cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Floronia exornata L.Koch 1878
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Floronia
Floronia exornata

description: Floronia exornata (L.Koch, 1 878) ** Tao et al., 1995: f. 61-68: Saaristo, 1996: f. 14, 16, 18. Material examined: 1 ♀, [14] Oblachnava Mt, 1600-1750 m, 43º34'N 134º12'E, 3.08.1998, YM; 1 ♀; [17] Lazovski Reserve, Korpad’ Camp, 43º16'N 134º08'E, 6- 9.08.1998, YM; 4 ♂ ♀, [21] Khasan Distr, env. of Andreevka Vill, 42º35—36'N 131º13'E, 11- 15.08.1998, YM; 5 ♀♀, env. of Vladivostok, 43º20.92'N 132º03.05'E, 4.10.1998, YM; 1 ♀, [13] 43º52'N 134º17'E, Pravaya Izvilinka Riv, 2.08.1998 YM; 4 ♂ ♀, [10] S part Ussuri Reserve, 43º39'N 132º33'E, 29- 31.07.1998, YM. COMMENTS. The first record in the province. Mongolo- Manchurian nemoral range: from Tuva [Marusik et al., 2000] lo Japan [Yaginuma, 1977], to the south to Yunnan, China [Li & Tao, 1995]. Earlier confused with sibling European species F. bucculenta (Clerck, 1757).
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 61, DOI: 10.5281/zenodo.822713
description: {"references": ["Tao Y, Li S. Q, Zhu C. D. 1995. Linyphiid spiders of Changbai mountains, China (Aranaeae: Linyphiidae: Linyphiinae) / / Beitr. Araneol. Bd. 4 (for 1994). P. 241 - 288.", "Saaristo M L 1996. Notes on the Japanese species of the genera Tapinopa and floronia (Arachnida: Araneae: Linyphiidae: Micronetinae) / / Acta Arachnol. Vol. 45. No. l. P. l- 6.", "Marusik Yu. M., Logunov D. V, Koponen S. 2000. Spiders of Tuva, South Siberia. Magadan: IBPN FEB RAS. 252 pp.", "Yaginuma T. 1977. A list of Japanese spiders (revised in 1977) / / Acta Arachnol. Vol. 27. Spec. No. P. 367 - 406."]}
The tympanic membrane: Highly developed smooth muscle arrays in the annulus fibrosus of mustached bats
Creators: name: Henson, Miriam M.
name: Henson, O.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The annulus fibrosus tympanicus is the thickened peripheral rim of the pars tensa of the tympanic membrane. It is an area into which the connective tissue matrix of the membrane extends to attach to the tympanic bone (ring). Light microscopy, SEM, TEM and confocal microscopy were used to study the area in mustached bats Pteronotus p. parnellii,P. p. portoricensis and P. quadridens. In cross sections of the annulus morphologically distinct apical and basal or myovascular zones could be recognized. The apical zone had a collagenous matrix that was continuous with the pars tensa. The myovascular zone contained an extensive network of thin-walled endothelial tubes and a well-developed array of radially arranged smooth muscle cells that filled the interval between the vessels. The muscle tissue occupied the interval between the densely collagenous “apical zone” and the bony tympanic ring and was closely associated with bundles of unmyelinated nerve fibers. The structure and arrangement of the tissue suggests a highly developed specialization for the tonic control of tension of the pars tensa and a system that potentially regulates sound transmission to the middle and inner ear.
Lepthyphantes zygius Tanasevitch 1993
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Lepthyphantes
Lepthyphantes zygius

description: Lepthyphantes zygius Tanasevitch, 1 993 Lepthyphanteszygius Tanasevitch, 1993: l,f. 1-7 (holotypecf, and paratypes ♀♀ in ZMMU, examined); . Lepthyphantes dentatus Tao, Li & Zhu, 1995: 248, f. 98-105, syn.n. Material examined: 1 ♀. Lazovski Reserve, America Kordon 43º16.5'N 134º03'E, 14- 17.05.1999, YS. COMMENTS. Judjing to the illustrations and specimens examined, as well as to type localities of L. zygius and L. dentatus (in bordering provinces), their synonymy is quite obvious. Not found outside Jilin, China and the Maritime Province, Russia.
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 61, DOI: 10.5281/zenodo.822713
description: {"references": ["Tao Y, Li S. Q, Zhu C. D. 1995. Linyphiid spiders of Changbai mountains, China (Aranaeae: Linyphiidae: Linyphiinae) / / Beitr. Araneol. Bd. 4 (for 1994). P. 241 - 288."]}
title: Interface Investigations of the Si | Cu and Si | Ag Contact with Respect to the Photoelectrochemical Performance
Creators: name: Schäfer, Céline
Publisher: name: UNSPECIFIED
Year: 2020

description: Due to the worldwide growth of industry nations, the need of energy has drastically increased within the last decades. In order to save our environment and decrease global warming, the development of new renewable energy systems is essential. Here, natural photosynthesis acts as the role model for the successful conversion and storage of the sun’s energy. One emerging technology to achieve a solar to fuel conversion is a photoelectric catalytic cell, which is able to convert CO2 directly into fuels. The first essential part of such a device is the photoabsorber, which has to drive the electrochemical reaction. In this work Si single- and multijunctions serve as photoabsorber material. Different surface terminations were prepared: hydrogen capped as well as native and thermally grown SiO2 as passivating interlayers. The second important part of the direct photoelectrochemical device is an appropriate catalyst, which allows high current densities at low overpotentials when being in contact with a suitable electrolyte. As metallic Cu is known to be able to reduce CO2 to CH4, C2H4 and alcohols in aqueous electrolytes, electron beam deposited metallic Cu is used as catalyst in the different model systems. For understanding the electrochemical performance of such a direct photoelectrochemical device, it is necessary to analyze the electronic structure of the interface between its two main components- the Si junction acting as the photoabsorber and the Cu thin film as catalyst. Therefore, the interface was investigated by X-ray photoelectron spectroscopy (XPS) analysis after the stepwise deposition of Cu onto the Si surface with different surface terminations. Furthermore, cyclic voltammetry (CV) was used to determine the electrochemical (EC) performance in an aqueous 0.3 M KHCO3 electrolyte solution. As an alternative model system the Si | Ag interface was investigated with respect to the photoelectrochemical performance. The aim of this work is to achieve a basic understanding on how the different band alignments due to the different surface terminations impact the CO2 reduction reaction.
Le secteur social : un espace pour l'innovation économique au Maroc
Creators: name: EL ADLOUNI, Wafaa
Publisher: name: Zenodo
Year: 2023
Subjects: Innovation ; RSE ; Entreprise ; secteur social ; Economie

description: La notion d'innovation sociale est utilisée de façon croissante pour répondre aux défis sociaux et environnementaux tout en favorisant la croissance. Même si la question du profit reste un objectif primordial pour l'entreprise, la recherche du profit qui conditionne sa durabilité économique, ne se fait pas au détriment des dimensions environnementales et sociales liées à la notion de développement. La croissance ciblée ne se limite pas à une croissance des profits à court terme mais suppose plutôt la croissance d'une performance globale de l'entreprise qui comprend différents objectifs conformes aux attentes des différentes parties prenantes : clients, ONG, actionnaires, pouvoirs publics…
En partenariat avec l'Etat et les associations, les entreprises marocaines privées doivent dépasser les modèles traditionnels pour aborder la tâche plus rude de l'innovation.
A Research Software Engineering workflow for OpenFOAM in university research groups
Creators: name: Schwarzmeier, Moritz
name: Marić, Tomislav
name: Tolle, Tobias
name: Gläser, Dennis
name: Lehr, Jan-Patrick
name: Pappagianidis, Ioannis
name: Lambie, Benjamin
name: Bothe, Dieter
name: Bischof, Christian
Publisher: name: Zenodo
Year: 2023
Subjects: research software engineering
software engineering
research data management
continuous integration
research software

description: We present a Research Software Engineering (RSE) workflow for developing research software in Computational Science and Engineering (CSE) in university research groups. Their members have backgrounds from different scientific disciplines and often no education in RSE. Research software development lasts many years, contrary to team members leaving regularly. Combining and re-using ideas and results from others is a fundamental principle of science. In CSE research software embodies research ideas. As CSE research advances, research software should grow sustainably over the years. To increase the sustainability of research software, our workflow simplifies the investigation and integration of research ideas, ensures reproducibility and new functionality does not impair existing one. These practices speed up research and increase the quality of scientific output. Our CSE-RSE workflow is simple, effective and largely ensures the FAIR principles.The workflow uses established practices and tools, pragmatically adapted for CSE research software: version-control, secondary-data standards, continuous integration and containerization.
description: Video available at https://youtu.be/CnwU5iDCzVI?t=19
description: {"references": ["https://knowledge-base.nfdi4ing.de/"]}
Gap Duration Discrimination in Listeners with Cochlear Hearing Loss: Effects of Gap and Marker Duration, Frequency Separation, and Mode of Presentation
Creators: name: Hall III, Joseph W.
name: Grose, John H.
name: Buss, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: This study examined the effects of cochlear hearing loss on gap duration discrimination (GDD), with particular interest in whether cochlear hearing loss results in increased difficulty for across-channel temporal judgments. The hypothesis being tested was that listeners with cochlear loss would perform as well as normal-hearing listeners for all within-channel conditions but would exhibit relatively greater performance deficits in the across-channel conditions. A subsidiary aim was to determine whether, in normal-hearing listeners, the across-channel effects previously observed for minimal-duration standard gaps also existed for relatively long standard gaps. Two experiments were undertaken, one dealing with monaural conditions and one dealing with dichotic conditions. The monaural results indicated that across-frequency GDD was poorer than isofrequency GDD, even for the longer gap durations of 35 and 250 ms examined here. However, the results showed no effect of hearing loss on GDD. Rather, GDD appeared to be sensitive to listener age, with younger listeners showing better performance in both within-channel and across-channel conditions. In addition, both within-channel and across-channel performance was sensitive to the duration of the leading gap marker. Finally, the pattern of dichotic "across-ear" performance was similar, but not equivalent, to that of monaural across-frequency performance.
Hair Cell Death in a Hearing-Deficient Canary
Creators: name: Presson, Joelle C.
name: Dooling, Robert J.
name: Popper, Arthur N.
name: Wilkins, Heather R.
name: Ryals, Brenda M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of this relationship still need to be better understood. The Belgian Waterslager (BWS) canary is an ideal system in which to study cell death and subsequent cell division. In contrast to mixed breed (MB) canaries, cell division normally occurs in the auditory end organ of the BWS without any external manipulation. In addition, some of the cells in the auditory epithelium may be dying through an apoptotic-like process. In the present study two methods were used to quantify dying cells in the BWS and MB canary auditory epithelia: morphological criteria and TUNEL. Results confirm that some of the abnormal hair cells in the BWS auditory epithelium are apoptotic-like. The presence of both cell death and cell division indicates that these processes act concurrently in the adult end organ. Future studies are needed to determine if cell death is a stimulus for the observed cell division.
Age- and Size-Related Changes in the Inner Ear and Hearing Ability of the Adult Zebrafish (Danio rerio)
Creators: name: Wilkins, Heather R.
name: Souza, Marcy J.
name: Presson, Joelle C.
name: Higgs, Dennis M.
name: Popper, Arthur N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Fishes, unlike most other vertebrate groups, continue to add sensory hair cells to their ears for much of their lives. However, it is not clear whether the addition ever stops or how the addition of sensory cells impacts hearing ability. In this article, we tested both questions using the zebrafish, Danio rerio. Our results not only have important implications for understanding the consequences of adding sensory receptors, but these results for normal zebrafish also serve as valuable baseline information for future studies of select mutations on the ear and hearing of this species. Our results show that hair cell production continues in uncrowded zebrafish up to 10 months of age (about one-third of a normal life span), but despite this addition there is no change in hearing sensitivity or bandwidth. Therefore, hearing is not related to the number of sensory cells in the ear in juvenile and adult animals. We also show that despite no net addition of hair cells after about 10 months, hair cells are still being produced, but at a lower rate, presumably to replace cells that are dying. Moreover, crowding of zebrafish has a marked impact on the growth of the fish and on the addition of sensory cells to the ear. We also demonstrate that fish size, not age, is a better indicator of developmental state of zebrafish.
The Effect of Temporal Stimulus Characteristics in Maintenance of the Acoustic Reflex
Creators: name: Hall, Joseph W.
name: Buss, Emily
name: Chung, Brian J.
name: Grose, John H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: In normal listeners, acoustic reflex decay (ARD) typically occurs for high- but not for low-frequency tones. In patients with acoustic neuromas, decay can be obtained at all frequencies, presumably due to poor neural synchrony. These observations have led us to hypothesize that resistance to decay is due to robust encoding of temporal fine structure of the eliciting stimulus. For a 4-kHz stimulus, ARD is reduced by sinusoidal amplitude modulation (SAM), a result attributed to the low-frequency pattern of SAM providing the temporal characteristics necessary to maintain the reflex. If this interpretation is correct, then further reductions in ARD should be seen for stimuli having temporal characteristics that even more closely resemble the neural response to low-frequency stimulus fine structure. On the other hand, if other perceptual qualities of a SAM tone are responsible for the effect (e.g., rate pitch), then manipulations of perceived sound quality, rather than temporal characteristics per se, should produce similar effects. The experiment reported here included a reference condition, (1) 5-kHz pure tone, and three "temporal" manipulations, composed of a 5-kHz tone multiplied by (2) a raised 100-Hz sinusoid, (3) a noise sample, lowpass filtered at 100 Hz, and (4) a half-wave rectified 100-Hz sinusoid. Additional conditions manipulated perceived pitch. These stimuli spanned 4.5-8 kHz, including a reference condition, (5) Gaussian noise, and a stimulus associated with a 100-Hz pitch, (6) iterated rippled noise. Results show the greatest reductions in ARD with the half-wave rectified stimulus, thought to most closely mimic the temporal characteristics of a low-frequency tone. Little or no reduction in ARD was associated with the iterated rippled noise, suggesting that perceived pitch does not play an important role in maintaining the acoustic reflex.
Neserigone basarukini Eskov 1992
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Neserigone
Neserigone basarukini

description: Neserigone basarukini Eskov, 1992 * Material examined: 3 ♀♀, [09] env. of Anisimovka Vill, 43º10'N 132º46'E, 24- 28.07.1998, YM; 8 ♀♀, [10] S part Ussuri Reserve, 43º39'N 132º33'E. 29- 31.07.1998, YM. COMMENTS. The first record in the province and the easternmost point of distribution. Photo 46 (page 56) in Chikuni [1989] does not correspond to N. nigroterminorum (as listed) but to the N. basarukini Eskov (type species of the genus). Therefore, N. basarukini occurs not only in Sakhalin, South Kuriles [Eskov, 1994] and the Maritime Province (present data), but also in Japan. Erigonidium nigriterminorum Oi, 1960 was transferred into Neserigone by Eskov [1992].
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 61, DOI: 10.5281/zenodo.822713
description: {"references": ["Eskov K. Yu. 1992. A restudy of the generic composition of the linyphiid spidenfauna of the Far East (Araneida: Linyphi- idae) / / F. ntomol. Scand. Vol. 23. P. 153 - 168.", "Chikuni Y. 1989. Pictorial encyclopedia of spiders in Japan. Tokyo: Kaiseisha Publ. 308 pp. [in Japanese]", "Eskov K. Yu, 1994. Catalogue of the linyphiid spiders of northern Asia (Arachnida, Araneae, Linyphiidae). Sofia-Moscow: PEN - SOFT Publ. 144 pp.", "Oi R. 1960. Linyphiid spiders ofJapan / / J. Inst. Polytechn. Osaka Univ., Ser. D. Vol. ll. P. 137 - 244."]}
Integrated single nucleus and spatial transcriptomics in the human dorsolateral prefrontal cortex
Creators: name: Huuki-Myers, Louise A.
name: Spangler, Abby
name: Eagles, Nicholas J.
name: Montgomery, Kelsey D.
name: Kwon, Sang Ho
name: Boyi Guo
name: Grant-Peters, Melissa
name: Divecha, Heena R.
name: Tippani, Madhavi
name: Chaichontat Sriworarat
name: Nguyen, Annie B.
name: Prashanthi Ravichandran
name: Tran, Matthew N.
name: Seyedian, Arta
name: PsychENCODE Consortium
name: Hyde, Thomas M.
name: Kleinman, Joel E.
name: Battle, Alexis
name: Page, Stephanie C.
name: Ryten, Mina
name: Hicks, Stephanie C.
name: Martinowich, Keri
name: Collado-Torres, Leonardo
name: Maynard, Kristen R.
Publisher: name: F1000 Research Limited
Year: 2023

description: The dorsolateral prefrontal cortex (DLPFC) is a brain region critical to many functions including working memory, cognitive flexibility, and planning. A defining feature of the DLPFC is its six histological layers, each containing a unique distribution of cell types and connections with other cortical layers and brain regions. To study the spatial organization and cell type populations of the DLPFC we built the first, large-scale, paired Visium spatial gene expression (n=30), and single nucleus RNA-seq (n=19) dataset from ten neurotypical donors.
 In the Visium data we identified data-driven spatial domains with an unsupervised clustering method, revealing cortical sub-layers and non-laminar features such as vasculature. Single nucleus RNA-seq data added single cell resolution to the molecular map. Cell type populations were spatially registered to manually annotated layers (Maynard et al, Nature Neuroscience, 2021) with resources from the spatialLIBD Bioconductor package (Pardo et al, BMC Genomics, 2021). We systematically assigned histological layer identities to the excitatory neurons, resulting in 13 layer-resolution cell type populations. The paired datasets were leveraged to perform spot deconvolution and cell-cell communication analyses.
 Using PsychENCODE and publicly available data, we map the enrichment of cell types and genes associated with neuropsychiatric disorders to discrete spatial domains. Finally, we provide resources for the scientific community to explore these integrated spatial and single cell datasets at research.libd.org/spatialDLPFC and spatialLIBD::fetch_data().
Temporal Coding by Cochlear Nucleus Bushy Cells in DBA/2J Mice with Early Onset Hearing Loss
Creators: name: Wang, Yong
name: Manis, Paul B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The bushy cells of the anterior ventral cochlear nucleus (AVCN) preserve or improve the temporal coding of sound information arriving from auditory nerve fibers (ANF). The critical cellular mechanisms entailed in this process include the specialized nerve terminals, the endbulbs of Held, and the membrane conductance configuration of the bushy cell. In one strain of mice (DBA/2J), an early-onset hearing loss can cause a reduction in neurotransmitter release probability, and a smaller and slower spontaneous miniature excitatory postsynaptic current (EPSC) at the endbulb synapse. In the present study, by using a brain slice preparation, we tested the hypothesis that these changes in synaptic transmission would degrade the transmission of timing information from the ANF to the AVCN bushy neuron. We show that the electrical excitability of bushy cells in hearing-impaired old DBA mice was different from that in young, normal-hearing DBA mice. We found an increase in the action potential (AP) firing threshold with current injection; a larger AP afterhyperpolarization; and an increase in the number of spikes produced by large depolarizing currents. We also tested the temporal precision of bushy cell responses to high-frequency stimulation of the ANF. The standard deviation of spikes (spike jitter) produced by ANF-evoked excitatory postsynaptic potentials (EPSPs) was largely unaffected in old DBA mice. However, spike entrainment during a 100-Hz volley of EPSPs was significantly reduced. This was not a limitation of the ability of bushy cells to fire APs at this stimulus frequency, because entrainment to trains of current pulses was unaffected. Moreover, the decrease in entrainment is not attributable to increased synaptic depression. Surprisingly, the spike latency was 0.46 ms shorter in old DBA mice, and was apparently attributable to a faster conduction velocity, since the evoked excitatory postsynaptic current (EPSC) latency was shorter in old DBA mice as well. We also tested the contribution of the low-voltage-activated K+ conductance (gKLV) on the spike latency by using dynamic clamp. Alteration in gKLV had little effect on the spike latency. To test whether these changes in DBA mice were simply a result of continued postnatal maturation, we repeated the experiments in CBA mice, a strain that shows normal hearing thresholds through this age range. CBA mice exhibited no reduction in entrainment or increased spike jitter with age. We conclude that the ability of AVCN bushy neurons to reliably follow ANF EPSPs is compromised in a frequency-dependent fashion in hearing-impaired mice. This effect can be best explained by an increase in spike threshold.
Identification of mutation hotspots to measure carcinogenic risk in Barrett's Esophagus using seq.hotSPOT and compSPOT
Creators: name: Grant, Sydney R.
name: Rosario, Spencer R.
name: Sampson, Ella M.
name: Foster, Barbara A.
name: Wei, Lei
name: Huss, Wendy J.
name: Gyorgy  Paragh
Publisher: name: F1000 Research Limited
Year: 2023

description: In 2022, an estimated 20,000 new cases of esophageal adenocarcinoma (ESAD) were reported, with little decline over the last few decades, highlighting the need for cancer prevention. Barrett’s Esophagus (BE) is a precursor lesion to ESAD, with a reported risk of progression from 0.2-13.4% per patient per year. There is a lack of tools to accurately differentiate BE likely to progress to advanced disease. ESAD and BE have shown clonal mutations in known cancer-causing genes, including TP53, CDKN2A, ARID1A, PIK3CA, and SMAD4. We have developed a computational tool, seq.hotSPOT, to identify highly mutated genomic regions in various tissue types. Using whole-exome sequencing data from 6 cBioPortal datasets of ESAD and esophageal squamous cell carcinoma (ESCC) samples, we identified the top 10% most mutated genomic regions in each cancer subtype with seq.hotSPOT. Our tool compSPOT was then used to identify significantly mutated genomic hotspots in ESAD and ESCC, showing 5 hotspots in TP53 for ESCC and 9 hotspots within TP53 and CDKN2A in ESAD. Highly mutated genomic regions showed a significant correlation (p < 0.00001) between samples of clinically normal esophageal epithelium and both ESAD and ESCC. The correlation of mutated regions between BE found to progress to ESAD and BE with no observed disease progression were compared to ESAD samples. A significant correlation (p < 0.00001) was found in both cases, however, a higher correlation was observed in progressive BE compared to non-progressive (R = 0.836, R = 0.4924, respectively). The number of mutations present in BE samples found within the 9 mutation hotspots in ESAD was measured for progressive and non-progressive BE, revealing significantly more mutations within the progressive BE samples (p < 0.01). The ESAD mutation hotspots were then used as features in a machine learning model to classify BE samples as either progressive or non-progressive. The BE dataset was split into training and test data, following training of a neural network model, the performance of the model was measured based on the test dataset yielding an AUC of 0.7857. The relative variable importance was calculated for each hotspot, and the most influential hotspot in this classification model was located on TP53 chr17:7577022-7577121. seq.hotSPOT and compSPOT provide an efficient pipeline for identifying genomic areas of high mutation sensitivity, and future studies with larger cohort sizes may identify additional significant hotspot markers for the prediction of disease progression. The addition of personal risk factors of Esophageal Adenocarcinoma as features in machine learning model may increase the accuracy of a classification algorithm.
Open Targets: identifying drug targets in a pre-competitive framework
Creators: name: Carvalho-Silva, Denise
Publisher: name: F1000 Research Limited
Year: 2020

description: In this talk, I introduce Open Targets, a public-private partnership to expedite drug target identification and prioritisation for reduced attrition rates in drug discovery. I then focus on one of the open source and open access products created by Open Targets, namely the Open Targets Platform and highlight some of its use cases. I conclude my talk with two examples of experimental work carried out by Open Targets in oncology and diseases of the immune system.
An Electric Frequency-to-place Map for a Cochlear Implant Patient with Hearing in the Nonimplanted Ear
Creators: name: Skinner, Margaret
name: Holden, Timothy
name: Dorman, Michael F.
name: Loiselle, Louise
name: Gifford, Rene
name: McKarns, Sharon
name: Spahr, Tony
name: Finley, Charles
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The aim of this study was to relate the pitch of high-rate electrical stimulation delivered to individual cochlear implant electrodes to electrode insertion depth and insertion angle. The patient (CH1) was able to provide pitch matches between electric and acoustic stimulation because he had auditory thresholds in his nonimplanted ear ranging between 30 and 60 dB HL over the range, 250 Hz to 8 kHz. Electrode depth and insertion angle were measured from high-resolution computed tomography (CT) scans of the patient’s temporal bones. The scans were used to create a 3D image volume reconstruction of the cochlea, which allowed visualization of electrode position within the scala. The method of limits was used to establish pitch matches between acoustic pure tones and electric stimulation (a 1,652-pps, unmodulated, pulse train). The pitch matching data demonstrated that, for insertion angles of greater than 450 degrees or greater than approximately 20 mm insertion depth, pitch saturated at approximately 420 Hz. From 20 to 15 mm insertion depth pitch estimates were about one-half octave lower than the Greenwood function. From 13 to 3 mm insertion depth the pitch estimates were approximately one octave lower than the Greenwood function. The pitch match for an electrode only 3.4 mm into the cochlea was 3,447 Hz. These data are consistent with other reports, e.g., Boëx et al. (2006), of a frequency-to-place map for the electrically stimulated cochlea in which perceived pitches for stimulation on individual electrodes are significantly lower than those predicted by the Greenwood function for stimulation at the level of the hair cell.
Neural and Behavioral Sensitivity to Interaural Time Differences Using Amplitude Modulated Tones with Mismatched Carrier Frequencies
Creators: name: Roberts, Jason M.
name: Blanks, Deidra A.
name: Buss, Emily
name: Hall, Joseph W.
name: Fitzpatrick, Douglas C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Bilateral cochlear implantation is intended to provide the advantages of binaural hearing, including sound localization and better speech recognition in noise. In most modern implants, temporal information is carried by the envelope of pulsatile stimulation, and thresholds to interaural time differences (ITDs) are generally high compared to those obtained in normal hearing observers. One factor thought to influence ITD sensitivity is the overlap of neural populations stimulated on each side. The present study investigated the effects of acoustically stimulating bilaterally mismatched neural populations in two related paradigms: rabbit neural recordings and human psychophysical testing. The neural coding of interaural envelope timing information was measured in recordings from neurons in the inferior colliculus of the unanesthetized rabbit. Binaural beat stimuli with a 1-Hz difference in modulation frequency were presented at the best modulation frequency and intensity as the carrier frequencies at each ear were varied. Some neurons encoded envelope ITDs with carrier frequency mismatches as great as several octaves. The synchronization strength was typically nonmonotonically related to intensity. Psychophysical data showed that human listeners could also make use of binaural envelope cues for carrier mismatches of up to 2–3 octaves. Thus, the physiological and psychophysical data were broadly consistent, and suggest that bilateral cochlear implants should provide information sufficient to detect envelope ITDs even in the face of bilateral mismatch in the neural populations responding to stimulation. However, the strongly nonmonotonic synchronization to envelope ITDs suggests that the limited dynamic range with electrical stimulation may be an important consideration for ITD encoding.
Ostearius melanopygius O. Pickard-Cambridge 1879
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Ostearius
Ostearius melanopygius

description: Ostearius melanopygius (O.Pickard-Cambridge, 1879) ** Roberts, 1987: f. 55a. Material examined: 3 ♀♀ (ZMMU), Lazovskv Reserve, Petrova Kordon, 42º52'N 133º48'E, 19 - 20.09.1998, YS. COMMENTS. The first record ofthe species and genus in Russia. Almost Cosmopolitan range. Though several reports of this species were made from adjacent Japan [Chikuni, 1989], China [Song et al., 1999], and Finland [Huhta et al., 1979], it was never found within the territory of the former Soviet Union [Mikhailov, 1997].
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 61, DOI: 10.5281/zenodo.822713
description: {"references": ["Roberts M. J. 1987. The spiders of Great Britain and Ireland. Volume 2. Linyphiidae and checklist. Essex, Harley Books; Martins. 204 pp.", "Chikuni Y. 1989. Pictorial encyclopedia of spiders in Japan. Tokyo: Kaiseisha Publ. 308 pp. [in Japanese]", "Song DX, Zhu, M. S, Chen, J. 1999. The spiders of China. Hebei Science & Technology Press. 640 pp.", "Huhta V., Ikonen E \" Vilkamaa P. 1979. Succession of invertebrate populations in artificial soil made of sewage sludge and crushed bark / / Ann. Zool. Fennici. Vol. 16. No. 4. P. 223 - 270.", "Mikhailov K. G. 1997. Catalogue of the spiders of the territories of the former Soviet Union / / Sbornik trudov Zool. Muz. MGU. Vol. 37. 416 pp."]}
Erratum to: I h and HCN channels in murine spiral ganglion neurons: Tonotopic variation, local heterogeneity, and kinetic model (JARO - Journal of the Association for Research in Otolaryngology DOI: 10.1007/s10162-014-0446-z)
Creators: name: Manis, Paul B.
name: Davis, Robin L.
name: Liu, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: One of the major contributors to the response profile of neurons in the auditory pathways is the I h current. Its properties such as magnitude, activation, and kinetics not only vary among different types of neurons (Banks et al., J Neurophysiol 70:1420-1432, 1993; Fu et al., J Neurophysiol 78:2235-2245, 1997; Bal and Oertel, J Neurophysiol 84:806-817, 2000; Cao and Oertel, J Neurophysiol 94:821-832, 2005; Rodrigues and Oertel, J Neurophysiol 95:76-87, 2006; Yi et al., J Neurophysiol 103:2532-2543, 2010), but they also display notable diversity in a single population of spiral ganglion neurons (Mo and Davis, J Neurophysiol 78:3019-3027, 1997), the first neural element in the auditory periphery. In this study, we found from somatic recordings that part of the heterogeneity can be attributed to variation along the tonotopic axis because I h in the apical neurons have more positive half-activation voltage levels than basal neurons. Even within a single cochlear region, however, I h current properties are not uniform. To account for this heterogeneity, we provide immunocytochemical evidence for variance in the intracellular density of the hyperpolarization-activated cyclic nucleotide-gated channel α-subunit 1 (HCN1), which mediates I h current. We also observed different combinations of HCN1 and HCN4 α-subunits from cell to cell. Lastly, based on the physiological data, we performed kinetic analysis for the I h current and generated a mathematical model to better understand varied I h on spiral ganglion function. Regardless of whether I h currents are recorded at the nerve terminals (Yi et al., J Neurophysiol 103:2532-2543, 2010) or at the somata of spiral ganglion neurons, they have comparable mean half-activation voltage and induce similar resting membrane potential changes, and thus our model may also provide insights into the impact of I h on synaptic physiology.
How Does Rising House Price Influence Stock Market Participation in China?
Creators: name: Chen, Xiaoyu
name: Ji, Xiaohao
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: Stock Market
subject: Participation decision and depth
subject: House Price
subject: China
subject: CHFS data
subject: 330 Wirtschaft

description: This is an empirical study on the effect of house price on stock-market participation and its depths based on unique China Household Finance Survey (CHFS) data in 2011 and 2013 including 36213 sample households. We mainly found that, with an increase of one thousand RMB per square meter in macro house price, the probability to participate in the stock market will increase by 5.4% before controlling for wealth effect and 2.84% afterwards, indicating the existence of wealth effect. The participation depths of the stock-total asset ratio is expected to decrease by 0.23% and absolute stock asset is observed to decrease by 5.8 thousand RMB in response to one thousand RMB increase of per square meter house price. The effect of house price on participation decision is also related to housing area, and the negative effect of house price on stock market participation depths gets more intense with the increase of the stock-total asset ratio.
Appendix from Evolutionary game theory and the adaptive dynamics approach: adaptation where individuals interact
Creators: name: Avila, Piret
name: Mullon, Charles
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60801 Animal Behaviour
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Evolutionary game theory and the adaptive dynamics approach have made invaluable contributions to understanding how gradual evolution leads to adaptation when individuals interact. Here, we review some of the basic tools that have come out of these contributions to model the evolution of quantitative traits in complex populations. We collect together mathematical expressions that describe directional and disruptive selection in class- and group-structured populations in terms of individual fitness, with the aims of bridging different models and interpreting selection. In particular, our review of disruptive selection suggests there are two main paths that can lead to diversity: (i) when individual fitness increases more than linearly with trait expression; (ii) when trait expression simultaneously increases the probability that an individual is in a certain context (e.g. a given age, sex, habitat, size or social environment) and fitness in that context. We provide various examples of these and more broadly argue that population structure lays the ground for the emergence of polymorphism with unique characteristics. Beyond this, we hope that the descriptions of selection we present here help see the tight links among fundamental branches of evolutionary biology, from life history to social evolution through evolutionary ecology, and thus favour further their integration.This article is part of the theme issue ‘Half a century of evolutionary games: a synthesis of theory, application and future directions’.
BUSINESS, SOCIAL NETWORK, E-TRIBES E REALTÀ "VIRTUALI": ANALISI DI RICERCHE ETNOGRAFICHE SU PIATTAFORME SOCIALI DIGITALI
Creators: name: Moretti, Arianna
Publisher: name: Zenodo
Year: 2019
Subjects: ANTROPOLOGIA
SOCIAL NETWORK
NETNOGRAFIA
ETNOGRAFIA
E-TRIBES
REALTÀ VIRTUALI
BUSINESS

description: Tesi di laurea triennale conseguita presso l'Alma Mater Studiorum di Bologna (corso di laurea: Antropologia, Religioni, Civiltà Orientali) e discussa nella sessione di laurea di Luglio 2019. L' elaborato presenta una tesi compilativa su alcuni processi economici maturati nell'ambito di contesti sociali on-line, le loro evoluzioni e gli annessi impatti sulla vita degli utenti al di fuori degli stessi contesti "virtuali" in cui sono stati concepiti.
Pacifiphantes zakharovi Eskov & Marusik 1994
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Pacifiphantes
Pacifiphantes zakharovi

description: Pacifiphantes zakharovi Eskov & Marusik, 1994 Kaestneria rahmanni Tao, Li & Zhu, 1995:247, f. 82-90,syn.n. Material examined: 3 ♂ ♀, [13] 43º52'N 134º17'E, Pravaya Izvilinka Riv, 2.08.1998, YM; 3 ♂ ♀, [10] Ussuri Reserve, 43º39'N 132º33' E, 29- 31.07.1998, YM; 1 ♀, [09] env. of Anisimovka Vill., 43º10'N 132º46' E, 2 4 - 28.07.1998, YM; 168 ♂ ♀, several places in environs of Vladivostok, decidous forests, October 1997, YM; 1 ♀, Lazovski Reserve, Amcrica Kordon, 43º16.5'N 134º03'E, 14— 17.05.1999, YS; 1 ♂, Lazovski Reserve, kordon Proselochny, 43º00.5'N 134º08'E, 4— 6.10.1999, YS; 1 ♀, Ussuri Reserve, Turovaya Pad’ Campus, 9.05.1995, T.Vshivkova. COMMENTS. Judging to illustrations ofTao et al. [1995] and numerous specimens examined, as well as to the type localities of P. zakharovi and Kaestneria rahmanni (in bor­ dering provinces), their synonymy is quite obvious. In addi­ tion to the Maritime Province, Russia and Jilin, China, found also in Khabarovsk Province.
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 62, DOI: 10.5281/zenodo.822713
description: {"references": ["Eskov K. Yu, Marusik Yu. M. 1994. New data on the taxonomy and faunistics of North Asian linyphiid spiders (Aranei Linyphi- idae) / / Ibid. Vol. 2 (for 1993). No. 4. P. 41 - 79.", "Tao Y, Li S. Q, Zhu C. D. 1995. Linyphiid spiders of Changbai mountains, China (Aranaeae: Linyphiidae: Linyphiinae) / / Beitr. Araneol. Bd. 4 (for 1994). P. 241 - 288."]}
Performance of global assessments of hip, knee, and back symptom change
Creators: name: Kraus, Virginia B.
name: Allen, Kelli D.
name: Doherty, Michael
name: Renner, Jordan B.
name: Jordan, Joanne M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To compare patients’ global assessments of change in knee, hip, and back symptoms with actual changes over time in pain, function, and radiographic severity.
Appendix from Evolutionary game theory and the adaptive dynamics approach: adaptation where individuals interact
Creators: name: Avila, Piret
name: Mullon, Charles
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60801 Animal Behaviour
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Evolutionary game theory and the adaptive dynamics approach have made invaluable contributions to understand how gradual evolution leads to adaptation when individuals interact. Here, we review some of the basic tools that have come out of these contributions to model the evolution of quantitative traits in complex populations. We collect together mathematical expressions that describe directional and disruptive selection in class- and group-structured populations in terms of individual fitness, with the aims of bridging different models and interpreting selection. In particular, our review of disruptive selection suggests there are two main paths that can lead to diversity: (i) when individual fitness increases more than linearly with trait expression; (ii) when trait expression simultaneously increases the probability that an individual is in a certain context (e.g. a given age, sex, habitat, size or social environment) and fitness in that context. We provide various examples of these and more broadly argue that population structure lays the ground for the emergence of polymorphism with unique characteristics. Beyond this, we hope that the descriptions of selection we present here help see the tight links among fundamental branches of evolutionary biology, from life history to social evolution through evolutionary ecology, and thus favour further their integration.This article is part of the theme issue ‘Half a century of evolutionary games: a synthesis of theory, application and future directions’.
Pelecopsis nigroloba Fei, Gao & Zhu 1995
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Pelecopsis
Pelecopsis nigroloba

description: Pelecopsis nigroloba Fei, Gao & Zhu, 1995 ** Song et al., 1999: f. 115e-h. Material examined: 13 ♂♀ [10] S part Ussuri Reserve. 43º39'N 132º33'E, 29- 31.07.1998, YM; 9 ♂ ♀, [09] env. of Anisimovka Vill. 43º10'N 132º46'E, 24- 28.07.1998, YM; 14♂♀, [17] Lazcivski Reserve, Korpad' Camp, 43º16'N 134º08'E, 6— 9.08.1998, YM. COMMENTS. The first record in Russia, earlier known only from Jilin, China [Song et al., 1999],
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 62, DOI: 10.5281/zenodo.822713
description: {"references": ["Tao Y, Li S. Q, Zhu C. D. 1995. Linyphiid spiders of Changbai mountains, China (Aranaeae: Linyphiidae: Linyphiinae) / / Beitr. Araneol. Bd. 4 (for 1994). P. 241 - 288.", "Song DX, Zhu, M. S, Chen, J. 1999. The spiders of China. Hebei Science & Technology Press. 640 pp."]}
Predictors of medication non-adherence for vasculitis patients
Creators: name: DeVellis, Robert F.
name: Carpenter, Delesha M.
name: Hogan, Susan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The primary purpose of this article is to document whether demographic, clinical, regimen-related, intrapersonal, and interpersonal factors predict medication non-adherence for vasculitis patients. A secondary purpose is to explore whether adherence varies by medication type and whether patients experienced drug-related side effects. Vasculitis patients (n=228) completed online baseline and 3-month follow-up surveys. Demographic (age, gender, education, race, marital status, and insurance status), clinical (perceived vasculitis severity, disease duration, vasculitis type, and relapse/remission status), regimen-related (experience of side effects), intrapersonal (depressive symptoms), and interpersonal (adherence-related support from family and friends) factors were measured at baseline. Medication non-adherence was assessed at follow-up using the Vasculitis Self-Management Survey medication adherence sub-scale (α=0.89). Variables that significantly correlated (p<0.05) with non-adherence were included in a linear regression model to predict non-adherence. Younger age (r=−0.23, p<0.001), female sex (r=0.16, p<0.05), experience of side effects (r=0.15, p<0.05), and more depressive symptoms (r=0.22, p< 0.001) were associated with more medication non-adherence, In the regression model, younger age (β=−0.01, p=0.01) and more depressive symptoms (β=0.01 p=0.02) predicted worse adherence. For six out of eight vasculitis medication types, patients who experienced side effects were less adherent than patients who did not experience side effects. Multiple factors are associated with medication non-adherence for vasculitis patients. Providers should discuss medication adherence and drug-related side effects with vasculitis patients. Providers may want to particularly target younger patients and patients with clinical signs of depression.