cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of CD36-Induced Anti-Angiogenic Signalling Platform via Proximity Biotinylation
Creators: Saini, Arashdeep S
Publisher: name: University of Alberta Library
Year: 2024

In response to hypoxic conditions, tumours secrete pro-angiogenic factors that stimulate the development of new blood vessels. Given the critical role of angiogenesis in tumour progression, therapies counteracting cancer neovascularization have been developed. However, clinical studies have shown these therapies to be only temporarily effective; thus, further research is needed to enhance our understanding of anti-angiogenic signalling. Our research has focused on elucidating the anti-angiogenic response stimulated by thrombospondin-1 (TSP-1) binding to cell surface receptor CD36. While F-actin, Fyn (an Src-family kinase), and CD36 nanoclusters are essential components of TSP1-induced anti-angiogenic response, the interactions between these molecules have yet to be discovered. Given the small size of CD36 cytosolic domains, we hypothesize that additional proteins within CD36 nanoclusters are crucial for its function. By identifying and investigating the role of these proteins, we seek to decipher the set of interactions necessary for CD36 anti-angiogenic signalling and organization. Here we developed a proximity biotinylation technique to identify proteins in the vicinity of CD36 via mass spectrometry. Proximity biotinylation has revealed a list of candidate proteins potentially important in CD36 signalling and organization. shRNA knockdown of candidate proteins revealed integrin beta-1 (ITGB1) to be essential for CD36-Fyn signalling. Furthermore, proximity ligation assay and conditional colocalization analysis provide support for a CD36, ITGB1, and CD9 molecular complex, implicated in anti-angiogenic signalling. Our approach to investigating CD36 nanodomains has not only revealed potential targets to reduce tumour angiogenesis it has also provided a roadmap to investigate the organization of other membrane proteins within their native states.
Additional file 1 of Differential vulnerability of the dentate gyrus to tauopathies in dementias
Creators: name: Kawles, Allegra
name: Minogue, Grace
name: Zouridakis, Antonia
name: Keszycki, Rachel
name: Gill, Nathan
name: Nassif, Caren
name: Coventry, Christina
name: Zhang, Hui
name: Rogalski, Emily
name: Flanagan, Margaret E.
name: Castellani, Rudolph
name: Bigio, Eileen H.
name: Mesulam, M. Marsel
name: Geula, Changiz
name: Gefen, Tamar
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy

description: Additional file 1. Individual characteristics of all cases.
Additional file 1 of A balance focused biometric does not predict rehabilitation needs and outcomes following total knee arthroplasty
Creators: name: Lee, Jonathan J.
name: Arora, Prerna
name: Finlay, Andrea K.
name: Amanatullah, Derek F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1
Appendix_A_Diverse_Effects_of_CEIPV – Supplemental material for Diverse Long-Term Effects of Childhood Exposure to Intimate Partner Violence: Development of Externalizing Behaviors in Males and Females
Creators: name: Weir, Henriikka
name: Kaukinen, Catherine
name: Cameron, Alesha
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, Appendix_A_Diverse_Effects_of_CEIPV for Diverse Long-Term Effects of Childhood Exposure to Intimate Partner Violence: Development of Externalizing Behaviors in Males and Females by Henriikka Weir, Catherine Kaukinen and Alesha Cameron in Journal of Interpersonal Violence
Additional file 1 of Influence of elastomeric and steel ligatures on periodontal health during fixed appliance orthodontic treatment: a systematic review and meta-analysis
Creators: name: Hussain, Umar
name: Campobasso, Alessandra
name: Noman, Muhammad
name: Alam, Shamsul
name: Mujeeb, Rida
name: Shehzad, Sofia
name: Papageorgiou, Spyridon N.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Deep Learning-based Segmentation for Complex Scene Understanding
Creators: Ji, Wei
Publisher: name: University of Alberta Library
Year: 2024

Deep learning-based segmentation plays a crucial role in computer and robot vision. Traditional approaches have predominantly relied on RGB (i.e., color) imagery, given its widespread availability and usage. However, the innate issues with color imagery, such as cluttered backgrounds and poor lighting, have significantly influenced the performance of existing segmentation methods under complex visual scenes. This thesis is an attempt seeking to advance the capabilities of deep learning-based segmentation for complex scene understanding by investigating additional imaging modalities.

This thesis navigates two innovative avenues: 1) incorporating depth data to comprehensively understand the 3D spatial layout of scenes, and 2) using thermal infrared imagery to enhance vision under adverse lighting conditions. In the first avenue, we concentrate on RGB-depth segmentation and propose three novel strategies to improve segmentation efficacy by optimizing three key aspects of deep learning models, namely, network input, network architecture, and network supervision. These strategies involve calibrating the inherent bias in depth inputs for better scene layout depiction, developing advanced network architectures for improved multimodal information fusion and contextual comprehension, and harnessing depth map geometry for facilitating unsupervised RGB-D segmentation, thus reducing reliance on extensive human annotations. In the second avenue, we delve into RGB-Thermal (multispectral) segmentation, which is a relatively less-explored territory. We introduce the SemanticRT dataset, an extensive and large-scale resource for segmenting images under varied illumination conditions, and an innovative explicit complement modeling (ECM) framework to enhance modality-specific cue utilization and cross-modal feature fusion. Additionally, we pioneer the RGB-Thermal segmentation in the video domain, by presenting the first multispectral video semantic segmentation benchmark dataset - MVSeg, and developing an efficient MVNet baseline framework to jointly learn semantic representations from multispectral and temporal contexts.

Extensive evaluations across ten segmentation datasets demonstrate that our proposed methodologies significantly outperform existing state-of-the-art solutions in handling challenging scenarios, heralding advancements in deep learning-based segmentation. This thesis also discusses the benefits and limitations of a recent foundational model - Segment Anything Model, and outlines some compelling issues and future research avenues within the field. Importantly, we advocate for open access, making our source codes, models and datasets publicly available to foster reproducibility and encourage collaborative research efforts.
VanDerVeldenRevised_Supplemental_Table_S1_en_s2 – Supplemental material for Do Measures of Posttrauma Factors Better Explain PTSD Severity Than Pretrauma Factors? An Empirical Reply to Ogle et al. (2016)
Creators: name: Velden, Peter G. Van Der
name: Knaap, Leontien M. Van Der
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, VanDerVeldenRevised_Supplemental_Table_S1_en_s2 for Do Measures of Posttrauma Factors Better Explain PTSD Severity Than Pretrauma Factors? An Empirical Reply to Ogle et al. (2016) by Peter G. van der Velden and Leontien M. van der Knaap in Clinical Psychological Science
Study of the C genome QTL affecting flowering time in spring oilseed Brassica napus  under a short-day condition
Creators: Nupur, Juthy Abedin
Publisher: name: University of Alberta Library
Year: 2024

Brassica napus, mostly known as canola, is an important oilseed crop in Canada. Earliness

of flowering and maturity are one of the important traits for growing spring canola in North

America. These traits can be improved through identification of the genes and alleles affecting

flowering time and understanding their effect on other traits. In this study, near-isogenic lines

(NILs) carrying flowering time QTL alleles of Brassica oleracea or B. napus which located on C1

or C9 chromosome were evaluated under 10 hr photoperiod condition for morphological and root

and shoot biomass traits to understand the effect of these QTL alleles on the other traits. The NILs

carrying C1 or C9 allele of B. oleracea flowered earlier, as expected, and no visible difference was

observed between the NILs and the recurrent parent for leaf characteristics. However, the NILs

showed significant difference for plant height, shoot and root biomass indicating that the flowering

time QTL alleles may exert pleiotropic effect on these traits or QTL affecting these traits are

located in the same genomic region. This thesis research also included expression analysis of

putative flowering time genes from C5 and C9 flowering time QTL. For this, a set of early- and

late-flowering B. napus lines developed from a B. napus × B. oleracea interspecific cross were

used, and expression analysis of 30 flowering genes from C5 (15) and C9 (15) QTL was carried

out on leaf and shoot apex tissue collected from the plants grown under 10 hr photoperiod

condition. A majority of the genes showed a greater expression at night than in morning, and

significant differential expression was observed for CO, PHYA, FT, AP2, SOC1 and TEM1; this

suggests that these genes might be involved in flowering time variation between the early and late

flowering lines. The leaf materials of the above-mentioned early- and late-flowering plants were

also used in a proteomic study to identify the proteins involved in flowering time variation. This

study identified the proteins involved in photosynthesis, pigmentation, phytohormone signaling,

stress response, ROS, ion binding, mRNA binding, protein binding and many others. Thus, this

thesis research showed that the flowering time alleles can exert effect on other morphological and

physiological traits, and the research also identified the genes and proteins potentially involved in

the regulation of flowering time in canola under short-day photoperiod conditions.
Supplemental Material, Appendix_1_How_To_Engage_Citizens_Questionnaire - Characterizing Citizens’ Preferences for Engagement in Patient Care and Research in Adult and Pediatric Intensive Care Units
Creators: name: Burns, Karen E. A.
name: Rizvi, Leena
name: Charteris, Anna
name: Laskey, Samuel
name: Bhatti, Saima B.
name: Kamalprit Chokar
name: Choong, Karen L. M.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, Appendix_1_How_To_Engage_Citizens_Questionnaire for Characterizing Citizens’ Preferences for Engagement in Patient Care and Research in Adult and Pediatric Intensive Care Units by Karen E. A. Burns, Leena Rizvi, Anna Charteris, Samuel Laskey, Saima B. Bhatti, Kamalprit Chokar and Karen L. M. Choong in Journal of Intensive Care Medicine
Additional file 1 of Family wellbeing in general practice: a study protocol for a cluster-randomised trial of the web-based resilience programme on early child development
Creators: name: Overbeck, Gritt
name: Kragstrup, Jakob
name: Gørtz, Mette
name: Rasmussen, Ida Scheel
name: Graungaard, Anette Hauskov
name: Siersma, Volkert
name: de Voss, Sarah
name: Ertmann, Ruth Kirk
name: Shahrzad, Sinead
name: Appel, Clara Lundmark
name: Wilson, Philip
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Developmental Biology
Science Policy
Mental Health

description: Additional file 1. Web content description.
Perceptually Motivated Algorithms for Multimedia
Creators: Zhang, Shupei
Publisher: name: University of Alberta Library
Year: 2024

Perceptual factors in vision can facilitate the development of more effective multimedia algorithms. In particular, the wide dynamic range of the human vision system is a motivation for developing image lighting enhancement algorithms. Image lighting enhancement can be achieved by capturing multiple images with different exposure settings and then reconstructing a final image.  However, this approach cannot solve the problem of revealing or predicting details in already-captured images. Single-image lighting enhancement is desirable for this scenario, but many challenges remain to be addressed including over-enhancement, noise, and color artifacts due to a lack of understanding of the image content. Another aspect of multimedia algorithms that can benefit from perceptual factors, like the foveation mechanism and perceptual quality, is image and video compression. As the resolution and image quality of modern cameras have increased, the amount of data produced by computational photography has also surged dramatically. This has created a demand for better image/video compression methods that can reduce the data size without compromising the image quality.

In this thesis, four perceptually motivated methods are proposed to address the challenges in single-image lighting enhancement and image/video compression. First, we propose an image lighting enhancement method based on a fusion pyramid, which is a traditional contrast-based fusion approach. Second, we propose a self-attention-based learning strategy to reconstruct a properly exposed image from a single input image. We leverage the self-attention mechanism to model the interdependencies between different locations, and design a generative adversarial network (GAN) with a custom HDR loss function to improve the image quality. Third, we propose a novel video compression method that integrates visual saliency information with foveation to reduce perceptual redundancy.  This is an innovative approach to subsample and restore the input image using saliency data, which allocates more space for salient regions and less for non-salient ones. Finally, based on the assumption that a group of images can be decomposed into several shared feature matrices,  we propose a novel principal component approximation network (PCANet) for image compression. This is the first learning-based method that achieves promising performance while including the size of the network in the bitrate calculation.
Mineral Carbonation Potential and Transition Metal Migration in Kimberlite and Ultramafic Rocks: An Integrated Study of Acid Leaching, Enhanced Rock Weathering, and Microbial CO2 Sequestration
Creators: Wang, Baolin
Publisher: name: University of Alberta Library
Year: 2024

Carbonation of mafic and ultramafic rocks and mineral wastes provides a permanent way to sequester excess atmospheric CO2. Recent research has shown that this method also offers the potential for enhanced recovery of critical metals from mine tailings. This thesis presents a comprehensive study on the potential for CO2 sequestration through the carbonation of ultramafic rocks and mineral wastes from diamond mines. Utilizing a variety of analytical and experimental methods, this research aims to enhance our understanding of mineral carbonation processes and their application in offsetting CO2 emissions, while also exploring the recovery of critical metals from mine tailings.

The first part of the thesis introduces an innovative application of the Partial Or No Known Crystal Structure (PONKCS) method combined with the Rietveld method and X-ray diffraction (XRD) to perform Quantitative Phase Analysis (QPA). This approach overcomes the limitations of standard methods in quantifying structurally disordered minerals like lizardite and smectites in kimberlite, which are reactive to CO2. The study highlights the importance of instrument-specific calibration for accurate QPA and CO2 mineralization quantification in clay-rich rocks.

The second part of the thesis evaluates the carbonation potential of processed kimberlite from the Venetia diamond mine through column acid leaching experiments. The study demonstrates the feasibility of CO2 offset and critical metal recovery during mineral carbonation, with acid concentration significantly influencing the extraction of Mg and Ca, essential for carbon sequestration.

The third part of the thesis expands on the theme of accelerated carbon mineralization, investigating the influence of mineralogy on the weathering and carbonation potential of various ultramafic rocks and processed kimberlite. Through acid leaching experiments, the research underlines the crucial role of specific mineral compositions in determining the efficiency of CO2 sequestration and suggests a significant potential for offsetting greenhouse gas emissions from mining operations.

Finally, a field trial conducted over a year examines the effectiveness of pH-swing and cation exchange methods combining with microbially-mediated method for carbonating serpentine-, smectite- and calcite-rich processed kimberlite. The results indicate promising strategies for enhancing weathering and carbonation, tailored to the unique mineralogy of each rock type. The study advocates for the integration of acid leaching and microbially-mediated carbonation for calcite-poor residues, and a novel cation exchange approach for calcite-rich tailings, to maximize CO2 sequestration.
Supplementary_File_1 – Supplemental material for Overcoming Barriers: Individual Experiences Obtaining Medication-Assisted Treatment for Opioid Use Disorder
Creators: name: Scorsone, Krista L.
name: Haozous, Emily A.
name: Hayes, Leslie
name: Cox, Kim J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Supplementary_File_1 for Overcoming Barriers: Individual Experiences Obtaining Medication-Assisted Treatment for Opioid Use Disorder by Krista L. Scorsone, Emily A. Haozous, Leslie Hayes and Kim J. Cox in Qualitative Health Research
Gendered Experiences in the Wild: An Investigation of Constraints to Women’s Progression in Outdoor Recreation
Creators: Goodine, Janelle
Publisher: name: University of Alberta Library
Year: 2024

Traditional masculine narratives of outdoor recreation participation encourage domination of the natural world, and have supported narrow conceptualizations of outdoor recreationists. This legacy encourages competitive and exclusionary environments that are difficult to navigate, and disproportionately affects individuals with certain socio-demographic characteristics. The benefits derived from these activities are well-documented but continue to remain inaccessible for some people. The social construct of gender plays a particularly important role in the formation of outdoor recreation experiences yet, few qualitative studies have investigated women’s progression within outdoor recreation activities. Women are uniquely positioned to encounter, perceive, and negotiate leisure constraints, which alters their potential to engage in outdoor recreation activities. In adopting an interpretivist paradigm, the purpose of this research was to explore women’s experiences in outdoor recreation activities, and to understand the constraints that influence women’s developmental processes in activity engagement through the recreation specialization framework. Six women from different women’s only outdoor recreation groups in Alberta, Canada participated in the study through two focus groups and three semi-structured interviews. Reflexive thematic analysis was employed to develop five themes: (a) searching for journey, (b) pivotal moments in one’s journey, (c) deterring and defeating spaces (d) internal influences, and (e) community crafting. Results from this study offer insight about the potential gaps within the recreation specialization framework. This research contributes to the existing body of literature in leisure and recreation that warrants more critical examinations of the role of community to support women’s outdoor recreation journeys.
LINT: Assessing the Interpretability of Programmatic Policies
Creators: Bashir, Zahra
Publisher: name: University of Alberta Library
Year: 2024

Although the synthesis of programs encoding policies often carries the promise of interpretability, systematic evaluations were never performed to assess the interpretability of these policies, likely because of the complexity of such an evaluation. In this dissertation, we introduce a novel metric that uses large-language models (LLM) to assess the interpretability of programmatic policies. For our metric, an LLM is given both a program and a description of its associated programming language. The LLM then formulates a natural language explanation of the program. This explanation is subsequently fed into a second LLM, which tries to reconstruct the program from the natural-language explanation. Our metric then measures the behavioral similarity between the reconstructed program and the original. Our evaluation is based on the literature on program obfuscation, using it as a proxy for interpretability. We validate our approach with synthesized and human-crafted programmatic policies for playing a real-time strategy game, comparing the interpretability scores of these programmatic policies to obfuscated versions of the same programs. Our LLM-based interpretability score consistently ranks less interpretable programs lower and more interpretable ones higher. These findings suggest that our metric could serve as a reliable and inexpensive tool for evaluating the interpretability of programmatic policies.
Additional file 3 of Genome-wide landscape of RNA-binding protein (RBP) networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis
Creators: name: Nishanth, M. J.
name: Jha, Shanker
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3. RBPs and psychiatric disorders disorders.
Additional file 2 of Family wellbeing in general practice: a study protocol for a cluster-randomised trial of the web-based resilience programme on early child development
Creators: name: Overbeck, Gritt
name: Kragstrup, Jakob
name: Gørtz, Mette
name: Rasmussen, Ida Scheel
name: Graungaard, Anette Hauskov
name: Siersma, Volkert
name: de Voss, Sarah
name: Ertmann, Ruth Kirk
name: Shahrzad, Sinead
name: Appel, Clara Lundmark
name: Wilson, Philip
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Developmental Biology
Science Policy
Mental Health

description: Additional file 2. Trial set data registration.
Supplementary document for Polarization states and far-field optical properties in dielectric photonic crystal slabs - 6593738.pdf
Creators: name: Zagaglia, Luca
name: Zanotti, Simone
name: Minkov, Momchil
name: Liscidini, Marco
name: Gerace, Dario
name: Andreani, Lucio
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
Statistical Learning and Inference For Functional Predictor Models via Reproducing Kernel Hilbert Space
Creators: Liu, Meichen
Publisher: name: University of Alberta Library
Year: 2024

Functional regression is a cornerstone for understanding complex relationships where predictors or responses (or both) are functions. A particularly powerful framework within this domain is the Reproducing Kernel Hilbert Space (RKHS), which facilitates the handling of infinite-dimensional data through a finite set of parameters.

This thesis delves into three specific topics within functional regression using RKHS, showcasing innovative methodologies and their applications to real-world data. The first topic explores functional linear expectile regression, a method that offers a nuanced view of conditional response distributions, particularly beneficial for asymmetric distributions or when tail behaviour is of interest. The second topic ventures into functional smoothed score (SS) classification. The study investigates the functional classifier’s generalization ability and convergence property. The last chapter addresses the challenge of estimation and inference for the slope function in logistic regression under case-control designs, which exert influence over rare disease research.

The three topics contribute to functional regression, offering robust and theoretically sound methodologies for analyzing complex data structures. Through the representation theorem of RKHS, this thesis advances statistical modeling techniques and provides practical tools for tackling real-world problems in diverse scientific domains.
Additional file 1 of Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens
Creators: name: Wu, Tingyi
name: Wang, Yuexin
name: Yu, Jiazhi
name: Ren, Xiaotong
name: Li, Yuanting
name: Qiu, Weiqiang
name: Li, Xuemin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Stepwise multiple linear regression analysis for AUCdynamic and dynamic visual acuity in all defocus statuses.
Magnetotransport and thermoelectric studies of antiperovskite semimetal: Mn3SnC
Creators: name: Gangwar, Sunil
name: Sonika
name: Yadav, C. S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We explore the magnetotransport and thermoelectric (Seebeck and Nernst coefficients) properties of Mn3SnC an antiperovskite magnetic Nodal line semimetal. Mn3SnC shows paramagnetic (PM) to concurrent antiferromagnetic (AFM)/ferromagnetic (FM) transition at 286 K. The electrical resistivity and Seebeck coefficient indicate the importance of electron magnon scattering in the concurrent AFM/FM regime. We observed a large positive magnetoresistance (MR) of 8.2 at 8 T field near magnetic transition, in the otherwise negative MR behaviour for low temperatures. The electrical resistivity and MR show a weak thermal hysteresis around the boundary of transition temperature and the width of hysteresis decreases as magnetic field increases. Interestingly the Hall and Seebeck coefficients change sign from positive to negative below the transition temperature, highlighting the different scattering for holes and electrons in this multi-band system. The Seebeck and Nernst signal exhibit two sharp anomalies; one at the transition temperature and another at 50 K. The anomaly at magnetic transition in the Nernst signal disappear at 8 T magnetic field, owing to the reduction of magnetic fluctuation. A pseudo-gap near the Fermi level produces an upturn with a broad minimum in the Seebeck signal.
description: 8 Pages, 5 figures
Analyzing KataGo: A Comparative Evaluation Against Perfect Play in the Game of Go
Creators: Husna, Asmaul
Publisher: name: University of Alberta Library
Year: 2024

Research on board games focuses on playing at a superhuman level or finding

exact solutions. Recently, Artificial Intelligence (AI) has become really good

at playing complex games such as Go. Comparing AI systems to perfect play

helps us understand how advanced AI has become. This research explores the

performance of KataGo, an AlphaZero-like program, in the game of Go. Our

study investigates how different neural networks and search strategies impact

KataGo’s decision-making abilities when compared against perfect play. In our

research, we develop a larger Go endgame dataset labelled with perfect solutions,

and examine KataGo’s strengths and weaknesses through experiments

and analysis. We observe the effectiveness of strong policies in improving

move selection, the benefits and demerits of MCTS search enhancements, and

the challenges KataGo faces in competing against an exact solver. We further

analyse move choices by showing the changes of average action values,

lower confidence bound (lcb), winrate, and number of visited node according

to MCTS search in KataGo. KataGo has a 90.8% success rate while playing

matches against an exact solver in the perfect game dataset.
Cultural Memory in the Anthropocene: A Hypertext Narrative About Collecting
Creators: Morrow, Michaela
Publisher: name: University of Alberta Library
Year: 2024

This thesis takes the form of a hypertext, interactive game designed to be a thought experiment on cultural memory in the Anthropocene. It is a game, a form of research-creation, and a question. The question posed is simply: what cultural memories and memory objects do we make, forget, and reconfigure in the Anthropocene? It is a question for all “readers” of this project, and one whose answer will hopefully be informed by the narratives and research you find within this game. The thesis-game explores memories found in industrial waste, climate-change-induced traumas, ecological localities, and the memory systems that predate or will postdate our human-centered era. Most importantly, it explores nostalgia, fear, and hope in equal measure.
Supplementary document for Multi-material heterogeneous integration on a 3-D Photonic-CMOS platform [Invited] - 6594291.pdf
Creators: name: Ranno, Luigi
name: Sia, Jia Xu Brian
name: Dao, Khoi Phuong
name: Hu, Juejun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Information
Development of Chemical Isotope Labeling Liquid Chromatography Orbitrap Mass Spectrometry for Comprehensive Analysis of Di- and Tripeptides
Creators: Cheng, Zhan
Publisher: name: University of Alberta Library
Year: 2024

The study of small peptides, notably di- and tripeptides, has garnered significant attention for their potential in biological functions and as biomarkers in disease diagnosis. With 8,400 unique combinations possible from the 20 standard amino acids, their comprehensive analysis presents substantial hurdles in separation, detection, and quantification. This thesis aims to overcome these obstacles by leveraging sophisticated analytical methodologies, particularly the chemical isotope labeling liquid chromatography-mass spectrometry (CIL LC-MS) technique, to advance the analysis and profiling of di- and tripeptides. By innovating a method to detect and quantify all di- and tripeptides using CIL LC-MS combined with dansylation chemistry, this work achieves unparalleled coverage and accuracy.
Supplemental Material, DS1_VET_10.1177_0300985819833454 - Early Pulmonary Lesions in Cattle Infected via Aerosolized Mycobacterium bovis
Creators: name: Palmer, Mitchell V.
name: Wiarda, Jayne
name: Kanipe, Carly
name: Thacker, Tyler C.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, DS1_VET_10.1177_0300985819833454 for Early Pulmonary Lesions in Cattle Infected via Aerosolized Mycobacterium bovis by Mitchell V. Palmer, Jayne Wiarda, Carly Kanipe, and Tyler C. Thacker in Veterinary Pathology
The Regress and Ground of Being: In Defence of Metaphysical Infinitism
Creators: Oberle, Thomas
Publisher: name: University of Alberta Library
Year: 2024

There is a common intuition among many philosophers that chains of ground cannot go on forever. Metaphysical foundationalists believe that there cannot be infinite chains of ground, where one thing depends upon another for its existence without end. For example, if the existence of my desk depends upon the existence of its parts, and those parts depend upon further parts, etc., foundationalists think this regress must terminate in something fundamental. A prominent argument for why foundationalists think there cannot be infinite chains of ground says we must posit something fundamental to explain why there exist any non-fundamental or dependent things at all. The main idea is that if everything were dependent, then there would be no explanation for why any dependent things exist in the first place.

In this dissertation, I develop an argument for an opposing view to foundationalism called metaphysical infinitism. On this view, there is no end to chains of ground. For example, insofar as the existence of my desk depends upon the existence of its parts, and those parts depend for their existence upon further parts, this regress carries on indefinitely. According to metaphysical infinitism, nothing is fundamental. Everything is dependent upon something else.

I argue in favour of this thesis by defending a version of the Principle of Sufficient Reason (PSR). Broadly speaking, the PSR says that everything has a reason or explanation. My defense of the PSR is situated within the theoretical framework of grounding. According to the ground-theoretic version of the PSR that I defend, every fact has a ground or metaphysical explanation. I argue that the PSR entails metaphysical infinitism because if everything has a ground, then nothing is ungrounded or unexplained. As a result, nothing is fundamental, contrary to what the foundationalist believes. Since metaphysical foundationalism has arguably been the received view in analytic metaphysics, my dissertation seeks to challenge this consensus by providing a novel argument for an alternative position.
PPIs_in_SA_Bacteremia_Appendix – Supplemental material for Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia
Creators: name: Caffrey, Aisling R.
name: Timbrook, Tristan T.
name: Ali, Syed Raza
name: Nizet, Victor
name: Sakoulas, George
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, PPIs_in_SA_Bacteremia_Appendix for Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia by Aisling R. Caffrey, Tristan T. Timbrook, Syed Raza Ali, Victor Nizet and George Sakoulas in Therapeutic Advances in Gastroenterology
Two-Step Rigid and Non-Rigid Image Registration for the Alignment of Multi-View Three-Dimensional Echocardiography Sequences
Creators: Shanmuganathan, Srivathsan
Publisher: name: University of Alberta Library
Year: 2024

Ultrasound is a widely used imaging modality, which provides continuous real-time imaging of the human heart, brain, liver, and many other organs. Accurate cardiovascular evaluation plays an important role in early disease diagnosis and echocardiography plays an important role in the assessment of cardiovascular diseases. The lack of ionizing radiation and portability make echocardiography one of the safest imaging modalities. Although two-dimensional echocardiography is widely used to obtain the motion of the heart structures in real-time, real-time 3D echocardiography (RT3DE) imaging allows better 3D imaging by extracting spatial features along with temporal information, thus improving clinical decision making. There have been technological advances; however, the majority of acquired RT3DE images tend to be of low quality, characterized by the absence of anatomical information, decreased spatial and temporal resolution, speckle noise, and a limited field of view. By registering RT3DE images obtained from several sonography windows, it is possible to enhance the recognition of structures and achieve a substantial improvement in image quality as well as it is also useful in the fusion of echo images to image the entire heart.

This study proposes a fully automatic point-based rigid registration technique, followed by nonrigid B-spline registration, to align 4D echocardiogram images acquired from various sonographic windows. The methodology was evaluated using scans acquired from seven volunteers. The accuracy of registration was visually and quantitatively assessed by delineating the left ventricle in each scan and computing the Dice score overlap metric and the Hausdorff distance mutual proximity measure between the first scan and the rest. The overall findings demonstrate that the suggested registration method improves image alignment compared to the initial scans, which might be helpful in the fusion of echocardiographic images.
Supplementary document for Accurate modeling of ultrafast nonlinear pulse propagation in multimode gain fiber - 6594627.pdf
Creators: name: Chen, Yi-Hao
name: Haig, Henry
name: Wu, Yuhang
name: Ziegler, Zachary
name: Wise, Frank
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Mixing tree species and density management to reduce drought susceptibility in coastal plantation forests of British Columbia
Creators: Lukose, Surabhi
Publisher: name: University of Alberta Library
Year: 2024

The coastal forests of British Columbia have been experiencing longer and more intense

droughts in recent years. To evaluate the effects of species composition and density on

drought sensitivity, a study was conducted in a Douglas-fir:western redcedar plantation

established in 1992, in the eastern variant of the Coastal Western Hemlock very dry

maritime (CWHxm1) bio- geoclimatic subzone along the east side of Vancouver Island.

This plantation consists of a 4x3 factorial design with four different species mixtures

(Douglas-fir:western redcedar mixtures of 1:0, 1:1, 1:3, and 0:1) at three different planting

densities (500, 1000, and 1500 stems/ha). In summer 2022, measurements were taken to

evaluate soil moisture, drought tolerance and water use efficiency of these stands. Soil

moisture decreased with increasing stand density except for pure Douglas-fir stands which

had consistently low soil moisture at all densities. Drought indices calculated from tree

core data showed that drought resistance, resilience and recovery increased with

decreasing stand basal area. Wood carbon isotopic data indicated that western redcedar

trees in their pure stands had higher water use efficiency at lower basal area and these

trees were sensitive to drought compared to Douglas-fir trees. Douglas-fir benefitted when

mixed with Western redcedar and showed higher water use efficiency in mixed stands

compared to pure stands both during wet and dry years. In conclusion, reducing stand

basal area, which can be achieved by mixing the two species and controlling stand

density, can help reduce the drought susceptibility of these forests to long-term drought
Supplementary_Material_1 - Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in silico and in vitro study
Creators: name: DL Sheela
name: A Narayanankutty
name: PA Nazeem
name: AC Raghavamenon
name: SR Muthangaparambil
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplementary_Material_1 for Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in silico and in vitro study by DL Sheela, A Narayanankutty, PA Nazeem, AC Raghavamenon and SR Muthangaparambil in Human & Experimental Toxicology
Additional file 1 of Tea leaf-derived exosome-like nanotherapeutics retard breast tumor growth by pro-apoptosis and microbiota modulation
Creators: name: Chen, Qiubing
name: Zu, Menghang
name: Gong, Hanlin
name: Ma, Ya
name: Sun, Jianfeng
name: Ran, Susan
name: Shi, Xiaoxiao
name: Zhang, Jinming
name: Xiao, Bo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. Experimental details. Figure S1. Fluorescence imaging of cellular uptake profiles of DiO-TLNTs by 4T1 cells after co-incubation for 5 h. The scale bar represents 50 μm. Figure S2. Quantification of cellular uptake profiles of DiO-TLNTs by 4T1 cells. A Flow cytometric histograms, B cellular uptake percentages and the corresponding MFI values of 4T1 cells after co-incubation with DiO-TLNTs for 1, 3 and 5 h, respectively. Figure S3. Anti-migration capacities of TLNTs. A Migration profiles of 4T1 cells after co-incubation with TLNTs for 24 h. B Statistical analysis of migration behaviors of 4T1 cells receiving the treatment of TLNTs for 24 h. Each point represents the mean ± S.E.M. (n = 3; **p < 0.01). Figure S4. In vitro release profiles of fluorescence dye (DiO) from TLNTs in the stomach stimulating solution (pH 2.5) at 37 °C. Figure S5. Quantification of fluorescence intensities of tumor tissues and major organs at different time points after A i.v. injection and B oral administration. Data are expressed as mean ± S.E.M. (n = 3). Figure S6. Semiquantitative analysis of TUNEL signals of tumor tissues from various treatment groups. Data are expressed as mean ± S.E.M. (n = 3). Figure S7. Principle component analysis (PCA) of tumor genes from various mouse groups. Figure S8. Blood compatibility evaluation of TLNTs at various protein concentrations. A Digital photos and B hemolysis rates of erythrocytes receiving the treatment of TLNTs. Each point represents the mean ± S.E.M. (n = 3). Table S1. IC50 (μg/mL) of TLNTs against various tumor cell lines.
Appendix_1_STROBE_Statement – Supplemental material for Lithium treatment, nephrogenic diabetes insipidus and the risk of hypernatraemia: a retrospective cohort study
Creators: name: Ott, Michael
name: Forssén, Björn
name: Werneke, Ursula
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, Appendix_1_STROBE_Statement for Lithium treatment, nephrogenic diabetes insipidus and the risk of hypernatraemia: a retrospective cohort study by Michael Ott, Björn Forssén and Ursula Werneke in Therapeutic Advances in Psychopharmacology
Supplemental material for Barriers to receipt of novel oral oncolytics: A single-institution quality improvement investigation
Creators: name: Wang, Ann A
name: Tapia, Christopher
name: Bhanji, Yasin
name: Campbell, Christopher
name: Larsen, Daniel
name: Gross, Derick
name: Ganatra, Seema
name: Qodsi, Melad
name: Tellez, Claudia
name: Jain, Shikha
Publisher: name: SAGE Journals
Year: 2019
Subjects: Oncology and Carcinogenesis not elsewhere classified
Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental Material for Barriers to receipt of novel oral oncolytics: A single-institution quality improvement investigation by Ann A Wang, Christopher Tapia, Yasin Bhanji, Christopher Campbell, Daniel Larsen, Derick Gross, Seema Ganatra, Melad Qodsi, Claudia Tellez and Shikha Jain in Journal of Oncology Pharmacy Practice
Supplemental Material, MRX832235_Supplemental_Appendix - Second-Generation Contextual Mobility: Neighborhood Attainment from Birth to Young Adulthood in the United States
Creators: name: Tran, Van C.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, MRX832235_Supplemental_Appendix for Second-Generation Contextual Mobility: Neighborhood Attainment from Birth to Young Adulthood in the United States by Van C. Tran in International Migration Review
Supplemental material for Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection
Creators: name: Ringleb, Peter
name: Bendszus, Martin
name: Bluhmki, Erich
name: Donnan, Geoffrey
name: Eschenfelder, Christoph
name: Fatar, Marc
name: Kessler, Christof
name: Molina, Carlos
name: Leys, Didier
name: Girish Muddegowda
name: Poli, Sven
name: Schellinger, Peter
name: Schwab, Stefan
name: Joaquin Serena
name: Toni, Danilo
name: Wahlgren, Nils
name: Hacke, Werner
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: Cardiology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental Material for Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection by Peter Ringleb, Martin Bendszus, Erich Bluhmki, Geoffrey Donnan, Christoph Eschenfelder, Marc Fatar, Christof Kessler, Carlos Molina, Didier Leys, Girish Muddegowda, Sven Poli, Peter Schellinger, Stefan Schwab, Joaquin Serena, Danilo Toni, Nils Wahlgren, Werner Hacke and for the ECASS-4 study group in International Journal of Stroke
Probing thermal dissipation dimensionality to laser ablation in the pulse duration range from 300 fs to 1 μs.pdf
Creators: name: Endo, Tsubasa
name: Tani, Shuntaro
name: Sakurai, Haruyuki
name: Kobayashi, Yohei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental 1