cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Modul A: Strukturierte Beratungsgespräche mit Studierenden führen: Rollenspiel
Creators: name: Friedrich-Schiller-Universität Jena, Zentrum Für Lehrerbildung Und Bildungsforschung
Publisher: name: Friedrich-Schiller-Universität Jena, Zentrum für Lehrerbildung und Bildungsforschung
Year: 2021
Subjects: subject: Ausbildung der Ausbilder
subject: Unterrichten: Lehren und Lernen
subject: Curriculum
subject: Strukturierte Beratungsgespräche
subject: Studierende – Mentor/innen
subject: Rollenspiel
subject: 370

description: Das Arbeitsmaterial „Rollenspiel“ gehört zum Curriculum Unterrichten: Lehren und Lernen des Projektes Ausbildung der Ausbilder (https://www.profjl.uni-jena.de/teilvorhaben/ausbildung+der+ausbilder+(auau)), richtet sich an Lehrpersonen, die Studierende in schulischen Praxisphasen begleiten (Experte-Novize-Modus) und ist Bestandteil des Moduls A strukturierte Beratungsgespräche mit Studierenden führen. In diesem Modul geht es darum, eine professionalisierte Beratungshaltung in Reflexionsgesprächen über Unterricht anzubahnen, die durch Empathie, Akzeptanz und Echtheit geprägt ist und Fehlformen der Beratung vermeidet. Daneben wird ein Modell für ein strukturiertes Beratungsgespräch vorgestellt. Die Strukturierung erfolgt (a) inhaltlich durch das gemeinsame Ermitteln von Beratungsschwerpunkten und (b) gesprächsorganisatorisch über sieben Phasen in einem Ablaufmodell. Das Arbeitsmaterial „Rollenspiel“ beinhaltet eine Anleitung für ein Rollenspiel zur Erprobung eines strukturierten Beratungsgesprächs und wird ergänzt durch ein Begleitheft, das alle Inhalte und theoretischen Hintergründe des Moduls umfasst, eine Power-Point-Präsentation, die für die Durchführung einer Fortbildung zu den Modulinhalten eingesetzt werden kann, einen Leitfaden, der Ziele und Ablauf der Fortbildung abbildet, sowie kurze Videoclips, die die Modulinhalte nochmals veranschaulichen. Das gesamte Curriculum enthält unterschiedliche Fassungen und Module. Damit Querverweise nachvollziehbar werden, wird empfohlen diese Datei im Kontext der ergänzenden Materialien zu verwenden. Copyright 2021. Alle Rechte vorbehalten. Gerne stellen wir Ihnen unsere Materialien kostenfrei zur Verfügung unter den folgenden Voraussetzungen: Alle Materialien sind nach den gesetzlichen Bestimmungen urheberrechtlich geschützt. Materialien, die aufgrund ihrer Beschaffenheit eine Bearbeitung ausdrücklich zulassen, dürfen durch Nutzer/innen bearbeitet oder übersetzt werden. Alle anderen Materialien und Medien dürfen nur unbearbeitet genutzt werden. Wir bitten bei der Verwendung der Materialien um einen Hinweis auf die Herausgeber/innen. Wir sind interessiert an Ihrer Rückmeldung zu den Materialien und deren Einsatz. Dies hilft uns bei deren Evaluation und Weiterentwicklung. Nutzen Sie hierzu gerne unseren kurzen Online-Fragebogen (https://ww2.unipark.de/uc/unterrichtenlehrenundlernen/) oder schreiben Sie uns eine E-Mail (maya.zastrow@uni-jena.de). Wir freuen uns auf Ihr Feedback.
description: Unterrichten: Lehren und Lernen - Materialien für Praxisphasen im Studium (1. Phase), Modul A: Strukturierte Beratungsgespräche mit Studierenden führen
Searches for Anisotropies in the Arrival Directions of the Highest Energy Cosmic Rays Detected by the Pierre Auger Observatory
Creators: name: Pierre Auger Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We analyze the distribution of arrival directions of ultra-high energy cosmic rays recorded at the Pierre Auger Observatory in 10 years of operation. The data set, about three times larger than that used in earlier studies, includes arrival directions with zenith angles up to $80^\circ$, thus covering from $-90^\circ$ to $+45^\circ$ in declination. After updating the fraction of events correlating with the active galactic nuclei (AGNs) in the Véron-Cetty and Véron catalog, we subject the arrival directions of the data with energies in excess of 40 EeV to different tests for anisotropy. We search for localized excess fluxes and for self-clustering of event directions at angular scales up to $30^\circ$ and for different threshold energies between 40~EeV and 80~EeV. We then look for correlations of cosmic rays with celestial structures both in the Galaxy (the Galactic Center and Galactic Plane) and in the local Universe (the Super-Galactic Plane). We also examine their correlation with different populations of nearby extragalactic objects: galaxies in the 2MRS catalog, AGNs detected by Swift-BAT, radio galaxies with jets and the Centaurus~A galaxy. None of the tests shows a statistically significant evidence of anisotropy. The strongest departures from isotropy (post-trial probability ${\sim}1.4$\%) are obtained for cosmic rays with $E>58$~EeV in rather large windows around Swift AGNs closer than 130~Mpc and brighter than $10^{44}$~erg/s (18$^\circ$ radius) and around the direction of Centaurus~A (15$^\circ$ radius).
description: Replaced with published version. Added Journal reference and DOI
“When you get the HPV vaccine, it will prevent cervical cancer; it will act as a shield”: adolescent girls’ knowledge and perceptions regarding the human papillomavirus vaccine in Zambia
Creators: name: Kawonga, Mary
name: Lubeya, Mwansa Ketty
name: Frank, Simone
name: Chibwesha, Carla J.
name: Mukosha, Moses
name: Mwanahamuntu, Mulindi
Publisher: name: Frontiers Media SA
Year: 2023

description: Introduction The human papillomavirus (HPV) vaccination is an important preventive measure for HPV-related conditions such as cervical cancer. In 2019, Zambia introduced a free national HPV vaccination program for 14-year-old girls. However, the adolescents’ knowledge and perceptions regarding the HPV vaccine are not well understood. Therefore, this study aimed to understand adolescent girls’ knowledge and perceptions regarding the HPV vaccine and discuss its acceptability and uptake implications. Methods We conducted a qualitative study in the Lusaka district between June 2021 and November 2021 using semi-structured interviews with adolescent girls aged 15–18 years regardless of their HPV vaccination status. Interviews were transcribed verbatim, and NVIVO 12 was used for data management and analysis. We coded transcripts deductively and inductively based on emerging themes. Perceptions were coded using the health belief model constructs. Results We interviewed 30 adolescent girls to reach saturation. Seventeen girls reported having received at least one dose of the HPV vaccine. Participants expressed variable knowledge and awareness about HPV and the HPV vaccine. Participants exhibited positive attitudes towards the HPV vaccine and perceived it as beneficial. However, there were multiple perceived barriers to vaccination, such as the need for parental consent, not being in school, concerns about vaccine side effects, and belief in myths and misinformation. Conclusion The adolescent girls in this study showed variable knowledge and positive attitudes toward the HPV vaccine despite the many perceived barriers. To support increased HPV vaccine acceptability and uptake among adolescent girls in Zambia, it is critical to actively engage stakeholders involved in HPV vaccination, such as adolescents and their parents, and debunk myths and misconceptions about HPV vaccination. Health education in schools and communities should be implemented to increase knowledge about HPV and HPV vaccination among adolescents and their parents.
Formulation, pharmacokinetics and pharmacodynamics of topical microbicides
Creators: name: Kashuba, Angela D.M.
name: Adams, Jessica L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The development of safe topical microbicides that effectively prevent human immunodeficiency virus (HIV) infection is a major goal in curbing the human immunodeficiency virus pandemic. A number of past failures resulting from mucosal toxicity or lack of efficacy have informed the field. Products that caused toxicity to the female genital tract mucosa, and thereby increased the likelihood of HIV acquisition, included nonoxynol 9, cellulose sulfate, and C31 G vaginal gel Savvy®. Topical products that were ineffective in preventing HIV infection include BufferGel®, Carraguard®, and PRO 2000®. Antiretroviral drugs such as tenofovir and dapivirine formulated into microbicide products have shown promise, but there is much to learn about ideal product formulation and acceptability, and drug distribution and disposition (pharmacokinetics). Current formulations for water-soluble molecules include vaginally or rectally applied gels, vaginal rings, films and tablets. Dosing strategies (e.g. coitally dependent or independent) will be based on the pharmacokinetics of the active ingredient and the tolerance for less than perfect adherence.
A homozygous missense variant in the YG box domain in an individual with severe spinal muscular atrophy: a case report and variant characterization
Creators: name: Fan, Zheng
name: Hunter, Senyene E.
name: Sneddon, Tam P.
name: Shiloh-Malawsky, Yael
name: Li, Leping
name: Perera, Lalith
name: Varghese, Sonia A.
name: Powell, Cynthia M.
name: Matera, A. Gregory
Publisher: name: Frontiers Media SA
Year: 2023

description: The vast majority of severe (Type 0) spinal muscular atrophy (SMA) cases are caused by homozygous deletions of survival motor neuron 1 (SMN1). We report a case in which the patient has two copies of SMN1 but clinically presents as Type 0 SMA. The patient is an African American male carrying a homozygous maternally inherited missense variant (c.796T>C) in a cis-oriented SMN1 duplication on one chromosome and an SMN1 deletion on the other chromosome (genotype: 2*+0). Initial extensive genetic workups including exome sequencing were negative. Deletion analysis used in the initial testing for SMA also failed to detect SMA as the patient has two copies of SMN1. Because of high clinical suspicion, SMA diagnosis was finally confirmed based on full-length SMN1 sequencing. The patient was initially treated with risdiplam and later gene therapy with onasemnogene abeparvovec at 5 months without complications. The patient’s muscular weakness has stabilized with mild improvement. The patient is now 28 months old and remains stable and diffusely weak, with stable respiratory ventilatory support. This case highlights challenges in the diagnosis of SMA with a non-deletion genotype and provides a clinical example demonstrating that disruption of functional SMN protein polymerization through an amino acid change in the YG-box domain represents a little known but important pathogenic mechanism for SMA. Clinicians need to be mindful about the limitations of the current diagnostic approach for SMA in detecting non-deletion genotypes.
The long-term psychiatric and medical prognosis of perinatal mental illness
Creators: name: Meltzer-Brody, Samantha
name: Stuebe, Alison
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The perinatal period provides an important window into a woman’s long-term health. Perinatal mental illness is a common condition conferring potential serious long-term psychiatric and medical consequences for the mother and family. It is known that childbirth acts as a powerful trigger for depressive episodes in some women, and that women with histories of a mood disorder are particularly vulnerable. Some evidence links perinatal mental illness with obstetrical complications and reduced lactation initiation and duration. Therefore, perinatal mental illness may be a marker for long-term risk, and may contribute directly to subsequent cardiometabolic disease through both neuroendocrine mechanisms and the effects of mental illness on health behaviours. In clinical practice, these associations underscore the importance of screening and treating women with perinatal mental illness to ensure best possible long-term outcomes. Early screening and treatment may both mitigate the primary disease process and reduce the risk of comorbid medical conditions.
A Taxonomy of Externalization Policies
Creators: name: Rausis, Frowin
name: Lavenex, Sandra
Publisher: name: Zenodo
Year: 2024

description: While we have witnessed a flurry of research on the history, politics, and legality of externalization policies, conceptual work has been relatively scarce. Against this backdrop, we put forward a taxonomy of externalization policies, distinguishing the spaces in which states aim to control human movements and limit their legal obligations towards people seeking protection as well as the means by which states exercise power. Essentially, states have strived to control territorial space through physical obstacles and digital innovation; legal space through policies of inadmissibility and practices of irresponsibility; diplomatic space through bilateral and multilateral cooperation; and influence mobility aspirations by targeting the mental space of potential migrants. The evolution of these four layers of refugee externalization implies supplementing biopolitics based on external migration control measures with transnational psychopolitics based on communicative strategies aiming to disincentivize departure by internalizing control.

Published in online compendium “Externalizing Asylum: A Compendium of Scientific Knowledge” on 25 June 2024, https://externalizingasylum.info/a-taxonomy-of-externalization-policies/

A shorter version of this article was published in the “Forced Migration Studies Blog” (FluchtforschungsBlog) on 9 July 2024, https://fluchtforschung.net/a-taxonomy-of-externalization-policies/
title: Nitrification Potential in Arid Western Soils
Creators: name: Patel, Hasumati R.
Publisher: name: Utah State University
Year: 1972

description: Nitrification rates were determined by perfusion method in Southern Curlew Valley (Utah) soils from 0 to 1.3 meter profiles as a function of seasons. Ammonification rates were determined at various moisture contents and seasonal variations of ammonium concentration in the same soils were estimated.
Rate of nitrification was higher in warm showery periods (May and June) than in colder periods (September, October and November). In the top 3 cm layer, nitrifying activity was several fold higher than in the rest of the profile. Cultivation increased the nitrification rate.
Considerable ammonium fixation by soil particles, volatilazation of ammonia and nitrite accumulation were evident. Nitrite accumulated in samples as the pH of perfusate increased above 7.8. Accumulation of nitrate had a 8-10 days lag period, which was followed by a logarithmic phase. Nitrification was inhibited by added amendments, especially by desert plant litter.
Ammonium-nitrogen values in soils were between 1-105 ppm, with higher values in later fall (November) samples. Top 3 cm layers showed higher ammonium-nitrogen values than other (5-20, 40-50, 70-80, and 110-130cm) layers.
Ammonification rate increased with increasing in soil moisture in casein amended soils. Moisture content did not significantly affect ammonification in litter amended soils. Volatilization of ammonia was highest at 40% water-holding capacity (W. H. C.). Volatilization decreased with increase or decrease in moisture content above or below 40% W. H. C.
“They have their own people”: Emotional connections, community belonging, and Chinese gay, bisexual and other men who have sex with men (GBMSM) college students’ needs for sexual health support
Creators: name: Li C.
name: Tang K.
name: Liang Y.
name: Zhang R.
name: Zou K.
name: Yang M.
Publisher: name: Public Library of Science
Year: 2023

description: Gay, bisexual and other men who have sex with men (GBMSM) college students in China have unique sexual health challenges, including a higher risk of HIV infection, stigma and discrimination against LGBTQ (lesbian, gay, bisexual, transgender, and queer) population, and limited access to LGBTQ-affirmative sexual health support. Nonetheless, previous research or policymaking has rarely addressed the students’ needs for sexual health support from their perspectives. This study aims to explore GBMSM college students’ perceptions and attitudes to current sexual health resources, the challenges they encounter, and their expectations to acquiring LGBTQ-affirmative sexual health information and services. The exploration was carried out through field visits and in-depth interviews with 26 GBMSM college students and eight relevant stakeholders in five cities in China. Qualitative thematic analysis was applied to the interview transcripts and fieldwork memos. Four themes emerged around the preference and needs of GBMSM students in dealing with their sexual health challenges: the association between tackling sexual health challenges and entering LGBTQ communities, the roles of emotional attachment in shaping the preference for HIV-related care and support, the desired modes of acquiring sexual health support, and the current unmet service needs. We discovered that the information-and-care-seeking behaviors of GBMSM college students are highly influenced by and connected to their participation in online and in-person LGBTQ communities. Due to the overall stigmatizing sociocultural environment of LGBTQ in China, GBMSM college students tend to rely on LGBTQ communities, seeking trust and a sense of belongingness for tackling their sexual health challenges. Conventional school-based sexual health educational programs, which often apply top-down, stigma-and-fear-based, and non-LGBTQ-inclusive teaching strategies, rarely help GBMSM college students to solve sexual health problems in real life. GBMSM college students are eager to have LGBTQ-affirmative "health managers" who can understand their emotional experiences and interpersonal contexts and assist them with sexual health issues. However, such support is generally perceived as limited by the students. Our study highlights these unmet needs of the GBMSM students and emphasizes the importance of developing future LGBTQ-affirmative sexual health programs among Chinese GBMSM college students and young GBMSM in general.
Physical exercise as non-pharmacological treatment of chronic pain: Why and when
Creators: name: Ambrose, Kirsten R.
name: Golightly, Yvonne M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Chronic pain broadly encompasses both objectively defined conditions and idiopathic conditions that lack physical findings. Despite variance in origin or pathogenesis, these conditions are similarly characterized by chronic pain, poor physical function, mobility limitations, depression, anxiety and sleep disturbance and are treated alone or in combination by pharmacologic and nonpharmacologic approaches, such as physical activity (aerobic conditioning, muscle strengthening, flexibility training and movement therapies). Physical activity improves general health, disease risk and progression of chronic illnesses such as cardiovascular disease, type-2 diabetes and obesity. When applied to chronic pain conditions within appropriate parameters (frequency, duration, intensity), physical activity significantly improves pain and related symptoms. For chronic pain, strict guidelines for physical activity are lacking, but frequent movement is preferable to sedentary behavior. This gives considerable freedom in prescribing physical activity treatments, which are most successful when tailored individually, progressed slowly and account for physical limitations, psychosocial needs and available resources.
IPBES invasive alien species assessment, data management report for Chapter 3. Section 3.3.1.1: Intentional or unintentional introductions from the use of alien species in terrestrial and marine bioproduction systems
Creators: name: Vandvik, Vigdis
name: Ikeda, Tohru
Publisher: name: Zenodo
Year: 2023
Subjects: Data management report

description: Section 3.3.1.1 assesses the role of intentional or unintentional introductions from the use of alien species in terrestrial and marine bioproduction systems as drivers of biological invasions. The experts conducted a systematic review to report on the existing knowledge on this driver. This systematic review consists in the main source of evidence for the section.
Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots
Creators: name: Delmore, Paula
name: Gonzalez, Daniel
name: Benjamin, Daniel K
name: Mendley, Susan R
name: Lewandowski, Andrew
name: Delinsky, Amy
name: Sullivan, Janice E
name: Harper, Barrie
name: Melloni, Chiara
name: Yogev, Ram
name: Zimmerman, Kanecia
name: Poindexter, Brenda B
name: Lewis, Kenneth C
name: Atz, Andrew M
name: Cohen-Wolkowiez, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Trimethoprim-sulfamethoxazole (TMP-SMX) is an antimicrobial drug combination commonly prescribed in children and adults. The study objectives were to validate and apply an HPLC–MS/MS method to quantify TMP-SMX in dried plasma spots (DPS) and dried urine spots (DUS), and perform a comparability analysis with liquid matrices.
Three-edge-colouring doublecross cubic graphs
Creators: name: Edwards, Katherine
name: Sanders, Daniel P.
name: Seymour, Paul
name: Thomas, Robin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: A graph is apex if there is a vertex whose deletion makes the graph planar, and doublecross if it can be drawn in the plane with only two crossings, both incident with the infinite region in the natural sense. In 1966, Tutte conjectured that every two-edge-connected cubic graph with no Petersen graph minor is three-edge-colourable. With Neil Robertson, two of us showed that this is true in general if it is true for apex graphs and doublecross graphs. In another paper, two of us solved the apex case, but the doublecross case remained open. Here we solve the doublecross case; that is, we prove that every two-edge-connected doublecross cubic graph is three-edge-colourable. The proof method is a variant on the proof of the four-colour theorem.
description: 16 pages, 1 figure, 1 appendix. Three results in this paper are proved using computers. Please see version 1 for the computer programs and associated data
Enzymatic synthesis of heparin related polysaccharides on sensor chips: Rapid screening of heparin–protein interactions
Creators: name: Kemp, Melissa
name: Muñoz, Eva
name: Linhardt, Robert J.
name: Liu, Jian
name: Xu, Ding
name: Avci, Fikri
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The biological roles of heparin (HP) and heparan sulfate (HS) are mediated mainly through their interaction with proteins. In the present work, we provide a rapid method for screening HP/HS–protein interactions providing structural data on the key sulfo groups that participate in the binding. A library of polysaccharides structurally related to HP was prepared by immobilizing the biotinylated N-sulfated K5 polysaccharide (N-sulfoheparosan) on sensor chips followed by selective modification of this polysaccharide with enzymes that participate in HP/HS biosynthesis. The polysaccharides synthesized on the surface of the sensor chips differ in the number and position of sulfo groups present both on uronic acid and glucosamine residues. Surface plasmon resonance was used to measure the interaction of each member of this polysaccharide library with antithrombin III (ATIII), to afford structural information on sulfo groups required for this HP/HS–protein interaction. This method is viewed as widely applicable for the study of the structure–activity relationship (SAR) of HP/HS–protein interactions.
Post-translational modifications of collagen upon BMP-induced osteoblast differentiation
Creators: name: Mochida, Yoshiyuki
name: Atsawasuwan, Phimon
name: Kaku, Masaru
name: Parisuthiman, Duenpim
name: Yamauchi, Mitsuo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The pattern of collagen cross-linking is tissue specific primarily determined by the extent of hydroxylation and oxidation of specific lysine residues in the molecule. In this study, murine pre-myoblast cell line, C2C12 cells, were transdifferentiated into osteoblastic cells by bone morphogenetic protein (BMP)-2 treatment, and the gene expression of lysyl hydroxylases (LH1, 2a/b and 3) and lysyl oxidase (LOX)/lysyl oxidase-like proteins (LOXL1–4), and the extent of hydroxylysine were analyzed. After 24 hours of treatment, the expression of most isoforms were upregulated up to 96 hours whereas LH2a and LOXL2 decreased with time. In the treated cells, both hydroxyproline and hydroxylysine were detected at day 7 and increased at day 14. The ratio of hydroxylysine to hydroxyproline was significantly increased at day 14. The results indicate that LHs and LOX/LOXLs are differentially responsive to BMP-induced osteoblast differentiation that may eventually lead to the specific collagen cross-linking pattern seen in bone.
Optimization Problems in Correlated Networks
Creators: name: Yang, Song
name: Trajanovski, Stojan
name: Kuipers, Fernando A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Solving the shortest path and the min-cut problems are key in achieving high performance and robust communication networks. Those problems have often beeny studied in deterministic and independent networks both in their original formulations as well as in several constrained variants. However, in real-world networks, link weights (e.g., delay, bandwidth, failure probability) are often correlated due to spatial or temporal reasons, and these correlated link weights together behave in a different manner and are not always additive. In this paper, we first propose two correlated link-weight models, namely (i) the deterministic correlated model and (ii) the (log-concave) stochastic correlated model. Subsequently, we study the shortest path problem and the min-cut problem under these two correlated models. We prove that these two problems are NP-hard under the deterministic correlated model, and even cannot be approximated to arbitrary degree in polynomial time. However, these two problems are polynomial-time solvable under the (constrained) nodal deterministic correlated model, and can be solved by convex optimization under the (log-concave) stochastic correlated model.
description: 11 pages, 10 figures, accepted for publication in Computational Social Networks, Springer
Urban Air Mobility: Safety Aspects for a New Era of Sustainable Aviation
Creators: name: Müller, Jörg P.
Publisher: name: Zenodo
Year: 2022
Subjects: UAM
mobility
aircraft
aviation
Airbus
city
CityAirbus
demonstrator
prototype
VTOL
eVTOL
safety
accident
regulation
lift
thrust
validation
airframe
structure
transportation
aerolectures
aerolectures2022

description: Urban Air Mobility is at the juncture where the ever growing societal need for efficient and sustainable transport meets new solutions provided by emerging technology. The lecture provides the rationale for this new and sustainable way of flying in cities and beyond. It describes the state of the art, and in particular Airbus’ positioning with CityAirbus NextGen. In that sense, UAM is much broader than just a flying vehicle. It requires infrastructure on the round, an adapted airspace management, and an efficient integration with complementary means of transport. Furthermore, the introduction of a new means of transport requires that highest safety standards are met. The new eVTOL architectures and mission profiles call for new approaches to safety of the vehicles in their operational environment. Therefore, the second part of the lecture provides an overview on Airbus’ approach to safety and particular aspects concerning the distributed electric propulsion system, flight controls and aerostructures.
description: Hamburg Aerospace Lecture Series --- Collection of Presentations --- http://www.AeroLectures.de --- Annual Gerhard Sedlmayr Lecture
A Portable Nanoporous Gold Modified Screen-Printed Sensor for Reliable and Simultaneous Multi-Vitamins Analysis
Creators: name: Gao X.
name: Liu H.
name: Chen S.
name: Wang X.
name: Wang X.
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: Despite being present in minimal amounts, vitamin B2 (VB2), vitamin C (VC), and vitamin B6 (VB6) each play indispensable roles in human metabolisms. Given that VB2, VC, and VB6 cannot be synthesized by the human body, detections of these three vitamins both in fermentation liquid where vitamins are industrially manufactured and in human serum where vitamin concentrations could be clinically controlled are of significant importance. Here, a nanoporous gold (NPAu) modified screen-printed electrode (NPAu/SPE) was fabricated to detect VB2, VC, and VB6 based on NPAu’s electro-oxidation towards vitamins. Owing to the wide separation of peak potentials among VB2, VC, and VB6, the simultaneous detection of these three vitamins was achieved by the NPAu/SPE within a potential range from −0.8 V to 0.8 V. The achieved limits of detection (LOD) for VB2, VC, and VB6 were 0.46, 6.44, and 1.92 μM, with sensitivities of 68.58, 4.77, and 15.94 μA/μM, respectively. Subsequent reliability experiments suggested that the NPAu/SPE exhibited solid anti-interference capability and repeatability. Additionally, the real-sample detection of the NPAu/SPE towards VB2, VC, and VB6 was achieved both in human serum and in fermentation liquid with comparable accuracy (the recovery rates were from 89.8% to 111.7%) as high-performance liquid chromatography (HPLC). Moreover, the portable NPAu/SPE showed comparable performance in terms of the LOD and linear dynamic range when compared to glassy carbon electrodes (GCE) limited to laboratory detection. The proposed NPAu/SPE possesses various advantageous properties including portability, easy fabrication, high sensitivity, and cost-efficiency, making it a potential candidate for clinical and industrial multi-vitamins analysis.
Zum Andenken an Johann Friedrich Peyer im Hof
Creators: name: Geiser, Friedrich
Publisher: name: Buchdruckerei der Neuen Zürcher Zeitung
Year: 1900
Subjects: subject: 320 Politikwissenschaft
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Peyer im Hof, Friedrich
subject: Schaffhausen
subject: Zürich

description: Separatdruck aus der Neuen Zürcher Zeitung
Assessing the size and growth of the US wetland and stream compensatory mitigation industry
Creators: name: Kwon, Joungwon
name: BenDor, Todd K.
name: Lester, T. William
Publisher: name: Public Library of Science
Year: 2023

description: Interest has focused on quantifying the size and scope of environmental markets, particularly those that offset ecosystem impacts or restore natural infrastructure to improve habitat or promote clean air and water. In this paper, we focus on the US wetland and stream compensatory mitigation market, asking: what types of firms make up the mitigation “industry”? What are the economic impacts–i.e., the “size”–of the mitigation industry? How has this industry changed over time? We present the results of a national survey of mitigation firms and construct an input-output model of the industry’s economic impacts and employment. We also develop a comparative, 2014 model of the industry using data from a previous study of the broader, ecological restoration economy. Our findings suggest that the (2019, pre-COVID) mitigation industry collects annual revenues (direct economic impacts) in excess of $3.5 billion, which, along with additional indirect (supply chain) and induced (spillover) economic impacts, combine to over $9.6 billion in total output and support over 53,000 total jobs. We estimate 2014–2019 growth of ~35.2 percent in revenues, ~32.6 percent in total economic impacts, and a compound annual growth rate (CAGR) of 5.25%. This places the mitigation industry within the range of other, well-established industries within the technical services sector. We suggest establishing North American Industry Classification System (NAICS) codes specifically for ecological restoration and mitigation firms, an essential step in generating accurate and consistent employment estimates in the future, particularly at sub-national geographic scales.
Contact V Knowledge RPS Study
Creators: name: Cheso, Diana
name: Zagefka, Hanna
name: Bjornsdottir, R. Thora
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Sociology
subject: FOS: Sociology
subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: Gender and Sexuality

description: This study will test the extent to which contact with and knowledge about transgender individuals and experiences influence feelings and attitudes towards transgender people in general.
Contact and Knowledge Replication Study
Creators: name: Cheso, Diana
name: Zagefka, Hanna
name: Bjornsdottir, R. Thora
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Personality and Social Contexts
subject: Social Psychology
subject: Social Psychology and Interaction
subject: Gender and Sexuality
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: This is largely a replication study that will test whether contact mediates the relationship between knowledge and transprejudice.
Wave Optics in Black Hole Spacetimes: Schwarzschild Case
Creators: name: Nambu, Yasusada
name: Noda, Sousuke
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We investigate the wave optics in the Schwarzschild spacetime. Applying the standard formalism of wave scattering problems, the Green function represented by the sum over the partial waves is evaluated using the Poisson sum formula. The effect of orbiting scattering due to the unstable circular orbit for null rays is taken into account as the contribution of the Regge poles of the scattering matrix and the asymptotic form of the scattering wave is obtained in the eikonal limit. Using this wave function, images of the black hole illuminated by a point source are reconstructed. We also discuss the wave effect in the frequency domain caused by the interference between the direct rays and the winding rays.
description: 23 pages, to be published in CQG
Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1
Creators: name: Coffey A.R.
name: Whitworth C.P.
name: Chitrakar A.
name: Bosque A.
name: Selitsky S.R.
name: Garrido C.
name: Samir S.
name: Soriano-Sarabia N.
name: Goonetilleke N.
name: Parker J.S.
name: Xu Y.
name: Tsai Y.H.
name: Mann B.T.
name: Iannone M.A.
name: Weideman A.M.K.
name: Clohosey M.L.
name: Ward A.R.
name: Kirchherr J.
name: Sanz M.
name: Garcia-Recio S.
name: Copertino D.
name: Hudgens M.G.
name: Jones B.R.
Publisher: name: Frontiers Media SA
Year: 2023

description: Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts to cure HIV-1 infection include “shock and kill” strategies to disrupt latency using small molecules or latency-reversing agents (LRAs) to induce expression of HIV-1 enabling cytotoxic immune cells to eliminate infected cells. The modest success of current LRAs urges the field to identify novel drugs with increased clinical efficacy. Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. Here, we show the use of N-BPs as a novel class of LRA: we found in ex vivo assays using primary cells from ART-suppressed people living with HIV-1 that N-BPs induce HIV-1 from latency to levels that are comparable to the T cell activator phytohemagglutinin (PHA). RNA sequencing and mechanistic data suggested that reactivation may occur through activation of the activator protein 1 signaling pathway. Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. Decay of the reservoir measured by IPDA was however not detected. Our results demonstrate the novel use of N-BPs to reverse HIV-1 latency while inducing immune effector functions. This preliminary evidence merits further investigation in a controlled clinical setting possibly in combination with therapeutic vaccination.
Social consensus and tipping points with opinion inertia
Creators: name: Doyle, C.
name: Sreenivasan, S.
name: Szymanski, B. K.
name: Korniss, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: When opinions, behaviors or ideas diffuse within a population, some are invariably stickier than others. The stickier the opinion, behavior or idea, the greater is an individual's inertia to replace it with an alternative. Here we study the effect of stickiness of opinions in a two-opinion model, where individuals change their opinion only after a certain number of consecutive encounters with the alternative opinion. Assuming that one opinion has a fixed stickiness, we investigate how the critical size of the competing opinion required to tip over the entire population varies as a function of the competing opinion's stickiness. We analyze this scenario for the case of a complete-graph topology through simulations, and through a semi-analytical approach which yields an upper bound for the critical minority size. We present analogous simulation results for the case of the Erdős-Rényi random network. Finally, we investigate the coarsening properties of sticky opinion spreading on two-dimensional lattices, and show that the presence of stickiness gives rise to an effective surface tension that causes the coarsening behavior to become curvature-driven.
description: final version, reflecting changes in response to referees' comments
Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation
Creators: name: Hartle, Lauren
name: Yang, Fan
name: Son, Sun Mi
name: Xu, Qiaobing
name: Anderson, Daniel G.
name: Cho, Seung-Woo
name: Langer, Robert
name: Goldberg, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: RNA interference (RNAi) for anti-angiogenic or pro-apoptotic factors in endothelial cells (ECs) has great potential for the treatment of ischemic diseases by promoting angiogenesis or inhibiting apoptosis. Here, we report the utility of small interfering RNA (siRNA) in inhibiting EC apoptosis induced by tumor necrosis factor-α (TNF-α). siRNA was designed and synthesized targeting tumor necrosis factor-α receptor-1 (TNFR-1) and Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1). Human umbilical vein endothelial cells (HUVECs) were cultured under in vitro hypoxic and serum-deprived conditions to simulate in vivo ischemic conditions. Two days after liposomal delivery of siRNA targeting TNFR-1 and SHP-1, significant silencing of each target (TNFR-1; 76.5 % and SHP-1; 97.2 %) was detected. Under serum-deprived hypoxic (1% oxygen) conditions, TNF-α expression in HUVECs increased relative to normoxic (20% oxygen) and serum-containing conditions. Despite enhanced TNF-α expression, suppression of TNFR-1 or SHP-1 by siRNA delivery not only enhanced expression of angiogenic factors (KDR/Flk-1 and eNOS) and anti-apoptotic factor (Bcl-xL) but also reduced expression of a pro-apoptotic factor (Bax). Transfection of TNFR-1 or SHP-1 siRNA significantly decreased the HUVEC apoptosis while significantly enhancing HUVEC proliferation and capillary formation. The present study demonstrates that TNFR-1 and SHP-1 may be useful targets for the treatment of myocardial or hindlimb ischemia.
Experiences with NOMMU Linux for RISC-V platform bring-up and validation
Creators: name: Marazakis, Manolis
name: Kossifidis, Nick
Publisher: name: Zenodo
Year: 2024

description: The RISER project aims to build accelerator and microserver systems based on RISC-V SoCs from ongoing European projects funded by the EuroHPC JU. Working with experimental hardware platforms requires substantial effort on verification and bring-up, including bare-metal tests aimed at the core, memory, and platform levels. Booting a full-blown Linux distribution greatly expands test coverage butalso complexity. We recommend starting with a bare-minimum kernel configuration, without networking and storage functions, and even opting for a no-MMU system configuration, to progressively expand test coverage. In this talk, we outline the features and limitations of no-MMU and summarize our practical experience in early-stage verification of RISC-V prototype platforms.
ATM/Chk2 and ATR/Chk1 Pathways Respond to DNA Damage Induced by Movento® 240SC and Envidor® 240SC Keto-Enol Insecticides in the Germarium of Drosophila melanogaster
Creators: name: Sekelsky J.
name: González-Marín B.
name: Calderón-Segura M.E.
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: DNA damage response (DDR) pathways in keto-enol genotoxicity have not been characterized, and few studies have reported genotoxic effects in non-target organisms. The present study shows that concentrations of 11.2, 22.4, 37.3 mg/L of Movento® 240SC and 12.3, 24.6, 41.1 mg/L of Envidor® 240SC for 72 h oral exposure induced DSBs by significantly increasing the percentage of γH2AV expression in regions 2b and 3 from the germarium of wild type females of Drosophila melanogaster Oregon R, compared to the control group (0.0 mg/L of insecticides), via confocal immunofluorescence microscopy. The comparison between both insecticides’ reveals that only the Envidor® 240SC induces concentration-dependent DNA damage, as well as structural changes in the germarium. We determined that the DDR induced by Movento® 240SC depends on the activation of the ATMtefu, Chk1grp and Chk2lok kinases by significantly increasing the percentage of expression of γH2AV in regions 2b and 3 of the germarium, and that ATRmei−29D and p53dp53 kinases only respond at the highest concentration of 37.3 mg/L of Movento® 240SC. With the Envidor® 240SC insecticide, we determined that the DDR depends on the activation of the ATRmei−29D/Chk1grp and ATMtefu/Chk2lok kinases, and p53dp53 by significantly increasing the percentage of expression of γH2AV in the germarium.
IPBES invasive alien species assessment, data management report for Chapter 3 Section 3.3.1.2: Fragmentation of ecosystems
Creators: name: Vandvik, Vigdis
name: Pergl, Jan
Publisher: name: Zenodo
Year: 2023
Subjects: Data management report

description: Section 3.3.1.2 assesses the role of spatial fragmentation of ecosystems as drivers of biological invasions. The experts conducted a systematic review to report on the existing knowledge on this driver. This systematic review consists in the main source of evidence for the section. Search 1 were conducted for the first order draft, then based on the external reviewer’s comment, additional Search 2 to 6 were conducted.
Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue
Creators: name: Chandrasekaran, Prakash
name: Samuelson, Lisa
name: Gerber, David A.
name: Walkup, Maggie H.
name: Wright, Natasha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Recent interest in the liver stem cell field has led to the identification and characterization of several hepatic progenitor cell populations from fetal and adult tissues. We isolated a hepatic progenitor cell from naïve adult liver and the current studies focus on differentiation and growth.
Hydrodroma rheophila Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrodromidae
Hydrodroma
Hydrodroma rheophila

description: Hydrodroma rheophila Cook, 1967
Records from the study area: Maharashtra—Cook (1967); Prasad (1974); Pešić & Ranga Reddy (2009).
Habitat: All kind of running waters, e.g. small streams, rivers and springs; probably a hyporheophilous species.
Distribution: India, Indonesia, Iran.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on pages 5-6, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Performance Evaluation of Evolutionary Algorithms for Analog Integrated Circuit Design Optimisation
Creators: name: Rashid, Ria
name: Raghunath, Gopavaram
name: Badugu, Vasant
name: Nambath, Nandakumar
Publisher: name: arXiv
Year: 2023
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: An automated sizing approach for analog circuits using evolutionary algorithms is presented in this paper. A targeted search of the search space has been implemented using a particle generation function and a repair-bounds function that has resulted in faster convergence to the optimal solution. The algorithms are tuned and modified to converge to a better optimal solution with less standard deviation for multiple runs compared to standard versions. Modified versions of the artificial bee colony optimisation algorithm, genetic algorithm, grey wolf optimisation algorithm, and particle swarm optimisation algorithm are tested and compared for the optimal sizing of two operational amplifier topologies. An extensive performance evaluation of all the modified algorithms showed that the modifications have resulted in consistent performance with improved convergence for all the algorithms. The implementation of parallel computation in the algorithms has reduced run time. Among the considered algorithms, the modified artificial bee colony optimisation algorithm gave the most optimal solution with consistent results across multiple runs.
Generalized Hamilton-Jacobi-Bellman equations with Dirichlet boundary and stochastic exit time optimal control problem
Creators: name: Buckdahn, Rainer
name: Nie, Tianyang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 60H10, 60H30

description: We consider a kind of stochastic exit time optimal control problems, in which the cost function is defined through a nonlinear backward stochastic differential equation. We study the regularity of the value function for such a control problem. Then extending Peng's backward semigroup method, we show the dynamic programming principle. Moreover, we prove that the value function is a viscosity solution to the following generalized Hamilton-Jacobi-Bellman equation with Dirichlet boundary: \[ \left\{ \begin{array} [c]{l} \inf\limits_{v\in V}\left\{\mathcal{L}(x,v)u(x)+f(x,u(x),\nabla u(x) σ(x,v),v)\right\}=0, \quad x\in D,\medskip\\ u(x)=g(x),\quad x\in \partial D, \end{array} \right. \] where $D$ is a bounded set in $\mathbb{R}^{d}$, $V$ is a compact metric space in $\mathbb{R}^{k}$, and for $u\in C^{2}(D)$ and $(x,v)\in D\times V$, \[\mathcal{L}(x,v)u(x):=\frac{1}{2}\sum_{i,j=1}^{d}(σσ^{\ast})_{i,j}(x,v)\frac{\partial^{2}u}{\partial x_{i}\partial x_{j}}(x) +\sum_{i=1}^{d}b_{i}(x,v)\frac{\partial u}{\partial x_{i}}(x). \]
description: 29 pages