cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Photo plot of Sonderend, Waboomberg, Langeberg, site 3320CA/2
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Photo plot
Sonderend
Langeberg
Waboomberg

description: This is a scanned copy of a photo plot of Sonderend, Waboomberg, Langeberg, site 3320CA/2. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Electron-Magnon Scattering in Magnetic Heterostructures Far Out-of-Equilibrium
Creators: name: Tveten, Erlend G.
name: Brataas, Arne
name: Tserkovnyak, Yaroslav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theory of out-of-equilibrium ultrafast spin dynamics in magnetic heterostructures based on the s-d model of ferromagnetism. Both in the bulk and across interfaces, the exchange processes between the itinerant s and the localized d electrons are described by kinetic rate equations for electron-magnon spin-flop scattering. The principal channel for dissipation of angular momentum is provided by spin relaxation of the itinerant electrons. Our theory extends interfacial spin phenomena such as torques, pumping, and the Peltier and Seebeck effects to address laser-induced rapid spin dynamics, in which the effective electron temperature may approach or even exceed the Curie temperature.
description: 4 pages, 3 figures
Genomic features of bacterial adaptation to plants
Creators: name: Lebeis, Sarah
name: Rangel Alvarez, Bryan
name: Monteiro, Freddy
name: Woyke, Tanja
name: Clingenpeel, Scott
name: Venturi, Vittorio
name: McDonald, Meredith
name: Herrera Paredes, Sur
name: Wang, Kunru
name: Miao, Jiamin
name: Dangl, Jeffery L.
name: Levy, Asaf
name: Klein, Andrew P.
name: Pelletier, Dale A.
name: Lu, Tse-Yuan
name: Salas Gonzalez, Isai
name: Vorholt, Julia A.
name: Stillman, Kyra
name: Ley, Ruth E.
name: Jin, Zhao
name: Devescovi, Giulia
name: Tringe, Susannah G.
name: Lundberg, Derek S.
name: Zhao, Bingyu
name: Feltcher, Meghan E.
name: Mittelviefhaus, Maximilian
name: Doty, Sharon L.
name: Rio, Tijana Glavina
name: Grant, Sarah R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Author(s): Levy, A; Salas Gonzalez, I; Mittelviefhaus, M; Clingenpeel, S; Herrera Paredes, S; Miao, J; Wang, K; Devescovi, G; Stillman, K; Monteiro, F; Rangel Alvarez, B; Lundberg, DS; Lu, TY; Lebeis, S; Jin, Z; McDonald, M; Klein, AP; Feltcher, ME; Rio, TG; Grant, SR; Doty, SL; Ley, RE; Zhao, B; Venturi, V; Pelletier, DA; Vorholt, JA; Tringe, SG; Woyke, T; Dangl, JL | Abstract: © 2017 The Author(s). Plants intimately associate with diverse bacteria. Plant-associated bacteria have ostensibly evolved genes that enable them to adapt to plant environments. However, the identities of such genes are mostly unknown, and their functions are poorly characterized. We sequenced 484 genomes of bacterial isolates from roots of Brassicaceae, poplar, and maize. We then compared 3,837 bacterial genomes to identify thousands of plant-associated gene clusters. Genomes of plant-associated bacteria encode more carbohydrate metabolism functions and fewer mobile elements than related non-plant-associated genomes do. We experimentally validated candidates from two sets of plant-associated genes: one involved in plant colonization, and the other serving in microbe-microbe competition between plant-associated bacteria. We also identified 64 plant-associated protein domains that potentially mimic plant domains; some are shared with plant-associated fungi and oomycetes. This work expands the genome-based understanding of plant-microbe interactions and provides potential leads for efficient and sustainable agriculture through microbiome engineering.
title: Use of wood in construction
Creators: name: Dickens, H. B.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1967
Subjects: subject: wood (material)
subject: bois (matériau)
subject: lumber
subject: bois de construction

description: Information is provided on reference manuals of use in current Canadian wood design practice. Other topics include: the classification of lumber, grade marking, design stresses, glue laminated construction, and lumber for residential construction.
title: How native-Chinese speakers establish discourse-level mental representations of English-language academic texts: A mixed method study
Creators: name: Wagstaffe, James Patrick
Publisher: name: University of Reading
Year: 2022

description: This thesis reports on a mixed methods study which investigated the ability of native-Chinese speaking readers of academic English to identify incongruent words in coreferential noun phrases, as well as the extent to which such an ability may vary as a function of reading proficiency. Additionally, the study also explored the extent to which the presence or absence of a grammatical determiner (e.g. this/these) may contribute towards such an ability. The study was composed of two major elements: an eye-tracking experiment and follow up think-aloud interviews. Reading proficiency was measured according to the participants’ IELTS scores. In addition, individual differences, in terms of vocabulary knowledge, grammar knowledge and working memory capacity were explored in relation to the participants’ ability to detect the incongruencies. The results of the study suggest that the ability to detect an incongruent word in a text depends primarily on the reader being able to establish a situation model mental representation of that text. Furthermore, the results also suggest that this ability is chiefly, although not entirely, confined to upper-intermediate or advanced-level readers. While the measures of individual differences used in this study did not significantly predict for the ability to identify the incongruent words in the text, analysis of the transcripts from the think-aloud interviews found that the main impediment to the formation of situation model representations of academic text was difficulty with linguistic processing. The implications of these findings are discussed in relation to both the practice and theory of second language reading pedagogy. In terms of practice, the implications include (i) the need to develop metacognitive strategy training designed to help L2 readers establish situation model representations of the texts they read; (ii) the need for specific instruction on the grammatical construction and cohesive function of complex coreferential noun phrases in academic writing; (iii) the potential for using anomaly detection as a tool for measuring L2 reading comprehension; (iv) the need for university managers to provide teaching staff with training on how to help L2 readers establish situation model representations of the texts they read. With regards to theory, the results ix of the study lend weight to Walter’s (2007) suggestion that L2 reading should be understood more in terms of accessing fundamental cognitive processes through the L2, than of a transference of pre�existing reading skills from the L1 to the L2
Line intercept at Constantiaberg FM tower Cape Peninsula in Tokai, Cape Peninsula, site 3418AB/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Cape Peninsula
Constantiaberg
Tokai

description: This is a scanned copy of a document of a line intercept at Constantiaberg FM tower Cape Peninsula in Tokai, Cape Peninsula, site 3418AB/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Non-equilibrium behavior of the magnetization in the helimagnetic phases of the rare earth alloys R_{1-x}Y_{x} (R = Gd, Tb, Dy)
Creators: name: Yamazaki, Teruo
name: Ishiyama, Junno
name: Noya, Yosuke
name: Kurihara, Mai
name: Yaguchi, Hiroshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have performed DC and AC magnetization measurements for the rare-earth magnetic alloy systems Gd_{0.62}Y_{0.38}, Tb_{0.86}Y_{0.14}, and Dy_{0.97}Y_{0.03}. These materials commonly exhibit a proper helical magnetic structure, and ferromagnetic structure at lower temperatures.In all of these materials, a difference between zero-field-cooled (ZFC) magnetization and field-cooled (FC) magnetization and a hysteresis loop in the M-H curve have been observed in the helimagnetic phases. The non-equilibrium behavior is possibly caused by a common nature, e. g., chiral domain structures. In addition to the above behavior, strong non-linearity of the magnetization and slow spin dynamics have been observed around the N'eel temperature only in Gd$_{0.62}$Y$_{0.38}$. The spin-glass like behavior observed in Gd_{0.62}Y_{0.38} could be related to a novel glassy state such as a helical-glass state.
description: 7pages 4 figures, 20th International Conference on Magnetism (ICM2015)
NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth
Creators: name: Chen, Liang
name: Koenigsknecht, Mark J.
name: Matsushima, Glenn K.
name: Montgomery, Stephanie A.
name: Plevy, Scott E.
name: Maharshak, Nitsan
name: Chou, Wei-Chun
name: Wilson, Justin E.
name: Brickey, W June
name: Ting, Jenny P.-Y.
name: Truax, Agnieszka D.
name: Sartor, R Balfour
name: Packey, Christopher D.
name: Young, Vincent B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Inflammatory bowel diseases involve the dynamic interplay of host genetics, microbiome and inflammatory response. Here, we report that NLRP12, a negative regulator of innate immunity, is reduced in human ulcerative colitis by comparing monozygotic twins and other patient cohorts. In parallel, Nlrp12-deficiency in mice caused increased colonic basal inflammation, leading to a less-diverse microbiome, loss of protective gut commensal strains (Lachnospiraceae) and increased colitogenic strains (Erysipelotrichaceae). Dysbiosis and colitis susceptibility associated with Nlrp12-deficency were reversed equally by treatment with antibodies targeting inflammatory cytokines or by administration of beneficial commensal Lachnospiraceae isolates. Fecal transplants from specific pathogen free reared mice into germ-free Nlrp12-deficient mice showed that NLRP12 and the microbiome each contribute to immune signaling that culminates in colon inflammation. These findings reveal a feed-forward loop where NLRP12 promotes specific commensals that can reverse gut inflammation, while cytokine blockade during NLRP12-deficiency can reverse dysbiosis.
title: The Influence of Student Identities on Progression to, through and beyond Higher Education
Creators: name: Hamilton, Claire
Publisher: name: University of Liverpool Repository
Year: 2021

description: Increasing opportunities for higher education in the Middle East has meant that many women who would not traditionally have attended post-secondary education are now encouraged to access higher education. This change has come with many potential problems as the traditional role of women in a conservative society is redefined. It is a change which is embraced by some and challenged by others and it presents potential problems for higher education institutions. This thesis is a case-based life history study examining the experiences of young female students from different economic and socio-cultural backgrounds in one higher education institution in a Middle Eastern country. The aims of the study are to research and document the factors that shape the identities of female students, to develop a clearer understanding of how those identifies influence their experience of higher education and to suggest evidence-based ways of enhancing those experiences. A sample of ten students took part in a series of detailed interviews, recounting their past and present learning experiences and their future aspirations. Their life stories were used to build their life histories and to describe their evolving student identities, including the dominant factors informing their experiences and opportunities. Bourdieu’s concept of capital was used to analyse the data and to examine the three main factors that emerged in the development of their identities: how the students define their roles and identities within their family; how (and who) they recognize as individuals of influence; and how they identify individual and collective moments of realization. The findings are discussed in the context of the past, present and future to determine how their student identities are shaped and how the students are able to shape them. This generates a better understanding of their experiences and opportunities as they progress to, through and beyond higher education. The results of the research will be used to inform policy and practice at this specific institution and so potentially contribute to the enhancement of the higher education experiences of women in the region.
A diffusion-based approach to obtaining the borders of urban areas
Creators: name: Comin, Cesar Henrique
name: Silva, Filipi Nascimento
name: Costa, Luciano da Fontoura
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: The access to an ever increasing amount of information in the modern world gave rise to the development of many quantitative indicators about urban regions in the globe. Therefore, there is a growing need for a precise definition of how to delimit urban regions, so as to allow proper respective characterization and modeling. Here we present a straightforward methodology to automatically detect urban region borders around a single seed point. The method is based on a diffusion process having street crossings and terminations as source points. We exemplify the potential of the methodology by characterizing the geometry and topology of 21 urban regions obtained from 8 distinct countries. The geometry is studied by employing the lacunarity measurement, which is associated to the regularity of holes contained in a pattern. The topology is analyzed by associating the betweenness centrality of the streets with their respective class, such as motorway or residential, obtained from a database.
title: Synchronous bilateral benign ovarian neoplasms
Creators: name: Brar, Anmol
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Genital (female) imaging
subject: Genital / Reproductive system female
subject: MR
subject: Imaging sequences
subject: Neoplasia
subject: Clinical Cases

description: Clinical History: A 45-year-old female patient (para 2 live 2) was referred to the Department of Gynaecology with non-specific complaints of pain in the abdomen on and off for 1 year, which was relieved by taking medication. Menstrual history was insignificant.

An ultrasonography (USG) report of the whole abdomen, which was done outside at a primary diagnostic centre, revealed a multi-loculated complex cystic lesion measuring 5.8 x 5.0 cm in the right adnexa, showing thin and thick internal septations, a few of which showed mild vascularity on colour Doppler, raising suspicion of a neoplastic aetiology of right ovarian origin. The right ovary was not seen separately or distinctly from the above-mentioned lesion.

However, USG suggested normal size and position of the left ovary. No obvious left adnexal mass was noted. The rest of the ultrasound findings revealed no other significant abnormalities.

Therefore, in view of USG findings, the patient was referred to the Radiology department for further evaluation by Magnetic Resonance Imaging (MRI) of the pelvis. CA-125 serum marker was also advised to rule out malignant pathology.

description: 45 years, female
title: AN ASSESSMENT OF THE EXTENT OF ICT INTEGRATION IN FOUR ZAMBIAN UNIVERSITIES AND ITS IMPACT ON QUALITY ENHANCEMENT IN THE TEACHING AND LEARNING PROCESS
Creators: name: Akapelwa, Gertrude
Publisher: name: University of Liverpool Repository
Year: 2020

description: The high demand for higher education (HE) in Zambia created by the increased youthful population, alongside the deteriorating HE infrastructure and learning facilities due to reduced budgets, obliges Zambia to turn to ICT integration to improve teaching and learning. This research determined the extent of ICT integration in four Zambian universities and its effect on enhancing pedagogy. The study explored the ICT investments trends in Higher Education Institutions (HEIs) between 2011 and 2013; it determined the ICT technology installed; whether lecturers use ICTs in teaching and learning; and identified the lecturers’ ICT knowledge and skills and any enablers and barriers to ICT usage. The research used case study method: questionnaires, interviews and documentation from the HEIs websites. Population data was gathered from a sample of faculty and senior administrators, policy and HEIs strategic documents. The results show that: ICT investment greatly increased during the period; the national policy, regulatory framework and institutional strategies to support ICT integration exist; and there are sufficient hardware devices, communication infrastructure and adequate software. The lecturers’ interests, attitudes, perceptions and beliefs are conducive to technology adoption. However, no ICT implementation framework was found in any of the universities. The majority of lecturers mainly used standard software and the internet, while a few used software that supports teaching and learning. This was due to lecturers’ unawareness of the existence of ICTs that support pedagogy, lack of training in instructional technology, and the non-existence of learning technologists to support the lecturers in integrating ICTs in pedagogy. The research recommends establishing ICT implementation targets; employing learning technologists, increasing lecturer ICT awareness and skills; equipping ICT learning facilities; linking learning environment to facilitate learning anywhere and anytime; promoting remote content access and local content development; and promoting ICT supported learning in conformity with the principles of best practice in higher education learning. The results from the research inform policy makers, HEI leaders and HE technologists.
Advancing the understanding of autism disease mechanisms through genetics
Creators: name: De La Torre-Ubieta, Luis
name: Geschwind, Daniel H.
name: Stein, Jason L
name: Won, Hyejung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled remarkable advances in our understanding of its potential neurobiological mechanisms. Yet, at the same time, these findings highlight extraordinary causal diversity and complexity at many levels ranging from molecules to circuits and emphasize the gaps in our current knowledge. Here we review current understanding of the genetic architecture of ASD and integrate genetic evidence, neuropathology and studies in model systems with how they inform mechanistic models of ASD pathophysiology. Despite the challenges, these advances provide a solid foundation for the development of rational, targeted molecular therapies.
Heterointerface potentials in the effective-mass approximation for wurtzite semiconductor structures
Creators: name: Takhtamirov, Eduard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In the effective-mass approximation, the step-like crystal potential of a wurtzite semiconductor heterostucture should be supplemented by Dirac delta-function heterointerface terms. They stem from the difference in the Bloch functions of the semiconductors and remain finite even for structures with graded chemical composition, where the terms are presented by a smeared Dirac delta function. We find these heterointerface potentials by employing the k*p method, and evaluate their strength from band-structure parameters of bulk materials. These potentials are weak for semiconductors compliant with the cubic approximation, which forces the zinc-blende crystal symmetry upon the wurtzite lattice. Nevertheless, they can produce a noteworthy effect due to a strong built-in electric field usually present in wurtzite heterostructures. We estimate that for GaN/AlN [0001] heterojunctions their net contributions to the energy of conduction and valence band states are 3 meV and 10 meV, respectively. The presence of the interface potential can modify the shape of the valence-band spectrum calculated without the potential.
title: Building on fill
Creators: name: Legget, R. F.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1967
Subjects: subject: Basements and foundations
valueUri: urn:ircsubjects:IRC0320
subject: Sous-sol et fondations
valueUri: urn:ircsubjects:IRC0320
subject: fills (materials)
subject: matériel de remblai
subject: foundations
subject: fondation (ouvrage)
subject: waste disposal
subject: décharge des ordures
subject: site analysis
subject: analyse du site

description: Precautions to be taken and recommended practice are discussed in a general way. The article emphasizes that building on filled sites, where the filling operation has been carefully controlled, can be and has been successful.
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
Creators: name: Qi, Jun
name: Bradner, James E
name: Xiong, Jessie
name: Parker, Joel S
name: Souroullas, George P
name: Clark, Kelly S
name: Burd, Christin E
name: Fedoriw, Yuri
name: Sharpless, Norman E
name: Paulk, Joshiawa
name: Liu, Jie-Yu
name: Jeck, William R
name: Simon, Jeremy M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic EZH2 gain-of-function mutation (Y646F in human, Y641F in the mouse) can be conditionally expressed. Expression of Ezh2Y641F in mouse B-cells or melanocytes caused high-penetrance lymphoma or melanoma, respectively. Bcl2 overexpression or p53 loss, but not c-Myc overexpression, further accelerated lymphoma progression, and expression of mutant B-Raf but not mutant N-Ras further accelerated melanoma progression. Although expression of Ezh2Y641F increased abundance of global H3K27 trimethylation (H3K27me3), it also caused a widespread redistribution of this repressive mark, including a loss of H3K27me3 associated with increased transcription at many loci. These results suggest that Ezh2Y641F induces lymphoma and melanoma through a vast reorganization of chromatin structure inducing both repression and activation of polycomb-regulated loci.
Gradual Certified Programming in Coq
Creators: name: Tanter, Éric
name: Tabareau, Nicolas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.3.3, F.3.1

description: Expressive static typing disciplines are a powerful way to achieve high-quality software. However, the adoption cost of such techniques should not be under-estimated. Just like gradual typing allows for a smooth transition from dynamically-typed to statically-typed programs, it seems desirable to support a gradual path to certified programming. We explore gradual certified programming in Coq, providing the possibility to postpone the proofs of selected properties, and to check "at runtime" whether the properties actually hold. Casts can be integrated with the implicit coercion mechanism of Coq to support implicit cast insertion a la gradual typing. Additionally, when extracting Coq functions to mainstream languages, our encoding of casts supports lifting assumed properties into runtime checks. Much to our surprise, it is not necessary to extend Coq in any way to support gradual certified programming. A simple mix of type classes and axioms makes it possible to bring gradual certified programming to Coq in a straightforward manner.
description: DLS'15 final version, Proceedings of the ACM Dynamic Languages Symposium (DLS 2015)
title: Some implications of the properties of wood
Creators: name: Hutcheon, N. B.
name: Jenkins, J. H.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1967
Subjects: subject: wood (materials)
subject: bois (matériau)
subject: strength of materials
subject: résistance des matériaux
subject: beams
subject: poutre
subject: shear stresses
subject: contrainte de cisaillement
subject: dimensional stability
subject: stabilité dimensionelle
subject: moisture content
subject: degré hygrométrique
subject: durability
subject: durabilité

description: The directional strength and moisture response properties, moisture changes in service, processed forms of wood, and durability are discussed in relation to the ways in which wood can best be used in building.
Supplementary documentation for SAEON's field instrument data collected at the Cathedral Peak CAT6 #1 station
Creators: name: South African Environmental Observation Network (SAEON) Grasslands-Forests-Wetlands Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Cathedral Peak
Hydrological
Soil Diviner tube
Soil water content

description: This package contains supporting information for the hydrological data collected at Cathedral Peak's CAT6 #1 station, as part of the South African Environmental Observation Network's monitoring projects.
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Creators: name: Campisi, Judith
name: Meng, Aimin
name: Chang, Jianhui
name: Shao, Lijian
name: Feng, Wei
name: Luo, Yi
name: Ponnappan, Usha
name: Wang, Xiaoyan
name: Aykin-Burns, Nukhet
name: Hauer-Jensen, Martin
name: Laberge, Remi-Martin
name: Janakiraman, Krishnamurthy
name: Wang, Yingying
name: Zhou, Daohong
name: Sharpless, Norman E.
name: Krager, Kimberly
name: Demaria, Marco
name: Ding, Sheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)1–6. Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders7, suggesting that SCs play a causative role in certain age-related pathologies. Thus, a ‘senolytic’ pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span. To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type– and species-independent manner by inducing apoptosis. Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs). Notably, this depletion mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and MuSCs in normally aged mice. Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells. Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents.
Estimating the Number Of Roots of Trinomials over Finite Fields
Creators: name: Kelley, Zander
name: Owen, Sean
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We show that univariate trinomials $x^n + ax^s + b \in \mathbb{F}_q[x]$ can have at most $δ\Big\lfloor \frac{1}{2} +\sqrt{\frac{q-1}δ} \Big\rfloor$ distinct roots in $\mathbb{F}_q$, where $δ= \gcd(n, s, q - 1)$. We also derive explicit trinomials having $\sqrt{q}$ roots in $\mathbb{F}_q$ when $q$ is square and $δ=1$, thus showing that our bound is tight for an infinite family of finite fields and trinomials. Furthermore, we present the results of a large-scale computation which suggest that an $O(δ\log q)$ upper bound may be possible for the special case where $q$ is prime. Finally, we give a conjecture (along with some accompanying computational and theoretical support) that, if true, would imply such a bound.
Visualizing revivals and fractional revivals in a Kerr medium using optical tomogram
Creators: name: Rohith, M.
name: Sudheesh, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically study the optical tomography of the time evolved states generated by the evolution of different kinds of initial wave packets in a Kerr medium. Exact analytical expression for the optical tomogram of the quantum state at any instant during the evolution of a generic initial wave packet is derived in terms of Hermite polynomials. Time evolution of the optical tomogram is discussed for three kinds of initial states: a coherent state, an $m$-photon-added coherent state, and even and odd coherent states. We show the manifestation of revival and fractional revivals in the optical tomograms of the time evolved states. We find that the optical tomogram of the time evolved state at the instants of fractional revivals shows structures with sinusoidal strands. The number of sinusoidal strands in the optical tomogram of the time evolved state at $l$-sub-packet fractional revivals is $l$ times the number of sinusoidal strands present in the optical tomogram of the initial state. We have also investigated the effect of decoherence on the optical tomograms of the states at the instants of fractional revivals for the initial states considered above. We consider amplitude decay and phase damping models of decoherence, and show the direct manifestations of decoherence in the optical tomogram.
description: 20 pages, 4 figures
title: Information Warfare: Technology and the Information Advantage
Creators: name: Parker, Daniel Matthew
Publisher: name: Old Dominion University Libraries
Year: 1996

description: This thesis analyzes information warfare--that emerging form of warfare that attempts to destroy, degrade and exploit the information systems of another, while protecting one's own--in the context of the technology of warfare. Just as one might peel an onion, the analysis proceeds from a general analysis of technology in warfare to the more specific analysis of information warfare as it is currently defined. Information technology is an enabling factor in the emergence of information warfare as a new warfare area. Although it is revolutionizing the way warfare is conducted, the elements of information warfare have been practiced for thousands of years. Information warfare itself appears to be a natural and expected evolution in warfare. Throughout history, though, the technological superiority and excellence of one group have been short-lived. Technology tends to proliferate and balance the weapons available. More importantly, superior organization, training and doctrine often overcome superior technology.

The paper concludes that the nature of warfare is changing radically. The information advantage and its ability to reduce the uncertainty in warfare will play an ever important role. Since this advantage is just as important prior to hostilities, the reduction in uncertainty for both political and military actions will be affected. Heightened expectations for the role of technology will continue to grow.

The implications are profound. The world environment is finding regional conflict, ethnic violence, and peacemaking the norm for intervention by conventional military forces. This environment presents a tremendous advantage to the asymmetry in the information edge between military forces such as those of the United States and other countries. Yet, this information advantage could be inconsequential against an opponent without a technological base. The challenge will be to develop the technology, along with the organization, training, and doctrine for information warfare that can be applied against the range of threats to our national interests.
International AIDS Society global scientific strategy: towards an HIV cure 2016
Creators: name: Eyal, Nir
name: Cohen, Éric A.
name: Silvestri, Guido
name: Garcia, Laurindo
name: Siliciano, Janet
name: Taylor, Jeffrey
name: Henderson, Gail
name: Kuritzkes, Daniel
name: Walensky, Rochelle
name: Autran, Brigitte
name: Richman, Douglas
name: Wilson, Ira
name: Alter, Galit
name: Mellors, John
name: Persaud, Deborah
name: Lewin, Sharon R.
name: Saez-Cirion, Asier
name: Douek, Daniel
name: Lifson, Jeffrey D.
name: Auerbach, Judith
name: Moodley, Keymanthri
name: Palmer, Sarah
name: Kiem, Hans-Peter
name: Nijhuis, Monique
name: Ott, Melanie
name: McCune, Joseph
name: Zack, Jerome
name: Cannon, Paula
name: Newman, Peter A.
name: Spire, Bruno
name: Behrens, Georg
name: Van Lunzen, Jan
name: Barre-Sinoussi, Françoise
name: Chomont, Nicolas
name: Tucker, Joseph D.
name: Chen, Zhiwei
name: Nsubuga, Moses Supercharger
name: Benkirane, Monsef
name: Ross, Anna Laura
name: Eholié, Serge
name: Lo, Ying-Ru
name: Cavazzana, Marina
name: Corbelli, Giulio Maria
name: Jefferys, Richard
name: Fidler, Sarah
name: Barouch, Dan H.
name: Ananworanich, Jintanat
name: Henrich, Timothy J.
name: Grossman, Cynthia
name: Tolstrup, Martin
name: Margolis, David
name: Valente, Susana
name: Deeks, Steven G.
name: Singh, Jerome
name: Sharp, Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Antiretroviral therapy is not curative. Given the challenges in providing life-long therapy to a global population of over 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.
Community Work Practice Skills: lndividual Reflection
Creators: name: Ozies, Jaala
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 500306
subject: Ethical theory
classificationCode: 470207
subject: Cultural theory
classificationCode: 350707
subject: Leadership
classificationCode: 390403
subject: Educational administration, management and leadership
classificationCode: 440999
subject: Social work not elsewhere classified

description: This Assessment: Community Work Practice Skills Part 2 - lndividual Reflection was written in September 2023 during my Master of Social Work Studies at the University of Queensland.This reflection on community work practice emphasises skills gained from working in a group. It highlights the importance of collaboration, effective communication, and adaptability. The experience enhanced my ability to navigate diverse perspectives and foster inclusivity, all of which will inform and improve my future social work practice.
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
Creators: name: Dickey, Audrey S.
name: La Spada, Albert R.
name: Masliah, Eliezer
name: Gaasterland, Terry
name: Torres, Mark-Joseph Manalang
name: Flores, April L.
name: Ross, Christopher A.
name: Sopher, Bryce L.
name: Tsunemi, Taiji
name: Gilmore-Hall, Stephen K.
name: Arreola, Martin
name: Lazarowski, Eduardo R.
name: Miranda, Helen C.
name: Liu, Patrick P.
name: Arbez, Nicolas
name: Sampat, Kunal R.
name: Pinkerton, Anthony B.
name: Yeo, Gene W.
name: Lomas, Nicole
name: Akimov, Sergey S.
name: Buttgereit, Anne
name: Pineda, Victor V.
name: Magnuson, Gavin K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-polyglutamine repeat expansion in the huntingtin (htt) gene. We found that peroxisome proliferator-activated receptor delta (PPARδ) interacts with htt and that mutant htt represses PPARδ-mediated transactivation. Increased PPARδ transactivation ameliorated mitochondrial dysfunction and improved cell survival of HD neurons. Expression of dominant-negative PPARδ in CNS was sufficient to induce motor dysfunction, neurodegeneration, mitochondrial abnormalities, and transcriptional alterations that recapitulated HD-like phenotypes. Expression of dominant-negative PPARδ specifically in the striatum of medium spiny neurons in mice yielded HD-like motor phenotypes, accompanied by striatal neuron loss. In mouse models of HD, pharmacologic activation of PPAR δ, using the agonist KD3010, improved motor function, reduced neurodegeneration, and increased survival. PPAR δ activation also reduced htt-induced neurotoxicity in vitro and in medium spiny-like neurons generated from human HD stem cells, indicating that PPAR δ activation may be beneficial in individuals with HD and related disorders.
Supplementary documentation for SAEON's field instrument data collected at the SIBHAYI EAST station
Creators: name: South African Environmental Observation Network (SAEON) Grasslands-Forests-Wetlands Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Sibhayi
Hydrological
Pressure transducer
Ground Water level
Lake level

description: This package contains supporting information for the hydrological data collected at SIBHAYI's EAST station, as part of the South African Environmental Observation Network's monitoring projects.
The fast filament eruption leading to the X-flare on March 29, 2014
Creators: name: Kleint, Lucia
name: Battaglia, Marina
name: Reardon, Kevin
name: Dalda, Alberto Sainz
name: Young, Peter R.
name: Krucker, Säm
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the sequence of events leading to the solar X1 flare SOL2014-03-29T17:48. Because of the unprecedented joint observations of an X-flare with the ground-based Dunn Solar Telescope and the spacecraft IRIS, Hinode, RHESSI, STEREO, and SDO, we can sample many solar layers from the photosphere to the corona. A filament eruption was observed above a region of previous flux emergence, which possibly led to a change in magnetic field configuration, causing the X-flare. This was concluded from the timing and location of the hard X-ray emission, which started to increase slightly less than a minute after the filament accelerated. The filament showed Doppler velocities of $\sim$2-5 km s$^{-1}$ at chromospheric temperatures for at least one hour before the flare occurred, mostly blueshifts, but also redshifts near its footpoints. 15 minutes before the flare, its chromospheric Doppler shifts increased to $\sim$6-10 km s$^{-1}$ and plasma heating could be observed, before it lifted off with at least 600 km s$^{-1}$, as seen in IRIS data. Compared to previous studies, this acceleration ($\sim$3-5 km s$^{-2}$) is very fast, while the velocities are in the common range for coronal mass ejections. An interesting feature was a low-lying twisted second filament near the erupting filament, which did not seem to participate in the eruption. After the flare ribbons started on each of the second filament's sides, it seems to have untangled and vanished during the flare. These observations are some of the highest resolution data of an X-class flare to date and reveal some small-scale features yet to be explained.
description: Accepted for publication by ApJ
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
Creators: name: Foo, Shane
name: Nyström, Hanna
name: Kostaras, Eleftherios
name: Frentzas, Sophia
name: Salman, Ayat
name: Loyer, Evelyne
name: Daley, Frances
name: Simoneau, Eve
name: Brown, Gina
name: Cunningham, David
name: Gazinska, Patrycja
name: Eltahir, Zak
name: Khashper, Alla
name: Berg, Tracy J.
name: Wotherspoon, Andrew
name: Peckitt, Clare
name: Nathan, Mark R
name: Van Rheenen, Jacco
name: Shi, Yu
name: Van Den Eynden, Gert
name: Van Laere, Steven
name: Metrakos, Peter
name: Lazaris, Anthoula
name: Dirix, Luc
name: Sund, Malin
name: Bridgeman, Victoria L.
name: Reynolds, Andrew R.
name: Ritsma, Laila
name: Tan, Xianming
name: Gao, Zu-Hua
name: Vermeulen, Peter B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of inducing angiogenesis, some cancers vascularize by the non-angiogenic mechanism of vessel co-option. Here we show that vessel co-option is associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal cancer liver metastases. Moreover, we find that vessel co-option prevails in human breast cancer liver metastases, a setting where results with anti-angiogenic therapy have been disappointing. In our preclinical mechanistic studies, we show that cancer cell motility mediated by the Arp2/3 complex is required for vessel co-option in liver metastases in vivo and that combined inhibition of angiogenesis and vessel co-option is more effective than inhibiting angiogenesis alone in this setting. Vessel co-option is therefore a clinically relevant mechanism of resistance to anti-angiogenic therapy and combined inhibition of angiogenesis and vessel co-option may be a warranted therapeutic strategy.
title: Some basic characteristics of wood
Creators: name: Hutcheon, N. B.
name: Henkins, J. H.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1967
Subjects: subject: wood (materials)
subject: bois (matériau)
subject: trees (plants)
subject: arbre (plante)
subject: strength of materials
subject: résistance des matériaux

description: The way in which a tree grows and the nature of the resulting wood substance give rise to directional properties for strength and shrinkage which have important implications in the processing and use of wood.
Line Intercept in Hawequas, Kromriver Hut, site 3319CA/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Hawequas
Line Intercept
Kromriver

description: This is a scanned copy of a line intercept in Hawequas, Kromriver Hut, site 3319CA/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Complete genome sequence and annotation of Pantoea anthophila CL1
Creators: name: Liu, Qingmei
Publisher: name: figshare
Year: 2022
Subjects: subject: 79999 Agricultural and Veterinary Sciences not elsewhere classified
subject: FOS: Other agricultural sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 60704 Plant Pathology
subject: Plant Biology
subject: 60309 Phylogeny and Comparative Analysis
subject: 60409 Molecular Evolution

description: Complete genome sequence and annotation of Pantoea anthophila CL1
Plain language summary for the manuscript: Etanercept Withdrawal and Re-Treatment in Non-Radiographic Axial Spondyloarthritis: Results of RE-EMBARK, an Open-Label, Phase IV Trial
Creators: name: Bosch, Filip Van den
name: Wei, James Cheng-Chung
name: Nash, Peter
name: Blanco, Francisco J.
name: Graham, Daniela
name: Zang, Chuanbo
name: Arthur, Edmund
name: Borlenghi, Cecilia
name: Tsekouras, Vassilis
name: Vlahos, Bonnie
name: Deodhar, Atul
Publisher: name: Pfizer
Year: 2023
Subjects: Rheumatology and arthritis

description: This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the orignial manuscript was not involved in the preparation of this PLS and has neither reviewed not approved its content.
Blechnum anthracinum R. C. Moran, Novon
Creators: name: Smith, Alan R.
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Blechnaceae
Blechnum
Blechnum anthracinum

description: Blechnum anthracinum R.C.Moran, Novon 2: 132. 1992.
 Range:— Endemic to Bolivia, where known only from a small area near Chuspipata (LP).
 Ecology:— Local and uncommon; epiphytic in humid forests; 3150–3250 m.
description: Published as part of Smith, Alan R. & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XXXIII. Blechnaceae, pp. 99-117 in Phytotaxa 334 (2) on page 103, DOI: 10.11646/phytotaxa.334.2.1, http://zenodo.org/record/13721528