cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hydrogen adsorption on Pt-decorated closed-end armchair (3,3), (4,4) and (5,5) single-walled carbon nanotubes
Creators: name: Charinee Kaewkhonkaen
name: Vithaya Ruangpornvisuti
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Structures of small lengths of capped (3,3), (4,4) and (5,5) single-walled carbon nanotubes (SWCNTs) and their structures decorated by Pt atom and Ptn clusters (n = 2–4) were obtained using density functional theory calculations. Binding abilities of Pt atom and Ptn clusters on the outer surface of SWCNTs at various adsorption sites were explored. Adsorptions of H2 onto Pt atom of the Pt-decorated (3,3), (4,4) and (5,5) SWCNTs were studied and their adsorption energies are reported. The thermodynamic properties and equilibrium constants for H2 adsorptions on the Pt4-decorated (3,3), (4,4) and (5,5) SWCNTs were obtained. The adsorption of H2 on the Pt atom of the Pt4/(3,3) SWCNT was found to be the most preferred reaction of which enthalpy and free energy changes at room temperature are −46.61 and −23.99 kcal/mol, respectively.
Modulation of MHC class I expression by African swine fever virus and the role of virus proteins EP153R and CD2v
Creators: name: Arav, Derah Saward
Publisher: name: figshare
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Molecular Biology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Various DNA viruses, including pox- and herpesviruses, express proteins which downregulate host MHC class I antigen expression as an immune evasion strategy. Previous studies into whether ASFV modulates expression of the porcine MHC class I molecule, SLA-I, have not provided a clear answer. In this thesis, the effect of African swine fever virus (ASFV) and the roles of two proteins, EP153R and CD2v, were investigated in the transcription, protein synthesis and expression of SLA-I at the surface of ASFV-infected cells. The expression and localisation of EP153R were also investigated.
Triple targeting of Auger emitters using octreotate conjugated to a DNA-binding ligand and a nuclear localizing signal
Creators: name: Violet, John A.
name: Farrugia, Gabriella
name: Skene, Colin
name: White, Jonathan
name: Lobachevsky, Pavel
name: Martin, Roger
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Purpose: We investigated the effect of incorporation of a nuclear localization signal (NLS) into a conjugate comprising the DNA binding ligand para-iodoHoechst (PIH) and octreotate on its DNA binding and affinity to the somatostatin receptor (SSTR). Confirmation of these properties would support development of similar conjugates labelled with Auger emitters for their potential in Auger endoradiotherapy. Materials and methods: We synthesized conjugates of PIH and octreotate (PO) or PIH and NLS (PN) and a conjugate comprising PIH, NLS and octreotate (PNO). DNA-binding characteristics of PIH and conjugates were assessed using synthetic DNA oligonucleotides employing spectrophotometric titration of ligand solutions with DNA. We used membranes from the type 2 SSTR (SSTR2) overexpressing human non-small cell lung cancer cell line A427-7 to investigate the binding affinity of PNO. Results: We demonstrated PN and PNO retain specific high affinity DNA-binding properties observed for PIH, and acquire an additional non-specific binding capacity. No DNA binding was observed for PO. PNO retains its binding affinity for SSTR. Conclusions: The DNA-binding properties of PNO and its affinity for SSTR suggests that it could potentially be used for tumour-specific delivery of PIH labelled with an Auger emitter in SSTR expressing tumours.
Static scanning tunneling microscopy images reveal the mechanism of supramolecular polymerization of an oligopyridineon graphite
Creators: name: Goll, Felix D.
name: Taubmann, Gerhard
name: Ziener, Ulrich
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Chain Growth Polymerization
subject: Oligopyridine
subject: DDC 540 / Chemistry & allied sciences
subject: Addition polymerization
subject: Reaction mechanisms (Chemistry)
subject: Scanning tunneling microscopy
subject: Self-assembly (Chemistry)
subject: Reaktionsmechanismus
subject: Rastertunnelmikroskopie
subject: Selbstorganisation

description: Supramolecular polymerization of a donor–acceptor bisterpyridine (BTP) equipped with an electron-rich carbazole unit is observed by scanning tunneling microscopy (STM) at the highly oriented pyrolytic graphite (HOPG)|solution interface. It is shown that two-dimensional crystals of supramolecular (co)polymers are formed by chain growth polymerization, which in turn can be described by copolymerization statistics. From concentration-dependent measurements, derived copolymerization parameters and DFT calculations, a mechanism for self-assembly is developed that suggests a kinetically driven polymerization process in combination with thermodynamically controlled crystallization.
Additional file 1 of Diagnostic utility of antigen detection rapid diagnostic tests for Covid-19: a systematic review and meta-analysis
Creators: name: Ghasemi, Somaye
name: Harmooshi, Narges Nazari
name: Rahim, Fakher
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1.
Thomas first Lord Wharton's parks at Ravenstonedale and Wharton.
Creators: name: Hoyle, R W
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 111-118
description: Documentary materials in support of recently discussed field evidence for the surviving deer park walls (see also 87/1950).
The hospital of St Nicholas, Carlisle and its masters; Part 1 - The period up to 1333.
Creators: name: Wiseman, W G
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 93-110
description: Historical/biographical account of the masters of the largest and best documented site of this type in the area, up to the early-fourteenth century.
Athelwold the Bishop and Walter the Priest: a new source for the early history of Carlisle Priory.
Creators: name: Summerson, Henry
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 85-92
description: Discusses the contribution of information from a transcript of a charter of Athelwold.
Trennfunktion für den stationären Siebprozess
Creators: name: Teipel, Ulrich
name: Wolf, Sebastian
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Siebklassierung
subject: Siebprozess
subject: Trenneffizienz
subject: Trennfunktion
subject: Grade efficiency
subject: Screen classification
subject: Screening process
subject: Separation efficiency
subject: DDC 540 / Chemistry & allied sciences
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Diskriminanzfunktion

description: Es wird eine neue Trennfunktion T(x, α′, β) für den stationären Siebprozesses vorgestellt. Sie ist eine Funktion der Partikelgröße x, der Trennschärfe α′ und der neue eingeführten Trenneffizienz β. Mit der neuen Trennfunktion kann der Siebklassierprozess sehr gut beschrieben werden, insb. im Fein- und Grobgutbereich ist eine sehr gute Übereinstimmung mit den Messwerten zu beobachten. Ein Vergleich der Trennfunktionen berechnet mit dem Trennschärfeparameter α′ und der Trenneffizienz β zu den Trennfunktionen, die nur mit α′ ermittelt wurden, zeigt, dass durch T(x, α′, β) eine wesentliche Verbesserung der Charakterisierung des stationären Siebklassierprozesses möglich ist. Das neue Modell der Trennfunktion T(x, α′, β) liefert eine wesentlich bessere Übereinstimmung mit den Messwerten als andere Modelle und ist somit zur Beschreibung einer Trennfunktion für den stationären Siebprozess sehr gut geeignet ist.
Additional file 2 of Diagnostic utility of antigen detection rapid diagnostic tests for Covid-19: a systematic review and meta-analysis
Creators: name: Ghasemi, Somaye
name: Harmooshi, Narges Nazari
name: Rahim, Fakher
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 2.
The ring ditch site above Middleton Hall, Cumbria: surface and resistivity surveys.
Creators: name: Woolliscroft, David J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 61-72
description: Reports survey on a site held to be a barrow but recently suggested, on morphological grounds, to represent a Roman signal or watch tower instead. It is thought that the survey evidence upholds the former interpretation, although there is the possibility of later, Roman, re-use of the site.
Simple and efficient synthesis of N-alkyl and N-aryl succinimides in hot water
Creators: name: Bozdoğan, Burcu
name: Erşatır, Mehmet
name: Demirkol, Onur
name: Akbaşlar, Dilek
name: E. Sultan Giray
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: A new, simple synthesis of succinimides is described. The reactions were carried out under the ultimate green conditions excluding both catalyst and organic solvent by applying simple stirring at 100 °C. A wide variety of N-susbstituted succinimides have been prepared in high yields by using succinic acid and primary amines in hot water. Yield of N-alkyl substituted succinimides were found to be higher than those of N-aryl substituted succinimides.
title: OFROM: interview avec unine15a87m
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.5ba9t1sl.v2#47532477b3a45e59e661df77ba735fa4ad829860
From Edge Computing to Edge Intelligence: exploring novel design approaches to intelligent IoT applications
Creators: name: Antonini, Mattia
Publisher: name: Universit� degli studi di Trento
Year: 2021

description: The Internet of Things (IoT) has deeply changed how we interact with our world. Today, smart homes, self-driving cars, connected industries, and wearables are just a few mainstream applications where IoT plays the role of enabling technology. When IoT became popular, Cloud Computing was already a mature technology able to deliver the computing resources necessary to execute heavy tasks (e.g., data analytic, storage, AI tasks, etc.) on data coming from IoT devices, thus practitioners started to design and implement their applications exploiting this approach. However, after a hype that lasted for a few years, cloud-centric approaches have started showing some of their main limitations when dealing with the connectivity of many devices with remote endpoints, like high latency, bandwidth usage, big data volumes, reliability, privacy, and so on. At the same time, a few new distributed computing paradigms emerged and gained attention. Among all, Edge Computing allows to shift the execution of applications at the edge of the network (a partition of the network physically close to data-sources) and provides improvement over the Cloud Computing paradigm. Its success has been fostered by new powerful embedded computing devices able to satisfy the everyday-increasing computing requirements of many IoT applications. Given this context, how can next-generation IoT applications take advantage of the opportunity offered by Edge Computing to shift the processing from the cloud toward the data sources and exploit everyday-more-powerful devices? This thesis provides the ingredients and the guidelines for practitioners to foster the migration from cloud-centric to novel distributed design approaches for IoT applications at the edge of the network, addressing the issues of the original approach. This requires the design of the processing pipeline of applications by considering the system requirements and constraints imposed by embedded devices. To make this process smoother, the transition is split into different steps starting with the off-loading of the processing (including the Artificial Intelligence algorithms) at the edge of the network, then the distribution of computation across multiple edge devices and even closer to data-sources based on system constraints, and, finally, the optimization of the processing pipeline and AI models to efficiently run on target IoT edge devices. Each step has been validated by delivering a real-world IoT application that fully exploits the novel approach. This paradigm shift leads the way toward the design of Edge Intelligence IoT applications that efficiently and reliably execute Artificial Intelligence models at the edge of the network.
Geometry of Language: Semantic Manifolds & Hyperspace By King Tut
Creators: name: King Tut
Publisher: name: Zenodo
Year: 2025

description: This paper explores the possibility that language operates within a semantic fractal-manifold, where meaning is mapped onto a high-dimensional geometric structure. By integrating Gematria transformations, modular arithmetic, and fractal analysis, we investigate whether linguistic relationships follow hidden mathematical patterns. We propose computational experiments to test these ideas, examining semantic attractors and numerical resonances in large text corpora. If language is inherently geometric, it may reveal deeper insights into AI, cognition, and the fundamental structure of reality
Additional file 3 of Diagnostic utility of antigen detection rapid diagnostic tests for Covid-19: a systematic review and meta-analysis
Creators: name: Ghasemi, Somaye
name: Harmooshi, Narges Nazari
name: Rahim, Fakher
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 3.
Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock
Creators: name: Chakraborty, Shinjini
name: Winkelmann, Veronika Eva
name: Braumüller, Sonja
name: Palmer, Annette
name: Schultze, Anke
name: Klohs, Bettina
name: Ignatius, Anita
name: Vater, Axel
name: Fauler, Michael
name: Frick, Manfred
name: Huber-Lang, Markus
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Diseases
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular medicine
subject: Physiology
subject: FOS: Biological sciences
subject: C5A ANAPHYLATOXIN RECEPTOR
subject: ALVEOLAR EPITHELIAL-CELLS
subject: COMPLEMENT ACTIVATION
subject: INNATE IMMUNITY
subject: ORGAN FAILURE
subject: II CELLS
subject: SURFACTANT
subject: PROTECTS
subject: DIFFERENTIATION
subject: DYSFUNCTION
subject: DDC 610 / Medicine & health

description: Abstract Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses. However, the role of inhibiting C5a has not been evaluated in the context of sterile systemic inflammatory responses, like polytrauma and hemorrhagic shock (PT + HS). In our presented study, a novel and highly specific C5a L-aptamer, NoxD21, was used to block C5a activity in an experimental murine model of PT + HS. The aim of the study was to assess early modulation of inflammatory responses and lung damage 4 h after PT + HS induction. NoxD21-treated PT + HS mice displayed greater polymorphonuclear cell recruitment in the lung, increased pro-inflammatory cytokine levels in the bronchoalveolar lavage fluids (BALF) and reduced myeloperoxidase levels within the lung tissue. An in vitro model of the alveolar-capillary barrier was established to confirm these in vivo observations. Treatment with a polytrauma cocktail induced barrier damage only after 16 h, and NoxD21 treatment in vitro did not rescue this effect. Furthermore, to test the exact role of both the cognate receptors of C5a (C5aR1 and C5aR2), experimental PT + HS was induced in C5aR1 knockout (C5aR1 KO) and C5aR2 KO mice. Following 4 h of PT + HS, C5aR2 KO mice had significantly reduced IL-6 and IL-17 levels in the BALF without significant lung damage, and both, C5aR1 KO and C5aR2 KO PT + HS animals displayed reduced MPO levels within the lungs. In conclusion, the C5aR2 could be a putative driver of early local inflammatory responses in the lung after PT + HS.
Regioselective N(2)-H-functionalization of thiosemicarbazones of aromatic and heteroaromatic aldehydes with acrylonitrile
Creators: name: Mal’kina, Anastasiya G.
name: Nosyreva, Valentina V.
name: Albanov, Alexander I.
name: Afonin, Andrei V.
name: Vashchenko, Alexander V.
name: Amosova, Svetlana V.
name: Trofimov, Boris A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Regioselective N(2)-H-cyanoethylation of thiosemicarbazones of aromatic and heteroaromatic aldehydes with acrylonitrile proceeds under mild conditions (14% KOH, acetone/H2O, 35 °C, 6–21 h) to afford 1-(2-сyanoethyl)-2-[(E)-aryl(heteroaryl)methylidene]-1-hydrazinecarbothioamides in up to 74% yields. The synthesized thioamides are promising precursors of novel families of functionalized thiosemicarbazones as exemplified by hydrolysis of their cyano group to the corresponding amido function (46.5–60% yields).
The Late Devensian Climate around Morecambe Bay.
Creators: name: Williamson, Iain A
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 277-278
description: A consideration of evidence for the palaeoclimate in this region leads to the conclusion that it was probably ice-free and therefore possibly occupied.
Simple generalized reaction conditions for the conversion of primary aliphatic amines to surfactant-like guanidine salts with 1H-pyrazole carboxamidine hydrochloride
Creators: name: T. A. Bakka
name: O. R. Gautun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Improved reaction conditions for the electrophilic reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with, were obtained in decent yields with short reaction times, minimal workup, and high level of purity.
Exploring how Syrian women manage their health after migration to Germany: results of a qualitative study
Creators: name: Kikhia, Salma
name: Gharib, Ghaith
name: Sauter, Alexandra
name: Vincens, Natalia Caldeira Loss
name: Loss, Julika
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Syrian women
subject: Immigrant health
subject: Germany
subject: Access to healthcare
subject: Post-migration stress
subject: Resilience
subject: DDC 610 / Medicine & health

description: Abstract Background In the recent years, the number of Syrians living in Germany increased drastically due to the massive displacement caused by the Syrian conflict. Syrian migrant women in Germany are challenged by both the migration process and the changing of social roles. Seeking out healthcare may be hampered by linguistic and cultural barriers, but the new context may offer opportunities for health and well-being (free access to health care, civil/human rights). Little is known about how Syrian women manage their health after their resettlement in Germany. Methods In depth interviews in Arabic were conducted with 9 Syrian women who were recruited through purposive sampling (18–55 years, migrated in 2011–2017, different education levels), focusing on capabilities to control one’s health and to navigate the German healthcare system, and social/environmental barriers and facilitators to effectively manage their health. Interview transcripts were analysed using qualitative content analysis. Results The women reported their health to be impaired by post-migration stressors, such as perceived discrimination, loss of social status and worrying about the future. Many interviewees felt disempowered and incompetent to successfully and actively navigate the German healthcare system, lacking information and not understanding their rights and options under the health insurance plan. The language barrier added to feeling vulnerable. Many women experienced doctors declining to treat them for capacity reasons; when treated, they often did not feel taken seriously or were dissatisfied with the emotional/cultural aspects of care. If possible, Arabic doctors were sought out. Some women, however, described improved resources for health, and appreciated better women’s rights as a source of power. Conclusions The lack of information about the structure and offers of the German healthcare system, language and culture specific barriers as well as socio-cultural challenges are undermining the ability of Syrian women to manage their health effectively after their resettlement in Germany. Providing tailored information on the German healthcare system, creating a health-literacy supportive environment, and improving cultural sensitivity in healthcare provision could help Syrian women better utilize medical care offered in Germany.
Regioselective N(2)-H-Functionalization of Thiosemicarbazones of Aromatic and Heteroaromatic Aldehydes with Acrylonitrile
Creators: name: Mal'kina, Anastasiya G.
name: Nosyreva, Valentina V.
name: Albanov, Alexander I.
name: Afonin, Andrei V.
name: Vashchenko, Alexander V.
name: Amosova, Svetlana V.
name: Trofimov, Boris A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Regioselective N(2)-H-cyanoethylation of thiosemicarbazones of aromatic and heteroaromatic aldehydes with acrylonitrile proceeds under mild conditions (14% KOH, acetone/H2O, 35 °C, 6-21 h) to afford 1-(2-сyanoethyl)-2-[(Е)-aryl(heteroaryl)methylidene]-1-hydrazinecarbothioamides in up to 74% yields. The synthesized thioamides are promising precursors of novel families of functionalized thiosemicarbazones as exemplified by hydrolysis of their cyano group to the corresponding amido function (46.5-60% yields).
Advantages and disadvantages of (dedicated) model transformation languages
Creators: name: Höppner, Stefan
name: Haas, Yves
name: Tichy, Matthias
name: Juhnke, Katharina
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Interview Study
subject: Model Transformation Language
subject: DSL
subject: Model Transformation
subject: MDSE
subject: advantages
subject: disadvantages
subject: Qualitative Analysis
subject: DDC 004 / Data processing & computer science
subject: DDC 620 / Engineering & allied operations
subject: Computer software; Development
subject: Software engineering
subject: Programming languages (Electronic computers)
subject: Model-driven software architecture
subject: Qualitative research
subject: Interviewing
subject: Softwareentwicklung
subject: Modellgetriebene Entwicklung
subject: Modelltransformation
subject: Qualitative Analyse
subject: Interview

description: Context Model driven development envisages the use of model transformations to evolve models. Model transformation languages, developed for this task, are touted with many benefits over general purpose programming languages. However, a large number of these claims have not yet been substantiated. They are also made without the context necessary to be able to critically assess their merit or built meaningful empirical studies around them. Objective The objective of our work is to elicit the reasoning, influences and background knowledge that lead people to assume benefits or drawbacks of model transformation languages. Method We conducted a large-scale interview study involving 56 participants from research and industry. Interviewees were presented with claims about model transformation languages and were asked to provide reasons for their assessment thereof. We qualitatively analysed the responses to find factors that influence the properties of model transformation languages as well as explanations as to how exactly they do so. Results Our interviews show, that general purpose expressiveness of GPLs, domain specific capabilities of MTLs as well as tooling all have strong influences on how people view properties of model transformation languages. Moreover, the Choice of MTL, the Use Case for which a transformation should be developed as well as the Skill s of involved stakeholders have a moderating effect on the influences, by changing the context to consider. Conclusion There is a broad body of experience, that suggests positive and negative influences for properties of MTLs. Our data suggests, that much needs to be done in order to convey the viability of model transformation languages. Efforts to provide more empirical substance need to be undergone and lacklustre language capabilities and tooling need to be improved upon. We suggest several approaches for this that can be based on the results of the presented study.
A Linked Data Model for Entity Aggregation
Creators: name: Richard, Wallis
Publisher: name: Dublin Core Metadata Initiative
Year: 2024

description: A fundamental requirement for the development of the Linked Data Knowledge Graph at the National Library Board of Singapore (NLB) was to able to ingest multiple entity descriptions, for the same real world object. Imagine all the individual Person entities for a prolific author that would be created if you import all the MARC records from a library management system.To satisfy this requirement an adaptive data model was developed utilising elements of the OAI-ORE Aggregation vocabulary to track the relationship between individual source derived entities (for the same object) and a primary entity which exhibits a consolidated view across all the sources.Richard will describe this simple model that is capable of dynamically tracking relationships even when source entities are deleted, modified, or added to the knowledge graph.
Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)
Creators: name: Rothe, Kathrin
name: Spinner, Christoph D.
name: Panning, Marcus
name: Pletz, Mathias W.
name: Rohde, Gernot
name: Rupp, Jan
name: Witzenrath, Martin
name: Erber, Johanna
name: Eberhardt, Frank
name: Essig, Andreas
name: Schneider, Jochen
name: CAPNETZ Study Grp
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: COVID-19
subject: Community-acquired co-infection
subject: Bacterial pathogens
subject: Rapid multiplex PCR diagnostic
subject: Antibiotic stewardship
subject: DDC 610 / Medicine & health

description: Abstract Purpose Thorough knowledge of the nature and frequency of co-infections is essential to optimize treatment strategies and risk assessment in cases of coronavirus disease 2019 (COVID-19). This study aimed to evaluate the multiplex polymerase chain reaction (PCR) screening approach for community-acquired bacterial pathogens (CABPs) at hospital admission, which could facilitate identification of bacterial co-infections in hospitalized COVID-19 patients. Methods Clinical data and biomaterials from 200 hospitalized COVID-19 patients from the observational cohort of the Competence Network for community-acquired pneumonia (CAPNETZ) prospectively recruited between March 17, 2020, and March 12, 2021 in 12 centers in Germany and Switzerland, were included in this study. Nasopharyngeal swab samples were analyzed on hospital admission using multiplex real-time reverse transcription (RT)-PCR for a broad range of CABPs. Results In total of 200 patients Staphylococcus aureus (27.0%), Haemophilus influenzae (13.5%), Streptococcus pneumoniae (5.5%), Moraxella catarrhalis (2.5%), and Legionella pneumophila (1.5%) were the most frequently detected bacterial pathogens. PCR detection of bacterial pathogens correlated with purulent sputum, and showed no correlation with ICU admission, mortality, and inflammation markers. Although patients who received antimicrobial treatment were more often admitted to the ICU and had a higher mortality rate, PCR pathogen detection was not significantly related to antimicrobial treatment. Conclusion General CABP screening using multiplex PCR with nasopharyngeal swabs may not facilitate prediction or identification of bacterial co-infections in the early phase of COVID-19-related hospitalization. Most patients with positive PCR results appear to be colonized rather than infected at that time, questioning the value of routine antibiotic treatment on admission in COVID-19 patients.
Simple Generalized Reaction Conditions for the Conversion of Primary Aliphatic Amines to Surfactant-Like Guanidine Salts with 1H-Pyrazole Carboxamidine Hydrochloride
Creators: name: T. A. Bakka
name: O. R. Gautun
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Improved reaction conditions for the electrophilic reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The often hard to work with surfactant-like guanidine salts were obtained in decent yields with short reaction times, minimal work up and high level of purity.
Culturally adapting internet- and mobile-based health promotion interventions might not be worth the effort: a systematic review and meta-analysis
Creators: name: Balci, Sumeyye
name: Spanhel, Kerstin
name: Bosse Sander, Lasse
name: Baumeister, Harald
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Human behaviour
subject: Psychology
subject: FOS: Psychology
subject: Science in culture
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Public health
subject: Health promotion
subject: Telemedicine
subject: Gesundheitsförderung
subject: Telemedizin
subject: Metaanalyse

description: Health promotion interventions offer great potential in advocating a healthy lifestyle and the prevention of diseases. Some barriers to communicating health promotion to people of certain cultural groups might be overcome via the internet- and mobile-based interventions (IMI). This systematic review and meta-analysis aims to explore the effectiveness of culturally adapted IMI for health promotion interventions among culturally diverse populations. We systematically searched on Cochrane Central Register of Controlled Trials (CENTRAL), EbscoHost/MEDLINE, Ovid/Embase, EbscoHost/PsychINFO, and Web of Science databases in October 2020. Out of 9438 records, 13 randomized controlled trials (RCT) investigating culturally adapted health promotion IMI addressing healthy eating, physical activity, alcohol consumption, sexual health behavior, and smoking cessation included. From the included studies 10,747 participants were eligible. Culturally adapted IMI proved to be non-superior over active control conditions in short- (g = 0.10, [95% CI −0.19 to 0.40]) and long-term (g = 0.20, [95% CI −0.11 to 0.51]) in promoting health behavior. However, culturally adapted IMI for physical activity (k = 3, N = 296) compared to active controls yielded a beneficial effect in long-term (g = 0.48, [95%CI 0.25 to 0.71]). Adapting health promotion IMI to the cultural context of different cultural populations seems not yet to be recommendable given the substantial adaption efforts necessary and the mostly non-significant findings. However, these findings need to be seen as preliminary given the limited number of included trials with varying methodological rigor and the partly substantial between-trial heterogeneity pointing in the direction of potentially useful culturally adapted IMI which now need to be disentangled from the less promising approaches.
Copper-catalyzed domino cyclization of propargylic alcohol with tosyl isocyanate to oxazolidinones
Creators: name: Xiu-Shuai Chen
name: Chuan-Jin Hou
name: Liu, Yan-Jun
name: Yang, Rui-Feng
name: Hu, Xiang-Ping
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A copper-catalyzed domino cyclization of propargylic alcohols with tosyl isocyanate for the synthesis of oxazolidinones has been developed. Various propargylic alcohols with an aryl or alkyl substituents worked smoothly to afford the corresponding oxazolidinones in moderate to excellent yields.
Additional file 1 of TE Density: a tool to investigate the biology of transposable elements
Creators: name: Teresi, Scott J.
name: Teresi, Michael B.
name: Edger, Patrick P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 Supplementary figures and table.
Copper catalyzed domino cyclization of propargylic alcohol with tosyl isocyanate to oxazolidinones
Creators: name: Xiu-Shuai Chen
name: Chuan-Jin Hou
name: Liu, Yan-Jun
name: Yang, Rui-Feng
name: Hu, Xiang-Ping
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A copper catalyzed domino cyclization of propargylic alcohols with tosyl isocyanate for the synthesis of oxazolidinones has been developed. Various propargylic alcohols with an aryl or alkyl substituent worked smoothly to afford the corresponding oxazolidinones in moderate to excellent yields.
Molecular donor‐acceptor dyads for single‐material organic solar cells
Creators: name: Aubele, Anna
name: Kraus, Teresa
name: Schmid, Sylvia
name: Mena‐Osteritz, Elena
name: Bäuerle, Peter
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Donor-acceptor dyad
subject: Optoelectronic properties
subject: Single material organic solar cells
subject: Structure-property relationships
subject: DDC 540 / Chemistry & allied sciences
subject: Optoelectronics
subject: Fullerene

description: A series of ambipolar covalently linked oligothiophene-fullerene dyads have been synthesized by systematical structural variations. In this respect, the length of linker between donor and acceptor unit was altered and in a second series the terminal acceptor units in the donor unit of the dyads were varied. Characterization of the optical and redox properties gave valuable structure-property relationships and were correlated to the photovoltaic performance in single-material organic solar cells, in which power conversion efficiencies of up to 4.3 % were reached.
Viral interference of the bacterial RNA metabolism machinery
Creators: name: Dendooven, Tom
name: Bossche, An Van Den
name: Hendrix, Hanne
name: Pieter-Jan Ceyssens
name: Voet, Marleen
name: K. J. Bandyra
name: Maeyer, Marc De
name: Aertsen, Abram
name: Noben, Jean-Paul
name: Hardwick, Steven W.
name: Luisi, Ben F.
name: Lavigne, Rob
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: In a recent publication, we reported a unique interaction between a protein encoded by the giant myovirus phiKZ and the Pseudomonas aeruginosa RNA degradosome. Crystallography, site-directed mutagenesis and interactomics approaches revealed this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack 2 conserved RNA binding sites on the scaffold domain of the RNase E component of the RNA degradosome. This interaction prevents substrate RNAs from being bound and degraded by the RNA degradosome during the virus infection cycle. In this commentary, we provide a perspective into the biological role of Dip, its structural analysis and its mysterious evolutionary origin, and we suggest some therapeutic and biotechnological applications of this distinctive viral protein.
THEORETICAL BASICS IN STUDYING THE PROBLEM OF AGGRESSION
Creators: name: Tojiboyeva, Gulkhumor
name: Israilov, Akromjon
Publisher: name: Zenodo
Year: 2024

description: This article covers the researches of eastern thinkers and western psychology aimed at studying the problem of aggression, which is one of the manifestations of behavioral deviation that occurs during adolescence. Basically, in our article, a number of thoughts, ideas and theories aimed at studying the problem of aggression have been adequately discussed.
Additional file 1 of Epidural analgesia information sessions provided by anesthetic nurses: impact on satisfaction and anxiety of parturient women a prospective sequential study
Creators: name: Cherel, Quentin
name: Burey, Julien
name: Rousset, Julien
name: Picard, Anne
name: Mirza, Dimitra
name: Dias, Christina
name: Jacquet, Hélène
name: Mariani, Paule
name: Raffegeau, Nathalie
name: Saupin, Isabelle
name: Bornes, Marie
name: Lapidus, Nathanaël
name: Quesnel, Christophe
name: Garnier, Marc
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1. STROBE Statement—checklist of items that should be included in reports of observational studies
Effectiveness, acceptability, and mechanisms of change of the internet-based intervention studicare mindfulness for college students : a randomized controlled trial
Creators: name: Küchler, Ann-Marie
name: Kählke, Fanny
name: Vollbrecht, Danielle
name: Peip, Katharina
name: Ebert, David D.
name: Baumeister, Harald
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: College students
subject: Internet- and mobile-based intervention
subject: Mechanisms of change
subject: DDC 150 / Psychology
subject: Mindfulness
subject: Acceptance and commitment therapy
subject: Students; Psychology
subject: Crisis intervention
subject: Telemedicine
subject: Medical informatics applications
subject: Randomized controlled trial
subject: Student
subject: Akzeptanz- und Commitment Therapie
subject: Krisenintervention
subject: Telemedizin
subject: E-Health
subject: Achtsamkeit

description: Objectives College is an exhilarating but stressful time often associated with mental distress. The StudiCare project offers Internet- and mobile-based interventions (IMI) for college student mental health promotion. Within this framework, we evaluated the IMI StudiCare Mindfulness, and examined potential moderators and mediators of effectiveness. Methods In this randomized controlled trial, 150 college students with low to moderate mindfulness were randomly assigned to StudiCare Mindfulness or a waitlist control group (WL). StudiCare Mindfulness comprises 5 weekly online modules based on Acceptance Commitment Therapy and stress management. Assessments took place before (t0) and 6 weeks after (t1) randomization. Primary outcome was mindfulness. Secondary outcomes were stress, depression, anxiety, quality of life, intervention satisfaction, and adherence. Sociodemographic variables, pre-intervention symptomatology, personality traits, and attitudes towards IMI were examined as potential moderators. Results Intention-to-treat analyses (N = 149) showed a large effect of StudiCare Mindfulness on mindfulness (d = 1.37; 95% CI: 1.01–1.73) compared to WL at t1 (β = 1.18; 95% CI: 0.96–1.40). Effects on secondary outcomes were significant in favor of the intervention group except for physical quality of life. Mindfulness was found to mediate intervention effectiveness on depression, anxiety, and stress. Moderation analysis was non-significant except for baseline openness to experience, with lower openness associated with larger intervention effects on mindfulness. Conclusions This trial suggests that StudiCare Mindfulness may enhance mindfulness and reduce mental health problems. Its potential applicability as low-threshold prevention and treatment option on a population level should be subject to future trials. Trial Registration German Clinical Studies Trial Register TRN: DRKS00012559.
Impact of a child’s cancer disease on parents’ everyday life: a longitudinal study from Sweden
Creators: name: Hovén, Emma
name: Grönqvist, Helena
name: Pöder, Ulrika
name: Essen, Louise Von
name: Norberg, Annika Lindahl
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Background: A child’s cancer disease may disrupt the daily life of the affected family for a long period. The aim was to describe restrictions on parents’ leisure activities and work/studies during and after the child’s treatment. Methods: This study used data from a cohort of mothers and fathers (n = 246) of children diagnosed with cancer. Data was collected five times from two months after diagnosis to one year after end of treatment. Reports of restrictions were evaluated over time, between mothers and fathers, and in relation to parent-reported child symptom burden (The Memorial Symptom Assessment Scale) and partial post-traumatic stress disorder (PTSD) (The PTSD Checklist-Civilian Version). Results: Two (51%) and four (45%) months after diagnosis, about half reported that their leisure activities were restricted at least some of the time. Corresponding percentages for restrictions on work/studies were 84% and 77%. One year after end of treatment, the great majority reported that their leisure activities (91%) and/or work/studies (76%) were never/seldom restricted. During treatment, more mothers than fathers reported restrictions on work/studies all/most of the time. After end of treatment, gender was only related to reports of restrictions among parents not reporting partial PTSD. More parents who reported being restricted all/most of the time also reported partial PTSD and/or a greater symptom burden for the child. Conclusion: Parents report frequent restrictions on everyday life during treatment. One year after end of treatment, parents report only a limited impact of the child’s cancer on their leisure activities and work/studies. More parents who report restrictions also report partial PTSD and/or a greater child symptom burden. The effect of gender on restrictions varies depending on reports of partial PTSD. Future studies of gender differences regarding the impact of a child’s cancer on parents’ everyday life should thus consider mothers’ and fathers’ level of psychological distress.
Lead mines in the manor of Kinniside.
Creators: name: Banks, T M
name: Nichol, C
name: Bridge, D G G
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 215-248
description: A paper drawing together extant, predominantly documentary, information on the development of the mines from the late eighteenth century to the mid-nineteenth century. There is an `Appendix: the death of James Francis' (239--40).