cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Creators: name: Carli, Annalisa Leandra Elena
name: Afshar-Sterle, Shoukat
name: Rai, A
name: Fang, H
name: O'Keefe, Ryan
name: Tse, Janson
name: Ferguson, FM
name: Gray, NS
name: Ernst, Matthias
name: Greening, David
name: Buchert, Michael
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Doublecortin-like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric cancer (GC). DCLK1 overexpression in a majority of solid cancers correlates with lymph node metastases, advanced disease and overall poor-prognosis. In cancer cells, DCLK1 expression has been shown to promote epithelial-to-mesenchymal transition (EMT), driving disruption of cell-cell adhesion, cell migration and invasion. Here, we report that DCLK1 influences small extracellular vesicle (sEV/exosome) biogenesis in a kinase-dependent manner. sEVs isolated from DCLK1 overexpressing human GC cell line MKN1 (MKN1OE-sEVs), promote the migration of parental (non-transfected) MKN1 cells (MKN1PAR). Quantitative proteome analysis of MKN1OE-sEVs revealed enrichment in migratory and adhesion regulators (STRAP, CORO1B, BCAM, COL3A, CCN1) in comparison to MKN1PAR-sEVs. Moreover, using DCLK1-IN-1, a specific small molecule inhibitor of DCLK1, we reversed the increase in sEV size and concentration in contrast to other EV subtypes, as well as kinase-dependent cargo selection of proteins involved in EV biogenesis (KTN1, CHMP1A, MYO1G) and migration and adhesion processes (STRAP, CCN1). Our findings highlight a specific role of DCLK1-kinase dependent cargo selection for sEVs and shed new light on its role as a regulator of signaling in gastric tumorigenesis.
Configuring maternal, preborn and infant embodiment
Creators: name: Lupton, Deborah
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology

description: An examination of the sociocultural meanings of pregnant embodiment and the ways in which unborn bodies and newborn bodies are conceptualised in relation to the maternal body/self
'I'm always on the lookout for what could be going wrong': mothers' concepts and experiences of health and illness in their young children
Creators: name: Lupton, Deborah
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology

description: Reports the findings of a study using qualitative interviews with mothers of young children about how they conceptualise their children's health and attempt to promote good health and optimal development in their children
MPEC 2025-H27 : 2025 HD
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 HD

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Verfassungsblatt: 2023/12
Creators: name: :None
Publisher: name: Verfassungsblog gGmbH
Year: 2024
Subjects: subject: Verfassungsrecht
subject: constitutional law
subject: Verfassungspolitik
subject: constitutional policy
subject: 340

description: Verfassungsblatt, vol. 1 (2023), no. 12, p. 1863
title: Konturen rechtswissenschaftlicher Forschung in Deutschland: eine Kartierung für das Jahr 2023
Creators: name: Rechtsforschung, Fachinformationsdienst
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 340

description: Forschungskartierung: Zur Entwicklung rechtswissenschaftlicher Themenfelder in Deutschland
Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition
Creators: name: Cohen, Charles
name: De Blasio, MJ
name: Lee, MKS
name: Farrugia, Gabriella
name: Prakoso, D
name: Krstevski, Crisdion
name: Deo, M
name: Donner, DG
name: Kiriazis, H
name: Flynn, MC
name: Gaynor, Taylah
name: Murphy, Andrew
name: Drummond, Grant
name: Pinto, Ruvantha
name: Ritchie, Rebecca
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3208
subject: Medical physiology

description: Background: Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes accompanying diabetes yet to be examined in detail. This study aims to characterise the changes in the cardiac cellular landscape in murine diabetes to identify potential cellular protagonists in the diabetic heart. Methods: Diabetes was induced in male FVB/N mice by low-dose streptozotocin and a high-fat diet for 26-weeks. Cardiac function was measured by echocardiography at endpoint. Flow cytometry was performed on cardiac ventricles as well as blood, spleen, and bone-marrow at endpoint from non-diabetic and diabetic mice. To validate flow cytometry results, immunofluorescence staining was conducted on left-ventricles of age-matched mice. Results: Mice with diabetes exhibited hyperglycaemia and impaired glucose tolerance at endpoint. Echocardiography revealed reduced E:A and e’:a’ ratios in diabetic mice indicating diastolic dysfunction. Systolic function was not different between the experimental groups. Detailed examination of cardiac cellularity found resident mesenchymal cells (RMCs) were elevated as a result of diabetes, due to a marked increase in cardiac fibroblasts, while smooth muscle cells were reduced in proportion. Moreover, we found increased levels of Ly6Chi monocytes in both the heart and in the blood. Consistent with this, the proportion of bone-marrow haematopoietic stem cells were increased in diabetic mice. Conclusions: Murine diabetes results in distinct changes in cardiac cellularity. These changes—in particular increased levels of fibroblasts—offer a framework for understanding how cardiac cellularity changes in diabetes. The results also point to new cellular mechanisms in this context, which may further aid in development of pharmacotherapies to allay the progression of cardiomyopathy associated with diabetes.
ВОЗВРАЩЕНИЕ Л.Д. ТРОЦКОГО В РОССИЮ В ЗЕРКАЛЕ СОЦИАЛИСТИЧЕСКОЙ ПЕЧАТИ 1917 ГОДА
Creators: name: РАЧКОВСКИЙ ВАЛЕРИЙ АЛЕКСАНДРОВИЧ
name: ШУМЯКОВ РАУФ АРТУРОВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: ТРОЦКИЙ
ГАЛИФАКС
"ПРАВДА"
"РАБОЧАЯ ГАЗЕТА"
ПОЛИТИЧЕСКИЕ ЭМИГРАНТЫ
1917
ЛЕНИН
БОЛЬШЕВИКИ
МЕНЬШЕВИКИ
TROTSKY
HALIFAX
"PRAVDA"
"RABOCHAYA GAZETA"
RUSSIAN POLITICAL
BOLSHEVIKS
EMIGRANTS
LENIN
MENSHEVIKS

description: Статья посвящена реакции социалистической периодической печати Петрограда на задержание Л.Д. Троцкого в канадском порту Галифакс на пути в Россию и на прибытие его в Петроград 4 мая 1917 г. Рассматриваются публикации таких газет как «Правда», «Рабочая газета», «Известия Петроградского Совета рабочих и солдатских депутатов», «Единство», «День», «Воля народа», «Дело народа», «Новая жизнь». Особое внимание уделено публикационной активности по данным вопросам «Правды» и «Рабочей газеты». В результате авторы приходят к выводу, что обилие помещенных материалов по теме задержания эмигрантов в Галифаксе, формирование положительного образа Троцкого имеют ряд причин. Помимо партийной солидарности, большевики руководствовались перспективой сотрудничества с Троцким по прибытии того в Петроград, возможностью реабилитировать посредством этой новости группу В.И. Ленина, проехавшую через Германию, агитировать за свою программу (против империализма вне и внутри страны). Интерес к Троцкому со стороны меньшевиков следует объяснять, вероятно, влиянием интернационалистски настроенной Петроградской организации РСДРП, обостренным вниманием к вопросу возвращения эмигрантов из-за неясного положения Л. Мартова, П.Б. Аксельрода и других меньшевиков в Швейцарии. Отмечается, что на приезд Л.Д. Троцкого обратили внимание лишь «Правда», «Новая жизнь» и, подспудно, «Дело народа». Авторы приходят к заключению, что игнорирование факта приезда «Рабочей газетой» отразило процесс склонения редакции в сторону коалиционного правительства, поскольку прибытие Э. Вандервельде не было пропущено, хотя он и Троцкий прибыли в одном вагоне.
Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition
Creators: name: Cohen, Charles
name: De Blasio, MJ
name: Lee, MKS
name: Farrugia, GE
name: Prakoso, D
name: Krstevski, Crisdion
name: Deo, M
name: Donner, DG
name: Kiriazis, H
name: Flynn, MC
name: Gaynor, Taylah
name: Murphy, Andrew
name: Drummond, Grant
name: Pinto, Ruvantha
name: Ritchie, Rebecca
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes accompanying diabetes yet to be examined in detail. This study aims to characterise the changes in the cardiac cellular landscape in murine diabetes to identify potential cellular protagonists in the diabetic heart. Methods: Diabetes was induced in male FVB/N mice by low-dose streptozotocin and a high-fat diet for 26-weeks. Cardiac function was measured by echocardiography at endpoint. Flow cytometry was performed on cardiac ventricles as well as blood, spleen, and bone-marrow at endpoint from non-diabetic and diabetic mice. To validate flow cytometry results, immunofluorescence staining was conducted on left-ventricles of age-matched mice. Results: Mice with diabetes exhibited hyperglycaemia and impaired glucose tolerance at endpoint. Echocardiography revealed reduced E:A and e’:a’ ratios in diabetic mice indicating diastolic dysfunction. Systolic function was not different between the experimental groups. Detailed examination of cardiac cellularity found resident mesenchymal cells (RMCs) were elevated as a result of diabetes, due to a marked increase in cardiac fibroblasts, while smooth muscle cells were reduced in proportion. Moreover, we found increased levels of Ly6Chi monocytes in both the heart and in the blood. Consistent with this, the proportion of bone-marrow haematopoietic stem cells were increased in diabetic mice. Conclusions: Murine diabetes results in distinct changes in cardiac cellularity. These changes—in particular increased levels of fibroblasts—offer a framework for understanding how cardiac cellularity changes in diabetes. The results also point to new cellular mechanisms in this context, which may further aid in development of pharmacotherapies to allay the progression of cardiomyopathy associated with diabetes.
title: #33 Advisory Opinions: High Politics vor Internationalen Gerichten
Creators: name: Lischewski, Isabel
name: Hinselmann, Jan-Henrik
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 341

description: Wie gelangen wesentliche politische Fragen überhaupt noch vor internationale Gerichten? Scheinbar zunehmend auf dem Wege von Advisory Opinions (Rechtsgutachten). Isabel Lischewski führt ein in die Voraussetzungen, unter denen der Internationale Gerichtshof (IGH) Rechtsgutachten erteilt. Jan-Henrik Hinselmann spricht dann mit Christoph Priess über die Konjunktur dieser Verfahrensart und ihre vielen spannenden Implikationen. Wir freuen uns über Lob, Anmerkungen und Kritik an ⁠podcast@voelkerrechtsblog.org⁠. Abonniert unseren Podcast ⁠via RSS⁠, über ⁠Spotify⁠ oder überall dort, wo es Podcasts gibt. Zeitstempel: 02:30 – Grundlagen: Die Eastern Carelia-Doktrin des IGH 07:15 – Aktuelle (Klima-)Advisory Opinions im Überblick 11:20 – Parallelität von Advisory Opinions: Fluch oder Segen? 18:04 – Advisory Opinions als “prozessuale Umgehungskonstruktion”? 23:35 – Israel-Palästina-Konflikt als „bilateraler Konflikt“? 27:28 – Zur Verbindlichkeit von Advisory Opinions 31:43 – Was folgt für künftige Gutachtenverfahren? 35:05 – Nachbesprechung Hintergrundinformationen: IGH: ⁠United Nations General Assembly Request for Advisory Opinion of the International Court of Justice: Obligations of States in Respect of Climate Change⁠, 29 March 2023 IACtHR: ⁠Request for Advisory Opinion of the Inter-American Court of Human Rights⁠, 9 January 2023 ITLOS: ⁠Request for Advisory Opinion of the International Tribunal for the Law of the Sea: Climate Change and International Law⁠, 12 December 2022 Benoit Mayer, ⁠International Advisory Proceedings on Climate Change⁠ Philip Burton, ⁠Searching for the Eastern Carelia Principle⁠ Moderation: ⁠Jan-Henrik Hinselmann⁠, LL.M. (NYU) & ⁠Dr. Isabel Lischewski⁠ Grundlagen: ⁠Dr. Isabel Lischewski⁠ Interview: Christoph Priess, LL.M. (Cambridge) & Jan-Henrik Hinselmann, LL.M. (NYU) Schnitt: Daniela Rau Credits: Gaston Browne, Prime Minister of Antigua and Barbuda, Public sitting held on Monday, 11 September 2023, at the International Tribunal for the Law of the Sea, Hamburg. (⁠Transcript⁠; ⁠Recordings⁠)
description: Völkerrechtsblog
Culture Vivarium, an cultural plant in the Southern Italy, based on a network of CULTLabs, connected by an HPW ecosystem, accelerating innovative manufacturing modeling and re-use of Cultural Heritage items
Creators: name: Laquidara, Giuseppe
name: Boém, Marika Mazzi
name: Colombani, Margaret
name: Elia, Annibale
name: Marano, Federica
name: Fascione, Valeria
name: Montanari, Roberto
name: Tesone, Gennaro
Publisher: name: figshare
Year: 2013
Subjects: subject: Education
subject: Computational Physics
subject: Performing Arts
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Economics
subject: Applied Computer Science

description: The project named “Culture Vivarium” aims to create an “industrial cultural district”, i.e. a vibrant aggregating hub of creative and cultural industries (CCIs) using and reusing the cultural heritage of the Campania region to start and successfully develop high impact cultural and creative business models. To achieve this aims, the project builds on two logical functional pillars: #1. a digital technological infrastructure, and #2. a physical network named “Culture Vivarium”, a broad ecosystem for incubating, accelerating, establishment and growth [Culture] of industrial prototyps and their products.
IMPLICATIONS OF LABOUR LEGISLATIONS IN INDIA: A REALISTIC ASSESSMENT
Creators: name: Sharanappa Saidapur
name: JAYAKUMAR  SINDHE
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: The country has the distinction of having some of the most comprehensive labour laws in the world, even while having one of the largest fractions of the working population is unprotected and under privileged. Labour legislations are protecting the interest of the labour and promoting the welfare of labour community in India. Modern states are welfare state; their motto is to achieve the happiness of workers. Labourers are pillars of production system. Without labourer we can't produce a single article in the economy. Providing basic facilities for workers is an obligatory duty of the state and enjoying the basic facilities of workers are fundamental rights of the labourer provided for in the Indian constitution. Labour legislation has grown up as one of the most important social institutions in India.
title: Genocide in Ukraine - Present Justiciability
Creators: name: Love, Edward
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 340

description: In our latest Saar Blueprint, Edward Love analyzes the question of whether the alleged forcible transfer of children from Ukraine constitutes genocide through the lens of international law. The thesis examines various legal frameworks and case law, including the Genocide Convention, and scrutinizes the actions and policies implemented in the region. The study analyzes the evidence available in relation to the legal definitions and criteria of genocide, providing a critical and thorough assessment of the situation's compliance with international legal standards. The author submitted this as his master's thesis for the LL.M. program at the Europa-Institut of Saarland University. It provides an insightful perspective on the complex legal nuances surrounding the events in Ukraine.
description: Saar Blueprints
“INCREASING PERFORMANCE THROUGH CREATION OF A CONDUCIVE WORK ENVIRONMENT”
Creators: name: Miss. Neeraj Kumari
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: The organizational culture can be one of the most important factors in deciding the success or failure of a large corporation, but it is also one of the hardest things to change about a company since by its very definition organizational culture is shared throughout the entire company. The aim of the study is to find how the sound organizational culture can affect the overall performance of the organization. Data is collected with the help of a structured questionnaire. Non probability sampling has been used with the sample size of 80. The study shows that there is a positive relationship between the organizational culture and the employee job performance. The paper concludes that the culture should be more participative. This will lead to transparency in the organization. Cross cultural issues should be given more emphasis.
Referential USD based on CPI-U (2012e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Referential USD provides the inflator/deflator multiplier for standardizing US dollars (within the philosophy of referential currencies).It is based on the average value of the United States consumer price index for all urban consumers - US CPI-U Average (United States Bureau of Labor Statistics, 2012). (Also retrievable from Wiki of Science.)
РАСПАД РУБЛЕВОЙ ЗОНЫ "НОВОГО ТИПА" (ПО МАТЕРИАЛАМ ПЕРИОДИЧЕСКОЙ ПЕЧАТИ)
Creators: name: ЗАХОВ АЛЕКСАНДР СЕРГЕЕВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: СНГ
РУБЛЬ
ЕДИНОЕ ЭКОНОМИЧЕСКОЕ ПРОСТРАНСТВО
ОБЩАЯ ВАЛЮТА
РОССИЯ
АРМЕНИЯ
КАЗАХСТАН
УЗБЕКИСТАН
БЕЛОРУССИЯ
ТАДЖИКИСТАН
CIS
RUBLE
COMMON ECONOMIC SPACE
COMMON CURRENCY
RUSSIA
ARMENIA
KAZAKHSTAN
UZBEKISTAN
BELARUS
TAJIKISTAN

description: В статье рассматриваются причины развала рублевой зоны «нового типа» попытки сохранения единой валюты в России, Белоруссии, Казахстане, Узбекистане, Таджикистане и Армении. Автор рассматривает как внутренние причины развала рублевой зоны «нового типа» (противоречия между странами СНГ и нежелание руководства Российской Федерации сохранять единую валюту), так и внешние причины (влияние Международного валютного фонда (МВФ) на политику государств-членов СНГ. Данная работа представляет интерес в свете нового витка интеграционного процесса на постсоветском пространстве, который происходит в настоящее время.
СОХРАНИМ ЛЕНИНГРАД? К ВОПРОСУ О ВОЗВРАЩЕНИИ ИСТОРИЧЕСКОГО НАЗВАНИЯ ГОРОДУ (ПО МАТЕРИАЛАМ ГАЗЕТЫ "ЛЕНИНГРАДСКАЯ ПРАВДА")
Creators: name: МАТЛИН АЛЕКСАНДР ДМИТРИЕВИЧ
name: ПУЧЕНКОВ АЛЕКСАНДР СЕРГЕЕВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: ЛЕНИНГРАД
"ЛЕНИНГРАДСКАЯ ПРАВДА"
ГАЗЕТА
АГИТАЦИЯ
ОПРОС 12 ИЮНЯ 1991 Г
ПРОПАГАНДА
САНКТ-ПЕТЕРБУРГ
LENINGRAD
LENINGRADSKAYA PRAVDA
NEWSPAPER
AGITATION
PROPAGANDA
ST. PETERSBURG

description: В статье рассматривается агитационная кампания за сохранение названия «Ленинград», предпринятая ленинградскими коммунистами перед общегородским опросом 12 июня 1991 г. о возвращении городу на Неве его исторического названия «Санкт-Петербург». По мнению авторов, такая агитация наиболее ярко и показательно была выражена в газетных материалах органа Ленинградского горкома и обкома партии газеты «Ленинградская Правда», выходивших с мая по июнь 1991 г. Газета была одним из наиболее влиятельных ленинградских печатных изданий периода перестройки и безусловно поддерживала коммунистический курс. На наш взгляд, её анализ важен для понимания агитационной кампании сторонников «Ленинграда». В статье исследованы характерные статьи, опубликованные в газете накануне опроса и проанализированы основные аргументы, использованные коммунистами. На основе рассмотренных материалов определяются причины провала коммунистов в этой информационной кампании. Авторы приходят к заключению, что основной ошибкой коммунистов стала агрессивная форма ведения этой информационной кампании, направленная в первую очередь на собственный электорат. Статья основана на широком круге источников.
ВАСИЛЬКОВИЧИ: ТРАГЕДИЯ И ПОДВИГ
Creators: name: БЕРЕДНИКОВА ВИКТОРИЯ ЕВГЕНЬЕВНА
name: ИЛЬИН ЕВГЕНИЙ ВАСИЛЬЕВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: ВЕЛИКАЯ ОТЕЧЕСТВЕННАЯ ВОЙНА
ЛЕНИНГРАДСКАЯ ОБЛАСТЬ
МЫЗА ВАСИЛЬКОВИЧИ
ПОСЕЛОК ТОРКОВИЧИ
ГЕНОЦИД
ПАРТИЗАНЫ
ПОДПОЛЬНОЕ ДВИЖЕНИЕ
КОЛЛАБОРАЦИОНИЗМ
ПАМЯТЬ
GREAT PATRIOTIC WAR
LENINGRAD REGION
GRANGE VASIL'KOVICHI
VILLAGE TORKOVICHI
GENOCIDE
PARTISANS
UNDERGROUND MOVEMENT
COLLABORATION
MEMORY

description: В статье рассматриваются вопросы проведения в жизнь «нового порядка» на оккупированной территории СССР в годы Великой Отечественной войны. Объектом исследования является Оредежский район Ленинградской области, оказавшийся в оккупации в августе 1941 года. Особое внимание уделяется репрессивной политике по отношению к гражданскому населению; применению практики массовых расстрелов, геноциду, а также деятельность партизан и подпольщиков, направленной против оккупационных войск, раскрытая на конкретных примерах. Освещаются вопросы деятельности молодежной подпольной группы в поселке Торковичи, деятельности немецких карательных органов, в частности, карательного отряда СД, укомплектованного из местных коллаборационистов. Подняты вопросы сохранения памяти о защитниках Отечества и увековечивания памяти героев. Актуальность исследования обусловлена важностью определения места подвига в исторической памяти России партизан и гражданского населения, сражавшегося наравне с регулярной армией против оккупантов. В статье описан не только теоретический, но и многолетний практический опыт авторов по проведению работ в сфере поиска и увековечиванию памяти защитников Отечества и гражданского населения, погибших или пропавших без вести в годы Великой Отечественной войны.
Fear of judgement and women's physical (in)activity experiences
Creators: name: Seal, Emma
name: Nicholson, Matthew
name: McNeil, Nicola
name: Stukas, Arthur
name: O'Halloran, Paul
name: Randle, Erica
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4206
subject: Public health
classificationCode: 4207
subject: Sports science and exercise
classificationCode: 44
subject: Human society
classificationCode: 4410
subject: Sociology
subject: FOS: Sociology

description: No description supplied
Nutritional balance of wheat cravers
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Medicine

description: Perezgonzalez assessed the nutritional balance of wheat cravers in 2012, as part of a research on the nutritional composition of snacks in New Zealand. Wheat cravers had, on average, a nutritional unbalance of BNI 55.71na, being particularly biased towards excess of sodium. They were also adequate in carbohydrate, sugar and saturated fat, high in fat, and low in protein and fiber. (Also retrievable from Wiki of Science.)
Nutritional balance of rice cravers (descriptive statistics)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Medicine

description: Perezgonzalez assessed the nutritional balance of rice cravers in 2012, as part of a research on the nutritional composition of snacks in New Zealand. The distribution of nutritional balance was rather flat, due to the small number of products under research. The median was located at BNI 60.60 and the middle 68% of products ranged between BNI 42 (P16) and BNI 74 (P84). There was a slight positive skewness (mean=60.77, zSkew=1.59), although, given the size of the sample and the shape of the distribution, this may be of little practical importance. The distribution of nutritional balance varied slightly according to the particular recommended dietary intakes (RDIs) of reference, although all followed a pattern similar to the one just described. Even so, this group of products appeared slightly less unbalanced under US' and WHO's RDIs than under UK's and Australia's RDIs. (Also retrievable from Wiki of Science.)
ВЗГЛЯДЫ РОССИЙСКИХ КОНСЕРВАТИВНЫХ ПУБЛИЦИСТОВ НА ПЕРСПЕКТИВЫ РУССКО-ЯПОНСКОЙ ВОЙНЫ В ЯНВАРЕ 1904 Г. (НА ПРИМЕРЕ "МОСКОВСКИХ ВЕДОМОСТЕЙ")
Creators: name: ЕРМОЛАЕВ ИГОРЬ ВЛАДИМИРОВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: РУССКО-ЯПОНСКАЯ ВОЙНА
РОССИЙСКАЯ ПУБЛИЦИСТИКА
"МОСКОВСКИЕ ВЕДОМОСТИ"
ОБРАЗ ВРАГА
ОБРАЗ ЯПОНИИ И ЯПОНЦЕВ
RUSSO-JAPANESE WAR
RUSSIAN JOURNALISM
"MOSKOVSKIYE VEDOMOSTI"
IMAGE OF THE ENEMY
THE IMAGE OF JAPAN AND THE JAPANESE

description: В статье анализируются представления консервативных публицистов «Московских ведомостей» в январе 1904 г. на перспективы русскояпонской войны. Предпринята попытка реконструкции и анализа хода мыслей и аргументации российских публицистов-консерваторов. Поднимается вопрос о причинах формирования у консерваторов искаженного представления о предстоящей военной кампании. Уделяется внимание проблеме формирования образа Японии и японцев в России в довоенный период. Дается характеристика авторам статей «Московских ведомостей» этого периода. Рассматриваются различные проблемные вопросы, такие как: образ японцев к началу войны, зависимость Японии от Великобритании, возможные сценарии развития боевых действий. Автор обращает внимание на изменении риторики публицистов после официального объявления войны. Новизна исследования видится в том, что ранее взгляды российской консервативной прессы на перспективы русско-японской войны исследователями отдельно не рассматривались. Актуальность исследования обусловлена недостаточной изученностью социальнопсихологических аспектов русско-японской войны в российской историографии. Автор приходит к выводу, что пренебрежительное отношение к набиравшей силу азиатской державе привело к недостаточной осведомленности публицистов о ее возможностях, что негативным образом повлияло на их прогнозы.
ЗАВЕРШАЮЩИЙ ЭТАП ГРАЖДАНСКОЙ ВОЙНЫ НА ЮГЕ РОССИИ. ТЕРСКИЕ КАЗАКИ В АРМИИ ВОЗРОЖДЕНИЯ РОССИИ ФОСТИКОВА
Creators: name: ПЫЛЬЦЫН ЮРИЙ СЕРГЕЕВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: АРМИЯ ВОЗРОЖДЕНИЯ РОССИИ
БЕЛОЕ ДВИЖЕНИЕ
ГЕНЕРАЛ В. И. СТАРИЦКИЙ
ГЕНЕРАЛ М. А. ФОСТИКОВ
ГРАЖДАНСКАЯ ВОЙНА
КУБАНСКОЕ КАЗАЧЕСТВО
ТЕРСКОЕ КАЗАЧЕСТВО
ARMY RENAISSANCE OF RUSSIA
CIVIL WAR
GENERAL M.A. FOSTIKOV
GENERAL V.I. STARITSKY
KUBAN COSSACKS
TEREK COSSACKS
WHITE MOVEMENT

description: После отступления Вооружённых Сил Юга России с Северного Кавказа в Крым, на территориях, занятых Красной армией остались политические противники большевистского режима, которые вовсе не собирались складывать оружия. Традиционной опорой Белого движения на Юге России считались казачьи войска и на территории этих войск повстанческое движение в 1920 г. являлось значительной силой. В статье рассматривается служба терских казаков в Армии возрождения России (АВР), которая действовала на Кубани под началом генерала М. А. Фостикова в 1920 г. Сделана попытка реконструировать боевой путь частей, где служили терские казаки. Особое место уделяется конфликту двух военачальников Армии кубанского казака М. А. Фостикова и его начальника штаба терского казака полковника В. И. Старицкого. Внимание уделяется так же эвакуации интернированных бойцов Армии возрождения России из Грузии в Крым. Несмотря на то, что восстание на Кубани развивалось успешно, а Армия Возрождения России нанесла красным несколько чувствительных поражений, силы были слишком неравны, что и закончилось отступлением фостиковцев в Грузию. Терские казаки в армии Фостикова принимали в боях активное участие, из них были даже составлены некоторые подразделения, но широкое привлечение терцев к повстанческой работе было невозможно, т. к. АВР заняла только одну станицу Терского войска. Конфликт между М. А. Фостиковым и В. И. Старицким являлся одним из проявлений кризиса повстанческого движения на Кубани, но случился он уже в период отступления АВР. Причиной поражения армии или свидетельством конфликтов между терским и кубанским казачьими войсками конфликт не являлся.
title: Vanilla :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Vanilla

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
ДЕЯТЕЛЬНОСТЬ ВОЙСК НКВД СССР НА СЕВЕРНОМ КАВКАЗЕ В 1941-1943 ГГ. (К 75-ЛЕТИЮ ВЕЛИКОЙ ПОБЕДЫ СОВЕТСКОГО НАРОДА)
Creators: name: СИДОРЕНКО ВАСИЛИЙ ПАВЛОВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: АРМЕЙСКИЕ ЧАСТИ
БАНДГРУППЫ
ГОРНЫЕ ПЕРЕВАЛЫ
ДИВЕРСАНТЫ
ДИВИЗИИ НКВД
ЗАКАВКАЗСКИЙ ФРОНТ
ОСОБЫЕ ОБОРОНИТЕЛЬНЫЕ РАЙОНЫ
СЕВЕРНЫЙ КАВКАЗ
СЕВЕРНАЯ ГРУППА ВОЙСК
ARMY UNITS
BAND GROUPS
MOUNTAIN PASSES
SABOTEURS
NKVD DIVISIONS
TRANSCAUCASIAN FRONT
SPECIAL DEFENSE AREAS
NORTH CAUCASUS
NORTHERN GROUP OF FORCES

description: В статье раскрываются основные направления служебно-боевой деятельности войск Наркомата внутренних дел (НКВД) СССР в особых оборонительных районах Северного Кавказа, которые в период битвы за Кавказ явились основной преградой на пути наступавшегопротивника. Деятельность частей Красной армии, пограничных войск, органов госбезопасности и милиции в статье рассматривается в тех аспектах, когда они выполняли служебные задачи во взаимодействии с внутренними войсками НКВД СССР.
ОПЕРАЦИЯ "МАРС" В НОВЕЙШЕЙ ИСТОРИОГРАФИИ
Creators: name: СОБОЛЕВ ГЕННАДИЙ ЛЕОНТЬЕВИЧ
name: ЗАРЕЧНЫЙ ЕГОР ЕВГЕНЬЕВИЧ
Publisher: name: Russian Colonial Studies
Year: 2019
Subjects: ВЕЛИКАЯ ОТЕЧЕСТВЕННАЯ ВОЙНА 1941-1945 ГГ
РЖЕВ
ОПЕРАЦИЯ "МАРС"
1942 Г
СТАЛИНГРАД
Г.К. ЖУКОВ
GREAT PATRIOTIC WAR 1941-1945
G.K. ZHUKOV
STALINGRAD
RZHEV
OPERATION "MARS"

description: Операция «Марс» проводилась Красной Армией в ноябре-декабре 1942 года на Ржевско-Вяземском выступе. Калининскому и Западному фронтам предстояло разгромить 9-ю армию Моделя, которая составляла основу группы армий «Центр». Параллельно под Сталинградом осуществлялась операция «Уран», нацеленная на уничтожение 6-й армии Паулюса. Оба советских наступления имели схожие задачи и осуществлялись в рамках единого замысла Ставки ВГК примерно равным числом сил. Но если «Уран» привел к победе, то «Марс» привел к поражению и на многие годы практически исчез из официальной историографии. В данной статье авторы проследили основные вехи развития научных представлений об операции «Марс» и выявили проблемные вопросы этого исторического сюжета.
CHILDBIRTH PRACTICES: AN EMPIRICAL STUDY AMONG INDIAN MUSLIM COMMUNITY
Creators: name: A. K. Ravisankar
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: In India, even though the progress is notable, the annual rate of MMR decline is less than half of what is needed to achieve the MDG5 target. A little bit of care and awareness is sufficient to prevent this tragedy. Place of delivery and person who conducted child delivery are an important indicator in monitoring progress towards MDG5. With this perspective, present study with an objective to find out delivery practices among Indian Muslims. Data were drawn from 30944 Muslim women who reported information about their last delivery at DLHS-3. Though a considerable proportion of Muslim women received the ANC care (any ANC- 60percent, 71.7percent made 3 ANC visits and 61percent consumed 90IFA tablets), around sixty percent of them preferred home deliveries and two-third of these deliveries were attended by DAI and 24percent of deliveries were managed by friends/relatives. Proportions of home deliveries were higher among rural women (67.9percent), illiterates (75.8percent), lowest WI quintile (86.2percent), and higher birth order babies (80.7percent). Around 37percent reported, visiting health facilities is not necessary and only 12percent reported health facilities are far way. Logistic regression result found hospital deliveries increase sharply with socio-economic status of the women especially higher educated mother (4.7 times) and richest women (5.1times). In the light of above results, greater availability of MCH services will not alone solve problem of low institutional delivery rates. Therefore, the implementing agencies should focus on the religious constraints which prevent the institutional deliveries and that need to be addressed urgently.
Nutritional balance of wheat cravers (descriptive statistics)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Medicine

description: Perezgonzalez assessed the nutritional balance of wheat cravers in 2012, as part of a research on the nutritional composition of snacks in New Zealand. The distribution of nutritional balance is shown in illustration 1. The median was located at BNI 55.65 and the middle 68% of products ranged between BNI 45 (P16) and BNI 69 (P84). There was a sensible positive skewness (mean=58.39, zSkew=3.68), probably exacerbated by the most extremely unbalanced product within the small sample. The distribution of nutritional balance varied slightly according to the particular recommended dietary intakes (RDIs) of reference, although all distributions followed a pattern similar to the one just described. Even so, this group of products appeared less unbalanced under WHO's, UK's, Australia's and, especially, US' RDIs. (Also retrievable from Wiki of Science.)
Nutritional balance of rice cravers
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Medicine

description: Perezgonzalez assessed the nutritional balance of rice cravers in 2012, as part of a research on the nutritional composition of snacks in New Zealand. Rice cravers had, on average, a nutritional unbalance of BNI 57.89na, being particularly biased towards deficiency in fiber. They were also adequate in sugar and saturated fat, high in carbohydrate and sodium, and low in protein and fat. (Also retrievable from Wiki of Science.)
Expressing 'Self' in a virtual world: Digital engagement for people with moderate to severe dementia
Creators: name: Salomon, Amanda
Publisher: name: Swinburne
Year: 2024

description: Mandy Salomon's thesis, entitled Expressing Self in a virtual world: Digital engagement for people with moderate to severe dementia, explores the lives of people with dementia to learn how interactive digital technologies might assist them. A group of aged care residents helped to design and evaluate a virtual world that was meaningful to them. When using the prototype, they experienced high levels of engagement. An outcome of the research is a design methodology that opens up new ways to improve the wellbeing of this significant user group.
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
Creators: name: Samuel, Monisha
name: Fonseka, Pamali
name: Sanwlani, Rahul
name: Gangoda, Lahiru
name: Chee, SH
name: Keerthikumar, Shivakumar
name: Spurling, A
name: Chitti, Sai Vara Prasad
name: Zanker, D
name: Ang, CS
name: Atukorala, Atukoralage
name: Kang, Taeyoung
name: Shahi, Sanjay
name: Marzan, Akbar Lulu
name: Nedeva, C
name: Vennin, C
name: Lucas, MC
name: Sim, Lesley
name: Herrmann, D
name: Pathan, Mohashin
name: Chisanga, David
name: Warren, SC
name: Zhao, Kening
name: Abraham, Nidhi
name: Anand, S
name: Boukouris, S
name: Adda, Christopher
name: Jiang, Lanzhou
name: Shekhar, Tanmay
name: Baschuk, N
name: Hawkins, Christine
name: Johnston, Amelia
name: Orian, Jacqueline
name: Hoogenraad, Nick
name: Poon, Ivan
name: Hill, Andrew
name: Jois, Markandeya
name: Timpson, P
name: Parker, Belinda
name: Mathivanan, Suresh
Publisher: name: La Trobe
Year: 2021
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and in-turn exert phenotypic changes is highly debatable. Here, we isolate EVs from both raw and commercial bovine milk and characterize them by electron microscopy, nanoparticle tracking analysis, western blotting, quantitative proteomics and small RNA sequencing analysis. Orally administered bovine milk-derived EVs survive the harsh degrading conditions of the gut, in mice, and is subsequently detected in multiple organs. Milk-derived EVs orally administered to mice implanted with colorectal and breast cancer cells reduce the primary tumor burden. Intriguingly, despite the reduction in primary tumor growth, milk-derived EVs accelerate metastasis in breast and pancreatic cancer mouse models. Proteomic and biochemical analysis reveal the induction of senescence and epithelial-to-mesenchymal transition in cancer cells upon treatment with milk-derived EVs. Timing of EV administration is critical as oral administration after resection of the primary tumor reverses the pro-metastatic effects of milk-derived EVs in breast cancer models. Taken together, our study provides context-based and opposing roles of milk-derived EVs as metastasis inducers and suppressors.
Fear of judgement and women's physical (in)activity experiences
Creators: name: Seal, Emma-Louise
name: Nicholson, Matthew
name: McNeil, Nicola
name: Stukas, Arthur
name: O'Halloran, Paul
name: Randle, Erica
Publisher: name: La Trobe
Year: 2022

description: There is a significant body of research that examines the antecedents and consequences of population-level disparities in physical activity engagement. However, there are still vast gendered inequalities with women missing out on the associated health benefits of physical activity compared to men. The purpose of this study is to foster a deep understanding of the ‘fear of judgement’ experienced by physically inactive women to develop policy and practice that can attend to this issue. The theory of reflexive embodiment, rooted in the interactionist tradition, provides the theoretical underpinning for the work as it highlights how women's bodies are influenced by the gaze of others. Results demonstrate that women feel judged for the way their bodies look and move during exercise, for prioritising physical activity over family duties, and that these sensations are influenced by the networks of people in activity spaces. The impact of judgement affects women's mental and physical wellbeing. It leads to the cessation of physical activity, creates worries about restarting various forms of activity and shapes how and where women undertake exercise.
CHALLENGING THE FATE OF PERSISTENT ORGANIC POLLUTANTS
Creators: name: Singh, Neelu
name: VARTIKA SINGH
Publisher: name: figshare
Year: 2013
Subjects: Environmental Chemistry

description: The green revolution beginning during the late 1960s resulted in a quantum jump in agriculture production the world-over. Indiscriminate and inappropriate use of chemical fertilizers and pesticides to boost the agriculture production has done more harm to the environment and especially to the human health than could have been envisaged when they were first introduced. Persistent Organic Pollutants (POPs) concentrate on different forms this is one of the characteristics which has earned them the sobriquet of pollutants. In this article, we review the present nature of our knowledge on the POPs in India as well as internationally including the response of our country towards POPs convention. The article also highlights the need for a holistic research on the source-to-sink aspects of these compounds.
ENHANCING SECURITY WITH PERFORMANCE OF AODV ROUTING PROTOCOL FOR MOBILE AD HOC NETWORKS.
Creators: name: Viral. D.Patel
name: JWALANTBARIA
Publisher: name: figshare
Year: 2013
Subjects: Biotechnology

description: In MANETs (Mobile Ad-hoc Networks), there is nothing like central infrastructure to monitor or manage the resources used by the mobile nodes. MANET poses various kinds of security problems, caused by their nature of collaborative and open systems and by limited availability of resources. The absence of any central coordinator makes the routing a complex one compared to traditional networks. The AODV (Ad-hoc On-Demand Distance Vector) routing protocol is designed for ad hoc mobile nodes. AODV uses an on demand approach for finding the paths. In this work I have take a look at AODV in detail, study and analyses various attacks that can be possible on it. Then I study some proposed mechanisms for securing AODV routing protocol. My proposed work is to the secure AODV protocol with Double Signature mechanism which includes Secure Hash algorithm aimed at improving normal AODV performance. In my work I am going to propose an extension to the secure AODV protocol which includes secure hash algorithm aimed at further improving its security with network performance. I will analyze how my proposed secure encryption algorithm can help in further improvement of security and performance in AODV and also I will compare its performance with existing secure mechanisms using simulation in Network Simulator 2.
title: How to Undermine a Fundamental Norm: the Prohibition of the Use of Force in Light of the 2023 G20 Summit Outcome Document: Völkerrechtliche Tagesthemen 45
Creators: name: Grimmig, Alexander
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 341

description: In this episode of the Völkerrechtliche Tagesthemen, the speaker, Alexander Grimmig, takes a look at the 2023’s G20 summit outcome document and comparing it to the previous year. The speaker focuses on how the G20 addressed the Russo-Ukraine war and how it shifted from condemning Russia’s aggression in 2022 to then not mentioning Russia in any meaningful way in 2023. Grimmig then analyzes and contextualizes this very change of position considering the fundamental norm of the prohibition of the use of force.
description: Völkerrechtsblog
Nutritional balance of corn chips (inferential statistics) (2e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Medicine

description: Perezgonzalez assessed the nutritional balance of corn chips in 2012, as part of a research on the nutritional composition of snacks in New Zealand. The population of corn chips appears as extremely unbalanced. Indeed, it can be inferred, with a 95% degree of confidence, that the median nutritional balance is located somewhere between BNI 76.67 and BNI 88.63, and the mean sensibly lower, somewhere between BNI 53.17 and BNI 63.07. Similar nutritional profiles appear when using other international recommended dietary intakes (RDIs), as well. Indeed, the correlation between indexes is very high. These correlations would occur by chance less than one in 1000, thus it can be inferred that they truly reflect an underlying relationship between international indexes. (Also retrievable from Wiki of Science.)
The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile
Creators: name: Berthelet, Jean
name: Wimmer, VC
name: Whitfield, HJ
name: Serrano, Antonin
name: Boudier, T
name: Mangiola, S
name: Merdas, Michal Stanislaw
name: El-Saafin, Farrah
name: Baloyan, David
name: Wilcox, Jordan
name: Wilcox, S
name: Parslow, Adam
name: Papenfuss, AT
name: Yeo, Belinda
name: Ernst, Matthias
name: Pal, Bhupinder
name: Anderson, Robin
name: Davis, Martine
name: Rogers, KL
name: Hollande, F
name: Merino, Delphine
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in this process remains unclear. Here, we optimized the use of optical barcoding to visualize and characterize 31 cancer subclones in vivo. By mapping the clonal composition of thousands of metastases in two clinically relevant sites, the lungs and liver, we found that metastases were highly polyclonal in lungs but not in the liver. Furthermore, the transcriptome of the subclones varied according to their metastatic niche. We also identified a reversible niche-driven signature that was conserved in lung and liver metastases collected during patient autopsies. Among this signature, we found that the tumor necrosis factor–α pathway was up-regulated in lung compared to liver metastases, and inhibition of this pathway affected metastasis diversity. These results highlight that the cellular and molecular heterogeneity observed in metastases is largely dictated by the tumor microenvironment.
Referential NZD based on CPI (2012e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Referential NZD provides the inflator/deflator multiplier for standardizing New Zealand dollars (within the philosophy of referential currencies). It is based on the average annual CPI for all groups (estimated from quarter inflation index values provided by the Reserve Bank of New Zealand). (Also retrievable from Wiki of Science.)
The challenges of partnering to promote health through sport
Creators: name: Donaldson, Alex
name: Staley, Kiera
name: Cameron, M
name: Dowling, S
name: Randle, Erica
name: O'Halloran, Paul
name: McNeil, Nicola
name: Stukas, Arthur
name: Nicholson, Matthew
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 35
subject: Commerce, management, tourism and services
classificationCode: 3504
subject: Commercial services
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Interagency partnerships and collaborations underpin a settings-based approach to health promotion in all settings, including sport. This study used an online concept mapping approach to explore the challenges that Regional Sports Assemblies (RSAs) in Victoria, Australia experienced when working in partnerships to develop and deliver physical activity programs in a community sport context. Participants from nine RSAs brainstormed 46 unique partnership-related challenges that they then sorted into groups based on similarity of meaning and rated for importance and capacity to manage (6-point scale; 0 = least, 5 = most). A six cluster map (number of statements in cluster, mean cluster importance and capacity ratings)—Co-design for regional areas (4, 4.22, 2.51); Financial resources (3, 4.00, 2.32); Localised delivery challenges (4, 3.72, 2.33); Challenges implementing existing State Sporting Association (SSA) products (9, 3.58, 2.23); Working with clubs (8, 3.43, 2.99); and Partnership engagement (18, 3.23, 2.95)—was considered the most appropriate interpretation of the sorted data. The most important challenge was Lack of volunteer time (4.56). Partnerships to implement health promotion initiatives in sports settings involve multiple challenges, particularly for regional sport organisations working in partnership with community sport clubs with limited human and financial resources, to implement programs developed by national or state-based organisations.