cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bryobia (Bryobia) gigas Auger, Arabuli and Migeon 2015
Creators: name: Barbar, Ziad
name: Auger, Philippe
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Tetranychidae
Bryobia
Bryobia gigas

description: Bryobia (Bryobia) gigas Auger, Arabuli and Migeon, 2015
Four females of this species were collected from soil litter, Attabiyyat, south-west of Latakia city, Syria (35°30’24” N, 35°46’49” E), 23 April 2019. This species has been already collected from Bituminaria bituminosa (L.) in Syria (Zeity and Srinivasa, 2019) but this host plant was no present in the place where we collected these specimens.
description: Published as part of Barbar, Ziad & Auger, Philippe, 2020, New records of the genusBryobia (Acari: Tetranychidae) from Syria with description of a new species, pp. 268-288 in Acarologia 60 (2) on page 281, DOI: 10.24349/acarologia/20204367, http://zenodo.org/record/4503360
Auswirkungen der SARS-CoV‑2-Pandemie auf die universitäre Hals-Nasen-Ohren-Heilkunde im Bereich der Forschung, Lehre und Weiterbildung
Creators: name: Stöver, T.
name: Dazert, S.
name: Plontke, S. K.
name: Kramer, S.
name: Ambrosch, P.
name: Arens, C.
name: Betz, C.
name: Beutner, D.
name: Bohr, C.
name: Bruchhage, K.-L.
name: Canis, M.
name: Dietz, A.
name: Guntinas-Lichius, O.
name: Hagen, R.
name: Hosemann, W.
name: Iro, H.
name: Klussmann, J. P
name: Knopf, A.
name: Lang, S.
name: Leinung, M.
name: Lenarz, T.
name: Löwenheim, H.
name: Matthias, C.
name: Mlynski, R.
name: Olze, H.
name: Park, J.
name: Plinkert, P.
name: Radeloff, A.
name: Rotter, N.
name: Rudack, C.
name: Bozzato, A.
name: Schipper, J.
name: Schrader, M.
name: Schuler, P. J.
name: Strieth, S.
name: Stuck, B. A.
name: Volkenstein, S.
name: Westhofen, M.
name: Wolf, G.
name: Wollenberg, B.
name: Zahnert, T.
name: Zenk, J.
name: Hoffmann, T. K.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: COVID-19; SARS-CoV-2 pandemic; University hospitals; Otorhinolaryngology; ORL; Research; Teaching; Specialist training; Residency
subject: 610 Medizin

description: Hintergrund
Ab Frühjahr 2020 kam es zur weltweiten Verbreitung von SARS-CoV‑2 mit der heute als erste Welle der Pandemie bezeichneten Phase ab März 2020. Diese resultierte an vielen Kliniken in Umstrukturierungen und Ressourcenverschiebungen. Ziel unserer Arbeit war die Erfassung der Auswirkungen der Pandemie auf die universitäre Hals-Nasen-Ohren(HNO)-Heilkunde für die Forschung, Lehre und Weiterbildung.

Material und Methoden
Die Direktorinnen und Direktoren der 39 Universitäts-HNO-Kliniken in Deutschland wurden mithilfe einer strukturierten Online-Befragung zu den Auswirkungen der Pandemie im Zeitraum von März bis April 2020 auf die Forschung, Lehre und die Weiterbildung befragt.

Ergebnisse
Alle 39 Direktorinnen und Direktoren beteiligten sich an der Umfrage. Hiervon gaben 74,4 % (29/39) an, dass es zu einer Verschlechterung ihrer Forschungstätigkeit infolge der Pandemie gekommen sei. Von 61,5 % (24/39) wurde berichtet, dass pandemiebezogene Forschungsaspekte aufgegriffen wurden. Von allen Kliniken wurde eine Einschränkung der Präsenzlehre berichtet und 97,5 % (38/39) führten neue digitale Lehrformate ein. Im Beobachtungszeitraum sahen 74,4 % der Klinikdirektoren die Weiterbildung der Assistenten nicht gefährdet.

Schlussfolgerung
Die Ergebnisse geben einen Einblick in die heterogenen Auswirkungen der Pandemie. Die kurzfristige Bearbeitung pandemiebezogener Forschungsthemen und die Einführung innovativer digitaler Konzepte für die studentische Lehre belegt eindrücklich das große innovative Potenzial und die schnelle Reaktionsfähigkeit der HNO-Universitätskliniken, um auch während der Pandemie ihre Aufgaben in der Forschung, Lehre und Weiterbildung bestmöglich zu erfüllen.
Scoping Review of Scientific Publications on Occupational Therapy in Dual Pathology
Creators: name: Talavera-Valverde, Miguel-Ángel
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences
subject: Other Life Sciences
subject: Psychiatry and Psychology

description: The purpose of this scoping review is to provide an overview of the current state of the literature related to occupational therapy in dual pathology. By searching and synthesizing published academic and grey literature, this review will map the current themes and narratives in Occupational Therapy research within this context. Ultimately, this review aims to categorize and analyze the existing research and literature.
Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma
Creators: name: Glutsch, Valerie
name: Kneitz, Hermann
name: Gesierich, Anja
name: Goebeler, Matthias
name: Haferkamp, Sebastian
name: Becker, Jürgen C.
name: Ugurel, Selma
name: Schilling, Bastian
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Merkel cell carcinoma; Resistance; Avelumab; Ipilimumab; Nivolumab
subject: 610 Medizin

description: Background
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies are limited to the PD-L1 inhibitor avelumab. For avelumab-refractory patients, efficient and safe treatment options are lacking.

Methods
At three different sites in Germany, clinical and molecular data of patients with metastatic MCC being refractory to the PD-L1 inhibitor avelumab and who were later on treated with combined IPI/NIVO were retrospectively collected and evaluated.

Results
Five patients treated at three different academic sites in Germany were enrolled. Three out of five patients investigated for this report responded to combined IPI/NIVO according to RECIST 1.1. Combined immunotherapy was well tolerated without any grade II or III immune-related adverse events. Two out of three responders to IPI/NIVO received platinum-based chemotherapy in between avelumab and combined immunotherapy.

Conclusion
In this small retrospective study, we observed a high response rate and durable responses to subsequent combined immunotherapy with IPI/NIVO in avelumab-refractory metastatic MCC patients. In conclusion, our data suggest a promising activity of second- or third-line PD-1- plus CTLA-4-blockade in patients with anti-PD-L1-refractory MCC.
Deconfinement to confinement by generalizing BRST symmetry on the sphere
Creators: name: Raval, Haresh
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently it has been shown that the theory in the quadratic gauge on 4-sphere, $\mathbb{S}^{4}$ consists of two phases namely, the confined and the deconfined phases. A suitable finite field dependent BRST (FFBRST) transformation interrelates two different gauge fixed theories. In this paper, we use the FFBRST technique on the curved space for the first time and elaborate a novel application of it. We propose two different formulations of this technique that transform the deconfined phase action on sphere to the confined phase action on sphere inside the quadratic gauge. Both proposed passages change the phase with BRST invariance to the phase without BRST invariance unlike usual connections where the FFBRST operation leave the BRST symmetry intact and there is a unique field theoretic essence of them, which makes them particularly important to study. Thus, the two different field redefinitions act as a new mechanism that execute phase transition between two real QCD phases on 4-sphere other than ghost condensation process.
description: 14 pages, published
Agrilus abstersus Horn
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus abstersus

description: Agrilus abstersus Horn
PUE, 1 mi N Coxcatlán, 28-VII-73, DSVC; SIN, Río Fuerte & Hwy. 15, 20 m, 8-9-VII-79, CLBC.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 6, DOI: 10.5281/zenodo.273645
Myconinae Fennah 1950
Creators: name: Brysz, Alicja M.
name: Stroiński, Adam
name: Szwedo, Jacek
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Achilidae

description: Subfamily Myconinae Fennah, 1950
Emended diagnosis
Vertex often strongly produced anteriorly of margin of the compound eyes, with a rounded anterior margin. Lora visible in ventral view. Pronotum with postocular carina present. Metatibial lateral spines in various number, subgenual one present, the pattern with more than one cuticular lateral spine except genual spine only in this subfamily. Tegmen (fore wing) with length/width on clavus apex proportion up from 3.5; postcosts area not widened; low number of RA terminals (1 to 4). Hind wing second anal vein simple, more or less straight and apically dilated, usually not reaching wing margin by a considerable distance; median fold usually reaching wing margin.
description: Published as part of Brysz, Alicja M., Stroiński, Adam & Szwedo, Jacek, 2024, A new tribe of scaphocephalic Achilidae from South Africa (Hemiptera: Fulgoromorpha), pp. 151-176 in European Journal of Taxonomy 958 (1) on page 153, DOI: 10.5852/ejt.2024.958.2667, http://zenodo.org/record/13861768
Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation
Creators: name: Evert, Katja
name: Dienemann, Thomas
name: Brochhausen, Christoph
name: Lunz, Dirk
name: Lubnow, Matthias
name: Ritzka, Markus
name: Keil, Felix
name: Trummer, Matthias
name: Scheiter, Alexander
name: Salzberger, Bernd
name: Reischl, Udo
name: Gessner, Andre
name: Jantsch, Jonathan
name: Calvisi, Diego F.
name: Evert, Matthias
name: Schmidt, Barbara
name: Simon, Michaela
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ; COVID-19; Autopsy; Fungal infection; Mycosis; Macrophage activation syndrome
subject: 610 Medizin

description: Between April and June 2020, i.e., during the first wave of pandemic coronavirus disease 2019 (COVID-19), 55 patients underwent long-term treatment in the intensive care unit at the University Hospital of Regensburg. Most of them were transferred from smaller hospitals, often due to the need for an extracorporeal membrane oxygenation system. Autopsy was performed in 8/17 COVID-19-proven patients after long-term treatment (mean: 33.6 days). Autopsy revealed that the typical pathological changes occurring during the early stages of the disease (e.g., thrombosis, endothelitis, capillaritis) are less prevalent at this stage, while severe diffuse alveolar damage and especially coinfection with different fungal species were the most conspicuous finding. In addition, signs of macrophage activation syndrome was detected in 7 of 8 patients. Thus, fungal infections were a leading cause of death in our cohort of severely ill patients and may alter clinical management of patients, particularly in long-term periods of treatment.
Achiplectini Brysz, Stroiński & Szwedo, 2024, trib. nov
Creators: name: Brysz, Alicja M.
name: Stroiński, Adam
name: Szwedo, Jacek
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Achilidae

description: Achiplectini trib. nov
urn:lsid:zoobank.org:act: 8CE175F6-30F2-40EF-BD3D-FAFC6506A6AC
Type genus
Achiplecton gen. nov., here designated.
Diagnosis
Apical portions of tegmina not overlapping (exceptional feature among Achilidae); apex of clavus blunt, claval veins Pcu+A 1 reaching margin at same point as CuP (clavus ‘open’ in other tribes, with terminal Pcu+A 1 reaching bent section of CuP); hind wing with median vein leaving the base with a short common stalk with ScP+ R, ‘arculus’ (the very base of CuA), absent, viz. basal cell absent; median fold entering cubital area (as in Plectoderini); second anal vein of hind wing simple, not reaching margin, dilated posteriorly; frons with intermediate carina, separating ‘acrometope’ sensu Emeljanov (as in Rhotalini and extinct Waghildini); lateral carinae of postclypeus well developed, not prolonged on anteclypeus (similar as in extinct Waghildini; prolonged to anteclypeus in Rhotalini, Myconini, Mycarini; vestigial to absent in Plectoderini; absent in Amphignomini); anteclypeus narrow, oval, with median carina; subantennal carinae absent (present in Amphignomini); disc of pronotum not covering vertex (coryphe); metatibia with single lateral cuticular spine (as in Plectoderini); basi- and midmetatarsus with subapical platellae, except the lateral teeth. The male phallic complex retracted deep into the abdomen. Male medioventral projection of pygofer present; lateral margin of pygofer without projections. Anal tube flattened, in males, with epiproct short and paraproct short. Periandrium symmetrical, three-lobate. Connective long, Y-shaped. Female 7 th sternite (pregenital sternite, last sternite) “smooth”, without any additional lobe. Gonoplac and endogonocoxal process trilobate. Bursa copulatrix single-pouched, ornamented.
Distribution
Afrotropical region, Southern African, the Cape.
Composition
Only type genus so far.
description: Published as part of Brysz, Alicja M., Stroiński, Adam & Szwedo, Jacek, 2024, A new tribe of scaphocephalic Achilidae from South Africa (Hemiptera: Fulgoromorpha), pp. 151-176 in European Journal of Taxonomy 958 (1) on pages 153-154, DOI: 10.5852/ejt.2024.958.2667, http://zenodo.org/record/13861768
Agrilus abductus Horn
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus abductus

description: Agrilus abductus Horn
HGO, 3.3 mi beyond Santuario, road to Tixqui, 2262 m, 20°41.165’, 99°08.910, 12/ 14-VI- 2004, juniper-oak-pinyon-mixed hardwood forest, RLWE.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 6, DOI: 10.5281/zenodo.273645
THE COMPARATIVE ANALYSIS OF ADJECTIVES IN ENGLISH AND UZBEK LANGUAGES
Creators: name: Zinatdinova, Arzayim
Publisher: name: Zenodo
Year: 2024

description: This article provides a comparative analysis of English and Uzbek adjectives, exploring their similarities and differences in usage, structure, and grammatical features. Key areas such as the position of adjectives, agreement with nouns, degrees of comparison, order of adjectives, and the use of intensifiers are discussed in detail. By highlighting these aspects, the article aims to help language learners understand the unique characteristics of adjectives in both languages, thereby enhancing their linguistic proficiency.
Abatacept as salvage therapy in chronic graft-versus-host disease—a retrospective analysis
Creators: name: Wertheimer, Tobias
name: Dohse, Marius
name: Afram, Gabriel
name: Weber, Daniela
name: Heidenreich, Martin
name: Holler, Barbara
name: Kattner, Anna-Sophia
name: Neubauer, Andreas
name: Mielke, Stephan
name: Ljungman, Per
name: Holler, Ernst
name: Herr, Wolfgang
name: Edinger, Matthias
name: Martínez, Antonio Pérez
name: Fante, Matthias
name: Wolff, Daniel
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ; Chronic graft-versus-host disease; Abatacept; Salvage therapy; Bronchiolitis obliterans syndrome
subject: 610 Medizin

description: The immunomodulatory fusion protein abatacept has recently been investigated for the treatment of steroid-refractory chronic graft-versus-host disease (cGvHD) in a phase 1 clinical trial. We analyzed the safety and efficacy of abatacept for cGvHD therapy in a retrospective study with 15 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and received abatacept for cGvHD with a median age of 49 years. Grading was performed as part of the clinical routine according to the National Institute of Health's (NIH) consensus criteria at initiation of abatacept and 1, 3, 6, 9 and 12 months thereafter. The median time of follow-up was 191 days (range 55-393 days). Best overall response rate (ORR) was 40%. In particular, patients with bronchiolitis obliterans syndrome showed significant clinical improvement and durable responses following abatacept treatment with a response rate of 89% based on improvement in lung severity score (n = 6) or stabilized lung function (n = 4) or both (n = 3). Infectious complications CTCAE degrees III or higher were observed in 3/15 patients. None of the patients relapsed from the underlying malignancy. Thus, abatacept appears to be a promising treatment option for cGvHD, in particular for patients with lung involvement. However, further evaluation within a phase 2 clinical trial is required.
Agrilus acaciae Fisher
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus acaciae

description: Agrilus acaciae Fisher
NL, 5 mi S Monterrey, 3-VI-61, CNC; QRO, Hwy. 69, 27 km NW Jalpan at Río Santa Marta, 3-VI-87, FSCA; SLP, 4.1 mi E Cd. del Maíz, 11-VI-87, FSCA.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 6, DOI: 10.5281/zenodo.273645
AdapTics: A Toolkit for Creative Design and Integration of Real-Time Adaptive Mid-Air Ultrasound Tactons
Creators: name: John, Kevin
name: Li, Yinan
name: Seifi, Hasti
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Mid-air ultrasound haptic technology can enhance user interaction and immersion in extended reality (XR) applications through contactless touch feedback. Yet, existing design tools for mid-air haptics primarily support creating tactile sensations (i.e., tactons) which cannot change at runtime. These tactons lack expressiveness in interactive scenarios where a continuous closed-loop response to user movement or environmental states is desirable. This paper introduces AdapTics, a toolkit featuring a graphical interface for rapid prototyping of adaptive tactons-dynamic sensations that can adjust at runtime based on user interactions, environmental changes, or other inputs. A software library and a Unity package accompany the graphical interface to enable integration of adaptive tactons in existing applications. We present the design space offered by AdapTics for creating adaptive mid-air ultrasound tactons and show the design tool can improve Creativity Support Index ratings for Exploration and Expressiveness in a user study with 12 XR and haptic designers.
description: Source code available: https://github.com/AdaptiveHaptics . To be published in Proceedings of the CHI Conference on Human Factors in Computing Systems (CHI '24)
Bridge to Non-Barrier Communication: Gloss-Prompted Fine-grained Cued Speech Gesture Generation with Diffusion Model
Creators: name: Lei, Wentao
name: Liu, Li
name: Wang, Jun
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Cued Speech (CS) is an advanced visual phonetic encoding system that integrates lip reading with hand codings, enabling people with hearing impairments to communicate efficiently. CS video generation aims to produce specific lip and gesture movements of CS from audio or text inputs. The main challenge is that given limited CS data, we strive to simultaneously generate fine-grained hand and finger movements, as well as lip movements, meanwhile the two kinds of movements need to be asynchronously aligned. Existing CS generation methods are fragile and prone to poor performance due to template-based statistical models and careful hand-crafted pre-processing to fit the models. Therefore, we propose a novel Gloss-prompted Diffusion-based CS Gesture generation framework (called GlossDiff). Specifically, to integrate additional linguistic rules knowledge into the model. we first introduce a bridging instruction called \textbf{Gloss}, which is an automatically generated descriptive text to establish a direct and more delicate semantic connection between spoken language and CS gestures. Moreover, we first suggest rhythm is an important paralinguistic feature for CS to improve the communication efficacy. Therefore, we propose a novel Audio-driven Rhythmic Module (ARM) to learn rhythm that matches audio speech. Moreover, in this work, we design, record, and publish the first Chinese CS dataset with four CS cuers. Extensive experiments demonstrate that our method quantitatively and qualitatively outperforms current state-of-the-art (SOTA) methods. We release the code and data at https://glossdiff.github.io/.
Concomitant lorazepam use and antidepressive efficacy of repetitive transcranial magnetic stimulation in a naturalistic setting
Creators: name: Deppe, Markus
name: Abdelnaim, Mohamed A.
name: Hebel, Tobias
name: Kreuzer, P. M.
name: Langguth, Berthold
name: Schecklmann, Martin
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: MAJOR DEPRESSIVE DISORDER; GAMMA-AMINOBUTYRIC-ACID; RECEPTOR SUBUNIT EXPRESSION; TREATMENT-RESISTANT DEPRESSION; GABA CONCENTRATIONS; BENZODIAZEPINE USE; CORTEX GABA; THETA BURST; SAFETY; RTMS; rTMS; Brain stimulation; Depression; Affective disorder; Lorazepam; Benzodiazepine
subject: 610 Medizin

description: Background/objectives: Repetitive transcranial magnetic stimulation (rTMS) has been established as an effective therapeutic intervention for the treatment of depression. Preliminary data suggest that the efficacy of rTMS is reduced in patients taking benzodiazepines (BZD). Here, we use real-world data from a large sample to investigate the influence of lorazepam on the effectiveness of rTMS. Methods From a retrospective cohort of clinically depressed patients that were treated with rTMS, we compared 176 patients not taking any BZD with 73 patients taking lorazepam with respect to changes in the Hamilton Depression Rating Scale (HRDS). Results Both groups improved during rTMS according to HRDS scores, but the amelioration of symptoms was significantly less pronounced in patients taking lorazepam (18% vs. 38% responders in the non-lorazepam group). We could not see any association of intake regimen of lorazepam with response in rTMS. Conclusion Our observational study suggests that intake of lorazepam impedes the response to rTMS. The impact of lorazepam and other BZD on rTMS should receive more attention and be further investigated in prospective, hypothesis-based treatment studies to determine causal relationships between medication treatments and outcome. This could lead to specific recommendations for pharmacological treatment for depressed patients undergoing rTMS.
Agrilus admirabilis Hespenheide
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus admirabilis

description: Agrilus admirabilis Hespenheide
GRO, 16 km NW Iguala, 19-24-VII-83, EMEC. MICH, 5.4 mi N Nueva Italia, 17-VI-87, FSCA.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 6, DOI: 10.5281/zenodo.273645
Metamizole but not ibuprofen reduces the plasma concentration of sertraline: Implications for the concurrent treatment of pain and depression/anxiety disorders
Creators: name: Gaebler, Arnim Johannes
name: Schoretsanitis, Georgios
name: Ben Omar, Nagia
name: Haen, Ekkehard
name: Endres, Katharina
name: Hiemke, Christoph
name: Paulzen, Michael
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: SEROTONIN REUPTAKE INHIBITORS; INDUCTION; PROFILE; depression; dipyrone; metamizole; pain; pharmacokinetics; sertraline; therapeutic drug monitoring
subject: 610 Medizin
subject: 615 Pharmazie

description: Aim Comorbidity of pain and depression or anxiety is a challenging clinical phenomenon, often requiring the concurrent application of antidepressant and analgesic drugs. Growing evidence suggests that the analgesic metamizole exhibits cytochrome P450 inducing properties. In the present study, we assessed the impact of metamizole and ibuprofen on plasma concentrations of the selective serotonin reuptake inhibitor sertraline. Methods Out of a therapeutic drug monitoring (TDM) database, three groups of patients were compared: patients receiving sertraline and metamizole (n = 15), patients receiving sertraline and ibuprofen (n = 19), and a matched control group without one of the analgesics (n = 19). Results Metamizole was associated with 67% lower median sertraline plasma concentrations compared to the control group (14vs42 ng/mL,P< 0.001). In contrast, differences between the ibuprofen group and the control group did not reach statistical significance (31vs42 ng/mL,P= 0.128). Moreover, the metamizole group demonstrated lower dose-adjusted drug concentrations than the ibuprofen group (0.10vs0.26 (ng/mL)/(mg/day),P= 0.008). Finally, the metamizole group exhibited a higher proportion of patients whose sertraline concentrations were below the therapeutic reference range (40% in the metamizole group, 5% in the ibuprofen group, 0% in the control group,P= 0.005) indicating therapeutically insufficient drug concentrations. Conclusion Our findings support preliminary evidence that metamizole acts as a potent inductor of cytochrome P450 isoenzymes CYP2B6 and CYP3A4. We observed a clinically meaningful pharmacokinetic interaction between metamizole and sertraline, leading to insufficiently low sertraline drug concentrations. Clinicians should therefore consider alternative drug combinations or apply TDM-guided dose adjustment of sertraline.
title: "Adorazione del Bambino", Maestro del Tondo Borghese, inv. 352 (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: MARTINI, ELISA
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Impact of salt and the osmoprotective transcription factor NFAT-5 on macrophages during mechanical strain
Creators: name: Schröder, Agnes
name: Leikam, Alexandra
name: Käppler, Paul
name: Neubert, Patrick
name: Jantsch, Jonathan
name: Neuhofer, Wolfgang
name: Deschner, James
name: Proff, Peter
name: Kirschneck, Christian
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: NECROSIS-FACTOR-ALPHA; ORTHODONTIC TOOTH MOVEMENT; OSTEOCLAST DIFFERENTIATION; GENE-EXPRESSION; BONE-RESORPTION; HPDL CELLS; TISSUE; PCR; INTERLEUKIN-1-BETA; OSTEOPROTEGERIN; Macrophages; NFAT-5; orthodontics; salt; sodium chloride
subject: 610 Medizin

description: Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl and NFAT-5 on the expression pattern of macrophages in a model of simulated OTM. RAW264.7 macrophages were exposed for 4 h to 2 g cm(-2)compressive or 16% tensile or no mechanical strain (control), with or without the addition of 40 mmNaCl. We analyzed the expression of inflammatory genes and proteins [tumor necrosis factor (TNF), interleukin (IL)-6 and prostaglandin endoperoxide synthase-2 (Ptgs-2)/prostaglandin E2 (PG-E2)] by real-time-quantitative PCR and ELISA. To investigate the role of NFAT-5 in these responses, NFAT-5 was both constitutively expressed and silenced. Salt and compressive strain, but not tensile strain increased the expression of NFAT-5 and most tested inflammatory factors in macrophages. NaCl induced the expression ofPtgs-2/PG-E2 and TNF, whereas secretion of IL-6 was inhibited. Similarly, a constitutive expression of NFAT-5 reduced IL-6 expression, while increasingPtgs-2/PG-E2 and TNF expression. Silencing of NFAT-5 upregulated IL-6 and reducedPtgs-2/PG-E2 and TNF expression. Salt had an impact on the expression profile of macrophages as a reaction to compressive and tensile strain that occur during OTM. This was mediated via NFAT-5, which surprisingly also seems to play a regulatory role in mechanotransduction of compressive strain. Sodium accumulation in the periodontal ligament caused by dietary salt consumption might propagate local osteoclastogenesis via increased local inflammation and thus OTM velocity, but possibly also entail side effects such as dental root resorptions or periodontal bone loss.
title: Compactness and convergence rates in the combinatorial integral approximation decomposition
Creators: name: Kirches, Christian
name: Manns, Paul
name: Ulbrich, Stefan
Publisher: name: Springer
Year: 2024

description: The combinatorial integral approximation decomposition splits the optimization of a discrete-valued control into two steps: solving a continuous relaxation of the discrete control problem, and computing a discrete-valued approximation of the relaxed control. Different algorithms exist for the second step to construct piecewise constant discrete-valued approximants that are defined on given decompositions of the domain. It is known that the resulting discrete controls can be constructed such that they converge to a relaxed control in the weak* topology of L∞ if the grid constant of this decomposition is driven to zero. We exploit this insight to formulate a general approximation result for optimization problems, which feature discrete and distributed optimization variables, and which are governed by a compact control-to-state operator. We analyze the topology induced by the grid refinements and prove convergence rates of the control vectors for two problem classes. We use a reconstruction problem from signal processing to demonstrate both the applicability of the method outside the scope of differential equations, the predominant case in the literature, and the effectiveness of the approach.
Study of bound and resonant states of NS molecule in the R-matrix approach
Creators: name: Iacob, F.
name: Meltzer, T.
name: Mezei, J. Zs.
name: Schneider, I. F.
name: Tennyson, J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The bound and resonance states along with corresponding autoionization widths for nitrogen sulphide (NS) molecule are determined using electron NS$^+$ cation scattering calculations. The calculations are performed for $^2Σ^+$, $^2Π$ and $^2Δ$ total symmetries using the ab initio R-matrix method for both bound and continuum states. Calculations are performed on a grid of 106 points for internuclear separations between 1.32 and 3 $Å$. The resonance states yield dissociative potential curves which, when considered together with their widths, provide input for models of different electron-cation collision processes including dissociative recombination, and rotational and vibrational excitation. Curves and couplings which will lead directly to dissociative recombination are identified.
description: 7 pages, 11 figures
Agrilus affinis Waterhouse
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus affinis

description: Agrilus affinis Waterhouse
MEX, 7.4 km NW Temascaltepec, 2148 m, 20-VIII-81, CLBC.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 6, DOI: 10.5281/zenodo.273645
Juraheterosmylus Wang, Liu, Ren & Shih, 2010, gen. nov.
Creators: name: Wang, Yongjie
name: Liu, Zhiqi
name: Ren, Dong
name: Shih, Chungkun
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Osmylidae
Juraheterosmylus

description: Genus: Juraheterosmylus gen. nov.
Type species: Juraheterosmylus antiquatus sp. nov.
Etymology. The new genus name is a combination of Jura- (meaning, Jurassic) and Heterosmylus (a genus of Protosmylinae).
Diagnosis. Forewing moderate size (19–24mm long). Membrane hyaline, with few spots; trichosors present along anterior and distal margins. Costal region broad, cross-veins simple and with few distal forks. r1-rs cross-veins no more than 10 branches. Rs branches slightly zigzagged in middle, cross-veins in radial sector arranged regularly, forming 3 rows of gradate series. MP forked close to the separation of MA from Rs. Cu forked at the wing base, both branches approximately with equal length. A1 long, beyond the half of CuP. A2 and A3 well developed, with 2–3 distal branches.
Remarks. Juraheterosmylus is assigned to Protosmylinae by the following characters: forewing with few markings besides pterostigma; cross-veins in redial sector arranged regularly, less than 3 in number besides the gradate series; Rs branches slightly zigzagged. However it also possesses some attributes that are different from the other genera: six r1-rs cross-veins (while the number commonly exceeds 10 others); complicated distal forks of Rs (deep and multiple forks in the new genus), while Rs branches generally have shallow simple distal forks; Cu forked at the wing base, forming two approximately equal branches, while the fork commonly with a short distant to the wing base and both branches distinctly are unequal. Furthermore the new genus also has a relatively well-developed anal region, e.g. A2 and A3 full-developed. The new genus is the oldest record of Protosmylinae. Juraheterosmylus shows evidently more complicated venation that definitely separates it from other genera and is likely the most primitive protosmylines, representing a stem-group of Protosmylinae.
description: Published as part of Wang, Yongjie, Liu, Zhiqi, Ren, Dong & Shih, Chungkun, 2010, A new genus of Protosmylinae from the Middle Jurassic of China (Neuroptera: Osmylidae), pp. 45-53 in Zootaxa 2480 on pages 46-47, DOI: 10.5281/zenodo.195411
Agrilus albofasciatus Waterhouse
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus albofasciatus

description: Agrilus albofasciatus Waterhouse
GRO, 1 mi NE La Laguna, 17-VII-84, CHAH, TAMU.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 7, DOI: 10.5281/zenodo.273645
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis
Creators: name: Feder, Susanne
name: Wiest, Reiner
name: Weiss, Thomas S.
name: Aslanidis, Charalampos
name: Schacherer, Doris
name: Krautbauer, Sabrina
name: Liebisch, Gerhard
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: HEPATITIS-C VIRUS; CIRCULATING PCSK9; MELD SCORE; CHILD-PUGH; INFLAMMATION; CHEMERIN; PLASMA; EXPRESSION; CORRELATE; LDL; Ceramide; Sphingomyelin; Chemerin; Model for end-stage liver disease score; Ascites; Varices; Alcoholic; Hepatitis C
subject: 610 Medizin

description: Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is of particular importance in cholesterol metabolism with high levels contributing to hypercholesterolemia. Cholesterol and sphingolipids are low in patients with liver cirrhosis. Purpose of this study was to find associations of plasma PCSK9 with circulating cholesterol and sphingolipid species and measures of liver disease severity in patients with liver cirrhosis. Methods PCSK9 protein levels were determined by ELISA in systemic vein (SVP), hepatic vein (HVP) and portal vein plasma of patients with mostly alcoholic liver cirrhosis. PCSK9 and LDL-receptor protein expression were analysed in cirrhotic and non-cirrhotic liver tissues. Results Serum PCSK9 was reduced in patients with liver cirrhosis in comparison to non-cirrhotic patients. In liver cirrhosis, plasma PCSK9 was not correlated with Child-Pugh score, Model for End-Stage Liver Disease score, bilirubin or aminotransferases. A negative association of SVP PCSK9 with albumin existed. PCSK9 protein in the liver did not change with fibrosis stage and was even positively correlated with LDL-receptor protein levels. Ascites volume and variceal size were not related to PCSK9 levels. Along the same line, transjugular intrahepatic shunt to lower portal pressure did not affect PCSK9 concentrations in the three blood compartments. Serum cholesterol, sphingomyelin and ceramide levels did not correlate with PCSK9. Stratifying patients by high versus low PCSK9 levels using the median as cut-off, several cholesteryl ester species were even low in the subgroup with high PCSK9 levels. A few sphingomyelin species were also reduced in the patients with PCSK9 levels above the median. PCSK9 is highly expressed in the liver but systemic, portal and hepatic vein levels were similar. PCSK9 was not correlated with the inflammatory proteins C-reactive protein, IL-6, galectin-3, resistin or pentraxin 3. Of note, HVP PCSK9 was positively associated with HVP chemerin and negatively with HVP adiponectin levels. Conclusions In the cohort of patients with liver cirrhosis mostly secondary to alcohol consumption high PCSK9 was associated with low levels of certain cholesteryl ester and sphingomyelin species. Positive correlations of PCSK9 and LDL-receptor protein in the liver of patients with chronic liver injury are consistent with these findings.
Juraheterosmylus antiquatus Wang, Liu, Ren & Shih, 2010, sp. nov.
Creators: name: Wang, Yongjie
name: Liu, Zhiqi
name: Ren, Dong
name: Shih, Chungkun
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Osmylidae
Juraheterosmylus
Juraheterosmylus antiquatus

description: Juraheterosmylus antiquatus sp. nov.
(Figs. 1 A–B, 2A–B)
Diagnosis. Cross-veins r1-rs and outer gradate series edged with fuscous spots.
Description. Head deformed, quadrate; eyes protruded, distinctly dark; antennae not preserved. Prothorax wider than long, quadrate; mesothorax bulging; metathorax short, with full-developed sclerites. Abdomen 10 segmented; first segment reduced, caudal segment approximately pyriform, resembling the ectoproct of extant osmylids.
Forewing 23.4mm long (right forewing and hindwing overlapped, and apex of left forewing not preserved), 7.2mm wide. Membrane with few spots, pterostigma light yellow; nygmata brown, present at the base between Rs and MP; trichosors present in the anterior margin and posterior margin; cross-veins r1-rs and outer gradate series edged with fuscous spots. Venation: costal cross-veins simple, dense close to the apex, with few distal forks; Sc and R1 fused distal; cross-veins r1-rs six branches; Rs originate from R1; Rs with 13 branches, each branch sinuous in the middle, and forming complicate distal forks; cross-veins between Rs branches arranged regularly, forming three rows of gradate series; MP forked close to the separation of MA from Rs, only four cross-veins present between both branches; Cu forked at the wing base, both branches approximately with equal length; CuA with four distal branches, CuP with three distal branches; A1 with four distal branches, its length beyond half of CuP; A2 with two simple branches; A3 simple. Hindwing 22.8mm long (incomplete, as preserved), 7.3mm wide. Membrane resembling the forewing, with few spots; pterostigma light yellow; nygmata not detected due to the poor preservation; trichosors present along the anterior and posterior margin. Venation: costal cross-veins simple, with few distal forks; r1-rs cross-veins five branches; Rs stem with a short, basal additional vein; Rs with 10 branches; Rs region poorly preserved; MP forked close to the wing base, MP with complicated distal forks; Cu forked at wing base, both branches and anal region preserved poorly.
Holotype. CNU-NEU-NN2010201. Specimen consists of a relatively complete body with wings stretched-out, but the right forewing and hindwing are overlapped.
Type locality. Daohugou Village, Shantou Township, Ningcheng County, Inner Mongolia, China.
Type horizon. Jiulongshan Formation, Bathonian–Callovian boundary, Middle Jurassic.
Etymology. The specific name is from the Latin word antiqutus (meaning, old), referring to the oldest record of Protosmylinae.
description: Published as part of Wang, Yongjie, Liu, Zhiqi, Ren, Dong & Shih, Chungkun, 2010, A new genus of Protosmylinae from the Middle Jurassic of China (Neuroptera: Osmylidae), pp. 45-53 in Zootaxa 2480 on pages 48-49, DOI: 10.5281/zenodo.195411
Agrilus alborubronigrus Hespenheide
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus alborubronigrus

description: Agrilus alborubronigrus Hespenheide
GRO, 2 mi N Cacahuamilpa, 19-VII-84, TAMU.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 7, DOI: 10.5281/zenodo.273645
METHODS OF DEVELOPING CREATIVE ABILITIES IN CHORAL CONDUCTING
Creators: name: Kazakov, Odilbek
Publisher: name: Zenodo
Year: 2024

description: This article analyzes effective methods for developing students' creative abilities in the discipline of choral conducting. In particular, the possibilities of forming musical and creative abilities through the use of innovative approaches, interactive methods, and technologies in the pedagogical process are considered. The study highlights the importance of using new methodological methods in the development of musical taste, rhythmic sense, and aesthetic sensitivity in teaching choral conducting. In addition, the methodological aspects of strengthening coherence and creative cooperation in working with choral groups are analyzed.
Juraheterosmylus astictus Wang, Liu, Ren & Shih, 2010, sp. nov.
Creators: name: Wang, Yongjie
name: Liu, Zhiqi
name: Ren, Dong
name: Shih, Chungkun
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Osmylidae
Juraheterosmylus
Juraheterosmylus astictus

description: Juraheterosmylus astictus sp. nov.
(Figs. 1 C–D, 3A–B)
Diagnosis. Forewing relatively small (the length not beyond 20mm), without spots except the pterostigma.
Description. Head not preserved. Prothorax only partly preserved; mesothorax broad, with fullydeveloped sclerites; metathorax and abdomen preserved poorly.
Forewing 19.8mm long, 6.8mm wide (incomplete). Membrane hyaline, without any spots; pterostigma pale yellow; nygmata not detected for poor preservation. Venation: costal cross-veins simple, with few distal forks; r1-rs cross-veins six branches, with the edged spots; Rs with 12 branches, each branch slight sinuous in middle; cross-veins between Rs branches arranged regularly, forming four rows of gradate series; MP forked beyond the separation of MA from Rs, each branch with complicated distal forks; Cu forked at the wing base; CuA long, with some distal pectinate branches, CuP shorter than CuA, also forming some pectinate branches; anal region not preserved. Hindwing poorly preserved. Membrane resembling the forewing, colorless. Costal region narrow, costal cross-veins simple; Rs branches more than 10, each branch with complicated distal forks; cross-veins between Rs branches arranged regularly, forming two rows of gradate series.
Holotype. CNU-NEU-NN2010202. Specimen consists of an incomplete body with wings stretched-out, but wings are poorly preserved.
Type locality. Daohugou Village, Shantou Township, Ningcheng County, Inner Mongolia, China.
Type horizon. Jiulongshan Formation, Bathonian–Callovian boundary, Middle Jurassic.
Etymology. The specific name is from the Latin word astictus (meaning, immaculate), referring to the immaculate forewing of new species.
description: Published as part of Wang, Yongjie, Liu, Zhiqi, Ren, Dong & Shih, Chungkun, 2010, A new genus of Protosmylinae from the Middle Jurassic of China (Neuroptera: Osmylidae), pp. 45-53 in Zootaxa 2480 on page 49, DOI: 10.5281/zenodo.195411
Epidemiology, Treatment, and Outcomes of Juvenile Idiopathic Arthritis-Associated Uveitis: A Multi-Institutional Study in Taiwan
Creators: name: Wu, Po-Yi
name: Kang, Eugene Yu-Chuan
name: Chen, Wei-Dar
name: Chiang, Wei-Yu
name: Wu, Cheng-Hsiu
name: Wu, Chao-Yi
name: Chen, Kuan-Jen
name: Wu, Wei-Chi
name: Chou, Hung-Da
name: Chao, An-Ning
name: Hwang, Yih-Shiou
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: To assess the epidemiology, treatment, and outcomes of juvenile idiopathic arthritis (JIA)–associated uveitis (JIA-U) in Taiwan. Retrospective, multicenter database. Totally, 44 (6.1%) of the 722 JIA patients had uveitis. The mean ages of JIA and JIA-U diagnosis were 10.7 and 11.1 years, respectively. JIA-U patients had more antinuclear antibody presence. Among JIA-U patients, 25 (56.8%) were male, 11 (25.0%) experienced any ocular complication, and 8 (18.2%) received ocular surgery. Inactivity lasting ≥6 months was achieved in 17 (38.6%) patients; however, 11 (25.0%) of those experienced reactivation with a mean of 624.7 days after achieving inactivity. Female had more ocular complications and surgeries. Late age at JIA-U diagnosis and male predominance were distinctive in Taiwan. For patients with inactivity lasting ≥ 6 months was achieved, they still required close follow-up due to the high reactivation rate within 2 years. Female had poorer ocular outcomes.
Mastering Market Research in 2025: Empowering Startups with Expert Insights
Creators: name: Mirmiran, Seyed Farzad
Publisher: name: Zenodo
Year: 2024

description: In the fast-paced business landscape of 2025, market research has become an indispensable tool for startups seeking to gain a competitive edge. This article explores the evolving importance of market research and how expertly crafted insights can drive strategic decisions. Highlighting the expertise of Seyed Farzad Mirmiran, the piece demonstrates how his tailored market research services equip startups with actionable data, enabling them to thrive in dynamic markets.