cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantitative revenue estimates and qualitative assessments of innovative fundraising sources for treating rare diseases in Colombia
Creators: name: Walton, Surrey
name: Mayorga, Wilson
name: Narváez, Angela Rodríguez
name: Chavez, Maria Alejandra
name: Guesguán, Natalia Cortés
name: Durango, Luis
name: Parada, Ludy Alexandra
Publisher: name: University of Illinois at Chicago
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Background: Like many developing countries, Colombia faces difficulties in financing health-care services as well as programs for health promotion and health education and there is evidence that its health-care system is underperforming. Objective: To provide evidence-based estimates of potential funding levels and assess the strengths, weaknesses, and viability of innovative funding mechanisms with a focus on treating rare diseases in Colombia. Methods: The strategy involved evidence-based projections of potential funding levels and a qualitative viability assessment using an expert panel. Results: Crowdfunding, corporate donation, and social impact bonds (SIBs) were deemed to be the most viable of numerous potential strategies. Expected funding levels over 10 years for rare diseases in Colombia from crowdfunding, corporate donations, and SIBs were roughly $7,200, $23,000, and $12,400, respectively. Conclusions: Based on the combination of projected funding potential along with expert consensus regarding viability and operability, crowdfunding, corporate donations, and SIBs, especially in combination, have the potential to substantially improve funding for vulnerable patient populations in Colombia.
Text Phylogeny
Creators: name: Marmerola, Guilherme D.
name: Oikawa, Marina
name: Zanoni Dias
name: Siome Goldenstein
name: Rocha, Anderson
Publisher: name: figshare
Year: 2016
Subjects: Applied Computer Science

description: Over the history of mankind, textual records change. Sometimes due to mistakes during transcription, sometimes on purpose, as a way to rewrite facts and reinterpret history. There are several classical cases, such as the logarithmic tables, and the transmission of antique and medieval scholarship. Today, text documents are largely edited and redistributed on the Web. Articles on news portals and collaborative platforms (such as Wikipedia), source code, posts on social networks, and even scientific publications or literary works are some examples in which textual content can be subject to changes in an evolutionary process. In this scenario, given a set of near-duplicate documents, it is worthwhile to find which one is the original and the history of changes that created the whole set. Such functionality would have immediate applications on news tracking services, detection of plagiarism, textual criticism, and copyright enforcement, for instance. However, this is not an easy task, as textual features pointing to the documents' evolutionary direction may not be evident and are often dataset dependent. Moreover, side information, such as time stamps, are neither always available nor reliable. In this paper, we propose a framework for reliably reconstructing text phylogeny trees, and seamlessly exploring new approaches on a wide range of scenarios of text reusage. We employ and evaluate distinct combinations of dissimilarity measures and reconstruction strategies within the proposed framework, and evaluate each approach with extensive experiments, including a set of artificial near-duplicate documents with known phylogeny, and from documents collected from Wikipedia, whose modifications were made by Internet users. We also present results from qualitative experiments in two different applications: text plagiarism and reconstruction of evolutionary trees for manuscripts (stemmatology).Publication: On the Reconstruction of Text Phylogeny Trees: Evaluation and Analysis of Textual Relationships, 2016.
Text Phylogeny
Creators: name: Marmerola, Guilherme D.
name: Oikawa, Marina
name: Zanoni Dias
name: Siome Goldenstein
name: Rocha, Anderson
Publisher: name: figshare
Year: 2016
Subjects: Applied Computer Science

description: Over the history of mankind, textual records change. Sometimes due to mistakes during transcription, sometimes on purpose, as a way to rewrite facts and reinterpret history. There are several classical cases, such as the logarithmic tables, and the transmission of antique and medieval scholarship. Today, text documents are largely edited and redistributed on the Web. Articles on news portals and collaborative platforms (such as \emph{Wikipedia}), source code, posts on social networks, and even scientific publications or literary works are some examples in which textual content can be subject to changes in an evolutionary process. In this scenario, given a set of near-duplicate documents, it is worthwhile to find which one is the original and the history of changes that created the whole set. Such functionality would have immediate applications on news tracking services, detection of plagiarism, textual criticism, and copyright enforcement, for instance. However, this is not an easy task, as textual features pointing to the documents' evolutionary direction may not be evident and are often dataset dependent. Moreover, side information, such as time stamps, are neither always available nor reliable. In this paper, we propose a framework for reliably reconstructing text phylogeny trees, and seamlessly exploring new approaches on a wide range of scenarios of text reusage. We employ and evaluate distinct combinations of dissimilarity measures and reconstruction strategies within the proposed framework, and evaluate each approach with extensive experiments, including a set of artificial near-duplicate documents with known phylogeny, and from documents collected from Wikipedia, whose modifications were made by Internet users. We also present results from qualitative experiments in two different applications: text plagiarism and reconstruction of evolutionary trees for manuscripts (stemmatology).
T4I2016 - Barradas, Manuel; Joseph Carol; Milliken, Neil; Sharpe, Mark (2016): Modifications to a Customer Relationship Management (CRM) database system to enable the use of speech recognition software
Creators: name: Barradas, Manuel
name: Joseph, Carol
name: Milliken, Neil
name: Sharpe, Mark
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 80399 Computer Software not elsewhere classified
subject: FOS: Computer and information sciences
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 80505 Web Technologies (excl. Web Search)
subject: 80704 Information Retrieval and Web Search
subject: FOS: Media and communications
subject: 80404 Markup Languages
subject: 100602 Input, Output and Data Devices
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Barradas, Manuel; Joseph Carol; Milliken, Neil; Sharpe, Mark (2016): Modifications to a Customer Relationship Management (CRM) database system to enable the use of speech recognition software. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. Adding Accessible Rich Internet Applications (ARIA) HTML elements to web pages enables users to use speech recognition software for data entry and retrieval of information on databases. This in turn minimises the use of the keyboard and mouse which in turn can lead to less repetitive strain injury.
T4I2016 - Broglia, Emma; Millings, Abigail; Barkham, Michael: Therapist experiences of supplementing counselling with guided use of a well-being mobile phone app
Creators: name: Broglia, Emma
name: Millings, Abigail
name: Barkham, Michael
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 80502 Mobile Technologies
subject: FOS: Computer and information sciences
subject: 111710 Health Counselling
subject: 170106 Health, Clinical and Counselling Psychology
subject: FOS: Psychology
subject: Health Care

description: Broglia, Emma; Millings, Abigail; Barkham, Michael: Therapist experiences of supplementing counselling with guided use of a well-being mobile phone app. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. This article presents findings from a focus group exploring therapist’s experiences of supplementing counselling with guided use of a well-being app in a student counselling setting. Preliminary findings address the implementation, acceptability, usage, and potential implications described during the therapist focus group.
T4I2016 - Boyle, Bryan; Arnedillo-Sanchez, Inmaculada; Zahid, Aejaz: Designing collaborative virtual environments for children on the Autism Spectrum
Creators: name: Boyle, Bryan
name: Arnedillo-Sanchez, Inmaculada
name: Aejaz Zahid
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 120302 Design Innovation
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120403 Engineering Design Methods
subject: FOS: Other engineering and technologies

description: Boyle, Bryan; Arnedillo-Sanchez, Inmaculada; Zahid, Aejaz: Designing collaborative virtual environments for children on the Autism Spectrum. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. This paper outlines the examination of a Collaborative Virtual Environment (CVE) as a computer aided learning tool for children with symptoms typically associated with a diagnosis at the moderate to severe side of the autism spectrum. A CVE was co-designed with children with autism, their parents, teachers and other caregivers.
T4I2016 - Darley, Sally: Novel Navigation of an Alternative and Augmentative Communication Device
Creators: name: Darley, Sally
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: Health Care

description: Darley, Sally: Novel Navigation of an Alternative and Augmentative Communication Device. T4I Communications 1, T4I2016 – Non-research, Nov 2016. Figshare. This single case report summarises an innovative solution used to overcome the access challenges faced by a person with both physical and sensory impairments to use an AAC device. The authors infer issues to be considered more generally for communication aid provision for people in this population.
T4I2016 - Fitzgerald, Neil: Advanced switches and other new developments in access
Creators: name: Fitzgerald, Neil
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 100602 Input, Output and Data Devices
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: Computer Engineering
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 100699 Computer Hardware not elsewhere classified

description: Fitzgerald, Neil: Advanced switches and other new developments in access. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. This presentation will highlight available EMG and head pointing products suitable for computer access. It will also cover advanced features in Grid 3 which can help with Touch access, voice recognition and environment control. Smart box is a commercial supplier of the products described.
T4I2016 - Draffan, EA; Wald , M; Ahmad, A.I.; Kadous, A.; Zeinoun, N; Banes , D.; Sabia, O.; Lawand, D.: Personalise, Localise and Globalise: Symbols to enhance independent Communication
Creators: name: E.A. Draffan
name: Wald, Mike
name: A.I. Ahmad
name: A. Kadous
name: N. Zeinoun
name: Banes, David
name: O. Sabia
name: D. Lawand
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 200318 Middle Eastern Languages
subject: FOS: Languages and literature
subject: 200399 Language Studies not elsewhere classified
subject: 209999 Language, Communication and Culture not elsewhere classified
subject: 100599 Communications Technologies not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Draffan, EA; Wald , M; Ahmad, A.I.; Kadous, A.; Zeinoun, N; Banes , D.; Sabia, O.; Lawand, D.: Personalise, Localise and Globalise: Symbols to enhance independent Communication. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. This research explored the personal preferences of AAC users and those supporting them, in their need to have localised, cultural and religious symbols, that could be used alongside those already found on communication charts in certain multilingual settings.
T4I2016 - Gillham, Michael: Developing Effective Intelligent Assistance for the Powered Wheelchair User
Creators: name: Gillham, Michael
name: Garath Howells
name: Pepper, Matthew
name: Kelly, Steve
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 100602 Input, Output and Data Devices
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Gillham, Michael: Developing Effective Intelligent Assistance for the Powered Wheelchair User. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. This research is working towards developing a pre-production prototype system which can provide a low-cost real-time adjustable and adaptable driving assistance system for powered wheelchair users. Information is being gathered from user joystick input and their driving quality to identify symptoms and make adjustments to the driving assistance system.
T4I2016 - Hall, Darren: EyeGaze Case Report
Creators: name: Hall, Darren
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: Health Care

description: Hall, Darren: EyeGaze Case Report. T4I Communications 1, T4I2016 – Non-research, Nov 2016. Figshare. This Case report outlines the reasoning behind the provision of an EyeGaze system and the design of a custom mounting bracket for a client with Motor Neuron Disease (MND). The manufacture of the special bracket is outlined.
T4I2016 - Hewett, Paul; Wade, Will: Open Design: a proposed web service to facilitate sharing of hardware and software solutions in assistive technology
Creators: name: Hewett, Paul
name: Wade, Will
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 80505 Web Technologies (excl. Web Search)
subject: FOS: Computer and information sciences
subject: 80704 Information Retrieval and Web Search
subject: FOS: Media and communications
subject: 80306 Open Software
subject: 80309 Software Engineering
subject: Computer Software

description: Hewett, Paul; Wade, Will: Open Design: a proposed web service to facilitate sharing of hardware and software solutions in assistive technology. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. A proposal for a web portal will be presented that enables assistive technology projects (both hardware and software), in particular those which are open source, to be collated easily. It enables projects from multiple sources to be searched and located. Design4Us Lab Ltd is a design consultancy operating in the AT field. The ACE centre offers expert services in Augmentative and Alternative Communication and AT.
T4I2016 - James, Abi; Draffan, E.A.; Cudd, Peter; Bentley, Claire: Terminology, understanding AT and practice
Creators: name: Abi James
name: E.A. Draffan
name: Cudd, Peter
name: Bentley, Claire
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: 160508 Health Policy
subject: FOS: Political science
subject: 160511 Research, Science and Technology Policy

description: James, Abi; Draffan, E.A.; Cudd, Peter; Bentley, Claire: Terminology, understanding AT and practice. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. A workshop explored common challenges to assistive technology practice across a wide range of service providers and AT disciplines. The authors examine whether a lack of common terminology was hindering cross-sector cooperation.
T4I2016 - James, Abi; Cliffe , Emma; Dyer, Jennifer : STEM Enable: improving STEM accessibility through knowledge sharing
Creators: name: Abi James
name: Cliffe, Emma
name: Dyer, Jennifer
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: Science Policy
subject: 160508 Health Policy
subject: FOS: Political science
subject: 160511 Research, Science and Technology Policy
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering

description: James, Abi; Cliffe , Emma; Dyer, Jennifer : STEM Enable: improving STEM accessibility through knowledge sharing. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. This session will briefly introduce Science, Technology, Engineering and Mathematics (STEM) accessibility issues before considering the potential impact of crowd-sourcing Assistive Technology (AT) knowledge on professional skills and the development of new technologies in other AT fields.
T4I2016 - Judge, Simon; Nasr, Nasrin; Hawley, Mark: The potential application of EMG as assistive technology: a usability study
Creators: name: Judge, Simon
name: Nasr, Nasrin
name: Hawley, Mark
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 120399 Design Practice and Management not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: Health Care

description: Judge, Simon; Nasr, Nasrin; Hawley, Mark: The potential application of EMG as assistive technology: a usability study. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. The aim of this study is to examine the potential for the use of a new type of EMG sensor in assistive applications with the end goal of developing an EMG switch that can be placed on the market and used by individuals as an assistive control method.
T4I2016 - Kirton, Andrea; Darley, Sally: Simplicity is the Ultimate Sophistication
Creators: name: Kirton, Andrea
name: Darley, Sally
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: Disability Studies
subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: 170202 Decision Making
subject: FOS: Psychology
subject: 120399 Design Practice and Management not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120403 Engineering Design Methods
subject: FOS: Other engineering and technologies
subject: Health Care

description: Kirton, Andrea; Darley, Sally: Simplicity is the Ultimate Sophistication. T4I Communications 1, T4I2016 – Non-research, Nov 2016. Figshare. The authors have observed, complex technological solutions are often explored but the complexity of these solutions may actually become a burden or barrier either to the user or their support network. In these cases, simpler solutions, which may have been overlooked, may provide a more effective option.
T4I2016 - Murphy, Joan: Digital Talking Mats: a tool to enhance communication
Creators: name: Murphy, Joan
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 110321 Rehabilitation and Therapy (excl. Physiotherapy)
subject: FOS: Clinical medicine
subject: Health Care

description: Murphy, Joan: Digital Talking Mats: a tool to enhance communication. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. This presentation will explain the background to Talking Mats and the journey from a low-tech method to a digital tool. The tool is now being used widely with people of all ages and abilities across the world. Talking Mats is a product of the social enterprise Talking Mats Ltd.
T4I2016 - Moseley, Mark: The use of technology to provide physical interaction experiences for cognitively able young people who have complex physical disabilities
Creators: name: Moseley, Mark
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90305 Rehabilitation Engineering
subject: FOS: Medical engineering
subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: Health Care

description: Moseley, Mark: The use of technology to provide physical interaction experiences for cognitively able young people who have complex physical disabilities. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. This study aims to develop a tool incorporating an eye gaze controlled robotic arm that provides haptic feedback, to enable young people who have severe physical disabilities and good cognition to experience simulated physical manipulation of objects, and simple play.
T4I2016 - O’Neill, Peter; Kirton, Andrea; Prescott, Ste: DrawTalk, an alternative input method for an AAC
Creators: name: O'Neill, Peter
name: Kirton, Andrea
name: Ste Prescott
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 209999 Language, Communication and Culture not elsewhere classified
subject: FOS: Languages and literature
subject: 100599 Communications Technologies not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: Health Care

description: O’Neill, Peter; Kirton, Andrea; Prescott, Ste: DrawTalk, an alternative input method for an AAC. T4I Communications 1, T4I2016 – Academic/Research, Nov 2016. Figshare. Drawing to communicate goes back to the cave man times. An Assistive Technology Professional suggested its use within an Augmentative Alternative Communication aid (AAC). University course students implemented this in an alternative method of user input. The technological image recognition limitations did not allow useful evaluation.
title: The Future of Scientific Data
title: A personal account returning to the heart of science – and presenting strategies and tools for dealing with data
titleType: Subtitle
Creators: name: Biskup, Till
Publisher: name: Zenodo
Year: 2024

description: Generating research data has become pretty cheap in many cases, hence the amount of research data created grows at least exponentially in the last years. However, our (mental) tools to deal with this tremendously growing amount of data did not develop nearly in the same pace. Hence we are often drowned with data. Even worse: there is no easy way to determine nor ensure the quality of data. On the other hand, dealing with data is nothing new, but intrinsic to the scientific method since centuries. Starting with the question: What is this thing called science? and a short overview of the research data life cycle, two tools for specific aspects, namely the ASpecD framework for fully reproducible data analysis and the Infofile for recording sufficiently complete metadata during data acquisition are presented. Eventually, the answer to the question raised in the talk is: It’s the way you are dealing with (our) data. For our future self – and science itself.
T4I2016 - Lee, Steve: Stepping Stones for people with cognitive disabilities and low digital literacy
Creators: name: Lee, Steve
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 80306 Open Software
subject: FOS: Computer and information sciences
subject: 80505 Web Technologies (excl. Web Search)

description: Lee, Steve: Stepping Stones for people with cognitive disabilities and low digital literacy. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. The software components presented have been designed to allow people with cognitive disabilities and low digital literacy to easily perform common on-line activities. The components are managed as an open source project to encourage wide contribution and engender innovation. OpenDirective Ltd is dedicated to facilitating open innovation in accessibility and assistive technology.
T4I2016 - Purdham, Stephen: My Favourite things: The emerging IoT and the impacts that are expected in Social care in the Technology adoption of Multi-Platform AT elements
Creators: name: Purdham, Stephen
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: Health Care
subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Purdham, Stephen: My Favourite things: The emerging IoT and the impacts that are expected in Social care in the Technology adoption of Multi-Platform AT elements. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. This presentation will look at the potential impact that the expected 50 billion things connected to the Internet by 2020 could have on social care. Building on experiences gained with the 3rings patented Plug & platform in creating distributed family care. Chairman of 3rings Care Ltd and named co-inventor of 3rings Plug and Platform patent.
T4I2016 - Redmond, Emily; French, Tom: Disabled people crossing the digital divide: Supporting independence with digital skills in the community
Creators: name: Redmond, Emily
name: French, Tom
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 111703 Care for Disabled
subject: FOS: Health sciences
subject: Digital Humanities
subject: 160512 Social Policy
subject: FOS: Political science
subject: 111708 Health and Community Services
subject: 130101 Continuing and Community Education
subject: FOS: Educational sciences
subject: 160702 Counselling, Welfare and Community Services
subject: FOS: Sociology

description: Redmond, Emily; French, Tom: Disabled people crossing the digital divide: Supporting independence with digital skills in the community. T4I Communications 1, T4I2016 – Knowledge Transfer, Nov 2016. Figshare. This presentation focuses on research undertaken with community organisations which support disabled people, to find out about the barriers to digital inclusion facing this audience. The research will inform a practical handbook to help such organisations get disabled people online. Tinder Foundation manages the 5,000 strong UK online centres network which supports people to gain digital skills in communities across the country.
MPEC 2024-L104 : 2024 LR2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 LR2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Radical right voters’ grievances over immigration, feminism and LGBTQI+ rights
Creators: name: Off, Gefjon
Publisher: name: Eurac Research
Year: 2024

description: Radical right parties across Europe have mobilized against different feminist goals. How are these party positions reflected in the electorate? The example of voters of the radical right Alternative for Germany (AfD) shows why cultural grievances about immigration, feminism and LGBTQI+ issues should be studied in combination.
The breadwinner and “the other”: sexism, immigrant economic threat, and support for immigration restriction in American Public Opinion
Creators: name: Filindra, Alexandra
Publisher: name: University of Illinois at Chicago
Year: 2024

description: We offer a theory that links sexism to economic threat from immigrants and immigration-related policy preferences. Sexism has generally been associated with vote choice and other policy preferences but has not been studied in the context of immigration. We argue that because sexists are concerned with maintaining gender hierarchies, they tend to be threatened by the perceived effects of immigrants on jobs, which can upset native men’s breadwinning ability and social status. Therefore, we expect that individuals scoring high on sexism are more likely to believe that immigrants are an economic threat and to support policies that make immigration harder and thus alleviate such a threat. We specify regression analyses and lagged dependent variable (LDV) models using data from two national datasets, the 2016 ANES, and the 2016–2018 Voter Study Group (VSG) panel. We find that controlling for known predictors, sexism is a significant driver of immigrant economic threat and support for immigration restrictions among white Americans. Results among nonwhites are mixed but tend to support our theory. We also find that the effect of sexism is not conditional upon the respondent’s gender. Lagged dependent variable models further strengthen our inferences, alleviating endogeneity concerns. Our analyses suggest a link between sexism and immigrant economic threat, suggesting that sexist Americans may perceive immigration as a threat to the economic status of men.
Supplementary Material for: CBT4BN: A Randomized Controlled Trial of Online Chat and Face-to-Face Group Therapy for Bulimia Nervosa
Creators: name: Zerwas, S.C.
name: Watson, H.J.
name: Hofmeier, S.M.
name: Levine, M.D.
name: Hamer, R.M.
name: Crosby, R.D.
name: Runfola, C.D.
name: Peat, C.M.
name: Shapiro, J.R.
name: Zimmer, B.
name: Moessner, M.
name: Kordy, H.
name: Marcus, M.D.
name: Bulik, C.M.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Objective: Although cognitive-behavioral therapy (CBT) represents the first-line evidence-based psychotherapy for bulimia nervosa (BN), most individuals seeking treatment do not have access to this specialized intervention. We compared an Internet-based manualized version of CBT group therapy for BN conducted via a therapeutic chat group (CBT4BN) to the same treatment conducted via a traditional face-to-face group therapy (CBTF2F). Method: In a two-site, randomized, controlled noninferiority trial, we tested the hypothesis that CBT4BN would not be inferior to CBTF2F. A total of 179 adult patients with BN (2.6% males) received up to 16 sessions of group CBT over 20 weeks in either CBT4BN or CBTF2F, and outcomes were compared at the end of treatment and at the 12-month follow-up. Results: At the end of treatment, CBT4BN was inferior to CBTF2F in producing abstinence from binge eating and purging. However, by the 12-month follow-up, CBT4BN was mostly not inferior to CBTF2F. Participants in the CBT4BN condition, but not CBTF2F, continued to reduce their binge-eating and purging frequency from the end of treatment to the 12-month follow-up. Conclusions: CBT delivered online in a group chat format appears to be an efficacious treatment for BN, although the trajectory of recovery may be slower than face-to-face group therapy. Online chat groups may increase accessibility of treatment and represent a cost-effective approach to service delivery. However, barriers in service delivery such as state-specific license and ethical guidelines for online therapists need to be addressed.
Entry, growth and survival in the green industry
Creators: name: Dakshina G. De Silva
name: Hubbard, Timothy P.
name: McComb, Robert P.
name: Schiller, Anita R.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Entry, growth and survival in the green industry. Regional Studies. Economists are interested in the factors that induce firm entry, lead to growth and help firms succeed in various markets. Such information can be helpful to policy-makers, but, unfortunately, such patterns have not been considered for ‘green industries’. This paper takes advantage of a recent definition of green industries proposed by the US Bureau of Labor Statistics (BLS) to investigate patterns characterizing these industries within the State of Texas.
Ultrafast X-ray Absorption Spectroscopy Reveals Excited State Dynamics of B12 Coenzymes Controlled by the Axial Base
Creators: name: Chung, Taewon
name: McClain, Taylor P.
name: Alonso-Mori, Roberto
name: Chollet, Matthieu
name: Deb, Aniruddha
name: Garcia-Esparza, Angel T.
name: Huang, Joel Ze En
name: Lamb, Ryan M.
name: Michocki, Lindsay B.
name: Reinhard, Marco
name: Van Driel, Tim B.
name: Penner-Hahn, James E.
name: Sension, Roseanne J.
Publisher: name: American Chemical Society
Year: 2023
Subjects: subject: Chemistry
subject: Science

description: Polarized time-resolved X-ray absorption spectroscopy at the Co K-edge is used to probe the excited state dynamics and photolysis of base-off methylcobalamin and the excited state structure of base-off adenosylcobalamin. For both molecules, the final excited state minimum shows evidence for an expansion of the cavity around the Co ion by ca. 0.04 Å to 0.05 Å. The 5-coordinate base-off cob(II)alamin that is formed following photodissociation is has a structure similar to that of 5-coordinate base-on cob(II)alamin, with a ring expansion of 0.03 Å to 0.04 Å and a contraction of the bond to the the lower axial  ligand bond length relative to that in the 6-coordinate ground state. These data provide insights into the role of the lower axial ligand in modulating the reactivity of B12 coenzymes
No degeneration found in focal cartilage defects evaluated with dGEMRIC at 12-year follow-up
Creators: name: Engen, Cathrine Nørstad
name: Løken, Sverre
name: Årøen, Asbjørn
name: Ho, Charles
name: Engebretsen, Lars
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Background and purpose — The natural history of focal cartilage defects (FCDs) is still unresolved, as is the long-term cartilage quality after cartilage surgery. It has been suggested that delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a biomarker of early OA. We aimed to quantitatively evaluate the articular cartilage in knees with FCDs, 12 years after arthroscopic diagnosis. Patients and methods — We included 21 patients from a cohort of patients with knee pain who underwent arthroscopy in 1999. Patients with a full-thickness cartilage defect, stable knees, and at least 50% of both their menisci intact at baseline were eligible. 10 patients had cartilage repair performed at baseline (microfracture or autologous chondrocyte implantation), whereas 11 patients had either no additional surgery or simple debridement performed. Mean follow-up time was 12 (10–13) years. The morphology and biochemical features were evaluated with dGEMRIC and T2 mapping. Standing radiographs for Kellgren and Lawrence (K&L) classification of osteoarthritis (OA) were obtained. Knee function was assessed with VAS, Tegner, Lysholm, and KOOS. Results — The dGEMRIC showed varying results but, overall, no increased degeneration of the injured knees. Degenerative changes (K&L above 0) were, however, evident in 13 of the 21 knees. Interpretation — The natural history of untreated FCDs shows large dGEMRIC variations, as does the knee articular cartilage of surgically treated patients. In this study, radiographic OA changes did not correlate with cartilage quality, as assessed with dGEMRIC.
Functional marine metagenomic screening for anti-quorum sensing and anti-biofilm activity
Creators: name: Yaniv, Karin
name: Golberg, Karina
name: Esti Kramarsky-Winter
name: Marks, Robert
name: Pushkarev, Alina
name: Béjà, Oded
name: Kushmaro, Ariel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Quorum sensing (QS), a cell-to-cell communication process, entails the production of signaling molecules that enable synchronized gene expression in microbial communities to regulate myriad microbial functions, including biofilm formation. QS disruption may constitute an innovative approach to the design of novel antifouling and anti-biofilm agents. To identify novel quorum sensing inhibitors (QSI), 2,500 environmental bacterial artificial chromosomes (BAC) from uncultured marine planktonic bacteria were screened for QSI activity using soft agar overlaid with wild type Chromobacterium violaceum as an indicator. Of the BAC library clones, 7% showed high QSI activity (>40%) against the indicator bacterium, suggesting that QSI is common in the marine environment. The most active compound, eluted from BAC clone 14-A5, disrupted QS signaling pathways and reduced biofilm formation in both Pseudomonas aeruginosa and Acinetobacter baumannii. The mass spectra of the active BAC clone (14-A5) that had been visualized by thin layer chromatography was dominated by a m/z peak of 362.1.
The AO Pediatric Comprehensive Classification of Long Bone Fractures (PCCF)
Creators: name: Joeris, Alexander
name: Lutz, Nicolas
name: Blumenthal, Andrea
name: Slongo, Theddy
name: Audigé, Laurent
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Background and purpose — To achieve a common understanding when dealing with long bone fractures in children, the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO PCCF) was introduced in 2007. As part of its final validation, we present the most relevant fracture patterns in the upper extremities of a representative population of children classified according to the PCCF. Patients and methods — We included children and adolescents (0–17 years old) diagnosed with 1 or more long bone fractures between January 2009 and December 2011 at the university hospitals in Bern and Lausanne (Switzerland). Patient charts were retrospectively reviewed and fractures were classified from standard radiographs. Results — Of 2,292 upper extremity fractures in 2,203 children and adolescents, 26% involved the humerus and 74% involved the forearm. In the humerus, 61%, and in the forearm, 80% of single distal fractures involved the metaphysis. In adolescents, single humerus fractures were more often epiphyseal and diaphyseal fractures, and among adolescents radius fractures were more often epiphyseal fractures than in other age groups. 47% of combined forearm fractures were distal metaphyseal fractures. Only 0.7% of fractures could not be classified within 1 of the child-specific fracture patterns. Of the single epiphyseal fractures, 49% were Salter-Harris type-II (SH II) fractures; of these, 94% occurred in schoolchildren and adolescents. Of the metaphyseal fractures, 58% showed an incomplete fracture pattern. 89% of incomplete fractures affected the distal radius. Of the diaphyseal fractures, 32% were greenstick fractures. 24 Monteggia fractures occurred in pre-school children and schoolchildren, and 2 occurred in adolescents. Interpretation — The pattern of pediatric fractures in the upper extremity can be comprehensively described according to the PCCF. Prospective clinical studies are needed to determine its clinical relevance for treatment decisions and prognostication of outcome.
The AO Pediatric Comprehensive Classification of Long Bone Fractures (PCCF)
Creators: name: Joeris, Alexander
name: Lutz, Nicolas
name: Blumenthal, Andrea
name: Slongo, Theddy
name: Audigé, Laurent
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Background and purpose — To achieve a common understanding when dealing with long bone fractures in children, the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO PCCF) was introduced in 2007. As part of its final validation, we present the most relevant fracture patterns in the lower extremities of a representative population of children classified according to the PCCF. Patients and methods — We included patients up to the age of 17 who were diagnosed with 1 or more long bone fractures between January 2009 and December 2011 at either of 2 tertiary care university hospitals in Switzerland. Patient charts were retrospectively reviewed. Results — More lower extremity fractures occurred in boys (62%, n = 341). Of 548 fractured long bones in the lower extremity, 25% involved the femur and 75% the lower leg. The older the patients, the more combined fractures of the tibia and fibula were sustained (adolescents: 50%, 61 of 123). Salter-Harris (SH) fracture patterns represented 66% of single epiphyseal fractures (83 of 126). Overall, 74 of the 83 SH patterns occurred in the distal epiphysis. Of all the metaphyseal fractures, 74 of 79 were classified as incomplete or complete. Complete oblique spiral fractures accounted for 57% of diaphyseal fractures (120 of 211). Of all fractures, 7% (40 of 548) were classified in the category "other", including 29 fractures that were identified as toddler’s fractures. 5 combined lower leg fractures were reported in the proximal metaphysis, 40 in the diaphysis, 26 in the distal metaphysis, and 8 in the distal epiphysis. Interpretation — The PCCF allows classification of lower extremity fracture patterns in the clinical setting. Re-introduction of a specific code for toddler’s fractures in the PCCF should be considered.
Dimdazenil: First Approval
Creators: name: Syed, Yahiya Y.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description:   
Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable
Additional information about this Adis Drug Review can be found here
Abstract
Dimdazenil (Junoenil®) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)A receptor that is being developed by Zhejiang Jingxin Pharmaceutical in collaboration with Evotec for the treatment of insomnia. Dimdazenil is designed to overcome issues associated with full GABAA receptor agonists, such as tolerance, withdrawal symptoms and associated adverse effects. On 29 November 2023, dimdazenil oral capsules received approval in China for the short-term treatment of insomnia. This article summarizes the milestones in the development of dimdazenil leading to this first approval for insomnia.
© Springer Nature Switzerland AG 2024
Cationic solid lipid nanoparticles (SLN) complexed with plasmid DNA enhance prostate cancer cells (PC-3) migration
Creators: name: Garcia-Fossa, Fernanda
name: de Jesus, Marcelo Bispo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Nanotechnology applications in biomedicine have increased in recent decades, primarily as therapeutic agents, drugs, and gene delivery systems. Among the nanoparticles used in medicine, we highlight cationic solid lipid nanoparticles (SLN). Given their nontoxic properties, much research has focused on the beneficial effects of SLN for drug or gene delivery system. However, little attention has been paid to the adverse impacts of SLN on the cellular environment, particularly their influence on intracellular signaling pathways. In this work, we investigate the effects triggered by cationic SLN on human prostate non-tumor cells (PNT1A) and tumor cells (PC-3). Our results demonstrate that cationic SLN enhances the migration of PC-3 prostate cancer cells but not PNT1A non-tumor prostate cells, an unexpected and unprecedented development. Furthermore, we observed that the enhanced cell migration velocity is a concentration-dependent and nanoparticle-dependent effect, and not related to any individual nanoparticle component. Moreover, cationic SLN increased vimentin expression (p < 0.05) but SLN did not affect Smad2 nuclear translocation. Meanwhile, EMT-related (epithelial-to-mesenchymal transition) proteins, such as ZEB1, underwent nuclear translocation when treated with cationic SLN, thereby affecting PC-3 cell motility through ZEB1 and vimentin modulation. From a therapeutic perspective, cationic SLN could potentially worsen a patient’s condition if these results were reproduced in vivo. Understanding the in vitro molecular mechanisms triggered by nanomaterials and their implications for cell function is crucial for defining their safe and effective use.