cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IgY Technology: Extraction of Chicken Antibodies from Egg Yolk by Polyethylene Glycol (PEG) Precipitation
Creators: name: Pauly, Diana
name: Chacana, Pablo A.
name: Calzado, Esteban G.
name: Brembs, Björn
name: Schade, Rüdiger
Publisher: name: Robert Koch-Institut
Year: 2011
Subjects: subject: Animals
subject: Female
subject: Chick Embryo
subject: Chickens
subject: Antibodies/chemistry
subject: Antibodies/immunology
subject: Antibodies/isolation & purification
subject: Egg Yolk/chemistry
subject: Egg Yolk/immunology
subject: Immunoglobulins/chemistry
subject: Immunoglobulins/immunology
subject: Immunoglobulins/isolation & purification
subject: Immunoprecipitation/methods
subject: Polyethylene Glycols/chemistry
subject: 610 Medizin

description: Hens can be immunized by means of i.m. vaccination (Musculus pectoralis, left and right, injection volume 0.5-1.0 ml) or by means of Gene-Gun plasmid-immunization. Dependent on the immunogenicity of the antigen, high antibody-titres (up to 1:100,000 - 1:1,000,000) can be achieved after only one or 3 - 4 boost immunizations. Normally, a hen lays eggs continuously for about 72 weeks, thereafter the laying capacity decreases. This protocol describes the extraction of total IgY from egg yolk by means of a precipitation procedure (PEG. Polson et al. 1980). The method involves two important steps. The first one is the removal of lipids and the second is the precipitation of total IgY from the supernatant of step one. After dialysis against a buffer (normally PBS) the IgY-extract can be stored at -20°C for more than a year. The purity of the extract is around 80 %, the total IgY per egg varies from 40-80 mg, dependent on the age of the laying hen. The total IgY content increases with the age of the hen from around 40 mg/egg up to 80 mg/egg (concerning PEG precipitation). The laying capacity of a hen per year is around 325 eggs. That means a total potential harvest of 20 g total IgY/year based on a mean IgY content of 60 mg total IgY/egg (see Table 1).
Development of Nanoparticles with High Drug Loading Capacity and Stability
Creators: name: Taha, Maie Shaaban
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Oncology and carcinogenesis not elsewhere classified
Chemotherapy
Nanomaterials
Nanomedicine

description: Many anti-cancer drugs are poorly water-soluble and show undesirable pharmacokinetics and low bioavailability. Nanoparticles (NP) are used as delivery vehicles to improve bioavailability and biodistribution of such drugs. For clinical translation of an NP product, it is critical that the NP carry a large amount of drug and maintain good stability during circulation. A typical drug loading capacity of current NP formulations is less than 20% of the total mass, which is concerning from the standpoint of safety and administration convenience. Current NP formulations are also limited in retaining a drug during circulation and release the drug prematurely before they reach target tissues. These challenges are responsible at least partly for recent failure of leading NP products in clinical trials. Given these challenges, I have focused on developing a stable NP formulation with high drug loading capacity, drug-rich nanocores stabilized by interfacial assemblies of iron-tannic acid (pTA) and albumin. Tannic acid is a polyphenol of natural origin and can form coordination complexes with Fe3+ ions that stabilize the interface between drug rich core droplets and aqueous solution. The underlying hypotheses are that (i) NP core formed solely of drug will offer a high drug loading capacity and (ii) the strong interaction of TA with drug molecules will maintain the nanocore stability and avoid premature drug release. Carfilzomib (CFZ), an epoxyketone peptide and a second-generation proteasome inhibitor, the use of which is limited to multiple myeloma due to the low stability, was chosen as a model drug to encapsulate in the new NP formulation. The NP surface was further functionalized with albumin, quinic acid derivative and plasmid DNA based on their affinity for TA complex. With an additional albumin coating, CFZ nanocore (CFZ-pTA-alb) showed sustained drug release and metabolic stability. In murine syngeneic model of B16F10 melanoma, systemically administered CFZ-pTA-alb showed enhanced biodistribution and anti-tumor effect than commercial cyclodextrin-based CFZ (CFZ-CD). With localized intratumoral administration, CFZ-pTA-alb also outperformed CFZ-CD in antitumor efficacy, potentially by prolonged drug retention, reduced damage to tumor-infiltrating lymphocytes, and enhanced delivery of tumor antigens to DCs.
sj-DOCX-1-wmr-10.1177_0734242X211033712 – Supplemental material for An enhanced composting process with bioaugmentation: Mathematical modelling and process optimization
Creators: name: Sokač, Tea
name: Šalić, Anita
name: Kučić Grgić, Dajana
name: Šabić Runjavec, Monika
name: Vidaković, Marijana
name: Jurinjak Tušek, Ana
name: Horvat, Đuro
name: Juras Krnjak, Jasmina
name: Vuković Domanovac, Marija
name: Zelić, Bruno
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-DOCX-1-wmr-10.1177_0734242X211033712 for An enhanced composting process with bioaugmentation: Mathematical modelling and process optimization by Tea Sokač, Anita Šalić, Dajana Kučić Grgić, Monika Šabić Runjavec, Marijana Vidaković, Ana Jurinjak Tušek, Đuro Horvat, Jasmina Juras Krnjak, Marija Vuković Domanovac and Bruno Zelić in Waste Management & Research
Multi-UAV Coverage Path Planning for Reconstruction of 3D Structures
Creators: name: Kannan, Shyam Sundar
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Intelligent robotics
Control engineering, mechatronics and robotics not elsewhere classified

description: Path planning is the generation of paths for the robots to navigate based on some constraints. Coverage path planning is where the robots needs to cover an entire work space for various applications like sensing, inspection and so on. Though there are numerous works on 2D coverage and also coverage using a single robot, the works on 3D coverage and multi-agents are very limited. This thesis makes several contributions to multi-agent path planning for 3D structures.
Motivated by the inspection of 3D structures, especially airplanes, we present a 3D coverage path planning algorithm for a multi-UAV system. We propose a unified method, where the viewpoints selection and path generation are done simultaneously for multiple UAVs. The approach is scalable in terms of number of UAVs and is also robust to models with variations in geometry. The proposed method also distributes the task uniformly amongst the multiple UAVs involved and hence making the best use of the robotics team. The uniform task distribution is an integral part of the path planner. Various performance measures of the paths generated in terms of coverage, path length and time also has been presented.
Evaluating frequency, diagnostic quality, and cost of lyme borreliosis testing in Germany: a retrospective model analysis.
Creators: name: Müller, I.
name: Freitag, M. H.
name: Poggensee, Gabriele
name: Scharnetzky, E.
name: Straube, E.
name: Schoerner, Ch.
name: Hlobil, H.
name: Hagedorn, Hans-Jochen
name: Stanek, G.
name: Schubert-Unkmeir, A.
name: Norris, D. E.
name: Gensichen, J.
name: Hunfeld, K.-P.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2011
Subjects: subject: Humans
subject: Germany/epidemiology
subject: Prevalence
subject: Incidence
subject: Sensitivity and Specificity
subject: Retrospective Studies
subject: Reproducibility of Results
subject: Clinical Laboratory Techniques/standards
subject: Borrelia/immunology
subject: Clinical Laboratory Techniques/economics
subject: Health Care Costs
subject: Insurance Health/economics
subject: Lyme Disease/diagnosis
subject: Lyme Disease/economics
subject: Lyme Disease/epidemiology
subject: Models Statistical
subject: Outpatients
subject: Reagent Kits Diagnostic/standards
subject: 610 Medizin

description: Background: Data on the economic impact of Lyme borreliosis (LB) on European health care systems is scarce. This project focused on the epidemiology and costs for laboratory testing in LB patients in Germany. Materials and Methods: We performed a sentinel analysis of epidemiological and medicoeconomic data for 2007 and 2008. Data was provided by a German statutory health insurance (DAK) company covering approx. 6.04 million members. In addition, the quality of diagnostic testing for LB in Germany was studied. Results: In 2007 and 2008, the incident diagnosis LB was coded on average for 15,742 out of 6.04 million insured members (0.26%). 20,986 EIAs and 12,558 immunoblots were ordered annually for these patients. For all insured members in the outpatient sector, a total of 174,820 EIAs and 52,280 immunoblots were reimbursed annually to health care providers (cost: 2,600,850€). For Germany, the overall expected cost is estimated at 51,215,105€. However, proficiency testing data questioned test quality and standardization of diagnostic assays used. Conclusion: Findings from this study suggest ongoing issues related to care for LB and may help to improve future LB disease management.
Additional file 1 of Triglyceride-glucose index: a novel evaluation tool for all-cause mortality in critically ill hemorrhagic stroke patients-a retrospective analysis of the MIMIC-IV database
Creators: name: Huang, Yongwei
name: Li, Zongping
name: Yin, Xiaoshuang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Prinzipien und Aspekte der Seuchenalarmplanung am Beispiel der Influenzapandemieplanung
Creators: name: Haas, Walter
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2005
Subjects: subject: Influenza
subject: Pandemie
subject: H5N1
subject: Aviäre Influenza
subject: General Preparedness
subject: Pandemics
subject: Avian influenza
subject: General preparedness
subject: 610 Medizin

description: In den letzten Jahren ist zunehmend deutlich geworden, dass ungeachtet der Fortschritte der Medizin Infektionskrankheiten nicht an Bedeutung verloren haben, sondern das Risiko weltweiter Epidemien gestiegen ist. Aufgrund ihrer hohen Infektiosität und der raschen Ausbreitung von Mensch zu Mensch stellt die Entstehung neuer Influenzaviren mit pandemischem Potenzial eine besondere Bedrohung dar. Ein Pandemievirus trifft auf eine immunologisch „naive“ Bevölkerung, in der es sich wie ein Lauffeuer ausbreiten kann. Drei Pandemien allein im vergangenen Jahrhundert belegen, dass die Entstehung einer Influenzapandemie kein hypothetisches Risiko darstellt. Aktuell muss befürchtet werden, dass durch die zunehmende Anpassung der endemisch in Asien zirkulierenden aviären Influenzaviren an den Menschen ein neues Pandemievirus entstehen kann. Mit der Veröffentlichung des Nationalen Influenzapandemieplans für Deutschland zu Beginn dieses Jahres hat die diesbezügliche Planung und Vorbereitung ein wesentliches Etappenziel erreicht. Die Umsetzung der erforderlichen Maßnahmen muss nun rasch vorangetrieben werden, wobei diese weit über den Bereich des Gesundheitssystems hinausgehen. Die langfristige Zielsetzung ist eine bessere Vorbereitung auf Gesundheitsgefahren, insbesondere durch die Entstehung neuer Seuchen unter den Bedingungen einer zunehmenden globalen Vernetzung.
description: Despite significant medical progress, recent events have shown that infectious diseases have not lost significance. Indeed, the threat of worldwide epidemics has increased. Due to their high infectious ness and rapid person-to-person transmissibility, the emergence of new influenza viruses with pandemic potential poses an especially alarming situation in this regard. The world population would be “immunologically naïve” to a new pandemic virus, permitting explosive spread of the disease. During the last century, three influenza pandemics have demonstrated that this is not merely a hypothetical risk. Currently it is feared that the possible human adaptation of avian influenza viruses that have recently become endemic in birds in Southeast Asia could result in a new pandemic strain. With the publication of the German Influenza Pandemic Preparedness Plan, preparation for this potential threat has reached an important stage in Germany. The implementation of the plan, which includes measures that go beyond the scope of public health, must now proceed swiftly. The long-term goal of pandemic preparedness planning is to be better equipped to deal with potential health threats in general, in particular those ensuing from the emergence of new infectious diseases under conditions of a growing global network.
Modelling The Evolution Of The Tv Drama Production Sector In The Uk
Creators: name: Paterson, Richard
Publisher: name: Zenodo
Year: 2018
Subjects: TV Industry
TV Drama
Television production

description: This exploratory paper considers the evolution of drama production companies in the UK against the backdrop of regulatory interventions (Paterson, 2017a). In so doing, it poses the question of what was it that made a successful drama production company as the context of tv production changed. A set of firm types of current drama production companies is established, the density of companies occupying this niche mapped, and the growing heterogeneity of firm types over time identified. Firms within these types are examined applying the fitness landscape methodology, developed for the analysis of organisations from complexity theory (Kauffman, 1993). This approach offers a dynamic conception of an industrial sector in continuous change responding to the technological, market and the endogenous factors with which firms engage. The adaptive walks of a set of companies within each firm type are plotted by examining a company’s reputation, their access to talent and their ability to secure commissions and raise finance for development and production.  What becomes possible for a company at particular junctures – the adjacent possible - is variable, but as will be demonstrated routes to growth have tended to become normative once any innovation in organizational form is successful. The implications of this approach are broached in relation to further possible policy interventions and broader technological changes.
Additional file 1 of Effectiveness and safety of the combination of sodium–glucose transport protein 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies
Creators: name: Ahmad, Aftab
name: Sabbour, Hani
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified

description: Additional file 1: Table S1. Search strategy for the systematic literature review. Table S2. List of studies excluded at the full-text screening stage with reasons for exclusion. Table S3. List of studies excluded from the meta-analysis and reasons for exclusion.
Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions.
Creators: name: Wevers, Diana
name: Metzger, Sonja
name: Babweteera, Fred
name: Bieberbach, Marc
name: Boesch, Christophe
name: Cameron, Kenneth
name: Couacy-Hymann, Emmanuel
name: Cranfield, Mike
name: Gray, Maryke
name: Harris, Laurie A.
name: Head, Josephine
name: Jeffery, Kathryn
name: Knauf, Sascha
name: Lankester, Felix
name: Leendertz, Siv Aina J.
name: Lonsdorf, Elizabeth
name: Mugisha, Lawrence
name: Nitsche, Andreas
name: Reed, Patricia
name: Robbins, Martha
name: Travis, Dominic A.
name: Zommers, Zinta
name: Leendertz, Fabian
name: Ehlers, Bernhard
Publisher: name: Robert Koch-Institut
Year: 2011
Subjects: subject: Humans
subject: Phylogeny
subject: Genotype
subject: Polymerase Chain Reaction
subject: Animals
subject: Viral Proteins/genetics
subject: Genetic Variation
subject: Zoonoses/transmission
subject: Primate Diseases/virology
subject: DNA Primers/genetics
subject: Adenoviridae/isolation & purification
subject: Adenoviridae Infections/transmission
subject: Adenoviridae Infections/veterinary
subject: DNA-Directed DNA Polymerase/genetics
subject: Primates/virology
subject: Zoonoses/virology
subject: Sequence Analysis DNA
subject: DNA Viral/genetics
subject: Adenoviridae/classification
subject: Adenoviridae/genetics
subject: Adenoviridae Infections/virology
subject: DNA Viral/chemistry
subject: Animals Wild/virology
subject: Capsid Proteins/genetics
subject: Disease Transmission Infectious
subject: Primate
subject: Diseases/transmission
subject: 610 Medizin

description: Adenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly conserved adenovirus DNA polymerase gene. A plethora of novel AdV sequences were identified, representing at least 45 distinct AdVs. From the AdV-positive individuals, 29 nearly complete hexon genes were amplified and, based on phylogenetic analysis, tentatively allocated to all known human AdV species (Human adenovirus A to Human adenovirus G [HAdV-A to -G]) as well as to the only simian AdV species (Simian adenovirus A [SAdV-A]). Interestingly, five of the AdVs detected in great apes grouped into the HAdV-A, HAdV-D, HAdV-F, or SAdV-A clade. Furthermore, we report the first detection of AdVs in New World monkeys, clustering at the base of the primate AdV evolutionary tree. Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events.
An Adversarial Approach to Spliced Forgery Detection and Localization in Satellite Imagery
Creators: name: Bartusiak, Emily R
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Image processing
Artificial intelligence not elsewhere classified
Knowledge representation and reasoning

description: The widespread availability of image editing tools and improvements in image processing techniques make image manipulation feasible for the general population. Oftentimes, easy-to-use yet sophisticated image editing tools produce results that contain modifications imperceptible to the human observer. Distribution of forged images can have drastic ramifications, especially when coupled with the speed and vastness of the Internet. Therefore, verifying image integrity poses an immense and important challenge to the digital forensic community. Satellite images specifically can be modified in a number of ways, such as inserting objects into an image to hide existing scenes and structures. In this thesis, we describe the use of a Conditional Generative Adversarial Network (cGAN) to identify the presence of such spliced forgeries within satellite images. Additionally, we identify their locations and shapes. Trained on pristine and falsified images, our method achieves high success on these detection and localization objectives.
De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics
Creators: name: Kalb, Suzanne R.
name: Baudys, Jakub
name: Rees, Jon C.
name: Smith, Theresa J.
name: Smith, Leonard A.
name: Helma, Charles H.
name: Hill, Karen
name: Kull, Skadi
name: Kirchner, Sebastian
name: Dorner, Martin
name: Dorner, Brigitte
name: Pirkle, James L.
name: Barr, John R.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2012
Subjects: subject: Botulinum neurotoxin
subject: Botulism
subject: Mass spectrometry
subject: Proteomics
subject: 610 Medizin

description: Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. There are seven known serotypes of BoNT, A–G, defined by their response to antisera. Many serotypes are distinguished into differing subtypes based on amino acid sequence, and many subtypes are further differentiated into toxin variants. Previous work in our laboratory described the use of a proteomics approach to distinguish subtype BoNT/A1 from BoNT/A2 where BoNT identities were confirmed after searching data against a database containing protein sequences of all known BoNT/A subtypes. We now describe here a similar approach to differentiate subtypes BoNT/B1, /B2, /B3, /B4, and /B5. Additionally, to identify new subtypes or hitherto unpublished amino acid substitutions, we created an amino acid substitution database covering every possible amino acid change. We used this database to differentiate multiple toxin variants within subtypes of BoNT/B1 and B2. More importantly, with our amino acid substitution database, we were able to identify a novel BoNT/B subtype, designated here as BoNT/B7. These techniques allow for subtype and strain level identification of both known and unknown BoNT/B rapidly with no DNA required.
Additional file 2 of Effectiveness and safety of the combination of sodium–glucose transport protein 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies
Creators: name: Ahmad, Aftab
name: Sabbour, Hani
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified

description: Additional file 2. Assessment of study quality and data extraction.
sj-pdf-1-jnp-10.1177_23993693211028593 – Supplemental material for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases
Creators: name: Bersanelli, Melissa
name: Buti, Sebastiano
name: Gnetti, Letizia
name: Varotti, Elena
name: Carbognani, Paolo
name: Rusca, Michele
name: Leonardi, Francesco
name: Campanini, Nicoletta
name: Ziglioli, Francesco
name: Dadomo, Clara Indira
name: Pilato, Francesco Paolo
name: Ventura, Luigi
name: Braggio, Cesare
name: Bocchialini, Giovanni
name: Cortellini, Alessio
name: Brunelli, Matteo
name: Rapacchi, Elena
name: Camisa, Roberta
name: Caruso, Giuseppe
name: Silini, Enrico Maria
name: Maestroni, Umberto
name: Ampollini, Luca
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-jnp-10.1177_23993693211028593 for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases by Melissa Bersanelli, Sebastiano Buti, Letizia Gnetti, Elena Varotti, Paolo Carbognani, Michele Rusca, Francesco Leonardi, Nicoletta Campanini, Francesco Ziglioli, Clara Indira Dadomo, Francesco Paolo Pilato, Luigi Ventura, Cesare Braggio, Giovanni Bocchialini, Alessio Cortellini, Matteo Brunelli, Elena Rapacchi, Roberta Camisa, Giuseppe Caruso, Enrico Maria Silini, Umberto Maestroni and Luca Ampollini in Journal of Onco-Nephrology
Liquid Nitrate Fertilizer Production with Various Atmospheric Pressure Discharges
Creators: name: Shen, Zhenyu
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Plasma physics; fusion plasmas; electrical discharges

description: Plasmas can be used to increase the probability of maturity of seeds and disinfect them. The water applied on plants can also be treated with plasma to reduce bacteria. Discharges normally used to treat water including dielectric barrier discharges, gliding arcs, DC, AC, or pulsed coronas, and various direct discharges in liquid. After treatments, reactive oxygen (ozone) and nitrogen species (nitrite and nitrate) will appear in the water solution. Then, by applied this water, the lifecycle of plant could be significantly influenced. Plasma has a great potential to play an important role in the agriculture discipline. The process of synthesizing nitrate fertilizer with water, air, and electric spark has been known for a long time. But due to low nitrate yield and high energy consumption, it was replaced by the Haber-Bosch process in the first half of the 20th century. The Haber-Bosch process, however, has several disadvantages: it requires natural gas as a raw material, fixes nitrogen in the form of ammonia, and generates oxycarbides as byproducts. Thus, the concept of manufacturing nitrogen fertilizer with only water, air and electricity is still appealing.
In this project, we want to measure the pH value and conductivity of the water treated by various atmospheric pressure discharges including the arc discharge, DC positive corona discharge, DC voltage driven cold plasma torch operating with helium, dielectric barrier discharge (DBD), and radio-frequency (RF) plasma. Also, it is necessary to verify the existence of different important species in the treated water such as peroxide, nitrite, and nitrate ions by measuring their concentrations. Based on current and voltage measurements and wall-plug electrical energy consumption, energy efficiency of nitrate synthesis was determined in these five plasma systems. Optical emission spectroscopy was employed to study the reaction kinetics of both DBD and RF discharge. Our goal is to produce enough nitrate ions, by plasma treatment with minimal energy input (the value should be at least close to the Haber-Bosch process), in water which could be further used as fertilizers.
The FIFA Women’s World Cup in Germany 2011 – A practical example for tailoring an event-specific enhanced infectious disease surveillance system
Creators: name: Takla, Anja
name: Velasco, Edward
name: Benzler, Justus
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2012
Subjects: subject: Humans
subject: Female
subject: Germany/epidemiology
subject: Population Surveillance/methods
subject: World Health
subject: Anniversaries and Special Events
subject: Communicable Disease Control/methods
subject: Communicable Diseases/epidemiology
subject: Soccer
subject: Needs Assessment
subject: 610 Medizin

description: Background: Mass gatherings require a decision from public health authorities on how to monitor infectious diseases during the event. The appropriate level of enhanced surveillance depends on parameters like the scale of the event (duration, spatial distribution, season), participants’ origin, amount of public attention, and baseline disease activity in the host country. For the FIFA Men’s World Cup 2006, Germany implemented enhanced surveillance. As the scale of the FIFA Women’s World Cup (June 26 – July 17, 2011) was estimated to be substantially smaller in size, visitors and duration, it was not feasible to simply adopt the previously implemented measures. Our aim was therefore to develop a strategy to tailor an event-specific enhanced surveillance for this smaller-scale mass gathering. Methods: Based on the enhanced surveillance measures during the Men’s Cup, we conducted a needs assessment with the district health authorities in the 9 host cities in March 2011. Specific measures with a majority consent were implemented. After the event, we surveyed the 9 district and their corresponding 7 state health authorities to evaluate the implemented measures. Results All 9 district health authorities participated in the pre-event needs assessment. The majority of sites consented to moving from weekly to daily (Monday-Friday) notification reporting of routine infectious diseases, receiving regular feedback on those notification reports and summaries of national/international World Cup-relevant epidemiological incidents, e.g. outbreaks in countries of participating teams. In addition, we decided to implement twice-weekly reports of “unusual events” at district and state level. This enhanced system would commence on the first day and continue to one day following the tournament. No World Cup-related infectious disease outbreaks were reported during this time period. Eight of 9 district and 6 of 8 state health authorities participated in the final evaluation. The majority perceived the implemented measures as adequate. Conclusions: Our approach to tailor an event-specific enhanced surveillance concept worked well. Involvement of the participating stakeholders early-on in the planning phase secured ownership of and guaranteed support for the chosen strategy. The enhanced surveillance for this event resulted as a low-level surveillance. However, we included mechanisms for rapid upscaling if the situation would require adaptations.
Additional file 4 of Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
Creators: name: Deng, Yu
name: Jin, Hongyan
name: Ning, Jie
name: Cui, Dong
name: Zhang, Muqiu
name: Yang, Huixia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Table 1. Primer sequences used in RT-qPCR.
ZAMONAVIY KOMPYUTERLAR BO'LIMINI O'QITISH METODIKASI
Creators: name: Rajabova, Moxinur
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqola zamonaviy kompyuterlar bo‘limini o‘qitish metodikasining samaradorligini tahlil qiladi. Maqolada an’anaviy va innovatsion o‘qitish metodlarining o‘zaro ta’siri, kompyuter fanlarini o‘rgatishda yuzaga keladigan asosiy muammolar va ularni yechish uchun takliflar ko‘rib chiqilgan. Asosiy e’tibor zamonaviy metodlar, masalan, loyiha asosida o‘qitish, muammoli yondashuv, flipped learning, STEAM yondashuvi va raqamli platformalarning dars jarayonida qo‘llanilishiga qaratilgan. Shuningdek, o‘qituvchilarning metodik tayyorgarligi, zamonaviy texnologiyalardan foydalanish ko‘nikmalari va o‘quvchilarda mustaqil fikrlash, ijodiy yondashuvni rivojlantirishning ahamiyati ta’kidlanadi. Maqolada shuningdek, o‘quvchilarning texnologik tayyorgarligini zamonaviy talablar asosida shakllantirishga yo‘naltirilgan tavsiyalar berilgan. Ushbu tadqiqot, kompyuter fanlarini o‘qitishda metodik yondashuvlarni yangilash, o‘quvchilarning amaliy ko‘nikmalarini oshirish hamda o‘qituvchilarning professionallik darajasini takomillashtirish zarurligini ko‘rsatadi.
DESIGN AND DEVELOPMENT OF AN INTELLIGENT ONLINE PERSONAL ASSISTANT IN SOCIAL LEARNING MANAGEMENT SYSTEMS
Creators: name: Asanjan, Seyed Mahmood Hosseini
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Software engineering not elsewhere classified
Digital processor architectures
Other information and computing sciences not elsewhere classified
Applied computing not elsewhere classified

description: Over the past decade, universities had a significant improvement in using online learning tools. A standard learning management system provides fundamental functionalities to satisfy the basic needs of its users. The new generation of learning management systems have introduced a novel system that provides social networking features. An unprecedented number of users use the social aspects of such platforms to create their profile, collaborate with other users, and find their desired career path. Nowadays there are many learning systems which provide learning materials, certificates, and course management systems. This allows us to utilize such information to help the students and the instructors in their academic life.
The presented research work's primary goal is to focus on creating an intelligent personal assistant within the social learning systems. The proposed personal assistant has a human-like persona, learns about the users, and recommends useful and meaningful materials for them. The designed system offers a set of features for both institutions and members to achieve their goal within the learning system. It recommends jobs and friends for the users based on their profile. The proposed agent also prioritizes the messages and shows the most important message to the user.
The developed software supports model-controller-view architecture and provides a set of RESTful APIs which allows the institutions to integrate the proposed intelligent agent with their learning system.
The Pathology of Experimental Poxvirus Infection in Common Marmosets (Callithrix jacchus): Further Characterization of a New Primate Model for Orthopoxvirus Infections
Creators: name: Mätz-Rensing, Kerstin
name: Stahl-Hennig, Christiane
name: Kramski, Marit
name: Pauli, Georg
name: Ellerbrok, Heinz
name: Kaup, Franz-Josef
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2011
Subjects: subject: Callithrix jacchus
subject: calpox virus
subject: common marmoset
subject: non-human primate model
subject: 610 Medizin

description: Zoonotic orthopoxvirus (OPV) can induce severe disease in man and the virus has potential for use in bioterrorism. New vaccines and therapeutics against OPV infections must be tested in animal models. The aim of this study was to characterize the clinical course and pathology of a new OPV isolate, calpox virus, which is infectious in marmosets. Infection experiments were performed with 28 common marmosets (Callithrix jacchus) exposed to different challenge doses of calpox virus by the intravenous, oropharyngeal and intranasal (IN) routes. The median marmoset IN infectious dose corresponded to 8.3 × 102 plaque forming units of calpox virus. Infected animals developed reproducible clinical signs and died within 4–15 days post infection. Characteristic pox-like lesions developed in affected organs, particularly in the skin, mucous membranes, lymph nodes, liver and spleen. Calpox virus disease progression and pathological findings in the common marmoset appear to be consistent with lethal OPV infections in man and in other non-human primate (NHP) models. IN inoculation with low virus doses mimics the natural route of the human variola virus infection. Thus, the marmoset model of calpox virus infection can be considered to be relevant to investigation of the mechanisms of OPV pathogenesis and pathology and for the evaluation of new vaccines and antiviral therapies.
Crime Fiction and Black Criminality
Creators: name: Martin, Theodore
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: American literature
subject: History
subject: Americans--Social life and customs
subject: Nineteenth century
subject: Twentieth century
subject: Detective and mystery stories
subject: Critical race theory

description: This essay demonstrates how mid-twentieth-century crime fiction developed in response to midcentury discourses of racial criminality. In the 1950s, the myth of black criminality served to mediate anxieties about the emerging Civil Rights movement and rising rates of black unemployment. In this context, crime novelists found it increasingly difficult to ignore the link between the narration of crime and the criminalization of race. What did it mean to write about crime in the shadow of postwar US racial politics? I argue that this question helped define the distinctive midcentury genre of novels about criminals. While novelists like Patricia Highsmith used the backdrop of racial criminalization to write about the inner lives of white criminals, other writers, including Dorothy B. Hughes, Charles Willeford, and most importantly Richard Wright, focused directly on the narrative dilemmas posed by the black criminal protagonist. Through their literary attempts to uncouple race from crime, these writers show us how the genre of crime fiction became a key cultural form for grappling with the politics of race and crime.
Analysis of influenza B virus NS1 protein trafficking reveals a novel interaction with nuclear speckle domains
Creators: name: Schneider, Jana
name: Dauber, Bianca
name: Melén, Krister
name: Julkunen, Ilkka
name: Wolff, Thorsten
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2008
Subjects: subject: Animals
subject: Cell Line
subject: Humans
subject: Influenza B virus/physiology
subject: Viral Nonstructural Proteins/genetics
subject: Viral Nonstructural Proteins/metabolism
subject: Virus Replication
subject: Cytoplasm/chemistry
subject: Protein Interaction Mapping
subject: Cell Nucleus/chemistry
subject: Nuclear Localization Signals
subject: Protein Interaction Domains and Motifs
subject: Spodoptera
subject: 610 Medizin

description: Many proteins that function in the transcription, maturation, and export of metazoan mRNAs are concentrated in nuclear speckle domains, indicating that the compartment is important for gene expression. Here, we show that the NS1 protein of influenza B virus (B/NS1) accumulates in nuclear speckles and causes rounding and morphological changes of the domains, indicating a disturbance in their normal functions. This property was located within the N-terminal 90 amino acids of the B/NS1 protein and was shown to be independent of any other viral gene product. Within this protein domain, we identified a monopartite importin α binding nuclear localization signal. Reverse-genetic analysis of this motif indicated that nuclear import and speckle association of the B/NS1 protein are required for the full replication capacity of the virus. In the late phase of virus infection, the B/NS1 protein relocated to the cytoplasm, which occurred in a CRM1-independent manner. The interaction of the B/NS1 protein with nuclear speckles may reflect a recruitment function to promote viral-gene expression. To our knowledge, this is the first functional description of a speckle-associated protein that is encoded by a negative-strand RNA virus.
Additional file 3 of Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
Creators: name: Deng, Yu
name: Jin, Hongyan
name: Ning, Jie
name: Cui, Dong
name: Zhang, Muqiu
name: Yang, Huixia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Fig. 3. The percentages of apoptosis (early apoptosis, late apoptosis, and early apoptosis plus late apoptosis) of HTR-8/SVneo cells were measured by flow cytometry after treatment with foxc1-siRNA-516.
Management und Kontrolle lebensbedrohender hochkontagiöser Infektionskrankheiten
Creators: name: Fock, Rüdiger
name: Wirtz, Alfred
name: Peters, M.
name: Finke, E.-J.
name: Koch, U.
name: Scholz, D.
name: Niedrig, Matthias
name: Bußmann, H.
name: Fell, Gerhard
name: Bergmann, H.
Publisher: name: Robert Koch-Institut
Year: 1999
Subjects: subject: Internationale Gesundheitsvorschriften
subject: Reisemedizin
subject: Tropenkrankheiten
subject: Quarantäne
subject: Seuchenhygiene
subject: Virusbedingte hämorrhagische Fieber (Ebola Marburg Lassa Krim-Kongo)
subject: Pest
subject: Emerging diseases
subject: öffentlicher Gesundheitsdienst
subject: Zivilmilitärische Zusammenarbeit
subject: Tropical Diseases
subject: Quarantine
subject: Viral Haemorrhagic Fevers (Ebola-Marburg Viral Diseases Lassa Fever Crimean-Congo Haemorrhagic Fever)
subject: Pneumonic Plague
subject: Control of Epidemics
subject: International Health Regulations
subject: Travelling Medicine
subject: Emerging Diseases
subject: Public Health (Services)
subject: Civilian-Military Co-operation
subject: 610 Medizin

description: Ein Einschleppen lebensbedrohender und zugleich hochkontagiöser Infektionskrankheiten wie Lungenpest oder Ebola-Fieber nach Deutschland erscheint zur Zeit nicht sehr wahrscheinlich, ist aber grundsätzlich nicht auszuschließen. Gerade wegen der Seltenheit des Auftretens einer solchen Erkrankung sind jedoch auch hierzulande Handlungsrichtlinien notwendig, um gegebenenfalls einer Verbreitung entgegenzuwirken. Die Entwicklung konkreter Schutzvorkehrungen und Handlungsalgorithmen sowie das Vorhalten geeigneter Diagnostik- und Behandlungseinrichtungen ist in den einzelnen Regionen Deutschlands sehr unterschiedlich ausgeprägt. Ein bundesweiter Rahmenplan fehlt. Der vorliegende Konzeptentwurf zeigt, wie die Vorsorge mit vertretbarem finanziellen Mehraufwand durch eine gemeinsame überregionale Nutzung der z. T. vorhandenen Infrastruktur und durch eine Vereinbarung bundeseinheitlicher Vorgehensweisen wesentlich verbessert werden kann.
description: At present, the importation into Germany of life-threatening and highly contagious diseases such as pneumonic plague and Ebola is unlikely, but cannot be ruled out. In spite of the extreme rarity of these diseases, guidelines are necessary to prevent the spread of these agents in case of their importation. In Germany, marked regional differences exist with respect to the development of emergency regulations and the availability of specialized centers for diagnostics and therapy. A federal framework is missing. A concept is presented here in which the capacity to respond is substantially augmented with limited additional cost through inter-regional cooperation using existing infrastructure and federally standardized procedures.
Investigation of a New Electrostatic Sampler for Concentrating Biological and Non-Biological Aerosol Particles
Creators: name: Roux, Jean-Maxime
name: Kaspari, Oliver
name: Heinrich, Renate
name: Hanschmann, Nicole
name: Grunow, Roland
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2013
Subjects: subject: 610 Medizin

description: The detection of airborne pathogens is becoming a subject of great concern in modern day society. Recent studies have shown that electrostatic samplers are suitable for collecting microorganisms as well as preserving their viability. In most of these studies, flow rates were lower than 12.5 L/min or required a concentration stage to increase the flow rate to 100 L/min. In the present study, a single stage electrostatic sampler was developed for an efficient collection of microorganisms at 100 L/min. The design is based on the positive DC corona between coaxial cylinders to continuously create charged particles as they pass through the sampler. The physical collection efficiency of the device was investigated by sampling the ambient air particles. The efficiency in collecting live biological samples was determined by sampling live bacterial spores with the collector situated inside an aerosol chamber. It is shown that particles of 0.3–0.35 μm are captured with an efficiency of about 86%, whereas cultivable spores of Bacillus thuringiensis are collected with an efficiency of about 94%. Results are compared with an analytical predictive model. The experimental results are similar to the efficiencies previously reported in the literature; however, the current sampler design features a higher flow rate which enables the device to be used as an alarm trigger in a shorter period of time.
A Pragmatic Analysis of WISH Imperatives
Creators: name: Nomura, Ryo
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Linguistics not elsewhere classified
Discourse and pragmatics
Japanese language
English language
Natural language processing
Comparative language studies
Philosophy of language

description: A word or a linguistic construction can mean various things depending on the context. The imperative is a representative example of such a construction and can express a variety of illocutionary forces such as COMMAND, REQUEST, ADVICE, and more (Quirk et al., 1985, Huddleston et al., 2002). However, although there are many studies that comprehensively deal with the imperative or individual illocutionary forces of it (e.g. Lakoff, 1966, Ljung, 1975, Davies, 1986, Wilson & Sperber 1988, Han, 2000, Takahashi, 2012, Jary & Kissine, 2014), there is no such study that shows a possible overall process of how we would interpret an imperative to reach a certain illocutionary force when it is uttered. Without such a shared process, we cannot explain why we can communicate using imperatives without misunderstandings. Thus, this process needs to be investigated. Another problem regarding imperatives is the treatment of non-directive uses of imperatives such as “Have a good day”. The illocutionary force of this imperative would be called GOOD WISH and regarded as a conventional use of imperatives (Davies, 1986). However, it has not been clearly explained why we would choose the imperative construction to express wishes. If this kind of wishes expressed in the form of the imperative are actually a use of imperative, then there should be some reason and motivation for it. The main purposes of this study are to provide (1) a schema of how one would typically reach the interpretation of WISH when hearing an imperative and (2) an account of such use of imperatives as WISH. In this study, examples of imperatives in two non-cognate languages are used for the analysis in the hope to substantiate the credibility of the schema and the account: Japanese and English. Based on the analyses on the imperative and individual illocutionary forces that have been presented in the literature combined with my own analysis, a schema is proposed that illustrates how one would typically reach PRIVATE WISH, the state of affairs of which is deemed to be desirable mainly for the speaker, and GOOD WISH, the state of affairs of which is deemed to be desirable mainly for the addressee. Then, an account for the use of PRIVATE WISH and GOOD WISH is provided. Specifically, the use of imperatives as WISH is an analogous use of prototypical imperatives; people would use the imperative construction to express their strong desirability, and to build and maintain a good relationship with others.
Additional file 1 of Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
Creators: name: Deng, Yu
name: Jin, Hongyan
name: Ning, Jie
name: Cui, Dong
name: Zhang, Muqiu
name: Yang, Huixia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Fig. 1. Plasma galectin-3 levels of cord blood in gestational diabetes mellitus (GDM) and healthy pregnant women (HP) groups.