cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The Pistol-Grip Deformity is More Frequent in Patients with Axial Spondyloarthritis
Creators: name: Cilengir, Atilla
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Image verification
subject: Connective tissue disorders
subject: Diagnostic procedure
subject: Comparative studies
subject: PACS
subject: Digital radiography
subject: Musculoskeletal joint
subject: Extremities
subject: Anatomy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Femoroacetabular impingement (FAI), which causes mechanical hip pain, is characterized by early pathologic contact of the proximal femur with the acetabulum [1]. FAI is classified as pincer-type, cam-type and mixed type in which both pincer and...
Additional file 1 of A multicriteria decision analysis (MCDA) tool to purchase implantable medical devices in Egypt
Creators: name: Elezbawy, Baher
name: Fasseeh, Ahmad Nader
name: Németh, Bertalan
name: Gamal, Mary
name: Eldebeiky, Mariam
name: Refaat, Remonda
name: Taha, Amr
name: Rabiea, Shimaa
name: Abdallah, Marwa
name: Ramadan, Soha
name: Noaman, Hasnaa
name: Eldin, Amany Bahaa
name: Mostafa, Hossam
name: Nouh, Sara
name: Zaki, Asmaa
name: Abdelrahman, Mohamed
name: Abaza, Sherif
name: Kalò, Zoltàn
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. The detailed search term, databases, and number of hits for the systematic literature conducted.
title: Life after Senning surgery – long-term follow-up using MRI and CT
Creators: name: Mursic, Miroslav
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Cardiac
subject: MR
subject: CT
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the following aspects that are important in the follow-up of patients after Senning procedure: Anatomy of transposition of the great arteries (d-TGA), Atrial switch surgical procedure, Physiology of circulation after surgery, MRI and CT...
title: Preliminary results in paediatric percutaneous transthoracic procedures
Creators: name: Pittaro, Alice
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Tissue characterisation
subject: Sedation
subject: Multidisciplinary cancer care
subject: Localisation
subject: Diagnostic procedure
subject: Biopsy
subject: Ultrasound
subject: Percutaneous
subject: CT
subject: Thorax
subject: Paediatric
subject: Interventional non-vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Report our experience with percutaneous transthoracic biopsies and hook wires positioning in paediatric patients and evaluate safety and efficacy of all...
Trusynth fast study CONSORT checklist
Creators: name: Devi, Dongabanti Hemalatha
name: Bolanthakodi, Chethana
name: D’Cunha, Prema
name: Bai, Mudiki Bheema
name: Moharana, Ashok Kumar
name: TS, Deepak
Publisher: name: figshare
Year: 2022
Subjects: subject: 111402 Obstetrics and Gynaecology
subject: FOS: Clinical medicine

description: A study on two suture materials
Reversibility of time series: revealing the hidden messages in X-ray binaries and cataclysmic variables
Creators: name: Scaringi, S.
name: Maccarone, T. J.
name: Middleton, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We explore the non-linear, high-frequency, aperiodic variability properties in the three cataclysmic variables MV Lyr, KIC 8751494 and V1504 Cyg observed with Kepler, as well as the X-ray binary Cyg X-1 observed with RXTE. This is done through the use of a high-order Fourier statistic called the bispectrum and its related biphase and bicoherence, as well as the time-skewness statistic. We show how all objects display qualitatively similar biphase trends. In particular all biphase amplitudes are found to be smaller than $π/2$, suggesting that the flux distributions for all sources are positively skewed on all observed timescales, consistent with the log-normal distributions expected from the fluctuating accretion disk model. We also find that for all objects the biphases are positive at frequencies where the corresponding power spectral densities display their high frequency break. This suggests that the noise-like flaring observed is rising more slowly than it is falling, and thus not time-reversible. This observation is also consistent with the fluctuating accretion disk model. Furthermore, we observe the same qualitative biphase trends in all four objects, where the biphases display a distinct decrease at frequencies below the high-frequency break in their respective power spectral densities. This behaviour can also be observed in the time-skewness of all four objects. As far as we are aware, there is no immediate explanation for the observed biphase decreases. The biphase decreases may thus suggest that the fluctuating accretion disk model begins to break down at frequencies below the high frequency break.
description: 9 pages, 1 table, 1 figure. accepted for publication in MNRAS
title: Extra-colonic findings in Virtual Colonoscopy.
Creators: name: Barba Arce, Ana Belén
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Colon
subject: Computer Applications-Virtual imaging
subject: Technical aspects
subject: Outcomes
subject: CT-Colonography

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: - To describe the technique and indications of virtual colonoscopy. - To analyze the presence and type of extra-colonic findings in virtual colonoscopy...
Additional file 2 of A multicriteria decision analysis (MCDA) tool to purchase implantable medical devices in Egypt
Creators: name: Elezbawy, Baher
name: Fasseeh, Ahmad Nader
name: Németh, Bertalan
name: Gamal, Mary
name: Eldebeiky, Mariam
name: Refaat, Remonda
name: Taha, Amr
name: Rabiea, Shimaa
name: Abdallah, Marwa
name: Ramadan, Soha
name: Noaman, Hasnaa
name: Eldin, Amany Bahaa
name: Mostafa, Hossam
name: Nouh, Sara
name: Zaki, Asmaa
name: Abdelrahman, Mohamed
name: Abaza, Sherif
name: Kalò, Zoltàn
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. The final scoring table to be filled by the medical device assessor.
Antitumor Agents 295. E-Ring Hydroxylated Antofine and Cryptopleurine Analogues as Antiproliferative Agents: Design, Synthesis, and Mechanistic Studies
Creators: name: Lee, Kuo-Hsiung
name: Pan, Shiow-Lin
name: Ohkoshi, Emika
name: Yang, Xiaoming
name: Wang, Chih-Ya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Various E-ring hydroxylated antofine and cryptopleurine analogs were designed, synthesized, and tested against five human cancer cell lines. Interesting structure-activity relationship (SAR) correlations were found among these new compounds. The most potent compound 13b was further tested against a series of non-small cell lung cancer (NSCLC) cell lines, in which it showed impressive antiproliferative activity. Mechanistic studies revealed that 13b is able to down-regulate HSP90 and β-catenin in A549 lung adenocarcinoma cells in a dose-dependent manner, suggesting a potential use for treating Hedgehog pathway-driven tumorigenesis.
La responsabilità civile dell’impresa transnazionale per violazioni ambientali e di diritti umani: il contributo della proposta di direttiva sulla due diligence societaria a fini di sostenibilità
Creators: name: Carella, Gabriella
Publisher: name: Universita' degli Studi di Salerno
Year: 2022
Subjects: Multinational enterprise
Global Value Chain
Corporate transnational liability
Mandatory due diligence violations
Environmental and human rights violations

description: The proposal for a directive on corporate sustainability due diligence contemplates the direct civil liability of transnational companies for the negative impacts on human rights and environment of their value chains; therefore, it could be an advanced tool both to fight the impunity of multinationals and to create a European Area of Justice for people around the world. This paper is aimed at verifying whether, and to what extent, this objective can be said to be achieved. With this purpose, outlined the latest regulatory and jurisprudential developments, the subjective and objective scope of the introduced liability has been carefully investigated, also specifying the relationship with the ordinary principles of the law of tort. The private international law issues connected to the transnational character of the liability has been then examined. The limits and gaps found – even with the recognition of the undoubted innovativeness of the discipline – lead to a judgment of limited effectiveness which it is hoped to overcome thanks to specifically recommended changes.
description: La proposta di direttiva sulla due diligence societaria contempla la responsabilità civile diretta delle società transnazionali per gli impatti umani e ambientali negativi delle proprie value chains prospettandosi come strumento avanzato di lotta all’impunità delle multinazionali e di creazione di uno spazio europeo di giustizia aperto a cittadini di tutto il mondo. Verificare se e in quale misura tale obiettivo possa dirsi realizzato è la finalità del presente scritto. Pertanto, inquadrata la proposta nel contesto degli ultimi sviluppi normativi e giurisprudenziali, vengono approfonditi i presupposti soggettivi e oggettivi di applicazione della responsabilità introdotta, precisandone altresì il rapporto con il diritto comune dell’illecito civile. Vengono quindi esaminate le problematiche internazionalprivatistiche connesse al carattere transnazionale della responsabilità. I limiti e le lacune riscontrati, pur con il riconoscimento della indubbia innovatività della disciplina, inducono ad un giudizio di limitata efficacia ed effettività di cui si auspica il superamento grazie a modifiche specificamente suggerite.
Four-quark structure of the excited states of heavy mesons
Creators: name: Kim, Hungchong
name: Cheoun, Myung-Ki
name: Oh, Yongseok
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a four-quark structure for some of the excited states of heavy mesons containing a single charm or bottom quark. The four-quark wave functions are constructed based on a diquark-antidiquark form under the constraint that they form an antitriplet $\bar{\bf{3}}_f$ in $\mbox{SU(3)}_f$, which seems to be realized in some of the excited states listed in Particle Data Group. Depending on the structure of antidiquark, we construct two possible models for its wave functions: Model I) the antidiquark is symmetric in flavor ($\bar{\bf{6}}_f$) and antisymmetric in color ($\bf{3}_c$) and Model II) the antidiquark is antisymmetric in flavor ($\bf{3}_f$) and symmetric in color ($\bar{\bf{6}}_c$). To test phenomenological relevance of these wave functions, we calculate the mass differences among the excited states of spin $J=0,1,2$ using color-spin interactions. The four-quark wave functions based on Model~I is found to reproduce the observed mass of the excited states of heavy mesons. Also, our four-quark model provides an interesting phenomenology relating to the decay widths of the excited states. To further pursue the possibility of the four-quark structure, we make a few predictions for open charm and open bottom states that may be discovered in future experiments. Most of them are expected to have broad widths, which would make them difficult to be identified experimentally. However, one resonance with $J=1$ containing bottom and strange quarks is expected to appear as a sharp peak with its mass around $B^{\bar s}_{1N} \sim 5753$~MeV. Confirmation of the existence of such states in future experiments will shed light on our understanding of the structure of heavy meson excited states.
description: 15 pages, REVTeX
La violenza di genere confinata tra le pareti domestiche durante il lockdown
Creators: name: Moffa, Grazia
name: Chirivì, Marianna
Publisher: name: Universita' degli Studi di Salerno
Year: 2020
Subjects: Gender equality
Gender-based violence
Productive and re productive sphere

description: The Covid -19 pandemic has had a profound impact on our living systems and, more generally, on the economic and political organization of our country. The significant loss of human lives, the inte rruption of economic activities, the lockdown , to give just a few references, are an undoubted threat to our well -being . Rather important was the impact of the confinement on families and markedly on women , favoring the most disparate forms of abuse . In this scenario, gender -based violence is not added to the list of effects on life, but rather expresses that dimension of life – often left in the shadows – that reflects pathways of suffocated equality and rights often denied to women . Indeed, gender -based v iolence is an expression of inequality between women and men made clear by the COVID -19 outbreak. Therefore, the fight against gender -based violence remains a challenge for the 21st century. This paper aims to explore two key issues: gender inequality and interlinkage between reproduction and production sphere , focusing on pre -existing inequalities and vulnerabilities in women's life experiences.
title: Breast cancer metastasis in Armenia: dissemination on distant organ systems
Creators: name: Antonyan, Anna
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Head and neck
subject: Lung
subject: PET-CT
subject: MR-Functional imaging
subject: Ablation procedures
subject: Computer Applications-3D
subject: Vacuum assisted biopsy
subject: Cancer
subject: Haemorrhage
subject: Aneurysms

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast Cancer is the most frequently diagnosed malignant disease and the leading reason of cancer death among women from 20 to 59 years of ages and the second leading cause of death for women aged 60 and more. Firstly it starts as a local...
Ultimate limit of field confinement by surface plasmon polaritons
Creators: name: Khurgin, Jacob B
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We show that electric field confinement in surface plasmon polaritons propagating at the metal/dielectric interfaces enhances the loss due to Landau damping and which effectively limits the degree of confinement itself. We prove that Landau damping and associated with it surface collision damping follow directly from Lindhard formula for the dielectric constant of free electron gas Furthermore, we demonstrate that even if all the conventional loss mechanisms, caused by phonons, electron-electron, and interface roughness scattering, were eliminated, the maximum attainable degree of confinement and the loss accompanying it would not change significantly compared to the best existing plasmonic materials, such as silver.
title: Incidental Findings on low-resolution CT attenuation correction images: Should we look?
Creators: name: Hogg, Peter
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Thorax
subject: Lung
subject: CT
subject: SPECT-CT
subject: Diagnostic procedure
subject: Artifacts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The significance and management of incidental findings on computerised tomography attenuation correction (CTAC) images acquired during single photon emission tomography (SPECT) for myocardial perfusion imaging (MPI) have been subject to debate...
Additional file 1 of Formulation of Cinnamon (Cinnamomum verum) oil loaded solid lipid nanoparticles and evaluation of its antibacterial activity against Multi-drug Resistant Escherichia coli
Creators: name: Nemattalab, Mehran
name: Rohani, Masoumeh
name: Evazalipour, Mehdi
name: Hesari, Zahra
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Supplementary Material 1
title: MRCP: Techniques and protocols used in Greek hospitals
Creators: name: Duni, Ergesta
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Image registration
subject: Statistics
subject: FOS: Mathematics
subject: Biliary Tract / Gallbladder
subject: Abdomen
subject: MR-Cholangiography

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Over the years the MRCP techniques have been differentiated. In the most basic technique, heavily Τ2W sequences, that allow the visualization of pancreatic fluids and bile with a high signal intensity are used. The introduction of more sensitive...
Senegalese Children’s Songs, Lullabies & Hand Clapping Games
Creators: name: Roberts, Leslie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Senegal
Children's songs
Lullabies
Hand-clapping games

description: Children all around the world sing and play. In this unit of study, you will discuss how different cultures have their own children's songs, lullabies, and singing games. Students will learn to perform a song or game from the West African country of Senegal and make comparisons to songs and games that they already know and grew up with.
title: MRI in evaluation of postoperative scarring and recurrent rectal cancer
Creators: name: Otochkin, Vladimir
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Diagnostic procedure
subject: Surgery
subject: MR
subject: Oncology
subject: Colon
subject: Neoplasia
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose was to analyze opportunities of various MRI pulse sequences in differentiation of recurrent rectal cancer and scarring...
Analysis of the Massive Eclipsing Binary V1441\,Aql
Creators: name: Cakirli, O.
name: Ibanoglu, C.
name: Sipahi, E.
name: Frasca, A.
name: Catanzaro, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new spectroscopic observations of the early type, double-lined eclipsing binary V1441\,Aql. The radial velocities and the available photometric data obtained by $ASAS$ is analysed for deriving the parameters of the components. The components of V1441\,Aql are shown to be a B3\,IV primary with a mass M$_p$=8.02$\pm$0.51 M$_{\odot}$ and radius R$_p$=7.33$\pm$0.19 R$_{\odot}$ and a B9 III secondary with a mass M$_s$=1.92$\pm$0.14 M$_{\odot}$ and radius R$_s$=4.22$\pm$0.11 R$_{\odot}$. Our analyses show that V1441\,Aql is a double-contact system with rapidly rotating components. Based on the position of the components plotted on the theoretical Hertzsprung-Russell diagram, we estimate that the ages of V1441\,Aql is about 30\,Myr, neglecting the effects of mass exchange between the components. Using the UBVJHK magnitudes and interstellar absorption we estimated the mean distance to the system V1441\,Aql as 550$\pm$25\,pc.
description: 21 Pages, 4 Figures, Accepted by NEW Astronomy
Musical Activities with The Talking Baobab Tree
Creators: name: Roberts, Leslie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Folk literature, African
Senegal

description: In this lesson, students will listen to a West African folktale from Senegal and will collaborate as a whole class to arrange a musical performance to go with the story. Students will be able to lead a discussion on similarities and differences between these stories and stories/fables they already know as well as discuss the potential moral lessons presented in the tale.
Storytelling through Maps
Creators: name: Luetzow-Coward, Erica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Senegal
Maps

description:  In this lesson, students will look at different types of maps from Senegal and use them for fact finding and to draw conclusions about life, the economy, and the environment in Senegal.  Students will also create their own map that “tells a story.”
title: Know your CPPD – Don’t be “SLAC”. Pictorial Review.
Creators: name: Koo, Andrew
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Bones
subject: Digital radiography
subject: CT
subject: MR
subject: Education
subject: Arthritides
subject: Education and training
subject: Metabolic disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To understand and recognise patterns of calcium pyrophosphate dihydrate deposition disease in...
Additional file 10 of Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes
Creators: name: Ueno, Masanobu
name: Miyagawa, Ippei
name: Miyazaki, Yusuke
name: Hanami, Kentaro
name: Fukuyo, Shunsuke
name: Kubo, Satoshi
name: Nakayamada, Shingo
name: Tanaka, Yoshiya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 10: Supplementary Table S5. Comparison of activated Th1 and Th17 between DAPSA-LDA/REM responder and non-responder. Data are shown by median(quartile). P values were determined by Wilcoxon rank sum test. p*<0.05: with DAPSA-LDA responder (N = 18) vs non-responder (N = 4) at baseline, DAPSA-REM responder (N = 4) vs non-responder (N = 18) at baseline, DAPSA-LDA responder (N = 11) vs non-responder (N = 3) at 6 months, and DAPSA-REM responder (N = 3) vs non-responder (N = 11) at 6 months.
Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis
Creators: name: Zhang, Weihe
name: Branchford, Brian R.
name: Wang, Xiaodong
name: Zhou, Yingqiu
name: Machius, Mischa
name: Sather, Susan
name: Frye, Stephen V.
name: Hunter, Debra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The role of Mer kinase in regulating the second phase of platelet activation generates an opportunity to use Mer inhibitors for preventing thrombosis with diminished likelihood for bleeding as compared to current therapies. Toward this end, we have discovered a novel, Mer kinase specific substituted-pyrimidine scaffold using a structure-based drug design and a pseudo-ring replacement strategy. The co-crystal structure of Mer with two compounds (7 & 22) possessing distinct activity have been determined. Subsequent SAR studies identified compound 23 (UNC2881) as a lead compound for in vivo evaluation. When applied to live cells, 23 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with 23 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, 23 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
Religion in Architecture
Creators: name: Luetzow-Coward, Erica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: subject: Senegal
subject: Religion
subject: Architecture
subject: FOS: Civil engineering

description: In this lesson, students will explore and compare major religious landmarks in Senegal.  Students will also investigate how a building’s purpose can reflect artistic or design choices and how architecture and cultural practices can reflect or affect each other.
Covariate Selection in High-Dimensional Generalized Linear Models With Measurement Error
Creators: name: Sørensen, Øystein
name: Frigessi, Arnoldo
name: Thoresen, Magne
Publisher: name: arXiv
Year: 2014
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In many problems involving generalized linear models, the covariates are subject to measurement error. When the number of covariates p exceeds the sample size n, regularized methods like the lasso or Dantzig selector are required. Several recent papers have studied methods which correct for measurement error in the lasso or Dantzig selector for linear models in the p>n setting. We study a correction for generalized linear models based on Rosenbaum and Tsybakov's matrix uncertainty selector. By not requiring an estimate of the measurement error covariance matrix, this generalized matrix uncertainty selector has a great practical advantage in problems involving high-dimensional data. We further derive an alternative method based on the lasso, and develop efficient algorithms for both methods. In our simulation studies of logistic and Poisson regression with measurement error, the proposed methods outperform the standard lasso and Dantzig selector with respect to covariate selection, by reducing the number of false positives considerably. We also consider classification of patients on the basis of gene expression data with noisy measurements.
title: The elbow: Anatomy and Pathology of Collateral Ligaments using MRI.
Creators: name: Acosta Batlle, Jose
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Pathology
subject: Education
subject: MR
subject: Musculoskeletal joint

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To provide a comprehensive review of the normal anatomy and the biomechanics aspects of the medial and lateral collateral ligaments. 2. To highlight important technical aspects that optimise visualitation of anatomic structures. 3. To explain the...
The Kozai-Lidov Mechanism in Hydrodynamical Disks
Creators: name: Martin, Rebecca G.
name: Nixon, Chris
name: Lubow, Stephen H.
name: Armitage, Philip J.
name: Price, Daniel J.
name: Dogan, Suzan
name: King, Andrew
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We use three dimensional hydrodynamical simulations to show that a highly misaligned accretion disk around one component of a binary system can exhibit global Kozai-Lidov cycles, where the inclination and eccentricity of the disk are interchanged periodically. This has important implications for accreting systems on all scales, for example, the formation of planets and satellites in circumstellar and circumplanetary disks, outbursts in X-ray binary systems and accretion on to supermassive black holes.
description: Accepted for publication in ApJ Letters
Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors
Creators: name: Arrowsmith, Cheryl H.
name: Dong, Aiping
name: Schapira, Matthieu
name: Ma, Anqi
name: Jin, Jian
name: Liu, Jing
name: Liu, Feng
name: Vedadi, Masoud
name: Korboukh, Ilia
name: Frye, Stephen V.
name: Smil, David
name: Gao, Cen
name: Li, Fengling
name: Brown, Peter J.
name: Dobrovetsky, Elena
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the 40S ribosomal protein S2 and in cancer via interaction with the DAL-1 tumor suppressor protein. However, few selective inhibitors of PRMTs have been discovered. We recently disclosed the first selective PRMT3 inhibitor, which occupies a novel allosteric binding site and is noncompetitive with both the peptide substrate and cofactor. Here we report comprehensive structure-activity relationship studies of this series, which resulted in the discovery of multiple PRMT3 inhibitors with submicromolar potencies. An X-ray crystal structure of compound 14u in complex with PRMT3 confirmed that this inhibitor occupied the same allosteric binding site as our initial lead compound. These studies provide the first experimental evidence that potent and selective inhibitors can be created by exploiting the allosteric binding site of PRMT3.
Tools for incorporating a D-wave contribution in Skyrme energy density functionals
Creators: name: Becker, P.
name: Davesne, D.
name: Meyer, J.
name: Pastore, A.
name: Navarro, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The possibility of adding a D-wave term to the standard Skyrme effective interaction has been widely considered in the past. Such a term has been shown to appear in the next-to-next-to-leading order of the Skyrme pseudo-potential. The aim of the present article is to provide the necessary tools to incorporate this term in a fitting procedure: first, a mean-field equation written in spherical symmetry in order to describe spherical nuclei and second, the response function to detect unphysical instabilities. With these tools it will be possible to build a new fitting procedure to determine the coupling constants of the new functional.
Simultaneous isotyping and semi-quantitation of anti-drug antibodies to an IgG1 biotherapeutic using hybrid LBA-LC-MS/MS
Creators: name: Schalk, Frank B.
name: Guerrieri, Davide
name: Poetzl, Johann
name: van de Merbel, Nico C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Commonly, ligand-binding platforms are being used for immunogenicity assessment, but with the recent advent of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for protein quantification, this technology has become an alternative for the measurement of anti-drug antibodies (ADAs), when combined with an immunocapture step to extract them out of the biological sample. The monoclonal antibody adalimumab was immobilized on magnetic beads to isolate ADAs against this drug from serum samples. Multiple repetitions of immunopurification were used to minimize nonspecific binding and improve drug tolerance while maintaining sufficient recovery. A subsequent tryptic digestion released peptides, from which unique peptide sequences, originating from the constant region of seven ADA subclasses, were selected. These were then analyzed by LC-MS/MS against (unextracted) subclass-specific reference standards for semi-quantification. With two immunocapture and two immunopurification steps, the method simultaneously measures the ADA subclasses IgG1, IgG2, IgG3, IgG4, IgM, IgE and IgA within their relevant ranges, with good repeatability and drug tolerance, and limited interference of endogenous immunoglobulins. The method was successfully applied for the analysis of serum samples of subjects dosed with adalimumab. Hybrid LBA-LC-MS/MS is a viable platform for measuring ADAs and adds value, especially when ADA isotyping is needed.
Additional file 11 of Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes
Creators: name: Ueno, Masanobu
name: Miyagawa, Ippei
name: Miyazaki, Yusuke
name: Hanami, Kentaro
name: Fukuyo, Shunsuke
name: Kubo, Satoshi
name: Nakayamada, Shingo
name: Tanaka, Yoshiya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 11: Supplementary Table S6. Comparison of activated Th1 and Th17 between PPPASI-50/75/90 responder and non-responder in PAO. Data are shown by median(quartile). P values were determined by Wilcoxon rank sum test. p*<0.05: with PPPASI-50 responder (N = 14) vs non-responder (N = 7) at baseline, PPPASI-75 responder (N = 13) vs non-responder (N = 8) at baseline, PPPASI-90 responder (N = 12) vs non-responder (N = 9) at baseline, PPPASI-50/75 responder (N = 7) vs non-responder (N = 6) at 6 months, and PPPASI-90 responder (N = 6) vs non-responder (N = 7) at months 6.
Resonant Chains and Three-body Resonances in the Closely-Packed Inner Uranian Satellite System
Creators: name: Quillen, Alice C.
name: French, Robert S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Numerical integrations of the closely-packed inner Uranian satellite system show that variations in semi-major axes can take place simultaneously between three or four consecutive satellites. We find that the three-body Laplace angle values are distributed unevenly and have histograms showing structure, if the angle is associated with a resonant chain, with both pairs of bodies near first-order two-body resonances. Estimated three-body resonance libration frequencies can be only an order of magnitude lower than those of first-order resonances. Their strength arises from a small divisor from the distance to the first-order resonances and insensitivity to eccentricity, which make up for their dependence on moon mass. Three-body resonances associated with low-integer Laplace angles can also be comparatively strong due to the many multiples of the angle contributed from Fourier components of the interaction terms. We attribute small coupled variations in semi-major axis, seen throughout the simulation, to ubiquitous and weak three-body resonant couplings. We show that a system with two pairs of bodies in first-order mean-motion resonance can be transformed to resemble the well-studied periodically-forced pendulum with the frequency of a Laplace angle serving as a perturbation frequency. We identify trios of bodies and overlapping pairs of two-body resonances in each trio that have particularly short estimated Lyapunov timescales.
Additional file 12 of Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes
Creators: name: Ueno, Masanobu
name: Miyagawa, Ippei
name: Miyazaki, Yusuke
name: Hanami, Kentaro
name: Fukuyo, Shunsuke
name: Kubo, Satoshi
name: Nakayamada, Shingo
name: Tanaka, Yoshiya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 12: Supplementary Table S7. Comparison of baseline cytokine concentration and their decrease rates between guselkumab group (N = 5) and adalimumab group (N = 7). Data are shown by median(quartile). P values were determined by Wilcoxon rank sum test. p*<0.05: with Baseline serum cytokines: guselkumab group (N = 12) vs adalimumab group (N = 10), Decrease rates of cytokines: guselkumab group (N = 5) vs adalimumab group (N = 7). PsA; Psoriatic arthritis, PAO; pustulotic arthro-osteitis.
title: Transient Regional Bone Marrow Edema: A Rare Cause of Foot and Ankle Pain.
Creators: name: Acosta Batlle, Jose
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: MR
subject: Musculoskeletal bone
subject: Education
subject: Arthritides
subject: Athletic injuries
subject: Oedema

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the radiographic appearance of transient regional bone marrow edema syndrome of the foot and ankle, emphasizing those finding that may suggest the correct diagnosis. To distinguish other causes of foot and ankle pain, using clinical and...
On a Transform Method for the Efficient Computation of Conditional VaR (and VaR) with Application to Loss Models with Jumps and Stochastic Volatility
Creators: name: Ramponi, Alessandro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Risk Management (q-fin.RM)
subject: FOS: Economics and business
subject: 91G60, 91B30, 60E10

description: In this paper we consider Fourier transform techniques to efficiently compute the Value-at-Risk and the Conditional Value-at-Risk of an arbitrary loss random variable, characterized by having a computable generalized characteristic function. We exploit the property of these risk measures of being the solution of an elementary optimization problem of convex type in one dimension for which Fast and Fractional Fourier transform can be implemented. An application to univariate loss models driven by Lévy or stochastic volatility risk factors dynamic is finally reported.
description: 23 pages, 7 figures
Polyhedral analysis and branch and cut algorithms for some NP-hard spanning subgraph problems
Creators: name: Laureana, Federica
Publisher: name: Universita degli studi di Salerno
Year: 2020
Subjects: subject: MAT/09 RICERCA OPERATIVA
subject: Analisi poliedrale
subject: Branch vertices
subject: Branch and cut

description: 2018 - 2019
description: There is a widespread need to use a quantitative approach for the solution of decision problems that arise in many different areas of real life. The goal is to choose which decisions to take to manage a real system as efficiently as possible using mathematical tools. Operations Research provides a scientific basis to try to analyze and understand situations even with very complex structures and then use the gathered information to pre dict the behaviour of a system and improve the performance of the system itself. The analysis of a real problem occurs in two phases: the representation of the problem through a mathematical model and the development of efficient mathematical methods to determine an optimal solution of the problem or a good approximation of it. Therefore, the Operations Research is the science that deals with giving a unitary context to mathematical and computer science concepts and that starting from theoretical bases arrives at the construction of concrete models and their solution. .. [edited by Author]
title: CT imaging in complications of sinusitis
Creators: name: Regaña Feijoó, María José
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: eHealth
subject: Emergency
subject: Neuroradiology brain
subject: CT
subject: Diagnostic procedure
subject: Infection
subject: Inflammation
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The complications of sinusitis are an uncommon but extremely serious circumstance due to the importance of the anatomical structures that surround the paranasal sinuses: orbit, calotte and cranial cavity. Therefore, a review of these complications...
Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors
Creators: name: Zhou, Yingqiu
name: Wang, Xiaodong
name: Zhang, Weihe
name: Norris-Drouin, Jacqueline
name: Frye, Stephen V.
name: Lee, Minjung
name: Machius, Mischa
name: Hunter, Debra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer therapeutic target. A structure-based drug design approach using a pseudo-ring replacement strategy was developed and validated to discover a new family of pyridinepyrimidine analogs as potent Mer inhibitors. Through SAR studies, 10 (UNC2250) was identified as the lead compound for further investigation based on high selectivity against other kinases and good pharmacokinetic properties. When applied to live cells, 10 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with 10 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional anti-tumor activity. The results provide a rationale for further investigation of this compound for therapeutic application in patients with cancer.
title: Studies on Aedes and Anopheles mosquitoes at the molecular level of genetics
Creators: name: R. Gale, K.
Publisher: name: University of Liverpool Repository
Year: 2023

description: Section 1: Construction and screening of a genomic library for the mosquito Aedes aegypti (Diptera, culicidae). A genomic library has been constructed for this important vector of arboviral disease. Total genomic DNA and various classes of RNA from Ae. aegypti were used to screen this library. The results obtained indicate that this species has a short period interspersion pattern of repeated sequences. Transcription of these repeats could not be detected using total cytoplasmic RNA, hnRNA or mRNA as hybridisation probes. Section 2: Sequence organisation of ribosomal DNA in Aedes aegypti. The Aedes aegypti genomic library was used to isolate clones containing the intact ribosomal DNA (rDNA) repeat of this species. This has been restriction mapped and the transcribed regions have been identified. The rDNA repeat is 9.0 Kb in length and is present as approximately 500 head-to-tail tandemly repeated copies. A low level of intraspecies polymorphism of Ae. aegypti rDNA is evident. Two restriction polymorphisms have been identified within the rDNA repeat. Section 3: Analysis of ribosomal DNA variation within Ae. aegypti'and between closely related species. Four variant rDNA clones have been isolated. One of these' may contain the end of a tandem array of ribosomal genes. Another variant contains a duplication of rDNA within the internal transcribed spacer region of the ribosomal repeat. Sequence analysis of this clone has identified regions at the 3' end of the 18S rRNA gene of Ae. aegypti which show very strong homology with the corresponding regions in other species. Some repeated sequences have been identified downstream of the 18S rRNA gene in this clone. Preliminary analysis of the two other rDNA variants indicates that one contains a duplication or insertion of DNA in the 28S rRNA coding region and one contains non-transcribed spacer homologous sequences which are not associated with rRNA coding regions. Section 4: DNA probes for species identification of mosquitoes in the Anopheles gambiae complex. DNA sequences have been isolated which distinguish four of the morphologically identical members of the An. gambiae species complex. Two sequence classes were obtained. Class 1 homologues are highly reiterated in the genomes of An. arabiensis and An. merus, present in low copy number in An. melas and were not detected in An. gambiae s. s. Class 1 sequences are male specific in An. arabiensis. Class 2 homologues are highly reiterated in the genomes of An. merus and An. melas and present in low to middle copy number in An. gambiae s. s, and An. arabiensis. Sex specificity of Class 2 homologues does not occur in the species tested (An. gambiae s. s. and An. arabiensis). Hybridisation of these species specific DNA sequences to mosquitoes squashed directly onto nitrocellulose provides a simplified method of species identification.
The s-Process Enrichment of the Globular Clusters M4 and M22
Creators: name: Shingles, Luke J.
name: Karakas, Amanda I.
name: Hirschi, Raphael
name: Fishlock, Cherie K.
name: Yong, David
name: Da Costa, Gary S.
name: Marino, Anna F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the enrichment in elements produced by the slow neutron-capture process ($s$-process) in the globular clusters M4 (NGC 6121) and M22 (NGC 6656). Stars in M4 have homogeneous abundances of Fe and neutron-capture elements, but the entire cluster is enhanced in $s$-process elements (Sr, Y, Ba, Pb) relative to other clusters with a similar metallicity. In M22, two stellar groups exhibit different abundances of Fe and $s$-process elements. By subtracting the mean abundances of $s$-poor from $s$-rich stars, we derive $s$-process residuals or empirical $s$-process distributions for M4 and M22. We find that the $s$-process distribution in M22 is more weighted toward the heavy $s$-peak (Ba, La, Ce) and Pb than M4, which has been enriched mostly with light $s$-peak elements (Sr, Y, Zr). We construct simple chemical evolution models using yields from massive star models that include rotation, which dramatically increases $s$-process production at low metallicity. We show that our massive star models with rotation rates of up to 50\% of the critical (break-up) velocity and changes to the preferred $^{17}$O($α$,$γ$)$^{21}$Ne rate produce insufficient heavy $s$-elements and Pb to match the empirical distributions. For models that incorporate AGB yields, we find that intermediate-mass yields (with a $^{22}$Ne neutron source) alone do not reproduce the light-to-heavy $s$-element ratios for M4 and M22, and that a small contribution from models with a $^{13}$C pocket is required. With our assumption that $^{13}$C pockets form for initial masses below a transition range between 3.0 and 3.5 M$_\odot$, we match the light-to-heavy s-element ratio in the s-process residual of M22 and predict a minimum enrichment timescale of between 240 and 360 Myr. Our predicted value is consistent with the 300 Myr upper limit age difference between the two groups derived from isochrone fitting.
description: 13 pages. Accepted for publication in ApJ