cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cooperative Inquiry Extended: Creating Technology with Middle School Students with Learning Differences
Creators: name: Foss, Elizabeth
name: Guha, Mona L.
name: Papadatos, Panagis
name: Clegg, Tamara
name: Yip, Jason C.
name: Walsh, Greg
Publisher: name: Maryland Shared Open Access Repository
Year: 2013
Subjects: cooperative inquiry
children
learning disabilities
special education
developing technology

description: Cooperative Inquiry is a method of developing technology in which children and adults are partners in the design process. Cooperative Inquiry is used to empower children in the design of their own technology and to design technology that is specific to children’s needs and wants. As Cooperative Inquiry is continually evolving and expanding, we need to consider how researchers can extend this inclusive design approach to working with populations of children with developmental, behavioral, or learning disabilities. In a semester-long case study, we explored the use of Cooperative Inquiry techniques in a classroom setting with middle school age boys with special learning needs, including mild to moderate autism, dyslexia, and attention deficits. The participating class of 10 boys ages 11-12 designed a browser-based computer game using Cooperative Inquiry techniques over the course of seven design sessions. Findings include that Cooperative Inquiry techniques require few modifications for use by the population of children with special learning needs. The recommendations to employ Cooperative Inquiry in a special education classroom include modifications to session structure and planning, adding informal time during the sessions, maintaining a high adult-to child ratio, giving instructions using many modalities, and planning for high engagement. Through this work, we believe that Cooperative Inquiry’s applicability is broadened to a new population in a classroom setting, and can be used to design more effective technologies for populations of children with special leaning needs in the future.
Impact of different estimations of the background-error covariance matrix on climate reconstructions based on data assimilation
Creators: name: Valler, Veronika
name: Franke, Jörg
name: Brönnimann, Stefan
Publisher: name: Copernicus Publications
Year: 2019
Subjects: 300 Social sciences, sociology & anthropology
550 Earth sciences & geology
910 Geography & travel

description: Data assimilation has been adapted in paleoclimatology to reconstruct past climate states. A key component of the assimilation system is the background-error covariance matrix, which controls how the information from observations spreads into the model space. In ensemble-based approaches, the background-error covariance matrix can be estimated from the ensemble. Due to the usually limited ensemble size, the background-error covariance matrix is subject to the so-called sampling error. We test different methods to reduce the effect of sampling error in a published paleo data assimilation setup. For this purpose, we conduct a set of experiments, where we assimilate early instrumental data and proxy records stored in trees, to investigate the effect of 1) the applied localization function and localization length scale; 2) multiplicative and additive inflation techniques; 3) temporal localization of monthly data, which applies if several time steps are estimated together in the same assimilation window. We find that the estimation of the background-error covariance matrix can be improved by additive inflation where the background-error covariance matrix is not only calculated from the sample covariance, but blended with a climatological covariance matrix. Implementing a temporal localization for monthly resolved data also led to a better reconstruction.
FACIT PD: A Framework for Analysis and Creation of Intergenerational Techniques for Participatory Design
Creators: name: Walsh, Greg
name: Foss, Elizabeth
name: Yip, Jason C.
name: Druin, Allison
Publisher: name: Maryland Shared Open Access Repository
Year: 2013
Subjects: children
design
design techniques
design methods

description: In this paper, we present a framework that describes commonly used design techniques for Participatory Design with children. Although there are many currently used techniques for designing with children, researchers working in differing contexts and in a changing technological landscape find themselves facing difficult design situations. The Octoract framework presented in this paper can aid in choosing existing design techniques or in developing new techniques regardless of the stage in the design cycle, the technology being developed, or philosophical approach to design method. The framework consists of eight dimensions, concerning the design partners, the design goal, and the design technique. The partner dimensions are design experience of the participant and partner ability. The design goal dimensions are design space and maturity of design. The technique dimensions include: cost, mobility of technique, and technology level. Two cases will be presented which describe new techniques and two case of an existing technique.
Psychometrische Eigenschaften einer deutschsprachigen Übersetzung des Mental Toughness Inventory (MTI-D)
Creators: name: Schmid, Jürg
name: Steiner, Silvan
name: Rechsteiner Rensch, Manuela
name: Middleton, Cory
name: Seiler, Roland
Publisher: name: Hogrefe
Year: 2018
Subjects: 790 Sports, games & entertainment

description: Das Mental Toughness Inventory (MTI; Middleton, Martin & Marsh, 2011) ist ein Selbstbeurteilungsinstrument zur Erfassung von 12 Facetten mentaler Stärke im Sport oder anderen leistungsbezogenen Kontexten. Ins Deutsche übersetzt, wurde das MTI-D an einer deutschsprachigen Stichprobe (N = 1 122), davon n = 914 Athletinnen und Athleten und n = 208 Studierende der Sportwissenschaft aus 41 Sportarten hinsichtlich Faktorstruktur, Messinvarianz, Reliabilität, Konstrukt und Kriteriumsvalidität untersucht. Entsprechend der theoretischen Konzeption ergaben Bifaktorenanalysen für das MTI-D eine Struktur mit einem gemeinsamen Faktor und 12 spezifischen Faktoren. Die Reliabilität (ω) der Gesamtskala und der Subskalen lag zwischen .81 und .98, während die Werte für omega hierarchical subscale tiefer lagen (.07 ≤ ωHS ≤ .77). Der globale und die spezifischen Faktoren korrelierten hypothesenkonform mit dem Engagement und Leistungsniveau im Sport sowie dem Test of Performance Strategies (TOPS-D; Schmid, Birrer, Kaiser & Seiler, 2010) zur Erfassungmentaler Strategien im Sport. Zwar könnten einzelne Faktoren optimiert werden, doch es liegen Hinweise darauf vor, dass mit dem MTI-D mentale Stärke reliabel und valide erfasst werden kann. The Mental Toughness Inventory (MTI; Middleton, Martin & Marsh, 2011) is a self-description questionnaire measuring 12 facets of mental toughness in sports or other performance-oriented contexts. Translated into German, the MTI-D was analysed with respect to its factorial structure, measurement invariance, reliability, construct validity, and criterion validity using a German-speaking sample of N = 1 122 individuals including n = 914 athletes and n = 208 sport science students involved in 41 different sports. In line with the theoretical conception of the MTI and using a (bifactor) exploratory and confirmatory structural equation modelling framework, the analyses of the MTI-D yielded a factor structure with one general factor and 12 domain-specific factors. The results supported measurement invariance of the MTI-D across gender and age. Omega estimates of composite reliability (ω) for the global factor and the domain-specific factors ranged between .81 and .91, while omega hierarchical subscale was much lower (.07 ≤ ωHS ≤ .77). The MTI-D factors correlated in predictable ways with degree of sport involvement, level of achievement in sport, and the Test of Performance Strategies (TOPS-D; Schmid, Birrer, Kaiser & Seiler, 2010), an instrument measuring mental strategies in sports. Despite that some specific factors await further refinement, there is preliminary evidence that the MTI-D can be used as a reliable and valid questionnaire for assessing mental toughness.
Atmospheric characterization of the super-Jupiter HIP 99770 b with KPIC
Creators: name: Zhang, Yapeng
name: Xuan, Jerry W.
name: Mawet, Dimitri
name: Wang, Jason J.
name: Hsu, Chih-Chun
name: Ruffio, Jean-Bapiste
name: Knutson, Heather A.
name: Inglis, Julie
name: Blake, Geoffrey A.
name: Chachan, Yayaati
name: Horstman, Katelyn
name: Baker, Ashley
name: Bartos, Randall
name: Calvin, Benjamin
name: Cetre, Sylvain
name: Delorme, Jacques-Robert
name: Doppmann, Greg
name: Echeverri, Daniel
name: Finnerty, Luke
name: Fitzgerald, Michael P.
name: Jovanovic, Nemanja
name: Liberman, Joshua
name: López, Ronald A.
name: Morris, Evan
name: Pezzato, Jacklyn
name: Sappey, Ben
name: Schofield, Tobias
name: Skemer, Andrew
name: Wallace, J. Kent
name: Wang, Ji
name: Ó, Clarissa R. Do
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Young, self-luminous super-Jovian companions discovered by direct imaging provide a challenging test of planet formation and evolution theories. By spectroscopically characterizing the atmospheric compositions of these super-Jupiters, we can constrain their formation histories. Here we present studies of the recently discovered HIP 99770 b, a 16 MJup high-contrast companion on a 17 au orbit, using the fiber-fed high-resolution spectrograph KPIC (R~35,000) on the Keck II telescope. Our K-band observations led to detections of H2O and CO in the atmosphere of HIP 99770 b. We carried out free retrieval analyses using petitRADTRANS to measure its chemical abundances, including the metallicity and C/O ratio, projected rotation velocity (vsini), and radial velocity (RV). We found that the companion's atmosphere has C/O=0.55(-0.04/+0.06) and [M/H]=0.26(-0.23/+0.24) (1σ confidence intervals), values consistent with those of the Sun and with a companion formation via gravitational instability or core accretion. The projected rotation velocity < 7.8 km/s is small relative to other directly imaged companions with similar masses and ages. This may imply a near pole-on orientation or effective magnetic braking by a circumplanetary disk. In addition, we added the companion-to-primary relative RV measurement to the orbital fitting and obtained updated constraints on orbital parameters. Detailed characterization of super-Jovian companions within 20 au like HIP 99770 b is critical for understanding the formation histories of this population.
description: 18 pages, 5 figures, accepted to AJ
Critical Illness Myopathy: Glucocorticoids revisited?
Creators: name: Z'Graggen, Werner J.
name: Schefold, Joerg C.
Publisher: name: Blackwell Publishing
Year: 2019
Subjects: 610 Medicine & health

description: Over the past decades, survival rates of critical illness have constantly increased. As a consequence, the incidences of important complications of intensive care unit (ICU) treatment become more and more prevalent. Critical illness myopathy (CIM) belongs to one of the most frequent neuromuscular complications and its presence is associated with prolonged need for mechanical ventilation and ICU stay, increased morbidity and mortality 1,2. High-dose glucocorticoid (GC) treatment was early after the initial description of CIM postulated to be a major triggering factor for the development of the disease. In the current issue of Acta Physiologica, Akkad et al. investigate the effects of two GC drugs (prednisolone and a new dissociative GC termed vamorolone) on CIM development3. This article is protected by copyright. All rights reserved.
Additional file 2 of DNA methylation variations underlie lettuce domestication and divergence
Creators: name: Cao, Shuai
name: Sawettalake, Nunchanoke
name: Li, Ping
name: Fan, Sheng
name: Shen, Lisha
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2.
title: Die Implementierung der Sprachstandsdiagnostik & Sprachförderung im vorschulischen Bildungsbereich
Creators: name: Hatzigmoser, Desiree
Year: 2010

description: Das österreichische Bildungssystem stellt bereits beim Eintritt in die Schule gewisse Anforderungen an ein 6- jähriges Kind. Diese, u.a. auch gesetzlich festgelegten Anforderungen, beziehen sich zum Beispiel auf die Kompetenz zur Anwendung der Sprache Deutsch als Bildungssprache. Doch nicht alle Kinder haben bis zu ihrem Schuleintritt ein ausreichendes Kompetenzniveau in ihrer Erst- oder Zweitsprache Deutsch erworben. Bildungspolitische Forderungen trugen nun dazu bei, um sprachliche Defizite bei Kindern im vorschulischen Alter zu kompensieren. Durch die, daraus resultierende Einführung des „Wiener Fördrmodells 1+1“, wurden im Jahre 2008 daher erstmals bundesweit die Projekte der „Frühen sprachlichen Förderung“ und der „Frühen Sprachstandsfeststellung“ implementiert. Im Zuge dessen wurden (vom BIFIE) die Sprachstandsbeobachtungsbögen BESK 4-5 und SSFB 4-5, mit der theoretischen Fundierung eines Sprachkompetenzmodells, entwickelt und in die pädagogische Praxis der Wiener Kindergärten integriert. Der Einsatz der Beobachtungsbögen sowie die Durchführung der „Frühen sprachlichen Förderung“ konnte in den Kindergärten und Schulen gelungen erfolgen. Die teilweise unzureichenden Ressourcen in den Kindergärten und Schulen stellten bisher jedoch meist eine gewisse Schwierigkeit dar, um die bildungspolitischen Forderungen ausreichend implementieren zu können. Doch durch erhöhten individuellen Einsatz der Pädagoginnen und Pädagogen ist es gelungen, das „Wiener Fördermodell 1+1“- dessen Intentionen entsprechend- zu implementieren. Dieses Fördermodell ist somit ein Versuch, Kindern Chancengerechtigkeit beim Übergang ins Schulsystem zu ermöglichen!
Supplementary File
Creators: name: Gasteiger, Chiara
Publisher: name: figshare
Year: 2022
Subjects: subject: 170106 Health, Clinical and Counselling Psychology
subject: FOS: Psychology
subject: 170105 Gender Psychology
subject: 170102 Developmental Psychology and Ageing

description: Supplementary file for scoping review exploring community-based support, initiatives, programmes, and practices that aim to improve mental health/wellbeing, used by older SGD adults.
Additional file 3 of DNA methylation variations underlie lettuce domestication and divergence
Creators: name: Cao, Shuai
name: Sawettalake, Nunchanoke
name: Li, Ping
name: Fan, Sheng
name: Shen, Lisha
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 3. Review history.
heatplot: Stata module to create heat plots and hexagon plots
Creators: name: Jann, Ben
Publisher: name: Boston College Department of Economics
Year: 2019
Subjects: 300 Social sciences, sociology & anthropology

description: heatplot creates heat plots from variables or matrices. One example of a heat plot is a two-dimensional histogram in which the frequencies of combinations of binned Y and X are displayed as rectangular (or hexagonal) fields using a color gradient. Another example is a plot of a trivariate distribution where the color gradient is used to visualize the (average) value of Z within bins of Y and X. Yet another example is a plot that displays the contents of a matrix, say, a correlation matrix or a spacial weights matrix, using a color gradient.
title: Kompetenzen von Frühförderern und Frühförderinnen in der Elternarbeit mit Familien mit Migrationshintergrund
Creators: name: Flügl, Liliane
Year: 2010

description: Aufgrund weltweit zunehmender Migrationsbewegungen und dem dadurch höheren Anteil an Menschen aus unterschiedlichen Herkunftsländern in verschiedenen Berufsfeldern sowie als KlientInnen diverser gesundheitlicher und sozialer Dienstleistungen, findet generell eine stärkere Auseinandersetzung mit der Thematik um interkulturelle Interaktionen statt, und es wird versucht, dabei auftretende Probleme zu verstehen und zu bewältigen. Frühförderung, welche einen spezifischen Ausschnitt aus den vielfältigen sozialen und gesundheitlichen Einrichtungen darstellt und ebenso eine Zunahme an KlientInnen mit Migrationshintergrund aufweisen kann, wird in dieser Diplomarbeit mit Bezug auf Österreich näher beleuchtet. Das Erkenntnisinteresse dieser Arbeit richtet sich auf die Zusammenarbeit zwischen FrühförderInnen und den Erziehungsberechtigten des Kindes. Dabei werden u. a. Schwierigkeiten, mit denen FrühförderInnen konfrontiert werden, aufgezeigt, und es wird versucht herauszufinden, welcher spezifischen Kompetenzen Frühförderer und Frühförderinnen in der Arbeit mit Eltern mit Migrationshintergrund bedürfen, um die Zusammenarbeit mit ihnen zu stärken, sodass letzten Endes das Kind in seiner Entwicklung bestmöglich gefördert werden kann.
description: On account of worldwide increasing flows of migration, a large number of people from different countries are employed in various fields of occupation and are clients of diverse health and social services, which has caused an intensified discussion concerning intercultural interaction and coinciding problems. Efforts have been made to understand these problems and to cope with them. Early childhood intervention, a specific section of the social and health institutions, is offered to children with disabilities and their parents. This thesis concentrates on the work of early intervention specialists and their cooperation with the parents of such children in Austria. It shows the difficulties und problems they have to face, and it tries to find the relevant competences early intervention specialists should have or acquire in order to be able to work effectively with the parents and to contribute to the development of children with disabilities.
Benchmarking of reactive transport codes for 2D simulations with mineral dissolution–precipitation reactions and feedback on transport parameters
Creators: name: Poonoosamy, J.
name: Wanner, Christoph
name: Alt-Epping, Peter
name: Águila, J. F.
name: Samper, J.
name: Montenegro, L.
name: Xie, M.
name: Su, D.
name: Mayer, K. U.
name: Mäder, Urs
name: Van Loon, L. R.
name: Kosakowski, G.
Publisher: name: Springer
Year: 2018
Subjects: 550 Earth sciences & geology

description: Porosity changes due to mineral dissolution–precipitation reactions in porous media and the resulting impact on transport parameters influence the evolution of natural geological environments or engineered underground barrier systems. In the absence of long-term experimental studies, reactive transport codes are used to evaluate the long-term evolution of engineered barrier systems and waste disposal in the deep underground. Examples for such problems are the long-term fate of CO2 in saline aquifers and mineral transformations that cause porosity changes at clay–concrete interfaces. For porosity clogging under a diffusive transport regime and for simple reaction networks, the accuracy of numerical codes can be verified against analytical solutions. For clogging problems with more complex chemical interactions and transport processes, numerical benchmarks are more suitable to assess model performance, the influence of thermodynamic data, and sensitivity to the reacting mineral phases. Such studies increase confidence in numerical model descriptions of more complex, engineered barrier systems. We propose a reactive transport benchmark, considering the advective–diffusive transport of solutes; the effect of liquid-phase density on liquid flow and advective transport; kinetically controlled dissolution–precipitation reactions causing porosity, permeability, and diffusivity changes; and the formation of a solid solution. We present and analyze the results of five participating reactive transport codes (i.e., CORE2D, MIN3P-THCm, OpenGeoSys-GEM, PFLOTRAN, and TOUGHREACT). In all cases, good agreement of the results was obtained.
Efforts for aligning the Brazilian Height System to the International Height Reference System
Creators: name: Freitas, Sílvio R. C. De
name: Ferreira, Vagner G.
name: Luz, Roberto T.
Publisher: name: Karlsruhe
Year: 2018

description: The International Height Reference System (IHRS) consolidated the idea of a world height system (WHS) according to the IAG Resolution 1/2015. Since 2000, the majority of activities related to the modernization of the Brazilian Height System (BHS) has referred to a physical meaning for the heights and have linked two existing vertical datums in the country to a same equipotential surface. Today, these activities relate to the BHS and its realization by the Brazilian Vertical Reference Network (BVRN) agrees with the IHRS precepts. In this context, the main developed activities related to BHS/BVRN and achieved goals are described in this work.
Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis [version 2; peer review: 3 approved].
Creators: name: Wandeler, Gilles
name: Buzzi, Marta
name: Anderegg, Nanina
name: Sculier, Delphine
name: Béguelin, Charles
name: Egger, Matthias
name: Calmy, Alexandra
Publisher: name: F1000 Research Ltd
Year: 2019
Subjects: 610 Medicine & health
360 Social problems & social services

description: Dolutegravir-containing maintenance therapy is a promising simplification strategy for virologically suppressed HIV-infected individuals. However, most of the available data to inform this strategy come from small, uncontrolled studies. We estimated the proportion of HIV-infected patients experiencing virological failure (VF) and developing drug resistance on dolutegravir (DTG)-based maintenance therapy. We searched Medline, Embase, Cochrane Central, Web of Science, and conference abstracts for studies assessing VF on DTG-based maintenance therapy. Studies including ≥5 adults with an undetectable viral load on antiretroviral therapy (ART) who switched to a DTG-based mono- or dual therapy were included. Pooled proportions of VF were estimated using random-intercept logistic meta-regression and acquired drug resistance mutations described for each strategy. : Of 1719 studies considered, 21 met our selection criteria, including seven interventional and 14 observational studies. Eight studies including 251 patients assessed VF on DTG monotherapy and fourteen studies including 1670 participants VF on dual therapy. The participant's median age ranged from 43 to 63 years, their median nadir CD4 count from 90 to 399 cells/µl, and 27.6% were female. The proportion of participants experiencing VF on DTG-monotherapy was 3.6% (95% confidence interval [CI] 1.9-6.7) at 24 weeks and 8.9% (95% CI 4.7-16.2) at 48 weeks. Resistance mutations developed in seven (3.6%) participants on DTG-monotherapy. Among patients on dual therapy, ten (0.7%, 95% CI 0.4-1.3) experienced VF by 48 weeks and none developed resistance to DTG. In adjusted analyses, VF at 24 weeks was less likely on dual therapy than on monotherapy (adjusted odds ratio: 0.10, 95% CI 0.03-0.30). Whereas VF is relatively common on DTG maintenance monotherapy, DTG-based dual therapy appears to be a promising simplification strategy for individuals with a suppressed HIV viral load on triple-ART.
The Genesis of Humanity: Tracing the Deepest Lineages in Modern DNA to Y-Haplogroup A0000 and mtDNA L0
Creators: name: Ramon Moses
Publisher: name: Zenodo
Year: 2024
Subjects: subject: A0000
subject: Ancient DNA
subject: mtDNA Haplogroup L0
subject: mtDNA
subject: Y DNA
subject: Ramon Moses
subject: Quantum computers
subject: Quantum physics
subject: Quantum Theory
subject: Quantum Dots/economics
subject: Quantum Dots/history
subject: Quantum Dots/supply & distribution
subject: Quantum Theory/history
subject: Quantum Dots/standards
subject: Quantum Dots/toxicity
subject: Quantum Dots/therapeutic use
subject: Quantum chemistry
subject: Quantum field theory

description: This paper explores the profound discovery of an individual, Ramon Moses, who carries both Y-DNA haplogroup A0000 and mitochondrial DNA (mtDNA) haplogroup L0, the deepest known paternal and maternal lineages in modern humans. These lineages predate Genetic Adam (~232,000 years ago) and Mitochondrial Eve (~200,000 years ago), spanning a combined timeline of over 432,000 years. Uniquely, Ramon Moses’s DNA embodies the genetic origins of both Adam and Eve, representing the split and eventual recombination of ancient male and female lineages within one individual. This discovery offers an unprecedented opportunity to examine the genetic and evolutionary continuity of Homo sapiens, bridging ancient ancestry with modern populations.
What makes a strawman acceptable? Three experiments assessing linguistic factors
Creators: name: Schumann, Jennifer
name: Zufferey, Sandrine
name: Oswald, Steve Robert Arthur
Publisher: name: Elsevier
Year: 2019
Subjects: 410 Linguistics
440 French & related languages

description: A straw man is a form of fallacious argument that involves the distortion of an opponent's view in order to make it more extreme and therefore less acceptable, thus easier to attack. In three experiments, we assess linguistic factors that may influence the acceptability of straw men for addressees. In Experiment 1, we demonstrate that a straw man is more acceptable when the speaker's argument is attacked rather than his standpoint. In Experiment 2, we show that a straw man is more acceptable when it contains two arguments that are simply juxtaposed rather than linked by a causal connective indicating attributed content (i.e. the French puisque). In Experiment 3, we find that a straw man is more acceptable when it echoes the speaker's explicit rather than implicit meaning. Taken together, these experiments strongly indicate that the formulation of a straw man has an impact on its perceived acceptability. Our results thus open a new avenue of inquiry for studies assessing the role of linguistic factors on the acceptability of fallacies.
Additional file 1 of Analysis of satisfaction levels and perceptions of clinical competency: a mixed method study on objective structured clinical examinations in undergraduate dental students
Creators: name: Ahmed, Naseer
name: Aziz, Samiya
name: Jouhar, Rizwan
name: Rehmat, Muneeba
name: Maqsood, Afsheen
name: Nadeem, Resham
name: Magsi, Laraib
name: Heboyan, Artak
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Cervical cancer risk in women living with HIV across four continents: A multicohort study.
Creators: name: Rohner, Eliane
name: Bütikofer, Lukas
name: Schmidlin, Kurt
name: Sengayi, Mazvita
name: Maskew, Mhairi
name: Giddy, Janet
name: Taghavi, Katayoun
name: Moore, Richard D
name: Goedert, James J
name: Gill, M John
name: Silverberg, Michael J
name: D'Souza, Gypsyamber
name: Patel, Pragna
name: Castilho, Jessica L
name: Ross, Jeremy
name: Sohn, Annette
name: Bani-Sadr, Firouze
name: Taylor, Ninon
name: Paparizos, Vassilios
name: Bonnet, Fabrice
name: Verbon, Annelies
name: Vehreschild, Jörg Janne
name: Post, Frank A
name: Sabin, Caroline
name: Mocroft, Amanda
name: Dronda, Fernando
name: Obel, Niels
name: Grabar, Sophie
name: Spagnuolo, Vincenzo
name: Quiros-Roldan, Eugenia
name: Mussini, Cristina
name: Miro, José M
name: Meyer, Laurence
name: Hasse, Barbara
name: Konopnicki, Deborah
name: Roca, Bernardino
name: Barger, Diana
name: Clifford, Gary M
name: Franceschi, Silvia
name: Egger, Matthias
name: Bohlius, Julia
Publisher: name: Wiley-Blackwell
Year: 2020
Subjects: 610 Medicine & health
360 Social problems & social services

description: We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person-years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382-523), 136 in Latin America (95% CI: 85-219), 76 in North America (95% CI: 48-119) and 66 in Europe (95% CI: 57-77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27-4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73-16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37-1.71). Overall, ICC rates increased with age (>50 years vs. 16-30 years, aHR: 1.57, 95% CI: 1.03-2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15-1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer-related health inequities.
Additional file 2 of Analysis of satisfaction levels and perceptions of clinical competency: a mixed method study on objective structured clinical examinations in undergraduate dental students
Creators: name: Ahmed, Naseer
name: Aziz, Samiya
name: Jouhar, Rizwan
name: Rehmat, Muneeba
name: Maqsood, Afsheen
name: Nadeem, Resham
name: Magsi, Laraib
name: Heboyan, Artak
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Combination of cell transplantation and glial cell line-derived neurotrophic factor-secreting encapsulated cells in Parkinson's disease.
Creators: name: Widmer, Hans Rudolf
Publisher: name: Medknow
Year: 2018
Subjects: 610 Medicine & health

description: A major limitation of cell transplantation for Parkinson's disease (PD) is the mediocre survival of the grafted cells. Facilitating graft survival may improve the functional outcomes of the transplanted cells. Here, we discuss our observations that combination of rat fetal ventral mesencephalic (VM) tissue and encapsulated cells that secrete glial cell line-derived neurotrophic factor (GDNF) enhanced graft function in an animal model of PD. We described significant 2-fold increase in the number of tyrosine hydroxylase immunoreactive (TH-ir) cells per graft, as well as 1.7-fold and 9-fold increments in TH-ir fiber outgrowth into the host brain and toward the capsule with combined transplants and GDNF capsules as opposed to the VM transplants and mock-capsule group. These findings demonstrate that encapsulated GDNF-secreting cells improve graft survival that may optimize functional benefits for the treatment of PD.
National and international collaboration to facilitate human genomics data sharing in Australia: The Human Genomes Platform Project
Creators: name: Shadbolt, Marion
name: Boughtwood, Tiffany
name: Christiansen, Jeff
name: Copty, Joe
name: Cowley, Mark
name: Davies, Kylie
name: Downton, Matthew
name: Druken, Kelsey
name: Evans, Ben
name: Gaff, Clara
name: Gilbert, Andrew
name: Hall, Christina
name: Hofmann, Oliver
name: Holliday, Jessica
name: Kaplan, Warren
name: Koufariotis, Ross
name: Kummerfeld, Sarah
name: Leonard, Conrad
name: Lin, Angela
name: Lonie, Andrew
name: Marks, Heath
name: Siobhann  McCafferty
name: Monro, David
name: Patterson, Andrew
name: Pearson, John
name: Pope, Bernard
name: Shyamsundar Ravishankar
name: Reisinger, Florian
name: Robinson, Andrew
name: Lin, Victor San Kho
name: Scullen, John
name: Syed, Mustafa
name: Taouk, Kamile
name: Treloar, Andrew
name: Jingbo Wang
name: Wong-Erasmus, Marie
name: Wood, Scott
Publisher: name: F1000 Research Limited
Year: 2022

description: The Human Genomes Platforms Project (HGPP) aims to leverage best practice technologies and global standards to accelerate FAIR human genomics data sharing in Australia. Involving Australia’s human genomics research leaders, along with national computing infrastructure partners, the HGPP will break down silos and facilitate the deployment of much needed genomic data sharing infrastructure throughout Australia. The main project themes are: virtual cohort assembly; data access committee automation; federated identity and access management; data and metadata archiving; and documentation and training. Each has strong parallels with existing and developing ELIXIR themes, platforms and communities including the federated human data community, interoperability, REMS, AAI and training. We are also investigating emerging GA4GH standards including Beacon v2 and Passports. Here we introduce the HGPP, describe our achievements to date, outline our upcoming plans for the project and how they align with the ELIXIR programme.
Federated EGA Updates in 2022
Creators: name: Freeberg, Mallory
name: Curwin, Amy
Publisher: name: F1000 Research Limited
Year: 2022

description: The Federated European Genome-phenome Archive (FEGA) is a distributed network aimed at enabling sharing of human genomic, phenotypic, and clinical data and metadata with approved researchers world-wide, in compliance with national data protection regulations. FEGA has been envisioned and designed based on the existing EGA Elixir Core Data Resource and with active participation of several ELIXIR nodes and alignment with other transnational data sharing initiatives. In the last year, several advances to the network have been produced and the work raised a huge interest within the ELIXIR community. This talk provides an update on the state of the art of FEGA and major milestones reached in 2022.
MRI Metal Artifact Reduction Sequence for Auditory Implants: First Results with a Transcutaneous Bone Conduction Implant
Creators: name: Wimmer, Wilhelm
name: Hakim, Arsany
name: Kiefer, Claus
name: Pastore-Wapp, Manuela
name: Anschütz, Lukas Peter
name: Caversaccio, Marco
name: Wagner, Franca
Publisher: name: Karger
Year: 2019
Subjects: 610 Medicine & health

description: Objective: Magnetic resonance imaging (MRI) is often limited in patients with auditory implants because of the presence of metallic components and magnets. The aim of this study was to evaluate the clinical usefulness of a customized MRI sequence for metal artifact suppression for patients with implants in the temporal bone region, specifically patients with a transcutaneous bone conduction implant. Methods: Two whole head specimens were unilaterally implanted with a transcutaneous bone conduction implant. MRI examinations with and without a primarily self-build sequence (SEMAC-VAT WARP) for metal artifact suppression were performed. The diagnostic usefulness of the acquired MRI scans was rated independently by two neuroradiologists. The sequence was also used to acquire postimplantation follow-up MRI in a patient with a transcutaneous bone conduction implant. Results: The customized SEMAC-VAT WARP sequence significantly improved the diagnostic usefulness of the postimplantation MRIs. The image acquisition time was 12 min and 20 s for the T1-weighted and 12 min and 12 s for the T2-weighted MRI. There was good agreement between the two blinded raters (Cohen’s κ = 0.61, p < 0.001). Conclusion: The sequence for metal artifact reduction optimized in Bern enables MRI at 1.5 T in patients with active transcutaneous bone conduction implants without sacrificing diagnostic imaging quality. Particularly on the implanted side, imaging of intracranial and supra- and infratentorial brain pathologies is clinically more valuable than standard diagnostic MRI without any artifact reduction sequences.
Additional file 3 of Analysis of satisfaction levels and perceptions of clinical competency: a mixed method study on objective structured clinical examinations in undergraduate dental students
Creators: name: Ahmed, Naseer
name: Aziz, Samiya
name: Jouhar, Rizwan
name: Rehmat, Muneeba
name: Maqsood, Afsheen
name: Nadeem, Resham
name: Magsi, Laraib
name: Heboyan, Artak
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 3
Diurnal cycle of short-term fluctuations of integrated water vapour above Switzerland
Creators: name: Hocke, Klemens
name: Bernet, Leonie Anna Luisa
name: Hagen, Jonas
name: Murk, Axel
name: Renker, Matthias
name: Mätzler, Christian
Publisher: name: European Geosciences Union
Year: 2019
Subjects: 620 Engineering

description: The TROpospheric WAter RAdiometer (TROWARA) continuously measures integrated water vapour (IWV) with a time resolution of 6 seconds at Bern in Switzerland. During summer, we often see that IWV has temporal fluctuations during daytime while the night-time data are without fluctuations. The data analysis is focused on the year 2010 where TROWARA has a good data quality without data gaps. We derive the spectrum of the IWV fluctuations in the period range from about 1 to 100 min. The FFT spectrum with a window size of 3 months leads to a serious underestimation of the spectral amplitudes of the fluctuations. Thus, we apply a band pass filtering method to derive the amplitudes as a function of period Tp. The amplitudes are proportional to Tp0.5. Another method is the computation of the moving standard deviation with time window lengths from about 1 to 100 min. Here, we get similar results as for the band pass filtering method. At all periods, the IWV fluctuations are strongest during summer while they are smallest during winter. We derive the diurnal variation of the short-term IWV fluctuations by applying a moving standard deviation with a window length of 10 min. The daily cycle is strongest during the summer season with standard deviations up to 0.22 mm at about 14:00 CET. The diurnal cycle disappears during winter time. Using the meteorological weather station at Bern, we derive the diurnal cycle of the short-term fluctuations of the specific kinetic energy ek. Since these data have a temporal resolution of 10 min, we apply a 20 min-moving standard deviation. The derived short-term ek fluctuations can be regarded as a proxy of turbulent kinetic energy (TKE). During summer time, the 20 min-moving standard deviation of ek increases during daytime and has a similar diurnal cycle like the short-term IWV fluctuations. Thus, we conclude that the diurnal cycle of the short-term IWV fluctuations is caused by turbulence associated with large convective heating during daytime in summer.
GPU-powered AI in docker-based Jupyterlab on Galaxy Europe
Creators: name: Anup Kumar
name: Cuccuru, Gianmauro
name: Grüning, Björn
Publisher: name: F1000 Research Limited
Year: 2022

description: An open-source, docker-based, and GPU-enabled Jupyterlab [1] notebook has been developed running on the public compute infrastructure of Galaxy Europe for rapid prototyping and developing end-to-end artificial intelligence (AI) projects. Using this Jupyterlab notebook, long-running training jobs can be executed remotely on Galaxy’s infrastructure.
Outsourcing der Informationsverarbeitung im Mittelstand: Test eines multitheoretischen Kausalmodells
Creators: name: Dibbern, Jens
name: Heinzl, Armin Horst
Publisher: name: Springer Gabler
Year: 2009
Subjects: 000 Computer science, knowledge & systems
300 Social sciences, sociology & anthropology
330 Economics
600 Technology
650 Management & public relations

description: In dem vorliegenden Beitrag wird die Situation des Outsourcings der Informationsverarbeitung (IV) in einer für den Mittelstand spezifischen Branche beleuchtet. Auf Basis theoretischer Überlegungen werden die wesentlichen Determinanten des Outsourcings der IV abgeleitet und zu einem theoretischen Bezugsrahmen zusammengefasst. Dieser wird anhand von 34 kleinen und mittleren Unternehmen (KMU) einem empirischen Test unterzogen. Die wesentlichen Ergebnisse der Studie lassen sich wie folgt darstellen: Insgesamt kann der Anteil des Outsourcings der IV in KMU als moderat eingestuft werden. Die Funktionen der IV werden in KMU selektiv, d. h. in unterschiedlichem Maße ausgelagert. Während die Anwendungsentwicklung den höchsten Anteil ausmacht, verbleibt die Planung und das Management weitgehend innerhalb der Unternehmensgrenzen. Die Einschätzung interner Leistungs- und Wissensdefizite gegenüber externen Dienstleistern bildet die dominierende Determinante zur Erklärung des unterschiedlichen Grades der Auslagerung von Funktionen der Informationsverarbeitung. Demgegenüber scheinen Rationalitätskalküle wie die Berücksichtigung von Transaktionskosten und die Einschätzung der strategischen Bedeutung der IV in den Hintergrund zu rücken.
title: Familienorientierung in der Frühförderung aus der Sicht der Mütter
Creators: name: Zuckriegl, Birgit
Year: 2010

description: Frühförderung ist eine Maßnahme zur Förderung von Kindern mit einer Behinderung bzw. Entwicklungsverzögerung bis zum dritten Lebensjahr. Sowohl die Erfahrungen im Rahmen der mobilen Frühförderung als auch aktuelle Analysen (Weiß 2002, Kühl 2002) über die langfristige Wirksamkeit von Fördermaßnahmen weisen auf die Wichtigkeit der Beachtung des familiären Umfeldes hin. Mit dem Prinzip der Familienorientierung innerhalb der Frühförderung erfolgte eine fachliche Perspektivenerweiterung auf die Entwicklungsbedingungen des Kindes, womit auch die Begleitung und Unterstützung der Eltern gemeint ist. In der vorliegenden Diplomarbeit wird der Frage nachgegangen, wie die Familienorientierung innerhalb der Frühförderung von Müttern mit einem Kind mit Behinderung in ihrem Alltagsleben wahrgenommen wird. Im theoretischen Teil werden die vielfältigen Aufgabengebiete von Frühförderung und die verschiedenen Modelle der Zusammenarbeit mit den Eltern vorgestellt. Einen Schwerpunkt bildet die kritische Auseinandersetzung mit dem Prinzip der Familienorientierung im Hinblick auf seine theoretische Fundierung. Die Auswirkungen der Geburt eines Kindes mit Behinderung auf die psychische und soziale Situation der Mütter werden anhand der Bewältigungsmodelle von Jonas und Schuchardt dargestellt. In diesem Zusammenhang wird auch auf die gesellschaftlich-kulturelle Rollenaufteilung eingegangen, die besonders nach der Geburt eines Kindes die soziale Situation der Frauen prägen. Ferner wird auf Besonderheiten des Alltagslebens eingegangen, die sich aufgrund der Behinderung eines Kindes ergeben. Zur Beantwortung der Forschungsfrage wurden im Rahmen einer qualitativen Untersuchung Interviews mit Müttern durchgeführt, deren Kinder am Ende des Frühförderprozesses waren bzw. diesen vor kurzem abgeschlossen hatten. Die Ergebnisse zeigen, dass ein wesentlicher Aspekt der Frühförderung die Begleitung der Mütter im Prozess der Auseinandersetzung mit der Behinderung ihres Kindes ist. Die Informationen über die Behinderung des Kindes, seine Entwicklung sowie die Besonderheiten des jeweiligen Kindes führen bei den Müttern zu einer veränderten Wahrnehmung ihres Kindes und können sich förderlich auf die Mutter-Kind-Beziehung auswirken. Im Hinblick auf den Einbezug anderer Familienmitglieder muss im Rahmen dieser Untersuchung festgestellt werden, dass sich die Angebote der Frühförderung hauptsächlich auf den Einbezug von Geschwisterkindern während einer Fördereinheit beschränken. Angebote der Frühförderinnen an die Gruppe der betreuten Mütter bzw. Familien wie bspw. gemeinsame Spielnachmittage gab es kaum, wobei solche Treffen in ungezwungenem Rahmen von den Müttern gewünscht wurden. Im Hinblick auf die soziale Situation der Mütter kann bezüglich der gewünschten Aufnahme einer Erwerbstätigkeit festgestellt werden, dass bei fast allen Interviewpartnerinnen die Integrationsgespräche bezüglich des Eintritts des Kindes mit Behinderung in einen Kindergarten von der jeweiligen Frühförderin unterstützend begleitet wurden.
Modeling Ziegler-Natta Catalyzed Lldpe With Fov Technique
Creators: name: Alves, Bruno Manuel Ribeiro
Publisher: name: Zenodo
Year: 2017
Subjects: LLDPE; Standard FOV fluid in 1D; FOV Technique; Ziegler-Natta Catalysts; Viscoelasticity; Algorithm.

description: The present work is based on the capacity of modeling experimental data of LLDPE with Ziegler – Natta catalysts with standard FOV fluid in 1D. The purpose of the work is to check about the behavior of LLDPE under flow (were performed static experiments and SAOS experiments). It is seen good adjustments results for G(t), J(t) and dynamic oscillatory experiments. Also, results obey to thermodynamic restrictions imposed by standard FOV fluid in 1D. Throughout this work is possible to compare with a previous work in this area and observe that the capacity of modeling metallocene catalyzed Polyethylene can be extrapolated to LLDPE Ziegler-Natta catalyzed and thus have a model that can be applied to 1 more catalyst. It is expected that this model with 3 parameters can be applied on further investigations with advantages to differential viscoelastic models and integral viscoelastic models.
title: Valuing Follow-up Programs In Head and Neck Cancer
Creators: name: Meregaglia, M
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2018

description: This thesis deals with the topic of head and neck cancer (HNC) follow-up from a health economics perspective. Despite recent advances in treating primary HNC, the long-term prognosis of these patients is still poor due to a high risk of cancer recurrence. Until now, there is no agreement about the best way of monitoring patients after the end of therapies. Moreover, patients’ preferences for alternative surveillance schemes are unknown. A multicentre randomized controlled trial comparing two follow-up strategies of different intensity is currently ongoing in Italy. This thesis aims at filling some of the literature “gaps” around HNC surveillance, using Italy as a case study. The first chapter introduces the topic. The second chapter is a systematic literature review and critical appraisal of economic evaluation studies of post-treatment follow-up programs in any cancer type. The third chapter is a systematic literature review and quality appraisal of studies reporting original health state utility values in HNC, with a focus on articles addressing the post-treatment phase. The fourth chapter maps the EuroQol 5-Dimension 5-Level (EQ-5D-5L) utility values from two cancer-specific measures developed by the European Organization for Research and Treatment of Cancer (EORTC) by using a variety of regression techniques (linear, Tobit, mixture models) and several EQ-5D-5L country tariff sets; the developed functions are useful to inform future economic evaluations in HNC. The fifth chapter presents an exploratory model-based economic evaluation of the two follow-up strategies under investigation in the trial, where an intensive program of radiological assessments is compared to a symptom-driven surveillance; the cost analysis is conducted from a regional healthcare system perspective in Italy. Lastly, the sixth chapter presents a discrete choice experiment using best-worst scaling to elicit patients’ preferences during follow-up at the National Cancer Institute (Milan, Italy).
Co-Innovation in a Service Oriented Strategic Network
Creators: name: Arndt, J.-M.
name: Dibbern, Jens
Publisher: name: IEEE
Year: 2006
Subjects: 000 Computer science, knowledge & systems
650 Management & public relations
330 Economics
300 Social sciences, sociology & anthropology
600 Technology

description: This paper is based on the view that the adoption of service oriented architectures (SOA) by large information system (IS) vendors might push software development towards an industrialized mode of operation. The emergence of such a software ecosystem is analyzed through an innovation perspective. The special nature of software as an intellectual technology, thus being an intangible product as opposed to physical products, is given special emphasis. Since digital products are expensive to produce, but cheap to reproduce, it is argued on the basis of a resource-based view that this ecosystem should not solely be built on the trading of software, but also on the exchange of business knowledge