cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Protecting Bangladesh's Ecosystems through Public Interest Litigation
Creators: name: Md. Humaun Kabir
name: Mirza Md. Abu Raihan
Publisher: name: Zenodo
Year: 2024
Subjects: Public interest lawsuits, Bangladeshi legislation, The law of the land, Fundamental freedoms, Activist judges, The highest court in the land, Essential liberties, Environmental problems, Judicial disputes.

description: Abstract: The premise that humans are inherently social gives rise to the relatively recent concept of public interest litigation (PIL) in Bangladeshi law. Disputes involving rights violations or complaints regarding subjects of public interest are the primary focus of public interest litigation (PIL), a branch of constitutional law. On matters of great national importance, regular people can now submit brief legal arguments to the Supreme Court in this way. One powerful tool for judicial activism that upholds human rights and the rule of law is public interest litigation (PIL). It is a fundamental part of the law in Bangladesh. In spite of the challenges, the court is vital in safeguarding basic rights and guaranteeing fair treatment of the state and its citizens in the application of the law. This remains valid, notwithstanding the potential problems. In order to maintain uniformity and provide guidance, the legislative branch seeks the advice of the judiciary. However, the present administration's recruiting practices and the judicial corps' dedication to the standards that regulate their respective professions offer hope for limiting the court's radicalism. Decisions that are rational but nonetheless contentious may be handed down by judges in Bangladesh who are not swayed by political parties. People now expect the courts to deal with environmental issues because the right to life has been broadened to include protection of the environment. To that end, this essay will examine certain cases heard in Bangladeshi courts that illustrate the role of public-interest litigation in bringing about justice.
Puppy parties and beyond: the role of early age socialization practices on adult dog behavior
Creators: name: Howell, Tiffani
name: King, T
name: Bennett, Pauleen
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3009
subject: Veterinary sciences
subject: FOS: Veterinary sciences

description: The most common role of a domestic dog in the developed world currently is that of companion. Puppy socialization practices play a large role in the development of well-adjusted adult dogs that display few undesirable behaviors, and which can establish a positive, lifelong relationship with their owner. Age-appropriate socialization practices should begin within a few days of birth, and should extend well into adulthood. These practices should aim to provide exposure to many of the types of experiences, people, and objects that the dog is likely to encounter over the course of its life, in a controlled and pleasant way. Dogs that are appropriately socialized as puppies are less likely to exhibit behavioral problems as adults, including aggression and fearfulness. They are more likely to engage in positive social behaviors with humans, and can learn how to play games with humans better than dogs without proper socialization. However, the evidence in support of puppy socialization classes is less clear. There is some evidence that puppy classes positively impact adult behavior, but other studies show no clear benefit. Since socialization should begin early in a puppy's life, it is the responsibility of the breeder and the owner. Breeders can ensure that puppies are exposed to age-appropriate experiences while in the litter, and owners must ensure that the dog continues to have varied experiences throughout its life. Veterinarians are also an important part of this process, and are heavily relied upon by owners to provide information about health and behavior. Since veterinarians often see puppies during vaccinations, owners can be educated about proper socialization practices at those visits. Future research should aim to determine the minimum amounts of socialization required for a puppy, and whether there is a maximum amount, beyond which there is no benefit, or even a disadvantage.
Mouse models for gastric cancer: matching models to biological questions
Creators: name: Poh, Ashleigh
name: O'Donoghue, Robert JJ
name: Ernst, Matthias
name: Putoczki, TL
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Gastric cancer is the third leading cause of cancer-related mortality worldwide. This is in part due to the asymptomatic nature of the disease, which often results in late-stage diagnosis, at which point there are limited treatment options. Even when treated successfully, gastric cancer patients have a high risk of tumor recurrence and acquired drug resistance. It is vital to gain a better understanding of the molecular mechanisms underlying gastric cancer pathogenesis to facilitate the design of new-targeted therapies that may improve patient survival. A number of chemically and genetically engineered mouse models of gastric cancer have provided significant insight into the contribution of genetic and environmental factors to disease onset and progression. This review outlines the strengths and limitations of current mouse models of gastric cancer and their relevance to the pre-clinical development of new therapeutics.
title: Zentral finanzieren, gemeinsam steuern, einzeln profitieren: Zentralisierung als Weg zur digitalen Verwaltung
title: Die Verwaltung grundlegend mit Government as a Platform ändern
titleType: Subtitle
Creators: name: Mahendran, Thilak
Publisher: name: Agora Digitale Transformation gGmbH
Year: 2024

description: Die digitale Transformation der öffentlichen Verwaltung in Deutschland steht an einem kritischen Wendepunkt. Dieses Hypothesenpapier wirft einen Blick auf den Status quo und entwirft zugleich eine Vision für die Zukunft. Im Zentrum der Betrachtung steht ein Konzept mit dem Potenzial, die Verwaltungslandschaft grundlegend zu verändern: „Government as a Platform“ (GaaP).

Basierend auf aktuellen Forschungsergebnissen, Praxisbeispielen und Expert:innengesprächen aus Verwaltung, Wissenschaft und Wirtschaft, wurden acht Kernthesen entwickelt:

Proaktivität: Die Verwaltung der Zukunft muss proaktiv handeln, statt nur zu reagieren.

Paradigmenwechsel: Das Onlinezugangsgesetz (OZG) greift zu kurz - ein Paradigmenwechsel ist notwendig.

Abstraktion: GaaP ist vielversprechend, aber noch zu abstrakt für die praktische Umsetzung.

Lücken: Trotz erster Fortschritte fehlen zentrale Bausteine für eine echte digitale Transformation.

Potenzial: Das „Einer für Alle“-Prinzip (EfA) hat Potenzial, aber auch große Schwachstellen.

Heterogenität: Uneinheitliche IT-Basiskomponenten bremsen die Effizienz.

Zentralisierung: Eine zentrale Steuerung der IT-Basiskomponenten ist der Schlüssel zum Erfolg.

Verfassungsänderung: Für eine effektive zentrale IT-Steuerung ist eine Anpassung des Grundgesetzes erforderlich.

Das Papier plädiert für einen mutigen Schritt: Durch gezielte Zentralisierung sollen die Dezentralität und Effizienz in der öffentlichen Verwaltung gestärkt werden. Dieser scheinbare Widerspruch könnte sich als Lösung für viele aktuelle Herausforderungen erweisen. Die Analyse zeigt auf, warum einheitliche IT-Basiskomponenten so entscheidend sind und skizziert konkrete Schritte, um die digitale Transformation der Verwaltung voranzutreiben. Ziel ist es, nicht nur zu analysieren, sondern auch praktikable Lösungswege aufzuzeigen – für eine Verwaltung, die den Anforderungen des 21. Jahrhunderts gerecht wird.
title: Letter: Albertis S. Harrison, Jr. to C. Harrison Mann, Jr., July 27, 1957
Creators: name: Harrison, Albertis S. (Albertis Sydney), 1907-
name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Segregation
subject: Integration
subject: Schools
subject: Massive Resistance
subject: Political campaigns

description: Letter: typescript signed, 11" x 8.5" (29.7 cm x 21.6 cm)
description: Letter from Albertis S. Harrison, Jr., Virginia Commonwealth attorney for Brunswick County, to C. Harrison Mann, Jr. regarding Virginia school integration, Massive Resistance, and its impact on that year's campaigning. C. Harrison Mann, Jr. Collection 3.06
Differentially Expressed Genes in Endometrium and Corpus Luteum of Holstein Cows Selected for High and Low Fertility Are Enriched for Sequence Variants Associated with Fertility
Creators: name: Moore, SG
name: Pryce, Jennie
name: Hayes, BJ
name: Chamberlain, Amanda
name: Kemper, KE
name: Berry, DP
name: McCabe, M
name: Cormican, P
name: Lonergan, P
name: Fair, T
name: Butler, ST
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3003
subject: Animal production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3105
subject: Genetics
classificationCode: 3109
subject: Zoology
classificationCode: 3215
subject: Reproductive medicine

description: Despite the importance of fertility in humans and livestock, there has been little success dissecting the genetic basis of fertility. Our hypothesis was that genes differentially expressed in the endometrium and corpus luteum on Day 13 of the estrous cycle between cows with either good or poor genetic merit for fertility would be enriched for genetic variants associated with fertility. We combined a unique genetic model of fertility (cattle that have been selected for high and low fertility and show substantial difference in fertility) with gene expression data from these cattle and genome-wide association study (GWAS) results in ;20 000 cattle to identify quantitative trait loci (QTL) regions and sequence variants associated with genetic variation in fertility. Two hundred and forty-five QTL regions and 17 sequence variants associated primarily with prostaglandin F2alpha, steroidogenesis, mRNA processing, energy status, and immune-related processes were identified. Ninety-three of the QTL regions were validated by two independent GWAS, with signals for fertility detected primarily on chromosomes 18, 5, 7, 8, and 29. Plausible causative mutations were identified, including one missense variant significantly associated with fertility and predicted to affect the protein function of EIF4EBP3. The results of this study enhance our understanding of 1) the contribution of the endometrium and corpus luteum transcriptome to phenotypic fertility differences and 2) the genetic architecture of fertility in dairy cattle. Including these variants in predictions of genomic breeding values may improve the rate of genetic gain for this critical trait.
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.
Creators: name: Conduit, Sarah E
name: Pearce, Wayne
name: Bhamra, Amandeep
name: Bilanges, Benoit
name: Bozal-Basterra, Laura
name: Foukas, Lazaros C
name: Cobbaut, Mathias
name: Castillo, Sandra D
name: Danesh, Mohammad Amin
name: Adil, Mahreen
name: Carracedo, Arkaitz
name: Graupera, Mariona
name: McDonald, Neil Q
name: Parker, Peter J
name: Cutillas, Pedro R
name: Surinova, Silvia
name: Vanhaesebroeck, Bart
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Signalling & Oncogenes
subject: Signalling & Oncogenes
classificationCode: Chemical Biology & High Throughput
subject: Chemical Biology & High Throughput
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Structural Biology & Biophysics
subject: Structural Biology & Biophysics
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Cell Cycle & Chromosomes
subject: Cell Cycle & Chromosomes

description: Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly. Genetic PI3Kα-hyperactivation, as observed in PIK3CA-related overgrowth spectrum (PROS) and cancer, induced a ciliopathy-like phenotype during mouse development. Mechanistically, PI3Kα and PI3Kβ produce the PIP3 lipid at the cilia transition zone upon disassembly stimulation. PI3Kα activation initiates cilia disassembly through a kinase signalling axis via the PDK1/PKCι kinases, the CEP170 centrosomal protein and the KIF2A microtubule-depolymerising kinesin. Our data suggest diseases caused by PI3Kα-activation may be considered 'Disorders with Ciliary Contributions', a recently-defined subset of ciliopathies in which some, but not all, of the clinical manifestations result from cilia dysfunction.
Mismatch in epitope specificities between IFNy inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Creators: name: Woods, K
name: Knights, AJ
name: Anaka, M
name: Schittenhelm, RB
name: Purcell, AW
name: Behren, Andreas
name: Cebon, Jonathan
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Background: A current focus in cancer treatment is to broaden responses to immunotherapy. One reason these therapies may prove inadequate is that T lymphocytes fail to recognize the tumor due to differences in immunogenic epitopes presented by the cancer cells under inflammatory or non-inflammatory conditions. The antigen processing machinery of the cell, the proteasome, cleaves proteins into peptide epitopes for presentation on MHC complexes. Immunoproteasomes in inflammatory melanomas, and in antigen presenting cells of the immune system, are enzymatically different to standard proteasomes expressed by tumors with no inflammation. This corresponds to alterations in protein cleavage between proteasome subtypes, and a disparate repertoire of MHC-presented epitopes. Methods: We assessed steady state and IFNγ-induced immunoproteasome expression in melanoma cells. Using epitope specific T-lymphocyte clones, we studied processing and presentation of three NY-ESO-1 HLA-Cw3 restricted epitopes by melanoma cell lines. Our experimental model allowed comparison of the processing of three distinct epitopes from a single antigen presented on the same HLA complex. We further investigated processing of these epitopes by direct inhibition, or siRNA mediated knockdown, of the immunoproteasome catalytic subunit LMP7. Results: Our data demonstrated a profound difference in the way in which immunogenic T-lymphocyte epitopes are presented by melanoma cells under IFNγ inflammatory versus non-inflammatory conditions. These alterations led to significant changes in the ability of T-lymphocytes to recognize and target melanoma cells. Conclusions: Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation
Creators: name: Carrasco-Ramirez, P
name: Greening, David
name: Andres, G
name: Gopal, SK
name: Martin-Villar, E
name: Renart, J
name: Simpson, Richard
name: Quintanilla, M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Podoplanin (PDPN) is a transmembrane glycoprotein that plays crucial roles in embryonic development, the immune response, and malignant progression. Here, we report that cells ectopically or endogenously expressing PDPN release extracellular vesicles (EVs) that contain PDPN mRNA and protein. PDPN incorporates into membrane shed microvesicles (MVs) and endosomal-derived exosomes (EXOs), where it was found to colocalize with the canonical EV marker CD63 by immunoelectron microscopy. We have previously found that expression of PDPN in MDCK cells induces an epithelial-mesenchymal transition (EMT). Proteomic profiling of MDCK-PDPN cells compared to control cells shows that PDPN-induced EMT is associated with upregulation of oncogenic proteins and diminished expression of tumor suppressors. Proteomic analysis of exosomes reveals that MDCK-PDPN EXOs were enriched in protein cargos involved in cell adhesion, cytoskeletal remodeling, signal transduction and, importantly, intracellular trafficking and EV biogenesis. Indeed, expression of PDPN in MDCK cells stimulated both EXO and MV production, while knockdown of endogenous PDPN in human HN5 squamous carcinoma cells reduced EXO production and inhibited tumorigenesis. EXOs released from MDCK-PDPN and control cells both stimulated in vitro angiogenesis, but only EXOs containing PDPN were shown to promote lymphatic vessel formation. This effect was mediated by PDPN on the surface of EXOs, as demonstrated by a neutralizing specific monoclonal antibody. These results contribute to our understanding of PDPN-induced EMT in association to tumor progression, and suggest an important role for PDPN in EV biogenesis and/or release and for PDPN-EXOs in modulating lymphangiogenesis.
A peptidomic approach to discover the potential biomolecular signatures discriminating in-bag dry- and wet-aged lamb
Creators: name: Zhang, Renyu
name: Maes, Evelyne
name: Hefer, Charles
name: Noble, Alasdair
name: Thomas, Ancy
name: Yoo, Michelle
name: Farouk, Mustafa
name: Realini Cujo, Carolina
name: Deb Choudhury, Santanu
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3006
subject: Food sciences

description: The study assessed the peptidomic profile of in-bag dry-aged (2 °C, RH 75 %, 0.5 m.s−1, n = 30) and wet-aged (-1.5 °C, n = 30) lamb with high and low levels of lipid oxidation. A total of 1056 low molecular weight peptides (< 10 kDa) were identified in aged lamb samples, using LC-MS/MS and label free quantification (data are available via ProteomeXchange with identifier PXD047738). Partial Least Squares – Discriminant analysis highlighted that all discriminating peptides in dry-aged lamb were from titin, whereas discriminating peptides in the wet-aged samples were predominantly from nebulin, myotilin, collagen type IV, LIM domain binding 3, and heat shock protein family B. Comparison of peptides from aged lamb meat with high- and low-levels of lipid oxidation showed that most discriminatory peptides within an ageing method are derived from oxidatively modified peptides from creatine kinase. These peptides could thus potentially be used as signature biomolecules to discriminate ageing techniques and indicate lipid oxidation levels.
MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing
Creators: name: Wong, NC
name: Pope, BJ
name: Candiloro, IL
name: Korbie, D
name: Trau, M
name: Wong, Stephen Q
name: Mikeska, Thomas
name: Zhang, X
name: Pitman, M
name: Eggers, S
name: Doyle, Stephen R
name: Dobrovic, Alexander
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3105
subject: Genetics
classificationCode: 46
subject: Information and computing sciences
classificationCode: 49
subject: Mathematical sciences

description: Background: DNA methylation at a gene promoter region has the potential to regulate gene transcription. Patterns of methylation over multiple CpG sites in a region are often complex and cell type specific, with the region showing multiple allelic patterns in a sample. This complexity is commonly obscured when DNA methylation data is summarised as an average percentage value for each CpG site (or aggregated across CpG sites). True representation of methylation patterns can only be fully characterised by clonal analysis. Deep sequencing provides the ability to investigate clonal DNA methylation patterns in unprecedented detail and scale, enabling the proper characterisation of the heterogeneity of methylation patterns. However, the sheer amount and complexity of sequencing data requires new synoptic approaches to visualise the distribution of allelic patterns. Results: We have developed a new analysis and visualisation software tool "Methpat", that extracts and displays clonal DNA methylation patterns from massively parallel sequencing data aligned using Bismark. Methpat was used to analyse multiplex bisulfite amplicon sequencing on a range of CpG island targets across a panel of human cell lines and primary tissues. Methpat was able to represent the clonal diversity of epialleles analysed at specific gene promoter regions. We also used Methpat to describe epiallelic DNA methylation within the mitochondrial genome. Conclusions: Methpat can summarise and visualise epiallelic DNA methylation results from targeted amplicon, massively parallel sequencing of bisulfite converted DNA in a compact and interpretable format. Unlike currently available tools, Methpat can visualise the diversity of epiallelic DNA methylation patterns in a sample.
PIFSC implementation plan (2016).
Creators: name: Seki, Michael P.
name: Howell, Evan A.
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Pacific Islands Fisheries Science Center
Year: 2016
Subjects: subject: Pacific Islands Fisheries Science Center (U.S.)--Research--Planning.

description: This Implementation Plan (Plan) describes the process by the Pacific Islands Fisheries Science Center (PIFSC) to plan and prioritize research activities, allocate resources, and conduct reviews of scientific work products. This Plan is a complement to the PIFSC Science Plan , which was developed in 2013, and provides the overall framework and strategic vision for science planning. Unlike the Science Plan, this Plan is focused on the individual processes that make up the annual cycle of plan, prioritize, allocate, and review.
Deep Roots for Aboriginal Australian Y Chromosomes
Creators: name: Bergstroem, A
name: Nagle, Nano
name: Chen, Yuan
name: McCarthy, Shane
name: Pollard, MO
name: Ayub, Qasim
name: Wilcox, Stephen
name: Wilcox, Leah
name: van Oorschot, Roland
name: McAllister, P
name: Williams, Leslie
name: Xue, Yali
name: Mitchell, Robert
name: Tyler-Smith, Chris
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3105
subject: Genetics
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Australia was one of the earliest regions outside Africa to be colonized by fully modern humans, with archaeological evidence for human presence by 47,000 years ago (47 kya) widely accepted [1, 2]. However, the extent of subsequent human entry before the European colonial age is less clear. The dingo reached Australia about 4 kya, indirectly implying human contact, which some have linked to changes in language and stone tool technology to suggest substantial cultural changes at the same time [3]. Genetic data of two kinds have been proposed to support gene flow from the Indian subcontinent to Australia at this time, as well: first, signs of South Asian admixture in Aboriginal Australian genomes have been reported on the basis of genome-wide SNP data [4]; and second, a Y chromosome lineage designated haplogroup C-, present in both India and Australia, was estimated to have a most recent common ancestor around 5 kya and to have entered Australia from India [5]. Here, we sequence 13 Aboriginal Australian Y chromosomes to re-investigate their divergence times from Y chromosomes in other continents, including a comparison of Aboriginal Australian and South Asian haplogroup C chromosomes. We find divergence times dating back to ∼50 kya, thus excluding the Y chromosome as providing evidence for recent gene flow from India into Australia.
Deep Roots for Aboriginal Australian Y Chromosomes
Creators: name: Bergstroem, A
name: Nagle, Nano
name: Chen, Yuan
name: McCarthy, Shane
name: Pollard, MO
name: Ayub, Qasim
name: Wilcox, Stephen
name: Wilcox, Leah
name: van Oorschot, Roland
name: McAllister, P
name: Williams, Leslie
name: Xue, Yali
name: Mitchell, R John
name: Tyler-Smith, Chris
Publisher: name: La Trobe
Year: 2023

description: Australia was one of the earliest regions outside Africa to be colonized by fully modern humans, with archaeological evidence for human presence by 47,000 years ago (47 kya) widely accepted [1, 2]. However, the extent of subsequent human entry before the European colonial age is less clear. The dingo reached Australia about 4 kya, indirectly implying human contact, which some have linked to changes in language and stone tool technology to suggest substantial cultural changes at the same time [3]. Genetic data of two kinds have been proposed to support gene flow from the Indian subcontinent to Australia at this time, as well: first, signs of South Asian admixture in Aboriginal Australian genomes have been reported on the basis of genome-wide SNP data [4]; and second, a Y chromosome lineage designated haplogroup C-, present in both India and Australia, was estimated to have a most recent common ancestor around 5 kya and to have entered Australia from India [5]. Here, we sequence 13 Aboriginal Australian Y chromosomes to re-investigate their divergence times from Y chromosomes in other continents, including a comparison of Aboriginal Australian and South Asian haplogroup C chromosomes. We find divergence times dating back to ∼50 kya, thus excluding the Y chromosome as providing evidence for recent gene flow from India into Australia.
Beyond Neglect: Preliminary Evidence of Retrospective Time Estimation Abnormalities in Non-Neglect Stroke and Transient Ischemic Attack Patients
Creators: name: Low, Essie
name: Crewther, Sheila
name: Perre, Diana
name: Ong, Ben
name: Laycock, Robin
name: Tu, Hans
name: Wijeratne, Kulasekara
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5202
subject: Biological psychology

description: Perception of the passage of time is essential for safe planning and navigation of everyday activities. Findings from the literature have demonstrated a gross underestimation of time interval in righthemisphere damaged neglect patients, but not in non-neglect unilaterally-damaged patients, compared to controls. This study aimed to investigate retrospective estimation of the duration of a target detection task over two occasions, in 30 stroke patients (12 left-side stroke 15 right-side stroke, and 3 right-side stroke with neglect) and 10 transient ischemic attack patients, relative to 31 agematched controls. Performances on visual short-term and working memory tasks were also examined to investigate the associations between timing abilities with residual cognitive functioning. Initial results revealed evidence of perceptual time underestimation, not just in neglect patients, but also in non-neglect unilaterally-damaged stroke patients and transient ischemic attack patients. Three months later, underestimation of time persisted only in left-side stroke and right-side stroke with neglect patients, who also demonstrated reduced short-term and working memory abilities. Findings from this study suggest a predictive role of residual cognitive impairments in determining the prognosis of perceptual timing abnormalities.
Sexuality, sexual health and older people: A systematic review of research on the knowledge and attitudes of health professionals
Creators: name: Haesler, Emily
name: Bauer, Michael
name: Fetherstonhaugh, Deirdre
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3901
subject: Curriculum and pedagogy
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 420301
subject: Aged health care
classificationCode: 4204
subject: Midwifery
classificationCode: 4205
subject: Nursing

description: Objectives: Sexuality remains important to older people and should be recognised as an important part of their overall care. However, this appears to be poorly understood and addressed by many healthcare professionals. This systematic review reports on knowledge and attitudes of health professionals towards sexuality and sexual health of older people, including factors that impact knowledge and perceptions. Review methods and data sources: The review, conducted using Joanna Briggs Institute methods, included 23 studies of varied methodology published between January 2004 and January 2015. Results: Findings indicated that healthcare professionals often consider older people's sexuality as outside their scope of practice and there is lack of knowledge and confidence in this area. Cultural norms and taboos, length of time spent working with older people, familiarity with the older person, previous training and degree of exposure to people who are not heterosexual were all identified as factors that impact knowledge and attitude. Conclusions: Better role modelling and education are needed to improve knowledge and attitudes toward later life sexuality.
The Carbon Footprint of WEEE (Waste Electronic and Electrical Equipment) in the UK – a case study based on the UK’s largest WEEE producer compliance scheme
Creators: name: Bond, Matthew
Publisher: name: Lancaster University
Year: 2022
Subjects: UK WEEE
E-waste recycling
LCA
WEEE Carbon Footprint
Carbon Footprint Optimisation
Waste management LCA

description: 500,000 tonnes of waste electrical and electronic equipment (WEEE) is collected and treated in the authorised WEEE system in the UK annually. Greenhouse gas emissions result from the transportation and treatment processes, but emissions reductions occur elsewhere in the economy when secondary materials, reused EEE and recovered electricity substitute virgin materials. Here we investigate the carbon footprint of the authorised WEEE system in the UK, utilising a combined material flow analysis (MFA) and life cycle assessment (LCA). The potential for improvements in the carbon footprint are investigated through optimisation of logistics by solving a Vehicle Routing Problem with the objective of minimising carbon footprint. Detailed primary data was obtained from a producer compliance scheme and the collection and pre- treatment operators, yielding highly specific emissions and material flow data across these stages. Data covering the recycling, incineration and landfill stages was sourced from the Ecoinvent 3.7 database. The LCA results show a net carbon footprint benefit for the collection and treatment across all WEEE streams. The average carbon footprint per tonne of WEEE was -2.01tCO2eq., consisting of 0.903tCO2eq. of gross emissions and -2.92tCO2eq. of avoided emissions. The gross emissions are mainly from recycling and energy-from-waste, and the avoided emissions from the substitution of 0.748t of virgin material with recycled material. Furthermore, optimisation of AATF allocation achieved a further improvement of 0.22tCO2eq. per tonne of WEEE by increasing use of AATFs with higher recovery rates. Specific findings include the large range in total emissions when WEEE is sent to different pre- treatment plants, and the finding that energy-from-waste is less beneficial than landfill from a carbon footprint perspective. Implications include informing decision making at the industry and policy level to improve the carbon footprint of the WEEE system and increasing public awareness of the benefit of correct WEEE disposal.
The Protein Composition of Bovine Milk from Once-a-Day and Twice-a-Day Milking Production Systems in New Zealand
Creators: name: van der Zeijden, Marit
name: Ellis, Ashling
name: Lopez-Villalobos, Nicolas
name: Li, Siqi
name: Roy, Nicole
name: McNabb, Warren
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences

description: An increasing number of dairy farmers in New Zealand (NZ) have adopted a once-a-day (OAD) milking production system, and little is known about the impact of this production system on milk protein composition. The objective of this study was to evaluate the effect of OAD milking on the protein composition in milk from individual cows. Milk was sampled in early, mid-, and late lactation from cows kept at Massey University farms Dairy No. 1 (OAD milking) and Dairy No. 4 (TAD milking) in Palmerston North, NZ. The yields of total milk and milk solids, the proximate composition, and the protein composition were determined. Results showed that OAD milking yielded less milk and milk solids than TAD milking. However, no significant differences in protein, fat, and lactose contents were found. While the proportions of total casein (CN), total whey proteins, αs1-CN, β-CN, and β-lactoglobulin were not affected by the milking frequency, milk from a OAD milking system contained higher proportions of αs2-CN and κ-CN and lower proportions of α-lactalbumin. These proteins also changed differently throughout the milking season in a OAD milking system than in a TAD milking system. These changes in the protein composition of the milk observed in a OAD milking system could have implications for its processing properties and product quality.
Changing definitions altered multimorbidity prevalence, but not burden associations, in a musculoskeletal population
Creators: name: Lowe, Dianne
name: Taylor, Michael
name: Hill, Sophie
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4202
subject: Epidemiology
classificationCode: 4206
subject: Public health

description: Objectives: The inclusion of musculoskeletal conditions within multimorbidity research is inconsistent, and working-age populations are largely ignored. We aimed to: (1) estimate multimorbidity prevalence among working-age individuals with a range of musculoskeletal conditions; and (2) better understand the implications of decisions about the number and range of conditions constituting multimorbidity on the strength of associations between multimorbidity and burden (e.g., health status and health care utilization). Study Design and Setting: Using data from the Australian National Health Survey 2007–08, the associations between burden measures and three ways of operationalizing multimorbidity (survey, policy, and research based) within the working-age (18–64 years) musculoskeletal population were estimated using multiple logistic regression (age and gender adjusted). Results: Depending on definition, from 20.2% to 75.4% of working-age individuals with musculoskeletal conditions have multimorbidity. Irrespective of definition, multimorbidity was associated with increased likelihood of subjective health burden, pain or musculoskeletal medicines use, nonmusculoskeletal specialist and pharmacist (advice only) consultations, and reduced likelihood of not consulting health professionals. A group with intermediate health outcomes was considered multimorbid by some, but not all definitions. With the restrictive policy and research multimorbidity definitions, this intermediate group is included within the reference population (i.e., are considered nonmultimorbid). This worsens the reference group's apparent health status thereby leveling the comparative burden between those with and without multimorbidity. Consequently, dichotomous cut points lead to similar associations with burden measures despite the increasingly restrictive multimorbidity definitions used. Conclusions: All multimorbidity definitions were associated with burden among the working-age musculoskeletal population. However, dichotomous cut points obscure the gradient of increased burden associated with restrictive definitions.
title: Unbinding of Abeta peptides from amyloid fibrils: explicit solvent molecular dynamics study
Creators: name: Mishra, Pamela Haradhan
Publisher: name: George Mason University
Year: 2009
Subjects: subject: Amyloid fibrils
subject: Alzheimers
subject: Explicit solvent model
subject: Unbinding Abeta peptides

description: We used all-atom molecular dynamics to investigate the unbinding of Alzheimer’s Abeta peptides from amyloid fibrils. The peptide unbinding is driven by temperature-induced structural fluctuations and is thought of as an elementary step in the molecular recycling occurring between fibrillized and soluble Abeta species. Several conclusions can be drawn from our data. Early unbinding stages can be observed on the 100 ns timescale, although complete dissociation is likely to occur on much longer timescale. The unbinding pathway starts with fraying of β-strands from Abeta fibril. We predict that most peptide-fibril interactions will be initially lost by the N-terminal of Abeta peptide. This unbinding scenario can be modified by the specific location of dissociating peptide on the fibril edge. Our simulations provide new molecular details on the process of amyloidogenesis linked to Alzheimer’s disease.
Deut ganen ta, plac' hig yaouank
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Supplementary document for Angle-insensitive topological interface states in hybrid one-dimensional photonic crystal heterostructures containing all-dielectric metamaterials - 6418435.pdf
Creators: name: Wu, Feng
name: Li, Hong-Ju
name: Hu, Shi
name: Chen, Ying
name: Long, Yang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: In this supplementary material, we give a comparison of angle-dependent property between the designed photonic bandgaps and the conventional photonic bandgaps and a robustness analysis of angle-insensitive property of topological interface state.
Anthrenus (Anthrenus) latefasciatus Reitter 1892
Creators: name: Háva, Jiří
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dermestidae
Anthrenus
Anthrenus latefasciatus

description: Anthrenus (Anthrenus) latefasciatus Reitter, 1892
Material examined: Material examined: Kyrgyzstan, Chuy Region, Nur env. (near Kemin), Chu River, 7- 8.6.2019, lgt. Jan Pelikán / 42°47´10.141´´N 75°45´11.338´´ E, pastures, riverside, beating vegetation, 4 spec., (JPPC).
Remarks. This species was recently recorded from Kyrgyzstan by Háva & Kadej (2009) and Kadej (2010).
description: Published as part of Háva, Jiří, 2022, A contribution to knowledge of the Dermestidae (Coleoptera) fauna of Kyrgyzstan, pp. 1-3 in Faunitaxys (London, England) (London, England) 10 (32) on page 1, DOI: 10.57800/faunitaxys-10(32), http://zenodo.org/record/15365662
Human trafficking: factors that influence willingness to combat the issue
Creators: name: Honeyman, Katherine
name: Stukas, Arthur
name: Marques, Mathew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2016 Wiley Periodicals, Inc Human trafficking involves severe violations of human rights and social action is required to combat it. Past research has identified emotional reactions to victims of trafficking, as well as the perceived cost and efficacy of actions, as significant predictors of willingness to get involved. We surveyed 216 Australians (70% female) to assess their perceptions of sex and labor trafficking and actions to reduce them. Results demonstrated that women reported greater personal distress (but not empathy) for victims than men, which was associated with greater willingness to take action. Women also perceived available actions to be more efficacious than men, which predicted willingness, while perceived cost of actions did not. Implications for promoting social action to reduce human trafficking are discussed.
title: Resolution and minutes: George Mason College Advisory Board supporting separation from University of Virginia, January 24, 1972
Creators: name: Arundel, Arthur
name: Bernhardt, Sandy
Publisher: name: George Mason College Advisory Board
Year: 1972
Subjects: subject: George Mason College
subject: Separation

description: Resolution: 2 pg, typescript 8.5" X 11" (29.7 cm x 21.6 cm) Minutes: 5 pg, Typescript and hand-signed 8.5" X 11" (29.7 cm x 21.6 cm)
description: Resolution supporting independent status for George Mason College as drafted by the George Mason College Advisory Board. George Mason University Archives, Papers of the Presidents, Box 7, Folder 1. Meeting minutes of the January 24, 1972 meeting of the George Mason Advisory Board as recorded by Sandy Bernhardt. George Mason University Archives, Papers of the Presidents, Box 7, Folder 1.
title: Printing Plate: Washington Post, March 27, 2006
Creators: name: Washington Post
Publisher: name: George Mason University
Year: 2006
Subjects: subject: George Mason University
subject: Basketball
subject: National Collegiate Athletic Association (NCAA)

description: Printing Plate: aluminum, 12.5" x 23" (31.8 cm x 58.4 cm)
description: Printing Plate from the March 27, 2006 edition of The Washington Post. This edition ran the morning after George Mason University defeated the University of Connecticut to advance into the Final Four. 2005-06 Men's Basketball Season and Tournament Run Collection
Extracellular vesicle isolation and characterization: toward clinical application
Creators: name: Xu, Rong
name: Greening, David
name: H-J Zhu
name: N Takahashi
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Two broad categories of extracellular vesicles (EVs), exosomes and shed microvesicles (sMVs), which differ in size distribution as well as protein and RNA profiles, have been described. EVs are known to play key roles in cell-cell communication, acting proximally as well as systemically. This Review discusses the nature of EV subtypes, strategies for isolating EVs from both cell-culture media and body fluids, and procedures for quantifying EVs. We also discuss proteins selectively enriched in exosomes and sMVs that have the potential for use as markers to discriminate between EV subtypes, as well as various applications of EVs in clinical diagnosis.
Protein crystal screening and characterization for serial femtosecond nanocrystallography
Creators: name: Darmanin, Connie
name: Strachan, J
name: Adda, Christopher
name: Ve, T
name: Kobe, B
name: Abbey, Brian
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: The recent development of X-ray free electron lasers (XFELs) has spurred the development of serial femtosecond nanocrystallography (SFX) which, for the first time, is enabling structure retrieval from sub-micron protein crystals. Although there are already a growing number of structures published using SFX, the technology is still very new and presents a number of unique challenges as well as opportunities for structural biologists. One of the biggest barriers to the success of SFX experiments is the preparation and selection of suitable protein crystal samples. Here we outline a protocol for preparing and screening for suitable XFEL targets.
Anthrenus (Ranthenus) kryzhanovskii Sokolov 1979
Creators: name: Háva, Jiří
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dermestidae
Anthrenus
Anthrenus kryzhanovskii

description: Anthrenus (Ranthenus) kryzhanovskii Sokolov, 1979
Material examined. – Kyrgyzstan, Chuy Region, Nur env. (near Kemin), Chu River, 7- 8.6.2019, lgt. Jan Pelikán / 42°47´10.141´´N 75°45´11.338´´ E, pastures, riverside, beating vegetation, 10 spec., (8 JPPC, 2 JHAC).
Remarks. – This species was recently recorded from Kyrgyzstan by Háva & Kadej (2009) and Kadej (2010).
description: Published as part of Háva, Jiří, 2022, A contribution to knowledge of the Dermestidae (Coleoptera) fauna of Kyrgyzstan, pp. 1-3 in Faunitaxys (London, England) (London, England) 10 (32) on page 1, DOI: 10.57800/faunitaxys-10(32), http://zenodo.org/record/15365662
title: Post-Soviet Russian Foreign Policy Toward The Middle East
Creators: name: Katz, Mark N.
Publisher: name: Charles Schlacks Jr.
Year: 1996
Subjects: subject: Russia
subject: Middle East
subject: International relations
subject: Foreign Policy

description: http://www.schlacks.com/
description: Since the breakup of the USSR in 1991, there has been significant change in Moscow's Middle East policy. During much of the Cold War, Moscow sought to project Soviet influence throughout even the far off Arab region of the Middle East. In the post-Cold War era, though, Russian foreign policy has focused on that part of the Middle East closest to the former USSR-the Northern Tier. This article will examine the major aspects of post-Cold War Russian foreign policy toward the Middle East in order to identify Moscow's multiple goals in the region and discuss Moscow's capacIty for achieving them.
Markedly enhanced analysis of mass spectrometry images using weakly supervised machine learning
Creators: name: Gardner, Wil
name: Winkler, David
name: Bamford, Sarah
name: Muir, Benjamin
name: Pigram, Paul
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 4611
subject: Machine learning
classificationCode: 3401
subject: Analytical chemistry

description: Supervised and unsupervised machine learning algorithms are routinely applied to time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging data and, more broadly, to mass spectrometry imaging (MSI). These algorithms have accelerated large-scale, single-pixel analysis, classification, and regression. However, there is relatively little research on methods suited for so-called weakly supervised problems, where ground-truth class labels exist at the image level, but not at the individual pixel level. Unsupervised learning methods are usually applied to these problems. However, these methods cannot make use of available labels. Here a novel method specifically designed for weakly supervised MSI data is presented. A dual-stream multiple instance learning (MIL) approach is adapted from computational pathology that reveals the spatial-spectral characteristics distinguishing different classes of MSI images. The method uses an information entropy-regularized attention mechanism to identify characteristic class pixels that are then used to extract characteristic mass spectra. This work provides a proof-of-concept exemplification using printed ink samples imaged by ToF-SIMS. A second application-oriented study is also presented, focusing on the analysis of a mixed powder sample type. Results demonstrate the potential of the MIL method for broader application in MSI, with implications for understanding subtle spatial-spectral characteristics in various applications and contexts.
Isolation of cardiomyocytes and cardiofibroblasts for ex vivo analysis
Creators: name: Mbogo, George
name: Nedeva, Christina
name: Puthalakath, Hamsa
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3404
subject: Medicinal and biomolecular chemistry

description: No description supplied