cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
D4.4 – PALOMERA 2nd Policy Brief
Creators: name: Stern, Niels
name: Gouzi, Françoise
name: Stone, Graham
name: Rooryck, Johan
name: Dreyer, Malte
name: Laakso, Mikael
name: Da Silva Ferreira, Nelson Henrique
name: Rabar, Ursula
name: Proudman, Vanessa
Publisher: name: Zenodo
Year: 2024
Subjects: PALOMERA
open access
open access books
policy brief

description: This deliverable is the second policy brief provided by the PALOMERA project. It provides an overview of the analysis performed in the project, its main results and methodology. Based on this research general and stakeholder specific recommendations have been formulated in actionable ways. The policy brief provides an oversight of this important outcome of the project. Furthermore, it describes other key results like the Knowledge Base (consisting of around 650 policy and policy-related documents), an extended OAPEN OA Books Toolkit (now including a policy section with 15 new articles presenting key findings of the project in an easy digestible format), and the establishment of a Funder Forum that key stakeholders like Science Europe, cOAlition S, and OAPEN are seeking to continue and coordinate as a Policy Forum for Open Access Books. The policy brief concludes by highlighting three PALOMERA recommendations that could be useful starting points for further advancing Open Access to books.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
Impact of white matter hyperintensity volume on cognition among US Mexican American adults.
Creators: name: Diaz, Monica M
name: Graves, Lisa V
name: Dayan, Eran
Publisher: name: Cambridge University Press (CUP)
Year: 2024

description:
OBJECTIVE: Higher white matter hyperintensity (WMH) volume is a marker of cardiovascular disease (CVD) risk. CVD risk factors increase risk for Alzheimer's disease and related dementias (ADRD). Mexican Americans (MA) and individuals of other Hispanic/Latino heritages have higher risk for CVD and ADRD. However, knowledge of associations between WMH volume and cognition in these groups remains limited. METHOD: We conducted a cross-sectional study of associations between WMH volume and neuropsychological performance (attention/executive functioning, memory) in MA (n = 851) and non-Hispanic White (NHW; n = 747) adults in the Health and Aging Brain Study: Health Disparities. RESULTS: The MA group (mean age = 63.72 ± 7.90 years; 66.3% female) had higher rates of consensus diagnoses of hypertension and diabetes, whereas the NHW group (mean age = 69.18 ± 8.65 years; 55.2% female) had higher rates of diagnosed CVD (ps < .01). WMH volumes were higher among individuals with CVD risk factors/conditions (ps < .01). There were differential associations between WMH and neuropsychological performance across ethnoracial groups (ps < .001), wherein associations were steeper in the NHW group than in the MA group. Lower educational level was associated with higher WMH volume in the NHW group (p < .001), but no association was seen in the MA group (p > .05). CONCLUSIONS: Negative effects of pathological changes in the form of WMH on cognition may be less robust or consistent for MA adults than NHW adults. Furthermore, the impact of WMH on cognition in NHW adults may be mitigated by cognitive reserve related to educational attainment.
ABC Transporters
Creators: name: Cole, Hannah
Publisher: name: Zenodo
Year: 2023

description: Creative Biogene offers a wide range of ABC transporters assays, including P-gp (MDR1/ABCB1), BCRP (ABCG2) and BSEP (sPgp/ABCB11), etc. P-gp, BCRP and BSEP are highly expressed in the luminal membrane of enterocytes, endothelial cells in the brain, the border membrane of renal proximal tubules and canalicular membrane of hepatocytes. In these positions, the intestinal absorption, blood-brain barrier penetration and facilitate excretion into the bile and urine were limited.
Qvirus Platform
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: As a Contract Development and Manufacturing Organization (CDMO), we arededicated to providing end-to-end services that adhere to the regulatory requirements set forth by regulatory bodies such as the FDA, NMPA, and EMA for gene therapy products. Our commitment to compliance and quality ensures that the gene therapy products developed through our services meet the highest standards.

At Creative Biogene, we emphasize technological innovation and continuous production to accelerate the development process and reduce production costs. By leveraging our expertise and state-of-the-art facilities, we strive to contribute to the success of our customers' gene therapy endeavors with qvirus platform.
Assay-based background projection for the Majorana Demonstrator using Monte Carlo uncertainty propagation
Creators: name: Elliott, S. R.
name: Oli, T. K.
name: Paudel, L. S.
name: Martin, R. D.
name: Blalock, E.
name: Clark, M. L.
name: Guiseppe, V. E.
name: Schaper, D. C.
name: V., T. E. Lannen
name: Ruof, N. W.
name: Efremenko, Yu.
name: Bos, B.
name: Aguilar, D. Hervas
name: Avignone, F. T.
name: Kidd, M. F.
name: Cuesta, C.
name: Reine, A. L.
name: Henning, R.
name: Barabash, A. S.
name: Fuad, N.
name: Gruszko, J.
name: Chan, Y.-D.
name: Green, M. P.
name: Hoppe, E. W.
name: Chu, P.-H.
name: Wiseman, C.
name: Haufe, C. R.
name: Massarczyk, R.
name: Arnquist, I. J.
name: Yu, C.-H.
name: Li, A.
name: Guinn, I. S.
name: Pettus, W.
name: Wilkerson, J. F.
name: Giovanetti, G. K.
name: Barton, C. J.
name: López-Castaño, J. M.
name: Xu, W.
name: Christofferson, C. D.
name: Meijer, S. J.
name: Ejiri, H.
name: Watkins, S. L.
name: Busch, M.
name: Hostiuc, A.
name: Detwiler, J. A.
name: Schleich, S. J.
name: Kouzes, R. T.
name: Caldwell, T. S.
name: Tedeschi, D.
name: Rielage, K.
name: Kim, I.
name: Poon, A. W. P.
name: Radford, D. C.
name: Bhimani, K. H.
name: Vasilyev, S.
name: Varner, R. L.
Publisher: name: American Physical Society (APS)
Year: 2024

description:
The background index (BI) is an important quantity to project and calculate the half-life sensitivity of neutrinoless double-β decay (0νββ) experiments. An analysis framework is presented to calculate the BI using the specific activities, masses, and simulated efficiencies of an experiments components as distributions. This Bayesian framework includes a unified approach to combine specific activities from assay. Monte Carlo uncertainty propagation is used to build a BI distribution from the specific activity, mass, and efficiency distributions. This method is applied to the Majorana Demonstrator, which deployed arrays of high-purity Ge detectors enriched in Ge76 to search for 0νββ. The original assay-based projection is requantified in the new framework, using the as-built geometry of the Demonstrator and additional assay information. While 47% higher than the original projection, the resulting BI of [8.95±0.36]×10−4cts/(keVkgyr) from the Th232 and U238 decay chains does not account for the higher-than-expected BI observed by the Demonstrator. This method enables us to demonstrate the statistical incompatibility between the Demonstrator's observed background and the assay results.
Freianlagen: Ausführung
Creators: name: Müller, A.
name: Brandt, C.
name: Burgherrr, H.R.
name: Fleischmann, T.
name: Graber, H.
name: Heuerding, E.
name: Moser, H.J.
Publisher: name: Bundesamt für Sport BASPO
Year: 1991
Subjects: Freianlagen Ausführung Sport Sportanlagen

description: Bautechnische Grundlagen für Freianlagen. Auswahlkriterien, Regelaufbauten, Pflege- und Unterhaltshinweise für Sportbeläge. Angaben über Beleuchtungs-, Beschallungs- und andere Einrichtungen, Nebenanlagen und Umgebungsarbeiten.
Genome Editing
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Reporter genes can be inserted into specific genomic sites of interest by homologous recombination. The targeting construct composed of a core region carrying the reporter cassette is flanked by homology arms which recombine with the target genomic loci, leading to site-specific insertion of the reporter. The process is very inefficient, generally occurring at a rate of one in a million cells which can be significantly enhanced in the presence of double-strand breaks. New gene- targeting technologies aim to precisely cleave genomic loci to facilitate insertion or deletion of genes at the specific cleavage site (Figure. 2). Some reporter lines in ESC and iPSC have been generated using these methods.
PALOMERA D5.1 – Dissemination, outreach, engagement, and exploitation plan
Creators: name: Rabar, Ursula
name: Barnes, Lucy
name: Proudman, Vanessa
Publisher: name: Zenodo
Year: 2023
Subjects: community
Europe
dissemination
Horizon Europe
monograph
OA books
open access
open science
PEDR
scholarly communication
communication
PALOMERA

description: The Dissemination, outreach, engagement, and exploitation plan (PEDR) describes the methodology across the PALOMERA project as a guideline for the activities of all project partners when sharing information about the project, engaging with the community, reaching out to it as well as the activities to be carried out to enhance the successful exploitation of the project results. The guide identifies the strategy for dissemination, outreach, engagement, and exploitation, and describes the various channels that the project uses. It is complemented by the Communications Kit developed separately that provides an overview of items available to all project partners for download. The PEDR is a living document. Its structure mainly follows the template suggested in the PALOMERA Grant Agreement (proposal part). It will be updated during the project implementation and tailored to the project’s needs and progress on demand. The current document is a first draft of the PEDR and will be updated at the end of each reporting period (M9, M24). Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
Plasmid DNA Production
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene is a biotechnology company specializing in custom plasmid DNA production service. With years of experience in service of plasmid DNA production, Creative Biogene can offer customized plasmid services at scales from micrograms to grams using Creative Biogene’s unique and proprietary process. Besides, Creative Biogene can provide you with multiple quality grades’ plasmids, including research grade, endo-toxin free grade and GMP grade plasmid DNAs. Creative Biogene’s goal is to provide you with the most affordable, high-quality plasmid DNA manufacturing services to ensure your satisfaction in a timely and professional manner.
Adenovirus Particles
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: As a leader in adenoviral technology, Creative Biogene has developed a comprehensive library of human, mouse, and rat genes cloned into adenoviral vectors or ready-to-use adenoviruses, which can be used to manipulate the expression of your gene of interest within a wide range of host cells. Creative Biogene offers many different kinds of premade adenoviruses containing full-length ORFs of particular genes or shRNA/miRNA with a choice of different tags or reporter genes as you want.
title: "Una lezione d'anatomia", cerchia di Passerotti Bartolomeo / attribuito a Zuccari Federico, inv. 460 (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Puddu, Pier Ludovico
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
miRNA Antagomir
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene's microDOWN™ miRNA antagomir is single-strand miRNA inhibitor carrying the chemically modifications functioning by blocking miRNA regulation of target gene expression efficiently. The strand of the antagomir has 2 phosphorothioates at the 5' end, 4 phosphorothioates, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. Stability of microDOWN™ miRNA antagomir appears to be significantly higher than miRNA inhibitors. It exhibits enhanced cellular uptake, stability and regulatory activity and is recommended for miRNA functional studies in vitro and in vivo.
Effects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial
Creators: name: Marcin, Thimo
name: Hautz, Stefanie C.
name: Singh, Hardeep
name: Zwaan, Laura
name: Schwappach, David
name: Krummrey, Gert
name: Schauber, Stefan K.
name: Nendaz, Mathieu
name: Exadaktylos, Aristomenis Konstantinos
name: Müller, Martin
name: Lambrigger, Cornelia
name: Sauter, Thomas C.
name: Lindner, Gregor
name: Bosbach, Simon
name: Griesshammer, Ines
name: Hautz, Wolf E.
Publisher: name: BMJ Group
Year: 2023

description: Introduction Computerised diagnostic decision support systems (CDDS) suggesting differential diagnoses to physicians aim to improve clinical reasoning and diagnostic quality. However, controlled clinical trials investigating their effectiveness and safety are absent and the consequences of its use in clinical practice are unknown. We aim to investigate the effect of CDDS use in the emergency department (ED) on diagnostic quality, workflow, resource consumption and patient outcomes. Methods and analysis This is a multicentre, outcome assessor and patient-blinded, cluster-randomised, multiperiod crossover superiority trial. A validated differential diagnosis generator will be implemented in four EDs and randomly allocated to a sequence of six alternating intervention and control periods. During intervention periods, the treating ED physician will be asked to consult the CDDS at least once during diagnostic workup. During control periods, physicians will not have access to the CDDS and diagnostic workup will follow usual clinical care. Key inclusion criteria will be patients’ presentation to the ED with either fever, abdominal pain, syncope or a non-specific complaint as chief complaint. The primary outcome is a binary diagnostic quality risk score composed of presence of an unscheduled medical care after discharge, change in diagnosis or death during time of follow-up or an unexpected upscale in care within 24 hours after hospital admission. Time of follow-up is 14 days. At least 1184 patients will be included. Secondary outcomes include length of hospital stay, diagnostics and data regarding CDDS usage, physicians’ confidence calibration and diagnostic workflow. Statistical analysis will use general linear mixed modelling methods. Ethics and dissemination Approved by the cantonal ethics committee of canton Berne (2022-D0002) and Swissmedic, the Swiss national regulatory authority on medical devices. Study results will be disseminated through peer-reviewed journals, open repositories and the network of investigators and the expert and patients advisory board.
A History of Rezoning Legislation in Goochland County, Virginia with Special Attention to Conditional Zoning
Creators: name: Ellis, Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description:
Goochland County is a suburban and rural community on western end of the Greater Richmond Metropolitan Area. The County has experienced substantial ongoing urban development. As such, to facilitate demand for development the County has periodically amended, as is typical for all localities with comprehensive zoning, the County zoning map which was adopted with the County’s original zoning ordinance in 1969. Since the General Assembly of Virginia passed the enabling legislation for conditional zoning, the County has been able to accept proffered conditions from applicants requesting a rezoning classification from the Goochland County Board of Supervisors. Conditional Zoning allows for applicants to offer up voluntarily restrictions more stringent than the underlying zoning district requirements or provide certain benefits not required by the zoning ordinance. It is generally considered to be a form of bargain-based planning. An analysis of all rezoning cases brought before the Board of Supervisors reveals a heavy use of proffered conditions by applicants in the County. In fact, most acreage in a majority of the County’s zoning districts are subject to proffered conditions. These conditions largely focus on concerns with buffers and transportation. Moreover, the number of conditions accepted by the Board of Supervisors, which are added to the zoning ordinance, is quite numerous—at least seven times longer than existing zoning ordinance. Bargain-based planning appears to be the default mode of planning in this county. Furthermore, the knowledge, upkeep, and enforcement of these conditions represents an underappreciated draw on a municipal planner’s time.
Zoom auf... Die Kreislaufanlage
Creators: name: Nipp, Eno
Publisher: name: Berner Fachhochschule, Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften HAFL
Year: 2021
Subjects: Aquakultur Aquaculture

description: Um die heimische Fischproduktion fit für die Zukunft zu machen, haben die BFH-HAFL und das INFORAMA gemeinsam das «Aquaforum» lanciert: ein Kompetenzzentrum für Forschung, Bildung und Dienstleistung im Bereich Aquakultur. Ein wichtiger Meilenstein ist die Inbetriebnahme einer modernen Kreislaufanlage mit Fischtanks auf dem Gelände des INFORAMA Rütti in Zollikofen.
description: La BFH-HAFL et INFORAMA ont récemment fondé « Aquaforum », un centre de compétence pour la recherche, la formation et les prestations de services aquacoles. Son objectif : consolider et pérenniser la production aquacole indigène. Un élément clé d’Aquaforum est une installation à recirculation dernier cri équipée d’aquariums, qui vient d’être mise.
PALOMERA D5.1 – Dissemination, Outreach, Engagement and Exploitation Plan
Creators: name: Ursula Rabar
Publisher: name: Zenodo
Year: 2023
Subjects: community
Europe
dissemination
Horizon Europe
monograph
OA books
open access
open science
PEDR
scholarly communication
communication
PALOMERA

description: The Dissemination, Outreach, Engagement and Exploitation plan (PEDR) describes the methodology across the PALOMERA project as a guideline for the activities of all project partners when sharing information about the project, engaging with the community, as well as the activities to enhance the successful exploitation of the project results. The guide identifies the strategy for dissemination, outreach, engagement, and exploitation, and describes the various channels that the project used. It is complemented by the Communication kit developed separately that provides an overview of items available to all project partners for download. The PEDR was a living document evolving for the duration of the project. Its structure mainly followed the template suggested in the PALOMERA Grant Agreement (proposal part). It was updated during the project implementation and tailored to the project's needs and progress on demand. The current document is the final M24 updated version.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
Microbial Identification
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2023

description: Microbial identification methods include morphological observation, identification of physiological and biochemical characteristics, automatic analysis and identification of BIOLOG carbon source, molecular biology identification, numerical identification of API bacteria, functional analysis and functional gene, RAPD, SSCP, TLC thin layer chromatography, whole cell fatty acid analysis and identification, (G+C) mol% determination, DNA/DNA homology determination, etc.
Sozialstaat
Etat social
Creators: name: Beyeler, Michelle
Publisher: name: Seismo
Year: 2020

description: Der Sozial- oder Wohlfahrtsstaat ist das institutionelle Fundament des staatlichen Handelns, das auf die Absicherung von Lebensrisiken, die Reduktion von Ungleichheit und Armut sowie die Förderung von Chancengleichheit zielt. Im Kern bedeutet Sozialstaatlichkeit, dass grundlegende Belange der privaten Wohlfahrt zum Gegenstand staatlicher Politik werden. Durch die Garantie von Ansprüchen auf Grundsicherung und weiteren Sozialrechten auf Verfassungs- und Gesetzesstufe übernimmt die Gesellschaft formal und somit ausdrücklich Verantwortung für das Wohlergehen ihrer Mitglieder.
description: L’État social, ou État-providence, est le fondement institutionnel de l’action de l’État visant à couvrir les risques de la vie, à réduire les inégalités et la pauvreté et à promouvoir l’égalité des chances. En substance, l’État social signifie que les préoccupations fondamentales du bienêtre privé deviennent l’objet de la politique de l’État. En garantissant les droits à la couverture des besoins vitaux et d’autres droits sociaux aux niveaux constitutionnel et législatif, la société endosse formellement et explicitement la responsabilité du bien-être de ses membres.
HPV Pseudoviruses
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Pseudoviruses (PsV) are closely related to the structures and characteristics of its native viruses, but lack some characteristics of the native viruses such as capability for replication. The HPV PsV system has been widely used in the HPV research field because the property of HPV PsV is similar to that of native HPV virion. The capsid of HPV consists of 72 homo-pentameric capsomers of the major structural protein L1 and a variable number (12–72 copies) of the minor structural protein L2. L1 and L2 proteins can be assembled spontaneously into virus-like particles (VLPs) and package either HPV viral genome or non-viral DNA.
Strategies for training and knowledge exchange with a consulting perspective
Creators: name: Paladin, Lisanna
name: Kaspar, Sarah
name: Mueller, Rabea
name: Förstner, Konrad
name: Di Giorgio, Silvia
Publisher: name: Zenodo
Year: 2024
Subjects: Train the Trainer
Mentoring
Community engagment
knowledge-exchange
Classical training
Consulting

description:  

These presentations were part of the BioNT workshop "Strategies for training and knowledge exchange with a consulting perspective" held on June 25-26, 2024.

Please note that we have compiled a comprehensive handbook linking all the presentation slides, organized according to the schedule of the workshop. This handbook is designed to provide you with easy access to all the materials covered, enabling you to review the topics at your own pace and delve deeper into the content discussed.

 

Organisers

Silvia Di Giorgio (ZB MED – Information Centre for Life Sciences)

Rabea Müller (ZB MED – Information Centre for Life Sciences)

Trainers

Konrad Förstner (ZB MED - Information Centre for Life Sciences)

Sarah Kaspar (EMBL - Heidelberg)

Rabea Müller (ZB MED - Information Centre for Life Sciences)

Lisanna Paladin (EMBL - Heidelberg)

 

 Further information about the workshop can be found on the Workshop Website.
Baculovirus Services
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2023

description: Creative Biogene, a leading biotechnology service vendor in the world, has years of professional and abundant experience which are available to provide you a full spectrum of high quality baculovirus services ranging from baculovirus transfer vector construction, recombinant bacmid DNA preparation, baculovirus production as well as baculovirus titer assay. Creative Biogene is a reliable partner that can work with you to accelerate the speed to achieve your research goals.
MAPEAMENTO DA JUSTIÇA RESTAURATIVA NOS TRIBUNAIS DE JUSTIÇA BRASILEIROS
Creators: name: Adélia Campos FONSECA
name: Christiane de Holanda CAMILO
Publisher: name: Zenodo
Year: 2024
Subjects: Justiça Restaurativa
Me´todos Adequados de Resoluça˜o de Conflitos
Mapeamento
Tribunais de Justiça
Cí´rculos de Paz

description: RESUMO

A Justiça Restaurativa e´ uma realidade em va´rios paí´ses no mundo, inclusive no Brasil, onde passa por um momento de expansa˜o dentro do Poder Judicia´rio. O objetivo desta pesquisa e´ realizar um mapeamento da aplicaça˜o da Justiça Restaurativa nos tribunais de justiça brasileiros. Esta e´ uma pesquisa qualiquantitativa, explorato´ria, bibliogra´fica e documental. Ao final, foi possí´vel observar que o Judicia´rio tornou a Justiça Restaurativa uma polí´tica institucionalizada e encontra-se, documentalmente, amplamente difundida.
Der neue Fokus auf Chancengerechtigkeit in der Palliative Care
Creators: name: Soom Ammann, Eva
Publisher: name: Schweizerische Gesellschaft für Palliative Medizin, Pflege und Begleitung
Year: 2024

description: Palliative Care für alle – was ist damit eigentlich gemeint, und was bedeutet der neue Fokus auf Chancengerechtigkeit für die Palliative Care? Dieser Beitrag skizziert aus der Perspektive gesundheitlicher Ungleichheitsforschung die Begriffe Diversität, Chancengerechtigkeit und Zugang und zeigt auf, warum auch die Palliative Care sich selbstkritisch damit auseinandersetzen muss.
Ion Channel Screening
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene has generated an extensive panel of ion channel screening assays comprising more than 80 ion channel targets and over 200 ion channel assays. In terms of conventional patch clamp electrophysiology, automated electrophysiology, and fluorescence assays, Creative Biogene can offer a wide range of binding and functional assays for ion channel assays to quickly and accurately provide results for drug discovery.
PV-Based ELISA-Like Diagnosis
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene has rich history of success and commitment to providing our clients with the best service using only state-of-the-art equipment and finest materials. Coming from world renowned institutions around the globe, researchers of our laboratory team are well-trained and highly experienced with the devotion and dedication to fulfill any requirements by our clients to satisfactory. At Creative Biogene, industry-leading PV customization service is offered to all of our clients at competitive pricing with rapid turnaround time, ensuring an easy and trouble-free start of your research.
Network centrality and credit risk: A comprehensive analysis of peer-to-peer lending dynamics
Creators: name: Baals, Lennart John
name: Liu, Yiting
name: Osterrieder, Jörg Robert
name: Hadji Misheva, Branka
Publisher: name: Elsevier
Year: 2024
Subjects: Peer-to-Peer lending Credit-default prediction Machine Learning Network centrality

description: This letter analyzes credit risk assessment in the Peer-to-Peer (P2P) lending domain by leveraging a comprehensive dataset from Bondora, a leading European P2P platform. Through combining traditional credit features with network topological features, namely the degree centrality, we showcase the crucial role of a borrower’s position and connectivity within the P2P network in determining loan default probabilities. Our findings are bolstered by robustness checks using shuffled centrality features, which further underscore the significance of integrating both financial and network attributes in credit risk evaluation. Our results shed new light on credit risk determinants in P2P lending and benefit investors in capturing inherent information from P2P loan networks.
mRNA-LNP Encapsulation
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: LNPs are liposome-like structures, engineered for encapsulating a broad variety of nucleic acids (RNA, mRNA, siRNA, gRNA, circRNA and DNA) and APIs; LNPs consist in an aqueous core surrounded by a lipidic shell based on a combination of 4 families of chemicals: an ionizable cationic lipid, a polyethylene-glycol (PEG) lipid, cholesterol, and a helper phospholipid. The ionizable cationic lipids are used to sequester the nucleic acids through charge absorption. The PEG lipids are incorporated to increase the circulatory half-life in the body. Cholesterol is a structural "helper" lipid that improves efficacy possibly by promoting membrane fusion and promoting endosomal escape. Similarly, the helper phospholipids are also commonly used in LNP formulation to promote cell binding.
MOESM1 of Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticityÂ by HDAC inhibitors
Creators: name: Lennartsson, Andreas
name: Arner, Erik
name: Fagiolini, Michela
name: Saxena, Alka
name: Andersson, Robin
name: Hazuki Takahashi
name: Noro, Yukihiko
name: Sng, Judy
name: Sandelin, Albin
name: Hensch, Takao
name: Carninci, Piero
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 1: Figure S1. DHSS and transcription start sites. DHSS overlap more with highly expressed than low expressed genes in both VPA (A) and vehicle (B) treated animals. DHSS are enriched in broad promoters compared to single peak promoters in both VPA (C) and Veh (D) treated animals. (E) DHSS are enriched in the Alu/B1 subclass of SINE elements.
Cyperus difformis L.
Creators: name: Info Flora
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Cyperus
Cyperus difformis

description: Cyperus difformis L.
Missgestaltetes Cypergras
Art ISFS: 129600 Checklist: 1014350 Cyperaceae Cyperus Cyperus difformis L.
Bestimmungsschlüssel
Zusammenfassung
Artbeschreibung (nach Lauber & al. 2018): wie C. fuscus, aber 20-60 cm hoch, je 30-120 Ährchen in dichten, kugeligen Köpfen. Tragblätter grünlich bis rotbraun, vorn breit abgerundet.
Standort und Verbreitung in der Schweiz (nach Lauber & al. 2018): Nasse Äcker, Ufer / kollin / TI
Verbreitung global (nach Lauber & al. 2018): Subtropisch
Ökologische Zeigerwerte (nach Landolt & al. 2010) 4 + w + 34-452.t
Ökologie
Lebensraum Lebensraumnach Delarze & al. 2015
KEINE ANGABE
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Nomenklatur
Gültiger Name (Checklist 2017):Cyperus difformisL.
Volksname Deutscher Name: Missgestaltetes Cypergras Nom français: Souchet difforme Nome italiano: Zigolo delle risaie
Übereinstimmung mit anderen Referenzwerken
RelationNomReferenzwerkeNo=Cyperus difformis L.Checklist 2017129600=Cyperus difformis L.Index synonymique 1996129600=Cyperus difformis L.Landolt 1977407=Cyperus difformis L.SISF/ISFS 2129600
= Taxon stimmt mit akzeptiertem Taxon überein (Checklist 2017)  Taxon enthält (neben anderen) auch das akzeptierte Taxon (Checklist 2017)
Status Indigenat: Neophyt: nach der Entdeckung von Amerika in der Region aufgetreten (nach 1500)
Liste der gefährdeten Pflanzen IUCN(nach Walter & Gillett 1997): Nein
description: Published as part of Info Flora, 2021,
cDNA Library Construction
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: As a pioneer biotechnology company in the world, Creative Biogene can provide high quality cDNA libraries construction service to customers worldwide. Creative Biogene’s advanced technologies and highly experienced staffs are available to provide you a range of cDNA libraries construction service, including standard cDNA library, subtractive cDNA library, normalized cDNA library, full length cDNA library, yeast two-hybrid cDNA library and SSH cDNA library. Creative Biogene’s goal is to provide you with the most affordable and high-quality cDNA libraries construction service to ensure your satisfaction in a timely and professional manner.
Reporter AAV Particles
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Adeno-associated virus (AAV) is a powerful vector system used to transduce cells in vivo. Recombinant AAV can efficiently deliver genetic material to both dividing and non-dividing cells. AAV is replication-defective, nonpathogenic, and noncytotoxic, and can maintain physiologically relevant expression levels in cells and tissues. Currently, AAV has become one of the most promising viral vectors for gene therapy.
Gene Knockout Stable Cell Lines
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: The CRISPR/Cas9 system is an adaptive immunity system in bacteria against bacteriophage invading. It has been developed as the most popular method for genome editing in recent years. Creative Biogene is offering a series of gene knockout cell lines developed by the CRISPR/Cas9 system. Our scientists have years of experience in performing gene editing with CRISPR/Cas9, from designing gRNA to transfection and single clone generation. These cell lines provide you with a convenient means to study gene functions.
Premade Lentivirus Particles
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: As a leader in lentiviral technology, Creative Biogene has developed a comprehensive library of human, mouse, and rat genes cloned into lentiviral vectors or ready-to-use lentivirus, which can be used to manipulate the expression of your gene of interest within a wide range of host cells. Our comprehensive suite of lentiviral solutions includes ready-to-use particles suitable for use in cell culture and animals, plasmid clones expressing ORF, miRNA, shRNA, and sgRNA. Additionally, we offer lentivirus expression plasmid with desired promoters or tags.
Oligonucleotide Synthesis Service
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene is one of the leading biotechnology companies which has the expertise and ability in providing oligonucleotide synthesis service for customers worldwide. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to provide you a full spectrum of high quality specialty oligonucleotide synthesis service ranging from oligo synthesis for research and GMP grade, modified oligonucleotides to high throughput DNA or RNA oligo synthesis.
GFP Labelled Human Metapneumovirus
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Human metapneumovirus (MPV) is a negative single-stranded RNA virus which belongs to the Pneumovirinae subfamily of the Paramyxoviridae family. MPV can cause respiratory diseases in humans. This virus is an engineered recombinant Human MPV expressing the green fluorescent protein (GFP). It can replicate as efficiently as its parental strain in host cells which allows researchers to use it as an efficient tool for studying Human MPV. This virus should be handled in BSL2 facilities.
PCR Detection Kit Development
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Leveraging the deep domain expertise of its IVD Kit developers, Creative Biogene has rapidly developed and manufactured nucleic acid-based detection kits for both local and international partners and clients. Creative Biogene offers full-cycle development services for in vitro diagnostic (IVD) kits and assays from sample preparation and sample matrix to data analysis that can be seamlessly adapted to your project requirements.
Microbial Identification
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene is a leading biotechnology company offering a suite of trusted services and solutions for identification, classification, quantitation and functional analysis of microbes in complex biological mixtures. Whether you are performing sequencing for discovery, characterization, or routine microbial identification, Creative Biogene technologies provide versatile approaches to meet your needs. Microbial identification methods include morphological observation, identification of physiological and biochemical characteristics, automatic analysis and identification of BIOLOG carbon source, molecular biology identification, numerical identification of API bacteria, functional analysis and functional gene, RAPD, SSCP, TLC thin layer chromatography, whole cell fatty acid analysis and identification, (G+C) mol% determination, DNA/DNA homology determination, etc. Our company specializes in microbial identification as well as custom sequencing project services with highly competitive prices and fast turnaround times. With talented stuffs and over years of experience, we can totally satisfy your project requirements and budgets in the exploration of microbial biodiversity.
HPV Real Time PCR Kit
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene HPV 16&18 Real Time PCR Kit is used for the detection of Human papillomavirus (HPV) type 16&18 by using real time PCR systems. The human papilloma virus (HPV) is one of the most common virus groups in the world to affect the skin and mucosal areas of the body. The kit contains a specific ready-to-use system for the detection of the Human papillomavirus (HPV) type 16&18. Fluorescence is emitted and measured by the real time systems' optical unit during the PCR.
Adipositas und Geburt : die Suche nach der «optimalen» Betreuung
Creators: name: Wyss, Carmen
name: Aubry, Evelyne
Publisher: name: Schweizerischer Hebammenverband (SHV)
Year: 2019

description: Adipositas ist ein weltweites Gesundheitsproblem. Die steigende Prävalenz bei Frauen im reproduktiven Alter fordert eine entsprechende Anpassung von deren geburtshilflicher Gesundheitsversorgung. Vermutet wird, dass sich mit geeigneter Betreuung die Gesundheit von betroffenen Frauen und ihren Kindern positiv beeinflussen lässt. Ein Forschungsprojekt an der Berner Fachhochschule Gesundheit lotet die Möglichkeiten einer verbesserten Geburtsbetreuung von Frauen mit Adipositas aus.
Eye-tracking the cancellation and focus model for preference judgments
Creators: name: Brunner, Thomas
name: Sütterlin, Bernadette
name: Opwis, Klaus
Publisher: name: Elsevier
Year: 2008
Subjects: Feature matching
Direction of comparison
Preference judgments
Feature attractiveness
Franklin’s rule
WReSt heuristic

description: By means of a relatively new eye-tracking method that allows for a test situation much closer to reality, we recorded and examined gaze time and fixation number within the cancellation and focus paradigm, a feature-matching model for preference judgments between two alternatives. In line with the cancellation and focus model we found that when subjects encountered the second option in each pair, shared features were canceled out and thus given less consideration whereas unique features were focused on more. We also investigated the role of feature attractiveness as a second important factor in preference judgments and found a U-shaped relationship between attractiveness and visual consideration intensity; that is, attractive and unattractive features received more attention than did those of intermediate attractiveness. Finally, we tested the ability of two models, Franklin’s rule and the WReSt (Weighted Recalled Stepwise Comparing) heuristic, to predict the preference ratings.
Custom Libraries Construction
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2023

description: Creative Biogene has extensive expertise and experience to provide you with custom libraries construction service. In terms of sophisticated equipments, advanced technologies and highly experienced staffs, Creative Biogene can provide you with a range of custom libraries construction service, including cDNA library, genomic library, BAC library, mutant library, shotgun library, etc. Creative Biogene's goal is to provide you with the most affordable and high-quality custom libraries construction service to ensure your satisfaction in a timely and professional manner.
Property changes in thermo-hydro-mechanical processing
Creators: name: Navi, Parviz
name: Pizzi, Antonio
Publisher: name: De Gruyter
Year: 2015

description: Thermo-hydro-mechanical (THM) treatment is a combined action of temperature, moisture, and mechanical force, which leads to modified wood (THMW). Various types of eco-friendly THM processes have been developed to enhance wood properties and generate new materials, such as welding, densification, molding, bending, profiling, artificial aging, panel manufacture, and surface densification. The various transformation processes in the course of THM bring about positive effects in terms of the mechanical and physical properties as well as the biological durability. To the negative effects belong the loss in strength and fracture toughness, and one of the challenges is to minimize these negative aspects. The present paper reviews the chemical transformations processes during THM treatment in a closed processing system and presents the relationship between processing parameters and THMW properties. The discussion includes the problems associated with eliminating the set recovery of densified wood by THM posttreatments and the chemical origin of the relaxation of internal stresses induced by densification.
CRISPR Library Screening
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: The application of CRISPR libraries makes large-scale genome editing and screening in basic research a reality. Creative Biogene helps clients unlock the full potential of their genetic research with our advanced CRISPR screening services. We offer a large number of CRISPR libraries to meet the research demands of different customers, including human whole-genome knockout libraries, mouse whole-genome knockout libraries, pathway-associated gRNA libraries, CRISPRa libraries, CRISPRi libraries, and customized gRNA libraries. Our cutting-edge technology enables high-throughput and scalable screening of genome-wide libraries for rapid identification of novel gene functions, discovery of gene interactions and exploration of complex signaling pathways.
Minimal Out-Toeing and Good Hip Scores of Severe SCFE Patients Treated With Modified Dunn Procedure and Contralateral Prophylactic Pinning at Minimal 5-year Follow up
Creators: name: Lerch, Till D
name: Boschung, Adam
name: Leibold, Christian
name: Kalla, Roger
name: Kerkeni, Hassen
name: Baur, Heiner
name: Eichelberger, Patric
name: Steppacher, Simon D
name: Liechti, Emanuel F
name: Siebenrock, Klaus A
name: Tannast, Moritz
name: Ziebarth, Kai
Publisher: name: Wolters Kluwer
Year: 2022

description: Background: Slipped capital femoral epiphyses (SCFE) is associated with out-toeing of the foot and external rotation gait. But it is unknown if SCFE patients treated with the modified Dunn procedure have out-toeing at follow up.Therefore, we used instrumented gait analysis and questioned (1) do severe SCFE patients treated with a modified Dunn procedure have symmetrical foot progression angle (FPA) compared with contralateral side and compared with asymptomatic volunteers (2) what is the prevalence of out-toeing gait and what are the outcome socres at follow up. Methods: Gait analysis of 22 patients (22 hips) treated with an unilateral modified Dunn procedure for severe SCFE (slip angle >60 degrees, 2002 to 2011) was retrospectively evaluated. Of 38 patients with minimal 5-year follow up, 2 hips (4%) had avascular necrosis of the femoral head and were excluded for gait analysis. Twenty-two patients were available for gait analysis at follow up (mean follow up of 9±2 y). Mean age at follow up was 22±3 years. Mean preoperative slip angle was 64±8 degrees (33% unstable slips) and decreased postoperatively (slip angle of 8±4 degrees). Gait analysis was performed with computer-based instrumented walkway system (GAITRite) to measure FPA with embedded pressure sensors. Patients were compared with control group of 18 healthy asymptomatic volunteers (36 feet, mean age 29±6 y). Results: (1) Mean FPA of SCFE patients (3.6±6.4 degrees) at follow up was not significantly different compared with their contralateral side (5.6±5.5 degrees) and compared with FPA of controls (4.0±4.5 degrees). (2) Of the 22 SCFE patients, most of them (19 hips, 86%) had normal FPA (-5 to 15 degrees), 2 patients had in-toeing (FPA<-5 degrees) and 1 had out-toeing (FPA >15 degrees) and was not significantly different compared with control group. (3) Mean modified Harris hip score (mHHS) was 93±11 points, mean Hip Disability and Osteoarthritis Outcome Score (HOOS) score was 91±10 points. Three patients (14%) had mHHS <80 points and walked with normal FPA. The 2 patients with in-toeing and one patient with out-toeing had mHHS >95 points. Conclusions: Patients with severe SCFE treated with modified Dunn procedure had mostly symmetrical FPA and good hip scores at long term follow up. This is in contrast to previous studies. Although 1 patient had out-toeing and 2 patients had in-toeing at follow up, they had good hip scores. Level of evidence: Level III-retrospective comparative study.
Custom Viral Service
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene provides world-class packaging services for a variety of viral types using our QVirusTM platform. Creative Biogene's state-of-the-art facilities and highly experienced staff are available in order to assist in all areas of virus vector design and construction, as well as the generation of the virus in a quick turnaround. Our custom viral services are highlighted by a consistent high titer and large delivery viral counts.
Bacillus Strain Selection
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Bacillus species continue to be dominant bacterial workhorses in microbial fermentation. Some Bacillus species are on the Food and Drug Administration's GRAS (generally regarded as safe) list. The capacity of selected Bacillus strains to produce and secrete large quantities of extracellular enzymes has placed them among the most important industrial enzyme producers. The ability of different species to ferment in the acid, neutral, and alkaline pH ranges, combined with the presence of thermophiles in the genus, has led to the development of a variety of new commercial enzyme products with the desired temperature, pH activity, and stability properties to address a variety of specific applications. Classical mutation and (or) selection techniques, together with advanced cloning and protein engineering strategies, have been exploited to develop these products.