of-function mutations in vertebrate Hox genes through gene targeting technology in mice. Hoxb13 is the last Hox gene to be identified. It is located 5' of Hoxb9 within the HoxB cluster and is expressed in the posterior regions of the developing embryo, including the tail bud and genital tubercule. Loss-of-function mutations of  Hoxb13 have not been reported, and the function of this gene was unknown prior to the work outlined herein. This dissertation describes the generation of Hoxb13 null mice and the analyses of mutants that lack Hoxb13 function. Hoxb13 homozygous mutants have an aberrant developmental program in the structures that are derived from the process of secondary neurulation which include the caudal vertebrae within the tail, the caudal spinal ganglia, and the secondary neural tube. The phenotype is novel for Hox gene mutant phenotypes in that all of the aforementioned structures display an overgrowth phenotype, and further analyses in the secondary neural tube reveals that the phenotypes are caused by both over-proliferation of cells and failure of the normal apoptotic pathway that removes the secondary neural tube. This dissertation also addresses the function of Hoxb13 in adults. In contrast to its role in limiting growth during development, Hoxb13 also determines a pathway that is specific to the prostatic luminal epithelium ventral lobe. Hoxb13 homozygous mutants do not secrete the ventral prostate specific secretory proteins including p12, a serine protease inhibitor, and p25, a spermine binding protein. Additionally, homozygote mutant ventral prostates secrete polymeric immunoglobulin receptor (pIgR) and androgen binding protein (ABP), which are not normally secreted by the prostate, indicating that the homozygous mutant prostate luminal cells have lost identity. In addition to losing identity, homozygous mutant ventral prostate luminal cells lose polarity, as indicated by the expression of basal cell markers on the apical surface of luminal cells. This dissertation provides analyses of both the developmental and adult functions of Hoxb13 and underscores how a Hox gene that has a very specific function in embryonic patterning can be later recruited for very different functions in adult tissues.
MPEC 2024-H73 : 2007 HW3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Brief an [Johann III] Bernoulli
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1781

description: von [Jean Hyacinthe de] Magellan
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
A brief note on pure shear from An introduction to the Ogden model in biomechanics: benefits, implementation tools
Creators: name: Lohr, Matthew J.
name: Sugerman, Gabriella P.
name: Kakaletsis, Sotirios
name: Lejeune, Emma
name: Rausch, Manuel K.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Mechanics
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Constitutive models are important to biomechanics for two key reasons. First, constitutive modelling is an essential component of characterizing tissues’ mechanical properties for informing theoretical and computational models of biomechanical systems. Second, constitutive models can be used as a theoretical framework for extracting and comparing key quantities of interest from material characterization experiments. Over the past five decades, the Ogden model has emerged as a popular constitutive model in soft tissue biomechanics with relevance to both informing theoretical and computational models and to comparing material characterization experiments. The goal of this short review is threefold. First, we will discuss the broad relevance of the Ogden model to soft tissue biomechanics and the general characteristics of soft tissues that are suitable for approximating with the Ogden model. Second, we will highlight exemplary uses of the Ogden model in brain tissue, blood clot and other tissues. Finally, we offer a tutorial on fitting the one-term Ogden model to pure shear experimental data via both an analytical approximation of homogeneous deformation and a finite-element model of the tissue domain. Overall, we anticipate that this short review will serve as a practical introduction to the use of the Ogden model in biomechanics.This article is part of the theme issue ‘The Ogden model of rubber mechanics: 50 years of impact on nonlinear elasticity’.
Skin circulation in areas prone to pressue ulcerationand adjacent nonsusceptible areas as determined by the thermal recovery method
Creators: name: Hedegaard, Vern
Publisher: name: University of Utah
Year: 2012
Subjects: Blood Supply

description: Pressure ulcers, also called decubitus ulcers and bed sores, are areas of hypoxemic necrosis resulting from compression of capillaries by externally applied pressure.  They most commonly develop in areas of the body subjected to prolonged high pressure, such as the trochanters, sacrum and ischia.  Very little is known about the local skin circulation in these areas.  Reduction of the magnitude and duration of pressure applied to the body surface have been shown to be effective, scientifically based nursing interventions.  Interventions based on increasing skin blood flow, although commonly used, have not shown to be effective or scientifically based.  The purpose of this study was to compare the skin circulation of areas prone to pressure ulceration with the skin circulation of adjacent, less susceptible areas.  The thermal recovery method was use to estimate the skin blood flow over the trochanter and sacrum, and compared to that over the abdomen and groin.  No significant differences were found between the thermal recovery values of the trochanter and groin, or between those of the sacrum and abdomen.  Although subject's thermal recovery values varied widely, no significant differences were observed based on site, age, sex, diastolic blood pressure, or height/weight ratio.  The results of this study indicate a need for continued study of the skin circulation of areas prone to pressure ulceration.  The conclusion of other studies utilizing skin temperature as an index of circulation require reexamination.   The emphasis in nursing intervention should continue to be directed toward relieving pressure, rather than increasing skin circulation.
Brief an [Johann III] Bernoulli
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1773

description: Das zweite Blatt ist beschädigt.
description: von [Jean Hyacinthe de] Magellan
description: Mit Spuren von einer roten Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Passaliolla Balthasar 1945
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Passaliolla

description: PASSALIOLLA Balthasar, 1945
Passaliolla Balthasar 1945: 104
Synopsis. Stebnicka 2000
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 36, DOI: 10.5281/zenodo.3678492
Potential for reactive oxygen speciesmediated DNA damage and cellular multidrug resistance produced by the pyrroloiminoquinone class of marine natural products
Creators: name: Schnabel, Peter C.
Publisher: name: University of Utah
Year: 2012
Subjects: Drug Therapy
DNA

description: The pyrroloiminoquinones (PIQs) are a group of secondary metabolites possessing a para-quinoneimine substituted with a fused pyrrole ring. These compounds vary in their functionalization around the heterocyclic framework and so provide a basis for the comparison of these derivatizations, on biological activity. In this dissertation, preliminary evidence is provided to suggest that genetic deoxyribonucleic acid (DNA) damage involving the iminoquinone may occur through a reactive oxygen species mediated redox pathway. Substantial evidence is also provided to show that these compounds have the potential to generate the multidrug resistance phenotype in cultured cells. Relevant biochemical and electrochemical attributes of the PIQs are described. Experimental evidence is provided for the cleavage of DNA, after PIQ reduction, in the presence of molecular O2. Ultraviolet absorbance measurements give structural information about the reduced species and demonstrate the reversibility of the reduction in the presence of molecular oxygen. It is also demonstrated that the extent of DNA cleavage produced by each of the pyrroloiminoquinones is directly related to the amount of energy necessary to reduce the PIQs by one electron and the reversibility of that one electron reduction. DNA intercalation is shown not to correlate suggesting that this attribute of the PIQs is of lesser importance. Prevention of DNA damage in solution by reduced PIQ is then achieved with ascorbate, suggesting a radical-mediated process. Cellular responses to PIQ treatment are addressed. The lack of correlation between >in vitro cytotoxicity and reductive DNA cleavage is presented and addressed in terms of possible additional mechanisms of PIQ activity. In contradiction to this, indirect evidence of ROS-mediated cellular damage in vitro is provided using ascorbate and glutathione in a protection assay. Cellular resistance, a common problem with many chemotherapeutic agents, is investigated. The PIQs are found to be substrates for the P-glycoprotein transporter and this mode of cellular resistance, in effect a cytotoxic stress-response, is investigated. The PIQs are shown to not only be acceptable substrates for Pgp170, but also inducers of Pgp170 expression after continuous treatment. Preliminary evidence supports the hypothesis that substrate recognition of the PIQs by Pgp170 may be an important factor in regulating the extent of Mdr1 expression.
Brief an [Johann III] Bernoulli
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1778

description: von [Jean Hyacinthe de] Magellan
description: Der Brief trägt auf dem zweiten Blatt ein schwarzes Wachssiegel.
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Sleep in the elderly cancer patient
Creators: name: Tadje, Marsha
Publisher: name: University of Utah
Year: 2012
Subjects: Cancer
Patients

description: Sleep quality disturbances are reported in 15% to 30% of the U.S. adult population, including half of those aged ? 65.  Sleep disruptions in individuals with cancer have been reported clinically but are yet to be verified in the literature.  Sixty percent of all cancer occurs in persons aged ? 65.  Because elderly persons are more likely to report sleep disruptions and more likely to be diagnosed with cancer, this population may be more vulnerable to sleep disruptions than the general oncology population.  The purpose of this study was to determine if there are differences in sleep quantity and sleep quality between individuals aged < 65 and those aged ? 65 and to determine if demographic and clinical factors affect sleep quality in the elderly cancer population.  Patterns of sleep disruption in the elderly population were also reported.  Secondary analysis was conducted on data from a descriptive correlational study on sleep, pain, and fatigue in cancer patients.  The Pittsburgh Sleep Quality Index (PSQI) was used to determine perceived sleep disruption, use of medication, and daytime dysfunction.  Fifty-seven of the 214 participants in the study were ? 65.   No differences were found in sleep quantity or overall sleep quality between the older and younger groups.  Sleep duration, a categorical measurement of sleep quantity, was significantly different between groups(X2 = 14.339, p =
Additional file 1 of Chronic hypoxaemia and gender status modulate adiponectin plasmatic level and its multimer proportion in severe COPD patients: new endotypic presentation?
Creators: name: Mélany Pierard
name: Tassin, Alexandra
name: Legrand, Antoine
name: Legrand, Alexandre
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1.
Additional file 4 of Semantic and cognitive tools to aid statistical science: replace confidence and significance by compatibility and surprise
Creators: name: Rafi, Zad
name: Greenland, Sander
Publisher: name: figshare
Year: 2020
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 4: Figure S2. Deviance statistics for a range of hazard ratios. A deviance function, which corresponds to Fig. 3, the S-value function. Also plotted is the likelihood interval (LI), which corresponds to the 95% compatibility interval. Computed from results in Brown et al. [34]. MLR = Maximum-Likelihood Ratio. HR = 1 represents no association.
Effects of an introduced parasitic nest fly on endemic avian hosts in the Galapagos Islands
Creators: name: Knutie, Sarah Ann
Publisher: name: University of Utah
Year: 2015
Subjects: Conservation
Darwin's finches
Host defenses
Invasive

description: Introduced parasites threaten native host populations in many parts of the world. For example, the introduced parasitic nest fly Philornis downsi has been implicated in the decline of Darwin's finch populations in the Galápagos Islands. Studies have just begun to rigorously test the question of why such parasites are successful, and how they devastate naïve host populations. In this dissertation, I examine the effects of P. downsi flies on two host species in the Galápagos; I explore the underlying mechanisms by which hosts are affected. Using an experimental manipulation of P. downsi, I demonstrate that P. downsi reduces nestling survival of medium ground finches (Geospiza fortis), but not Galápagos mockingbirds (Mimus parvulus) at the same location. This suggests that mockingbirds are tolerant to the effects of P. downsi. Mockingbird nestlings appear to compensate for parasite damage by increasing their energy intake through increased begging and parental provisioning. Mockingbirds also appear to differentially express more genes in response to parasitism than finches. However, mockingbirds and finches express very few of the same genes in response to parasitism, suggesting that P. downsi has different effects on gene expression in these hosts. I also investigated the effects of native parasitic flies Philornis trinitensis on hosts in Tobago to understand why P. downsi is successful in the Galápagos. I show that the effect of P. trinitensis on Tobago hosts is similar to the effect of P. downsi on Galápagos hosts. However, the prevalence of P. trinitensis in Tobago is lower than that in the Galápagos, which may be because there are more enemies of the flies in Tobago compared to the Galápagos. Thus, introducing native predators of P. downsi to the Galápagos may be a promising approach to reducing the effect of P. downsi on finches. Until such predators are identified, I present evidence that self-fumigation by finches can be used as an effective stopgap approach to control P. downsi. My work demonstrates that mockingbird reservoir hosts of P. downsi change their behavior to tolerate parasite damage. In turn, P. downsi can persist in the environment, regardless of future declines of vulnerable finch hosts, unless control methods are implemented.
Additional file 1 of Semantic and cognitive tools to aid statistical science: replace confidence and significance by compatibility and surprise
Creators: name: Rafi, Zad
name: Greenland, Sander
Publisher: name: figshare
Year: 2020
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1: Appendix. Technical details for computations of figures and tables.
Postearthquake repair of precast concrete column-to-footing plastic hinges
Creators: name: Brown, Dylan Neil
Publisher: name: University of Utah
Year: 2014
Subjects: Carbon fiber reinforced polymer
Column repair
Earthquake engineering
Headed rebar
Retrofit, Sesmic

description: Bridge design is moving towards performance-based design in which acceptable levels of damage following an earthquake are prescribed, allowing the possibility to repair and not replace bridges. A repair technique for precast reinforced concrete bridge column-to-footing assemblies constructed with Grouted Splice Sleeve (GSS) connections has been developed. The repair is implemented and verified through laboratory testing and Strut-and-Tie Models (STM). The repair utilizes prefabricated carbon fiber-reinforced polymer shells and epoxy anchored headed mild steel rebar to relocate the column plastic hinge. Prior to the repair procedure, two undamaged, as-built, column-to-footing specimens constructed with GSS connections were tested to failure under a quasi-static cyclic lateral load. During testing, both of the as-built specimens experienced longitudinal rebar fracture, with lateral load carrying capacities degrading to 63%-65% of their ultimate load capacities. The as-built column plastic hinge region was subsequently repaired by increasing the column cross-section from a 21 in. octagonal section to a 30 in. diameter circular section, over a column height of 18 in. The repaired specimens were tested following the same cyclic loading protocol as the as-built specimens. The plastic hinge was successfully relocated to the column section above the repair, and the failure mode was longitudinal rebar fracture in the relocated plastic hinge region. The repaired assemblies had an increase in the ultimate lateral load capacities of 28%-30%, while being capable of maintaining the as-built lateral displacement capacity. To aid in the design of future as-built and repaired assemblies, a conventional STM and a nonlinear STM were developed. Generic modeling parameters were developed, which can be used with varying reinforcement layouts and element geometries. Results from the STM models match the as-built and repaired test results, predicting the ultimate lateral load capacities and nonlinear force-displacement response envelopes.
Brief an [Johann III] Bernoulli
Creators: name: Magalhães, João Jacinto de
Publisher: name: [s.n.]
Year: 1780

description: von [Jean Hyacinthe de] Magellan
description: Mit schwarzem Siegel
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Oktober 2015 Andrietta Wahl
Antithrombin III residue tyrosine-131 serves as a molecular switch during heparinmediated conformational activation of its anticoagulant activity
Creators: name: dela Cruz, Richard Glenn Cua
Publisher: name: University of Utah
Year: 2012
Subjects: Pentasaccharide
Allosteric Activation
Mutants

description: The foundation of this project is the hypothesis that binding of antithrombin III (ATIII) to heparin pentasaccharide (H5) leads to global changes in ATIII structure that starts at its heparin binding site (HBS), propagates throughout the molecule, and culminates with the expulsion of the reactive center loop (RCL) - leading to complete activation of ATIII against Factor Xa (fXa). Structure-based analyses of three ATIII structures led to the identification of residues that are hypothesized to be involved in conformational change propagation. These residues were mutated and analyzed to ascertain their importance.  The first series of mutants, Tyr131 ?Ala, Leu, or Phe, were made to determine the effect of helix D elongation-mediated Tyr on conformational change propagation. Secondly, Leu140, which lies directly between the HBS and the RCL, was mutated to a Val or Phe to assess the contribution of this (?-sheet 2A residue in allosteric activation. The third series, comprised of Tyr131?Leu ATIII variants with RCL-deletion/s Val400, Arg399Val400, or  Arg399Val400Thr401, look into the potential cooperativity of Y131 and RCL residues in depressing endogenous ATIII anti-fXa activity. The contributions of these residues in ATIII structure and function were evaluated by measuring their thrombin and fXa inhibition rates, determining their native to noninhibitory conformation melting temperature, and assessing their heparin binding affinity.  These studies clearly indicate that ATIII allosteric activation is dependent on the investigated residues. Tyr131 and the mutated RCL residues play a crucial role, and act cooperatively, in depressing ATIII anti-fXa activity only. In addition, they are also important in ATIII heparin binding affinity and in maintaining ATIII stability. Additionally, changing Leu140?Phe slightly increased cofactor-independent ATIII fXa inhibition rates, indicating that spacing between helix D and strand 2A promote further conformational adjustments in the molecule, including structural changes that might increase RCL accessibility and/or lead to greater exposure of fXa recognition sites. The mutagenesis studies that were undertaken offer tremendous insight on the conformational events that occur within ATIII following H5 binding and will aid in the development of better anticoagulant therapeutics.
Is an anxious support provider an effective one? Social support provider anxietly and cardiovascular function
Creators: name: Kent, Robert Gordon
Publisher: name: University of Utah
Year: 2015
Subjects: Cardiovascular health
Cardiovascular reactivity
Social network
Social relationships
Social support
Stress reactivity

description: Social support has important and reliable links to physical health. The association of perceived social support with health is particularly well understood, and is consistently found in the reasech literature. Received social support, however, is less reliably linked to health outcomes, and laboratory studies manipulating received support often find it results in heightened physiological reactivity and distress. One factor thought to influence the effectiveness of received social support is anxiety on the part of the social support provider. The present study examined the main and interaction effects of social support provider anxiety and support role within participant dyads (provider, receiver) on reactivity to a assigned to a support role within a dyad, and each dyad was randomized to either a low provider anxiety condition, or to a condition in which heightened provider anxiety was induced with a social evaluation manipulation. Participants completed measures of self-esteem, state and trait anxiety, perceived threat and coping ability, as well as measures of dominance, valence, arousal. Cardiovascular reactivity was assessed via blood pressure and impedance cardiography. Results supported the hypothesis that social support provider anxiety resulted in less effective social support, and also indicated health costs of providing support under nonoptimal conditions.
An industrial hygiene field study of dental laboratories in the greater Salt Lake area.
Creators: name: Kimball, Anne Collier
Publisher: name: University of Utah
Year: 2012
Subjects: Hazardous Substances
Utah
Salt Lake County

description: An industrial hygiene study of thirteen dental laboratories in the greater Salt Lake area was performed in order to characterize the typical personal occupational exposures to hazardous substances in these workplaces.  Full-shift personal air samples were collected for nickel, chromium, cobalt, beryllium, and free silica during the grinding and polishing of non-precious metal and porcelain dental restorations.  Short-term personal and area samples for beryllium fumes were also taken during the metal casting process.  Personal samples were collected for methyl methacrylate vapors generated during the preparation of acrylic dentures.  The results of the air sampling were compared to the threshold limit values and permissible exposure levels for these substances.  Most of the air samples indicated low or non-detectable time-weighted average concentrations of the metals and free silica.  However, three high exposures to beryllium (>1.5 um-g/m3) and one high exposure to cobalt dust (>160 um-g/m3) were measured in two of the laboratories during the grinding and polishing of non-precious metal.  The samples taken during the casing process also indicated low or non-detectable levels of beryllium fumes.  Very low (<1.7 ppm) time-weighted average concentrations of methyl methacrylate were detected in the samples collected during the preparation of dentures.  Ventilation measurements were taken at these laboratories and recommendations have been made in consideration of the other factors that appear to affect exposure patterns in these workplaces. The potential for significant overexposures to hazardous substances in dental laboratories does exist; however, exposure levels to these materials apparently can be minimized with the utilization of proper ventilation design and work practices.
Additional file 2 of Semantic and cognitive tools to aid statistical science: replace confidence and significance by compatibility and surprise
Creators: name: Rafi, Zad
name: Greenland, Sander
Publisher: name: figshare
Year: 2020
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 2: Supplement. Technical issues in the interpretation of S-values and their relation to other information measures.
Assessment of intensive care unit nurses' knowledge of electrical safety: nursing implications
Creators: name: O'Brien, Susan Marian
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Safety
subject: Nursing
subject: FOS: Health sciences

description: Extended monitoring and treatment modalities for the critically ill patient have contributed significantly to nursing capability, while concurrently imposing increased nursing responsibility.  Nurses, as the primary uses of health care technology, need a comprehensive understanding of bioinstrumentation to provide safe, high level nursing care.  To date, no empirical demonstration of nurse's knowledge of electrical safety is found in the literature.  The purpose of this investigation was to document the level of electrical safety knowledge of a representative sample of Salt Lake City Intensive Care Unit nurses.  A research designed questionnaire was utilized to define the sample demographics, to test the level of electrical safety knowledge and to elicit the relationship of pertinent background variables with the percentage of correct answers in the electrical safety questionnaire.  Statistically, significant relationships were found between:  age with the percentage of correct answers in the electrical safety questionnaire, sex with percentage of correct responses in the electrical safety questionnaire and number of years as a Registered Nurse with percentage of accurate answers in the electrical safety questionnaire.  Descriptive statistical evaluation revealed that 63% of the sample answered less than 70% of the electrical safety questionnaire accurately.  This information led to the conclusion that this sample demonstrated an inadequate nursing knowledge that precludes the nurse's ability to recognize electrical hazards as actual electrical accidents.