cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IL DIRITTO IN MOVIMENTO. HANS KELSEN E L'EVOLUZIONE MACROSTORICA DEGLI ORDINAMENTI GIURIDICI
Creators: name: SAMMARCO, STEFANO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: La presente tesi di ricerca dottorale -dal titolo "Il diritto in Movimento. Hans Kelsen e l'evoluzione macrostorica degli ordinamenti giuridici"- � dedicata alla complessa e articolata questione del carattere evolutivo del fenomeno giuridico. Essa si compone di tre capitoli. Il primo capitolo, dal titolo "I due volti dell?evoluzione giuridica", � dedicato alla proposta ed elaborazione di una tesi metateorica di fondo, relativa alla possibilit� e necessit� di distinguere tra "teorie dell?evoluzione nel diritto" e "teorie evolutive del diritto" come linee di ricerca che in modi essenzialmente differenti trattano dell?evoluzione giuridica. Nel primo capitolo, si procede, dunque, con una breve ricostruzione storico-critica della genesi, degli sviluppi e della fortuna delle teorie dell?evoluzione nel diritto, con un?analisi delle ragioni che hanno condotto a misconoscere il valore delle teorie evolutive del diritto e con un tentativo di rivalutare la rilevanza teoretica e pratico-politica delle stesse. Il secondo capitolo, dal titolo "Evoluzione macrostorica del diritto: la vasta storia di un?idea", � invece dedicato alla storia delle teorie evolutive del diritto. Obiettivo di tale sezione storiografica della presente ricerca � mettere in evidenza come i tentativi di elaborare ricostruzioni dell?evoluzione macrostorica del diritto non possano essere circoscritti al XIX secolo come da vulgata, essendo quella delle teorie evolutive del diritto una linea di ricerca che pu� vantare una lunga tradizione che, risalente fino all?antichit� classica, viene portata avanti ancora oggi da alcuni studiosi. Il terzo capitolo della presente ricerca � dedicato invece all?esame dettagliato delle riflessioni concernenti l?evoluzione macrostorica degli ordinamenti giuridici che Hans Kelsen ha proposto in alcune opere degli anni Quaranta del XX secolo. La scelta di procedere con tale approfondimento deriva, in primo luogo, dalla constatazione che non � mai stata tentata una ricostruzione unitaria di tale versante della riflessione giusfilosofica di Kelsen. In secondo luogo, ancora dal punto di vista storiografico, l?analisi della teoria kelseniana dell?evoluzione macrostorica degli ordinamenti giuridici si rivela certamente interessante per una rivalutazione di alcuni assunti o pregiudizi relativi all?ontologia giuridica e all?epistemologia giuridica di Kelsen. Infine, la scelta di procedere con tale approfondimento deriva dalla convinzione che la teoria di Kelsen sull?evoluzione macrostorica degli ordinamenti giuridici risulti essere ricca di intuizioni che ancora oggi si rivelano di estremo valore.
Serological survey of Leishmania infantum and Trypanosoma cruzi in dogs from urban areas of Brazil and Colombia
Creators: name: Lindsay, D.S.
name: Tidwell, R.R.
name: Gennari, S.M.
name: Rosypal, A.C.
name: Cortés-Vecino, J.A.
name: Dubey, J.P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Leishmania infantum and Trypanosoma cruzi are zoonotic parasites that are endemic throughout many parts of Latin America. Infected dogs play an important role in transmission of both parasites to humans. A serological survey of Leishmania and Trypanosoma infection was conducted on 365 dogs from São Paulo, Brazil and Bogatá, Colombia, South America. Serum samples were examined by the indirect immunofluorescent antibody test (IFAT). Anti-Leishmania IgG antibodies were detected in 5 of 107 from Brazil (4.7 %) and in 4 of 258 dogs (1.6%) from Colombia. Titers ranged from 1:25 to 1:100. Anti-T. cruzi antibodies were not detected in any of the dogs from either Brazil or Colombia. The results show a low prevalence of anti-Leishmania antibodies and no antibodies against T. cruzi in these canine populations. Our study suggests that dogs play a limited role in the spread of L. infantum and T. cruzi in these urban areas of Brazil and Colombia.
title: Un confronto sulla neuroetica. Il dibattito fra Habermas e Searle
Creators: name: Giovagnoli , Raffaela
Publisher: name: Roma Tre-Press
Year: 2010

description: Il tema trattato dal presente contributo riguarda la possibilità concreta del libero arbitrio, che secondo Habermas e Searle non può essere risolta facendo riferimento alla discussione metafisica tradizionale, se si considerano i rilevanti progressi compiuti negli studi sulla cognizione umana. In questo senso, sia Habermas sia Searle non si differenziano da molte teorie contemporanee che tentano di definire una nozione di autonomia personale distaccandosi dalla discussione classica della metafisica sul libero arbitrio.

description: B@belonline vol. 8 Musica e Bildung. Saper suonare e imparare ad ascoltare
Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma
Creators: name: Phang, T. L.
name: Scott, M. C.
name: Borgatti, A.
name: Husbands, B. D.
name: O’Brien, T. D.
name: Breen, M.
name: Sarver, A. L.
name: Lindblad-Toh, K.
name: Ito, D.
name: Henson, M. S.
name: Kisseberth, W. C.
name: Frantz, A. M.
name: Karimpour-Fard, A.
name: Modiano, J. F.
name: Burgess, K. E.
name: Valli, V. E. O.
name: Hunter, L. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma, consisting of marginal B-cell lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Interspecies comparative analyses of gene expression profiles also showed that marginal B-cell lymphoma and diffuse large B-cell lymphoma in dogs and humans might represent a continuum of disease with similar drivers. The classification of these diverse tumors into 3 subgroups was prognostically significant, as the groups were directly correlated with event-free survival. Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results.
RV POSEIDON 523 Cruise Report / Fahrtbericht Malaga (Spain) 02.05.2018 Ponta Delgada (Azores) 23.05.2018 POS523 - ENERGY TRANSFER II
Creators: name: Walter, Maren
name: Köhler, Janna
name: Löb, Jonas
name: Loureiro, Clara
name: Stiehler, Jan
name: Gemmrich, Helen
name: Fandrich, Jennifer
name: Adam, Lia
name: Liu, Yuqing
name: Reitz, Thomas
Publisher: name: GEOMAR
Year: 2019

description: The RV Poseidon cruise 523 (POS523) is the second cruise to the work area as part of the observational program of the TRR 181 'Energy Transfers in Atmosphere and Ocean', and focussed on the energy transfer by low-mode internal waves. The goals of the cruise were to recover and redeploy a mooring to record the temporal variability of the internal wave field and associated energy fluxes, and to use time series CTD/LADCP/microstructure stations to assess locally the temporal variability of mixing, dissipation, and internal wave fluxes. The region south of the Azores in the east Atlantic is ideally suited for this kind of process study, because it is an area of a strong internal tide signal radiating away from the islands. The cruise track is located south of a chain of seamounts in a tidal beam formed by constructive interference of internal tides, and crosses the critical latitude for parametric subharmonic instability (PSI). During the cruise, we collected time series of CTD/LADCP and microstructure between 36 h and 52 h length on 5 stations in up to 4600 m water depth along the tidal beam between 29°20°N and 32°N latitude. In total 64 CTD/LADCP casts and 18 microstructure data sets were measured. The mooring equipped with current meter/temperature logger pairs and acoustic Doppler current profiler was successfully recovered and later redeployed along the track at 30°29°N, 30°12°W in a water depth of 4500 m (to be retrieved in 2019). All anticipated goals of the cruise were accomplished.
Semi-classical analysis of non self-adjoint transfer matrices in statistical mechanics. I
Creators: name: Disertori, Margherita
name: Sodin, Sasha
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We propose a way to study one-dimensional statistical mechanics models with complex-valued action using transfer operators. The argument consists of two steps. First, the contour of integration is deformed so that the associated transfer operator is a perturbation of a normal one. Then the transfer operator is studied using methods of semi-classical analysis. In this paper we concentrate on the second step, the main technical result being a semi-classical estimate for powers of an integral operator which is approximately normal.
description: 28 pp, improved the presentation
Technical overview and features of CXL.docx
Creators: name: nag, santhosh  nagaraj
Publisher: name: figshare
Year: 2023
Subjects: Mobile computing
High performance computing
Energy-efficient computing
Distributed systems and algorithms
Networking and communications
Operating systems
Performance evaluation
Distributed computing and systems software not elsewhere classified

description: CXL (Compute Express Link) technology is a relatively new high-speed interconnect standard that was developed to enable faster communication between CPUs, GPUs, and other high-performance components in data center systems. The purpose of this paper is to provide a comprehensive technical overview of CXL technology, including its features, advantages, and potential applications in the modern data center environment.
Functional Meyer-Tanaka Formula
Creators: name: Saporito, Yuri F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H25, 60H07

description: The functional Ito formula, firstly introduced by Bruno Dupire for continuous semimartingales, might be extended in two directions: different dynamics for the underlying process and/or weaker assumptions on the regularity of the functional. In this paper, we pursue the former type by proving the functional version of the Meyer-Tanaka Formula. Following the idea of the proof of the classical time-dependent Meyer-Tanaka formula, we study the mollification of functionals and its convergence properties. As an example, we study the running maximum and the max-martingales of Yor and Obloj.
description: 26 pages, 2 figures
Light on the Infinite Group Relaxation
Creators: name: Basu, Amitabh
name: Hildebrand, Robert
name: Köppe, Matthias
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 90C10

description: This is a survey on the infinite group problem, an infinite-dimensional relaxation of integer linear optimization problems introduced by Ralph Gomory and Ellis Johnson in their groundbreaking papers titled "Some continuous functions related to corner polyhedra I, II" [Math. Programming 3 (1972), 23-85, 359-389]. The survey presents the infinite group problem in the modern context of cut generating functions. It focuses on the recent developments, such as algorithms for testing extremality and breakthroughs for the k-row problem for general k >= 1 that extend previous work on the single-row and two-row problems. The survey also includes some previously unpublished results; among other things, it unveils piecewise linear extreme functions with more than four different slopes. An interactive companion program, implemented in the open-source computer algebra package Sage, provides an updated compendium of known extreme functions.
description: 45 pages
title: Reformation und Gegenreformation im Stift Melk
Creators: name: Oberleitner, Jasmin
Year: 2022

description: Der Konfessionskonflikt, der neben sozialen Spannungen im 16. und 17. Jahrhundert in Europa Unruhen und Krieg auslöste, wirkte sich auch auf das Leben im Stift Melk und den umliegenden Herrschaften aus. Ein signifikanter Bevölkerungsteil des Ortes wandte sich ab etwa 1550 dem Luthertum zu und verlangte nach Mitsprache in Glaubensfragen. Auch viele der Bediensteten im Kloster waren dem Protestantismus zugetan, was zu Konflikten mit den Konventualen führte. Da die Reformatoren eine stark antimonastische Einstellung pflegten, fiel es dem Kloster schwer neue Ordensgeistliche aufzunehmen. Darüber hinaus kam es zu Konflikten und in einigen Fällen zu gewalttätigen Ausschreitungen zwischen den protestantischen Marktbewohnern und dem Pfarrer. Neben der Kirchenspaltung kam es aber auch zu Vermischungen zwischen katholischen und protestantischen Bräuchen. Vielen Zeitgenossen waren die Unterschiede und Abgrenzungen zwischen den Konfessionen nicht klar. Der Melker Abt war gleichzeitig Stiftsvorsteher sowie Markt- und Grundherr von Melk gewesen, beide Aufgabenbereiche waren nicht immer leicht zu vereinen: Er musste für die Aufrechterhaltung des katholischen Glaubens in Stift und Ort sorgen, als Grundherr hatte er aber auch die Verantwortung für das harmonische Zusammenleben und die wirtschaftliche Situation der ihm anvertrauten Untertanen. In der Konfessionalisierungszeit waren sowohl die habsburgischen Landesfürsten als auch die Äbte und die weltlichen Grundherren zu Konzessionen gezwungen: Im Falle Melks war es nicht möglich, nur katholische Diener im Kloster anzustellen und als Grund- und Marktherren wollte die Melker Äbte Auswanderungen protestantischer Untertanen möglichst vermeiden. In Melk begann die Rekatholisierung mit der Amtszeit des Abtes Caspar Hofmann 1587. Dieser konnte den Verfall des Klosters durch verbesserte Buchführung, Ausbildung der Konventualen und strenge Überwachung der Klosterdisziplin heben. Nicht zufällig decken sich die Erfolge des Gegenreformators Hofmann mit der Vorantreibung der Gegenreformation von landesfürstlicher Seite seit 1576. Die Klostererneuerung Hofmanns war so erfolgreich gewesen, dass man nach 1600 kaum noch Konfessionskonflikte in den Melker Akten findet. Bei der Belagerung Melks durch aufständische Protestanten 1619 waren keine Marktbewohner interessiert sich den Angreifern anzuschließen.
Logarithmic violation of scaling in strongly anisotropic turbulent transfer of a passive vector field
Creators: name: Antonov, N. V.
name: Gulitskiy, N. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences
subject: 76F30

description: Inertial-range asymptotic behavior of a vector (e.g., magnetic) field, passively advected by a strongly anisotropic turbulent flow, is studied by means of the field theoretic renormalization group and the operator product expansion. The advecting velocity field is Gaussian, not correlated in time, with the pair correlation function of the form $\propto δ(t-t') / k_{\bot}^{d-1+ξ}$, where $k_{\bot}=|{\bf k}_{\bot}|$ and ${\bf k}_{\bot}$ is the component of the wave vector, perpendicular to the distinguished direction (`direction of the flow') -- the $d$-dimensional generalization of the ensemble introduced by Avellaneda and Majda [{\it Commun. Math. Phys.} {\bf 131}: 381 (1990)]. The stochastic advection-diffusion equation for the transverse (divergence-free) vector field includes, as special cases, the kinematic dynamo model for magnetohydrodynamic turbulence and the linearized Navier--Stokes equation. In contrast to the well known isotropic Kraichnan's model, where various correlation functions exhibit anomalous scaling behavior with infinite sets of anomalous exponents, here the dependence on the integral turbulence scale $L$ has a logarithmic behavior: instead of power-like corrections to ordinary scaling, determined by naive (canonical) dimensions, the anomalies manifest themselves as polynomials of logarithms of $L$. The key point is that the matrices of scaling dimensions of the relevant families of composite operators appear nilpotent and cannot be diagonalized. The detailed proof of this fact is given for correlation functions of arbitrary order.
description: 30 pages, LaTeX source, 7 eps figures. Extended version: new abstracts A and B, numerous minor improvements in text
Area Disadvantage and Intimate Partner Homicide: An Ecological Analysis of North Carolina Counties, 2004–2006
Creators: name: Halpern, Carolyn Tucker
name: Madkour, Aubrey Spriggs
name: Schoenbach, Victor J.
name: Martin, Sandra L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Using data from the North Carolina Violent Death Reporting System and other sources, we examined ecologic relationships between county (n=100) disadvantage and intimate partner homicide (IPH), variability by victim gender and county urbanicity, and potential mediators. County disadvantage was related to female-victim homicide only in metropolitan counties (incidence rate ratio [IRR] 1.25); however, disadvantage was associated with male-victim IPH regardless of county urbanicity (IRR 1.17). None of the potential intervening variables examined (shelter availability, intimate partner violence services’ funding), was supported as a mediator. Results suggest disparities across North Carolina counties in IPH according to county disadvantage. Future research should explore other potential mediators (i.e., service accessibility and law enforcement responses), as well as test the robustness of findings using additional years of data.
Comorbidities of chronic prurigo A systematic review and meta-analysis
Creators: name: Yin, Mengting
name: Yang, Chener
name: Guo, Yang
name: Yang, Xu
name: Dou, Xia
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320205
subject: Dermatology

description: Background: Chronic prurigo (CPG) is an inflammatory skin disease. Comorbidities including dermatological, cardiovascular, and psychiatric diseases have been reported in patients with CPG, however, the evidence has not been systematically evaluated. We aim to summarize the comorbidities, discuss underlying pathogenesis, and highlight the evaluation of CPG patients.Methods: We performed a systematic search using PubMed, Embase, and Web of Science databases for all articles reporting possible associated diseases with CPG. Pooled random-effects odds ratios (OR) with 95% CI were calculated.Results: A total of 17 studies were included in this systematic review. Statistically significant association(P<0.05) with CPG has been demonstrated with atopic diseases: atopic dermatitis (pooled OR, 10.91; 95% CI, 3.65-32.67), allergic rhinitis (2.66;1.12-6.27), asthma (3.23;1.55-6.74); infectious diseases: hepatitis B (pooled OR, 2.15; 95% CI, 1.11-4.14); endocrine diseases: diabetes (pooled OR, 4.93; 95% CI, 1.13-21.56), type 1 diabetes 2.46;2.16-2.81), type 2 diabetes (1.89;1.34-2.68), hyperlipoproteinemia (2.90; 1.61-5.22); cardiovascular diseases: heart failure (pooled OR, 4.13; 95% CI, 1.15-14.91), hypertension (3.17;1.56-6.45); respiratory system diseases: chronic obstructive pulmonary disease (pooled OR, 3.19; 95% CI, 1.42-7.16); urinary system diseases: chronic kidney disease (pooled OR, 4.16; 95% CI, 1.79-9.66); digestive system disease: inflammatory bowel disease (pooled OR, 2.06; 95% CI, 1.26-3.36); and others: osteoporosis (pooled OR, 3.08; 95% CI, 1.70-5.59), thyroid disease (1.70;1.17-2.47).Conclusion: CPG is associated with various systemic disorders. Recognition of comorbidities is critical to the appropriate management of affected patients.
Anger-Related Dysregulation as a Factor Linking Childhood Physical Abuse and Interparental Violence to Intimate Partner Violence Experiences
Creators: name: McLaughlin, Katie A.
name: Monson, Candice M.
name: Iverson, Katherine M.
name: Adair, Kathryn C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Childhood family violence exposure is associated with increased risk for experiencing intimate partner violence (IPV) in adulthood, but the mechanisms underlying this relationship remain inadequately understood. Difficulties with emotion regulation may be one factor that helps to explain this relationship.
Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases
Creators: name: Burga, Ana M.
name: Lininger, Ruth A.
name: Fadare, Oluwole
name: Tavassoli, Fattaneh A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The current investigation was conducted to evaluate the proportional distribution of the various histologic subtypes (including newly recognized variants) of male breast carcinomas, to determine whether any histologic subtypes occur with a frequency that is markedly discordant with the expected frequencies from published data on parallel female breast tumors. We also aimed to document the distribution of malignancies metastatic to the breast. Seven hundred fifty-nine archived cases of primary invasive carcinoma involving the male breast were retrieved and subcategorized into histologic subtypes according to contemporary criteria. Six hundred forty-three (84.7%) tumors were pure infiltrating ductal carcinoma (IDC) not otherwise specified. The most common of the remainder included papillary carcinoma with invasion in the form of IDC (n = 34), mixed IDC and mucinous carcinoma (n = 26), and pure mucinous carcinoma (n = 21). In 19 cases, metastases from other sites involved the breast, most commonly (58%) cutaneous melanoma. Invasive carcinoma of the male breast appears to display a morphologic spectrum and distribution of histologic subtypes that is comparable to those of the female breast, with some expected variation. Compared with published experience on their female counterparts, there is a two-fold increase in the frequency of invasive papillary carcinoma in the male breast. Finally, the most common tumor metastatic to the male breast in this series was cutaneous melanoma.
Averaging in random systems of nonnegative matrices
Creators: name: Mierczyński, Janusz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37H15, 15B48 (Primary), 92D25 (Secondary)

description: It is proved that for the top Lyapunov exponent of a random matrix system of the form $\{A D(ω)\}$, where $A$ is a nonnegative matrix and $D(ω)$ is a diagonal matrix with positive diagonal entries, is bounded from below by the top Lyapunov exponent of the averaged system. This is in contrast to what one should expect of systems describing biological metapopulations.
description: 8 pages
Consequences of omitting spin-orbit partner configurations on B(E2)'s and quadrupole moments in nuclei
Creators: name: Zamick, Larry
name: Sharon, Yitzhak
name: Robinson, Shadow
name: Harper, Matthew
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Calculations of B(E2)'s and quadruplole moments in the g_{9/2 region below ^{100} Sn are hampered by the fact that the inclusion of the g_{7/2}configuration leads to model spaces that are too large to handle. We therefore examine lighter nuclei if the fp region where one can easily include all the orbitals, f,{}_{7/2}, p_{3/2}, p_{1/2}and f_{5/2} . We perform such calculations but then take a step back and exclude the f_{5/2} orbital. By comparing the 2 calculations we can hope to get insight into the importance of the missing spin-orbit partner in other regions.
A Leucine Zipper Motif in the Cytoplasmic Domain of gp41 Is Required for HIV-1 Replication and Pathogenesis in Vivo
Creators: name: Miller, Eric D.
name: Kao, Sandra M.
name: Su, Lishan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: A leucine zipper motif is conserved in the cytoplasmic domain of glycoprotein gp41 (gp41c) of all HIV-1 subtypes, but is not present in HIV-2 or SIV. The second leucine residue of the leucine zipper was mutated (L95R) to determine the role of this motif in HIV-1 replication and pathogenesis. The L95R mutant replicated to wild-type levels in activated peripheral blood mononuclear cells and CEMx174 cells. However, L95R replication was impaired in SupT1 cells and in the SCID-hu Thy/Liv mouse. Although the infectivity of wild-type virions and that of L95R mutant virions were equally sensitive to heat treatment, we found that L95R produced more defective virions, due to reduced surface expression and virion incorporation of the env glycoprotein. These results suggest that the L95 residue in the leucine zipper of gp41c of HIV-1 plays an important role in the env expression and virion incorporation that is required for viral replication and pathogenesis in the SCID-hu Thy/Liv mouse. The leucine zipper motif in gp41c may provide a novel anti-HIV-1 target.
Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope
Creators: name: Duus, Karen M.
name: Yu, Xiao-Fang
name: Su, Lishan
name: Gao, Feng
name: Meissner, Eric G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. One of the isolates (R3A) exhibited markedly rapid kinetics of replication and thymocyte depletion. These phenotypes mapped to the envelope, as a recombinant NL4-3 virus encoding the R3A envelope had similar phenotypes, even in the absence of nef. Notably, the viruses with high pathogenic activity in the thymus (R3A and NL4-R3A) did not show enhanced replication or cytopathicity in PHA-stimulated PBMCs. Furthermore, NL4-R3A did not enhance replication of the coinfected NL4-3 virus in the thymus, suggesting an intrinsic advantage of the R3 A envelope. The R3 A envelope showed higher entry activity in infecting human T cells and in depleting CD4+ thymocytes when expressed in trans. These data suggest that SI viruses with unique envelope functions which can overcome barriers to transmission may hasten disease progression by perturbing T cell homeostasis.
Thymic pathogenicity of an HIV-1 envelope is associated with increased CXCR4 binding efficiency and V5-gp41-dependent activity, but not V1/V2-associated CD4 binding efficiency and viral entry
Creators: name: Coffield, Vernon M.
name: Meissner, Eric G.
name: Su, Lishan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We previously described a thymus-tropic HIV-1 envelope (R3A Env) from a rapid progressor obtained at the time of transmission. An HIV-1 molecular recombinant with the R3A Env supported extensive replication and pathogenesis in the thymus and did not require Nef. Another Env from the same patient did not display the same thymus-tropic pathogenesis (R3B Env). Here, we show that relative to R3B Env, R3A Env enhances viral entry of T cells, increases fusion-induced cytopathicity, and shows elevated binding efficiency for both CD4 and CXCR4, but not CCR5, in vitro. We created chimeric envelopes to determine the region(s) responsible for each in vitro phenotype and for thymic pathogenesis. Surprisingly, while V1/V2 contributed to enhanced viral entry, CD4 binding efficiency, and cytopathicity in vitro, it made no contribution to thymic pathogenesis. Rather, CXCR4 binding efficiency and V5-gp41-associated activity appear to independently contribute to thymic pathogenesis of the R3A Env. These data highlight the contribution of unique HIV pathogenic factors in the thymic microenvironment and suggest that novel mechanisms may be involved in Env pathogenic activity in vivo.
Structure and immunogenicity of alternative forms of the simian immunodeficiency virus gag protein expressed using Venezuelan equine encephalitis virus replicon particles
Creators: name: West, Ande
name: Davis, Nancy L.
name: Whitmore, Alan
name: Moore, Dominic T.
name: Collier, Martha
name: Swanstrom, Ronald
name: Cecil, Chad
name: Madden, Victoria
name: Johnston, Robert
name: Jurgens, Christy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Venezuelan equine encephalitis virus replicon particles (VRP) were engineered to express different forms of SIV Gag to compare expression in vitro, formation of intra- and extracellular structures and induction of humoral and cellular immunity in mice. The three forms examined were full-length myristylated SIV Gag (Gagmyr+), full-length Gag lacking the myristylation signal (Gagmyr-), or a truncated form of Gagmyr- comprising only the matrix and capsid domains (MA/CA). Comparison of VRP-infected primary mouse embryo fibroblasts, mouse L929 cells and primate Vero cells showed comparable expression levels for each protein, as well as extracellular virus-like particles (VRP-Gagmyr+), and distinctive cytoplasmic aggregates (VRP-Gagmyr-) with each cell type. VPR were used to immunize BALB/c mice, and immune responses were compared using an interferon (IFN)-γ ELISPOT assay and a serum antibody ELISA. Although all three VRP generated similar levels of IFN-γ-producing cells at 1 week post-boost, at 10 weeks post-boost the MA/CA-VRP-induced response was maintained at a significantly higher level relative to that induced by Gagmyr+-VRP. Antibody responses to MA/CA-VRP and Gagmyr+-VRP were not significantly different.
Anomalous diffusion in fast cellular flows at intermediate time scales
Creators: name: Iyer, Gautam
name: Novikov, Alexei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 35B27 (Primary), 35R60, 60H30, 76R50 (Secondary)

description: It is well known that on long time scales the behaviour of tracer particles diffusing in a cellular flow is effectively that of a Brownian motion. This paper studies the behaviour on "intermediate" time scales before diffusion sets in. Various heuristics suggest that an anomalous diffusive behaviour should be observed. We prove that the variance on intermediate time scales grows like $O(\sqrt{t})$. Hence, on these time scales the effective behaviour can not be purely diffusive, and is consistent with an anomalous diffusive behaviour.
description: 28 pages, 2 figures
title: Individualisierung - programmatische Falle im Umgang mit Heterogenität?
Creators: name: Richter, Sandra
Year: 2022

description: Die vorliegende Arbeit beschäftigt sich mit individualisierender Unterrichtsgestaltung als Antwort auf die Heterogenität von Schüler*innen. Mit einer steigenden Wahrnehmung und Thematisierung der Heterogenität in Schule und Unterricht geht die Frage nach dem adäquaten Umgang mit eben dieser einher. Beantwortet wird diese Frage in vielen Diskussionen mit dem Schlagwort Individualisierung. Diesbezüglich wurden zahlreiche Handreichungen und Empfehlungen verfasst, die eben Methoden einer solchen individualisierten Unterrichtsgestaltung für Lehrer*innen beschreiben. Bereits der Titel der Masterarbeit lässt vermuten, dass die Antwort auf die Frage nach dem Umgang mit Heterogenität im schulischen Unterricht, nicht unhinterfragt hinzunehmen ist. Ziel dieser Arbeit ist es, Möglichkeiten und Grenzen einer individualisierenden Unterrichtsgestaltung aus Erfahrung von in der Praxis tätigen Lehrer*innen aufzuzeigen. Im ersten Teil der Arbeit wird die Thematik auf Basis von Fachliteratur bearbeitet. Die Erfahrungen und Einschätzungen der Lehrer*innen werden durch leitfadengestützte Interviews erhoben und mithilfe der Dokumentarischen Interpretation ausgewertet. Die Ergebnisse zeigen einen merklichen Unterschied in den Möglichkeiten des Ausmaßes von Individualisierung der Schüler*innen zwischen verschiedenen Bereichen der Lehrer*innentätigkeit. Die Möglichkeiten zur Individualisierung sind in jenen Handlungen größer, die sich auf die Unterrichts- und Tagesstrukturierung beziehen, wohin Grenzen auftreten, sobald der Leistungsaspekt in den Fokus rückt. Dabei zeigen sich die spürbarsten Grenzen aufgrund von bestimmten Handlungsdiskursen in welchen die Lehrer*innen verortet sind.
Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge
Creators: name: Liao, Hua-Xin
name: Johnston, Robert E.
name: Thornburg, Natalie J.
name: Pickup, David J.
name: Ray, Caroline A.
name: Collier, Martha L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: An anti-poxvirus vaccine based on replicon particles of Venezuelan equine encephalitis virus (VRP) is being developed. The cowpox virus genes encoding structural proteins corresponding to vaccinia virus proteins A33, B5, and A27 were each expressed from VRP. High serum IgG titers against these proteins were generated in BALB/c mice vaccinated with each of these VRP. VRP induced both IgG1 and IgG2a with a strong predominance of IgG2a production. The response is long-lasting, as evidenced by the retention of high anti-B5 serum IgG titers through at least 50 weeks after priming immunization. Mice vaccinated with B5-, A33- or A27-VRP individually or together survived intranasal challenge with cowpox virus, with the multivalent vaccine formulation providing more effective protection from weight loss and clinical signs of illness than the monovalent vaccines. These results demonstrate that VRP may provide an effective alternative to vaccinia virus vaccines against poxvirus infection.
Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases
Creators: name: Wilton, Brianne A.
name: Barry, Michele
name: Van Buuren, Nicholas
name: Xiong, Yue
name: Furukawa, Manabu
name: Campbell, Stephanie
name: Garneau, Robyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Cellular proteins containing BTB and kelch domains have been shown to function as adapters for the recruitment of substrates to cullin-3-based ubiquitin ligases. Poxviruses are the only family of viruses known to encode multiple BTB/kelch proteins, suggesting that poxviruses may modulate the ubiquitin pathway through interaction with cullin-3. Ectromelia virus encodes four BTB/kelch proteins and one BTB-only protein. Here we demonstrate that two of the ectromelia virus encoded BTB/kelch proteins, EVM150 and EVM167, interacted with cullin-3. Similar to cellular BTB proteins, the BTB domain of EVM150 and EVM167 was necessary and sufficient for cullin-3 interaction. During infection, EVM150 and EVM167 localized to discrete cytoplasmic regions, which co-localized with cullin-3. Furthermore, EVM150 and EVM167 co-localized and interacted with conjugated ubiquitin, as demonstrated by confocal microscopy and co-immunoprecipitation. Our findings suggest that the ectromelia virus encoded BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3 potentially functioning to recruit unidentified substrates for ubiquitination.
A philistine vector of digital transformation / Обывательский вектор цифровой трансформации.
Creators: name: Simashenkov, Pavel
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 390201
subject: Education policy
classificationCode: 390203
subject: Sociology of education
classificationCode: 441008
subject: Sociology of culture
classificationCode: 470102
subject: Communication technology and digital media studies

description: The relevance of the topic is due to the emergence of the so-called digital skeptics who challenge the need for total digitalization of education. The object of the study is the values of digital transformation, the subject — their actual implementation in the system of higher education. The author has chosen an axiological approach to the study of the problem, involving the consideration of the digitalization of education in the socio-philosophical aspect. According to the author, the bonuses of Reality 2.0 are predominantly of an entertainment nature, which has nothing to do with research activities. In addition, most of the materials on the digital world in one way or another raise the topic of salesmanship. This means that the key direction of technology development is purely commercial, a priori consumer-oriented. In the spirit of concreteness and pragmatics, the vector of simplification is declared the only correct and universally applicable. The most dangerous simplifications are: 1) identifying knowledge with information and information with data; 2) identifying creativity with creativity; 3) identifying reality with reality. The author is confident: it is superfluous to argue that constructive criticism of digitalization has nothing to do with obscurantism. Protest is not so much against the numbers themselves, as against the neo-Lysenkovism (show pedagogy and other forms of profanation), zealously promoted by the adherents of the IT breakthrough. By defending the principles of classical pedagogy, digital skeptics defend culture from dogmatism and utilitarian primitivization.
CXL overview
Creators: name: nag, santhosh  nagaraj
Publisher: name: figshare
Year: 2023
Subjects: Mobile computing
High performance computing
Energy-efficient computing
Distributed systems and algorithms
Networking and communications
Operating systems
Performance evaluation
Distributed computing and systems software not elsewhere classified

description: CXL (Compute Express Link) technology is a relatively new high-speed interconnect standard that was developed to enable faster communication between CPUs, GPUs, and other high-performance components in data center systems. The purpose of this paper is to provide a comprehensive technical overview of CXL technology, including its features, advantages, and potential applications in the modern data center environment.
Effects of rapid antigen degradation and VEE glycoprotein specificity on immune responses induced by a VEE replicon vaccine
Creators: name: Moore, D.T.
name: Collier, M.L.
name: Fu, K.
name: Davis, N.L.
name: Moshkoff, D.A.
name: West, A.
name: Johnston, R.E.
name: Whitmore, A.C.
name: Tang, Y.
name: Swanstrom, R.
name: Fluet, M.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Genetic vaccines are engineered to produce immunogens de novo in the cells of the host for stimulation of a protective immune response. In some of these systems, antigens engineered for rapid degradation have produced an enhanced cellular immune response by more efficient entry into pathways for processing and presentation of MHC class I peptides. VEE replicon particles (VRP), single cycle vaccine vectors derived from Venezuelan equine encephalitis virus (VEE), are examined here for the effect of an increased rate of immunogen degradation on VRP vaccine efficacy. VRP expressing the matrix capsid (MA/CA) portion of SIV Gag were altered to promote rapid degradation of MA/CA by various linkages to co-translated ubiquitin or by destabilizing mutations and were used to immunize BALB/c mice for quantitation of the anti-MA/CA cellular and humoral immune responses. Rapid degradation by the N-end rule correlated with a dampened immune response relative to unmodified MA/CA when the VRP carried a glycoprotein spike from an attenuated strain of VEE. In contrast, statistically equivalent numbers of IFNγ+ T-cells resulted when VRP expressing unstable MA/CA were packaged with the wild-type VEE glycoproteins. These results suggest that the cell types targeted in vivo by VRP carrying mutant or wild type glycoprotein spikes are functionally different, and are consistent with previous findings suggesting that wild-type VEE glycoproteins preferentially target professional antigen presenting cells that use peptides generated from the degraded antigen for direct presentation on MHC.
Optical Manipulation of Quantum Dot Electron Spin Qubits Using Microcavity Quantum Well Exciton-Polaritons
Creators: name: Puri, Shruti
name: McMahon, Peter L.
name: Yamamoto, Yoshihisa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this paper we introduce and analyze a new system design for quantum-dot-based qubits that simultaneously supports scalable one-qubit and two-qubit gates, and single-shot qubit measurement. All three key processes (one-qubit gates, two-qubit gates, and qubit measurement) rely on the interaction between the electron in each quantum dot and exciton-polaritons formed in a quantum well situated near the quantum dots. A key novel feature of our proposed system is the use of polariton traps, which we show enhances the quantum-dot--quantum-well interaction by a factor of 10 and consequently results in $100 \times$ faster two-qubit gates. We also introduce a novel one-qubit gate that is based on a combination of optical and microwave control, which is supported in the same device and system configuration as the other operations, in contrast to the conventional one-qubit gate that is based on all-optical control.
Self-intersecting fuzzy extra dimensions from squashed coadjoint orbits in ${\cal N}=4$ SYM and matrix models
Creators: name: Steinacker, Harold C.
name: Zahn, Jochen
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We find new vacuum solutions of ${\cal N}=4$ super-Yang-Mills with totally anti-symmetric cubic soft SUSY breaking terms, or equivalently solutions of the IKKT matrix model of type $\mathbb{R}^4_θ\times {\cal K}_N$ with flux terms. The solutions can be understood in terms of 4- and 6- dimensional fuzzy branes ${\cal K}_N$ in extra dimensions, describing self-intersecting projections of compact flag manifolds of $SU(3)$. The 6-dimensional solutions provide a 6-fold covering of the internal space near the origin, while the 4-dimensional branes have a triple self-intersections spanning all 6 internal directions. The solutions have lower energy than the trivial vacuum, and we prove that there are no negative modes. The massless modes are identified explicitly. In particular there are chiral fermionic zero modes, linking the coincident sheets with opposite flux at the origin. They have a $\mathbb{Z}_3$ family symmetry, originating from the Weyl group rotations.
description: 28+8 pages, 2 figures. V2: improved discussion, published version
The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation
Creators: name: Mainou, Bernardo A.
name: Raab-Traub, Nancy
name: Everly, David N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: LMP1 induces the expression of two members of the family of Id proteins, Id1 and Id3, and affects cell cycle regulation by decreasing the expression of the cyclin dependent kinase inhibitor, p27, and increasing levels and phosphorylation of cdk2 and Rb. In the present study, the contribution of the Id proteins to LMP1-mediated transformation was determined. Although LMP1 effectively inhibited p27 expression, the Id proteins alone did not affect expression of p27, cdk2, and Rb. Neither Id1 nor Id3 was sufficient to transform Rat-1 cells and inhibition of Id1 expression did not affect LMP1-induced morphologic transformation of Rat-1 cells or reduction of p27. However, reduced Id expression resulted in smaller foci and impaired the growth rate of Rat-1 cells. These data indicate that overexpression of the Id proteins is not sufficient for the effects of LMP1 on the cell cycle but that inhibition of Id expression does affect the growth of LMP1-transformed and parental Rat1 cells.
title: Freiheit des Straßenbildes
Creators: name: Schwaiger, Valentina Teresa
Year: 2022

description: Die Freiheit des Straßenbildes, die in § 54 Abs 1 Z 5 UrhG gesetzlich verankert wurde, stellt eine Schranke des Urheberrechts dar, da sie eine vergütungs- und zustimmungsfreie Werknutzung von ausgeführten Baukunstwerken und anderen Werken der bildenden Künste erlaubt, die sich bleibend an einem öffentlichen Ort befinden. Bereits seit 1895 ist eine vergleichbare Schranke im österreichischen UrhG vorhanden. Im Jahr 2001 wurde durch die InfoSoc-RL den Mitgliedstaaten der Europäischen Union (MS) ermöglicht, die freie Werknutzung in nationale Gesetze aufzunehmen. Bislang wurde dies von den MS unterschiedlich angenommen: so wurde die freie Werknutzung einerseits sehr weitgefasst, andererseits auf eine bestimmte Nutzung einge-schränkt oder gar nicht aufgenommen. Durch die unterschiedlichen nationalen gesetzlichen Bestimmungen der MS zur Freiheit des Straßenbildes besteht oftmals Unklarheit, insbesondere bei NutzerInnen der Freiheit des Straßenbildes, da durch eine Ver-öffentlichung im Internet uU verschiedene Rechtslagen zur Anwendung kommen können. In der vorliegenden Arbeit werden die Unterschiede der gesetzlichen Bestimmungen bespielhaft dargestellt. Dafür wurde neben der österreichischen Freiheit des Straßenbildes, die deutsche und französische Panoramafreiheit ausgewählt. Anschließend wird auf die Harmonisierungsversuche, die es in der Vergangenheit bereits gab, eingegangen. Bislang wurde vom europäischen Gesetzgeber schlussendlich kein Harmonisierungsversuch umgesetzt. Alternative Lösungsmaßnahmen, etwa die Einführung einer Kulturflatrate, werden verglichen mit einer Harmonisierung durch einen einheitlichen Rechtsrahmen, als schwerer durchführbar eingestuft. Es ist nicht zu erwarten, dass MS mit einer eher konservativen Einstellung zur Freiheit des Straßenbildes eine Einführung bzw Ausweitung der gesetzlichen Grundlage zur Freiheit des Straßenbildes ohne weiteres annehmen werden. Ein einheitlicher gesetzlicher Rahmen zur Freiheit des Straßenbildes ist jedoch insbesondere für die Informationsgesellschaft dringend nötig, sodass ein Mittelmaß in Kauf genommen müssen wird, um schlussendlich mehr Rechtssicherheit erlangen zu können.