cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
La Valutazione dei Servizi Ecosistemici. Proposta per un Approccio Termoeconomico
Creators: name: Longhitano, Davide
name: Longhitano, Davide
Publisher: name: Unknown
Year: 2012
Subjects: subject: Resource /Energy Economics and Policy
subject: thermoeconomic approach
subject: agroecosystem services
subject: exergy
subject: emergy
subject: environmental accounting

description: The main objective of this communication is to review the theoretical ecosystem and agroecosystem services assessment’s methods and to propose a thermoeconomic approach. The logic of thermoeconomic approach consists in analysing the use of natural resources during the production process, interpreting it as a thermodynamic conversion in order to assess the overall specific energy consumption of the systemic components arriving at estimates of fluxes and energy costs. This study analyses comparatively the main thermoeconomic-based approaches to verify the feasibility of the "energy value" as an appraisal criterion of agroecosystem services. In particularly among the reviewed approaches the Emergy synthesis seems the most appropriate tool to be empirically applied on the study of agricultural systems even at the farm level, and this in particular taking into account the new architecture of the database of the Italian FADN, although they are complementary tools to traditional methods of decision analysis.
The impact of routine childhood immunization with higher-valent pneumococcal conjugate vaccines on antimicrobial-resistant pneumococcal diseases and carriage: a systematic literature review
Creators: name: Myint Tin Tin Htar
name: Biggelaar, Anita H.J. Van Den
name: Sings, Heather
name: Ferreira, Germano
name: Moffatt, Margaret
name: Hall-Murray, Cassandra
name: Verstraeten, Thomas
name: Gessner, Bradford D.
name: Heinz-Josef Schmitt
name: Jodar, Luis
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Introduction: The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in childhood immunization programs reduced antimicrobial-resistant pneumococcal infections by vaccine serotypes. However, emerging antimicrobial-resistant non-vaccine serotypes, particularly serotype 19A, attenuated the overall effect. In 2010, higher-valent PCVs became available containing serotypes that are prone to become antimicrobial-resistant, like serotype 7F in PCV10 and PCV13, and serotype 19A in PCV13. Areas covered: This review evaluated literature published between June 1, 2008 and June 1, 2017 reporting on the effect of PCV10 or PCV13 implementation in routine infant immunization schedules on antimicrobial-resistant invasive pneumococcal disease (IPD), otitis media (OM), and nasopharyngeal carriage (NPC) in children and adults. Expert opinion: In countries with relatively high prior pneumococcal antimicrobial resistance (AMR), PCV13 childhood vaccination programs have reduced antimicrobial-resistant IPD, OM, and NPC in children and IPD in adults. The effectiveness of PCV13 against serotype 19A is likely an important contributing factor. Only few studies have documented the impact of PCV10 on AMR. Multiple factors may influence observed decreases in pneumococcal AMR including antimicrobial stewardship, case definition, time since PCV10/13 introduction, and pre-PCV10/13 AMR levels. This review emphasizes the importance of including impact on AMR when evaluating the full public health of pneumococcal vaccination programs.
An examination of the effect of the TESS extended mission on southern hemisphere monotransits
Creators: name: Cooke, Benjamin F.
name: Pollacco, Don
name: Bayliss, Daniel
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context: NASA recently announced an extended mission for TESS. As a result it is expected that the southern ecliptic hemisphere will be re-observed approximately two years after the initial survey. Aims: We aim to explore how TESS re-observing the southern ecliptic hemisphere will impact the number and distribution of mono-transits discovered during the first year of observations. This simulation will be able to be scaled to any future TESS re-observations. Methods: We carry out an updated simulation of TESS detections in the southern ecliptic hemisphere. This simulation includes realistic Sector window-functions based on the first 11 sectors of SPOC 2 min SAP lightcurves. We then extend this simulation to cover the expected Year 4 of the mission when TESS will re-observed the southern ecliptic fields. For recovered monotransits we also look at the possibility of predicting the period based on the coverage in the TESS data. Results: We find an updated prediction of 339 monotransits from the TESS Year 1 southern ecliptic hemisphere, and that approximately 80% of these systems (266/339) will transit again in the Year 4 observations. The Year 4 observations will also contribute new monotransits not seen in Year 1, resulting in a total of 149 monotransits from the combined Year 1 and Year 4 data sets. We find that 75% (189/266) of recovered Year 1 monotransits will only transit once in the Year 4 data set. For these systems we will be able to constrain possible periods, but period aliasing due to the large time gap between Year 1 and Year 4 observations means that the true period will remain unknown with further spectroscopic or photometric follow-up.
description: 6 pages, 6 figures. Version to be published Astronomy and Astrophysics
Ion pairing in model electrolytes: A study via three particle correlation functions
Creators: name: Jimenez-Angeles, Felipe
name: Messina, Rene
name: Holm, Christian
name: Lozada-Cassou, Marcelo
Publisher: name: arXiv
Year: 2002
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A novel integral equations approach is applied for studying ion pairing in the restricted primitive model (RPM) electrolyte, i. e., the three point extension (TPE) to the Ornstein-Zernike integral equations. In the TPE approach, the three-particle correlation functions $g^{[3]}({\bf r}_{1},{\bf r}_{2},{\bf r}_{3})$ are obtained. The TPE results are compared to molecular dynamics (MD) simulations and other theories. Good agreement between TPE and MD is observed for a wide range of parameters, particularly where standard integral equations theories fail, i. e., low salt concentration and high ionic valence. Our results support the formation of ion pairs and aligned ion complexes.
description: 43 pages (including 18 EPS figs) - RevTeX 4 - J. Chem. Phys. (in press)
Oncopagurus indicus
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Parapaguridae
Oncopagurus
Oncopagurus indicus

description: Oncopagurus indicus (Alcock, 1905)
 Sympagurus bicristatus var. indicus Alcock, 1905: 105, pl. 10, fig. 4 [type locality: Andaman Sea; syntypes: IM?].
 Hawaiian Is. records:
 Parapagurus bicristatus indicus (Alcock, 1905) — de Saint Laurent 1972: 112 [H.I.].
 Oncopagurus indicus (Alcock, 1905) — Lemaitre 1996: 195, figs. 17, 18 [O‘ahu, Moloka‘i, Pailolo Channel east of Moloka‘i, Maui].
 Taxonomy. Lemaitre (1996)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Sometimes carries sea anemones on the gastropod shell; subtidal to bathyal, 183–1480 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 29, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
Toward the Understanding of Topographical and Spectral Signatures of Infant Movement Artifacts in Naturalistic EEG
Creators: name: Georgieva, Stanimira
name: Lester, Suzannah
name: Noreika, Valdas
name: Yilmaz, Meryem Nazli
name: Wass, Sam
name: Leong, Victoria
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Neuroscience
electroencephalography
signal distortion
motion artifacts
infants
naturalistic paradigm

description: Electroencephalography (EEG) is perhaps the most widely used brain-imaging technique for pediatric populations. However, EEG signals are prone to distortion by motion. Compared to adults, infants’ motion is both more frequent and less stereotypical yet motion effects on the infant EEG signal are largely undocumented. Here, we present a systematic assessment of naturalistic motion effects on the infant EEG signal. EEG recordings were performed with 14 infants (12 analyzed) who passively watched movies whilst spontaneously producing periods of bodily movement and rest. Each infant produced an average of 38.3 s (SD = 14.7 s) of rest and 18.8 s (SD = 17.9 s) of single motion segments for the final analysis. Five types of infant motions were analyzed: Jaw movements, and Limb movements of the Hand, Arm, Foot, and Leg. Significant movement-related distortions of the EEG signal were detected using cluster-based permutation analysis. This analysis revealed that, relative to resting state, infants’ Jaw and Arm movements produced significant increases in beta (∼15 Hz) power, particularly over peripheral sites. Jaw movements produced more anteriorly located effects than Arm movements, which were most pronounced over posterior parietal and occipital sites. The cluster analysis also revealed trends toward decreased power in the theta and alpha bands observed over central topographies for all motion types. However, given the very limited quantity of infant data in this study, caution is recommended in interpreting these findings before subsequent replications are conducted. Nonetheless, this work is an important first step to inform future development of methods for addressing EEG motion-related artifacts. This work also supports wider use of naturalistic paradigms in social and developmental neuroscience.
Large Effects of Particle Size Heterogeneity on Dynamic Saltation Threshold
Creators: name: Zhu, Wei
name: Huo, Xinghui
name: Zhang, Jie
name: Wang, Peng
name: Pähtz, Thomas
name: Huang, Ning
name: He, Zhiguo
Publisher: name: arXiv
Year: 2019
Subjects: subject: Geophysics (physics.geo-ph)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Reliably predicting the geomorphology and climate of planetary bodies requires knowledge of the dynamic threshold wind shear velocity below which saltation transport ceases. Here we measure this threshold in a wind tunnel for four well-sorted and two poorly sorted sand beds by visual means and by a method that exploits a regime shift in the behavior of the surface roughness caused by momentum transfer from the wind to the saltating particles. For our poorly sorted sands, we find that these measurement methods yield different threshold values because, at the smaller visual threshold, relatively coarse particles do not participate in saltation. We further find that both methods yield threshold values that are much larger (60--250\%) for our poorly sorted sands than for our well-sorted sands with similar median particle diameter. In particular, even a rescaling of the dynamic saltation threshold based on the 90th percentile particle diameter rather than the median diameter cannot fully capture this difference, suggesting that relatively very coarse particles have a considerable control on the dynamic threshold. Similar findings were previously reported for water-driven sediment transport. Our findings have important implications for quantitative predictions of saltation transport-related geophysical processes, such as dust aerosol emission.
Assessing agriculture-water relationships: a Pan-European multidimensional modelling approach
Creators: name: Blanco, Maria
name: Van Doorslaer, Benjamin
name: Britz, Wolfgang
name: Blanco, Maria
name: Van Doorslaer, Benjamin
name: Britz, Wolfgang
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: agricultural policy
subject: agro-economic modelling
subject: food-water linkages
subject: bioeconomy

description: Irrigation water use by agriculture has been identified as one of the major sustainable water management issues in the implementation of the Water Framework Directive (WFD). This paper aims at developing a simulation framework to jointly assess agricultural and water issues. While the strong linkages between water, food, and the environment call for an integrated and multidisciplinary modelling approach, a complete and consistent modelling system to evaluate food-water relationships in Europe was missing so far. The spatial economic simulation model for agriculture CAPRI, which comprises a set of environmental indicators to assess food-environment interrelations within European regions, has been extended to account for food-water links. This modelling framework enables simulating the potential impact of climate change and water availability on agricultural production at the EU regional level, as well as looking at the sustainable use of water, the implementation of water policies or the integration of water issues in the Common Agricultural Policy.
Polarized Spacetime Foam
Creators: name: Dzhunushaliev, V.
Publisher: name: arXiv
Year: 2001
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An approximate model of a spacetime foam is presented. It is supposed that in the spacetime foam each quantum handle is like to an electric dipole and therefore the spacetime foam is similar to a dielectric. If we neglect of linear sizes of the quantum handle then it can be described with an operator containing a Grassman number and either a scalar or a spinor field. For both fields the Lagrangian is presented. For the scalar field it is the dilaton gravity + electrodynamics and the dilaton field is a dielectric permeability. The spherically symmetric solution in this case give us the screening of a bare electric charge surrounded by a polarized spacetime foam and the energy of the electric field becomes finite one. In the case of the spinor field the spherically symmetric solution give us a ball of the polarized spacetime foam filled with the confined electric field. It is shown that the full energy of the electric field in the ball can be very big.
description: essential changes in the text
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Creators: name: Nyimanu, Duuamene
name: Kay, Richard G.
name: Sulentic, Petra
name: Kuc, Rhoda E.
name: Ambery, Philip
name: Jermutus, Lutz
name: Reimann, Frank
name: Gribble, Fiona M.
name: Cheriyan, Joseph
name: Maguire, Janet J.
name: Davenport, Anthony P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/1647/296
/692/308/575
/82
/82/58
/96
/96/106
article

description: Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability in humans. We therefore aimed to develop an LC-MS/MS method for detection and quantification of intact [Pyr1]apelin-13 and have used this method to identify the metabolites generated in vivo in humans. [Pyr1]apelin-13 (135 nmol/min) was infused into six healthy human volunteers for 120 minutes and blood collected at time 0 and 120 minutes after infusion. Plasma was extracted in the presence of guanidine hydrochloride and analysed by LC-MS/MS. Here we report a highly sensitive, robust and reproducible method for quantification of intact [Pyr1]apelin-13 and its metabolites in human plasma. Using this method, we showed that the circulating concentration of intact peptide was 58.3 ± 10.5 ng/ml after 120 minutes infusion. We demonstrated for the first time that in humans, [Pyr1]apelin-13 was cleaved from both termini but the C-terminal was more susceptible to cleavage. Consequently, of the metabolites identified, [Pyr1]apelin-13(1–12), [Pyr1]apelin-13(1–10) and [Pyr1]apelin-13(1–6) were the most abundant. These data suggest that apelin peptides designed for use as cardiovascular therapeutics, should include modifications that minimise C-terminal cleavage.
Effects of feeding schedule on growth, production and economics of pangasiid catfish (Pangasius hypophthalmus) and silver carp (Hypophthalmichthys molitrix) polyculture
Creators: name: Khan, S.
name: Hossain, M.S
name: Haque, M.M
name: Khan, S.
name: Hossain, M.S
name: Haque, M.M
Publisher: name: Unknown
Year: 2009
Subjects: Livestock Production/Industries
Production Economics
Productivity Analysis

description: An experiment was carried out to evaluate the effects of feeding schedule on growth, production and economics of pangasiid catfish (Pangasius hypophthalmus) and silver carp (Hypophthalmichthys molitrix) polyculture in nine earthen ponds for a period of 135 days. There were three treatments (T) each with three replications. Species composition (1:1) and stocking density (25,000 fish/ha) were same in all treatments. A commercially available pelleted feed was given only for pangasiid catfish with same feeding rate in all treatments but the feeding frequency was different. The feeding rate was 10%, 8%, 7%, 6 %, 5%, 4% which was consecutively adjusted after each fortnightly sampling and 3% for the last 4 weeks of the study period. Feeding frequencies was once a day in T1, two times a day in T2 and three times a day in T3. The average weight gain of pangasiid catfish and silver carp in T3 (376.69 g and 81.02 g) was significantly higher (P<0.05) than those of T2 (330.25 g and 58.35 g) and T1 (261.76 g and 42.89 g). The survival rate was 95.2, 96.0 and 96.8% for pangasiid catfish and 83.2, 85.2 and 86.0% for silver carp in T1, T2 and T3, respectively. The net production of fish in T3 (5,430.64 kg/ha) was significantly higher (P<0.05) than those of T2 (4,584.70 kg/ha) and T1 (3,562.89 kg/ha). Significantly highest net return (Tk. 68,533.54/ha with benefit cost ratio of 1.36) was achieved from T3 followed by T2 (Tk. 40,080.56/ha with benefit cost ratio of 1.22) and T1 (Tk. 13,786.67/ha with benefit cost ratio of 1.08). The present research findings suggest that an increase of feeding frequency has positive effect on growth and production of pangasiid catfish and silver carp.
Models for Evolution of Dusty Galaxies and E/S0s Seen in Multiband Surveys
Creators: name: Xu, C. K.
name: Lonsdale, C. J.
name: Shupe, D. L.
name: Franceschini, A.
name: Martin, C.
name: Schiminovich, D.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Phenomenological models for evolution of dusty galaxies and E/S0 galaxies, respectively, are developed to address two major questions concenring galaxy populations in deep infrared (IR) surveys: (1) Do normal late-type galaxies or starburst galaxies (including galaxies with obscured AGNs) dominate among sources in deep IR surveys? (2) How much do E/S0 galaxies contribute to the counts in deep mid-infrared (MIR: 3 -- 20$μm$) surveys? Among three new models for evolution of dusty galaxies, it is assumed in Model S1 that starburst galaxies are the dominant population, and in Model S2 that normal galaxies dominate. Model S3 is an intermediate model. Comparing the model predictions with a wide range of observational data collected from the literature, we find that none of these models can be ruled out, given the uncertainties of the data. We show that the most direct method to distinguish these models is to compare the predicted color distributions of IR galaxies with observations, which will soon be available from the SWIRE survey. The models for E/S0 galaxies follow a simple passive evolution approach. Among the three E/S0 models (E1, E2 and E3) investigated in this paper, Model E2 which is specified by a peak formation redshift $z_{peak}=2$, and an e-folding formation time scale $ω=2$ Gyr, fits the data best. This suggests a synchronization between the evolution of E/S0 galaxies and of starburst galaxies, in the sense that the peak of the formation function of E/S0s ($z_{peak}=2$) is close to the peak of the evolution functions of starburst galaxies ($z_{peak} = 1.4$). New predictions for counts and confusion limits in the SIRTF bands are presented.
description: 48 pages text, 24 figures. Accepted by ApJ. A PS file including all figures can be found in http://spider.ipac.caltech.edu/staff/cxu/preprints/apj_paper2.ps.gz
Large deviations of the free energy in the p-spin glass spherical model
Creators: name: Pastore, Mauro
name: Di Gioacchino, Andrea
name: Rotondo, Pietro
Publisher: name: arXiv
Year: 2019
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We investigate the behavior of the rare fluctuations of the free energy in the p-spin spherical model, evaluating the corresponding rate function via the Gärtner-Ellis theorem. This approach requires the knowledge of the analytic continuation of the disorder-averaged replicated partition function to arbitrary real number of replicas. In zero external magnetic field, we show via a one-step replica symmetry breaking (1RSB) calculation that the rate function is infinite for fluctuations of the free energy above its typical value, corresponding to an anomalous, super-extensive suppression of rare fluctuations. We extend this calculation to non-zero magnetic field, showing that in this case this very large deviation disappears and we try to motivate this finding in light of a geometrical interpretation of the scaled cumulant generating function.
description: 17 pages, 4 figures, better graphics
Correlated timing and spectral behavior of 4U 1705-44
Creators: name: Olive, J. -F.
name: Barret, D.
name: Gierlinski, M.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We follow the timing properties of the neutron star low-mass X-ray binary system 4U 1705-44 in different spectral states, as monitored by the Rossi X-ray Timing Explorer over about a month. We fit the power density spectra using multiple Lorentzians. We show that the characteristic frequencies of these Lorentzians, when properly identified, fit within the correlations previously reported. The time evolution of these frequencies and their relation with the parameters of the energy spectra reported in Barret & Olive (2002) are used to constrain the accretion geometry changes. The spectral data were fitted by the sum of a blackbody and a Comptonized component and were interpreted in the framework of a truncated accretion disk geometry, with a varying truncation radius. If one assumes that the characteristic frequencies of the Lorentzians are some measure of this truncation radius, as in most theoretical models, then the timing data presented here strengthen the above interpretation. The soft to hard and hard to soft transitions are clearly associated with the disk receding from and approaching the neutron star respectively. During the transitions, correlations are found between the Lorentzian frequencies and the flux and temperature of the blackbody, which is thus likely to be coming from the disk. On the other hand, in the hard state, the characteristic Lorentzians frequencies which are at the lowest, remained nearly constant despite significant evolution of the spectra parameters. The disk no longer contributes to the X-ray emission, and the blackbody is now likely to be emitted by the neutron star surface which is providing the seed photons for the Comptonization.
description: 20 pages, 8 figures, 2 tables, to appear in the Astrophysical Journal (see also astro-ph/0205184)
Marine Ecosystems and Climate Change: Economic Issues
Creators: name: Tisdell, Clem
name: Tisdell, Clem
Publisher: name: Unknown
Year: 2015
Subjects: subject: Environmental Economics and Policy
subject: climate change
subject: climate adjustment strategies
subject: climate mitigation strategies
subject: coral reefs
subject: economic valuation
subject: ecosystem services
subject: marine ecosystems.

description: Marine ecosystems, and the services they provide, are predicted to alter considerably as a result of climate change. This paper outlines important expected alterations in these ecosystems, considers their economic consequences, and examines economic policies that may be adopted in response to these changes. In doing so, it focuses on two main cases, namely findings about the impact of ocean acidification (and climate change generally) on the Norwegian fisheries and predictions about alterations in coral reef systems. A number of theoretical issues are raised. These include the possibility that if economic impact analysis is used to measure economic value, the global economic value of coral reefs could rise as their area is reduced. This, however, is not necessarily an appropriate measure of economic value, even though it is often used for this purpose. Also the importance of taking into account the opportunity costs involved in conserving marine ecosystems is stressed. Furthermore, several dynamic aspects of variations in marine ecosystems are shown to be important for valuation purposes as well as for economic policy. Both the economics of mitigation and adjustment policies are discussed. Optimal economic policies for responding to climate change are shown to be sensitive to the dynamics of ecosystem change and are likely to vary regionally.
Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids
Creators: name: Azharuddin, Mohammad
name: Roberg, Karin
name: Dhara, Ashis Kumar
name: Jain, Mayur Vilas
name: Darcy, Padraig
name: Hinkula, Jorma
name: Slater, Nigel K. H.
name: Patra, Hirak K.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/67/70
/692/699/67/70
/13
/13/106
/14/63
/123
/13/31
/96/47
article

description: Funder: MIIC PDF and MIIC seeding grant
description: Funder: The Swedish Cancer Society (2017/301), the County Council of Östergötland, and the Research Funds of Linköping University Hospital
description: Abstract: One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful treatment. One of the ways cancer cells achieve drug resistance is through the expression of efflux pumps that actively pump drugs out of the cells. To date, several studies have investigated the potential of using 3-dimensional (3D) multicellular tumor spheroids (MCSs) to assess drug resistance; however, a unified system that uses MCSs to differentiate between multi drug resistance (MDR) and non-MDR cells does not yet exist. In the present report we describe MCSs obtained from post-diagnosed, pre-treated patient-derived (PTPD) cell lines from head and neck squamous cancer cells (HNSCC) that often develop resistance to therapy. We employed an integrated approach combining response to clinical drugs and screening cytotoxicity, monitoring real-time drug uptake, and assessing transporter activity using flow cytometry in the presence and absence of their respective specific inhibitors. The report shows a comparative response to MDR, drug efflux capability and reactive oxygen species (ROS) activity to assess the resistance profile of PTPD MCSs and two-dimensional (2D) monolayer cultures of the same set of cell lines. We show that MCSs provide a robust and reliable in vitro model to evaluate clinical relevance. Our proposed strategy can also be clinically applicable for profiling drug resistance in cancers with unknown resistance profiles, which consequently can indicate benefit from downstream therapy.
Two Gap State Density in MgB$_{2}$: A True Bulk Property or A Proximity Effect?
Creators: name: Giubileo, F.
name: Roditchev, D.
name: Sacks, W.
name: Lamy, R.
name: Thanh, D. X.
name: Klein, J.
name: Miraglia, S.
name: Fruchart, D.
name: Marcus, J.
name: Monod, Ph.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on the temperature dependence of the quasiparticle density of states (DOS) in the simple binary compound MgB2 directly measured using scanning tunneling microscope (STM). To achieve high quality tunneling conditions, a small crystal of MgB2 is used as a tip in the STM experiment. The ``sample'' is chosen to be a 2H-NbSe2 single crystal presenting an atomically flat surface. At low temperature the tunneling conductance spectra show a gap at the Fermi energy followed by two well-pronounced conductance peaks on each side. They appear at voltages V$_{S}\simeq \pm 3.8$ mV and V$_{L}\simeq \pm 7.8$ mV. With rising temperature both peaks disappear at the Tc of the bulk MgB2, a behavior consistent with the model of two-gap superconductivity. The explanation of the double-peak structure in terms of a particular proximity effect is also discussed.
description: 4 pages, 3 figures
Contrasting the collective social value of outdoor recreation and the substitutability of nature areas using hot spot mapping
Creators: name: DE VALCK, Jeremy
name: BROEKX, Steven
name: LIEKENS, Inge
name: DE NOCKER, Leo
name: VAN ORSHOVEN, Jos
name: VRANKEN, Liesbet
name: DE VALCK, Jeremy
name: BROEKX, Steven
name: LIEKENS, Inge
name: DE NOCKER, Leo
name: VAN ORSHOVEN, Jos
name: VRANKEN, Liesbet
Publisher: name: Unknown
Year: 2015
Subjects: subject: Community/Rural/Urban Development
subject: Land Economics/Use
subject: Public Economics
subject: Resource /Energy Economics and Policy
subject: Cultural ecosystem services
subject: Hot spot analysis
subject: Nature valuation
subject: Outdoor recreation
subject: Public Participation GIS
subject: Substitute

description: This paper investigates one specific cultural ecosystem service: outdoor recreation. We present a methodology to map the collective social value of outdoor recreation and identify the substitutability among nature sites within a specific spatial context. This methodology is applied to the province of Antwerp, Belgium. We propose an indicator of substitutability among nature areas, contrasting unique but poorly substitutable sites (hot spots) with highly substitutable sites (cold spots). Using a combination of survey information, public participation GIS (PPGIS) and kernel density mapping, we produce density surfaces representing the distribution of the collective social value attributed to outdoor recreation. We also compute Getis-Ord Gi* spatial statistics to identify local outdoor recreation clusters. In addition, we explore how recreational behaviour affects substitutability. Our results suggest a duality between the social value of outdoor recreation and the level of substitutability among nature sites. Highly substitutable sites tend to be found near areas of higher population density, which are as well sites of higher social value. Individual-specific parameters such as the type of recreational activity appear to substantially modify substitutability patterns among nature sites. We conclude by discussing the methodological and policy-related implications of this research.
description: An updated version of this working paper is published as: De Valck J., J., Broekx, S., Liekens, I., De Nocker, L., Van Orshoven, J., Vranken, L. (2016). Contrasting collective preferences for outdoor recreation and substitutability of nature areas using hot spot mapping. Landscape and Urban Planning, 151, 64-78.
Analysing the evolution of aerospace ecosystem development
Creators: name: Jose, Luna A.
name: Brintrup, Alexandra
name: Salonitis, Konstantinos
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Ecology and environmental sciences
subject: Computer and information sciences
subject: FOS: Computer and information sciences
subject: Engineering and technology
subject: FOS: Engineering and technology

description: Aerospace manufacturing industry is predicted to continue growing. Rising demand is triggering the current global aerospace ecosystem to evolve and adapt to challenges never faced before. New players into the aerospace manufacturing industry and the development of new ecosystems are evidencing its evolution. Understanding how the aerospace ecosystem has evolved is thus essential to prepare optimal conditions to nurture its growth. Recent studies have successfully combined economics and network science methods to map, analyse and predict the evolution of industrial ecosystems. In comparison to previous studies which apply network science-based methodologies to macro-economic research, this paper uses these methods to analyse the evolution of a particular industrial ecosystem, namely the aerospace sector. In particular, we develop bipartite country-product networks based on trade data over 25 years, to identify patterns and similarities in the evolution of developed aerospace manufacturing countries ecosystems. The analysis is elaborated at a macroscopic (network) and microscopic (nodes) levels. Motivated by studies in ecological networks, we use nestedness analysis to find patterns depicting the distribution and evolution of exported products across ecosystems. Our analysis reveals that developed ecosystems tend to become more analogous, as countries lean towards having a revealed comparative advantage (RCA) in the same group of products. Countries also tend to become more nested in their aerospace product space as they start developing a higher RCA. It is revealed that although countries develop an advantage on unique products, they also tend to increase competition with each other. Further analysis shows that manufactured products have a stronger correlation to an aerospace ecosystem than primary products; and in particular, the automotive sector shows the highest correlation with positive aerospace sector evolution. Competition between countries with well-developed aerospace ecosystems tends to centre on automotive parts, general industrial machinery, power generating machinery and equipment, and chemical materials and products.
Efficient evaluation of AGP reduced density matrices
Creators: name: Khamoshi, Armin
name: Henderson, Thomas
name: Scuseria, Gustavo
Publisher: name: arXiv
Year: 2019
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose and implement an algorithm to calculate the norm and reduced density matrices of the antisymmetrized geminal power (AGP) of any rank with polynomial cost. Our method scales quadratically per element of the reduced density matrices. Numerical tests indicate that our method is very fast and capable of treating systems with a few thousand orbitals and hundreds of electrons reliably in double-precision. In addition, we present reconstruction formulae that allows one to decompose higher order reduced density matrices in terms of linear combinations of lower order ones, thereby reducing the computational cost significantly.
Manejo da Via Aérea Difícil: Estratégias e Novas Tecnologias
Creators: name: Rafaella Morais Santana, Rafaella Morais Santana
name: João Guilherme Couto Alves, João Guilherme Couto Alves
name: Glaucie Samara Pinto Pereira, Glaucie Samara Pinto Pereira
name: Letícia Fernandes dos Santos, Letícia Fernandes dos Santos
name: Thamirys Lorrayne dos Santos Quintanilha, Thamirys Lorrayne dos Santos Quintanilha
name: Eduardo Scutti Garbugio, Eduardo Scutti Garbugio
name: Marcela Caixeta da Cunha Rocha, Marcela Caixeta da Cunha Rocha
name: Fernanda Faustina Pereira, Fernanda Faustina Pereira
name: Letícia Fernandes dos Santos, Letícia Fernandes dos Santos
name: Yasmin Lucena de Castro, Yasmin Lucena de Castro
name: Lara Christina Rangel Braga, Lara Christina Rangel Braga
name: Brunna Ferreira Fabio, Brunna Ferreira Fabio
name: Larissa Silva Ferreira, Larissa Silva Ferreira
name: Josiany Soares Fernandes, Josiany Soares Fernandes
name: Gabrielle Vilela Actis Cezar, Gabrielle Vilela Actis Cezar
name: Gabriel Ragone de Oliveira Martins, Gabriel Ragone de Oliveira Martins
name: Talita Carvalho Cordeiro, Talita Carvalho Cordeiro
Publisher: name: Zenodo
Year: 2025

description: O manejo da via aérea é um componente crítico em ambientes de emergência e anestesia. A identificação e o manejo de vias aéreas difíceis são desafios significativos que podem levar a complicações graves e até mesmo à morte. Novas técnicas e tecnologias têm evoluído para otimizar a intubação e a ventilação em paciente com via aérea difícil. A via aérea difícil refere-se a situações em que a intubação endotraqueal ou a ventilação com bolsa-máscara é desafiadora ou impossível. A classificação da via aérea difícil é comumente baseada em fatores anatômicos, fatores relacionados ao paciente e técnicas de intubação. Entre os avanços tecnológicos, destacam- se os videolaringoscópios, que melhoram a visualização e aumentam as taxas de sucesso na intubação, especialmente em anatomias desafiadoras, e os dispositivos supraglóticos de segunda geração, que oferecem alternativas eficazes para ventilação em casos de falha de intubação. A intubação guiada por broncoscopia é reconhecida como padrão-ouro em situações específicas, embora dependa de habilidades técnicas avançadas. Aprimorando técnicas como posicionamento adequado do paciente, uso de dispositivos adicionais como selas de bolsa, e ajuste da pressão para garantir uma ventilação eficaz. A aplicação sistemática de algoritmos é enfatizada como uma prática que reduz o tempo de intervenção e melhora os resultados, sendo reforçada pelo treinamento em simulação, que prepara as equipes para cenários reais sob alta pressão. Técnicas invasivas, como cricotireoidostomia, são opções de último recurso, com desafios associados à sua execução segura. Além das habilidades técnicas, o artigo destaca a importância da comunicação eficaz e do trabalho em equipe no manejo bem-sucedido de casos complexos. Conclui-se que, apesar dos avanços, a variabilidade clínica e a imprevisibilidade da via aérea difícil exigem treinamento contínuo, integração de novas tecnologias e aplicação de práticas sistematizadas para reduzir riscos e melhorar os desfechos.
Kovacs Effect in Glass with Material Memory Revealed in Non-Equilibrium Particle Interactions
Creators: name: Lulli, Matteo
name: Lee, Chun-Shing
name: Zhang, Ling-Han
name: Deng, Hai-Yao
name: Lam, Chi-Hang
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The Kovacs effect is a remarkable feature of the ageing dynamics of glass forming liquids near the glass transition temperature. It consists in a non-monotonous evolution of the volume/enthalpy after a succession of two abrupt temperature changes: first from a high initial temperature $T_i$ to a much lower annealing temperature $T_a$ followed by a smaller second jump back to a slightly higher final temperature $T_f$. The second change is performed when the instantaneous value of the volume/enthalpy coincides with the equilibrium one at the final temperature. While this protocol might be expected to yield equilibrium dynamics right after the second temperature change, one observes the so-called Kovacs hump in glassy systems. In this paper we apply such thermal protocol to the Distinguishable Particles Lattice Model (DPLM) for a wide range of fragility of the system. We study the Kovacs hump based on energy relaxation and all main experimental features are captured. Results are compared to general predictions based on a master equation approach in the linear response limit. We trace the origin of the Kovacs hump to the non-equilibrium nature of the probability distribution of particle interaction energies after the annealing and find that its difference with respect to the final equilibrium distribution is non-vanishing with two isolated zeros. This allows Kovacs' condition of equilibrium total energy to be met out-of-equilibrium, thus representing the memory content of the system. Furthermore, the hump is taller and occurs at a larger overlap with the system initial configuration for more fragile systems. The dynamics of a structural temperature for the mobile regions strongly depends on the glass fragility while for the immobile ones only a weak dependence is found.
description: 9 pages, 9 figures: Added fragility study and encoding of the memory in the particles interaction energy distribution; added doi
Should $E_8$ SUSY Yang-Mills be Reconsidered as a Family Unification Model?
Creators: name: Adler, Stephen L.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review earlier proposals for $E_8$ family unification, and discuss why recent work of Kovner and Shifman on condensates in supersymmetric Yang-Mills theories suggests the reconsideration of $E_8$ supersymmetric Yang-Mills as a family unification theory.
description: TeX 16p
Cumulants of the three state Potts model and of nonequilibrium models with C3v symmetry
Creators: name: Tome, Tania
name: Petri, Alberto
Publisher: name: arXiv
Year: 2002
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The critical behavior of two-dimensional stochastic lattice gas models with C3v symmetry is analyzed. We study the cumulants of the order parameter for the three state (equilibrium) Potts model and for two irreversible models whose dynamic rules are invariant under the symmetry operations of the point group C3v. By means of extensive numerical analysis of the phase transition we show that irreversibility does not affect the critical behavior of the systems. In particular we find that the Binder reduced fourth order cumulant takes a universal value U* which is the same for the three state Potts model and for the irreversible models. The same universal behavior is observed for the reduced third-order cumulant.
description: gzipped tar file containing: 1 latex file + 6 eps figures
Paragiopagurus boletifer
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Parapaguridae
Paragiopagurus
Paragiopagurus boletifer

description: Paragiopagurus boletifer (de Saint Laurent, 1972)
 Parapagurus boletifer (de Saint Laurent, 1972): 110, figs. 5, 20 [type locality: Japan; holotype MNHP Pg.2230]. Hawaiian Is. record: Paragiopagurus boletifer (de Saint Laurent, 1972) — Lemaitre 1996: 218 [H.I.; detailed information on records in Lemaitre in prep.].
 Taxonomy: Lemaitre (1996)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Subtidal to bathyal, 85–419 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on pages 29-30, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
Are Gasoline Demand Elasticities Different across Cities?
Creators: name: Barla, Philippe
name: Herrmann, Markus
name: Ordas-Criado, Carlos
name: Miranda-Moreno, Luis F.
name: Barla, Philippe
name: Herrmann, Markus
name: Ordas-Criado, Carlos
name: Miranda-Moreno, Luis F.
Publisher: name: Unknown
Year: 2015
Subjects: subject: Environmental Economics and Policy
subject: Gasoline demand
subject: price and income elasticities
subject: random coefficient model
subject: peak car hypothesis

description: In this paper, we examine the heterogeneity in gasoline demand price and income elasticities across 40 cities in the province of Quebec Canada using quarterly data over the 2004 to 2009 period. We reject the hypothesis of identical elasticities across markets. However, the range of values for the price elasticity, between -0.65 and -0.14, is relatively narrow and confirms that the demand for gasoline is price inelastic. We find evidence that the average price and income elasticity is somewhat larger in markets with public transportation. Furthermore, these markets experience a strong declining trend in gasoline use per capita.
Paragiopagurus pacificus
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Parapaguridae
Paragiopagurus
Paragiopagurus pacificus

description: Paragiopagurus pacificus (Edmondson, 1925)
 Sympagurus pacificus Edmondson, 1925: 28, fig. 5, pl. 2, fig. C [type locality: Laysan; holotype: BPBM S1816].
 Remarks. Described from the Hawaiian Is. but no subsequent records are known from the archipelago.
 Additional Hawaiian Is. reference:
 Sympagurus pacificus Edmondson, 1925 — de Saint Laurent 1972: 109 [holotype].
 Taxonomy. de Saint Laurent (1972)
 Geographical distribution. Only known from the Hawaiian Is.
 Habitat. Subtidal to bathyal, 109–366 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 30, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
REVALUATION OF WOMEN'S WORK IN BANGLADESH
Creators: name: Chowdhury, Nuimuddin
name: Chowdhury, Nuimuddin
Publisher: name: Unknown
Year: 1986
Subjects: Research and Development/Tech Change/Emerging Technologies

description: The paper seeks to revalue women's nonmarket work in the context of parts of rural Bangladesh, v} ich is where most of her women folk live. It raises relevant conceptual and methodological considerations relating to revaluation of women's work, reviews various sets of evidence on the pattern of time use of women in Bangladesh, and then puts up a broad order of magnitude as to the value of women's nonmarket work. For this purpose, it taken the sexual division of labour and sexual differential in rates of wages as given. The paper shows that rural women in Bangladesh work as hard, if anything harder, as mm on a daily basis. It also shows the widespread sexual distribution of labour in the sense of involving the influence of social stereotypes in the allocation of tasks between males and females. Finally, it shows that productive work within households consists of market work, typically by men, and a good deal of subsistence work and domestic work performed by women.