cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: LIFE SPARC – action C10: transfer to other estuaries (Replicability & Transferability): sub report 1. Inventory and comparative study
Creators: name: Bi, Qilong
name: Vanlede, Joris
name: Mostaert, Frank
Publisher: name: Flanders Hydraulics Research
Year: 2021

description: The concept of combining Flood Control Areas (FCA) and Areas with a Controlled Reduced Tide (CRT) to give “Space to the River” is an original idea that has been developed, implemented and monitored in a pilot project in Flanders, Belgium. Through years of development, this nature-based solution is proved to be an effective approach of providing protection against flooding and improving resilience of the estuary ecosystem under the threat of climate change.One of the important goals in the LIFE-SPARC project is to perform knowledge transfer of the FCA/CRT method, including the design methodology, the expected effects and the monitoring plan with European partners. This report is aligned with the LIFE-SPARC project Action C10: Transfer to other estuaries (Replicability & Transferability). This action aims to assess the applicability of the core concept in other European Estuaries.In the LIFE-SPARC project, an idealised modelling approach is proposed as a tool for assessing the applicability for six European estuaries. This approach requires schematization of the geometry and the measures in each estuary, and only the important physical processes will be considered.As the first step of the comparative study, this report focuses on the schematization of estuary geometry. The necessary data consisting of the characteristics of each estuary has been collected and analysed. The representative geometry of each estuary is derived and will be used in the idealised modelling later.
description: Title : FHR reports. Flanders Hydraulics Research: Antwerp Volume : 16_072_1 Issue : Pagination : VIII, 40 + 8 p. app.
Study on Health and Husbandry Practices of Achhami Cattle in Farwestern NepalStudy on Health and Husbandry Practices of Achhami Cattle in Farwestern Region of Nepal
Creators: name: Yagya Raj Pandeya
name: Shivahari Ghimire
name: Sanjit Niraula
Publisher: name: figshare
Year: 2020
Subjects: subject: 70203 Animal Management
subject: FOS: Animal and dairy science

description: Health and Husbandry Practices adopted by Achhami cattle rearing Farmers in Farwestern Nepal.
Information Geometric Perspective on Off-Resonance Effects in Driven Two-Level Quantum Systems
Creators: name: Cafaro, Carlo
name: Gassner, Steven
name: Alsing, Paul M.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present an information geometric analysis of off-resonance effects on classes of exactly solvable generalized semi-classical Rabi systems. Specifically, we consider population transfer performed by four distinct off-resonant driving schemes specified by su(2; C) time-dependent Hamiltonian models. For each scheme, we study the consequences of a departure from the on-resonance condition in terms of both geodesic paths and geodesic speeds on the corresponding manifold of transition probability vectors. In particular, we analyze the robustness of each driving scheme against off-resonance effects. Moreover, we report on a possible tradeoff between speed and robustness in the driving schemes being investigated. Finally, we discuss the emergence of a different relative ranking in terms of performance among the various driving schemes when transitioning from on-resonant to off-resonant scenarios.
description: 20 pages, 5 figures, feature paper
Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs
Creators: name: Bernardes, Nuno
name: Garizo, Ana Rita
name: Pinto, Sandra N.
name: Caniço, Bernardo
name: Perdigão, Catarina
name: Fernandes, Fábio
name: Fialho, Arsenio M.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Membrane lipid rafts are highly ordered microdomains and essential components of plasma membranes. In this work, we demonstrate that azurin uptake by cancer cells is, in part, mediated by caveolin-1 and GM-1, lipid rafts’ markers. This recognition is mediated by a surface exposed hydrophobic core displayed by azurin since the substitution of a phenylalanine residue in position 114 facing the hydrophobic cavity by alanine impacts such interactions, debilitating the uptake of azurin by cancer cells. Treating of cancer cells with azurin leads to a sequence of events: alters the lipid raft exposure at plasma membranes, causes a decrease in the plasma membrane order as examined by Laurdan two-photon imaging and leads to a decrease in the levels of caveolin-1. Caveolae, a subset of lipid rafts characterized by the presence of caveolin-1, are gaining increasing recognition as mediators in tumor progression and resistance to standard therapies. We show that azurin inhibits growth of cancer cells expressing caveolin-1, and this inhibition is only partially observed with mutant azurin. Finally, the simultaneous administration of azurin with anticancer therapeutic drugs (paclitaxel and doxorubicin) results in an enhancement in their activity, contrary to the mutated protein.
Phaulernis laserinella Nel 2003
Creators: name: Huemer, Peter
name: Van Nieukerken, Erik J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Epermeniidae
Phaulernis
Phaulernis laserinella

description: Phaulernis laserinella Nel, 2003
 Phaulernis laserinella Nel 2003b: 51, figs. 11–12, 14.
 Examined material. Paratype Ƌ: France, Vaucluse, Rochers des Rams, 1100 m, Mont Ventoux, 17.VI.2000, genitalia slide JN n°11465, J. Nel leg. (TLMF). Paratype Ƌ, idem, genitalia slide JN n°14594 (TLMF).
Paratype: BOLD Specimen ID TLMF 06873; BOLD Sequence ID PHLAG479-12. Paratype: BOLD Specimen ID TLMF 06874; BOLD Sequence ID PHLAG480-12.
BIN: BOLD:ABW1117
 Identity: Phaulernis laserinella Nel, 2003
 Remarks. Phaulernis laserinella was described from five males and a single female and compared with P. statariella (Heyden, 1863) (Nel 2003). Two successfully sequenced paratypes are ca. 5% divergent from this species and undoubtedly depict a different species.
description: Published as part of Huemer, Peter & Van Nieukerken, Erik J., 2021, Identity of some recently described Lepidoptera from France-re-assessed with DNA barcodes and morphology, pp. 301-337 in Zootaxa 4941 (3) on page 332, DOI: 10.11646/zootaxa.4941.3.1, http://zenodo.org/record/4595123
Modified ARCA analogs providing enhanced translational properties of capped mRNAs
Creators: name: Kocmik, Ilona
name: Piecyk, Karolina
name: Rudzinska, Magdalena
name: Niedzwiecka, Anna
name: Darzynkiewicz, Edward
name: Grzela, Renata
name: Jankowska-Anyszka, Marzena
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Nowadays gene manipulation techniques (“DNA therapy”) undergo progressive development and become widely used in industry and medicine. Since new advances in mRNA technologies are capable for obtaining particles with increased stability and translational efficiency, RNA become an attractive alternative for advancement of DNA therapy. For the past years studies have been conducted to explore different modification in mRNA cap structure and its effect on RNA properties. Recently we have shown that modification of the cap structure at the N2 position of 7-methylguanosine leads to an enhancement in translation inhibition. Currently, we have decided to exploit translational properties of mRNA capped with the ARCA (anti-reversed cap) analogs modified within N2 position of purine moiety s. We designed and synthesized three new dinucleotide cap analogs and investigated them in the rabbit reticulocyte lysate (RRL) and the human embryonic kidney derived HEK293 cell line, in vitro translational model systems. The obtained data indicate that, in both translational assays, the cap analogs synthesized by us when incorporated into mRNA improved its translational properties compared to the ARCA capped transcripts. Furthermore, the introduced modifications enhanced stability of the capped transcripts in HEK293 cells, which become higher compared to that of the transcripts capped with regular cap or with ARCA. Additionally one of the synthesized cap analogs revealed strong translation inhibition potency in RRL system, with IC50 value 1.7 µM.
A Non-Linear Magnetic Field Calibration Method for Filter-Based Magnetographs by Multilayer Perceptron
Creators: name: Guo, JingJing
name: Bai, XianYong
name: Deng, YuanYong
name: Liu, Hui
name: Lin, JiaBen
name: Su, JiangTao
name: Yang, Xiao
name: Ji, KaiFan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: For filter-based magnetographs, the linear calibration method under the weak-field assumption is usually adopted; this leads to magnetic saturation effect in the regions with strong magnetic field. This article explores a new method to overcome the above disadvantage using a multilayer perceptron network, which we call MagMLP, based on a back-propagation algorithm with one input layer, five hidden layers, and one output layer. We use the data from the \textit{Spectropolarimeter} (SP) on board \textit{Hinode} to simulate single-wavelength observations for the model training, and take into account the influence of the Doppler velocity field and the filling factor. The training results show that the linear fitting coefficient (LFC) of the transverse field reaches above 0.91, and that of the longitudinal field is above 0.98. The generalization of the models is good because the corresponding LFCs are above 0.9 for the test subsets. Compared with the linear calibration method, the MagMLP is much more effective on dealing with the magnetic saturation effect. Analyzing an active region, the results of the linear calibration present an evident magnetic saturation effect in the umbra regions; the corresponding systematic error reaches values greater than 1000 G in most areas, or even exceeds 2000 G at some pixels. However, the results of MagMLP at these locations are very close to the inversion results, and the systematic errors are basically within 300 G. In addition, we find that there are many "bright spots" and "dark spots" on the inclination angle images from the inversion results of \textit{Hinode}/SP with values of 180 and 0 degrees, respectively, where the inversion is not reliable and does not produce a good result; the MagMLP handles these points well.
description: 19 pages, 12 figures, 2 tables, accepted for publication in Solar Physics
ENFERMEDADES BACTERIANAS DEL TIQUISQUE (Xanthosoma spp.) EN COSTA RICA
Creators: name: Laguna, Irma
name: Salazar, Luis
name: López, Fernando
name: Laguna, Irma
name: Salazar, Luis
name: López, Fernando
Publisher: name: Unknown
Year: 1983
Subjects: Crop Production/Industries
Research and Development/Tech Change/Emerging Technologies

description: El cultivo del tiquisque (Xanthosoma spp) está adquiriendo mayor importancia en Costa Rica en los últimos años, siendo las especies utilizadas el tiquisque blanco (X. sagittifolium Schott) y el tiquisque morado (X. violaceum). En las áreas productoras se han detectado dos-enfermedades bacterianas, Mancha bacteriana: causada por Xanthomonas campestris p. v. aracearum (Berniac)Dye, cuyos síntomas se manifiestan como manchas clor6ticas pequeñas y abundantes que pueden cubrir toda la superficie foliar. Esta enfermedad se presenta en la región Atlántica. En algunas de las localidades observadas se ha registrado una incidencia que alcanza el 90%. Necrosis marginal bacteriana: causada por Xanthomonas campestris (Pammel) Dowson, cuya infección comienza como una necrosis en los márgenes de las hojas que va avanzando hacia el interior de la lámina y puede continuar necrosando las nervaduras y posteriormente los pecfolos. Esta enfermedad está distribuida en todas las áreas donde se cultiva tiquisque en Costa Rica. ----- During the last years, cocoyam crops have acquired more importance in Costa Rica. The species used are white cocoyam (Xanthosoma sagittifolium Schott) and purple cocoyam (Xanthosoma violaceum). In the production areas two diseases have been detected. Bacterial Spot: caused by Xanthomonas campestris p.v. aracearum (Berniac) Dye. Symptoms were shown as abundant small clorotic spots that can cover all of the foliar area. This disease is present only in the Atlantic Zone (Limôn), and in some places an incidence of almost 90% has been observed. Bacterial Necrotic Margin: caused by Xanthomonas campestris (Pammel) Dowson. The infection starts like a necrosis on the edge of the leaves, and it continues to the interior of them. It can keep necrosising the nervures and later the petioles. This disease is spread in all the areas of Costa Rica that grow cocoyam. Morfological, physiological, and pathogenic testings were made in both diseases for their identification.
Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs
Creators: name: Bernardes, Nuno
name: Garizo, Ana Rita
name: Pinto, Sandra N
name: Caniço, Bernardo
name: Perdigão, Catarina
name: Fernandes, Fábio
name: Fialho, Arsenio M
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Membrane lipid rafts are highly ordered microdomains and essential components of plasma membranes. In this work, we demonstrate that azurin uptake by cancer cells is, in part, mediated by caveolin-1 and GM-1, lipid rafts’ markers. This recognition is mediated by a surface exposed hydrophobic core displayed by azurin since the substitution of a phenylalanine residue in position 114 facing the hydrophobic cavity by alanine impacts such interactions, debilitating the uptake of azurin by cancer cells. Treating of cancer cells with azurin leads to a sequence of events: alters the lipid raft exposure at plasma membranes, causes a decrease in the plasma membrane order as examined by Laurdan two-photon imaging and leads to a decrease in the levels of caveolin-1. Caveolae, a subset of lipid rafts characterized by the presence of caveolin-1, are gaining increasing recognition as mediators in tumor progression and resistance to standard therapies. We show that azurin inhibits growth of cancer cells expressing caveolin-1, and this inhibition is only partially observed with mutant azurin. Finally, the simultaneous administration of azurin with anticancer therapeutic drugs (paclitaxel and doxorubicin) results in an enhancement in their activity, contrary to the mutated protein.
Technology Acceptance Model (TAM) As a Predictor Model for Explaining Agricultural Experts Behavior in Acceptance of ICT
Creators: name: Alambaigi, Amir
name: Ahangari, Ismael
name: Alambaigi, Amir
name: Ahangari, Ismael
Publisher: name: Unknown
Year: 2016
Subjects: subject: Research and Development/Tech Change/Emerging Technologies
subject: Teaching/Communication/Extension/Profession
subject: Technology acceptance model
subject: Job relevance
subject: IT
subject: Partial least squares

description: This study aimed to develop Technology Acceptance Model (TAM) model to explain adoption of information technologies process. a Descriptive – correlation study was conducted and data were collected through a survey. Statistical population was West Azerbaijan Agricultural Extension agents who 120 of them were selected randomly using the Krejcie and Morgan table. A questionnaire was employed to measure the variables in the model. Its validity was confirmed by a panel of experts. The Cronbach's alpha coefficient ranged between from 0.704 to 0.816 show satisfied reliability. For data processing, partial least squares (PLS) method as a new approach to structural equation modeling was used. The results showed that among three variables for development of technology acceptance model including Job relevance, experience and organization willingness to invest, the first and second show significant effects. Thus, Job relevance and experience as an external variable was added to the basic TAM. Other relations between variables in basic technology acceptance model in current study were also seen significant. Our developed TAM can explain 64% of the actual behavior of employee in information technology utilization. TAM is one of the most influential extensions of Ajzen and Fishbein’s theory of reasoned action (TRA) in the literature. The theories behind it assume that when a person forms an intention to act, that s/he will be free to act without limitation. While In the real world there will be many constraints, such as limited freedom to act. For example, people in organized working environments are forced to use most of the relevant applications irrespective of their opinion or attitude. In this research mentioned model was used as a strong model to predict actual use behavior that affected by three variables namely Job relevance, experience and organization willingness to invest.
Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model
Creators: name: Simone, Brittany A.
name: Palagani, Ajay
name: Strickland, Kimberly
name: Ko, Kevin
name: Jin, Lianjin
name: Lim, Meng Kieng
name: Dan, Tu D.
name: Sarich, Mak
name: Monti, Daniel A.
name: Cristofanilli, Massimo
name: Simone, Nicole L.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Triple negative breast cancer (TNBC) is a heterogeneous disease that has no available targeted therapies. Previously, we have shown that caloric restriction (CR) can augment the effects of radiation therapy in a TNBC mouse model. To build upon this, we now present data regarding the combination of chemotherapy and CR in the same 4T1 model. Chemotherapy can induce inflammation that breeds resistance to therapy. We propose CR as a mechanism to decrease chemotherapy-induced inflammation and increase efficacy of therapy. 12-week old Balb/c mice were orthotopically injected with a syngeneic triple negative breast cancer cell line (4T1) and were treated in one of six cohorts: ad lib fed (AL), 30% reduction in calorie intake (CR), cisplatin or docetaxol alone or a combination CR+cisplatin/docetaxol. Mice in the cohorts receiving chemotherapy+CR had longer overall survival (12 ± 2 days) as compared to the AL group. These mice also demonstrated less lung metastases at the final time point of in vivo imaging. In addition, downregulation of the IGF-1R and IRS signaling pathways were noted most significantly in those mice receiving combination therapy. Lastly, serum from these mice demonstrated an increase in inflammatory cytokines TNF-α and IL-1β in response to chemotherapy alone. This increase was dampened by the addition of CR. Taken together, these data suggest that while chemotherapy is effective in TNBC, it can cause inflammation, which can be a driver of resistance to therapy. This chemotherapy-induced inflammation can be reversed with the use of CR as a nontoxic adjunct to treatment.
Eigenmode Analysis of Galaxy Distributions in Redshift Space
Creators: name: Matsubara, Takahiko
name: Szalay, Alexander S.
name: Pope, Adrian C.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Eigenmode analysis is one of the most promising methods of analyzing large data sets in ongoing and near-future galaxy surveys. In such analyses, a fast evaluation of the correlation matrix in arbitrary cosmological models is crucial. The observational effects, including peculiar velocity distortions in redshift space, light-cone effects, selection effects, and effects of the complex shape of the survey geometry, should be taken into account in the analysis. In the framework of the linear theory of gravitational instability, we provide the methodology to quickly compute the correlation matrix. Our methods are not restricted to shallow redshift surveys, arbitrarily deep samples can be dealt with as well. Therefore, our methods are useful in constraining the geometry of the universe and the dark energy component, as well as the power spectrum of galaxies, since ongoing and near-future galaxy surveys probe the universe at intermediate to deep redshifts, z ~ 0.2--5. In addition to the detailed methods to compute the correlation matrix in 3-dimensional redshift surveys, methods to calculate the matrix in 2-dimensional projected samples are also provided. Prospects of applying our methods to likelihood estimation of the cosmological parameters are discussed.
description: Submitted to ApJ
Marketing Strategies for Organic Products in Iran
Creators: name: Mohammadian, Mahmoud
name: Dadashi, Mohammad Ali
name: Mohammadian, Mahmoud
name: Dadashi, Mohammad Ali
Publisher: name: Unknown
Year: 2016
Subjects: subject: Crop Production/Industries
subject: International Relations/Trade
subject: Marketing
subject: FOS: Economics and business
subject: Iran
subject: Marketing strategy
subject: Sustainable competition
subject: Organic products

description: The strategic planning of marketing and the application of marketing strategies for achieving sustainable competitive advantages are of the factors that help the survival of producers of agricultural organic products. Although, there are evidences of the growth of organic farming in Iran but, there are no useful information and proposals for making marketing strategies in organic production holdings for producers and traders. For this, we assessed the influence of three effective elements include marketing approach, pricing and the sale of organic products in Iran. The study was based on the factor analysis, explorative interview and structured questionnaire. The study population was composed of 20 experienced experts and 118 organic agricultural producers from the various regions include Tehran, Khorasan-e-Razavi, Guilan, Khoozestan, Kerman, Kordestan, Qazvin and Isfahan for the periode of Jan 2014 to June 2015. It was found out that the main barriers to the development of organic products and their markets include inappropriate packaging, high transportation costs, the lack of unit manager and inconsistent strategy, market-making and customer-orientation, weak public advertisement, the lack of trust to organic brands at national level, and weak state support.
Ireland's Ocean Economy
Creators: name: Vega, Amaya
name: Hynes, Stephen
name: Vega, Amaya
name: Hynes, Stephen
Publisher: name: Unknown
Year: 2017
Subjects: subject: Environmental Economics and Policy
subject: Political Economy
subject: Productivity Analysis
subject: Public Economics
subject: Resource /Energy Economics and Policy
subject: Marine
subject: Ocean
subject: Economy
subject: Ireland

description: Marine socio-economic data are not readily available in Ireland. However, they are essential in determining the value of Ireland’s ocean economy, so as to realise its full potential. SEMRU began the extensive task of data collection and analysis of Ireland’s ocean economy in 2009. This resulted in the publication of a series of bi-annual ocean economy reports, to which, this report is the latest addition. The report provides a quantification and realistic monitoring of Ireland’s ocean economy over time and presents a complete and comparable sectoral profile across the ocean economy, which allows us to observe progress on the targets set out in the Government’s Integrated Marine Plan for Ireland - Harnessing Our Ocean Wealth (2012). The reference year for this report is 2014. The report includes a set of economic projections that forecast Ireland’s ocean economy up to 2016. For the first time, this report includes a full 2008-2016 data series illustrating Ireland’s ocean economic performance and trends over an eight-year period.
description: Report published 2017, using actual 2014 figures and estimates for 2015 and 2016.
Pair creation of de Sitter black holes on a cosmic string background
Creators: name: Dias, Oscar J. C.
name: Lemos, Jose' P. S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We analyze the quantum process in which a cosmic string breaks in a de Sitter (dS) background, and a pair of neutral or charged black holes is produced at the ends of the string. The energy to materialize and accelerate the pair comes from the positive cosmological constant and, in addition, from the string tension. The compact saddle point solutions without conical singularities (instantons) or with conical singularities (sub-maximal instantons) that describe this process are constructed through the analytical continuation of the dS C-metric. Then, we explicitly compute the pair creation rate of the process. In particular, we find the nucleation rate of a cosmic string in a dS background, and the probability that it breaks and a pair of black holes is produced. Finally we verify that, as occurs with pair production processes in other background fields, the pair creation rate of black holes is proportional to exp(S), where the gravitational entropy of the black hole, S, is given by one quarter of the area of the horizons present in the saddle point solution that mediates the process.
description: 20 pages, 4 figures, RevTex4. Physical discussion of the results highly improved. References added. Published version
Carbon on the nanoscale: Ultrastiffness and unambiguous definition of incompressibility
Creators: name: Khabibrakhmanov, Almaz
name: Sorokin, Pavel
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In the presented work, the features of mechanical stiffness of carbon nanoparticles (nanodiamonds and fullerenes) in a wide range of sizes are considered. The enhancement of nanodiamonds stiffness (comparing to bulk diamond) is studied and explained in the terms of average bond stiffness $k_0$. It is shown that $k_0$ can be useful in the description of various carbon nanostructures and gives reliable estimates of their incompressibility. Moreover, we found that $k_0$ can be well estimated based only on relaxed atomic geometry.
Parallel reduction in expression, but no loss of functional constraint, in two opsin paralogs within cave populations of Gammarus minus (Crustacea : Amphipoda)
Creators: name: Fong, Daniel
name: Carlini, David
name: Satish, Suma
Publisher: name: BMC Evolutionary Biology
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Background: Gammarus minus, a freshwater amphipod living in the cave and surface streams in the eastern USA, is a premier candidate for studying the evolution of troglomorphic traits such as pigmentation loss, elongated appendages, and reduced eyes. In G. minus, multiple pairs of genetically related, physically proximate cave and surface populations exist which exhibit a high degree of intraspecific morphological divergence. The morphology, ecology, and genetic structure of these sister populations are well characterized, yet the genetic basis of their morphological divergence remains unknown.Results: We used degenerate PCR primers designed to amplify opsin genes within the subphylum Crustacea and discovered two distinct opsin paralogs (average inter-paralog protein divergence approximate to 20%) in the genome of three independently derived pairs of G. minus cave and surface populations. Both opsin paralogs were found to be related to other crustacean middle wavelength sensitive opsins. Low levels of nucleotide sequence variation (< 1% within populations) were detected in both opsin genes, regardless of habitat, and dN/dS ratios did not indicate a relaxation of functional constraint in the cave populations with reduced or absent eyes. Maximum likelihood analyses using codon-based models also did not detect a relaxation of functional constraint in the cave lineages. We quantified expression level of both opsin genes and found that the expression of both paralogs was significantly reduced in all three cave populations relative to their sister surface populations.Conclusions: The concordantly lowered expression level of both opsin genes in cave populations of G. minus compared to sister surface populations, combined with evidence for persistent purifying selection in the cave populations, is consistent with an unspecified pleiotropic function of opsin proteins. Our results indicate that phototransduction proteins such as opsins may have retained their function in cave-adapted organisms because they may play a pleiotropic role in other important processes that are unrelated to vision.
Parametric Amplification of Broadband Vibrational Energy Harvesters for Energy-Autonomous Sensors Enabled by Field-Induced Striction
Creators: name: Nabholz, Ulrike
name: Lamprecht, Lukas
name: Mehner, Jan E.
name: Zimmermann, André
name: Degenfeld-Schonburg, Peter
Publisher: name: arXiv
Year: 2020
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We investigate the influence of parametric excitation on MEMS vibration energy harvesters for energy autonomous sensor systems. In Industry 4.0 (or Industrial IoT) applications, interconnected sensors provide a means of data acquisition for automated control of the manufacturing process. Ensuring a continuous energy supply to the sensors is essential for their reliable operation. Manufacturing machines usually display a wide spectrum of vibration frequencies which needs to be covered by an array of harvester substructures in order to maintain the desired output level. We show that mechanical structures designed to implement a Helmholtz-Duffing oscillator have an increased bandwidth by exploiting several orders of parametric resonances. In contrast to concepts implementing parametric amplification in a multi-mode scenario, our concept is based on a single mechanical mode. Therefore, it is more robust against fabrication tolerances as the relevant multi-mode resonance conditions do not need to be matched on the level of single chips. Using exact transient simulations and semi-analytic models to showcase the relation of the Helmholtz-Duffing oscillator to the damped and driven Mathieu equation, we show that parametric resonances highly increase the bandwidth of the output power whenever high Helmholtz nonlinearities are present. To achieve the required nonlinearities, we suggest nonlinear stress-strain curves and we propose to achieve such nonlinearities through field-induced striction by magneto- or electrostriction. Thus, we are able to propose a novel energy harvester concept incorporating strictive materials that exploits the effects of parametric excitation to achieve broadband vibrational energy harvesting.
description: Copyright 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Awareness, perception and experience on child restraint system (CRS) and its legislation among Malaysian parents with newborns
Creators: name: Ang, Ju-Ying
name: Lai, Jia-Min
name: Amar-Singh Hss
name: Ramalingam, Pallavi
name: Mugelaa Ramasamy
name: Nur-Safrina Zainuddin
name: Hanisah Shaari
name: Aznany Ahmad-Aduan
name: Nur-Shafika Sanimi
name: Norlela Bahari
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: The aim of this study was to explore parents’ awareness and usage of CRS, incentives and challenges in CRS use, as well as their perception about potential CRS legislation in Malaysia. Methods: This was a cross-sectional study conducted in a public tertiary care center in Northern Malaysia. A self-developed researcher-assisted questionnaire was developed in English and translated into Malay language, to explore parents’ awareness ad CRS usage, as well as the incentives and barriers in CRS use. Parents of a newborn were conveniently sampled, excluding parents with pre-term newborn or those without a car. Upon obtaining written informed consent, the parents were allowed to answer the questionnaire within 20 minutes, assisted by the researchers. Parents who were found not using CRS for their newborn were given a digital pamphlet with CRS-related information via mobile devices. Results: A total of 200 parents were approached and 193 of them consented to participate in this study. The majority of the parents (87.6%) were aware of CRS, but only half of them (57.0%) provided a CRS for their current newborn. From 100 CRS users, most of them used a CRS for “child’s safety” purposes (84.5%). Among 83 CRS nonuser, nearly half of them (45.8%) perceived that it is adequate to carry their child during traveling without using a CRS. When exploring previous experience in using CRS among all parents (n = 193), more than half of them (63.9%) faced difficulty as their child refused to use the CRS. More than half (54.9%) of all parents were not aware about the possible CRS legislation in Malaysia. However, the majority of them (90.7%) agreed with the implementation of CRS law. Conclusions: Although majority of the parents were aware about CRS, but only half had a CRS for their current newborn. Most of the parents supported CRS legislation in Malaysia, but assistance will be required to help them through challenges related to CRS use.
Epermenia pumila
Creators: name: Huemer, Peter
name: Van Nieukerken, Erik J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Epermeniidae
Epermenia
Epermenia pumila

description: Epermenia pumila (Buvat & Nel, 2000)
 Cataplectica pumila Buvat & Nel 2000: 96, figs. 4–5.
 Examined material. Ƌ: France, Rhone-Alpes, Les Houche, 1800 m, 28 julliet 2005, genitalia slide JN 21582, J. Nel leg. (TLMF).
BOLD Specimen ID TLMF 06872; BOLD Sequence ID PHLAG478-12.
BIN: BOLD:AAL0674
 Identity: Epermenia profugella (Stainton, 1856), syn. nov. (Fig. 12)
 Remarks. Epermenia pumila was described from a male specimen collected in 1948 in the Alpes-Maritimes (Buvat & Nel 2000). We have not been able to examine the holotype, but examined a second specimen identified as E. pumila by J. Nel which fully corresponds to the original description. This specimen agrees both morphologically and in the DNA barcode with E. profugella (Stainton, 1856) and E. pumila is therefore synonymized with that species.
description: Published as part of Huemer, Peter & Van Nieukerken, Erik J., 2021, Identity of some recently described Lepidoptera from France-re-assessed with DNA barcodes and morphology, pp. 301-337 in Zootaxa 4941 (3) on page 332, DOI: 10.11646/zootaxa.4941.3.1, http://zenodo.org/record/4595123
Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model
Creators: name: Simone, Brittany A.
name: Palagani, Ajay
name: Strickland, Kimberly
name: Ko, Kevin
name: Jin, Lianjin
name: Lim, Meng Kieng
name: Dan, Tu D.
name: Sarich, Mak
name: A. Monti, Daniel
name: Cristofanilli, Massimo
name: L. Simone, Nicole
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Triple negative breast cancer (TNBC) is a heterogeneous disease that has no available targeted therapies. Previously, we have shown that caloric restriction (CR) can augment the effects of radiation therapy in a TNBC mouse model. To build upon this, we now present data regarding the combination of chemotherapy and CR in the same 4T1 model. Chemotherapy can induce inflammation that breeds resistance to therapy. We propose CR as a mechanism to decrease chemotherapy-induced inflammation and increase efficacy of therapy. 12-week old Balb/c mice were orthotopically injected with a syngeneic triple negative breast cancer cell line (4T1) and were treated in one of six cohorts: ad lib fed (AL), 30% reduction in calorie intake (CR), cisplatin or docetaxol alone or a combination CR+cisplatin/docetaxol. Mice in the cohorts receiving chemotherapy+CR had longer overall survival (12 ± 2 days) as compared to the AL group. These mice also demonstrated less lung metastases at the final time point of in vivo imaging. In addition, downregulation of the IGF-1R and IRS signaling pathways were noted most significantly in those mice receiving combination therapy. Lastly, serum from these mice demonstrated an increase in inflammatory cytokines TNF-α and IL-1β in response to chemotherapy alone. This increase was dampened by the addition of CR. Taken together, these data suggest that while chemotherapy is effective in TNBC, it can cause inflammation, which can be a driver of resistance to therapy. This chemotherapy-induced inflammation can be reversed with the use of CR as a nontoxic adjunct to treatment.
Walking fingerprinting
Creators: name: Koffman, Lily
name: Crainiceanu, Ciprian
name: Leroux, Andrew
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applications (stat.AP)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We consider the problem of predicting an individual's identity from accelerometry data collected during walking. In a previous paper we introduced an approach that transforms the accelerometry time series into an image by constructing its complete empirical autocorrelation distribution. Predictors derived by partitioning this image into grid cells were used in logistic regression to predict individuals. Here we: (1) implement machine learning methods for prediction using the grid cell-derived predictors; (2) derive inferential methods to screen for the most predictive grid cells; and (3) develop a novel multivariate functional regression model that avoids partitioning of the predictor space into cells. Prediction methods are compared on two open source data sets: (1) accelerometry data collected from $32$ individuals walking on a $1.06$ kilometer path; and (2) accelerometry data collected from six repetitions of walking on a $20$ meter path on two separate occasions at least one week apart for $153$ study participants. In the $32$-individual study, all methods achieve at least $95$% rank-1 accuracy, while in the $153$-individual study, accuracy varies from $41$% to $98$%, depending on the method and prediction task. Methods provide insights into why some individuals are easier to predict than others.
description: 37 pages, 6 figures, 2 tables. Submitted to Journal of the American Statistical Association
Spatial and null infinity via advanced and retarded conformal factors
Creators: name: Hayward, Sean A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A new approach to space-time asymptotics is presented, refining Penrose's idea of conformal transformations with infinity represented by the conformal boundary of space-time. Generalizing examples such as flat and Schwarzschild space-times, it is proposed that the Penrose conformal factor be a product of advanced and retarded conformal factors, which asymptotically relate physical and conformal null (light-like) coordinates and vanish at future and past null infinity respectively, with both vanishing at spatial infinity. A correspondingly refined definition of asymptotic flatness at both spatial and null infinity is given, including that the conformal boundary is locally a light cone, with spatial infinity as the vertex. It is shown how to choose the conformal factors so that this asymptotic light cone is locally a metric light cone. The theory is implemented in the spin-coefficient (or null-tetrad) formalism by a simple joint transformation of the spin-metric and spin-basis (or metric and tetrad). The advanced and retarded conformal factors may be used as expansion parameters near the respective null infinity, together with a dependent expansion parameter for both spatial and null infinity, essentially inverse radius. Asymptotic regularity conditions on the spin-coefficients are proposed, based on the conformal boundary locally being a smoothly embedded metric light cone. These conditions ensure that the Bondi-Sachs energy-flux integrals of ingoing and outgoing gravitational radiation decay at spatial infinity such that the total radiated energy is finite, and that the Bondi-Sachs energy-momentum has a unique limit at spatial infinity, coinciding with the uniquely rendered ADM energy-momentum.
description: 11 revtex4 pages, 1 eps figure, correcting typos etc, unabridged (abridged version to be published)
Parallel reduction in expression, but no loss of functional constraint, in two opsin paralogs within cave populations of Gammarus minus (Crustacea : Amphipoda)
Creators: name: Fong, Daniel
name: Carlini, David
name: Satish, Suma
Publisher: name: American University
Year: 2023

description: Background: Gammarus minus, a freshwater amphipod living in the cave and surface streams in the eastern USA, is a premier candidate for studying the evolution of troglomorphic traits such as pigmentation loss, elongated appendages, and reduced eyes. In G. minus, multiple pairs of genetically related, physically proximate cave and surface populations exist which exhibit a high degree of intraspecific morphological divergence. The morphology, ecology, and genetic structure of these sister populations are well characterized, yet the genetic basis of their morphological divergence remains unknown.Results: We used degenerate PCR primers designed to amplify opsin genes within the subphylum Crustacea and discovered two distinct opsin paralogs (average inter-paralog protein divergence approximate to 20%) in the genome of three independently derived pairs of G. minus cave and surface populations. Both opsin paralogs were found to be related to other crustacean middle wavelength sensitive opsins. Low levels of nucleotide sequence variation (< 1% within populations) were detected in both opsin genes, regardless of habitat, and dN/dS ratios did not indicate a relaxation of functional constraint in the cave populations with reduced or absent eyes. Maximum likelihood analyses using codon-based models also did not detect a relaxation of functional constraint in the cave lineages. We quantified expression level of both opsin genes and found that the expression of both paralogs was significantly reduced in all three cave populations relative to their sister surface populations.Conclusions: The concordantly lowered expression level of both opsin genes in cave populations of G. minus compared to sister surface populations, combined with evidence for persistent purifying selection in the cave populations, is consistent with an unspecified pleiotropic function of opsin proteins. Our results indicate that phototransduction proteins such as opsins may have retained their function in cave-adapted organisms because they may play a pleiotropic role in other important processes that are unrelated to vision.
Magnetorotational Instability in Diamagnetic, Misaligned Protostellar Discs
Creators: name: Devlen, Ebru
name: Ulubay, Ayse
name: Pekünlü, E. Rennan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: In the present study, we addressed the question of how the growth rate of the magnetorotational instability is modified when the radial component of the stellar dipole magnetic field is taken into account in addition to the vertical component. Considering a fiducial radius in the disc where diamagnetic currents are pronounced, we carried out a linear stability analysis to obtain the growth rates of the magnetorotational instability for various parameters such as the ratio of the radial-to-vertical component and the gradient of the magnetic field, the Alfvenic Mach number and the diamagnetization parameter. Our results show that the interaction between the diamagnetic current and the radial component of the magnetic field increases the growth rate of the magnetorotational instability and generates a force perpendicular to the disc plane which may induce a torque. It is also shown that considering the radial component of the magnetic field and taking into account a radial gradient in the vertical component of the magnetic field causes an increase in the magnitudes of the growth rates of both the axisymmetric ($m=0$) and the non-axisymmetric ($m=1$) modes.
description: 9 pages, 5 figures, published in MNRAS, 2020, vol. 491, pages 5481-5488
An obstruction to asymptotic semistability and approximate critical metrics
Creators: name: Mabuchi, Toshiki
Publisher: name: arXiv
Year: 2004
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 32Q15(Primary), 32Q20, 14L24(Secondary)

description: In this paper, we consider an obstruction to asymptotic Chow-semistability of a polarized Kaehler algebraic manifold. Even when a linear algebraic group of positive dimension acts nontrivially and holomorphically on a polarized Kaehler algebraic manifold with constant scalar curvature, the vanishing of the obstruction allows us to generalize Donaldson's construction of approximate solutions for equations of balanced metrics.
description: to appear in Osaka J. Math. 41(2004)
The Relationship Between Third-Codon Position Nucleotide Content, Codon Bias, mRNA Secondary Structure and Gene Expression in the Drosophilid Alcohol Dehydrogenase Genes Adh and Adhr
Creators: name: Stephan, Wolfgang
name: Carlini, David
name: Chen, Ying
Publisher: name: Genetics Society of America
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Description to be added
Metabolism of Pelagic Cephalopods as a Function of Habitat Depth : A Reanalysis Using Phylogenetically Independent Contrasts
Creators: name: Carlini, David
name: Seibel, Brad A.
Publisher: name: Biol Bulletin
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Description to be added