cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Inhibition of TC-83 Alphavirus by Small Molecule Saracatinib and Piscidin Peptide Candidates
Creators: name: Green, Leykie I.
Publisher: name: George Mason University
Year: 2024
Subjects: subject: Saracatinib
subject: TC-83
subject: Piscidin peptides
subject: Inhibition
subject: Central nervous system
subject: antiviral

description: Venezuelan Equine Encephalitis Virus (VEEV) is an encephalitic alphavirus that is known to cause disease in the central nervous system (CNS). It is naturally transmitted by infected mosquitoes and causes disease in equines and humans on a regular basis in various parts of the world. VEEV also has the potential to be aerosolized, and when infection is acquired via the respiratory route, the chances of CNS penetration are higher, with increased incidences of morbidity and mortality. Even if infected individuals clear the infection, there is a potential for long term neurological sequelae in survivors, thus increasing the disease burden. There are currently no FDA-approved therapeutic intervention strategies to treat the encephalitic manifestations of VEEV infection-induced disease. This thesis project focused on establishing early stage efficacy measurements for a candidate small molecule inhibitor, Saracatinib, which is already FDA-approved for the treatment of cancer. In addition, this project also involved screening a small library of synthetic antimicrobial peptides (AMPs) derived from a parent piscidin peptide. Piscidins are fish-derived, naturally occurring AMPs that have been demonstrated to have antibacterial and immunomodulatory properties. My project was based on the hypothesis that Saracatinib and synthetic piscidin-derived AMPs will demonstrate antiviral activities against VEEV. This project was performed using the attenuated TC-83 strain of VEEV, in the context of several human-derived cell lines of the blood brain barrier (BBB). Analysis of antiviral activities of Saracatinib in the nontoxic range demonstrated that endothelial cells were highly responsive to treatment and showed significant reduction in viral load in treated cells. Screening of the synthetic piscidin library has identified four candidates that showed a statistically significant reduction in viral load in a human astrocyte cell line. Cumulatively, these data provide the foundation for further development of Saracatinib and prioritized synthetic piscidin AMPs as therapeutic intervention strategies against VEEV infection.
title: Correspondence: W.K. Cunningham, Jr. and C. Harrison Mann, Jr., August 11, 1967-August 15, 1967
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
name: Cunningham, W.K.
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Civil unrest
subject: Brown, Rap

description: Letter A: 2 pgs, typescript signed, 8.5" x 11" (21.6cm x 27.9cm); Letter B: 1 pg, typescript unsigned, 8.5" x 11" (21.6cm x 27.9cm)
description: Correspodence between W.K. Cunningham, Jr., Director of the Virginia Division of Corrections, and C. Harrison Mann, Jr. regarding the need to house potential prisoners should there be civil unrest during the extridition of Rap Brown, a civil rights activist. C. Harrison Mann, Jr. Collection 18.01A
Report On The Training Needs Identified Across The Elixir Community
Creators: name: Gelder, Celia Van
name: Morgan, Sarah
name: Via, Allegra
name: Hendricusdottir, Rita
name: Korpelainen, Eija
name: Ponting, Chris
name: Attwood, Terri
name: Palagi, Patricia
Publisher: name: Zenodo
Year: 2016
Subjects: bioinformatics
training

description: With this deliverable, we report on the efforts undertaken since 2014, and in particular since the start of the ELIXIR-EXCELERATE project, by the ELIXIR Training Platform regarding the identification of training needs in ELIXIR, the actions that were carried out to fulfill these needs, and outlines our plans for the years ahead.

ELIXIR Training has identified three major target audiences: infrastructure users,

infrastructure developers, and trainers. Several activities have already been provided for these groups in project year 1 and many more are planned for project year 2 to 4.

Through the identification of priorities for ELIXIR’s Training Platform, via Node surveys (2014) and through dedicated liaison persons, we were able to start addressing the critical training deficits important for these three groups - including members from academia as well as industry - across Europe. ELIXIR Training activities include workshops in the areas of Software or Data Carpentry, High-Performance Computing, Workflow Tools, Data Management and Stewardship, and Train-the-Trainer courses in which expert staff learn techniques and tools for teaching bioinformatics.
title: Entry form: Charles D. McGuire, 1988/89
Creators: name: McGuire, Charles D.
Publisher: name: George Mason University
Year: 2006
Subjects: subject: All-America Cities
subject: Reston (Va.)

description: Entry form: typed answers taped to entry form, 11" x 8.5" (29.7cm x 21.6cm)
description: Official Entry Form for the All-America City Award for Citizen, Action, Effective Organization, and Community Improvement and sponsored by the National Civic League. This entry form was submitted in 1988 and again in 1989 to demonstrate Reston's continuing excellence in community achievements. The entry form questions Reston's rise from rural farms to a booming urban center; current civic projects, the reasons for specific action and any obstacles in achieving the goals for the Homeless Shelter, Town Hall Preservation, and local OB Unit; principal civic groups and organizations operating in Reston and their participation in the projects listed previously; and other factors contributing to the success of the community. See also Letter from Charles D. McGuire to All-America City Program, 31 March 1989. Planned Communitiy Archives Collection, 443.13.
title: Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa
Creators: name: Ulrey, Robert K.
name: Barksdale, Stephanie M.
name: Zhou, Weidong
name: Van Hoek, Monique L.
Publisher: name: BioMed Central
Year: 2014
Subjects: subject: Cranberry
subject: Proanthocyanidins
subject: Pseudomonas aeruginosa
subject: Biofilm

description: Background Bacteria within a biofilm are phenotypically more resistant to antibiotics, desiccation, and the host immune system, making it an important virulence factor for many microbes. Cranberry juice has long been used to prevent infections of the urinary tract, which are often related to biofilm formation. Recent studies have found that the A-type proanthocyanidins from cranberries have anti-biofilm properties against Escherichia coli. Methods Using crystal violet biofilm staining, resazurin metabolism assays, and confocal imaging, we examined the ability of A-type proanthocyanidins (PACs) to disrupt the biofilm formation of Pseudomonas aeruginosa. We used mass spectrometry to analyze the proteomic effects of PAC treatment. We also performed synergy assays and in vitro and in vivo infections to determine whether PACs, alone and in combination with gentamicin, could contribute to the killing of P. aeruginosa and the survival of cell lines and G. mellonella. Results Cranberry PACs reduced P. aeruginosa swarming motility. Cranberry PACs significantly disrupted the biofilm formation of P. aeruginosa. Proteomics analysis revealed significantly different proteins expressed following PAC treatment. In addition, we found that PACs potentiated the antibiotic activity of gentamicin in an in vivo model of infection using G. mellonella. Conclusions Results suggest that A-type proanthocyanidins may be a useful therapeutic against the biofilm-mediated infections caused by P. aeruginosa and should be further tested.
Supplementary document for Dynamics of single cell femtosecond laser printing - 6363596.pdf
Creators: name: Zhang, Jun
name: Frank, Christine
name: Byers, Patrick
name: Djordjevic, Sasa
name: Docheva, Denitsa
name: Clausen-Schaumann, Hauke
name: Sudhop, Stefanie
name: Huber, Heinz
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Fluid Physics

description: Supplemental Document
Estimation of standing crop biomass in rangelands of the Middle Atlas mountains using remote sensing data
Creators: name: Boukrouh, S
name: Bouazzaoui, Y
name: Aich, A El
name: Mahyou, H
name: Chikhaoui, M
name: Lafkih, M Ait
name: N’Dorma, O
name: Alados, CL
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: In the Middle Atlas rangelands, traditional methods for estimating standing crop biomass are labour-intensive and impractical. Remote sensing offers an initiative for standing crop biomass large-scale monitoring. The aim of this study was to estimate standing crop biomass, comprising annual and perennial forbs, grasses and perennial shrubs, using remote sensing data. The vegetation indices (NDVI, DVI, RVI, MSAVI and OSAVI) were derived from medium-resolution Landsat 8 and MODIS imagery. Sixty sampling sites were used for the biomass data collection. These sites were located across three grazing areas and data were collected in May and June 2016. Regression models were established between biomass field data and the five indices. Correlation analysis indicated that among the five vegetation indices, only DVI had the lowest value (r = 0.60). Linear models developed between the biomass field data and vegetation indices showed that NDVI, OSAVI and RVI explained a reasonable percentage of the variance in biomass. Values for R2 were 0.74, 0.77 and 0.71, respectively. Among these indices, the OSAVI performed better, with a high R2 and low error (MAPE = 11.03%). The established models represent a key tool for long-term monitoring of these rangelands.
title: Why Conferences Matter—An Illustration from the International Marine Conservation Congress
Creators: name: Oester, Samantha
name: Cigliano, John A.
name: Hind-Ozan, Edward J.
name: Parsons, E. Christien Michael
Publisher: name: Frontiers in Marine Science
Year: 2017

description: A major activity in the life of an academic is the professional conference. It is common knowledge that this is a place to present your research, but what about other benefits of attending a conference? Online surveys were distributed to delegates of the 3rd and 4th International Marine Conservation Congresses (IMCCs), with respondents' (n = 100) feedback including that the congresses provided useful new information that will aid: (1) their research (58%); (2) in-the-field conservation (29%); (3) conservation communication (46%); and (4) conservation and management policy making (45%). They also reported gaining new techniques (56%), skills (64%), and novel ideas (70%) to further their research/careers. Nearly all (91%) gained new contacts that improved their research, in-the-field conservation, science communication, and/or conservation policy making. Two thirds (64%) gained ideas, contacts, and/or lessons could lead to publications. Over a third (39%) gained new ideas, contacts and/or lessons that led to grant proposals, and 36% gained contacts that led to funding. A conference is not just an avenue for a scientist to present their research to the wider community, but it can be an important venue for brainstorming, networking and making vital connections that can lead to new initiatives, papers and funding, in a way that virtual, online meetings cannot. This is why conferences matter.
title: Bylaws: Community Development Corporation, Undated
Creators: name: Community Development Corporation
Publisher: name: George Mason University
Year: 2006
Subjects: subject: U.S. Department of Housing and Urban Development (HUD)

description: Textual: Bylaws, copy; 10.5” x 8” (25.4 cm x 21.6 cm)
description: Undated bylaws for the Community Development Corporation that are undated. These bylaws discuss the organization of the Community Development Corporation, a division of the Department of Housing and Urban Development. A resolution to amend these bylaws, as well as an edited set of bylaws calling for the renaming of Community Development Corporation to include the word "New" are also included. Planned Community Archives Collection, 484.01
title: Describing Political Regime Change from a Complex Systems Perspective
Creators: name: McFarlane, Hugh J.
Publisher: name: George Mason University
Year: 2012
Subjects: subject: Complex adaptive systems
subject: Complex social systems
subject: Political stability
subject: Punctuated equilibrium
subject: Regime change
subject: Self-organized criticality

description: Changes to the formal rules and institutions governing political activity are driven by the complex interactions between political actors seeking resources from the state. These changes disrupt the network of competitive-cooperative relationships that given sufficient time to mature help stabilize and reinforce persistence of the status quo. This thesis analyzes these dynamics from the perspective of complex systems theory. The principle finding is that the pressure to change regime characteristics moves through three distinct phases. Immediately following a change to regime characteristics, system dynamics are unstable, indicated by rising hazard force. Over time, the political system transitions to a stabilizing self-reinforcing dynamic. During this period a power law model describes the survival function and distribution of regime change magnitudes, while the hazard force decreases nonlinearly. During the final phase a rising hazard force indicates a transition to back to unstable equilibrium dynamics. These findings indicate that changes to regime characteristics are the result of system level interdependence that forms as a result of the development of tactics, strategies and relationships following a previous regime change. Those cases where regime characteristics survive for decades, even past the century mark as some autocratic and democratic states have managed are indicative of system success in developing equilibrium dynamics that effectively resist pressures to change.
Videos In Public Libraries: New Models Of Collaboration In Europe
Creators: name: Scheel, Tilman
Publisher: name: Zenodo
Year: 2016
Subjects: Video on Demand, Collaboration, Film, Public Libraries

description: Abstract:

Providing access to video can be challenging, especially when it comes to film. To clear the rights, to get hands on the material, to manage the licenses, different language versions and age ratings - all this needs to be solved before a film is shown to any kind of public. More often than not, public institutions do neither have the expertise, the personnel, the money or the experience to answer to this challenge.

The solution suggested by AVA – Audio Visual Access is collaboration. Film festivals, public libraries and a technology company with a focus on Video on Demand work together to provide festival films to public libraries and cultural institutions across Europe. The festivals select the films, curate programs, clear the rights and provide the video files and the institutions provide the space, visibility and the audience. The technology company is providing the services and solutions: In AVA we are creating a platform that allows all the different partners to work together on rights management, access for the audience, cloud transcoding, VoD, authentication services etc. etc.

Another aspect is worth mentioning: Money. Collaboration projects like AVA are proving very successful with funding institutions. AVA is being financed under the Audience Development call by the MEDIA program of the European Union. Another project run by the reelport GmbH on Virtual Reality with a similar consortium has been awarded funding by the H2020 program of the European Union, too.

In the light of this success of AVA we strongly encourage partnerships between everybody dealing with digital video, science and other public institutions, content providers and tech – companies alike.
title: Lachenalia :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants..,
Publisher: name: International Union for the Protection of New Varieties of Plants
Year: 0
Subjects: Lachenalia
Group identity.
New Varieties of Plants

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Titanium Dioxide Mediated Photocatalytic Degradation of Methylene Blue in a Fixed Film-Type Photoreactor
Creators: RamMohan, Gayathri
Rosenberger, Paul
Buxy, Samriddhi
Pullammanappallil, Pratap
Goswami, Tushar
Publisher: name: University of Alberta Library
Year: 2014

A novel, cost effective and reusable TiO2-coated nonwoven media was used to investigate the photocatalytic degradation of methylene blue (MB)-containing wastewater. A falling film-type photoreactor with recirculation was designed and operated inside a black box set up with provision for three 15 W UV 350 nm lamps. Photocatalytic experiments were conducted at an initial pH= 7 and 25 °C. Dye photodegradation was studied by the change in absorbance at 660 nm using a UV-Vis spectrophotometer. Time period of exposure, initial dye concentrations (5, 10, and 15 mg/L), and mixing were investigated. More than 95% decolorization was obtained within 4, 5, and 9 h for 5, 10, and 15 mg/L of dye-containing wastewater, respectively. Results were compared with experiments using TiO2-powdered catalysts.
title: COMPUTATIONAL IDENTIFICATION OF VIRAL/BACTERIAL EPITOPES FOR TYPE AND STRAIN CHARACTERIZATION, LEADING TO THE DEVELOPMENT OF VACCINES AGAINST HUMAN ADENOVIRUS, HIV, AND STAPHYLOCOCCUS AUREUS
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: Identifying newly isolated adenovirus is important to the understanding of pathogens and molecular evolution. With the advancement of sequencing technology, virus sequences are accumulated. New genotypes emerge due to recombination in capsid proteins, penton base, hexon, and fiber. A rapid identification of newly emerging genotypes became necessary for current HAdV scientists, and a software tool was developed to accurately identify and characterize the genotypes based on recombination. The genotyping tool characterizes newly emergent adenoviruses by identifying the type-specific epitopes and complementing them with the referencing database. The genotyping outcomes are based on BLAST results, phylogenetic trees, and sequence identity with the pre-existing epitopes. The performance of the genotyping was tested on 52 human adenovirus genotype sequences, resulting in 100% sensitivity and specificity. Genotyping enables quick and accurate detection of novel strains. Staphylococcus aureus is the leading cause of skin and soft tissue infections worldwide. Strain identification is critical for understanding the epidemiology of this pathogen. The highly variable spa gene provides a sensitive method for distinguishing S. aureus isolates. The spa gene product is a surface antigen with Ig-binding activity that is involved in immune evasion. Spa includes a variable Xr region that has multiple repeats, usually 8 amino acids in length. Repeats within an Xr region may have different amino acid sequences. Over 19,817 variants of the spa gene are known to date. Combined with other methods such as multilocus sequence typing, spa typing can provide high resolution strain identification. This is an open-source spa typing program that: requires no helper applications; it can be integrated into bioinformatics pipelines and can analyze complete draft genome sequences.
МЕТОДИКА ПРЕПОДАВАНИЯ РУССКОГО ЯЗЫКА В ШКОЛЕ: СОВРЕМЕННЫЕ ПОДХОДЫ И ЭФФЕКТИВНЫЕ МЕТОДЫ
Creators: name: Янгибаева, Гулнара
Publisher: name: Zenodo
Year: 2025

description: В данной работе рассматриваются современные подходы к методике преподавания русского языка в школе. Подчёркивается важность формирования коммуникативной компетенции, применения интерактивных методов и цифровых технологий в учебном процессе. Анализируются особенности работы с младшими школьниками, а также приводятся рекомендации по повышению эффективности уроков. Материал может быть полезен учителям русского языка, методистам и педагогам начальных классов.
Requirements Analysis Document
Creators: name: Spalding, Dylan
name: Parkinson, Helen
name: Rambla, Jordi
name: Jareborg, Niclas
name: Abdulrahman Azab
name: Lappalainen, Ilkka
name: Almaida-King, Jeff
name: Senf, Alexander
name: Ur-Rehman, Saif
Publisher: name: Zenodo
Year: 2016
Subjects: bioinformatics
human data

description: This document details the purpose, features, and expected interfaces for the complete EXCELERATE WP9 (Use Case D: ELIXIR framework for secure archiving, dissemination and analysis of human access-controlled data). It outlines the tasks the system will perform, the constraints under which it operates, and how it reacts in certain circumstances. This document is intended for stakeholders, designers and developers as well as users of the system, and derives from a joint analysis carried out with these groups.
AnaEE France - une Infrastructure nationale au service de l'Ecotoxicologie
Creators: name: Denaix, Laurence
Publisher: name: Zenodo
Year: 2024
Subjects: subject: ecotoxicology
subject: Ecosystems
subject: Research Infrastructure
subject: Pollution
subject: Biogeochemistry

description: Poster réalisé dans le cadre du 8ème Séminaire du réseau d’écotoxicologie terrestre et aquatique à La Rochelle du 13 au 15 novembre 2023. Ce poster présente les outils scientifiques de l'infrastructure AnaEE France mobilisables pour la recherche en ecotoxicologie terrestre et aquatique.
title: Structural and sedimentological interpretation of the borehole image log in well Tawatawa-1
Creators: name: Griffin, Angela G.
Publisher: name: GNS Science
publisherIdentifier: https://ror.org/03vaqfv64
publisherIdentifierScheme: ROR
Year: 2024

description: The well Tawatawa-1 was drilled in the offshore East Coast Basin in September 2004, to assess petroleum prospectivity in the basin. The well, located in 209.6 m of water, had resistivity borehole image log and wireline log data acquired through most of the well. Sidewall cores were also acquired; however, no conventional core was cut, making calibration with the image log unachievable. The image log has been interpreted and provides an insight into the subsurface structure and stress, and to a lesser extent, the sedimentological nature at the well location in the southern East Coast Basin. A simultaneous acoustic and resistivity imager device was used to acquire a resistivity image over the interval 750–1538 mRT (metres below rotary table) in Tawatawa-1. Low resistivity (i.e. conductive) fractures are the dominant fracture type in the imaged interval. In-situ stress features were also identified over the interval, particularly borehole breakouts, which provide the minimum horizontal stress direction (Shmin). Few of these features were deemed suitable in determining the present-day in-situ stress direction at the well location.  Few sandstone beds were identified in the image log, however, there were not enough to confidently ascertain any sediment dispersal trends. Interbedded sediments combined with the sandstone beds suggest pulses of sediment, possibly as a series of turbidity currents being deposited at or around the vicinity of the well location. The present-day in-situ stress orientation in Tawatawa-1 suggests an Shmin azimuthal orientation of NE-SW. No indicators of SHmax were identified in Tawatawa-1, however, the inferred SHmax direction of NW-SE in Tawatawa-1 is similar to that interpreted in other wells in the southern East Coast Basin. The onshore Ranui-2 and offshore Titihaoa-1 wells also had image logs acquired in them, with NW-SE SHmax azimuthal orientations interpreted from these logs. This “fourth order of stress” (since it occurs at a wellbore scale (1–1000 m scale) SHmax orientation is approximately perpendicular to the regional-scale stress field of the southern Hikurangi Margin, which is considered to be a ‘third order’ stress orientation (<100 km). Faults have been interpreted from seismic lines in the offshore Hikurangi Margin, and it is possible that some of these faults are active and affecting the present-day stress in Tawatawa-1. The results from Tawatawa-1 can be combined with that from the nearby offshore Titihaoa-1 well, located 27 km southwest of Tawatawa-1, and onshore wells Ranui-2, Orui-1A and Te Mai-2, in the southern East Coast Basin, which have all had image logs acquired in them. Together, these data may provide an insight into the subsurface structure and stress in the southern East Coast Basin. (auth)
title: “If You Never Came in and Saw Me, You Would Probably Be Dead”: Exploring Intercultural Communication and Health Communication Issues Surrounding PCOS
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: Polycystic ovarian syndrome is a multifactorial, heterogeneous, complex genetic, endocrine and metabolic disorder which is characterized by chronic anovulation, and biochemical and clinical manifestations of hyperandrogenism (Allahbadia & Merchant, 2010). Symptoms of PCOS include infertility, obesity, hirsutism and alopecia. Moreover, women with PCOS endure discrimination due to the inability to conceive and deliver healthy children, maintain healthy weight, or obtain beauty as defined by dominant societal standards. This dissertation calls attention to the quality of care and support for nondominant individuals and groups in dominant healthcare settings. The dissertation also works to highlight communication issues surrounding PCOS, and address knowledge gaps in causes and cure. Women living with PCOS experience subtle insults and invalidations by dominant group members who may be unaware of the condition, resulting in unintended emotional harm. This phenomenological study explored the communicative experiences of sixteen women diagnosed with PCOS, and five health care practitioners. The semi-structured interviews foreground general and nonmonolithic interactions associated with the invisible disease. Results yield four major themes: 1) the road to diagnosis; 2) the lived experiences of patients; 3) microinvalidations; and 4) physicians’ communication. Additionally, the study revealed communicative tensions and strategies to achieve desired health outcomes. These respective voices contribute to knowledge about patients’ interactions with doctors, family and friends. Prior studies have explored invisible disease, but few studies include international populations. This research draws from the perspectives of African and African American women, European American women, and Hispanic women. Their educational backgrounds ranged from High School Diplomas to Ph.D. holders. Salaries ranged from 20k – 100k annually. Consequently, the value of this research includes contextualized experiences with PCOS across ethnicity, social economic status, education and age. Readers will also gain a better understanding of the precarious connection between communication and invisible disease.
title: Planning and early warning systems for cascading natural hazard risk
Creators: name: Bretherton, Edith V.
name: Charlton, Danielle H.
Publisher: name: GNS Science
publisherIdentifier: https://ror.org/03vaqfv64
publisherIdentifierScheme: ROR
Year: 2024

description: Aotearoa New Zealand is at risk from cascading hazards triggered by a catastrophic natural hazard event. Many pieces of legislation and guidance form the governance framework, with a variety of operational systems running concurrently. Currently, most governance and operational responses do not consider cascading hazard risk, apart from the AF8 SAFER (South Island Te Waipounamu Alpine Fault Earthquake Response) framework. Recommencing the H9 programme , for regions likely impacted by a Hikurangi Subduction Zone margin, is recommended. Using land-use planning for maximum credible scenarios would substantially impact day-to-day life and could outweigh the potential loss of life and damage to the environment, communities and infrastructure, depending on the probability of that event occurring. Further research into acceptable levels of risk when balanced against potential loss and potential mitigation costs and impact is recommended to understand appropriate risk-management responses in an Aotearoa New Zealand context. (auths)
Autoimmune diseases share a common genetic architecture involving the JAK-STAT pathway
Creators: name: Saadat, Iraj
name: Saadat, Mostafa
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2024
Subjects: autoimmune diseases
GWAS
enrichment analysis
JAK/STAT pathway

description: EXCLI Journal; 23:Doc1027; ISSN 1611-2156
The contribution of quality management practices to student performance: Mediated by school culture
Creators: name: Parveen, Khalida
name: Quang Bao Phuc, Tran
name: Alghamdi, Abdulelah A.
name: Kumar, Tribhuwan
name: Aslam, Sarfraz
name: Shafiq, Muhammad
name: Saleem, Atif
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 39
subject: Education

description: School management is responsible and accountable for implementing educational policies into practice effectively and efficiently to provide quality education. Simultaneously, school management can grasp the core features of the whole school process and identify the relationship among three variables: quality management practices, school culture, and student performance. The current study aims to explore the school principals’ perception about quality management practices and its relationship with school culture and student performance in the public secondary schools of Punjab province, Pakistan. In order to achieve the objectives of the study, the study adopted an exploratory sequential mix-methods research design. The researcher conducted a systematic literature review of sixty-three previous studies and interviews with eleven school principals for the qualitative data. Based on results obtained from the qualitative phase, a questionnaire was prepared and dispatched to 150 school principals to get quantitative data. Successively 120 valid responses were received. SEM analysis was performed to get quantitative results. The study’s preliminary conclusion demonstrated a positive connection between quality management and student performance in public secondary schools, and quality management was also a significant predictor of school culture. Further, school culture served as a complete mediator between quality management and student performance
title: NOVEL MOLECULAR MEMORY ON SI AND TWO-DIMENSIONAL MATERIALS
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2019

description: The dimensional scaling down of microelectronics to further increase the storage ability and density is confronting the fundamental and physical limit. The performance of high density, low power consumption non-volatile memory as the important part in portable electronic devices like cellphone, tablet and laptop will have a drastic impact on these devices. Molecular electronic technology has attracted much attention due to its nanoscale features, flexibly tunable properties and tremendous application prospects, etc. Replacing the currently used traditional flash memory with high-performance Flash-based molecular non-volatile memory for further scaling down, will be an effective method for increasing storage density and stability. In this study, we introduce the development of molecular electronics in the application of non-volatile memory. Recently, solid-state non-volatile memory devices based on redox-active molecules have been reported, exhibiting fast speed, low operation voltage, excellent endurance and multi-bit storage, outperforming the conventional floating-gate flash memory. I have fabricated and characterized a kind of Flash-like Ru molecular memory devices. This Ru molecular exhibit excellent memory window under high-frequency CV measurement. The programming and erasing response speed are also suitable for Flash memory applications. The stability of our molecular memory devices is demonstrated by endurance characterization for more than 105 cycles. The charge storage in these molecular memory devices is basically derived from the intrinsic redox processes lead by a sweeping gate voltage bias. Compare with the traditional flash memory, the intrinsic redox and the stable molecular properties lead to a very reliable and high-density charge storage ability. Two-dimensional materials, especially layered transition metal dichalcogenides (TMDCs), such as molybdenum disulfide (MoS2) and tungsten diselenide (WSe2) have recently become superstar materials as nanomaterials for future flexible, portable and high-performance electronic devices due to their excellent physical, electrical and mechanical properties. We have developed approaches of redox-active molecule attachment on 2-dimensional materials. Redox-active molecular memory based on 2-dimensional materials have been fabricated and measured. Our finding about redox-active molecule provides many opportunities for novel non-volatile memory applications.
title: Affirmative and Ironic Resonances from the Personal Sheet Music Collection of Julia Ward Howe
Creators: name: Gerber, Steven K.
Publisher: name: George Mason University
Year: 2015
Subjects: subject: Howe, Julia Ward
subject: Owner-bound volumes
subject: Musical rarities
subject: 19th-century music

description: Paper presented at joint conference of Atlantic and New York State/Ontario Chapters of Music Library Association, held at Duquesne University, Pittsburgh PA on October 4-5, 2013.
description: Julia Ward Howe (1819-1910), the prominent 19th-century poet and reformer who famously penned the lyrics to “Battle Hymn of the Republic,” collected and bound for personal use five volumes of music; three volumes bear labels stamped “Miss Julia Ward” and two are labeled “Julia Howe,” postdating her 1843 marriage. The collection includes two complete operas in vocal score: Rossini’s Il Mose in Egitto and Beethoven’s Fidelio. The other three volumes contain 76 individual songs, primarily Lieder in German editions, but also 28 American imprints that range from Anglo-American sentimental songs to translations of European art songs and arias; most date from the 1830s and early 1840s. Howe’s adolescent education included musical training, and her singing and piano-playing around domestic hearths before and after her marriage was admired. She quickly rose to prominence both for her literary work and for her activism in favor of abolitionism and other causes, while diligently performing duties as mother to six children and wife to a physician and writer (who did not appreciate her talents and actively opposed her career and her emerging feminism). Her choice to acquire Mose in Egitto, a drama about deliverance from slavery, seems congruent with her abolitionist positions, while her interest in Fidelio, a drama about a courageous and self-empowered wife who rescues a grateful and loving husband (a score acquired after her marriage), resonates ironically with her actual domestic situation. With exceptions, the contents are atypical of such American owner-bound music albums, and the individual songs mirror the cultivated tastes of an educated connoisseur; minstrelsy is conspicuously absent.
The archaeological collection from the southern interior of British Columbia
Creators: name: Smith, Harlan Ingersoll, 1872-1940
Publisher: name: Ottawa : Government Printing Bureau
Year: 2015

description: Canada. Department of Mines. Geological Survey, Museum of the Geological Survey, Canada. -- Cover.

No. 1290 -- Cover.

Publications on the archaeology of the southern interior of British Columbia : page 40.

At the head of title on cover: Archaeology.
title: Social Isolation Effect on Nicotine Consumption in Adolescent Mice
Creators: name: Ko, Ji-Hye
Publisher: name: George Mason University
Year: 2018
Subjects: subject: Adolescence
subject: Nicotine addiction
subject: Social isolation
subject: CD81
subject: Estrous cycle
subject: Nicotine withdrawal

description: Adolescence is a period of increased vulnerability to nicotine addiction and a time when sensation seeking reaches its maximum value. Since the developmental trajectories of sensation seeking and impulse control are different, there are higher chances of risk-taking behaviors during that period. Also, adolescence is a period of being hypersensitive to rewards, especially the salience of social cues. Therefore, social context becomes a significant influence on drug use and abuse. This thesis describes the effects of social isolation on nicotine consumption in mid-adolescent mice who consumed nicotine voluntarily starting at postnatal day 40. We previously reported that nicotine consumption in socially isolated mice who started to consume nicotine at postnatal day 30 was significantly higher than in pair-housed mice, especially in males. Here, we extend our experiments to mid-adolescent mice, as well as Cd81 -/- mice (whose nicotine consumption increased significantly in both adults and early-adolescents). We also tested for the effects of estrous cycle on nicotine consumption in early adolescent females (starting on postnatal day 30). After the nicotine self selection, behavioral and emotional sings of withdrawal were measured. Here, we report that mid-adolescent nicotine consumption was increased by Cd81 loss-of-function in females, but not in males. After 24 h of nicotine abstinence, behavioral withdrawal signs were not significant and/or were decreased. In tests of emotional behavior, mice did exhibit emotional changes after 24 hr of nicotine abstinence, and these emotional changes appeared to be influenced by previous pair- vs. single-housing conditions. In early-adolescence, females began their estrous cycles around postnatal day 40, and their nicotine consumption was the lowest at the estrus stage (when estrogen levels are the lowest), and the highest during late metestrus/diestrus stage (when estrogen level starts to increase).
Registry Release With Comprehensive Coverage Of Elixir Node Resources, Including Resource Data Format Curation And Analysis
Creators: name: All EXCELERATE-funded partners, and many other non- ELIXIR organisations (see https://bio.tools/governance) have contributed to this work
Publisher: name: Zenodo
Year: 2016
Subjects: bioinformatics
software resources

description: The objective of EXCELERATE Deliverable 1.1 is the development of a discovery portal (bio.tools) built upon a federated curation of a wide range of key software resources for bioinformatics worldwide. The core aim is to provide a practical portal that will help scientists not only find, understand, compare, and select resources (“discovery”), but also use and connect them in workflows (“interoperability”). Underpinning the portal is a registry of software information; the cornerstone of the WP.
title: Guayaquil Antiguo and Cacao Capitalism during the Long 19th Century: On the Peripheral Origins of Planetary Urbanization
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2019

description: This dissertation examines the link between agricultural commodity production, the production of urban space, the uneven environmental impacts of development, and the shifting configuration of the world economy through the lens of coastal Ecuador and Guayaquil’s experiences with cacao capitalism from 1760 to 1930. Framed through novel debates touching upon peripheral urbanization, agricultural capitalism, and political economy, my work explores the valorization of “rural” land as articulated by the city-centered bourgeoisie in Guayaquil. As cacao prices rose, banks and capitalists quickly extended capital investment into the tropical countryside, amplifying an uneven political economic circuit sutured by overlapping and conflicting cultural practices filtering through Guayaquil. Class and racial tensions, mediated by the competing categories of the “tropical” and the “modern,” expressed how these unequal practices materialized in this extended urban geography. Concurrently, I investigate the solidification of the discursive construct of Guayaquil Antiguo, the coastal bourgeoisie’s urban imaginary regulating and reacting to social changes in Guayaquil as cacao capitalism collapsed during the 1920s. Using qualitative and quantitative archival methods, I recreate Guayaquil’s historical urbanization by analyzing travel narratives, city guides, municipal reports, newspapers, banking records, and many other sources, tracking Guayaquil’s planetary urbanization in order to grasp the long-history of peripheral urban political ecology and economy. My main theoretical contribution to urban and global sociology centers on how I trace the historical develop of Guayaquil as an integrated network of value production and circulation expanding urbanization through the countryside, as a case study outlining the structural constraints of peripheral capitalism.
Genotyping of Crb1 And Rp1 Genes In Families With Visual Impairment (Retinitis Pigmentosa)
Creators: name: Rasheed, Arsalan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biological Engineering
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences
subject: 60406 Genetic Immunology
subject: 60408 Genomics
subject: Immunology
subject: FOS: Clinical medicine
subject: Medicine
subject: Molecular Biology
subject: 60410 Neurogenetics
subject: Pharmacology
subject: Physiology
subject: 60411 Population, Ecological and Evolutionary Genetics
subject: 60412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

description: Almost 285 million individuals suffer from vision impairment worldwide in which 90% live in underdeveloped countries. A total of 150 mutations and 60 genes have been associated to Retinitis Pigmentosa. In the current study, two families with Retinitis Pigmentosa were identified in Kohat, Khyber Pakhtunkhwa, Pakistan. The pedigree analysis indicated an autosomal recessive pattern of Retinitis Pigmentosa inheritance. The non-syndromic nature of Retinitis Pigmentosa was confirmed by clinical evaluation of affected members by an eye specialist. Homozygosity mapping was used to analyze the linkage of two families, RP1 and RP2. The microsatellite markers D1S2816, D1S2840, D1S1183, D1S1660, D1S158, D1S422, D1S412, D1S413, D8S532, D8S260, and D8S509 were chosen for linkage analysis in the RP1 and RP2 families. Affected members of the RP1 family (III.1, III.2, III.3, and III.4) demonstrated homozygosity at the D8S260 marker. Individuals from the RP2 family that were impaired (III.3 and III.4) showed homozygosity at marker D1S1660. The CRB1 locus was used to confirm family linkage in RP1, while the RP1 locus was used to confirm family linkage in RP2. Haplotyping confirmed the allelic pattern in RP1 and RP2 families. Protein-protein interactions were investigated using the Stitch 5 database, and the closest functional partner was discovered. The one closest to CRB1 has a maximum interaction score of 0. 978.The interaction of a mutant protein with other proteins and how it affects the pathway can be predicted by applying this research study. This research could aid in prenatal diagnostics and gene therapy for linked diseases in the future.
Supplementary document for Design of wavelength division multiplexing devices based on tunable edge states of valley photonic crystals - 6363688.pdf
Creators: name: Wang, xiaorong
name: Han, Yuhui
name: Fei, Hongming
name: Lin, Han
name: Zhang, Mingda
name: liu, xin
name: cao, binzhao
name: Yang, Yibiao
name: Chen, Zhihui
name: Xiao, Liantuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Design of wavelength division multiplexing devices based on tunable edge states of valley photonic crystals
title: Espoused and Enacted Values in Fraternal Organizations
Creators: name: Schwartz, Nancy
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Fraternity
subject: Sorority
subject: Values
subject: Espoused
subject: Enacted

description: This thesis investigated the differences between the enacted and espoused values of fraternities and sororities and examined how these differences are affected through a gendered lens and in the areas of ethical decision-making, risky behavior and cognitive development. The research explored how students’ perceived understanding of gender and ethical decision-making affected their ability to enact the espoused values of their organization. Using sociological and heuristic case study approaches, research revealed students’ experiences with espoused and enacted values, their attitudes around gender development and risky behavior in their community and how they felt it has affected their ability to make meaning and as well as ethical decisions. These attitudes were reflected in the themes of membership social standing and values. Findings from this study suggest a need for an experiential learning based new member process. This change in new member process would, based off of participant accounts, allow for a more in depth relationship to be formed between the organization’s values and the values of the individual member. Findings also suggested a need for an increase in members understanding of gender role conflict and organizational culture though universityfacilitated programs.
Correlated accidents
Creators: name: Franzoni, Luigi Alberto
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: SECS-P/03 Scienza delle finanze

description: This paper investigates cases in which harms are statistically correlated. When parties are risk averse, correlation plays an important role in the choice between liability rules. Specifically, positively correlated harms favor a liability rule that spreads the risk over a multitude of parties, as in the negligence rule. Negatively correlated harms favor a liability rule that pools risks together, as in strict liability. The same applies when parties can purchase costly insurance (first party or third party). This policy recommendation is in line with current products liability law, which places design defects and warning failures under a de facto negligence regime.