cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanistic characterisation of Activin/Smad and PI3K/mTOR crosstalk during the specification of definitive endoderm from human embryonic stem cells
Creators: name: Yu, Jason Shu Lim
Publisher: name: Imperial College London
Year: 2015

description: During the course of development, specification of the three embryonic germ layers, ectoderm, mesoderm and definitive endoderm (DE), is a critical process by which pluripotent cells acquire the temporal and spatial information needed to form specialised tissues. Of these initial germ layers, the DE arises during gastrulation, which latterly gives rise to the liver, pancreas, lung and epithelial lining of the digestive tract. Elucidation of the molecular mechanisms that govern DE specification not only facilitates our understanding of developmental biology but also aids in the differentiation of human pluripotent stem cells to specific cell types for disease modelling and regenerative therapies. DE formation is largely driven by the cooperation of Activin/Nodal and Wnt/β-catenin signalling, however recent evidence has additionally implicated PI3K/Akt signalling in modulating this process. Although it has been previously reported that PI3K activation acts to antagonise the in vitro differentiation of DE, the molecular mechanisms responsible for this effect remains unclear. To address this issue, this study utilises pluripotent human embryonic stem cells (hESCs) as an in vitro model to interrogate the molecular underpinnings of DE formation through a fully defined differentiation protocol. Modulation of PI3K activity was found to reciprocally downregulate the activation of Smad2/3, which was mitigated in the presence of the PI3K inhibitor LY294002 (LY). Suppression of PI3K/Akt signalling prolongs the activation of Smad2/3 in response to Activin, promoting their nuclear accumulation and the enhancement of transcriptional activity, resulting in the upregulation of mesendoderm and DE gene expression. Activation of PI3K negatively impacts the activity of Smad2/3 via phosphorylation of the Smad2/3 linker T220/T179 residue, which is fully independent of Erk and CDK activity. Phosphorylation of this residue induces the recruitment of the E3 ubiquitin ligase Nedd4L to activated Smad2/3, which in turn promotes their ubiquitin-mediated degradation and attrition of activity. Inhibition of mTORC2 activity by both inhibitor supplementation and genetic manipulation, rather than modulation of Akt or mTORC1 activity, recapitulates the LY-mediated reduction of T220/T179 phosphorylation and increases the duration of Smad2/3 transcriptional activity, promoting a more robust mesendoderm and endoderm differentiation. These findings reveal a new and novel connection between the PI3K/mTOR and TGFβ/Activin pathways, which will greatly impact our understanding of both cell fate determination and the preservation of normal cellular functions. Notably, identification of mTORC2 as a key player in the regulation of this differentiation provides new avenues through which hESCs differentiation protocols can be improved for both regenerative and biomedical applications.
Lab-on-a-chip device to quantify buffer capacity of blood
Creators: name: Gandhi, Sahir
Publisher: name: Imperial College London
Year: 2015

description: An accurate estimation of physiological buffer capacity and total titratable buffer concentration of blood can give a great deal of insight into the physiological stability of a patient and yet it remains an undervalued diagnostic marker. This thesis highlights the need for a lab-on-chip device to quantify buffer capacity of whole blood samples by estimating the total titratable buffer concentration. Buffer capacity is quantified by titrating the buffer to its end point using monoprotic acids. More sophisticated ways include electrolytic titration, i.e. producing a proton flux using electrodes in a controlled environment. This thesis looks at a novel approach to electrolytic (coulometric) titration by inhibiting the production of OH ions during electrolysis and titrating the sample due to the proton flux from the anode. By definition, is the amount of acid or base added to change the pH of 1 litre of buffer by 1 pH unit. The carbonic acid bicarbonate buffer system is the most important buffer that maintains the body’s pH within a stable range. To quantify this buffer’s total buffering concentration, it is important to know and indicate its titration end point which signifies the total exhaustion of all buffering constituents. Colorimetric indicators have been used to indicate this end point which can be quantified through cameras or spectrophotometric techniques. Using this novel coulometric titrator and the colorimetric end point detector, this thesis presents a portable lab-on-chip prototype to spectrophotometrically quantify total titratable buffer concentration. Clinically, this device could benefit patients with sickle cell disease, nephritic disease and those admitted in accident and emergency wards. This research work is aimed at presenting a proof-of-concept for a device that can titrate nano-litre samples and be able to detect the end point of a titration in a controlled way.
Additional file 1: of Immunogenicity of the CYD tetravalent dengue vaccine using an accelerated schedule: randomised phase II study in US adults
Creators: name: Kirstein, Judith
name: Douglas, William
name: Thakur, Manoj
name: Boaz, Mark
name: Papa, Thomas
name: Skipetrova, Anna
name: Plennevaux, Eric
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Methods. PRNT assay. Additional information on the methods for the PRNT assay and serostatus at baseline. (DOCX 38 kb)
Expected characteristics of the subclass of Supernova Gamma-ray Bursts (S-GRBs)
Creators: name: Bloom, J. S.
name: Kulkarni, S. R.
name: Harrison, F.
name: Prince, T.
name: Phinney, E. S.
name: Frail, D. A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The spatial and temporal coincidence between the gamma-ray burst (GRB) 980425 and supernova (SN) 1998bw has prompted speculation that there exists a class of GRBs produced by SNe (``S-GRBs''). Robust arguments for the existence of a relativistic shock have been presented on the basis of radio observations. A physical model based on the radio observations lead us to propose the following characteristics of supernovae GRBs (S-GRBs): 1) prompt radio emission and implied brightness temperature near or below the inverse Compton limit, 2) high expansion velocity of the optical photosphere as derived from lines widths and energy release larger than usual, 3) no long-lived X-ray afterglow, and 4) a single pulse (SP) GRB profile. Radio studies of previous SNe show that only type Ib and Ic potentially satisfy the first condition. Accordingly we have investigated proposed associations of GRBs and SNe finding no convincing evidence (mainly to paucity of data) to confirm any single connection of a SN with a GRB. If there is a more constraining physical basis for the burst time-history of S-GRBs beyond that of the SP requirement, we suggest the 1% of light curves in the BATSE catalogue similar to that of GRB 980425 may constitute the subclass. Future optical follow-up of bursts with similar profiles should confirm if such GRBs originate from some fraction of SN type Ib/Ic.
description: 11 pages of LaTeX with 1 figure. Submitted to the Astrophysical Journal Letters
Helianthus angustifolia Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Helianthus
Helianthus angustifolia

description: Rudbeckia angustifolia (Linnaeus) Linnaeus, Species Plantarum, ed. 2, 2: 1281. 1763.
"Habitat in Virginia." RCN: 6555.
Basionym: Coreopsis angustifolia L. (1753).
Lectotype (Reveal in Jarvis & Turland in Taxon 47: 359. 1998): Clayton 667 (BM-000051730).
Current name: Helianthus angustifolia L. (Asteraceae).
Note: As noted by Reveal, Fernald (in Rhodora 49: 190, pl. 1084, f. 1. 1947) treated Clayton 667 as the type of Helianthus angustifolius L. (1753), a name for which it is not original material.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 801, DOI: 10.5281/zenodo.291971
The role of the histone demethylase Jmjd2c/Kdm4c in mouse embryonic stem cell pluripotency
Creators: name: Tomaz, Rute Alexandra Da Costa
Publisher: name: Imperial College London
Year: 2015

description: The development of a whole organism from a single fertilised egg is a tightly orchestrated process at the molecular level. Signalling pathways stimulate the expression of transcription factors that in turn coordinate the activation, repression or priming of genes through multi-protein complex assembly and chromatin remodelling at regulatory regions during key developmental transitions. This project focuses on the role of the chromatin modifier Jmjd2c/Kdm4c in embryonic stem cell (ESC) pluripotency. Jmjd2c is a member of Jmjd2 H3K9-demethylase family, which is highly expressed in ESCs and during early mouse development, and was proposed to contribute to ESC identity. Here, Jmjd2c-depleted ESCs were generated and found to sustain an undifferentiated state. In contrast, these cells fail to execute multi-lineage differentiation, as evidenced by their inability to fully activate appropriate gene expression programs, but readily adopt an extra-embryonic endoderm-like phenotype under appropriate conditions. Moreover, Jmjd2c-knockout ESCs can transit to an early epiblast stage and be stably converted into epiblast stem cells (cEpiSCs) that harbour an immature state as highlighted by a lack of transcriptional gene priming for germ layer markers. In order to unfold the mechanistic basis for the observed differentiation defect, genome-wide distribution of Jmjd2c was analysed by ChIP-sequencing. This revealed prominent binding to the TSS of active and bivalently marked genes, concordant with recent reports. Remarkably, acquisition of multi-lineage priming in ESCs was accompanied by Jmjd2c recruitment at poised enhancers of lineage-affiliated genes. Surprisingly, these regions were co-occupied by the H3K9-methyltransferase G9a/Ehmt2, which physically interacts with Jmjd2c and Mediator, within chromatin-bound complexes. Critically, the absence of Jmjd2c in cEpiSCs was sufficient to destabilize the assembly of enhancer protein complexes, suggesting a scaffolding role independent of its H3K9-demethylase activity. Collectively, this study uncovered a novel role for Jmjd2c in regulating gene expression at exit of the pluripotent state.
Towards practical linear optical quantum computing
Creators: name: Gimeno-Segovia, Mercedes
Publisher: name: Imperial College London
Year: 2015

description: Quantum computing promises a new paradigm of computation where information is processed in a way that has no classical analogue. There are a number of physical platforms conducive to quantum computation, each with a number of advantages and challenges. Single photons, manipulated using integrated linear optics, constitute a promising platform for universal quantum computation. Their low decoherence rates make them particularly favourable, however the inability to perform deterministic two-qubit gates and the issue of photon loss are challenges that need to be overcome. In this thesis we explore the construction of a linear optical quantum computer based on the cluster state model. We identify the different necessary stages: state preparation, cluster state construction and implementation of quantum error correcting codes, and address the challenges that arise in each of these stages. For the state preparation, we propose a series of linear optical circuits for the generation of small entangled states, assessing their performance under different scenarios. For the cluster state construction, we introduce a ballistic scheme which not only consumes an order of magnitude fewer resources than previously proposed schemes, but also benefits from a natural loss tolerance. Based on this scheme, we propose a full architectural blueprint with fixed physical depth. We make investigations into the resource efficiency of this architecture and propose a new multiplexing scheme which optimises the use of resources. Finally, we study the integration of quantum error-correcting codes in the linear optical scheme proposed and suggest three ways in which the linear optical scheme can be made fault-tolerant.
Clock Distribution and Readout Architecture for the ATLAS Tile Calorimeter at the HL-LHC
Creators: name: Carrió, F.
name: Valero, A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The Tile Calorimeter (TileCal) is one detector of the ATLAS experiment at the Large Hadron Collider (LHC). TileCal is a sampling calorimeter made of steel plates and plastic scintillators which are readout using approximately 10,000 PhotoMultipliers Tubes (PMTs). In 2024, the LHC will undergo a series of upgrades towards a High Luminosity LHC (HL-LHC) to deliver up to 7.5 times the current nominal instantaneous luminosity. The ATLAS Tile Phase II Upgrade will accommodate detector and Data AcQuisition (DAQ) system to the HL-LHC requirements. The detector electronics will be redesigned using a new clock distribution and readout architecture with a full-digital trigger system. After the Long Shutdown 3 (2024-2026), the on-detector electronics will transfer digitized data for every bunch crossing (~25 ns) to the Tile PreProcessors (TilePPr) in the counting rooms with a total data bandwidth of 40 Tbps. The TilePPrs will store the detector data in pipeline memories to cope with the new ATLAS DAQ architecture requirements, and will interface with the Front End Link eXchange (FELIX) system and the first trigger level. The TilePPr boards will distribute the sampling clock to the on-detector electronics for synchronization with the LHC clock using high-speed links configured for fixed and deterministic latency. The upgraded readout and clock distribution strategy was fully validated in a Demonstrator system using prototypes of the upgraded electronics in several test beam campaigns between 2015 and 2018.
Additional file 2 of Mobile rehabilitation support versus usual care in patients after total hip or knee arthroplasty: study protocol for a randomised controlled trial
Creators: name: Wang, Qingling
name: Hunter, Sharyn
name: Lee, Regina Lai-Tong
name: Wang, Xiaofeng
name: Chan, Sally Wai-Chi
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Mental Health

description: Additional file 2. Content of the mobile app-support rehabilitation program.
The evolution of diversity and life history traits in annual killifish (Austrolebias) and other Cyprinodontiformes
Creators: name: Helmstetter, Andrew
Publisher: name: Imperial College London
Year: 2015

description: Members of the annual killifish genus Austrolebias live in temporary ponds across South America and possess a remarkable life cycle. These fish live in small ponds that dry out completely; killing the adults but not before they have laid eggs in the substrate of their pond. The desiccation-resistant eggs develop during the dry season, going through multiple stages of diapause until the next wet season rains trigger hatching and the cycle is repeated. There is considerable variation in size in Austrolebias, the largest species can reach up to 150mm in length while the typical size is just 40mm. Phylogenetic trees and species distribution models were built and used together to identify the factors that influence patterns of co-occurrence within this genus. Differences in growth and morphology among Austrolebias species were examined to quantify how differences in growth pattern can lead to the large variation in size and shape seen within the genus. Genomic data was generated for hybrid offspring of two species of Austrolebias using double-digest RAD sequencing. These data were then used to build linkage maps that were in turn used to identify any regions associated with sex determination and potential chromosomal rearrangements. At a broader scale, a generic-level tree for the order Cyprinodontiformes was constructed. Austrolebias is a member of this order, as well as many model fish genera such as Fundulus, Nothobranchius and Poecilia. Two extraordinary reproductive life-history adaptations have evolved in this order; viviparity and annualism. The new tree was used to determine whether the evolution of viviparity or annualism lead to increased rates of diversification. Finally this generic-level tree was used to examine patterns of positive selection in the low-light vision gene, rhodopsin and whether sites under selection were linked to functional changes.
THE ORIGIN OF PLUTO'S ORBIT: IMPLICATIONS FOR THE SOLAR SYSTEM BEYOND NEPTUNE
Creators: name: Malhotra, Renu
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The origin of the highly eccentric, inclined, and resonance-locked orbit of Pluto has long been a puzzle. A possible explanation has been proposed recently [Malhotra, R., {\it Nature} 365:819-21 (1993)] which suggests that these extraordinary orbital properties may be a natural consequence of the formation and early dynamical evolution of the outer Solar system. A resonance capture mechanism is possible during the clearing of the residual planetesimal debris and the formation of the Oort Cloud of comets by planetesimal mass loss from the vicinity of the giant planets. If this mechanism were in operation during the early history of the planetary system, the entire region between the orbit of Neptune and approximately 50 AU would have been swept by first order mean motion resonances. Thus, resonance capture could occur not only for Pluto, but quite generally for other trans-Neptunian small bodies. Some consequences of this evolution for the present-day dynamical structure of the trans-Neptunian region are: (i) most of the objects in the region beyond Neptune and up to $\sim\!50$ AU exist in very narrow zones located at orbital resonances with Neptune (particularly the 3:2 and the 2:1 resonances), and (ii) these resonant objects would have significantly large eccentricities. The distribution of objects in the Kuiper Belt as predicted by this theory is presented here. Keywords{solar system: origins, dynamics --- Pluto --- comets --- Kuiper Belt}
description: 14 pages, uuencoded compressed postscript file (including figures); to appear in the Astronomical Journal
Rudbeckia hirta Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Rudbeckia
Rudbeckia hirta

description: Rudbeckia hirta Linnaeus, Species Plantarum 2: 907. 1753.
"Habitat in Virginia, Canada." RCN: 6552.
Lectotype (Fernald & Schubert in Rhodora 50: 173, pl. 1102. 1948): Herb. Linn. No. 1025.4 (LINN).
Current name: Rudbeckia hirta L. (Asteraceae).
Note: Rudbeckia hirta L. was treated as the generitype by Britton & Brown (Ill. Fl. N. U. S., ed. 2, 3: 469. 1913; see McNeill & al. in Taxon 36: 382. 1987). However, under Art. 10.5, Ex. 7 (a voted example) of the Vienna Code, this is a type choice made under the American Code and is to be replaced under Art. 10.5b by Green’s choice (Prop. Brit. Bot.: 183. 1929) of R. laciniata L.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 801, DOI: 10.5281/zenodo.291971
Additional file 2: of Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations
Creators: name: Tambets, Kristiina
name: Bayazit Yunusbayev
name: Hudjashov, Georgi
name: Anne-Mai IlumĂ¤E
name: Rootsi, Siiri
name: Honkola, Terhi
name: Vesakoski, Outi
name: Atkinson, Quentin
name: Skoglund, Pontus
name: Kushniarevich, Alena
name: Litvinov, Sergey
name: Maere Reidla
name: Metspalu, Ene
name: Saag, Lehti
name: Rantanen, Timo
name: Karmin, Monika
name: JĂźri Parik
name: Zhadanov, Sergey
name: Gubina, Marina
name: Damba, Larisa
name: Bermisheva, Marina
name: Reisberg, Tuuli
name: Khadizhat Dibirova
name: Evseeva, Irina
name: Nelis, Mari
name: Klovins, Janis
name: Metspalu, Andres
name: TĂľnu Esko
name: Balanovsky, Oleg
name: Balanovska, Elena
name: Khusnutdinova, Elza
name: Osipova, Ludmila
name: Voevoda, Mikhail
name: Villems, Richard
name: Kivisild, Toomas
name: Metspalu, Mait
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Table S2. Ethnolinguistic characteristics of studied Uralic populations. (PDF 15 kb)
Dinuclear metal catalysts for the synthesis of oxygenated polymers
Creators: name: Saini, Prabhjot Kaur
Publisher: name: Imperial College London
Year: 2014

description: This thesis describes the synthesis of heterodinuclear and homodinuclear catalysts and the in depth investigations carried out when using these catalysts for the ring opening copolymerisation of epoxide/CO2 or epoxide/anhydride to generate polycarbonates or polyesters, respectively. Chapter 2 reports the kinetic and mechanistic studies carried out for cyclohexene oxide/CO2 copolymerisation reactions. Several di-magnesium catalysts bearing a symmetrical N4O2 macrocyclic ligand and different co-ligands (acetate, trifluoroacetate, benzoate, aryl oxide and bromide) were explored. These investigations revealed that both metal centres of the catalyst are involved in the copolymerisation reaction and that the rate determining step is likely to be the carbonate attack on the metal bound epoxide. CO2 insertion is relatively fast. Additionally, there seems to be a co-ligand effect on the rate of copolymerisation, with an optimum activity observed with the acetate co-ligand. These findings support the hypothesis that one co-ligand remains bound to the catalyst during copolymerisation reactions. Chapter 3 describes the synthesis of a Zn-Mg heterodinuclear catalyst, albeit as a mixture with di-zinc and di-magnesium catalysts. However, this mixed catalyst system has an improved activity in cyclohexene oxide or propylene oxide/CO2 copolymerisation reactions, compared to the di-zinc and di-magnesium counterparts alone or in combination. This suggests that the heterodinuclear catalyst promotes the enhanced activity observed with the mixed catalyst system. Furthermore, this mixed catalyst system has enabled the selective formation of α,ω-di-hydroxyl end-capped polycarbonate chains, which can be used in polyurethane synthesis. Additionally, two asymmetrical di-zinc complexes and an asymmetrical Zn-Mg complex have been synthesised and fully characterised. Chapter 4 shows that the di-magnesium and di-zinc catalysts previously reported by our group, for epoxide/CO2 copolymerisations, are also active in cyclohexene oxide/phthalic anhydride copolymerisation reactions. The di-magnesium catalyst is four times faster than the di-zinc derivative. These homodinuclear catalysts were used in terpolymerisation reactions of epoxide/anhydride/CO2, to form block copoly(ester-carbonates), which have significantly higher Tg values (˃ 90 °C) compared to polyester and polycarbonate chains (˂ 85 °C).
Strategy Logic with Imperfect Information
Creators: name: Berthon, Raphaël
name: Maubert, Bastien
name: Murano, Aniello
name: Rubin, Sasha
name: Vardi, Moshe
Publisher: name: arXiv
Year: 2018
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We introduce an extension of Strategy Logic for the imperfect-information setting, called SLii, and study its model-checking problem. As this logic naturally captures multi-player games with imperfect information, the problem turns out to be undecidable. We introduce a syntactical class of "hierarchical instances" for which, intuitively, as one goes down the syntactic tree of the formula, strategy quantifications are concerned with finer observations of the model. We prove that model-checking SLii restricted to hierarchical instances is decidable. This result, because it allows for complex patterns of existential and universal quantification on strategies, greatly generalises previous ones, such as decidability of multi-player games with imperfect information and hierarchical observations, and decidability of distributed synthesis for hierarchical systems. To establish the decidability result, we introduce and study QCTL*ii, an extension of QCTL* (itself an extension of CTL* with second-order quantification over atomic propositions) by parameterising its quantifiers with observations. The simple syntax of QCTL* ii allows us to provide a conceptually neat reduction of SLii to QCTL*ii that separates concerns, allowing one to forget about strategies and players and focus solely on second-order quantification. While the model-checking problem of QCTL*ii is, in general, undecidable, we identify a syntactic fragment of hierarchical formulas and prove, using an automata-theoretic approach, that it is decidable. The decidability result for SLii follows since the reduction maps hierarchical instances of SLii to hierarchical formulas of QCTL*ii .
A Wavelet Space-Scale-Decomposition Analysis of Structure and Evolution fo QSO's Ly$α$ Absorption Lines
Creators: name: Pando, Jesus
name: Fang, Li-Zhi
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A wavelet space-scale decomposition (SSD) analysis of large scale structures in the universe has been developed. The SSD method of identifying and measuring structures in the spatial distribution of objects has been demonstrated. The position and strength (richness) of the identified clusters can be described by the corresponding coefficient of the wavelet transform. Using this technique, we systematically detected the clustering and its evolution of QSO's Ly$α$ forest lines in real data and simulated samples. We showed that the clusters of Ly$α$ absorbers do exist on scales as large as at least 20 h$^{-1}$ Mpc at significance levels of 2-4 $σ$. Independent data sets show about the same strength distribution of the decomposed clusters. The number densities of the clusters on scales of 10 - 20 h$^{-1}$ Mpc are found to evolve in an opposite sense as that of the lines themselves, i.e. they decrease with redshift. We also showed that the number density and the strength distribution of clusters can play an important role in testing or discriminating models, i.e. it can distinguish real data and simulated samples, which cannot be discriminated by traditional ways. We used Daubechies 4 and Mallat wavelets as the bases of the SSD. All above-mentioned conclusions do not depend on either wavelet basis.
description: LaTeX 25 pages + 11 PostScript figures
Eigensolutions and spectral analysis of a model for vertical gene transfer of plasmids
Creators: name: Stadler, Eva
Publisher: name: arXiv
Year: 2018
Subjects: subject: Analysis of PDEs (math.AP)
subject: Spectral Theory (math.SP)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Mathematics
subject: FOS: Biological sciences
subject: 92D25, 35L02, 35Q92, 47A10, 47B65

description: Plasmids are autonomously replicating genetic elements in bacteria. At cell division plasmids are distributed among the two daughter cells. This gene transfer from one generation to the next is called vertical gene transfer. We study the dynamics of a bacterial population carrying plasmids and are in particular interested in the long-time distribution of plasmids. Starting with a model for a bacterial population structured by the discrete number of plasmids, we proceed to the continuum limit in order to derive a continuous model. The model incorporates plasmid reproduction, division and death of bacteria, and distribution of plasmids at cell division. It is a hyperbolic integro-differential equation and a so-called growth-fragmentation-death model. As we are interested in the long-time distribution of plasmids we study the associated eigenproblem and show existence of eigensolutions. The stability of this solution is studied by analyzing the spectrum of the integro-differential operator given by the eigenproblem. By relating the spectrum with the spectrum of an integral operator we find a simple real dominating eigenvalue with a non-negative corresponding eigenfunction. Moreover, we describe an iterative method for the numerical construction of the eigenfunction.
title: 01_2138
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Moral inquiry : we're all in this together
Creators: name: Küspert, Nick
Publisher: name: The University of St Andrews
Year: 2024
Subjects: subject: Moral epistemology
subject: Social epistemology
subject: Moral testimony
subject: Testimony
subject: Moral experts
subject: Moral understanding
subject: Moral knowledge
subject: Identity
subject: Blame
subject: BJ1411.K8
subject: Knowledge, Theory of
subject: Ethics
subject: Right and wrong

description: Moral inquiry is often thought of as an individualistic enterprise. This is in large part because morality not only seems to require doing the right thing, but being in touch with moral reality in the right way: to act well, it is necessary to ground our actions on an insight into moral reasons—reasons we can only understand when we inquire for ourselves. In this dissertation, I defend a picture of moral inquiry according to which such inquiry is fundamentally social: we are not alone when it comes to making moral decisions. In particular, I argue that the conception of moral inquiry as an individualistic enterprise wrongly delegitimises a central resource of moral inquiry, moral testimony. To this end, I first argue that moral agreement is of crucial justificatory value in moral inquiry. I then go on to address some worries connected to moral testimony, arguing that reliance on moral testimony is not intrinsically wrong and indeed oftentimes permissible if not required of us. I complement this with a discussion of moral expertise, arguing that the search for moral experts has often been too focused on theoretical knowledge. However, practical experience is a much more reliable way of identifying those we can rely on with respect to a particular moral issue. Lastly, I discuss one consequence this more social picture of moral inquiry has, namely that blame can not only be allocated to a wrongdoing agent, but also to those who guided the agent to that act. This concludes my contribution to the defence of a more social picture of moral inquiry. Overall, however, my aim is not to do away with the importance of being rightly connected to moral reality—it is just that the best connection to moral reality available is often not through ourselves, but through others.
Progress towards a source of cold, slow molecules for tests of fundamental physics
Creators: name: Bumby, James
Publisher: name: Imperial College London
Year: 2017

description: This thesis reports on two beam sources of ytterbium fluoride (YbF), and assesses their viability for use in precision measurements of the electron electric dipole moment. The first source is a single-stage cryogenic buffer-gas source optimised for high extraction efficiency and low forward velocity. The thermalisation of the YbF rotational and translational temperatures with the buffer gas were measured through laser-induced fluorescence spectroscopy of molecules within the beam. The velocity distributions and fluxes of beams produced by this source were measured for buffer gas flow rates between 10 and 40 SCCM. We found that the mean beam velocities were between 190 and 210 m/s, and characteristic molecular fluxes were of the order 2*10^9 /sr/pulse. The second source is a two-stage cryogenic buffer-gas source, where the first stage is supposed to produce a high flux and the second stage is meant to slow the beam to low velocity. We found optimal behaviour running at lower pressures than the single-stage source, and measured YbF beams with a peak velocity of 70 m/s. Although not fully optimised, the source shows clear evidence of deceleration in the second stage, and drastically outperforms even the best measured fluxes from the single-stage source in terms of molecules with velocities below 100 m/s. The characteristic flux from this second source is of the order 7*10^7 /sr/pulse. As part of our parametrisation procedure, we developed a novel experimental technique to measure velocity distributions in the limit of low signal-to-noise ratios. We optically bleached population from a target hyperfine level of certain Doppler classes within the molecular beam. By integrating over all bleached molecules, we measured the number of YbF molecules with a given velocity. This technique was experimentally implemented, and was found to be in good agreement with results obtained using more traditional measurement schemes.
The Star Studded Stable radio program, circa 1958-1959
Publisher: name: Columbia University
Year: 2020
Subjects: Motion picture producers and directors
Actors
Motion pictures

description: "The Star Studded Stable" is an episode of the "Memoirs of the Movies" series, produced by Group W of the Westinghouse Broadcasting Company in collaboration with Columbia University's Oral History Research Office
Bright Stars and Recent Star Formation in the Irregular Magellanic Galaxy NGC2366
Creators: name: Aparicio, A.
name: Cepa, J.
name: Gallart, C.
name: Castaneda, H.
name: Chiosi, C.
name: Bertelli, G.
name: Munoz-Tunon, C.
name: Telles, Eduardo
name: Tenorio-Tagle, G.
name: Diaz, A. I.
name: Garcia-Vargas, M. L.
name: Garzon, F.
name: Gonzalez-Delgado, R. Ma.
name: Mas-Hesse, M.
name: Perez, E.
name: Rodriguez-Espinosa, J. M.
name: Terlevich, E.
name: Terlevich, R. J.
name: Varela, A. M.
name: Vilchez, J. M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The stellar content of the Im galaxy NGC 2366 is discussed on the basis of CCD BVR photometry. The three brightest blue and red stars have been used to estimate its distance, obtaining a balue of 2.9 Mpc. The spatial distribution of the young stellar population is discussed in the light of the integrated color indices and the color-magnitude diagrams of different zones of the galaxy. A generalized star formation burst seems to have taken place about 50 Myr ago. The youngest stars are preferentially formed in the South-West part of the bar, where the giant HII complex NGC 2363 is located, being younger and bluer. The bar seems to play a role favouring star formation in one of its extremes. Self-propagation however, does not seem to be triggering star formation at large scale. A small region, populated by very young stars has also been found at the East of the galaxy.
description: Astronomical Journal, accepted. This is a uuencoded, compressed, tar file (102 Kbytes) of 1 text, 1 table postscript files. Figures are retrieved as a separate file. One single file with all figures and tables (552Kb) also available from http://www.ast.cam.ac.uk/~etelles/astronomy.html
Additional file 3 of Mobile rehabilitation support versus usual care in patients after total hip or knee arthroplasty: study protocol for a randomised controlled trial
Creators: name: Wang, Qingling
name: Hunter, Sharyn
name: Lee, Regina Lai-Tong
name: Wang, Xiaofeng
name: Chan, Sally Wai-Chi
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Mental Health

description: Additional file 3. Model consent form.
Rudbeckia laciniata Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Rudbeckia
Rudbeckia laciniata

description: Rudbeckia laciniata Linnaeus, Species Plantarum 2: 906. 1753.
"Habitat in Virginia, Canada." RCN: 6550.
Type not designated.
Original material: [icon] in Cornut, Canad. Pl. Hist.: 178, 179. 1635; [icon] in Morison, Pl. Hist. Univ. 3: 22, s. 6, t. 6, f. 53, 54. 1699.
Generitype of Rudbeckia Linnaeus (vide Green, Prop. Brit. Bot.: 183. 1929).
Current name: Rudbeckia laciniata L. (Asteraceae).
Note: Rudbeckia hirta L. was treated as the generitype by Britton & Brown (Ill. Fl. N. U. S., ed. 2, 3: 469. 1913; see McNeill & al. in Taxon 36: 382. 1987). However, under Art. 10.5, Ex. 7 (a voted example) of the Vienna Code, this is a type choice made under the American Code and is to be replaced under Art. 10.5b by Green’s choice (Prop. Brit. Bot.: 183. 1929) of R. laciniata L.
Fernald & Schubert (in Rhodora 50: 171. 1948) referred to a "photograph of the TYPE" but did not indicate which of the possible collections in London (Clifford, Clayton or LINN) it might be. Jarvis & al. (Regnum Veg. 127: 83. 1993) erroneously attributed typification to Fernald & Schubert.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 802, DOI: 10.5281/zenodo.291971
Multivariate Alexander colorings
Creators: name: Traldi, Lorenzo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25

description: We extend the notion of link colorings with values in an Alexander quandle to link colorings with values in a module $M$ over the Laurent polynomial ring $Λ_μ=\mathbb{Z}[t_1^{\pm1},\dots,t_μ^{\pm1}]$. If $D$ is a diagram of a link $L$ with $μ$ components, then the colorings of $D$ with values in $M$ form a $Λ_μ$-module $\mathrm{Color}_A(D,M)$. Extending a result of Inoue [Kodai Math.\ J.\ 33 (2010), 116-122], we show that $\mathrm{Color}_A(D,M)$ is isomorphic to the module of $Λ_μ$-linear maps from the Alexander module of $L$ to $M$. In particular, suppose $M$ is a field and $φ:Λ_μ \to M$ is a homomorphism of rings with unity. Then $φ$ defines a $Λ_μ$-module structure on $M$, which we denote $M_φ$. We show that the dimension of $\mathrm{Color}_A(D,M_φ)$ as a vector space over $M$ is determined by the images under $φ$ of the elementary ideals of $L$. This result applies in the special case of Fox tricolorings, which correspond to $M=GF(3)$ and $φ(t_i) \equiv-1$. Examples show that even in this special case, the higher Alexander polynomials do not suffice to determine $|\mathrm{Color}_A(D,M_φ)|$; this observation corrects erroneous statements of Inoue [J. Knot Theory Ramifications 10 (2001), 813-821; op. cit.].
description: v1: 11 pages, 3 figures. v2: 13 pages, 4 figures. v3: 13 pages, 4 figures. v4: 14 pages, 4 figures. Further changes may be made before publication in the Journal of Knot Theory and its Ramifications
The development of a pulse-optimized flow control method for turbocharger turbine performance improvement
Creators: name: Cao, Kun
Publisher: name: Imperial College London
Year: 2017

description: A new turbocharger turbine concept that enhances exhaust energy recovery has been developed; it is known as the ‘rotating vane turbine’ (RVT). It aims to address the negative impact of the pulsating exhaust flow on the turbocharger turbine, so that the exhaust energy can be recovered more efficiently compared to the state of art turbocharging technologies. Different from traditional turbine configurations, in which the nozzle is stationary, the RVT incorporates a rotating nozzle ring at a relatively low speed. It thus minimises the deviation of the turbine incidence angle from the optimal design angle on average through a pulse cycle, it as such leads to an improvement of turbine performance. Two control methods are investigated for the rotating nozzle: a passive self-rotation and one that is controlled from the outside with the use of an external driving turbine. The geometry of the rotating nozzle ring is also optimized to reduce the incidence loss on the nozzle blade under unsteady flow. The new RVT is studied through numerical calculation in order to demonstrate that the rotating nozzle ring can adaptively change the flow angle at the turbine inlet through a pulse cycle. As a result, the turbine operating point is pushed to better performance region with higher turbine efficiency and lower pressure ratio, compared to a traditional stationary nozzle ring. The flow analysis shows that the turbine performance improvement is due to the reduction of the flow separation on the turbine blade under sub-optimal operating conditions. Detailed experimental testing is also carried out to further validate the new concept. Two rotating nozzles with different angles are tested under different flow frequencies, turbine speeds, turbine loads and mass flow rates. As comparisons, stationary vane turbine (SVT) and nozzleless turbine are also tested under the same operating conditions as for RVT. The testing results demonstrate that, the rotating nozzle ring can reduce the amplitude of the flow pulses, thereby reducing the unsteadiness level of the turbine operation. Similar to the simulation results, a significant increase in average turbine efficiency as well as a reduction of turbine pressure ratio are observed for RVT, compared to for SVT or nozzleless turbine. A preliminary study of 1D engine simulation is also carried out to investigate the impact of the new RVT on the engine performance. The simulation results show that, the back pressure of the engine with RVT is reduced based on the same engine power output. This indicates the new RVT can effectively reduce the BSFC of an engine, compared to a traditional SVT.
title: Foi et hommage de Geoffroy de Beauvoir à Antoine de Saigny - Archives départementales de la Côte-d'Or, E 34 ter
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: LaMOP
subject: Laboratoire de médiévistique occidentale de Paris

description: Foi et hommage de Geoffroy de Beauvoir à Antoine de Saigny
Document transcrit dans le cadre des ateliers de paléographie du Chancelier Rolin des Archives départements des Côtes d’Or
description: Source: https://archives.cotedor.fr/v2/site/AD21/web/media/04_apprendre/02_ateliers_chancelier_rolin/paleographie/debutants/2011_2012/document_03.pdf
description: Source: https://www.nakala.fr/10.34847/nkl.ea1e79c7
description: Foi et hommage de Geoffroy de Beauvoir à Antoine de Saigny - Archives départementales de la Côte-d'Or, E 34 ter
Metabolomic studies of amyotrophic lateral sclerosis
Creators: name: Valbuena, Gabriel
Publisher: name: Imperial College London
Year: 2015

description: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive neurodegenerative disease, and is fatal within 3-5 years of onset. Metabolic dysfunctions have consistently been identified in ALS, although its role in pathogenesis remains unclear. In this thesis, I apply a metabolomic approach using 1H NMR spectroscopy and Gas Chromatography-Mass Spectrometry in a range of disease models of increasing biological complexity, as well as patient tissues, in order to reveal perturbations to the metabolic network that may impact the course of the disease. I examined alterations to metabolism in the motor neuron-like NSC-34 cell line, and found that mutant SOD1 led to increased glycolysis to divert glucose from oxidative metabolism, and a broad intracellular amino acid depletion. The contribution of non-cell autonomous processes were also investigated in an astrocyte-motor neuron co-culture model, where mutant SOD1 produced varying perturbations to glycolysis and oxidative stress responses in each cell type, together with decreased branched-chain amino acid catabolism and glutamine-glutamate production that may indicate impaired neurotransmitter recycling. I also found different metabolic responses to mutant SOD1 in two strains with varying rates of disease progression, suggesting a role for early metabolic responses to mutant SOD1 in affecting the course of disease. In addition, I identify a metabolic signature for C9ORF72 ALS in cerebellum tissue, providing evidence that the hexanucleotide repeat expansion leads to distinctive metabolic changes in the CNS. Overall, I demonstrate the applicability of metabolomics in ALS research, particularly in revealing hidden metabolic subtypes of the disease. This opens opportunities to improve our understanding of the processes leading to motor neuron death in ALS, and highlights the potential use of metabolomics as a tool to develop therapies targeted to the individual metabolic responses of individuals susceptible to ALS.