The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
Creators: name: Franklin, Hannah D.
name: Russell, Lucy L.
name: Peakman, Georgia
name: Greaves, Caroline V.
name: Bocchetta, Martina
name: Nicholas, Jennifer
name: Poos, Jackie
name: Convery, Rhian S.
name: Cash, David M.
name: Van Swieten, John
name: Jiskoot, Lize
name: Moreno, Fermin
name: Sanchez-Valle, Raquel
name: Borroni, Barbara
name: Laforce, Robert
name: Masellis, Mario
name: Tartaglia, Maria Carmela
name: Graff, Caroline
name: Galimberti, Daniela
name: Rowe, James B.
name: Finger, Elizabeth
name: Synofzik, Matthis
name: Vandenberghe, Rik
name: De Mendonça, Alexandre
name: Tagliavini, Fabrizio
name: Santana, Isabel
name: Ducharme, Simon
name: Butler, Chris
name: Gerhard, Alex
name: Levin, Johannes
name: Danek, Adrian
name: Otto, Markus
name: Sorbi, Sandro
name: Le Ber, Isabelle
name: Pasquier, Florence
name: Rohrer, Jonathan D.
name: Afonso, Sónia
name: Almeida, Maria Rosario
name: Anderl-Straub, Sarah
name: Andersson, Christin
name: Antonell, Anna
name: Archetti, Silvana
name: Arighi, Andrea
name: Balasa, Mircea
name: Barandiaran, Myriam
name: Bargalló, Nuria
name: Bartha, Robart
name: Bender, Benjamin
name: Benussi, Alberto
name: Bertoux, Maxime
name: Bertrand, Anne
name: Bessi, Valentina
name: Black, Sandra
name: Borrego-Ecija, Sergi
name: Bras, Jose
name: Brice, Alexis
name: Bruffaerts, Rose
name: Camuzat, Agnès
name: Cañada, Marta
name: Cantoni, Valentina
name: Caroppo, Paola
name: Castelo-Branco, Miguel
name: Colliot, Olivier
name: Cope, Thomas
name: Deramecourt, Vincent
name: De Arriba, María
name: Di Fede, Giuseppe
name: Díez, Alina
name: Duro, Diana
name: Fenoglio, Chiara
name: Ferrari, Camilla
name: Ferreira, Catarina B.
name: Fox, Nick
name: Freedman, Morris
name: Fumagalli, Giorgio
name: Funkiewiez, Aurélie
name: Gabilondo, Alazne
name: Gasparotti, Roberto
name: Gauthier, Serge
name: Gazzina, Stefano
name: Giaccone, Giorgio
name: Gorostidi, Ana
name: Greaves, Caroline
name: Guerreiro, Rita
name: Heller, Carolin
name: Hoegen, Tobias
name: Indakoetxea, Begoña
name: Jelic, Vesna
name: Karnath, Hans-Otto
name: Keren, Ron
name: Kuchcinski, Gregory
name: Langheinrich, Tobias
name: Lebouvier, Thibaud
name: Leitão, Maria João
name: Lladó, Albert
name: Lombardi, Gemma
name: Loosli, Sandra
name: Maruta, Carolina
name: Mead, Simon
name: Meeter, Lieke
name: Miltenberger, Gabriel
name: Van Minkelen, Rick
name: Mitchell, Sara
name: Moore, Katrina
name: Nacmias, Benedetta
name: Nelson, Annabel
name: Öijerstedt, Linn
name: Olives, Jaume
name: Ourselin, Sebastien
name: Padovani, Alessandro
name: Panman, Jessica
name: Papma, Janne M.
name: Pijnenburg, Yolande
name: Polito, Cristina
name: Premi, Enrico
name: Prioni, Sara
name: Prix, Catharina
name: Rademakers, Rosa
name: Redaelli, Veronica
name: Rinaldi, Daisy
name: Rittman, Tim
name: Rogaeva, Ekaterina
name: Rollin, Adeline
name: Rosa-Neto, Pedro
name: Rossi, Giacomina
name: Rossor, Martin
name: Santiago, Beatriz
name: Saracino, Dario
name: Sayah, Sabrina
name: Scarpini, Elio
name: Schönecker, Sonja
name: Seelaar, Harro
name: Semler, Elisa
name: Shafei, Rachelle
name: Shoesmith, Christen
name: Swift, Imogen
name: Tábuas-Pereira, Miguel
name: Tainta, Mikel
name: Taipa, Ricardo
name: Tang-Wai, David
name: Thomas, David L.
name: Thompson, Paul
name: Thonberg, Hakan
name: Timberlake, Carolyn
name: Tiraboschi, Pietro
name: Todd, Emily
name: Van Damme, Philip
name: Vandenbulcke, Mathieu
name: Veldsman, Michele
name: Verdelho, Ana
name: Villanua, Jorge
name: Warren, Jason
name: Wilke, Carlo
name: Woollacott, Ione
name: Wlasich, Elisabeth
name: Zetterberg, Henrik
name: Zulaica, Miren
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
Frontotemporal dementia
Familial
C9orf72
GRN
MAPT
RSMS
CDR® plus NACC FTLD
VBM

description: Abstract: Background: Although social cognitive dysfunction is a major feature of frontotemporal dementia (FTD), it has been poorly studied in familial forms. A key goal of studies is to detect early cognitive impairment using validated measures in large patient cohorts. Methods: We used the Revised Self-Monitoring Scale (RSMS) as a measure of socioemotional sensitivity in 730 participants from the genetic FTD initiative (GENFI) observational study: 269 mutation-negative healthy controls, 193 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. All participants underwent the standardised GENFI clinical assessment including the ‘CDR® plus NACC FTLD’ scale and RSMS. The RSMS total score and its two subscores, socioemotional expressiveness (EX score) and modification of self-presentation (SP score) were measured. Volumetric T1-weighted magnetic resonance imaging was available from 377 mutation carriers for voxel-based morphometry (VBM) analysis. Results: The RSMS was decreased in symptomatic mutation carriers in all genetic groups but at a prodromal stage only in the C9orf72 (for the total score and both subscores) and GRN (for the modification of self-presentation subscore) groups. RSMS score correlated with disease severity in all groups. The VBM analysis implicated an overlapping network of regions including the orbitofrontal cortex, insula, temporal pole, medial temporal lobe and striatum. Conclusions: The RSMS indexes socioemotional impairment at an early stage of genetic FTD and may be a suitable outcome measure in forthcoming trials.