title: ÐÐ°ÑÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð² ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¿Ð»Ð°ÑÑÐ¸ÑÐ½Ð¾ÑÑÐ¸ Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ðµ ÐºÑÑÑ, Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÐµ ÑÐµÐ±ÑÐ¸Ð»ÑÐ½ÑÐ¼Ð¸ ÑÑÐ´Ð¾ÑÐ¾Ð³Ð°Ð¼Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Disorders of synaptic plasticity mechanisms in the rat hippocampus caused by febrile seizures
Creators: name: ÐÑÐ¸ÑÐ»ÑÐº, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐµÐ¹ÑÐ¾Ð½Ñ
ÑÐµÐ±ÑÐ¸Ð»ÑÐ½ÑÐµ ÑÑÐ´Ð¾ÑÐ¾Ð³Ð¸
Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿
Ð´Ð¾Ð»Ð³Ð¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð°Ñ ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°ÑÐ¸Ñ
NMDA-ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ
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description: The given work is devoted to the study of the features of long-term synaptic potentiation (LTP) and short-term synaptic potentiation (STP) formation and the analysis of morphological changes in the hippocampus of rats of different ages after febrile seizures (FS) at the age of 10 days. The following tasks were being set: 1. To evaluate morphological changes in the hippocampal regions CA1, CA3, hilus and dentate gyrus of rats of different ages (12 days, 21-23 days, and 51-55 days) after FS at the age of 10 days; 2. To study the features of LTP formation in the hippocampal CA1 field of rats of different ages (21-23 days and 51-55 days) after FS at the age of 10 days; 3. To evaluate the role of NMDARs in the induction of LTP in the hippocampal CA1 field of rats of different ages (21-23 days and 51-55 days) after FS at the age of 10 days; 4. To study the effect of the NMDAR D-serine coagonist in the level of LTP in the hippocampal CA1 field of rats of different ages (21-23 days and 51-55 days) after FS at the age of 10 days; 5. To study the features of STP formation in the hippocampal CA1 field of rats of different ages (21-23 days and 51-55 days) after FS at the age of 10 days. The work was fulfilled on the premises of the laboratory of molecular mechanisms of neuronal interactions, Sechenov Institute of evolutionary physiology and biochemistry RAS. The study was performed on male Wistar rats. Histological studies included staining hippocampal slices by the Nissl method, electrophysiological studies included the method of induction and registration of LTP, and the method of paired stimulation for the study of STP in the hippocampal CA1 field. As a result, it was found that prolonged FS leads, firstly, to a decrease in the number of neurons in different hippocampal regions, and secondly, to long-term violations of the production of LTP, which can be caused by violations of interactions between neurons and glial cells. There is also a lack of influence of the FS on STP.