cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Therapeutic Hyperthermia for Reservoir Disruption: A Novel Approach to Enhance Human Healthspan
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025
Subjects: Therapeutic Hyperthermia
Pathogen Reservoirs
Biofilms
Chronic Infections
Latent Infections
Immune System
Healthspan
Aging
Non-invasive Therapies
Targeted Heat Delivery

description: Abstract

Chronic and latent infections, characterized by the persistence of pathogens in hidden reservoirs within the human body, represent a profound and often overlooked challenge to long-term health and healthspan. Conventional antimicrobial therapies often fail to eradicate these reservoirs, leading to recurrent infections, chronic inflammation, and accelerated age-related decline. This paper proposes a paradigm shift in infection management: Therapeutic Hyperthermia for Reservoir Disruption. We hypothesize that precisely controlled, localized heat application can disrupt pathogen reservoirs, weaken biofilm protection, directly inactivate pathogens, and stimulate localized immune responses, thereby facilitating pathogen clearance and enhancing human healthspan. We explore the mechanistic underpinnings of this novel therapeutic approach, outline advanced technologies for targeted and safe heat delivery, review preclinical evidence supporting its efficacy, and discuss the transformative potential of therapeutic hyperthermia to address the unmet needs of reservoir-associated infections and promote a new era of proactive healthspan extension in the 21st Century.
Biomechanical analysis of patient-specific knee pathologies and treatments: a musculoskeletal modelling investigation
Creators: name: Farshidfar, Sara sadat
Publisher: name: Macquarie University
Year: 2023
Subjects: classificationCode: 400303
subject: Biomechanical engineering

description: In knee trauma, such as anterior cruciate ligament (ACL) rupture, the mechanical environment of the joint is altered. Patients with ACL-deficient knees can experience increased incidence of knee osteoarthritis (OA), leading to the need for total knee arthroplasty (TKA). Understanding knee joint mechanics is imperative to improving surgery and patient outcomes. This thesis aimed to use musculoskeletal modelling to assess knee pathologies and treatments by developing a validated patient-specific musculoskeletal knee model to predict joint biomechanics in ACL-deficient and reconstructed knees; and examining changes in kinetics and kinematics of OA patients during dynamic activities before and after TKA.
Application of Code of Ethics to Non-U.S. Engineers (adapted from NSPE Case No. 98-2)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Bribery and Extortion
Cultural Awareness and Sensitivity
Ethics and Society
Research and Practice
Workplace Ethics

description: An engineer and member of international NSPE wonders whether he should engage in a practice which is legally acceptable in his country but against the code of ethics of NSPE.
Serving Plaintiffs and Defendants (adapted from NSPE Case No. 98-4)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Engineer/Client Relationships
Ethics and Society
Expert Witness
Research and Practice
Social Responsibility
Workplace Ethics

description: An expert in her field, an engineer is approached by lawyers for manufacturer XYZ to testify on behalf of XYZ. Later, a plaintiff asks her to testify in an unrelated lawsuit against manufacturer XYZ. Does accepting the second job create a conflict of interest for her?
РОССИЙСКО-КИТАЙСКИЕ ОТНОШЕНИЯ: МЕЖДУ ЕВРОПОЙ И ИНДО-ПАСИФИКОЙ (ЧАСТЬ II)
Creators: name: Воскресенский Алексей Дмитриевич
Publisher: name: Сравнительная политика
Year: 2018
Subjects: Евразия; Россия; Китай; КНР; ЕС; российскокитайские отношения; китайско-российские отношения; китайско-американские отношения; Тихоокеанская Азия; ИндоПасифика; Азиатско-Тихоокеанский регион; АТР; китайская модель развития; региональные проекты Евразии

description: Редакция журнала «Сравнительная политика» публикует вторую часть материалов ситуационного анализа в форме сценируемого круглого стола, посвященного результатам анализа динамики и современного состояния развития российскокитайских отношений и развития ситуации в АТР. На мероприятии выступили и приняли участие в дискуссии исследователи Центра комплексного китаеведения и региональных проектов МГИМО МИД России, Института Дальнего Востока РАН, Института Востоковедения РАН, Российского института стратегических исследований (РИСИ), Института политического и военного анализа, Института экономики РАН, ИМЭМО им. Е.М. Примакова РАН, НИУ ВШЭ, Национального комитета БРИКС. Ведущие российские эксперты обсудили современное состояние и перспективы российско-китайских отношений и эволюцию ситуации в АТР, а также формирование нового функционального ИндоТихоокеанского региона (Индо-Пасифика), проблемы и перспективы новых региональных проектов в Евразии.
title: Rapid Diagnostics for Infectious Disease using Noble Metal Nanoparticles
Creators: name: Yen, Chun-Wan
name: de Puig, Helena
name: Tam, Justina
name: Gómez-Márquez, José
name: Bosch, Irene
name: Gehrke, Lee
name: Hamad-Schifferli, Kimberly
Publisher: name: eScholarship@UMMS
Year: 2016

description: Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses such as dengue, Ebola, chikungunya, and others. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. We present a platform for multiplexed pathogen detection which uses gold or silver nanoparticles conjugated to antibodies to sense the presence of biomarkers for different infectious diseases. We exploit the size-dependent optical properties of Ag NPs to construct a multiplexed paperfluidic lateral flow POC sensor. AgNPs of different sizes were conjugated to antibodies that bind to specific biomarkers. Red AgNPs were conjugated to antibodies that could recognize the glycoprotein for Ebola virus, green AgNPs to those that could recognize nonstructural protein 1 for dengue virus, and orange AgNPs for non structural protein 1 for yellow fever virus. Presence of each of the biomarkers resulted in a different colored band on the test line in the lateral flow test. Thus, we were able to use NP color to distinguish among three pathogens that cause a febrile illness. Because positive test lines can be imaged by eye or a mobile phone camera, the approach is adaptable to low-resource, widely deployable settings. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing. We will also discuss engineering the nanoparticle physical properties and surface chemistry for improving detection and also optimizing device properties, and expansion of the device to detect other diseases.
Density anomaly in water-alcohol mixtures: minimum model for structure makers and breakers
Creators: name: Habitzreuter, Marco A.
name: Barbosa, Marcia C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences
subject: 82B21, 82B80

description: We modeled the change in the temperature of maximum density (TMD) of a water-like solvent when small amounts of solute are added to the mixture. The solvent is modeled as a two length scales potential, which is known to exhibit water-like characteristic anomalies, while the solute is chosen to have an attractive interaction with the solvent which is tuned from small to large attractive potential. We show that if the solute exhibits high attraction with the solvent it behaves as a structure maker and the TMD increases with the addition of solute, while if the solute shows a low attraction with the solvent the TMD decreases, with the solute behaving as a structure breaker.
description: 12 pages, 10 figures. Version accepted for publication in PRE. arXiv admin note: substantial text overlap with arXiv:2204.12448
Observations of highly localized oscillons with multiple crests and troughs
Creators: name: LI, Xiaochen
name: Xu, Dali
name: Liao, Shijun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Two types of stable, highly localized Faraday's resonant standing waves with multiple crests and troughs are observed in the alcoholic solution partly filled in a Hele-Shaw cell vertically oscillated with a single frequency. These oscillons have never been reported. Systematical experiments are performed to investigate the properties of these ocsillons. Especially, some experiments are performed, for the first time, to indicate the high localization of the oscillons, which suggest that these oscillons may be regarded as a combination of the two elementary oscillons discovered by Rajchenbach et al. (Physical Review Letters, 107, 2011), for instance, (2,3) = (1,1) + (1,2), where ($m,n$) denotes oscillon with m crests and n troughs. So, our experiments also reveal an interesting, elegant "arithmetic" of these oscillons.
description: 4 pages, 5 figures, submitted
Assessing the saturation of Krylov complexity as a measure of chaos
Creators: name: Español, Bernardo L.
name: Wisniacki, Diego A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Krylov complexity is a novel approach to study how an operator spreads over a specific basis. Recently, it has been stated that this quantity has a long-time saturation that depends on the amount of chaos in the system. Since this quantity not only depends on the Hamiltonian but also on the chosen operator, in this work we study the level of generality of this hypothesis by studying how the saturation value varies in the integrability to chaos transition when different operators are expanded. To do this, we work with an Ising chain with a transverse-longitudinal magnetic field and compare the saturation of the Krylov complexity with the standard spectral measure of quantum chaos. Our numerical results show that the usefulness of this quantity as a predictor of the chaoticity is strongly dependent on the chosen operator.
description: 7 pages, 8 figures
title: Разработка семейства кремниевых свч биполярных транзисторов с рабочей частотой 3–7 ггц.
Creators: name: Мизева, Д.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: В работе рассмотрены особенности технологии и конструкции семейства СВЧ биполярных транзисторов. Для их изготовления использована кремниевая технология с топологической нормой 1 мкм.
Photospheric emission from long duration gamma-ray bursts powered by variable engines
Creators: name: López-Cámara, Diego
name: Morsony, Brian
name: Lazzati, Davide
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the results of a set of numerical simulations of long-duration gamma-ray burst jets aimed at studying the effect of a variable engine on the peak frequency of the photospheric emission. Our simulations follow the propagation of the jet inside the progenitor star, its break-out, and the subsequent expansion in the environment out to the photospheric radius. A constant and two step-function models are considered for the engine luminosity. We show that our synthetic light-curves follow a luminosity-peak frequency correlation analogous to the Golenetskii correlation found in long-duration gamma-ray burst observations. Within the parameter space explored, it appears that the central engine luminosity profile does not have a significant effect on the location of a gamma-ray burst in the Luminosity-peak frequency plane, bursts from different central engines being indistinguishable from each other.
description: 7 pages, 6 figures, accepted for publication in MNRAS
Contingency Payment for Industrial Design (adapted from NSPE Case No. 77-12)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Research and Practice

description: Payment for work on a contingency or commission basis is considered by some to undermine the professional standing of engineers, and, in some circumstances, to create a conflict of interest. Others view it as creating an incentive for an engineer to deliver the best services of which she is capable. This is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review.
title: Формирование сквозных металлизированных отверстий в арсенид-галлиевых свч монолитных интегральных схемах
Creators: name: Лукин, В
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: Разработана технология формирования сквозных металлизированных отверстий в арсенид-галлиевых СВЧ монолитных интегральных схемах. Результаты плазмохимического травления анализировались с помощью профилометра. Рассмотрены зависимости средней скорости травления GaAs и фоторезиста от мощности ICP источника и давления в камере.
title: Разработка программно-аппаратного комплекса для автосопровождения движущейся цели в видеопотоке
Creators: name: Кононов, С.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: В работе представлен алгоритм и программное обеспечение для решения задачи автосопровождения движущегося объекта в реальном масштабе времени, устойчивого к перекрытиям основой цели. В качестве основы использована методика на базе корреляционной функции. Для повышения ее эффективности и быстродействия
предложен ряд усовершенствований, включающих использование параллельной обработки информации и повышение устойчивости к перекрытиям основой цели.
The Use of Work from an Unpaid Consultation (adapted from NSPE Case No. 77-5)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Bidding Process
Confidentiality
Ethics and Society
Law and Public Policy
Research and Practice
Social Responsibility
Workplace Ethics

description: This case covers the pursuit of a contract and use of a study authored by a competing firm. It raises questions about the limits that are required in order to keep competition for a contract fair. This is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review.
Delay Analysis of IEEE 802.11be Multi-link Operation under Finite Load
Creators: name: Bellalta, Boris
name: Carrascosa, Marc
name: Galati-Giordano, Lorenzo
name: Geraci, Giovanni
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Multi-link Operation (MLO), arguably the most disruptive feature introduced in IEEE 802.11be, will cater for delay-sensitive applications by using multiple radio interfaces concurrently. In this paper, we analyze the delay distribution of MLO under non-saturated traffic. Our results show that upgrading from legacy single-link to MLO successfully contains the $95$th percentile delay as the traffic load increases, but also that adding extra interfaces yields rapidly diminishing gains. Further experiments we conduct on Google Stadia traces, accounting for realistic traffic with batch arrivals, confirm the insights stemming from our theoretical analysis, vouching for MLO to support high-resolution real-time video with a controlled delay.
การประเมินผลสัมฤทธิ์ของงานเฝ้าระวังป้องกันและควบคุมโรคตามแนวทางการประเมินแบบสมดุลของสำนักงานป้องกันควบคุมโรคที่ 10 ปี 2547
Creators: name: ปิยะดา คุณาวรารักษ์
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2551
Subjects: การประเมินผลสัมฤทธิ์
แนวทางแบบสมดุล
สำนักงานป้องกันควบคุมโรคที่ 10

description: วารสารควบคุมโรค, 34, 4, 397-409
Maintaining Professional Standards: Writing a Letter of Recommendation (adapted from NSPE Case No. 77-7)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Workplace Ethics
Employer/Employee Relationships
Privacy and Surveillance

description: This is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review. It discusses the nature of the obligation to write letters of recommendation and the value of professional-society membership in one engineer's respect for another.
Vortex Transport and Pinning Effectiveness in Conformal Pinning Arrays
Creators: name: Ray, D.
name: Reichhardt, C.
name: Reichhardt, C. J. Olson
name: Janko, B.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We examine the current driven dynamics for vortices interacting with conformal crystal pinning arrays and compare to the dynamics of vortices driven over random pinning arrays. We find that the pinning is enhanced in the conformal arrays over a wide range of fields, consistent with previous results from flux gradient-driven simulations. At fields above this range, the effectiveness of the pinning in the moving vortex state can be enhanced in the random arrays compared to the conformal arrays, leading to crossing of the velocity-force curves.
description: 7 pages, 6 postscript figures
Related Work Done by a Private Party Following Public Employment (adapted from NSPE Case No. 78-10)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Employer/Employee Relationships
Engineer/Client Relationships
Intellectual Property and Patents
Research and Practice
Workplace Ethics
Conflict of Interest
Expert Witness

description: The situation of engineers leaving public employ and then working in the same area in the private sector is a delicate issue. The engineer has had access to government knowledge that a private client may desire. This case is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review that raises questions about the ethical permissibility of such employment.
Planar array of self-assembled Ga$_{x}$Fe$_{4-x}$N nanocrystals in GaN: Magnetic anisotropy determined via ferromagnetic resonance
Creators: name: Grois, Andreas
name: Devillers, Thibaut
name: Li, Tian
name: Bonanni, Alberta
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The magnetic anisotropy of a planar array of Ga$_{x}$Fe$_{4-x}$N nanocrystals (NCs) embedded in a GaN host is studied by ferromagnetic resonance. X-ray diffraction and transmission electron microscopy are employed to determine the phase and distribution of the nanocrystals. The magnetic anisotropy is found to be primarily uniaxial with the hard axis normal to the NCs plane and to have a comparably weak in-plane hexagonal symmetry. The origin of the magnetic anisotropy is discussed taking into consideration the morphology of the nanocrystals, the epitaxial relations, strain effects and magnetic coupling between the NCs.
description: 14 pages, 3 figures, 1 table (Preprint formatting); 2 pages additional material (Preprint formatting)
title: Older women’s muscle and gait response to a bout of exercise differs by physical activity level
Creators: name: Hafer, Jocelyn F.
name: Boyer, Katherine A.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Changes in gait are a consequence of aging and likely contribute to knee osteoarthritis (OA) incidence. Decrements in muscle function with age, including muscle power and fatigue resistance, may contribute to changes in gait and, subsequently, knee OA. Examining the impact of habitual physical activity (PA) on gait mechanics and muscle function may provide insight for interventions to modify knee OA risk. As knee OA affects women at greater rates than men, the current study focused on older women. The aim of this study was to determine if older women with different levels of habitual PA experienced the same effect, in terms of muscle function and gait biomechanics, in response to 30 minutes of treadmill walking (30MTW). We hypothesized that sedentary women (SED) would display greater decreases in knee extensor strength and power and larger changes in gait biomechanics compared to highly active women (ACT). Twelve women (6 SED, 6 ACT) aged 61.3±3.9 years with BMI 22.3±2.2 participated in this study. Gait mechanics and knee extensor strength and power were collected pre- and post-30MTW. Unpaired t-tests were used to compare changes in knee extensor function and gait mechanics between SED and ACT with significance set at p<0.1. In response to the 30MTW, there was a larger decrease in high-velocity knee extensor power for SED vs. ACT (-26.3±12.2 vs. -12.9±13.7%). In addition, SED compared to ACT had a larger increase in sagittal hip range of motion during stance (+1.9±2.5 vs. +0.3±0.7°), a larger increase in dorsiflexion at heel strike (+2.2±1.7 vs. +0.3±2.3°), a larger decrease in plantarflexion at toe-off (-1.6±2.5 vs. +0.9±1.9°), and a larger decrease in anterior position of the femur relative to the tibia during loading response (-2.6±4.0 vs. +0.5±2.9 mm). These findings suggest PA level may affect biomechanical health in older women, especially with regard to exercise-induced fatigue.
title: Racial/Ethnic Disparities in Meeting 5-2-1-0 Recommendations among Adolescents in the United States
Creators: name: Haughton, Christina F.
name: Wang, Monica
name: Lemon, Stephenie C.
Publisher: name: eScholarship@UMMS
Year: 2016

description: BACKGROUND: Obesity prevention has become a major focus of public health efforts in the United States. The Federal Government set forth national nutrition and physical activity recommendations to prevent obesity and promote well-being among children. A succinct message developed through a program in Maine “Let’s Go! 5-2-1-0” summarizes these obesity prevention behaviors including ≥5 fruit and vegetables, ≤2 hours of screen time, ≥1 hour of physical activity, and 0 sugar sweetened beverages daily. The study evaluates racial/ethnic disparities among adolescents meeting the 5-2-1-0 targets in a nationally representative sample.

METHODS: The 2011-2012 NHANES dataset was used to conduct a cross sectional analysis of Hispanic (n=287), non-Hispanic Black (n=321), Asian (n=145) and non-Hispanic White (n=234) adolescents 12-19 years old. The 5-2-1-0 targets were evaluated using dietary recalls, Global Physical Activity Questionnaire, and questions about sedentary activities. Differences in the proportion of racial/ethnic groups meeting the 5-2-1-0 targets were compared using chi-square tests. Logistic models accounting for the complex sampling design were used to evaluate racial/ethnic disparities in meeting the 5-2-1-0 targets.

RESULTS: There were no adolescents that met all four 5-2-1-0 targets. Meeting individual targets and meeting none of the targets differed by racial/ethnic group. The study found 28% of White, 39% of Hispanic, 44% of Black and 35% of Asian adolescents met zero 5-2-1-0 targets. Adolescents from different racial/ethnic groups had increased odds of meeting no 5-2-1-0 targets compared to their White peers (adjusted odds ratio [95% Confidence Interval] – Hispanic: 1.76 [1.04-2.98], Black: 1.82[1.04-3.17], Asian: 1.48[1.08-2.04]).

CONCLUSION: Understanding the uptake of national nutrition and physical activity recommendations is necessary to reduce future obesity and health consequences in adulthood. Despite national initiatives, adolescents in the United States are far from meeting the 5-2-1-0 targets and there are racial/ethnic disparities in meeting the recommendations.
title: Analysis of A Novel Nonsense Mutation of Androgen Receptor Gene in Castration-Resistant Prostate Cancer
Creators: name: Han, Dong
name: Valencia, Kevin
name: Gao, Shuai
name: Cai, Changmeng
Publisher: name: eScholarship@UMMS
Year: 2016

description: BACKGROUND: Prostate cancer (PCa) is the second leading cause of cancer mortality in American men. The standard treatment for PCa is androgen deprivation therapy (ADT) that blocks transcriptional activity of androgen receptor, but ADT invariably leads to the development of castration-resistant form of PCa (CRPC) with restored activity of AR. CRPC can be further treated with more intensive ADTs, including CYP17-inhibitors to block intratumoral androgen synthesis and more potent AR antagonist (enzalutamide). Most CRPC patients still relapse after a year of treatment and AR activity appears to be restored again. By analyzing the tumor mRNA from a CRPC patient biopsy who had developed resistance to CYP17-inhibitor treatment, we identified a novel nonsense AR mutation on ligand binding domain (Q784sc), which presumably produces a C-terminal truncated form of AR protein that lacks ligand binding domain (LBD) and may mimic certain AR splice variants that also lack LBD. We thus hypothesized that AR-Q784sc mutant may gain the androgen-independent activity or may enhance the transcriptional activity of full-length AR under low androgen environment through dimerization with full-length AR.

METHOD: We utilized luciferase reporter assays to assess the activity of AR-Q784sc in absence or presence of androgens, and with/out full-length AR. We also examined the protein stability and cellular localization of AR-Q784sc using immunoblotting and immunofluorescence. Moreover, stable cell lines that overexpress AR and/or AR-Q784sc were generated to assess the transcription activity on endogenous target genes and on PCa cell growth.

CONCLUSION: AR-Q784sc mutant produces a LBD truncated AR protein that does not have any transcriptional activity by it alone. However, AR-Q784sc can significantly enhance transcriptional activity of full-length AR though dimerization, indicating that the more intensive ADTs may allow CRPC cells to select for LBD truncated form of AR to further enhance the full-length AR activity under low androgen environment.
Can Cosmological Simulations Reproduce the Spectroscopically Confirmed Galaxies Seen at $z\geq 10$?
Creators: name: Keller, B. W.
name: Munshi, F.
name: Trebitsch, M.
name: Tremmel, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent photometric detections of extreme $(z>10)$ redshift galaxies from the JWST have been shown to be in strong tension with existing simulation models for galaxy formation, and in the most acute case, in tension with $ΛCDM$ itself. These results, however, all rest on the confirmation of these distances by spectroscopy. Recently, the JADES survey has detected the most distant galaxies with spectroscopically confirmed redshifts, with four galaxies found with redshifts between $z=10.38$ and $z=13.2$. In this paper, we compare simulation predictions from four large cosmological volumes and two zoom-in protoclusters with the JADES observations to determine whether these spectroscopically confirmed galaxy detections are in tension with existing models for galaxy formation, or with $ΛCDM$ more broadly. We find that existing models for cosmological galaxy formation can generally reproduce the observations for JADES, in terms of galaxy stellar masses, star formation rates, and the number density of galaxies at $z>10$.
description: Replaced with published version
Binary Service to Same Client (adapted from NSPE Case No. 78-3)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Research and Practice

description: This is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review. Two Engineers co-own both an engineering firm and a consulting firm called Electricity Services. Their engineering firm is awarded an assignment by the board of directors of the water plant on the basis of reports and recommendations provided by their other company, Electricity Services.
Abelian charge inspired by family number
Creators: name: Van Dong, Phung
name: Hung, Tran Ngoc
name: Van Loi, Duong
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Quark has an electric charge either $-1/3$ or $2/3$ and a baryon number $1/3$, where the divisions $3$'s match the color number. Although the electric charge and the baryon number have a nature distinct from the color charge, the matching is necessary for the standard model or a relevant $B-L$ extension consistent at quantum level, since the relevant anomaly $[SU(2)_L]^2U(1)_A$ for $A=Y$ or $B-L$ must vanish. If elementary particles have a new $U(1)$ charge differently from $A$, such anomaly is not cancelled for each family. However, if we demand that the anomaly is cancelled over all families, this relates the color number to the family number instead of the electric charge and baryon number, and interestingly the family number guides us to a novel $U(1)$ theory. We will discuss the implication of this theory for neutrino mass, recent $W$-boson mass anomaly, FCNC, and particle colliders.
description: 21 pages, 3 figures; Yukawa couplings corrected and presentation improved; Matches journal version
The Flavor Structure of the Nucleon Sea
Creators: name: Peng, J. C.
name: Chang, W. C.
name: Cheng, H. Y.
name: Liu, K. F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss two topics related to the flavor structure of the nucleon sea. The first is on the identification of light-quark intrinsic sea from the comparison between recent data and the intrinsic sea model by Brodsky et al. Good agreement between the theory and data allows a separation of the intrinsic from the extrinsic sea components. The magnitudes of the up, down, and strange intrinsic seas have been extracted. We then discuss the flavor structure and the Bjorken-x dependence of the connected sea (CS) and disconnected sea (DS). We show that recent data together with input from lattice QCD allow a separation of the CS from the DS components of the light quark sea.
description: 8 pages, 6 figures, to appear in the DSPIN-13 Conference Proceedings, Typos corrected
พฤติกรรมการดูแลตนเองและการเกิดภาวะแทรกซ้อนของผู้ป่วยโรคเบาหวาน โรงพยาบาลนภาลัย จังหวัดสมุทรสงคราม
Creators: name: เดชา มีสุข
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2551
Subjects: ผู้ป่วยโรคเบาหวาน
การดูแลตนเอง
โรงพยาบาลนภาลัย

description: วารสารควบคุมโรค, 34, 4, 410-418
title: Crystal protein Cry5B as a novel and powerful anthelmintic
Creators: name: Koch, David
name: Mirza, Zeynep
name: Hu, Yan
name: Nguyen, Thanh-thanh
name: Ostroff, Gary R.
name: Aroian, Raffi V.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Soil-transmitted helminths (STHs), most notably, hookworms, whipworms, and Ascaris, are nematodes that infect more than 1.5 billion of the poorest people and are amongst the leading causes of morbidity worldwide. Only two classes of de-worming drugs (anthelmintics) are available for treatment, and only one is commonly used in mass drug administrations. New anthelmintics are urgently needed to overcome emerging resistance and to produce higher cure rates. Crystal (Cry) proteins, in particular Cry5B, made by Bacillus thuringiensis (Bt) are promising new candidates. Cry5B has excellent anthelmintic properties against many free-living and parasitic nematodes, including in vivo efficacy against multiple STH infections in rodents (Heligomasmidoes polygyrus and Ancylostoma ceylanicum) and in pigs (Ascaris suum).

An enormous challenge for STHs, very different from most diseases worked on in the developing world, is the requirement that therapies be very cheap (the people infected are very poor and current drugs costs pennies a dose), massively scalable (over 4 billion people are at risk from infection), and have a long shelf life in harsh environments, that have high temperature and humidity and no cold chain.

We will update our progress in several key areas. We will present new data on the in vivo activity of Cry5B against a major human parasite in humans. We will also present data on the whether or not the immune system is required for Cry5B action in vivo. We will also present on our development efforts to produce a deployable version of Cry5B that is cheap, safe, scalable, and stable. These efforts are currently focused on bacterial engineering, expression, and formulation.
Effects of ultrafast molecular rotation on collisional decoherence
Creators: name: Milner, Alexander A.
name: Korobenko, Aleksey
name: Hepburn, John W.
name: Milner, Valery
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Using an optical centrifuge to control molecular rotation in an extremely broad range of angular momenta, we study coherent rotational dynamics of nitrogen molecules in the presence of collisions. We cover the range of rotational quantum numbers between J=8 and J=66 at room temperature and study a cross-over between the adiabatic and non-adiabatic regimes of rotational relaxation, which cannot be easily accessed by thermal means. We demonstrate that the rate of rotational decoherence changes by more than an order of magnitude in this range of J values, and show that its dependence on J can be described by a simplified scaling law.
ความต้องการและความคาดหวังของผู้รับผิดชอบงานอาชีวอนามัย ความปลอดภัย และสิ่งแวดล้อมในสำนักงานสาธารณสุขจังหวัด
Creators: name: พนมพันธ์ ศิริวัฒนานุกุล
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2551
Subjects: ความคาดหวัง
สาธารณสุขจังหวัด
อาชีวอนามัยและสิ่งแวดล้อม

description: วารสารควบคุมโรค, 34, 4, 419-433
Danilo Chavez - Proof of a Combinatorial Identity
Creators: name: Chavez, Danilo
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 490404
subject: Combinatorics and discrete mathematics (excl. physical combinatorics)
classificationCode: 490506
subject: Probability theory
classificationCode: 490599
subject: Statistics not elsewhere classified
classificationCode: 490401
subject: Algebra and number theory

description: In this paper we prove an interesting identity involving combinatorial symbols. The theorem was discovered while we were studying Calculus in the ”Mathematics 2” course at the USAC/CUNOC University in Quetzaltenango, Guatemala, between 2002 and 2003. The identity arose from some equations involving the relationship between delta and epsilon for polynomials, in some definitions of calculus, and Newton’s binomial theorem. The completed paper won first place in a demonstration contest at a university science fair, to which we were invited, at the Landivar University on June 13, 2003.
Contribution to Public Works Promotion Committee (adapted from NSPE Case No. 78-4)
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Ethics and Society
Public Well-being
Research and Practice

description: This is an open-ended scenario for discussion based on a case from the NSPE Board of Ethical Review. A promotion committee is organized to finance a variety of public works projects by issuing bonds to the public. They don't know, however, if they should allow engineering firms to contribute funds to the promotion fund.
title: Phytophthora na črničevju (Quercus ilex L.)
Creators: name: Cordobado Sánchez, Tamara
Publisher: name: Julius Kühn-Institut , Federal Research Centre for Cultivated Plants
Year: 2013

description: JKI Data Sheets Plant Pests and Diagnosis; 2013/40
description: Quercus ilex L. (črničevje) je dominantna drevesna vrsta v sredozemski regiji in značilna za tamkajšnje rastlinske združbe (Plieninger et al., 2004; zemljevid razširjenosti Q. ilex glej na http://www.discoverlife.org). Q. ilex je vednozeleno drevo, ki uspeva v različnih podnebnih razmerah (semiaridni, subhumidni, humidni in perhumidni klimi) in na različnih tipih tal. Zraste do 25 m visoko in ima usnjate, spodaj dlakave liste različnih oblik, od skoraj okrogle do izdolžene, z zobci na listnem robu ali ravnim robom. Znani sta dve podvrsti: Q. ilex subsp. ilex in Q. ilex subsp. ballota (sin. Q. rotundifolia). Na Iberskem polotoku je Quercus ilex najpomembnejša drevesna vrsta v tamkajšnjih agrano-gozdnih ekosistemih, imenovanih dehesa. Ti imajo zelo pomembno ekološko, gospodarsko in socialno vlogo saj združujejo prirejo živali, pridobivanje želoda za krmo, lesa za kurjavo in pridelavo žita.
The X-shooter Spectral Library (XSL): I. DR1. Near-ultraviolet through optical spectra from the first year of the survey
Creators: name: Chen, Yan-Ping
name: Trager, S. C.
name: Peletier, R. F.
name: Lançon, A.
name: Vazdekis, A.
name: Prugniel, Ph.
name: Silva, D. R.
name: Gonneau, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first release of XSL, the X-Shooter Spectral Library. This release contains 237 stars spanning the wavelengths 3000--10200 Å observed at a resolving power $R \equiv λ/ Δλ\sim 10000$. The spectra were obtained at ESO's 8-m Very Large Telescope (VLT). The sample contains O -- M, long-period variable (LPV), C and S stars. The spectra are flux-calibrated and telluric-corrected. We describe a new technique for the telluric correction. The wavelength coverage, spectral resolution and spectral type of this library make it well suited to stellar population synthesis of galaxies and clusters, kinematical investigation of stellar systems and studying the physics of cool stars.
description: 41 pages, 38 figures, 5 tables. Accepted for publication in A&A. Webpage: http://xsl.u-strasbg.fr/
title: Theoretical and Experimental Analysis of the Antioxidant and Anti-amyloid Features of Synthetic Resveratrol Mimics
Creators: name: Horton, William
name: Kokel, Anne
name: Török, Fanni
name: Tran, Chris
name: Török, Marianna
name: Török, Bela
Publisher: name: eScholarship@UMMS
Year: 2016

description: Diaryl hydrazones, possessing similar structure to the popular red wine antioxidant resveratrol, have been previously identified as multitarget compounds interfering with several processes associated with the pathogenesis of Alzheimer’s disease (AD). These compounds exhibited particularly strong inhibition of the amyloid beta (A) peptide self-assembly, including blocking the formation of fibrils and oligomers, species that are widely accepted to be neurotoxic. The molecules were also powerful free radical scavengers and thus have a potential to defend against oxidative stress.

In order to learn more about the mode of action of the compounds, theoretical and experimental studies have been carried out. First, the structural, energetic and electronic features of the core structure have been elucidated by density funtional theory (DFT) calculations. The DFT results identified the most likely form of the compounds, which was applied to a broad range of calculations using substituted derivates. Based on the structural information several characteristics such as logP, H-binding energy, HOMO-LUMO energies and band gap and electron densities were calculated. The compounds were subjected to three different antioxidant assays (DPPH, ABTS and ORAC). The % radical scavenging has been analyzed as a function of the above determined structural parameters in order to identify the role of the energetic and electronic features in the antioxidant activity. The analysis of the same parameters as potential markers to the anti-amyloid activity has also been carried out.

Isotope labeling via H-D exchange and in situ hydrazone-radicals as well as hydrazone-A complex formation, applying 1H-NMR and HRMS, have also been used to experimentally observe the potential role of various tautomeric forms and the partially delocalized electron structure of the hydrazones.
null Wirkung von Metformin auf neurodegenerative Prozesse in der ApoE-/- Maus
Creators: name: Brichmann, Elaine
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 610 Medical sciences Medicine

description: Die Alzheimer-Krankheit ist eine Demenzform, die die Bevölkerung im Alter zunehmend betrifft. Erkrankungen wie der Diabetes mellitus und die Dyslipidämie werden mit der AD assoziiert. In tierexperimentellen Studien wies Metformin auch positive Eigenschaften in Hinblick auf die Neurodegeneration auf. Womöglich führt der Metformin induzierte Anstieg von FGF21 via AMPK-mTOR zu einer Neuroprotektion. Wir haben in dieser Arbeit ApoE-/- Mäuse Metformin verabreicht und auf eine mögliche neuroprotektive Wirkung untersucht.
Imaging of Spatial Correlations of Two-Photon States
Creators: name: Bobrov, Ivan B.
name: Kalashnikov, Dmitry A.
name: Krivitsky, Leonid A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We use a fiber based double slit Young interferometer for studying the far-field spatial distribution of the two-photon coincidence rate (coincidence pattern) for various quantum states with different degree of spatial entanglement. The realized experimental approach allows to characterize coincidence patterns for different states without any modifications of the setup. Measurements were carried out with path-entangled and separable states. The dependence of the coincidence pattern on the phase of the interferometer for superposition and separable states was studied. The results have implications for using of nonclassical light in multiphoton imaging, quantum lithography, and studies of phase decoherence.
description: 9 pages, 7 figures; accepted by Phys Rev A
Rossby-wave instability in viscous discs
Creators: name: Gholipour, Mahmoud
name: Nejad-Asghar, Mohsen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Rossby wave instability (RWI), which depends on the density bumps and extremum in the vortensities in the differentially rotating discs, plays an important role in the evolution of the protoplanetary discs. In this article, we investigate the effect of viscosity on the non-axisymmetric RWI in the self-graviting accretion discs. For this purpose, we add the viscosity to the work of Lovelace and Hohlfeld (2013). Consideration of viscosity complicates the problem so that we use the numerical method to investigate the stable and unstable modes. We consider three ranges of viscosities: high viscosity in the ranges $0.1\leq α\leq 0.4$, moderate viscosity in the ranges $0.01\leq α< 0.1$, and low viscosity in the ranges $α< 0.01$. The results show that the occurrence of the RWI is related to the value of viscosity so that the effect of high viscosity is important, while the low viscosity is negligible. These results may be applied for the study of the RWI role in planet formation and angular momentum transport for different kinds of the protoplanetary discs with different viscosities.
description: Accepted for publication in MNRAS. arXiv admin note: text overlap with arXiv:1212.0443 by other authors
title: Remotely Triggered Polymeric Nanoparticles for the Treatment of Triple Negative Breast Cancer
Creators: name: Jadia, Rahul
name: Piel, Brandon
name: Tilton, Michael
name: Rai, Prakash
Publisher: name: eScholarship@UMMS
Year: 2016

description: Triple Negative Breast Cancer (TNBC) has the worst prognosis among all the sub-types of breast cancer. Currently no targeted treatment has been approved for TNBC management. While TNBC does not overexpress hormone receptors, it has been found to over express certain receptors like transferrin (TfR) or folate receptors. The aim of this research is to synthesize targeted polymeric nanoparticles for TNBC. MDA-MB-231 cells are used as a representative TNBC cell line in this study. Active targeting of TNBC is achieved by conjugating the nanoparticles to a peptide (Tr) that binds to the TfR. Photodynamic Therapy (PDT) using polymeric nanoparticles was explored for TNBC treatment. PDT utilizes a secondary form of targeting by remotely triggering benzoporphyrin derivative monoacid (BPD) using near infrared light. When irradiated at 690nm, BPD induces cytotoxicity via generation of reactive oxygen species. The polymeric nanoparticles were characterized for size, zeta potential, and drug release at 37°C. The morphology of the nanoparticles was confirmed using electron microscopy and cell uptake was monitored in vitro using fluorescent microscopy. PDT was carried out at 500nM BPD concentration using a 690nm laser. Cytotoxicity of these targeted polymeric nanoparticles was assessed using a standard colorimetric viability assay (MTT). The nanoparticles synthesized were fairly monodisperse and the release studies demonstrated sustained BPD release from the nanoparticles. Receptor mediated endocytosis of the active nanoparticles was studied by using FITC conjugated peptide and the FITC signal was observed using fluorescent microscopy. Stronger BPD fluorescent signal for the active targeting nanoparticles (PLGA-PEG-Tr) compared to the passive (PLGA-PEG) nanoparticles. Significant cell death following PDT was observed in all the treatment groups, which was also confirmed by imaging the cells post-treatment using standard live-dead stain. PDT is a fairly versatile and non-invasive form of treatment and using targeted nanoparticles it can be adapted for other drugs and diseases.
Improved signal detection algorithms for unevenly sampled data. Six signals in the radial velocity data for GJ876
Creators: name: Jenkins, James S.
name: Yoma, Nestor Becerra
name: Rojo, Patricio
name: Mahu, Rodrigo
name: Wuth, Jorge
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The hunt for Earth analogue planets orbiting Sun-like stars has forced the introduction of novel methods to detect signals at, or below, the level of the intrinsic noise of the observations. We present a new global periodogram method that returns more information than the classic Lomb-Scargle periodogram method for radial velocity signal detection. Our method uses the Minimum Mean Squared Error as a framework to determine the optimal number of genuine signals present in a radial velocity timeseries using a global search algorithm, meaning we can discard noise spikes from the data before follow-up analysis. This method also allows us to determine the phase and amplitude of the signals we detect, meaning we can track these quantities as a function of time to test if the signals are stationary or non-stationary. We apply our method to the radial velocity data for GJ876 as a test system to highlight how the phase information can be used to select against non-stationary sources of detected signals in radial velocity data, such as rotational modulation of star spots. Analysis of this system yields two new statistically significant signals in the combined Keck and HARPS velocities with periods of 10 and 15 days. Although a planet with a period of 15 days would relate to a Laplace resonant chain configuration with three of the other planets (8:4:2:1), we stress that follow-up dynamical analyses are needed to test the reliability of such a six planet system.
description: 30 pages, 9 Figures, 2 Tables, Accepted for publication in MNRAS