cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chiral Gravity Waves and Leptogenesis in Inflationary Models with non-Abelian Gauge Fields
Creators: name: Maleknejad, Azadeh
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a leptogenesis scenario associated with inflationary models involving non-Abelian gauge fields within the standard model of particle physics (SM). We show that this class of inflationary models generates intrinsic birefringent gravitational waves that through the gravitational chiral anomaly in SM, can naturally create a net lepton number density. The CP violating interaction is produced by tensor fluctuations of the gauge field, while the efficiency of this process is determined by the effective background value of the gauge field. We demonstrate that this mechanism can create the observed value of baryon to photon number density in a natural range of parameters of these models.
description: 18 pages, 2 figures, minor comments added, version accepted for publication in PRD
OʻQUVCHILARNING IJTIMOIY YETUKLIGI VA TASHKILOTCHILIK QOBILIYATI
Creators: name: Oʻrmonova, Mubinaxon
name: Bobayeva, Ziyodaxon
Publisher: name: Zenodo
Year: 2025

description: ushbu maqolada kichik maktab yoshidagi o‘quvchi shaxsida tashkilotchilik qobiliyatini rivojlanishida jamoaning tutgan o‘rni haqida masalar yoritib o’tilgan.
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
Creators: name: Kim, Dae
name: Kim, Kyung-Ok
name: Shin, Mike
name: Ha, Jung
name: Seo, Sung
name: Yang, Jay
name: Lee, Francis Y.
Publisher: name: Columbia University
Year: 2009
Subjects: subject: P-glycoprotein
subject: Small interfering RNA
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular biology

description: Background: High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprotein and antiapoptotic proteins in the chemoresistance to doxorubicin of two Grade II chondrosarcoma cell lines, JJ012 and SW1353. Results: We confirmed that both chondrosarcoma cell types expressed P-glycoprotein and antiapoptotic proteins (Bcl-2, Bcl-xL and XIAP). siRNA knockdown as well as pharmacologic inhibitors of cell survival proteins (Bcl-2, Bcl-xL and XIAP) enhanced apoptosis of chemoresistant chondrosarcoma cells by up to 5.5 fold at 0.1 μmol and 5.5 fold at 1 μmol doxorubicin. These chemosensitizing effects were comparable to those of P-glycoprotein inhibition by siRNA or pharmacologic inhibitor. Conclusion: These findings suggest that antiapoptotic proteins play a significant role in the chemoresistance of chondrosarcoma cells independent of P-glycoprotein. Based on the results, a new siRNA-based therapeutic strategy targeting antiapoptotic genes can be designed to overcome the chemoresistance of chondrosarcomas which is often conferred by P-glycoprotein.
Petromus typicus A. Smith 1831
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Petromyidae
Petromus
Petromus typicus

description: Petromus typicus A. Smith, 1831. S. Afr. Quart. J., 1 (5): 11. TYPE LOCALITY: South Africa, mouth of Orange River. DISTRIBUTION: W. South Africa to S.W. Angola. ISIS NUMBER: 5301410031001001001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 592, DOI: 10.5281/zenodo.7353039
Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons
Creators: name: Tong, Chi-Kun
name: Kaftan, Edward
name: MacDermott, Amy B.
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurons
subject: Cell receptors
subject: Genetics
subject: FOS: Biological sciences
subject: Neurosciences
subject: FOS: Clinical medicine

description: NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed of two NR1 and two of four NR2 subunits: NR2A-2D. Mice lacking specific NR2 subunits show deficits in pain transmission yet subunit location in the spinal cord remains unclear. We have combined electrophysiological and pharmacological approaches to investigate the composition of functional NMDA receptors expressed by lamina I, substance P receptor-expressing (NK1R+) neurons, as well as NK1R- neurons. Under low Mg2+ conditions (100 μM), the conductance of NMDA receptors at -90 mV (g(-90 mV)) with NR2A or NR2B subunits (NR2A/B) is low compared to conductance measured at the membrane potential where the inward current is maximal or maximal inward current (MIC) (ratio of ~0.07 calculated from Kuner and Schoepfer, 1996). For NR2C or NR2D subunits (NR2C/D), the ratio is higher (ratio ~0.4). NK1R+ and NK1R- neurons express NMDA receptors that give ratios ~0.28 and 0.16, respectively, suggesting both types of subunits are present in both populations of neurons, with NK1R+ neurons expressing a higher percentage of NR2C/D type NMDA receptors. This was confirmed using EAB318, an NR2A/B preferring antagonist, and UBP141, a mildly selective NR2C/D antagonist to increase and decrease the g(-90 mV)/g(MIC) ratios in both subpopulations of neurons.
Improving the cost-effectiveness of IRS with climate informed health surveillance systems
Creators: name: Worrall, Eve
name: Connor, Stephen J.
name: Thomson, Madeleine C.
Publisher: name: Columbia University
Year: 2008
Subjects: Malaria
Climatology
Epidemiology

description: Background: This paper examines how the cost-effectiveness of IRS varies depending on the severity of transmission and level of programme coverage and how efficiency could be improved by incorporating climate information into decision making for malaria control programmes as part of an integrated Malaria Early Warning and Response System (MEWS). Methods: A climate driven model of malaria transmission was used to simulate cost-effectiveness of alternative IRS coverage levels over six epidemic and non-epidemic years. Decision rules for a potential MEWS system that triggers different IRS coverage are described. The average and marginal cost per case averted with baseline IRS coverage (24%) and under varying IRS coverage levels (50%, 75% and 100%) were calculated. Results: Average cost-effectiveness of 24% coverage varies dramatically between years, from US$108 per case prevented in low transmission to US$0.42 in epidemic years. Similarly for higher coverage (24–100%) cost per case prevented is far higher in low than high transmission years ($108–$267 to $0.88–$2.26). Discussion: Efficiency and health benefit gains could be achieved by implementing MEWS that provides timely, accurate information. Evidence from southern Africa, (especially Botswana) supports this. Conclusion: Advance knowledge of transmission severity can help managers make coverage decisions which optimise resource use and exploit efficiency gains if a fully integrated MEWS is in place alongside a health system with sufficient flexibility to modify control plans in response to information. More countries and programmes should be supported to use the best available evidence and science to integrate climate informed MEWS into decision making within malaria control programmes.
British Columbia Legislative Assembly sessional clipping book (1945-03)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
The future impact of population growth and aging on coronary heart disease in China: projections from the Coronary Heart Disease Policy Model-China
Creators: name: Moran, Andrew
name: Zhao, Dong
name: Gu, Dongfeng
name: Coxson, Pamela
name: Chen, Chung-Shiuan
name: Cheng, Jun
name: Liu, Jing
name: He, Jiang
name: Goldman, Lee
Publisher: name: Columbia University
Year: 2008
Subjects: Coronary heart disease
Medicine
Medical sciences

description: Background: China will experience an overall growth and aging of its adult population in coming decades. We used a computer model to forecast the future impact of these demographic changes on coronary heart disease (CHD) in China. Methods: The CHD Policy Model is a validated state-transition, computer simulation of CHD on a national scale. China-specific CHD risk factor, incidence, case-fatality, and prevalence data were incorporated, and a CHD prediction model was generated from a Chinese cohort study and calibrated to age-specific Chinese mortality rates. Disability-adjusted life years (DALYs) due to CHD were calculated using standard methods. The projected population of China aged 35–84 years was entered, and CHD events, deaths, and DALYs were simulated over 2000–2029. CHD risk factors other than age and case-fatality were held at year 2000 levels. Sensitivity analyses tested uncertainty regarding CHD mortality coding, the proportion of total deaths attributable to CHD, and case-fatality. Results: We predicted 7.8 million excess CHD events (a 69% increase) and 3.4 million excess CHD deaths (a 64% increase) in the decade 2020–2029 compared with 2000–2009. For 2030, we predicted 71% of almost one million annual CHD deaths will occur in persons ≥ 65 years old, while 67% of the growing annual burden of CHD death and disability will weigh on adults < 65 years old. Substituting alternate CHD mortality assumptions led to 17–20% more predicted CHD deaths over 2000–2029, though the pattern of increases in CHD events and deaths over time remained. Conclusion: We forecast that absolute numbers of CHD events and deaths will increase dramatically in China over 2010–2029, due to a growing and aging population alone. Recent data suggest CHD risk factor levels are increasing, so our projections may underestimate the extent of the potential CHD epidemic in China.
CULTURAL POLICIES AND THE SHAPING OF THE CONTEMPORARY PERFORMING ARTS LANDSCAPE: A GLOBAL PERSPECTIVE
Creators: name: Dr. M. SUBBIAH*
Publisher: name: Zenodo
Year: 2025
Subjects: Cultural policies, Performing arts, Dram and Theatre Arts, Contemporary arts landscape, Global perspective, Cultural governance, Arts sustainability, Diversity in the arts, International collaborations, Cultural diplomacy, Artistic expression, Government support for the arts, Creative industries, Arts funding models, Cultural institutions, Policy impact on the arts.

description: Abstract: This abstract provides a detailed overview of a research article that systematically examines the complex interconnection between cultural policies and the transformation of the global contemporary performing arts landscape. The study employs a rigorous and expansive methodology to scrutinize the influence of diverse cultural policies implemented by governments and cultural institutions. The research specifically focuses on elucidating the impact of these policies on fostering key elements within the performing arts sector, including creativity, diversity, and sustainability.

To substantiate the findings, the study draws upon a diverse array of evidentiary sources, encompassing international case studies, policy documents, and scholarly works. This extensive evidentiary support serves as the foundation for constructing a nuanced understanding of the dynamic interplay between cultural governance and the performing arts. By weaving together insights from various regions and contexts, the research aims to offer a comprehensive and globally relevant exploration of the intricate relationship between cultural policies and the evolving nature of the contemporary performing arts landscape.
Discussions about preventive services: a qualitative study
Creators: name: Lasser, Karen
name: Kelly, Bridget
name: Maier, Jan
name: Murillo, Jennifer
name: Hoover, Sonia
name: Isenberg, Karen
name: Osber, Deborah
name: Pilkauskas, Natasha
name: Willis, Bayo
name: Hersey, James
Publisher: name: Columbia University
Year: 2008
Subjects: Primary care (Medicine)
Older people
Medical sciences
Social sciences--Research

description: Background: Elderly minority patients are less likely to receive influenza vaccination and colorectal cancer screening than are other patients. Communication between primary care providers (PCPs) and patients may affect service receipt. Methods: Encounters between 7 PCPs and 18 elderly patients were observed and audiotaped at 2 community health centers. Three investigators coded transcribed audiotapes and field notes. We used qualitative analysis to identify specific potential barriers to completion of preventive services and to highlight examples of how physicians used patient-centered communication and other facilitation strategies to overcome those barriers. Results: Sharing of power and responsibility, the use of empathy, and treating the patient like a person were all important communication strategies which seemed to help address barriers to vaccination and colonoscopy. Other potential facilitators of receipt of influenza vaccine included (1) cultural competence, (2) PCP introduction of the discussion, (3) persistence of the PCP (revisiting the topic throughout the visit), (4) rapport and trust between the patient and PCP, and (5) PCP vaccination of the patient. PCP persistence as well as rapport and trust also appeared to facilitate receipt of colorectal cancer screening. Conclusion: Several communications strategies appeared to facilitate PCP communications with older patients to promote acceptance of flu vaccination and colorectal cancer screening. These strategies should be studied with larger samples to determine which are most predictive of compliance with prevention recommendations.
A staged strategy for pathogen surveillance and discovery
Creators: name: Lipkin, W. Ian
name: Briese, Thomas
name: Palacios, Gustavo
name: Quan, Phuong-Lan
name: Honkavuori, Kirsi
name: Hornig, Mady
name: Street, Craig
name: Jabado, Omar
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Communicable diseases
subject: Pathogenic microorganisms
subject: Epidemiology
subject: Microbiology
subject: FOS: Biological sciences

description: Recent advances in molecular diagnostics have revolutionized microbiology by facilitating rapid, sensitive pathogen surveillance and differential diagnosis of infectious diseases. Implementation of these technologies can enable intervention when the prognosis is optimal for limiting replication, dissemination, transmission, morbidity and mortality. It may also reveal unappreciated links between infection and chronic diseases. Although new pathogens continue to emerge, we have likely collected much of the "low hanging fruit" (microbes readily associated with diseases). An important task now is to understand those disorders that reflect the interaction of microbes with other environmental factors (toxins, other stressors) and susceptibility genes in a developmental context. Here I will review the strengths and limitations of various assay platforms, describe the challenges associated with proving causation, and delineate a staged strategy for pathogen discovery focused in emerging infectious disease "hot spots," "hot hosts," and prospective birth cohorts.
title: Religio Victoriosa; [1729]
title: Das ist: Siegreiche Religion, Welche Trebellivs Ein König der Bulgarer An seinem von dem wahren Glauben abtrinnigen Sohn durch eyferigst vorgenommene Rach bestättiget hat ... Praelato Domino Domino Dominico Imperialis, & Collegii Roggenburgensis Abbati Vigilantissimo Studiorum Evergetae perquàm Gratioso Scenicè producta, et exhibita In Aula Roggenburgensi Per ejusdem devotissimos theatralis Palladis Alumnos Anno post partum Virginis 1729. 5. Septembr.
titleType: Subtitle
Creators: name: Jacob, Caelestinus
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Perioche
The early phase of multiple proto-stellar system emerged from collapse of molecular cloud under various initial thermal states
Creators: name: Riaz, Rafil
name: Farooqui, Suhail Zaki
name: Vanaverbeke, Siegfried
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: An attempt is made here to revisit structure formation in a proto-stellar cloud during the early phase of evolution. Molecular cloud subjected to a set of various initial conditions in terms of initial temperature and amplitude of azimuthal density perturbation is investigated numerically. Special emphasis remained on the analysis of ring and spiral type instabilities that have shown dependence on certain initial conditions chosen for a rotating solar mass cloud of molecular hydrogen. Generally, a star forming hydrogen gas is considered to be initially at 10K. We have found that a possible oscillation around this typical value can affect the fate of a collapsing cloud in terms of its evolving structural properties leading to proto-star formation. We explored the initial temperature range of cloud between 8K to 12K and compared physical properties of each within the first phase of proto-star formation. We suggest that the spiral structures are more likely to form in strongly perturbed molecular cores that initiate their phase of collapse from temperatures below 10K. Whereas, cores with initial temperatures above 10K develop, instead of spiral, a ring type structure which subsequently experiences the fragmentation. A transition from spiral to ring instability can be observed at a typical initial temperature of 10K.
NPHS2 variation in focal and segmental glomerulosclerosis
Creators: name: Tonna, Stephen
name: Needham, Alexander
name: Polu, Krishna
name: Uscinski, Andrea
name: Appel, Gerald B.
name: Falk, Ronald
name: Katz, Avi
name: Al-Waheeb, Salah
name: Kaplan, Bernard
name: Jerums, George
name: Savige, Judy
name: Harmon, Jennifer
name: Zhang, Kang
name: Curhan, Gary
name: Pollak, Martin
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Mutation (Biology)
subject: Proteinuria
subject: Genetics
subject: FOS: Biological sciences
subject: Medical sciences

description: Background: Focal and segmental glomerulosclerosis (FSGS) is the most common histologic pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10–30% of pediatric cases of steroid resistant nephrosis and/or FSGS. Methods: We studied the spectrum of genetic variation in 371 individuals with predominantly late onset FSGS (mean age of onset 25 years) by analysis of DNA samples. Results: We identified 15 non-synonymous alleles that changed the amino acid sequence in 63 of the subjects screened (17%). Eight of these (p.R138Q, p.V180M, p.R229Q, p.E237Q, p.A242V, p.A284V, p.L327F and the frameshift 855–856 delAA) are alleles previously reported to cause FSGS in either the homozygous or compound heterozygous states, while the remaining 7 (p.R10T, p.V127W, p.Q215X, p.T232I, p.L270F, p.L312V and the frameshift 397delA) are novel alleles that have not been demonstrated previously. Twelve individuals of the 371 (3.2%) screened had two likely disease-causing NPHS2 alleles, present in either a homozygous or compound heterozygous state. We genotyped the two most common of the non-synonymous NPHS2 alleles (p.A242V and p.R229Q) identified by resequencing in participants from the Nurses' Health Study and also genotyped p.R229Q in 3 diabetic cohorts. We found that the presence of either of these variants does not significantly alter the risk of albuminuria in the Nurses' Health participants, nor does p.R229Q associate with "diabetic nephropathy". Conclusion: NPHS2 mutations are a rare cause of FSGS in adults. The most common non-synonymous NPHS2 variants, p.R229Q and p.A242V, do not appear to alter the risk of proteinuria in the general population nor does p.R229Q associate with measures of kidney dysfunction in diabetic individuals. Our results help clarify the frequency of FSGS-causing NPHS2 mutations in adults and broaden our understanding of the spectrum of NPHS2 mutations that lead to human disease.
Families of hyperfinite subfactors with the same standard invariant and prescribed fundamental group
Creators: name: Brothier, Arnaud
name: Vaes, Stefaan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: We construct irreducible hyperfinite subfactors of index 6 with a prescribed fundamental group from a large family containing all countable and many uncountable subgroups of R_+. We also prove that there are unclassifiably many irreducible hyperfinite group-type subfactors of index 6 that all have the same standard invariant. More precisely, we associate such a subfactor to every ergodic measure preserving automorphism of the interval [0,1] and prove that the resulting subfactors are isomorphic if and only if the automorphisms are conjugate.
Ultrafast Quenching of the Exchange Interaction in a Mott Insulator
Creators: name: Mentink, J. H.
name: Eckstein, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate how fast and how effective photocarrier excitation can modify the exchange interaction $J_\mathrm{ex}$ in the prototype Mott-Hubbard insulator. We demonstrate an ultrafast quenching of $J_\mathrm{ex}$ both by evaluating exchange integrals from a time-dependent response formalism and by explicitly simulating laser-induced spin precession in an antiferromagnet that is canted by an external magnetic field. In both cases, the electron dynamics is obtained from nonequilibrium dynamical mean-field theory. We find that the modified $J_\mathrm{ex}$ emerges already within a few electron hopping times after the pulse, with a reduction that is comparable to the effect of chemical doping.
description: 8 pages, 4 figures
On drug treatment and social control: Russian narcology's great leap backwards
Creators: name: Elovich, Richard
name: Drucker, Ernest
Publisher: name: Columbia University
Year: 2008
Subjects: Narcotics
HIV infections
Epidemiology
Slavs

description: The medical discipline of narcology in Russia is a subspecialty of psychiatry from the Soviet era and it is given warrant to define the scope of health activities with regard to alcohol and other drug use, drug users, and related problems. Narcological practice is in turn constrained by the State. The emergence of widespread injection opiate use and associated HIV morbidities and mortalities during the first decade following the collapse of the Soviet Union has brought the contradictions in Russian narcological discourse into high relief. Narcology officials in the Russian Federation have consistently opposed substitution treatment for opiate dependence – the replacement of a short-acting illegal substance with a longer acting prescribed drug with similar pharmacological action but lower degree of risk. Thus, despite the addition of methadone and buprenorphine to WHO's list of essential medicines in 2005 and multiple position papers by international experts calling for substitution treatment as a critical element in the response to HIV (IOM, 2006; UNODC, UNAIDS, and WHO, 2005), methadone or buprenorphine remain prohibited by law in Russia. The authors detail Russian opposition to the prescription of methadone and buprenorphine, describing four phenomena: (1) the dominance of law enforcement and drug control policy over public health and medical ethics ; (2) the conflation of Soviet era alcoholism treatment with treatment for opiate dependence; (3) the near universal representation of detoxification from drugs as treatment for dependence; and (4) a framework for judging treatment efficacy that is restricted to "cure" versus "failure to cure," and does not admit its poor outcomes or recognize alternative frameworks for gauging treatment of opiate dependence. In keeping with this position, Russian narcology officials have taken an implacable ideological stance toward illicit drug use, the people who use drugs, and their treatment. By adopting policies and practices totally unsupported by scientific evidence and inquiry, officials in Russia have rendered narcology ( and medical practice) insensitive to the alarming rates and continued spread of HIV, with its dire morbidity and mortality rates in the Russian Federation, turning their backs on all the other health problems posed by opiate use and dependence itself.
Additional file 1 of Urine collection in cervical cancer screening – analytical comparison of two HPV DNA assays
Creators: name: Tranberg, Mette
name: Jensen, Jørgen Skov
name: Bech, Bodil Hammer
name: Andersen, Berit
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Cardiology

description: Additional file 1:. Questionnaire.
A simple spiking retina model for exact video stimulus representation
Creators: name: Lazar, Aurel A.
name: Pnevmatikakis, Eftychios
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Sensory stimulation
subject: Neurons
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Electrical engineering

description: A computational model for the representation of visual stimuli with a population of spiking neurons is presented. We show that under mild conditions it is possible to faithfully represent an analog video stream into a sequence of spike trains and provide an algorithm that recovers the video input by using only the spike times of the population. In our model an analog, bandlimited in time, video stream approaches the dendritic trees of a neural population. At each neuron, the multi-dimensional video input is filtered by the neuron's spatiotemporal receptive field, and the one-dimensional output dendritic current enters the soma of the neuron (see Figure 1). The set of the spatial receptive fields is modeled as a Gabor filterbank. The spike generation mechanism is threshold based: Each time the dendritic current exceeds a threshold a spike is fired and the membrane potential is reset by a negative potential through a negative feedback loop that gets triggered by the spike. This simple spike mechanism has been shown to accurately model the responses of various neurons in the early visual system 1. Figure 1 Encoding and decoding mechanisms for video stimuli: The stimulus is filtered by the receptive fields of the neurons and enters the soma Encoding and decoding mechanisms for video stimuli: The stimulus is filtered by the receptive fields of the neurons and enters the soma. Spike generation is threshold based and a negative feedback mechanism resets the membrane potential after each spike. In the decoding part each spike, represented by a delta pulse, is weighted by an appropriate coefficient and then filtered from the same receptive field for stimulus reconstruction. The total sum is passed from a low pass filter to recover the original input stimulus. We prove and demonstrate that we can recover the whole video stream based only on the knowledge of the spike times, provided that the size of the neural population is sufficiently big. Increasing the number of neurons to achieve better representation is consistent with basic neurobiological thought 2. Although very precise, the responses of visual neurons show some variability between subsequent stimulus repeats, which can be attributed to various noise sources 1. We examine the effect of noise on our algorithm and show that the reconstruction quality gracefully degrades when white noise is present at the input or at the feedback loop.
ALMA Nutator Design and Preliminary Performance
Creators: name: Martin-Cocher, Pierre
name: Ford, John
name: Koch, Patrick M.
name: Ni, Chih-Wen
name: Chen, Wei-Long
name: Chen, Ming-Tang
name: Raffin, Philippe
name: Ong, Chin-Long
name: Ho, Paul T. P.
name: Symmes, Arthur
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We report the past two years of collaboration between the different actors on the ALMA nutator. Building on previous developments, the nutator has seen changes in much of the design. A high-modulus carbon fiber structure has been added on the back of the mirror in order to transfer the voice coils forces with less deformation, thus reducing delay problems due to flexing. The controller is now an off-the-shelf National Instrument NI-cRIO, and the amplifier a class D servo drive from Advanced Motion Controls, with high peak power able to drive the coils at 300 Volts DC. The stow mechanism has been totally redesigned to improve on the repeatability and precision of the stow position, which is also the reference for the 26 bits Heidenhain encoders. This also improves on the accuracy of the stow position with wind loading. Finally, the software, written largely with National Instrument's LabView, has been developed. We will discuss these changes and the preliminary performances achieved to date. Keywords: ALMA, nutator, class D, high-modulus carbon fiber.
description: Published: 23 August 2012; 12 pages
Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha
Creators: name: Scotto, Luigi
name: Narayan, Gopeshwar
name: Nandula, Subhadra
name: Subramaniyam, Shivakumar
name: Kaufmann, Andreas
name: Wright, Jason D.
name: Pothuri, Bhavana
name: Mansukhani, Mahesh M.
name: Schneider, Achim
name: Arias-Pulido, Hugo
name: Murty, Vundavalli V.
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Chromosomes
subject: Cervix uteri--Cancer
subject: Molecular biology
subject: Genetics
subject: FOS: Biological sciences

description: Background: Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating tumor-related genes. Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC. Methods: To examine the role of 5p gain, we performed a combination of single nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression analyses on invasive cancer and in various stages of CC progression. Results: The SNP and FISH analyses revealed copy number increase (CNI) of 5p in 63% of invasive CC, which arises at later stages of precancerous lesions in CC development. We integrated chromosome 5 genomic copy number and gene expression data to identify key target over expressed genes as a consequence of 5p gain. One of the candidates identified was Drosha (RNASEN), a gene that is required in the first step of microRNA (miRNA) processing in the nucleus. Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression. Conclusion: Taken together, we demonstrate the power of integrating genomics data with expression data in deciphering tumor-related targets of CNI. Identification of 5p gene targets in CC denotes an important step towards biomarker development and forms a framework for testing as molecular therapeutic targets.
title: D. Buellius, Ord. S. Benedicti. Der Aller-erste Missionarius In der neuen Welt; [1727]
title: Vorgestellt Von der studierenden Jugend, bey denen PP. Benedictinern zu Meran Den 4. und 5. September, Anno 1727
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Perioche. - Vorlageform des Erscheinungsvermerks: Botzen, gedruckt bey Michael Gaßmayr, Hochfürstl. Triendt: und Stadt-Buchdruckern allda
The role of the $Δ(1232)$-resonance in covariant baryon chiral perturbation theory
Creators: name: Alarcón, J. M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We stress, on theoretical and phenomenological grounds, the importance of the $Δ(1232)$-resonance in a chiral effective field theory approach applied to the study of $πN$ scattering. We show how its inclusion as a dynamical degree of freedom allow us to obtain reliably valuable information from $πN$ scattering data.
description: Contribution to NSTAR 2013, May 27-30, 2013, Peniscola (Spain); 4 pages
British Columbia Legislative Assembly sessional clipping book (1946-02)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Resummation of scalar correlator in higher spin black hole background
Creators: name: Beccaria, Matteo
name: Macorini, Guido
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the proposal that predicts holographic duality between certain 2D minimal models at large central charge and Vasiliev 3D higher spin gravity with a single complex field. We compute the scalar correlator in the background of a higher spin black hole at order $\mathcal O(α^{5})$ in the chemical potential $α$ associated with the spin-3 charge. The calculation is performed at generic values of the symmetry algebra $\mbox{hs}[λ]$ parameter $λ$ and for the scalar in three different representations. We then study the perturbative data in the large $λ$ limit and discover remarkable regularities. This leads to formulate a closed formula for the resummation of the leading and subleading terms that scale like $\mathcal O(α^{n}λ^{2n})$ and $\mathcal O(α^{n}\,λ^{2n-1})$ respectively.
description: 18 pages
Two-photon spin states and entanglement states
Creators: name: Liu, Xiao-Jing
name: Wu, Xiang-Yao
name: Lu, Jing-Bin
name: Zhang, Si-Qi
name: Hong-Li
name: Ma, Ji
name: Yuan, Hong-Chun
name: Li, Heng-Mei
name: Gao, Hai-Xin
name: Li, Jing-Wu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we have given the spin states of two-photon, which are expressed by the quadratic combination of two single photon spin states, they are a kind of quantum expression. Otherwise, we give all entanglement states of two-photon, which are different from the xanzsd classical polarization vector expression of two-photon entanglement state.
description: arXiv admin note: text overlap with arXiv:1303.3406 by other authors
Acute maternal stress in pregnancy and schizophrenia in offspring: A cohort prospective study
Creators: name: Malaspina, Dolores
name: Corcoran, Cheryl M.
name: Kleinhaus, K. R.
name: Perrin, M. C.
name: Fennig, S.
name: Nahon, D.
name: Friedlander, Y.
name: Harlap, S.
Publisher: name: Columbia University
Year: 2008
Subjects: Pregnancy
Schizophrenia
Mental health
Clinical psychology

description: Schizophrenia has been linked with intrauterine exposure to maternal stress due to bereavement, famine and major disasters. Recent evidence suggests that human vulnerability may be greatest in the first trimester of gestation and rodent experiments suggest sex specificity. We aimed to describe the consequence of an acute maternal stress, through a follow-up of offspring whose mothers were pregnant during the Arab-Israeli war of 1967. A priori, we focused on gestational month and offspring's sex. Method: In a pilot study linking birth records to Israel's Psychiatric Registry, we analyzed data from a cohort of 88,829 born in Jerusalem in 1964–76. Proportional hazards models were used to estimate the relative risk (RR) of schizophrenia, according to month of birth, gender and other variables, while controlling for father's age and other potential confounders. Other causes of hospitalized psychiatric morbidity (grouped together) were analyzed for comparison. Results: There was a raised incidence of schizophrenia for those who were in the second month of fetal life in June 1967 (RR = 2.3, 1.1–4.7), seen more in females (4.3, 1.7–10.7) than in males (1.2, 0.4–3.8). Results were not explained by secular or seasonal variations, altered birth weight or gestational age. For other conditions, RRs were increased in offspring who had been in the third month of fetal life in June 1967 (2.5, 1.2–5.2), also seen more in females (3.6, 1.3–9.7) than males (1.8, 0.6–5.2). Conclusion: These findings add to a growing literature, in experimental animals and humans, attributing long term consequences for offspring of maternal gestational stress. They suggest both a sex-specificity and a relatively short gestational time-window for gestational effects on vulnerability to schizophrenia.
title: Implementation of the GNS Science Canterbury Seismic Hazard Model in OpenQuake

Creators: name: van Houtte, Chris
name: Abbott, Elizabeth R.
Publisher: name: GNS Science
Year: 2019

description: The Canterbury Seismic Hazard Model (CSHM) quantifies the expected future ground shaking in the Canterbury region, given the initiation of the Canterbury earthquake sequence in 2010. The model comprises a time-dependent background and fault source model, a source model logic tree and a ground motion characterisation logic tree. These logic trees were derived from expert elicitation workshops. The CSHM has been previously implemented in a GNS Science-developed Fortran code, and with the OpenSHA software. This report describes efforts to implement the CSHM in the open-source OpenQuake software, which is a product from the Global Earthquake Model (GEM). It is not the intention of this implementation to replicate the GNS Science Fortran or OpenSHA implementations. Instead, this OpenQuake implementation differs from previous implementations, particularly where there were practical issues in forward application. Specifically, the logic tree for the ground motion characterisation has been modified to allow outputs to be obtained using standard software. Other modifications have been made where there have been recent advances in ground motion modelling and site characterisation. The input files for this implementation have be provided to GEM, and a variety of users will be able to obtain their desired outputs using OpenQuake versions ≥ 3.4. (auth)
title: A taxonomic revision of the members of the Camponotus lateralis species group (Hymenoptera: Formicidae) from Europe, Asia Minor and Caucasia
Creators: name: Bernhard, Seifert
Publisher: name: SOIL ORGANISMS 91(1)
Year: 2019

description: numeric morphology-based alpha-taxonomy | nest centroid clustering | cryptic species | size dimorphism | color polymorphism
Antihypertensive Medication Classes Used among Medicare Beneficiaries Initiating Treatment in 2007–2010
Creators: name: Kent, Shia T.
name: Shimbo, Daichi
name: Huang, Lei
name: Diaz, Keith
name: Kilgore, Meredith L.
name: Oparil, Suzanne
name: Muntner, Paul
Publisher: name: Columbia University
Year: 2014
Subjects: Hypotensive agents
Hypertension--Treatment
Medicare
Health services administration
Medical care
Medical sciences
Medicine

description: Background
After the 2003 publication of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines, there was a 5–10% increase in patients initiating antihypertensive medication with a thiazide-type diuretic, but most patients still did not initiate treatment with this class. There are few contemporary published data on antihypertensive medication classes filled by patients initiating treatment.

Methods and Findings
We used the 5% random Medicare sample to study the initiation of antihypertensive medication between 2007 and 2010. Initiation was defined by the first antihypertensive medication fill preceded by 365 days with no antihypertensive medication fills. We restricted our analysis to beneficiaries ≥65 years who had two or more outpatient visits with a hypertension diagnosis and full Medicare fee-for-service coverage for the 365 days prior to initiation of antihypertensive medication. Between 2007 and 2010, 32,142 beneficiaries in the 5% Medicare sample initiated antihypertensive medication. Initiation with a thiazide-type diuretic decreased from 19.2% in 2007 to 17.9% in 2010. No other changes in medication classes initiated occurred over this period. Among those initiating antihypertensive medication in 2010, 31.3% filled angiotensin-converting enzyme inhibitors (ACE-Is), 26.9% filled beta blockers, 17.2% filled calcium channel blockers, and 14.4% filled angiotensin receptor blockers (ARBs). Initiation with %#62;1 antihypertensive medication class decreased from 25.6% in 2007 to 24.1% in 2010. Patients initiated >1 antihypertensive medication class most commonly with a thiazide-type diuretic and either an ACE-I or ARB.

Conclusion
These results suggest that JNC 7 had a limited long-term impact on the choice of antihypertensive medication class and provide baseline data prior to the publication of the 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults from the Panel Members Appointed to the Eighth Joint National Committee (JNC 8).
Gene Regulatory Network Reconstruction Using Conditional Mutual Information
Creators: name: Liang, Kuo-Ching
name: Wang, Xiaodong
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Gene expression
subject: Genetic regulation
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology

description: The inference of gene regulatory network from expression data is an important area of research that provides insight to the inner workings of a biological system. The relevance-network-based approaches provide a simple and easily-scalable solution to the understanding of interaction between genes. Up until now, most works based on relevance network focus on the discovery of direct regulation using correlation coefficient or mutual information. However, some of the more complicated interactions such as interactive regulation and coregulation are not easily detected. In this work, we propose a relevance network model for gene regulatory network inference which employs both mutual information and conditional mutual information to determine the interactions between genes. For this purpose, we propose a conditional mutual information estimator based on adaptive partitioning which allows us to condition on both discrete and continuous random variables. We provide experimental results that demonstrate that the proposed regulatory network inference algorithm can provide better performance when the target network contains coregulated and interactively regulated genes.
The global distribution of fatal pesticide self-poisoning: Systematic review
Creators: name: Gunnell, David
name: Eddleston, Michael
name: Phillips, Michael R.
name: Konradsen, Flemming
Publisher: name: Columbia University
Year: 2007
Subjects: Pesticides
Suicide
Public health
Epidemiology

description: Background: Evidence is accumulating that pesticide self-poisoning is one of the most commonly used methods of suicide worldwide, but the magnitude of the problem and the global distribution of these deaths is unknown. Methods: We have systematically reviewed the worldwide literature to estimate the number of pesticide suicides in each of the World Health Organisation's six regions and the global burden of fatal self-poisoning with pesticides. We used the following data sources: Medline, EMBASE and psycINFO (1990–2007), papers cited in publications retrieved, the worldwide web (using Google) and our personal collections of papers and books. Our aim was to identify papers enabling us to estimate the proportion of a country's suicides due to pesticide self-poisoning. Results: We conservatively estimate that there are 258,234 (plausible range 233,997 to 325,907) deaths from pesticide self-poisoning worldwide each year, accounting for 30% (range 27% to 37%) of suicides globally. Official data from India probably underestimate the incidence of suicides; applying evidence-based corrections to India's official data, our estimate for world suicides using pesticides increases to 371,594 (range 347,357 to 439,267). The proportion of all suicides using pesticides varies from 4% in the European Region to over 50% in the Western Pacific Region but this proportion is not concordant with the volume of pesticides sold in each region; it is the pattern of pesticide use and the toxicity of the products, not the quantity used, that influences the likelihood they will be used in acts of fatal self-harm. Conclusion: Pesticide self-poisoning accounts for about one-third of the world's suicides. Epidemiological and toxicological data suggest that many of these deaths might be prevented if (a) the use of pesticides most toxic to humans was restricted, (b) pesticides could be safely stored in rural communities, and (c) the accessibility and quality of care for poisoning could be improved.