cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants
Creators: name: Uematsu, Masaaki
name: Nishimura, Taki
name: Sakamaki, Yuriko
name: Yamamoto, Hayashi
name: Mizushima, Noboru
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology

description: Macroautophagy/autophagy, which is one of the main degradation systems in the cell, is mediated by a specialized organelle, the autophagosome. Purification of autophagosomes before fusion with lysosomes is important for both mechanistic and physiological studies of the autophagosome. Here, we report a simple method to accumulate undigested autophagosomes. Overexpression of the autophagosomal Qa-SNARE STX17 (syntaxin 17) lacking the N-terminal domain (NTD) or N-terminally tagged GFP-STX17 causes accumulation of autophagosomes. A HeLa cell line, which expresses GFP-STX17ΔNTD or full-length GFP-STX17 under the control of the tetracycline-responsive promoter, accumulates a large number of undigested autophagosomes devoid of lysosomal markers or early autophagy factors upon treatment with doxycycline. Using this inducible cell line, nascent autophagosomes can be easily purified by OptiPrep density-gradient centrifugation and immunoprecipitation. This novel method should be useful for further characterization of nascent autophagosomes.
The Effects of Negative Feedback on Intention to Improve Efficiency of Job and Work Performance of Generation Y
Creators: name: Bussakorn Khumhome
name: Mullika Sungsanit
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2019
Subjects: Negative feedback
intention to improve the job efficiency
generation y

description: Humanities, Arts and Social Sciences Studies, 19, 3, 628-648
An Investigation of International Tourists on Tourist Satisfaction, Tourist Experience and Destination Loyalty
Creators: name: Comtas Tassawa
name: Jantima Banjongprasert
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2019
Subjects: Tourist experience
cognitive satisfaction
affective satisfaction
destination loyalty

description: Humanities, Arts and Social Sciences Studies, 19, 3, 649-674
Employess' Organizational Commitment: A Study of Navanakorn Industrial in Phatumtani Province, Thailand
Creators: name: Khukrit Silalaiy
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2019
Subjects: Commitment
organization
employee
Navanakorn Industrial Estate
Phathumtani

description: Humanities, Arts and Social Sciences Studies, 19, 3, 675-689
MOESM1 of Cost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma in US
Creators: name: Zafari, Zafar
name: Sadatsafavi, Mohsen
name: J. Mark FitzGerald
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1: Appendix S1. Estimating the transition probabilities for add-on therapy with omalizumab. Appendix S2. Estimating the medication costs per level of control.
Etale representations for reductive algebraic groups with factors $Sp_n$ or $SO_n$
Creators: name: Burde, Dietrich
name: Globke, Wolfgang
name: Minchenko, Andrei
Publisher: name: arXiv
Year: 2017
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: A complex vector space $V$ is an étale $G$-module if $G$ acts rationally on $V$ with a Zariski-open orbit and $\dim G=\dim V$. Such a module is called super-étale if the stabilizer of a point in the open orbit is trivial. Popov proved that reductive algebraic groups admitting super-étale modules are special algebraic groups. He further conjectured that a reductive group admitting a super-étale module is always isomorphic to a product of general linear groups. In light of previously available examples, one can conjecture more generally that in such a group all simple factors are either $SL_n$ for some $n$ or $Sp_2$. We show that this is not the case by constructing a family of super-étale modules for groups with a factor $Sp_n$ for arbitrary $n\geq1$. A similar construction provides a family of étale modules for groups with a factor $SO_n$, which shows that groups with étale modules with non-trivial stabilizer are not necessarily special. Both families of examples are somewhat surprising in light of the previously known examples of étale and super-étale modules for reductive groups. Finally, we show that the exceptional groups $F_4$ and $E_8$ cannot appear as simple factors in the maximal semisimple subgroup of an arbitrary Lie group with a linear étale representation.
Born--Infeld-type electrodynamics and magnetic black holes
Creators: name: Kruglov, S. I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate a Born--Infeld-type model of nonlinear electrodynamics, possessing three parameters, coupled with general relativity. As a particular case Born--Infeld electrodynamics is reproduced. There is no singularity of the electric field at the centre of point-like charged particles and self-energy of charges is finite in this model. The magnetized black hole is studied and solutions are obtained. We demonstrate that for some parameters of the model the black hole is regular. We find the asymptotic of the metric and mass functions at $r\rightarrow\infty$ and $r\rightarrow 0$, and corrections to the Reissner--Nordström solution. Thermodynamics of black holes is investigated. We calculate the Hawking temperature of black holes and show that black holes are not stable and there are phase transitions in the model under consideration.
description: 15 pages, 6 figures, corrected Eq. (26) and Fig. 6
Human Capital Development Affecting to Sustainable Organization of Thai SMEs Firms in Phetchaburi Province
Creators: name: Taninrat Rattanapongpinyo
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2019
Subjects: Sustainable Organization
Human CapitalDevelopment
OrganizationFactors
Thai SMEs

description: Humanities, Arts and Social Sciences Studies, 19, 3, 690-707
Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
Creators: name: Cristofani, Riccardo
name: Crippa, Valeria
name: Rusmini, Paola
name: Cicardi, Maria Elena
name: Meroni, Marco
name: Licata, Nausicaa V.
name: Sala, Gessica
name: Giorgetti, Elisa
name: Grunseich, Christopher
name: Galbiati, Mariarita
name: Piccolella, Margherita
name: Messi, Elio
name: Ferrarese, Carlo
name: Carra, Serena
name: Poletti, Angelo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent misfolded protein toxicity, cells activate a protein quality control (PQC) system composed of chaperones and degradative pathways (proteasome and autophagy). Inefficient activation of the PQC system results in misfolded protein accumulation that ultimately leads to neuronal cell death, while efficient macroautophagy/autophagy-mediated degradation of aggregating proteins is beneficial. The latter relies on an active retrograde transport, mediated by dynein and specific chaperones, such as the HSPB8-BAG3-HSPA8 complex. Here, using cellular models expressing aggregate-prone proteins involved in SBMA and ALS, we demonstrate that inhibition of dynein-mediated retrograde transport, which impairs the targeting to autophagy of misfolded species, does not increase their aggregation. Rather, dynein inhibition correlates with a reduced accumulation and an increased clearance of mutant ARpolyQ, SOD1, truncated TARDBP/TDP-43 and expanded polyGP C9ORF72 products. The enhanced misfolded protein clearance is mediated by the proteasome, rather than by autophagy and correlates with the upregulation of the HSPA8 cochaperone BAG1. In line, overexpression of BAG1 increases the proteasome-mediated clearance of these misfolded proteins. Our data suggest that when the misfolded proteins cannot be efficiently transported toward the perinuclear region of the cells, where they are either degraded by autophagy or stored into the aggresome, the cells activate a compensatory mechanism that relies on the induction of BAG1 to target the HSPA8-bound cargo to the proteasome in a dynein-independent manner.
Additional file 2: of Development of a rapid point-of-care patient reported outcome measure for cataract surgery in India
Creators: name: Ehrlich, Joshua
name: Frank, Charlie
name: Smiley, Josiah
name: Hong-Gam Le
name: Sanil Joseph
name: Schilling, Stephen
name: Stagg, Brian
name: Stein, Joshua
name: R. Ravindran
name: Aravind Haripriya
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary tables from Rasch Analysis. These tables report for each of the 12 survey items: the average visual functioning estimates for each response category; category thresholds; and misfit statistics. (DOCX 19Â kb)
BY-COVID D8.5 Policy Brief II: Research data infrastructure for sustainable global pandemic preparedness
Creators: name: Maccallum, Peter
name: Hermjakob, Henning
name: Harrison, Elaine
name: Tseng, Yun-Yun
Publisher: name: Zenodo
Year: 2024
Subjects: BY-COVID
COVID-19
Research Infrastructure
Pandemic Preparedness
Policy brief

description: This second Policy Brief from the BY-COVID project supplements the first, on ‘Open data to support pandemic preparedness’, by addressing the role of Research Infrastructures in the global pandemic preparedness landscape.

The BY-COVID project has built data partnerships to support pathogen research and pandemic response. The project brought together researchers, infrastructure and database providers and policymakers, initially around COVID-19 resources but gradually developing a vision for a general capability extensible to all pathogens.

Core to the project have been the ten participating European Research Infrastructures. They brought established services to build on, expertise to develop new solutions and have the potential to provide long-term hosts for knowledge and new services.

Through the project and consultation with our partners we have developed a picture of what is required in a future pandemic response architecture. The network of international reference and deposition databases are at the heart to support data sharing. Portals and analysis environments developed to support the COVID-19 response can be developed for all pathogens in partnership with infrastructure providers. Development of data standards, reusable analytic tools and communities of practice can be supported by the Research Infrastructures.

Here, we offer recommendations for policymakers and other stakeholders: that consolidated resources for pathogen data are developed at the international and national levels; that pathogen researchers partner with the e-Infrastructures to ensure technologies are aligned and capacity for outbreak response is available; and that the Research Infrastructures maintain pathogens communities of practice in preparation for a future pandemic.
Equidimensional adic eigenvarieties for groups with discrete series
Creators: name: Gulotta, Daniel R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11F85, 11S80

description: We extend Urban's construction of eigenvarieties for reductive groups $G$ such that $G(\mathbb{R})$ has discrete series to include characteristic $p$ points at the boundary of weight space. In order to perform this construction, we define a notion of "locally analytic" functions and distributions on a locally $\mathbb{Q}_p$-analytic manifold taking values in a complete Tate $\mathbb{Z}_p$-algebra in which $p$ is not necessarily invertible. Our definition agrees with the definition of locally analytic distributions on $p$-adic Lie groups given by Johansson and Newton.
description: 32 pages, fixed issues with weights in section 5
Why the mean anomaly at epoch is not used in tests of non-Newtonian gravity?
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: The mean anomaly at epoch $η$ is one of the standard six Keplerian orbital elements in terms of which the motion of the two-body problem is parameterized. Along with the argument of pericenter $ω$, $η$ experiences long-term rates of change induced, among other things, by general relativity and several modified models of gravity. Thus, in principle, it may be fruitfully adopted together with $ω$ in several tests of post-Newtonian gravity performed with astronomical and astrophysical binary systems. This would allow to enhance the gravitational signature one is interested in and to disentangle some competing disturbing effects acting as sources of systematic bias. Nonetheless, for some reasons unknown to the present author, $η$ has never been used so far by astronomers in actual data reductions. This note aims to raise interest in the community about the possible practical use of such an orbital element or, at least, to induce experts in astronomical data processing to explicitly make clear if it is not possible to use $η$ for testing gravitational models and, in this case, why.
description: LaTex2e, 7 pages, no figures, no tables
Scale anomaly of a Lifshitz scalar: a universal quantum phase transition to discrete scale invariance
Creators: name: Brattan, Daniel K.
name: Ovdat, Omrie
name: Akkermans, Eric
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate the existence of a universal transition from a continuous scale invariant phase to a discrete scale invariant phase for a class of one-dimensional quantum systems with anisotropic scaling symmetry between space and time. These systems describe a Lifshitz scalar interacting with a background potential. The transition occurs at a critical coupling $λ_{c}$ corresponding to a strongly attractive potential.
description: 6 pages, 3 figures + 3 pages supplementary material; v2: minor typos corrected, additional text of published version added
title: Vierte Satzung zur Änderung der Prüfungsordnung für die Bachelorstudiengänge International Business Studies, Wirtschaftsinformatik, Wirtschaftswissenschaften der Fakultät für Wirtschaftswissenschaften an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Additional file 3: Table S3. of Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data
Creators: name: Ceballos, Francisco
name: Hazelhurst, Scott
name: MichĂ¨Le Ramsay
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Means and standard deviations of number of ROH, ROH size and total sum of ROH for different populations, technologies and allowed heterozygous SNPs per ROH (DOCX 35Â kb)
Gyrokinetic Theory of Low-frequency Electromagnetic Waves in Finite-$β$ Anisotropic Plasmas
Creators: name: Chen, Haotian
name: Chen, Liu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present a gyrokinetic theory for the electromagnetic waves and instabilities with frequencies much lower than the ion cyclotron frequency in finite-$β$ anisotropic uniform plasmas. Here, $β$ is the ratio between plasma and magnetic pressures. Kinetic effects due to both the finite Larmor radii and wave-particle resonances are fully kept in the analysis. Corresponding linear dispersion relation and wave polarizations, valid for general $β$ value and perpendicular wavelength, are then specifically derived for a bi-Maxwellian plasma. Analytic expressions for the criteria of kinetic firehose and mirror instabilities are also given. The mode frequency, stability, and wave polarization of a broad spectrum of normal modes are then investigated numerically in a systematic study over a set of parameters. Our study clearly demonstrates that, due to the finite ion Larmor radius effect, the ion-sound wave, mirror mode, and shear Alfven wave are intrinsically coupled.
A robotic vision system to measure tree traits
Creators: name: Tabb, Amy
name: Medeiros, Henry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: The autonomous measurement of tree traits, such as branching structure, branch diameters, branch lengths, and branch angles, is required for tasks such as robotic pruning of trees as well as structural phenotyping. We propose a robotic vision system called the Robotic System for Tree Shape Estimation (RoTSE) to determine tree traits in field settings. The process is composed of the following stages: image acquisition with a mobile robot unit, segmentation, reconstruction, curve skeletonization, conversion to a graph representation, and then computation of traits. Quantitative and qualitative results on apple trees are shown in terms of accuracy, computation time, and robustness. Compared to ground truth measurements, the RoTSE produced the following estimates: branch diameter (root mean-squared error $2.97$ mm), branch length (root mean-squared error $136.92$ mm), and branch angle (mean-squared error $31.07$ degrees). The average run time was $8.47$ minutes when the voxel resolution was $3$ mm$^3$.
description: 9 pages, IEEE/RSJ IROS 2017 conference paper, added Erratum 11/1/2021
title: Sechste Satzung zur Änderung der Prüfungsordnung für die Masterstudiengänge Betriebswirtschaftslehre, International Business Studies, International Economics and Management, Management Information Systems, Wirtschaftsinformatik, Wirtschaftspädagogik, Wirtschaftspädagogik - Lehramt Berufskollegs der Fakultät für Wirtschaftswissenschaften an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy
Creators: name: Shen, Ming
name: Jiang, Yi
name: Guan, Zhiqiang
name: Cao, Yan
name: Li, Liechuan
name: Liu, Honglin
name: Sun, Shao-chen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death via some novel signaling effectors is engaged in FSH-mediated GCs protection against oxidative damage. The decline in GCs viability caused by oxidant injury was remarkably reduced following FSH treatment, along with impaired macroautophagic/autophagic flux under conditions of oxidative stress both in vivo and in vitro. Blocking of autophagy displayed similar levels of suppression in oxidant-induced cell death compared with FSH treatment, but FSH did not further improve survival of GCs pretreated with autophagy inhibitors. Further investigations revealed that activation of the phosphoinositide 3-kinase (PI3K)-AKT-MTOR (mechanistic target of rapamycin [serine/threonine kinase]) signaling pathway was required for FSH-mediated GCs survival from oxidative stress-induced autophagy. Additionally, the FSH-PI3K-AKT axis also downregulated the autophagic response by targeting FOXO1, whereas constitutive activation of FOXO1 in GCs not only abolished the protection from FSH, but also emancipated the autophagic process, from the protein level of MAP1LC3B-II to autophagic gene expression. Furthermore, FSH inhibited the production of acetylated FOXO1 and its interaction with Atg proteins, followed by a decreased level of autophagic cell death upon oxidative stress. Taken together, our findings suggest a new mechanism involving FSH-FOXO1 signaling in defense against oxidative damage to GCs by restraining autophagy, which may be a potential avenue for the clinical treatment of anovulatory disorders.
The primordial deuterium abundance at z = 2.504 from a high signal-to-noise spectrum of Q1009+2956
Creators: name: Zavarygin, E. O.
name: Webb, J. K.
name: Dumont, V.
name: Riemer-Sørensen, S.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The spectrum of the $z_{\rm em} = 2.63$ quasar Q1009+2956 has been observed extensively on the Keck telescope. The Lyman limit absorption system $z_{\rm abs} = 2.504$ was previously used to measure D/H by Burles & Tytler using a spectrum with signal to noise approximately 60 per pixel in the continuum near Ly α at $z_{\rm abs} = 2.504$. The larger dataset now available combines to form an exceptionally high signal to noise spectrum, around 147 per pixel. Several heavy element absorption lines are detected in this LLS, providing strong constraints on the kinematic structure. We explore a suite of absorption system models and find that the deuterium feature is likely to be contaminated by weak interloping Ly α absorption from a low column density H I cloud, reducing the expected D/H precision. We find D/H = $2.48^{+0.41}_{-0.35}\times10^{-5}$ for this system. Combining this new measurement with others from the literature and applying the method of Least Trimmed Squares to a statistical sample of 15 D/H measurements results in a "reliable" sample of 13 values. This sample yields a primordial deuterium abundance of (D/H)$_{\rm p} = (2.545 \pm 0.025)\times10^{-5}$. The corresponding mean baryonic density of the Universe is $Ω_{\rm b}h^2 = 0.02174\pm0.00025$. The quasar absorption data is of the same precision as, and marginally inconsistent with, the 2015 CMB Planck (TT+lowP+lensing) measurement, $Ω_{\rm b}h^2 = 0.02226\pm0.00023$. Further quasar and more precise nuclear data are required to establish whether this is a random fluctuation.
description: accepted by MNRAS, 18 pages, 12 figures, 6 tables
title: Satzung zur Änderung der Prüfungsordnung für den Masterstudiengang Taxation, Accounting and Finance der Fakultät für Wirtschaftswissenschaften an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Lie models for nilpotent spaces
Creators: name: Félix, Yves
name: Moreno-Fernández, José
name: Tanré, Daniel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55P62, 55U15, 16E45

description: Let $(L,d)$ be a differential graded Lie algebra, where $L=L(V)$ is free as graded Lie algebra and $V=V_{\geq 0}$ is a finite type graded vector space. We prove that the injection of $(L,d)$ into its completion $(\widehat{L},d)$ is a quasi-isomorphism if and only if $H(L,d)$ is a finite type pronilpotent graded Lie algebra. As a consequence, we obtain an equivalence between graded Lie models for nilpotent spaces in rational homotopy theory.
Evaluation of IoT Self-healing Mechanisms using Fault-Injection in Message Brokers
Creators: name: Duarte, Miguel
name: Dias, João Pedro
name: Ferreira, Hugo Sereno
name: Restivo, André
Publisher: name: arXiv
Year: 2022
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The widespread use of Internet-of-Things (IoT) across different application domains leads to an increased concern regarding their dependability, especially as the number of potentially mission-critical systems becomes considerable. Fault-tolerance has been used to reduce the impact of faults in systems, and their adoption in IoT is becoming a necessity. This work focuses on how to exercise fault-tolerance mechanisms by deliberately provoking its malfunction. We start by describing a proof-of-concept fault-injection add-on to a commonly used publish/subscribe broker. We then present several experiments mimicking real-world IoT scenarios, focusing on injecting faults in systems with (and without) active self-healing mechanisms and comparing their behavior to the baseline without faults. We observe evidence that fault-injection can be used to (a) exercise in-place fault-tolerance apparatus, and (b) detect when these mechanisms are not performing nominally, providing insights into enhancing in-place fault-tolerance techniques.
description: 8 pages
title: Satzung zur Änderung der Prüfungsordnung für die Bachelorstudiengänge International Business Studies, Wirtschaftsinformatik, Wirtschaftswissenschaften der Fakultät für Wirtschaftswissenschaften an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
title: Zweite Satzung zur Änderung der Prüfungsordnung für die Masterstudiengänge Betriebswirtschaftslehre, International Business Studies, International Economics and Management, Management Information Systems, Wirtschaftsinformatik, Wirtschaftspädagogik, Wirtschaftspädagogik - Lehramt Berufskollegs der Fakultät für Wirtschaftswissenschaften an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Additional file 2: Table S2. of The Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations, Outcomes (REACH-OUT) study: real-world clinical practice in schizophrenia
Creators: name: Kruti Joshi
name: Mao, Lian
name: Biondi, David
name: Millet, Robert
Publisher: name: figshare
Year: 2018
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Outpatient utilization at enrollment and at the 12-month follow-up visit. (DOCX 14Â kb)
title: Gleichstellungsplan der Fakultät für Wirtschaftswissenschaften zur Gleichstellung von Frauen und Männern an der Universität Paderborn
title: vom 20. Januar 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Additional file 3: of Tools for a systematic appraisal of integrated community-based approaches to prevent childhood obesity
Creators: name: K. Mantziki
name: C. Renders
name: M. Westerman
name: J. Mayer
name: J. Borys
name: J. Seidell
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Computational Biology

description: Analysis grid of the OPEN tool. (DOCX 56 kb)
School-Based Depression Prevention Interventions
Creators: name: Berny, Lauren M.
name: Chinn, Lisa K
name: Day, Elizabeth
name: Schweer-Collins, Maria
name: Grant, Sean
name: Steinka-Fry, Katarzyna
name: Tanner-Smith, Emily
name: Golfen, Joe
name: Trevino, Shaina
Publisher: name: OSF
Year: 2023
Subjects: depression
evidence synthesis
prevention
research synthesis

description: OSF project folder for: https://hedcoinstitute.uoregon.edu/depression-prevention-review
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Creators: name: Campos, Juliane C.
name: Queliconi, Bruno B.
name: Bozi, Luiz H. M.
name: Bechara, Luiz R. G.
name: Dourado, Paulo M. M.
name: Andres, Allen M.
name: Jannig, Paulo R.
name: Gomes, Kátia M. S.
name: Zambelli, Vanessa O.
name: Rocha-Resende, Cibele
name: Guatimosim, Silvia
name: Brum, Patricia C.
name: Mochly-Rosen, Daria
name: Gottlieb, Roberta A.
name: Kowaltowski, Alicia J.
name: Ferreira, Julio C. B.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Cancer

description: We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control, bioenergetics and oxidative damage in a post-myocardial infarction-induced heart failure animal model. We found that failing hearts displayed reduced autophagic flux depicted by accumulation of autophagy-related markers and loss of responsiveness to chloroquine treatment at 4 and 12 wk after myocardial infarction. These changes were accompanied by accumulation of fragmented mitochondria with reduced O2 consumption, elevated H2O2 release and increased Ca2+-induced mitochondrial permeability transition pore opening. Of interest, disruption of autophagic flux was sufficient to decrease cardiac mitochondrial function in sham-treated animals and increase cardiomyocyte toxicity upon mitochondrial stress. Importantly, 8 wk of exercise training, starting 4 wk after myocardial infarction at a time when autophagy and mitochondrial oxidative capacity were already impaired, improved cardiac autophagic flux. These changes were followed by reduced mitochondrial number:size ratio, increased mitochondrial bioenergetics and better cardiac function. Moreover, exercise training increased cardiac mitochondrial number, size and oxidative capacity without affecting autophagic flux in sham-treated animals. Further supporting an autophagy mechanism for exercise-induced improvements of mitochondrial bioenergetics in heart failure, acute in vivo inhibition of autophagic flux was sufficient to mitigate the increased mitochondrial oxidative capacity triggered by exercise in failing hearts. Collectively, our findings uncover the potential contribution of exercise in restoring cardiac autophagy flux in heart failure, which is associated with better mitochondrial quality control, bioenergetics and cardiac function.
EXPLORING AN ALTERNATIVE TECHNOLOGY FOR MANUFACTURING ELECTRONICS FOR EXTREME TEMPERATURES
Creators: name: Patel, Mital
Publisher: name: Digital Repository at the University of Maryland
Year: 2023
Subjects: subject: Mechanical engineering
subject: FOS: Mechanical engineering
subject: diamond
subject: electronics packaging
subject: graphene
subject: high temperature electronics

description: Within our increasingly digital world, there is a demand to integrate electronics into every industry to take advantage of applications in communication, optimization, and artificial intelligence. Relatively untapped areas for electronics implementation are the extreme environments where high temperatures (>300°C) are present. These environments are common within energy, automotive, and aerospace industry es. Current high temperature technologies limit reliable use of electronics to ~200°C. Emerging technologies, such as transient liquid phase (TLP) bonding, copper sintering, and thick films, have not yet demonstrated resilient operation above 300°C. Possessing various remarkable properties, diamond is a promising material that can be used in manufacturing electronic devices operable well above 500°C. Graphene and graphite additionally can serve as conductive material for circuitry or other electronic elements. The compatibility and versatility of these three materials demonstrate the potential for robust, all-carbon electronics for high temperature applications. Chemical vapor deposition (CVD), the predominant method of synthesizing diamond for electronics, involves very costly, long processes at extreme temperatures. A relatively underdeveloped, alternative method utilizes the pyrolysis of polymer precursors into diamond. This study aims to further explore this method using Poly(naphthalene-co-hydridocarbyne) (PNHC). The polymer synthesis, processing, and pyrolysis have been performed here, and the process parameters and outcomes at each step have been documented. Native graphite and graphene growth on diamond surfaces allows for the integration of conductive material on insulating diamond. Four known methods of diamond graphitization, assisted with the metal catalysts nickel, copper, and iron, have also been applied to support the fabrication of carbon-based electronics. Ultimately in this study, the synthesis of diamond has been unsuccessful, but multi-layer graphene has been grown on polycrystalline diamond with high sheet carrier concentration and mobility values of 1.0*1015 cm-2 and 629.1 cm2 Vs-1, respectively.
First-order metal-insulator transitions in the extended Hubbard model due to self-consistent screening of the effective interaction
Creators: name: Schüler, M.
name: van Loon, E. G. C. P.
name: Katsnelson, M. I.
name: Wehling, T. O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: While the Hubbard model is the standard model to study Mott metal-insulator transitions, it is still unclear to which extent it can describe metal-insulator transitions in real solids, where non-local Coulomb interactions are always present. By using a variational principle, we clarify this issue for short- and long-ranged non-local Coulomb interactions for half-filled systems on bipartite lattices. We find that repulsive non-local interactions generally stabilize the Fermi-liquid regime. The metal-insulator phase boundary is shifted to larger interaction strengths to leading order linearly with non-local interactions. Importantly, non-local interactions can raise the order of the metal-insulator transition. We present a detailed analysis of how the dimension and geometry of the lattice as well as the temperature determine the critical non-local interaction leading to a first-order transition: for systems in more than two dimensions with non-zero density of states at the Fermi energy the critical non-local interaction is arbitrarily small; otherwise it is finite.
description: 10 pages, 11 figures
Phase transition effects on the dynamical stability of hybrid neutron stars
Creators: name: Pereira, Jonas P.
name: Flores, César V.
name: Lugones, Germán
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study radial oscillations of hybrid non-rotating neutron stars composed by a quark matter core and hadronic external layers. At first, we physically deduce the junction conditions that should be imposed between two any phases in these systems when perturbations take place. Then we compute the oscillation spectrum focusing on the effects of slow and rapid phase transitions at the quark-hadron interface. We use a generic MIT bag model for quark matter and a relativistic mean field theory for hadronic matter. In the case of rapid transitions at the interface we find a general relativistic version of the reaction mode which has similar properties as its classical counterpart. We also show that the usual static stability condition $\partial M/\partial ρ_c\geq 0$, where $ρ_c$ is the central density of a star whose total mass is $M$, remains always true for rapid transitions but breaks down in general for slow transitions. In fact, for slow transitions we find that the frequency of the fundamental mode can be a real number (indicating stability) even for some branches of stellar models that verify $\partial M/\partial ρ_c \leq 0$. Thus, when secular instabilities are suppressed, as expected below some critical stellar rotation rate, it would be possible the existence of twin or even triplet stars with the same gravitational mass but different radii, with one of the counterparts having $\partial M/\partial ρ_c \leq 0$. We explore some astrophysical consequences of these results.
description: 14 pages, 15 figures. Minor changes. Version accepted for publication in ApJ
Additional file 2: Table S2. of Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data
Creators: name: Ceballos, Francisco
name: Hazelhurst, Scott
name: MichĂ¨Le Ramsay
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Pearson correlations (y-axis) of number of ROH, mean ROH size and mean sum of ROH between array data with 1 heterozygous allowed per RHO and WGS with 1 to 5 heterozygous SNP allowed per ROH (x-axis). (DOCX 28Â kb)
Spin-state-controlled chemi-ionization reactions between metastable helium atoms and ground-state lithium atoms
Creators: name: Sixt, Tobias
name: Stienkemeier, Frank
name: Dulitz, Katrin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate the control of $^4$He(2$^3$S$_1$)-$^7$Li(2$^2$S$_{1/2}$) chemi-ionization reactions by all-optical electron-spin-state preparation of both atomic species prior to the collision process. Our results demonstrate that chemi-ionization is strongly suppressed (enhanced) for non-spin-conserving (spin-conserving) collisions at thermal energies. These findings are in good agreement with a model based on spin angular momentum coupling of the prepared atomic states to the quasi-molecular states. Small deviations from the model indicate the contribution of the $^4Σ^+$ channel to the reaction rate which is in violation of spin conservation.
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Creators: name: C. Campos, Juliane
name: B. Queliconi, Bruno
name: H. M. Bozi, Luiz
name: R. G. Bechara, Luiz
name: M. M. Dourado, Paulo
name: M. Andres, Allen
name: R. Jannig, Paulo
name: Gomes, Kátia M. S.
name: O. Zambelli, Vanessa
name: Rocha-Resende, Cibele
name: Guatimosim, Silvia
name: C. Brum, Patricia
name: Mochly-Rosen, Daria
name: A. Gottlieb, Roberta
name: J. Kowaltowski, Alicia
name: C. B. Ferreira, Julio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Cancer

description: We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control, bioenergetics and oxidative damage in a post-myocardial infarction-induced heart failure animal model. We found that failing hearts displayed reduced autophagic flux depicted by accumulation of autophagy-related markers and loss of responsiveness to chloroquine treatment at 4 and 12 wk after myocardial infarction. These changes were accompanied by accumulation of fragmented mitochondria with reduced O2 consumption, elevated H2O2 release and increased Ca2+-induced mitochondrial permeability transition pore opening. Of interest, disruption of autophagic flux was sufficient to decrease cardiac mitochondrial function in sham-treated animals and increase cardiomyocyte toxicity upon mitochondrial stress. Importantly, 8 wk of exercise training, starting 4 wk after myocardial infarction at a time when autophagy and mitochondrial oxidative capacity were already impaired, improved cardiac autophagic flux. These changes were followed by reduced mitochondrial number:size ratio, increased mitochondrial bioenergetics and better cardiac function. Moreover, exercise training increased cardiac mitochondrial number, size and oxidative capacity without affecting autophagic flux in sham-treated animals. Further supporting an autophagy mechanism for exercise-induced improvements of mitochondrial bioenergetics in heart failure, acute in vivo inhibition of autophagic flux was sufficient to mitigate the increased mitochondrial oxidative capacity triggered by exercise in failing hearts. Collectively, our findings uncover the potential contribution of exercise in restoring cardiac autophagy flux in heart failure, which is associated with better mitochondrial quality control, bioenergetics and cardiac function.
Astronomical random numbers for quantum foundations experiments
Creators: name: Leung, Calvin
name: Brown, Amy
name: Nguyen, Hien
name: Friedman, Andrew S.
name: Kaiser, David I.
name: Gallicchio, Jason
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Photons from distant astronomical sources can be used as a classical source of randomness to improve fundamental tests of quantum nonlocality, wave-particle duality, and local realism through Bell's inequality and delayed-choice quantum eraser tests inspired by Wheeler's cosmic-scale Mach-Zehnder interferometer gedankenexperiment. Such sources of random numbers may also be useful for information-theoretic applications such as key distribution for quantum cryptography. Building on the design of an "astronomical random-number generator" developed for the recent "cosmic Bell" experiment [Handsteiner et al., Phys. Rev. Lett. 118, 060401 (2017)], in this paper we report on the design and characterization of a device that, with 20-nanosecond latency, outputs a bit based on whether the wavelength of an incoming photon is greater than or less than 700 nm. Using the one-meter telescope at the Jet Propulsion Laboratory (JPL) Table Mountain Observatory, we generated random bits from astronomical photons in both color channels from 50 stars of varying color and magnitude, and from 12 quasars with redshifts up to $z = 3.9$. With stars, we achieved bit rates of $\sim 1 \times 10^6$ Hz / m$^2$, limited by saturation for our single-photon detectors, and with quasars of magnitudes between 12.9 and 16, we achieved rates between $\sim 10^2$ and $2 \times 10^3$ Hz /m$^2$. For bright quasars, the resulting bitstreams exhibit sufficiently low amounts of statistical predictability as quantified by the mutual information. In addition, a sufficiently high fraction of bits generated are of true astronomical origin in order to address both the locality and freedom-of-choice loopholes when used to set the measurement settings in a test of the Bell-CHSH inequality.
description: 17 pages, 12 figures. References added and minor edits to match published version
Gradient flow dynamics of two-phase biomembranes: Sharp interface variational formulation and finite element approximation
Creators: name: Barrett, John W.
name: Garcke, Harald
name: Nürnberg, Robert
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35R01, 49Q10, 65M12, 65M60, 82B26, 92C10

description: A finite element method for the evolution of a two-phase membrane in a sharp interface formulation is introduced. The evolution equations are given as an $L^2$--gradient flow of an energy involving an elastic bending energy and a line energy. In the two phases Helfrich-type evolution equations are prescribed, and on the interface, an evolving curve on an evolving surface, highly nonlinear boundary conditions have to hold. Here we consider both $C^0$-- and $C^1$--matching conditions for the surface at the interface. A new weak formulation is introduced, allowing for a stable semidiscrete parametric finite element approximation of the governing equations. In addition, we show existence and uniqueness for a fully discrete version of the scheme. Numerical simulations demonstrate that the approach can deal with a multitude of geometries. In particular, the paper shows the first computations based on a sharp interface description, which are not restricted to the axisymmetric case.
description: 46 pages, 22 figures
Impacts of Personal Characteristics on User Trust in Conversational Recommender Systems
Creators: name: Cai, Wanling
name: Jin, Yucheng
name: Chen, Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Conversational recommender systems (CRSs) imitate human advisors to assist users in finding items through conversations and have recently gained increasing attention in domains such as media and e-commerce. Like in human communication, building trust in human-agent communication is essential given its significant influence on user behavior. However, inspiring user trust in CRSs with a "one-size-fits-all" design is difficult, as individual users may have their own expectations for conversational interactions (e.g., who, user or system, takes the initiative), which are potentially related to their personal characteristics. In this study, we investigated the impacts of three personal characteristics, namely personality traits, trust propensity, and domain knowledge, on user trust in two types of text-based CRSs, i.e., user-initiative and mixed-initiative. Our between-subjects user study (N=148) revealed that users' trust propensity and domain knowledge positively influenced their trust in CRSs, and that users with high conscientiousness tended to trust the mixed-initiative system.
description: 14 pages, 5 figures, 6 tables, accepted for CHI 2022