cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Elasticity of Fractal Material by Continuum Model with Non-Integer Dimensional Space
Creators: name: Tarasov, Vasily E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Using a generalization of vector calculus for space with non-integer dimension, we consider elastic properties of fractal materials. Fractal materials are described by continuum models with non-integer dimensional space. A generalization of elasticity equations for non-integer dimensional space, and its solutions for equilibrium case of fractal materials are suggested. Elasticity problems for fractal hollow ball and cylindrical fractal elastic pipe with inside and outside pressures, for rotating cylindrical fractal pipe, for gradient elasticity and thermoelasticity of fractal materials are solved.
description: 28 pages, LaTeX. arXiv admin note: substantial text overlap with arXiv:1503.02022, arXiv:1503.02842
Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
Creators: name: Stainier, Didier Y.R.
name: Givens, Chris
name: Qian, Li
name: Liu, Jiandong
name: Samsa, Leigh Ann
name: Tzima, Eleni
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Congenital heart disease often features structural abnormalities that emerge during development. Accumulating evidence indicates a crucial role for cardiac contraction and the resulting fluid forces in shaping the heart, yet the molecular basis of this function is largely unknown. Using the zebrafish as a model of early heart development, we investigated the role of cardiac contraction in chamber maturation, focusing on the formation of muscular protrusions called trabeculae. By genetic and pharmacological ablation of cardiac contraction, we showed that cardiac contraction is required for trabeculation through its role in regulating notch1b transcription in the ventricular endocardium. We also showed that Notch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and that forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression. Using in vitro and in vivo systems, we showed that primary cilia are important mediators of fluid flow to stimulate Notch expression. Together, our findings describe an essential role for cardiac contraction-responsive transcriptional changes in endocardial cells to regulate cardiac chamber maturation.
Implications of post-kick jets in core collapse supernovae
Creators: name: Soker, Noam
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: I examine the assumption that the jets that shape the axisymmetrical morphological features of core collapse supernova (CCSN) remnants are post-kick jets, i.e., the neutron star (NS) launches these jets after the explosion and after it acquired its natal kick velocity. I find that this assumption implies that the pre-collapse cores of CCSN progenitors have sufficient angular momentum fluctuations to support jittering jets that explode the star. From the finding that the shaping-jets neither tend to be aligned with the kick velocity nor to be perpendicular to it I argue that the assumption that the shaping-jets are post-kick jets has the following implications. (1) The NS accretes mass at a radius of ~5000km from the center of the explosion at ~10 s after explosion. (2) The required angular momentum fluctuations of the accreted gas to explain the medium values of jets-kick angles are also sufficient to support an intermittent pre-kick accretion disk, just before and during the explosion. Such an intermittent accretion disk is likely to launch jets that explode the star in the frame of the jittering jets explosion mechanism. This suggests that most likely the shaping-jets are the last jets in the jittering jets explosion mechanism rather than post-kick jets. (3) The jittering jets explosion mechanism expects that black holes have small natal kick velocities.
description: Accepted for publication in MNRAS
Hyperbolicity Measures "Democracy" in Real-World Networks
Creators: name: Borassi, Michele
name: Chessa, Alessandro
name: Caldarelli, Guido
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We analyze the hyperbolicity of real-world networks, a geometric quantity that measures if a space is negatively curved. In our interpretation, a network with small hyperbolicity is "aristocratic", because it contains a small set of vertices involved in many shortest paths, so that few elements "connect" the systems, while a network with large hyperbolicity has a more "democratic" structure with a larger number of crucial elements. We prove mathematically the soundness of this interpretation, and we derive its consequences by analyzing a large dataset of real-world networks. We confirm and improve previous results on hyperbolicity, and we analyze them in the light of our interpretation. Moreover, we study (for the first time in our knowledge) the hyperbolicity of the neighborhood of a given vertex. This allows to define an "influence area" for the vertices in the graph. We show that the influence area of the highest degree vertex is small in what we define "local" networks, like most social or peer-to-peer networks. On the other hand, if the network is built in order to reach a "global" goal, as in metabolic networks or autonomous system networks, the influence area is much larger, and it can contain up to half the vertices in the graph. In conclusion, our newly introduced approach allows to distinguish the topology and the structure of various complex networks.
Towards a reliable calculation of relic radiation from primordial gravitational waves
Creators: name: Giarè, William
name: Forconi, Matteo
name: Di Valentino, Eleonora
name: Melchiorri, Alessandro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Inflationary gravitational waves, behaving as additional radiation in the Early Universe, can increase the effective number of relativistic species ($N_{\rm eff}$) by a further correction that depends on the integrated energy-density in gravitational waves over all scales. This effect is typically used to constrain (blue-tilted) models of inflation in light of the bounds resulting from the Big Bang Nucleosynthesis. In this paper, we recompute this contribution, discussing some caveats of the state-of-the-art analyses. Through a parametric investigation, we first demonstrate that the calculation is dominated by the ultraviolet frequencies of the integral and therefore by the behavior of the tensor spectrum on scales corresponding to modes that cross the horizon very close to the end of inflation, when the slow-roll dynamics breaks down and the production of gravitational waves becomes strongly model dependent. Motivated by these results, we realize a theoretical Monte Carlo and, working within the framework of the Effective Field Theory of inflation, we investigate the observable predictions of a very broad class of models. For each model, we solve a system of coupled differential equations whose solution completely specifies the evolution of the spectrum up to the end of inflation. We prove the calculation of $ΔN_{\rm eff}^{\rm GW}$ to be remarkably model-dependent and therefore conclude that accurate analyses are needed to infer reliable information on the inflationary Universe.
description: 17 pages, 7 figures, 1 table. Updated to match the MNRAS published version
Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development
Creators: name: Conlon, Frank L.
name: Kuchenbrod, Lauren M.
name: Amin, Nirav M.
name: Charpentier, Marta S.
name: Labiner, Hanna
name: Dorr, Kerry M.
name: Wessels, Andy
name: Pevny, Larysa H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Organ growth occurs through the integration of external growth signals during the G1 phase of the cell cycle to initiate DNA replication. Although numerous growth factor signals have been shown to be required for the proliferation of cardiomyocytes, genetic studies have only identified a very limited number of transcription factors that act to regulate the entry of cardiomyocytes into S phase. Here, we report that the cardiac para-zinc-finger protein CASZ1 is expressed in murine cardiomyocytes. Genetic fate mapping with an inducible Casz1 allele demonstrates that CASZ1-expressing cells give rise to cardiomyocytes in the first and second heart fields. We show through the generation of a cardiac conditional null mutation that Casz1 is essential for the proliferation of cardiomyocytes in both heart fields and that loss of Casz1 leads to a decrease in cardiomyocyte cell number. We further report that the loss of Casz1 leads to a prolonged or arrested S phase, a decrease in DNA synthesis, an increase in phospho-RB and a concomitant decrease in the cardiac mitotic index. Taken together, these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.
MEMORIAS DE UNA CANTANTE ALEMANA (3ª ED.) leer el libro
Creators: name: Whiteley
Publisher: name: Zenodo
Year: 2024

description: MEMORIAS DE UNA CANTANTE ALEMANA (3ª ED.) de WILHELMINE SCHROEDER-DEVRIENT

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MEMORIAS DE UNA CANTANTE ALEMANA (3ª ED.)

WILHELMINE SCHROEDER-DEVRIENT

Número de páginas: 266

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788472233027

Editorial: TUSQUETS EDITORES

Año de edición: 1977

 

 

 

 

 

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Overview

Memorias de una cantante alemana , publicadas por primera vez en Altona en 1862, sigue siendo el libro más apreciado de la literatura erótica germana. Han sido atribuidas a la famosa cantante Wilhelmine Schroeder-Devrient quien, junto a la Sonntag, arrancaba las máximas ovaciones del público de su tiempo. La investigación apasionada de múltiples eruditos, a través de los años, ha demostrado la identidad del estilo de la célebre cantante con el de las Memorias. Estas fueron concebidas en forma de cartas dirigidas a un médico de renombre en su época, único hombre que, según señala la autora, no pretendió jamás a sus encantos. (El prólogo del destinatario, que aquí también reproducimos, contradice esta afirmación.)
Building our national digital research infrastructure - ORCID and the National Persistent Identifier (PID) Strategy and Roadmap
Creators: name: , Almeida
name: , O'Brien
name: , Simons
Publisher: name: Zenodo
Year: 2023
Subjects: ORCID
PIDs
persistent identifiers

description: Presentation at the annual Therapeutic Innovation Australia (TIA) Forum 2023 on ORCID, National PID Strategy and Roadmap.
DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans
Creators: name: Narbonne, Patrick
name: Labbé, Jean Claude
name: Maddox, Paul S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: During development, stem cell populations rapidly proliferate to populate the expanding tissues and organs. During this phase, nutrient status, by systemically affecting insulin/IGF-1 signalling, largely dictates stem cell proliferation rates. In adults, however, differentiated stem cell progeny requirements are generally reduced and vary according to the spatiotemporal needs of each tissue. We demonstrate here that differential regulation of germline stem cell proliferation rates in
Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication
Creators: name: Swanson, Christina I.
name: Thieme, Alexis
name: McCarter, Patrick C.
name: Duronio, Robert J.
name: Elston, Timothy C.
name: Meserve, Joy H.
name: Mathew, Tony
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In developing organisms, divergence from the canonical cell division cycle is often necessary to ensure the proper growth, differentiation, and physiological function of a variety of tissues. An important example is endoreplication, in which endocycling cells alternate between G and S phase without intervening mitosis or cytokinesis, resulting in polyploidy. Although significantly different from the canonical cell cycle, endocycles use regulatory pathways that also function in diploid cells, particularly those involved in S phase entry and progression. A key S phase regulator is the Cyclin E-Cdk2 kinase, which must alternate between periods of high (S phase) and low (G phase) activity in order for endocycling cells to achieve repeated rounds of S phase and polyploidy. The mechanisms that drive these oscillations of Cyclin E-Cdk2 activity are not fully understood. Here, we show that the Drosophila Cyclin E-Cdk2 inhibitor Dacapo (Dap) is targeted for destruction during S phase via a PIP degron, contributing to oscillations of Dap protein accumulation during both mitotic cycles and endocycles. Expression of a PIP degron mutant Dap attenuates endocycle progression but does not obviously affect proliferating diploid cells. A mathematical model of the endocycle predicts that the rate of destruction of Dap during S phase modulates the endocycle by regulating the length of G phase. We propose from this model and our in vivo data that endo S phase-coupled destruction of Dap reduces the threshold of Cyclin E-Cdk2 activity necessary to trigger the subsequent G-S transition, thereby influencing endocycle oscillation frequency and the extent of polyploidy.
Chemistry Teacher Interest: A Crucial Factor in Chemistry Education and Development in Nigeria
Creators: name: Okereke, , Victor Anochirim
Publisher: name: GO JOURNAL
Year: 2024
Subjects: Chemistry, interest, teacher education, development

description: The purpose of this paper is to highlight interest as an element of development and it’s consequence on teacher education and development. This opinion paper considers students’ interest in teaching as a profession despite the positive enrollment statistics, so as to contribute and stimulate debate and discussion, and offer new perspective and insights. Literature review and expert opinions methods were used to support the author’s opinion. Results were synthesized to support the author’s opinion on interest and it’s benefits to chemistry teacher education and development, factors responsible for students lack of interest on teaching discussed into; the country’s poor educational system, mini salaries/remuneration, desire to get money quick, love for soft work, discouraging testimonies from teachers/educators in the system, lack of prestige associated with the profession, and lack of models. The consequences have negative effect on teacher’s education and development in general and chemistry teacher’s education and development in particular which has resulted to production of graduates with education certificate but without interest in the profession. Ways to improve and sustain students’ interest were recommended. However, if the recommendations are implemented, it will move teachers from lamentation stage to the stage of influence
Supplementary Tables from Physical trade-offs shape the evolution of buoyancy control in sharks
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
(2955) Maud Elsie Schofield
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The unquenched QM
Creators: name: Santopinto, E.
name: Bijker, R.
name: García-Tecocoatzi, H.
name: Ferretti, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this contribution, we briefly analyze the formalism of the unquenched quark model (UQM) and its application to the calculation of hadron spectra with self-energy corrections, due to the coupling to the meson-meson continuum. In the UQM, the effects of $q \bar q$ sea pairs are introduced explicitly into the quark model through a QCD-inspired $^{3}P_0$ pair-creation mechanism. The UQM formalism can be extended to include also the effects of hybrid mesons, i.e. hybrid loops. The main applications to spectroscopy and decays are analyzed.
description: Presented at EEF70, Workshop on Unquenched Hadron Spectroscopy: Non-Perturbative Models and Methods of QCD vs. Experiment on the occasion of Eef van Beveren's 70th birthday, 1-5 September 2014, University of Coimbra, Portugal. arXiv admin note: substantial text overlap with arXiv:1503.02968
Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes
Creators: name: Kim, Yuna
name: Magnuson, Terry
name: Fedoriw, Andrew M.
name: Menon, Debashish
name: Mu, Weipeng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Meiotic silencing of unpaired chromatin (MSUC) occurs during the first meiotic prophase, as chromosomes that fail to pair are sequestered into a transcriptionally repressive nuclear domain. This phenomenon is exemplified by the heterologous sex chromosomes of male mammals, where the ATR DNA damage response kinase is crucial for this silencing event. However, the mechanisms underlying the initiation of MSUC remain unknown. Here, we show that essential components of ATR signaling in murine somatic cells are spatially confined to unpaired chromosomes in spermatocytes, including the ATR-dependent phosphorylation of the single-stranded DNA (ssDNA)-binding complex replication protein A (RPA) and the checkpoint kinase CHK1. These observations support a model in which ssDNA plays a central role in the recruitment of ATR during MSUC, and provide a link to meiotic progression through activation of CHK1.
Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans
Creators: name: Hardin, Jeff
name: Reiner, David
name: Walck-Shannon, Elise
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cell intercalation is a fundamental, coordinated cell rearrangement process that shapes tissues throughout animal development. Studies of intercalation within epithelia have focused almost exclusively on the localized constriction of specific apical junctions. Another widely deployed yet poorly understood alternative mechanism of epithelial intercalation relies on basolateral protrusive activity. Using the dorsal embryonic epidermis of
Supplementary Methods: Comparative Data from Physical trade-offs shape the evolution of buoyancy control in sharks
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage
Creators: name: Meserve, Joy H.
name: Duronio, Robert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Regeneration of damaged tissues typically requires a population of active stem cells. How damaged tissue is regenerated in quiescent tissues lacking a stem cell population is less well understood. We used a genetic screen in the developing Drosophila melanogaster eye to investigate the mechanisms that trigger quiescent cells to re-enter the cell cycle and proliferate in response to tissue damage. We discovered that Hippo signaling regulates compensatory proliferation after extensive cell death in the developing eye. Scalloped and Yorkie, transcriptional effectors of the Hippo pathway, drive Cyclin E expression to induce cell cycle re-entry in cells that normally remain quiescent in the absence of damage. Ajuba, an upstream regulator of Hippo signaling that functions as a sensor of epithelial integrity, is also required for cell cycle re-entry. Thus, in addition to its well-established role in modulating proliferation during periods of tissue growth, Hippo signaling maintains homeostasis by regulating quiescent cell populations affected by tissue damage.
Supplementary Figures from Physical trade-offs shape the evolution of buoyancy control in sharks
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
ECAP-Supplementary
Creators: Erik Brorsson
Knut Åkesson
Lennart Svensson
Kristofer Bengtsson
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: We consider unsupervised domain adaptation (UDA) for semantic segmentation in which the model is trained on a labeled source dataset and adapted to an unlabeled target dataset. Unfortunately, current self-training methods are susceptible to misclassified pseudo-labels resulting from erroneous predictions. Since certain classes are typically associated with less reliable predictions in UDA, reducing the impact of such pseudo-labels without skewing the training towards some classes is notoriously difficult. 
To this end, we propose an extensive cut-and-paste strategy (ECAP) to leverage reliable pseudo-labels through data augmentation.
Specifically, ECAP maintains a memory bank of pseudo-labeled target samples throughout training and cut-and-pastes the most confident ones onto the current training batch. We implement ECAP on top of the recent method MIC and boost its performance on two synthetic-to-real domain adaptation benchmarks. Notably, MIC+ECAP reaches an unprecedented performance of 69.1 mIoU on the Synthia→Cityscapes benchmark. Our code is available at https://github.com/ErikBrorsson/ECAP.
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
Creators: name: Randell, Scott H.
name: Rock, Jason R.
name: Hogan, Brigid L.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. These clinical problems impose huge personal and societal healthcare burdens. The changes, termed ‘pathological airway remodeling’, affect the epithelium, the underlying mesenchyme and the reciprocal trophic interactions that occur between these tissues. Most of the normal human airway is lined by a pseudostratified epithelium of ciliated cells, secretory cells and 6–30% basal cells, the proportion of which varies along the proximal-distal axis. Epithelial abnormalities range from hypoplasia (failure to differentiate) to basal- and goblet-cell hyperplasia, squamous- and goblet-cell metaplasia, dysplasia and malignant transformation. Mesenchymal alterations include thickening of the basal lamina, smooth muscle hyperplasia, fibrosis and inflammatory cell accumulation. Paradoxically, given the prevalence and importance of airway remodeling in lung disease, its etiology is poorly understood. This is due, in part, to a lack of basic knowledge of the mechanisms that regulate the differentiation, maintenance and repair of the airway epithelium. Specifically, little is known about the proliferation and differentiation of basal cells, a multipotent stem cell population of the pseudostratified airway epithelium. This Perspective summarizes what we know, and what we need to know, about airway basal cells to evaluate their contributions to normal and abnormal airway remodeling. We contend that exploiting well-described model systems using both human airway epithelial cells and the pseudostratified epithelium of the genetically tractable mouse trachea will enable crucial discoveries regarding the pathogenesis of airway disease.
Figure S2 from Variably hungry caterpillars: predictive models and foliar chemistry suggest how to eat a rainforest.
Creators: name: Segar, Simon T.
name: Volf, Martin
name: Brus Isua
name: Mentap Sisol
name: Redmond, Conor M.
name: Rosati, Margaret E.
name: Gewa, Bradley
name: Molem, Kenneth
name: Dahl, Chris
name: Holloway, Jeremy D.
name: Basset, Yves
name: Miller, Scott E.
name: Weiblen, George
name: Juha-Pekka Salminen
name: Novotny, Vojtech
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The phylogeny of plant hosts sampled for either geometrids or pyraloids. The 34 hosts only sampled in the Wanang data set are marked with a star. Branch lengths are equal to substitutions per site.
Supplementary Methods: Hydrodynamic Modeling from Physical trade-offs shape the evolution of buoyancy control in sharks
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
Figure S3 from Variably hungry caterpillars: predictive models and foliar chemistry suggest how to eat a rainforest.
Creators: name: Segar, Simon T.
name: Volf, Martin
name: Brus Isua
name: Mentap Sisol
name: Redmond, Conor M.
name: Rosati, Margaret E.
name: Gewa, Bradley
name: Molem, Kenneth
name: Dahl, Chris
name: Holloway, Jeremy D.
name: Basset, Yves
name: Miller, Scott E.
name: Weiblen, George
name: Juha-Pekka Salminen
name: Novotny, Vojtech
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The phylogeny of pyraloids sampled in this study and used for analysis. The species only sampled in the Wanang data set is marked with a star. Branch lengths are equal to substitutions per site.
Glafenine-induced intestinal injury in zebrafish is ameliorated by  -opioid signaling via enhancement of Atf6-dependent cellular stress responses
Creators: name: Goldsmith, Jason R.
name: Jobin, Christian
name: Cocchiaro, Jordan L.
name: Rawls, John F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Beside their analgesic properties, opiates exert beneficial effects on the intestinal wound healing response. In this study, we investigated the role of μ-opioid receptor (MOR) signaling on the unfolded protein response (UPR) using a novel zebrafish model of NSAID-induced intestinal injury. The NSAID glafenine was administered to zebrafish larvae at 5 days post-fertilization (dpf) for up to 24 hours in the presence or absence of the MOR-specific agonist DALDA. By analysis with histology, transmission electron microscopy and vital dye staining, glafenine-treated zebrafish showed evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen. Although the early UPR marker BiP was induced with glafenine-induced injury, downstream atf6 and s-xbp1 expression were paradoxically not increased, explaining the halted cell stress responses. The μ-opioid agonist DALDA protected against glafenine-induced injury through induction of atf6-dependent UPR. Our findings show that DALDA prevents glafenine-induced epithelial damage through induction of effective UPR.
(2951) Robert Reaveley Thackeray
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Figure S9 from Variably hungry caterpillars: predictive models and foliar chemistry suggest how to eat a rainforest.
Creators: name: Segar, Simon T.
name: Volf, Martin
name: Brus Isua
name: Mentap Sisol
name: Redmond, Conor M.
name: Rosati, Margaret E.
name: Gewa, Bradley
name: Molem, Kenneth
name: Dahl, Chris
name: Holloway, Jeremy D.
name: Basset, Yves
name: Miller, Scott E.
name: Weiblen, George
name: Juha-Pekka Salminen
name: Novotny, Vojtech
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Correlations between Euclidean distance matrices derived from observed and predicted association between plant hosts a i) geometrid caterpillars (r=0.72, p=0.001) and ii) pyraloid caterpillars (r=0.94, p=0.001).
Mucosal candidiasis elicits NF- B activation, proinflammatory gene expression and localized neutrophilia in zebrafish
Creators: name: Gratacap, Remi L.
name: Wheeler, Robert T.
name: Rawls, John F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: SUMMARYThe epithelium performs a balancing act at the interface between an animal and its environment to enable both pathogen killing and tolerance of commensal microorganisms. Candida albicans is a clinically important human commensal that colonizes all human mucosal surfaces, yet is largely prevented from causing mucosal infections in immunocompetent individuals. Despite the importance of understanding host-pathogen interactions at the epithelium, no immunocompetent vertebrate model has been used to visualize these dynamics non-invasively. Here we demonstrate important similarities between swimbladder candidiasis in the transparent zebrafish and mucosal infection at the mammalian epithelium. Specifically, in the zebrafish swimmbladder infection model, we show dimorphic fungal growth, both localized and tissue-wide epithelial NF-κB activation, induction of NF-κB -dependent proinflammatory genes, and strong neutrophilia. Consistent with density-dependence models of host response based primarily on tissue culture experiments, we show that only high-level infection provokes widespread activation of NF-κB in epithelial cells and induction of proinflammatory genes. Similar to what has been found using in vitro mammalian models, we find that epithelial NF-κB activation can occur at a distance from the immediate site of contact with epithelial cells. Taking advantage of the ability to non-invasively image infection and host signaling at high resolution, we also report that epithelial NF-κB activation is diminished when phagocytes control the infection. This is the first system to model host response to mucosal infection in the juvenile zebrafish, and offers unique opportunities to investigate the tripartite interactions of C. albicans, epithelium and immune cells in an intact host.
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Publisher: name: Zenodo
Year: 2024

description: ORGANIZAR CENTROS ESCOLARES de ROSA MARÍA SANTAMARÍA CONDE

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ORGANIZAR CENTROS ESCOLARES

ROSA MARÍA SANTAMARÍA CONDE

Idioma: CASTELLANO

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ISBN: 9788413576435

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Descargar libros electrónicos gratis en ingles ORGANIZAR CENTROS ESCOLARES (Literatura española) 9788413576435

 

Overview

En esta obra se detallan los diferentes elementos implicados en la organización de los centros escolares, teniendo en cuenta la actual legislación vigente (LOE, 2006 y LOMLOE, 2020). El contenido se estructura en torno a ocho capítulos en los que se van desgranando aspectos tales como la evolución histórica de la organización escolar en general y de la escuela en particular, la incidencia de la legislación escolar, la organización de los recursos humanos, materiales y funcionales, la elaboración de los documentos institucionales, la evaluación de los centros, así como la organización de la escuela rural y de las escuelas de educación infantil, todo ello expuesto de una manera clara y coherente. Cada capítulo se complementa con la propuesta de unas actividades para la reflexión, con el objeto de aunar la teoría con la práctica. Este libro está dirigido al alumnado de los grados de Maestro y Pedagogía, al tiempo que constituye un valioso material para todos los maestros y maestras, así como demás profesionales interesados en la organización de centros escolares. Rosa M.ª Santamaría Conde es profesora titular del área de Didáctica y Organización Escolar del Departamento de Ciencias de la Educación de la Universidad de Burgos.
Unveiling the nature of the unidentified gamma-ray sources VI: gamma-ray blazar candidates in the WISH survey and their radio properties
Creators: name: Nori, M.
name: Giroletti, M.
name: Massaro, F.
name: D'Abrusco, R.
name: Paggi, A.
name: Tosti, G.
name: Funk, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: According to the second Fermi LAT Catalog (2FGL), about one third of the gamma-ray sources listed have no assigned counterparts at lower energies. Many statistical methods have been developed to find proper counterparts for these sources. We explore the sky area covered at low radio frequency by Westerbork in the Southern Hemisphere (WISH) survey to search for blazar-like associations among the unidentified gamma-ray sources listed in the 2FGL (UGSs). Searching the WISH and NRAO VLA Sky Survey (NVSS) radio surveys within the positional uncertainty regions of the 2FGL UGSs, we select as gamma-ray blazar candidates the radio sources characterized by flat radio spectra between 352 MHz and 1400 MHz. We propose new gamma-ray blazar associations for eight UGSs and we also discuss their spectral properties at low radio frequencies. We compare the radio flux density distribution of the low radio frequency gamma-ray blazar candidates with that of gamma-ray blazars associated with other methods. We find significant differences between these distributions. Finally, we discuss the results of this association method and its possible applicability to other regions of the sky and future radio surveys.
description: 8 pages, 4 figures, 4 tables, ApJS published in 2014 (pre-proof version uploaded)
Figure S4 from Variably hungry caterpillars: predictive models and foliar chemistry suggest how to eat a rainforest.
Creators: name: Segar, Simon T.
name: Volf, Martin
name: Brus Isua
name: Mentap Sisol
name: Redmond, Conor M.
name: Rosati, Margaret E.
name: Gewa, Bradley
name: Molem, Kenneth
name: Dahl, Chris
name: Holloway, Jeremy D.
name: Basset, Yves
name: Miller, Scott E.
name: Weiblen, George
name: Juha-Pekka Salminen
name: Novotny, Vojtech
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The phylogeny of geometrids sampled in this study and used for analysis. The species only sampled in the Wanang data set is marked with a star. Branch lengths are equal to substitutions per site.
Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)
Creators: name: Sherwood, Nina Tang
name: Crowl, Christopher
name: Allard, Denise E.
name: Baxter, Sally L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Autosomal-dominant hereditary spastic paraplegia (AD-HSP) is a crippling neurodegenerative disease for which effective treatment or cure remains unknown. Victims experience progressive mobility loss due to degeneration of the longest axons in the spinal cord. Over half of AD-HSP cases arise from loss-of-function mutations in spastin, which encodes a microtubule-severing AAA ATPase. In Drosophila models of AD-HSP, larvae lacking Spastin exhibit abnormal motor neuron morphology and function, and most die as pupae. Adult survivors display impaired mobility, reminiscent of the human disease. Here, we show that rearing pupae or adults at reduced temperature (18°C), compared with the standard temperature of 24°C, improves the survival and mobility of adult spastin mutants but leaves wild-type flies unaffected. Flies expressing human spastin with pathogenic mutations are similarly rescued. Additionally, larval cooling partially rescues the larval synaptic phenotype. Cooling thus alleviates known spastin phenotypes for each developmental stage at which it is administered and, notably, is effective even in mature adults. We find further that cold treatment rescues larval synaptic defects in flies with mutations in Flower (a protein with no known relation to Spastin) and mobility defects in flies lacking Kat60-L1, another microtubule-severing protein enriched in the CNS. Together, these data support the hypothesis that the beneficial effects of cold extend beyond specific alleviation of Spastin dysfunction, to at least a subset of cellular and behavioral neuronal defects. Mild hypothermia, a common neuroprotective technique in clinical treatment of acute anoxia, might thus hold additional promise as a therapeutic approach for AD-HSP and, potentially, for other neurodegenerative diseases.
Plant phylogeny from Varyingly hungry caterpillars: predictive models and foliar chemistry suggest how to eat a rainforest
Creators: name: Segar, Simon T.
name: Volf, Martin
name: Brus Isua
name: Mentap Sisol
name: Redmond, Conor M.
name: Rosati, Margaret E.
name: Gewa, Bradley
name: Molem, Kenneth
name: Dahl, Chris
name: Holloway, Jeremy D.
name: Basset, Yves
name: Miller, Scott E.
name: Weiblen, George
name: Juha-Pekka Salminen
name: Novotny, Vojtech
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The phylogeny of plant hosts sampled in this study for geometrids or pyraloids.
Diffusive Exit Rates Through Pores in Membrane-Enclosed Structures
Creators: name: Yang, Zitao
name: Koslover, Elena F.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the channel. We propose a simple approximate model, validated with stochastic simulations, for estimating the effective release rate from cylinders, and other simple-shaped domains, as a function of channel parameters. The results demonstrate that, for very small pores, a low density of channels scattered over the boundary is sufficient to achieve substantial rates of particle release. Furthermore, we show that increasing the length of passive channels will both reduce release rates and lead to a less steep dependence on channel density. Our results are compared to previously-measured local calcium release rates from tubules of the endoplasmic reticulum, providing an estimate of the relevant channel density responsible for the observed calcium efflux.
Parametrized quantum circuit for weight-adjustable quantum loop gas
Creators: name: Sun, Rong-Yang
name: Shirakawa, Tomonori
name: Yunoki, Seiji
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Motivated by the recent success of realizing the topologically ordered ground state of the exactly solvable toric code model by a quantum circuit on the real quantum device [K. J. Satzinger {\it et al}., Science \textbf{374}, 1237 (2021)], here we propose a parametrized quantum circuit (PQC) with the same real-device-performable optimal structure to represent quantum loop gas states with adjustably weighted loop configurations. Combining such a PQC with the variational quantum eigensolver, we obtain the accurate quantum circuit representation for the toric code model in an external magnetic field with any field strength, where the system is not exactly solvable. The topological quantum phase transition in this system is further observed in the optimized circuits by measuring the magnetization and topological entanglement entropy.
description: 5 pages, 4 figures