cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 3D Point Cloud Shapes Latent Representation Learning and Applications
Creators: name: Li, Shidi
Publisher: name: The Australian National University
Year: 2025

description: Due to the rapid advancement of machine learning, 3D object modeling has become a central focus in computer vision. A significant challenge lies in acquiring a latent representation for diverse 3D objects that is information-rich, efficient, and ubiquitous. This thesis tackles the above challenge from three fronts -- 1) how to learn information-rich disentangled latent representations in an unsupervised manner? 2) how to organize the learned disentangled latent representation efficiently in an unsupervised manner? 3) how to develop an ubiquitous general-purpose latent representation that can be readily applied to various downstream tasks with minimal additional training. This thesis first proposes a novel framework, namely \editvae, for unsupervised learning of disentangled latent representations of 3D objects. \editvae\ enables direct generation of individual object parts by training the model with whole object data. In particular, the learnt latent representation can be decomposed into a disentangled representation for each part of the shape. These parts are further decomposed into a shape primitive and a point cloud representation, along with a standardising transformation to a canonical coordinate system. Importantly, the dependencies between these transformations preserve spatial relationships between parts, facilitating meaningful parts-aware point cloud generation and shape editing. Further, beyond the learned information-rich latent representation, this thesis proposes \spavae\ with an unsupervised similar parts assignment module to organize the explicit disentangled representation. To be specific, \spavae\ infers a set of latent canonical candidate shapes for an object, along with a set of rigid body transformations for each such candidate shape to one or more locations within the assembled object. In this way, noisy samples on the surface of, say, each leg of a 3D point cloud table, are effectively organized and combined to estimate a single leg prototype. When parts-based self-similarity exists in the raw data, sharing data among parts in this way confers numerous advantages: modeling accuracy, appropriately self-similar generative outputs, precise in-filling of occlusions, and model parsimony. Finally, this thesis proposes a unified latent representation that facilitates its application to diverse downstream tasks. This thesis propose a novel sparse transformer, \textit{sampled transformer}, with $O(n)$ complexity that can efficiently process point set elements with little additional inductive bias. This transformer is then integrated into a Masked Auto-Encoder (MAE) pre-training framework for learning an ubiquitous latent representation. The success of this representation in fine-tuning tasks like classification, transfer learning, few-shot learning, and generation demonstrates its effectiveness in capturing rich object information.
Floating norms for individualising the ANB angle and the WITS appraisal in orthodontic cephalometric analysis based on guiding variables
Creators: name: Paddenberg, Eva
name: Proff, Peter
name: Kirschneck, Christian
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Skeletal sagittal class, Lateral cephalograms, Angle class I malocclusion, Orthodontic treatment, Orthodontic diagnostics
subject: 610 Medizin

description: Purpose
The sagittal skeletal relationship of maxilla and mandible (skeletal class) can generally be determined via lateral cephalograms (ANB angle or Wits appraisal) by comparing measurements to empirical norms based on the respective population mean. However, values differing from these empirical norms also enable a therapeutically desired, normal class I occlusion depending on individual craniofacial pattern, thus requiring floating norms based on guiding variables. As available regression equations consider only few predictor variables and are not up-to-date regarding a contemporary patient collective, the aim of this study was to establish improved and extended regression equations for individualising the ANB angle and Wits appraisal.
Methods
This retrospective, cross-sectional multicentre study was based on 71 Caucasian male and female subjects of any age with normal dental occlusion. We cephalometrically analysed digitised pretreatment lateral radiographs and performed multiple linear regression analyses to identify suitable skeletal predictor variables for individualising the ANB angle and Wits appraisal.
Results
Inter- and intrarater reliability tests showed mostly perfect measurement concordance. Both original regression equations by Panagiotidis/Witt and Järvinen could be updated for a contemporary population with new regression coefficients. The equation for individualising the ANB could be further optimised in its prediction reliability by adding the skeletal predictor variables NL-NSL, NSBa, facial axis (Ricketts) and index (Hasund), whereas the recalculated Wits equation could not be further improved by additional guiding variables.
Conclusions
The improved regression formulae for individualising the ANB angle and Wits appraisal should help to improve the assessment of sagittal skeletal class in clinical orthodontic practice.
Examining the relationship between per-and polyfluoroalkyl substances and breast, colorectal, prostate, and ovarian cancers: a meta-analysis
Creators: name: Sezavar, Ahmad Habibian
name: Rastegar-Pouyani, Nima
name: Kakavandi, Nader Rahimi
name: Fakhari, Fatemeh
name: Jafarzadeh, Emad
name: Aliebrahimi, Shima
name: Ostad, Seyed Nasser
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used widely in industrial and commercial applications. Concerns exist about their potential link to cancer risk as possible endocrine-disrupting chemicals. We conducted a meta-analysis to evaluate the dose-response relationship between PFAS, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorohexanesulfonic acid (PFHxS) exposure and risk of breast, prostate, colorectal, and ovarian cancers. We systematically searched major databases through May 2022 and identified 13 observational studies for inclusion. Using random-effects models, we calculated summary odds ratios (ORs) and 95% confidence intervals (CIs) comparing the highest versus lowest PFAS exposure categories. Additionally, we analyzed the dose-response correlation between PFAS and cancer risk in a subset of studies. The study revealed no substantial correlation between exposure to PFASs and the incidence of breast cancer (BC) (ORPFOS = 1.15, 95% CI = 0.91–1.46, ORPFOA = 1.01, 95% CI = 0.68–1.50, ORPFNA = 0.88, 95% CI = 0.64–1.21, ORPFHxS = 1.22, 95% CI = 0.40–3.77, and ORPFDA = 1.29, 95% CI = 0.41–4.10), ovarian cancer (ORPFOA = 1.43, 95% CI = 0.84–2.42), prostate cancer (ORPFOA = 1.05, 95% CI = 0.88–1.26), and colorectal cancer (ORPFOA = 0.77, 95% CI = 0.53–1.12) in the highest versus lowest exposure analysis. However, dose-response analysis showed that for every 1 ng/ml increase in PFNA and 2 ng/ml increase in PFOA, the relative risk for BC decreased significantly (RR 0.67, 95% CI 0.45–0.99 and RR 0.94, 95% CI 0.89–0.98, respectively). Non-linear dose-response analysis found no significant changes in BC risk with increasing PFAS levels. In conclusion, while the highest versus lowest analysis does not support associations between PFAS exposure and the risk of these cancers, linear dose-response analysis suggests potential inverse relationships between PFNA/PFOA levels and BC risk. Further research is warranted on these potential protective effects.
Additional file 5: Figure S2. of Measure transcript integrity using RNA-seq data
Creators: name: Liguo Wang
name: Jinfu Nie
name: Sicotte, Hugues
name: Li, Ying
name: Eckel-Passow, Jeanette
name: Surendra Dasari
name: Vedell, Peter
name: Poulami Barman
name: Liewei Wang
name: Weinshiboum, Richard
name: Jen, Jin
name: Haojie Huang
name: Kohli, Manish
name: Kocher, Jean-Pierre
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: RIN (RNA integrity number) score distribution for 120 metastatic castration resistant prostate cancer (mCRPC) samples. (PDF 9 kb)
Additional file 1: Table S1. of Saliva DNA quality and genotyping efficiency in a predominantly elderly population
Creators: name: Harini Gudiseva
name: Hansen, Mark
name: Gutierrez, Linda
name: Collins, David
name: He, Jie
name: Verkuil, Lana
name: Danford, Ian
name: Sagaser, Anna
name: Bowman, Anita
name: Salowe, Rebecca
name: Prithvi Sankar
name: Eydie Miller-Ellis
name: Lehman, Amanda
name: O’Brien, Joan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Subject gender, age, DNA characteristics and genotyping results corresponding to the samples used for genotyping. (“B” sample IDs indicate DNA from blood and “S” sample IDs are DNA from saliva). (DOCX 31 kb)
Additional file 20: Figure S14. of Measure transcript integrity using RNA-seq data
Creators: name: Liguo Wang
name: Jinfu Nie
name: Sicotte, Hugues
name: Li, Ying
name: Eckel-Passow, Jeanette
name: Surendra Dasari
name: Vedell, Peter
name: Poulami Barman
name: Liewei Wang
name: Weinshiboum, Richard
name: Jen, Jin
name: Haojie Huang
name: Kohli, Manish
name: Kocher, Jean-Pierre
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Venn diagram showing the overlapping between 665 DEGs (before TIN correction) and 289 DEGs (after TIN correction). DEG, differentially expressed gene. (PDF 101 kb)
Additional file 1: of Perceptions of the general public and physicians regarding open disclosure in Korea: a qualitative study
Creators: name: Minsu Ock
name: Kim, Hyun
name: Min-Woo Jo
name: Lee, Sang-Il
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Guidelines for the in-depth interviews and focus group discussions including full descriptions of hypothetical cases. (DOCX 20 kb)
Zahn- und Kieferfehlstellungen – gesundheitliche Relevanz und Behandlung
Creators: name: Ruf, Sabine
name: Proff, Peter
name: Lisson, Jörg
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ORAL-HEALTH; GENERAL HEALTH; ORTHODONTICS; PREVALENCE; DISORDERS; CHILDREN; TRAITS; IMPACT; Malocclusion; Orthodontics; Oral health; General health; Quality of life
subject: 610 Medizin

description: Malocclusions are among the most common human diseases impairing oral health. The present paper gives an overview on their etiology, prevalence, and consequences. It further presents the corrective and preventive potential of orthodontic treatment and gives information on the treatment-associated legal framework in Germany. The use and quality of the orthodontic health service will be described in the international context. The etiology of malocclusions has genetic, epigenetic, functional, and environmental components, which can seldomly be differentiated on the individual level. Previous small, cross-sectional studies show that up to 80% of children in Germany are affected. Eating, drinking, chewing, speaking, and breathing may be impaired and the predisposition for periodontal disease and overuse injuries of the temporomandibular joint and the masticatory musculature increase. A proclination of the upper incisors increases the risk for dental trauma. Furthermore, malocclusions may have negative psychosocial effects and impair quality of life. In cooperation with other dental and/or medical disciplines, orthodontics make positive preventive and curative contributions to oral health, general health, and quality of life. Against this background, orthodontics has a substantial potential for the enhancement of dental prevention in healthcare. This is especially true as the German social health insurance (GKV) allows for a widespread orthodontic treatment coverage of the population at an internationally accepted, high-quality level. To further improve prevention, the implementation of a systematic orthodontic screening at the age of 7-8 years in the form of a systematic preventive measure is recommended.
Long-term improvement of quality of life in patients with breast cancer: supporting patient-physician communication by an electronic tool for inpatient and outpatient care
Creators: name: Lindberg-Scharf, Patricia
name: Steinger, Brunhilde
name: Koller, Michael
name: Hofstädter, Andrea
name: Ortmann, Olaf
name: Kurz, Jan
name: Sasse, Jonathan
name: Klinkhammer-Schalke, Monika
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: REPORTED OUTCOME MEASURES; EUROPEAN-ORGANIZATION; RANDOMIZED-TRIAL; THERAPY; HEALTH; EQUIVALENCE; INSTRUMENT; DIAGNOSIS; WOMEN; Quality of life; Patient-reported outcomes; Breast cancer; Electronic assessment; Patient-physician communication; Complex intervention
subject: 610 Medizin

description: Purpose The effectiveness of a pathway with quality of life (QoL) diagnosis and therapy has been already demonstrated in an earlier randomized trial (RCT) in patients with breast cancer. We refined the pathway by developing and evaluating an electronic tool for QoL assessment in routine inpatient and outpatient care. Methods In a single-arm study, patients with breast cancer with surgical treatment in two German hospitals were enrolled. QoL (EORTC QLQ-C30, QLQ-BR23) was measured with an electronic tool after surgery and during aftercare in outpatient medical practices (3, 6, 9, 12, 18, and 24 months) so that results (QoL-profile) were available immediately. Feedback by patients and physicians was analyzed to evaluate feasibility and impact on patient-physician communication. Results Between May 2016 and July 2018, 56 patients were enrolled. Physicians evaluated the QoL pathway as feasible. Patients whose physician regularly discussed QoL-profiles with them reported significantly more often that their specific needs were cared for (p < .001) and that their physician had found the right treatment strategy for these needs (p < .001) compared with patients whose doctor never/rarely discussed QoL-profiles. The latter significantly more often had no benefit from QoL assessments (p < .001). Conclusion The QoL pathway with electronic QoL assessments is feasible for inpatient and outpatient care. QoL results should be discussed directly with the patient.
Additional file 13: Figure S10. of Measure transcript integrity using RNA-seq data
Creators: name: Liguo Wang
name: Jinfu Nie
name: Sicotte, Hugues
name: Li, Ying
name: Eckel-Passow, Jeanette
name: Surendra Dasari
name: Vedell, Peter
name: Poulami Barman
name: Liewei Wang
name: Weinshiboum, Richard
name: Jen, Jin
name: Haojie Huang
name: Kohli, Manish
name: Kocher, Jean-Pierre
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: Relationship between GC content (GC-ratio) and TIN score for 12 Glioblastome cell line samples. (a)-(c) three samples with RIN value of 10; (d)-(e), two samples with RIN value of 8; (f)-(h) three samples with RIN value of 6; (i)-(k) three samples with RIN value of 4; (l) one sample with RIN value of 2. r, Pearson correlation coefficient. r, Pearson correlation coefficient. Linear regression lines fitted to data are indicated as black dashed lines. (PDF 6617 kb)
Психологическая травма: ретроспективный анализ проблемы
Creators: name: Радченко Аксиния Михайловна
name: Садовникова Надежда Олеговна
Publisher: name: Концепт
Year: 2024
Subjects: психологическая травма

description: Актуальность исследования обусловлена тем, что человек на протяжении всей жизни, с самого рождения, находится в уязвимом положении от воздействия как внутренних, так и внешних факторов. Особую важность изучению феномена психологической травмы на современном этапе придает высокий темп общественного развития и смены окружающих условий. Основная цель исследования заключается в проведении ретроспективного анализа взглядов разных исследователей на проблему психологической травмы. Результатом исследования выступает представленный анализ концепций и практических моделей терапии по вопросу психологической травмы.
Additional file 16: Figure S12. of Measure transcript integrity using RNA-seq data
Creators: name: Liguo Wang
name: Jinfu Nie
name: Sicotte, Hugues
name: Li, Ying
name: Eckel-Passow, Jeanette
name: Surendra Dasari
name: Vedell, Peter
name: Poulami Barman
name: Liewei Wang
name: Weinshiboum, Richard
name: Jen, Jin
name: Haojie Huang
name: Kohli, Manish
name: Kocher, Jean-Pierre
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Dependency between FPKM (y-axis) and TIN scores (x-axis) for all 6 Glioblastoma (GBM) samples. (a)-(c) 3 GBM samples with RIN value of 10. (d)-(f) 3 GBM samples with RIN value of 4. FPKM, Fragment Per Kilobase exon per Million mapped reads. r, Pearson correlation coefficient. Linear regression lines fitted to data are indicated as red dashed lines. (PDF 3998 kb)
KICHIK BIZNES VA TADBIRKORLIKNING MOLIYAVIY FAOLIYATINI IFODALOVCHI KO'RSATKICHLAR
Creators: name: Amangeldiyeva, Raxila
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada kichik biznes va tadbirkorlikning moliyaviy faoliyatini ifodalovchi asosiy ko‘rsatkichlar tahlil qilinadi. Jumladan, foyda, sotishdan tushgan sof tushum va tasodifiy daromadlarning mohiyati, ularni hisoblash usullari va ahamiyati batafsil yoritiladi. Moliyaviy ko‘rsatkichlarni tahlil qilishning kichik biznes faoliyatini samarali boshqarish va rivojlantirishdagi o‘rni o‘rganiladi. Mazkur ko‘rsatkichlarni to‘g‘ri boshqarish orqali korxonalar o‘z moliyaviy barqarorligini ta’minlashi va kelajakdagi rivojlanish strategiyalarini samarali rejalashtirishi mumkinligi ta’kidlanadi.
Scavengers and biotechnology: a brief Q&A for the Spanish newspaper El País
Creators: name: Cushnie, T. P. Tim
name: Luang-In, Vijitra
name: Sexton, Darren W.
Publisher: name: Zenodo
Year: 2024
Subjects: scavenger
necrophage
necrophagous
immunity
biotechnology
antibacterial
drug discovery
biocides
biomaterials
probiotics
bioprospecting
product development
commercialization

description: Scavengers are animals that feed on carrion, the decaying flesh or tissue of dead animals. Our research group recently studied the diets, antibacterial defences and biotechnological potential of over 600 scavenger species. In this interview with journalist Javier Yanes, he asks us about the advantages of this area of antibacterial research compared to other more traditional lines of investigation. We also discuss some of the commercial considerations in bringing antibacterial products to market.
Состояние гидроэнергетики Германии
Creators: name: Таскин Фёдор Александрович
Publisher: name: Концепт
Year: 2024
Subjects: Германия
возобновляемые источники энергии
гидроэнергетика
ГЭС
мощность
объем выработки
потребители энергии

description: Гидроэнергетика является наиболее развитой областью энергетики на возобновляемых ресурсах в Германии. Немецкий опыт функционирования гидроэлектростанций, использования новых технологий и нормирования процессов может быть полезен многим странам мира. Целью исследования является оценка состояния гидроэнергетики Германии и перспективы ее развития. В ходе работы изучена нормативная база по гидроэнергетике, проведен анализ ряда показателей работы гидроэлектростанций, рассмотрены перспективы совершенствования гидроэнергетических объектов. Сформулирован вывод о развитии гидроэнергетики Германии за счет модернизации старых, строительства малых и крупных по мощности, шахтных гидроэлектростанций.
THE VALUE OF OPTIMAL LOCATION OF AGGLOMERATION IN THE DEVELOPMENT OF TOURISM IN THE REGION
Creators: name: Toshev, Nurbek
Publisher: name: Zenodo
Year: 2024

description: This article examines the relevance of optimal placement of agglomeration in the development of tourism in the region. Effective management of tourism potential, optimization of infrastructure, rational use of resources and strengthening of tourism interregional cooperation will be covered. As a result of the study, practical recommendations were developed on the geographical location of the agglomeration and its impact on economic efficiency.
Additional file 3: of Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer
Creators: name: Kumar, Manish
name: Matta, Ajay
name: Masui, Olena
name: Srivastava, Gunjan
name: Kaur, Jatinder
name: Thakar, Alok
name: Nootan Shukla
name: Ajoy RoyChoudhury
name: Meherchand Sharma
name: Walfish, Paul
name: K. Michael Siu
name: Chauhan, Shyam
name: Ranju Ralhan
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry

description: Table S1. List of key proteins identified as binding partners of hnRNPD in OSCC cells (SCC-4 / MDA1986) using IP-LC-MS/MS.
ANÁLISE DO CUSTO DOS COMPONENTES ALIMENTÍCIOS DA CESTA BÁSICA COM SUAS QUANTIDADES E PESOS NA MICRORREGIÃO DE AVARÉ
Creators: name: JUNIOR, ISRAEL DA SILVA
Publisher: name: Zenodo
Year: 2012

description: De acordo com o IPEA (2004), o estudo da Cesta Básica tem sua origem na década de 30, dentro do contexto da política trabalhista de Getulio Vargas, sendo desde então referencial no levantamento de preços ao consumidor e uma preocupação dos especialistas da área econômica. Isto porque a correlação do custo da Cesta Básica com o salário mínimo vigente no pais é uma espécie de medidor da necessidade da construção e melhoria de políticas mais justas. Desta forma, percebendo a importância e se realizar uma pesquisa e criar um banco de dados referente a esse indicador econômico na Microrregião de Avaré, foi criado em julho/2011 no Curso de Ciências Contábeis e Administrativas de Avaré o Laboratório Socioeconômico juntamente a pesquisa intitulada “Analise da Evolução dos Custos da Cesta Básica de Consumo Popular” com o objetivo de criar um banco de dados do custo da cesta básica na Microrregião de Avaré.
MOESM1 of Oral artemisinin monotherapy removal from the private sector in Eastern Myanmar between 2012 and 2014
Creators: name: Hnin Khin
name: Aung, Tin
name: Aung Thi
name: White, Chris
Publisher: name: Figshare
Year: 2016
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Outlet survey Myanmar questionnaire, 2014. This file includes the full questionnaire administered during Myanmarâ  s 2014 outlet survey.
Состояние и перспективы развития гостиничного бизнеса в Алтайском крае
Creators: name: Мельникова Ольга Владимировна
name: Комарова Дарья Владимировна
Publisher: name: Концепт
Year: 2024
Subjects: гостиничный бизнес
анализ
туризм
средства размещения
вместимость
туристический поток
ценовая политика
типы отелей
тенденции
проблемы развития

description: Гостиничный бизнес – это самая крупная составляющая туристической отрасли. Следовательно, от развития гостиничного бизнеса зависит и развитие всей туриндустрии. Целью работы является оценка состояния и перспектив развития гостиничного бизнеса на региональном уровне. В статье представлены результаты исследования основных современных тенденций развития гостиничного бизнеса в Алтайском крае. Рассмотрены проблемы развития гостиничного бизнеса, такие как физическое и моральное «старение» материального фонда, недостаток квалифицированных кадров, рост конкуренции.
ПРОБАЦИЯ БОШҚАРМАСИНИНГ ФУҚАРОЛИК ЖАМИЯТИ ИНСТИТУТЛАРИ БИЛАН ҲАМКОРЛИГИНИНГ ҲУҚУҚИЙ АСОСЛАРИ
Creators: name: Аманов, Аброржон
Publisher: name: Zenodo
Year: 2024

description: Мақолада Пробация бошқармасининг фуқаролик жамияти институтлари билан ҳамкорлигининг ҳуқуқий асослари хусусида фикр юритилиб, мазкур фаолиятни янада самарали ташкил этишга оид таклиф ҳамда тавсиялар билдирилган.
Additional file 2: of Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy
Creators: name: Yongxian Hu
name: Sun, Jie
name: Wu, Zhao
name: Yu, Jian
name: Cui, Qu
name: Chengfei Pu
name: Liang, Bin
name: Luo, Yi
name: Jimin Shi
name: Aiyun Jin
name: Xiao, Lei
name: Huang, He
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Preparation of chimeric antigen receptor-modified (CAR) T cells targeting CD19 (CART19). (DOCX 16.7 KB)
Epistatic interactions of genetic loci associated with age-related macular degeneration
Creators: name: Weber, Bernhard H. F.
name: Kiel, Christina
name: Nebauer, Christoph A.
name: Strunz, Tobias
name: Stelzl, Simon
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: GENOME-WIDE ASSOCIATION; METABOLISM; EXPRESSION; MECHANISMS; EQTL
subject: 610 Medizin

description: The currently largest genome-wide association study (GWAS) for age-related macular degeneration (AMD) defines disease association with genome-wide significance for 52 independent common and rare genetic variants across 34 chromosomal loci. Overall, these loci contain over 7200 variants and are enriched for genes with functions indicating several shared cellular processes. Still, the precise mechanisms leading to AMD pathology are largely unknown. Here, we exploit the phenomenon of epistatic interaction to identify seemingly independent AMD-associated variants that reveal joint effects on gene expression. We focus on genetic variants associated with lipid metabolism, organization of extracellular structures, and innate immunity, specifically the complement cascade. Multiple combinations of independent variants were used to generate genetic risk scores allowing gene expression in liver to be compared between low and high-risk AMD. We identified genetic variant combinations correlating significantly with expression of 26 genes, of which 19 have not been associated with AMD before. This study defines novel targets and allows prioritizing further functional work into AMD pathobiology.
Additional file 1: of Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy
Creators: name: Yongxian Hu
name: Sun, Jie
name: Wu, Zhao
name: Yu, Jian
name: Cui, Qu
name: Chengfei Pu
name: Liang, Bin
name: Luo, Yi
name: Jimin Shi
name: Aiyun Jin
name: Xiao, Lei
name: Huang, He
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Detailed patient information and procedures of diagnosis and treatment. (DOCX 17.2 KB)
The Legacy of (Post-) 9/11 (Fiction): Architectural Ekphrasis and the Shapes of Memory in Amy Waldman’s "The Submission"
Creators: name: Tseti, Angeliki
Publisher: name: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
Year: 2024
Subjects: architecture; ekphrasis; counter-monument; post-9/11 fiction; memory

description: This article reads Amy Waldman’s The Submission focusing on the ways the writer draws directly on architecture’s impact on the city’s daily life to investigate the forms and shapes of memory as these are reflected in a type of monumental architecture that eschews the competitive flow of memory traversing the nation, thus constituting a site of convergence. Placing special emphasis on the work’s particular relevance in the 2020s, The Submission is highlighted for its prescient qualities, as a novel that does not only mirror the division of a wounded nation in the aftermath of the attacks, but also addresses America’s state of crisis in the present. More importantly, this article argues that the writer’s choice to depict the memorial in ekphrasis insightfully points to the workings of memory as a starting point for America to retrieve its unity, and thus multifariously foresees the legacy of (Post-)9/11 (fiction)’s preoccupations in the immediate future.
description: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media, No 8 (2024): Mobile Locative Media and Hybrid Narrative Spaces & Other Essays
Additional file 4: Table S2. of
                     De novo transcriptome sequencing and gene expression analysis reveal potential mechanisms of seed abortion in dove tree (Davidia involucrata Baill.)
Creators: name: Li, Meng
name: Xujie Dong
name: Jiqing Peng
name: Xu, Wen
name: Ren, Rui
name: Liu, Jane
name: Fuxiang Cao
name: Zhiming Liu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Correlation coefficient between RPKM of unigenes of samples. (PDF 93 kb)
Additional file 6: Figure S1. of
                     De novo transcriptome sequencing and gene expression analysis reveal potential mechanisms of seed abortion in dove tree (Davidia involucrata Baill.)
Creators: name: Li, Meng
name: Xujie Dong
name: Jiqing Peng
name: Xu, Wen
name: Ren, Rui
name: Liu, Jane
name: Fuxiang Cao
name: Zhiming Liu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Gene expression in normal and aborted seeds detected by qPCR. (PDF 313 kb)
MOESM1 of Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos
Creators: name: Zhongzhen Liu
name: Cheng, Tina
name: Zhaoying Shi
name: Ziran Liu
name: Lei, Yong
name: Chengdong Wang
name: Weili Shi
name: Xiongfeng Chen
name: Xufeng Qi
name: Dongqing Cai
name: Feng, Bo
name: Deng, Yi
name: Yonglong Chen
name: Zhao, Hui
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 1. Supplementary figures and legends.
Additional file 3: Table S1. of
                     De novo transcriptome sequencing and gene expression analysis reveal potential mechanisms of seed abortion in dove tree (Davidia involucrata Baill.)
Creators: name: Li, Meng
name: Xujie Dong
name: Jiqing Peng
name: Xu, Wen
name: Ren, Rui
name: Liu, Jane
name: Fuxiang Cao
name: Zhiming Liu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Summary for the annotation of unigenes against database of other species. (PDF 9 kb)
Julia M. Hildebrand, Aerial Play: Drone Medium, Mobility, Communication, and Culture. Palgrave Macmillan, 2021, pp. 207.
Creators: name: Mantzaris, Thomas
Publisher: name: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
Year: 2024

description: Book Review
description: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media, No 8 (2024): Mobile Locative Media and Hybrid Narrative Spaces & Other Essays
Additional file 7: Table S3. of
                     De novo transcriptome sequencing and gene expression analysis reveal potential mechanisms of seed abortion in dove tree (Davidia involucrata Baill.)
Creators: name: Li, Meng
name: Xujie Dong
name: Jiqing Peng
name: Xu, Wen
name: Ren, Rui
name: Liu, Jane
name: Fuxiang Cao
name: Zhiming Liu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Primer sequences used in qPCR. (PDF 34 kb)
Soundscape Podcast: Reimagining the Museum Experience at MOMus Contemporary
Creators: name: Ignatiadou, Elena
Publisher: name: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
Year: 2024
Subjects: soundscape; museum; immersive experience; podcast; podplays

description: This research paper aims to create a podcast consisting of soundscapes as an alternative way to live the museum experience. The particular podcast is based on the museum of contemporary art of MOMus (Metropolitan Organization of Museums of Visual Arts of Thessaloniki). In more detail, the paper investigates soundscapes as a means of modernizing the museum’s guided tour, so that guests can have a more augmented and immersive experience through the usage of current media trends and digital technologies. In combination with some narrative elements, soundscapes guide guests through the museum’s permanent exhibition, provide basic information about the selected showpieces, and transfuse to the visitors the feelings behind them. In addition to the production of soundscapes, the paper reviews the theory behind podcasts and soundscapes, and investigates similar projects.
description: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media, No 8 (2024): Mobile Locative Media and Hybrid Narrative Spaces & Other Essays
"Wanderers": A Mobile Locative Sonification of Planetary Movement
Creators: name: Azaretto, Roberto
name: Rueb, Teri
Publisher: name: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
Year: 2024
Subjects: sonification; mobile locative media; education; sound; art; embodiment; phenomenology; posthumanism

description: Wanderers is a responsive experience delivered via a mobile app that responds to the visitor’s movement as sensed by GPS. The app functions as a complement to the Colorado Scale Model Solar System represented by plaques that extend from the Fiske Planetarium to Colorado Boulevard on the CU Boulder campus. Wanderers allows visitors to explore the sonic, temporal, and spatial dynamics of our Solar System as a soundscape extending in all directions from the Sun, located in front of the Fiske Planetarium. The mobile listener can explore a sonification in which the relative mass and orbital period of the planets are expressed, with each celestial body having its own “sound print.” As the listener wanders, and the sonified celestial bodies move at their relative orbital speeds, the participant hears a dynamic soundscape where the volume and direction of the sounds changes depending on the participant’s position and perspective. This article elaborates on experiential ways of knowing facilitated by the app, highlighting the translation of astronomical scale, and spatial and temporal processes to human scale perception via locative media. Posthumanism and philosophy of embodiment provide theoretical foundations.
description: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media, No 8 (2024): Mobile Locative Media and Hybrid Narrative Spaces & Other Essays
MOESM2 of Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells
Creators: name: Shingu, Takashi
name: Holmes, Lindsay
name: Henry, Verlene
name: Qianghu Wang
name: Khatri Latha
name: Gururaj, Anupama
name: Gibson, Laura
name: Doucette, Tiffany
name: Lang, Frederick
name: Rao, Ganesh
name: Yuan, Liang
name: Sulman, Erik
name: Farrell, Nicholas
name: Priebe, Waldemar
name: Hess, Kenneth
name: Yaoqi Wang
name: Hu, Jian
name: BĂśgler, Oliver
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Supplementary figure.
Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients
Creators: name: Schramm, René
name: Costard-Jäckle, Angelika
name: Rivinius, Rasmus
name: Fischer, Bastian
name: Müller, Benjamin
name: Boeken, Udo
name: Haneya, Assad
name: Provaznik, Zdenek
name: Knabbe, Cornelius
name: Gummert, Jan
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ;Covid-19 infection; BioNTech; Pfizer (BNT162b2) vaccine; Immunocompromised patients; Transplant recipients; Immunogenicity
subject: 610 Medizin

description: Aims 
Immunocompromised patients have been excluded from studies of SARS-CoV-2 messenger RNA vaccines. The immune response to vaccines against other infectious agents has been shown to be blunted in such patients. We aimed to analyse the humoral and cellular response to prime-boost vaccination with the BNT162b2 vaccine (Pfizer-BioNTech) in cardiothoracic transplant recipients. 

Methods and results 
A total of 50 transplant patients [1-3 years post heart (42), lung (7), or heart-lung (1) transplant, mean age 55 +/- 10 years] and a control group of 50 healthy staff members were included. Blood samples were analysed 21 days after the prime and the boosting dose, respectively, to quantify anti-SARS-CoV-2 spike protein (S) immunoglobulin titres (tested by Abbott, Euroimmun and RocheElecsys Immunoassays, each) and the functional inhibitory capacity of neutralizing antibodies (Genscript). To test for a specific T-cell response, heparinized whole blood was stimulated with SARS-CoV-2 specific peptides, covering domains of the viral spike, nucleocapsid and membrane protein, and the interferon-gamma release was measured (QuantiFERON Monitor ELISA, Qiagen). The vast majority of transplant patients (90%) showed neither a detectable humoral nor a T-cell response three weeks after the completed two-dose BNT162b2 vaccination; these results are in sharp contrast to the robust immunogenicity seen in the control group: 98% exhibited seroconversion after the prime dose already, with a further significant increase of IgG titres after the booster dose (average > tenfold increase), a more than 90% inhibition capability of neutralizing antibodies as well as evidence of a T-cell responsiveness. 

Conclusions 
The findings of poor immune responses to a two-dose BNT162b2 vaccination in cardiothoracic transplant patients have a significant impact for organ transplant recipients specifically and possibly for immunocompromised patients in general. It urges for a review of future vaccine strategies in these patients.
Making Sense of Audiowalks: Methodological Considerations for the Study of Locative Media
Creators: name: Stougaard Pedersen, Birgitte
name: Engberg, Maria
Publisher: name: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
Year: 2024
Subjects: locative media; audiowalks; sonic ethnography

description: This article discusses audiowalks as mobile locative media and raises issues around how to analyze such hybrid and situated aesthetic and narrative experiences. We employ sensory ethnographies coupled with post-phenomenological concepts to present a mode of analysis that captures the relationality between the technological and embodied aspects of the experiences. Audiowalks and similar hybrid experiences are created and experienced through several media formats (text, image, sound) and exist in between and across several aesthetic traditions and genres (literature, art, music). The case that we analyze in the article uses mobile media to distribute locative digital experiences that are intimately tied to geographical places: Ellen Reid’s SOUNDWALK is a GPS-enabled work of public art that uses music to illuminate the natural environment (and can be found in several cities currently). We suggest that a situated awareness is needed to critically analyze works such as this, and that sensory ethnographic approaches in combination with multistability created by technology can be adapted to suit such an analysis. We wish to broaden the scope of such methods by moving beyond the study of individuals and their activities to also include the relationship between locative media and aesthetic experiences that they engage with as users/readers/listeners of audiowalks.
description: Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media, No 8 (2024): Mobile Locative Media and Hybrid Narrative Spaces & Other Essays
Knowledge, Attitude and Perception of Military Doctors on Adverse Drug Reaction (ADR) Reporting in Myanmar
Creators: name: Htoon, Kyaw Zwar
name: Lynn, Thurein
name: Sohn, Pyae
name: Kyaing, Khin Ohnmar
Publisher: name: Zenodo
Year: 2017
Subjects: subject: Adverse drug reactions
subject: adverse drug reaction (ADR)
subject: Reporting
subject: Military doctors

description: Adverse drug reaction (ADR) reporting is very useful for assessment of benefit-risk ratio of some drugs and detection of unexpected and uncommon adverse drug reactions which are not seen in the initial evaluation process of a drug. However, under-reporting of ADRs by health care professionals is still a main problem in most of the countries. The aim of this study was to evaluate the knowledge, attitude and perception of military doctors on ADR reporting system in Myanmar. Type of study was cross sectional descriptive study and 44 military doctors with minimum qualification of MBBS were approached with prevalidated questionaires. All the participants responded, and nearly all the doctors have experience of some ADRs but  they have never reported these adverse events. All of the participants believed that ADR reporting is beneficial to health care system. Busy shedule, not knowing whom to report, difficulty to admit harm to the patient, thinking that one report doesn't make any difference and assuming only safe drugs are available in the market were some of the reasons why they do not report ADR. According to the results, ADR reporting system awareness and practice should be encouraged in Myanmar.