cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigations of DNA damage in living cells: Application of the comet assay and the development of a novel time-resolved fluorescence measurement technique.
Creators: name: Vinette, Anne L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Molecular.

description: Non-steroidal anti-inflammatory drug (NSAID) photo-induced DNA damage in human peripheral blood mononuclear cells measured using the alkaline comet assay is presented. Whereas Tiaprofenic Acid photo-induced DNA damage is promptly produced (i.e., observed at low radiation doses), Ketoprofen (KP) photo-induced DNA damage is delayed (observed at relatively higher radiation doses). This prompt and delayed effect is observed with UVA (320--400 nm), UVB (290--320 nm) and solar simulated radiation and is attributed to the NSAIDs' different photochemical properties. The results from these experiments mark the first account of NSAID photo-induced DNA damage in living cells. The neutral version of the comet assay, carried out using HL60 cells, revealed that KP photo-induced DNA damage did not lead to apoptosis, indicating that HL60 cells can sustain and possibly recover from this damage. A new technique for measuring DNA damage based on the time-resolved fluorescence decay measurements of PicoGreenRTM-DNA complexes is also presented. PicoGreenRTM exhibits a longer fluorescence lifetime when complexed to double-stranded DNA compared single-stranded DNA. This discovery allows for the quantification of single-stranded DNA in a given sample. This technique, which also incorporates key concepts such as alkaline unwinding buffers and higher unwinding rates of damaged DNA compared to non-damaged DNA, was able to reproducibly measure and differentiate DNA damage from 0--100 Gray of gamma radiation. The results presented include experiments carried out using CT-DNA as well as DNA isolated from sheep white blood cells, suggesting its potential use with isolated DNA from any eukaryotic cell.
How the housing boom has driven rising inequality
Creators: name: Stone, Wendy
name: Ralston, Liss
name: Wiesel, Ilan
Publisher: name: Swinburne
Year: 2024

description: The Productivity Commission – the Australian government’s highly influential economic advisory body – released a report titled Rising Inequality? last week. The question mark indicates its scepticism about other research findings on rising inequality in Australia. The commission responded to its own question in the report’s very first heading: “Over nearly three decades, inequality has risen slightly in Australia”. This conclusion has left commentators divided. Some have celebrated this finding. Others, such as Peter Whiteford and Ross Gittins, argued the true picture is more complex.
An antisymmetric, minimalist approach to Persian phrase structure.
Creators: name: Moinzadeh, Ahmad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Language, Linguistics.

description: In this thesis, I investigate phrase structure in Persian within the Minimalist framework of Chomsky (1995, 1998). Adopting Kayne's (1994) Linear Correspondence Axiom, which examines the relation of hierarchical structure and linear order, I propose a head-initial analysis for Persian, and develop an analysis of SVO word order based on the examination of all lexical and functional categories. Prior to investigating categories which are common to other languages, I examine the Ezafe Phrase (EzP), a functional phrasal category specific to Persian. The EzP is headed by a morpheme which may be phonetically realized as e/ye or null o. This morpheme regulates the occurrence of more than one complement in DPs/NPs and APs. Like the other phrasal categories investigated, the EzP is shown to follow the Spec-Head-Complement configuration (of the Linear Correspondence Axiom). My argumentation for a head-initial configuration for Persian, and the implication of a basic SVO word order is based largely on evidence for noun phrases and verb phrases. I provide support for a DP analysis of Persian nominal phrases, and demonstrate that both DPs and lexical NPs display a head-initial configuration. While Persian VPs exhibit both VO and OV word order in unmarked sentences, I argue that they consistently display a head-initial configuration, an analysis which is theoretically preferable to one based on dual directionality. I support my proposal for a head-initial analysis of VPs and a basic SVO word order in Persian with a variety of empirical evidence about verbal complements, including the exclusive post-verbal generation of CP complements, the placement of clitics, and the position of adverbs relative to verbal heads and their complements. While concentrating on DPs and VPs, I further support my analysis of a head-initial configuration for Persian by examining the Spec-Head-Complement configuration in APs, PPs, IPs and in less detail, the internal structure of CPs and TopPs. On the basis of both theoretical and empirical evidence, I propose a head-initial analysis for all phrasal categories in Persian. In conclusion, I turn to diachronic data which also provides evidence of the Spec-Head-Complement analysis I have proposed for Modern Persian.
L'intégration des personnes handicapées ou voile de l'exclusion.
Creators: name: Burelle, Roxanne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Sociology, General.

description: These examinant le niveau d'integration sociale des personnes vivant avec un handicap physique au sein de la societe canadienne. Le cadre theorique de l'etude s'articule autour de concepts etroitement lies aux ecrits de Pierre Bourdieu et Max Weber soient ceux d'habitus, de reproduction sociale et de situation de classe. On traite, d'une part, des effets chez ce groupe des politiques d'institutionnalisation et, d'autre part, de l'impact de la designation, par les Nations Unies, de l'annee 1981 comme l'Annee internationale des personnes handicapees. Le corps de la these s'organise, dans un deuxieme temps, autour d'un examen des politiques sociales regissant les structures ainsi que des programmes sociaux. On peint ensuite, par le truchement de statistiques a l'appui, un portrait de la population canadienne vivant avec un handicap. Sont ainsi abordes, des themes tels que: l'education, la pauvrete, la violence, les possibilites d'emploi, etc. On conclut la these en signalant l'importance de l'ecart observe a travers l'etude entre la situation socio-economique ideale des Canadiens et Canadiennes qui vivent avec un handicap et celle qui existe reellement en 1990 tout en soulevant les causes sous-jacentes de ce phenomene.
Indigenous and imported primary school textbooks in Belize: A comparative study.
Creators: name: Coates, Martha J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Education, Curriculum and Instruction.

description: The effects of the international knowledge system, the largely political internal mechanisms influencing textbook policy, and the justification of indigenously published textbooks impact on the amount of indigenous content found in textbooks. These issues do not stand alone, isolated from other conflicts and compromises over power and control. The pedagogical decision of imported or indigenous textbooks is framed by the social, historical and political climate. This study examined the differences in indigenous content between imported and indigenously published 'BRC textbooks' used in Belize. BRC language textbooks presented more Belizean culture than Nelson's New West Indian readers. BRC mathematics textbooks presented more practice exercises and fewer new concepts per lesson than CPM textbooks. The BRC textbooks are both a statement of a particular ideological perspective in a political debate over legitimate knowledge, as well as the material expression of a different educational approach and content from that of the MOE. Notably, the BRC struggle is symbolic of the debate over education as a system of reproduction or contestation of legitimate school knowledge.
Investigation into cooperative DNA binding by the Gal4-VP16 transcription factor
Creators: name: Rho, Shinji
Publisher: name: Brandeis University
Year: 2021
Subjects: Gal4-VP16
transcription activator
DNA

description: Gal4-VP16 is an artificial transcription activator with a Gal4 DNA binding domain and aVP16 activation domain, helpful in studying eukaryotic transcription mechanism due to its high
description: transcriptional potency. While numerous papers have shown that Gal4-VP16 has a synergistic effect on transcriptional response when multiple binding sites are present on target DNA, its mechanism of synergy has not been well established. I investigated whether Gal4-VP16 binds cooperatively in vitro, since cooperative binding mechanism may contribute to transcriptional synergy. I expressed and fluorescently labeled a tagged Gal4-VP16 construct designed to have minimal effect on protein function. I then conducted single-molecule experiments with fluorescently labeled Gal4-VP16 to observe activators binding to target DNA molecules with five binding sites. Experimental traces of activator behavior qualitatively agreed with numerical simulation results that modeled independent binding. This suggests that synergy does not arise from cooperative Gal4-VP16 binding, but instead occurs later in the transcription process.
“To begin, at the beginning […]“
Creators: name: Strauch, Annette
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Forschungsdatenmanagement
subject: Universitätsbibliotheken
subject: Schulungen
subject: Research data management
subject: university libraries
subject: training
subject: 020 Bibliotheks- und Informationswissenschaften

description: Der Artikel beschreibt, wie das Forschungsdatenmanagement innovativ in der Universitätsbibliothek Hildesheim umgesetzt worden ist, auch welcher langfristige Nutzen daraus entstanden ist. Ständige Kollaborationen mit den relevanten Akteuren im Forschungsdatenmanagement in der Welt sind dabei präsent. Seit über einem Jahr (Stand: Mai 2020) gibt es Beratungen, Coffee Lectures, Workshops und andere Veranstaltungen, die bei der Umsetzung der neuen digitalen Aufgaben ganz forschungsnah helfen.
description: The article describes how research data management has been carried out innovatively at Hildesheim University Library, and what long-term benefits have resulted from it. Constant collaborations with the relevant players in research data management in the world are present. For over a year (as of May 2020), there have been consultations, coffee lectures, workshops and other events that help to implement the new digital tasks in a research-oriented way.
Will infant hepatitis B vaccination protect into adulthood? Extended Canadian experience after a 2, 4, 6 month immunization schedule
Creators: name: Pinto, Michelle
name: Dawar, Meena
name: Krajden, Mel
name: Naus, Monika
name: Scheifele, David W.
Publisher: name: The University of British Columbia
Year: 2018

description: Introduction: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years afterward in Canadian children. Methods: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at about 2, 4, 6 months of age. Exclusion criteria included prior HBV infection and additional vaccinations. At follow-up anti-HBs testing participants were 10-11 or 15-16 years old; those possibly lacking protection (<12 mIU/mL anti-HBs with assay used) were challenged with HBV vaccine to assess immune memory-based responsiveness. Results: 137 tested participants were 10-11 and 213 were 15-16 years old, respectively; none had evidence of prior HBV infection. At baseline, 78.1% of younger and 64.3% of older participants had <12 mIU/mL anti-HBs (p=0.006) and were challenged with vaccine: 103/106 (97.2%) younger and 123/135 (91.1%) older participants developed ≥12 mIU/mL anti-HBs (p=0.06), with GMC of 590 (95%CI 473, 737) and 319 mIU/mL (95% CI 229, 445)(p=0.004), respectively. Immune memory loss may have occurred in 3 younger (2.2%) and 12 older children (5.6%) (p=0.06) who were non-responsive to first but not second vaccine challenge. Conclusions: After HBV vaccination at 2, 4, 6 months of age, most adolescents had little or no residual antibody but nearly all responded to HBV challenge, confirming immune memory persistence. However, anamnestic responses were weaker in 15-16 year olds and lost in some. Booster responses in 10-11 year olds were vigorous in comparison. Extended evaluation of protection is warranted.
Engagement in Leisure Activities Predicts the Inflammatory Response to Acute Psychosocial Stress
Creators: name: Hanlin, Luke
Publisher: name: Brandeis University
Year: 2012
Subjects: CVD
TSST
IL-6
Inflammation
Stress

description: Cardiovascular disease has become the leading cause of death in the developed world. Increasingly inflammation is being targeted as a contributor driving the progression of these diseases and is directly implicated in the development of atherosclerosis. The type of persistent chronic inflammation associated with CVD is the result of maladaptive stress responses. Behaviors and states that have an effect on this response, beyond traditional risk factors, are coming under increasing attention as potential means to mediate the pathogenesis of CVD. Of these, engagement in leisure activities is a novel and strong candidate. As such, this investigation was conducted to test the hypothesis that individuals who reported engaging in more leisure activities would experience a lower inflammatory response to a psychosocial stressor.\r A sample of n=18 young adults were screened to be healthy and exposed to the Trier Social Stress Test (TSST). Participants (14 male; 8 Caucasian) had a mean age of 21.86 years (SD=4.30) and a mean BMI of 24.28 kg/m2 (SD=3.62). Inflammation, is indicated by Interleukin-6 (IL-6), was measured at baseline just before the TSST as well as 30 and 120 minutes after stress exposure. Leisure Engagement was assessed using the Pittsburgh Enjoyable Activities Test (PEAT).\r As shown in Figure 1, IL-6 concentrations increased over time with highest levels two hours after stress exposure revealing a significant time effect (F1.095=18.27; p=0.003). To test whether self-reported leisure activities were related with IL-6 responses to stress, we computed a repeated measures ANCOVA including PEAT as a covariate. Results revealed a significant time by PEAT interaction (F1.12,17.92=4.42; p=0.046). To confirm this relationship and test for directionality, we tested for bivariate correlations between PEAT and the change in IL-6 as a measure of the IL-6 response to stress. As shown in Figure 2 there was a significant inverse correlation, with higher self-reported leisure activity predicting lower IL-6 stress responses (r=-0.49; p=0.040).
Osteoclast-Driven Polydopamine-to-Dopamine Release: An Upgrade Patch for Polydopamine-Functionalized Tissue Engineering Scaffolds
Creators: name: Ko, Ching-Chang
name: Hu, Huamin
name: Wang, Lufei
Publisher: name: MDPI
Year: 2024

description: Polydopamine, a mussel-inspired self-adherent polymer of dopamine, has impressive adhesive properties and thus is one of the most versatile approaches to functionalize tissue engineering scaffolds. To date, many types of polydopamine-functionalized scaffolds have been manufactured and extensively applied in bone tissue engineering at the preclinical stage. However, how polydopamine is biodegraded and metabolized during the bone healing process and the side effects of its metabolite remain largely unknown. These issues are often neglected in the modern manufacture of polydopamine-functionalized materials and restrict them from stepping forward to clinical applications. In this study, using our bioinspired polydopamine-laced hydroxyapatite collagen calcium silicate material as a representative of polydopamine-functionalized tissue engineering scaffolds, we discovered that polydopamine can be metabolized to dopamine specifically by osteoclasts, which we termed “osteoclast-driven polydopamine-to-dopamine release”. The released dopamine showed an osteoinductive effect in vitro and promoted bone regeneration in calvarial critical-sized defects. The concept of “osteoclast-driven polydopamine-to-dopamine release” has considerable application potential. It could be easily adopted by other existing polydopamine-functionalized scaffolds: just by recruiting osteoclasts. Once adopted, scaffolds will obtain a dopamine-releasing function, which enables their modulation of osteoblast activity and hence elevates the osteoinductive effect. Thus, “osteoclast-driven polydopamine-to-dopamine release” serves as an upgrade patch, which is useful for many existing polydopamine-functionalized materials.
Investigating factors that influence cognitive response to, and the efficacy of, cognitive remediation therapy in people with schizophrenia
Creators: name: Reser, Maree
Publisher: name: Swinburne
Year: 2024

description: A majority of individuals diagnosed with schizophrenia experience cognitive difficulties, which are, in turn, a strong predictor of future persisting disability. Cognitive remediation therapy is moderately effective in strengthening cognitive skills, however not everyone realises a cognitive benefit. The overarching goal of this thesis was to arrive at a better understanding of factors that influence individual response to, and the efficacy of, cognitive remediation therapy in people diagnosed with schizophrenia. By providing greater transparency of factors that influence outcome, the research outcomes have the potential to inform clinical treatment planning and practice, optimising the likelihood of a positive treatment response.
Report - COVID-19 Crisis & Emergency Practices - Infusion Pumps in ICU: THE ROLE OF METROLOGY
Creators: name: Batista, Elsa
name: Metaxiotou, Zoe
name: Emmelyn Graham
name: Annemoon Timmerman
name: Furtado, Andreia
name: Lotters, Joost
name: Silvério, Vania
Publisher: name: Zenodo
Year: 2020
Subjects: Traceability, caibration, drug delivery devices, covid-19

description: This report was produced as a deliverable outlined in the Exploitation Plan, covering a case study from the EMPIR Metrology for Drug Delivery (MeDD II) project in order to help hospital administrations to develop best practises and guidelines for new COVID-19 drug delivery measures.
The Expressive Message of Welfare Conditionality: How Work Requirements Devalue Welfare Recipients
Creators: name: Ben-Gideon, Vered Shulamit
Publisher: name: Brandeis University
Year: 2024
Subjects: subject: Economics
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Public Policy

description: This thesis discusses the history of work requirements as a policy tool. I discuss arguments for an against these requirements before posing a new argument about the harm of this policy tool.
Oxidation of rare earth permanent magnets
Creators: name: Firdaus, Muhamad
Publisher: name: Swinburne
Year: 2024

description: Recovering the rare earth elements namely Neodymium, Praseodymium and Dysprosium from End of Life permanent magnets are becoming increasingly important. This research investigate the behavior of these magnets in the high temperature oxidation in recycling process. The research provide important information on microstructural evolution and kinetic analysis at high temperature 773-1573 K (500-1300 °C) and revealed that oxidation of the End of Life magnets highly influenced the recovery rate of different high temperature recycling/recovery techniques. The study also highlighted the formation of rare earth ortho-ferrites and proposed a process to recover rare earth after oxidation in air.
Note Illustrative della Carta geologica d'Italia alla scala 1:50.000, F. 301 Fabriano
Creators: name: Chiocchini, U.
name: Centamore, E.
name: Micarelli, A.
name: Giardini, G.
name: Jacobacci, A.
name: Dramis, F.
name: Chiocchini, M.
name: Martelli, G.
name: Potetti, M.
Publisher: name: sdalpra
Year: 1979

description: Note illustrative redatte per il Foglio geologico n. 301 Fabriano della Carta Geologica d'Italia alla scala 1:50.000. 28 pp.
Understanding the Impact of the Price of Carbon on Emissions Reduction: Studying the Efficiency of Allocation of Emissions Permits in Sweden and Denmark
Creators: name: Macharla, Sahithi
Publisher: name: Brandeis University
Year: 2023
Subjects: Emission Control
Energy Planning or Policy

description: This paper aims to understand the impact of participating in the EU ETS on the emissions of  Sweden and Denmark by studying the performance of industries with different marginal costs  to abate under different policy scenarios. To do so, I construct a partial equilibrium model of  allocating available permits using linear programming across different policy scenarios in  Denmark and Sweden to understand both reductions in emissions caused due to carbon  pricing policies and the evolution of the cost to emit for these industries. In particular, I use  the cost of energy as a proxy for the cost to emit (or abate) to understand whether industries  with a lower cost to emit, either due to a reliance on cheaper energy sources or carbon neutral fuels, are rewarded and whether this system leads to a reduction in the rate of  emissions per unit output. 
Fermentation and formulation of growth enhancing microorganisms as biofertilizer for a timber tree species, Eucalyptus pellita
Creators: name: Kiat, Stanley Ho Han
Publisher: name: Swinburne
Year: 2024

description: Usage of chemical fertilizers is a common practice in the agricultural field and has increased rapidly throughout the years. This consequently resulted in environmental pollution. As such, biofertilizers containing plant growth promoting microbes (PGPR) are introduced. In this study, the effectiveness of the microorganisms in the biofertilizer formulation was tested by conducting pot trial and field trial. Studies showed that the combination of biofertilizer and 50% chemical fertilizer could enhance the growth of Eucalyptus pellita as effective as the 100% chemical fertilizer.
Analysis and cancellation of inter-carrier interference for OFDM systems over time-variant multipath fading channels.
Creators: name: Zhang, Yunjun.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Engineering, Electronics and Electrical.

description: The orthogonality among the subcarriers of OFDM systems may be impaired by the time-selectivity of the fading channels. The loss of the orthogonality results in ICI, and if it is not treated appropriately, the system performance may not be improved only by increasing the signal-to-noise ratio. In other words, ICI results in error floors. This research work concentrates on the ICI analysis and cancellation, and also on the effects of channel time-selectivity on the OFDM systems over frequency-selective time-variant mobile fading channels. In the first part of this study, a general time-variant frequency-selective WSSUS fading channel model is further characterized to support the OFDM ICI analysis, thus the obtained results are applicable for many specific channels. We then identify the cause of the ICI, i.e. how the orthogonality among the subcarriers of OFDM systems is impaired. The average ICI power and its distribution are obtained based on the general time-variant frequency-selective WSSUS fading channel model. To mitigate the ICI caused by the channel time-selectivity for OFDM systems, in the second part of this study, an efficient ICI cancellation scheme is designed based on the obtained ICI power distribution. The simulation results indicate that a significant performance improvement can be achieved. For OFDM systems, differential encoding can be performed not only between the information bits of the same subcarrier of the consecutive OFDM symbols (inter-frame differential encoding), but also between the information bits of the adjacent subcarriers of the same OFDM symbol (inter-carrier differential encoding). In the third part of this study, we compare the performance of inter-frame and inter-carrier differential detection for OFDM systems over multipath time-variant mobile fading channels. The objective is to identify which differential encoding scheme (inter-frame or inter-carrier) is more robust to the channel time-selectivity, when OFDM systems are experiencing both frequency-selective and time-selective fading. The conditions under which the inter-carrier differential encoding outperforms the inter-frame differential encoding and vice-versa are provided.
Making Tourism a Viable Economic Solution for Cape Verde
Creators: name: Lima, Aeisha
Publisher: name: Brandeis University
Year: 2013
Subjects: subject: remittances
subject: neoliberal
subject: global studies
subject: Cape Verde
subject: Tourism
subject: FOS: Economics and business

description: In the pre and post-independence era, high levels of migration and the resulting remittances were responsible for circulating capital in the local markets of Cape Verde, a country nearly devoid of natural resources. Over the last two decades, stricter immigration policies in destination countries, in tandem with the importation of cheap labor from out of the country has dried up the capital inflow in the poor local markets. Travel, however, still seems to be a relevant economic solution for Cape Verde, albeit in a different form than it has historically been. Rather than exporting labor for the sake of remittances from overseas, Cape Verde has slowly begun to increase its desirability as a mainstay in the tourism market. By creating a steady flow of capital into the tourism industry, and returning the services relevant to this industry to local entrepreneurs in local markets, Cape Verde can reestablish the flow of capital from foreign economies which has historically driven their local money supply. This thesis discusses what the government has done to grow the economy. The Cape Verdean government has adopted neo liberalism as an approach to development. Cape Verde is procuring development aid from international institutions such as the World Bank, International Monetary Fund, the\r United States, and the European Union, which advocate free market policies that are based on the theory of neo-liberalism. This paper examines some of the neo-liberal policies that the government has embraced in order to industrialize the economy, create jobs, and to increase the standard of living.
Supererogation, imperfect duty and the structure of moral action.
Creators: name: Scott, Jon J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Philosophy.

description: Traditionally, philosophers have recognized three types of moral actions: the obligatory, the permissible and the prohibited. But this classification cannot account for acts of saintliness or heroism--or indeed of any self-denying good actions which are not obligatory to perform. These actions are termed supererogatory--they are more than duty requires and are accompanied by some specific features, notably that they are done in the interests of others than the moral agent and that they involve costs or risks. If supererogatory acts are accepted as a category of moral action, then the traditional tripartite classification needs to be revised: the categories of obligatory and permissible acts are redistributed in terms of duties, morally neutral actions, offenses, and acts of supererogation. Morally neutral actions are rejected as a separate category of moral value. Duties are divided into those which can be legitimately enforced (imperfect duties) and those which cannot be matched by rights (imperfect duties). Justice involves both types of rights and duties. An account of the full spectrum of moral action recognizes internal and external aspects and justifies the use of aretaic and deontic methods. It includes five types of moral actions: prohibited acts, offenses, perfect duties, imperfect duties and acts of supererogation. This account is relevant to the facts of moral experience. It is compatible with the major theoretical frameworks in ethics, and it is formulable in terms of manageable complexity.
Water, equity and resilience in Southern Africa : future directions for research and practice
Creators: name: Rodina, Lucy
name: Baker, Lawrence A.
name: Galvin, Mary
name: Goldin, Jaqueline
name: Harris, Leila
name: Manungufala, Thomani
name: Musemwa, Muchaparara
name: Sutherland, Catherine
name: Ziervogel, Gina, 1975-
Publisher: name: The University of British Columbia
Year: 2019

description: Drawing from the proceedings of an expert workshop with academics, researchers, government and NGO participants working in diverse countries in southern Africa and beyond, this paper reviews the discourse on resilience, both conceptually and in practice. We highlight opportunities to develop and apply more situated, equity-sensitive and context-relevant understanding of resilience, particularly in the water sector. To pursue more just and resilient water futures in highly unequal and water stressed regions, we propose that researchers and practitioners (1) place greater emphasis on the transformative potential of resilience, (2) broaden the social dimensions of resilience to account more fully for intangible and other social factors, (3) engage critically with the decision-making processes and practices of building resilience, (4) contribute to the development of indicators and guidelines for building just and resilient water futures, (5) strengthen the role of situated knowledges, (6) critically engage with scale and boundaries in complex adaptive systems, and (7) strengthen the policy-science-civil society interface.
Translation and visual communication: Case study of a hospital information leaflet.
Creators: name: St-Jean, Ewa.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Language, Modern.

description: The purpose of this study is to explain and demonstrate that, in the leaflet--as a specific form of discourse-- meaning is primarily a product of the textual interrelationship of both its verbal and visual components. Our definition of meaning of the message in this analysis is that of form-meaning. The object of our analysis is a particular genre of discourse--the leaflet--which is placed at the intersection of verbal and visual communication. We begin by looking at visual communication theory to better understand how meaning is produced in "visual discourse". Next, we proceed to trace the way translation theory deals with the notion of "form" with regard to meaning. Finally, based on a case study of a hospital informlation leaflet we clearly demonstrate that there is an "isotopic" relationship between meaning and textual form. Ultimately, our study will reveal the necessity to reconsider the notion of "form" as it applies to pragmatic texts in translation theory and didactics. (Abstract shortened by UMI.)
"Yesterday, today, and forever": The mythic foundations of the Ku Klux Klan in the United States and Canada
Creators: name: Bryant, Andrew M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Religion, General.
subject: Religion, History of.
subject: History, Canadian.
subject: History, United States.

description: The Ku Klux Klan has been active in North America for 139 years and organizations like the Klan have existed in North America since before the United States and Canada became independent nations. The white supremacy advocated by the Klan mimics the justifications used by colonial powers, and though the United States and Canada have espoused egalitarian ideals for quite some time, the Klan continues to attract members. Mircea Eliade and Claude Levi-Strauss have argued that history and myth share many characteristics, and that sometimes history can act as myth. Understanding how North American history can be a mythic model for the religious formation of North American people one can better explain the long-term viability of the Klan and its ability not only to inspire violence, but to articulate a particular kind of white North American identity. This study examines how the religiosity and action of the Klan has been informed by mytho-historical influences in the United States and Canada and, consequently, how these influences affect other people formed in this context.
title: Deletions, Inversions, Duplications
title: Engineering of Structural Variants using CRISPR/Cas in Mice
titleType: Subtitle
Creators: name: Kraft, Katerina
name: Geuer, Sinje
name: Will, Anja J.
name: Chan, Wing Lee
name: Paliou, Christina
name: Borschiwer, Marina
name: Spielmann, Malte
name: Mundlos, Stefan
name: Lupiáñez, Darío G.
name: Andrey, Guillaume
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Structural variations (SVs) contribute to the variability of our genome and are often associated with disease. Their study in model systems was hampered until now by labor-intensive genetic targeting procedures and multiple mouse crossing steps. Here we present the use of CRISPR/Cas for the fast (10 weeks) and efficient generation of SVs in mice. We specifically produced deletions, inversions, and also duplications at six different genomic loci ranging from 1.1 kb to 1.6 Mb with efficiencies up to 42%. After PCR-based selection, clones were successfully used to create mice via aggregation. To test the practicability of the method, we reproduced a human 500 kb disease-associated deletion and were able to recapitulate the human phenotype in mice. Furthermore, we evaluated the regulatory potential of a large genomic interval by deleting a 1.5 Mb fragment. The method presented permits rapid in vivo modeling of genomic rearrangements.
La pornographie dans les bars homosexuels masculins: Une étude exploratoire
Creators: name: Corneau, Simon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Sociology, Criminology and Penology.

description: Deux perspectives dominent le sujet de la pornographie homosexuelle masculine dans la littérature. La première, dite pro féministe, voit la pornographie homosexuelle comme outil de renforcement du masculin et de subordination des homosexuels. La deuxième perspective, utilitariste, lit la pornographie homosexuelle masculine comme un outil essentiel pour la libération politique des homosexuels, comme moyen d'éducation quant aux pratiques sexuelles sécuritaires et comme moyen de valider une sexualité longtemps maintenue sous le joug de l'interdit. Ce qui surprend à la vue de tous ces arguments autour de l'objet est le manque quasi-total d'étude empirique pour soutenir de tels discours. Cette recherche de nature exploratoire a comme mandat de dégager la signification que les clients donnent face à la diffusion de matériel pornographique vidéo dans certains bars homosexuels de deux grandes villes de l'est du Canada. Le peu qui existe à l'intérieur de la littérature sur les bars homosexuels met l'accent sur leur importance en termes de socialisation, comme lieu social sécuritaire et protégé et finalement comme espace propice à l'exploration sexuelle. Nous utilisons pour cette recherche la méthode de l'entretien semi-dirige avec des acteurs clés du milieu (4 sujets) et des clients réguliers (7 sujets). La méthode de la théorisation ancrée est utilisée afin de dégager les thèmes récurrents. L'analyse, utilisant un cadre interactionniste symbolique, nous permet de nous sortir des deux perspectives dominantes et ainsi mettre en lumière le fait que la pornographie présentée en contexte de sociabilité peut servir a créer une ambiance sexuelle, favorisant ainsi la rencontre et les activités sexuelles à l'intérieur même de l'espace social protégé que sont les bars homosexuels masculins.
Targeting of adenovirus serotype 5 infectivity to EGFRvIII-expressing cells using a bispecific CAR-scFv.
Creators: name: Kottachchi, Dayantha.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Chemistry, Biochemistry.

description: A mutant form of the Epidermal Growth Factor Receptor (EGFR), known as EGFR version III, is over-expressed exclusively on various forms of cancer cells. MR1, a single chain antibody variable domain fragment (scFv), is able to bind with high affinity and specificity to EGFRvIII and not to the wild-type receptor. The purpose of this study was to investigate a possible means of developing an adenoviral vector (based on subclass C viruses) that can utilize MR1's targeting ability towards EGFRvIII to infect only cancer cells that express this receptor. Adenovirus infectivity is primarily mediated by binding of the globular carboxyl terminus of its fiber protein, known as the knob domain, to the coxsackievirus and adenovirus receptor (CAR), which is expressed on various cell types. Although we attempted three different approaches to try and target the virus using MR1, including direct incorporation of the scFv into the knob domain of adenovirus, it was the creation of a fusion protein consisting of the extracellular domain of CAR linked to MR1 that suggested increased infectivity to EGFRvIII expressing cells. According to ELISA analysis, the CAR/MR1 fusion protein is able to retain the two independent binding affinities of its composite subunits (bispecificity) as strongly as the two independent proteins do for the knob domain and EGFRvIII, respectively. Additionally, a U87MG EGFRvIII transduced cell line, as opposed to its parental U87MG cell line, showed increased infectivity by adenovirus when incubated with CAR/MR1. These findings suggest that CAR/MR1 is able to bind to and re-direct infection of adenovirus to EGFRvIII expressing cells.
The prevalence of medication-related problems in kidney transplant recipients at a tertiary care hospital in Saudi Arabia
Creators: name: Ismail, Sherin
name: Aseeri, Mohammed
name: Hasan, Hani
name: Alsubhi, Abrar
name: Katlan, Danyah
Publisher: name: Springer Nature
Year: 2024

description: Background Limited data are available regarding the prevalence of medication-related problems (MRPs) in kidney transplant recipients. This study aimed to determine the prevalence and types of medication-related problems. Methods A cross-sectional study was conducted including kidney transplant recipients aged ≥ 18 years who were receiving immunosuppressive agents for at least 3 months post-transplant. The primary outcome was to determine the prevalence of MRPs. The secondary outcomes were to identify the pharmacological classes, categories of medications contributing to MRPs, and predictors of developing > 3 MRPs. Results We enrolled 107 kidney transplant recipients. The mean ± standard deviation (SD) of age and body mass index (BMI) were 50 ± 15.8 years and 28.9 ± 5.3 (kg/m2), respectively, and 66.3% were male. The prevalence of MRPs was 28.97% [95% confidence intervals (CI) 19.68%, 41.125] in 1393 prescriptions. The frequent types of MRPs were drug‒drug interactions (46.1%), duplication (12%), and medication use without an indication (11.7%). Immunosuppressive agents and cardiac medications were the main classes causing MRPs. The number of medications and the years post-kidney-transplant were significant predictors of developing > 3 MRPs. Conclusion The results showed that drug‒drug interactions were the most frequent MRPs, with immunosuppressive agents being the most common class causing MRPs.
Duality of magmatism at Kirkland Lake, Ontario, Canada.
Creators: name: Levesque, Guy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Geology.

description: One of the world's most productive gold camps is located along the major east-trending Larder Lake fault (LLF), which extends approximately 250km from Val d'Or to Kirkland Lake. The western portion of the LLF consists of a 60 km long narrow (less than 5 km wide) and sinuous deformation zone commonly referred to as the Kirkland Lake-Larder Lake fault zone (KLF). The occurence of two distinct suites of magmatic rocks, syenitic and granitic, in and around the KLF indicates a magmatic duality. It is possible to identify three distinct magmatic domains defined by mode of emplacement, minerology and geochemistry. Mineral chemistry indicates that rocks from both suites evolved under oxidizing conditions in domains 1 and 3. Rare earth element compositions indicate a similar upper mantle source for both magmatic suites. Major element compositions confirm the shoshonitic nature of the syenitic suite, while the granitic suite is comparable to the sanukitoid suite (high-Mg,-K, -LILE andesites). Both the syenitic and granitic suites originate from an upper mantle source that was very probably modified a relatively short time before by fluids and/or melts derived from a subducted slab. The Kirkland Lake area is marked by an early transtensive phase when syenitic and granitic rocks were emplaced in extensional fractures associated to sinistral strike-slip faulting. Uplift of domain 3 and reverse faulting along the Kirkland Lake main break (KLMB) and the LLF are associated with a later transpressive phase; it was during this phase that gold deposits were formed. The structural, mineralogical and geochemical evidence fit in a tectomagmatic model where oblique convergence and accretion dominate.
Spectral Richness and Comprehension of Spoken Discourse: A Vocoder Simulation of Cochlear Implant Hearing
Creators: name: Dinnar, Shai
Publisher: name: Brandeis University
Year: 2023
Subjects: cochlear implant
Neuroscience

description: Spoken discourse in cochlear implant users is complex due to the perceptual and cognitive challenges associated with processing degraded signals. In this thesis I hypothesized that success in comprehension and memory for discourse should extend beyond solely accuracy but also should address the fatigue from effortful processing of extended discourse. I argue that one should define successful discourse processing as accuracy achieved with minimal effort. In this study, younger and older adults with normal (acoustic) hearing were tested for recall of speech passages using channel vocoding to simulate the sounds delivered by cochlear implants. Participants heard recorded speech passages interrupted at clause and sentence boundaries to allow them to self-pace through a passage. Passages were vocoded to 4 channel, 8 channel, 16 channel, and unprocessed speech. Recall accuracy and effort ratings showed that even as performance accuracy reached an asymptote, for both younger and older adults self-rated effort continued to decline as speech became clearer with more vocoder channels. The analysis of pause durations at sentence and clause boundaries reflected listeners taking time to absorb new information at the beginning of a passage, followed by faster pacing near the end of the passage as the integration of new details about the topic became easier. The vocoder simulations represented in this thesis argue for the clinical evaluation of cochlear implant success to move beyond tests of intelligibility for simple speech materials, and to introduce a definition of success that includes the effort needed to attain this success.
3032388.pdf
Creators: name: Godet, Adrien
name: Ndao, Abdoulaye
name: Sylvestre, Thibaut
name: pecheur, vincent
name: Lebrun, Sylvie
name: Pauliat, Gilles
name: Beugnot, Jean Charles
name: Huy, Kien Phan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary material
3032388.pdf
Creators: name: Godet, Adrien
name: Ndao, Abdoulaye
name: Sylvestre, Thibaut
name: pecheur, vincent
name: Lebrun, Sylvie
name: Pauliat, Gilles
name: Beugnot, Jean Charles
name: Huy, Kien Phan
Publisher: name: Optica Publishing Group
Year: 2017
Subjects: Uncategorized

description: Supplementary material
STI Knowledge in Berlin Adolescents
Creators: name: Rosen, Frederik Tilmann Von
name: Rosen, Antonella Juline Von
name: Müller-Riemenschneider, Falk
name: Damberg, Inken
name: Tinnemann, Peter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: sexual health
subject: sexually transmitted diseases
subject: sexually transmitted infections
subject: adolescent health
subject: Berlin
subject: Germany
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::614 Inzidenz und Prävention von Krankheiten

description: Sexually transmitted infections (STIs) pose a significant threat to individual and public health. They disproportionately affect adolescents and young adults. In a cross-sectional study, we assessed self-rated and factual STI knowledge in a sample of 9th graders in 13 secondary schools in Berlin, Germany. Differences by age, gender, migrant background, and school type were quantified using bivariate and multivariable analyses. A total of 1177 students in 61 classes participated. The mean age was 14.6 (SD = 0.7), 47.5% were female, and 52.9% had at least one immigrant parent. Knowledge of human immunodeficiency virus (HIV) was widespread, but other STIs were less known. For example, 46.2% had never heard of chlamydia, 10.8% knew of the HPV vaccination, and only 2.2% were aware that no cure exists for HPV infection. While boys were more likely to describe their knowledge as good, there was no general gender superiority in factual knowledge. Children of immigrants and students in the least academic schools had lower knowledge overall. Our results show that despite their particular risk to contract an STI, adolescents suffer from suboptimal levels of knowledge on STIs beyond HIV. Urgent efforts needed to improve adolescent STI knowledge in order to improve the uptake of primary and secondary prevention.