cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
UnderstandinghowtheMiddle-6598.pdf
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 130202 Curriculum and Pedagogy Theory and Development
subject: FOS: Educational sciences

description: The following research papers discuss how the Middle Years Programme (MYP) focusses with a strong emphasis on collaboration within the various Expressive Arts Departments including Music, Drama, Art, and Visual Arts and how these are used to conceptualize the learning for students through being natural inquiries within the Baccalaureate programme. How the International Baccalaureate programme is structured with reference to the Middle Years Programme and what provisions should be catered for and adhered to in terms of assessments and the four criteria’s, which evaluated twice per year for Knowing, Understanding, Developing Skills, Thinking Creatively and Responding. Concluding that most educators have to incorporate stimulating and interesting lessons for students to follow and conclude their personal projects, which could be a composition, a performance to the wider audience and community through public performances. They can also annotate their work in their project journals and show their progress and understanding over a period of time. Thinking independently and developing these skills contributes to the students emotional and academic needs, which allows them to flourish into responsible life-long learners, understanding how to respond to their own ideas, questions and allowing them to see the bigger picture within a global context. The conclusion that the Middle Years Programme, especially within the Creative Arts Departments, allows students to progress and conclude their International Baccalaureate Programme and encompasses inquiry-based learning. The purpose of these aims is to allow each individual student to flourish and expand their understanding of the importance of Arts programme and how it relates within a Global context whether creating music, performing a drama play or being a genuine human being through exploring their creative talents and expressing themselves.
High Uptake of Systematic HIV Counseling and Testing and TB Symptom Screening at a Primary Care Clinic in South Africa
Creators: name: Hanrahan, Colleen
name: Sanne, Ian
name: Van Rie, Annelies
name: Bassett, Jean
name: Selibas, Katerina
name: Williams, Sharon
name: Kim, Peter
name: Clouse, Kate
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundTimely diagnosis and treatment of tuberculosis (TB) and HIV is important to reduce morbidity and mortality, and break the cycle of ongoing transmission.MethodsWe performed an implementation research study to develop a model for systematic TB symptom screening and HIV counseling and testing (HCT) for all adult clients at a primary care clinic and prospectively evaluate the 6-month coverage and yield, and 18-month sustainability at a primary care clinic in Johannesburg, South Africa.ResultsDuring the first 6 months, 26,515 visits occurred among 12,078 adults. The proportion of adults aware of their HIV status was 43.7% at the start of the first visit, increased to 84.6% at the end of the first visit, and to 90% at end of any visit during the first 6 months. During these 6 months, 1042 clients were newly diagnosed with HIV. HIV prevalence was 22.9% among those newly tested, and 58.9% among all adult clinic clients. High coverage of systematic HCT was sustained across all 18 months. Coverage of systematic HIV-stratified TB symptom screening during first 6-months was also high (89.6%) but only 35.0% of those symptomatic were screened by sputum. During these 6-months, 90 clients had a positive Xpert MTB/RIF assay, corresponding to a TB prevalence of 0.4% among all 23,534 clients TB symptom-screened and 2.8% among the 3,284 clients with a positive TB symptom screen. The initial high coverage of TB symptom screening was not sustained, with coverage of TB symptom screening dropping after the first six months to 70% and assessment by sputum dropping to 15%.ConclusionRoutine, systematic HCT and HIV-stratified TB symptom screening is feasible at primary care level. Systematic HCT doubled the proportion of clients with known HIV status. While HCT was sustainable, coverage of systematic TB screening dropped significantly after the first 6 months of implementation.
Engineering near infrared single photon emitters in ultrapure silicon carbide
Creators: name: Fuchs, F.
name: Stender, B.
name: Trupke, M.
name: Pflaum, J.
name: Dyakonov, V.
name: Astakhov, G. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Quantum emitters hosted in crystalline lattices are highly attractive candidates for quantum information processing, secure networks and nanosensing. For many of these applications it is necessary to have control over single emitters with long spin coherence times. Such single quantum systems have been realized using quantum dots, colour centres in diamond, dopants in nanostructures and molecules . More recently, ensemble emitters with spin dephasing times on the order of microseconds and room-temperature optically detectable magnetic resonance have been identified in silicon carbide (SiC), a compound being highly compatible to up-to-date semiconductor device technology. So far however, the engineering of such spin centres in SiC on single-emitter level has remained elusive. Here, we demonstrate the control of spin centre density in ultrapure SiC over 8 orders of magnitude, from below $10^{9}$ to above $10^{16} \,$cm$^{-3}$ using neutron irradiation. For a low irradiation dose, a fully photostable, room-temperature, near infrared (NIR) single photon emitter can clearly be isolated, demonstrating no bleaching even after $10^{14}$ excitation cycles. Based on their spectroscopic fingerprints, these centres are identified as silicon vacancies, which can potentially be used as qubits, spin sensors and maser amplifiers.
description: 5 pages, 4 figures
Ricostruzione ed esegesi di una tragedia frammentaria: il Fetonte di Euripide
Creators: name: Decembrini, Letizia
name: Montagner, Francesco
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: This article outlines the method used to reconstruct a 'script' of Euripides' Phaethon based on the preserved fragments.
description: Frammenti sulla Scena (online), N. 4 · 2023
HIV Associated Neurocognitive Disorders (HAND) in Malawian Adults and Effect on Adherence to Combination Anti-Retroviral Therapy: A Cross Sectional Study
Creators: name: Robertson, Kevin R.
name: Ngwalo, Chisomo
name: Solomon, Tom
name: Allain, Theresa J.
name: van Oosterhout, Joep J.
name: Stewart, Robert C.
name: Benjamin, Laura
name: Khoo, Saye
name: Kelly, Christine M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundLittle is known about the prevalence and burden of HIV associated neurocognitive disorder (HAND) among patients on combination antiretroviral therapy (cART) in sub-Saharan Africa. We estimated the prevalence of HAND in adult Malawians on cART and investigated the relationship between HAND and adherence to cART.MethodsHIV positive adults in Blantyre, Malawi underwent a full medical history, neurocognitive test battery, depression score, Karnofsky Performance Score and adherence assessment. The Frascati criteria were used to diagnose HAND and the Global Deficit Score (GDS) was also assessed. Blood was drawn for CD4 count and plasma nevirapine and efavirenz concentrations. HIV negative adults were recruited from the HIV testing clinic to provide normative scores for the neurocognitive battery.ResultsOne hundred and six HIV positive patients, with median (range) age 39 (18–71) years, 73% female and median (range) CD4 count 323.5 (68–1039) cells/µl were studied. Symptomatic neurocognitive impairment was present in 15% (12% mild neurocognitive disorder [MND], 3% HIV associated dementia [HAD]). A further 55% fulfilled Frascati criteria for asymptomatic neurocognitive impairment (ANI); however factors other than neurocognitive impairment could have confounded this estimate. Neither the symptomatic (MND and HAD) nor asymptomatic (ANI) forms of HAND were associated with subtherapeutic nevirapine/efavirenz concentrations, adjusted odds ratio 1.44 (CI. 0.234, 8.798; p = 0.696) and aOR 0.577 (CI. 0.09, 3.605; p = 0.556) respectively. All patients with subtherapeutic nevirapine/efavirenz levels had a GDS of less than 0.6, consistent with normal neurocognition.Discussion/ConclusionFifteen percent of adult Malawians on cART had a diagnosis of MND or HAD. Subtherapeutic drug concentrations were found exclusively in patients with normal neurocognitive function suggesting HAND did not affect cART adherence. Further study of HAND requires more robust locally derived normative neurocognitive values and determination of the clinical relevance of ANI.
Il ‘giuoco delle parti’ nel Fetonte di Euripide
Creators: name: Carpanelli, Francesco
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: This work contains annotations on what remains of Euripides’ Phaeton, especially finalized to the creation of a 'script' of this lost drama. The key points of the research to date and the proposals aimed at creating a text not only indispensable for integrating the Euripides’ corpus but also dedicated to an audience that would otherwise never close to it.
description: Frammenti sulla Scena (online), N. 4 · 2023
Untitled Item
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 190409 Musicology and Ethnomusicology
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper discusses the difference between Ethnomusicology and African Musicology with reference to the work of Professor Geoff Mapaya. The importance of culture and identity within music and the cultural differences one explore through music within a South African context with the views shared within a Western Perspective. The objective of this paper is to clearly underpin the two separate entities and to enlighten future researchers how to differentiate between the two, giving rise to a new era for music scholars to explore, research and elaborate. It is a discourse of African Musicology and Culture within a South African Context.
Collective oscillations in spatially modulated exciton-polariton condensate arrays
Creators: name: Tikhomirov, A. A.
name: Kanakov, O. I.
name: Altshuler, B. L.
name: Ivanchenko, M. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We study collective dynamics of interacting centers of exciton-polariton condensation in presence of spatial inhomogeneity, as modeled by diatomic active oscillator lattices. The mode formalism is developed and employed to derive existence and stability criteria of plane wave solutions. It is demonstrated that $k_0=0$ wave number mode with the binary elementary cell on a diatomic lattice possesses superior existence and stability properties. Decreasing net on-site losses (balance of dissipation and pumping) or conservative nonlinearity favors multistability of modes, while increasing frequency mismatch between adjacent oscillators detriments it. On the other hand, spatial inhomogeneity may recover stability of modes at high nonlinearities. Entering the region where all single-mode solutions are unstable we discover subsequent transitions between localized quasiperiodic, chaotic and global chaotic dynamics in the mode space, as nonlinearity increases. Importantly, the last transition evokes the loss of synchronization. These effects may determine lasing dynamics of interacting exciton-polariton condensation centers.
description: 9 pages, 3 figures
HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?
Creators: name: Morris, Bethany L.
name: Eron, Joseph
name: Losina, Elena
name: Freedberg, Kenneth A.
name: Kelly, Kathleen A.
name: Walensky, Rochelle P.
name: Sypek, Alexis
name: Weinstein, Milton C.
name: Paltiel, A. David
name: Berkowitz, Bethany K.
name: Seage, George R.
name: Sax, Paul E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundWe examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART).MethodsWe used a computer simulation model to assess three HIV cure strategies: Gene Therapy, Chemotherapy, and Stem Cell Transplantation (SCT), each compared to ART. Efficacy and cost parameters were varied widely in sensitivity analysis. Outcomes included quality-adjusted life expectancy, lifetime cost, and cost-effectiveness in dollars/quality-adjusted life year ($/QALY) gained. Strategies were deemed cost-effective with incremental cost-effectiveness ratios <$100,000/QALY.ResultsFor patients on ART, discounted quality-adjusted life expectancy was 16.4 years and lifetime costs were $591,400. Gene Therapy was cost-effective with efficacy of 10%, relapse rate 0.5%/month, and cost $54,000. Chemotherapy was cost-effective with efficacy of 88%, relapse rate 0.5%/month, and cost $12,400/month for 24 months. At $150,000/procedure, SCT was cost-effective with efficacy of 79% and relapse rate 0.5%/month. Moderate efficacy increases and cost reductions made Gene Therapy cost-saving, but substantial efficacy/cost changes were needed to make Chemotherapy or SCT cost-saving.ConclusionsDepending on efficacy, relapse rate, and cost, cure strategies could be cost-effective compared to current ART and potentially cost-saving. These results may help provide performance targets for developing cure strategies for HIV.
Trionyx foveatus
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1860
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Testudines
Trionychidae
Trionyx
Trionyx foveatus

description: Trionyx foveatus. Among the fossils of Dr. Hayden’s Judith River Collection, there are a number of small fragments of costal and sternal plates, having much resemblance to the corresponding parts of our living soft-shelled Turtles, forming the genus Trionyx. The exterior surface of the fragments of costal plates, (figure 2, plate 11,) is impressed with shallow pits, except near the borders of the plates. The pits are smaller and rounded at the vertebral extremities of the latter, and become larger outwardly, assuming a polyhedral, often oblong and reniform outline. The fragments of the sternal plates, (figure 1, plate 11,) have their exterior surface covered with short vermicular ridges, which recall a remote appearance to Arabic letters. One of the fragments of a costal plate, apparently the third or fourth, represented in figure 2, is almost 11 lines wide, and 2 lines thick. Two fragments of a hyposternal plate, (figure 1,) are 3 lines in thickness. In association with the remains of several other genera of Turtles, and of some other animals in the Great Lignite Tertiary Basin, near Long Lake, below Fort Clark, Nebraska, Dr. Hayden obtained small fragments of the carapace or osseous shell of a Turtle, not distinguishable from those referred to, Trionyx foveatus. The specimens are too imperfect positively to determine whether they actually belong to the same species. Fragments of a last costal plate, represented in figure 3, plate 11, measures 4 lines in thickness, and are closely foveated on the exterior surface, in the manner described in the account of the corresponding plates of Trionyx foveatus from the Judith River Explanation of Figures, Plate 11. . Figures 1—3. Fragments of the carapace and sternum of Trionyx foveatus, of the natural size. Figure 1. Two fragments of a hyposternal plate; an ideal outline given in the restored condition. Figure 2. Fragment of a left costal plate. Figure 3. Fragment of the last right costal plate, supposed to belong to the same species as the preceding
description: Published as part of Leidy, J., 1860, Extinct vertebrata from the Judith River and Great Lignite formations of Nebraska., pp. 139-154 in Transactions of the American Philosophical Society 11 on pages 148-149, DOI: 10.5281/zenodo.1064078
New Galactic embedded clusters and candidates from a WISE Survey
Creators: name: Camargo, Denilso
name: Bica, Eduardo
name: Bonatto, Charles
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We carried out a search for new infrared star clusters, stellar groups and candidates using WISE images, which are very sensitive to dust emission nebulae. We report the discovery of 437 embedded clusters and stellar groups that show a variety of structures, both in the stellar and nebular components. Pairs or small groupings of clusters are observed, suggesting multiple generations at the early formation stages. The resulting catalogue provides Galactic and equatorial coordinates, together with angular sizes for all objects. The nature of a representative test sub-sample of 14 clusters is investigated in detail by means of 2MASS photometry. The colour magnitude diagrams and radial density distributions characterize them as stellar clusters. The 437 new objects were found in the ranges $145^\circ\,\leq\,\ell\,\leq 290^\circ$ and $-25^\circ\,\leq\,b\,\leq 20^\circ$, and they appear to be a major object source for future studies of star cluster formation and their early evolution. WISE is a powerful tool to further probe for very young clusters throughout the disk.
description: 21 pages, 13 figures
HIV Prevalence and Incidence in a Cohort of Women at Higher Risk for HIV Acquisition in Chókwè, Southern Mozambique
Creators: name: Feldblum, Paul J.
name: Thompson, Ricardo
name: Enosse, Sónia
name: Banze, Reginaldo
name: Robb, Merlin L.
name: Cunaca, Joana
name: Arnaldo, Paulo
name: Nhanala, Aristides
name: Dubé, Karine
name: Chen, Pai-Lien
name: Muluana, Chadreque
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundReliable HIV incidence estimates for Mozambique are limited. We conducted a prospective HIV incidence study as part of a clinical research site development initiative in Chókwè district, Gaza Province, southern Mozambique.MethodsBetween June 2010 and October 2012, we recruited women at sites where women at higher risk of HIV infection would likely be found. We enrolled and tested 1,429 sexually active women in the screening phase and 479 uninfected women in the prospective phase. Participants were scheduled for 12+ months follow-up, when they underwent face-to-face interviews, HIV counseling and testing, and pregnancy testing. We observed a total of 373.1 woman-years (WY) of follow-up, with mean (median) of 9.4 (9.7) women-months per participant.ResultsThe prevalence of HIV was 29.4% (95% confidence interval [CI]: 27.0–31.8%). In multivariable logistic regression analysis, factors that remained significantly associated with prevalent HIV were: older age (OR: 0.6; 95% CI: 0.4–0.7), lower educational level (OR: 0.4; 95% CI: 0.3–0.7), and using hormonal contraception (OR: 0.6; 95% CI: 0.4–0.7) or condoms (OR: 0.5; 95% CI: 0.3–0.7). We observed an HIV incidence rate of 4.6 per 100 WY (95% CI: 2.7, 7.3). The HIV incidence was 4.8 per 100 WY (95% CI: 2.5, 8.3) in women aged 18–24 years, 4.5 per 100 WY (95% CI: 1.2, 11.4) in women aged 25–29 years and 3.2 per 100 WY (95% CI: 0.1, 18.0) in the 30–35 years stratum. None of the demographic factors or time-varying behavioral factors examined was significantly associated with incident HIV infection in bivariable analysis at p≤0.10.ConclusionsWe found a high HIV incidence among sexually active young women in Chókwè, Mozambique. HIV prevention programs should be strengthened in the area, with more comprehensive reproductive health services, regular HIV testing, condom promotion, and messaging about multiple sexual partners.
The IPC-7533.pdf
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 190409 Musicology and Ethnomusicology
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 130202 Curriculum and Pedagogy Theory and Development
subject: FOS: Educational sciences

description: The following research paper will investigate the importance of the International Primary Years Curriculum (IPC) and the added benefits for schools to consider within an International School setting. The standard norm in most International Schools is to serve a community of students coming from around the globe with different cultural backgrounds, religious views or beliefs, and attitudes. It is important to teach learners the importance of tolerance and understanding with a focus on respect for people of other cultures. The music curriculum is diverse as you have certain assessment criteria’s that have to be met for each lesson. Understanding the Entry point, Knowledge of Harvest the Bigger Picture, Research, and Recording Activities and celebrating the success of learning and inquiry with the entry point is imperative. Educational systems are constantly evolving and fundamental to the IPC approach to learning is a clear progression in skill development. This even applies to the personal learning goals, which emphasize adaptability, resilience, cooperation, and respect and which, as a result of progressive skill development, help children to become able and inspired learners. International-mindedness is embedded in all IPC learning to ensure that children grow up with a very clear global understanding. No one can properly predict the nature of work that will be available for today's primary age children by the time he or she are adults. Many of the jobs they will have simply don't yet exist, especially in the fields of ICT, technology, and science. So the principle of the IPC is to focus on personal, academic and international learning that will prepare children, wherever they may live, for the world of tomorrow. The researcher explores this further with a specific case study from Mexico where teachers share their ideas and perceptions around IPC. The concluding results reveal the need for Fieldwork Education back in England to make provision for English as Additional Language (EAL) or English as a Second Language (ESL) and differentiating for them in the one hundred and thirty units that are readily available for teachers to download and use within International Schools. The overall impression by most international teachers agreed that IPC allowed learners to develop their critically and analytical skills and offered a variety of cross-curricular activities for learners to explore.
Μὰ τὴν Ἀλεμάκα: Types of Verbal Humour in the Mime of Charition (P.Oxy. 413r)
Creators: name: Kitsou, Stamatia
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: The Charition mime, preserved on the recto of the P.Oxy. 413, is of major importance to the history and evolution of the genre under the Roman Empire. This case unifies most of the strands of research regarding the genre under discussion in a coherent vision proving that through a masterful generic assimilation of a wide range of patterns and devices the mime becomes a work of self-standing merit. Many scholars have illustrated the mime’s rich literary substratum, the analogies it bears with a wide range of texts (epic, tragedy, ancient novel), its affinities to other theatrical forms (melodramma, vaudeville) and its linguistic merits; undoubtedly one of Charition’s more interesting and tantalizing elements consists in the imaginative and euphoric mixture of Greek and Indian languages. The aim of this paper is to elucidate several instances of the dramaturgical exploitation of both languages along with mimographer’s verbal inventions to reinforce the comic effect. Under this prism, the words porde, Psolichos, Kottos and Alemaka, amidst others, seem to keep a key role to the play regarding its overarching aim, the laughter and entertainment of the audience.
description: Frammenti sulla Scena (online), N. 4 · 2023
A discussion of the International-6359 (2).pdf
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 130202 Curriculum and Pedagogy Theory and Development
subject: FOS: Educational sciences

description: This research paper outlines the International Baccalaureate Programme (IB) focusing primarily on the Music Curriculum and the importance of assessment, the expectations and outcomes related to the course overall. It is important for teachers abroad to have an understanding of the associated benefits when teaching the programme within International Schools. The IB Music programme aims to develop inquiring, knowledgeable and caring young people, who help to create a better and more peaceful world through intercultural understanding and respect. Most educators need to have an understanding of the differences between Higher and Standard Level Music and what enables students to pass the course successfully. These opportunities allow students to the understand the elements of music theory, learn about the various structures within music, familiarize themselves with the different musical periods and listen to music of various genres. All of these attributes develop their aural awareness and ear training skills. Through orchestrating various parts for either solo or ensemble compositions students are creative realizing their potential and understanding of compositional techniques. In conclusion, the IB Music programme prepares students for University utilizing their analytical skills to research different types of music and teach them how to deal with deadlines iterating time management skills.
On testing violations of Bose and $CPT$ symmetries via Dalitz plots and Dalitz `prism'
Creators: name: Sahoo, Dibyakrupa
name: Sinha, Rahul
name: Deshpande, N. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Bose symmetry and $CPT$ symmetry are two very fundamental symmetries of Nature. However, the validity of these symmetries in diverse phenomena must be verified by experiments. We propose new techniques to probe these two fundamental symmetries in the realm of mesons by using the Dalitz plot of a few three-body meson decays. Since these symmetries are very fundamental in nature, their violations, if any, are expected to be extremely small. Hence observing their violations requires study of a huge data sample. In this context we introduce a new three-dimensional plot which we refer to as the Dalitz 'prism'. This provides an innovative means for acquiring the huge statistics required for such studies. Using the Dalitz plots and the Dalitz prisms we chart out the way to probe the violations of Bose and $CPT$ symmetries in a significant manner. Since mesons are unstable and composite particles, testing the validity of Bose symmetry and the $CPT$ symmetry in these cases are of paramount importance for fundamental physics.
description: 5 pages, 2 figures; previous version was not the latest draft, had many references missing
MIGNEX Case Study Brief TUR1 - Migration and development dynamics in Hopa, Turkey
Creators: name: Ensari, Pinar
name: Kavur, Nilay
name: Mazzilli, Caterina
Publisher: name: Peace Research Institute Oslo
Year: 2022

description: The opening of the Turkey-Georgia border has introduced economic opportunities through cross-border trade. Yet many young adults feel discouraged by limited opportunities, and increasingly aspire to migrate internally.

Key Takeaways

Much of Hopa’s economic development has been built on free trade and border crossings between Turkey and Georgia.

Despite wealth expansion and improved living standards, there have been limited development interventions in the area.

Young people and their parents increasingly recognise the professional and educational opportunities of internal out-migration.
HIV-1 RNA Levels and Antiretroviral Drug Resistance in Blood and Non-Blood Compartments from HIV-1–Infected Men and Women enrolled in AIDS Clinical Trials Group Study A5077
Creators: name: Cu-Uvin, Susan
name: D’Aquila, Richard
name: Frenkel, Lisa
name: Coombs, Robert
name: Bosch, Ronald J.
name: Fiscus, Susan
name: Katzenstein, David
name: Bettendorf, Daniel
name: Mann, Marita
name: Kantor, Rami
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundDetectable HIV-1 in body compartments can lead to transmission and antiretroviral resistance. Although sex differences in viral shedding have been demonstrated, mechanisms and magnitude are unclear. We compared RNA levels in blood, genital-secretions and saliva; and drug resistance in plasma and genital-secretions of men and women starting/changing antiretroviral therapy (ART) in the AIDS Clinical Trials Group (ACTG) 5077 study.MethodsBlood, saliva and genital-secretions (compartment fluids) were collected from HIV-infected adults (≥13 years) at 14 United-States sites, who were initiating or changing ART with plasma viral load (VL) ≥2,000 copies/mL. VL testing was performed on all compartment fluids and HIV resistance genotyping on plasma and genital-secretions. Spearman rank correlations were used to evaluate concordance and Fisher’s and McNemar’s exact tests to compare VL between sexes and among compartments.ResultsSamples were available for 143 subjects; 36% treated (23 men, 29 women) and 64% ‘untreated’ (40 men, 51 women). RNA detection was significantly more frequent in plasma (100%) than genital-secretions (57%) and saliva (64%) (P<0.001). A higher proportion of men had genital shedding versus women (78% versus 41%), and RNA detection was more frequent in saliva versus genital-secretions in women when adjusted for censoring at the limit of assay detection. Inter-compartment fluid VL concordance was low in both sexes. In 22 (13 men, 9 women) paired plasma-genital-secretion genotypes from treated subjects, most had detectable resistance in both plasma (77%) and genital-secretions (68%). Resistance discordance was observed between compartments in 14% of subjects.ConclusionsHIV shedding and drug resistance detection prior to initiation/change of ART in ACTG 5077 subjects differed among tissues and between sexes, making the gold standard blood-plasma compartment assessment not fully representative of HIV at other tissue sites. Mechanisms of potential sex-dependent tissue compartmentalization should be further characterized to aid in optimizing treatment and prevention of HIV transmission.Trial RegistrationClinicalTrials.gov NCT00007488
CFD Analysis of Spherical Capsule Flow in Horizontal Pipeline
Creators: name: FADIEL, Ali F Ali
Publisher: name: figshare
Year: 2023
Subjects: Manufacturing safety and quality
Numerical modelling and mechanical characterisation

description: a new study and there is relatively little research and study in this area. It was therefore, selected as the focus of this research. For the aims of this study, Computational Fluid Dynamics (CFD) was used. CFD is a useful tool for the analysis of pipe flow problems. Optimization and analysis of the capsule may be performed by problems such as FLUENT CFD packages.
Pre-asymptotic critical behavior and effective exponents in disordered metallic quantum ferromagnets
Creators: name: Kirkpatrick, T. R.
name: Belitz, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We determine the pre-asymptotic critical behavior at the quantum ferromagnetic transition in strongly disordered metals. We find that it is given by effective power laws, in contrast to the previously analyzed asymptotic critical behavior, which is valid only in an unobservably small region. The consequences for analyzing experiments are discussed, in particular ways to distinguish between critical behavior and Griffiths-phase effects.
description: 5 pp, 2 figs
Untitled Item
Creators: name: FADIEL, Ali F Ali
Publisher: name: figshare
Year: 2022
Subjects: Manufacturing safety and quality

description: a new study and there is relatively little research and study in this area. It was therefore, selected as the focus of this research. For the aims of this study, Computational Fluid Dynamics (CFD) was used. CFD is a useful tool for the analysis of pipe flow problems. Optimization and analysis of the capsule may be performed by problems such as FLUENT CFD packages.
Kaiser Family Foundation Poll: January 2018 Kaiser Health Tracking Poll
Creators: name: Kaiser Family Foundation
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Important issues for congressional candidates (8); Affordable Care Act (ACA) favorability (1); priorities for President Donald Trump (8); knowledge of ACA (2); health care legislation (1); Democrats/Republicans responsible for problems with current health care law (1); congressional spending (8); Medicaid (1); concerns about health insurance (6); open enrollment (2); collapse of health insurance marketplaces (1); foreign aid (2); U.S. involvement in world affairs (1); improving health care in developing countries (3); spending tax refund (2).
Human Cytomegalovirus Gene Expression in Long-Term Infected Glioma Stem Cells
Creators: name: Cobbs, Charles
name: Fiallos, Estefania
name: Judkins, Jonathon
name: Dittmer, Dirk
name: Soroceanu, Liliana
name: Prichard, Mark
name: Matlaf, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The most common adult primary brain tumor, glioblastoma (GBM), is characterized by fifteen months median patient survival and has no clear etiology. We and others have identified the presence of human cytomegalovirus (HCMV) gene products endogenously expressed in GBM tissue and primary cells, with a subset of viral genes being consistently expressed in most samples. Among these viral genes, several have important oncomodulatory properties, regulating tumor stemness, proliferation, immune evasion, invasion and angiogenesis. These findings lead us to hypothesize that a specific HCMV gene signature may be associated with GBM pathogenesis. To investigate this hypothesis, we used glioma cell lines and primary glioma stem-like cells (GSC) infected with clinical and laboratory HCMV strains and measured relative viral gene expression levels along several time points up to 15 weeks post-infection. While HCMV gene expression was detected in several infected glioma lines through week 5 post-infection, only HCMV-infected GSC expressed viral gene products 15 weeks post-infection. Efficiency of infection across time was higher in GSC compared to cell lines. Importantly, HCMV-infected GSC outlived their uninfected counterparts, and this extended survival was paralleled by increased tumorsphere frequency and upregulation of stemness regulators, such as SOX2, p-STAT3, and BMX (a novel HCMV target identified in this study). Interleukin 6 (IL-6) treatment significantly upregulated HCMV gene expression in long-term infected glioma cultures, suggesting that pro-inflammatory signaling in the tumor milieu may further augment HCMV gene expression and subsequent tumor progression driven by viral-induced cellular signaling. Together, our data support a critical role for long-term, low-level HCMV infection in promoting survival, stemness, and proliferation of GSC that could significantly contribute to GBM pathogenesis.
Anticancer and Antiretroviral Activities of Methanolic Extract from Theobroma cacao L Pod Husk: Focusing on the Ethyl Acetate Partition
Creators: name: Yahya, Mustanir
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30401 Biologically Active Molecules
subject: 39999 Chemical Sciences not elsewhere classified
subject: 30104 Immunological and Bioassay Methods
subject: 30405 Molecular Medicine
subject: FOS: Basic medicine

description: Master data for a submission entitled “Anticancer and Antiretroviral Activities of Methanolic Extract from Theobroma cacao L Pod Husk: Focusing on the Ethyl Acetate Partition” submitted to F1000 Research
Hypogammaglobulinemia in BLT Humanized Mice – An Animal Model of Primary Antibody Deficiency
Creators: name: Wahl, Angela
name: Nochi, Tomonori
name: Denton, Paul W.
name: Garcia, J. Victor
name: Martinez-Torres, Francisco
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Primary antibody deficiencies present clinically as reduced or absent plasma antibodies without another identified disorder that could explain the low immunoglobulin levels. Bone marrow-liver-thymus (BLT) humanized mice also exhibit primary antibody deficiency or hypogammaglobulinemia. Comprehensive characterization of B cell development and differentiation in BLT mice revealed other key parallels with primary immunodeficiency patients. We found that B cell ontogeny was normal in the bone marrow of BLT mice but observed an absence of switched memory B cells in the periphery. PC-KLH immunizations led to the presence of switched memory B cells in immunized BLT mice although plasma cells producing PC- or KLH- specific IgG were not detected in tissues. Overall, we have identified the following parallels between the humoral immune systems of primary antibody deficiency patients and those in BLT mice that make this in vivo model a robust and translational experimental platform for gaining a greater understanding of this heterogeneous array of humoral immunodeficiency disorders in humans: (i) hypogammaglobulinemia; (ii) normal B cell ontogeny in bone marrow; and (iii) poor antigen-specific IgG response to immunization. Furthermore, the development of strategies to overcome these humoral immune aberrations in BLT mice may in turn provide insights into the pathogenesis of some primary antibody deficiency patients which could lead to novel clinical interventions for improved humoral immune function.
Lepidotus occidentalis
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1860
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Lepisoteiformes
Semionotidae
Lepidotus
Lepidotus occidentalis

description: Lepidotus OCCIDENTALIS. The genus of ganoid fishes Lepidotus, appears to have come into existence during the Liassic period, to have extended through the Oolitic, Wealdean, and Cretaceous periods, and to have become extinct in the Eocene Tertiary period. As if to keep up the association, in the manner that Dr. Mantell found together in the Wealdean deposits the remains of Iguanodon, Megalosaurus, Crocodilus, and Lepidotus, Dr. Hayden discovered with the remains of Trachodon, Deinodon, and Crocodilus, a half dozen ganoid fish scales, which appear to belong to the genus Lepidotus. The specimens may indicate two species, but with equal probability they may appertain to a single one. Four of the scales, (as represented in figures 20, 21, plate 11,) are lozenge-shaped, with their root prolonged from one side in the direction of the longest diameter of the lozenge. Two of the scales, (as represented in figures 22, 23,) are square, with their root projecting from one of the longer sides. All the specimens are invested with thick, shining, enamelled substance; and one of the square scales exhibits on its free surface, parallel square lines of growth. The largest lozenge-like scale has the sides of its free or enamel surface about 4 lines long; and the smallest has two of the sides 3 lines long, the other sides 2 lines long. The larger square scale has its long sides 5 lines, and its short sides 3 1/2 lines. Explanation of Figures, Plate 11. Figures 20—23. Scales of Lepidotus occidentalis, of the natural size.
description: Published as part of Leidy, J., 1860, Extinct vertebrata from the Judith River and Great Lignite formations of Nebraska., pp. 139-154 in Transactions of the American Philosophical Society 11 on page 149, DOI: 10.5281/zenodo.1064078
Frammenti comici, tradizioni paremiografiche e… paradeigmata retorici? Nota a Philem. fr. 20 K./A. (Δακτύλιος) e a Diph. fr. 65 K./A. (Πήρα)
Creators: name: De Poli, Mattia
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: These two comic fragments correspond to a proverb. A new interpretation of them is possible, if we relate them to the explanation of the same proverb offered by Aristeides the paroemiographer. Demosthenes and Herondas, using a variant of it, suggest that this proverbial expression may have originated from a famous story in the Athenian schools of rhetoric.
description: Frammenti sulla Scena (online), N. 4 · 2023
The importance of integrating technology within the PYP programme – implementing innovations within International Schools
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2022
Subjects: subject: 130304 Educational Administration, Management and Leadership
subject: FOS: Educational sciences

description: Using technology within our classrooms to promote 21st century learning has been an expectation for most teachers. For those originally from South Africa are now teaching abroad it is expected that every individual should be familiar with the International Baccalaureate (IB) Primary Years Programme (PYP), that is the norm. Focusing on the Music curriculum it is important to understand the PYP programme and how to make provisions for those using technology to enhance their compositional skills as part of the responding module of PYP. The following research paper discusses the PYP programme focusing on the Arts and how to implement Garage Band into your music curriculum creating opportunities for students to engage, share, be creative and compose music, which is the emphasis of the IB curriculum. Students have to become natural inquirers and through guiding them to complete research, which demonstrates their understanding of the music concept being taught. The following research is completed to enlighten music teachers of how to integrate technology within their music programme for PYP.
Inactivation of Factor VIIa by Antithrombin In Vitro, Ex Vivo and In Vivo: Role of Tissue Factor and Endothelial Cell Protein C Receptor
Creators: name: Vatsyayan, Rit
name: Rao, L. Vijaya Mohan
name: Mackman, Nigel
name: Kothari, Hema
name: Pendurthi, Usha R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulator of FVIIa. However, in vitro studies showed that AT could inhibit FVIIa effectively only when it was bound to tissue factor (TF). Circulating blood is known to contain only traces of TF, at best. FVIIa also binds endothelial cell protein C receptor (EPCR), but the role of EPCR on FVIIa inactivation by AT is unknown. The present study was designed to investigate the role of TF and EPCR in inactivation of FVIIa by AT in vivo. Low human TF mice (low TF, ∼1% expression of the mouse TF level) and high human TF mice (HTF, ∼100% of the mouse TF level) were injected with human rFVIIa (120 µg kg−1 body weight) via the tail vein. At varying time intervals following rFVIIa administration, blood was collected to measure FVIIa-AT complex and rFVIIa antigen levels in the plasma. Despite the large difference in TF expression in the mice, HTF mice generated only 40–50% more of FVIIa-AT complex as compared to low TF mice. Increasing the concentration of TF in vivo in HTF mice by LPS injection increased the levels of FVIIa-AT complexes by about 25%. No significant differences were found in FVIIa-AT levels among wild-type, EPCR-deficient, and EPCR-overexpressing mice. The levels of FVIIa-AT complex formed in vitro and ex vivo were much lower than that was found in vivo. In summary, our results suggest that traces of TF that may be present in circulating blood or extravascular TF that is transiently exposed during normal vessel damage contributes to inactivation of FVIIa by AT in circulation. However, TF’s role in AT inactivation of FVIIa appears to be minor and other factor(s) present in plasma, on blood cells or vascular endothelium may play a predominant role in this process.
Sull’Alcesti di Frinico: analisi di Phryn. fr. 2 Snell/Kannicht
Creators: name: Mancini, Nicola
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: In light of Euripides’ Alcestis, Phrynichus' fr. 2 Sn.-Kann. has been traditionally interpreted as a choral description of the fight between Heracles and Thanatos. Other interpretations regard Pheres as exhausted by old age or, alternatively, Alcestis as worn out by Thanatos. Following a meticulous analysis of the fragment, I propose that the verb τείρει should be understood as a second person singular in the medio-passive voice (< τείρῃ) and offer two possible interpretations of the excerptum.
description: Frammenti sulla Scena (online), N. 4 · 2023
Influence of Race on Microsatellite Instability and CD8+ T Cell Infiltration in Colon Cancer
Creators: name: Galanko, Joseph A.
name: Keku, Temitope O.
name: Ji, Ming
name: Tejada, Ruth
name: Yang, Bing
name: Smith, E. Julieta
name: Tajima, Akihiro
name: Sandler, Robert S.
name: Murali, Bhavya
name: McGuire, Kathleen L.
name: Kinseth, Matthew
name: Ngo, Tina
name: Carethers, John M.
name: Doctolero, Ryan T.
name: Lee, Monte
name: Miyai, Katsumi
name: Martin, Christopher F.
name: Janke, Ryan
name: Basa, Ranor
name: Cabrera, Betty L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies suggest a higher prevalence for microsatellite instability (MSI) among cancers from African Americans, albeit patients with MSI cancers have improved survival over patients with non-MSI cancers, counter to the outcome observed for African American patients. CD8+ T cell infiltration of colon cancer is postively correlated with MSI tumors, and is also related to improved outcome. Here, we utilized a 503-person, population-based colon cancer cohort comprising 45% African Americans to determine, under blinded conditions from all epidemiological data, the prevalence of MSI and associated CD8+ T cell infiltration within the cancers. Among Caucasian cancers, 14% were MSI, whereas African American cancers demonstrated 7% MSI (P = 0.009). Clinically, MSI cancers between races were similar; among microsatellite stable cancers, African American patients were younger, female, and with proximal cancers. CD8+ T cells were higher in MSI cancers (88.0 vs 30.4/hpf, P<0.0001), but was not different between races. Utilizing this population-based cohort, African American cancers show half the MSI prevalence of Caucasians without change in CD8+ T cell infiltration which may contribute towards their higher mortality from colon cancer.
Ideals defining Gorenstein rings are (almost) never products
Creators: name: Huneke, Craig
Publisher: name: arXiv
Year: 2014
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13

description: This note proves that if S is an unramified regular local ring and I and J are proper ideals of height at least two, then S/IJ is never Gorenstein.
description: This paper was published in 2007
Experimental investigation of the contaminated volume around a person in a clean room - Experimental data
Creators: name: Julia, Lange
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 600
subject: velocities
subject: cleanroom
subject: Clima2022
subject: measuring data

description: These are the experimental velocitiy data for the article 'Experimental investigation of the contaminated volume around a person in a clean room.', published at the Clima 2022 conference, REHVA 14th HVAC World Congress 22nd – 25th May 2022.