cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamics of caspase activation upon UV induced genotoxic injury
Creators: name: Mayer, Felicitas
name: Kemnitz, Ivonne
name: Fitze, Guido
name: Haase, Michael G
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Caspases are common mediators of cell death. Evasion of cell death including apoptosis are considered to be hallmarks of cancer. A deeper understanding of the apoptotic cascade may aid improving cancer therapies. Our aim was to characterize the progression of cell death following UV-induced genotoxic injury in a defined cell culture model. Hela cells were UV-irradiated with doses ranging from 0.1 to 60 mJ/cm2. Cells were counted and colony forming assays were performed with caspase inhibitors. In our model of HeLa cells, cells remain >90% viable until 6 hrs after UV radiation (UVR), but more than half of the cells are dead after 12 − 72 hrs after UVR. Within a dose range between 0.1 and 50 mJ/cm2, viability ranges roughly between 20 and 30%. The difference between the lowest dose applied (0.1 mJ/cm2) and the other doses applied is significant, with the exception of the next higher dose of 1 mJ/cm2. The activation of caspases precedes the cell death induction by several hrs. Caspase-9 starts to be activated at 1 hr after UVR followed by caspases 3, 6 and 7 which are fully active at 2 hrs after UVR while caspase-8 is fully active only 3 hrs after UVR. Most caspases are only weakly or not active at 0.1 mJ/cm2 after 3 hrs, but fully active at the same time point with increased radiation doses. PARP-1, a caspase substrate, is cleaved immediately after activation of the caspases. Colony formation activity of the tumor cells decreases exponentially after UVR dropping down to < 0.01% plating efficiency at a dose of 60 mJ/cm2. Interestingly, this drop in plating efficiency cannot be rescued by any of the two caspase inhibitors tested. UV-induced cell death in this model involves the activation of apoptosis-related caspases, but this activation seems to be dispensable for the execution of cell death. Further experiments should clarify which mechanisms of cell death are really necessary for the execution of this type of cell death.
Entanglement in the Bogoliubov vacuum
Creators: name: Poulsen, U. V.
name: Meyer, T.
name: Lewenstein, M.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We analyze the entanglement properties of the Bogoliubov vacuum, which is obtained as a second order approximation to the ground state of an interacting Bose--Einstein condensate. We work on one and two dimensional lattices and study the entanglement between two groups of lattice sites as a function of the geometry of the configuration and the strength of the interactions. As our measure of entanglement we use the logarithmic negativity, supplemented by an algorithmic check for bound entanglement where appropriate. The short-range entanglement is found to grow approximately linearly with the group sizes and to be favored by strong interactions. Conversely, long range entanglement is favored by relatively weak interactions. Working with periodic boundary conditions we find some surprising finite size effects for the very long range entanglement. No examples of bound entanglement is found.
description: 11 pages, 7 figures
The origin and structure of clumps along molecular outflows: the test case of CB3
Creators: name: Viti, Serena
name: Codella, Claudio
name: Benedettini, Milena
name: Bachiller, Rafael
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the origin of the small, chemically rich molecular clumps observed along the main axis of chemically rich outflows such as CB3 and L1157. We develop a chemical model where we explore the chemical evolution of these clumps, assuming they are partially pre-existing to the outflow, or alternatively newly formed by the impact of the outflow on the surrounding medium. The effects of the impact of the outflow are reproduced by density and temperature changes in the clump. We find that the observed abundances of CH3OH, SO and SO2 are best reproduced by assuming a scenario where the dense molecular gas observed is probably pre-existing in the interstellar medium before the formation of their exciting (proto)stars and that the clumpiness and the rich chemistry of the clumps are a consequence of a pre-existing density enhancement and of its interaction with the outflow.
description: 11 pages, 5 figures, accepted by MNRAS; corrected label in figure 5
Improved local spectral gap thresholds for lattices of finite dimension
Creators: name: Anshu, Anurag
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Knabe's theorem lower bounds the spectral gap of a one dimensional frustration-free local hamiltonian in terms of the local spectral gaps of finite regions. It also provides a local spectral gap threshold for hamiltonians that are gapless in the thermodynamic limit, showing that the local spectral gap much scale inverse linearly with the length of the region for such systems. Recent works have further improved upon this threshold, tightening it in the one dimensional case and extending it to higher dimensions. Here, we show a local spectral gap threshold for frustration-free hamiltonians on a finite dimensional lattice, that is optimal up to a constant factor that depends on the dimension of the lattice. Our proof is based on the detectability lemma framework and uses the notion of coarse-grained hamiltonian (introduced in [Phys. Rev. B 93, 205142]) as a link connecting the (global) spectral gap and the local spectral gap.
description: version 1, 18 pages, 3 figures
MOESM2 of The cost-effectiveness of pegaspargase versus native asparaginase for first-line treatment of acute lymphoblastic leukaemia: a UK-based cost-utility analysis
Creators: name: Xingdi Hu
name: Wildman, Kingsley
name: Subham Basu
name: Lin, Peggy
name: Rowntree, Clare
name: Vaskar Saha
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 2: Table S1. Cost Analysis by category. Table S2. Scenario Analyses.
Mapping Marginality Hotspots – Geographical Targeting for Poverty Reduction
Creators: name: Graw, Valerie
name: Husmann, Christine Ladenburger
name: Graw, Valerie
name: Husmann, Christine Ladenburger
Publisher: name: Unknown
Year: 2012
Subjects: subject: Food Security and Poverty
subject: International Development
subject: Research Methods/ Statistical Methods
subject: GIS
subject: Marginality
subject: Poverty Mapping
subject: Hotspot Mapping
subject: Spheres of Life

description: This mapping approach aims to make the marginalized and poor visible by identifying areas with difficult biophysical and socio-economic conditions. Mapping using different data sources and data types gives deeper insight into possible causal interlinkages and offers the opportunity for comprehensive analysis. The maps highlight areas where different dimensions of marginality overlap – the marginality hotspots – based on proxies for marginality dimensions representing different spheres of life. Furthermore, overlaying the marginality hotspots with the number of poor shows where most of the poor could be reached to help them to escape the spiral of poverty. Marginality hotspots can be found in particular in India and Nepal as well as in several countries in Central and Eastern Africa, such as Eritrea, Mozambique, Central African Republic, the Democratic Republic of Congo, Northern Sudan and large parts of Niger. Maps showing the overlap between marginality and poverty highlight that the largest number of marginalized poor are located in India and Bangladesh, as well as in Ethiopia, Southeastern Africa and some parts of Western Africa.
Search for bosonic stop decays in R-parity violating supersymmetry in e^+ p collisions at HERA
Creators: name: H1 Collaboration
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for scalar top quarks in R-parity violating supersymmetry is performed in e^+ p collisions at HERA using the H1 detector. The data, taken at sqrt{s}=319 GeV and 301 GeV, correspond to an integrated luminosity of 106 pb^-1. The resonant production of scalar top quarks \tilde{t} in positron quark fusion via an R-parity violating Yukawa coupling lambda' is considered with the subsequent bosonic stop decay \tilde{t} -> \tilde{b} W. The R-parity violating decay of the sbottom quark tilde{b} -> d \bar{nu_e} and leptonic and hadronic W decays are considered. No evidence for stop production is found in the search for bosonic stop decays nor in a search for the direct R-parity violating decay \tilde{t} -> eq. Mass dependent limits on lambda' are obtained in the framework of the Minimal Supersymmetric Standard Model. Stop quarks with masses up to 275 GeV can be excluded at the 95% confidence level for a Yukawa coupling of electromagnetic strength.
description: 20 pages, 5 figures and 2 tables
Estimating Demand for Differentiated Products: The Case of Beer in the U.S.
Creators: name: Rojas, Christian
name: Peterson, Everett
name: Rojas, Christian
name: Peterson, Everett
Publisher: name: Unknown
Year: 2005
Subjects: subject: Demand and Price Analysis
subject: Marketing
subject: FOS: Economics and business
subject: Demand
subject: differentiated products
subject: distance metric
subject: Almost Ideal Demand System
subject: advertising
subject: beer

description: This paper employs a nation-wide sample of supermarket scanner data to estimate a large brandlevel demand system for beer in the U.S. Unlike previous studies, this work estimates the ownand cross-advertising elasticities in addition to price elasticities. The dimensionality problem is solved with the Distance Metric method of Pinkse, Slade and Brett and the demand model follows the flexible Almost Ideal demand system. While price elasticities are consistent with previous results, positive and negative cross-advertising elasticities imply the presence of both cooperative and predatory effects of advertising expenditures across brands; however, the former effect appears to dominate suggesting that advertising increases the overall demand for beer.
Additional file 2 of Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
Creators: name: Savi, Monia
name: Bocchi, Leonardo
name: Cacciani, Francesca
name: Rocchina Vilella
name: Buschini, Annamaria
name: Perotti, Alessio
name: Galati, Serena
name: Montalbano, Serena
name: Pinelli, Silvana
name: Frati, Caterina
name: Corradini, Emilia
name: Quaini, Federico
name: Ruotolo, Roberta
name: Stilli, Donatella
name: Zaniboni, Massimiliano
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2: Supplementary Fig. S2. TEM analysis of left ventricular tissue from control rat. Panel a: low magnification image of a cardiomyocyte (N, nucleus) filled of mitochondria (Mit) and myofibrils (MF). In the interstitial space an endothelial cell (Ec) is lining a capillary lumen (RB, red blood cells). Panel b: image showing mitochondria (Mit) and myofribrils (MF) in a CTRL rat myocardium (N, myocyte nucleus) at higher magnification. Scale Bars: a: 5 μm; b: 2 μm.
Neocollyris (Isocollyris) resplendens
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Neocollyris
Neocollyris resplendens

description: 21. Neocollyris (Isocollyris) resplendens (Horn, 1902) (Fig. 21, 218)
 Collyris resplendens: Horn 1902: 66, 67; 1913: 362; 1924: 5.
 Neocollyris (Isocollyris) resplendens: Naviaux 1995a: 71, 72.
 Published data. NORTHEAST: Lang Son (Mont Mau Son) (Horn 1902: 66; 1913: 362; 1924: 5; Naviaux 1995a: 71).
 New records. NORTH CENTRAL COAST: Thua Thien-Hue, Bach Ma National Park, 1200m, N16 o 11’ 38” E107 o 51’ 23”, E. Orbach, 30.v.2017, 1 female (EOIC).
 Distribution. Vietnam (Lang Son, Thua Thien-Hue).
 Remarks. New provincial record for Thua Thien-Hue.
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 12, DOI: 10.5281/zenodo.5169363
Fundamental Crystal Field Excitations in Magnetic Semiconductor SnO$_2$:Mn,Fe,Co,Ni
Creators: name: Leedahl, B.
name: McCloskey, D. J.
name: Boukhvalov, D. W.
name: Zhidkov, I. S.
name: Kukharenko, A. I.
name: Kurmaev, E. Z.
name: Cholakh, S. O.
name: Gavrilov, N. V.
name: Brinzari, V. I.
name: Moewes, A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Directly measuring elementary electronic excitations in dopant $3d$ metals is essential to understanding how they function as part of their host material. Through calculated crystal field splittings of the $3d$ electron band it is shown how transition metals Mn, Fe, Co, and Ni are incorporated into SnO$_2$. The crystal field splittings are compared to resonant inelastic x-ray scattering (RIXS) experiments, which measure precisely these elementary $dd$ excitations. The origin of spectral features can be determined and identified via this comparison, leading to an increased understanding of how such dopant metals situate themselves in, and modify the host's electronic and magnetic properties; and also how each element differs when incorporated into other semiconducting materials. We found that oxygen vacancy formation must not occur at nearest neighbour sites to metal atoms, but instead must reside at least two coordination spheres beyond. The coordination of the dopants within the host can then be explicitly related to the $d$-electron configurations and energies. This approach facilitates an understanding of the essential link between local crystal coordination and electronic/magnetic properties.
Dynamics of Caspase Activation upon UV induced Genotoxic Injury
Creators: name: Mayer, Felicitas
name: Kemnitz, Ivonne
name: Fitze, Guido
name: Haase, Michael G
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Caspases are common mediators of cell death. Evasion of cell death including apoptosis are considered to be hallmarks of cancer. A deeper understanding of the apoptotic cascade may aid improving cancer therapies. Our aim was to characterize the progression of cell death following UV-induced genotoxic injury in a defined cell culture model. Hela cells were UV-irradiated with doses ranging from 0.1 – 60 mJ/cm2. Cells were counted and colony forming assays were performed with caspase inhibitors. In our model of HeLa cells, cells remain >90% viable until 6 hrs after UV radiation (UVR), but more than half of the cells are dead after 12 -72 hrs after UVR. Within a dose range between 0.1 and 50 mJ/cm2, viability ranges roughly between 20 and 30%. The difference between the lowest dose applied (0.1 mJ/cm2) and the other doses applied is significant, with the exception of the next higher dose of 1 mJ/cm2. The activation of caspases precedes the cell death induction by several hrs. Caspase-9 starts to be activated at 1 hr after UVR followed by caspases 3, 6 and 7 which are fully active at 2 hrs after UVR while caspase-8 is fully active only 3 hrs after UVR. Most caspases are only weakly or not active at 0.1 mJ/cm2 after 3 hrs, but fully active at the same time point with increased radiation doses. PARP-1, a caspase substrate, is cleaved immediately after activation of the caspases. Colony formation activity of the tumor cells decreases exponentially after UVR dropping down to less than 0.01% plating efficiency at a dose of 60 mJ/cm2. Interestingly, this drop in plating efficiency cannot be rescued by any of the two caspase inhibitors tested. UV-induced cell death in this model involves the activation of apoptosis-related caspases, but this activation seems to be dispensable for the execution of cell death. Further experiments should clarify which mechanisms of cell death are really necessary for the execution of this type of cell death.
Anomaly interplay in $U(2)$ gauge theories
Creators: name: Davighi, Joe
name: Lohitsiri, Nakarin
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss anomaly cancellation in $U(2)$ gauge theories in four dimensions. For a $U(2)$ gauge theory defined with a spin structure, the vanishing of the bordism group $Ω_5^{\text{Spin}}(BU(2))$ implies that there can be no global anomalies, in contrast to the related case of an $SU(2)$ gauge theory. We show explicitly that the familiar $SU(2)$ global anomaly is replaced by a local anomaly when $SU(2)$ is embedded in $U(2)$. There must be an even number of fermions with isospin $2r+1/2$, for $r\in \mathbb{Z}_{\geq 0}$, for this local anomaly to cancel. The case of a $U(2)$ theory defined without a choice of spin structure but rather using a spin-$U(2)$ structure, which is possible when all fermions (bosons) have half-integer (integer) isospin and odd (even) $U(1)$ charge, is more subtle. We find that the recently-discovered `new $SU(2)$ global anomaly' is also equivalent, though only at the level of the partition function, to a perturbative anomaly in the $U(2)$ theory, which is this time a combination of a mixed gauge anomaly with a gauge-gravity anomaly. This perturbative anomaly vanishes if there is an even number of fermions with isospin $4r+3/2$, for $r\in \mathbb{Z}_{\geq 0}$, recovering the condition for cancelling the new $SU(2)$ anomaly. Alternatively, this perturbative anomaly can be cancelled by a Wess--Zumino term, leaving a low-energy theory with a global anomaly, which can itself be cancelled by coupling to topological degrees of freedom.
description: 23 pages, 2 figures. Description of the mapping tori for U(2) vs SU(2) has been made clearer
Effective Potential in Glass Forming Liquids
Creators: name: de Candia, Antonio
Publisher: name: arXiv
Year: 2004
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The effective potential formalism is applied to glass forming liquids, choosing a coupling potential such that the "order parameter", conjugated to the coupling strength, is the mean square displacement of the particles from their position in the quenched reference configuration. The potential is linear in some interval of its argument, signaling the coexistence of two phases in the system, one with low and one with high mean square displacement. Within this formalism, one can also compute the free energy of metastable states and their complexity.
description: 4 pages, 3 eps figures
The formation and decay of sunspot penumbra in Active Region NOAA 12673
Creators: name: Li, Qiaoling
name: Yan, Xiaoli
name: Wang, Jincheng
name: Kong, Defang
name: Xue, Zhike
name: Yang, Liheng
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: To better understand the formation and decay of sunspot penumbra, we studied the evolution of sunspots in the three regions of the active-region NOAA 12673 in detail. The evolution of sunspots in the three regions were all involved in the interaction of two magnetic field systems: the pre-existing magnetic field system and the later emerging magnetic field system. Through analyzing the photospheric magnetic field properties, it is found that the formation of the penumbra originated from the newly emerging magnetic bipole that were trapped in the photosphere. The change of magnetic fields in penumbra from horizontal to vertical can cause the disappearance of penumbra. The transformation of the magnetic field between the umbra and the penumbra is found and the outward moat flow around sunspot gradually decreased and vanished during the decay of sunspot. In addition, we found that the mean longitudinal magnetic strength in penumbra decreased and the mean transverse magnetic strength in penumbra increased with the increasing penumbral area during the formation of sunspots. However, during the decay of sunspots, the mean longitudinal magnetic strength in penumbra increased and the mean transverse magnetic strength in penumbra decreased with the decreasing penumbral area. Comparatively, the dependence of the area and the mean transverse/longitudinal magnetic field strength in umbra is not remarkable. These results reveal that the formation and decay process of umbra are different with penumbra.
description: 27 pages, 20 figures, accepted for publication in ApJ
The Theory of Price Collars: The Linking of Prices in a Market Channel to Redress the Exercise of Market Power
Creators: name: Tian, Li
name: Cotterill, Ronald
name: Tian, Li
name: Cotterill, Ronald
Publisher: name: Unknown
Year: 2004
Subjects: Demand and Price Analysis

description: The marketing channels for many goods involve the production of a raw commodity that is processed and then distributed to retailers for sale to consumers. Either the processing industry or the retailing industry or both may exercise substantial market powe r ultimately against raw commodity suppliers or consumer s, the disorganized (competitive) economic groups at the ends of the market channel. This paper develops a theory of price collars to regulate pricing in such a channel. Price collars link raw product, wholesale and retail prices but do not explicitly set such prices. For example, a wholesale price collar could limit the wholesale price to 140% of the raw commodity price, and a retail price collar could limit retail price to 130% of the wholesale price.
MOESM1 of The cost-effectiveness of pegaspargase versus native asparaginase for first-line treatment of acute lymphoblastic leukaemia: a UK-based cost-utility analysis
Creators: name: Xingdi Hu
name: Wildman, Kingsley
name: Subham Basu
name: Lin, Peggy
name: Rowntree, Clare
name: Vaskar Saha
Publisher: name: figshare
Year: 2019
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 1. CHEERS checklist.
Study of the process $e^+e^- \to π^+π^-π^0$ in the energy region $\sqrt[]{s}$ below 0.98 GeV
Creators: name: Achasov, M. N.
name: Beloborodov, K. I.
name: Berdyugin, A. V.
name: Bogdanchikov, A. G.
name: Bozhenok, A. V.
name: Bukin, A. D.
name: Bukin, D. A.
name: Dimova, T. V.
name: Druzhinin, V. P.
name: Golubev, V. B.
name: Koop, I. A.
name: Korol, A. A.
name: Koshuba, S. V.
name: Lysenko, A. P.
name: Pakhtusova, E. V.
name: Serednyakov, S. I.
name: Shary, V. V.
name: Shatunov, Yu. M.
name: Silagadze, Z. K.
name: Skrinsky, A. N.
name: Valishev, A. A.
name: Vasiljev, A. V.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The cross section of the process $e^+e^-\to π^+π^-π^0$ was measured in the Spherical Neutral Detector (SND) experiment at the VEPP-2M collider in the energy region $\sqrt[]{s}$ below 980 MeV. This measurement was based on about $1.2 \times 10^6$ selected events. The obtained cross section was analyzed together with the SND and DM2 data in the energy region $\sqrt[]{s}$ up to 2 GeV. The $ω$-meson parameters: $m_ω=782.79\pm 0.08\pm 0.09$ MeV, $Γ_ω=8.68\pm 0.04\pm 0.15$ MeV and $σ(ω\to 3π)=1615\pm 9\pm 57$ nb were obtained. It was found that the experimental data cannot be described by a sum of only $ω$, $ϕ$, $ω^\prime$ and $ω^{\prime\prime}$ resonances contributions. This can be interpreted as a manifestation of $ρ\to 3π$ decay, suppressed by $G$-parity, with relative probability $B(ρ\to 3π) = (1.01\pm^{0.54}_{0.36}\pm 0.034) \times 10^{-4}$.
description: 41 pages REVTEX and 34 figures
Asymmetric Response of Retail Milk Prices in the Northeast Revisited
Creators: name: Lass, Daniel A.
name: Lass, Daniel A.
Publisher: name: Unknown
Year: 2005
Subjects: subject: Demand and Price Analysis
subject: asymmetry
subject: fluid milk
subject: retail prices
subject: farm-to-retail price margins

description: Retail milk price responses to farm price changes were analyzed for Boston, Massachusetts, and Hartford, Connecticut. Prior research concluded asymmetries did not exist in the response of retail fluid milk prices to changes in farm prices. This study finds transmission rates were greater for the Compact period (100 – 120 percent) than the Pre-Compact period (66 – 88 percent). Short-run asymmetries were apparent. Retail prices responded rapidly to farm price increases, but slowly to farm price decreases. This study also finds evidence of long-run asymmetry. When equivalent farm price increases and decreases occur, retail prices do not return to the same levels that were observed before the price changes. Such long-run asymmetry was not observed in prior empirical studies of retail prices in the Northeast.
Neocollyris (Isocollyris) purpurascens : Naviaux 1992
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Neocollyris
Neocollyris purpurascens

description: 23.  Neocollyris (Isocollyris) purpurascens  Naviaux, 1992 (Fig. 23, 220)
 Neocollyris purpurascens: Naviaux 1992b: 452.
 Published data. RED RIVER DELTA: Vinh Phuc (Tam Dao) (Naviaux 1992b: 452).
 New records. NORTHEAST: Tuyen Quang, 160 km NNW of Ha Noi, NE of Na Hang, 150-200m, leg. A. Napolov, I. Roma, 9-14.vi.1996, 1 male (ANLC).
 Distribution. Vietnam (Tuyen Quang and Vinh Phuc).
 Remarks. New provincial record for Tuyen Quang.
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 13, DOI: 10.5281/zenodo.5169363
Additional file of Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
Creators: name: Savi, Monia
name: Bocchi, Leonardo
name: Cacciani, Francesca
name: Rocchina Vilella
name: Buschini, Annamaria
name: Perotti, Alessio
name: Galati, Serena
name: Montalbano, Serena
name: Pinelli, Silvana
name: Frati, Caterina
name: Corradini, Emilia
name: Quaini, Federico
name: Ruotolo, Roberta
name: Stilli, Donatella
name: Zaniboni, Massimiliano
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file of Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
Molecular dynamics simulations and MM-GBSA reveal a novel small molecule against Flu A RNA-dependent RNA polymerase
Creators: name: Samir, Ahmed
name: Elshemey, Wael M.
name: Elfiky, Abdo A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Virology

description: The interaction between the C-terminal domain (CTD) of the polymerase acidic (PA) component of three Flu A RNA polymerases of different origins and three heptad repeats from human polymerase II CTD was computationally recreated. Then a unique pharmacological library was tested in order to target conserved active site residues in the three RNA-dependent RNA polymerase (RdRps) using a combination of molecular dynamics simulation and molecular docking. Results show that one compound (ZINC66032798) can effectively bind to the desired active site residues in each of the three RdRps. Hence, it may possess an inhibitory action by competing with human polymerase II CTD binding to the same active site of the viruses. The current in silico analysis suggests a promising novel lead to block Flu A RdRp, yet to be confirmed in the wet lab. It decreases the binding affinity of influenza A viruses to human polymerase II by 47.9%, 67.2%, and 28.0%, respectively.
Majorization and minimal energy on spheres
Creators: name: Musin, Oleg R.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Metric Geometry (math.MG)
subject: Information Theory (cs.IT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: In the present paper, we consider the majorization theorem (also known as Karamata's inequality) and the respective minima of the majorization (the so-called M-sets) for f-energy potentials of $m$-point configurations on the unit sphere. In particular, we show the optimality of regular simplexes, describe some M-sets of small cardinality, define and discuss spherical f-designs.
description: 18 pages
Making the Most Out of What You’re Already Doing
Creators: name: Espey, Molly
name: Espey, Molly
Publisher: name: Unknown
Year: 2013
Subjects: subject: Teaching/Communication/Extension/Profession
subject: Scholarship of teaching
subject: scholarship of learning
subject: economic education
subject: team based learning
subject: teaching of economics

description: The scholarship of teaching and learning entails systematic reflection and analysis of aspects of teaching or teaching methods and their impact on student learning. When effective teaching methods can be identified and replicated by others, scholarship shared through publication has the potential to enhance teaching and learning on a wider scale. Whether it is analysis of a small aspect of a single course or a complete overhaul of the course structure or method of delivery, the scholarship of teaching and learning has the potential to significantly impact higher education. This paper outlines five scholarship of teaching and learning projects undertaken during this author’s career.
MOESM1 of Which difficulties do GPs experience in consultations with patients with unexplained symptoms: a qualitative study
Creators: name: Houwen, Juul
name: Lucassen, Peter
name: Verwiel, Anna
name: Stappers, Hugo
name: Assendelft, Willem
name: Hartman, Tim
name: Dulmen, Sandra
Publisher: name: figshare
Year: 2019
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Interview guide: “What do you think of the consultation after watching it so far?” “What could you have done differently?”.
Discussion on the mechanism of Lingguizhugan Decoction in treating hypertension based on network pharmacology and molecular simulation technology
Creators: name: Dong, Qi
name: Huang, Yu-Jiao
name: Tao, Zhi-Yu
name: Huang, Han-Yue
name: Luo, Lin-Hui
name: Zhang, Ying-Qing
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: To explore the mechanism of Lingguizhugan Decoction in treating hypertension based on network pharmacology and molecular simulation. The active ingredients and potential targets were screened by the Systematic Pharmacological Analysis Platform of Traditional Chinese Medicine (TCMSP). Hypertension-related targets were obtained from OMIM and GeneCards databases. Common targets between drug and hypertension were screened in the Venny platform. A protein-protein interaction (PPI) network was constructed in the STRING database using intersection targets. Key targets in PPI network were analyzed by Cytoscape. R language program was used for Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, the binding abilities of the main active ingredients to critical targets were verified by molecular simulation. Naringenin, quercetin, kaempferol, and β-sitosterol in Lingguizhugan Decoction, and potential targets such as STAT3, AKT1, TNF, IL6, JUN, PTGS2, MMP9, CASP3, TP53, and MAPK3, were screened out. KEGG Enrichment analysis revealed that the common targets of Lingguizhugan Decoction and hypertension are mainly involved in the lipid and atherosclerosis signaling pathway, AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, and IL17 signaling pathway. The molecular simulation results showed that naringenin-MAPK3, quercetin-MMP9, quercetin-PTGS2, and quercetin-TP53 were the top four in the docking scores. Naringenin-MAPK3 and quercetin-MMP9 were stable, with binding free energies of −27.97 ± 1.41 kcal/mol and −21.15 ± 3.17 kcal/mol, respectively. The possible mechanism of Lingguizhugan Decoction in treating hypertension is characterized of multi-component, multi-target, and multi-pathway.
Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation
Creators: name: Richardson, Richard B.
name: Ainsbury, Elizabeth A.
name: Prescott, Christina R.
name: Lovicu, Frank J.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Computational Biology

description: Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed in relation to selected risk factors that induce PSCs (including atopy, diabetes, hypoparathyroidism, myopia, retinitis, solar radiation, steroid use, uveitis, vitrectomy and ionizing radiation). We particularly focused on ionizing radiation, as this is known to be a risk factor specific to PSCs. Based on an analysis of the reviewed material, we propose a detailed explanation of the etiology of PSCs. Lens epithelial cells (LECs) and lens fiber cells are normally hypoxic and therefore very sensitive to changes in oxidative stress, as quantified by the radiation oxygen effect. We hypothesize that the development of PSC opacities is a two-stage process. Stage I, early in life, is driven by risk factors that promote oxidative stress and ion-pump disruption, harming lens fibers and causing aberrant LECs to proliferate and ectopically migrate as Wedl cells (perhaps by processes associated with an epithelial to mesenchymal transition) to the posterior pole region. After a latent period, in Stage II, the development of PSCs advances mainly due to chronic inflammation and other premature aging-related mechanisms that promote mature vacuolar or plaque PSC. This two-stage hypothesis of PSC etiology accounts for risk factors, such as aging, diabetes and ionizing radiation, which directly affects LECs and the lens. In addition, these risk factors can damage other ocular regions, such as the retina and vitreous, that also indirectly contribute to the development of PSCs. It is possible that the incidence of PSCs may be reduced by reversing the effects of Stage I through various means, including ocular antioxidants.
Unidirectional Reflectionless Transmission for Two-Dimensional $\mathcal{PT}$-symmetric Periodic Structures
Creators: name: Yuan, Lijun
name: Lu, Ya Yan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Unidirectional reflectionless propagation (or transmission) is an interesting wave phenomenon observed in many $\mathcal{PT}$-symmetric optical structures. Theoretical studies on unidirectional reflectionless transmission often use simple coupled-mode models. The coupled-mode theory can reveal the most important physical mechanism for this wave phenomenon, but it is only an approximate theory, and it does not provide accurate quantitative predictions with respect to geometric and material parameters of the structure. In this paper, we rigorously study unidirectional reflectionless transmission for two-dimensional (2D) $\mathcal{PT}$-symmetric periodic structures sandwiched between two homogeneous media. Using a scattering matrix formalism and a perturbation method, we show that real zero-reflection frequencies are robust under $\mathcal{PT}$-symmetric perturbations, and unidirectional reflectionless transmission is guaranteed to occur if the perturbation (of the dielectric function) satisfies a simple condition. Numerical examples are presented to validate the analytical results, and to demonstrate unidirectional invisibility by tuning the amplitude of balanced gain and loss.
description: 10 pages, 5 figures
Does Access to Finance Matter in Microenterprise Growth? Evidence from Bangladesh
Creators: name: Khandker, Shahidur R.
name: Samad, Hussain
name: Ali, Rubaba
name: Khandker, Shahidur R.
name: Samad, Hussain
name: Ali, Rubaba
Publisher: name: Unknown
Year: 2013
Subjects: subject: Community/Rural/Urban Development
subject: Financial Economics
subject: International Development
subject: Micro-enterprise development
subject: access to finance

description: In less-developed economies such as Bangladesh where the farm sector is the major source of employment and income, the rural nonfarm sector (RNF) often as an additional source of income increasingly plays an important role in fostering the development of the rural economy, and microenterprise activities constitute a significant share of this sector. However, the key to participation in such activities requires investment and access to adequate funds. This paper investigates the role of access to finance in promoting efficiency and growth of microenterprise activities. Our findings suggest that the households engaged in microenterprise activities besides farm and other nonfarm activities are much better off (in terms of income, expenditure and poverty) than those who do not engage in such activities. However, fewer than 10 percent of the enterprises have access to institutional finance (formal banks or microcredit) although the rate of return on microenterprise investments is more than sufficient (36 percent per year) to repay institutional loans. Our findings suggest that credit constraints may reduce the enterprise profit margin by as much as 13.6 percent per year. As such, further in-depth studies should explore why microfinance institutions (MFIs) have not been more helpful in promoting microenterprise growth in Bangladesh.
Additional file 4 of Placenta previa with posterior extrauterine adhesion: clinical features and management practice
Creators: name: Nagase, Yoshikazu
name: Matsuzaki, Shinya
name: Endo, Masayuki
name: Takeya Hara
name: Okada, Aiko
name: Mimura, Kazuya
name: Hiramatsu, Kosuke
name: Kakigano, Aiko
name: Nakatsuka, Erika
name: Miyake, Tatsuya
name: Takiuchi, Tsuyoshi
name: Ueda, Yutaka
name: Tomimatsu, Takuji
name: Kimura, Tadashi
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 4: Table S1. Patterns of magnetic resonance images according to the presence or absence of findings suspecting PAS.
Agriculture's Supply and Demand for Energy and Energy Products
Creators: name: Beckman, Jayson F.
name: Borchers, Allison
name: Jones, Carol
name: Beckman, Jayson F.
name: Borchers, Allison
name: Jones, Carol
Publisher: name: Unknown
Year: 2013
Subjects: subject: Crop Production/Industries
subject: Farm Management
subject: Resource /Energy Economics and Policy
subject: energy
subject: fertilizer
subject: pesticides
subject: fuel
subject: biofuels
subject: renewable energy
subject: ARMS

description: Rising energy prices and changing energy and environmental policies have transformed the relationship between the energy and agriculture sectors. Traditionally, the relationship has been one-way, with agriculture using energy products as an input in production; during the past decade, however, the energy sector’s use of agricultural products as renewable-fuel feedstocks has increased substantially. This report examines both sector and farm-level responses to changing market and policy drivers such as the increased production of biofuel crops and other sources of renewable energy, together with changes in production practices to economize on energy-based inputs like fertilizer. We provide insight into how farmers have adapted to the changes and update and provide new data on the evolving linkages between the energy and agricultural sectors.
RX J004717.4-251811: The first eclipsing X-ray binary outside the Local Group
Creators: name: Pietsch, W.
name: Haberl, F.
name: Vogler, A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The X-ray source RX J004717.4-251811 in the nearby starburst galaxy NGC 253 was found to undergo changes from a low to a high state twice, during an XMM-Newton EPIC observation in December 2000 and also during a Chandra observation one year earlier. These transitions are interpreted as egresses from eclipses of a compact object in a high mass X-ray binary system (HMXB). The phase of eclipse egress during the Chandra observation is given by barycenter corrected MJD 51539.276+-0.006 and the binary period determined to p = (352.870+-0.012) d / n by the time difference between the two egresses and number n of periods in-between. Allowed periods may be further constrained by additional XMM-Newton, Chandra, ROSAT, and Einstein observations resulting in only seven acceptable periods with 1.47024 d and 3.20793 d most promising. No significant regular pulsations of the source in the range 0.3-1000 s were found. Fluctuations on time scales of 1000 s were observed together with extended intervals of low intensity. The energy spectrum during the bright state can best be described by an absorbed flat power law (NH=1.9x10^21 cm^-2, Gamma=1.7). In the bright state the source luminosity is 4x10^38 erg/s (0.5--5 keV), just compatible with the Eddington luminosity of a 1.4 M_sun neutron star. A possible optical identification is suggested. RX J004717.4-251811 parameters are compared to other eclipsing X-ray binaries (XRBs).
description: 9 pages including 5 figures, accepted for publication in A&A
Computational exploration of Zika virus RNA-dependent RNA polymerase inhibitors: a promising antiviral drug discovery approach
Creators: name: Mishra, Prabhu Chandra
name: Alanazi, Amer M.
name: Panda, Siva Prasad
name: Alam, Aftab
name: Dubey, Amit
name: Jha, Saurabh Kumar
name: Kamal, Mohammad Amjad
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The emergence of the Zika virus, which belongs to the Flaviviridae family, became a significant worldwide health issue due to its link with severe neurological complications. The RNA-dependent RNA polymerase (RdRp) of the Zika virus plays a significant part in the replication of the virus and is considered a promising candidate for antiviral drug identification. In this study, we employed computer-based drug discovery approaches to identify potential natural compounds that could act as inhibitors against the RdRp protein of the Zika virus. A comprehensive virtual screening strategy was implemented using the MTiOpenScreen webserver to identify natural compounds from the NP-Lib database. Four natural compounds having the ZINC ID – ZINC000253499147, ZINC000299817665, ZINC000044404209, and ZINC000253388535 were selected based on the binding score revealed during virtual screening. Molecular docking simulations of these selected compounds and reference compounds were performed to assess the binding affinities and the molecular bonds formed during the docking. Additionally, molecular dynamics (MD) simulations, endpoint free binding energy calculation and principal component analysis (PCA) were performed to evaluate the stability and dynamics of the protein-ligand complexes. These compounds exhibited favourable binding energies and formed stable interactions within the active site of the RdRp protein. Moreover, the molecular dynamics simulations revealed the robustness of the protein-ligand complexes, suggesting the potential for sustained inhibition. These findings provide valuable insights for the design and development of novel therapeutic interventions against Zika virus infection. Further experimental validation and optimization of the identified compounds are warranted to advance their potential translation into effective antiviral drugs.