cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of The influence of weather on the population dynamics of common mosquito vector species in the Canadian Prairies
Creators: name: Baril, Cole
name: Pilling, Ben G.
name: Mikkelsen, Milah J.
name: Sparrow, Jessica M.
name: Duncan, Carlyn A. M.
name: Koloski, Cody W.
name: LaZerte, Stefanie E.
name: Cassone, Bryan J.
Publisher: name: figshare
Year: 2023
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Location, coordinates, regional or rural municipality, and population size for each Western (A) and Central/Eastern (B) Manitoba mosquito trapping location.
Additional file 2 of Describing the burden of moderate exacerbations in patients with asthma from the Extended Salford Lung Study (Ext-SLS): a retrospective cohort study
Creators: name: Goodall, Emma
name: Rothnie, Kieran J.
name: Numbere, Beade
name: Zhang, Shiyuan
name: Compton, Chris
name: Wood, Robert
name: Tritton, Theo
name: Wild, Rosie
name: Small, Mark
name: Vestbo, Jørgen
name: Woodcock, Ashley
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2: Figure S2 Patient attrition
BTLA Expression and Function Are Impaired on SLE B Cells
Creators: name: Wiedemann, Annika
name: Lettau, Marie
name: Weißenberg, Sarah Y.
name: Stefanski, Ana-Luisa
name: Schrezenmeier, Eva-Vanessa
name: Rincon-Arevalo, Hector
name: Reiter, Karin
name: Alexander, Tobias
name: Hiepe, Falk
name: Lino, Andreia C.
name: Dörner, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: BTLA/CD272
subject: SLE
subject: B cells
subject: SYK
subject: plasmacytosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: B- and T-lymphocyte attenuator (BTLA/CD272) is an inhibitory checkpoint molecule expressed on T and B cells. Prior studies reported defective function of BTLA by T cells in patients with systemic lupus erythematosus (SLE), whereas nothing is known about its role on B cells in SLE, a disease with various B cell abnormalities. Peripheral blood mononuclear cells (PBMCs) from 23 healthy donors (HD) and 34 SLE patients were stained for BTLA and its expression on B cells was assessed. PBMCs or CD27(-)IgD(+) naive B cells were stimulated together with an activating anti-BTLA antibody or an inhibitor of spleen tyrosine kinase (SYK) and differentiation as well as the expression of activation markers CD71, PD-1 and CD86 were analyzed. Our phenotypic and functional studies revealed reduced BTLA expression on CD27(-)IgD(+) naive B cells from SLE patients (p=0.0017) related to anti-dsDNA antibody titers (p=0.0394) and SIGLEC-1/CD169 expression on monocytes (p=0.0196), a type I interferon marker related to disease activity. BTLA engagement was found to control CpG/TLR9 activation limiting plasmablast (p=0.0156) and B cell memory induction (p=0.0078) in normal B cells in contrast to other B cell activation pathways (CD40, BCR). These BTLA functions were impaired in SLE B cells. Inhibition of SYK was found to mimic the effects of BTLA activity in vitro. Thus, is it possible that reduced BTLA expression and function of CD27-IgD+ antigen- and T cell-inexperienced SLE B cells could be overcome by SYK inhibition which should be tested in future studies as potential therapeutic principle.
Confusing the extragalactic neutrino flux limit with a neutrino propagation limit
Creators: name: Barranco, J.
name: Miranda, O. G.
name: Moura, C. A.
name: Rashba, T. I.
name: Rossi-Torres, F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the possible suppression of the extragalactic neutrino flux due to a nonstandard interaction during its propagation. In particular, we study neutrino interaction with an ultra-light scalar field dark matter. It is shown that the extragalactic neutrino flux may be suppressed by such an interaction, leading to a new mechanism to reduce the ultra-high energy neutrino flux. We study both the cases of non-self-conjugate as well as self-conjugate dark matter. In the first case, the suppression is independent of the neutrino and dark matter masses. We conclude that care must be taken when explaining limits on the neutrino flux through source acceleration mechanisms only, since there could be other mechanisms for the reduction of the neutrino flux.
description: 15 pages, 4 figures. Important changes implemented. Abstract modified. Conclusions remain. To be published in JCAP
Additional file 3 of Describing the burden of moderate exacerbations in patients with asthma from the Extended Salford Lung Study (Ext-SLS): a retrospective cohort study
Creators: name: Goodall, Emma
name: Rothnie, Kieran J.
name: Numbere, Beade
name: Zhang, Shiyuan
name: Compton, Chris
name: Wood, Robert
name: Tritton, Theo
name: Wild, Rosie
name: Small, Mark
name: Vestbo, Jørgen
name: Woodcock, Ashley
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 3: Figure S3 Sensitivity analyses of self-reported moderate asthma exacerbations (pre-index), by maintenance treatment class at index
Additional file 2 of The influence of weather on the population dynamics of common mosquito vector species in the Canadian Prairies
Creators: name: Baril, Cole
name: Pilling, Ben G.
name: Mikkelsen, Milah J.
name: Sparrow, Jessica M.
name: Duncan, Carlyn A. M.
name: Koloski, Cody W.
name: LaZerte, Stefanie E.
name: Cassone, Bryan J.
Publisher: name: figshare
Year: 2023
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2. Trapping locations for each city/town in 2020 and 2021.
Arrangements stable under the Coxeter groups
Creators: name: Kamiya, Hidehiko
name: Takemura, Akimichi
name: Terao, Hiroaki
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 20F55, 32S22, 52C35

description: Let B be a real hyperplane arrangement which is stable under the action of a Coxeter group W. Then B acts naturally on the set of chambers of B. We assume that B is disjoint from the Coxeter arrangement A=A(W) of W. In this paper, we show that the W-orbits of the set of chambers of B are in one-to-one correspondence with the chambers of C=A\cup B which are contained in an arbitrarily fixed chamber of A. From this fact, we find that the number of W-orbits of the set of chambers of B is given by the number of chambers of C divided by the order of W. We will also study the set of chambers of C which are contained in a chamber b of B. We prove that the cardinality of this set is equal to the order of the isotropy subgroup W_b of b. We illustrate these results with some examples, and solve an open problem in Kamiya, Takemura and Terao [Ranking patterns of unfolding models of codimension one, Adv. in Appl. Math. (2010)] by using our results.
Coherent and incoherent dynamics in excitonic energy transfer: correlated fluctuations and off-resonance effects
Creators: name: McCutcheon, Dara P. S.
name: Nazir, Ahsan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the nature of the energy transfer process within a pair of coupled two-level systems (donor and acceptor) subject to interactions with the surrounding environment. Going beyond a standard weak-coupling approach, we derive a master equation within the polaron representation that allows for investigation of both weak and strong system-bath couplings, as well as reliable interpolation between these two limits. With this theory, we are then able to explore both coherent and incoherent regimes of energy transfer within the donor-acceptor pair. We elucidate how the degree of correlation in the donor and acceptor fluctuations, the donor-acceptor energy mismatch, and the range of the environment frequency distribution impact upon the energy transfer dynamics. In the resonant case (no energy mismatch) we describe in detail how a crossover from coherent to incoherent transfer dynamics occurs with increasing temperature [A. Nazir, Phys. Rev. Lett. 103, 146404 (2009)], and we also explore how fluctuation correlations are able to protect coherence in the energy transfer process. We show that a strict crossover criterion is harder to define when off-resonance, though we find qualitatively similar population dynamics to the resonant case with increasing temperature, while the amplitude of coherent population oscillations also becomes suppressed with growing site energy mismatch.
description: 14 pages, 7 figures, builds upon PRL 103, 146404 (2009) (arXiv:0906.0592). Comments welcome. V2 - Section IV shortened to improve presentation, references updated, new Imperial College affiliation added for A. Nazir. Published version
Oscillating instanton solutions in curved space
Creators: name: Lee, Bum-Hoon
name: Lee, Chul H.
name: Lee, Wonwoo
name: Oh, Changheon
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate oscillating instanton solutions of a self-gravitating scalar field between degenerate vacua. We show that there exist O(4)-symmetric oscillating solutions in a de Sitter background. The geometry of this solution is finite and preserves the $Z_{2}$ symmetry. The nontrivial solution corresponding to tunneling is possible only if the effect of gravity is taken into account. We present numerical solutions of this instanton, including the phase diagram of solutions in terms of the parameters of the present work and the variation of energy densities. Our solutions can be interpreted as solutions describing an instanton-induced domain wall or braneworld-like object rather than a kink-induced domain wall or braneworld. The oscillating instanton solutions have a thick wall and the solutions can be interpreted as a mechanism providing nucleation of the thick wall for topological inflation. We remark that $Z_{2}$ invariant solutions also exist in a flat and anti-de Sitter background, though the physical significance is not clear.
description: 25 pages, 11 figues. Some typos corrected, references added, and Ch3. modified according to referee's comments
Stress-Induced Enhanced Long-Term Potentiation and Reduced Threshold for N-Methyl-D-Aspartate Receptor- and β-Adrenergic Receptor-Mediated Synaptic Plasticity in Rodent Ventral Subiculum
Creators: name: Bartsch, Julia C.
name: Cramon, Monique Von
name: Gruber, David
name: Heinemann, Uwe
name: Behr, Joachim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: subiculum
subject: long-term potentiation
subject: stress
subject: norepinephrine
subject: metaplasticity
subject: β-adrenergic receptor
subject: hippocampus
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Stress is a biologically relevant signal and can modulate hippocampal synaptic plasticity. The subiculum is the major output station of the hippocampus and serves as a critical hub in the stress response network. However, stress-associated synaptic plasticity in the ventral subiculum has not been adequately addressed. Therefore, we investigated the impact of a single exposure to an inherently stressful two-way active avoidance conditioning on the induction of long-term potentiation (LTP) at CA1-subiculum synapses in ventral hippocampal slices from young adult rats 1 day after stressor exposure. We found that acute stress enhanced LTP and lowered the induction threshold for a late-onset LTP at excitatory CA1 to subicular burst-spiking neuron synapses. This late-onset LTP was dependent on the activation of beta-adrenergic and glutamatergic N-methyl-D-aspartate receptors and independent of D1/D5 dopamine receptor activation. Thereby, we present a cellular mechanism that might contribute to behavioral stress adaptation after acute stressor exposure.
Humor and Fear—Two Sides of the Same Coin?: Experimental Evidence on Humor Appeals in Health Communication Related to Childhood Vaccination
Creators: name: Fischer, Florian
name: Carow, Franziska
name: Gillitzer, Stefanie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: humor
subject: health
subject: communication
subject: science
subject: herd immunity
subject: vaccine
subject: emotion
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Until now, health communication has largely failed to debunk fears and caveats related to vaccination. This study aims to investigate the effects of different text types used in health communication in an experimental study design. A neutrally formulated text was compared to a humorous text using the formula of a fairytale. Overall, the study indicates no additional value in using the humorous format as an innovative and target-group-oriented approach to inform readers about scientific evidence related to vaccination. Although the effects of the two text types do not differ, the credibility of the neutrally formulated text was much more likely to be judged as high. This indicates that the perception of credibility is not the only criterion in health communication leading to knowledge gains and changes in health-related attitudes and behaviors.
What Judges Want to Know From Forensic Evaluators in Child Custody and Child Protection Cases: Analyzing Forensic Assignments With Latent Dirichlet Allocation
Creators: name: Zumbach, Jelena
name: Volbert, Renate
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: forensic evaluation
subject: referral legal question
subject: child custody
subject: child endangerment
subject: latent Dirichlet allocation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: This study analyzes the questions on aspects of child custody, visitation rights, or child endangerment that judges pose to forensic psychologists in family law proceedings. Before conducting a psychological evaluation, the legal question in the referral has to be translated into case-specific, forensically relevant issues. The only overarching principle guiding this process is the "best interests of the child" criterion. Literature indicates that judges often struggle to define what variables should be specified for a psychological evaluation in their referral questions. This study aims to contribute to a better understanding of the information judges would like to ascertain from psychological evaluators in child custody and child protection proceedings-an understanding allowing a clearer determination of whether forensic psychologists as experts can deliver this information. Latent Dirichlet allocation (LDA) is used to analyze the referral questions that these judges pose to forensic evaluators in terms of (a) underlying topics (latent dimensions) that can be identified within the referral questions and (b) the probability distributions of legal terms and forensic issues contained in the referral questions. This analysis is based on unclassified text data extracted from German court files. Five topics (latent dimensions) were identified within referral questions resembling cases when the issue was as follows: (a) potential child endangerment in the context of visitation contacts, (b) a possibly limited parenting capacity and its potential effects on child well-being, (c) an impairment of the child has already occurred or could occur, (d) a better option concerning custody and residence, and (e) an unclear topic addressing questions on custody, residence, and visitation in which no specific psychological constructs are involved. In four of the five topics, judges utilize their referral questions to ask for case-group-specific psychological information. In one topic addressing questions on custody, residence, and visitation, judges seem to struggle to define criteria that forensic evaluators should assess. Overall, results help to identify and define more clearly the relevant constructs that forensic experts should examine from the perspective of the courts with the goal of making clearer and more accurate recommendations.
D and D_s meson spectroscopy
Creators: name: Mohler, Daniel
name: Woloshyn, R. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Results are presented for the low-lying spectrum of D and D_s mesons calculated in lattice QCD using 2+1 flavor Clover-Wilson configurations made available by the PACS-CS collaboration. For the heavy quark, the Fermilab method is employed. The main focus is S- and P-wave states of charmed and charmed-strange mesons, where previous lattice QCD results have been mostly from quenched calculations. In addition to the ground states, some excited states are extracted. To check the method, calculations of the charmonium spectrum are also carried out. For charmonium, the low-lying spectrum agrees favorably with experiment. For heavy-strange and heavy-light systems substantial differences in comparison to experiment values remain for some states.
description: 18 pages; updated version reflecting changes during the publishing process
Multitudes of Stable States in a Periodically Driven Electron-Nuclear Spin System in a Quantum Dot
Creators: name: Korenev, V. L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The periodical modulation of circularly polarized light with a frequency close to the electron spin resonance frequency induces a sharp change of the single electron spin orientation. Hyperfine interaction provides a feedback, thus fixing the precession frequency of the electron spin in the external and the Overhauser field near the modulation frequency. The nuclear polarization is bidirectional and the electron-nuclear spin system (ENSS) possesses a few stable states. A similar frequency-locking effect exists for two-color and mode-locked excitations, too. However, the pulsed excitation with mode locked laser brings about the multitudes of stable states in ENSS in a quantum dot. The resulting precession frequencies of the electron spin differ in these states by the multiple of the modulation frequency. Under such conditions ENSS represents a digital frequency converter with more than a hundred stable channels.
description: 28 pages, 4 Figures
Additional file 1 of PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway
Creators: name: Kim, Ji-Eun
name: Lee, Duk-Shin
name: Kim, Tae-Hyun
name: Park, Hana
name: Kim, Min-Ju
name: Kang, Tae-Cheon
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Full-length gel images of Western blots in Fig. 1. Figure S2. Full-length gel images of Western blots in Fig. 2. Figure S3. Full-length gel images of Western blots in Fig. 3. Figure S4. Full-length gel images of Western blots in Fig. 5. Figure S5. Full-length gel images of Western blots in Fig. 7.
Threshold effects on renormalization group running of neutrino parameters in the low-scale seesaw model
Creators: name: Bergstrom, Johannes
name: Ohlsson, Tommy
name: Zhang, He
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that, in the low-scale type-I seesaw model, renormalization group running of neutrino parameters may lead to significant modifications of the leptonic mixing angles in view of so-called seesaw threshold effects. Especially, we derive analytical formulas for radiative corrections to neutrino parameters in crossing the different seesaw thresholds, and show that there may exist enhancement factors efficiently boosting the renormalization group running of the leptonic mixing angles. We find that, as a result of the seesaw threshold corrections to the leptonic mixing angles, various flavor symmetric mixing patterns (e.g., bi-maximal and tri-bimaximal mixing patterns) can be easily accommodated at relatively low energy scales, which is well within the reach of running and forthcoming experiments (e.g., the LHC).
description: 24 pages, 4 figures. Appendix with detailed analytical analysis and comparison with numerical results added. Version published in PLB
Additional file 1 of The relationship between fall incidents and place of birth in residential aged care facilities: a retrospective longitudinal cohort study
Creators: name: Huang, Guogui
name: Wabe, Nasir
name: Raban, Magdalena Z.
name: Seaman, Karla L.
name: Silva, Sandun Malpriya
name: Westbrook, Johanna I.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary Material 1: Table S1. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Male. Table S2. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Female. Table S3. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Age ≤ 85. Table S4. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Age > 85. Table S5. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Permanent Residents. Table S6. Fall Risk of Overseas-born RACF Residents Compared with Australia-born RACF Residents, Respite Residents.
Delineating the Association Between Soluble CD26 and Autoantibodies Against G-Protein Coupled Receptors, Immunological and Cardiovascular Parameters Identifies Distinct Patterns in Post-Infectious vs. Non-Infection-Triggered Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Creators: name: Szklarski, Marvin
name: Freitag, Helma
name: Lorenz, Sebastian
name: Becker, Sonya C.
name: Sotzny, Franziska
name: Bauer, Sandra
name: Hartwig, Jelka
name: Heidecke, Harald
name: Wittke, Kirsten
name: Kedor, Claudia
name: Hanitsch, Leif G.
name: Grabowski, Patricia
name: Sepúlveda, Nuno
name: Scheibenbogen, Carmen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: ME/CFS
subject: chronic fatigue syndrome
subject: CD26
subject: DPP-4
subject: autoantibodies
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Soluble cluster of differentiation 26 (sCD26) has a wide range of enzymatic functions affecting immunological, metabolic and vascular regulation. Diminished sCD26 concentrations have been reported in various autoimmune diseases and also in Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS). Here we re-evaluate sCD26 as a diagnostic marker and perform a comprehensive correlation analysis of sCD26 concentrations with clinical and paraclinical parameters in ME/CFS patients. Though this study did find significantly lower concentrations of sCD26 only in the female cohort and could not confirm diagnostic suitability, results from correlation analyses provide striking pathomechanistic insights. In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. sCD26 concentrations in infection-triggered ME/CFS were found to be associated with activated T cells, liver enzymes, creatin kinase (CK) and lactate dehydrogenase (LDH) and inversely with Interleukin-1 beta (IL-1b). Most associations are in line with the known effects of sCD26/DPP-4 inhibition. Remarkably, in non-infection-triggered ME/CFS lower sCD26 in patients with higher heart rate after orthostatic challenge and postural orthostatic tachycardia syndrome (POTS) suggest an association with orthostatic regulation. These findings provide evidence that the key enzyme sCD26 is linked to immunological alterations in infection-triggered ME/CFS and delineate a different pathomechanism in the non-infectious ME/CFS subset.
Spatiotemporal Correlation of Epileptiform Activity and Gene Expression in vitro
Creators: name: Schlabitz, Sophie
name: Monni, Laura
name: Ragot, Alienor
name: Dipper-Wawra, Matthias
name: Onken, Julia
name: Holtkamp, Martin
name: Fidzinski, Pawel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: epileptiform activity in vitro
subject: 4-aminopyridine
subject: intrinsic optical signals
subject: gene expression
subject: c-Fos
subject: Icer
subject: mTor
subject: cell death
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in gene expression due to epileptiform activity and tested this hypothesis mainly in rodent and additionally in some human brain slices. We focused on three genes relevant for seizures and epilepsy: FOS proto-oncogene (c-Fos), inducible cAMP early repressor (Icer) and mammalian target of rapamycin (mTor). Seizure-like events (SLEs) were induced by 4-aminopyridine (4-AP) in rat entorhinal-hippocampal slices and by 4-AP/8 mM potassium in human temporal lobe slices obtained from surgical treatment of epilepsy. SLEs were monitored simultaneously by extracellular field potentials and intrinsic optical signals (IOS) for 1-4 h, mRNA expression was quantified by real time PCR. In rat slices, both duration of SLE exposure and SLE onset region were associated with increased expression of c-Fos and Icer while no such association was shown for mTor expression. Similar to rat slices, c-FOS induction in human tissue was increased in slices with epileptiform activity. Our results indicate that irrespective of limitations imposed by ex vivo conditions, in vitro models represent a suitable tool to investigate gene expression. Our finding is of relevance for the investigation of human tissue that can only be performed ex vivo. Specifically, it presents an important prerequisite for future studies on transcriptome-wide and cell-specific changes in human tissue with the goal to reveal novel candidates involved in the pathophysiology of epilepsy and possibly other CNS pathologies.
Additional file 4 of Describing the burden of moderate exacerbations in patients with asthma from the Extended Salford Lung Study (Ext-SLS): a retrospective cohort study
Creators: name: Goodall, Emma
name: Rothnie, Kieran J.
name: Numbere, Beade
name: Zhang, Shiyuan
name: Compton, Chris
name: Wood, Robert
name: Tritton, Theo
name: Wild, Rosie
name: Small, Mark
name: Vestbo, Jørgen
name: Woodcock, Ashley
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 4: Figure S4 Sensitivity analyses of self-reported moderate asthma exacerbations (pre-index), by asthma control status (ACT and ACQ-6) at index
Additional file 1 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. siRNA target sequences. Table S2. RT-PCR primers. Table S3. List of transcriptome datasets retrieved from publicly available Gene Expression Omnibus. Table S4. Descriptive statistics.
A cohomological obstruction to weak approximation for homogeneous spaces
Creators: name: Borovoi, Mikhail
name: Schlank, Tomer M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: Primary: 14M17, Secondary: 14G05, 20G10, 20G30

description: Let X be a homogeneous space, X = G/H, where G is a connected linear algebraic group over a number field k, and H is a k-subgroup of G (not necessarily connected). Let S be a finite set of places of k. We compute the Brauer-Manin obstruction to weak approximation for X in S in terms of Galois cohomology.
description: 19 pages. Final version, to appear in Moscow Math. J
HCMV-Mediated Interference of Bortezomib-Induced Apoptosis in Colon Carcinoma Cell Line Caco-2
Creators: name: Härtel, Heike
name: Theiß, Janine
name: Abdelaziz, Mohammed O.
name: Raftery, Martin J.
name: Pecher, Gabriele
name: Bogner, Elke
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: human cytomegalovirus
subject: Caco-2 cells
subject: Bortezomib
subject: apoptosis
subject: necroptosis
subject: co-culture
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Human cytomegalovirus (HCMV) has been implicated in the development of human malignancies, for instance in colon cancer. Proteasome inhibitors were developed for cancer therapy and have also been shown to influence HCMV infection. The aim of this study was to investigate if proteasome inhibitors have therapeutic potential for colon carcinoma and how this is influenced by HCMV infection. We show by immunofluorescence and flow cytometry that the colon carcinoma cell line Caco-2 is susceptible to HCMV infection. Growth curve analysis as well as protein expression kinetics and quantitative genome analysis further confirm these results. HCMV has an anti-apoptotic effect on Caco-2 cells by inhibiting very early events of the apoptosis cascade. Further investigations showed that HCMV stabilizes the membrane potential of the mitochondria, which is typically lost very early during apoptosis. This stabilization is resistant to proteasome inhibitor Bortezomib treatment, allowing HCMV-infected cells to survive apoptotic signals. Our findings indicate a possible role of proteasome inhibitors in colon carcinoma therapy.
Additional file 1 of Association of preoperative anxiety and depression with quality of recovery after caesarean delivery: a prospective observational study
Creators: name: Ishida, Ayu
name: Ida, Mitsuru
name: Kinomoto, Akane
name: Naito, Yusuke
name: Kawaguchi, Masahiko
Publisher: name: figshare
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Mental Health

description: Supplementary Material 1.
Additional file 2 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Figure S1. The effect of inhibition of TAS1R3 by siRNA transfection and antagonist on pro-inflammatory cytokine expression in EECs.
Overly Strong Priors for Socially Meaningful Visual Signals Are Linked to Psychosis Proneness in Healthy Individuals
Creators: name: Stuke, Heiner
name: Kress, Elisabeth
name: Weilnhammer, Veith Andreas
name: Sterzer, Philipp
name: Schmack, Katharina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: face processing
subject: perceptual bias
subject: predictive coding
subject: psychosis proneness
subject: hallucination
subject: gaze detection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: According to the predictive coding theory of psychosis, hallucinations and delusions are explained by an overweighing of high-level prior expectations relative to sensory information that leads to false perceptions of meaningful signals. However, it is currently unclear whether the hypothesized overweighing of priors (1) represents a pervasive alteration that extends to the visual modality and (2) takes already effect at early automatic processing stages. Here, we addressed these questions by studying visual perception of socially meaningful stimuli in healthy individuals with varying degrees of psychosis proneness (n = 39). In a first task, we quantified participants' prior for detecting faces in visual noise using a Bayesian decision model. In a second task, we measured participants' prior for detecting direct gaze stimuli that were rendered invisible by continuous flash suppression. We found that the prior for detecting faces in noise correlated with hallucination proneness (r = 0.50, p = 0.001, Bayes factor 1/20.1) as well as delusion proneness (r = 0.46, p = 0.003, BF 1/9.4). The prior for detecting invisible direct gaze was significantly associated with hallucination proneness (r = 0.43, p = 0.009, BF 1/3.8) but not conclusively with delusion proneness (r = 0.30, p = 0.079, BF 1.7). Our results provide evidence for the idea that overly strong high-level priors for automatically detecting socially meaningful stimuli might constitute a processing alteration in psychosis.
Complete Fermi surface in BaFe$_2$As$_2$ observed via Shubnikov-de Haas oscillation measurements on detwinned single crystals
Creators: name: Terashima, Taichi
name: Kurita, Nobuyuki
name: Tomita, Megumi
name: Kihou, Kunihiro
name: Lee, Chul-Ho
name: Tomioka, Yasuhide
name: Ito, Toshimitsu
name: Iyo, Akira
name: Eisaki, Hiroshi
name: Liang, Tian
name: Nakajima, Masamichi
name: Ishida, Shigeyuki
name: Uchida, Shin-ichi
name: Harima, Hisatomo
name: Uji, Shinya
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that the Fermi surface (FS) in the antiferromagnetic phase of BaFe$_2$As$_2$ is composed of one hole and two electron pockets, all of which are three dimensional and closed, in sharp contrast to the FS observed by angle-resolved photoemission spectroscopy. Considerations on the carrier compensation and Sommerfeld coefficient rule out existence of unobserved FS pockets of significant sizes. A standard band structure calculation reasonably accounts for the observed FS, despite the overestimated ordered moment. The mass enhancement, the ratio of the effective mass to the band mass, is 2--3.
description: Supplemental Material added. Published in Phys. Rev. Lett
Lower IgA Levels in Chronic Spontaneous Urticaria Are Associated With Lower IgE Levels and Autoimmunity
Creators: name: Sauer, Merle
name: Scheffel, Jörg
name: Frischbutter, Stefan
name: Kolkhir, Pavel
name: Xiang, Yi-Kui
name: Siebenhaar, Frank
name: Altrichter, Sabine
name: Maurer, Marcus
name: Metz, Martin
name: Krause, Karoline
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: immunoglobulin A
subject: immunoglobulin E
subject: chronic spontaneous urticaria
subject: autoreactivity
subject: autoimmune disease
subject: basophils
subject: eosinophils
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The pathogenesis of chronic spontaneous urticaria (CSU) is still insufficiently understood. Recent findings suggest that immunoglobulins, in particular IgE but also IgA, play a role in the development of CSU. Objective: Our aim was to assess differences in clinical and laboratory markers between CSU patients with and without lower levels of serum IgA and IgE. Methods: We analyzed the data of 606 patients with CSU by dividing them into four groups based on their IgA and IgE levels. The groups were compared for their spectrum of symptoms, disease activity, concomitant autoimmunity and routine laboratory markers. Autoreactivity was assessed by basophil activation test (BAT). Moreover, IgE-anti-thyroid peroxidase (TPO) was measured. Results: Of the patients with lower IgE levels, 66.5% also had lower IgA levels (r=0.316, p<0.001). Patients with lower IgA and lower IgE levels showed a higher prevalence of recurrent angioedema (p=0.03, p=0.04) and concomitant autoimmunity (p=0.006, p<0.001). Autoreactivity was also found more frequently in patients with lower IgA and lower IgE levels (p=0.003, p<0.001). Reduced basophil counts were linked to both, lower IgA and lower IgE levels (p<0.001), whereas low eosinophil counts were primarily present in patients with lower IgE levels (p=0.04, p<0.001). Patients with elevated IgE-anti-TPO levels had lower IgA (p=0.007) and IgE levels (p=0.001). Conclusion: Lower IgA levels in CSU are linked to lower IgE levels and features of autoimmune urticaria. Our findings encourage to screen CSU patients for serum IgA and IgE levels and to further assess their role as disease biomarkers.
Additional file 3 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Figure S2. Comparison of caloric intake of Tas1r3−/− and Tas1r3+/+ mice fed WD or ND for 10 weeks ad libitum.
Additional file 1 of Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder
Creators: name: Gumusoglu, Serena B.
name: Schickling, Brandon M.
name: Santillan, Donna A.
name: Teesch, Lynn M.
name: Santillan, Mark K.
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 1
Additional file 4 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 4: Figure S3. The effect of TAS1R3 deficiency on intestinal inflammation in a murine DSS-colitis model.
On the birational geometry of the universal Picard variety
Creators: name: Bini, Gilberto
name: Fontanari, Claudio
name: Viviani, Filippo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14H10

description: We compute the Kodaira dimension of the universal Picard variety P_{d,g} parameterizing line bundles of degree d on curves of genus g under the assumption that (d-g+1,2g-2)=1. We also give partial results for arbitrary degrees d and we investigate for which degrees the universal Picard varieties are birational.
description: 34 pages, 1 figure, final version (to appear in IMRN)
First passage time statistics of Brownian motion with purely time dependent drift and diffusion
Creators: name: Molini, Annalisa
name: Talkner, Peter
name: Katul, Gabriel G.
name: Porporato, Amilcare
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Systems where resource availability approaches a critical threshold are common to many engineering and scientific applications and often necessitate the estimation of first passage time statistics of a Brownian motion (Bm) driven by time-dependent drift and diffusion coefficients. Modeling such systems requires solving the associated Fokker-Planck equation subject to an absorbing barrier. Transitional probabilities are derived via the method of images, whose applicability to time dependent problems is shown to be limited to state-independent drift and diffusion coefficients that only depend on time and are proportional to each other. First passage time statistics, such as the survival probabilities and first passage time densities are obtained analytically. The analysis includes the study of different functional forms of the time dependent drift and diffusion, including power-law time dependence and different periodic drivers. As a case study of these theoretical results, a stochastic model for water availability from surface runoff in snowmelt dominated regions is presented, where both temperature effects and snow-precipitation input are incorporated.
Additional file 5 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5: Figure S4. Schematic depicting the roles of TAS1R3 in the intestinal inflammation.
Boij-Söderberg theory: Introduction and survey
Creators: name: Floystad, Gunnar
Publisher: name: arXiv
Year: 2011
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13D02, 14F05 (Primary) 13C14, 14N99 (Secondary)

description: Boij-Söderberg theory describes the Betti diagrams of graded modules over the polynomial ring up to multiplication by a rational number. Analog Eisenbud-Schreyer theory also describes the cohomology tables of vector bundles on projective spaces up to rational multiple. We give an introduction and survey of these newly developed areas.
description: Minor corrections. 47 pages, to appear in Progress in Commutative Algebra: Ring Theory, Homology, and Decomposition, eds. C.Francisco et.al
Figshare - Working with DataCite
Creators: name: Hahnel, Mark
Publisher: name: Zenodo
Year: 2021
Subjects: DataCite Member Meeting 2021
Service Provider
DOI
Figshare

description: DataCite launched its registered service providers program in 2020, in order to ensure that members have access to high-quality DataCite integrations that support DOI registration best practices. To date, 10 developers/vendors have been registered https://datacite.org/service-providers.html (and more are on on the way!)
 This presentation by Mark Hahnel (Figshare) provides insights into how Figshare and DataCite are working together. A recording of the presentation can be found at: https://youtu.be/O0uOLgsqZ2U?t=1915
Precision of electromagnetic control of a quantum system
Creators: name: Chan, Ching-Kit
name: Sham, L. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Coherent control of a spin is limited by both the decoherence due to coupling with the environment and noise coming from the quantized control. The quantum noise study of this system is particularly important in fault tolerant quantum computation where a very high fidelity is demanded. Here, we present a time evolution study of a two level system (TLS) interacting with a laser pulse and the electromagnetic vacuum based on the multimode Jaynes-Cummings model. We develop a diagrammatic formalism in which one can easily identify the coherent Rabi oscillation of the TLS and its relaxation from corresponding diagrams. In the small time limit ($t\ll T_1$), where the noise level is small but still an issue to fault tolerant quantum computing, this method gives a quantitative evaluation of the quantum noise of the TLS under an optical control with an arbitrary pulse shape. Furthermore, this approach can be naturally extended from the Markovian to the non-Markovian regime, resulting in dynamics different from that obtained in the optical Bloch analysis. All these calculations are done without any stochastic assumption.
description: 10 pages, 8 figures
Additional file 6 of Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Creators: name: Shon, Woo-Jeong
name: Song, Jae Won
name: Oh, Seung Hoon
name: Lee, Keon-Hee
name: Seong, Hobin
name: You, Hyun Ju
name: Seong, Je Kyung
name: Shin, Dong-Mi
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 6. Uncropped western blot figures.
Additional file 1 of A scoping review of the methods used to estimate health facility catchment populations for child health indicators in sub-Saharan Africa
Creators: name: Johnson, Matthew
name: Adewole, Wole Ademola
name: Alegana, Victor
name: Utazi, C. Edson
name: McGrath, Nuala
name: Wright, James
Publisher: name: figshare
Year: 2025
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Supplementary material 1.