Additional file 1 of Long-term exposure to exogenous phthalate, masculinity and femininity trait, and gender identity in children: a Chinese 3-year longitudinal cohort study
Creators: name: Liu, Jieyu
name: Gao, Di
name: Wang, Huan
name: Li, Yanhui
name: Chen, Manman
name: Ma, Qi
name: Wang, Xinxin
name: Cui, Mengjie
name: Chen, Li
name: Zhang, Yi
name: Guo, Tongjun
name: Yuan, Wen
name: Ma, Tao
name: Jiang, Jianuo
name: Dong, Yanhui
name: Zou, Zhiyong
name: Ma, Jun
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary File: Table S1. Detailed parameters of PAEs metabolites detection. Table S2. Intraclass Correlation Coefficients for the repeated measurement data of different visits. Table S3. The masculine or feminine options in the Chinese version of Children’s Sex Role Inventory (CSRI) scale. Table S4. The results of Goodness-of-Fit test (Hosmer-Lemeshow test). Table S5. Characteristic of the baseline pediatric population from the longitudinal cohort study in China. Table S6. The concentration of phthalate metabolites and detection rate in boys and girls. Table S7. The concentration of phthalate metabolites and detection rate in boys and girls in three groups. Table S8. Approximate analysis of deviance using smoothing model analysis for the total PAEs exposure and the gender indentity scores in visit 5. Table S9. Approximate analysis of deviance using smoothing model analysis for the total PAEs exposure and the difference of gender indentity scores between visit 1 and visit 5. Table S10. Log-binomial analyses of relationships between log-transformed phthalates exposure and gender identity in visit 5 in children. Table S11. Log-binomial analyses of relationships between log-transformed phthalates exposure and gender identity in visit 5 in children without early onset of puberty. Figure S1. The appropriate scaled normal density for log-transformed values of PAEs in boys and girls. Figure S2. Sex-specific distribution of gender trait scores and percentage of gender identity type (* referred to P &lt; 0.05; ** referred to P &lt; 0.01). Figure S3. The results of GAM for the total PAEs exposure and the gender indentity scores in visit 5 (A. Boys; B. Girls). Figure S4. Distribution of gender trait scores in boys and girls with earlier pubertal onset. (*referred to significant differences). Figure S5. Distribution of gender trait scores in boys and girls without early pubertal onset. (*referred to significant differences). Figure S6. Linear associations between long-term PAEs exposure and the masculinity trait and femininity trait scores in children without early pubertal onset. (*95%CI did not contain 0 referred to P &lt; 0.05.). Figure S7. The results of GAM for the total PAEs exposure and the difference of gender indentity scores between visit 1 and visit 5 (A. Boys; B. Girls). Figure S8. Distribution of the differences in gender trait scores between the visit 1 and the visit 5 in boys and girls with earlier pubertal onset. Figure S9. Distribution of the differences in gender trait scores between the visit 1 and the visit 5 and its associations with long-term PAEs exposures in boys and girls without early pubertal onset. (*95%CI did not contain 0 referred to P &lt; 0.05.). Figure S10. Linear associations between long-term PAEs exposure and the differences in gender trait scores between visit 1 and visit 5 in children with early pubertal onset. (Model was additionally adjusted for BMI. *95%CI did not contain 0 referred to P &lt;0.05.). Figure S11. Linear associations between long-term PAEs exposure and the differences in gender trait scores between visit 1 and visit 5 in children without early pubertal onset. (Model was additionally adjusted for BMI. *95%CI did not contain 0 referred to P &lt; 0.05.). Figure S12. Distribution of gender identity in boys and girls. (Blue referred to boys and red referred to girls). Figure S13. Distribution of four types of gender identity in children who entered puberty earlier. (Blue referred to boys and red referred to girls).