cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Isoperimetry, scalar curvature, and mass in asymptotically flat Riemannian $3$-manifolds
Creators: name: Chodosh, Otis
name: Eichmair, Michael
name: Shi, Yuguang
name: Yu, Haobin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 53C20, Secondary 83C99

description: Let $(M, g)$ be an asymptotically flat Riemannian $3$-manifold with non-negative scalar curvature and positive mass. We show that each leaf of the canonical foliation through stable constant mean curvature surfaces of the end of $(M, g)$ is uniquely isoperimetric for the volume it encloses.
description: All comments welcome
Raman studies on nanocomposite silicon carbonitride thin film deposited by RF magnetron sputtering at different substrate temperatures
Creators: name: Bhattacharyya, A. S.
name: Mishra, S. K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Raman studies of nanocomposite SiCN thin film by sputtering showed that with an increase of substrate temperature from room temperature to 500oC, a transition from mostly sp2 graphitic phase to sp3 carbon took place which was observed from the variation of ID/IG ratio and the peak shifts. This process resulted in the growth of C3N4 and Si3N4 crystallites in the amorphous matrix which led to an increase in hardness and modulus obtained through nanoindentation. However, at a further higher temperature of 600oC, again an increase of sp2 C concentration in the film was observed and the H and E values showed a decrease due to increased growth of graphitic carbon phase. The whole process got reflected in a modified four stage Ferrari Robertson model of Raman spectroscopy.
description: 17 Pages, 5 figures
Molecular dynamics simulation of bioactive compounds of Withania somnifera leaf extract as DNA gyrase inhibitor
Creators: name: Begum, Sartaz
name: Shadrack, Daniel M.
name: Joseph, Ferister M.
name: Ndensendo, Valence M. K.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Plant Biology

description: Medicinal plants have served humans as medicine for centuries. Withania somnifera (L.) (Ashwagandha) leaf extract is traditionally used in managing and treating bacterial infections. A combination of experimental and computational methods was used to investigate the related antibacterial mechanism. Leaf extract showed strong antibacterial activity against S. aureus. Moreover, molecular docking established that withanolide C, a compound obtained from methanolic leaf extract binded strongly to DNA gyrase enzyme. Molecular dynamics simulation and molecular mechanics Poisson-Boltzmann surface area binding free energy suggested withanolide C to be stable at the active site of DNA gyrase B. The compound binded in a different fashion as compared to chlorobiocin a known DNA gyrase inhibitor. Present finding suggests that the antibacterial activity of W. somnifera is due to inhibition of DNA gyrase by withanolide C. This finding serves as the basis for development of novel antimicrobial agents. Communicated by Ramaswamy H. Sarma
The Impacts of Trade Liberalization on Agricultural Export Performance in Ethiopia
Creators: name: Abera, Genet
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2008

description: Developing countries have experienced extensive and rapid trade liberalization in recent years which undertaken both in the context of multilateral trade negotiations and as part of the conditionality linked to the structural adjustment and stabilization programs agreed with the International Monetary Fund (IMF) and the World Bank (WB). The impact of Trade Liberalization/Economic reforms on export performance is controversial even if it is widely adopted in developing countries. The aim of this paper is to analyze the impact of economic reform policies on the agricultural export performance of Ethiopia; especially, diversification, competitiveness and openness for the period 1974 to 2004. The main question addressed here is whether the reforms made has a positive impact on the export performance of the country; and to analyze the relative importance of domestic supply related factors such as diversification, competitiveness and openness as compared with external demand conditions in determining agricultural export performance of the country. The performance of the sector is analyzed using these four indicator time series variables to capture the effects of both international market potential and domestic supply side policy reforms. The data are analyzed using Ordinary Least Squares (OLS) and Error Correction Model (ECM) frameworks to examine the impact of trade policy on the agricultural export expansion of the country both in the short run and in the long run. The main findings of the analysis are agricultural export performance is more sensitive to the domestic supply side policy reforms like diversification and openness. Among them diversification is an important factor that explains export performance both in the short run and in the long run, indicating that the country should continue to diversify her exports.
Fabrication of composite and nanocomposite biosensors for nitrate analysis
Creators: name: Sohail, Manzar
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
In-silico screening and identification of potential inhibitors against 2Cys peroxiredoxin of Candidatus Liberibacter asiaticus
Creators: name: Gupta, Deena Nath
name: Dalal, Vikram
name: Savita, Brajesh Kumar
name: Dhankhar, Poonam
name: Ghosh, Dilip Kumar
name: Kumar, Pravindra
name: Sharma, Ashwani Kumar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Huanglongbing (HLB) is a worldwide citrus plant disease-related to non-culturable and fastidious α-proteobacteria Candidatus Liberibacter asiaticus (CLas). In CLas, Peroxiredoxin (Prx) plays a major role in the reduction of the level of reactive species such as reactive oxygen species (ROS), free radicals and peroxides, etc. Here, we have used structure-based drug designing approach was used to screen and identify the potent molecules against 2Cys Prx. The virtual screening of fragments library was performed against the three-dimensional validated model of Prx. To evaluate the binding affinity, the top four molecules (N-Boc-2-amino isobutyric acid (B2AI), BOC-L-Valine (BLV), 1-(boc-amino) cyclobutane carboxylic acid (1BAC), and N-Benzoyl-DL-alanine (BDLA)) were docked at the active site of Prx. The molecular docking results revealed that all the identified molecules had a higher binding affinity than Tert butyl hydroperoxide (TBHP), a substrate of Prx. Molecular dynamics analysis such as RMSD, Rg, SASA, hydrogen bonds, and PCA results indicated that Prx-inhibitor(s) complexes had lesser fluctuations and were more stable and compact than Prx-TBHP complex. MMPBSA results confirmed that the identified compounds could bind at the active site of Prx to form a lower energy Prx-inhibitor(s) complex than Prx-TBHP complex. The identified potent molecules may pave the path for the development of antimicrobial agents against CLA. Communicated by Ramaswamy H. Sarma
The Challenges Faced by Faculty in Managing Teaching and Research Responsibilities with special reference to Coimbatore City: A Study overview
Creators: name: Dr.D.Samundeeswari, Mr.R.Abinesh, Mr.T.K.Deepakkumar
Publisher: name: Zenodo
Year: 2025

description: This study looks at the challenges faced by faculty members in Coimbatore as they try to balanceteaching and research, focusing on how salary and financial incentives affect this balance. It also exploreshow faculty research activities contribute to the academic success of students. The goal is to understandthese challenges better and offer recommendations that can help institutions support faculty in improvingboth their teaching and research, ultimately benefiting the overall academic environment. Data will becollected from 100 faculty members through questionnaires. The study will use t-tests to assess genderbased differences and percentage analysis to understand the role of salary and financial incentives andcorrelation analysis will explore how faculty research activities affect student academic performance.. Theresults will provide valuable insights into how these factors influence faculty workload and productivity,with recommendations for improving institutional support and financial structures.
A ‘deep dive’ into the SARS-Cov-2 polymerase assembly: identifying novel allosteric sites and analyzing the hydrogen bond networks and correlated dynamics
Creators: name: Barakat, Khaled
name: Ahmed, Marawan
name: Tabana, Yasser
name: Ha, Minwoo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Replication of the SARS-CoV-2 genome is a fundamental step in the virus life cycle and inhibiting the SARS-CoV2 replicase machinery has been proven recently as a promising approach in combating the virus. Despite this recent success, there are still several aspects related to the structure, function and dynamics of the CoV-2 polymerase that still need to be addressed. This includes understanding the dynamicity of the various polymerase subdomains, analyzing the hydrogen bond networks at the active site and at the template entry in the presence of water, studying the binding modes of the nucleotides at the active site, highlighting positions for acceptable nucleotides’ substitutions that can be tolerated at different positions within the nascent RNA strand, identifying possible allosteric sites within the polymerase structure and studying their correlated dynamics relative to the catalytic site. Here, we combined various cutting-edge modelling tools with the recently resolved SARS-CoV-2 cryo-EM polymerase structures to fill this gap in knowledge. Our findings provide a detailed analysis of the hydrogen bond networks at various parts of the polymerase structure and suggest possible nucleotides’ substitutions that can be tolerated by the polymerase complex. We also report here three ‘druggable’ allosteric sites within the NSP12 RdRp that can be targeted by small molecule inhibitors. Our correlated motion analysis shows that the dynamics within one of the newly identified sites are linked to the active site, indicating that targeting this site can significantly impact the catalytic activity of the SARS-CoV-2 polymerase. Communicated by Ramaswamy H. Sarma
Competitiveness of Ethiopian Shoe Industry: Response to Export Market
Creators: name: Gonfa, Birkinesh
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2012

description: Ethiopian Leather development strategy has put the shoe industry on the forefront position to accelerate the development of the sector. The study focuses on Ethiopian shoe industry competitiveness and its export market performance. The main purpose is to find the factors that are impediments for competitiveness of shoe industry at firm level and to find out the peculiar problems of shoe manufacturing in the export activities. Concepts of competitiveness and measures have been discussed. The Porter diamond model has been chosen to analyze firm level competitiveness. The result depicts the very low status of competitiveness of the Ethiopian shoe industry. At the firm level, all the determinants of competitiveness (Factor conditions, related and support industries, firm structure, strategy and rivalry, Demand conditions) are found to be insignificant. Among the factors, related and supporting industries and factor conditions mainly limit the firms from utilizing their cost advantage to sustained market share on the domestic as well as on the international market. The study foreword some recommendation or policy implication based on the analysis. Some of the major recommendations are: on the importance of import substitution strategy in complement with the export-oriented strategy is highly magnified in the study for the sector long run development. Promoting Investment on supporting Industries are crucial in solving problems in the whole value chain of the industry. Government involvement to create access to reliable and low cost of inputs and access to finance is crucial for shoe industry competitiveness. The other important area that needs an improvement is the quality of shoe products and utilization of PMA, here the importance of firms, government and other institutions collaborate with each other to tackle the problems is very crucial to improve the competitiveness of Ethiopian shoe industry.
A structure-based approach for the discovery of inhibitors against methylcitrate synthase of Paracoccidioides lutzii
Creators: name: Lima, Raisa Melo
name: Freitas e Silva, Kleber Santiago
name: do Carmo Silva, Lívia
name: Ribeiro, Jean Francisco Rosa
name: Neves, Bruno Junior
name: Brock, Matthias
name: de Almeida Soares, Célia Maria
name: da Silva, Roosevelt Alves
name: Pereira, Maristela
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in Latin America, caused by fungi of the genus Paracoccidioides. The treatment of PCM is complex, requiring a long treatment period, which often results in serious side effects. The aim of this study was to screen for inhibitors of a specific target of the fungus that is absent in humans. Methylcitrate synthase (MCS) is a unique enzyme of microorganisms and is responsible for the synthesis of methylcitrate at the beginning of the propionate degradation pathway. This pathway is essential for several microorganisms, since the accumulation of propionyl-CoA can impair virulence and prevent the development of the pathogen. We performed the modeling and molecular dynamics of the structure of Paracoccidioides lutzii MCS (PlMCS) and performed a virtual screening on 89,415 compounds against the active site of the enzyme. The compounds were selected according to the affinity and efficiency criteria of in vitro tests. Six compounds were able to inhibit the enzymatic activity of recombinant PlMCS but only the compound ZINC08964784 showed fungistatic and fungicidal activity against Paracoccidioides spp. cells. The analysis of the interaction profile of this compound with PlMCS showed its effectiveness in terms of specificity and stability when compared to the substrate (propionyl-CoA) of the enzyme. In addition, this compound did not show cytotoxicity in mammalian cells, with an excellent selectivity index. Our results suggest that the compound ZINC08964784 may become a promising alternative antifungal against Paracoccidioides spp. Communicated by Ramaswamy H. Sarma
A conditional likelihood is required to estimate the selection coefficient in ancient DNA
Creators: name: Valleriani, Angelo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Time-series of allele frequencies are a useful and unique set of data to determine the strength of natural selection on the background of genetic drift. Technically, the selection coefficient is estimated by means of a likelihood function built under the hypothesis that the available trajectory spans a sufficiently large portion of the fitness landscape. Especially for ancient DNA, however, often only one single such trajectories is available and the coverage of the fitness landscape is very limited. In fact, one single trajectory is more representative of a process conditioned both in the initial and in the final condition than of a process free to visit the available fitness landscape. Based on two models of population genetics, here we show how to build a likelihood function for the selection coefficient that takes the statistical peculiarity of single trajectories into account. We show that this conditional likelihood delivers a precise estimate of the selection coefficient also when allele frequencies are close to fixation whereas the unconditioned likelihood fails. Finally, we discuss the fact that the traditional, unconditioned likelihood always delivers an answer, which is often unfalsifiable and appears reasonable also when it is not correct.
description: 14 pages, 3 figures
The algal removal of nitrogen from wastewater effluents and the kinetics of nitrogen-limited algal growth
Creators: name: Skicko, John Ivan
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Determinants of Voluntary Environmentally Sound Technology Adoption and an Assessment of Dynamic Inconsistency in Adoption Decision in Industry in Ethiopia
Creators: name: Tafesse, Bernabas
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2010

description: The assessment of the determinants of the adoption of ESTs and the reasons for not adopting and continuity are explored in this paper. Towards the first question, four dimensions of possible determinants were identified. The variables that came out as most significant in the adoption decision are the ones pertaining to the plant characteristics of the firm. Specifically, the variables in this category are: the environmental commitment of the firm, the form of ownership of the firm as either foreigner owned or not and its arrangement as being either public or private, the technological capability of the firm, the number of years it has been in operation, and the number of employees. This underlines that the diversity of the firms plays a role in determining the EST option they adopt and thus imply the need for environmental policy to account for the heterogeneity of the firms in its design and implementation. This was done using the ordered probit model following the hierarchical nature of the response variables. Towards the second question, the heckman probit selection model is used and the results explained in the principal agent framework suggest that the form of management, among other things, does come into play in determining whether the firm continues with ESTs or not once they are adopted. This suggests that incentives or more generally the efficiency of mechanism design determines the effective implementation of a venture embarked upon despite the saving potential promised, and in cases savings earned, following the adoption of the ESTs. This implies the need for environmental policy to take into consideration internal management issues for effective realization of the environmental policy objectives drawn
Time-Dependent AdS Backgrounds from S-Branes
Creators: name: Deger, Nihat Sadik
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct time and radial dependent solutions that describe p-branes in chargeless S-brane backgrounds. In particular, there are some new M5- and D3-branes among our solutions which have AdS limits and contain a cosmological singularity as well. We also find a time-dependent version of the dyonic membrane configuration in 11-dimensions by applying a Lunin-Maldacena deformation to our new M5-brane solution.
description: 10 pages, v2: text improved, to appear in Phys.Lett. B
XX Международная научно-практическая конференция «Актуальные проблемы общества, экономики и права в контексте глобальных вызовов» ч.2.
Creators: name: ООО "Институт развития образования и консалтинга"
Publisher: name: ООО "Институт развития образования и консалтинга"
Year: 2023

description: XX Международная научно-практическая конференция «Актуальные проблемы общества, экономики и права в контексте глобальных вызовов» ч.2.
Refining of metals with sulphur
Creators: name: Simson, Harry Armstrong
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The development of inventory control systems for incoming and outgoing manufacturing logistics and decision rules for the stocking position in a two stage inventory system
Creators: name: Siajadi, Hans
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations
Creators: name: Aslan, Tolga
name: Yenenler-Kutlu, Aslı
name: Gerlevik, Umut
name: Zeybek, Ayşe Çiğdem Aktuğlu
name: Kıykım, Ertuğrul
name: Sezerman, Osman Uğur
name: Iyison, Necla Birgul
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Phenylketonuria is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase gene. In phenylketonuria causes various symptoms including severe mental retardation. PAH gene of a classical Phenylketonuria patient was sequenced, and two novel heterozygous mutations, p.Y198N and p.Y204F, were found. This study aimed to reveal the impacts of these variants on the structural stability of the PAH enzyme. In-silico analyses using prediction tools and molecular dynamics simulations were performed. Mutations were introduced to the wild type catalytic monomer and full length tetramer crystal structures. Variant pathogenicity analyses predicted p.Y198N to be damaging, and p.Y204F to be benign by some prediction tools and damaging by others. Simulations suggested p.Y198N mutation cause significant fluctuations in the spatial organization of two catalytic residues in the temperature accelerated MD simulations with the monomer and increased root-mean-square deviations in the tetramer structure. p.Y204F causes noticeable changes in the spatial positioning of T278 suggesting a possible segregation from the catalytic site in temperature accelerated MD simulations with the monomer. This mutation also leads to increased root-mean-square fluctuations in the regulatory domain which may lead to conformational change resulting in inhibition of dimerization and enzyme activation. Our study reports two novel mutations in the PAH gene and gives insight to their effects on the PAH activity. MD simulations did not yield conclusive results that explains the phenotype but gave plausible insight to possible effects which should be investigated further with in-silico and in-vitro studies to assess the roles of these mutations in etiology of PKU. Communicated by Ramaswamy H. Sarma
An investigation of Parkinson's disease using electrovestibulography
Creators: name: Shoushtarian, Mehrnaz
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Structurally distinct unfolding intermediates formed from a staphylococcal capsule-producing enzyme retained NADPH binding activity
Creators: name: Chakraborty, Tushar
name: Polley, Soumitra
name: Sinha, Debabrata
name: Seal, Soham
name: Sinha, Debasmita
name: Mitra, Sudip K
name: Hazra, Joyita
name: Sau, Keya
name: Pal, Mahadeb
name: Sau, Subrata
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: CapF, a capsule-producing enzyme expressed by Staphylococcus aureus, binds NADPH and exists as a dimer in the aqueous solution. Many other capsule-producing virulent bacteria also express CapF orthologs. To understand the folding-unfolding mechanism of S. aureus CapF, herein a recombinant CapF (rCapF) was individually investigated using urea and guanidine hydrochloride (GdnCl). Unfolding of rCapF by both the denaturants was reversible but proceeded via the synthesis of a different number of intermediates. While two dimeric intermediates (rCapF4 and rCapF5) were formed at 0.5 M and 1.5 M GdnCl, three dimeric intermediates (rCapF1, rCapF2, and rCapF3) were produced at 1 M, 2 M, and 3 M urea, respectively. rCapF5 showed 3.6 fold less NADPH binding activity, whereas other intermediates retained full NADPH binding activity. Compared to rCapF, all of the intermediates (except rCapF3) had a compressed shape. Conversely, rCapF3 possessed a native protein-like shape. The maximum shape loss was in rCapF4 though its secondary structure remained unperturbed. Additionally, the tertiary structure and hydrophobic surface area of the intermediates neither matched with each other nor with those of the native rCapF. Of the four Trp residues in rCapF, one or more Trp residues in the intermediates may have higher solvent accessibility. Using sequence alignment and a tertiary structural model of CapF, we have demonstrated that the region around Trp 137 of CapF may be most sensitive to unfolding, whereas the NADPH binding motif carrying region at the N-terminal end of this protein may be resistant to unfolding, particularly at the low denaturant concentrations. Communicated by Ramaswamy H. Sarma
Extension of the MURaM radiative MHD code for coronal simulations
Creators: name: Rempel, Matthias
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a new version of the MURaM radiative MHD code that allows for simulations spanning from the upper convection zone into the solar corona. We implemented the relevant coronal physics in terms of optically thin radiative loss, field aligned heat conduction and an equilibrium ionization equation of state. We artificially limit the coronal Alfv{é}n and heat conduction speeds to computationally manageable values using an approximation to semi-relativistic MHD with an artificially reduced speed of light (Boris correction). We present example solutions ranging from quiet to active Sun in order to verify the validity of our approach. We quantify the role of numerical diffusivity for the effective coronal heating. We find that the (numerical) magnetic Prandtl number determines the ratio of resistive to viscous heating and that owing to the very large magnetic Prandtl number of the solar corona, heating is expected to happen predominantly through viscous dissipation. We find that reasonable solutions can be obtained with values of the reduced speed of light just marginally larger than the maximum sound speed. Overall this leads to a fully explicit code that can compute the time evolution of the solar corona in response to photospheric driving using numerical time steps not much smaller than $0.1$ seconds. Numerical simulations of the coronal response to flux emergence covering a time span of a few days are well within reach using this approach.
description: 28 pages, 17 figures, submitted to ApJ
Oxidation of organic compounds in supercritical water : the role of water
Creators: name: Short, Graeme
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The Dynamics of Internationalization of Ethiopian Leather Industry Development Institute (ELIDI)
Creators: name: Abdulmejied, Abdurehaman
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2012

description: Nowadays there is a need for business enterprises to measure, analyze and improve performance as they encounter increasing competition from an ever-changing business environment. Performance is the valued productive output of a system in the form of goods and services and performance measures are the lifeblood of organizations, since without them no decision can be made, as it is the first step to control and improvement. Though the Government of Ethiopia is promoting the leather footwear industry as a priority area and the sector has a huge potential for developing an economy, its performance is unsatisfactory due to external and internal problems that hinder its competitiveness. Thus, the aim of this study is to assess and evaluate performance management practice of Ethiopian Leather Footwear Factories, identify critical problems and propose a firm level total performance improvement method and suggest roles of stakeholders or improvement directions towards the external problems. To undertake this research, primary and secondary data are collected through a survey questionnaire, interviews (in the form of discussion) and physical observation in the case factory, as well as referring previous research works and case company records. To analyze and present the data, pie charts, bar graphs, and diagrams are used. In addition, to see the performance gap of the case factory, benchmarking is done. From the research, it is concluded that the leather shoe factories have both internal and external problems resulting in low performance and competitiveness. To alleviate the internal or firm level problems, a total performance improvement method called Total Performance Scorecard (TPS) is proposed. In addition improvement directions are forwarded towards the external or sector level problems. Regarding the proposed method, a performance measurement framework/scorecards and its implementation guideline is developed for Anbessa S.C. TPS is a combination and also an extension of the concepts BSC, TQM and Competence Management which is being defined as a systematic process of continuous, gradual and routine improvement, development and learning. The process focused on the solid increase of both the personal and organizational performances. This method has an important aspect in maximizing the involvement and loyalty of all involved persons, as well as encouraging individual and team learning and creativity via its Personal Balanced Scorecard (PBSC).
Helix-coil transition and conformational deformity in Aβ42-monomer: a case study using the Zn2+ cation
Creators: name: Chowdhury, Unmesh D.
name: Bhargava, B. L.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Computational Biology

description: The metal ions (like Fe2+, Zn2+, Cu2+) are known to influence the amyloid beta (Aβ) aggregation. In this study, we have examined the conformational and dynamical changes during the coordination of Aβ-monomer with the Zn2+ ion using all-atom molecular dynamics (MD) simulations using explicit solvent models. We have probed the unfolding of the full-length Aβ42 monomer both inclusive and exclusive of the Zn2+ cation, with 1:1 ratio of the peptide and the Zn2+ cation. The inclusion of the Zn2+ cation shows differential intra-peptide interactions which has been probed using various analyses. The Helix – Coil transition of the wild type Aβ42 monomer is studied using the steered molecular dynamics simulations by taking the end-to-end C-α distance across the peptide. This gives an idea of the unequal intra – peptide and peptide – water interactions being found across the length of the Aβ monomer. The transition of an α-helix dominated wild-type (WT) Aβ structure to the unfolded coil structure gives significant evidence of the intra-peptide hydrogen bonding shifts in the presence of the Zn2+ cation. This accounts for the structural and the dynamical variations that take place in the Aβ monomer in the presence of the Zn2+ cation to mimic the conditions/environment at the onset of fibrillation. Communicated by Ramaswamy H. Sarma
Convolution surfaces in computer graphics
Creators: name: Sherstyuk, Andrei
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Unusual Fe-H bonding associated with oxygen vacancies at the (001) surface of Fe3O4
Creators: name: Liu, Fangyang
name: Chen, Chen
name: Guo, Hangwen
name: Saghayezhian, Mohammad
name: Wang, Gaomin
name: Chen, Lina
name: Chen, Wei
name: Zhang, Jiandi
name: Plummer, E. W.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: An unusual Fe-H bonding rather than conventional OH bonding is identified at Fe3O4 (001) surface. This abnormal behavior is associated with the oxygen vacancies which exist on the surface region but also penetrate deep into the bulk Fe3O4. In contrast, OH bonding becomes preferential as generally expected on an ozone processed surface, which has appreciably less oxygen vacancies. Such bonding site selective behavior, depending on oxygen vacancy concentrations, is further confirmed with DFT calculations. The results demonstrate an opportunity for tuning the chemical properties of oxide surfaces or oxide clusters.
A structure-based approach for the discovery of inhibitors against methylcitrate synthase of Paracoccidioides lutzii
Creators: name: Lima, Raisa Melo
name: Freitas e Silva, Kleber Santiago
name: Silva, Lívia do Carmo
name: Ribeiro, Jean Francisco Rosa
name: Neves, Bruno Junior
name: Brock, Matthias
name: de Almeida Soares, Célia Maria
name: da Silva, Roosevelt Alves
name: Pereira, Maristela
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in Latin America, caused by fungi of the genus Paracoccidioides. The treatment of PCM is complex, requiring a long treatment period, which often results in serious side effects. The aim of this study was to screen for inhibitors of a specific target of the fungus that is absent in humans. Methylcitrate synthase (MCS) is a unique enzyme of microorganisms and is responsible for the synthesis of methylcitrate at the beginning of the propionate degradation pathway. This pathway is essential for several microorganisms, since the accumulation of propionyl-CoA can impair virulence and prevent the development of the pathogen. We performed the modeling and molecular dynamics of the structure of Paracoccidioides lutzii MCS (PlMCS) and performed a virtual screening on 89,415 compounds against the active site of the enzyme. The compounds were selected according to the affinity and efficiency criteria of in vitro tests. Six compounds were able to inhibit the enzymatic activity of recombinant PlMCS but only the compound ZINC08964784 showed fungistatic and fungicidal activity against Paracoccidioides spp. cells. The analysis of the interaction profile of this compound with PlMCS showed its effectiveness in terms of specificity and stability when compared to the substrate (propionyl-CoA) of the enzyme. In addition, this compound did not show cytotoxicity in mammalian cells, with an excellent selectivity index. Our results suggest that the compound ZINC08964784 may become a promising alternative antifungal against Paracoccidioides spp. Communicated by Ramaswamy H. Sarma
Building Leadership Capacity Among Women
Creators: Solomiya Cherkavska
Publisher: name: University of Alberta Library
Year: 2023

This qualitative study addresses the underrepresentation of women as school principals, despite teaching being perceived as a feminine profession. The primary objective was to investigate why women with leadership skills choose to remain in the classroom rather than pursue leadership positions. The study aimed to examine pathways of female teachers to school leadership, specifically the principalship, and to suggest practical solutions to support women’s aspirations to enter these roles. The research methodology involved collecting data through interviews, and the analysis entailed identifying emergent themes focused on strategies for building leadership capacity among women in schools. The interview results concluded that there are leadership opportunities accessible for individuals who actively seek them. Participants highlighted both the factors contributing to success and the challenges they encounter. By identifying and addressing them, candidates, school leaders, and organizations can develop a more inclusive and gender- balanced educational leadership landscape.
Biological treatment of dairy whey
Creators: name: Sewards, Gordon J.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Prospects for Primordial Gravitational Waves in String Inflation
Creators: name: Parameswaran, Susha L.
name: Zavala, Ivonne
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Assuming that the early universe had (i) a description using perturbative string theory and its field theory limit (ii) an epoch of slow-roll inflation within a four-dimensional effective field theory and a hierarchy of scales $M_{inf} < m_{kk} < m_s \lesssim M_{pl}$ that keeps the latter under control, we derive an upper bound on the amplitude of primordial gravitational waves. The bound is very sensitive to mild changes in numerical coefficients and the expansion parameters. For example, allowing couplings and mass-squared hierarchies $\lesssim 0.2$, implies $r \lesssim 0.05$, but asking more safely for hierarchies $\lesssim 0.1$, the bound becomes $r \lesssim 10^{-6}$. Moreover, large volumes -- typically used in string models to keep backreaction and moduli stabilisation under control -- drive $r$ down. Consequently, any detection of inflationary gravitational waves would present an interesting but difficult challenge for string theory.
description: Received Honourable Mention in the 2016 Gravity Research Foundation Awards for Essays on Gravitation; submitted to IJMPD Special issue with some revisions and clarifications, 3 pages + refs; v2 further clarifications
The solidification microstructures of Al-Si based metal matrix composites
Creators: name: Setargew, Nega
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Structural characterization of cassava linamarase-linamarin enzyme complex: an integrated computational approach
Creators: name: Paul, L.
name: Shadrack, D. M.
name: Mudogo, C. N.
name: Mtei, K. M.
name: Machunda, R. L.
name: Ntie-Kang, F.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Cassava linamarase is a hydrolyzing enzyme that belongs to a glycoside hydrolase family 1 (GH1). It is responsible for breaking down linamarin to toxic cyanide. The enzyme provides a defensive mechanism for plants against herbivores and has various applications in many fields. Understanding the structure of linamarase at the molecular level is a key to avail its reaction mechanism. In this study, the three-dimensional (3D) structure of linamarase was built for the first time using homology modelling and used to study its interaction with linamarin. Molecular docking calculations established the binding and orientation nature of linamarin, while molecular dynamics (MD) simulation established protein-ligand complexes' stability. Binding-free energy based on MM/PBSA was further used to rescore the docking results. An ensemble structure was found to be relatively stable compared to the modelled structure. This study sheds light on the exploration of linamarase towards understanding its reaction mechanisms. Communicated by Ramaswamy H. Sarma
MPEC 2023-L04 : 2023 KO5
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 KO5

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Psychosocial health risk factors and resources of medical students and physicians
title: a cross-sectional study
titleType: Subtitle
Creators: name: Voltmer, Edgar
name: Kieschke, Ulf
name: Schwappach, David L.B.
name: Wirsching, Michael
name: Spahn, Claudia
Publisher: name: Universität Potsdam
Year: 2020

description: Background Epidemiological data indicate elevated psychosocial health risks for physicians, e.g., burnout, depression, marital disturbances, alcohol and substance abuse, and suicide. The purpose of this study was to identify psychosocial health resources and risk factors in profession-related behaviour and experience patterns of medical students and physicians that may serve as a basis for appropriate health promoting interventions. Methods The questionnaire -Related Behaviour and Experience "Work administered in cross-sectional surveys to students in the first (n = 475) and in the fifth year of studies (n = 355) in required courses at three German universities and to physicians in early professional life in the vicinity of these universities (n = 381). Results Scores reflecting a healthy behaviour pattern were less likely in physicians (16.7%) compared to 5th year (26.0%) and 1st year students (35.1%) while scores representing unambitious and resigned patterns were more common among physicians (43.4% vs. 24.4% vs. 41.0% and 27.3% vs. 17.2% vs. 23.3 respectively). Female and male responders differed in the domains professional commitment, resistance to stress and emotional well-being. Female physicians on average scored higher in the dimensions resignation tendencies, satisfaction with life and experience of social support, and lower in career ambition. Conclusion The results show distinct psychosocial stress patterns among medical students and physicians. Health promotion and prevention of psychosocial symptoms and impairments should be integrated as a required part of the medical curriculum and be considered an important issue during the further training of physicians.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 641