cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hypothesis Testing of Varying Coefficient Regression Models: Procedures and Applications
Creators: name: Brooks, Robert D.
name: King, Maxwell L.
name: Brooks, Robert D.
name: King, Maxwell L.
Publisher: name: Unknown
Year: 1994
Subjects: subject: Research Methods/ Statistical Methods
subject: Hildreth-Houck random coefficients
subject: Lagrange multiplier tests
subject: point optimal tests
subject: small sample power
subject: return to normalcy random coefficients
subject: testing forward pricing models
subject: testing the market model

description: There is a considerable literature in econometrics on varying coefficient regression models. Some of the proposed models are simple and parsimonious. However given that even the simplest varying coefficient model is more complex than the constant coefficient model, researchers need to be able to test the adequacy of the constant coefficient simplification. This paper surveys the literature on testing for the presence of varying regression coefficients. We outline the wide variety of tests that have been proposed and look in detail at comparisons of the properties of different tests. In general, the literature indicates that tests that take into account the one-sided nature of the testing problem do best. Therefore tests such as point optimal tests and locally most mean powerful tests typically have superior power properties relative to other available tests. The paper concludes with a review of the application of this methodology in two areas of empirical finance. These involve testing the time constancy of systematic risk in the market model and testing the unbiased prediction hypothesis in forward and futures markets.
Caligus undulatus Shen and Li 1959
Creators: name: Venmathi Maran, B. A.
name: Ohtsuka, Susumu
name: Shang, Xu
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Maxillopoda
Siphonostomatoida
Caligidae
Caligus
Caligus undulatus

description: Caligus undulatus Shen and Li, 1959   (Fig. 8D, E)
 Caligus undulatus Shen and Li, 1959: 12; Yamaguti 1963: 60; Pillai 1966: 123; 1985: 360; Montú 1982: 329; Venmathi Maran and Ohtsuka 2008: 202; Nagasawa et al. 2010: 103.
 Material examined. Two adult ♀♀ (one ovigerous) (KMNH IvR 500,505) and one adult ♂ (KMNH IvR 500,506), Takamatsu Port, Kagawa Prefecture, Japan (St. 6), 3 October 2008 (Table 1).
 Description. Female. Body (Fig. 8D) 4.26, 4.29 mm long, excluding caudal setae. Cephalothoracic shield longer than wide, 2.02–2.05× 1.51–1.53 mm. Fourth pediger wider than long, 0.27–0.29× 0.37–0.39 mm. Genital complex longer than wide with irregular lateral margins, 1.21–1.23× 0.89–0.91mm. Abdomen long, 0.75–0.77× 0.31– 0.34 mm. Caudal ramus longer than wide, carrying 3 long terminal and 3 short subterminal setae.
 Male. Body (Fig. 8E) 3.54 mm long, excluding caudal setae. Cephalothoracic shield longer than wide, 1.89× 1.29 mm. Fourth pediger slightly constricted anteriorly. Genital complex longer than wide, 0.56× 0.39 mm. Abdomen distinctly 2-segmented, subequal in length and width. Caudal ramus as in female.
 Remarks. The present female specimens generally agree in size and morphology with those recently reported from plankton samples in Japan and Korea (Venmathi Maran and Ohtsuka 2008), but some discrepancies are observed between the present specimens and the specimen reported from China by Shen and Li (1959). The present female specimens lack prominent ridges on the genital complex, which are shown on the illustrations given by Shen and Li (1959), but not on specimens from India (Pillai 1966). The present male specimen (3.54 mm) is larger than one from China (3.08 mm) (Shen and Li 1959), but similar to others from India (3.50 mm) (Pillai 1966), Japan (3.50 mm), and Korea (3.52 mm) (Venmathi Maran and Ohtsuka 2008).
 Distribution. Caligus undulatus was originally discovered in plankton samples from China (Shen and Li 1959) and was subsequently found in Brazil (Montú 1982), India (Pillai 1966, 1985), Japan, and Korea (Nagasawa et al. 2010). This species has been found most frequently in plankton, and it may have unique aspects to its life history.
description: Published as part of Venmathi Maran, B. A., Ohtsuka, Susumu & Shang, Xu, 2012, Records of Adult Caligiform Copepods (Crustacea: Copepoda: Siphonostomatoida) in Marine Plankton from East Asia, Including Descriptions of Two New Species of Caligus (Caligidae), pp. 201-219 in Species Diversity 17 (2) on page 212, DOI: 10.12782/sd.17.2.201, http://zenodo.org/record/4649334
title: Characterization of a Cell Death Mechanism in a Mouse Model of Multiple Sulfatase Deficiency: Role of Mitochondrial Autophagy
Creators: name: De Pablo Latorre, Raquel
Publisher: name: The Open University
Year: 2011

description: Mitochondria are organelles recognized as central players in cell death. Dysfunctional mitochondria are a well-known hallmark of disease since the accumulation of aberrant mitochondria can alter cell homeostasis thus resulting in tissue degeneration. Lysosomal storage disorders (LSDs) are a group of genetic diseases characterized by the accumulation of un-degraded material inside lysosomes that leads to autophagic-lysosomal function failure. In LSDs, mitochondrial aberrations have been associated to autophagic stress. However, the mechanisms by which autophagic deregulation determines mitochondrial dysfunction and how such alterations are involved in tissue pathogenesis remain largely unexplored. Normally, mitochondrial clearance occurs by a selective form of autophagy, known as mitophagy, which relies on a parkin- mediated mitochondrial priming and subsequent engulfment by autophagosomes. Here, we have performed a comprehensive analysis of mitophagy in a mouse model of Multiple sulfatase deficiency (MSD), an LSD characterized by both severe neurological and systemic involvement. We demonstrated that, in MSD liver, reduced parkin results in an inefficient mitochondrial turnover thus determining the accumulation of effete organelles outside autophagic vesicles. As consequence, dysfunctional mitochondria release cytochrome c into the cytosol ultimately leading to apoptotic cell death. Otherwise, in MSD brain, we observed minor morphological and functional changes that could not be directly associated to specific defects in mitochondrial priming machinery. Together these data provide new evidences on the mechanisms underlying mitochondrial dysfunction in LSDs and indicate that mitochondrial alterations differently contribute to tissue pathogenesis in a mouse model of LSD.
One-Sided Hypothesis Testing in Econometrics: A Sruvey
Creators: name: Wu, Ping X.
name: King, Maxwell L.
name: Wu, Ping X.
name: King, Maxwell L.
Publisher: name: Unknown
Year: 1994
Subjects: subject: Research Methods/ Statistical Methods
subject: Kuhn-Tucker tests
subject: likelihood ratio tests
subject: linear regression
subject: locally best tests
subject: partially one-sided testing
subject: point optimal tests

description: Any model is accompanied by a set of assumptions. These assumptions are based either on the underlying theory of the phenomena being modelled or on stylized statistical evidence, or more commonly on both. These, along with functional considerations such as variances being positive, often imply that values of some parameters characterizing a model are restricted to one side of a point in the parameter space. This information can be used to improve the power of hypothesis testing procedures. In this paper, we discuss some recent developments on testing against such one-sided alternative hypotheses with particular emphasis on the econometrics literature. The focus is on two main approaches: that based on maximum likelihood estimation and that based on local power optimization facilitated by the generalized Neyman-Pearson lemma. Both single parameter and multi-parameter testing problems are considered.
Electronic structure of wurtzite quantum dots with cylindrical symmetry
Creators: name: Voon, L. C. Lew Yan
name: Galeriu, C.
name: Lassen, B.
name: Willatzen, M.
name: Melnik, R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: This paper presents a six-band k.p theory for wurtzite semiconductor nanostructures with cylindrical symmetry. Our work extends the formulation of Vahala and Sercel [Physical Review Letters 65, 239 (1990)] to the Rashba-Sheka-Pikus Hamiltonian for wurtzite semiconductors, without the need for the axial approximation. Results comparing our formulation for studying the electronic structure of wurzite quantum dots with the conventional formulation are given.
description: 11 pages, 3 figures
The Current State of DevSecOps Metrics
Creators: name: Nichols, William
Publisher: name: Carnegie Mellon University
Year: 2021
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: In the BBC documentary series 'Connections' technical innovations build on one another over time. New capabilities create new possibilities, new challenges, and new needs. This pattern also applies to the evolution of software engineering, where changes in software engineering practices are often driven by changes in underlying technologies. For example, the practice of frequent compiling and testing of code was a legacy of the post-punchcard era in the 1980s. When dedicated desktop compilers increased the convenience of compilation, it became easier for engineers to compile and test more frequently, which then became a common practice.
title: GDI-Mediated Cdc42 Recycling at Polar Cortex in Dynamic Maintenance of Cell Polarity in Saccharomyces cerevisiae
Creators: name: Das, Arupratan
Publisher: name: The Open University
Year: 2012

description: Cell polarization is a fundamental requirement for development and many physiological processes such as cell motility, stem cell differentiation, immune response and neuronal polarity. Small G-protein Rho GTPase, Cdc42 has long been shown to be the key regulator of the polarization process. In this study we aim to understand how cell maintains an optimum Cdc42 concentration at the polar cortex, and how distinct polarized Cdc42 distribution is achieved based on its recycling pathways taking budding yeast as a model system.

 Our in depth study revealed that Cdc42 at yeast polar cortex is dynamically maintained via two redundant pathways of distinct response time. A slow pathway dependent on actin-mediated endocytosis and exocytosis and a fast response pathway dependent on Rdil, yeast GDI (guanine dissociation inhibitor) for Rho GTPases. Quantitative imaging and mathematical modeling found both the pathways to be spatially overlapping in order to have physiological Cdc42 distribution. We further demonstrated Cdc42 GTPase cycle as the common regulator of actin and Rdil mediated pathways, a process supports their concentric localization.

 We further focused on gaining mechanistic insight of Rdil-mediated Cdc42 recycling at polar cortex. Using a high throughput genetic screen, imaging, spectroscopy and mathematical modeling we found that phospholipid asymmetry at the polar cortex regulated by lipid flippase complex (Lem3-Dnfl and Lem3-Dnf2) plays a key role in Rdil mediated fast dissociation of Cdc42 from the polar cortex. Our finding suggests that flipping of phosphatidylethanolamine (PE), a phospholipid with a positively charged head group, reduces the charge interaction between a Cdc42 C-terminal cationic region with the inner leaflet of the polar cortex, a key step for fast Rdil mediated Cdc42 extraction. In Δlem3 cells the negatively charged phospholipid phosphatidylserine (PS) is enriched in the inner leaflet of plasma membrane, as demonstrated by analysis of Cdc42 mutants with altered charge properties and biosensor for PS. Increase in PS in the inner leaflet increases Cdc42 and plasma membrane charge interaction antagonizing Rdil-mediated Cdc42 extraction. Using an in vitro assay with reconstituted supported lipid bilayers, we further demonstrated that relative composition of PE versus PS directly modulates the rate of Cdc42 extraction from the membrane by GDI.
Sacred Music and its Role in Shaping Worship Practices in the Christian Church
Creators: name: Yudika Sakti Lombu*
name: Aprinaldi Simorangkir
Publisher: name: Zenodo
Year: 2023
Subjects: Sacred music, shaping worship practices, christian church.

description: Abstract: This study explores the influential role of sacred music in shaping worship practices within the Christian church. Utilizing a mixed-methods approach, we combine historical analysis, survey data, and case studies to examine how musical elements have evolved and influenced liturgical structures across various Christian denominations. The research identifies sacred music as a significant vehicle for theological expression, community cohesion, and spiritual development. Additionally, the study investigates the dynamic interplay between traditional hymns and contemporary worship songs in modern church settings, revealing a balance between maintaining heritage and embracing innovation. The results demonstrate that sacred music functions not only as a form of worship but also as a means of theological reflection and community identity. These findings are particularly relevant for church leaders and music ministers, offering insights into how they can cultivate meaningful and engaging worship experiences by thoughtfully integrating diverse musical traditions. This research contributes to the broader understanding of sacred music’s essential role in Christian worship and its ongoing evolution in response to cultural and theological shifts.
An Investigation into Sustainable Lighting
Creators: name: Hetherington, Tayler
name: Marchuk, Bryan
name: Saputra, Hans
Publisher: name: The University of British Columbia
Year: 2010

description: Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”
Vorticity and Spin Polarization --- A Theoretical Perspective
Creators: name: Huang, Xu-Guang
Publisher: name: arXiv
Year: 2020
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We give a theoretical perspective on the vorticity and spin polarization in heavy-ion collisions. We discuss the recent progress in spin hydrodynamics and spin kinetic theory. We also discuss other effects caused by vorticity including the chiral vortical effect and rotation-induced phase transitions.
description: V1: 8 pages, 3 figures. For Quark Matter 2019
VIEWPOINT: SHORT AND LONG TERM PROSPECTS FOR SUGAR AND FORESTRY IN SOUTH AFRICA
Kort- en langtermyn vooruitsigte vir suiker en bosbou in Suid-Afrika
Creators: name: Ortmann, G. F.
name: Ortmann, G. F.
Publisher: name: Unknown
Year: 1991
Subjects: Crop Production/Industries
Environmental Economics and Policy

description: World sugar prices are at present falling and will affect domestic producers' profits detrimentally. Domestic consumers may not benefit from lower world prices because they have to buy A-pool sugar. Projections of sugar consumption over the long term suggest that aggregate consumption will increase roughly with population growth. Changes in domestic and international sugar policies could have a major impact on production and consumption trends. Timber prices are now declining after five years of shortages and rising prices. Domestic demand for timber is expected to increase by 2,7 per cent per year over the next 20 years. Average annual planting rates ranging from 20 000 ha to 35 000 ha have been recommended by forestry officials. Farmers (and companies) decide on a particular enterprise mix according to the expected relative profitability of enterprises and perceptions of risk.
Quenched and Unquenched Chiral Perturbation Theory in the ε-Regime
Creators: name: Damgaard, P. H.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The chiral limit of finite-volume QCD is the $ε$-regime of the theory. We discuss how this regime can be used for determining low-energy observables of QCD by means of comparisons between lattice simulations and quenched and unquenched chiral perturbation theory. The quenched theory suffers in the $ε$-regime from ``quenched finite volume logs'', the finite-volume analogs of quenched chiral logs.
description: LaTeX, 7 pages, contribution to LHP2003
t$|$ket$\rangle$ : A Retargetable Compiler for NISQ Devices
Creators: name: Sivarajah, Seyon
name: Dilkes, Silas
name: Cowtan, Alexander
name: Simmons, Will
name: Edgington, Alec
name: Duncan, Ross
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present t$|$ket$\rangle$, a quantum software development platform produced by Cambridge Quantum Computing Ltd. The heart of t$|$ket$\rangle$ is a language-agnostic optimising compiler designed to generate code for a variety of NISQ devices, which has several features designed to minimise the influence of device error. The compiler has been extensively benchmarked and outperforms most competitors in terms of circuit optimisation and qubit routing.
description: 43 pages. Submitted
title: Aripiprazole, Olanzapine and Haloperidol in the Long-Term Treatment of Schizophrenia: The Rationale and Development of the GiSAS Pragmatic Randomized Controlled Trial, a Consideration and Empirical Study of Factors Associated With Recruitment (the GiSAS Survey) and the Concept of Endpoints Using a Secondary Analysis of Existing Data and a Preliminary Analysis of GiSAS Trial Data
Creators: name: Parabiaghi, Alberto
Publisher: name: The Open University
Year: 2012

description: This thesis described the development of a pragmatic, randomized clinical trial evaluating the safety and efficacy of antipsychotic treatment in schizophrenia. In the perspective of highlighting some critical issues of the trial design, the thesis focused on the trial's planning and conduct and on the preliminary analysis of the first followed-up subjects. Having experienced significant problems in patient recruitment a survey on perceived inclusion barriers and antipsychotic preference was performed. Investigators mainly complained about system-related barriers, and believed in the superiority of second-generation antipsychotics. Taking the cue from these results, strategies were adopted in order to reach the planned target of 800 subjects. Remedial actions included study promotion activities, education initiatives and bursaries, and resulted in a significant improvement of the recruitment rate. Nevertheless, we had to reduce the sample to one third of the original size. The second part of the thesis focused on the concept of endpoints using a secondary analysis of existing data and a preliminary analysis of GiSAS trial data. The assumption that differences in discontinuation rates reflect differences in effectiveness was reinforced by the results of a pharmaco-epidemiological study comparing the use of reboxetine and SSRIs in a large population sample. The established lack of efficacy of this antidepressant was mirrored by a higher proportion of treatment discontinuations. We explored the baseline characteristics of 114 included subjects and compared the baseline and follow-up variables between those who discontinued study drugs at follow-up and those who did not. Discontinues' worse outcome was mainly attributable to self reported side-effects. This thesis highlighted some critical issues on the execution of a pragmatic trial in schizophrenia. The feasibility of the trial design and the concept of endpoints were critically analyzed. The trial mechanism is now fully functional and most problems of its implementation have been identified and contained.
Cosmic ray feedback from supernovae in dwarf galaxies
Creators: name: Dashyan, Gohar
name: Dubois, Yohan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The regulation of the baryonic content in dwarf galaxies is a long-standing problem. Supernovae (SNe) are supposed to play a key role in forming large-scale galactic winds by removing important amounts of gas from galaxies. SNe are efficient accelerators of non-thermal particles, so-called cosmic rays (CRs), which can substantially modify the dynamics of the gas and conditions to form large-scale galactic winds. We investigate how CR injection by SNe impacts the star formation and the formation of large-scale winds in dwarf galaxies, and whether it can produce galaxy star-formation rates (SFR) and wind properties closer to observations. We ran CR magneto-hydrodynamical simulations of dwarf galaxies at high resolution (9 pc) with the adaptive mesh refinement code ramses. Disc galaxies are embedded in isolated halos of mass of $10^{10}$ and $10^{11} \, \rm M_{\odot}$, and CRs are injected by SNe. We included CR isotropic and anisotropic diffusion with various diffusion coefficients, CR radiative losses, and CR streaming. The injection of CR energy into the interstellar medium smooths out the highest gas densities, which reduces the SFR by a factor of 2-3. Mass outflow rates are significantly greater with CR diffusion, by 2 orders of magnitudes for the higher diffusion coefficients. Without diffusion and streaming, CRs are inefficient at generating winds. CR streaming alone allows for the formation of winds but which are too weak to match observations. The formation of galactic winds strongly depends on the diffusion coefficient: for low coefficients, CR energy stays confined in high density regions where CR energy losses are highest, and higher coefficients, which allow for a more efficient leaking of CRs out of dense gas, produce stronger winds. CR diffusion leads to colder and denser winds than without CRs, and brings outflow rates and mass loading factors much closer to observations.
description: 19 pages, 15 figures, A&A accepted
Evolution of planetary nebulae II. Population effects on the bright cut-off of the PNLF
Creators: name: Marigo, P.
name: Girardi, L.
name: Weiss, A.
name: Groenewegen, M. A. T.
name: Chiosi, C.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the bright cut-off of the [OIII]l5007 planetary nebula luminosity function (PNLF), that has been suggested as a powerful extragalactic distance indicator. Theoretical PNLFs are constructed via Monte-Carlo simulations of populations of PNe, whose individual properties are described with the aid of recent PN synthetic models (Marigo et al. 2001), coupled to a detailed photoionisation code (CLOUDY). The basic dependences of the cut-off magnitude M* are then discussed. We find that: (i) In galaxies with recent or ongoing star formation, the modelled PNLF present M* values between -4 and -5, very close to the observationally-calibrated value for the LMC. (ii) In these galaxies, the PNLF cut-off is produced by PNe with progenitor masses of about 2.5 Msun, while less massive stars give origin to fainter PNe. As a consequence M* is expected to depend strongly on the age of the last burst of star formation, dimming by as much as 5 mag as we go from young to 10-Gyr old populations. (iii) Rather than on the initial metallicity of a stellar population, M* depends on the actual [O/H] of the observed PNe, a quantity that may differ significantly from the initial value (due to dredge-up episodes), especially in young and intermediate-age PN populations. (iv) Also the transition time from the end of AGB to the PN phase, and the nuclear-burning properties (i.e. H- or He-burning) of the central stars introduce non-negligible effects on M*. The strongest indication derived from the present calculations is a serious difficulty to explain the age-invariance of the cut-off brightness over an extended interval, say from 1 to 13 Gyr, that observations of PNLFs in galaxies of late-to-early type seem to suggest.
description: 22 pages, to appear in Astronomy & Astrophysics
Datasets for fig3 A multi-resistance wide-range calibration sample for conductive probe atomic force microscopy measurements
Creators: name: Piquemal, François
Publisher: name: Zenodo
Year: 2024

description: The dataset corresponds to the figure 3 of the paper "Multi-Resistance Wide-Range Calibration Sample for Conductive probe Atomic Force Microscopy Measurements"

with DOI: 10.3762/bjnano.14.94
Nonequilibrium statistical mechanics of swarms of driven particles
Creators: name: Ebeling, Werner
name: Erdmann, Udo
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: As a rough model for the collective motions of cells and organisms we develop here the statistical mechanics of swarms of self-propelled particles. Our approach is closely related to the recently developed theory of active Brownian motion and the theory of canonical-dissipative systems. Free motion and motion of a swarms confined in an external field is studied. Briefly the case of particles confined on a ring and interacting by repulsive forces is studied. In more detail we investigate self-confinement by Morse-type attracting forces. We begin with pairs N = 2; the attractors and distribution functions are discussed, then the case N > 2 is discussed. Simulations for several dynamical modes of swarms of active Brownian particles interacting by Morse forces are presented. In particular we study rotations, drift, fluctuations of shape and cluster formation.
description: 11 pages, 2 figures
title: The TRIM (TRipartite Motif) Family as a Novel Class of Ubiquitin E3 Ligases
Creators: name: Napolitano, Luisa Maria Rosaria
Publisher: name: The Open University
Year: 2011

description: Proteins that belong to TRIM family are characterized by the presence of the tripartite motif module, composed of a RING domain, one or two B-box domains and a Coiled-coil region. TRIM proteins are involved in several cellular processes such as apoptosis, cell cycle regulation and viral response. The aim of my project was to study the involvement of TRIM proteins in the ubiquitylation process, a versatile post-translational modification mechanism used by eukaryotic cells mainly to control proteins levels through proteasome-mediated proteolysis. In particular, the presence of the RING domain and experimental data suggested a possible TRIM role as Ubiquitin Ligases (E3), the component of the ubiquitylation cascade responsible for the transfer of Ubiquitin to the specific target. A condition for being an E3 is the interaction with another component of the ubiquitylation cascade, the Ubiquitin Conjugating Enzymes (UBE2). Therefore, I tested the interaction between 26 UBE2 enzymes and 42 TRIM proteins. I observed that the majority of the TRIM proteins tested interact with UBE2 enzymes and I also found a general preference of the TRIM proteins for the D and E classes. Two important exceptions were observed: TRIM9-UBE2G2 and TRIM32-UBE2V1/2 specific interactions. Furthermore, representative interactions were confirmed and I also demonstrated that the TRIM E3 activity is only manifest with the UBE2 they interact with. For most specific interactions I could also observe subcellular co-localisation of the TRIM involved and its cognate UBE2 enzyme suggesting that the specific selection of TRIM-UBE2 pairs has physiological relevance. In addition I found that almost all TRIM proteins tested interacted with UBE2I that is the specific E2 enzyme involved in modification with SUMO, a Ubiquitin-like peptide. Consistently, representative interactions were confirmed and for a subset of TRIM proteins I demonstrated the involvement in the SUMOylation pathway suggesting a possible cross-talk between ubiquitylation and SUMOylation.
An Investigation into the Utensils to be used for the New Student Union Building for the Purpose of Sustainability
Creators: name: Pang, Anthony
name: Yang, Peter
name: Thorpe, Ryan
name: Leslie, Ian
Publisher: name: The University of British Columbia
Year: 2010

description: Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”
title: Investigating the Behavioural and Molecular Functions of Cry1 and Cry2 Using Mouse Mutants
Creators: name: Anand, Sneha Nitish
Publisher: name: The Open University
Year: 2012

description: Endogenous circadian clocks generate rhythms of physiology and behaviour that are synchronised to the environment, principally through the light-dark cycle. In mammals, the circadian clock is dependent on interlocked feedback loops that involve several clock elements such as cryptochromes (Cry1 and Cry2). Post-translational modifications control intracellular trafficking, functionality and degradation of CRY proteins which are keys to the functioning of the clock. CRY protein levels are dependent upon their timely degradation by F-box proteins. This has recently been shown in the afterhours (Afh) mutant carrying a mutation in the F-box gene, Fbxl3. Afh has been shown to lengthen circadian period by stabilising levels of CRY proteins across the circadian cycle. To understand the specific roles of each of the two CRY proteins in circadian regulation, we generated compound mouse mutants to investigate the behavioural and molecular consequences of stabilising either CRY1 or CRY2 protein levels in mice lacking the alternative form of Cry. The circadian wheel-running activity assessed in light:dark and constant environmental conditions for both Cry1-/-;Fbx13Afh/Afh and Cry2-/-;Fbx13Afh/Afh (stabilising CRY2 and CRY1 protein levels respectively); clearly show a gradual increase in period length in constant darkness as the dosage of Fbxl3Afh is increased. This would suggest that stabilisation of either CRY protein can lengthen the clock, presumably as a result of a prolonged phase of transcriptional repression by either protein. This effect seen in the compound mutants was confirmed at the gene and protein levels and it was concluded that Cry1 and Cry2 can both act as transcriptional repressors, but that Cry1 plays the predominant inhibitory role in the cerebellum and peripheral organs.

Subsequently it has been shown that FBXL21, the closest homologue of FBXL3, also binds to CRY1 and impairs its repressive action towards the transcriptional activators, CLOCK-BMAL1 presumably by degrading CRY1. Due to differences in their expression Fbxl3 and Fbxl21 may have overlapping roles. In-vitro and in vivo analysis in mutants generated in Fbxl21; revealed CRY2 as a preferable target of FBXL21 and that this may contribute to the lower repressive function of Cry2. Further investigation into the genetic interactions between the two F-box genes showed that Fbxl3 is epistatic to Fbxl21.

Finally, Fbxl21 has been shown to be associated with schizophrenia in humans. In our hands mutant mouse Fbxl21 showed no such associations, instead indicating an association with anxiety and/or defects in sensorimotor gating.
Speciational view of macroevolution: are micro and macroevolution decoupled?
Creators: name: Schwammle, V.
name: Brigatti, E.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: We introduce a simple computational model that, with a microscopic dynamics driven by natural selection and mutation alone, allows the description of true speciation events. A statistical analysis of the so generated evolutionary tree captures realistic features showing power laws for frequency distributions in time and size. Albeit these successful predictions, the difficulty in obtaining punctuated dynamics with mass extinctions suggests the necessity of decoupling micro and macro-evolutionary mechanisms in agreement with some ideas of Gould's and Eldredge's theory of punctuated equilibrium.
description: Europhys. Lett. 75:342--348
Evidence That Paleolithic Hominins Lived in Close Association With Weaverbirds and Their Basket Making Skills
Creators: name: Doble, Rick
Publisher: name: figshare
Year: 2020
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: 210102 Archaeological Science
subject: FOS: History and archaeology
subject: 210199 Archaeology not elsewhere classified
subject: 219999 History and Archaeology not elsewhere classified
subject: Paleontology

description: The purpose of this article is simple. I argue that early hominins, almost two million years ago, lived in close proximity to Weaverbirds who built elaborate nests. And because of this, it is probable that they learned initial weaving and knot making skills along with basket making, derived from the complex and well-constructed nests of these birds.
If this is true, then the origins of basket making and weaving began almost two million years ago instead of tens of thousands of years ago, as is currently believed. And this fundamentally changes the story of hominin technology which in turn affects the narrative of human evolution.
In this article, I cite specific scientific evidence, current mainstream thought and expert opinions to make my case.
Standardization landscape and applicable standards
Creators: name: Miguel Angel, Aranda Gomez
Publisher: name: Zenodo
Year: 2021
Subjects: subject: Open Innovation Test Bed
subject: OITB
subject: Biomaterials
subject: Nanomaterials
subject: Standardization
subject: Nanotechnology
subject: FOS: Nanotechnology
subject: Nanocellulose
subject: Bioplastic
subject: Natural Fibres

description: INN-PRESSME aims at developing and implementing a sustainable OITB to support European companies to scale up their nano-enabled biomaterials and processes from TRL 4-5 to 7. It will focus on (nano)cellulose, bioplastics and natural fibres, combined with nanotechnology approaches to tailor bio-based materials with properties and functionalities (barrier, antibacterial properties, improved corrosion or chemical resistance, etc.) that equal or outperform their fossil counterparts at competitive prices. INNPRESSME gathers 16 pilot lines, organized in routes and processes for feedstock conversion (PLA, PHA, fibre-based, cellulose-based), formulation and transformation and processing of bio-based material to high added-value products.Standardization is certainly a tool that can support the project to facilitate scaling-up the products covered by this project and could also be a way to contribute to expand the results of INN-PRESSME by providing a summary of best practices or guidance on OITB services. The way that the role of standards in the project is structured responds to three stages:- Analysis of the existing standards and ongoing works identifying possible relations between INN-PRESSME activities and this selection of standards and works. The organizations, technical bodies or groups, where the works are developed, are to be also identified.- Contact the identified entities, where standards or works exist, to explain INN-PRESSME project trying to raise awareness and opening ways to further collaboration in view of the progress and results of INN-PRESSME.- Prepare and perform a contribution to standardization based on INN-PRESSME results looking to the higher possible impact into standardization.In this aim, this deliverable summarizes the existing standardization landscape, including the standards and ongoing projects, the technical bodies where these documents are developed and maintained and serves as the basis for next steps such us raising awareness of INN-PRESSME results to these bodies.
SOLVING STOCHASTIC SADDLEPOINT SYSTEMS: A QUALITATIVE TREATMENT WITH ECONOMIC APPLICATIONS
Creators: name: Miller, Marcus
name: Weller, Paul
name: Miller, Marcus
name: Weller, Paul
Publisher: name: Unknown
Year: 1988
Subjects: Financial Economics
Research Methods/ Statistical Methods

description: We examine the effect of introducing stochastic shocks into a linear rational expectations model with saddlepoint dynamics generated by a forward-looking asset price. We derive the fundamental differential equation governing the path of the asset price as a function of the "sluggish" variable. The equation does not admit of closed form solutions in general, but we provide a complete qualitative characterization of the solution paths which are symmetric about equilibrium. These are the relevant solutions to consider in the presence of symmetric boundary conditions. We present two applications. The first analyzes how financial markets might react to the implementation of fiscal stabilization policy where public expenditures are only adjusted when GNP moves outside a threshold around a target level. Bond prices are perfectly flexible and move to satisfy an arbitrage condition. The second examines exchange rate behavior in the presence of a currency subject to a known realignment rule requiring an adjustment to monetary policy.
X-ray triple rings around the M87 jets in the central Virgo cluster
Creators: name: Feng, Hua
name: Zhang, Shuang-Nan
name: Lou, Yu-Qing
name: Li, Ti-Pei
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Chandra X-ray data of the central Virgo cluster are re-examined to reveal a triple-ring structure around the galaxy M87, reminiscent of the spectacular triple-ring pattern of the SN1987A in the Large Magellanic Cloud (LMC). In the sky plane, the two apparent smaller ellipses are roughly aligned along the M87 jets; the larger ring centers at the M87 nucleus and is likely a circle roughly perpendicular to the M87 jet. Certain similarities of these two triple-ring structures might hint at similar processes that operate in these two systems with entirely different sizes and mass scales. We suspect that a major merging event of two galaxies with nuclear supermassive black holes (SMBHs) might create such a triple-ring structure and drove acoustic and internal gravity waves far and near. The M87 jets are perhaps powered by a spinning SMBH resulting from this catastrophic merging event.
description: accepted by ApJL
EXCHANGE RATE BANDS AND REALIGNMENTS IN A STATIONARY STOCHASTIC SETTING
Creators: name: Miller, Marcus
name: Weller, Paul
name: Miller, Marcus
name: Weller, Paul
Publisher: name: Unknown
Year: 1988
Subjects: subject: Financial Economics
subject: International Relations/Trade
subject: Exchange Rate Bands
subject: Realignments
subject: EMS

description: The extent to which exchange rate management can coexist with an independent monetary policy is examined in the context of a model with exchange rate bands. Using a Dornbusch model in which stochastic stocks are added to the Phillips curve, we analyse the implications of assuming that the monetary authorities follow certain simple rules for realigning the band when fundamentals have drifted too far from equilibrium. Assuming that information about whether the band is to be defended or there is to be a realignment is revealed at the point when the exchange rate hits the edge of the band, we show how the path of the exchange rate can be completely characterised in terms of solution to a second order non linear differential equation -- together with jumps in the rate at the edge of the band, which satisfy a zero-profit arbitrage condition. When the realignment is expected with certainty, hysteresis is introduced into the behaviour of the exchange rate
Towards fidelity and scalability in non-vacuum mergers
Creators: name: Liebling, S. L.
name: Palenzuela, C.
name: Lehner, L.
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the evolution of two fiducial configurations for binary neutron stars using two different general relativistic hydrodynamics(GRHD), distributed adaptive mesh codes. One code, HAD, has for many years been used to study mergers of compact object binaries, while a new code, MHDuet, has been recently developed with the experience gained with the older one as well as several novel features for scalability improvements. As such, we examine the performance of each, placing particular focus on future requirements for the extraction of gravitational wave signatures of non-vacuum binaries.
description: 10 pages, 8 figures
CFD_D3.1_WP3_Demo design guide_TEAGASC_30.06.2023
Creators: name: Teagasc - The Irish Agriculture and Food Development Authority
Publisher: name: Zenodo
Year: 2024
Subjects: Demonstration

description: This deliverable focuses on the design, delivery, and evaluation of climate-smart farming demonstration events, including the provision of an inventory of recognized farm demo activities. This guide outlines potential demonstration approaches (including for on-farm, virtual, and hybrid events), the multi-actor approach to farm demos, the use of GHG toolkits, and the demonstration of carbon farming opportunities. It is very well thought out.
Surface Analysis of OFE-Copper X-Band Accelerating Structures and Possible Correlation to RF Breakdown Events
Creators: name: Harvey, S. E.
name: Pimpec, F. Le
name: Kirby, R. E.
name: Marcelja, F.
name: Adamson, K.
name: Garwin, E. L.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: X-band accelerator structures meeting the Next Linear Collider (NLC) design requirements have been found to suffer vacuum surface damage caused by radio frequency (RF) breakdown, when processed to high electric-field gradients. Improved understanding of these breakdown events is desirable for the development of structure designs, fabrication procedures, and processing techniques that minimize structure damage. RF reflected wave analysis and acoustic sensor pickup have provided breakdowns localization in RF structures. Particle contaminations found following clean autopsy of four RF-processed travelling wave structures, have been catalogued and analyzed. Their influence on RF breakdown, as well as that of several other material-based properties, will be discussed.
description: 21 pages, 8 figures, 4 tables, Submitted to JVST A as a proceeding of the 50th AVS conference (Baltimore, MD, 2-7 Nov 2003)
title: Perceptions of the Social and Cultural Factors Which Have Influenced the Use of Dialect in Orkney
Creators: name: Rendall, Thomas
Publisher: name: The Open University
Year: 2013

description: This thesis examines the social and cultural factors which have influenced the use of dialect in Orkney. Orcadians could be said to be bi-dialectal speaking an Orcadian-influenced Scottish Standard English including Norse-derived lexical items spoken within a diglossic speech situation. The main factors on which the research questions were based featured the effects of migration on the language and dialect of the islands; the attitudes of the local population on the use of dialect in a variety of situations; the consequences of greater demographic movement within Orkney and how this might have shaped the way people interact within the community. Through interviews with people from 13 different locations along with the completion of 100 questionnaires, a comprehensive range of information has been gathered. The thesis provides a contribution to the literature on the use of dialect in Orkney in an area which has hitherto been generally overlooked and certainly not covered from a social and cultural perspective.
title: Pourquoi les femmes occupent-elles moins de postes à responsabilité ? Une analyse des promotions universitaires en économie (Policy Brief, n°14)
Creators: name: Bosquet, Clément
name: Combes, Pierre-Philippe
name: Garcia-Penalosa, Cecilia
Publisher: name: Sciences Po - LIEPP
Year: 2014
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Si les écarts entre les hommes et les femmes de taux d'emploi global et de salaires, à caractéristiques observables données, dont le type d'emploi, sont devenus très faibles, il n'en reste pas moins que les femmes occupent moins fréquemment des postes à haute responsabilité, mieux rémunérés. Notre étude sur le monde académique français en sciences économiques montre que les femmes ne sont pas discriminées lors des concours de promotion mais qu'elles postulent de 30 à 40% moins que les hommes à ces concours. Nous montrons également que cette différence n'est pas due à un coût à passer les concours plus élevé pour elles ou à une plus grande réticence à quitter des universités prestigieuses pour être promues. Les femmes postuleraient moins soit par anticipation d'une discrimination, soit par manque de confiance. Au-delà d'actions de long-terme, dès l'enfance, sur la confiance en soi visant à rendre les femmes plus enclines à "entrer en compétition'', rendre publics ces écarts de candidatures et de promotion (pour changer les anticipations de discrimination) et rendre automatiques les candidatures pourraient constituer des solutions pour réduire les écarts entre les hommes et les femmes de candidature à la promotion.
description: Gender gaps in employment and wages have decreased over the past decades, especially once we control for observable characteristics. However, women are still underrepresented in high paid jobs, and this is largely the result of lower promotion rates. Our study on French academic economists, whose promotion to senior positions occurs through a national contest, finds that women are not subject to discrimination during the promotion contests. Instead, female academics are between 30 and 40% less likely than men to enter these contests. We also find that this application gap is not due to a higher cost of promotion for women nor to women having a different trade-off between wages and department prestige than men, which leaves the expectation of discrimination and a dislike for entering competitions as the sole possible explanations. Long-term public policy can aim at encouraging self-confidence in girls so as to eventually make women as competitive as men. In the short term, making the application gap public knowledge so as to change women’s expectations of discrimination or making candidatures automatic, substituting the opting-in by an opting-out system, could reduce the gender gap in promotions.
JISMONIY SHAXSLARDAN OLINADIGAN DAROMAD SOLIĢ'I
Creators: name: Saydullayeva, Gulshan
Publisher: name: Zenodo
Year: 2025

description: Mazkur  maqolada  O‘zbekiston  Respublikasining  soliq qonunchiligiga  ko‘ra  jismoniy shаxslardan olinadigan daromad solig‘i tarkibi, jismoniy shaxslardan olinadigan daromad solig‘i mexanizmini takomillashtirishda xorijiy mamlakatlarning ilg‘or tajribalari, jumladan, Fransiya soliq tizimida soliq to‘lovchilar daromadi kategoriyalari, AQSH soliq tizimi, Yaponiyada jismoniy shaxslar daromad solig‘i stavkalari, rivojlangan mamlakatlarda jismoniy shaxslardan olinadigan daromad solig‘ining budjet daromadlari tarkibida yetakchi o‘rin egallashidagi sabablari ko‘rib o‘tilgan. Shuningdek, iqtisodchi olimlarning tadqiqotlari o‘rganilgan va ilmiy qarashlari  ochib