cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evidence for Cytotoxicity and Mitochondrial Dysfunction in Human Lung Cells Exposed to Biomass Burning Aerosol Constituents: Levoglucosan and 4-Nitrocatechol
Creators: name: Khan, Faria
name: Rudzinski, Krzysztof
name: Kwapiszewska, Karina
name: Szmigielski, Rafal
name: Romero, Alicia M.
name: Surratt, Jason D.
name: Gil-Casanova, Domingo
Publisher: name: Elsevier
Year: 2024

description: Biomass burning (BB) emissions are one of the largest sources of carbonaceous aerosol, posing a significant risk as an airway irritant. Important BB markers include wood pyrolysis emissions, such as levoglucosan (LG) that is an anhydrous sugar bearing a six-carbon ring structure (i.e., 1,6-anhydro-β-D-glucopyranose). Atmospheric chemical aging of BB-derived aerosol (BBA) in the presence of nitrogen oxides (NOx) can yield nitro-aromatic compounds, including 4-nitrocatechol (4NC). There is building evidence that NOx-mediated chemical aging of BBA poses a more serious exposure effect than primary pyrolysis emissions. This study provides a comparative toxicological assessment following the exposure to important BBA marker compounds in human lung cells (i.e., A549 and BEAS-2B) to determine whether aromatic 4NC is more toxic than BBA-bound anhydrous carbohydrate (i.e., LG). We determined inhibitory concentration-50 (IC50) and examined reactive oxygen species (ROS) changes, mitochondrial dysfunction, and apoptosis induction in the two cell lines following exposure to LG and 4NC in a dose-response manner. In the BEAS-2B cells, estimated IC50 values for 4NC were 33 and 8.8 μg mL-1, and for LG were 2546 and ∼ 3 × 107 μg mL-1 at 24 h and 48 h of exposure, respectively. A549 cells exhibited a much higher IC50 value than BEAS-2B cells. LG exposures resulted in mitochondrial stress with viability inhibition, but cells recovered with increasing exposure time. 4NC exposures at 200 μg mL-1 resulted in the induction of apoptosis at 6 h. Mitochondrial dysfunction and ROS imbalance induced the intrinsic apoptotic pathway induction following 4NC exposures. While increased ROS is caused by LG exposure in lung cells, 4NC is a marker of concern during BB emissions, as we observed apoptosis and high mitochondrial ROS in both lung cells at atmospherically-relevant aerosol concentrations. It may be associated with higher airway or inhalation pathologies in higher BBA emissions, such as wildfires or during wood combustion.
Heterogeneity-aware integrative regression for ancestry-specific association studies
Creators: name: Cai, Yanwei
name: Kooperberg, Charles
name: Hsu, Li
name: Molstad, Aaron J
name: Reiner, Alexander P
name: Sun, Wei
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral groups. These studies require ancestry-specific models for protein expression as a function of SNP genotypes. In order to improve protein expression prediction in ancestral populations historically underrepresented in genomic studies, we propose a new penalized maximum likelihood estimator for fitting ancestry-specific joint protein quantitative trait loci models. Our estimator borrows information across ancestral groups, while simultaneously allowing for heterogeneous error variances and regression coefficients. We propose an alternative parameterization of our model that makes the objective function convex and the penalty scale invariant. To improve computational efficiency, we propose an approximate version of our method and study its theoretical properties. Our method provides a substantial improvement in protein expression prediction accuracy in individuals of African ancestry, and in a downstream PWAS analysis, leads to the discovery of multiple associations between protein expression and blood lipid traits in the African ancestry population.
The effect of carbon nanotubes and titanium dioxide incorporated in PDMS on biofilm community composition and subsequent mussel plantigrade settlement
Creators: name: Yang, Jin-Long
name: Li, Yi-Feng
name: Xing-Pan Guo
name: Liang, Xiao
name: Xu, Yue-Feng
name: Ding, De-Wen
name: Bao, Wei-Yang
name: Dobretsov, Sergey
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: This study investigated the effect of carbon nanotubes (CNTs) and titanium dioxide (TiO2) incorporated in PDMS on biofilm formation and plantigrade settlement of Mytilus coruscus. TiO2 increased bacterial density, and CNTs also increased bacterial density but reduced diatom density in biofilms after 28 days. Further analysis was conducted between bacterial communities on glass, PDMS, CNTs (0.5 wt%) and TiO2 (7.5 wt%). ANOSIM analysis revealed significant differences (R > 0.9) between seven, 14, 21 and 28 day-old bacterial communities. MiSeq sequencing showed that CNTs and TiO2 impacted the composition of 28 day-old bacterial communities by increasing the abundance of Proteobacteria and decreasing the abundance of Bacteroidetes. The maximum decreased settlement rate in 28 day-old biofilms on CNTs and TiO2 was > 50% in comparison to those on glass and PDMS. Thus, CNTs and TiO2 incorporated in PDMS altered the biomass and community composition of biofilms, and subsequently decreased mussel settlement.
title: Parole émergée: 128 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (infirmière/patient) en structure de soin ambulant en addictologie
Comment on ‘New insights on Franciscan Complex geology, architecture, depositional age, and provenance for the western Mt. Tamalpais area, Marin County, California’ by Bero et al. (2020)
Creators: name: Graymer, Russell W.
name: Dumitru, Trevor A.
name: McLaughlin, Robert J.
name: Wentworth, Carl M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Serious errors and inconsistencies in the article undermine many of its interpretations to the point that principal conclusions are not valid. Much dependence is placed on the maximum depositional age (Dmax) of sandstone units based on zircon analysis of 10 samples, but calculation of those Dmax values is flawed, and their use confuses maximum with actual depositional ages and makes age distinctions finer than the resolution of the data. Conclusions that are compromised include the concept of a westward/downward-younging tectonostratigraphic stack of accretionary units, comparison of mapped sandstones with other California Coast Ranges sandstones, comparison of timing of events recorded in the map area with regional events, identification of mélange only in a narrow band in the study area, and detrital provenance of some of the sandstone units.
Additional file 8 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8: Figure S2. Subgroup assignment and phylogenetic tree of bathyarchaeotal genomes containing all 16 ribosomal proteins.
title: Parole émergée: 133 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (infirmière/patient) en structure de soin ambulant en addictologie
title: Parole émergée: 142 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (médecin/patient) en structure de soin ambulant en addictologie
MPEC 2024-E42 : 2005 EN70
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Parole émergée: 155 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (infirmière/patient) en structure de soin ambulant en addictologie
Evaluation of Ki-67 expression and large cell content as prognostic markers in MZL: a multicenter cohort study
Creators: name: Christian, Beth
name: Tavakkoli, Montreh
name: Anampa-Guzmán, Andrea
name: Torka, Pallawi
name: Bartlett, Nancy L.
name: Reves, Heather
name: Hansinger, Emily
name: Grover, Natalie S.
name: Shouse, Geoffrey
name: Epperla, Narendranath
name: Olszewski, Adam J.
name: Annunzio, Kaitlin
name: Thomas, Colin
name: Barta, Stefan K.
name: Karmali, Reem
name: Watkins, Marcus
name: Geethakumari, Praveen Ramakrishnan
name: Oh, Timothy S.
Publisher: name: Springer Nature
Year: 2024

description: Marginal zone lymphoma (MZL) can have varied presentations and pathologic features, including high Ki-67 expression ( > 20%) as well as increased numbers of large B cells (LC). However, there are limited data available demonstrating the prognostic significance of these variables in patients with MZL. In this multi-institutional retrospective cohort study of patients with MZL treated at 10 centers, we evaluated the association between the presence of Ki-67 expression and increased LCs on survival and risk of histologic transformation (HT). A total of 785 patients were included (60% with extranodal MZL, 20% with nodal MZL, and 20% with splenic MZL). Among the 440 patients with Ki-67 staining, 22% had high Ki-67 (Ki-67 >20%). The median progression-free survival (PFS) for patients with high Ki-67 was 5.4 years compared to 7.0 years for patients with low Ki-67 (HR = 1.45, 95%CI = 1.03–2.05). Ki-67 > 20% strongly correlated with high LDH level. The risk of HT was higher in patients with increased Ki-67 than those without (5-year risk, 9.8% vs 3.87%, p = 0.01). Twelve percent of patients had LC reported on biopsy with 6% having >10% LC. The presence of LC was associated with high Ki-67 (p < 0.001), but not associated with shorter PFS or overall survival (OS). The cumulative risk for HT was higher in patients with LC compared to those without LC (5-year risk, 9.4% vs 2.9%, p = 0.04). Receipt of anthracycline-based therapy did not impact PFS or OS in either group. Ki-67 staining >20% was a prognostic factor for worse survival and strongly correlated with elevated LDH. Novel therapies should be investigated for their potential ability to overcome the high-risk features in MZL. Our data reinforce the importance of obtaining biopsies at relapse or progression, particularly in patients with baseline high Ki-67 and increased LCs, given their increased risk for HT.
Desequilibrio en las carreras de ciencias y letras.pdf
Creators: name: Mª Milagros Ruiz Gómez
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Estudio para averiguar cuál es la percepción que tienen los jóvenes a la hora de elegir una carrera u otra para así conocer a qué se debe el desequilibrio en ciencias y letras.
Electronic Supplementary Material from Soluble hexamethyl-substituted subphthalocyanine as a dopant-free hole transport material for planar perovskite solar cells
Creators: name: Wang, Feng
name: Liu, Xiaoyuan
name: Rezaee, Ehsan
name: Shan, Haiquan
name: Zhou, Yuxia
name: Xu, Zong-Xiang
Publisher: name: The Royal Society
Year: 2018

description: Boron subphthalocyanine (SubPc) has special physical and chemical properties, originating from its non-centrosymmetric, near-planar taper structure and large conjugated system; it can act as an alternative to the small molecule hole-transporting material 2,2′,7,7′-tetrakis-(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene in perovskite solar cells (PSCs). To achieve a higher solubility in common organic solvents and a more suitable highest occupied molecular orbital energy level that aligns with the valence band of the perovskite material, a SubPc molecule with a hexamethyl substitution at its peripheral position (Me6-SubPc) was successfully designed and synthesized in a one-step method. Completely solution processed PSCs were fabricated with only a small hysteresis, a power conversion efficiency of 6.96% and Voc of 0.986 V.
title: Parole émergée: 144 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi social (éducateur/psychologue) en structure de soin ambulant en addictologie
Identifying System-Level Strategies to Engage in HPV Prevention Across Oral Health and Primary Care Settings
Creators: name: Egan, Kathleen L.
name: Maness, Sarah B.
name: Al-Dajani, Mahmoud
name: Richman, Alice R.
name: Sanchez, Leslie
name: Flores, Andres
name: Torres, Essie
Publisher: name: MDPI
Year: 2024

description: Introduction: HPV vaccination prevents most HPV-related cancers, yet uptake remains low. HPV is linked to an estimated 70% of oropharyngeal cancers (OPCs) in the US and outnumber cases of HPV-related cervical cancers. Not all OPCs can be detected through routine screening, making HPV vaccination a more effective primary prevention strategy. However, bridging primary and oral healthcare faces challenges due to a lack of referral networks between practices. The purpose of this study is to identify key infrastructure elements and policies, as well as HPV prevention strategies, among an academic practice network of dental clinics and partnering community health clinics in a southeastern state. Methods: Researchers held interviews with directors and focus groups with staff at six dental clinics and eight associated community clinics in a southeastern state. Interviews and focus groups at dental and community clinics were analyzed by two study team members using thematic analysis with Nvivo software. Results: A total of 90 participants participated in all focus groups and interviews (N = 14 interviews, 10 focus groups (5–13 participants per focus group). Most participants identified as white (58.9%) and female (70%), with an average age of 38.5 years. Researchers identified nine key study themes: three specific to the dental clinics’ HPV conversations with patients, two related to community clinics’ vaccine provision, and four involving the relationship between the dental and co-located community clinics. Dental clinic staff do not currently discuss HPV with patients. They are open to discussing HPV with patients but anticipate barriers that require preparation to overcome them. Community clinics have demonstrated previous success with HPV vaccination, but patients over the age of 18 face financial barriers to vaccination. Community clinics and dental clinics report that they do not currently have existing referral networks but are open to a referral system between practices if infrastructure is put into place to support it. Conclusions: Our findings indicate that there is interest in, and potential for, increased discussion of HPV with dental patients and collaboration between dental and community clinics for HPV vaccination referral. The results of this investigation can be used to develop intervention strategies to increase HPV vaccination through referrals between dental clinics and nearby community clinics. Ultimately, this work can reduce health inequities in HPV-related cancers, serve as a model for US dental practices, and possibly influence public health policy.
Additional file 9 of Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
Creators: name: Pan, Jie
name: Zhou, Zhichao
name: Béjà, Oded
name: Cai, Mingwei
name: Yang, Yuchun
name: Liu, Yang
name: Gu, Ji-Dong
name: Li, Meng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Figure S3. The metagenomic and transcriptomic coverages of nine bathyarchaeotal genomes in this study.
Report on local, national and EU scenarios
Creators: name: Doračić, B.
name: Knoefel, J.
name: Naber, N.
Publisher: name: Zenodo
Year: 2020
Subjects: scenarios
renewables
technology
prosumers
PROSEU
Europe

description: This deliverable analyses various technical scenarios of renewable prosumer integration to determine the full potential for the uptake of such technologies. Three general scenarios were developed with three different reference years (reference scenario: 2015, 2030, 2050; renewables scenario: 2030, 2050; and autarky scenario: 2030, 2050). The Reference scenario ensures comparability with business as usual. The renewables scenario shows the impact of maximizing the energy production with renewable prosumer technologies and the Autarky scenario shows how storage technologies can improve self-sufficiency. In order to consider the future technology developments and trends in the energy sector, all the scenarios have been modelled for 2030 and 2050, while the base year has been set as 2015. The scenarios are developed for different levels of use cases. In total 30 local technology deployment scenarios are analysed, along with the analysis of 28 countries and the EU. For the 30 local deployment scenarios in total 10 use cases were analysed. The use cases have been selected in such a way that a broad range of climate, geographical social and political conditions are considered so that the results could be replicated to similar cases throughout Europe.
description: H2020 project PROSEU - Prosumers for the Energy Union: Mainstreaming active participation of citizens in the energy transition. Deliverable 5.2
Achilles tendinopathy treatment via circadian rhythm regulation
Creators: name: Bai, Wubin
name: Jiang, Qing
name: Li, Lan
name: Leigh, Weisbecker Hannah
name: Wang, Peng
name: Cai, Hongling
name: Zhang, Lin
name: Zhang, Yibo
name: Wu, Yizhang
name: Wang, Yong
name: Lu, Yang
name: Yan, Wenjin
name: Lu, Jun
name: Xu, Xingquan
Publisher: name: Elsevier
Year: 2024

description: Introduction Achilles tendinopathy (AT) is a prevalent musculoskeletal disorder closely linked to oxidative stress. Existing evidence suggests a potential link between circadian clock rhythms and oxidative stress. However, the precise role of the circadian clock in the progression and treatment of AT remains unclear. Objective The purpose of this study was to investigate the role of the Achilles tendon circadian clock in AT pathology and explore the potential use of biomaterials for modulating the circadian clock in the treatment of AT. Methods We utilized in vivo and in vitro models to investigate the alterations of the circadian clock within the Achilles tendon during the progression of AT, as well as its impact on disease development. Additionally, we fabricated Nb2C@CeO2 composites featuring a Schottky heterojunction for regulating the circadian rhythm and validated its therapeutic efficacy and molecular mechanism of AT through both in vivo and in vitro experiments. Results The Achilles tendon functioned as a peripheral oscillator with an independent and self-sustained time-keeping system. The rhythm of the Achilles tendon clock was disrupted during the development of AT, as indicated by the decreased amplitude of Bmal1 and Nrf2 rhythm expression. Mechanistically, the knockdown of Bmal1 disrupted the Achilles tendon clock, thereby destroying the Bmal1-Nrf2 axis dependent molecular defense mechanism, and exacerbating the inflammatory response, whereas overexpression of Bmal1 had a protective effect. Nb2C@CeO2 composites with Schottky heterojunctions enhance intercellular electrical signaling, boosting Bmal1 expression and mitigating AT’s pathological changes. Importantly, enhancing Bmal1 expression during its peak, rather than its trough, was more effective. Conclusion This study identified the protective role of the circadian clock against oxidative stress and inflammation in the Achilles tendon. Achilles tendon circadian clock-targeted therapy represents a promising strategy for AT treatment.
title: Parole émergée: 167 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (infirmière/patient) en structure de soin ambulant en addictologie
Aptamer-gelatin composite material for prolonging PDGF-BB release
Creators: name: Boonchoy Soontornworajit
name: Karnjana Kerdsiri
name: Thawatchai Tungkavet
name: Anuvat Sirivat
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2020
Subjects: gelatin
aptamer
composite
PDGF-BB
protein release

description: Songklanakarin Journal of Science and Technology, 42, 1, 180-187
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ РАЗРЫВОВ ЗАДНЕГО КОРНЯ МЕДИАЛЬНОГО МЕНИСКА КОЛЕННОГО СУСТАВА
Creators: name: Турсунов, В.Х.
name: Бабакулов, А.Ш.
Publisher: name: Zenodo
Year: 2025

description: С появлением и активным развитием современных лучевых методов диагностики — магнитно‑резонансной томографии (МРТ), мультиспиральной компьютерной томографии (МСКТ), ультразвукового исследования (УЗИ) высокого разрешения, а также методик контрастной артрографии — врачи получили возможность не только выявлять, но и детально характеризовать ранее «скрытые» или малоизвестные патологии крупных суставов человека.
Improving telmisartan mechanical properties through the formation oftelmisartan and oxalic acid co-crystal by slow evaporation andultrasound assisted co-crystallization from solution methods
Creators: name: Hestiary Ratih
name: Pamudji, Jessie Sofia
name: Alatas, Fikri
name: Sundani Nurono Soewandhi
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2020
Subjects: telmisartan
oxalic acid
co-crystal
slow evaporation
ultrasound assisted co-crystallization from solution

description: Songklanakarin Journal of Science and Technology, 42, 1, 188-195
Квартильний підхід до проблеми стимулювання росту наукової продуктивності в університетах України
Creators: name: Nazarovets, Serhii
Publisher: name: figshare
Year: 2016
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: It was suggested to apply alternative quartile-approach to the issue of awarding Ukrainian Universities' staff with the aim to improve their publication activity which considers the peculiarities of different research disciplines.
Synthesis of tetrazoles, triazoles, and imidazolines catalyzed by magnetic silica spheres grafted acid
Creators: name: Jiang, Ruihang
name: Sun, Hong-Bin
name: Li, Shuang
name: Zhan, Kun
name: Zhou, Junjie
name: Liu, Lei
name: Zhang, Kai
name: Liang, Qionglin
name: Chen, Zhangpei
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Hematology

description: The magnetically separable catalysts are used in the synthesis of N-containing heterocycles, including tetrazoles, triazoles, and imidazolines. The magnetic silica sphere grafted sulfonic acid (MSS-SO3H) is suitable for the synthesis of 1,2,3-triazole via the cycloaddition of nitroalkene with NaN3, whereas the zinc-modified silica sphere catalyst (MSS-SO3Zn) is more suitable for the synthesis of tetrazoles. The MSS-SO3Zn catalyst also works well for the synthesis of 2-substituted imidazoline via the condensation of nitriles with ethylenediamine. Both of the MSS-SO3H and MSS-SO3Zn catalysts can be recovered easily by a magnet, and they can be reused without further tedious activation.
In-beam spectroscopy reveals competing nuclear shapes in the rare isotope 62Cr
Creators: name: Porzio, Carlotta
name: Farris, Peter
name: Rubino, Elizabeth
name: Janssens, Robert V. F.
name: Crider, Benjamin P.
name: Gillespie, Stephen
name: Carpenter, Michael P.
name: Poves, Alfredo
name: Hill, Ava M.
name: Chung-Jung, Joseph
name: Longfellow, Brenden
name: Gade, Alexandra
name: Weisshaar, Dirk
name: Campbell, Christopher M.
name: Noji, Shumpei
name: Pereira, Jorge
name: Basson, Marshall J.
name: Ayangeakaa, Akaa D.
name: Lenzi, Silvia M.
name: Dao, Duc D.
name: Tostevin, Jeffrey A.
name: Nowacki, Frédéric
name: Crawford, Heather L.
Publisher: name: Springer Nature
Year: 2024

description: In recent decades, rare-isotope facilities have enabled the study of short-lived, neutron-rich nuclei. Their measured properties indicate that shell structure changes in the regime of unbalanced neutron-to-proton ratios compared with that of stable nuclei. In the so-called islands of inversion in the nuclear chart—around the neutron-rich nuclei 32Mg, 42Si and 64Cr, for example—the textbook shell model predicts spherical shapes due to the respective magic neutron numbers of 20, 28 and 40 of these nuclei. However, nuclei in these regions turn out to be deformed in their ground states. Another hallmark of these islands is shape coexistence, where a nucleus assumes different shapes with excitation energy. Here we present evidence for this phenomenon from the observation of an excited 0+ state in 62Cr, two neutrons away from the heart of the island of inversion around neutron number N = 40. We use large-scale shell-model calculations to interpret the results, and we report extrapolations for the doubly magic nucleus 60Ca.
Finite element input mesh & data files
Creators: name: Vavourakis, Vasileios
name: Bjoern Eiben
name: Hipwell, John
Publisher: name: figshare
Year: 2016
Subjects: subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering

description: This compressed folder contains the patient-specific FE models that consists of the all necessary input files to run the simulations of the in-silico oncoplasic breast surgery, as well as the corresponding finite element meshes.
All files can be opened using a conventional text editor, while the finite element meshes can be viewed using Gmsh (http://gmsh.info/).
Convergence on CaMK4: a key modulator of autism-associated signaling pathways in neurons
Creators: name: Hannan, Anthony J.
name: Oakhill, Jonathan S.
name: Risteska, Alana
name: Kemp, Bruce E.
name: Scott, John W.
name: Gundlach, Andrew L.
name: Hill-Yardin, Elisa L.
name: Muller, Abbey G.
name: Cousin, Margot A.
name: Means, Anthony R.
name: Drewry, David H.
name: Febbraio, Mark A.
name: Berk, Michael
name: Kaiser, Jacqueline
name: Nay, Kevin
name: Sun, Haoxiong
name: Lei, Bethany
Publisher: name: Elsevier
Year: 2024

description: Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For a large number of people living with profound autism, this genetic heterogeneity has impeded the identification of common biological targets for therapy development for core and comorbid traits that include significant impairments in social communication, and repetitive and restricted behaviors. A substantial number of genes associated with autism encode proteins involved in signal transduction and synaptic transmission that are critical for brain development and function. CAMK4 is an emerging risk gene for autism spectrum disorder that encodes the Ca2+-calmodulin-dependent protein kinase-4 (CaMK4) enzyme. CaMK4 is a key component of a Ca2+-activated signaling pathway that regulates neurodevelopment and synaptic plasticity. In this review, we discuss three genetic variants of CAMK4 found in individuals with hyperkinetic movement disorder and comorbid neurological symptoms including autism spectrum disorder that are likely pathogenic with monogenic effect. We also comment on four other genetic variations in CAMK4 that display associations with autism spectrum disorder, as well as twelve examples of autism-associated variations in other genes that impact CaMK4 signaling pathways. Finally, we highlight three environmental risk factors that impact CaMK4 signaling based on studies in preclinical models of autism and/or clinical cohorts. Overall, we review molecular, genetic, physiological, and environmental evidence that suggest defects in the CaMK4 signaling pathway may play an important role in a common autism pathogenesis network across numerous patient groups, and propose CaMK4 as a potential therapeutic target.
title: Parole émergée: 170 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi médical (infirmière/patient) en structure de soin ambulant en addictologie
Quality evaluation using TLC methods with reference to brazilin contentof Caesalpinia sappan heartwoods in Thailand
Creators: name: Suwipa Intakhiao
name: Chanida Palanuvej
name: Nijsiri Ruangrungsi
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2020
Subjects: Caesalpinia sappan heartwood
brazilin
pharmacognostic specification
TLC-image analysis
TLC-densitometry

description: Songklanakarin Journal of Science and Technology, 42, 1, 196-202
Phenols displaying tyrosinase inhibition from Humulus lupulus
Creators: name: Kim, Dae Wook
name: Woo, Hyun Sim
name: Kim, Jeong Yoon
name: Ryuk, Jin Ah
name: Park, Ki Hun
name: Ko, Byoung Seob
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Tyrosinase is the rate-limiting enzyme for the production of melanin and other pigments via the oxidation of l-tyrosine. The methanol extract from Humulus lupulus showed potent inhibition against mushroom tyrosinase. The bioactivity-guided fractionation of this methanol extract resulted in the isolation of seven flavonoids (1–7), identified as xanthohumol (1), 4′-O-methylxanthohumol (2), xanthohumol C (3), flavokawain C (4), xanthoumol B (5), 6-prenylnaringenin (6) and isoxanthohumol (7). All isolated flavonoids (1–7) effectively inhibited the monophenolase (IC50s = 15.4–58.4 µM) and diphenolase (IC50s = 27.1–117.4 µM) activities of tyrosinase. Kinetic studies using Lineweaver–Burk and Dixon-plots revealed that chalcones (1–5) were competitive inhibitors, whereas flavanones (6 and 7) exhibited both mixed and non-competitive inhibitory characteristics. In conclusion, this study is the first to demonstrate that the phenolic phytochemicals of H. lupulus display potent inhibitory activities against tyrosinase.
Additional file 12 of Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population
Creators: name: Ma, Xia
name: Wu, Yanping
name: Zhang, Ling
name: Yuan, Weilan
name: Yan, Li
name: Fan, Sha
name: Lian, Yunzhi
name: Zhu, Xia
name: Gao, Junhui
name: Zhao, Jiangman
name: Zhang, Ping
name: Tang, Hui
name: Jia, Weihua
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Additional file 12: Table S9. The efficacy of KNN, LR, SVM, DT, MLP and XGboost in the training set of top 5 ranked features.
Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies
Creators: name: Alanazi, Amer M.
name: Abdel-Aziz, Alaa A.-M.
name: Taghreed Z. Shawer
name: Rezk R. Ayyad
name: Abdulrahman M. Al-Obaid
name: Al-Agamy, Mohamed H. M.
name: Azza R. Maarouf
name: El-Azab, Adel S.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Some new derivatives of substituted-4(3H)-quinazolinones were synthesized and evaluated for their in vitro antitumor and antimicrobial activities. The results of this study demonstrated that compound 5 yielded selective activities toward NSC Lung Cancer EKVX cell line, Colon Cancer HCT-15 cell line and Breast Cancer MDA-MB-231/ATCC cell line, while NSC Lung Cancer EKVX cell line and CNS Cancer SF-295 cell line were sensitive to compound 8. Additionally, compounds 12 and 13 showed moderate effectiveness toward numerous cell lines belonging to different tumor subpanels. On the other hand, the results of antimicrobial screening revealed that compounds 1, 9 and 14 are the most active against Staphylococcus aureus ATCC 29213 with minimum inhibitory concentration (MIC) of 16, 32 and 32 μg/mL respectively, while compound 14 possessed antimicrobial activities against all tested strains with the lowest MIC compared with other tested compounds. In silico study, ADME-Tox prediction and molecular docking methodology were used to study the antitumor activity and to identify the structural features required for antitumor activity.
Personal care product use and per- and polyfluoroalkyl substances in pregnant and lactating people in the Maternal-Infant Research on Environmental Chemicals study
Creators: name: Braun, Joseph M
name: Rawn, Dorothea FK
name: Hall, Amber M
name: Dodds, Linda
name: Yolton, Kimberly
name: Borghese, Michael M
name: Chen, Aimin
name: Buckley, Jessie P.
name: Cecil, Kim M
name: Papandonatos, George D.
name: Ashley-Martin, Jillian
name: Fisher, Mandy
name: Arbuckle, Tye E
name: Liang, Chun Lei
name: Lanphear, Bruce P.
Publisher: name: Elsevier
Year: 2024

description: Background Per- and polyfluoroalkyl substances (PFAS) are ubiquitous chemicals routinely detected in personal care products (PCPs). However, few studies have evaluated the impact of PCP use on PFAS concentrations in pregnant and lactating populations. Objective We investigated associations between PCP use and PFAS concentrations in prenatal plasma and human milk. Methods We leveraged the Maternal-Infant Research on Environmental Chemicals (MIREC) Study to evaluate the contribution of PCP use on PFAS concentrations in prenatal plasma (6–13 weeks’ gestation; n = 1,940) and human-milk (2–10 weeks’ postpartum; n = 664). Participants reported frequency of use across 8 PCP categories during the 1st and 3rd trimesters, 1–2 days postpartum, and 2–10 weeks’ postpartum. We used linear regression models to quantify covariate-adjusted percent differences and corresponding 95 % confidence intervals. Results In 1st trimester pregnant people, we found higher use of nailcare products (≥once a week vs never: perfluorooctanoic acid (PFOA): 21 % [9.7 %, 32 %]; perfluorooctane-sulfonic acid (PFOS): 11 % [0.3 %, 23 %]), fragrances (daily vs never: PFOA: 14 % [7.8 %, 21 %]; PFOS: 7.8 % [1.3 %, 15 %]), makeup (daily vs. never: PFOA: 14 % [5.8 %, 23 %]), hair dyes (never vs. > twice during pregnancy: PFOA: 8.3 % [2.4 %, 15 %]), and hair sprays or gels (daily vs. never: PFOA: 12 % [5.0 %, 19 %], PFOS: 7.1 % [0.2 %, 15 %], PFHxS: 9.9 % [0.6 %, 20 %]) were associated with higher plasma PFAS concentrations. Similar results were observed for 3rd trimester PCP use and 2–10 weeks’ postpartum human-milk PFAS concentrations. In addition, we found that people using colored-permanent dye 1 to 2 days postpartum had higher Sm-PFOS (18 % [ 2.7, 35]), PFOA (16 % [4.3 %, 29 %]), and perfluorononanoic acid (17 % [3.6 %, 33 %]) postpartum human-milk concentrations. Conclusions Our results show that PCP use may be a modifiable source of PFAS exposure in pregnant and lactating populations. These results along with growing scientific evidence can help inform PFAS regulation and guide individual choices to reduce PFAS exposure.
The Population History of Domestic Sheep Revealed by Paleogenomes
Creators: name: Atağ, Gözde
name: Gündem, Can Yumni
name: Valipour, Hamid Reza
name: Canpolat, Kayra
name: Günther, Torsten
name: Götherström, Anders
name: Grange, Thierry
name: De Cupere, Bea
name: Duru, Refik
name: Baird, Douglas
name: Togan, İnci Z
name: Ochir-Goryaeva, Maria
name: Kazancı, Duygu Deniz
name: Somel, Mehmet
name: Bıçakçı, Erhan
name: Arbuckle, Benjamin S
name: Hachem, Lamys
name: Baloğlu, Fatma Küçük
name: Buluktaev, Aleksey
name: Umurtak, Gülsün
name: Abazari, Mohammad Foad
name: Fakhari, Zohre
name: Özbal, Rana
name: Çevik, Özlem
name: Vural, Kıvılcım Başak
name: Gerritsen, Fokke
name: Miranda, Pedro Morell
name: Geigl, Eva-Maria
name: Pişkin, Evangelia
name: Akbaba, Ali
name: Yüncü, Eren
name: Hadjisterkotis, Eleftherios
name: Doğu, Ayça Küçükakdağ
name: Kaptan, Damla
name: Çakan, Yasin Gökhan
name: Yorulmaz, Sevgi
name: Kukanova, Viktoria
name: Hoseinzadeh, Javad
name: Özer, Füsun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise location(s) and timing(s) of earliest domestication, or the post-domestication history of sheep. Here, we present 24 new partial sheep paleogenomes, including a 13,000-year-old Epipaleolithic Central Anatolian wild sheep, as well as 14 domestic sheep from Neolithic Anatolia, two from Neolithic Iran, two from Neolithic Iberia, three from Neolithic France, and one each from Late Neolithic/Bronze Age Baltic and South Russia, in addition to five present-day Central Anatolian Mouflons and two present-day Cyprian Mouflons. We find that Neolithic European, as well as domestic sheep breeds, are genetically closer to the Anatolian Epipaleolithic sheep and the present-day Anatolian and Cyprian Mouflon than to the Iranian Mouflon. This supports a Central Anatolian source for domestication, presenting strong evidence for a domestication event in SW Asia outside the Fertile Crescent, although we cannot rule out multiple domestication events also within the Neolithic Fertile Crescent. We further find evidence for multiple admixture and replacement events, including one that parallels the Pontic Steppe-related ancestry expansion in Europe, as well as a post-Bronze Age event that appears to have further spread Asia-related alleles across global sheep breeds. Our findings mark the dynamism of past domestic sheep populations in their potential for dispersal and admixture, sometimes being paralleled by their shepherds and in other cases not.
Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: can Asphodeline roots be considered as a new source of natural compounds?
Creators: name: Gokhan Zengin
name: Locatelli, Marcello
name: Ceylan, Ramazan
name: Aktumsek, Abdurrahman
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Plant-based foods have become attractive for scientists and food producers. Beneficial effects related to their consumption as dietary supplements are due to the presence of natural occurring secondary metabolites. In this context, studies on these products are important for natural and safely food ingredients evaluation. The aim of this study was to evaluate root extract of eight Asphodeline species as antioxidants, enzyme inhibitors and phytochemical content. Spectrophotometric antioxidant and enzyme inhibitory assays were performed. Total phenolic and flavonoids contents as well as the chemical free-anthraquinones profiles were determined using routinely procedure (HPLC-PDA). Data show that Asphodeline roots can be considered as a new source of natural compounds and can be used as a valuable dietary supplement. Some differences related to biological activities can be inferred to other phytochemicals that can be considered in the future for their synergic or competitive activities.
Additional file 13 of Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population
Creators: name: Ma, Xia
name: Wu, Yanping
name: Zhang, Ling
name: Yuan, Weilan
name: Yan, Li
name: Fan, Sha
name: Lian, Yunzhi
name: Zhu, Xia
name: Gao, Junhui
name: Zhao, Jiangman
name: Zhang, Ping
name: Tang, Hui
name: Jia, Weihua
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Additional file 13: Table S10. The efficacy of KNN, LR, SVM, DT, MLP and XGboost in the test set of 9 SNPs features.
Megastudy testing 25 treatments to reduce antidemocratic attitudes and partisan animosity
Creators: name: Cikara, Mina
name: Pink, Sophia L
name: Pasek, Michael H
name: Almeida Santos, Luiza
name: Gallardo, Roman A
name: Dorison, Charles
name: Luo, Kara
name: Kelly, John Michael
name: Yeager, David S
name: Lees, Jeffrey
name: Strand, Palma
name: Felsman, Peter
name: Güngör, Mertcan
name: Clapper, Margarett V
name: Mehl, Caroline
name: Javeed, Ali
name: Martherus, James
name: Zaki, Jamil
name: Dieffenbach, Macrina
name: Tomz, Michael
name: Moore, Molly
name: Rosato, Jay
name: Hall, Matthew
name: Kirk, James R G
name: Levendusky, Matthew
name: Willer, Robb
name: Shariff, Azim
name: DeFilippis, Evan
name: Franz, Michael
name: Chu, James Y
name: Cashman, Matthew
name: Celniker, Jared B
name: Lyons, Ben
name: Littman, Rebecca
name: Keating, Brandyn
name: Allis, L Victor
name: Kay, Aaron C
name: Gifford, Sara
name: Stone, Daniel F
name: Yoeli, Erez
name: Baleria, Gina
name: Allen, Levi G
name: Greene, Joshua
name: Rahnama, Hossein
name: Fiorella, Maya
name: Simonsson, Otto
name: Kteily, Nour
name: Druckman, James N
name: Blunden, Hayley
name: Jost, John T
name: Moore-Berg, Samantha L
name: Spitz Siddiqi, Shiri
name: Rathje, Steve
name: Doell, Kimberly C
name: Gray, Kurt
name: Redekopp, Chrystal
name: Rand, David G
name: Kubin, Emily
name: Ghezae, Isaias
name: Lyles, Aaron
name: Seifert, Colleen M
name: Hecht, Cameron A
name: Marsh, Wayde
name: Mernyk, Joseph S
name: Voelkel, Jan G
name: Bryan, Christopher J
name: Clayton, Katherine
name: Duong, Mylien
name: Braley, Alia
name: Maurer, Lauren Alpert
name: Green, Joe
name: Goya-Tocchetto, Daniela
name: Adjodah, Dhaval
name: Lenz, Gabriel
name: Minson, Julia
name: Kay, Nick R
name: Saar-Tsechansky, Maytal
name: Van Bavel, Jay J
name: Puryear, Curtis
name: Kopell, Malka
name: Stagnaro, Michael N
name: Ballantyne, Nathan
name: Pentland, Alex
name: Collins, Hanne
name: Francis, David
Publisher: name: American Association for the Advancement of Science (AAAS)
Year: 2024

description: Scholars warn that partisan divisions in the mass public threaten the health of American democracy. We conducted a megastudy (n = 32,059 participants) testing 25 treatments designed by academics and practitioners to reduce Americans' partisan animosity and antidemocratic attitudes. We find that many treatments reduced partisan animosity, most strongly by highlighting relatable sympathetic individuals with different political beliefs or by emphasizing common identities shared by rival partisans. We also identify several treatments that reduced support for undemocratic practices-most strongly by correcting misperceptions of rival partisans' views or highlighting the threat of democratic collapse-which shows that antidemocratic attitudes are not intractable. Taken together, the study's findings identify promising general strategies for reducing partisan division and improving democratic attitudes, shedding theoretical light on challenges facing American democracy.
Additional file 10 of Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population
Creators: name: Ma, Xia
name: Wu, Yanping
name: Zhang, Ling
name: Yuan, Weilan
name: Yan, Li
name: Fan, Sha
name: Lian, Yunzhi
name: Zhu, Xia
name: Gao, Junhui
name: Zhao, Jiangman
name: Zhang, Ping
name: Tang, Hui
name: Jia, Weihua
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Additional file 10: Table S8. The efficacy of KNN, LR, SVM, DT, MLP and XGboost in the training set of 5 Clinical features.
title: Parole émergée: 176 corrKP
Creators: name: Ploog, Katja
name: Equoy-Hutin, Séverine
name: Mariani-Rousset, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: Français
subject: fra

description: Interaction de soin/au travail : rendez-vous de suivi social (éducateur/psychologue) en structure de soin ambulant en addictologie