cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Erfahrungswissen auf Reisen
title: eine ethnographische Untersuchung zum kommunikativen Umgang mit Menschen mit diagnostizierten Autismus-Spektrum-Störungen
titleType: AlternativeTitle
Creators: name: Nowodworski, Pao
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: Autismus-Spektrum-Störungen
subject: Erfahrungswissen
subject: Lebensweltanalyse
subject: Ethnographie
subject: 300
subject: Autismus
subject: Ethnologie
subject: Kommunikation

description: Die eingereichte Dissertation „Erfahrungswissen auf Reisen. Eine ethnographische Untersu-chung zum kommunikativen Umgang mit Menschen mit diagnostizierten Autismus-Spektrum-Störungen“ ist eine soziologische Ethnographie des kommunikativen Umgangs mit der medi-zinischen Kategorie Autismus-Spektrum-Störungen (kurz: ASS). Zentral geht es um die Be-antwortung der Frage, welches Wissen, welche Deutungsmuster und welche Handlungsstrate-gien involvierte Expert*innen aus den Bereichen Familie, Pflege, Betreuung und Therapie her-anziehen, um mit Menschen mit der Diagnose ASS umzugehen. Dabei wird insbesondere ein Fokus auf die Rolle von Erfahrungswissen gelegt und das Verhältnis dieser Wissenskategorie innerhalb und zwischen involvierten Feldern untersucht. Zudem werden Fremdheits- und Ver-trautheitsbilder über den Umgang mit ASS auf Basis subjektorientierter Analysen rekonstru-iert. Der theoretische Unterbau der Arbeit folgt einem wissenssoziologischen Verständnis mit handlungstheoretischer Ausrichtung. Zur empirischen Erhebung subjektiver Perspektiven in unterschiedlichen Feldern wird eine Kombination aus einer Lebensweltanalytischen Ethnogra-phie und Multi-Sited Ethnography durchgeführt. Die Phänomenologie und die wissenssozio-logische Hermeneutik dienen dabei als Auswertungsmethoden. Im Hauptteil der Arbeit wer-den Fallanalysen der Forschungsfelder Familie, Pflege, Betreuung und Therapie durchgeführt. Dabei werden die feldinternen Handlungstypen und Gewissheiten kleiner Lebenswelten re-konstruiert. Die Entwicklung individuell zugeschnittener Handlungsstrategien, deren Hand-lungsentwürfe in einen objektivierbaren Handlungszusammenhang aller Felder gesetzt werden kann, beschreibt eine zentrale Erkenntnis der Dissertation, die in der Ergebnisdiskussion näher erläutert wird.
The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer
Creators: name: Malsy, Manuela
name: Graf, Bernhard
name: Almstedt, Katrin
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: TUMOR-NECROSIS-FACTOR; C-FOS; MOLECULAR-BIOLOGY; TOLFENAMIC ACID; FACTOR FAMILY; GROWTH; NFAT; EXPRESSION; OVEREXPRESSION; PROGRESSION; Sp1; NFATc2; Pancreatic cancer; Binding partner; Cancer; C-terminus; N-terminus; Proliferation
subject: 610 Medizin

description: BackgroundAdenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly characterized by extremely rapid growth triggered by the activation of oncogenic signaling cascades, which suggests a change in the regulation of important transcription factors. Amongst others, NFAT transcription factors are assumed to play a central role in the carcinogenesis of pancreatic cancer. Recent research has shown the importance of the transcription factor Sp1 in the transcriptional activity of NFATc2 in pancreatic cancer. However, the role of the interaction between these two binding partners remains unclear. The current study investigated the role of Sp1 proteins in the expression of NFATc2 target genes and identified new target genes and their function in cells. A further objective was the domain of the Sp1 protein that mediates interaction with NFATc2.The involvement of Sp1 proteins in NFATc2 target genes was shown by means of a gene expression profile analysis, and the results were confirmed by quantitative RT-PCR. The functional impact of this interaction was shown in a thymidine incorporation assay. A second objective was the physical interaction between NFATc2 and different Sp1 deletion mutants that was investigated by means of immunoprecipitation.ResultsIn pancreatic cancer, the proto-oncogene c-Fos, the tumor necrosis factor TNF-alpha, and the adhesion molecule integrin beta-3 are target genes of the interaction between Sp1 and NFATc2. Loss of just one transcription factor inhibits oncogenic complex formation and expression of cell cycle-regulating genes, thus verifiably decreasing the carcinogenic effect. The current study also showed the interaction between the transcription factor NFATc2 and the N-terminal domain of Sp1 in pancreatic cancer cells. Sp1 increases the activity of NFATc2 in the NFAT-responsive promoter.ConclusionsThe regulation of gene promotors during transcription is a rather complex process because of the involvement of many proteins that - as transcription factors or co-factors - regulate promotor activity as required and control cell function. NFATc2 and Sp1 seem to play a key role in the progression of pancreatic cancer.
Cueta lineosa
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Cueta
Cueta lineosa

description: Cueta lineosa (Rambur, 1842)
(Figs. 2D, 23)
The larvae are insufficiently known. Lackinger (1973) simply compared the proportions of head of this species with M. trigrammus, while the description of Mirmoayedi (2002) is excessively concise, even insufficient to discriminate it from other antlions.
Examined specimens. Greece. Rhodos, Vati, grassland, VII.2009 (D. Badano), 1 L3. Rhodos, Tsambika, back dune, VII.2009 (D. Badano), 1 L3.
Description of 3 rd instar larva. Size (based on 2 specimens): BL 8.75 mm; HL 1.85 mm (1.82–1.87), HW (1.37–1.45), ML 1.70 mm (1.67–1.72), HW/HL 0.76, ML/HL 0.92. General colouring light brown with brown pattern, ventral side pale ochre with contrasting dark markings; head capsule dark brown with a paler V-shaped anterior marking and a median pale stripe, lateral side with extensive markings, ventral side of the head paler with a distinctive median pair of elongated markings (Fig. 23c); mandibles pale brown, darker toward the tip; legs pale; setae of the body black. Head longer than wide, relatively small in comparison to the body; mandibles almost as long as the head capsule; median and apical teeth spaced by setae (Fig. 23a); interdental mandibular setae (~8)(2– 3)(1)(1very small); dorsal side of the mandibles covered by few short setae, ventral side with sparse and short setae, lateral side with a fringe of setae (Fig. 23b). Mesothoracic spiracles dark brown. VIII sternite provided with very small odontoid processes, posterior margin equipped with large and stout digging setae, the internal pairs are the largest and grouped on protuberances; IX sternite with two pairs of stout digging setae and two rastra each bearing 4 digging setae with a large seta at their base (Figs. 2D, 23d).
Bio-ecology. C. lineosa is associated with open and arid environments such as scrublands, steppes or even deserts. The larvae were collected in back dunes with sparse vegetation and in dry grasslands.
Distribution. Widespread in arid areas of North Africa and Eurasia.
Remarks. The larva of C. lineosa is notable for the presence in the mandibles of 1 seta, though very short and easily overlooked, after the apical tooth; this character is normally typical of the tribe Myrmeleontini.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on pages 44-47, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Taxing high and paying low - essays on German fiscal policy between the wars
Creators: name: Steinbrecher, Hendrik
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: Macroeconomics
subject: Fiscal policy
subject: Public finance
subject: Fiscal history 1925-39
subject: Multiplier
subject: Taxation
subject: Public job creation
subject: 330
subject: Deutschland
subject: Geschichte 1918-1933
subject: Weimarer Republik
subject: Zwischenkriegszeit
subject: Fiskalpolitik
subject: Beschäftigungspolitik

description: This thesis examines the employment and tax multipliers of German fiscal policy between the World Wars. Chapter 1 offers an introductory overview. Chapter 2 estimates the regional job multipliers of public job creation schemes financed by the German unemployment insurance between 1933 and 1937. The financial outlay associated with one year of employment in these programmes was found to be 706 RM, a figure that is marginally higher than the rate of unemployment benefits but represents approximately half the average annual wage at the time. The limited additional income generated in comparison to unemployment leaves scant evidence of second-round multiplier effects. Expansionary employment effects were largely limited to the scope of the Nazi programmes themselves. The following two chapters present a qualitative analysis of changes to tax law and a quantitative analysis of the macroeconomic effects of tax changes in the German interwar period. For econometric identification, Chapter 3 develops a novel narrative dataset of tax law changes between 1925 and 1939 and isolates exogenous variation in fiscal policy based on their underlying motivations. In this comprehensive historical account, each amendment is contextualised and supplemented with projected revenue changes using archival material. Chapter 4 addresses the estimation of tax multipliers utilising the previously developed data set. The sign and level of the multiplier are contingent upon whether Brüning's austerity policy between 1930 and 1932 is classified as exogenous or endogenous. Assuming endogeneity, the multiplier takes on a value of up to 2.5, indicating non-standard evidence as a tax increase is associated with an expansionary effect. Conversely, if one adheres to the reasoning of the Borchardt debate and assumes exogeneity for these measures, the standard evidence of an inverse relationship is restored, with the multiplier peaking at -1.5. Finally, Chapter 5 draws implications for academic discourse in economics and history.
Capsule rheology and machine learning
Creators: name: Kratz, Felix Sebastian
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: Rheology
subject: Capsule
subject: Interfaces
subject: Bending
subject: Elasticity
subject: Contact
subject: Traction force
subject: 530

description: apsules and their properties have provoked an increasing interest in several fields of the sciences and industry. In the sciences, several relevant biological system are modeled as a liquid core encapsulated by a skin of some sort, e.g. red blood cells. In industry, capsules are usually used the other way around -- not to model nature, but rather to design for functionality, e.g. in medical application or the food industry. Given their ubiquitous application, we discuss and investigate the solution of shape equations for freely pendant droplets, capsules and derive a method to incorporate viscous dissipation for time dependent deformation sequences. These theoretical investigations are supplemented with a novel numerical framework which allows us to solve the shape equations, fit them to experimental images, and therefore infer information from experiments. We apply the theoretical and numerical insights gained during the course of this work to investigate the properties of complex interfaces, such as multi-layer systems. While an individual capsule has interesting applications, the reality often is that a capsule can not be isolated from other capsules or some constraining boundaries. We therefore investigate -- for the first time in literature -- the contact problem of a pressurized, bending-stiff, adhesive, elastic capsule under an external force both with a solid wall and with another capsule of this kind. The resulting shape equations give us access to the shape-parameter diagram and allow us to understand the contact problem without performing any experiment. We rather integrate the shape equations numerically and find the solutions nature realizes, together with all relevant derived quantities, such as the contact force. Additionally, we design a meta-material (theoretically) from an elastic capsule unit-cell by extending the contact theory to a columnar structure. Several problems encountered in physics, especially in inverse problems, can be considered ill-conditioned. An ill-conditioned problem reacts sensitive to perturbations of the input data and usually needs to be regularized or otherwise constrained to produce stable predictions or results. In this thesis we explore the potential of machine learning approaches for exactly this task. With liquid droplet and elastic capsule shape fitting, as well as traction force microscopy, as example problems, we convincingly show that machine learning approaches for these ill-conditioned problems are suitable and outperform conventional methods by orders of magnitude in speed, allowing for a entirely new applications.
Esperanta Kurso : per esperanto, por esperanto, por labora klaso (p. 3)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Dua leciono
Dinaromys bogdanovi
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Dinaromys
Dinaromys bogdanovi

description: Dinaromys bogdanovi (Martino 1922)
[Dolomvs] grebenscikovi Martino 1922, Ann. Mag. Nat. Hist., ser. 9, 9: 413.
Type Locality: W Serbia and Montenegro, Rijeka Prov., Montenegro, Cetinje.
Vernacular Names: Balkan Snow Vole.
Synonyms: Dinaromys coeruleus Miric 1960; Dinaromys grebenscikovi (Martino 1935); Dinaromys korabensis (Martino 1937); Dinaromys longipedis Dulic and Vidimic 1967; Dinaromys marakovici (Bolkay 1924); Dinaromys preniensis (Martino 1940); Dinaromys trebevicensis Gligic 1959.
Distribution: Isolated pockets in karst mountains, sea level to 2200 m, of W Balkans—Dinaric Alps in Croatia, Bosnia and Herzegovina, Montenegro and Kosovo; and the Šara-Pindus Mtns of Macedonia; probably occurs in Albania and Greece.
Conservation: IUCN – Lower Risk (nt).
Discussion: Petrov (1992) and Mitchell-Jones et al. (1999) provided informative reviews. Zoogeographic aspects discussed by Petrov (1979); distribution in Montenegro and its zoological significance reported by Kryštufek and Vohralík (1992). Chromosomal data presented by Zima and Kral (1984 a) and Zima et al. (1997 a). Eight subspecies have been recognized, forming two groups that are distinguished by M1 patterns and genetic divergence (Mitchell-Jones et al., 1999); Kryštufek et al. (2000 b) provided information on age determination and molar structure. The extant species is closely related to two Pleistocene species— D. dalmatinus from N Italy, Serbia and Montenegro, and S Greece (Petrov and Todorovic, 1982) and D. topachevskii from Uzbekistan (Nesin and Skorik, 1989)—and to the late Pliocene D. allegranzii from NE Italy (Sala, 1996). Middle Pleistocene fossils of D. bogdanovi in N Italy (Zanalda, 1994) underscore the relictual character of the modern range.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 974, DOI: 10.5281/zenodo.7316535
title: Lettre n°1301 de Paul d'Estournelles de Constant à Nicholas Murray Butler (13 avril 1923)
title: Letter number 1301 from Paul d'Estournelles de Constant to Nicholas Murray Butler (April 13, 1923)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Guerre mondiale (1914-1918)
Pacifisme

description: Source: Archives de la Sarthe – France
"zpt_y3_y1.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 1.2 < |y| < 1.6 and 0.4 < |y| < 0.8
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Nocebo effects and negative suggestions in daily clinical practice – forms, impact and approaches to avoid them
Creators: name: Hansen, Ernil
name: Zech, Nina
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: physician-patient communication, Informed Consent, Nocebo effects, Therapeutic communication, nonverbal suggestions, natural trance, Negations
subject: 610 Medizin

description: Doctors not merely observe and describe symptoms and side effects, but influence and even induce them through their communication. In fact, a significant portion of them originate from health care providers via nocebo effects and not from drugs or surgery. Many signals in medical situation perceived by patients have unintentional negative effects by omission of placebo effects, talking in negations, nocebo effects following negative expectations, by negative suggestions and missing therapeutic relationships. Instead, every treatment should be accompanied by words. In addition to information meaning should be expressed. Meaning and positive expectations can also be raised aside from interventions by addressing the basic psychological needs and avoiding known traumatic stressors.
A method to neutralize negative expectations is the introduction of alternative possibilities, which reduces the probability of the expected bad outcome. A promising strategy to avoid nocebo effects in informed consent is to always provide risk information together with positive aspects like advantages of the offered therapy, the prophylactic measures to reduce risks, the monitoring for early detection of developing side effects, the prevention of harm by early therapy, and the patient`s own possible contribution to risk reduction. Negative expectations can be recognized by the word “always…” used by a patient when describing complaints. They can be neutralized by verbal mirroring with change of the word “always” to ”often” or “in the past”, thereby shifting focus to exceptions and solutions, and leaving the future undetermined to negative outcome.
Apart from inducing expectations, suggestions have inherent effects, especially in medical situations that commonly induce a natural trance state with enhanced attention, self-reference and increased suggestibility. Talking in negations and attempts to neutralize negative words by negation or diminutives achieve the opposite. Many non-verbal suggestions like overhead induction of anesthesia, transport in not indicated strict supine position, and top-down communication add to anxiousness and stress. Further causes of negative effects are misunderstandings, uncertainties, lies, enforcement of passivity and unmatched levels of communication.
A major determinant of the harm of negative suggestions or the effectiveness of positive therapeutic communication is the context of the individual patient`s predispositions and of the doctor-patient relationship.
Acanthaclisini Navas 1912
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae

description: Tribe Acanthaclisini Navás, 1912
Diagnosis of 3 rd instar larva. Head capsule without prominent ocular tubercles; mandibles equipped from one to three teeth; labial palpi four-articulated, segments 2–4 shorter than the basal width of the mandible. Mesothoracic spiracles sessile. Thorax and abdomen with sessile setiferous processes. Legs with a fringe of setae. VIII abdominal sternite without odontoid processes; IX abdominal sternite bearing digging setae but without rastra.
Biological notes. The larvae of this tribe are not pit-building antlions able to move both forward and backward; some genera are characterized by the ability to move only backward.
Comments. This distinctive and widespread tribe is comparatively the better known one in the family regarding the larval stages, thanks to the review of Stange & Miller (1985).
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 47, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Ellobius G. Fischer 1814
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Ellobius

description: Ellobius G. Fischer 1814
Ellobius G. Fischer 1814, Zoognosia, Vol. 3: 72.
Type Species: Mus talpinus Pallas 1770
Synonyms: Afghanomys Baryshnikov and Baranova 1983; Chthonergus Nordmann 1839; Lemmomys Lesson 1842.
Species and subspecies: 5 species in 2 subgenera:
Subgenus Ellobius (Ellobius) G. Fischer 1814
Subgenus Ellobius (Afganomys) Topachevski 1965
Species Ellobius (Ellobius) alaicus Vorontsov et al. 1969
Species Ellobius (Afganomys) fuscocapillus Blyth 1843
Species Ellobius (Afganomys) lutescens Thomas 1897
Species Ellobius (Ellobius) talpinus (Pallas 1770)
Species Ellobius (Ellobius) tancrei Blasius 1884
Discussion: Ellobiusini (emended by Pavlinov et al., 1995 a, because Ellobiini Gill 1872 is a junior homonym of Ellobiinae Adams, 1858, whose type genus Ellobium is a mollusk). Gromov and Polyakov (1977) excluded Ellobius from arvicolines; Pavlinov and Rossolimo (1987) viewed the genus as Cricetidae incertae sedis, questioning whether it belonged in Arvicolinae or Cricetinae; and Gromov and Erbajeva (1995) included it in Cricetinae. Most workers, however, have recognized Ellobius, albeit highly specialized morphologically, as the only extant member of a tribe within Arvicolinae (Corbet, 1978 c; Hooper and Hart, 1962; Kretzoi, 1969; McKenna and Bell, 1997; Pavlinov and Rossolimo, 1998; Pavlinov et al., 1995 a; Topachevskii and Rekovets, 1982), an affiliation supported by DNA sequence (Just et al., 1995) and allozymic analyses (Mezhzherin et al., 1995). Ultrastructure and evolution of sex chromosomes discussed by Kolomiets et al. (1991). Two subgenera are recognized, Ellobius and Afganomys; Zagorodnyuk (1990) listed the latter as a genus. Topachevskii and Rekovets (1982) documented morphological trends and interspecific interpretations from the late Pliocene to Recent. The present range of Ellobius is only part of a wider distribution that once embraced Israel and North Africa in the middle to late Pleistocene (Jaeger, 1988 a).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 974, DOI: 10.5281/zenodo.7316535
Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA
Creators: name: Boscheinen, Jan B.
name: Thomann, Sabrina
name: Knipe, David M.
name: DeLuca, Neal
name: Schuler-Thurner, Beatrice
name: Gross, Stefanie
name: Dörrie, Jan
name: Schaft, Niels
name: Bach, Christian
name: Rohrhofer, Anette
name: Werner-Klein, Melanie
name: Schmidt, Barbara
name: Schuster, Philipp
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: PLASMACYTOID DENDRITIC CELLS; CYTOTOXIC T-LYMPHOCYTES; IMMUNE-RESPONSES; LYMPH-NODES; ANTIGEN; VACCINE; IDENTIFICATION; MONOCYTES; GENOME; TYPE-1; vaccine; oncolytic viruses; malignant melanoma; herpes virus; cytotoxic T cell response
subject: 610 Medizin

description: Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) d 106S. To combine this innate effect with an enhanced adaptive immune response, the gene encoding human MelanA/MART-1 was inserted into HSV-1 d 106S via homologous recombination to increase direct expression of this tumor antigen. Infection of Vero cells using this recombinant virus con firmed MelanA expression by Western blotting, flow cytometry, and immuno fluorescence. HSV-1 d 106S-MelanA induced expression of the transgene in fibroblast and melanoma cell lines not naturally expressing MelanA. Infection of a melanoma cell line with CRISPR-Cas9-mediated knockout of MelanA con firmed de novo expression of the transgene in the viral context. Dependent on MelanA expression, infected fibroblast and melanoma cell lines induced degranulation of HLA-matched MelanA-specific CD8(+) T cells, followed by killing of infected cells. To study infection of immune cells, we exposed peripheral blood mononuclear cells and in vitro-differentiated macrophages to the parental HSV-1 d 106S, resulting in expression of the transgene GFP in CD11c(+) cells and macrophages. These data provide evidence that the application of MelanA-encoding HSV-1 d 106S could enhance adaptive immune responses and re-direct MelanA-specific CD8(+) T cells to tumor lesions, which have escaped adaptive immune responses via downregulation of their tumor antigen. Hence, HSV-1 d 106S-MelanA harbors the potential to induce innate immune responses in conjunction with adaptive anti-tumor responses by CD8(+) T cells, which should be evaluated in further studies.
Scoparia juldusellus
Creators: name: Sinev, Sergey Yu.
name: Korb, Stanislav K.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Crambidae
Scoparia
Scoparia juldusellus

description: Scoparia juldusellus (Caradja, 1916)
Caradja (1916: 4) (Crambus); Błeszyński (1962: 2) (comb. n.); Popescu-Gorj (1991: 166) (lectotype designation).
Material. 2 ♂, 27–28.07[VII].2019, Kyrgyzstan, Talas Mts, Kara-Buura River valley, 31 km S of Kluchevka, 1707 m, 42.337976°N, 71.60727°E, leg. S. K. Korb; 1 ♂, 9–11.07[VII].2019, Kyrgyzstan, Baidulu Mts, Dolon Pass, 2818 m, 41.825756°N, 75.785590°E, leg. S. K. Korb. One specimen is housed in the collection of the Zoological Institute, Russian Academy of Sciences (St. Petersburg, Russia), and two, in the collection of S. K. Korb (Bishkek, Kyrgyzstan).
Redescription. Male (figs 1, 2). Forewing length 10–11 mm. Head (including antennae and labial palpi), thorax (including legs) and abdomen colored as forewing. Eyes dark-brown, glabrous. Labial palpi twice longer than eyes in frontal view, antennae shorter than forewing length. Forewings upperside whitish-cream or whitish-yellow with slightly darker blurred submarginal line and small distinct brownish dot on discal vein. Hindwing slightly lighter than forewing, with slightly darker median band and slightly darker marginal border. Underside of both wings of same color and pattern as upperside. Fringes whitish-yellow.
Female unknown.
Male genitalia (figs 3, 4). Uncus triangular. Gnathos narrow and straight, longer than uncus, with pointed apex. Saccus massive, trapezoid. Valva wide, oblong-oval, with narrowly sclerotized dorsal margin; widely sclerotized sacculus with long and protruding acicular process apically. Aedeagus straight, slightly curved in its basal part, with single cornutus in form of long and heavily sclerotized thorn. Juxta thin, bilobed, C-shaped.
Variation. The specimen from West Tian-Shan (fig. 1) is darker, with larger discal dot; the Inner Tian-Shanian one (fig. 2) is lighter, with more indistinct wing pattern. There are no differences in male genitalia between these specimens.
Biology. The species had been collected at light in two different river valleys: at the altitude about 2800 m in the dry stony meadow slopes without bushes in Inner Tian-Shan (fig. 5) and at the altitude about 1700 m in the dry stony steppe slopes with bushes in West Tian-Shan (fig. 6).
Distribution (fig. 7). To date, the species was known only from its type locality. Our data enlarged its area significantly, now it is known also from Talas Mts (Kara-Buura River) in West Tian-Shan and from Baidulu Mts (Dolon Pass) in Inner Tian-Shan (Kyrgyzstan). We can assume its wider distribution in the montane areas of Central Asia.
description: Published as part of Sinev, Sergey Yu. & Korb, Stanislav K., 2022, Scoparia juldusellus (Caradja, 1916), a little-known snout moth species new to the fauna of Kyrgyzstan (Lepidoptera: Crambidae: Scopariinae), pp. 597-600 in Zootaxa 5125 (5) on pages 597-599, DOI: 10.11646/zootaxa.5125.5.11, http://zenodo.org/record/6457242
Annotation on P.Med inv. 195.
Creators: name: Daris, Sergio
name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 3
description: Annotations, two descriptions with transcriptions, bibliographical references. - Index of «Papiri della università degli studi di Milano», 2 (1961). - Letters from Sergio Daris (1969, 1985).
description: Source: 4MAR_20_3.2-13
description: Relation: Sergio Daris
description: Coverage: Trieste
description: created: n. d., November 1969, September 1985
Untersuchung zum Einfluss des thermomechanischen Belastungskollektivs auf die Oberflächenkonditionierung beim BTA-Tiefbohrprozess
Creators: name: Schmidt, Robert
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: BTA-Tiefbohren
subject: Surface integrity
subject: Prozessschwingungen
subject: 620
subject: 670
subject: BTA-Tiefbohren
subject: Maschinenelement
subject: Vergütungsstahl
subject: Nicht rostender Stahl
subject: Werkstückrandzone
subject: Fertigung
subject: Modellierung
subject: Schwingungsverhalten
subject: Produktionstechnik
subject: Thermomechanische Belastung
subject: Werkstoffprüfung

description: Die moderne Produktionstechnik strebt ökonomische Effizienz und Nachhaltigkeit an, ohne die Qualität der gefertigten Bauteile zu beeinträchtigen. Die Auswahl und Anpassung von Fertigungsprozessen und die damit einhergehende Erzeugung relevanter Randschichteigenschaften ist entscheidend. Der BTA-Tiefbohrprozess ist ein produktives Verfahren zur Fertigung tiefer Bohrungen mit großen Durchmessern. Das BTA-Tiefbohren ist ein wichtiger Bearbeitungsschritt für die Fertigung hochbelasteter und sicherheitsrelevanter Bauteile wie z.B. Flugzeuglandebeine, Kurbelwellen und Schwerstangen in der Offshore-Industrie. Nach dem Bohrprozess kommt es häufig zu einer Nachbearbeitung der Bohrungsoberfläche, ohne dass der initiale Randschichtzustand bekannt ist. Eine optimierte Bohrprozessauslegung kann die Produktionskette an dieser Stelle verkürzen. In dieser Arbeit wird die Oberflächenkonditionierung durch den BTA-Tiefbohrprozess in einem Vergütungsstahl und einer nichtrostenden austenitischen Stahllegierung untersucht. Zur Separierung der Konditionierungsmechanismen an den Wirkelementen des BTA-Werkzeugs wurde ein Analogieversuch entwickelt. Während der BTA-Experimente wurden sowohl werkzeug- als auch werkstückseitige Messmethoden eingesetzt, um das thermomechanische Belastungskollektiv zu erfassen. In Verbindung mit zerstörenden und nicht zerstörenden Messungen der Bohrungsrandzonen wurde die Prozess-Struktur-Eigenschafts-Beziehung beschrieben. Ein analytisches Modell zur Berechnung der resultierenden Oberflächenkonditionierung wurde entwickelt, basierend auf der 3D Schneiden- und Führungsleisteneingriffsmodellierung in Verbindung mit der Eigendehnungstheorie. Zudem wurden charakteristische Prozessschwingungen analysiert und in Verbindung mit den entstehenden Oberflächenmarken gebracht, wodurch ein bestehendes Dynamikmodell erweitert werden konnte.
description: Schriftenreihe des ISF;112
Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis
Creators: name: Schröder, Agnes
name: Nazet, Ute
name: Muschter, Dominique
name: Grässel, Susanne
name: Proff, Peter
name: Kirschneck, Christian
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: SERUM HYALURONIC-ACID; RHEUMATOID-ARTHRITIS; PROTEOGLYCAN DEGRADATION; ARTICULAR CHONDROCYTES; GENE-EXPRESSION; TNF-ALPHA; CARTILAGE; JOINT; INFLAMMATION; RECEPTOR; osteoarthritis; synovial fibroblasts; mechanical loading; synovium; inflammation; synovitis; compressive force
subject: 610 Medizin

description: Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (OA-SF). We treated N-SF and OA-SF with or without mechanical loading for 48h after 24h of preincubation. Then we assessed gene and protein expression of proinflammatory factors (TNF, COX-2, PG-E2, IL-6), extracellular matrix (ECM) components (COL1, FN1) and glycosaminoglycans (GAGs) via RT-qPCR, ELISA, DMMB assay and HPLC. Mechanical loading significantly increased TNF and PG-E2 secretion by N-SF and OA-SF, whereas in OA-SF IL-6 secretion was reduced. COL1 and FN1 secretion were downregulated in N-SF during loading. OA-SF secreted less COL1 compared to N-SF under control conditions. In contrast, OA-SF in general expressed more FN1. GAG synthesis was upregulated in N-SF, but not in OA-SF during loading with OA-SF displaying a higher charge density than N-SF. Mechanical loading enhanced proinflammatory factor expression and GAG synthesis and decreased secretion of ECM components in N-SFs, indicating a contributing role of SF to OA development.
In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats
Creators: name: Bitzinger, Diane I.
name: Gruber, Michael
name: Tümmler, Simon
name: Malsy, Manuela
name: Seyfried, Timo
name: Weber, Florian
name: Redel, Andreas
name: Graf, Bernhard M.
name: Zausig, York A.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: SERUM-CHOLINESTERASE; IMPROVES SURVIVAL; SEPTIC SHOCK; INHIBITION; INJURY;
subject: 610 Medizin

description: Introduction. Recent studies have shown that acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may serve as important diagnostic and therapeutic targets in sepsis. Since polymorphonuclear neutrophils (PMNs) play a pivotal role in the early phase of sepsis, we evaluated the potential therapeutic effects of cholinesterase inhibitors on PMN functions during cecal ligation and puncture- (CLP-) induced sepsis and investigated the roles of AChE and BChE as inflammatory markers under standardized experimental conditions. Methods. Sham surgery or CLP was performed in male Wistar rats (n = 60). Animals were randomized into four groups: physostigmine, 100 mu g/kg; neostigmine, 75 mu g/kg; 0.9% saline (control group); and sham group, each applied four times over 24 h. The levels of reactive oxygen species (ROS) production and CD11b/CD62l expression were quantified by flow cytometry at t = 0, 6, 15, 20, and 24 h. Blood gas analysis as well as AChE and BChE activity levels was measured by validated point-of-care measurements. Clinical scores and survival times were determined. Results. CLP induced a significant increase in ROS production and CD11b upregulation by rat PMNs. Treatment with physostigmine or neostigmine significantly reduced ROS production and CD11b upregulation by PMNs 20 h after CLP induction. In physostigmine-treated animals, survival times were significantly improved compared to the control animals, but not in neostigmine-treated animals. While AChE activity significantly decreased in the control animals at t > 6h, AChE activity did not change in the sham group. BChE activity decreased at t > 20h in the control animals. Conclusion. While AChE activity may serve as an acute inflammatory marker, BChE activity shows a delayed decrease. Administration of centrally acting physostigmine in CLP-induced sepsis in rats has protective effects on PMN functions and improves survival times, which may be of interest in clinical practice.
The Importance of Physioxia in Mesenchymal Stem Cell Chondrogenesis and the Mechanisms Controlling Its Response
Creators: name: Pattappa, Girish
name: Johnstone, Brian
name: Zellner, Johannes
name: Docheva, Denitsa
name: Angele, Peter
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: mesenchymal stem cells; chondrogenesis; hypoxia; cartilage; hypertrophy; hypoxia inducible factors; early osteoarthritis
subject: 610 Medizin

description: Articular cartilage covers the surface of synovial joints and enables joint movement. However, it is susceptible to progressive degeneration with age that can be accelerated by either previous joint injury or meniscectomy. This degenerative disease is known as osteoarthritis (OA) and it greatly affects the adult population. Cell-based tissue engineering provides a possible solution for treating OA at its earliest stages, particularly focal cartilage lesions. A candidate cell type for treating these focal defects are Mesenchymal Stem Cells (MSCs). However, present methods for differentiating these cells towards the chondrogenic lineage lead to hypertrophic chondrocytes and bone formation in vivo. Environmental stimuli that can stabilise the articular chondrocyte phenotype without compromising tissue formation have been extensively investigated. One factor that has generated intensive investigation in MSC chondrogenesis is low oxygen tension or physioxia (2–5% oxygen). In vivo articular cartilage resides at oxygen tensions between 1–4%, and in vitro results suggest that these conditions are beneficial for MSC expansion and chondrogenesis, particularly in suppressing the cartilage hypertrophy. This review will summarise the current literature regarding the effects of physioxia on MSC chondrogenesis with an emphasis on the pathways that control tissue formation and cartilage hypertrophy.
IDENTIFYING THE ORGANIZERS OF THE GSM STANDARD'S GENERAL NETWORK SCHEME
Creators: name: Alimardonov, Shoxruh
Publisher: name: Zenodo
Year: 2025

description: This article explains in detail the main components of the GSM mobile communication network, their principles of interaction, authentication processes and the functions of various centers (HLR, VLR, EIR, OMS, NMC). The article presents the composition of long-term and temporary data stored in the HLR (Home Location Register) and VLR (Visitor Location Register) systems. It also covers how subscriber information is stored in the network, how it is updated depending on the location of mobile stations, and the authentication and encryption processes. The article also provides complete information on the important roles that network management systems, including OMS and NMC, play in ensuring their effective operation. The principles of interaction of these elements and their impact on other elements in the system are explained.
title: La Araucana...
Creators: name: de Ercilla y Zuniga, Alonso
name: Sancha, A. De. Imprimeur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 2 vol
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Liber, Mt p 1819
Shrinking cities through a cultural kaleidoscope: how participatory culture drives collaborative governance?
Creators: name: Matyushkina, Anastasiya
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Shrinking cities
subject: Urban governance
subject: Culture-led regeneration
subject: Cultural policy
subject: Collaborative governance
subject: Co-production
subject: 710
subject: Stadtplanung
subject: Stadtverwaltung
subject: Kulturpolitik

description: This thesis expands the understanding of urban culture's role in the governance of shrinking cities, based on case studies in Riga and Oberhausen. It moves beyond the traditional view of urban culture as merely a tool for economic and physical regeneration, highlighting its importance for urban governance. A typology is introduced, categorizing urban culture into institutional, traditional (folklore), and participatory forms. The latter shows the greatest potential for local governments to foster community development, strengthen civil society, and improve interdepartmental communication. However, participatory culture must first be recognized by local governments, especially those in strategic departments. Strong formal institutions, such as sociocultural centers or cultural NGOs, are essential for its integration into governance. Collaborative networks between local governments and third-sector organizations are vital, offering mutual support and sustainability, particularly in resource-constrained environments. The findings offer recommendations for shrinking cities, suggesting that culture provides a wide range of strategies to improve quality of life in shrinking cities. The thesis emphasizes that local governments should be aware of the types of culture they engage with, and the networks formed around them. Collaborations with the private sector tend to focus on economic outcomes, while partnerships with cultural NGOs and neighborhood associations promote civic empowerment and community development. Municipalities should allocate resources wisely across different cultural institutions to harness these benefits effectively.
Ellobius (Ellobius) G. Fischer 1814
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Ellobius

description: Ellobius (Ellobius) G. Fischer 1814
Ellobius (Ellobius) G. Fischer 1814, Zoognosia, Vol. 3: 72.
Type Species: Mus (Ellobius) talpinus Pallas 1770
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 974, DOI: 10.5281/zenodo.7316535
Acanthaclisis Rambur 1842
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Acanthaclisis

description: Acanthaclisis Rambur, 1842
Diagnosis. Anterior margin of the clypeo-labrum with a median cuneiform process; mandibles swollen basally, equipped with 3 teeth of which the median tooth is slightly longer than the others; ventral portion of the head capsule with sparse setae; pronotum thickly covered by stout setae; thorax with sessile setiferous processes; VIII sternite with digging setae; IX sternite with digging setae.
Examined species. A. occitanica (Villers, 1789).
Comments. Acanthaclisis is a Palaearctic genus including 7 species. The larvae have been exclusively described for A. occitanica and A. pallida (McLachlan, 1887) (Brauer 1855b; Luppova 1969; Steffan 1975; Krivokathsky 2011).
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 47, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
title: Nemesia :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Nemesia

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
Inclusion-light or innovation of inclusion: modes of innovation and exnovation for the German vocational rehabilitation and participation system
Creators: name: York, Jana
name: Jochmaring, Jan
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: vocational rehabilitation
subject: people with disabilities
subject: inclusion
subject: work
subject: innovation
subject: exnovation
subject: participation
subject: 360
subject: 370
subject: Berufliche Rehabilitation
subject: Behinderung
subject: Inklusive Pädagogik
subject: Partizipation

description: This paper examines the German system of vocational rehabilitation and participation from a system- and innovation-theoretical perspective. The German system of vocational rehabilitation and participation, with its established special systems for participation in the labor market, is facing a - long overdue - reorientation. The article presents central instruments of the vocational rehabilitation system based on legal foundations, official labor market statistics, and current research findings. The authors compare the legal requirements for an inclusive work environment with the actual employment situation of people with disabilities and highlight a central dilemma of inclusion. Two modes of innovation and exnovation in the vocational rehabilitation system are proposed and critically discussed to resolve the dilemma.
description: Frontiers in rehabilitation sciences;5