Additional file 1 of Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones
Creators: name: Zeng, Hui
name: Yang, Zhuoyu
name: Li, Jiang
name: Wen, Yan
name: Wu, Zheng
name: Zheng, Yadi
name: Yu, Yiwen
name: Xu, Yongjie
name: Gao, Shugeng
name: Tan, Fengwei
name: Li, Ni
name: Xue, Qi
name: He, Jie
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1 : Table S1. Search strategy (Supplementary Table S1) [29]. Table S2. Characteristics of included studies (Supplementary Table S2) [29]. a. 0 = Cohort, 1 = Case-control; b. 0 = Premenopausal, 1 = Postmenopausal, 2 = Premenopausal/Postmenopausal; c. 0 = Never, 1 = Ever/never; d. 0 = Adenocarcinoma, 1 = NSCLC, 2 = SCLC/NSCLC; e. 0 = Population-based controls, 1 = Hospital-based controls, 2 = population-based + hospital-based controls. Table S3. Quality Assessment According to the Modified Newcastle-Ottawa Scale (NOS) a (Supplementary Table S3) [29]. a. 0 = no star allocated;1 = one star allocated; 2 = two stars allocated; b. Case-control studies are scored on the exposure of interest, whereas cohort and cross-sectional studies are scored on the outcome of interest. Figure S1. Forest plots for high sex steroid hormone exposure on the risk of lung cancer with studies assessed both endogenous and exogenous sex steroid hormones (Supplementary Figure S1) [29]. a. OR: Odds ratio; b. CI: Confidence interval; c. OC: Oral contraception; d. HRT: Hormone replacement therapy. Figure S2. Forest plots for high sex steroid hormone exposure on the risk of lung cancer with (a) 1987–2007 and (b) 2008–2019 (Supplementary Figure S2) [29]. a. OR: Odds ratio; b. CI: Confidence interval; c. OC: Oral contraception; d. HRT: Hormone replacement therapy. Figure S3. Forest plots for high sex steroid hormone exposure on the risk of lung cancer with (a) Retrospective studies and (b) Prospective studies (Supplementary Figure S3) [29]. a. OR: Odds ratio; b. CI: Confidence interval; c. OC: Oral contraception; d. HRT: Hormone replacement therapy. Figure S4. Forest plots for higher levels of sex steroid hormone exposure on the risk of female lung cancer with (a) Never-smokers and (b) Ever-smokers in different ethnicities (Supplementary Figure S4) [29]. a. OR: Odds ratio; b. CI: Confidence interval. Figure S5. Funnel Plot (Supplementary Figure S5) [29]. Figure S6. Egger’s funnel plot for assessing potential publication bias (Supplementary Figure S6) [29]. Figure S7. Sensitivity Analysis by the Leaving-One-Out Method (Supplementary Figure S7) [29]. Figure S8. The levels of endogenous sex steroid hormone exposure during development among women (Supplementary Figure S8) [29]. Women, with younger age at menarche, older age at menopause, longer reproductive window, longer length of each cycle and reproductive factors, will have higher exposure of cells to endogenous sex steroid hormones over a lifetime.