Additional file 2 of Role of antenatal plasma cytomegalovirus DNA levels on pregnancy outcome and HIV-1 vertical transmission among mothers in the University of Zimbabwe birth cohort study (UZBCS)
Creators: name: Duri, Kerina
name: Simbarashe Chimhuya
name: Exnevia Gomo
name: Privilege Tendai Munjoma
name: Panashe Chandiwana
name: Yindom, Louis Marie
name: Kudakwashe Mhandire
name: Ziruma, Asaph
name: Sekesai Mtapuri-Zinyowera
name: Lovemore Ronald Mazengera
name: Misselwitz, Benjamin
name: Gumbo, Felicity Zvanyadza
name: Jordi, Sebastian
name: Rowland-Jones, Sarah
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2. Table 1: HIV-infected non-transmitting participants. Comparison of characteristics of HIV-infected non-transmitting participants between the study sample and the control sample. Data are expressed as n (%) or median (IQR); min-max unless stated otherwise. P-values to compare patient groups were calculated using the Mann-Whitney U test or Fisher’s exact test where appropriate. Missing data are indicated in the following manner: number of * = number of missing data points. Abbreviations: BMI: body mass index, CMV: cytomegalovirus, HIV: human immunodeficiency virus, WHO: world health organisation, N/A: not applicable. Table 2: HIV-uninfected participants. Comparison of characteristics of HIV-uninfected mothers between the study sample and the control sample. Data are expressed as n (%) or median (IQR); min-max unless stated otherwise. P-values to compare groups were calculated using Mann-Whitney U test or Fisher’s exact test where appropriate. Missing data are indicated in the following manner: number of * = number of missing data points. Abbreviations: BMI: body mass index, CMV: cytomegalovirus, HIV: human immunodeficiency virus, WHO: world health organisation, N/A: not applicable. Table 3: HIV-infected and uninfected study participants. Sample characteristics stratified for HIV status and CMV-DNAemia (4). Data are expressed as n (%) or median (IQR); min-max unless stated otherwise. P-values to compare patient groups were calculated using the Kruskal Wallis test, Mann-Whitney U test or Fisher’s exact test where appropriate. Missing data are indicated in the following manner: number of * = number of missing data points. Abbreviations: BMI: body mass index, CMV: cytomegalovirus, HIV: human immunodeficiency virus, WHO: world health organisation, N/A: not applicable. Table 4: CMV viremic and aviremic participants. Sample characteristics stratified for HIV status, cART exposure and CMV status and analysis of differences in participant groups. Data are expressed as n (%) or median (IQR); min-max unless stated otherwise. For calculation of vertical transmissions only infants that survived the first 6 weeks were included; exclusions due to death are marked with one “†” for each deceased infant. P-values to compare patient groups were calculated using the Kruskal Wallis test, Mann-Whitney U test or Fisher’s exact test where appropriate. Missing data are indicated in the following manner: number of * = number of missing data points. Abbreviations: BMI: body mass index, CMV: cytomegalovirus, cART: combination antiretroviral treatment, HIV: human immunodeficiency virus, WHO: world health organisation, N/A: not applicable. Table 5: Predictors of maternal CMV-DNA load. Linear regression showing the association of different variables with maternal CMV-DNA load in HIV-infected non-transmitting mothers after the removal of 0 outliers by the Tukey's fences method (Q1 – 3×IQR and Q3 + 3×IQR). Results are presented as linear coefficients; p-values are indicated as follows: *: p&lt;0.1, **: p&lt;0.05, ***: p&lt;0.01. 121 participants were analysed. Abbreviations: CI: 95% confidence interval, CMV: cytomegalovirus, cART: combination antiretroviral treatment, HIV: human immunodeficiency virus, IQR: interquartile range, Q: quartile. Table 6: Predictors for pre-term birth (&lt;37 weeks of pregnancy). Logistic regression showing the association of different variables with preterm birth in HIV-infected but non-transmitting mothers. Results are presented as odds ratios; p-values are indicated as follows: *: p&lt;0.1, **: p&lt;0.05, ***: p&lt;0.01. 169 participants were analysed. Abbreviations: CI: 95% confidence interval, CMV: cytomegalovirus. Table 7: Predictors for pre-term birth (&lt;37 weeks of pregnancy). Logistic regression showing the association of different variables with preterm birth in HIV-infected but non-transmitting mothers. Results are presented as odds ratios; p-values are indicated as follows: *: p&lt;0.1, **: p&lt;0.05, ***: p&lt;0.01. 36 participants were analysed. Abbreviations: CI: 95% confidence interval, CMV: cytomegalovirus, cART: combination antiretroviral treatment, HIV: human immunodeficiency virus.