AntibiogramofBacterialisolatesobtainedfromInfantsandChildrenattheUniversityofCalabarTeachingHospital(UCTH)..pdf
Creators: name: Ugwu, Joy Chinweokwu
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320701
subject: Medical bacteriology
classificationCode: 320702
subject: Medical infection agents (incl. prions)

description: The gradual increase in antimicrobial resistance antibiotics is on the rise and babies are in children is a major challenge in the field of particularly at increased risk because of lower hospit a l epidemiology and medi c a l immunity. The study recommends the need for microbiology. This study was conducted to the development of alternative therapy. investigate the susceptibility pattern of commonly used antimicrobial agents against Keywords: Infection, Bacterial isolates, bacterial isolates in children attending UCTH. Neonates, Antibacterial, Resistance, Sensitive Fifty clinical specimens; blood, urine, eye, ear and wound swap were collected from infants and Introduction children 1-day old to 9 years. About 2mL of the Over the last decade, programs targeting specific blood was dispensed into Brain Heart infusion childhood illness such as diarrhea and acute broth (10ml) contained in a Bijou bottle and respiratory tract infections along with higher 0 incubated for 2 days at 37 C. Midstream urine immunization coverage and bettermanagement of samples were collected into sterile universal illness in children have contributed to significant containers and cultured on blood and CLED agar decline in infant mortality rates in many using the Leigh and Williams paper strip method, developing countries. However, one of the major while sterile swab-stick was used to collect ear challengesin the field of hospital epidemiology is and eye specimen (discharge). The ear the continuousincrease in antimicrobialresistance specimens were cultured on CLED and blood (Lagunju etal.,2008;Akingbadetal.,2013). agar while the eye swap on CLED and chocolate agar. Isolates susceptibility was tested on Therapy of infectious diseases caused by gentamicin, erythromycin, Zithromax, bacteria resistance to multiple antimicrobial ampicillin, amoxicillin and penicillin using disc agents had emerged as one of the greatest diffusion method by Kirby-Bauer. Of the 50 challenges facing clinicians. Problems created subjects examined, a total of 39 bacterial isolates by antibiotic resistance have profound effects were obtained from the 36(72%) culture positive upon the practice of Paediatrics resulting in a samples. S. aureus was the most isolated continuing need for revision of recommended 22(56.4%), followed by P. aeruginosa 7(17.9%), therapies of common infections. Every year, an Streptococci, Coliform, and Proteus were estimated 30 million newborns acquire a 3(7.7%), 6(15.4%) and 1(2.6%) respectively. neonatal infection and 1-2 million neonates die Female children had more bacterial isolates from infection. These infections include tetanus, 19(73.1%) compared to male 17(70.1%). The sepsis and acute respiratory tract infections. isolates were more sensitive to gentamicin 25(64%), followed by zithromax 23(59%), The umbilical cord is a major route of infection erythromycin 16(41%) and ampicillin 12(31%). in the early neonatal period accounting for the The majority of neonatal infection and many cases of isolates were less sensitive to Penicillin 2(5) and Amoxicillin 10(26), multi neonatal sepsis. Children can also acquire resistance was...