cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Systematic variation in gene expression patterns in human cancer cell lines
Creators: name: Scherf, Uwe
name: Iyer, Vishwanath
name: Van de Rijn, Matt
name: Rees, Christian
name: Myers, Timothy G.
name: Pergamenschikov, Alexander
name: Lashkari, Deval
name: Weinstein, John N.
name: Shalon, Dari
name: Brown, Patrick O.
name: Lee, Jeffrey C.F.
name: Ross, Douglas T.
name: Eisen, Michael B.
name: Perou, Charles M.
name: Waltham, Mark
name: Spellman, Paul
name: Jeffrey, Stefanie S.
name: Botstein, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs. Classification of the cell lines based solely on the observed patterns of gene expression revealed a correspondence to the ostensible origins of the tumours from which the cell lines were derived. The consistent relationship between the gene expression patterns and the tissue of origin allowed us to recognize outliers whose previous classification appeared incorrect. Specific features of the gene expression patterns appeared to be related to physiological properties of the cell lines, such as their doubling time in culture, drug metabolism or the interferon response. Comparison of gene expression patterns in the cell lines to those observed in normal breast tissue or in breast tumour specimens revealed features of the expression patterns in the tumours that had recognizable counterparts in specific cell lines, reflecting the tumour, stromal and inflammatory components of the tumour tissue. These results provided a novel molecular characterization of this important group of human cell lines and their relationships to tumours in vivo.
Empirical validation of the thermal model of a passive solar cell test
Creators: name: Mara, T. A.
name: Garde, F.
name: Boyer, H.
name: Mamode, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: The paper deals with an empirical validation of a building thermal model. We put the emphasis on sensitivity analysis and on research of inputs/residual correlation to improve our model. In this article, we apply a sensitivity analysis technique in the frequency domain to point out the more important parameters of the model. Then, we compare measured and predicted data of indoor dry-air temperature. When the model is not accurate enough, recourse to time-frequency analysis is of great help to identify the inputs responsible for the major part of error. In our approach, two samples of experimental data are required. The first one is used to calibrate our model the second one to really validate the optimized model.
Stellar Populations and the Star Formation Histories of LSB Galaxies: II. HII Regions
Creators: name: Schombert, James
name: McGaugh, Stacy
name: Maciel, Tamela
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The luminosities, colors and Hα emission for 429 HII regions in 54 LSB galaxies are presented. While the number of HII regions per galaxy is lower in LSB galaxies compared to star-forming irregulars and spirals, there is no indication that the size or luminosity function of HII regions differs from other galaxy types. The lower number of HII regions per galaxy is consistent with their lower total star formation rates. The fraction of total $L_{Hα}$ contributed by HII regions varies from 10 to 90% in LSB galaxies (the rest of the H$α$ emission being associated with a diffuse component) with no correlation with galaxy stellar or gas mass. Bright HII regions have bluer colors, similar to the trend in spirals; their number and luminosities are consistent with the hypothesis that they are produced by the same HII luminosity function as spirals. Comparison with stellar population models indicates that the brightest HII regions in LSB galaxies range in cluster mass from a few $10^3 M_{\sun}$ (e.g., $ρ$ Oph) to globular cluster sized systems (e.g., 30 Dor) and that their ages are consistent with clusters from 2 to 15 Myrs old. The faintest HII regions are comparable to those in the LMC powered by a single O or B star. Thus, star formation in LSB galaxies covers the full range of stellar cluster mass.
description: 25 pages, 13 figures, accepted in A.J
Sorbus torminalis
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. torminalis (L.) Crantz Cat. XLIVund 141. Fehlt dem Wallis als urwüchsige Art; nur gepflanzt.
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Research Note: More on improving service quality measurement
Creators: name: Parasuraman, A.
name: Berry, Leonard L.
name: Zeithaml, Valarie A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: In this note we respond to Brown, Churchill, and Peter's (1993) critique of SERVQUAL's difference-score conceptualization. We demonstrate that the claimed psychometric superiority of the alternative non-difference score conceptualization is debatable. We also argue that the SERVQUAL conceptualization offers richer diagnostics.
α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells
Creators: name: Lazarides, Elias
name: Burridge, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1975

description: Antibodies specific for the skeletal muscle structural protein α-actinin are used to localize this protein by indirect immunofluorescence in nonmuscle cells. In cultured nonmuscle cells, α-actinin is localized along or between actin filament bundles producing an almost regular periodicity. The protein is also detected in the form of fluorescent plaques at some ends of actin filament bundles, as well as in a filamentous form in some overlap areas of cells. In spreading rat embryo cells, α-actinin assumes a focal distribution which corresponds to the vertices of a highly regular actin filament network. The results suggest that α-actinin may be involved in the organization of actin filament bundles, in the attachment of actin filaments to the plasma membrane, and in the assembly of actin filaments in areas of cell to cell contact.
An integrated map of genetic variation from 1,092 human genomes
Creators: name: Li, Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations.
Preconception maternal nutrition: a multi-site randomized controlled trial
Creators: name: Figueroa, Lester
name: Derman, Richard J
name: Kodkany, Balachandra S
name: Das, Abhik
name: Goldenberg, Robert L
name: Krebs, Nancy F
name: Bose, Carl
name: Frank, Daniel N
name: Koso-Thomas, Marion
name: Garces, Ana
name: Friedman, Jacob E
name: Stolka, Kristen
name: Sundberg, Shelly
name: McClure, Elizabeth M
name: Westcott, Jamie E
name: Hambidge, K
name: Pasha, Omrana
name: Tshefu, Antoinette
name: Goudar, Shivaprasad S
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background Research directed to optimizing maternal nutrition commencing prior to conception remains very limited, despite suggestive evidence of its importance in addition to ensuring an optimal nutrition environment in the periconceptional period and throughout the first trimester of pregnancy. Methods/Study design This is an individually randomized controlled trial of the impact on birth length (primary outcome) of the time at which a maternal nutrition intervention is commenced: Arm 1: ≥ 3 mo preconception vs. Arm 2: 12-14 wk gestation vs. Arm 3: none. 192 (derived from 480) randomized mothers and living offspring in each arm in each of four research sites (Guatemala, India, Pakistan, Democratic Republic of the Congo). The intervention is a daily 20 g lipid-based (118 kcal) multi-micronutient (MMN) supplement. Women randomized to receive this intervention with body mass index (BMI) <20 or whose gestational weight gain is low will receive an additional 300 kcal/d as a balanced energy-protein supplement. Researchers will visit homes biweekly to deliver intervention and monitor compliance, pregnancy status and morbidity; ensure prenatal and delivery care; and promote breast feeding. The primary outcome is birth length. Secondary outcomes include: fetal length at 12 and 34 wk; incidence of low birth weight (LBW); neonatal/infant anthropometry 0-6 mo of age; infectious disease morbidity; maternal, fetal, newborn, and infant epigenetics; maternal and infant nutritional status; maternal and infant microbiome; gut inflammatory biomarkers and bioactive and nutritive compounds in breast milk. The primary analysis will compare birth Length-for-Age Z-score (LAZ) among trial arms (independently for each site, estimated effect size: 0.35). Additional statistical analyses will examine the secondary outcomes and a pooled analysis of data from all sites. Discussion Positive results of this trial will support a paradigm shift in attention to nutrition of all females of child-bearing age. Trial registration ClinicalTrials.gov NCT01883193 .
THEMIS Observations of the Magnetopause Electron Diffusion Region: Large Amplitude Waves and Heated Electrons
Creators: name: Tang, Xiangwei
name: Cattell, Cynthia
name: Dombeck, John
name: Dai, Lei
name: Wilson, Lynn B.
name: Breneman, Aaron
name: Hupach, Adam
Publisher: name: arXiv
Year: 2013
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We present the first observations of large amplitude waves in a well-defined electron diffusion region at the sub-solar magnetopause using data from one THEMIS satellite. These waves identified as whistler mode waves, electrostatic solitary waves, lower hybrid waves and electrostatic electron cyclotron waves, are observed in the same 12-sec waveform capture and in association with signatures of active magnetic reconnection. The large amplitude waves in the electron diffusion region are coincident with abrupt increases in electron parallel temperature suggesting strong wave heating. The whistler mode waves which are at the electron scale and enable us to probe electron dynamics in the diffusion region were analyzed in detail. The energetic electrons (~30 keV) within the electron diffusion region have anisotropic distributions with T_{e\perp}/T_{e\parallel}>1 that may provide the free energy for the whistler mode waves. The energetic anisotropic electrons may be produced during the reconnection process. The whistler mode waves propagate away from the center of the 'X-line' along magnetic field lines, suggesting that the electron diffusion region is a possible source region of the whistler mode waves.
Collective synchrony of mating signals modulated by ecological cues and social signals in bioluminescent sea fireflies
Creators: name: Hensley, Nicholai
name: Rivers, Trevor
name: Gerrish, Gretchen
name: Saha, Raj
name: Oakley, Todd
Publisher: name: Zenodo
Year: 2023
Subjects: collective behaviour
Ostracoda
synchrony
sea firefly
mating signal
Bioluminescence

description: Individuals often employ simple rules that can emergently synchronise behaviour. Some collective behaviours are intuitively beneficial, but others like mate signalling in leks occur across taxa despite theoretical individual costs. Whether disparate instances of synchronous signalling are similarly organised is unknown, largely due to challenges observing many individuals simultaneously. Recording field collectives and ex situ playback experiments, we describe principles of synchronous bioluminescent signals produced by marine ostracods (Crustacea; Luxorina) that seem behaviorally convergent with terrestrial fireflies, and with whom they last shared a common ancestor over 500 mya. Like synchronous fireflies, groups of signalling males use visual cues (intensity and duration of light) to decide when to signal. Individual ostracods also modulate their signal based on the distance to nearest neighbours. During peak darkness, luminescent "waves" of synchronous displays emerge and ripple across the sea floor every ~60 seconds, but such periodicity decays within and between nights after the full moon. Our data reveal these bioluminescent aggregations are sensitive to both ecological and social light sources. Because the function of collective signals is difficult to dissect, evolutionary convergence, like in the synchronous visual displays of diverse arthropods, provides natural replicates to understand the generalities that produce emergent group behaviour.
description: Funding provided by: National Science FoundationCrossref Funder Registry ID: https://ror.org/021nxhr62Award Number: DEB-1457754
Funding provided by: National Science FoundationCrossref Funder Registry ID: https://ror.org/021nxhr62Award Number: DEB-1457439
Funding provided by: Smithsonian Tropical Research InstituteCrossref Funder Registry ID: https://ror.org/02ptchg16Award Number:
Funding provided by: American Museum of Natural HistoryCrossref Funder Registry ID: https://ror.org/03thb3e06Award Number:
Funding provided by: Sigma XiCrossref Funder Registry ID: https://ror.org/04nmj5x57Award Number:
description: Data are a mixture of types from different methods and experiments. They are most clearly outliend and used in conjunciton with the provided R code for context. Briefly, the majority of data are from observations of collective bioluminescent behaviors of wild, naturally kept, or experimentally manipulated ostracods (marine crustaceans). We used either cameras or human observations to record data. Camera data was either post-processed using computer vision or annotated by eye to record the number of bright pixels or number of behaviors, respectively. One data set was collected with a spectroradiometer, as described in the methods of the paper. Images in the dataset are demonstrative of the methods.
A prospective analysis of the effect of neighbourhood and individual social capital on changes in self-rated health of people with chronic illness
Creators: name: Waverijn, Geeke
name: Groenewegen, Peter
name: Rijken, Mieke
name: Mohnen, Sigrid
name: Spreeuwenberg, Peter
name: Wolfe, Mary K.
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract: Background: Social capital in the living environment, both on the individual and neighbourhood level, is positively associated with people’s self-rated health; however, prospective and longitudinal studies are rare, making causal conclusions difficult. To shed more light on the direction of the relationship between social capital and self-rated health, we investigated main and interaction effects of individual and neighbourhood social capital at baseline on changes in self-rated health of people with a somatic chronic disease. Methods: Individual social capital, self-rated health and other individual level variables were assessed among a nationwide sample of 1048 non-institutionalized people with a somatic chronic disease residing in 259 neighbourhoods in the Netherlands. The assessment of neighbourhood social capital was based on data from a nationwide survey among the general Dutch population. The association of social capital with changes in self-rated health was assessed by multilevel regression analysis. Results: Both individual social capital and neighbourhood social capital at baseline were significantly associated with changes in self-rated health over the time period of 2005 to 2008 while controlling for several disease characteristics, other individual level and neighbourhood level characteristics. No significant interactions were found between social capital on the individual and on the neighbourhood level. Conclusions: Higher levels of individual and neighbourhood social capital independently and positively affect changes in self-rated health of people with chronic illness. Although most of the variation in health is explained at the individual level, one’s social environment should be considered as a possible relevant influence on the health of the chronically ill.
Parallel and distributed optimization methods for estimation and control in networks
Creators: name: Necoara, Ion
name: Nedelcu, Valentin
name: Dumitrache, Ioan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: System performance for networks composed of interconnected subsystems can be increased if the traditionally separated subsystems are jointly optimized. Recently, parallel and distributed optimization methods have emerged as a powerful tool for solving estimation and control problems in large-scale networked systems. In this paper we review and analyze the optimization-theoretic concepts of parallel and distributed methods for solving coupled optimization problems and demonstrate how several estimation and control problems related to complex networked systems can be formulated in these settings. The paper presents a systematic framework for exploiting the potential of the decomposition structures as a way to obtain different parallel algorithms, each with a different tradeoff among convergence speed, message passing amount and distributed computation architecture. Several specific applications from estimation and process control are included to demonstrate the power of the approach.
description: 36 pages
Preservice school counselors’ perceptions of giftedness: Myths and misconceptions
Creators: name: Tuzgen, Abdullah
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Educational psychology

description: Conceptions of giftedness have changed since gifted education became a focus for research. Rather than focusing solely on scores such as grades or Grade Point Average, definitions of giftedness have become more inclusive, and giftedness evaluation criteria have become more holistic. Despite the growing research, few studies have specifically investigated school counselors' perceptions of giftedness, and even fewer have examined the perceptions of preservice counselors. This study seeks to address this gap by examining pre-service school counselors by employing a qualitative descriptive approach, supplemented with quantitative information. The study involved 176 Turkish and 56 US survey participants, as well as 13 Turkish and eight U.S. interviewees. After I analyzed the data from these two countries, the primary finding of the research was that the participants demonstrated an insufficient understanding of giftedness, often subscribing to myths that perpetuate in the field. Consequently, the major implication of this study is that there is a pressing need for more comprehensive training and mandatory coursework on gifted education for preservice school counselors.
title: More-than-Human Design: A Mindful Intervention into Design
Creators: name: Gholami, Kimia
Publisher: name: Emily Carr University of Art and Design
Year: 2022
Subjects: subject: Design
valueUri: https://id.loc.gov/authorities/subjects/sh85037197
subject: Methodology
valueUri: https://id.loc.gov/authorities/subjects/sh85084414
subject: Ecology
valueUri: https://id.loc.gov/authorities/subjects/sh85040752
subject: FOS: Biological sciences
subject: Nature
valueUri: https://id.loc.gov/authorities/subjects/sh85090277

description: This research is a critical quest to develop an inclusive More-than-Human (MtH) Design Process that recognizes non-human beings as valuable participants. This approach is meant to actively acknowledge the interconnectedness and interdependence of humans and other beings and act as an intervention in different stages of the “Design Thinking” process that is based on human-centred values. Through an MtH lens, this thesis questions the short-term profit-based model in the design industry that primarily benefits humans while bringing destructive consequences to the rest of the living planet. These consequences, such as global warming, loss of biodiversity, and environmental destruction, have foregrounded the need to take the agency of non-humans more seriously in the design discipline. The MtH Design Process expands the human-centred design methodology by borrowing methods from Interaction Design (IxD) and More-than-Human Participatory Research (MtH-PR). This work has been structured in four main sections. In part 1, re-frame, we start our inquiry by looking at Interaction Design from a More-than-Human perspective. We include a series of place-based explorations in Vancouver B.C that challenged our old assumptions and biases towards different participants in design. In part 2, re-imagine, we work towards an MtH design practice by identifying its core values. These values guide several case studies that demonstrate how an MtH approach can alter existing products. Part 3, re-build, focuses on formalising the MtH design process by creating changes in different phases of the Design Thinking process. The MtH Design Process includes five steps – 1. Encounter 2. Learn 3. Plan 4. Map and 5. Build – all of which offer multiple methods, prompts, and points of inquiry into the MtH design practice. This work also includes the MtH design toolkit to support its pedagogical potential. The final part, re-connect, concludes the work by discussing the implications of MtH design and its potentials and challenges.
A validation methodology aid for improving a thermal building model: Case of diffuse radiation accounting in a tropical climate
Creators: name: Lauret, A. J. P.
name: Mara, T. A.
name: Boyer, H.
name: Adelard, L.
name: Garde, F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: As part of our efforts to complete the software CODYRUN validation, we chose as test building a block of flats constructed in Reunion Island, which has a humid tropical climate. The sensitivity analysis allowed us to study the effects of both diffuse and direct solar radiation on our model of this building. With regard to the choice and location of sensors, this stage of the study also led us to measure the solar radiation falling on the windows. The comparison of measured and predicted radiation clearly showed that our predictions over-estimated the incoming solar radiation, and we were able to trace the problem to the algorithm which calculates diffuse solar radiation. By calculating view factors between the windows and the associated shading devices, changes to the original program allowed us to improve the predictions, and so this article shows the importance of sensitivity analysis in this area of research.
Perioperative morbidity of different operative approaches in early cervical carcinoma: a systematic review and meta-analysis comparing minimally invasive versus open radical hysterectomy
Creators: name: Kampers, J.
name: Gerhardt, E.
name: Sibbertsen, P.
name: Flock, T.
name: Hertel, H.
name: Klapdor, R.
name: Jentschke, M.
name: Hillemanns, P.
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2021
Subjects: subject: Early cervical cancer
subject: Laparoscopy
subject: Minimally-invasive
subject: Postoperative morbidity
subject: Radical hysterectomy
subject: Robot-assisted
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Purpose: Radical hysterectomy and pelvic lymphadenectomy is the standard treatment for early cervical cancer. Studies have shown superior oncological outcome for open versus minimal invasive surgery, but peri- and postoperative complication rates were shown vice versa. This meta-analysis evaluates the peri- and postoperative morbidities and complications of robotic and laparoscopic radical hysterectomy compared to open surgery. Methods: Embase and Ovid-Medline databases were systematically searched in June 2020 for studies comparing robotic, laparoscopic and open radical hysterectomy. There was no limitation in publication year. Inclusion criteria were set analogue to the LACC trial. Subgroup analyses were performed regarding the operative technique, the study design and the date of publication for the endpoints intra- and postoperative morbidity, estimated blood loss, hospital stay and operation time. Results: 27 studies fulfilled the inclusion criteria. Five prospective, randomized-control trials were included. Meta-analysis showed no significant difference between robotic radical hysterectomy (RH) and laparoscopic hysterectomy (LH) concerning intra- and perioperative complications. Operation time was longer in both RH (mean difference 44.79 min [95% CI 38.16; 51.42]), and LH (mean difference 20.96 min; [95% CI − 1.30; 43.22]) than in open hysterectomy (AH) but did not lead to a rise of intra- and postoperative complications. Intraoperative morbidity was lower in LH than in AH (RR 0.90 [0.80; 1.02]) as well as in RH compared to AH (0.54 [0.33; 0.88]). Intraoperative morbidity showed no difference between LH and RH (RR 1.29 [0.23; 7.29]). Postoperative morbidity was not different in any approach. Estimated blood loss was lower in both LH (mean difference − 114.34 [− 122.97; − 105.71]) and RH (mean difference − 287.14 [− 392.99; − 181.28]) compared to AH, respectively. Duration of hospital stay was shorter for LH (mean difference − 3.06 [− 3.28; − 2.83]) and RH (mean difference − 3.77 [− 5.10; − 2.44]) compared to AH. Conclusion: Minimally invasive radical hysterectomy appears to be associated with reduced intraoperative morbidity and blood loss and improved reconvalescence after surgery. Besides oncological and surgical factors these results should be considered when counseling patients for radical hysterectomy and underscore the need for new randomized trials. © 2021, The Author(s).
Health Behavior Theory and cumulative knowledge regarding health behaviors: Are we moving in the right direction?
Creators: name: Zimmerman, Rick S.
name: Noar, Seth M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Although research on Health Behavior Theory (HBT) is being conducted at a rapid pace, the extent to which the field is truly moving forward in understanding health behavior has been questioned. This issue is examined in the current article. First, we discuss the problems within the HBT literature. Second, we discuss the proliferation of HBT and why theory comparison is essential to this area of research. Finally, we reflect on ways that the field might move forward by suggesting a new agenda for HBT research. It is argued that increased recognition of the similarity of health behavior constructs as well as increased empirical comparisons of theories are essential for true scientific progress in this line of inquiry.
Extended Data- Experience and Perceptions of Social Prescribing interventions; a Qualitative study with people with Long-term conditions, Link workers and Health care providers. Authors: O’Sullivan D, Bearne LM., Harrington J, McVeigh JG
Creators: name: O' Sullivan, Declan
Publisher: name: figshare
Year: 2023
Subjects: Physiotherapy
Rehabilitation
Allied health and rehabilitation science not elsewhere classified

description: This contains Extended Data from the following study: Experience and Perceptions of Social Prescribing interventions; a Qualitative study with people with Long-term conditions, Link workers and Health care providers: a study protocol Authors: O’Sullivan D, Bearne LM., Harrington J, McVeigh JG
 Appendix 1 Participant Information Sheet-Patient Appendix 2 Participant Information Sheet-Link Worker Appendix 3 Participant Information Sheet-Healthcare Provider Appendix 4 Participant Information Sheet- Community based service Appendix 5 Consent form Appendix 6 Email to 'gatekeeper'-link worker Appendix 7 Email to 'gatekeeper'-Healthcare provider Appendix 8 Email to GP clinics Appendix 9 Interview guide Appendix 10 Protocol Amendment History
Plane waves as tractor beams
Creators: name: Forgács, Péter
name: Lukács, Árpád
name: Romańczukiewicz, Tomasz
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: It is shown that in a large class of systems plane waves can act as tractor beams: i.e., an incident plane wave can exert a pulling force on the scatterer. The underlying physical mechanism for the pulling force is due to the sufficiently strong scattering of the incoming wave into another mode having a larger wave number, in which case excess momentum is created behind the scatterer. Such a tractor beam or negative radiation pressure effect arises naturally in systems where the coupling between the scattering channels is due to Aharonov-Bohm (AB) gauge potentials. It is demonstrated that this effect is also present if the AB potential is an induced, ("artificial") gauge potential such as the one found in J. March-Russell, J. Preskill, F. Wilczek, Phys. Rev. Lett. 58 2567 (1992).
description: 6 pages, 4 figures
Smallest state spaces for which bipartite entangled quantum states are separable
Creators: name: Anwar, H.
name: Jevtic, S.
name: Rudolph, O.
name: Virmani, S.
Publisher: name: Bristol : Institute of Physics Publishing
Year: 2015
Subjects: subject: Decomposition
subject: Quantum entanglement
subject: Quantum optics
subject: Wave functions
subject: Wigner-Ville distribution
subject: Discrete Wigner function
subject: Entangled state
subject: Hidden variable
subject: separability
subject: Tensor norm
subject: Quantum theory
subject: bipartite entangled states
subject: discrete wigner function
subject: local hidden variables
subject: projective tensor norm
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: According to usual definitions, entangled states cannot be given a separable decomposition in terms of products of local density operators. If we relax the requirement that the local operators be positive, then an entangled quantum state may admit a separable decomposition in terms of more general sets of single-system operators. This form of separability can be used to construct classical models and simulation methods when only a restricted set of measurements is available. With these motivations in mind, we ask what are the smallest sets of local operators such that a pure bipartite entangled quantum state becomes separable? We find that in the case of maximally entangled states there are many inequivalent solutions, including for example the sets of phase point operators that arise in the study of discrete Wigner functions. We therefore provide a new way of interpreting these operators, and more generally, provide an alternative method for constructing local hidden variable models for entangled quantum states under subsets of quantum measurements. © 2015 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.
Unconventional phases of attractive Fermi gases in synthetic Hall ribbons
Creators: name: Ghosh, Sudeep Kumar
name: Greschner, Sebastian
name: Yadav, Umesh K.
name: Mishra, Tapan
name: Rizzi, Matteo
name: Shenoy, Vijay B.
Publisher: name: College Park, MD : American Physical Society
Year: 2017
Subjects: subject: Atoms
subject: Electron gas
subject: Fermions
subject: Ground state
subject: Hadrons
subject: Numerical methods
subject: Optical lattices
subject: Phase separation
subject: Statistical mechanics
subject: Wave functions
subject: Attractive interactions
subject: Density matrix renormalization group methods
subject: Fermionic systems
subject: Ground state phase diagram
subject: Hyperfine state
subject: One dimensional optical lattice
subject: Pairing correlations
subject: Shedding light
subject: Quantum theory
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: An innovative way to produce quantum Hall ribbons in a cold atomic system is to use M hyperfine states of atoms in a one-dimensional optical lattice to mimic an additional "synthetic dimension." A notable aspect here is that the SU(M) symmetric interaction between atoms manifests as "infinite ranged" along the synthetic dimension. We study the many-body physics of fermions with SU(M) symmetric attractive interactions in this system using a combination of analytical field theoretic and numerical density-matrix renormalization-group methods. We uncover the rich ground-state phase diagram of the system, including unconventional phases such as squished baryon fluids, shedding light on many-body physics in low dimensions. Remarkably, changing the parameters entails interesting crossovers and transition; e.g., we show that increasing the magnetic field (that produces the Hall effect) converts a "ferrometallic" state at low fields to a "squished baryon superfluid" (with algebraic pairing correlations) at high fields. We also show that this system provides a unique opportunity to study quantum phase separation in a multiflavor ultracold fermionic system. © 2017 American Physical Society.
Seed selection strategies for information diffusion in social networks: An agent-based model applied to rural zambia
Creators: name: Nöldeke, Beatrice
name: Winter, Etti
name: Grote, Ulrike
Publisher: name: Guildford : University of Surrey
Year: 2020
Subjects: subject: Agent-Based Modelling
subject: Information Diffusion
subject: Seeding
subject: Social Networks
subject: Zambia
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: The successful adoption of innovations depends on the provision of adequate information to farmers. In rural areas of developing countries, farmers usually rely on their social networks as an information source. Hence, policy-makers and program-implementers can benefit from social diffusion processes to effectively dis-seminate information. This study aims to identify the set of farmers who initially obtain information (‘seeds’) that optimises diffusion through the network. It systematically evaluates different criteria for seed selection, number of seeds, and their interaction effects. An empirical Agent-Based Model adjusted to a case study in rural Zambia was applied to predict diffusion outcomes for varying seed sets ex ante. Simulations revealed that informing farmers with the most connections leads to highest diffusion speed and reach. Also targeting village heads and farmers with high betweenness centrality, who function as bridges connecting different parts of the network, enhances diffusion. An increased number of seeds improves reach, but the marginal effects of additional seeds decline. Interdependencies between seed set size and selection criteria highlight the importance of considering both seed selection criteria and seed set size for optimising seeding strategies to enhance information diffusion. © 2020, University of Surrey. All rights reserved.
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1
Creators: name: Calabresi, Paolo
name: Kitada, Tohru
name: Costa, Cinzia
name: Martins, Andrea
name: Goldberg, Matthew S.
name: Tscherter, Anne
name: Haburcak, Marian
name: Tong, Youren
name: Bernardi, Giorgio
name: Shen, Jie
name: Martella, Giuseppina
name: Roth, Bryan L.
name: Vortherms, Timothy A.
name: Pisani, Antonio
name: Pothos, Emmanuel N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The manifestations of Parkinson’s disease are caused by reduced dopaminergic innervation of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism. To investigate a possible role for DJ-1 in the dopaminergic system, we generated a mouse model bearing a germline disruption of DJ-1. Although DJ-1−/− mice had normal numbers of dopaminergic neurons in the substantia nigra, evoked dopamine overflow in the striatum was markedly reduced, primarily as a result of increased reuptake. Nigral neurons lacking DJ-1 were less sensitive to the inhibitory effects of D2 autoreceptor stimulation. Corticostriatal long-term potentiation was normal in medium spiny neurons of DJ-1−/− mice, but long-term depression (LTD) was absent. The LTD deficit was reversed by treatment with D2 but not D1 receptor agonists. Furthermore, DJ-1−/− mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions.
The influence of adsorbate interactions on kinetics and equilibrium for CO on Ru(001). I. Adsorption kinetics
Creators: name: Pfnür, Herbert
name: Menzel, D.
Publisher: name: College Park, MD : American Institute of Physics
Year: 1983
Subjects: subject: CO adsorption
subject: chemisorption
subject: precursor model
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: After careful calibration, the work function change induced by CO adsorption on Ru(001) has been used to measure the sticking coefficient s as functions of sample temperature (between 100 and 400 K) and coverage, with the gas temperature always at about 295 K. The main results are: At θ=0, the sticking coefficient is independent of sample temperature between 100 and 400 K, at s0=0.7 for 0<θ<0.2. s drops proportional to (1–θ) for Ts≳200 K, and more gradually below 200 K; at 100 K, s drops slowly up to θ=0.5. Above θ=0.23 a sharp decrease of s sets in for Ts≳120 K; a second plateau becomes obvious around θ∼0.35 for Ts<360 K. Close to saturation, s drops to below 10−2. These results are discussed in terms of a precursor model with strong effects of the chemisorbed layer on the properties of the precursor. A critical evaluation of the formal precursor states involved suggests that classical precursor states exist only at appreciable coverage and are defined by the lateral and vertical interactions, while at low coverage the collisional dynamics are determined for sticking of molecules.
Metformin mediates MicroRNA-21 regulated circulating matrix metalloproteinase-9 in diabetic nephropathy: an in-silico and clinical study
Creators: name: Khokhar, Manoj
name: Roy, Dipayan
name: Bajpai, Nitin Kumar
name: Bohra, Gopal Krishna
name: Yadav, Dharamveer
name: Sharma, Praveen
name: Purohit, Purvi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Hematology

description: Metformin is commonly used as an oral hypoglycaemic agent in type 2 diabetes mellitus (T2DM). MicroRNA-21 is widely studied in diabetic and diabetic nephropathy (DN) patients. Matrix metalloproteinase-9 (MMP9) is involved in extracellular matrix degradation and tissue repair processes. However, the effect of metformin administration on hsa-miR-21-5p and MMP9 has not been evaluated in T2DM and DN patients. The study subjects were divided into three groups (Healthy controls = 36, T2DM = 38, DN = 35). Anthropometric measurements were taken and biochemical tests were carried out on fasting blood samples. Reverse transcriptase PCR was employed for whole blood gene expression analysis of hsa-miR-21-5p and MMP9. Bioinformatics analyses including drug-gene interaction, protein-protein interaction, functional enrichment analyses and co-expression networks were performed. In the present study, MMP9 and hsa-miR-21-5p levels were downregulated and upregulated respectively in T2DM and DN patients when compared with healthy controls. However, in metformin-treated group, a downregulation of hsa-miR-21-5p and upregulation of MMP9 was observed. In-silico analysis revealed the target genes involved in the miR-21 and MMP9 interaction network. Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. MMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population. The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9. In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p. Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p.
Identification of parameters in building concentration dispersion model
Creators: name: Calogine, D.
name: Boyer, H.
name: Ndoumbe, S.
name: Rivière, C.
name: Miranville, F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: The aim of this work is to simulate the pollutants transport in buildings. Focusing mainly on the presence of CO2, firstly we resolve the airflow equations for two typical validation cases, the Rao case and the IEA case. These numerical results are compared to the most known software and they are used to evaluate of the evolution of CO2 concentration in the different rooms. In order to obtain the different parameters and filters of the proposed model we use a statistical method based on Bayesian inference. The final comparison of results is coherent but a complementary experimental procedure is necessary to calibrate and refine the model
title: Der Kreis Saarlouis und seine nächste Umgebung unter den Römer und Celten, von Ph. Schmitt, Trier 1850
Creators: name: Braun, Johann W. J.
Publisher: name: University Library Heidelberg
Year: 2016

description: Der Kreis Saarlouis und seine nächste Umgebung unter den Römer und Celten. Ein Bericht an die Gesellschaft für nützliche Forschungen zu Trier, von Ph. Schmitt, Pfarrer zu St. Paulin bei Trier, wirklichem Mitgliede der Gesellschaft für nützliche Forschungen zu Trier, und correspondirendem der Gesellschaften zu Saarbrücken und Metz. Trier, Linz'sche Buchhandlung 1850. 158 S. 8vo.
New Constraints on the Spin of the Black Hole Cygnus X-1 and the Physical Properties of its Accretion Disk Corona
Creators: name: Krawczynski, H.
name: Beheshtipour, B.
Publisher: name: London : Institute of Physics Publ.
Year: 2022
Subjects: subject: X-Ray Reflection
subject: Polarization Properties
subject: Angular-Distribution
subject: Energy-Spectra
subject: Soft State
subject: Gamma-Ray
subject: Emission
subject: Comptonization
subject: Simulations
subject: Profiles
subject: Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie

description: We present a new analysis of NuSTAR and Suzaku observations of the black hole Cygnus X-1 in the intermediate state. The analysis is performed using kerrC, a new model for analyzing spectral and spectropolarimetric X-ray observations of black holes. kerrC builds on a large library of simulated black holes in X-ray binaries. The model accounts for the X-ray emission from a geometrically thin, optically thick accretion disk, the propagation of the X-rays through the curved black hole spacetime, the reflection off the accretion disk, and the Comptonization of photons in coronae of different 3D shapes and physical properties before and after the reflection. We present the results from using kerrC for the analysis of archival NuSTAR and Suzaku observations taken on 2015 May 27-28. The best wedge-shaped corona gives a better fit than the cone-shaped corona. Although we included cone-shaped coronae in the funnel regions above and below the black hole to resemble to some degree the common assumption of a compact lamppost corona hovering above and/or below the black hole, the fit chooses a very large version of this corona that makes it possible to Comptonize a sufficiently large fraction of the accretion disk photons to explain the observed power-law emission. The analysis indicates a black hole spin parameter a (-1 ≤ a ≤ 1) between 0.861 and 0.921. The kerrC model provides new insights into the radial distribution of the energy flux of returning and coronal emission irradiating the accretion disk. kerrC furthermore predicts small polarization fractions around 1% in the 2-8 keV energy range of the recently launched Imaging X-ray Polarimetry Explorer. © 2022. The Author(s). Published by the American Astronomical Society.
Towards a Graph-Based Approach for Web Services Composition
Creators: name: Mahmoud, Chaker Ben
name: Bettahar, Fathia
name: Abderrahim, Hajer
name: Saidi, Houda
Publisher: name: arXiv
Year: 2013
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Nowadays, Web services (WS) remain a main actor in the implementation of distributed applications. They represent a new promising paradigm for the development, deployment and integration of Internet applications. The aim of Web services composition is to use the skills of several departments to resolve any problem that cannot be solved individually. The result of this composition is a compound of Web services that define how they will be used. In this paper, we propose an approach for automatic web services composition based on the concepts of directed graphs for the representation and description of Web services, and the ordering of web services compound execution. In this context, the user query, defined by a set of inputs and outputs, can be viewed as a directed graph composed of Web services.