cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(401871) Margaret Matthew Whitson Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers
Creators: name: Wongvipat, John
name: Cai, Ling
name: Arora, Vivek K.
name: Shah, Neel P.
name: Zheng, Deyou
name: Jasin, Maria
name: Zelefsky, Michael J.
name: Chaudhuri, Jayanta
name: Powell, Simon N.
name: Sawyers, Charles L.
name: Polkinghorn, William R.
name: Watson, Philip A.
name: Iaquinta, Phillip J.
name: Yen, Wei Feng
name: Gopalan, Anuradha
name: Kass, Elizabeth M.
name: Parker, Joel S.
name: Hieronymus, Haley
name: Spratt, Daniel E.
name: Carver, Brett S.
name: Scardino, Peter T.
name: Chen, Yu
name: Goglia, Alexander G.
name: Lee, Man X.
name: Fujisawa, Sho
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy (ADT) synergizes with ionizing radiation (IR). Using a model of castration-resistant prostate cancer, we show that second-generation antiandrogen therapy results in downregulation of DNA repair genes. Next, we demonstrate that primary prostate cancers display a significant spectrum of AR transcriptional output which correlates with expression of a set of DNA repair genes. Employing RNA-seq and ChIP-seq, we define which of these DNA repair genes are both induced by androgen and represent direct AR targets. We establish that prostate cancer cells treated with IR plus androgen demonstrate enhanced DNA repair and decreased DNA damage and furthermore that antiandrogen treatment causes increased DNA damage and decreased clonogenic survival. Finally, we demonstrate that antiandrogen treatment results in decreased classical non-homologous end joining.
CUQ-GNN: Committee-based Graph Uncertainty Quantification using Posterior Networks
Creators: name: Damke, Clemens
name: Hüllermeier, Eyke
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: In this work, we study the influence of domain-specific characteristics when defining a meaningful notion of predictive uncertainty on graph data. Previously, the so-called Graph Posterior Network (GPN) model has been proposed to quantify uncertainty in node classification tasks. Given a graph, it uses Normalizing Flows (NFs) to estimate class densities for each node independently and converts those densities into Dirichlet pseudo-counts, which are then dispersed through the graph using the personalized Page-Rank algorithm. The architecture of GPNs is motivated by a set of three axioms on the properties of its uncertainty estimates. We show that those axioms are not always satisfied in practice and therefore propose the family of Committe-based Uncertainty Quantification Graph Neural Networks (CUQ-GNNs), which combine standard Graph Neural Networks with the NF-based uncertainty estimation of Posterior Networks (PostNets). This approach adapts more flexibly to domain-specific demands on the properties of uncertainty estimates. We compare CUQ-GNN against GPN and other uncertainty quantification approaches on common node classification benchmarks and show that it is effective at producing useful uncertainty estimates.
description: 17 pages, 4 figures, 1 table. Accepted at ECML PKDD 2024. arXiv admin note: substantial text overlap with arXiv:2406.04041
title: Digital Breast Tomosynthesis: slab thickness in the visualization of tomo only lesions
Creators: name: Sarachi, Ivelis
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Interventional non-vascular
subject: Image manipulation / Reconstruction
subject: Mammography
subject: Biopsy
subject: Outcomes
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To estimate the optimum slab thickness (ST) in the visualization of tomo only lesions (TO) without decreasing the diagnosis...
title: Medial collateral ligament injury in patients with medial femoral condyle edema and anterior cruciate ligament tear.
Creators: name: Sebaaly, Mikhael Georges
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal joint
subject: MR
subject: Imaging sequences
subject: Acute
subject: Trauma

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To find the mechanism of injury in patients with edema of medial rim of medial femoral condyle to help radiologist to look for other injured structures in such...
Lightest Kaluza-Klein graviton mode in a backreacted Randall-Sundrum scenario
Creators: name: Das, Ashmita
name: SenGupta, Soumitra
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In search of extra dimensions in the ongoing LHC experiments, signatures of Randall-Sundrum (RS) lightest KK graviton have been one of the main focus in recent years. The recent data from the dilepton decay channel at the LHC has determined the experimental lower bound on the mass of the RS lightest Kaluza-Klein (KK) graviton for different choices of underlying parameters of the theory. In this work we explore the effects of the backreaction of the bulk scalar field, which is employed to stabilise the RS model, in modifying the couplings of the lightest KK graviton with the standard model (SM) matter fields located on the visible brane. In such a modified background geometry we show that the coupling of the lightest KK graviton with the SM matter fields gets a significant suppression due to the inclusion of the backreaction of the bulk stabilising scalar field. This implies that the backreaction parameter weakens the signals from RS scenario in collider experiments which in turn explains the non-visibility of KK graviton in colliders. Thus we show that the modulus stabilisation plays a crucial role in the search of warped extra dimensions in collider experiments.
description: 12 pages, 1 figure
The criminalization of immigration in Italy: extent of the phenomenon and possible interpretations
Creators: name: Cecchi, Sergio
Publisher: name: QuiEdit
Year: 2015
Subjects: immigration; prison; inequality

description: This article investigates the relationship between immigration and crime inItaly. Although the number of crimes seems to be in constant decline, inItalythe social debate about the threat to law and order posed by immigrants still rages. While public initiatives to encourage the social integration of immigrants are practically nonexistent, policing of these groups has been redoubled leading to a rapid increase in incarceration rates. This article provides a critical interpretation of this process, seen as an instrument available to the political and financial elite inItalyto legitimize themselves in a period of crisis in the labour market and in a society where there are serious inequalities in the distribution of wealth.
description: Italian Sociological Review, Vol 1, No 1 (2011)
Narrative: in search of lost meaning
Creators: name: Lonardi, Cristina
Publisher: name: QuiEdit
Year: 2015
Subjects: narrative; reflexive biographies; identity

description: The de-institutionalization of biographies and life paths, and the fact that they are increasingly exposed to deviations with increasingly uncertain transient routes makes the personal biographies more and more reflexive and makes the identity of postmodern man more and more fragmented. In this way, narrating to oneself and narrating oneself to others is a way to recover at least some of the certainties lost in our liquid modernity. Narrative favours the construction or recomposition of identity. Indeed, the self takes shape and is structured by describing itself both inwardly and to others through a process of negotiating meaning. Additionally, in this way it is possible to reduce the fragmentary nature that characterises current biographies to some extent, recovering sense and meaning for one’s own experiences and identity, and managing to recognise oneself and be recognised through one’s personal social identity.
description: Italian Sociological Review, Vol 1, No 1 (2011)
GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1–TAB Stabilization and Regulation of Noncanonical NF-κB
Creators: name: Yeh, Jen Jen
name: Wilson, Willie
name: Baldwin, Albert S.
name: Bang, Deepali
name: Ryan, Meagan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Mutations in KRAS drive the oncogenic phenotype in a variety of tumors of epithelial origin. The NF-κB transcription factor pathway is important for oncogenic RAS to transform cells and to drive tumorigenesis in animal models. Recently TAK1, an upstream regulator of IKK, which controls canonical NF-κB, was shown to be important for chemoresistance in pancreatic cancer and for regulating KRAS+ colorectal cancer cell growth and survival. Here we show that KRAS+ upregulates GSK-3α leading to its interaction with TAK1 to stabilize the TAK1/TAB complex to promote IKK activity. Additionally, GSK-3α is required for promoting critical non-canonical NF-κB signaling in pancreatic cancer cells. Pharmacologic inhibition of GSK-3 suppresses growth of human pancreatic tumor explants, consistent with the loss of expression of oncogenic genes such as c-myc and TERT. These data identify GSK-3α as a key downstream effector of oncogenic KRAS via its ability to coordinately regulate distinct NF-κB signaling pathways.
title: Thoracic Amoebiasis- An unwanted ‘cell’ reception
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Respiratory system
subject: Thorax
subject: CT
subject: Plain radiographic studies
subject: Complications
subject: Epidemiology
subject: Infection
subject: Parasites

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The purpose of the study is to illustrate the imaging findings of thoracic amoebiasis, correlating them with X-ray and Computed tomographic images of the patients with clinically and microbiologically diagnosed...
Equilibrium of charged fluid around a Kerr black hole immersed in a magnetic field: variation of angular momentum
Creators: name: Trova, Audrey
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The present work presents analytically constructed equilibrium structures of charged perfect fluids orbiting Kerr Black holes embedded in an asymptotically uniform magnetic field. Our focus is on the effect of the non-constant angular momentum distribution through the disk, as well as its combined effect with the external magnetic field and the fluid charge. We demonstrate that the three parameters of our study have a significant impact on the various features of the accretion disk: the shape, the size of the disk and the characteristic of the fluid, as the pressure and the rest-mass density. Through our investigation, we observe substantial deviations from both the uncharged thick disk model and the charged disk model with constant angular momentum.
title: Weapon and munition inspired signs-Licensed to kill!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Bones
subject: Head and neck
subject: CT
subject: MR
subject: Plain radiographic studies
subject: Education
subject: Congenital
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The objective of this article is to demonstrate various radiological signs which were given names of weapons and munitions for easier recognition of pathologies by showing the radiological signs along with their associated weapons or...
(401868) Elizabeth Freer Whitson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Radiological secrets of Zika virus- Prenatal and postnatal findings in Zika virus infection.
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Foetal imaging
subject: CT
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Education
subject: Intrauterine diagnosis
subject: Congenital
subject: Foetus
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To understand the imaging features of congenital zika infection to assist early detection and offer appropriate counselling to parents. Identify the key distinguishing features from other vertically transmitted diseases and chromosomal...
Improving the precision matrix for precision cosmology
Creators: name: Paz, Dante J.
name: Sanchez, Ariel G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The estimation of cosmological constraints from observations of the large scale structure of the Universe, such as the power spectrum or the correlation function, requires the knowledge of the inverse of the associated covariance matrix, namely the precision matrix, $\mathbfΨ$. In most analyses, $\mathbfΨ$ is estimated from a limited set of mock catalogues. Depending on how many mocks are used, this estimation has an associated error which must be propagated into the final cosmological constraints. For future surveys such as Euclid and DESI, the control of this additional uncertainty requires a prohibitively large number of mock catalogues. In this work we test a novel technique for the estimation of the precision matrix, the covariance tapering method, in the context of baryon acoustic oscillation measurements. Even though this technique was originally devised as a way to speed up maximum likelihood estimations, our results show that it also reduces the impact of noisy precision matrix estimates on the derived confidence intervals, without introducing biases on the target parameters. The application of this technique can help future surveys to reach their true constraining power using a significantly smaller number of mock catalogues.
description: 9 pages, 7 figures, minor changes to match version accepted by MNRAS
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
Creators: name: Cohoon, Travis J.
name: Bailey, Sean T.
name: Kwiatkowski, David J.
name: Janne, Pasi A.
name: Engelman, Jeffrey A.
name: Carretero, Julian
name: Choe, Sung
name: Bardeesy, Nabeel
name: Neil Hayes, D.
name: Patel, Nirali M.
name: Marks, Kevin
name: Altabef, Abigail B.
name: Wang, Xiaoxu
name: Sharpless, Norman E.
name: Heymach, John V.
name: Cowley, Glenn S.
name: Manning, Brendan D.
name: Kim, William Y.
name: Asara, John M.
name: Tchaicha, Jeremy H.
name: Liu, Qingsong
name: Cantley, Lewis C.
name: Gray, Nathanael S.
name: Zhang, Jianming
name: Xu, Chunxiao
name: Byers, Lauren A.
name: Gibbons, Don L.
name: Gao, Peng
name: Driggers, Edward M.
name: Root, David E.
name: Wong, Kwok Kin
name: Kimmelman, Alec
name: Liu, Yan
name: Shaw, Reuben J.
name: Niel, Thomas J.F.
name: Zhang, Yong
name: Kung, Andrew L.
name: Wistuba, Ignacio I.
name: Scully, Ralph
name: Chen, Zhao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung cancer, LKB1 is somatically inactivated in 25-30% of cases, often concurrently with activating KRAS mutation. Here, we employed an integrative approach to define novel therapeutic targets in KRAS-driven LKB1 mutant lung cancers. High-throughput RNAi screens in lung cancer cell lines from genetically engineered mouse models driven by activated KRAS with or without coincident Lkb1 deletion led to the identification of Dtymk, encoding deoxythymidylate kinase which catalyzes dTTP biosynthesis, as synthetically lethal with Lkb1 deficiency in mouse and human lung cancer lines. Global metabolite profiling demonstrated that Lkb1-null cells had striking decreases in multiple nucleotide metabolites as compared to the Lkb1-wt cells. Thus, LKB1 mutant lung cancers have deficits in nucleotide metabolism conferring hypersensitivity to DTYMK inhibition, suggesting that DTYMK is a potential therapeutic target in this aggressive subset of tumors.
Practice Abstract - Modeling the Economics of Food Loss and Waste from Farm to Fork
Creators: name: Drabik, Dušan
Publisher: name: Zenodo
Year: 2023
Subjects: Economic modeling of FLW, economic modeling, Food Loss, Food Waste, FLW, Food Loss & Waste, Consumer Behaviour, Demand Elasticities, consumer waste

description: This practice abstract explains why modeling the economics behind FLW is important in order to reduce FLW from farm to fork and how this work package will approach developing and testing their model through the project's Systemic Innovation Living Labs within FLW.
Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Creators: name: Wang, Yufang
name: Der, Channing J.
name: Velho, Sérgia
name: Bass, Adam J.
name: Philips, Mark
name: Gierut, Jessica
name: Peng, Shouyong
name: Bugni, James M.
name: Haigis, Kevin M.
name: Solit, David B.
name: Chu, Gerald C.
name: Vakiani, Efsevia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: N-Ras is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in N-Ras occur in a subset of colorectal cancers, but little in known about how the mutant protein contributes to onset and progression of the disease. Using genetically engineered mice, we find that mutant N-Ras strongly promotes tumorigenesis in the context of inflammation. The pro-tumorigenic nature of mutant N-Ras is related to its anti-apoptotic function, which is mediated by activation of a non-canonical MAPK pathway that signals through Stat3. As a result, inhibition of MEK selectively induces apoptosis in autochthonous colonic tumors expressing mutant N-Ras. The translational significance of this finding is highlighted by our observation that NRAS mutation correlates with a less favorable clinical outcome for colorectal cancer patients. These data demonstrate for the first time the important role that N-Ras plays in colorectal cancer.\
title: Imaging of Encephalocele – “seeking a closure”
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Foetal imaging
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Ultrasound
subject: Computer Applications-3D
subject: Diagnostic procedure
subject: Congenital
subject: Developmental disease
subject: Foetus

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To formulate an approach through adequate understanding of anatomy, prognostic factors, and abnormalities associated with...
title: Animalise this! Pictorial review on animal inspired signs in radiology
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Head and neck
subject: Musculoskeletal system
subject: CT
subject: MR
subject: Plain radiographic studies
subject: Education
subject: Connective tissue disorders
subject: Developmental disease
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Enumerate popular radiological signs that drew inspiration from animals and thus detail radiological features in various...
The Genomic Landscape of Breast Cancer as a Therapeutic Roadmap
Creators: name: Perou, Charles M.
name: Ellis, Matthew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The application of high throughput techniques to profile DNA, RNA and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiological events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Research Focus we summarize some of the headline conclusions from six recent breast cancer ‘omics profiling’ papers in Nature, with an emphasis on the implications for systemic therapy.
Radio emission from Supernova Remnants
Creators: name: Dubner, Gloria
name: Giacani, Elsa
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The explosion of a supernova releases almost instantaneously about 10^51 ergs of mechanic energy, changing irreversibly the physical and chemical properties of large regions in the galaxies. The stellar ejecta, the nebula resulting from the powerful shock waves, and sometimes a compact stellar remnant, constitute a supernova remnant (SNR). They can radiate their energy across the whole electromagnetic spectrum, but the great majority are radio sources. Almost 70 years after the first detection of radio emission coming from a SNR, great progress has been achieved in the comprehension of their physical characteristics and evolution. We review the present knowledge of different aspects of radio remnants, focusing on sources of the Milky Way and the Magellanic Clouds, where the SNRs can be spatially resolved. We present a brief overview of theoretical background, analyze morphology and polarization properties, and review and critical discuss different methods applied to determine the radio spectrum and distances. The consequences of the interaction between the SNR shocks and the surrounding medium are examined, including the question of whether SNRs can trigger the formation of new stars. Cases of multispectral comparison are presented. A section is devoted to reviewing recent results of radio SNRs in the Magellanic Clouds, with particular emphasis on the radio properties of SN 1987A, an ideal laboratory to investigate dynamical evolution of an SNR in near real time. The review concludes with a summary of issues on radio SNRs that deserve further study, and analyzing the prospects for future research with the latest generation radio telescopes.
description: Revised version. 48 pages, 15 figures
Practice Abstract - 0FLW dataspace
Creators: name: Cornelisse, Erik
Publisher: name: Zenodo
Year: 2023
Subjects: Dataspace, Food Loss, Food Loss & Waste, Food Waste, FLW, IT infrastructure, data infrastructure, innovation, data handling, FLW data

description: This Practice Abstracts describes the concept of a secure dataspace for sharing data on FLW. The result will be a generic IT infrastructure which can function as the basiscs of a 0FLW data exosystem. This is part of the ZeroW project's work package 1.
A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner
Creators: name: Bultman, Scott J.
name: Godfrey, Virginia
name: Hillhouse, Andrew
name: Ryan, Elizabeth P.
name: Heise, Mark T.
name: Threadgill, Deborah S.
name: Greenwalt, Alicia
name: Renner, Sarah W.
name: Holley, Darcy
name: Montgomery, Stephanie A.
name: Curry, Kaitlin P.
name: Donohoe, Dallas R.
name: Whitmore, Alan C.
name: Swenberg, James A.
name: Threadgill, David W.
name: Han, Anna
name: Collins, Leonard B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: It is controversial whether dietary fiber protects against colorectal cancer because of conflicting results from human epidemiologic studies. However, these studies and mouse models of colorectal cancer have not controlled the composition of gut microbiota, which ferment fiber into short-chain fatty acids such as butyrate. Butyrate is noteworthy because it has energetic and epigenetic functions in colonocytes and tumorsuppressive properties in colorectal-cancer cell lines. We utilized gnotobiotic mouse models colonized with wild-type or mutant strains of a butyrate-producing bacterium to demonstrate that fiber does have a potent tumor-suppressive effect but in a microbiota- and butyrate-dependent manner. Furthermore, due to the Warburg effect, butyrate was metabolized less in tumors where it accumulated and functioned as an HDAC inhibitor to stimulate histone acetylation and affect apoptosis and cell proliferation. To support the relevance of this mechanism in human cancer, we demonstrate that butyrate and histone-acetylation levels are elevated in colorectal adenocarcinomas compared to normal colonic tissues.
(401869) Mary Hope Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma
Creators: name: Sharpless, Norman E.
name: Huynh, Minh V.
name: Campbell, Sharon L.
name: Liu, Wenjin
name: Baguley, Bruce C.
name: Fu, Kailing
name: Souroullas, George P.
name: Miley, Michael J.
name: Darr, David B.
name: Zedek, Daniel C.
name: Gillahan, James E.
name: Burd, Christin E.
name: Waqas, Meriam A.
name: Clark, Kelly S.
name: Martin, Brit L.
name: Jeck, William R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-RasQ61R knock-in allele to similarly designed K-RasG12D and N-RasG12D alleles. With concomitant p16INK4a inactivation, K-RasG12D or N-RasQ61R expression efficiently promoted melanoma in vivo, whereas N-RasG12D did not. Additionally, N-RasQ61R mutation potently cooperated with Lkb1/Stk11 loss to induce highly metastatic disease. Functional comparisons of N-RasQ61R and N-RasG12D revealed little difference in the ability of these proteins to engage PI3K or RAF. Instead, N-RasQ61R showed enhanced nucleotide binding, decreased intrinsic GTPase activity and increased stability when compared to N-RasG12D. This work identifies a faithful model of human N-RAS mutant melanoma, and suggests that the increased melanomagenecity of N-RasQ61R over N-RasG12D is due to heightened abundance of the active, GTP-bound form rather than differences in the engagement of downstream effector pathways.
NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function
Creators: name: Xu, Bowen
name: Gough, Sheryl M.
name: Denu, John M.
name: Meltzer, Paul S.
name: Onozawa, Masahiro
name: Yang, Fan
name: Zhu, Yeulin J.
name: Lee, Fan
name: Ning, Yi
name: Wang, Gang Greg
name: Walker, Robert L.
name: Aplan, Peter D.
name: Pineda, Marbin
name: Bilke, Sven
name: Wagner, Elise K.
name: Chung, Yang Jo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and pre-leukemic tissues display a stem cell-like expression signature including Hoxa, Hoxb, and Meis1 genes. The PHF23 PHD domain is known to bind H3K4me3 residues, and chromatin immunoprecipitation experiments demonstrated that the NP23 protein bound chromatin at a specific subset of H3K4me3 sites, including Hoxa, Hoxb, and Meis1. Treatment of NP23 cells with disulfiram, which inhibits the binding of PHD domains to H3K4me3 residues, rapidly and selectively killed NP23 myeloblasts; cell death was preceded by decreased expression of Hoxa, Hoxb, and Meis1. Furthermore, AML driven by a related fusion gene, NUP98-JARID1A (NJL), was also sensitive to disulfiram. Thus, the NP23 mouse provides a platform to evaluate compounds that disrupt binding of oncogenic PHD proteins to H3K4me3.
Measurement of the Nodal Precession of WASP-33 b via Doppler Tomography
Creators: name: Johnson, Marshall C.
name: Cochran, William D.
name: Cameron, Andrew Collier
name: Bayliss, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have analyzed new and archival time series spectra taken six years apart during transits of the hot Jupiter WASP-33 b, and spectroscopically resolved the line profile perturbation caused by the Rossiter-McLaughlin effect. The motion of this line profile perturbation is determined by the path of the planet across the stellar disk, which we show to have changed between the two epochs due to nodal precession of the planetary orbit. We measured rates of change of the impact parameter and the sky-projected spin-orbit misalignment of $db/dt=-0.0228_{-0.0018}^{+0.0050}$ yr$^{-1}$ and $dλ/dt=-0.487_{-0.076}^{+0.089}$~$^{\circ}$ yr$^{-1}$, respectively, corresponding to a rate of nodal precession of $dΩ/dt=0.373_{-0.083}^{+0.031}$~$^{\circ}$ yr$^{-1}$. This is only the second measurement of nodal precession for a confirmed exoplanet transiting a single star. Finally, we used the rate of precession to set limits on the stellar gravitational quadrupole moment of $9.4\times10^{-5}
description: Published in ApJL. 5 pages, 3 figures. Corrected error in the calculation of J_2
Intratumoral Heterogeneity in a Trp53-Null Mouse Model of Human Breast Cancer
Creators: name: Wolff, Andrew
name: Hilsenbeck, Susan G.
name: Chang, Chi Hsuan
name: Perou, Charles M.
name: Rosen, Jeffrey M.
name: Fan, Cheng
name: Zhang, Mei
name: Tsimelzon, Anna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Intratumoral heterogeneity correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. Such heterogeneity is thought to contribute to radio- and chemoresistance since many treatments may only target certain tumor cell subpopulations. A better understanding of the functional interactions between various subpopulations of cells, therefore, may help in the development of effective cancer treatments. We identified a unique subpopulation of tumor cells expressing mesenchymal-like markers in a p53 null mouse model of basal-like breast cancer using fluorescence-activated cell sorting and microarray analysis. Both in vitro and in vivo experiments revealed the existence of crosstalk between these “mesenchymal-like” cells and tumor-initiating cells. Knockdown of genes encoding ligands upregulated in the mesenchymal cells and their corresponding receptors in the tumor-initiating cells resulted in reduced tumorigenicity and increased tumor latency. These studies illustrate the non-cell autonomous properties and importance of cooperativity between tumor subpopulations.
Project Abstract - Assessing and Monitoring the Development of Systems
Creators: name: Van den Bossche, Lisa
Publisher: name: Zenodo
Year: 2023
Subjects: food loss, food waste, systemic food loss, systemic food loss and waste, systemic food waste, systemic innovation, monitoring tool, assessing tool,

description: This Practice Abstract suggest to use a "Systemic Innovation Readiness Level" as a tool to assess and monitor the innovations created for solving issues within systemic food loss and waste. The practice abstract explains the necessity and outlines the tool which is being tested in the project.
Supplementary material for "Real option valuation of a decremental regulation service provided by electricity storage"
Creators: name: Szabó, Dávid Zoltán
name: Martyr, Randall
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: This paper is a quantitative study of a reserve contract for real-time balancing of a power system. Under this contract, the owner of a storage device, such as a battery, helps smooth fluctuations in electricity demand and supply by using the device to increase electricity consumption. The battery owner must be able to provide immediate physical cover, and should therefore have sufficient storage available in the battery before entering the contract. Accordingly, the following problem can be formulated for the battery owner: determine the optimal time to enter the contract and, if necessary, the optimal time to discharge electricity before entering the contract. This problem is formulated as one of optimal stopping, and is solved explicitly in terms of the model parameters and instantaneous values of the power system imbalance. The optimal operational strategies thus obtained ensure that the battery owner has positive expected economic profit from the contract. Furthermore, they provide explicit conditions under which the optimal discharge time is consistent with the overall objective of power system balancing. This paper also carries out a preliminary investigation of the ‘lifetime value’ aggregated from an infinite sequence of these balancing reserve contracts. This lifetime value, which can be viewed as a single project valuation of the battery, is shown to be positive and bounded. Therefore, in the long run such reserve contracts can be beneficial to commercial operators of electricity storage, while reducing some of the financial and operational risks in power system balancing.
title: The Labour of the Lungs - Imaging of Occupational Lung Diseases
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Respiratory system
subject: CT
subject: Plain radiographic studies
subject: Education
subject: Occupational / Environmental hazards
subject: Toxicity

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Occupational lung disease comprises a wide variety of disorders caused by the inhalation or ingestion of dust particles or noxious chemicals. These sources include factories, smokestacks, exhaust, fires, mining, construction, and agriculture. The...
Topological Quantum Materials with Kagome Lattice
Creators: name: Wang, Qi
name: Lei, Hechang
name: Qi, Yanpeng
name: Felser, Claudia
Publisher: name: arXiv
Year: 2024
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In this account, we will give an overview of our research progress on novel quantum properties in topological quantum materials with kagome lattice. Here, there are mainly two categories of kagome materials: magnetic kagome materials and nonmagnetic ones. On one hand, magnetic kagome materials mainly focus on the 3d transition-metal-based kagome systems, including Fe$_3$Sn$_2$, Co$_3$Sn$_2$S$_2$, YMn6Sn6, FeSn, and CoSn. The interplay between magnetism and topological bands manifests vital influence on the electronic response. For example, the existence of massive Dirac or Weyl fermions near the Fermi level signicantly enhances the magnitude of Berry curvature in momentum space, leading to a large intrinsic anomalous Hall effect. In addition, the peculiar frustrated structure of kagome materials enables them to host a topologically protected skyrmion lattice or noncoplaner spin texture, yielding a topological Hall effect that arises from the realspace Berry phase. On the other hand, nonmagnetic kagome materials in the absence of longrange magnetic order include CsV3Sb5 with the coexistence of superconductivity, charge density wave state, and band topology and van der Waals semiconductor Pd$_3$P$_2$S$_8$. For these two kagome materials, the tunability of electric response in terms of high pressure or carrier doping helps to reveal the interplay between electronic correlation effects and band topology and discover the novel emergent quantum phenomena in kagome materials.
description: 10 pages,7 figures
title: Imaging of Extra adrenal Pheochromocytoma - Alone I Stand
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Retroperitoneum
subject: CT
subject: MR
subject: Education
subject: Localisation
subject: Endocrine disorders
subject: Hypertension

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Extra-adrenal Pheochromoctoma alias Paragangliomas are a rare neuroendocrine tumor arising from the neuroectodermally derived paraganglionic cells scattered throughout the...
Magnetic properties of LiCu$_3$O$_3$ -- quasi-two-dimensional antiferromagnet on depleted square lattice
Creators: name: Bush, A. A.
name: Gotovko, S. K.
name: Ivanov, V. Yu.
name: Kozlov, V. I.
name: Nikolaev, E. G.
name: Svistov, L. E.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: LiCu$_3$O$_3$ is a novel 2D S=1/2 antiferromagnet with randomly depleted square lattice. The crystal structure contains two types of square planes with different Cu$^{2+}\rightarrow$ Li$^{+}$ substitution rates (20% and 40%). $^7$Li NMR and magnetization measurements performed on single crystals of LiCu$_3$O$_3$ revealed the occurrence of magnetic order at $T_{c1}=123$ K and the change of the magnetic state at $T_{c2}\approx30$ K. The high temperature transition can be attributed to establishment of magnetic order in planes with higher concentration of magnetic ions and the low temperature transition -- to the magnetic ordering in planes with lower concentration of magnetic ions. Broad continuous NMR spectra below $T_{c1}$ reflect a continuous distribution of values or directions of magnetic moments in LiCu$_3$O$_3$ typical for spiral, spin-modulated magnetic structures or structures with frozen disorder. Magnetization measurements revealed a spin-flop transition which indicates weak uniaxial anisotropy of the spin structure. Relatively small value of magnetic susceptibility at all orientations of applied magnetic field shows that magnetic structure is rigid, since the estimated value of saturation field derived from differential susceptibility measured at $μ_0 H=5$ T is $μ_0H_{sat} \approx$200 T.
description: 11 pages, 12 figures
(401870) Thomas Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Imaging of Craniofacial anomalies - Imaging of Incomplete Skull Décor
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Ear / Nose / Throat
subject: Foetal imaging
subject: CT
subject: MR
subject: Ultrasound
subject: Computer Applications-3D
subject: Education
subject: Congenital
subject: Developmental disease
subject: Foetus

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Craniofacial anomalies (CFA) are group of congenital abnormalities in the bone or soft tissue of the face or head. Prenatal sonographic craniofacial anomalies can be diagnosed in early gestation. Antenatal ultrasonography is a precise and reliable...
Appendix S1 from Physiological thermal limits predict differential responses of bees to urban heat-island effects.
Creators: name: Hamblin, April L.
name: Youngsteadt, Elsa
name: López-Uribe, Margarita M.
name: Frank, Steven D.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Supplemental methods and results
Limit sets, Julia sets and Sullivan’s dictionary : a dimension theoretic analysis
Creators: name: Stuart, Liam
Publisher: name: The University of St Andrews
Year: 2023
Subjects: Fractals
Dimension theory
Assouad dimension
Assouad spectrum
Kleinian group
Limit set
Rational map
Julia set
Sullivan's dictionary
Horoballs

description: This thesis includes work from four papers that were written during the author’s time as a PhD student with Jonathan Fraser, namely [40, 41, 42, 43]. Chapter 1 introduces the two main settings that will be studied throughout this thesis along with several tools that will be used. This will include various notions of dimensions of sets and measures, the setting of hyperbolic geometry and limit sets, and the setting of rational maps and Julia sets. Chapter 2 will state and prove results in the hyperbolic geometry setting, where we calculate the Assouad and lower spectra for limit sets of geometrically finite Kleinian groups along with their associated Patterson-Sullivan measure. The broad approach takes some ideas from [35] where the Assouad and lower dimensions were calculated, but many of the ideas require adjustment or replacement due to the Assouad and lower spectra requiring finer control. An important tool made use of is the notion of a ‘global measure formula’ in order to obtain estimates on efficient covers. Chapter 3 involves adapting this approach to calculate the Assouad type dimensions of Julia sets of parabolic rational maps and their associated h-conformal measures, where h denotes the Hausdorff dimension of the Julia set. Chapter 4 is then dedicated to a discussion of the results in Chapters 2 and 3 in the context of Sullivan’s dictionary, a framework which draws many connections between the settings of hyperbolic geometry and rational maps. We draw several interesting parallels between the two settings, along with some notable differences, using our results on the Assouad type dimensions which are not witnessed by other notions of dimension. In Chapter 5, we obtain results for counting horoballs of certain sizes, and then discuss some applications of these results to Diophantine approximation and the calculation of dimensions of conformal measures. We finish in Chapter 6 with discussion about further questions which stem from our research.
Appendix S1 from Physiological thermal limits predict differential responses of bees to urban heat-island effects
Creators: name: Hamblin, April L.
name: Youngsteadt, Elsa
name: López-Uribe, Margarita M.
name: Frank, Steven D.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Supplemental methods and results