cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Commission Basis of Payment Under Marketing Agreement -- NSPE Case No. 78-7
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Research and Practice

description: This is a historical case reviewed by the NSPE Board of Ethical Review in 1978. An engineer, experienced in providing services to the international community, wants to draw on that experience to provide international marketing services to U.S. engineering firms in return for a commission on the services those firms gain as a result of his marketing help.
An $ω$ Deformation of Gauged STU Supergravity
Creators: name: Lu, H.
name: Pang, Y.
name: Pope, C. N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Four-dimensional ${\cal N}=2$ gauged STU supergravity is a consistent truncation of the standard ${\cal N}=8$ gauged $SO(8)$ supergravity in which just the four $U(1)$ gauge fields in the Cartan subgroup of $SO(8)$ are retained. One of these is the graviphoton in the ${\cal N}=2$ supergravity multiplet and the other three lie in three vector multiplets. In this paper we carry out the analogous consistent truncation of the newly-discovered family of $ω$-deformed ${\cal N}=8$ gauged $SO(8)$ supergravities, thereby obtaining a family of $ω$-deformed STU gauged supergravities. Unlike in some other truncations of the deformed ${\cal N}=8$ supergravity that have been considered, here the scalar potential of the deformed STU theory is independent of the $ω$ parameter. However, it enters in the scalar couplings in the gauge-field kinetic terms, and it is non-trivial because of the minimal couplings of the fermion fields to the gauge potentials. We discuss the supersymmetry transformation rules in the $ω$-deformed supergravities, and present some examples of black hole solutions.
description: 31 pages. Derivation of the range of \omega corrected; discussion of supersymmetry of solutions extended, and a reference added
title: Исследование информативности параметров контроля качества тепловых труб
Creators: name: Филипченко, Н.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: В данной работе выполнены исследования по оценке информативности параметров контроля качества тепловых труб. В данной статье рассматривается проблема выбора наиболее информативного из выбранных параметров. Разработаны модели 9 нестационарных тепловых задач в программном обеспечении «Elcut». В ходе исследования были получены графики распределения частот параметров, а также графики изменения параметров во времени.
title: Keynote Address: The Future of Cardiovascular Epidemiology: Current Trends?
Creators: name: Ramachandran, Vasan S.
Publisher: name: eScholarship@UMMS
Year: 2016

description: This is the Research Retreat's Keynote presentation by Vasan S. Ramachandran, MD, who is Principal Investigator and Co-Director, Echocardiography/Vascular Laboratory, Framingham Heart Study. Dr. Ramachandran is also Chief, Section of Preventive Medicine and Epidemiology and Professor of Medicine, Boston University School of Medicine. Dr. Ramachandran discusses the future of cardiovascular epidemiology, including the roles of: cHealth (community), sHealth (social), mHealth (mobile), eHealth (electronic), and gHealth (genomic).
Intimate partner economic abuse in loans and guarantees: An empirical review of 10 years of cases
Creators: name: Thomas, Susan Barkehall
name: Batagol, Becky
name: Ulbrick, Madeleine
Publisher: name: Monash University
Year: 2023
Subjects: Banking, finance and securities law
Private law and civil obligations not elsewhere classified
Family law
Law, gender and sexuality (incl. feminist legal scholarship)
Sociology of gender

description: Economic abuse is a form of family violence that is under-recognised and under-reported. A particular type of economic abuse is debt abuse in relation to joint borrowings for property and the provision of guarantees. The doctrines of unconscionability (both under statute and equity), undue influence, and statutory jurisdictions to set aside ‘unjust contracts’ are key doctrines for a victim who seeks to have a credit contract set aside. This article uses a quantitative and qualitative content analysis of the facts and outcomes of ten years of Australian case law between 2008 and 2018 to examine whether victims of intimate partner debt abuse are obtaining meaningful outcomes using these doctrines. We conclude that in the case of intimate partner debt abuse caused by family violence, the legal system is not able to account for gendered inequalities of bargaining power nor provide adequate remedies. We provide recommendations for reform both at doctrinal level and as part of broader systemic reform.
Continuity of the torsionless limit as a selection rule for gravity theories with torsion
Creators: name: Fabbri, Luca
name: Mannheim, Philip D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: While one can in principle augment gravity theory with torsion, it is generally thought that any such torsion affects would be too small to be of consequence. Here we show that this cannot in general be the case. We show that the limit of vanishing torsion is not necessarily a continuous one, with the theory obtained in the limit not necessarily coinciding with the theory in which torsion had never been present at all. However, for a standard torsion tensor that is antisymmetric in two of its indices we have found two cases in which the vanishing torsion limit is in fact continuous, namely Einstein gravity and conformal gravity. For other gravity theories of common interest to possess a continuous limit the torsion tensor would need to be antisymmetric in all three of its indices.
description: 6 pages, revtex4. Final version, to appear in Phys. Rev. D
Constraining axion-nucleon coupling constants from measurements of effective Casimir pressure by means of micromachined oscillator
Creators: name: Bezerra, V. B.
name: Klimchitskaya, G. L.
name: Mostepanenko, V. M.
name: Romero, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Stronger constraints on the pseudoscalar coupling constants of an axion to a proton and a neutron are obtained from an indirect measurement of the effective Casimir pressure between two Au-coated plates by means of micromechanical torsional oscillator. For this purpose, the additional effective pressure due to two-axion exchange is calculated. The role of boundary effects and the validity region of the proximity force approximation in application to forces of axion origin are determined. The obtained constraints are up to factors of 380 and 3.15 stronger than those found recently from other laboratory experiments and are relevant to axion masses from $10^{-3}$eV to 15eV.
description: 8 pages, 2 figures, 2 tables; several additions have been made in accordance with version accepted for publication in Eur. Phys. J. C
Patent Authorship: Whose DNA Is It Anyway?
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Authorship
Collaboration
Mentors and Trainees
Publication Ethics
Research and Practice

description: This case highlights potential dilemmas encountered by postdoctoral fellows in a research setting. Who owns the patent when a project belongs to both a faculty member and a graduate student? It also looks at potential conflicts between students and faculty when research and manuscript ownership are not clearly specified.
A Heterotic Standard Model with B-L Symmetry and a Stable Proton
Creators: name: Buchbinder, Evgeny I.
name: Constantin, Andrei
name: Lukas, Andre
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider heterotic Calabi-Yau compactifications with S(U(4)xU(1)) background gauge fields. These models lead to gauge groups with an additional U(1) factor which, under certain conditions, can combine with hypercharge to a B-L symmetry. The associated gauge boson is automatically super-massive and, hence, does not constitute a phenomenological problem. We illustrate this class of compactifications with a model based on the monad construction, which leads to a supersymmetric standard model with three families of quarks and leptons, one pair of Higgs doublets, three right-handed neutrinos and no exotics charged under the standard model group. The presence of the B-L symmetry means that the model is safe from proton decay induced by dimension four operators. Due to the presence of a special locus in moduli space where the bundle structure group is Abelian and the low-energy symmetry enhances we can also show the absence of dimension five proton-decay inducing operators.
description: 23 pages Latex
title: Poster Session Program: 2016 UMass Center for Clinical and Translational Science Research Retreat
Creators: name: UMCCTS Research Retreat
Publisher: name: eScholarship@UMMS
Year: 2016

description: Poster Session Program for the 6th annual UMass Center for Clinical and Translational Science Research Retreat, held Friday, May 20, 2016 at the University of Massachusetts Medical School, Worcester, MA.
Nonequilibrium distribution functions for quantum transport: universality and approximation for the steady state regime
Creators: name: Ness, H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive a general expression for the electron nonequilibrium (NE) distribution function in the context of steady state quantum transport through a two-terminal nanodevice with interaction. The central idea for the use of NE distributions for open quantum systems is that both the NE and many-body (MB) effects are taken into account in the statistics of the finite size system connected to reservoirs. We develop an alternative scheme to calculate the NE steady state properties of such systems. The method, using NE distribution and spectral functions, presents several advantages, and is equivalent to conventional steady-state NE Green's functions (NEGF) calculations when the same level of approximation for the MB interaction is used. The advantages of our method resides in the fact that the NE distribution and spectral functions have better analytic behaviour for numerical calculations. Furthermore our approach offer the possibility of introducing further approximations, not only at the level of the MB interaction as in NEGF, but also at the level of the functional form used for the NE distributions. For the single level model with electron-phonon coupling we have considered, such approximations provide a good representation of the exact results, for either the NE distributions themselves or the transport properties. We also derive the formal extensions of our method for systems consisting of several electronic levels and several vibration modes.
description: paper accepted for publication in Phys. Rev. B (fig 4 now correct)
title: UMass Center for Clinical and Translational Science: Past, Present and Future
Creators: name: Luzuriaga, Katherine
Publisher: name: eScholarship@UMMS
Year: 2016

description: Katherine Luzuriaga, MD, is PI and Director, UMass Center for Clinical and Translational Science and Vice Provost, Clinical and Translational Research at UMass Medical School. Dr. Luzuriaga is also the UMass Memorial Health Care Chair in Biomedical Research and Professor, Program in Molecular Medicine, Pediatrics and Medicine. In her presentation, she reviews the history, goals, programs and achievements of the UMass Center for Clinical and Translational Science.
title: Medical, Social, and Other Determinants of Health Care Costs in MassHealth
Creators: name: Ash, Arlene S.
Publisher: name: eScholarship@UMMS
Year: 2016

description: As part of the mini-symposium entitled "Innovations for Vulnerable Populations in Massachusetts," this presentation explores research into expanding the State’s existing risk models to include social determinants of health variables. Potential variables for inclusion in payment models (such as unstable housing, defined as having three or more addresses during a calendar year) have been identified. These models are being developed in support of alternative payment mechanisms for integrated delivery systems.
title: The BCH-SBPR: A Multi-disciplinary Registry Collecting Longitudinal Data on Patients with Spina Bifida
Creators: name: Alkawaldeh, Mohammad
name: Sherlock, Rebecca
name: Carlos, Estrada
name: Alkhawaldeh, Erika
Publisher: name: eScholarship@UMMS
Year: 2017

description: Introduction. In the U.S. alone, approximately 1500 infants are born with SB each year. An estimated 166,000 individuals with SB live in the United States.

Background. The BCH-SBPR was established in August 2015 to help increase knowledge about new procedures, surgeries and treatment options, growing up with Spina Bifida, and to guide healthcare practices by prospectively studying a cohort of children born with this condition.

Objective. The objective of this project is to collect comprehensive longitudinal clinical data (demographics, treatments, and outcomes) from a multi- disciplinary clinic on patients with SB.

Design: Prospective longitudinal design. Data collection will occur every six months.

Methods. Study subjects include children whose ages range from birth to 35 years with one of the following six SB diagnoses: Myelomeningocele, Meningocele, Lipoma of Spinal Cord, Fatty Thickened Filum, Split Cord Malformation, and Terminal Myelocystocele will be eligible to participate.

Results. 653 patients were enrolled in this registry. 635 patients were enrolled in this registry. 66 patients were randomly selected to conduct a descriptive analysis. The mean age was 9.7 (7.63 SD). The majority of the patients' age were between 5 and 13 years old (40 %). The female participants (58.3 % ) were slightly more than male participants (41.7%). The majority was white (56.7%) and None-Hispanic or Latino. 40% of the patient relaid on public insurance. 70% had an MMC and 30 non-MMC diagnoses. The majority of the patients were geographically located in Massachusetts (63.2.%). Therefore, further analysis of descriptive and inferential statistics will be conducted early August 2017.

Conclusion. This Registry will provide valuable longitudinal clinical data from approximately 700 patients with SB conditions. The collected data will be used for quality improvement and research projects.
title: The Effectiveness of Tablet-based Application for Older Adults with Diabetes Mellitus Type II: A Pilot Study
Creators: name: Alkawaldeh, Mohammad
name: Cynthia, Jacelon
name: Choi, Jeungok
name: Marquard, Jenna
name: Ridgway, John
Publisher: name: eScholarship@UMMS
Year: 2017

description: Introduction: Advances in technological applications such as tablet-based computers is growing dramatically in the field of healthcare, as there is a considerable eagerness for mobile health interventions. Tablet-based interventions can have positive effects on both health and health service delivery processes (Free et al, 2013). Technological applications have been developed for a wide range of healthcare needs, including patient registration, data management, and self- management applications.

Background: The usefulness of technology and the powerful capabilities of technological applications have led to a significantly increased interest in finding novel approaches to support older adults’ self-management.Self-management technological applications have been used in various contexts, and usability is key in sustainability and adoption of such technologies.

Theoretical Framework: The study will be guided by the self-management model of Maintaining the Balance (Jacelon, 2010).

Design: Quasi-experimental design.

Methods: Quantitative standardized measures will be used in this study. A purposive sample of 24 elderly patients with DMII will be recruited for the study. The descriptive and inferential analysis will be used to analyze the quantitative data.

Results: This is an ongoing project, and the study is currently in the recruitment and data collection phase.The final patient is expected to be enrolled by the end of March 2017. We hope to recruit approximately 24 patients to the study. Analyses will focus on usability attributes (effectiveness, efficacy, errors/simplicity, and overall satisfaction), perceived diabetes self-management and blood glucose level are the main outcomes.

Conclusion: A well-designed application with new features has the ability to provide more promising results regarding improving the quality of life, supporting informed decision making, improving communication with care providers, promoting active collaboration with care teams, encouraging self-care behaviors, problem-solving, improving health status, and improving clinical outcomes.
Entangling Power of Disordered Quantum Walks
Creators: name: Vieira, Rafael
name: Amorim, Edgard P. M.
name: Rigolin, Gustavo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We investigate how the introduction of different types of disorder affects the generation of entanglement between the internal (spin) and external (position) degrees of freedom in one-dimensional quantum random walks (QRW). Disorder is modeled by adding another random feature to QRW, i.e., the quantum coin that drives the system's evolution is randomly chosen at each position and/or at each time step, giving rise to either dynamic, fluctuating, or static disorder. The first one is position-independent, with every lattice site having the same coin at a given time, the second has time and position dependent randomness, while the third one is time-independent. We show for several levels of disorder that dynamic disorder is the most powerful entanglement generator, followed closely by fluctuating disorder. Static disorder is the less efficient entangler, being almost always less efficient than the ordered case. Also, dynamic and fluctuating disorder lead to maximally entangled states asymptotically in time for any initial condition while static disorder has no asymptotic limit and, similarly to the ordered case, has a long time behavior highly sensitive to the initial conditions.
description: v1: 11 pages, 16 figures, two columns, RevTex4; v2: published version
Much Obliged
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Collaboration
Ethics and Society
Grant Management
Intellectual Property and Patents
Mentors and Trainees
Research and Practice
Social Responsibility

description: This case highlights potential dilemmas encountered by postdoctoral fellows in a research setting. To whom is a research Ph.D. student obligated when a patent for research he created will be owned by the university and hinder his own future research? It also explores the ethics of conflicting commitments and obligations that arise with successful research.
A Systematic Review of School-involvement in Wraparound Care for Youth with Mental and Behavioral Health Difficulties
Creators: name: Kim, Jiwon
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Education Policy
subject: Disability and Equity in Education
subject: Public Affairs, Public Policy and Public Administration
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Health Policy
subject: Education
subject: School Psychology

description: Much research regarding youth with mental or behavioral health difficulties calls for comprehensive services that address physical, emotional, social, as well as educational needs. Wraparound approaches emerged in the 1980s as a framework for providing quality mental health services. Although research has identified that wraparound initiatives can have a positive effect on general school functioning, and schools have been involved in various systems of care initiatives, there is yet to have been a study to systematically review those efforts with a primary focus on educational outcomes, or identify what role schools and school-based professionals play in modes of coordinated service delivery. This study seeks to investigate what short- and long-term psychoeducational outcomes wraparound approaches have been found to be associated with, and to what extent schools or educational systems were involved in those approaches.
title: Broad Repertoire of T Cell Autoreactivity Directly from Islets of Donors with Type 1 Diabetes (T1D)
Creators: name: Babon, Jenny Aurielle B.
name: DeNicola, Megan E.
name: Blodgett, David M.
name: Crevecoeur, Inne
name: Buttrick, Thomas S.
name: Maehr, Rene
name: Bottino, Rita
name: Naji, Ali
name: Kaddis, John
name: Elyaman, Wassim
name: James, Eddie A.
name: Haliyur, Rachana
name: Brissova, Marcela
name: Overburgh, Lut
name: Mathieu, Chantal
name: Delong, Thomas
name: Haskins, Kathryn
name: Pugliese, Alberto
name: Campbell-Thompson, Martha
name: Mathews, Clayton
name: Atkinson, Mark A.
name: Powers, Alvin C.
name: Harlan, David
name: Kent, Sally C.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Type 1 diabetes (T1D) is an autoimmune disease characterized by the infiltration of lymphocytes into the insulin-producing β-cells in the pancreas. We have isolated live T cells sorted or grown directly from the isolated, handpicked islets of human donors with T1D. We received ~500 islet equivalent EQ of variable purity (10-90%) from 12 donors with T1D (disease duration 0.42-20 years) and from seven control donors and two donors with type 2 diabetes (T2D). A total of 321 T cell lines and clones were derived from the islets of donors with T1D (3 lines from the 9 control donors). These are 131 CD4+ lines and clones, 47 CD8+ lines and 143 lines that contain both CD4+ and CD8+ T cells. From 50 lines and clones examined to date, we have determined the autoreactivity of 19 and have seen a broad repertoire of T cell autoreactivity in the islets, including characterized targets and post-translationally modified targets. Autoreactivity of CD4+ T cell lines was to three different peptides from glutamic acid decarboxylase 65 (GAD; GAD115-127, GAD274-286, GAD555-567), proinsulin76-90, and to chromogranin A or proinsulin expressed by DR4+DQ8+ B cells transduced with lentivirus containing constructs with the open reading frames corresponding to whole autoantigens. Reactivity to modified peptides included the glucose-regulated protein 78 and islet amyloid polypeptide with arginine to citrulline modifications (GRP78292-305(Arg-Cit297) and IAPP65-84(Arg-Cit 73, 81)), deaminations (IA-2545-562(Gln-Glu 548, 551, 556), and to several insulin hybrid peptides. These autoreactive CD4+ T cell lines and clones secreted only pro-inflammatory cytokines (IFN-γ, TNFα) upon peptide stimulation. For CD8+ T cells from islets, from one donor with T1D, we saw binding of a pool of HLA-A2 pentamers loaded with insulin B10-18, IA-2797-805 and insulin specific glucose-6-phosphatase catalytic subunit related protein, IGRP265-273. These results have implications for the development of successful prevention and reversal therapeutic strategies in T1D.
title: The Effects of Early Adoption of Academic Electronic Health Records System (EHRS) on Patient Outcome in Nursing
Creators: name: Chung, Joohyun
name: Yan, Donghui
name: Davis, Gray
Publisher: name: eScholarship@UMMS
Year: 2017

description: The wide adoption of EHR systems has led the Institute of Medicine (IOM) to emphasize the use of informatics as a core competency required of all health care professions. However, the nursing profession has been slow to incorporate information technology into formal nurse education and practice. In the massive transformation from disconnected, inefficient, paper-based care delivery to interconnected system driven by EHRs (Electronic Health Records system), little is known about the effect of the early adoption of academic EHRs in nursing education and relationship between effective use of EHRs and patient outcome in nursing.

In this study, a community-academic partnership was driven to have better resources to assess the effect of the early adoption of academic EHRs in Nursing education, using the local hospital’s training set of electronic health records system (EHRs). With this pilot study, a quantitative research design with supportive qualitative research will be used. First a two-group quasi-experimental pre-post design will be used to assess changes in nursing students’ readiness/effectiveness of nursing documentation using academic EHRs. Second, a cross-sectional research design will be used to identify the relationship between effectiveness of nursing documentation by nurses (e.g., time) and patient outcome (e.g., incident rate, healthcare associated infections, falls incidences, pressure ulcer incidences, and patient satisfaction). Student and faculty participants will be recruited from one university in the Eastern United States. Nurse participants will be recruited from one hospital in Eastern United States. Patient outcome information will be retrieved from the electronic health record system.

These findings will be very helpful to prepare students for the future of health information technology. Meaningful adoption of academic electronic health record systems will help in building the undergraduate nursing students’ competence in nursing documentation with electronic health record systems and improve patient care.
title: Trends in Cause of Death among Puerto Rican and United States Multiple Myeloma Patients
Creators: name: Castaneda-Avila, Maira
name: Ortiz-Ortiz, K. J.
name: Torres-Cintrón, C. R.
name: Epstein, Mara M.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background/Objective: Multiple myeloma (MM) is an incurable, yet treatable, cancer of plasma cells. Due to recent improvements in treatment, people diagnosed with MM have been living longer, and other co-morbid conditions may be of increasing importance. This study examines temporal trends in specific causes of death among MM patients in Puerto Rico (PR) and United States (US).

Methods: We analyzed primary cause of death among all incident MM cancer cases recorded in the Puerto Rico Central Cancer Registry (PRCCR) (n=3,018) and the US Surveillance, Epidemiology, and End Results Program (SEER) (n=67,733) between 1987-2013, overall and by follow-up time, age, and sex. We calculated the cumulative incidence of death due to seven selected causes and analyzed age-adjusted mortality trends by MM and other causes using joinpoint regression.

Results: MM accounted for 71.7% and 71.3% of all reported deaths in PR and US, respectively, among people diagnosed with MM. In PR, the proportion of patients that died from MM decreased with increasing follow-up time since diagnosis (72.3% of deaths with ≤2 years vs 65.6% with >5 years of follow-up) and the proportion of patients who died from circulatory (4.6% vs 9.0%) and respiratory system (3.7% vs 5.0%) diseases increased slightly. A similar trend of decreasing MM deaths with follow-up time was observed in the US (73.2% of deaths with ≤2 years vs 66.5% with >5 years of follow-up). Joinpoint regression showed a decreasing trend in MM mortality in the US (APC1987-2007=-2.8%, and APC2007-2013=-18.4%) and a similar, though somewhat weaker, trend in PR (APC1987-2013=-2.73).

Conclusion: In both PR and the US, people diagnosed with MM are still more likely to die from MM than from another cause. However, a decrease in MM mortality is evident, particularly in more recent years, but this decrease is lower in Puerto Rico.
YANGI BOSQICHGA CHIQGAN O'ZBEKISTON VA QATAR HAMKORLIGI: IKKI TOMON UCHUN MANFAATLAR VA VAZIFALAR
Creators: name: Norbekov, Fayzullo
Publisher: name: Zenodo
Year: 2023

description: Har bir rivojlangan va rivojlanayotgan mamlakatlar tashqi siyosatda ko'proq davlat bilan diplomatik va iqtisodiy munosabat o'rnatishga harakat qiladi. Xususan, keyingi davrda O'zbekiston Respublikasining arab davlatlari bilan aloqalari sezilarli darajad rivojlandi. Shu o'rinda, davlatimizning Qatar davlati bilan aloqalariga nazar tashlaylik. Ham iqtisodiy, ham siyosiy, ham diplomatik, ham logistic aloqalarni o'rnatgan bu ikki davlat o'rtasida ikki taraf uchun bir qancha manfaatlar mavjud. Ushbu tezis O'zbekiston va Qatar hamkorligidagi manfaatlar va ikki taraf uchun qilinishi kerak bo'lgan vazifa va ishlarni ko'rib chiqadi.
A quantitative improvement for Roth's theorem on arithmetic progressions
Creators: name: Bloom, Thomas F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We improve the quantitative estimate for Roth's theorem on three-term arithmetic progressions, showing that if $A\subset\{1,\ldots,N\}$ contains no non-trivial three-term arithmetic progressions then $\lvert A\rvert\ll N(\log\log N)^4/\log N$. By the same method we also improve the bounds in the analogous problem over $\mathbb{F}_q[t]$ and for the problem of finding long arithmetic progressions in a sumset.
Self-force on a charge outside a five-dimensional black hole
Creators: name: Beach, Matthew J. S.
name: Poisson, Eric
name: Nickel, Bernhard G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We compute the electromagnetic self-force acting on a charged particle held in place at a fixed position r outside a five-dimensional black hole described by the Schwarzschild-Tangherlini metric. Using a spherical-harmonic decomposition of the electrostatic potential and a regularization prescription based on the Hadamard Green's function, we express the self-force as a convergent mode sum. The self-force is first evaluated numerically, and next presented as an analytical expansion in powers of R/r, with R denoting the event-horizon radius. The power series is then summed to yield a closed-form expression. Unlike its four-dimensional version, the self-force features a dependence on a regularization parameter s that can be interpreted as the particle's radius. The self-force is repulsive at large distances, and its behavior is related to a model according to which the force results from a gravitational interaction between the black hole and the distribution of electrostatic field energy attached to the particle. The model, however, is shown to become inadequate as r becomes comparable to R, where the self-force changes sign and becomes attractive. We also calculate the self-force acting on a particle with a scalar charge, which we find to be everywhere attractive. This is to be contrasted with its four-dimensional counterpart, which vanishes at any r.
description: 26 pages, 2 figures. Major changes from previous version: the regularization procedure is now fully justified, and the singular field is shown to make a contribution to the self-force
title: Impact of Body Mass Index and Weight Change on Risk of Recurrence in Patients Treated for Endometrial Adenocarcinoma
Creators: name: DeGregorio, Geneva A.
name: Leung, Katherine
name: Bradford, Leslie S.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: Obesity is a well-documented risk factor for EAC, but the relationship between obesity and disease recurrence is controversial. Additionally, body weight is an inherently dynamic variable and no studies have examined the relationship between interval weight change and risk of EAC recurrence.

Objectives: To identify if there is a relationship between body mass index (BMI) or interval weight change and the risk of disease recurrence among women treated for EAC.

Methods: We conducted a retrospective chart review of 337 women diagnosed and treated surgically for EAC at UMass Memorial Medical Center from 2010 to 2015. The effect of BMI on risk of disease recurrence was assessed by Cox proportional hazards model adjusting for age, FIGO stage, myometrial invasion, lymphovascular space involvement and status of adjuvant therapy. The effect of interval weight change on EAC recurrence was assessed using logistic regression, adjusting for BMI and recurrence free interval.

Results: Among 337 women diagnosed with EAC, mean BMI at diagnosis was 35.9 pounds (SD: 8.9), mean weight at diagnosis was 201.5 pounds (SD: 52.7) and mean interval weight change was -8.1 pounds (SD: 18.8). At time of data extraction there were 19 patients (5.7%) with disease recurrence. The hazard ratio for recurrence in women with BMI >50 was 11.4 [95%CI: 1.54-84.05] times that of women with BMI<30 >(p=0.02). Women who maintained or gained weight following primary surgical resection had no increased risk of recurrence compared to those who lost weight [OR: 1.02, 95%CI: 0.27-3.82] (p=0.97).

Conclusion: Women with extreme obesity at diagnosis are more likely to have disease recurrence following primary surgical treatment for endometrial adenocarcinoma. However, women who lose weight following primary surgical treatment of EAC are just as likely to have disease recurrence as those who maintain or gain weight.
Reflections on Gibbs: From Statistical Physics to the Amistad
Creators: name: Kadanoff, Leo P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: This note is based upon a talk given at a celebration in Austin Texas of the achievements of J. Willard Gibbs. J. Willard Gibbs, the younger, was the first American physical sciences theorist. He was one of the inventors of statistical physics. He introduced and developed the concepts of phase space, phase transitions, and thermodynamic surfaces in a remarkably correct and elegant manner. These three concepts form the basis of different areas of physics. The connection among these areas has been a subject of deep reflection from Gibbs' time to our own. This talk therefore tries to celebrate Gibbs by talking about modern ideas about how different parts of physics fit together. At the end of the talk, I shall get to a more personal note. Our own J. Willard Gibbs had all his achievements concentrated in science. His father, also J. Willard Gibbs, also a Professor at Yale, had one great achievement that remains unmatched in our day. I shall describe it.
description: This work was originally given as a talk in 2003 in Austin, Texas. It has now been updated in a manner aimed at publication
title: Gastrointestinal Perforations: Examining the Overlooked Unintentional Consequences of Our Nation’s Epidemic of Antibiotic Exposure
Creators: name: Daniel, Vijaya T.
name: Sanders, Stacy B.
name: Ayturk, M. Didem
name: McCormick, Beth A.
name: Santry, Heena P.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Objective: More than 266 million courses of antibiotics are dispensed to outpatients annually in the US, with the rising elderly population consuming a substantial number of antibiotics. At least 30% of these antibiotics prescribed are unnecessary. Alterations in gut microbiome are known to cause stomach and small intestine (SSI) perforations. However, the impact of antibiotic exposure outcomes of SSI perforations among the elderly has not been studied. We examined the relationship between antibiotic exposure, as a proxy for microbiome modulation, and SSI perforation outcomes in a nationwide sample of elderly patients.

Methods: A 5% random sample of Medicare beneficiaries (2009-2011) was queried to identify patients with SSI perforations. Previous outpatient antibiotic exposure (0-30, 31-60, 61-90 days prior to admission) was assessed. Clinical characteristics were compared between no previous antibiotic exposure (NPA) and previous antibiotic exposure (PA) patients. Primary outcome was in-hospital mortality. Secondary outcomes included length of stay and 30-day readmission. Univariate and multivariable regression analyses were performed.

Results: Overall, 401 patients ≥ 65 years had SSI perforations (68.3% with NPA and 31.7 % with PA). Mean age (± SD) was 80 years (± 8). Overall in-hospital mortality was 13%. There was a significant difference in the rates of mortality (12% in NPA vs. 18 % in 0-30 days PA, 17% 31-60 days PA, and 8% 61-90 days PA, P= 0.002). After adjustment of other factors, a trend toward increased in-hospital mortality was observed among patients in 0-30 days PA (odds ratio [OR] 2.0, 95% confidence interval [CI] (0.9, 4.7) and was significantly associated with ICU admission (OR 4.3, 95% CI (1.8, 10.2).

Conclusion: Recent antibiotic use increases illness severity and may increase mortality among elderly patients with SSI perforations. Exposure to antibiotics, one of the most modifiable determinants of microbiota, should be minimized in the outpatient setting.
title: Sulforaphane Treatment of Children with Autism Spectrum Disorder – A Progress Report
Creators: name: Diggins, Eileen
name: Zimmerman, Andrew
name: Singh, Kanwaljit
name: Connors, Susan
Publisher: name: eScholarship@UMMS
Year: 2017

description: This ongoing clinical trial in autism spectrum disorder (ASD) tests a nontoxic approach to therapy of ASD.

Background: Direct treatment of underlying mechanisms in ASD is limited. Cellular dysfunction in ASD may involve a number of related metabolic pathways. The “fever effect” in ASD, in which febrile illness dramatically but temporarily ameliorates disordered behavior, offers a clinical clue. Fever stimulates heat shock proteins (HSP) and cellular stress responses that may ultimately lead to improved synaptic function and increased long-range connectivity. The expression of gene transcription by NFE2L2 (Nrf2), which is reduced in ASD, may also increase during fever. Sulforaphane (SF), an isothiocyanate obtained from 3-day-old broccoli sprouts, induces HSP and Nrf2 as well as “cell-protective” responses. SF has several possible modes of action that may benefit ASD through common cellular mechanisms underlying heterogeneous phenotypes. SF crosses the blood-brain barrier and is bioavailable orally.

Preliminary data: In a randomized, double-blind, placebo-controlled pilot trial in 44 male adolescents and adults (13-30 years), results showed SF was well tolerated without significant side effects. On average, participants on SF (particularly those with a history of fever effect) showed significantly more improvements in ASD symptoms – including social interaction, aberrant/abnormal behavior, repetitive/stereotypical behavior, and verbal communication – than placebo participants.

Current study: Our randomized, double-blind, placebo-controlled phase-2 clinical trial at UMass has three aims: To determine: (1) if orally administered SF has measurable effects in children (ages 3-12 years) with ASD; (2) if treatment with sulforaphane is safe and well tolerated; (3) To elucidate cellular biomarkers that support the mechanisms of action of SF in ASD. We hypothesize that positive effects of SF will be more marked and lasting in the developing brain. To date, 7 participants have completed the trial, and 22 are actively enrolled. Recruitment is ongoing, with a target sample size of 50.
Behaviorally Typed State Machines in TypeScript for Heterogeneous Swarms
Creators: name: Kuhn, Roland
name: Darmasaputra, Alan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: A heterogeneous swarm system is a distributed system where participants come and go, communication topology may change at any time, data replication is asynchronous and partial, and local agents behave differently between nodes. These systems are hard to design and reason about, mainly because we desire a particular class of behaviors to emerge from the interplay of heterogeneous individual agents. Nevertheless, mission-critical operations like manufacturing process orchestration in factories use such systems due to their uncompromising availability and resilience of computing services. This paper presents a set of TypeScript libraries to model peer-to-peer workflows as state machines, execute them using the Actyx middleware, and check the shape of these machines for conformance to a swarm protocol. The swarm protocol describes an idealized global view of the cooperation of machines of different roles. It directly corresponds to a diagram a product manager would sketch on a whiteboard; this allows for verifying that the coded state machines correctly implement the product specification. A well-formed swarm protocol also guarantees that conforming machines will achieve eventual consensus on the overall state progression even in the absence of further coordination. This tool is for developers of business logic for heterogeneous swarm systems, helping them verify that their protocols and implementations are correct. Tool repo: https://github.com/Actyx/machines
The nuclear matter equation of state with consistent two- and three-body perturbative chiral interactions
Creators: name: Coraggio, L.
name: Holt, J. W.
name: Itaco, N.
name: Machleidt, R.
name: Marcucci, L. E.
name: Sammarruca, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We compute the energy per particle of infinite symmetric nuclear matter from chiral N3LO (next-to-next-to-next-to-leading order) two-body potentials plus N2LO three-body forces. The low-energy constants of the chiral three-nucleon force that cannot be constrained by two-body observables are fitted to reproduce the triton binding energy and the 3H-3He Gamow-Teller transition matrix element. In this way, the saturation properties of nuclear matter are reproduced in a parameter-free approach. The equation of state is computed up to third order in many-body perturbation theory, with special emphasis on the role of the third-order particle-hole diagram. The dependence of these results on the cutoff scale and regulator function is studied. We find that the inclusion of three-nucleon forces consistent with the applied two-nucleon interaction leads to a reduced dependence on the choice of the regulator only for lower values of the cutoff.
description: 9 pages, 12 figures, 3 tables, to be published in Physical Review C. arXiv admin note: text overlap with arXiv:1209.5537
title: C1QBP Inhibits DUX4-Dependent Gene Activation and Can Be Targeted with 4MU
Creators: name: DeSimone, Alec M.
name: Bibat, Genila
name: Wagner, Kathryn
name: Stadler, Guido
name: Wright, Woodring E.
name: Leszyk, John D.
name: Emerson Jr., Charles P.
Publisher: name: eScholarship@UMMS
Year: 2017

description: FSHD is linked to the misexpression of the DUX4 gene contained within the D4Z4 repeat array on chromosome 4. The gene encodes the DUX4 protein, a cytotoxic transcription factor that presumably causes the symptoms of the disease. However, individuals have been identified who express DUX4 in their muscle biopsies, but who remain asymptomatic, suggesting that there are other factors that modify FSHD penetrance or severity. We hypothesized that an FSHD-modifying factor would physically interact with DUX4, and we took a proteomic approach to identify DUX4-interacting proteins. We identified the multifunctional C1QBP protein as one such factor. C1QBP is known to regulate several processes that DUX4 affects, including gene expression, oxidative stress, apoptosis, and pre-mRNA splicing. We used siC1QBP knockdown assays to determine if C1QBP affects DUX4 activity. While C1QBP had little effect on DUX4 activity in myotubes, we found that it inhibits the kinetics of DUX4-target gene activation during myogenic differentiation. This identifies C1QBP as a regulator of DUX4 activity and a potential target for FSHD therapeutics. Importantly, C1QBP is regulated by binding to the signaling molecule hyaluronic acid (HA). Decreasing HA by treating cells with 4-methylumbelliferone (4MU), an inhibitor of HA synthesis, resulted in a sharp decline in DUX4 activity and also greatly reduced its cytotoxicity. We have found that DUX4-induced cytotoxicity is associated with severe mislocalizaton of C1QBP, which is prevented by 4MU. This defect is not a downstream result of DUX4-induced oxidative stress, as it could not be prevented by treating cells with an antioxidant, nor could it be recapitulated by exposing cells to oxidants. This identifies C1QBP as a target for the treatment of FSHD, and in particular indicates that 4MU, already an approved drug in Europe and currently under investigation for other indications, may be an effective C1QBP-targeting FSHD therapeutic compound.
A pHish Tale
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Collaboration
Communicating Science and Engineering
Conflict of Interest
Environmental Justice
Ethics and Society
Mentors and Trainees
Public Well-being
Research and Practice
Social and Political Conflict
Social Responsibility
Sustainability
Sustainable Development

description: This case highlights potential dilemmas encountered by postdoctoral fellows in a research setting. Should a scientist release incomplete data to an environmental group so they may work to prevent further environmental damage, or hope for the best during the five-year EPA funded project that will provide conclusive data? It also explores scientists social responsibilities and public perception of scientific data.
Linking the BICEP2 result and the hemispherical power asymmetry through spatial variation of $r$
Creators: name: Chluba, Jens
name: Dai, Liang
name: Jeong, Donghui
name: Kamionkowski, Marc
name: Yoho, Amanda
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: For the simplest inflation models, the recent detection of a large primordial B-mode polarization signal by the BICEP2 experiment indicates a slight tension with the upper limit on the tensor-to-scalar ratio, $r$, from the Planck satellite. Here, we discuss spatially varying $r$ as a possible explanation for this discrepancy. This idea seems attractive since it may also explain part of the hemispherical temperature power asymmetry seen by WMAP and Planck at large angular scales. If these two aspects are indeed connected, the model suggests that in the Northern hemisphere $r$ should be much smaller, a hypothesis that could be confirmed with future B-mode experiments, providing a test for the stationarity of primordial tensor contributions across the sky. The BICEP2 measurement furthermore rules out that a simple dipolar modulation of $r$ alone can be responsible for the full hemispherical power asymmetry.
description: 3+epsilon pages, 1 figure, accepted by MNRAS
On the Laplace transform of the Fréchet distribution
Creators: name: Penson, K. A.
name: Górska, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: We calculate exactly the Laplace transform of the Fréchet distribution in the form $γx^{-(1+γ)} \exp(-x^{-γ})$, $γ> 0$, $0 \leq x < \infty$, for arbitrary rational values of the shape parameter $γ$, i.e. for $γ= l/k$ with $l, k = 1,2, \ldots$. The method employs the inverse Mellin transform. The closed form expressions are obtained in terms of Meijer G functions and their graphical illustrations are provided. A rescaled Fréchet distribution serves as a kernel of Fréchet integral transform. It turns out that the Fréchet transform of one-sided Lévy law reproduces the Fréchet distribution.
description: 10 pages, 4 figures; one reference added