cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of Novel Functionally Selective  -Opioid Receptor Scaffolds
Creators: name: Roth, B. L.
name: Kenakin, T.
name: White, K. L.
name: Bikbulatov, R. V.
name: Polepally, P. R.
name: Scopton, A. P.
name: Javitch, J. A.
name: Zjawiony, J. K.
name: Brown, P. J.
name: Rives, M.-L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The κ-opioid receptor (KOR)-dynorphin system has been implicated in the control of affect, cognition, and motivation, and is thought to be dysregulated in mood and psychotic disorders, as well as in various phases of opioid dependence. KOR agonists exhibit analgesic effects, although the adverse effects produced by some KOR agonists, including sedation, dysphoria, and hallucinations, have limited their clinical use. Interestingly, KOR-mediated dysphoria, assessed in rodents as aversion, has recently been attributed to the activation of the p38 mitogen-activated protein kinase pathway following arrestin recruitment to the activated KOR. Therefore, KOR-selective G protein–biased agonists, which do not recruit arrestin, have been proposed to be more effective analgesics, without the adverse effects triggered by the arrestin pathway. As an initial step toward identifying novel biased KOR agonists, we applied a multifaceted screening strategy utilizing both in silico and parallel screening approaches. We identified several KOR-selective ligand scaffolds with a range of signaling bias in vitro. The arylacetamide-based scaffold includes both G protein– and β-arrestin–biased ligands, while the endogenous peptides and the diterpene scaffolds are G protein biased. Interestingly, we found scaffold screening to be more successful than library screening in identifying biased ligands. Many of the identified functionally selective ligands are potent selective KOR agonists that are reported to be active in the central nervous system. They therefore represent excellent candidates for in vivo studies aiming at determining the behavioral effects mediated by specific KOR-mediated signaling cascades.
The development of dragonfly larvae (Odonata: Anisoptera) from two streams in north-eastern Victoria, Australia
Creators: name: Hawking, John H
name: New, Timothy R
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Developmental stages of larvae of eight species of Anisoptera from the Kiewa River and Middle Creek, Victoria, were determined and their phenology investigated. The last six to nine instars of each species were distinguished by size frequency and scatter plots, using labium width, metafemur and wing-pad measurements, and the early instars were estimated from Dyar's Law. This suggested between 11 to 14 instars. Four species appeared to be univoltine and four species semivoltine.
Lysine 48-Linked Polyubiquitination of Organic Anion Transporter-1 Is Essential for Its Protein Kinase C-Regulated Endocytosis
Creators: name: Patterson, C.
name: You, G.
name: Zhang, Q.
name: Li, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Organic anion transporter-1 (OAT1) mediates the body’s disposition of a diverse array of environmental toxins and clinically important drugs. Therefore, understanding the regulation of this transporter has profound clinical significance. We had previously established that OAT1 undergoes constitutive internalization from and recycling back to the cell surface and that acute activation of protein kinase C (PKC) inhibits OAT1 activity by reducing OAT1 cell-surface expression through accelerating its internalization from cell surface to intracellular compartments. However, the underlying mechanisms are poorly understood. In the current study, we provide novel evidence that acute activation of PKC significantly enhances OAT1 ubiquitination both in vitro and ex vivo. We further show that ubiquitination of cell-surface OAT1 increases in cells transfected with dominant negative mutant of dynamin-2, a maneuver blocking OAT1 internalization, which suggests that OAT1 ubiquitination proceeds before OAT1 internalization. Mass spectroscopy has revealed that ubiquitination of OAT1 consists of polyubiquitin chains, primarily through lysine 48 linkage. Transfection of cells with the dominant negative mutant of ubiquitin Ub-K48R, which prevents the formation of Lys48-linked polyubiquitin chains, abolishes PKC-stimulated OAT1 ubiquitination and internalization. Together, our findings demonstrate for the first time that Lys48-linked polyubiquitination is essential for PKC-regulated OAT1 trafficking.
Beyond mean-field study of a binary bosonic mixture in a state-dependent honeycomb lattice
Creators: name: Cao, Lushuai
name: Krönke, Sven
name: Stockhofe, Jan
name: Schmelcher, Peter
name: Simonet, Juliette
name: Sengstock, Klaus
name: Lühmann, Dirk-Sören
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate a binary mixture of bosonic atoms loaded into a state-dependent honeycomb lattice. For this system, the emergence of a so-called twisted-superfluid ground state was experimentally observed in [Soltan-Panahi et al., Nat. Phys. 8, 71 (2012)]. Theoretically, the origin of this effect is not understood. We perform numerical simulations of an extended Bose-Hubbard model adapted to the experimental parameters employing the Multi-Layer Multi-Configuration Time-Dependent Hartree method for Bosons. Our results confirm the overall applicability of mean-field theory within the relevant parameter range. Beyond this, we provide a detailed analysis of correlation effects correcting the mean-field result. These have the potential to induce asymmetries in single shot time-of-flight measurements, but we find no indication of the patterns characteristic of the twisted superfluid. We comment on the restrictions of our model and possible extensions.
Depression Genetics
Creators: name: Sbarra, David
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: This preregistration includes a series of confirmatory hypotheses seeking to (a) conduct, using data from the Wisconsin Longitudinal Study, a conceptual replication of between-family analyses linking a polygenic risk score for depressive symptoms and later subjective reports of depressive symptoms through four social determinant mediator variables; and, (b) specify a series of within-family (sibling-difference) models that can be used to examine whether the X-M associations of interest are consistent with a causal influence from the genetics of depressive symptom risk to different social experiences/exposures.
The effects of disturbance on a herbivore-epilithon interaction in an upland stream
Creators: name: Gawne, Benjamin
name: Lake, P. S
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Two experiments were performed in an upland stream to determine the effects of the frequency of physical disturbance on the relationship between an abundant glossosomatid trichopteran (Agapetus monticolus; Banks) and the epilithon upon which it feeds. Artificial cobbles with an established epilithic community were tumbled either every 1, 2 or 4 weeks. The first experiment failed to detect any significant effects of rock tumbling on the abundance of A. monticolus or the epilithon: a result due to several spates. The first experiment did reveal that disturbances may disrupt the ability of A. monticolus to locate patches of abundant food. The second experiment found that although the abundance of A. monticolus was not affected by the disturbances, periphyton abundance was significantly reduced. Increasing the frequency of disturbance did not magnify this effect. Comparisons of these results with other studies of disturbance in streams indicate that the effects of disturbance on herbivory may be highly variable. A variety of factors, such as the relative resistances of the herbivores and the epilithon, need to be examined before the effects of disturbances on lotic herbivorous interactions can be completely understood.
The TESS Triple-9 Catalog II: a new set of 999 uniformly-vetted exoplanet candidates
Creators: name: Magliano, Christian
name: Kostov, Veselin
name: Cacciapuoti, Luca
name: Covone, Giovanni
name: Inno, Laura
name: Fiscale, Stefano
name: Kuchner, Marc
name: Quintana, Elisa V.
name: Salik, Ryan
name: Saggese, Vito
name: Yablonsky, John M.
name: Fornear, Aline U.
name: Hyogo, Michiharu
name: Di Fraia, Marco Z.
name: Luca, Hugo A. Durantini
name: de Lambilly, Julien S.
name: Oliva, Fabrizio
name: Pagano, Isabella
name: Ienco, Riccardo M.
name: de Lima, Lucas T.
name: Andrés-Carcasona, Marc
name: Gallo, Francesco
name: Acharya, Sovan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Transiting Exoplanet Survey Satellite (TESS) mission is providing the scientific community with millions of light curves of stars spread across the whole sky. Since 2018 the telescope has detected thousands of planet candidates that need to be meticulously scrutinized before being considered amenable targets for follow-up programs. We present the second catalog of the Plant Patrol citizen science project containing 999 uniformly-vetted exoplanet candidates within the TESS ExoFOP archive. The catalog was produced by fully exploiting the power of the Citizen Science Planet Patrol project. We vetted TESS Objects of Interest (TOIs) based on the results of Discovery And Vetting of Exoplanets DAVE pipeline. We also implemented the Automatic Disposition Generator, a custom procedure aimed at generating the final classification for each TOI that was vetted by at least three vetters. The majority of the candidates in our catalog, $752$ TOIs, passed the vetting process and were labelled as planet candidates. We ruled out $142$ candidates as false positives and flagged $105$ as potential false positives. Our final dispositions and comments for all the planet candidates are provided as a publicly available supplementary table.
description: 17 pages, 11 figures, 5 tables. Accepted for publication on MNRAS
Molecular Insights into Microbial  -Glucuronidase Inhibition to Abrogate CPT-11 Toxicity
Creators: name: Redinbo, M. R.
name: Venkatesh, M. K.
name: Wallace, B. D.
name: Mani, S.
name: Roberts, A. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Bacterial β-glucuronidases expressed by the symbiotic intestinal microbiota appear to play important roles in drug-induced epithelial cell toxicity in the gastrointestinal (GI) tract. For the anticancer drug CPT-11 (irinotecan) and the nonsteroidal anti-inflammatory drug diclofenac, it has been shown that removal of the glucuronide moieties from drug metabolites by bacterial β-glucuronidases in the GI lumen can significantly damage the intestinal epithelium. Furthermore, selective disruption of bacterial β-glucuronidases by small molecule inhibitors alleviates these side effects, which, for CPT-11 {7-ethyl-10-[4-(1-piperidino)-1-piperidino]}, can be dose limiting. Here we characterize novel microbial β-glucuronidase inhibitors that inhibit Escherichia coli β-glucuronidase in vitro with Ki values between 180 nM and 2 μM, and disrupt the enzyme in E. coli cells, with EC50 values as low as 300 nM. All compounds are selective for E. coli β-glucuronidase without inhibiting purified mammalian β-glucuronidase, and they do not impact the survival of either bacterial or mammalian cells. The 2.8 Å resolution crystal structure of one inhibitor bound to E. coli β-glucuronidase demonstrates that it contacts and orders only a portion of the “bacterial loop” present in microbial, but not mammalian, β-glucuronidases. The most potent compound examined in this group was found to protect mice against CPT-11–induced diarrhea. Taken together, these data advance our understanding of the chemical and structural basis of selective microbial β-glucuronidase inhibition, which may improve human drug efficacy and toxicity.
Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes
Creators: name: Han, T.
name: Proctor, W. R.
name: Ng, C. M.
name: Brouwer, K. L. R.
name: Costales, C. L.
name: Everett, R. S.
name: Thakker, D. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Organic cation transporters (OCTs) are members of the solute carrier 22 family of transporter proteins that are involved in absorption, distribution, and excretion of organic cations. OCT3 is localized in the apical (AP) membrane of enterocytes, but the literature is ambiguous about OCT1 (mOct1) localization, with some evidence suggesting a basolateral (BL) localization in human and mouse enterocytes. This is contrary to our preliminary findings showing AP localization of OCT1 in Caco-2 cell monolayers, an established model of human intestinal epithelium. Therefore, this study aims at determining the localization of OCT1 (mOct1) in Caco-2 cells, and human and mouse enterocytes. Functional studies using OCT1-specific substrate pentamidine showed transporter-mediated AP but not BL uptake in Caco-2 cells and human and mouse intestinal tissues. OCT1 inhibition decreased AP uptake of pentamidine by ∼50% in all three systems with no effect on BL uptake. A short hairpin RNA-mediated OCT1 knockdown in Caco-2 cells decreased AP uptake of pentamidine by ∼50% but did not alter BL uptake. Immunostaining and confocal microscopy in all three systems confirmed AP localization of OCT1 (mOct1). Our studies unequivocally show AP membrane localization of OCT1 (mOct1) in Caco-2 cells and human and mouse intestine. These results are highly significant as they will require reinterpretation of previous drug disposition and drug-drug interaction studies where conclusions were drawn assuming BL localization of OCT1 in enterocytes. Most importantly, these results will require revision of the regulatory guidance for industry in the United States and elsewhere because it has stated that OCT1 is basolaterally localized in enterocytes.
The microbial plankton of Lake Fryxell, southern Victoria Land, Antarctica during the summers of 1992 and 1994
Creators: name: Laybourn-Parry, Johanna
name: James, Mark R
name: McKnight, Diane M
name: Priscu, John
name: Spaulding, Sarah A
name: Shiel, Russell
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Samples collected from Lake Fryxell, southern Victoria Land, Antarctica in January 1992 and 1994 were analysed for the abundance of bacterioplankton and the diversity and abundance of protistan plankton. At the times of sampling, 14 ciliate species and 10 species of autotrophic flagellate were recorded. The samples contained two species of rotifer (Philodina spp.), which formed the first record of planktonic metazoans in the Dry Valley lakes of this region of Antarctica. Bacterial concentrations ranged between 1.0 and 3.8×108 l-1 in the upper oxic waters increasing to 20×108 l-1 in the anoxic waters. Heterotrophic flagellates decreased in abundance down the oxygenated water column, disappearing completely at 9 m, and ranged between 0.28 and 7.39×105 l-1 in abundance. Autotrophic flagellates were much more abundant exhibiting a number of distinct peaks down the water column (1.89–25.3×108 l-1). The ciliated protozoa were very abundant (up to 7720 l-1) in relation to flagellate and bacterial numbers, typical of oligotrophic lakes world-wide. The distribution of the protistan plankton showed marked zonation, probably in response to the differing salinity and temperature gradients in the water column. Possible trophic interactions are discussed and comparisons with other continental Antarctic lakes made.
Writing and Rewriting the Epigenetic Code of Cancer Cells: From Engineered Proteins to Small Molecules
Creators: name: Frye, S.
name: Blancafort, P.
name: Jin, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The epigenomic era has revealed a well-connected network of molecular processes that shape the chromatin landscape. These processes comprise abnormal methylomes, transcriptosomes, genome-wide histone post-transcriptional modifications patterns, histone variants, and noncoding RNAs. The mapping of these processes in large scale by chromatin immunoprecipitation sequencing and other methodologies in both cancer and normal cells reveals novel therapeutic opportunities for anticancer intervention. The goal of this minireview is to summarize pharmacological strategies to modify the epigenetic landscape of cancer cells. These approaches include the use of novel small molecule inhibitors of epigenetic processes specifically deregulated in cancer cells and the design of engineered proteins able to stably reprogram the epigenetic code in cancer cells in a way that is similar to normal cells.
On stochastic perturbations of dynamical systems with a "rough" symmetry. Hierarchy of Markov chains
Creators: name: Freidlin, Mark
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider long-time behavior of dynamical systems perturbed by a small noise. Under certain conditions, a slow component of such a motion, which is most important for long- time evolution, can be described as a motion on the cone of invariant measures of the non- perturbed system. The case of a finite number of extreme points of the cone is considered in this paper. As is known, in the generic case, the long-time evolution can be described by a hierarchy of cycles defined by the action functional for corresponding stochastic processes. This, in particular, allows to study metastable distributions and such effects as stochastic resonance. If the system has some symmetry in the logarithmic asymptotics of transition probabilities (rough symmetry),the hierarchy of cycles should be replaced by a hierarchy of Markov chains and their invariant measures.
description: 14 pages, 4 figures
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Questo studio sostiene la tesi che gli spazi manicomiali rappresentano un percorso attiguo a quello dei lager perché le proprietà assimilative della costruzione narrativa e del cronotopo del lager rispetto a quelle che definiscono lo spazio d’isolamento e abbrutimento non sono, pace Primo Levi, così diverse. La disamina del romanzo La prima verità di Simona Vinci segue quindi le coordinate teoriche disegnate da Michel Foucault in Espaces autres e termina con delle considerazioni riguardanti la struttura empatica del personaggio nonfictional. Le conclusioni confermano una interiorizzazione vinciana della lezione foucaultiana, evidente nell’utilizzazione di spazi consegnati a chi legge dopo un processo di iper-costruzione straniante.
description: This study supports the thesis that spatial notions connected to mental hospital spaces represent a path adjacent to that of the concentration camps. By virtue of the assimilative properties of the narrative construction and the chronotope of the concentration camp we can compare such space to that of isolation and brutalization of mental asyum which are not, pace Primo Levi, so different. The examination of the Simona Vinci’s novel La prima verità follows the theoretical coordinates drawn by Michel Foucault in Espaces autres and ends with considerations regarding the empathic structure of Vinci’s non-fictional character. The conclusions confirm the author's internalization of Foucault's lesson, evident in the use of spaces given to the reader after a process of alienating hyper-construction.
The phosphorus composition of a diverse series of Australian sediments
Creators: name: Baldwin, Darren S
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The P speciation of sediments taken from a range of aquatic systems was determined by a modified version of the SEDEX sequential extraction procedure (Ruttenberg, 1992). Cluster analysis of the data suggested that there was a partial decoupling of the P speciation from the inorganic composition of the sediment. Correlation analysis and P-31 n.m.r. spectroscopy were used in an attempt to resolve the chemical nature of the extracted P species.
G 12 Structural Determinants of Hsp90 Interaction Are Necessary for Serum Response Element-Mediated Transcriptional Activation
Creators: name: Booker, B. K.
name: Smolski, W. C.
name: Peters, K. A.
name: Montgomery, E. R.
name: Tagliatela, A. C.
name: Temple, B. R. S.
name: Jones, A. M.
name: Rogers, S. L.
name: Martin, J. W.
name: Tolbert, C. E.
name: Hamilton, T. P.
name: Meigs, T. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The G12/13 class of heterotrimeric G proteins, comprising the
The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials
Creators: name: Aboshama, Rehab Abdelhamid
name: Shareef, Mohammad Abrar
name: AlAmodi, Abdulhadi A.
name: Kurdi, Wesam
name: Al-Tuhaifi, Mohammed M.
name: Bintalib, Marwah Ghazi
name: Sileem, Sileem Ahmed
name: Abdelazem, Osama
name: Abdelhakim, Ahmed Mohamed
name: Sobh, Ahmed M. A.
name: Elbaradie, Sahar M. Y.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This paper reports a systematic review and meta-analysis of the effectiveness of hyoscine-N-butylbromide (HBB) administration in hysterosalpingography (HSG). Four electronic databases were searched for randomised controlled trials (RCTs) that compared HBB versus placebo or no intervention in infertile women undergoing HSG. Pain during and after HSG and different adverse events including nausea, vomiting, and dizziness were evaluated. Three RCTs with 335 patients were included. The analysis showed HBB was significantly effective in reducing pain during and after HSG (MD = −0.76 mm, 95% CI [−1.35, −0.17], p = 0.01) and (MD = −0.81 mm, 95% CI [−1.07, −0.56], p < 0.001), respectively. There were no significant differences in adverse events between HBB and control groups. The methodological evidence quality was high as evaluated by GRADEpro. In conclusion, this review provides good evidence that prior administration of HBB is effective in reducing induced pain during and after HSG with tolerable side effects.
title: An Application of Spectroscopic Techniques to the Measurement of Electron Density and Temperature in a Brush Cathode Plasma
Creators: name: Patel, Ramabhai M.
Publisher: name: Old Dominion University Libraries
Year: 1971

description: A brief review of the Langmuir probe, microwave and spectroscopic techniques most commonly used to make measurements .of plasma electron temperature and density is presented. Of these various methods, certain spectroscopic methods are applied to the measurements of electron density and temperature in a helium brush cathode plasma. The density measurement is based on the manner in which a series of Stark broadened spectral lines merges into an apparent continuum before the normal series limit is reached. This approach met with only limited success in that the density could be determined only by extrapolating the data obtained. Primarily because of problems associated with the plasma source geometry, the intensities of the spectral lines near the modified series limit were too low to allow them to be ~ recorded, thus necessitating this extrapolation. Procedures used to increase the signal to noise ratio so as to render individual lines more distinguishable are discussed. Included in this discussion is a description of an amplifier circuit which was designed for this purpose and which proved useful. Estimates are given to show the kind of source modifications which would allow a more successful use of this approach to the problem of measuring the plasma electron density in the plasma source studied. The electron temperature was measured by the use of a method employing the measured ratio of the intensities of selected spectral lines.
On the role of quark orbital angular momentum in the proton spin
Creators: name: Zavada, Petr
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the covariant version of the quark-parton model, in which the general rules of the angular momentum composition are accurately taken into account. We demonstrate how these rules affect the relativistic interplay between the quark spins and orbital angular momenta, which collectively contribute to the proton spin. The spin structure functions $g_{1}$ and $g_{2}$ corresponding to the many-quark state $J=1/2$ are studied and it is shown they satisfy constraints and relations well compatible with the available experimental data including proton spin content $ΔΣ\lesssim1/3$. The suggested Lorentz invariant 3D approach for calculation of the structure functions is compared with the approach based on the conventional collinear parton model.
description: 7 pages, 1 figure, Presented at Fourth International Workshop Transversity 2014, 9-13 June, Chia, Cagliary
TANAMI Blazars in the IceCube PeV Neutrino Fields
Creators: name: Krauß, F.
name: Kadler, M.
name: Mannheim, K.
name: Schulz, R.
name: Trüstedt, J
name: Wilms, J.
name: Ojha, R.
name: Ros, E.
name: Anton, G.
name: Baumgartner, W.
name: Beuchert, T.
name: Blanchard, J.
name: Bürkel, C.
name: Carpenter, B.
name: Eberl, T.
name: Edwards, P. G.
name: Eisenacher, D.
name: Elsässer, D.
name: Fehn, K.
name: Fritsch, U.
name: Gehrels, N.
name: Gräfe, C.
name: Großberger, C.
name: Hase, H.
name: Horiuchi, S.
name: James, C.
name: Kappes, A.
name: Katz, U.
name: Kreikenbohm, A.
name: Kreykenbohm, I.
name: Langejahn, M.
name: Leiter, K.
name: Litzinger, E.
name: Lovell, J. E. J.
name: Müller, C.
name: Phillips, C.
name: Plötz, C.
name: Quick, J.
name: Steinbring, T.
name: Stevens, J.
name: Thompson, D. J.
name: Tzioumis, A. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The IceCube Collaboration has announced the discovery of a neutrino flux in excess of the atmospheric background. Due to the steeply falling atmospheric background spectrum, events at PeV energies are most likely of extraterrestrial origin. We present the multiwavelength properties of the six radio brightest blazars positionally coincident with these events using contemporaneous data of the TANAMI blazar sample, including high-resolution images and spectral energy distributions. Assuming the X-ray to γ-ray emission originates in the photoproduction of pions by accelerated protons, the integrated predicted neutrino luminosity of these sources is large enough to explain the two detected PeV events.
description: accepted to A&A, 2 June
Overexpression of Diacylglycerol Kinase   Enhances G q-Coupled G Protein-Coupled Receptor Signaling
Creators: name: Rittiner, J. E.
name: Brings, V. E.
name: Zylka, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Multiple genome-wide association studies have linked diacylglycerol kinase
A Far-Infrared Spectroscopic Survey of Intermediate Redshift (Ultra) Luminous Infrared Galaxies
Creators: name: Magdis, Georgios E.
name: Rigopoulou, D.
name: Hopwood, R.
name: Huang, J. -S
name: Farrah, D.
name: Pearson, C.
name: Alonso-Herrero, A.
name: Bock, J. J.
name: Clements, D.
name: Cooray, A.
name: Griffin, M. J.
name: Oliver, S.
name: Fournon, . Perez
name: Riechers, D.
name: Swinyard, B. M.
name: Scott, D.
name: Thatte, N.
name: Valtchanov, I.
name: Vaccari, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present Herschel far-IR photometry and spectroscopy as well as ground based CO observations of an intermediate redshift (0.21 < z < 0.88) sample of Herschel-selected (ultra)-luminous infrared galaxies (L_IR > 10^11.5L_sun). With these measurements we trace the dust continuum, far-IR atomic line emission, in particular [CII]\,157.7microns, as well as the molecular gas of z~0.3 (U)LIRGs and perform a detailed investigation of the interstellar medium of the population. We find that the majority of Herschel-selected intermediate redshift (U)LIRGs have L_CII/L_FIR ratios that are a factor of about 10 higher than that of local ULIRGs and comparable to that of local normal and high-$z$ star forming galaxies. Using our sample to bridge local and high-z [CII] observations, we find that the majority of galaxies at all redshifts and all luminosities follow a L_CII-L_FIR relation with a slope of unity, from which local ULIRGs and high-z AGN dominated sources are clear outliers. We also confirm that the strong anti-correlation between the L_CII/L_FIR ratio and the far-IR color L_60/L_100 observed in the local Universe holds over a broad range of redshifts and luminosities, in the sense that warmer sources exhibit lower L_CII/L_FIR at any epoch. Intermediate redshift ULIRGs are also characterised by large molecular gas reservoirs and by lower star formation efficiencies compared to that of local ULIRGs. The high L_CII/L_FIR ratios, the moderate star formation efficiencies (L_LIR/L_CO or L_IR/M_gas) and the relatively low dust temperatures of our sample (which are also common characteristics of high-z star forming galaxies with ULIRG-like luminosities) indicate that the evolution of the physical properties of (U)LIRGs between the present day and z > 1 is already significant by z ~ 0.3.
description: Accepted for publication in ApJ
The role of small wetlands in catchment management: their effect on diffuse agricultural pollutants
Creators: name: Raisin, Gregory Wallace
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Despite extensive interest in natural wetlands and their use in waste-water technology, little is known about how effective they are for the control of diffuse agricultural pollution. The impact of a small upland wetland located along a drainage line on different storm generated discharge events and resultant downstream nutrient loads over a two year period was assessed. Results for individual events indicated that the relationship between this wetland and its catchment was variable. An annual nutrient budget was determined for this wetland for the period March 1994 to February 1995. The wetland retained 9.7 kg yr-1 (20.5 kg yr-1) of nitrogen and 1.5 kg yrl (±0.1 kg yr-1) of phosphorus which represented 23% of the nitrogen and 38% of the phosphorus that flowed from this catchment. It is concluded that this form of wetland has a role in strategic catchment management for the interception of nutrients flowing from diffuse agricultural sources.
Polynomial law for controlling the generation of n-scroll chaotic attractors in an optoelectronic delayed oscillator
Creators: name: Márquez, Bicky A.
name: Suárez-Vargas, José J.
name: Ramírez, Javier A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Controlled transitions between a hierarchy of n-scroll attractors are investigated in a nonlinear optoelectronic oscillator. Using the system's feedback strength as a control parameter, it is shown experimentally the transition from Van der Pol-like attractors to 6-scroll, but in general, this scheme can produce an arbitrary number of scrolls. The complexity of every state is characterized by Lyapunov exponents and autocorrelation coefficients.
description: 5 pages, 7 figures
Contrasting X-ray/UV time-lags in Seyfert 1 galaxies NGC 4593 and NGC 7469 using AstroSat observations
Creators: name: Kumari, Kavita
name: Dewangan, G. C.
name: Papadakis, I. E.
name: Beard, Max W. J.
name: McHardy, I. M.
name: Singh, K. P.
name: Bhattacharya, D.
name: Bhattacharyya, S.
name: Chandra, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study accretion disk-corona connection in Seyfert 1 galaxies using simultaneous UV/X-ray observations of NGC 4593 (July 14-18, 2016) and NGC 7469 (October 15-19, 2017) performed with AstroSat. We use the X-ray (0.5-7.0 keV) data acquired with the Soft X-ray Telescope (SXT) and the UV (FUV: 130-180 nm, NUV: 200-300 nm) data obtained with the Ultra-Violet Imaging Telescope (UVIT). We also use the contemporaneous Swift observations of NGC 4593 and demonstrate AstroSat's capability for X-ray/UV correlation studies. We performed UV/X-ray cross-correlation analysis using the Interpolated and the Discrete Cross-Correlation Functions and found similar results. In the case of NGC 4593, we found that the variations in the X-rays lead to those in the FUV and NUV bands by ~ 38 ks and ~ 44 ks, respectively. These UV lags favour the disk reprocessing model, they are consistent with the previous results within uncertainties. In contrast, we found an opposite trend in NGC 7469 where the soft X-ray variations lag those in the FUV and NUV bands by ~ 41 ks and ~ 49 ks, respectively. The hard lags in NGC 7469 favour the Thermal Comptonization model. Our results may provide direct observational evidence for the variable intrinsic UV emission from the accretion disk which acts as the seed for thermal Comptonization in a hot corona in a lamp-post like geometry. The non-detection of disk reverberation photons in NGC 7469, using AstroSat data, is most likely due to a high accretion rate resulting in a hot accretion disk and large intrinsic emission.
description: 14 pages, 20 figures, Accepted for publication in MNRAS
Topological properties of helical Shiba chains with general impurity strength and hybridization
Creators: name: Westström, Alex
name: Pöyhönen, Kim
name: Ojanen, Teemu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recent experiments announced an observation of topological superconductivity and Majorana quasiparticles in Shiba chains, consisting of an array of magnetic atoms deposited on top of a superconductor. In this work we study helical Shiba chains and generalize the microscopic theory of subgap energy bands to a regime where the decoupled magnetic impurity energy and the hybridization of different impurity states can be significant compared to the superconducting gap of the host material. From exact solutions of the Bogoliubov-de Gennes equation we extract expressions for the topological phase boundaries for arbitrary values of the superconducting coherence length. The subgap spectral problem can be formulated as a nonlinear matrix eigenvalue problem from which we obtain an analytical solution for energy bands in the long coherence length limit. Physical consequences and departures from the previously obtained results in the deep-dilute impurity limit are discussed in detail.
description: 10 pages, 8 figures
Spin-helical Dirac states in graphene induced by polar-substrate surfaces with giant spin-orbit interaction: a new platform for spintronics
Creators: name: Eremeev, S. V.
name: Nechaev, I. A.
name: Echenique, P. M.
name: Chulkov, E. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Spintronics, or spin electronics, is aimed at efficient control and manipulation of spin degrees of freedom in electron systems. To comply with demands of nowaday spintronics, the studies of electron systems hosting giant spin-orbit-split electron states have become one of the most important directions providing us with a basis for desirable spintronics devices. In construction of such devices, it is also tempting to involve graphene, which has attracted great attention because of its unique and remarkable electronic properties and was recognized as a viable replacement for silicon in electronics. In this case, a challenging goal is to make graphene Dirac states spin-polarized. Here, we report on absolutely new promising pathway to create spin-polarized Dirac states based on coupling of graphene and polar-substrate surface states with giant Rashba-type spin-splitting. We demonstrate how the spin-helical Dirac states are formed in graphene deposited on the surface of BiTeCl. This coupling induces spin separation of the originally spin-degenerate graphene states and results in fully helical in-plane spin polarization of the Dirac electrons.
description: 5 pages, 3 figures
Waterbirds and aquatic invertebrates of swamps on the Victoria Bonaparte mudflat, northern Western Australia
Creators: name: Halse, S. A
name: Shiel, R. J
name: Pearson, G. B
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The aquatic invertebrate and waterbird faunas of the western part of the Victoria-Bonaparte mudflat, located in the Victoria-Bonaparte biogeographic region of the Kimberley, Western Australia, were surveyed in early 1993. Sixty-two species of waterbird and at least 131 species of aquatic invertebrate were recorded. The mudflat has national significance for some shorebird species, especially Redshanks, and has a significant Asian element in the invertebrate fauna. The survey contributes to growing evidence that the micro-invertebrate fauna of Western Australia is distinctive, but the conservation significance of the area for invertebrates cannot be assessed properly without more information concerning other areas of northern Australia.
The VMC Survey - XII. Star cluster candidates in the Large Magellanic Cloud
Creators: name: Piatti, André E.
name: Guandalini, Roald
name: Ivanov, Valentin D.
name: Rubele, Stefano
name: Cioni, Maria-Rosa L.
name: de Grijs, Richard
name: For, Bi-Qing
name: Clementini, Gisella
name: Ripepi, Vincenzo
name: Anders, Peter
name: Oliveira, Joana M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this work we analyse Colour-Magnitude Diagrams (CMDs) of catalogued star clusters located in the Large Magellanic Cloud (LMC), from a YJKs photometric data set obtained by the Visible and Infrared Survey Telescope for Astronomy (VISTA) survey of the Magellanic Clouds system (VMC). We studied a total of 98 objects of small angular size, typically ~ 11.6 pc in diameter projected towards both uncrowded tile LMC 8_8 and crowded tile LMC 5_5. They populate relatively crowded LMC fields with significant fluctuations in the stellar density, the luminosity function, and the colour distribution as well as uncrowded fields. This cluster sample is aimed at actually probing our performance in reaching the CMD features of clusters with different ages in crowded/uncrowded fields. We applied a subtraction procedure to statistically clean the cluster CMDs from field star contamination. We then matched theoretical isochrones to the background-subtracted CMDs to determine the ages and metallicities of the clusters. We estimated the ages of 65 clusters, which resulted to be in the age range 7.3 < log(t/yr) < 9.55. We also classified as chance grouping of stars 19 previoulsy catalogued clusters, two possible cluster-like asterisms, and one unresolved cluster. For other 8 objects, we could not find a clear star concentration in the Ks images either, so we quoted them as cluster-like asterisms. Finally, we found two previously catalogued single star clusters to be unresolved background galaxies (KMHK747, OGLE366), and one to be a triple cluster system (BSDL 2144).
description: Astronomy & Astrophysics, accepted
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor
Creators: name: Ke, H.
name: Wu, Y.
name: Shao, Y.
name: Cui, W.
name: Zhu, X.
name: Huang, Y.
name: Li, Z.
name: Liang, B.
name: Luo, H.-B.
name: Liu, P.
name: Wan, Y.
name: Huang, M.
name: Hou, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the crystal structures. The best compound, (S)-6-((1-(4-chlorophenyl)ethyl)amino)-1-cyclopentyl-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-day]pyrimidin-4-one [(S)-C33], has an IC50 value of 11 nM against PDE9 and the racemic C33 has bioavailability of 56.5% in the rat pharmacokinetic model. The crystal structures of PDE9 in the complex with racemic C33, (R)-C33, and (S)-C33 reveal subtle conformational asymmetry of two M-loops in the PDE9 dimer and different conformations of two C33 enantiomers. The structures also identified a small hydrophobic pocket that interacts with the tyrosyl tail of (S)-C33 but not with (R)-C33, and is thus possibly useful for improvement of selectivity of PDE9 inhibitors. The asymmetry of the M-loop and the different interactions of the C33 enantiomers imply the necessity to consider the whole PDE9 dimer in the design of inhibitors.
Three-Dimensional Triplet Tracking for LHC and Future High Rate Experiments
Creators: name: Schöning, Andre
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The hit combinatorial problem is a main challenge for track reconstruction and triggering at high rate experiments. At hadron colliders the dominant fraction of hits is due to low momentum tracks for which multiple scattering (MS) effects dominate the hit resolution. MS is also the dominating source for hit confusion and track uncertainties in low energy precision experiments. In all such environments, where MS dominates, track reconstruction and fitting can be largely simplified by using three-dimensional (3D) hit-triplets as provided by pixel detectors. This simplification is possible since track uncertainties are solely determined by MS if high precision spatial information is provided. Fitting of hit-triplets is especially simple for tracking detectors in solenoidal magnetic fields. The over-constrained 3D-triplet method provides a complete set of track parameters and is robust against fake hit combinations. The triplet method is ideally suited for pixel detectors where hits can be treated as 3D-space points. With the advent of relatively cheap and industrially available CMOS-sensors the construction of highly granular full scale pixel tracking detectors seems to be possible also for experiments at LHC or future high energy (hadron) colliders. In this paper tracking performance studies for full-scale pixel detectors, including their optimisation for 3D-triplet tracking, are presented. The results obtained for different types of tracker geometries and different reconstruction methods are compared. The potential of reducing the number of tracking layers and -- along with that -- the material budget using this new tracking concept is discussed. The possibility of using 3D-triplet tracking for triggering and fast online reconstruction is highlighted.
description: Proceedings of the WIT2014 Workshop on Intelligent Tracking. 10 Pages, 8 figures. Submitted to JINST
Amaricoccus gen. nov., a Gram-Negative Coccus Occurring in Regular Packages or Tetrads, Isolated from Activated Sludge Biomass, and Descriptions of A. veronensis sp. nov., A. tamworthensis sp. nov., A. macauensis sp. nov., and A. kaplicensis sp. nov
Creators: name: Maszenan, A. M
name: Seviour, R. J
name: Patel, B. K. C
name: Rees, G. N
name: McDougall, B. M
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Three isolates of gram-negative bacteria, strains Ben 102T, Ben 103T, and Ben 104T, were obtained in pure culture by micromanipulation from activated sludge biomass from wastewater treatment plants in Italy, Australia, and Macau, respectively. These isolates all had a distinctive morphology; the cells were cocci that usually were arranged in tetrads. Based on this criterion, they resembled other bacteria from activated sludge previously called "G" bacteria. On the basis of phenotypic characteristics and the results of 16S ribosomal DNA sequence analyses, the three isolates were very similar to each other, but were sufficiently different from their closest phylogenetic relatives (namely, the genera Rhodobacter, Rhodovulum, and Paracoccus in the subdivision of the Proteobacteria) to be placed in a new genus, Amaricoccus gen. nov. Each of the three isolates represents a new species of the genus Amaricoccu; strains Ben 102T, Ben 103T, and Ben 104Tare named Amaricoccus veronensis, Amaricoccus tamworthensis, and Amaricoccus macauensis, respectively. An isolate designated Ben 101T, which was isolated independently by Cech and Hartman in Kaplice, Czech Republic, was also characterized and belongs to the same genus. We propose that the isolate of Cech and Hartman should be placed in another new species, Amaricoccus kaplicensis.
Correlating Changes in Spot Filling Factors with Stellar Rotation: The Case of LkCa 4
Creators: name: Paolino, Facundo Pérez
name: Bary, Jeffrey S.
name: Petersen, Michael S.
name: Ward-Duong, Kimberly
name: Tofflemire, Benjamin M.
name: Follette, Katherine B.
name: Mach, Heidi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a multi-epoch spectroscopic study of LkCa 4, a heavily spotted non-accreting T Tauri star. Using SpeX at NASA's Infrared Telescope Facility (IRTF), 12 spectra were collected over five consecutive nights, spanning $\approx$ 1.5 stellar rotations. Using the IRTF SpeX Spectral Library, we constructed empirical composite models of spotted stars by combining a warmer (photosphere) standard star spectrum with a cooler (spot) standard weighted by the spot filling factor, $f_{spot}$. The best-fit models spanned two photospheric component temperatures, $T_{phot}$ = 4100 K (K7V) and 4400 K (K5V), and one spot component temperature, $T_{spot}$ = 3060 K (M5V) with an $A_V$ of 0.3. We find values of $f_{spot}$ to vary between 0.77 and 0.94 with an average uncertainty of $\sim$0.04. The variability of $f_{spot}$ is periodic and correlates with its 3.374 day rotational period. Using a mean value for $f^{mean}_{spot}$ to represent the total spot coverage, we calculated spot corrected values for $T_{eff}$ and $L_\star$. Placing these values alongside evolutionary models developed for heavily spotted young stars, we infer mass and age ranges of 0.45-0.6 $M_\odot$ and 0.50-1.25 Myr, respectively. These inferred values represent a twofold increase in the mass and a twofold decrease in the age as compared to standard evolutionary models. Such a result highlights the need for constraining the contributions of cool and warm regions of young stellar atmospheres when estimating $T_{eff}$ and $L_\star$ to infer masses and ages as well as the necessity for models to account for the effects of these regions on the early evolution of low-mass stars.
description: 21 pages, 9 Figures; Accepted for publication in ApJ