Additional file 1 of Brain-derived neurotrophic factor gene variants and obesity in former smokers
Creators: name: Yang, Shan-shan
name: He, Yao
name: Xu, Lin
name: Jin, Yali
name: Zhang, Wei-sen
name: Jiang, Chao-qiang
name: Cheng, Kar Keung
name: Lam, Tai Hing
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 1 Table S1–1 The relationship between rs6265, rs11030104 and body mass index (BMI) in the total study sample (N = 15,072). Table S1–2 The relationship between rs4923457, rs6484320 and heavy smoking (cigarettes per day ≥ 20) in smokers (N = 2220). Table S1–3 The relationship between the four SNPs and waist circumference by sex in the total study sample (female = 11,903, male = 3169). Table S2 Interaction between different SNPs and smoke exposure group. Table S3 Linkage disequilibrium (LD) analysis of the four SNPs’ association with general obesity‡ in former smokers. Table S4 Linkage disequilibrium (LD) analysis of the four SNPs’ association with central obesity‡ in former smokers. Table S5 Association of different smoke exposure groups before cessation with general obesity and central obesity (grouped and continuous variables) in former smokers. Table S6 Association of SNPs with general obesity in different cigarettes per day (CPD) groups before cessation in former smokers. Table S6–1 Association of SNPs with general obesity in different cigarettes per day (CPD) groups before cessation in former smokers (additive model). Table S7 Association of SNPs with general obesity in different Heavy Smoking Index (HSI) score groups before cessation in former smokers. Table S7–1 Association of SNPs with general obesity in different Heavy Smoking Index (HSI) score groups before cessation in former smokers (additive model). Table S8 Association of SNPs with general obesity in different Fagerstrom Test for Nicotine Dependence (FTND) score groups before cessation in former smokers. Table S8–1 Association of SNPs with general obesity in different Fagerstrom Test for Nicotine Dependence (FTND) score groups before cessation in former smokers (additive model). Table S9 Association of SNPs with central obesity in different cigarettes per day (CPD) groups before cessation in former smokers. Table S9–1 Association of SNPs with central obesity in different cigarettes per day (CPD) groups before cessation in former smokers (additive model). Table S10 Association of SNPs with central obesity in different Heavy Smoking Index (HSI) score groups before cessation in former smokers. Table S10–1 Association of SNPs with central obesity in different Heavy Smoking Index (HSI) score groups before cessation in former smokers (additive model). Table S11 Association of SNPs with central obesity in different Fagerstrom Test for Nicotine Dependence (FTND) score groups before cessation in former smokers. Table S11–1 Association of SNPs with central obesity in different Fagerstrom Test for Nicotine Dependence (FTND) score groups before cessation in former smokers (additive model). Table S12 Odds ratios (ORs) (95%CI) of general obesity for different SNPs in different smoke exposure groups (excluding participants with body mass index (BMI) &lt; 18.5 (N = 14,329). Table S13 Odds ratios (ORs) (95%CI) of general obesity for different SNPs in former smokers (grouped by years of smoking cessation). Table S14 Relative risks (RRs) (95%CI) of new general obesity for different SNPs in former smokers. Table S15 Odds raios (ORs) (95%CI) of central obesity for different SNPs in former smokers (grouped by years of smoking cessation). Table S16 Relative risks (RRs) (95%CI) of new central obesity for different SNPs in former smokers. Table S17 Odds Ratios (ORs) (95%CI) of general obesity‡ for different SNPs in different smoke exposure groups (including participants whose weight changed significantly since 18 years old only, N = 11,891). Table S18 Odds ratios (ORs) (95%CI) of central obesity‡ for different SNPs in different smoke exposure groups (including participants whose waist circumference changed significantly since 18 years old only, N = 11,485). Table S19 Odds ratios (ORs) (95%CI) of central obesity‡ for different SNPs in different smoke exposure groups (including male participants whose waist circumference changed significantly since 18 years old only, N = 2299). Table S20 Odds ratios (ORs) (95%CI) of general obesity and central obesity‡ for different SNPs in former smokers (excluding participants who quit smoking because of diseases, N = 746). Table S21 Characteristics of the participants with or without genetic data. Table S22 Odds ratios (95%CI) of general obesity for different SNPs in different smoke exposure groups (additive model). Table S23 Odds ratios (95%CI) of central obesity for different SNPs in different smoke exposure groups (additive model). S24 The new 8 SNPs both related with smoking behavior and BMI in EBI GWAS Catalog.