cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Designing a broad-spectrum integrative approach for cancer prevention and treatment
Creators: name: Bishayee, Anupam
name: Arbiser, Jack
name: Casey, Stephanie C.
name: Bhakta, Dipita
name: Chakrabarti, Mrinmay
name: Amedei, Amedeo
name: Chaturvedi, Rupesh
name: Ashraf, S. Salman
name: Block, Keith I.
name: Carey, Thomas E.
name: Chen, Yi Charlie
name: Benencia, Fabian
name: Arzumanyan, Alla
name: Amin, A.R.M. Ruhul
name: Blain, Stacy W.
name: Lowe, Leroy
name: Choi, Beom K.
name: Chen, Sophie
name: Arreola, Alexandra
name: Boosani, Chandra S.
name: Ciriolo, Maria Rosa
name: Aquilano, Katia
name: Carotenuto, Marianeve
name: Chen, Georgia Zhuo
name: Coley, Helen M.
name: Carnero, Amancio
name: Amin, Amr
name: Azmi, Asfar S.
name: Chen, Helen
name: Bilsland, Alan
name: Block, Penny B.
name: Gyllenhaal, Charlotte
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity “broad-spectrum” therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested; many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to help us address disease relapse, which is a substantial and longstanding problem, so a proposed agenda for future research is offered.
Search for nonresonant pair production of Higgs bosons in the $b\bar{b}b\bar{b}$ final state in $pp$ collisions at $\sqrt{s}= 13$ TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for nonresonant Higgs boson pair production in the $b\bar{b}b\bar{b}$ final state is presented. The analysis uses 126 fb$^{-1}$ of $pp$ collision data at $\sqrt{s}={13}$ TeV collected with the ATLAS detector at the Large Hadron Collider, and targets both the gluon-gluon fusion and vector-boson fusion production modes. No evidence of the signal is found and the observed (expected) upper limit on the cross-section for nonresonant Higgs boson pair production is determined to be 5.4 (8.1) times the Standard Model predicted cross-section at 95% confidence level. Constraints are placed on modifiers to the $HHH$ and $HHVV$ couplings. The observed (expected) $2σ$ constraints on the $HHH$ coupling modifier, $κ_λ$, are determined to be $[-3.5, 11.3]$ ($[-5.4, 11.4]$), while the corresponding constraints for the $HHVV$ coupling modifier, $κ_{2V}$, are $[-0.0, 2.1]$ ($[-0.1, 2.1]$). In addition, constraints on relevant coefficients are derived in the context of the Standard Model effective field theory and Higgs effective field theory, and upper limits on the $HH$ production cross-section are placed in seven Higgs effective field theory benchmark scenarios.
description: 55 pages in total, author list starting page 38, 15 figures, 10 tables, published to Phys. Rev. D: Phys. Rev. D 108 (2023) 052003. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HDBS-2019-29/
Liftable vector fields over corank one multigerms
Creators: name: Nishimura, T.
name: Sinha, R. Oset
name: Ruas, M. A. S.
name: Atique, R. Wik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 58K40 (primary), 57R45, 58K20 (secondary)

description: In this paper, a systematic method is given to construct all liftable vector fields over an analytic multigerm $f: (\mathbb{K}^n, S)\to (\mathbb{K}^p,0)$ of corank at most one admitting a one-parameter stable unfolding.
description: 34 pages. In ver. 2, several careless mistakes for calculations in Section 6 were corrected
Mahler measure of a non-reciprocal family of elliptic curves
Creators: name: Samart, Detchat
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11R06, 11F67, 33C75

description: In this article, we study the logarithmic Mahler measure of the one-parameter family \[Q_α=y^2+(x^2-αx)y+x,\] denoted by $m(Q_α)$. The zero loci of $Q_α$ generically define elliptic curves $E_α$ which are $3$-isogenous to the family of Hessian elliptic curves. We are particularly interested in the case $α\in (-1,3)$, which has not been considered in the literature due to certain subtleties. For $α$ in this interval, we establish a hypergeometric formula for the (modified) Mahler measure of $Q_α$, denoted by $\tilde{n}(α).$ This formula coincides, up to a constant factor, with the known formula for $m(Q_α)$ with $|α|$ sufficiently large. In addition, we verify numerically that if $α^3$ is an integer, then $\tilde{n}(α)$ is a rational multiple of $L'(E_α,0)$. A proof of this identity for $α=2$, which is corresponding to an elliptic curve of conductor $19$, is given.
description: Corrigendum: sign error in Theorem 1 and miscalculation in the proof of Lemma 9 fixed
Microtubule motors in eukaryotic spindle assembly and maintenance
Creators: name: Bloom, Kerry
name: Gatlin, Jesse C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The main function of the mitotic spindle is to accurately segregate replicated chromosomes during cell division. This dynamic, microtubule-based structure is assembled by a dividing cell and facilitates the orchestrated movement of chromosomes that is the hallmark of mitosis. Steady-state spindle size and morphology are relatively constant for cells of a specified type but vary considerably from one cell type to the next. Despite these differences, all eukaryotic spindles share basic architectural similarities, perhaps the most important of which is bipolar symmetry. At its core, assembling a bipolar spindle is a mechanical process that requires dynamic microtubules be moved and arranged to realize some ultimate functional form. These movements are the result of forces generated either by microtubule polymer dynamics or molecular motors. In this review we focus specifically on the motor-dependent mechanisms that shape the spindle and defer a more comprehensive treatment of spindle assembly and other motor functions during mitosis to others [1].
КРИТИКА КОНЦЕПЦИИ РОСТА КАК КАТЕГОРИИ ЭКОНОМИЧЕСКОЙ ТЕОРИИ В КОНТЕКСТЕ ИСТОРИЧЕСКОЙ РЕТРОСПЕКТИВЫ
Creators: name: Пилюшкин Н.С.
Publisher: name: Образование и право
Year: 2022
Subjects: история
рост
финансы
экономика
экономисты.

description: В статье приводится критика роста как категории экономической теории. Рассматривается история становления экономической теории в общем и концепции экономического роста, в частности. Приводятся критические суждения в пользу несостоятельности объективности категории роста в экономической науке на основе опыта становления экономической реальности.
Additional file 3 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study
Creators: name: Yip, Olivia
name: Dhaini, Suzanne
name: Esser, Jan
name: Siqeca, Flaka
name: Mendieta, Maria Jose
name: Huber, Evelyn
name: Zeller, Andreas
name: De Geest, Sabina
name: Deschodt, Mieke
name: Zúñiga, Franziska
name: Zullig, Leah L.
name: King, Heather A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 3. Example Questions from the Interview Guide used in the INSPIRE parent study (translated from German) (Esser et al., 2022).
YEVROPA LINGVISTIKA AN'ANALARI TARIXI
Creators: name: Mirzabayeva Saida Alisherovna Oriental Universiteti Lingvistika Arab tili 2 kurs talabasi
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada Yevropa  tilshunoslik anʼanalarining kelib chiqishi va rivojlanishi tasvirlangan.

Kalit so'zlar: tilshunoslik tarixi, qadimgi an'ana, lingvistik usullar
Differentiating surface and bulk interactions in nanoplasmonic interferometric sensor arrays
Creators: name: Zeng, Beibei
name: Gao, Yongkang
name: Bartoli, Filbert J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Detecting specific target analytes and differentiating them from interfering background effects is a crucial but challenging task in complex multi-component solutions commonly encountered in environmental, chemical, biological, and medical sensing applications. Here we present a simple nanoplasmonic interferometric sensor platform that can differentiate the adsorption of a thin protein layer on the sensor surface (surface effects) from bulk refractive index changes (interfering background effects) at a single sensing spot, exploiting the different penetration depths of multiple propagating surface plasmon polaritons excited in the ring-hole nanostructures. A monolayer of bovine serum albumin (BSA) molecules with an effective thickness of 1.91nm is detected and differentiated from a 10-3 change in the bulk refractive index unit of the solution. The noise level of the retrieved real-time sensor output compares favorably with traditional prism-based surface plasmon resonance sensors, but is achieved using a significantly simpler collinear transmission geometry and a miniaturized sensor footprint.
Nrg1/ErbB signaling networks in Schwann cell development and myelination
Creators: name: Birchmeier, Carmen
name: Newbern, Jason
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation, migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of genetic models has unmasked fundamental mechanisms underlying the specificity of the Nrg1/ErbB signaling axis. Differential expression of Nrg1 isoforms, Nrg1 processing, and ErbB receptor localization and trafficking represent important regulatory themes in the control of Nrg1/ErbB function. Nrg1 binding to ErbB2/3 receptors results in the activation of intracellular signal transduction pathways that initiate changes in Schwann cell behavior. Here, we review data that has defined the role of key Nrg1/ErbB signaling components like Shp2, ERK1/2, FAK, Rac1/Cdc42 and calcineurin in development of the Schwann cell lineage in vivo. Many of these regulators receive converging signals from other cues that are provided by Notch, integrin or G-protein coupled receptors. Signaling by multiple extracellular factors may act as key modifiers and allow Schwann cells at different developmental stages to respond in distinct manners to the Nrg1/ErbB signal.
title: Including Bombus impatiens in the mix: Developing semi-field pesticide risk assessment methodology for the North American surrogate bumble bee
Creators: name: Scott-Dupree, Cynthia
name: Gradish, Angela E.
name: Coletti, Tara
name: Cutler, Chris
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Julius-Kühn-Archiv, Nr. 462 (2018): Hazards of pesticides to bees 13th International Symposium of the ICP-PR Bee Protection Group 18. - 20. October 2017, València (Spain) - Proceedings -
MooseNet: A Trainable Metric for Synthesized Speech with a PLDA Module
Creators: name: Plátek, Ondřej
name: Dušek, Ondřej
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Sound (cs.SD)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We present MooseNet, a trainable speech metric that predicts the listeners' Mean Opinion Score (MOS). We propose a novel approach where the Probabilistic Linear Discriminative Analysis (PLDA) generative model is used on top of an embedding obtained from a self-supervised learning (SSL) neural network (NN) model. We show that PLDA works well with a non-finetuned SSL model when trained only on 136 utterances (ca. one minute training time) and that PLDA consistently improves various neural MOS prediction models, even state-of-the-art models with task-specific fine-tuning. Our ablation study shows PLDA training superiority over SSL model fine-tuning in a low-resource scenario. We also improve SSL model fine-tuning using a convenient optimizer choice and additional contrastive and multi-task training objectives. The fine-tuned MooseNet NN with the PLDA module achieves the best results, surpassing the SSL baseline on the VoiceMOS Challenge data.
description: Accepted to SSW 12: https://openreview.net/forum?id=V6RZk6RzSu
Amyloid in neurodegenerative diseases: Friend or foe?
Creators: name: Cyr, Douglas M.
name: Wolfe, Katie J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Accumulation of amyloid-like aggregates is a hallmark of numerous neurodegenerative disorders such as Alzheimer’s and polyglutamine disease. Yet, whether the amyloid inclusions found in these diseases are toxic or cytoprotective remains unclear. Various studies suggest that the toxic culprit in the amyloid folding pathway is actually a soluble oligomeric species which might interfere with normal cellular function by a multifactorial mechanism including aberrant protein-protein interactions. Molecular chaperones suppress toxicity of amyloidogenic proteins by inhibiting aggregation of non-native disease substrates and targeting them for refolding or degradation. Paradoxically, recent studies also suggest a protective action of chaperones in their promotion of the assembly of large, tightly packed, benign aggregates that sequester toxic protein species.
Explicit bounds for the high-frequency time-harmonic Maxwell equations in heterogeneous media
Creators: name: Chaumont-Frelet, Théophile
name: Moiola, Andrea
name: Spence, Euan A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We consider the time-harmonic Maxwell equations posed in $\mathbb{R}^3$. We prove a priori bounds on the solution for $L^\infty$ coefficients $ε$ and $μ$ satisfying certain monotonicity properties, with these bounds valid for arbitrarily-large frequency, and explicit in the frequency and properties of $ε$ and $μ$. The class of coefficients covered includes (i) certain $ε$ and $μ$ for which well-posedness of the time-harmonic Maxwell equations had not previously been proved, and (ii) scattering by a penetrable $C^0$ star-shaped obstacle where $ε$ and $μ$ are smaller inside the obstacle than outside. In this latter setting, the bounds are uniform across all such obstacles, and the first sharp frequency-explicit bounds for this problem at high-frequency.
Additional file 1 of Early identification of bleeding in trauma patients: external validation of traumatic bleeding scores in the Swiss Trauma Registry
Creators: name: Costa, Alan
name: Carron, Pierre-Nicolas
name: Zingg, Tobias
name: Roberts, Ian
name: Ageron, François-Xavier
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. 1. Summary of development and validation method of each trauma bleeding score.2. Definition of statistics and performance indicators.3. Receiving Operating Curve (ROC) of bleeding scores for very early death within 12 h.4. Calibration Curves for external validation of BATT and TASH score.
НАРУШЕНИЕ УСЛОВИЙ ИСПОЛНЕНИЯ ДОГОВОРА О СУРРОГАТНОМ МАТЕРИНСТВЕ
Creators: name: Алеева С.С.
Publisher: name: Образование и право
Year: 2022
Subjects: суррогатное материнство
договор суррогатного материнства
биологические родители.

description: Договор суррогатного материнства является взаимным и порождает для сторон взаимные права и обязанности. Поскольку в российском законодательстве отсутствует легальное определение и правовое регулирование договора суррогатного материнства, то в вопросе о правах и обязанностях сторон необходимо исходить из основных начал гражданского и семейного законодательства.
Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates
Creators: name: Jin, Suk-Won
name: Wiley, David M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Bone Morphogenetic Protein (BMP) signaling has been implicated in diverse biological processes. Although how BMP signaling regulates behaviors of endothelial cells during angiogenesis are not fully understood, increasing evidence indicate functions of BMP signaling components are essential in developmental and pathological angiogenesis. Here we review recent advances in delineating the functions of BMP signaling during angiogenesis. In addition, we discuss downstream pathways that transduce BMP signaling in endothelial cells, and factors that modulate BMP signaling response in endothelial cells. Finally, we provide recent insight on how BMP signaling functions as a context dependent angiogenic cue.
Time-Conditioned Generative Modeling of Object-Centric Representations for Video Decomposition and Prediction
Creators: name: Gao, Chengmin
name: Li, Bin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: When perceiving the world from multiple viewpoints, humans have the ability to reason about the complete objects in a compositional manner even when an object is completely occluded from certain viewpoints. Meanwhile, humans are able to imagine novel views after observing multiple viewpoints. Recent remarkable advances in multi-view object-centric learning still leaves some unresolved problems: 1) The shapes of partially or completely occluded objects can not be well reconstructed. 2) The novel viewpoint prediction depends on expensive viewpoint annotations rather than implicit rules in view representations. In this paper, we introduce a time-conditioned generative model for videos. To reconstruct the complete shape of an object accurately, we enhance the disentanglement between the latent representations of objects and views, where the latent representations of time-conditioned views are jointly inferred with a Transformer and then are input to a sequential extension of Slot Attention to learn object-centric representations. In addition, Gaussian processes are employed as priors of view latent variables for video generation and novel-view prediction without viewpoint annotations. Experiments on multiple datasets demonstrate that the proposed model can make object-centric video decomposition, reconstruct the complete shapes of occluded objects, and make novel-view predictions.
How signaling between cells can orient a mitotic spindle
Creators: name: Goldstein, Bob
name: Werts, Adam D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: In multicellular animals, cell communication sometimes serves to orient the direction in which cells divide. Control of division orientation has been proposed to be critical for partitioning developmental determinants and for maintaining epithelial architecture. Surprisingly, there are few cases where we understand the mechanisms by which external cues, transmitted by intercellular signaling, specify the division orientation of animal cells. One would predict that cytosolic molecules or complexes exist that are capable of interpreting extrinsic cues, translating the positions of these cues into forces on microtubules of the mitotic spindle. In recent years, a key intracellular complex has been identified that is required for pulling forces on mitotic spindles in Drosophila, C. elegans and vertebrate systems. One member of this complex, a protein with tetratricopeptide repeat (TPR) and GoLoco (Gα-binding) domains, has been found localized in positions that coincide with the positions of spindle-orienting extracellular cues. Do TPR-GoLoco proteins function as conserved, spatially-regulated mediators of spindle orientation by intercellular signaling? Here, we review the relevant evidence among cases from diverse animal systems where this protein complex has been found to localize to specific cell-cell contacts and to be involved in orienting mitotic spindles.
Regulation of blood vessel sprouting
Creators: name: Wiley, David M.
name: Bautch, Victoria L.
name: Chappell, John C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Blood vessels are essential conduits of nutrients and oxygen throughout the body. The formation of these vessels involves angiogenic sprouting, a complex process entailing highly integrated cell behaviors and signaling pathways. In this review, we discuss how endothelial cells initiate a vessel sprout through interactions with their environment and with one another, particularly through lateral inhibition. We review the composition of the local environment, which contains an initial set of guidance cues to facilitate the proper outward migration of the sprout as it emerges from a parent vessel. The long-range guidance and sprout stability cues provided by soluble molecules, extracellular matrix components, and interactions with other cell types are also discussed. We also examine emerging evidence for mechanisms that govern sprout fusion with its target and lumen formation.
title: Combined CT-guided percutaneous byopsia, microwave ablation and cementoplasty: our experience in the treatment of painful bone metastases.
Creators: name: Costanzo, Vincenzo
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Bones
subject: Interventional non-vascular
subject: Musculoskeletal system
subject: CT
subject: Ablation procedures
subject: Biopsy
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Cancer commonly metastasizes to bone and up to 80% of breast, prostate, and lung cancer patients will have bone metastases. The site and distribution of bone metastases, and the presence of skeletal complications such as pathologic fracture and...
НЕКОТОРЫЕ ИТОГИ ПРИМЕНЕНИЯ ПРОПОРЦИОНАЛЬНОЙ ИЗБИРАТЕЛЬНОЙ СИСТЕМЫ В РОССИЙСКОЙ ФЕДЕРАЦИИ (ИСТОРИЧЕСКИЙ АСПЕКТ)
Creators: name: Котельникова Т.А.
name: Пошивайлова А.В.
Publisher: name: Образование и право
Year: 2022
Subjects: избирательное право
избирательная система
выборы
пропорциональная избирательная система
политические партии
партийный список
порог явки
«против всех».

description: Проблема выбора оптимальной избирательной системы является довольно актуальной для Российской Федерации. Свободные выборы на основе всеобщего равного и прямого избирательного права при тайном голосовании, согласно статье 3 (части 3) Конституции Российской Федерации, наряду с референдумом являются высшим и непосредственным выражением власти народа. Свобода выборов предполагает, прежде всего, беспрепятственное осуществление избирательных прав их обладателями. Современное избирательное законодательство в целом отражает опыт избирательных кампаний в Российской Федерации и во многом гарантирует возможность адекватной защиты и восстановления широкого круга избирательных прав. Вместе с тем, в ходе избирательных кампаний все еще возникают спорные ситуации, связанные с различного рода ограничениями избирательных возможностей граждан и иных участников избирательного процесса.
Additional file 1 of Status of the latest 2016 World Health Organization recommended frequency of antenatal care contacts in Sierra Leone: a nationally representative survey
Creators: name: Sserwanja, Quraish
name: Musaba, Milton W.
name: Kamara, Kassim
name: Mutisya, Linet M.
name: Mukunya, David
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cardiology

description: Additional file 1.
НЕКОТОРЫЕ ПРАВОВЫЕ ПРОБЛЕМЫ РЕАЛИЗАЦИИ ОХРАНЫ ВОДНЫХ РЕСУРСОВ КАСПИЙСКОГО МОРЯ В ДАГЕСТАНЕ
Creators: name: Дибраев А.Д.
name: Гаджибекова З.М.
name: Курбанова М.Н.
Publisher: name: Образование и право
Year: 2022
Subjects: экология
экологические проблемы
загрязнение
водные ресурсы
защита и охрана
здоровье.

description: Данная статья рассматривает конституционные положения, гарантии экологических прав граждан, а также проблемы их реализации, основные причины, источники и последствия, к которым приводит нерациональное использование водных ресурсов. Около 70% поверхности Земли занимает вода, и, несомненно, она является бесценным ресурсом для человечества. Используя воду в самых разных целях, начиная с бытовой деятельности и заканчивая промышленной, мы пришли к тому, что на сегодняшний день в мире большая часть водных источников непригодны для потребления и пользования. Эта проблема очень актуальна в Дагестане, многие бассейны рек находятся в неблагополучной экологической ситуации, от чего страдает флора и фауна, возникают массовые отравления населения. Актуальность темы: вместе с улучшением качества человеческой жизни всё сильнее проявляется экологический дисбаланс, а из-за ускоренного развития антропогенной деятельности природа не успевает восстанавливаться самостоятельно. Органы управления, реализующие защиту и охрану окружающей среды, в свою очередь, не выполняют обязанности должным образом, а граждане не занимаются отстаиванием своих экологических прав. Поэтому сегодня мы сталкиваемся с множеством экологических проблем, одной из важнейших среди них является загрязнение и истощение водных ресурсов. От наших действий зависит качество жизни на Земле в будущем, в этом проявляется актуальность темы на сегодняшний день. Методы исследования: аналитический метод на основе учебных и фондовых изданий, анализ изменений в политике в сфере экологической безопасности.
On how nanomechanical systems can minimize dissipation
Creators: name: Muratore-Ginanneschi, Paolo
name: Schwieger, Kay
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Information processing machines at the nanoscales are unavoidably affected by thermal fluctuations. Efficient design requires understanding how nanomachines can operate at minimal energy dissipation. In this letter we focus on mechanical systems controlled by smoothly varying potential forces. We show that optimal control equations come about in a natural way if the energy cost to manipulate the potential is taken into account. When such cost becomes negligible, the optimal control strategy can be constructed by transparent geometrical methods and recovers the solution of optimal mass transport equations in the overdamped limit. Our equations are equivalent to hierarchies of kinetic equations of a form well-known in the theory of dilute gases. From our results, optimal strategies for energy efficient nanosystems may be devised
description: Minor revision, 5 pages, 2 figures. Supplemental material downloadable from the web-pages of the authors
Alterations of metabolic genes and metabolites in cancer
Creators: name: Xiong, Yue
name: Oermann, Eric K.
name: Wu, Jing
name: Guan, Kun-Liang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings—the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer—have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.
Marginal Stability in Structural, Spin and Electron Glasses
Creators: name: Müller, Markus
name: Wyart, Matthieu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We revisit the concept of marginal stability in glasses, and determine its range of applicability in the context of avalanche-type response to slow external driving. We argue that there is an intimate connection between a pseudo-gap in the distribution of local fields and crackling in systems with long-range interactions. We show how the principle of marginal stability offers a unifying perspective on the phenomenology of systems as diverse as spin and electron glasses, hard spheres, pinned elastic interfaces and the plasticity of soft amorphous solids.
description: review
Computational analysis of signaling patterns in single cells
Creators: name: Davis, Denise M.
name: Purvis, Jeremy E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Signaling proteins are flexible in both form and function. They can bind to multiple molecular partners and integrate diverse types of cellular information. When imaged by time-lapse microscopy, many signaling proteins show complex patterns of activity or localization that vary from cell to cell. This heterogeneity is so prevalent that it has spurred the development of new computational strategies to analyze single-cell signaling patterns. A collective observation from these analyses is that cells appear less heterogeneous when their responses are normalized to, or synchronized with, other single-cell measurements. In many cases, these transformed signaling patterns show distinct dynamical trends that correspond with predictable phenotypic outcomes. When signaling mechanisms are unclear, computational models can suggest putative molecular interactions that are experimentally testable. Thus, computational analysis of single-cell signaling has not only provided new ways to quantify the responses of individual cells, but has helped resolve longstanding questions surrounding many well-studied human signaling proteins including NF-κB, p53, ERK1/2, and CDK2. A number of specific challenges lie ahead for single-cell analysis such as quantifying the contribution of non-cell autonomous signaling as well as the characterization of protein signaling dynamics in vivo.
Additional file 4 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study
Creators: name: Yip, Olivia
name: Dhaini, Suzanne
name: Esser, Jan
name: Siqeca, Flaka
name: Mendieta, Maria Jose
name: Huber, Evelyn
name: Zeller, Andreas
name: De Geest, Sabina
name: Deschodt, Mieke
name: Zúñiga, Franziska
name: Zullig, Leah L.
name: King, Heather A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 4. Joint display table integrating study findings from the INSPIRE population survey and interviews.
НОРМАТИВНО – ПРАВОВАЯ БАЗА РАЗВИТИЯ ЭКСПОРТА СПГ В РОССИИ
Creators: name: Емельянов В.В.
Publisher: name: Образование и право
Year: 2022
Subjects: сжиженный природный газ
экспорт СПГ
нормативно-правовая база
государственное регулирование
экспорт газа.

description: Создание нормативно-правовой базы экспорта СПГ является необходимым этапом для развития экспорта газа с целью удовлетворения интересов страны. Федеральный закон N 117 стал отправной точкой и основой для государственного регулирования газового экспорта. Все больше компаний («Роснефть», «НОВАТЭК») получают право на экспорт сжиженного природного газа благодаря внесенным изменениям в Федеральный закон «Об экспорте газа». Благодаря дальнейшему развитию нормативной базы также открылась возможность разработки новых месторождений (Верхнетиутейское, Штормовое и др.) и реализации новых проектов («Арктик СПГ 2», «Обский СПГ» и др.).
A Gestão De Acervos Como Ação De Conservação: Atuação Do Conservador-Restaurador Na Reserva Técnica Do Cap
Creators: name: Elvira Nóbrega de Faria Tobias
name: Yukie Noce Watanabe
name: Larissa Lorrane Silva Oliveira
Publisher: name: Zenodo
Year: 2024

description: O presente resumo pretende registrar os trabalhos desenvolvidos pelos profissionais do Núcleo de Gestão de Acervos Museológicos (NGAM) da Diretoria de Museus (DIMUS), gerido pela Secretaria de Estado de Cultura e Turismo de Minas Gerais, no Brasil, e que teve como objetivo a conservação do acervo do CAP - Centro de Arte Popular, espaço cultural que faz parte do Circuito Liberdade, circuito turístico da cidade, sendo um espaço destinado à exposição e valorização de obras produzidas pela cultura popular. Inicialmente foram feitos apontamentos de conceito e objetivos de uma Reserva Técnica - RT, espaço relevante a ser planejado na instituição  de um museu, pois nela é armazenado e conservado o acervo que não se encontra exposto ao público, mas que é pesquisado, disponibilizado em exposições temporárias e empréstimos.  A seguir é apresentada a diversidade de objetos e tipos de material do acervo do CAP, constituído de madeira, cerâmica, fibras naturais, pedras, e metal, com peças originárias de diversas cidades e regiões de Minas Gerais. Para aprofundar no trabalho realizado foi feito um estudo da criação da RT identificando que seu projeto inicial foi executado em local inadequado, apontando os motivos que motivaram o NGAM a transferi-la de local, seguindo diretrizes de conservação, estruturando e organizando o espaço. As ações foram efetuadas com equipe local, com infraestrutura e material disponível e se mostraram bem sucedidas, resultando na organização e catalogação sistemática do acervo, possibilitando a sua manutenção rotineira e garantindo assim a valorização e gestão segura do acervo visando a preservação desse segmento do patrimônio cultural mineiro.
Latino until proven innocent: navigating crimmigration in U.S. immigration courts
Creators: name: Avila Jaimes, Lorena Paola
Publisher: name: No Publisher Supplied
Year: 2024

description: I explore how law and legal bureaucracies create and reproduce ethnic and racial inequalities via immigration court. First, I examine whether criminal records and the availability of legal representation for immigrants from Latin America and the Caribbean reduce the average probability of being released on bond. Second, I qualitatively assess legal cultures and practices in immigration court through the lived experiences of people undergoing proceedings, the organizational culture of the courts, and immigrant communities’ challenges and innovative defense strategies in these legal spaces.I pose three interrelated questions. Are there unequal patterns in bond decisions? How do people with criminal records experience precarious legal protections in immigration court? Finally, how do attorneys confront the mark of the criminal record? Three sets of interrelated data are used through mixed methods strategies. First, I draw from the Executive Office for Immigration Review-EOIR Bond Case Data (1991-2020). Second, I draw from over 100 hours of remote (via Webex) and in-person ethnographic observation of four federal Immigration courts. Finally, semi-structured interviews approach immigrants and intermediaries, sharing strategies for navigating the crimmigration nexus. I provide substantiation of biased decision-making, problematizing judicial discretion in a context where civil detention is unfairly applied. Latin America and Caribbean nationals are more likely to be denied bond, being disproportionately held in civil detention, regardless of whether they have a criminal history. This inequality is worsened in cases without legal representation. The mutability, adaptation, and extension of criminal records in immigration law display a space of inequality and racialization shaped by the bureaucratic structures in place. Qualitative data shows how judges exchange information with respondents from the initial stages of proceedings. In the absence of attorneys in those early stages, the construction of a racial migrant subject is concomitant to multiple repertoires of legal violence experienced by respondents. Attorneys in non-profit organizations acknowledge the challenges that the immigration system poses and how the overexposure of these communities to the criminal system knits together a political project of surveillance, stigmatization, detention, and likely deportation. Thus, their consciousness of the law is a motivation to confront it.
Animal Models of Hemophilia and Related Bleeding Disorders
Creators: name: Nichols, Timothy C.
name: Lozier, Jay N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Animal models of hemophilia and related diseases are important for development of novel treatments and to understand the pathophysiology of bleeding disorders in humans. Testing in animals with the equivalent human disorder provides informed estimates of doses and measures of efficacy, which aids in design of human trials. Many models of hemophilia A, hemophilia B, and von Willebrand disease have been developed from animals with spontaneous mutations (hemophilia A dogs, rats, sheep; hemophilia B dogs; and von Willebrand disease pigs and dogs), or by targeted gene disruption in mice to create hemophilia A, B, or VWD models. Animal models have been used to generate new insights into the pathophysiology of each bleeding disorder and also to perform pre-clinical assessments of standard protein replacement therapies as well as novel gene transfer technology. Both the differences between species and differences in underlying causative mutations must be considered in choosing the best animal for a specific scientific study
Additional file 5 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study
Creators: name: Yip, Olivia
name: Dhaini, Suzanne
name: Esser, Jan
name: Siqeca, Flaka
name: Mendieta, Maria Jose
name: Huber, Evelyn
name: Zeller, Andreas
name: De Geest, Sabina
name: Deschodt, Mieke
name: Zúñiga, Franziska
name: Zullig, Leah L.
name: King, Heather A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 5. Concepts related to care and support of frail older adults in 2018 and preferences for future, mapped to adapted domains of the SELFIE framework, including only respondents who indicated no current use for each question respectively, but responded for future preferences.
Coloring lines and Delaunay graphs with respect to boxes
Creators: name: Tomon, István
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The goal of this paper is to show the existence (using probabilistic tools) of configurations of lines, boxes, and points with certain interesting combinatorial properties. (i) First, we construct a family of $n$ lines in $\mathbb{R}^3$ whose intersection graph is triangle-free of chromatic number $Ω(n^{1/15})$. This improves the previously best known bound $Ω(\log\log n)$ by Norin, and is also the first construction of a triangle-free intersection graph of simple geometric objects with polynomial chromatic number. (ii) Second, we construct a set of $n$ points in $\mathbb{R}^d$, whose Delaunay graph with respect to axis-parallel boxes has independence number at most $n\cdot (\log n)^{-(d-1)/2+o(1)}$. This extends the planar case considered by Chen, Pach, Szegedy, and Tardos.
description: 18 pages; one of the results was already known in the previous version, so updated accordingly; published in Random Structures & Algorithms
ОБУЧЕНИЕ СТУДЕНТОВ ПРОФЕССИОНАЛЬНО-НАПРАВЛЕННОМУ АНГЛОЯЗЫЧНОМУ ДИСКУРСУ В ОБЛАСТИ СУДЕБНОЙ ЭКСПЕРТИЗЫ ЦИФРОВОЙ ИНФОРМАЦИИ В МЕЖДИСЦИПЛИНАРНОМ КОНТЕКСТЕ
Creators: name: Емельянова Т.В.
Publisher: name: Образование и право
Year: 2022
Subjects: междисциплинарный контекст
международный
метод проектов
профессионально-направленный англоязычный дискурс
судебная экспертиза цифровой информации.

description: В статье рассматривается междисциплинарный контекст обучения студентов неязыкового вуза профессионально-направленному англоязычному дискурсу в области судебной экспертизы цифровой информации. Обозначена практическая ценность применения метода проектов с целью формирования необходимых компетенций. Затрагивается важность адекватного применения англоязычной терминологии, коллокаций и многосложных труднопроизносимых словосочетаний. Актуальность описанной практики обучения обусловлена интенсивными кардинальными изменениями российской и международной правовой системы вследствие инновационных прорывов с применением искусственного интеллекта и цифровизации. Представлены некоторые критерии оценивания результативности процесса обучения. Автором делается вывод о том, что развитые профессионально-направленные англоязычные дискурсивные умения позволят судебным экспертам эффективно осуществлять свою деятельность в любых ситуациях, обусловленных локальными и международными событиями.
Additional file 1 of Assessing the psychometric performance of EQ-5D-5L in dementia: a systematic review
Creators: name: Keetharuth, Anju D.
name: Hussain, Hannah
name: Rowen, Donna
name: Wailoo, Allan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Table S1: Known-group validity (7 studies). Table S2: Convergent validity (9 studies). Table S3: Reliability (7 studies). Table S4 Quality assessment of included papers adapted from the GRADE assessment tool.
A gestão de acervos como ação de Conservação: atuação do Conservador-Restaurador na reserva técnica do CAP
Creators: name: Nóbrega de Faria Tobias, Elvira
name: Noce Watanabe, Yukie
name: Lorrane Silva Oliveira, Larissa
Publisher: name: Zenodo
Year: 2024

description: O presente resumo pretende registrar os trabalhos desenvolvidos pelos profissionais do Núcleo de Gestão de Acervos Museológicos (NGAM) da Diretoria de Museus (DIMUS), gerido pela Secretaria de Estado de Cultura e Turismo de Minas Gerais, no Brasil, e que teve como objetivo a conservação do acervo do CAP - Centro de Arte Popular, espaço cultural que faz parte do Circuito Liberdade, circuito turístico da cidade, sendo um espaço destinado à exposição e valorização de obras produzidas pela cultura popular. Inicialmente foram feitos apontamentos de conceito e objetivos de uma Reserva Técnica - RT, espaço relevante a ser planejado na instituição  de um museu, pois nela é armazenado e conservado o acervo que não se encontra exposto ao público, mas que é pesquisado, disponibilizado em exposições temporárias e empréstimos.  A seguir é apresentada a diversidade de objetos e tipos de material do acervo do CAP, constituído de madeira, cerâmica, fibras naturais, pedras, e metal, com peças originárias de diversas cidades e regiões de Minas Gerais. Para aprofundar no trabalho realizado foi feito um estudo da criação da RT identificando que seu projeto inicial foi executado em local inadequado, apontando os motivos que motivaram o NGAM a transferi-la de local, seguindo diretrizes de conservação, estruturando e organizando o espaço. As ações foram efetuadas com equipe local, com infraestrutura e material disponível e se mostraram bem sucedidas, resultando na organização e catalogação sistemática do acervo, possibilitando a sua manutenção rotineira e garantindo assim a valorização e gestão segura do acervo visando a preservação desse segmento do patrimônio cultural mineiro.
The future of food allergy therapeutics
Creators: name: Henson, Michele
name: Burks, A. Wesley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and growth delay as well as psychosocial burdens and the potential for fatal anaphylaxis. There is currently no effective form of therapy, and the mainstay of treatment remains strict avoidance. However, there are a number of promising therapeutic strategies currently being investigated for the treatment of food allergies. Allergen-specific approaches, such as various forms of immunotherapy, have been a major focus of investigation and appear to be promising methods of desensitization. More recently, the addition of anti-IgE monoclonal antibodies (mAbs) to immunotherapy regimens has been studied. Early work with antigen-fixed leukocytes in a murine model has shown promise in inducing tolerance, as have vaccines containing modified recombinant food proteins coadministered with heat-killed Escherichia coli. Nonspecific approaches include a Chinese herbal formulation, anti-IgE mAbs, and Trichuris suis ova therapy. The array of treatment modalities currently being investigated increases the likelihood of finding one or more effective therapies for the treatment of food allergy.