cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Acceptance and Commitment Therapy self-help intervention for depression in haemodialysis patients: a feasibility randomised controlled trial
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C800 - Psychology

description: Objective: People with end-stage renal disease (ESRD) experience high rates of depression and this is associated with poorer health-related outcomes. Acceptance and Commitment Therapy (ACT) has shown promising results in a number of long-termconditions and has been translated into a variety of self-help formats. We aimed to determine the feasibility of a trial examining telephone-supported self-help based on ACT for individuals with ESRD who experience depression. A brief and extended account of theresearch is provided. This is preceded by a systematic literature review examining whether ACT interventions can improve quality of life in long-term physical conditions (see section for more information). Design: A feasibility randomised controlled trial comparing telephone-supported ACT self-help with treatment as usual. Methods: Participants were recruited from four outpatient haemodialysis units acrossNottinghamshire, UK. The Patient Health Questionnaire (PHQ-9), EuroQol (EQ-5D-5L) health-related quality of life measure, Acceptance and Action Questionnaire II (AAQ-II) andValued Living Questionnaire (VLQ) were completed at baseline and 2- and 4-months post-randomisation. Participants in the intervention arm were asked to complete an ACT self-helpmanual over six weeks with weekly telephone support. Following completion of the trial, six participants were interviewed to examine the acceptability of the trial procedure and intervention. Interview data was analysed using framework analysis. Results: In total, 99 (36.87%) of 276 screening questionnaires were returned. Of these, 30 (30.3%) met the cut-off for depression on the PHQ-9 with nine enrolling in the trial. AAQ-II scores of screened participants were positively associated with scores on the PHQ-9 and GAD-7, indicating a positive relationship between psychological inflexibility and distress.Interview data indicated that the recruitment and randomisation procedure, and assessment methods were acceptable. Only one in four of the participants in the ACT arm of the trial completed all chapters of the book with health problems the main barrier to completion. Conclusion: Our findings indicate that a definitive trial examining the effectiveness of a telephone-supported ACT self-help intervention would not be feasible. Many aspects of thetrial were acceptable to participants, including the main recruitment strategy, randomisation procedure and data collection methods. However, low recruitment numbers and poor adherence to the self-help manual indicate that a full-scale trial would not be viable. Factorsthat might account for low recruitment numbers are discussed and personal reflections on the research process are provided.
MyGene2 automated match report: TCTN2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for TCTN2.
Art und Entstehung der wenig bekannten Mineralwässer des Landkreises Öhringen
Creators: name: Carlé, Walter
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
MyGene2 automated match report: AVPR2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for AVPR2.
MyGene2 automated match report: KMT2D
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for KMT2D.
Epoxidation of Alkenes by Dimethyldioxirane:  Kinetics, Activation Parameters and Solvent Studies
Creators: name: Crow, Brian
Publisher: name: Georgia State University
Year: 2006

description: The reaction of dimethyldioxirane with a series of cis/trans-1,2-dialkylalkenes was carried out and produced the corresponding epoxides in high yield.  As expected, the relative reactivity at 23 §C of the cis-alkenes was at least 8-fold greater than that of the trans-counterparts with the magnitude of the relative reactivity increasing with increased steric bulk.  Enhanced selectivity for cis- versus trans-alkene epoxidation was observed at lower temperatures.  The reaction of dimethyldioxirane with selected alkenes was carried out in various solvent conditions (dried acetone:acetonitrile (1:9), dried acetone:methanol (1:9), dried acetone:carbon tetrachloride (1:9) and acetone:water (Xwater = 0.00, 0.01, 0.02, 0.03, 0.04, 0.05)) and produced the corresponding epoxides in high yield.  The reactivity of dioxirane with simple di- and trialkylalkenes was enhanced as the polarity and hydrogen bonding capability of the solvent system were increased.   Little to no change in reactivity was observed in the non-polar solvent system.  Epoxidation of trisubstituted alkenes by dioxirane showed a greater rate enhancement in polar protic solvents compared to that for the epoxidation of the disubstituted alkenes.  The epoxidation of an allylic alcohol by dimethyldioxirane showed a large increase in the non-polar solvent system compared to that in acetone.  The reaction of dimethyldioxirane with the allylic alcohol also exhibited less of a rate increase in polar protic systems than its alkyl counterpart.  Activation parameters for the epoxidation of cis/trans-1,2-dialkylalkenes by dioxirane in dried acetone and the previously mentioned solvent systems were determined using the Arrhenius method.  In general, the ?G? and ?H? terms were greater for the reaction of dimethyldioxirane with trans-alkenes as compared to those for the corresponding cis-isomers regardless of solvent or alkyl steric bulk.  The calculated ?S? terms appeared essentially independent of steric bulk or solvent composition and were roughly identical, within experimental error, for all of the five cis/trans pairs.  The ??G? values, a comparison of the trans- to the cis-isomer data, yielded values of 1.2 to 1.8 kcal/mol in dried acetone for the five pairs of alkenes and appeared to be dependent on relative steric interactions.  The ??G? values for the epoxidation of cis/trans-alkenes carried out in solvents other than acetone showed no change from the value obtained in acetone.  The experimental activation parameter data in dried acetone were consistent with predictions from ab initio calculations based on a spiro transition state model.
Neue Höhenschotterfunde auf dem Galgenberg bei Tübingen
Creators: name: Eißele, Konrad
name: Schädel, Karl
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
The development and evaluation of a brief self-practice Compassion-Focused Therapy (CFT) intervention as a precursor to treatment as usual (TAU) for trauma patients: a pilot randomised controlled trial (RCT).
Creators: name: Rycroft, Claire Michelle
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: Interview data indicated that the recruitment and randomisation procedure, and assessment methods were acceptable. Only one in four of the participants in the ACT arm of the trial completed all chapters of the book with health problems the main barrier to completion. Conclusion: Our findings indicate that a definitive trial examining the effectiveness of a telephone-supported ACT self-help intervention would not be feasible. Many aspects of thetrial were acceptable to participants, including the main recruitment strategy, randomisation procedure and data collection methods. However, low recruitment numbers and poor adherence to the self-help manual indicate that a full-scale trial would not be viable. Factorsthat might account for low recruitment numbers are discussed and personal reflections on the research process are provided.
MyGene2 automated match report: SQSTM1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for SQSTM1.
Supplementary material for publication: "Evolution of actors' network in Twitter discussions: the Dual VET case"
Creators: name: Barroso-Hurtado, Domingo
name: Arroyo-Machado, Wenceslao
name: Torres-Salinas, Daniel
Publisher: name: Zenodo
Year: 2020
Subjects: Twitter
FP Dual
social networks

description: Supplementary material for publication: "Evolution of actors’ network in Twitter discussions: the Dual VET case". These files include figures and tables.
The development and evaluation of a brief self-practice Compassion-Focused Therapy (CFT) intervention as a precursor to treatment as usual (TAU) for trauma patients: a pilot randomised controlled trial (RCT).
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C800 - Psychology

description: Interview data indicated that the recruitment and randomisation procedure, and assessment methods were acceptable. Only one in four of the participants in the ACT arm of the trial completed all chapters of the book with health problems the main barrier to completion. Conclusion: Our findings indicate that a definitive trial examining the effectiveness of a telephone-supported ACT self-help intervention would not be feasible. Many aspects of thetrial were acceptable to participants, including the main recruitment strategy, randomisation procedure and data collection methods. However, low recruitment numbers and poor adherence to the self-help manual indicate that a full-scale trial would not be viable. Factorsthat might account for low recruitment numbers are discussed and personal reflections on the research process are provided.
Data for paper "An objective functional characterisation of head movement impairment in individuals with neck muscle weakness due to Amyotrophic lateral sclerosis"
Creators: name: Pancani, Silvia
Publisher: name: The University of Sheffield
Year: 2016
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: Please refer to the Readme.docx file for information about the dataset.
These data were collected for a research project entitled "An objective functional characterisation of head movement impairment in individuals with neck muscle weakness due to Amyotrophic lateral sclerosis" published in PLOS ONE https://doi.org/10.1371/journal.pone.0169019.
Methods involved in generating the data are described in the paper.
Data are also included in the PhD thesis entitled "Assessing residual neck mobility when wearing a cervical orthosis: an application in patients with Motor Neurone Disease" which is available online through WREO http://etheses.whiterose.ac.uk/id/eprint/16179.
Development of Chiral/Achiral Analysis Methods using Capillary Electrochromatography and Capillary Electrochromatography Coupled to Mass Spectrometry
Creators: name: Zheng, Jie
Publisher: name: Georgia State University
Year: 2006

description: The research presented in this dissertation involves the development of chiral and achiral analysis using capillary electrochromatography (CEC) and CEC coupled to mass spectrometry (CEC-MS). Chapter 1 briefly reviews CEC fundamentals and latest development on chiral CEC and CEC-MS. The CEC-UV enantioseparations for several acidic compounds are described in Chapter 2. The optimum resolutions for these acidic enantiomers are achieved in ion-suppression mode, i.e. with an acidic mobile phase. One of major drawback in coupling CEC with MS is the bubble formation at the column outlet end, resulting in irreproducible retention time and erratic baseline, or even current breakdown. By introducing internal tapered columns, the aforementioned limitations of CEC-MS are successfully overcome in Chapter 3. The CEC-MS enantioseparation of warfarin and coumachlor is carefully investigated and applied to quantify R- and S-warfarin in human plasma. For individual enantiomers, a concentration of 25 ng/mL is detectable. To further improve the robustness of CEC-MS column, a new procedure of fabricating internal tapered columns is reported in Chapter 4. These internal tapered columns demonstrate excellent ruggedness, low background noise, and good compatibility in reversed-phase and polar organic modes of CEC-MS. In chapter 5, the feasibility of using internal tapered columns packed with vancomycin chiral stationary phase (CSP) is explored for simultaneous enantioseparation of eight ƒ-blockers using CEC-MS. After a careful optimization of the mobile phase composition, sheath liquid and spray chamber parameter, 15 out of 16 enantiomers could be simultaneously resolved with excellent efficiency and detection sensitivity. The synthesis and characterization of sulfated and sulfonated cellulose phenylcarbamate CSPs is described in Chapter 6. The use of these CSPs, especially the sulfonated one, significantly enhances the EOF profile and sample throughput but maintain high enantiomeric resolving power under various modes of CEC and CEC-MS. By combining CEC and atmospheric pressure photo-ionization (APPI) MS, Chapter 7 demonstrates the separation and detection of mono-methylated benzo[a]pyrene (MBAP) isomers with ~100 times enhancement on detection sensitivity than CEC-UV. In Appedix 2, monolithic columns are synthesized through photopolymerized sol-gel approach and utilized for CEC and CEC-APPI-MS of polyaromatic hydrocarbons, and alkyl phenyl ketones.
MyGene2 automated match report: TMEM216
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for TMEM216.
Verlust und Gewinn der Stuttgarter Flora im letzten Jahrhundert. Nachtrag 1957
Creators: name: Kreh, Wilhelm
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
title: GC. 9.4.7 - « Textes de morale »
Creators: name: Laleure, Pierre
name: Canguilhem, Georges (1904-1995)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022

description: fichier compressé
description: created: start=1930;end=1931
title: Machine Intelligence Showcase Report 2018
Creators: name: Kanza, Samantha
Publisher: name: University of Southampton
Year: 2019
Subjects: subject: AI3SD, Machine Intelligence, Event Report

description: This event was run by the Centre for Machine Intelligence (CMI) and was designed to be a showcase of the work that is being conducted in different areas of machine learning at the University of Southampton. This was the first event of its kind for the CMI as it was only launched earlier this year. This event was a full day showcase, hosted at the University of Southampton. The programme was made up of a number of presentations, ranging from AI for social good to robots. These were all run one after the other so it was possible to attend each talk. There was plenty of time for networking, as there was both a lunch and drinks session included as part of the day. Lunch was held during the poster session so attendees could eat and explore the range of posters displaying work from PhD students and Postdoctoral researchers in ECS relating to machine learning. There was also another opportunity to view posters later in the afternoon during the drinks session, and a specific âspeed datingâ session was held to facilitate students and postdoctoral researchers making contact with relevant companies and research organisations.
Die Blümleszunft, Leben und Arbeit in 30 Jahren
Creators: name: Kreh, Wilhelm
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
title: 01_0552
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Bestimmungstabellen für die Weiden im Gebiet des mittleren Neckars
Creators: name: Leidolf, Rudolf
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study
Creators: name: Lingzhen Dai
name: Mehta, Amar
name: Mordukhovich, Irina
name: Just, Allan C.
name: Jincheng Shen
name: Lifang Hou
name: Koutrakis, Petros
name: Sparrow, David
name: Pantel S. Vokonas
name: Baccarelli, Andrea A.
name: Schwartz, Joel D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Although there is growing evidence that exposure to ambient particulate matter is associated with global DNA methylation and gene-specific methylation, little is known regarding epigenome-wide changes in DNA methylation in relation to particles and, especially, particle components. Using the Illumina Infinium HumanMethylation450 BeadChip, we examined the relationship between one-year moving averages of PM2.5 species (Al, Ca, Cu, Fe, K, Na, Ni, S, Si, V, and Zn) and DNA methylation at 484,613 CpG probes in a longitudinal cohort that included 646 subjects. Bonferroni correction was applied to adjust for multiple comparisons. Bioinformatics analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment was also performed. We observed 20 Bonferroni significant (P-value < 9.4× 10−9) CpGs for Fe, 8 for Ni, and 1 for V. Particularly, methylation at Schlafen Family Member 11 (SLFN11) cg10911913 was positively associated with measured levels of all 3 species. The SLFN11 gene codes for an interferon-induced protein that inhibits retroviruses and sensitizes cancer cells to DNA-damaging agents. Bioinformatics analysis suggests that gene targets may be relevant to pathways including cancers, signal transduction, and cell growth and death. Ours is the first study to examine the epigenome-wide association between ambient particles species and DNA methylation. We found that long-term exposures to specific components of ambient particle pollution, especially particles emitted during oil combustion, were associated with methylation changes in genes relevant to immune responses. Our findings provide insight into potential biologic mechanisms on an epigenetic level.
Real-time measurement of size-resolved elemental composition ratio for flame synthesized composite nanoparticle aggregates using a tandem SMPS-ICP-OES
Creators: name: Reed, Nathan
name: Jiaxi Fang
name: Sanmathi Chavalmane
name: Pratim Biswas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: Composite nanoparticles find application in catalysis, drug delivery, and energy storage and require increasingly fine control of their physical properties and composition. While composite nanoparticles have been widely synthesized and characterized, little work has systematically correlated the initial concentration of precursors and the final composition of flame synthesized composite nanoparticles. This relationship is explored in a diffusion flame aerosol reactor by coupling a scanning mobility particle sizer (SMPS) with an inductively coupled plasma optical emission spectrometer (ICP-OES). A framework for studying the relationship between the initial precursor concentrations of different elements and the final nanoparticle composition is explored. The size-resolved elemental composition was measured by directly injecting size-selected fractions of aggregated magnetite and silicon dioxide composite nanoparticles into the ICP-OES plasma. This work showed a correlation between precursor molar ratio and the measured elemental ratio in the mobility size range of 50 to 140 nm. Building on previous work studying size resolved elemental composition of engineered nanoparticles, the analysis is extended to flame synthesized composite nanoparticle aggregates in this work. Copyright © 2017 American Association for Aerosol Research
Der gelbe Lein (Linum flavum L.) auf der Südostalb
Creators: name: Müller, Karl
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study
Creators: name: Lingzhen Dai
name: Mehta, Amar
name: Mordukhovich, Irina
name: Just, Allan C.
name: Jincheng Shen
name: Lifang Hou
name: Koutrakis, Petros
name: Sparrow, David
name: Pantel S. Vokonas
name: Baccarelli, Andrea A.
name: Schwartz, Joel D.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Although there is growing evidence that exposure to ambient particulate matter is associated with global DNA methylation and gene-specific methylation, little is known regarding epigenome-wide changes in DNA methylation in relation to particles and, especially, particle components. Using the Illumina Infinium HumanMethylation450 BeadChip, we examined the relationship between one-year moving averages of PM2.5 species (Al, Ca, Cu, Fe, K, Na, Ni, S, Si, V, and Zn) and DNA methylation at 484,613 CpG probes in a longitudinal cohort that included 646 subjects. Bonferroni correction was applied to adjust for multiple comparisons. Bioinformatics analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment was also performed. We observed 20 Bonferroni significant (P-value < 9.4 × 10−9) CpGs for Fe, 8 for Ni, and 1 for V. Particularly, methylation at Schlafen Family Member 11 (SLFN11) cg10911913 was positively associated with measured levels of all three species. The SLFN11 gene codes for an interferon-induced protein that inhibits retroviruses and sensitizes cancer cells to DNA-damaging agents. Bioinformatics analysis suggests that gene targets may be relevant to pathways including cancers, signal transduction, and cell growth and death. Ours is the first study to examine the epigenome-wide association between ambient particles species and DNA methylation. We found that long-term exposures to specific components of ambient particle pollution, especially particles emitted during oil combustion, were associated with methylation changes in genes relevant to immune responses. Our findings provide insight into potential biological mechanisms on an epigenetic level.
Real-time Measurement of Size-Resolved Elemental Composition Ratio for Flame Synthesized Composite Nanoparticle Aggregates using a Tandem SMPS-ICP-OES
Creators: name: Reed, Nathan
name: Jiaxi Fang
name: Sanmathi Chavalmane
name: Pratim Biswas
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: Composite nanoparticles find application in catalysis, drug delivery, and energy storage and require increasingly fine control of their physical properties and composition. While composite nanoparticles have been widely synthesized and characterized, little work has systematically correlated the initial concentration of precursors and the final composition of flame synthesized composite nanoparticles. This relationship is explored in a diffusion flame aerosol reactor by coupling a scanning mobility particle sizer (SMPS) with an inductively coupled plasma optical emission spectrometer (ICP-OES). A framework for studying the relationship between the initial precursor concentrations of different elements and the final nanoparticle composition is explored. The size-resolved elemental composition was measured by directly injecting size-selected fractions of aggregated magnetite and silicon dioxide composite nanoparticles into the ICP-OES plasma. This work showed a correlation between precursor molar ratio and the measured elemental ratio in the mobility size range of 50 to 140 nm. Building on previous work studying size resolved elemental composition of engineered nanoparticles, the analysis is extended to flame synthesized composite nanoparticle aggregates in this work.
Topological transitions in two-dimensional Floquet superconductors
Creators: name: Wenk, Paul
name: Grifoni, Milena
name: Schliemann, John
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: QUANTUM; CONDUCTANCE; ELECTRON
subject: 530 Physik

description: We demonstrate the occurrence of a topological phase transition induced by an effective magnetic field in a two-dimensional electron gas with spin-orbit coupling and in proximity to an s-wave superconductor. The effective, perpendicular magnetic field is generated by an in plane, off-resonant ac-magnetic field or by circularly polarized light. The conditions for entering the topological phase do not rely on fine parameter tuning: For fixed frequency, one requires a minimal amplitude of the effective field which can be evaluated analytically. In this phase, chiral edge states generally emerge for a system in stripe geometry unless the Rashba and Dresselhaus coupling have the same magnitude. In this special case, for magnetic field driving the edge states become Majorana flat bands, due to the presence of a chiral symmetry; the light irradiated system is a trivial superconductor.
ACTing on perfectionism: a single case experimental design examining the effect of Acceptance and Commitment Therapy on multidimensional perfectionism
Creators: name: Hunt, Jenna
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: Perfectionism is a personality construct argued to be widespread with the potentialfor incapacitation (Pacht, 1984). It has been linked with a host of psychologicaldifficulties impacting on social and occupational problems as well as physical andmental health. Interest in multi-dimensional perfectionism is growing and the searchto uncover the domains within perfectionism which are adaptive, and should benurtured, or maladaptive, and requiring intervention, remains ongoing. Perfectionismis considered transdiagnostic and targeting this construct may lead to symptomreduction across a range of other difficulties (Howell, et al., 2016). CognitiveBehavioural Therapies (CBT) are the current focus of interventions for perfectionism.Research has indicated some success in managing perfectionistic traits through CBTtechniques, however, there are limitations to these studies.Acceptance and Commitment Therapy (ACT), a third wave CBT approach, focuseson altering the function of thought processes and changing the relationship withprivate events rather than trying to change the event itself (Guarna, 2009). Thisapproach claims to be transdiagnostic and therefore may be an appropriatealternative to traditional CBT techniques for perfectionism.A multiple single case design was employed to examine the effect of a guided selfhelp ACT intervention on perfectionism across five replications using self report andbehavioural tasks as outcome measures. The effect of specific ACT processes wasexamined.Results were inconsistent across participants but some replication of effect wasfound for improved psychological flexibility, perfectionism and distress. The findingsindicate that a guided self help ACT intervention could be an effective treatment forperfectionism, as decreased perfectionism and decreased self reported distresswere found following the intervention. Further research is warranted to examine theimpact of this intervention further.
Investigation of the Risk Factors Associated with Prediabetes in Normal-Weight Qatari Adults: A Cross-Sectional Study
Creators: name: Mohamed, Mohamed Abbas Fadl Alla
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 40
subject: Engineering

description: This study investigates the risk factors associated with prediabetes in normal weight Qatari adults. Prediabetes is the condition in which the blood has above normal amount of glucose present, as its not high enough to be Identified as diabetes. Research has shown the increased burden of prediabetes in Qatar to rise substantially in the future. Early detection can help in the management of prediabetes and prevention of diabetes. Through the use of binomial logistic model, the risk factors most associated with prediabetes were identified. Then we used the receiver operating characteristics (ROC) to build a responsive and accurate threshold between positive or negative test returns for prediabetes. The sample/population was obtained from Qatar Biobank which included demographic data of 6 thousand Qatari individuals aged between 18 and 86 years. The use of several machine learning model showed that, after adjusting the potential confounding factors such as age and sex, Triglyceride has been demonstrated to be positively correlated with prediabetes, and there was a special population dependence phenomenon. Among them, non-obese people (p<0.05). The effect value and 95% confidence interval and OR of prediabetes was 2.79 and (e0.78, e1.28), respectively. Based on a logistic regression analysis of the relationship between prediabetes and the risk factors present, we conclude that triglyceride is the main risk factor for prediabetes in normal-weight individuals and should not be taken lightly when performing medical tests on the aforementioned weight category.
Zur Verbreitung mehrerer Käferfamilien in Fließgewässern Nordwürttembergs
Creators: name: Buck, Harald
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
ACTing on perfectionism: a single case experimental design examining the effect of Acceptance and Commitment Therapy on multidimensional perfectionism
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C800 - Psychology

description: Perfectionism is a personality construct argued to be widespread with the potentialfor incapacitation (Pacht, 1984). It has been linked with a host of psychologicaldifficulties impacting on social and occupational problems as well as physical andmental health. Interest in multi-dimensional perfectionism is growing and the searchto uncover the domains within perfectionism which are adaptive, and should benurtured, or maladaptive, and requiring intervention, remains ongoing. Perfectionismis considered transdiagnostic and targeting this construct may lead to symptomreduction across a range of other difficulties (Howell, et al., 2016). CognitiveBehavioural Therapies (CBT) are the current focus of interventions for perfectionism.Research has indicated some success in managing perfectionistic traits through CBTtechniques, however, there are limitations to these studies.Acceptance and Commitment Therapy (ACT), a third wave CBT approach, focuseson altering the function of thought processes and changing the relationship withprivate events rather than trying to change the event itself (Guarna, 2009). Thisapproach claims to be transdiagnostic and therefore may be an appropriatealternative to traditional CBT techniques for perfectionism.A multiple single case design was employed to examine the effect of a guided selfhelp ACT intervention on perfectionism across five replications using self report andbehavioural tasks as outcome measures. The effect of specific ACT processes wasexamined.Results were inconsistent across participants but some replication of effect wasfound for improved psychological flexibility, perfectionism and distress. The findingsindicate that a guided self help ACT intervention could be an effective treatment forperfectionism, as decreased perfectionism and decreased self reported distresswere found following the intervention. Further research is warranted to examine theimpact of this intervention further.
Binding, Bending and G Jumping in the Minor Groove: Experimental and Theoretical Approaches
Creators: name: Rahimian, Maryam
Publisher: name: Georgia State University
Year: 2008

description: It has been shown that heterocyclic diamidines, a class of minor groove binders, are promising antimicrobial agents. These compounds bind none covalently to the minor groove of A/T rich regions of the kinetoplast DNA and kill the parasite. The mechanism of action of these compounds is not well understood, yet many hypotheses have been proposed. One of the methods that improve the specificity is cooperative binding. Since there are many binding sites available in k-DNA thus the cooperativity in adjacent binding sites is desirable. A library of compounds has been scanned and few of those compounds identified that are able to bind to two adjacent A/T binding sites separated by a single G. Many biophysical methods such as isothermal titration calorimetry, surface Plasmon resonance, circular dichroism and thermal melting have been used to explore the thermodynamic profiles and binding mode of these compounds. The pulsed field gradient NMR was used to investigate the structural changes to the DNA sequence upon binding of the minor groove binders and find a correlation between their biological difference and structural changes. The molecular dynamics was applied to look at the interaction of some of the heterocyclic diamidines to the DNA with more details and predict the unknown structures.
ZrCl4-mediated synthesis of 1,2,3-triazoles from vinyl nitrates and their biological evaluation
Creators: name: Gattu Sridhar
name: Mudavath Somnath
name: Gangavaram V. M. Sharma
name: Thodupunuri Prashanth
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: A ZrCl4-mediated simple method for the conversion of vinyl nitrates to 1,2,3-triazoles in excellent yields is developed. The obtained new triazoles were evaluated for their antimicrobial activity.
Integration of Extracellular and Intracellular Calcium Signals: Roles of Calcium-Sensing Receptor (CASR), Calmodulin and Stromal Interaction Molecule 1 (STIM1)
Creators: name: Huang, Yun
Publisher: name: Georgia State University
Year: 2008

description: Ca2+, both as a first and a second messenger, is closely involved in the modulation and regulation of numerous important cellular events, such as cell proliferation, differentiation and cell death. Fine-tuned Ca2+ signaling is achieved by its reversible or irreversible binding to a repertoire of Ca2+ signaling molecules. Among them, the extracellular calcium sensing receptor (CaSR) senses Ca2+ concentration ([Ca2+]o) in the milieu outside of cells where Ca2+ serves as a first messenger. An array of naturally-occurring mutations in CaSR has been found in patients with inherited disorders of Ca2+ homeostasis, leading to abnormal intracellular responses toward [Ca2+]o.

In the present study, we have computationally predicted and experimentally characterized the metal-binding properties of five Ca2+-binding sites within CaSR and the accompanying metal--induced conformational changes by using two complementary methods-the grafting approach and the subdomain approach. Based on our results, a model has been proposed to explain the distinct CaSR-mediated responses toward abnormally ­øhigh­ñ or ­ølow­ñ extracellular Ca2+ levels. In addition, we predicted and verified the interaction between CaSR with the most ubiquitously expressed four EF-hand-containing intracellular Ca2+ sensor protein, calmodulin (CaM). Our results demonstrate that the C-terminal CaM-binding domain of the CaSR is essential for proper intracellular Ca2+ response to external signals.

Furthermore, we have applied the grafting approach to study the metal-binding properties and oligomeric state of the single EF-hand containing protein, STIM1. Our studies confirmed that the single EF-hand motif in STIM1, which resides in an equilibratium between its monomeric and dimeric forms, was capable of binding Ca2+ with a dissociation constant comparable to the ER Ca2+ concentration, suggesting it could function as a ER Ca2+ sensor responsible for sensing the Ca2+ filling state of ER.
Differential DNA methylation and PM2.5 species in a 450 K epigenome-wide association study
Creators: name: Lingzhen Dai
name: Mehta, Amar
name: Mordukhovich, Irina
name: Just, Allan C.
name: Jincheng Shen
name: Lifang Hou
name: Koutrakis, Petros
name: Sparrow, David
name: Pantel S. Vokonas
name: Baccarelli, Andrea A.
name: Schwartz, Joel D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Although there is growing evidence that exposure to ambient particulate matter is associated with global DNA methylation and gene-specific methylation, little is known regarding epigenome-wide changes in DNA methylation in relation to particles and, especially, particle components. Using the Illumina Infinium HumanMethylation450 BeadChip, we examined the relationship between one-year moving averages of PM2.5 species (Al, Ca, Cu, Fe, K, Na, Ni, S, Si, V, and Zn) and DNA methylation at 484,613 CpG probes in a longitudinal cohort that included 646 subjects. Bonferroni correction was applied to adjust for multiple comparisons. Bioinformatics analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment was also performed. We observed 20 Bonferroni significant (P-value < 9.4× 10−9) CpGs for Fe, 8 for Ni, and 1 for V. Particularly, methylation at Schlafen Family Member 11 (SLFN11) cg10911913 was positively associated with measured levels of all 3 species. The SLFN11 gene codes for an interferon-induced protein that inhibits retroviruses and sensitizes cancer cells to DNA-damaging agents. Bioinformatics analysis suggests that gene targets may be relevant to pathways including cancers, signal transduction, and cell growth and death. Ours is the first study to examine the epigenome-wide association between ambient particles species and DNA methylation. We found that long-term exposures to specific components of ambient particle pollution, especially particles emitted during oil combustion, were associated with methylation changes in genes relevant to immune responses. Our findings provide insight into potential biologic mechanisms on an epigenetic level.
title: AI3SD Semantics & knowledge learning for chemical design workshop report 2019
Creators: name: Kanza, Samantha
Publisher: name: University of Southampton
Year: 2019
Subjects: subject: AI3SD, Workshop Report, Semantics, Semantic Web, Chemical Design, Ontologies, RDF, Linked Data, Inferences, Learning

description: This event was run by AI3SD and was designed to explore the different aspects of using semantic web technologies in the chemical space, and to promote discussions about why these technologies are so important and the different ways in which they can be used. The event was a full day, hosted at the Solent Conference Centre in Southampton. The programme was made up of a number of presentations, starting with the importance of provenance of data and a history of the semantic web over the last 20 years with some details of where we are now. The event then progressed to some more specific talks about using semantic web technologies in the chemical domain, to make predictions and to model different aspects of chemistry in ontologies. These presentations were all run consecutively so it was possible to attend each talk, and the final order of the day was an expert panel made up of the speakers. There was plenty of time for networking, as there was both a lunch and drinks session included as part of the day.
Zur rotatorienfauna des Monrepos-Teiches bei Ludwigsburg
Creators: name: Klement, Volker
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
Development of Boronic Acid-Based Chemosensors
Creators: name: Jin, Shan
Publisher: name: Georgia State University
Year: 2009

description: It is well known that boronic acids can bind with diols and can be further applied as chemosensors for biomolecules such as carbohydrates and dopamine. Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents.