cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Roles of iPSC in Advancing Treatments for Neurological Disorders
Creators: name: Xinran Zhang
Publisher: name: Zenodo
Year: 2024

description: Historically, disease research in neuroscience faced limitations due to species barriers and constraints with human samples.The advent of iPSC-induced neurons represents a significant breakthrough for academic and pharmaceutical research.Interdisciplinary collaborations have played a pivotal role in advancing iPSC technology. These collaborations have yieldedinnovative technologies, enhanced our understanding of cellular interactions and expanded iPSC applications. Despiteprogress, challenges persist, including concerns about tumorigenicity, immune rejection, inherent heterogeneity, and difficultyin recapitulating sporadic diseases. Scalability issues and the absence of age-associated cellular features in iPSC models arenotable drawbacks. This concise review examines recent advancements in iPSC technology, focusing on its application inaddressing neurological diseases. It delves into iPSC integration in the pharmaceutical industry, emphasizing roles in diseasemodelling, drug discovery, and screening. Looking ahead, the exploration of innovative strategies, interdisciplinarycollaborations, and emerging technologies will continue shaping iPSC applications in neuroscience and the broaderbiomedical landscape. The systematic analysis and presentation of newly developed techniques in this review offer a roadmapfor overcoming obstacles, emphasizing the transformative impact of iPSC technology on academic research andpharmaceutical development, and providing new avenues for understanding, treating, and potentially curing neurologicaldiseases.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Lee Lai, Chin Chuck Lin, Mrs. Chin Chuck Lin, Jung Young, Mock Yet Wing, Chin Lin Sing, Young Him, Mah Ho, [Miss. Baplara Chee], [Miss. Nelon Chee], [Miss. Chew Luai Ing], Mr. Billy Chee, Miss. Billy Chee, [Miss. Vivian Abhee].
Cycloheximide can induce Bax/Bak dependent myeloid cell death independently of multiple BH3-only proteins
Creators: name: Goodall, KJ
name: Finch-Edmondson, ML
name: van Vuuren, J
name: Yeoh, GC
name: Gentle, IE
name: Vince, JE
name: Ekert, PG
name: Vaux, David
name: Callus, BA
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences

description: Apoptosis mediated by Bax or Bak is usually thought to be triggered by BH3-only members of the Bcl-2 protein family. BH3-only proteins can directly bind to and activate Bax or Bak, or indirectly activate them by binding to anti-apoptotic Bcl-2 family members, thereby relieving their inhibition of Bax and Bak. Here we describe a third way of activation of Bax/Bak dependent apoptosis that does not require triggering by multiple BH3-only proteins. In factor dependent myeloid (FDM) cell lines, cycloheximide induced apoptosis by a Bax/Bak dependent mechanism, because Bax-/- Bak-/- lines were profoundly resistant, whereas FDM lines lacking one or more genes for BH3-only proteins remained highly sensitive. Addition of cycloheximide led to the rapid loss of Mcl-1 but did not affect the expression of other Bcl-2 family proteins. In support of these findings, similar results were observed by treating FDM cells with the CDK inhibitor, roscovitine. Roscovitine reduced Mcl-1 abundance and caused Bax/Bak dependent cell death, yet FDM lines lacking one or more genes for BH3-only proteins remained highly sensitive. Therefore Bax/Bak dependent apoptosis can be regulated by the abundance of anti-apoptotic Bcl-2 family members such as Mcl-1, independently of several known BH3-only proteins.
The Impact of Board Environmental Expertise and Social Engagement on Firm Environmental Performance
Creators: name: Kim, Daehyun
name: J Marin, Michael
name: Richardson, Gordon
name: Salterio, Steven
name: Tsang, Albert
Publisher: name: University of Notre Dame
Year: 2025
Subjects: classificationCode: 41
subject: Environmental sciences

description: Corporate governance quality significantly impacts firm environmental performance. This study examines the effects of board environmental expertise (BEE), board social engagement (BSE), and traditional governance mechanisms (GOV) on sustainability. Analyzing 600 US-listed firms from 2010-2015, findings show that GOV, BEE, and BSE each positively affect environmental scores. Establishing a CSR committee and appointing a CSO further enhance sustainability, highlighting the role of board composition in improving environmental outcomes.
Le bayésianisme : une boussole épistémologique pour les sciences infirmières
Creators: name: Martin-Schreiber, Vincent
Publisher: name: Magazine de l'ACFAS
Year: 2024

description: Le bayésianisme représente une nouvelle façon de penser et de faire de la recherche en sciences infirmières. Cette approche, à la fois philosophique et statistique, permet de combiner des méthodes qualitatives et quantitatives pour mieux comprendre des phénomènes complexes en constante évolution. Dans le présent article, j’explique comment j’utilise le bayésianisme dans ma thèse de doctorat pour explorer la production du diagnostic du trouble de personnalité limite (TPL).

Article rédigé pour le magazine de l'ACFAS d'octobre 2024.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Pang Art, Pang Sen, Mr. Wong Nine, Mrs. Wong Nine, Chow Bing Sun, Lai Ching Sing, Pang Shue Kim, Low Poy, Lee Gim Wah, Lee Kuong Hoy, Chow Doy Joe, Wong Hee.
Draft genome sequence of Rhodococcus erythropolis NSX2, an actinobacterium isolated from a cadmium-contaminated environment
Creators: name: Egidi, E
name: Wood, Jennifer
name: Fox, EM
name: Liu, W
name: Franks, Ashley
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3105
subject: Genetics
classificationCode: 3107
subject: Microbiology

description: Rhodococcus erythropolis NSX2 is a rhizobacterium isolated from a heavy metal-contaminated environment. The 6.2-Mb annotated genome sequence shows that this strain harbors genes associated with heavy-metal resistance and xenobiotics degradation.
Genomewide association study of methane emissions in Angus beef cattle with validation in dairy cattle
Creators: name: Manzanilla-Pech, CIV
name: De Haas, Y
name: Hayes, BJ
name: Veerkamp, RF
name: Khansefid, Majid
name: Donoghue, KA
name: Arthur, PF
name: Pryce, Jennie
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3003
subject: Animal production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3105
subject: Genetics

description: Methane (CH4) is a product of enteric fermentation in ruminants, and it represents around 17% of global CH4 emissions. There has been substantial effort from the livestock scientific community toward tools that can help reduce this percentage. One approach is to select for lower emitting animals. To achieve this, accurate genetic parameters and identification of the genomic basis of CH4 traits are required. Therefore, the objectives of this study were 1) to perform a genomewide association study to identify SNP associated with several CH4 traits in Angus beef cattle (1,020 animals) and validate them in a lactating Holstein population (population 1 [POP1]; 205 animals); 2) to validate significant SNP for DMI and weight at test (WT) from a second Holstein population, from a previous study (population 2 [POP2]; 903 animals), in an Angus population; and 3) to evaluate 2 different residual CH4 traits and determine if the genes associated with CH4 also control residual CH4 traits. Phenotypes calculated for the genotyped Angus population included CH4 production (MeP), CH4 yield (MeY), CH4 intensity (MI), DMI, and WT. The Holstein population (POP1) was multiparous, with phenotypes on CH4 traits (MeP, MeY, and MI) plus genotypes. Additionally, 2 CH4 traits, residual genetic CH4 (RGM) and residual phenotypic CH4 (RPM), were calculated by adjusting MeP for DMI and WT. Estimated heritabilities in the Angus population were 0.30, 0.19, and 0.15 for MeP, RGM, and RPM, respectively, and genetic correlations of MeP with DMI and WT were 0.83 and 0.80, respectively. Estimated heritabilities in Holstein POP1 were 0.23, 0.30, and 0.42 for MeP, MeY, and MI, respectively. Strong associations with MeP were found on chromosomes 4, 12, 14, 20, and 30 at P < 0.001, and those chromosomes also had significant SNP for DMI in Holstein POP1. In the Angus population, the number of significant SNP for MeP at P < 0.005 was 3,304, and approximately 630 of those SNP also were important for DMI and WT. When a set (approximately 3,300) of significant SNP for DMI and WT in the Angus population was used to estimate genetic parameters for MeP and MeY in Holstein POP1, the genetic variance and, consequently, the heritability slightly increased, meaning that most of the genetic variation is largely captured by these SNP. Residual traits could be a good option to include in the breeding goal, as this would facilitate selection for lower emitting animals without compromising DMI and WT.
Genomewide association study of methane emissions in Angus beef cattle with validation in dairy cattle
Creators: name: Manzanilla-Pech, CIV
name: De Haas, Y
name: Hayes, BJ
name: Veerkamp, RF
name: Khansefid, M
name: Donoghue, KA
name: Arthur, PF
name: Pryce, Jennie
Publisher: name: La Trobe
Year: 2023

description: Methane (CH4) is a product of enteric fermentation in ruminants, and it represents around 17% of global CH4 emissions. There has been substantial effort from the livestock scientific community toward tools that can help reduce this percentage. One approach is to select for lower emitting animals. To achieve this, accurate genetic parameters and identification of the genomic basis of CH4 traits are required. Therefore, the objectives of this study were 1) to perform a genomewide association study to identify SNP associated with several CH4 traits in Angus beef cattle (1,020 animals) and validate them in a lactating Holstein population (population 1 [POP1]; 205 animals); 2) to validate significant SNP for DMI and weight at test (WT) from a second Holstein population, from a previous study (population 2 [POP2]; 903 animals), in an Angus population; and 3) to evaluate 2 different residual CH4 traits and determine if the genes associated with CH4 also control residual CH4 traits. Phenotypes calculated for the genotyped Angus population included CH4 production (MeP), CH4 yield (MeY), CH4 intensity (MI), DMI, and WT. The Holstein population (POP1) was multiparous, with phenotypes on CH4 traits (MeP, MeY, and MI) plus genotypes. Additionally, 2 CH4 traits, residual genetic CH4 (RGM) and residual phenotypic CH4 (RPM), were calculated by adjusting MeP for DMI and WT. Estimated heritabilities in the Angus population were 0.30, 0.19, and 0.15 for MeP, RGM, and RPM, respectively, and genetic correlations of MeP with DMI and WT were 0.83 and 0.80, respectively. Estimated heritabilities in Holstein POP1 were 0.23, 0.30, and 0.42 for MeP, MeY, and MI, respectively. Strong associations with MeP were found on chromosomes 4, 12, 14, 20, and 30 at P < 0.001, and those chromosomes also had significant SNP for DMI in Holstein POP1. In the Angus population, the number of significant SNP for MeP at P < 0.005 was 3,304, and approximately 630 of those SNP also were important for DMI and WT. When a set (approximately 3,300) of significant SNP for DMI and WT in the Angus population was used to estimate genetic parameters for MeP and MeY in Holstein POP1, the genetic variance and, consequently, the heritability slightly increased, meaning that most of the genetic variation is largely captured by these SNP. Residual traits could be a good option to include in the breeding goal, as this would facilitate selection for lower emitting animals without compromising DMI and WT.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Chow Mon Bew, Lee Leong Yee, Lee Mew Kum, Wong Shee Leong, Gilbert Leong, Hing Leong, Charlie Leong, Anne Leong, Lum Chew, [Chong Yet Hoo], [Wong Lum], [Lew Hon Jeong], Ng June.
Dodecosis saperdina Bates 1867
Creators: name: Santos-Silva, Antonio
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Dodecosis
Dodecosis saperdina

description: Dodecosis saperdina Bates, 1867
(Fig. 19)
Dodecosis saperdina Bates, 1867: 27.
Remarks. – This species was described based on a single specimen from Brazil (Pará). Currently it is known from French Guiana and Brazil (Amapá, Amazonas, Pará, Rondônia, Mato Grosso) (Monné 2023a; Tavakilian & Chevillotte 2022).
Material examined. – BRAZIL, Acre (new state record): Senador Guiomard, 1 ♀, no date and collector indicated (MZSP 52520).
description: Published as part of Santos-Silva, Antonio, 2023, Description of a new species of Piriana Santos-Silva, Galileo & McClarin, and notes and new records in Cerambycinae and Lamiinae from the Neotropical Region (Coleoptera, Cerambycidae), pp. 1-12 in Faunitaxys 11 (12) on page 2, DOI: 10.57800/faunitaxys-11(12), http://zenodo.org/record/15365763
Does walking after lumbar spinal surgery predict recovery of function at six months? Protocol for a prospective cohort study
Creators: name: Gilmore, Sarah
name: McClelland, Jodie
name: Davidson, Megan
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Background: Physiotherapists are commonly involved in the management of patients immediately following lumbar spinal surgery. There is however, very little research to guide physiotherapy intervention in the acute post-operative period, and the advice provided to patients regarding post-operative walking and physical activity has been shown to be highly variable. The primary aim of this research is to establish whether the amount of walking patients perform in the week following lumbar spinal surgery predicts improvement in function at 6 months. Methods: This study will be a prospective cohort study design, with a projected sample size of 250 participants. Patients undergoing surgery for the management of a disc prolapse, degenerative disc disease, lumbar spinal stenosis and/or degenerative spondylolysthesis will be invited to participate in this study. Outcome measurement will take place pre-operatively and at six months post-operatively. The primary outcome variable will be self-reported function, measured using the Modified Oswestry Disability Questionnaire and the physical component summary of the SF-36. Each participant will be fitted with an activPAL3 accelerometer to be worn for the first seven post-operative days. This accelerometer will record time spent in active versus sedentary postures, step count and time spent walking. Multivariable logistic regression analysis will be used to investigate the relationship between the total time spent walking over the first seven post-operative days, and outcome at six months. Discussion: The results from this research will help to guide patient management during the inpatient phase, by identifying patients who are at risk of poorer outcome due to limited walking time. These patients may benefit from ongoing rehabilitation and outpatient physiotherapy services. This information will also provide a foundation for further research into interventions designed to optimise post-operative activity.
Nuclear physics in proton therapy: new approaches for proton beam range verification using delayed gamma-rays
Creators: name: Bäcker, Claus Maximilian
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Proton therapy
subject: Range verification
subject: Radio-activation
subject: Cross section
subject: Nuclear reaction
subject: Gamma-ray spectrometry
subject: Positron emission tomography
subject: 530
subject: Protonentherapie
subject: Strahlentherapie
subject: Gammaspektroskopie

description: In-vivo monitoring of the delivered dose is desirable in radiation therapy. Radionuclides generated during the proton irradiation can be used for imaging methods from nuclear medicine after the treatment session. In order to improve these techniques, this work focuses on three different aspects of nuclear physics from basic nuclear physics measurements to a clinical validation. The most relevant nuclear interaction is the production of C-11 from carbon as this nuclear interaction is used as a monitor reaction for the measurement of several other radionuclides. Furthermore, this is one of the relevant residuals produced from the tissue nuclei. As the data from the literature scatter by about 15%, a new reference cross section value of (68 ± 3) mb at 97 MeV is determined from the cross sections measured in different settings. In a second part, the activation of iodine during proton irradiation is investigated. Several radionuclides are produced from iodine which decay by the emission of positrons and can potentially be used for PET imaging subsequent to the fractional treatment. In the last step, the activation of titanium implants is investigated. A benchmarking test including MC simulations is performed which study reveals the limited applicability of PET imaging with implants for field verification in proton therapy.
description: Die Überwachung der applizierten Dosisverteilung in der Strahlentherapie kann zur Optimierung der Therapie genutzt werden. Während der Protonenbestrahlung erzeugte Radionuklide können nach der Behandlungssitzung zur Bildgebung mit Methoden aus der Nuklearmedizin verwendet werden. Die vorliegende Arbeit untersucht drei verschiedene kernphysikalische Aspekte von der Untersuchung von Kernreaktionen hin zu einer klinischen Validierung, um diese Techniken zu verbessern. Zunächst wird die Produktion von C-11 aus Kohlenstoff untersucht, da diese Reaktion in der Kernphysik als Monitorreaktion verwendet wird. Die Literaturwerte der Wirkungsquerschnitte variieren um bis zu 15%. Außerdem stellt diese Reaktion eine wichtige Produktion von Radionukliden in menschlichem Gewebe dar. Als neuer Referenzwert kann (68 ± 3) mb bei einer Energie von 97 MeV bestimmt werden. In einem weiteren Schritt wird die Aktivierung von Iod untersucht. Da viele Positronenemitter bei der Bestrahlung von Iod produziert werden, kann die Aktivierung von Iod zur PET Bildgebung verwendet werden. Als letztes wird die Aktivierung von Titanimplantaten betrachtet. Dazu wird dazu ein Sensitivitätstest inklusive der Aktivitätsvorhersage durchgeführt, der die beschränkten Einsatzmöglichkeiten der PET Bildgebung zur Feldverifikation in der Protonentherapie aufzeigt.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket Stubs for the following passengers: Yee Dan, Chong W[] Woo, Eng Yee Hong, Lee Hon, Lee Sing Jung, Chow Git Jung, Low Yee Bun, Lim Chew, Chee Yat Kew, Soo Yee Gong.
Systems analysis identifies miR-29b regulation of invasiveness in melanoma
Creators: name: Andrews, Miles
name: Cursons, J
name: Hurley, DG
name: Anaka, M
name: Cebon, Jonathan
name: Behren, Andreas
name: Crampin, EJ
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Background: In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing regulated changes across large sets of genes. The miR-target databases TargetScan and DIANA-microT predict putative relationships by examining sequence complementarity between miRs and mRNAs. However, it remains a challenge to identify which miR-mRNA interactions are active at endogenous expression levels, and of biological consequence. Methods: We developed a workflow to integrate TargetScan and DIANA-microT predictions into the analysis of data-driven associations calculated from transcript abundance (RNASeq) data, specifically the mutual information and Pearson's correlation metrics. We use this workflow to identify putative relationships of miR-mediated mRNA repression with strong support from both lines of evidence. Applying this approach systematically to a large, published collection of unique melanoma cell lines - the Ludwig Melbourne melanoma (LM-MEL) cell line panel - we identified putative miR-mRNA interactions that may contribute to invasiveness. This guided the selection of interactions of interest for further in vitro validation studies. Results: Several miR-mRNA regulatory relationships supported by TargetScan and DIANA-microT demonstrated differential activity across cell lines of varying matrigel invasiveness. Strong negative statistical associations for these putative regulatory relationships were consistent with target mRNA inhibition by the miR, and suggest that differential activity of such miR-mRNA relationships contribute to differences in melanoma invasiveness. Many of these relationships were reflected across the skin cutaneous melanoma TCGA dataset, indicating that these observations also show graded activity across clinical samples. Several of these miRs are implicated in cancer progression (miR-211, -340, -125b, -221, and -29b). The specific role for miR-29b-3p in melanoma has not been well studied. We experimentally validated the predicted miR-29b-3p regulation of LAMC1 and PPIC and LASP1, and show that dysregulation of miR-29b-3p or these mRNA targets can influence cellular invasiveness in vitro. Conclusions: This analytic strategy provides a comprehensive, systems-level approach to identify miR-mRNA regulation in high-throughput cancer data, identifies novel putative interactions with functional phenotypic relevance, and can be used to direct experimental resources for subsequent experimental validation.
Σακχαρώδης διαβήτης τύπου 1 και ποιότητα ζωής: βιβλιογραφική ανασκόπηση
Creators: name: Καραγεώργου, Βασιλική
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Σακχαρώδης διαβήτης
subject: Ποιότητα ζωής
subject: Χρόνιες ασθένειες -- Ψυχολογικές απόψεις
subject: Χρόνιες ασθένειες -- Κοινωνικές απόψεις
subject: Ποιότητα ζωής
subject: Σακχαρώδης διαβήτης τύπου 1
subject: Quality of life
subject: Type 1 diabetes

description: Αριθμός Εισαγωγής: 013313 cd
description: Η παρούσα βιβλιογραφική ανασκόπηση εξετάζει την ποιότητα ζωής των ατόμων που ζουν με σακχαρώδη Διαβήτη Τύπου 1. Ο διαβήτης αποτελεί μία πολύ-παραγοντική χρόνια πάθηση η οποία επιδρά αρνητικά σε πολυάριθμους τομείς της καθημερινής ζωής των ασθενών. Στην παρούσα κλινική πρακτική, ο διαβήτης Τύπου 1 αποτελεί ένα σύνθετο φαινόμενο με ποικίλες κλίμακες μετρήσεων της ποιότητας ζωής (QOL) των ασθενών και διαφορετικά μέσα και μεθόδους προσέγγισης για την πιο αποτελεσματική διαχείρισή του. Ο σκοπός της συγκεκριμένης έρευνας είναι να τοποθετηθεί περεταίρω το ζήτημα της ποιότητας ζωής των ασθενών και να ενημερωθεί η βιβλιογραφία σχετικά με τις κλίμακες ποιότητας και τους παράγοντες που την επηρεάζουν. Η έρευνα πραγματοποιήθηκε με τη μέθοδο αναζήτησης και ανασκόπησης πηγών με σκοπό την αποσαφήνιση του όρου ποιότητας ζωής των ατόμων με διαβήτη και των παραγόντων επίδρασης του. Συνολικά, πέντε διαφορετικές βάσεις δεδομένων χρησιμοποιήθηκαν για την παρούσα ανασκόπηση, τα MEDLINE, PubMed, OVID,Embase , CINAHL και PsycINFO. Οι προαναφερθείσες βάσεις δεδομένων αναζητήθηκαν για έγκυρες επιστημονικές πηγές σχετικά με τα ερευνητικά ερωτήματα της παρούσας βιβλιογραφικής ανασκόπησης. Η ανάλυση των πηγών προσέφερε πληροφορίες όσων αφορά τις στρατηγικές ιατρικής διαχείρισης, της ποιότητας υγείας των ασθενών (HQOL), την αναγνώριση έξι διαφορετικών κλιμάκων μέτρησης της ποιότητας ζωής και τους βιολογικούς και ψυχοκοινωνικούς παράγοντες που αποτελούν τροχοπέδη στην λειτουργικότητα των ασθενών. Κύρια συμπεράσματα της ανασκόπησης αφορούν την ανάγκη για αυτοπαρακολούθηση και άμεση αντιμετώπιση του ασθενούς σχετικά με τα επίπεδα υπογλυκαιμίας, καθώς και οι σοβαρές χρόνιες επιπλοκές, το γυναικείο φύλο, η μικρότερη εκπαίδευση, η διάρκεια της νόσου, αποτελούν παράγοντες κινδύνου, με, αναγνωρισμένα, χειρότερη ποιότητα ζωής. Η συμβολή της έρευνας αποσκοπεί στην ενδελεχή κατανόηση του ζητήματος και στην ανάγκη για ανάπτυξη κατάλληλων στρατηγικών και μετρήσεων στη διαχείριση του διαβήτη Τύπου 1.
title: Isaac Broome: Ott and Brewer’s Ceramic Artist
Creators: name: Randolph, Molly
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Ott and Brewer
subject: Isaac Broome
subject: Philadelphia Centennial
subject: Baseball Vase
subject: New Jersey Ceramics
subject: John Hart Brewer

description: American ceramics created before the Centennial celebration of 1876 were largely unsophisticated and liberally copied the ceramic manufacturers of Europe. The American public yearned for European-made goods because potteries in the United States had the reputation of crafting crude unsophisticated wares not fit for American dining tables. Ceramic makers saw the Centennial as an opportunity to change the minds of the American public and the rest of the world; they wished to show the creative force and the skill that could be found in American ceramic firms. In preparation for the Centennial many firms, like Ott and Brewer, hired talented artists to design the company’s display. Isaac Broome, a marble sculptor educated at the Pennsylvania Academy of Fine Arts was the perfect person to achieve this. This paper argues that the Centennial encouraged American makers to step out from behind the shadow of European achievements. American potters wished to impress at the Centennial not only for national pride, but to provide themselves with economic opportunities imperative to their success. Isaac Broome was essential to not only the success of Ott and Brewer’s exhibition display, but also in helping to plant the seeds of change that would blossom into a thriving industry. He did this by positioning his country as the inheritor of a Western tradition, as the next step in the progression of European art. In his display, American subjects became high art, their imagery merged with old tropes to create a hybrid of concepts that an American audience would find affirming, and thus encourage them to buy American. Broome was successful and his pieces caught the attention of a national and international audience. The American ceramic industry, over the last quarter of the nineteenth century would thrive and grow.
Me mamm, laret dein me
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
What Is Necessary For Effective Eu Leadership That Can Promote (Inter) Regionalism In Science And Cultural Diplomacy With The South?
Creators: name: Amaya, Ana B.
name: Kingah, Stephen
Publisher: name: Zenodo
Year: 2016
Subjects: Science Diplomacy
Cultural Diplomacy
Regionalism
Interregionalism
European Union

description: The European Union (EU) has cooperated with other regions of the South since its inception. While trade and the provision of development aid have been highly visible, there is also a long tradition of exchanges in science and cultural diplomacy (SCD), either as a union or via its member states.

However, beyond recognizing that these types of diplomacy are taking place, how can we measure the extent of its effectiveness in fostering regional integration or regionalism? This blog note introduces a framework to assess the performance of regional organizations and in comparative analysis between regions.
Antibody-Drug Conjugates for Cancer Therapy
Creators: name: Parslow, Adam
name: Parakh, Sagun
name: Lee, Fook-Thean
name: Gan, Hui
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences
classificationCode: 3404
subject: Medicinal and biomolecular chemistry

description: Antibody-drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell. The development of these compounds provides exciting opportunities for improvements in patient care. Here, we review the key issues impacting on the clinical success of ADCs in cancer therapy. Like many other developing therapeutic classes, there remain challenges in the design and optimisation of these compounds. As the clinical applications for ADCs continue to expand, key strategies to improve patient outcomes include better patient selection for treatment and the identification of mechanisms of therapy resistance.
Imprints of Climate Signals in a 204 Year δ18O Tree-Ring Record of Nothofagus pumilio From Perito Moreno Glacier, Southern Patagonia (50°S)
Creators: name: Grießinger, Jussi
name: Langhamer, Lukas
name: Schneider, Christoph
name: Saß, Björn L.
name: Steger, David N.
name: Skvarca, Pedro
name: Braun, Matthias H.
name: Meier, Wolfgang
name: Srur, Ana M.
name: Hochreuther, Philipp
Publisher: name: Humboldt-Universität zu Berlin
Year: 2018
Subjects: subject: tree-ring δ18O
subject: Nothofagus pumilio
subject: Southern Patagonia
subject: Perito Moreno Glacier
subject: Southern Annular Mode (SAM)
subject: backward trajectory modeling
subject: main weather types
subject: 550 Geowissenschaften

description: A 204 year-long record of δ18O in tree-ring cellulose of southern beech (Nothofagus pumilio) from a site near Perito Moreno Glacier (50°S) in Southern Patagonia was established to assess its potential for a climate reconstruction. The annually resolved oxygen isotope chronology is built out of seven individual tree-ring δ18O series with a significant mean inter-series correlation (r = 0.61) and is the first of its kind located in Southern America south of 50°S. Over a common period from 1960 to 2013 of available stationary and high-resolution gridded CRU TS v. 4.01 data, the δ18O chronology exhibits a strong sensitivity toward hydroclimatic as well as temperature parameters as revealed by correlation analyses. Among these, positive correlations with maximum temperature in the first part of the summer season (CRU rONDJ = 0.51, p < 0.01) and negative correlations with precipitation in the latter half of the vegetation period (CRU rONDJ = −0.54, p < 0.01) show the highest sensitivities. A strong supra-regional influence of the Southern Annular Mode (SAM) is clearly recorded in this chronology as indicated by significant positive correlations during the vegetation period (rONDJ = 0.62, p < 0.01). This indicates that the presented δ18O-chronology shows great promise to reconstruct the influence and variability of the SAM within the last two centuries in southern South America. The modulation of positive and negative anomalies within this series can be interlinked to changes in moisture source origin as revealed by backward trajectory modeling. Additionally, these anomalies can be directly associated to positive or negative phases of the Antarctic Oscillation Index (AAOI) and therefore the strength of the Westerlies. Aligned by the analysis on the influence of different main weather types on the δ18O chronology it is shown that such time-series hold the potential to additionally capture their respective influence and change during the last centuries.
title: Paper: "Universal Priors to Science: How the Liberal Arts Could Revitalize Science," October, 1988
Creators: name: Warfield, John
Publisher: name: George Mason University
Year: 1988
Subjects: subject: Warfield, John N.
subject: Universal Priors to Science
subject: Liberal Arts

description: Manuscript: typescript, 21 pgs. 8.5" x 11" (21.6 cm x 29.7 cm)
description: In this paper Warfield postulates that there are four Universal Priors to Science: the human being, language, reasoning through relationships, and archival representation. Warfield believes that these are areas that fall under the study of the liberal arts and humanities (in partnership with the social sciences and mathematics). Therefore, the liberal arts has the potential to revitalize science. John N. Warfield Collection 24.2
Paradigmatic Sociology: Fulfilling the Vision of Auguste Comte
Creators: name: Bernard Phillips
Publisher: name: Zenodo
Year: 2024
Subjects: Individual, paradigm, evolution, bureaucracy, interdisciplinary, perception, way of life.

description: Abstract: There are five parts of this paper: (1) Introduction. Here I focus on my overarching goal of moving toward fulfilling Auguste Comte’s goal of a paradigmatic sociological approach to solving personal and world problems. I introduce the work of Jonathan Turner, Thomas Kuhn, C. Wright Mills and Alvin W. Gouldner to illustrate the importance of an orientation that yields a contrast between a bureaucratic and an interactive and evolutionary way of life. (2) Turner’s Law of Positive Emotional Energy. It is here that we learn to “accentuate the positive,” as the song goes, by making use of two powerful procedures for personal development: EVOLUTIONARY PERCEPTION and the EAST-WEST STRATEGY. These yield increasing self-confidence, resulting in an improving self-image, pointing the individual in an evolutionary direction. Central to this approach is the idea that the further development of the individual is the basis for the continued evolution of society. (3) Turner’s Law of Negative Emotional Energy. We learn here to “eliminate the negative” and find personal satisfaction in doing so. We must take into account the immense power of our bureaucratic way of life in influencing us negatively—with its focus on hierarchy, narrow specialization and personal conformity—from the very moment of our birth. Yet once again the processes of EVOLUTIONARY PERCEPTION and the EAST-WEST STRATEGY can come to our rescue. We must realize that those procedures must become habitual if they are to be effective against the full power of our present way of life. Equally, we must understand that paradigmatic sociologists must realize that their own extraordinarily important role is to demonstrate the power of these ideas in their own personal behavior. (4) An Image of the Future. I follow the mantra of Confucius: “It is man that makes the Way great, and not the Way that makes man great.”  Lawrence Busch and Fred Polak developed an image that includes the continuing evolution of ever more individuals throughout society with respect to “head,” “heart” and “hand.” Far beyond the solution of society’s solution of its mammoth problems, we might anticipate future developments beyond our wildest dreams. (5) Resume. It is essential to establish my credibility for this far-reaching paper and, as well, to present the range of my academic experiences that enabled me to emerge with throughout my academic lifetime to emerge with these ideas.
Main document journal of vascular disease IRS
Creators: name: NOURELDIN, MOHAMED MOHAMED AHMED
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 320226
subject: Surgery

description: Comparative study between mechanical rotational atherectomy combined with drug coated balloon versus drug coated balloon alone for treatment of in-stent restenosis during peripheral endovascular interventions. A multicentric trial
Ozineus elongatus Bates 1863
Creators: name: Santos-Silva, Antonio
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Ozineus
Ozineus elongatus

description: Ozineus elongatus Bates, 1863
(Fig. 17)
Ozineus elongatus Bates, 1863: 278.
Remarks. – This species was described based on a single specimen from Brazil (Amazonas, Tefé). It is currently the only species of the genus (Monné et al. 2020) and is known from Panama, French Guiana, and Brazil (Amazonas, Pará, Rondônia) (Monné 2023b; Tavakilian & Chevillotte 2022).
Material examined. – BRAZIL, Acre (new state record): Bujari, FES Antimary, 9º20’01”S 68º19’17”W, 1 ♂, 21.X-4.XI.2016, E.F. Morato & J.A. Rafael leg. (MZSP 52517).
description: Published as part of Santos-Silva, Antonio, 2023, Description of a new species of Piriana Santos-Silva, Galileo & McClarin, and notes and new records in Cerambycinae and Lamiinae from the Neotropical Region (Coleoptera, Cerambycidae), pp. 1-12 in Faunitaxys 11 (12) on page 2, DOI: 10.57800/faunitaxys-11(12), http://zenodo.org/record/15365763
The Agreement between Parent-Reported and Directly Measured Child Language and Parenting Behaviors
Creators: name: Bennetts, Shannon
name: Mensah, FK
name: Westrupp, Elizabeth
name: Hackworth, Naomi
name: Reilly, S
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5204
subject: Cognitive and computational psychology

description: Parenting behaviors are commonly targeted in early interventions to improve children's language development. Accurate measurement of both parenting behaviors and children's language outcomes is thus crucial for sensitive assessment of intervention outcomes. To date, only a small number of studies have compared parent-reported and directly measured behaviors, and these have been hampered by small sample sizes and inaccurate statistical techniques, such as correlations. The Bland-Altman Method and Reduced Major Axis regression represent more reliable alternatives because they allow us to quantify fixed and proportional bias between measures. In this study, we draw on data from two Australian early childhood cohorts (N = 201 parents and slow-to-talk toddlers aged 24 months; and N = 218 parents and children aged 6-36 months experiencing social adversity) to (1) examine agreement and quantify bias between parent-reported and direct measures, and (2) to determine socio-demographic predictors of the differences between parent-reported and direct measures. Measures of child language and parenting behaviors were collected from parents and their children. Our findings support the utility of the Bland-Altman Method and Reduced Major Axis regression in comparing measurement methods. Results indicated stronger agreement between parent-reported and directly measured child language, and poorer agreement between measures of parenting behaviors. Child age was associated with difference scores for child language; however, the direction varied for each cohort. Parents who rated their child's temperament as more difficult tended to report lower language scores on the parent questionnaire, compared to the directly measured scores. Older parents tended to report lower parenting responsiveness on the parent questionnaire, compared to directly measured scores. Finally, speaking a language other than English was associated with less responsive parenting behaviors on the videotaped observation compared to the parent questionnaire. Variation in patterns of agreement across the distribution of scores highlighted the importance of assessing agreement comprehensively, providing strong evidence that simple correlations are grossly insufficient for method comparisons. We discuss implications for researchers and clinicians, including guidance for measurement selection, and the potential to reduce financial and time-related expenses and improve data quality. Further research is required to determine whether findings described here are reflected in more representative populations.
title: Racial/Ethnic Differences in Infant Mortality: Evidence from North Carolina
Creators: name: Kitsantas, Panagiota
name: Gaffney, Kathleen
Publisher: name: George Mason University
Year: 2010
Subjects: subject: Infant mortality
subject: North carolina
subject: Race
subject: Infant death

description: Poster created for presentation
description: Racial/ethnic disparities in infant mortality constitute a critical public health problem. North Carolina (NC) ranks 45th in teh US, with 8.5 infant deaths per 1,000 life births compared to the current US rate of 6.6 per 1,000 live births. Among minorities in NC, the rate is even higher 13.9 per live births
The de.NBI Training Network
Creators: name: Grüning, Björn
name: Training, The De.NBI Special Interest Group
Publisher: name: F1000Research
Year: 2016

description: The de.NBI network is an academic funding initiative of the German Ministry of Education and Research and (BMBF), started in March 2015. The consortium consists of 23 project partners organised in eight service centers and one central administration and coordination unit. The centers form a distributed infrastructure.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Lee Ying Loy, Chow Loy, Seto Jun, Lee Bark Wei, Lee Shong Ho, Yick Sam Yuen, Lee Soo Gim, Jung Bow Sam, Lee Jone Jin, [Der Wing Quan].
Recent Climatic Mass Balance of the Schiaparelli Glacier at the Monte Sarmiento Massif and Reconstruction of Little Ice Age Climate by Simulating Steady-State Glacier Conditions
Creators: name: Weidemann, Stephanie Suzanne
name: Arigony-Neto, Jorge
name: Jaña, Ricardo
name: Netto, Guilherme
name: Gonzalez, Inti
name: Casassa, Gino
name: Schneider, Christoph
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Monte Sarmiento Massif
subject: Schiaparelli Glacier
subject: glacier climatic mass balance
subject: glacier surface energy and mass balance model
subject: Little Ice Age
subject: 550 Geowissenschaften

description: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: The Cordillera Darwin Icefield loses mass at a similar rate as the Northern and Southern Patagonian Icefields, showing contrasting individual glacier responses, particularly between the north-facing and south-facing glaciers, which are subject to changing climate conditions. Detailed investigations of climatic mass balance processes on recent glacier behavior are not available for glaciers of the Cordillera Darwin Icefield and surrounding icefields. We therefore applied the coupled snow and ice energy and mass balance model in Python (COSIPY) to assess recent surface energy and mass balance variability for the Schiaparelli Glacier at the Monte Sarmiento Massif. We further used COSIPY to simulate steady-state glacier conditions during the Little Ice Age using information of moraine systems and glacier areal extent. The model is driven by downscaled 6-hourly atmospheric data and high resolution precipitation fields, obtained by using an analytical orographic precipitation model. Precipitation and air temperature offsets to present-day climate were considered to reconstruct climatic conditions during the Little Ice Age. A glacier-wide mean annual climatic mass balance of −1.8 ± 0.36 m w.e. a −1 was simulated between between April 2000 and March 2017. An air temperature decrease between −0.9 ° C and −1.7 ° C in combination with a precipitation offset of up to +60% to recent climate conditions is necessary to simulate steady-state conditions for Schiaparelli Glacier in 1870.
The measurement of media literacy in eating disorder risk factor research: psychometric properties of six measures
Creators: name: McLean, Sian
name: Paxton, Susan
name: Wertheim, Eleanor
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 520108
subject: Testing, assessment and psychometrics
classificationCode: 5203
subject: Clinical and health psychology

description: Background: Evaluation of media literacy-based interventions for the prevention of eating disorder risk is limited by the lack of appropriate measures with established psychometric properties with which to assess change in media literacy. This study aims to fill this gap by examining the psychometric properties and use in eating disorders risk factor research of six measures of media literacy that assess media processing and critical thinking about general media and critical thinking about appearance-focused media. Methods: The factor structure, internal consistency, test-retest reliability, and construct validity, including convergent and discriminant validity, were examined in six measures in two samples of early adolescent females. The measures were the Realism Scepticism, Similarity Scepticism, and Desirability Scepticism subscales of the Media Attitudes Questionnaire, the Fake subscale of the Critical Processing of Beauty Images Scale, the Critical Thinking about Media Messages scale, and Critical Thinking about Media Messages - Appearance Focus scale. Results: The factor structure of the measures was supported with factor analysis. Items from the Media Attitudes Questionnaire loaded on the three subscales Realism Scepticism, Similarity Scepticism, and Desirability Scepticism and items from each of the Fake subscale, Critical Thinking about Media Messages scale and Critical Thinking about Media Messages - Appearance Focus scale loaded on one scale. In addition, scores on the measures were reliable (adequate internal consistency and test-retest reliability) and valid (adequate construct, convergent, and discriminant validity) in early adolescent females. Two exceptions were Realism Scepticism, which had slightly low test-retest reliability, and the Fake subscale, for which support for construct validity was lacking. Conclusions: This study provides evidence to support the use of select media literacy measures, particularly the Realism Scepticism subscale and the Critical Thinking about Media Messages scale, in eating disorder risk factor research and the findings will contribute to enhanced evaluation of media literacy-based prevention interventions.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket Stubs for the following passengers: Law Kee Chong, Chan Yee Ward, Mah Ting Fon, Wong Suey, Joe Yee, Chow Su[n] Jok, Wong Pon Lan, Wong Hong Hing, Wong Wing Chew, Lee Let.
Supplementary document for Optical nanoimaging of highly-confined phonon polaritons in atomically-thin nanoribbons of α-MoO₃ - 6419473.pdf
Creators: name: Zeng, Ying
name: Sun, Tian
name: Chen, Runkun
name: Ma, Weiliang
name: Yan, Qizhi
name: lu, dunzhu
name: Qin, Tianwei
name: Hu, Caixing
name: Yang, Xiaosheng
name: li, peining
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Numerical simulation and supplemental experiment results