cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modeling the Surface X-ray Emission and Viewing Geometry of PSR J0821-4300 in Puppis A
Creators: name: Gotthelf, E. V.
name: Perna, R.
name: Halpern, J. P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We show that a pair of thermal, antipodal hot-spots on the neutron star surface is able to fully account for the pulsar's double blackbody spectrum and energy-dependent pulse profile, including the observed 180 degree phase reversal at approximately 1.2 keV. By comparing the observed pulse modulation and phase to the model predictions, we strongly constrain the hot-spot pole (xi) and the line-of-sight (psi) angles with respect to the spin axis. For a nominal radius of R = 12 km and distance D = 2.2 kpc, we find (xi,psi) = (86d,6d), with 1-sigma error ellipse of (2d,1d); this solution is degenerate in the two angles. The best-fit spectral model for this geometry requires that the temperatures of the two emission spots differ by a factor of 2 and their areas by a factor of ~ 20. Including a cosine-beamed pattern for the emitted intensity modifies the result, decreasing the angles to (84d,3d); however this model is not statistically distinguishable from the isotropic emission case. We also present a new upper limit on the period derivative of Pdot < 3.5E-16 (2-sigma), which limits the global dipole magnetic field to B_s < 2.0E11 G, confirming PSR J0821-4300 as an "anti-magnetar." We discuss the results in the context of observations and theories of nonuniform surface temperature on isolated NSs of both weak and strong magnetic field. To explain the nonuniform temperature of PSR J0821-4300 may require a crustal field that is much stronger than the external, global dipole field.
description: 9 pages, 6 figure, Latex, emulateapj style. To appear in the Astrophysical Journal
A novel algorithm for model plant mismatch detection for model predictive controllers
Creators: name: Tsai, Yiting
Publisher: name: University of British Columbia
Year: 2016

description: For Model Predictive Controlled (MPC) plants, the quality of the plant model determines the quality of performance of the controller. Model Plant Mismatch (MPM), the discrepancies between the plant model and actual plant transfer matrix, can both improve or degrade controller “performance”, depending on the context in which “performance” is defined. Instead of using simple, “yes-no” type of performance metrics to diagnose whether MPM is present, this thesis achieves the further goal of pinpointing the exact plant inputs causing MPM. The detection method consists of a two-step identification procedure. The first experiment identifies the MPM-affected rows in the plant matrix. The second experiment pinpoints the exact inputs causing said MPM, and these MPM-affected elements are further ascertained using a hypothesis test. Finally, using input design, an estimated optimal excitation sequence is generated based on the available closed-loop data, which helps the engineer determine whether the original excitation was sufficient for the aforementioned sys-ID experiments. The most important underlying assumptions are the linear time-invariance of the plant and noise dynamics. The proposed algorithm is exercised on artificial 3x3 and 5x5 plants, then on real data from an industrial lime slaker suffering from sparse MPM, to demonstrate its ability of accurately pinpointing MPM-affected elements.
The contribution of drug import to the cost of tuberculosis treatment: A cost analysis of longer, shorter, and short drug regimens for Karakalpakstan, Uzbekistan
Creators: name: Kohler, Stefan
name: Sitali, Norman
name: Achar, Jay
name: Paul, Nicolas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: tuberculosis treatment
subject: cost
subject: cost analysis
subject: Karakalpakstan
subject: Uzbekistan
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Tuberculosis (TB) programs depend on a continuous supply of large amounts of high-quality TB drugs. When TB programs procure TB drugs from international suppliers, such as the Global Drug Facility, they can incur import costs for international transport, customs clearance, and national transport. We assessed the drug costs and import costs of 18 longer (≥18 months), 10 shorter (9-12 months), and 8 short (≤6 months) drug regimens for drug-sensitive (DS) and multidrug-resistant (MDR)-TB treatment. Costs per regimen were estimated by multiplying recommended drug amounts with 2021 Global Drug Facility prices and drug import costs of a TB program in Karakalpakstan, Uzbekistan. The standard short-course treatment of DS-TB requires taking 730 fixed-dose combination tablets, which weigh 0.79 kg and cause an import cost of $4.19 (9.8% of the regimen's drug cost of $43). A new 4-month DS-TB regimen requires taking 1358 tablets, which weigh 1.1 kg and cause an import cost of $6.07 (2.6% of the regimen's drug cost of $233). MDR-TB regimens that last between 24 weeks and 20 months involve 546-9368 tablets and injections. The drugs for these MDR-TB regimens were estimated to weigh 0.42-96 kg and cause an import cost of $2.26-507 per drug regimen (0.29-11% of a regimen's drug cost of $360-15,028). In a multivariable regression analysis, an additional treatment month increased the import cost of a drug regimen by $5.45 (95% CI: 1.65 to 9.26). Use of an injectable antibiotic in a regimen increased the import cost by $133 (95% CI: 47 to 219). The variable and potentially sizable import costs of TB regimens can affect the financial needs of TB programs. Drug regimens that are shorter and all-oral tend to reduce import costs compared to longer regimens and regimens including an injectable drug.
Varied complications of multicystic liver
Creators: name: Tonolini, Massimo
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Kidney
subject: Liver
subject: CT
subject: Percutaneous
subject: Diagnostic procedure
subject: Dilation
subject: Puncture
subject: Cysts
subject: Haemorrhage

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 88 years
description: Clinical History: Elderly woman with history of chronic congestive heart failure, diabetes, and previously treated pulmonary thromboembolism, hospitalised because of vomiting and reduced food intake for one week. Physical examination revealed non-tender mass at palpation i... Final Diagnosis: Polycystic liver disease with intrahepatic biliary obstruction, intracystic haemorrhage.
The Cauchy problem on a characteristic cone for the Einstein equations in arbitrary dimensions
Creators: name: Choquet-Bruhat, Yvonne
name: Chruściel, Piotr T.
name: Martín-García, José M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We derive explicit formulae for a set of constraints for the Einstein equations on a null hypersurface, in arbitrary dimensions. We solve these constraints and show that they provide necessary and sufficient conditions so that a spacetime solution of the Cauchy problem on a characteristic cone for the hyperbolic system of the reduced Einstein equations in wave-map gauge also satisfies the full Einstein equations. We prove a geometric uniqueness theorem for this Cauchy problem in the vacuum case.
description: 83 pages, 1 figure
Additional file 4 of Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity: a randomized crossover trial
Creators: name: Wheeler, Michael J.
name: Green, Daniel J.
name: Cerin, Ester
name: Ellis, Kathryn A.
name: Heinonen, Ilkka
name: Jaye Lewis
name: Naylor, Louise H.
name: Cohen, Neale
name: Larsen, Robyn
name: Dempsey, Paddy C.
name: Kingwell, Bronwyn A.
name: Owen, Neville
name: Dunstan, David W.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Table 2. Participant concomitant medications.
Additional file 1: of TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90Îą/uPA/MMP2 signaling pathway
Creators: name: Liu, Kai
name: Xu, Shao-Hua
name: Chen, Zhao
name: Zeng, Qing-Xin
name: Li, Zhi-Jun
name: Chen, Zhou-Miao
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. TRPM7 is an independent indicator of poor prognosis in lung cancer. (A) Kaplan-Meier analysis of TRPM7 gene expression in GSE37745 lung cancer dataset show patients with low TRPM7 expression had better overall survival than those with high TRPM7 expression. (B) Kaplan-Meier analysis of TRPM7 gene expression in GSE30219 lung cancer dataset show patients with low TRPM7 expression had longer relapse-free survival than those with high TRPM7 expression. (DOCX 184 kb)
Study of Single W production in e-gamma collisions through the decay lepton spectrum to probe gamma-WW couplings
Creators: name: Kumar, Satendra
name: Poulose, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the effect of anomalous gamma-W-W couplings in e-gamma --> nu W through the angular and energy spectrum of the secondary leptons. Within the narrow-width approximation, a semi-analytical study of the secondary lepton energy-angle double distribution is considered. Utility of observables derived from this is demonstrated by considering the anomalous coupling, delta-kappa-gamma. Results of our investigation for typical ILC machine considered at Ecm = 300-1000 GeV re-affirms potential of this collider as a precision machine.
description: Typos corrected, discussion added in section 2 for clarity, error in fig.2 corrected, figures 7 and 8 replaced with better resolution
A MRI / MRCP diagnosis you canât miss: multiple bile duct hamartomas
Creators: name: Tonolini, Massimo
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Biliary Tract / Gallbladder
subject: MR
subject: Cholangiography
subject: Congenital
subject: Cysts

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 38 years
description: Clinical History: Asymptomatic middle-aged male patient with unremarkable past medical history and physical examination, referred for further investigation of incidental sonographic detection at an outpatient facility of âmultiple hepatic cystsâ. No significant l... Final Diagnosis: Multiple bile duct hamartomas (von Meyenburg complexes)
Feedback, fairness, and validity: effects of disclosing and reusing multiple-choice questions in medical schools
Creators: name: Appelhaus, Stefan
name: Werner, Susanne
name: Grosse, Pascal
name: Kämmer, Juliane E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Assessment
subject: formative assessment
subject: multiple-choice questions
subject: item reuse
subject: disclosure
subject: feedback
subject: progress testing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Disclosure of items used in multiple-choice-question (MCQ) exams may decrease student anxiety and improve transparency, feedback, and test-enhanced learning but potentially compromises the reliability and fairness of exams if items are eventually reused. Evidence regarding whether disclosure and reuse of test items change item psychometrics is scarce and inconclusive. Methods: We retrospectively analysed difficulty and discrimination coefficients of 10,148 MCQ items used between fall 2017 and fall 2019 in a large European medical school in which items were disclosed from fall 2017 onwards. We categorised items as 'new'; 'reused, not disclosed'; or 'reused, disclosed'. For reused items, we calculated the difference from their first ever use, that is, when they were new. Differences between categories and terms were analysed with one-way analyses of variance and independent-samples t tests. Results: The proportion of reused, disclosed items grew from 0% to 48.4%; mean difficulty coefficients increased from 0.70 to 0.76; that is, items became easier, P < .001, eta(p) (2) = 0.011. On average, reused, disclosed items were significantly easier (M = 0.83) than reused, not disclosed items (M = 0.71) and entirely new items (M = 0.66), P < .001, eta(p) (2) = 0.087. Mean discrimination coefficients increased from 0.21 to 0.23; that is, item became slightly more discriminating, P = .002, eta(p) (2) = 0.002. Conclusions: Disclosing test items provides the opportunity to enhance feedback and transparency in MCQ exams but potentially at the expense of decreased item reliability. Discrimination was positively affected. Our study may help weigh advantages and disadvantages of using previously disclosed items.
Toolbox model of evolution of prokaryotic metabolic networks and their regulation
Creators: name: Maslov, Sergei
name: Krishna, Sandeep
name: Pang, Tin Yau
name: Sneppen, Kim
Publisher: name: arXiv
Year: 2010
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Genomics (q-bio.GN)
subject: Populations and Evolution (q-bio.PE)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Biological sciences

description: It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes. We propose a conceptual explanation of this finding and illustrate it using a simple model in which metabolic and regulatory networks of prokaryotes are shaped by horizontal gene transfer of coregulated metabolic pathways. Adapting to a new environmental condition monitored by a new transcription factor (e.g., learning to use another nutrient) involves both acquiring new enzymes and reusing some of the enzymes already encoded in the genome. As the repertoire of enzymes of an organism (its toolbox) grows larger, it can reuse its enzyme tools more often and thus needs to get fewer new ones to master each new task. From this observation, it logically follows that the number of functional tasks and their regulators increases faster than linearly with the total number of genes encoding enzymes. Genomes can also shrink, e.g., because of a loss of a nutrient from the environment, followed by deletion of its regulator and all enzymes that become redundant. We propose several simple models of network evolution elaborating on this toolbox argument and reproducing the empirically observed quadratic scaling. The distribution of lengths of pathway branches in our model agrees with that of the real-life metabolic network of Escherichia coli. Thus, our model provides a qualitative explanation for broad distributions of regulon sizes in prokaryotes.
description: 6 pages, 4 figures
Pulmonary polymethyl methacrylate (PMMA) - cement embolism
Creators: name: Weerakkody, Yuranga
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Thoracic wall
subject: Thorax
subject: CT
subject: Education
subject: Pathology

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 80 years
description: Clinical History: An 85-year-old female patient, with a background history of vertebroplasty for compression fractures, presented with a subacute history of shortness of breath. She was investigated with a CT scan of the chest. Final Diagnosis: Pulmonary polymethyl methacrylate (PMMA) - cement embolism
Additional file 4 of Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis
Creators: name: Cheng, Zhengpei
name: Gu, Rui
name: Lian, Zenglin
name: Gu, Harvest F.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4.
Type of vaccine and immunosuppressive therapy but not diagnosis critically influence antibody response after COVID-19 vaccination in patients with rheumatic disease
Creators: name: Frommert, Leonie Maria
name: Arumahandi De Silva, Amanthi Nadira
name: Zernicke, Jan
name: Scholz, Veronika
name: Braun, Tanja
name: Jeworowski, Lara Maria
name: Schwarz, Tatjana
name: Tober-Lau, Pinkus
name: Ten Hagen, Alexander
name: Habermann, Elisa
name: Kurth, Florian
name: Sander, Leif Erik
name: Corman, Victor Max
name: Burmester, Gerd-Rüdiger
name: Biesen, Robert
name: Albach, Fredrik N.
name: Klotsche, Jens
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: rituximab
subject: COVID-19
subject: vaccination
subject: autoimmune diseases
subject: arthritis
subject: rheumatoid
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: The development of sufficient COVID-19 vaccines has been a big breakthrough in fighting the global SARS-CoV-2 pandemic. However, vaccination effectiveness can be reduced in patients with autoimmune rheumatic diseases (AIRD). The aim of this study was to identify factors that lead to a diminished humoral vaccination response in patients with AIRD. Methods: Vaccination response was measured with a surrogate virus neutralisation test and by testing for antibodies directed against the receptor-binding-domain (RBD) of SARS-CoV-2 in 308 fully vaccinated patients with AIRD. In addition, 296 immunocompetent participants were investigated as a control group. Statistical adjusted analysis included covariates with a possible influence on antibody response. Results: Patients with AIRD showed lower antibody responses compared with immunocompetent individuals (median neutralising capacity 90.8% vs 96.5%, p<0.001; median anti-RBD-IgG 5.6 S/CO vs 6.7 S/CO, p<0.001). Lower antibody response was significantly influenced by type of immunosuppressive therapy, but not by rheumatic diagnosis, with patients under rituximab therapy developing the lowest antibody levels. Patients receiving mycophenolate, methotrexate or janus kinase inhibitors also showed reduced vaccination responses. Additional negative influencing factors were vaccination with AZD1222, old age and shorter intervals between the first two vaccinations. Conclusion: Certain immunosuppressive therapies are associated with lower antibody responses after vaccination. Additional factors such as vaccine type, age and vaccination interval should be taken into account. We recommend antibody testing in at-risk patients with AIRD and emphasise the importance of booster vaccinations in these patients.
Additional file 5 of Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis
Creators: name: Cheng, Zhengpei
name: Gu, Rui
name: Lian, Zenglin
name: Gu, Harvest F.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5.
A pitfall case of  endometrial serous adenocarcinoma
Creators: name: Delgado, Lara
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Diagnostic procedure
subject: Staging
subject: Neoplasia
subject: Tissue characterisation

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 78 years
description: Clinical History: A 78-year-old-woman presented with a 6-month history of metrorrhagia and pelvic pain. The past medical history was unknown. The patient was referred for a pelvic ultrasound examination and, subsequently, a pelvic magnetic resonance imaging (MRI) was perfo... Final Diagnosis: Serous adenocarcinoma of the endometrium.
A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity
Creators: name: Müller, Paul Markus
name: Rocks, Oliver
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Chemistry
subject: Energy
subject: Environmental sciences
subject: Material sciences
subject: Physics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Rho family GTPases are central regulators of cytoskeletal dynamics controlled by guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). This protocol presents a workflow for a robust high-throughput compatible biosensor assay to analyze changes in Rho GTPase activity by these proteins in the native cellular environment. The procedure can be used for semi-quantitative comparison of GEF/GAP function and extended for analysis of additional modulators. The experimental design is applicable also to other monomolecular ratiometric FRET sensors. For complete details on the use and execution of this protocol, please refer to Müller et al. (2020).
Professor Karl Keller, geb. 24. Mai 1814, gest. 6. Juli 1878, Professor August Menzel, geb. 27. August 1810, gest. 16. Dezember 1878, Dr. Wilhelm Berthold, geb. 20. September 1811, gest. 26. März 1879
Creators: name: (:Unkn) Unknown
Publisher: name: [Zürcher & Furrer]
Year: 1879
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Keller, Karl
subject: Menzel, August
subject: Berthold, Wilhelm

description: Separatabdruck aus dem Programm der Zürcher Kantonsschule vom Jahr 1879
Additional file 3 of Quantitative assessment of the impact of cryopreservation on human bone marrow-derived mesenchymal stem cells: up to 24 h post-thaw and beyond
Creators: name: Bahsoun, Soukaina
name: Coopman, Karen
name: Akam, Elizabeth C.
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 3. For chondrogenic differentiation, cells were centrifuged, and supernatant completely removed to obtain a cell pellet. 3x5μL droplets of concentrated cells were added to 12-well plate. The generated micro-masses were incubated for about an hour in a humidified incubator to allow attachment. After incubation, 1 mL/well of differentiation media was added. The differentiation media consisted of 100 nM dexamethasone, 10% ITS-Premix (Sigma, UK), 1 μg/mL ascorbic acid, 1% sodium pyruvate (Sigma, UK) and 10 ng/mL Human TGFβ1 (R&D systems, UK) in DMEM high glucose. At day 21 in culture, cells were fixed by incubating with paraformaldheyde then stained with filtered (1%w/v) Alcian Blue (Sigma, UK) in Hydrochloric acid. After one-hour incubation with the stain, wells were washed twice with distilled water and then imaged (Figure S16). Figure S16. Alcian Blue staining of fresh cells following 21 days of incubation with chondrogenic differentiation media: Representative images: (A) M4 cell line, (B) M6 cell line and (C) M7 cell line. Scale bars represent 100 μm.
Clinical Practice Patterns in Tic Disorders Among Movement Disorder Society Members
Creators: name: Ganos, Christos
name: Sarva, Harini
name: Kurvits, Lille
name: Gilbert, Donald L.
name: Hartmann, Andreas
name: Worbe, Yulia
name: Mir, Pablo
name: Müller-Vahl, Kirsten R.
name: Münchau, Alexander
name: Shprecher, David
name: Singer, Harvey S.
name: Deeb, Wissam
name: Okun, Michael S.
name: Malaty, Irene A.
name: Hallett, Mark
name: Tijssen, Marina AJ
name: Pringsheim, Tamara
name: Martino, Davide
name: Tic Disorders And Tourette Syndrome Study Group Of The International Parkinson And Movement Disorder Society
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Tic disorders
subject: Tourette disorder
subject: Survey
subject: Tic Disorders and Tourette Syndrome Study Group
subject: Movement Disorder Society
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Tic disorders belong to the broad spectrum of pediatric and adult movement disorders. The wide variability in clinical presentations, applied assessment tools, and treatments are poorly understood. Objectives: To map practices and knowledge base of movement disorder clinicians concerning clinical features, pathophysiology, and treatment approaches in tic disorders. Methods: A 33-item survey was developed by the Tic Disorders and Tourette syndrome Study Group members of the Movement Disorder Society. The survey was distributed to the complete society membership and included responses from 346 members, 314 of whom reported treating tic disorders. Results: Approximately one third of survey respondents (35%) frequently evaluated patients with tics. The data revealed widespread use of existing guidelines (about 70%) and screening for comorbid disorders (>90%). The most common investigations used to rule out secondary causes of tics were imaging (92%), laboratory tests (66%) and neurophysiology (38%). Functional tics were the second most common tic etiology following primary tics. Only 27% of respondents reported confidence in knowledge about tic pathogenesis. Top rated interventions to treat tics were psychoeducation, cognitive behavioral intervention for tics (CBIT) and treatment for neuropsychiatric comorbidities. Antipsychotics were ranked as the most effective pharmacologic tic intervention. Conclusions: The majority of movement disorders specialists do not frequently encounter tics. There was sparse knowledge about tic pathophysiology. Psychoeducation, CBIT, the treatment of neuropsychiatric comorbidities and use of antipsychotics emerged as the most common interventions to treat tics. These results provide insight into what will be needed to improve the diagnosis and treatment of tic disorders.
Adult-type fibrosarcoma in a female patient of 17 years of age
Creators: name: Rossi, Piercarlo
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Abdomen
subject: Kidney
subject: Liver
subject: Oncology
subject: Paediatric
subject: Pelvis
subject: CT
subject: MR
subject: PET
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Staging
subject: Treatment effects
subject: Dilatation
subject: Metastases
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 17 years
description: Clinical History: A 17-year-old woman came to our attention for the recent onset of abdominal pain, urinary disorders and change in bowel habit. Final Diagnosis: Adult-type fibrosarcoma
Tracing the sources of cosmic rays with molecular ions
Creators: name: Becker, J. K.
name: Black, J. H.
name: Safarzadeh, M.
name: Schuppan, F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The rate of ionization by cosmic rays in interstellar gas directly associated with gamma-ray emitting supernova remnants is for the first time calculated to be several orders of magnitude larger than the Galactic average. Analysis of ionization-induced chemistry yields the first quantitative prediction of the astrophysical H_{2}^{+} emission line spectrum, which should be detectable together with H_3^+ lines. The predicted coincident observation of those emission lines and gamma-rays will help prove that supernova remnants are sources of cosmic rays.
description: 11 pages, 2 figures
Additional file 1 of Psychometric properties of a clinical reasoning assessment rubric for nursing education
Creators: name: Lee, JuHee
name: Park, Chang Gi
name: Kim, Sung Hae
name: Bae, Juyeon
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Additional file 1. Case vignette.
A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
Creators: name: Jeitler, Michael
name: Lauche, Romy
name: Hohmann, Christoph
name: Choi, Kyung-Eun (Anna)
name: Schneider, Nadia
name: Steckhan, Nico
name: Rathjens, Florian
name: Anheyer, Dennis
name: Paul, Anna
name: Scheidt, Christel Von
name: Ostermann, Thomas
name: Schneider, Elisabeth
name: Koppold-Liebscher, Daniela
name: Kessler, Christian S.
name: Dobos, Gustav
name: Michalsen, Andreas
name: Cramer, Holger
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: fasting
subject: metabolic syndrome
subject: modified DASH diet
subject: Mediterranean diet
subject: lifestyle
subject: relaxation
subject: mindfulness
subject: MICOM (Mind-Body Medicine in Integrative and Complementary Medicine)
subject: self-efficacy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 +/- 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups-only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.
The knee in the cosmic ray energy spectrum: a pulsar/supernova origin?
Creators: name: Wibig, Tadeusz
name: Wolfendale, Arnold W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The origin of the prominent 'knee' in the cosmic ray energy spectrum at an energy of several PeV is still uncertain. A recent mechanism has shown promise, however; this involves particles from a very young pulsar interacting with the radiation field from a very young supernova remnant. The ensuing nuclear reaction of the particles with the photons by way of e+e- production then causes the characteristic knee. In an earlier paper we argued that the mechanism would imply only one source of a very rare type - if it were to explain the spectral shape. Here we examine the mechanism in more detail and conclude that for even a single source to work its characteristics would need to be so unusual that the mechanism would not be possible for any known type of pulsar-supernova combination.
A patient with haemophilic haemarthrosis and arthropathy
Creators: name: Nascimento, Duarte
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Bones
subject: Conventional radiography
subject: MR
subject: Plain radiographic studies
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Haematologic diseases

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 13 years
description: Clinical History: A 13-year-old boy came to the emergency department with swelling and marked local inflammation of the right knee lasting for one week. His father referred a history of haemophilia with recurrent episodes of right knee swelling and also a previous su... Final Diagnosis: Haemophilic arthropathy and hemarthrosis
Patient with a high riding scapula
Creators: name: Nascimento, Duarte
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: Digital radiography
subject: MR
subject: Diagnostic procedure
subject: Congenital

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 6 years
description: Clinical History: 6 year old boy with short neck, head and neck deviation to the left side, shoulder asymmetry and limitations of left shoulder movements in abduction and elevation. Final Diagnosis: KlippelâFeil syndrome with an assotiated Sprengel Deformity
Dentocutaneous sinus tract presenting as a chronic discharging nodule in the skin overlying the jaw
Creators: name: ZINDHA, ASHIQ
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Head and neck
subject: CT
subject: Diagnostic procedure
subject: Abscess
subject: Fistula
subject: Infection

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 33 years
description: Clinical History: A 33-year-old male patient presented with a nodule in the right side of the face, close to the region of the angle of the mandible. He gave a history of intermittent purulent discharge from this nodule for the past 6 months. The discharge had persisted ev... Final Diagnosis: Dentocutaneous fistula from a periapical abscess involving second molar tooth.
Women and political influence : evidence from local elections in the Philippines
Creators: name: Tolentino, Charis Mae A.
Publisher: name: University of British Columbia
Year: 2016

description: In terms of female political leadership, the Philippines is one of the most progressive countries in Asia. At the same time, these rankings and statistics focus largely on holding national office, which masks broader problems with women’s participation at the local level. For example, Labonne, Parsa, and Querubin (2016) find that the increasing number of women in Philippine national politics is largely driven by political dynasties, rather than an expansion of opportunities for women to participate in politics. As a result, while there are certainly many women in the legislature, these women tend to reflect the policy preferences and political platforms of their relatives and do not represent new voices in the decision-making process. In order to increase not only the number of women in politics but also the opportunity for new women to enter politics, it is important to understand the underlying dynamics driving gender and political influence at the local level, because it is the primary entry point for new, non-dynastic candidates in the political system. Using household-level data collected through a survey of 284 villages in 12 municipalities after the 2013 local elections in the Philippines, this analysis shows that women are less likely to be politically influential than men even at the local village level, an effect that is driven by gender differences in recognizing influence and in socioeconomic factors that affect the ability to participate in politics. This is important because there are gender differences in policy preferences and political views. From a policy standpoint, this thesis has three main contributions: 1) providing a methodology for identifying politically influential women at the local level; 2) analyzing the differences in policies and profiles between influential men and women; and 3) linking the determinants of political influence to policy recommendations for promoting and supporting these women to enable them to better participate in the political sphere. In order for women to have a voice in Philippine politics, it is not enough to have more women holding office on paper, but to ensure that women are given the same opportunities and avenues for participation in politics.
Mesoblastic nephroma
Creators: name: Reaney, Jonathan
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Kidney
subject: Paediatric
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Screening
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 4 weeks
description: Clinical History: Born at 36 weeks gestation via emergency caesarean section. A right-sided abdominal mass was noted on physical examination. The patient was clinically hypertensive and subsequently developed severe hypercalcaemia with a peak corrected Calcium of 4.26mmol/... Final Diagnosis: Congenital mesoblastic nephroma
Behavioral factors predict all-cause mortality in female coronary patients and healthy controls over 26 years – a prospective secondary analysis of the Stockholm Female Coronary Risk Study
Creators: name: Deter, Hans-Christian
name: Meister, Reinhard
name: Leineweber, Constanze
name: Kecklund, Göran
name: Lohse, Lukas
name: Orth-Gomér, Kristina
name: Fem-Cor-Risk Study Group
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: coronary artery disease (CAD)
subject: female patients after 26 years
subject: behavioral factors
subject: mortality
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: The prognosis of coronary artery disease (CAD) is related to its severity and cardiovascular risk factors in both sexes. In women, social isolation, marital stress, sedentary lifestyle and depression predicted CAD progression and outcome within 3 to 5 years. We hypothesised that these behavioral factors would still be associated with all-cause mortality in female patients after 26 years. Methods: We examined 292 patients with CAD and 300 healthy controls (mean age of 56 7 y) within the Fem-Cor-Risk-Study at baseline. Their cardiac, behavioral, and psychosocial risk profiles, exercise, smoking, and dietary habits were assessed using standardized procedures. Physiological characteristics included a full lipid profile, the coagulation cascade and autonomic dysfunction (heart rate variability, HRV). A new exploratory analysis using machine-learning algorithms compared the effects of social and behavioral mechanisms with standard risk factors. Results: All-cause mortality records were completed in 286 (97.9%) patients and 299 (99.7%) healthy women. During a median follow-up of 26 years, 158 (55.2%) patients and 101 (33.9%) matched healthy controls died. The annualized mortality rate was 2.1% and 1.3%, respectively. After controlling for all available confounders, behavioral predictors of survival in patients were social integration (HR 0.99, 95% CI 0.99-1.0) and physical activity (HR 0.54, 95% CI 0.37-0.79). Smoking acted as a predictor of all-cause mortality (HR 1.56, 95% CI 1.03-2.36). Among healthy women, moderate physical activity (HR 0.42, 95% CI 0.24-0.74) and complete HRV recordings (>= 50%) were found to be significant predictors of survival. Conclusions: CAD patients with adequate social integration, who do not smoke and are physically active, have a favorable long-term prognosis. The exact survival times confirm that behavioral risk factors are associated with all-cause mortality in female CAD patients and healthy controls.
Additional file 9 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
Creators: name: Zeng, Zhenhao
name: He, Wenrui
name: Jiang, Yi
name: Jiang, Hao
name: Cheng, Xiaofeng
name: Deng, Wen
name: Zhou, Xiaochen
name: Zhang, Cheng
name: Wang, Gongxian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 9 Table S4. Univariate and multivariate Cox regression analyses of MAPK8IP2 and its partners genes predict progression-free interval in PCa.
Work-life balance in physicians working in two emergency departments of a university hospital: Results of a qualitative focus group study
Creators: name: Pudasaini, Samipa
name: Schenk, Liane
name: Möckel, Martin
name: Schneider, Anna
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Work-life balance
subject: emergency departments
subject: physicians
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: By applying an explorative approach, we aimed to identify a wide set of challenges and opportunities for the compatibility of the work and life domains in emergency department (ED) physicians as well as their suggestions for practical approaches to improve work-life balance. Four focus groups with 14 physicians of differing hierarchical position and family status were carried out at two EDs of one major university hospital. Data analysis was based on qualitative content analysis. Discussed themes within main categories included ED work conditions, aspects of residency training, physician's mentality and behaviors as well as context factors of university medicine. Working in an ED is associated with a comparatively high work-life-interference, mostly due to the unpredictable nature of ED work. Based on our context-specific findings, further research might address factors influencing work-life balance in ED physicians with a mixed-methods approach for identification of relevant associations and intervention approaches in this field.
Two distinct halo populations in the solar neighborhood. II. Evidence from stellar abundances of Mn, Cu, Zn, Y, and Ba
Creators: name: Nissen, Poul E.
name: Schuster, William J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A previous study (Nissen & Schuster 2010) of 94 dwarf stars with -1.6 < [Fe/H] < -0.4 has revealed the existence of two distinct halo populations with a systematic difference in [alpha/Fe] at a given metallicity. In continuation of that work, abundances of Mn, Cu, Zn, Y, and Ba are determined for the same sample of stars. Equivalent widths of atomic lines are measured from high resolution VLT/UVES and NOT/FIES spectra and used to derive precise abundance ratios from an LTE analysis based on MARCS model atmospheres. Systematic differences between the `high-alpha' and `low-alpha' halo populations are found for [Cu/Fe], [Zn/Fe], and [Ba/Y], whereas there is no significant difference in the case of [Mn/Fe]. At a given metallicity, [Cu/Fe] shows a large scatter that is closely correlated with a corresponding scatter in [Na/Fe] and [Ni/Fe]. The metallicity trends of [Cu/Fe], [Zn/Fe], and [Ba/Y] can be explained from existing nucleosynthesis calculations if the high-alpha stars formed in regions with such a high star formation rate that only massive stars and Type II supernovae contributed to the chemical enrichment. The low-alpha stars, on the other hand, most likely originate from systems with a slower chemical evolution, characterized by additional enrichment from Type Ia supernovae and low-mass AGB stars.
description: Accepted for publication in A&A
Adjusting to the debris : a phenomenology of exile
Creators: name: Aslanimehr, Parmis
Publisher: name: University of British Columbia
Year: 2016

description: This thesis will address the difficulties children of newcomer families face as they transition to life in a multicultural country like Canada. As immigrant families represented about 39 percent of total immigrant landings in British Columbia in 2013, there is an increasing need to accumulate knowledge about the development and adjustment of the children from this population. The lives of First Generation immigrant children are marked by dramatic adjustments due to difficulties with language, family dislocation and culture shock. The following will examine the current approach of the BC Ministry of Education in its aim to make newcomer students feel at home- and thus, adjusted. The underlying question of this research investigates whether adjustment should, in fact, be the end goal of newcomers? And what critical aspects of the lifeworld of newcomers are neglected when the aim is to cultivate acculturated individuals? In answering this question, this thesis will first analyze how adjustment is defined in the domains of dominating theories, current research, as well as pedagogical practices geared towards newcomers. It will be illustrated that the majority of studies dedicated to immigrant children has overlooked the emotional experiences in navigating the education system, and has instead opted to measure proficiency in the English language as a marker of adjustment. Yet the struggles of newcomer children run much deeper. In a phenomenological exploration of adjustment and critiquing its necessity as an aim for both policymakers and newcomers, the ideas of three authors, Søren Kierkegaard, Mikhail Bakhtin and Homi Bhabha will shed light on the lifeworld of immigrant children in order to propose a new approach to the recognition of this group. This thesis can enhance the understanding of educational leaders when it comes to addressing diversity in education, for they are in a favorable position to acknowledge the struggles children must face in bridging their past and present experiences, and to incorporate them into strategies to counteract the many negative experiences they may be receiving in education.
Additional file 1 of Skin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus
Creators: name: Bjerre, Rie Dybboe
name: Holm, Jacob Bak
name: Palleja, Albert
name: Sølberg, Julie
name: Skov, Lone
name: Johansen, Jeanne Duus
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1.