cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
Creators: name: Napso, Tina
name: Hung, Yin-Po
name: Davidge, Sandra T.
name: Care, Alison S.
name: Sferruzzi-Perri, Amanda N.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/136
/631/443/494
/38
/82/80
/13/2
/13/51
article

description: Funder: TN is supported by an EU Marie Skłodowska-Curie Fellowship (PlaEndo/703160).
description: Funder: SD is supported as a Canada Research Chair in Maternal and Perinatal Cardiovascular Health. The animal work was funded by grants to SD from the Canadian Institutes of Health Research (CIHR: MOP 133675, FS 154313) and the Women and Children’s Health Research Institute (WCHRI) through the generosity of the Stollery Children’s Hospital Foundation and supporters of the Lois Hole Hospital for Women
description: Abstract: Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3–4 months) dams, advanced maternal age (9.5–10 months) compromises growth of both female and male fetuses but affects the placental phenotype sex-specifically. In placentas from aged versus young dams, the size of the placental transport and endocrine zones were increased and expression of Igf2 (+41%) and placental lactogen (Prl3b1: +59%) genes were upregulated in female, but not male fetuses. Placental abundance of IGF2 protein also decreased in the placenta of males only (−95%). Moreover, in placentas from aged versus young dams, glucocorticoid metabolism (11β-hsd2: +63% and 11β-hsd1: −33%) was higher in females, but lower in males (11β-hsd2: −50% and 11β-hsd1: unaltered). There was however, no change in the placental abundance of 11β-HSD2 protein in aged versus young dams regardless of fetal sex. Levels of oxidative stress in the placenta were increased in female and male fetuses (+57% and +90%, respectively) and apoptosis increased specifically in the placenta of males from aged rat dams (+700%). Thus, advanced maternal age alters placental phenotype in a sex-specific fashion. These sexually-divergent changes may play a role in determining health outcomes of female and male offspring of aged mothers.
From grains to pebbles: the influence of size distribution and chemical composition on dust emission properties
Creators: name: Ysard, N.
name: Koehler, M.
name: Jimenez-Serra, I.
name: Jones, A. P.
name: Verstraete, L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The size and composition of dust grains are critical in setting the dynamical, physical and chemical evolution of the media in which they are present. Thanks to facilities such as ALMA and in the future the SKA, their thermal emission in the (sub)mm to cm has become a convenient way to trace grain properties. Our aim is to understand the influence of the grain composition and size distribution on the shape of their SED in dense ISM regions such as molecular clouds, prestellar cores, YSOs and protoplanetary discs. Starting from the optical constants defined in the THEMIS model for amorphous hydrogenated carbon and silicate grains in addition to water ice, we define 6 material mixtures representative of the expected dust composition in dense ISM regions. The optical properties of 0.01 micron to 10 cm grains are then calculated with effective medium and Mie theories. The corresponding SEDs are calculated for isolated clouds either externally heated by the ISRF alone or in addition to an internal source. The 3 main outcomes of this study are as follows. First, the dust mass absorption coefficient strongly depends on both its composition and size distribution potentially leading to errors in dust mass estimates by factors up to 3 and 20, respectively. Second, it appears almost impossible to retrieve the grain composition from the (sub)mm to cm SED shape alone as its spectral index for lambda > 3 mm does not depend on composition. Third, using the true dust opacity spectral index to estimate grain sizes may lead to erroneous findings as the observed spectral index can be highly modified by the dust temperature distribution along the line-of-sight, which depends on the specific heating source and on the geometry of the studied region. Based on the interpretation of only the spectral shape of (sub)mm to cm SEDs, the determination of the dust masses, compositions and sizes are highly uncertain.
description: accepted by A&A, abstract modified to match arXiv standards
Effects of Prelay Supplementations of Graded Levels of Alphamune R G on the Performance of Laying Hens
Creators: name: Oluseyi, Babawale
name: Bolu, Stephen A.
name: Olonijolu, Tosin
name: Oluseyi, Babawale
name: Bolu, Stephen A.
name: Olonijolu, Tosin
Publisher: name: Unknown
Year: 2014
Subjects: Crop Production/Industries

description: This study was carried out to determine the effects of age at prelay (15 and 19 weeks) and dietary supplementation of graded levels of Alphamune G (0.00, 0.04, 0.05, 0.06%) on laying performance of pullet chickens. The experiment period was 17 weeks and completely randomized design was employed. Feed intake, nutrient retention, weight gain and feed to gain ratio values were similar (p > 0.05) among birds fed the different dietary inclusion levels of Alphamune G. Hen day production, Haugh unit and Albumen height were significantly high (p < 0.05) for laying hens of fed the control diet. There was also interaction effect of Alphamune G and Age. The interaction of Alphamune G and Age gave the highest value in laying hens of group B fed the 0.05% diet when compared to the control. However, birds fed the 0.06% Alphamune G inclusion level gave the best result in terms of Production characteristics, Cost to benefit ratio expressed as Cost of feed to produce a Dozen Egg and Egg Quality. Also birds of group B gave better results than that of group A except in the Haugh unit value.
The 2dF Galaxy Redshift Survey: correlation functions, peculiar velocities and the matter density of the Universe
Creators: name: Hawkins, E.
name: Maddox, S.
name: Cole, S.
name: Lahav, O.
name: Madgwick, D.
name: Norberg, P.
name: Peacock, J.
name: Baldry, I.
name: Baugh, C.
name: Bland-Hawthorn, J.
name: Bridges, T.
name: Cannon, R.
name: Colless, M.
name: Collins, C.
name: Couch, W.
name: Dalton, G.
name: De Propris, R.
name: Driver, S.
name: Efstathiou, G.
name: Ellis, R.
name: Frenk, C.
name: Glazebrook, K.
name: Jackson, C.
name: Jones, B.
name: Lewis, I.
name: Lumsden, S.
name: Percival, W.
name: Peterson, B.
name: Sutherland, W.
name: Taylor, K.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a detailed analysis of the two-point correlation function, from the 2dF Galaxy Redshift Survey (2dFGRS). We estimate the redshift-space correlation function, xi(s), from which we measure the redshift-space clustering length, s_0=6.82+/-0.28 Mpc/h. We also estimate the projected correlation function, Xi(sigma), and the real-space correlation function, xi(r), which can be fit by a power-law, with r_0=5.05+/-0.26Mpc/h, gamma_r=1.67+/-0.03. For r>20Mpc/h, xi drops below a power-law as is expected in the popular LCDM model. The ratio of amplitudes of the real and redshift-space correlation functions on scales of 8-30Mpc/h gives an estimate of the redshift-space distortion parameter beta. The quadrupole moment of xi on scales 30-40Mpc/h provides another estimate of beta. We also estimate the distribution function of pairwise peculiar velocities, f(v), including rigorously the effect of infall velocities, and find that it is well fit by an exponential. The accuracy of our xi measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of xi(r) and the two redshift-space distortion effects parameterized by beta and velocity dispersion, a. We find beta=0.49+/-0.09 and a=506+/-52km/s, though the best fit values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(sigma), and find that the shape is consistent with models and simulations. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that beta(L=L*,z=0)=0.47+/-0.08, and that the present day matter density of the Universe is 0.3, consistent with other 2dFGRS estimates and independent analyses.
description: 19 pages, revised following referee's report, and accepted by MNRAS. Higher resolution Figures, an animated version of Figure 12 and a colour version of Figure 22 are available from http://www.nottingham.ac.uk/~ppxeh/
Additional file 1 of Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial
Creators: name: Luo, Wenchen
name: Sun, Minli
name: Wan, Jie
name: Zhang, Zhenyu
name: Huang, Jian
name: Zhang, Jinlin
name: Xiong, Wanxia
name: Xia, Lirong
name: Xu, Peiyao
name: Miao, Changhong
name: Zhang, Xuesong
name: Liu, Mingyue
name: Zhong, Jing
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: Supplementary Material 1
Are EUR and GBP different words for the same currency ?
Creators: name: Ausloos, M.
name: Ivanova, K.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The British Pound (GBP) is not part of the Euro (EUR) monetary system. In order to find out arguments on whether GBP should join the EUR or not correlations are calculated between GBP and EUR, including a reconstructed EUR for the time interval from 1993 till June 30, 2000. The distribution of fluctuations of the exchange rates is Gaussian for the central part of the distribution, but has fat tails for the large size fluctuations. Within the Detrended Fluctuation Analysis (DFA) statistical method the power law behaviour describing the root-mean-square deviation of the exchange rate fluctuations is obtained as a function of time for the time interval of interest. The time-dependent exponent evolution of the exchange rate fluctuations is given. Statistical considerations imply that the GBP is already behaving as a true EUR.
description: 10 pages, 5 figures
Dynamical correlations and pairwise theory for the symbiotic contact process on networks
Creators: name: de Oliveira, Marcelo M.
name: Alves, Sidiney G.
name: Ferreira, Silvio C.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The two-species symbiotic contact process (2SCP) is a stochastic process where each vertex of a graph may be vacant or host at most one individual of each species. Vertices with both species have a reduced death rate, representing a symbiotic interaction, while the dynamics evolves according to the standard (single species) contact process rules otherwise. We investigate the role of dynamical correlations on the 2SCP on homogeneous and heterogeneous networks using pairwise mean-field theory. This approach is compared with the ordinary one-site theory and stochastic simulations. We show that our theory significantly outperforms the one-site theory. In particular, the stationary state of the 2SCP model on random regular networks is very accurately reproduced by the pairwise mean-field, even for relatively small values of vertex degree, where expressive deviations of the standard mean-field are observed. The pairwise approach is also able to capture the transition points accurately for heterogeneous networks and provides rich phase diagrams with transitions not predicted by the one-site method. Our theoretical results are corroborated by extensive numerical simulations.
description: 10 pages, 5 figures
Fertilizer Adoption and Use Intensity Among Smallholder Farmers in Northern Ghana: A Case Study of the AGRA Soil Health Project
Creators: name: Martey, Edward
name: Wiredu, Alexander Nimo
name: Etwire, Prince M.
name: Fosu, Mathias
name: Buah, S. S. J.
name: Bidzakin, John
name: Ahiabor, Benjamin D. K.
name: Kusi, Francis
name: Martey, Edward
name: Wiredu, Alexander Nimo
name: Etwire, Prince M.
name: Fosu, Mathias
name: Buah, S. S. J.
name: Bidzakin, John
name: Ahiabor, Benjamin D. K.
name: Kusi, Francis
Publisher: name: Unknown
Year: 2014
Subjects: Labor and Human Capital

description: Northern Ghana is characterized by food insecurity largely due to over reliance on rain-fed agriculture under low farm input conditions. The present study investigated the effect of factors influencing mineral fertilizer adoption and use intensity among smallholder farmers in Northern Ghana. A total of 330 smallholder farmers selected through multi-stage sampling technique were interviewed. Adoption of fertilizer technology was determined by age, nativity, farm size, access to credit, and distance to agricultural office. The result of the truncated regression estimates indicated that income of household head, membership of farmer association, distance to agricultural office, access to input shop, income earning household that do not participate in agricultural development project and income earning male headed household were the significant factors influencing fertilizer use intensity. Distance to agricultural office was a key positive determinant of fertilizer adoption and use intensity. The study recommends improvement in road infrastructure and technical training of agricultural extension agents. Farmer based organization must be trained on regular basis to enhance their productive skills and technology uptake.
To TDE or not to TDE: The luminous transient ASASSN-18jd with TDE-like and AGN-like qualities
Creators: name: Neustadt, J. M. M.
name: Holoien, T. W. -S.
name: Kochanek, C. S.
name: Auchettl, K.
name: Brown, J. S.
name: Shappee, B. J.
name: Pogge, R. W.
name: Dong, Subo
name: Stanek, K. Z.
name: Tucker, M. A.
name: Bose, S.
name: Chen, Ping
name: Ricci, C.
name: Vallely, P. J.
name: Prieto, J. L.
name: Thompson, T. A.
name: Coulter, D. A.
name: Drout, M. R.
name: Foley, R. J.
name: Kilpatrick, C. D.
name: Piro, A. L.
name: Rojas-Bravo, C.
name: Buckley, D. A. H.
name: Gromadzki, M.
name: Dimitriadis, G.
name: Siebert, M. R.
name: Do, A.
name: Huber, M. E.
name: Payne, A. V.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the discovery of ASASSN-18jd (AT 2018bcb), a luminous optical/UV/X-ray transient located in the nucleus of the galaxy 2MASX J22434289--1659083 at $z=0.1192$. Over the year after discovery, Swift UVOT photometry shows the UV SED of the transient to be well modeled by a slowly shrinking blackbody with temperature $T \sim 2.5 \times 10^{4} \rm ~K$, a maximum observed luminosity of $L_\text{max} = 4.5^{+0.6}_{-0.3} \times 10^{44} \rm ~erg ~s^{-1}$, and a radiated energy of $E = 9.6^{+1.1}_{-0.6} \times 10^{51} \rm ~erg$. X-ray data from Swift XRT and XMM-Newton show a transient, variable X-ray flux with blackbody and power-law components that fade by nearly an order of magnitude over the following year. Optical spectra show strong, roughly constant broad Balmer emission as well as transient features attributable to He II, N III-V, O III, and coronal Fe. While ASASSN-18jd shares similarities with Tidal Disruption Events (TDEs), it is also similar to the newly-discovered nuclear transients seen in quiescent galaxies and faint Active Galactic Nuclei (AGNs).
description: 24 pages, 16 figures, 2 machine-readable tables (included as ancillary txt files)
Additional file 2 of Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial
Creators: name: Luo, Wenchen
name: Sun, Minli
name: Wan, Jie
name: Zhang, Zhenyu
name: Huang, Jian
name: Zhang, Jinlin
name: Xiong, Wanxia
name: Xia, Lirong
name: Xu, Peiyao
name: Miao, Changhong
name: Zhang, Xuesong
name: Liu, Mingyue
name: Zhong, Jing
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: Supplementary Material 2
Magnetic fluctuations and superconductivity in YbPd$_2$Sn
Creators: name: Amato, A.
name: Roessli, B.
name: Fischer, P.
name: Bernhoeft, N.
name: Stunault, A.
name: Baines, C.
name: Dönni, A.
name: Sugawara, H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report muon spin relaxation and inelastic neutron measurements on the Heusler system YbPd$_2$Sn. Localised anisotropic and quasi-elastic Yb magnetic fluctuations are observed below $T = 150$K. Both $μ$SR and neutron data indicate a slowing-down of the spin-fluctuations, upon lowering the temperature, similar to that observed in Kondo lattices. The temperature dependence of the quasi-elastic neutron signal is compatible with a crystal-electric field scheme having a $Γ_7^{\rm CEF}$ ground state. The muon depolarization rate exhibits an additional contribution upon decreasing the temperature below $T_{\rm c}$ suggesting a close interplay between magnetic fluctuations and the superconducting state.
description: Author list updated, acknowledgements added
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Creators: name: Trigg, Ricky M.
name: Lee, Liam C.
name: Prokoph, Nina
name: Jahangiri, Leila
name: Reynolds, C. Patrick
name: Amos Burke, G. A.
name: Probst, Nicola A.
name: Han, Miaojun
name: Matthews, Jamie D.
name: Lim, Hong Kai
name: Manners, Eleanor
name: Martinez, Sonia
name: Pastor, Joaquin
name: Blanco-Aparicio, Carmen
name: Merkel, Olaf
name: De Los Fayos Alonso, Ines Garces
name: Kodajova, Petra
name: Tangermann, Simone
name: Högler, Sandra
name: Luo, Ji
name: Kenner, Lukas
name: Turner, Suzanne D.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/67/70
/631/67/1059/2326
/631/67/1059/602
/631/67/2332
/13/1
/13/2
/13/31
/13/51
/13/89
/13/95
/13/106
/13/109
/38/1
/38/22
/38/23
/38/77
/38/89
/38/90
/38/109
/42/47
/42/89
/45/22
/45/23
/45/41
/45/47
/45/77
/49/22
/49/23
/64/60
/64/110
/82/1
/82/29
/82/51
/96/1
/96/2
/96/31
/96/95
/96/106
article

description: Abstract: Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistance mechanisms in ALK-positive neuroblastoma (NB), we herein employ genome-wide CRISPR activation screens of NB cell lines treated with brigatinib or ceritinib, identifying PIM1 as a putative resistance gene, whose high expression is associated with high-risk disease and poor survival. Knockdown of PIM1 sensitizes cells of differing MYCN status to ALK inhibitors, and in patient-derived xenografts of high-risk NB harboring ALK mutations, the combination of the ALK inhibitor ceritinib and PIM1 inhibitor AZD1208 shows significantly enhanced anti-tumor efficacy relative to single agents. These data confirm that PIM1 overexpression decreases sensitivity to ALK inhibitors in NB, and suggests that combined front-line inhibition of ALK and PIM1 is a viable strategy for the treatment of ALK-positive NB independent of MYCN status.
Viscous diffusion and photoevaporation of stellar disks
Creators: name: Matsuyama, Isamu
name: Johnstone, Doug
name: Hartmann, Lee
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The evolution of a stellar disk under the influence of viscous evolution, photoevaporation from the central source, and photoevaporation by external stars is studied. We take the typical parameters of TTSs and the Trapezium Cluster conditions. The photoionizing flux from the central source is assumed to arise both from the quiescent star and accretion shocks at the base of stellar magnetospheric columns, along which material from the disk accretes. The accretion flux is calculated self-consistently from the accretion mass loss rate. We find that the disk cannot be entirely removed using only viscous evolution and photoionization from the disk-star accretion shock. However, when FUV photoevaporation by external massive stars is included the disk is removed in 10^6 -10^7yr; and when EUV photoevaporation by external massive stars is included the disk is removed in 10^5 - 10^6yr. An intriguing feature of photoevaporation by the central star is the formation of a gap in the disk at late stages of the disk evolution. As the gap starts forming, viscous spreading and photoevaporation work in resonance. There is no gap formation for disks nearby external massive stars because the outer annuli are quickly removed by the dominant EUV flux. On the other hand, at larger, more typical distances (d>>0.03pc) from the external stars the flux is FUV dominated. As a consequence, the disk is efficiently evaporated at two different locations; forming a gap during the last stages of the disk evolution.
description: 27 pages, 11 figures, accepted for publication in ApJ
Aulacolambrus hoplonotus
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Parthenopidae
Aulacolambrus
Aulacolambrus hoplonotus

description: Aulacolambrus hoplonotus (Adams & White, 1849)
 Lambrus hoplonotus Adams & White, 1849: 35, pl. 7, fig. 3 [color] [type locality: “ Eastern Seas;” holotype: NHM 1847.21].
 Hawaiian Is. records:
 Parthenope (Aulacolambrus) hoplonotus (Adams & White, 1849) — Rathbun 1906: 885 [Maui].
 Aulacolambrus hoplonotus (Adams & White, 1849) — Hoover 2006: 272, color photograph [O‘ahu].
 Taxonomy. S.H. Tan et al. (1999), S.H. Tan & Ng (2003)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Shallow subtidal, 3–42 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 57, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
Tumor diversity and the trade-off between universal cancer tasks
Creators: name: Hausser, Jean
name: Szekely, Pablo
name: Bar, Noam
name: Zimmer, Anat
name: Sheftel, Hila
name: Caldas, Carlos
name: Alon, Uri
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/67
/631/553
/38/23
/38/39
/45/47
article

description: Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation); doi: https://doi.org/10.13039/501100001711
description: Funder: Abisch-Frenkel-Stiftung (Abisch-Frenkel Foundation); doi: https://doi.org/10.13039/501100007362
description: Abstract: Recent advances have enabled powerful methods to sort tumors into prognosis and treatment groups. We are still missing, however, a general theoretical framework to understand the vast diversity of tumor gene expression and mutations. Here we present a framework based on multi-task evolution theory, using the fact that tumors need to perform multiple tasks that contribute to their fitness. We find that trade-offs between tasks constrain tumor gene-expression to a continuum bounded by a polyhedron whose vertices are gene-expression profiles, each specializing in one task. We find five universal cancer tasks across tissue-types: cell-division, biomass and energy, lipogenesis, immune-interaction and invasion and tissue-remodeling. Tumors that specialize in a task are sensitive to drugs that interfere with this task. Driver, but not passenger, mutations tune gene-expression towards specialization in specific tasks. This approach can integrate additional types of molecular data into a framework of tumor diversity grounded in evolutionary theory.
MOESM2 of Polypharmacy in older patients: identifying the need for support by a community pharmacist
Creators: name: Jean-Baptiste Beuscart
name: Petit, Ségolène
name: Gautier, Sophie
name: Wierre, Patrick
name: Balcaen, Thibaut
name: Jean-Marc Lefebvre
name: Kambia, Nicolas
name: Bertoux, Elisabeth
name: Mascaut, Daniel
name: Barthélémy, Christine
name: Cuny, Damien
name: Puisieux, François
name: Décaudin, Bertrand
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. Topic guide for the medicine cabinet inspection.
Dynamical instability of new-born neutron stars as sources of gravitational radiation
Creators: name: Liu, Yuk Tung
Publisher: name: arXiv
Year: 2001
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The dynamical instability of new-born neutron stars is studied by evolving the linearized hydrodynamical equations. The neutron stars considered in this paper are those produced by the accretion induced collapse of rigidly rotating white dwarfs. A dynamical bar-mode (m=2) instability is observed when the ratio of rotational kinetic energy to gravitational potential energy $β$ of the neutron star is greater than the critical value $β_d \approx 0.25$. This bar-mode instability leads to the emission of gravitational radiation that could be detected by gravitational wave detectors. However, these sources are unlikely to be detected by LIGO II interferometers if the event rate is less than $10^{-6}$ per year per galaxy. Nevertheless, if a significant fraction of the pre-supernova cores are rapidly rotating, there would be a substantial number of neutron stars produced by the core collapse undergoing bar-mode instability. This would greatly increase the chance of detecting the gravitational radiation.
description: Major changes in Section III and some minor changes in the other sections; add an appendix; 17 pages, 12 figures, accepted for publication by Phys. Rev. D
Bounds on CP-violating Higgs-gluon interactions: the case of vanishing light-quark Yukawa couplings
Creators: name: Haisch, Ulrich
name: Hala, Amando
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We investigate CP-violating interactions involving the Higgs boson and gluons within an effective field theory approach, focusing on the specific class of new-physics scenarios where the Yukawa couplings of light quarks are zero or strongly suppressed compared to the standard-model expectations. We compute the contributions of the most relevant higher-dimensional operators of Weinberg type to the electric dipole moment of the neutron (nEDM), which are induced by Feynman diagrams that involve an effective CP-violating Higgs-gluon coupling and top-quark loops. The resulting nEDM sensitivities and prospects are discussed and compared to the existing and expected LHC bounds. We find that future nEDM searches can set non-trivial constraints on CP-violating Higgs-gluon interactions even if the Higgs only couples to the third generation of quarks.
description: 14 pages, 2 figures; v2: added references and discussion of bounds in universal theories; version accepted for publication in JHEP
Agricultural policy decisions in the Uruguay Round: a game-theoretic examination
Creators: name: Kennedy, P. Lynn
name: Kennedy, P. Lynn
Publisher: name: Unknown
Year: 1994
Subjects: subject: Agricultural and Food Policy
subject: International Relations/Trade
subject: Agricultural policy
subject: Game theory
subject: General Agreement on Tariffs and Trade

description: During the Uruguay Round of the GATT negotiations, emphasis has been placed on the reduction of agricultural protection and trade distorting policies. The difficulty in reaching a compromise, particularly between the United States and the European Community, raises the question as to the existence of a negotiated settlement such that both the U.S. and EC can be made better off. This paper, by means of a weighted Political Payoff Function (PPF), attempts to identify such compromises. Through the use of Modele Internationale Simplifie de Simulation (MISS), the U.S. and EC PPF weights are estimated for base years 1986 and 1990. Simulations are performed based on Uruguay Round proposals and using across-the-board reductions in protection levels. Because of the importance of domestic prices in the PPF and their dependence on exchange rates, shocks to the model are introduced by varying the exchange rate levels for both the 1986 and 1990 base periods. These simulations are conducted both with and without the possibility of providing budget compensation to sectors made worse off as a result of the policy change. The results of the analysis show that reductions in protection levels are likely if the liberalization is multilateral and sectors can be compensated for welfare losses. In addition, the simulations suggest that in the case of the U.S., incentive to reduce protection levels increases as the dollar is devalued and decreases as the dollar is revalued.
description: A THESIS SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA - IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY. Advisor: Harald von Witzke
Pharmacological characterisation of novel adenosine A 3 receptor antagonists
Creators: name: Barkan, Kerry
name: Lagarias, Panagiotis
name: Stampelou, Margarita
name: Stamatis, Dimitrios
name: Hoare, Sam
name: Safitri, Dewi
name: Klotz, Karl-Norbert
name: Vrontaki, Eleni
name: Kolocouris, Antonios
name: Ladds, Graham
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/154/436/2387
/631/535/1267
/631/80/86/820
article

description: Funder: Endowment fund for education, Ministry of Finance Republic of Indonesia
description: Abstract: The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential treatments for numerous diseases including asthma. Given the similarity between (adenosine receptors) orthosteric binding sites, obtaining highly selective antagonists is a challenging but critical task. Here we screen 39 potential A3R, antagonists using agonist-induced inhibition of cAMP. Positive hits were assessed for AR subtype selectivity through cAMP accumulation assays. The antagonist affinity was determined using Schild analysis (pA2 values) and fluorescent ligand binding. Structure–activity relationship investigations revealed that loss of the 3-(dichlorophenyl)-isoxazolyl moiety or the aromatic nitrogen heterocycle with nitrogen at α-position to the carbon of carboximidamide group significantly attenuated K18 antagonistic potency. Mutagenic studies supported by molecular dynamic simulations combined with Molecular Mechanics—Poisson Boltzmann Surface Area calculations identified the residues important for binding in the A3R orthosteric site. We demonstrate that K18, which contains a 3-(dichlorophenyl)-isoxazole group connected through carbonyloxycarboximidamide fragment with a 1,3-thiazole ring, is a specific A3R (< 1 µM) competitive antagonist. Finally, we introduce a model that enables estimates of the equilibrium binding affinity for rapidly disassociating compounds from real-time fluorescent ligand-binding studies. These results demonstrate the pharmacological characterisation of a selective competitive A3R antagonist and the description of its orthosteric binding mode. Our findings may provide new insights for drug discovery.
Continuous gravitational waves from neutron stars: current status and prospects
Creators: name: Sieniawska, Magdalena
name: Bejger, Michał
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gravitational waves astronomy allows us to study objects and events invisible in electromagnetic waves. It is crucial to validate the theories and models of the most mysterious and extreme matter in the Universe: the neutron stars. In addition to inspirals and mergers of neutrons stars, there are currently a few proposed mechanisms that can trigger radiation of long-lasting gravitational radiation from neutron stars, such as e.g., elastically and/or magnetically driven deformations: mountains on the stellar surface supported by the elastic strain or magnetic field, free precession, or unstable oscillation modes (e.g., the r-modes). The astrophysical motivation for continuous gravitational waves searches, current LIGO and Virgo strategies of data analysis and prospects are reviewed in this work.
description: 47 pages; 7 figures; published Universe 'Neutron Star Astrophysics' special issue
PLAID: Supporting Computing Instructors to Identify Domain-Specific Programming Plans at Scale
Creators: name: Jain, Yoshee
name: Demirtaş, Mehmet Arif
name: Cunningham, Kathryn
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Pedagogical approaches focusing on stereotypical code solutions, known as programming plans, can increase problem-solving ability and motivate diverse learners. However, plan-focused pedagogies are rarely used beyond introductory programming. Our formative study (N=10 educators) showed that identifying plans is a tedious process. To advance plan-focused pedagogies in application-focused domains, we created an LLM-powered pipeline that automates the effortful parts of educators' plan identification process by providing use-case-driven program examples and candidate plans. In design workshops (N=7 educators), we identified design goals to maximize instructors' efficiency in plan identification by optimizing interaction with this LLM-generated content. Our resulting tool, PLAID, enables instructors to access a corpus of relevant programs to inspire plan identification, compare code snippets to assist plan refinement, and facilitates them in structuring code snippets into plans. We evaluated PLAID in a within-subjects user study (N=12 educators) and found that PLAID led to lower cognitive demand and increased productivity compared to the state-of-the-art. Educators found PLAID beneficial for generating instructional material. Thus, our findings suggest that human-in-the-loop approaches hold promise for supporting plan-focused pedagogies at scale.
description: 21 pages, 11 figures
Aulacolambrus whitei
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Parthenopidae
Aulacolambrus
Aulacolambrus whitei

description: Aulacolambrus whitei (A. Milne-Edwards, 1872)
 Lambrus whitei A. Milne-Edwards, 1872: 260 (material in Adams & White, 1849: 27, pl. 5, fig. 3) [type locality: Borneo; lectotype: NHM 1847.21; paralectotype: NHM 1847.21].
 Hawaiian Is. record:
 Parthenope (Aulacolambrus) whitei A. Milne-Edwards, 1872 — Rathbun 1906: 885, pl. 15, fig. 5 [Moloka‘i].
 Remarks. Recorded from the Hawaiian Is. by Rathbun (1906) but no subsequent records are known from the archipelago.
 Taxonomy. Rathbun (1906), Ng et al.(2008)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Shallow subtidal, 38–57 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 57, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
Implications of the LHCb discovery of CP violation in charm decays
Creators: name: Dery, Avital
name: Nir, Yosef
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The recent measurement of $ΔA_{CP}$ by the LHCb collaboration requires an ${\cal O}(10)$ enhancement coming from hadronic physics in order to be explained within the SM. We examine to what extent can NP models explain $ΔA_{CP}$ without such enhancements. We discuss the implications in terms of a low energy effective theory as well as in the context of several explicit NP models.
2D Transonic Hydrodynamics in General Relativity
Creators: name: Beskin, V. S.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The goal of my lecture is to present the introduction into the hydrodynamical version of the Grad-Shafranov equation. Although not so well-known as the full MHD one, it allows us to clarify the nontrivial structure of the Grad-Shafranov approach as well as to discuss the simplest version of the 3+1-split language -- the most convenient one for the description of the ideal flows in the vicinity of a rotating black hole.
description: full version, in "Accretion Disks, Jets, and High Energy Phenomena in Astrophysics", Proceedings of Session LXXVIII of Les Houches Summer School, Chamonix, France, August 2002, F.Menard, G. Pelletier, G.Henri, V. Beskin, and J. Dalibard eds. (EDP Science: Paris and Springer: Berlin), in preparation
Additional file 1 of Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy
Creators: name: Bang, Chaeeun
name: Park, Min Gyu
name: Cho, In Kyung
name: Lee, Da-Eun
name: Kim, Gye Lim
name: Jang, Eun Hyang
name: Shim, Man Kyu
name: Yoon, Hong Yeol
name: Lee, Sangmin
name: Kim, Jong-Ho
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Storage stability,measured as changes in the size and PDI of D@C-LPs at 4°C and 25°C. Figure S2. Cytotoxicity of Dox-loaded liposomes against various cancer cell lines. Figure S3. In vivo biodistribution of D@C-LP with pre-treatment of CLDN4 antibody. Figure S4. In vivo therapeutic efficacy of Dox-loaded liposomes in a KPC960 xenograft model. A Photographs of excised tumors after treatment. B Ex vivo fluorescence images. C Changes in body weight in treatment groups over the course of 15 days. D H&E staining of major organsafter 15 days. Figure S5. In vivo therapeutic efficacy of Dox-loaded liposomes in a KPC960 orthotopic model. A Average tumor weights of excised primary tumors. B Average tumor weights of excised metastatic tumors. C Changes in body weight in treatment groups over the course of 24 days. D H&E staining of major organsafter 24 days.
Binary stars in Upper Scorpius
Creators: name: Tokovinin, Andrei
name: Briceno, Cesar
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: To address the statistics of binary stars in the 8-Myr old Upper Scorpius star formation region, we conducted speckle-interferometric survey of 614 association members more massive than 0.4 Msun (spectral types earlier than M3V) based on the list of Luhman et al. (2018). We resolved 187 pairs, 55 of those are new discoveries. Using also the published data and the Gaia DR2, a catalog of 250 physical binaries is produced. We carefully estimated detection limits for each target and studied binary statistics in the separation range from 0.06" to 20" (9 to 2800 au), as well as clustering at larger separations. The frequency of companions with mass ratios q>0.3 in this separation range is 0.33+-0.04 and 0.35+-0.04 for early M and solar-type stars, respectively, larger by 1.62+-0.22 and 1.39+-0.18 times compared to field stars of similar masses. The excess is produced mostly by pairs closer than 100 au. At separations from 100 to 10^4 au, the separation distribution and companion fraction resemble those of solar-type stars in the field. However, unlike in the field, we see a relative deficit of equal-mass binaries at separations of ~500 au, compared to smaller and larger separations. The distribution of q depends on the separation, with a preference of larger q and a larger fraction of twins with q>0.95 at smaller separations. The binary population of Upper Scorpius differs from binaries in the field in several ways and suggests that binary statistics is not universal.
description: Accepted for publication in AJ. 18 pages, 19 Figures, 9 tables (incl. 4 electronic tables)
title: Corporate Social Responsibility Practices in the Nigerian Public Sector
Creators: name: Mohammed, Abbas Adamu
Publisher: name: University of Plymouth
Year: 2024
Subjects: subject: CSR, ESG, Sustainability
subject: PhD

description: This study examines Corporate Social Responsibility (CSR) practices in Nigerian public sector organisations using a comprehensive mixed-methods approach. The data collection process involved analysing 185 organisation-year observations from annual reports spanning 2011–2020, as well as questionnaires distributed to key stakeholders and interviews with senior executives from various organisations. The analysis utilised a multi-pronged strategy, including quantitative techniques such as regression analysis to explore the relationship between CSR practices and corporate governance mechanisms and qualitative methods such as narrative analysis and thematic coding to gain insights from survey responses and interviews. The findings indicate that CSR practices in the Nigerian public sector are moving in a positive direction. Organisations demonstrated commitment to CSR activities, including community development, education, environmental conservation, and philanthropy. Survey results showed that 83% of organisations engaged in CSR, driven by community acceptance and moral obligation. Additionally, 84% of organisations complied with regulatory frameworks, and 79% aligned their CSR policies with national or international standards. The analysis also found a significant positive relationship between CSR practices and factors such as larger board sizes, greater board independence, the presence of women on the board, and CEOs with longer tenures, higher educational qualifications, and international exposure. By triangulating these findings, it is clear that organisations have a strong commitment to giving back through various CSR initiatives, such as humanitarian assistance, youth empowerment, and educational programmes. Despite challenges such as budgetary constraints and weak accountability frameworks, organisations recognise the perceived benefits of CSR, including increased public confidence, improved stakeholder perceptions, enhanced organisational reputation, trust-building, community engagement, and empowering marginalised communities through education. The insights gained from this study conducted in an emerging economy namely, Nigeria, provide a new understanding of CSR practices in public-sector organisations. They also highlight the proactive approach of public sector organisations towards responsible practices. Consequently, the implications of this research extend beyond national boundaries, encouraging diverse and dedicated leadership to enhance CSR efforts and create lasting social impact. Future studies could explore comparative analysis between the public and private sectors or different countries, as well as sector-specific impact assessments.
MOESM1 of Polypharmacy in older patients: identifying the need for support by a community pharmacist
Creators: name: Jean-Baptiste Beuscart
name: Petit, Ségolène
name: Gautier, Sophie
name: Wierre, Patrick
name: Balcaen, Thibaut
name: Jean-Marc Lefebvre
name: Kambia, Nicolas
name: Bertoux, Elisabeth
name: Mascaut, Daniel
name: Barthélémy, Christine
name: Cuny, Damien
name: Puisieux, François
name: Décaudin, Bertrand
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Additional file 1. Topic guide for the management of personal treatment and side-effects.
Network evasion detection with Bi-LSTM model
Creators: name: Chen, Kehua
name: Jia, Jingping
Publisher: name: arXiv
Year: 2025
Subjects: subject: Cryptography and Security (cs.CR)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Network evasion detection aims to distinguish whether the network flow comes from link layer exists network evasion threat, which is a means to disguise the data traffic on detection system by confusing the signature. Since the previous research works has all sorts of frauds, we propose a architecture with deep learning network to handle this problem. In this paper, we extract the critical information as key features from data frame and also specifically propose to use bidirectional long short-term memory (Bi-LSTM) neural network which shows an outstanding performance to trace the serial information, to encode both the past and future trait on the network flows. Furthermore we introduce a classifier named Softmax at the bottom of Bi-LSTM, holding a character to select the correct class. All experiments results shows that we can achieve a significant performance with a deep Bi-LSTM in network evasion detection and it's average accuracy reaches 96.1%.
description: 4 pages,5 figures
Turbulent-like fluctuations in quasistatic flow of granular media
Creators: name: Radjai, F.
name: Roux, S.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We analyze particle velocity fluctuations in a simulated granular system subjected to homogeneous quasistatic shearing. We show that these fluctuations share the following scaling characteristics of fluid turbulence in spite of their different physical origins: 1) Scale-dependent probability distribution with non-Guassian broadening at small time scales; 2) Power-law spectrum, reflecting long-range correlations and the self-affine nature of the fluctuations; 3) Superdiffusion with respect to the mean background flow.