cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Acute Pancreatitis Secondary to Diabetic Ketoacidosis Induced Hypertriglyceridemia in a Young Adult with Undiagnosed Type 2 Diabetes
Creators: name: Singla, Animesh A
name: Ting, Francis
name: Singla, Apresh
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Diabetic Ketoacidosis; Hypertriglyceridemia; Pancreatitis

description: Context The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. Case report A previously well 19-year-old male presented to the emergency department with 24-hour history of epigastric pain, associated with polyuria and nausea. Biochemical markers showed the presence of hyperglycemia (blood sugar level 15 mmol/L) and ketonemia (5.3 mmol/L). Further investigation revealed severe hypertriglyceridemia (4,009 mg/dL) and elevated lipase (1,714 U/L). Abdominal ultrasound confirmed the diagnosis of acute pancreatitis. He was transferred to intensive care, where he received i.v. hydration, insulin and dextrose infusion. His metabolic derangements gradually resolved. His glycosylated hemoglobin was 13%, indicating the presence of chronically elevated blood sugars. Conclusion The possible pathophysiology and management of this unusual triad: diabetic ketoacidosis, hypertriglyceridemia and acute pancreatitis, are explored in this paper.

Image: Edematous pancreas and adjacent fluid collection.
description: JOP. Journal of the Pancreas, Vol 16, No 2 (2015): March - p. 99-217
Market Implementation of Multiple-Arrival Multiple-Deadline Differentiated Energy Services
Creators: name: Mo, Yanfang
name: Chen, Wei
name: Qiu, Li
name: Varaiya, Pravin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Systems and Control (eess.SY)
subject: General Economics (econ.GN)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Economics and business

description: An increasing concern in power systems is how to elicit flexibilities in demand, which leads to nontraditional electricity products for accommodating loads of different flexibility levels. We have proposed Multiple-Arrival Multiple-Deadline (MAMD) differentiated energy services for the flexible loads which require constant power for specified durations. Such loads are indifferent to the actual power delivery time as long as the duration requirements are satisfied between the specified arrival times and deadlines. The focus of this paper is the market implementation of such services. In a forward market, we establish the existence of an efficient competitive equilibrium to verify the economic feasibility, which implies that selfish market participants can attain the maximum social welfare in a distributed manner. We also show the strengths of the MAMD services by simulation.
description: 14 pages, 5 figures
Seventy-two Cycles of FOLFIRINOX: Long Term Treatment in a Patient with Metastatic Adenocarcinoma of the Pancreatic Tail
Creators: name: Tiller, Maximilian
name: Gundling, Felix
name: Schepp, Wolfgang
name: Fuchs, Martin
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Adenocarcinoma

description: Context Pancreatic adenocarcinoma is one of the most lethal malignancies worldwide. In patients with unresectable tumor there are several strategies of palliative chemotherapy, either gemcitabine based regimens or FOLFIRINOX, which is supposed to be most efficient but also most toxic. Hence, management of toxicity is crucial to perform a therapy consisting of FOLFIRINOX. Case report We report on a 69-year-old female patient suffering from adenocarcinoma of the pancreatic tail with multiple liver metastases. Palliative chemotherapy comprising leucovorin, fluorouracil, oxaliplatin and irinotecan (FOLFIRINOX) was initiated in February 2011 and was tolerated very well. Subsequent computed tomography–scans showed significant reduction of the tumor load in the liver as well as in the primary pancreatic tumor. The serum levels of the tumor marker CA 19-9 were elevated initially and decreased concomitantly. Thus, chemotherapy was continued for more than 3 years, and up to 72 cycles were administered until April 2014. Due to intermittent neutropenia and mucositis the initial dose was reduced to 60% of the calculated standard dose. In April 2014, an intermediate staging by computed tomography and FDG-PET revealed significant reduction of the size of the primary pancreatic tumor compared with February 2011. Liver metastases could hardly be detected anymore. After pausing chemotherapy for 12 weeks, one liver metastasis reappeared and was treated by RFA in August 2014. Meanwhile, in October 2014 there is no radiological evidence on any existing tumor or metastasis. Conclusion Our report demonstrates that a sufficient tolerance of chemotherapy with FOLFIRINOX is achievable, what makes a long term treatment with FOLFIRINOX feasible and can lead to impressive results.

Image: Laboratory parameters during chemotherapy.
description: JOP. Journal of the Pancreas, Vol 16, No 2 (2015): March - p. 99-217
Gold Reliquary Cross
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: 2006BC6621_jpg_l and 2006BC6622_jpg_l. The cross is one of the rare surviving pieces which give substance to descriptions in contemporary documentary sources of the sumptuous church furnishings of pre-Conquest England. The enamels are unique in Anglo-Saxon art and may have been made by an English goldsmith familiar with German work. A fragmentary and not totally legible inscription around the edge of the cross seems to list the relics of saints once contained in the cavity beneath the ivory figure of Christ. This ivory figure was temporarily removed in 1926 for the purpose of being photographed and cast. Beneath it, lying in a hollow cut in the wood approximately 8.5 cm long, 2 cm wide and 1 cm deep was a dried human finger (perhaps a female index finger) pointing downwards with its outer surface to the front. Despite Papal disapproval of the dismemberment of saints, a finger relic was by no means unusual in Anglo-Saxon England: King Athelstan bestowed one third of his extensive collection of relics to the monastery of St. Mary and St. Peter at Exeter in AD 932. The gift included a finger, purportedly that of Mary Magdalene. All these images are Â© V&A Images/Victoria and Albert Museum, London. These free low-resolution images are covered also under the museum's Terms and Conditions (http://collections.vam.ac.uk/information/information_termsandconditions). The full image collection is available at: http://www.vam.ac.uk and http://collections.vam.ac.uk/ where you can also order high resolution copies.
Reply to “Comments on the Article: Management of Suspected Acute Inflammatory Pancreatopathies in a "Real-World" Setting - A Single-Centre Observational Study”
Creators: name: De Nuzzo, Daniele
name: Miconi, Alessia
name: Pierantognetti, Paola
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Abdominal Pain; Comment; Disease Management; Letter; Pancreatic Diseases; Pancreatitis, Acute Necrotizing

description: No abstract available.

Image: University of Rome “Sapienza”. Rome, Italy
description: JOP. Journal of the Pancreas, Vol 16, No 2 (2015): March - p. 99-217
Finger Ring
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: 2008BT1996_jpg_l. In contrast to the rich garnet-set jewellery of the earlier Anglo-Saxon period, finger rings of the ninth century are rarely adorned with precious stones. The skills of the goldsmith are seen in this example, where the different techniques of filigree and granulation are combined to produce an elaborately decorated ring. All these images are Â© V&A Images/Victoria and Albert Museum, London. These free low-resolution images are covered also under the museum's Terms and Conditions (http://collections.vam.ac.uk/information/information_termsandconditions). The full image collection is available at: http://www.vam.ac.uk and http://collections.vam.ac.uk/ where you can also order high resolution copies.
Sprawozdanie z Hawaii International Conference on Art & Humanities, Honolulu 10-14. 01. 2008 r.
Creators: name: Wyrzykowska, Małgorzata
Publisher: name: Quart
Year: 2019

description: Quart, Bd. 7 Nr. 1 (2008): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Numerical algorithm for the space-time fractional Fokker-Planck system with two internal states
Creators: name: Nie, Daxin
name: Sun, Jing
name: Deng, Weihua
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The fractional Fokker-Planck system with multiple internal states is derived in [Xu and Deng, Math. Model. Nat. Phenom., $\mathbf{13}$, 10 (2018)], where the space derivative is Laplace operator. If the jump length distribution of the particles is power law instead of Gaussian, the space derivative should be replaced with fractional Laplacian. This paper focuses on solving the two state Fokker-Planck system with fractional Laplacian. We first provide a priori estimate for this system under different regularity assumptions on the initial data. Then we use $L_1$ scheme to discretize the time fractional derivatives and finite element method to approximate the fractional Laplacian operators. Furthermore, we give the error estimates for the space semidiscrete and fully discrete schemes without any assumption on regularity of solutions. Finally, the effectiveness of the designed scheme is verified by numerical experiments.
description: 29 pages
Finger Ring
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: 2008BT1996_jpg_l. In contrast to the rich garnet-set jewellery of the earlier Anglo-Saxon period, finger rings of the ninth century are rarely adorned with precious stones. The skills of the goldsmith are seen in this example, where the different techniques of filigree and granulation are combined to produce an elaborately decorated ring. All these images are Â© V&A Images/Victoria and Albert Museum, London. These free low-resolution images are covered also under the museum's Terms and Conditions (http://collections.vam.ac.uk/information/information_termsandconditions). The full image collection is available at: http://www.vam.ac.uk and http://collections.vam.ac.uk/ where you can also order high resolution copies.
Czterej panowie ilustratorzy, nie licząc zwierząt
Creators: name: Wincencjusz-Patyna, Anita
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 8 Nr. 2 (2008): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Hierarchical Event-triggered Learning for Cyclically Excited Systems with Application to Wireless Sensor Networks
Creators: name: Beuchert, Jonas
name: Solowjow, Friedrich
name: Raisch, Jörg
name: Trimpe, Sebastian
name: Seel, Thomas
Publisher: name: arXiv
Year: 2019
Subjects: subject: Systems and Control (eess.SY)
subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Communication load is a limiting factor in many real-time systems. Event-triggered state estimation and event-triggered learning methods reduce network communication by sending information only when it cannot be adequately predicted based on previously transmitted data. This paper proposes an event-triggered learning approach for nonlinear discrete-time systems with cyclic excitation. The method automatically recognizes cyclic patterns in data - even when they change repeatedly - and reduces communication load whenever the current data can be accurately predicted from previous cycles. Nonetheless, a bounded error between original and received signal is guaranteed. The cyclic excitation model, which is used for predictions, is updated hierarchically, i.e., a full model update is only performed if updating a small number of model parameters is not sufficient. A nonparametric statistical test enforces that model updates happen only if the cyclic excitation changed with high probability. The effectiveness of the proposed methods is demonstrated using the application example of wireless real-time pitch angle measurements of a human foot in a feedback-controlled neuroprosthesis. The experimental results show that communication load can be reduced by 70 % while the root-mean-square error between measured and received angle is less than 1°.
description: 6 pages and 6 figures; to appear in IEEE Control Systems Letters
Supplementary Material from A microscopic Burgess Shale: Small Carbonaceous Fossils (SCFs) from a deeper-water biota and the distribution of Cambrian nonmineralised faunas
Creators: name: Mussini, Giovanni
name: Butterfield, Nick
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 370506
subject: Palaeontology (incl. palynology)

description: Supplementary materials including descriptions and figures of non-metazoan and taxonomically problematic Small Carbonaceous Fossils (SCFs) from the Hess River biota.
'Enthüllungen
Creators: name: Kaczmarek, Romuald
Publisher: name: Quart
Year: 2019

description: Rezension zu: 'Enthüllungen. Restaurierte Kunstwerke von Riemenschneider bis Kremser Schmidt', Germanisches Nationalmuseum, Nürnberg 19.10.2008 – 25.1.2009, (Projektleitung: F.M. Kammel, D. Hess. Ausstellungs- und Schriftleitung: F.M. Kammel. Redaktion: Ch. Kupper), Nürnberg 2008, ss. 127 Includes a summary in English
description: Quart, Bd. 10 Nr. 4 (2008): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
'Das Riesengebirge. Die Künstlerkolonie Schreiberhau'
Creators: name: Jezierska, Anna
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 11 Nr. 1 (2009): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Control-guided Communication: Efficient Resource Arbitration and Allocation in Multi-hop Wireless Control Systems
Creators: name: Baumann, Dominik
name: Mager, Fabian
name: Zimmerling, Marco
name: Trimpe, Sebastian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Systems and Control (eess.SY)
subject: Multiagent Systems (cs.MA)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: In future autonomous systems, wireless multi-hop communication is key to enable collaboration among distributed agents at low cost and high flexibility. When many agents need to transmit information over the same wireless network, communication becomes a shared and contested resource. Event-triggered and self-triggered control account for this by transmitting data only when needed, enabling significant energy savings. However, a solution that brings those benefits to multi-hop networks and can reallocate freed up bandwidth to additional agents or data sources is still missing. To fill this gap, we propose control-guided communication, a novel co-design approach for distributed self-triggered control over wireless multi-hop networks. The control system informs the communication system of its transmission demands ahead of time, and the communication system allocates resources accordingly. Experiments on a cyber-physical testbed show that multiple cart-poles can be synchronized over wireless, while serving other traffic when resources are available, or saving energy. These experiments are the first to demonstrate and evaluate distributed self-triggered control over low-power multi-hop wireless networks at update rates of tens of milliseconds.
description: Accepted final version to appear in: IEEE Control Systems Letters
Solid-Pseudopapillary Neoplasm of the Pancreas: Case Series and Literature Review
Creators: name: Alves, José Roberto
name: Amico, Enio Campos
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Cystadenoma; Cystadenocarcinoma; Pancreas; Pancreatic Neoplasm

description: The solid-pseudopapillary neoplasm of the pancreas is a rare disease, although since 2000, it has been often identified. The current study aims to present a 10-case series of solid-pseudopapillary neoplasm of the pancreas and a literature review on the topic. The cohort consisted of nine female patients and one male. The mean age in the group was 31.2 year-old. These patients underwent surgical treatment at the University Hospital between May 2007 and July 2014. Since there was a previous systematic literature review on solid-pseudopapillary neoplasm of the pancreas (prior to September 20th, 2012), a complementary review was done after this period using PubMed’s data base. The search identified 225 studies on this subject, but only 13 were selected for detailed analysis, after applying the inclusion and exclusion criteria. As a result, most of the information about the disease’s epidemiology, clinical manifestations, malignity risk factors, metastasis and relapse were gathered, however, early diagnosis remained a challenge. Radical surgical resection is established as the standard treatment protocol for the disease, it is also recommended to perform metastasectomy, vascular resections and/or resections of other compromised organs in order to ensure therapeutic success in 95% of the cases. However, a post-operative follow up of at least 5 years is required to identify the possibility of relapses. Further studies are still needed mainly to define this disease’s true prevalence among men, protocols for early diagnosis and the possible role of adjuvant therapies.

Image: Intraoperative picture demonstrating a SPN in pancreatic head attached to the portal vein.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Ivory Cross
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: The delicately carved archer on the lid of this cross probably represents a figure from the Old Testament: Ishmael, son of Abraham. The reverse shows the Lamb of God surrounded by the four symbols of the evangelists. The cross originally formed a case for a gold box, perhaps containing relics of the True Cross. All these images are © V&A Images/Victoria and Albert Museum, London. These free low-resolution images are covered also under the museum's Terms and Conditions (http://collections.vam.ac.uk/information/information_termsandconditions). The full image collection is available at: http://www.vam.ac.uk and http://collections.vam.ac.uk/ where you can also order high resolution copies.
'Um in die innern Räume die erwünschte Harmonie zu tragen'
Creators: name: Lubos-Kozieł, Joanna
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 12 Nr. 2 (2009): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Pancreatic Steatosis: What Should Gastroenterologists Know?
Creators: name: Prachayakul, Varayu
name: Aswakul, Pitulak
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Pancreas

description: When hyperechoic pancreatic parenchyma is observed on endoscopic or transabdominal ultrasound, fat infiltration of the pancreas is suspected. This condition was first reported by Ogilvie in 1993 and is termed fatty pancreas, pancreatic lipomatosis, non-alcoholic fatty pancreas, or pancreatic steatosis. Diagnosis of this condition mostly relies on imaging tools such as magnetic resonance imaging, computed tomography, or ultrasonography rather than histology. Although the condition is rare, it has clinical significance. There are multiple hypotheses regarded the etiology of this condition, listing factors such as viral infections, toxins, and congenital syndromes as possible causes. Metabolic syndrome and diabetes mellitus correlated with this condition. However, other etiologies should also be considered to aid specific treatment. In addition to a correlation between pancreatic steatosis and metabolic syndrome, relationships between pancreatic steatosis and worsened severity and prognosis of pancreatic cancer, increased complications after pancreatic surgery, and acute pancreatitis were reported. Gastroenterologists should be well informed about this condition for better care of these patients.

Image: Siriraj Hospital. Bangkok, Thailand.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Demicryptochironomus undetermined
Creators: name: Armitage, Brian J.
name: Andersen, Trond
name: Giłka, Wojciech
name: Castillo Sánchez, Kayla N.
name: Ríos González, Tomás A.
name: Aguirre, Yusseff P.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Demicryptochironomus
Demicryptochironomus undetermined

description: Demicryptochironomus sp. *
Material examined. Panama, Chiriquí Province, Cuenca 108, Boquete District, Quebrada Jaramillo Abajo, 3 males, 14 November 2018, UV light trap, leg K. Castillo; as previous except 1 male, 6 February 2019.
description: Published as part of Armitage, Brian J., Andersen, Trond, Giłka, Wojciech, Castillo Sánchez, Kayla N., Ríos González, Tomás A. & Aguirre, Yusseff P., 2025, The Diptera of Panama. II. A first benchmark for the family Chironomidae, pp. 201-240 in Zootaxa 5613 (2) on page 209, DOI: 10.11646/zootaxa.5613.2.1, http://zenodo.org/record/15224174
title: Aufbau von modernen Datenplattformen in der Cloud - Überblick und Umsetzung von Modern Data Warehouse, Data Lakehouse und Data Mesh
Creators: name: Benedict, Schröter
Publisher: name: Hochschulbibliothek der Technischen Hochschule Köln
Year: 2025
Subjects: subject: 000 Allgemeines, Wissenschaft

description: Die vorliegende Masterarbeit untersucht die aktuellen Architekturkonzepte für den Aufbau einer Cloud-Datenplattform. Dabei werden die Konzepte Modern Data Warehouse, Data Lakehouse und Data Mesh anhand aktueller Literatur evaluiert. Zur Herstellung eines Praxisbezugs werden diese Konzepte im Kontext der führenden Technologieanbieter Azure, AWS, Databricks und Snowflake analysiert und die entsprechenden Komponenten zur Umsetzung der Konzepte erörtert. 

This master's thesis examines the current architectural concepts for building
description: This master's thesis examines the current architectural concepts for building a cloud data platform. The concepts of Modern Data Warehouse, Data Lakehouse and Data Mesh are evaluated on the basis of current literature. To establish a practical reference, these concepts are analyzed in the context of the leading technology providers Azure, AWS, Databricks and Snowflake and the corresponding components for implementing the concepts are discussed.
A Distributed Event-Triggered Control Strategy for DC Microgrids Based on Publish-Subscribe Model Over Industrial Wireless Sensor Networks
Creators: name: Alavi, Seyed Amir
name: Mehran, Kamyar
name: Hao, Yang
name: Rahimian, Ardavan
name: Mirsaeedi, Hamed
name: Vahidinasab, Vahid
Publisher: name: arXiv
Year: 2019
Subjects: subject: Signal Processing (eess.SP)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Multiagent Systems (cs.MA)
subject: Networking and Internet Architecture (cs.NI)
subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: This paper presents a complete design, analysis, and performance evaluation of a novel distributed event-triggered control and estimation strategy for DC microgrids. The primary objective of this work is to efficiently stabilize the grid voltage, and to further balance the energy level of the energy storage (ES) systems. The locally-installed distributed controllers are utilised to reduce the number of transmitted packets and battery usage of the installed sensors, based on a proposed event-triggered communication scheme. Also, to reduce the network traffic, an optimal observer is employed which utilizes a modified Kalman consensus filter (KCF) to estimate the state of the DC microgrid via the distributed sensors. Furthermore, in order to effectively provide an intelligent data exchange mechanism for the proposed event-triggered controller, the publish-subscribe communication model is employed to setup a distributed control infrastructure in industrial wireless sensor networks (WSNs). The performance of the proposed control and estimation strategy is validated via the simulations of a DC microgrid composed of renewable energy sources (RESs). The results confirm the appropriateness of the implemented strategy for the optimal utilization of the advanced industrial network architectures in the smart grids.
Pancreatic Tuberculosis: An Overview
Creators: name: Miri, Mohammad Bagher
name: Safari, Mohammad Taghi
name: Alizadeh, Amir Houshang Mohammad
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Pancreas

description: Pancreatic tuberculosis is a rare occurrence in either immune-competent or immune-suppressed host. Pancreatic tuberculosis most commonly afflicts the region of the head and the uncinate process of the pancreas. It is often misdiagnosed due to low index of suspicion and masquerading of its symptoms as more common pancreatic conditions such as pancreatic malignancy. However, Endoscopic ultrasound fine needle aspiration sampling with an acid-fast smear is essential for establishing the diagnosis of pancreatic tuberculosis. If the diagnosis is delayed, pancreatic tuberculosis can be fatal. Pancreatic tuberculosis responds well to standard anti-tuberculous drugs.

Image: Taleghani Hospital. Tehran, Iran.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Laplacian Spectral Basis Functions
Creators: name: Patanè, G.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Graphics (cs.GR)
subject: Numerical Analysis (math.NA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Representing a signal as a linear combination of a set of basis functions is central in a wide range of applications, such as approximation, de-noising, compression, shape correspondence and comparison. In this context, our paper addresses the main aspects of signal approximation, such as the definition, computation, and comparison of basis functions on arbitrary 3D shapes. Focusing on the class of basis functions induced by the Laplace-Beltrami operator and its spectrum, we introduce the diffusion and Laplacian spectral basis functions, which are then compared with the harmonic and Laplacian eigenfunctions. As main properties of these basis functions, which are commonly used for numerical geometry processing and shape analysis, we discuss the partition of the unity and non-negativity; the intrinsic definition and invariance with respect to shape transformations (e.g., translation, rotation, uniform scaling); the locality, smoothness, and orthogonality; the numerical stability with respect to the domain discretisation; the computational cost and storage overhead. Finally, we consider geometric metrics, such as the area, conformal, and kernel-based norms, for the comparison and characterisation of the main properties of the Laplacian basis functions.
A sparse spectral method for Volterra integral equations using orthogonal polynomials on the triangle
Creators: name: Gutleb, Timon S.
name: Olver, Sheehan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N35, 45D05

description: We introduce and analyse a sparse spectral method for the solution of Volterra integral equations using bivariate orthogonal polynomials on a triangle domain. The sparsity of the Volterra operator on a weighted Jacobi basis is used to achieve high efficiency and exponential convergence. The discussion is followed by a demonstration of the method on example Volterra integral equations of the first and second kind with known analytic solutions as well as an application-oriented numerical experiment. We prove convergence for both first and second kind problems, where the former builds on connections with Toeplitz operators.
description: 24 pages, 4 figures
Autoimmune Pancreatitis: A Succinct Overview
Creators: name: Putra, Juan
name: Liu, Xiaoying
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Epidemiology

description: Autoimmune pancreatitis is a rare type of chronic pancreatitis with characteristic clinical, radiologic, and histopathologic findings. Diagnosis of autoimmune pancreatitis is often challenging due to its low incidence and nonspecific clinical and radiologic findings. Patients with autoimmune pancreatitis and pancreatic cancer share similar clinical presentations, including obstructive jaundice, abdominal pain and weight loss. Due to these overlapping features, autoimmune pancreatitis patients are often misdiagnosed with pancreatic cancer and undergo unnecessary surgery. International consensus diagnostic criteria for autoimmune pancreatitis lists 5 cardinal features to establish the diagnosis of autoimmune pancreatitis. These features include imaging, serology, other organ involvement, histopathology of the pancreas, and response to steroid therapy. Endoscopic ultrasound-guided fine needle aspiration is a routine diagnostic tool for pancreatic lesions. It is usually utilized to exclude a malignant process in autoimmune pancreatitis patients, since its role to establish a definitive diagnosis of autoimmune pancreatitis is often limited. Endoscopic ultrasound-guided-tru-cut biopsy and endoscopic ultrasound-guided fine needle using a large gauge needle (19 to 22 gauges) have been the preferred methods to obtain tissue samples for histologic evaluation. Lymphoplasmacytic infiltrates, fibrotic stroma, mildly atypical epithelial cells, periphlebitis, and obliterative periphlebitis are the common histologic findings of type 1 autoimmune pancreatitis. Meanwhile, granulocytic pancreatic ductal epithelial damage and ductal obliteration are the histologic characteristics of type 2 autoimmune pancreatitis. Immunohistochemical and molecular studies may be helpful to support the diagnosis of AIP in biopsy materials.
Image: Permanent section of the fine needle aspirate showing venulitis.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Ivory Cross
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: The delicately carved archer on the lid of this cross probably represents a figure from the Old Testament: Ishmael, son of Abraham. The reverse shows the Lamb of God surrounded by the four symbols of the evangelists. The cross originally formed a case for a gold box, perhaps containing relics of the True Cross. All these images are © V&A Images/Victoria and Albert Museum, London. These free low-resolution images are covered also under the museum's Terms and Conditions (http://collections.vam.ac.uk/information/information_termsandconditions). The full image collection is available at: http://www.vam.ac.uk and http://collections.vam.ac.uk/ where you can also order high resolution copies.
Advances in Pancreatic Cancer: The Role of Metabolomics
Creators: name: Nguyen, Vy
name: Hurton, Scott
name: Ayloo, Subhashini
name: Molinari, Michele
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Early Diagnosis; Early Detection of Cancer; Metabolomics; Pancreatic Neoplasms

description: Metabolomics is an emerging scientific field focusing on compounds, also known as metabolomes that are produced by biologic systems. Metabolomes represent phenotypic end-products of living entities, and are of particular interest as they represent a novel group of biomarkers that can be used for diagnosis, monitoring response to treatments, and more recently as potential therapeutic agents for benign but more so for malignant diseases. One of the main factors associated with improved survival of patients affected by malignancies is early diagnosis, particularly for those tumors with poor prognosis such as pancreatic cancer. Currently, there are no diagnostic tests for the screening of pancreatic cancer, and although novel biomarkers continue to be discovered, none has yet to be proven useful for this purpose. The main aims of this paper are to review the current literature and to summarize the most relevant advances in the field of metabolomics applied to pancreatic adenocarcinoma.
Image: Dalhousie University. Halifax, Nova Scotia, Canada.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Coupled Optoelectronic Simulation and Optimization of Thin-Film Photovoltaic Solar Cells
Creators: name: Anderson, Tom H.
name: Civiletti, Benjamin J.
name: Monk, Peter
name: Lakhtakia, Akhlesh
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: A design tool was formulated for optimizing the efficiency of inorganic, thin-film, photovoltaic solar cells. The solar cell can have multiple semiconductor layers in addition to antireflection coatings, passivation layers, and buffer layers. The solar cell is backed by a metallic grating which is periodic along a fixed direction. The rigorous coupled-wave approach is used to calculate the electron-hole-pair generation rate. The hybridizable discontinuous Galerkin method is used to solve the drift-diffusion equations that govern charge-carrier transport in the semiconductor layers. The chief output is the solar-cell efficiency which is maximized using the differential evolution algorithm to determine the optimal dimensions and bandgaps of the semiconductor layers.
Stanisław Szukalski: projekt pomnika Krzysztofa Kolumba, sztuka prekolumbijska i poszukiwanie „nowych alfabetycznych wartości”
Creators: name: Chudzicka, Dorota
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 22 Nr. 4 (2011): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
A computational fluid dynamics study of mass transfer in a large-scale aerated stirred bioreactor☆
Creators: name: Jamshidian, Roya
name: Scully, James
name: Van den Akker, Harry
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 40
subject: Engineering

description: Computational Fluid Dynamics (CFD) is exploited to study mass transfer in a specific stirred aerated bioreactor used in a cell culture process. The focus is on which empirical correlations from the literature can best be used for calculating the volumetric mass transfer coefficient kLa on the basis of the spatially distributed and/or average energy dissipation rate obtained in CFD simulations. This energy dissipation rate plays a key role in many of the empirical correlations which are reviewed in detail. CFD simulations are carried out using the finite volume (FV) ANSYS Fluent software as well as the Lattice Boltzmann (LB)-based code marketed by M− Star. In Fluent, we opted for a two-fluid approach and the realizable k − ε turbulence model, while M− Star models the turbulence by a Large Eddy Simulation and tracks individual bubbles in a Lagrangian way. Gassed power draw, air volume fraction, energy dissipation rate, and (kLa) are calculated in both codes and compared mutually as well as to experimentally measured data and analytical correlations available in the literature. The energy dissipation rate was underpredicted by Fluent, leading to lower breakup rates and an underprediction of kLa. The M− Star simulations also underpredict kLa although predicting much higher levels of energy dissipation. However, using a constant value for kL and just the volume-averaged a from Fluent or M− Star improved the results significantly, which then are in good agreement with the experimental kLa value.
Future Directions in Pancreatic Cancer Therapy
Creators: name: Orchard-Webb, David
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Drug Therapy, Combination; Immunotherapy; Oncolytic Virotherapy; Pancreatic Neoplasms

description: Pancreatic cancer is a major disease burden that is essentially incurable at present. However significant understanding of the molecular basis of pancreatic cancer has been achieved through sequencing. This is allowing the rational design of therapeutics. The purpose of this review is to introduce the molecular basis of pancreatic cancer, explain the current state of molecular therapy and provide examples of the ongoing developments. These include improvements in chemotherapy, small molecule inhibitors, vaccines, immune checkpoint antibodies, and oncolytics.
Image: University of Leeds. Leeds, UK.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Acquired 5-Fluorouracil Resistance in Human Pancreatic Carcinoma Cells. A Paradigm for Chemoresistance Mechanisms in Pancreatic Cancer
Creators: name: Schober, Marvin
name: Jesenofsky, Ralf
name: Faissner, Ralf
name: Krug, Sebastian
name: Weidenauer, Cornelius
name: Hagmann, Wolfgang
name: Haas, Stephan L
name: Heuchel, Rainer L
name: Löhr, Matthias J
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Pancreatic Neoplasms

description: Context Pancreatic ductal adenocarcinoma is a dismal disease with one of the worst prognoses amongst solid tumors. Its ability to develop chemoresistance mechanisms towards cytotoxic drugs is the main cause of treatment failure. Objective Here, we have established a drug-resistance model for pancreatic cancer in which Capan-1 pancreatic carcinoma cells (designated Capan-1 5-FU2000) acquired 5-fluorouracil (5-FU) resistance and were used as a paradigm to reveal alterations in intracellular signaling cascades that. Those alterations may contribute to the circumvention of apoptosis during the course of the disease, culminating in treatment failure. Methods We made use of 2-D-gelelectrophoresis, mass-spectrometry, sandwich-ELISA and western blotting to compare the proteomic expression patterns of respective mediators involved in pro- and antiapoptotic as well as inflammatory processes in both cell lines. An ATP-based chemosensitivity assay validated the chemoresistant phenotype of the Capan-1 5-FU2000 clones. Results We detected specific changes in our resistant cell clones in particular a decreased expression of S100A4. We also found a decreased basal phosphorylation of SAPK/JNK and P38. The expression of the pro-apoptotic mediators Bok and Bad was down- and up-regulated in these cells, respectively. In case of NfkB p65 and IkB-alpha treatment with 5-FU (2,000 µg/mL for 96 h) markedly induced phosphorylation in native Capan-1 cells. In contrast in resistant clones it decreased phosphorylation of NfkB p65 and did not affect IkB-alpha phosphorylation. Basal phosphorylation of S6-ribosomal-protein was markedly increased in resistant clones, treatment with 5-FU decreased this phosphorylation, while in native Capan-1 cells it was vice versa. Conclusion Thus we can conclude that several pathways were found to be altered in chemoresistant Capan-1 5-FU2000 cells. Moreover these alterations are most likely the consequence of a multistep adaption towards gradual cytotoxic exposure finally culminating in a chemoresistant phenotype. Interfering with these pathways may possibly reverse the phenotype and thus open up alternative treatment options.

Image: Effect of 5-FU treatment on NfkB p65 phosphorylation in native and 5-FU resistant cells.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323
Personnes, chiffres, faits
Creators: name: Redaktion, Die
Publisher: name: Jahresbericht SIK-ISEA / Schweizerisches Institut für Kunstwissenschaft
Year: 2019

description: Jahresbericht SIK-ISEA / Schweizerisches Institut für Kunstwissenschaft, 2019: Jahresbericht 2018 SIK-ISEA
Ausstellungskalender
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Bd. 16 Nr. 12 (1963): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Intrinsic Stability: Global Stability of Dynamical Networks and Switched Systems Resilient to any Type of Time-Delays
Creators: name: Reber, David
name: Webb, Benjamin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 68T05, 90B10, 90B15

description: In real-world networks the interactions between network elements are inherently time-delayed. These time-delays can not only slow the network but can have a destabilizing effect on the network's dynamics leading to poor performance. The same is true in computational networks used for machine learning etc. where time-delays increase the network's memory but can degrade the network's ability to be trained. However, not all networks can be destabilized by time-delays. Previously, it has been shown that if a network or high-dimensional dynamical system is intrinsically stable, which is a stronger form of the standard notion of global stability, then it maintains its stability when constant time-delays are introduced into the system. Here we show that intrinsically stable systems, including intrinsically stable networks and a broad class of switched systems, i.e. systems whose mapping is time-dependent, remain stable in the presence of any type of time-varying time-delays whether these delays are periodic, stochastic, or otherwise. We apply these results to a number of well-studied systems to demonstrate that the notion of intrinsic stability is both computationally inexpensive, relative to other methods, and can be used to improve on some of the best known stability results. We also show that the asymptotic state of an intrinsically stable switched system is exponentially independent of the system's initial conditions.
description: 25 pages, 4 figures
Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF
Creators: name: Hupfeld, Enrico
name: Schlee, Sandra
name: Wurm, Jan Philip
name: Rajendran, Chitra
name: Yehorova, Dariia
name: Vos, Eva
name: Ravindra Raju, Dinesh
name: Kamerlin, Shina Caroline Lynn
name: Sprangers, Remco
name: Sterner, Reinhard
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: (βα)8-barrel, protein dynamics, loop motion, enzyme kinetics, enzyme mechanism, stopped-flow analysis, nuclear magnetic resonance spectroscopy, molecular dynamics simulation
subject: 540 Chemie

description: The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such motions can control different steps of catalysis. We have studied this problem on the example of the mobile active site β1α1-loop (loop1) of the (βα)8-barrel enzyme HisF, which is the cyclase subunit of imidazole glycerol phosphate synthase. Loop1 variants containing single mutations of conserved amino acids showed drastically reduced rates for the turnover of the substrates N′-[(5′-phosphoribulosyl) formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (PrFAR) and ammonia to the products imidazole glycerol phosphate (ImGP) and 5-aminoimidazole-4-carboxamide-ribotide (AICAR). A comprehensive mechanistic analysis including stopped-flow kinetics, X-ray crystallography, NMR spectroscopy, and molecular dynamics simulations detected three conformations of loop1 (open, detached, closed) whose populations differed between wild-type HisF and functionally affected loop1 variants. Transient stopped-flow kinetic experiments demonstrated that wt-HisF binds PrFAR by an induced-fit mechanism whereas catalytically impaired loop1 variants bind PrFAR by a simple two-state mechanism. Our findings suggest that PrFAR-induced formation of the closed conformation of loop1 brings active site residues in a productive orientation for chemical turnover, which we show to be the rate-limiting step of HisF catalysis. After the cyclase reaction, the closed loop conformation is destabilized, which favors the formation of detached and open conformations and hence facilitates the release of the products ImGP and AICAR. Our data demonstrate how different conformations of active site loops contribute to different catalytic steps, a finding that is presumably of broad relevance for the reaction mechanisms of (βα)8-barrel enzymes and beyond.
Data-driven quasi-interpolant spline surfaces for point cloud approximation
Creators: name: Raffo, Andrea
name: Biasotti, Silvia
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: Graphics (cs.GR)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: G.1.2; G.3; I.3.5
subject: 41A15, 62G08 (Primary) 62P12 (Secondary)

description: In this paper we investigate a local surface approximation, the Weighted Quasi Interpolant Spline Approximation (wQISA), specifically designed for large and noisy point clouds. We briefly describe the properties of the wQISA representation and introduce a novel data-driven implementation, which combines prediction capability and complexity efficiency. We provide an extended comparative analysis with other continuous approximations on real data, including different types of surfaces and levels of noise, such as 3D models, terrain data and digital environmental data.
Outcome of Laparoscopic Surgery in Patients with Cystic Lesions in the Distal Pancreas
Creators: name: Ånonsen, Kim V
name: Buanes, Trond
name: Røsok, Bård Ingvald
name: Hauge, Truls
name: Edwin, Bjørn
Publisher: name: JOP. Journal of the Pancreas
Year: 2015
Subjects: Pancreas

description: Context Recent guidelines for the management of cystic lesions of the pancreas recommend observation for selected neoplasms using imaging criteria. However, current imaging modalities lack diagnostic accuracy, and the indication for surgery is debated. Objective In this study we have explored the outcome of laparoscopic distal pancreatic resections in all patients referred with potential pancreatic cystic neoplasms, with histological diagnosis as endpoint. Methods Between 1997 and 2009 all patients referred to our tertiary referral centre having a cystic neoplasm of the distal pancreas accepted for surgery were included in the present observational study. Results A total of 69 patients were included. Sixty-two patients underwent distal pancreatectomies, in whom 19 were spleen-preserving, and 7 enucleations were performed. Two procedures were converted to open technique. The lesions removed in 27 patients (39%) were either malignant or premalignant. The final diagnoses were serous cystic neoplasm (n=29), mucinous cystic neoplasm (n=12), pseudocyst (n=11), solid pseudopapillary neoplasm (n=10), intraductal papillary mucinous neoplasm (n=5) and other (n=2). Overall morbidity was 33%; 56% of the complications were classified as mild. Fistula rate was 10%. One patient died postoperatively from a cerebral haemorrhage. Conclusion Most complications after laparoscopic distal resection of cystic pancreatic lesions are mild, but the proportion of patients with benign lesions (61%) has to be reduced by focused preoperative investigations. Endoscopic ultrasound examination (EUS), enabling aspiration of cyst fluid and fine needle aspiration is an additional option for the preoperative workup.

Image: Histological diagnosis of the resected specimens.
description: JOP. Journal of the Pancreas, Vol 16, No 3 (2015): May - p. 218-323