cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Li-Ion cell-to-cell active balancing battery management system for 2nd life applications
Creators: name: Räber, Manuel
name: Ramirez Acosta, Andres Fernando
name: Heinzelmann, Andreas
name: Zoller, Michael
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2017
Subjects: 621.3: Elektro-, Kommunikations-, Steuerungs- und Regelungstechnik

description: The institute of energy systems has developed an active balancing battery management system (BMS) prototype for up to 8 cells in series. It is capable of equalizing charge imbalances in 7SxP (Li-NMC, Li-NCA) or 8SxP (LiFePO4) battery systems.
A versatile cell-to-cell topology has been implemented, based on a multi-winding transformer which is operated either in buck/boost-mode or flyback-mode.
Behinderte, Menschen mit besonderen Bedürfnissen oder eher Menschen mit einer Behinderung? : kritische Auseinandersetzung mit Begriffen zur Bezeichnung von Behinderung bezogen auf den medizinisch-therapeutischen Bereich im deutschsprachigen Raum
Creators: name: Holzer, Sonja
name: Zurkirchen, Marion
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2019
Subjects: Begriff Behinderung
Menschen mit einer Behinderung
Menschen mit einer Beeinträchtigung
Invalide
Menschen mit besonderen Bedürfnissen
Menschen mit Handicap
Medizinisch-therapeutische Berufe
Modelle von Behinderung
Kategorie Behinderung
401.4: Terminologie, Diskursanalyse, Pragmatik
610: Medizin und Gesundheit

description: Hintergrund: Für die Bezeichnung von  werden unterschiedliche Begriffe häufig als vermeintliche Synonyme verwendet. Personen aus dem medizinisch-therapeutischen Bereich stehen immer wieder vor der Frage, wie Angehörige dieser Personengruppe bezeichnet werden sollten.
Fragestellung: Welche deutschen Begriffe eignen sich für Berufsleute aus dem medizinisch-therapeutischen Bereich, um mit einer Behinderung lebende Menschen zu bezeichnen?

Methode: Durch eine Dokumentenanalyse wurden verschiedene Bezeichnungen für  gesammelt.
Die gefundenen Begriffe wurden unter Berücksichtigung historischer Aspekte und verschiedener Denkweisen zu Behinderung analysiert und den unterschiedlichen Modellen von Behinderung zugeordnet. Aus dieser Zuordnung wurden schliesslich Empfehlungen für die medizinisch-therapeutische Praxis abgegeben.

Relevante Ergebnisse: Innerhalb der verschiedenen Bezeichnungen für  können inhaltliche Unterschiede ausgemacht werden. Im medizinisch-therapeutischen Bereich wurde diesen Unterschieden bisher zu wenig Beachtung geschenkt.

Schlussfolgerung: Für die medizinisch-therapeutische Praxis scheint die klare Unterscheidung der Bezeichnungen Mensch mit einer Beeinträchtigung und Mensch mit einer Behinderung besonders relevant zu sein. Zudem sollten aus Sicht der Autorinnen die Begriffe Menschen mit besonderen Bedürfnissen und Menschen mit Handicap mit Bedacht gewählt werden.
Cognitive impairment and medication adherence in stroke
Creators: name: Rohde, Daniela
Publisher: name: Royal College of Surgeons in Ireland
Year: 2020
Subjects: Medicine

description: Aim The overarching aim of this thesis was to explore the bidirectional association between adherence to secondary prevention medications and cognitive impairment in stroke survivors. A secondary aim was to provide an updated account of the longer-term outcomes of cognitive impairment post-stroke. Methods and results Five interrelated studies were conducted to address these aims. Study 1 explored the association between cognitive impairment and cardiovascular medication use in an Irish sample of the general population aged 50+, finding no evidence of an independent association between use of cardiovascular medications and cognitive impairment. Study 2 systematically reviewed the existing literature on the association between cognitive impairment and medication adherence in stroke survivors, and found no significant association when all included studies were pooled, although heterogeneity was significant and the overall evidence quality poor. Studies 3, 4 and 5 were based on a 5-year follow-up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) cohort study. Study 3 explored the impact of cognitive impairment on subsequent medication adherence, as well as the impact of medication non-adherence on later cognitive impairment. While this study found no statistically significant associations between cognitive impairment and medication adherence, stroke survivors with cognitive impairment were significantly more likely to receive help with medication taking. Study 4 considered the impact of cognitive impairment on outcomes, finding that cognitive impairment at 6 months post-stroke was associated with significantly increased risk of mortality, further cognitive decline, worse quality of life, lower levels of independence, and increased likelihood of depressive symptoms at 5 years. Study 5 explored family caregiver psychological wellbeing, and revealed that family caregivers of stroke survivors with cognitive decline were significantly more likely to experience anxiety and depression. Conclusion Taken together, the findings from this thesis do not indicate an association between cognitive impairment and medication adherence in stroke survivors. However, a number of factors could account for this lack of consistent association, including the moderating effect of help received with medication taking, as well as the range of definitions and assessments of non-adherence and cognitive function, which make it difficult to draw comparisons across studies. Given the prevalence of both of these phenomena in stroke survivors, and their associations with poorer outcomes, the design of effective interventions to address medication non-adherence and to reduce the burden of cognitive impairment post-stroke is paramount.
Computing asymptotic invariants with the Ricci tensor on asymptotically flat and hyperbolic manifolds
Creators: name: Herzlich, Marc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We prove in a simple and coordinate-free way the equivalence bteween the classical definitions of the mass or the center of mass of an asymptotically flat manifold and their alternative definitions depending on the Ricci tensor and conformal Killing fields. This enables us to prove an analogous statement in the asymptotically hyperbolic case.
description: Accepted for publication in Annales Henri Poincar{\'e}
Open, FAIR, and used: toxicology in the next 10 years
Creators: name: Willighagen, Egon
Publisher: name: Zenodo
Year: 2022
Subjects: open science
toxicology
FAIR
quality

description: Keynote talk at OpenTox Virtual Conference 2022: "For toxicology to take advantage of modern science, and for risk assessment to meet societal needs, it needs to step up its open science practices. Here, I argue that FAIR and sustainability should not distract us (too much) from the bigger picture. And that with the risk of preaching to the choir; after all, to me, one key selling point of OpenTox has been their argument for open licensing. This presentation sketches a vision of where toxicology is heading (or should be) in the next 10 years, starting with open science achievements, a series of past research projects, and designs of running projects. The role of open data, open source, and open standards will be illustrated with activities in EU NanoSafetyCluster projects and the ELIXIR Toxicology Community."
Additional file 10: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson’s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: GEO accession numbers of Parkinson’s disease studies included in the analysis. (PDF 348 kb)
Formation and evolution of the two 4/3 resonant giants planets in HD 200946
Creators: name: Santos, M. Tadeu dos
name: Correa-Otto, J. A.
name: Michtchenko, T. A.
name: Ferraz-Mello, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: It has been suggested that HD 200964 is the first exoplanetary system with two Jovian planets evolving in the 4/3 mean- motion resonance. Previous scenarios to simulate the formation of two giant planets in the stable 4/3 resonance configuration have failed. Moreover, the orbital parameters available in the literature point out an unstable configuration of the planetary pair. The purpose of this paper is i) to determine the orbits of the planets from the RV measurements and update the value of the stellar mass (1.57 M), ii) to analyse the stability of the planetary evolution in the vicinity and inside the 4/3 MMR, and iii) to elaborate a possible scenario for the formation of systems in the 4/3 MMR. The results of the formation simulations are able to very closely reproduce the 4/3 resonant dynamics of the best-fit config- uration obtained in this paper. Moreover, the confidence interval of the fit matches well with the very narrow stable region of the 4/3 mean-motion resonance. The formation process of the HD 200964 system is very sensitive to the planetary masses and protoplanetary disk parameters. Only a thin, flat disk allows the embryo-sized planets to reach the 4/3 resonant configuration. The stable evolution of the resonant planets is also sensitive to the mass of the central star, because of overlapping high-order resonances inside the 4/3 resonance. Regardless of the very narrow domain of stable motion, the confidence interval of our fit closely matches the stability area.
Spatial distribution of two symmetric four-wave mixing signals induced by Gaussian beams
Creators: name: da Motta, Mateus R. L.
name: de Almeida, Alexandre A. C.
name: Vianna, Sandra S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present a theoretical analysis of the spatial shape of two symmetric signals of degenerate four-wave mixing induced by Gaussian beams in a thin sample of two-level atoms. Our calculations take into account the full spatial and spectral dependencies of the relevant nonlinear susceptibilities that govern the two processes. This reveals two interesting effects. The first one is that the total power of incident beams affects the transverse profile of the four-wave mixing signals at the medium exit and their free propagation. The second one is the influence of the spectral characteristics of the medium on the longitudinal profile of both generated signals upon free propagation. We argue that the first effect can be seen as the saturation of the medium in regions of higher intensity, while the second can be understood as the result of a nonlinear contribution to the refractive index inside the atomic medium. These effects can be symmetric between the two signals, with asymmetries induced by different detunings from resonance of the incident fields.
Model testing, R Code and, RAmazon Dataset from Did pre-Columbian populations of the Amazonian biome reach carrying capacity during the Late Holocene?
Creators: name: Arroyo-Kalin, Manuel
name: Riris, Philip
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: The increasingly better-known archaeological record of the Amazon basin, the Orinoco basin and the Guianas both questions the long-standing premise of a pristine tropical rainforest environment and also provides evidence for major biome-scale cultural and technological transitions prior to European colonization. Associated changes in pre-Columbian human population size and density, however, are poorly known and often estimated on the basis of unreliable assumptions and guesswork. Drawing on recent developments in the aggregate analysis of large radiocarbon databases, here we present and examine different proxies for relative population change between 1050 BC and AD 1500 within this broad region. By using a robust model testing approach, our analyses document that the growth of pre-Columbian human population over the 1,700 years prior to European colonization adheres to a logistic model of demographic growth. This suggests that, at an aggregate level, these pre-Columbian populations had likely reached carrying capacity (however high) before the onset of European colonization. Our analyses also demonstrate that this aggregate scenario shows considerable variability when projected geographically, which bears on our overall understanding of the resilience of past human food procurement strategies. Lastly, our results provide important insights into pre-Columbian demographic trends and offer novel perspectives on demic expansions, language diversification and subsistence intensification in the Amazonian biome during the late Holocene.This article is part of the theme issue ‘Cross-disciplinary approaches to prehistoric demography’.
Additional file 6: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson’s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Virology

description: Heatmap of differential gene expression in Parkinson’s disease studies. (PDF 454 kb)
Supplementary information and figures from Demographic estimates from the Palaeolithic–Mesolithic boundary in Scandinavia: comparative benchmarks and novel insights
Creators: name: Lundström, Victor
name: Peters, Robin
name: Riede, Felix
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Prehistoric demography has recently risen to prominence as a potentially explanatory variable for episodes of cultural change as documented in the archaeological and ethnographic record. While this has resulted in a veritable boom in methodological developments seeking to address temporal changes in the relative size of prehistoric populations, little work has focused on the manner in which population dynamics manifests across a spatial dimension. Most recently, the so-called Cologne Protocol has led the way in this field. However, strict requirements of raw-material exchange data as analytical inputs have prevented further applications of the protocol to regions outside of continental Europe. We apply an adjusted approach of the protocol that makes it case transferable to other parts of the world, while demonstrating its utility by providing comparative benchmarks of previous research on the Late Glacial Final Palaeolithic of southern Scandinavia, and novel insights from the early Holocene pioneer colonization of coastal Norway. Although our results (re)demonstrate that population levels were low and occasionally hovered just above potential viability thresholds, we consider the estimates on population densities as having a much stronger and, occasionally, more negative effect on episodes of cultural change as testified in the regional archaeological records.This article is part of the theme issue ‘Cross-disciplinary approaches to prehistoric demography’.
Jung, psychisch krank und invalidisiert
Creators: name: Baer, Niklas
name: Juvalta, Sibylle
name: Altwicker-Hámori, Szilvia
name: Frick, Ulrich
name: Rüesch, Peter
Publisher: name: Bundesamt für Sozialversicherungen
Year: 2016
Subjects: IV-Renten
Psychische Gesundheit
Jugendliche/-r
305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)
616.89: Psychische Störungen, klinische Psychologie und Psychiatrie

description: Die Zahl der jungen psychisch kranken IV-Rentnerinnen und -Rentner hat in den letzten 20 Jahren stetig zugenommen. Die vorliegende Untersuchung weist auf Mängel im Bildungs-, Behandlungs- und IV-System hin und wirft die Frage auf, ob eine relevante Minderheit von jungen Menschen nicht zu früh berentet wurde.
Additional file 1: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinsonâ  s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: List of Reactome pathways identified as significant in human and animal studies by gene set enrichment analysis. (PDF 70Â kb)
Generación de anticuerpos policlonales anti desintegrinas
Creators: name: Flores Castelán, Mariana
Publisher: name: Zenodo
Year: 2022
Subjects: integrinas; anticuerpos policlonales; células tumorales; desintegrinas; tratamiento de cáncer

description: Resumen Las integrinas son receptores heterodiméricos transmembranales conformados por dos subunidades, alfa (α) y beta (β), que se encargan de regular las interacciones célula-célula y célula-matriz extracelular. Además, están involucradas en la hemostasia, proliferación y migración celular, angiogénesis, actividades inflamatorias, organización celular y transducción de señales. Asimismo, se ha demostrado que las integrinas cuentan con una estrecha relación con la oncogénesis, ya que su función de transmisión de señales moleculares facilita la formación, proliferación y migración de células tumorales. No obstante, existen moléculas capaces de inhibir la actividad de dichos receptores, denominas desintegrinas. Estas son proteínas no enzimáticas y no tóxicas que derivan de metaloproteasas de veneno de serpiente (SVMPs). Las desintegrinas han sido aisladas y purificadas para poder desarrollar fármacos que puedan ser de utilidad en los tratamientos de cáncer. Sin embargo, los métodos de aislamiento de desintegrinas han demostrado ser lentas y, en ciertas ocasiones, inespecíficas. Por ello, se ha planteado la idea de generar anticuerpos policlonales anti desintegrinas a través de inmunizaciones en animales, para que puedan acoplarse a una resina y formar una cromatografía de inmunoafinidad que agilice la purificación de las desintegrinas de una forma eficiente [1-3].
description: {"references": ["Arruda Macedo, J., Fox, J., & Souza Castro, M. (2015). Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy. Current Protein & Peptide Science, 16(6), 532-548. https://doi.org/10.2174/1389203716666150515125002", "S\u00e1nchez, E. E. (2004). Desintegrinas en Veneno de Serpientes: Un nuevo enfoque en el tratamiento de las enfermedades Cardiovasculares, C\u00e1ncer, Di\u00e1betes. Revista de la Facultad de Medicina, 27(1), 10-14", "Lazarovici, P., Marcinkiewicz, C., & Lelkes, P. I. (2019). From Snake Venom's Disintegrins and C-Type Lectins to Anti-Platelet Drugs. Toxins, 11(5), 303. https://doi.org/10.3390/toxins11050303"]}
Die Rolle der Berufsberatungs- und Informationszentren im Berufswahlprozess von unbegleiteten minderjährigen Personen im Asylbereich : eine qualitative Untersuchung am Beispiel des Kantons Bern
Creators: name: Mazel, Jarmila
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2017
Subjects: 305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)
331: Arbeitsökonomie

description: Die Zahl der unbegleiteten minderjährigen Personen im Asylbereich (UMA) ist in den letzten drei Jahren markant angestiegen. Die Mehrheit ist in einem Alter, in dem die Berufswahl und Integration in den Arbeitsmarkt zentrale Themen sind. Es ist davon auszugehen, dass die öffentlichen Berufs-, Studien- und Laufbahnberatungsstellen in ihrer Arbeit vermehrt auf diese Zielgruppe treffen werden. Die vorliegende Arbeit beschäftigt sich mit der Frage, welche Rolle die Berufsberatungs- und Informationszentren (BIZ) im Berufswahlprozess von UMA spielen sollen. Die Zielsetzung besteht darin, die Akteure im Kontext der UMA zu klären, Erkenntnisse zum Berufswahlprozess von UMA zu gewinnen sowie aus Theorie und Praxis mögliche Handlungsvorschläge für die BIZ abzuleiten. Die Fragestellung wurde am Beispiel des Kantons Bern bearbeitet. Um Antworten hinsichtlich der Fragestellung und Zielsetzung zu erhalten, wurden theoretische Grundlagen konsultiert und die Praxis untersucht. Lehrpersonen, die UMA in einem Brückenangebot mit Schwerpunkt Integration unterrichten, haben im Berufswahlprozess von UMA eine Schlüsselrolle. Mit vier dieser Lehrpersonen wurden leitfadengestützte Interviews durchgeführt. Das transkribierte Material wurde mittels einer qualitativen Inhaltsanalyse nach Lamnek ausgewertet.
Additional file 5: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinsonâ  s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Principal component analysis of studies based on differential expression signatures, principal components 1 and 2. (PDF 110Â kb)
Sub-network Discovery and Soft-masking for Continual Learning of Mixed Tasks
Creators: name: Ke, Zixuan
name: Liu, Bing
name: Xiong, Wenhan
name: Celikyilmaz, Asli
name: Li, Haoran
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Continual learning (CL) has two main objectives: preventing catastrophic forgetting (CF) and encouraging knowledge transfer (KT). The existing literature mainly focused on overcoming CF. Some work has also been done on KT when the tasks are similar. To our knowledge, only one method has been proposed to learn a sequence of mixed tasks. However, these techniques still suffer from CF and/or limited KT. This paper proposes a new CL method to achieve both. It overcomes CF by isolating the knowledge of each task via discovering a subnetwork for it. A soft-masking mechanism is also proposed to preserve the previous knowledge and to enable the new task to leverage the past knowledge to achieve KT. Experiments using classification, generation, information extraction, and their mixture (i.e., heterogeneous tasks) show that the proposed method consistently outperforms strong baselines.
description: https://github.com/ZixuanKe/PyContinual
Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery
Creators: name: Maruoka, Kiyotaka
name: Koseki, Yoshitaka
name: Dao, Anh Thi Ngoc
name: Suzuki, Ryuju
name: Batbayar, Anudari
name: Sugeno, Nagaki
name: Umezawa, Hirohito
name: Kasai, Hitoshi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-CN-PPT nano-prodrugs). GA-CN-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-CN-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.
Additional file 3: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinsonâ  s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Plots of average concordance against sample size for gene expression and biological pathway enrichment. (PDF 64Â kb)
Solving bandwidth-guaranteed routing problem using routing data
Creators: name: Thanh, Cao Thai Phuong
name: Nam, Ha Hai
name: Hung, Tran Cong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper introduces a traffic engineering routing algorithm that aims to accept as many routing demands as possible on the condition that a certain amount of bandwidth resource is reserved for each accepted demand. The novel idea is to select routes based on not only network states but also information derived from routing data such as probabilities of the ingress egress pairs and usage frequencies of the links. Experiments with respect to acceptance ratio and computation time have been conducted against various test sets. Results indicate that the proposed algorithm has better performance than the existing popular algorithms including Minimum Interference Routing Algorithm (MIRA) and Random Race based Algorithm for Traffic Engineering (RRATE).
description: published in The International Journal of Computer Networks & Communications (IJCNC), vol. 6, no. 6
G10: Enabling An Efficient Unified GPU Memory and Storage Architecture with Smart Tensor Migrations
Creators: name: Zhang, Haoyang
name: Zhou, Yirui Eric
name: Xue, Yuqi
name: Liu, Yiqi
name: Huang, Jian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Hardware Architecture (cs.AR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: To break the GPU memory wall for scaling deep learning workloads, a variety of architecture and system techniques have been proposed recently. Their typical approaches include memory extension with flash memory and direct storage access. However, these techniques still suffer from suboptimal performance and introduce complexity to the GPU memory management, making them hard to meet the scalability requirement of deep learning workloads today. In this paper, we present a unified GPU memory and storage architecture named G10 driven by the fact that the tensor behaviors of deep learning workloads are highly predictable. G10 integrates the host memory, GPU memory, and flash memory into a unified memory space, to scale the GPU memory capacity while enabling transparent data migrations. Based on this unified GPU memory and storage architecture, G10 utilizes compiler techniques to characterize the tensor behaviors in deep learning workloads. Therefore, it can schedule data migrations in advance by considering the available bandwidth of flash memory and host memory. The cooperative mechanism between deep learning compilers and the unified memory architecture enables G10 to hide data transfer overheads in a transparent manner. We implement G10 based on an open-source GPU simulator. Our experiments demonstrate that G10 outperforms state-of-the-art GPU memory solutions by up to 1.75$\times$, without code modifications to deep learning workloads. With the smart data migration mechanism, G10 can reach 90.3\% of the performance of the ideal case assuming unlimited GPU memory.
description: This paper is accepted at The 56th IEEE/ACM International Symposium on Microarchitecture (MICRO'23). *Co-primary authors
Universal low-temperature Ohmic contacts for quantum transport in transition metal dichalcogenides
Creators: name: Xu, Shuigang
name: Wu, Zefei
name: Lu, Huanhuan
name: Han, Yu
name: Long, Gen
name: Chen, Xiaolong
name: Han, Tianyi
name: Ye, Weiguang
name: Wu, Yingying
name: Lin, Jiangxiazi
name: Shen, Junying
name: Cai, Yuan
name: He, Yuheng
name: Zhang, Fan
name: Lortz, Rolf
name: Cheng, Chun
name: Wang, Ning
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Low carrier mobility and high electrical contact resistance are two major obstacles prohibiting explorations of quantum transport in TMDCs. Here, we demonstrate an effective method to establish low-temperature Ohmic contacts in boron nitride encapsulated TMDC devices based on selective etching and conventional electron-beam evaporation of metal electrodes. This method works for most extensively studied TMDCs in recent years, including MoS2, MoSe2, WSe2, WS2, and 2H-MoTe2. Low electrical contact resistance is achieved at 2 K. All of the few-layer TMDC devices studied show excellent performance with remarkably improved field-effect mobilities ranging from 2300 cm2/V s to 16000 cm2/V s, as verified by the high carrier mobilities extracted from Hall effect measurements. Moreover, both high-mobility n-type and p-type TMDC channels can be realized by simply using appropriate contact metals. Prominent Shubnikov-de Haas oscillations have been observed and investigated in these high-quality TMDC devices.
description: The methods have been applied to p-type WSe2 and other TMDC based devices. Supplementary information is included
Synthesis, crystal structure, computational, and molecular docking studies of bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide tri hydrate
Creators: name: Matheswari, P. Pon
name: Asha, Radhakrishnan Nandini
name: Jeyamalar, J. Ilavarasi
name: Grace, P. Selvarathy
name: Schollmeyer, Dieter
name: Nayagam, B. Ravindran Durai
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Recently synthesized crystal of Bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide trihydrate (PD1Br) crystallizes in the monoclinic space group P21/c. The piperidine ring as a whole adopted chair conformation. Hirshfeld surface technique is useful for determining molecular nature and visualizing intermolecular relations in crystal structures. The molecular configuration, frontier theory of orbitals, and thermodynamic character of the label molecule were examined via density functional theory (DFT) computations make use of the B3LYP method with the 6-311++G (d,p) basis set. On the report of molecular docking investigation, the chemical binds efficiently to protein, resulting in a significant anticancer property.
Essential elements regulating HDAC8 inhibition: a classification based structural analysis and enzyme-inhibitor interaction study of hydroxamate based HDAC8 inhibitors
Creators: name: Suvankar Banerjee
name: Sk. Abdul Amin
name: Nilanjan Adhikari
name: Jha, Tarun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 60506 Virology

description: Histone deacetylase 8 (HDAC8) expressions are correlated with a variety of cancer and tumor conditions. For the pathophysiological contributions of HDAC8, it is classified as an important target for cancer research. The hydroxamate derivatives are identified as more efficient HDAC8 inhibitors. However, strong chelating properties of hydroxamate group with the catalytic zinc ion of HDAC8 resulted in some demerits. Hence, in this current study, classification based chemoinformatic approaches including Bayesian modeling and recursive partitioning studies were conducted on a large and diverse set of 607 hydroxamates having less, very poor to high HDAC8 inhibitory properties. The main motto of this study is to identify and analyze the pivotal structural features of the cap and linker moieties required to obtain better HDAC8 inhibition. Moreover, a scrutiny of the HDAC8 crystal structure bound inhibitors was performed to correlate enzyme-inhibitor interactions with important molecular features resulted from these two classification-based models. The approach may be used to design novel HDAC8 inhibitors. Communicated by Ramaswamy Sarma
Wer ist Opfer, wer Täter, wenn es um Gewalt bei jugendlichen Paaren geht?
Creators: name: Baier, Dirk
name: Baur, Nicole Anja
Publisher: name: AvenirSocial
Year: 2017
Subjects: Gewalt
Paar
Junge Erwachsene
Monitoring
303: Soziale Prozesse
305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)

description: Eine Befragung unter Jugendlichen zeigt, dass verschiedene Formen der Gewalt in Paarbeziehungen z. T. weit verbreitet sind und dass sich Jungen und Mädchen bei einigen Formen kaum unterscheiden. Sind Jugendliche heute unfähig, gewaltlose Beziehungen zu führen?
Central limit theorem for the modulus of continuity of averages of observables on transversal families of piecewise expanding unimodal maps
Creators: name: de Lima, Amanda
name: Smania, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37C30, 37C40, 37E05, 37A05

description: We prove that the Newton quotient of the average R(t) of a lipschitzian function (with non vanishing variation) with respect to the SRB measure on a transversal family f_t of piecewise expanding unimodal maps, after an appropriated normalization, converges in distribution to the normal distribution.
Molecular docking, X-ray crystallography, Hirshfeld surface and computational studies of N-((2,3-dichlorophenyl)(ethoxy)methyl)-2-methoxy-4-nitrobenzenamine
Creators: name: Kumar, Sunil
name: Choudhary, Mukesh
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: In this study, we report the synthesis, characterization and theoretical study of an organic compound namely N-((2,3-dichlorophenyl)(ethoxy)methyl)-2-methoxy-4-nitrobenzenamine (L) as potential drug candidate against SARS-CoV-2 main protease. Structural and Hirshfeld surface analysis was carried out on the organic compound (L). The potential application was also assessed through molecular docking and 3-D visualizations of intermolecular interactions with two very important crucial proteins of SARS-CoV-2 (MPro-7C6U & 7C6S). Molecular docking calculations exhibited high binding energy and inhibition constant of −7.4 kcal/mol and 2.413 µM with SARS-CoV-2 MPro. Besides this, an ADMET prediction was also studied. This study provides an alternative and viable therapeutic agent for SARS-CoV-2 virus.
Matrix pencils with the numerical range equal to the whole complex plane
Creators: name: Koval, Vadym
name: Pagacz, Patryk
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 15A22, 15A60

description: The main purpose of this article is to show that the numerical range of a linear pencil $λA + B$ is equal to $\mathbb{C}$ if and only if $0$ belongs to the convex hull of the joint numerical range of $A$ and $B$. We also prove that if the numerical range of a linear pencil $λA + B$ is equal to $\mathbb{C}$ and $A + A^*, B + B^* \geq 0$, then $A$ and $B$ have a common isotropic vector. Moreover, we improve the classical result which describes Hermitian linear pencils.
description: 9
Effect of bromine atom on the different tautomeric forms of microhydrated 5-bromouracil, in the DNA:RNA microhelix and in the interaction with human proteins
Creators: name: M. Alcolea Palafox
name: S. M. Chalanchi
name: J. Isasi
name: R. Premkumar
name: A. Milton Franklin Benial
name: V. K. Rastogi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: This study focuses on the effects of the bromine atom on the molecular structure parameters in the main tautomeric forms of 5-bromouracil (5BrU), and as well, its effect on hydration and on the Watson-Crick (WC) pairs as compared to uracil molecule. The influence of the bromine atom was studied in several environments. The hydration effect on the molecular structure and energies of the main tautomeric forms of 5BrU was analyzed by considering a variable number of water molecules in explicit form up to 30 to simulate the first and second hydration shells. The ‘mutagenic’ 2-hydroxy-4-oxo (U2) enol tautomer of 5BrU, but not of uracil, was absolutely favored over the keto form in clusters with more than 20 water molecules. For all calculations, B3LYP and M06-2X Methods were used. The effect of the bromine atom when it was inserted into the natural and reverse WC pairs uridine-adenosine was also determined, and counterpoise (CP) corrected interaction energies were calculated. The effect of the bromine atom was analyzed in several DNA:RNA hybrid microhelices. Different backbone and helical parameters were calculated and compared. The bromine atom destabilizes its base pair, with a remarkable increase in the rise parameter (Dz) corresponding to the microhelix, and to a slight increase in the diameter (d). Molecular docking calculations were also carried out with 5BrU for targeted proteins associated with diabetes, hepatocellular carcinoma and breast and lung cancers. The molecular docking analysis confirms that the 5BrU molecule may play an important role as a promising inhibitor against breast cancer. Communicated by Ramaswamy H. Sarma
Additional file 12: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinsonâ  s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology

description: Significance thresholds of concordance for different subgroup sizes. (PDF 121Â kb)
Nodal vacancy bound states and resonances in three-dimensional Weyl semimetals
Creators: name: Pires, J. P. Santos
name: João, S. M.
name: Ferreira, Aires
name: Amorim, B.
name: Lopes, J. M. Viana Parente
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The electronic structure of a cubic $\mathcal{T}$-symmetric Weyl semimetal is analysed in the presence of atomic-sized vacancy defects. Isolated vacancies are shown to generate nodal bound states with $r^{\scriptscriptstyle -2}$ asymptotic tails, even when immersed in a weakly disordered environment. These states show up as a significantly enhanced nodal density of states which, as the concentration of defects is increased, reshapes into a nodal peak that is broadened by inter-vacancy hybridisation into a comb of satellite resonances at finite energies. Our results establish point defects as a crucial source of elastic scattering that leads to nontrivial modifications in the electronic structure of Weyl semimetals.
description: 11 pages, 10 figures. Title Change and Text Adaptation Relative to V3
Additional file 9: of Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson’s disease: a comparison of 33 human and animal studies
Creators: name: Oerton, Erin
name: Bender, Andreas
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Heatmap of differential gene expression in Parkinson’s disease, Alzheimer’s disease, and brain tumor studies. (PDF 348 kb)
Spin Connection and Renormalization of Teleparallel Action
Creators: name: Krššák, Martin
name: Pereira, J. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In general relativity, inertia and gravitation are both included in the Levi-Civita connection. As a consequence, the gravitational action, as well as the corresponding energy-momentum density, are in general contaminated by spurious contributions coming from inertial effects. In teleparallel gravity, on the other hand, because the spin connection represents inertial effects only, it is possible to separate inertia from gravitation. Relying on this property, it is shown that to each tetrad there is naturally associated a spin connection that locally removes the inertial effects from the action. The use of the appropriate spin connection can be viewed as a renormalization process in the sense that the computation of energy and momentum naturally yields the physically relevant values. A self-consistent method for solving field equations and determining the appropriate spin connection is presented.
description: v2: 13 pages, minor corrections, new section about solving the field equations included
Ortsbestimmung von Objekten im Innenbereich über Echtzeit-Lokalisierung
Creators: name: Rüst, Andreas
Publisher: name: Swiss Professional Media
Year: 2015
Subjects: 802.15.4-UWB
Positioning
Location
621.3: Elektro-, Kommunikations-, Steuerungs- und Regelungstechnik

description: Im Aussenbereich erfolgt die Ortsbestimmung von Objekten heute meist über satellitengestützte Systeme wie GPS. Im Innern von Gebäuden gelingt dies aber auf Grund der Signaldämpfung nur sehr eingeschränkt. Dieser Artikel beschreibt eine im Innenbereich anwendbare Echtzeit-Lokalisierung, die auf gemessenen Laufzeiten von IEEE 802.15.4-Ultrawideband-Signalen (UWB) beruht.
The role of investor attention in global asset price variation during the invasion of Ukraine
Creators: name: Halousková, Martina
name: Stašek, Daniel
name: Horváth, Matúš
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: We study the impact of event-specific attention indices -- based on Google Trends -- in predictive price variation models before and during the Russian invasion of Ukraine in February 2022. We extend our analyses to the importance of geographical proximity and economic openness to Russia within 51 global equity markets. Our results demonstrate that 36 countries show significant attention to the conflict at the onset of and during the invasion, which helps predict volatility. We find that the impact of attention is more significant in countries with a higher degree of economic openness to Russia and those nearer to it.
description: This paper includes 17 pages, 3 figures and 8 tables
Wie gut erfüllen Amphibientunnel und -leitsysteme ihren Zweck? : Akzeptanz- und Erfolgskontrolle unterschiedlicher Anlagetypen in der Schweiz
Creators: name: Brenneisen, Stephan
name: Szallies, Alexander
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2017
Subjects: Amphibientunnel
Naturschutz
Strasse
Erfolgskontrolle
333: Bodenwirtschaft und Ressourcen
380: Verkehr
500: Naturwissenschaften

description: Dieser Bericht beschreibt Ergebnisse einer Untersuchung wie gut Amphibientunnel und -leitsysteme in der Schweiz ihren Zweck erfüllen. Es wurde eine Akzeptanz- und Erfolgskontrolle unterschiedlicher Anlagetypen durchgeführt zur Nutzung durch Kröten und Frösche sowie deren langfristigen Populationsentwicklungen in den Untersuchungsgebieten. In verschiedenen Regionen der Schweiz sollten unterschiedliche Anlagetypen und Materialisierungen vergleichend geprüft werden, welche unterschiedliche „Epochen“ des Amphibienschutzes an Strassen (Anlagen über 30 Jahre alt) und Konstruktionsprinzipien repräsentieren. Begleitend untersucht wurden Fragen zum Unterhalt der Anlagen und deren möglichen Auswirkungen auf deren Funktionalität.
Darauf aufbauend werden Hinweise und Massnahmen für die Praxis sowie weiterführender Handlungs- und Forschungsbedarf aufgezeigt. Die Ergebnisse der Forschungsarbeiten dienen konkret der Ausarbeitung von Strassenverkehrsnormen sowie technischen Planungen im Bereich von Strassenprojekten mit Schutzanforderungen für Amphibien. Mit den Projektergebnissen können Aussage gemacht werden, ob die in der Regel teuren Anlagen ihr Geld wert sind und es lassen sich Empfehlungen bezüglich Unterhalt ableiten. Weiter erlaubt das Projekt Aussagen über Eigenschaften der Anlagen, welche helfen, Bau und Unterhalt in Zukunft zu optimieren.
Die Bahn bremst die Zersiedelung
Mehr Verkehr führt nicht in jedem Fall zu grösserer räumlicher Streuung.
Creators: name: Steinegger, Rolf
Publisher: name: Neue Zürcher Zeitung
Year: 2014
Subjects: Zersiedlung
Verkehrswachstum
Raumplanung
Schiene und Strasse
Öffentlicher Verkehr
380: Verkehr
711: Raumplanung (Städtebau)

description: Der öffentliche Verkehr auf der Schiene und die Raumplanung sind der Schlüssel zur Eindämmung der Zersiedelung - ohne dass der Wohlstand aufs Spiel gesetzt werden muss. Es gilt, die Verkehrsträger gemäss ihren Stärken einzusetzen.