cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On the rate of convergence of the 2-D stochastic Leray-$α$ model to the 2-D stochastic Navier-Stokes equations with multiplicative noise
Creators: name: Bessaih, Hakima
name: Razafimandimby, Paul
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H15, 76D05, 60H35

description: In the present paper we study the convergence of the solution of the two dimensional (2-D) stochastic Leray-$α$ model to the solution of the 2-D stochastic Navier-Stokes equations. We are mainly interested in the rate of convergence, as $α$ tends to 0, of the error function which is the difference between the two solutions in an appropriate topology. We show that when properly localized the error function converges in mean square as $α\to 0$ and the convergence is of order $O(α)$. We also prove that the error converges in probability to zero with order at most $O(α)$.
description: Submitted
Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain
Creators: name: Garrett, Christopher K.
name: Neher, Saskia B.
name: Broadwell, Lindsey J.
name: Hayne, Cassandra K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Mycobacterium tuberculosis harbors over 160 genes encoding PE/PPE proteins, several of which have roles in the pathogen’s virulence. A number of PE/PPE proteins are secreted via Type VII secretion systems known as the ESX secretion systems. One PE protein, LipY, has a triglyceride lipase domain in addition to its PE domain. LipY can regulate intracellular triglyceride levels and is also exported to the cell wall by one of the ESX family members, ESX-5. Upon export, LipY’s PE domain is removed by proteolytic cleavage. Studies using cells and crude extracts suggest that LipY’s PE domain not only directs its secretion by ESX-5, but also functions to inhibit its enzymatic activity. Here, we attempt to further elucidate the role of LipY’s PE domain in the regulation of its enzymatic activity. First, we established an improved purification method for several LipY variants using detergent micelles. We then used enzymatic assays to confirm that the PE domain down-regulates LipY activity. The PE domain must be attached to LipY in order to effectively inhibit it. Finally, we determined that full length LipY and the mature lipase lacking the PE domain (LipYΔPE) have similar melting temperatures. Based on our improved purification strategy and activity-based approach, we concluded that LipY’s PE domain down-regulates its enzymatic activity but does not impact the thermal stability of the enzyme.
Social Media and Policy Making How Can Social Media Intervene in Policymaking?
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2022

description: There is a relationship between the collection and analysis of social media data and the quality of public life. The use of public resources, once based on traditional resources in society, is generalized to include the concept of social media. This comes as the conceptualization of the user data and its acceptance by policymakers is viewed as a public resource for engaging users in policymaking to secure public interests. Although data analysis is still in its infancy, the evidence-based policy approach to social media data has dramatically developed. Thus far, policymakers have failed to systematically use social media data in the policymaking process. This is inconsistent with evidence-based policymaking. This special issue aims to expand the theoretical and practical boundaries of research related to the application of social media data in the public sector to improve decisions made by governments.
Charge-density wave, superconductivity and $f$-electron valence instability in EuBiS$_2$F
Creators: name: Zhai, Hui-Fei
name: Tang, Zhang-Tu
name: Jiang, Hao
name: Xu, Kai
name: Zhang, Ke
name: Zhang, Pan
name: Bao, Jin-Ke
name: Sun, Yun-Lei
name: Jiao, Wen-He
name: Nowik, I.
name: Felner, I.
name: Li, Yu-Ke
name: Xu, Xiao-Feng
name: Tao, Qian
name: Feng, Chun-Mu
name: Xu, Zhu-An
name: Cao, Guang-Han
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Superconductivity (SC) and charge-density wave (CDW) are two contrasting yet relevant collective electronic states which have received sustained interest for decades. Here we report that, in a layered europium bismuth sulfofluoride, EuBiS$_2$F, a CDW-like transition occurs at 280 K, below which SC emerges at 0.3 K, without any extrinsic doping. The Eu ions were found to exhibit an anomalously temperature-independent mixed valence of about +2.2, associated with the formation of CDW. The mixed valence of Eu gives rise to self electron doping into the conduction bands mainly consisting of the in-plane Bi-6$p$ states, which in turn brings about the CDW and SC. In particular, the electronic specific-heat coefficient is enhanced by ~ 50 times, owing to the significant hybridizations between Eu-4$f$ and Bi-6$p$ electrons, as verified by band-structure calculations. Thus, EuBiS$_2$F manifests itself as an unprecedented material that simultaneously accommodates SC, CDW and $f$-electron valence instability.
description: 10 pages, 6 figures
Nanometer-thick lateral polyelectrolyte micropatterns induce macrosopic electro-osmotic chaotic fluid instabilities
Creators: name: Wessling, M.
name: Morcillo, L. Garrigós
name: Abdu, S.
Publisher: name: [London] : Macmillan Publishers Limited, part of Springer Nature
Year: 2014
Subjects: subject: concentration polarization
subject: ion transfer
subject: convection
subject: transport
subject: membranes
subject: 500
subject: 600
subject: 540

description: Electro-convective vortices in ion concentration polarization under shear flow have been of practical relevance for desalination processes using electrodialysis. The phenomenon has been scientifically disregarded for decades, but is recently embraced by a growing fluid dynamics community due its complex superposition of multi-scale gradients in electrochemical potential and space charge interacting with emerging complex fluid momentum gradients. While the visualization, quantification and fundamental understanding of the often-chaotic fluid dynamics is evolving rapidly due to sophisticated simulations and experimentation, little is known whether these instabilities can be induced and affected by chemical topological heterogeneity in surface properties. In this letter, we report that polyelectrolyte layers applied as micropatterns on ion exchange membranes induce and facilitate the electro-osmotic fluid instabilities. The findings stimulate a variety of fundamental questions comparable to the complexity of today's turbulence research.
De Haas-van Alphen oscillations in the compensated organic metal alpha-'pseudo-kappa'-(ET)4H3O[Fe(C2O4)3].(C6H4Br2)
Creators: name: Audouard, Alain
name: Canadell, Enric
name: Fortin, Jean-Yves
name: Prokhorova, Tatyana G.
name: Laukhin, Vladimir N.
name: Vignolles, David
name: Yagubskii, Eduard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Field-, temperature- and angle-dependent Fourier amplitude of de Haas-van Alphen (dHvA) oscillations are calculated for compensated two-dimensional (2D) metals with textbook Fermi surface (FS) composed of one hole and two electron orbits connected by magnetic breakdown. It is demonstrated that, taking into account the opposite sign of electron and hole orbits, a given Fourier component involves combination of several orbits, the contribution of which must be included in the calculations. Such FS is observed in the strongly 2D organic metal alpha-'pseudo-kappa'-(ET)4H3O[Fe(C2O4)3].(C6H4Br2), dHvA oscillations of which have been studied up to 55 T for various directions of the magnetic field with respect to the conducting plane. Calculations are in good quantitative agreement with the data.
description: European Physical Journal B (2014)
The Efficiency of Pubmed Query Refinement Suggestions in Comparison with MESH Terms: A Bushehr Medical Specialists Viewpoint
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Purpose: Pubmed is among the most renowned medical databases. It uses MESH as a controlled vocabulary tool for facilitating the search process. Recently it has applied a second suggesting system (keywords and phrases) in this regard. Since information systems aim at retrieving the most relevant results, analyzing the efficiency of this new suggestion system and the old MESH terms from users' point of view would be of importance in this regard. Methodology: As an applied study, this survey has been conducted through distributing a questionnaire during search sessions of users. To this end, a sample of 40 specialists, in the field of medical sciences, was selected through a purposive sampling method and the results were analyzed using SPSS 16.0. Findings: the results show that there is no significant difference between documents relevance when Pubmed suggestions or MESH terms are used during each search session. According to the findings of this study both Pubmed suggestions and MESH terms help the user with better understanding the concept and they both broaden the terminology of users. At the same time both methods are efficient in relevancy of the retrieved documents.
A comprehensive identification of potential molecular targets and small drugs candidate for melanoma cancer using bioinformatics and network-based screening approach
Creators: name: Khan, Dhrubo Ahmed
name: Adhikary, Tonmoy
name: Sultana, Mst. Tania
name: Toukir, Imran Ahamed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Melanoma is the third most common malignant skin tumor and has increased in morbidity and mortality over the previous decade due to its rapid spread into the bloodstream or lymphatic system. This study used integrated bioinformatics and network-based methodologies to reliably identify molecular targets and small molecular medicines that may be more successful for Melanoma diagnosis, prognosis and treatment. The statistical LIMMA approach utilized for bioinformatics analysis in this study found 246 common differentially expressed genes (cDEGs) between case and control samples from two microarray gene-expression datasets (GSE130244 and GSE15605). Protein–protein interaction network study revealed 15 cDEGs (PTK2, STAT1, PNO1, CXCR4, WASL, FN1, RUNX2, SOCS3, ITGA4, GNG2, CDK6, BRAF, AGO2, GTF2H1 and AR) to be critical in the development of melanoma (KGs). According to regulatory network analysis, the most important transcriptional and post-transcriptional regulators of DEGs and hub-DEGs are ten transcription factors and three miRNAs. We discovered the pathogenetic mechanisms of MC by studying DEGs’ biological processes, molecular function, cellular components and KEGG pathways. We used molecular docking and dynamics modeling to select the four most expressed genes responsible for melanoma malignancy to identify therapeutic candidates. Then, utilizing the Connectivity Map (CMap) database, we analyzed the top 4-hub-DEGs-guided repurposable drugs. We validated four melanoma cancer drugs (Fisetin, Epicatechin Gallate, 1237586-97-8 and PF 431396) using molecular dynamics simulation with their target proteins. As a result, the results of this study may provide resources to researchers and medical professionals for the wet-lab validation of MC diagnosis, prognosis and treatments. Communicated by Ramaswamy H. Sarma
Monetary Value of Diet Is Associated with Dietary Quality and Nutrient Adequacy among Urban Adults, Differentially by Sex, Race and Poverty Status
Creators: name: Beydoun, May A.
name: Popkin, Barry M.
name: Fanelli-Kuczmarski, Marie T.
name: Evans, Michele K.
name: Zonderman, Alan B.
name: Beydoun, Hind A.
name: Allen, Allyssa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ObjectiveThe association between monetary value of the diet (MVD, $/day) with dietary quality was examined using a large sample of urban US adults, differentially by socio-demographic factors.MethodsThis was a cross-sectional study of 2,111 participants, aged 30–64y, using data from the Healthy Aging in Neighborhoods of Diversity across the Life Span Study. Dietary quality indices included Healthy Eating Index–2010 (HEI–2010) and Mean Adequacy Ratio (MAR), (two 24-hr recalls). A national food price database was used to estimate MVD. Multiple linear/logistic regression analyses were conducted stratifying separately by sex, race and poverty status.ResultsWomen had significantly higher HEI-2010 scores than men (43.35 vs 41.57 out of 100, respectively), whereas MAR scores were higher for men (76.8 vs 69.9, out of 100), reflecting energy intake gender differentials. Importantly, a $3/day higher MVD (IQR: $3.70/d (Q1) to $6.62/d (Q4)) was associated with a 4.98±0.35 higher total HEI-2010 and a 3.88±0.37 higher MAR score, after energy-adjustment and control for key confounders. For HEI-2010 and MAR, stronger associations were observed among participants above poverty and among women, whilethe MVD vs. HEI-2010 association was additionally stronger among Whites. Sex and poverty status differentials were observed for many MAR and some HEI-2010 components.ConclusionsDespite positive associations between measures of dietary quality and MVD, particularly above poverty and among women, approaching compliance with the Dietary Guidelines (80 or more for HEI-2010) requires a substantially higher MVD. Thus, nutrition education may further improve people’s decision-making regarding food venues and dietary choices.
Förderung der sozialen Kommunikation und sozialen Interaktion bei Kindern im Autismus- Spektrum in der Heilpädagogischen Früherziehung
Creators: name: Spoerle, Julia
name: Peterhans, Nadja
Publisher: name: Zenodo
Year: 2022
Subjects: Sonderpädagogik
Masterarbeit
Autismus- Spektrum
soziale Interaktion
Früherziehung

description: Die vorliegende Arbeit befasst sich mit der Fragestellung, wie die Entwicklung der sozialen Kommunikation und der sozialen Interaktion bei Kindern im Autismus-Spektrum gefördert werden kann und wie die Fachpersonen der Heilpädagogischen Früherziehung die Kinder dabei unterstützen. Dazu wurden mit den Fachpersonen Gruppeninterviews durchgeführt. Anhand der qualitativen Inhaltsanalyse wurden die Aussagen ausgewertet und mit den erarbeiteten theoretischen Grundlagen verglichen. Vor dem Hintergrund, dass Freude und Motivation des Kindes zur Kommunikation und Interaktion für die Entwicklung als zentral angesehen werden, zeigen die Ergebnisse auf, dass die Fachpersonen zur Förderung der Kinder spezifisches Fachwissen nutzen, autismusspezifische Besonderheiten der Kinder in der Förderung berücksichtigen, konkrete Strategien und Hilfsmittel sowie Aspekte aus verschiedenen Förderansätzen und -methoden anwenden und die Eltern in die Förderung einbeziehen.
Mortality Attributable to Low Levels of Education in the United States
Creators: name: Krueger, Patrick M.
name: Hummer, Robert A.
name: Chang, Virginia W.
name: Tran, Melanie K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: BackgroundEducational disparities in U.S. adult mortality are large and have widened across birth cohorts. We consider three policy relevant scenarios and estimate the mortality attributable to: (1) individuals having less than a high school degree rather than a high school degree, (2) individuals having some college rather than a baccalaureate degree, and (3) individuals having anything less than a baccalaureate degree rather than a baccalaureate degree, using educational disparities specific to the 1925, 1935, and 1945 cohorts.MethodsWe use the National Health Interview Survey data (1986–2004) linked to prospective mortality through 2006 (N=1,008,949), and discrete-time survival models, to estimate education- and cohort-specific mortality rates. We use those mortality rates and data on the 2010 U.S. population from the American Community Survey, to calculate annual attributable mortality estimates.ResultsIf adults aged 25–85 in the 2010 U.S. population experienced the educational disparities in mortality observed in the 1945 cohort, 145,243 deaths could be attributed to individuals having less than a high school degree rather than a high school degree, 110,068 deaths could be attributed to individuals having some college rather than a baccalaureate degree, and 554,525 deaths could be attributed to individuals having anything less than a baccalaureate degree rather than a baccalaureate degree. Widening educational disparities between the 1925 and 1945 cohorts result in a doubling of attributable mortality. Mortality attributable to having less than a high school degree is proportionally similar among women and men and among non-Hispanic blacks and whites, and is greater for cardiovascular disease than for cancer.ConclusionsMortality attributable to low education is comparable in magnitude to mortality attributable to individuals being current rather than former smokers. Existing research suggests that a substantial part of the association between education and mortality is causal. Thus, policies that increase education could significantly reduce adult mortality.
title: Smart integrated circuits using machine learning to detect falls in the elderly
Creators: name: Górecki, Sebastian
name: Gajewski, Robert
name: Sulak, Edyta
name: Tatka, Aleksandra
name: Przybył, Szymon
name: Dolny, Rafał
name: Błaszczyk, Grzegorz
Publisher: name: Publishing House of Poznan University of Technology
Year: 2023

description: 5th Conference on Biomedical Engineering. Book of Abstracts, 33-34
MRI-Based Intelligence Quotient (IQ) Estimation with Sparse Learning
Creators: name: Tang, Xiaoying
name: Shen, Dinggang
name: Wee, Chong-Yaw
name: Wang, Liye
name: Suk, Heung-Il
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In this paper, we propose a novel framework for IQ estimation using Magnetic Resonance Imaging (MRI) data. In particular, we devise a new feature selection method based on an extended dirty model for jointly considering both element-wise sparsity and group-wise sparsity. Meanwhile, due to the absence of large dataset with consistent scanning protocols for the IQ estimation, we integrate multiple datasets scanned from different sites with different scanning parameters and protocols. In this way, there is large variability in these different datasets. To address this issue, we design a two-step procedure for 1) first identifying the possible scanning site for each testing subject and 2) then estimating the testing subject’s IQ by using a specific estimator designed for that scanning site. We perform two experiments to test the performance of our method by using the MRI data collected from 164 typically developing children between 6 and 15 years old. In the first experiment, we use a multi-kernel Support Vector Regression (SVR) for estimating IQ values, and obtain an average correlation coefficient of 0.718 and also an average root mean square error of 8.695 between the true IQs and the estimated ones. In the second experiment, we use a single-kernel SVR for IQ estimation, and achieve an average correlation coefficient of 0.684 and an average root mean square error of 9.166. All these results show the effectiveness of using imaging data for IQ prediction, which is rarely done in the field according to our knowledge.
N=2* Super-Yang-Mills Theory at Strong Coupling
Creators: name: Chen-Lin, Xinyi
name: Gordon, James
name: Zarembo, Konstantin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The planar N=2* Super-Yang-Mills (SYM) theory is solved at large 't Hooft coupling using localization on S(4). The solution permits detailed investigation of the resonance phenomena responsible for quantum phase transitions in infinite volume, and leads to quantitative predictions for the semiclassical string dual of the N=2* theory.
description: 34 pages, 9 figures; v2: the name of one author changed
Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia
Creators: name: Oladosu, Folabomi A.
name: Slade, Gary D.
name: Rashid, Naim U.
name: Conrad, Matthew S.
name: Nackley, Andrea G.
name: O’Buckley, Sandra C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A subset of the population receiving opioids for the treatment of acute and chronic clinical pain develops a paradoxical increase in pain sensitivity known as opioid-induced hyperalgesia. Given that opioid analgesics are one of few treatments available against clinical pain, it is critical to determine the key molecular mechanisms that drive opioid-induced hyperalgesia in order to reduce its prevalence. Recent evidence implicates a splice variant of the mu opioid receptor known as MOR-1K in the emergence of opioid-induced hyperalgesia. Results from human genetic association and cell signaling studies demonstrate that MOR-1K contributes to decreased opioid analgesic responses and produces increased cellular activity via Gs signaling. Here, we conducted the first study to directly test the role of MOR-1K in opioid-induced hyperalgesia.
title: Learning to teach critical thinking in Higher Education
Creators: name: Wason, Hilary
Publisher: name: The Open University
Year: 2023

description: This study has explored how educators learn to teach criticality. The impetus for the research came from my own teaching where I noticed that educators lacked access to support in teaching critical thinking. It has investigated what helped their learning, the challenges they faced and what professional development they might need. This study is situated within a relativist ontology and pragmatic social constructivist framework, and is guided by transformative and experiential learning, and threshold concepts theory. A qualitative case study has collected data from 14 educators from a range of disciplines, using semi-structured interviews, peer to peer observations, followed by professional learning conversations and focus groups. Reflexive thematic analysis has been used to identify five key themes: learning through experience; connections and collaborations; pedagogy and common language; resistance and fragility and authentic professional learning. Findings indicate how educators were developing the skills, knowledge and teaching behaviours to teach critical thinking. Their learning had been helped by critically reflecting on their teaching experiences and using a common language and pedagogy of critical thinking. Educators needed the support of a collaborative teaching culture and a connected curriculum. Their learning was challenged by academic and student resistance and pedagogic fragility. Educators valued authentic professional development, for example co-constructing teaching examples and participating in action learning and communities of practice. This study offers an enhancement to an existing framework for professional learning called ‘A Framework for Learning to Teach Critical Thinking’. It makes a contribution to transformative learning, experiential learning, and threshold concepts theory. It adds to the methodological literature by providing a unique intersection of data collection instruments. Finally, it recommends that teaching toolkits, action learning sets, professional learning conversations, dialogic teaching and a collaborative teaching environment can support educators to learn to teach critical thinking.
title: ОПЫТ ИСПОЛЬЗОВАНИЯ НОВОЙ ХРОМОГЕННОЙ ПИТАТЕЛЬНОЙ СРЕДЫ  И ПЕРСПЕКТИВЫ ЕЕ ВНЕДРЕНИЯ  В МИКРОБИОЛОГИЧЕСКУЮ ЛАБОРАТОРНУЮ ПРАКТИКУ
Creators: name: Горелова, Виктория Геннадьевна
name: Омарова, Салидат Магомедовна
name: Исаева, Роза Изитдиновна
name: Алиева, Амина Исаагаевна
name: Глухова, Марина Ивановна
name: Юнусова, Раисат Юнусовна
name: Саидова, Патимат Садрудиновна
name: Багандова, Джамиля Шамильевна
Publisher: name: Астраханский государственный медицинский университет
Year: 2022
Subjects: subject: Clinical medicine
subject: FOS: Clinical medicine

description: На протяжении последних лет во всем мире отмечается рост заболеваний, вызываемых условно-патогенными микроорганизмами. Для их выявления используются различные дифференциально-диагностические питательные среды и микротест-системы, недостатками которых являются продолжительность исследования и значительные материальные затраты. Использование хромогенных питательных сред за рубежом со второй половины ХХ века позволило решить эту задачу на основе выявления высоко специфических ферментов бактерий, что обеспечило идентификацию возбудителя одновременно с его выделением. Цель работы: оценка диагностической эффективности новой хромогенной питательной среды для одноэтапного выделения и идентификации условно-патогенных микроорганизмов и перспективы ее внедрения в микробиологическую лабораторную практику. Результаты. В ходе клинических испытаний новой среды определено, что она не уступает импортной хромогенной питательной среде HiCromетм UTI Agar/Modified («HiMedia Laboratories Pvt. Ltd.», Индия) и превосходит по дифференцирующим свойствам отечественную коммерческую среду Эндо. Разработанная среда защищена патентом Российской Федерации и награждена Золотой медалью Европейского Конкурса изобретений (г. Страсбург, 2014 г.).
Mutation of Androgen Receptor N-Terminal Phosphorylation Site Tyr-267 Leads to Inhibition of Nuclear Translocation and DNA Binding
Creators: name: Parker, Joel S.
name: De Silva, Dinuka
name: Zhang, Zhentao
name: Karaca, Mehmet
name: Liu, Yuanbo
name: Earp, H. Shelton
name: Whang, Young E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Reactivation of androgen receptor (AR) may drive recurrent prostate cancer in castrate patients. Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers. Ack1 phosphorylates AR at Tyr-267 and possibly Tyr-363, both in the N-terminal transactivation domain. In this study, the role of these phosphorylation sites was investigated by characterizing the phosphorylation site mutants in the context of full length and truncated AR lacking the ligand-binding domain. Y267F and Y363F mutants showed decreased transactivation of reporters. Expression of wild type full length and truncated AR in LNCaP cells increased cell proliferation in androgen-depleted conditions and increased colony formation. However, the Y267F mutant of full length and truncated AR was defective in stimulating cell proliferation. The Y363F mutant was less severely affected than the Y267F mutant. The full length AR Y267F mutant was defective in nuclear translocation induced by androgen or Ack1 kinase. The truncated AR was constitutively localized to the nucleus. Chromatin immunoprecipitation analysis showed that it was recruited to the target enhancers without androgen. The truncated Y267F AR mutant did not exhibit constitutive nuclear localization and androgen enhancer binding activity. These results support the concept that phosphorylation of Tyr-267, and to a lesser extent Tyr-363, is required for AR nuclear translocation and recruitment and DNA binding and provide a rationale for development of novel approaches to inhibit AR activity.
Lexical Disambiguation of Polysemeous Adjectives in MT : A Corpus Based Study
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Ambiguous nouns and adjectives are words with more than one meaning. Having several meanings creates problems in MT particularly in automatic programs where human plays no role in choosing the equivalent target word and there is no context available to the machine. One of the ways to solve the problem is to provide the Machine with proper and enough contexts here by context we mean the collocations of a word.. In order to show this we chose English adjectives for our study. We extracted polysemous adjectives from a bilingual English-Persian Middle Dictionary (Hezareh) and checked them all in a bilingual parallel English-Persian Corpus to get the context and collocations for each adjective. Then we recorded all the adjectives with their associate words, context and the meaning provided by the corpus. Then a concordance was created out of these adjectives and their equivalents along with their collocations and a disambiguating program was written for it so that it could choose the best equivalent for the target adjective according to the highest meaning frequency of the given adjective or its collocation. This program’s reliability was tested by using five translators. Their choices were compared through a statistical method (Cronbach alpha) and their covariance was calculated by spss software. The results show that in more than 50% of the cases translators’ choices were the same as the program’s choices. The results of this study could be helpful in MT, bilingual information retrieval, word nets and even in teaching Persian to foreigners.
Databasing on Demand and Federated Search in Manuscript Databases
Creators: name: Melzer, Sylvia
name: Schiff, Simon
name: Möller, Ralf
Publisher: name: Universität Hamburg
Year: 2022
Subjects: CSMC
UWA
Data Linking
DL01
federated search
databasing on demand
EpiDoc
TEI
RFF

description: This seminar showed how to create and link databases into a federated database system.
 The challenges that have to be overcome in order to build such a system were also shown. However, to implement a federated system, one needs databases. Many humanities researchers do not always have one yet. The data is stored in Word documents or perhaps in TEI, EpiDoc, or other formats. Rather than manually typing the research data into a database, this seminar will show how to get a lot of data into database instance in a short period of time and how to link these databases together to form a federated database system to perform federated searches. This results in more time to concentrate on the research questions.
description: The research for this contribution was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796.
title: The Identification and Synthesis of Novel Fluorine Containing Heterocycles as Starting-Points of Fragment-Based Drug Discovery
titleType: Other
Creators: name: Preston, Fergus
Publisher: name: University of Dundee
Year: 2023

description: This thesis describes an approach to the identification, design and synthesis of novel fluorine containing heterocyclic fragments to be used as starting points for FragmentBased Drug Discovery programmes. Heterocyclic motifs are common in medicinal chemistry due to their robust synthesis and available chemical transformations. Fluorine incorporation into heterocyclic structures can modulate many physicochemical properties of a compound, not least its ability to block a metabolically labile hotspot. (Chapter 1).

Herein is detailed the filtering of a generated database (GDB) of 26 million compounds to identify a dataset of 11,596 unreported, undocumented fluorinated heterocycles. With the use of a novel elaboratability programme (developed by James Davidson at Vernalis Research Ltd.), we were able to rank the fragments in terms of how readily they could be elaborated. Additionally, with the use of Pipeline Pilot, we were able to calculate the physicochemical properties of the dataset and compare it to commercial fragment libraries which showed that the fragments followed the “Rule of 3” guidelines for fragments. Applying a principal moment of inertia (PMI) plot for the dataset and comparing it to commercial libraries, we demonstrated that we are exploring underreported chemical space. (Chapter 2).

The synthesis of four of these identified fragments is detailed, including reaction optimisation using design of experiment (DoE) approaches as well as efforts for late-stage fluorine incorporation via both traditional and newer methods, such as C – H functionalisation. (Chapter 3).

Lastly, is the development and optimisation of a new photo-redox assisted decarboxylative fluorination strategy of N-heterocyclic acetic acids to their corresponding fluoromethyl counterparts. (Chapter 4).
Preparing the spinal cord – priming or preconditioning? A systematic review of experimental studies
Creators: name: Herajärvi, Johanna
name: Juvonen, Tatu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: Objectives. Paraplegia is devastating complication associated with thoracic and thoracoabdominal aortic aneurysm repair. Vast evidence has been gathered on pre-, peri- and postoperative protective adjuncts aiming to minimize spinal cord ischemia. This review focuses on the pretreatment phase of open surgical or endovascular aortic procedures and gathers the experimental data on the interventional preconditioning and priming methods that increase the spinal cord ischemic tolerance. Design. By the start of March 2021, a systematic review was performed in PubMed, Scopus and Web of Science core collection to identify the articles that reported (i) either an ischemic preconditioning, remote ischemic preconditioning or priming method prior to (ii) experimental spinal cord ischemia performed in endovascular or open surgical fashion mimicking either thoracic, abdominal or thoracoabdominal aortic aneurysm procedures. (iii) The outcomes were reported via neurological, motor-evoked potential, somatosensory-evoked potential, histopathological, immunohistochemical, physiological analysis, or in different combinations of these measurements. Results. The search yielded 7802 articles, and 57 articles were included in the systematic review. The articles were assessed by the evaluated species, the utilized pretreatment, the measured protective effects, and the suggested underlying mechanisms. Conclusions. The reviewed articles showed several possible mechanisms in ischemic and remote ischemic preconditioning for prevention of spinal cord ischemia. The main suggested method for priming was arteriogenetic stimulus. Future studies should confirm these hints of arteriogenetic stimulus with more precise quantification of the protective recruitment process.
Approaching exact hyperpolarizabilities via sum-over-states Monte Carlo configuration interaction
Creators: name: Coe, J. P.
name: Paterson, M. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We propose using sum-over-states calculations with the compact wavefunctions of Monte Carlo configuration interaction to approach accurate values for higher-order dipole properties up to second hyperpolarizabilities in a controlled way. We apply the approach to small systems that can generally be compared with full configuration interaction (FCI) results. We consider hydrogen fluoride with a 6-31g basis and then look at results, including frequency dependent properties, in an aug-cc-pVDZ basis. We extend one calculation beyond FCI by using an aug-cc-pVTZ basis. The properties of an H$_{4}$ molecule with multireference character are calculated in an aug-cc-pVDZ basis. We then investigate this method on a strongly multireference system with a larger FCI space by modelling the properties of carbon monoxide with a stretched geometry. The behavior of the approach with increasing basis size is considered by calculating results for the neon atom using aug-cc-pVDZ to aug-cc-pVQZ. We finally test if the unusual change in polarizability between the first two states of molecular oxygen can be reproduced by this method in a 6-31g basis.
description: 11 pages, 14 figures
The freshness of Persian Information: the case of Persian Newspapers indexed in Google, Yahoo and Bing
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Aiming to study the freshness of Persian information, the study attempted to explore the indexing speed of Persian newspapers in Google, Yahoo and Bing. The present study was conducted using a webometric method. The population study comprised all the online newspapers published in Persian. The study sample was identified using a targeted method. It included those Persian newspapers listed on the Magiran database with their electronic versions regularly published on their respective websites. The results revealed that Google outperforms the two other search engines in terms of timely indexing the Persian newspapers. Furthermore, it generally enjoys a more consistent and stable indexing model. Yahoo and Bing are not only slower in indexing the newspapers, but also experience a comparably lower consistency level in their indexing models. Yahoo and Bing show to be comparable in their indexing speeds. In this study, the indexing status of Persian newspapers on different internet search engines was investigated for the first time. Results showed that those accessing these newspapers using internet search engines will have a higher chance of accessing their most updated versions using Google.
Network Structure and Biased Variance Estimation in Respondent Driven Sampling
Creators: name: Mouw, Ted
name: Mucha, Peter J.
name: Verdery, Ashton M.
name: Bauldry, Shawn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: This paper explores bias in the estimation of sampling variance in Respondent Driven Sampling (RDS). Prior methodological work on RDS has focused on its problematic assumptions and the biases and inefficiencies of its estimators of the population mean. Nonetheless, researchers have given only slight attention to the topic of estimating sampling variance in RDS, despite the importance of variance estimation for the construction of confidence intervals and hypothesis tests. In this paper, we show that the estimators of RDS sampling variance rely on a critical assumption that the network is First Order Markov (FOM) with respect to the dependent variable of interest. We demonstrate, through intuitive examples, mathematical generalizations, and computational experiments that current RDS variance estimators will always underestimate the population sampling variance of RDS in empirical networks that do not conform to the FOM assumption. Analysis of 215 observed university and school networks from Facebook and Add Health indicates that the FOM assumption is violated in every empirical network we analyze, and that these violations lead to substantially biased RDS estimators of sampling variance. We propose and test two alternative variance estimators that show some promise for reducing biases, but which also illustrate the limits of estimating sampling variance with only partial information on the underlying population social network.
Rational and polynomial representations of Yangians
Creators: name: Khoroshkin, Sergey
name: Nazarov, Maxim
name: Shapiro, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: Representation Theory (math.RT)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: We define natural classes of rational and polynomial representations of the Yangian of the general linear Lie algebra. We also present the classification and explicit realizations of all irreducible rational representations of the Yangian.
description: 23 pages, affiliations updated
Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells
Creators: name: Plevock, Karen M.
name: Galletta, Brian J.
name: Slep, Kevin C.
name: Rusan, Nasser M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. During interphase it has a well-established role within the nucleus as a chromatin insulator. Upon nuclear envelope breakdown, there is a striking redistribution of CP190 to centrosomes and the mitotic spindle, in addition to the population at chromosomes. Here, we investigate CP190 in detail by performing domain analysis in cultured Drosophila S2 cells combined with protein structure determination by X-ray crystallography, in vitro biochemical characterization, and in vivo fixed and live imaging of cp190 mutant flies. Our analysis of CP190 identifies a novel N-terminal centrosome and microtubule (MT) targeting region, sufficient for spindle localization. This region consists of a highly conserved BTB domain and a linker region that serves as the MT binding domain. We present the 2.5 Å resolution structure of the CP190 N-terminal 126 amino acids, which adopts a canonical BTB domain fold and exists as a stable dimer in solution. The ability of the linker region to robustly localize to MTs requires BTB domain-mediated dimerization. Deletion of the linker region using CRISPR significantly alters spindle morphology and leads to DNA segregation errors in the developing Drosophila brain neuroblasts. Collectively, we highlight a multivalent MT-binding architecture in CP190, which confers distinct subcellular cytoskeletal localization and function during mitosis.
A Study on the Sectors of Economy serviced by Pre-industry System Developers among companies in Metro Manila: A Tool for Business Reengineering
Creators: name: Dasig, Daniel D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computers and Society (cs.CY)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: In the emergence of transformative global economy, information system has became a necessity in businesses to obtain organizations operational excellence, adaptation to new business models, improved decision making and providing exceptional customer service, and eventual competitive advantage of the enterprise setting while keeping business alliances. This paper presents sectors of economy serviced by the pre-industry developers, explores the evolution of computer-based information system designed and developed by pre-industry system developers, and examine the effects of an information system in business to countervail indentified recurring problems. Nineteen of forty-six identified sectors of economy falls in the categories of primary, secondary, tertiary, quarternary and quinary were the recipient of computer-based system designed and developed. There have been several effects of computer-based systems to organizations, including the implied relevance to their business processes, continuum process improvement, business process reengineering, business driver and facilitator, and customer satisfaction.
description: 15 pages, 5 figures, 1 table, International Journal of Business Information Systems Strategies (IJBISS) Volume 3, Number 3, August 2014
Obesity Suppresses Estrogen Receptor Beta Expression in Breast Cancer Cells via a HER2-Mediated Pathway
Creators: name: Bowers, Laura W.
name: Hursting, Stephen D.
name: Wiese, Megan
name: deGraffenried, Linda A.
name: Tekmal, Rajeshwar R.
name: Rossi, Emily L.
name: Brenner, Andrew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen receptor beta (ERβ) expression is correlated with improved therapy response and survival. The objective of this study was to determine the impact of obesity on breast cancer cell ERβ expression, which is currently unknown. We utilized an in vitro model of obesity in which breast cancer cells were exposed to patient serum pooled by body mass index category (obese (OB): ≥30 kg/m2; normal weight (N): 18.5–24.9 kg/m2). Four human mammary tumor cell lines representing the major breast cancer subtypes (SKBR3, MCF-7, ZR75, MDA-MB-231) and mammary tumor cells from MMTV-neu mice were used. ERβ expression, assessed by qPCR and western blotting, was suppressed in the two HER2-overexpressing cell lines (SKBR3, MMTV-neu) following OB versus N sera exposure, but did not vary in the other cell lines. Expression of Bcl-2 and cyclin D1, two genes negatively regulated by ERβ, was elevated in SKBR3 cells following exposure to OB versus N sera, but this difference was eliminated when the ERβ gene was silenced with siRNA. Herceptin, a HER2 antagonist, and siRNA to HER2 were used to evaluate the role of HER2 in sera-induced ERβ modulation. SKBR3 cell treatment with OB sera plus Herceptin increased ERβ expression three-fold. Similar results were obtained when HER2 expression was silenced with siRNA. OB sera also promoted greater SKBR3 cell viability and growth, but this variance was not present when ERβ was silenced or the cells were modified to overexpress ERβ. Based on this data, we conclude that obesity-associated systemic factors suppress ERβ expression in breast cancer cells via a HER2-mediated pathway, leading to greater cell viability and growth. Elucidation of the mechanism(s) mediating this effect could provide important insights into how ERβ expression is regulated as well as how obesity promotes a more aggressive disease.
3rd Workshop on Humanities-Centred Artificial Intelligence (CHAI 2023)
Creators: name: Melzer, Sylvia
name: Thiemann, Stefan
name: Peukert, Hagen
Publisher: name: Universität Hamburg
Year: 2023
Subjects: subject: UWA
subject: CSMC
subject: KI2023
subject: AI
subject: RFF
subject: Data Linking
subject: Natural Language Processing
subject: BERT
subject: DL01
subject: CHAI
subject: Humanities
subject: FOS: Humanities
subject: Topic Modelling
subject: Responsible AI
subject: FreSH

description: AI can support research in the Humanities making it easier and more efficient. It is thus essential that AI practitioners and Humanities scholars take a Humanities-centred approach to the development, deployment and application of AI methods for the Humanities. The presentations of the 3rd CHAI workshop were as follows: Hagen Peukert: Keynote: Humanities-Centred AI: Where we are coming from! Where we are heading? Simon Schiff, Ralf Möller: Persistent Data, Sustainable Information (download presentation) Sabrina Göllner, Marina Tropmann-Frick: Bridging the Gap between Theory and Practice: Towards Responsible AI Evaluation (download presentation) Magnus Bender, Kira Schwandt, Ralf Möller, Marcel Gehrke: FrESH – Feedback-reliant Enhancement of Subjective Content Descriptions by Humans (download presentation) Nadja Redzuan, Marcel Gehrke, Ralf Möller, Tanya Braun: On Domain-specific Topic Modelling Using the Case of a Humanities Journal (download presentation) Thomas Asselborn, Sylvia Melzer, Said Aljoumani, Magnus Bender, Florian Andreas Marwitz, Konrad Hirschler, Ralf Möller: Fine-tuning BERT Models on Demand for Information Systems Explained Using Training Data from Pre-modern Arabic (download presentation) Hussein Mohammed: Multimodal Artefacts: Exploring Vision-Language Models to Bridge the Modalities of Historical Written Artefacts (download presentation) Sylvia Melzer, Hagen Peukert, Eliana Dal Sasso, Charles Li, Thomas Asselborn, Ralf Möller: Federated Information Retrieval in Cross-Domain Information Systems (download presentation)
description: The KI2023 workshop – Humanities-Centred AI was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796.