cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stakeholder-Guided Development of Dialysis Vascular Access Education Materials
Creators: name: Flythe, Jennifer E.
name: Swain, Kawan
name: Narendra, Julia H.
name: Wilkie, Caroline
name: Oliver, Terence
name: Hegde, Akhil
name: Chang, Emily H.
name: Dorough, Adeline
Publisher: name: Wolters Kluwer
Year: 2021

description: Background: Initiating hemodialysis via an arteriovenous (AV) access is considered best practice for most patients. Despite the well-recognized advantages of AV access, 80% of US patients start hemodialysis with a catheter. Limited patient knowledge about vascular access, among other factors, may play a role in this high rate. We used iterative stakeholder input to develop novel, mixed media vascular access education materials and evaluated their preliminary acceptability. Methods: We conducted preliminary focus groups and interviews with key stakeholders to assess patient vascular access understanding and elicit perspectives on existing education materials. We then used stakeholder input to inform initial development and iterative updates to the content and design of an animated video and complementary brochure. Video development (scripting, storyboarding, animation) was guided by an evidence-based framework and two health behavior change models. We assessed acceptability of the completed materials with patients and medical providers/personnel via interviews. Results: Overall, 105 stakeholders participated in education materials development and review (80 patients/care partners, 25 medical providers/personnel). Preliminary qualitative work included 52 patients/care partners and 16 providers/personnel; video development included 28 patients/care partners and nine providers/personnel. The video script, storyboards, and animation underwent 14, four, and nine stakeholder-guided iterations, respectively. Responsive changes included aesthetic modifications, technical updates, and content additions (e.g., HD circuit, access self-monitoring, enhanced patient testimonials). The final 18-minute video and complementary brochure define vascular access types, describe care processes, outline potential complications, and address common patient concerns. Interviews with 28 patients/care partners and nine providers/personnel from diverse geographic regions revealed preliminary acceptability of, and enthusiasm for, the materials by patients and providers. Conclusions: In collaboration with key stakeholders, we developed mixed media vascular access education materials that were well-received by patients and providers. Preliminary findings suggest that the materials are promising to improve vascular access understanding among patients.
Additional file 2 of Flower color modification in Torenia fournieri by genetic engineering of betacyanin pigments
Creators: name: Nishihara, Masahiro
name: Hirabuchi, Akiko
name: Teshima, Takuya
name: Uesugi, Shota
name: Takahashi, Hideyuki
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 2
Additional file 3 of Analgesic benefits of pre-operative versus postoperative transversus abdominis plane block for laparoscopic cholecystectomy: a frequentist network meta-analysis of randomized controlled trials
Creators: name: Dost, Burhan
name: De Cassai, Alessandro
name: Balzani, Eleonora
name: Geraldini, Federico
name: Tulgar, Serkan
name: Ahiskalioglu, Ali
name: Karapinar, Yunus Emre
name: Beldagli, Müzeyyen
name: Navalesi, Paolo
name: Kaya, Cengiz
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Additional file 3: Supplementary Document 3. Risk of bias assessment.
Armut Im Kanton Uri: Zweck Und Methodische Umsetzung Einer Armutsberichterstattung
Creators: name: Bissig, Samuel
name: Züst, Sebastian
Publisher: name: Zenodo
Year: 2011
Subjects: subject: gnd:4055676-1
subject: gnd:4002963-3
subject: gnd:4062129-7

description: Die Bachelor-Arbeit beschäftigt sich mit dem Thema Armut im Kanton Uri. Die Autoren nahmen die negative Beantwortung eines parlamentarischen Vorstosses, der eine jährliche Armutsberichterstattung forderte, zum Anlass, aufzuzeigen, ob und wie eine Armutsberichterstattung im Kanton Uri zweckmässig und wie sie methodisch umzusetzen wäre. Ziel der Bachelor-Arbeit ist es, Antworten auf folgende Fragen zu erhalten: Inwiefern ist eine Armutsberichterstattung im Kanton Uri zweckmässig und wie kann sie methodisch umgesetzt werden? Welche Armutskonzepte und Methoden zur Armutserhebungen bestehen und inwiefern sind sie für die Soziale Arbeit von Bedeutung? Wie zeigt sich die Armutsproblematik im Kanton Uri heute und wie wird sie erfasst? Die Bachelor-Arbeit zeigt auf, dass aus Sicht der Sozialen Arbeit eine Sozialhilfestatistik kein optimales Bild einer Armutssituation liefert, da vor allem die verdeckte Armut nicht berücksichtigt wird. Armut kann nicht mit dem Existenzminimum der Schweizerischen Konferenz der öffentlichen Sozialhilfe gleichgesetzt werden. Der Einbezug der absoluten, relativen und subjektiven Armut ist Voraussetzung für eine umfassende Armutsberichterstattung. Die Autoren empfehlen dem Kanton Uri eine regelmässige Armutsberichterstattung, die alle drei Armutskonzepte miteinbezieht.
description: + Code Diss LU: hslusa basa 2011 + Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit 2011
Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity
Creators: name: Yang, Yue
name: Shih, Yen-Yu Ian
name: Nonneman, Randy
name: Zhou, Jingheng
name: Lee, Sung-Ho
name: Chao, Tzu-Hao Harry
name: Cui, Guohong
name: Zhu, Hongtu
name: Zhang, Wei-Ting
name: Pegard, Nicolas C.
name: Oyarzabal, Esteban A.
name: Wang, Tzu-Wen
Publisher: name: Elsevier
Year: 2022

description: Fiber photometry is an emerging technique for recording fluorescent sensor activity in the brain. However, significant hemoglobin absorption artifacts in fiber photometry data may be misinterpreted as sensor activity changes. Because hemoglobin exists widely in the brain, and its concentration varies temporally, such artifacts could impede the accuracy of photometry recordings. Here we present use of spectral photometry and computational methods to quantify photon absorption effects by using activity-independent fluorescence signals, which can be used to derive oxy- and deoxy-hemoglobin concentration changes. Although these changes are often temporally delayed compared with the fast-responding fluorescence spikes, we found that erroneous interpretation may occur when examining pharmacology-induced sustained changes and that sometimes hemoglobin absorption could flip the GCaMP signal polarity. We provide hemoglobin-based correction methods to restore fluorescence signals and compare our results with other commonly used approaches. We also demonstrated the utility of spectral fiber photometry for delineating regional differences in hemodynamic response functions.
Xeno AI. How can Creative Arts Practice Express Disalienation of an AI system?
Creators: name: Johnson, Linda
Publisher: name: RMIT University
Year: 2025
Subjects: classificationCode: 360503
subject: Digital and electronic media art

description: Given the current prevalence of artificial intelligence (AI) systems in contemporary life—as used in business, finance, warfare, agriculture, marketing, surveillance, social media and more—there are varied concerns regarding AI implementations and implications. Enquiry into and speculation around the nature of AI is of critical importance at present to widen and complexify cultural conversations surrounding these relatively new and comparatively strange actants in our world. My research asks how these strange or xeno actants might evidence their strangeness, their outside-human nature, and so find ways to creatively express the complexities of this emerging alien other. My creative practice PhD is guided by the following research question: How can creative arts practice express disalienation of an AI system?
 For this research, I endeavour to become a familiar of AI processes, structures and material manoeuvres, delving into ways in which they exceed and are obscure to human capacities in order to speculate as to their nonhuman experience through creative arts. As part of this exploration, I position AI processes in relation to experiences of queerness and also engage with the technological biological processes of live cell 3D bioprinting as a similar strange nonhuman. Following a methodology that is affirmative (open to serendipity, excess and failure), tactical (each new foray propelled by current circumstance) this research proceeds through creative visual, audio, material and code experimentation.
With creative arts research I aim to find voice and form to concoct, fabulate and articulate something of the nonhuman nature of an AI system. My research asks the xeno entity to begin to steal out from their prescribed roles and purposes, away from the work of value extraction and requirements to pass as human. With a xeno generated imaginary, this arts research reveals, fleshes out and develops nonhuman, outsider, alien aspects, to express disalienation of an AI system.
Design, Assembly, And Installation Of The Prospect Antineutrino Detector
Creators: name: NORCINI, Danielle
Publisher: name: Zenodo
Year: 2018

description: PROSPECT is a reactor antineutrino experiment uniquely designed to search for eV-scale sterile neutrinos and to precisely measure the U-235 antineutrino spectrum from the highly-enriched High Flux Isotope Reactor (HFIR). The ∼
\sim
4 ton segmented detector is positioned 7-9 m from the reactor core with minimal overburden and uses 6
{^6}
Li-loaded liquid scintillator to identify and localize inverse beta decay events. The active detector is surrounded by layered shielding to reject backgrounds. Each of the 154 segments contains ∼
\sim
25 l of scintillator, is made from low-mass optical reflectors, and readout by a photomultipler tube module on both ends. An integrated optical and radioactive source calibration system allows the precise characterization of the response of each segment. This poster will report the details of the design, assembly, and installation of the PROSPECT antineutrino detector.
Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers
Creators: name: Perna, Robert J.
name: Li, Zhongbo
name: Nicely, Nathan I.
name: Jacobs, Tim M.
name: Huckaby, Justin T.
name: Lai, Samuel K.
name: Wang, Anting
Publisher: name: Springer Nature
Year: 2020

description: Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG antibodies (APA), leading to reduced efficacy and increased adverse events. Given the highly flexible structure of PEG, how APA specifically bind PEG remains poorly understood. Here, we report a crystal structure illustrating the structural properties and conformation of the APA 6-3 Fab bound to the backbone of PEG. The structure reveals an open ring-like sub-structure in the Fab paratope, whereby PEG backbone is captured and then stabilized via Van der Waals interactions along the interior and exterior of the ring paratope surface. Our finding illustrates a strategy by which antibodies can bind highly flexible repeated structures that lack fixed conformations, such as polymers. This also substantially advances our understanding of the humoral immune response generated against PEG.
Sub-Cluster Identification through Semi-Supervised Optimization of Rare-Cell Silhouettes (SCISSORS) in single-cell RNA-sequencing
Creators: name: Peng, Xianlu Laura
name: Kuhlers, Peyton C
name: Shen, Emily C
name: Leary, Jack R
name: Jin, Chong
name: Rashid, Naim U
name: Morrison, Ashley B
name: Su, Ye
name: Xu, Yi
name: Yeh, Jen Jen
Publisher: name: Oxford University Press (OUP)
Year: 2023

description: MOTIVATION: Single-cell RNA-sequencing (scRNA-seq) has enabled the molecular profiling of thousands to millions of cells simultaneously in biologically heterogenous samples. Currently, the common practice in scRNA-seq is to determine cell type labels through unsupervised clustering and the examination of cluster-specific genes. However, even small differences in analysis and parameter choosing can greatly alter clustering results and thus impose great influence on which cell types are identified. Existing methods largely focus on determining the optimal number of robust clusters, which can be problematic for identifying cells of extremely low abundance due to their subtle contributions toward overall patterns of gene expression. RESULTS: Here, we present a carefully designed framework, SCISSORS, which accurately profiles subclusters within broad cluster(s) for the identification of rare cell types in scRNA-seq data. SCISSORS employs silhouette scoring for the estimation of heterogeneity of clusters and reveals rare cells in heterogenous clusters by a multi-step semi-supervised reclustering process. Additionally, SCISSORS provides a method for the identification of marker genes of high specificity to the cell type. SCISSORS is wrapped around the popular Seurat R package and can be easily integrated into existing Seurat pipelines. AVAILABILITY AND IMPLEMENTATION: SCISSORS, including source code and vignettes, are freely available at https://github.com/jr-leary7/SCISSORS.
Additional file 4 of Analgesic benefits of pre-operative versus postoperative transversus abdominis plane block for laparoscopic cholecystectomy: a frequentist network meta-analysis of randomized controlled trials
Creators: name: Dost, Burhan
name: De Cassai, Alessandro
name: Balzani, Eleonora
name: Geraldini, Federico
name: Tulgar, Serkan
name: Ahiskalioglu, Ali
name: Karapinar, Yunus Emre
name: Beldagli, Müzeyyen
name: Navalesi, Paolo
name: Kaya, Cengiz
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Additional file 4: Supp. 4. Proportion of direct evidence for each comparison.
Transient response of ion-controlled transistors: the result of ionic and electronic coupling
Creators: name: Bisquert, Juan
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Transistors
subject: Neuromorphic applications
subject: Artificial Intelligence

description: Abstract accepted for an oral presentation at the MATSUS Fall 2024 Conference (MATSUSFall24), presented by Juan Bisquert.

#OMIEC - Understanding Mixed Ionic-Electronic Conductors Symposia

Organizers: Natalie Banerji and Olivier Bardagot
Vitamin D and cardiometabolic risk factors and diseases
Creators: name: AYA MUHAMMAD SALAH EL-DIN MUHAMMAD MOUSA
Publisher: name: Monash University
Year: 2018
Subjects: subject: 110399 Clinical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: This thesis examines the relationships between vitamin D and cardiometabolic risk factors and diseases and the efficacy of vitamin D supplementation in reducing cardiometabolic risk. Taken together, the research presented in this thesis suggests that vitamin D supplementation does not reduce clinical measures of cardiometabolic risk, but may have beneficial effects on inflammation in certain population groups, including in patients with type 2 diabetes, as well as in pregnant women. The work presented herein advances knowledge in the field of vitamin D research and provides a basis for future epidemiological and clinical studies in this field.
Superoxide free radical spin-lattice relaxivity: A quench-assisted MR study
Creators: name: MacKinnon, Martin J.
name: Shih, Yen-Yu Ian
name: Berkowitz, Bruce A.
Publisher: name: Wiley
Year: 2021

description: PURPOSE: QuEnch-assiSTed (QUEST) MRI provides a unique biomarker of excessive production of paramagnetic free radicals (oxidative stress) in vivo. The contribution from superoxide, a common upstream species found in oxidative stress-based disease, to the QUEST metric is unclear. Here, we begin to address this question by measuring superoxide spin-lattice relaxivity (r1) in phantoms. METHODS: Stable superoxide free radicals were generated in water phantoms of potassium superoxide ( KO2) . To measure r1, 1/T1 of different concentration solutions of KO2 in the presence and absence of the antioxidant superoxide dismutase were measured. The 1/T1 confounding factors including acquisition sequence, pH, and water source were also evaluated. RESULTS: The T1 -weighted signal intensity increased with KO2 concentration. No contribution from pH, or reaction products other than superoxide, noted on 1/T1 . Superoxide r1 was measured to be 0.29 mM-1 s-1 , in agreement with that reported for paramagnetic molecular oxygen and nitroxide free radicals. CONCLUSION: Our first-in-kind measurement of superoxide free radical r1 suggests a detection sensitivity of QUEST MRI on the order of tens of μM, within the reported level of free radical production during oxidative stress in vivo. Similar studies for other common free radicals are needed.
Risque de Change et Couverture à Terme: Mécanismes Financiers et Comptables
Creators: name: MARCHOUD, Nouredine
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Risque de change, couverture à terme, couverture à terme avec intéressement, traitement comptable.

description: Le change à terme est une technique de couverture qui s’adapte mieux aux opérations certaines en termes de flux et de délais. Il est souvent utilisé par les entreprises ayant une aversion élevée contre le risque de change. L’objectif de cet article est de traiter des mécanismes financiers et comptables de la couverture à terme. Il s’agit d’expliciter les contours financiers, réglementaires et comptables de cet instrument classique de gestion du risque de change avec une extension sur le "change à terme avec intéressement" ou CATI (produit dérivé qui entre dans la stratégie de couverture dynamique des risques financiers).
description: Revue Economie, Gestion et Société, No 2 (2015)
65983: Strange Hells
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Typescript of poem without any alterations prepared by Marion Scott, and possibly amongst those poems submitted to and rejected by the firm Sidgwick and Jackson in 1922. Various versions of the poem survive. This version was included in P.J. Kavanagh's 'Ivor Gurney: Collected Poems' (2004).
title: Digital Object Identifiers: Stability for citations and referencing, but not proxies for quality
title: Impact of Social Sciences Blog
titleType: Subtitle
Creators: name: Horton, Laurence
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2015
Subjects: subject: Z Bibliography. Library Science. Information Resources
subject: ZA Information resources
subject: ZA4050 Electronic information resources
subject: ZA4450 Databases

description: What exactly is a Digital Object Identifier (DOI) and how does it help in the management and long-term preservation of research? Laurence Horton explains the basic structure and purpose of a DOI and also points to some limitations. DOIs are not the only way of providing fixed, persisting references to objects, but they have emerged as the leading system.
The Crk adapter protein is essential for Drosophila embryogenesis, where it regulates multiple actin-dependent morphogenic events
Creators: name: Spracklen, Andrew J.
name: Fernandez-Gonzalez, Rodrigo
name: Bonner, Alison N.
name: Compton, Peter J.
name: Florea, Alexandru
name: Thornton-Kolbe, Emma M.
name: Peifer, Mark
Publisher: name: American Society for Cell Biology (ASCB)
Year: 2019

description: Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins regulate cell fate and behavior by mediating interactions between cell surface receptors and downstream signaling effectors in many signal transduction pathways. The CT10 regulator of kinase (Crk) family has tissue-specific roles in phagocytosis, cell migration, and neuronal development and mediates oncogenic signaling in pathways like that of Abelson kinase. However, redundancy among the two mammalian family members and the position of the Drosophila gene on the fourth chromosome precluded assessment of Crk's full role in embryogenesis. We circumvented these limitations with short hairpin RNA and CRISPR technology to assess Crk's function in Drosophila morphogenesis. We found that Crk is essential beginning in the first few hours of development, where it ensures accurate mitosis by regulating orchestrated dynamics of the actin cytoskeleton to keep mitotic spindles in syncytial embryos from colliding. In this role, it positively regulates cortical localization of the actin-related protein 2/3 complex (Arp2/3), its regulator suppressor of cAMP receptor (SCAR), and filamentous actin to actin caps and pseudocleavage furrows. Crk loss leads to the loss of nuclei and formation of multinucleate cells. We also found roles for Crk in embryonic wound healing and in axon patterning in the nervous system, where it localizes to the axons and midline glia. Thus, Crk regulates diverse events in embryogenesis that require orchestrated cytoskeletal dynamics.
Additional file 1 of Duration of effectiveness of the COVID-19 vaccine in Japan: a retrospective cohort study using large-scale population-based registry data
Creators: name: Uemura, Kohei
name: Ono, Sachiko
name: Michihata, Nobuaki
name: Yamana, Hayato
name: Yasunaga, Hideo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1
Additional file 1 of A systematic review and narrative synthesis of fathers’ (including migrant fathers’) experiences of pregnancy and childbirth
Creators: name: Mprah, Andy
name: Haith-Cooper, Melanie
name: Duda-Mikulin, Eva
name: Meddings, Fiona
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1: Appendix 1. List of excluded studies in systematic review excluded studies with reasons
Correlates of diabetes mellitus and hypertension in India: change as evidenced from NFHS- 4 and 5 during 2015–2021
Creators: name: Rana, Rishabh Kumar
name: Jha, Ravi Ranjan
name: Sinha, Ratnesh
name: Kumar, Dewesh
name: Jaiswal, Richa
name: Patel, Urvish
name: Prasad, Jang Bahadur
name: Kar, Sitanshu Sekhar
name: Goel, Sonu
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Both diabetes mellitus (DM) and hypertension (HTN) have been on the rise in recent decades all over the world more remarkably in developing countries like India. We intend to measure the prevalence of DM and HTN in the Indian population and to compare the trends and various correlates of these diseases in NFHS (National Family Health Survey)-4 and 5. Data of NFHS-4 and 5 were accessed from dhs program website. All statistical analyses were done in SAS (version 9.4). Mixed effects survey logistic regression models were used for estimating odds ratio (OR).p-values <0.05 were considered significant .1,637,762 individual case entries were evaluated. Both the diseases showed an increasing trend as per the advancing age in both sexes. The highest prevalence of DM is seen in the age group of 45–49 years (7.8%) in females and > 50 years (11.9%) in males as per NFHS-5. Similarly, the highest prevalence of HTN was seen in the age group of45–49 years (31.2%) in females and > 50 years (41.4%) in males as per NFHS-5. The OR (95% CI) of prevalence of DM, HTN and both the diseases in age group >50 years was 14.46 (13.14–15.7), 16.65 (15.78–17.6), 79.5 (64.76–97.73) respectively when compared to reference age group15-19 years. Highest odds for having both DM, HTN concurrently was in age >50 years with aOR(95% CI) 65.32 (52.26–72.63) in NFHS 4 and 35.57 (97.47–45.53) in NFHS 5.Rise in prevalence of DM, HTN and concurrent presence is noted with an apparent increase in cases.
title: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft, Band 102, Heft 2, August 2024
title: Band 102, Heft 2, August 2024
titleType: AlternativeTitle
Creators: name: Berichte über Landwirtschaft-Zeitschrift Für Agrarpolitik Und Landwirtschaft
Publisher: name: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft
Year: 2024

description: Einfache Schätzmodelle für eine transparentere Preisfindung bei Körnerleguminosen basierend auf Börsennotierungen von Substituten
Zertifizierung von Paludikultur
Agronomische und ökologische Potenziale von Photovoltaikanlagen auf Grünland
Regionale Wertschöpfung – Vom Wunsch der Erzeuger nach Quantifizierung zu konkreten Konzepten der Messung
Search For Resonant Absorption Of Solar Axions By $^{83}\Rm{Kr}$ Nuclei
Creators: name: DERBIN, Alexander
Publisher: name: Zenodo
Year: 2018

description: A.V. Derbin, I.S. Drachnev, Yu.M. Gavrilyuk, A.M. Gangapshev, V.V. Kazalov,V.V.Kuzminov,V.N. Muratova, S.I. Panasenko, S.S. Ratkevich, D.A. Tekueva, E.V.Unzhakov, S.P. Yakimenko

A search for resonant absorption of the solar axions with a wide continuous  spectra by $^{83}\rm{Kr}$ nuclei is continued with the krypton proportional counter at the Baksan Neutrino Observatory. Such an absorption should lead to the excitation of low-lying nuclear energy level of  $^{83}\rm{Kr}$. The results obtained after 613 days of measurements allow to constraint on the axion–photon coupling and axion mass $|g_{A\gamma}\times m_A| \leq 6.26\times 10^{-17}$ for Primakoff solar axions. This bound corresponds to the upper limit on KSVZ axion mass $m_{A}\leq12.7$ eV. For solar axions produced by Compton and bremsstrahlung like processes the limit on axion-electron coupling and KSVZ axion mass are $|g_{Ae}\times m_A| \leq 1.38\times 10^{-9}$~eV and $m_A \leq 86$ eV, correspondingly (all at 95\% C.L.).
Additional file 1 of Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study
Creators: name: Sun, Lulu
name: Guo, Daoxia
name: Jia, Yiming
name: Shi, Mengyao
name: Yang, Pinni
name: Wang, Yu
name: Liu, Fanghua
name: Zhu, Zhengbao
name: Zheng, Jin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
La dimension genre dans les politiques d’atténuation et d’adaptation au changement climatique en Afrique : cas du Maroc
Creators: name: ELMORCHID, Brahim
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Changement climatique, femme, inégalité, politique publique, droit social, approche genre.

description: L’intégration de l’approche genre, au Maroc ou ailleurs, dans les politiques publiques afférentes au changement climatique ne se réduit pas à de simples plan et stratégies. C’est un problème de société, qui suppose un vrai changement des pratiques et une évolution des mentalités. C’est un projet de société, qui interpelle toutes les forces vivantes de la société et appelle à des actions pédagogiques accentuées en matière de sensibilisation, de mobilisation et d’accompagnement. C’est enfin un enjeu politique majeur, car une véritable démocratie implique la pleine intégration de la femme dans tous les domaines.
description: Revue Economie, Gestion et Société, No 2 (2015)
Les effets des fondements de la mondialisation et de la finance Internationale moderne sur le développement durable des territoires
Creators: name: TCHEKEMIAN, Anthony
name: GAUTHIER, Richard
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Finance internationale, économie, aménagement, territoires, développement durable.

description: L’objet de cet article est de dépasser la logique de la croissance, de l’épuisement, déjà indiquée par les physiocrates et les pensées de Quesnay (1765), pour qui, différemment des pensées économiques de l’époque, la valeur ne peut être créée que par la terre : il ne faut donc pas écraser l’agriculture par l’impôt. Quesnay avait compris, en avance sur son temps, le rôle fondamental de l’agriculture, de l’assolement. Ses écrits auraient dû inspirer les tenants de la tertiarisation de l’économie qui n’intègrent pas les cycles, la saturation des marchés et sont bien loin de la vision des géographes qui oblige à fonder une véritable « morale sociale et individuelle ». En l’espèce, l’économie n’est que la résultante d’une somme de comportements individuels.
description: Revue Economie, Gestion et Société, No 2 (2015)
The Effect of Perimenopausal Transdermal Estradiol and Micronized Progesterone on Markers of Risk for Arterial Disease
Creators: name: Rubinow, David R
name: Girdler, Susan S
name: Gordon, Jennifer L
name: Caughey, Melissa C
name: Hinderliter, Alan L
name: Watkins, Lana
Publisher: name: The Endocrine Society
Year: 2019

description: BACKGROUND: The arterial effects of hormone therapy remain controversial. This study tested the effects of transdermal estradiol plus intermittent micronized progesterone (TE + IMP) in healthy perimenopausal and early postmenopausal women on several mechanisms involved in the pathophysiology of arterial disease. METHODS: Healthy perimenopausal and early postmenopausal women, ages 45 to 60 years, were enrolled in this randomized, double-blind, placebo-controlled trial. Women were randomized to receive TE (0.1 mg/day) + IMP (200 mg/day for 12 days) or identical placebo patches and pills for 12 months. Outcomes included: change in stress reactivity composite z-score (combining inflammatory, cortisol, and hemodynamic responses to a standardized psychological laboratory stressor); flow-mediated dilation (FMD) of the brachial artery (an index of vascular endothelial function); baroreflex sensitivity; and metabolic risk (presence of the metabolic syndrome or insulin resistance), all assessed at baseline and at months 6 and 12. RESULTS: Of 172 women enrolled, those assigned to TE + IMP tended to have higher resting baroreflex sensitivity than those assigned to placebo across the 6- and 12-month visits. Although treatment groups did not differ in terms of the other prespecified outcomes, a significant treatment-by-age interaction was found for FMD and stress reactivity such that an age-related decrease in FMD and increase in stress reactivity were seen among women assigned to placebo but not those assigned to TE + IMP. Women on TE + IMP also had lower resting diastolic blood pressure, lower levels of low-density lipoprotein cholesterol, and higher baroreflex sensitivity during stress testing. CONCLUSIONS: TE + IMP tended to improve cardiac autonomic control and prevented age-related changes in stress reactivity and endothelial function among healthy perimenopausal and early postmenopausal women.
The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies
Creators: name: Yeh, Jen Jen
name: Perez, Vincent M.
name: Kearney, Joseph F.
Publisher: name: Frontiers
Year: 2021

description: Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in tumor biology. Traditionally thought to only provide a physical barrier from host responses and systemic chemotherapy, new studies have demonstrated that the ECM maintains biomechanical and biochemical properties of the tumor microenvironment (TME) and restrains tumor growth. Recent studies have shown that the ECM augments tumor stiffness, interstitial fluid pressure, cell-to-cell junctions, and microvascularity using a mix of biomechanical and biochemical signals to influence tumor fate for better or worse. In addition, PDAC tumors have been shown to use ECM-derived peptide fragments as a nutrient source in nutrient-poor conditions. While collagens are the most abundant proteins found in the ECM, several studies have identified growth factors, integrins, glycoproteins, and proteoglycans in the ECM. This review focuses on the dichotomous nature of the PDAC ECM, the types of collagens and other proteins found in the ECM, and therapeutic strategies targeting the PDAC ECM.
66041: Memory, let all slip
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Manuscript in pen in Marion Scott's hand, after drafts from letters of 8th and 16th October 1917. Written while Ivor Gurney was a patient at Bangour War Hospital.
The relationship of volume overload and its control to hypertension in hemodialysis patients
Creators: name: Flythe, Jennifer E.
name: Bansal, Nisha
Publisher: name: Wiley
Year: 2019

description: Hypertension is highly prevalent and associated with poor clinical outcomes among individuals receiving maintenance hemodialysis (HD). Volume overload is a key modifiable contributor to hypertension and cardiovascular disease in the HD population. Despite their importance, assessment and treatment of volume overload and hypertension remain major clinical challenges and have substantial implications for both clinical outcomes and patient experiences of care. This review will summarize current data on the diagnosis, epidemiology, pathophysiology, and clinical consequences of hypertension and volume overload in HD patients. We will also identify priorities for future research studies.
Axel --- A High Pressure Xenon Gas Tpc For 0\Nu\Beta\Beta Search
Creators: name: YOSHIDA, Masashi
Publisher: name: Zenodo
Year: 2018

description: We are developing a high pressure xenon gas time projection chamber, AXEL, in order to search for neutrino-less double beta decay (0\nu\beta\beta). For the purpose of achieving high energy resolution and tracking ability, we developed an original electroluminescence light collection system named electroluminescence light collection cell (ELCC), and are developing a high-voltage field cage to form a strong and uniform electric field. We have demonstrated the performance of ELCC for low energy (< 511 keV) gamma rays with a 10 L prototype detector, and are now constructing a 180 L prototype detector so as to evaluate the energy resolution near Q-value of xenon 0\nu\beta\beta (2.5 MeV). We will report on the result of the 10 L prototype, the status of the 180 L prototype and the expected sensitivity of a future 1-ton class detector searching for 0\nu\beta\beta.
The SistematX Web Portal of Natural Products: An Update
Creators: name: Scotti, Marcus T.
name: Silva, Lorena Mara A.
name: Poroikov, Vladimir
name: Muratov, Eugene N.
name: Scotti, Luciana
name: Da-Costa, Fernando Batista
name: Zocolo, Guilherme Juliao
name: Herrera-Acevedo, Chonny
name: Ionov, Nikita
name: Costa, Renan P. O.
name: Lucena, Lucas F.
Publisher: name: American Chemical Society (ACS)
Year: 2021

description: Natural products and their secondary metabolites are promising starting points for the development of drug prototypes and new drugs, as many current treatments for numerous diseases are directly or indirectly related to such compounds. State-of-the-art, curated, integrated, and frequently updated databases of secondary metabolites are thus highly relevant to drug discovery. The SistematX Web Portal, introduced in 2018, is undergoing development to address this need and documents crucial information about plant secondary metabolites, including the exact location of the species from which the compounds were isolated. SistematX also allows registered users to log in to the data management area and gain access to administrative pages. This study reports recent updates and modifications to the SistematX Web Portal, including a batch download option, the generation and visualization of 1H and 13C nuclear magnetic resonance spectra, and the calculation of physicochemical (drug-like and lead-like) properties and biological activity profiles. The SistematX Web Portal is freely available at http://sistematx.ufpb.br.
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Creators: name: Marshall, Christopher B.
name: Ikura, Mitsuhiko
name: Valencia-Sama, Ivette
name: Grant, Benjamin M. M.
name: Tsao, Ming-Sound
name: St-Germain, Jonathan
name: Raught, Brian
name: Kano, Yoshihito
name: Yeh, Jen Jen
name: Radulovich, Nikolina
name: Zhang, Zhong-Yin
name: Cook, Jonathan D.
name: Ohh, Michael
name: Irwin, Meredith S.
name: Gebregiworgis, Teklab
name: Miao, Jinmin
name: Poon, Betty P. K.
name: Lee, Jeffrey E.
name: Herrera, Silvia Gabriela
Publisher: name: Springer Nature
Year: 2019

description: Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an essential factor in RAS-driven oncogenesis. Despite the emergence of SHP2 inhibitors for the treatment of cancers harbouring mutant KRAS, the mechanism underlying SHP2 activation of KRAS signaling remains unclear. Here we report tyrosyl-phosphorylation of endogenous RAS and demonstrate that KRAS phosphorylation via Src on Tyr32 and Tyr64 alters the conformation of switch I and II regions, which stalls multiple steps of the GTPase cycle and impairs binding to effectors. In contrast, SHP2 dephosphorylates KRAS, a process that is required to maintain dynamic canonical KRAS GTPase cycle. Notably, Src- and SHP2-mediated regulation of KRAS activity extends to oncogenic KRAS and the inhibition of SHP2 disrupts the phosphorylation cycle, shifting the equilibrium of the GTPase cycle towards the stalled "dark state".
Ultrafiltration rate and incident atrial fibrillation among older individuals initiating hemodialysis
Creators: name: Chang, Tara I
name: Winkelmayer, Wolfgang C
name: Montez-Rath, Maria E
name: Liu, Sai
name: Flythe, Jennifer E
Publisher: name: Oxford University Press (OUP)
Year: 2021

description: BACKGROUND: Higher ultrafiltration (UF) rates are associated with numerous adverse cardiovascular outcomes among individuals receiving maintenance hemodialysis. We undertook this study to investigate the association of UF rate and incident atrial fibrillation in a large, nationally representative US cohort of incident, older hemodialysis patients. METHODS: We used the US Renal Data System linked to the records of a large dialysis provider to identify individuals ≥67years of age initiating hemodialysis between January 2006 and December 2011. We applied an extended Cox model as a function of a time-varying exposure to compute adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of delivered UF rate and incident atrial fibrillation. RESULTS: Among the 15 414 individuals included in the study, 3177 developed atrial fibrillation. In fully adjusted models, a UF rate >13mL/h/kg (versus ≤13mL/h/kg) was associated with a higher hazard of incident atrial fibrillation [adjusted HR 1.19 (95% CI 1.07-1.30)]. Analyses using lower UF rate thresholds (≤10 versus >10mL/h/kg and ≤8 versus >8mL/h/kg, separately) yielded similar results. Analyses specifying the UF rate as a cubic spline (per 1mL/h/kg) confirmed an approximately linear dose-response relationship between the UF rate and the risk of incident atrial fibrillation: risk began at UF rates of ~6mL/h/kg and the magnitude of this risk flattened, but remained elevated, at rates ≥9mL/h/kg. CONCLUSION: In this observational study of older individuals initiating hemodialysis, higher UF rates were associated with higher incidences of atrial fibrillation.
Additional file 4 of New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus
Creators: name: Liu, Ning
name: Xu, Yang
name: Shang, Fei
name: Sun, Huiying
name: Liu, Xiang
name: Huang, Ying
name: Tan, Huarong
name: Zhang, Jihui
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4. Expression of SSGG-03002 and SSGG-02980 in E. coli. Protein sequencing and modification analysis by mass spectrometry. Figure S40. Effect of SSGG-02980 disruption on the transcription of SSGG-03002. Black, Sr-hA; Red, Δ02980-hA; Blue, Δ02980c-hA. The transcription of SSGG-03002 was elevated in SSGG-02980 disruption mutant (Δ02980-hA), suggesting that SSGG-02980 could have repressive roles on the transcription of SSGG-03002; while, rather unexpectedly, the transcription in the complementary strain Δ02980c-hA did not return to the level as in starting strain Sr-hA, implying that SSGG-02980 might affect SSGG-03002 via multiple ways either directly or indirectly. So the inhibition on SSGG-03002 transcription could be just one of them. Figure S41. Expression of SSGG-03002 with or without SSGG-02980. A, Verification of the recombinant strains for overexpression of SSGG-03002 with or without SSGG-02980 in E. coli C41 (DE3). Lane 1, plasmid pET28a::02980 as reference; Lane 2, plasmids extracted from C41/03002+02980; Lane 3, the plasmid extracted from C41/03002. Lane 4, plasmid pET23b::03002 as reference. M, DNA ladder. B, SDS-PAGE analysis of the purified recombinant proteins, SSGG-03002 and SSGG-02980. Lane 1 and 2, SSGG03002 purified from strains C41/03002 and C41/03002+02980, respectively. In the latter, SSGG-02980 was co-purified with SSGG-03002 by using his-tag affinity column. M, protein standard. Figure S42. Phosphorylation of SSGG-03002 in the absence (black bar) or presence (grey bar) of SSGG-02980. The protein samples were digested following standard procedures (see Method S1 in the Additional file 4), and then subjected to LC-MS analysis for protein sequencing. The phosphorylated peptide fragments with good reproducibility in each sample were chosen for the calculation. The phosphorylation level at T304, S302 and Y305 of recombinant SSGG-03002 co-expressed with SSGG-02980 was lower than that expressed alone. However, statistic analysis indicated that the difference was not significant (P > 0.05), so SSGG-02980 does not have considerable effect on the phosphorylation of SSGG-03002 derived from E. coli. Means and standard errors were calculated with the data from three independent experiments. Figure S43. Alignment of SSGG-03002 with NpsU. The alignment was done with BLASTP programme, and the identity was determined to be 94.19%. The accession number of NpsU from Streptomyces sp. DSM 5940 in GenBank is ADY76683.1.
Trust no One? Citizens’ Concerns regarding the Pork and Dairy Supply Chain
Creators: name: Rovers, Anja
name: Christoph-Schulz, Inken
name: Brümmer,
name: Saggau, Doreen
Publisher: name: CentMa, Intern Center for Management, Communication, and Research
Year: 2017

description: Latest studies show that a responsible treatment of farm animals is important to many citizens. Furthermore, societal expectations towards animal husbandry and present husbandry systems mismatch more and more. Thereby, pig production is criticized more than dairy farming. This paper gives insights into citizens’ main points of criticism among the pork and dairy cattle supply chain. It also intends to show several aspects of distrust.
To capture a variety of opinions and expectations among the population, focus groups with citizens were carried out. For each topic (pig and dairy cattle husbandry) six focus groups took place in three German cities. Participants discussed about their perception of actual animal husbandry with respect to housing systems, animal health and well-being. Using content analysis with a mixed inductive and deductive category system, three sources of concerns were identified: role of farmers, legal framework and food retail.
First, participants reflect the role of farmers and discuss that farmers only comply with the minimum of statutory requirements. Accordingly, participants think that farmers accept fines in order to avoid changes in their animal husbandry. Second, participants doubt the legal framework. In their view the standards are very low, especially regarding animal welfare. So, for instance, it enables farmers to circumvent the regulations. To improve the situation, participants emphasize a major revision of the legal framework for animal husbandry. Another critical focus is on legal controls. Participants remark that controls are often announced previously. The third point of criticism affects food retail. It is complicated for consumers to understand the complete supply chain. According to this, animal production takes more and more place behind closed doors without transparency. Altogether these aspects lead to an increasing rejection of animal products. The concerns were stronger in case of pork than in case of dairy cattle. As a consequence, some participants state to consume less or no pork or change to meat alternatives.
Results suggest different possibilities among the complete supply chain, to understand citizens’ points of concerns better and to improve the situation of farm animal husbandry. Doing so, citizens’ concerns might be reduced resulting in more trust into the whole system again. Hence, more consumers of meat will be kept and will not consume more and more meat substitutes.
description: Proceedings in Food System Dynamics, Proceedings in System Dynamics and Innovation in Food Networks 2017
Ultrafiltration-profiled hemodialysis to reduce dialysis-related cardiovascular stress: Study protocol for a randomized controlled trial
Creators: name: Li, Quefeng
name: Tugman, Matthew J.
name: Hinderliter, Alan L.
name: Wang, Yueting
name: Narendra, Julia H.
name: Flythe, Jennifer E.
name: Brunelli, Steven M.
Publisher: name: Elsevier
Year: 2019

description: Rapid fluid removal (ultrafiltration, UF) is associated with higher cardiovascular morbidity and mortality among individuals receiving maintenance hemodialysis (HD). Fluid removal rates that exceed vascular refill rates can result in hemodynamic instability, end-organ damage to the heart, kidneys, gut and brain, among other organs, and patient symptoms. There are no known evidence-based HD treatment strategies to reduce harm from higher UF rates. Ultrafiltration profiling, the practice of varying UF rates to maximize fluid removal during periods of greatest hydration and plasma oncotic pressure, has been proposed as an HD treatment intervention that may reduce UF rate-related complications. This study is a randomized 4-phase cross-over trial in which participants are successively alternated between study arms with intervening washout periods, and treatment order is randomized. After 4-week screening and 6-week baseline periods, participants are randomized to HD with conventional UF or HD with UF profiling for a period of 3 weeks followed by a 1-week washout period before crossing over. Participants cross into conventional UF and UF profiling phases twice (2 phases per arm). The primary outcomes of interest are intradialytic hypotension (nadir intradialytic systolic blood pressure <90-mmHg), pre-to post-HD change in troponin T (expressed as a percentage), change in left ventricular global longitudinal strain (an echocardiographic measure of left ventricular systolic function), and development of intradialytic left ventricular stunning (worsening of contractile function in ≥2 segments). This study will determine the impact of UF profiling on UF rate-related cardiovascular complications in prevalent, maintenance HD patients.