cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Zero-shot Explainable Mental Health Analysis on Social Media by Incorporating Mental Scales
Creators: name: Li, Wenyu
name: Zhu, Yinuo
name: Lin, Xin
name: Li, Ming
name: Jiang, Ziyue
name: Zeng, Ziqian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Traditional discriminative approaches in mental health analysis are known for their strong capacity but lack interpretability and demand large-scale annotated data. The generative approaches, such as those based on large language models (LLMs), have the potential to get rid of heavy annotations and provide explanations but their capabilities still fall short compared to discriminative approaches, and their explanations may be unreliable due to the fact that the generation of explanation is a black-box process. Inspired by the psychological assessment practice of using scales to evaluate mental states, our method which is called Mental Analysis by Incorporating Mental Scales (MAIMS), incorporates two procedures via LLMs. First, the patient completes mental scales, and second, the psychologist interprets the collected information from the mental scales and makes informed decisions. Experimental results show that MAIMS outperforms other zero-shot methods. MAIMS can generate more rigorous explanation based on the outputs of mental scales
description: 4 pages,2 figures
A Distinct Radial Acceleration Relation across Brightest Cluster Galaxies and Galaxy Clusters
Creators: name: Tian, Yong
name: Ko, Chung-Ming
name: Li, Pengfei
name: McGaugh, Stacy
name: Poblete, Shemile L.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent studies reveal a radial acceleration relation (RAR) in galaxies, which illustrates a tight empirical correlation connecting the observational acceleration and the baryonic acceleration with a characteristic acceleration scale. However, a distinct RAR has been revealed on BCG-cluster scales with a seventeen times larger acceleration scale by the gravitational lensing effect. In this work, we systematically explored the acceleration and mass correlations between dynamical and baryonic components in 50 Brightest Cluster Galaxies (BCGs). To investigate the dynamical RAR in BCGs, we derived their dynamical accelerations from the stellar kinematics using the Jeans equation through Abel inversion and adopted the baryonic mass from the SDSS photometry. We explored the spatially resolved kinematic profiles with the largest integral field spectroscopy (IFS) data mounted by the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey. Our results demonstrate that the dynamical RAR in BCGs is consistent with the lensing RAR on BCG-cluster scales as well as a larger acceleration scale. This finding may imply that BCGs and galaxy clusters have fundamental differences from field galaxies. We also find a mass correlation, but it is less tight than the acceleration correlation.
description: 10 pages, 6 figures
Agrilus pecirkai Obenberger 1916
Creators: name: Jendek, Eduard
name: Nakládal, Oto
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus pecirkai

description: Agrilus pecirkai Obenberger, 1916
Examined specimens. KYRGYZSTAN. Jalal-Abad. Namangan region, 7km W Aflatun; 41°38'18"N, 071°49'47"E; 6-2017; alt. 1300 m; 2 (RRPC). TAJIKISTAN. Region of Republican Subordination. Khoja Obi Garm, Varzobskiy rayon; 38°53'46"N, 068°46'59"E; 6-2018; alt. 2000–2200 m; Adult host: Rosa; 4 (EJCB) // Shirkent National Park, Shakhrinavskiy rayon; 38°41'55"N, 068°21'47"E; 6-2018; alt. 1200–1400 m; Adult host: Rosa; 3 (EJCB).
Host plant cited. Adult: Rosa.
Distribution. KAZAKHSTAN: South Kazakhstan; KYRGYZSTAN; TAJIKISTAN: TURKMENISTAN; UZBEKISTAN.
Remarks. The species is unknown from Iran and Turkey. The records of Jendek (2016: 37) are misidentifications of A. cuprescens (Iran: Mazandaran), A. macroderus (Turkey: Zonguldak) and a new species (Iran: Kerman).
description: Published as part of Jendek, Eduard & Nakládal, Oto, 2019, Taxonomic, distributional and biological study of the genus Agrilus (Coleoptera: Buprestidae). Part II, pp. 401-459 in Zootaxa 4554 (2) on page 432, DOI: 10.11646/zootaxa.4554.2.5, http://zenodo.org/record/2623782
Additional file 2: of Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis
Creators: name: Fusheng Zhou
name: Changbing Shen
name: Jingkai Xu
name: Gao, Jing
name: Xiaodong Zheng
name: Ko, Randy
name: Jinfa Dou
name: Yuyan Cheng
name: Caihong Zhu
name: Shuangjun Xu
name: Xianfa Tang
name: Xianbo Zuo
name: Xianyong Yin
name: Cui, Yong
name: Liangdan Sun
name: Tsoi, Lam
name: Yi-Hsiang Hsu
name: Yang, Sen
name: Xuejun Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S1. Genomic annotation for methylation probes. Refseq genes annotations were from the University of California, Santa Cruz (UCSC) hg18 reference genome [National Center for Biotechnology Information (NCBI) Reference Sequence Database Release 37]. CpG sites located in or near Refseq genes are separated into TSS1500 (1500 bp upstream of the transcription start site), TSS200, 5â ˛ UTR, first exon, gene body, and 3â ˛ UTR regions. Intergenic probes refer to methylation sites not mapping to any of the other categories. The ambiguous regions include sites that fell into two or more different categories. The promoter region includes methylation sites located in TSS1500, TSS200, 5â ˛ UTR, and first exon. (DOC 92 kb)
Three-dimensional acetabular orientation during periacetabular osteotomy: A videoanalysis of acetabular rim position using an external fixator as navigation tool during reorientation procedure
Creators: name: Schwarz, Timo J.
name: Maderbacher, Günther
name: Leiss, Franziska
name: Grifka, Joachim
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: FOLLOW-UP; TRIPLE OSTEOTOMY; CUP MEASUREMENT; DYSPLASIA; SURVIVORSHIP; HIPS; THA; Periacetabular osteotomy; Retroversion; Dysplasia; Hip surgery; Impingement; Navigation
subject: 610 Medizin

description: Introduction Bernese periacetabular osteotomy is an effective procedure for treating acetabular dysplasia. However, limited visual control of the acetabular position during surgery may result in under- or overcorrection with residual dysplasia or femoroacetabular impingement. Thus, we wanted to find a simple method to control the effect of correction in the sagittal and coronal plane. Method The acetabular coordinates are shown by two perpendicular tubes of an external fixator mounted onto a third tube that is fixed to the acetabular fragment with two Schanz screws. This method enables the isolated acetabular reorientation in the coronal, sagittal, and transverse plane. In a sawbone pelvis model, the acetabular rim is marked with a copper wire and a silicon adherent. To show the radiographic effect on acetabular parameters and the rim position, we visualized correction in the coronal and sagittal plane under fluoroscopic control. Results Lateral rotation of the acetabular fragment had the highest impact on radiographic lateral coverage of the femoral head. But also ventral coverage increased during isolated lateral rotation. Anterior rotation showed almost no effect on lateral coverage and just a little effect on ventral coverage but caused severe total acetabular retroversion. Conclusion Three-dimensional control of the acetabular orientation during periacetabular osteotomy is important to avoid over- and under-correction. Isolated lateral rotation of the acetabular fragment should be the predominant direction of correction during periacetabular osteotomy. Ambitious anterior correction may be the main source for severe acetabular retroversion following periacetabular osteotomy.
Appearance in acne: an often-overlooked concept
Creators: name: Gabes, Michaela
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: 610 Medizin

description: Acne is one of the most common skin conditions affecting all age groups, especially adolescents and young adults.1 The transition into adulthood is a crucial period of development including many changes and challenges, such as professional progress, making and strengthening relationships and forming one's personal identity.2 Having visible acne impedes these developmental tasks and, in the absence of a cure, affected people must learn to live with their skin condition. Effective treatments are therefore essential. In order to measure efficacy of different treatments, well‐developed and validated patient‐reported outcome measures should be available and capture improvements from the patient's perspective.3 Being an important outcome of acne treatments, appearance should be measured in every clinical trial. What is more important for an affected patient, especially for adolescents and young adults, than how their skin, acne and acne scars look and improve? Because appearance is in the eye of the beholder, a self‐report is needed to capture this concept. There are some acne‐specific measures available, but they often overlook this subjective concept. In this issue of the BJD, Klassen et al. dared to develop a new instrument filling this gap, the ACNE‐Q.4 Addressing the concept appearance comprehensively, this measure is novel. An important criterion to ensure good quality of the development of a measure is a patient‐oriented approach. Patients as well as different healthcare providers were involved in the whole development process. Three top‐level domains with several major and minor themes emerged. Feedback of clinical experts was obtained and cognitive interviews with affected patients were conducted to assess content validity of the scales according to the COSMIN criteria.5 Modern psychometric analyses using the Rasch Measurement Theory were performed to identify items with poor fit and different measurement properties of the ACNE‐Q, such as structural validity, internal consistency, test–retest reliability and construct validity, were assessed. The study is limited to the North American population. However, a large sample size (n = 256) recruited from two countries and different settings, i.e. hospital and community dermatology clinics, was involved in the validation study. Although the ACNE‐Q is quite long, with 73 items in seven scales, it is a comprehensive and promising measure that can be used in clinical practice and research to measure appearance and appearance‐related distress and symptoms. This study lays the ground for future studies on the validation and feasibility of the ACNE‐Q.
Additional file 4: Figure S4. of Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
Creators: name: Kuznetsova, Tatyana
name: Wang, Shuang-Yin
name: Nagesha Rao
name: Mandoli, Amit
name: Martens, Joost
name: Rother, Nils
name: Aartse, Aafke
name: Laszlo Groh
name: Janssen-Megens, Eva
name: Guoliang Li
name: Yijun Ruan
name: Logie, Colin
name: Stunnenberg, Hendrik
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Complex epigenetic changes induced by co-activated GR and p65. An example screenshot depicting the GR-dependent (blue box), p65-dependent (red box), and co-stimulation-dependent (black box) induced P300 DBSs and constitutive DBSs. Dynamic changes in DNase I accessibility, epigenetic modifications, and RNA-POLII activity on genes upon co-activation are noticeable characteristics of this locus. (PDF 236 kb)
Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy
Creators: name: Markowiak, Till Marvin
name: Kerner, Nadine
name: Neu, Reiner
name: Potzger, Tobias
name: Großer, Christian
name: Zeman, Florian
name: Hofmann, Hans‐Stefan
name: Ried, Michael
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: MALIGNANT PLEURAL MESOTHELIOMA; EXTRAPLEURAL PNEUMONECTOMY; CISPLATIN CONCENTRATION; SODIUM THIOSULFATE; PHASE-II; AMIFOSTINE; PERFUSION; PLEURECTOMY/DECORTICATION; CYTOPROTECTION; NEPHROTOXICITY; cytoprotection; hyperthermic intrathoracic chemotherapy; hyperthermic intrathoracic chemotherapy; nephroprotection; renal insufficiency
subject: 610 Medizin

description: Background and Objectives Hyperthermic intrathoracic chemotherapy (HITOC) is used for the treatment of malignant pleural tumors. Although HITOC proved to be safe, postoperative renal failure due to nephrotoxicity of intrapleural cisplatin remains a concern. Methods This single-center study was performed retrospectively in patients who underwent pleural tumor resection and HITOC between September 2008 and December 2018. Results A total of 84 patients (female n = 33; 39.3%) with malignant pleural tumors underwent surgical cytoreduction with subsequent HITOC (60 minutes; 42 degrees C). During the study period, we gradually increased the dosage of cisplatin (100-150 mg/m(2) BSA n = 36; 175 mg/m(2) BSA n = 2) and finally added doxorubicin (cisplatin 175 mg/m(2) BSA/doxorubicin 65 mg; n = 46). All patients had perioperative fluid balancing. The last 54 (64.3%) patients also received perioperative cytoprotection. Overall 29 patients (34.5%) experienced renal insufficiency. Despite higher cisplatin concentrations, patients with cytoprotection showed significantly lower postoperative serum creatinine levels after 1 week (P = .006) and at discharge (P = .020). Also, they showed less intermediate and severe renal insufficiencies (5.6% vs 13.3%). Conclusions Adequate perioperative fluid management and cytoprotection seem to be effective in protecting renal function. This allows the administration of higher intracavitary cisplatin doses without raising the rate of renal insufficiencies.
MOESM3 of
                     HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Creators: name: Xue, Feng
name: Higgs, Brandon
name: Jiaqi Huang
name: Morehouse, Chris
name: Zhu, Wei
name: Yao, Xin
name: Brohawn, Philip
name: Xiao, Zhan
name: Yinong Sebastian
name: Liu, Zheng
name: Xia, Yun
name: Shen, Dong
name: Kuziora, Mike
name: Zhengwei Dong
name: Hulin Han
name: Gu, Yi
name: Jianren Gu
name: Xia, Qiang
name: Yihong Yao
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: Additional file 3. Supplementary Tables.
Additional file 1: of Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis
Creators: name: Fusheng Zhou
name: Changbing Shen
name: Jingkai Xu
name: Gao, Jing
name: Xiaodong Zheng
name: Ko, Randy
name: Jinfa Dou
name: Yuyan Cheng
name: Caihong Zhu
name: Shuangjun Xu
name: Xianfa Tang
name: Xianbo Zuo
name: Xianyong Yin
name: Cui, Yong
name: Liangdan Sun
name: Tsoi, Lam
name: Yi-Hsiang Hsu
name: Yang, Sen
name: Xuejun Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Table S1. Psoriasis-associated DMSs that are controlled by SNPs. Table S2 Disease severity and position of MethQTL CpGs. Table S3 The association between psoriasis and MethQTL-SNPs in MHC region. Table S4 The results of SNP-CpG pairs that mediate the genetic risk of psoriasis. Table S5 Cross validation between Illumina and Sequenom platform. (DOCX 112 kb)
Additional file 2: Figure S2. of Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
Creators: name: Kuznetsova, Tatyana
name: Wang, Shuang-Yin
name: Nagesha Rao
name: Mandoli, Amit
name: Martens, Joost
name: Rother, Nils
name: Aartse, Aafke
name: Laszlo Groh
name: Janssen-Megens, Eva
name: Guoliang Li
name: Yijun Ruan
name: Logie, Colin
name: Stunnenberg, Hendrik
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Activated p65 induces de novo P300 depositions to latent genomic loci. (A) Pile-up heat map depicting the H3K4me1 and H3K4me3 signal around (±12 kb) all p65-bound promoters and DBSs. (B) Pile-up heat map depicting the p65 and P300 signal at all p65-bound enhancers upon vehicle, DMSO (−), and TNFα (+) treatment. (C) Example screenshot depicting TNFα-induced P300 recruitment at genomic regions (red box) and recruitment of p65 at genomic loci that are pre-marked by P300. (D) Motif occurrence at all p65-bound DBS presented as a function of TNFα-dependent P300 recruitment (x-axis) (top-panel). Level of shared binding of p65 and other TFs at all p65-bound DBS, presented as a function of TNFα-dependent P300 recruitment (bottom panel). (E) Level of H3K27ac, DNase I hypersensitivity, and H3K4me1 at all p65-bound DBSs (induced and constitutive P300 sites). (PDF 909 kb)
GRAF VA DARAXTLAR BILAN BOGʻLIQ AYRIM MASALALARNI HAL QILISHDA BFS ALGORITMIDAN FOYDALANISH
Creators: name: Farmonov, Sherzodbek
name: Abdumutalova, Husnida
Publisher: name: Zenodo
Year: 2024

description: BFS (Breadth-First Search) algoritmi graf va daraxtlar kabi ma'lumot tuzilmalarida keng qo'llaniladigan samarali qidiruv algoritmidir. U kenglik bo'yicha qidiruvni amalga oshiradi, bu esa algoritmga eng qisqa yo'lni topish va bog'lanishlarni aniqlash imkonini beradi. BFS navbat (queue) ma'lumot tuzilmasidan foydalanadi va grafdagi barcha tugunlarni birma-bir tekshiradi. Algoritm eng qisqa yo‘lni topishda samaralidir.
Finite-size effects in hyperuniform vortex matter
Creators: name: Besana, Rocío Milagros
name: Elías, Federico
name: Puig, Joaquín
name: Sánchez, Jazmín Aragón
name: Nieva, Gladys
name: Kolton, Alejandro Benedykt
name: Fasano, Yanina
Publisher: name: arXiv
Year: 2024
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Novel hyperuniform materials are emerging as an active field of applied and basic research since they can be designed to have exceptional physical properties. This ubiquitous state of matter presents a hidden order that is characterized by the density of constituents of the system being uniform at large scales, as in a perfect crystal, although they can be isotropic and disordered like a liquid. In the quest for synthesizing hyperuniform materials in experimental conditions, the impact of finite-size effects remains as an open question to be addressed. We use vortex matter in type-II superconductors as a toy model system to study this issue. We previously reported that vortex matter nucleated in samples with point disorder is effectively hyperuniform and thus presents the interesting physical properties inherent to hyperuniform systems. In this work we present experimental evidence that on decreasing the thickness of the vortex system its hyperuniform order is depleted. By means of hydrodynamic arguments we show that the experimentally observed depletion can be associated to two crossovers that we describe within a hydrodynamic approximation. The first crossover length is thickness-dependent and separates a class-II hyperuniform regime at intermediate lengthscales from a regime that can become asymptotically non-hyperuniform for large wavelengths in very thin samples. The second crossover takes place at smaller lengthscales and marks the onset of a faster increase of density fluctuations due to the dispersivity of the elastic constants. Our work points to a novel mechanism of emerging hyperuniformity controlled by the thickness of the host sample, an issue that has to be taken into account when growing hyperuniform structures for technological applications.
description: 5 figures
Additional file 6: of Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
Creators: name: Kuznetsova, Tatyana
name: Wang, Shuang-Yin
name: Nagesha Rao
name: Mandoli, Amit
name: Martens, Joost
name: Rother, Nils
name: Aartse, Aafke
name: Laszlo Groh
name: Janssen-Megens, Eva
name: Guoliang Li
name: Yijun Ruan
name: Logie, Colin
name: Stunnenberg, Hendrik
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary text and Supplementary references. Cross-talk between GR and NFÎşB leads to complex changes in chromatin landscape. (DOCX 73 kb)
MOESM2 of
                     HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Creators: name: Xue, Feng
name: Higgs, Brandon
name: Jiaqi Huang
name: Morehouse, Chris
name: Zhu, Wei
name: Yao, Xin
name: Brohawn, Philip
name: Xiao, Zhan
name: Yinong Sebastian
name: Liu, Zheng
name: Xia, Yun
name: Shen, Dong
name: Kuziora, Mike
name: Zhengwei Dong
name: Hulin Han
name: Gu, Yi
name: Jianren Gu
name: Xia, Qiang
name: Yihong Yao
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Additional file 2. Supplementary Figures.
Additional file 1: of Translation and validation of the simplified Chinese new Knee Society Scoring System
Creators: name: Denghui Liu
name: Xiaokang He
name: Zheng, Wei
name: Zhang, Yu
name: Dahe Li
name: Wang, Wei
name: J. Li
name: Weidong Xu
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Computational Biology

description: Simplified Chinese version of SC-NKSS. (PDF 584Â kb)
Additional file 2: of Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells
Creators: name: Tao, Yi-Jing
name: Li, Yong-Ju
name: Zheng, Wen
name: Zhao, Juan-Juan
name: Guo, Meng-Meng
name: Zhou, Ya
name: Na-Lin Qin
name: Zheng, Jing
name: Xu, Lin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Figure S2. The effect of miR-21 ASO on the growth of human colon carcinoma cell line SW620 cells in vitro. Human colon carcinoma cell line SW620 cells were transiently transfected with p-miR-21-ASO or p-Cont (5 μg). (A) 48 h later, the relative expression of miR-21 was analyzed by real-time PCR assay. (B) The growth of cells was determined by CCK-8 assay at indicated tie point. One representative of three experiments is shown. *p
Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas
Creators: name: Weber, Florian
name: Junger, Henrik
name: Werner, Jens M.
name: Vélez Char, Natalia
name: Rejas, Carolina
name: Schlitt, Hans J.
name: Hornung, Matthias
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: INVARIANT NKT CELLS; LYMPHOCYTIC INFILTRATION; INDUCIBLE PROTEIN-10; ANTIGEN PRESENTATION; T-CELLS; MICROENVIRONMENT; RECOGNITION; ASSOCIATION; METASTASES; MANAGEMENT; CD1d; immunotherapy; lymphocyte infiltration; NKT cell; thyroid carcinoma
subject: 610 Medizin

description: Background Anaplastic thyroid carcinomas are associated with rapid tumor growth, short survival time and without any promising therapy to improve the poor prognosis. In this study, expression of immunoregulative receptor CD1d and lymphocyte infiltration in different thyroid tumors as well as in healthy tissue were analyzed in order to find new targets for an immunotherapeutic approach. Methods CD1d immunohistochemistry was performed in samples of 18 anaplastic, 17 follicular, 27 papillary, and 4 medullary thyroid carcinomas as well as in 19 specimens from normal thyroid tissue and additionally in 10 samples of sarcoma, seven malignant melanoma and three spindle-cell lung carcinoma. Furthermore, thyroid samples were stained with antibodies against CD3, CD20, CD56, CD68, and LCA in order to analyze lymphocyte infiltration. Results For the first time CD1d receptor expression on normal thyroid tissue could be demonstrated. Moreover, anaplastic thyroid carcinomas showed significantly higher expression levels compared to other thyroid samples. Most astonishingly, CD1d expression disappeared from the cellular surface and was detected rather in the cytoplasm of anaplastic thyroid carcinoma cells. In addition, histologically similar tumors to anaplastic carcinoma like sarcoma and malignant melanoma revealed distinct CD1d staining patterns. Furthermore, infiltration of T cells, B cells, and macrophages in anaplastic thyroid carcinomas was different when compared to normal thyroid tissue and all other thyroid carcinomas. Conclusions Anaplastic thyroid carcinomas show significantly higher expression of CD1d, a receptor for NKT cells, which are subject of several anticancer therapy studies. These results may offer a novel approach to explore immunotherapeutic treatment options.
Additional file 1: of Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells
Creators: name: Tao, Yi-Jing
name: Li, Yong-Ju
name: Zheng, Wen
name: Zhao, Juan-Juan
name: Guo, Meng-Meng
name: Zhou, Ya
name: Na-Lin Qin
name: Zheng, Jing
name: Xu, Lin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology

description: Figure S1. The relative expression of miR-21 in colon carcinoma cells. Three human colon carcinoma cells and normal colonic cells FHC were culture in 96-well plate. Then, the relative expression of miR-21 was determined by real-time PCR assay. *pÂ
Culture conditions matter: how A549 morphology differs in submerged or air-liquid interface culture systems
Creators: name: Michelini, Sara
name: Kurešepi, Ema
name: Repar, Neza
name: Šimunović, Katarina
name: Mandić Mulec, Ines
name: Erman, Andreja
name: Drobne, Damjana
Publisher: name: Zenodo
Year: 2024

description: One of the main routes of exposure to Micro- and Nanoplastics (MNPs) is through inhalation, and studies have already reported that they can cause occupational diseases. Therefore, it is of utmost importance to test the effects of MNPs on lung models. However, since the lung is a complex environment, short-term cytotoxicity tests performed on cells grown under standard submerged settings might not be indicative of real-life hazards. For this reason, we tested the impact of different culture systems (submerged (Sub) and air-liquid interface (ALI)) on the polarisation of A549 cells towards an alveolar type II (ATII)-like phenotype to determine the best, and more realistic setup to perform our future experiments with MNPs.
Agrilus planipennis Fairmaire 1888
Creators: name: Jendek, Eduard
name: Nakládal, Oto
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus planipennis

description: Agrilus planipennis Fairmaire, 1888
(Figs 5 A–5F, 6A–6D)
Examined specimens. CHINA. Beijing. Badalingzhen env.; 40°21'43"N, 115°55'57"E; 6-2016; alt. 600 m; 1 (EJCB) // Xiaolongmen Nat. Park; 39°57'53"N, 115°26'07"E; 6-2016; alt. 1000–1300 m; 1 ♂, 1 ♀ (EJCB). Jilin. Dashi, 40 km SE Jilin city; 43°33'46"N, 126°51'E; 6-2017; alt. 350 m; 1 (EJCB) // Erdaozun; 42°25'54"N, 128°06'50"E; 7-2017; alt. 700 m; Larval host: Fraxinus; 10 (EJCB) // Jiaohe env., 95 km NEE Jilin; 43°57'N, 127°42'E; 6, 7-2017; alt. 400–600 m; Larval host: Fraxinus; 14 (EJCB) // Jiaohe, Pingdigoucun env.; 43°57'35"N, 127°41'38"E; 6, 7-2015; 2 (BUJC) // Jilin city, Songhua river; 43°47'16"N, 126°34'30"E; 6-2017; alt. 200 m; Larval host: Fraxinus; 3 (EJCB).
Host plant cited. Larval: Fraxinus.
Biological remarks. During the visit of senior author in China in 2016–2017, the massive outbreak of A. planipennis was observed in Badalingzhen (Beijing, China) on Fraxinus velutina (Figs 5 A–5B) in 2016, and a year later, virtually all visited sites in Jilin province (Jilin City, Erdaozun, Jiaohe) with planted Fraxinus in urban areas were heavily infested (Figs 5D, 5F, 6 A–6D). Additionally, the couple of adults and galleries of A. planipennis were found in the Xiaolongmen National Park in Beijing province in the native habitat and on the native Fraxinus. Galleries (Figs 5C, 5E) bored by a single larva in living branches of smaller diameter (5–10 cm) were found on younger or shrubby ashes. Infested branches dried, but no tree mortality was observed.
description: Published as part of Jendek, Eduard & Nakládal, Oto, 2019, Taxonomic, distributional and biological study of the genus Agrilus (Coleoptera: Buprestidae). Part II, pp. 401-459 in Zootaxa 4554 (2) on page 433, DOI: 10.11646/zootaxa.4554.2.5, http://zenodo.org/record/2623782
Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
Creators: name: Anssar, Tareq M.
name: Leitzmann, Michael F.
name: Linker, Ralf A.
name: Meier, Christoph
name: Becker, Claudia
name: Jick, Susan
name: Sahm, Katharina
name: Platten, Michael
name: Hau, Peter
name: Seliger, Corinna
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: REGULATORY T-CELLS; BRAIN-TUMORS; ALLERGIC CONDITIONS; TRANSPLANT RECIPIENTS; IMMUNOGLOBULIN-E; IGE LEVELS; CANCER; GLIOBLASTOMA; MENINGIOMA; MICROBIOTA; autoimmune diseases; glioma; immunosuppressive therapies
subject: 610 Medizin

description: Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune-surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well-validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune-related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86-1.11), allergy (OR 0.97, 95% CI 0.89-1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31-5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58-0.91) and between long-term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53-0.96).
XMM-NuSTAR Observation and Multiwavelength SED Modeling of Blazar 4FGL J1520.8-0348
Creators: name: Rajguru, Garima
name: Marcotulli, L.
name: Ajello, M.
name: Tramacere, A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Active galactic nuclei (AGNs) can power relativistic jets, which are called blazars when pointed close to our line of sight. Depending on the presence or absence of emission lines in their optical spectra, blazars are categorized into flat spectrum radio quasars (FSRQs) or BL Lacertae (BL Lacs) objects. According to the 'blazar sequence', as synchrotron peak frequency ($ν^{sy}_{pk}$) shifts to higher energies, the synchrotron peak luminosity decreases. This means that BL Lacs as luminous as FSRQs, and with synchrotron peak frequencies $ν^{sy}_{pk}>10^{15}$ Hz, should not exist. Detected as a high-synchrotron peak (HSP; $ν^{sy}_{pk}>10^{15}$ Hz) BL Lac, 4FGL J1520.8-0348 shows high gamma-ray luminosity ($L_γ>10^{46}\,\rm erg~s^{-1}$), being at a high redshift of $z=$1.46. Since it is an outlier in the 'blazar sequence', the process of its jet acceleration and power may be different from bona fide BL Lacs. In this work, we constrain its spectral energy distribution (SED) by modeling the multi-wavelength data from infrared to $γ$-ray regime. Simultaneous X-ray data was obtained from X-ray Multi-Mirror Mission and Nuclear Spectroscopic Telescope Array to constrain the synchrotron emission and underlying electron distribution. On undertaking the SED modeling of the source, including the effect of extragalactic background light, we conclude that the source is more likely to be a 'blue FSRQ' or 'masquerading BL Lac' where the BL Lac is actually a FSRQ in disguise.
Agrilus politus
Creators: name: Jendek, Eduard
name: Nakládal, Oto
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus politus

description: Agrilus politus (Say, 1825)
Figs 7 A–7D
Examined specimens. CANADA. Quebec. Pontiac-Luskville, Gatineau Park; 45°32'18"N, 076°00'26"W; 6-2008; Larval host: Salix; 50 (EJCB).
Host plant cited. Larval: Salix.
Biological remarks. North American Agrilus politus (Figs 7 A–7D) have biology very similar to European A. viridis (Fig. 10C) on Salix.
description: Published as part of Jendek, Eduard & Nakládal, Oto, 2019, Taxonomic, distributional and biological study of the genus Agrilus (Coleoptera: Buprestidae). Part II, pp. 401-459 in Zootaxa 4554 (2) on page 437, DOI: 10.11646/zootaxa.4554.2.5, http://zenodo.org/record/2623782
Signatures of the accelerating black holes with a cosmological constant from the $\textrm{Sgr~A}^\star$ and $\textrm{M87}^\star$ shadow prospects
Creators: name: Chakhchi, L.
name: Moumni, H. El
name: Masmar, K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, the Event Horizon Telescope (EHT) achieved the realization of an image of the supermassive black hole $\textrm{Sgr~A}^\star$ showing an angular shadow diameter $\mathcal{D}= 48.7 \pm 7μas$ and the fractional deviation $\mathbfδ = -0.08^{+0.09}_{-0.09}~\text{(VLTI)},-0.04^{+0.09}_{-0.10}~\text{(Keck)}$, alongside the earlier image of $\textrm{M87}^\star$ with angular diameter $ \mathcal{D}=42 \pm 3 μas$, deviation $\mathbfδ=-0.01^{+0.17}_{-0.17}$ and deviations from circularity estimated to be $Δ\mathcal{C}\lesssim 10\%$. In addition, the shadow radii are assessed within the ranges $3.38 \le \frac{r_{\text{s}}}{M} \le 6.91$ for $\textrm{M87}^\star$ and $3.85 \le \frac{r_{\text{s}}}{M} \le 5.72$ as well as $3.95 \le \frac{r_{\text{s}}}{M} \le 5.92$ for $\textrm{Sgr~A}^\star$ using the Very Large Telescope Interferometer (VLTI) and Keck observatories, respectively. These values are provided with $1$-$σ$ and $2$-$σ$ measurements. Such realizations can unveil a better comprehension of gravitational physics at the horizon scale. In this paper, we use the EHT observational results for $\textrm{M87}^\star$ and $\textrm{Sgr~A}^\star$ to elaborate the constraints on parameters of accelerating black holes with a cosmological constant. Concretely, we utilize the mass and distance of both black holes to derive the observables associated with the accelerating black hole shadow. First, we compare our findings with observed quantities such as angular diameter, circularity, shadow radius, and the fractional deviation from the $\textrm{M87}^\star$ data. This comparison reveals constraints within the acceleration parameter and the cosmological constant...
 Lastly, one cannot rule out the possibility of the negative values for the cosmological constant on the emergence of accelerated black hole solutions within the context of minimal gauged supergravity...
description: 37 pages, 10 figures, references updated
Endodontic regeneration - hard shell, soft core
Creators: name: Widbiller, Matthias
name: Schmalz, Gottfried
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: Dentin; Pulp; Regeneration; Tissue engineering; Regenerative medicine
subject: 610 Medizin

description: A loss of organs or the destruction of tissue leaves wounds to which organisms and living things react differently. Their response depends on the extent of damage, the functional impairment and the biological potential of the organism. Some can completely regenerate lost body parts or tissues, whereas others react by forming scars in the sense of a tissue repair. Overall, the regenerative capacities of the human body are limited and only a few tissues are fully restored when injured. Dental tissues may suffer severe damage due to various influences such as caries or trauma; however, dental care aims at preserving unharmed structures and, thus, the functionality of the teeth. The dentin-pulp complex, a vital compound tissue that is enclosed by enamel, holds many important functions and is particularly worth protecting. It reacts physiologically to deleterious impacts with an interplay of regenerative and reparative processes to ensure its functionality and facilitate healing. While there were initially no biological treatment options available for the irreversible destruction of dentin or pulp, many promising approaches for endodontic regeneration based on the principles of tissue engineering have been developed in recent years. This review describes the regenerative and reparative processes of the dentin-pulp complex as well as the morphological criteria of possible healing results. Furthermore, it summarizes the current knowledge on tissue engineering of dentin and pulp, and potential future developments in this thriving field.
Carex lehmanniana Boott
Creators: name: Lois, Raúl
name: Acedo, Carmen
name: Reznicek, Anton A.
name: Jiménez-Mejías, Pedro
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Carex
Carex lehmanniana

description: Typification of Carex lehmanniana Boott Proc. Linn. Soc. London 1: 256 (1845)
The taxonomy and nomenclature of Carex sect. Fecundae is difficult and still remains uncertain. During the revision of this section we found out that the name Carex lehmanniana Boott has not been typified yet. Therefore, a lectotype is designated below.
Carex lehmanniana Boott [‘ lemanniana ’], Proc. Linn. Soc. London 1: 256 (1845)
Ind. loc.: “in locis humidis Montis ignivomi Cotopaxi Columbiae [Hartweg’s collection] […]; Columbia [Ecuador] [Jameson’s collection; no further indication provided]”.
Lectotype (here designated): — ECUADOR, Province of Cotopaxi. Volcán Cotopaxi “ Hartweg 1446 ” (K-000584603 photo! Fig. 13; isolectotypes P!, E-00502225, photo!; NY-00011464, photo!).
Observations:— The name was originally published as “ Carex lemanniana ” that Boott (1845: 256) dedicated to C.M. Lehmann, in whose personal herbarium he studied the specimens quoted in the protologue. Boott wrote the name as “Lemann”. After that, the name and description of the species was transcribed again by Boott (1846: 121). The name was later corrected as “ Carex lehmanniana ” (Walpers 1849: 910). This is a case of an orthographic correction following ICN Art. 60.1 (ICN; Turland et al., 2018), not a publication of the name nor description as appeared in some databases such as tropicos.org (2021) and International Plant Names Index (IPNI, 2021).
Although the indications of Boott’s in the protologue and the manuscript in the sheet, located the specimens in Colombia (Columbiae), actually the volcano Cotopaxi (Montis ignivomi Cotopaxi) belongs to Ecuador. It must take into account the situation of Ecuador as a department of Great Colombia until 1831, even though the original description is dated in 1845.
description: Published as part of Lois, Raúl, Acedo, Carmen, Reznicek, Anton A. & Jiménez-Mejías, Pedro, 2023, Three newly described species of Carex sect. Fecundae (Cyperaceae) from Central America and typification of two related names, pp. 71-86 in Phytotaxa 579 (2) on page 85, DOI: 10.11646/phytotaxa.579.2.1, http://zenodo.org/record/7543084
Towards Two-Stream Foveation-based Active Vision Learning
Creators: name: Ibrayev, Timur
name: Mukherjee, Amitangshu
name: Aketi, Sai Aparna
name: Roy, Kaushik
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Deep neural network (DNN) based machine perception frameworks process the entire input in a one-shot manner to provide answers to both "what object is being observed" and "where it is located". In contrast, the "two-stream hypothesis" from neuroscience explains the neural processing in the human visual cortex as an active vision system that utilizes two separate regions of the brain to answer the what and the where questions. In this work, we propose a machine learning framework inspired by the "two-stream hypothesis" and explore the potential benefits that it offers. Specifically, the proposed framework models the following mechanisms: 1) ventral (what) stream focusing on the input regions perceived by the fovea part of an eye (foveation), 2) dorsal (where) stream providing visual guidance, and 3) iterative processing of the two streams to calibrate visual focus and process the sequence of focused image patches. The training of the proposed framework is accomplished by label-based DNN training for the ventral stream model and reinforcement learning for the dorsal stream model. We show that the two-stream foveation-based learning is applicable to the challenging task of weakly-supervised object localization (WSOL), where the training data is limited to the object class or its attributes. The framework is capable of both predicting the properties of an object and successfully localizing it by predicting its bounding box. We also show that, due to the independent nature of the two streams, the dorsal model can be applied on its own to unseen images to localize objects from different datasets.
description: Accepted version of the article, 18 pages, 14 figures
Evaluating Single Event Upsets in Deep Neural Networks for Semantic Segmentation: an embedded system perspective
Creators: name: Gutiérrez-Zaballa, Jon
name: Basterretxea, Koldo
name: Echanobe, Javier
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Hardware Architecture (cs.AR)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: As the deployment of artifical intelligence (AI) algorithms at edge devices becomes increasingly prevalent, enhancing the robustness and reliability of autonomous AI-based perception and decision systems is becoming as relevant as precision and performance, especially in applications areas considered safety-critical such as autonomous driving and aerospace. This paper delves into the robustness assessment in embedded Deep Neural Networks (DNNs), particularly focusing on the impact of parameter perturbations produced by single event upsets (SEUs) on convolutional neural networks (CNN) for image semantic segmentation. By scrutinizing the layer-by-layer and bit-by-bit sensitivity of various encoder-decoder models to soft errors, this study thoroughly investigates the vulnerability of segmentation DNNs to SEUs and evaluates the consequences of techniques like model pruning and parameter quantization on the robustness of compressed models aimed at embedded implementations. The findings offer valuable insights into the mechanisms underlying SEU-induced failures that allow for evaluating the robustness of DNNs once trained in advance. Moreover, based on the collected data, we propose a set of practical lightweight error mitigation techniques with no memory or computational cost suitable for resource-constrained deployments. The code used to perform the fault injection (FI) campaign is available at https://github.com/jonGuti13/TensorFI2 , while the code to implement proposed techniques is available at https://github.com/jonGuti13/parameterProtection .