cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Return to Everyday Activity in the Community and Home: a feasibility study for a lifestyle intervention to sit less, move more, and be strong
Creators: name: Ashe, Maureen C
name: Edwards, Nicola Y
name: Taylor, Amanda
name: Burnett, Laura
name: Giangregorio, Lora
name: Milne, Kate
name: Clemson, Lindy
name: Fleig, Lena
Publisher: name: BioMed Central
Year: 2019

description: Background: Many interventions designed to meet physical activity guideline recommendations focus on a single component (e.g., walking), to the detriment of other elements of a healthy lifestyle, such as reducing prolonged sitting and doing balance and strength exercises (i.e., bundled multiple behaviors). Adopting these multiple health behaviors within daily life routines may facilitate uptake and support longer-term behavior change. We tested feasibility for a three-part lifestyle intervention to support older women to sit less, move more, and complete balance and strength exercises. Methods: We used a convergent parallel mixed-methods, single-arm study design to test feasibility for a 6-week lifestyle intervention: Return to Everyday Activities in the Community and Home (REACH). We collected information at baseline, 3 and 6 weeks (final), and 6 months (follow-up) using questionnaires, semi-structured interviews, and performance-based measures. We describe three key elements: (1) implementation factors such as recruitment, retention, program delivery, and adherence; (2) participants’ acceptability and experience with the program; and (3) health outcomes, including participants’ global mobility, activity, and perceptions of their physical activity identity, and habit strength for (i) physical activity, (ii) breaking up sitting time, and (iii) balance and strength exercises. Results: We were able to recruit enough participants in the allotted time to conduct one cycle of the REACH group-based program. There were 10 community-dwelling women, median (p25, p75) age 61 (57.5, 71) years, who completed the study. The program was feasible to deliver, with high attendance (mean 5/6 sessions) and positive overall ratings (8/10). Participants rated session content and length high, and educational materials as highly acceptable and understandable. Although participants were active walkers at baseline, few were breaking up prolonged sitting or participating in any balance and strength exercises. At final and follow-up assessments, participants reported developing habits for all three health behaviors, without diminishing physical activity. Conclusion: These results show acceptability of the program and its materials, and feasibility for bundling multiple health behaviors within the REACH program. It also provides confirmation to advance to testing feasibility of this three-part lifestyle intervention with older, less active, adults. Trial registration ClinicalTrials.gov Identifier, NCT02786394 ; May 18, 2016.
Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices
Creators: name: Ihle, Michaela A.
name: Hampp, Stephanie
name: Schröder, Insa Sigrid
name: Blattner, Christine
name: Deniz, Miriam
name: D'Amia, Giovanna
name: Gottifredi, Vanesa
name: Wiesmüller, Lisa
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Genome integrity
subject: Repair and replication
subject: DDC 570 / Life sciences
subject: DNA replication
subject: Replikation

description: Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated cells synthesize DNA faster and accumulate DNA damage. Notably, both replication phenotypes depend on p53 and polymerase iota (POL ). By exploring protein interactions and newly synthesized DNA, we show that SCs promote complex formation of p53 and POL at replication sites. Intriguingly, in SCs the translocase ZRANB3 is recruited to POL and required for slow-down of DNA replication. The known role of ZRANB3 in fork reversal suggests that the p53–POL complex mediates slow but safe bypass of replication barriers in SCs. In differentiated cells, POL localizes more transiently to sites ofDNA synthesis and no longer interactswith p53 facilitating fast POL -dependent DNA replication. In this alternative scenario, POL associates with the p53 target p21, which antagonizes PCNA polyubiquitination and, thereby potentially disfavors the recruitment of translocases. Altogether, we provide evidence for diametrically opposed DNA replication phenotypes in SCs and their differentiated counterparts putting DNA replication-based strategies in the spotlight for the creation of therapeutic opportunities targeting SCs.
Dangerous Young Men: Themes of Female Sexuality and Masculinity in Paranormal Romance Novels for Young Adults
Creators: name: Russell, Shannon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Masculinity
Sexuality
Young Adult Romance Novels
Patriarchy
Female Sexuality

description: Patterns of masculine and feminine portrayals can be found everywhere, yet one place sociologists tend not to look is in novels. Young adult novels have generated 27 million dollars in e-books alone in 2011, with paranormal romances and dystopian genres making up the majority of the sales (Scott, 2013). Understanding these novels is sociologically important because they are reaching wider audiences with their adaptation into Hollywood blockbusters. While the novels demonstrate stronger characteristics given to women, the messages about the ideal male in the novel often reflects one who is putting the female in danger. A content analysis of ten popular paranormal young adult novels demonstrates patterns of the construction of gender. Drawing on Radway’s (1984) analysis of romance novels and Connell’s, (2005) and hook’s (2004) theories of masculinities, this paper explores the messages in paranormal fiction geared to a mainly young adult female reading audience. My preliminary findings demonstrate thus far that these books reflect unhealthy ideas about relationships, violence, the body, and sexuality. The novels portray masculine bodies as hard, dangerous, and seductive. They also share a storyline consisting of the fear of getting killed by someone they are in love with.
Supplementary document for Quantum-randomized polarization of laser pulses derived from zero-point motion of diamond - 5004267.pdf
Creators: name: Little, Douglas
name: Kitzler, Ondrej
name: Abedi, Seyed
name: Alias, Akael
name: Gilchrist, Alexei
name: Mildren, Richard
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Derivation of Stokes fields and output of NIST 800-90B statistical tests
Re-Invigorating HIBAR Research for the 21st Century : Enhancing Fundamental Research Excellence in Service to Society
Creators: name: Whitehead, Lorne
name: Slovic, Scott, 1960-
name: Nelson, Janet E.
Publisher: name: The University of British Columbia
Year: 2019

description: More than ever, society needs research breakthroughs to address major problems. Universities have a key role to play in discovering the required new knowledge and guiding its application. However, since World War II, universities have been encouraged to focus mainly on curiositybased research, with corporations carrying out practical work. This division worked well in the last half of the 20th century, when there was considerable funding for long-term research in the laboratories of major corporations. Today, however, those firms face greater competition, and the resultant financial constraints have foreshortened their research time-horizons. Universities are poised to compensate by re-emphasizing long-term, application-oriented research, but great care must be taken to strengthen fundamental research as well. These objectives can be achieved simultaneously by bolstering a time-honored class of research projects labelled “Highly Integrative Basic And Responsive” (HIBAR), which combine fundamental and applied approaches through partnerships with practical experts. This will help replicate, within universities, the breakthrough-generation capacity that once flourished in major corporate laboratories. Toward this end, a network of universities called the HIBAR Research Alliance (HRA) has recently formed to strengthen HIBAR research, by helping universities to encourage it (while also improving equity, diversity, inclusion, and academic freedom), and by helping researchers to carry out HIBAR projects (while also advancing their careers). The HRA aims to increase the rate of HIBAR projects in universities, from about one project in 20 today, to one in 5 by 2030, while strengthening all types of research excellence.
Rahmendaten für den Projektionsbericht 2023
Creators: name: Mendelevitch, Roman
name: Repenning, Julia
name: Matthes, Felix Christian
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Monitoring
subject: Projektionsbericht
subject: Rahmendaten
subject: Bundes-Klimaschutzgesetz
subject: Treibhausgasprojektionen
subject: Governance-Verordnung
subject: Klima | Energie

description: Die Annahmen zu Rahmendaten für die Modellierung des Projektionsberichtes werden standardmäßig vor dem Modellierungsstart von den Forschungsnehmenden in Zusammenarbeit mit dem âĄ UBAâĄ erstellt und mit den Ressorts abgestimmt. Erstmals werden diese frühzeitig zum Modellierungsstart der Öffentlichkeit zur Verfügung gestellt. Das Vorhaben Politikszenarien XI dient der Erstellung der Projektionen für den Projektionsbericht 2023 laut KSG §10(2) und der EU Governance-Verordnung. Quelle: www.umweltbundesamt.de
description: Die Annahmen zu Rahmendaten für die Modellierung des Projektionsberichtes werden standardmäßig vor dem Modellierungsstart von den Forschungsnehmenden in Zusammenarbeit mit dem ⁠UBA⁠ erstellt und mit den Ressorts abgestimmt. Erstmals werden diese frühzeitig zum Modellierungsstart der Öffentlichkeit zur Verfügung gestellt.Das Vorhaben Politikszenarien XI dient der Erstellung der Projektionen für den Projektionsbericht 2023 laut KSG §10(2) und der EU Governance-Verordnung.
Performance of ceiling diaphragms in steel-framed domestic structures subjected to wind loading
Creators: name: Saifullah, Ismail
Publisher: name: Swinburne
Year: 2024

description: The aim of this research is to develop a rational holistic model for bracing of steel-framed houses. The focus of this research is on houses built with cold-formed steel frames, however, the findings of this work potentially extend to other framing materials. More reliable and rational design methods will provide the level of safety and security the community under extreme events like as cyclone and earthquake. The development of rational design methods would allow Australian designers and manufacturers to develop optimised system rather than relying on extrapolation of historical empirical data. This would foster innovation in such an important sector of industry in both Australia and internationally.
Cargo and Functional Profile of Saliva-Derived Exosomes Reveal Biomarkers Specific for Head and Neck Cancer
Creators: name: Hofmann, Linda
name: Medyany, Valentin
name: Ezić, Jasmin
name: Lotfi, Ramin
name: Niesler, Beate
name: Röth, Ralph
name: Engelhardt, Daphne
name: Laban, Simon
name: Schuler, Patrick J.
name: Hoffmann, Thomas K.
name: Brunner, Cornelia
name: Jackson, Edwin K.
name: Theodoraki, Marie-Nicole
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Head and neck squamous cell carcinoma (HNSCC)
subject: miRNA
subject: DDC 610 / Medicine & health
subject: Squamous cell carcinoma of head and neck
subject: Exosomes
subject: MicroRNAs
subject: Liquid biopsy
subject: Saliva
subject: Plattenepithelcarcinom
subject: Hals-Nasen-Ohren-Tumor
subject: miRNS
subject: Exosom

description: Background Exosomes contribute to immunosuppression in head and neck squamous cell carcinoma (HNSCC), a tumor entity which lacks specific tumor biomarkers. Plasma-derived exosomes from HNSCC patients correlate with clinical parameters and have potential as liquid biopsy. Here, we investigate the cargo and functional profile of saliva-derived exosomes from HNSCC patients and their potential as non-invasive biomarkers for disease detection and immunomodulation. Methods Exosomes were isolated from saliva of HNSCC patients (n = 21) and healthy donors (HD, n = 12) by differential ultracentrifugation. Surface values of immune checkpoints and tumor associated antigens on saliva-derived exosomes were analyzed by bead-based flow cytometry using CD63 capture. Upon co-incubation with saliva-derived exosomes, activity and proliferation of T cells were assessed by flow cytometry (CD69 expression, CFSE assay). Adenosine levels were measured by mass spectrometry after incubation of saliva-derived exosomes with exogenous ATP. miRNA profiling of saliva-derived exosomes was performed using the nCounter® SPRINT system. Results Saliva-derived, CD63-captured exosomes from HNSCC patients carried high amounts of CD44v3, PDL1 and CD39. Compared to plasma, saliva was rich in tumor-derived, CD44v3+ exosomes and poor in hematopoietic cell-derived, CD45+ exosomes. CD8+ T cell activity was attenuated by saliva-derived exosomes from HNSCC patients, while proliferation of CD4+ T cells was not affected. Further, saliva-derived exosomes produced high levels of immunosuppressive adenosine. 62 HD- and 31 HNSCC-exclusive miRNAs were identified. Samples were grouped in “Healthy” and “Cancer” based on their saliva-derived exosomal miRNA profile, which was further found to be involved in RAS/MAPK, NF-κB complex, Smad2/3, and IFN-α signaling. Conclusions Saliva-derived exosomes from HNSCC patients were enriched in tumor-derived exosomes whose cargo and functional profile reflected an immunosuppressive TME. Surface values of CD44v3, PDL1 and CD39 on CD63-captured exosomes, adenosine production and the miRNA cargo of saliva-derived exosomes emerged as discriminators of disease and emphasized their potential as liquid biomarkers specific for HNSCC.
Supplementary document for Comparative study of autofluorescence in flat and tapered optical fibers towards application in depthresolved fluorescence lifetime photometry in brain tissue - 5004765.pdf
Creators: name: Bianco, Marco
name: Balena, Antonio
name: Pisanello, Marco
name: Pisano, Filippo
name: Sileo, Leonardo
name: Spagnolo, Barbara
name: Montinaro, Cinzia
name: Sabatini, Bernardo
name: De Vittorio, Massimo
name: Pisanello, Ferruccio
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Figures
Le concept de soi : voie d’épanouissement ou d’emprisonnement du capital social?
Creators: name: Richer, Céline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: concept de soi
capital social
vérification de soi
schéma
soi
réseau social

description: La présente étude vise à mieux comprendre quelle dynamique corrélationnelle s’inscrit entre le concept de soi d’un individu et son capital social. La théorie de la vérification de soi (Swann, 1987) sous-tend que les individus ont tendance à s’entourer de gens qui confirment leur vision d’eux même, dans le but de pouvoir prédire et contrôler leur environnement. On peut alors se demander si la personne dont le soi est tapissé de représentations négatives a précisément la capacité de se construire un réseau social qui constituera véritablement un « capital » relationnel pour elle. Un design méthodologique corrélationnel a été utilisé afin d’évaluer les liens de concomitance entre les indicateurs des construits « concept de soi » et « capital social. » Les résultats d’analyses statistiques corrélationnelles entre les indicateurs confirment, en grande partie, l’hypothèse de départ, à savoir que plus une personne nourrit un concept de soi sain, plus elle génère un capital social riche. Les implications pratiques et théoriques sont discutées.
A transgenic plant system for the heterologous expression of bioproducts in soybean seed coats
Creators: name: Schnell, Jaimie A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.
subject: Agriculture, Plant Culture.

description: A transgenic system for the heterologous expression of bioproducts in soybean (Glycine max (L.) Merrill) seed coats was developed. Expression was driven by the region upstream of the high expressing, seed coat-specific Ep gene, which encodes soybean peroxidase (SBP). Genes were modified to include sequences encoding the N- and C-terminal propeptides from SBP, which were predicted to target proteins to the vacuole. To investigate the influence of targeting on foreign protein accumulation, a model system was developed. Arabidopsis thaliana (L.) Heynh. plants were transformed with genes encoding SBP-green fluorescent protein (GFP) fusions, targeted to the cytoplasm, apoplast, endoplasmic reticulum (ER), or vacuole with combinations of the SBP N- and C-terminal propeptides and an ER retention signal. The location of the targeted fusion proteins and the function of the SBP N- and C-terminal propeptides were confirmed. Average specific activity of all three of the targeted fusion proteins was significantly greater than the average specific activity of the non-targeted, cytoplasmic fusion protein. Immunoblotting revealed that the GFP portion of the fusion protein was being partially degraded, and that degradation was more severe during targeting to the vacuole and apoplast than the ER. These results suggest that targeting proteins to any of the three compartments investigated can significantly improve protein accumulation but that maximum stability may be found in the ER. To compare the ability of soybean seed coats to express foreign proteins at levels comparable to the Ep gene, the Ep cDNA was heterologously expressed in a soybean cultivar that contains a deletion in the Ep gene, designated epep. Transgenic Ep plants produced SBP but activity levels were lower than those measured in the EpEp cultivar Harosoy 63. This suggests that elements necessary for the high expression levels of the Ep locus were omitted in the construct. To investigate the applicability of metabolically engineering soybean seed coats to divert metabolism towards the production of novel biochemicals, we introduced the polyhydroxybutyric acid (PHB) biosynthetic enzymes into soybean. PHB was produced at levels up to an average of 0.13% of seed coat DW. Although the levels of PHB are low, these results demonstrate that it is possible to metabolically engineer soybean seed coats.
Identification and detailed characterization of a novel origin of DNA replication in the transcriptional promoter of the human DBF4 gene
Creators: name: Romero, Julia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: Origins of DNA replication (oris) are the genomic sites where DNA synthesis starts to duplicate a cell's genome. Although prokaryotic and yeast oris have been characterized in detail, the nature of mammalian oris is still ill-defined. In fact, of ∼30,000 oris estimated to exist in mammalian genomes, only the one localized at the human lamin B2 locus has been mapped with nucleotide resolution. This thesis describes the identification of a novel human on located around the transcriptional promoter of the DBF4 gene. Using a modified version of the replication initiation point (RIP) mapping technique, precise leading strand initiation sites have been determined at this new ori. Additionally, chromatin immunoprecipitation (ChIP) assays have been employed to study the interaction of replication and transcription proteins within the ori region. The data presented here demonstrate that, at the DBF4 ori, DNA replication can initiate from multiple potential start-sites which are distributed within two replication initiation zones. These zones are separated by ∼400 bp and are localized near binding sites for the origin recognition complex (ORC) and the Sp1 transcription factor. Strikingly, initiation of DNA synthesis from the two zones occurs sequentially and not simultaneously: replication starts first from initiation zone I and proceeds in the direction of DBF4 transcription, followed by activation of zone II and DNA synthesis from the complementary strand. This replication pattern, termed asymmetric bidirectional replication (ABR), is reminiscent of initiation at oriC in Escherichia coli but greatly differs from what is observed at the lamin B2 ori, where a single ORC-binding site and unique replication start-points have been reported. Overall, the data suggest, for the first time, that eukaryotic replication initiation can take place through either the traditional origin of bidirectional replication (OBR) model, such as is the case in budding yeast and at the human lamin B2 ori, or through the asymmetric ABR model described here for the DBF4 ori.
Erarbeitung von Vorschlägen für ein repräsentatives Messnetz zur Überwachung der Wirkungen bodennahen Ozons in Umsetzung der Richtlinie (EU) 2016/2284, Artikel 9 und Anhang V
Creators: name: Schad, Tobias
name: Sanders, Tanja
name: Werner, Willy
Publisher: name: Deutschland. Umweltbundesamt
Year: 2018
Subjects: subject: Troposphärisches Ozon
subject: Ozonmonitoring
subject: Ozonauswirkungen
subject: Bodennahes Ozon
subject: Ozonwirkung auf Ökosysteme
subject: EU-Richtlinie 2016/2284
subject: Überwachungsstationen Ozon
subject: Luft

description: Die Richtlinie (EU) 2016/2284 schreibt in Artikel 9 die Überwachung der Auswirkungen bodennahen Ozons auf Ökosysteme vor. Die Mitgliedsstaaten sollen ab 2019 regelmäßig im Abstand von vier Jahren Daten zu bestimmten Indikatoren für die Ozonwirkung an die Europäische Umweltagentur berichten. In dem Gutachten wurde geprüft, ob die in Deutschland bestehenden Überwachungsstationen für Ozon die Anforderungen der EU-Richtlinie erfüllen und welche Verbesserungen gegebenenfalls notwendig wären.
Exploring the militarization of Palestinian society: Cynthia Enloe's framework of militarization and Palestinian children
Creators: name: Solomon, Inbal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Anthropology, Cultural.
subject: Sociology, Criminology and Penology.

description: Recent literature has assessed the particular circumstances of Palestinian children, generally attempting to conceptualize them as either politically-charged and violent, or as marginalized citizens, victimized by dominating Israeli practices. This research attempts to broaden these conceptualizations, by exploring the relevance of Cynthia Enloe's (2000) concept of militarized maneuvering. Enloe postulates inter alia that militarization is a process which involves the obfuscation of the military's problematic nature for civil society and the almost taking for granted of military's (often violent) strategies; it occurs as societal conditions, discourses, definitions, attitudes, thoughts and expectations are produced (and re-produced). This thesis has employed an inductive qualitative study to explore the means through which Palestinian children may progress through the process of militarization, employing a coding approach to data analysis. It has studied Identity Card (1964), considered to be the "Palestinian national poem", written by "the Palestinian national poet", Mahmoud Darweish and has drawn reference to secondary literature detailing the impacts of the newly-constructed Israeli Separation Barrier on Palestinian populations. Palestinian populations may undergo the process of militarization through some of the available nationalist poetry, which offers discourses commemorating the historical connection of Palestinians with the land lost in 1948, and emphasizes the need for steadfastness, nationalism and resistance. This thesis has found that the barrier is a force which both directly and indirectly militarizes children's social conditions, exemplifying past (perceived) victimization, obstructing daily life, and oppressing Palestinians' future nation. It may also be interpreted to reinforce the desire for resistance, and therefore potentially garner support for militarized retaliatory acts against Israelis. This approach has illuminated an important and unexpected finding; the two seemingly disjoined realms of Palestinian society are undergirded by the abstract themes of collective memory and nationalism, suggesting that these are significant elements to the study of the militarization of Palestinian society, thereby offering a means to broaden the aforementioned traditional conceptualizations of Palestinian children.
Quality of service driven packet scheduling disciplines for real-time applications: looking beyond fairness
Creators: name: Hayes, David A.
name: Rumsewicz, Michael
name: Andrew, Lachlan L. H.
Publisher: name: Swinburne
Year: 2024

description: In this paper we focus on real-time scheduling of `soft' real-time data services such as multimedia data, MPEG video streaming and IP telephony, which can tolerate a small degree of loss or delay. We argue that network operators and service providers should be able to select from a range of Quality of Service objectives, including maximizing the number of customers receiving good service. Further, we argue that scheduling disciplines such as fair queueing are unable to achieve such goals and hence there is a need for alternative approaches. We propose a new scheduling scheme, which we call the Dual Queue discipline. We show that the Dual Queue has the flexibility to satisfy a variety of QoS objectives, ranging from existing notions of fairness through to maximizing the number of customers receiving good service. In addition, even the simplest Dual Queue implementation outperforms Fair Queueing, is scalable in the number of active sessions, and can be made fair, if desired, over moderate to long time scales.
Supplementary document for Comparative study of autofluorescence in flat and tapered optical fibers towards application in depthresolved fluorescence lifetime photometry in brain tissue - 5004765.pdf
Creators: name: Bianco, Marco
name: Balena, Antonio
name: Pisanello, Marco
name: Pisano, Filippo
name: Sileo, Leonardo
name: Spagnolo, Barbara
name: Montinaro, Cinzia
name: Sabatini, Bernardo
name: De Vittorio, Massimo
name: Pisanello, Ferruccio
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplementary Figures
ORCID Ambassador Program.pdf
Creators: name: ORCID
Publisher: name: ORCID
Year: 2020
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: From 2013-2017, ORCID outreach activities were supported by a diverse cadre of energetic institutional and individual Ambassadors who encouraged the adoption of ORCID identifiers locally and globally. From 2018, with a much larger network of supporters, staff, and members, we have ended our Ambassador program. Learn more about where we are now and those involved in the ORCID Ambassador program.
Alteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line
Creators: name: Sohn, Juhae
name: Kim, Sujin
name: Koschorreck, Jan
name: Kho, Younglim
name: Choi, Kyungho
Publisher: name: My University
Year: 2016
Subjects: Fisch

description: Low molecular weight phthalates, such as diethyl phthalate (DEP), benzyl butyl phthalate (BBzP), or diisobutyl phthalate (DiBP), are suspected to disrupt endocrine system. However, their adverse effects on sex steroid hormones and underlying mechanisms are not well-documented. The aim of this study is to investigate the effects of major low molecular weight phthalates (LMWPs), i.e., DEP, BBzP, and DiBP, and their hydrolytic metabolites, on sex steroid hormone system, employing male zebrafish and/or a human adrenocortical carcinoma (H295R) cell. In male zebrafish, 14-day exposure to DEP, BBzP, or DiBP significantly decreased testosterone (T) concentrations. All test compounds significantly up-regulated cyp19agene expression, and down-regulated starand 3âhsd genes in the male fish. In H295R cell, all test compounds except monoisobutyl phthalate (MiBP) reduced T concentrations and increased E2/T ratio. Gene expression changes in H295R cell, e.g., significant down-regulation of StARgene and up-regulation of CYP19A gene, supported depressed synthesis of sex hormones in the adrenal cell. Our results show that not only DEP, BBzP, and DiBP, but also their hydrolytic metabolites disrupt sex hormone balances through modulating key steroidogenic genes in the human adrenal cells and in zebrafish.Quelle: http://www.sciencedirect.com/
Suppression of amplitude modulation of pulses generated from a subharmonically mode-locked semiconductor laser
Creators: name: Bao, H. C.
name: Liu, H. F.
name: Wen, Y. J.
name: Nirmalathas, A.
Publisher: name: Swinburne
Year: 2024

description: A feedforward modulation technique is used to suppress amplitude modulation associated with 40-GHz pulses generated from a subharmonically mode-locked semiconductor laser. It is shown that the amplitude modulation can be suppressed by as much as 20 dB. The improvement of amplitude modulation is shown for different subharmonic numbers.
How the ghosts of the nineteenth century still haunt education
Creators: name: Scott, Catherine
Publisher: name: Swinburne
Year: 2024

description: Research evidence has demonstrated that pedagogical techniques variously known as discovery learning, problem-based learning and constructivism are less effective than explicit instruction, especially when applied to the teaching of novice learners. Nonetheless these ineffective techniques have many devotees and re-enter the educational arena 're-badged' after each empirical revelation of their deficiencies. This article argues that constructivism and its pedagogical relatives are continually 'rediscovered' because they accord with deeply held beliefs about the nature of human beings. The origins of these ideas are traced to the writings of Rousseau and the Progressivist thinkers of the nineteenth century and the ways in which the misreading of theorists, such as Piaget, provide 'scientific support' for these is explored.
An 'Islamised Australian way of life': developing an Islamic social capital framework
Creators: name: Tolsma, Lauren
Publisher: name: Swinburne
Year: 2024

description: This paper discusses some preliminary findings of a larger ethnographic study which explores the role of Islamic faith in the creation and maintenance of social capital for first and second generation Muslim-Australian migrants. The paper reviews the literature on social capital before introducing the concept of 'Islamic social capital'. This will be followed by an overview of the methodology and study sample. Finally I present data that demonstrate how the participants' subjective understanding of the Islamic faith assists them in the development of social capital resources. The data presented in this paper shows that the participants actively contribute towards building 'Islamic social capital' through the pursuit of religious education outside of their local mosques. The data further suggest that the participants' understanding of Islamic values encouraged them to participate in non-Muslim social networks. These values focus on the importance of 'neighbourliness', inclusively, equality, fairness and social justice. This participation in non-Muslim social networks is further supported by what the participants understand to be an overlap between Islamic values and 'normal' Australian values.
title: "Vergleichende Analyse von Siedlungsrestabfällen aus repräsentativen Regionen in Deutschland zur Bestimmung des Anteils an Problemstoffen und verwertbaren Materialien"
title: "Vergleichende Analyse von Siedlungsrestabfällen aus repräsentativen Regionen in Deutschland zur Bestimmung des Anteils an Problemstoffen und verwertbaren Materialien"
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Restabfall
subject: Haushaltsabfall
subject: Restmüll
subject: Hausmüll
subject: Abfall | Ressourcen

description: Im Projekt "Vergleichende Analyse von Siedlungsrestabfällen aus repräsentativen Regionen in Deutschland zur Bestimmung des Anteils an Problemstoffen und verwertbaren Materialien" (Forschungskennzahl 3717 35 344 0) wurden die Menge und Zusammensetzung des Restmülls aus privaten Haushalten in Deutschland bestimmt. Im Fokus der Untersuchungen stand die detaillierte Bestimmung der noch im Hausmüll (wird hier synonym verwendet für Restmüll) enthaltenen Mengen an Wert- und Problemstoffen sowie die Untersuchung möglicher Abhängigkeiten von strukturellen und abfallwirtschaftlichen Rahmenbedingungen. Quelle: https://www.umweltbundesamt.de
description: Im Projekt „Vergleichende Analyse von Siedlungsrestabfällen aus repräsentativen Regionen in Deutschland zur Bestimmung des Anteils an Problemstoffen und verwertbaren Materialien“ (Forschungskennzahl 3717 35 344 0) wurden die Menge und Zusammensetzung des Restmülls aus privaten Haushalten in Deutschland bestimmt. Im Fokus der Untersuchungen stand die detaillierte Bestimmung der noch im Hausmüll (wird hier synonym verwendet für Restmüll) enthaltenen Mengen an Wert- und Problemstoffen sowie die Untersuchung möglicher Abhängigkeiten von strukturellen und abfallwirtschaftlichen Rahmenbedingungen.
Neural correlates of emotion regulation in the ventral prefrontal cortex and the encoding of subjective value and economic utility
Creators: name: Viviani, Roberto
Publisher: name: Universität Ulm
Year: 2014
Subjects: subject: Orbitofrontal cortex
subject: Ventromedial prefrontal cortex
subject: Subjective value
subject: Utility
subject: DDC 610 / Medicine & health
subject: Neuroeconomics
subject: Emotional regulation
subject: Prefrontal cortex
subject: Emotionsregulation
subject: Präfrontaler Cortex
subject: Nutzen
subject: Neuroökonomik

description: In many studies of the interaction between cognitive control and emotion, the orbitofrontal cortex/ventromedial prefrontal cortex (mOFC/vmPFC) has been associated with an inhibitory function on limbic areas activated by emotionally arousing stimuli, such as the amygdala. This has led to the hypothesis of an inhibitory or regulatory role of mOFC/vmPFC. In studies of cognition and executive function, however, this area is deactivated by focused effort, raising the issue of the nature of the putative regulatory process associated with mOFC/vmPFC. This issue is here revisited in light of findings in the neuroeconomics field demonstrating the importance of mOFC/vmPFC to encoding the subjective value of stimuli or their economic utility. Many studies show that mOFC/vmPFC activity may affect response by activating personal preferences, instead of resorting to effortful control mechanisms typically associated with emotion regulation. Based on these findings, I argue that a simple automatic/controlled dichotomy is insufficient to describe the data on emotion and control of response adequately. Instead, I argue that the notion of subjective value from neuroeconomics studies and the notion of attentional orienting may play key roles in integrating emotion and cognition. mOFC/vmPFC may work together with the inferior parietal lobe, the cortical region associated with attentional orienting, to convey information about motivational priorities and facilitate processing of inputs that are behaviorally relevant. I also suggest that the dominant mode of function of this ventral network may be a distinct type of process with intermediate properties between the automatic and the controlled, and which may co-operate with effortful control processes in order to steer response.
Social make-over for the corporate bottom line
Creators: name: Liffman, Michael
Publisher: name: Swinburne
Year: 2024

description: Private wealth - its sources, scale, distribution, and the uses to which it is put – is a fundamental driver of the ways in which our society functions. Recent years have seen enormous growth in wealth in many parts of the world, and – notwithstanding the global financial crisis – a growing awareness of how private wealth might be more equitably shared and more effectively used socially. This is being expressed in the wishes of more businesses to return something to communities in which they have prospered and on whose goodwill and health they depend. Combined with a trend for government to reduce its community resourcing and a realisation that neither the market nor the state can relieve us of all challenges and problems, more people are looking to the corporate sector to support and create community partnerships. Similarly, business is responding to needs and opportunities that make corporate philanthropy a worthwhile investment.
Supplementary document for Femtosecond Laser Induced In-Situ Crystallization of Tb-Based Luminescent Metal Organic Framework - 5005229.pdf
Creators: name: liu, yanan
name: chai, nianyao
name: wang, xuewen
name: Luo, Zhijun
name: zhao, junjie
name: Xie, Changsheng
name: Mai, Liqiang
name: Gan, Zongsong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplemental document
Synthesis and Evaluation of Novel Pyrazole Ethandiamide Compounds as Inhibitors of Human THP-1 Monocytic Cell Neurotoxicity
Creators: name: McKenzie, Jordan A.
name: Barghash, Reham F.
name: Alsaggaf, Azhaar T.
name: Kulkarni, Omkar
name: Boudreau, Kalun
name: Menard, Frederic
name: Neeland, Edward G.
name: Klegeris, Andis
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Neuroinflammation and microglia-mediated neurotoxicity contribute to the pathogenesis of a broad range of neurodegenerative diseases; therefore, identifying novel compounds that can suppress adverse activation of glia is an important goal. We have previously identified a class of trisubstituted pyrazoles that possess neuroprotective and anti-inflammatory properties. Here, we describe a second generation of pyrazole analogs that were designed to improve their neuroprotective activity toward neurons under inflammatory conditions. Pyrazolyl oxalamide derivatives were designed to explore the effects of steric and electronic factors. Three in vitro assays were performed to evaluate the compounds’ anti-neurotoxic, neuroprotective, and cytotoxic activity using human THP-1, PC-3, and SH-SY5Y cells. Five compounds significantly reduced the neurotoxic secretions from immune-stimulated microglia-like human THP-1 monocytic cells. One of these compounds was also found to protect SH-SY5Y neuronal cells when they were exposed to cytotoxic THP-1 cell supernatants. While one of the analogs was discarded due to its interference with the cell viability assay, most compounds were innocuous to the cultured cells at the concentrations used (1–100 μM). The new compounds reported herein provide a design template for the future development of lead candidates as novel inhibitors of neuroinflammation and neuroprotective drugs.
The Role of PRAJA2 in TSH- or Isoproterenol- Stimulated Lipolysis in Human Adipocytes
Creators: name: McBride, Arran
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: PRAJA2
TSH
Isoproterenol
Lipolysis
Adipocytes

description: Thyrotropin (TSH) binds to TSH receptors on thyrocytes to regulate development and growth of the thyroid gland, and to stimulate thyroid hormone production. Thyrotropin has also been shown to act in an extra-thyroidal fashion, and to engage TSH receptors on adipocytes to induce lipolysis, similar to the response seen by stimulation with β-adrenergic receptor agonists (i.e. isoproterenol). In both cell types, cAMP-dependent kinase (PKA) is activated. Recently, PRAJA2, a novel AKAP and E3 ubiquitin ligase that targets the regulatory subunits of PKA was identified. The ubiquitin-dependent proteasomal degradation of the PKA regulatory subunits, due to PKA- phosphorylated PRAJA2, prolongs the catalytic activity of PKA, as shown in neuroblastoma cells by Lignitto et al., 2011. In adipocytes, stimulated PKA activity is required for lipolysis. Additionally, PRAJA2 has been described to have increased expression in TSH-responsive, differentiated thyroid cancer cells when compared to anaplastic thyroid tumor (Cantara et al., 2012) The aim of this study was to characterize PRAJA2 and its potential influence on adipocyte lipolysis. These data confirm that TSH and isoproterenol stimulate lipolysis in primary human differentiated adipocytes. PRAJA2 is expressed at the mRNA and protein level in differentiated adipocytes, with no change following stimulation with TSH or isoproterenol. Stimulation with isoproterenol, but not TSH, increases PKA-dependent phosphorylation of a 122kDa (potentially PRAJA2) and 69kDa protein identified in PRAJA2 immunoprecipitates. These proteins may prove important for lipolytic signaling or other PRAJA2-dependent process in adipocytes. Experimentation was unable to identify interactions between PRAJA2 and PKAR2 in differentiated adipocytes; however further investigations are required before discounting this interaction. An attempt was made to knockdown PRAJA2 in this model, and measure effects on lipolytic response; however, this was unsuccessful. Taken together, PRAJA2 appears to be phosphorylated following β-adrenergic stimulation in human adipocytes; however, further studies are needed to delineate the specific role of PRAJA2 in this human differentiated adipocyte model.
Supplementary document for Femtosecond Laser Induced In-Situ Crystallization of Tb-Based Luminescent Metal Organic Framework - 5005229.pdf
Creators: name: liu, yanan
name: chai, nianyao
name: wang, xuewen
name: Luo, Zhijun
name: zhao, junjie
name: Xie, Changsheng
name: Mai, Liqiang
name: Gan, Zongsong
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: supplemental document
Kurzbewertung des Abschlussberichts der Kommission "Wachstum, Strukturwandel und Beschäftigung" (WSB)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: subject: Elektrizitätserzeugung
subject: Kohleausstieg
subject: Energiewende
subject: Strukturwandel
subject: Braunkohle
subject: Braunkohlerevier
subject: Kohleverstromung
subject: Braunkohleverstromung
subject: Braunkohleregion
subject: Klima | Energie

description: Mit diesem Dokument legt das Umweltbundesamt eine Kurzbewertung zum Abschlussbericht der so genannten "Kohlekommission" vor. Die Kommission wurde von der Bundesregierung eingesetzt, um konkrete Vorschläge für eine in die Zukunft gerichtete, nachhaltige Strukturentwicklung und damit für zukunftssichere Arbeitsplätze in den vom Strukturwandel betroffenen Braunkohleregionen zu erarbeiten. In ihrem Abschlussbericht empfiehlt sie unter anderem, dass Deutschland bis zum Jahr 2038 schrittweise aus der Kohleverstromung aussteigt.
Stochastic analysis of power-aware scheduling
Creators: name: Wierman, Adam
name: Andrew, Lachlan L. H.
name: Tang, Antony
Publisher: name: Swinburne
Year: 2024

description: Energy consumption in a computer system can be reduced by dynamic speed scaling, which adapts the processing speed to the current load. This paper studies the optimal way to adjust speed to balance mean response time and mean energy consumption, when jobs arrive as a Poisson process and processor sharing scheduling is used. Both bounds and asymptotics for the optimal speeds are provided. Interestingly, a simple scheme that halts when the system is idle and uses a static rate while the system is busy provides nearly the same performance as the optimal dynamic speed scaling. However, dynamic speed scaling which allocates a higher speed when more jobs are present significantly improves robustness to bursty traffic and mis-estimation of workload parameters.
Supplementary document for 3D Reconstruction of weakly scattering objects from 2D intensity-only measurements using the Wolf transform - 5005246.pdf
Creators: name: Emam, Ahmed Bassam
name: Lim, Joowon
name: Antoine, Elizabeth
name: Psaltis, Demetri
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplement 1
Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias
Creators: name: Bibl, Mirko
name: Mollenhauer, Brit
name: Lewczuk, Piotr
name: Esselmann, Hermann
name: Wolf, Stefanie
name: Otto, Markus
name: Kornhuber, Johannes
name: Rüther, Eckart
name: Wiltfang, Jens
Publisher: name: Universität Ulm
Year: 2010
Subjects: subject: Primary progressive aphasias
subject: Alzheimer’s dementia
subject: Cerebrospinal fluid
subject: Amyloid-β peptides
subject: p-Tau
subject: DDC 610 / Medicine & health
subject: Alzheimer disease
subject: Frontotemporal dementia
subject: Amyloid beta-peptides
subject: Biomarkers
subject: tau proteins
subject: Alzheimerkrankheit
subject: Frontotemporale Demenz
subject: Amyloid
subject: Liquor cerebrospinalis
subject: Biomarker
subject: Tau-Protein

description: Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ)1–38, Aβ1–40, Aβ1–42, total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer’s dementia (AD, n = 25) and nondemented controls (n = 20). Methods: Commercially available ELISA and electrochemiluminescence methods were applied. Results: High CSF p-tau and low ratios of Aβ1–42/Aβ1–40 and Aβ1–42/Aβ1–38, respectively, were specific for AD. CSF Aβ1–38 was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. Conclusion: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Book review: 'The Google story: inside the hottest business, media and technology success of our time', by David A. Vise and Mark Malseed
Creators: name: Finn, Mark
Publisher: name: Swinburne
Year: 2024

description: Review of the book 'The Google story: inside the hottest business, media and technology success of our time', by David A. Vise and Mark Malseed, published by Macmillan, London, 2005, ISBN 9780553804577.
University Libraries shaping the future of the EOSC. Sustainable support for interdisciplinary research projects through RDM services.
Creators: name: Strauch, Annette
Publisher: name: Zenodo
Year: 2020
Subjects: FAIR
FDM
Forschungsdaten
Forschungsdatenmanagement
EOSC
Forschung
Schulungen
Training

description: Strategic activities for research data management at the University of Hildesheim Foundation concern the implementation of the guidelines for handling FAIR research data, the active use of the Research Data Management Organiser (RDMO) tool for writing data management plans (DMP), consulting and training in various formats (coffee lectures and workshops). RDM at our university library as well as in others relates to the EOSC. The presentation will show how the library’s service/libraries services actively help the researchers continuously and practically in the whole process of making their research FAIR while constantly communicating together what the researchers need and how the library can help. We have incorporated FAIR in our RDM-guidelines, train researchers on metadata issues and encourage them to use FAIR data repositories. We teach research ethics and therefore also take into account CARE.1
 Further fields of activity relate to technical infrastructures as well as support with repositories and with legal issues in the research process.
 1 https://www.gida-global.org/care (09.09.2020)