cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A finite state machine approach to nano-satellite SW design: the HERMES case study
Creators: name:  MARGHERITA PICCININ
name:   ANDREA BRANDONISIO
name:   ANDREA COLAGROSSI
name:   GIOVANNI ZANOTTI
name:   STEFANO SILVESTRINI
name:   MICHELE LAVAGNA
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: ON-BOARD SOFTWARE
FINITE STATE MACHINE
NANO-SATELLITE SOFTWARE DESIGN
SOFTWARE VERIFICATION

description: In recent years, the number of launched small satellites, has exponentially grown, thanks to their low cost and modularity. Nevertheless, the software of such platforms still requires remarkable mission-specific tailoring efforts. In this paper, a linear, flexible and modular Finite State Machine (FSM) approach for nanosatellites software design is proposed, capable of being easily tailored to the specific mission and tuned according to variations of requirements and functionalities. The proposed FSM structure is composed of three major macro-modes, offering a time-driven mode and a scheduled mode for nominal operations, with a cyclic and basic safe mode, potentially applicable to every generic nano-satellite mission. The presented method has been used for the SW design of the HERMES mission, a 6 CubeSats constellation financed by Italian Ministry of University and Research (MUR), the Italian Space Agency (ASI) and the European Community (EC). HERMES FSM is presented in the paper, as case study for the method application.
PTB-Publica
Creators: name: Physikalisch-Technische Bundesanstalt (PTB )
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB )
Year: 2015
Subjects: PTB-Publica
PTB-Publica_Pro
PTB-Publica_multi

description: Die Datenbank PTB-Publica dokumentiert die Veröffentlichungen von PTB-Angehörigen, die in Berichten, Büchern, Hochschulschriften, Konferenzbänden und Zeitschriften bereits erschienen oder vom Verlag zur baldigen Veröffentlichung angenommen sind. Der Hauptteil des Datenbestandes beginnt mit dem Erscheinungsjahr 1999. Alle Datensätze sind in dokumentarisch relevante Felder strukturiert.
(100617) Fanny Emily Rose Mardon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Proper Protein Glycosylation Promotes Mitogen-Activated Protein Kinase Signal Fidelity
Creators: name: Dohlman, Henrik G.
name: Nagiec, Michal J.
name: Lien, Evan C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ability of cells to sense and respond appropriately to changing environmental conditions is often mediated by signal transduction pathways that employ mitogen-activated protein kinases (MAPKs). In the yeast Saccharomyces cerevisiae, the high osmolarity glycerol (HOG) and the filamentous growth (FG) pathways are activated following hyperosmotic stress and nutrient deprivation, respectively. Whereas the HOG pathway requires the MAPK Hog1, the FG pathway employs the MAPK Kss1. We conducted a comprehensive screen of nearly 5,000 gene deletion strains for mutants that exhibit inappropriate cross-talk between the HOG and FG pathways. We identified two novel mutants, mnn10Δ and mnn11Δ, that allow activation of Kss1 under conditions that normally stimulate Hog1. MNN10 and MNN11 encode mannosyltransferases that are part of the N-glycosylation machinery within the Golgi apparatus; deletion of either gene results in N-glycosylated proteins that have shorter mannan chains. Deletion of the cell surface mucin Msb2 suppressed the mnn11Δ phenotype, while mutation of a single glycosylation site within Msb2 was sufficient to confer inappropriate activation of Kss1 by salt stress. These findings reveal new components of the N-glycosylation machinery needed to ensure MAPK signaling fidelity.
Motivationale Faktoren der Rauchentwöhnung bei Clusterkopfschmerzpatienten
Creators: name: Lenz, Esra
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 610 Medical sciences Medicine

description: Ziel dieser Pilotstudie war es, erstmalig Faktoren zu erfassen, Zusammenhänge zu ermitteln und Daten zu sammeln, die helfen könnten, das schwer betroffene Patientenklientel der Clusterkopfschmerzpatienten erfolgreich zu einem Rauchverzicht zu motivieren, um die Akut-Therapie mit den äußerst wirkungsvollen Triptanen langfristig zu sichern. Die Daten sollen die Grundlage legen, um spätere Interventionen zur Rauchentwöhnung fundiert und effektiv zu gestalten. Es wurden außerdem psychiatrische Komorbiditäten erfasst.
BioNetGen 2.2: Advances in Rule-Based Modeling
Creators: name: Harris, Leonard A.
name: Hogg, Justin S.
name: Tapia, Jose-Juan
name: Sekar, John A. P.
name: Gupta, Sanjana A.
name: Korsunsky, Ilya
name: Arora, Arshi
name: Barua, Dipak
name: Sheehan, Robert P.
name: Faeder, James R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: BioNetGen is an open-source software package for rule-based modeling of complex biochemical systems. Version 2.2 of the software introduces numerous new features for both model specification and simulation. Here, we report on these additions, discussing how they facilitate the construction, simulation, and analysis of larger and more complex models than previously possible.
description: 3 pages, 1 figure, 1 supplementary text file. Supplementary text includes a brief discussion of the RK-PLA along with a performance analysis, two tables listing all new actions/arguments added in BioNetGen 2.2, and the "BioNetGen Quick Reference Guide". Accepted for publication in Bioinformatics
title:  The Origins of the Department of Defense Recommendation to Cross the 38th Parallel During the Korean War
Creators: name: Kirkbride, Wayne A.
Publisher: name: Old Dominion University Libraries
Year: 1991

description: This thesis considers the reasons the Department of Defense (DOD) developed its recommendation concerning the U.S. involvement in the Korean War. The United states initially committed its forces to restore the status quo antebellum. However, by 31 July 1950, the DOD recommended that a free, unified, and representative Korea should be the policy object of the war and that the occupation of all of Korea and the defeat of the North Korean armed forces north and south of the 38th Parallel should be the military objectives.

Several factors contributed to the recommendation of a change in policy and strategy. A different situation in Korea in June and July 1950 from that assumed in the post-World War II environment, the incremental nature of the decisions committing U.S. forces, the influence of General MacArthur, and the focus of the Joint Chiefs of Staff caused the DOD to recommend a policy and implementing strategy inconsistent with the policy object of June 1950.
Role of Context in RNA Structure: Flanking Sequences Reconfigure CAG Motif Folding in Huntingtin Exon 1 Transcripts
Creators: name: Weeks, Kevin M.
name: Busan, Steven
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The length of the CAG repeat region in the huntingtin messenger RNA is predictive of Huntington’s disease. Structural studies of CAG repeat-containing RNAs suggest that these sequences form simple hairpin structures; however, in the context of the full-length huntingtin mRNA, CAG repeats may form complex structures that could be targeted for therapeutic intervention. We examined the structures of transcripts spanning the first exon of the huntingtin mRNA with both healthy and disease-prone repeat lengths. In transcripts with 17 to 70 repeats, the CAG sequences base paired extensively with bases in the 5′ UTR and with a conserved region downstream of the CCG repeat region. In huntingtin transcripts with healthy numbers of repeats, the previously observed CAG hairpin was either absent or short. In contrast, in transcripts with disease-associated numbers of repeats, a CAG hairpin was present and extended from a three-helix junction. Our findings demonstrate the profound importance of sequence context in RNA folding and identify specific structural differences between healthy and disease-inducing huntingtin alleles that may be targets for therapeutic intervention.
Smart district heating and electrification
Creators: name: Østergaard, Poul Alberg
name: Lund, Henrik
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2017

description: District heating systems are prevailing in parts of Northern Europe and this editorial introduces work on the optimisation of such systems in Denmark, Britain and Norway. Focus of two of the articles are on low temperature systems. This is either directly through lowering the forward temperature and analysing system consequences and optimal forward temperatures as in the work of Lund et al. – or it is by the use of the return pipe water for heating in district heating system functioning at relatively high temperature levels, as in the work by Ianakiev on Nottingham. Analyses by Trømborg et al. probe into future Norwegian electricity market prices and their effects on the operation of district heating storage and electric boilers. Finally, Ogundari et al. compare photo voltaic systems to diesel systems in standalone systems for Abuja, Nigeria.
description: International Journal of Sustainable Energy Planning and Management, Vol 12 (2017)
Statistical Analysis of SHAPE-Directed RNA Secondary Structure Modeling
Creators: name: Ding, Feng
name: Dokholyan, Nikolay V.
name: Weeks, Kevin M.
name: Ramachandran, Srinivas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ability to predict RNA secondary structure is fundamental for understanding and manipulating RNA function. The structural information obtained from selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) experiments greatly improves the accuracy of RNA secondary structure prediction. Recently, Das and colleagues [Kladwang et al., Biochemistry 50:8049 (2011)] proposed a “bootstrapping” approach to estimate the variance and helix-by-helix confidence levels of predicted secondary structures based on resampling (randomizing and summing) the measured SHAPE data. We show that the specific resampling approach described by Kladwang et al. introduces systematic errors and underestimates confidence in secondary structure prediction using SHAPE data. Instead, a leave-data-out jackknife approach better estimates the influence of a given experimental dataset on SHAPE-directed secondary structure modeling. Even when 35% of the data were left out in the jackknife approach, the confidence levels of SHAPE-directed secondary structure prediction were significantly higher than those calculated by Das and colleagues using bootstrapping. Helix confidence levels were thus significantly underestimated in the recent study, and resampling approach implemented by Kladwang et al. is not an appropriate metric for assigning confidences in SHAPE-directed secondary structure modeling.
The O(N)-flavoured replica twist defect
Creators: name: Rousu, Alexander Söderberg
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Replica twist defects are of codimension two and enter in quantum information when finding the Rényi entropy. In particular, they generate n replicas of the bulk conformal field theory. We study the monodromy of such defect and learn how a global O(N)-symmetry is broken. By applying the equation of motion to the bulk-defect operator-product expansion we are able to extract the anomalous dimension of defect-local fields.
description: 11 pages, 0 figues
null Geschichte der Klinik Waldeck von der Tuberkulose-Heilstätte zur Fachklinik für Medizinische Rehabilitation
Creators: name: Dethloff, Henry
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine
subject: 900 History

description: Die Arbeit beschreibt die Klinikentwicklung von der Tbc-Heilstätte zur Fachklinik für Rehabilitation. Sie beginnt mit der Betrachtung der Tuberkulose-Situation in Deutschland in der 2. Hälfte des 19. Jahrhunderts und führt über die Gründung der Heilstätte 1911, der Situation der Heilstätte während des I. Weltkrieges, Inflation, Weimarer Republik, Nationalsozialismus und II. Weltkrieg, Nachkriegszeit, DDR-Zeit, dem Rückgang der Tbc, der fachlichen Neuorientierung zur Neurologischen Rehabilitation, dem Übergang vom Sozialismus zur Marktwirtschaft und der weiteren Profilierung bis zum Jahr 2018.
Comparison of Low-temperature District Heating Concepts in a Long-Term Energy System Perspective
Creators: name: Lund, Rasmus
name: Østergaard, Dorte Skaarup
name: Yang, Xiaochen
name: Mathiesen, Brian Vad
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2017

description: District heating systems are important components in an energy efficient heat supply. With increasing amounts of renewable energy, the foundation for district heating is changing and the approach to its planning will have to change. Reduced temperatures of district heating are proposed as a solution to adapt it to future renewable energy systems. This study compares three alternative concepts for district heating temperature level: Low temperature (55/25 oC), Ultra-low temperature with electric boosting (45/25 oC), and Ultra-low temperature with heat pump boosting (35/20 oC) taking into account the grid losses, production efficiencies and building requirements. The scenarios are modelled and analysed in the analysis tool EnergyPLAN and compared on primary energy supply and socioeconomic costs. The results show that the low temperature solution (55/25 oC) has the lowest costs, reducing the total costs by about 100 M€/year in 2050.
description: International Journal of Sustainable Energy Planning and Management, Vol 12 (2017)
Interactive optimization of fluidic injection for single expansion ramp nozzle based on a modified autoencoder
Creators: name:  YUNJIA YANG
name:   JIAZHE LI
name:   RUNZE LI
name:   YUFEI ZHANG
name:   HAIXIN CHEN
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: MACHINE LEARNING
SINGLE EXPANSION RAMP NOZZLE
FLUIDIC INJECTION
THRUST OPTIMIZATION

description: The single expansion ramp nozzle often experiences poor thrust performance at overexpansion conditions. Fluidic injection presents a promising solution to mitigate this issue, although there lacks an effective method to determine injection parameters under varying nozzle operating conditions. This paper presents a novel residual autoencoder surrogate model to fast calculate the pressure and temperature profiles on nozzle surfaces. Considering the characteristics of the nozzle flowfield, the model is designed to predict the difference between the profiles with and without the injection. This approach boosts the model\'s predictive accuracy by 20% and enhances its transferability. Furthermore, the gradient-based optimization algorithm is applied to the model to discern optimal injection parameters under eleven distinct nozzle operating conditions whose nozzle pressure ratios range from 12 to 40. The results indicate a successful increase in average thrust coefficients by 0.76%, demonstrating the effectiveness of the proposed approach.
title: Web-дизайн: основы верстки сайтов
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2023

description: В учебном пособии представлен теоретический материал и практические задания, касающиеся введения в web-технологии, основ HTML, CSS и верстки сайтов. Издание включает также методические рекомендации по выполнению практических работ, перечень вопросов для самопроверки, список тем для углубленного изучения, задание для самостоятельного выполнения проектов. Учебное пособие подготовлено в соответствии с требованиями, предъявляемыми к изучению дисциплин «Web-дизайн», «Основы web-дизайна», и предназначено для студентов, обучающихся по укрупненной группе специальностей среднего профессионального образования 09.00.00 «Информатика и вычислительная техника».
Persistent and occasional: searching for the variable population of the ZTF/4MOST sky using ZTF data release 11
Creators: name: Sánchez-Sáez, P.
name: Arredondo, J.
name: Bayo, A.
name: Arévalo, P.
name: Bauer, F. E.
name: Cabrera-Vives, G.
name: Catelan, M.
name: Coppi, P.
name: Estévez, P. A.
name: Förster, F.
name: Hernández-García, L.
name: Huijse, P.
name: Kurtev, R.
name: Lira, P.
name: Arancibia, A. M. Muñoz
name: Pignata, G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a variability, color and morphology based classifier, designed to identify transients, persistently variable, and non-variable sources, from the Zwicky Transient Facility (ZTF) Data Release 11 (DR11) light curves of extended and point sources. The main motivation to develop this model was to identify active galactic nuclei (AGN) at different redshift ranges to be observed by the 4MOST ChANGES project. Still, it serves as a more general time-domain astronomy study. The model uses nine colors computed from CatWISE and PS1, a morphology score from PS1, and 61 single-band variability features computed from the ZTF DR11 g and r light curves. We trained two versions of the model, one for each ZTF band. We used a hierarchical local classifier per parent node approach, where each node was composed of a balanced random forest model. We adopted a 17-class taxonomy, including non-variable stars and galaxies, three transient classes, five classes of stochastic variables, and seven classes of periodic variables. The macro averaged precision, recall and F1-score are 0.61, 0.75, and 0.62 for the g-band model, and 0.60, 0.74, and 0.61, for the r-band model. When grouping the four AGN classes into one single class, its precision, recall, and F1-score are 1.00, 0.95, and 0.97, respectively, for both the g and r bands. We applied the model to all the sources in the ZTF/4MOST overlapping sky, avoiding ZTF fields covering the Galactic bulge, including 86,576,577 light curves in the g-band and 140,409,824 in the r-band. Only 0.73\% of the g-band light curves and 2.62\% of the r-band light curves were classified as stochastic, periodic, or transient with high probability ($P_{init}\geq0.9$). We found that, in general, more reliable results are obtained when using the g-band model. Using the latter, we identified 384,242 AGN candidates, 287,156 of which have $P_{init}\geq0.9$.
description: Accepted for publication in Astronomy & Astrophysics. Abstract shortened for arXiv. Tables containing the classifications and features for the ZTF g and r bands, and the labeled sets will be available at CDS. Individual catalogs per class and band, as well as the labeled set catalogs, can be downloaded at Zenodo DOI:10.5281/zenodo.7826045
Doppler Imaging of LQ Hya for 1998-2002
Creators: name: Cole, E. M.
name: Hackman, T.
name: Käpylä, M. J.
name: Ilyin, I.
name: Kochukhov, O.
name: Piskunov, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study the spot distribution on the surface of LQ~Hya during the observing seasons October 1998 -- November 2002. We look for persistent active longitudes, trends in the level of spot activity and compare to photometric data, specifically to the derived time epochs of the lightcurve minima. We apply the Doppler Imaging technique on photospheric spectral lines using an inversion code to retrieve images of the surface temperature. We present new temperature maps using multiple spectral lines for a total of 7 seasons. We calculate spot coverage fractions from each map, and as a result we find a general trend that is interpreted to be an indication of a spot cycle. There is a minimum during the observing season of March 1999. After this the activity increases until November 2000, followed by a general decrease in activity again. We find no evidence for active longitudes persisting over multiple observing seasons. The spot activity appears to be concentrated to two latitude regions. The high latitude spots are particularly strong when the spot coverage is at a maximum. Using the currently accepted rotation period, we find spot structures to show a trend in the phase-time plot, indicative of a need for a longer period. We conclude that the long-term activity of LQ~Hya is more chaotic than that of some magnetically active binary stars analyzed with similar methods, but still with clear indications of an activity cycle.
description: 9 pages, 10 figures
(100615) William Francis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Innovative system for delivery of low temperature district heating
Creators: name: Ianakiev, Anton Ivanov
name: Cui, Jia Michelle
name: Garbett, Steve
name: Filer, Andrew
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2017

description: An innovative Low Temperature District Heating (LTDH) local network is developed in Nottingham, supported by REMOURBAN project, part of the H2020 Smart City and Community Lighthouse scheme. It was proposed that a branch emanating from the return pipe of the of the existing district heating system in Nottingham would be created to use low temperature heating for the first time in UK. The development is aimed to extract wasted (unused) heat from existing district heating system and make it more efficient and profitable. Four maisonette blocks of 94 low-raised flats, at Nottingham demo site of the REMOURBAN project will be connected to this new LTDH system. The scheme will provide a primary supply of heat and hot water at approximately 50oC to 60oC. Innovated solutions have been put forward to overcome certain barriers, such as legionella related risks and peak loads during extreme heating seasons and occasional maintenance.
description: International Journal of Sustainable Energy Planning and Management, Vol 12 (2017)
(100613) Georgiana Eleanor Francis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Tribody: Robust Self-Assembled Trimeric Targeting Ligands with High Stability and Significantly Improved Target-Binding Strength
Creators: name: Kim, Sang Kyun
name: Liu, Rihe
name: Kim, Dongwook
name: Alexander Valencia, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The C-terminal coiled-coil region of mouse and human cartilage matrix protein (CMP) self-assembles into a parallel trimeric complex. Here, we report a general strategy for the development of highly stable trimeric targeting ligands (tribody), against epidermal growth factor receptor (EGFR) and prostate-membrane specific antigen (PSMA) as examples, by fusing a specific target-binding moiety with a trimerization domain derived from CMP. The resulting fusion proteins can efficiently self-assemble into a well-defined parallel homotrimer with high stability. Surface plasmon resonance (SPR) analysis of the trimeric targeting ligands demonstrated significantly enhanced target binding strength compared with the corresponding monomers. Cellular binding studies confirmed that the trimeric targeting ligands have superior binding strength towards their respective receptors. Significantly, EGFR-binding tribody was considerably accumulated in tumor in xenograft mice bearing EGFR positive tumors, indicating its effective cancer targeting feature under in vivo conditions. Our results demonstrate that CMP-based self-assembly of tribody can be a general strategy for the facile and robust generation of trivalent targeting ligands for a wide variety of in vitro and in vivo applications.
A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry
Creators: name: Jorgenson, James W.
name: Stafford, Darrel W.
name: Parker, Christine H.
name: Engen, John R.
name: Rand, Kasper D.
name: Morgan, Christopher R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Gamma (γ)-glutamyl carboxylase (GGCX) is an integral membrane protein responsible for the post-translational catalytic conversion of select glutamic acid (Glu) residues to γ-carboxy glutamic acid (Gla) in vitamin K-dependent (VKD) proteins. Understanding the mechanism of carboxylation and the role of GGCX in the vitamin K cycle is of biological interest in the development of therapeutics for blood coagulation disorders. Historically, biophysical investigations and structural characterizations of GGCX have been limited due to complexities involving the availability of an appropriate model membrane system. In previous work, a hydrogen exchange mass spectrometry (HX MS) platform was developed to study the structural configuration of GGCX in a near-native nanodisc phospholipid environment. Here we have applied the nanodisc–HX MS approach to characterize specific domains of GGCX that exhibit structural rearrangements upon binding the high-affinity consensus propeptide (pCon; AVFLSREQANQVLQRRRR). pCon binding was shown to be specific for monomeric GGCX-nanodiscs and promoted enhanced structural stability to the nanodisc-integrated complex while maintaining catalytic activity in the presence of carboxylation co-substrates. Noteworthy modifications in HX of GGCX were prominently observed in GGCX peptides 491–507 and 395–401 upon pCon association, consistent with regions previously identified as sites for propeptide and glutamate binding. Several additional protein regions exhibited minor gains in solvent protection upon propeptide incorporation, providing evidence for a structural reorientation of the GGCX complex in association with VKD carboxylation. The results herein demonstrate that nanodisc–HX MS can be utilized to study molecular interactions of membrane-bound enzymes in the absence of a complete three-dimensional structure and to map dynamic rearrangements induced upon ligand binding.
Does Topology Drive Fiber Polymerization?
Creators: name: Lord, Susan T.
name: Powierza, Camilla
name: Huang, Lihong
name: Hsiao, Joe Ping Lin
name: Taylor, Russell M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We have developed new procedures to examine the early steps in fibrin polymerization. First, we isolated fibrinogen monomers from plasma fibrinogen by gel filtration. Polymerization of fibrinogen monomers differed from that of plasma fibrinogen. The formation of protofibrils was slower and the transformation of protofibrils to fibers faster for the fibrinogen monomers. Second, we used formaldehyde to terminate the polymerization reactions. The formaldehyde-fixed products obtained at each time point were examined by dynamic light scattering and transmission electron microscopy (TEM). The data showed the formaldehyde-fixed products were stable and representative of the reaction intermediates. TEM images showed monomers, short oligomers, protofibrils, and thin fibers. The amount and length of these species varied with time. Short oligomers were less than 5% of the molecules at all times. Third, we developed models that recapitulate the TEM images. Fibrin monomer models were assembled into protofibrils, and protofibrils were assembled into two-strand fibers using Chimera software. Monomers were based on fibrinogen crystal structures, and the end-to-end interactions between monomers were based on D-dimer crystal structures. Protofibrils assembled from S-shaped monomers through asymmetric D:D interactions were ordered helical structures. Fibers were modeled by duplicating a protofibril and rotating the duplicate 120° around its long axis. No specific interactions were presumed. The two protofibrils simply twisted around one another to form a fiber. This model suggests that the conformation of the protofibril per se promotes the assembly into fibers. These findings introduce a novel mechanism for fibrin assembly that may be relevant to other biopolymers.
Wechselwirkung der Kollagen-Induzierten Arthritis und der Parodontitis im Mausmodell
Creators: name: Buschhart, Anna-Lena
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die rheumatoide Arthritis ist eine chronisch entzündliche Autoimmunerkrankung der Gelenke, welche zu Knorpel- und Knochenschäden sowie zu Einschränkungen der Bewegungsfähigkeit und Reduzierung der Lebensqualität führt. Die Parodontitis ist eine Entzündung des Zahnhalteapparates, die eine Zerstörung des Alveolarknochens und Zahnverluste bewirkt. In der vorliegenden Arbeit wurde ein Tiermodell genutzt, um zu analysieren, welche Auswirkungen beide Erkrankungen aufeinander haben.
(100614) Sarah Francis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate
Creators: name: Cui, Wenjun
name: Wan, Yiqian
name: Ke, Hengming
name: Wang, Yousheng
name: Robinson, Howard
name: Huang, Manna
name: Tian, Yuanyuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cyclic nucleotide phosphodiesterases (PDEs) decompose second messengers cAMP and cGMP that play critical roles in many physiological processes. PDE1 of Saccharomyces cerevisiae has been subcloned and expressed in Escherichia coli. Recombinant yPDE1 has a KM of 110 μM and a kcat of 16.9 s–1 for cAMP and a KM of 105 μM and a kcat of 11.8 s–1 for cGMP. Thus, the specificity constant (kcat/KMcAMP)/(kcat/KMcGMP) of 1.4 indicates a dual specificity of yPDE1 for hydrolysis of both cAMP and cGMP. The crystal structures of unliganded yPDE1 and its complex with GMP at 1.31 Å resolution reveal a new structural folding that is different from those of human PDEs but is partially similar to that of some other metalloenzymes such as metallo-β-lactamase. In spite of their different structures and divalent metals, yPDE1 and human PDEs may share a common mechanism for hydrolysis of cAMP and cGMP.
Reconstruction within the Zeldovich approximation
Creators: name: White, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Zeldovich approximation, 1st order Lagrangian perturbation theory, provides a good description of the clustering of matter and galaxies on large scales. The acoustic feature in the large-scale correlation function of galaxies imprinted by sound waves in the early Universe has been successfully used as a `standard ruler' to constrain the expansion history of the Universe. The standard ruler can be improved if a process known as density field reconstruction is employed. In this paper we develop the Zeldovich formalism to compute the correlation function of biased tracers in both real- and redshift-space using the simplest reconstruction algorithm with a Gaussian kernel and compare to N-body simulations. The model qualitatively describes the effects of reconstruction on the simulations, though its quantitative success depends upon how redshift-space distortions are handled in the reconstruction algorithm.
description: 7 pages, 3 figures, to appear in MNRAS
On the correctness of cosmology from quantum potential
Creators: name: Lashin, E. I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine in detail the cosmology based on quantal (Bohmian) trajectories as suggested in a recent study arXiv:1404.3093[gr-qc]. We disagree with the conclusions regarding predicting the value of the cosmological constant $Λ$ and evading the big bang singularity. Furthermore, we show that the approach of using a quantum corrected Raychaudhuri equation (QRE), as suggested in arXiv:1404.3093[gr-qc], is unsatisfactory, because, essentially, it uses the Raychaudhuri equation, which is a kinematical equation, in order to predict dynamics. In addition, even within this inconsistent framework, the authors have adopted unjustified assumptions and carried out incorrect steps leading to doubtful conclusions.
description: 7 pages (just the same as v1 but the height of pages are altered to make page numbers visible)
Essays on the economics of slavery and serfdom
Creators: name: Willert, Bianca
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 330 Economics

description: This dissertation investigates modern slavery: Essay 1 presents a theoretical matching model of forced labor. It addresses how oppressors recruit their victims and how certain mechanisms affect the extent of exploitation. Essay 2 presents a theoretical model where slaveholders can buy protection from punishment by bribing corrupt inspectors. Bribery is modelled via Nash bargaining. Multiple equilibria and hysteresis are possible. Essay 3 studies empirically how political decision-making, institutional environment and exploitation are interlinked by creating a novel dataset.
Determination of the fragmentation functions from an NLO QCD analysis of the HERMES data on pion multiplicities
Creators: name: Leader, Elliot
name: Sidorov, Alexander V.
name: Stamenov, Dimiter B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: An NLO QCD analysis of the final HERMES data on pion multiplicities is presented and a new set of pion fragmentation functions is extracted from the best fit to the data. We have studied the so-called [x,z] and [Q^2,z] presentations of their data, as given by HERMES, which, in principle, should simply be two different ways of presenting the experimental data. We have based our extraction on an excellent fit to the [Q^2,z] presentation of the data. We also draw attention to what appears to be a problem with the [x,z] presentation of the HERMES data.
description: 12 pages, 7 figures; This updated version corresponds to the paper accepted for publication in Phys. Rev. D
Studying some genes affecting growth traits and milk production in Egyptian Barki sheep breed
Creators: name: Abousoliman, Ibrahim
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 590 Zoological sciences
subject: 630 Agriculture

description: The Barki sheep is an indigenous sheep breed in Egypt that is well adapted to the harsh conditions of semi-arid regions. In this thesis, two genetic approaches, the candidate gene approach and genome-wide SNP analysis, were used to investigate the genetic basis of growth traits and milk performance in a Barki sheep population. Genetic variation has been demonstrated for these traits, which can be used to establish specific breeding programs. Understanding the genetics will provide valuable information that will help improve growth and milk performance traits in the Egyptian Barki sheep breed.
SAMUTER Las huertas de autoconsumo de la Sierra de Huelva
Creators: name: Martín, Miguel García
Publisher: name: Zenodo
Year: 2023
Subjects: SAMUTER, Sistemas agroaolimentarios, Sierra de Huelva

description: La ganadería en extensivo de las Montañas de León: el caso de la Reserva de la Biosfera de Ancares leoneses, forma parte del proyecto SAMUTER (Sistemas Agroalimentarios Multifuncionales y Territorializados) (https://samuter.paisajeterritoriouam.es/). La horticultura de autoconsumo de la Sierra de Huelva es un sistema agro-territorial singular y relativamente marginal en un espacio dominado por los aprovechamientos silvopastoriles extensivos propios de la dehesa. De pequeño tamaño, y diseminadas a lo largo de la Sierra Morena onubense, las huertas suponen un modelo de explotación no comercial, orientadas al abastecimiento alimentario complementario de la población propietaria local, con un ritmo muy estacional (sobre todo estival) y una producción eminentemente hortícola. De hecho, algunos productos, como el tomate, trascienden sus estrictas funciones alimentarias para convertirse en iconos de unas explotaciones agrícolas con importantes valores patrimoniales y socio-culturales. Extensive livestock farming in the Mountains of León: the case of the Ancares Biosphere Reserve in León, is part of the SAMUTER project (Multifunctional and Territorialised Agri-food Systems) (https://samuter.paisajeterritoriouam.es/). Self-consumption horticulture in the Sierra de Huelva is a unique and relatively marginal agro-territorial system in an area dominated by extensive silvopastoral use of the dehesa. Small in size and scattered throughout the Sierra Morena of Huelva, the huertas are a non-commercial model of exploitation, oriented towards the complementary food supply of the local landowning population, with a very seasonal rhythm (especially in summer) and an eminently horticultural production. In fact, some products, such as tomatoes, transcend their strict food functions to become icons of farms with important heritage and socio-cultural values.
Parasite fauna of common freshwater fishes from Mecklenburg-Western Pomerania, Germany
Creators: name: Suthar, Jaydipbhai
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 570 Life science
subject: 590 Zoological sciences

description: The present study was conducted to investigate the parasite fauna of four freshwater fish species (perch, Perca fluviatilis bream, Abramis brama; roach, Rutilus rutilus and rudd, Scardinius erythrophthalmus) from Lake Tollense, Mecklenburg-Western Pomerania (MV) during 2018-2019. In addition, parasitological raw data of similar freshwater fish species from Lake Malchin and Lake Hohen Sprenz were obtained from Pikalov (2017) for analysis and comparison. Finally, we studied the direct transfer of parasites from Lake Tollense into an open raceway flow-through aquaculture system.
Dynamics of MutS–Mismatched DNA Complexes Are Predictive of Their Repair Phenotypes
Creators: name: Qiu, Ruoyi
name: Sass, Lauryn E.
name: Weninger, Keith R.
name: Derocco, Vanessa C.
name: Erie, Dorothy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: MutS recognizes base–base mismatches and base insertions/deletions (IDLs) in newly replicated DNA. Specific interactions between MutS and these errors trigger a cascade of protein–protein interactions that ultimately lead to their repair. The inability to explain why different DNA errors are repaired with widely varying efficiencies in vivo remains an outstanding example of our limited knowledge of this process. Here, we present single-molecule Förster resonance energy transfer measurements of the DNA bending dynamics induced by Thermus aquaticus MutS and the E41A mutant of MutS, which is known to have error specific deficiencies in signaling repair. We compared three DNA mismatches/IDLs (T-bulge, GT, and CC) with repair efficiencies ranging from high to low. We identify three dominant DNA bending states [slightly bent/unbent (U), intermediately bent (I), and significantly bent (B)] and find that the kinetics of interconverting among states varies widely for different complexes. The increased stability of MutS–mismatch/IDL complexes is associated with stabilization of U and lowering of the B to U transition barrier. Destabilization of U is always accompanied by a destabilization of B, supporting the suggestion that B is a “required” precursor to U. Comparison of MutS and MutS-E41A dynamics on GT and the T-bulge suggests that hydrogen bonding to MutS facilitates the changes in base–base hydrogen bonding that are required to achieve the U state, which has been implicated in repair signaling. Taken together with repair propensities, our data suggest that the bending kinetics of MutS–mismatched DNA complexes may control the entry into functional pathways for downstream signaling of repair.
Comparison of Tiltrotor Whirl Flutter Analyses with Gimballed and Hingeless Hub Models
Creators: name:  UI-JIN HWANG
name:   JAE-SANG PARK
name:   MYEONG-KYU LEE
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: TILTROTOR
WHIRL FLUTTER
AEROELASTIC INSTABILITY

description: This study investigates and compares the whirl flutter characteristics of two different hub models, gimballed and hingeless hubs, for a tiltrotor aircraft in cruise flight. This study uses the rotorcraft comprehensive analysis code CAMRAD II to model the proprotor, semi-span wing, and pylon, and analyzes the aeroelastic instability of a tiltrotor system. The proprotor frequency characteristics depend onthe hub type and have influence on the wing-rotor interaction to cause whirl flutter. It is shown that the rotor regressive lag mode frequency is an important system design parameter for a hingeless tiltrotor, whereas the rotor regressive gimbal mode is important for agimballed tiltrotor.
The Way of Water: ALMA resolves H2O emission lines in a strongly lensed dusty star-forming galaxy at z $\sim$ 3.1
Creators: name: Perrotta, F.
name: Giulietti, M.
name: Massardi, M.
name: Gandolfi, G.
name: Ronconi, T.
name: Zanchettin, M. V.
name: D'Amato, Q.
name: Behiri., M.
name: Torsello, M.
name: Gabrielli, F.
name: Boco, L.
name: Galluzzi, V.
name: Lapi, A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report ALMA high-resolution observations of water emission lines $p-{\rm{H_2O}} (2_{02}-1_{11}$), $o-{\rm{H_2O}} (3_{21}-3_{12})$, $p-{\rm{H_2O}} (4_{22}-4_{13})$, in the strongly lensed galaxy HATLASJ113526.2-01460 at redshift z $\sim$ 3.1. From the lensing-reconstructed maps of water emission and line profiles, we infer the general physical properties of the ISM in the molecular clouds where the lines arise. We find that the water vapor lines $o-{\rm{H_2O}} (3_{21}-3_{12})$, $p-{\rm{H_2O}} (4_{22}-4_{13})$ are mainly excited by FIR pumping from dust radiation in a warm and dense environment, with dust temperatures ranging from 70 K to $\sim 100$ K, as suggested by the line ratios. The $p-{\rm{H_2O}} (2_{02}-1_{11})$ line instead, is excited by a complex interplay between FIR pumping and collisional excitation in the dense core of the star-forming region. This scenario is also supported by the detection of the medium-level excitation of CO resulting in the line emission CO (J=8-7). Thanks to the unprecedented high resolution offered by the combination of ALMA capabilities and gravitational lensing, we discern the different phases of the ISM and locate the hot molecular clouds into a physical scale of $\sim$ 500 pc. We discuss the possibility of J1135 hosting an AGN in its accretion phase. Finally, we determine the relation between the water emission lines and the total IR luminosity of J1135, as well as the SFR as a function of water emission intensities, comparing the outcomes to local and high-$z$ galactic samples from the literature.
description: 22 pages, 10 figures, final version to be published in Astrophysical Journal
title: Croatia Joins Europe
Creators: name: Kovač, Nikola
Publisher: name: Old Dominion University Libraries
Year: 2013

description: On 1 July 2013 the Republic of Croatia will officially become the 28th member of the European Union. History of Croatia has always kept it on the brink of Europe. The case study of this enlargement examines the relations between Cr9atia and the European Union since Croatia became independent in 1991. This relation is divided into two eras, one of mutual distancing and the other of mutual rapprochement. The thesis aims to identify the dimensions of Croatian road to the EU membership which differ it from other accessions. Now, in the eve of enlargement both Croatia and the European Union face serious economic, social and political problems which they will have to solve together. The thesis examines these problems and ties them to the policies followed during the accession period. Solutions for current problems are seen in reexamining those policies and remembering the principles both Croatia and the European Union were founded on in order to validate this enlargement.
Tight Risk Bounds for Multi-Class Margin Classifiers
Creators: name: Maximov, Yury
name: Reshetova, Daria
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We consider a problem of risk estimation for large-margin multi-class classifiers. We propose a novel risk bound for the multi-class classification problem. The bound involves the marginal distribution of the classifier and the Rademacher complexity of the hypothesis class. We prove that our bound is tight in the number of classes. Finally, we compare our bound with the related ones and provide a simplified version of the bound for the multi-class classification with kernel based hypotheses.
description: 11 pages