cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Subliminal Stimuli Generated in Films through Successive Frames: A Quantitative Assessment
Creators: name: Sanz-Aznar, Javier
name: José Caballero-Molina, Juan
name: Tarragó-Mussons, Anna
name: Rey-Benito, Endika
name: Consuegra-Fernandez, Marta
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 520406
subject: Sensory processes, perception and performance

description: Although numerous theoretical references have been made to subliminal stimuli in filmmaking, no quantitative studies to date have sought to specify their temporal limits. Since the 1920s, several filmmakers have aimed to elicit an emotional impact on the viewer through the inclusion of isolated frames, which supposes the minimum possible temporal extension in films. Through two experiments, this study analysed the threshold between subliminal and supraliminal stimuli in films containing potential subliminal stimuli comprising one to four frames, played at frame rates of 25, 30, and 60 frames per second. The first experiment involved asking participants to view a film excerpt, including these stimuli, and then answer a survey. The second required participants to identify potentially subliminal stimuli whilst viewing a film clip. The stimuli analysed could not be defined as subliminal for 100% of viewers for any number of frames per frame rate, but were predominantly unidentified for one-frame stimuli in films played at 24 or 30 frames per second, and one- to three-frame stimuli in films played at 60 frames per second. Furthermore, three- and four-frame stimuli at 24 and 30 frames per second were found to be supraliminal, whilst the results for two-frame stimuli played at 24 or 30 and four-frame stimuli played at 60 frames per second were inconclusive. Future research is needed to analyse the effect of the nature of the image used as a stimulus and its location within a shot or in a cut between shots.
“Now I like to know what I smoke”—differentiated cannabis normalization in Polish online discussions
Creators: name: Wanke, Michał
name: Załęska, Olga
name: Siuda, Piotr
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Developmental Biology
subject: Mental Health

description: This study explores how cannabis has been accommodated over the last 18 years in the social world of an online forum in Poland. It considers users who operate in the context of unhurried normalization and restrictive policy that has barely changed over the last two decades. Simultaneously, these users refer to global cannabis cultures and follow progressive policy developments worldwide. Cannabis-related threads were scrapped from the biggest Polish forum, posted in the years 2006–2023, and divided into three periods marked by minor relaxation of the punitive law in 2011 and the introduction of medical cannabis in 2019. The threads were thematically analyzed to track changes in the perceived access to cannabis and shifts in the reasons users praise it. The shifts indicate the interaction of the normalization processes on both sides of the cannabis social world in Poland: among users and in society. The praise becomes less unconditional, and nuanced goals, or reflexivity of use emerges. We have recognized a consensus among forum users that there are problems associated with use. Instead of harm being neutralized as it used to be when stigmatization mattered more, it is now discussed among users who are becoming better informed, reflexive, and likely to engage with bottom-up harm reduction efforts.
Manganese Accumulation and Tissue-level Distribution in the Australian Hyperaccumulator Gossia Bidwillii (Myrtaceae)
Creators: name: Abubakari, F
name: Nkrumah, PN
name: Fernando, Denise
name: Erskine, PD
name: Echevarria, G
name: van der Ent, A
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310899
subject: Plant biology not elsewhere classified

description: The manganese (Mn) hyperaccumulator Gossia bidwillii is a tree species native to subtropical eastern Australia where it occurs on Mn-rich soils. Here, we conducted the first Mn accumulation and tissue-level distribution study on wild and experimentally grown G. bidwillii. Gossia bidwillii plants were subjected to different levels of Mn (250 µg g−1, 500 µg g−1, 1000 µg g−1) soil dosing treatments, whereas the wild G. bidwillii was sampled from growing on highly Mn-enriched natural soils. We used laboratory-based micro-X-ray Fluorescence (µXRF) elemental mapping to elucidate in situ distribution patterns of Mn and other elements in hydrated wild and Mn-dosed G. bidwillii leaves. The data from wild G. bidwillii revealed that it can be strongly Mn-hyperaccumulating with foliar Mn concentrations of 39 000 µg g−1 and 24 000 µg g−1 in old and young leaves, respectively. In the Mn dosing trial, G. bidwillii accumulated 24 400 µg g−1 in old leaves and 17 100 µg g−1 in young leaves in the highest treatment level. The laboratory based µXRF data revealed that Mn is uniformly enriched throughout the laminae and petioles of both young and old leaves in wild G. bidwillii; while in Mn-dosed G. bidwillii, the foliar Mn distribution was primarily concentrated at the leaf-tip and lamina. The approach employed by combining data from the field and controlled experiments was especially meaningful for investigating Mn accumulation in this species and gaining added insight into the phenomenon of Mn hyperaccumulation.
Additional file 1 of Real-world evidence on the economic implications of CGRP-mAbs as preventive treatment of migraine
Creators: name: Siersbæk, Nikolaj
name: Kilsdal, Lærke
name: Jervelund, Christian
name: Antic, Sonja
name: Bendtsen, Lars
Publisher: name: figshare
Year: 2024
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology
subject: Computational Biology

description: Supplementary Material 1
Is start time a risk factor for amounts consumed on a given day if drinking duration is taken into account? An event-level study
Creators: name: Anderson-Luxford, Dan
name: Callinan, Sarah
name: Kuntsche, Emmanuel
name: Willoughby, Bree
name: Mojica-Perez, Yvette
name: Wilkinson, Claire
name: Kowalski, Michala
name: Ritter, Alison
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study investigates the impact of COVID-19 restrictions on typical drinking patterns and the relationship between drinking start time and duration on daily drinks and drinking pace. 573 participants from New South Wales (NSW), Australia completed five waves of weekly diaries assessing a ‘typical week’s alcohol consumption’ between March and November 2020. We examined the impact of COVID-19 restrictions on drinking start time, duration and pattern. Multilevel regression and mediation models were then conducted to ascertain the associations between start time and duration on the quantity and pace of drinking. Participants started drinking significantly earlier in the day during lockdown compared to pre-lockdown. The earlier drinking started on a given day the higher the number of drinks consumed that day. Earlier start times led to increased consumption indirectly, via increased duration. After adjusting for duration, later start times were associated with increased consumption. The daily drinking pace also increased significantly with later start times. Our study demonstrates that start time is a risk factor for heavier alcohol consumption, but only because it leads to increased drinking duration. Later start times are associated with increased drinking pace, and after adjusting for duration, lead to higher daily drinking volumes.
Reported patient experiences of extended-release buprenorphine for opioid dependence: a qualitative systematic review and thematic analysis
Creators: name: Flam-Ross, Juliet Miko
name: Zampini, Giulia Federica
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Pharmacology
Cancer
Science Policy
Mental Health

description: There is a growing opioid overdose crisis internationally. One evidence-based solution is a newly available form of opioid substitution treatment: extended-release buprenorphine (XR-BUP). The following study aims to systematically review the qualitative evidence of reported patient experiences of XR-BUP. We conducted a systematic review to synthesize qualitative literature on patient experiences of XR-BUP. In June 2023, we searched five databases. Articles were screened using clearly defined inclusion and exclusion criteria. Critical appraisal and thematic analysis using stigma as an organizing concept were carried out. We screened 581 titles and abstracts and selected 13 articles. We identified six key themes: 1) living a normal life 2) Being perceived as a “drug user”; 3) physiological effects of the drug; 4) investments (time and money); 5) life goals; and 6) the luxury of time. Our review elevates XR-BUP as a powerful technology for the reduction of stigma. However, patient agency and autonomy should be at the forefront of decision-making around treatment options. Providers of treatment for opioid dependence can use this study alongside local context to consider the introduction or expansion of treatment with XR-BUP.
Additional file 1 of Design of the Building Research in CRC prevention (BRIDGE-CRC) trial: a 6-month, parallel group Mediterranean diet and weight loss randomized controlled lifestyle intervention targeting the bile acid-gut microbiome axis to reduce colorectal cancer risk among African American/Black adults with obesity
Creators: name: McLeod, Andrew
name: Wolf, Patricia
name: Chapkin, Robert S.
name: Davidson, Laurie A.
name: Ivanov, Ivan
name: Berbaum, Michael
name: Williams, Lauren R.
name: Gaskins, H. Rex
name: Ridlon, Jason
name: Sanchez-Flack, Jen
name: Blumstein, Lara
name: Schiffer, Linda
name: Hamm, Alyshia
name: Cares, Kate
name: Antonic, Mirjana
name: Bernabe, Beatriz Penalver
name: Fitzgibbon, Marian
name: Tussing-Humphreys, Lisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. SPIRIT checklist.
A Novel Floating High-Voltage Level Shifter with Pre-Storage Technique
Creators: name: Li, Q
name: Yang, Y
name: Ma, H
name: Zhou, Y
name: You, G
name: Zhang, M
name: Xiang, Wei
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 460699
subject: Distributed computing and systems software not elsewhere classified

description: This paper proposes a novel floating high-voltage level shifter (FHV-LS) with the pre-storage technique for high speed and low deviation in propagation delay. With this technology, the transmission paths from input to output are optimized, and thus the propagation delay of the proposed FHV-LS is reduced to as low as the sub-nanosecond scale. To further reduce the propagation delay, a pull-up network with regulated strength is introduced to reduce the fall time, which is a crucial part of the propagation delay. In addition, a pseudosymmetrical input pair is used to improve the symmetry of FHV-LS structurally to balance between the rising and falling propagation delays. Moreover, a start-up circuit is developed to initialize the output state of FHV-LS during the VDDH power up. The proposed FHV-LS is implemented using 0.3-µm HVCMOS technology. Post-layout simulation shows that the propagation delays and energy per transition of the proposed FHV-LS are 384 ps and 77.7 pJ @VH = 5 V, respectively. Finally, the 500-points Monte Carlo are performed to verify the performance and the stability.
The highs and lows of cannabis stigma: a vignette study of factors that influence stigma toward cannabis consumers
Creators: name: Coles, Ashlee R. L.
name: Harris, Nick
name: Bishop, Lisa D.
name: Howells, Rachel L.
name: Donnan, Jennifer R.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Cannabis consumption has increased across all demographics following legalization in Canada. While cannabis is becoming increasingly more prevalent, prevailing stigma in the community has been highlighted as a concern. The purpose of this study was to determine the context in which Canadians stigmatize cannabis use to inform policy and harm-reduction campaigns. An experimental vignette design aimed to quantify cannabis-related stigma and explore the impact of the following items on stigma (1) reason for use (recreational/medical/self-medication); (2) method of consumption (smoking joints/edibles); (3) frequency (monthly/almost daily/multiple times daily); and (4) source (unregulated/regulated market). Canadian citizens 18 years and older were recruited through public opinion agency (N = 1118). Participants were randomly assigned two vignettes altering the independent variables and completed the Social Distance Questionnaire following each vignette as the dependent measure of stigma. 2x3 ANOVAs revealed that stigma toward cannabis consumption increased when cannabis was used recreationally, by smoking joints, more frequently, and purchased from the neighborhood. Stigma may be a barrier to help-seeking for consumers who use riskier methods of administration. Stigmatization may also impact purchasing from regulated suppliers. Findings can help inform cannabis policies and education strategies to reduce stigma and barriers regarding consumption behaviors.
Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly
Creators: name: Formosa, LE
name: Maghool, S
name: Sharpe, AJ
name: Reljic, B
name: Muellner-Wong, L
name: Stroud, DA
name: Ryan, MT
name: Maher, Megan
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Cytochrome c oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome c oxidase). Although mutations in COA7 have been linked to complex IV assembly defects and neurological conditions such as peripheral neuropathy, ataxia, and leukoencephalopathy, the precise role COA7 plays in the biogenesis of complex IV is not known. Here, we show that loss of COA7 blocks complex IV assembly after the initial step where the COX1 module is built, progression from which requires the incorporation of copper and addition of the COX2 and COX3 modules. The crystal structure of COA7, determined to 2.4 Å resolution, reveals a banana-shaped molecule composed of five helix-turn-helix (α/α) repeats, tethered by disulfide bonds. COA7 interacts transiently with the copper metallochaperones SCO1 and SCO2 and catalyzes the reduction of disulfide bonds within these proteins, which are crucial for copper relay to COX2. COA7 binds heme with micromolar affinity, through axial ligation to the central iron atom by histidine and methionine residues. We therefore propose that COA7 is a heme-binding disulfide reductase for regenerating the copper relay system that underpins complex IV assembly.
Additional file 1 of The incidence of nosocomial bloodstream infection and urinary tract infection in Australian hospitals before and during the COVID-19 pandemic: an interrupted time series study
Creators: name: Mitchell, Brett G
name: Stewardson, Andrew J
name: Kerr, Lucille
name: Ferguson, John K
name: Curtis, Stephanie
name: Busija, Ljoudmila
name: Lydeamore, Michael J
name: Graham, Kirsty
name: Russo, Philip L
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
Examining a Continuous Glucose Monitoring Plus Online Peer Support Community Intervention to Support Hispanic Adults With Type 2 Diabetes: Protocol for a Mixed Methods Feasibility Study
Creators: name: Ng, Ashley
name: Greenwood, DA
name: Iacob, E
name: Allen, NA
name: Ferrer, M
name: Rodriguez, B
name: Litchman, ML
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 420699
subject: Public health not elsewhere classified

description: Background: Type 2 diabetes is twice as likely to affect Hispanic people than their White counterparts. Technology and social support may be an important part of behavior change. In this study, we address gaps in diabetes care for Hispanic Spanish-speaking people with diabetes through an online peer support community (OPSC) pilot intervention using Hispanic Spanish-speaking peer facilitators with diabetes to enhance the use of continuous glucose monitoring (CGM) for diabetes management. Objective: This study aims to address gaps in diabetes care for Hispanic Spanish-speaking people with diabetes through an OPSC pilot intervention using Hispanic Spanish-speaking peer facilitators with diabetes to enhance the use of CGM for diabetes management. Methods: A mixed-methods, pre-post test design will be used in this feasibility study. A total of 50 Hispanic participants with type 2 diabetes willing to wear a continuous glucose monitor for 13 weeks will be recruited. Hispanic Spanish-speaking peer facilitators with diabetes and experience wearing a continuous glucose monitor will be employed and undergo training. Peer facilitators will help participants learn how CGM data can inform behavior changes via an OPSC. Participants will interact with the private OPSC at least three times a week. Weekly questions and prompts derived from the Association of Diabetes Care and Education Specialists, previously American Association of Diabetes Educators, and seven self-care behaviors will be delivered by peer facilitators to engage participants. Measures of feasibility and acceptability will be determined by the percentage of participants who enroll, complete the study, and use CGM (number of scans) and objective metrics from the OPSC. Efficacy potential outcomes include change in time in range of 70 to 180 mg/dL from baseline to 12 weeks, A1c, diabetes online community engagement, self-efficacy, and quality of life. Additionally, semistructured exit interviews will be conducted. Results: Funding for this project was secured in November 2018 and approved by the institutional review board in April 2019. Peer facilitator recruitment and training were undertaken in the second half of 2019, with participant recruitment and data collection conducted in January and April 2020. The study has now concluded. Conclusions: This study will generate new evidence about the use of an OPSC for Hispanic Spanish-speaking patients with diabetes to make behavior changes incorporating feedback from CGM.
Additional file 4 of Analysis of phase III clinical trials in metastatic NSCLC to assess the correlation between QoL results and survival outcomes
Creators: name: Servetto, Alberto
name: Di Maio, Massimo
name: Salomone, Fabio
name: Napolitano, Fabiana
name: Paratore, Chiara
name: Di Costanzo, Fabrizio
name: Viscardi, Giuseppe
name: Santaniello, Antonio
name: Formisano, Luigi
name: Bianco, Roberto
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Neuroscience
Biotechnology
Cancer
Science Policy

description: Additional file 4: Table S4. Description of QoL results based on results of the trial. The analysis included only the 51 trials in which a non-statistically significant difference in QoL results was found between experimental or control armor with QoL outcomes inferior in the experimental arm. Fisher’s exact test.
What shapes research and research capacity building in rural health services? Context matters
Creators: name: Shee, A Wong
name: Quilliam, C
name: Corboy, D
name: Glenister, K
name: McKinstry, Carol
name: Beauchamp, A
name: Alston, L
name: Maybery, D
name: Aras, D
name: Mc Namara, K
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified
classificationCode: 420305
subject: Health and community services
classificationCode: 441003
subject: Rural sociology

description: Objective: To determine the contextual factors influencing research and research capacity building in rural health settings. Design: Qualitative study using semi-structured telephone interviews to collect data regarding health professionals’ research education and capacity building. Analysis involved inductive coding using Braun and Clark’s thematic analysis; and deductive mapping to the Consolidated Framework for Implementation Research (CFIR). Setting: Victorian rural health services and university campuses. Participants: Twenty senior rural health managers, academics and/or research coordinators. Participants had at least three years’ experience in rural public health, health-related research or health education settings. Main outcome measures: Contextual factors influencing the operationalisation and prioritisation of research capacity building in rural health services. Results: Findings reflected the CFIR domains and constructs: intervention characteristics (relative advantage); outer setting (cosmopolitanism, external policies and incentives); inner setting (implementation climate, readiness for implementation); characteristics of individuals (self-efficacy); and process (planning, engaging). Findings illustrated the implementation context and the complex contextual tensions, which either prevent or enhance research capacity building in rural health services. Conclusions: Realising the Australian Government’s vision for improved health service provision and health outcomes in rural areas requires a strong culture of research and research capacity building in rural health services. Low levels of rural research funding, chronic workforce shortages and the tension between undertaking research and delivering health care, all significantly impact the operationalisation and prioritisation of research capacity building in rural health services. Effective policy and investment addressing these contextual factors is crucial for the success of research capacity building in rural health services.
Isolated absence of the right pulmonary artery with advanced emphysema in the right lung.
Creators: name: Hermie, Isabeau
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Cardiovascular system
subject: Thorax
subject: CT-Angiography
subject: Plain radiographic studies
subject: Diagnostic procedure
subject: Chronic obstructive airways disease
subject: Congenital

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 54 years
description: Clinical History: A 54-year-old women who has to undergo cardiac ablation because of atrial tachycardia presents at our radiology department for a preoperative cardiac CT-scan. Previous history showed recurrent respiratory tract infections. She recently quit smoking (31 pa... Final Diagnosis: Right UAPA with advanced emphysema in the right lung.
Additional file 3 of Analysis of phase III clinical trials in metastatic NSCLC to assess the correlation between QoL results and survival outcomes
Creators: name: Servetto, Alberto
name: Di Maio, Massimo
name: Salomone, Fabio
name: Napolitano, Fabiana
name: Paratore, Chiara
name: Di Costanzo, Fabrizio
name: Viscardi, Giuseppe
name: Santaniello, Antonio
name: Formisano, Luigi
name: Bianco, Roberto
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Neuroscience
Biotechnology
Cancer
Science Policy

description: Additional file 3: Table S3. QoL results in RCTs by target therapies.
Additional file 1 of The Full Value of Vaccine Assessments (FVVA): a framework for assessing and communicating the value of vaccines for investment and introduction decision-making
Creators: name: Hutubessy, Raymond
name: Lauer, Jeremy A.
name: Giersing, Birgitte
name: Sim, So Yoon
name: Jit, Mark
name: Kaslow, David
name: Botwright, Siobhan
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplement 1. Development of the FVVA. Supplement 2. Glossary of abbreviations and definitions.
Theophrastos, Maximinos, Hesychios, Theophilos, and Kleonikos, martyrs of Pedachthoe
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Theophrastos, Maximinos, Hesychios, Theophilos, and Kleonikos, martyrs of Pedachthoe.
Additional file 2 of Analysis of phase III clinical trials in metastatic NSCLC to assess the correlation between QoL results and survival outcomes
Creators: name: Servetto, Alberto
name: Di Maio, Massimo
name: Salomone, Fabio
name: Napolitano, Fabiana
name: Paratore, Chiara
name: Di Costanzo, Fabrizio
name: Viscardi, Giuseppe
name: Santaniello, Antonio
name: Formisano, Luigi
name: Bianco, Roberto
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Neuroscience
Biotechnology
Cancer
Science Policy

description: Additional file 2: Table S2. Distribution of QoL results in RCTs by drug class. We excluded from this analysis 2 trials including combination of chemotherapy plus bevacizumab in the experimental arm, versus chemotherapyalone.
Courtesy stigma toward parents of adolescents with cannabis use disorder: examining the role of language and gender in a Canadian sample
Creators: name: Downey, Molly K.
name: Coles, Ashlee R. L.
name: Harris, Nick
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Plant Biology
subject: FOS: Biological sciences

description: Parents of individuals with substance use disorder (SUD) may be stigmatized by association, known as courtesy stigma. Language may influence SUD stigma, and parents impacted by a child’s SUD have identified the terms ‘enabler’ and ‘codependent’ as stigmatizing. This study examined how language and parent gender influence public perceptions of courtesy stigma toward the parent of an adolescent with cannabis use disorder (CUD). Participants (324 Canadian adults) read a vignette depicting the relationship between a parent and their adolescent child with CUD. The vignette varied by the language describing the parent (deficit-based/neutral) and parent gender (mother/father). Stigma toward the parent was assessed using three Attribution Questionnaire subscales (help/interact, responsibility, and negative emotions). 2 × 2 ANOVAs revealed more willingness to help the father and more negative emotions toward the parent when described using deficit-based language. Perceived responsibility of the parent did not differ by language or parent gender depicted in the vignette. The findings provide preliminary evidence that using deficit-based terminology like ‘enabler’ and ‘codependent’ may contribute to courtesy stigma toward parents of children with SUD. The results highlight the importance of using person-first, neutral language when referring to parents of individuals with SUD.
Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies
Creators: name: Kusuma, GD
name: Li, A
name: Zhu, D
name: McDonald, H
name: Inocencio, IM
name: Chambers, DC
name: Sinclair, K
name: Fang, H
name: Greening, David
name: Frith, JE
name: Lim, R
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines, chemokines, and extracellular vesicles (EVs). Cell-free therapy using EVs is an active and emerging field in regenerative medicine. Typical 2D cultures on tissue culture plastic is far removed from the physiological environment of MSCs. The application of 3D cell culture allows MSCs to adapt to their cellular environment which, in turn, influences their paracrine signalling activity. In this study we evaluated the impact of 3D MSCs culture on EVs secretion, cargo proteome composition, and functional assessment in immunomodulatory, anti-inflammatory and anti-fibrotic properties. MSC-EVs from 2D and 3D cultures expressed classical EV markers CD81, CD63, and CD9 with particle diameter of <100 nm. There were distinct changes in immunomodulatory potencies where 3D cultures exhibited reduced indoleamine 2,3-dioxygenase (IDO) activity and significantly reduced macrophage phagocytosis. Administration of 2D and 3D EVs following double dose bleomycin challenge in aged mice showed a marked increase of bodyweight loss in 3D group throughout days 7–28. Histopathological observations of lung tissues in 3D group showed increased collagen deposition, myofibroblast differentiation and leukocytes infiltrations. Assessment of lung mechanics showed 3D group did not improve lung function and instead exhibited increased resistance and tissue damping. Proteome profiling of MSC-EV composition revealed molecular enrichment of EV markers (compared to parental cells) and differential proteome between EVs from 2D and 3D culture condition associated with immune-based and fibrosis/extracellular matrix/membrane organization associated function. This study provides insight into distinct variation in EV protein composition dependent on the cellular microenvironment of the parental cells, which could have implications in their therapeutic effect and potency. Overall, this work suggests that EVs produced from 3D MSC cultures did not enhance typical MSC-EV properties expected from 2D cultures (immunomodulation, anti-fibrotic, anti-inflammatory). The outcome highlights critical differences between MSC-EVs obtained from different culture microenvironments, which should be considered when scaling up MSC culture for clinical manufacturing.
Parmenius, Elimas and Chrisotelus, priests and martyrs of Babylon and Lucas and Mucus, deacons and martyrs of Babylon
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Parmenius, Elimas and Chrisotelus, priests and martyrs of Babylon and Lucas and Mucus, deacons and martyrs of Babylon.
Identifying innovative approaches to the temporal availability of alcohol in Great Britain—a policy analysis
Creators: name: Cook, Megan
name: Nicholls, James
name: Mitchell, Gemma
name: O’Donnell, Rachel
name: Fitzgerald, Niamh
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: In Great Britain, local authorities responsible for alcohol premises licensing produce a statement of licensing policy setting out how they intend to exercise their statutory licensing functions including on trading hours. We aimed to describe and compare these policies on alcohol trading hours, including their interpretation and application of laws and guidance. Policies were obtained from the websites of all 366 local licensing authorities and uploaded to NVivo. Using content analysis, relevant text was located through manual searching and coded inductively. Many local authorities do not explicitly seek to place controls on trading hours, while others create complex circumstances under which extended hours may be granted. Setting out core or matrix hours is the best example in the findings of local authorities applying their limited discretion to implement the law in ways that suit their needs. Although licensing is ostensibly a policy system devolved to local areas, power remains at the centre in national legislation and guidance. Resultantly, local discretion is highly constrained especially in England/Wales. There is a need to attend to the details of statutory instruments to understand how headline principles and objectives can be made workable in practice for local authorities and boards.
Additional file 1 of MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8
Creators: name: Zhan, Ting
name: Chen, Mengge
name: Liu, Weijie
name: Han, Zheng
name: Zhu, Qingxi
name: Liu, Meng
name: Tan, Jie
name: Liu, Jiaxi
name: Chen, Xiaoli
name: Tian, Xia
name: Huang, Xiaodong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Additional file 1.
Figueiredo, António Manuel e Costa, Carlos S., Do Subdesenvolvimento. Vulgatas, Rupturas e Reconsiderações em torno de um conceito. Roteiro crítico e antologia, Vol. 1: Vulgatas. Edições Afrontamento, 1982, 381 p.
Creators: name: Abreu, Orlando C.
Publisher: name: Economia
Year: 1983

description: Economia, Vol 7 No 2 (1983)
Harnessing the Power of Choice: How to Thrive in a Universe of Entropy
Creators: name: Alzeer, Jawad
Publisher: name: Zenodo
Year: 2024

description: Entropy, a fundamental concept rooted in the second law of thermodynamics, drives the universe towards disorder, influencing energy distribution within systems. This manuscript aims to enhance understanding of entropy's principles and its broad impact across scientific domains, particularly within molecular dynamics and chemical reactions. Through exploration of entropy's role in Gibbs free energy (∆G) and its effects on biological systems like protein folding and aging, we unveil its profound influence on spontaneity in reactions and overall well-being. Highlighting potential energy as a key counterforce to entropy, our findings underscore the significance of informed decision-making in combatting entropy and promoting vitality. By consciously enriching potential energy through lifestyle choices, individuals can mitigate entropy's effects and maintain order within systems, fostering a healthier state and enhancing overall well-being.202
Effect of climatological factors on ground-layer vegetation: a case study to assess and protect the fire-prone grasslands of Odisha, India
Creators: name: Sahoo, Akshaya K.
name: Barik, Kamal L.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Vegetation diversity and the effect of fire on grassland communities in Odisha were evaluated, along with phenological behaviour in response to climatic factors. This study noted 3100 individuals from 63 grassland taxa under 12 families and 44 genera. Of these, 22 grass species and 11 non-grass species were found in burned grassland sites, while 13 grass species and 17 non-grass species were observed in unburned sites. About 81% of the examined individuals flowered in burned sites compared to 35% in unburned sites. The phytosociological investigation reveals that Imperata cylindrica, Cynodon dactylon, Mimosa pudica, and Dichanthium annulatum thrived and showed dominance after a severe fire. Phenological analyses revealed that flower initiation positively correlates with available nitrogen (r = 0.8, p < 0.01) and rainfall (r = 0.6, p < 0.01). However, a negative correlation was found between fruit senescence and soil moisture (r = -0.8, p < 0.01). Principal component analysis revealed that rainfall and available nitrogen are the main factors explaining phenological divergence in sampling sites. This case study on the interaction between phenological data and fire may help to conserve fire-resistant species and develop a conservation strategy for grassland taxa in fire-prone regions.
Effects of service-wide support on regularity of alcohol screening of clients in Australian Aboriginal and Torres Strait Islander Community Controlled Health Services: a cluster randomised trial
Creators: name: Dzidowska, M
name: Raubenheimer, JE
name: Dobbins, TA
name: Lee, Kylie
name: Hayman, N
name: Vnuk, J
name: Haber, P
name: Conigrave, KM
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Background: We have previously shown that service-wide support can increase the odds of alcohol screening in any 2-month period in a cluster randomized trial of service-wide support to Aboriginal and Torres Strait Islander Community Controlled Health Services (ACCHS). Here we report an exploratory analysis on whether the resulting pattern of screening was appropriate. Aim: we assess whether that increase in screening was associated with: (i) increased first-time screening, (ii) increased annual screening, (iii) whether frequently screened clients fell into one of four risk categories as defined by national guidelines. Methods: Setting and participants: 22 ACCHS; randomized to receive the support model in the treatment (‘early-support’) arm over 24-months or to the waitlist control arm. Intervention: eight-component support, including training, sharing of experience, audit-and-feedback and resource support. Analysis: records of clients with visits before and after start of implementation were included. Multilevel logistic modelling was used to compare (i) the odds of previously unscreened clients receiving an AUDIT-C screen, (ii) odds of clients being screened with AUDIT-C at least once annually. We describe the characteristics of a sub-cohort of clients who received four or more screens annually, including if they were in a high-risk category. Results: Of the original trial sample, 43,054 met inclusion criteria, accounting for 81.7% of the screening events in the overall trial. The support did not significantly increase the odds of first-time screening (OR = 1.33, 95% CI 0.81–2.18, p = 0.25) or of annual screening (OR = 0.99, 95% CI 0.42–2.37, p = 0.98). Screening more than once annually occurred in 6240 clients. Of the 841 clients with four or more screens annually, over 50% did not fall into a high-risk category. Females were overrepresented. More males than females fell into high-risk categories. Conclusion: The significant increase in odds of screening observed in the main trial did not translate to significant improvement in first-time or annual screening following implementation of support. This appeared to be due to some clients being screened more frequently than annually, while more than half remained unscreened. Further strategies to improve alcohol screening should focus on appropriate screening regularity as well as overall rates, to ensure clinically useful information about alcohol consumption. Trial Registration ACTRN12618001892202, retrospectively registered 16 November 2018 https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12618001892202.
Disentangling bias for non-destructive insect metabarcoding
Creators: name: Martoni, F
name: Piper, Alexander
name: Rodoni, Brendan
name: Blacket, MJ
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310599
subject: Genetics not elsewhere classified
classificationCode: 410401
subject: Conservation and biodiversity

description: A fast and reliable method for obtaining a species-level identification is a fundamental requirement for a wide range of activities, from plant protection and invasive species management to biodiversity assessments and ecological studies. For insects, novel molecular techniques such as DNA metabarcoding have emerged as a rapid alternative to traditional morphological identification, reducing the dependence on limited taxonomic experts. Until recently, molecular techniques have required a destructive DNA extraction, precluding the possibility of preserving voucher specimens for future studies, or species descriptions. Here we paired insect metabarcoding with two recent non-destructive DNA extraction protocols, to obtain a rapid and high-throughput taxonomic identification of diverse insect taxa while retaining a physical voucher specimen. The aim of this work was to explore how non-destructive extraction protocols impact the semi-quantitative nature of metabarcoding, which alongside species presence/absence also provides a quantitative, but biased, representation of their relative abundances. By using a series of mock communities representing each stage of a typical metabarcoding workflow we were able to determine how different morphological (i.e., insect biomass and exoskeleton hardness) and molecular traits (i.e., primer mismatch and amplicon GC%), interact with different protocol steps to introduce quantitative bias into non-destructive metabarcoding results. We discuss the relevance of taxonomic bias to metabarcoding identification of insects and potential approaches to account for it.
Forest structure but not tree diversity differs among urban woodlands with differing conservation status
Creators: name: Padvaiskas, Erica
name: Richmond, Isabella C
name: Ziter, Carly D
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: While biodiversity conservation in urban areas is a topic of great interest, few studies have focused on the role that urban conservation areas have for preserving biodiversity. Urban woodlands, which are patches of forest habitat confined within the city’s boundaries, offer a promising approach to evaluate the importance of conservation areas within cities. Here, we examined the relationship between conservation status, forest structure and composition across 11 urban woodlands in Montréal, Canada. We used field surveys to assess biodiversity, canopy cover, and structural complexity for urban woodlands with a conservation status and those without. We found that Montréal’s urban woodlands fostered similar levels of biodiversity regardless of conservation status. Similarly, all urban woodlands supported high proportions of native tree species despite differences in conservation status and associated management. Our results suggest that both conservation areas and non-status woodlands play an important role in safeguarding urban biodiversity. Woodlands with a conservation status, however, had higher canopy cover and vegetative complexity, but also contained higher average proportions of invasive trees, particularly Rhamnus cathartica (Common Buckthorn). While the high complexity in vegetation layers observed may provide habitat to native wildlife, these benefits may be limited by the high proportion of invasive trees.
Rotational traction of soccer football shoes on a hybrid reinforced turf system and natural grass
Creators: name: Thompson, Athol
name: Bleakley, C
name: Holmes, W
name: Hodge, E
name: Paul, D
name: Wannop, JW
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 420799
subject: Sports science and exercise not elsewhere classified

description: Traction between a football shoe and the playing surface influences a players’ ability to perform football-specific movements. Too little traction means a player might slip. Too much traction is thought to increase the risk of injury due to foot fixation on the turf. Rotational traction is linked to increased injury risk in football. Elite football is increasingly played on hybrid reinforced natural grass playing surfaces. Our aim is to assess the magnitude of rotational traction of one new hybrid turf system and compare that to a natural grass (control) surface. Nine different Football shoes from three outsole groups (artificial grass, firm ground, soft ground) were loaded onto a portable shoe-surface traction machine to collect rotational traction data on two different playing surfaces (1. Natural Rye grass, 2. A hybrid reinforced turf system) at a single testing session. Peak rotational traction was significantly different across different shoe models (F = 379.8, df = 8, p < 0.0001) and shoe outsole groups (F = 387.4, df = 2, p <.0001). No significant difference was found between the natural grass surface and the hybrid reinforced turf system after considering the minimal detectable change (MDC) of the traction device. Wide-ranging differences in peak rotational traction were found across different individual soccer shoes and outsole groups. The Adidas Nemesis (AG) showed the lowest traction and the Nike Vision (SG) shoe had the highest traction (MD 28.7 N.m; 95% CIs 26.4–30.9; p < 0.0001). The artificial grass (AG) group showed the lowest traction values while the soft ground (SG) group the highest. This objective shoe-surface traction data can help with more informed footwear choices for football played on this type of hybrid playing surface to minimize the risk of lower extremity injury.
Seasonal variations in water use efficiency during the 2022 extreme drought in the Yangtze River Basin: effects of drought timing and severity
Creators: name: Xia, Mingyi
name: Liu, Jiayin
name: Niu, Zhongen
name: Wang, Bin
name: Zeng, Na
name: Lv, Yan
name: Xue, Shuna
name: Liang, Shuang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Water use efficiency (WUE) is critical for understanding the carbon-water coupling of ecosystems, yet its response to extreme droughts remains debated. This study applied the CEVSA-ES model to simulate WUE across the Yangtze River Basin from 2020 to 2022, assessing the effects of extreme drought. The results reveal a significant 12.67% decrease in WUE during summer, while extreme and severe drought areas in autumn experienced an 11% increase in WUE. Seasonal WUE variations were linked to evapotranspiration (ET) and gross primary productivity (GPP): in summer, increased ET led to WUE decline, while reduced ET in areas affected by autumn drought resulted in WUE increase. In contrast, areas with moderate to light drought in autumn saw continued ET increase and WUE decline. These findings suggest that WUE responses to drought depend on drought duration and severity: WUE tends to decline in the early stages of drought and increase in later stages, with the transition timing influenced by drought severity. This study underscores the need to account for the spatiotemporal heterogeneity of drought and its complex regulatory mechanisms on WUE in predicting future climate change effects.
Additional file 1 of Risk factors for mortality in patients with acute exacerbation of cor pulmonale in plateau
Creators: name: Feng, Xiaokai
name: Yang, Chenlu
name: Sun, Zerui
name: Kan, Wanrong
name: He, Xiang
name: Chen, Yongxin
name: Tuo, Yajun
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 1