cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology
Creators: name: Neuberger, James
name: Patel, Jai
name: Caldwell, Helen
name: Davies, Susan
name: Hebditch, Vanessa
name: Hollywood, Coral
name: Hubscher, Stefan
name: Karkhanis, Salil
name: Lester, Will
name: Roslund, Nicholas
name: West, Rebecca
name: Wyatt, Judith I
name: Heydtman, Mathis
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Guidelines
1506
2312
liver biopsy
histopathology
interventional radiology

description: Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles is available and the approach and type of needle used will depend on the clinical state of the patient and local expertise but, for non-lesional biopsies, a 16-gauge needle is recommended. Many patients with liver disease will have abnormal laboratory coagulation tests or receive anticoagulation or antiplatelet medication. A greater understanding of the changes in haemostasis in liver disease allows for a more rational, evidence-based approach to peri-biopsy management. Overall, liver biopsy is safe but there is a small morbidity and a very small mortality so patients must be fully counselled. The specimen must be of sufficient size for histopathological interpretation. Communication with the histopathologist, with access to relevant clinical information and the results of other investigations, is essential for the generation of a clinically useful report.
Fostering quality improvement for RSE projects through consulting offers
Creators: name: Förster, Thomas
Publisher: name: Zenodo
Year: 2023
Subjects: HIFIS
deRSE23
Consulting

description: To promote FAIR principles and to improve the value and knowledge from data innovation, HIFIS – a Helmholtz IT platform, provides a wide variety of services. This talk focuses on the lessons learned and the impact of integrating a variety of RSE offers, including educational resources and consulting on the research community in Helmholtz. We discuss the structure of the HIFIS consulting service and the resources needed to provide a good and fruitful environment for improving our clients’ software projects.
Prevalence of vertebral artery origin stenosis and occlusion in outpatient extracranial ultrasonography
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background and purpose—Most data on the prevalence of vertebral artery origin (VAo) disease is derived from hospital-based studies of patients with posterior circulation strokes and TIA. The prevalence of VAo disease in patients without posterior circulation symptoms or asymptomatic patients is poorly characterized. Our objective was to examine the prevalence of VAo stenosis and occlusion in consecutive patients, presenting for extracranial ultrasonography to an outpatient laboratory. Methods—We retrospectively identified 2490 consecutive extracranial duplex studies performed in an ambulatory neurovascular ultrasound laboratory. All studies were reviewed for the presence of >50% VAo stenosis, defined as a PSV > 114 cm/s, and VA occlusion. We also reviewed the prevalence of >50% carotid stenosis, defined as a PSV > 120 cm/s, in the same population, to draw comparisons with VAo stenosis prevalence. Results—We identified right VAo stenosis in 52/1955 (2.7%) and occlusion in 74/1955 (3.9%) and leftsided VAo stenosis in 45/1973 (2.5%) and occlusion in 64/1973 (3.6%). The prevalence of having any (either right or left) VAo stenosis or occlusion was 8.2% and 1.4% had bilateral VAo stenosis or occlusion. Right carotid stenosis and occlusion was found in 236/2399 (9.8%) and 53/2399 (2.2%) and left carotid stenosis and occlusion in 236/2397 (9.8%) and 45/2397 (1.9%), respectively. Any carotid disease, either right or left, was present in 18.9% and 4.7% had bilateral carotid disease. Conclusion—Although less prevalent than cervical carotid disease, we found
Map #481, Site 5MT10647, Major Cultural Units
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Major Cultural Units
Anticipatory prescribing in community end-of-life care in the UK and Ireland during the COVID-19 pandemic: online survey
Creators: name: Antunes, Bárbara
name: Bowers, Ben
name: Winterburn, Isaac
name: Kelly, Michael P
name: Brodrick, Robert
name: Pollock, Kristian
name: Majumder, Megha
name: Spathis, Anna
name: Lawrie, Iain
name: George, Rob
name: Ryan, Richella
name: Barclay, Stephen
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
2474
end of life care
drug administration
home care
terminal care
supportive care
nursing home care

description: Funder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272
description: Background: Anticipatory prescribing (AP) of injectable medications in advance of clinical need is established practice in community end-of-life care. Changes to prescribing guidelines and practice have been reported during the COVID-19 pandemic. Aims and objectives: To investigate UK and Ireland clinicians’ experiences concerning changes in AP during the COVID-19 pandemic and their recommendations for change. Methods: Online survey of participants at previous AP national workshops, members of the Association for Palliative Medicine of Great Britain and Ireland and other professional organisations, with snowball sampling. Results: Two hundred and sixty-one replies were received between 9 and 19 April 2020 from clinicians in community, hospice and hospital settings across all areas of the UK and Ireland. Changes to AP local guidance and practice were reported: route of administration (47%), drugs prescribed (38%), total quantities prescribed (35%), doses and ranges (29%). Concerns over shortages of nurses and doctors to administer subcutaneous injections led 37% to consider drug administration by family or social caregivers, often by buccal, sublingual and transdermal routes. Clinical contact and patient assessment were more often remote via telephone or video (63%). Recommendations for regulatory changes to permit drug repurposing and easier community access were made. Conclusions: The challenges of the COVID-19 pandemic for UK community palliative care has stimulated rapid innovation in AP. The extent to which these are implemented and their clinical efficacy need further examination.
ESTADO DE COISAS INCONSTITUCIONAL: UMA ANÁLISE DE SUA APLICAÇÃO NA DEFESA DOS DIREITOS COLETIVOS DOS SERVIDORES PÚBLICOS DA EDUCAÇÃO MINEIRA EM VIRTUDE DA LEI COMPLEMENTAR Nº 100/2007
Creators: name: HERINGER, HELIMARA
name: LEHFELD, LUCAS
Publisher: name: figshare
Year: 2021
Subjects: subject: 180108 Constitutional Law
subject: FOS: Law
subject: 180103 Administrative Law
subject: 180102 Access to Justice

description: Objetivo : o objetivo principal deste artigo é analisar a possibilidade de aplicação da tese do Estado de Coisas Inconstitucional (ICE), adotada pelo Tribunal Constitucional da Colômbia, ao caso de inconstitucionalidade da Lei Complementar nº 100/2007, de Minas Gerais, Brasil, que contratou milhares de trabalhadores temporários da educação de forma precária, sem respeitar os critérios exigidos pela Constituição Federal, com grave e generalizada violação dos direitos dos agentes direta e indiretamente envolvidos neste inconstitucional “estado de coisas” .Metodologia : A pesquisa adota o enfoque dedutivo, realizada com base na revisão bibliográfica e análise dos juízes T-068/10 e SU-559/97, da Corte Colombiana, e ADIs nºs 4.876 e nº 347, do STF.Resultados : O artigo demonstra que o caso da efetivação do trabalhador temporário da educação em Minas Gerais, de forma precária, e todas as consequências decorrentes da edição e declaração de inconstitucionalidade da chamada “Lei 100”, está inserido na o contexto de um “estado de coisas” inconstitucional que afeta tanto os direitos dos feitos precariamente quanto dos que foram licitados e tiveram suas vagas preenchidas de forma irregular.Contribuições : No contexto da concretização dos Direitos Coletivos, apresentar a tese do Estado Inconstitucional de Coisas como importante instrumento jurídico capaz de viabilizar direitos e promover a elaboração, execução e fiscalização de políticas públicas capazes de proteger os atingidos por o estado de coisas inconstitucional, como no caso da “Lei 100”.
Acute intermittent hypoxia : a potential therapeutic to improve cardiac function following experimental spinal cord injury
Creators: name: Mehdi, Ahmadian
Publisher: name: University of British Columbia
Year: 2023

description: Purpose: High-thoracic spinal cord injury (SCI) markedly impairs cardiac function. The purpose of this dissertation was to explore whether acute intermittent hypoxia (AIH), one of the most promising therapies in the field of SCI, has the potential to restore cardiac function in a rodent model of high-thoracic SCI. Prior to doing so, we first tested and validated multiple single-beat metrics of cardiac contractility that would allow us to track changes in cardiac inotropic function prior to, immediately after, and following the intervention of interest (i.e., AIH) in the present dissertation. Methods: Chapter 2: In a cross-species (i.e., rats, pigs, dogs) study consisting of eight experiments, we comprehensively tested whether the majority of previously reported/tested single-beat surrogates of cardiac contractility, together with two new proposed metrics, meet the assumptions required to be considered valid metrics for gauging cardiac contractile function in small and large animal models. Chapter 3: Through four experiments conducted in rodents, we tested whether 1) high-thoracic SCI reduces sympathetic nerve activity (SNA) and cardiac function in an animal model, 2) such reduced SNA post-injury contributes to cardiac functional decline in these animals, 3) AIH can mitigate sympathetic hypoactivity post-injury, and 4) AIH-induced sympathetic plasticity can be translated to end-organ function and improve cardiac function post-injury in these rodents. Results and conclusions: Findings from experiments in Chapter 2 confirmed that several, but not all, single-beat metrics of contractility can be used to measure cardiac contractile function in both small and large animal models. Findings from experiments in Chapter 3 demonstrated that high-thoracic SCI impairs cardiac function due to sympathetic hypoactivity that can be reversed with a single session of AIH when animals are treated at two weeks post-injury. These findings advance our understanding regarding the application of AIH in the field and set the stage for examining the potential cardiovascular benefit of therapeutic AIH in future clinical trials with a focus on improving cardiovascular function in individuals with SCI.
Subjective score
Creators: name: Minoura, Mai
Publisher: name: figshare
Year: 2021
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: The data set in the paper "Many a True Word is Spoken in Gesture; Bodily Self-Consciousness Arisen from Imitation of the Other’s Movement"
Map #35, Site 5MT10709, Midden 105, Nonstructure 110, and Arbitrary Unit 108, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: 5MT10709
valueUri: https://core.tdar.org/browse/site-name/118022/5mt10709
subject: Portulaca Point
valueUri: https://core.tdar.org/browse/site-name/118021/portulaca-point

description: Site 5MT10709, Midden 105, Nonstructure 110, and Arbitrary Unit 108, Stratigraphic Profile
Care-seeking during fatal childhood illness in rural South Africa: a qualitative study
Creators: name: Price, Jessica
name: Willcox, Merlin
name: Dlamini, Vuyiswa
name: Khosa, Audrey
name: Khanyile, Phindile
name: Seeley, Janet
name: Harnden, Anthony
name: Kahn, Kathleen
name: Hinton, Lisa
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Paediatrics
1506
1719
paediatrics
community child health
primary care
public health
qualitative research

description: Objectives: This study aimed to better understand reasons why children in South Africa die at home, including caregivers’ care-seeking experiences, decision-making, choice of treatment provider and barriers to accessing care during a child’s final illness. Design: This qualitative study included semi-structured in-depth interviews and focus group discussions with caregivers of children who died below the age of 5 years. Data were thematically analysed, and key findings compared with the Pathways to Survival Framework—a model frequently used in the study of child mortality. An adapted model was developed. Setting: Two rural health and demographic surveillance system (HDSS) sites in South Africa—the Agincourt HDSS and the Africa Health Research Institute. Participants: Thirty-eight caregivers of deceased children (29 participated in in-depth interviews and 9 were participants in two focus group discussions). Caregivers were purposively sampled to ensure maximum variation across place of death, child age at death, household socioeconomic status, maternal migration status and maternal HIV status. Findings: Although caregivers faced barriers in providing care to children (including insufficient knowledge and poor transport), almost all did seek care from the formal health system. Negative experiences in health facilities did not deter care-seeking, but most respondents still received poor quality care and were not given adequate safety-netting advice. Traditional healers were only consulted as a last resort when other approaches had failed. Conclusion: Barriers to accessing healthcare disrupt the workings of previously accepted care-seeking models. The adapted model presented in this paper more realistically reflects care-seeking experiences and decision-making during severe childhood illness in rural South Africa and helps explain both the persistence of home deaths despite seeking healthcare, and the impact of a child’s death on care-seeking in future childhood illness. This model can be used as the basis for developing interventions to reduce under-5 mortality.
PARTHENOS D6.6 PARTHENOS Cloud Infrastructure (final)
Creators: name: Pagano, Pasquale
name: Assante, Massimiliano
name: Frosini, Luca
name: Manghi, Paolo
name: Bardi, Alessia
name: Sinibaldi, Fabio
name: Cirillo, Roberto
name: Panichi, Giancarlo
Publisher: name: Zenodo
Year: 2019

description: “D6.6 PARTHENOS cloud infrastructure” is the revised and final version of “D6.1 PARTHENOS cloud infrastructure”. This deliverable reports the PARTHENOS e-infrastructure architecture: the hardware and the services. Hardware is organized as a dynamic cloud of virtual machines, supporting computation and storage, while the services are organized into e-infrastructure middleware, storage, and end user services.

All PARTHENOS deliverables are available at: http://www.parthenos-project.eu/resources/projects-deliverables
Rana fusca Rös.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Ranidae
Rana
Rana fusca

description: Rana fusca (platyrh.) Rös.
Oberweiler. Schweighof. Dornachschloss v. H. H. Knecht u. F M.
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 670, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
Creators: name: Baig, Sonia
name: Shabeer, Muhammad
name: Parvaresh Rizi, Ehsan
name: Agarwal, Madhur
name: Lee, Michelle H
name: Ooi, Delicia Shu Qin
name: Chia, Chelsea
name: Aung, Nweni
name: Ng, Geelyn
name: Teo, Yvonne
name: Chhay, Vanna
name: Magkos, Faidon
name: Vidal-Puig, Antonio
name: Seet, Raymond C S
name: Toh, Sue-Anne
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Genetics/Genomes/Proteomics/Metabolomics
1506
1879
family history of type 2 diabetes
oxidative stress
inflammation
myotubes
adipocytes
mononuclear cells

description: Introduction and objective: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study factors of susceptibility towards development of T2DM, which are poorly understood. Emerging key players in T2DM pathophysiology such as adverse oxidative stress and inflammatory responses could be among possible mechanisms that predispose FDRTs to develop T2DM. Here, we aimed to examine the role of oxidative stress and inflammatory responses as mediators of this excess risk by studying dynamic postprandial responses in FDRTs. Research design and methods: In this open-label case-control study, we recruited normoglycemic men with (n=9) or without (n=9) a family history of T2DM. We assessed plasma glucose, insulin, lipid profile, cytokines and F2-isoprostanes, expression levels of oxidative and inflammatory genes/proteins in circulating mononuclear cells (MNC), myotubes and adipocytes at baseline (fasting state), and after consumption of a carbohydrate-rich liquid meal or insulin stimulation. Results: Postprandial glucose and insulin responses were not different between groups. Expression of oxidant transcription factor NRF2 protein (p<0.05 for myotubes) and gene (pgroup=0.002, ptime×group=0.016), along with its target genes TXNRD1 (pgroup=0.004, ptime×group=0.007), GPX3 (pgroup=0.011, ptime×group=0.019) and SOD-1 (pgroup=0.046 and ptime×group=0.191) was upregulated in FDRT-derived MNC after meal ingestion or insulin stimulation. Synergistically, expression of target genes of inflammatory transcription factor nuclear factor kappa B such as tumor necrosis factor alpha (pgroup=0.001, ptime×group=0.007) was greater in FDRT-derived MNC than in non-FDRT-derived MNC after meal ingestion or insulin stimulation. Conclusions: Our findings shed light on how heredity of T2DM confers increased susceptibility to oxidative stress and inflammation. This could provide early insights into the underlying mechanisms and future risk of FDRTs for developing T2DM and its associated complications.
Cardioembolic stroke secondary to Lambl's excrescence on the aortic valve: a case report
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: A 59-year-old right-handed man presented to the emergency room with difficulty in understanding simple commands. There was no historical evidence of any such focal neurological symptoms or complaints. He received intravenous tissue plasminogen activator (IVtPA) and showed significant improvement, so he was transferred to our institution for further management. The patient had a history of schizophrenia and Parkinsonian symptoms secondary to chronic use of antipsychotics. He was on haloperidol and cogentin daily. He denied any use of tobacco, alcohol, or recreational drugs. On physical examination, the patient was afebrile with a blood pressure of 148/92 and a regular heart rate of 76. On neurological examination, he was found to be awake and alert. He had profound difficulty with naming, repetition, reading, and following simple commands. Cranial nerve examination was unremarkable. Motor examination revealed no focal weakness. Sensory, coordination, and motor examination were unremarkable. Laboratory workup revealed normal complete blood count, basic metabolic panel, and liver function tests. Magnetic resonance imaging (MRI) of the brain showed a moderate-sized region of acute infarction in the left middle cerebral artery (MCA) territory involving a portion of the insula and superior aspect of the temporal lobe. Magnetic resonance angiographic (MRA) studies revealed evidence of thrombosis in the left M2 division of the MCA. A transthoracic echocardiogram (TTE) revealed an ejection fraction of 70% and no evidence of thrombus or patent foramen ovale. Further workup included a transesophageal echocardiogram (TEE) which showed a linear, 1.1 cm mobile echodensity on the ventricular surface of the aortic valve leaflets, a finding that is consistent with Lambl's excrescence (LE) [Figures 1(A) and (b)]. The patient refused anticoagulation with Coumadin and was therefore started on aspirin and Lipitor. Cardiothoracic surgery recommended outpatient followup and evaluation for surgical removal of the Lambl's excrescence. The patient was discharged to home in a stable condition. Followup hypercoagulable workup was unremarkable.
Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARD PCI )
Creators: name: Norekvål, Tone M
name: Allore, Heather G
name: Bendz, Bjørn
name: Bjorvatn, Cathrine
name: Borregaard, Britt
name: Brørs, Gunhild
name: Deaton, Christi
name: Fålun, Nina
name: Hadjistavropoulos, Heather
name: Hansen, Tina Birgitte
name: Igland, Stig
name: Larsen, Alf Inge
name: Palm, Pernille
name: Pettersen, Trond Røed
name: Rasmussen, Trine Bernholdt
name: Schjøtt, Jan
name: Søgaard, Rikke
name: Valaker, Irene
name: Zwisler, Ann Dorthe
name: Rotevatn, Svein
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Cardiovascular medicine
1506
1683
continuity of care
adherence to treatment
health literacy
healthcare utilisation
percutaneous coronary intervention
rehabilitation

description: Introduction: Percutaneous coronary intervention (PCI) aims to provide instant relief of symptoms, and improve functional capacity and prognosis in patients with coronary artery disease. Although patients may experience a quick recovery, continuity of care from hospital to home can be challenging. Within a short time span, patients must adjust their lifestyle, incorporate medications and acquire new support. Thus, CONCARDPCI will identify bottlenecks in the patient journey from a patient perspective to lay the groundwork for integrated, coherent pathways with innovative modes of healthcare delivery. The main objective of the CONCARDPCI is to investigate (1) continuity of care, (2) health literacy and self-management, (3) adherence to treatment, and (4) healthcare utilisation and costs, and to determine associations with future short and long-term health outcomes in patients after PCI. Methods and analysis: This prospective multicentre cohort study organised in four thematic projects plans to include 3000 patients. All patients undergoing PCI at seven large PCI centres based in two Nordic countries are prospectively screened for eligibility and included in a cohort with a 1-year follow-up period including data collection of patient-reported outcomes (PRO) and a further 10-year follow-up for adverse events. In addition to PROs, data are collected from patient medical records and national compulsory registries. Ethics and dissemination: Approval has been granted by the Norwegian Regional Committee for Ethics in Medical Research in Western Norway (REK 2015/57), and the Data Protection Agency in the Zealand region (REG-145-2017). Findings will be disseminated widely through peer-reviewed publications and to patients through patient organisations. Trial registration number: NCT03810612.
The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial
Creators: name: Fowler, Cedar
name: Wu, Un-In
name: Shaffer, Robyn
name: Smith, Caroline
name: Barnhart, Lisa
name: Bryant, Clare
name: Olivier, Kenneth
name: Holland, Steven M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Respiratory infection
1506
2229
airway epithelium
atypical mycobacterial infection
respiratory infection
rare lung diseases
opportunist lung infections
innate immunity

description: Rationale: Pulmonary non-tuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Abnormal mucociliary clearance and abnormal nasal nitric oxide (nNO) have been associated with PNTM disease in other patient cohorts. Mucociliary clearance can be affected by NO-cyclic guanosine monophosphate signalling and, therefore, modulation of the pathway may be possible with phosphodiesterase inhibitors such as sildenafil as a novel therapeutic approach. Objective: To define ex vivo characteristics of PNTM disease affected by sildenafil. Methods: Subjects with PNTM infections were recruited into an open-label dose-escalation trial of sildenafil. Laboratory measurements and mucociliary measurements—ciliary beat frequency, nNO and 24-hour sputum production—were collected throughout the study period. Patients received sildenafil daily during the study period, with escalation from 20 to 40 mg three times per day. Measurements and main results: Increased ciliary beat frequency occurred after a single dose of 40 mg sildenafil and after extended dosing of 40 mg sildenafil. The increase ciliary beat frequency was not seen with 20 mg sildenafil dosing. There were no changes in sputum production, nNO production, Quality of Life-Bronchiectasis-NTM module (QOL-B-NTM) questionnaire or the St George’s Respiratory Questionnaire during the study period. Conclusion: Sildenafil, 40 mg, increased ciliary beat frequency acutely as well as with extended administration.
Session 1 live captioning for Roman2020 conference
Creators: name: Mutchler, Max
Publisher: name: Zenodo
Year: 2021
Subjects: Conference welcome and overview of Roman Space Telescope mission and science

description: Live captioning for session 1 was provided by CaptionMax. Some formatting and light editing was included by the Local Organizing Committee for added clarity, but there was no attempt to correct all live captioning errors.
AMS Analysis of Charcoal Samples From Semino Mountains, South Granite Mountain Fault System, Central Wyoming
Creators: name: Cummings, Linda Scott
name: Jones, Travis
Year: 2021
Subjects: subject: Seminoe Mountains, Wyoming
valueUri: https://core.tdar.org/browse/geographic-keyword/85544/seminoe-mountains-wyoming
subject: SOUTH GRANITE MOUNTAIN FAULT SYSTEM
valueUri: https://core.tdar.org/browse/site-name/118952/south-granite-mountain-fault-system
subject: Charcoal and Botanical Identification
valueUri: https://core.tdar.org/browse/material-type/3343/charcoal-and-botanical-identification
subject: Bulk Sediment
valueUri: https://core.tdar.org/browse/material-type/3010/bulk-sediment
subject: Dating Sample
valueUri: https://core.tdar.org/browse/material-type/3/dating-sample
subject: Charcoal
valueUri: https://core.tdar.org/browse/material-type/20/charcoal
subject: AMS
valueUri: https://core.tdar.org/browse/material-type/3338/ams

description: Eight bulk sediment samples were submitted for charcoal identification of radiocarbon datable materials and AMS radiocarbon dating from the south granite mountain fault system, Seminoe Mountains, central Wyoming.
Walk score and risk of stroke and stroke subtypes among town residents
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background—Regular physical activity, including light-to-moderate activity, such as walking, has wellestablished benefits for reducing the risk of ischemic stroke. It remains unknown, however, whether the characteristics of cities themselves can influence the risk of stroke by promoting such activity. Objectives—We tested the hypothesis that how walkable a city will be associated with the risk of ischemic stroke in persons residing in that city. Methods—We calculated the age-adjusted annual incidence rates of ischemic stroke among residents in each of the 63 cities in Minnesota for which Walk Scores were available using 2011 Minnesota Hospital Association (MHA) data. Walk Score®, an online service, uses an exclusive algorithm to compute a walkability score between 0 and 100 for any location within the United States. The score is calculated based on the distance to amenities in nine categories (grocery, restaurants, shopping, coffee, banks, parks, schools, books, and entertainment) weighed according to their importance. Results—There are 2,910,435 persons residing in the 63 Minnesota cities in our data (average population per town is 46,197). The average Walk Score of the 63 towns in Minnesota was 34, ranging from 14 to 69. The average median age of residents was similar in tertiles of towns based on Walk Score as follows: ≤25 (n=9) 36 years; 26–50 (n=46) 37 years; and 51–100 (n=8) 35 years. The age-adjusted incidence of ischemic stroke was similar in tertiles of towns based on Walk Score as follows: ≤25 (n=9) 341 per 100,000; 26–50 (n=46) 308 per 100,000; and 51–100 (n=8) 330 per 100,000 residents. The correlation between age-adjusted ischemic stroke incidence and Walk Score was low (R 2=0.09) within Minnesota. Conclusions—The ready availability of indices such as Walk Score make them attractive options for ischemic stroke risk correlation. Despite the lack of relationship in our study, further studies are required to measure the magnitude and health benefits of light-to-moderate activities performed within a town.
A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties
Creators: name: Greenfield, Katie
name: Holley, Simone
name: Schoth, Daniel Eric
name: Bayliss, Julie
name: Anderson, Anna-Karenia
name: Jassal, Satbir
name: Rajapakse, Dilini
name: Fraser, Lorna Katharine
name: Mott, Christine
name: Johnson, Margaret
name: Wong, Ian
name: Howard, Richard
name: Harrop, Emily
name: Liossi, Christina
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Oncology
1506
1717
pain management
neurological pain
cancer pain

description: Introduction: Breakthrough pain is common in children and adults with cancer and other conditions, including those approaching end-of-life, although it is often poorly managed, possibly partly due to a lack of validated assessment tools. This review aims to (1) identify all available instruments measuring breakthrough pain in infants, children, adolescents or adults and (2) critically appraise, compare and summarise the quality of the psychometric properties of the identified instruments using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. Methods and analysis: Two searches will be carried out between October 2019 and January 2020, one for each aim of the review. The Cochrane Library, International Prospective Register of Systematic Reviews, Embase, Cumulative Index of Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online (MEDLINE), PsycINFO, Web of Science Core Collection, Google Scholar, the ProQuest Dissertations & Theses Database, Evidence Search and OpenGrey databases will be searched from database inception until the date the search is conducted. Reference lists of eligible articles will be screened and authors in the field contacted. For search 1, articles will be screened by two reviewers by abstract, and full-text where necessary, to identify if a breakthrough pain assessment was used. Search 2 will then be conducted to identify studies evaluating measurement properties of these assessments. Two reviewers will screen articles from search 2 by title and abstract. All potentially relevant studies will be screened by full text by both reviewers. For search 2, data will be extracted in parallel with the quality assessment process, as recommended by COSMIN. Two reviewers will assess methodological quality using the COSMIN Risk of Bias checklist and the COSMIN updated criteria for good measurement properties. Findings will be summarised and, if possible, data will be pooled using meta-analysis. The quality of the evidence will be graded and summarised using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines. Ethics and dissemination: Results of this review will be submitted for publication in a peer review journal and presented at conferences. PROSPERO registration number: CRD42019155583.
T-Res Wave 1 survey questions
Creators: name: Sinead Smyth
Publisher: name: figshare
Year: 2021
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology

description: This PDF document includes the questions asked during the first wave of the T-Res survey regarding the experiences, wellbeing and needs of children with autism and their families during the COVI-19 pandemic.
Association between plant-based diets and blood pressure in the INTERMAP study
Creators: name: Aljuraiban, Ghadeer
name: Chan, Queenie
name: Gibson, Rachel
name: Stamler, Jeremiah
name: Daviglus, Martha L
name: Dyer, Alan R
name: Miura, Katsuyuki
name: Wu, Yangfeng
name: Ueshima, Hirotsugu
name: Zhao, Liancheng
name: Van Horn, Linda
name: Elliott, Paul
name: Oude Griep, Linda M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
blood pressure lowering
dietary patterns

description: Background: Plant-based diets are associated with a lower risk of cardiovascular diseases; however, little is known how the healthiness of the diet may be associated with blood pressure (BP). We aimed to modify three plant -based diet indices: overall plant-based diet index (PDI), healthy PDI (hPDI), and unhealthy PDI (uPDI) according to country-specific dietary guidelines to enable use across populations with diverse dietary patterns – and assessed their associations with BP. Design: We used cross-sectional data including 4,680 men and women ages 40–59y in Japan, China, the United Kingdom, and the United States from the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP). During four visits, eight BP measurements, and four 24-h dietary recalls were collected. Multivariable regression coefficients were estimated, pooled, weighted, and adjusted extensively for lifestyle/dietary confounders. Results: Modified PDI was not associated with BP. Consumption of hPDI higher by 1SD was inversely associated with systolic (-0.82 mm Hg;95% CI:-1.32,-0.49) and diastolic BP (-0.49 mm Hg; 95% CI:-0.91, -0.28). In contrast, consumption of an uPDI was directly associated with systolic (0.77 mm Hg;95% CI:0.30,1.20). Significant associations between hPDI with BP were attenuated with separate adjustment for vegetables and whole grains; associations between uPDI and BP were attenuated after adjustment for refined grains, sugar-sweetened beverages, and meat. Conclusion: An hPDI is associated with lower BP while a uPDI is adversely related to BP. Plant-based diets rich in vegetables and whole grains and limited in refined grains, sugar-sweetened beverages, and total meat may contribute to these associations. In addition to current guidelines, the nutritional quality of consumed plant foods is as important as limiting animal-based components. Trial registration number: The observational INTERMAP study was registered at www.clinicaltrials.gov as NCT00005271.
Qualitative study to explore radiologist and radiologic technologist perceptions of outcomes patients experience during imaging in the USA
Creators: name: Zigman Suchsland, Monica
name: Cruz, Maria Jessica
name: Hardy, Victoria
name: Jarvik, Jeffrey
name: McMillan, Gianna
name: Brittain, Anne
name: Thompson, Matthew
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Radiology and imaging
1506
1726
radiology & imaging
radiologist
radiologic technologist
patient preferences

description: Objective: We aimed to explore the patient-centred outcomes (PCOs) radiologists and radiologic technologists perceive to be important to patients undergoing imaging procedures. Design: We conducted a qualitative study of individual semi-structured interviews. Participants: We recruited multiple types of radiologists including general, musculoskeletal neuroradiology, body and breast imagers as well as X-ray, ultrasound, CT or MRI radiologic technologists from Washington and Idaho. Outcome: Thematic analysis was conducted to identify themes and subthemes related to PCOs of imaging procedures. Results: Ten radiologists and six radiology technologists participated. Four main domains of PCOs were identified: emotions, physical factors, knowledge and patient burden. In addition to these outcomes, we also identified patient and provider factors that can potentially moderate these outcomes. Conclusions: Radiologists and technologists perceived outcomes related to the effect of imaging procedures on patients’ emotions, physical well-being, knowledge and burden from financial and opportunity costs to be important to patients undergoing imaging procedures. There are opportunities for the radiology community to measure and use these PCOs in comparisons of imaging procedures and potentially identify areas where these outcomes can be leveraged to drive a more patient-centred approach to radiology.
A survey of preprocedural intubation practices for endovascular treatment of acute ischemic stroke
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background—In the absence of specific guidelines, there is considerable variance in preprocedural intubation practices for endovascular treatment of acute ischemic stroke. The purpose of this study is to understand and characterize the variance in preprocedural intubation practices and identify the reasons that influence the choice of preprocedural intubation practices among treating physicians. Methods—We selected 10 random cases from a prospective database of patients undergoing endovascular treatment for acute ischemic stroke and prepared a case summary providing pertinent demographic, clinical, and imaging data. Twenty clinicians independently reviewed the case summaries and responded to whether they would intubate any of the 10 patients and identified the reasons for their choices. Clinicians were also asked to identify their training background (neurology-, neurosurgery-, or radiology-trained endovascular specialist, vascular neurologist or neurointensivist). Reasons for intubation and agreement between clinicians for each case were ascertained. Results—The decision to intubate the patient was made in 63 of 200 total clinical scenarios. The major reasons identified by the physicians for preprocedural intubation were high National Institute of Health stroke scale scores on admission 26.9% (n = 17), labored breathing or desaturation 23.8% (n = 15), less than optimal respiratory status of patients combined with drowsiness or reduced level of consciousness 14.3% (n = 9), inability to follow command due to aphasia 12.7% (n = 8), seizures 1.6% ( n = 1), and no reason 20.6% (n = 13). Overall agreement between clinicians regarding decision of preprocedural intubation among the 10 case scenarios was 30.1% (standard error [SE] 2.3%). The agreement between neurosurgeons was 37.5% (SE = 31.6), interventional neurologist 19.8% (SE = 4.7), and vascular neurologist/neurointensivist 39.3% (SE = 5.9). Conclusion—The decision of preprocedural intubation varies widely among clinicians. Because of recent data that suggests that decision of preprocedural intubation may impact on patients' outcomes, better standardization of such practices is required
Cultural change fast and slow : a novel measure of the speed of cultural change
Creators: name: Kay, Nick
Publisher: name: University of British Columbia
Year: 2023

description: What cross-national patterns of variation in the speed of cultural change exist? And what explains this variation? Prior research on cultural change has tended to focus on describing and explaining changes along narrow dimensions of culture, while leaving these questions about broader patterns of cultural change unaddressed. Due to this dimension-focused approach, cultural psychology has yet to develop any adequate methods for measuring cross-national variation in the speed of cultural change. To address the gap in the literature, we repurpose statistical tools conventionally used to measure cross-national cultural distance and develop an index measuring country-level rates of cultural change over the last 20 years: the cultural change index. We present our approach to building this index and provide an analysis of its statistical properties and robustness. We perform exploratory analyses that examine the correlation between the cultural change index and a wide range of variables that prior research has identified as potentially having a causal impact on the speed of cultural change. We find correlations with the cultural change index across five classes of predictor variables— socioeconomic development, globalization, gender equality, cultural orientations, and ecological factors. To conclude, we discuss limitations of the present research and make recommendations for how future research on this topic can build upon our measurement techniques and analytical approaches.
Radiofrequency denervation for chronic back pain: a systematic review and meta-analysis
Creators: name: Chappell, Mary Elizabeth
name: Lakshman, Raj
name: Trotter, Patrick
name: Abrahams, Mark
name: Lee, Michael
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Rheumatology
1506
1732
back pain
rheumatology
neurology
pain management

description: Objectives: To assess the effectiveness of radiofrequency denervation (RD) of lumbosacral anatomical targets for the management of chronic back pain. Design: Systematic review and meta-analysis of randomised controlled trials (RCTs). Methods: A database search (Medline, Medline in Process, Embase, CINHAL and the Cochrane library) was conducted from January 2014 to April 2019 for placebo or no-treatment controlled trials of RD for the management of chronic back pain. Included trials were quality assessed using the Cochrane Risk-of-Bias Tool and the quality of outcomes assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Meta-analysis was conducted to calculate mean difference (MD) in post-treatment Pain Score. Results: Nineteen RCTs were included in the review. There appears to be short-term pain relief (1–3 months) provided by RD of the sacroiliac joint (five trials, MD −1.53, CI −2.62 to 0.45) and intervertebral discs (four trials, MD −0.98, CI −1.84 to 0.12), but the placebo effect is large and additional intervention effect size is small (<1 on an 11 point (0–10) Pain Scale). Longer-term effectiveness (>6 months) is uncertain. Conclusions: RD of selected lumbosacral targets appears to have a small, short-term, positive effect for the management of patients with chronic back pain. However, the quality of evidence for the majority of outcomes is low or very low quality and there is still a degree of uncertainty, particularly around the duration of effect.
Genetically Modified Crops’ Technology and its Awareness among Smallholder Farmers in Nigeria
Creators: name: Obi-Egbedi, Ogheneruemu
name: Oluwatayo, Isaac B.
name: Ogungbite, Omowunmi
name: Obi-Egbedi, Ogheneruemu
name: Oluwatayo, Isaac B.
name: Ogungbite, Omowunmi
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agribusiness
subject: Community/Rural/Urban Development
subject: GMOs
subject: smallholder farmers
subject: awareness for GM crops
subject: credible seed sources
subject: agricultural technology

description: Genetically Modified (GM) crops are crops modified through genetic engineering to improve their quality. Although safety concerns about genetically modified organisms (GMOs) are still being debated, the food security benefits have led to adoption by many counties. In Nigeria, where most farmers are uneducated and likely unaware of the agricultural technology, the government approved its first biotechnology crop for commercialization in 2018. Level of farmers’ awareness is crucial to acceptance of GM crops, although; this has not been fully explored in the literature. Therefore, this study aimed to assess farmers’ awareness for GM crops and the factors that determine their awareness in Oyo state, Nigeria, using primary data collected in 2018 with the aid of well-structured questionnaires from 242 smallholder farmers. Principal component analysis and Tobit regression model were used for data analysis. Results showed that farmers were aged 43 years with farm size of 3.57 ha, farming experience of 14 years and 11 years of education. Most farmers were male (71.90%), married (67.36%), not members of farmer groups (64.46%) and sourced their seeds from non-credible sources (85.12%). Most farmers (52.07%) had either not heard of or did not know of any benefits/costs of GM crops, hence; were not aware of GM crops. Factors that influenced awareness of GM crops were being a male farmer, years of education and source of seeds. The study concluded that increasing years of education and ensuring use of credible seed sources will increase awareness of the costs and benefits of GM crops among farmers.
description: DOI: 10.22630/PRS.2020.20.4.22