cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Continued vigilance – development of an online evaluation tool for assessing preparedness of medical facilities for biological events
Creators: name: Adini, Bruria
name: Verbeek, Luzie
name: Trapp, Susanna
name: Schilling, Stefan
name: Sasse, Julia
name: Pientka, Kathrin
name: Böddinghaus, Boris
name: Schaefer, Helene
name: Schempf, Jörg
name: Brodt, Reinhard
name: Wegner, Christian
name: Lev, Boaz
name: Laor, Daniel
name: Gottschalk, René
name: Biederbick, Walter
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: standard operating procedures
subject: measurable indicators
subject: biological event
subject: evaluation of emergency preparedness
subject: disaster management
subject: 610 Medizin

description: Objective: Effective response to biological events necessitates ongoing evaluation of preparedness. This study was a bilateral German–Israeli collaboration aimed at developing an evaluation tool for assessing preparedness of medical facilities for biological events. Methods: Measurable parameters were identified through a literature review for inclusion in the evaluation tool and disseminated to 228 content experts in two modified Delphi cycles. Focus groups were conducted to identify psychosocial needs of the medical teams. Table-top and functional exercises were implemented to review applicability of the tool. Results: One hundred seventeen experts from Germany and Israel participated in the modified Delphi. Out of 188 parameters that were identified, 183 achieved a consensus of >75% of the content experts. Following comments recommended in the Delphi cycles, and feedback from focus groups and hospital exercises, the final tool consisted of 172 parameters. Median level of importance of each parameter was calculated based on ranking recommended in the Delphi process. Computerized web-based software was developed to calculate scores of preparedness for biological events. Conclusion: Ongoing evaluation means, such as the tool developed in the study, can facilitate the need for a valid and reliable mechanism that may be widely adopted and implemented as quality assurance measures. The tool is based on measurable parameters and indicators that can effectively present strengths and weaknesses in managing a response to a public health threat, and accordingly, steps can be implemented to improve readiness. Adoption of such a tool is an important component of assuring public health and effective emergency management.
Hepatic adverse events associated with anaplastic lymphoma kinase tyrosine kinase inhibitors: a disproportionality analysis based on FAERS database and analysis of drug-gene interaction network
Creators: name: Huo, Yan
name: Ma, Minghua
name: Tian, Weiwei
name: Wang, Fang
name: Liao, Xiaolan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are vital for treating ALK-positive cancers but have been associated with liver injury, necessitating further safety investigation. This study examines hepatic adverse event (AE) signals related to ALK TKIs using the U.S. FDA Adverse Event Reporting System (FAERS) and explores potential mechanisms of liver injury. AE reports from FAERS (Q3 2011 to Q1 2024) related to liver injury were analyzed using the reporting odds ratio (ROR) and multi-item gamma Poisson shrinker (MGPS) methods. Pathway enrichment and drug-gene network analyses were performed to investigate underlying mechanisms. This study identified 2,132 AE reports from the FAERS database linking hepatic AEs to ALK TKIs therapy. Significant signals were detected by ROR and MGPS methods, with common AEs including aminotransferase abnormalities, hyperbilirubinemia, and increased blood alkaline phosphatase, mainly occurring within the first 30 days of treatment. Gene analysis revealed key nodes in the protein-protein interaction (PPI) network, such as PIK3CA, SRC, and PTK2. Enriched KEGG pathways included the MAPK, PI3K-Akt, and Ras signaling. This pharmacovigilance study identifies significant AE signals linking ALK TKIs to liver injury, highlighting potential mechanisms and providing insights for clinical management and patient outcomes.
Messung des sozioökonomischen Status in der KiGGS-Studie
Creators: name: Lampert, Thomas
name: Müters, Stephan
name: Stolzenberg, Heribert
name: Kroll, Lars Eric
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2014
Subjects: subject: Gesundheitssurvey
subject: Gesundheitsmonitoring
subject: Sozioökonomischer Status
subject: Soziale Ungleichheit
subject: Gesundheitliche Ungleichheit
subject: Health monitoring
subject: Social inequality
subject: Health inequality
subject: Health survey
subject: Socioeconomic status
subject: 610 Medizin

description: Der Beitrag beschreibt die Messung des sozioökonomischen Status (SES) in der ersten Folgebefragung der KiGGS-Studie (KiGGS Welle 1), die in den Jahren 2009 bis 2012 durchgeführt wurde. Verwendet wird ein mehrdimensionaler Index, der als Punktsummenscore auf Basis von Angaben der Eltern zu ihrer Schulbildung und beruflichen Qualifikation, zu ihrer beruflichen Stellung und zum Netto-Äquivalenzeinkommen berechnet wird. Gegenüber dem Vorgehen in der KiGGS-Basiserhebung wurden einige Änderungen vorgenommen, wie z. B. die Bevorzugung metrischer statt ordinaler Skalierung, die Verwendung internationaler Kriterien bei der Kategorisierung der Variablen und der Zuweisung von Punktwerten sowie die verteilungsbasierte Abgrenzung der Statusgruppen. Diese Änderungen, die mittlerweile auch in den anderen Komponenten des Gesundheitsmonitorings des Robert Koch-Instituts, d. h. der Studie „Gesundheit in Deutschland aktuell“ (GEDA) und der „Studie zur Gesundheit Erwachsener in Deutschland“ (DEGS1), umgesetzt wurden, sollen die Analyse zeitlicher Entwicklungen und Trends ermöglichen, die internationale Vergleichbarkeit der Daten gewährleisten und den Politik- und Praxistransfer der Ergebnisse unterstützen. Um die Verwendung des überarbeiteten Instrumentes zu demonstrieren, werden exemplarisch Ergebnisse der KiGGS Welle 1 zum Zusammenhang zwischen dem soziökonomischen Status und dem allgemeinen Gesundheitszustand von 3- bis 17-jährigen Kindern und Jugendlichen berichtet.
description: This article describes the measurement of socioeconomic status in the first follow-up of the KiGGS study (KiGGS Wave 1) conducted from 2009 to 2012. A multidimensional index score was used. The score is the sum of three metric components: Education and Occupational Qualification, Occupational Status, and Net Income. Compared with the approach in the KiGGS baseline study, some modifications were made in accordance with changes in the other components of the health-monitoring program at the Robert Koch Institute, i.e., the German Health Update (GEDA) and the German Health Interview and Examination Survey for Adults (DEGS1). These changes facilitate the analysis of temporal developments and trends, ensure international comparability of the data, and support the transfer of the results into politics and practice. In order to demonstrate the application of the revised instrument, we report on exemplary results of KiGGS Wave 1 regarding the relationship between socioeconomic status and the general health status of children and adolescents aged 3–17 years.
Background paper to the recommendation for routine rotavirus vaccination of infants in Germany
Creators: name: Koch, Judith
name: Wiese-Posselt, Miriam
name: Remschmidt, Cornelius
name: Wichmann, Ole
name: Bertelsmann, H.
name: Garbe, E.
name: Hengel, Hartmut
name: Meerpohl, Joerg J.
name: Marques, Andreas Mas
name: Oppermann, Hanna
name: Hummers-Pradier, E.
name: Kries, Rüdiger Von
name: Mertens, Thomas
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Germany
subject: Humans
subject: Female
subject: Male
subject: Infant
subject: Infant Newborn
subject: Mass Vaccination/standards
subject: Practice Guidelines as Topic
subject: Rotavirus Infections/prevention & control
subject: Rotavirus Vaccines/standards
subject: Rotavirus Vaccines/therapeutic use
subject: 610 Medizin

description: Two rotavirus (RV) vaccines were introduced to the European market in 2006. To support the decision-making process of the German Standing Committee on Vaccination ("Ständige Impfkommission", STIKO) regarding adoption of routine RV vaccination into the national vaccination schedule in Germany relevant scientific background was reviewed. According to STIKO’s Standard Operating Procedures for the development of evidence-based vaccination recommendations, a set of key questions was addressed and systematic reviews were performed with a focus on the efficacy, effectiveness, impact and safety of RV vaccines. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was applied to assess the quality of available evidence. Data from 5 randomized controlled trials demonstrated a high efficacy of RV vaccines in preventing severe RV-associated gastroenteritis (91%) and hospitalization (92%) in settings comparable to Germany. Post-marketing observational studies confirmed these findings. In several countries, impact studies suggest that age groups not eligible for vaccination might also benefit from herd effects and demonstrated a decrease in the number of nosocomial RV infections after RV vaccine introduction. The vaccines were considered safe, except for a slightly increased risk of intussusception shortly after the first dose, corresponding to 1-2 additional cases per 100,000 infants vaccinated (relative risk =1.21, 95% confidence interval [CI] 0.68-2.14). RV case-fatality is extremely low in Germany. However, RV incidence among children aged
Additional file 1 of Experimental study on photodegradation and leaching of typical pesticides in greenhouse soil from Shouguang, Shandong Province, East China
Creators: name: Hua, Li-Ting
name: Wu, Rui-Lin
name: Li, Cun-Lu
name: Wang, Chao-Nan
name: Li, Yi-Long
name: Xu, Fu-Liu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 1: Table S1. Commonly used pesticides and registered quantities of pesticides in vegetable areas in Shouguang facilities. Table S2. Elution gradient of the mobile phase in liquid chromatography. Table S3. Instrumental analysis parameters of the target pesticides. Table S4. Recovery of typical pesticides in soil. Figure S1. Structural formulas of the 17 target pesticides.
Supplemental Material, sj-pdf-1-gos-10.1177_21514593211026794 - ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): Perceptions in the Assessment and Treatment of Pubic Rami and Sacral Fragility Fractures Amongst Healthcare Professionals in Geriatric Medicine and Surgery—A Qualitative Study
Creators: name: Sahota, Opinder
name: Leighton, Paul
name: Cameron, Maribel
name: Taylor, Rachael
name: Ong, Terence
name: Drummond, Avril
name: Hendrick, Paul
name: Quraishi, Nasir
name: Salem, Khalid
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, sj-pdf-1-gos-10.1177_21514593211026794 for ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): Perceptions in the Assessment and Treatment of Pubic Rami and Sacral Fragility Fractures Amongst Healthcare Professionals in Geriatric Medicine and Surgery—A Qualitative Study by Opinder Sahota, Paul Leighton, Maribel Cameron, Rachael Taylor, Terence Ong, Avril Drummond, Paul Hendrick, Nasir Quraishi, Khalid Salem and On Behalf of the ASSERT Research Team in Geriatric Orthopaedic Surgery & Rehabilitation
Minimising contributions from scattering in infrared spectra by means of an integrating sphere
Creators: name: Dazzi, Alexandre
name: Deniset-Besseau, Ariane
name: Lasch, Peter
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2013
Subjects: subject: Algorithms
subject: Computer Simulation
subject: Light
subject: Microspheres
subject: Polymethyl Methacrylate/chemistry
subject: Scattering Radiation
subject: Spectroscopy Fourier Transform Infrared/methods
subject: 610 Medizin

description: Mid-infrared spectra of biological matter such as tissues or microbial and eukaryotic cells measured in a transmission-type optical setup frequently show strongly distorted line shapes which arise from mixing of absorption and scattering contributions. Scattering-associated distorted line shapes may considerably complicate the analysis and interpretation of the infrared spectra and large efforts have been made to understand the mechanisms of scattering in biological matter and to compensate for spectral alterations caused by scattering. The goals of the present study were two-fold: firstly, to get a deeper understanding of the physics of scattering of biological systems and to explore how physical parameters of the scatterers such as shape, size and refractive index influence the line shape distortions observed. In this context, simulations based on the full Mie scattering formalism for spherical particles were found to be useful in explaining the characteristics of the Mie scatter-associated distortions and yielded a size criterion for the scattering particles similar to the well-known near field criterion. The second objective of the study was to investigate whether alternative optical setups allow minimisation of the effects of scattering. For this purpose, an optical system is proposed which is composed of an integrating sphere unit originally designed for diffuse reflection measurements, an off-axis DLaTGS detector to collect scattered and transmitted light components and a commercial Fourier transform infrared (FTIR) spectrometer. In the context of this study transmission type (tt-) FTIR spectra and spectra acquired by means of the integrating sphere setup (is-FTIR) were acquired from monodisperse poly(methyl) methacrylate (PMMA) microspheres of systematically varying sizes. The tt-FTIR spectral data of different PMMA particles confirmed earlier observations such as the presence of size-dependent oscillating spectral baselines, peak shifts, or derivative-like spectral line shapes. Such effects could be dramatically minimised when is-FTIR spectra were acquired by the integrating sphere unit. Utilisation of an integrating sphere is suggested as a convenient and easy-to use alternative to computer-based methods of scatter correction.
Hepatic adverse events associated with anaplastic lymphoma kinase tyrosine kinase inhibitors: a disproportionality analysis based on FAERS Database and analysis of drug-gene interaction network
Creators: name: Huo, Yan
name: Ma, Minghua
name: Tian, Weiwei
name: Wang, Fang
name: Liao, Xiaolan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are vital for treating ALK-positive cancers but have been associated with liver injury, necessitating further safety investigation. This study examines hepatic adverse event (AE) signals related to ALK TKIs using the U.S. FDA Adverse Event Reporting System (FAERS) and explores potential mechanisms of liver injury. AE reports from FAERS (Q3 2011 to Q1 2024) related to liver injury were analyzed using the reporting odds ratio (ROR) and multi-item gamma Poisson shrinker (MGPS) methods. Pathway enrichment and drug-gene network analyses were performed to investigate underlying mechanisms. This study identified 2,132 AE reports from the FAERS database linking hepatic AEs to ALK TKIs therapy. Significant signals were detected by ROR and MGPS methods, with common AEs including aminotransferase abnormalities, hyperbilirubinemia, and increased blood alkaline phosphatase, mainly occurring within the first 30 days of treatment. Gene analysis revealed key nodes in the protein-protein interaction (PPI) network, such as PIK3CA, SRC, and PTK2. Enriched KEGG pathways included the MAPK, PI3K-Akt, and Ras signaling. This pharmacovigilance study identifies significant AE signals linking ALK TKIs to liver injury, highlighting potential mechanisms and providing insights for clinical management and patient outcomes.
Risk of acute renal failure associated with combined use of SGLT2 inhibitors and potentially nephrotoxic drugs: an epidemiological surveillance study based on the FDA adverse event reporting system (FAERS)
Creators: name: Yu, Ting
name: Xiao, Jian
name: Li, Mengyao
name: Cheng, Shu Qiao
name: Cai, Ruwen
name: Huang, Ling
name: Yu, Huimin
name: Li, Jing Yang
name: Zhang, Ying-Ying
name: Wang, Ying
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Limited knowledge exists regarding nephrotoxic risks associated with the combination of sodium-glucose co-transporter-2 inhibitors (SGLT2i) and potentially nephrotoxic drugs. This study evaluates acute renal failure (ARF) events linked to such combinations using data from the FDA Adverse Event Reporting System (FAERS). Signal mining was performed by estimating reporting odds ratios (ROR), with validation through additive, multiplicative, and proportional reporting ratio (PRR) models. Logistic regression assessed mortality risk factors. Among 4,417,195 reports, 1,636 ARF cases were associated with SGLT2i combinations, primarily involving diuretics, lipid-lowering agents, and anticoagulants. The highest ARF risk was observed with dapagliflozin-cefazolin [ROR adjusted (a) 59.63, 95% CI (9.96, 356.87); ROR adjusted (b) 19.88, 95% CI (1.80, 219.21); additive model (0.53); multiplicative model (8.36); PRR (8.53)]. Consistent associations were found for empagliflozin-allopurinol and canagliflozin-vancomycin. Among single drugs, 12, including canagliflozin, met all four significance criteria for ARF signals. Logistic regression revealed male patients had higher mortality risk (OR = 0.356, p = 0.043). This study confirms prior evidence of ARF associated with the combined use of SGLT2i with diuretics or NSAIDs and identifies new risks with proton pump inhibitors (PPIs), antigout medications, and anticoagulants. Male gender was a significant risk factor.
Influenza vaccination in patients with end-stage renal disease: systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety
Creators: name: Remschmidt, Cornelius
name: Wichmann, Ole
name: Harder, Thomas
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2014
Subjects: subject: Influenza
subject: Vaccine
subject: Dialysis
subject: Effectiveness
subject: End-stage renal disease
subject: GRADE
subject: Systematic review
subject: 610 Medizin

description: Background: Vaccination against influenza is recommended in patients with end-stage renal disease (ESRD). However, so far, no systematic review has summarized the available evidence on the effectiveness and safety of influenza vaccination in this patient group. Methods: We conducted a systematic review and meta-analysis and assessed the quality of evidence using the GRADE methodology. We searched MEDLINE, EMBASE, Cochrane Library databases, ClinicalTrials.gov, and reference lists for studies on efficacy, effectiveness, and/or safety of seasonal influenza vaccination in patients with ESRD receiving dialysis. All reported clinical outcomes were considered, including all-cause mortality, cardiac death, infectious death, all-cause hospitalization, hospitalization due to influenza or pneumonia, hospitalization due to bacteremia, viremia, or septicemia, hospitalization due to respiratory infection, ICU admission, and influenza-like illness. Results: Five observational studies and no randomized-controlled trial were identified. In four studies, risk of bias was high regarding all reported outcomes. Strong residual confounding was likely to be present in one study reporting on three outcomes, as indicated by significant protective effects of vaccination outside influenza seasons. Therefore, the statistically significant protective effects on all-cause mortality (vaccine effectiveness (VE), 32%; 95% CI, 24–39%), cardiac death (VE, 16%; 95% CI, 1–29%), hospitalization due to influenza or pneumonia (VE, 14%; 95% CI, 7–20%), ICU admission (VE, 81%; 95% CI, 63–86%), and influenza-like illness (VE, 12%; 95% CI, 10–14%) have to be taken with caution. According to GRADE, the quality of the body of evidence was considered very low for all outcomes. No study reported on laboratory-confirmed influenza virus infections or on safety endpoints. Conclusions: Evidence on the protective effects of influenza vaccination in patients with ESRD is limited and of very low quality. Since VE estimates in the available literature are prone to unmeasured confounding, studies using randomization or quasi-experimental designs are needed to determine the extent by which vaccination prevents influenza and related clinical outcomes in this at-risk population. However, given the high rates of health-endangering events in these patients, even a low VE can be considered as sufficient to recommend annual influenza vaccination.
Additional file 2 of Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma
Creators: name: Zhao, Haoran
name: Liu, Haishi
name: Kang, Wenli
name: Zhan, Chao
name: Man, Yingchun
name: Qu, Tong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Supplement 2. Other drug susceptibility evaluation.
Hiding in Plain Sight: The Aesthetic of Plainness and the Nineteenth-Century Novel Form
Creators: name: Elliot, Amy L
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: British and Irish literature

description: This dissertation argues that nineteenth-century novelists depended on aesthetically unremarkable—or plain—women characters to establish the realist novel as the genre of the British middle class by mapping class values onto plain women’s bodies. By creating female characters with an unremarkable appearance, novelists train readers in the skills necessary to read the realist novel by focusing on interiority rather than materiality. I theorize plainness as a middle ground between beautiful and ugly that allowed authors to define a morality distinct from the upper and lower classes; plain heroines’ unremarkable exteriors embodied middle-class British values of authenticity, restraint, and morality. More than merely the non-beautiful, plainness delineated a very specific kind of moral and classed female subjectivity. The aesthetic of plainness allowed novelists to engage with cultural discussions of modern female subjectivity, for in creating plain female characters, novelists wrote against idealized depictions of passive women. To accentuate a female character’s inner life, plainness in novels functions primarily through comparison, through networks of represented women. Whereas the literary angel-whore binary has been well-established, I am interested in how the presence of a plain woman—neither angel nor monster—complicates our understanding of heroines in novels. The progressive potential of plain woman speaks to a contemporary movement that rebukes the misogynistic trope of distrusting a woman’s surface and instead portrays plain women with deep feeling and individuated identities.
Safety of proteasome inhibitor drugs for the treatment of multiple myeloma post-marketing: a pharmacovigilance investigation based on the FDA adverse event reporting system
Creators: name: Yu, Dongdong
name: Cheng, Ting
name: Liu, Tong
name: Xu, Wenjun
name: Liu, Dawei
name: Dai, Jinzhi
name: Cai, Shanshan
name: Guan, Yuxiang
name: Ye, Ting
name: Cheng, Xiaoyu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: The use of proteasome inhibitors (PIs), namely Bortezomib and Carfilzomib, revolutionized multiple myeloma (MM) treatment. Understanding their distinct adverse event (AE) profiles aids in tailored treatment plans. We analyzed FDA Adverse Event Reporting System (FAERS) data (Q1 2012-Q4 2023) for Bortezomib and Carfilzomib, utilizing reporting odds ratio (ROR), proportional reporting ratio (PRR), and Bayesian confidence propagation neural network (BCPNN). FAERS yielded 19,720 Bortezomib and 12,252 Carfilzomib AE reports. Males aged 45–65 exhibited higher AE susceptibility. Common AE systems included Infections, Nervous System Disorders, Blood Disorders, General Disorders, Cardiac Disorders, and Renal Disorders. New Bortezomib signals were sepsis and colitis. Carfilzomib exhibited elevated cardiac and renal toxicity but reduced peripheral neuropathy and thrombocytopenia. FAERS analysis revealed new AE signals (sepsis, colitis) for Bortezomib and highlighted Carfilzomib’s heightened cardiac and renal risks compared to Bortezomib. Balancing PIs’ benefits and risks is crucial for clinical decision-making.
Additional file 1 of Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma
Creators: name: Zhao, Haoran
name: Liu, Haishi
name: Kang, Wenli
name: Zhan, Chao
name: Man, Yingchun
name: Qu, Tong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Supplement 1. lncRNA-miRNA-mRNA pathway related parameters.
Safety assessment of selinexor: a real-world pharmacovigilance study
Creators: name: Zhang, Wei
name: Tao, Kai
name: Zeng, Bin
name: Deng, Linghui
name: Lu, Ping
name: Niu, Ting
name: Qiu, Shi
name: Yang, Lu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Selinexor is approved for the treatment of relapsed or refractory multiple myeloma. However, a comprehensive understanding of adverse events associated with selinexor is lacking. Clinical trials of selinexor in patients with multiple myeloma were reviewed. We investigated selinexor-related adverse events through data of the US Food and Drug Administration Adverse Event Reporting System (FAERS). The disproportionality analysis was conducted. Four algorithms were employed to evaluate the signals of adverse events. The adverse effects of selinexor combined with dexamethasone were compared with bortezomib and dexamethasone. Sensitivity analysis was performed to exclude consumer-reported adverse events. The onset of adverse reactions were calculated. A total of 1,698 reports related with selinexor from FAERS were identified. 6 significant system organ class and 42 significant preferred terms (PTs) were found. Unexpected significant adverse events including mania, acute kidney injury, orthostatic hypotension, and embolisms were identified. 14 PTs reported significant signals in treatment of selinexor combined dexamethasone compared with traditional treatment of bortezomib and dexamethasone. 45.2% of adverse events occurred within the first month of starting selinexor. Comprehensive analyses of selinexor related adverse events are helpful for clinical detection of adverse events and timely intervention, advancing selinexor’s therapeutic progress in future treatment.
Additional file 1 of Brain frailty associated with stroke events in anterior circulation large artery occlusion
Creators: name: Tian, Jing
name: Zhang, Kun
name: Cui, Junzhao
name: Qin, Jin
name: Wang, Binbin
name: Zhou, Lixia
name: Li, Tong
name: Bu, Kailin
name: Li, Zhongzhong
name: Liu, Lin
name: Wang, Qisong
name: Yuan, Si
name: Ma, Lina
name: Wang, Ye
name: Wang, Rui
name: Meng, Chaoyue
name: Zhou, Biyi
name: Guo, Li
name: Liu, Xiaoyun
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Supplementary Material 1
How to measure User Experience of art exhibition: methodological proposal
Creators: name: Świetlik, Marta
Publisher: name: Zenodo
Year: 2023
Subjects: subject: UX
subject: User experience
subject: art exhibition
subject: audience research
subject: curatorial research
subject: Modern and contemporary art
subject: reception research
subject: Digital humanities
subject: Art history

description: "How to Measure User Experience of Art Exhibition: Methodological Proposal"

This poster introduces an innovative approach to evaluating the user experience (UX) of contemporary art exhibitions. Developed as part of Marta M. Świetlik’s doctoral project in digital humanities, the research explores how UX methodologies can assess exhibitions as platforms for social exchange. Świetlik's dissertation, titled "User Experience Design in the Art Field: Contemporary Art Exhibitions as Platforms of Social Exchange," was successfully defended in December 2023 at Jagiellonian University.

The study was conducted between 2019 and 2023 as part of the "Digital Humanities: Doctoral Studies" program, a collaboration between the Institute of Literary Research of the Polish Academy of Sciences and the Polish-Japanese Academy of Information Technology. The program was co-financed by the European Union under the Operational Programme Knowledge Education Development.

The research employed mixed methods, integrating social sciences, marketing research, and UX tools. Case studies included both physical and virtual exhibitions, revealing insights about user behaviour, navigation challenges, and the alignment of curatorial goals with visitor experiences. Key findings emphasize the need for tailored UX tools in exhibition design to address accessibility, emotional engagement, and the broader "usability of art."

The poster was first presented during the 10th-anniversary event of the Digital Humanities Center at the Institute of Literary Research of the Polish Academy of Sciences (IBL PAN) in late November 2023.
Drug-induced hepatitis B virus reactivation: insights from FAERS database analysis
Creators: name: Zhang, Genshan
name: Yan, Hanpeng
name: Zhang, Haokun
name: Zhu, Lin
name: Fu, Jie
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Reactivation of the hepatitis B virus (HBV) induced by drugs is a commonly overlooked but clinically significant complication, posing risks of treatment interruptions, hepatitis exacerbation, liver failure, and even mortality. Disproportionality analyses were conducted on the Food and Drug Administration Adverse Event Reporting System (FAERS) database data spanning from January 2017 to December 2023 to detect drugs posing a risk of HBV reactivation (HBV-R). HBV-R cases were identified using the Medical Dictionary for Regulatory Activities (MedDRA), and drug generic names were ascertained from the DrugBank database. A total of 2596 adverse event reports (AERs) were found to be related to drug-induced HBV-R.According to the disproportionality analysis, the top five drugs with the highest ROR and PRR were daklinza, vocabria, doxorubicin, sovaldi, and ribavirin. The top 40 drugs causing drug-induced HBV-R can be roughly divided into three categories: anti-tumor drugs, immunosuppressive drugs, and antiviral drugs. Among them, 23 drugs do not explicitly mention the risk of HBV-R in their drug instructions. It was observed that some pharmaceuticals do not adequately address the risk of HBV-R in their drug documentation. These findings could assist healthcare providers in promptly recognizing drug-induced HBV-R.
sj-pdf-1-tag-10.1177_17562848211024769 – Supplemental material for The real-world outcomes of vedolizumab in patients with ulcerative colitis in Korea: a multicenter retrospective study
Creators: name: Ye, Byong Duk
name: Cheon, Jae Hee
name: Song, Ki Hwan
name: Kim, Joo Sung
name: Kim, Young-Ho
name: Yoon, Hyuk
name: Lee, Kang-Moon
name: Kang, Sang-Bum
name: Jang, Byung Ik
name: Park, Jae Jun
name: Kim, Tae Oh
name: Lee, Dae-Wook
name: Foo, Chee Yoong
name: Shin, Jeong Eun
name: Park, Dong Il
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-tag-10.1177_17562848211024769 for The real-world outcomes of vedolizumab in patients with ulcerative colitis in Korea: a multicenter retrospective study by Byong Duk Ye, Jae Hee Cheon, Ki Hwan Song, Joo Sung Kim, Young-Ho Kim, Hyuk Yoon, Kang-Moon Lee, Sang-Bum Kang, Byung Ik Jang, Jae Jun Park, Tae Oh Kim, Dae-Wook Lee, Chee Yoong Foo, Jeong Eun Shin and Dong Il Park in Therapeutic Advances in Gastroenterology
Exploring the Employability Skills and Academic Success of the National FFA Membership
Creators: name: Copeland, Britt
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: Employability skills such as communication, leadership, and critical thinking are in high demand from employers and colleges alike (Crawford, Lang, Fink, Dalton, & Fielitz, 2011; Easterly, Warner, Lamm, & Telg, 2017). In a competitive employment environment, applicants must strive to achieve academic success and proficiency in their field of interest. They also need to possess a command over employability skills that are broadly applicable to all aspects of business (Boahin & Hofman, 2013). A descriptive census of 2018-2019 high school senior members of the National FFA Organization was conducted to provide an updated and focused look into the National FFA student membership. Its goal was to assess the level of employability skills and academic success retained through high school and participation, within the organization, that takes into account the evolution of employability skills desired by the 21st Century job market. Exploring, defining, and understanding the current National FFA student membership’s achievements and interests in career pathways is important in ensuring the optimal educational experience for today’s youth. The study took place over nine weeks in the fall of 2018 with 2,087 respondents completing the online survey. Informed consent and parental consent were collected completely online. Respondents self-reported their Youth Leadership Life Skills, Critical Thinking Dispositions, Communication Competence, High School GPAs, Standardized Test Scores, FFA Involvement/Enrollment, and their interests in AFNR Career Pathways. Results of the study indicated that respondents self-perceived high employability skill levels and above average academic success compared to National Average Standardized Test Scores. These results could be translated into College and Career Readiness of the study respondents. Significant relationships were found between employability skill levels, academic success, and respondent’s level of FFA Involvement. Recommendations for future research include replicating this study within the next 10 years and using a standardized scale to collect self-reported high school GPAs. It would also be beneficial to review USDE high school transcript studies to uncover why “class scheduling problems” were reported as the most common reason for gaps in FFA enrollment.
Outbreak of Salmonella Montevideo associated with a dietary food supplement flagged in the Rapid Alert System for Food and Feed (RASFF) in Germany, 2010
Creators: name: Stöcker, Petra
name: Rosner, Bettina
name: Werber, Dirk
name: Kirchner, Markus
name: Reinecke, Annette
name: Wichmann-Schauer, Heidi
name: Prager, Rita
name: Rabsch, Wolfgang
name: Frank, Christina
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2011
Subjects: subject: Adolescent
subject: Humans
subject: Female
subject: Disease Outbreaks
subject: Germany/epidemiology
subject: Salmonella Food Poisoning/epidemiology
subject: Male
subject: Middle Aged
subject: Child
subject: Adult
subject: Case-Control Studies
subject: Aged
subject: Infant
subject: Young Adult
subject: Child Preschool
subject: Aged 80 and over
subject: Dietary Supplements/microbiology*
subject: Information Systems
subject: FOS: Computer and information sciences
subject: 610 Medizin

description: In March 2010 the Rapid Alert System for Food and Feed (RASFF) was used to inform about Salmonella Montevideo in a herbal food supplement, formulated in capsules, distributed under a Dutch label in Germany. Simultaneous to the first RASFF notice, in the last two weeks of March 2010 an unusual number of 15 infections with S. Montevideo was notified within the electronic reporting system for infectious diseases at the Robert Koch Institute. Adult women (median age: 43, range: 1–90 years) were mainly affected. An outbreak was suspected and the food supplement hypothesised to be its vehicle. Cases were notified from six federal states throughout Germany, which required efficient coordination of information and activities. A case–control study (n=55) among adult women showed an association between consumption of the specific food supplement and the disease (odds ratio (OR): 27.5, 95% confidence interval (CI): 3.1–infinity, p-value=0.002). Restricting the case–control study to the period when the outbreak peaked (between 29 March and 11 April 2010) resulted in an OR of 43.5 (95% CI: 4.8–infinity, p-value=0.001). Trace-back of the supplement’s main ingredient, hemp seed flour, and subsequent microbiological testing by pulsed-field gel electrophoresis supported its likely role in transmission. This outbreak investigation illustrates that information from RASFF may aid in hypothesis generation in outbreak investigations, though likely late in the outbreak.
Attention to the interactions between vincristine and triazole antifungals: perspectives from real-world retrospective analysis and pharmacovigilance assessment
Creators: name: Huang, Dan
name: Zhang, Ye
name: Liu, Lin
name: Yang, Minghua
name: Zeng, Ting
name: Wang, Shengfeng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: Virology

description: In patients with hematologic malignancies, the combination of triazole antifungals and vincristine can lead to severe neurological toxicity. We attempted to assess the adverse events (AEs) associated with these interactions, particularly ileus. We retrieved AEs data from FAERS database (2004–2023) focusing on the combination of four triazoles (fluconazole, itraconazole, voriconazole, posaconazole) with vincristine. Case reports of AEs were collected for retrospective analysis up to 31 December 2023. The FAERS database indicated that neurological and gastrointestinal systems were most commonly involved systems when combined use triazole antifungals and vincristine, with ileus being the most frequently reported AE. The highest signal strengths for ileus were with itraconazole. AEs associated with concomitant use of triazole antifungal drugs and vincristine were identified through retrospective analysis of 42 clinical case reports, of which itraconazole, posaconazole, and voriconazole were involved in 66.7%, 28.6%, and 4.8% of cases, respectively. Patients who received the two-drug combination experienced AEs within one month in 88.1% of cases. Almost all patients improved within one month after discontinuing or switching antifungal drugs. Ileus is the most common AE associated with the combination of triazole antifungals and vincristine, with itraconazole showing the highest risk.
2021 MLA Poster Session: Presentation Transcript
Creators: name: Agostini, Caterina
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Digital humanities
subject: Europe
subject: Sixteenth century
subject: Seventeenth century
subject: Italy
subject: Area studies

description: This is the transcript for my video presentation, in which I showcase my Digital Humanities project on Galileo's letters.
2021 MLA Poster Session: Presentation Transcript
Creators: name: Agostini, Caterina
Publisher: name: unknown
Year: 2020
Subjects: subject: Digital humanities
subject: Seventeenth century
subject: Europe
subject: Italy
subject: Area studies
subject: Sixteenth century

description: This is the transcript for my video presentation, in which I showcase my Digital Humanities project on Galileo's letters.
Additional file 1 of Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo
Creators: name: Kayiba, Nadine Kalenda
name: Nitahara, Yuko
name: Tshibangu-Kabamba, Evariste
name: Mbuyi, Denis Kalambayi
name: Kabongo-Tshibaka, Augustin
name: Kalala, Nestor Tshituka
name: Tshiebue, Barthélemy Mukenga
name: Candray-Medina, Katherine-Sofia
name: Kaku, Natsuko
name: Nakagama, Yu
name: Speybroeck, Niko
name: Mumba, Dieudonné Ngoyi
name: Disashi, Ghislain Tumba
name: Kaneko, Akira
name: Kido, Yasutoshi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Figure S1. Surveys assessing P. falciparum infections across Africa. These maps display prevalence estimates of P. falciparum infections through the entire Africa (A) and through the DRC (B) based on the pulled data sources provided by the Malaria Atlas Project (MAP) ( https://malariaatlas.org/pf-pv-cubes-2019/ ). Color palettes reflect the relative prevalence predicted at each site. The Lukelenge health zone where the current survey was conducted is indicated. Table S1. Baseline socio-demographic characteristics of the study population. Table S2. Self-reported history of putative clinical malaria episodes and use of preventive measures in the study population. Table S3. Qualitative agreement between assays for the detection of P. falciparum malaria in the study population. Table S4. Qualitative agreement between assays for the detection of non-falciparum malaria in the study population
Inanspruchnahme des Gesundheitswesens - Erste Ergebnisse des telefonischen Gesundheitssurveys 2003
Creators: name: Bergmann, Eckardt
name: Kalcklösch, Margrit
name: Tiemann, F.
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2005
Subjects: subject: Inanspruchnahme
subject: Hausarzt
subject: Vorsorge
subject: Krankenhausaufenthalte
subject: Rehabilitation
subject: Prevention
subject: Health care utilisation
subject: Family doctor
subject: Inpatient health care
subject: 610 Medizin

description: Über 90% der Erwachsenen haben schon heute einen Hausarzt. Die Anzahl der Arztkontakte beim Hausarzt wächst mit der Anzahl der chronischen Krankheiten eines Befragten und den Störungen in seiner subjektiven Gesundheit. Ältere Mitbürger, Personen mit niedrigerem Sozialstatus und mit einem höheren BMI suchen einen Hausarzt häufiger auf. Personen mit höherem Alkoholkonsum (Selbsteinschätzung) gehen seltener zu ihrem Arzt. Privatversicherte nehmen auch den Hausarzt seltener in Anspruch. Fast 2/3 der erwachsenen Bevölkerung in Deutschland waren in den letzten 3 Monaten bei einem Arzt in ambulanter Behandlung. 44% der über 60-Jährigen haben einen aktuellen Grippeimpfschutz. Die Impfbereitschaft bezüglich der Grippeschutzimpfung ist im Osten erheblich höher als im Westen. Mehr als die Hälfte der Befragten über 35 Jahre hat schon einmal an einem Gesundheits-Checkup teilgenommen. Bei Männern wird der Checkup etwas häufiger durchgeführt. Die mindestens einmalige Teilnahme an der Krebsfrüherkennung gaben über 80% der Frauen an. Immerhin 60% der Frauen haben im letzten Jahr eine Krebsfrüherkennung durchführen lassen. Männer nehmen das Angebot zur Krebsfrüherkennung seltener an. Im Durchschnitt liegt ein Krankenhauspatient 2 Wochen im Jahr im Krankenhaus. An einer medizinischen Rehabilitationsmaßnahme haben knapp 30% der Befragten teilgenommen.
description: More than 90% of adults have a family doctor. The more chronic diseases and the more subjective health problems the interviewees had, the more often they had been to see their family doctor. Senior citizens and people with lower social status or a higher BMI go to see their family doctors more frequently. People who say they consume a lot of alcohol consult a doctor less often than others. Privately insured people also go to see their family doctors less frequently. Almost two-thirds of the adult population in Germany have seen a doctor in the last 3 months, and 44% of people over 60 had an influenza vaccination this year. People are much more willing to have an influenza injection in eastern Germany than in the west. More than half of the people questioned over the age of 35 has had a general health check-up at least once in their lives. Men have health check-ups slightly more often than women do. Of the women, 80% have participated at least once in a cancer screening programme, and as many as 60% of women had a cancer scan during the last year. Men take up cancer screening offers less often than women do. Inpatients stay for an average of 2 weeks in hospital per year. Just under 30% of those questioned have had medical rehabilitation treatment.