cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pricing methods in outcome-based contracting: δ4: safety-based pricing
Creators: name: Nimer S. Alkhatib
name: Sandipan Bhattacharjee
name: McBride, Ali
name: Ramos, Kenneth
name: Slack, Marion
name: Erstad, Brian
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Six Delta is a six-dimensional independent platform for outcome-based pricing/contracting. The fourth dimension (δ4) estimates prices on the basis of assessments of the safety of the drug using an ex ante analysis based on clinical trial data. We describe this dimension’s methodology and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib. The safety-based pricing dimension utilizes a four-step method: 1) pooling adverse events (AE), standardizing, estimating 95%Cis, and adjusting for time; 2) estimating correction factors and corrected probabilities of AEs; 3) estimating the probability of at least one adverse event (AE) occurring and leading to treatment discontinuation; and 4) estimating ranges for payback percentages and performing Monte Carlo Simulation to estimate a DSPSafety. A proof-of-concept exercise with osimertinib in NSCLC was performed for two hypothetical outcome-based contracts: 1-year (2019–2020) and 2-year (2019–2021). We estimated the DSPSafety based on the grade 3/4 AEs observed for osimertinib and standard of care. The 2018 wholesale acquisition cost (WAC) of osimertinib at $14,616 for a 30-day prescription was used. AEs3/4 were retrieved from the FLAURA trial. In the 1-year contract, the DSPSafety of osimertinib was estimated at $14,627 (or +0.08% the 2018 WAC) for a 30-day prescription. In the 2-year contract, the DSPSafety of osimertinib was estimated at $14,516 (or −0.68% the 2018 WAC) for a 30-day prescription. We demonstrated that ex ante pricing methods-based paybacks for safety issues leading to treatment discontinuation can be integrated into our proposed Six Delta platform for outcome-based pricing/contracting.
Implementation of a new solution to the multivariate Behrens-Fisher problem
Creators: name: Zezula, Ivan
name: Zezula, Ivan
Publisher: name: Unknown
Year: 2009
Subjects: subject: Research Methods/ Statistical Methods
subject: hotelmnm
subject: multivariate Behrens–Fisher problem
subject: Nel and Van der Merwe's test
subject: Welch's test

description: Krishnamoorthy and Yu (2004, Statistics and Probability Letters 66: 161–169) published a new approximate solution to the multivariate Behrens–Fisher problem. It is a modification of Nel and Van der Merwe’s (1986, Communications in Statistics, Theory and Methods 15: 3719–3735) test. The test is invariant and identical to Welch’s test for one-dimensional data. In this article, I describe an implementation of the test in Stata. The hotelmnm command allows you to perform the test easily and returns computed values for possible further computations.
ANALYSIS OF PASTURE SYSTEMS TO MAXIMIZE THE PROFITABILITY AND SUSTAINABILITY OF GRASS-FED BEEF PRODUCTION
Creators: name: Bhandari, Basu Deb
name: Gillespie, Jeffrey M.
name: Scaglia, Guillermo
name: Wang, Jim Jian
name: Bhandari, Basu Deb
name: Gillespie, Jeffrey M.
name: Scaglia, Guillermo
name: Wang, Jim Jian
Publisher: name: Unknown
Year: 2013
Subjects: subject: Production Economics
subject: Grass-fed beef
subject: bermudagrass
subject: ryegrass

description: Three different pasture combinations of grass-fed beef production were evaluated for profitability and sustainability in the Gulf Coast Region. Systems 1 and 2 yielded higher profit than System 3. System 3 produced the lowest greenhouse gas impact. A trade-off was found between profitability and greenhouse gas impact among the systems.
Complex-band structure: a method to determine the off-resonant electron transport in oligomers
Creators: name: Fagas, Giorgos
name: Kambili, Agapi
name: Elstner, Marcus
Publisher: name: arXiv
Year: 2003
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We validate that off-resonant electron transport across {\it ultra-short} oligomer molecular junctions is characterised by a conductance which decays exponentially with length, and we discuss a method to determine the damping factor via the energy spectrum of a periodic structure as a function of complex wavevector. An exact mapping to the complex wavevector is demonstrated by first-principle-based calculations of: a) the conductance of molecular junctions of phenyl-ethynylene wires covalently bonded to graphitic ribbons as a function of the bridge length, and b) the complex-band structure of poly-phenyl-ethynylene.
description: version to appear in Chem Phys Lett; 8 pages, 4 figures; minor changes to the 06/08/03 submission (nomenclature and added concluding remark)
Current Distribution and random matrix ensembles for an integrable asymmetric fragmentation process
Creators: name: Rákos, A.
name: Schütz, G. M.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We calculate the time-evolution of a discrete-time fragmentation process in which clusters of particles break up and reassemble and move stochastically with size-dependent rates. In the continuous-time limit the process turns into the totally asymmetric simple exclusion process (only pieces of size 1 break off a given cluster). We express the exact solution of master equation for the process in terms of a determinant which can be derived using the Bethe ansatz. From this determinant we compute the distribution of the current across an arbitrary bond which after appropriate scaling is given by the distribution of the largest eigenvalue of the Gaussian unitary ensemble of random matrices. This result confirms universality of the scaling form of the current distribution in the KPZ universality class and suggests that there is a link between integrable particle systems and random matrix ensembles.
description: 11 pages
Non-chiral Intermediate Long Wave equation and inter-edge effects in narrow quantum Hall systems
Creators: name: Berntson, Bjorn K.
name: Langmann, Edwin
name: Lenells, Jonatan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We present a non-chiral version of the Intermediate Long Wave (ILW) equation that can model nonlinear waves propagating on two opposite edges of a quantum Hall system, taking into account inter-edge interactions. We obtain exact soliton solutions governed by the hyperbolic Calogero-Moser-Sutherland (CMS) model, and we give a Lax pair, a Hirota form, and conservation laws for this new equation. We also present a periodic non-chiral ILW equation, together with its soliton solutions governed by the elliptic CMS model.
description: 15 pages, 4 figures
Approaches for real-time train delay prediction
Creators: name: Spanninger, Thomas
name: Trivella, Alessio
name: Corman, Francesco
Publisher: name: ETH Zurich
Year: 2020

description: Predicting the delays of trains in real-time is an active area of research with a considerable amount of literature published in recent years. Moreover, increasing availability of historic and live train movement data creates new opportunities and challenges for future research. This paper examines and classifies approaches on train delay prediction in terms of prediction input, type of output, prediction horizon and dynamics of application. This should clear the jungle of the incredible diversity of approaches in this lively area of research and will be the initial point of a discussion of certain advantages and disadvantages of applied methods. Finally we discuss two research gaps and possible enrichments for future analysis and research.
Characterizing the mesh size of polymer solutions via the pore size distribution
Creators: name: Sorichetti, Valerio
name: Hugouvieux, Virginie
name: Kob, Walter
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In order to characterize the geometrical mesh size $ξ$, we simulate a solution of coarse-grained polymers with densities ranging from the dilute to the concentrated regime and for different chain lengths. Conventional ways to estimate $ξ$ rely either on scaling assumptions which give $ξ$ only up to an unknown multiplicative factor, or on measurements of the monomer density fluctuation correlation length $ξ_c$. We determine $ξ_c$ from the monomer structure factor and from the radial distribution function, and find that the identification $ξ=ξ_c$ is not justified outside of the semidilute regime. In order to better characterize $ξ$, we compute the pore size distribution (PSD) following two different definitions, one by Torquato et al. (Ref.1) and one by Gubbins et al. (Ref.2). We show that the mean values of the two distributions, $\langle r \rangle_T$ and $\langle r \rangle_G$, both display the behavior predicted for $ξ$ by scaling theory, and argue that $ξ$ can be identified with either one of these quantities. This identification allows to interpret the PSD as the distribution of mesh sizes, a quantity which conventional methods cannot access. Finally, we show that it is possible to map a polymer solution on a system of hard or overlapping spheres, for which Torquato's PSD can be computed analytically and reproduces accurately the PSD of the solution. We give an expression that allows $\langle r \rangle_T$ to be estimated with great accuracy in the semidilute regime by knowing only the radius of gyration and the density of the polymers.
Additional file 1 of A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
Creators: name: Gingrich, Ellen C.
name: Case, Kendra
name: Garcia, A. Denise R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1 Supplemental Fig. 1. Marked cells show characteristics of transitional radial glia. (A) Brightfield immunostaining for RFP in the cortex of a mouse at P3 after receiving tamoxifen at P0 showing many cells with transitional morphologies and the appearance of residual radial glial fibers. Scale bar, 25 μm (B-F) Colocalization of tdTom (C, red), vimentin (D, green), and BrdU (E, gray) in the cortex of Gli1CreER/+;Ai14 mice at P3 after tamoxifen at P0. Merged image in (B), single channel images in C-F.
Mata Matters: File processing
Creators: name: Gould, William
name: Gould, William
Publisher: name: Unknown
Year: 2009
Subjects: subject: Research Methods/ Statistical Methods
subject: Mata
subject: I/O
subject: string processing
subject: file processing
subject: structures

description: Mata is Stata’s matrix language. In the Mata Matters column, we show how Mata can be used interactively to solve problems and as a programming language to add new features to Stata. The subject of this column is using Mata to read into Stata datasets that are formatted difficultly, which involves Mata’s file processing and string processing capabilities.
Additional file 3 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista L.
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: Supplemental Table 3. Risk of mortality associated with opioid dose among adults on hemodialysis with ≥1 opioid prescriptions, 2007–2014* (N = 232,546).
Amaurochrous dubius
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Amaurochrous
Amaurochrous dubius

description: Amaurochrous dubius (Palisot de Beauvois, 1805)
 New state record: North Carolina: Craven Co.: Fairfield Harbour, wet deciduous woods, 11-13-V-1994, D. C. Marshall (1♂ UMMZ). Texas: Nueces Co.: Port Aransas, 9-IV-1984, S. G. Wellso, det. D. A. Rider (1♀ MSUC).
 Distribution: United States: FL, LA, MS (Lago & Testa 2000), NC, TX. (West Indies)
 Comments: Apparently, this is a more southern form. Barber & Sailer (1953) indicated that they had examined specimens only from Cuba, Florida, and Louisiana (which was followed by Froeschner 1988). It appears that many early workers confused this species with Amaurochrous cinctipes or the next species, Amaurochrous magnus (see comments under those species). We have chosen to omit the older records of Amaurochrous dubius from more northern states.
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 47, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
Modelling one-way electric carsharing in the city of Shanghai, China
Creators: name: Wang, Daoge
name: Ye, Jianhong
name: Axhausen, Kay W.
Publisher: name: ETH Zurich
Year: 2020
Subjects: One-way carsharing
Agent-based model
Electric vehicles
Simulation
MATSim

description: As carsharing is developing rapidly worldwide, carsharing demand estimation becomes a more and more important issue, especially for an area that just introduces this service. Station-based one-way carsharing, as a new carsharing type, recently developed rapidly in China. Both policy-maker and operator want to know how the demand changes with increasing supply. To enrich understanding of these problems, this paper aims to make use of the muti-agent simulation tool (MATSim) to model and simulate one-way carsharing. The largest carsharing project in Shanghai, Evcard, is explicitly analyzed. Specifically, it intends to integrate the mobile phone GSM (Global System for Mobile Communications) data, point of interest data, network data and travel survey data to build a base simulation scenario with about 160,000 agents in the Jiading district, Shanghai. More data, for example the empirical data of operator, are used to calibrate the model. Some special functions, for example, the carsharing vehicles in simulation are pure battery electric vehicles, have been integrated into MATSim. Some preliminary results are presented and validated.
Periodic orbits in analytically perturbed Poisson systems
Creators: name: García, Isaac A.
name: Hernández-Bermejo, Benito
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: Symplectic Geometry (math.SG)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Analytical perturbations of a family of finite-dimensional Poisson systems are considered. It is shown that the family is analytically orbitally conjugate in $U \subset \mathbb{R}^n$ to a planar harmonic oscillator defined on the symplectic leaves. As a consequence, the perturbed vector field can be transformed in the domain $U$ to the Lagrange standard form. On the latter, use can be made of averaging theory up to second order to study the existence, number and bifurcation phenomena of periodic orbits. Examples are given ranging from harmonic oscillators with a potential and Duffing oscillators, to a kind of zero-Hopf singularity analytic normal form.
Assessing the Impact of Internet Access on Household Income and Financial Performance of Small Farms
Creators: name: Khanal, Aditya R.
name: Mishra, Ashok K.
name: Khanal, Aditya R.
name: Mishra, Ashok K.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Agricultural Finance
subject: Community/Rural/Urban Development
subject: Consumer/Household Economics
subject: Small farms
subject: household income
subject: financial performance
subject: average treatment effect
subject: Internet

description: With increased focus on survival strategies for small farm businesses, we investigate the impact of Internet access on income and farm expenses of small farm business and households. Using a nation-wide farm-level data in the U.S. and non-parametric matching estimators, the study finds a significant positive impact of Internet access on total household and off-farm income.
Green synthesis of diethyl((2-iodo-4-(trifluoromethyl)phenyl)amino)(aryl)methyl)phosphonates as potent α-glucosidase inhibitors
Creators: name: Mahammad Sadik Shaik
name: Maheshwara Reddy Nadiveedhi
name: Gundluru, Mohan
name: Sreelakshmi Poola
name: Rajasekhar Allagadda
name: Appa Rao Chippada
name: Cirandur, Suresh Reddy
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Novel diethyl((2-iodo-4-(trifluoromethyl)phenyl)amino)(aryl)methyl)phosphonates (4a-j) were synthesized via a simple and efficient one pot by three-component condensation reaction (Kabachnik-Fields reaction) of 2-iodo-4-trifluoromethyl aniline, aromatic aldehydes and diethyl phosphite in presence of anatase TiO2 nanoparticles as catalyst under solvent free conditions. The molecular docking studies of synthesized compounds with α-glucosidase enzyme revealed that these compounds have strong α-glucosidase inhibitory activity. The synthesized compounds (4a-j) are also screened for in vitro α-glucosidase inhibitory activity and the results showed compound 4i as the strongest inhibitor and compounds 4a, 4b, 4f and 4g as stronger inhibitors even better than the reference standard acarbose.
Electron Transport in Granular Metals
Creators: name: Altland, Alexander
name: Glazman, Leonid I.
name: Kamenev, Alex
Publisher: name: arXiv
Year: 2003
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider thermodynamic and transport properties of a long granular array with strongly connected grains (inter-grain conductance g>>1.) We find that the system exhibits activated behavior of conductance and thermodynamic density of states ~exp(-T*/T) where the gap, T*, is parametrically larger than the energy at which conventional perturbation theory breaks down. The scale T* represents energy needed to create a long single-electron charge soliton propagating through the array.
description: 4 pages, 1 figure
A non-degenerate exchange move always produces infinitely many non-conjugate braids
Creators: name: Ito, Tetsuya
Publisher: name: arXiv
Year: 2019
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We show that if a link $L$ has a closed $n$-braid representative admitting non-degenerate exchange move, an exchange move that does not obviously preserve the conjugacy class, $L$ has infinitely many non-conjugate closed $n$-braid representatives.
description: 3 pages
Rogers-Ramanujan and the Baker-Gammel-Wills (Padé) conjecture
Creators: name: Lubinsky, Doron S.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: In 1961, Baker, Gammel and Wills conjectured that for functions $f$ meromorphic in the unit ball, a subsequence of its diagonal Padé approximants converges uniformly in compact subsets of the ball omitting poles of $f$. There is also apparently a cruder version of the conjecture due to Padé himself, going back to the earlier twentieth century. We show here that for carefully chosen $q$ on the unit circle, the Rogers-Ramanujan continued fraction $$1+\frac{qz|}{|1}+\frac{q^{2}z|}{|1}+\frac{q^{3}z|}{|1}+... $$ provides a counterexample to the conjecture. We also highlight some other interesting phenomena displayed by this fraction.
description: 43 pages published version
Speaking Stata: Paired, parallel, or profile plots for changes, correlations, and other comparisons
Creators: name: Cox, Nicholas J.
name: Cox, Nicholas J.
Publisher: name: Unknown
Year: 2009
Subjects: subject: Research Methods/ Statistical Methods
subject: profile plot
subject: parallel coordinates plot
subject: parallel line plot
subject: pair-link diagram
subject: bumps charts
subject: barometer charts
subject: graphics
subject: panel data
subject: longitudinal data
subject: arrows
subject: twoway

description: Paired, parallel, or profile plots showing the values of two variables may be constructed readily using a combination of graph twoway commands. This column explores the principles and practice of such plot-making, considering both wide and long (panel or longitudinal) data structures in which such data may appear. Applications include analysis of change over time or space and indeed any kind of correlation or comparison between variables. Such plots may be extended to show numeric values and associated name information.
Positive factorizations of pseudoperiodic homeomorphisms
Creators: name: Cuadrado, Pablo Portilla
Publisher: name: arXiv
Year: 2020
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We generalize a classical result concerning smooth germs of surfaces, by proving that monodromies on links of isolated complex surface singularities associated with reduced holomorphic map germs admit a positive factorization. As a consequence of this and a topological characterization of these monodromies by Anne Pichon, we conclude that a pseudoperiodic homeomorphism on an oriented surface with boundary with positive fractional Dehn twist coefficients and screw numbers, admits a positive factorization. We use the main theorem to give a sufficiency criterion for certain pseudoperiodic homeomorphisms with negative screw numbers to admit a positive factorization.
description: 33 pages, 1 figure. Much more detailed first sections that in previous section. Same content as in journal accepted version
Additional file 4 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista L.
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4: Supplemental Table 4. Risk of mortality associated with opioid utilization among adults initiating hemodialysis before and after 365 days, 2007–2014*.
The role of personality in social and economic choice: Data and variable description
Creators: name: Schmid, Basil
name: Engelmann, Jan B.
name: de Dreu, Carsten K.W.
name: Chumbley, Justin
name: Fehr, Ernst
Publisher: name: ETH Zurich
Year: 2020
Subjects: Codebook
List of variables
Trustgame
Experimental data
Self-reported personality questionnaires

description: How do fundamental concepts from economics, such as individuals’ preferences and beliefs, relate to equally fundamental concepts from psychology, such as relatively stable personality traits? Can personality traits help us better understand economic behavior across strategic contexts? The goal of this study is to investigate different personality profiles and examine the role of strategic context (the “situation”), personality traits (the “person”) and their interaction on beliefs and behaviors in different versions of extended trustgames (with and without the option to punish uncooperative behavior).
Cost utility analysis of tisagenlecleucel vs salvage chemotherapy in the treatment of relapsed/refractory diffuse large B-cell lymphoma from Singapore’s healthcare system perspective
Creators: name: Boon Piang Cher
name: Kar Yee Gan
name: Aziz, Mohamed Ismail Abdul
name: Lin, Liang
name: Hwang, William Ying Khee
name: Poon, Li Mei
name: Kwong Ng
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) have limited treatment options and poor prognoses. Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell therapy has shown early promise in improving survival outcomes, but at a high upfront cost. This study evaluated the cost-effectiveness of tisagenlecleucel versus salvage chemotherapy for treating patients with r/r DLBCL who have failed at least 2 lines of systemic therapies. A hybrid decision tree and three-state partitioned survival model (progression-free (PF), progressive disease and death) was developed from the Singapore healthcare payer perspective. Survival curves from JULIET trial and CORAL-1 extension study were extrapolated beyond trial period over a 15-year time horizon to estimate the underlying progression-free survival and overall survival parametric distributions for both arms. Health state utilities were retrieved from the literature, and direct costs were sourced from public healthcare institutions in Singapore. One-way probabilistic sensitivity analyses and scenario analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Compared with salvage chemotherapy, tisagenlecleucel was associated with a base-case incremental cost-effectiveness ratio (ICER) US$508,530 (S$686,516) per quality adjusted life year (QALY) gained and US$320,200 (S$432,269) per life year (LY) gained. One-way sensitivity analysis showed the ICER was most sensitive to time horizon, PF utility and cost of tisagenlecleucel. Scenario analyses confirmed that the ICERs remained high under favorable assumptions and substantial price reduction was required to reduce the ICER. Our analysis showed tisagenlecleucel use in r/r DLBCL patients who failed at least 2 prior lines of systemic therapies was associated with exceedingly high ICER, which is unlikely to represent good use of healthcare resources. Comparative clinical evidence from the ongoing trials might provide more insight into future evaluations.
Orientational orders of small anisotropic molecules confined in slit pores
Creators: name: Zhou, Xin
name: Chen, Hu
name: Iwamoto, Mitsumasa
Publisher: name: arXiv
Year: 2003
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We have studied phase behavior of hard gaussian overlap molecules with small anisotropic parameter confined in two plane parallel structureless hard walls. Our investigation based on standard constant-NPT Monte Carlo molecular simulation led us to some interesting findings. For small anisotropic molecules the nematic phase is instable in bulk, while, if the distance between the walls is small enough, an orientation-ordered phase can form. This result indicates that the required molecular elongation forming liquid-crystal phases is smaller in confinement than that in bulk. Considering the value of the elongation of molecules, the computed result inplies that small molecule liquid crystals may exist in confinement.
description: 5 pages, 7 figures
Additional file 1 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Supplemental Table 1. Methods for 1-year look back for claims data for comorbid conditions.
Additional file 3 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: Supplemental Table 3. Risk of mortality associated with opioid dose among adults on hemodialysis with ≥1 opioid prescriptions, 2007–2014* (N = 232,546).
Extreme anisotropy and gyrotropy of surface polaritons in Weyl semimetals
Creators: name: Chen, Qianfan
name: Erukhimova, Maria
name: Tokman, Mikhail
name: Belyanin, Alexey
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Weyl semimetals possess unique electrodynamic properties due to a combination of strongly anisotropic and gyrotropic bulk conductivity, surface conductivity, and surface dipole layer. We explore the potential of popular tip-enhanced optical spectroscopy techniques for studies of bulk and surface topological electron states in these materials. Anomalous dispersion, extreme anisotropy, and the optical Hall effect for surface polaritons launched by a nanotip provides information about Weyl node position and separation in the Brillouin zone, the value of the Fermi momentum, and the matrix elements of the optical transitions involving both bulk and surface electron states.
Vaso-occlusive crises and costs of sickle cell disease in patients with commercial, Medicaid, and Medicare insurance – the perspective of private and public payers
Creators: name: Nirmish R. Shah
name: Menaka Bhor
name: Latremouille-Viau, Dominick
name: Vikash Kumar Sharma
name: Puckrein, Gary A.
name: Gagnon-Sanschagrin, Patrick
name: Ankur Khare
name: Singh, Mukesh Kumar
name: Serra, Elizabeth
name: Mikhaïl Davidson
name: Liou Xu
name: Guerin, Annie
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: To characterize vaso-occlusive crises (VOCs) and describe healthcare costs among commercially-insured, Medicaid-insured, and Medicare-insured patients with sickle cell disease (SCD). The IBM Truven Health MarketScan Commercial (2000–2018), Medicaid Analytic eXtract (2008–2014), and Medicare Research Identifiable Files (2012–2016) databases were used to identify patients with ≥2 SCD diagnoses. Study measures were evaluated during a 12-month follow-up period, stratified by annual number of VOCs (i.e. 0, 1, and ≥2). Among 16,092 commercially-insured patients (mean age = 36.7 years), 35.3% had 1+ VOCs. Mean annual total all-cause healthcare costs were $15,747, $27,194, and $64,555 for patients with 0, 1, and 2+ VOCs, respectively. Total all-cause healthcare costs were mainly driven by inpatient (0 VOC = 31.0%, 1 VOC = 53.1%, 2+ VOCs = 65.4%) and SCD-related costs (0 VOC = 56.4%, 1 VOC = 78.4%, 2+ VOCs = 93.9%). Among 18,287 Medicaid-insured patients (mean age = 28.5 years, fee-for-service = 50.2%), 63.9% had 1+ VOCs. Mean annual total all-cause healthcare costs were $16,750, $29,880, and $64,566 for patients with 0, 1, and 2+ VOCs, respectively. Inpatient costs (0 VOC = 37.2%, 1 VOC = 64.3%, 2+ VOCs = 72.9%) and SCD-related costs (0 VOC = 60.9%, 1 VOC = 73.8%, 2+ VOCs = 92.2%) accounted for a significant proportion of total all-cause healthcare costs. Among 15,431 Medicare-insured patients (mean age = 48.2 years), 55.1% had 1+ VOCs. Mean annual total all-cause healthcare costs were $21,877, $29,250, and $58,308 for patients with 0, 1, and ≥2 VOCs, respectively. Total all-cause healthcare costs were mainly driven by inpatient (0 VOC = 47.9%, 1 VOC = 54.9%, 2+ VOCs = 67.5%) and SCD-related costs (0 VOC = 74.9%, 1 VOC = 84.4%, 2+ VOCs = 95.3%). VOCs managed at home were not captured. Analyses were descriptive in an observational setting; thus, no causal relationships can be inferred. A high proportion of patients experienced VOCs across payers. Furthermore, inpatient and SCD-related costs accounted for a significant proportion of total all-cause healthcare costs, which increased with VOC frequency.
Theory of four-wave mixing and accompanying dissociation and population transfer controlled with laser-induced continuum structures
Creators: name: Kimberg, V. V.
name: Popov, A. K.
name: George, Thomas F.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A theory is developed and applied to the study of opportunities and specific features of coherent control of four-wave mixing as well as of the accompanying processes in the continuous-wave regime, which involve transitions between bound and free quantum states. Such opportunities become feasible through constructive and destructive interference of quantum pathways. Two coupling schemes of practical importance are investigated. In the first, a ladder energy level scheme, fully-resonant sum-frequency nonlinear-optical generation of short-wavelength radiation driven by several strong fields is investigated. The relaxation processes as well as absorption of the fundamental and generated radiations, which play an important role, are taken into consideration. It is shown that the generation output can be considerably increased through the appropriate adjustment of several laser-induced continuum structures. In the second, a folded scheme, a possible control of two-photon dissociation (Lambda-scheme) using auxiliary laser radiation applied to the adjacent bound-free transition (V-configuration) is investigated. Besides dissociation, the proposed method enables one to control population transfer between two upper discreet levels via the lower-energy dissociation continuum, while direct transition between these states is not allowed. The opportunities of manipulating these processes as well as of four-wave-mixing-based spectroscopy are explored both analytically and through a numerical simulation for Na_2 dimers.
description: 39 pages, 18 figures, v.2 minor format changes
Additional file 2 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Supplemental Table 2. Opioids included in analysis.
Antioxidant capacity is repeatable across years but does not consistently correlate with a marker of peroxidation in a free-living passerine bird
Creators: name: Récapet, Charlotte
name: Arrivé, Mathilde
name: Doligez, Blandine
name: Bize, Pierre
Publisher: name: arXiv
Year: 2019
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Applications (stat.AP)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Oxidative stress occurs when reactive oxygen species (ROS) exceed antioxidant defences, which can have deleterious effects on cell function, health and survival. Therefore, organisms are expected to finely regulate pro-oxidant and antioxidant processes. ROS are mainly produced through aerobic metabolism and vary in response to changes in energetic requirements, whereas antioxidants may be enhanced, depleted or show no changes in response to changes in ROS levels. We investigated the repeatability, within-individual variation and correlation across different conditions of two plasmatic markers of the oxidative balance in 1108 samples from 635 free-living adult collared flycatchers (Ficedula albicollis). We sought to manipulate energy constraints by increasing wing load in 2012 and 2013 and by providing additional food in 2014. We then tested the relative importance of within- and between-individual variation on reactive oxygen metabolites (ROMs), a marker of lipid and protein peroxidation, and on non-enzymatic antioxidant defences (OXY test). We also investigated whether the experimental treatments modified the correlation between markers. Antioxidant defences were repeatable (range of repeatability estimates = 0.128--0.581), whereas ROMs were not (0--0.061). Antioxidants varied neither between incubation and nestling feeding nor between sexes. ROMs increased from incubation to nestling feeding in females and were higher in females than males. Antioxidant defences and ROM concentration were globally positively correlated, but the correlation varied between experimental conditions and between years. Hence, the management of oxidative balance in wild animals appears flexible under variable environmental conditions, an observation which should be confirmed over a wider range of markers.
Phase Structure of 2-Flavor Quark Matter: Heterogeneous Superconductors
Creators: name: Reddy, Sanjay
name: Rupak, Gautam
Publisher: name: arXiv
Year: 2004
Subjects: subject: Nuclear Theory (nucl-th)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the free energy of charge and color neutral 2-flavor quark matter within the BCS approximation. We consider both the homogeneous gapless superconducting phase and the heterogeneous mixed phase where normal and BCS superconducting phases coexist. We calculate the surface tension between normal and superconducting phases and use it to compare the free energies of the gapless and mixed phases. Our calculation, which retains only the leading order gradient contribution to the free energy, indicates that the mixed phase is energetically favored over an interesting range of densities of relevance to 2 flavor quark matter in neutron stars.
description: 11 pages, 4 figures. Major Revisions. Includes a detailed discussion of the kinetic terms of the effective theory, instabilities of the gapless phase and the charge neutral phase diagram
Pricing methods in outcome-based contracting: δ2: willingness-to-pay-based pricing
Creators: name: Nimer S. Alkhatib
name: Ramos, Kenneth
name: Erstad, Brian
name: Slack, Marion
name: McBride, Ali
name: Sandipan Bhattacharjee
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Plant Biology

description: Six Delta is a six-dimensional independent platform for outcome-based pricing/contracting. The second dimension (δ2) estimates prices on the basis of four willingness-to-pay (WTP) thresholds. We describe this dimension’s methodology and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib. Eight WTP scenarios based on four levels of real gross domestic product per capita (<1GDP/capita, 1 × GDP/capita, 3 × GDP/capita, and >3 × GDP/capita) and two market conditions (monopolistic versus competitive) were assumed. The incremental cost-utility ratio (ICUR) was applied to differently to both markets. In the monopolistic market, assuming no competitors, the cost/QALY ratio for a drug was used; whereas in the competitive market, assuming competitors, the incremental cost-utility ratio (ICUR) was applied. One-way sensitivity analyses were performed and predictive equations were specified to estimate the prices of treatment for the resulting eight WTP scenarios; for which subsequently the average and standard deviation were calculated. A gamma distribution was specified and Monte Carlo Simulation (MCS) was applied to estimate the dimension-specific price based on WTP (DSPWTP). A proof-of-concept exercise with osimertinib in NSCLC was performed for two hypothetical outcome-based contracts: 1-year (2019–2020) and 2-year (2019–2021). The 2018 wholesale acquisition cost (WAC) of $14,616 (30-day prescription) was used to estimate the DSPWTP for each contract. The 1-year estimates averaged $4,654 (SD=$6,462) and the MCS yielded a DSPWTP of $4,547 or −68.89% of the 2018 WAC for a 30-day prescription. The 2-year estimates averaged $4,7667 (SD=$6,480) with the MCS generating a DSPWTP of $4,704 or −67.82% of the WAC. We demonstrated that WTP-based methods that include various WTP thresholds and market conditions generate price estimates across these thresholds and market conditions that can be integrated into our proposed Six Delta platform for outcome-based pricing/contracting.
Amidation of deltacyclene and hexacyclic norbornadiene dimers with acetonitrile and water catalyzed by FeCl3·6H2O
Creators: name: Khusnutdinov, Ravil I.
name: Egorova, Tatyana M.
name: Rishat I. Aminov
name: Mayakova, Yulia Yu.
name: Mescheryakova, Ekaterina S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: FeCl3·6H2O-catalyzed Ritter amidation of deltacyclene and hexacyclic norbornadiene dimers containing both a double bond and a three-carbon ring in the molecule with acetonitrile and water was performed. Depending on the hydrocarbon structure, the reaction proceeds via C-C bond cleavage in the three-carbon ring or at the double bond to form the corresponding N-acetamides.
Amaurochrous magnus Barber & Sailer 1953
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Amaurochrous
Amaurochrous magnus

description: Amaurochrous magnus Barber & Sailer, 1953
 Distribution: United States: FL, GA (Barber & Bruner 1932), LA, MA (Hart 1919), VA (Van Duzee 1904).
 Comments: According to Barber & Sailer (1953), many of the early records of Amaurochrous dubius should be referred to this species. Hoffman (1971) gave the distribution for this species as “Southeastern United States, from Maryland to Louisiana ”; we have not found an authentic published record for Maryland.
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 47, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
Additional file 5 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista L.
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 5: Supplemental Table 5. Risk of mortality associated with opioid dose among adults with ≥1 claims for comorbid conditions of interest one year prior to hemodialysis initiation, 2007–2014* (N = 245,107).
A column of grains in the jamming limit: glassy dynamics in the compaction process
Creators: name: Luck, J. M.
name: Mehta, Anita
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate a stochastic model describing a column of grains in the jamming limit, in the presence of a low vibrational intensity. The key control parameter of the model, $ε$, is a representation of granular shape, related to the reduced void space. Regularity and irregularity in grain shapes, respectively corresponding to rational and irrational values of $ε$, are shown to be centrally important in determining the statics and dynamics of the compaction process.
description: 29 pages, 14 figures, 1 table. Various minor changes and updates. To appear in EPJ B