cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effect of polyterpenol thin film surfaces on bacterial viability and adhesion
Creators: name: Bazaka, Kateryna
name: Jacob, Mohan
name: Truong, Vi Khanh
name: Crawford, Russell
name: Ivanova, Elena
Publisher: name: Swinburne
Year: 2024

description: The nanometer scale surface topography of a solid substrate is known to influence the extent of bacterial attachment and their subsequent proliferation to form biofilms. As an extension of our previous work on the development of a novel organic polymer coating for the prevention of growth of medically significant bacteria on three-dimensional solid surfaces, this study examines the effect of surface coating on the adhesion and proliferation tendencies of Staphylococcus aureus and compares to those previously investigated tendencies of Pseudomonas aeruginosa on similar coatings. Radio frequency plasma enhanced chemical vapor deposition was used to coat the surface of the substrate with thin film of terpinen-4-ol, a constituent of tea-tree oil known to inhibit the growth of a broad range of bacteria. The presence of the coating decreased the substrate surface roughness from approximately 2.1 nm to 0.4 nm. Similar to P. aeruginosa, S. aureus presented notably different patterns of attachment in response to the presence of the surface film, where the amount of attachment, extracellular polymeric substance production, and cell proliferation on the coated surface was found to be greatly reduced compared to that obtained on the unmodified surface. This work suggests that the antimicrobial and antifouling coating used in this study could be effectively integrated into medical and other clinically relevant devices to prevent bacterial growth and to minimize bacteria-associated adverse host responses.
Modifications to surface chemistry and nanotopography of poly(ethylene terephthalate) by marine bacteria
Creators: name: Webb, Hayden
name: Crawford, Russell
name: Ivanova, Elena
Publisher: name: Swinburne
Year: 2024

description: The surface chemistry and nanotopography of poly(ethylene terephthalate) (PET) was successfully modified by marine bacteria, indicating the initial stages of biodegradation. PET surfaces became rougher relative to the control surfaces in the presence of bacterial communities regardless of whether they were primarily phototrophic or heterotrophic. Only surfaces exposed to primarily heterotrophic bacteria, however, changed significantly in surface chemistry; these samples showed a decrease in oxygen groups across the surface. The results seem to indicate two different mechanisms of PET degradation depending on whether the bacterial community is primarily phototrophic or heterotrophic.
Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells
Creators: name: Chunlei Jin
name: Taichun Qin
name: Barton, Michelle Craig
name: Jelinek, Jaroslav
name: Issa, Jean-Pierre J
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Oxidation of 5-methylcytosine by TET family proteins can induce DNA replication-dependent (passive) DNA demethylation and base excision repair (BER)-based (active) DNA demethylation. The balance of active vs. passive TET-induced demethylation remains incompletely determined. In the context of large scale DNA demethylation, active demethylation may require massive induction of the DNA repair machinery and thus compromise genome stability. To study this issue, we constructed a tetracycline-controlled TET-induced global DNA demethylation system in HEK293T cells. Upon TET overexpression, we observed induction of DNA damage and activation of a DNA damage response; however, BER genes are not upregulated to promote DNA repair. Depletion of TDG (thymine DNA glycosylase) or APEX1 (apurinic/apyrimidinic endonuclease 1), two key BER enzymes, enhances rather than impairs global DNA demethylation, which can be explained by stimulated proliferation. By contrast, growth arrest dramatically blocks TET-induced global DNA demethylation. Thus, in the context of TET-induction in HEK293T cells, the DNA replication-dependent passive mechanism functions as the predominant pathway for global DNA demethylation. In the same context, BER-based active demethylation is markedly restricted by limited BER upregulation, thus potentially preventing a disastrous DNA damage response to extensive active DNA demethylation.
Oxynoemacheilus persa
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Nemacheilidae
Oxynoemacheilus
Oxynoemacheilus persa

description: 43. Oxynoemacheilus persa (Heckel, 1849)
Common name. Persian stone loach
Taxonomy. Original description: Cobitis persa Heckel, 1847: 266 [Springs at Persepolis, Fars Province, Iran; holotype (unique): NMW 48567].
Revisions. None.
Illustrations. Sayyadzadeh et al. (2018b: 45, fig. 11).
Distribution in Iran. —Distribution in River Basin: Kor River, Persis, Lake Maharlu.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Loch mahi-e Parsi.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 21, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment
Creators: name: Bhawna Jain Garg
name: Garg, Neeraj K.
name: Sarwar Beg
name: Singh, Bhupinder
name: Katare, Om Prakash
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: The present investigation aimed for the development and characterization of ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery and effective treatment against vitiligo. The ethosomes were prepared by central composite design (CCD) and characterized for various quality attributes like vesicle shape, size, zeta potential, lamellarity, drug entrapment and drug leaching. The optimized ethosomes were subsequently incorporated int Carbopol® 934 gel and characterized for drug content, rheological behavior, texture profile, in vitro release, ex vivo skin permeation and retention, skin photosensitization and histopathological examination. Ethosomes were found to be spherical and multilamellar in structures having nanometric size range with narrow size distribution, and high encapsulation efficiency. Ethosomal formulations showed significant skin permeation and accumulation in the epidermal and dermal layers. The fluorescence microscopy study using 123 Rhodamine exhibited enhanced permeation of the drug-loaded ethosomes in the deeper layers of skin. Also, the developed formulation showed insignificant phototoxicity and erythema vis-à-vis the conventional cream. The results were cross-validated using histopathological examination of skin segments. In a nutshell, the ethosomes-based hydrogel formulation was found to be a promising drug delivery system demonstrating enhanced percutaneous penetration of methoxsalen with reduced phototoxicity and erythema, thus leading to improved patient compliance for the treatment against vitiligo.
Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway
Creators: name: Y. Chen
name: W. Qing
name: M. Sun
name: L. Lv
name: D. Guo
name: Y. Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Melatonin, an indolamine synthesized in the pineal gland, shows a wide range of physiological functions, and is under clinical investigation for expanded applications. Melatonin has demonstrated efficient protective effects against various types of oxidative damage in the liver system. This study investigates the protective effects of melatonin pretreatment on glycochenodeoxycholic acid (GCDCA)-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Melatonin markedly decreased mitochondrial ROS (mROS) production in L02 cells treated with 100 μM GCDCA, and inhibited GCDCA-stimulated cytotoxicity. Notably, melatonin exerted its hepatoprotective effects by upregulating sirtuin 3 (SIRT3) activity and its expression level, thus regulating superoxide dismutase 2 (SOD2) acetylation and inhibiting the production of mROS induced by GCDCA. Moreover, siRNA targeting SIRT3 blocked the melatonin-mediated elevation in mitochondrial function by inhibiting SIRT3/SOD2 signaling. Importantly, melatonin-activated SIRT3 activity was completely abolished by AMP-activated, alpha 1 catalytic subunit (AMPK) siRNA transfection. Similar results were obtained in rat with bile duct ligation or BDL. In summary, our findings indicate that melatonin is a novel hepatoprotective small molecule that functions by elevating SIRT3, stimulating SOD2 activity, and suppressing mitochondrial oxidative stress at least through AMPK, and that SIRT3 may be of therapeutic value in liver cell protection for GCDCA-induced hepatotoxicity.
title: Jogo de tabuleiro terapêutico com enfoque na tuberculose
Creators: name: Pinheiro, Catarina
name: Romeiro, Joana
Publisher: name: Universidade Católica Portuguesa
publisherIdentifier: https://ror.org/03b9snr86
publisherIdentifierScheme: ROR
Year: 2024

description: A criação de um jogo de tabuleiro terapêutico permite associar o brincar terapêutico à capacitação sobre a tuberculose e os cuidados de etiqueta respiratória. Constitui-se como uma intervenção de enfermagem, com o principal propósito de promover a aprendizagem, a interação e o brincar, em meio hospitalar ou no domicílio. No final do jogo, perante uma vitória, deverá ser fornecido um desenho para colorir, o que fomenta a motricidade bem como o desenvolvimento intelectual.
description: The creation of a therapeutic board game allows therapeutic play to be associated with training on tuberculosis disease and respiratory etiquette. It is a nursing intervention with the main purpose of promoting learning, interaction, and play, in a hospital setting or at home. At the end of the game, if there is a victory, you'll be given a drawing to color in, which encourages motor skills as well as intellectual development.
Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment
Creators: name: Bhawna Jain Garg
name: Garg, Neeraj K.
name: Sarwar Beg
name: Singh, Bhupinder
name: Katare, Om Prakash
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: The present investigation aimed for the development and characterization of ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery and effective treatment against vitiligo. The ethosomes were prepared by central composite design (CCD) and characterized for various quality attributes like vesicle shape, size, zeta potential, lamellarity, drug entrapment and drug leaching. The optimized ethosomes were subsequently incorporated int Carbopol® 934 gel and characterized for drug content, rheological behavior, texture profile, in vitro release, ex vivo skin permeation and retention, skin photosensitization and histopathological examination. Ethosomes were found to be spherical and multilamellar in structures having nanometric size range with narrow size distribution, and high encapsulation efficiency. Ethosomal formulations showed significant skin permeation and accumulation in the epidermal and dermal layers. The fluorescence microscopy study using 123 Rhodamine exhibited enhanced permeation of the drug-loaded ethosomes in the deeper layers of skin. Also, the developed formulation showed insignificant phototoxicity and erythema vis-à-vis the conventional cream. The results were cross-validated using histopathological examination of skin segments. In a nutshell, the ethosomes-based hydrogel formulation was found to be a promising drug delivery system demonstrating enhanced percutaneous penetration of methoxsalen with reduced phototoxicity and erythema, thus leading to improved patient compliance for the treatment against vitiligo.
THE USE OF SHADOWING EDUCATIONAL TECHNOLOGY IN THE DEVELOPMENT OF ORAL SPEECH IN TEACHING A FOREIGN LANGUAGE
Creators: name: Bolbekova, Ug'iloy
name: Abdurasulov, Firdavs
name: Saidaliyev, Shuhrat
Publisher: name: Zenodo
Year: 2024

description: This article describes the peculiarities of oral speech i.e. talkative and listening skills in teaching foreign languages and the use of shadowing educational technologies in the development of oral speech.
Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis
Creators: name: Takeuchi, Tsutomu
name: Yamanaka, Hisashi
name: Tanaka, Yoshiya
name: Sakurai, Takeo
name: Saito, Kazuyoshi
name: Ohtsubo, Hideo
name: Lee, Sang Joon
name: Nambu, Yoshihiro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives. To demonstrate the pharmacokinetic equivalence of CT-P13 and its innovator infliximab (IFX) in Japanese patients with rheumatoid arthritis (RA), and to compare the efficacy and safety of these drugs, administered for 54 weeks. Methods. In a randomized, double-blind, parallel-group, multicenter study, 3 mg/kg of CT-P13 or IFX, in combination with methotrexate (MTX) (6–16 mg/week), was administered for 54 weeks to Japanese active RA patients with an inadequate response to MTX, to demonstrate the pharmacokinetic equivalence, based on the area under the curve (AUCτ) (weeks 6–14) and Cmax (week 6) of these drugs, and to compare their efficacy and safety. Results. The CT-P13-to-IFX ratios (90% confidence intervals) of the geometric mean AUCτ and Cmax values in patients negative for antibodies to infliximab at week 14 were 111.62% (100.24–124.29%) and 104.09% (92.12–117.61%), respectively, demonstrating the pharmacokinetic equivalence of these drugs. In the full analysis set, CT-P13 and IFX showed comparable therapeutic effectiveness, as measured by the American College of Rheumatology, Disease Activity Score in 28 joints, the European League Against Rheumatism, and other efficacy criteria, at weeks 14 and 30. The incidence of adverse events was similar for these drugs. Conclusion. CT-P13 and IFX, administered at a dose of 3 mg/kg in combination with MTX to active RA patients, were pharmacokinetically equivalent and comparable in efficacy and safety.
Oxynoemacheilus tongiorgii
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Nemacheilidae
Oxynoemacheilus
Oxynoemacheilus tongiorgii

description: 44. Oxynoemacheilus tongiorgii (Nalbant & Bianco, 1998)
Common name. Tongiorgi stone loach
Taxonomy. Original description: Seminemacheilus tongiorgii Nalbant & Bianco, 1998: 113, figs. 11 A-D [Large water spring near Darab town, Kul River basin, Iran; holotype: IZA 801. Paratypes: ISBB uncat. (1)].
Revisions. None.
Illustrations. Nalbant & Bianco (1998: 113, fig. 11).
Distribution in Iran. —Distribution in River Basin: Kor River.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Loch mahi-e Kor.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: IZA, ZM-CBSU.
Conservation. —IUCN: DD.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 21, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
On the Use of Properties in Java Applications
Creators: name: Lumpe, Markus
name: Mahmud, Samiran
name: Vasa, Rajesh
Publisher: name: Swinburne
Year: 2024

description: When building software systems, developers have to weigh the benefits of using one specific solution approach against the risks and costs of using another one. This process is not random. Certain preferences, architectural styles, and solution domain pressures create systematic biases that we can measure in order to assess their impact on the system being built and the underlying development process itself. In this paper we explore, whether the getter and setter methods in Java give rise to a bias also. Getter and setter methods, called 'properties', are perceived commonplace and considered by some as a threat to data encapsulation. However, little empirical evidence exists that can reliably inform us about the real impact of the use of properties in Java. For this reason, we examined 102 open-source Java systems and discovered that properties are employed much more carefully than one might expect. Contrary to some folklore, developers use properties not just to gain access to an object's private state, but in a systematic and responsible manner and, in general, consistent with the domain requirements of the developed software system.
The accuracy of clinical prediction of prognosis for patients admitted with sepsis to internal medicine departments
Creators: name: Ghanem-Zoubi, Nesrin
name: Bitterman, Haim
name: Laor, Arie
name: Yurin, Vitaly
name: Vardi, Moshe
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Cancer
Biological Sciences
Earth and Environmental Sciences
Biotechnology
Medicine

description: Introduction Prognosis estimation offered by physicians for patients inflicted by sepsis on their admission to Internal Medicine (IM) departments is considered a challenge. Early prognosis estimation is critical and determines the intensity of treatment offered. The accuracy of prognosis estimation made by physicians has previously been investigated mainly among intensive care physicians and oncologists.Objective To ascertain the accuracy of prognosis prediction made by internists for septic patients on admission to IM departments.Methods Physicians were asked to estimate the prognosis of every patient identified to have sepsis on admission. Their intuitive assessment of prognosis was incorporated into the patients’ electronic medical record. Survival follow-up was recorded until death or for at least 2 years. Later we compared survival with physicians’ prognosis estimations.Results Prognosis estimation was recorded for 1,073 consecutive septic patients admitted throughout the years 2008–2009 to IM departments. The mean age of patients was 74.7 ± 16.1 years. A total of 42.4% were suspected to have pneumonia, and 65.4% died during a mean follow-up time of 661.1 ± 612.3 days. Almost half of the patients classified to have good prognosis survived compared to 14.9% and 4.9% of those with intermediate and bad prognosis estimation, respectively (P Conclusion Internists can discriminate well between septic patients with good, intermediate, and bad prognosis.Key MessagesMany patients suffering from sepsis are treated at general medical departments.Good estimation of the severity of disease upon admission is critical for decision-making regarding treatment.Internists including junior staff could discriminate well between patients with different degrees of disease severity of sepsis.
Minimal Role of Base Excision Repair in TET-Induced Global DNA Demethylation in HEK293T Cells
Creators: name: Chunlei Jin
name: Taichun Qin
name: Barton, Michelle Craig
name: Jelinek, Jaroslav
name: Issa, Jean-Pierre J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Meta Science
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Oxidation of 5-methylcytosine by TET family proteins can induce DNA replication-dependent (passive) DNA demethylation and base excision repair (BER)-based (active) DNA demethylation. The balance of active vs. passive TET-induced demethylation remains incompletely determined. In the context of large scale DNA demethylation, active demethylation may require massive induction of the DNA repair machinery and thus compromise genome stability. To study this issue, we constructed a tetracycline-controlled TET-induced global DNA demethylation system in HEK293T cells. Upon TET overexpression, we observed induction of DNA damage and activation of a DNA damage response; however, BER genes are not upregulated to promote DNA repair. Depletion of TDG (thymine DNA glycosylase) or APEX1 (apurinic/apyrimidinic endonuclease 1), two key BER enzymes, enhances rather than impairs global DNA demethylation, which can be explained by the stimulated proliferation. By contrast, growth arrest dramatically blocks TET-induced global DNA demethylation. Thus, in the context of TET-induction in HEK293T cells, the DNA replication-dependent passive mechanism functions as the predominant pathway for global DNA demethylation. In the same context, BER-based active demethylation is markedly restricted by limited BER upregulation, thus potentially preventing a disastrous DNA damage response to extensive active DNA demethylation.
An empirical study of the effects of conscientiousness in pair programming using the five-factor personality model
Creators: name: Salleh, Norsaremah
name: Mendes, Emilia
name: Grundy, John
name: Burch, Giles St. J
Publisher: name: Swinburne
Year: 2024

description: This paper describes a formal experiment carried out to investigate the effect of the Personality factor conscientiousness on the effectiveness of Pair Programming as a pedagogical tool in higher Education. This experiment took place at the University of Auckland, using as subjects undergraduate students attending an introductory programming course. Conscientiousness was chosen because it has been shown to be the most consistent predictor of academic achievement. Our findings showed that differences in conscientiousness level did not significantly affect the academic performance of students who pair programmed, which could have been due to the short duration of the tasks used throughout the experiment. However, results revealed that another Personality factor - Openness to experience - presented a significant correlation with paired students' academic performance.
FOSSR Fourth Online Seminar: The FOSSR Policy Learning Platform: A Tutorial
Creators: name: Cerulli, Giovanni
name: Brogi, Federico
name: De Fausti, Fabrizio
Publisher: name: Zenodo
Year: 2025
Subjects: Policy Learning Platform (PLP)
Algorithm Implementation
Optimal Policy Learning
Machine learning

description: The folder contains the presentations and abstracts of the FOSSR First Online Seminar dedicated to present a tutorial for the Policy Learning Platform (PLP) a FOSSR tool for learning optimal policies from data allowing for empirical welfare maximization.Implemented by the OPL set of algorithms, the PLP allows to find “treatment assignment rules” that maximize the overall welfare, defined as the sum of the policy effects estimated over all the policy beneficiaries.

The PLP allows to learn the optimal policy empirically, i.e. based on data and observations obtained from previous (same or similar) implemented policies. The PLP carries out empirical welfare maximization within three policy classes: (i) Threshold-based; (ii) Linear-combination; and (iii) Decision-tree. We present three implementation of the PLP, using three platforms, i.e. Stata, R and Python.

The seminar will be divided into three short persentations by Giovanni Cerulli (CNR-IRCrES), Federico Brogi (ISTAT) and Fabrizio De Fausti (ISTAT), followed by an open conversation with the discussants Marco Ventura (University of Rome ‘La Sapienza’) and Barbara Guardabascio (University of Perugia).

Welcome opening by Claudia Pennacchiotti (CNR-IRPPS).

 
description: Link to the Online Seminar video recording: https://l.cnr.it/fossr-fourth-online-seminar-video
Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis
Creators: name: Takeuchi, Tsutomu
name: Yamanaka, Hisashi
name: Tanaka, Yoshiya
name: Sakurai, Takeo
name: Saito, Kazuyoshi
name: Ohtsubo, Hideo
name: Lee, Sang Joon
name: Nambu, Yoshihiro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Medicine
subject: Engineering

description: Objectives. To demonstrate the pharmacokinetic equivalence of CT-P13 and its innovator infliximab (IFX) in Japanese patients with rheumatoid arthritis (RA), and to compare the efficacy and safety of these drugs, administered for 54 weeks.Methods. In a randomized, double-blind, parallel-group, multicenter study, 3 mg/kg of CT-P13 or IFX, in combination with methotrexate (MTX) (6–16 mg/week), was administered for 54 weeks to Japanese active RA patients with an inadequate response to MTX, to demonstrate the pharmacokinetic equivalence, based on the area under the curve (AUCτ) (weeks 6–14) and Cmax (week 6) of these drugs, and to compare their efficacy and safety.Results. The CT-P13-to-IFX ratios (90% confidence intervals) of the geometric mean AUCτ and Cmax values in patients negative for antibodies to infliximab at week 14 were 111.62% (100.24–124.29%) and 104.09% (92.12–117.61%), respectively, demonstrating the pharmacokinetic equivalence of these drugs. In the full analysis set, CT-P13 and IFX showed comparable therapeutic effectiveness, as measured by the American College of Rheumatology, Disease Activity Score in 28 joints, the European League Against Rheumatism, and other efficacy criteria, at weeks 14 and 30. The incidence of adverse events was similar for these drugs.Conclusion. CT-P13 and IFX, administered at a dose of 3 mg/kg in combination with MTX to active RA patients, were pharmacokinetically equivalent and comparable in efficacy and safety.
Application of amino acid ionic liquids for increasing the stability of DNA in long term storage
Creators: name: Khavani, Mohammad
name: Mehranfar, Aliyeh
name: Vahid, Hossein
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The structural stability of DNA is important because of its biological activity. DNAs due to their inherent chemical properties are not stable in an aqueous solution, therefore, a long period of storage of DNA at the ambient condition in bioscience is of importance. Ionic liquids (ILs) as interesting alternatives compared to organic solvents and water due to their considerable properties can be used as new agents to increase the stability of DNA for a long period of storage. In this article, molecular dynamics (MD) simulations and quantum chemistry calculations were applied to investigate the effects of amino acid ionic liquids ([BMIM][Ala], [BMIM][Gly], [BMIM][Val], [BMIM][Pro] and [BMIM][Leu]) on the dynamical behavior and the structural stability of calf thymus DNA. Based on the obtained MD results ILs enter into the solvation shell of the DNA and push away the water molecules from the DNA surface. Structural analysis shows that [BMIM]+ cations can occupy the DNA minor groove without disturbing the double-helical structure of DNA. ILs due to strong electrostatic and van der Waals (vdW) interactions with the DNA structure contribute to the stability of the double-helical structure. Quantum chemistry calculations indicate that the interactions between the [BMIM]+ cation and DNA structure has an electrostatic character. Moreover, this cation forms a more stable complex with the CGCG region of the DNA in comparison with AATT base pairs. Overall, the results of this study can provide new insight into the application of ILs for maintaining DNA stability during long-term storage. Communicated by Ramaswamy H. Sarma Theoretical methods reveal that amino acid ionic liquids can be good candidates for increasing the stability of DNA in long-term storage.
Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway
Creators: name: Y. Chen
name: W. Qing
name: M. Sun
name: L. Lv
name: D. Guo
name: Y. Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Melatonin, an indolamine synthesized in the pineal gland, shows a wide range of physiological functions, and is under clinical investigation for expanded applications. Melatonin has demonstrated efficient protective effects against various types of oxidative damage in the liver system. This study investigates the protective effects of melatonin pretreatment on glycochenodeoxycholic acid (GCDCA)-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Melatonin markedly decreased mitochondrial ROS (mROS) production in L02 cells treated with 100 µM GCDCA, and inhibited GCDCA-stimulated cytotoxicity. Notably, melatonin exerted its hepatoprotective effects by up-regulating SIRT3 activity and its expression level, thus regulating SOD2 acetylation and inhibiting the production of mROS induced by GCDCA. Moreover, siRNA targeting SIRT3 blocked the melatonin-mediated elevation in mitochondrial function by inhibiting SIRT3/SOD2 signaling. Importantly, melatonin -activated SIRT3 activity was completely abolished by AMPK siRNA transfection. Similar results were obtained in rat with bile duct ligation (BDL). In summary, our findings indicate that melatonin is a novel hepatoprotective small molecule that functions by elevating SIRT3, stimulating SOD2 activity and suppressing mitochondrial oxidative stress at least through AMPK, and that SIRT3 may be of therapeutic value in liver cell protection for GCDCA-induced hepatotoxicity.
Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells
Creators: name: Chunlei Jin
name: Taichun Qin
name: Barton, Michelle Craig
name: Jelinek, Jaroslav
name: Issa, Jean-Pierre J
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Oxidation of 5-methylcytosine by TET family proteins can induce DNA replication-dependent (passive) DNA demethylation and base excision repair (BER)-based (active) DNA demethylation. The balance of active vs. passive TET-induced demethylation remains incompletely determined. In the context of large scale DNA demethylation, active demethylation may require massive induction of the DNA repair machinery and thus compromise genome stability. To study this issue, we constructed a tetracycline-controlled TET-induced global DNA demethylation system in HEK293T cells. Upon TET overexpression, we observed induction of DNA damage and activation of a DNA damage response; however, BER genes are not upregulated to promote DNA repair. Depletion of TDG (thymine DNA glycosylase) or APEX1 (apurinic/apyrimidinic endonuclease 1), two key BER enzymes, enhances rather than impairs global DNA demethylation, which can be explained by stimulated proliferation. By contrast, growth arrest dramatically blocks TET-induced global DNA demethylation. Thus, in the context of TET-induction in HEK293T cells, the DNA replication-dependent passive mechanism functions as the predominant pathway for global DNA demethylation. In the same context, BER-based active demethylation is markedly restricted by limited BER upregulation, thus potentially preventing a disastrous DNA damage response to extensive active DNA demethylation.
Local delivery of a selective androgen receptor modulator failed as an anabolic agent in a rat bone marrow ablation model
Creators: name: Aro, Hannu T
name: Kulkova, Julia
name: Moritz, Niko
name: Kähkönen, Esa
name: Mattila, Riina H
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: Genetics
subject: Medicine
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Background and purpose — Selective androgen receptor modulators (SARMs) have been developed to have systemic anabolic effects on bones and muscles without the adverse effects of steroidal androgens. One unexplored therapeutic option is the targeted application of SARMs for the enhancement of local new bone formation. We evaluated the osteogenic efficacy of a locally released SARM (ORM-11984).Methods — ORM-11984 was mixed with a copolymer of L-lactide and ɛ-caprolactone (PLCL). An in vitro dissolution test confirmed the sustainable release of ORM-11984 from the matrix. A bone marrow ablation model was used in female Sprague-Dawley rats. Implants containing 10%, 30%, or 50% ORM-11984 by weight or pure PLCL were inserted into the medullary canal of the ablated tibia. At 6 and 12 weeks, the volume of intramedullary new bone and the perimeter of bone-implant contact were measured by micro-computed tomography and histomorphometry.Results — Contrary to our hypothesis, there was a negative correlation between the amount of new bone around the implant and the dose of ORM-11984. There was only a mild (and not statistically significant) enhancement of bone formation in ablated bones subjected to the lowest dose of the SARM (10%).Interpretation — This study suggests that intramedullary/endosteal osteogenesis had a negative, dose-dependent response to locally released SARM. This result highlights the complexity of androgenic effects on bones and also suggests that there are biological limits to the targeted local application of SARMs.
The accuracy of clinical prediction of prognosis for patients admitted with sepsis to internal medicine departments
Creators: name: Ghanem-Zoubi, Nesrin
name: Bitterman, Haim
name: Laor, Arie
name: Yurin, Vitaly
name: Vardi, Moshe
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Cancer
Biological Sciences
Earth and Environmental Sciences
Biotechnology
Medicine

description: Introduction: Prognosis estimation offered by physicians for patients inflicted by sepsis on their admission to Internal Medicine (IM) departments is considered a challenge. Early prognosis estimation is critical and determines the intensity of treatment offered. The accuracy of prognosis estimation made by physicians has previously been investigated mainly among intensive care physicians and oncologists.Objective: To ascertain the accuracy of prognosis prediction made by internists for septic patients on admission to IM departments.Methods: Physicians were asked to estimate the prognosis of every patient identified to have sepsis on admission. Their intuitive assessment of prognosis was incorporated into the patients’ electronic medical record. Survival follow-up was recorded until death or for at least 2 years. Later we compared survival with physicians’ prognosis estimations.Results: Prognosis estimation was recorded for 1,073 consecutive septic patients admitted throughout the years 2008–2009 to IM departments. The mean age of patients was 74.7 ± 16.1 years. A total of 42.4% were suspected to have pneumonia, and 65.4% died during a mean follow-up time of 661.1 ± 612.3 days. Almost half of the patients classified to have good prognosis survived compared to 14.9% and 4.9% of those with intermediate and bad prognosis estimation, respectively (P Conclusion: Internists can discriminate well between septic patients with good, intermediate, and bad prognosis.Key messagesMany patients suffering from sepsis are treated at general medical departments.Good estimation of the severity of disease upon admission is critical for decision-making regarding treatment.Internists including junior staff could discriminate well between patients with different degrees of disease severity of sepsis.
ThinkFree: Using a visual wiki for IT knowledge management in a tertiary institution
Creators: name: Hirsch, Christian
name: Hosking, John
name: Grundy, John
name: Chaffe, Tim
Publisher: name: Swinburne
Year: 2024

description: We describe ThinkFree, an industrial Visual Wiki application which provides a way for end users to better explore knowledge of IT Enterprise Architecture assets that is held within a large enterprise wiki. The application was motivated by the difficulty users were facing navigating and understanding enterprise architecture information in a large corporate wiki. ThinkFree provides a graph based interactive visualization of IT assets which are described using the Freebase semantic wiki. It is used to visualize relationships between those assets and navigate between them. We describe the motivation for the development of ThinkFree, its design and implementation. Our experiences in corporate rollout of the application are discussed, together with the strengths of weaknesses of the approach we have taken and lessons learned from ThinkFree's development and deployment.
Molecular mechanisms of drug resistance and its reversal in cancer
Creators: name: Kartal-Yandim, Melis
name: Adan-Gokbulut, Aysun
name: Baran, Yusuf
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Chemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The resistance phenotype is associated with the tumor cells that gain a cross-resistance to a large range of drugs that are structurally and functionally different. Multidrug resistance arises via many unrelated mechanisms, such as overexpression of energy-dependent efflux proteins, decrease in uptake of the agents, increase or alteration in drug targets, modification of cell cycle checkpoints, inactivation of the agents, compartmentalization of the agents, inhibition of apoptosis and aberrant bioactive sphingolipid metabolism. Exact elucidation of resistance mechanisms and molecular and biochemical approaches to overcome multidrug resistance have been a major goal in cancer research. This review comprises the mechanisms guiding multidrug resistance in cancer chemotherapy and also touches on approaches for reversing the resistance.
Alcohol mixed with energy drink (AMED): A critical review and meta-analysis
Creators: name: Verster, Joris
name: Benson, Sarah
name: Johnson, Sean J.
name: Alford, Chris
name: Godefroy, Samuel Benrejeb
name: Scholey, Andrew
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 520201
subject: Behavioural genetics
classificationCode: 520202
subject: Behavioural neuroscience
classificationCode: 520203
subject: Cognitive neuroscience
classificationCode: 520205
subject: Psychopharmacology
classificationCode: 520206
subject: Psychophysiology
classificationCode: 520207
subject: Social and affective neuroscience
classificationCode: 520301
subject: Clinical neuropsychology
classificationCode: 520401
subject: Cognition
classificationCode: 520403
subject: Learning, motivation and emotion

description: The purpose of this systematic review and meta-analysis was to critically review the (1) prevalence of alcohol mixed with energy drink (AMED) consumption, (2) motives for AMED consumption, (3) correlates of AMED consumption, and (4) whether AMED consumption has an impact on (a) alcohol consumption, (b) subjective intoxication, and (c) risk-taking behavior. Overall a minority of the population consumes AMED, typically infrequently. Motives for AMED consumption are predominantly hedonistic and social. Meta-analyses revealed that AMED consumers drink significantly more alcohol than alcohol-only (AO) consumers. Within-subject comparisons restricted to AMED consumers revealed that alcohol consumption does not significantly differ between typical AMED and AO occasions. On past month heaviest drinking occasions, AMED users consume significantly less alcohol on AMED occasions when compared to AO occasions. AMED consumers experience significantly fewer negative consequences and risk-taking behavior on AMED occasions compared with AO occasions. Meta-analyses of subjective intoxication studies suggest that AMED consumption does not differentially affect subjective intoxication when compared to AO consumption. In conclusion, when compared to AO consumption, mixing alcohol with energy drink does not affect subjective intoxication and seems unlikely to increase total alcohol consumption, associated risk-taking behavior, nor other negative alcohol-related consequences. Further research may be necessary to fully reveal the effects of AMED.
Oxynoemacheilus zagrosensis Kamangar, Prokofiev, Ghaderi & Nalbant 2014
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Nemacheilidae
Oxynoemacheilus
Oxynoemacheilus zagrosensis

description: 45. Oxynoemacheilus zagrosensis Kamangar, Prokofiev, Ghaderi & Nalbant, 2014
Common name. Zagros stone loach
Taxonomy. Original description: Oxynoemacheilus zagrosensis Kamangar, Prokofiev, Ghaderi & Nalbant, 2014: 43, fig. 4 [Shooei River (Jemli, sta. 9), Baneh, Kurdistan, Iran, 35°58'01"N, 45°42'43"E; holotype: FCFUK 101].
Revisions. None.
Illustrations. Kamangar et al. (2014: 43, fig. 4).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Loch mahi-e Zagros.—Recorded from Iran in the original description by Kamangar et al. (2014); listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: FCFUK, ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 21, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
MANBALARDA BOBURIY PODSHOH AVRANZEB OLAMGIR IJODIY FAOLIYATINING YORITILIShI
Creators: name: Sherxon QORAYEV, Qarshi irrigatsiya va agrotexnologiyalar instituti dotsenti (PhD).
Publisher: name: Zenodo
Year: 2024

description: Abdul Muzaffar Muhyiddin Muhammad Avrangzeb Bahodir Olamgir (1619 -1707) ham bobokaloni Sohibqiron Temur kabi o’z majlislarida o‘z o‘rni va o‘z vaqtida she’rlar o‘qigan, hikmatli so‘zlar aytgan. Avrangzeb “Taxt ziynati”, “Taxt bezagi”, olamgir esa “Olamning sayyidi”, “Olamni isloh qiluvchi” demakdir.[1] Abulhasan Nadaviy o‘zining “Maza xosaro al-alam binhitotil muslimin” kitobida boburiy hukmdor haqida shunday yozgan: “U temuriy podshohlarning eng kuchlilaridan biri edi.

[1] https://oliymahad.uz/5018
Risk of ischemic stroke in patients with systemic sclerosis: A systematic review and meta-analysis
Creators: name: Patompong Ungprasert
name: Anawin Sanguankeo
name: Sikarin Upala
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Medicine

description: Background. Several chronic inflammatory disorders, such as rheumatoid arthritis and idiopathic inflammatory myositis, have been shown to increase risk of ischemic stroke but the data on systemic sclerosis (SSc) remains unclear.Methods. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing risk of ischemic stroke in patients with SSc versus non-SSc participants. Pooled risk ratio and 95% confidence intervals (CIs) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.Results. Four retrospective cohort studies were identified and included in our data analysis. We found a statistically significant elevated ischemic stroke risk in patients with SSc with a pooled risk ratio of 1.68 (95% CI, 1.26–2.24). The statistical heterogeneity was moderate with an I2 of 69%.Conclusions. Our study demonstrated a statistically significant increased ischemic stroke risk among patients with SSc.