cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Studies on the Expression and Phosphorylation of the USP4 Deubiquitinating Enzyme
Creators: name: Bastarache, Sophie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: USP4
Ubiquitin
Proteasome
B-catenin
Wnt signaling
GRK2

description: The USP4 is a deubiquitinating enzyme found elevated in certain human lung and adrenal tumours. USP4 has a very close relative, USP15, which has caused great difficulty in studying only one or the other. We have had generated two antibodies specific to USP4 and USP15, and have confirmed that the two do not cross react. Although there have been previous findings of interacting partners, possible substrates and pathways in which it is involved, the biological role of USP4 is mostly unknown. We have used these antibodies to determine that USP4 and USP15 expression differs across tissue and cell types, and that expression changes as the organism ages. We have shown that USP4 plays a role in canonical Wnt signaling, perhaps by stabilizing Beta-catenin, and identified GRK2 as a kinase, phosphorylating USP4. These data have provided enough information to form a hypothesis, implicating USP4 with the destruction complex in the Wnt signaling pathway.
Investigating the Inclusion of Ethno-depoliticization within Peace-building Policies in Post-conflict Sierra Leone
Creators: name: Cole, Matilda
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Ethno-politicization
Ethno-politics
Ethno-Depoliticization
Peace
Peace-Building
Peace-Building Policies and Ethno-depoliticization
Peace-Building and Instrumentalism
Sierra Leone Politics and Instrumentalism
Conflict

description: Ethno-politicization has been identified as a covert yet pervasive contributing factor in the various outbreaks of violence throughout Sierra Leone’s post-independence history. With the latest round of violent conflict having ended in 2002, the government of Sierra Leone in collaboration with local and international partners is presently engaged in peace-building. That being said, institutionalized peace-building has a considerable but imperfect track record of success. Furthermore, the intricate way in which ethno-politicization is woven into the social-political fabric of Sierra Leone is such that, if not effectively treated, it poses a continuing threat to the stability of the nation. Accordingly this thesis examined the extent to which ethno-depoliticization strategies have been directly incorporated into the peace-building framework. This task was accomplished through the development of a five-point definition of ethno-politicization that is based on the institutional instrumentalist theory. The definition provided an analytical framework used in the interpretation of results from a policy audit and field interviews with representatives of the peace-building architects. The research revealed that within the peace-building framework, ethno-politicization is not directly acknowledged as a real and ongoing threat to peace and stability and hence, a prioritized component of the peace-building architecture. However, some of the policy initiatives contained within the peace-building framework will indirectly result in ethno-depoliticization outcomes. These policy initiatives nevertheless require more rigorous and focused implementation and monitoring to be effective. Accordingly, the study recommends (i) the implementation of the recommendations of the Truth and Reconciliation Commission (ii) a constitutional amendment stipulating ethnic quotas for political party leadership and parliamentary candidates; (iii) the strengthening of civil society;(iv) an intensive nation-wide campaign promoting a national identity and; (v) the strengthening of democratic institutions, which also includes making ethnically-inclusive and ethnically impartial practices within public institutions as part of the performance evaluation of senior public servants.
Hubble, Webb and the search for First Light galaxies
Creators: name: Glazebrook, Karl
Publisher: name: Swinburne
Year: 2024

description: When the Obama administration announced its proposed NASA budget in February, astronomers worldwide breathed a sigh of relief. Despite significant cuts in other areas, funding for the James Webb Space Telescope had been maintained. Building and installing the telescope is going to cost US$8 billion – a lot of money for a single scientific facility. The project has also been plagued by considerable delays for the best part of a decade and was even slated for cancellation last year. So why did astronomers fight so hard to get the project back on track? Quite simply, it is the successor to one of the most successful scientific facilities ever built - the Hubble Space Telescope.
The Clinical Validity of Family History in Risk Classification of Colorectal Cancer
Creators: name: Jonah, Leigh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Family History
Colorectal Cancer
Risk Classification

description: Objective: To determine the clinical validity of family history (FH) in colorectal cancer (CRC) risk classification. Methods: The Assessment of Risk of Colon Tumors In Canada case-control dataset was used to develop regression models associating risk factors with CRC in Ontario adults. Two regression models (‘clinically-driven’ based on a previously published tool, and data-driven) examined discrimination between CRC cases and controls, with and without the inclusion of FH as a risk variable. Discrimination was assessed using the area under the receiver operator characteristics curve. Results: For males, with the addition of FH, there were statistically significant yet quantitatively modest improvements in both models (3.7% clinically-driven, 6.8% data-driven). For females, while FH was a statistically significant predictor of CRC status in the data-driven model, the improvement in discrimination was not significant in either model. Conclusion: FH provides very small improvement in model discrimination beyond other standard CRC risk factors.
Estonian scientist in USSR (Memories and reflections about Endel Lippmaa, 1930 -2015)
Creators: name: Kessenikh, Alexander
Publisher: name: Substantia
Year: 2020

description: Endel Lippmaa - Estonian physicist and chemist was one of the pioneers in the development and application of NMR method (1950s - 1970s). He had to work in conditions when Estonia was part of the USSR as the Estonian SSR and, nevertheless, the development of science in the republic was not interrupted. He later became an academician and vice-president of the Academy of Sciences of the Estonian SSR. The important role of Lippmaa in the development of nuclear magnetic resonance and other areas of chemical physics in Estonia, the USSR, and around the world is considered. The article also contains the reminiscences considering personal contacts with Lippmaa of the famous Russian chemist Yu.A. Ustynyuk. In 1994 Lippmaa was awarded the AMPERE Prize for original research in high-resolution NMR of solid-state. Perhaps in more favorable conditions, in contact with other eminent scientists who worked abroad, he would have achieved even greater results, but such contacts were during a long time impossible for him.
description: Substantia, Vol. 4 No. 2 (2020)
Kunststoffe in Böden
Creators: name: Biegel-Engler, Annegret
name: Schneider, Isger
name: Eichler, Philipp
name: Hermann, Tim
name: Krüger, Franziska
name: Keßler, Hermann
name: Weißhaupt, Petra
name: Sättler, Daniel
name: Braun, Ulrike
name: Scholz, Katrin-Nannette
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Kunststoff
subject: Boden
subject: Quellen
subject: FuE-Bedarf
subject: Kunststoffe
subject: Plastik
subject: boden
subject: Forschungsbedarf
subject: handlungsbedarf
subject: Boden | Fläche

description: Kunststoffe sind vielseitig einsetzbar und erleichtern uns das Leben in vielen Bereichen. Zum Problem können Kunststoffe werden, wenn sie in die Umwelt gelangen und dort von Organismen aufgenommen und in die Ökosysteme eingetragen werden. Folgen der Verunreinigungen mit großen Kunststoffteilen wie Plastiktüten sind offensichtlich, doch auch das kaum sichtbare Mikroplastik birgt Risiken für die Umwelt und die menschliche Gesundheit. Denn einmal in die Umwelt eingetragen, kann Mikroplastik kaum zurückgeholt werden. Der vorliegende Bericht zeigt den Sachstand zum Vorkommen von Kunststoffen in Böden, erläutert die Folgen für die Böden, angrenzenden Medien, Pflanzen und Menschen. Er benennt bereits laufende Maßnahmen, um Kunststoffeinträge in die Böden wirksam zu reduzieren. Darüber hinaus adressiert er, neben dem Forschungsbedarf, den notwendigen weiteren Handlungsbedarf. Quelle: https://www.umweltbundesamt.de/
description: Kunststoffe sind vielseitig einsetzbar und erleichtern uns das Leben in vielen Bereichen. Zum Problem können Kunststoffe werden, wenn sie in die Umwelt gelangen und dort von Organismen aufgenommen und in die Ökosysteme eingetragen werden. Folgen der Verunreinigungen mit großen Kunststoffteilen wie Plastiktüten sind offensichtlich, doch auch das kaum sichtbare Mikroplastik birgt Risiken für die Umwelt und die menschliche Gesundheit. Denn einmal in die Umwelt eingetragen, kann Mikroplastik kaum zurückgeholt werden.Der vorliegende Bericht zeigt den Sachstand zum Vorkommen von Kunststoffen in Böden, erläutert die Folgen für die Böden, angrenzenden Medien, Pflanzen und Menschen. Er benennt bereits laufende Maßnahmen, um Kunststoffeinträge in die Böden wirksam zu reduzieren. Darüber hinaus adressiert er, neben dem Forschungsbedarf, den notwendigen weiteren Handlungsbedarf.
The Strange Case of Professor Promezio: A Cold Case in the Chemistry Museum
Creators: name: Basso, Andrea
name: Alloisio, Marina
name: Carnasciali, Maria Maddalena
name: Grotti, Marco
name: Vicini, Silvia
Publisher: name: Substantia
Year: 2020

description: Promezio is a famous Italian chemistry professor who is searching for missing element n. 61. In 1924 his laboratory is partially destroyed by a fire and he disappears. Almost one hundred years later high school students are recruited to investigate this strange case. “The strange case of Professor Promezio” represents a unicum in the panorama of laboratory activities for high school students: it is a cold case in which students are asked to investigate a fact that took place almost a century ago. Through the chemical analysis of different findings, the connection with historical events of that period, the study of the suspects' interrogation reports, the reproduction of the experiments conducted by Professor Promezio, the students will identify the possible culprit. A complex scientific problem is solved exploring different areas of chemistry and, in addition, interconnections with history, geography, ethics and other school subjects are deepened.
description: Substantia, Vol. 4 No. 2 (2020)
Supplementary document for Influence of the bus waveguide on the linear and nonlinear response of a taiji microresonator - 5383451.pdf
Creators: name: Franchi, Riccardo
name: Biasi, Stefano
name: de las Heras, Alberto Muñoz
name: Ghulinyan, Mher
name: Carusotto, Iacopo
name: Pavesi, Lorenzo
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental Document 1
Thermal expansion of the noble metals below 15°K.
Creators: name: Kos, Joseph F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1967
Subjects: subject: Physics, Atomic.

description: A dilatometer of exceptionally high sensitivity has been developed and used to measure the thermal expansion of polycrystalline samples of copper, silver and gold and of a single crystal of copper in the range 4.2 to 15°K. The results obtained for copper were in excellent agreement with the work of other researchers and the error estimates were sufficiently small to show that the theoretical calculations of Collins are not supported by measurements on a polycrystalline specimen of copper. Below 15°K the data points were well represented by the equation: 1010a=1.54+/-0.04 T+0.275+/-0.0027T 3 The results obtained for a single crystal of copper were significantly different from those obtained for a polycrystalline sample yet they are also in disagreement with the theoretical value. Below 15°K the data fitted the equation: 1010a=3.13+/-0.05 T+0.255+/-0.003T 3 Values of Yo (the low temperature limiting value of the Gruneisen parameter) for silver and gold were measured to be 2.04 +/- 0.06 and 2.91 +/- 0.02 respectively. The agreement with the theoretical values 2.22 and 2.92 is quite good. Below 6°K the thermal expansion of silver and gold was found to be anomalous as it was no longer proportional to the specific heat of these metals. In order to obtain high accuracy in the values of thermal expansion it was necessary to measure temperature to about 0.01°K. For this purpose a method was developed to obtain an interpolation of the resistance versus temperature function in the range 4.2 to 10°K. This capability permitted a theoretical study of the electrical resistivity of pure platinum which indicated that d-band electrons contribute significantly to the conductivity at low temperatures. In the hope of obtaining better measurements of temperature indium resistance thermometers were designed and constructed. Their reproducibilities were measured and were found to exceed previously reported values for indium resistance thermometers.
Cultural Renewal in Aboriginal Theatre Aesthetics
Creators: name: Lachance, Lindsay
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Aboriginal
Contemporary Canadian Theatre
Aboriginal Theatre Canada
Floyd Favel
Native Earth Performing Arts
Native Performance Culture
Storytelling

description: The goal of this research is to shed light on current developments in the field of Aboriginal Theatre Studies. This investigation encourages the reader to look again at the ways in which elements of Aboriginal culture are manifesting in contemporary theatre. Aboriginal theatre is increasingly visible in Canada and its cachet is growing with both artists and audiences. As a result, culturally specific worldviews and traditional practices are being introduced to mainstream Canadian theatre audiences. Through interviews with practicing Aboriginal artists like Floyd Favel, Yvette Nolan and Marie Clements and through an exploration of their individual theatrical processes, this research has attempted to identify how practicing Aboriginal artists consciously privilege Indigenous ways of knowing in their approaches to creating theatre for the contemporary stage.
…And All the World a Dream: Memory Outlining the Mysterious Temperature-Dependency of Crystallization of Water, a.k.a. the Mpemba Effect
Creators: name: Uskokovic, Vuk
name: Uskokovic, Evangelina
name: Uskokovic, Theo
name: Wu, Victoria
Publisher: name: Substantia
Year: 2020

description: Introduction Year 2019 marked the semi-centennial since the release of Cool?, a seminal paper by Mpemba and Osborne that demonstrated the counterintuitively faster crystallization of warm water than the cold one when they are both cooled under the same conditions. Objective This docufiction piece celebrates the “cool” of the story around the discovery of this effect by taking the form of a play during which a scientific study elucidating the mechanistic origins of this peculiar effect was performed and discussed. Methods This play celebrating scientific research as a literal play takes place over the period of 24 hours on an autumn day in 2019 and is divided to four acts: the noon (Act I), the afternoon (Act II), the night (Act III), and the sunrise (Act IV). It is interjected with diegetic musical lines that are sang by the muses in the alternate version and by the characters per se in this version, either acapella or to the tunes played by an onstage radio. The protagonists of the play are a husband (VU) and a wife (VW) scientists on exile from scientific institutions and their two children, a first-grader (TU) and a preschooler (EU), implying the study’s strong educational character, alongside the philosophical and moralistic. Results Through the simple kinetic analyses of the crystallization of water and the melting of ice, but also more complex light scattering, optical absorbance, infrared imaging and X-ray diffraction analyses, the study provides observations that support the hypothesis of structural memory in the liquid state as a key factor explaining the Mpemba effect. As per this explanatory model, the increased polydispersity and delayed relaxation of cluster symmetries forming in the preheated water allow it to crystallize faster than the initially cold water. This is made possible either by the direct semblance of an unrelaxed population of high-temperature clusters to the space group of ice Ih or by preserving the dynamic conditions for cluster reorganization that shorten the stochastic search for configurations that facilitate the transition to the solid state at or around the freezing point. Air cavities in the liquid phase, including micro- and nano-bubbles, are shown not to be responsible for the Mpemba effect. However, larger temperature gradients and densities of convection streams in the preheated water get partially preserved during cooling, rendering the occurrence of this anomalous phenomenon feasible. Parallels with hydroxyapatite, the most abundant inorganic material in our bodies after water, were made during the discussion. Conclusions It is concluded that structural memory allows water to exhibit the Mpemba effect and that science belongs to the province of children of all ages.
description: Substantia, Vol. 4 No. 2 (2020)
Optical sensing in a microfluidic device
Creators: name: Weber, Stephen Karl-Alan
Publisher: name: Swinburne
Year: 2024

description: Stephen's research focused on the development of a high resolution microfluidic based optical biosensor. With microfluidic systems, measurements or sample manipulation that would otherwise require human involvement and costly laboratory equipment can now be performed on portable, disposable devices. Microfluidic devices with integrated optical sensing are able to analyse samples, at the bed-side, in the nano-litre quantities and are destined to become an essential tool in biotechnology and biomedicine. Stephen successfully demonstrated a microfluidic device capable of manipulating and trapping micrometer-sized particles that can be used as localised optical sensors for biological research, including stem cells and drug discovery.
The Role of the Defective Nav1.4 Channels in the Mechanism of Hyperkalemic Periodic Paralysis
Creators: name: Lucas, Brooke
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Hyperkalemic periodic paralysis
Nav1.4 sodium channels

description: Hyperkalemic periodic paralysis (HyperKPP) is an autosomal dominant human skeletal muscle channelopathy that causes periods of myotonic discharge and periodic paralysis due to defective Nav1.4 sodium channels. Patients are asymptomatic at birth, attacks become short and frequent during childhood, and more severe during adolescence. Since the Nav1.4 content in the cell membrane is relatively constant during childhood, it was hypothesized that some symptoms start with the defective Nav1.4 channels, while other symptoms start after some changes occur in gene expression affecting other membrane channel content and/or activity. To test the hypothesis, the contractile characteristics of EDL and soleus muscles from HyperKPP mice from the age of 0.5 to 12 months were tested in vitro. For both EDL and soleus, contractile defects, including low force generation, instability and large unstimulated force were observed by two weeks of age. With aging, the defects did not worsen, but muscles actually showed some improvement. Considering that Nav1.4 protein content reaches maximum at three weeks of age, the data suggests that HyperKPP symptoms are solely due to the defective Nav1.4 channels.
Early Industrial Roots of Green Chemistry - II
Creators: name: Murphy, Mark A
Publisher: name: Substantia
Year: 2020

description: Many literature articles and/or conventional histories of “Green Chemistry” describe its start as being a result of actions at the US Environmental Protection Agency (“EPA”) and/or in Academia during the 1990’s. But many examples of environmentally friendly Real-World chemical processes were invented, developed and commercialized in the oil refining, commodity chemical, and consumer product industries starting about the time of World War II. Those efforts dramatically accelerated and evolved into explicitly environmentally oriented “Pollution Prevention” efforts during the 1970’s and 1980’s. A UN conference in November 1976 brought together over 150 attendees from industry, academia, and governmental and non-governmental organizations from 30 countries to address environmental issues related to preventing pollution caused by the chemically-related industries. Seventy-nine papers published in 1978 from the conference proceedings (titled “Non-Waste Technology and Production”) addressed a wide variety of technical, economic, environmental, and policy issues and approaches, and documented many examples of already commercialized environmentally friendly chemically based processes. On a parallel track, in 1975 the 3M Corporation initiated a major corporate-wide program called “Pollution Prevention Pays (“3P”) that commercialized thousands of environmentally oriented Real-World processes and/or inventions, in many countries, and simultaneously saved 3M large sums of money. Similar “Pollution Prevention” approaches were emulated and elaborated by many chemically based corporations in many countries during the 1980s. The “Green Chemistry” terminology adopted by the EPA and Academia in the 1990’s evolved from the “Pollution Prevention” approaches, programs, and commercialized inventions that had occurred long before the 1990s.
description: Substantia, Vol. 4 No. 2 (2020)
Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
Creators: name: Najem, Dema
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Alzheimer's disease
Insulin resistance
Cholesterol dysregulation
Neuroinflammation
Aβ

description: Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) and tau pathologies, insulin resistance, neuro-inflammation and dysregulation of cholesterol homeostasis, all of which play a role in neuro-degeneration. The main aim of this study was to determine possible relationships between insulin signaling, cholesterol biosynthesis and their effects on Aβ, and inflammatory response in vitro. Insulin treatment increased cholesterol synthesis in human Neuroblastoma SH-SY5Y (SHY) and mouse neuroblastoma 2a (N2a) and N2a transfected with human APP (N2a-APP) by up-regulating biosynthesis enzymes including 24-dehydrocholesterol reductase (DHCR24) and 3-hydroxy-3methyl-glutaryl-CoA reductase (HMGCR) through sterol regulatory element binding protein-2 (SREBP2) up-regulation. Aβ caused insulin resistance in N2a-APP cells by phosphorylating IRS-1 at Ser612, inhibiting signaling to downstream targets. Aβ1-42-treated SHY exhibited similar IRS-1 phosphorylation at Ser612 and inflammatory response of JNK activation. Aβ1-42 caused down-regulation of neuro-protective/anti-inflammatory DHCR24, and an increase in HMGCR levels indicating dysregulation of cholesterol homeostasis in SHY cells. Insulin resistance, Aβ toxicity, neuro-inflammation and dysregulation of cholesterol homeostasis appear to be intertwined processes in AD that should be studied simultaneously.
Eleanor DICKEY, Latein lernen wie in der Antike. Latein-Lehrbücher aus der Antike. Aus dem Englischen übersetzt von Marion SCHNEIDER
Creators: name: Frisch, Magnus
Publisher: name: Göttinger Forum für Altertumswissenschaft
Year: 2024

description: Rezension zu: Eleanor Dickey, Latein lernen wie in der Antike. Latein-Lehrbücher aus der Antike. Aus dem Englischen übersetzt von Marion Schneider. Basel/Berlin: Schwabe Verlag 2022, 217 S., 5 s/w-Abb., ISBN: 978-3-7965-4088-2
description: Göttinger Forum für Altertumswissenschaft, Bd. 27 Nr. 1 (2024): Göttinger Forum für Altertumswissenschaft
title: Investigating regional source and sink patterns of Alpine CO2 and CH4 concentrations based on a back-trajectory receptor model
title: Investigating regional source and sink patterns of Alpine CO2 and CH4 concentrations based on a back-trajectory receptor model
titleType: AlternativeTitle
Creators: name: Giemsa, Esther
name: Jacobeit, Jucundus
name: Ries, Ludwig
Publisher: name: My University
Year: 2019
Subjects: Kohlendioxidgehalt

description: The main purpose of this paper is to contribute to the improvement in the present knowledge concerning regional carbon dioxide (CO2) and methane (CH4) exchange as an essential step towards reducing the uncertainties along with bottom-up estimations of their global budget by identifying the characteristic spatial and temporal scales of the regional greenhouse gas fluxes. To this end, we propose a stepwise statistical top-down methodology for examining the relationship between synoptic-scale atmospheric transport patterns and mole fractions of the climate gases to finally receive a characterisation of the sampling sites with regard to the key processes driving the CO2 or CH4 concentration levels. Quelle: https://link.springer.com/
On Some Problems in Transcendental Number Theory and Diophantine Approximation
Creators: name: Nguyen, Ngoc Ai Van
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: uniform exponent of approximation
small value estimate
Diophantine approximation
Chow form
minimal points

description: In the first part of this thesis, we present the first non-trivial small value estimate that applies to an algebraic group of dimension 2 and which involves large sets of points. The algebraic group that we consider is the product ℂ× ℂ*, of the additive group ℂ by the multiplicative group ℂ*. Our main result assumes the existence of a sequence (PD)D ≥1 of non-zero polynomials in ℤ [X1, X2] taking small absolute values at many translates of a fixed point (ξ, η) in ℂ × ℂ* by consecutive multiples of a rational point (r, s) ∈ (ℚ*)2 with s = ±1. Under precise conditions on the size of the coefficients of the polynomials PD, the number of translates of (ξ, η) and the absolute values of the polynomials PD at these points, we conclude that both ξ and η are algebraic over ℚ. We also show that the conditions that we impose are close from being best possible upon comparing them with what can be achieved through an application of Dirichlet’s box principle. In the second part of the thesis, we consider points of the form θ = (1,θ1 , . . . ,θd-1 ,ξ) where {1,θ1 , . . . ,θd-1 } is a basis of a real number field K of degree d ≥ 2 over ℚ and where ξ is a real number not in K. Our main results provide sharp upper bounds for the uniform exponent of approximation to θ by rational points, denoted λ ̂(θ), and for its dual uniform exponent of approximation, denoted τ ̂(θ). For d = 2, these estimates are best possible thanks to recent work of Roy. We do not know if they are best possible for other values of d. However, in Chapter 2, we provide additional information about rational approximations to such a point θ assuming that its exponent λ ̂(θ) achieves our upper bound. In the course of the proofs, we introduce new constructions which are interesting by themselves and should be useful for future research.
Lignin to Materials : A Focused Review on Recent Novel Lignin Applications
Creators: name: Yu, Osbert
name: Kim, Kwang Ho
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: In recent decades, advancements in lignin application include the synthesis of polymers, dyes, adhesives and fertilizers. There has recently been a shift from perceiving lignin as a waste product to viewing lignin as a potential raw material for valuable products. More recently, considerable attention has been placed in sectors, like the medical, electrochemical, and polymer sectors, where lignin can be significantly valorized. Despite some technical challenges in lignin recovery and depolymerization, lignin is viewed as a promising material due to it being biocompatible, cheap, and abundant in nature. In the medical sector, lignins can be used as wound dressings, pharmaceuticals, and drug delivery materials. They can also be used for electrochemical energy materials and 3D printing lignin–plastic composite materials. This review covers the recent research progress in lignin valorization, specifically focusing on medical, electrochemical, and 3D printing applications. The technoeconomic assessment of lignin application is also discussed.
Cdk1-Dependent Phosphorylation of the APC-Cdc20 Regulates its Activation at Anaphase Onset in S. cerevisiae
Creators: name: Williams, Elizabeth C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: The metaphase to anaphase transition of the cell cycle is triggered by activation of the anaphase promoting complex (APC) bound to its mitotic activator, Cdc20. The APC is a multisubunit E3 ubiquitin ligase that targets mitotic substrates for proteasomal degradation, including securin (Pds1 in S. cerevisiae), which allows for the separation of sister chromatids at anaphase onset. Activation of the APC is thought to be regulated by both Cdk1-dependent phosphorylation and the binding of Cdc20. We show that inhibition of Cdk1-dependent phosphorylation of the APC, by overexpression of the tyrosine kinase Wee1 (Swe1 in S. cerevisiae), stabilizes mitotic substrates, impairs sister chromatid separation and arrests cells in metaphase. Inhibition of Cdk1-dependent phosphorylation of the APC also inhibits ubiquitination activity in vitro. We further show that although Cdk1 phosphorylation of the subunits Cdc16, Cdc23 and Cdc27 is important for ubiquitination activity, Cdk1 likely phosphorylates additional subunits of the APC that contribute to maximal activity at the metaphase-anaphase transition. In contrast to previous reports, however, we find that this phosphorylation does not influence binding of the mitotic activator, Cdc20. Mitotic APC activity is also regulated by the spindle assembly checkpoint (SAC), which inhibits Cdc20-dependent activity in response to spindle damage or unattached kinetochores. We find that preventing Cdk1-dependent phosphorylation of the TPR subunits delays recovery from activation of the SAC. We also show that preventing this phosphorylation in combination with loss of the APC subunits Cdc26 and Mnd2 causes sensitivity to activation of the spindle assembly checkpoint. Overall, we argue that Cdk1-dependent phosphorylation is important for APCCdc20 activity at the metaphase-anaphase transition. In addition, our data suggests that this phosphorylation may also be important for normal SAC function, defining a novel function for Cdk1 phosphorylation of the APC.
Entropy as the Driving Force of Pathogenesis: an Attempt of Diseases Classification Based on the Laws of Physics
Creators: name: Schwartz, Laurent
name: Devin, Anne
name: Bouillaud, Frédéric
name: Henry, Marc
Publisher: name: Substantia
Year: 2020

description: In nature, every physical process involving matter is ruled by the second law of thermodynamics (the total entropy of an isolated system can never decrease over time, and is constant if and only if all processes are reversible). The living cell being a material system should comply by releasing entropy either into the body or into the outside environment. In case of pathologies, entropy cannot be fully exported outside the body and stays inside the body either in the form of biomass, of extracellular waste products. We propose hereafter, a new way of classifying diseases by looking at the kind of entropy which cannot be easily excreted. In such a classification, inflammatory diseases play with entropy through increased heat, biomass synthesis (proliferation of lymphocytes and neutrophils) and secretion of pro-inflammatory proteins (waste products from the cell’s point of view). In the case of chronic inflammation, it induces mitochondrial impairment, owing to the increased oncotic pressure associated to hyper-osmolarity leading to cancer and degenerative diseases (DDs). In the special case of degenerative diseases, cellular entropy is mostly released in the form of wastes, such as amyloid plaques or Lewy’s bodies, and not as proliferating cells as in cancer. Consequently, despite quite different symptoms, these two diseases are proposed to be Janus-like twins, meaning that a remedy active against cancer, should also be active against various forms of DDs.
description: Substantia, Vol. 4 No. 2 (2020)
Survey
Creators: name: Pirog, Stephen
name: Rosenberg, Eric
name: Surface, Debra lee
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 350607
subject: Marketing technology
classificationCode: 350606
subject: Marketing research methodology
classificationCode: 350605
subject: Marketing management (incl. strategy and customer relations)

description: Companion file to "Solver." In-class MDS assignment for making perceptual maps, discussed in an article under review
An empirical investigation of embodiment in the 'Heal' concept
Creators: name: Leitan, Nuwan
Publisher: name: Swinburne
Year: 2024

description: Cognition may not be restricted to the mind. Embodied cognition approaches argue that the body is intertwined in conceptual knowledge. This project aimed to investigate the concept heal from an embodied cognition perspective - in particular its relationship with the bodily experience of looking upwards (i.e., the 'up bodily state'). The project consisted of three studies which found that; 1) linguistically, abstract concepts evoke emotional responses, and 2) that the 'up bodily state' partially facilitates the perception of healing, and decision making about the heal concept. These findings encourage experience-based teaching techniques for abstract concepts and the use of posture to enhance physical and psychological healing.
Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance
Creators: name: Drayton, Matthew
name: Kizhakkedathu, Jayachandran N.
name: Straus, Suzana
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Antimicrobial peptides (AMPs), otherwise known as host defence peptides (HDPs), are naturally occurring biomolecules expressed by a large array of species across the phylogenetic kingdoms. They have great potential to combat microbial infections by directly killing or inhibiting bacterial activity and/or by modulating the immune response of the host. Due to their multimodal properties, broad spectrum activity, and minimal resistance generation, these peptides have emerged as a promising response to the rapidly concerning problem of multidrug resistance (MDR). However, their therapeutic efficacy is limited by a number of factors, including rapid degradation, systemic toxicity, and low bioavailability. As such, many strategies have been developed to mitigate these limitations, such as peptide modification and delivery vehicle conjugation/encapsulation. Oftentimes, however, particularly in the case of the latter, this can hinder the activity of the parent AMP. Here, we review current delivery strategies used for AMP formulation, focusing on methodologies utilized for targeted infection site release of AMPs. This specificity unites the improved biocompatibility of the delivery vehicle with the unhindered activity of the free AMP, providing a promising means to effectively translate AMP therapy into clinical practice.
Towards Development of Ontology-Based Context-aware Persuasive Applications Promoting Physical Activity
Creators: name: Montaghami, Valeh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: Modern lifestyle is becoming more sedentary. As a consequence, many ubiquitous computing and mobile technologies have been designed to motivate people towards more active lifestyles. The concept of context-awareness is one important aspect of ubiquitous computing technologies. Context-aware applications and devices can deliver relevantly specific information and services with respect to users' needs and well adapt to their constantly changing environment. Therefore, context-awareness is now becoming critical in the development of ubiquitous and mobile technologies encouraging physical fitness. However, appropriately exploiting, representing and managing contextual information poses a serious challenge. There is a need for a formal context model facilitating context sharing, knowledge reasoning, and interoperability among diverse systems. Ontology-based context modeling can address these issues. Therefore, the present thesis proposes as a solution, the concept of context ontology, called Extensible Context Ontology for Physical Activity (ECOPA), and the architecture, abbreviated as CAPPA, to facilitate the development of Context-Aware Persuasive applications promoting Physical Activity. Furthermore, an application prototype called ExePeEnhancer, has been built and verified through experimentations to demonstrate the effectiveness of development of applications based on the proposed architecture and ontology. The evaluation results have shown that ExePeEnhancer as a persuasive application that accounts for different contexts, exhibits more effectiveness than a persuasive application that does not take those contextual information into consideration.
Some Thoughts Written on ‘Juneteenth’ of 2020, the Day Commemorating the End of Slavery in the United States, June 19, 1865, at the End of our Civil War
Creators: name: Weiss, Richard G.
Publisher: name: Substantia
Year: 2020

description: We are human beings, imbued with the ability to make decisions and think deductively and inductively. However, our ability to do so is related asymmetrically to external factors such as wealth and physical strength; some are imbued with more power than others and use that extra power as a tool to influence how fair and equitable are defined or, in extreme cases, to oppress the weaker. As a consequence, individuals and groups sometimes behave in ways that are destructive both physically and emotionally to others. Thus, it is not surprising that throughout our recorded history there have been actions affecting masses of people that we consider (at least in retrospect) to be based on illogical and uncivilized criteria. After all, we are human beings.
description: Substantia, Vol. 4 No. 2 (2020)
Maple Sugar Bush Management and Biodiversity Conservation in Eastern Ontario, Canada
Creators: name: Clark, Kristin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: sugar bush
maple syrup
biodiversity conservation
woodlot management
Eastern Ontario

description: This thesis examines the extent to which sugar bush management in Eastern Ontario might contribute to biodiversity maintenance and conservation and therefore be promoted as a form of rural sustainable development. Ontario government policy seeks to actively promote actions that strengthen the province’s rural communities and protect biodiversity. Therefore sustainable development is an important concept to encourage in rural areas. The production of maple syrup on sugar bushes has already been demonstrated to be economically, socially, and in some aspects ecologically sustainable. This study seeks to determine how the operation of sugar bushes might also contribute to ecological sustainability through the maintenance and conservation of forest biodiversity. I identified three documents published by the Eastern Ontario Model Forest (EOMF): a set of management principles for conserving biodiversity on private woodlots, a list of biodiversity indicators, and a manual for monitoring them. I monitored three of the biodiversity indicators (spring ephemerals, birds, and frogs) on three of the larger sugar bushes in the Eastern Ontario and established that the EOMF biodiversity monitoring practices and guidelines were suitable for working sugar bushes. Using the management principles for biodiversity conservation developed by the EOMF, I interviewed 22 sugar bush operators in Eastern Ontario. With these interviews I addressed two objectives: 1. To generate empirical information regarding the management practices of maple sugar bush operators in Eastern Ontario and to compare these with established management principles for forest biodiversity conservation in the region 2. To generate suggestions for woodlot operators and government policymakers alike about future opportunities for research and management decision-making. The results of the study show that although most operators do not have a formal management plan for their sugar bush, many of their management practices are consistent with prescribed biodiversity conservation principles. Sugar bush operators are receptive to conserving biodiversity on their properties. The findings suggest that through sound management and planning, small-scale commercial sugar bush operations generally can be made environmentally sustainable, and become important components in broader rural development strategies. This study provides new insights into how small-scale sugar bush management, when practiced well, is consistent with conservation principles and with sustainable development principles more generally. It shows how sugar bush operators in Eastern Ontario can help the province reach its goals of biodiversity conservation and rural development set out in Ontario’s Biodiversity Strategy (2005) and Ontario’s Rural Plan (2004).
title: National implementation plan of the Federal Republic of Germany to the Stockholm Convention
title: National implementation plan of the Federal Republic of Germany to the Stockholm Convention
titleType: AlternativeTitle
Creators: name: Rauert, Caren
Publisher: name: Umweltbundesamt
Year: 2017
Subjects: subject: Umweltbundesamt
subject: Chemikalien

description: In the National Implementation Plan, Germany describes the measures taken to implement the obligations under the Stockholm Convention. These include both the legal measures implementing these obligations into national and European law and measures to reduce or eliminate releases of persistent organic pollutants (POPs) from intentional and unintentional production and use as well as from stockpiles and wastes. Also, measures for public information, awareness developing and education as well as research, development and monitoring are included. The National Implementation Plan is reviewed periodically. Quelle: https://www.umweltbundesamt.de
description: In the National Implementation Plan, Germany describes the measures taken to implement the obligations under the Stockholm Convention. These include both the legal measures implementing these obligations into national and European law and measures to reduce or eliminate releases of persistent organic pollutants (POPs) from intentional and unintentional production and use as well as from stockpiles and wastes. Also, measures for public information, awareness developing and education as well as research, development and monitoring are included. The National Implementation Plan is reviewed periodically.
title: Реконструктивно-пластические операции при раннем раке молочной железы
Creators: name: Николаева, Т. И.
name: Жарникова, Т. Н.
name: Иванов, П. М.
Publisher: name: Реноме
Year: 2018

description: Существующие в мировой практике тенденции в хирургии при раке молочной железы направлены на более консервативный подход к объему хирургического вмешательства. Однако возможность проведения органосохраняющих реконструктивно-пластических операций напрямую зависит от стадии заболевания и должно выполняться по строгим показаниям.
Banning Bottled Water in Concord, MA: How an Apolitical Commodity Became Political
Creators: name: Begg, Rachel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: water
bottled water
commodity
Concord
local activism
ban
environmental activism
activism
environmental politics
tap water
fountains

description: This thesis paper explores how various actors gathered around bottled water when a ban was put into place in Concord, Massachusetts. The objective has been to answer the following questions: How does an apolitical commodity become a political one? Specifically, how does bottled water move from being an apolitical commodity to become a highly political one? What does this mean for environmental politics? I situate my theoretical approach within Martha Kaplan’s research with fountains and coolers. I use Bruno Latour to show in which ways this ban became a matter of concern, as well as how the ban and the plastic bottle are actors. I conducted fieldwork in Concord and I interviewed participants. My findings reveal that the ban brought meanings to the surface and challenged them or supported them in various ways. The discussions turned from the impact of bottled water on our environment to the political impact of bottled water companies and large corporations on local Concord issues.
The Multimodal Interaction through the Design of Data Glove
Creators: name: Han, Bote
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Data glove
Gesture Recognition

description: In this thesis, we propose and present a multimodal interaction system that can provide a natural way for human-computer interaction. The core idea of this system is to help users to interact with the machine naturally by recognizing various gestures from the user from a wearable device. To achieve this goal, we have implemented a system including both hardware solution and gesture recognizing approaches. For the hardware solution, we designed and implemented a data glove based interaction device with multiple kinds of sensors to detect finger formations, touch commands and hand postures. We also modified and implemented two gesture recognizing approach based on support vector machine (SVM) as well as the lookup table. The detailed design and information is presented in this thesis. In the end, the system achieves supporting over 30 kinds of touch commands, 18 kinds of finger formation, and 10 kinds of hand postures as well as the combination of finger formation and hand posture with the recognition rate of 86.67% as well as the accurate touch command detection. We also evaluated the system from the subjective user experience.