cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Difficulty-aware hierarchical convolutional neural networks for deformable registration of brain MR images
Creators: name: Ahmad, Sahar
name: Shen, Dinggang
name: Yap, Pew-Thian
name: Huang, Yunzhi
name: Fan, Jingfan
Publisher: name: Elsevier
Year: 2020

description: The aim of deformable brain image registration is to align anatomical structures, which can potentially vary with large and complex deformations. Anatomical structures vary in size and shape, requiring the registration algorithm to estimate deformation fields at various degrees of complexity. Here, we present a difficulty-aware model based on an attention mechanism to automatically identify hard-to-register regions, allowing better estimation of large complex deformations. The difficulty-aware model is incorporated into a cascaded neural network consisting of three sub-networks to fully leverage both global and local contextual information for effective registration. The first sub-network is trained at the image level to predict a coarse-scale deformation field, which is then used for initializing the subsequent sub-network. The next two sub-networks progressively optimize at the patch level with different resolutions to predict a fine-scale deformation field. Embedding difficulty-aware learning into the hierarchical neural network allows harder patches to be identified in the deeper sub-networks at higher resolutions for refining the deformation field. Experiments conducted on four public datasets validate that our method achieves promising registration accuracy with better preservation of topology, compared with state-of-the-art registration methods.
Immunogenicity and safety of single booster dose of KD-414 inactivated COVID-19 vaccine in adults: An open-label, single-center, non-randomized, controlled study in Japan
Creators: name: Terada-Hirashima, Junko
name: Takamatsu, Yuki
name: Shimizu, Yosuke
name: Uemura, Yukari
name: Takeuchi, Junko S.
name: Tomita, Noriko
name: Matsuda, Kouki
name: Maeda, Kenji
name: Yamamoto, Shohei
name: Fukunaga, Ami
name: Ohmagari, Norio
name: Mikami, Ayako
name: Sonoda, Kengo
name: Ujiie, Mugen
name: Mitsuya, Hiroaki
name: Sugiura, Wataru
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Although vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) induce effective immune responses, vaccination with booster doses is necessary because of waning immunity. We conducted an open-label, non-randomized, single-arm study in adults in Japan to assess the immunogenicity and safety of a single booster dose of the KD-414 purified whole-SARS-CoV-2-virion inactivated vaccine candidate after vaccination with a primary series of BNT162b2. The primary endpoint was serum neutralizing activity at 7 days after booster injection compared with the primary series of BNT162b2. The SARS-CoV-2-structural protein-binding antibody level and T cell response against SARS-CoV-2-Spike (S) peptides were also examined as secondary endpoints, and safety profile assessments were conducted. Twenty subjects who participated in a previous study declined an injection of KD-414 (non-KD-414 group) and received a booster dose of BNT162b2 instead. The non-KD-414 group was compared to the KD-414 group as a secondary outcome. A single dose of KD-414 induced lower serum neutralizing activity against the wild-type virus within 7 days compared to after the primary series of BNT162b2 but significantly induced anti-SARS-CoV-2-S1-receptor-binding domain-binding immunoglobulin G (IgG) antibodies and SARS-CoV-2-S peptide-specific CD4+ and CD8+ T cell responses. Local or systemic symptoms were significantly lower in the participants who received KD-414 than in those who received BNT162b2 as the third COVID-19 vaccine dose. The present data indicate that a single booster dose of KD-414 induces a substantial immune response in BNT162b2-primed individuals and has a good safety profile, thereby supporting further clinical trials to identify rational targets.
APPENDIX_A-D – Supplemental material for Using Media for Coping: A Scoping Review
Creators: name: Wolfers, Lara N.
name: Schneider, Frank M.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, APPENDIX_A-D for Using Media for Coping: A Scoping Review by Lara N. Wolfers and Frank M. Schneider in Communication Research
Supplemental_material - A socioecological perspective to understanding mental and physical health: The mediating role of relationship mindsets and goals
Creators: name: Hajin Lee
name: Lou, Nigel Mantou
name: Johnson, Matthew D.
name: Park, Sun W.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental_material for A socioecological perspective to understanding mental and physical health: The mediating role of relationship mindsets and goals by Hajin Lee, Nigel Mantou Lou, Matthew D. Johnson, and Sun W. Park in Journal of Social and Personal Relationships
Advancements in Transmitter and Receiver Components for Visible Light Communication Systems
Creators: name: Faruki, Md Jahid
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 510204
subject: Photonics, optoelectronics and optical communications
classificationCode: 400899
subject: Electrical engineering not elsewhere classified
classificationCode: 400608
subject: Wireless communication systems and technologies (incl. microwave and millimetrewave)

description: The high data demands of visible light communication (VLC) applications require transmitters with a high modulation bandwidth. Off-the-shelf LEDs have a limited bandwidth of 20 MHz, necessitating the development of micro-LEDs. This thesis identifies the crystal orientations in GaN micro-LED structures that offer the highest modulation bandwidth. The issue of low output power in micro-LEDs has been addressed by proposing optimized nano-sized hexagonal facet patterning (NSHFP) on the n-semiconductor bottom surfaces of the micro-LED, which enhances the output power by 75%. The proposed micro-LED chip demonstrates high-speed modulation capabilities while maintaining improved output power. Additionally, a single-stage YS-2 fiber-based fluorescent antenna is proposed to improve the field of view, coverage, and data rate performance of VLC.
Discovering cortical sulcal folding patterns in neonates using large-scale dataset
Creators: name: Li, Gang
name: Lin, Weili
name: Wang, Li
name: Meng, Yu
name: Gilmore, John H
name: Shen, Dinggang
Publisher: name: Wiley
Year: 2018

description: The folding of the human cerebral cortex is highly complex and variable across individuals, but certain common major patterns of cortical folding do exist. Mining such common patterns of cortical folding is of great importance in understanding the inter-individual variability of cortical folding and their relationship with cognitive functions and brain disorders. As primary cortical folds are mainly genetically influenced and are well established at term birth, neonates with minimal exposure to the complicated postnatal environmental influences are ideal candidates for mining the major patterns of cortical folding. In this paper, we propose a sulcal-pit-based method to discover the major sulcal patterns of cortical folding. In our method, first, the sulcal pattern is characterized by the spatial distribution of sulcal pits, which are the locally deepest points in cortical sulci. Since deep sulcal pits are genetically related, relatively consistent across individuals, and also stable during brain development, they are well suited for representing and characterizing the sulcal patterns. Then, the similarity between the distributions of sulcal pits is measured from the spatial, geometrical, and topological points of view. Next, a comprehensive similarity matrix is constructed for the whole dataset by adaptively fusing these measurements together, thus capturing both their common and complementary information. Finally, leveraging the similarity matrix, a hierarchical affinity propagation algorithm is used to group similar sulcal folding patterns together. The proposed method has been applied to 677 neonatal brains, and revealed multiple distinct and meaningful sulcal patterns in the central sulcus, superior temporal sulcus, and cingulate sulcus.
title: Histology of the salivary glands in unfed and feeding Rhipicephalus appendiculatus Neumann, 1901 (Ixodidae)
title: The histology of the salivary glands in unfed and feeding Rhipicephalus appendiculatus Neumann, 1901 (Ixodidae)
titleType: AlternativeTitle
Creators: name: Batungbacal, Marcela R.
Publisher: name: The University of Edinburgh
Year: 1974
Subjects: subject: salivary glands
subject: Rhipicephalus appendiculatus
subject: Type IV secretory alveoli
subject: 'f' cell
subject: methyl green - pyronin staining technique
subject: ixodid ticks
subject: Feulgen
subject: tick salivary glands

description: Salivary glands from adult Rhipicephalus appendiculatus Neumann, l90l were dissected, sectioned and stained :for histological examination. The glands were removed :from ticks at different stages of feeding. In general, the salivary glands of adult Rhipicephalus appendiculatus were similar to those which have been previously described in other ixodid species. The salivary glands o:f the male ticks differed histologically from those of the female in having Type IV secretory alveoli and the 'f' cell in the Type II alveoli. The glands were observed to undergo appreciable change in size and structure during the feeding process. They showed marked degenerative changes a:fter the ticks had detached from the host. The staining reactions of the salivary glands to biological stains were recorded. The possibility o:f using the methyl green - pyronin staining technique for detecting pathogens in whole tick salivary glands was also considered.
Immunogenicity of inactivated rotavirus in rhesus monkey, and assessment of immunologic mechanisms
Creators: name: Zhou, Yan
name: Wu, Jinyuan
name: Hu, Xiaoqing
name: Chen, Rong
name: Lin, Xiaochen
name: Yin, Na
name: Lu, Chenxing
name: Ye, Jun
name: Zhao, Yongmei
name: Song, Xiaopeng
name: Song, Zexin
name: Wang, Jinlan
name: Li, Yan
name: Li, Jinmei
name: Zhang, Guangming
name: Sun, Maosheng
name: Li, Hongjun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Rotavirus is one of the main pathogens causing severe diarrhea in infants and young children < 5 years of age. The development of the next-generation rotavirus vaccine is of great significance for preventing rotavirus infection and reducing severe mortality. The current study aimed to develop and evaluate the immunogenicity of inactivated rotavirus vaccine (IRV) in rhesus monkeys. Monkeys received two or three IRV injections intramuscularly at a 4-week interval. Neutralizing antibodies, cellular immunity, PBMC gene expression profiling, and immune persistence were evaluated. Three-dose immunization of IRV induced a higher level of neutralizing, IgG and IgA antibodies compared to two-dose immunization. IRV induced IFN-γ secretion to mediate cellular immune responses, including robust pro-inflammatory and antiviral responses. Chemokine-mediated signaling pathways and immune response were broadly activated by IRV injection. The IRV-induced neutralizing antibodies resulting from two doses returned to baseline levels 20 weeks after full immunization, while those resulting from three doses returned to baseline levels 44 weeks after full immunization. Increasing immunization dose and injection number will help to improve IRV immunogenicity and neutralizing antibody persistence.
Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder
Creators: name: Nelson, David W.
name: Amos-Kroohs, Robyn M.
name: Smith, Susan M.
name: Yen, Chi-Liang Eric
name: Hacker, Timothy A.
Publisher: name: Public Library of Science (PLoS)
Year: 2018

description: Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming. We tested this hypothesis in a mouse model of binge PAE, wherein pregnant C57Bl/6J females received 3 g/kg alcohol (ETOH) daily from gestational day 12.5 to 17.5; maltodextrin (MD) and medium chain triglycerides (MCT) served as isocaloric nutritional controls, and sham (H2O) treatment controlled for gavage stress. Our comprehensive assessment quantified body composition, energy expenditure, glucose tolerance, and cardiovascular function in offspring at age 17 weeks. Although ETOH pups were initially lighter than all other groups, they did not have a unique obesogenic phenotype. Instead, a similar obesogenic phenotype emerged in all three caloric groups (MCT, MD, ETOH), such that caloric groups had greater post-weaning weight gain (both sexes), reduced gonadal fat weight (males), and reduced glucose clearance (males) compared against H2O offspring. PAE did not affect body composition, respiratory exchange ratio, metabolic adaption to high-fat or low-fat diet, eating behavior, and blood pressure, and ETOH values did not differ from those obtained from isocaloric controls. Exposure to a higher alcohol dose (4.5 g/kg) or a high-fat (60%) diet did not exacerbate differences in body composition or glucose tolerance. "PAE-specific" effects on postnatal growth, glucose tolerance, adiposity, or hypertension only emerged when PAE offspring were compared just against H2O controls, or against MD controls. We conclude that prior reports of obesity and glucose intolerance in adult PAE offspring reflect the contribution of added gestational calories, and not alcohol's pharmacologic action. Results suggest that the increased adiposity risk in FASD is not caused by metabolic reprogramming, and instead originates from behavioral, medication, and/or dietary practices. This study highlights the importance of appropriate dietary controls in nutritional studies of PAE.
Impaired long-term anti-HBs responses in choronic hepatitis C patients: Results from a five-year follow-up study with healthy control
Creators: name: Yan, Bingyu
name: Lu, Jingjing
name: Jia, Liqiu
name: Feng, Yi
name: Wang, Jing
name: Meng, Xin
name: Liang, Xiaofeng
name: Wang, Fuzhen
name: Wan, Yanmin
name: Xu, Aiqiang
name: Zhang, Li
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Although hepatitis B virus (HBV) vaccination is recommended for hepatitis C virus (HCV)-infected individuals to avoid HBV superinfection, the persistence of their humoral and cell-mediated immunity responses to HBV vaccination is still under investigation. Patients with chronic hepatitis C (CHC) and matched healthy controls, who completed three doses of hepatitis B vaccine (HepB) in 2014, were followed up five years later. One booster dose of HepB was given to those with antibody against hepatitis B surface antigen (anti-HBs) lower than 10mIU/mL. Anti-HBs was tested at follow-up and on the 14th day after the booster dose, as well as HBsAg specific spot-forming cells of interferon γ and interleukin (IL) 2, 4, 5, and 6. At five years, only 56.58% of the CHC patients had sero-protective titers (≥10mIU/mL) of anti-HBs, compared to 70.83% in the controls (P < .05). Similarly, the geometric mean concentration (GMC) of anti-HBs in CHC patients was significantly lower than that in controls (16.95 vs 37.34 mIU/mL, P < .05). After the booster, both GMC and the rate of anamnestic response increased to a very high level in the two groups and the difference between them disappeared (P > .05). Multivariable analysis showed that HCV infection was an independent predictor factor to anti-HBs level at follow-up. HBsAg specific IL-6 was stronger in the CHC patients compared to the controls (P < .05). The data indicate that the durability of protective anti-HBs is poorer in CHC patients compared to healthy individuals, and impaired long-term anti-HBs responses might be associated with the increased HBsAg specific IL-6 responses.
Estimating the pertussis burden in adolescents and adults in the United States between 2007 and 2019
Creators: name: Macina, Denis
name: Mathur, Sachin
name: Dvaretskaya, Maryia
name: Ekhtiari, Sam
name: Hayat, Paul
name: Montmerle, Martin
name: Daluwatte, Chathuri
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Space Science
Medicine
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy
Computational Biology

description: We developed a machine learning algorithm to identify undiagnosed pertussis episodes in adolescent and adult patients with reported acute respiratory disease (ARD) using clinician notes in an electronic healthcare record (EHR) database. Here, we utilized the algorithm to better estimate the overall pertussis incidence within the Optum Humedica clinical repository from 1 January 2007 through 31 December 2019. The incidence of diagnosed pertussis episodes was 1–5 per 100,000 annually, consistent with data registered by the US Centers for Disease Control and Prevention (CDC) over the same time period. Among 18,573,496 ARD episodes assessed, 1,053,946 were identified (i.e. algorithm-identified) as likely undiagnosed pertussis episodes. Accounting for these undiagnosed pertussis episodes increased the estimated pertussis incidence by 110-fold on average (34–474 per 100,000 annually). Risk factors for pertussis episodes (diagnosed and algorithm-identified) included asthma (Odds ratio [OR] 2.14; 2.12–2.16), immunodeficiency (OR 1.85; 1.78–1.91), chronic obstructive pulmonary disease (OR 1.63; 1.61–1.65), obesity (OR 1.44; 1.43–1.45), Crohn’s disease (OR 1.39; 1.33–1.45), diabetes type 1 (OR 1.21; 1.17–1.24) and type 2 (OR 1.12; 1.1–1.13). Of note, all these risk factors, except Crohn’s disease, increased the likelihood of severe pertussis. In conclusion, the incidence of pertussis in the adolescent and adult population in the USA is likely substantial, but considerably under-recognized, highlighting the need for improved clinical awareness of the disease and for improved control strategies in this population. These results will help better inform public health vaccination and booster programs, particularly in those with underlying comorbidities.
Dual-domain convolutional neural networks for improving structural information in 3 T MRI
Creators: name: Shen, Dinggang
name: Zhang, Yongqin
name: Yap, Pew-Thian
name: Qu, Liangqiong
name: Cheng, Jie-Zhi
Publisher: name: Elsevier
Year: 2019

description: We propose a novel dual-domain convolutional neural network framework to improve structural information of routine 3T images. We introduce a parameter-efficient butterfly network that involves two complementary domains: a spatial domain and a frequency domain. The butterfly network allows the interaction of these two domains in learning the complex mapping from 3T to 7T images. We verified the efficacy of the dual-domain strategy and butterfly network using 3T and 7T image pairs. Experimental results demonstrate that the proposed framework generates synthetic 7T-like images and achieves performance superior to state-of-the-art methods.
Supplementary_Material - DRG-Derived Neural Progenitors Differentiate into Functional Enteric Neurons Following Transplantation in the Postnatal Colon
Creators: name: Hu, Hui
name: Yuanyuan Ding
name: Wenbo Mu
name: Li, Ying
name: Yanpeng Wang
name: Weifang Jiang
name: Fu, Yong
name: Jinfa Tou
name: Chen, Wei
Publisher: name: SAGE Journals
Year: 2018
Subjects: Medicine
Cell Biology

description: Supplementary_Material for DRG-Derived Neural Progenitors Differentiate into Functional Enteric Neurons Following Transplantation in the Postnatal Colon by Hui Hu, Yuanyuan Ding, Wenbo Mu, Ying Li, Yanpeng Wang, Weifang Jiang, Yong Fu, Jinfa Tou, and Wei Chen in Cell Transplantation
Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine (MenACYW-TT) administered as a booster to adults aged ≥59 years: A phase III randomized study
Creators: name: Robertson, Corwin A.
name: Jacqmein, Jeffry
name: Selmani, Alexandre
name: Galarza, Katherine
name: Oster, Philipp
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: This 2-stage Phase III study (NCT04142242) of a recently licensed quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) assessed the safety and immunogenicity of a booster dose in older adults (≥59 years) primed with either MenACYW-TT or a quadrivalent meningococcal polysaccharide vaccine (MPSV4). Immune persistence of MenACYW-TT and MPSV4 after primary vaccination was also evaluated. During Stage I, the participants administered MPSV4 (n = 165) or MenACYW-TT (n = 236) 3 years previously were randomized 9:2 to receive either a MenACYW-TT booster or to have blood drawn for persistence only. Participants primed with MPSV4 or MenACYW-TT 6–7 years previously had blood drawn for antibody persistence only. A serum bactericidal assay using human complement was used to measure functional antibodies against each serogroup at baseline and, for those receiving a booster, 30 days post-vaccination (D30). Proportions of participants with seroresponse (post-vaccination titers ≥1:16 when baseline titers <1:8 or ≥ 4-fold increase when baseline titers ≥1:8) were determined. Safety data were collected up to D30. Seroresponse rates for all serogroups at D30 ranged from 49.2% to 60.8% in the MPSV4-primed group, and 79.3–93.1% in the MenACYW-TT-primed group. MenACYW-TT induced sufficient seroresponses in each primed group. Geometric mean titers (GMTs) for serogroups C, W, and Y remained or trended higher than pre-vaccination levels at both 3 and 6–7 years after primary vaccination, indicating immune persistence. Safety outcomes were comparable between groups. A MenACYW-TT booster was immunogenic and well tolerated in participants aged ≥59 years regardless of previous quadrivalent meningococcal vaccine received. The greatest immune responses occurred in those primed with MenACYW-TT.
Suppl.__Doc._-_Mech_Table – Supplemental material for Initial balance in human standing postures: Roles of the joint mechanisms
Creators: name: Ashtiani, Mohammed N
name: Mahmood-Reza Azghani
name: Parnianpour, Mohamad
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, Suppl.__Doc._-_Mech_Table for Initial balance in human standing postures: Roles of the joint mechanisms by Mohammed N Ashtiani, Mahmood-reza Azghani and Mohamad Parnianpour in Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Supplementary_file__Appendix – Supplemental material for Consumer Information for Data-Driven Decision Making: Teaching Socially Responsible Use of Data
Creators: name: Walker, Kristen L.
name: Moran, Nora
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental material, Supplementary_file__Appendix for Consumer Information for Data-Driven Decision Making: Teaching Socially Responsible Use of Data by Kristen L. Walker and Nora Moran in Journal of Marketing Education
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency
Creators: name: Chao, Hui Xiao
name: Kumar, Sunil
name: Ramsden, Dale A
name: Shah, Sonam J
name: Kumar, Rashmi J
name: Cho, Min-Guk
name: Sullivan, Aurora R
name: Wozny, Anne-Sophie
name: Feng, Wanjuan
name: Gupta, Gaorav P
name: Purvis, Jeremy E
name: Luthman, Adam
name: Fagan-Solis, Katerina
name: Roberts, Victoria R
name: Simpson, Dennis A
Publisher: name: Oxford University Press (OUP)
Year: 2020

description: TP53 deficiency in cancer is associated with poor patient outcomes and resistance to DNA damaging therapies. However, the mechanisms underlying treatment resistance in p53-deficient cells remain poorly characterized. Using live cell imaging of DNA double-strand breaks (DSBs) and cell cycle state transitions, we show that p53-deficient cells exhibit accelerated repair of radiomimetic-induced DSBs arising in S phase. Low-dose DNA-dependent protein kinase (DNA-PK) inhibition increases the S-phase DSB burden in p53-deficient cells, resulting in elevated rates of mitotic catastrophe. However, a subset of p53-deficient cells exhibits intrinsic resistance to radiomimetic-induced DSBs despite DNA-PK inhibition. We show that p53-deficient cells under DNA-PK inhibition utilize DNA polymerase theta (Pol Ɵ)-mediated end joining repair to promote their viability in response to therapy-induced DSBs. Pol Ɵ inhibition selectively increases S-phase DSB burden after radiomimetic therapy and promotes prolonged G2 arrest. Dual inhibition of DNA-PK and Pol Ɵ restores radiation sensitivity in p53-deficient cells as well as in p53-mutant breast cancer cell lines. Thus, combination targeting of DNA-PK- and Pol Ɵ-dependent end joining repair represents a promising strategy for overcoming resistance to DNA damaging therapies in p53-deficient cancers.
Supplemental material for Extended two-stage adaptive designs with three target responses for phase II clinical trials
Creators: name: Seongho Kim
name: Weng Kee Wong
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material for Extended two-stage adaptive designs with three target responses for phase II clinical trials by Seongho Kim and Weng Kee Wong in Statistical Methods in Medical Research
Supplemental Material5 - Supplemental material for The COMiT’ID Study: Developing Core Outcome Domains Sets for Clinical Trials of Sound-, Psychology-, and Pharmacology-Based Interventions for Chronic Subjective Tinnitus in Adults
Creators: name: Hall, Deborah A.
name: Smith, Harriet
name: Hibbert, Alice
name: Colley, Veronica
name: Haúla F. Haider
name: Horobin, Adele
name: Londero, Alain
name: Mazurek, Birgit
name: Thacker, Brian
name: Fackrell, Kathryn
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, Supplemental Material5 for The COMiT’ID Study: Developing Core Outcome Domains Sets for Clinical Trials of Sound-, Psychology-, and Pharmacology-Based Interventions for Chronic Subjective Tinnitus in Adults by Deborah A. Hall, Harriet Smith, Alice Hibbert, Veronica Colley, Haúla F. Haider, Adele Horobin, Alain Londero, Birgit Mazurek, Brian Thacker, Kathryn Fackrell and for the Core Outcome Measures in Tinnitus (COMiT) initiative in Trends in Hearing
Immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age: A phase 2 randomized, double-blind trial
Creators: name: López, Pio
name: López-Medina, Eduardo
name: Sáez-Llorens, Xavier
name: deAntonio, Rodrigo
name: Masuda, Taisei
name: Mendelman, Paul M.
name: Sherwood, James
name: Baehner, Frank
name: Borkowski, Astrid
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: We conducted a dose-finding phase 2 study of the HilleVax bivalent virus-like particle (VLP) vaccine candidate (HIL-214) in two cohorts of children, 6–≤12 months and 1–≤4 years of age (N = 120 per cohort), in Panama and Colombia (ClinicalTrials.gov, identifier NCT02153112). On Day 1, children randomized to one of the four equal groups received intramuscular injections of four different HIL-214 formulations containing 15/15, 15/50, 50/50, or 50/150 μg of GI.1/GII.4c genotype VLPs and 0.5 mg Al(OH)3. On Day 29, half the children in each group received a second vaccination (N = 60), while the other half received saline placebo injections to maintain the blind. VLP-specific ELISA Pan-Ig and histo-blood group binding antigen-blocking antibodies (HBGA) were measured on Days 1, 29, 57 and 210. On Day 29, after one dose, there were large Pan-Ig and HBGA responses in both age cohorts with some indication of dose-dependence, and higher geometric mean titers (GMT) in the older children. A further increase in titers was observed 28 days after a second dose in the 6–≤12-month-old groups, but less so in the 1–≤4-year-old groups; GMTs at Day 57 were broadly similar across doses and in both age groups. GMTs of Pan-Ig and HBGA persisted above baseline up to Day 210. All formulations were well tolerated with mostly mild-to-moderate transient solicited adverse events reported by parents/guardians, and no vaccine-related serious adverse events occurred. Further development of HIL-214 is warranted to protect the most susceptible young children against norovirus.
GraspOS Deliverable 2.4 "OSAF Specifications for Pilots"
Creators: name: Tatum, Clifford
name: Zeynep, Anli
name: Vergoulis, Thanasis
name: Polonen, Janne
name: Ivanović, Dragan
name: Nordling, Josefine
name: Sipola, Tiina
name: Koivisto, Elina
name: Mira Söderman, Mira
Publisher: name: Zenodo
Year: 2024
Subjects: Open Science
EOSC
Research Assessment

description: The Open Science Assessment Framework (OSAF) promotes Responsible Research Assessment (RRA) by emphasizing the evaluation of Open Science practices through both process and infrastructure. This document outlines the elements of the Openness Profile, Assessment Portfolio, and Assessment Registry, which are digital tools supported by the RAiD identifier system to enhance transparency and collaboration in research evaluations. Together, the OSAF method and infrastructure enable adaptable, context-sensitive research assessment while integrating outcomes with broader research information systems.

 
description: The deliverable awaits official approval by the Project Officer. This project has received funding from the European Union’s Horizon Europe framework programme under grant agreement No. 101095129. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the European Research Executive Agency can be held responsible for them.
revised_supplementary_material_(1) – Supplemental material for A comparison of logistic regression models with alternative machine learning methods to predict the risk of in-hospital mortality in emergency medical admissions via external validation
Creators: name: Faisal, Muhammad
name: Scally, Andy
name: Howes, Robin
name: Beatson, Kevin
name: Richardson, Donald
name: Mohammed, Mohammed A
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplemental material, revised_supplementary_material_(1) for A comparison of logistic regression models with alternative machine learning methods to predict the risk of in-hospital mortality in emergency medical admissions via external validation by Muhammad Faisal, Andy Scally, Robin Howes, Kevin Beatson, Donald Richardson and Mohammed A Mohammed in Health Informatics Journal
Appendix – Supplemental material for The Effects of Polarization on Ideological Certainty: An Application to Executive Order Issuance
Creators: name: Brockway, Mark
name: Hollibaugh, Gary E.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, Appendix for The Effects of Polarization on Ideological Certainty: An Application to Executive Order Issuance by Mark Brockway and Gary E. Hollibaugh in American Politics Research
Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation
Creators: name: Dammann, Olaf
name: O'Shea, T Michael
name: Kuban, Karl
name: VanderVeen, Deborah K
name: Fichorova, Raina N
name: Allred, Elizabeth N
name: Leviton, Alan
Publisher: name: Thieme
Year: 2019

description: OBJECTIVE: To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins with inflammatory, neurotrophic, or angiogenic properties. STUDY DESIGN: Using multiplex immunoassays, we measured the concentrations of IGF-1 and IGFBP-1, as well as 25 other proteins in blood spots collected weekly from≥880 infants born before the 28th week of gestation, and sought correlates of concentrations in the top and bottom quartiles for gestational age and day the specimen was collected. RESULTS: Medically indicated delivery and severe fetal growth restriction (sFGR) were associated with low concentrations of IGF-1 on the first postnatal day and with high concentrations of IGFBP-1 on almost all days. Elevated concentrations of IGF-1 and IGFBP-1 were accompanied by elevated concentrations of many other proteins with inflammatory, neurotrophic, or angiogenic properties. CONCLUSION: Disorders associated with impaired placenta implantation and sFGR appear to account for a relative paucity of IGF-1 on the first postnatal day. Elevated concentrations of IGF-1 and especially IGFBP-1 were associated with same-day elevated concentrations of inflammatory, neurotrophic, and angiogenic proteins.
Supplemental material for Carotid surgical cut-down technique for neuroendovascular therapy
Creators: name: Takano, Issei
name: Matsumoto, Yoshiyuki
name: Fujii, Yoshiko
name: Inoue, Yuki
name: Sugiura, Yoshiki
name: Kawamura, Yosuke
name: Suzuki, Ryotaro
name: Ryuta Nakae
name: Tanaka, Yoshihiro
name: Nagaishi, Masaya
name: Takigawa, Tomoji
name: Hyodo, Akio
name: Suzuki, Kensuke
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental Material for Carotid surgical cut-down technique for neuroendovascular therapy by Issei Takano, Yoshiyuki Matsumoto, Yoshiko Fujii, Yuki Inoue, Yoshiki Sugiura, Yosuke Kawamura, Ryotaro Suzuki, Ryuta Nakae, Yoshihiro Tanaka, Masaya Nagaishi, Tomoji Takigawa, Akio Hyodo and Kensuke Suzuki in Interventional Neuroradiology
Studies on charge production from Cs$_2$Te photocathodes in the PITZ L-band normal conducting radio frequency photo injector
Creators: name: Hernandez-Garcia, Carlos
name: Kraslinikov, M.
name: Asova, G.
name: Bakr, M.
name: Boonpornprasert, P.
name: Good, J.
name: Gross, M.
name: Huck, H.
name: Isaev, I.
name: Kalantaryan, D.
name: Khojoyan, M.
name: Kourkafas, G.
name: Lishilin, O.
name: Malyutin, D.
name: Melkumyan, D.
name: Oppelt, A.
name: Otevrel, M.
name: Pathak, G.
name: Renier, Y.
name: Rublack, T.
name: Stephan, F.
name: Vashchenko, G.
name: Zhao, Q.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: (2016).
description: This paper discusses the behavior of electron bunch charge produced in an L-band normal conducting radio frequency cavity (RF gun) from Cs2Te photocathodes illuminated with ps-long UV laser pulses when the laser transverse distribution consists of a flat-top core with Gaussian-like decaying halo. The produced charge shows a linear dependence at low laser pulse energies as expected in the quantum efficiency limited emission regime, while its dependence on laser pulse energy is observed to be much weaker for higher values, due to space charge limited emission. However, direct plug-in of experimental parameters into the space charge tracking code ASTRA yields lower output charge in the space charge limited regime compared to measured values. The rate of increase of the produced charge at high laser pulse energies close to the space charge limited emission regime seems to be proportional to the amount of halo present in the radial laser profile since the charge from the core has saturated already. By utilizing core + halo particle distributions based on measured radial laser profiles, ASTRA simulations and semi-analytical emission models reproduce the behavior of the measured charge for a wide range of RF gun and laser operational parameters within the measurement uncertainties.
Safety and immunogenicity of a bivalent HPV16/18 vaccine in Chinese females
Creators: name: Shi, Li-Wei
name: Li, Juan
name: Yu, Bang-Wei
name: Huang, Li-Rong
name: Li, Ke
name: Ji, Min
name: Zhou, Ling-Yun
name: Yuan, Lin
name: Yang, Shu-Yuan
name: Chen, Jing-Jing
name: Wang, Ling
name: Jiang, Zhi-Wei
name: Li, Rong-Cheng
name: Li, Yan-Ping
name: Xia, Jie-Lai
name: Mo, Zhao-Jun
name: Li, Chang-Gui
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: As global supply is still inadequate to address the worldwide requirements for HPV vaccines, we assessed the safety and immunogenicity of a new bivalent HPV16/18 vaccine. In this randomized, double-blind, placebo-controlled, phase 2 trial, healthy 9–45-year-old Chinese females in three age cohorts (600 aged 9–17 years; 240 aged 18–26 years; 360 aged 27–45 years) were randomized 1:1 to receive three doses (0,2,6 months) of HPV16/18 vaccine or placebo. We measured neutralizing antibodies against HPV 16 and 18 at 7 months and monitored safety to 12 months in all age cohorts; 9–17-year-old girls were monitored for safety and immunogenicity to 48 months. In vaccinees, 99.8% seroconverted for HPV 16 and 18 types at 7 months; respective GMTs of 5827 (95% CI: 5249, 6468) and 4223 (3785, 4713) were significantly (p < .001) higher than controls for all comparisons. GMTs in the 9–17-year-olds, which were significantly higher than in older women at 7 months, gradually declined to 48 months but remained higher than placebo with seropositivity rates maintained at 98.5% and 97.6% against HPV 16 and 18, respectively. Adverse events occurred at similar rates after vaccine and placebo (69.8% vs. 72.5%, p = .308), including solicited local reactions and systemic adverse events which were mainly mild-to-moderate. The bivalent HPV16/18 vaccine was well tolerated and induced high levels of neutralizing antibodies in all age groups which persisted at high levels to 48 months in the 9–17-year-old age group which would be the target for HPV vaccination campaigns.
eHealth to Enhance Treatment Adherence Among Youth Living with HIV
Creators: name: Hightow-Weidman, Lisa B.
name: Mulawa, Marta I.
name: LeGrand, Sara
Publisher: name: Springer Nature
Year: 2018

description: Purpose of reviewMultiple reviews have examined eHealth/mHealth interventions to address treatment adherence, including those focusing on youth living with HIV (YLWH). This review synthesizes results of prior reviews and recent studies (last 5 years) to provide a path forward for future research, acknowledging both lessons learned and gaps to be addressed.Recent findingsRecent studies provide further evidence for the feasibility and acceptability of technology-based HIV interventions. Formative research of more comprehensive smartphone applications and pilot studies of computer-delivered interventions provide additional guidance on YLWH's preferences for intervention components and show promising preliminary efficacy for impacting treatment adherence.SummaryExpanding access to technology among YLWH, in the United States (US) and globally, supports the continued focus on eHealth/mHealth interventions as a means to reduce disparities in clinical outcomes. Future research should lend greater focus to implementation and scale-up of interventions through the use of adaptive treatment strategies that include costing analyses, measuring and maximizing engagement, fostering information sharing between researchers, and building upon sustainable platforms.
Supplemental Material, APPENDIX.Survey_Questionnaire_Final - Healthcare Providers’ Attitudes, Knowledge, and Practice Behaviors for Educating Patients About Advance Directives: A National Survey
Creators: name: Nedjat-Haiem, Frances R.
name: Cadet, Tamara J.
name: Anup Amatya
name: Mishra, Shiraz I.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care

description: Supplemental Material, APPENDIX.Survey_Questionnaire_Final for Healthcare Providers’ Attitudes, Knowledge, and Practice Behaviors for Educating Patients About Advance Directives: A National Survey by Frances R. Nedjat-Haiem, Tamara J. Cadet, Anup Amatya, and Shiraz I. Mishra in American Journal of Hospice and Palliative Medicine®
sup_mat_sjp_812638 – Supplemental material for Can a poor psychosocial work environment and insufficient organizational resources explain the higher risk of ill-health and sickness absence in human service occupations? Evidence from a Swedish national cohort
Creators: name: Aronsson, Vanda
name: Toivanen, Susanna
name: Leineweber, Constanze
name: Nyberg, Anna
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sup_mat_sjp_812638 for Can a poor psychosocial work environment and insufficient organizational resources explain the higher risk of ill-health and sickness absence in human service occupations? Evidence from a Swedish national cohort by Vanda Aronsson, Susanna Toivanen, Constanze Leineweber and Anna Nyberg in Scandinavian Journal of Public Health
Electronic Dose Monitoring Device Patterns in Youth Living With HIV Enrolled in an Adherence Intervention Clinical Trial
Creators: name: Heckman, Barbara
name: Johnson, Megan Mueller
name: Gaur, Aditya H.
name: Lindsey, Jane C.
name: Horvath, Keith J.
name: Hudgens, Michael
name: Dallas, Ronald
name: Amico, K. Rivet
Publisher: name: Wolters Kluwer
Year: 2023

description: INTRODUCTION: Youth living with HIV in the US have low rates of viral suppression, in part because of challenges with antiretroviral therapy adherence. METHODS: Daily dosing in the Adolescent Medicine Trials Network for HIV/AIDS Interventions 152 study, a randomized controlled trial of a 12-week adherence intervention (triggered escalating real-time adherence intervention) for viremic youth, compared with standard of care (SOC), was measured by electronic dose monitoring (EDM) throughout 48 weeks of follow-up. EDM data collected over the first 24 weeks were used to characterize patterns of antiretroviral therapy adherence with group-based trajectory models. RESULTS: Four trajectory groups were identified among the 85 participants included in the analysis during the intervention phase of the study: (Worst) no interaction with EDM, (Declining) initially moderate EDM-based adherence followed by steep declines, (Good) initially high EDM-based adherence with modest declines, and (Best) consistently high EDM-based adherence. Being in the SOC arm, not being in school, higher evasiveness and panic decision-making scores, and lower adherence motivation were associated with higher odds of being in a worse trajectory group ( P < 0.05). A general decline in dosing was observed in the 12 weeks postintervention, when all participants were managed using SOC. CONCLUSIONS: Use of group-based trajectory models allowed a more nuanced understanding of EDM-based adherence over time compared with collapsed summary measures. In addition to the study intervention, other factors influencing EDM-based adherence included being in school, decision-making styles, and adherence-related motivation. This information can be used to design better intervention services for youth living with HIV.
Supplemental Material, jmr.15.0479-web-appendix - The Effect of Perceived Similarity on Sequential Risk Taking
Creators: name: Webb, Elizabeth C.
name: Shu, Suzanne B.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, jmr.15.0479-web-appendix for The Effect of Perceived Similarity on Sequential Risk Taking by Elizabeth C. Webb, and Suzanne B. Shu in Journal of Marketing Research
Timing Measurement in the CALICE Analogue Hadronic Calorimeter
Creators: name: Brianne, Eldwan
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: AHCAL Main Meeting, Hamburg, DESY, Germany, 15 Dec 2016 - 16 Dec 2016 ; (2016).
Supplementary_File - Economic Evaluation of an Integrated Health and Social Care Program for Heart Failure Through 2 Different Modeling Techniques
Creators: name: Larrañaga, Igor
name: Stafylas, Panos
name: Fullaondo, Ane
name: Apuzzo, Gian Matteo
name: Mar, Javier
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplementary_File for Economic Evaluation of an Integrated Health and Social Care Program for Heart Failure Through 2 Different Modeling Techniques by Igor Larrañaga, Panos Stafylas, Ane Fullaondo, Gian Matteo Apuzzo, Javier Mar, and on behalf of the SmartCare Modeling Group in Health Services Research and Managerial Epidemiology
Analysis of CERN 2015 Test Beam Data of the AHCAL engineering prototype
Creators: name: Provenza, Ambra
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: DPG, Hamburg, DESY, Germany, 29 Feb 2016 - 4 Mar 2016 ; (2016).
description: The goal of the CALICE Collaboration is to develop calorimeters for a future e + e − linear collider. The Analog Hadronic Calorimeter (AHCAL) is a high granularity calorimeter, developed to use the Particle Flow method, to reach a good jet energy resolution. The AHCAL technological prototype, scalable to full collider detector, is composed of 3 × 3 cm ^2 scintillator tiles read out by Silicon Photomultipliers. During the year 2015 two periods of test beams at CERN have been performed, to validate the detector calibration with muon and electron beams, to study the shower evolution with hadron beams, and compare two different kinds of absorber material: steel and tungsten absorber. This talk will focus on the analysis of the test beam data taken at CERN, with particular stress on the calibration of the detector and compare these results with the Monte Carlo simulation.