cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding
Creators: name: Osickova, Adriana
name: Balashova, Nataliya
name: Masin, Jiri
name: Sulc, Miroslav
name: Roderova, Jana
name: Wald, Tomas
name: Brown, Angela C.
name: Koufos, Evan
name: Chang, En Hyung
name: Giannakakis, Alexander
name: Lally, Edward T.
name: Osicka, Radim
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Kingella kingae is a member of the commensal oropharyngeal flora of young children. Improvements in detection methods have led to the recognition of K. kingae as an emerging pathogen that frequently causes osteoarticular infections in children and a severe form of infective endocarditis in children and adults. Kingella kingae secretes a membrane-damaging RTX (Repeat in ToXin) toxin, RtxA, which is implicated in the development of clinical infections. However, the mechanism by which RtxA recognizes and kills host cells is largely unexplored. To facilitate structure-function studies of RtxA, we have developed a procedure for the overproduction and purification of milligram amounts of biologically active recombinant RtxA. Mass spectrometry analysis revealed the activation of RtxA by post-translational fatty acyl modification on the lysine residues 558 and/or 689 by the fatty-acyltransferase RtxC. Acylated RtxA was toxic to various human cells in a calcium-dependent manner and possessed pore-forming activity in planar lipid bilayers. Using various biochemical and biophysical approaches, we demonstrated that cholesterol facilitates the interaction of RtxA with artificial and cell membranes. The results of analyses using RtxA mutant variants suggested that the interaction between the toxin and cholesterol occurs via two cholesterol recognition/interaction amino acid consensus motifs located in the C-terminal portion of the pore-forming domain of the toxin. Based on our observations, we conclude that the cytotoxic activity of RtxA depends on post-translational acylation of the K558 and/or K689 residues and on the toxin binding to cholesterol in the membrane.
How Ligand Geometry Affects the Reactivity of Co(II) Cyclam Complexes
Creators: name: Iffland‐Mühlhaus, Linda
name: Battistella, Beatrice
name: Siegmund, Daniel
name: Ray, Kallol
name: Apfel, Ulf-Peter
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: O−O activation
subject: cobalt
subject: macrocyclic ligands
subject: ligand effects
subject: reaction mechanisms
subject: 540 Chemie und zugeordnete Wissenschaften

description: Cobalt complexes are extensively studied as bioinspired models for non-heme oxygenases as they facilitate both the stabilization and characterization of metal-oxygen intermediates. As an analog to the well-known Co(cyclam) complex Co{N4} (cyclam=1,4,8,11-tetraazacyclotetradecane), the CoII complex Co{i-N4} with the isomeric isocyclam ligand (isocyclam=1,4,7,11-tetraazacyclotetradecane) was synthesized and characterized. Despite the identical N4 donor set of both complexes, Co{i-N4} enables the 2e−/2H+ reduction of O2 with a lower overpotential (ηeff of 385 mV vs. 540 mV for Co{N4}), albeit with a diminished turnover frequency. Characterization of the intermediates formed upon O2 activation of Co{i-N4} reveals a structurally identified stable μ-peroxo CoIII dimer as the main product. A superoxo CoIII species is also formed as a minor product, as indicated by EPR spectroscopy. In further reactivity studies, the electrophilicity of these in situ generated Co−O2 species was demonstrated by the oxidation of the O−H bond of TEMPO−H (2,2,6,6-tetramethylpiperidin-1-ol) via a H atom abstraction process. Unlike the known Co(cyclam), Co{i-N4} can be employed in oxygen atom transfer reactions oxidizing triphenylphosphine to the corresponding phosphine oxide highlighting the impact of geometrical modifications of the ligand while preserving the ring size and donor atom set on the reactivity of biomimetic oxygen activating complexes.
title: Avascular osteonecrosis of distal humeral epiphysis
Creators: name: Gupta, Neeti
Publisher: name: EURORAD
Year: 2022
Subjects: subject: Musculoskeletal system
subject: Extremities
subject: Musculoskeletal bone
subject: Conventional radiography
subject: MR
subject: Ischaemia / Infarction
subject: Clinical Cases

description: Clinical History: 17-year-old male, known case of Acute Lymphoblastic leukaemia (ALL) on high dose steroids since one year, came with complaints of right elbow joint pain and restriction of movements since 3 months. MRI right elbow with screening of left elbow was done.

description: 17 years, male
Influence Of H+ Ions And Γ-Ray Irradiation On Multiferroic Bi0.8Ca0.2Mno3 Thin Films
Creators: name: K.S. Pugazhvadivu
name: K. Tamilarasan
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Additional file 1 of An M0 macrophage-related prognostic model for hepatocellular carcinoma
Creators: name: Zhang, Yiya
name: Zou, Ju
name: Chen, Ruochan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: TableS1. Macrophage_M0 related genes using Pearson’sanalysis. Table S2. M0RGs associatedwith the prognosis of patients with HCC in TCGA datasets using univariate Coxanalysis. Table S3. M0RGs associatedwith the prognosis of patients with HCC in ICGC datasets using univariate Coxanalysis. Figure S1. M0 macrophages inHCC. Figure S2. The CNV and mutationstatus of 35 M0RGs. A, The CNV status of 35 M0RGs. B, The mutation status of 35M0RGs. Figure S3. The best cutoff value to distinguish the high-and low-risk groups. Figure S4. Prognostic model of the test (GSE14520) cohort. Riskscore of the high and low groups. Heatmap of the expression of 2 M0RGs.Survival analysis of the high and low groups. The AUC of the ROC. M0RGs: M0macrophages-related genes; AUC: Area under curve; ROC: Receiver operatingcharacteristic curve. Figure S5. Thesurvival analysis of OLA1 were analyzed using the X-Tile software. Figure S6. The survival analysis ofATIC were analyzed using the X-Tile software. Figure S7.C-index for discrimination. Figure S8. The HCC patients with highrisk also had poor prognosis of OS with different clinical characters. Figure S9. Construction of the nomogram in the ICGC dataset. Thenomogram to predict the 3-year survival risk of HCC patients. Figure S10. The expression andprognosis of M0RGs in HCC. A, The survival analysis of HCC with high/low ATICand OLA1 in TCGA. B, The survival analysis of HCC with high/low ATIC and OLA1in ICGC. C, ATIC and D, OLA1 expression in immune cells using tSNE cluster webtool. E, The protein levels of OLA1 in HCC using HPA dataset. Figure S11. Schematic depictingthe construction of an M0 macrophage-related prognostic model forhepatocellular carcinoma.
Occupational and Nonoccupational Fatalities on U.S. Farms
Creators: name: Fritsch, Conrad F.
name: Fritsch, Conrad F.
Publisher: name: Unknown
Year: 1976
Subjects: subject: Labor and Human Capital
subject: Fatal accidents
subject: Fatalities
subject: Occupational fatalities
subject: Nonoccupational fatalities
subject: Farm accidents
subject: Farm labor force
subject: Farm population

description: Benchmark data for farm fatalities are developed and analyzed by region and age groups. During 1969-71, occupational fatality rates for farmers and hired farmworkers were between 23.5 and 28 per 100,000 workers. The fatality rate for all farm residents and workers in 1973 was 16.2 per 100,000 persons, down from 17.7 in 1967. Fatalities occur with much greater frequency to persons age 55 and over than to persons under age 55. A greater proportion of self-employed farmworkers are in this higher risk age category than are hired workers, implying that overall occupational fatality rates for self-employed operators are higher than for hired workers.
HIV screening education for healthcare providers
Creators: name: Prasad, Shipra
Publisher: name: No Publisher Supplied
Year: 2020

description: The CDC recommends that people from ages 13 to 64 get screened for HIV at least once in their lifetime. Despite the recommendations, some healthcare providers are not following the CDC recommendations for HIV screening. Major barriers to routine HIV screening include lack of knowledge and inadequate training among healthcare providers.Methodology: The project consisted of providing the healthcare provider education about HIV screening and implementing CDC recommended HIV screening to the practice over one month. The healthcare provider education consisted specifically of modes of transmission, long term effects of HIV, and CDC recommendations. The project consisted of seven participants, 148 retrospective and 148 prospective chart reviews. The design of this project is a one-group pre-test and post-test design coupled with retrospective and prospective chart reviews.Results: There was an insignificant increase in knowledge about HIV (p = 0.11) among healthcare providers, but a significant increase in HIV screening performed by healthcare providers (p < .0001). In the retrospective sample, 6 of 148 patients (4.1%) were offered the HIV test, and in the prospective sample, 132 of 148 patients (89.2%) were offered the HIV test. This indicates healthcare providers can identify people who are at risk for HIV and link to care. Implications: HIV screening will help healthcare workers identify people living with HIV by using the CDC protocol and help improve the quality of care and safety. Early screening and linkage to care help reduce the economic burden of HIV and AIDS by decreasing incidence and mortality and reducing transmission. HIV screening leads to more people being aware of their HIV status, which supports the New Jersey Taskforce to End the HIV Epidemic, tasked with ending the HIV epidemic by 2025.
Molecular Dynamics Simulations of MHCII-G1
Creators: name: Mixcoha, Edgar
name: Martinez Olivares, Constanza Estefania
Publisher: name: figshare
Year: 2022
Subjects: subject: Computational Chemistry
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences
subject: 30406 Proteins and Peptides
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified

description: Protein coordinates were centered in a dodecahedron box with a 1.5 nm distance between protein and unit cell walls. AMBER99SB was used as a force field to describe the whole system. Protein was solvated using the SPC water model. The system was neutralized by replacing water molecules until reaching 0.15 M NaCl mimicking physiological conditions. The neutralized system was energetically minimized for 1000 steps using the steepest descent algorithm. The system was equilibrated at 310 K with an NVT assembly for 1 ns. Subsequently, 5 ns of an NPT equilibration at 310 K and 1 atm of pressure was used.
“Poetry slam” em Portugal: disputas pós-coloniais
Creators: name: Pinheiro, Maria Giulia
name: Vidal, Saru
name: Agra De Brito Neves, Cynthia
Publisher: name: Confluenze.  Rivista di Studi Iberoamericani
Year: 2024

description: O presente artigo tem como propósito discutir e analisar postagens públicas na rede social Facebook que apontam opiniões xenófobas sobre a cena (i)migrante do poetry slam em Portugal. Tais postagens refletem posturas pós-coloniais de um país historicamente colonizador, que hoje experimenta uma crise cultural identitária que oscila entre a ideologia lusotropicalista e a eurocêntrica, e cuja discriminação econômica, racial e de gênero ainda se faz presente. Trataremos, portanto, do poetry slam em Portugal à luz de disputas pós-coloniais, identitárias e sociais.
description: Confluenze. Rivista di Studi Iberoamericani, Vol. 16 No. 1 (2024): Materiality on the Move. Agency, Meanings, and Circulation of Objects in the Americas
Supplemental Material
Creators: name: Teodorescu, Mihaela
name: Setzke
Publisher: name: figshare
Year: 2019
Subjects: subject: 60603 Animal Physiology - Systems
subject: FOS: Biological sciences

description: Online Supplemental Material for EFFECTS OF INHALED FLUTICASONE PROPIONATE ON EXTRINSIC TONGUE MUSCLES IN RATS manuscript.
A new subtype of eastern tick-borne encephalitis virus discovered in Qinghai-Tibet Plateau, China
Creators: name: Dai, Xiaoyi
name: Shang, Guobao
name: Lu, Shan
name: Yang, Jing
name: Xu, Jianguo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). Two complete genomes of TBEV were obtained from respiratory samples of 200 marmots. The phylogenetic analysis using the E protein and polyprotein demonstrated that the two strains of Him-TBEV formed an independent branch, separated from Eu-TBEV, Sib-TBEV, and FE-TBEV. The nomenclature of Him-TBEV as a new subtype was also supported by comparative analysis using nucleotide and amino acid sequences of E protein and polyprotein. For E protein, The Him-TBEV showed 82.6–84.6% nucleotide identities and 92.7–95.0% amino acid identities with other three subtypes. For polyprotein, the Him-TBEV showed 83.5–85.2% nucleotide identities and 92.6–94.2% amino acids identities with other three subtypes. Furthermore, of 69 amino acid substitutions profiles detected in complete polyprotein of 112 strains of TBEV, Him-TBEV subtype displayed unique amino acids in the 36 positions. Notably, for the subtype-specific amino acid position 206 of E protein, Him-TBEV shared the Val with Eu-TBEV, but differed from FE-TBEV and Sib-TBEV. The evolutionary analysis with BEAST suggested that Him-TBEV diverged from other subtypes of eastern TBEV group about 2469 years ago. It should be mentioned that Qinghai-Tibet Plateau in China is the plague endemic region where Marmota himalayana is the primary host. The public health significance of discovery of Him-TBEV in Marmota himalayana must be carefully evaluated.
Desviados, fabricados, dados vuelta: objetos subversivos en las Américas de los “años 1968”
Creators: name: Thomas, Jean Baptiste
Publisher: name: Confluenze. Rivista di Studi Iberoamericani
Year: 2024

description: Este artículo abordará tres eventos vinculados al “Global 68” en las Antillas francesas, en Argentina y en las Antillas neerlandesas, a través de los objetos que los manifestantes desvían de su uso “natural”, fabrican en talleres o, simplemente, dan vuelta para resistir a la represión. Pretende ver cómo estos objetos representan una novedad en el repertorio de acciones sesentayochista, hasta qué punto encarnan una continuidad con una trayectoria previa de insurgencia y qué revelan de las características intrínsecas de unas movilizaciones locales pero que se inscriben en una dinámica global.
description: Confluenze. Rivista di Studi Iberoamericani, Vol. 16 No. 1 (2024): Materiality on the Move. Agency, Meanings, and Circulation of Objects in the Americas
title: Diccionario Gramsciano (1926-1937)
Creators: name: Liguori, Guido
name: Modonesi, Massimo
name: Voza, Pasquale
name: Secci, Maria Cristina
Publisher: name: UNICApress
Year: 2022

description: Para la versión al español de este diccionario se seleccionaron 101 lemas de entre las voces que constituyen la columna vertebral del pensamiento de Gramsci en su periodo carcelario (1926-1937). La redacción de las entradas fue originalmente realizada privilegiando citas textuales, para sugerir una atención al texto que no siempre se encuentra en la crítica, y se mantuvo la secuencia cronológica que permite reconocer la estrategia del pensamiento y de la escritura de Gramsci en su cuadernos. La escritura de las voces aparece así, a los ojos del lector, lo más limpia posible, solo hilada por una intervención discreta de los autores y sin interferir con referencias a los debates entre las diversas interpretaciones existentes en la literatura sobre los puntos, aspectos y conceptos expuestos.
Additional file 1 of Work-related injuries among 5 – 17 years-old working children in Egypt: findings from a national child labor survey
Creators: name: Fouad, Ahmed Mahmoud
name: Amer, Shaimaa A. A. M.
name: Abdellatif, Yasser Omar
name: Elotla, Sally Fawzy
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. National Child Labour Survey 2010 Questionnaire.
QORAQAT O'SIMLIGI BARGLARINING TARKIBIDAGI ASKORBIN KISLOTASI VA ERKIN ORGANIK KISLOTALAR MIQDORINI ANIQLASH
Creators: name: Ortiqova, N.
name: Saidvaliyev, A.K.
Publisher: name: Zenodo
Year: 2024

description: Qoraqat (qora smorodina) - Ribus nigrum ko’p yillik shoxlangan buta bo’lib,  Saxifragáceae oilasiga mansub. Bo’yi 1-1,5 m bo’lib o’sadi. Barglari ketma-ket joylashgan bo’lib, o’ziga xos xidga ega. Gullari sariq-qizg’ish rangli bo’lib to’plangan, mevasi esa ko’p mayda urug’li bo’lib, qop-qora binafsha rangli mevasi yumaloq, may-iyun oylarida gullaydi, iyul-avgust oylarida pishib yetiladi. Qoraqat Rossiya va Qirg’iziston tog’  oldi xududlarida ko’p uchraydi. O’zbekiston sharoitida madaniylashtirib o’stiriladi. Mevasida asosan fruktoza, vitamin C (4000 mg%) vitaminlardan B, B2, E, K (7-12 mg%), flavanoidlar, flavanlar, katexinlar, leyoantosidlar, antosinlar (1100-1200 mg%), karotinlar (0,1103 mg%), organik kislotalardan limon, olma, salitsil, yantar, nikotin, fosfor kislotalari (4-5%), piktin moddalar (0,2-0,8%) ASK (365 mg%), temir (0,9 mg%), Cu, Mn, efir moylari (0,01%), dubil moddalar (0,39%), saxaroza, glikozidlar saqlaydi.
Deliverable 4.5 Scale-up of TAG production
Creators: name: Bio Base Europe
Publisher: name: Zenodo
Year: 2024

description: This deliverable describes the development of a production process for microbial oil in the form of triacylglycerol (TAG) at pilot scale. This process includes (i) the cultivation of Yarrowia lipolytica which accumulates TAG in intracellular lipid bodies (executed in BioSFerA task 4.4) and (ii) the downstream processing (DSP) of the fermentation broth to extract and purify the TAG oil (executed in BioSFerA task 4.5). The insights obtained during the lab scale developments of this process within BioSFerA workpackage 3 were used as a starting point for this scale-up. The purified oil will be used for upgrading within BioSFerA workpackage 5 and its quality should thus meet the requirements for hydrotreatment
title: Pulmonary nodules in Tularaemia
Creators: name: Tornič, Tajda
Publisher: name: EURORAD
Year: 2022
Subjects: subject: Chest imaging
subject: Lung
subject: Thorax
subject: CT-High Resolution
subject: Infection
subject: Clinical Cases

description: Clinical History: A 65-year-old male with a history of hypertension and prostate carcinoma in remission was referred to the emergency department. He presented with the following symptoms: high fever (up to 39.0oC), generalised weakness, joint pain and headache. His medications included the antihypertensive agent Perindopril Erbumine 4mg daily. 

description: 65 years, male
Communication, literacies, multilingual and critical thinking skills and competences for teaching and learning in the digital age
Creators: name: Janssen, Helen
Publisher: name: Zenodo
Year: 2021

description: Whenbringing together research, policy and practice, we aim to offer an analysis of various approaches and frameworks in order to identify new roles and necessary competences in the wide and intertwined fields of communication, literacies, multilingualism and critical thinking for teachers and school leaders in the context of the digital age. In this regard we are looking into both the relevant competences of teachers and school leaders as professional traits and the roles in and competences required for supporting skills and competences development in their students. This is specifically in the area of com munication, literacies and critical thinking, using multilingualism as a scaffold, in the context of the digital age in order to go beyond existing frameworks and research.We focus on the following areas within this broad concept:·School leaders’ and teachers’ competences, with the Key Competences for Lifelong LearningFramework and LifeComp at its core and specified for school leaders and teacher roles.·Teaching and learning for developing communication and critical thinking skill s andcompetences, multiple literacies and utilising multilingualism in the context of the digital age.
Additional file 2 of Work-related injuries among 5 – 17 years-old working children in Egypt: findings from a national child labor survey
Creators: name: Fouad, Ahmed Mahmoud
name: Amer, Shaimaa A. A. M.
name: Abdellatif, Yasser Omar
name: Elotla, Sally Fawzy
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Framework for identification of child labor (as described in the NCLS official report). Table S2. NCLS questionnaire items which were used to identify the work-related injuries. Table S3. NCLS questionnaire items which were used to identify working children. Table S4. Questions in NCLS questionnaire which describe the workplace hazards.
Roadmap on multimode photonics
Creators: name: Cristiani, I
name: Lacava, C
name: Rademacher, G
name: Puttnam, BJ
name: Luìs, RS
name: Antonelli, C
name: Mecozzi, A
name: Shtaif, M
name: Cozzolino, D
name: Bacco, D
name: Oxenløwe, LK
name: Wang, J
name: Jung, Y
name: Richardson, DJ
name: Ramachandran, S
name: Guasoni, M
name: Krupa, K
name: Kharenko, D
name: Tonello, A
name: Wabnitz, S
name: Phillips, DB
name: Faccio, D
name: Euser, Tijmen
name: Xie, S
name: Russell, PSJ
name: Dai, D
name: Yu, Y
name: Petropoulos, P
name: Gardes, F
name: Parmigiani, F
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Topical Review
nonlinear optics
multimode photonics
optical communications
optical nonlinearities
roadmap

description: Funder: Fundamental Research Funds for the Central Universities
description: Funder: Innovating City Planning through Information and Communication Technologies (INCIPICT)
description: Funder: Fiber Infrastructure for Research on Space-Division Multiplexed Transmission (FIRST)
description: Funder: Royal Academy of Engineering; doi: http://dx.doi.org/10.13039/501100000287
description: Abstract Multimode devices and components have attracted considerable attention in the last years, and different research topics and themes have emerged very recently. The multimodality can be seen as an additional degree of freedom in designing devices, thus allowing for the development of more complex and sophisticated components. The propagation of different modes can be used to increase the fibre optic capacity, but also to introduce novel intermodal interactions, as well as allowing for complex manipulation of optical modes for a variety of applications. In this roadmap we would like to give to the readers a comprehensive overview of the most recent developments in the field, presenting contributions coming from different research topics, including optical fibre technologies, integrated optics, basic physics and telecommunications.
Additional file 1 of Work-related injuries among 5 – 17 years-old working children in Egypt: findings from a national child labor survey
Creators: name: Mahmoud Fouad, Ahmed
name: Amer, Shaimaa A. A. M.
name: Abdellatif, Yasser Omar
name: Elotla, Sally Fawzy
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. National Child Labour Survey 2010 Questionnaire.
Dark Matter as a Bayesian Bias: A Proposed Gravitational Influence on Predictive Coding in Neural Systems
Creators: name: WILCOX, Clyde Jermaine
Publisher: name: Zenodo
Year: 2025

description: Description:

This paper presents a novel hypothesis proposing that dark matter (DM) density fluctuations exert subtle gravitational effects that influence neural predictive coding processes. Building on the Orch-OR theory and gravitational decoherence models, the hypothesis suggests that DM biasing Bayesian priors results in measurable perceptual errors. The proposed mechanism connects dark matter and brain function through gravitational interactions, challenging current models of perception and consciousness. A potential experimental design is outlined, focusing on correlating perceptual errors with mapped local dark matter density gradients.

 

This hypothesis bridges neuroscience and cosmology, offering a testable framework that could significantly impact both fields. It is highly speculative but grounded in falsifiable claims, with implications for understanding the nature of perception and consciousness.

 

Keywords: Dark Matter, Predictive Coding, Bayesian Inference, Quantum Biology, Orch-OR, Gravitational Decoherence, Neuroscience, Consciousness, Perception, Experimental Design
Additional file 2 of Work-related injuries among 5 – 17 years-old working children in Egypt: findings from a national child labor survey
Creators: name: Mahmoud Fouad, Ahmed
name: Amer, Shaimaa A. A. M.
name: Abdellatif, Yasser Omar
name: Elotla, Sally Fawzy
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Framework for identification of child labor (as described in the NCLS official report). Table S2. NCLS questionnaire items which were used to identify the work-related injuries. Table S3. NCLS questionnaire items which were used to identify working children. Table S4. Questions in NCLS questionnaire which describe the workplace hazards.
Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement
Creators: name: Duan, Xiaobing
name: Anwar, Muhammad Ikram
name: Xu, Zhanxue
name: Ma, Ling
name: Yuan, Guosheng
name: Chen, Yiyi
name: Liu, Xi
name: Xia, Jinyu
name: Zhou, Yuanping
name: Li, Yi-Ping
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development of the HCV replicon and its infectious clones. We and others have previously identified the p7 mutation F772S and the co-presence of NS4A mutations in infectious HCV full-length clones and chimeric recombinants. However, the underlying mechanism of F772S function remains incompletely understood. Here, we investigated the functional role of F772S using an efficient JFH1-based reporter virus with Core-NS2 from genotype 2a strain J6, and we designated J6-p7/JFH1-4A according to the strain origin of the p7 and NS4A sequences. We found that replacing JFH1-4A with J6-4A (wild-type or mutated NS4A) or genotype 2b J8-4A severely attenuated the viability of J6-p7/JFH1-4A. However, passage-recovered viruses that contained J6-p7 all acquired F772S. Introduction of F772S efficiently rescued the viral spread and infectivity titers of J6-p7/J6-4A, which reached the levels of the original J6-p7/JFH1-4A and led to a concomitant increase in RNA replication, assembly and release of viruses with J6-specific p7 and NS4A. These data suggest that an isolate-specific cooperation existed between p7 and NS4A. NS4A exchange- or substitution-mediated viral attenuation was attributed to the RNA sequence, and no p7-NS4A protein interaction was detected. Moreover, we found that F772S-enhanced p7-NS4A cooperation was associated with the enlargement of intracellular lipid droplets. This study therefore provides new insights into the mechanisms of adaptive mutations and facilitates studies on the HCV life cycle and virus–host interaction.
Additional file 10 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file10: Fig. S4: Light microscopy images of THP-1 cells exposed to MWCNT panel (10µg/ml) for 6 hours. Scale bar = 20µm.
Protocolo de revisão de escopo sobre estratégias para abordar a Judicialização da Saúde em sistemas de saúde universais
Creators: name: Araújo, BC
name: Araújo, DG
name: Scoton, MLRPD
name: Bastos, L
name: Andrade, NM
name: Marrone, PV
name: Bortoli, MC
name: Dias, EM
Publisher: name: Zenodo
Year: 2022
Subjects: Judicialização da Saúde
Adjudication of Health
Health's Judicialization

description: Protocolo de revisão de escopo sobre estratégias para abordar a Judicialização da Saúde em sistemas de saúde universais
Magnetic Properties Of Aluminum Doped Barium Hexagonal Ferrite
Creators: name: Shalini Govindaraj .
name: M Subha
name: A Arigsh
name: V Subasa C. Sahoo
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Additional file 1 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1: Endpoints included in the NRCWE hazard assessment studies of the MWCNT panel (A). Specific MWCNT included in each study (B).
Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement
Creators: name: Duan, Xiaobing
name: Ikram Anwar, Muhammad
name: Xu, Zhanxue
name: Ma, Ling
name: Yuan, Guosheng
name: Chen, Yiyi
name: Liu, Xi
name: Xia, Jinyu
name: Zhou, Yuanping
name: Li, Yi-Ping
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development of the HCV replicon and its infectious clones. We and others have previously identified the p7 mutation F772S and the co-presence of NS4A mutations in infectious HCV full-length clones and chimeric recombinants. However, the underlying mechanism of F772S function remains incompletely understood. Here, we investigated the functional role of F772S using an efficient JFH1-based reporter virus with Core-NS2 from genotype 2a strain J6, and we designated J6-p7/JFH1-4A according to the strain origin of the p7 and NS4A sequences. We found that replacing JFH1-4A with J6-4A (wild-type or mutated NS4A) or genotype 2b J8-4A severely attenuated the viability of J6-p7/JFH1-4A. However, passage-recovered viruses that contained J6-p7 all acquired F772S. Introduction of F772S efficiently rescued the viral spread and infectivity titers of J6-p7/J6-4A, which reached the levels of the original J6-p7/JFH1-4A and led to a concomitant increase in RNA replication, assembly and release of viruses with J6-specific p7 and NS4A. These data suggest that an isolate-specific cooperation existed between p7 and NS4A. NS4A exchange- or substitution-mediated viral attenuation was attributed to the RNA sequence, and no p7-NS4A protein interaction was detected. Moreover, we found that F772S-enhanced p7-NS4A cooperation was associated with the enlargement of intracellular lipid droplets. This study therefore provides new insights into the mechanisms of adaptive mutations and facilitates studies on the HCV life cycle and virus–host interaction.
Additional file 2 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 2: Table S2: Tier 1 information extracted from the NRCWE studies for each of the MWCNT panel according to the IATA decision nodes.*Assumed density: 1.7ρg adopted from (Kim et al., 2009).
Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone
Creators: name: Touret, Franck
name: Gilles, Magali
name: Klitting, Raphaelle
name: Aubry, Fabien
name: de Lamballerie, Xavier
name: Nougairède, Antoine
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Zika virus (ZIKV) has recently become dispersed throughout the tropics and sub-tropics, causing epidemics associated with congenital disease and neurological complications. There is currently no commercial vaccine for ZIKV. In this study, we describe the initial development of a chimeric virus containing the prM/E proteins of a ZIKV epidemic strain incorporated into a yellow fever 17-D attenuated backbone. Using the versatile and rapid ISA (Infectious Subgenomic Amplicons) reverse genetics method, we compared different constructs and confirmed the need to modify the cleavage site between the pre-peptide and prM protein. Genotypic characterization of the chimeras indicated that the emergence of compensatory mutations in the E protein was required to restore viral replicative fitness. Using an immunocompromised mouse model, we demonstrated that mice infected with the chimeric virus produced levels of neutralizing antibodies that were close to those observed following infection with ZIKV. Furthermore, pre-immunized mice were protected against viscerotropic and neuroinvasive disease following challenge with a heterologous ZIKV strain. These data provide a sound basis for the future development of this ZIKV vaccine candidate.
Additional file 3 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 3: Table S3: Information gathered from targeted literature search for NM-401 and NRCWE006 to fill data gaps required to progress through the IATA decision nodes.
Exploring Macro-, Micro- and Nanoplastics in the Terrestrial Environment and Uptake by Horticultural Crops
Creators: name: Case, Hannah
name: Wagstaff, Carol
name: Al-Sid-Cheikh, Maya
name: Murphy, Richard
Publisher: name: Zenodo
Year: 2022
Subjects: nanoplastic

description: Plastic pollution is recognised as a growing environmental concern, sparking studies into the fate of plastics in the environment and its degradation to micro- and nanoplastics. To date, research has focused on aquatic environments, whereas studies on the type, distribution, transformation and fate of plastics in the terrestrial environment and the implications for plants are currently in their infancy. Agricultural practices use plastics to improve crop quality and yield, but at the consequence of directly introducing plastics into the soil. This plastic has the potential to alter soil properties and influence growing crops. Data surrounding the impacts and internalisation of plastics by plants was critically evaluated, where a variety of plant stress responses were observed for different plastic types and particle sizes, emphasising the need to track the uptake and distribution of nanoplastics in plant tissue. This uptake has yet to be determined as tracking plastics on the nano scale represents a huge analytical challenge, due to their size, and difficulty detecting carbon-based plastics against a background of carbon-based biological and soil structures. As such, it is the least investigated size of plastic, but could potentially be the most hazardous. This research seeks to examine the presence of plastics in the terrestrial environment and investigate if plastics are able to enter the human food chain through uptake by horticultural crops. This project utilises recent advantages of radiolabelled isotopes for the synthesis of model plastic particles, that can be applied during crop cultivation in environmentally relevant concentrations. This can be measured using highly sensitive instrumentation, including liquid scintillation counting and autoradiography. It is hypothesised that accumulation will occur in the root system, with translocation to aerial parts of a plant. This may be detrimental to plant growth and lead to trophic transfer through the food chain to humans and other animals.
Additional file 4 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 4: Table S4: Summary of inhalation studies assessing the hazard of NRCWE006, NM-401, and NM-403 MWCNT.
Additional file 5 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 5: Fig. S1: NRCWE006, NM-401, NRCWE040 dispersed by ultrasonication in 0.5% BSA/RPMI cell culture media prior to exposure to cells. NRCWE006, NM-401, NRCWE040 and THP-1 cells 24 hours after exposure.
Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding
Creators: name: Lin, Chien-Ju
name: Liu, Ching-Hsuan
name: Wang, Jonathan Y.
name: Lin, Chun-Ching
name: Li, Yi-Fang
name: Richardson, Christopher D.
name: Lin, Liang-Tzung
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Coxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal cases have been reported. Due to the lack of specific medication and vaccines against CVA16, there is currently a need to develop effective antivirals to better control CVA16 infections in epidemic areas. In this study, we identified the tannins chebulagic acid (CHLA) and punicalagin (PUG) as small molecules that can efficiently disrupt the CVA16 infection of human rhabdomyosarcoma cells. Both compounds significantly reduced CVA16 infectivity at micromolar concentrations without apparent cytotoxicity. A mechanistic analysis revealed that the tannins particularly targeted the CVA16 entry phase by inactivating cell-free viral particles and inhibiting viral binding. Further examination by molecular docking analysis pinpointed the targets of the tannins in the fivefold axis canyon region of the CVA16 capsid near the pocket entrance that functions in cell surface receptor binding. We suggest that CHLA and PUG are efficient antagonists of CVA16 entry and could be of value as antiviral candidates or as starting points for developing molecules to treat CVA16 infections.
Inhaltsanzeige zum Stammbuch No. XXXI des Christian Martin Kirchmeyer 1742 / Frejin Elisa Koenig- Warthausen
Creators: name: König-Warthausen, Elise
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1886
Subjects: subject: Warthausen
subject: 090

description: Enthält ein Register zu den Einträgen in das Stammbuch von Christian Martin Kirchmaier
Freundschaftliche| Erinnerungen : Stammbuch
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1792
Subjects: subject: Bayreuth
subject: Kulmbach
subject: 090

description: Enthält 56 Stammbucheinträge in Deutsch, Latein, Englisch, Französisch u.a. von Carl Friedrich Bachelein; Matthias Brömmler; Wolfgang Conradt; Johann Peter Dennler; Friedrich Haube; Jean George Heinritz; Johann Friederich Heintz; Johann Matthias Kösler; Johann Andreas Kösler; Johann Samuel Lenk; Johann Lienhardt; Friz Libermann; Andreas Eugenius Printzing; G. F. E. Reintsch; Margaretha Christiana Schneider; Joh. Georg Schneider; J. G. Schoen; W. K. Senft; Andreas Friedrich Vester; Johann Nicolaus Vester; Friedrich Weise; Johann Wilhelm Wich; Register (unvollständig) enthalten
Additional file 6 of Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Creators: name: Murphy, Fiona
name: Jacobsen, Nicklas Raun
name: Di Ianni, Emilio
name: Johnston, Helinor
name: Braakhuis, Hedwig
name: Peijnenburg, Willie
name: Oomen, Agnes
name: Fernandes, Teresa
name: Stone, Vicki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 6: Fig. S2: Scanning microscopy images of MWCNT panel adapted from (Jackson et al., 2015). Jackson, P., Kling, K., Jensen, K. A., Clausen, P. A., Madsen, A. M., Wallin, H., & Vogel, U. (2015). Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line. Environmental and Molecular Mutagenesis, 56(2), 183–203.
GELMENTLARGA QARSHI SUYUQ EKSTRAKTNI STANDARTLASH
Creators: name: Yunusxojieva, N.E.
name: Khusainova, R.A.
Publisher: name: Zenodo
Year: 2024

description: Bizga ma’lumki, qadim zamonlardan hali zamonaviy tibbiyot mavjud bo‘lmagan vaqtdan boshlab, insonlar o‘zlarining kasalliklarini davolash uchun dorivor o‘simliklardan foydalanib kelishgan. Tibbiyot (dorivor) maqsadlarda ishlatiladigan shifobaxsh o‘simliklar turli xususiyatlarga ega bo‘lgan biologik faol moddalarni (uglevodlar, oqsillar, yog‘lar, glikozidlar, flavonoidlar, efir moylari, alkaloidlar, vitaminlar va hokazo) o‘z ichiga oladi va bizning bu biologik moddalarni o‘rganish, tibbiyotga tadbiq etish farmatsevtika sohasining hozirgi kundagi dolzarb maqsadlaridan bo‘lib kelmoqda.
Stammbuch Spillner
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1789
Subjects: subject: Barnewitz
subject: Berlin
subject: Brandenburg an der Havel
subject: Halle (Saale)
subject: Niemberg
subject: Potsdam
subject: Rathenow
subject: 090

description: Enthält 126 Stammbucheinträge in Deutsch, Latein, Französisch, Griechisch u.a. von I. G. Barowsky; I. F. W. Barth; Friedrich Bothe; F. C. Brandt;W. v. Burgsdorff; J. H. Dedeken; J. G. Gartmann; G.M. Hensler; Gottlob Joachim Hindenburg; J. G. F. Kern; Karl August Köhler; H. Krüger, J.E. Küster; Ferdinand Patzig; F. W. Sack; C. L. Schmidt; M. Schrader; E.F. von Taubenheim; C. Ludwig Spillner (Bruder); J. G. Thiele, J.L. Tornow; Friedrich von Tschierschky (Jurist, Maler); W.H. F. Wackenmoder; Wietersheim