cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of the matter density uncertainty on the dark energy reconstruction
Creators: name: Avelino, P. P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we study the impact of the fractional matter density uncertainty in the reconstruction of the equation of state of dark energy. We consider both standard reconstruction methods, based on the dynamical effect that dark energy has on the expansion of the Universe, as well as non-standard methods, in which the evolution of the dark energy equation of state with redshift is inferred through the variation of fundamental couplings such as the fine structure constant, $α$, or the proton-to-electron mass ratio, $μ$. We show that the negative impact of the matter density uncertainty in the dark energy reconstruction using varying couplings may be very small compared to standard reconstruction methods. We also briefly discuss other fundamental questions which need to be answered before varying couplings can be successfully used to probe the nature of the dark energy.
description: 6 pages, 3 figures, published version
การออกแบบส่วนต่อประสานผู้ใช้สำหรับแอปพลิเคชันควบคุมฟาร์มอัจฉริยะ กรณีศึกษาฟาร์มไม้ดอก
Creators: name: ลักษณ์นารา จันทรารมย์
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2564
Subjects: การออกแบบส่วนต่อประสานผู้ใช้แบบกราฟิก
ฟาร์มอัจฉริยะ
แอปพลิเคชันควบคุมฟาร์มอัจฉริยะ
ฟาร์มไม้ดอกอัจฉริยะ

description: วารสารมหาวิทยาลัยศิลปากร, 41, 4, 65-76
Pinalites: Optical properties and Quantum Magnetism of Heteroanionic A$_3$MO$_5$X$_2$ Compounds
Creators: name: Hirai, Daigorou
Publisher: name: arXiv
Year: 2025
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Heteroanionic compounds, which contain two or more types of anions, have emerged as a promising class of materials with diverse properties and functionalities. In this paper, I review the experimental findings on Ca3ReO5Cl2 and related com-pounds that exhibit remarkable pleochroism and novel quantum magnetism. I discuss how the heteroanionic coordination affects the optical and magnetic properties by modulating the d-orbital states of the transition metal ions and then compare these materials with other heteroanionic and monoanionic compounds and highlight the potential of A3MO5X2 materials for future exploration of materials and phenomena.
description: 12 pages, 3 figures, 1 table
ความสัมพันธ์ระหว่างการจัดการโลจิสติกส์กับผลการดำเนินงานของอุตสาหกรรมยานยนต์ในประเทศไทย
Creators: name: ธิญาดา พิชญาศุภกุล
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2564
Subjects: การจัดการภายใน
การจัดการโลจิสติกส์
ผลการดำเนินงานทางธุรกิจ

description: วารสารมหาวิทยาลัยศิลปากร, 41, 4, 77-89
Artificial activation of APETALA1 using recombinant proteins and cell penetrating peptides
Creators: name: Joyce, William David Leonard Brierley
Publisher: name: Imperial College London
Year: 2019

description: This thesis reports a novel method for the artificial activation of reproductive development in Arabidopsis. In this way, reproductive development was triggered by an exogenous delivery of the recombinant florigen protein, Flowering Locus T (FT), at the shoot apical meristem in order to artificially activate Apetala 1 (AP1), the major floral homeotic gene. This was assessed by large phenotyping experiments after protein treatment. In addition, a transgenic reporter was created, using the promoter of AP1 and GFP to assess the artificial activation of AP1. Furthermore, this thesis reports the action of cell penetrating peptide uptake (namely R9, Tat, TP10 and pVEC) into plant tissue. An in-depth investigation into R9 uptake revealed mechanistic details in particular the initial interaction of R9 with the cell wall to create a high local peptide concentration in proximity to the membrane. Further studies reported the successful uptake of R9 into mesophyll cell culture, protoplasts and apical meristems, including the development of a novel quantitative assessment for R9 uptake into root tips. Tool development notably included the covalent attachment of R9 and Tat to FT and Sortagging, a novel labeling method enabling the fluorescent tracking of proteins in planta using confocal microscopy. Superior uptake was reported for FT-Tat over FT-R9 in cell culture and FT-Tat uptake was reported in the shoot apical meristem. This is the first example of covalent CPP-mediated delivery of a functional protein to the apical tissue. This study reports progress en route to developing a universal tool for flowering time control in agriculture. It is the first reported example of an exogenous macromolecular treatment with a recorded biological effect in planta and as such is a novel approach to target and control AP1 expression.
Novel tools and strategies of nanopore single-molecule biosensing
Creators: name: Ren, Ren
Publisher: name: Imperial College London
Year: 2019

description: Nanopores have been proved to be promising analytical platforms for label-free single-molecule biosensing. However, the practical application of nanopores, such as early stage diagnosis tools or the DNA sequencing tools, is restricted by several functional defects. The main aim of this work is to explore multiple approaches to improve the sensitivity and selectivity of a nanopipette based nanopore sensing, by a combination of field-effect transistors or molecular carriers. In the first part of the thesis, a new class of nanoscale sensors – dubbed a nanopore extended field-effect transistor (nexFET) – is fabricated to control and selectively sense the biomolecules. Through real-time feedback controlling electrodeposition, a tuneable polypyrrole nanopore can be formed on a carbon-coated double-barrel nanopipette tip with one barrel filled with carbon nanoelectrodes. The generated nexFET displays outstanding FET performance and pH sensitivity. Combining the advantages of nanopore single-molecule sensing, field-effect transistors, and recognition chemistry, the nexFETs are subsequently employed to probe DNA and protein molecules. By controlling the gate voltage of the nexFET, the transport of DNA can be improved comprehensively; for example, a higher throughput, a longer dwell time, and a higher signal-to-noise ratio can be achieved. The selectivity of the nexFET can be further improved by functionalising with embedded receptors. Attention is then focussed to explore novel strategies for selective biomolecular sensing using nanopipettes, and molecular carriers and probes. Here, I design probes based on the dimerisation of gold nanoparticles (NP), which can be used for the detection of biological targets. Two strategies are employed: 1) aptamer-modified NP dimers are used to target biomarkers, and 2) antibody-modified NP monomers dimerise and self-assemble based on the binding of an antigen target. Importantly, we demonstrate that nanopore sensing can be utilised with both strategies to quantify bound analytes from unbound ones and, in the process, perform single-molecule binding assays. In summary, multiple approaches including functionalised nanopores, novel molecular carriers, and novel molecular probes were designed and developed. As they can address various limitations of nanopore-based biosensors, these improved methods are expected to pave the way for the practical application of nanopores in early diagnostics and therapeutics.
การสร้างสรรค์การแสดงเพื่อส่งเสริมอัตลักษณ์ทางวัฒนธรรมของอำเภออู่ทอง จังหวัดสุพรรณบุรี
Creators: name: ณัฐภา นาฏยนาวิน
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2564
Subjects: การสร้างสรรค์การแสดง
อัตลักษณ์
วัฒนธรรม
อำเภออู่ทอง จังหวัดสุพรรณบุรี

description: วารสารมหาวิทยาลัยศิลปากร, 41, 4, 90-100
Exchange and correlation energy functionals for two-dimensional open-shell systems
Creators: name: Rasanen, E.
name: Pittalis, S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider density functionals for exchange and correlation energies in two-dimensional systems. The functionals are constructed by making use of exact constraints for the angular averages of the corresponding exchange and correlation holes, respectively, and assuming proportionality between their characteristic sizes. The electron current and spin are explicitly taken into account, so that the resulting functionals are suitable to deal with systems exhibiting orbital currents and/or spin polarization. Our numerical results show that in finite systems the proposed functionals outperform the standard two-dimensional local spin-density approximation, still performing well also in the important limit of the homogeneous two-dimensional electron gas.
title: Ατμοσφαιρική ρύπανση και σκλήρυνση κατά πλάκας στο γυναικείο πληθυσμό
title: Air pollution and multiple sclerosis in the female population
titleType: AlternativeTitle
Creators: name: Σταυράκη, Λεωνία Ελεωνόρα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Σκλήρυνση κατά πλάκας
Ατμοσφαιρική ρύπανση
Γυναίκες
Ατμοσφαιρικοί ρύποι
Πολλαπλή σκλήρυνση
Αιωρούμενα σωματίδια

description: Τα τελευταία χρόνια, οι ανθρώπινες δραστηριότητες επιβαρύνουν το περιβάλλον και δημιουργούν διαφορετικές μορφές ρύπανσης (ατμοσφαιρική, υδάτων, εδαφική, ηχορύπανση κτλ.). Ως εκ τούτου, η ατμοσφαιρική ρύπανση επιβαρύνει το περιβάλλον και την ανθρώπινη υγεία με άμεσες και έμμεσες επιπτώσεις. Η Σκλήρυνση κατά Πλάκας (ΣκΠ) είναι μια χρόνια νευροεκφυλιστική νόσος με αυτοάνοση φυσιοπαθολογία του κεντρικού νευρικού συστήματος. Επιστημονικές μελέτες υποστηρίζουν ότι όσο περνάνε τα χρόνια, οι ασθενείς που νοσούν με ΣκΠ αυξάνονται. Ωστόσο, δεν υπάρχει μια ακριβής αιτία που να είναι επιστημονικά αποδεκτή ότι δημιουργεί ή αναπτύσσει τη ΣκΠ ή που να δημιουργεί εκφυλισμό στους ασθενείς με προϋπάρχουσα ΣκΠ. Παρόλο που δεν είναι μία η γενεσιουργός αιτία, διαφορετικά αίτια έχουν συσχετιστεί με την επιδείνωση των συμπτωμάτων της ΣκΠ, όπως για παράδειγμα το κάπνισμα, η παχυσαρκία, η έλλειψη βιταμίνης D, ως αποτέλεσμα της μειωμένης ηλιοφάνειας. Επιπλέον, έρευνες υποδεικνύουν το φύλο ως παράγοντα κινδύνου. Συγκεκριμένα, οι γυναίκες έχουν πάνω από διπλάσιο ποσοστό νόσησης. Στη βιβλιογραφία, υπάρχουν μελέτες που βρίσκουν θετική, ουδέτερη ή αρνητική συσχέτιση μεταξύ της ΣκΠ και της ατμοσφαιρικής ρύπανσης. Παρατηρείται διάσταση επιστημονικών δεδομένων αναφορικά με τη σχέση της ατμοσφαιρικής ρύπανσης και της ΣκΠ. Επιπλέον, τα δεδομένα είναι ελάχιστα και χρειάζεται περαιτέρω μελέτη για την ενίσχυση και την επιστημονική εξέλιξη της έρευνας που αφορά την ΣκΠ. Η παρούσα μεταπτυχιακή διπλωματική εργασία έχει ως σκοπό, την ανασκόπηση της υπάρχουσας βιβλιογραφίας για τη σχέση της ατμοσφαιρικής ρύπανσης τόσο στην εμφάνιση, όσο και στην πρόγνωση της ΣκΠ στο γυναικείο πληθυσμό, σε εθνικό και διεθνές επίπεδο.
Time resolved X-ray absorption spectroscopy in Poly(3-hexylthiophene)
Creators: name: Garratt, Douglas
Publisher: name: Imperial College London
Year: 2020

description: This thesis details the extension of time resolved x-ray absorption spectroscopy to the study of organic photovoltaic (OPV) materials. These materials have attracted signi cant research interest due to the potential to provide low cost, thin, flexible solar cells which can be solution processed. Here, we apply a tabletop, high harmonic generation based soft x-ray source to static and time resolved x-ray absorption spectroscopy of poly(3-hexylthiophene) (P3HT), a widely studied material in OPV research. The bandwidth of the attosecond HHG source and x-ray detection is sufficient to measure the x-ray absorption spectrum at the sulfur L edge (165 - 230 eV) and carbon K edge (284 eV) simultaneously. This is combined with a 15 fs pump pulse at 2.25 eV to probe the dynamics after photoexcitation of the pi - pi* transition relevant to solar energy conversion. Particular attention is paid to characterising and minimising the effect of pump induced thermal heating and sample damage which can obscure dynamical signals in these highly photosensitive thin film materials with low thermal conductivity. To this end we characterise the temperature dependence of the x-ray absorption spectrum of P3HT up to 225 C and propose and implement a methodology for minimising the effect of pump induced heating on the experimental signal, without compromising the signal to noise ratio of the measurement. At the sulfur L2,3 edge no photoinduced changes in the x-ray absorption spectrum are observed within the experimental error, after accounting for thermal effects. At the carbon K edge, transient differential absorption features are observed in the vicinity of the carbon 1s - pi* transition. These are characterised over the first 100 fs following photoexcitation. Preliminary interpretation of the signal is discussed.
New Instability Results for High Dimensional Nearest Neighbor Search
Creators: name: Giannella, Chris
Publisher: name: arXiv
Year: 2009
Subjects: subject: Databases (cs.DB)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Consider a dataset of n(d) points generated independently from R^d according to a common p.d.f. f_d with support(f_d) = [0,1]^d and sup{f_d([0,1]^d)} growing sub-exponentially in d. We prove that: (i) if n(d) grows sub-exponentially in d, then, for any query point q^d in [0,1]^d and any epsilon>0, the ratio of the distance between any two dataset points and q^d is less that 1+epsilon with probability -->1 as d-->infinity; (ii) if n(d)>[4(1+epsilon)]^d for large d, then for all q^d in [0,1]^d (except a small subset) and any epsilon>0, the distance ratio is less than 1+epsilon with limiting probability strictly bounded away from one. Moreover, we provide preliminary results along the lines of (i) when f_d=N(mu_d,Sigma_d).
Actual and anticipated reactions to engaging with and dismissing political opponents : who and where they come from, and why they matter
Creators: name: Heltzel, Gordon
Publisher: name: University of British Columbia
Year: 2023

description: Growing political polarization has fueled calls for people to constructively engage with opponents and better understand their perspectives rather than dismissively avoiding or condemning them. People who heed these calls may be doing their part to benefit democracy, but what about their reputations—will their behavior elevate them or abase them in their allies’ eyes? My dissertation reports ten studies answering this and related questions. Building on my MA thesis, which finds that people usually like allies who constructively engage with opponents’ views, Chapter 2’s Studies 1 and 2 examined why they hold this preference and when it is most likely to emerge. In Chapter 3, Studies 3 and 4 found a case when people prefer the opposite: U.S. Senators’ tweets received more positive feedback when they dismissed opponents compared to engaging with them. Studies 5 and 6 (and Appendix Studies S1-S4) test various explanations for this contradictory pattern, finding that Twitter popularity represents the genuine preferences of a small group of active users with unusual attitudes, as well as inauthentic preferences expressed by everyone else. Drawing on this observation that popular opinion is not represented on (social) media, Chapter 4 considered whether people fail to realize that their allies endorse cross-party engaging. Indeed, Studies 7 and 8 find that people mistakenly think they are alone in preferring allies who engage over those who dismiss. I theorized that perceived polarization causes these misperceptions, but Studies 9 and 10 found that reducing perceived polarization does not reduce misperceptions nor encourage people to engage with opposing views. This work on one hand highlights reputational benefits of engaging with opposing views; on the other, it suggests social media distorts these benefits, and people generally fail to realize them. At the same time, it leaves open how interventions might motivate engagement with opposing views.
Thermal Geo-axions
Creators: name: Davoudiasl, Hooman
name: Huber, Patrick
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We estimate the production rate of axion-type particles in the core of the Earth, at a temperature T~5000K. We constrain thermal geo-axion emission by demanding a core-cooling rate less than 100K/Gyr, as suggested by geophysics. This yields a "quasi-vacuum" (unaffected by extreme stellar conditions) bound on the axion-electron fine structure constant α_a^{QV} < 10^{-18}, stronger than the existing accelerator (vacuum) bound by 4 orders of magnitude. We consider the prospects for measuring the geo-axion flux through conversion into photons in a geoscope; such measurements can further constrain α_a^{QV}.
description: 4 pages, 1 figure
The experiential dimension of sustainable materials
Creators: name: Bin Bahrudin, Fadzli Irwan
Publisher: name: Imperial College London
Year: 2019

description: One of the stakeholders’ prominent efforts in pursuing the circular economy is the development and utilisation of sustainable materials. At present, however, little is known about how consumers experience these materials. Thus, this research aims to investigate the experiential dimension in user-sustainable material interaction. Sustainable materials were found to consist of multiple types of materials (e.g. organic) that are made from diverse types of resources (i.e. virgin and waste). Notably, the materials are complemented with lifecycle material information. A set of sustainability attributes (e.g. abundant) were identified as the essence of the information. A thorough analysis of material information has enabled the concept of material biography to be established along with a comprehensive set of biographical descriptors encompassing the lifecycle of materials. Descriptors related to material-origin such as the ‘object origin’ (e.g. yoghurt cups) and ‘substance origin’ (e.g. recycled plastic) are commonly used to narrate particular stories and make sustainability claims. Users’ evaluation of products made of sustainable materials complemented with material-origin information includes a new type of appraisal termed as ‘systemic’. This appraisal reflects the perceived lifecycle impact of materials. A further study demonstrates that conflicting emotions on the ‘systemic’ appraisal and other appraisal themes of the materials results in users feeling ambiguous and averse to using the materials. Nevertheless, a coherent sustainability claim conveyed by multiple biographical descriptors is proven to improve the perceived instrumental quality and aesthetic quality of the materials. Therefore, this thesis argues that the experiential dimension of sustainable materials is built upon their tangible and intangible elements. The sensorial properties of materials is a tangible stimulus, whereas material biographical information is an intangible stimulus influential in steering consumers’ perception. Adding material biographical information in the form of a compelling narrative to products can be considered an efficient strategy to provide a meaningful user-sustainable material interaction.
title: Η εφαρμογή του συμμετοχικού μοντέλου διοίκησης σε ένα κέντρο υγείας
title: The application of the participative management model in a health center
titleType: AlternativeTitle
Creators: name: Νασιούλη, Άννα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Πρωτοβάθμια Φροντίδα Υγείας
Κέντρο υγείας
Συμμετοχικό μάνατζμεντ
Συστήματα υγείας

description: Στην σύγχρονη εποχή το άτομο δεν περιορίζεται απλά στην επιβίωση του, αλλά επιζητά την μέγιστη προσωπική ευημερία, η οποία επιτυγχάνεται με την διατήρηση ενός υγιούς επιπέδου ζωής. Η επιδίωξη της κάλυψης των αναγκών υγείας αποτέλεσε ένα φαινόμενο που απασχόλησε τον άνθρωπο από την δημιουργία του. Μελετώντας την ιστορική εξέλιξη της δημιουργίας συστημάτων υγείας, διαπιστώνεται ότι υποχρεωτικά ο άνθρωπος έπρεπε να προσαρμοστεί στις συνθήκες προκειμένου να επιβιώσει. Μέσα από τις αντίξοες συνθήκες της πανδημίας του Covid_19 προβάλλεται μια νέα ευκαιρία για αλλαγή της επικρατούσας φιλοσοφίας. Διαπιστώνεται ότι το συλλογικό υπερτερεί έναντι του ατομικού. Η ανάγκη της μετάβασης του συστήματος διοίκησης των υπηρεσιών υγείας από τα απαρχαιωμένο γραφειοκρατικό μοντέλο στη συμμετοχική διοίκηση είναι επιτακτική. Παγκόσμια τάση αποτελεί η στροφή προς την παροχή ισότιμων, ολοκληρωμένων υπηρεσιών υγείας σε τοπικό επίπεδο και η καλλιέργεια κουλτούρας πρόληψης και υγείας στον πληθυσμό. Για τον λόγο αυτό τα Κέντρα Υγείας που ανήκουν στην Πρωτοβάθμια Φροντίδα, αναλαμβάνουν πρωταγωνιστικό ρόλο μιας και αποτελούν το σημείο εισόδου των ασθενών στις υπηρεσίες υγείας. Ο συνδυασμός εφαρμογής του συμμετοχικού μοντέλου διοίκησης, στη βάση των υπηρεσιών υγείας που αποτελούν τα Κέντρα Υγείας, θα μπορούσε να επιφέρει θεαματικά αποτελέσματα με επίδραση σε ολόκληρο το σύστημα υγείας, στον βαθμό ικανοποίησης των ασθενών και των μελών του οργανισμού.
Thermalization through parton transport
Creators: name: Zhang, Bin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A radiative transport model is used to study kinetic equilibration during the early stage of a relativistic heavy ion collision. The parton system is found to be able to overcome expansion and move toward thermalization via parton collisions. Scaling behaviors show up in both the pressure anisotropy and the energy density evolutions. In particular, the pressure anisotropy evolution shows an approximate alpha_s scaling when radiative processes are included. It approaches an asymptotic time evolution on a time scale of 1 to 2 fm/c. The energy density evolution shows an asymptotic time evolution that decreases slower than the ideal hydro evolution. These observations indicate that partial thermalization can be achieved and viscosity is important for the evolution during the early longitudinal expansion stage of a relativistic heavy ion collision.
description: Presented at the 10th International Conference on Nucleus-Nucleus Collisions (NN2009), Beijing, China, 16-21 Aug 2009
A simple rule for axon outgrowth and synaptic competition generates realistic connection lengths and filling fractions
Creators: name: Kaiser, Marcus
name: Hilgetag, Claus C.
name: van Ooyen, Arjen
Publisher: name: arXiv
Year: 2009
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Neural connectivity at the cellular and mesoscopic level appears very specific and is presumed to arise from highly specific developmental mechanisms. However, there are general shared features of connectivity in systems as different as the networks formed by individual neurons in Caenorhabditis elegans or in rat visual cortex and the mesoscopic circuitry of cortical areas in the mouse, macaque, and human brain. In all these systems, connection length distributions have very similar shapes, with an initial large peak and a long flat tail representing the admixture of long-distance connections to mostly short-distance connections. Furthermore, not all potentially possible synapses are formed, and only a fraction of axons (called filling fraction) establish synapses with spatially neighboring neurons. We explored what aspects of these connectivity patterns can be explained simply by random axonal outgrowth. We found that random axonal growth away from the soma can already reproduce the known distance distribution of connections. We also observed that experimentally observed filling fractions can be generated by competition for available space at the target neurons--a model markedly different from previous explanations. These findings may serve as a baseline model for the development of connectivity that can be further refined by more specific mechanisms.
description: 31 pages (incl. supplementary information); Cerebral Cortex Advance Access published online on May 12, 2009
Chemical constituents from Oldenlandia diffusa and their cytotoxic effects on human cancer cell lines
Creators: name: Lv, Yi
name: Wang, Ying
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Oldenlandia diffusa is an important Chinese traditional medicine with various biological activities such as anti-tumor, anti-inflammatory, anti-oxidant, antibacterial, neuroprotective and hepatoprotective effects. During our course of finding novel compounds from O. diffusa, two new alternariol derivatives named 9-O-(trans-p-coumaroyl)-alternariol (1), 9-O-(trans-caffeoyl)-alternariol (2), together with six known compounds (3-8) were isolated. Their structures were established on the basis of spectroscopic and physicochemical analysis. All isolates were evaluated for in vitro cytotoxic activities on MCF-7, HepG2, A549 and A2780 cancer cells. As a result, new compounds 1 and 2 exhibited potent cytotoxic activities on A2780 cancer cells with IC50 values of 3.1 and 9.4 μM, respectively. And a conclusion was deduced that the p-coumaroyl or caffeoyl moiety could greatly increased the cytotoxic activity of alternariol on cancer cells.
Investigating reaction systems for high-temperature thermochemical energy storage and discharge integrated with concentrated solar power
Creators: name: Ghosh, Shiladitya
Publisher: name: Imperial College London
Year: 2020

description: In this thesis, two distinct reversible chemical reactions were studied for thermochemical energy storage (TCES) applications with a focus on integration with concentrated solar power (CSP): the reversible hydration of calcium oxide with steam and the redox behavior of certain copper manganese mixed metal oxides. A holistic investigation approach was employed encompassing the study of reaction kinetics, reactor design, process configuration, and the performing of a techno-economic assessment. Kinetic data for the reactions was experimentally obtained under fluidized conditions through this work as well as from recent literature to account for the potential impacts of reaction cycling stresses on the material integrity and reactive performance of the chosen material specifications. For exploring the potential of advanced large scale technologies that allow for continuous operation, fluidized bed reactor designs were then also used for evaluating the considered systems to assess the efficiency and effectiveness of long term and high volume energy storage processes using these reactions that allow for intermittent renewable energy sources such as solar to have stable energy production outputs over extended periods of time. Detailed flowsheet designs were then constructed and evaluated at steady-state based on hypothetical solar tower CSP plants at 120 MWth scale incorporating either of the two TCES reaction systems and appropriate power generation cycles; a steam Rankine cycle and a supercritical CO2 Brayton cycle were designed for the calcium oxide and copper manganese oxide energy discharging systems respectively. These flowsheets were then parametrically simulated with time variation under several operating scenarios based on historical solar irradiation data for Seville as a case study location and the performance of standalone cyclic storage and discharge cycles and standalone continuous discharging modes were evaluated in terms of technical performance criteria. Lastly a wide-ranging techno-economic assessment was performed for the two CSP-TCES plant designs by assessing their costs of energy storage and electricity generation and the variations in these figures as a result of varying operating schedules, weather, and geographical location. The overall cost estimates were then benchmarked against those of alternative clean energy storage and power generation technologies to assess the forecasted economic viability of advanced TCES plant designs while the materials and the technology both continue to steadily develop.
Myomectomy during pregnancy; diagnostical dilemmas: two case reports and a systematic review of the literature
Creators: name: Diakosavvas, Michail
name: Angelou, Kyveli
name: Fasoulakis, Zacharias
name: Kathopoulis, Nikolaos
name: Zacharakis, Dimitris
name: Blontzos, Nikolaos
name: Antsaklis, Panos
name: Haidopoulos, Dimitrios
name: Daskalakis, George
name: Rodolakis, Alexandros
name: Theodora, Marianna
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Myomectomy in pregnancy, until this day, remains very controversial. We present two cases of successful antepartum myomectomies performed in the second trimester of gestation. In both cases, the initial suspected origin of these tumours was the ovaries. However, as it was shortly after confirmed, since both women underwent laparotomy, the diagnosis of these masses was uterine fibroids. Both cases resulted on the live birth of two healthy infants via caesarean section. Secondarily, we conducted a thorough review of current data of myomectomies performed during pregnancy, including the characteristics and diagnosis of the myomas of pregnant women, the surgical details and complications, along with the outcomes of these gestations. Overall, the analysis of cases published in international literature, suggests that the surgical removal of myomas during pregnancy can be considered safe, given certain indications and considerations. Our review comprises of 71 women undergoing excision of fibroids during pregnancy. Only three cases ended in a miscarriage while the remaining 68 resulted in a second or third trimester delivery. However, the data concerning the safety of the procedure are scarce and originate mostly from case reports. Thus, conclusions on the exact maternal and obstetrical complication rates cannot be drawn.
ПОРЯДОК И МЕХАНИЗМ ПРИМЕНЕНИЯ МЕРЫ ПРЕСЕЧЕНИЯ В ВИДЕ ЗАКЛЮЧЕНИЯ ПОД СТРАЖУ ИЛИ ДОМАШНЕГО АРЕСТА
Creators: name: Рустамова, Адибахон
Publisher: name: Zenodo
Year: 2025

description: В статье рассматриваются актуальные тенденции развития уголовно-процессуальной политики в сфере применения мер пресечения, особое внимание уделяется дифференциации правового регулирования в отношении лиц, подозреваемых и обвиняемых в совершении преступлений в сфере предпринимательской и иной экономической деятельности. Анализируются основания и цели применения мер пресечения, включая заключение под стражу, а также международно-правовые аспекты и тенденции гуманизации и ужесточения уголовно-процессуального законодательства. Подчеркивается формирование специального правового режима применения мер пресечения к субъектам экономической деятельности, что вызывает дискуссии в научной среде. Разработаны предложения, направленные на расширение применения альтернативных заключению под стражу мер пресечения по экономическим преступлениям и усиление судебного контроля. В заключение отмечается избирательность современной уголовно-процессуальной политики и прогнозируются дальнейшие изменения в данной области.
Ownership Composition and the Management of Family-Owned Businesses in the South-East, Nigeria
Creators: name: Christopher O. Nwonu
name: Ibedu Onyebuchi Kevin
Publisher: name: Zenodo
Year: 2023
Subjects: Ownership Composition, Management and Family-owned Business

description: This study examined ownership composition and the management of family-owned businesses in South-East, Nigeria. Descriptive survey method based on primary and secondary sources of data collection was adopted. Data was obtained from primary and secondary sources. Primary data was gathered through questionnaire while the secondary data was gathered from a review of several research publications, annual reports, articles, textbooks, unpublished thesis, journals and internet sources related family businesses. The study population consisted of 43,868 family-owned businesses. The sample size is 554 determined using Cochran (1963) statistical formula. Analyses were carried out using simple descriptive statistics organized and presented in tables, frequency and simple percentages. At the inferential level of statistical analyses, the hypothesis was subjected to double-test using Pearson Product Moment Correlation Coefficient and Simple Linear Regression. To establish whether an outcome is statistically significant, the researcher set up a 5% significance level while a 95% confidence level was applied and tested at 5% (p-value ≤ 0.05) alpha level. All analyses were carried out in SPSS 20.0. The study found that the nature of ownership composition on the management in family-owned businesses has a significant relationship with a coefficient of 0.957 which is statistically significant with t = 4.723. The study concludes that the nature of ownership composition significantly affects the management of family-owned businesses in the South-East, Nigeria. The study recommends a separation of ownership and management so that experienced and professionals can be injected to manage the businesses to success
Holographic Gauge Mediation
Creators: name: Benini, Francesco
name: Dymarsky, Anatoly
name: Franco, Sebastian
name: Kachru, Shamit
name: Simic, Dusan
name: Verlinde, Herman
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss gravitational backgrounds where supersymmetry is broken at the end of a warped throat, and the SUSY-breaking is transmitted to the Standard Model via gauginos which live in (part of) the bulk of the throat geometry. We find that the leading effect arises from splittings of certain "messenger mesons," which are adjoint KK-modes of the D-branes supporting the Standard Model gauge group. This picture is a gravity dual of a strongly coupled field theory where SUSY is broken in a hidden sector and transmitted to the Standard Model via a relative of semi-direct gauge mediation.
description: 43 pages, 6 figures
Oxygen utilisation during exercise – a potential therapeutic target in chronic obstructive pulmonary disease
Creators: name: Pavitt, Matthew
Publisher: name: Imperial College London
Year: 2020

description: This thesis addresses the impact of nitrate supplementation in the form of beetroot juice as a potential therapeutic intervention to improve exercise capacity in people with chronic obstructive pulmonary disease (COPD). Dietary nitrate supplementation can enhance levels of plasma nitrite (NO2-), nitrate (NO3-) and nitric oxide (NO). Nitric oxide is a ubiquitous signalling molecule with impacts on systemic and pulmonary vasculature. It also effects skeletal muscle oxygen consumption. Within this thesis, I set out the background and evidence so far for NO3-supplementation in healthy individuals and those with COPD. To date studies have been small, with some conflicting findings. Specific potential responder phenotypes have not been selected for trials. I undertook a randomised controlled trial, comparing the effect of 140 mLs concentrated nitrate-rich beetroot juice (NR-BRJ) cut with organic lemon juice (2%) containing 0.8 g (12.9 mmol) NO3- (140 mL BEET-IT® SPORT Shot, James White Drinks, Ipswich, UK) against a placebo (PL-BRJ) beverage which was otherwise identical, except that the NO3- had been removed by passage through an ion exchange column. Participants with COPD consumed one or other beverage before each session of an eight-week pulmonary rehabilitation programme. Data were available for 122 study completers. The median (IQR) improvement in the ISWT distance following PR was statistically greater with NO3--rich NR-BRJ than PL-BRJ, increasing by 60 (10, 85)m compared to 30 (0, 70)m, an estimated treatment effect 30 m (95%CI: 10, 40); p = 0.027. In a single dose cross–over study in individuals with COPD who were established on long term oxygen therapy, endurance shuttle walk time was statistically significantly longer with NO3- supplementation compared to placebo 194.6 (147.5, 411.7)sec vs 159 (121.9, 298.5)sec, estimated treatment effect 62 sec (95%CI: 33, 106); p 0.0009. I also demonstrated that NO3- supplementation was associated with a fall in blood pressure and an improvement in endothelial function, assessed using flow-mediated dilatation. Dietary NO3- supplementation enhances exercise performance in hypoxic individuals with COPD and augments the effects of pulmonary rehabilitation. There may also be effects that are beneficial for cardiovascular co-morbidities which are extremely common in COPD.
Comment on "Doping Driven ($π,0$) Nesting and Magnetic Properties of Fe$_{1+x}$Te Superconductors" [Phys. Rev. Lett. 103, 067001 (2009)]
Creators: name: Singh, Prabhakar P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this Comment, using Korringa-Kohn-Rostoker coherent-potential approximation method in the atomic-sphere approximation (KKR-ASA CPA) to describe the effects of disorder due to excess Fe in FeTe alloys, we show that (i) the rigid-band approximation is inadequate to describe the effects of disorder and its application leads to an incorrect description of the underlying physics, (ii) the rigid-band energy shift of ~0.76 eV for going from FeTe to Fe_{1.068}Te (or Fe_{1.063}Te), as obtained by Han and Savrasov (Phys. Rev. Lett. 103, 067001(2009)), is inconsistent with our FP-LMTO as well as the KKR-ASA results, and thus the FS of Fe_{1.063}Te shown in Fig. 3(b) of their paper is not correct.
description: 1 page, 1 fig
YOSHLARNI TA'LIM TARBIYAGA BO'LGAN MUNOSABATLARINI  PSIXOLOGIK TOMONLAMA YO'NALGANLIGI
Creators: name: Qo'qon davlat pedagogi instituti Fakultetlararo  pedagogika va  psixologiya kafedra katta o'qituvchisi Meliquzieva Mavludaxon Texnologik ta'lim yo'nalishi talabasi  Maxmitalieva Zaxro 201 gurux
Publisher: name: Zenodo
Year: 2023

description: Ushbu makolada yoshlarning ta'lim tarbiyaga buysinishi pedagogik maxorat orqali yoshlik davridagi yigit va kizlarning karashlari. Ko'ngilchanlik, do'stlar ra`yiga qarshi bormaslik tufayli yoshlar xarakterida xislar, barqaror e`tiqod, ilmiy dunyoqarash, ichki kechinmalar, mustaqillik va tashabbuskorlik tuyg'ulari namayon bo'lishi to'g'risida ma'lumotlar berilgan.
Kalit so'zi: individual hayot, yoshlik davri inqirozi, ijtimoiy faollik, angi ijtimoiy   
mavqeiga erishishi va kasbiy o'zini o'zi anglash.
title: Μέθοδοι μηχανικής μάθησης στη ναυτιλία
title: Machine learning applications on maximum wave height for shipping and maritime
titleType: AlternativeTitle
Creators: name: Αμπατζή, Ζαχαρούλα
name: Ampatzi, Zacharoula
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: Μηχανική μάθηση
subject: Γραμμική παλινδρόμηση
subject: Λογιστική παλινδρόμηση
subject: Νευρωνικά δίκτυα
subject: Εφαρμογές προσομοίωσης θαλάσσιου κυματισμού

description: Στόχος της παρούσας διπλωματικής είναι η εισαγωγική παρουσίαση της επιστημονικής περιοχής της Μηχανικής Μάθησης και ενδεικτικών εφαρμογών της σε πραγματικές μελέτες που συνδέονται άμεσα ή έμμεσα με την Ναυτιλία. Ξεκινά με τον ορισμό και την ταξινόμηση της Μηχανικής Μάθησης, συνοδευόμενη από τις εξελίξεις της μέσα στο χρόνο. Στη συνέχεια παρέχει το υπολογιστικό υπόβαθρο και τις βασικές αρχές τεσσάρων αλγορίθμων Εποπτευόμενης Μηχανικής Μάθησης: Γραμμικής Παλινδρόμησης, Πολυωνυμικής Παλινδρόμησης, Λογιστικής Παλινδρόμησης και των Νευρωνικών Δικτύων. Τα βασικότερα πλεονεκτήματα και μειονεκτήματα παρουσιάζονται για όλες τις μεθόδους. Επεξηγείται επίσης η επιλογή της χρήσης του λογισμικού MATLAB, πριν προχωρήσουμε σε τρεις εφαρμογές που βασίζονται σε πραγματικά δεδομένα θαλάσσιου κυματισμού στο Αιγαίο και το Ιόνιο Πέλαγος. Στην κατεύθυνση αυτή χρησιμοποιούνται: ένα μοντέλο Γραμμικής Παλινδρόμησης για την εκτίμηση του μέγιστου ύψους κύματος, ένα μοντέλο Λογιστική Παλινδρόμησης για την υποστήριξη της απόφασης να εκδοθεί απαγόρευσης απόπλου από τις λιμενικές αρχές και ένα Νευρωνικό Δίκτυο για την προσομοίωση του ύψους κύματος, και της κατάστασης θάλασσας σύμφωνα με την κλίμακα Douglas. Η διπλωματική ολοκληρώνεται με τα συμπεράσματα που απορρέουν από τις εν λόγω εφαρμογές.
ФОРМИРОВАНИЕ ПОЗНАВАТЕЛЬНЫХ ИНТЕРЕСОВ МЛАДШИХ ШКОЛЬНИКОВ В ПРОЦЕССЕ ВЫПОЛНЕНИЯ ТВОРЧЕСКИХ ЗАДАНИЙ НА УРОКАХ РУССКОГО ЯЗЫКА
Creators: name: Хаджиева Сузанна Хусановна  студент 1 курса магистра по направлению теоретическая методология образования и обучения  Азиатского международного университета   города Бухары
Publisher: name: Zenodo
Year: 2023

description: Статья посвящена познавательному интересу младших школьников и его развитию в процессе обучения. Познавательный интерес следует признать как один из важнейших факторов образовательного процесса, влияние которого неоспоримо, как для создания яркой и радостной атмосферы обучения, так и для интенсивности познавательной деятельности младших школьников. При наличии познавательных интересов, учение становится близкой, жизненно важной деятельностью, в которой заинтересован сам школьник.
Ключевые слова: речь, важнейший фактор, познавательный процесс, обучение, интерес, система знаний.
Immunological determinants of lung protection and repair during viral infection
Creators: name: Major, Jack
Publisher: name: Imperial College London
Year: 2020

description: During infection with respiratory viruses, destruction of the lung epithelium is due to cytopathic viral effects in host cells, and damage generated by the ensuing inflammatory immune response. Host response pathways that protect or exacerbate lung tissue damage are not fully understood, particularly with regard to the impact on lung regeneration during recovery from disease. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced cytokines exerting pleiotropic antiviral, antiproliferative, and immunomodulatory effects in target cells. Here, we examine the effects of type I and III IFN on lung repair during recovery from influenza. We show that IFN signalling specifically induced in respiratory epithelial cells disrupts epithelial proliferation and differentiation during lung repair. IFN-λ drives these effects most potently, activating p53-dependent cell cycle arrest. Disruption of lung repair processes results in exacerbated lung tissue damage, compromised protective barrier function, and increased susceptibility to bacterial superinfections. Owing to the pathogenic potential of aberrant host immune responses, including IFNs, these pathways require tight regulation by host factors to limit tissue damage. This includes the environmental sensor aryl hydrocarbon receptor (AHR), which has been shown to enhance barrier immunity, promote disease tolerance, and suppress IFN production during viral infection. Using genetic models to increase the availability of natural AHR ligands, we show that the AHR induces signals in lung barrier tissues to reduce pulmonary damage and dampen inflammation. Tissue-protective pathways induced by the AHR appear to occur independently from AHR-dependent regulation of IFN production. Taken together, our data highlights the importance of timing and regulation in generating protective antiviral immunity and lung barrier protection, in order to prevent the development of pathogenic, tissue-damaging responses.
On detecting the large separation in the autocorrelation of stellar oscillation times series
Creators: name: Mosser, B.
name: Appourchaux, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The observations carried out by the space missions CoRoT and Kepler provide a large set of asteroseismic data. Their analysis requires an efficient procedure first to determine if the star is reliably showing solar-like oscillations, second to measure the so-called large separation, third to estimate the asteroseismic information that can be retrieved from the Fourier spectrum. We develop in this paper a procedure, based on the autocorrelation of the seismic Fourier spectrum. We have searched for criteria able to predict the output that one can expect from the analysis by autocorrelation of a seismic time series. First, the autocorrelation is properly scaled for taking into account the contribution of white noise. Then, we use the null hypothesis H0 test to assess the reliability of the autocorrelation analysis. Calculations based on solar and CoRoT times series are performed in order to quantify the performance as a function of the amplitude of the autocorrelation signal. We propose an automated determination of the large separation, whose reliability is quantified by the H0 test. We apply this method to analyze a large set of red giants observed by CoRoT. We estimate the expected performance for photometric time series of the Kepler mission. Finally, we demonstrate that the method makes it possible to distinguish l=0 from l=1 modes. The envelope autocorrelation function has proven to be very powerful for the determination of the large separation in noisy asteroseismic data, since it enables us to quantify the precision of the performance of different measurements: mean large separation, variation of the large separation with frequency, small separation and degree identification.
description: A&A, in press
Neural feedback mechanisms for speech-in-noise listening
Creators: name: Saiz Alia, Marina
Publisher: name: Imperial College London
Year: 2020

description: The human auditory system is exceptional at comprehending an individual speaker even in complex acoustic environments. The neural mechanisms involved in such speech-in-noise listening remain, however, poorly explored. This is partly due to the complexity of natural speech as well as of many real-world background sounds. However, methods from statistical learning have recently been employed to measure neural responses to real-world stimuli such as speech. Such studies have, for instance, found a role of subcortical structures in selective attention to speech. Nevertheless, it remains unclear whether these neural processes may inform on “hidden” forms of hearing impairment, such as cochlear synaptopathy, that may cause difficulty with speech-in-noise listening. In this thesis we investigate the subcortical processing of naturalistic speech and its relation to speech-in-noise performance, using non-invasive clinically applicable measurements as well as computational modelling. We find that the speech-evoked activities in the auditory brainstem (speech-ABR) and in the cochlea (speech-OAE) are larger when a speech signal is attended than when it is ignored. The variability in the modulation of the brainstem response to speech relates to the ability of the subjects to understand speech in noise but does not correlate with proposed measures for cochlear synaptopathy. The computational model results confirm that the speech-ABR is dominated by neural responses in the inferior colliculus and that the response is shaped by nonlinearities and interaction between different harmonics. Regarding the role of the inner ear, or cochlea, we develop a method to record otoacoustic emissions related to speech (speech-OAEs). We show that these speech-OAEs are modulated by selective attention to speech, and that this modulation in turn correlates with a subject’s ability to understand speech in noise. Our work shows that neural processing in subcortical structures contributes to speech-in-noise listening and can inform on speech-in-noise deficits.