cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hypoglycemic and hepatoprotective effects in adult zebrafish (Danio rerio) of fisetinidol isolated from Bauhinia pentandra: In vivo and in silico assays
Creators: name: da Silva, Horlando Carlota
name: de Oliveira Monteiro, Aurelio
name: de Queiroz Almeida-Neto, Francisco Wagner
name: Marinho, Emanuelle Machado
name: Ferreira, Maria Kueirislene Amâncio
name: da Silva Mendes, Francisco Rogênio
name: Marinho, Emmanuel Silva
name: Marinho, Márcia Machado
name: Bezerra, Lucas Lima
name: da Rocha, Matheus Nunes
name: de Menezes, Jane Eire Silva Alencar
name: Teixeira, Alexandre Magno Rodrigues
name: da Silva, Antonio Wlisses
name: de Lima Rebouças, Emanuela
name: Pinto, Francisco das Chagas Lima
name: Santos, Hélcio Silva dos
name: Santiago, Gilvandete Maria Pinheiro
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Diabetes mellitus is a chronic metabolic disorder that has been increasing drastically around the worldwide. It is important to emphasize that although many drugs are commercially available to treat diabetes, many of them have shown a number of adverse effects. Therefore, search for new antidiabetic agents is of great interest, and natural products, especially those obtained from plants sources, may be an alternative to available drugs. This study reports the in vivo and in silico evaluation of the hypoglycemic activity of fisetinidol. The conformational analysis confirmed that the fisetinidol compound possesses two valleys in the potential energy curve, showing a stable conformer on the global minimum of the PES defined by the dihedral angle θ (C6-C7-O-H) at 179.9°, whose energy is equal to zero. In addition, fisetinidol has shown promise in glycemic control and oxidative stress caused by hyperglycemia induced by high sucrose concentration, causing hypoglycemic and hepatoprotective effects in adult zebrafish. ADMET studies showed that fisetinidol has high passive permeability, low clearance and low toxic risk by ingestion, and computational studies demonstrated that fisetinidol complexes in the same region as metformin and α-acarbose, which constitutes a strong indication that fisetinidol has the same inhibitory mechanisms of α-acarbose and metformin. Communicated by Ramaswamy H. Sarma.
Gynaephora selenitica
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Gynaephora
Gynaephora selenitica

description: Gynaephora selenitica (Esper, 1789)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, с. КойΔа, забоΛоченные тунΔры, 66 ° 23'27"N, 42 ° 28'33"E, 04.06.2020, E. Spitsyna & V. Spitsyn leg. — 1 экз. (гусеница).
 Примечание. Первая нахоΔка ΔΛя фауны АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
À Dresden en Saxe
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1787
Subjects: Dresden

description: Blick auf die Augustusbrücke in Dresden. Die Staffage zeigt auf der Elbe zwei Boote
description: des. d'ap. n. ... p[a]r J.C. E[scher] de K[efikon]
About MathPartner web service
Creators: name: Malaschonok, Gennadi
name: Borisov, Ivan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Symbolic Computation (cs.SC)
subject: FOS: Computer and information sciences
subject: I.1.4
subject: 68W30

description: The report is devoted to the current state of the MathPartner computer algebra web project. We discuss the main directions of development of the project and give several examples of using it to solve selected problems.
description: 5 pages
[Ansichtsskizze]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: [Hans Conrad Escher von der Linth]
description: Beschriftung im Bild: "Ballaruc". Wahrscheinlich handelt es sich um den Ort Balaruc-les-Bains in Südfrankreich. Vgl. Gustav Solar: Der persönliche Lebensbericht von Hans Conrad Escher von der Linth, Erster Teil, Mollis 1998, S. 391
Diacrisia sannio
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Diacrisia
Diacrisia sannio

description: Diacrisia sannio (Linnaeus, 1758)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, оз. КойΔа, верховое боΛото, 65 ° 57'16"N, 42 ° 26'17"E, 03.07.2022, E. Spitsyna & V. Spitsyn leg. — 1♂, 1♀.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 264, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Scrapter fuscipennis
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter fuscipennis

description: Scrapter fuscipennis (FRIESE, 1912)spec. rev.
 Strandiella fuscipennis FRIESE, 1912: 183. Lectotype ♀ [designated by EARDLEY 1996] (Kapland, South Africa) (ZMHB), examined.
 EARDLEY (1996) synonymised this species with S. nitidus (FRIESE).
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 701, DOI: 10.5281/zenodo.13154583
Deciphering the molecular mechanisms of selective non-covalency demonstrated differentially by 9-Allylnaphtho[1,8-ef]isoindole-7,8,10(9H)-trione (C11) against fibroblast growth factor receptors 1–4
Creators: name: Olotu, Fisayo A.
name: Soliman, Mahmoud E. S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Medicine
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Computational Biology

description: The specific inhibition of aberrant Fibroblast Growth Factor Receptors (FGFRs) has been identified as a feasible strategy to therapeutically ameliorate their respective carcinogenic involvements. High homology among these proteins has however limited efforts towards the discovery of selective small-molecule compounds due to undesirable effects elicited by pan-FGFR inhibitors. A recent study showed the selective activity of a new compound C11 which was >52 times more potent against FGFR1 than FGFR2 and FGFR3, and 4 times than FGFR4. This C11 selective non-covalency was investigated in this study using computational methods since it has remained unresolved. Structural findings revealed that C11 enhanced structural perturbations in FGFR1 with less prominent effects in other FGFRs. High deviations also characterized the C11-bound active pocket of FGFR1 with notable fluctuations across the constituent P-loop, αC helix, hinge region, catalytic, and activation loops. These induced motions were essential for optimal C11 motion an d positioning of its phenalenone ring and prop-2-en-l-yl moiety at the FGFR1 active pocket to interact stably and strongly with A564FGFR1, L484FGFR1, Y563FGFR1, and E562FGFR1 which as well had high energy contributions. C11 exhibited highly unstable binding in F GFRs2-3 with a more steady interaction with FGFR4. Free binding energy (ΔGbind) analyses further estimated the highest interaction energy for C11-FGFR1 with favorable desolvation energy that indicated a deep hydrophobic pocket binding for C11 in FGFR1 compared to other FGFRs. We believe rational insights from this study will contribute to the structure-based design of highly specific FGFR1 inhibitors. Communicated by Ramaswamy H. Sarma Figures showing the binding variations of 9-Allylnaphtho[1,8-ef]isoindole-7,8,10(9 H)-trione (C11) at the catalytic pockets of FGFRs1-4.
An der Donau unter Straubingen
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788
Subjects: Bogenberg, Bogen, Straubing-Bogen

description: Blick auf die Donau unterhalb von Straubing. Die Staffage, ein Flussboot und ein Mann mit Hund am Ufer, sind nur angedeutet. Bei der Kirche in der Bildmitte handelt es sich möglicherweise um die Wallfahrtskirche Bogenberg
description: des. d'a. nat. p. Escher
description: Beschriftung im Bild: "mont. éloignées avec qque neiges"
À Passau sur le Danube
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: des. d'ap. nat. ... p. J.C. Escher
description: Beschriftungen im Bild: "sapins hau[-]tes avec quque arbres à feuile", "beau verd"
Anarta melanopa
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Anarta
Anarta melanopa

description: Anarta melanopa (Thunberg, 1791)
 Рис. 1: D
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, с. КойΔа, забоΛоченные тунΔры, 66 ° 23'23"N, 042 ° 28'25"E, 07 — 19.06.2020, E. Spitsyna & V. Spitsyn leg. — 1♂.
 Примечание. Первая нахоΔка ΔΛя фауны АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 264, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Elucidating the inhibitory mechanism of yeast α-glucosidase by phytocompounds from Scoparia dulcis through in vitro and in silico approach
Creators: name: Murugan, Gopinath
name: Rajkumar, Divya Sangeetha
name: Kaliyaperumal, Malarvizhi
name: Ramdoss, Ramya
name: Natarajan, Sasirekha
name: Padmanaban, Rajashree
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Antidiabetic activity of herb Scoparia dulcis Linn (SD) used in traditional medicine is well established, yet, the molecular mechanism is not understood. In this study, in vitro α-glucosidase inhibitory effects of SD aqueous extract and its kinetics were investigated and in silico analysis was carried out. SD showed potent inhibition of α-glucosidase with low IC50value (30 μg/mL). Enzyme kinetics analysis revealed the inhibition to be a mixed type of inhibition. From literature screening, we found that six compounds of SD to exhibit potent anti-diabetic activity, namely apigenin, betulinic acid, hispidulin, luteolin, scopadulcic-acid-B and scutellarein. These compounds were subjected to molecular docking. Docking studies revealed scopadulcic acid B and betulunic acid to show optimum binding constant and low free energy. Molecular dynamics simulation was carried out to further understand the interaction and stability between glucosidase and ligands of SD. Taken together, the study reveals that the potency of SD is due to synergistic effect of active phytochemicals in it and suggest that their properties can be utilized for anti-diabetic treatment strategies. Communicated by Ramaswamy H. Sarma
Vom Kalenberg bey Wien, gegen die ungarische Gränze
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: Aussicht vom Kahlenberg bei Wien. Die Staffage zeigt einen Reiter mit Pferd
description: n. d. Nat. gez. v. J.C. Escher
Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors
Creators: name: Rathi, Aditya
name: Kumar, Vipul
name: Sundar, Durai
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Medicinal herbs have been used as traditional medicines for centuries. The molecular mechanism of action of their bioactive molecules against various diseases or therapeutic targets is still being explored. Here, the active compounds (withanolides) of a well-known Indian medicinal herb, Ashwagandha (Withania somnifera), have been studied for their most potential therapeutic targets and their mechanism of action using ligand-based screening and receptor-based approaches. Ligand-based screening predicted the six top therapeutic targets, namely, Protein kinase C alpha (PRKCA), Protein kinase C delta (PRKCD), Protein kinase C epsilon (PRKCE), Androgenic Receptor (AR), Cycloxygenase-2 (PTGS-2) and Phosphodiesterase-4D (PDE4D). Further, when these predictions were validated using receptor-based studies, i.e. molecular docking, molecular dynamics simulation and free energy calculations, it was found that PDE4D was the most potent target for four withanolides, namely, Withaferin-A, 17-Hydroxywithaferin-A, 27-Hydroxywithanone and Withanolide-R. These compounds had a better binding affinity and similar interactions as that of an already known inhibitor (Zardaverine) of PDE4D. These results warrant further in-vitro and in-vivo investigations to examine their therapeutic potential as an inhibitor of PDE4D. Communicated by Ramaswamy H. Sarma
Bey Lerici an der östlichen Küste von Genua
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: Blick auf die Küste mit der Burg von Lerici. Die Staffage zeigt einen Flöten spielenden Hirten mit zwei Hirtenhunden und einer Ziege
description: n. d. Nat. gezcht v H. Cd. Escher
In-silico investigation of some recent natural compounds for their potential use against SARS-CoV-2: a DFT, molecular docking and molecular dynamics study
Creators: name: Erdogan, Taner
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Medicine
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Since its first appearance in December 2019, SARS-CoV-2 has infected many people all over the world, causing serious health problems in many people and causing many deaths, but no specific drug has been developed yet. SARS-CoV-2 main protease (SARS-CoV-2 Mpro) has an important role in viral replication and transcription, so inhibition of this enzyme is proposed to be an attractive route for the treatment of COVID-19. Natural compounds have been used in the treatment of many diseases throughout the history. In this study, it was aimed to investigate SARS-CoV-2 Mpro inhibition abilities, thus the therapeutic potentials of some novel phytochemicals which have recently been entered the literature. For this purpose, eleven novel phytochemicals obtained from various natural resources have been investigated for their potential antiviral activity against SARS-CoV-2 with the use of in silico methods. In the first part of the study, DFT (density functional theory) calculations were performed on the investigated compounds. In this part, geometry optimizations, vibrational analyses, and MEP (molecular electrostatic potential) map calculations were performed. In the second part, molecular docking calculations and then molecular dynamics (MD) simulations were performed to investigate how these natural compounds interact with SARS-CoV-2 Mpro which is a promising target for COVID-19 treatments. In this part, MM-PBSA (molecular mechanics with Poisson-Boltzmann surface area) calculations were also performed to determine the binding free energies of the investigated compounds. Results showed that most of the investigated compounds interacted with SARS-CoV-2 Mpro effectively and can be promising structures for drug development studies for COVID-19. Communicated by Ramaswamy H. Sarma
[Posillipo]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: Blick auf die Hügel des Posillipo und die Bucht von Pozzuoli bei Sonnenuntergang
description: [Hans Conrad Escher von der Linth]
description: Wahrscheinlich handelt es sich um die Zeichnung, die Escher am Abend des 10. Juni 1788 gemacht hat. Vgl. Gustav Solar: Der persönliche Lebensbericht von Hans Conrad Escher von der Linth, Erster Teil, Mollis 1998, S. 334
Coranarta cordigera
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Coranarta
Coranarta cordigera

description: Coranarta cordigera (Thunberg, 1788)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, забоΛоченная тунΔра с реΔкими соснами, 66 ° 07'59"N, 42 ° 42'12"E, 16.06.2022, E. Spitsyna & V. Spitsyn leg. — 1♀.
 Примечание. Третья нахоΔка виΔа в АрхангеΛьской обΛасти, первая нахоΔка ΔΛя Мезенского района.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 265, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Le  Cusine
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788
Subjects: Landhaus

description: [Hans Conrad Escher von der Linth]
description: Wahrscheinlich handelt es sich um das Landgut der Familie Roman in der Nähe von Genf. Escher berichtet, er habe bei der Familie Roman "bald in der Stadt, bald auf ihrem ländlichen Gut «à la cuisine»" gewohnt (Gustav Solar: Der persönliche Lebensbericht von Hans Conrad Escher von der Linth, Erster Teil, Mollis 1998, S. 394)
Three Lectures of Flavor and CP Violation within and Beyond the Standard Model
Creators: name: Gori, Stefania
Publisher: name: CERN
Year: 2017
Subjects: Flavor; CP violation; standard model.

description: These notes are based on the lectures I gave at the 2015 European School of High-Energy Physics (ESHEP2015). I discuss 1) flavor physics within the Standard Model, 2) effective field theories and Minimal Flavor Violation, 3) flavor physics in theories beyond the Standard Model and “high energy" flavor transitions of the top quark and of the Higgs boson. As a bi-product, I present the most updated constraints from the measurements of Bs → μ+μ-, as well as I discuss the most recent development in the LHC searches for top flavor changing couplings.
description: CERN Yellow Reports: School Proceedings, Vol 4 (2017): Proceedings of the 2015 European School of High-Energy Physics
Designing of nanobodies against Dengue virus Capsid: a computational affinity maturation approach
Creators: name: Chaudhuri, Dwaipayan
name: Majumder, Satyabrata
name: Datta, Joyeeta
name: Giri, Kalyan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dengue virus, an arbovirus, is one of the most prevalent diseases in the tropical environment and leads to huge number of casualties every year. No therapeutics are available till date against the viral disease and the only medications provide symptomatic relief. In this study, we have focused on utilizing conventional nanobodies and repurposing them for Dengue. Computationally affinity matured, best binding nanobodies tagged with constant antibody regions, could be proposed as therapeutics. These could also be applied for drug delivery purposes due to their high specificity against the viral Capsid. Another application of these nanobodies has been thought to utilize them for diagnostic purposes, to use the nanobodies for viral detection from patient samples at the earliest stage using ELISA. This study may open a new avenue for immunologic study in foreseeable future with the usage of the same molecules for multiple purposes.
HighlightsNatural nanobodies against viruses were modified for use against Dengue virus Capsid conserved regions.Computational affinity maturation was performed making use of change in binding affinities upon mutating various residues in the complementary determining regions.Docking studies performed to inspect the docking groove, interface analysis and energy calculations.MM/GBSA calculations done to calculate binding free energy of the complex to determine stability of the complex. Natural nanobodies against viruses were modified for use against Dengue virus Capsid conserved regions. Computational affinity maturation was performed making use of change in binding affinities upon mutating various residues in the complementary determining regions. Docking studies performed to inspect the docking groove, interface analysis and energy calculations. MM/GBSA calculations done to calculate binding free energy of the complex to determine stability of the complex. Communicated by Ramaswamy H. Sarma
[Trigonometrischer Orientierungsversuch von Schloss Kefikon]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788
Subjects: Gachnang

description: J.C. E[scher]
description: Es handelt sich um die Darstellung der Winkel, unter welchen markante Punkte des Panoramas von Kefikon aus gesehen werden. Der Standort wird mit "vom Schloss Keffiken" angegeben. Die anvisierten Punkte sind: "Neuforner Hochwach", "nach Eliken", "Häuser auf Iselisberg", "Hochwach auf Iselisberg", "nach dem Schloss Steinegg", "Hochwach auf Steinegg" und "nach dem Schloss Frauenfeld"
title: Study of the Influence of a Delayed Yielding Phenomenon in Magnetorheological Damping Devices on the Vibration Attenuation of a Jeffcott Rotor
Creators: name: Zapomel, J.
name: P. Ferfecki
Publisher: name: Otto von Guericke University Library, Magdeburg, Germany
Year: 2017

description: Technische Mechanik; 37; 2-5; 377-383; ISSN 2199-9244
description: A frequently used technological solution for attenuation of lateral oscillations of rotating machines consists in inserting damping devices between the rotor and its stationary part. To achieve their optimum performance, their damping effect must be controllable. This is enabled by magnetorheological squeeze film dampers. As resistance against the flow of magnetorheological liquids depends on magnetic induction, the change of magnetic flux passing through the lubricating film enables to control the damping effect. The developed mathematical model of a magnetorheological squeeze film damper is based on assumptions of the classical theory of lubrication. The oil is represented by bilinear material. The pressure distribution in the damper gap is described by the modified Reynolds equation. The dependence of the stationary value of the yielding shear stress on magnetic induction is approximated by a power function. Its dependence on time is governed by a convolution integral, which enables to take into account that the yielding shear stress depends not only on the instant value of magnetic induction but also on its history in the past. In cavitated regions it is considered that the yielding shear stress drops to zero. The developed mathematical model of the damper was implemented in the computational procedures for analysis of lateral vibrations of a flexibly supported Jeffcott rotor loaded by the disc unbalance. The carried out simulations showed that the rising value of the delayed yielding time constant reduces the damping effect. The development of a novel model of a magnetorheological squeeze film damper based on representing the lubricating oil by bilinear material taking into account the delayed yielding phenomenon, its implementation into the procedures for analysis of oscillations of rotating machines, increasing their computational stability, and learning more on the effect of magnetorheological damping devices on behaviour of flexible rotors are the principal contributions of this article.
Elucidating the inhibitory mechanism of yeast α-glucosidase by phytocompounds from Scoparia dulcis through in vitro and in silico approach
Creators: name: Murugan, Gopinath
name: Rajkumar, Divya Sangeetha
name: Kaliyaperumal, Malarvizhi
name: Ramdoss, Ramya
name: Natarajan, Sasirekha
name: Padmanaban, Rajashree
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Antidiabetic activity of herb Scoparia dulcis Linn (SD) used in traditional medicine is well established, yet, the molecular mechanism is not understood. In this study, in vitro α-glucosidase inhibitory effects of SD aqueous extract and its kinetics were investigated and in silico analysis was carried out. SD showed potent inhibition of α-glucosidase with low IC50value (30 μg/mL). Enzyme kinetics analysis revealed the inhibition to be a mixed type of inhibition. From literature screening, we found that six compounds of SD to exhibit potent anti-diabetic activity, namely apigenin, betulinic acid, hispidulin, luteolin, scopadulcic-acid-B and scutellarein. These compounds were subjected to molecular docking. Docking studies revealed scopadulcic acid B and betulunic acid to show optimum binding constant and low free energy. Molecular dynamics simulation was carried out to further understand the interaction and stability between glucosidase and ligands of SD. Taken together, the study reveals that the potency of SD is due to synergistic effect of active phytochemicals in it and suggest that their properties can be utilized for anti-diabetic treatment strategies. Communicated by Ramaswamy H. Sarma
WhoLoDancE: Deliverable 1.5 - Data acquisition plan
Creators: name: El Raheb, Katerina
name: Katifori, Vivi
name: Kasomoulis, Aristotelis
Publisher: name: Zenodo
Year: 2016
Subjects: data acquisition
plan
methodology

description: The following deliverable presents the methodology which was followed in order to plan the Motion Capture Sessions of WhoLoDancE, in a way that will maximize the impact of the technologies used, optimize the time management, select the movement sequences that we need to capture and store, and prepare for these sessions aiming at building a repository of movement which will cover the needs of the learning scenarios of WhoLoDancE. This deliverable according to the project time-plan has a delivery date later than the conclusion of the motion capture sessions as foreseen from the same time-plan. The deliverable reports both the data acquisition plan as it has been formulated before the realization of the sessions and also gives an overview of the results of the process. Sections 2 and 3 outline the planning process and provide details on how it has been realized whereas section 4 presents a summary of the outcomes, both in terms of content produced and infrastructure used for its storage. In particular, in section 2 (Methodology and Preparation), we describe the steps which we have followed to organize the collaboration between technical and dance partners and deal with the variety and diversity of the four different dance genres/use cases of WhoLoDancE (Contemporary dance, Ballet, Greek Folk, Flamenco). We explain the systematic way of preparing the shot list, aiming at keeping the balance between a) user-oriented and context-specific perspective, in order to select kinetic content which will be satisfying to deliver the needs of each dance genre learning scenario, and b) technical perspective, through selecting data which will be subject to further automated analysis, and synthesis of movements and will support the different objectives of the WhoLoDancE project. In section 4 (The process: Motion Capture Sessions), we describe the process of the Motion Capture sessions, including a short description of the technologies used, the locations, the context of capturing and quality control. The third and last part summarizes the outcome of the Motion Capture sessions and provides numbers and statistics about the produced data. Finally, at the end (section 5) there is an appendix with the detailed schedules and other relevant documents.
Das  Katzenthörchen
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788
Subjects: Zürich

description: Die Zeichnung zeigt das Katzentörchen, auch Ketzistörchen oder Wollishofer Thörlein genannt, das 1815 abgerissen wurde
description: [Hans Conrad Escher von der Linth]
H2020 692819 Simpatico - D5.2: Simpatico Platform Requirements And Architecture V2
Creators: name: Filograna Antonio
Publisher: name: Zenodo
Year: 2017
Subjects: architecture, requirements, use case, sequence diagram

description: This document corresponds to deliverable “D5.2 – SIMPATICO platform requirements and architecture v2” of the European H2020 project “SIMPATICO – SIMplifying the interaction with Public Administration Through Information technology for Citizens and cOmpanies” (hereinafter also referred to as “SIMPATICO”, project reference 692819).

This report includes the results of project task T5.1 “Technical specification and architecture of the SIMPATICO platform”. The aim of this document is to give an overview on the SIMPATICO architecture, describing its requirements and the different components that build it. This document is an update of deliverable D5.1, which has been produced in the initial phases of the project; the updates take into account the outcomes of the first round of software development, integration, deployment and validation executed in the project.

The SIMPATICO component requirements have been collected taking into account the feedback coming from the first phase of experimentation given both by technical team of each use case and citizens.

The SIMPATICO architecture has been re-designed in order to meet the new component requirements.

All the SIMPATICO technical components have been described highlighting their input and output in order to allow the interaction among all the other SIMPATICO components.

Also the component cards have been updated taking into account the new requirements.
Additional file 1 of Comparative transcriptomics identifies genes underlying growth performance of the Pacific black-lipped pearl oyster Pinctada margaritifera
Creators: name: Dorant, Y.
name: Quillien, V.
name: Le Luyer, J.
name: Ky, C. L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
[Hügellandschaft]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1788

description: [Hans Conrad Escher von der Linth]
description: Notiz auf dem Verso: "Straf. leer bout. (?) Gratulat. Ausstand. Unterbrechung. Kein Ausstand. Seezet"
description: Titel nach Brandenberger übernommen
Diploptera maculata Hanitsch 1925, syn. nov.
Creators: name: Wang, Zong-Qing
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Blattodea
Blaberidae
Diploptera
Diploptera maculata

description: Diploptera maculata Hanitsch
Diploptera bicolor Hanitsch syn. nov.
Diploptera pulchra Anisyutkin syn. nov.
Diploptera maculata and D. bicolor are known for females only and males only, respectively. Molecular data in the present study prove that they represent the two sexes of one species. No priority between them because they were published in one paper. We considered that the epithet maculata better describes the diagnostic characters of this species, therefore D. maculata is regarded as the senior synonym of D. bicolor. Diploptera pulchra is a synonym of D. bicolor, and is a new synonym of D. maculata. Therefore, D. maculata is the only known sexually dimorphic species in Diploptera (Fig. 5).
description: Published as part of Wang, Zong-Qing, 2017, Preliminary molecular phylogeny of beetle cockroaches (Diploptera) and notes on male and female genitalia (Blattodea: Blaberidae: Diplopterinae), pp. 523-534 in Zootaxa 4320 (3) on page 529, DOI: 10.11646/zootaxa.4320.3.7, http://zenodo.org/record/893814
Cientificacvn: Nuevo Sistema De Información Científica De La Universidad De Navarra
Creators: name: Torres-Salinas, Daniel
Publisher: name: Zenodo
Year: 2013
Subjects: Sistemas de información
CRIS
Bases de datos
Evaluacion de la ciencia
Información científica
Bibliometría
Currículum Vitae Normalizado (CVN)
Universidad de Navarra
Científicacvn

description: El objetivo general de la presentación Introducir a los miembros de la comunidad universitaria de la UNAV al nuevo sistema de información científica "Científicacvn". Contenidos básicos de la presentación; 1. Características generales, 2. Un paseo por Científicacvn.
description: Nota : 	Ponencia en las sesiones de presentación, Universidad de Navarra 25 y 26 de Marzo de 2013.

Referencia bibliografica : 	Torres-Salinas, D. Cientificacvn: nuevo sistema de información científica de la Universidad de Navarra. En: Sesión de presentación en la Universidad de Navarra, 25 y 26 de Marzo de 2013.
In vitro cytotoxicity, antibacterial activity and HSA and ct-DNA interaction studies of chlorogenic acid loaded on γ-Fe2O3@SiO2 as new nanoparticles
Creators: name: Shahabadi, Nahid
name: Akbari, Alireza
name: Karampour, Fatemeh
name: Falsafi, Monireh
name: Zendehcheshm, Saba
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Physical Sciences not elsewhere classified
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: In this study, nanoparticles with both anticancer and antibacterial features were synthesized through loading chlorogenic acid (CGA) of essential oils on magnetic nanoparticles (MNPs). Characterization of γ-Fe2O3@SiO2-CGA MNPs was performed using Fourier transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM) that show effective coating of the MNPs with SiO2 and CGA ligand and spherical shape of the nanoparticles with a mean diameter of 16 nm, respectively. The cytotoxicity study demonstrated that γ-Fe2O3@SiO2-CGA MNPs had fewer toxic effects on normal cells (Huvec) than on cancerous cells (U-87 MG, A-2780 and A-549), and could be a new potential candidate for use in biological and pharmaceutical applications. The interaction of calf thymus deoxyribonucleic acid (ct-DNA) with γ-Fe2O3@SiO2-CGA MNPs indicated that the anticancer activity might be associated with the DNA binding properties of γ-Fe2O3@SiO2-CGA MNPs. Moreover, the interaction of γ-Fe2O3@SiO2-CGA MNPs with human serum albumin (HSA) suggests that the native conformation of HSA was preserved at the level of secondary structure, indicating that the γ-Fe2O3@SiO2-CGA MNPs do not show any cytotoxicity effect when they are injected into the blood. Antibacterial tests were performed and represented γ-Fe2O3@SiO2-CGA MNPs attained better antibacterial function than CGA as free.
Diploptera punctata
Creators: name: Wang, Zong-Qing
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Blattodea
Blaberidae
Diploptera
Diploptera punctata

description: Diploptera punctata and D. minor
Diploptera punctata is said to be a widespread species, but it is doubtful whether all recorded specimens are genuine D. punctata. As an example, D. cf. punctata in the present study has large genetic divergence from determined D. punctata, and the differences in female genitalia are observable (see above). Re-examinations of the specimens recorded as D. punctata are needed. Although cross experiments are recommended, male genitalia morphology and molecular phylogeny should be more economical. To date, based on Lenkic et al. (2008) and the present study, only those from Hawaii and continental Asia can be reliably identified as D. punctata. Diploptera minor is very similar to D. punctata. It differs from the latter only by the tawny legs and the anterior arch of female genitalia (see above). We are not sure that these differences can discriminate between species; the phylogeny also provides us with two interpretations: 1) these two nominal species are separate groups in nature, or 2) D. minor represents a certain founder population of D. punctata, e.g. Luzon in the present study.
Updates to species distribution. According to Leonardo Fea’s travel map (Maria Tavano, personal communication) and his travel notes (Fea 1896), the localities of D. punctata are revised (Fig. 6). This mainly concerns ‘Catcin Cauri’, an area lying on the China-Burmese border to the east of Bhamo, Burma. In the present day, most of this area may correspond to Longchuan, Yunnan, China. A D. elliptica specimen from the same locality, collected by Fea, deposited in MHNG, was rediscovered (Dr. Peter J. Schwendinger, personal communication). Distributional data of other species are also updated based on our new materials (Fig. 6).
description: Published as part of Wang, Zong-Qing, 2017, Preliminary molecular phylogeny of beetle cockroaches (Diploptera) and notes on male and female genitalia (Blattodea: Blaberidae: Diplopterinae), pp. 523-534 in Zootaxa 4320 (3) on pages 529-530, DOI: 10.11646/zootaxa.4320.3.7, http://zenodo.org/record/893814
Deciphering the role of aquaporin 1 in the adaptation of the stinging catfish Heteropneustes fossilis to environmental hypertonicity by molecular dynamics simulation studies
Creators: name: Chutia, Priyambada
name: Das, Manas
name: Goswami, Nabajyoti
name: Choudhury, Manisha
name: Saha, Nirmalendu
name: Sarma, Kishore
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Computational Biology

description: A thorough investigation of the water permeability of H. fossilis aquaporin 1 (hfAQP1) in a hypertonic environment can provide a useful insight into the understanding of the underlying molecular mechanism of its high tolerance to salinity. Here, we constructed a 3 D homology model of hfAQP1 by taking Bos taurus AQP1, AQP0, and human AQP2 as templates using I-TASSER. The model obtained has similar structural organizations with mammalian AQP1s in all aspects. We investigated the water permeability of the modeled hfAQP1 in a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane under neutral and 100 mM hypersalinity by subjecting each system to a 100 ns molecular dynamics simulation. Our results show that hypersalinity hinders water permeation across the membrane through the hfAQP1 channel. A change in the intermolecular distance between key residues of the ar/R selectivity filter along with charge redistribution resulted in the accommodation of only 2–6 water molecules inside the channel at once under hypersaline conditions. We investigated the mRNA expression pattern of hfaqp1 in osmoregulatory organs of H. fossilis in response to 100 mM hypertonicity by using qPCR analysis. The transcript was downregulated in kidney and GI tract, but upregulated in the Gills. Thus, the catfish survive in a hypertonic environment by reducing the transport of water in its cellular systems and downregulating the expression of the hfaqp1 gene. The results observed in our study can shed more light on the functionality of AQP1 in catfishes under salinity stress and aid in future researches on solving more gating mechanisms involved in its regulation. Communicated by Ramaswamy H. Sarma
Münchenstein ds. le Cton. de Bâle
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1792
Subjects: Koalitionskriege
Münchenstein

description: Blick auf die Burg Münchenstein und die Birs. Die Staffage zeigt drei bewaffnete Soldaten in der Nähe eines Grenzsteines
description: des. d. n. ... p. J.C. Escher
Scrapter glaberrimus
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter glaberrimus

description: Scrapter glaberrimus (FRIESE, 1912)spec. rev.
 Strandiella glaberrima FRIESE, 1912: 183. Lectotype ♁ [designated by EARDLEY 1996] (Port Nolloth, South Africa) (SAMC), examined.
 EARDLEY (1996) synonymised this species with S. opacus (FRIESE). He designated a lectotype male of Strandiella glaberrima and gave the label data as ʻPt. Nolloth, aug. 90, R.M.L., Strandiella glaberrima Fr. ♁, 1910 Friese det., Typusʽ (EARDLEY 1996: 48). However, the specimen is not in ZMHB as mentioned by EARDLEY (1996) but in SAMC and is (probably erroneously) labelled as paralectotype because no paralectotype was mentioned in the publication.
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 701, DOI: 10.5281/zenodo.13154583
[Augustusbogen in Aosta]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1797

description: [Hans Conrad Escher von der Linth]
description: Beschriftungen im Bild: "Römisch", "ist zu eng", "Cité d'Aosta"
description: Datierung aufgrund des Lebensberichts: Gustav Solar: Der persönliche Lebensbericht von Hans Conrad Escher von der Linth, Zweiter Teil, Mollis 1998, S. 652
[Panorama der Pilatuskette]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1799

description: Ansichtsskizze von der Pilatuskette mit den Pilatus und dem Mittaggüpfi (Bildmitte), wahrscheinlich vom Dietschiberg aus gesehen
description: [gezeichnet von Hans Conrad Escher von der Linth]
description: Beschriftung im Bild: "Pilatus"
Scrapter nitidus
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter nitidus

description: Scrapter nitidus (FRIESE, 1909)
 Polyglossa nitida FRIESE, 1909: 125. Holotype ♁ (Steinkopf, South Africa) (ZMHB), examined. Polyglossa opaca FRIESE, 1909: 125. Holotype ♁ (Steinkopf, South Africa) (ZMHB), examined.
 Syn. nov.
 Examination of type specimens revealed that S. nitidus and S. opacus are synonyms and that the former type specimen is just an unusually small individual. Both males were collected in Steinkopf by Schultze and were described by Friese in the same publication and on the same page (FRIESE, 1909: 125). Following the Principle of the First Reviser I decided to give the name S. nitidus priority because the species-group has been named after this species and should be preserved.
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 702, DOI: 10.5281/zenodo.13154583
L' Ingenieur à la Linth
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1803
Subjects: Selbstbildnis
Ingenieur
Escher von der Linth, Hans Konrad1767-1823

description: Die Zeichnung zeigt wahrscheinlich Escher selbst, auf den Schultern eines Mitarbeiters sitzend
description: [Hans Conrad Escher von der Linth]
Scrapter sphecodoides
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter sphecodoides

description: Scrapter sphecodoides (FRIESE, 1912)spec. rev.
 Strandiella sphecodoides FRIESE, 1912: 183-184, fig. 3. Lectotype ♀ (Kapstadt, South Africa) [designated by EARDLEY 1996] (SAMC), examined.
 EARDLEY (1996) synonymised this species with S. nitidus (FRIESE).
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 702, DOI: 10.5281/zenodo.13154583
[Alplandschaft mit Bergsee]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1782
Subjects: Tiba
Bergsee

description: Blick auf einen Bergsee. Die Staffage zeigt zwei Personen in einem Ruderboot, einen Wanderer und einen Hirtenhorn blasenden Bauern
description: [Hans Conrad Escher von der Linth]
description: Die Beschriftung links unten im Bild ist unleserlich
[Mont Salève]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1782

description: Landschaft mit Hügel und See, Jura-Gebirge im Hintergrund
description: [Hans Conrad Escher von der Linth]
description: Beschriftungen im Bild: "Allées", "champs cultivés", "Eaux vives", "vignes"
Scrapter braunsianus
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter braunsianus

description: Scrapter braunsianus (FRIESE, 1925)spec. rev.
 Polyglossa braunsiana FRIESE, 1925: 517-518. Lectotype ♁ [designated by EARDLEY 1996] (Willowmore, South Africa) (DNMNH), examined.
 Based on outer morphology and male genitalia S. braunsianus is clearly not conspecific with S. capensis (FRIESE 1909) and, thus, its status as a distinct species is here restored. Scrapter braunsianus is closely related to S. leonis COCKERELL and especially females are very similar. Both sexes of S. braunsianus were described by FRIESE (1925) based on specimens collected on the same date at the same locality (15 August 1920, Willowmore) but while the male lectotype was synonymized with S. capensis (EARDLEY 1996: 83) the female was erroneously identified as S. leonis.
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 702, DOI: 10.5281/zenodo.13154583
Scrapter ornatipes COCKERELL 1933
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter ornatipes

description: Scrapter ornatipes COCKERELL, 1933spec. rev.
 Scrapter ornatipes COCKERELL, 1933b: 70. Holotype ♀ (Van Reenen, South Africa) (NHML), examined.
 Based on outer morphology and male genitalia S. ornatipes is clearly not conspecific with S. pallidipennis (COCKERELL) and, thus, its status as a distinct species is here restored.
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 703, DOI: 10.5281/zenodo.13154583
[Thunersee]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1783
Subjects: Berg
Gebirge

description: Blick vom Schlossberg in Thun auf das Aarebecken, Thunersee und Berner Alpen
description: [Hans Conrad Escher von der Linth]
Au Pont
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1784
Subjects: L'Abbaye, Waadt

description: [Hans Conrad Escher von der Linth]
description: Datierung auf dem Blatt: "den 13". Möglicherweise handelt es sich um den 13. September 1784 (vgl. Reisetagebuch auf der CD-ROM, in: René Brandenberger: Hans Conrad Escher von der Linth, Glarus 2002, S. 4 - 6). Brandenberger hält den 26. Juli 1816 für wahrscheinlich.
Scrapter absonus EARDLEY 1996
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter absonus

description: Scrapter absonus EARDLEY, 1996
 Scrapter absonus EARDLEY, 1996: 55-57, figs 27-31. Holotype ♁ (Langjan Nature Reserve, South Africa) (SANC), paratype examined.
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 704, DOI: 10.5281/zenodo.13154583