cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mortality, Morbidity and Health-Seeking Behaviour during the Ebola Epidemic 2014– 2015 in Monrovia Results from a Mobile Phone Survey
Creators: name: Kühne, Anna
name: Lynch, Emily
name: Marshall, Esaie
name: Tiffany, Amanda
name: Alley, Ian
name: Bawo, Luke
name: Massaquoi, Moses
name: Lodesani, Claudia
name: Vaillant, Philippe Le
name: Porten, Klaudia
name: Gignoux, Etienne
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all-cause morbidity and mortality. To quantify mortality and morbidity and describe health-seeking behaviour in Monrovia, Médecins sans Frontières (MSF) conducted a mobile phone survey from December 2014 to March 2015. We drew a random sample of households in Monrovia and conducted structured mobile phone interviews, covering morbidity, mortality and health-seeking behaviour from 14 May 2014 until the day of the survey. We defined an Ebola-related death as any death meeting the Liberian Ebola case definition. We calculated all-cause and Ebola-specific mortality rates. The sample consisted of 6,813 household members in 905 households. We estimated a crude mortality rate (CMR) of 0.33/10,000 persons/day (95%CI:0.25–0.43) and an Ebola-specific mortality rate of 0.06/10,000 persons/day (95%-CI:0.03–0.11). During the recall period, 17 Ebola cases were reported including those who died. In the 30 days prior to the survey 277 household members were reported sick; malaria accounted for 54% (150/277). Of the sick household members, 43% (122/276) did not visit any health care facility. The mobile phone-based survey was found to be a feasible and acceptable alternative method when data collection in the community is impossible. CMR was estimated well below the emergency threshold of 1/10,000 persons/day. Non-Ebola-related mortality in Monrovia was not higher than previous national estimates of mortality for Liberia. However, excess mortality directly resulting from Ebola did occur in the population. Importantly, the small proportion of sick household members presenting to official health facilities when sick might pose a challenge for future outbreak detection and mitigation. Substantial reported health-seeking behaviour outside of health facilities may also suggest the need for adapted health messaging and improved access to health care.
Metabolic Health in Relation to Body Size: Changes in Prevalence over Time between 1997-99 and 2008-11 in Germany
Creators: name: Truthmann, Julia
name: Mensink, Gert
name: Bosy-Westphal, Anja
name: Scheidt-Nave, Christa
name: Schienkiewitz, Anja
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: 610 Medizin

description: Objective: The study examined potential changes in the proportion of metabolic health according to body size categories over time and across strata of sex and age, varying definitions of metabolic health. Methods: We analysed data from national health interview and examination surveys 1997–99 and 2008–11 for adults aged 18–79 years (GNHIES98: N = 6,565; DEGS1: 6,860). Metabolic health as defined by ATPIII criteria was examined across body mass index categories. The Plourde and Karelis criteria were applied in relation to abdominal obesity. Results: Proportions of adults with metabolic health by body size categories were largely stable over time, except for an increasing proportion of metabolically healthy persons with pre-obesity and metabolically healthy women without abdominal obesity. In both surveys proportions of adults meeting ATPIII criteria ranged from approximately 30% among men and women with obesity, to about two thirds of those with pre-obesity to about 93% among those with normal weight. According to Plourde and Karelis criteria proportions ranged from almost 30% among men and women without abdominal obesity to less than 10% among those with abdominal obesity. Proportions were consistently higher among younger than older age groups and less consistently higher among women than men. Conclusions: Proportions of adults with metabolic health by body size categories were largely stable over time, except for an increasing proportion of metabolically healthy women without abdominal obesity. There is no evidence that metabolic health among adults with obesity increased in Germany over a period of ten years.
Additional file 5 of Optimizing LI-RADS: ancillary features screened from LR-3/4 categories can improve the diagnosis of HCC on MRI
Creators: name: Zhang, Zi-xin
name: Xv, Hui
name: Du, Yan-ni
name: Lv, Zhi-bin
name: Yang, Zheng-han
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 5
sj-pdf-2-asm-10.1177_10731911211034564 – Supplemental material for How Universal Is a Construct of Loneliness? Measurement Invariance of the UCLA Loneliness Scale in Indonesia, Germany, and the United States
Creators: name: Hudiyana, Joevarian
name: Lincoln, Tania M.
name: Hartanto, Steffi
name: Shadiqi, Muhammad A.
name: Milla, Mirra N.
name: Muluk, Hamdi
name: Jaya, Edo S.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-2-asm-10.1177_10731911211034564 for How Universal Is a Construct of Loneliness? Measurement Invariance of the UCLA Loneliness Scale in Indonesia, Germany, and the United States by Joevarian Hudiyana, Tania M. Lincoln, Steffi Hartanto, Muhammad A. Shadiqi, Mirra N. Milla, Hamdi Muluk and Edo S. Jaya in Assessment
Xenotransplantation — A special case of One Health
Creators: name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: Xenotransplantation
subject: Public health
subject: Pigs
subject: Diabetes
subject: Virus safety
subject: Porcine viruses
subject: 610 Medizin

description: The chronic shortage of human transplants to treat tissue and organ failure has led to the development of xenotransplantation, the transplantation of cells, tissues and organs from another species to human recipients. For a number of reasons, pigs are best suited as donor animals. Successful, routine xenotransplantation would have an enormous impact on the health of the human population, including the young, who sometimes require a replacement organ or islet cells, but especially the elderly, who more often suffer the consequences of organ failure. The first form of xenotransplantation applied to humans is the use of pig islet cells to treat insulin-dependent diabetes, a procedure that will have a significant economic impact. However, although xenotransplantation using pig cells, tissues and organs may save and prolong the lives of patients, it may also be associated with the transmission of porcine microorganisms to the recipient, eventually resulting in emerging infectious diseases. For this reason, the health of both the donor animals and the human recipients represents a special and sensitive case of the One Health concept. Basic research leading to strategies how to prevent transmission of porcine microorganisms by selection of virus-free animals, treatment of donor pigs by antiviral drugs, vaccines, colostrum deprivation, early weaning, Caesarean delivery, embryo transfer and/or gene editing should be undertaken to supply an increasing number of potential recipients with urgently required transplants. The methods developed for the detection and elimination of porcine microorganisms in the context of xenotransplantation will also contribute to an improvement in the health of pig populations in general and an increase in the quality of meat products. At present, there is evidence for transmission of porcine viruses to humans eating pork and having contact with pigs, however the impact of these viruses on public health is still unknown.
Direct Numerical Simulation of Marangoni Flows: Dynamical Regimes and Transitions
Creators: name: Zhang, Qian
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Marangoni flows are free-surface flows driven by gradients of surface tension. Because surface tension depends on chemical composition, Marangoni flows may be generated by the uneven distribution of surface-active species at an interface. The primary goal of this thesis is to develop a rigorous computational framework for the simulation of the fluid dynamical and interfacial phenomena underlying the physics of Marangoni flows. The focus is on characterizing the different dynamical regimes generated by the presence of surface-active species (surfactants) at an interface. The computational framework was developed using direct numerical simulation, that is, by simultaneously solving the full system of partial differential equations governing the free-surface flow and the surfactant transport on a continually deforming interface. Results from the simulations enabled detailed examination of the interfacial mechanisms of surfactant transport and provided a comprehensive picture of the free-surface flow. Analysis of the results established limits of applicability of scaling solutions previously proposed in the literature, calculated the necessary corrections, and also lead to the discovery of previously unobserved scaling laws in viscous Marangoni flows. New findings from this research not only enhance the fundamental understanding of the physics of Marangoni flows, but also the ability to accurately predict the behaviour of Marangoni flows and the associated transport of surface-active species, which is critical to the understanding of important natural and biomedical processes, ranging from the surfactant-driven propulsion of insects and microorganisms to the spreading of drugs and natural surfactants (proteins) in the eye and lungs. Controlled Marangoni transport of chemical species is also relevant to a wide range of environmental and technological processes, with applications ranging from cleaning of oil spills to coating of microfluidic devices.
Regularity of Powers and Products of Ideals
Creators: name: JAFARI, SEPEHR
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: The aim of this thesis is to study the Castelnuovo-Mumford regularity of powers and products of ideals of polynomial rings. In general, it is known that the regularity of large enough powers of ideals are given by a linear function. Moreover, similar result holds for products of large enough powers of ideals which are generated in the same degrees.
These are fascinating results, however, there are still missing mysteries on specics of the asymptotic linear functions. For example, the stabilizing index (the smallest power for which the regularity is a linear function) and the so called constant (the constant term in the linear function) is unknown in general. We compute these two missing parts for two deferent classes of ideals using two deferent methods.
Additional file 6 of Optimizing LI-RADS: ancillary features screened from LR-3/4 categories can improve the diagnosis of HCC on MRI
Creators: name: Zhang, Zi-xin
name: Xv, Hui
name: Du, Yan-ni
name: Lv, Zhi-bin
name: Yang, Zheng-han
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 6
Work-related physical activity among adults in Germany
Creators: name: Finger, Jonas D.
name: Mensink, Gert
name: Lange, Cornelia
name: Manz, Kristin
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: ADULTS
subject: HEALTH MONITORING
subject: PHYSICAL INACTIVITY
subject: WORK
subject: SITTING
subject: 610 Medizin

description: In GEDA 2014/2015-EHIS the prevalence of work-related physical activity was estimated based on respondents’ self-reported data. 47.5% of women and 47.2% of men mostly sit or stand during work. The highest proportion of people who mostly sit or stand during work is found among 18- to 29-year-old women (55.5%) and men aged 30 to 44 (50.2%). A significantly higher proportion of men (14.8%) than women (3.2%) have jobs involving mostly heavy manual labour. For both genders, the higher a person’s level of education, the more likely it is that physical activity during work is limited to sitting or standing. The results highlight great potential to promote physical activity.
Supplemental material for this article is available online.
Creators: name: Zheng, Lucy R.
name: Oberle, Catherine M.
name: Hawkes-Robinson, W. A.
name: Daniau, Stéphane
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Science Policy

description: Supplemental Material for Serious Games as a Complementary Tool for Social Skill Development in Young People: A Systematic Review of the Literature by Lucy R. Zheng, Catherine M. Oberle, W. A. Hawkes-Robinson and Stéphane Daniau, in Simulation & Gaming
Welfare aziendale e reti: prospettive di sviluppo e analisi di due best practice italiane
Creators: name: GRANDI, Daniele
Publisher: name: Universit� degli studi di Bergamo
Year: 2017

description: La crisi dello stato sociale, che si trascina da quasi quarant?anni, unitamente agli effetti della crisi economica del 2007 hanno portato l?attenzione di imprese e istituzioni sul tema del welfare aziendale quale potenziale anello di congiunzione tra la ricerca di nuovi modelli per la competitivit� delle imprese e il processo di ricalibratura del welfare pubblico.
Tuttavia, in Italia il fenomeno riguarda un numero ancora molto limitato di imprese ? in prevalenza di grandi dimensioni -, prevalgono misure ancora non pienamente in grado di intercettare efficacemente i nuovi bisogni sociali e non si � ancora registrato un forte sviluppo di modelli in grado di coinvolgere il territorio per la generazione di reti di servizi che possano inserirsi a pieno titolo in un sistema di ?secondo welfare?, ovvero un?arena in cui attori di natura diversa ? fondazioni, associazioni, organizzazioni sindacali, associazioni datoriali, imprese, eccetera ? mobilitano risorse non pubbliche per sviluppare servizi in grado di sostenere ed integrare il welfare pubblico da un punto divista quali-quantitativo.
Uno dei modi per coniugare tali aspetti e contribuire allo sviluppo del welfare aziendale � ritenuto essere l?aggregazione tra aziende in rete.
L?obbiettivo del presente lavoro � quello di fare chiarezza su quelle che possono essere le criticit� e i vincoli, nonch� il potenziale, delle reti nate per creare servizi di welfare comuni tra le aziende aderenti e valutare se effettivamente quello della rete pu� essere uno strumento in grado di portare a uno sviluppo del welfare aziendale in chiave territoriale e a portata delle imprese di piccole e medie dimensioni.
La ricerca � stata svolta tramite la metodologia dello ?studio di caso? e ha visto il coinvolgimento di due importanti realt� italiane.
I risultati mostrano che le reti nate per la creazione di misure di welfare comuni possono agevolare l?avvicinamento delle PMI al tema del welfare aziendale e possono rappresentare un potenziale laboratorio di sperimentazione sul territorio per nuovi servizi in risposta a nuovi bisogni. Tuttavia, per facilitare tali processi occorre prestare particolare attenzione, in fase di progettazione della rete, alle caratteristiche di quello che sar� il territorio di riferimento, ai sistemi di relazioni industriali delle aziende partecipanti e ai meccanismi di regolamentazione interna.
20130326 ORCID Audit Committee Charter
Creators: name: Haak Laurel
name: Pentz, Edward
Publisher: name: Figshare
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: ORCID's Audit Committee Charter was originally approved by the Board on 2013-03-26. Committee membership is updated annually and the most recent revision was on 2017-04-03.
A CONCEPTUAL FRAMEWORK FOR DISTRIBUTED SOFTWARE QUALITY NETWORK
Creators: name: PATIL, ANUSHKA HARSHAD
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Software engineering not elsewhere classified
Distributed computing and systems software not elsewhere classified

description: The advancement in technology has revolutionized the role of software in recent years. Software usage is practically found in all areas of the industry and has become a prime factor in the overall working of the companies. Simultaneously with an increase in the utilization of software, the software quality assurance parameters have become more crucial and complex. Currently the quality measurement approaches, standards, and models that are applied in the software industry are extremely divergent. Many a time the correct approach will wind up to be a combination of di erent concepts and techniques from di erent software assurance approaches [1]. Thus, having a platform that provides a single workspace for incorporating multiple software quality assurance approaches will ease the overall software quality process. In this thesis we have proposed a theoretical framework for distributed software quality assurance, which will be able to continuously monitor a source code repository; create a snapshot of the system for a given commit (both past and present); the snapshot can be used to create a multi-granular blockchain of the system and its metrics (i.e.,metadata) which we believe will let the tool developers and vendors participate continuously in assuring quality and security of systems and in the process be accessible when required while being rewarded for their services.
Још понешто о лексемама Шиптари и Албанци и о другим терминолошким питањима у Срба
Creators: name: Радић, Првослав
Publisher: name: Zenodo
Year: 2024
Subjects: српски језик
србистика
језичка политика
лингвополитика
linguistic‑political studies
Serb language

description: ● Несумњиво је да је термин Шиптар (прид. шиптарски), као и некадашњи термин Арбанас (прид. арбанашки), у етничком значењу веома старе употребе у Срба, обједињујући територијално (супротно неким новијим тврдњама) и главнину становништва из области која се данас назива државом Албанијом и делове мање-више истородног становништва из појединих суседних области у Црној Гори, Србији, Македонији и Грчкој.● У вези с тим, Србима се у недостатку јасних аргумената подмеће и домишљена, лажна теза о наводно погрдном значењу термина Шиптар, иако су у српском језику као несумњиво погрдни издвојени неки други облици, тј. изведенице од ове речи (нпр. Шипац, Шиптарела и др.). Тиме се српски народ жигоше као „политички некоректан“, па унеколико и нецивилизован.● Тако, не треба много мудрости како би се закључило да је и термин Албанац у етничком значењу лансиран с политичким предумишљајем да (за почетак терминолошки) обједини Шиптаре из Црне Горе, Србије, Македоније и Грчке око Албаније као своје матице, те да се он суседним народима (не-Шиптарима) наметне с позиција великоалбанске идеологије, тј. политичког пројекта Велике Албаније.● Ко, дакле, држи до традиције у српском народу, али и у српској науци и култури, ко јасно препознаје и свој национални идентитет и идентитет културе којој припада, он неће олако учествовати у насиљу над својим језиком, које, свакако не случајно, ових деценија врхуни у српском друштву, обилато финансијски и свакојако другачије подржаном извана (исп. нпр. случај наметнуте тзв. феминизације језика). У том светлу, он неће напуштати ни изворну терминологију, која је заједно са српским језиком на својеврстан начин и део српске нематеријалне културне баштине.
The antimicrobial peptide SET-M33. Strategies to improve the manufacturing procedures and production of back-up molecules as novel antibiotics
Creators: name: CASTIGLIA, FRANCESCA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The synthetic antimicrobial peptide SET-M33 is being developed as a possible new antibacterial candidate for the treatment of multi-drug resistant bacteria. SET-M33 is a branched peptide featuring higher resistance and bioavailability than its linear analogues. SET-M33 shows antimicrobial activity against different species of multi-resistant Gram-negative bacteria, including clinically isolated strains of Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumanii and Escherichia coli. In this thesis are repoted strategies to improve the biopharmaceutical development and manufacturing process of this peptide. First, the secondary structure of SET-M33 was investigated by NMR to fully characterize the product in the framework of preclinical studies. Since the final formulation of SET-M33 will be strictly defined in terms of counter-ions and additives, It is also reported the studies on a new salt formulation, SET-M33 chloride, that retains its activity against Gram-negative bacteria and gains in solubility, with a possible improvement in the pharmacokinetic profile. The opportunity of using a chloride counter-ion is very convenient to decrease the manufacturing peptide cost and did not increase the toxicity of the antimicrobial drug.
In addition, to identify back-up molecules, a panel of modified versions of SET-M33 was tested in order to produce new molecules with better performance in terms of pharmaceutical profile and manufacturing costs. Amongst them, the opportunity of using SET-M33D-L-Ile and SET-M33D-Leu/Ile will allow to decrease the costs in the synthesis process and SET-M33-Gly/Ala, to eliminate the degradation site for bacterial proteases, without altering the strong antimicrobial activity of the original peptide.
Finally cloning strategies, expression systems, purifications and structural characterizations of various proteins of mammalian inflammasomes performed at Boston Children's Hospital, affiliated with Harvard Medical School, are described.
Esiti di un processo unicizzante o parole storicamente sprovviste di autonomia collocazionale? Uno sguardo alla diacronia delle cranberry words in italiano
Creators: name: Obstova, Zora
Publisher: name: Universit� degli studi di Bergamo
Year: 2018

description: The present study deals with extremely restricted collocability in Italian and analyses the
phenomenon from a historic perspective. By following the diachronic development of a
sample of lexemes and word-forms with strongly limited combinatorial potential and often
lacking in both syntactic and semantic autonomy (these forms are usually referred to as
cranberry words or monocollocable words), extracted from corpora, and the fixed
combinations in which they occur, it tries to shed light on the origin of these peculiar
words and on the lexicalisation processes of multiword expressions with a monocollocable
component in Italian. One of the principal aims of the paper is to verify the widespread
hypothesis that cranberry words are the result of a diachronic process leading to a
progressive loss of combinatorial possibilities of originally autonomous lexemes. The
diachronic analysis shows that the situation is much more complex: only some of the
examined words can be considered archaisms (or historisms), whereas many
monocollocable forms are characterised, historically, by combinatorial restrictions,
appearing in the language already as components of multiword units. Furthermore, some
of the studied examples suggest that the ?unicalisation? process is not unidirectional and
that there is a constant exchange between free lexemes and distributionally idiosyncratic
items contributing to an incessant enrichment of the lexicon.
title: The Likens' problem: a journey in systems ecology
title: Presenting the Habilitation Thesis "Contributions to the development of theoretical biologyand of interdisciplinary directions at the interfacebetween life sciences and earth system science"
titleType: Subtitle
Creators: name: Iordache, Virgil Alexandru
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Biogeochemistry
subject: systems ecology
subject: plant sciences
subject: toxic elements
subject: Sustainability sciences

description: To provide a narrative, I have framed the contributions of this habilitation thesis in the Likens’ problem. Indeed, the research program evolved toward understanding how plant stress controls the fluxes of elements by underground and surface fluxes in small catchments.

While the structural model of the original Hubbard Brook experiment was simple and pragmatic, our work started from an overwhelmingly complex holistic approach. The theoretical and methodological contributions aimed to reduce the approach’s dimensionality and meaningfully focus on biological compartments with key roles in the target biogeochemical processes.

This effort led to a modular research strategy combining processes over scales and discretization in ecological objects, several experimental scales, and nested grids of fieldwork sampling, which was applied to areas contaminated with heavy metals. 

Not mentioned in the presentation, but equally crucial for the program’s success was the hybridization between the Romanian fieldwork tradition and the experimental rigor of the Jena School of bio-geo interactions in mining areas. More information can be found at https://zenodo.org/records/13684611 

This kind of work is interdisciplinary by its very nature, spanning from ecophysiology to catchment scale modeling. It becomes transdisciplinary when developing the needed research ecosystems and transferring knowledge describing ecosystem services to decision-makers.

The specific conclusions in each direction have been summarized in the concluding part of the habilitation thesis, available at https://zenodo.org/records/13684356. The research directions will be developed with the Hubbard Brook research ecosystems and the Jena Bio geo interactions school in the frame of a European network.
Additional file 1 of Relationships between drinking habits, psychological resilience, and salivary cortisol responses on the Trier Social Stress Test-Online among Japanese people
Creators: name: Ueno, Masaharu
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
Classification of Receptor-Like Cytoplasmic Kinases in Maize and Functional Analysis of ZmBLK1
Creators: name: Li, Weiran
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Plant pathology

description: Receptor-like cytoplasmic kinases (RLCKs) form a large family of proteins in plants. RLCKs have been found in different plant species, regulating plant immunity to different bacterial and fungal pathogens. Previous studies implicated Arabidopsis botrytis induced kinase1 (BIK1) and tomato protein kinase 1b (TPK1b) in plant resistance to Pseudomonas syringae and Botrytis cinerea. In this study, we classified 195 putative maize RLCKs into ten subfamilies. Based on the amino acid sequence similarity to BIK1 and TPK1b, a novel maize RLCK, zea mays bik1-like kinase 1 (ZmBLK1) was identified. Enzyme assays with cloned ZmBLK1 revealed a functional kinase when expressed in planta. The recombinant protein located to the plasma membrane. Expression of ZmBLK1 is highest in maize leaves compared to other structures at silking stage. Expression of the recombinant ZmBLK1 significantly reduced the rate of lesion spread in maize leaves inoculated with the Goss’s wilt pathogen. In maize kernels, expression of ZmBLK1 increases during kernel maturation. Kernels from transgenic maize overexpressing ZmBLK1 were not resistant to Aspergillus flavus or to aflatoxin contamination. In addition, mutations were made in ZmBLK1 that were hypothesized to create a constitutively active kinase. However, resulting proteins had similar activity to the wild-type ZmBLK1 and transgenic plants showed similar responses to the Goss’s wilt and Aspergillus ear rot pathogens. Overall, this research established the first characterization of RLCKs in maize and described a potential contribution of ZmBLK1 to maize immune responses.
Additional file 1 of Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
Creators: name: Zhou, Yifan
name: Qin, Yao
name: Ma, Jingjing
name: Li, Zhiyuan
name: Heng, Weiwei
name: Zhang, Lei
name: Liu, Hong
name: Li, Ruowei
name: Zhang, Miaomiao
name: Peng, Qiao
name: Ye, Pei
name: Duan, Ning
name: Liu, Ting
name: Wang, Wenmei
name: Wang, Xiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1. 16S rRNA partial sequence of P. intermedia in the NCBI database. Figure S2. The number of differentially expressed genes induced by heat-killed P. intermedia in the transplanted OSCC tumors of mice by transcriptomic analyses. Figure S3. Chord diagrams showing the effect of heat-killed P. intermedia on the transcriptomics of differential genes and pathways.
Supplemental Material, sj-pdf-3-pch-10.1177_21501351211007102 - “No Official Help Is Available”—Experience of Parents and Children With Congenital Heart Disease During COVID-19
Creators: name: Marino, L. V.
name: Wagland, R.
name: Culliford, D. J.
name: Bharucha, T.
name: Sodergren, S. C.
name: Darlington, Anne-Sophie E.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 111403 Paediatrics
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental Material, sj-pdf-3-pch-10.1177_21501351211007102 for “No Official Help Is Available”—Experience of Parents and Children With Congenital Heart Disease During COVID-19 by L. V. Marino, R. Wagland, D. J. Culliford, T. Bharucha, S. C. Sodergren and Anne-Sophie E. Darlington in World Journal for Pediatric and Congenital Heart Surgery
Phytocannabinoids: Novel chemistry of Biological relevance
Creators: name: MATTOTEIA, Daiana
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2021

description: Phytocannabinoids are the hallmark secondary metabolites of C. sativa, a plant cogently described by Mechoulam as a ?neglected pharmacological treasure trove? of bioactive compounds. Even though phytocannabinoids have been extensively investigated throughout the past decades, many aspects of their chemistry and biological profile still need clarification, and the aim of this thesis was to fill these gaps and find new avenues of exploitation for their biological potential. Seen in retrospect, a considerable section of the thesis is based on the reactivity o phytocannabinoids towards iodine, which ? in different oxidation states ? proved to be a remarkably enabling and versatile manoeuvre of chemical modification.
The investigation of the possible generation of narcotic ?9-tetrahydrocannabinols (THCs) during the pyrolysis of the non-narcotic cannabinoid cannabichromene (CBC) led to the discovery of a deconstructive annulation driven by molecular iodine that eventually led to the development of a simple one-step synthesis of cannabinol (CBN) from two simple precursors (olivetol and citral). Iodine, in the hypervalent form of SIBX, also played a central role in the oxidation of resorcinyl cannabinoids to their corresponding cannabinoquinones, a reaction of considerable relevance in medicinal chemistry owing to the ongoing clinical development of a compound of this class (VCE-004.8). The chemistry of two overlooked classes of cannabinoids, the cannabichromenoids and dimethylheptylcannabinoids was also investigated, providing the basis for the clarification of their biological potential.
Development of a Cross-platform Algorithm for Application of Digital Holography in 3D Particle Detection
Creators: name: Wang, Yijie
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Digital holography (DH) has a variety of applications on measuring the 3D position of different kinds of particles, including the droplets created in drop breakups, seeding particles for flow velocity measurements, characterizations of the behavior of the microorganisms, etc. A particle detection method is required to extract the 3D information encoded in the interference patterns of the holograms, which is desired to be accurate and fast. As the accuracy of the particle detection method improves, the time efficiency of the method decreases. In this study, an optimization process is developed based on an existing method to shorten the processing time. The optimization process includes reducing the complexity of the method and introducing the parallel processing algorithm that can be implemented on cluster machines. The existing particle detection method is separated into several steps and analyzed. The most time consuming step, refining the threshold to separate overlapping particles, is the focus of complexity reduction optimization. A Python code is developed, based on object oriented programming, to implement the optimization. Message Passing Interface (MPI) is applied for parallel processing with a 24-core remote workstation. The optimized Python code is compared with the existing Matlab code in both time consumption and accuracy aspects with synthetic holograms. It is found that the optimization process is able to reduce the time consumption by about four times with an acceptable sacrifice in accuracy. Finally, a DIH system with the optimized method, is applied to characterize different kinds of solid particles. One is noted that the previous studies focus on measuring artificial particles or droplets which are both spherical particles, while most natural solid particles usually have irregular shapes. Equivalent diameter, circularity and aspect ratio are introduced to quantify the dimension and morphology of the irregular shapes. The statistics of the parameters are generated to characterize different kinds of the particles. The accuracy of the characterization of the particles are verified with the observation of the microscopic images of the particles, which can further prove the improvement of the optimized method for particle detection.
A FRAMEWORK FOR OPTIMIZING PROCESS PARAMETERS IN POWDER BED FUSION (PBF) PROCESS USING ARTIFICIAL NEURAL NETWORK (ANN)
Creators: name: Marrey, Mallikharjun
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Additive manufacturing
Manufacturing processes and technologies (excl. textiles)
Mechanical engineering not elsewhere classified
Metals and alloy materials

description: Powder bed fusion (PBF) process is a metal additive manufacturing process, which can build parts with any complexity from a wide range of metallic materials. Research in the PBF process predominantly focuses on the impact of a few parameters on the ultimate properties of the printed part. The lack of a systematic approach to optimizing the process parameters for a better performance of given material results in a sub-optimal process limiting the potentialof the application. This process needs a comprehensive study of all the influential parameters and their impact on the mechanical and microstructural properties of a fabricated part. Furthermore, there is a need to develop a quantitative system for mapping the material properties and process parameters with the ultimate quality of the fabricated part to achieve improvement in the manufacturing cycle as well as the quality of the final part produced by the PBF process. To address the aforementioned challenges, this research proposes a framework to optimize the process for 316L stainless steel material. This framework characterizes the influence of process parameters on the microstructure and mechanical properties of the fabricated part using a series of experiments. These experiments study the significance of process parameters and their variance as well as study the microstructure and mechanical properties of fabricated parts by conducting tensile, impact, hardness, surface roughness, and densification tests, and ultimately obtain the optimum range of parameters. This would result in a more complete understanding of the correlation between process parameters and part quality. Furthermore, the data acquired from the experimentsare employed to develop an intelligent parameter suggestion multi-layer feedforward (FF) backpropagation (BP) artificial neural network (ANN). This network estimates the fabrication time and suggests the parameter setting accordingly to the user/manufacturers desired characteristics of the end-product. Further, research is in progress to evaluate the framework for assemblies and complex part designs and incorporate the results in the network for achieving process repeatability and consistency.
Targeted therapies in lung adenocarcinomas: new methodologies and new markers
Creators: name: EPISTOLIO, SAMANTHA
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2018

description: Il cancro ai polmoni � la patologia neoplastica con il tasso di mortalit� pi� elevato. L?adenocarcinoma (AC), che rappresenta il 60% dei tumori polmonari non a piccole cellule (NSCLC), � l?istotipo pi� diffuso e attaualmente viene trattato mediante resezione chirurgica combinata con un regime chemioterapico basato su platino (Pt) abbinato ad una coppia di molecole citotossiche. Con lo scopo di risolvere gli svantaggi del trattamento chemioterapico, negli ultimi anni sono stati sviluppati farmaci a bersaglio molecolare. Le terapie molecolari maggiormente utilizzate per gli AC polmonari sono gli inibitori tirosin-chinasici (TKIs) diretti contro il recettore del fattore di crescita dell?epidermide (EGFR) e contro la chinasi del linfoma anaplastico (ALK). Lo scopo del mio progetto � stato quello di migliorare la cura dei pazienti affetti da AC polmonare sia tramite l?implementazione dei saggi per analizzare EGFR in campioni tissutali e biopsie liquide sia tramite la valutazione dell?espressione di un nuovo possibile bersaglio di farmaci molecolari: il recettore tirosin-chinasico orfano da ligando-1 (ROR1). I nuovi saggi (SensiScreen�) sono stati validati su due coorti retrospettive di pazienti affetti da AC polmonare: la prima rappresentata da 471 campioni di tessuto e la seconda rappresentata da 61 campioni di plasma, 5 di siero e 39 di tessuto dagli stessi pazienti. SensiScreen� conferma le mutazioni trovate con DS e con le altre metodologie, ma soprattutto permette di analizzare alcuni casi risultati non valutabili con gli altri saggi e consente di trovare nuovi casi mutati. L?espressione di ROR1 e di miR-382 (un microRNA, miRNA, coinvolto nell?inibizione di ROR1) � stata valutata con TaqMan real-time PCR in una terza coorte retrospettiva costituita da 102 pazienti affetti da AC polmonare. Le nostre analisi dimostrano un?overespressione di ROR1 e di miR-382 nel 28.6% e nel 48.1% dei casi rispettivamente.
The Affordances of Laughter in an Afterschool STEM Program for Multilingual Learners
Creators: name: Wright, Casey Elizabeth
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Learning sciences

description: All though laughter is traditionally thought of as divergent from the goals of science learning, this perspective seems to be a cursory assumption about which little empirical evidence is provided. Taking a situated and embodied approach to learning, this study details the affordances of laughter in an afterschool STEM program for resettled Burmese refugee high school youth. The informal learning setting in the afterschool program provides a space where laughter is often present, yet the meanings of laughter in these settings are not well understood. Through micro analysis of video data collected from the afterschool setting, three interactions between youth and facilitators in the setting were examined to investigate the work that youth’s laughter does in the moment to challenge insular concepts of science discourse. Interaction ritual analysis was used theorize the examined interactions’ connections to other moments in the learning setting. In doing so, the affordances of laughter were found to be its work in generating solidarity, democratizing power relations, and providing ways to deal with uncertainty in science. Overall, findings from this research indicate that the informal learning context and responsive pedagogy provided important localities for youth to draw on their resources and they do so even in seemingly insignificant moments along the margins of what is traditionally considered to be science discourse.
sj-pdf-6-asm-10.1177_10731911211034564 – Supplemental material for How Universal Is a Construct of Loneliness? Measurement Invariance of the UCLA Loneliness Scale in Indonesia, Germany, and the United States
Creators: name: Hudiyana, Joevarian
name: Lincoln, Tania M.
name: Hartanto, Steffi
name: Shadiqi, Muhammad A.
name: Milla, Mirra N.
name: Muluk, Hamdi
name: Jaya, Edo S.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-6-asm-10.1177_10731911211034564 for How Universal Is a Construct of Loneliness? Measurement Invariance of the UCLA Loneliness Scale in Indonesia, Germany, and the United States by Joevarian Hudiyana, Tania M. Lincoln, Steffi Hartanto, Muhammad A. Shadiqi, Mirra N. Milla, Hamdi Muluk and Edo S. Jaya in Assessment
Additional file 1 of The IMPACT survey: a mixed methods study to understand the experience of children, adolescents and adults with osteogenesis imperfecta and their caregivers
Creators: name: Westerheim, Ingunn
name: Hart, Tracy
name: van Welzenis, Taco
name: Wekre, Lena Lande
name: Semler, Oliver
name: Raggio, Cathleen
name: Bober, Michael B.
name: Rapoport, Maria
name: Prince, Samantha
name: Rauch, Frank
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 1. IMPACT Survey Questionnaire.
UNRAVELING MOLECULAR MECHANISMS UNDERLYING MEIS1ONCOGENIC ACTIVITY; POSSIBLE COMPETITION WITH PREP1
Creators: name: DARDAEI ALGHALANDIS, LEILA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Meis1 and Prep1 homeodomain-containing transcription factors are essential for the normal embryonic development of several tissues and organs. Although they both can recruit Pbx at least for some of their biological function using the same homology region, the Meis1-Pbx and Prep1-Pbx complexes bind different DNA sequences and play opposite roles in tumorigenicity. In cancer, Meis1 has been extensively implicated in leukemia and neuroblastoma. Overexpression of Meis1 greatly shortens the latency and affects the penetrance of myeloid leukemia induced by Hox genes retroviral transduction. Furthermore, Meis1 has essential oncogenic function in all human leukemic MLL- translocation. Although, Meis1 is strongly suggested for involvement in human neuroblastoma and glioma, its function in non-hematological malignancies and solid tumors remains poorly defined. In contrast, Prep1 does not accelerate Hox-induced leukemogenesis. In fact heterozygous or homozygous Prep1-deficient mice develop tumors at high frequency. In mice, Prep1 haploinsufficiency causes spontaneous tumor formation and accelerates development of tumors in E?Myc transgenic mice. In human tumors, PREP1 is absent or downregulated in a large fraction of tumors including lung, breast and colon cancers. Therefore, Prep1 exerts tumor suppressor function in the cell by maintaining genomic stability and hence preventing neoplastic transformation.
Here I show that Meis1 is involved in malignant transformation of Prep1-deficient MEFs and that this can be partially rescued by re-expression of Prep1. I demonstrate that the Pbx-interacting domain of Prep1 is involved in its tumor suppressor function. Moreover, Both Meis1 and Prep1 require Pbx1 for their oncogenic and tumorsppressive functions, respectively. Therefore Meis1 and Prep1 do compete for Pbx1 in the context of tumor development. Furthermore, I find Meis1 interacts with Ddx3x and Ddx5 RNA helicases,which is perturbed in the presence of Prep1. Together, the presented results suggest that Meis1 is a bona-fide oncogene also in non-hematic cells and that Prep1 impairs Meis1 tumorigenicity by either competing for Pbx1 or preventing its interaction with transcriptionally relevant partners.
sj-pdf-2-pmj-10.1177_02692163211032114 – Supplemental material for Professionals’, patients’ and families’ views on the use of opioids for chronic breathlessness: A systematic review using the framework method and pillar process
Creators: name: Reedy, Florence
name: Pearson, Mark
name: Greenley, Sarah
name: Clark, Joseph
name: Currow, David C
name: Bajwah, Sabrina
name: Fallon, Marie
name: Johnson, Miriam J
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-pmj-10.1177_02692163211032114 for Professionals’, patients’ and families’ views on the use of opioids for chronic breathlessness: A systematic review using the framework method and pillar process by Florence Reedy, Mark Pearson, Sarah Greenley, Joseph Clark, David C Currow, Sabrina Bajwah, Marie Fallon and Miriam J Johnson in Palliative Medicine