cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Radiopacity Enhancements in Polymeric Implant Biomaterials: A Comprehensive Literature Review
Creators: name: Emonde, Crystal Kayaro
name: Eggers, Max-Enno
name: Wichmann, Marcel
name: Hurschler, Christof
name: Ettinger, Max
name: Denkena, Berend
Publisher: name: Washington, DC : ACS Publ.
Year: 2024
Subjects: subject: biocompatibility
subject: contrast agent
subject: implant
subject: polymers
subject: radiolucent
subject: radiopacity
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Polymers as biomaterials possess favorable properties, which include corrosion resistance, light weight, biocompatibility, ease of processing, low cost, and an ability to be easily tailored to meet specific applications. However, their inherent low X-ray attenuation, resulting from the low atomic numbers of their constituent elements, i.e., hydrogen (1), carbon (6), nitrogen (7), and oxygen (8), makes them difficult to visualize radiographically. Imparting radiopacity to radiolucent polymeric implants is necessary to enable noninvasive evaluation of implantable medical devices using conventional imaging methods. Numerous studies have undertaken this by blending various polymers with contrast agents consisting of heavy elements. The selection of an appropriate contrast agent is important, primarily to ensure that it does not cause detrimental effects to the relevant mechanical and physical properties of the polymer depending upon the intended application. Furthermore, its biocompatibility with adjacent tissues and its excretion from the body require thorough evaluation. We aimed to summarize the current knowledge on contrast agents incorporated into synthetic polymers in the context of implantable medical devices. While a single review was found that discussed radiopacity in polymeric biomaterials, the publication is outdated and does not address contemporary polymers employed in implant applications. Our review provides an up-to-date overview of contrast agents incorporated into synthetic medical polymers, encompassing both temporary and permanent implants. We expect that our results will significantly inform and guide the strategic selection of contrast agents, considering the specific requirements of implantable polymeric medical devices.
Unveiling the CO oxidation mechanism over a molecularly defined copper single‐atom catalyst supported on a metal–organic framework
Creators: name: Abdel‐Mageed, Ali M.
name: Rungtaweevoranit, Bunyarat
name: Impeng, Sarawoot
name: Bansmann, Joachim
name: Rabeah, Jabor
name: Chen, Shilong
name: Häring, Thomas
name: Namuangrak, Supawadee
name: Faungnawakij, Kajornsak
name: Brückner, Angelika
name: Behm, R. Jürgen
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Density Functional Theory
subject: In Situ/Operando Spectroscopies
subject: Single-Atom Catalysts
subject: DDC 540 / Chemistry & allied sciences
subject: Metal-organic frameworks
subject: Reaction mechanisms (Chemistry)
subject: Catalysts
subject: Metallorganisches Netzwerk
subject: Reaktionsmechanismus

description: Elucidating the reaction mechanism in heterogeneous catalysis is critically important for catalyst development, yet remains challenging because of the often unclear nature of the active sites. Using a molecularly defined copper single-atom catalyst supported by a UiO-66 metal–organic framework (Cu/UiO-66) allows a detailed mechanistic elucidation of the CO oxidation reaction. Based on a combination of in situ/operando spectroscopies, kinetic measurements including kinetic isotope effects, and density-functional-theory-based calculations, we identified the active site, reaction intermediates, and transition states of the dominant reaction cycle as well as the changes in oxidation/spin state during reaction. The reaction involves the continuous reactive dissociation of adsorbed O2, by reaction of O2,ad with COad, leading to the formation of an O atom connecting the Cu center with a neighboring Zr4+ ion as the rate limiting step. This is removed in a second activated step.
Let’s Do It for Real: Making the Ecosystem Service Concept Operational in Regional Planning for Climate Change Adaptation
Creators: name: Longo, Alessandra
name: Zardo, Linda
name: Maragno, Denis
name: Musco, Francesco
name: Burkhard, Benjamin
Publisher: name: Basel : MDPI
Year: 2024
Subjects: subject: adaptive planning
subject: decision-support tools
subject: land cover analysis
subject: science-policy interface
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft::333 | Boden- und Energiewirtschaft::333,7 | Natürliche Ressourcen, Energie und Umwelt
subject: Dewey Decimal Classification::600 | Technik::690 | Hausbau, Bauhandwerk

description: The application of ecosystem service (ES) knowledge to planning processes and decision-making can lead to more effective climate change adaptation. Despite the increased attention given to the ES concept, its degree of integration and use in spatial planning processes are still below the expectations of those who are promoting this concept. Barriers hindering its operationalisation cover a span of aspects ranging from theoretical to procedural and methodological issues. Overall, there is a general lack of guidance on how and at what point ES knowledge should be integrated into planning processes. This study aims to promote the inclusion of ES knowledge into spatial planning practices and decision-making processes to enhance climate change adaptation. A replicable GIS-based methodology is proposed. First, the potential supply of ESs that can support climate change adaptation (ESCCAs) is defined, mapped, and quantified. Then, a need for an ESCCA supply is identified, and territorial capacities to respond to the expected climate change impacts on natural and socio-economic sectors are assessed. The methodology is applied to the Friuli Venezia Giulia Autonomous Region (Italy) as an illustrative case study. The results reveal that areas with similar geomorphological characteristics tend to respond similarly. Forest ecosystems, inland wetlands and specifically salt marshes can potentially supply a greater variety of ESCCAs. In the case study area, about 62% of the supplied ESCCAs can contribute to reducing the impacts in more than 50% of the impacted sectors. The territory of the study site generally shows good preparedness for expected impacts in most of the analysed sectors; less prepared areas are characterised by agricultural ecosystems. This reading approach based on land cover analyses can thus assist in developing policies to enhance different territorial capacities, ultimately leading to better and more sustainable decision-making.
Peatmass Change and Water Level Influencing Regenerated Melaleuca Forest after a Fire in U Minh Thuong National Park, Vietnam
Creators: name: Thai, Luom Thanh
name: Tran, Thang Van
name: Le, Khai Viet
name: Flörke Staats, Maja
Publisher: name: Basel : MDPI
Year: 2024
Subjects: subject: Melaleuca forest regeneration
subject: peat
subject: peat chemical
subject: peat water environment
subject: U Minh Thuong National Park
subject: Vietnam
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft::333 | Boden- und Energiewirtschaft::333,7 | Natürliche Ressourcen, Energie und Umwelt
subject: Dewey Decimal Classification::600 | Technik::690 | Hausbau, Bauhandwerk

description: Following the largest forest fire in Vietnam in 2002, various activities were undertaken to sustain the mangrove forest on peat soil remnants in the Mekong Delta region. These activities included promoting natural regeneration, afforestation, and rapid forest restoration measures, in addition to other protective measures such as rainwater retention to maintain moisture levels for fire prevention. However, two critical challenges emerged: allowing the forest to naturally regenerate would lead to annual forest fires but maintaining a constant water level through year-round water retention would harm biodiversity. The study was conducted in U Minh Thuong National Park to address forest regeneration. After a major forest fire in Vietnam, various measures were taken to promote forest regeneration, including afforestation, silvicultural solutions, and hydrological techniques such as rainwater storage to maintain humidity and prevent future fires. A hand drill was used to collect samples, and a total of 15 plots were set up to survey the growth of the forest at three peat thickness levels. At each of the three collection sites, samples of one kg were collected and labeled according to the site as UTM1, UTM2, and UTM3. The samples were then sent to the laboratory of the Southern Institute of Forestry Science for analysis. There was a relationship between the chemical indicators of peat and the evolution of the Melaleuca forest. Peat thickness and flooding regime significantly influenced the growth of the Melaleuca forest, while another identified relationship was between peat chemical indicators and forest growth. The chemical composition of peat water changed significantly due to the rainy and dry seasons, with nutrient content and pH affecting forest growth. Peat thickness and flooding regime were essential in regulating forest growth. These studies highlight the importance of considering multiple factors, such as peat thickness and chemical properties, when developing effective forest restoration strategies. By understanding the relationship between peat thickness, chemical properties, and forest growth, forest managers can develop targeted strategies to promote regeneration while minimizing negative impacts on biodiversity.
Making photocatalysis comparable using a modular and characterized open-source photoreactor
Creators: name: Kowalczyk, Daniel
name: Li, Pengcheng
name: Abbas, Amir
name: Eichhorn, Jonas
name: Buday, Philipp
name: Heiland, Magdalena
name: Pannwitz, Andrea
name: Schacher, Felix H.
name: Weigand, Wolfgang
name: Streb, Carsten
name: Ziegenbalg, Dirk
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: actinometry
subject: photoreactors
subject: DDC 540 / Chemistry & allied sciences
subject: Photocatalysis
subject: Radiometry
subject: Open Source
subject: Fotokatalyse
subject: Dosimetrie

description: Reproducibility and comparability of photocatalytic experiments are still challenging, owing to the large number of experimental parameters and their comprehensive documentation. To overcome this limitation, a modular, adaptable, and extensible photoreactor platform is reported, which enables experiments under well-characterized, reproducible conditions. Comparability is ensured by comprehensive photonic characterization with chemical actinometry, radiometry and open documentation of the incident photon fluxes in the reaction vessels for different setups as well as the homogeneity of irradiation in multi-reactor setups. Comprehensive documentation minimizes the need for repeated photonic characterization when modifying the setups. Experimental reproducibility within and across experiments was evaluated with studies of photocatalytic systems for hydrogen evolution, emphasizing the validity of the concept.
In vitro evaluation of the osteogenic and antimicrobial potential of porous wollastonite scaffolds impregnated with ethanolic extracts of propolis
Creators: name: Moreno Florez, Ana Isabel
name: Malagon, Sarita
name: Ocampo, Sebastian
name: Leal-Marin, Sara
name: Ossa, Edgar Alexander
name: Glasmacher, Birgit
name: Garcia, Claudia
name: Pelaez-Vargas, Alejandro
Publisher: name: Lausanne : Frontiers Media
Year: 2024
Subjects: subject: 3D printing
subject: antimicrobial activity
subject: bone tissue engineering
subject: human bone marrow stem cells
subject: wollastonite
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Context: The development of porous devices using materials modified with various natural agents has become a priority for bone healing processes in the oral and maxillofacial field. There must be a balance between the proliferation of eukaryotic and the inhibition of prokaryotic cells to achieve proper bone health. Infections might inhibit the formation of new alveolar bone during bone graft augmentation. Objective: This study aimed to evaluate the in vitro osteogenic behavior of human bone marrow stem cells and assess the antimicrobial response to 3D-printed porous scaffolds using propolis-modified wollastonite. Methodology: A fractional factorial design of experiments was used to obtain a 3D printing paste for developing scaffolds with a triply periodic minimal surface (TPMS) gyroid geometry based on wollastonite and modified with an ethanolic propolis extract. The antioxidant activity of the extracts was characterized using free radical scavenging methods (DPPH and ABTS). Cell proliferation and osteogenic potential using Human Bone Marrow Stem Cells (bmMSCs) were assessed at different culture time points up to 28 days. MIC and inhibition zones were studied from single strain cultures, and biofilm formation was evaluated on the scaffolds under co-culture conditions. The mechanical strength of the scaffolds was evaluated. Results: Through statistical design of experiments, a paste suitable for printing scaffolds with the desired geometry was obtained. Propolis extracts modifying the TPMS gyroid scaffolds showed favorable cell proliferation and metabolic activity with osteogenic potential after 21 days. Additionally, propolis exhibited antioxidant activity, which may be related to the antimicrobial effectiveness of the scaffolds against S. aureus and S. epidermidis cultures. The mechanical properties of the scaffolds were not affected by propolis impregnation. Conclusion: These results demonstrate that propolis-impregnated porous wollastonite scaffolds might have the potential to stimulate bone repair in maxillofacial tissue engineering applications.
Formative Ideas of the National University: A Thematic Analysis of Texts from the Long 19th Century
Creators: name: Bengson, Nex
Publisher: name: Basingstoke : Palgrave Macmillan
Year: 2024
Subjects: subject: Idea of the university
subject: Nationalism
subject: Organizational script
subject: State formation
subject: Textual analysis
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::370 | Erziehung, Schul- und Bildungswesen

description: For the most part, the concept of the “national university” possess significant overlaps with the public/state, civic, and flagship university. Toward enriching the conceptual toolkit of higher education, this study explores what has been meant by a 'national university' and how could we identify such an organization empirically. Through a thematic analysis of a digital corpus in English, the study identifies four substantive themes that characterize the national university as it was articulated during the formative period of the nation-state. The core themes of such a concept include functioning as a tool for state development in terms of human capital, cultural identity, and social networks; serving as a nation’s most advanced learning institution; providing meritocratic higher education without discrimination and in consideration of subnational divisions; and possessing a definite link with the central government. Comparing these findings with closely related organizational models in higher education, a key difference of the national university is in its role in articulating a national identity through providing advanced education that is particularly inclusive of subnational divisions. The paper further forwards two contrasting empirical approaches to the national university: a historical–legal de jure approach and a sociocultural de facto approach.
Evaluation of 1H-NMR spectroscopy-based quantification methods of the supramolecular aggregation of a molecular photosensitizer
Creators: name: Pehlken, Christian
name: Pfeffer, Michael G.
name: Reich, Katharina
name: Rau, Sven
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: SELF-ASSOCIATION
subject: PI-STACKING
subject: RUTHENIUM(II) COMPLEXES
subject: DIMERIZATION CONSTANTS
subject: OSMIUM(II) COMPLEXES
subject: HYDROGEN-PRODUCTION
subject: ELECTRON-TRANSFER
subject: RU(II) COMPLEXES
subject: DNA-BINDING
subject: DDC 540 / Chemistry & allied sciences
subject: Ruthenium Isotopes
subject: Osmium Isotopes
subject: Magnetic resonance
subject: Charge exchange
subject: DNA-binding proteins
subject: DNS-Bindungsproteine

description: The supramolecular dimerization of a ruthenium polypyridyl precursor of a well-developed family of hydrogen-evolving photocatalysts via π–π interactions of the polyheteroaromatic bridging ligand was quantified with concentration-dependent 1H-NMR spectroscopy. The data sets were analyzed with different calculation and fit methods. A comparison between the results of direct calculation and linear and nonlinear approaches showed that the application of a global nonlinear fit procedure yields the best results. The presented methods are also applicable for dimerization processes in the solution of other molecular moieties.
Exploring Data Mining in Chemistry Education: Building a Web-Based Learning Platform for Learning Analytics
Creators: name: Roski, Marvin
name: Ewerth, Ralph
name: Hoppe, Anett
name: Nehring, Andreas
Publisher: name: Washington, DC : ACS Publications
Year: 2024
Subjects: subject: Internet/Web-Based Learning
subject: Ionic Bonding
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::370 | Erziehung, Schul- und Bildungswesen
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: The integration of learning analytics and artificial intelligence methods into education is part of the latest developments and significantly affects chemistry education (research): researchers might face the challenge of collecting and analyzing content-rich data sets involving interdisciplinary approaches from computer science, chemistry, and chemistry education. Developing a learning platform offers a higher degree of freedom compared to using existing Learning Management Systems. This paper presents a step-by-step overview of how we designed and created the web-based learning platform “I3Learn”. This concrete example showcases how the content management system WordPress can be utilized to develop an online learning infrastructure that enables the application of learning analytics methods. Our approach allows collection of time-accurate log files concerning individual usage behaviors without programming skills. The step-by-step overview enables chemistry education researchers to set up a customized web-based learning platform and lay the data foundation for learning analytics. The value of the I3Learn platform is shown through a compelling use-case scenario involving 580 9th- and 10th-grade learners in German chemistry classrooms. In this scenario, we collected and analyzed half a million log files, and we report exemplary results and insights from the data.
31 days of COVID-19—cardiac events during restriction of public life—a comparative study
Creators: name: Rattka, Manuel
name: Baumhardt, Michael
name: Dreyhaupt, Jens
name: Rothenbacher, Dietrich
name: Thiessen, Kevin
name: Markovic, Sinisa
name: Rottbauer, Wolfgang
name: Imhof, Armin
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: COVID-19
subject: Cardiac events
subject: Acute coronary syndrome
subject: Epidemiology
subject: DDC 610 / Medicine & health

description: Abstract Aims The coronavirus SARS-CoV-2 outbreak led to the most recent pandemic of the twenty-first century. To contain spread of the virus, many nations introduced a public lockdown. How the pandemic itself and measures of social restriction affect hospital admissions due to acute cardiac events has rarely been evaluated yet. Methods and Results German public authorities announced measures of social restriction between March 21st and April 20th, 2020. During this period, all patients suffering from an acute cardiac event admitted to our hospital (N = 94) were assessed and incidence rate ratios (IRR) of admissions for acute cardiac events estimated, and compared with those during the same period in the previous three years (2017–2019, N = 361). Admissions due to cardiac events were reduced by 22% as compared to the previous years (n = 94 vs. an average of n = 120 per year for 2017–2019). Whereas IRR for STEMI 1.20 (95% CI 0.67–2.14) and out-of-hospital cardiac arrest IRR 0.82 (95% CI 0.33–2.02) remained similar, overall admissions with an IRR of 0.78 (95% CI 0.62–0.98) and IRR for NSTEMI with 0.46 (95% CI 0.27–0.78) were significantly lower. In STEMI patients, plasma concentrations of high-sensitivity troponin T at admission were significantly higher (644 ng/l, IQR 372–2388) compared to 2017–2019 (195 ng/l, IQR 84–1134; p = 0.02). Conclusion The SARS-CoV-2 pandemic and concomitant social restrictions are associated with reduced cardiac events admissions to our tertiary care center. From a public health perspective, strategies have to be developed to assure patients are seeking and getting medical care and treatment in time during SARS-CoV-2 pandemic.
The Roman Fort at Bewcastle: an Analytical Field Survey.
Creators: name: Sainsbury, Iain
name: Welfare, Humphrey G
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 90, 139-146
description: Survey was done for management purposes of the 2.4ha hexagonal fort, much destroyed and obscured. More details of the interior are needed and the vicus should be identified. Re-use of the site in 8th century (cross), in med times (church, market, castle) and in Border raiding shows its strategic siting.
ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways - lessons from breast cancer patients
Creators: name: Sachsenweger, Juliane
name: Jansche, Rebecca
name: Merk, Tatjana
name: Heitmeir, Benedikt
name: Deniz, Miriam
name: Faust, Ulrike
name: Roggia, Cristiana
name: Tzschach, Andreas
name: Schroeder, Christopher Maximilian
name: Riess, Angelika
name: Pospiech, Helmut
name: Peltoketo, Hellevi
name: Pylkäs, Katri
name: Winqvist, Robert
name: Wiesmüller, Lisa
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Double-strand breaks
subject: Targets BRCA1
subject: MRN complex
subject: RAP80
subject: DDC 610 / Medicine & health
subject: Breast; Cancer
subject: Breast neoplasms
subject: Cell cycle
subject: DNA
subject: Proteins
subject: DNA breaks, Double-stranded
subject: DNA repair
subject: Genes, BRCA1
subject: Brustkrebs
subject: DNS-Schädigung
subject: DNS-Reparatur
subject: Gen BRCA 1
subject: Zellzyklus
subject: Proteine

description: It has been well-established that mutations in BRCA1 and BRCA2, compromising functions in DNA double-strand break repair (DSBR), confer hereditary breast and ovarian cancer risk. Importantly, mutations in these genes explain only a minor fraction of the hereditary risk and of the subset of DSBR deficient tumors. Our screening efforts identified two truncating germline mutations in the gene encoding the BRCA1 complex partner ABRAXAS1 in German early-onset breast cancer patients. To unravel the molecular mechanisms triggering carcinogenesis in these carriers of heterozygous mutations, we examined DSBR functions in patient-derived lymphoblastoid cells (LCLs) and in genetically manipulated mammary epithelial cells. By use of these strategies we were able to demonstrate that these truncating ABRAXAS1 mutations exerted dominant effects on BRCA1 functions. Interestingly, we did not observe haploinsufficiency regarding homologous recombination (HR) proficiency (reporter assay, RAD51-foci, PARP-inhibitor sensitivity) in mutation carriers. However, the balance was shifted to use of mutagenic DSBR-pathways. The dominant effect of truncated ABRAXAS1 devoid of the C-terminal BRCA1 binding site can be explained by retention of the N-terminal interaction sites for other BRCA1-A complex partners like RAP80. In this case BRCA1 was channeled from the BRCA1-A to the BRCA1-C complex, which induced single-strand annealing (SSA). Further truncation, additionally deleting the coiled-coil region of ABRAXAS1, unleashed excessive DNA damage responses (DDRs) de-repressing multiple DSBR-pathways including SSA and non-homologous end-joining (NHEJ). Our data reveal de-repression of low-fidelity repair activities as a common feature of cells from patients with heterozygous mutations in genes encoding BRCA1 and its complex partners.
Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors
Creators: name: Wolf, Christine
name: Maus, Carsten
name: Persicke, Michael R.O.
name: Filarsky, Katharina
name: Tausch, Eugen
name: Schneider, Christof
name: Döhner, Hartmut
name: Stilgenbauer, Stephan
name: Lichter, Peter
name: Höfer, Thomas
name: Mertens, Daniel
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: BCR signaling
subject: CLL
subject: ibrutinib
subject: modeling
subject: DDC 610 / Medicine & health
subject: Receptors, Antigen, B-Cell; Metabolism
subject: Signal transduction
subject: Leukemia, Lymphoid; Drug therapy
subject: Protein-tyrosine kinases; Antagonists and inhibitors
subject: Chronisch-lymphatische Leukämie
subject: B-Lymphozyten-Rezeptor
subject: Rezeptor-Tyrosinkinasen
subject: Signaltransduktion

description: B-cell receptor (BCR) signaling is central for the pathomechanism of chronic lymphocytic leukemia (CLL), and inhibitors of BCR signaling have substantially improved treatment options. To model malignant and nonmalignant BCR signaling, we quantified five components of BCR signaling (ZAP70/SYK, BTK, PLCγ2, AKT, ERK1/2) in single cells from primary human leukemic cells and from nonmalignant tissue. We measured signaling activity in a time-resolved manner after stimulation with BCR crosslinking by anti-IgM and/or anti-CD19 and with or without inhibition of phosphatases with H2O2. The phosphorylation of BCR signaling components was increased in malignant cells compared to nonmalignant cells and in IGHV unmutated CLL cells compared to IGHV mutated CLL cells. Intriguingly, inhibition of phosphatases with H2O2 led to higher phosphorylation levels of BCR components in CLL cells with mutated IGHV compared to unmutated IGHV. We modeled the connectivity of the cascade components by correlating signal intensities across single cells. The network topology remained stable between malignant and nonmalignant cells. To additionally test for the impact of therapeutic compounds on the network topology, we challenged the BCR signaling cascade with inhibitors for BTK (ibrutinib), PI3K (idelalisib), LYN (dasatinib) and SYK (entospletinib). Idelalisib treatment resulted in similar effects in malignant and nonmalignant cells, whereas ibrutinib was mostly active on CLL cells. Idelalisib and ibrutinib had complementary effects on the BCR signaling cascade whose activity was further reduced upon dasatinib and entospletinib treatment. The characterization of the molecular circuitry of leukemic BCR signaling will allow a more refined targeting of this Achilles heel.
A framework to characterise operational daylighting performance in classrooms: measurement, observation and user perspectives
Creators: name: Drosou, Nafsika
Publisher: name: Loughborough University
Year: 2022
Subjects: subject: 129999 Built Environment and Design not elsewhere classified
subject: FOS: Civil engineering

description: Research confirms that daylight is important not only for vision, but also for general well-being. Little is known, however, about how real world occupied spaces perform in terms of daylight. This holds true particularly in schools, where practicalities prevent the collection of data from classrooms in use.The framework presented here addresses the lack of daylighting performance evidence from the real world, necessary for guiding daylighting predictions for classroom design. It describes and prototypes a methodology that achieves long-term daylighting performance monitoring in classrooms in use. This methodology also enables the observation of actions the occupants take to sustain or improve their visual comfort.Four UK secondary school classrooms were used as case studies and were monitored for up to a year. A mixed method approach was taken in order to associate measured luminance, a physical characteristic of light, to user interaction with electric lights and blinds, as well as student subjective responses.This resulted in two novel fine-grained year-long datasets, as well as a record of student appraisals of the luminous environment. The luminance dataset contains over a trillion measurements captured on-site simultaneously for multiple (nearly 18,000,000) points in space, at a 10-minute frequency over a year, resulting in multiple (over 62,000) points in time.Application of the long-term monitoring method was found to be robust and useful for monitoring complex multi-user spaces for at least six consecutive months. Combining fine-grained luminance mapping, records of occupant interactions with design elements and occupant subjective views of the case study classrooms provided a better understanding of the many factors that shape operational daylighting performance. This was achieved by identifying specific parameters, examining their effect across a set of the three types of evidence and highlighting the complex relationships detected between them.The three aspect framework presented here contributes to a philosophy of research that addresses real world challenges by combining their technical, behavioural and subjective expressions. In doing so it supports the view that sustainable and thus effective solutions are those that stem from holistic people-centred interdisciplinary research.
Quantifying species contributions to ecosystem process: a global assessment of functional trait and phylogenetic metrics across avian seed-dispersal networks
Creators: name: Pigot, Alexander L.
name: Bregman, Tom
name: Sheard, Catherine
name: Daly, Benjamin
name: Rampal S. Etienne
name: Tobias, Joseph A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Quantifying the role of biodiversity in ecosystems not only requires understanding the links between species and the ecological functions and services they provide, but also how these factors relate to measurable indices, such as functional traits and phylogenetic diversity. However, these relationships remain poorly understood, especially for heterotrophic organisms within complex ecological networks. Here, we assemble data on avian traits across a global sample of mutualistic plant-frugivore networks to critically assess how the functional roles of frugivores are associated with their intrinsic traits, as well as their evolutionary and functional distinctiveness. We find strong evidence for niche complementarity, with phenotypically and phylogenetically distinct birds interacting with more unique sets of plants. However, interaction strengths - the number of plant species dependent on a frugivore - were unrelated to evolutionary or functional distinctiveness, largely because distinct frugivores tend to be locally rare, and thus have fewer connections across the network. Instead, interaction strengths were better predicted by intrinsic traits, including body size, gape width and dietary specialization. Our analysis provides general support for the utility of traits in quantifying species ecological functions, but also highlights the need to go beyond simple metrics of functional or phylogenetic diversity to consider the multiple pathways through which traits may determine ecological processes.
Health-economic evaluation of collaborative orthogeriatric care for patients with a hip fracture in Germany: a retrospective cohort study using health and long-term care insurance claims data
Creators: name: Schulz, Claudia
name: Büchele, Gisela
name: Peter, Raphael S.
name: Rothenbacher, Dietrich
name: Brettschneider, Christian
name: Liener, Ulrich C.
name: Becker, Clemens
name: Rapp, Kilian
name: König, Hans-Helmut
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Orthogeriatric co-management
subject: Economic evaluation
subject: Cost-effectiveness
subject: Entropy balancing
subject: DDC 330 / Economics
subject: DDC 610 / Medicine & health

description: Abstract Background Evidence suggests benefits of orthogeriatric co-management (OGCM) for hip fracture patients. Yet, evidence on cost-effectiveness is limited and based on small datasets. The aim of our study was to conduct an economic evaluation of the German OGCM for geriatric hip fracture patients. Methods This retrospective cohort study was based on German health and long-term care insurance data. Individuals were 80 years and older, sustained a hip fracture in 2014, and were treated in hospitals providing OGCM (OGCM group) or standard care (control group). Health care costs from payer and societal perspective, life years gained (LYG) and cost-effectiveness were investigated within 1 year. We applied weighted gamma and two-part models, and entropy balancing to account for the lack of randomisation. We calculated incremental cost-effectiveness ratios (ICER) and employed the net-benefit approach to construct cost-effectiveness acceptability curves. Results 14,005 patients were treated in OGCM, and 10,512 in standard care hospitals. Total average health care costs per patient were higher in the OGCM group: €1181.53 (p < 0.001) from payer perspective, and €1408.21 (p < 0.001) from societal perspective. The ICER equalled €52,378.12/ LYG from payer and €75,703.44/ LYG from societal perspective. The probability for cost-effectiveness would be 95% if the willingness-to-pay was higher than €82,000/ LYG from payer, and €95,000/ LYG from societal perspective. Conclusion Survival improved in hospitals providing OGCM. Costs were found to increase, driven by inpatient and long-term care. The cost-effectiveness depends on the willingness-to-pay. The ICER is likely to improve with a longer follow-up.
Comparative evaluation of light-driven catalysis : a framework for standardized reporting of data
Creators: name: Ziegenbalg, Dirk
name: Pannwitz, Andrea
name: Rau, Sven
name: Dietzek-Ivanšić, Benjamin
name: Streb, Carsten
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Comparability
subject: Heterogeneous
subject: Homogeneous
subject: Light-Driven Catalysis
subject: DDC 540 / Chemistry & allied sciences
subject: Photocatalysis
subject: Fotokatalyse

description: Light-driven homogeneous and heterogeneous catalysis require a complex interplay between light absorption, charge separation, charge transfer, and catalytic turnover. Optical and irradiation parameters as well as reaction engineering aspects play major roles in controlling catalytic performance. This multitude of factors makes it difficult to objectively compare light-driven catalysts and provide an unbiased performance assessment. This Scientific Perspective highlights the importance of collecting and reporting experimental data in homogeneous and heterogeneous light-driven catalysis. A critical analysis of the benefits and limitations of the commonly used experimental indicators is provided. Data collection and reporting according to FAIR principles is discussed in the context of future automated data analysis. The authors propose a minimum dataset as a basis for unified collecting and reporting of experimental data in homogeneous and heterogeneous light-driven catalysis. The community is encouraged to support the future development of this parameter list through an open online repository.
yolo_embryo_detection.h5
Creators: name: Yu, Lu
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460306
subject: Image processing
classificationCode: 460304
subject: Computer vision
classificationCode: 460309
subject: Video processing

description: Finetuned yolov3 model (keras) to detect blastocysts from noisy backgrounds
title: OFROM: interview avec unine15a50m
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.dbb23104.v2#ef0efd0d696aa007c7ec2ac7951be0ced496d953
Soft Sensor for Solidification Process in Steel Billet Casting [CSS2]
Creators: name: Schlautmann, Martin
name: Nölle, Christoph
Publisher: name: Zenodo
Year: 2022
Subjects: steel
Continuous Casting
Automation
Process Industry
Solidification
Industry 4.0
Innovation
H2020

description: Continuous casting of billets is an important step in the steel production. It takes place after the primary and secondary steelmaking processes, which produce batches of liquid steel either in a blast furnace and basic oxygen furnace or an electric arc furnace with subsequent ladle treatment steps, and before the downstream treatment of the solid semi products in a rolling mill. In the casting machine, liquid steel at a temperature of about 50 K above liquidus temperature is first poured into the so-called tundish, from where it flows through a submerged entry nozzle into the mould. There, by means of water cooling the steel is cooled down so that the outer shell of the strand starts to solidify. When the steel leaves the bottom of the mould this shell must be thick enough to support the liquid core that is still present at that time. When the strand has become fully solid, it is cut into pieces of approximately 10 meters length, the so-called billets. Improper cooling conditions can cause thermal stresses leading to surface or internal cracks. It is not possible, however, to directly measure the temperature field within the solidifying strand, which makes it hard to select the correct casting parameters for each of the different steel grades produced, and to evaluate the impact of the parameters on the final product quality.
description: https://www.capri-project.com
Supplementary methods from Improved homeothermy and hypothermia in African lions during gestation
Creators: name: Trethowan, Paul D.
name: Hart, Tom
name: Loveridge, Andrew J.
name: Haw, Anna
name: Fuller, Andrea
name: Macdonald, David W.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Further study particulars
Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
Creators: name: Pruss, Maximilian
name: Dwucet, Annika
name: Tanriover, Mine
name: Hlavac, Michal
name: Kast, Richard Eric
name: Debatin, Klaus-Michael
name: Wirtz, Christian Rainer
name: Halatsch, Marc-Eric
name: Siegelin, Markus David
name: Westhoff, Mike-Andrew
name: Karpel-Massler, Georg
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: CNS cancer
subject: DDC 610 / Medicine & health
subject: Cancer
subject: Central nervous system; Cancer
subject: Neoplasms; Drug therapy
subject: Glioblastoma; Drug therapy
subject: Krebs
subject: Glioblastom
subject: Pharmakotherapie

description: Background Dysregulation of the metabolome is a hallmark of primary brain malignancies. In this work we examined whether metabolic reprogramming through a multi-targeting approach causes enhanced anti-cancer activity in glioblastoma. Methods Preclinical testing of a combined treatment with ONC201/TIC10 and 2-Deoxyglucose was performed in established and primary-cultured glioblastoma cells. Extracellular flux analysis was used to determine real-time effects on OXPHOS and glycolysis. Respiratory chain complexes were analysed by western blotting. Biological effects on tumour formation were tested on the chorioallantoic membrane (CAM). Results ONC201/TIC10 impairs mitochondrial respiration accompanied by an increase of glycolysis. When combined with 2-Deoxyglucose, ONC201/TIC10 induces a state of energy depletion as outlined by a significant decrease in ATP levels and a hypo-phosphorylative state. As a result, synergistic anti-proliferative and anti-migratory effects were observed among a broad panel of different glioblastoma cells. In addition, this combinatorial approach significantly impaired tumour formation on the CAM. Conclusion Treatment with ONC201/TIC10 and 2-Deoxyglucose results in a dual metabolic reprogramming of glioblastoma cells resulting in a synergistic anti-neoplastic activity. Given, that both agents penetrate the blood–brain barrier and have been used in clinical trials with a good safety profile warrants further clinical evaluation of this therapeutic strategy.
title: OFROM: interview avec unine15a49d
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.afa134ch.v2#782aaaccedd583b4ccf115b8d6129d00f4d0342b
Supplementary Figure 1 from Bacteria facilitate prey retention by the pitcher plant Darlingtonia californica
Creators: name: Armitage, David W.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Photograph of water droplet suspended from pendant-drop tensiometer.
Production of propionate using metabolically engineered strains of Clostridium saccharoperbutylacetonicum
Creators: name: Baur, Tina
name: Wentzel, Alexander
name: Dürre, Peter
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Clostridium saccharoperbutylacetonicum
subject: Propionate production
subject: Acrylate pathway
subject: Fluorescence-activating and absorption-shifting tag
subject: Promoter activities
subject: Two-plasmid system
subject: DDC 570 / Life sciences
subject: Acrylates
subject: Promoters
subject: Fluoreszenz

description: The carboxylic acid propionate is a valuable platform chemical with applications in various fields. The biological production of this acid has become of great interest as it can be considered a sustainable alternative to petrochemical synthesis. In this work, Clostridium saccharoperbutylacetonicum was metabolically engineered to produce propionate via the acrylate pathway. In total, the established synthetic pathway comprised eight genes encoding the enzymes catalyzing the conversion of pyruvate to propionate. These included the propionate CoA-transferase, the lactoyl-CoA dehydratase, and the acryloyl-CoA reductase from Anaerotignum neopropionicum as well as a D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. mesenteroides. Due to difficulties in assembling all genes on one plasmid under the control of standard promoters, the PtcdB-tcdR promoter system from Clostridium difficile was integrated into a two-plasmid system carrying the acrylate pathway genes. Several promoters were analyzed for their activity in C. saccharoperbutylacetonicum using the fluorescence-activating and absorption-shifting tag (FAST) as a fluorescent reporter to identify suitable candidates to drive tcdR expression. After selecting the lactose-inducible PbgaL promoter, engineered C. saccharoperbutylacetonicum strains produced 0.7 mM propionate upon induction of gene expression. The low productivity was suspected to be a consequence of a metabolic imbalance leading to acryloyl-CoA accumulation in the cells. To even out the proposed imbalance, the propionate-synthesis operons were rearranged, thereby increasing the propionate concentration by almost four-fold. This study is the first one to report recombinant propionate production using a clostridial host strain that has opened a new path towards bio-based propionate to be improved further in subsequent work. Key points • Determination of promoter activities in C. saccharoperbutylacetonicum using FAST. • Implementation of propionate production in C. saccharoperbutylacetonicum. • Elevation of propionate production by 375% to a concentration of 3 mM.
title: Ð¢ÑÑÐµÑÐºÐ¸Ð¹ ÑÐ·ÑÐº: ÐÐ°Ð·Ð¾Ð²ÑÐ¹ ÐºÑÑÑ. Ð£ÑÐ¾Ð²ÐµÐ½Ñ Ð1
title: ÑÐ°Ð±Ð¾ÑÐ°Ñ ÑÐµÑÑÐ°Ð´Ñ
titleType: Subtitle
Creators: name: Ð¢ÑÐ°Ð½Ð°, ÐÑÑÑÐ°ÑÐ°
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2023
Subjects: ÑÑÑÐµÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

description: Ð Ð°Ð±Ð¾ÑÐ°Ñ ÑÐµÑÑÐ°Ð´Ñ Ð¿Ð¾ Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÐºÐµ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ¾ÑÑÐ°Ð²Ð½Ð¾Ð¹ ÑÐ°ÑÑÑÑ ÑÑÐµÐ±Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Â«Ð¢ÑÑÐµÑÐºÐ¸Ð¹ ÑÐ·ÑÐº. ÐÐ°Ð·Ð¾Ð²ÑÐ¹ ÐºÑÑÑ. Ð£ÑÐ¾Ð²ÐµÐ½Ñ Ð1Â». ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ Ð²ÐºÐ»ÑÑÐ°ÐµÑ Ð² ÑÐµÐ±Ñ 8 ÑÐµÐ¼, Ð² ÐºÐ¾ÑÐ¾ÑÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð¹ Ð»ÐµÐºÑÐ¸ÐºÐ¾-Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð», ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ð¹ ÑÑÐ¾Ð²Ð½Ñ Ð²Ð»Ð°Ð´ÐµÐ½Ð¸Ñ Ð1 ÑÐ¾Ð³Ð»Ð°ÑÐ½Ð¾ Ð¾Ð±ÑÐµÐ¿ÑÐ¸Ð½ÑÑÐ¾Ð¹ ÐÐ²ÑÐ¾Ð¿ÐµÐ¹ÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ ÑÑÐ¾Ð²Ð½ÐµÐ¹ Ð²Ð»Ð°Ð´ÐµÐ½Ð¸Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½ÑÐ¼ ÑÐ·ÑÐºÐ¾Ð¼. Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¾ Ð½Ð° Ð·Ð°Ð½ÑÑÐ¸ÑÑ Ð¿Ð¾ ÑÑÑÐµÑÐºÐ¾Ð¼Ñ ÑÐ·ÑÐºÑ ÐºÐ°Ðº Ð¿Ð¾Ð´ ÑÑÐºÐ¾Ð²Ð¾Ð´ÑÑÐ²Ð¾Ð¼ Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°ÑÐµÐ»Ñ, ÑÐ°Ðº Ð¸ Ð´Ð»Ñ ÑÐ°Ð¼Ð¾ÑÑÐ¾ÑÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð². ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð², Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ Ð¿Ð¾ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÐ¸ Â«ÐÐ°ÑÑÐ±ÐµÐ¶Ð½Ð¾Ðµ ÑÐµÐ³Ð¸Ð¾Ð½Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸ÐµÂ» Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Â«Ð¡ÑÑÐ°Ð½Ñ ÐÐ»Ð¸Ð¶Ð½ÐµÐ³Ð¾ ÐÐ¾ÑÑÐ¾ÐºÐ°: Ð¢ÑÑÑÐ¸ÑÂ».
Design review
Creators: name: Brunner, Olivier
name: Syratchev, Igor
name: Batto, Guillaume
Publisher: name: Zenodo
Year: 2022

description: The objective of this work package is to design and build an industrial prototype of the LHC klystron -TH2167- klystron reaching 70% efficiency in collaboration with THALES. This report describes the status, the progress made and the next steps.
description: {"references": ["I.FAST MS55"]}
Information asymmetry and gendered behavior in organizations and digital markets
Creators: name: Spiess Bru, Clarissa Laura Maria
Publisher: name: Universität Paderborn
Year: 2023

description: Gegenstand der vorliegenden Dissertation ist die Analyse von Informationsasymmetrien am Beispiel digitaler Märkte und Erfahrungs- und Vertrauensgüter. Verortet in der Informationsökonomik, setzt sich die kumulative Dissertation mithilfe vier Projekte zum Ziel, neue Einsichten in den potenziellen Abbau von Informationsasymmetrien zwischen Produzenten und Verbraucher durch die dezidierte Analyse von Qualitätssignalen wie Reputation und Marktpreise zu generieren. So werden der Einfluss linguistischer Kategorien auf Marktpreise und professionelle Bewertungen mithilfe eines linguistisch-ökonometrischen Ansatzes skizziert (erstes Projekt), die dynamische Beziehung von Qualitätssignalen herausgestellt (zweites Projekt), sowie geschlechterspezifisches Verhalten und (unbewusste) Präferenzen am Beispiel professioneller Bewertungen untersucht (drittes und viertes Projekt). Basierend auf den empirischen Ergebnissen werden strategische Handlungsimplikationen für Marktteilnehmer der untersuchten Industrie formuliert.