cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis
Creators: name: Poon, Wynne Hsing
name: Ramanathan, Kollengode
name: Ling, Ryan Ruiyang
name: Yang, Isabelle Xiaorui
name: Tan, Chuen Seng
name: Schmidt, Matthieu
name: Shekar, Kiran
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary tables and figures.
Leo Wehrli 1870-1954
Creators: name: Wehrli, Leo
Publisher: name: ETH Zurich
Year: 1988
Subjects: Wehrli, Leo
GLASBILDER, DIAPOSITIVE (PHOTOGRAPHIE)
LATERN SLIDES ON GLASS (PHOTOGRAPHY)
info:eu-repo/classification/ddc/550
info:eu-repo/classification/ddc/910
Earth sciences
Geography & travel

description: Handschriften und Autographen der ETH-Bibliothek, 100
title: Πολυκριτήρια και στατιστική ανάλυση των μεγαλύτερων χρηματοπιστωτικών ιδρυμάτων του κόσμου
Creators: name: Μουριάδου Γεωργία
name: Μπαρόλα Σωτηρία
Publisher: name: Technical University of Crete
Year: 2005

description: Μη διαθέσιμο
Cadmium accumulation in rice: insight from window exposure tests
Creators: name: Song, Zhiyi
Publisher: name: No Publisher Supplied
Year: 2022

description: The consumption of rice grain with Cd contamination is the major Cd dietary exposure pathway which causes serious health problems. The Cd control techniques of rice plant aim to: 1) lower total Cd in soil environment, 2) lower bioavailability of Cd in soil environment to limit the transfer from environment to rice plant, and 3) modify Cd transfer process within rice plant to limit Cd transfer from other plant part to rice grain. In Cd control experiments, the efficacy of Cd reduction techniques varied when applied in different growth time of rice plant. With different physiological parameters and varied metabolism rate in each growth stage, rice plant might show different Cd uptake ability during growth. The key growth stage which shows the highest Cd uptake and/or the greatest accumulation in rice grain after maturity might be the most suitable time to apply Cd control techniques.In this dissertation, both non-labeled and stable-isotopically labeled Cd were applied in a newly designed hydroponic-soil combined culture cultivation experiment named “window exposure”. Window exposure experiments were performed by exposing rice plants to Cd at different stages of growth. The quantification of Cd mass distribution in exposure media and each plant part at different sampling times demonstrates not only Cd mass flows between exterior soil environment and rice plant, but Cd mass also flows between different plant parts during growth. The change of Cd mass accumulation in rice plant over time indicates continued mass exchange between plant and soil environment. Depending on metabolic rate and other physiological parameters, the translocation and redistribution of Cd in rice vary with growth stage. Four Cd mass flows models quantitatively Cd retention and translocation in each plant tissue following short-term Cd window exposure in seedling, tillering, flowering, and milking stages.Results from this work indicate that the Cd uptake ability of rice increases with the development of biomass. Flowering stage is the key growth stage which contributes to the highest Cd accumulation in rice, which results from both high Cd influx and low efflux during growth after window exposure. Although rice seedlings show low Cd influx and high Cd efflux from time of exposure to maturity, the dramatic reduction of physiological parameters in maturity indicates severe adverse impacts of Cd when rice plant is window-exposed to Cd in early growth stage. Cd exposure treatment during tillering stage results in higher Cd retention within the rice plant compared to the window exposure treatments at other growth times. This suggests a detoxification mechanism of Cd compartmentalization in leaves when exposed to Cd in early growth stages. These findings improve our understanding of how Cd transfer processes in rice vary in different growth stages, which would be used to guide future applications of Cd control techniques for remedy of contaminated rice paddy fields.
Technologies of the quotidian: British empire, race, and the biopolitics of security
Creators: name: Haziz-Ginsberg, A.
Publisher: name: No Publisher Supplied
Year: 2022

description: This dissertation considers how banal encounters with state security simultaneously produce the legitimacy of the state and the coherence of race in mainland Britain and Northern Ireland. Reading the colonial and metropolitan alongside one another, the dissertation follows two lines of inquiry. First, I consider how ordinary engagements with the state enabled by infrastructures of surveillance such as the emergency telephone are key sites where common sense logics of race and nation are forged. Second, I trace how the figure of the terrorist not only consolidates hegemonic understandings of security but is itself a malleable technology that enables the expansion and relegitimation of counterterrorism as a form of policing and as a site of governance. I utilize interdisciplinary methods—including archival research, participant observation, and discourse analysis—to engage contemporary political questions through jointly historical and theoretical frameworks. Throughout the dissertation, I describe how state power in myriad forms is legitimized through techniques often understood to be benevolent. Beginning in chapter one with the development of 999, the first emergency telephone service, I consider how this becomes a site where quotidian understandings of emergency are produced and normative paradigms of security are simultaneously cohered. This earlier technology, I argue, provides both the material and affective ground for more expansive forms of citizen-surveillance and state security, such as counterterrorist reporting initiatives deployed both in colonial and metropolitan contexts. In chapter two, I examine the deployment of emergency calling towards colonial ends in Northern Ireland via the Confidential Telephone. Chapter three examines the figure of the Irish terrorist via a settler colonial lens and parses the transit between this figure and the paradigmatic discourses and figurations of terrorism and counterterror that shape the contemporary. The last chapter examines the discourses around far right violence in the contemporary UK, tracking the reconfigurations of counterterrorism in relation to the figure of the far right terrorist. I argue that the expansion of targets has allowed counterterrorism to be reorganized as a more efficacious state practice. Throughout, I focus on the relationship between seemingly banal practices which have often escaped critical scrutiny, and more exceptional forms of emergency such as counterterrorism, a highly visible security project which is more widely understood to be racializing in its effects. Mapping histories that have previously not been read together, I argue that it is in the most banal encounters with the state that security is legitimized and the common sense logics of the nation and race are forged.
title: Reading across the manuscripts: the process of cartularisation at Arbroath Abbey
Creators: name: Stevenson, Hilary
Publisher: name: University of Glasgow
Year: 2023

description: This thesis examines how ‘cartularisation’ was practiced at the Tironensian abbey of Arbroath over three centuries from c.1250–c.1560. While previous studies have generally focused on single cartularies, this study looks at it from an institutional perspective, by examining the corpus of cartularies surviving from the medieval abbey, focusing on those that related to the community rather than an individual abbot or commendator. In particular, the thesis examines cartularisation in light of the recent work of Joanna Tucker, whose study of two Scottish cartularies (each drawn from a separate institution) demonstrated that it was a community activity in its own right, rather than just the means by which manuscripts were created. This thesis builds upon her findings to better understand how successive generations of scribes engaged with the wider corpus of manuscripts than just the one to which they were contributing. To do so, it is first necessary to fully examine each of the four cartularies chosen for this study and an in-depth analysis of each one can be found in Chapters 1 to 4. Using Tucker’s newly established methodology for examining multi-scribe cartularies, the evolution of each cartulary is examined to provide a comprehensive understanding of how the character of each one was shaped by the choices made by contributing scribes. Once the nature of each individual cartulary has been uncovered, the evidence these analyses provide is brought together to demonstrate how scribes worked over the longer period. Chapter 5 charts the timeline of document copying at Arbroath and compares the various ‘campaigns’ involved in creating each cartulary. Chapter 6 shows that where repeated texts occur (either within a single volume or across the corpus) they were the rarely the result of scribal error, but that scribes had a working knowledge of what had previously been copied. The evidence for scribes as readers of all the abbey’s manuscripts is extended in Chapter 7, which examines the cross-references found within all of the extant cartularies of Arbroath that indicate the cartularies were seen as a corpus in their own right, and not just a substitute for the abbey’s archive. Through these different analyses it becomes possible to see copying as more than just a method to create single manuscript volumes but as an intergenerational communal activity. Scribes are shown to be deeply aware of what had been copied by their predecessors, a knowledge which influenced their own choices. As time progresses, however, it is also possible to see scribes copying documents that relate to contemporary concerns and interests. By reading across the manuscripts and tracking the patterns of copying over three centuries it becomes possible to see cartularisation at Arbroath not as a series of single projects to create individual bound volumes, but as an ongoing intergenerational conversation which echoed across three centuries.
Translation of adeno-associate viral vectors for delivery of peptide therapeutics with model-informed dosing
Creators: name: Burr, Alexandra
Publisher: name: No Publisher Supplied
Year: 2022

description: Peptide drugs are a life-saving treatment for millions of patients however, they require repeated administration that impacts efficacy, side effects, and costs which limits their use. An alternative solution to injectable peptide drugs is gene therapy, whereby a patients' cells are genetically modified to encode for a peptide drug leading to more durable treatment that can potentially last for years. Our work focused on developing a mathematical and experimental foundation to translate the use of gene therapeutics for peptide hormones. First, a generalized mathematical model of gene therapeutics that encode a secreted protein was developed for this emerging new class of medicines. Using a newly defined matrix of in vitro bioassays, we verified, for the first time, the accuracy of this model to predict experimental drug concentrations in vivo. Then, using parathyroid hormone (PTH) as proof-of-concept, we designed and tested the bioactivity of a first-in-class PTH gene therapy from AAV vector delivery in cell culture and animal studies. Finally, we used synthetic biology techniques to explore a dynamic way to power the secretion of PTH gene therapy using the body's own circadian rhythms. These results demonstrate feasibility for using AAV gene therapy to deliver protein and hormone therapeutics in a dynamic way.
Hans Schmid-Guisan: 1881-1932 Psychiater
Creators: name: Schmid-Guisan, Hans
Publisher: name: ETH Zurich
Year: 1988
Subjects: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
Schmid-Guisan, Hans
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/610
Medical sciences, medicine

description: Handschriften und Autographen der ETH-Bibliothek, 112
William Dunkel 1893-1980
Creators: name: Dunkel, William
Publisher: name: ETH Zurich
Year: 1988
Subjects: subject: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
subject: Dunkel, William
subject: MANUSCRIPT LITERATURE BIBLIOGRAPHIES
subject: info:eu-repo/classification/ddc/720
subject: Architecture
subject: FOS: Civil engineering

description: Handschriften und Autographen der ETH-Bibliothek, 109
title: Μελέτη της επαγγελματικής εξέλιξης των διπλωματούχων μηχανικών παραγωγής & διοίκησης
Creators: name: Κονταξάκης Μιχάλης
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
Raymond Stettler *1915
Creators: name: Stettler, Raymond
Publisher: name: ETH Zurich
Year: 1988
Subjects: subject: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
subject: Stettler, Raymond
subject: MANUSCRIPT LITERATURE BIBLIOGRAPHIES
subject: info:eu-repo/classification/ddc/510
subject: Mathematics
subject: FOS: Mathematics

description: Handschriften und Autographen der ETH-Bibliothek, 99
Late-onset and reversible adrenal insufficiency in survivors of coronavirus disease 2019: results from a 24-month longitudinal study
Creators: name: Sahoo, Saroj
name: Menon, Jayakrishnan C
name: Yadav, Subhash
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420304
subject: General practice

description: The temporal course of hypothalamic-pituitary-adrenal (HPA) dysfunction in patients with corona-virus disease (COVID19) was evaluated in this study.
title: Έρευνα αγοράς για την επέκταση του δικτύου υποκαταστημάτων της Ιονικής Τράπεζας στην Κρήτη
Creators: name: Σφακάκη Ευριδίκη
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
title: Πρόβλεψη της πτώχευσης των επιχειρήσεων με τη βοήθεια των νευρωνικών δικτύων
Creators: name: Σπηλιανάκη Ελένη
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
Investigation of envelope improvements with green roof and green façades for university buildings: a case study of Rutgers’ Richard Weeks Hall
Creators: name: Lubitz, Michelle
Publisher: name: No Publisher Supplied
Year: 2022

description: Building energy modeling (BEM) is a useful tool for identifying design strategies for new buildings and for implementing new energy conservation measures (ECMs) for existing buildings. While many energy conservation measures related to HVAC efficiency and electrical load have been researched, few ECMs relating to the envelope of the building have been studied. The purpose of this thesis is to measure the potential reduction in energy usage of Richard Weeks Hall in response to a variety of envelope ECMs. These ECMs include increasing the roof insulation value, increasing the exterior wall insulation value, incorporating a green roof and incorporating a green façade. The predicted reduction in energy consumption for the green roof and green façade were 10% each, while the predicted reduction in energy consumption for increasing the roof and wall insulation values were approximately 1-2% each. An energy model of Richard Weeks Hall was created using the energy modeling program eQuest. The control (baseline/datum) model was created using the actual construction values and mechanical information of the building. The experimental models simulate a green roof, green façade, and rooves/walls with higher insulation values. Increasing the insulation values reduced the energy consumption of Richard Weeks Hall by approximately .5%. The green roof and green façade reduced the energy consumption of the building by 5.2% and 5.1% respectively. While every ECM resulted in a lower reduction in energy usage than predicted, the reduction from the green roof and green façade is still significant for a university building. Compared to other envelope ECMs, the incorporation of a green roof and green façade is a great opportunity for energy savings in existing and new buidings.
Supplementary document for Ultralow voltage, High-speed, and Energy-efficient Cryogenic Electro-Optic Modulator - 6007778.pdf
Creators: name: Soltani, Mohammad
name: Singh, Anshuman
name: Pintus, Paolo
name: Xie, Weiqiang
name: Ranzani, Leonardo
name: Gustafsson, Martin
name: Tran, Minh
name: Xiang, Chao
name: Peters, Jon
name: Bowers, John
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplementary materials
Extending the Geometric Modulus Principle
Creators: name: Hohertz, Matthew Ryan
Publisher: name: No Publisher Supplied
Year: 2022

description: In a 2011 paper, Kalantari observes that complex polynomials exhibit a certain symmetry with respect to argument at every point. To wit, if the polynomial p(z) has order m as an analytic function whose germ is centered at the point z = z₀, then the complex plane near zo locally splits into 2m sectors of equal angle, alternating between sectors in which |p(z)| > |p(z₀)| and sectors in which |p(z)| < |p(z₀)|. In our subsequent research, we found that this symmetry, which Kalantari formalizes as the Geometric Modulus Principle, is retained (under appropriate modifications) for much larger classes of functions, in particular holomorphic functions as well as harmonic functions of two real variables.This dissertation continues our work in several respects. First, we expand the Geometric Modulus Principle to a broader class of analytic functions, the so-called approximately harmonic functions, that behaves much like the class of harmonic functions with respect to ring operations. We then define the geometric modulus property, enjoyed by a larger-still class of functions, which formalizes the idea of the sign of a function "undulating" in sectors around a point of its domain. If a function has the geometric modulus property and is of order m as an analytic function at a point, then its mᵗʰ derivative with respect to radius is a trigonometric polynomial that behaves like a sine function; we call such trigonometric polynomials sinusoidal, devoting a section of the appendix to their properties. We conclude with some applications of our work and questions for future study.
title: Προτάσεις ανασχεδιασμού παραγωγικής διαδικασίας της εταιρίας Crony  Ε.Π.Ε.
Creators: name: Καραμπάτσα Μαρίνα
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
Additional file 1 of Frequency of sharp wound debridement in the management of diabetes-related foot ulcers: exploring current practice
Creators: name: Nube, Vanessa L
name: Alison, Jennifer A
name: Twigg, Stephen M
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1.
Late-onset and reversible adrenal insufficiency in survivors of coronavirus disease 2019: results from a 24-month longitudinal study
Creators: name: Sahoo, Saroj
name: Menon, Jayakrishnan C
name: Bhatia, Eesh
name: Yadav, Subhash
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420304
subject: General practice

description: The temporal course of hypothalamic-pituitary-adrenal (HPA) dysfunction in patients with corona-virus disease (COVID19) was evaluated in this study.
The Vocational Education Targeted Populations in Texas: JTPA Program Analysis
Creators: name: King, Christopher T.
name: Schexnayder, Deanna T.
Publisher: name: Ray Marshall Center for the Study of Human Resources
Year: 1988
Subjects: Education
Workforce Development

description: The primary purpose of this research project is to provide state-level, postsecondary vocational education planners and administrators with information useful for program planning, coordination, monitoring and evaluation. This report analyzes the types of program activities and services provided and the outcomes resulting from participation in non-Voc Ed efforts by a number of populations targeted for service under the Carl D. Perkins Vocational Education Act of 1984. Programs analyzed include job training efforts funded under the Job Training Partnership Act of 1982 (JTPA) and labor exchange or job placement services provided by the Employment Service (ES) and authorized by the Wagner-Peyser Act of 1933. The detailed analysis focuses on JTPA Title HA programs, with attention also given to the receipt of ES services by JTPA participants in the same time period. Target groups include the economically disadvantaged, males and females, single parents, including parents receiving Aid to Families with Dependent Children (AFDC) benefits as a subset, and persons with limited English proficiency.
title: Μοντέλο γραμμικού προγραμματισμού για προσέγγιση συστήματος εφοδιασμού βιομηχανίας αλουμινίου
Creators: name: Ιωαννίδου Ελένη
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
title: State sovereignty in the 21st century: low-intensity cyber operations and the principles of sovereignty and non-intervention
Creators: name: Hüsch, Pia Katharina
Publisher: name: University of Glasgow
Year: 2023

description: Low-intensity cyber operations do not have physical effects yet constitute a potent mode of interaction, for example, when used to interfere with foreign elections. In the 21st century, inter-state relations have seen an increasing number of these cyber operations. Although there is widespread agreement that international law applies to them, the question remains how exactly existing principles apply. The thesis addresses this question by focussing on two applicable principles, the principles of sovereignty and non-intervention. This examination sheds new light on how the legality of low-intensity cyber operations can be determined by reference to these two principles. This question is addressed through a doctrinal analysis, situated within the context of the relationship of international law and technology which explores how technological advancements have influenced major milestones in the development of international law and state sovereignty. Specifically, the thesis provides a comparative analysis of how sovereignty is understood in domains of international law heavily influenced by technological advancements, including the law of the sea, air space and outer space. With these comparative insights in mind, the subsequent in-depth analysis of the application of sovereignty in cyberspace is structured by identifying three core issues: questions of governance, the principle vs rule debate, and jurisdiction. With respect to the principle of non-intervention, this thesis assesses what makes its application so complex. A case study on foreign election interference illustrates the practical difficulties that arise when applying the requirements of an unlawful intervention to low-intensity cyber operations. Against this backdrop, the thesis concludes that the challenges in applying each principle stem from competing understandings thereof, which precede the cyber debate. However, applying these principles to low-intensity cyber operations at times augments these challenges. Further, the thesis argues that, as state practice in the 2020s has, so far, primarily focused on the principle of sovereignty, non-intervention in cyberspace remains under-explored. Such conclusion is based on an in-depth analysis of the principle of non-intervention that demonstrates that states prefer to retain ambiguity around the application of non-intervention, including in cyberspace. While sovereignty has in contrast gained more attention, the thesis argues that meaningful agreement on its exact application is, in practice, unrealistic given the lack of a common understanding. A more nuanced, explicit regulation of these low-intensity cyber operations is, however, unlikely where states continue to benefit from the legal grey zones surrounding the use of low-intensity cyber operations.
title: Εργονομική ανάλυση εργασίας στο κέντρο ελέγχου κυκλοφορίας των Η.Σ.Α.Π.
Creators: name: Καριανάκης Νίκος
Publisher: name: Technical University of Crete
Year: 1998

description: Μη διαθέσιμο
OEDP Response to OSTP RFI on Equitable Data Engagement and Accountability
Creators: name: Dosemagen, Shannon
name: Hoeberling, Katie
name: Emelia Williams
Publisher: name: Zenodo
Year: 2022
Subjects: open data
data equity
science policy

description: Inclusive, interactive data systems can become a foundation for strengthening environmental equity in communities, especially those dealing with historical or ongoing environmental injustices. Socializing government and the public to the value of community data and the concept of environmental data as a public good will be critical to building equitable and effective data systems. Open dialogue and participatory infrastructure development can help identify the political push points and necessary changes in the social behavior of Federal agency staff and researchers, to ensure adoption and use of inclusive data systems. In September 2022, the White House Office of Science and Technology Policy (OSTP) requested information "on how to best to encourage collaborations between the Federal government and (a) state, local, territorial, and Tribal governments; (b) researchers and research institutions; and (c) local communities that facilitate producing, accessing, and using equitable data." (See RFI here: https://www.federalregister.gov/documents/2022/09/02/2022-19007/request-for-information-equitable-data-engagement-and-accountability). Informed by our research and programming, the Open Environmental Data Project (OEDP) offers recommendations for Federal agencies to better support collaboration with other levels of government, civil society, and the research community around the production and use of equitable data.
BO'LAJAK TEXNOLOGIYA FANI O'QITUVCHILARINI KREATIVLIGINI RIVOJLANTIRISH MAZMUNI
Creators: name: Sayfullayeva, Dilafruz
name: Sharobiddinova, Gulchiroy
Publisher: name: Zenodo
Year: 2023

description: Bo'lajak texnologiya fani o'qituvchilarini kreativligini rivojlantirish mazmuni tahlili, kreativ savodxonlilik, kriativ o'qitish, talabalarning tikuvchilikka oid kreativ rivojlantirish haqida ma'lumotlar bayon etilgan.
A Post-Program, Follow-Up Approach for Postsecondary Vocational Education Students
Creators: name: Gula, Annette
name: King, Christopher T.
Publisher: name: Ray Marshall Center for the Study of Human Resources
Year: 1989
Subjects: Education
Workforce Development

description: In November 1988, North Harris County College District contracted with the Center for the Study of Human Resources (Center), a research facility of the LBJ School for Public Affairs of the University of Texas at Austin, to design, develop and pilot test a post-program follow-up system for postsecondary vocational education students in Texas. The primary objectives of this project were to provide reliable and objective information on student outcomes at both the state and local level while minimizing associated costs; and to test the feasibility of the proposed approach for follow-up data collection. The project was not intended to be a comprehensive data collection system on student progress but rather to offer a source of supplemental data. When linked with data on enrollment and in-program activities, the post-program performance data was intended to provide two-year, postsecondary institutions with an assessment tool for program management and evaluation.
Supplementary document for Generation of vector vortex beams by axially-symmetric sheared polymer network liquid crystals - 6136981.pdf
Creators: name: Lu, Ting-Hua
name: Wang, Yu-Jen
name: Chen, Yu-Fang
name: Lin, Yi-Hsin
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplemental Material
Localised On-Demand Delivery of Nucleic Acid Therapeutics
Creators: name: Sirafim, Catherine
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering
subject: 100709 Nanomedicine
subject: FOS: Nanotechnology
subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology

description: The body naturally orchestrates response to injuries by producing a variety of bioactive cues at precisely coordinated times. However, when this response is hindered –as it is in many diseased states –this results in a lack of healing. Localised on-demand delivery of therapeutic cues that mimic natural signalling profiles can help overcome this and can be achieved by encapsulation of therapeutics in ultrasound-responsive biomaterials. Moreover, housing this delivery system within a regenerative template can further enhance efficacy. This thesis demonstrates the development of a pocketed collagen-based scaffold for the on-demand release of therapeutic nucleic acid-based nanoparticles from alginate hydrogels by application of ultrasound. As multiple therapeutics can be sequentially delivered, this platform can be adapted for applications requiring multi-stage treatments such as osteosarcoma, breast cancer bone metastasis and diabetic foot ulcers. PEI-pdna nanoparticles (for regeneration) and DNA origami nanostructures (cancer treatment), were encapsulated in ionically crosslinked hydrogels and released on-demand with ultrasound (Chapter 2). A mathematical model was developed to simulate the release of PEI-pdnananoparticles, DNA origami nanostructures and mitoxantrone (chemotherapeutic) from alginate hydrogels (Chapter 3), and it was employed to evaluate processes governing drug/hydrogel mass transport and to simulate various ultrasound regimens. Ultrasound-released DNA origami nanostructures, functionalized with doxorubicin, exhibited a therapeutic effect against breast cancer cells (Chapter 4), while the nanostructures remained structurally stable in cell culture media for 4 days. PEI-pdna ultrasound-released nanoparticles remained bioactive and transfected cells; however, protein levels were very low (Chapter 5). Investigations into the effects of the hydrogels on the polyplexes revealed de-stabilization of the PEI-pdna nanoparticles. In Chapter 6, on-demand release of Horse nanostructures from injectable alginate hydrogels embedded in pocketed scaffolds was achieved, and released structures maintained their bioactivity. This work demonstrated the development of a regenerative platform capable of releasing bioactive therapeutic nanoparticles on-demand by application of ultrasound.
Ernst Fiedler: (1861-1954) Privat-Dozent für Mathematik ETH
Creators: name: Fiedler, Ernst Wilhelm
Publisher: name: ETH Zurich
Year: 1988
Subjects: subject: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
subject: Fiedler, Ernst Wilhelm
subject: MANUSCRIPT LITERATURE BIBLIOGRAPHIES
subject: info:eu-repo/classification/ddc/510
subject: Mathematics
subject: FOS: Mathematics

description: Handschriften und Autographen der ETH-Bibliothek, 98
ETHZ Mikrowellen-Laboratorium: Berichte
Creators: name: Wissenschaftshistorische Sammlungen der ETH-Bibliothek
Publisher: name: ETH Zurich
Year: 1988
Subjects: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
Mikrowellenlaboratorium
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/530
Physics

description: Handschriften und Autographen der ETH-Bibliothek, 97
title: Σχεδιασμός και μελέτη απόδοσης μηχανισμού για την ενοποιημένη μετάδοση πληροφορίας τηλεδιάσκεψης MPEG και δεδομένων, σε ασύρματα τοπικά δίστυα IEEE 802.11
Creators: name: Μπρούστης Ιωάννης
Publisher: name: Technical University of Crete
Year: 2003

description: Μη διαθέσιμο
title: POTENTIAL INTERACTIONS OF CANNABINOIDS AND THEIR METABOLITES ON MAJOR DRUG METABOLIZING ENZYMES
title: IMPLICATION ON CO-USE OF TOBACCO AND CANNABIS
titleType: Subtitle
Creators: name: Nasrin, Shamema
Publisher: name: Washington State University
Year: 2022

description: Cannabis-based products have seen increased usage in many parts of the world and in the US, including increases in co-usage with tobacco products. This has led to a need for a more comprehensive understanding of cannabis constituents and their potential for cannabis-drug interactions (CDI) as well as cannabis-tobacco interactions (CTI). While (−)-trans-Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN) are major cannabinoids present in cannabis, the THC metabolites 11-hydroxy-∆9-tetra-hydrocannabinol (11-OH-THC), 11-COO-Δ9-THC (THC-COOH), and 11-COO-Δ9-THC-glucuronide (THC-COO-Gluc) are found in plasma at higher concentrations than cannabinoids in cannabis users. To better understand the potential for CDI and CTI, the inhibitory potential of cannabinoids and metabolites on Phase I [(cytochrome P450 (CYP)] and Phase II [UDP-glucuronosyltransferase (UGT)] enzymes and on the nicotine metabolism pathway were investigated. In vitro assays demonstrated that the major THC metabolites 11-OH-THC and THC-COO-Gluc competitively inhibited CYP2B6, CYP2C9, and CYP2D6. Basic static modeling populated with these data were indicative of the possibility of pharmacokinetic interactions in vivo. Major UGTs were also inhibited by cannabinoids, though no inhibition was observed by THC metabolites. The highest inhibition was observed for CBD against UGTs 1A9, 2B4,1A6, and 2B7.. Potent inhibition of UGT1A9 and UGT2B7 was also demonstrated by THC and CBN. Significant inhibition of nicotine metabolism pathways by CBD and 7-OH-CBD was also observed. CBD and 7-OH-CBD inhibited nicotine metabolism to cotinine and nornicotine in CYP2A6 and CYP2B6-overexpressing microsomes, cotinine metabolism to trans-3’-hydroxycotinine (3HC) in CYP2A6 overexpressing microsomes, and 3HC to 3HC-glucuronide in UGT1A9-overexpressing microsomes. The findings presented in this dissertation suggest that circulating cannabinoids and their metabolites may be inhibiting major CYP and UGT enzymes in users of cannabis products, potentially resulting in CDIs. In addition, cannabinoids like CBD and 7-OH-CBD inhibit nicotine metabolism, potentially decreasing the desire to smoke more cigarettes in smokers who are co-users of cannabis products due to higher endogenous nicotine levels, suggesting that cannabinoids could be important as smoking cessation agents. These findings will help clinicians and researchers identify prescription medications that may have adverse effects when combined with cannabis products.
Karl Cramer: (1831-1901) Professor für allg. Botanik ETH
Creators: name: Cramer, Karl
Publisher: name: ETH Zurich
Year: 1988
Subjects: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
Cramer, Karl
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/580
Botanical sciences

description: Handschriften und Autographen der ETH-Bibliothek, 96
Walkeromyia Paramonov
Creators: name: Ávalos-Hernández, Omar
name: Lucia, Mariano
name: Álvarez, Leopoldo J.
name: Abrahamovich, Alberto H.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Walkeromyia

description: Walkeromyia Paramonov
 Walkeromyia Paramonov, 1934: 22. Type species: Anthrax lurida Walker, 1857, by original designation.
 The reduced fleshy proboscis and labellum, shortened ventral oral recess, wing venation and the bare katatergite in front of the haltere place this genus in the tribe Anthracini, subfamily Anthracinae (Hull 1973). Although Hull (1973) suggested that Walkeromyia should be placed within a separate tribe, Walkeromyini, it remains within Antracini. Walkeromyia differs from other Antracini in its long conical flagellomere and the lack of a hair tuft at the apex of antenna. Characteristics of the genus are the long dense band of slender black scales on the male hind legs, and the generally uniformly brownish yellow wings.
description: Published as part of Ávalos-Hernández, Omar, Lucia, Mariano, Álvarez, Leopoldo J. & Abrahamovich, Alberto H., 2011, Walkeromya plumipes (Philippi) (Diptera: Bombyliidae), a parasitoid associated with carpenter bees (Hymenoptera: Apidae: Xylocopini) in Argentina, pp. 41-46 in Zootaxa 2935 on page 42, DOI: 10.5281/zenodo.206539
title: Ανάπτυξη συστήματος πραγματικού χρόνου για την εξομοίωση φωτοβολταϊκών στοιχείων, βασισμένο σε DSP
Creators: name: Γκάργκας Στυλιανός
name: Ζακόπουλος Αθανάσιος
Publisher: name: Technical University of Crete
Year: 2003

description: Μη διαθέσιμο
Erwin Schrödinger: (1887-1961) Physiker, Entdecker der Wellenmechanik
Creators: name: Schrödinger, Erwin
Publisher: name: ETH Zurich
Year: 1987
Subjects: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
Schrödinger, Erwin
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/530
Physics

description: Handschriften und Autographen der ETH-Bibliothek, 90
August Karolus 1893-1972
Creators: name: Karolus, August
Publisher: name: ETH Zurich
Year: 1988
Subjects: HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
HANDSCHRIFTEN (WERTVOLLE SCHRIFTEN)
Karolus, August
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
MANUSCRIPTS (RARE BOOKS)
info:eu-repo/classification/ddc/621.3
Electric engineering

description: Handschriften und Autographen der ETH-Bibliothek, 93
Quercetin amorphous solid dispersions prepared by hot melt extrusion with enhanced solubility and intestinal absorption
Creators: name: Shi, Xianbao
name: Fan, Na
name: Zhang, Gang
name: Sun, Jin
name: He, Zhonggui
name: Li, Jing
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: The aim of this study was to investigate the effect of amorphous solid dispersions (ASDs) on the dissolution rate and oral bioavailability of Quercetin (Que). First, we prepared the Que ASDs with various excipients using hot-melt extrusion to find the best option. X-ray diffraction (XRD), infrared spectroscopy (IR), and Raman spectroscopy were used to examine the solid formation of Que. Wetting process was studied by contact angle and solution process. The abilities of HPMC to inhibit crystallization and improve membrane permeability were demonstrated by fluorescence spectroscopy, dynamic light scattering analysis, in vitro permeability experiment and pharmacokinetics studies. Que existed as amorphous in solid dispersions, and poloxamer 188 (F68) was the best excipient for improving Que dissolution. Study on ASDs wettability proved Que ASDs improved wetting property in the presence of the F68. Furthermore, Que/F68/HPMC 1/4/3 and 1/5/2 ASDs belonged to drug-controlled diffusion; Que/F68/HPMC 1/6/1 ASDs belonged to drug/carrier-controlled diffusion; Que/F68 1/7 ASDs belonged to carrier-controlled diffusion. Addition of HPMC significantly inhibited the crystallization, improved membrane permeability and promoted drug absorption of compound Que. Que ASDs prepared enhanced solubility and intestinal absorption. Thus, Que ASDs provide a potent and efficacious formulation for Que oral administration.
Was bedeutet Open Science für das künftige Geschäftsmodell von Bibliotheken?
Creators: name: Tochtermann, Klaus
Publisher: name: Zenodo
Year: 2022
Subjects: OAWeekBBB, Open Science, Libraries, Business Models

description: Vortrag in der Reihe Quo vadis offene Wissenschaft. Eine virtuelle Open Access Woche für Berlin-Brandenburg am 17.2.2022.
Josef Wolfgang von Deschwanden 1819-1866
Creators: name: Deschwanden, Joseph Wolfgang <>
Publisher: name: ETH Zurich
Year: 1988
Subjects: Deschwanden, Joseph Wolfgang von
HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/000
Generalities, science

description: Handschriften und Autographen der ETH-Bibliothek, 101
INTO THE UNKNOWN: PREDICTING WHEAT DISEASE RESISTANCE AND SEEDLING EMERGENCE
Creators: name: Merrick, Lance Farley
Publisher: name: Washington State University
Year: 2022
Subjects: subject: Genomic Selection
subject: Seedling Emergence
subject: Stripe Rust
subject: Winter Wheat
subject: Genetics
subject: FOS: Biological sciences
subject: Plant Breeding

description: Winter wheat (Triticum aestivum L.) is the most widely grown cereal grain in Washington state. However, it generally takes 12 years to develop a cultivar from crossing to release, which can limit the ability for rapid improvement of traits. Genomic selection (GS) is posed to increase genetic gains by reducing the generation interval, also known as cycle time, while increasing response to selection. To fully utilize GS in breeding programs we reviewed and proposed implementing a two-part breeding strategy by differentiating population improvement and product development to increase the genetic gain of a breeding program. We then compared GS models for various scenarios for two complex traits, seedling emergence and stripe rust (Puccinia striiformis Westend. f. sp. tritici Erikss.) resistance, using two training populations composed of a diverse association mapping panel and breeding lines that can be used as a guideline for the implementation of GS into breeding programs. We compared GS models for seedling emergence and showed the consistent moderate accuracy of the parametric models indicates little advantage of using non-parametric models within individual years, but the non-parametric models show a slight increase in accuracy when combing years for complex traits. We then compared single-trait and multi-trait genome-wide association (GWAS) models with covariates, and were able to identify many small effect markers, while identifying the large effect markers on chromosome 5A. Stripe rust resistance is controlled by both major and minor resistance genes, and it is recommended to combine both major and minor genes for durable resistance. We compared the accuracy of GS models with major gene and GWAS markers as fixed effects and compared them to marker-assisted selection. The major gene and GWAS markers had only a small to zero increase in prediction accuracy over the base GS models but showed a statistical increase in accuracy using major markers when the mean accuracy decreased. Further, stripe rust resistance phenotypes are commonly skewed due to high levels of resistance. We compared classification and regression models and showed that breeders can use linear and non-parametric regression models within their own breeding lines over combined years to accurately predict skewed phenotypes.
Albert Frey-Wyssling 1900-1988: Diapositive aus dem Nachlass
Creators: name: Frey-Wyssling, Albert
Publisher: name: ETH Zurich
Year: 1988
Subjects: Frey-Wyssling, Albert
PFLANZENPHYSIOLOGIE
DIAPOSITIVE (DOKUMENTENTYP)
BOTANIK
PLANT PHYSIOLOGY
SLIDES (DOCUMENT TYPES)
BOTANY
info:eu-repo/classification/ddc/580
Botanical sciences

description: Handschriften und Autographen der ETH-Bibliothek, 114
OCULAR AND SYSTEMIC METABOLOMIC/GENOMIC DYSREGULATION IN THE VIGABATRIN INDUCED HYPERGABAERGIC STATE
Creators: name: Walters, Dana Christopher
Publisher: name: Washington State University
Year: 2022

description: The antiepileptic agent vigabatrin (VGB; SabrilR) is effective in treating infantile spasms and focal-onset seizures. VGB directly targets the metabolic pathway of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), via irreversible inhibition of GABA-transaminase (GABA-T) and ensuant increase of CNS GABA. VGB is administered as a racemic mixture of the R-(-) and S-(+) isomers; only the S-(+) enantiomer is active. Unfortunately, VGB carries a significant risk of use-limiting ocular toxicity, manifesting as permanent peripheral visual field constriction (pVFC) in a subpopulation of patients. Here we demonstrate that adult VGB-treated mice accumulate the active isomer preferentially in the retina and visual cortex. This accumulation is accompanied by altered amino acid profiles, including retinal GABA and 2-aminoadipic acid (AADA), the latter a glial toxin. Brain amino acid alterations during VGB administration included elevated GABA, β-alanine, carnosine, ornithine, and AADA (the latter in the visual cortex). VGB-induced metabolic abnormalities were compared to those found in the autopsied brain of a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD), which is the enzyme directly following GABA-T and responsible for the final conversion of the GABA carbon skeleton to succinate. Retinal transcriptome analysis in VGB-treated animals revealed dysregulation of signaling, including the pathway of phototransduction. This work provides a tissue-specific platform from which to further evaluate VGB’s mechanism of action for adverse retinal toxicity, and the potential for drug development to mitigate this side effect.
Gabriel Narutowicz 1865-1922
Creators: name: Narutowicz, Gabriel
Publisher: name: ETH Zurich
Year: 1988
Subjects: Narutowicz, Gabriel
BIOGRAPHIEN (LEBEN UND WERK)
WASSERBAU (BAUINGENIEURWESEN)
POLITIK
POLEN (OSTEUROPA). REPUBLIK POLEN
SCHWEIZ (MITTELEUROPA). SCHWEIZERISCHE EIDGENOSSENSCHAFT
BIOGRAPHIES (LIFE AND WORK)
HYDRAULIC ENGINEERING (CIVIL ENGINEERING)
POLITICS
POLAND (EAST EUROPE). REPUBLIC OF POLAND
SWITZERLAND (CENTRAL EUROPE). SWISS CONFEDERATION
info:eu-repo/classification/ddc/620
Engineering & allied operations

description: Handschriften und Autographen der ETH-Bibliothek, 115
Johann Hans Meier *1913
Creators: name: Meier; Johann Hans
Publisher: name: ETH Zurich
Year: 1989
Subjects: Meier; Johann Hans
HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/620
Engineering & allied operations

description: Handschriften und Autographen der ETH-Bibliothek, 117
Judith Herrin, Ravenna. Hauptstadt des Imperiums, Schmelztiegel der Kulturen.
Creators: name: Warland, Rainer
Publisher: name: The Byzantine Review
Year: 2022

description: Judith Herrin, Ravenna. Hauptstadt des Imperiums, Schmelztiegel der Kulturen. Darmstadt: wbg Theiss 2022. 605 S., 32 ungez. S., Tafeln. – ISBN 978-3-8062-4416-8 (€ 39.00 DE)}
description: The Byzantine Review, Bd. 4 (2022)
title: Ποσότητες και χρονική κατανομή των οικιακών απορριμάτων στην περιοχή της Κρήτης
Creators: name: Μπεδρέλης Χριστόδουλος
Publisher: name: Technical University of Crete
Year: 2009

description: Μη διαθέσιμο
Was bedeutet Open Science für das künftige Geschäftsmodell von Bibliotheken Antworten aus der Perspektive der Staatsbibliothek zu Berlin
Creators: name: Altenhöner, Reinhard
Publisher: name: Zenodo
Year: 2022
Subjects: OAWeekBBB, Open Science, Libraries, Business Models

description: Vortrag in der Reihe Quo vadis offene Wissenschaft. Eine virtuelle Open Access Woche für Berlin-Brandenburg am 17.2.2022.
title: Χρήση τύρφης και λιγνίτη για εδαφοβελτιωτικά και οργανοχουμικά λιπάσματα
Creators: name: Αναγνώστου Ελένη
Publisher: name: Technical University of Crete
Year: 2009

description: Μη διαθέσιμο
Martin Huber 1936-
Creators: name: Huber, Martin C. E.
Publisher: name: ETH Zurich
Year: 1989
Subjects: Huber, Martin C. E.
HANDSCHRIFTENVERZEICHNISSE + HANDSCHRIFTENKATALOGE
MANUSCRIPT LITERATURE BIBLIOGRAPHIES
info:eu-repo/classification/ddc/530
Physics

description: Handschriften und Autographen der ETH-Bibliothek, 118
MPEC 2023-M78 : 2016 LY48
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Was bedeutet Open Science für das künftige Geschäftsmodell von Bibliotheken? – Aus der Sicht einer kleineren wissenschaftlichen Spezialbibliothek
Creators: name: Fräßdorf, Mathis
Publisher: name: Zenodo
Year: 2022
Subjects: OAWeekBBB, Open Science, Libraries, Business Models

description: Vortrag in der Reihe Quo vadis offene Wissenschaft. Eine virtuelle Open Access Woche für Berlin-Brandenburg am 17.2.2022.