cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Binary Indicant of Myelination using Micropillar Arrays (BIMA)
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Damage to myelin from diseases such as multiple sclerosis (MS) results in the disruption of the nerve signal, damage to the axon, and finally degeneration. In order to effectively treat these devastating conditions, it is essential that we develop novel methodologies and approaches to promote repair. To date, there are no therapies for repair or remyelination in MS and this fact alone illustrates the greatest hope and unmet need for MS patients. Functional screening for small molecules or biologicals that promote remyelination represents a major hurdle to the identification and development of rational therapeutics for MS. Therefore, it is imperative to continue to make technical advances in the development of high-throughput screening platforms that will provide insight into the cell autonomous mechanisms for remyelination. Our recent findings and technical advances with in vitro systems provide us with a unique opportunity to contribute to this unmet need in MS. Recently we implemented a small-scale functional screen using nanofiber technology (Lee et al., 2012) and identified an atypical antipsychotic compound that greatly enhances myelination. As a proof of concept, we have validated our findings using in vitro assays (oligodendrocyte-neuronal cocultures; Rosenberg et al., 2008) and an animal model of demyelination (lysolecithin injury; Chong et al., 2012) and obtained extremely promising results. The major aim of this proposal will be to significantly expand our efforts and develop a high-throughput screening methodology using fabricated micropillar arrays that will allow for the quantification and resolution of the kinetics and extent of myelination. By implementing a dual-fluorescence labeling strategy in oligodendroglial cells, we will attempt to initiate small molecule and biological screens via time-lapse microscopy. We believe that this binary fluorescence myelination assay will impart valuable insight into the identification of compounds and biologicals that may promote development, stability and repair in MS.
A discussion of the potential impacts of climate change on the shorelines of the Northeastern USA
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2007

description: An increase in the rate of sea-level rise and potential changes in storminess represent important components of global climate change that will likely affect the extensive coasts of the Northeastern USA. Raising sea level not only increases the likelihood of coastal flooding, but changes the template for waves and tides t o sculpt the coast, which can lead to land loss orders of magnitude greater than that from direct inundation alone. There is little question that sea-level rise, and in particular an increased rate of rise, will result in permanent losses of coastal land.However, quantitative predictions of these future coastal change remains difficult due in part to the complexity of coastal systems and the influence of infrequent storm events, and is further confounded by coastal science’s insufficient understanding of the behavior of coastal systems over decadal timescales. Recently, dramatic improvements in technology have greatly improved our capabilities to investigate and characterize processes and sedimentary deposits in the coastal zone, allowing us, for the first time, to address some of the over-arching problems involved in shoreline change. Despite advances in many areas of coastal geology, our fundamental understanding of shoreline change has been limited by a lack of a broad and integrated scientific focus, a lack of resources, and a lack of willingness on the part of policymakers who make crucial decisions about human activity along the coast to support basic research in this area.Although quantitative predictions remain constrained, there remains little doubt that the predicted climates changes will have profound effects upon the Northeastern coast.
Deep Sequencing Clinical Analysis Tool for Infectious Disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: High-throughput or "Deep" sequencing allows for the generation of millions of DNA sequences from a single sample, and holds great promise for the diagnosis and characterization of clinical infectious disease. The investigators have developed a bioinformatic pipeline for data analysis; however the analysis remains complex and requires a highly skilled computer bioinformatics specialist. We propose to develop a computer interface for deep sequencing data analysis that will enable a clinical laboratory provider to analyze the data and prepare an interpretation and report that will guide patient treatment.
Evaluating students' green skills through sustainable travel to their mobility destination
Creators: name: European University Foundation
Publisher: name: SET Project Consortium
Year: 2024
Subjects: Erasmus+
Green Erasmus
Sustainable Mobility
Sustainable Erasmus+ Travel

description: During the EAIE 2024 conference in Toulouse in September, the poster "Elevating students' green skills through sustainable travel" won the best poster award. Inspired by the Green Competencies Repository, it provided a visual representation of a student’s sustainable journey to reach and return from their mobility destination. Learn more about the SET project here.
Pterniboydaia Fain 1985
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Pterniboydaia

description: Genus Pterniboydaia Fain, 1985
Pterniboydaia Fain, 1985a: 146.
Type species: Boydaia pternistis Fain, 1955 by original designation.
Diagnosis. Palps with 1 segment. Hypostome with 2 pairs of setae. Propodonotal shield absent. Propodonotal region with 5 pairs of setae (se absent). Hysteronotal region with 5 pairs of setae (h2 absent). Agenital series without setae. Genital series with 2 pairs of setae. Pseudanal series with 1 pair of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–0–1–0, trochanters 1–1–0–0, femora 5–4–3–2, genua 4–4–3–3, tibiae 5–3–2–2. Setae situated in anterior part of tarsi I–IV normally developed.
Remark. The monotypic genus associated with birds of the order Galliformes and recorded in the Afrotropical and Palaearctic regions (Fain 1955a, 1956a, 1962c, 1963d).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 415, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Aproida cribrata Lea 1929
Creators: name: Monteith, Caroline S. Chaboo Vivian E. Sandoval-Gómez Mariana Hopper Geoff B.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Aproida
Aproida cribrata

description: Notes on Aproida cribrata Lea, 1929 (Fig. 1–3)
For 100 years, only the holotype (Fig. 1–3) has been known with data label: National Pk, Q., H. Hacker, Dec., 1921 [QM]. As also suggested by Samuelson (1989) we assume that the type locality is Lamington National Park, one of the earliest National Parks in Queensland. Further, it is known from Queensland Museum records that the collector, Henry Hacker, then insect curator at the Queensland Museum, often visited Lamington via O’Reilly’s Guest House which was the only easy access point at that time (by horseback) to the Park. For this reason, it is assumed that the type locality is near the Guest House from which a second specimen has been recorded in recent times (see below).
Lea (1929: 239) reported A. cribrata as flightless without details or illustrations, but Samuelson (1989: 602– 602) figured the species and determined that flightlessness is due to brachyptery with the wing length reduced and simplified and the metasternum very short and distorted.
Chris Reid, Australian Museum, Sydney, identified a second specimen of A. cribrata (Fig. 12), among chrysomelids received from Roger Kitching’s pyrethrin canopy fogging for insect diversity studies in 1989–1990 (Kitching et al. 1993). This specimen was found at: ‘Green Mountains’, an alternative name for the area around O’Reillys’ Guesthouse (28°13′S; 153°07′E) where the type was taken. The specimen label says: “pyrethrin fogging host ‘H-16-7’, O’Reillys, Jan–Feb 1991, R. Kitching”. Kitching et al. (1993) describe the vegetation as notophyll rainforest. Kitching (pers. comm.) advises that his pyrethrin-spray protocol used two sprays at each place, a low (L) spray below the main canopy and a high (H) one in the main canopy as indicated on the labels. Thus, this A. cribrata specimen was from the main canopy, ~ 20–30 m high at that location. Although details about the host tree or epiphytes are lacking, the site was on the Wishing Tree Track close to O’Reillys’ Guesthouse. It is likely that Henry Hacker obtained the holotype from the same general area. If A. cribrata is a regular canopy dweller, its host may be some epiphytic monocot.
description: Published as part of Monteith, Caroline S. Chaboo Vivian E. Sandoval-Gómez Mariana Hopper Geoff B., 2024, Biology of Aproida balyi Pascoe, 1863 (Coleoptera: Chrysomelidae: Cassidinae: Aproidini) on its host plant, Eustrephus latifolius R. Br. ex Ker-Gawl (Asparagaceae) in Australia, pp. 1-28 in Insecta Mundi 2024 (74) on page 29, DOI: 10.5281/zenodo.14662640
Myodopsylla isidori Weyenbergh 1881
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Ischnopsyllidae
Myodopsylla
Myodopsylla isidori

description: Myodopsylla isidori (Weyenbergh, 1881)
NHM. Argentina—unknown locality. Mammalia—Chiroptera—Vespertilionidae— Myotis albescens. Chile; Argentina—Buenos Aires: Chivilcoy, Monasterio. Catamarca: La Banderita, La Puerta. Córdoba: Capital, Iglesia Catedral. Corrientes. Entre Ríos. Jujuy: Jaire, Tiraxi, Río Las Capillas, and Yala. La Rioja: Sumampa. Neuquén: Ahuca Mahuida. Río Negro: Río Colorado. San Luis: Zapallar. Salta: Pampa Grande, Potrerillos, Río de Los Sauces. Santiago del Estero. Tucumán: Aguas Chiquitas, Arroyo Mista, Dique Escaba, Dique San Ignacio, Parque Provincial El Cochuna, Reserva Provincial Aguas Chiquitas, Reserva Provincial Santa Ana. Mammalia— Chiroptera—Molossidae— Tadarida brasiliensis. Vespertilionidae— Myotis dinelli, Myotis keaysi, Myotis nigricans, Myotis riparius, Myotis sp. Autino et al. (2009).
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 241, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Pterniboydaia pternistis
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Pterniboydaia
Pterniboydaia pternistis

description: Pterniboydaia pternistis (Fain, 1955)
(Fig. 11)
Boydaia pternistis Fain, 1955a: 145, figs. 1–2, 1955b: 694, 1956a: 41, 1956b: 646, 1956c: 31, 32, 1962: 266. Holotype in RMCA, examined.
Neoboydaia (Aureliania) pternistis, Fain 1962c: 266, 1963c: 61.
Neoboydaia pternistis, Kaneko et al. 1977: 163, figs. 2, 3.
Pterniboydaia pternistis, Fain 1985: 146.
Type host: Pternistis afer (Statius Müller) (Galliformes: Phasianidae) from Rwanda.
Diagnosis. Palp tarsus with 4 setae (2 ventral setae Na-type, 2 dorso-apical setae Fa- or Fb-type) and solenidion. Hypostomal setae Ea or Eb-type setae. All idiosomal setae (including coxal setae) Ea- or Ec-type, except sensillae si SC-type.
Hosts and distribution. Galliformes (Phasianidae): Perdix perdix (Linnaeus) from Rwanda (introduced) [Southern Prov., Butare] (Fain 1956a), Pternistis afer (St. Mueller) from Rwanda [Southern Prov., Butare] (Fain 1955a), P. swainsOnii (Smith) from Zambia (Fain 1963d).
Non-African hosts and distribution. Phasianidae: BambusicOla thOracicus (Temminck) from Japan (Kaneko et al. 1977), Perdix perdix perdix (Linnaues) from Belgium (Fain 1962d).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 416, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Myodopsylla wolffsohni subsp. wolffsohni Rothschild 1903
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Ischnopsyllidae
Myodopsylla
Myodopsylla wolffsohni
Myodopsylla wolffsohni wolffsohni (rothschild, 1903)

description: Myodopsylla wolffsohni wolffsohni (Rothschild, 1903)
NHM. Paraguay—Paraguarí: Tacuaras. Mammalia—Chiroptera—Molossidae— Myotis albescens. Brazil; Chile; Mexico; Paraguay; Uruguay; Argentina—Corrientes: Estancia San Juan Poriahú. Entre Ríos: Brazo Largo (Delta del Paraná). Salta: Río El Naranjo. Tucumán: San Miguel de Tucumán. Mammalia—Chiroptera—Molossidae— Eumops perotis. Vespertilionidae— Myotis albescens, Myotis chiloensis. Claps & Autino (2012). Myotis chiloensis is not known to occur in the Argentinean provinces mentioned above. Probably the host was misidentified, and may be Myotis albescens.
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 241, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Additional file 1: of The effectiveness of community-based coordinating interventions in dementia care: a meta-analysis and subgroup analysis of intervention components
Creators: name: Backhouse, Amy
name: Obioha Ukoumunne
name: Richards, David
name: McCabe, Rose
name: Watkins, Ross
name: Dickens, Chris
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Master search strategy â   search deployed in MEDLINE OvidSP database. (DOCX 13Â kb)
Glypturus Stimpson 1866
Creators: name: Sato, Taigi
name: Komai, Tomoyuki
name: Shimizu, Naoto
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Callichiridae
Glypturus

description: Key to extant species of Glypturus Stimpson, 1866
1. Telson posterior margin with a small median spine........................... G. rabalaisae Sakai, 2011 (West Atlantic)
- Telson posterior margin unarmed......................................................................... 2
2. Major cheliped palm lower margin armed with spines or spinules........................................................................................................................ G. ferox n. sp. (Northwest Pacific)
- Major cheliped palm lower margin unarmed................................................................ 3
3. Major cheliped palm lateral and mesial faces and carpus lateral face smooth, without field of granules............................................................................. G. armatus (A. Milne Edwards, 1870) (West Pacific)
- Major cheliped palm lateral and mesial faces and carpus lateral face with fields of granules........................... 4
4. Major cheliped palm mesial face with longitudinal field of granules extending from base of fixed fingers to beyond midlength, lateral face with field of distinct granules adjacent to base of fixed finger....................................................................................................... G. acanthochirus Stimpson, 1866 (West Atlantic)
- Major cheliped palm mesial face with vertical, narrow field of granules proximal to base of fingers, lateral face with field of faint granules adjacent to base of fixed finger........................................................................................... G. laurae (de Saint Laurent in de Vaugelas & de Saint Laurent, 1984) (Red Sea, Singapore)
description: Published as part of Sato, Taigi, Komai, Tomoyuki & Shimizu, Naoto, 2024, Glypturus ferox, a new species of ghost shrimp (Decapoda: Axiidea: Callichiridae) from the Ryukyu Islands, southwestern Japan, pp. 379-397 in Zootaxa 5432 (3) on page 393, DOI: 10.11646/zootaxa.5432.3.3, http://zenodo.org/record/10906511
The Histone H4K20me3 Mark as a Therapeutic Target
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Histone modifications are being intensively investigated as tumor markers and targets for therapy. The histone H4 lysine 20 trimethyl (H4K20me3) mark is consistently downregulated in multiple types of tumors. Low levels of H4K20me3 are associated with poor prognosis for colon and breast cancer. However, whether H4K20me3 actively drives cancer progression, the mechanism by which it promotes tumorigenesis, and the most relevant methyltransferase, remain unknown. We propose to address these knowledge gaps. Our goal is to develop cancer therapy that will reintroduce H4K20me3 into patients and thereby limit tumor growth. We discovered that H4K20me3 is expressed at higher levels in quiescent than proliferating fibroblasts. Our ChIP-Seq data revealed that when fibroblasts enter quiescence, H4K20me3 is deposited at genes important for cell fate commitment. Surprisingly, in quiescent, but not proliferating fibroblasts, H4K20me3 is present not only as a repressive mark at the promoter but also in the gene body, and where it is associated with increased gene expression. Downregulation of a methyltransferase that generates H4K20me3, Suv4-20h2, results in increased cell proliferation and reduced chromatin compaction. Our preliminary data also show high levels of H4K20me3 in quiescent hair follicle stem cells and that these levels decline when hair follicles are actively cycling. We propose to investigate the genomewide pattern of H4K20me3 marks in quiescent mouse hair follicle stem cells, their proliferating progeny, hyperplastic hair follicles, and squamous cell carcinomas that arise when Ras is activated and p53 is inactivated in hair follicle stem cells. Further, to determine the functional role of the Suv4-20h2 enzyme in H4K20me3 deposition, we will monitor tumor develop and perform ChIP-Seq for H4K20me3 in mice with homozygous deletion of Suv4-20h2. Reduced levels of H4K20me3 in tumors represents an exciting opportunity for the development of new therapies that could be effective against multiple tumor types. We anticipate that our experiments will allow us to assess the functional role of H4K20me3 in a stepwise model of cancer progression. The findings will provide insight into the mechanisms through which H4K20me3 loss drives tumorigenesis and whether reactivation of Suv4-20h2 represents a promising approach to anti-cancer therapy.
Speleognathopsis Cooreman 1954
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis

description: Genus Speleognathopsis Cooreman, 1954
Speleognathopsis Cooreman, 1954: 428; Fain 1957: 251.
Type species: Speleognathopsis galli Cooreman, 1954 by original designation.
Diagnosis. Palps with 3 segments. Hypostome with 2 pairs of setae. Propodonotal shield present. Propodonotal region with 6–7 pairs of setae. Hysteronotal region with 6 pairs of setae. Agenital series with 2 pairs of setae. Genital series with 2–3 pairs of setae. Pseudanal series with 1–2 pairs of setae. Setae 1a, 3a present, 4a present or absent. Number of leg setae: coxae 1(2)–0(1)–1–0(1), trochanters 1–1–0–0, femora 5(7)–4–3–2(3, 4), genua 4–4– 3–3, tibiae 5–3–3–3. Setae situated in anterior part of tarsi I–IV normally developed.
Remarks. Species of this genus are associated with birds of the orders Acciptriformes, Charadriifomes, Galliformes, Passeriformes and recorded from Afrotropical, Australian, Oriental, Nearctic, and Neotropical regions (Fain 1955b, 1956a, 1963d, 1964a, 1964b; Cooreman 1954; Fain et al. 1966; Domrow 1969, 1991). The Afrotropical fauna comprises five of the six described species: SpeleOgnathOpsis benOiti Fain, 1955, S. charadricOla (Fain, 1964), S. galli Cooreman, 1954, S. OnychOgnathi (Fain, 1964), and S. wai Fain et al., 1966.
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 417, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Aproida monteithi Samuelson 1989
Creators: name: Monteith, Caroline S. Chaboo Vivian E. Sandoval-Gómez Mariana Hopper Geoff B.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Aproida
Aproida monteithi

description: Notes on Aproida monteithi Samuelson, 1989 (Fig. 4–11, 17)
Known from only the male holotype (Fig. 4–8) and female paratype (Fig. 9–11), in QMBA, collected together and with data as on pictured labels. The type and only known locality (Fig. 14, 17) is Thornton Peak which is the highest point of the Thornton Uplands sector of the Wet Tropics Biogeographic Region of Australia (Bryant and Krosch 2016; Yeates and Monteith 2008), The Thornton Uplands is bordered by the Bloomfield River valley to the north and the Daintree River valley to the south. Thornton Peak has many other insect endemics and a summary of them and history of collecting there, with additional photographs, are given by Theischinger (2019).
Samuelson (1989) described mouthparts and genitalia (Fig. 6–7) from the dissected holotype. The male does not have modifications of the protibia and profemora as seen in A. cribrata and A. balyi. The female allotype was not dissected but he inferred it was female based on differences in the abdominal apex. The antennae have two apical antennomeres cream, contrasting with the dark brown basal articles.
description: Published as part of Monteith, Caroline S. Chaboo Vivian E. Sandoval-Gómez Mariana Hopper Geoff B., 2024, Biology of Aproida balyi Pascoe, 1863 (Coleoptera: Chrysomelidae: Cassidinae: Aproidini) on its host plant, Eustrephus latifolius R. Br. ex Ker-Gawl (Asparagaceae) in Australia, pp. 1-28 in Insecta Mundi 2024 (74) on page 30, DOI: 10.5281/zenodo.14662640
Physical Activity and Diet in Adolescents with Disabilities
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The overall objective of the proposed pilot study is to develop appropriate assessment tools to measure physical activity and dietary intake in adolescent females with disabilities. Evidence suggests that certain lifestyle factors, such as physical activity and nutrition, may be associated with risk of breast cancer. Although a number of studies have focused on these lifestyle factors, this research has not targeted women with disabilities (any impairment that interferes with the ability to carry out activities of daily living ). The development of these tools will lay important groundwork for investigating the influence of lifestyle factors and differences among women with disabilities in the etiology of breast cancer.

 To accomplish this objective, a team of researchers from the scientific disciplines of epidemiology and social/behavioral sciences will use focus groups and interviews to develop assessment tools that measure physical activity and diet in this underserved population. Two school districts in the Southern California area have agreed to participate and provide access to adolescent females with disabilities and their families. A total of 250 subjects will be recruited from the participating districts, along with collaborating teachers and parents. In an awareness of human issues, all subjects will volunteer for participation in the study, be paid an honorarium for their time, and information of individual participants will be kept confidential.
Speleognathopsis benoiti Fain 1955
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis
Speleognathopsis benoiti

description: Speleognathopsis benoiti Fain, 1955
(Fig. 12)
Speleognathopsis benoiti Fain, 1955b: 696, 1956a: 29, figs. 13–16, 1962e: 300, fig. 4, 1963d: 25, fig. 28, 1972: 608, fig. 1, 1985a: 150; 1985b: 254, fig. 22; Domrow 1965: 44; 1966: 210; 1969: 393; McDaniel 1967: 94. Holotype in RMCA, examined.
Type host: Vanellus crassirostris (Hartlaub) (Charadriiformes: Charadriidae) from Rwanda.
Diagnosis. Palp tarsus with 3 setae (2 ventral BNa-type, 1 dorsal BDa- or BDb-type), solenidion absent; palp tibia with 1 seta (BDa-type). Hypostomal setae BNa-type. Propodonotum with 7 pairs of setae, vi doubled (vi1, vi2). Setae ve situated anterior to level of sensillae si. Sensillae SAb-type, other dorsal and ventral (including coxal setae) setae BDa-type. Genital series with 3 pairs of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–1–1–1, femora 7–4–3–4.
Hosts and distribution. Charadriiformes (Charadriidae): Vanellus crassirOstris (Hartlaub) and V. senegallus (Linnaeus) both from Rwanda [Southern Prov., Butare] (Fain 1955b, 1956a).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on pages 417-418, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Sternopsylla distincta subsp. distincta Rothschild 1903
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Ischnopsyllidae
Sternopsylla
Sternopsylla distincta
Sternopsylla distincta distincta (rothschild, 1903)

description: Sternopsylla distincta distincta (Rothschild, 1903)
NHM. Paraguay—Villa Rica. Unknown host.Brazil—Paraná: Curitiba. Mammalia—Chiroptera—Molossidae— Molossus molossus. Brasil; Chile; Ecuador; Paraguay; Argentina—Buenos Aires: Bonifacio. Corrientes. Mendoza. Mammalia—Chiroptera-Molossidae— Tadarida brasiliensis.
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 242, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
A New Gene Regulation Factor, LMO-4, in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The etiology of sporadic breast cancers is multifactorial and is thought to involve stepwise mutations in several known oncogenes (tumor promoting) and tumor suppressor genes. The elucidation of novel pathways involved in regulation of proliferation and differentiation of breast epithelial cells has important implications for pathogenesis, prognosis and the identification of targets for therapeutic agents in breast cancer. We have recently cloned a novel gene regulation co-factor, LMO-4, which exhibits prominent expression in breast epithelial cells. Previously characterized members of this gene family have been shown to be required for normal blood cell differentiation and cause lymphocyte-type tumors. Consistent with a role in proliferation and/or early differentiation, the LMO-4 gene is highly expressed in proliferating epithelial cells of the breast. Data suggests that LMO-4 functions as a component of multiprotein complexes that regulate transcription. We hypothesize that LMO-4 participates in regulation of proliferation and differentiation in normal breast epithelial cells, and this may lead to altered patterns of gene expression that contribute to breast cancer.

 To test this hypothesis, we plan to study in more detail the expression pattern of LMO-4 both during normal breast development and in breast cancers particularly with respect to cellular proliferation and differentiation. We plan to introduce both wild-type (i.e., the normal, non-mutated form) LMO-4 and an artificial LMO-4 repressor in the mammary glands of mice. Using mice that are genetically engineered (transgenic) we will be able to examine the effects of LMO-4 on mammary development, differentiation, and tumor processes. As a final goal, we will use the yeast two-hybrid technology to search for proteins that interact with LMO-4 and work with it in gene regulation. Specifically, we suspect that LMO-4 interacts with previously described transcription factors, either nuclear oncoproteins or tumor suppressors, known to be important for the pathogenesis of breast cancer.

 These experiments should provide insights into how LMO-4 regulates cellular proliferation and differentiation in normal and neoplastic breast.
Additional file 10: of Comprehensive genomic analysis of the CNGC gene family in Brassica oleracea: novel insights into synteny, structures, and transcript profiles
Creators: name: Kaleem Kakar
name: Zarqa Nawaz
name: Kakar, Khadija
name: Essa Ali
name: Abdulwareth Almoneafy
name: Raqeeb Ullah
name: Ren, Xue-Liang
name: Qing-Yao Shu
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Multiple sequence alignment of CNGC-encoded proteins of B. oleracea and B. rapa. Multiple sequence alignment was performed by clustal X2 and viewed by GeneDoc software package. (PDF 1436Â kb)
MOESM2 of Combined genome and transcriptome sequencing to investigate the plant cell wall degrading enzyme system in the thermophilic fungus Malbranchea cinnamomea
Creators: name: HĂźttner, Silvia
name: Nguyen, Thanh
name: Zoraide Granchi
name: Chin-A-Woeng, Thomas
name: AhrĂŠn, Dag
name: Larsbrink, Johan
name: Thanh, Vu
name: Olsson, Lisbeth
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Additional file 2. Scatter plots of the biological replicates of the RNAseq data.
Speleognathopsis charadricola Fain 1964
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis
Speleognathopsis charadricola

description: Speleognahopsis charadricola Fain, 1964
Speleognahopsis charadricola Fain, 1964a: 35, figs. 15–16, 1985a: 150. Holotype in RMCA, examined. Type host: Charadrius pecuarius Temminck (Charadriiformes: Charadriidae) from Central Africa.
Diagnosis. Palp tarsus with 3 setae (2 ventral BNa-type, 1 dorsal BD-type), solenidion absent; palp tibia without setae. Hypostomal setae BNa-type. Propodonotum with 6 pairs of setae. Setae ve situated anterior to level of sensillae si. Sensillae SAa-type, other dorsal and ventral (including coxal setae) setae BDa-type. Genital series with 2 pairs of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–0–1–0, femora 7–4–3–3.
Host and distribution. Charadriiformes (Charadriidae): Charadrius pecuarius Temminck from Central Africa (Fain 1964a).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on pages 418-419, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Inhibitors of the Breast Cancer Her-2/neu Gene
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This research plan involves the development of new drugs for the treatment of human breast cancer. It is well established that human breast cancer is associated with uncontrolled cell growth due to the expression of certain cancer genes. One such gene, called Her-2/neu, is mutated and/or over-expressed in 25-30% of breast tumors. This oncogene makes the cells more responsive to growth factors leading to uncontrolled cell growth. Her-2/neu is present on the cell surface, and drug development is underway, including use of specific antibodies, to block its function. The inherent potential limitations with this approach encouraged us to develop alternate approaches to ‘manage’ Her-2/neu expressing breast cancers.

 Our research plan involves the design and study of small molecules to target and inactivate Her-2/neu. The target in our approach is not the Her-2/neu cell-surface receptor, but rather the gene encoding Her-2/neu in the cell nucleus. Every gene is associated with DNA segments that regulate its expression into RNA/protein. We will ‘attack’ the DNA regulatory part of the Her-2/neu gene by use of novel inhibitory molecules, called ‘pyrrole-imidazole polyamides’. These small molecule inhibitors bind to their gene targets with very high affinity and selectivity. Thus, ideally the inhibition is only at the desired target gene. The net effect is to ‘clog’ the normal mechanism of gene usage by the cell, thus ‘turning-off’ a specific gene. The targeted cell is not killed, but genetically reverted to a normal state. The obstacles to overcome are (i) the specific structure of the inhibitory molecule, (ii) selection of the Her-2/neu target DNA sequence to achieve selectivity, and (iii) determination of the optimal dose to reduce potential toxicity. As a test of the effectiveness of our approach, we will determine whether these compounds will inhibit both the expression of genes that are regulated by estrogen and the expression of the Her-2/neu oncogene itself in human breast cancer cells.

 The identification of such small molecule inhibitors of specific gene expression has the potential to generate a new class of drugs for the treatment of human breast cancer.
Speleognathopsis galli Cooreman 1954
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis
Speleognathopsis galli

description: Speleognathopsis galli Cooreman, 1954
Speleognathopsis galli Cooreman, 1954: 429; Fain 1955a: 144, 1955b: 696, 1956a: 26, 1958b: 177, 1963d: 24, 53, 1985a: 149; Domrow 1969: 392; Talbot 1968: 530, 1969: 582, figs. 1 (right), 2–3; Faccini et al. 1981: 135; Panda et al. 1987: 508, figs. 1–3. Holotype in RBINS, examined.
Type host: Gallus gallus domesticus (Linnaeus) (Galliformes: Phasianidae) from Rwanda.
Diagnosis. Palp tarsus with 3 setae (2 ventral Bf- or Bj-type, 1 dorsal Ba-type), solenidion present; palp tibia with 1 seta (Bd-type). Hypostomal setae Bd-type. Setae ve situated anterior to level of sensillae si. Sensillae SAb-type, other dorsal and ventral (including coxal setae) setae BDa-type. Genital series with 3 pairs of setae. Pseudanal series with 1 pair of setae. Setae 1a, 3a present, 4a absent. Number of leg setae: coxae 1–0–1–0, femora 5–4–3–2.
Hosts and distribution. Galliformes (Phasianidae): Gallus gallus dOmesticus (Linnaeus) from Rwanda [Southern Prov., Butare] (Cooreman 1954; Fain 1956a, 1963d) and Angola [Lunda Norte Prov., Dundo] (present study).
Numididae: Numida meleagris intermedius Neumann from Rwanda [Southern Prov., Akanyaru] (Fain 1956a).
Non-African hosts and distribution. Phasianidae: Gallus gallus dOmesticus (Linnaeus) from Papua New Guinea (Talbot 1969), Brazil (Faccini et al. 1981), and India (Panda et al. 1987).
New material examined. Two females Gallus gallus dOmesticus (Linnaeus) (Galliformes: Phasianidae), ANGOLA: Lunda Norte Prov., Dundo, July 1973, coll. S.M. Jadin; specimens deposited in RBINS.
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 419, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Additional file 2: of The effectiveness of community-based coordinating interventions in dementia care: a meta-analysis and subgroup analysis of intervention components
Creators: name: Backhouse, Amy
name: Obioha Ukoumunne
name: Richards, David
name: McCabe, Rose
name: Watkins, Ross
name: Dickens, Chris
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: All included papers â   outlines the papers 35 papers associated to each of the 14 trials. (DOCX 20Â kb)
Integrin Activation in the Metastasis of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In breast cancer, the most dangerous stage of the disease is when the tumor cells spread (metastasize) to other areas of the body. When this happens, the chance for survival is decreased because tumor invasion can be very widespread. Integrins are proteins on the cell surface that are involved in cellular adhesion functions necessary for attachment and movement. Cells have several integrins on their surface, and the presence and role of specific integins in tumor metastasis is not clear. The focus of our research is on a specific integrin receptor, called avb3. In previous work we have found that it is present at higher levels in breast cancer tumors that are metastatic. We showed direct evidence that avb3 is necessary for the invasion of breast cancer.

 Our research has two objectives. First, we propose to strengthen the observation on the essential role of avb3 in metastasis. For these experiments we will use mutant forms of avb3 and examine the ability of cells to form tumors in mice. Secondly, we will test the hypothesis that the cell adhesion function of avb3 is regulated by an "On/Off switch" that operates within the cell. Our hypothesis is that when avb3 is "on," the cell will bind tightly to its surroundings such that the cell is immobilized. Conversely, when avb3 is "off," the tumor cell can "walk away" and spread to other areas of the body. Normal cells can regulate the "On/Off switch," so that the avb3 function becomes modulated. Thus, tumor cells gain the ability to invade because they can no longer control the "On/Off switch." Our approach will be to (i) develop antibodies to "freeze" the avb3 integrin receptor in a state to prevent metastasis and (ii) study a possible regulatory protein for the "On/Off switch." The regulatory protein is apparently absent in tumor cells, which allows them to spread. We will test this by introducing this regulatory protein into tumor cells to determine whether metastasis is affected.

 These studies will possibly provide new breast cancer therapeutic targets (the "On/Off switch" and its regulators) for designing drugs to halt the spread of breast cancer.
Speleognathopsis onychognathi
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis
Speleognathopsis onychognathi

description: Speleognathopsis onychognathi (Fain, 1964)
Astrida (Astrida) onychognathi Fain, 1964a: 37, figs. 17–21.
Speleognathopsis onychongathi, Fain 1985a: 146. Holotype in RMCA, examined. Type host: Onychognathus walleri elgonensis (Sharpe) (Passeriformes: Sturnidae) from Rwanda.
Diagnosis. Palp tarsus with 3 setae (2 ventral Bd- and BNe-type, 1 dorsal Bb-type), solenidion present; palp tibia without setae. Hypostomal setae Bd-type. Setae ve situated anterior to level of sensillae si. Genital series with 3 pairs of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–0–1–0, femora 7–4–3–3.
Host and distribution. Passeriformes (Sturnidae): OnychOgnathus walleri elgOnensis (Sharpe) from Rwanda [Southern Prov., Butare] (Fain 1964a).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 419, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Chaunoplectella Ijima 1896
Creators: name: Wang, Chunsheng
name: Zhang, Yuan
name: Lu, Bo
name: Wang, Dexiang
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Hexactinellida
Lyssacinosida
Leucopsacidae
Chaunoplectella

description: Genus Chaunoplectella Ijima, 1896
Type species: Chaunoplectella cavernosa Ijima, 1896 (by monotypy)
description: Published as part of Wang, Chunsheng, Zhang, Yuan, Lu, Bo & Wang, Dexiang, 2018, New Hexactinellid Sponge Chaunoplectella megapora sp. nov. (Lyssacinosida: Leucopsacidae) from Clarion-Clipperton Fracture Zone, Eastern Pacific Ocean, pp. 136-142 in Zootaxa 4375 (1) on page 137, DOI: 10.11646/zootaxa.4375.1.8, http://zenodo.org/record/1158217
Sternopsylla distincta subsp. speciosa Johnson 1957
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Ischnopsyllidae
Sternopsylla
Sternopsylla distincta
Sternopsylla distincta speciosa johnson, 1957

description: Sternopsylla distincta speciosa Johnson, 1957
FMNH. Peru—Cuzco: Quince Mil. Mammalia—Chiroptera— Tadarida brasiliensis. Colombia; Paraguay; Peru; Panama; Venezuela; Argentina—Buenos Aires: Estancia San José, Santa Clara del Mar. Catamarca: El Rodeo. Jujuy: Río Tiraxi, San Salvador de Jujuy. Mendoza: Santa Rosa. Salta: Rosario de La Frontera. Tucumán: Dique Escaba, Dique San Ignacio (La Cocha), San Miguel de Tucumán. Mammalia—Chiroptera—Vespertilionidae— Myotis albescens, Myotis sp.; Molossidae— Tadarida brasiliensis, Tadarida sp. Autino et al. (2005).
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 242, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Leptopsylla (L.) segnis Schonherr 1811
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Leptopsyllidae
Leptopsylla
Leptopsylla segnis

description: Leptopsylla (L.) segnis (Schönherr, 1811)
Lost. Unknown. Cosmopolitan. Argentina—Buenos Aires: Puerto. Jujuy. Santa Fe: Rosario. Mammalia-Rodentia- Muridae— Rattus rattus, R. norvegicus.
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 242, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Speleognathopsis wai Fain, Vercammen-Grandjean and Wagner 1966
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Speleognathopsis
Speleognathopsis wai

description: Speleognathopsis wai Fain, Vercammen-Grandjean and Wagner, 1966
Speleognathopsis wai Fain et al., 1966: 115, figs. 1–11; Domrow 1969: 393. Holotype in RMCA, examined. Type host: Rhinoptilus africanus Temminick (Charadriiformes: Glareolidae) from South Africa.
Diagnosis. Palp tarsus with 3 setae (2 ventral BNa-type, 1 dorsal BD-type), solenidion absent; palp tibia with 1 seta (BD-type). Hypostomal setae Bc- or BNa-type. Setae ve situated anterior to level of sensillae si. Genital series with 2 pairs of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–0–1–0, femora 7–4–3–4.
Host and distribution. Charadriiformes (Glareolidae): RhinOptilus africanus Temminck from South Africa [North West Prov., Bloemhof] (Fain et al. 1966).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 419, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
2011 New Jersey energy master plan
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2011

description: New Jersey needs to formulate a vision of what its energy infrastructure will consist of in the first half of the21st century. Informed decision-making requires a rigorous assessment of the program options and goals which are set forth in the 2011 Energy Master Plan. The report includes: background on the Energy Master Plan initiative; an overview of New Jersey's electric industry; an overview of natural gas and other fuels; recent legislative and regulatory initiatives; and the 2011 plan for action, which includes five overarching goals.