Additional file 1 of Colon cancer survival differs from right side to left side and lymph node harvest number matter
Creators: name: Mangone, Lucia
name: Pinto, Carmine
name: Mancuso, Pamela
name: Ottone, Marta
name: Bisceglia, Isabella
name: Chiaranda, Giorgio
name: Michiara, Maria
name: Vicentini, Massimo
name: Carrozzi, Giuliano
name: Ferretti, Stefano
name: Falcini, Fabio
name: Hassan, Cesare
name: Rossi, Paolo Giorgi
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Person years, number of deaths and censored (moved out of the cancer registry area) by cancer site, patient, and cancer characteristics. Incident colon cancer cases, Emilia-Romagna, Italy, 2000-2012, follow up to December 31, 2017. Supplementary Figure 1. Directed acyclic graph of the putative causal pathway linking colon cancer site with cancer survival. Supplementary Figure 2. Directed acyclic graph of the putative causal pathway linking number of removed lymph nodes in colon cancer surgery with cancer survival. Supplementary Figure 3. Log-log plot of survival by colon cancer side. Curves are constantly parallel after the first month of follow up, i.e., ln -2.5years of follow up. Supplementary Figure 4. Comparison of the observed Kaplan–Meier survival curves and Cox proportional hazard predicted survival curves. For all three groups (right, left, and transvers), observed and predicted curves substantially overlap. Supplementary Figure 5. Plots of Martingale residuals computed for age. The plot of Martingale residuals is random, showing no systematic patterns or trends, and the LOESS smoothed curve appears to lie around a horizontal line through zero, supporting the linear component of the age variable correctly describing the effect of age on survival. Supplementary Figure 6. Log-log plot of survival curves by number of lymph nodes, right-sided cancers. Curves are constantly parallel throughout follow up. Supplementary Figure 7. Comparison of the observed Kaplan–Meier survival curves and Cox proportional hazard predicted survival curves, right-sided cancers. For all the three groups (&lt;12, 12-21, &gt;21 removed lymph nodes), observed and predicted curves substantially overlap. Supplementary Figure 8. Log-log plot of survival curves by number of lymph nodes, left-sided cancers. Curves are constantly parallel throughout follow up. Supplementary Figure 9. Comparison of the observed Kaplan–Meier survival curves and Cox proportional hazard predicted survival curves, left-sided cancers. For all the three groups (&lt;12, 12-21, &gt;21 removed lymph nodes), observed and predicted curves substantially overlap. Supplementary Table 2. Multivariable Cox proportional hazard model reporting hazard ratios for cancer site adjusted for age, sex, screening status, stage, and grade. Incident colon cancer cases, Emilia-Romagna, Italy, 2000-2012, follow up until December 31, 2017. Number of observations=8,327. Supplementary Table 3. Multivariable Cox proportional hazard model reporting hazard ratios for cancer site adjusted for age, sex, screening status, stage, grade, and number of removed lymph nodes. Incident colon cancer cases, Emilia-Romagna, Italy, 2000-2012, follow up until December 31, 2017. Number of observations=8,274. Supplementary Figure 10. Definition of left and right colon as reported in recently published studies.