cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ОСОБЕННОСТИ ИНТЕЛЛЕКТУАЛЬНО-МНЕСТИЧЕСКОЙ СФЕРЫ У БОЛЬНЫХ ПАРАНОИДНОЙ ШИЗОФРЕНИЕЙС СОПУТСТВУЮЩИМИ ВИРУСНЫМИ ГЕПАТИТАМИ
Creators: name: Асадов, Асатилло
name: Муртазаева, Элеонора
name: Джуракулова, Диёра
name: Гиясова, Нигора
Publisher: name: Zenodo
Year: 2024

description: по данным ВОЗ, в последние десятилетия нарастание нейрокогнитивного дефицита у больных параноидной шизофрениейявляется одной из важнейших медико-социальных проблем современной психиатрии. Медико-социальная значимость проблемы заключается в том,что среди больных шизофренией значительный удельный вес составляют лица трудоспособного возраста, а также достаточно высокий процент ихинвалидизации.
Anti-inflammatory and pro-healing activities of HYCOs, novel Nrf2/HO-1 activators that simultaneously release carbon monoxide
Creators: name: El Ali, Zeina
name: Ollivier, Anthony
name: Surenaud, Mathieu
name: Martens, Thierry
name: Rivard, Michael
name: Motterlini, Roberto
name: Foresti, Roberta
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Oxidative stress and inflammation are constant features of many chronic disorders including skin diseases and diabetes hence the need to develop efficient therapeutic approaches. We are currently working on drug discovery targeting the nuclear factor-erythroid-2-related-factor 2 (Nrf2), a transcription factor controlling the expression of detoxifying and cytoprotective genes, including heme oxygenase-1 (HO-1). It has previously showed that the delivery of carbon monoxide (CO) via CO-releasing molecules (CO-RMs) diminishes tissue injury caused by inflammation and oxidative stress.  Here we report the characterization of novel molecules activating Nrf2/HO-1 and simultaneously releasing CO. These compounds termed hybrid CO-RMs (HYCOs) were obtained by coordinating a CO-RM moiety to a fumaric ester, a known Nrf2/HO-1 inducer. Fourteen HYCOs were characterized in vitro using human THP-1 monocytes and HaCaT keratinocytes. Five among the 14 compounds tested were able to significantly induce Nrf2/HO-1 and release CO in both cell types. Furthermore, three HYCOs decreased the production of pro-inflammatory markers in THP-1 cells challenged with lipopolysaccharide. When an in vitro wound was created in keratinocytes, two HYCOs accelerated wound closure in a concentration-dependent manner.
 These data suggest that HYCOs possess anti-inflammatory and reparative properties which will be studied in animal models of skin wound healing.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Identification of important regulatory elements using multi-level matrix factorization approaches
Creators: name: Merlevede, Jane
name: Zinovyev, Andrei
name: Armengol, Carolina
name: Carrillo-Reixach, Juan
name: del Rio, Alvaro
name: Sumazin, Pavel
Publisher: name: Zenodo
Year: 2021
Subjects: Unsupervised deconvolution
Matrix factorization
Multiomics data integration
Data integration
Meta-analysis

description: This is the accepted iPC deliverable D3.1 "Identification of important regulatory elements using multi-level matrix factorization approaches". D3.1 describes the techniques for dimensionality reduction used in iPC and their application to a selection of cohorts (at different omics levels) as well as a meta-analysis of the four solid tumor types of interest. The goal of the deliverable is to provide a list of pathways and biological functions having a key role in multiple paediatric cancers.
Some information is too dangerous to be on the internet
Creators: name: Müller, Vincent C.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: This paper investigates a problem about freedom of information. Although freedom of information is generally considered desirable, there are a number of areas where there is substantial agreement that freedom of information should be limited. After a certain ordering of the landscape, I argue that we need to add the category of 'dangerous' information and that this category has gained a new quality in the context of current information technology, specifically the Internet. This category includes information the use of which would be morally wrong as well as some of what may be called 'corrupting' information. Some such information should not be spread at all and some should be very limited in its spread.
Supplementary document for Optical Microscopy with Large Tilt Angle and Long Focus Length for a Nano-size Angle Resolved Photoemission Spectroscopy - 6062104.pdf
Creators: name: Yue, Chenyang
name: Jiang, Hong
name: Guo, Chuan
name: Li, Tianzhi
name: Yao, Siyan
name: Zhang, Shuo
name: Zhang, Dan
name: Zeng, Shenyue
name: Wang, Meixiao
name: Xu, Xiaojun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary materials
title: Rede zum Herbstbott 2004
title: Jahresbericht / Gottfried Keller-Gesellschaft (1994-2006)
titleType: AlternativeTitle
title: Dreiundsiebzigster Jahresbericht (Gottfried Keller-Gesellschaft)
titleType: Subtitle
Creators: name: Jauch, Ursula Pia
Publisher: name: Verlag der Gottfried Keller-Gesellschaft
Year: 2005
Subjects: subject: 800 Literatur und Rhetorik
subject: Keller, Gottfried
subject: Gottfried Keller-Gesellschaft
subject: Bericht
subject: Rede
subject: Deutsche Literatur
subject: Rathaus Zürich
subject: Feuerbach, Ludwig

description: Enthält die Gottfried Keller-Bibliographie für den Zeitraum 2002-2005
description: Enthält ausserdem den Nachruf "Ein Gottfried Keller-Freund - Fritz Jäggli zum Gedenken"
description: Rede «Gottfried Keller trinkt Bier mit Ludwig Feuerbach und 'Gott hält sich mäuschenstill' - vom vermeintlichen Verlust des frommen Gemüts» von Ursula Pia Jauch, gehalten am Jahresbott der Gottfried Keller-Gesellschaft am im Rathaus Zürich
Governance and public value Report - Producing Value through the Moving Images: An Analysis of Public Value and its Cultural Contribution to the strength and competitiveness of the European film sector.
Creators: name: Sarikakis, Katharine
name: Ramadani, Gentiana
name: Juengst, Janina
name: Chatziefraimidou, Angeliki
Publisher: name: Zenodo
Year: 2024
Subjects: Public value, film industry, definition

description: This document analyses public value as a termin the film industry by stating the definition andconducting interviews
Limnocoris woytkowskii La Rivers 1970
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Limnocoris
Limnocoris woytkowskii

description: Limnocoris woytkowskii La Rivers, 1970
 Geographic distribution. Ecuador (Rodrigues & Sites 2021), Peru (La Rivers 1970).
 Distribution in Peru. Huánuco (La Rivers 1970).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 37, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Use of UK/US common law contract law in international business contracts in Southeast Asia Empirical Evidence from Telecoms & Engineering
Creators: name: Rendon, Mark
Publisher: name: AJMI
Year: 2016
Subjects: International contracts, Southeast Asia, ASEAN, Common law, Civil Law, business development, corporate development, negotiation, UNIDROIT

description: 1, 3, ASEAN Journal of Management and Innovation
Improvement of Oxidative Stress Reverses Dysfunctions of Human Visceral Adipose-derived Stem Cells
Creators: name: Sugii, Shigeki
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Central obesity, characterized by expansion of visceral (VS) fat, is highly correlated with metabolic complications. Although VS depot differs from subcutaneous (SC) depot in its pathophysiological contributions, little is known about its molecular and functional basis. In this study, we isolated adipose-derived stem cells (ASCs) from SC and VS fat of at least 10 human subjects and found that levels of reactive oxygen species (ROS) and reactive nitrogen species are higher in VS-ASCs when compared to SC-ASCs. Microarray analysis and further validation by qPCR revealed that SC-ASCs have higher expression of genes involved in anti-oxidant and anti-inflammatory pathways, while VS-ASCs exhibit more genes in pro-oxidant and pro-inflammatory pathways. Treatment anti-oxidants, such as Vitamin C, decreased ROS levels drastically in both SC- and VS-ASCs, with the reduction being more prominent in the VS-ASCs. Vitamin C treatment substantially improved proliferation, senescence, migration, and adipogenic capacities of VS-ASCs caused by higher ROS. We identified xanthine oxidase and NADPH oxidase as major mediators of these processes. These findings establish fat depot specific differences in redox capacity of stem cells, potentially offering a strategy in reversing central obesity by improving ROS and compromised adipogenic function of VS fat.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Predictive Cognitive Loads for Online Learners with AI Eye Tracking
Creators: name: Šola, Dr. Hedda Martina
name: Khawaja, Sarwar
name: Qureshi, Fayyaz Hussain
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 380102
subject: Behavioural economics
classificationCode: 390303
subject: Higher education
classificationCode: 350601
subject: Consumer behaviour
classificationCode: 350608
subject: Marketing theory
classificationCode: 460299
subject: Artificial intelligence not elsewhere classified

description: This research is part of the article "AI Eye-Tracking Technology: A New Era in Managing Cognitive Loads for Online Learners," which has been accepted for publication in the top-tier Education Sciences Journal.  
Website: https://www.mdpi.com/2227-7102/14/9/933
PDF Version: https://www.mdpi.com/2227-7102/14/9/933/pdf
Quantitative analysis of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells to understand and inform treatment design
Creators: name: Deeni, Yusuf Yahaya
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Reactive oxygen species (ROS) exacerbate oxidative stress (OS) on cells and impact cell fate, including proliferation. Research has highlighted the role of the trans-acting regulator NRF2, which drives the transcription of genes associated with redox homeostasis. We propose that ROS manipulation could control proliferation depending on cell line and net redox status, which requires accurate quantification. We explored this and the role of NRF2 by profiling proliferation under normal and perturbed redox status for a panel of ovarian cell lines, and observed a significant correlation between proliferation ROS level and nuclear or cytoplasmic NRF2 localisation. Then to understand the mechanism of redox regulation we used our experimental data and other literature data to construct a mathematical model of the key response mechanisms to OS. We showed that cellular responses to OS are governed by a NRF2-KEAP1 dependent mechanism that is cell line specific. The fast dynamic redox regulation in this region most likely allows cancerous cells to maintain high level of endogenous ROS for proliferative advantage and to overcome OS. Furthermore, we identified cross-talk between ROS, NRF2 and HER family receptors and hypothesise that NRF2 sets the limit and effectiveness of receptor tyrosine kinase (RTK) inhibitors in anticancer therapy.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Muslim Students Association of the United States and Canada
Creators: name: Tareen, SherAfgan
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Muslim Students Association of the United States and Canada (popularly known as MSA) is a network of Muslim communities that gather at and draw their support from college campuses. The history of the MSA dates back to the early sixties, a time period when Muslim migrants from the MENA (Middle East North Africa) region, South Asia, and Far East Asia migrated in large numbers to the United States in pursuit of graduate training in STEM fields and humanities. The earliest conventions of the MSA were held on college campuses in the Midwest region, including the University of Illinois campus in Champaign- Urbana. While majority of the MSA presidents were male graduate students, their wives played an even greater role in the growth of the Muslim Students Association by establishing the Women’s Committee of the Muslim Students Association. One of the key ritual practices of the Muslim Students Association is the Quran Study Circle. It had been organized on college campuses such as Karachi University, Pakistan long before the pioneers of the Muslim Students Association migrated to the United States. Through discussing commentaries on the Quran collectively, students sought to upend the separation of religion from higher education that had been brought forth by colonization and elevate Islam as a methodological hook for an integrative model of learning. In the United States, the Quran Study Circle addressed the shared concerns of women around childrearing. Its participants were the pioneers of the Women’s Committee of the MSA. They gathered at each other’s homes and leveraged the Quran as a prompt for discussing shared experience of parenting and raising young Muslim children in suburban and ex-urban landscapes where there had been no existing institutional presence of Islam. These conversations inspired the growth of the North American Islamic School Movement. Examples include Al-Fatih Academy, a K-8th grade Islamic School that offers an integrative model of education with hopes of helping its student body learn to cognize their emotions. In addition to the development of Islamic schools, the Muslim Students Association also gave birth to the Islamic Society of North America (ISNA). Located in Plainfield, Indiana, ISNA seeks to elevate Islam and uplift Muslim-American communities through interfaith dialogue and civic engagement. One of the enduring hallmarks of the Muslim Students Association has been a distinctively feminine approach to activism centered around building relationships and cultivating emotional connection across religious, national, and racial lines of difference. MSA’s commitment to a transnational ummah/community is best exemplified by the deep bonds of friendship and camaraderie between the movement’s pioneers that endure to this day.
„Non-invasive!” An interdisciplinary conference concerning the digital in conservation-restoration — once again in person! A résumé
Creators: name: Schädler-Saub, Ursula
Publisher: name: Hornemann Institut
Year: 2022
Subjects: Preventive conservation

description: Under the motto „Non-Invasive!”, the HAWK Faculty of Architecture, Engineering and Conservation and the Hornemann Institute organised an interdisciplinary conference in Brandenburg an der Havel from 27 to 30 April. The HAWK in Hildesheim cooperated with the Brandenburg State Office for the Preservation of Monuments and the Brandenburg State Archaeological Museum and with the Brandenburg Cathedral Abbey. The text summarises the contents and results of the conference.
A sub-population of primary AML blasts shows resistance to oxidative stress and reduced p38MAPK activation
Creators: name: Hole, Paul S.
name: Davies, Sara
name: Kreuser, Sandra
name: Omidvar, Nader
name: Tonks, Alex
name: Darley, Richard L.
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Over-production of NOX-derived ROS is common in acute myeloid leukaemia (AML) and correlates with reduced responsiveness of the stress-activated kinase, p38MAPK.  We hypothesized that leukaemia cells regulate ROS accumulation in order to evade p38MAPK activation, which might otherwise compromise their proliferation or survival.  Here we show that p38MAPK signalling is suppressed in a sub-population of cells observed in nearly all primary AML patients and AML cells which we have termed ‘delta’ cells.  Consistent with our hypothesis, delta cells are highly resistant to exogenous oxidative stress.  Resistance to oxidative stress in delta cells was not due to differences in anti-oxidant capacity, but rather due to restricted entry of H2O2 through the plasma membrane.  Pharmacological studies using inhibitors of the aquaporin protein family suggested that members of this family governed H2O2 entry in delta cells. Expression of AQP3, a reported H2O2 -permeable member of the aquaporin family, correlated with H2O2 permeability in a panel of AML cell lines. We are currently testing the hypothesis that lowered AQP3 expression mediates the resistance of delta cells to oxidative stress.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Curicta peruviana Kuitert 1949
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Nepidae
Curicta
Curicta peruviana

description: Curicta peruviana Kuitert, 1949
 Geographic distribution. Peru (Kuitert 1949).
 Distribution in Peru. Junín (Kuitert 1949).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 37, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
ПРОБЛЕМНАЯ СИТУАЦИЯ КАК СОСТАВЛЯЮЩЕЕ ЗВЕНО УЧЕБНО-ИССЛЕДОВАТЕЛЬСКОЙ РАБОТЫ
Creators: name: Ризакулова, Рухшона
name: Азимова, Азиза
name: Белялова, Лиана
name: Гиясова, Нигора
Publisher: name: Zenodo
Year: 2024

description: За последние годы неоднократно менялись программы преподавания дисциплин в высших школах и программа преподаваниянормальной анатомии человека в частности. Интерес к методологии преподавания предмета занимает ключевой момент в учебных программах высшей школы. На сегодняшний день главным направлением является личностный подход, который формирует активную личность студента, которыйумеет свободно оперировать полученными знаниями, применять их для решения ситуационных клинических задач. Эти требования касаются, в первуюочередь, студентов младших курсов, ведь на старших курсах методики обучения и получения знаний значительно усложняются и приближаются креалиям клиники.
Activité antioxydante et antibactérienne des huiles essentielles et flavonoïdes extraites à partir de plantes médicinales de la région de Mascara
Creators: name: Fadela, Boukada Rahmani
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: La réponse du système immunitaire suite à une infection s'accompagne avec la production des radicaux libres et la génération du stress oxydatif. C'pourquoi, la molécule antibactérienne  doit être une molécule antioxydante. Pour cette raison, on a essayé dans le présent travail, d'évaluer l'effet antioxydant et antibactérien des substances actives d'Ajuga iva, Adiantum capilus-veneris, Lavandula stoechas.

Les huiles essentielles et flavonoïdes sont extraites par hydrodistillation et des solvants à polarité croissante où on a obtenu plusieurs fractions, qui sont analysées par chromatographie sur couche mince. Cette dernière a montré que les extraits sont trés riches en flavonoïdes.

Le potentiel antioxydant esr évalué par trois méthodes: piégeage des radicaux DPPH, réduction de fer et le test de péroxydation lipidique. L'évaluation de l'activité antibactérienne a été faite par la méthode de diffusion sur disque, et les produits qui semblent actifs, ont fait l'objet d'une évaluation de leur activité pour déterminer la concentration minimale inhibitrice et la concentration minimale bactéricide.

Les extraits flavoniques ont révélé un effet antioxydant trés élevé et réduisent le radical DPPH jusqu'à 90%. En parallèle, les huiles essentilles présentent un pouvoir antibactérien trés important.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Change in the antioxidative capacity of extraocular muscles in patients with exotropia
Creators: name: Shin, Sun Young
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Aims: We compared the oxidative stress and antioxidant capacities of the medial rectus muscles (MRMs) of control subjects and those with exotropia.
Methods: A total of 40 MRMs from patients with exotropia and 40 MRMs from normal donor eyes (controls) were assessed. The mRNA levels of neuronal nitric oxide synthase (nNOS) and superoxide dismutase (SOD) were compared between the two groups using semi-quantitative reverse transcription-polymerase chain reaction. In addition, SOD1, SOD2, and lipofuscin levels were compared between the exotropic and control groups.
Results: nNOS mRNA level was significantly higher in the exotropic group than in the control group (p < 0.001). Western blot analysis revealed that SOD1 and SOD2 expression levels were higher in the control group than in the exotropic group (p < 0.05). The relative lipofuscin fluorescence intensity was higher in the exotropic group than in the control group (p < 0.001).
Conclusion: The MRMs of patients with exotropia had a redox imbalance status. Further study is needed to investigate whether this imbalance in antioxidant capacity is present in the extraocular muscles of other patients with strabismus.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Role of mitoNEET in the control of cellular iron homeostasis, a novel drug target for mitochondrial dysfunction
Creators: name: Ferecatu, Ioana
name: Gonçalves, Sergio
name: Golinelli-Cohen, Marie-Pierre
name: Clémancey, Martin
name: Martelli, Alain
name: Riquier, Sylvie
name: Latour, Jean-Marc
name: Puccio, Hélène
name: Lescop, Ewen
name: Bouton, Cécile
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Iron-sulfur (Fe-S) cluster-containing proteins are essential for life, notaby by sustaining photosynthesis, nitrogen fixation and oxidative respiration. In mammals, mitoNEET is a N-terminally anchored Fe-S protein of the outer mitochondrial membrane and a novel target of the drug diabetes pioglitazone. Although its function is still unknown, biophysical studies suggest that mitoNEET participates in a redox-sensitive signaling and/or in Fe-S transfer. By performing loss-of-function studies in living cells and in vivo, we showed that lifespan of mitoNEET in its native environment is dependent on the mitochondrial iron-sulfur cluster (ISC) assembly and export machineries but not on the cytosolic Fe-S cluster (CIA) machinery. Moreover, we identified a dedicated ISC/export pathway in which Augmenter of Liver Regeneration (ALR) is specific to mitoNEET maturation. In vitro biochemical and biophysical studies revealed that mitoNEET Fe-S cluster confers folding and stability. In living cells, the holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of iron homeostasis that has been involved in the mitochondrial iron supply. Therefore, our findings point to IRP1 as the missing link explaining the function of mitoNEET in the control of mitochondrial iron homeostasis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Supplementary document for Visualization of transparent particles based on optical spatial differentiation - 6062379.pdf
Creators: name: He, Shanshan
name: wang, Ruisi
name: xu, wenhao
name: Luo, Zhao
name: Luo, Hailu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Explanation about the innovations of our theoretical model
Microbial cells can cooperate to resist chronic ionizing radiation
Creators: name: Shuryak, Igor
name: Matrosova, Vera
name: Gaidamakova, Elena
name: Tkavc, Rok
name: Daly, Michael
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Understanding chronic ionizing radiation (CIR) effects is crucial for predicting impacts of occupational exposures and radionuclide releases. Extrapolation of acute-radiation responses to CIR is unreliable. We investigated how cells resist/mitigate CIR by: (1) exposing bacteria (four Escherichia coli strains and Deinococcus radiodurans) and fungi (6 different species) to chronic g-radiation (0-180 Gy/h); (2) developing a mechanistically-motivated mathematical model to analyze these data. The most resistant organisms (D. radiodurans, E. coli CB1000, Trichosporon mucoides) proliferated at ≥67 Gy/h. Cell concentration strongly modulated the radioresistance of some bacteria. For example, the growth-inhibitory dose rate for D. radiodurans increased from 67 to >126 Gy/h, when the inoculum increased from 103 to ~108 cells/ml. Therefore, some radioresistant microbial cells cooperate to withstand CIR. Our model, based on the hypothesis that proliferation under CIR depends on ROS detoxification rate, provided an explanation for these data: At dose rates below a critical threshold, ROS concentrations remain low enough to allow proliferation. Above the threshold, cells cannot detoxify ROS quickly enough and proliferation is inhibited. We suggest that at high cell concentrations the threshold increases due to enhancement of extra-cellular ROS detoxification. These novel findings have potential implications for predicting/mitigating CIR impact on human cells.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
ATM is required for SOD2 Expression
Creators: name: Dyer, Lisa M
name: Kepple, Jessica
name: Ai, Lingbao
name: Brown, Kevin D
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
On the Body and Blood of the Lord (De corpore et sanguine Domini) - Paschasius Radbertus
Creators: name: Luginbill, Sarah
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: One of the earliest complete treatises on the Eucharist, Paschasius Radbertus' De corpore contained twenty-two chapters, each answering a specific question related to the Eucharist, and included references and excerpts from the works of the early church fathers and to scripture. Radbertus (c.785-c.865) was a Carolingian theologian and Benedictine monk at the abbey of Corbie in northern France. Around 833, Radbertus first wrote the De corpore and dedicated it to Warin, his former pupil and fellow monk at Corbie, who had traveled to the newly established abbey of Corvey in Saxony and become its abbot. According to Radbertus’ prologue, Warin requested a short work on the Eucharist for his new community on the edge of Christendom. In late 843, shortly after Radbertus became abbot of Corbie, he revised and rededicated the De corpore to Charles the Bald, King of the Franks. This second edition included several miracle stories surrounding the Eucharist that did not appear in the first version, as well as a new dedicatory prologue to the king. Throughout the De corpore, Radbertus argued that the Eucharistic bread and wine were the literal body and blood of Christ and not merely symbols of it. Radbertus opened the entire text with a chapter explicitly about this issue. The De corpore also addresses specific aspects of the celebration of the Mass, including the use of ritual objects, and Old Testament precedents for Christ’s suffering.
Supplementary document for Unsupervised segmentation of biomedical hyperspectral image data: tackling high dimensionality with convolutional autoencoders - 6062383.pdf
Creators: name: Bench, Ciaran
name: Nallala, Jayakrupakar
name: Wang, Chun-Chin
name: Sheridan, Hannah
name: Stone, Nicholas
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
Science and decolonisation
Creators: name: Kajee, Mohammed
name: Taylor, Dale
name: Lupuwana, Vuyiswa
name: Sithaldeen, Riashna
name: Ackermann, Rebecca
name: Tutu, Akha
name: Fawcett, Sarah
Publisher: name: University of Cape Town
Year: 2024
Subjects: classificationCode: 390407
subject: Inclusive education

description: This chapter dives into science and decolonisation, dealing with important questions, such as: What does the word ‘decolonisation’ mean to you? What does it mean to decolonise science? As a young scientist in South Africa, do you know how colonisation has influenced science?
IS ANTIOXIDANT ACTIVITY OF WHEY PROTEIN MAINTAINED DURING UPPER GASTRIC TRANSIT?
Creators: name: Corrochano, Alberto Roman
name: Sariçay, Yunus
name: Brodkorb, André
name: Buckin, Vitaly
name: Kelly, Phil
name: Giblin, Linda
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Supplementation of food with antioxidants may help to reduce oxidative stress in the body. Whey proteins are widely used in various foods for their nutritional, health promoting and functional value. One of the health promoting attributes of whey is its antioxidant activity. The objective of this study was to determine whether commercial whey protein isolate (WPI) maintains its antioxidant activity during upper gut transit and to identify the main whey protein responsible for this bioactivity. Individual whey proteins (β-lactoglobulin, α-lactalbumin, bovine serum albumin and lactoferrin) and WPI were subjected to static in vitro gastrointestinal digestion (SGID). Antioxidant activity of the proteins, pre and post SGID, were measured and compared using various antioxidant assays (ORAC, ABTS and FRAP). To determine whether WPI could boost intracellular antioxidant levels in intestinal epithelial cells, CaCo2 cells were exposed to SGID whey and intracellular glutathione levels quantified. Whey proteins, particularly α-lactalbumin (21.0% ABTS inhibition), exhibit antioxidant activities which are further enhanced during gut transit (37.3% ABTS inhibition, P<0.05). However, glutathione levels in cells remain unchanged in the presence of SGID whey samples (P>0.05). In conclusion, whey proteins exhibit antioxidant activities but their ability to boost intracellular antioxidant status of cells remains to be determined.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
NASUNIN, THE MAJOR COMPONENT OF ANTHOCYANIN PIGMENT OF EGGPLANT, PROTECTS CULTURED MC3T3-E1 OSTEOBLASTIC CELLS AGAINTS OXIDATIVE STRESS.
Creators: name: Ceriotti, Serena
name: Casati, Lavinia
name: Stancari, Giovanni
name: Stucchi, Luca
name: Zucca, Enrica
name: Conturba, Bianca
name: Ferrucci, Francesco
name: Sibilia, Valeria
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the development of osteoporosis. Non-pharmacological measures, such as nutritional strategies that include antioxidant activities of food and vegetables, have been suggested to prevent age-related diseases. This study investigated whether nasunin, the major component of anthocyanin pigment of skin eggplant (Solanum melongena L), counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells. Pretreatment with purified nasunin (10-11 -10-5 M) increased viability and reduced apoptosis of MC3T3-E1 cells cultured with t-BHP (250 µM, 3h) and limited t-BHP induced reduction in osteoblast differentiation markers (alkaline phosphatase, collagen content). Furthermore, nasunin (10-9 M) prevented t-BHP-induced osteoblastic dysfunction and changes in the cytoskeleton organization due to both an increase of intracellular glutathione and a decrease of intracellular ROS. The nasunin-induced protective effects against t-BHP injury are mediated by the phosphoinositide 3-kinase (PI3K) /Akt signalling pathway since LY294002, a PI3K-specific inhibitor, worsened the cytotoxic effect of t-BHP and reversed the protective action of nasunin. Our results support nasunin as a possible valuable approach in the management of osteoblast dysfunction associated with oxidative stress, as occurs in osteoporosis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Ranatra macrophtalma Herrich-Schaffer 1849
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Nepidae
Ranatra
Ranatra macrophtalma

description: Ranatra macrophtalma Herrich-Schäffer, 1849
 Geographic distribution. Panama (Montandon 1907), Trinidad & Tobago (Hynes 1948), Colombia (Mayr 1866), Venezuela (Montandon 1907), Suriname (Mayr 1866), French Guiana, Brazil (Montandon 1907), Peru (Kirkaldy & Torre-Bueno 1909), Bolivia (Montandon 1905b), Paraguay (De Carlo 1946).
 Distribution in Peru. Unknown department (Kirkaldy & Torre-Bueno 1909).
 Notes. Originally described from “Ostindien?” (Herrich-Schäffer 1849), which was probably caused by mislabeling. Montandon (1905b) mentioned that specimens from Colombia and Suriname assigned to this species by Mayr (1866) could instead belong to R. robusta Montandon, 1905. De Carlo (1973) synonymized R. hungerfordi Kuitert, 1949 with R. macrophtalma in a short passage of his introduction, which was ignored by Keffer (2004). The same author and several others (e.g., Ribeiro et al. 2018) ignored the synonymy between R. sattleri De Carlo, 1967 and R. macrophtalma proposed by Roback & Nieser (1974). Nieser (1975) noted that the material from Paraguay reported by De Carlo (1946, 1964b) probably refers to another species.
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 38, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Étude de l’activité antioxydante et antimicrobienne des huiles essentielle et divers extraits d’Atriplex halimus et Centaurium erythraea
Creators: name: Soltani, Fatima Zohra Soltani Soltani Fatima Zohra
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Atriplex halimus et Centaurium erythraea, répandues en Algérie, sont deux plantes médicinales largement utilisées dans la médecine traditionnelle pour leurs propriétés thérapeutiques. Le présent  travail a pour objectif d'évaluer l'activité antioxydante et antimicrobienne d'extraits et des huiles essentielles de ces deux plantes.Les huiles essentielles sont extraites par hydrodistillation et les extraits sont préparés par macération dans différents solvants. l'extrait aqueux déodorisé est la phase aqueuse résiduelle de l'hydrodistillation. les extraits et les huiles essentielles sont ensuite soumis à une analyse phytochimique qualitative et/ou quantitative. l'activité antioxydante est évaluée par deux méthodes: La méthode au DPPH et la méthode FRAP. L'activité antimicrobienne est testée par la méthode de diffusion sur gélose, puis la CMI et la CMB/CMF des extraits actifs sont déterminées par la méthode de microdilution.
L'analyse phytochimique des extraits a montré la présence de différentes classes de métabolites secondaires.
A travers les deux tests d'évaluation de l'activité antiradicalaire, nous avons trouvé que nos extraits et huiles essentielles présentent une activité antioxydante. Les résultats de l'activité antimicrobienne ont montré l'efficacité des huilles essentielles et quelques extraits contre certaines souches testées.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
What do we really know about HNO reactivity? Implications for its fluorescence imaging in vivo.
Creators: name: Smulik, Renata
name: Mesjasz, Adrianna
name: Adamus, Jan
name: Sikora, Adam
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Nitroxyl (HNO, IUPAC name azanone), being formally the protonated product of one-electron reduction of nitric oxide (NO), is an elusive reactive nitrogen species possessing interesting biological chemistry and high pharmacological importance.1,2 Thiols, thiol proteins and metaloproteins are the most established biological targets for HNO.1-3 Contrary to nitric oxide, HNO is a strong electrophile highly reactive towards thiols, phosphines and nitroso compounds. A number of fluorescent probes for HNO detection based on the reaction of HNO with arylphosphines have been developed recently.
 Here, we present the study on the HNO reactivity towards selected HNO scavengers: thiols, arylphosphines (including profluorescent probe PCM) and nitroso compounds. In this study we applied previously described competition kinetics method4 based on two parallel, competing HNO reactions – with studied scavenger and with molecular oxygen. The latter, relatively fast reaction (k = (1.8 ± 0.3) ∙ 104 M-1s-1), results in the formation of peroxynitrite,4 that can be easily detected fluorometrically with the use of fluorogenic boronate probes.
 Potential implications for fluorescent imaging of HNO in cells using phosphine-based fluorogenic probes are discussed.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Hinweis auf einen Bericht des Max-Planck-Instituts für Aeronomie
Creators: name: Redaktion,
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1991

description: Elemente der Naturwissenschaft 55, p. 77-77.
description:
Kurzfassung. - Zwischen den Radien der Sonne, des Mondes und der Planeten sowie zwischen den großen Halbachsen der Planeten und deren natürlichen Satelliten bestehen ausnahmslos ziemlich einfache planimetrische Beziehungen. Sie gelten innerhalb der durch die Messungen bedingten Fehlergrenzen. Betrachtet man eine der astronomischen Größen als gegeben, z.B. den mittleren Radius der Erde, dann lassen sich alle übrigen Größen rechnerisch oder konstruktiv mittels Zirkel und Lineal davon ableiten. Ein gleichförmiges System wurde jedoch nicht gefunden; aber sämtliche planimetrischen Beziehungen enthalten nur Elemente, die bei der gleichmäßigen Teilung des Kreises auftreten, wobei nur das regelmäßige 3-, 4-‚ 5-‚ 6-, 8-, 10- und 20-Eck beteiligt sind, z.B. sin 22‚5° (8-Eck). Damit erweist sich als Prinzip der räumlichen Organisation unseres gesamten Planetensystems die gleichmäßige Teilung des Kreises. [...]

description:
Kurzfassung. - Zwischen den Radien der Sonne, des Mondes und der Planeten sowie zwischen den großen Halbachsen der Planeten und deren natürlichen Satelliten bestehen ausnahmslos ziemlich einfache planimetrische Beziehungen. Sie gelten innerhalb der durch die Messungen bedingten Fehlergrenzen. Betrachtet man eine der astronomischen Größen als gegeben, z.B. den mittleren Radius der Erde, dann lassen sich alle übrigen Größen rechnerisch oder konstruktiv mittels Zirkel und Lineal davon ableiten. Ein gleichförmiges System wurde jedoch nicht gefunden; aber sämtliche planimetrischen Beziehungen enthalten nur Elemente, die bei der gleichmäßigen Teilung des Kreises auftreten, wobei nur das regelmäßige 3-, 4-‚ 5-‚ 6-, 8-, 10- und 20-Eck beteiligt sind, z.B. sin 22‚5° (8-Eck). Damit erweist sich als Prinzip der räumlichen Organisation unseres gesamten Planetensystems die gleichmäßige Teilung des Kreises. [...]
Ranatra obscura Montandon 1907
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Nepidae
Ranatra
Ranatra obscura

description: Ranatra obscura Montandon, 1907
 Geographic distribution. Trinidad & Tobago (Nieser 1969b), Guyana (Nieser 1975), Suriname, French Guiana (Montandon 1907), Brazil (White 1879b), Peru (Montandon 1907).
 Distribution in Peru. Loreto? (Montandon 1907; see notes below).
 Notes. Material identified as R. annulipes Stål, 1854 by White (1879b) actually refers to this species (Nieser 1975). Montandon’s (1907) citation of “Amazone supérieur” probably corresponds to the region of Pebas, Loreto, Peru, as known for other specimens deposited in the Naturhistoriska riksmuseet (Stockholm, Sweden) bearing this label (Moreira et al. 2011).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 38, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Bird Communities Vary under Different Urbanization Types—A Case Study in Mountain Parks of Fuzhou, China
Creators: name: Xu, Weizhen
name: Fu, Weicong
name: Dong, Jiaying
name: Yu, Jiao
name: Huang, Peilin
name: Zheng, Dulai
name: Chen, Ziru
name: Zhu, Zhipeng
name: Ding, Guochang
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Bird habitats are becoming increasingly fragmented as a result of rapid urbanization. As one of the essential refuges for urban bird communities, mountain parks are of practical significance for studying the spatial changes of birds, which can inform the future planning of mountain park planning. In this study, we assessed the α, β, and functional diversity of bird communities in mountain parks in Fuzhou, China, at three levels of urbanization (urban, peri-urban, suburban) and explored how diversity (abundance, richness, α-diversity, Chao1) varies along the urbanization gradient. A three-month bird survey was conducted using the transect method to examine the impact of urbanization on bird community structures in mountain parks. In addition, we evaluated the functional diversity of bird guilds in order to identify potential indicator species for monitoring different urbanization gradients in mountain parks. The results showed that: (1) During the three bird surveys from December 2021 to February 2022, 96 bird species and 2429 individuals of 9 orders, 34 families, and 63 genera were identified. (2) Urbanization had a significant impact on the overall bird α-diversity (p = 0.040) and richness (p = 0.024) but not on the overall bird abundance (p = 0.056). (3) The results of non-metric multidimensional scaling showed significant variations among overall birds in mountain parks along with three urbanization levels (stress = 0.155, p = 0.027). Similarly, significant differences were observed in the upper-stratum guild (stress = 0.183, p = 0.049) but not in other diet and vertical foraging stratum guilds. (4) Five species were identified as potential candidates for monitoring the trends of urban gradients. Moreover, compared to insectivorous or omnivorous guilds, most carnivorous and herbivorous guilds may not be suitable for monitoring the negative effects of urbanization in mountain parks. Our findings can help inform urban mountain park management or restoration strategies intended to mitigate the adverse impacts of urbanization.
Protective effects of Quercetin and SRT1720 against D-Galactosamine/Lipopolysaccharide-induced hepatotoxicity; Role of Sirtuin 1 modulation
Creators: name: Kemelo, Mighty
name: Farghali, Hassan
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The plant flavonoid, quercetin, has powerful antioxidant properties and promising therapeutic potential against many types of liver insults. We have previously demonstrated its ameliorative effects against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) – induced hepatotoxicity, an experimental model that closely resembles acute liver failure. However, the notion that its cytoprotective effects are SIRT1 mediated is still controversial. In this study, we investigated whether SRT1720 (synthetic allosteric SIRT1 activator) may similarly attenuate D-GalN/LPS-induced hepatotoxicity. Male Wistar rats were randomly assigned into 6 groups: (1) Control, (2) Quercetin, (3) SRT1720, (4) D-GalN/LPS, (5) Quercetin + D-GalN/LPS and (6) SRT1720 + D-GalN/LPS. After twenty-four hours, the effects of these treatments were evaluated by biochemical studies, real-time PCR and Western blot. D-GalN/LPS treatment downregulated SIRT1 expression and drastically increased conjugated diene, bilirubin and aminotransferase levels. Both SRT1720 and quercetin pretreatments upregulated SIRT1 expression and significantly lowered the aforementioned markers. Quercetin had more profound effect on SIRT1 expression and was more effective in combatting the cytotoxic effects of D-GalN/LPS. Collectively, these results strongly suggest that pharmacologic modulation of SIRT1 expression could be an interesting therapeutic option against critical liver intoxication and requires further exploration.

This work was supported by PRVOUK-P25/LF1/2 and GAUK 916314.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Advanced glycation end products induce liver injury in non-alcoholic steatohepatitis (NASH) via hepatocyte NOX4
Creators: name: Jiang, Joy
name: Sato, Ai
name: Brandes, Ralph
name: Torok, Natalie
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: NASH is leading cause of liver injury, and patients with typeII DM are prone for aggressive disease. ROS play a key role in progression, and NOX4 is an important source of H2O2; but the mechanisms linking AGEs exposure to NOX4/RAGE signaling have been undefined. We hypothesized that circulating AGEs activate hepatocyte NOX4 via RAGE leading to progressive injury. RAGE was studied in patients with steatosis, or NASH/ DM; in hepatocyte-specific NOX4KOs (NOX4hepKO) and fl/fl controls following fast food diet (FFD). Liver AGEs and expression of detoxifying enzyme AGER1 were assessed. JNK1 phosphorylation, ROS, apoptosis were evaluated, and fibrosis assessed (fibrogenic transcripts, hydroxyl proline). In vitro, NOX4 promoter studies were done after AGEs exposure. Results: RAGE was induced in patients with DM/NASH (p<0.05), and in mice on FFD. In NOX4hepKO mice RAGE was downregulated (p<0.05), and ROS, lipid peroxidation, CHOP and JNK1 activation were attenuated, fibrosis improved (p<0.05). AGER1 was significantly lower in mice on FFD. BSA/AGEs induced NOX4 promoter activity/H2O2 release. Conclusion: AGEs-induced NOX4/H2O2 in hepatocytes leads to stress signals and downregulation of AGER1 further promotes liver fibrosis. Targeting AGEs/RAGE could thus be beneficial to improve outcomes.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)