cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Heritable and environmental determinants of platelet response to acetylsalicylic acid/
Creators: name: Maree, Andrew
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Consistent levels of platelet inhibition are required to deliver effective antiplatelet therapy. Growing awareness that not all individuals respond comparably to aspirin has led to the concept of aspirin ‘resistance’ and prompted search for an means to confirm individual response. However, the term is misleading because there are many determinants of failure to respond to treatment. Aspirin’s primary pharmacological effect and that which is understood to prevent thrombosis is almost complete inactivation of platelet cyclooxygenase-1 and thereby inhibition of thromboxane biosynthesis. In this thesis I report findings from a study of patients with cardiovascular disease taking aspirin, in which I apply point-of-care and laboratory assays with varying specificity for cyclooxygenase inhibition. I demonstrate weak correlation between aspirin assays, some of which measure cyclooxygenase inhibition and others that detect platelet reactivity despite cyclooxygenase inactivation. I identify supernatant thromboxane generation as a sensitive assay of aspirin response. I also demonstrate that low dose enteric-coated aspirin preparations fail to deliver an adequate dose to many patients. Heritable factors determine platelet reactivity to a greater extent that environmental factors and largely determine residual activity in the presence of cyclooxygenase inhibition. I demonstrate that haplotypic variation in the cyclooxygenase-1 gene and a common splice variant in the gene that encodes the serotonin transporter modulate COX inhibition. I also identify a platelet G-protein (33 subunit splice variant that influences epinephrine-induced platelet activation via a non-COX dependent pathway. I demonstrate that the same variant increased bleeding in patients treated with the oral glycoprotein Ilb/IIIa antagonist orbofiban in the OPUS-TIMI 16 trial. Lastly I investigate the role of human growth arrest specific gene 6 in platelets. I take a molecular biology and in-silico analysis approach to characterising the gene and its transcriptional response elements. I also screen for genetic variants in its regulatory regions to assess their role in determining platelet reactivity.
Bayesian regional flood frequency analysis for large catchments
Creators: name: Thorarinsdottir, Thordis L.
name: Hellton, Kristoffer H.
name: Steinbakk, Gunnhildur H.
name: Schlichting, Lena
name: Engeland, Kolbjørn
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Regional flood frequency analysis is commonly applied in situations where there exists insufficient data at a location for a reliable estimation of flood quantiles. We develop a Bayesian hierarchical modeling framework for a regional analysis of data from 203 large catchments in Norway with the generalized extreme value (GEV) distribution as the underlying model. Generalized linear models on the parameters of the GEV distribution are able to incorporate location-specific geographic and meteorological information and thereby accommodate these effects on the flood quantiles. A Bayesian model averaging component additionally assesses model uncertainty in the effect of the proposed covariates. The resulting regional model is seen to give substantially better predictive performance than the regional model currently used in Norway.
"Beyond the Arrow" A Philosophical Primer on "Reversible Causality and Multidimensional Time"
Creators: name: Hussein, Salah
Publisher: name: Zenodo
Year: 2025
Subjects: Reversible causality
Dimensional time
Philosophy of physics
Temporal symmetry
Observer frame
Measurement philosophy
Scientific epistemology
Thought experiments

description: This work presents a philosophical exploration of causality and temporal structure in theoretical physics. It questions the traditional assumption that cause precedes effect in a one-directional, linear time structure, and proposes that time itself may possess multiple dimensions.

Drawing insights from relativity, observer-dependent frames, and the historical evolution of measurement tools, this thought experiment invites reconsideration of how our scientific frameworks reflect human cognitive and instrumental constraints rather than objective metaphysics.

This manuscript is currently under editorial consideration at Foundations of Physics (Springer).

License: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).
The Estimation Lie Algebra Associated with Quantum Filters
Creators: name: Amini, N. H.
name: Gough, J. E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Optimization and Control (math.OC)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We introduce the Lie algebra of super-operators associated with a quantum filter, specifically emerging from the Stratonovich calculus. In classical filtering, the analogue algebra leads to a geometric theory of nonlinear filtering which leads to well-known results by Brockett and by Mitter characterizing potential models where the curse-of-dimensionality may be avoided, and finite dimensional filters obtained. We discuss the quantum analogue to these results. In particular, we see that, in the case where all outputs are subjected to homodyne measurement, the Lie algebra of super-operators is isomorphic to a Lie algebra of system operators from which one may approach the question of the existence of finite-dimensional filters.
Post-Gaussian Varioational Method for the Nonlinear Schrodinger Equation
Creators: name: Cooper, F.
name: Shepard, H.
name: Lucheroni, C
name: Sodano, P.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Gaussians to study soliton behavior and blowup in the nonlinear Schrodinger equation in arbitrary dimension d and with arbitrary nonlinearity parameter kappa
description: 12pages Latex (figures available on request)
MOESM1 of Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae
Creators: name: Vanegas, Katherina
name: ArĂŠsu Larsen
name: Eichenberger, Michael
name: Fischer, David
name: Mortensen, Uffe
name: Naesby, Michael
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 1: Figure S1. De novo naringenin pathway in S. cerevisiae derived from phenylalanine and three malonyl-CoA. Figure S2. Host modifications in the naringenin strain. Figure S3. One-step in vivo assembly using Homologous Recombination Technology (HRT) in S. cerevisiae. Figure S4. Quantification of vitexin and isovitexin. Table S1. Synthetic and codon optimized genes, used in this study. Table S2. Main plasmids used in this study. Table S3. Indirect biosynthetic pathway. Table S4. Additional intermediates of the indirect biosynthetic pathway. Table S5. Direct biosynthetic pathway.
Global cognition, executive function, and metacognition in a stroke population
Creators: name: Banna, Mona Al
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Post-stroke cognitive impairment is associated with poor long-term outcomes and increased functional dependency. The overall study aim was to explore the relationships between global cognition, executive function and metacognition in a stroke population, to examine correlates and potential predictors of cognitive impairment and to determine the relationship between cognitive impairment and stroke in a Bahraini stroke sample in comparison to an age- and sex- matched control group. A sample of 130 stroke patients (case group) were recruited from the largest medical complex in Bahrain and 55 control participants from the non-stroke general population were recruited from two primary local health centres in the country. General demographic data, clinical assessment and neuropsychological battery of cognitive assessments was conducted on participants. The study found that individuals not affected by stroke have proportional risk factors to a stroke population in Bahrain. Approximately 48% of the stroke sample group had some degree of cognitive impairment with greater stroke severity being more significantly associated with worse overall cognitive impairment. Poorer performance on global cognition was correlated with executive dysfunction and more functional dependency. Stroke patients with higher levels of cognitive impairment were more likely to report lower cognitive self-consciousness levels, indicating an impairment in their metacognitive thought processes. Similarly, participants who performed poorly in the memory components of cognitive testing tended to subjectively report higher confidence in their memory skills, indicating an impairment in metamemory. Though no significant correlations were reported between total Metacognitive Questionnaire-30 scores and executive function and global cognition, the Metacognitive Questionnaire-30 was shown to be a good predictor of anxiety and depression post-stroke. The development of a tool that can consolidate both subjective and global objective assessment and thereby measure the full breadth of metacognitive function is necessary and may have important implications for future rehabilitation.
Additional file 1: of Associations between post-operative rehabilitation of hip fracture and outcomes: national database analysis (90 characters)
Creators: name: Su, Bowen
name: Newson, Roger
name: Soljak, Harry
name: Soljak, Michael
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Table S1. Mobility variables translation matrix. Table S2. construction of admission/discharge destination outcome variable. Figure S1. Flowchart of mobility and discharge destination models. Table S3 all baseline characteristics of mobility outcome population (both complete and incomplete cases) before data translation. Table S4. Frequency of mobility categories before and after data translation. Table S5. all baseline characteristics of Mobility Model population after data translation, complete cases only. Table S6. Strength of association between patient characteristics used in the Mobility models and mobility 30 days after discharge. Figure S2 unadjusted and adjusted difference in average treatment effect (ATE) of no mobilisation (=no) or mobilisation (=yes) on day/day after surgery for 30-day mobility outcome. Table S7 baseline characteristics of the discharge destination model. Figure S3 chart of confounder categories vs Somers’ D score for two category mobility outcome. Figure S4. Somers’ D of propensity score and component covariates with respect to: mobilisation = No. Figure S5. Somers’ D of propensity score and component covariates with respect to: mobilisation==No. (DOCX 1030 kb)
The Characterisation of FcγRIIa Antagonists
Creators: name: Arkins, Leah
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Increasing evidence for FcγRIIa as a key participant in the pathogenesis of autoimmune inflammatory disorders like rheumatoid arthritis and systemic lupus erythematosus marks this cell surface receptor as a potential target for treatment. The direct blockade of the FcγRIIa-IgG interaction in the prevention of platelet activation and inevitable inflammation with the use of novel inhibitors is a strategy that has been gaining interest. The discovery of mAbs and small molecules to inhibit the FcγRIIa in the treatment of immune complex-mediated inflammatory diseases has shown auspicious results. The FcγRIIa is the only Fc receptor expressed on platelets. Small molecule inhibitors synthesised in RCSI and clinically approved drugs have previously demonstrated inhibition in the binding of platelets to immobilised IgG and the aggregation of platelets induced by heat-agglutinated IgG. It is necessary to characterise the effect of these compounds on platelets and their specificity for the FcγRIIa in order for a lead compound to be selected. Characterisation and specificity tests were carried out in this study with FcγRIIa and the compounds. Significant binding of the compound MT-84 to FcγRIIa in a thermal shift assay was detected at a concentration of 10μM. At 50 μM, MT-84 demonstrated its potential to induce possible conformational changes to the FcγRIIa structure in both a thermal shift assay and in an ELISA. The compound MT-222 significantly inhibited the binding of FcγRIIa to IgG in an ELISA. In silico docking of the compounds into the crystal structures of the FcγRs suggests that these compounds are non-specific for the FcγRIIa. It was demonstrated that vinorelbine significantly induced partial activation of platelets and the loss of single platelets suggesting that vinorelbine induces thrombocytopenia through the FcγRIIa. This work suggests a direct interaction between MT-84 and MT-222 with the FcγRIIa. These compounds inhibit IgG mediated aggregation and adhesion, without the partial agonism seen with vinorelbine. Future work should focus on further characterisation of the interaction using more sensitive techniques such as surface plasmon resonance and isothermal titration calorimetry.
Building a linear equation of state for trapped gravitons from finite size effects and the Schwarzschild black hole case
Creators: name: Viaggiu, Stefano
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we continue the investigations present in \cite{1} and \cite{2} concerning the spectrum of trapped gravitons in a spherical box, and in particular inside a Schwarzschild black hole (BH). We explore the possibility that, due to finite size effects, the frequency of the radiation made of trapped gravitons can be modified in such a way that a linear equation of state $PV=γU$ for the pressure $P$ and the internal energy $U$ arises. Firstly, we study the case with $U\sim R$, where only fluids with $γ>-\frac{1}{3}$ are possible. If corrections $\sim 1/R$ are added to $U$, for $γ\in[0,\frac{1}{3}]$ we found no limitation on the allowed value for the areal radius of the trapped sphere $R$. Moreover, for $γ>\frac{1}{3}$ we have a minimum allowed value for $R$ of the order of the Planck length $L_P$. Conversely, a fluid with $P<0$ can be obtained but with a maximum allowed value for $R$. With the added term looking like $\sim 1/R$ to the BH internal energy $U$, the well known logarithmic corrections to the BH entropy naturally emerge for any linear equation of state. The results of this paper suggest that finite size effects could modify the structure of graviton's radiation inside, showing a possible mechanism to transform radiation into dark energy.
description: Final version published in Int. J. Mod. Phys. D
Investigation of molecular mechanisms of diaphragmatic defects in the nitrofen-induced rat model of congenital diaphragmatic hernia
Creators: name: Takahashi, Toshiaki
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Developmental mutations that inhibit normal formation of extracellular matrix (ECM) in fetal diaphragms have been identified in congenital diaphragmatic hernia (CDH). FRAS1-related extracellular matrix 1 (FREM1) plays a critical role in the development of the fetal diaphragm. It has been demonstrated that a deficiency of FREM1 can lead to CDH both in humans and mice. Furthermore, FREM1-deficient fetuses exhibit a decreased level of mesenchymal cell proliferation in their developing diaphragms. FRAS1 and FRAS1-related extracellular matrix 2 (FREM2), which encode important ECM proteins, are secreted by mesenchymal cells during diaphragmatic development. The FRAS1/FREM2 gene unit has been shown to form a ternary complex with FREM1, which plays a crucial role during formation of human and rodent diaphragms. The first objective of this work was to investigate the morphological changes in the normal and abnormal diaphragm in the nitrofen rat model. The pleura-peritoneal folds (PPFs) in the control group were triangular-shaped structures protruding out from the lateral body wall, whereas nitrofen-exposed fetuses had an abnormal PPF structure, characterized by the absence of the dorsally projecting point of the triangular PPF. The second objectives was to investigate the expression levels and distribution of FREM1, FRAS1 and FREM2 genes and their proteins in the normal and abnormal diaphragm. In nitrofen-exposed fetuses, relative mRNA expression of FREM1, FRAS1 and FREM2 were significantly reduced in developing diaphragms compared to controls. Confocal laser scanning microscopy revealed markedly diminished FREM1, FRAS1 and FREM2 immunofluorescence in diaphragmatic mesenchyme, which was associated with reduced proliferation of mesenchymal cells in nitrofen-exposed fetuses compared to controls. Our results suggest that decreased mesenchymal expression of FREM1, FRAS1 and FREM2 in the nitrofen-induced CDH model may cause failure of the FREM1/FRAS1/FREM2 gene complex, disturbing the formation of diaphragmatic ECM and thus contributing to the development of diaphragmatic defects in CDH.
In-flight performance of the Canadian Astro-H Metrology System
Creators: name: Gallo, Luigi C.
name: Koujelev, Alexander
name: Gagnon, Stephane
name: Elgin, Timothy
name: Guibert, Martin
name: Iizuka, Ryo
name: Ishida, Manabu
name: Ishimura, Kosei
name: Iwata, Naoko
name: Kawano, Taro
name: Lambert, Casey
name: Moroso, Franco
name: Ueno, Shiro
name: Yuasa, Takayuki
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Canadian Astro-H Metrology System (CAMS) on the Hitomi X-ray satellite is a laser alignment system that measures the lateral displacement (X/Y) of the extensible optical bench (EOB) along the optical axis of the hard X-ray telescopes (HXTs). The CAMS consists of two identical units that together can be used to discern translation and rotation of the deployable element along the axis. This paper presents the results of in-flight usage of the CAMS during deployment of the EOB and during two observations (Crab and G21.5-0.9) with the HXTs. The CAMS was extremely important during the deployment operation by providing real-time positioning information of the EOB with micrometer scale resolution. In this work, we show how the CAMS improves data quality coming from the hard X-ray imagers. Moreover, we demonstrate that a metrology system is even more important as the angular resolution of the telescope increases. Such a metrology system will be an indispensable tool for future high resolution X-ray imaging missions.
description: 46 pages, 24 figures. Accepted for publication in JATIS
The Prevalence Rate of Pressure Ulcers in the Acute Hospital Setting and Investigating Three Methods of Prevalence Measurement.
Creators: name: O'Connor, Rosalind
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Aim: The aim of this study is to determine the prevalence of pressure ulcers in an acute hospital setting and investigate the value of using 3 different methods of pressure ulcer prevalence measurement. Method: A prospective quantitative research method was used. Pressure ulcers prevalence and risk was measured using Waterlow scores with visual inspection (using EPUAP guidelines), sub epidermal moisture measurement (using the S.E.M scanner) and pain associated with pressure ulcer development. A cohort of patients in acute hospital, who were mainly short stay surgical patients, were followed over a three day period with the measures of prevalence being taken each day. Results / Discussion: Of the 31 participants who took part the mean (±SD) of the Waterlow score was 6.8 (±4.0) indicating that 93.5% of participants were deemed low risk of pressure ulcer development. 2 patients (6.4%) showed visible signs of pressure ulcer (grade 1) development. The S.E.M. scanner revealed that 16 (51.4%) participants demonstrated signs of pressure injury. Pain was reported at all anatomical sites. All pain was reported as 'mild'. On average 12.8% (n=4) of participants verbalised pain at one or more of the anatomical sites. Correlational statistics demonstrate statistically significant association between immobility and S.E.M scores (r=.527, p=.010) and between EPUAP score s and S.E.M reading on the sacrum (r=.762, p=.000). No associations were found between pain and EPUAP scores or S.E.M scores. Conclusion: The result of this study indicate that there a possible underestimation of pressure ulcer prevalence rates when using Waterlow and visual inspection and that sub epidural moisture scanning is more sensitive in picking up early pressure damage. Pain measurement as a method of detecting pressure ulcers is not well supported in this study. The results call in to the question current methodologies in pressure ulcer risk assessment and detection particularly in short stay surgical patients.
Neutralino Annihilations and the Gas Temperature in the Dark Ages
Creators: name: Myers, Zac
name: Nusser, Adi
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Assuming the dark matter is made entirely from neutralinos, we re-visit the role of their annihilation on the temperature of diffuse gas in the high redshift universe. We consider neutralinos of particle mass 36 GeV and 100 GeV, respectively. The former is able to produce ~7 electron/positron particles per annihilation through the fremionic channel, and the latter ~53 particles assuming a purely bosonic channel. High energy electron/positron particles up-scatter the Cosmic Microwave Background (CMB) photons into higher energies via the inverse-Compton scattering. The process produces a power-law electron/positron energy spectrum of index -1 in the energy range of interest, independent of the initial energy distribution. The corresponding energy spectrum of the up-scattered photons is a power-law of index -1/2, if absorption by the gas is not included. The scattered photons photo-heat the gas by releasing electrons which deposit a fraction (14%)of their energy as heat into the ambient medium. For uniformly distributed neutralinos the heating is insignificant. The effect is greatly enhanced by the clumping of neutralinos into dense haloes. We use a time-dependent clumping model which takes into account the damping of density fluctuations on mass scales smaller than ~10^{-6}M_sol. With this clumping model, the heating mechanism boosts the gas temperature above that of the CMB after a redshift of z 30. By z\approx 10 the gas temperature is nearly 100 times its temperature when no heating is invoked. Similar increase is obtained for the two neutralino masses considered.
description: 8 pages, 6 figures, submitted to MNRAS
Additional file 1 of How have carbon stocks in central and southern Africa’s miombo woodlands changed over the last 50 years? A systematic map of the evidence
Creators: name: Davison Gumbo
name: Clendenning, Jessica
name: Martius, Christopher
name: Kaala Moombe
name: Grundy, Isla
name: Nasi, Robert
name: Kondwani Mumba
name: Ribeiro, Natasha
name: Kabwe, Gillian
name: Petrokofsky, Gillian
Publisher: name: figshare
Year: 2020
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 1. Literature search; showing literature sources, search strings, and keywords used.
Gamma Ray Bursts from Interaction of Relativistic Flows with Radiation Fields
Creators: name: Shemi, Amotz
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Relativistic flows resulting from sudden explosive events upscatter ambient interstellar photons of local radiation fields. For Lorentz factor $ > 100$ and dense optical - UV radiation fields the emergent signal is a typical gamma ray burst. Presumably the explosions occur in dense globular clusters or in galactic nuclei, at cosmological distances.
description: 10 pages, LaTeX, accepted for publication in the MNRAS
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00469
Creators: name: de la Côte-d'Or, Archives départementales
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00469, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Effects of the peroxisome proliferator-activated receptor y agonist rosiglitazone on foetal lung development in an experimental rat model of congenital diaphragmatic hernia.
Creators: name: Friedmacher, Florian Michael
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Congenital diaphragmatic hernia (CDH) is a prenatal defect in the integrity of the developing diaphragm, which results in severe pulmonary hypoplasia (PH) with alveolar immaturity. Peroxisome proliferator-activated receptor y (PPARy) plays a key role in foetal alveolarization by coordinating alveolar cell proliferation and differentiation, which results in enhanced expression of alveolar lipid-containing interstitial fibroblasts (LIFs). Furthermore, PPARy increases the lipid content of alveolar LIFs by upregulation of adipocyte differentiation-related protein (ADRP), a lipogenic marker for alveolar mesenchymal differentiation and physiological determinant for the synthesis of surfactant phospholipids. Since PPARy transcripts and alveolar LIFs are significantly decreased in hypoplastic rat lungs, the overall aim of this work was to investigate the hypothesis that the synthetic PPARy agonist rosiglitazone (RGZ) has the potential to improve foetal alveolar development in the nitrofen rat model of CDH-associated PH. The first objective of this work was to examine the in vitro effects of RGZ treatment in an explant culture of foetal rat lungs. Morphometric analysis revealed that daily administration of RGZ enhances alveolarization in nitrofen-exposed hypoplastic lungs compared to Placebo-treated lung explants, which was further supported by a significantly increased radial alveolar count and decreased mean linear intercept. The second objective was to evaluate the in vivo effects of prenatally administered RGZ on alveolar development and maturation in foetal rats with CDH. lmmunohistochemical/-fluorescence analysis demonstrated that maternal administration of RGZ shortly before birth stimulates epithelial and mesenchmal differentiation in nitrofen-induced PH compared to Placebo-treated foetuses, as evidenced by increased lamellar body count and ADRP expression. There was also a substantial accumulation of cytoplasmatic lipid droplets in alveolar interstitial cells, which was accompanied by a markedly increase of LIFs in the mesenchymal compartments of distal alveolar walls. Taken together, these results suggest that RGZ has a therapeutic potential in attenuating foetal PH in rats with nitrofen-induced CDH through accelerating epithelial-mesenchymal interactions, which may result in enhanced expression of LIFs and thus alveolar maturation.
MOESM2 of Iterative cycle of widely targeted metabolic profiling for the improvement of 1-butanol titer and productivity in Synechococcus elongatus
Creators: name: Artnice Fathima
name: Chuang, Derrick
name: LaviĂąa, Walter
name: Liao, James
name: Sastia Putri
name: Fukusaki, Eiichiro
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology

description: Additional file 2: Figure S1. Relative intensity of intracellular butanoyl-CoA, acetyl-CoA, and (iso-) citrate in BUOHSE and BUOHSE without pduP. Asterisks indicate significant differences in the strains (*: p â ¤ 0.05; **: p â ¤ 0.01). Figure S2. Colony PCR results for the segregation test in BUOHSE, DC7, and DC11 strain, W. T. (wild type strain), NSI (neutral site I), NSII (neutral site II). Figure S3. 1-Butanol production and cell density of S. elongatus obtained with the different RBS sequences.
Planetary Migration in Protoplanetary Disks
Creators: name: Nelson, Richard P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The known exoplanet population displays a great diversity of orbital architectures, and explaining the origin of this is a major challenge for planet formation theories. The gravitational interaction between young planets and their protoplanetary disks provides one way in which planetary orbits can be shaped during the formation epoch. Disk-planet interactions are strongly influenced by the structure and physical processes that drive the evolution of the protoplanetary disk. In this review we focus on how disk-planet interactions drive the migration of planets when different assumptions are made about the physics of angular momentum transport, and how it drives accretion flows in protoplanetary disk models. In particular, we consider migration in discs where: (i) accretion flows arise because turbulence diffusively transports angular momentum; (ii) laminar accretion flows are confined to thin, ionised layers near disk surfaces and are driven by the launching of magneto-centrifugal winds, with the midplane being completely inert; (iii) laminar accretion flows pervade the full column density of the disc, and are driven by a combination of large scale horizontal and vertical magnetic fields.
description: Invited review, accepted for publication in the 'Handbook of Exoplanets', eds. H.J. Deeg and J.A. Belmonte, Springer (2018). 29 pages, 4 figures
MOESM1 of How have carbon stocks in central and southern Africaâ s miombo woodlands changed over the last 50Â years? A systematic map of the evidence
Creators: name: Davison Gumbo
name: Clendenning, Jessica
name: Martius, Christopher
name: Kaala Moombe
name: Grundy, Isla
name: Nasi, Robert
name: Kondwani Mumba
name: Ribeiro, Natasha
name: Kabwe, Gillian
name: Petrokofsky, Gillian
Publisher: name: figshare
Year: 2018
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Literature search; showing literature sources, search strings, and keywords used.
title: ADCO, Cart. 186 (11 H 71), f. 0234r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0234r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Finite Approximations to Quantum Physics: Quantum Points and their Bundles
Creators: name: Balachandran, A. P.
name: Bimonte, G.
name: Ercolessi, E.
name: Teotonio-Sobrinho, P.
Publisher: name: arXiv
Year: 1993
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: There exists a physically well motivated method for approximating manifolds by certain topological spaces with a finite or a countable set of points. These spaces, which are partially ordered sets (posets) have the power to effectively reproduce important topological features of continuum physics like winding numbers and fractional statistics, and that too often with just a few points. In this work, we develop the essential tools for doing quantum physics on posets. The poset approach to covering space quantization, soliton physics, gauge theories and the Dirac equation are discussed with emphasis on physically important topological aspects. These ideas are illustrated by simple examples like the covering space quantization of a particle on a circle, and the sine-Gordon solitons.
description: 24 pages, 8 figures on a uuencoded postscript file, DSF-T-29/93, INFN-NA-IV-29/93 and SU-4240-550
Instance Optimal Decoding and the Restricted Isometry Property
Creators: name: Keriven, Nicolas
name: Gribonval, Rémi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Information Theory (cs.IT)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In this paper, we address the question of information preservation in ill-posed, non-linear inverse problems, assuming that the measured data is close to a low-dimensional model set. We provide necessary and sufficient conditions for the existence of a so-called instance optimal decoder, i.e., that is robust to noise and modelling error. Inspired by existing results in compressive sensing, our analysis is based on a (Lower) Restricted Isometry Property (LRIP), formulated in a non-linear fashion. We also provide sufficient conditions for non-uniform recovery with random measurement operators, with a new formulation of the LRIP. We finish by describing typical strategies to prove the LRIP in both linear and non-linear cases, and illustrate our results by studying the invertibility of a one-layer neural net with random weights.
Nuclear deformation effect on the binding energies in heavy ions
Creators: name: Kozhedub, Y. S.
name: Andreev, O. V.
name: Shabaev, V. M.
name: Tupitsyn, I. I.
name: Brandau, C.
name: Kozhuharov, C.
name: Plunien, G.
name: Stohlker, T.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Nuclear deformation effects on the binding energies in heavy ions are investigated. Approximate formulas for the nuclear-size correction and the isotope shift for deformed nuclei are derived. Combined with direct numerical evaluations, these formulas are employed to reanalyse experimental data on the nuclear-charge-distribution parameters in $^{238}\textrm{U}$ and to revise the nuclear-size corrections to the binding energies in H- and Li-like $^{238}\textrm{U}$. As a result, the theoretical uncertainties for the ground-state Lamb shift in $^{238}\textrm{U}^{91+}$ and for the $2p_{1/2}-2s$ transition energy in $^{238}\textrm{U}^{89+}$ are significantly reduced. The isotope shift of the $2p_{j}-2s$ transition energies for $^{142}\textrm{Nd}^{57+}$ and $^{150}\textrm{Nd}^{57+}$ is also evaluated including nuclear size and nuclear recoil effects within a full QED treatment.
description: 19 pages, 5 tables
Uncertainties in Coupling Constant Unification
Creators: name: Langacker, Paul
name: Polonsky, Nir
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The status of coupling constant unification in the standard model and its supersymmetric extension are discussed. Uncertainties associated with the input coupling constants, $m_{t}$, threshold corrections at the low and high scales, and possible nonrenormalizable operators are parametrized and estimated. A simple parametrization of a general supersymmetric new particle spectrum is given. It is shown that an effective scale $M_{SUSY}$ can be defined, but for a realistic spectrum it may differ considerably from the typical new particle masses. The implications of the lower (higher) values of $α_{s}(M_{Z})$ suggested by low-energy ($Z$-pole) experiments are discussed.
description: LaTex, 51 pages, 6 figures (available upon request), UPR-0513T
Globular clusters: absolute proper motions and Galactic orbits
Creators: name: Chemel, A. A.
name: Glushkova, E. V.
name: Dambis, A. K.
name: Rastorguev, A. S.
name: Yalyalieva, L. N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We cross-match objects from several different astronomical catalogs to determine the absolute proper proper motions of stars within the 30-arcmin radius fields of 115 Milky-Way globular clusters with the accuracy of 1--2~mas/yr. The proper motions are based on positional data recovered from the USNO-B1, 2MASS, URAT1, ALLWISE, UCAC5, and GAIA DR1 surveys with up to 10 positions spanning an epoch difference of up to $\sim$~65~years, and reduced to GAIA DR1 TGAS frame using UCAC5 as the reference catalog. Cluster members are photometrically identified by selecting horizontal- and red-giant branch stars on color-magnitude diagrams, and the mean absolute proper motions of the clusters with a typical formal error of $\sim$~0.4~mas/yr are computed by averaging the proper motions of selected members. The inferred absolute proper motions of clusters are combined with available radial-velocity data and heliocentric distance estimates to compute the cluster orbits in terms of the Galactic potential models based on Miyamoto and Nagai disk, Hernquist spheroid, and modified isothermal dark-matter halo (axisymmetric model without a bar) and the same model + rotating Ferre's bar (non-axisymmetric). Five distant clusters have higher-than-escape velocities, most likely due to large errors of computed transversal velocities, whereas the computed orbits of all other clusters remain bound to the Galaxy. Unlike previously published results, we find the bar to affect substantially the orbits of most of the clusters, even those at large Galactocentric distances, bringing appreciable chaotization, especially in the portions of the orbits close to the Galactic center, and stretching out the orbits of some of the thick-disk clusters.
description: 14 pages, 14 figures, 3 tables, to appear in Astrophysical Bulletin. Table 1 replaced by corrected version (Tables 2 and 3 are based on correct data and remain unchanged)
Gravitational attraction until relativistic equipartition of internal and translational kinetic energies
Creators: name: Bulyzhenkov, I. E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: Translational ordering of the internal kinematic chaos provides the Special Relativity referents for the geodesic motion of warm thermodynamical bodies. Taking identical mathematics, relativistic physics of the low speed transport of time-varying heat-energies differs from Newton's physics of steady masses without internal degrees of freedom. General Relativity predicts geodesic changes of the internal heat-energy variable under the free gravitational fall and the geodesic turn in the radial field center. Internal heat variations enable cyclic dynamics of decelerated falls and accelerated takeoffs of inertial matter and its structural self-organization. The coordinate speed of the ordered spatial motion takes maximum under the equipartition of relativistic internal and translational kinetic energies. Observable predictions are discussed for verification/falsification of the principle of equipartition as a new basic for the ordered motion and self-organization in external fields, including gravitational, electromagnetic, and thermal ones.
A Simple Model for Cavity Enhanced Slow Lights in Vertical Cavity Surface Emission Lasers
Creators: name: Chou, Chia-Sheng
name: Lee, Ray-Kuang
name: Peng, Peng-Chun
name: Kuo, Hao-chung
name: Lin, Gray
name: Yang, Hung-Ping
name: Chi, Jim Y.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We develop a simple model for the slow lights in Vertical Cavity Surface Emission Lasers (VCSELs), with the combination of cavity and population pulsation effects. The dependences of probe signal power, injection bias current and wavelength detuning for the group delays are demonstrated numerically and experimentally. Up to 65 ps group delays and up to 10 GHz modulation frequency can be achieved in the room temperature at the wavelength of 1.3 $μ$m. The most significant feature of our VCSEL device is that the length of active region is only several $μ$m long. Based on the experimental parameters of quantum dot VCSEL structures, we show that the resonance effect of laser cavity plays a significant role to enhance the group delays.
On the interior geometry of a typical black hole microstate
Creators: name: de Boer, Jan
name: van Breukelen, Rik
name: Lokhande, Sagar F.
name: Papadodimas, Kyriakos
name: Verlinde, Erik
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We argue that the region behind the horizon of a one-sided black hole can be probed by an analogue of the double-trace deformation protocol of Gao-Jafferis-Wall. This is achieved via a deformation of the CFT Hamiltonian by a term of the form ${\cal O} \widetilde{\cal O}$, where $\widetilde{\cal O}$ denote the state-dependent "mirror operators". We argue that this deformation creates negative energy shockwaves in the bulk, which allow particles inside the horizon to escape and to get directly detected in the CFT. This provides evidence for the smoothness of the horizon of black holes dual to typical states. We argue that the mirror operators allow us to perform an analogue of the Hayden-Preskill decoding protocol. Our claims rely on a technical conjecture about the chaotic behavior of out-of-time-order correlators on typical pure states at scrambling time.
description: 5 pages
Graphbasierte Transformationen für modellgetriebene Softwareentwicklung
Creators: name: Pointner, Andreas
Publisher: name: Zenodo
Year: 2019
Subjects: Modell Transformation

description: Die Modelltransformation ist ein wesentlicher Teil der modernen Softwareentwicklung. Gerade im Bereich des Model-Driven Development (MDD) gibt es einige spannende neue Themen und Inhalte. Diese Arbeit legt den Fokus dabei auf die Entwicklung eines graphbasierten Modelltransformationsframeworks. Im Zuge dieser Arbeit werden dafür die Grundlagen der Modelltransformation beschrieben. Darunter fällt auch die Definition von Modellen, Metamodellen, aber auch welche Arten von Transformationen existieren. Darüber hinaus werden einige theoretische Konzepte wie Triple Graph Grammar (TGG) analysiert, aber auch detailliert auf bestehende Frameworks wie Atlas Transformation Language (ATL) und Epsilon Transformation Language (ETL) eingegangen. Zusätzlich dazu wird ein Konzept vorgestellt, wie die Graphdatenbank Neo4J zur Modelltransformation verwendet werden kann, beziehungsweise wie sie sich mit einem Modelltransformationsframework verbinden lässt. Das Kernthema dieser Arbeit ist dabei das Design und die Implementierung der Graphtransformationsbibliothek. Dabei wird auf die entwickelten Konzepte und verwendeten Entwurfsmuster eingegangen, sowie die Analogien zu den zuvor analysierten Frameworks aufgezeigt. Diese Bibliothek wird dann anhand zweier Beispiele, der Transformation eines Graphen in ein XML Modell und der Transformation eines 2D Bauplanes in ein 3D Modell, welche im Zuge einer Forschungsarbeit entstand, evaluiert. Abschließend wird auf die jeweiligen Vor- und Nachteile der Bibliothek eingegangen und ein Ausblick für zukünftige Entwicklungen gegeben. Dabei zeigt sich, dass vor allem die Unabhängigkeit zu anderen Technologien, sowie die lose Koppelung der Komponenten ein wesentlicher Vorteil der Bibliothek ist. Es zeigt sich aber auch, dass große Modelltransformationsframeworks wesentlich mehr Funktionalität zur Transformation bieten, diese aber häufig auch mit großem Overhead verbunden sind.