cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessment of the inhibitory effect of two local plants on the emergence of four weeds and identification of their secondary metabolites: Case of Parkia biglobosa (Jacq.) R.Br.ex G.Don. and Tephrosia purpurea (L.) Pers.
Creators: name: Soumaïla Sourabié
name: Yacouba Sanou
name: Zerbo, Patrice
name: Soumaïla Sourabié
name: Yacouba Sanou
name: Zerbo, Patrice
Publisher: name: Unknown
Year: 2022
Subjects: subject: Crop Production/Industries
subject: Biological control
subject: Germination
subject: Inhibitory plants
subject: Organic compounds
subject: Weeds

description: In Burkina Faso, Senna occidentalis, Ipomoea eriocarpa, Pupalia lappacea and Triumfetta cordifolia are frequent weeds in the maize crop. This work evaluated the inhibitory effect of Parkia biglobosa pods and Tephrosia purpurea leaves and identifies their chemical compounds. Biological and chemical approaches were used to identify the weeds. The inhibitory effect of powders was evaluated on weed germination and growth. Experimental results showed that powders reduced both germination (p<0.001) and growth (p<0.016). Parkia biglobosa pods were rich in total flavonoids (544.2±1.4 µg mg-1) and condensed tannins (182.3±1.5 µg mg-1) than Tephrosia purpurea leaves which contained small amounts of total flavonoids (6.7±1.7 µg mg-1) and condensed tannins (5.7±1.2 µg mg-1). Parkia biglobosa pods could be used in the biological control of weeds.
Primary ciliary dyskinesia: Recent advances in diagnostics, genetics, and characterization of clinical disease
Creators: name: Davis, S.D.
name: Leigh, M.W.
name: Knowles, M.R.
name: Daniels, L.A.
name: Zariwala, M.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder of motile cilia that leads to oto-sino-pulmonary diseases and organ laterality defects in approximately 50% of cases. The estimated incidence of PCD is approximately 1 per 15,000 births, but the prevalence of PCD is difficult to determine, primarily because of limitations in diagnostic methods that focus on testing ciliary ultrastructure and function. Diagnostic capabilities have recently benefitted from (1) documentation of low nasal nitric oxide production in PCD and (2) discovery of biallelic mutations in multiple PCD-causing genes. The use of these complementary diagnostic approaches shows that at least 30% of patients with PCD have normal ciliary ultrastructure. More accurate identification of patients with PCD has also allowed definition of a strong clinical phenotype, which includes neonatal respiratory distress in >80% of cases, daily nasal congestion and wet cough starting soon after birth, and early development of recurrent/chronic middle-ear and sinus disease. Recent studies, using advanced imaging and pulmonary physiologic assessments, clearly demonstrate early onset of lung disease in PCD, with abnormal air flow mechanics by age 6-8 years that is similar to cystic fibrosis, and age-dependent onset of bronchiectasis. The treatment ofPCDis not standardized, and there are no validated PCD-specific therapies. Most patients with PCD receive suboptimal management, which should include airway clearance, regular surveillance of pulmonary function and respiratory microbiology, and use of antibiotics targeted to pathogens. The PCD Foundation is developing a network of clinical centers, which should improve diagnosis and management of PCD.
title: Ultrasonography of the Ankle: a step-by-step guide
Creators: name: Cruz, Manuel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Motility
subject: Education and training
subject: Athletic injuries
subject: Technical aspects
subject: Education
subject: Diagnostic procedure
subject: Ultrasound
subject: Musculoskeletal joint
subject: Extremities
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this article is to review the normal ultrasound anatomy of the ankle joint and propose a checklist-based evaluation protocol. Didactic illustrations and iconographic documentation are used for the scanning technique, probe positioning...
Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia
Creators: name: Krischer, J.
name: Qaqish, B.
name: Baker, B.R.
name: Brown, D.E.
name: Davis, S.D.
name: Hazucha, M.J.
name: Ferkol, T.W.
name: Knowles, M.R.
name: Olivier, K.N.
name: Zariwala, M.A.
name: Carson, J.L.
name: Lee, H.-S.
name: Leigh, M.W.
name: Atkinson, J.J.
name: Lavange, L.M.
name: Shapiro, A.J.
name: Horton, B.J.
name: Sagel, S.D.
name: Rosenfeld, M.
name: Milla, C.
name: Chawla, K.K.
name: Dell, S.D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Rationale: Several studies suggest that nasal nitric oxide (nNO) measurement could be a test for primary ciliary dyskinesia (PCD), but the procedure and interpretation have not been standardized. Objectives: Touse a standard protocol formeasuringnNOtoestablishadiseasespecific cutoff value at one site, and then validate at six other sites. Methods: At the lead site, nNO was prospectively measured in individuals later confirmed to have PCD by ciliary ultrastructural defects (n = 143) or DNAH11 mutations (n = 6); and in 78 healthy and 146 disease control subjects, including individuals with asthma (n = 37), cystic fibrosis (n = 77), and chronic obstructive pulmonary disease (n = 32). A disease-specific cutoff value was determined, using generalized estimating equations (GEEs). Six other sites prospectively measured nNO in 155 consecutive individuals enrolled for evaluation for possible PCD. Measurements and Main Results: At the lead site, nNO values in PCD (mean6standard deviation, 20.7624.1 nl/min; range, 1.5-207.3 nl/min) only rarely overlapped with the nNO values of healthy control subjects (304.6 6 118.8; 125.5-867.0 nl/min), asthma (267.8 6 103.2; 125.0-589.7 nl/min), or chronic obstructive pulmonary disease (223.7 6 87.1; 109.7-449.1 nl/min); however, therewas overlapwith cystic fibrosis (134.0673.5; 15.6-386.1 nl/min). The disease-specific nNOcutoff valuewas defined at 77 nl/minute (sensitivity, 0.98; specificity, .0.999). At six other sites, this cutoff identified 70 of the 71 (98.6%) participants with confirmed PCD. Conclusions: Using a standardized protocol in multicenter studies, nNO measurement accurately identifies individuals with PCD, and supports its usefulness as a test to support the clinical diagnosis of PCD.
title: CT evaluation of femoral rotational alignment in Total Knee arthroplasty (TKA): measured resection versus gap balancing technique
Creators: name: Manfredonia, Giorgia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal bone
subject: CT
subject: CT-High Resolution
subject: Statistics
subject: Comparative studies
subject: Motility

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To compare femoral component rotation in two groups of 50 patients with total knee arthroplasty using gap balanced (GB) vs measured resection (MR) surgical...
Effect of coordinate noncommutativity on the mass of a particle in a uniform field and the equivalence principle
Creators: name: Gnatenko, Kh. P.
name: Tkachuk, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the motion of a particle in a uniform field in noncommutative space which is rotationally invariant. On the basis of exact calculations it is shown that there is an effect of coordinate noncommutativity on the mass of a particle. A particular case of motion of a particle in a uniform gravitational field is considered and the equivalence principle is studied. We propose the way to solve the problem of violation of the equivalence principle in the rotationally invariant noncommutative space.
Among old materials and different approaches to enhance stability and electrochemical activity of Solid Oxide Cells
Creators: name: CLEMATIS, DAVIDE
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Perovskite materials are widely studied as cathode materials for intermediate-temperature solid oxide fuel cells (IT-SOFC) for their relevant properties regarding electrocatalytic activity or stability. Nevertheless, a material that combines both it is not yet available. Among them, La1-XSrxMnO3 (LSM), La1-xSrxCo1-yFeyO3 (LSCF), Ba1-xSrxCo1-yFeyO3 (BSCF), La1-xSrxFeO3 (LSF), La1-xBaxCoO3 (LBC), were deeply investigated but their properties are not completely exploited or optimized. In this PhD project all the reported electrode materials are investigated using different approaches. The study starts from LSM ? based electrodes, which show a change in kinetic mechanism under particular operating conditions. These results open new horizons about the employment of this material, up today considered not suitable for IT-SOFC temperature range. A first application, with promising results, is proposed here with a LSM infiltration in LSCF and BSCF scaffold. The presence of infiltrated-phase enhance stability and electrochemical activity of electrodes. Promising results are obtained also by mixing BSCF and LSCF powders. Three different BSCF:LSCF ratio are considered to produce three different cathodes. All the new compositions show an improvement of activity for oxygen reduction reaction, with very competitive values of polarization resistance. Moreover, one of these new electrodes has also a lowering of degradation rate compared with reference materials In the last year of this project, other two materials are combined and their interactions investigate. LSF, providing a high stability, is coupled with LBC, which has a really high surface electrocatalytic activity. The two materials are tested in different thin film systems. When they are mixed before the sintering stage react forming a new perovskite phase (Ba0.099Sr0.297La0.594Fe0.8Co0.2O3), with a higher activity. The reaction is avoided producing a bilayer system, and the presence of LBC top layer over a LSF dense thin film drastically reduces polarization resistance, highlighting promising results.
The emerging genetics of primary ciliary dyskinesia
Creators: name: Ferkol, T.W.
name: Zariwala, M.A.
name: Omran, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Primary ciliary dyskinesia (PCD) is an autosomal recessive, rare, genetically heterogeneous condition characterized by oto-sinopulmonary disease together with situs abnormalities (Kartagener syndrome) owing to abnormal ciliary structure and function. Most patients are currently diagnosed with PCD based on the presence of defective ciliary ultrastructure. However, diagnosis often remains challenging due to variability in the clinical phenotype and ciliary ultrastructural changes. Some patients with PCD have normal ciliary ultrastructure, which further confounds the diagnosis. A genetic test for PCD exists but is of limited value because it investigates only a limited number of mutations in only two genes. The genetics of PCD is complicated owing to the complexity of axonemal structure that is highly conserved through evolution, which is comprised of multiple proteins. Identifying a PCD-causing gene is challenging due to locus and allelic heterogeneity. Despite genetic heterogeneity, multiple tools have been used, and there are 11 known PCD-causing genes. All of these genes combined explain approximately 50% of PCD cases; hence, more genes need to be identified. This review briefly describes the current knowledge regarding the genetics of PCD and focuses on the methodologies used to identify novel PCD-causing genes, including a candidate gene approach using model organisms, next-generation massively parallel sequencing techniques, and the use of genetically isolated populations. In conclusion, we demonstrate the multipronged approach that is necessary to circumvent challenges due to genetic heterogeneity to uncover genetic causes of PCD.
Nanoscale resolution for fluorescence microscopy via adiabatic passage
Creators: name: Rubio, Juan Luis
name: Viscor, Daniel
name: Ahufinger, Verònica
name: Mompart, Jordi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Biological Physics (physics.bio-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We propose the use of the subwavelength localization via adiabatic passage technique for fluorescence microscopy with nanoscale resolution in the far field. This technique uses a Λ-type medium coherently coupled to two laser pulses: the pump, with a node in its spatial profile, and the Stokes. The population of the Λ system is adiabatically transferred from one ground state to the other except at the node position, yielding a narrow population peak. This coherent localization allows fluorescence imaging with nanometer lateral resolution. We derive an analytical expression to asses the resolution and perform a comparison with the coherent population trapping and the stimulated-emission-depletion techniques.
description: 5 pages, 3 figures
Ehrenfest breakdown of the mean-field dynamics of Bose gases
Creators: name: Han, Xizhi
name: Wu, Biao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The mean-field dynamics of a Bose gas is shown to break down at time $τ_h = (c_1/γ) \ln N$ where $γ$ is the Lyapunov exponent of the mean-field theory, $N$ is the number of bosons, and $c_1$ is a system-dependent constant. The breakdown time $τ_h$ is essentially the Ehrenfest time that characterizes the breakdown of the correspondence between classical and quantum dynamics. This breakdown can be well described by the quantum fidelity defined for reduced density matrices. Our results are obtained with the formalism in particle-number phase space and are illustrated with a triple-well model. The logarithmic quantum-classical correspondence time may be verified experimentally with Bose-Einstein condensates.
description: 6 pages, 4 figures
Menu recommendations : when do they work?
Creators: name: Catarci, Daniele
name: Laasner Vogt, Lea
name: Reijnen, Ester
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2023
Subjects: Recommendation
Food choice
Price
Position
150: Psychologie

description: Recommendations, such as “by the chef” help promote healthier and/or more sustainable food choices. However, little is known about whether recommendations are still effective when choices are few, as is typically the case in university cafés. Moreover, it is unclear how recommendations interact with factors such as price, etc. To address these questions, participants (N = 517) in a smartphone-based online study were visually presented with two menus (Dal or Curry) from which they had to choose one, with either none recommended or one of the two (none, Dal or Curry). Additionally, we manipulated the price of the menus (expensive or cheap) and the position of the menus (top or bottom). Participants were randomly assigned to one of the resulting 12 factor-level combinations (e.g., the recommended, more expensive Curry menu was on top). The subsequent analysis (probit model with ANOVA) with recommendation, price and position as independent variables and menu choice as dependent variable showed effects only with regard to the choice of the more popular menu, in this case the Curry (chosen by 66% of the participants). Specifically, when Curry was the expensive option, recommendation (regardless of position) negatively impacted choice (only 43% chose Curry), but not when Curry was the cheap option (87%).
A subsequent exploratory analysis shows that the different effects of recommendations can be attributed to the participants' interpretation of the recommendation (which was assessed at the end of the respective study). Specifically, when the cheap Curry menu was recommended, participants were more likely to perceive the recommendation as a well-intentioned nudge toward a healthier or more sustainable choice. In contrast, when the Curry menu was the expensive option, participants were more likely to interpret the recommendation as a marketing strategy to increase sales. In summary, recommendations can influence menu choice in an online environment, but their effectiveness depends on pre-existing preferences for the recommended menu and is further moderated by the price of the menu.
2D or not 2D: the effect of dimensionality on the dynamics of fingering convection at low Prandtl number
Creators: name: Garaud, Pascale
name: Brummell, Nicholas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Fingering convection (otherwise known as thermohaline convection) is an instability that occurs in stellar radiative interiors in the presence of unstable compositional gradients. Numerical simulations have been used in order to estimate the efficiency of mixing induced by this instability. However, fully three-dimensional (3D) computations in the parameter regime appropriate for stellar astrophysics (i.e. low Prandtl number) are prohibitively expensive. This raises the question of whether two-dimensional (2D) simulations could be used instead to achieve the same goals. In this work, we address this issue by comparing the outcome of 2D and 3D simulations of fingering convection at low Prandtl number. We find that 2D simulations are never appropriate. However, we also find that the required 3D computational domain does not have to be very wide: the third dimension need only contain a minimum of two wavelengths of the fastest-growing linearly unstable mode to capture the essentially 3D dynamics of small-scale fingering. Narrow domains, however, should still be used with caution since they could limit the subsequent development of any large-scale dynamics typically associated with fingering convection.
description: Submitted to ApJ
title: An Effective Alternative Management Way for Massive Pulmonary Embolism: Percutaneous Catheter-Directed Interventions
Creators: name: Kırlı, Serap
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Embolism / Thrombosis
subject: Treatment effects
subject: Recanalisation
subject: CT-Angiography
subject: Catheter arteriography
subject: Pulmonary vessels

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The goal of this exhibit is to: Discuss the pathophysiology and clinical features of acute pulmonary embolism (PE), Discuss the importance of Computed Tomographic (CT) pulmonary angiography which is becoming the standard of care at many centers for...
(101566) Martha Phillips
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity
Creators: name: Drumm, M.L.
name: Fan, H.
name: Zariwala, M.A.
name: Weston, B.W.
name: Burch, L.H.
name: Taylor-Cousar, J.L.
name: Calloway, H.
name: Wright, F.A.
name: Knowles, M.R.
name: Pace, R.G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Background: The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a subset of patients with CF. Methods and Principal Findings: Clinical information and DNA was collected on >800 patients with the ΔF508/ΔF508 genotype. Patients in the most severe and mildest quartiles for lung phenotype were enrolled. Blood samples underwent lymphocyte transformation and DNA extraction using standard methods. PCR and sequencing were performed using standard techniques to identify the 9 SNPs required to determine ABO blood type, and to identify the four SNPs that account for 90-95% of Lewis status in Caucasians. Allele identification of the one nonsynonymous SNP in FUT2 that accounts for >95% of the incidence of nonsecretor phenotype in Caucasians was completed using an ABI Taqman assay. The overall prevalence of ABO types, and of FUT2 (secretor) and FUT 3 (Lewis) alleles was consistent with that found in the Caucasian population. There was no difference in distribution of ABH type in the severe versus mild patients, or the age of onset of Pseudomonas aeruginosa infection in the severe or mild groups. Multivariate analyses of other clinical phenotypes, including gender, asthma, and meconium ileus demonstrated no differences between groups based on ABH type. Conclusions and Significance: Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the ΔF508 mutation.
Mutations of DNAI1 in primary ciliary dyskinesia: Evidence of founder effect in a common mutation
Creators: name: Pennarun, G.
name: Morgan, L.C.
name: Chung, E.M.K.
name: Duriez, B.
name: Olbrich, H.
name: Amselem, S.
name: Rutland, J.
name: Mitchison, H.M.
name: Zariwala, M.A.
name: Loges, N.T.
name: Carson, J.L.
name: Leigh, M.W.
name: De Iongh, R.U.
name: Chodhari, R.
name: Noone, P.G.
name: Omran, H.
name: Kennedy, M.P.
name: Pradal, U.
name: Knowles, M.R.
name: Lori, A.
name: Escudier, E.
name: Bridoux, A.-M.
name: Ceppa, F.
name: Horvath, J.
name: Hazucha, M.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Rationale: Primary ciliary dyskinesia (PCD) is a rare, usually autosomal recessive, genetic disorder characterized by ciliary dysfunction, sino-pulmonary disease, and situs inversus. Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia. Objectives: We analyzed DNAI1 to identify disease-causing mutations in PCD and to determine if the previously reported IVS1+2_3insT (219+3insT) mutation represents a "founder" or "hot spot" mutation. Methods: Patients with PCD from 179 unrelated families were studied. Exclusion mapping showed no linkage to DNAI1 for 13 families; the entire coding region was sequenced in a patient from the remaining 166 families. Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed on nasal epithelial RNA in 14 families. Results: Mutations in DNAI1 including 12 novel mutations were identified in 16 of 179 (9%) families; 14 harbored biallelic mutations. Deep intronic splice mutations were not identified by reverse transcriptase-polymerase chain reaction. The prevalence of mutations in families with defined ODA defect was 13%; no mutations were found in patients without a defined ODA defect. The previously reported IVS1+2_3insT mutation accounted for 57% (17/30) of mutant alleles, and marker analysis indicates a common founder for this mutation. Seven mutations occurred in three exons (13, 16, and 17); taken together with previous reports, these three exons are emerging asmutation clusters harboring29%(12/42) of mutant alleles. Conclusions: A total of 10% of patients with PCD are estimated to harbor mutations in DNAI1; most occur as a common founder IVS1+2_3insT or in exons 13, 16, and 17. This information is useful for establishing a clinical molecular genetic test for PCD.
title: Role of virtopsy in the interpretation of gas presence in fatal diving accidents
Creators: name: Giaconi, Claudia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Embolism / Thrombosis
subject: Medico-legal issues
subject: CT
subject: Forensic / Necropsy studies

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: According to the Annual Diving Report (DAN) and the Sports and Fitness Industry Association, diving fatalities in 2014 were around 2 out of every 100,000 recreational divers in the US. This number seems to be stationary despite improvements in...
DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects
Creators: name: Blouin, J.-L.
name: Knowles, M.R.
name: Ahrens, P.
name: Olbrich, H.
name: Kuhl, H.
name: Loges, N.T.
name: Nüsslein, T.
name: Antonarakis, S.E.
name: Fliegauf, M.
name: Noone, P.G.
name: Sudbrak, R.
name: Bartoloni, L.
name: Reinhardt, R.
name: Kennedy, M.
name: Hornef, N.
name: Wildhaber, J.
name: Horvath, J.
name: Griese, M.
name: Zariwala, M.A.
name: Omran, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections and randomization of left-right body asymmetry. To date, autosomal recessive mutations have only been identified in a small number of patients involving DNAI1 and DNAH5, which encode outer dynein arm components. Methods: We screened 109 white PCD families originating from Europe and North America for presence of DNAH5 mutations by haplotype analyses and/or sequencing. Results: Haplotype analyses excluded linkage in 26 families. In 30 PCD families, we identified 33 novel (12 nonsense, 8 frameshift, 5 splicing, and 8 missense mutations) and two known DNAH5 mutations. Weobserved clustering of mutationswithin five exons harboring 27 mutant alleles (52%) of the 52 detected mutant alleles. Interestingly, 6 (32%) of 19 PCD families with DNAH5 mutations from North America carry the novel founder mutation 10815delT. Electron microscopic analyses in 22 patients with PCD with mutations invariably detected outer dynein arm ciliary defects. High-resolution immunofluorescence imaging of respiratory epithelial cells from eight patients with DNAH5 mutations showed mislocalization of mutant DNAH5 and accumulation at the microtubule organizing centers. Mutant DNAH5 was absent throughout the ciliary axoneme in seven patients and remained detectable in the proximal ciliary axoneme in one patient carrying compound heterozygous splicing mutations at the 3′-end (IVS75-2A>T, IVS76+5G>A). In a preselected subpopulation with documented outer dynein arm defects (n = 47), DNAH5 mutations were identified in 53% of patients. Conclusions: DNAH5 is frequently mutated in patients with PCD exhibiting outer dynein arm defects and mutations cluster in five exons.
Analysis of the attainable efficiency of a direct-bandgap betavoltaic element
Creators: name: Sachenko, A. V.
name: Shkrebtii, A. I.
name: Korkishko, R. M.
name: Kostylyov, V. P.
name: Kulish, N. P.
name: Sokolovskiy, I. O.
name: Evstigneev, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Conversion of energy of beta-particles into electric energy in a p-n junction based on direct-bandgap semiconductors, such as GaAs, considering realistic semiconductor system parameters is analyzed. An expression for the collection coefficient, $Q$, of the electron-hole pairs generated by beta-electrons is derived taking into account the existence of the dead layer. We show that the collection coefficient of beta-electrons emitted by a \Tr-source to a GaAs p-n junction is close to 1 in a broad range of electron lifetimes in the junction, ranging from $10^{-9}$ to $10^{-7}$ s. For the combination \Pm/GaAs, $Q$ is relatively large ($\ge 0.4$) only for quite long lifetimes (about $10^{-7}$ s) and large thicknesses (about $100\,μ$m) of GaAs p-n junctions. For realistic lifetimes of minority carriers and their diffusion coefficients, the open-circuit voltage realized due to the irradiation of a GaAs p-n junction by beta-particles is obtained. The attainable beta-conversion efficiency $η$ in the case of a \Tr/GaAs combination is found to exceed that of the \Pm/GaAs combination.
$HZγ$ production at $14~{\rm TeV}$ LHC in next-to-leading order QCD
Creators: name: Shou-Jian, Xiong
name: Wen-Gan, Ma
name: Lei, Guo
name: Ren-You, Zhang
name: Chong, Chen
name: Mao, Song
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the process $pp \rightarrow HZγ+ X$ at the $\sqrt{s}=14~{\rm TeV}$ LHC up to the QCD next-to-leading order (NLO), and discuss the kinematic distributions of final products after on-shell Higgs and $Z$-boson decays by adopting the narrow width approximation. The dependence of the leading order (LO) and the QCD NLO corrected integrated cross sections on the factorization/renormalization scale is studied. Our results show that the LO integrated cross section and kinematic distributions are significantly enhanced by the NLO QCD corrections, and the NLO QCD $K$-factor strongly depends on the observables and phase space. We conclude that in precision experimental data analyse for probing the $HZγ$ coupling we should consider the NLO QCD corrections and put proper constraints on lepton-pair invariant mass to reduce the background.
description: 16pages, 7 figures
Effect of harvesting stage and storage condition on post-harvest quality and sensory acceptability of mango fruit in Gamo Zone, Southern Ethiopia
Creators: name: Wasihun Wale Eyese
name: Ermias Dureto Badebo
name: Melese Lema Tessema
name: Wasihun Wale Eyese
name: Ermias Dureto Badebo
name: Melese Lema Tessema
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agricultural and Food Policy
subject: Harvesting stage
subject: Mango fruit
subject: Post-harvest quality
subject: Sensory acceptability
subject: Storage conditions

description: The effect of harvesting stages (mature green, half-ripe and full ripe) and storage conditions (zero energy cool chamber, wooden box and underground storage) on post-harvest quality and sensory acceptability of mango fruit was evaluated. Three harvesting stages of mango fruit were harvested and 10 kg of mango fruit was stored in three storage conditions until the end of the storage period. Spoilage and weight loss of mango fruit were recorded from storage in three-day intervals. All samples were analyzed for Post-harvest quality of mango fruit before and after storage at Arba Minch University, Abaya Campus Chemistry laboratory, and sensory acceptability was evaluated by using untrained 45 panelists at the end of the storage period. Completely Randomized Design in factorial arrangement with three replications was used to evaluate the shelf life and postharvest quality of mango fruit. Weight loss, spoilage, firmness and total soluble solids of mango fruit were increased while vitamin C, moisture content and titratable acidity were decreased with increased storage time. The vitamin C content of mango fruit was highest at half ripe in a zero energy cool chamber and was lowest at full ripe harvested in a wooden box after the end of the storage period. The highest overall acceptability of mango fruit was observed at the half-ripe harvested stage in zero energy cool chambers while the lowest was observed at the mature green harvested stage mango fruit in a wooden box after the end of the storage period. Based on the current study, half ripen mango fruit in zero energy cool chamber storage recorded the least percent of weight loss, spoilage amount, maximum shelf life and quality, especially vitamin C content and higher overall acceptability. Further study will be needed on the microbial quality of mango fruit in different harvesting stages and storage conditions during storage periods.
(101568) Edward Phillips
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CRACK TROOPS OR BLOODY KILLERS? STATES, POLITICAL PARTIES, AND MERCENARIES 1805-2017
Creators: name: CASIRAGHI, MATTEO CESARE MARIO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Addressing political attitudes toward mercenaries and contractors, this dissertation offers an original empirical contribution and a new theoretical framework to investigate international norms, and relations between political parties and private armed groups. I code and analyze all references to mercenaries and private military companies in the Italian and British Parliamentary debates from 1805 to 2017. Regarding the norm, I demonstrate that the anti-mercenary norm evolves through three critical moments. Between 1805 and 1945, an anti-mercenary moral norm is present to a relevant extent in politicians? debates, though it does not consistently constrain states? behavior. The norm is weak. Between 1945 and 1991, anti-mercenary sentiments start to decline, and all discussions about their operations are clearly distorted by Cold War dynamics. The norm is very weak and highly politicized. After 1991, the norm targets security contractors for a brief period, as negative references and moral attacks significantly decrease. The norm disappears. Concerning instead political parties? attitudes toward mercenaries and contractors, I demonstrate that from 1945 to 1991 Cold War dynamics trump any other moral or functional consideration on mercenaries. In Italy, leftist parties are almost exclusively responsible for the aversion toward hired soldiers. Anti-Americanism, anti-colonialism, and fear of coups, emerge as the main drivers of political hostility. Conversely, British parties? attitudes converge on a similar aversion, though the reasons behind the antagonism differ. While anti-communism dominates the Conservatives? discourses, the Labour presents a more colorful picture, with Cold War-related antagonism emerging from the extreme left. Conversely, after 1991 the political and economic problems of privatization become protagonists in both countries, as Italian parties converge on comparable postures, whereas a more significant gap emerges in the United Kingdom. The results of this work produce insightful empirical and theoretical implications for the literature on mercenaries and contractors, on political parties and Foreign Policy, on the Cold War, and on international norms.
Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia
Creators: name: Omran, H.
name: Zariwala, M.A.
name: Knowles, M.R.
name: Kennedy, M.
name: Wildhaber, J.H.
name: Fliegauf, M.
name: Olbrich, H.
name: Horvath, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Rationale: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by recurrent infections of the airways and situs inversus in half of the affected offspring. The most frequent genetic defects comprise recessive mutations of DNAH5 and DNAI1, which encode outer dynein arm (ODA) components. Diagnosis of PCD usually relies on electron microscopy, which is technically demanding and sometimes difficult to interpret. Methods: Using specific antibodies, we determined the subcellular localization of the ODA heavy chains DNAH5 and DNAH9 in human respiratory epithelial and sperm cells of patients with PCD and control subjects by high-resolution immunofluorescence imaging. We also assessed cilia and sperm tail function by high-speed video microscopy. Results: In normal ciliated airway epithelium, DNAH5 and DNAH9 show a specific regional distribution along the ciliary axoneme, indicating the existence of at least two distinct ODA types. DNAH5 was completely or only distally absent from the respiratory ciliary axoneme in patients with PCD with DNAH5- (n = 3) or DNAI1- (n = 1) mutations, respectively, and instead accumulated at the microtubule-organizing centers. In contrast to respiratory cilia, sperm tails from a patient with DNAH5 mutations had normal ODA heavy chain distribution, suggesting different modes of ODA generation in these cell types. Blinded investigation of a large cohort of patients with PCD and control subjects identified DNAH5 mislocalization in all patients diagnosed with ODA defects by electron microscopy (n = 16). Cilia with complete axonemal DNAH5 deficiency were immotile, whereas cilia with distal DNAH5 deficiency showed residual motility. Conclusions: Immunofluorescence staining can detect ODA defects, which will possibly aid PCD diagnosis.
title: Deep Learning for automatically analyzing diffusion-weighted images of Nasopharyngeal cancer
Creators: name: Mader, Kevin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Cancer
subject: Computer Applications-Virtual imaging
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-3D
subject: Neural networks
subject: MR-Diffusion/Perfusion
subject: CAD
subject: MR physics
subject: Head and neck
subject: Computer applications

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Nasopharyngeal Cancer (NPC) is particularly prevalent in southeast Asia. The correct staging and grading of the tumor is of pivotal importance and guides treatment. These tasks, that strongly rely on modern imaging techniques such as MRI, CT and PET...
Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients
Creators: name: King, S.M.
name: Omran, H.
name: Olbrich, H.
name: Fliegauf, M.
name: Neesen, J.
name: Fekete, G.
name: Knowles, M.R.
name: Zariwala, M.A.
name: Reinhardt, R.
name: Mitchison, H.
name: Kispert, A.
name: Horváth, J.
name: Sudbrak, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by chronic infections of the upper and lower airways, randomization of left/right body asymmetry, and reduced fertility. The phenotype results from dysfunction of motile cilia of the respiratory epithelium, at the embryonic node and of sperm flagella. Ultrastructural defects often involve outer dynein arms (ODAs), that are composed of several light (LCs), intermediate, and heavy (HCs) dynein chains. We recently showed that recessive mutations of DNAH5, the human ortholog of the biflagellate Chlamydomonas ODA γ-HC, cause PCD. In Chlamydomonas, motor protein activity of the γ-ODA-HC is regulated by binding of the axonemal LC1. We report the identification of the human (DNAL1) and murine (Dnal1) orthologs of the Chlamydomonas LC1-gene. Northern blot and in situ hybridization analyses revealed specific expression in testis, embryonic node, respiratory epithelium, and ependyma, resembling the DNAH5 expression pattern. In silico protein analysis showed complete conservation of the LC1/γ-HC binding motif in DNAL1. Protein interaction studies demonstrated binding of DNAL1 and DNAH5. Based on these findings, we considered DNAL1 a candidate for PCD and sequenced all exons of DNAL1 in 86 patients. Mutational analysis was negative, excluding a major role of DNAL1 in the pathogenesis of PCD.
LA FORMAZIONE DEGLI INSEGNANTI IN ITALIA. LA VALUTAZIONE DI DUE POLITICHE DI FORMAZIONE PROFESSIONALE PER INSEGNANTI DI SCUOLA MEDIA
Creators: name: ABBIATI, GIOVANNI MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: This dissertation aims at providing empirical evidence on the effectiveness of two training programs for math teachers in southern Italy (M@t.abel+ and PQM). The programs are structured as content focused, one year lenght blended training sessions. Exploiting similarities and differences in the training (mainly, on organization of tutoring sessions and the presence on incentives), the analysis show positive effects of the training on both students outcomes and teacher short and medium term behaviours. Implications for policy are discussed.
(101570) Samuel Phillips
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Research on the redshift evolution of luminosity function and selection effect of GRBs
Creators: name: Tan, W. W.
name: Wang, F. Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the redshift evolution of the luminosity function (LF) and redshift selection effect of long gamma-ray bursts (LGRBs). The method is to fit the observed peak flux and redshift distributions, simultaneously. To account for the complex triggering algorithm of Swift, we use a flux triggering efficiency function. We find evidence supporting an evolving LF, where the break luminosity scales as $L_b\propto (1+z)^τ$, with $τ=3.5^{+0.4}_{-0.2}$ and $τ=0.8^{+0.1}_{-0.08}$ for two kind of LGRB rate models. The corresponding local GRB rates are $\dot{R}(0)=0.86^{+0.11}_{-0.08} \yr^{-1}\Gpc^{-3}$ and $\dot{R}(0)= 0.54^{+0.25}_{-0.07} \yr^{-1}\Gpc^{-3}$, respectively. Furthermore, by comparing the redshift distribution between the observed one and our mocked one, we find that the redshift detection efficiency of the flux triggered GRBs decreases with redshift. Especially, a great number of GRBs miss their redshifts in the redshift range of $1
description: 8 pages, 4 figures, 1 table, accepted by MNRAS
JAMESfocus : Handyverhalten und Nachhaltigkeit - aktuelle Trends
JAMESfocus : Utilisation du portable et durabilité - les tendances actuelles
JAMESfocus : cellulare, comportamenti e sostenibilità - trendi attuali
Creators: name: Külling-Knecht, Céline
name: Waller, Gregor
name: Bernath, Jael
name: Willemse, Isabel
name: Suter, Lilian
name: Eggli, Tim
name: Süss, Daniel
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2023
Subjects: Medien
Psychologie
Mediennutzung
Nachhaltigkeit
Medienkompetenz
Jugendliche
JAMES Studie
302.23: Medien
305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)

description: Bericht verfügbar in Deutsch, Französisch und Italienisch
description: Der Bericht widmet sich dem Thema Handyverhalten und Nachhaltigkeit: Im Fokus stehen verschiedene Fragen rund um das Thema der nachhaltigen Handy- bzw. Smartphonenutzung: Wie hoch ist der Anteil der Jugendlichen, die gebrauchte Geräte verwenden? Welche Aspekte eines Smartphones – wie Marke, Design, Qualität, Reparierbarkeit oder Langlebigkeit – sind für die jungen Nutzenden besonders wichtig? Was für Erfahrungen haben Jugendliche mit der Reparatur ihrer Geräte bereits gemacht? Und wie lange verwenden Jugendliche ihr Smartphone im Durchschnitt? Zusätzlich werden Vergleiche angestellt, um zu ermitteln, ob sich die Haltung der Jugendlichen gegenüber Fragen der Nachhaltigkeit seit der letzten Umfrage dazu im Jahr 2016 verändert hat.
Genetic modifiers of lung disease in cystic fibrosis
Creators: name: Konstan, M.W.
name: Pace, R.
name: Corey, M.
name: Schluchter, M.D.
name: Dorfman, R.
name:  Zariwala, M.
name: Knowles, M.R.
name: Dunn, J.M.
name: Yankaskas, J.R.
name:  Sandford, A.J.
name: Wright, F.A.
name: Zielenski, J.
name: Xu, A.
name: Durie, P.
name: Fargo, D.
name: Zou, F.
name: Drumm, M.L.
name: Goddard, K.
name: Handler, A.
name: Darrah, R.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: BACKGROUND: Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis. METHODS: We performed two studies with different patient samples. We first tested 808 patients who were homozygous for the ΔF508 mutation and were classified as having either severe or mild lung disease, as defined by the lowest or highest quartile of forced expiratory volume in one second (FEV 1), respectively, for age. We genotyped 16 polymorphisms in 10 genes reported by others as modifiers of disease severity in cystic fibrosis and tested for an association in patients with severe disease (263 patients) or mild disease (545). In the replication (second) study, we tested 498 patients, with various CFTR genotypes and a range of FEV 1 values, for an association of the TGFβ1 codon 10 CC genotype with low FEV 1. RESULTS: In the initial study, significant allelic and genotypic associations with phenotype were seen only for TGFβ1 (the gene encoding transforming growth factor β1), particularly the -509 and codon 10 polymorphisms (with P values obtained with the use of Fisher's exact test and logistic regression ranging from 0.006 to 0.0002). The odds ratio was about 2.2 for the highest-risk TGFβ1 genotype (codon 10 CC) in association with the phenotype for severe lung disease. The replication study confirmed the association of the TGFβ1 codon 10 CC genotype with more severe lung disease in comparisons with the use of dichotomized FEV 1 for severity status (P=0.0002) and FEV 1 values directly (P=0.02). CONCLUSIONS: Genetic variation in the 5′ end of TGFβ1 or a nearby upstream region modifies disease severity in cystic fibrosis.