cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of cytokines in alveolar macrophage differentiation.
Creators: name: Yang, Huixin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Cell.

description: The effects of macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) on rat alveolar macrophage (AM) differentiation in vitro were investigated in this study. Both M-CSF and GM-CSF triggered AM differentiation and multinucleated giant cell (MGC) formation. Morphological analysis further demonstrated that there were two distinct variants of MGC. Type 1 MGC normally contained 3 to 8 nuclei and appeared as a large round cell and type 2 MGC contained a higher number of nuclei (up to 30) and displayed irregular, elongated shapes. We also observed that a greater proportion of type 2 MGC expressed $\beta\sb3$ integrin, thus bringing additional evidence for differences between type 1 and type 2 MGC. Assessment of the relative proportion of type 1 and type 2 MGC indicated that M-CSF induced the formation of both types of MGC to a similar extent and GM-CSF induced predominantly the formation of type 2 MGC. Experiments with anti-M-CSF or anti-GM-CSF antibody to neutralize and cross-block the effects of M-CSF and GM-CSF further confirmed that M-CSF is associated with type 1 MGC formation whereas GM-CSF is responsible for type 2 MGC formation. Type 2 MGC seen in M-CSF treated groups may result from endogenous production of GM-CSF induced by M-CSF. This is supported by RT-PCR experiments in which M-CSF was shown to stimulate GM-CSF mRNA expression. Molecular phenotyping of a set of cytokines known to participate in inflammation and AM regulation was performed using RT-PCR at various times (up to 5 days) of AM differentiation. AM freshly obtained by BAL (0 time) did not show mRNA expression of TNF-$\alpha,$ IL-1$\alpha$ and IL-6, indicating these proinflammatory cytokines are not constitutively expressed by rat AM. Compared to the controls, both M-CSF and GM-CSF increased mRNA expression of TNF-$\alpha$ and IL-1$\alpha,$ suggesting these 2 cytokines are involved in M-CSF or GM-CSF induced AM differentiation. A significant increase of IL-6 mRNA expression was observed only in GM-CSF treated groups and the expression appeared early and persistently at all time points studied. Experiments with exogenous IL-6 and antibody to IL-6 receptor further indicated that IL-6 is involved in type 2 MGC formation. TGF-$\beta$ mRNA was constitutively expressed by rat AM and further enhanced by M-CSF and GM-CSF. Results from exogenous TGF-$\beta$ suggested that this cytokine favors formation of type 1 MGC over type 2 MGC. Cytoplasmic expression of TNF-$\alpha,$ PDGF and TGF-$\beta$ was investigated using immunocytochemical procedures. MGC were found to be able to express these cytokines, suggesting that MGC are a functional population rather than merely dead-end cells. Interestingly, type 1 MGC always showed higher levels of these cytokines than type 2 MGC, suggesting that type 1 MGC may be functionally more active than type 2 MGC.
title: Die ankylosierende Spondylitis besser verstehen – „Begreifen“ von Pathologien am Achsenskelett mittels hochauflösendem 3D Prototyping
Creators: name: Kleyer, Arnd
name: Pachowsky, Milena
name: Schuster, Louis
name: Steiger, Florian
name: Knitza, Johannes
name: Bayat, Sara
name: Schett, Georg
name: Simon, David
name: Hueber, Axel
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In der studentischen Lehre spielt das Fachgebiet der Rheumatologie eine zu kleine Rolle [ref:1]. Deshalb werden Werkzeuge benötigt, um das Fach Rheumatologie den Studierenden „begreifbar“ zu machen und damit Nachwuchs für die fachärztliche Ausbildung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Acute effects of active breaks during prolonged sitting on subcutaneous adipose tissue gene expression: an ancillary analysis of a randomised controlled trial
Creators: name: Grace, Megan S.
name: Formosa, Melissa F.
name: Bozaoglu, Kiymet
name: Bergouignan, Audrey
name: Brozynska, Marta
name: Carey, Andrew L.
name: Veiga, Camilla Bertuzzo
name: Sethi, Parneet
name: Dillon, Francis
name: Bertovic, David A.
name: Inouye, Michael
name: Owen, Neville
name: Dunstan, David W.
name: Kingwell, Bronwyn A.
Publisher: name: Swinburne
Year: 2024

description: Active breaks in prolonged sitting has beneficial impacts on cardiometabolic risk biomarkers. The molecular mechanisms include regulation of skeletal muscle gene and protein expression controlling metabolic, inflammatory and cell development pathways. An active communication network exists between adipose and muscle tissue, but the effect of active breaks in prolonged sitting on adipose tissue have not been investigated. This study characterized the acute transcriptional events induced in adipose tissue by regular active breaks during prolonged sitting. We studied 8 overweight/obese adults participating in an acute randomized three-intervention crossover trial. Interventions were performed in the postprandial state and included: (i) prolonged uninterrupted sitting; or prolonged sitting interrupted with 2-minute bouts of (ii) light- or (iii) moderate-intensity treadmill walking every 20 minutes. Subcutaneous adipose tissue biopsies were obtained after each condition. Microarrays identified 36 differentially expressed genes between the three conditions (fold change ≥0.5 in either direction; p < 0.05). Pathway analysis indicated that breaking up of prolonged sitting led to differential regulation of adipose tissue metabolic networks and inflammatory pathways, increased insulin signaling, modulation of adipocyte cell cycle, and facilitated cross-talk between adipose tissue and other organs. This study provides preliminary insight into the adipose tissue regulatory systems that may contribute to the physiological effects of interrupting prolonged sitting.
title: Welche Faktoren determinieren den radiologischen Verlauf der Psoriasisarthritis?
Creators: name: Pfeil, Alexander
name: Heinz, Marcus
name: Renz, Diane
name: Böttcher, Joachim
name: Wolf, Gunter
name: Oelzner, Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Psoriasis Arthritis (PsA) ist mit osteodestruktiven und osteoproliferativen Veränderungen des Hand- und Fußskelettes verbunden. Eine Bestimmung der Knochenmineraldichte an den Metakarpalknochen ist durch die Digitale Radiogrammetrie (DXR) und die Quantifizierung der Fingergelenkspaltweite[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Die Rheuma-VOR App: Optimierung der Frühdiagnose von rheumatischen Erkrankungen – Ein Update
Creators: name: Dreher, Matthias
name: Wojnowski, Leszek
name: Tibyampansha, Dativa
name: Schwarting, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Im Zuge von Rheuma-VOR wurde eine Smartphone App entwickelt, um vor allem Primärversorger bei einer möglichen Verdachtsdiagnostik zu unterstützen. Zusätzlich wurde ein Nachschlagewerk erstellt, um den ärztlichen Nutzer additive Informationen zu den drei Erkrankungsbildern[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Supplementary document for Direct Comparison with Terahertz Metamaterials and Surface-Enhanced Raman Scattering in Molecular-Specific Sensing Performance - 4986703.pdf
Creators: name: Lee, Soohyun
name: Roh, Yeeun
name: Lee, Sang-Hun
name: Ryu, Yong-Sang
name: Ju, Byeong-Kwon
name: Seo, Minah
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Computer Vision Analysis & Monitoring of Vegetation Control Operations on Indiana Roadsides
Creators: name: Wiegman, Timothy J.
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 400904
subject: Electronic device and system performance evaluation, testing and simulation
classificationCode: 400905
subject: Electronic instrumentation
classificationCode: 409901
subject: Agricultural engineering
classificationCode: 409902
subject: Engineering instrumentation

description: Roadside vegetation control is an important part of modern infrastructure maintenance. Little data has been published to characterize the modern roadside mowing environment, identify challenges encountered by mowers, or quantify mower behaviors and responses to encountered conditions. A robust and effective methodology for collecting such information is also not rigorously defined in the literature. A better understanding of these factors, and more sophisticated tools with which to analyze them, may allow improving the efficiency, safety, and sustainability of the mowing process. In this document, it is shown that programmable action-sports cameras and standard agricultural telematics loggers can be used to record useful data about roadside mowing operations for understanding current operations and informing future developments. Image classification models detect human-operated mower incidents in the data gathered with the demonstrated equipment with rates of obstacle contact at up to 8 times per hour and of causing permanent damage to obstacles at up to 0.4 times per hour. The same model also shows human-operated mowers spend up to 60% of mowing time contacting road shoulders or lane surfaces on divided highways and up to 90% for rural roads. A visual odometry model was also tested on the gathered data to estimate tractor movement speed, but results from that model were inconclusive. The quantitative results reported here may enable future development of novel roadside vegetation control technologies, such as autonomous mowers or more advanced driver-assist systems for roadside tractor operations.
Emotional intelligence and propensity to be a teamplayer
Creators: name: Ilarda, Elisa
name: Findlay, Bruce M.
Publisher: name: Swinburne
Year: 2024

description: The present study is one of the first to investigate the role of emotional intelligence in the predilection for teamwork. One hundred and thirty-four respondents, all working in teams, were administered Palmer and Stough’s (2001) measure of emotional intelligence, the NEO-FFI and the Team Player Inventory (Kline, 1999). In line with expectations, the strongest correlations with teamwork were found to be with extraversion, total emotional intelligence and agreeableness. Neuroticism correlated negatively with teamwork and no relationship was found between conscientiousness and predilection for teamwork. Additionally, this research challenged the argument that emotional intelligence is little more than personality by showing that the construct of emotional intelligence added predictive power to that of personality. Limitations and implications for future research are also discussed.
title: Tumoraciones intranasales: correlación radio-patológica
Creators: name: Hernandez Caler, Rocio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Head and neck

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
- Descripción de los hallazgos por imagen de las tumoraciones en fosas nasales recogidos en nuestro centro. - Describir los distintos subtipos histológicos y su correlación...
Isotope hydrogeology and aqueous geochemistry of selected British Columbia hotsprings.
Creators: name: Phillips, Robert John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Geology.

description: Hydrogeochemical analyses of the thermal waters at Hotsprings Cove, west coast Vancouver Island, reveal the presence of a stable geothermal reservoir. Temperature (50.5$\sp\circ$C), and aqueous geochemical data are nearly identical to those dating back to 1898. $\delta\sp $O-D plots indicate local recharge for these thermal waters, whereas radiocarbon isotopes suggest mean residence times of several thousand years and modification by sulphate-reducing bacteria. Bromide/chloride ratios, when considered with tritium and $\sp{34}$S data, are indicative of minor seawater mixing near the discharge zone. Binary mixing models, with local recharge waters and local seawater as end-member components, point to maximum local seawater contributions of about 1% and 4% for Hotsprings Cove and associated Mate Island thermal waters, respectively. Most chemical and isotopic geothermometer estimates are 90$\sp\circ$C. The Ahouset hotspring, located 12 km south of Hotsprings Cove has low total dissolved solids, a pH of 10.05, and a different geochemistry. Data from the Selkirk Range show a consistent sodium-sulphate geochemistry among the three hotsprings sampled in the Kuskanax Batholith. All waters have low bicarbonate content. $\sp $C values in excess of 100 pmc at the Nakusp hotspring imply incorporation of $\sp $C-active DIC from soil zone organics entrained during recharge, with possible additional $\sp $C contributions occurring due to sulphate reduction and incorporation of soil zone organics during mixing with non-thermal groundwaters near discharge. $\sp $C-derived mean residence times for the sulphide-rich waters of Halcyon hotspring are also short; possibly ${\sim}$1000 years. Geothermometer estimates for all three springs are consistent and fall into two groups, one group near ${\sim}$90$\sp\circ$C and the other between 115$\sp\circ$C and 155$\sp\circ$C. (Abstract shortened by UMI.)
u-topics : Das Wissensmagazin der Universität Ulm, Nr. 356 (51. Jg.), Wintersemester 2021/2022
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Luft- und Raumfahrtforschung
subject: Wildbienen
subject: Energieforschung
subject: Campus
subject: DDC 050 / General serial publications
subject: Universities; Germany; Ulm
subject: Universities and colleges; Germany
subject: Universität Ulm

description: u-topics : Das Wissensmagazin der Universität Ulm
title: Alteraciones en la sustancia blanca cerebral (RM-Difusion tensorial) en pacientes con dolor agudo y crónico.
Creators: name: Granell, Esther
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neuroradiology brain
subject: MR
subject: Outcomes analysis
subject: Biological effects

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
-Estudiar las posibles alteraciones en la sustancia blanca cerebral de pacientes con dolor por Herpes Zoster. -Analizarlas posibles diferencias entre las alteraciones y sus patrones de afectación en pacientes con dolorcrónico por neuralgia...
title: Biogaserzeugung aus Bioabfällen
title: Biogaserzeugung aus Bioabfällen
titleType: AlternativeTitle
Creators: name: Scholwin, Frank
name: Grope, Johan
name: Clinkscales, Angela
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Biogas
subject: Gülle
subject: Bioabfall
subject: Biogasanlage
subject: Biogasgewinnung
subject: EEG
subject: Klima | Energie

description: Gülle und Bioabfälle verursachen nach wie vor durch die notwendige Lagerung, Behandlung und Verwertung relevante Treibhausgasemissionen. Sie werden heute teilweise bereits in Biogasanlagen zur Bereitstellung von erneuerbarer Energie eingesetzt. Es bestehen für diesen Nutzungsweg jedoch noch Ausbaupotenziale.Sie finden die Handlungsempfehlungen für den Einsatz von Bioabfällen in Vergärungsanlagen in diesem Flyer übersichtlich zusammengefasst.
Finding phrases : The interplay of word frequency, phrasal prosody and co-verbal visual information in chunking speech by monolingual and bilingual adults
Creators: name: De La Cruz Pavía, Irene
name: Werker, Janet Feldman, 1951-
name: Vatikiotis-Bateson, Eric
name: Gervain, Judit
Publisher: name: SAGE Publications
Year: 2020

description: The input contains perceptually available cues, which might allow young infants to discover abstract properties of the target language. Thus, word frequency and prosodic prominence correlate systematically with basic word order in natural languages. Prelexical infants are sensitive to these frequency-based and prosodic cues, and use them to parse new input into phrases that follow the order characteristic of their native languages. Importantly, young infants readily integrate auditory and visual facial information while processing language. Here, we ask whether co-verbal visual information provided by talking faces also helps prelexical infants learn the word order of their native language in addition to word frequency and prosodic prominence. We created two structurally ambiguous artificial languages containing head nods produced by an animated avatar, aligned or misaligned with the frequency-based and prosodic information. During 4 minutes, two groups of 4- and 8-month-old infants were familiarized with the artificial language containing aligned auditory and visual cues, while two further groups were exposed to the misaligned language. Using a modified Headturn Preference Procedure, we tested infants’ preference for test items exhibiting the word order of the native language, French, vs. the opposite word order. At 4 months, infants had no preference, suggesting that 4-month-olds were not able to integrate the three available cues, or had not yet built a representation of word order. By contrast, 8-month-olds showed no preference when auditory and visual cues were aligned and a preference for the native word order 44 when visual cues were misaligned. These results imply that infants at this age start to integrate the co-verbal visual and auditory cues.
title: Stellate blockade combined to iloprost as supportive treatment option improves pain and ischaemic symptoms in patients with systemic sclerosis
Creators: name: Höcketstaller, Franziska
name: Henkemeier, Ulf
name: Zimmermann, Michael
name: Burkhardt, Harald
name: Behrens, Frank
name: Drott, Ulrich
name: Köhm, Michaela
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Peripheral ischaemia is a common symptom in systemic sclerosis (SSc) patients with risk of development of ischaemic digital ulcers (DU) and limb loss. Since accompanying pain symptoms might worsen the ischaemic symptoms, a combination of intravenous Iloprost with anaesthetic procedures[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Personality associations with smartphone and internet use disorder: a comparison study including links to impulsivity and social anxiety
Creators: name: Peterka-Bonetta, Jessica
name: Sindermann, Cornelia
name: Elhai, Jon D.
name: Montag, Christian
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Internet use disorder
subject: Smartphone use disorder
subject: Smartphone addiction
subject: Big five model of personality
subject: Problematic internet use
subject: Problematic smartphone use
subject: DDC 150 / Psychology
subject: Internet addiction
subject: Cell phones; Psychological aspects
subject: Screen time
subject: Behavior, Addictive
subject: Personality
subject: Online-Sucht
subject: Smartphone
subject: Fünffaktorenmodell der Persönlichkeit

description: The present work aims to replicate findings linking specific personality traits with Internet and Smartphone Use Disorder (IUD/SUD). Specifically, earlier research demonstrated that tendencies toward IUD and SUD are associated with high Neuroticism and both low Conscientiousness and low Agreeableness, while IUD (but not SUD) tendencies are negatively related to Extraversion and SUD (but not IUD) tendencies are negatively associated with Openness (1). In the aftermath of the replication crisis in psychology and related disciplines, it has become increasingly important to replicate findings in psychological research. Therefore, we revisited this earlier study by investigating (i) a sample from different countries and (ii) using different questionnaires to assess IUD, SUD and the Five Factor Model of Personality than the earlier work by Lachmann et al. (1). By applying such a design, we believe that replicating results from this earlier study hints toward generalizable associations being (largely) independent from that sample’s specific cultural background and instrumentation. Importantly (iii) we used a larger sample consisting of N = 773 in the present study to have higher statistical power to observe the initially reported associations. Additionally, we investigated the role of impulsivity and social anxiety on IUD/SUD, further illuminating the nature of these potential new disorders. Indeed, we were able to reaffirm the aforementioned correlation patterns between personality and IUD/SUD in the present work to a large extent, with low Conscientiousness and high Neuroticism being most robustly associated with higher IUD/SUD. Furthermore, social anxiety and impulsivity showed positive correlations with IUD and SUD, as expected.
Functional analysis of two novel zebrafish genes involved in the formation of actinotrichia during fin development and regeneration
Creators: name: Wagh, Purva
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Molecular.

description: In a screen for genes differentially expressed during fin regeneration in adult zebrafish, two novel genes, 2-H06 and 2-F11, belonging to the same family coding for secreted proteins with unknown function, were identified. Besides their expression during fin regeneration, they are specifically expressed in the embryonic fins of zebrafish. During development, their expression is restricted to the developing fin folds of both paired and unpaired fins. Searches of the current genomic databases did not reveal any orthologs of 2-H06 or 2-F11 genes in tetrapods, plants and invertebrates species. However, orthologs of the genes are found in other teleost fish like the puffer fish Takifugu rubripes (fugu), Tetraodon nigroviridis and the Medaka fish (Oryzias latipes), and in the cartilaginous fish, elephant shark (Callorhinchus milii). In zebrafish embryos, around hatching time, the first component of the fin exoskeleton is seen. It is made of two layers of collagenous fibrils called actinotrichia. These fibrils are only present in fish fins and their appearance correlates with the onset of the developmental divergence between fish paired fin buds and higher vertebrate limb buds. Functional analysis was performed using the gene "knock-down" approach by injection of morpholino oligonucleotides in 1-cell-stage zebrafish embryos. It revealed no significant defects when the morpholino of each gene was injected individually but co-injection of both of the morpholinos induced a complete absence of the actinotrichia, which led to the fin fold losing its structural integrity. Moreover, rescue analysis performed by co-injecting single stranded mRNA (2-H06 or 2-F11) with the two morpholinos in embryos confirmed that the absence of actinotrichia was a defect specific to the knockdown of the 2-H06 and 2-F11 genes. The results of this study suggest that these two genes encode structural proteins of the actinotrichia and loss of this gene family in species other than fish may be one of the causes or consequences of the evolutionary transition from fins to limbs.
Occurrence and potential environmental risk of surfactants and their transformation products discharged by wastewater treatment plants
Creators: name: Freeling, Finnian
name: Alygizakis, Nikiforos A.
name: Von Der Ohe, Peter C.
Publisher: name: My University
Year: 2019
Subjects: Risikoanalyse

description: Seven-day composite effluent samples from a German monitoring campaign including 33 conventional wastewater treatment plants (WWTP) were analyzed for linear alkylbenzene sulfonates (LAS) and alkyl ethoxysulfates (AES) and were screened by wide-scope suspect screening for 1564 surfactants and their transformation products (TPs) by UHPLC-ESI-QTOF-MS. Corresponding seven-day composite influent samples of selected WWTPs showed high influent concentrations as well as very high removal rates for LAS and AES. However, average total LAS and AES effluent concentrations were still 14.4 ng/L and 0.57 ng/L, respectively. The LAS-byproducts di-alkyl tetralin sulfonates (DATSs), the TPs sulfophenyl alkyl carboxylic acids (SPACs) and sulfo-tetralin alkyl carboxylic acids (STACs) reached maximum effluent concentrations of 19 ng/L, 17 ng/L and 5.3 ng/L, respectively. In many cases the sum of the concentration of all LAS-related byproducts and TPs surpassed the concentration of the precursors. High concentrations of up to 7.4 ng/L were found for 41 polyethylenoglycol homologs. Quantified surfactants and their TPs and by-products together accounted for concentrations up to 82 ng/L in WWTP effluents. To determine the risk of individual surfactants and their mixtures, single homologs were grouped by a "weighted carbon number approach" to derive normalized Predicted No-Effect Concentrations (PNEC), based on experimental ecotoxicity data from existing risk assessments, complemented by suitable Quantitative Structure-Activity Relationships (QSAR) predictions. Predicted Environmental Concentrations (PEC) were derived by dividing effluent concentrations of surfactants by local dilution factors. Risks for all analyzed surfactants were below the commonly accepted PEC/PNEC ratio of 1 for single compounds, while contributions to mixture toxicity effects from background levels of LAS and DATS cannot be excluded. Maximum LAS concentrations exceeded half of its PNEC, which may trigger country-wide screening to investigate potential environmental risks. © 2019 Elsevier B.V. All rights reserved.
Tiny golden angle ultrashort echo‐time lung imaging in mice
Creators: name: Balasch, Anke
name: Metze, Patrick
name: Li, Hao
name: Rottbauer, Wolfgang
name: Abaei, Alireza
name: Rasche, Volker
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: 2D UTE
subject: Fractional ventilation
subject: Lung density
subject: MRI
subject: Self‐gating
subject: T2*
subject: Tiny golden angle
subject: DDC 610 / Medicine & health
subject: Lung
subject: Magnetic resonance imaging
subject: Perfusion
subject: Lunge
subject: Kernspintomografie

description: The feasibility of 2D tyGA UTE for the assessment of lung (proton) density, fractional ventilation, quantitative perfusion and qualitative contrast‐enhanced perfusion at 11.7 T was successfully investigated in mice. Lung parenchyma T2* was quantified for correct signal decay compensation during density calculation. Inter‐ and intra‐reader and interstudy reproducibility were assessed, showing the accuracy of the investigated approach. Imaging the lung parenchyma with MRI is particularly difficult in small animals due to the high respiratory and heart rates, and ultrashort T2* at high magnetic field strength caused by the high susceptibilities induced by the air–tissue interfaces. In this study, a 2D ultrashort echo‐time (UTE) technique was combined with tiny golden angle (tyGA) ordering. Data were acquired continuously at 11.7 T and retrospective center‐of‐k‐space gating was applied to reconstruct respiratory multistage images. Lung (proton) density (fP), T2*, signal‐to‐noise ratio (SNR), fractional ventilation (FV) and perfusion (f) were quantified, and the application to dynamic contrast agent (CA)‐enhanced (DCE) qualitative perfusion assessment tested. The interobserver and intraobserver and interstudy reproducibility of the quantitative parameters were investigated. High‐quality images of the lung parenchyma could be acquired in all animals. Over all lung regions a mean T2* of 0.20 ± 0.05 ms was observed. FV resulted as 0.31 ± 0.13, and a trend towards lower SNR values during inspiration (EX: SNR = 12.48 ± 6.68, IN: SNR = 11.79 ± 5.86) and a significant (P < 0.001) decrease in lung density (EX: fP = 0.69 ± 0.13, IN: fP = 0.62 ± 0.13) were observed. Quantitative perfusion results as 34.63 ± 9.05 mL/cm3/min (systole) and 32.77 ± 8.55 mL/cm3/min (diastole) on average. The CA dynamics could be assessed and, because of the continuous nature of the data acquisition, reconstructed at different temporal resolutions. Where a good to excellent interobserver reproducibility and an excellent intraobserver reproducibility resulted, the interstudy reproducibility was only fair to good. In conclusion, the combination of tiny golden angles with UTE (2D tyGA UTE) resulted in a reliable imaging technique for lung morphology and function in mice, providing uniform k‐space coverage and thus low‐artefact images of the lung parenchyma after gating.
Nature and origin of massive ground ice bodies, Yukon Territory and Alaska
Creators: name: St-Jean, Melanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Geography.

description: Gas bubbles in ice hold relevant information on the origin and process of formation, distinguishing between an atmospheric and dissolved origin. Using ice crystallography, stable O-H isotopes and gas composition, this thesis provides new clues to the understanding of ice wedge formation and filling process in the Yukon Territory and Alaska. An improved extraction line and mass spectrometry technique were used 10 analyze the gas composition of ice bubbles (O2, N2 and Ar). Conclusions from this study infer that climatic conditions may influence the source of infilling during ice wedge growth. Wet and dry environments have result in two different signatures in ice wedges. The Vault Creek tunnel ice wedges in Alaska, dated to the late Pleistocene, a cold and dry period, preserve stable O-H isotope and gas compositions similar to those expected for ice formed by snow densification. On the other hand, ice wedges from the Old Crow region, dated to the late Holocene, preserved isotopic and gas compositions more similar to those expected for ice formed by the freezing of liquid water. In some cases, the results from the occluded gases (O2, N2 and Ar) showed low oxygen concentration and high delta18O values, indicating respiration prior to formation. These results are significant to palaeoclimatic interpretation of ice wedges in permafrost areas.
title: Rheuma-VOR: Nutzung und Validierung des PEST- und EARP-Fragebogen in der Frühdiagnostik der Psoriasis Arthritis
Creators: name: Neumaier, Maria
name: Dreher, Matthias
name: Wegner, Johanna
name: Staubach-Renz, Petra
name: Schwarting, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Psoriasis Arthritis (PsA) ist eine autoimmun-inflammatorische Erkrankung mit chronischem, schubweise auftretendem und gelenkdestruierendem Verlauf. Dementsprechend sind eine frühzeitige Diagnose und eine zügige Therapieeinleitung relevant [ref:1]. Obwohl in Deutschland[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Supplementary document for Direct Comparison with Terahertz Metamaterials and Surface-Enhanced Raman Scattering in Molecular-Specific Sensing Performance - 4986703.pdf
Creators: name: Lee, Soohyun
name: Roh, Yeeun
name: Lee, Sang-Hun
name: Ryu, Yong-Sang
name: Ju, Byeong-Kwon
name: Seo, Minah
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental Document
A qualitative assessment of communicating spatial concepts in virtual and physical environments via a text-based medium
Creators: name: Puade, Onn Azraai
name: Wyeld, Theodor G.
Publisher: name: Swinburne
Year: 2024

description: The pedagogical exercise described here was used to investigate how spatial communication about the manipulation of objects in a virtual and physical space is communicated between remote partners. It continues work done by others. Where it differs from previous research in this area is in its use of a qualitative methodology to study how these types of interactions are structured, communicated and interpreted via text-based media. What emerged from the qualitative analysis are new insights over the previous quantitative investigations. This paper reports on completed research.
A Small RNA Is Linking CRISPR–Cas and Zinc Transport
Creators: name: Märkle, Pascal
name: Maier, Lisa-Katharina
name: Maaß, Sandra
name: Hirschfeld, Claudia
name: Bartel, Jürgen
name: Becher, Dörte
name: Voß, Björn
name: Marchfelder, Anita
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: CRISPR-Cas
subject: zinc transport
subject: haloarchaea
subject: DDC 570 / Life sciences
subject: Non-coding RNA
subject: Archaebacteria
subject: RNA, Small Untranslated
subject: Archaea
subject: CRISPR-Cas Systems
subject: Small RNA
subject: Archaebakterien

description: The function and mode of action of small regulatory RNAs is currently still understudied in archaea. In the halophilic archaeon Haloferax volcanii, a plethora of sRNAs have been identified; however, in-depth functional analysis is missing for most of them. We selected a small RNA (s479) from Haloferax volcanii for detailed characterization. The sRNA gene is encoded between a CRISPR RNA locus and the Cas protein gene cluster, and the s479 deletion strain is viable and was characterized in detail. Transcriptome studies of wild-type Haloferax cells and the deletion mutant revealed upregulation of six genes in the deletion strain, showing that this sRNA has a clearly defined function. Three of the six upregulated genes encode potential zinc transporter proteins (ZnuA1, ZnuB1, and ZnuC1) suggesting the involvement of s479 in the regulation of zinc transport. Upregulation of these genes in the deletion strain was confirmed by northern blot and proteome analyses. Furthermore, electrophoretic mobility shift assays demonstrate a direct interaction of s479 with the target znuC1 mRNA. Proteome comparison of wild-type and deletion strains further expanded the regulon of s479 deeply rooting this sRNA within the metabolism of H. volcanii especially the regulation of transporter abundance. Interestingly, s479 is not only encoded next to CRISPR–cas genes, but the mature s479 contains a crRNA-like 5′ handle, and experiments with Cas protein deletion strains indicate maturation by Cas6 and interaction with Cas proteins. Together, this might suggest that the CRISPR–Cas system is involved in s479 function.
title: Kompressionssonographie der Temporalarterien in der Diagnostik der Riesenzellarteriitis bei Patienten mit okulären Durchblutungsstörungen
Creators: name: Czihal, Michael
name: Dechant, Claudia
name: Lottspeich, Christian
name: Köhler, Anton
name: Prearo, Ilarea
name: Hoffmann, Ulrich
name: Schulze-Koops, Hendrik
name: Priglinger, Siegfried
name: Mackert, Marc
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Kompressionssonographie der Temporalarterien (KST) ist eine einfache, reproduzierbare sonographische Methode zur Diagnostik der kranialen Riesenzellarteriitis (RZA). Ziel der vorliegenden Untersuchung war die Validierung der etablierten Cut-Off-Werte für die Wanddicke der Temporalarterien[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ
Creators: name: Wang, Bing
name: Said, Nelly
name: Hilal, Tarek
name: Finazzo, Mark
name: Wahl, Markus C.
name: Artsimovitch, Irina
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Cryoelectron microscopy
subject: Microbiology
subject: FOS: Biological sciences
subject: Transcriptional regulatory elements
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Bacterial RNA helicase ρ is a genome sentinel that terminates the synthesis of damaged and junk RNAs that are not translated by the ribosome. It is unclear how ρ is regulated during dormancy or stress, when translation is inefficient and RNAs are vulnerable to ρ-mediated release. We use cryogenic electron microscopy, biochemical, and genetic approaches to show that substitutions of residues in the connector between two ρ domains or ADP promote the formation of extended Escherichia coli ρ filaments. By contrast, (p)ppGpp induces the formation of transient ρ dodecamers. Our results demonstrate that ADP and (p)ppGpp nucleotides bound at subunit interfaces inhibit ρ ring closure that underpins the hexamer activation, thus favoring the assembly of inactive higher-order oligomers. Connector substitutions and antibiotics that inhibit RNA and protein syntheses trigger ρ aggregation in the cell. These and other recent data implicate aggregation as a widespread strategy to tune ρ activity.
title: Feinstaubbelastung Neujahr 2020 und 2021: Vergleich der Auswertungen zweier Pollenfallen in Berlin
title: Particulate matter Pollution at New Year 2020 and 2021: Comparing two pollen traps in Berlin
titleType: AlternativeTitle
Creators: name: Emanuel, Carola
name: Straff, Wolfgang
name: Süring, Katrin
Publisher: name: My University
Year: 2021

description: Silvesterfeuerwerk führt oft zu einer vorübergehend messbaren Luftbelastung insbesondere mit Feinstaub: Partikel kleiner 10 (micro)m (PM10) und kleiner 2,5 (micro)m (PM2.5). Aufgrund der strengen Einschränkungen des öffentlichen Lebens und des weitgehenden Ausfalls des Feuerwerks war dies zum Jahreswechsel 2020/21 wesentlich weniger ausgeprägt. Wir stellen hier die Auswertungen zweier konventioneller Pollenfallen (Burkhard-Fallen) im zeitlichen Verlauf des Jahreswechsels 2019/20 und 2020/21 vor. Diese optische Partikelanalysemethode ist zwar nicht für Feinstaubmessungen validiert, kann diese aber dennoch anschaulich und zeitbezogen illustrieren. Die Ergebnisse werden den offiziell berichteten PM10-Messwerten von Berliner Luftgütemessstationen an den betreffenden Neujahrstagen gegenübergestellt. Die Visualisierung von Fein- und Grobstaubbelastungen (bis 80ÎÌm Durchmesser) kann die Kommunikation über gesundheitlich relevante Expositionen durch Luftverunreinigungen unterstützen. Quelle: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz / Boden- und Lufthygiene (Berlin) Institut für Wasser-. - (2021), Heft 2, Seite 39
description: New Year's Eve fireworks usually lead to significant air pollution with particulate matter. Compared to the previous year, the turn of the year 2020/21 led to considerably lower air pollution with fine dust due to the strict restrictions on public life and the extensive limitations of the fireworks. We present the temporal progressions of two devices intended and used for the collection of pollen. The optical particle analysis is typically not validated for particle measurements, nevertheless fine and coarse dust (up to 80 (micro)m diameter) particles can be illustrated with reference to the time of exposure. These results are compared with the officially reported results for particulate matter (PM10) of Berlin air quality stations on the relevant New Year's Days. The visual documentation of fine and coarse dust pollution can support communication about health-relevant exposures to air pollution. Quelle: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz / Boden- und Lufthygiene (Berlin) Institut für Wasser-. - (2021), Heft 2, Seite 39
title: Detektion von subklinischer Hautmanifestation bei Patienten mit Psoriasis und Psoriasis-Arthritis mittels fluoreszenzoptischer Bildgebung
Creators: name: Ohrndorf, Sarah
name: Schmidt, Angelique
name: Glimm, Anne-Marie
name: Hoff, Paula
name: Schmittat, Gabriela
name: Burmester, Gerd-Rüdiger
name: Klotsche, Jens
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Fluoreszenzoptische Bildgebung (FOI) als neue Bildgebungstechnik ermöglicht die Visualisierung einer gestörten Mikrozirkulation in beiden Händen, welche zum Beispiel durch eine Gelenkentzündung bedingt wird. Der Nachweis einer Hautbeteiligung bei Psoriasis, bei der auch[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Comparing Sentinel-2 MSI and Landsat 8 OLI Imagery for Monitoring Selective Logging in the Brazilian Amazon
Creators: name: Lima, Thaís Almeida
name: Beuchle, René
name: Langner, Andreas
name: Grecchi, Rosana Cristina
name: Griess, Verena C.
name: Achard, Frédéric
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Imagery from medium resolution satellites, such as Landsat, have long been used to map forest disturbances in the tropics. However, the Landsat spatial resolution (30 m) has often been considered too coarse for reliably mapping small-scale selective logging. Imagery from the recently launched Sentinel-2 sensor, with a resampled 10 m spatial resolution, may improve the detection of forest disturbances. This study compared the performance of Landsat 8 and Sentinel-2 data for the detection of selective logging in an area located in the Brazilian Amazon. Logging impacts in seven areas, which had governmental authorization for harvesting timber, were mapped by calculating the difference of a self-referenced normalized burn ratio (ΔrNBR) index over corresponding time periods (2016–2017) for imagery of both satellite sensors. A robust reference dataset was built using both high- and very-high-resolution imagery. It was used to define optimum ΔrNBR thresholds for forest disturbance maps, via a bootstrapping procedure, and for estimating accuracies and areas. A further assessment of our approach was also performed in three unlogged areas. Additionally, field data regarding logging infrastructure were collected in the seven study sites where logging occurred. Both satellites showed the same performance in terms of accuracy, with area-adjusted overall accuracies of 96.7% and 95.7% for Sentinel-2 and Landsat 8, respectively. However, Landsat 8 mapped 36.9% more area of selective logging compared to Sentinel-2 data. Logging infrastructure was better detected from Sentinel-2 (43.2%) than Landsat 8 (35.5%) data, confirming its potential for mapping small-scale logging. We assessed the impacted area by selective logging with a regular 300 m × 300 m grid over the pixel-based results, leading to 1143 ha and 1197 ha of disturbed forest on Sentinel-2 and Landsat 8 data, respectively. No substantial differences in terms of accuracy were found by adding three unlogged areas to the original seven study sites.
title: Wie hoch ist die Strahlenexposition bei rheumatologischer Diagnostik?
Creators: name: Kayser, Marten
name: Unger, Leonore
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Mit unserem Poster wollen wir untersuchen, welches Strahlenrisiko durch die übliche internistisch-rheumatologische Diagnostik für unsere Patienten entsteht. Ziel soll es sein, das Bewusstsein für die ausgelöste Exposition zu schärfen und Unsicherheiten über [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
La complexité communicationnelle de l'action collective, pour se réinventer
Creators: name: Forest, Marieve
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Sociology, General.

description: Par ce document écrit, accompagné d'un document audiovisuel, nous avons voulu jeter un regard différent sur l'action collective. Afin de mettre en valeur le caractère construit de l'action collective, nous nous sommes attardé aux processus communicationnels et aux langages créés ou échangés. Ainsi, nous avons pu établir des liens entre les formes que prend la communication sociale aujourd'hui et les formes épousées par l'action collective. Ces considérations assez générales donnent sens à l'action collective et éclairent les pratiques quotidiennes des acteurs. Ensuite, c'est par les catégories de la pratique, comme le corps, l'espace, le temps, les images créées et les paroles échangées, que l'originalité et la complexité communicationnelle de l'action collective sont mises à jour. C'est alors qu'une compréhension plus prononcée des significations données par l'acteur, des champs et objectifs de l'action, de l'identité découlant du collectif et du conflit poussant à l'action, est possible.
title: Paradigmenwechsel: Personalisierte Diagnostik, genetische/epigenetische Prädispositions-Faktor-, Biomarker-Analyse in den präklinischen, subklinischen, prodromalenund klassifizierbaren Phasen der Spondyloarthritis psoriatica Krankheitsgruppe – eine prospektive, kontrollierte Langzeit-Studie von 7000 Fällen
Creators: name: Muraközy, Henriette
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Paradigmenwechsel: Personalisierte Diagnostik, genetische/epigenetische Prädispositions-Faktor-, Biomarker-Analyse in den präklinischen, subklinischen, prodromalenund klassifizierbaren Phasen der Spondyloarthritis psoriatica Krankheitsgruppe – eine prospektive, kontrollierte Langzeit-Studie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Supplementary document for Uncertainty assessment of unattended above-water radiometric data collection from research vessels with the Dynamic Above-Water Radiance (L) and Irradiance (E) Collector (DALEC) - 4986829.pdf
Creators: name: Antoine, David
name: Slivkoff, Matthew
name: Klonowski, Wojciech
name: Kovach, Charles
name: ondrusek, michael
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Additional figures
Effets de l'intensité de l'exercice sur le comportement alimentaire chez la femme
Creators: name: Pomerleau, Marjorie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Health Sciences, Nutrition.
subject: Health Sciences, Recreation.

description: Il a été démontré que l'intensité de l'exercice influence l'apport énergétique chez les hommes. L'objectif principal de cette étude portrait sur l'investigation des effets de l'intensité de l'exercice sur la prise alimentaire, la préférence macronutritionnelle, l'appétit et le profil hormonal chez des jeunes femmes. Treize jeunes femmes de poids normal et modérément actives ont participé à trois conditions expérimentales: Contrôle (C) sans exercice et deux sessions d'exercice équicaloriques (350 kilocalories), soit à faible (EFI) et haute (EHI) intensité, pratiquées à 40% et 70% de la consommation maximale d'oxygène (VO 2 peak), respectivement. À la suite de chacune de ces sessions, deux buffets (dîner et souper) ainsi que des collations (en après-midi et en soirée) ont été offerts aux participantes, qui pouvaient manger à volonté les aliments qui leurs étaient présentés. (Abstract shortened by UMI.)