cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Cost-Utility of Routine Endometrial Evaluation Prior to Le Fort Colpocleisis
Creators: name: Kandadai, Padma
name: Flynn, Michael K.
name: Zweizig, Susan
name: Patterson, Danielle
Publisher: name: eScholarship@UMMS
Year: 2012

description: Objective: Endometrial evaluation is routinely performed in elderly women undergoing Le Fort colpocleisis. There is little evidence to support this practice. We sought to investigate the cost-utility of routine evaluation of the uterine cavity prior to performing a Le Fort colpocleisis.

Study Design: A decision analysis model was created to compare uterine evaluation, by either endometrial biopsy or transvaginal ultrasound, to no evaluation for a cohort of women > 80 years old undergoing Le Fort colpocleisis. Baseline assumptions for our model were made to reflect women who did not carry significant risk for the development of endometrial cancer, such as history of postmenopausal bleeding, abnormal uterine pathology, obesity, diabetes, and tamoxifen use. Decision paths included no screening, ultrasound evaluation, and biopsy. The horizon was five years until the endpoint of survival, death, or the development of cancer. Those pathways in which cancer was diagnosed were carried out to the endpoint of either five-year survival or death. Treatment arms for endometrial cancer were based on management methods used at our institution. Probabilities and utilities for health outcomes were estimated through literature review or, when unavailable, by expert opinion. Costs were obtained from US Medicare charges for the appropriate CPT and DRG codes and are reported in 2012 US Dollars. Cost-utility analysis was performed using US recommendations from a societal perspective. Sensitivity analysis using Monte Carlo simulation was performed to test the validity of our model.

Results: Analysis of our decision tree demonstrates that a strategy of no evaluation is superior to that of either biopsy or ultrasound. Univariate sensitivity analysis demonstrates that at a 0.55 probability of cancer, biopsy surpasses both no evaluation and ultrasound as the dominant strategy. Using Monte Carlo simulation, at willingness-to-pay thresholds of $50,000 and $100,000, no evaluation was superior to both biopsy and ultrasound from the patient, health-plan, and societal perspectives. Biopsy appears to be a more effective strategy than ultrasound when uterine evaluation is needed.

Conclusions: Our model shows that a practice of not evaluating the endometrial cavity prior to performing Le Fort colpocleisis is superior to either biopsy or ultrasound. These results are likely being driven by the low incidence of endometrial cancer in this population. It may not be necessary to perform uterine evaluation prior to Le Fort colpocleisis in a low-risk population. If uterine evaluation is needed, biopsy appears to be the preferred strategy over ultrasound. More studies are needed to determine utility values for health states experienced by women with pelvic organ prolapse and with endometrial cancer. This will enhance our ability to develop more accurate cost-utility models for treating these women.
Hyperscaling Violating Solution in Coupled Dilaton-Squared Curvature Gravity
Creators: name: Ghodrati, Mahdis
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering a model with Coupled Dilaton-Squared Curvature terms and a dilatonic potential which replace the cosmological constant, we present an analytic hyperscaling violating solution which is the generalization of arXiv:1305.3279 for non zero $θ$. We show that a specific coupling between dilaton and the squared curvature terms produces a simple logarithmic behavior for the dilaton. By imposing the null energy condition and stability constraints, we investigate the allowed regions for the parameters of this model. We then study the perturbations around $\mathrm{AdS_4} $ in the UV and $\mathrm{\mathrm{AdS}_2\times \mathbb{R}^2} $ in the IR of the Einstein-Weyl gravity which can support an intermediate hyperscaling violating solution in order to resolve the $\mathrm{IR} $ singularity of the metric in 4d.
description: 21 Pages, 17 figures, references added
DepEd Computerization Program: Venue for Improving Teachers Pedagogy
Creators: name: Pañares, Nick
Publisher: name: figshare
Year: 2023
Subjects: Creative arts, media and communication curriculum and pedagogy

description: DepEd Computerization Program (DCP) provided the public schools with appropriate technologies that would enhance the teaching-learning process (DO 78, s. 2010). However, UNESCO Institute for Statistics (April 2014) on their study of Information and Communication Technology (ICT) in Education in Asia data revealed that there were no data yet for public school teachers teaching using ICT and only two (2) percent of the public school teachers were trained to use ICT. Thus, this study was conducted to determine the level of increase in the ICT integration in the lesson after the intervention was given. The study employed the Continuous Improvement (CI) Research Method that includes three (3) main stages: Assess, Analyze and Act. Descriptive statistics were used after the survey responses. Interview and focus group discussions among students and teachers were done to further validate results. A survey questionnaire was adapted from UNESCO ICT Inventory Questionnaire. The paired t-test was used to determine the significant differences between mean scores on ICT teachers' competence. The findings of the study revealed that through mentoring program conducted by the ICT Coordinator, teachers were introduced to various computer applications such as Basic Computer System, Google Drive applications, Graphic tablet and PHET Simulations. There was a total of two hundred fifty percent (250%) increase in the teachers integrating ICT in their classes. And after the first quarter of the school year there was a significant increase in the Teachers ICT Competence. It is then recommended that teachers should make use of the multimedia instruction in their respective schools so as to help students concretize abstract concepts and processes skills which may improve students' academic achievement. Furthermore, there is a need to examine further the type of multimedia used for teaching and learning in relation to exchange of communications for students' better comprehension, as much as possible the multimedia should commensurate to students' cognitive structure.
Assessing Genetic Risks: Implications for Health and Social Policy
Publisher: name: Online Ethics Center
Year: 2016
Subjects: Confidentiality
Emerging Technologies
Ethics and Society
Governance
Human Rights
Human Subjects Research
Law and Public Policy
Privacy and Surveillance
Public Health and Safety
Public Well-being
Risk
Safety
Security

description: Link into the National Academies Report,Assessing Genetic Risks: Implications for Health and Social Policy
Additional file 3 of Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Creators: name: Babunageswararao Kanuri
name: Fong, Vincent
name: Haller, April
name: Hui, David Y.
name: Patel, Shailendra B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Additional file 3.
Additional file 2 of Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Creators: name: Babunageswararao Kanuri
name: Fong, Vincent
name: Haller, April
name: Hui, David Y.
name: Patel, Shailendra B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Additional file 2. Sequencing of off-target products on chromosome 2.
title: CANDI Store: An Infrastructure for Neuroimage Storage and Processing
Creators: name: Haselgrove, Christian
name: Hodge, Steven M.
name: Rane, Pallavi
name: Frazier, Jean A.
name: Kennedy, David N.
Publisher: name: eScholarship@UMMS
Year: 2012

description: In order to support the local data management need for neuroimaging researchers at UMass Medical School within the Child and Adolescent NeuroDevelopment Initiative (CANDI) and beyond, we have implemented a XNAT (xnat.org) instance called CANDIStore. XNAT is an open source imaging informatics platform, developed by the Neuroinformatics Research Group at Washington University. It facilitates common management, productivity, and quality assurance tasks for imaging and associated data. Located securely within the medical school firewall, CANDIStore offers a comprehensive set of image management tools. Users can be authenticated based against their UMass credentials, create private projects, manage research team access, DICOM 'push' directly to CANDIStore from the MRI imaging console, manage demographic and additional subject variables, and perform automated analysis and processing pipelines. CANDIStore is an essential adjunct to the daily operations of neuroimaging research.
Additional file 1 of Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Creators: name: Babunageswararao Kanuri
name: Fong, Vincent
name: Haller, April
name: Hui, David Y.
name: Patel, Shailendra B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Additional file 1: Table S1. Primer sequences.
Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making: Workshop Report
Publisher: name: Online Ethics Center
Year: 2016
Subjects: Ethics and Society
Fabrication
Falsification
Governance
Human Rights
Human Subjects Research
Law and Public Policy
Privacy and Surveillance
Research Misconduct
Responsible Innovation
Safety

description: Link to the National Academies Report,Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making: Workshop Report
title: Gender-Specific Factors Associated with Readiness to Quit Smoking among Korean Americans
Creators: name: Kim, Sun
name: Kalman, David
name: Ziedonis, Douglas M.
Publisher: name: eScholarship@UMMS
Year: 2012

description: Introduction: The study examined gender differences in smoking and factors associated with three stages of readiness to quit smoking (precontemplation with no quit intention in the next 6 months, contemplation with a quit intention in the next 6 months but not in the next month, and preparation with a quit intention in the next month) among Korean Americans.

Method: The study is a telephone survey with a randomly selected sample from an online telephone directory. Inclusion criteria for participation were (a) being of 18 and older, (b) identifying self as Korean, and (c) having smoked daily for at least six months prior to the interview.

Results: The sample comprised 70 women and 168 men with a 63.8% response rate from eligible respondents. Women were 3 years older on average than were men when they started smoking regularly (t = 3.5, p = 0.001). Women were more likely to smoke inside the house than were men (X2 = 16.5, p < 0.001). Compared to women in the preparation stage, women in precontemplation and contemplation stages had decreased odds of perceiving a family norm favoring quitting and increased odds of perceiving risks of quitting. Compared to men in the preparation stage, men in precontemplation and contemplation stages had decreased odds of perceiving a family norm favoring quitting and benefits of quitting. Previous quit attempts were also a significant factor for both women and men.

Conclusions: Korean American female and male smokers are similar in the aspect that they are more likely to be ready to quit when they perceive a family norm favoring quitting. However, they differ in the relationship between perceived risks and benefits of quitting and readiness to quit. These findings underscore the importance of designing gender-tailored smoking cessation interventions in addition to having culture-specific interventions with the group.
Objektepistemologien
Creators: name: Hilgert, Markus
name: Schäfer, Hilmar
name: Frers, Lars
name: Hahn, Hans Peter
name: König, Gudrun M.
name: Bender, Michael
name: Kollatz, Thomas
name: Rapp, Andrea
name: Jung, Matthias
name: Hofmann, Kerstin P.
name: Reiche, Ina
name: Beck, Tina
name: Philipowski, Katharina
name: Schwindt, Jürgen Paul
name: Selz, Gebhard J.
Publisher: name: Edition Topoi
Year: 2018

description: Die sozial- und kulturwissenschaftliche Bewertung der Dinge, ihres epistemischen Status sowie ihres Stellenwerts im Rahmen sozialer Praktiken und damit für das Soziale insgesamt hat in den letzten drei Jahrzehnten eine bemerkenswerte Dynamik entfaltet und eine radikale theoretische Weiterent­wicklung vollzogen. In der aktuellen theoretischen Debatte über die Dinge wird dabei insbesondere die Variabilität und Instabilität der sozialen Praxis sowie die ‘Ambivalenz der Dinge’ betont. Objekt­epistemologien widmen sich der Frage, wie genau multiple und variable Objektidentitäten in der epistemischen Praxis entstehen und wie sie ihrerseits auf diese Praxis zurückwirken. Handlungsoptio­nen an, mit oder infolge von Dingen besitzen jedoch stets auch eine soziale, wirtschaftliche, politi­sche sowie eine ethische Dimension, die ebenfalls wissensbasiert ist und deren Prämissen es gleicher­maßen zu klären gilt. Die Texte des vorliegenden Bandes stellen den Versuch dar, das gegenseitige Abhängigkeitsverhältnis zwischen Dingen und Wissen aufzudecken und in verschiedenen Erscheinungsformen zu analysieren. Dadurch umreißen sie den transdisziplinären Forschungsraum der Objektepistemologien und stellen sein wissenschaftliches Potential unter Beweis.
Additional file 2 of Individualized hemodynamic optimization guided by indirect measurement of the respiratory exchange ratio in major surgery: study protocol for a randomized controlled trial (the OPHIQUE study)
Creators: name: Bar, Stéphane
name: Boivin, Pierre
name: Amine, Younes El
name: Descamps, Richard
name: Moussa, Mouhamed
name: Arab, Osama Abou
name: Marc-Olivier Fischer
name: Dupont, Hervé
name: Lorne, Emmanuel
name: Pierre-Grégoire Guinot
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Additional file 2. Copy of the informed consent form.txt.
Additional file 1 of Individualized hemodynamic optimization guided by indirect measurement of the respiratory exchange ratio in major surgery: study protocol for a randomized controlled trial (the OPHIQUE study)
Creators: name: Bar, Stéphane
name: Boivin, Pierre
name: Amine, Younes El
name: Descamps, Richard
name: Moussa, Mouhamed
name: Arab, Osama Abou
name: Marc-Olivier Fischer
name: Dupont, Hervé
name: Lorne, Emmanuel
name: Pierre-Grégoire Guinot
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Additional file 1. WHO Trial Registration Data Set.txt.
Isomeric pair ${^{95\rm m,g}\rm{Nb}}$ in photonuclear reactions on $^{\rm nat}$Mo at end-point bremsstrahlung energy of 35-95 MeV
Creators: name: Timchenko, I. S.
name: Deiev, O. S.
name: Olejnik, S. M.
name: Potin, S. M.
name: Kushnir, V. A.
name: Mytrochenko, V. V.
name: Perezhogin, S. A.
name: Bocharov, V. A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The ${^{\rm nat}\rm{Mo}}(γ,x\rm np)^{95\rm m,g}$Nb photonuclear reaction was studied using the electron beam from the NSC KIPT linear accelerator LUE-40. Experiment was performed using the activation and off-line $γ$-ray spectrometric technique. The experimental isomeric yield ratio $d(E_{\rm{γmax}}) = Y_{\rm m}(E_{\rm{γmax}}) / Y_{\rm g}(E_{\rm{γmax}})$ was determined for the reaction products $^{95\rm m,g}\rm{Nb}$ at the end-point bremsstrahlung energy $E_{\rm{γmax}}$ range of 35-95 MeV. The obtained values of $d(E_{\rm{γmax}})$ are in satisfactory agreement with the results of other authors and extend the range of previously known data. The theoretical values of the yields $Y_{\rm m,g}(E_{\rm{γmax}})$ and the isomeric yield ratio $d(E_{\rm{γmax}})$ for the isomeric pair $^{95\rm m,g}\rm{Nb}$ from the ${^{\rm nat}\rm{Mo}}(γ,x\rm np)$ reaction were calculated using the partial cross-sections $σ(E)$ from the TALYS1.95 code for six different level density models $LD$. The comparison showed a noticeable excess (more than 3.85 times) of the experimental isomeric yield ratio over all theoretical estimates. At the investigated range of $E_{\rm{γmax}}$ the theoretical dependence of $d(E_{\rm{γmax}})$ on energy was confirmed - the isomeric yield ratio smoothly decreases with increasing energy.
description: 9 pages, 9 figures, 1 table
Ethics Education and Scientific and Engineering Research: What's Been Learned? What Should Be Done? Summary of a Workshop
Publisher: name: Online Ethics Center
Year: 2011
Subjects: Human Subjects Research
Mentors and Trainees
Publication Ethics
Research Misconduct
Workplace Ethics

description: The workshop, summarized in this volume, discussed the social environment of science and engineering education; the need for ethics education for graduate students and postdoctoral fellows in science and engineering; models for effective programs; and assessment of approaches to ethics education, among other topics.
Additional file 1 of Comparison of self-report and administrative data sources to capture health care resource use in people with chronic obstructive pulmonary disease following pulmonary rehabilitation
Creators: name: Grimwood, Chantal L.
name: Holland, Anne E.
name: McDonald, Christine F.
name: Mahal, Ajay
name: Hill, Catherine J.
name: Lee, Annemarie L.
name: Narelle S. Cox
name: Moore, Rosemary
name: Nicolson, Caroline
name: O’Halloran, Paul
name: Aroub Lahham
name: Gillies, Rebecca
name: Burge, Angela T.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1: Supplementary Table 1. Participant features associated with feasibility of self-reported healthcare utilisation data. Supplementary Table 2. Participant features associated with accurate reporting of general practitioner visits. Supplementary Table 3. Participant features associated with accurate reporting of medical specialist appointments. Supplementary Table 4. Participant features associated with accurate reporting of emergency department presentations. Supplementary Table 5. Participant features associated with accurate reporting of hospital admissions.
title: Serum microRNA-122 and miR-155 as biomarkers of liver injury and inflammation in models of acute and chronic liver disease
Creators: name: Bala, Shashi
name: Petrasek, Jan
name: Mundkur, Shiv
name: Catalano, Donna
name: Ward, Jeanine
name: Levin, Ivan
name: Alao, Hawau
name: Kodys, Karen
name: Szabo, Gyongyi
Publisher: name: eScholarship@UMMS
Year: 2012

description: Background: MicroRNAs (miRs) are small non-coding molecules that regulate gene expression. MiRs expression levels change not only in diseased tissues but also in circulation. Further, miRs are stable in frozen samples that make them attractive for biomarker discovery. Recent reports suggest altered expression of circulating miRNAs in various diseases. MiR-122 is highly abundant in hepatocytes where it regulates different metabolic pathways while miR-155 is a central regulator of inflammation. The aim of this study was to evaluate circulating miRNAs as potential markers of hepatocyte damage and inflammation in liver diseases.

Methods: Serum/plasma and liver samples were collected from C57/BL6 mice after: 1. Chronic alcohol feeding with Lieber-deCarli diet containing alcohol or pair-fed diet for 5 weeks 2. Acetaminophen (APAP) administration. 3. TLR9/4 administration. 4. CCL4 administration. Serum/plasma ALT was evaluated and total RNA was analyzed for miRNAs expression with TaqMan MicroRNA assay. Non-parametric Mann-Whitney test was used for statistics.

Results: The alcohol, APAP, TLR9/TLR4 and CCL4, -induced liver injury models all resulted in ALT increase and more important, in increased serum/plasma miR-122 levels compared to control mice. There was a linear correlation between miR-122 and ALT levels. After CCL4 treatment, serum miR-122 was upregulated as early as one week over controls and it remained elevated. No increase in serum miR-122 in Toll like receptor 4 or NADPH oxidase–deficient mice was found after alcohol feeding as these KO mice were protected from alcohol-induced liver injury and inflammation. Alcohol-, APAP, TLR9/TLR4 and CCL4-induced liver damage all involve in activation of the inflammatory cascade. Consistent with this, we found increased serum miR-155 levels.

Conclusion: Our novel results show that serum/plasma miR-122 up-regulation correlates with ALT, thus, miR-122 could be a useful biomarker in acute and chronic liver injury. We also report that serum miR-155 is increased in liver disease with inflammation.
title: Knowledge of and perceived need for evidence-based educational materials about antipsychotic medication safety by nursing home staff
Creators: name: Lemay, Celeste A.
name: Foy, Sarah
name: Mazor, Kathleen M.
name: Harrold, Leslie R.
name: Donovan, Jennifer L.
name: Kanaan, Abir O.
name: Briesacher, Becky A.
name: Gurwitz, Jerry H.
name: Tjia, Jennifer
Publisher: name: eScholarship@UMMS
Year: 2012

description: Background: Given the widespread overuse of antipsychotic medications among US nursing home (NH) residents, we sought to identify knowledge of and perceived need for the AHRQ Comparative Effectiveness Research Summary Guide (CERSG) “Off-Label Use of Atypical Antipsychotic Drugs”.

Methods: We conducted a baseline needs assessment with 12 NHs participating in a randomized controlled trail evaluating evidence dissemination strategies. Using a mixed method approach, we conducted in-depth assessments of knowledge, attitudes, and practice behavior using telephone interviews with NH leadership (administrators, directors of nursing [DON], and medical directors), and questionnaires with NH leadership, consultant pharmacists and direct care staff. Interviews were transcribed, verbatim responses were coded independently by 2 project staff. The coding scheme was revised after each round until substantial agreement (85%) was reached.

Results: Interviews revealed that 70% of medical directors and 46% of DON and administrators believed that antipsychotics decreased agitation and controlled harmful behavior; 50% of medical directors and 7% of DONs & administrators reported knowledge of the increased risk of morbidity and mortality due to atypical antipsychotics. Half of administrators and DONs expressed interest in receiving information for NH staff pertaining to understanding dementia and dementia-related behaviors, 42% believed families would benefit from information about antipsychotic use for dementia-related behaviors. Questionnaire results were similar. When leaders were asked to list any risks associated with antipsychotic use for residents with dementia, only 17% reported death as a possible adverse event; licensed nursing staff (RN and LPNs) reported death 5% of the time. Over half of consultant pharmacists identified that their biggest barrier to improving medication use in challenging NHs was physician resistance to accepting recommendations.

Conclusions: The responses of the NH leaders, staff and consultant pharmacists suggest widespread knowledge gaps regarding antipsychotic benefits and risks, and suggest a need for increase evidence dissemination and broad organizational change.
Research in the Life Sciences with Dual Use Potential: An International Faculty Development Project on Education About the Responsible Conduct of Science
Publisher: name: Online Ethics Center
Year: 2012
Subjects: Controversies
Dual Use Research
Ethics and Society
Safety
Security
Social Responsibility

description: Link to the National Academies Report,Research in the Life Sciences with Dual Use Potential: An International Faculty Development Project on Education About the Responsible Conduct of Science.
CECM: A continuous empirical cubature method with application to the dimensional hyperreduction of parameterized finite element models
Creators: name: Hernandez, J. A.
name: Bravo, J. R.
name: de Parga, S. Ares
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We present the Continuous Empirical Cubature Method (CECM), a novel algorithm for empirically devising efficient integration rules. The CECM aims to improve existing cubature methods by producing rules that are close to the optimal, featuring far less points than the number of functions to integrate. The CECM consists on a two-stage strategy. First, a point selection strategy is applied for obtaining an initial approximation to the cubature rule, featuring as many points as functions to integrate. The second stage consists in a sparsification strategy in which, alongside the indexes and corresponding weights, the spatial coordinates of the points are also considered as design variables. The positions of the initially selected points are changed to render their associated weights to zero, and in this way, the minimum number of points is achieved. Although originally conceived within the framework of hyper-reduced order models (HROMs), we present the method's formulation in terms of generic vector-valued functions, thereby accentuating its versatility across various problem domains. To demonstrate the extensive applicability of the method, we conduct numerical validations using univariate and multivariate Lagrange polynomials. In these cases, we show the method's capacity to retrieve the optimal Gaussian rule. We also asses the method for an arbitrary exponential-sinusoidal function in a 3D domain, and finally consider an example of the application of the method to the hyperreduction of a multiscale finite element model, showcasing notable computational performance gains. A secondary contribution of the current paper is the Sequential Randomized SVD (SRSVD) approach for computing the Singular Value Decomposition (SVD) in a column-partitioned format. The SRSVD is particularly advantageous when matrix sizes approach memory limitations.
title: Induction of Colon Cancer Cell Death by Cranberry Proanthocyanidins via MAPK Pathway
Creators: name: Liberty, Anne M.
name: Ferreira, Tracie P.
name: Neto, Catherine C.
Publisher: name: eScholarship@UMMS
Year: 2012

description: The potential ability of dietary cranberry to inhibit colon carcinogenesis is under investigation. Compounds isolated from locally grown cranberry fruit (Vaccinium macrocarpon) have been shown in vitro to decrease proliferation of colon cancer cells, in part by induction of apoptosis. These compounds include oligomeric polyphenols known as proanthocyanidins (PACs) containing two or more epicatechin units with different types of linkages. To further elucidate the mechanism by which PACs induce cell death, we transcriptionally profiled cells treated with PACs. HCT116 and HT29 colon cancer cells were exposed to a cranberry proanthocyanidin (PACs) fraction isolated from Early Black variety cranberry fruit, at time intervals of 6, 12, 18 and 24 hours. Total RNA was extracted from PAC-treated and untreated control cells. Transcriptional profiling was performed using an Illumina microarray bead system. Microarray results revealed that expression of several members of the mitogen activated protein kinase family (MAPK) was significantly altered in the presence of PACs, leading to decreased transcription of genes in the nucleus and decreased tumor cell growth. Quantitative (Q)-PCR was used to confirm microarray data showing gene expression changes in some key apoptotic pathways. Western blotting was used to confirm the up- regulation or down-regulation of key proteins involved in the MAPK pathway. Significant changes in p53, APAF and VEGF protein expression were seen as early as eighteen hours. Flow cytometry was employed to identify changes in the cell cycle due to exposure to PACs. HCT116 and HT29 colon cancer cells showed a significant change in granularity and a significant increase in G2 arrest compared to control when exposed to PACs for as little as six hours. This study has provided insight into mechanisms by which cranberry PACs may inhibit colon cancer.
Heavy quarkonia in QGP medium in an arbitrary magnetic field
Creators: name: Sebastian, Jobin
name: Thakur, Lata
name: Mishra, Hiranmaya
name: Haque, Najmul
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the heavy quarkonium complex potential in an arbitrary magnetic field strength generated in the relativistic heavy-ion collision. First, the one-loop gluon polarization tensor is obtained in the presence of an external, constant, and homogeneous magnetic field using the Schwinger proper time formalism in Euclidean space. The gluon propagator is computed from the gluon polarization tensor, and it is used to calculate the dielectric permittivity in the presence of the magnetic field in the static limit. The modified dielectric permittivity is then used to compute the heavy quarkonium complex potential. We find that the heavy quarkonium complex potential is anisotropic in nature, which depends on the angle between the quark-antiquark ($Q\bar{Q}$) dipole axis and the direction of the magnetic field. We discuss the effect of the magnetic field strength and the angular orientation of the dipole on the heavy quarkonium potential. We discuss how the magnetic field influences the thermal widths of quarkonium states. Further, we also discuss the limitation of the strong-field approximation as done in literature in the light of heavy-ion observables, as the effect of the magnetic field is very nominal to the quarkonium potential.
description: 13 pages, 6 figures, Published version
Additional file 1 of Comparing methods of performing geographically targeted rural health surveillance
Creators: name: Lee, David C.
name: McGraw, Nancy A.
name: Doran, Kelly M.
name: Mengotto, Amanda K.
name: Wiener, Sara L.
name: Vinson, Andrew J.
name: Thorpe, Lorna E.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1. Supplemental Appendix and Figures.
Accelerating Dynamic Network Embedding with Billions of Parameter Updates to Milliseconds
Creators: name: Deng, Haoran
name: Yang, Yang
name: Li, Jiahe
name: Cai, Haoyang
name: Pu, Shiliang
name: Jiang, Weihao
Publisher: name: arXiv
Year: 2023
Subjects: subject: Social and Information Networks (cs.SI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Network embedding, a graph representation learning method illustrating network topology by mapping nodes into lower-dimension vectors, is challenging to accommodate the ever-changing dynamic graphs in practice. Existing research is mainly based on node-by-node embedding modifications, which falls into the dilemma of efficient calculation and accuracy. Observing that the embedding dimensions are usually much smaller than the number of nodes, we break this dilemma with a novel dynamic network embedding paradigm that rotates and scales the axes of embedding space instead of a node-by-node update. Specifically, we propose the Dynamic Adjacency Matrix Factorization (DAMF) algorithm, which achieves an efficient and accurate dynamic network embedding by rotating and scaling the coordinate system where the network embedding resides with no more than the number of edge modifications changes of node embeddings. Moreover, a dynamic Personalized PageRank is applied to the obtained network embeddings to enhance node embeddings and capture higher-order neighbor information dynamically. Experiments of node classification, link prediction, and graph reconstruction on different-sized dynamic graphs suggest that DAMF advances dynamic network embedding. Further, we unprecedentedly expand dynamic network embedding experiments to billion-edge graphs, where DAMF updates billion-level parameters in less than 10ms.
Medium Resolution Near-Infrared Spectra of the Host Galaxies of Nearby Quasars
Creators: name: Le, Huynh Anh N.
name: Pak, Soojong
name: Im, Myungshin
name: Kim, Minjin
name: Sim, Chae Kyung
name: Ho, Luis C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present medium resolution near-infrared host galaxy spectra of low redshift quasars, PG 0844 + 349 (z=0.064), PG 1226 + 023 (z=0.158), and PG 1426+015 (z=0.086). The observations were done by using the Infrared Camera and Spectrograph (IRCS) at the Subaru 8.2 m telescope. The full width at half maximum of the point spread function was about 0.3 arcsec by operations of an adaptive optics system, which can effectively resolve the quasar spectra from the host galaxy spectra. We spent up to several hours per target and developed data reduction methods to reduce the systematic noises of the telluric emissions and absorptions. From the obtained spectra, we identified absorption features of Mg I (1.503 um), Si I (1.589 um) and CO (6-3) (1.619 um), and measured the velocity dispersions of PG 0844 + 349 to be 132+/-110 km s-1 and PG 1426 + 015 to be 264+/-215 km s-1. By using an M_BH-sigma relation of elliptical galaxies, we derived the black hole (BH) mass of PG 0844+349, log(M_BH/M_SUN) = 7.7+/-5.5 and PG 1426+015, log(M_BH/M_SUN) = 9.0+/-7.5. These values are consistent with the BH mass values from broad emission lines with an assumption of a virial factor of 5.5.
description: 16 pages, 5 figures
title: Utilization and Outcomes of Patients with Colorectal Cancer Liver Metastases in the Medicare Population
Creators: name: Macomber, Christopher W.
name: Chau Ng, Sing
name: Li, Youfu
name: Alavi, Karim
name: Santry, Heena P.
name: Tseng, Jennifer
name: Shah, Shimul A.
Publisher: name: eScholarship@UMMS
Year: 2012

description: Aggressive treatment of colorectal liver metastases (CRLM) after colectomy is increasing in the last two decades with reports of improved survival. Multiple treatment options are available for CRLM but their use and utility remains unknown.

Methods: Using SEER-Medicare linked database (1991-2005), we identified 7131 patients who had undergone colectomy with CRLM. Demographic, clinical and tumor factors were examined as determinants of therapy. Treatment options consisted of surgery (resection, ablation) or chemotherapy. Univariate and multivariate analyses were performed to determine predictors of overall survival after colectomy.

Results: 635 patients (8.9%) underwent liver directed surgery defined as either a liver resection (n=495), ablation (n=216) or both (n=76) for CRLM. 322 patients (51%) were female and 313 (49%) were male. 147 patients (23%) were SES 1, 230 patients (36%) were SES 2, and 258 (41%) were SES 3. There was a survival advantage to receiving liver surgery or chemotherapy in selected patients with CRLM (p<0.001). Of the 635 patients who received liver surgery, 62.7% received chemotherapy within 6 months of surgery. Adjusted overall survival after colectomy was greatest in Asian/Other race; poor prognostic indicators included increasing comorbidities, advanced age and development of complications within one month after liver surgery.

Conclusion: In the Medicare population, patients with CRLM who receive potentially curative therapy such as resection, ablation or chemotherapy experience a substantial survival advantage; despite this only 8.9% of patients received directed therapy for their metastasis. Barriers to treatment and its underutilization must be identified to improve survival in patients diagnosed with CRLM after colectomy.
Black Holes with Abelian and Non-Abelian Charges and Their Impact on Matter Accretion Flows
Creators: name: Gómez, Gabriel
name: Rincón, Ángel
name: Cruz, Norman
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the black hole spacetime structure of a model consisting of the standard Maxwell theory and a $p$-power-Yang-Mills term. This non-linear contribution introduces a non-Abelian charge into the global solution, resulting in a modified structure of the standard Reissner-Nordström black hole. Specifically, we focus on the model with $p=1/2$, which gives rise to a new type of modified Reissner-Nordström black hole. For this class of black holes, we compute the event horizon, the innermost stable circular orbit, and the conditions to preserve the weak cosmic censorship conjecture. The latter condition sets a well-established relation between the electric and the Yang-Mills charges. As a first astrophysical implication, the accretion properties of spherical steady flows are investigated in detail. Extensive numerical examples of how the Yang-Mills charge affects the accretion process of an isothermal fluid in comparison to the standard Reissner-Nordström and Schwarzschild black holes are displayed. Finally, analytical solutions in the fully relativistic regime, along with numerical computations, of the mass accretion rate for a polytropic fluid in terms of the electric and Yang-Mills charges are obtained. As a main result, the mass accretion rate efficiency is considerably improved, with respect to the standard Reissner-Nordström and Schwarzschild solutions, for negative values of the Yang-Mills charge.
description: 19 pages, 8 figures. References updated, some comments included and figure 1 added to match published version
Von der ‚Ambivalenz der Dinge‘ zur Objekt-Politik
Creators: name: Hilgert, Markus
Publisher: name: Edition Topoi
Year: 2018

description: Objektepistemologien fragen nach dem ‚Was‘, dem ‚Wie‘, dem ‚Warum (so)‘ und dem ‚Wozu‘ von vergangenen und gegenwärtigen Diskursen zu, Konzeptualisierungen von und Handlungsroutinen an, mit und infolge von Dingen. In ihrem Zentrum stehen das Wissen über die Dinge mit den darin vielfach implizit enthaltenen Konzeptualisierungen von Dingen sowie der Zusammenhang zwischen diesem Dingwissen und der epistemischen oder szientifischen Praxis. Dabei erweisen sich die in der Dingpraxis ausgedrückten Zuschreibungen an Dinge als variabel, differentiell und temporär. Der Beitrag führt in den innovativen, transdisziplinären Forschungsraum der Objektepistemologien ein und kontextualisiert ihn theoriegeschichtlich. Außerdem bietet er einen Überblick über die weiteren Beiträge des Sammelbandes.
title: Primary Care Physicians’ Views on Medical Error and Disclosure in Cancer Care
Creators: name: Mazor, Kathleen M.
name: Firneno, Cassandra L.
name: Lemay, Celeste A.
name: Roblin, Douglas W.
name: Greene, Sarah M.
name: Prouty, Carolyn
name: Lapham, Beth
name: Robinson, Brandi
name: Dunlap, Ben
name: Anau, Jane
name: Gallagher, Thomas
Publisher: name: eScholarship@UMMS
Year: 2012

description: Introduction: Effective physician-patient communication is critical in cancer care. Breakdowns in communication may follow an actual or suspected medical error because of various professional or medicolegal concerns about those events. We examined views of primary care physicians (PCPs) regarding two hypothetical medical errors, their perceptions of responsibility and intent to communicate these events to patients.

Objectives: To describe PCPs views on medical errors, perceived responsibility and communication after errors during cancer care.

Methods: We surveyed 630 PCPs at 3 healthcare organizations participating in the Cancer Research Network. Questionnaires included two vignettes describing possible medical errors: a delayed diagnosis of breast cancer and; preventable complications of colon cancer treatment. Questions assessed perceived responsibility and intent to communicate with the patient after the event.

Results: A total of 333 PCPs responded (response rate =53%). Eighty-one percent felt that the delayed diagnosis vignette described a serious error; (60%) believed that the preventable complications of colon cancer treatment vignette represented a serious medical error. Few would offer no apology at all for the delayed diagnosis (4%) or the colon cancer complications complications (7%). The most common expression of regret was “I am sorry about what happened to you” without elaboration (48% delayed diagnosis; 56% complications). Just over half (51%) would not volunteer the cause of the delayed diagnosis; compared to 25% in the complications vignette. Perception of the error as serious, and of greater personal responsibility were both predictive of being more forthcoming when communicating to patient after the event; perceived self-efficacy in communication and the belief that one’s organization values good communication were not.

Conclusion: PCPs vary in their attitudes towards medical errors, and their perceptions of responsibility. These attitudes and perceptions are predictive of how physicians intend to communicate with patients after such events, at least in response to two hypothetical cases.
NuSTAR and AstroSat observations of GX 9$+$1: Spectral and temporal studies
Creators: name: Thomas, Neal Titus
name: Gudennavar, S. B.
name: Bubbly, S. G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We have studied the spectro-temporal properties of the neutron star low mass X-ray binary GX 9$+$1 using data from \textit{NuSTAR/FPM} and \textit{AstroSat/SXT} and \textit{LAXPC}. The hardness-intensity diagram of the source showed it to be in the soft spectral state during both observations. \textit{NuSTAR} spectral analysis yielded an inclination angle ($θ$) $=$ 29$\substack{+3\\-4}^{\circ}$ and inner disk radius ($R_{in}$) $\leq$ 19.01 km. Assuming that the accretion disk was truncated at the Alfvén radius during the observation, the upper limit of the magnetic dipole moment ($μ$) and the magnetic field strength ($B$) at the poles of the neutron star in GX 9$+$1 were calculated to be 1.45$\times$$10^{26}$ G cm$^3$ and 2.08$\times$$10^8$ G, respectively (for $k_A$ $=$ 1). Flux resolved spectral analysis with \textit{AstroSat} data showed the source to be in the soft spectral state ($F_{disk}$/$F_{total}$ $\sim$0.9) with a monotonic increase in mass accretion rate ($\dot{m}$) along the banana branch. The analysis also showed the presence of absorption edges at $\sim$1.9 and $\sim$2.4 keV, likely due to Si XIII and S XV, respectively. Temporal analysis with \textit{LAXPC-20} data in the 0.02 $-$ 100 Hz range revealed the presence of noise components, which could be characterized with broad Lorentzian components.
Additional file 1 of Management of pharmaceutical and recreational drug poisoning
Creators: name: Mégarbane, Bruno
name: Oberlin, Mathieu
name: Alvarez, Jean-Claude
name: Balen, Frederic
name: Beaune, Sébastien
name: Bédry, Régis
name: Chauvin, Anthony
name: Claudet, Isabelle
name: Danel, Vincent
name: Debaty, Guillaume
name: Delahaye, Arnaud
name: Deye, Nicolas
name: Jean-Michel Gaulier
name: Grossenbacher, Francis
name: Hantson, Philippe
name: Jacobs, Frédéric
name: Jaffal, Karim
name: Labadie, Magali
name: Labat, Laurence
name: Langrand, Jérôme
name: Lapostolle, Frédéric
name: Conte, Philippe Le
name: Maignan, Maxime
name: Nisse, Patrick
name: Sauder, Philippe
name: Tournoud, Christine
name: Vodovar, Dominique
name: Voicu, Sebastian
name: Pierre-Géraud Claret
name: Cerf, Charles
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1. Classification of the new psychoactive substances (NPS). Figure S1. Examples of new psychoactive substances (NPS) mimicking the psychoactive effects of “traditional” molecules. Figure S2. The Drugs Wheel, A new model for substance awareness [UK version 2.0.7 dated 08/09/2018— www.thedrugswheel.com .]
The accretion-ejection coupling in the black hole candidate X-ray binary MAXI J1836-194
Creators: name: Russell, T. D.
name: Soria, R.
name: Miller-Jones, J. C. A.
name: Curran, P. A.
name: Markoff, S.
name: Russell, D. M.
name: Sivakoff, G. R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the results of our quasi-simultaneous radio, sub-mm, infrared, optical and X-ray study of the Galactic black hole candidate X-ray binary MAXI J1836-194 during its 2011 outburst. We consider the full multi-wavelength spectral evolution of the outburst, investigating whether the evolution of the jet spectral break (the transition between optically-thick and optically-thin synchrotron emission) is caused by any specific properties of the accretion flow. Our observations show that the break does not scale with the X-ray luminosity or with the inner radius of the accretion disk, and is instead likely to be set by much more complex processes. We find that the radius of the acceleration zone at the base of the jet decreases from ~10$^6$ gravitational radii during the hard intermediate state to ~10$^3$ gravitational radii as the outburst fades (assuming a black hole mass of 8 M$_{\odot}$), demonstrating that the electrons are accelerated on much larger scales than the radius of the inner accretion disk and that the jet properties change significantly during outburst. From our broadband modelling and high-resolution optical spectra, we argue that early in the outburst, the high-energy synchrotron cooling break was located in the optical band, between $\approx 3.2 \times 10^{14}$ Hz and $4.5 \times 10^{14}$ Hz. We calculate that the jet has a total radiative power of $\approx 3.1 \times 10^{36}$ ergs s$^{-1}$, which is ~6% of the bolometric radiative luminosity at this time. We discuss how this cooling break may evolve during the outburst, and how that evolution dictates the total jet radiative power. Assuming the source is a stellar-mass black hole with canonical state transitions, from the measured flux and peak temperature of the disk component we constrain the source distance to be 4-10 kpc.
description: 15 pages, accepted for publication in MNRAS
Praxeologische Impulse für die Objektepistemologie
Creators: name: Schäfer, Hilmar
Publisher: name: Edition Topoi
Year: 2018

description: Der Beitrag diskutiert die Konsequenzen einer praxeologischen Perspektive, die ausgehend vom Konzept der Wiederholung ein relationales Denken entfaltet, für das Verständnis der Beziehungen zwischen Praxis, Materialität und Historizität. Er bietet zunächst einen Einblick in die Charakteristika der Praxistheorie und entwickelt ein dynamisches Verständnis von Wiederholung, das er in das Zentrum der praxeologischen Analyse stellt. Im zweiten Teil diskutiert er neun theoretische und methodologische Thesen zum Zusammenhang von Praxis, Materialität und Historizität. Sie behandeln unter anderem die Einbettung von Subjekten in relationale Netze aus Praktiken und Materialitäten, den analytischen Zugang zu historischen Praktiken, das Verhältnis zwischen Gegenwart und Vergangenheit sowie die transitive Methodologie der Praxistheorie.