Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
Creators: name: Wang, Zhe
name: Emmerich, Andrew
name: Pillon, Nicolas J
name: Moore, Tim
name: Hemerich, Daiane
name: Cornelis, Marilyn C
name: Mazzaferro, Eugenia
name: Broos, Siacia
name: Ahluwalia, Tarunveer S
name: Bartz, Traci M
name: Bentley, Amy R
name: Bielak, Lawrence F
name: Chong, Mike
name: Chu, Audrey Y
name: Berry, Diane
name: Dorajoo, Rajkumar
name: Dueker, Nicole D
name: Kasbohm, Elisa
name: Feenstra, Bjarke
name: Feitosa, Mary F
name: Gieger, Christian
name: Graff, Mariaelisa
name: Hall, Leanne M
name: Haller, Toomas
name: Hartwig, Fernando P
name: Hillis, David A
name: Huikari, Ville
name: Heard-Costa, Nancy
name: Holzapfel, Christina
name: Jackson, Anne U
name: Johansson, Åsa
name: Jørgensen, Anja Moltke
name: Kaakinen, Marika A
name: Karlsson, Robert
name: Kerr, Kathleen F
name: Kim, Boram
name: Koolhaas, Chantal M
name: Kutalik, Zoltan
name: Lagou, Vasiliki
name: Lind, Penelope A
name: Lorentzon, Mattias
name: Lyytikäinen, Leo-Pekka
name: Mangino, Massimo
name: Metzendorf, Christoph
name: Monroe, Kristine R
name: Pacolet, Alexander
name: Pérusse, Louis
name: Pool, Rene
name: Richmond, Rebecca C
name: Rivera, Natalia V
name: Robiou-Du-Pont, Sebastien
name: Schraut, Katharina E
name: Schulz, Christina-Alexandra
name: Stringham, Heather M
name: Tanaka, Toshiko
name: Teumer, Alexander
name: Turman, Constance
name: Van Der Most, Peter J
name: Vanmunster, Mathias
name: Van Rooij, Frank JA
name: Van Vliet-Ostaptchouk, Jana V
name: Zhang, Xiaoshuai
name: Zhao, Jing-Hua
name: Zhao, Wei
name: Balkhiyarova, Zhanna
name: Balslev-Harder, Marie N
name: Baumeister, Sebastian E
name: Beilby, John
name: Blangero, John
name: Boomsma, Dorret I
name: Brage, Soren
name: Braund, Peter S
name: Brody, Jennifer A
name: Bruinenberg, Marcel
name: Ekelund, Ulf
name: Liu, Ching-Ti
name: Cole, John W
name: Collins, Francis S
name: Cupples, L Adrienne
name: Esko, Tõnu
name: Enroth, Stefan
name: Faul, Jessica D
name: Fernandez-Rhodes, Lindsay
name: Fohner, Alison E
name: Franco, Oscar H
name: Galesloot, Tessel E
name: Gordon, Scott D
name: Grarup, Niels
name: Hartman, Catharina A
name: Heiss, Gerardo
name: Hui, Jennie
name: Illig, Thomas
name: Jago, Russell
name: James, Alan
name: Joshi, Peter K
name: Jung, Taeyeong
name: Kähönen, Mika
name: Kilpeläinen, Tuomas O
name: Koh, Woon-Puay
name: Kolcic, Ivana
name: Kraft, Peter P
name: Kuusisto, Johanna
name: Launer, Lenore J
name: Li, Aihua
name: Linneberg, Allan
name: Luan, Jian'an
name: Vidal, Pedro Marques
name: Medland, Sarah E
name: Milaneschi, Yuri
name: Moscati, Arden
name: Musk, Bill
name: Nelson, Christopher P
name: Nolte, Ilja M
name: Pedersen, Nancy L
name: Peters, Annette
name: Peyser, Patricia A
name: Power, Christine
name: Raitakari, Olli T
name: Reedik, Mägi
name: Reiner, Alex P
name: Ridker, Paul M
name: Rudan, Igor
name: Ryan, Kathy
name: Sarzynski, Mark A
name: Scott, Laura J
name: Scott, Robert A
name: Sidney, Stephen
name: Siggeirsdottir, Kristin
name: Smith, Albert V
name: Smith, Jennifer A
name: Sonestedt, Emily
name: Strøm, Marin
name: Tai, E Shyong
name: Teo, Koon K
name: Thorand, Barbara
name: Tönjes, Anke
name: Tremblay, Angelo
name: Uitterlinden, Andre G
name: Vangipurapu, Jagadish
name: Van Schoor, Natasja
name: Völker, Uwe
name: Willemsen, Gonneke
name: Williams, Kayleen
name: Wong, Quenna
name: Xu, Huichun
name: Young, Kristin L
name: Yuan, Jian Min
name: Zillikens, M Carola
name: Zonderman, Alan B
name: Ameur, Adam
name: Bandinelli, Stefania
name: Bis, Joshua C
name: Boehnke, Michael
name: Bouchard, Claude
name: Chasman, Daniel I
name: Smith, George Davey
name: De Geus, Eco JC
name: Deldicque, Louise
name: Dörr, Marcus
name: Evans, Michele K
name: Ferrucci, Luigi
name: Fornage, Myriam
name: Fox, Caroline
name: Garland, Theodore
name: Gudnason, Vilmundur
name: Gyllensten, Ulf
name: Hansen, Torben
name: Hayward, Caroline
name: Horta, Bernardo L
name: Hyppönen, Elina
name: Jarvelin, Marjo-Riitta
name: Johnson, W Craig
name: Kardia, Sharon LR
name: Kiemeney, Lambertus A
name: Laakso, Markku
name: Langenberg, Claudia
name: Lehtimäki, Terho
name: Marchand, Loic Le
name: Lifelines Cohort Study
name: Magnusson, Patrik KE
name: Martin, Nicholas G
name: Melbye, Mads
name: Metspalu, Andres
name: Meyre, David
name: North, Kari E
name: Ohlsson, Claes
name: Oldehinkel, Albertine J
name: Orho-Melander, Marju
name: Pare, Guillaume
name: Park, Taesung
name: Pedersen, Oluf
name: Penninx, Brenda WJH
name: Pers, Tune H
name: Polasek, Ozren
name: Prokopenko, Inga
name: Rotimi, Charles N
name: Samani, Nilesh J
name: Sim, Xueling
name: Snieder, Harold
name: Sørensen, Thorkild IA
name: Spector, Tim D
name: Timpson, Nicholas J
name: Van Dam, Rob M
name: Van Der Velde, Nathalie
name: Van Duijn, Cornelia M
name: Vollenweider, Peter
name: Völzke, Henry
name: Voortman, Trudy
name: Waeber, Gérard
name: Wareham, Nicholas J
name: Weir, David R
name: Wichmann, Heinz-Erich
name: Wilson, James F
name: Hevener, Andrea L
name: Krook, Anna
name: Zierath, Juleen R
name: Thomis, Martine AI
name: Loos, Ruth JF
name: Hoed, Marcel Den
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/208/205/2138
/692/308/2056
/692/308/575
article

description: Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353
description: Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.