cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bayesian approaches for mapping forest soil organic carbon
Creators: name: Clough, Brian J.
Publisher: name: No Publisher Supplied
Year: 2014

description: Forest soil organic carbon (SOC) is the largest terrestrial pool of carbon, and its management plays a significant role in global efforts to mitigate atmospheric carbon concentrations. Despite its importance, much of the world is still lacking good baseline data of forest soil carbon stocks. In the past, broad scale stocks of forest SOC have been derived from soil surveys based on a small number of sampling units, and the resulting estimates are highly uncertain. More recently, predictive statistical models have received attention as an approach for mapping soil carbon at scales relevant to climate change policy and research. However, in order for these models to be useful they must provide full and accurate accounting of uncertainty, in addition to accurate predictions.    This dissertation aims to improve prediction of forest SOC by incorporating two potentially important sources of uncertainty into the modeling process: (1) spatial dependence in soil inventory data; and (2) error associated with assuming a single model to be “true”. In order to address these issues, we turn to well established techniques in the Bayesian statistics literature. Our primary focus is on exploring the application of spatial Bayesian hierarchical regression models for improving estimates of forest carbon. This line of research involves both characterizing the spatial dependence in forest SOC inventories at regional, national, and continental scales (the focus of chapters 1 and 3), and applying spatial hierarchical models for mapping SOC and validating this method against non-spatial approaches (chapter 4). Additionally, in chapter 2 we compare methods for model selection and weighting, as well as the effect of model averaging to account for model uncertainty, through rigorous predictive checks. This work is conducted with both forest SOC data as well as other ecological datasets.    Taken together, these studies highlight the need for a consistent statistical framework in order to generate reproducible estimates of forest SOC stocks across the globe. Our results argue for hierarchical models, and especially spatial hierarchical models, as a reasonable way forward for predictive mapping of SOC. However, they also highlight significant methodological development that will be necessary in order to obtain predictively accurate models.
Human iPSCs for Elucidating Cardiovascular Risks of E-Cigarettes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking remains the leading cause of preventable death in the United States, responsible for approximately half a million deaths per year. Evidence has shown that smoking can harm nearly all organs of the body, with the greatest morbidity and mortality in the lung and heart. In recent years, electronic cigarettes (e-cigarettes) have risen in popularity to become the top smoking cessation aid. E-cigarettes are devices designed to imitate regular cigarettes that deliver a nicotine-containing aerosol to users by heating a solution typically consisting of propylene glycol or glycerol (glycerin), nicotine, and flavoring agents via inhalation without combusting tobacco. Although e-cigarettes are marketed as a safer alternative to conventional cigarettes, their use is not without controversy, and the scientific community has been concerned because the potential harmful health effects of e-cigarette smoking are largely unknown. Unanswered questions remain about their overall toxicological effects and safety, efficacy of harm reduction, and mechanism(s) of action. In addition, e-cigarette smoking’s effects on the cardiovascular function remain poorly understood. Smokers develop various forms of smoking-related cardiovascular disease with a diverse severity and speed of progress suggesting that individual genetic factors play a key role in the development of cardiovascular disease. However, it is difficult to prove currently due to the lack of an appropriate human model.

 With the advent of patient-specific induced pluripotent stem cells (iPSCs) that can be differentiated into disease-relevant cell types, such as heart cells and endothelial cells, investigation of e-cigarette smoking-related cardiovascular dysfunction with unique human genetic background becomes feasible. The key objective of this TRDRP High Impact Research Project Award proposal is to elucidate the genetic impact on the initiation and development of e-cigarette smoking-related cardiac and endothelial dysfunction at the cellular level. Data collected using this methodology can inform the public about the potential deleterious consequences of e-cigarette smoking and second-hand exposure to e-cigarettes. The proposed studies would give the FDA important knowledge-based tools to protect the public health in today’s rapidly evolving tobacco marketplace, including the review of new e-cigarette products and their health-related claims.
Cervilissa versicolor Monne, M.A. & Monne, M.L. 2000
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Cervilissa
Cervilissa versicolor

description: 27. Cervilissa versicolor Monné, M.A. & Monné, M.L., 2000: 2, figs. 1, 2 Holotype, female
Type locality. Brazil, Mato Grosso: Cáceres, 15.XI.1984, Buzzi, Mielke, Elias & Casagrande
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 345, DOI: 10.5281/zenodo.250291
Shear Stress : a Master Regulator of the Endothelial Chromatin Landscape
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking harms the vascular system because toxic chemicals in cigarette smoke damage endothelial cells, a single layer of cells that forms the inner lining of blood vessels. These cells play very important roles in maintaining healthy vascular function, for instance by preventing blood clotting and regulating blood pressure. When damaged, these cells lose their protective functions, which leads to disease. Endothelial cells are in direct contact with the bloodstream and sense the friction generated by blood flow. Normal blood flow observed in straight parts of the vasculature preserves healthy function by inducing protective genes, while disturbed flow seen at vessel branches induces genes that favor disease. We do not fully understand how exposure to different types of blood flow can protect some cells from the damaging effects of cigarette smoke while making others more vulnerable.

 We think that the answer lies in the way our DNA is organized. Every cell in our body has the genetic codes for all our genes, but because different cell types have different functions, not all genes have to be turned on in a specific cell. Genes that are not required are turned off and tightly packed in our DNA. For genes to be active, the DNA has to be unwound to allow certain proteins to bind the DNA and activate the gene. We will study how blood flow affects opening and closing of DNA and how this results in protective or disease-associated gene activation. By understanding the mechanisms and factors that open DNA of protective genes and close DNA of genes that make cells more vulnerable to the damaging effects of cigarette smoke, we can develop better therapies to prevent and treat vascular disease, a major cause of death and disability related to smoking.
Genetic dissection of oncogenic Kras signaling in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS is one of the most frequently altered genes in human cancer, and mutations in KRAS occur in 30% of lung adenocarcinoma. KRAS is a type of protein called oncogene, which means that when it gets mutated it drives cancer growth. Despite decades of attempts, therapies to directly “turn-off” oncogenic KRAS have not been discovered. There are many different flavors of oncogenic KRAS (called KRAS variants) and oncogenic KRAS controls many different things inside the cancer cell. Personalized medicine directed towards different oncogenic KRAS variants and the things that it controls has great potential for the treatment of KRAS-driven lung cancer.

 My project will answer why and how different KRAS variants causes lung cancer and may uncover novel druggable targets for precision treatment. In my project, I will first study the differences among oncogenic KRAS variants in a lung cancer model. I will also determine which other proteins that touch oncogenic KRAS are actually important for cancer growth. To study different oncogenic KRAS variants in lung cancer, I will replace the normal KRAS gene with different oncogenic Kras variants in the mouse lung. To uncover novel proteins that touch oncogenic Kras, my co-mentor Dr. Peter Jackson's laboratory used a fancy method where they can extract oncogenic Kras from cells and then identify all of the other proteins that are stuck to it. Finally, I will use a powerful system established in our laboratory (which uses CRISPR/Cas9-mediated genome editing) to delete several candidate proteins that bind to Kras and to determine their importance during cancer growth in vivo.

 My project is entirely unique from what other people in the field are doing and it has the potential to identify novel therapeutic targets that could aid in the treatment of patients with lung cancer. I hope that my work will make an impact on patients with this devastating disease. I am dedicated to working toward a world in which genetic analysis of lung tumors will enable patients to be treated with the right drugs.
Ceratosoma tenue Bergh 1874
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ceratosoma
Ceratosoma tenue

description: Ceratosoma tenue Bergh, 1874
(Figure 3 I –J)
Material examined. Eight specimens. MB28-004535, ZSC, 14 May 2012, 22 m, 34mm; MB28-004606, 15 Aug. 2012, ZWH, 18m, 62mm; MHN-YT1066, ZWH, 11 Jan. 2014, 17m, 49mm; MHN-YT801, ZM, 13 Jun. 2013, 8m, 22mm; MB28-004738, ZRP, 19 Sep. 2013, 1m, 22mm; MB28-004837, POB, 0 9 May 2014, 18 m, 27mm; ZMBN119699, ZRP, 17 Jul. 2015, 0.5m, 18mm; MB28-004610, ZY, 19 Aug. 2012, 34m, 30mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurences: Ponta do Ouro and Zavora.
Geographic distribution. Indo-west, central Pacific. Hawaii (Gosliner et al. 2008), Japan (Baba 1949), Korea, Papua New Guinea, New Caledonia, Australia, Malaysia (Gosliner et al. 2008), Indonesia (Debelius 1996), Tanzania, South Africa and Mozambique (Gosliner et al. 2008).
Remarks. The bathymetric distribution of this species ranged from 1 to 50m. We found two morphotypes: one found in shallow water was smaller and similar to specimens from Tanzania (Rudman 1988) with a bright yellow background and lateral lobes of different sizes (Fig. 3 I); the second morphotype found in deeper water was much larger and predominantly reddish. In this morphotype the anterior lobes are slightly smaller than the posterior lobes (Fig. 3 J). Additional molecular and morphological studies are needed to test the co-specificity of both morphotypes.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 16, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Chariergus paranaensis Napp & Reynaud 1998
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Chariergus
Chariergus paranaensis

description: 28. Chariergus paranaensis Napp & Reynaud, 1998: 156, fig. 2 Holotype, male
Type locality. Brazil, Paraná: Quatro Barras (Pico do Paraná, 1700 m), 23.I.1970, Laroca & Becker Current name. Allopeba paranaensis (Napp & Reynaud, 1998)
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 345, DOI: 10.5281/zenodo.250291
SRF Phosphorylation and the Progression to Heart Failure
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking is toxic to the heart and blood vessels due to the numerous injurious chemicals that are inhaled, including nicotine and carbon monoxide. Tobacco use thereby increases the risk that smokers and others exposed secondhand to tobacco smoke will have atherosclerosis and heart disease, including heart attacks and sudden death. Those who survive a heart attack or have other cardiovascular diseases like high blood pressure are likely to develop heart failure. Heart failure is characterized by shortness of breath, decreased exercise tolerance and fatigue, and fluid retention, such as swelling of the ankles or “wet lungs” (pulmonary edema). Heart failure is currently associated with a 50% chance of death within 5 years of the onset of symptoms despite improvements in the care of heart failure patients and the use of such drugs as ACE inhibitors and beta-blockers. We have been studying how the heart muscle reacts to stress in disease in an attempt to identify new cellular proteins that may be targeted by new heart failure drugs. We have identified a novel property of a protein called SRF that regulates how genes are expressed in the cardiac myocyte, the cell type responsible for heart pumping action. We have found that SRF is altered in models of heart disease in a way such that this modification may contribution to the enlargement of the heart in heart failure. In this grant, we will be studying how SRF is regulated in heart failure, and we will test new approaches to restore normal SRF function and prevent heart failure. In particular, we will testing two new biologic drugs that may be useful in preventing heart failure. We will test these biologic drugs in small rodent models of heart attacks (myocardial infarction) and high blood pressure. In combination with basic molecular and cellular biology research that will reveal how SRF function is altered in the stressed heart, we expect to define SRF as a novel drug target for heart failure therapies.
Ceratosoma trilobatum J.E. Gray 1827
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ceratosoma
Ceratosoma trilobatum

description: Ceratosoma trilobatum (J.E. Gray, 1827)
(Figure 3 K)
Material examined. One specimen. ZMBN117034, ZKW, 11 Dec. 2012, 50m, 92mm.
Habitats. Wreck in the subtropical region.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. Japan, Taiwan, New Caledonia, Indonesia (Gosliner et al. 2008), Philippines, Australia, Malaysia, Vietnam (Coleman 2008), Red Sea, Madagascar (Gosliner et al. 2008) and Mozambique (King & Fraser 2014).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 16, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Ethemon lepidum subsp. rufofemorale Napp 1979
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Ethemon
Ethemon lepidum
Ethemon lepidum rufofemorale napp, 1979: 906

description: 29. Ethemon lepidum rufofemorale Napp, 1979: 906, figs. 15, 32, 34 Holotype, male
Type locality. Brazil, Paraná: Curitiba, 09. II.1972, Dilma Solange Napp
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 345, DOI: 10.5281/zenodo.250291
Predilection of CHRNA5 SNP to smoking-related cardiotoxicity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking, the leading cause of preventable deaths, is responsible for nearly half a million deaths per year in the United States. Evidence has shown that smoking can cause diseases of nearly all organs of the body with the greatest morbidity and mortality in the lung and heart. It is clear that smoking increases the risk of cardiovascular disease, whereas how smoking worsens the heart function remains poorly understood. In addition, different smokers are projected to develop smoking-related cardiovascular disease with a diverse severity and speed of progress. These facts suggest that individual unique genetic factor and smoking play a combinatorial role in the development of cardiovascular disease. However, this theory is difficult to prove previously due to the lack of human heart samples. With the advent of patient specific induced pluripotent stem cells which can be differentiated into heart muscle cells, investigation of smoking-related cardiac dysfunction with human genetic background becomes feasible. The key objective of this TRDRP postdoc fellowship proposal is to elucidate the genetic impact on the initiation and development of smoking-related cardiac dysfunction at the cellular level. The outcomes of this research will provide a strong evidence that genetic biomarkers can be used for early detection of smoking-related cardiovascular disease. Furthermore, this research project will offer a proof-of-principle for using induced pluripotent stem cell platform to screen potential compounds for treatment of smoking-related cardiovascular disease.
MOESM3 of High-throughput SuperSAGE for gene expression analysis of Nicotiana tabacum–Rhizoctonia solani interaction
Creators: name: Portieles, Roxana
name: Ochagavia, María
name: Canales, Eduardo
name: Yussuan Silva
name: Osmani Chacón
name: Hernández, Ingrid
name: Yunior López
name: Rodríguez, Mayra
name: Terauchi, Ryohei
name: Borroto, Carlos
name: Santos, Ramón
name: Bolton, Melvin
name: Ayra-Pardo, Camilo
name: Borrás-Hidalgo, Orlando
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology
subject: 60506 Virology

description: Additional file 3: Table S2. List of the up and down regulated annotated tags with highest fold change of tobacco plants inoculated with Rhizoctonia solani.
Ceratosoma A. Adams & Reeve 1850
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ceratosoma

description: Ceratosoma sp.
(Figure 3 L)
Material examined. Five specimens. MB28-005071, ZAR, 0 9 Aug. 2011, 30m, 12mm; MHN-YT415, ZD, 0 3 Jun. 2012, 32m, 3mm; MB28-00 5072, POR, 0 7 May 2014, 15m, 10mm; MB28-005073, POC, 0 8 May 2014, 18m, 21mm; MB28-005074, ZY, 24 Feb. 2015, 31m, 7mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indo-west, central Pacific. Hawaii, Japan, Papua New Guinea, Guam, Philippines, Indonesia, Seychelles, Madagascar (Gosliner et al. 2008), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 17, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Clinical Significance of Minority HIV-1 Drug Resistance Variants
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The high mutation rate of HIV-1 and the complex population genetics of HIV-1 within infected patients complicates the use of antiretroviral (ARV) drug resistance testing in both previously untreated and treated patients because standard genotypic resistance tests are unable to detect minority drug-resistant variants present at levels below 20% to 30% of the virus population in a clinical sample. This inability to detect minority drug-resistant variants may threaten the success of first-line ARV therapy at a time when transmitted HIV-1 drug resistance has become common and may have a negative influence on the success of salvage therapy regimens. The overriding goal of this proposal is to use a new but increasingly used sequencing technology (ultra-deep pyrosequencing) that can reliably detect variants present in as few as 1% of a virus population – to characterize the extent of minority ARV drug-resistant variants in several clinical settings and to begin to assess the risk these variants pose to first-line and salvage ARV therapy. The results of our proposed studies will lead directly to improvements in genotypic resistance test interpretation and ARV treatment strategies. They will also pave the way for larger studies designed to quantify the clinical relevance of minority HIV-1 drug resistance mutations in diverse clinical settings. Ultra-deep pyrosequencing is a new but increasingly used sequencing technology capable of sequencing individual molecules in a complex mixture of medically relevant genetic populations such as that found in a viral quasispecies. This proposal outlines six planned pilot studies: three are relevant to successful first-line ARV treatment and three are relevant to successful salvage ARV treatment. Each of the pilot studies builds on the long-term collaboration between Stanford University and the Kaiser-Permanente Medical Care Program (Northern California) and on the experience of the Stanford researchers at ultra-deep pyrosequencing. The results of the pilot studies outlined in this proposal will be pivotal in planning future larger studies of the clinical relevance of ultra-deep pyrosequencing and of other technologies for detecting minority drug-resistant variants. The foremost goal of this proposal is to determine whether the insights gained from our proposed studies can be used to improve ARV treatment strategies. Subsequent studies will be necessary to determine the potential role of ultra-deep pyrosequencing in the routine management of HIV-1 –infected patients.
Novel regulation of the Rb pathway in breast epithelium
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The development of breast cancer from normal cells in the mammary epithelium requires multiple mutations in cellular genes. In particular, members of a class of genes called tumor suppressors are often lost in breast cancer; these genes usually act as cellular brakes, preventing breast cells from abnormally multiplying. Our research focuses on the pRB family of tumor suppressors, comprising pRB (retinoblastoma protein) itself, and the associated proteins p107 and p130. Normally pRB prevents the cell from replicating damaged DNA by blocking its progression through the cell cycle. Thus, when pRB becomes ineffective, mutated cells can continue to divide and this can lead to cancer initiation and progression. In fact, the function of pRB family proteins is altered in more than 80% of breast cancers, and our goal is to understand how this family of proteins normally prevents cells in the mammary gland from becoming tumor cells.

 In the breast, the function of the RB-related proteins, p107 and p130, need to be inactivated in addition to that of pRB before cancer can occur. Thus, the conventional thinking is that p107 and p130 display compensatory, although not well understood functions that prevent pRB-deficient mammary cells from becoming tumor cells. This project focuses on the regulation and the function of p107 in the mammary gland in mice, with the specific goal of understanding how p107 can block cancer in pRB-deficient breast cells. We propose to study p107 in the mammary epithelium for: (1) expression pattern in various cells; (2) its functional role to prevent proliferation and control apoptosis, and (3) the molecular mechanisms controlling its transcription (i.e., regulation of gene expression). We will use single and double knockout mice for RB and p107 to investigate the functional role of p107 in the presence and in the absence of pRB. These studies will allow us to investigate any unique or overlapping functions that p107 and pRB may have in controlling proliferation and apoptosis in the mammary gland. In addition, we have created mouse embryonic stem (ES) cells with point mutations in the E2F transcriptional control binding sites in the p107 promoter in order to dissect gene regulation.

 Throughout a woman’s life, the breast undergoes a series of hormonally driven developmental changes that involve signaling pathways to prevent abnormal expansion of mammary cells. The proposed experiments will uncover important insights into key nodes in these pathways, such as pRB and p107. A greater understanding of the normal functions of these proteins will allow the further investigation of targeted therapeutic strategies to replace these functions in breast cancer. These molecular therapies may have the potential improve the quality of life of a patient during and after treatment.
title: Bittergurke, Balsambirne :
title: Richtlinien für die Durchführung der Prüfung auf Unterscheidbarkeit, Homogenität und Beständigkeit.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
Bitter gourd
New Varieties of Plants

description: Zweck dieser Richtlinien („Prüfungsrichtlinien“) ist es, die in der Allgemeinen Einführung (Dokument TG/1/3) und deren verbundenen TGP-Dokumenten enthaltenen Grundsätze in detaillierte praktische Anleitung für die harmonisierte Prüfung der Unterscheidbarkeit, der Homogenität und der Beständigkeit (DUS) umzusetzen und insbesondere geeignete Merkmale für die DUS-Prüfung und die Erstellung harmonisierter Sortenbeschreibungen auszuweisen.
Chromodoris aspersa
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris aspersa

description: Chromodoris aspersa (Gould, 1852)
(Figure 4 A)
Material examined. Four specimens. MB28-004432, ZA51, 15 Nov. 2011, 4m, 24mm; MB28-004722, ZDRS, 12 Aug. 2013, 32m, 10mm; MHN-YT1276, NHR, 29 May 2014, 10m, 18mm; MB28-0 0 4952, ZA51, 30 Dec. 2014, 12m, 14mm.
Habitats. Subtropical rocky reefs and tropical coral reefs.
Occurrences. Zavora and Nuarro.
Geographic distribution. Indo-west, central Pacific. Hawaii, Japan, Marshall Islands, Papua New Guinea (Gosliner et al. 2008), Australia (Debelius 1996), Philippines, Réunion Island, Seychelles (Gosliner et al. 2008) and Mozambique.
Remarks. This species typically has an orange or yellow edge around the mantle (Kay & Young 1969; Rudman 1983). Rudman (1993) reviewed the anatomy of specimens of C. aspersa with and without the yellow/ orange border and concluded that they all belong to the same species. Nevertheless, this hypothesis has never been tested using molecular techniques, which may clarify the identity of this taxon.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 17, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
title:  A Monthly Model of the Canadian Financial System
Creators: name: Clinton, Kevin
name: Masson, Paul
Publisher: name: Bank of Canada
publisherIdentifier: https://ror.org/05cc98565
publisherIdentifierScheme: ROR
Year: 1975

description: In this study we describe preliminary estimates of a model of the Canadian financial system. At the present time, the model explains the behaviour of the authorities, the chartered banks, the public, and the trust and mortgage lean companies. The variables explained include monetary aggregates, several interest rates, and the major assets of the chartered tanks and of the trust and mortgage loan companies. The model differs from existing Canadian models in that we use monthly data rather than quarterly or annual data. We think the shorter observation period permits the econometric estimates to capture the dynamic adjustment processes more accurately. In particular, the mean lags implied by our equations tend to be considerably shorter than those in existing models. we have also written a description of this model entitled: "Un Modèle Mensuel du secteur Financier au Canada", which is to be published in l'Actualité Economique in 1976.
description: Ce travail se propose de présenter une première estimation d'un modèle du système financier canadien. Au stade actuel, le modèle permet d'expliquer le comportement des autorités, des banques à charte, du public et des sociétés de fiducie ou de prêt hypothécaire. Parmi les variables expliquées, on trouve des agrégats monétaires, plusieurs taux d'intérêt, ainsi que les principaux avoirs des banques à charte et des sociétés de fiducie ou de prêt hypothécaire. Ce modèle diffère des autres modèles de l'économie canadienne en ce sens qu'il utilise, contrairement à ces derniers, des données mensuelles au lieu de données trimestrielles ou annuelles. Nous pensons que le raccourcissement des périodes d'analyse permet d'appréhender les processus dynamiques d'ajustement avec plus de précision. Soulignons en particulier que le retard moyen sur lequel reposent nos équations tend à être beaucoup plus court que celui qu'on retrouve dans les autres modèles. Nous avons également décrit ce modèle dans un article intitulé "Un modèle mensuel du secteur financier au Canada", qui doit être publié dans l'Actualité économique en 1976.
Chromodoris africana Eliot 1904
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris africana

description: Chromodoris africana Eliot, 1904
(Figure 4 B)
Material examined. Ten specimens. UL-YT70, TO, 18 Nov. 2011, 30m, 68mm; MB28-00 4443, ZWH, 0 2 Feb. 2012, 18m, 50mm, collected by S. Bruck; MHN-YT132, ZWH, 0 5 Feb. 2012, 17m, 24mm, collected by P. Velho; MB28-004472, ZRP, 0 7 Feb. 2012, 2m, 35mm; MB28-004492, ZGWS, 20 Feb. 2012, 20m, 62mm; MB28-004554, ZGWS, 0 2 Jun. 2012, 20m, 62mm; MB28-004793, ZWH, 11 Jan. 2014, 17m, 25mm; ZMBN94234, ZRP, 0 3 Feb. 2014, 1m, 60mm; MB28-0 0 4970, ZY, 27 Feb. 2015, 60m, 70mm, collected by J. Wright; MB28-004971, ZY, 27 Feb. 2015, 60m, 62mm, collected by J. Wright.
Habitats. Subtropical tidal reefs, rocky reefs, wrecks and tropical coral reefs.
Occurrences. Ponta do Ouro, Zavora, Nuarro and Vamizi Island.
Geographic distribution. Indian Ocean. Gulf of Oman (Fatemi & Attaran-Fariman 2015), Red Sea (Yonow 1989; Debelius 1996), Tanzania (Eliot 1905; Rudman 1977), South Africa (Gosliner 1987; King & Fraser 2014), Madagascar and Comoros Islands (Gosliner et al. 2008) and Mozambique (King & Fraser 2014).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 17, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Chromodoris boucheti Rudman 1982
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris boucheti

description: Chromodoris cf. boucheti Rudman, 1982
(Figure 4 C)
Material examined. Fifteen specimens. MHN-YT1005, VINR, 12 Aug. 2013, 15m, 34mm; MB28-004633, VINR, 12 Aug. 2013, 16m, 38mm; MB28-004632, VINR, 12 Aug. 2013, 16m, 40mm; MB28-004929, VINR, 12 Aug.
2013, 16m, 37mm; MB28-0 0 5051, VINR, 12 Aug. 2013, 16m, 36mm; MB28-005052, 2spcs., NGF, 29 Jun. 2014, 37m, 25 and 32mm; MB28-005053, NHR, 0 1 Jun. 2014, 9m, 20mm; MB28-005054, NSS, 0 2 Jun. 2014, 18m, 42mm; MB28-005055, NFA, 0 3 Jun. 2014, 22m, 34mm; ZMBN105085, 4spcs., VIPP, 15 May 2015, 20- 30m, 20- 32mm, collected by M. Malaquias and Y. Tibiriçá; MHN-YT1551, VIPP, 19 May 2015, 12m, 38mm, collected by M. Malaquias and Y. Tibiriçá; MB28-005056, NGU, 24 Apr. 2016, 22m, 32mm; UL-YT1609, NGU, 29 Apr. 2016, 24m, 31mm.
Habitats. Tropical coral reefs.
Occurrences. Nuarro and Vamizi Island.
Geographic distribution. Indo-west, central Pacific. French Polynesia, New Zealand, Solomon Islands (Gosliner et al. 2008), Papua New Guinea, Fiji, Vanuatu, Australia (Rudman 1982), New Caledonia, Philippines, Indonesia, Singapore, Maldives, Comoro Islands, South Africa, Madagascar (Gosliner et al. 2008), Tanzania (Debelius 1996) and Mozambique.
Remarks. Chromodoris boucheti is the accepted name for this species in the Indian Ocean. However, our preliminary analyses of the COI region showed genetic distance (p -distance) of only 0.5% between sequences of specimens of C. lochi Rudman, 1982 from the Pacific Ocean retrived from Genbank and specimens of C. boucheti from this study, suggesting that they might belong to the same species.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 17-18, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Chromodoris hamiltoni Rudman 1977
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris hamiltoni

description: Chromodoris hamiltoni Rudman, 1977
(Figure 4 D)
Material examined. Eight specimens. MB28-004646, 0 9 Dec. 2010, 12 m, 28mm; MB28-004769, VIP, 12 Aug. 2013, 3 m, 25mm; MB28-004922, ZGWS, 0 5 Jul. 2014, 17 m, 25mm; MHN-YT1429, ZA51, 27 Oct. 2014, 13 m, 34mm; MB28-004941, ZA51, 27 Oct. 2014, 13 m, 24mm; MB28-005005, ZA51, 12 Jun. 2015, 11 m, 22mm; MB28-005010, ZA51, 12 Jun. 2015, 11 m, 35mm; MB28-005015, ZWH, 12 Aug. 2015, 14 m, 34mm.
Habitats. Subtropical tidal reefs, rocky reefs and tropical coral reefs.
Occurrences. Ponta do Ouro, Zavora, Barra and Vilanculos.
Geographic distribution. Indian Ocean. Red Sea (Yonow 2012), Tanzania, Kenya (Rudman 1977; Gosliner 1987; King & Fraser 2014), South Africa and Madagascar (Gosliner 1987; Gosliner et al. 2008; King & Fraser 2014) and Mozambique (Rudman 1982; King & Fraser 2014).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 18, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Fabrication of surface enhanced raman scattering substrates by controlled assembly and morphology tuning of gold nanoparticles
Creators: name: De Silva Indrasekara, Agampodi Swarnapali
Publisher: name: No Publisher Supplied
Year: 2014

description: The design and fabrication of nanoparticles (NPs) and NP assemblies to sustain intense electromagnetic field enhancement for surface enhanced Raman scattering (SERS)-based imaging and sensing have recently gained significant attention. In SERS, the intrinsic optical properties of plasmonic NPs are used to overcome the relatively low Raman cross-sections and thereby increase sensitivity. Sharp features in anisotropic NPs and interparticle gaps within NP assemblies have been identified as the locations where the highest SERS enhancements can be achieved, also known as “hot spots”. Many attempts have been reported that deal with the bottom-up assembly of NPs to achieve highly reproducible, sensitive, and well characterized SERS substrates, but it still remains a challenge to attain monodisperse, highly reproducible “hot spots” and directional assembly.   The focus of this dissertation is to develop synthetic protocols for controlled engineering of NPs with SERS “hot spots”, and thereby to contribute to the advancement of SERS-based sensing and imaging applications. In this dissertation, the development of SERS substrates has evolved from dimers of spherical gold NPs (SP), to star-shaped gold NPs (ST), and finally to assembled superstructures of ST and SPs.   The kinetically controlled assembly of SPs into dimers was achieved by using Raman active dithiolated linker molecules, with the highest yield reported for this method to the best of our knowledge, leading to SERS tags with a reproducible SERS enhancement on the order of 105. NP dimers, surface-functionalized to target U8& glioblastoma cancer cells, demonstrated a fast, reliable, and selective SERS-based detection of the diseased cells that outperforms fluorescence.   The morphology of the STs was modified to possess longer and sharper spikes with a narrower tip curvature thereby increasing the electromagnetic field localization at the tips. SERS substrates were designed by periodically and reproducibly immobilizing STs on a planar substrate with high surface coverage and limited to no clustering, thus enabling femtomolar detection of organic analytes with an outstanding 109 SERS enhancement.   Finally, the core-satellite assemblies of ST with SPs were achieved through conjugation linker chemistry. These assemblies demonstrated SERS enhancement of two orders of magnitudes greater than isolated STs thereby improving the sensitivity of potential SERS-based imaging and sensing applications.
Additional file 2: of Toward a comprehensive evidence map of overview of systematic review methods: paper 1â  purpose, eligibility, search and data extraction
Creators: name: Lunny, Carole
name: Brennan, Sue
name: McDonald, Steve
name: McKenzie, Joanne
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Purposive search strategies. (DOCX 3.53Â kb)
Chromodoris mandapamensis Valdes, Mollo & Ortea 1999
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris mandapamensis

description: Chromodoris mandapamensis Valdés, Mollo & Ortea, 1999
(Figure 4 E)
Material examined. Two specimens. MHN-YT220, ZGWS, 19 Feb. 2012, 28 m, 24mm, collected by P. Velho; MB28-004931, ZSC, 0 8 Oct. 2014, 16 m, 20mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. Solomon Islands, Papua New Guinea, Myanmar (Gosliner et al. 2008), Thailand (Gosliner et al. 2008; Mehrotra & Scott 2015), India (Valdés et al. 1999), South Africa (Gosliner et al. 2008) and Mozambique.
Remarks. See remarks under Goniobranchus pruna (Gosliner 1994).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 18, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Applications of the mixed linear model in genome-wide association studies  and small RNA motif discovery
Creators: name: Diao, Liyang
Publisher: name: No Publisher Supplied
Year: 2014

description: If sheer number of papers published is indicative of anything, it suggests that the age of genome-wide association studies, or GWAS, is here to stay.  However, in spite of the influx of data, several issues remain, one of which is the presence of confounding factors caused by relatedness within the study sample.  This can cause many false positive results.  In recent years, the use of mixed linear models to correct for unknown types of relatedness, i.e. "cryptic relatedness", has been very popular.  While this model has been shown to be successful in some cases, here we address the feasibility of performing GWAS in a highly structured population such as Saccharomyces cerevisiae, and find that the inclusion of fixed local ancestry covariates can sometimes lend a study more power.    Furthermore, we explore the application of mixed linear models in a different type of biological problem of discovering motifs associated with active microRNAs.  While there exist several algorithms for miRNA motif discovery, only a few consider background sequence composition of the 3' UTR binding site in addition to seed sequence motif enrichment, which is known to factor into miNRA binding efficacy.  The methods that do account for 3' UTR sequence composition do so by rescoring motif counts based on the background UTR sequence in which it appears.  Though computationally efficient, these methods are unable to simultaneously compare both gene expression values and UTR sequence, which our method, named MixMir, is able to do, with favorable results.  When compared to the simple linear model, as well as existing motif discovery algorithms, MixMir is able to rank true motifs more highly in multiple data sets.  Such computational methods are biologically significant because although it is possible to sequence small RNAs in a sample, their expression may not be perfectly correlated with the size of their effect, which is what we observed.
MOESM1 of Interested consumers’ awareness of harmful chemicals in everyday products
Creators: name: Hartmann, Sabrina
name: Klaschka, Ursula
Publisher: name: Figshare
Year: 2017
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 1. Survey Questions in German.
Exalphus solangeae Souza & Monne 2014
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Exalphus
Exalphus solangeae

description: 30. Exalphus solangeae Souza & Monné, 2014: 21, fig. 4 Holotype, female
Type locality. Brazil, Amazonas: Tabatinga, VIII.1978, B. Silva
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 345, DOI: 10.5281/zenodo.250291
Chromodoris quadricolor
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Chromodoris
Chromodoris quadricolor

description: Chromodoris quadricolor (Rüppell & Leuckart, 1830)
(Figure 4 F)
Material examined. One specimen. MB28-005040, NSS, 23 Jul. 2016, 25m, 36mm. Habitats. Tropical coral reefs.
Occurrences. Nuarro.
Geographic distribution. Indian Ocean. Red Sea, Tanzania (Rudman 1982) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 18, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168