cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular characterization of thyroid tumors of dogs – a multicentric Portuguese series
Creators: name: Monteiro, A.
name: Gaspar, T. B.
name: Pinto, M.
name: Pires, I.
name: Soares, P.
name: Tavares, C.
Publisher: name: Scientific Letters
Year: 2023

description: Background: The incidence of thyroid carcinoma (TC) in human population has been increasing worldwide, and it was estimated an incidence of 2.1% of cancer new cases in 2019 [1]. A smaller incidence is reported for canine population (1.1%) in 1995-2005 [2]. Diagnosis, prognosis, and management of human TC rely on mutation screening of BRAF, RAS genes, and TERT promoter. BRAF, NRAS, HRAS, and KRAS encode proteins that are key effectors of MAPK signaling pathway, an important kinase pathway, conserved in mammals [3]. Objective: Our goal was to explore the canine TC’s oncobiology, and to verify whether natural occurring canine TC could (or not) be set as suitable model to study its human homolog. Methods: We collected 57 samples (5 adenomas (9%), and 52 carcinomas (91%)), from which we performed DNA extraction from formalin-fixed paraffin-embedded tissues, PCR, and Sanger sequencing of exon 16 of BRAF (n = 49), exon 2 of NRAS (n = 41), exon 3 of HRAS (n = 41), and exon 3 (n = 31) and 4 (n = 20) of KRAS. Results: We detected silent mutations on HRAS (p.N47=) (n = 14/41, 34%) and NRAS (p.E63=) (n = 1/41, 2.4%), however, no mutations were found in the other genes. Conclusions: Our results corroborate those described by Campos et al. (2014) [4]. Nevertheless, both studies only evaluated the homologous regions of the hotspots of human most common TC mutations. We cannot exclude the hypothesis that in dogs, those genes can present activating mutations in other exons, different from human’s hotspots.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Wood quality of trembling aspen (Populus tremuloides Michx) and white spruce (Picea glauca (Moench) Voss) in the boreal mixedwood forest
Creators: name: De Araujo, Francis Raiche
Publisher: name: University of British Columbia
Year: 2012

description: The boreal forest is the most widespread forest type in Canada, with a large percentage represented by mixedwood forests of white spruce (Picea glauca (Moench) Voss) and trembling aspen (Populus tremuloides Michx). It serves as not only a vast ecological reserve, but also as the supply source for forest-based industries. A better understanding of the interactions between the different species and their affects on productivity and wood quality traits helps create a more efficient industry that better utilizes the available resources, and concurrently preserves as much forest of ecological reserves and societal vistas. In this study, three sites composed of trembling aspen and white spruce, with varying compositions (one composed of mainly aspen, one of mainly spruce, and a mixed site with both species) were compared to determine how the presence of one species affects the growth and wood quality traits of the other. Four main wood quality traits were examined: wood density, microfibril angle (MFA), fibre traits (fibre length, fibre width and fibre coarseness) and cell wall chemistry. Along with site comparisons, social classes were determined for each site in an attempt to provide a more in-depth comparison across sites. Wood density showed very little variation among sites for both species, with only significant variations occurring between social classes. The aspen site showed statistically lower MFAs than the aspen from the mixed site, however, no differences were observed between the spruce from the mixed and spruce sites. Fibre length, width and coarseness were higher in the pure species sites for both trembling aspen and white spruce. In terms of cell wall composition, there were no differences in carbohydrate contents across sites for both species. Lignin content did vary, with the aspen site possessing higher lignin content than the mixed site, while for spruce the spruce site showed a lower lignin content. Overall, the use of social classes did not refine the characterization of site, producing similar results to those obtained when comparing trees by site, regardless of class.
title: Следователь (дознаватель) в уголовном судопроизводстве. Курс лекций
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2020

description: Предлагаемый курс лекций написан в соответствии с учебной программой по специальному курсу «Следователь (дознаватель) в уголовном судопроизводстве» на основе действующего уголовно-процессуального законодательства РФ. В учебном пособии обобщены опыт расследования преступлений, уголовно-процессуальное законодательство и специальная литература, на основе чего раскрыт процессуальный порядок деятельности следователя (дознавателя) по возбуждению и расследованию уголовных дел, принятию решений и составлению иных процессуальных документов, дан обязательный минимум действий по уголовным делам и рекомендации по осуществлению расследования преступлений. По каждой теме курса составлены вопросы для обсуждения и тесты для проверки знаний обучающихся. Книга рассчитана на практических работников правоохранительных органов, адвокатов, преподавателей и обучающихся юридических вузов.
Supplementary document for Ideal suppression of Bessel beam intensity oscillations with a vortex phase plate - 6617147.pdf
Creators: name: Zhang, Xiao-Tong
name: Liu, Shan-Shan
name: Zhang, Xin
name: Wang, Guocui
name: Ye, Jia-Sheng
name: Feng, Shengfei
name: Wang, Xinke
name: Han, Peng
name: sun, wenfeng
name: Quan, Baogang
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental document
The Frobenius group T13 and the canonical see-saw mechanism applied to neutrino mixing
Creators: name: Hartmann, Christine
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The compatibility of the Frobenius group T13 with the canonical see-saw mechanism of neutrino mixing is examined. The Standard Model is extended in a minimalist way, by introducing a family symmetry and three right-handed neutrinos. To fit experiments and place constraints on the possibilities, tribimaximal mixing is used as a guideline. The application of both a family symmetry group and the canonical see-saw mechanism naturally generates small neutrino masses. The various possibilities from combining these two models are listed. Enough constraints are produced to narrow down the parameters of the neutrino mass matrix to two. This is therefore a predictive model where neutrino mass eigenvalues and allowed regions for neutrinoless double beta decay are suggested.
description: Accepted for publication in Physical Review D. 13 pages
Species richness of Myxobolus (Cnidaria, Myxozoa) parasites infecting thicklip grey mullet Chelon labrosus in the Douro River, Portugal
Creators: name: Guimarães, J.
name: Casal, G.
name: Alves, A.
name: Araújo, C.
name: Rocha, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Myxozoans are widespread cnidarian parasites that mostly infect fish and annelids as temporary and definitive hosts, respectively [1]. Mullets are a diverse fish group, which ubiquitous nature leaves vulnerable to parasitic infections [2]. Objective: This study aimed to acknowledge the myxozoan diversity infecting thicklip grey mullet Chelon labrosus in the Douro River estuary in northern Portugal. Methods: The internal and external organs of 13 specimens were macro- and microscopically examined. Cysts and infected tissues were individually photographed and processed for sequencing of the small subunit ribosomal gene (18S rDNA). Phylogenetic reconstructions were performed using maximum likelihood and Bayesian inference methodologies. Results: Eleven potentially new Myxobolus spp. were morphologically described and molecularly characterized. Additionally, a novel host, geographic region and morphometric profile was reported for Myxobolus pupkoi Gupta et al., 2022. Molecular comparisons further matched two of the novel Myxobolus sequences with sphaeractinomyxon types previously reported from marine oligochaetes in another Portuguese estuary. Phylogenetic analyses revealed the novel sequences clustering according to host affinity, with tree topologies resolving well-supported lineages of myxobolids infecting mullets from the genera Chelon, Mugil, Crenimugil and Planiliza. Conclusions: The elevated number of potentially novel Myxobolus spp. found in C. labrosus confirmed the successful hyperdiversification of these myxozoans in mullets [2], further reinforcing molecular-based comparisons as imperative for taxonomic descriptions. Morphometrical divergence between geographical isolates of M. pupkoi was hypothesized to correlate with adaptation to distinct abiotic factors and annelid communities. The formation of more than one Chelon-infecting lineage revealed that myxobolids entered this genus multiple times during their evolution. Lastly, the matching of two novel Myxobolus sequences with sphaeractinomyxon types reinforces the latter as specific life-cycle counterparts of mugiliform-infecting Myxobolus [3]. The large number of unmatched sphaeractinomyxon sequences positioned within the Chelon lineages suggests that Myxobolus diversity in Portuguese estuaries remains underestimated.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
A Role for Exchange of Extracellular Vesicles in Porcine Spermatogonial Co-Culture
Creators: name: Thiageswaran, Shiama
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: spermatogonial stem cells
subject: spermatogonia
subject: co-cultures
subject: extracellular vesicles
subject: pig
subject: Biology
subject: Biology--Molecular
subject: Biochemistry

description: Spermatogonial stem cells (SSCs) provide the basis for lifelong male fertility through self-renewal and differentiation. Prepubertal male cancer patients may be rendered infertile by gonadotoxic chemotherapy and, unlike sexually mature men, cannot store sperm. Testicular biopsies taken prior to treatment may be used to restore fertility in adulthood. Testicular SSC populations are limited, necessitating in vitro culture systems to increase the numbers of SSCs available for downstream applications. Using the pig as a non-rodent model, we developed spermatogonial culture systems to expand spermatogonia from 1- and 8-week-old porcine testes, comparing feeder layers consisting of populations enriched for Sertoli cells, peritubular myoid cells (PMCs), pig fetal fibroblasts (PFFs), and testicular endothelial cells (TECs). As previously developed porcine spermatogonial culture systems relied exclusively on Sertoli cell feeder layers, we explored whether constituent cells of the SSC niche, such as PMCs and TECs, or fibroblastic cells like PFFs, may also support SSC expansion. Spermatogonia co-cultured with PMCs and PFFs had comparable rates of proliferation and apoptosis to spermatogonia co-cultured with Sertoli cells. To elucidate the mechanism behind the beneficial nature of feeder layers, we investigated the role of extracellular vesicles in the dynamic crosstalk between spermatogonia and feeder cells. Sertoli cell-released exosomes were found to be taken up by spermatogonia, and the inhibition of exosomal release reduced spermatogonial proliferation.
title: Praxisnah in den Beruf. Herausragende Diplomarbeiten des Studienjahres 2000/2001
Creators: name: Fachhochschule Münster
Publisher: name: FH Münster
Year: 2003
Subjects: subject: 330 Wirtschaft

description: In Kooperation mit namhaften Firmen und Institutionen sind im Absolventenjahrgang 2001 wertvolle Diplomarbeiten entstanden, deren Ergebnisse in die dortigen Abläufe nutzbringend integriert wurden. Das zeugt von der fachlichen Kompetenz der Diplomanden. Die hier prämierten "Top Ten" zeichnen sich in besonderer Weise durch ihren Praxis-, Wissenschafts- und Anwendungsbezug aus und werden deshalb bezug geehrt.
Acute toxicity screening of 4-chloroaniline in freshwater standard species
Creators: name: Rebelo, D.
name: Antunes, S. C.
name: Rodrigues, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Aromatic amines are commonly used in the production of pigments, dyes, pharmaceuticals, pesticides, and laboratory chemicals​ [1]​. Due to inappropriate discard and the ineffectiveness of wastewater treatment plants in removing these compounds, they are frequently detected in aquatic ecosystems​ [2]​, leading to 4-chloroaniline being considered a candidate for the 4th Watch List under the Water Framework Directive​ [3]​, to determine the risk it poses to the aquatic environment. Objective: To evaluate the biological effects (individual and sub-individual responses) of standard species from different trophic levels, after exposure to 4-chloroaniline. Methods: A toxicity screening was performed regarding the ecotoxicological effects on Allivibrio fischeri (bioluminescence inhibition), Raphidocelis subcapitata (growth inhibition), Lemna minor (growth inhibition and biomarker assessment) and Daphnia magna (immobilization/mortality, reproductive effects and biomarker assessment). Results: The 4-chloroaniline exposure showed an A. fischeri effect concentration of EC50(30 min) = 1.99 mg/L. Preliminary results demonstrate that R. subcapitata should be the most sensitive organism. L. minor presented an EC50(7 d) = 82.84 mg/L. L. minor sub-individual results showed a significant decrease (≥ 93.75 mg/L) in the photosynthetic pigments content; a significant increase in catalase and glutathione S-transferases activities; and a significant decrease in lipid peroxidation. D. magna showed an EC50(48 h) = 0.102 mg/L and, after a subchronic exposure (10 days), a significant decrease in N1 fecundity was recorded above 13.89 µg/L. Catalase and Glutathione S-transferases activities were only significantly increased at 13.89 mg/L. Conclusions: Results showed that 4-chloroaniline has an ecotoxicologically relevant effect in aquatic organisms, with an impact on several biochemical pathways, ultimately affecting individuals (survival, growth and reproduction responses). To better understand the effects of exposure to 4-chloroaniline in non-target organisms, more studies (e.g., chronic assays) should be conducted to produce data to help policy decisions related to monitoring and regulating these compounds in surface waters.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Soft Spectrum in Yukawa-Gauge Mediation
Creators: name: Galli, Federico
name: Mariotti, Alberto
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce a model independent parametrization for a subclass of gauge mediated theories, which we refer to as Yukawa-gauge mediation. Within this formalism we study the resulting soft masses in the visible spectrum. We find general expressions for the gaugino and scalar masses. Under generic conditions, the gaugino mass is screened, vanishing at first order in the SUSY breaking scale.
description: 22 pages, 4 figures; v2: minor corrections, published version
Drug poisoning profile in Portugal: a special focus on antipsychotics
Creators: name: Araújo, A. R. T. S.
name: Gallardo, E.
name: Rato, F.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Acute poisoning is a major public and preventable global health problem, contributing to morbidity and mortality in many parts of the world. Most patients with acute poisoning are treated as outpatients in hospital emergency departments. Acute poisoning occurs soon after exposure to either single or multiple toxic substances. Poisoning cases may be intentional or unintentional. Objective: The aim of the present study was to carry out a drug poisoning profile in Portugal with a special focus on the antipsychotic drugs. Methods: This work describes the retrospective and descriptive analysis of the information reported to Centro de Informação Antivenenos (CIAV) from 2019 to 2021 [1]. Data analysis focused on the main toxic involved in poisonings. Results: In Portugal there is a prevalence of non-intentional poisonings, affecting more adults than children, the overwhelming majority occurring by ingestion. The main agents involved were medicines (60.4%), domestic/industrial products (21.7), biocides/phytopharmaceuticals (5.6%), substances of abuse (5.5%) and cosmetics (2.7%). Regarding drug poisonings, it was verified that the pharmacotherapeutic groups most involved were anxiolytics and sedative-hypnotics (27.4%), antipsychotics (11.1%), antidepressants (10.5%), non-steroidal anti-inflammatory drugs (8.1%) and paracetamol (7.8%). There was an increasing trend of poisonings with Central Nervous System (CNS) drugs in these 3 years, from 44.2% and 64.6%. The antipsychotics occupied the second position, with emphasis for quetiapine. This drug has become widely used for a variety of indications because of its favorable side effectand safety profile. Patients with an acute overdose of quetiapine may demonstrate central nervous system depression, sinus tachycardia, prolonged QTc interval, hypotension, coma, and seizures [2]. Conclusions: Since drug intoxications representa public health problem, it is of utmost importance to highlight to the rational use of the medicines, namely CNS drugs, and therefore the need of the improvement in the prevention and education in this field is mandatory.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Complete ionisation of the neutral gas: why there are so few detections of 21-cm hydrogen in high redshift radio galaxies and quasars
Creators: name: Curran, S. J.
name: Whiting, M. T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: From the first published z > 3 survey of 21-cm absorption within the hosts of radio galaxies and quasars, we found an apparent dearth of cool neutral gas at high redshift. From a detailed analysis of the photometry, each object is found to have a 1216 A continuum luminosity in excess of L ~1e23 W/Hz, a critical value above which 21-cm has never been detected at any redshift. At these wavelengths, and below, hydrogen is excited above the ground state so that it cannot absorb in 21-cm. In order to apply the equation of photoionsation equilibrium, we demonstrate that this critical value also applies to the ionising (< 912 A) radiation. We use this to show, for a variety of gas density distributions, that upon placing a quasar within a galaxy of gas there is always an ultra-violet luminosity above which all of the gas in the galaxy is ionised. While in this state the hydrogen cannot be detected nor cannot engage in star formation. Applying the mean ionising photon rate of all of the sources searched, we find, using canonical values for the gas density and recombination rate coefficient, that the observed critical luminosity gives a scale-length (3 kpc) similar that of the neutral hydrogen (HI) in the Milky Way, a large spiral galaxy. Thus, this simple, yet physically motivated, model can explain the critical luminosity, above which neutral gas is not detected. This indicates that these galaxies are probably devoid of star-forming material, rather the non-detection of 21-cm being due to the sensitivity limits of current radio telescopes.
description: Accepted by ApJ
Development and Evaluation of a Framework for Mentor-Based Engineering Outreach
Creators: name: Dornian, Katherine
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: engineering education
subject: mentoring
subject: STEM outreach
subject: K-12 outreach
subject: Education
subject: Engineering

description: Diversity in engineering teams and organizations is needed to solve the complex challenges the world is facing. However, the number of people from historically underrepresented groups—such as women, Indigenous, Black, and Hispanic engineers—falls short of parity with the population [1-4].Mentoring programs successfully improve interest in engineering and perceptions of the field for people in the groups mentioned above [5-8]. Mentor-based outreach is a growing practice that attracts these historically excluded people to study engineering. While frameworks exist for implementing outreach and mentoring programs, there is not yet a framework that informs mentor-based engineering outreach. A solid framework is needed to improve practices and outcomes. In this thesis, I use in-depth analysis of a local mentor-based engineering outreach initiative and review twenty-four external programs to develop a framework for mentor-based engineering outreach. The final framework includes six critical dimensions and eight components to inform design, implementation, and evaluation of programs. This research also shows how structuring mentor-based outreach around technical skill development and relationships encourages positive social and personal development outcomes, such as increasing student interest in engineering. Ultimately, this work provides practitioners and organizations with direction for improving diversity within outreach programs.
Development of the Rapid Test Kit for the Identification of Campylobacter spp. Based on Loop-mediated Isothermal Amplification (LAMP) in Combination with a Lateral Flow Dipstick (LFD) and Gold Nano-DNA Probe (AuNPs)
Creators: name: Kosum Chansiri
Publisher: name: กองบริหารการวิจัย
Year: 2019
Subjects: Campylobacter
Loop-mediated isothermal amplification
Lateral flow dipstick
Gold nano-DNA probe

description: Science & Technology Asia, 24, 1, 63-71
title: Процессуальные документы досудебного производства по уголовному делу
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2020

description: Предлагаемое учебное пособие написано в соответствии с учебной программой по специальному курсу «Следователь (дознаватель) в уголовном судопроизводстве» на основе действующего уголовно-процессуального законодательства РФ. В учебном пособии содержатся образцы уголовно-процессуальных документов, которые составлены на основе реальных уголовных дел и могут использоваться преподавателем при чтении лекций, проведении практических занятий, а обучающимися в ходе самостоятельной работы для формирования навыков составления уголовно-процессуальных документов в ходе возбуждения уголовного дела и предварительного расследования. Книга рассчитана на практических работников правоохранительных органов, адвокатов, преподавателей и обучающихся юридических вузов.
Inhibitory activity of psilocybin/psilocin towards the enzymes of the cytochrome P450 (CYP450): an in vitro evaluation
Creators: name: Brito-Da-Costa, A. M.
name: Silva-Carvalho, M.
name: Dinis-Oliveira, R. J.
name: Madureira-Carvalho, Á.
name: Dias Da Silva, D.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Psilocybin is a hallucinogen produced by several “magic mushrooms” [1,2]. This prodrug is rapidly metabolized in the organism by alkaline phosphatases and esterases into psilocin, the active drug [1,2]. A scientific gap exists regarding the possible interactions between psilocybin/psilocin and CYP450 enzymes. Since the binding of drugs to CYP450 enzymes can interfere with the metabolism of other substrates leading to drug-drug interactions, this research topic is of utmost importance. Objective: This study aimed to assess potential inhibitory interactions between psilocybin/psilocin and CYP3A4, 2D6, 2B6 and 2A6. Methods: The in vitro assessment of CYP450 inhibition was performed using the Vivid®CYP450 screening kits, following the user’s guide. Concentrations of psilocybin and psilocin ranged between 1.14´10-13 - 4 mM and 6.1´10-5 - 1 mM for CYP3A4; 1.71´10-13 - 8 mM and 6.1´10-5 - 1 mM for CYP2D6; 2.4´10-4 - 8 mM and 2.4´10-5 - 1 mM for CYP2B6; and 3.8´10-6 - 2 mM and 7.6´10-8 - 1 mM for CYP2A6, respectively. Each test condition was mixed with baculosomes expressing the specific CYP, Vivid® regeneration system, NADP+, and a non-fluorescent substrate. Solvent and positive controls of inhibition, i.e., ketoconazole (CYP3A4), quinidine (CYP2D6), miconazole (CYP2B6) and tranylcypromine (CYP2A6,) were included. Fluorescence was measured for 60 minutes (Ex=415/20nm; Em=460/20nm) and the half-maximal inhibitory concentration (IC50) calculated using GraphPad prism 9.3.0. For CYP3A4 and 2D6 a minimum of three independent experiments were performed, and two independent experiments for CYP2A6 and 2B6. Results: For psilocybin, IC50 values of 49.43 mM (CYP3A4), >1000 mM (CYP2D6 and 2B6), and >300 mM (CYP2A6) were attained. For psilocin, the following IC50 values were obtained: 2.12 mM (CYP3A4), 11.89 mM (CYP2D6), 0.99 mM (CYP2A6) and 4.05 mM (CYP2B6). Conclusions: The results suggest a potential for psilocin to be an inhibitor of all the enzymes evaluated, especially CYP2A6, contrary to psilocybin which seems to only have the potential to inhibit CYP3A4.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Data and Software: Upsampling Monte Carlo Reactor Simulation Tallies in Depleted LWR Assemblies Fueled with LEU and HALEU using a Convolutional Neural Network
Creators: name: Osborne, Andrew
name: Berry, Jessica
name: Romano, Paul
Publisher: name: Zenodo
Year: 2023

description: Data and software for generating results in the paper " Upsampling Monte Carlo Reactor Simulation Tallies in Depleted LWR Assemblies Fueled with LEU and HALEU using a Convolutional Neural Network".
A kinetic theory of diffusion in general relativity with cosmological scalar field
Creators: name: Calogero, Simone
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: A new model to describe the dynamics of particles undergoing diffusion in general relativity is proposed. The evolution of the particle system is described by a Fokker-Planck equation without friction on the tangent bundle of spacetime. It is shown that the energy-momentum tensor for this matter model is not divergence-free, which makes it inconsistent to couple the Fokker-Planck equation to the Einstein equations. This problem can be solved by postulating the existence of additional matter fields in spacetime or by modifying the Einstein equations. The case of a cosmological scalar field term added to the left hand side of the Einstein equations is studied in some details. For the simplest cosmological model, namely the flat Robertson-Walker spacetime, it is shown that, depending on the initial value of the cosmological scalar field, which can be identified with the present observed value of the cosmological constant, either unlimited expansion or the formation of a singularity in finite time will occur in the future. Future collapse into a singularity also takes place for a suitable small but positive present value of the cosmological constant, in contrast to the standard diffusion-free scenario.
description: 17 pages, no figures. The present version corrects an erroneous statement on the physical interpretation of the results made in the original publication
title: Профессиональная этика юриста. Хрестоматия
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2020

description: В хрестоматию включены кодексы этики, содержащие требования к профессиональной деятельности юриста и сотрудников правоохранительных органов, а также тексты – извлечения из трудов мыслителей разных эпох, содержащих высказывания об этических категориях. Хрестоматия предназначена для студентов юридических вузов, изучающих курс профессиональной этики и служебного этикета, а также для практических работников системы правоохранительных органов.
influence of glutathione pathway modulators on the cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cardiac cells
Creators: name: Vitorino-Oliveira, C.
name: Kahremany, S.
name: Nisim, L.
name: Duarte-Araújo, M.
name: Carvalho, F.
name: Gruzman, A.
name: Costa, V. M.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Cancer survivorship has grown over the years due to more efficacious treatments. Nonetheless, anticancer treatments present serious adverse effects, namely cardiotoxicity. Doxorubicin (DOX), a topoisomerase II inhibitor; sunitinib (SUN), a multikinase inhibitor; and bortezomib (BTZ), an inhibitor of proteasome, have their clinical use limited because of their cardiotoxicity. Cardiotoxicity is often linked to oxidative stress. Nuclear factor erythroid 2–related factor 2 (Nrf2) controls the expression of the antioxidant response element and is an important emerging regulator of oxidative stress response. Nrf2 regulates glutathione (GSH) homeostasis, being this the most important cellular antioxidant. Objective: To study the influence of Nrf2 activators, like SK-119 and SH-29, and GSH modulators, namely its precursor N-acetylcysteine (NAC) and the γ-glutamylcysteine synthetase inhibitor, L-buthionine sulfoximine (BSO) on the cytotoxicity of SUN, DOX and BTZ in human differentiated AC16 cardiac cells. Methods: AC16 cells were differentiated with horse serum and then exposed to different concentrations of SUN (1–20µM) or DOX (0.1–10µM) or BTZ (0.01–20µM) for twenty-four or forty-eight hours to assert their cytotoxicity. The two cytotoxicity assays done were the MTT reduction and neutral red uptake assays. Then, two concentrations of SUN (1 and 10µM), DOX (0.1 and 1µM) and BTZ (1 and 0.01µM) were co-incubated with BSO, NAC, SK-119 or SH-29. Results: A time and concentration-dependent cytotoxicity was observed in the anticancer therapies, being the degree of toxicity as follows: BTZ>DOX>SUN when using equimolar concentrations. Regarding data with Nrf2/GSH modulators, a small but significant protection was achieved with NAC towards the cytotoxicity of DOX. BSO had no effects on the cytotoxicity of the anticancer agents. SK-119 and SH-29 are still being evaluated, showing no relevant cytotoxicity in the micromolar range. Conclusions: This work showed that DOX, SUN and BTZ cause significant cytotoxicity in AC16 cells, being GSH pathways involved in DOX toxicity. Nonetheless, more studies are needed, being key to determine the role of Nrf2 on the cytotoxicity of these anticancer therapies.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Data and Software: Upsampling Monte Carlo Reactor Simulation Tallies in Depleted LWR Assemblies Fueled with LEU and HALEU using a Convolutional Neural Network
Creators: name: Osborne, Andrew
name: Berry, Jessica
name: Romano, Paul
Publisher: name: Zenodo
Year: 2023

description: Data and software for generating results in the paper " Upsampling Monte Carlo Reactor Simulation Tallies in Depleted LWR Assemblies Fueled with LEU and HALEU using a Convolutional Neural Network".
title: Практикум по дисциплине «Судебная экспертиза»
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2020

description: Предлагаемое учебное пособие включает в себя практические задания по темам семинарских занятий для самостоятельного и аудиторного закрепления пройденного материала и отработки навыков по составлению процессуальных документов в ходе назначения судебных экспертиз и оценке полученных по результатам судебно-экспертных исследований заключений экспертов. Учебное пособие рассчитано на использование при проведении занятий по дисциплинам «Судебная экспертиза», «Криминалистика». Предназначено для студентов юридических факультетов и вузов.
Improving Infectious Tuberculosis Education and Counselling in Calgary for Patients who are Foreign-born and their Families
Creators: name: Bedingfield, Nancy Joyce
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: tuberculosis
subject: patient education and counselling
subject: patient and family centred care
subject: qualitative methods
subject: Public Health

description: Patients and family members require comprehensive information and support to manage tuberculosis (TB). However, current TB education and counselling practices often fail to address family needs. This is particularly true in low TB incidence settings such as Canada, where linguistic and cultural dissonance between patients and providers is common. The objective of this research was to explore how TB health care workers (TB HCWs) and health systems leaders can focus education and counselling on the needs and preferences of patients and family members who are foreign-born experiencing advanced infectious TB in Calgary, Canada. The case study was conducted in three phases framed on the Social Ecological Model. In phase one, interviews were conducted with patients and family members to learn about their TB-related needs and experiences. In phase two, staff and physicians at the Calgary TB Clinic were interviewed to learn about their perceptions of barriers and supports to education and counselling for this group. In phase three, data from the first two phases were re-analyzed, relevant documents were reviewed, and health services and community leaders were interviewed to learn how health policy and social context influence education and counselling. Patients and family members described significant isolation associated with TB. Although patients and family members were satisfied with education and counselling, there was evidence that communication problems had occurred. TB HCWs reported numerous, multi-level barriers to providing education and counselling but found that continuity of care and clear information provided early reduced communication problems. Data from community leaders’ interviews and document review revealed that operational and public health priorities often took precedence over strengthening education and counselling. Leaders noted promising developments had recently increased attention to the needs of people who are foreign-born. Key recommendations for change include development of patient education and counselling guidelines, improved patient teaching materials, and offering a cultural patient navigator to families affected by advanced infectious TB. Adopting these changes could reduce fear and isolation in patients and family members; however, policy changes is required to realize the equity-enhancing potential of informing and supporting patients and family members affected by TB.
Line mixing in parallel and perpendicular bands of CO2: A further test of the refined Robert-Bonamy formalism
Creators: name: Boulet, C.
name: Ma, Qiancheng
name: Tipping, R. H.
Publisher: name: Columbia University
Year: 2015
Subjects: Carbon dioxide
Fourier transformations
Angular momentum
Chemistry, Physical and theoretical
Sum rules (Physics)

description: Starting from the refined Robert-Bonamy formalism [Q. Ma, C. Boulet, and R. H. Tipping, J. Chem. Phys. 139, 034305 (2013)], we propose here an extension of line mixing studies to infrared absorptions of linear polyatomic molecules having stretching and bending modes. The present formalism does not neglect the internal degrees of freedom of the perturbing molecules, contrary to the energy corrected sudden (ECS) modelling, and enables one to calculate the whole relaxation matrix starting from the potential energy surface. Meanwhile, similar to the ECS modelling, the present formalism properly accounts for roles played by all the internal angular momenta in the coupling process, including the vibrational angular momentum. The formalism has been applied to the important case of CO2 broadened by N2. Applications to two kinds of vibrational bands (Σ → Σ and Σ → Π) have shown that the present results are in good agreement with both experimental data and results derived from the ECS model.
Wearable Multi-Sensor Positioning Device for Rowing Technique Analysis
Creators: name: Rodriguez Mendoza, Luis Alejandro
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: ultra-wideband, inertial navigation, GNSS, wearable technology, rowing
subject: Education--Technology
subject: Engineering

description: The goal of this research project was to determine the feasibility of a wearable multi-sensor positioning device to be used as a training tool to evaluate rowing technique, and to determine the positioning accuracy using multiple mathematical models and estimation methods. The wearable device consists of an inertial measurement unit, an ultra-wideband ranging transceiver, and a global navigation satellite systems receiver. To evaluate the performance of the system, two experiments were conducted. The first experiment was performed in a controlled laboratory setting with a rowing machine at varying stroke rates, the purpose of this experiment was to validate the positioning algorithms and evaluate the accuracy of the results. The second experiment took place outdoors on a rowing boat. This experiment analyzed the rowing motion in multiple navigation frames and with various positioning methods. The results show that the wearable device is a viable option for rowing technique analysis, and the positioning accuracy can be achieved in the decimeter level with some of the methods and sensors.
title: Preisgekrönt in den Beruf .Herausragende Diplomarbeiten des Studienjahres 2001/2002
Creators: name: Fachhochschule Münster
Publisher: name: FH Münster
Year: 2003
Subjects: subject: 330 Wirtschaft

description: Herausragende Diplomarbeiten des Studienjahres 2001/2002.
Massive star formation in the GMC G345.5+1.0: Spatial distribution of the dust emission
Creators: name: López, C.
name: Bronfman, L.
name: Nyman, L. -Å.
name: May, J.
name: Garay, G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We attempt to make a complete census of massive-star formation within all of GMC G345.5+1.0. This cloud is located one degree above the galactic plane and at 1.8 kpc from the Sun, thus there is little superposition of dust along the line-of-sight, minimizing confusion effects in identifying individual clumps. We observed the 1.2 mm continuum emission across the whole GMC using the Swedish-ESO Submillimetre Telescope Imaging Bolometer Array mounted on the SEST. Observations have a spatial resolution of 0.2 pc and cover 1.8 deg\times 2.2 deg in the sky with a noise of 20 mJy/beam. We identify 201 clumps with diameters between 0.2 and 0.6 pc, masses between 3.0 and 1.3\times10^3 Msun, and densities between 5\times10^3 and 4\times10^5 cm^-3. The total mass of the clumps is 1.2\times10^4 Msun, thus the efficiency in forming these clumps, estimated as the ratio of the total clump mass to the total GMC mass, is 0.02. The clump mass distribution for masses between 10 and 10^3 Msun is well-fitted by a power law dN/dM proportional to M^-alpha, with a spectral mass index alpha of 1.7+/-0.1. Given their mass distribution, clumps do not appear to be the direct progenitors of single stars. Comparing the 1.2 mm continuum emission with infrared images taken by the Midcourse Space Experiment (MSX) and by the SPITZER satellite, we find that at least 20% of the clumps are forming stars, and at most 80% are starless. Six massive-star forming regions embedded in clumps and associated with IRAS point sources have mean densities of ~10^5 cm^-3, luminosities >10^3 Lsun, and spectral energy distributions that can be modeled with two dust components at different mean temperatures of 28+/-5 and 200+/-10 K.
In vitro permeability of MDPV across Caco-2 cells for assessment of intestinal absorption and enantioselectivity
Creators: name: Almeida, A. S.
name: Silva, B.
name: Remião, F.
name: Fernandes, C.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone (MDPV), are widely studied chiral psychoactive substances [1]. Enantioselectivity studies on the toxicokinetic of synthetic cathinones are still scarce [2], namely on their ability to cross the intestinal membrane, which was evaluated only for methylone and pentedrone [3]. To isolate enantiomers for these studies, liquid chromatography (LC) using chiral columns has been the technique of choice [4]. Objective: The aims of this work were the semi-preparative enantioresolution of the enantiomers of MDPV and development and validation of an UHPLC-UV method to further evaluate the potential enantioselectivity in intestinal permeability using the Caco-2 cell line. Methods: A semi-preparative LC method using a polysaccharide-based column was optimized to obtain the enantiomers of MDPV. Caco-2 monolayers were exposed to each enantiomer and samples were collected and quantified by UHPLC-UV. For the validation of the UHPLC-UV method, specificity, linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) and samples’ stability were evaluated [5]. Results: The enantiomers were successfully separated by the optimized LC method with good resolution (Rs of 1.7) and enantioselectivity (α of 1.4), being collected with high enantiomeric ratios (>95%) and recovery rates (>92%). Regarding the UHPLC-UV, high selectivity and good linearity were obtained (r2 > 0.999). Acceptable accuracy (between 102-109%) and inter-day and intra-day precisions (CV < 15%) low LOD and LOQ values (0.063 μM and 0.19 μM, respectively) were also observed. Samples were stable for 6 weeks of storage in different temperatures (room temperature, 4 °C, -20 °C and -80 °C). Conclusions: The enantiomers of MDPV were found to be highly permeable across the Caco-2 monolayer and enantioselectivity was found for the Papp values in the basolateral (BL) to apical (AP) direction.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Состав преступления
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2019

description: Учебное пособие подготовлено в соответствии с программой курса «Уголовное право России» для освоения обучающимися тем, относящихся к составу преступления. В пособии раскрываются следующие вопросы: понятие состава преступления, объект преступления, объективная сторона преступления, субъект преступления, субъективная сторона преступления. Учебное пособие предназначено для студентов юридических факультетов и вузов, обучающихся по программам бакалавриата и специалитета.
Libraries are for Everyone: Library Goals for First-Year International Students at a Campus Library
Creators: name: Reed, Emily
Publisher: name: Zenodo
Year: 2021
Subjects: Library Science
international students
library instruction

description: This article identifies lesson objectives and describes the need for affective goals for first-year undergraduate international students. In order for instruction librarians to meet cognitive needs of international students, they must first meet safety and belonging needs.
description: The Newsletter can be downloaded or viewed in full here: https://repository.ifla.org/handle/123456789/1770
Dark Matter and Dark Energy via Non-Perturbative (Flavour) Vacua
Creators: name: Tarantino, Walter
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A non-perturbative field theoretical approach to flavour physics (Blasone-Vitiello formalism) has been shown to imply a highly non-trivial vacuum state. In a previous work, we implemented the approach on a simple supersymmetric model (free Wess-Zumino), with flavour mixing, which was regarded as a model for free neutrinos and sneutrinos. The resulting effective vacuum (called "flavour vacuum") was found to be characterized by a strong SUSY breaking. In this paper we explore the phenomenology of the model and we argue that the flavour vacuum is a consistent source for both Dark Energy (thanks to the bosonic sector of the model) and Dark Matter (via the fermionic one). Quite remarkably, besides the parameters connected with neutrino physics, in this model no other parameters have been introduced, possibly leading to a predictive theory of Dark Energy/Matter. Despite its oversimplification, such a toy model already seems capable to shed some light on the observed energy hierarchy between neutrino physics, Dark Energy and Dark Matter. Furthermore, we move a step forth in the construction of a more realistic theory, by presenting a novel approach for calculating relevant quantities and hence extending some results to interactive theories, in a completely non-perturbative way.
description: 14 pages, 2 figures
Irreversible Compression of Dimensional Coherence in Chaotic Systems
Creators: name: Todd, Ian
Publisher: name: Zenodo
Year: 2025

description: This paper introduces dimensional coherence, defined as the structured alignment of multiple degrees of freedom within chaotic systems, which enables deterministic control despite irreducibly complex internal states. It demonstrates that projecting dimensional coherence into lower-dimensional outputs involves an irreversible compression of internal information, fundamentally linked to Landauer’s principle and associated thermodynamic constraints. This framework extends existing complexity theories by explicitly elucidating how internal dimensional richness translates into coherent external influence via inherently asymmetric relationships. To quantitatively assess dimensional coherence, the Dimensional Coherence Index (DCI) is proposed, integrating dynamical systems theory, information theory, and topological data analysis. The proposed framework yields explicit, empirically testable hypotheses with direct relevance to neuroscience, studies of expertise, and artificial intelligence, offering novel insights into consciousness, biological adaptability, and the robust design of complex adaptive systems.
Vaping Additives Affect Lateral Organization and Functionality of Lung Surfactant Model Systems
Creators: name: Van Bavel, Nicolas
Publisher: name: Science
Year: 2022
Subjects: subject: Vaping additives
subject: Lung surfactant
subject: Biophysics

description: Recent use of THC-based vapes has led to an outbreak of respiratory health issues. While the pathology is unresolved, common symptoms point to dysfunction of the lung surfactant (LS). This is a lipid-protein monofilm situated at the air-water interface in alveolar sacs, which acts to lower surface tension, preventing lung collapse during respiration. Inhaled substances that reach the alveoli will encounter LS. Certain vape additives have been identified as potential causative agents, these being tetrahydrocannabinol and cannabidiol, commonly found in THC products, as well as vitamin E and its derivative vitamin E acetate. The lipophilic nature of these additives may allow them to partition into the monofilm, wherein they could interact with lipids to disrupt proper function. The aim of this thesis was to use model surfactants to better understand the interactions between vaping additives and the primary lipid components of lung surfactant. These films were made up of phosphatidylcholines, phosphatidylglycerols, and cholesterol. Additionally, the clinical surfactant BLES was also used and compared to the model systems. BLES is used in surfactant replacement therapy, making it a good physiological counterpart to the simple model films studied. Surface activity of the films were measured using a Langmuir-Blodgett trough which allowed for compression and expansion of the films, mimicking respiration. Changes to the lateral organization of the films was conducted with Brewster angle microscopy. Visualization of BLES was also carried out with atomic force microscopy, which allowed for higher resolution images of the surfactant’s molecular architecture. Vape additives were found to destabilize domain formations in most systems, often accompanied by fluidization of the film. The effects on BLES provided a unique insight into the mechanistic action of additive induced surfactant dysfunction. Crucial multilayer structures that form on the surface of the film during compression were abolished in the presence of vitamin E acetate, reducing the surfactants ability to maintain a low surface tension. The Langmuir-Blodgett trough has demonstrated to be useful for studying in vitro interactions between lipids and vape additives. With further optimization, this method may be used to predict in vivo effects of vape additives.