cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk of respiratory, thoracic, and mediastinal disorders associated with endothelin receptor antagonists and prostacyclin-related drugs in pulmonary hypertension: a disproportionality analysis based on FAERS
Creators: name: Tang, Fengjie
name: Ma, Qihuan
name: Liu, Yinghong
name: Yang, Xiaojuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Adverse drug events (ADEs) for endothelin receptor antagonists (ERAs) and prostacyclin-related drugs (PRDs) have been reported in clinical trials, but large-scale, real-world evaluations for respiratory, thoracic, and mediastinal disorders (RTMD) remain scarce. A pharmacovigilance analysis of the FAERS database (Q1 2004~Q2 2024) used the reporting odds ratio (ROR) method for disproportionality analysis to assess the adverse drug events (ADEs) of ERAs and PRDs in pulmonary arterial hypertension, focusing on risks related to RTMD. Reports of ADEs for ERAs (bosentan, ambrisentan, and macitentan) were 15,286, 36795, and 17,497, respectively, and for PRDs (epoprostenol, treprostinil, iloprost, and selexipag) were 5,477, 57265, 3,247, and 5,504. Females exceeded males, with most cases in adults. The top PTs for ERAs were death, dyspnea, and pneumonia, with bosentan linked to liver impairment. PRDs commonly cause headaches, flushing, hypotension, edema, and fluid retention. Dyspnea was the most reported RTMD risk for all drugs, and nasal congestion was noted for all. Selexipag had the fewest RTMD-related PTs, and iloprost had the strongest signal for hemoptysis. The analysis highlights the RTMD risks of ERAs and PRDs in treating PH and underscores the need for careful monitoring of ADEs to ensure their safe and effective use in clinical practice.
title: Toward a More Complete Picture of Student Learning: Assessing Students’ Motivational Beliefs
Creators: name: Beghetto, Ronald A.
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: The purpose of this article is to provide an overview of the assessment of students’ motivational beliefs.  The body of the article is focused on a particular type of motivational belief, namely, beliefs involving achievement goal orientations.  I explain why these beliefs are an important aspect of academic learning, and suggest how teachers can incorporate assessments of them within existing classroom routines. Accessed 61,131 times on https://pareonline.net from August 08, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Analysis of unbounded operators and random motion
Creators: name: Jorgensen, Palle E. T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 47B25; 47B32; 47B37; 47S50; 60H25; 81S10; 81S25

description: We study infinite weighted graphs with view to \textquotedblleft limits at infinity,\textquotedblright or boundaries at infinity. Examples of such weighted graphs arise in infinite (in practice, that means \textquotedblleft very\textquotedblright large) networks of resistors, or in statistical mechanics models for classical or quantum systems. But more generally our analysis includes reproducing kernel Hilbert spaces and associated operators on them. If $X$ is some infinite set of vertices or nodes, in applications the essential ingredient going into the definition is a reproducing kernel Hilbert space; it measures the differences of functions on $X$ evaluated on pairs of points in $X$. And the Hilbert norm-squared in $\mathcal{H}(X)$ will represent a suitable measure of energy. Associated unbounded operators will define a notion or dissipation, it can be a graph Laplacian, or a more abstract unbounded Hermitian operator defined from the reproducing kernel Hilbert space under study. We prove that there are two closed subspaces in reproducing kernel Hilbert space $\mathcal{H}(X)$ which measure quantitative notions of limits at infinity in $X$, one generalizes finite-energy harmonic functions in $\mathcal{H}(X)$, and the other a deficiency index of a natural operator in $\mathcal{H}(X)$ associated directly with the diffusion. We establish these results in the abstract, and we offer examples and applications. Our results are related to, but different from, potential theoretic notions of \textquotedblleft boundaries\textquotedblright in more standard random walk models. Comparisons are made.
description: 38 pages, 4 tables, 3 figures
title: Thinking About How to Evaluate Your Program? These Strategies Will Get You Started
Creators: name: Gajda, Rebecca
name: Jewiss, Jennifer
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: Accessed 327,227 times on https://pareonline.net from March 25, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: IRT-Linked Standard Errors of Weighted Composites
Creators: name: Childs, Ruth A.
name: Elgie, Susan
name: Gadalla, Tahany
name: Traub, Ross
name: Jaciw, Andrew P.
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: In this study, we describe an approach to calculating the standard errors of weighted scores while maintaining a link to the IRT score metric, then use the approach to compare three sets of weights. Weighting a mathematics test’s multiple-choice items, short-answer items, and extended constructedresponse items to achieve a ratio of 2:2:6 on the raw score metric had little effect on examinee scores or standard errors. Ratios of 3:3:4 and of 1:1:8 required more extreme weights and had a slightly larger, but still small, effect on results, increasing the standard errors. Overall, as the difference between the intended emphasis and the test’s design increased, the effect of the weighting also increased. Accessed 23,240 times on https://pareonline.net from June 25, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Generalized Green-Kubo formula for a dissipative quantum system
Creators: name: Hayakawa, Hisao
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A generalized Green-Kubo formula is derived for a quantum dissipative system of driven Brownian particle, in which the coupling between the system and the environment is linear. The structure is essentially the same as that for the generalized Green-Kubo formula for driven granular particles. It is demonstrated that the correction to the conventional Green-Kubo formula is zero for a free Brownian particle.
description: 12 pages, no figures. Prog. Theor. Phys. Suppl. (to be published)
title: Effects of Handwriting and Computer-Print on Composition Scores: A Follow-up to Powers, Fowles, Farnum, & Ramsey
Creators: name: Michael, Russell
name: Tao, Wei
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: Powers, Fowles, Farnum, & Ramsey (1994) report that essays presented in handwritten form receive..higher scores than the same essays presented as computer-text. The study presented here partially..replicates the study conducted by Powers et al. In addition, this study explores the extent to which..several types of errors in student writing are more visible when essays are presented as computertext...The two experiments presented here partially confirm previous findings that essays presented in..computer print receive lower scores and that part of this effect may result from the increased visibility..of errors in computer-text. Through interviews with readers, this study also suggests that the higher..standards and expectations readers have for text presented as computer print and the ability of some..readers to identify with students and see their effort when they handwrite essays may impact the..scores they award. Unlike Powers et al, however, this study does not find evidence that altering the..spacing of essays presented in computer print in order to increase the perceived length consistently..reduces the presentation effect. Accessed 34,106 times on https://pareonline.net from January 20, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Genetic Algorithm Based Optimization of Clustering in Ad Hoc Networks
Creators: name: Nandi, Bhaskar
name: Barman, Subhabrata
name: Paul, Soumen
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In this paper, we have to concentrate on implementation of Weighted Clustering Algorithm with the help of Genetic Algorithm (GA).Here we have developed new algorithm for the implementation of GA-based approach with the help of Weighted Clustering Algorithm (WCA) (4). ClusterHead chosen is a important thing for clustering in adhoc networks. So, we have shown the optimization technique for the minimization of ClusterHeads(CH) based on some parameter such as degree difference, Battery power (Pv), degree of mobility, and sum of the distances of a node in adhoc networks. ClusterHeads selection of adhoc networks is an important thing for clustering. Here, we have discussed the performance comparison between deterministic approach and GA based approach. In this performance comparison, we have seen that GA does not always give the good result compare to deterministic WCA algorithm. Here we have seen connectivity (connectivity can be measured by the probability that a node is reachable to any other node.) is better than the deterministic WCA algorithm (4).
description: IEEE format, International Journal of Computer Science and Information Security, IJCSIS January 2010, ISSN 1947 5500, http://sites.google.com/site/ijcsis/
Quantitative studies of hydrogen bonding in ortho-substituted phenols using proton magnetic resonance.
Creators: name: Allan, Ernest Albert
Publisher: name: University of British Columbia
Year: 2011

description: The chemical shift of protons in intramolecular hydrogen bonds has been measured in 41 ortho substituted phenol type compounds. The change in chemical shift " ΔσOH " on formation of these hydrogen bonds is taken as the difference between the infinite dilution chemical shift of the parent phenol compound in CCl₄ solution and the chemical shift measured for the proton in the intramolecular hydrogen bond. This change in chemical shift is correlated with the corresponding frequency shift " ΔνOH " in the -OH stretching region of the infra-red spectrum. The dilution chemical shift for the -OH proton in the o-halophenols has been investigated over a concentration range 1-5 mole % in CS₂ and a temperature region -53 to 107°C Using the infinite dilution shift values, the equilibrium constants of the cis-trans conversion were obtained. Values for δCIS, the chemical shift of the completely hydrogen bonded form; δ TRANS, the chemical shift of the unbonded form, and ΔH , the enthalpy of formation of the hydrogen bond, were also calculated. From these results a value for ΔH, the enthalpy of formation for the dimer was calculated, assuming that the major dimer species in solution was formed from the combination of a cis and trans bonded form. Temperature studies of the change in chemical shift of the -OH proton for 2,1,6-trihalosubstituted phenols is also reported. The temperature range in this case was 0°C to 111°0.
title: Designing Accountability Assessments for Teaching
Creators: name: Schafer, William D.
name: Moody, Mark
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: We argue (1) that the domains of externally mandated tests should be transparent to teachers, (2) that test maps can be used to communicate with teachers, and (3) that the most effective test maps express domains in terms of combinations of what students know and can do.  We propose a device called a heuristic as the lowest level of specificity in a test map, and criteria to achieve a balance between too much specificity and too much generality in heuristics.  Although we focus primarily on summative assessments, we also discuss how a state may use related, teacher-developed formative assessments to foster information-rich classroom environments. Other than item bank structure and sampling, our suggestions would have little impact on how tests are developed or scored, but we believe they would have a large impact on how they are described and used, and ultimately on their effectiveness as agents of instructional reform. Accessed 37,284 times on https://pareonline.net from July 25, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Physics with KLOE at DAPHNE
Creators: name: P. Franzini
name: KLOE Collaboration
Publisher: name: INFN Open Access Repository
Year: 1995

description: Experimental measurements which can be done at DAPHNE, the ∅-factory under construction at the Laboratori Nazionali di Frascati dell'INFN, are presented. We also describe the KLOE detector, optimized for performing these measurements.
Abundances in bulge stars from high-resolution, near-IR spectra I. The CNO elements observed during the science verification of CRIRES at VLT
Creators: name: Ryde, Nils
name: Edvardsson, Bengt
name: Gustafsson, Bengt
name: Eriksson, Kjell
name: Kaufl, Hans Ulrich
name: Siebenmorgen, Ralf
name: Smette, Alain
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The formation and evolution of the Milky Way bulge is not yet well understood and its classification is ambiguous. Constraints can, however, be obtained by studying the abundances of key elements in bulge stars. The aim of this study is to determine the chemical evolution of CNO, and a few other elements in stars in the Galactic bulge, and to discuss the sensitivities of the derived abundances from molecular lines. High-resolution, near-IR spectra in the H band were recorded using VLT/CRIRES. Due to the high and variable visual extinction in the line-of-sight towards the bulge, an analysis in the near-IR is preferred. The CNO abundances can all be determined simultaneously from the numerous molecular lines in the wavelength range observed. The three giant stars in Baade's window presented here are the first bulge stars observed with CRIRES. We have especially determined the CNO abundances, with uncertainties of less than 0.20 dex, from CO, CN, and OH lines. Since the systematic uncertainties in the derived CNO abundances due to uncertainties in the stellar fundamental parameters, notably Teff, are significant, a detailed discussion of the sensitivities of the derived abundances is included. We find good agreement between near-IR and optically determined O, Ti, Fe, and Si abundances. Two of our stars show a solar [C+N/Fe], suggesting that these giants have experienced the first dredge-up and that the oxygen abundance should reflect the original abundance of the giants. The two giants fit into the picture, in which there is no significant difference between the O abundance in bulge and thick-disk stars. Our determination of the S abundances is the first for bulge stars. The high [S/Fe] values for all the stars indicate a high star-formation rate in an early phase of the bulge evolution.
description: Accepted by A&A
Mini-Jet Total Cross-Sections and Overlap Functions through Bloch-Nordsieck Summation
Creators: name: A. Corsetti
name: R. M. Godbole
name: A. Grau
name: G. Pancheri
name: Y.N. Srivastava
Publisher: name: INFN Open Access Repository
Year: 1996

description: Predictions for total inelastic cross-sections for photon induced processes are discussed in the context of the QCD-inspired minijet model. Large theoretical uncertainties exist, some of them related to the parton distributions of hadrons in impact parameter space. A model for such distribution is presented, based on soft gluon summation. This model incorporates (the salient features of distributions obtained from) the intrinsic transverse momentum behaviour of hadrons. Under the assumption that the intrinsic behaviour is dominated by soft gluon emission stimulated by the scatering process, the b-spectrum becomes softer and softer as the scattering energy increases. In minijet models for the inclusive cross-sections, this will counter the increase from sjet.
Particle fluctuations in nonuniform and trapped Bose gases
Creators: name: Yukalov, V. I.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The problem of particle fluctuations in arbitrary nonuniform systems with Bose-Einstein condensate is considered. This includes the case of trapped Bose atoms. It is shown that the correct description of particle fluctuations for any nonuniform system of interacting atoms always results in thermodynamically normal fluctuations.
description: Latex file, 16 pages
title: The Contributions of Reliability and Pretests to Effective Assessment
Creators: name: Bacon, Donald
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: This paper shows how the reliability of measures and the use of pretests (or covariates) both have the..potential to increase the statistical power in research designs. Tables are presented that show how specific..changes in these factors can dramatically reduce the sample size necessary to determine whether an..intervention is effective, thus potentially improving the effectiveness of assessment in terms of reducing the..time and cost of collecting scientific support for new practices. Accessed 36,222 times on https://pareonline.net from February 26, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Classroom Assessment in Web-Based Instructional Environment: Instructors’ Experience
Creators: name: Liang, Xin
name: Creasy, Kim
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: While a great deal has been written on the advantage and benefits of online teaching, little is known on how assessment is implemented in online classrooms to monitor and inform performance and progress.  The purpose of this study is to investigate the dynamics of WebCT classroom assessment by analyzing the perceptions and experience of the instructors.  Grounded theory method was employed to generate a “process theory”.  The study included 10 faculties who taught WebCT classes, and 216 students in the College of Education in an urban university in the Mid west.  Interviews and classroom observations were undertaken on line.  The findings indicated that, performance-based assessment, writing skills, interactive assessment and learner autonomy were major assessment aspects to inform teaching and enhance learning.  If one of the major roles of online instruction is to increase self-directed learning, as part of the pedagogical mechanism, web-based classroom assessment should be designed and practiced to impact learner autonomy. Accessed 80,418 times on https://pareonline.net from March 02, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Causality violating geodesics in Bonnor's rotating dust metric
Creators: name: Collas, Peter
name: Klein, David
Publisher: name: arXiv
Year: 2008
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We exhibit timelike geodesic paths for a metric, introduced by Bonnor [11] and considered also by Steadman [13], and show that coordinate time runs backward along a portion of these geodesics.
title: Estimating the Standard Error of the Judging in a modified-Angoff Standards Setting Procedure
Creators: name: MacCann, Robert G.
name: Gordon, Stanley
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: For a modified Angoff standards setting procedure, two methods of calculating the standard error of the judging were compared.  The Central Limit Theorem (CLT) method is easy to calculate and uses readily available data.  It estimates the variance of mean cut scores as a function of the variance of cut scores within a judging group, based on the independent judgements at Stage 1 of the process.  Its theoretical drawback is that it is unable to take account of the effects of collaboration among the judges at Stages 2 and 3.  The second method, an application of equipercentile (EQP) equating, relies on the selection of very large stable candidatures and the standardisation of the raw score distributions to remove effects associated with test difficulty.  The standard error estimates were then empirically obtained from the mean cut score variation observed over a five year period.  For practical purposes, the two methods gave reasonable agreement, with the CLT method working well for the top band, the band that attracts most public attention.  For some bands in English and Mathematics, the CLT standard error was smaller than the EQP estimate, suggesting the CLT method be used with caution as an approximate guide only. Accessed 31,793 times on https://pareonline.net from March 01, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Electronic Strucure and Final???State Effects in Nd2CuO4, La2CuO4, and Ca2CuO3 Compounds by Multiple???Scattering Theory at the Copper K Edge
Creators: name: Ziyu Wu
name: M. Benfatto
name: C.R. Natoli
Publisher: name: INFN Open Access Repository
Year: 1997

description: We present a theoretical analysis, based on the zeroth-order approximation of the multichannel multiple-scattering theory, of the x-ray-absorption spectra of Nd2CuO4, La2CuO4, and Ca2CuO3 compounds at the copper K edge. Single channel theoretical calculations have been made using atomic clusters large enough to be sure that all one-electron features have been correctly described. On this basis the presence of both 3d9 and 3d10L_  configurations in the ground state has been found essential to obtain good agreement between experimental data and theoretical calculations in the case of Nd2CuO4 and Ca2CuO3. Conversely, the best agreement with the La2CuO4 data has been obtained by taking into account only the 3d10L_  configuration in the final state. We briefly comment on this finding.
title: The Influence of Computer-Print on Rater Scores
Creators: name: Russell, Michael
name: Tao, Wei
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: This study replicates and extends the work of Powers, Fowles, Farnum, & Ramsey (1994) and Russell & Tao (2004) by examining the influence computer-print and handwriting have on raters’ scores.  This replication study employs an experimental design that presents the same set of responses to raters in four different formats.  A second experiment is conducted to explore the extent to which the presentation effect can be reduced by supplemental training that focuses specifically on the causes of this presentation effect and includes practice scoring of responses presented in different formats.  As Powers et al. and Russell and Tao found, the first experiment indicates that responses to composition test items presented in handwritten form receive significantly higher scores than the same responses presented in computer-print form.  This effect is due to the visibility of errors and higher expectations for computer-printed responses coupled with increased identity with the writer generated by handwriting.  Through supplemental training, the presentation effect was eliminated. Accessed 24,952 times on https://pareonline.net from May 11, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Course Selection Decisions by Students on Campuses With and Without Published Teaching Evaluations
Creators: name: Wilhelm, Wendy Bryce
name: Comegys, Charles
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: In spite of students’ increasingly vocal demands for access to official student evaluations of teaching (SET), little is known about the relative importance of SET in course selection decisions, and whether such evaluations are viewed by students as a valuable source of information about an instructor or course. Using conjoint analysis and a web survey to assess SET importance, we found that business students on campuses with published SET rated course evaluations as less important in course choice than students on campuses without published evaluations. Moreover, student perceptions of the amount of useful knowledge gained in the course and how lenient the instructor is in his/her grading practices were found to have the greatest influence on course choice within the business major.Accessed 47,403 times on https://pareonline.net from August 24, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Preliminary Results with ???Cincinnati Group Cell??? on Thorium ???Transumation???   Under 50Hz AC Excitation
Creators: name: F. Celani
name: M. Achilli
name: A. Battaglia
name: C. Cattaneo
name: C. Buzzanca
name: P.G. Sona
name: A. Mancini
Publisher: name: INFN Open Access Repository
Year: 1998

description: We give the procedure and the results of experiments performed with a standard "Cincinati Group Cell", aimed to observe possible "transmutation" of Th in other elements via an AC electrolytic process. Three techniques have been used to avoid bias due to spurious effects: a-radiometry, ICP/MS and ICP/optical, looking at difference between initial and final solution and between blank (no Th) and black (with Th) processed solutions. We found deficit of Th after process and new elements produced. The results are still not conclusive on transmutation and we discuss arguments in favour and against the transmutation hypothesis. We clarify the critical points of the measurements techniques, adding some suggestions to improve the reliability of results in future measurements.
Role of gliflozins on hepatocellular carcinoma progression: a systematic synthesis of preclinical and clinical evidence
Creators: name: Basile, Livia
name: Cannarella, Rossella
name: Magni, Paolo
name: Condorelli, Rosita A.
name: Calogero, Aldo E.
name: La Vignera, Sandro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The risk of HCC is twice as high in diabetic patients compared to non-diabetic ones, suggesting that diabetes advances carcinogenesis in the liver through a variety of mechanisms. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to improve liver outcomes, emerging as promising agents to treat hepatocellular carcinoma (HCC) in patients with type 2 diabetes mellitus (T2DM). We searched PubMed and Scopus databases for articles presenting an association between SGLT2is and HCC to explore the putative mechanisms of action underlying the anti-proliferative activity of SGLT2is. A total of 24 articles were selected for inclusion, of which 14 were preclinical and 10 were clinical. Preclinical studies were mainly focused on canagliflozin, used alone or in combination with other drugs. Overall, canagliflozin had a negative effect on HCC cell proliferation by interfering with glucose-dependent and independent metabolic pathways, negatively impacting angiogenesis, and inducing apoptosis in in-vitro cell models. In-vivo, a protective effect on hepatic steatosis and fibrosis and HCC development has been reported. Human studies showed a lower risk of developing HCC in patients on SGLT2is. However, this is supported by retrospective cohort studies. Clinical trials are needed to confirm the causal relationship between SGLT2i administration and HCC development.
Multi Product Inventory Optimization using Uniform Crossover Genetic Algorithm
Creators: name: Narmadha, S.
name: Selladurai, Dr. V.
name: Sathish, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Inventory management is considered to be an important field in Supply Chain Management because the cost of inventories in a supply chain accounts for about 30 percent of the value of the product. The service provided to the customer eventually gets enhanced once the efficient and effective management of inventory is carried out all through the supply chain. The precise estimation of optimal inventory is essential since shortage of inventory yields to lost sales, while excess of inventory may result in pointless storage costs. Thus the determination of the inventory to be held at various levels in a supply chain becomes inevitable so as to ensure minimal cost for the supply chain. The minimization of the total supply chain cost can only be achieved when optimization of the base stock level is carried out at each member of the supply chain. This paper deals with the problem of determination of base stock levels in a ten member serial supply chain with multiple products produced by factories using Uniform Crossover Genetic Algorithms. The complexity of the problem increases when more distribution centers and agents and multiple products were involved. These considerations leading to very complex inventory management process has been resolved in this work.
description: IEEE format, International Journal of Computer Science and Information Security, IJCSIS January 2010, ISSN 1947 5500, http://sites.google.com/site/ijcsis/
Enhancement of superconductivity near the ferromagnetic quantum critical point in UCoGe
Creators: name: Slooten, E.
name: Naka, T.
name: Gasparini, A.
name: Huang, Y. K.
name: de Visser, A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report a high-pressure single crystal study of the superconducting ferromagnet UCoGe. Ac-susceptibility and resistivity measurements under pressures up to 2.2 GPa show ferromagnetism is smoothly depressed and vanishes at a critical pressure $p_c = 1.4$ GPa. Near the ferromagnetic critical point superconductivity is enhanced. Upper-critical field measurements under pressure show $B_{c2}(0)$ attains remarkably large values, which provides solid evidence for spin-triplet superconductivity over the whole pressure range. The obtained $p-T$ phase diagram reveals superconductivity is closely connected to a ferromagnetic quantum critical point hidden under the superconducting `dome'.
description: 4 pages, 3 figures; accepted for publication in PRL
title: Sample size and subject to item ratio in principal components analysis
Creators: name: Osborne, Jason W.
name: Costello, Anna B.
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: Statisticians have wrestled with the question of sample size in exploratory factor analysis and principal component analysis for decades, some looking at total N, some at the ratio of subjects to items.  Although many articles attempt to examine this issue, few examine both possibilities comprehensively enough to be definitive.  This study examines a previously published data set to examine whether N or subject to item ratio is more important in predicting important outcomes in PCA.  The results indicate an interaction between the two, where the best outcomes occur in analyses where large Ns and high ratios are present. Accessed 116,372 times on https://pareonline.net from June 07, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Direct carbonylation of aromatic semi-carbazones and azines
Creators: name: Millward, Stewart
Publisher: name: University of British Columbia
Year: 2011

description: Benzophenone semicarbazone reacted with carbon monoxide at about 300 atmospheres and at 235-245° in the presence of preformed dicobalt octacarbonyl as catalyst to yield 3-phenylphthalimidine (XXXVII), 3-phenyl-2-(N-benzhydrylcarboxamido)phthalimidine (XXXIV), N,N’-dibenzhydrylurea (XXXV), and N-benzhydrylurea (XXXVI). At 200-220° benzophenone semicarbazone gave N-benzhydrylurea (XXXVI), benzophenone azine (XXXVIIl), and benzophenone 4benzhydrylsemicarbazone (XXXJX). When the reaction temperature was further reduced to 175-180°, benzophenone semicarbazone did not produce the carbonylation product obtained in the second experiment but only the degradation and reduction products, XXXVIIl and XXXIX respectively. Carbonylation of benzophenone azine (XXXVIIl) at 235-245° produced 3-phenylphthalimidine (XXXVIl), whereas carbonylation of benzophenone 4-benzhydrylsemicarbazone at the same temperature yielded 3-phenylphthalimidine and 3-phenyl-2-(N-benzhydryl-carboxaraido)phthalimidine (XXXIV). An independent synthesis of the latter compound and of benzophenone 4-benzhydrylsemicarbazone, both in good yield, has been carried out. When benzaldehyde semicarbazone was carbonylated at 200-220° only the degradation product, benzaldehyde azine (XLIl) was formed. Increasing the temperature to 235-245° did not alter the course of the reaction. Carbonylation of benzaldehyde azine at 235-245° yielded 2-benzylphthalimidine (XLVIIl), phthalimidine (L), and 2-(N-benzyl-carboxamido)phthalimidine (XLVI). The significance of the presence of phthalimidine and 2-(N-benzylcarboxaraido)phthalimidine in the carbonylation products of benzaldehyde azine is discussed in regard to the mechanism of the cyclization reaction. A mechanism is proposed for the cyclization reaction and evidence is presented in support of the proposal. The ureido group (-NHCONH₂) or its degradation products has been shown to have an inhibitory effect on the catalytic activity of dicobalt octacarbonyl. An independent synthesis of 2-(N-benzyIcarboxamido)phthalimidine is also reported.
Accretion History of Subhalo Population now and then
Creators: name: Giocoli, Carlo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In the standard model of structure formation galaxies reside in virialized dark matter haloes which extend much beyond the observational radius of the central system. The dark matter halo formation process is hierarchical, small systems collapse at high redshift and then merge together forming larger ones. In this work we study the mass assembly history of host haloes at different observation redshifts and the mass function of accreted satellites (haloes that merge directly on the main halo progenitor). We show that the satellite mass function is universal, both independent on the host halo mass and observation redshift. The satellite mass function also turn out to be universal once only satellites before or after the host halo formation redshift (time at which the main halo progenitor assembles half of its final mass) are considered. We show that the normalizations of these distributions are directly related to the main halo progenitor mass distributions before and after its formation, while their slope and the exponential high mass cut-off remain unchanged.
description: To appear in the proceedings of the "Invisible Universe International Conference 2009" (6 pages, 3 figures)
Mining and analysis of adverse events associated with aducanumab: a real-world study using FDA adverse event reporting system database
Creators: name: Wu, Shuangshuang
name: Qi, Yiming
name: Jiang, Cheng
name: Zheng, Junxian
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Aducanumab, a monoclonal antibody, received approval for the treatment of Alzheimer’s disease in 2021. However, it remains controversial over the security of this drug. In this study, aducanumab-related adverse events (AEs) were evaluated through data mining based on the FDA Adverse Event Reporting System (FAERS) database. The AE reports induced by aducanumab as the primary suspected drug were extracted from the FAERS database. The clinical characteristics of aducanumab-associated reports were analyzed. The potential new AE signals of aducanumab were explored using four disproportionality analysis methods. Furthermore, the difference in aducanumab-associated AE signals was investigated concerning sex, age, weight, dose, onset time, and continent. In total, 328 reports and 793 AEs associated with aducanumab were identified. Six new AEs were identified. No significant sex and weight difference in aducanumab-related signals was found. Notably, nervous system disorders, especially ‘amyloid related imaging abnormality-oedema/effusion’ and ‘amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits,’ were more likely to be reported within 121-240 days, particularly in Europe. This study contributes real-world evidence regarding the safety of aducanumab.
title: Recommending cut scores with a subset of items: An empirical illustration
Creators: name: Buckendahl, Chad W.
name: Ferdous, Abdullah A.
name: Gerrow, Jack
Publisher: name: University of Massachusetts Amherst
Year: 2010

description: Many testing programs face the practical challenge of having limited resources to conduct comprehensive standard setting studies. Some researchers have suggested that replicating a groupâ€™s recommended cut score on a full-length test may be possible by using a subset of the items. However, these studies were based on simulated data. This study describes a standard setting application using two independent panels providing judgments on a 300-item licensure test. Specifically, one panel provided judgments on all 300 items; whereas the second panel made judgments on a randomly-selected subset of 150 items. Both panels also participated in an alternate standard setting method to evaluate panel comparability. Results suggest caution for practitioners considering using subsets of items for standard setting studies. Accessed 7,224 times on https://pareonline.net from May 11, 2010 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
D.A.F.N.E. DESIGN CRITERIA AND PROJECT OVERVIEW
Creators: name: P. AMADEI
name: A. ARAGONA
name: S. BARTALUCCI
name: M. BASSETTI
name: M. E. BIAGINI
name: C. BISCARI
name: R. BONI
name: A. CATTONI
name: V. CHIMENTI
name: A. CLOZZA
name: S. DE SIMONE
name: G. DI PIRRO
name: S. FAINI
name: R. FEDELE
name: A. GALLO
name: A. GHIGO
name: S. GUIDUCCI
name: H. HSIEH
name: S. KULINSKI
name: M. R. MASULLO
name: C. MILARDI
name: M. MODENA
name: L. PALUMBO
name: M. PREGER
name: G. RAFFONE
name: C. SANELLI
name: M. SERIO
name: F. SGAMMA
name: B. SPATARO
name: A. STECCHI
name: L. TRASATTI
name: C. VACCAREZZA
name: V. G. VACCARO
name: M. VESCOVI
name: S. VESCOVI
name: G. VIGNOLA
name: J. WANG
name: M. ZOBOV
Publisher: name: INFN Open Access Repository
Year: 1991

description: The basic design criteria of DAPHNE, the Frascati \\Phi-factory, are discussed and a project overview is presented.
title: Prevalence and characteristics of student attitude surveys used in public elementary schools in the United States
Creators: name: Stapleton, Laura M.
name: Cafarelli, Michael
name: Almario, Miguel N.
name: Ching, Tom
Publisher: name: University of Massachusetts Amherst
Year: 2010

description: There is anecdotal evidence of an increase in school administrator's use of surveys of students to obtain school climate information even though it is difficult to obtain valid measurement from student self-report. To better understand the context, this research estimated the prevalence of the use of student surveys in elementary schools and reviewed the types of questions and response options currently used in applied settings. A survey was administered to a nationally representative sample of 300 public elementary school principals (34% response rate). Approximately half of the schools use surveys of students in their schools, with rates of surveying depending on the grade. A qualitative review of example surveys suggests that many typically-used questions may be problematic, given research on best methods of attitude measurement. Suggestions for practice and future research directions are provided. Accessed 11,640 times on https://pareonline.net from May 18, 2010 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Efficient Inventory Optimization of Multi Product, Multiple Suppliers with Lead Time using PSO
Creators: name: Narmadha, S.
name: Selladurai, Dr. V.
name: Sathish, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: With information revolution, increased globalization and competition, supply chain has become longer and more complicated than ever before. These developments bring supply chain management to the forefront of the managements attention. Inventories are very important in a supply chain. The total investment in inventories is enormous, and the management of inventory is crucial to avoid shortages or delivery delays for the customers and serious drain on a companys financial resources. The supply chain cost increases because of the influence of lead times for supplying the stocks as well as the raw materials. Practically, the lead times will not be same through out all the periods. Maintaining abundant stocks in order to avoid the impact of high lead time increases the holding cost. Similarly, maintaining fewer stocks because of ballpark lead time may lead to shortage of stocks. This also happens in the case of lead time involved in supplying raw materials. A better optimization methodology that utilizes the Particle Swarm Optimization algorithm, one of the best optimization algorithms, is proposed to overcome the impasse in maintaining the optimal stock levels in each member of the supply chain. Taking into account the stock levels thus obtained from the proposed methodology, an appropriate stock levels to be maintained in the approaching periods that will minimize the supply chain inventory cost can be arrived at.
description: IEEE format, International Journal of Computer Science and Information Security, IJCSIS January 2010, ISSN 1947 5500, http://sites.google.com/site/ijcsis/
Safety profile of isocitrate dehydrogenase inhibitors in cancer therapy: a pharmacovigilance study of the FDA adverse event reporting system
Creators: name: Fu, Yiming
name: Lv, Ruxue
name: Li, Ruizhen
name: Li, Wenjie
name: Guo, Zhaoze
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Isocitrate dehydrogenase (IDH) inhibitors hold promise for IDH-mutated cancer patients and demonstrated favorable clinical efficacy. Nonetheless, a comprehensive understanding of the associated toxicities of IDH inhibitors remains notably lacking. This pharmacovigilance analysis utilized the FDA Adverse Event Reporting System (FAERS) database to assess notable adverse events (AEs) attributed to IDH inhibitors (enasidenib and ivosidenib) from January 2018 to December 2023. In the FAERS database, 2,905 enasidenib-associated and 1,289 ivosidenib-related AEs records were identified, respectively. The toxicity profiles of IDH1 and IDH2 inhibitors exhibited notable similarities. The most commonly significant system-organ classes induced by IDH inhibitors encompassed general disorders and administration site conditions, investigations, gastrointestinal disorders, and infections and infestations. The most common AEs included nausea, fatigue, diarrhea, decreased appetite, decreased platelet count, fever, pneumonia, weakness, sepsis, constipation, vomiting, rash, and reduced hemoglobin levels. Notably, temporal analysis of AEs shows enasidenib and ivosidenib have median onset times of 137 and 75 days, with distinct initial peak frequencies. The reversible nature of the toxicities associated with IDH inhibitors underscores their promise as a therapeutic agent with a favorable safety profile.
title: Improving your data transformations: Applying the Box-Cox transformation
Creators: name: Osborne, Jason
Publisher: name: University of Massachusetts Amherst
Year: 2010

description: Many of us in the social sciences deal with data that do not conform to assumptions of normality and/or homoscedasticity/homogeneity of variance. Some research has shown that parametric tests (e.g., multiple regression, ANOVA) can be robust to modest violations of these assumptions. Yet the reality is that almost all analyses (even nonparametric tests) benefit from improved the normality of variables, particularly where substantial non-normality is present. While many are familiar with select traditional transformations (e.g., square root, log, inverse) for improving normality, the Box-Cox transformation (Box & Cox, 1964) represents a family of power transformations that incorporates and extends the traditional options to help researchers easily find the optimal normalizing transformation for each variable. As such, Box-Cox represents a potential best practice where normalizing data or equalizing variance is desired. This paper briefly presents an overview of traditional normalizing transformations and how Box-Cox incorporates, extends, and improves on these traditional approaches to normalizing data. Examples of applications are presented, and details of how to automate and use this technique in SPSS and SAS are included. Accessed 57,471 times on https://pareonline.net from October 06, 2010 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Quantum Ratchets with Few Bands below the Barrier
Creators: name: Grifoni, Milena
name: Ferreira, M. S.
name: Peguiron, J.
name: Majer, J. B.
Publisher: name: Universität Regensburg
Year: 2002
Subjects: subject: 530 Physik

description: We investigate directed motion in nonadiabatically rocked ratchet systems sustaining few bands below the barrier. Upon restricting the dynamics to the lowest M bands, the total system-plus-bath Hamiltonian is mapped onto a discrete tight-binding model containing all the information both on the intrawell and interwell tunneling motion. A closed form for the current in the incoherent tunneling regime is obtained. In effective single-band ratchets, no current rectification occurs. We apply our theory to describe rectification effects in vortex quantum ratchets devices. Current reversals upon variation of the ac-field amplitude or frequency are predicted.