cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Antimicrobial Peptide, LL-37, Inhibits in vitro Osteoclastogenesis
Creators: name: Supanchart, C.
name: Thawanaphong, S.
name: Makeudom, A.
name: Bolscher, J. G.
name: Nazmi, K.
name: Kornak, U.
name: Krisanaprakornkit, S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2012
Subjects: subject: bone resorption
subject: cathelicidin
subject: innate immunity
subject: nuclear factor of activated T-cells
subject: osteoimmunity
subject: periodontal disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Uncoupled bone resorption leads to net alveolar bone loss in periodontitis. The deficiency of LL-37, the only human antimicrobial peptide in the cathelicidin family, in patients with aggressive periodontitis suggests that LL-37 may play a pivotal role in the inhibition of alveolar bone destruction in periodontitis. We aimed to investigate a novel function of LL-37 in osteoimmunity by blocking osteoclastogenesis in vitro. Human osteoclast progenitor cells were isolated from a buffy coat of blood samples. The cells were cultured in the presence of various concentrations of LL-37 during an in vitro induction of osteoclastogenesis. Non-toxic doses of LL-37 could block multinuclear formation of the progenitor cells and significantly diminish the number of tartrate-resistant acid-phosphatase-positive cells and the formation of resorption pits (p < 0.05), whereas these concentrations induced cellular proliferation, as demonstrated by increased expression of proliferating cell nuclear antigen. Expression of several osteoclast genes was down-regulated by LL-37 treatment. It was demonstrated that nuclear translocation of nuclear- factor-activated T-cells 2 (NFAT2) was blocked by LL-37 treatment, consistent with a significant reduction in the calcineurin activity (p < 0.005). Collectively, our findings demonstrate that LL-37 inhibits the in vitro osteoclastogenesis by inhibiting the calcineurin activity, thus preventing nuclear translocation of NFAT2. Abbreviations: CALCR, calcitonin receptor; ClC-7, chloride-proton exchanger; CTSK, cathepsin K; DAPI, 4′,6-diamidino-2-phenylindole; EGTA, ethylene glycol tetraacetic acid; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; M-CSF/CSF1, macrophage-colony- stimulating factor; MMP-9, matrix metalloproteinase-9; MTT, [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]; NFAT2, nuclear factor of activated T-cells 2; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PCR, polymerase chain reaction; RANK, receptor activator of nuclear factor kappa-B; RANKL, receptor activator of nuclear factor kappa-B ligand; RT-PCR, reverse-transcription polymerase chain- reaction; TBS, Tris-buffered saline; TCIRG1, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TRAcP, tartrate-resistant acid phosphatase.
MRO Procurement for Business Customers: A Longitudinal Case Study Analysis
Creators: name: Schubert, Petra
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2006
Subjects: subject: Case Study
subject: E-Business
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Buero-Fuerrer is a company that decided to implement a modern e-procurement solution for B2B customers in the industry of office supplies. The company was looking for an e-commerce software solution for the seamless integration of the procurement process for its business customers. The main objective was the development of a customized software solution which would have a major impact on customer retention and the way procurement processes were handled. Buero-Fuerrer can be called as visionary regarding the consequent implementation of its e-strategy. What was originally seen as a challenge and "nice to have" venture is now the preferred sales channel and an absolute key to market success. Without an e-shop, Buero-Fuerrer would not have managed to become number one in the Swiss B2B stationary market.
Investigating the influence of various operational parameters on the energy storage capacity of an Active Phase Change Material System in buildings
Creators: name: Devapriya, Shyan
Publisher: name: Swinburne
Year: 2024

description: Phase Change Materials (PCM) are reported to achieve massive energy savings in buildings. However, in real-life scenarios, the results vary from the theoretical or experimental results. This study investigated the causes of poor energy savings and inefficiencies of an active PCM system installed in an eleven-storey educational building in Melbourne, Australia. The key design and operation parameters that affect the energy saving performance of the active PCM system were identified. Then, using a small-scale model of the system, this study experimentally investigated the influence of these parameters on the melting, solidification and energy storage of an active PCM system.
3173779.pdf
Creators: name: Li, Lan
name: Lin, Hongtao
name: Huang, Yizhong
name: Shiue, Ren-Jye
name: Yadav, Anupama
name: Li, Junying
name: Michon, Jerome
name: Englund, Dirk
name: Richardson, Kathleen
name: Gu, Tian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Material
The Compost Connection for Washington Agriculture, June 1996
Creators: name: Granatstein, David
Publisher: name: Washington State University Cooperative Extension
Year: 1996
Subjects: composting
Agriculture

description: Commercial growers in Washington State are using an increasing amount of compost in their farming operations. One of the more popular crops for compost is tree fruits in central Washington. According to an informal survey, over 2,000 tons of compost were imported into north-central Washington in 1994 for use on commercial orchards.
Seeds for Thought, November 2023
Creators: name: Master Gardener Foundation Of Washington State
Publisher: name: Washington State University
Year: 2023
Subjects: Horticulture

description: This newsletter article includes:
description: From the President
description: 2023 Awards
description: Christmas is Coming! The WSU Master Gardener Store is Open
description: Free Membership to Pacific Horticulture
description: Making A Difference… Three Gardens At A Time
description: Winter Solstice in the Garden
description: 2023 WSU Master Gardener Advanced Education Conference
description: Spokane’s Newest Demonstration Gardens
description: Thurston County MG Foundation partners on Schmidt House Centennial Rose Garden.
description: Yakima Valley Fair Educational Display
What makes a high impact research team? The role of multidisciplinarity
Creators: name: Desvignes, Jean-Francois
Publisher: name: Swinburne
Year: 2024

description: This dissertation asks what makes a high impact research team, focusing on the role of multidiciplinarity of the research experience of the team members. I shed new light on this question by analysing collaborations between individual researchers in teams and their citations. I use novel identification of teams from disambiguated data and citation estimate for multidisciplinary research output. The role of science in economic growth is central. In a context in which scientific teams are an important component of scientific research, efficiencies created from teams increase the return on investment in science.
Development and validation of a Score for Preoperative Prediction of Obstructive Sleep Apnea (SPOSA) and its perioperative outcomes
Creators: name: Shin, Christina H.
name: Grabitz, Stephanie D.
name: Timm, Fanny P.
name: Mueller, Noomi
name: Chhangani, Khushi
name: Ladha, Karim
name: Devine, Scott
name: Kurth, Tobias
name: Eikermann, Matthias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Perioperative obstructive sleep apnea
subject: Prediction
subject: Outcomes
subject: Postoperative respiratory complications
subject: In-hospital mortality
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Postoperative respiratory complications (PRCs) are associated with significant morbidity, mortality, and hospital costs. Obstructive sleep apnea (OSA), often undiagnosed in the surgical population, may be a contributing factor. Thus, we aimed to develop and validate a score for preoperative prediction of OSA (SPOSA) based on data available in electronic medical records preoperatively. Methods OSA was defined as the occurrence of an OSA diagnostic code preceded by a polysomnography procedure. A priori defined variables were analyzed by multivariable logistic regression analysis to develop our score. Score validity was assessed by investigating the score’s ability to predict non-invasive ventilation. We then assessed the effect of high OSA risk, as defined by SPOSA, on PRCs within seven postoperative days and in-hospital mortality. Results A total of 108,781 surgical patients at Partners HealthCare hospitals (2007–2014) were studied. Predictors of OSA included BMI >25 kg*m−2 and comorbidities, including pulmonary hypertension, hypertension, and diabetes. The score yielded an area under the curve of 0.82. Non-invasive ventilation was significantly associated with high OSA risk (OR 1.44, 95% CI 1.22–1.69). Using a dichotomized endpoint, 26,968 (24.8%) patients were identified as high risk for OSA and 7.9% of these patients experienced PRCs. OSA risk was significantly associated with PRCs (OR 1.30, 95% CI 1.19–1.43). Conclusion SPOSA identifies patients at high risk for OSA using electronic medical record-derived data. High risk of OSA is associated with the occurrence of PRCs.
Salvaging the Self: The Selfie’s Reclamation of the Unified Self in a Postmodern World
Creators: name: Chua, Gloria
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: College students' writings, selfie, postmodernity, fragmentation, self-portraiture, popular culture, rhetoric

description: This essay won or received an honorable mention for The Boothe Prize for excellence in first-year writing. The Boothe Prize recognizes and rewards outstanding expository and argumentative writing by undergraduate students in first-year classes that satisfy the WR 1 requirement. In each award-winning essay, student writers demonstrate clarity of argument, excellent integration of research-based evidence, and compelling prose style.
This essay redefines the selfie, urging us to see both the artifact itself and the motivation that produces it from a new perspective. She proposes that in our diffuse postmodern world where the very notion of the unified self is being challenged, the selfie—often presenting in a series of random snapshots taken across time and space and informed by the disjunct messages of mass culture—facilitates a composite portrait that is at once an attempt to salvage the self and an acknowledgement of the fragmentation of our times.
IMPACTS OF GENDER ON JOB SATISFACTION AND WORK MOTIVATION RELATIONSHIP: A CASE OF TEACHERS IN BALOCHISTAN, PAKISTAN
Creators: name: Abdul Raziq, Raja M. Ilyas
Publisher: name: TuEngr Group
Year: 2019
Subjects: Job satisfaction
Work satisfaction-motivation relationship
Hierarchical Regression Analysis
Moderating Effect
Gender impact on job satisfaction
Teacher's job satisfaction.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 13, 10A13F: 1-10
Fallstudie Schindler Aufzüge AG
Creators: name: Tanner, Christian
name: Perruchoud, Antoine
Publisher: name: Hanser
Year: 2002
Subjects: subject: E-Business
subject: E-Procurement
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Schindler Aufzüge AG ist ein Tochterunternehmen des Schweizerischen Schindler Konzerns, dem weltweit zweitgrössten Anbieter für Aufzüge und Fahrtreppen. Auf der Suche nach Optimierungspotenzialen in der Beschaffung sammelte die Abteilung Strategische Beschaffung im Jahr 2001 erstmals Erfahrungen in der Durchführung einer Online-Einkaufsauktion. Für die webbasierte Verhandlung der Konditionen mit fünf Lieferanten für Antriebskomponenten wurden die Auktionsplattform und die Dienste von Conextrade eingesetzt. Die Konzeption, der Verlauf und die Erfahrungen mit dieser neuen Verhandlungsform sind Gegenstand dieser Fallstudie.
The High Time Resolution Universe pulsar survey - X. Discovery of four millisecond pulsars and updated timing solutions of a further 12
Creators: name: Ng, C.
name: Bailes, Matthew
name: Bates, S. D.
name: Bhat, N. D. R.
name: Burgay, M.
name: Burke-Spolaor, S.
name: Champion, D. J.
name: Coster, P.
name: Johnston, S.
name: Keith, M. J.
name: Kramer, M.
name: Levin, L.
name: Petroff, E.
name: Possenti, A.
name: Stappers, B. W.
name: van Straten, Willem
name: Thornton, D.
name: Tiburzi, C.
name: Bassa, C. G.
name: Freire, P. C. C.
name: Guillemot, L.
name: Lyne, A. G.
name: Tauris, T. M.
name: Shannon, Ryan
name: Wex, N.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 5101
subject: Astronomical sciences
classificationCode: 5109
subject: Space sciences

description: We report on the discovery of four millisecond pulsars (MSPs) in the High Time Resolution Universe (HTRU) pulsar survey being conducted at the Parkes 64-m radio telescope. All four MSPs are in binary systems and are likely to have white dwarf companions. In addition, we present updated timing solutions for 12 previously published HTRU MSPs, revealing new observational parameters such as five proper motion measurements and significant temporal dispersion measure variations in PSR J1017−7156.We discuss the case of PSR J1801−3210, which shows no significant period derivative ( ˙P ) after four years of timing data. Our bestfit solution shows a ˙P of the order of 10−23, an extremely small number compared to that of a typical MSP. However, it is likely that the pulsar lies beyond the Galactic Centre, and an unremarkable intrinsic ˙P is reduced to close to zero by the Galactic potential acceleration. Furthermore,we highlight the potential to employ PSR J1801−3210 in the strong equivalence principle test due to its wide and circular orbit. In a broader comparison with the known MSP population, we suggest a correlation between higher mass functions and the presence of eclipses in ‘very low-mass binary pulsars', implying that eclipses are observed in systems with high orbital inclinations.We also suggest that the distribution of the total mass of binary systems is inversely-related to the Galactic height distribution. Finally, we report on the first detection of PSRs J1543−5149 and J1811−2404 as gamma-ray pulsars.
Methods for Improving the Ease of Use of Hearing Aids
Creators: name: Miegel, Jonathon
Publisher: name: Swinburne
Year: 2024

description: This thesis explores two main avenues for improving the user experience of hearing aids. To address user concerns regarding ease of use and manipulability, a modular interface was designed and prototyped to facilitate a modular hearing aid. The design, development, and testing of an acoustic wireless communication system between a smartphone and a hearing aid is also presented. By leveraging the existing hardware and firmware on the hearing aid an always-on low power wireless receiver can be implemented to address user concerns regarding both battery life and ease of use.
The Canadian HIV and aging cohort study - determinants of increased risk of cardio-vascular diseases in HIV-infected individuals: rationale and study protocol
Creators: name: Durand, Madeleine
name: Chartrand-Lefebvre, Carl
name: Baril, Jean-Guy
name: Trottier, Sylvie
name: Trottier, Benoit
name: Harris, Marianne
name: Walmsley, Sharon
name: Conway, Brian
name: Wong, Alexander
name: Routy, Jean-Pierre
name: Kovacs, Colin
name: MacPherson, Paul A
name: Monteith, Kenneth M
name: Mansour, Samer
name: Thanassoulis, George
name: Abrahamowicz, Michal
name: Zhu, Zhitong
name: Tsoukas, Christos
name: Ancuta, Petronela
name: Bernard, Nicole
name: Tremblay, Cécile L
Publisher: name: BioMed Central
Year: 2017

description: Background: With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the infection. We hypothesized that the chronic and persistent inflammation and immune activation associated with HIV disease leads to accelerated aging, characterized by CVD. This will translate into higher incidence rates of CVD in HIV infected participants, when compared to HIV negative participants, after adjustment for traditional CVD risk factors. When characterized further using cardiovascular imaging, biomarkers, immunological and genetic profiles, CVD associated with HIV will show different characteristics compared to CVD in HIV-negative individuals. Methods/design: The Canadian HIV and Aging cohort is a prospective, controlled cohort study funded by the Canadian Institutes of Health Research. It will recruit patients living with HIV who are aged 40 years or older or have lived with HIV for 15 years or more. A control population, frequency matched for age, sex, and smoking status, will be recruited from the general population. Patients will attend study visits at baseline, year 1, 2, 5 and 8. At each study visit, data on complete medical and pharmaceutical history will be captured, along with anthropometric measures, a complete physical examination, routine blood tests and electrocardiogram. Consenting participants will also contribute blood samples to a research biobank. The primary outcome is incidence of a composite of: myocardial infarction, coronary revascularization, stroke, hospitalization for angina or congestive heart failure, revascularization or amputation for peripheral artery disease, or cardiovascular death. Preplanned secondary outcomes are all-cause mortality, incidence of the metabolic syndrome, incidence of type 2 diabetes, incidence of renal failure, incidence of abnormal bone mineral density and body fat distribution. Patients participating to the cohort will be eligible to be enrolled in four pre-planned sub-studies of cardiovascular imaging, glucose metabolism, immunological and genetic risk profile. Discussion: The Canadian HIV and Aging Cohort will provide insights on pathophysiological pathways leading to premature CVD for patients living with HIV.
3173779.pdf
Creators: name: Li, Lan
name: Lin, Hongtao
name: Huang, Yizhong
name: Shiue, Ren-Jye
name: Yadav, Anupama
name: Li, Junying
name: Michon, Jerome
name: Englund, Dirk
name: Richardson, Kathleen
name: Gu, Tian
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary Material
Photocurable Sealant Development for Hemostasis and Aortic Aneurysm Thrombus Characterization With Ultrasound, Histology, and Microscopy
Creators: name: Schepers, Luke
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 320101
subject: Cardiology (incl. cardiovascular diseases)
classificationCode: 329999
subject: Other biomedical and clinical sciences not elsewhere classified

description: Hemorrhage and aortic aneurysms result from external or internal damage to a vessel wall and can be lethal if timely interventions are not made. Blood clotting and thrombus sometimes have a negative connotation in the medical community, but the coagulation cascade is a vital response to hemorrhage and disease. For hemorrhage, the coagulation cascade forms a plug at the injury site providing potentially life-saving hemostasis. In aortic aneurysms, blood coagulates inside the vessel or vessel wall to form intraluminal or intramural thrombus. The role of intraluminal and intramural thrombus in aneurysm rupture remains poorly understood, but past research suggests it may protect against further vessel damage dependent on its location and time of deposition. My dissertation focuses on application of a new photocurable sealant that surrounds a wound and aids in the coagulation cascade during hemorrhage, and analysis of the intramural and intraluminal thrombus that forms in aortic dissections and abdominal aortic aneurysms, respectively. We used volumetric and pulsed-wave Doppler ultrasound to detect changes in hemodynamics, vessel morphology, aneurysm thrombus deposition, and tracked the photocurable sealant’s performance and degradation in vivo. We used novel scanning electron microscopy analysis techniques in aortic aneurysm studies to uncover and quantify new information about thrombus structure. Our characterization and in vivo feasibility study with the photocurable sealant can serve as evidence for translation to future use in humans, and our techniques and findings in murine aneurysm models can potentially be used to elucidate the role and structure of thrombus in human aortic aneurysms.
How SMEs Strive to Achieve Competitive Advantage with IT-Supported Business Processes: An Empirical Study
Creators: name: Schubert, Petra
name: Leimstoll, Uwe
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2008
Subjects: subject: B2B-Integration
subject: Business Software
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Results from a longitudinal empirical study on the use of information technology (IT) in Swiss small and medium-sized enterprises (SMEs) form the basis of this paper. In the recent survey, 917 questionnaires were collected and analysed. Selected findings are presented in ten conclusions which were drawn from the analysis of the responses. We see that the degree of information integration is very high in Swiss SMEs. Surprisingly, secondary process areas are better integrated across the company than primary process areas. The electronic exchange of data is quite common in SMEs and is performed, in many cases, at an international level. Swiss SMEs see the customer-oriented processes as important for their future competitiveness. On the other hand, they lay great importance on a well-working accounting process and the effective access to a management information system. Most SMEs embrace IT as a way to improve their business.
Make or buy? Die Strategie und nicht Ressourcenknappheit sollte entscheiden
Creators: name: Leimstoll, Uwe
Publisher: name: Netzmedien AG
Year: 2002
Subjects: subject: E-Business
subject: Knowledge Management
subject: Management
subject: Strategie
subject: Wissensmanagement
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Outsourcing und Kompetenzentwicklung bedingen sich gegenseitig. Der Beitrag beschreibt diese Interdependenzen speziell für den Bereich des IT- und E-Business-Managements. Auf der Grundlage der Transaktionskostenökonomik wird ein einfaches Entscheidungsmodell entwickelt, welches die Wahl der richtigen Sourcing-Strategie erleichtert. In der langen Frist bestimmt die gewählte Strategie, welche Kompetenzen im eigenen Unternehmen zu entwickeln sind. Den Netzguide IT-Economics & Managed Services könnnen Sie zum Preis von CHF 58.- direkt bei der Netzmedien AG bestellen (ISBN 3-907096-00-2).
Mit Kundendaten mehr Nutzen erzeugen
Creators: name: Leimstoll, Uwe
name: Okonek, Christiane C.
Publisher: name: Hanser
Year: 2008
Subjects: subject: Business Software
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Kundendaten sind eine wichtige Wissensquelle für Marketing und Kommunikation. Besonders wertvoll sind Daten, die einer bestimmten Person zugeordnet werden können. Sie bilden das "Kundenprofil". Auf der Basis von Kundenprofilen lassen sich viele Marketing- und Kommunikationsmassnahmen sowie auch die Interaktion mit dem Kunden im E-Commerce individueller gestalten. Die Anpassung der Kommunikation an die individuellen Bedürfnisse eines Kunden wird als "Personalisierung" bezeichnet. Dieser Beitrag zeigt an zwei unterschiedlichen Beispielen, wie Kundenprofile systematisch aufgebaut, analysiert und für die personalisierte Kommunikation genutzt werden können.
Towards purely constructive machine learning
Creators: name: Walker, Ian
Publisher: name: Imperial College London
Year: 2023

description: Machine learning has evolved from more traditional statistical approaches and is able to tackle problems that were previously impossible to solve. However, we lack a proper understanding of why and how these new highly expressive models work, which leads to difficulties in applying them as effectively as could be done. In this thesis, I show that properly modelling the constraints inherent in a particular application domain can lead to better performance with a terser, simpler model (chapter 2), and that even a complicated model cannot learn when the data input into the model is uninformative (chapter 3). Based on this work, I build a case to generalise methods for designing models and drawing inferences by applying a constructivist approach grounded in category theory and functional programming.
Informatikausbildung in der Schweiz: Wir müssen dranbleiben!
Creators: name: Dettling, Walter
Publisher: name: Netzmedien
Year: 2013
Subjects: subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Seit mehr als 20 Jahren hören wir, dass die Schweiz viel zu wenige Informatiker ausbildet. Aktuell droht über 2000 Informatikern bei der UBS die Kündigung. Haben wir nun zu viele oder zu wenige Informatiker? Oder vielleicht nicht die richtigen?
A Hadtudományi Lexikon új kötetéről
Creators: name: Gőcze, István
name: Krajnc, Zoltán
name: Padányi, József
Publisher: name: Magyar Hadtudományi Társaság
Year: 2020

description: Hadtudomány, vol. 30. issue 1., ISSN 1215-4121, eISSN 1588-0605
Mechanism of partial agonism in AMPA-type glutamate receptors
Creators: name: Salazar, Hector
name: Eibl, Clarissa
name: Chebli, Miriam
name: Plested, Andrew
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Ion channels in the nervous system
subject: Ion transport
subject: X-ray crystallography
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly—partial agonists—also exist. Whether these partial agonists have weak activity because they stabilize less active forms, sustain active states for a lesser fraction of the time or both, remains an open question. Here we describe the crystal structure of an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) ligand binding domain (LBD) tetramer in complex with the partial agonist 5-fluorowillardiine (FW). We validate this structure, and others of different geometry, using engineered intersubunit bridges. We establish an inverse relation between the efficacy of an agonist and its promiscuity to drive the LBD layer into different conformations. These results suggest that partial agonists of the AMPAR are weak activators of the receptor because they stabilize multiple non-conducting conformations, indicating that agonism is a function of both the space and time domains.
Achieving high performance content streaming with adaptive chunklets and active queue management
Creators: name: Kua, Jonathan
Publisher: name: Swinburne
Year: 2024

description: Recent years have seen a rapid increase in the volume of video/content streaming traffic on the Internet. The demand for a better user experience has also concurrently increased, with viewers preferring quicker video startup, higher video quality, and fewer rebuffers. Consumer video streams are likely to be bottlenecked and impacted by emerging Active Queue Management (AQM) schemes. This thesis spans the entire breadth from an in-depth review of content streaming and AQM technologies to a proposal/validation of a novel and backward-compatible technique for improving streaming performance. This thesis is firmly rooted in the reality of today's Internet technology and represents a thoroughly practical study with a potential for immediate impact.
Nerve cell differentiation using scaffold-based cell culture in bioreactors with electrical stimulation
Creators: name: Grossemy, Simon
Publisher: name: Swinburne
Year: 2024

description: Nerve injuries or neural diseases are a major issue in the world. With such conditions, neural function may or may not return and can lead to various types of permanent disability. Efforts to cure or treat these injuries or diseases have met with many difficulties such as crossing the blood-brain barrier using drugs or the site of cell transplantation being an inhospitable environment for nerve regeneration. The reasons for these problems are diverse and not fully understood, making it difficult to develop treatments to overcome the current shortcomings. A better understanding of neural cell responses to their surrounding environment and the conditions which can lead them to differentiation are key information needed to cure affected patients. This work demonstrates that substantial benefits in terms of cell growth and neural differentiation can be obtained using a complex cell culture environment combining suitable protein coatings, 3D scaffolds, electrical stimulation with non-conductive scaffolds, and bioreactor systems with dynamic flow of culture medium.
3179282.pdf
Creators: name: Garcia, Missael
name: Edmiston, Christopher
name: York, Timothy
name: Marinov, Radoslav
name: Mondal, Suman
name: Zhu, Nan
name: Sudlow, Gail
name: Akers, Walter
name: Margenthaler, Julie
name: Achilefu, Samuel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document provides supplementary information to “A bio-inspired imager improves sensitivity for near-infrared fluorescence image-guided surgery,” DOI. Figures for the imaging sensor block and timing diagram and the microfabrication procedure for
Understanding galaxies and their gas
Creators: name: Pointon, Stephanie Kate
Publisher: name: Swinburne
Year: 2024

description: The circumgalactic medium is a vast halo of gas surrounding galaxies comprised of accreting gas from the intergalactic medium, outflows from stellar winds and recycled gas. Understanding how these gas flows enter and exit galaxies is key to our understanding of galaxy evolution. We have found that the metal content of accreting or outflowing gas is similar, suggesting that metallicity is not a useful tracer of accretion. We have also investigated group environments and found that there is less highly ionized gas and its kinematically narrower than isolated environments. Furthermore, the metallicity of group environments is similar to isolated environments.
3179282.pdf
Creators: name: Garcia, Missael
name: Edmiston, Christopher
name: York, Timothy
name: Marinov, Radoslav
name: Mondal, Suman
name: Zhu, Nan
name: Sudlow, Gail
name: Akers, Walter
name: Margenthaler, Julie
name: Achilefu, Samuel
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: This document provides supplementary information to “A bio-inspired imager improves sensitivity for near-infrared fluorescence image-guided surgery,” DOI. Figures for the imaging sensor block and timing diagram and the microfabrication procedure for
Additional file 6 of Identification of a novel ERF gene, TaERF8, associated with plant height and yield in wheat
Creators: name: Zhang, Lei
name: Liu, Pan
name: Wu, Jing
name: Linyi Qiao
name: Guangyao Zhao
name: Jizeng Jia
name: Lifeng Gao
name: Jianming Wang
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 6: Table S4. Summary of agronomical traits of sample set 1 in nine environments.
Business Software Integration: An Empirical Study in Swiss SMEs
Creators: name: Schubert, Petra
name: Leimstoll, Uwe
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2005
Subjects: subject: Business Software
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: The integration of information systems is a topic which has long been discussed in the literature. Due to technological development, the possibilities for integration have considerably improved in recent years. The following paper concentrates on the integration of business software in SMEs and presents empirical primary data of the current situation in Switzerland. The study aims to demonstrate what has been experienced in previous integration projects and what the demands upon future business software solutions will be. The findings show that, in some software modules, the intensity of use and the degree of integration is dependent on the size of the company.
Dark-ages reionization and galaxy formation simulation – XVII. Sizes, angular momenta, and morphologies of high-redshift galaxies
Creators: name: Marshall, Madeline A.
name: Mutch, Simon J.
name: Qin, Yuxiang
name: Poole, Gregory B.
name: Wyithe, J. Stuart B.
Publisher: name: Swinburne
Year: 2024

description: We study the sizes, angular momenta, and morphologies of high-redshift galaxies, using an update of the MERAXES semi-analytic galaxy evolution model. Our model successfully reproduces a range of observations from redshifts z = 0-10. We find that the effective radius of a galaxy disc scales with ultraviolet (UV) luminosity as R-e proportional to L-UV(0.33) at z = 5-10, and with stellar mass as R-e proportional to M-*(0.24) at z = 5 but with a slope that increases at higher redshifts. Our model predicts that the median galaxy size scales with redshift as R-e proportional to (1 + z)(-m), where m = 1.98 +/- 0.07 for galaxies with (0.3-1)L-z=3* and m = 2.15 +/- 0.05 for galaxies with (0.12-0.3)L-z=3*. We find that the ratio between stellar and halo specific angular momentum is typically less than 1 and decreases with halo and stellar mass. This relation shows no redshift dependence, while the relation between specific angular momentum and stellar mass decreases by similar to 0.5 dex from z = 7 to z = 2. Our model reproduces the distribution of local galaxy morphologies, with bulges formed predominantly through galaxy mergers for low-mass galaxies, disc-instabilities for galaxies with M-* similar or equal to 10(10)-10(11.5)M(circle dot), and major mergers for the most massive galaxies. At high redshifts, we find galaxy morphologies that are predominantly bulge-dominated.
Food parenting practices for 5 to 12 year old children: a concept map analysis of parenting and nutrition experts input
Creators: name: O’Connor, Teresia M.
name: Mâsse, Louise C.
name: Tu, Andrew W.
name: Watts, Allison W.
name: Hughes, Sheryl O.
name: Beauchamp, Mark R. (Mark Robert), 1972-
name: Baranowski, Tom
name: Pham, Truc
name: Berge, Jerica M.
name: Fiese, Barbara
name: Golley, Rebecca
name: Hingle, Melanie
name: Kremers, Stef P. J.
name: Rhee, Kyung E.
name: Skouteris, Helen
name: Vaughn, Amber
Publisher: name: BioMed Central
Year: 2017

description: Background: Parents are an important influence on children’s dietary intake and eating behaviors. However, the lack of a conceptual framework and inconsistent assessment of food parenting practices limits our understanding of which food parenting practices are most influential on children. The aim of this study was to develop a food parenting practice conceptual framework using systematic approaches of literature reviews and expert input. Method: A previously completed systematic review of food parenting practice instruments and a qualitative study of parents informed the development of a food parenting practice item bank consisting of 3632 food parenting practice items. The original item bank was further reduced to 110 key food parenting concepts using binning and winnowing techniques. A panel of 32 experts in parenting and nutrition were invited to sort the food parenting practice concepts into categories that reflected their perceptions of a food parenting practice conceptual framework. Multi-dimensional scaling produced a point map of the sorted concepts and hierarchical cluster analysis identified potential solutions. Subjective modifications were used to identify two potential solutions, with additional feedback from the expert panel requested. Results: The experts came from 8 countries and 25 participated in the sorting and 23 provided additional feedback. A parsimonious and a comprehensive concept map were developed based on the clustering of the food parenting practice constructs. The parsimonious concept map contained 7 constructs, while the comprehensive concept map contained 17 constructs and was informed by a previously published content map for food parenting practices. Most of the experts (52%) preferred the comprehensive concept map, while 35% preferred to present both solutions. Conclusion: The comprehensive food parenting practice conceptual map will provide the basis for developing a calibrated Item Response Modeling (IRM) item bank that can be used with computerized adaptive testing. Such an item bank will allow for more consistency in measuring food parenting practices across studies to better assess the impact of food parenting practices on child outcomes and the effect of interventions that target parents as agents of change.
Der blogfreie Sonntag
Creators: name: Nierle, Julia
name: Bendel, Oliver
Publisher: name: Swiss Professional Media
Year: 2010
Subjects: subject: Informatik
subject: Internet
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Wer die Effektivität seiner Werbemassnahmen oder Unternehmenskommunikation steigern will, scheint am Web 2.0 nicht mehr vorbeizukommen. Herr und Frau Schweizer haben das Bloggen und Twittern auch im Privaten längst für sich entdeckt. Worüber sich kaum jemand den Kopf zerbricht: Die Ökobilanz der sozialen Dienste ist mehr als zweifelhaft.
Response to ETH Zurich's clarifications report - Call for transparency, accountability, and reform
Creators: name: Members of GEE
Publisher: name: Zenodo
Year: 2025

description: Following the publication of ETH Zurich’s "Clarifications Report" dated 25 April 2025, we, concerned members of the Crowther Lab, write to express our deep concern over the conclusions, methodology, and reasoning presented therein. While the report was intended to offer closure, it instead highlights profound procedural flaws and biased reasoning that pose long-term risks for both academic freedom and institutional trust.
Modulation of Elementary Calcium Release Mediates a Transition from Puffs to Waves in an IP3R Cluster Model
Creators: name: Rückl, Martin
name: Parker, Ian
name: Marchant, Jonathan S.
name: Nagaiah, Chamakuri
name: Johenning, Friedrich W.
name: Rüdiger, Sten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 500 Naturwissenschaften und Mathematik

description: The oscillating concentration of intracellular calcium is one of the most important examples for collective dynamics in cell biology. Localized releases of calcium through clusters of inositol 1,4,5-trisphosphate receptor channels constitute elementary signals called calcium puffs. Coupling by diffusing calcium leads to global releases and waves, but the exact mechanism of inter- cluster coupling and triggering of waves is unknown. To elucidate the relation of puffs and waves, we here model a cluster of IP3R channels using a gating scheme with variable non-equilibrium IP3 binding. Hybrid stochastic and deterministic simulations show that puffs are not stereotyped events of constant duration but are sensitive to stimulation strength and residual calcium. For increasing IP3 concentration, the release events become modulated at a timescale of minutes, with repetitive wave-like releases interspersed with several puffs. This modulation is consistent with experimental observations we present, including refractoriness and increase of puff frequency during the inter-wave interval. Our results suggest that waves are established by a random but time-modulated appearance of sustained release events, which have a high potential to trigger and synchronize activity throughout the cell.
The role of permanent Carbon Dioxide Removal in the power sector
Creators: name: Prado, Augustin
Publisher: name: Imperial College London
Year: 2023

description: In light of the current climate crisis context, utmost effort should be directed towards climate mitigation activities. Amongst them, the sustainable and cost-effective deployment of Carbon Dioxide Removal (CDR) solutions is integral to meeting global climate goals. As some CDR will have direct interaction with power, either by consuming or by producing it, it is imperative to measure the different impacts that CDR operations may have on the energy, and more specifically, the power system. Additionally, the fervour surrounding carbon removal frequently disregards one of its most significant facets: its permanence. Because of the long life of carbon dioxide (CO2) in the atmosphere, politics, with the help of the scientific community, needs to incorporate the long-term effects of CO2 emissions in today’s decisions. Equivalently, fungibility between removals and emissions must be carefully monitored. In this thesis, we propose a framework for co-optimizing the power and CDR sectors, using the UK as a case study. We identify techno-economically and biogeophysically feasible pathways to meeting the net zero targets through the deployment of a range of CDR methods. We find that biomass availability is crucial to meet national targets, through the deployment of BECCS and biochar. When biomass is abundant, BECCS plays a significant role in achieving net zero targets, and natural gas with CCS and intermittent renewables are less important. Furthermore, we propose a climate repair value metric to assess the permanent cost of each CDR solution. Through this metric, geological storage demonstrates significantly greater permanence when compared to less secure CDR methods, such as biochar or afforestation. This thesis aims to convey clear messages to policymakers and corporations operating in the CDR or energy sector by offering valuable insights into the implementation of a permanent CDR portfolio to achieve climate commitments and their implications in the national power mix.
EFFECTS OF DIGITAL MARKETING ON INTERNATIONAL MARKET GROWTH
Creators: name: Hanifeh Manafzadeh, Zolaykha Manafzadeh
Publisher: name: TuEngr Group
Year: 2019
Subjects: E-marketing
International export market growth
Business network relationships
Digital marketing
Marketing ability.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 13, 10A13G: 1-9
การกำกับดูแลการเผยแพร่เนื้อหาผ่านสื่อออนไลน์ของนักข่าวพลเมือง
Creators: name: อภิญญ์พัทร์ กุสิยารังสิทธิ์
Publisher: name: มหาวิทยาลัยเทคโนโลยีราชมงคลพระนคร
Year: 2019
Subjects: นักข่าวพลเมือง
การกระทำความผิดในสื่อออนไลน์
เนื้อหาสื่อออนไลน์

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขามนุษยศาสตร์และสังคมศาสตร์, 4, 1, 87-101
Improvement of recycled concrete aggregate using polyvinyl alcohol for pavement applications
Creators: name: Yaowarat, Teerasak
Publisher: name: Swinburne
Year: 2024

description: This thesis is to study the possibility of Recycled Concrete Aggregate (RCA) modified by Polyvinyl Alcohol (PVA) and Fly Ash (FA) for using in pavement applications. Utilities of RCA reduce both waste concrete from demolition and the devastating of natural aggregate sources effectively. But, certain limitations such as low crushing strength and low abrasion resistance makes the flexural strength properties of RCA concrete and RCA base/subbase lower than the material makes from Natural Aggregate. However, the flexural strength of RCA can be improve by using PVA and FA. Therefore, the use of RCA together with PVA and FA in road engineering applications is useful in term of engineering and economic and environmental perspectives.
The Eulerian Bratteli Diagram and Traces on Its Associated Dimension Group
Creators: name: Felisberto Valente, Gustavo
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Bratteli diagrams
C*-algebras

description: In this thesis we present two important closely related examples of Bratteli diagrams: the Pascal triangle and the Eulerian Bratteli diagram. The former is well-known and related to binomial coefficients. The latter, which is the main object of the thesis, is related to the Eulerian numbers. Bratteli diagrams were introduced in 1972 by Ola Bratteli in his study of approximately finite dimensional (AF) C*-algebras. In 1976, George Arthur Elliott associated to an AF C*-algebra or to a corresponding Bratteli diagram an ordered group, he called dimension group. In the first part of the thesis we study the space of infinite paths of the Eulerian diagram, and we realize it as a projective limit of finite permutation groups. In the second part, we study the state space of the dimension group associated to the Eulerian Bratteli diagram. It is a compact convex set and we describe its extremal points. Finally, we use this description to give a necessary and sufficient condition for an element of this dimension group to be positive.
The Extended Web Assessment Method (EWAM) applied: do websites for consumer goods stand the test?
Creators: name: Schubert, Petra
name: Leimstoll, Uwe
Publisher: name: International Institute of Infonomics
Year: 2001
Subjects: subject: E-Commerce
subject: Electronic Markets
subject: Internet
subject: New Markets
subject: Web Assessment
subject: Website
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: The paper presents an analysis of four commercial Web sites in the consumer goods sectors. The Web sites were evaluated using the Extended Web Assessment Method (EWAM), an evaluation tool which has been specifically created for the assessment of e-commerce applications. EWAM builds on the Web Assessment Method developed at the University of St. Gallen, Switzerland [Schubert/Selz, 1999] and integrates findings from the Technology Acceptance Model [Davis, 1985] and several alternative approaches. It defines an evaluation grid including a set of criteria to appraise the quality and success of existing e-commerce applications. The focus lies on consumer perspectives and the specific features of the Internet as medium. The findings show that most Web sites are far from fully meeting user expectations. The paper presents the findings of an empirical study carried out in April 2001. Twenty students from an executive training class in E-Business completed the web assessment forms.
An immediate–late gene expression module decodes ERK signal duration
Creators: name: Uhlitz, Florian
name: Sieber, Anja
name: Wyler, Emanuel
name: Fritsche-Guenther, Raphaela
name: Meisig, Johannes
name: Landthaler, Markus
name: Klinger, Bertram
name: Bluethgen, Nils
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The RAF‐MEK‐ERK signalling pathway controls fundamental, often opposing cellular processes such as proliferation and apoptosis. Signal duration has been identified to play a decisive role in these cell fate decisions. However, it remains unclear how the different early and late responding gene expression modules can discriminate short and long signals. We obtained both protein phosphorylation and gene expression time course data from HEK293 cells carrying an inducible construct of the proto‐oncogene RAF. By mathematical modelling, we identified a new gene expression module of immediate–late genes (ILGs) distinct in gene expression dynamics and function. We find that mRNA longevity enables these ILGs to respond late and thus translate ERK signal duration into response amplitude. Despite their late response, their GC‐rich promoter structure suggested and metabolic labelling with 4SU confirmed that transcription of ILGs is induced immediately. A comparative analysis shows that the principle of duration decoding is conserved in PC12 cells and MCF7 cells, two paradigm cell systems for ERK signal duration. Altogether, our findings suggest that ILGs function as a gene expression module to decode ERK signal duration.