cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ta'limda innovatsion yangi pedagogik texnologiyalarni qo'llash
Creators: name: Bog'dagul, Sayfiyeva
Publisher: name: Zenodo
Year: 2023
Subjects: metodik tavsiya, o'tmish, pedagogik tavsiya, bilim, ko'nikma, malaka

description: Ushbu metodik tavsiyada yosh avlodga o'tmish va bugungi pedagogik yangiliklarni mukammal o'rgatish hamda ularda bilim, ko'nikma va malakalarni shakllantirish masalalari xususida ma'lumot berilgan. Ushbu ko'rsatma barcha sohalar, xususan, tarix fani bo'yicha tadqiqot olib borayotgan mutaxassislarga, umumiy o'rta ta'lim o'qituvchilari uchun mo'ljallangan.
HUMAN MOBILITY IN URBAN SPACE
Creators: name: KERAMAT JAHROMI, KARIM
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: Nowadays we witness a rapid increase of people mobility as the world population has become more interconnected and is relying on faster transportation methods, simplified connections and shorter commuting times. Unveiling and understanding human mobility patterns have become a crucial issue to support decisions and prediction activities when managing the complexity of the today's social organization. The strict connections between human mobility patterns, the planning, deployment and management of a variety of public and commercial services have fueled the rise of a vast research activity. Throughout this work, we are more interested and mainly focusing on urban mobility because here most of the human interactions take place and mobility has the greatest impact on management and optimization of public and commercial services. In this thesis, we provided a general framework for dealing with the modeling importance of locations from a per-user perspective and identified a few novel properties of human mobility. Also through characterizing the transition patterns driving user movement among visited places, we pave the way to propose a new mobility model in urban spaces. Meanwhile relying on the relevance of visited places, we propose a new algorithm for detecting and distinguishing Home and Workplaces. And finally, we suggest a framework for predicting the different aspects of Encounter/Colocation events. By exploiting the weighted Bayesian predictor we could enhance the accuracy of prediction w.r.t. the standard naive Bayesian and also to some other state-of-the-art predictors.
Evidence of research mastery: How applicants argue the feasibility of their research projects
Creators: name: Barlösius, Eva
name: Blem, Kristina
Publisher: name: Oxford : Oxford Univ. Press
Year: 2021
Subjects: subject: conservatism
subject: feasibility
subject: peer review
subject: projects
subject: proposals
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::050 | Zeitschriften, fortlaufende Sammelwerke

description: Although many studies have shown that reviewers particularly value the feasibility of a proposed project, very little attention has gone to how applicants try to establish the plausibility of their proposal’s realization. With a sample of 335 proposals, we examined the ways applicants reason the feasibility of their projects and the kinds of evidence they provide to support those assertions. We identified three kinds of evidence for mastering research: the scope of scientific skills, the presence of different assets, and the use of stylistic techniques. Applicants draw on them to align the project with scientific standards, embed it in the current state of research, and meet the scientific field’s expectations of how scientists should conduct a project. These kinds of evidence help substantiate a project’s feasibility and to distinguish the project from other proposals. Such evidence seems to correspond with a project’s positive review and approval (grant success). Evidence of research mastery was cited more often by the authors of the successful (approved) proposals than by the authors of the unsuccessful ones. The applicants of the successful proposals gave details of their planned experiments, emphasized their broad methodological and technical competence, and referred to their own preliminary scientific work.
Sound discrimination and explicit mapping of sounds to meanings in preschoolers with and without developmental language disorder
Creators: name: Quam, Carolyn
name: Cardinal, Holly
name: Gallegos, Celeste
name: Bodner, Todd
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: To investigate links between sound discrimination and explicit sound-meaning mapping by preschoolers with and without developmental language disorder (DLD). We tested 26 children with DLD and 26 age- and gender-matched peers with typical language development (TLD). Inclusion was determined via results of standardised assessments of language and cognitive skills and a hearing screening. Children completed two computerised tasks designed to assess pitch and duration discrimination and explicit mapping of pitch- and duration-contrasting sounds to objects. Children with TLD more successfully mapped pitch categories to meanings than children with DLD. Children with TLD also showed significantly better overall sound discrimination than children with DLD. Sound-discrimination scores were marginally associated with overall sound-meaning mapping in multivariate analyses of covariance (MANCOVAs). Correlation tests indicated significant associations between discrimination and mapping, with moderate to large effect sizes. Thus, significant sound-discrimination differences between the groups may contribute to differences in sound-meaning-mapping accuracy. Children with DLD had more difficulty mapping sound categories to meanings than TLD peers. We discuss possible explanations for this finding and implications for theoretical accounts of the aetiology of DLD.
ANALYSIS OF THE FREQUENCIES OF CD235A+CD71+ PRE-ERYTHROID CELLS IN PERIPHERAL BLOOD AND THEIR FUNCTION IN HIV INFECTED PEOPLE
Creators: name: TARKOWSKI, MACIEJ STANISLAW
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: Le cellule pre-eritroidi, caratterizzate dall?espressione di glicoforina A (CD235a) e recettore della transferrina (CD71) sono state precedentemente indicate in grado di modulare la risposta immunitaria e inibire la reazione infiammatoria. Poich� il processo dell?eritropoiesi � spesso alterato nel corso dell?infezione da HIV, � stato ipotizzato che le cellule pre-eitroidi, assenti in condizioni normali nel circolo periferico di adulti sani, possano essere riscontrate in soggetti con infezione da HIV ed esercitare un?attivit� immunomodulatoria. Lo scopo di questo studio � stato di investigare la presenza e la funzione di cellule pre-eritroidi riscontrata nel sangue periferico di soggetti adulti HIV positivi e HIV/HCV coinfetti, E? stato riportato che le cellule pre-eritroidi sono presenti nel sangue periferico di soggetti adulti HIV positivi e HIV/HCV coinfetti, e in particolare in soggetti che sviluppano anemia. Le cellule pre-eritroidi di questi individui hanno mostrato essere una fonte significativa di espressione di Arg 1, e l?attivit� plasmatica di questo enzima � stata trovata significativamente pi� elevata in entrambi i gruppi di pazienti con infezione da HIV in confronto con il gruppo di soggetti non infetti. Analisi in vitro dell?attivit� di cellule pre-eritroidi derivate da sangue di cordone ombelicale hanno confermato quanto precedentemente riportato e hanno mostrato che tali cellule sono in grado di diminuire i processi dell?attivazione immunitaria. Sebbene queste osservazioni possano essere confermate in alcuni casi di pazienti con infezione da HIV, l?effetto immunosoppressivo esercitato dalle loro cellule pre-eritroidi � meno marcato. Nonostante l?evidenza di un aumentato numero di cellule pre-eritroidi con potenziale attivit� immunosoppressiva, i pazienti anemici con infezione da HIV e coinfezione HIV/HCV, hanno mostrato valori di attivazione immunitaria o infiammatoria simili o addirittura pi� elevati rispetto ai pazienti infetti non anemici. La discrepanza di queste osservazioni pu� indicare che nonostante il potenziale carattere immunosoppressivo delle cellule pre-eritroidi la loro limitata permanenza nel distretto sanguigno periferico pu� non essere sufficientemente significativa nei confronti di reazioni pro-infiammatorie maggiormente sostenute. E? inoltre necessario considerare che in questo studio sono stati esplorati un numero limitato di marcatori di attivazione immunitarie e infiammatoria. La spiegazione di un potenziale effetto delle cellule pre-eritroidi durante il processo di anemizzazione in soggetti con infezione da HIV e HIV/HCV coinfetti richiede ulteriori studi e potrebbe essere di aiuto nella comprensione l?associazione tra anemia e aumento della mortalit�, aumento della progressione di malattia e ridotta qualit� della vita in questi gruppi di pazienti.
SXP 5.05 = IGR J00569-7226 : using X-rays to explore the structure of a Be stars circumstellar disk
Creators: name: Coe, M. J.
name: Bartlett, E. S.
name: Bird, A. J.
name: Haberl, F.
name: Kennea, J. A.
name: McBride, V. A.
name: Townsend, L. J.
name: Udalski, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: On MJD 56590-1 (2013 Oct 25-26) observations of the Magellanic Clouds by the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) observatory discovered a previously-unreported bright, flaring X-ray source. This source was initially given the identification IGR J00569-7226. Subsequent multi-wavelength observations identified the system as new Be/X-ray binary system in the Small Magellanic Cloud. Follow-up X-ray observations by Swift and XMM-Newton revealed an X-ray pulse period of 5.05s and that the system underwent regular occulation/eclipse behaviour every 17d. This is the first reported eclipsing Be/X-ray binary system in the SMC, and only the second such system known to date. Furthermore, the nature of the occultation makes it possible to use the neutron star to X-ray the circumstellar disk, thereby, for the first time, revealing direct observational evidence for its size and clumpy structure. Swift timing measurements allowed for the binary solution to be calculated from the Doppler shifted X-ray pulsations. This solution suggests this is a low eccentricity binary relative to others measured in the SMC. Finally it is interesting to note that the mass determined from this dynamical method for the Be star (approx 13 solar masses) is significantly different from that inferred from the spectroscopic classification of B0.2Ve (approx 16 solar masses) - an effect that has been noted for some other high mass X-ray binary (HMXB) systems.
description: 19 pages, accepted by MNRAS
A low-energy limit of Yang-Mills theory on de Sitter space
Creators: name: Cork, Josh
name: Kutluk, Emine Şeyma
name: Lechtenfeld, Olaf
name: Popov, Alexander D.
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2021
Subjects: subject: Effective Field Theories
subject: Gauge Symmetry
subject: Sigma Models
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: We consider Yang-Mills theory with a compact structure group G on four-dimensional de Sitter space dS4. Using conformal invariance, we transform the theory from dS4 to the finite cylinder I × S3, where I = (−π/2, π/2) and S3 is the round three-sphere. By considering only bundles P → I × S3 which are framed over the temporal boundary ∂I × S3, we introduce additional degrees of freedom which restrict gauge transformations to be identity on ∂I × S3. We study the consequences of the framing on the variation of the action, and on the Yang-Mills equations. This allows for an infinite-dimensional moduli space of Yang-Mills vacua on dS4. We show that, in the low-energy limit, when momentum along I is much smaller than along S3, the Yang-Mills dynamics in dS4 is approximated by geodesic motion in the infinite-dimensional space Mvac of gauge-inequivalent Yang-Mills vacua on S3. Since Mvac ≅ C∞(S3, G)/G is a group manifold, the dynamics is expected to be integrable.
Optimization of Steel Production Scheduling with Complex TimeSensitive Electricity Cost
Creators: name: Hadera, Hubert
name: Harjunkoski, Iiro
name: Sand, Guido
name: Grossmann, Ignacio E.
name: Engell, Sebastian
Publisher: name: Figshare
Year: 2018
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: Energy-intensive industries can take advantage of process flexibility to reduce operating costs by optimal scheduling of production tasks. In this study we develop a MILP formulation to extend a continuous-time model with energy-awareness to optimize the daily production schedules and the electricity purchase including the load commitment problem. The sources of electricity that are considered are purchase on volatile day-ahead markets, time-of-use (TOU) contracts and base load contracts, as well as onsite generation. The possibility to sell electricity back to the grid is also included. The model is applied to the melt shop section of a stainless steel plant. Due to the large-scale nature of the combinatorial problem which prevents the solution of a monolithic model to nearoptimality, we propose a bi-level heuristic algorithm to tackle instances of industrial size. Case study scenarios show that the potential impact of high prices in the day-ahead markets of electricity can be mitigated by jointly optimizing the production schedule and the associated net electricity consumption cost.
FORMAZIONE DELLA FAMIGLIA, FECONDITA' E STRATIFICAZIONE SOCIALE NELL'ITALIA DAL DOPOGUERRA A OGGI
Creators: name: CANTALINI, STEFANO
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: This work focuses on three issues: a) the impact of social position on family formation and fertility; b) the effect of marriage and parenthood on occupational career; c) the differences by social position in the impact of family behaviors on occupational career. By adopting a life-course perspective and studying individuals and couples, it combines two topics kept separated by previous research, connecting them with the traditional approaches of social stratification. The main aim is to study if and how family formation and fertility can explain social inequalities over the life course in Italy after the Second World War. After a historical reconstruction of demographic events in Italy and their connections with socio-economic characteristics, the main results from the first part show that high-educated people postpone family formation and only men are able to catch up with low educated in the long run, while high-educated women maintain lower probabilities of creating a family because of the persistence of opportunity costs all over the life course. Gender differences appear in the association between social position and higher order births too: having a tertiary degree decreases transition to third birth only among women. Moreover, by studying the couple it has been shown that while in the transition to the first child it is primarily the mother?s socio-economic characteristics that matter, the transitions to higher-order births are largely driven by men?s education. The second part of the work has confirmed that family formation is a crucial event to explain gender differences in labour supply, since it implies an immediate and temporary increase in the probability of being employed for men, whereas it strongly decreases employment opportunities for women, that remain permanently lower over the life course. Small effects of family behaviors have been found concerning what career opportunities, because of a low degree of intragenerational mobility and a high selection of women into employment. However, it has been shown that some disadvantages for mothers in occupational prestige appear around ten years after the birth of the first child, as a result of a block in their career. The last part of the research has shown that employment trajectories after motherhood are significantly different according to social position and the penalization over the life-course applies only to low-educated women. In a context of low career mobility and high selection of women into employment, finally, family formation slightly reduces social inequalities in occupational careers over the life course for women and slightly increase them for men. The work concludes with some policy suggestions to reduce gender and social inequalities in Italy.
Local quantum ergodic conjecture
Creators: name: Zambrano, E.
name: Zapfe, W. P. Karel
name: de Almeida, Alfredo M. Ozorio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Quantum Ergodic Conjecture equates the Wigner function for a typical eigenstate of a classically chaotic Hamiltonian with a delta-function on the energy shell. This ensures the evaluation of classical ergodic expectations of simple observables, in agreement with Shnirelman's theorem, but this putative Wigner function violates several important requirements. Consequently, we transfer the conjecture to the Fourier transform of the Wigner function, that is, the chord function. We show that all the relevant consequences of the usual conjecture require only information contained within a small (Planck) volume around the origin of the phase space of chords: translations in ordinary phase space. Loci of complete orthogonality between a given eigenstate and its nearby translation are quite elusive for the Wigner function, but our local conjecture stipulates that their pattern should be universal for ergodic eigenstates of the same Hamiltonian lying within a classically narrow energy range. Our findings are supported by numerical evidence in a Hamiltonian exhibiting soft chaos. Heavily scarred eigenstates are remarkable counter-examples of the ergodic universal pattern.
description: 4 figures
Data for journal article Insights into the petrogenetic history of the Northwest Africa 7635 augite-rich shergottite
Creators: Herd, Christopher D.K.
Publisher: name: University of Alberta Library
Year: 2020

Raw data in Excel format from the Electron Microprobe Lab at the University of Alberta used in Herd (2022) Insights into the petrogenetic history of the Northwest Africa 7635 augite-rich shergottite, Meteoritics and Planetary Science.
Stranger, Lover, Friend? : The Pain of Rejection Does Not Depend
Creators: name: Böckler, Anne
name: Rennert, Annika
name: Raettig, Tim
Publisher: name: Bern ; Göttingen [u.a.] : Hogrefe & Huber
Year: 2021
Subjects: subject: interpersonal relationships
subject: ostracism
subject: rejection
subject: social exclusion
subject: social interaction
subject: Dewey Decimal Classification::100 | Philosophie::150 | Psychologie
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie

description: Social exclusion, even from minimal game-based interactions, induces negative consequences. We investigated whether the nature of the relationship with the excluder modulates the effects of ostracism. Participants played a virtual ball-tossing game with a stranger and a friend (friend condition) or a stranger and their romantic partner (partner condition) while being fully included, fully excluded, excluded only by the stranger, or excluded only by their close other. Replicating previous findings, full exclusion impaired participants' basic-need satisfaction and relationship evaluation most severely. While the degree of exclusion mattered, the relationship to the excluder did not: Classic null hypothesis testing and Bayesian statistics showed no modulation of ostracism effects depending on whether participants were excluded by a stranger, a friend, or their partner.
Process control strategies for constrained nonlinear systems
Creators: name: Wei-Chong  Li
name: Biegler, Lorenz T.
name: Carnegie Mellon University.Engineering Design Research Center.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: Abstract: "Control and state variable constraints are often overlooked in the development of control laws. Although recent developments with DMC and QDMC have addressed this problem for linear systems, incorporation of state and control variable constraints for nonlinear control problems has seen relatively little development. In this paper, a nonlinear control strategy based on operator theory is extended to deal with control and state variable constraints. Here we show that Newton-type control algorithms can easily be generalized using an on-line optimization approach. In particular, a special form of a successive quadratic programming (SQP) strategy is used to handle control and state variable contraints.Moreover, the constrained approach can be shown to fit into the IMC structure proposed by Economou and Morari. Using the small gain theory of Zames, we show that constraints on state and control variables can replace the design of a nonlinear filter for noninvertible processes and thereby lead to stable controllers. The advantage to this approach, however, is that constraints are relatively straightforward to apply since the limits of their response are known in advance.After presenting a detailed description of the method, a number of scenarios are considered for the control of nonlinear reactor models. These models cannot in general be controlled using linear control strategies. With the nonlinear constrained approach, on the other hand, regulation and control can be done in a straightforward manner, and emphasis to more important parts of the system can be given with appropriate placement of constraints."
title: Клинический случай чистой дисгенезии гонад – синдрома Свайера
title: Clinical Case of Pure Gonadal Dysgenesis – Swyer Syndrome
Creators: name: Верховых, Елена Викторовна
name: Гирш, Яна Владимировна
name: Калинченко, Наталья Юрьевна
Publisher: name: Издательский центр СурГУ
Year: 2022

description: Цель – представить клинический случай чистой дисгенезии гонад у пациентки. Материалы
и методы. Представлен клинический случай синдрома Свайера у девушки 16 лет, проанализированы анамнестические и клинические данные, результаты лабораторных и инструментальных обследований, постоперационные
результаты и эффект заместительной гормональной терапии. Результаты. В процессе обследования подростка
с женским фенотипом, высокорослостью и первичной аменореей выявлено повышение гонадотропинов и гипоплазия матки. При цитогенетическом исследовании установлен кариотип 46, ХУ. Проведено лапароскопическое удаление двусторонних гонадобластом с последующим подбором заместительной гормональной терапии.
description: The study aims to present a clinical case of pure gonadal dysgenesis in a female patient. Materials
and methods. A clinical case of Swyer syndrome in a 16-year-old girl is presented. The anamnestic and clinical
data, the results of laboratory and instrumental examinations, postoperative results and the effect of hormone
replacement therapy were analyzed. Results. During the examination of a teenager with a female phenotype, tall
stature and primary amenorrhea, an increase in gonadotropins and uterine hypoplasia were recorded. Cytogenetic
examination revealed a 46,XY karyotype. Laparoscopic removal of bilateral gonadoblastoma was performed,
followed by the selection of hormone replacement therapy.
Microscale tipstreaming in a microfluidic flow focusing device
Creators: name: Anna, Shelley
name: Mayer, Hans C
Publisher: name: Figshare
Year: 2018
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: A microfluidic flow-focusing device is used to explore the use of surfactant-mediated tipstreaming to synthesize micrometer-scale and smaller droplets. By controlling the surfactant bulk concentration of a soluble nonionic surfactant in the neighborhood of the critical micelle concentration, along with the capillary number and the ratio of the internal and external flow rates, we observe several distinct modes of droplet breakup. For the most part, droplet breakup in microfluidic devices results in highly monodisperse droplets in the range of tens of micrometers in size. However, we observe a new mode of breakup called “thread formation” that resembles tipstreaming and yields tiny droplets in the range of a few micrometers in size or smaller. In this work, we characterize the growth of the thread and its maximum length as a function of flow variables and surfactant content, and we also characterize the period of droplet breakup as a function of these variables. Our results suggest possible methods for controlling the process. Using a simple flow visualization experiment as the basis, we report on preliminary efforts to model the thread formation process.
LA COMPLESSIT� DEL PAESAGGIO DELLE CINQUE TERRE: SEGNI MATERIALI, SIGNIFICATI CULTURALI E INTERPRETAZIONI
Creators: name: GILARDI, THOMAS
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Il presente lavoro studia il paesaggio delle Cinqueterre con un approccio umanistico nel tentativo di comprendere quali esperienze collaborano a modificarne la percezione. Per questo scopo � stata realizzata una ricerca bibliografica relativa alle diverse interpretazioni del paesaggio e si sono messe in evidenza le criticit� relative alle sue implicazioni con il concetto di identit�. Quindi � stata realizzata una ricerca sul campo che ha visto l'elaborazione di dati raccolti in circa 350 questionari. I risultati della ricerca sono stati principalmente due: uno relativo al peso delle esperienze paesaggistiche maturate nel corso della vita degli intervistati; l'altro relativo al peso delle esperienze paesaggistiche in corso.
Muonless Events in ICAL at INO
Creators: name: Ajmi, Ali
name: Sankar, S. Uma
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The primary physics signal events in the ICAL at INO are the $ν_μ$ charged current (CC) interactions with a well defined muon track. Apart from these events, ICAL can also detect other types of neutrino interactions, i.e. the electron neutrino charged current interactions and the neutral current events. It is possible to have a dataset containing mostly $ν_e$CC events, by imposing appropriate selection cuts on the events. The $ν_μ$ CC and the neutral current events form the background to these events. This study uses the Monte Carlo generated neutrino events, to design the necessary selection cuts to obtain a $ν_e$ CC rich dataset. An optimized set of constraints are developed which balance the need for improving the purity of the sample and having a large enough event sample. Depending on the constraints used, one can obtain a neutrino data sample, with the purity of $ν_e$ events varying between 55% to 70%.
description: 21 pages, 6 figures
title: Relational Turning Point Events in der Beziehungsentwicklung von Lehramtsstudierenden im Teampraktikum
Creators: name: Hagenauer, Gerda
name: de Zordo, Lea
name: Waber, Jennifer
Publisher: name: Waxmann
Year: 2021

description: Eine wesentliche Gelingensbedingung von Teampraktika stellt die Qualität der Beziehung zwischen den Lehramtsstudierenden dar, die sich auf der professionellen Ebene („Arbeitsbeziehung“) sowie auch auf der interpersonalen Dimension („Nähe“) beschreiben lässt. Bisher ist wenig über die Entwicklung dieser Beziehungen bekannt. Daher setzt sich die vorliegende Studie das Ziel, auf Basis sogenannter Relational Turning Point Events jene Bedingungen zu identifizieren, die zu einer positiven oder negativen Beziehungsentwicklung beitragen. Auf Basis eines qualitativen Designs wurden 27 Schweizer Lehramtsstudierende zu den erlebten Relational Turning Point Events im Teampraktikum mittels Leitfadeninterviews befragt. Die Ergebnisse zeigen, dass sich im Zuge des Praktikums unterschiedliche Beziehungsqualitäten entwickelten, die als freundschaftlich, sachlich oder distanziert charakterisiert werden konnten. Zahlreiche annähernde und distanzierende Relational Turning Point Events beeinflussten die Beziehungsentwicklung. Für die Entwicklung der professionellen Beziehung war insbesondere die Qualität der Zusammenarbeit von Bedeutung, während für den Aufbau der interpersonalen Beziehung vor allem die Selbstoffenbarung eine Rolle spielte. Professionelle Distanzierung wurde erlebt, wenn die Zusammenarbeit nicht klappte; zur interpersonalen Distanzierung führten insbesondere Schwierigkeiten in der interpersonalen Kommunikation. Die Ergebnisse werden im Hinblick auf die Ausgestaltung der schulpraktischen Studien diskutiert.
Plate-height model of ion mobility-mass spectrometry: Part 2—Peak-to-peak resolution and peak capacity
Creators: name: Grabarics, Márkó
name: Lettow, Maike
name: Kirk, Ansgar T.
name: Helden, Gert
name: Causon, Tim J.
name: Pagel, Kevin
Publisher: name: Weinheim : Wiley-VCH
Year: 2021
Subjects: subject: drift tube
subject: ion mobility spectrometry
subject: peak capacity
subject: peak resolution
subject: traveling wave
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie
subject: Dewey Decimal Classification::600 | Technik::660 | Technische Chemie

description: In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. On the basis of these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Furthermore, we present exact resolution equations for drift tube ion mobility spectrometry based on first principles. Upon implementing simple modifications, these exact formulae could be readily extended to traveling wave ion mobility separations and to cases when ion mobility spectrometry is coupled to mass spectrometry. The second part focuses on peak capacity. The well-known assumptions of constant plate number and constant peak width form the basis of existing approximate solutions. To overcome their limitations, an exact peak capacity equation is derived for drift tube ion mobility spectrometry. This exact solution is rooted in a suitable physical model of peak broadening, accounting for the finite injection pulse and subsequent diffusional spreading. By borrowing concepts from the theoretical toolbox of chromatography, we believe that the present study will help in integrating ion mobility spectrometry into the unified language of separation science.
Surface modification of decellularized bovine carotid arteries with human vascular cells significantly reduces their thrombogenicity
Creators: name: Keshi, Eriselda
name: Tang, Peter
name: Weinhart, Marie
name: Everwien, Hannah
name: Moosburner, Simon
name: Seiffert, Nicolai
name: Lommel, Michael
name: Kertzscher, Ulrich
name: Globke, Brigitta
name: Reutzel-Selke, Anja
name: Strücker, Benjamin
name: Pratschke, Johann
name: Sauer, Igor Maximillian
name: Haep, Nils
name: Hillebrandt, Karl Herbert
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2021
Subjects: subject: Bypass
subject: Decellularization
subject: Recellularization
subject: Vascular graft
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Background: Since autologous veins are unavailable when needed in more than 20% of cases in vascular surgery, the production of personalized biological vascular grafts for implantation has become crucial. Surface modification of decellularized xenogeneic grafts with vascular cells to achieve physiological luminal coverage and eventually thromboresistance is an important prerequisite for implantation. However, ex vivo thrombogenicity testing remains a neglected area in the field of tissue engineering of vascular grafts due to a multifold of reasons. Methods: After seeding decellularized bovine carotid arteries with human endothelial progenitor cells and umbilical cord-derived mesenchymal stem cells, luminal endothelial cell coverage (LECC) was correlated with glucose and lactate levels on the cell supernatant. Then a closed loop whole blood perfusion system was designed. Recellularized grafts with a LECC > 50% and decellularized vascular grafts were perfused with human whole blood for 2 h. Hemolysis and complete blood count evaluation was performed on an hourly basis, followed by histological and immunohistochemical analysis. Results: While whole blood perfusion of decellularized grafts significantly reduced platelet counts, platelet depletion from blood resulting from binding to re-endothelialized grafts was insignificant (p = 0.7284). Moreover, macroscopic evaluation revealed thrombus formation only in the lumen of unseeded grafts and histological characterization revealed lack of CD41 positive platelets in recellularized grafts, thus confirming their thromboresistance. Conclusion: In the present study we were able to demonstrate the effect of surface modification of vascular grafts in their thromboresistance in an ex vivo whole blood perfusion system. To our knowledge, this is the first study to expose engineered vascular grafts to human whole blood, recirculating at high flow rates, immediately after seeding.
Multivariate $α$-molecules
Creators: name: Flinth, Axel
name: Schäfer, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 41A30, 41A63, 42C40

description: The suboptimal performance of wavelets with regard to the approximation of multivariate data gave rise to new representation systems, specifically designed for data with anisotropic features. Some prominent examples of these are given by ridgelets, curvelets, and shearlets, to name a few. The great variety of such so-called directional systems motivated the search for a common framework, which unites many under one roof and enables a simultaneous analysis, for example with respect to approximation properties. Building on the concept of parabolic molecules, the recently introduced framework of $α$-molecules does in fact include the previous mentioned systems. Until now however it is confined to the bivariate setting, whereas nowadays one often deals with higher dimensional data. This motivates the extension of this unifying theory to dimensions larger than 2, put forward in this work. In particular, we generalize the central result that the cross-Gramian of any two systems of $α$-molecules will to some extent be localized. As an exemplary application, we investigate the sparse approximation of video signals, which are instances of 3D data. The multivariate theory allows us to derive almost optimal approximation rates for a large class of representation systems.
Medicare Expenditures and Healthcare Utilization in a Multi-ethnic Community-based Population with Dementia from Incidence to Death
Creators: Ornstein, Katherine A.
Zhu, Carolyn W.
Bollens-Lund, Evan
Aldridge, Melissa D.
Andrews, Howard F.
Schupf, Nicole
Stern, Yaakov
Publisher: name: Columbia University
Year: 2018
Subjects: Dementia
Medicare
Medical care, Cost of
Ethnic groups--Medical care

description: Introduction: While individuals live with dementia for many years, utilization and expenditures from disease onset through the end-of-life period have not been examined in ethnically diverse samples. Methods: We used a multiethnic, population-based, prospective study of cognitive aging (Washington Heights-Inwood Columbia Aging Project) linked to Medicare claims to examine total Medicare expenditures and health care utilization among individuals with clinically diagnosed incident dementia from disease onset to death. Results: High-intensity treatment (hospitalizations, life-sustaining procedures) was common and mean Medicare expenditures per year after diagnosis was $69,000. Non-Hispanic blacks exhibited higher spending relative to Hispanics and non-Hispanic whites 1 year after diagnosis. Non-Hispanic blacks had higher total (mean=$205,000) Medicare expenditures from diagnosis to death compared with non-Hispanic whites (mean=$118,000). Hispanics’ total expenditures and utilization after diagnosis was similar to non-Hispanic whites despite living longer with dementia. Discussion: Health care spending for patients with dementia after diagnosis through the end-of-life is high and varies by ethnicity.
Well-posedness of a diffuse-interface model for two-phase incompressible flows with thermo-induced Marangoni effect
Creators: name: Wu, Hao
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35A01, 35A02, 35K20, 35Q35

description: We investigate a non-isothermal diffuse-interface model that describes the dynamics of two-phase incompressible flows with thermo-induced Marangoni effect. The governing PDE system consists of the Navier--Stokes equations coupled with convective phase-field and energy transport equations, in which the surface tension, fluid viscosity and thermal diffusivity are temperature dependent functions. First, we establish the existence and uniqueness of local strong solutions when the spatial dimension is two and three. Then in the two dimensional case, assuming that the $L^\infty$-norm of the initial temperature is suitably bounded with respect to the coefficients of the system, we prove the existence of global weak solutions as well as the existence and uniqueness of global strong solutions.
description: accepted by Euro. J. Appl. Math. in June 2016
When Experiments Need Models
Creators: name: Khosrowi, Donal
Publisher: name: Thousand Oaks, Calif. [u.a.] : Sage
Year: 2021
Subjects: subject: evidence-based policy
subject: experiment-target inference
subject: experiments
subject: external validity
subject: extrapolation
subject: models
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie

description: This paper argues that an important type of experiment-target inference, extrapolating causal effects, requires models to be successful. Focusing on extrapolation in Evidence-Based Policy, it is argued that extrapolation should be understood not as an inference from an experiment to a target directly, but as a hybrid inference that involves experiments and models. A general framework, METI, is proposed to capture this role of models, and several benefits are outlined: (1) METI highlights epistemically significant interactions between experiments and models, (2) reconciles some differences among existing accounts of experiment-target relationships, and (3) facilitates critical appraisal of inferential practices from experiments.
THE RIGHT TO HAVE A SAY: A THEORY OF JUSTICE FOR DISAGREEMENTS
Creators: name: FUMAGALLI, CORRADO
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: The central claim of this work is straightforward: if one endorses a nonexclusionary standpoint, then one ought also to avoid excluding people from disagreements. This is valid even if these people hold particularly deplorable worldviews. In political theory, this is not the generally held view. Political liberalism has endorsed the exclusion of unreasonable people. More or less explicitly, modus vivendi theory also limits access to the relevant constituency for those people who do not share the higher good of peace, or who are unable to meet other requirements. In this work, I aim to demonstrate that exclusion is bad. Therefore, the point of this project is to begin with the debate on pluralism and disagreement in order to affirm a novel normative standpoint ? a non-exclusionary political theory. This theory defends a general right to have a say. To do so, I divide the argument into three parts. First, I define the non-exclusionary desideratum. I also pay attention to conceptual difficulties in existing responses to pluralism in political theory. Then, to answer the need to construct a normative standpoint that people with different worldviews can affirm, I develop a perspectivist political theory. In the second part of this work, I recognize two orders of normativity, and I idealize an ideal position of disagreement ? the many-to-one relationship. At the heart of this normative proposal, there is a general standpoint of justice (the right to have a say), and a conception of legitimacy for societies where all members have a right to have a say. For me, a decision is legitimate when all members can recognize their individual subject-object relations in the outcome. Finally, in the third part of the dissertation, I consider the pluralistic society ? an ideal society where all members have a right to have a say.
Stimulated Raman Scattering and Nonlinear Focusing of High-Power Laser Beams Propagating in Water
Creators: name: Hafizi, B.
name: Palastro, J. P.
name: Penano, J. R.
name: Gordon, D. F.
name: Jones, T. G.
name: Helle, M. H.
name: Kaganovich, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The physical processes associated with propagation of a high-power (power > critical power for self-focusing) laser beam in water include nonlinear focusing, stimulated Raman scattering (SRS), optical breakdown and plasma formation. The interplay between nonlinear focusing and SRS is analyzed for cases where a significant portion of the pump power is channeled into the Stokes wave. Propagation simulations and an analytical model demonstrate that the Stokes wave can re-focus the pump wave after the power in the latter falls below the critical power. It is shown that this novel focusing mechanism is distinct from cross-phase focusing. While discussed here in the context of propagation in water, the gain-focusing phenomenon is general to any medium supporting nonlinear focusing and stimulated forward Raman scattering.
MOLECULAR ASPECTS OF ALZHEIMER'S DISEASE PATHOGENESIS: FROM LOCAL SPINE TRAFFICKING TO LONG DISTANCE SPINE TO NUCLEUS SIGNALLING.'TOWARDS NEW THERAPEUTICS INTERVENTION'
Creators: name: MUSARDO, STEFANO
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: The molecular pathogenesis of Alzheimer?s disease (AD) is still controversial, although genetic and cell biology findings indicate accumulation of A?, especially in soluble oligomeric conformation, as the driving force of synaptic dysfunction with concomitant activation of complex cascade of molecular events leading to dementia. In the last few years, several studies aimed at understanding how A? accumulation and assembly compromise synaptic structure and function of excitatory synapses. In this study, we evaluated how A? can affect the local and the long-distance trafficking, since the alteration of these mechanisms could represent a key determinant for synaptic dysfunction. We focused the attention on ADAM10, which activity prevents A? production. Notably the regulation of ADAM10 synaptic localization is neuronal activity-dependent, in particular LTP decrease, while LTD foster ADAM10 surface expression. Here we found that A?42 (500nM, 30 min) exposure results in an increase of ADAM10 synaptic availability. In particular, A?42 treatment leads to a decrease in the association between ADAM10 and AP2 complex, suggesting that the augment in ADAM10 synaptic localization is due to a decrease of the endocytosis. Interestingly, this mechanism is completely lost in the context of AD, suggesting that the increase in ADAM10 endocytosis, and thus the reduction of its activity towards APP, could be a synaptic mechanism of AD pathogenesis. In light of this consideration, we developed CPPs able to interfere with ADAM10 clathrin-mediated endocytosis and to restore the unbalance between exo- and endocytosis. This tool can be considered a potential disease-modifying strategy capable of modifying the progression of the disease and rescuing the pathological phenotype. Afterwards we describe a novel synapse-to-nucleus signaling pathway, involving the RNF10 protein, that specifically links activation of synaptic GluN2A-containing NMDARs to nuclear gene expression. In physiological conditions, RNF10 dissociates from the NMDAR complex in an activity-dependent manner and we provide compelling evidence for importin-dependent long-distance transport from synapto-dendritic compartments to the nucleus. These findings suggest that synaptonuclear trafficking of RNF10 is involved in the control of gene expression, which is necessary for synaptic plasticity in hippocampal neurons. Here we demonstrated that A? can affect RNF10 long-distance trafficking. In particular, during acute exposure, A? induces RNF10 translocation while in a chronic AD pathological context we found a reduction of the translocation, suggesting that RNF10 could be involved in AD pathogenesis.
Local estimates for parabolic equations with nonlinear gradient terms
Creators: name: Leonori, Tommaso
name: Petitta, Francesco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35K60, 35D05, 35D10

description: In this paper we deal with local estimates for parabolic problems in $\mathbb{R}^N$ with absorbing first order terms, whose model is $\{ {l} u_t- Δu +u |\nabla u|^q = f(t,x) \quad &{in}\, (0,T) \times \mathbb{R}^N\,, \\[1.5 ex] u(0,x)= u_0 (x) &box{in}\, \mathbb{R}^N.$ where $T>0$, $N\geq 2$, $1
Do Academically Struggling Students Benefit From Continued Student Loan Access? Evidence From University and Beyond
Creators: name: Chu, Yu-Wei
name: Cuffe, Harold E
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: subject: 140299 Applied Economics not elsewhere classified
subject: FOS: Economics and business
subject: 140399 Econometrics not elsewhere classified

description: Abstract We estimate the effects of student loan access on educational attainment and labor market returns in New Zealand. We exploit the introduction of a national policy mandating a 50% pass rate for student loan renewals using a regression discontinuity design. Retaining loan access increases re-enrollment for students around the threshold, and a majority eventually graduate with a bachelor's degree within seven years. We find that retaining student loan access leads to large labor market returns for struggling students. The additional debt from further borrowing is both small relative to the earnings returns and declines quickly due to faster repayment.