cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The germline variants in DNA repair genes in pediatric medulloblastoma
title: a challenge for current therapeutic strategies
titleType: Subtitle
Creators: name: Trubicka, Joanna
name: Zemojtel, Tomasz
name: Hecht, Jochen
name: Falana, Katarzyna
name: Piekutowska-Abramczuk, Dorota
name: Ploski, Rafal
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Medulloblastoma
subject: DNA repair genes
subject: Toxicity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The defects in DNA repair genes are potentially linked to development and response to therapy in medulloblastoma. Therefore the purpose of this study was to establish the spectrum and frequency of germline variants in selected DNA repair genes and their impact on response to chemotherapy in medulloblastoma patients. Methods The following genes were investigated in 102 paediatric patients: MSH2 and RAD50 using targeted gene panel sequencing and NBN variants (p.I171V and p.K219fs*19) by Sanger sequencing. In three patients with presence of rare life-threatening adverse events (AE) and no detected variants in the analyzed genes, whole exome sequencing was performed. Based on combination of molecular and immunohistochemical evaluations tumors were divided into molecular subgroups. Presence of variants was tested for potential association with the occurrence of rare life-threatening AE and other clinical features. Results We have identified altogether six new potentially pathogenic variants in MSH2 (p.A733T and p.V606I), RAD50 (p.R1093*), FANCM (p.L694*), ERCC2 (p.R695C) and EXO1 (p.V738L), in addition to two known NBN variants. Five out of twelve patients with defects in either of MSH2, RAD50 and NBN genes suffered from rare life-threatening AE, more frequently than in control group (p = 0.0005). When all detected variants were taken into account, the majority of patients (8 out of 15) suffered from life- threatening toxicity during chemotherapy. Conclusion Our results, based on the largest systematic study performed in a clinical setting, provide preliminary evidence for a link between defects in DNA repair genes and treatment related toxicity in children with medulloblastoma. The data suggest that patients with DNA repair gene variants could need special vigilance during and after courses of chemotherapy.
L'environnement thérapeutique tel que percu par l'adolescent comme prédicteur de collaboration au traitement.
Creators: name: Lavoie, Gérard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Education, Guidance and Counseling.

description: La resistance au traitement constitue un probleme depuis longtemps reconnu par les intervenants et plusieurs ecrits soulignent la resistance particuliere de l'adolescent. La collaboration etant un facteur essentiel a la demarche therapeutique, la resistance de l'adolescent rend ainsi incertaine l'efficacite du traitement. L'affirmation d'une necessaire collaboration suggere que la mise en place d'un climat favorable a celle-ci constitue un objectif prealable au traitement de l'adolescent. Plusieurs recherches demontrent certes la relation entre la collaboration et la reussite du traitement mais celles-ci ne permettent pas de repondre a la question de ce qui est a meme de susciter cette necessaire collaboration de l'adolescent. Une analyse des ecrits portant sur le probleme de la resistance au traitement a l'adolescence a permis d'identifier un cadre theorique pertinent a l'operationnalisation de la presente recherche. En effet, la resistance de l'adolescent etant consideree comme resultant de la relation entre le contexte de traitement et l'adolescent en maturation, la theorie relationnelle de la motivation etait donc appropriee pour fonder et guider notre demarche. Selon cette theorie, la resistance ou la motivation que l'adolescent manifeste renvoie a ses perceptions presentes et situationnelles relatives au milieu de traitement. Pour etre motivant, ce milieu doit de plus s'accorder a la realite maturationnelle de l'adolescence et repondre aux preferences de l'adolescent en matiere de traitement. Les resultats obtenus soutiennent notre hypothese generale a l'effet que la collaboration de l'adolescent refere aux perceptions de ce dernier relatives au contexte de traitement. Ils permettent de plus d'identifier une configuration de facteurs particulierement favorable a la collaboration de l'adolescent. Afin de maximiser celle-ci, le milieu doit permettre a l'adolescent d'experimenter son autonomie dans le cadre de limites clairement affirmees, et ce dans une atmosphere de support. Au debut de la demarche, l'orientation visant la resolution des problemes d'ordre pratique de l'adolescent peut etre introduite alors que celle visant la resolution de ses problemes personnels profite de l'etablissement prealable d'un contexte relationnel de qualite.
The changing and hybridising concept of home in the space and architecture of Bangkok from the 19th century to the present
Creators: name: Prapapyuenyong, Teerapatt
Publisher: name: Swinburne
Year: 2024

description: Studying the changing and hybridising Thai concept of home at the conceptual level of space and architecture in Bangkok following the modernisation policies and processes of Rama IV (r. 1851-1868) with the peaks of Rama V (r. 1868-1910) and IX (r. 1946-2016), and the short-lived reign of The People’s Party (1930-1946) provides an alternative view of how the Thai identity of Bangkok has been shaped and reshaped with the hybridisation between the Western influences and local culture from the 1850s to present.
РОЛЬ ИНТЕРНЕТА В РАЗВИТИИ СОВРЕМЕННОЙ МОЛОДЕЖИ
Creators: name: Данилова Наталья Ильинична
Publisher: name: Медиасреда
Year: 2020
Subjects: социальные сети
молодежь
интернет-пространство
информационные технологии
публичные форумы
виртуальные сообщества
коммуникации
коммуникационные барьеры.

description: В статье раскрыты возможности общества с возникновением и развитием Интернета: на этапе появления, а также на этапе активного развития и современного состояния. Обращается внимание на то, что Интернет за последнее время создал благоприятную среду практически для всех направлений жизни общества, особенно для молодого поколения. Раскрываются особенности использования Интернета для достижения самых различных целей. Рассмотрены отрицательные черты влияния Интернета на молодое поколение.
МЕДИАОТРАЖЕНИЕ ТЕМЫ ФЕМИНИЗМА В ОТЕЧЕСТВЕННЫХ ОБЩЕСТВЕННО-ПОЛИТИЧЕСКИХ ИНТЕРНЕТ-СМИ
Creators: name: Клец Юлия Александровна
name: Ермолова Анастасия Константиновна
Publisher: name: Медиасреда
Year: 2020
Subjects: феминизм
общественно-политические интернет-СМИ.

description: Статья посвящена жанрово-тематической специфике медиаотражения такого актуального явления современности, как феминизм в отечественных общественно-политических интернет-СМИ, приведены количественные данные по публикациям на тему феминизма в исследуемых интернет-СМИ. В частности, в данной статье рассматривается жанровая палитра текстов о феминизме и приводятся результаты контент-анализа тематики публикаций, что позволяет говорить об определенной специфике преподнесения данной темы в СМИ.
Cancer incidence patterns among Chinese immigrant populations in Alberta.
Creators: name: Luo, Wei.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Biostatistics.

description: Objectives. To examine the incidence of cancer among Chinese immigrants in Alberta and compare these rates to those of Canadian-born Alberta residents as well as to the Chinese in China. Methods. Cancer cases among Chinese immigrants and Canadian-born Alberta residents were identified from the Alberta Cancer Registry (1974-1993). Statistics Canada provided population counts by age group, sex, and birthplace for Alberta residents for each of the census years (1971, 1981, 1986, and 1991). Direct age-standardized incidence rates (ASIRs) were calculated using the 'world population' as standard. ASIRs for Chinese in China were acquired from 'Cancer Incidence in Five Continents', Vol IV-VII. Descriptive analysis and Poisson regression modeling were employed to obtain the rate ratios for certain cancer sites among the three populations. Age-period-cohort analysis was used to examine the secular effect on cancer development of certain cancer sites. Results. Chinese immigrants had lower ASIRs for all cancer (excl. 173) than Canadian-born Alberta residents and Chinese in China for both males and females. Chinese immigrants had significantly higher ASIRs for liver, stomach, esophagus, and kidney cancers than the Canadian-born population but lower than Chinese in China. Chinese immigrants had significantly lower ASIRs for breast and prostate cancer than the Canadian-born population but higher than Chinese in China. Conclusions. First generation migrants' risk for overall cancer incidence was intermediate between that for Chinese in China and Canadian-born populations. There also appeared to be transition in risk towards the Canadian-born pattern for liver, colon, stomach. These findings are generally in line with those from other studies of this kind and extend the work on cancer mortality rates in Chinese migrants in Ontario by Hanley.
On the Laguerre series expansion and transform.
Creators: name: Quednau, Stephan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Electronics and Electrical.

description: The Laguerre transform is defined and motivated based on the Laguerre series expansion and Laguerre filter. The Laguerre transform is represented by a unitary transformation matrix of infinite size and is controlled by the Laguerre parameter. When realised as a finite size matrix, the case where the Laguerre parameter approaches zero results in the identity matrix. Otherwise the transform is less and less unitary and the inverse transform is not complete. However, we can choose the size of the matrix such that orthogonality is preserved and use the matrix transform for signal compression. We show that modeling an acoustic duct impulse response using the Laguerre transform has less mean-squared error than the truncated DCT transform for high compression ratios. We also show results using least-square solutions and adaptive filtering where the Laguerre filter gave improved results over classical methods.
Intentional injury among the indigenous and total populations in British Columbia, Canada: trends over time and ecological analyses of risk
Creators: name: George, M. Anne
name: Jin, Andrew
name: Brussoni, Mariana
name: Lalonde, Christopher E.
name: McCormick, Rod
Publisher: name: BioMed Central
Year: 2017

description: Background: Our objective was to explore intentional injury disparity between Indigenous populations and the total population in the province of British Columbia (BC), Canada. We focus on hospitalizations, including both self-inflicted injuries and injuries inflicted by others. Methods: We used data from BC’s universal health care insurance plan, 1991 to 2010, linked to Vital Statistics databases. Indigenous people were identified through the insurance premium group, and birth and death records. Place of residence was identified through postal code. We calculated crude hospitalization incidence rates and the Standardized Relative Risk (SRR) of hospitalization, standardized by gender, 5-year age group, and Health Service Delivery Area (HSDA). With HSDA populations as the units of observation, linear regression was used to test hypothesized associations of Indigenous ethnicity, geographic, and socio-economic characteristics with SRR of injury. Results: During the period 1991–2010, the crude rate of hospitalization for intentional injuries was 8.4 per 10,000 person-years (95% confidence interval (CI): 8.3 to 8.5) for the total BC population, compared to 45.3 per 10,000 (95% CI: 44.5 to 46.1) for the Indigenous population. For both populations, risk declined over the period for injuries self-inflicted and inflicted by others. The linear regression model predicts that the off-reserve Indigenous population will have SRR of intentional injury 3.98 greater, and the on-reserve Indigenous population 4.17, greater than the total population. The final model was an excellent fit (R2 = 0.912, F = 177.632, p < 0.001), and found that three variables - occupational risk, high school diploma, and university degree – each provide independent effects when interacting multiplicatively with Indigenous ethnicity. Conclusions: The observation of substantially declining rates of intentional injury for both the Indigenous and total BC populations is off-set by the high disparity in risk between the two populations, which will likely continue until Canada reduces disparity with respect to discriminatory practices, and physical, social, and economic conditions.
Integrated Pest Management, 2021 Quarter 4 Newsletter
Creators: name: Washington State University Extension
Publisher: name: Washington State University
Year: 2021

description: Highlights include:
description: Indoor storage, mite control to protect bees
description: Winter resources for small grain growers
description: Enhanced IPM in potatoes
description: Grape grower resources
description: Biodegradable mulch in organic veggies
description: Sustainability training for landscape pros
description: Preventive IPM tactics for small farms
description: Biological and mechanical control in tree fruits
description: IPM outreach to mint and grape growers
РОЛЬ СРЕДСТВ МАССОВОЙ ИНФОРМАЦИИ В ПРОФИЛАКТИКЕ ПРЕСТУПЛЕНИЙ ТЕРРОРИСТИЧЕСКОГО ХАРАКТЕРА
Creators: name: Катькало Алена Олеговна
Publisher: name: Медиасреда
Year: 2020
Subjects: терроризм
средства массовой информации
правонарушение
распространение информации
правовоспитательная деятельность.

description: Автор рассматривает роль органов государственной власти и средств массовой информации в профилактике террористических и экстремистских преступлений, указывает на инструменты в борьбе против данных видов правонарушений. В статье автор предлагает рассмотреть возможность создания специальных телевизионных программ и выпусков на радио, посвященных распространению через социальные сети информации террористического характера, проведение совместных встреч органов государственной власти и представителей журналистского сообщества с различными молодежными группами.
ФУНКЦИОНИРОВАНИЕ В МЕДИАДИСКУРСЕ СОЧЕТАНИЯ «РЕТРОГРАДНЫЙ МЕРКУРИЙ» КАК КЛЮЧЕВОГО СЛОВА ТЕКУЩЕГО МОМЕНТА
Creators: name: Кудрявцева Валерия Константиновна
Publisher: name: Медиасреда
Year: 2020
Subjects: медиадискурс
медиасреда
ключевое слово текущего момента

description: В данном исследовании рассматривается проблема трансформации ключевых слов текущего момента под влиянием взаимодействия акторов социальной коммуникации внутри медиадискурса. В ходе исследования было проанализировано, как ключевое слово «ретроградный Меркурий» изменяется при использовании в отечественных СМИ и социальных сетях. Отмечено, что ключевое слово приобрело несколько коннотативных значений,вытеснивших узуальное из медиасреды.
title: Modeling Highly Buoyant Flows in the Castel Giorgio
title: Torre Alfina Deep Geothermal Reservoir
titleType: Subtitle
Creators: name: Volpi, Giorgio
name: Magri, Fabien
name: Colucci, Francesca
name: Fisher, Thomas
name: De Caro, Mattia
name: Crosta, Giovanni B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The Castel Giorgio-Torre Alfina (CG-TA, central Italy) is a geothermal reservoir whose fluids are hosted in a carbonate formation at temperatures ranging between 120°C and 210°C. Data from deep wells suggest the existence of convective flow. We present the 3D numerical model of the CG-TA to simulate the undisturbed natural geothermal field and investigate the impacts of the exploitation process. The open source finite-element code OpenGeoSys is applied to solve the coupled systems of partial differential equations. The commercial software FEFLOW® is also used as additional numerical constraint. Calculated pressure and temperature have been calibrated against data from geothermal wells. The flow field displays multicellular convective patterns that cover the entire geothermal reservoir. The resulting thermal plumes protrude vertically over 3 km at Darcy velocity of about m/s. The analysis of the exploitation process demonstrated the sustainability of a geothermal doublet for the development of a 5 MW pilot plant. The buoyant circulation within the geothermal system allows the reservoir to sustain a 50-year production at a flow rate of 1050 t/h. The distance of 2 km, between the production and reinjection wells, is sufficient to prevent any thermal breakthrough within the estimated operational lifetime. OGS and FELFOW results are qualitatively very similar with differences in peak velocities and temperatures. The case study provides valuable guidelines for future exploitation of the CG-TA deep geothermal reservoir.
Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
Creators: name: Edemann-Callesen, Henriette
name: Habelt, Bettina
name: Wieske, Franziska
name: Jackson, Mark
name: Khadka, Niranjan
name: Mattei, Daniele
name: Bernhardt, Nadine
name: Heinz, Andreas
name: Liebetanz, David
name: Bikson, Marom
name: Padberg, Frank
name: Hadar, Ravit
name: Nitsche, Michael A.
name: Winter, Christine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Neuroscience
subject: Psychiatric disorders
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS.
title: Potential Predictors of Plasma Fibroblast Growth Factor 23 Concentrations
title: Cross-Sectional Analysis in the EPIC-Germany Study
titleType: Subtitle
Creators: name: Giuseppe, Romina Di
name: Kühn, Tilman
name: Hirche, Frank
name: Buijsse, Brian
name: Dierkes, Jutta
name: Fritsche, Andreas
name: Kaaks, Rudolf
name: Boeing, Heiner
name: Stangl, Gabriele I.
name: Weikert, Cornelia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. However, what determines higher FGF23 levels is still unclear. Also, little is known about the influence of diet on FGF23. The aim of this study was therefore to identify demographic, clinical and dietary correlates of high FGF23 concentrations in the general population. Methods We performed a cross- sectional analysis within a randomly selected subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany comprising 2134 middle-aged men and women. The Human FGF23 (C-Terminal) ELISA kit was used to measure FGF23 in citrate plasma. Dietary data were obtained at baseline via validated food frequency questionnaires including up to 148 food items. Results Multivariable adjusted logistic regression showed that men had a 66% lower and smokers a 64% higher probability of having higher FGF23 (≥ 90 RU/mL) levels compared, respectively, with women and nonsmokers. Each doubling in parathyroid hormone, creatinine, and C-reactive protein was related to higher FGF23. Among the dietary factors, each doubling in calcium and total energy intake was related, respectively, to a 1.75 and to a 4.41 fold increased probability of having higher FGF23. Finally, each doubling in the intake of iron was related to an 82% lower probability of having higher FGF23 levels. Results did not substantially change after exclusion of participants with lower kidney function. Conclusions In middle-aged men and women traditional and non-traditional CVD risk factors were related to higher FGF23 concentrations. These findings may contribute to the understanding of the potential mechanisms linking increased FGF23 to increased CVD risk.
Rewire
Creators: name: Dexter, Braden Royce
Publisher: name: University of Iowa
Year: 2024
Subjects: Audio
Electronics
Interactive
Slide Film
Photography
Sculpture

description: My work combines visual aesthetics, sound, and technology to portray the unpredictable and decaying systems that make up our emotional and physical environments. I use meaningful identification and synchronicity as a lens to question our memory as a reliable narrator. I intend to invoke thought on memory and convey the cyclical emotions of wonder, peace, hopelessness, and loss that continue to be forgotten. Each piece of this body of work is connected or controlled, firing and responding like synapses in the brain to create thoughts and memories that represent who we are.
description: In the spring of 2021, I was given a box of 35mm slide film and a beat-up slide projector. I dusted off the projector and found hundreds of images, taken by people I did not know. I was fascinated by the beautiful color and texture found on the images. The scratches, marks and degradation represented decades of aging, carousels of memories that no longer belonged to those who experienced and created them.
description: In my work I want to represent these “lost” slides and other discarded technologies to emphasize their beauty, but also the fleeting nature and unreliability of our memories. I work with older technology by modifying pieces with modern microcontrollers to represent a system of control that connects one thought to another. My goal is to embrace the beautiful and quirky qualities of forgotten technology to create interesting compositions of space, light, and sound.
Functional analysis of LAP2 beta, gamma and o during the development of zebrafish (Danio rerio)
Creators: name: Beauvais, Ariane
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Cell.

description: Three isoforms of the lamina-associated polypeptide 2 (LAP2) family, have been identified in zebrafish (Danio rerio). Zebrafish LAP2 (ZLAP2) beta, gamma and o have identical aminoterminal regions containing the LEM domain. A lamina binding domain and a membrane spanning sequence are also present in the carboxyterminal region. The maternally synthesized ZLAP2o is the biggest of the three isoforms and is detected as a polypeptide of Mr 84 000. The somatic isoforms, ZLAP2beta and gamma are represented as smaller polypeptides of Mr 66 000 and 45 000 respectively. Western and northern blot analysis indicated that ZLAP2o is the only LAP2 present in early embryonic stages up to the gastrula stage. With the progression of embryonic development, the amount of ZLAP2o decreased whereas the amount of somatic isoforms ZLAP2beta and gamma) increased. Using immunofluorescence on somatic cells, ZLAP2beta and gamma are observed at the nuclear periphery in interphase cells. A cytoplasmic distribution appeared in late prometaphase and the isoforms are located at the surface of segregated chromosomes in late anaphase. However, during early embryonic development, ZLAP2o is associated with mitotic chromosomes prior to anaphase and the formation of karyomere is also observed. Using the morpholino technology, knock-down experiments on ZLAP2 during the zebrafish development suggest a strong correlation between the loss of ZLAP2 expression and abnormal phenotypes observed 24 hours post-fertilization. Altogether, my data indicate that ZLAP2 proteins may play a key role in early developmental events.
Development and validation of smart insoles for gait monitoring of diabetic patients
Creators: name: Tan, Adin
Publisher: name: Swinburne
Year: 2024

description: The aim of this project was to develop low-cost, high-resolution pressure sensing insoles for gait monitoring. Properties of flexible piezoelectric pressure sensors were investigated in detail and several iterations of screen-printed insoles were produced. A new material property, electrical viscosity, was discovered and an industrial standard proposed. A novel validation method was developed to ensure the accuracy of the insoles. The insoles were used for a healthy volunteer study, which involved 20 participants and a clinical trial comprising of 14 diabetic patients. Novel gait indices, which measured gait symmetry, laterality and consistency, were developed from the experimental data.
"Moments of being" Elizabeth Dalloway: A study of Virginia Woolf's daughter figures.
Creators: name: McNeil, Andrea F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Literature, English.

description: This thesis traces the trajectory of a number of Virginia Woolf's daughter figures in their struggle to achieve selfhood. The four chapters of this project thus examine Woolf's early daughter figures, Phyllis and Rosamond, title characters of a 1906 work of short fiction; Rachel Vinrace, the heroine of the 1915 novel The Voyage Out; Elizabeth Dalloway, the daughter of the central figure of Woolf's 1925 novel, Mrs Dalloway, and, finally, the various daughter figures of the 1937 novel, The Years: Eleanor, Delia and Rose Pargiter, Kitty Malone, and Peggy Pargiter. The thesis is structured around my close readings of these texts, and is informed by psychoanalytic and feminist theory. The central focus of this project is a study of Elizabeth Dalloway, who I read as Woolf's pre-eminent daughter figure, as this character alone transcends the fixed gender roles which limit each of the other daughter figures studied in this project. I look to Woolf's concept of "moments of being" to explain this character's vision of a future outside of the marriage plot and domestic existence in which her fictional predecessors and successors are inescapably inscribed. My examination of the motifs that recur in each of the texts, particularly images of silence and self-abnegation and of the strained mother-daughter relationship, allows me to analyse the author's revision of the developmental stories of her daughter figures over the course of her career. Moreover, Virginia Woolf's narrative strategies, most particularly the question of closure in Mrs Dalloway, as well as the representation of female characters who defy the standards of conventional femininity, provide insight into Elizabeth Dalloway's position as a figure of affirmation, emancipation and potentiality.
title: Definitely maybe
title: can unconscious processes perform the same functions as conscious processes?
titleType: Subtitle
Creators: name: Hesselmann, Guido
name: Moors, Pieter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: consciousness
subject: social psychology
subject: cognitive psychology
subject: visual perception
subject: continuous flash suppression
subject: 100 Philosophie und Psychologie::150 Psychologie

description: Hassin recently proposed the “Yes It Can” (YIC) principle to describe the division of labor between conscious and unconscious processes in human cognition. According to this principle, unconscious processes can carry out every fundamental high-level cognitive function that conscious processes can perform. In our commentary, we argue that the author presents an overly idealized review of the literature in support of the YIC principle. Furthermore, we point out that the dissimilar trends observed in social and cognitive psychology, with respect to published evidence of strong unconscious effects, can better be explained by the way how awareness is defined and measured in both research fields. Finally, we show that the experimental paradigm chosen by Hassin to rule out remaining objections against the YIC principle is unsuited to verify the new default notion that all high-level cognitive functions can unfold unconsciously.
The renaissance of impasse in American/Quebec literary relations: Comparative readings of Carlyle, Emerson, Melville, Aquin, Ducharme and Beaulieu.
Creators: name: Leroux, Jean-François.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Literature, Comparative.

description: This study comprises a series of comparative readings of authors key to the high-cultural renaissances in the Romantic literature of nineteenth-century America and twentieth-century Quebec. The Introduction lays out the historical and theoretical foundation for such a cross-cultural, cross-temporal reading, by arguing that, on the basis of both intellectual/historical "influence" and a strong affinity of means and ends, the American Romantic canon should reasonably be extended to include Quebec writers from the 1960s. The comparative readings at issue thus approach the writers under scrutiny from the converging perspectives of literary history (as artists sharing in an intellectual tradition) and literary theory (as moderns or contemporaries similarly participating in a bid for "authority"). In the first instance, from the perspective of literary history, the assimilation of the highly representative thought and rhetorical practice of sixteenth-century French skeptic Michel de Montaigne into the mainstream of American Romanticism by such equally representative authors as Ralph Waldo Emerson and Herman Melville serves to suggest an explanation for the proximity of their ideas and aims with those of their twentieth-century Quebec counterparts. In the second, a survey of criticism on works from both periods complements that account by showing how such a complex body of criticism-it too enabled by a body of theory with verifiable affinities with the thought of Montaigne-tends to (re)duplicate the rhetorical practice of American and Quebec writers under scrutiny by finding in writers or critics from the opposite canon a call to autonomy, and thereby effectively assimilating them to their own enterprise. Chapter One attempts to track the presence of Montaigne's philosophic skepticism at the center of the revolutionary poetics, prophecy, and politics of Thomas Carlyle, whose work is construed as basic to an understanding of the relationships between philosophical and political revolutions in the (post)Romantic era. Building on the first chapter, the second approaches Emerson, not in the tradition of prophecy and ethical direction with which he is conventionally associated, but from the standpoint of the (Post)Romantic and Existentialist enterprise of (re)visionary mythmaking in which he played such a significant role. Chapter Three concludes the thesis by bringing together the various dimensions of the problem engaged in Chapters One and Two, by a reading of Melville in relation to his devoted Quebec reader and student Beaulieu. (Abstract shortened by UMI.)
Speaking Through Identity: Israeli-American Language Negotiation in the Home
Creators: name: Hartman, Shira
Publisher: name: Brandeis University
Year: 2023
Subjects: Jewish Camps
Language Development
Modern Hebrew Language
Modern Hebrew Literature
School Education
Bilingual education
Home Education

description: In this thesis, I am focusing on finding patterns in how parents present Modern Hebrew to their children. There are two groups presented in this thesis: secular Israeli Americans in the Boston area (including Israelis who have immigrated from Israel to the United States and children of these immigrant parents) and secular Jewish Americans in the Boston area (families that are second-generation in the United States; their grandparents immigrated from Europe to the United States). I conducted this research by interviewing 12 individual parents, seven Israeli American parents, and five American Jewish parents; this data set is small and not representative of Jewish Americans and Israeli Americans in the United States, but it is a good starting point to start thinking about different strategies in the future. I have asked them an array of questions, such as how they passed Hebrew to their children, whether they send their children to any Hebrew/Jewish programs or institutions, and how did Hebrew play a part in their households. This thesis examines how, from my 12 interviews, there seems to be a similar starting point, but the two groups learn the language differently; Jewish Americans and Israelis, based on my research, share a starting point regarding the reasoning behind learning Hebrew, for example in Jewish ceremonies such as Bar/Bat Mitzvahs and Jewish holidays. Moreover, the two groups take on the understanding of literacy in different ways. Two main points that were discovered by the interviews were: 1. Siblings will talk to each other in the opposite language depending on what the parents speak to them, and 2. During my interviews, although I did not ask questions about the Holocaust, two families linked their desire to learn Hebrew to their family’s association with the Holocaust. This is important to research and figure out a trend between the two groups because this work will help educators understand where these similarities start and interweave with one another. Ultimately, the goal of this thesis is to demonstrate how Hebrew identity inside the household can help create a cultural bridge between Israeli Americans and Jewish Americans which is important because these two groups need Hebrew as their foundation to understand each other.
title: Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease (CAPTURE PD)
title: Protocol for a Multicenter Study
titleType: Subtitle
Creators: name: Siepmann, Timo
name: Pinter, Alexandra
name: Buchmann, Sylvia J.
name: Stibal, Leonie
name: Arndt, Martin
name: Kubasch, Anne Sophie
name: Lipp, Axel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: autonomic
subject: Parkinson’s disease
subject: diagnosis
subject: pilomotor
subject: axon-reflex
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: In Parkinson’s disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function via quantitative direct and indirect test of sudomotor function. Methods/design: A prospective controlled study will be conducted at four study sites in Europe and the USA. Fifty-two male and female patients with idiopathic PD (Hoehn and Yahr 1–2) and 52 age- and sex-matched healthy controls will be recruited. Axon-reflex-mediated pilomotor erection will be induced by iontophoresis of phenylephrine on the dorsal forearm. Silicone impressions of the response will be obtained, scanned, and quantified for pilomotor muscle impressions by number, impression size, and area of axon-reflex spread. Axon-reflex-mediated sweating following acetylcholine iontophoresis will be quantified for number and size of droplets and axon-reflex spread. Sympathetic skin responses, autonomic and motor symptoms will be evaluated. Tests will be performed at baseline, after 2 weeks, 1, 2, and 3 years. Skin biopsies will be obtained at baseline and after 3 years and will be analyzed for nerve fiber density and alpha-synuclein accumulation. Discussion: We anticipate that progression of autonomic nerve dysfunction assessed via pilomotor and sudomotor axon-reflex tests is related to progression of autonomic symptom severity and alpha- synuclein deposition. Potential applications of the techniques include interventional studies evaluating disease-modifying approaches and clinical assessment of autonomic dysfunction in patients with PD. Clinical trail registration: TRN NCT03043768.
An efficient deadline-constrained and data locality aware dynamic scheduling framework for multi-tenancy clouds
Creators: name: Jia, Ru
Publisher: name: Swinburne
Year: 2024

description: This research investigates scheduling and resource allocation strategies for multi-tenant cloud applications and their support platforms. This novel research, from both cloud providers’ and tenants’ perspectives, investigates key issues on how to provide efficient scheduling policies while also meeting QoS requirements, improving system’s throughput and resource utilisation, achieving better data locality, and reducing job completion time. This work proposes a novel fairer resource allocation, a data locality aware scheduler and a deadline constrained job scheduler to meet jobs’ deadlines, and finally proposes a scheduling framework, which comprises each of the above individual plug-in schedulers used in tandem.
The Canadian Football League: Radically Canadian?
Creators: name: Cantelon, Michael.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Canadian Studies.

description: Sport can be a medium for inculcating national passions and also as an outlet for the transmission of these. Indeed, Canadian professional football has made such claims for its game. The Canadian Football League (CFL) uses marketing slogans like "The Canadian Football League: RADICALLY CANADIAN" and "Our Balls are Bigger" in attempts to attract fans and sell CFL merchandise. The League touts itself as being the only truly Canadian professional sports league and describes its championship game, the Grey Cup, as a national unifying event. In order to answer the general question: How Canadian is the CFL, the study examines the following specific questions: what are the Canadian specificities of the game?, who controls the game?, who plays the game?, how is the game portrayed? Contrary to its rhetoric, the Canadian Football League is a misnomer. The CFL seizes upon the nationalistic passions of the fan base to further its growth while marginalizing the participation of the Canadian player. In fact, the CFL is Canadian in rules only and has, throughout its history, been subject to relentless forces of Americanisation. Using empirical quantitative data for the CFL from 1990--2000 as well as qualitative data throughout the CFL's history, the study demonstrates the diverse ways in which these forces manifest themselves.
Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation
Creators: name: Gualdoni, Guido A.
name: Lingscheid, Tilman
name: Schmetterer, Klaus G.
name: Hennig, Annika
name: Steinberger, Peter
name: Zlabinger, Gerhard J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Cytokines
subject: Innate immunity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Deregulation of inflammasome activation was recently identified to be involved in the pathogenesis of various inflammatory diseases. Although macrolide antibiotics display well described immunomodulatory properties, presumably involved in their clinical effects, their impact on inflammasome activation has not been investigated. We compared the influence of macrolides on cytokine induction in human monocytes. The role of intracellular azithromycin- accumulation was examined by interference with Ca++-dependent uptake. We have also analysed the signalling cascades involved in inflammasome activation, and substantiated the findings in a murine sepsis model. Azithromycin, but not clarithromycin or roxithromycin, specifically inhibited IL-1α and IL-1β secretion upon LPS stimulation. Interference with Ca++-dependent uptake abolished the cytokine-modulatory effect, suggesting a role of intracellular azithromycin accumulation in the modulatory role of this macrolide. Azithromycin’s inhibiting effects were observed upon LPS, but not upon flagellin, stimulation. Consistent with this observation, we found impaired induction of the LPS-sensing caspase-4 whereas NF-κB signalling was unaffected. Furthermore, azithromycin specifically affected IL-1β levels in a murine endotoxin sepsis model. We provide the first evidence of a differential impact of macrolides on the inflammasome/IL-1β axis, which may be of relevance in inflammasome-driven diseases such as chronic obstructive pulmonary disease or asthma.
Time domain computer simulation and its applications to transient EMC problems and VLSI interconnection systems.
Creators: name: Cai, Xiao-Ding.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Electronics and Electrical.

description: The time domain computer simulation presented in this Ph.D. thesis is composed of three parts. The first part is an introduction of a novel finite element formulation in the Laplace domain and its applications to the technical area of electromagnetic compatibility (EMC). The second part presents a new time domain resistance (skin effect) model and its applications to the analysis of VLSI interconnection systems. The applications include two topics: time domain analysis of lossy VLSI interconnects with a time domain skin effect model; and time domain analysis of interconnect discontinuities. In the last part of this thesis, a numerical modelling approach of the partial inductance, which is of great importance in ground noise problems, is provided. All the analysis models in this thesis are finalized in the time domain, though some of them start in the Laplace domain or space domain. Original contributions are summarized in Section 1.3.
The Promise and Failure of the Zionist-Maronite Alliance, 1920-1948
Creators: name: Abramson, Scott
Publisher: name: Brandeis University
Year: 2012

description: Much of the historiography on the intercourse between Palestinian Jews and Lebanese Maronites concerns only the two peoples’ relations in the seventies and eighties. This thesis, in contrast, attempts a departure from this scholarship, joining the handful of other works that chart the history of the Zionist-Maronite relationship in its earliest incarnation. From its inception to its abeyance beginning in 1948, this almost thirty-year relationship was marked by a search of a formal alliance. This thesis, by presenting a panoptical survey of early Zionist-Maronite relations, explores the many dimensions of this pursuit. It details the Zionists and Maronites’ numerous commonalities that made an alliance desirable and apparently possible; it profiles the specific elements among the Zionists and Maronites who sought an entente; it examines each of the measures the two peoples took to this end; and it analyzes why this protracted pursuit ultimately failed. The study concludes that the liabilities of a formal association with the Zionists in the Middle East and “Arabist” developments in Lebanon beginning in the early forties conspired to prevent the Zionists and Maronites’ friendship from graduating to a formal alliance.
Effect of selected ankle supports on resistance to inversion force and range of motion.
Creators: name: Cronin, Alison.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Recreation.

description: The purpose of this study was to determine if the ankle supports chosen were able to provide increased resistance to inversion, as measured by moment of force, without limiting plantar flexion or dorsiflexion. Resistance to inversion moment of force was measured on an isokinetic dynamometer (KinCom) in passive mode, for six support conditions (low-top (LT) and midcut (MC) shoes with semi-rigid and flexible orthoses). The braces used were the Active Ankle T1 Trainer (AA) and the Ankle Stabilizing Orthosis (ASO). The shoes were ASICS Gel Airier volleyball shoes in low-top and midcut models. It was found that there was a significant difference in resistance to inversion moment of force mean, between the MC alone and the LT with AA. It was concluded that the best support condition was the combination of LT and AA. It decreased sagittal range of motion the least and provided increased force to resist inversion as compared to the control condition (LT). (Abstract shortened by UMI.)
To what extent are psychiatrists aware of the comorbid somatic illnesses of their patients with serious mental illnesses? – a cross-sectional secondary data analysis
Creators: name: Dornquast, Christina
name: Tomzik, Juliane
name: Reinhold, Thomas
name: Walle, Matthias
name: Moenter, Norbert
name: Berghoefer, Anne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Mental disorders
subject: Somatic comorbidity
subject: Secondary data analysis
subject: Claims data
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Somatic comorbidities are a serious problem in patients with severe mental illnesses. These comorbidities often remain undiagnosed for a long time. In Germany, physicians are not allowed to access patients’ health insurance data and do not have routine access to documentation from other providers of health care. Against this background, the objective of this article was to investigate psychiatrists’ knowledge of relevant somatic comorbidities in their patients with severe mental illnesses. Methods Cross- sectional secondary data analysis was performed using primary data from a prospective study evaluating a model of integrated care of patients with serious mental illnesses. The primary data were linked with claims data from health insurers. Patients’ diagnoses were derived on the basis of the ICD-10 and the Anatomical Therapeutic Chemical (ATC) classification system. Diabetes, hypertension, coronary artery disease (CAD), hyperlipidaemia, glaucoma, osteoporosis, polyarthritis and chronic obstructive pulmonary disease (COPD) were selected for evaluation. We compared the number of diagnoses reported in the psychiatrists’ clinical report forms with those in the health insurance data. Results The study evaluated records from 1,195 patients with severe mental illnesses. The frequency of documentation of hypertension ranged from 21% in claims data to 4% in psychiatrists’ documentation, for COPD from 12 to 0%, respectively, and for diabetes from 7 to 2%, respectively. The percentage of diagnoses deduced from claims data but not documented by psychiatrists ranged from 68% for diabetes and 83% for hypertension, to 90% for CAD to 98% for COPD. Conclusions The majority of psychiatrists participating in the integrated care programme were insufficiently aware of the somatic comorbidities of their patients. We support allowing physicians to access patients’ entire medical records to increase their knowledge of patients’ medical histories and, consequently, to increase the safety and quality of care.