cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Imaging evaluation of traumatic cervical spine injury
Creators: name: Dutra, Sofia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neuroradiology spine
subject: CT
subject: MR
subject: Digital radiography
subject: Computer Applications-General
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To identify the imaging features of major patterns of traumatic cervical spine injury , including those involving the cervical vertebral column, intervertebral discs, cervical spine ligaments and cervical spine cord, using different imaging methods...
Significant reduction of lattice thermal conductivity by electron-phonon interaction in silicon with high carrier concentrations: a first-principles study
Creators: name: Liao, Bolin
name: Qiu, Bo
name: Zhou, Jiawei
name: Huberman, Samuel
name: Esfarjani, Keivan
name: Chen, Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Electron-phonon interaction has been well known to create major resistance to electron transport in metals and semiconductors, whereas less studies were directed to its effect on the phonon transport, especially in semiconductors. We calculate the phonon lifetimes due to scattering with electrons (or holes), combine them with the intrinsic lifetimes due to the anharmonic phonon-phonon interaction, all from first-principles, and evaluate the effect of the electron-phonon interaction on the lattice thermal conductivity of silicon. Unexpectedly, we find a significant reduction of the lattice thermal conductivity at room temperature as the carrier concentration goes above 1e19 cm-3 (the reduction reaches up to 45% in p-type silicon at around 1e21 cm-3), a range of great technological relevance to thermoelectric materials.
description: 19 pages, 5 figures
Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding
Creators: name: Appella, Ettore
name: Riddle, David
name: Conti, Brian
name: Miller, Peter J.
name: Pazy, Yael
name: Collins, Edward J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The keystone of the adaptive immune response is T cell receptor (TCR) recognition of peptide presented by Major Histocompatibility Complex (pMHC) molecules. The co-crystal structure of AHIII TCR bound to the MHC, HLA-A2, showed a large interface with an atypical binding orientation. MHC mutations in the interface of the proteins were tested for changes in TCR recognition. From the range of responses observed, three representative HLA-A2 mutants, T163A, W167A, and K66A, was selected for further study. Binding constants and co-crystal structures of the AHIII TCR and the three mutants were determined. K66 in HLA-A2 makes contacts with both peptide and TCR and previously has been identified as a critical residue for recognition by numerous TCR. The K66A mutation resulted in the lowest AHIII T cell response and the lowest binding affinity, which suggests T cell response may correlate with affinity. Importantly, the K66A mutation does not affect the conformation of the peptide. The change in affinity appears to be due to a loss in hydrogen bonds in the interface as a result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop. Isothermal titration calorimetry confirmed the loss of hydrogen bonding by a large loss in enthalpy. Our findings are inconsistent with the notion that the CDR1 and CDR2 loops of the TCR are responsible for MHC restriction, while the CDR3 loops interact solely with the peptide. Instead, we present here a MHC mutation that does not change the conformation of the peptide, yet results in an altered conformation of a CDR3.
SPIRIT CHECKLIST FOR A PROSPECTIVE STUDY ON VISUAL ACUITY OUTCOMES AND COMPLICATIONS FOLLOWING ND-YAG LASER CAPSULOTOMY IN POSTERIOR CAPSULAR OPACIFICATION AT AVBRH HOSPITAL
Creators: name: GANDHI, ANAND
Publisher: name: Zenodo
Year: 2023
Subjects: Posterior capsular opacification, Patient Satisfaction, Visual Acuity Outcomes, Nd-YAG laser capsulotomy, Complications

description: SPIRIT CHECKLIST FOR A PROSPECTIVE STUDY ON VISUAL ACUITY OUTCOMES AND COMPLICATIONS FOLLOWING ND-YAG LASER CAPSULOTOMY IN POSTERIOR CAPSULAR OPACIFICATION AT AVBRH HOSPITAL
Terahertz response of patterned epitaxial graphene
Creators: name: Sorger, C.
name: Preu, S.
name: Schmidt, J.
name: Winnerl, S.
name: Bludov, Y. V.
name: Peres, N. M. R.
name: Vasilevskiy, M. I.
name: Weber, H. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the interaction between polarized terahertz (THz) radiation and micro-structured large-area graphene in transmission geometry. In order to efficiently couple the radiation into the two-dimensional material, a lateral periodic patterning of a closed graphene sheet by intercalation doping into stripes is chosen, yielding unequal transmittance of the radiation polarized parallel and perpendicular to the stripes. Indeed, a polarization contrast up to 20% is observed. The effect even increases up to 50% when removing graphene stripes in analogy to a wire grid polarizer. The polarization dependence is analyzed in a large frequency range from < 80 GHz to 3 THz, including the plasmon-polariton resonance. The results are in excellent agreement with theoretical calculations based on the electronic energy spectrum of graphene and the electrodynamics of the patterned structure.
title: A novel approach for zero material loss (zero flash) and uniform cross-section during friction stir welding of dissimilar thickness Cu and Al alloys
Creators: name: Shankar, Sachindra
name: Chattopadhyaya, Somnath
name: Mehta, Kush P.
name: Vilaça, Pedro
Publisher: name: Strathprints - University of Strathclyde
Year: 2024

description: A novel approach for getting a uniform weld cross-section and flash-free joint with the help of friction stir welding (FSW) is implemented. The influence of the tool tilt angle and rotational speed on the macrostructure, microstructure, and mechanical properties was investigated. Mechanical characterization techniques like an optical microscope, FESEM, profilometer, tensile test, bent test, and XRD analysis were used to evaluate the joint properties. A maximum tensile strength of 108.91 MPa was achieved, which led to a joint efficiency of 96.38 %. A maximum bending angle of 107˚ was achieved for samples S5 and S6. The Al/Cu mixed region in the stir zone displayed a maximum micro-hardness of 152.26 HV whereas a minimum micro-hardness of 33.57 HV was achieved in the HAZ along aluminium side. Welds prepared at a rotational speed of 540 RPM and a tool tilt angle of 4.5˚results in an almost flash-free joint.
title: Imaging of acute pelvic pain and dysuria in children and adolescents: Manifestation of rare urogenital disorders
Creators: name: Cerniauskaite, Reda
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Diagnostic procedure
subject: Ultrasound
subject: CT
subject: MR
subject: Emergency
subject: Genital / Reproductive system female
subject: Abdomen
subject: Acute
subject: Education and training
subject: Pelvic floor dysfunction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review uncommon urogenital disorders manifestingin childhood To illustrate the radiologic features of these conditions using MRIimaging technique To provide tips in order to avoid potential diagnostic...
5G-IANA - D2.1 Specifications of the 5G-IANA architecture
Creators: name: Alexis Aivaliotis
name: Amr Rizk
name: Claudio Russo
name: Daniele Brevi
name: David Alemany
name: David Martín-Sacristán
name: Dimitris Klonidis
name: Edoardo Bonetto
name: Eirini Liotou
name: Fotis Foukalas
name: Francesca Moscatelli
name: Gabriele Scivoletto
name: George Karagiannopoulos
name: Giada Landi
name: Giorgos Adamakis
name: Héctor Donat
name: Janez Sterle
name: Joerg Schaepperle
name: Konstantinos V. Katsaros
name: Manuel Fuentes
name: Marios Zinonos
name: Markus Wimmer
name: Matteo Andolfi
name: Nehal Baganal Krishna
name: Pasquale Marasco
name: Rudolf Susnik
name: Thanos Xirofotos
name: Theodoros Rokkas
name: Yann Garcia
Publisher: name: Zenodo
Year: 2023

description: This deliverable has the objective to provide the outcomes of the activities performed in Work Package (WP) 2 "Specifications". The activities included the design of the 5G-IANA Automotive Open Experimentation Platform (AOEP) and the requirements specification of each architecture layer. The specified 5G-IANA architecture capitalizes on the 5G prospect of being a unified multi-service platform by orchestrating Vertical Services based on virtualized network slices and coordination of distributed edge-to-cloud deployment.
The 5G-IANA AOEP aims to provide an open and flexible experimentation platform to third-parties developers (e.g., SMEs) that want to develop new 5G-based services devoted to the Automotive vertical. The availability of an easy-to-use experimentation environment can facilitate the launch of new services creating new market opportunities. Moreover, 5G-IANA will actively address the configuration of the 5G network (e.g., network slicing, edge resources, etc.) with the objective of supporting in the best way the requirements of the new services. In this way, it will be also possible to verify if the current 5G implementation can adequately satisfy the highly demanding performance requirements of Automotive services.
Exact Solutions for Non-Hermitian Dirac-Pauli Equation in an intensive magnetic field
Creators: name: Rodionov, Vasily N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The modified Dirac-Pauli equations, which are introduced by means of ${γ_5}$-mass factorization of the ordinary Klein-Gordon operator, are considered. We also take into account the interaction of fermions with the intensive homogenous magnetic field focusing attention to their (g-2) gyromagnetic factor. The basis of this approach is developing of methods for study of the structure of regions of unbroken $\cal PT$ symmetry of Non-Hermitian Hamiltonians which be no studied earlier. For that, without the use of perturbation theory in the external field the exact energy spectra are deduced with regard to spin effects of fermions. We also investigate the unique possible of experimental observability the non-Hermitian restrictions in the spectrum of mass consistent with the conjecture Markov about Maximal Mass. This, in principal will may allow to find out the existence of an upper limit value in spectrum masses of elementary particles and confirm or deny the significance of the Planck mass.
description: 27 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1404.0503
Structural Insights into Fibronectin Type III Domain-mediated Signaling
Creators: name: Cui, Cai Bin
name: Siddiqui, Adnan
name: Zuobi-Hasona, Kheir
name: Howard-Williams, Escher L.
name: Bencharit, Sompop
name: Sondek, John
name: Aukhil, Ikramuddin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The alternatively spliced type-III extradomain B (EIIIB) of Fibronectin (FN) is only expressed during embryogenesis, wound healing and tumorigenesis. The biological function of this domain remains unclear. We describe here the first crystal structure of the interface between alternatively-spliced domain EIIIB and its adjacent FN type-III domain 8 (FN B-8). The opened CC′ loop of EIIIB and the rotation and tilt of EIIIB domain allows good access to the FG loop of FN-8 which is normally hindered by the CC′ loop of FN-7. In addition, the AGEGIP sequence of the CC′ loop of EIIIB replaces the NGQQGN sequence of the CC′ loop of FN-7. Finally, the CC” loop of EIIIB forms an acidic groove with FN-8. These structural findings warrant future studies directed at identifying potential binding partners for FN B-8 interface, linking EIIIB to skeletal and cartilagenous development, wound healing, and tumorigenesis, respectively.
title: Volumetric CT perfusion technique for assessment of PTA outcome in patients with Critical Limb Ischemia: A feasibility study
Creators: name: Galanakis, Nikolaos
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Image verification
subject: Arteriosclerosis
subject: Contrast agent-intravenous
subject: Computer Applications-Detection, diagnosis
subject: Angioplasty
subject: Fluoroscopy
subject: CT-Quantitative
subject: CT-Angiography
subject: Interventional vascular
subject: Extremities
subject: Cardiovascular system
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Peripheral arterial disease (PAD) characterizes the impairment of blood flow to the limbs as a result of stenoses or occlusions of the lower limb arteries [1]. The prevalence of PAD is in the range of 3–10% [2] and the major risk factors are...
Appendix II: Project Work Breakdown Structure (WBS) for the Practical Teaching Case in BPM
Creators: name: Pádua, Silvia
name: Lourenção, Marina
name: Moreira, Sérgio
name: Ribeiro, Luiz Ricardo
Publisher: name: Zenodo
Year: 2023

description: Project Work Breakdown Structure (WBS) for the Practical Teaching Case in BPM
Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities
Creators: name: Eletr, Ziad M.
name: Purbeck, Carrie
name: Siderovski, David P.
name: Sammond, Deanne W.
name: Kuhlman, Brian
name: Kimple, Randall J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The ability to manipulate protein binding affinities is important for the development of proteins as biosensors, industrial reagents, and therapeutics. We have developed a structure-based method to rationally predict single mutations at protein-protein interfaces that enhance binding affinities. The protocol is based on the premise that increasing buried hydrophobic surface area and/or reducing buried hydrophilic surface area will generally lead to enhanced affinity if large steric clashes are not introduced and buried polar groups are not left without a hydrogen bond partner. The procedure selects affinity enhancing point mutations at the protein-protein interface using three criteria: 1) the mutation must be from a polar amino acid to a non-polar amino acid or from a non-polar amino acid to a larger non-polar amino acid, 2) the free energy of binding as calculated with the Rosetta protein modeling program should be more favorable than the free energy of binding calculated for the wild type complex and 3) the mutation should not be predicted to significantly destabilize the monomers. The Rosetta energy function emphasizes short-range interactions: steric repulsion, Van der Waals forces, hydrogen bonding, and an implicit solvation model that penalizes placing atoms adjacent to polar groups. The performance of the computational protocol was experimentally tested on two separate protein complexes; Gαi1 from the heterotrimeric G-protein system bound to the RGS14 GoLoco motif, and the E2, UbcH7, bound to the E3, E6AP from the ubiquitin pathway. 12 single-site mutations that were predicted to be stabilizing were synthesized and characterized in the laboratory. 9 of the 12 mutations successfully increased binding affinity with 5 of these increasing binding by over 1.0 kcal/mol. To further assess our approach we searched the literature for point mutations that pass our criteria and have experimentally determined binding affinities. Of the 8 mutations identified, 5 were accurately predicted to increase binding affinity, further validating the method as a useful tool to increase protein-protein binding affinities.
Criticality and Mott-glass phase in a disordered 2D quantum spin systems
Creators: name: Ma, Nvsen
name: Sandvik, Anders W.
name: Yao, Dao-Xin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We use quantum Monte Carlo simulations to study a disordered S=1/2 Heisenberg quantum spin model with three different nearest-neighbor interactions, J1<=J2<=J3, on the square lattice. We consider the regime in which J1 represents weak bonds, and J2 and J3 correspond to two kinds of stronger bonds (dimers) which are randomly distributed on columns forming coupled 2-leg ladders. When increasing the average intra-dimer coupling (J2+J3)/2, the system undergoes a Neel to quantum glass transition of the ground state and later a second transition into a quantum paramagnet. The quantum glass phase is of the gapless Mott glass type (i.e., in boson language it is incompressible at temperature T = 0), and we find that the temperature dependence of the uniform magnetic susceptibility follows the stretched exponential form x~exp(-b/T^alpha) with 0 < alpha < 1. At the Neel-glass transition we observe the standard O(3) critical exponents, which implies that the Harris criterion for the relevance of the disorder is violated in this system.
description: 11 pages, 15 figures
The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
Creators: name: Worthylake, David K.
name: Betts, Laurie
name: Chhatriwala, Mariya K.
name: Sondek, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Rho-family GTPases are activated by the exchange of bound GDP for GTP, a process that is catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of Dbl-family GEFs consists of a Dbl-homology (DH) domain followed almost invariantly by a pleckstrin-homology (PH) domain. The majority of the catalytic interface forms between the switch regions of the GTPase and the DH domain, but full catalytic activity often requires the associated PH domain. Although PH domains are usually characterized as lipid binding regions, they also participate in protein-protein interactions. For example, the DH-associated PH domain of Dbs must contact its cognate GTPases for efficient exchange. Similarly, the N-terminal DH/PH fragment of Trio, which catalyzes exchange on both Rac1 and RhoG, is four-fold more active in vitro than the isolated DH domain. Given continued uncertainty regarding functional roles of DH-associated PH domains, we have undertaken structural and functional analyses of the N-terminal DH/PH cassette of Trio. The crystal structure of this fragment of Trio bound to nucleotide-depleted Rac1 highlights the engagement of the PH domain with Rac1 and substitution of residues involved in this interface substantially diminishes activation of Rac1 and RhoG. Also, these mutations significantly reduce the ability of full-length Trio to induce neurite outgrowth dependent on RhoG activation in PC-12 cells. Overall, these studies substantiate a general role for DH-associated PH domains in directly engaging Rho GTPases for efficient guanine nucleotide exchange and support a parsimonious explanation for the essentially invariant linkage between DH and PH domains.
5G-IANA - D2.1 Specifications of the 5G-IANA architecture
Creators: name: Aivaliotis, Alexis
name: Rizk, Amr
name: Russo, Claudio
name: Brevi, Daniele
name: Alemany, David
name: Martín-Sacristán, David
name: Klonidis, Dimitris
name: Bonetto, Edoardo
name: Liotou, Eirini
name: Foukalas, Fotis
name: Moscatelli, Francesca
name: Scivoletto, Gabriele
name: Karagiannopoulos, George
name: Landi, Giada
name: Giorgos Adamakis
name: Donat, Héctor
name: Sterle, Janez
name: Joerg Schaepperle
name: Katsaros, Konstantinos V.
name: Fuentes, Manuel
name: Zinonos, Marios
name: Wimmer, Markus
name: Andolfi, Matteo
name: Krishna, Nehal Baganal
name: Marasco, Pasquale
name: Susnik, Rudolf
name: Xirofotos, Thanos
name: Rokkas, Theodoros
name: Garcia, Yann
Publisher: name: Zenodo
Year: 2022

description: [Deliverable pending final approval by the EC] This deliverable has the objective to provide the outcomes of the activities performed in Work Package (WP) 2 “Specifications”. The activities included the design of the 5G-IANA Automotive Open Experimentation Platform (AOEP) and the requirements specification of each architecture layer. The specified 5G-IANA architecture capitalizes on the 5G prospect of being a unified multi-service platform by orchestrating Vertical Services based on virtualized network slices and coordination of distributed edge-to-cloud deployment. The 5G-IANA AOEP aims to provide an open and flexible experimentation platform to third-parties developers (e.g., SMEs) that want to develop new 5G-based services devoted to the Automotive vertical. The availability of an easy-to-use experimentation environment can facilitate the launch of new services creating new market opportunities. Moreover, 5G-IANA will actively address the configuration of the 5G network (e.g., network slicing, edge resources, etc.) with the objective of supporting in the best way the requirements of the new services. In this way, it will be also possible to verify if the current 5G implementation can adequately satisfy the highly demanding performance requirements of Automotive services.
title: Diagnostic Iodine-123/131 whole body scan following radioactive remnant ablation in well differentiated papillary or follicular thyroid cancer: a diagnostic help or hindrance?
Creators: name: McGill, Maria
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Nuclear medicine
subject: Thyroid / Parathyroids
subject: Nuclear medicine conventional
subject: Diagnostic procedure
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: When a patient is diagnosed with differentiated papillary or follicular thyroid cancer they usually undergo pre-operative cross-sectional imaging. If appropriate the patient will then be referred to the surgical team for consideration of a total or...
On two optomechanical effects of laser-induced electrostriction in dielectric liquids
Creators: name: Gojani, Ardian B.
name: Bejtullahu, Rasim
name: Obayashi, Shigeru
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: This paper presents electrostriction from the phenomenological perspective, and gives details on two mechanical effects arising from laser-matter interaction. Electrostriction is the tendency of materials to compress in the presence of a varying electric field. In this paper, the investigated materials are polar and nonpolar dielectric liquids. It is stressed that the dominant factor is the time evolution of the laser pulse, which causes tensile stresses and acoustic waves. The study is supported by experimental realization of electrostriction, which can be detected only at favourable conditions (observed in water, but not in castor oil). This study will shed light in developing measurement techniques (e.g., laser-induced grating spectroscopy) and in explaining the onset of cavities and laser-induced liquid breakdown.
Computational Studies Reveal Phosphorylation-dependent Changes in the Unstructured R Domain of CFTR
Creators: name: He, Lihua
name: Dokholyan, Nikolay V.
name: Riordan, John R.
name: Hegedűs, Tamás
name: Serohijos, Adrian W.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP dependent chloride channel that is mutated in cystic fibrosis, an inherited disease of high morbidity and mortality. The phosphorylation of its ∼200 amino acid R domain by protein kinase A is obligatory for channel gating under normal conditions. The R domain contains more than ten PKA phosphorylation sites. No individual site is essential but phosphorylation of increasing numbers of sites enables progressively greater channel activity. In spite of numerous studies of the role of the R domain in CFTR regulation, its mechanism of action remains largely unknown. This is because neither its structure nor its interactions with other parts of CFTR have been completely elucidated. Studies have shown that the R domain lacks well-defined secondary structural elements and is an intrinsically disordered region of the channel protein. Here, we have analyzed the disorder pattern and employed computational methods to explore low energy conformations of the R domain. Specific disorder and secondary structure patterns detected suggest the presence of Molecular Recognition Elements (MoREs) that may mediate phosphorylation regulated intra- and inter-domain interactions. Simulations were performed to generate an ensemble of accessible R domain conformations. Although the calculated structures may represent more compact conformers than occur in vivo, their secondary structure propensities are consistent with predictions and published experimental data. Equilibrium simulations of a mimic of a phosphorylated R domain showed that it exhibited an increased radius of gyration. In one possible interpretation of these findings, by changing its size, the globally unstructured R domain may act as an entropic spring to perturb the packing of membrane-spanning sequences that constitute the ion permeability pathway and thereby activate channel gating.
title: Empfehlungen zur Digitalisierung in Lehre und Studium
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Fachkräfte
Studium und Lehre
Qualitätssicherung
Investitionen
Hochschulen
Kooperationen
Internationalisierung

description: In den vorliegenden Empfehlungen zeigt der Wissenschaftsrat auf, wie Lehre und Studium mit Hilfe digitaler Elemente qualitativ verbessert werden können. Er unterbreitet Vorschläge, wie Hochschulen die Digitalisierung strategisch für ihre Profilbildung einsetzen können. Bei der Digitalisierung handelt es sich um eine große Transformationsaufgabe, die die Mitwirkung von Hochschulen, Lehrenden und Studierenden und deren enge Kooperation erfordert. Nötig sind außerdem zusätzliche Investitionen seitens der Politik sowie starke Unterstützungsstrukturen.
title: Digitalisierung und Datennutzung für Gesundheitsforschung und Versorgung - Positionen und Empfehlungen | Positionspapier
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Medizin
Forschungsinfrastrukturen
Digitalisierung
Big Data
Gesundheitsforschung
Gesundheitsdatennutzung
Medizininformatik

description: Der Wissenschaftsrat stellt in seinem Positionspapier zur Digitalisierung und Datennutzung für Gesundheitsforschung und Versorgung einen großen Aufholbedarf fest. Er plädiert für einen chancenorientierten, forschungsfreundlichen Ansatz, bei dem Digitalisierung als Mittel zum Zweck gesehen wird und der Mensch im Zentrum steht. Die verschiedenen derzeit laufenden Initiativen und Maßnahmen sollen unter der strategischen Leitidee einer dezentralen, mit Forschung kompatiblen Gesundheitsdateninfrastruktur gebündelt werden. Standardisierung, Datenaustausch und Vernetzung der relevanten Akteure sowohl im Gesundheitssystem wie in der Forschung sind ebenso essentiell wie die Implementierung eines nationalen Gesundheitsdatenportals, die rasche Umsetzung eines Gesundheitsdatennutzungsgesetzes und die Ausschöpfung der von der EU-DSGVO gewährten Freiräume zur Nutzung sensibler Daten für Forschungszwecke.
title: Abdominal radiopacities on plain abdominal radiograph
Creators: name: Marques, Pedro
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Conventional radiography
subject: Education
subject: Calcifications / Calculi
subject: Foreign bodies

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate a variety of abdominal radiopacities on plain abdominal radiograph. To learn how to recognize abdominal radiopacities and accurately make a list of differential diagnoses. To demonstrate the important role of conventional radiology in...
Progettare insieme alle comunità la narrazione del patrimonio colpito dal terremoto: le potenzialità dell’ecosistema Wikimedia nel contesto universitario
Creators: name: Feliciati, Pierluigi
Publisher: name: P. Feliciati, Progettare insieme alle comunità la narrazione del patrimonio colpito dal terremoto: le potenzialità dell’ecosistema Wikimedia nel contesto universitario, «Il capitale culturale», 2020, n. 22, pp. 35-50
Year: 2020

description: Le responsabilità per la tutela e valorizzazione dell’eredità culturale ricadono su tutti i cittadini, specie se pensiamo alle aree interne e ai contesti di emergenza. Questo approccio apre diversi quesiti etici e operativi su come progettare una valorizzazione basata sui risultati della ricerca scientifica condividendoli con le comunità di eredità, su quali canali, quali linguaggi adottare, adottando l’approccio della public history. L’utopia dell’attivazione dell’intelligenza collettiva in rete ha dimostrato di avere buone possibilità se si guarda alle dimensioni e alla raggiunta qualità e popolarità dell’ecosistema Wikimedia. La condizione necessaria è che si accetti il patto della collaborazione tra pari, della ricerca della neutralità, dell’uso consapevole delle fonti, della libertà di riuso dei contenuti prodotti. Presso l’Università di Macerata, con il progetto Wiki: Appennino Centro Italia, si è provato ad investire su un percorso dal basso, che coinvolgesse docenti, studenti, stakeholders e cittadini per contribuire a una piattaforma di conoscenza sui territori colpiti dalla serie sismica del 2016, appoggiandosi ai servizi dell’ecosistema digitale collaborativo e aperto. Del progetto, in questo contributo si presentano i presupposti, le metodologie e i primi risultati, approfondendo come caso emblematico il laboratorio per la redazione delle voci di enciclopedia sul Museo di Visso e sulla Madonna del Voto di Paolo da Visso.
description: Cultural heritage and the collective responsibility for its protection and enhancement, especially considering the internal areas and the emergency contexts, open up several ethical and operational questions: how to disseminate the results of scientific research? Which channels, which languages to adopt and how can we actively involve as many citizens as possible? The utopia of activating collective intelligence on the Web has proven to have good chances if we look at the dimensions, quality and popularity of Wikimedia ecosystem. The indispensable conditions are the acceptance of peer collaboration, neutrality, freedom of reuse of the produced content, and awareness in the use of sources. At the University of Macerata, the Wiki: Appennino Centro Italia project tried to invest on a bottom-up program, involving faculty, students, stakeholders, citizens in the challenge of creating and improve content in the Wikimedia ecosystem about the heritage affected by the 2016 seismic series. In this contribution the assumptions, the methodologies and the results of this project are presented, highlighting the laboratory for the editing of the articles on the Museum of Visso and on the Madonna del Voto of Paul from Visso.
title: ФИНАНСИРОВАНИЕ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТИ В РОССИИ: СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ
Creators: name: Смирнов, Алексей
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В условиях научно-технического прогресса эффективность функционирования экономики страны в значительной степени определяется результативностью инновационной деятельности. Осуществление инноваций – это капиталоемкий процесс, требующий значительных финансовых ресурсов. Деньги эти могут быть получены за счет разных источников. Изменение структуры источников финансирования инновационной деятельности Российской Федерации отражает те процессы, которые происходят в национальной экономике и влияют на ее эффективность. Цель настоящего исследования – разработать прогноз объемов финансирования инновационной деятельности в России на основе использования методов математического моделирования с учетом последних изменений в экономике страны. Для достижения данной цели проанализирована динамика объемов финансирования науки из средств федерального бюджета в процентах к общим расходам бюджета и в процентах к валовому внутреннему продукту в 1992-2020 годах, структура и динамика затрат на исследования и разработки по источникам финансирования в 2000-2020 годах; определены факторы, обуславливающие динамику рассматриваемых показателей; конкретизированы возможности и условия использования полученных линейных регрессионных моделей для прогнозирования объемов финансирования инновационной деятельности.
title: The use of contrast enhanced voiding ultrasonography in screening and follow-up of vesicoureteral reflux in pediatric patients: our experience
Creators: name: Skender, Mateja
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Dilatation
subject: Developmental disease
subject: Cystography / Uretrography
subject: Contrast agent-other
subject: Ultrasound
subject: Urinary Tract / Bladder
subject: Ultrasound physics
subject: Contrast agents

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: As contrast-enhanced voiding ultrasonography (CeVUS) is nowadays preformed routinely in radiology practice, and is, moreover, considered the gold standard for the diagnosis of vesicoureteral reflux (VUR), we conducted a retrospective study to...
NFDI4RSE: Fachübergreifende Unterstützung für Forschungssoftware innerhalb der NFDI
Creators: name: Löffler, Frank
Publisher: name: Zenodo
Year: 2020
Subjects: NFDI
RSE
de-RSE

description: Präsentationsfolien der Initiative NFDI4RSE für den Vortrag bei der 2. NFDI-Konferenz am 2020-07-09.
title: Stellungnahme zum Promotionskolleg für angewandte Forschung der Fachhochschulen in Nordrhein-Westfalen
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Promotion
Fachhochschulen
Universitäten
Wissenschaftssystem
Wissenschaftlicher Nachwuchs
Promotionsrecht
Anwendungsorientierung

description: Der Wissenschaftsrat empfiehlt die Verleihung eines eigenständigen Promotionsrechts an das Promotionskolleg für angewandte Forschung der Fachhochschulen in Nordrhein-Westfalen (Promotionskolleg NRW) für eine Probezeit von sieben Jahren. Im Anschluss wird der Wissenschaftsrat eine erneute Begutachtung durchführen. Das Promotionskolleg NRW wurde im Dezember 2020 gegründet und wird von 21 HAW/FH in Nordrhein-Westfalen getragen. Im November 2021 zählte das Promotionskolleg NRW rund 300 promovierende Mitglieder.
Conserved Central Domains Control the Quaternary Structure of Type I and Type II Hsp40 Molecular Chaperones
Creators: name: Fan, Chung-Yang
name: Ramos, Carlos H.I.
name: Oliveira, Cristiano L.P.
name: Torriani, Iris L.
name: Cyr, Douglas M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Hsp40s play an essential role in protein metabolism by regulating the polypeptide binding and release cycle of Hsp70. The Hsp40 family is large and specialized family members direct Hsp70 to perform highly specific tasks. Type I and Type II Hsp40s, such as yeast Ydj1 and Sis1, are homodimers that dictate functions of cytosolic Hsp70, but how they do so is unclear. Type I Hsp40s contain a conserved centrally located Cysteine-rich domain that is replaced by a Glycine and Methionine rich region in Type II Hsp40s, but the mechanism by which these unique domains influence Hsp40 structure and function is unknown. This is the case because high-resolution structures of full-length forms of these Hsp40s have not been solved. To fill this void we built low-resolution models of the quaternary structure of Ydj1 and Sis1 with information obtained from biophysical measurements of protein shape, small angle X-ray scattering and ab initio protein modeling. Low resolution models were also calculated for the chimeric Hsp40s YSY and SYS, in which the central domains of Ydj1 and Sis1 were exchanged. Similar to their human homologs, Ydj1 and Sis1 each has a unique shape with major structural differences apparently being the orientation of the J-domains relative to the long axis of the dimers. Central domain swapping in YSY and SYS correlates with the switched ability of YSY and SYS to perform unique functions of Sis1 and Ydj1, respectively. Models for the mechanism by which the conserved Cysteine-rich domain and Glycine and Methionine rich region confer structural and functional specificity to Type I and Type II Hsp40s are discussed.
Remodeling of the Human Papillomavirus Type 11 Replication Origin into Discrete Nucleoprotein Particles and Looped Structures by the E2 Protein
Creators: name: Ozgur, Sezgin
name: Sim, Jeonggu
name: Griffith, Jack
name: Lin, Biing Yuan
name: Broker, Thomas R.
name: Yu, Jei-Hwa
name: Chow, Louise T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The human papillomavirus (HPV) origin (ori) of DNA replication shares a common theme with many DNA control elements in having multiple binding sites for one or more proteins spaced over several hundred base pairs. The HPV type-11 ori spans 103 bp and contains three palindromic binding sites (E2BS-2, E2BS-3, and E2BS-4) for the dimeric E2 origin binding protein. These sites are separated by 64 bp and 3 bp. E2BS-1 is located 288 bp upstream of E2BS-2 and is not required for efficient transient or cell-free replication. In this study, electron microscopy was used to visualize complexes of HPV-11 ori DNA bound by purified E2 protein. DNA containing only E2BS-2 showed a single E2 dimer bound. DNA containing E2BS-3 and E2BS-4 showed two side-by-side E2 dimers, while DNA containing E2BS-2, E2BS-3, and E2BS-4 exhibited a large disk/ring-shaped protein particle bound indicating that the DNA had been remodeled into a discrete complex, likely containing an E2 hexamer. With all four binding sites present, up to 27% of the DNA molecules were arranged into loops by E2, the majority of which spanned E2BS-1 and one of the other three sites. Studies of the dependence of looping on salt, ATP, and DTT using full length E2 and an E2 protein containing only the carboxyl-terminal DNA binding and protein dimerization domain suggest that looping is dependent on the N terminal domain as well as factors which may affect the manner in which E2 scans DNA for binding sites. The role of these structures in the modeling and regulation of the HPV-11 ori is discussed.
Signal Detection in MIMO Communications System with Non-Gaussian Noises basedon Deep Learning and Maximum Correntropy Criterion
Creators: name: Reza pourmir, Reza Monsefi and Ghosheh Abed Hodtani, Mohammad
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400899
subject: Electrical engineering not elsewhere classified
classificationCode: 400803
subject: Electrical energy generation (incl. renewables, excl. photovoltaics)
classificationCode: 400802
subject: Electrical circuits and systems

description: In this paper, we study signal detection in multi-input-multi output (MIMO) communications system with non-Gaussian noises such as Middleton Class A noise, Gaussian mixtures and alpha stable distributions, using several deep neural network-based detector models such as FULLYCONNECTED and DETNET detector. By applying information theoretic criterion of Maximum Correntropy , SVD analysis on the channel matrix and reducing network complexity, the suggested deep neural network detector performs well in environments with non-Gaussian noises and, compared to the deep neural network-based detector with MSE loss function, achieves better performance
A Terrestrial Planet in a ~1 AU Orbit Around One Member of a ~15 AU Binary
Creators: name: Gould, A.
name: Udalski, A.
name: Shin, I. -G.
name: Porritt, I.
name: Skowron, J.
name: Han, C.
name: Yee, J. C.
name: Kozłowski, S.
name: Choi, J. -Y.
name: Poleski, R.
name: Wyrzykowski, Ł.
name: Ulaczyk, K.
name: Pietrukowicz, P.
name: Mróz, P.
name: Szymański, M. K.
name: Kubiak, M.
name: Soszyński, I.
name: Pietrzyński, G.
name: Gaudi, B. S.
name: Christie, G. W.
name: Drummond, J.
name: McCormick, J.
name: Natusch, T.
name: Ngan, H.
name: Tan, T. -G.
name: Albrow, M.
name: DePoy, D. L.
name: Hwang, K. -H.
name: Jung, Y. K.
name: Lee, C. -U.
name: Park, H.
name: Pogge, R. W.
name: Abe, F.
name: Bennett, D. P.
name: Bond, I. A.
name: Botzler, C. S.
name: Freeman, M.
name: Fukui, A.
name: Fukunaga, D.
name: Itow, Y.
name: Koshimoto, N.
name: Larsen, P.
name: Ling, C. H.
name: Masuda, K.
name: Matsubara, Y.
name: Muraki, Y.
name: Namba, S.
name: Ohnishi, K.
name: Philpott, L.
name: Rattenbury, N. J.
name: Saito, To.
name: Sullivan, D. J.
name: Sumi, T.
name: Suzuki, D.
name: Tristram, P. J.
name: Tsurumi, N.
name: Wada, K.
name: Yamai, N.
name: Yock, P. C. M.
name: Yonehara, A.
name: Shvartzvald, Y.
name: Maoz, D.
name: Kaspi, S.
name: Friedmann, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We detect a cold, terrestrial planet in a binary-star system using gravitational microlensing. The planet has low mass (2 Earth masses) and lies projected at $a_{\perp,ph}$ ~ 0.8 astronomical units (AU) from its host star, similar to the Earth-Sun distance. However, the planet temperature is much lower, T<60 Kelvin, because the host star is only 0.10--0.15 solar masses and therefore more than 400 times less luminous than the Sun. The host is itself orbiting a slightly more massive companion with projected separation $a_{\perp,ch}=$10--15 AU. Straightforward modification of current microlensing search strategies could increase their sensitivity to planets in binary systems. With more detections, such binary-star/planetary systems could place constraints on models of planet formation and evolution. This detection is consistent with such systems being very common.
description: Published in Science, Main and supplementary material combined
title: Stellungnahme zur Institutionellen Akkreditierung der Universidad Paraguayo-Alemana de Ciencias Aplicadas, Asunción (UPA), Paraguay/Heidelberg
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Fachhochschulen
Qualitätssicherung
Hochschulförmigkeit
Private Hochschulen
Akkreditierungszeitraum 5 Jahre
Internationalität

description: Die Universidad Paraguayo-Alemana de Ciencias Aplicadas (UPA) wird vom Wissenschaftsrat unter Auflagen für die Dauer von fünf Jahren akkreditiert. Die UPA ist eine seit 2014 staatlich anerkannte binationale Hochschule mit Sitz in der paraguayischen Hauptstadt Asunción. Sie bietet ihren rd. 300 Studierenden drei Bachelorstudiengänge in den Bereichen Wirtschaft und Ingenieurwesen an.
Prozesse Generativer Visualisierung
Creators: name: Max, Frischknecht
Publisher: name: Zenodo
Year: 2022
Subjects: Generative Design
Data Visualisation
Computer Art

description: Heute nutzen wir, sofern wir mit grösseren Datenmengen arbeiten, meist generative Visualisierungen. Diese haben historisch betrachtet einen objektifizierenden Anspruch auf das Dargestellte. Bei der Visualisierung kultureller Sammlungen ist es jedoch zentral das Dargestellte nicht als objektiv zu begreifen und kritisch zu hinterfragen. Der Beitrag geht deshalb der Frage nach, wie das der Generativen Gestaltung zentrale Prinzip der Iteration genutzt werden kann, um die Objektivität von Visualisierungen zu hinterfragen.
title: Pheochromocytomas: a review of the typical and atypical imaging features with pathologic correlation
Creators: name: Tarmey, Tara
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Endocrine disorders
subject: Education and training
subject: Diagnostic procedure
subject: Nuclear medicine conventional
subject: MR
subject: CT
subject: Abdomen
subject: Retroperitoneum

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the pathogenesis, epidemiology, clinical features and diagnostic pathway of pheochromocytomas. Summarise the typical and atypical pathological and radiological features of pheochromocytomas. Discuss the important differential diagnoses....
Roles of the N- and C-Terminal Domains of Mammalian Mitochondrial Initiation Factor 3 in Protein Biosynthesis
Creators: name: Haque, Md. Emdadul
name: Spremulli, Linda L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Bacterial initiation factor 3 (IF3) is organized into N-domain and C-domains separated by a linker. Mitochondrial IF3 (IF3mt) has a similar domain organization although both domains have extensions not found in the bacterial factors. Constructs of the N- and C-domains of IF3mt with and without the connecting linker were prepared. The Kd’s for the binding of full length IF3mt and its C-domain with and without the linker to mitochondrial 28S subunits are 30, 60 and 95 nM respectively, indicating that much of the ribosome binding interactions are mediated by the C-domain. However, the N-domain binds to 28S subunits with only a 10-fold lower affinity than full length IF3mt. This observation indicates that the N-domain of IF3mt has significant contacts with the protein-rich small subunit of mammalian mitochondrial ribosomes. The linker also plays a role in modulating the interactions between the 28S subunit and the factor; it is not just a physical connector between the two domains. The presence of the two domains and the linker may optimize the overall affinity of IF3mt for the ribosome. These results are in sharp contrast to observations with E. coli IF3. Removal of the N-domain drastically reduces the activity of IF3mt in the dissociation of mitochondrial 55S ribosomes although the C-domain itself retains some activity. This residual activity depends significantly on the linker region. The N-domain alone has no effect on the dissociation of ribosomes. Full-length IF3mt reduces the binding of fMet-tRNA to the 28S subunit in the absence of mRNA. Both the C-terminal extension and the linker are required for this effect. IF3mt promotes the formation of a binary complex between IF2mt and fMet-tRNA that may play an important role in mitochondrial protein synthesis. Both domains play a role promoting the formation of this complex
NFDI4RSE: National Research Data Infrastructure for Scientific Software (Letter of Intent 2020)
Creators: name: Löffler, Frank
name: Busse, Christian E.
name: Nüst, Daniel
name: Druskat, Stephan
name: Hammitzsch, Martin
name: Janosch, Stephan
name: Fritzsch, Bernadette
Publisher: name: Zenodo
Year: 2020
Subjects: NFDI
RSE
de-RSE

description: Non-binding Letter of Intent of the NFDI4RSE initiative for the German National Research Data Infrastructure (NFDI) Program.