cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cotinine versus questionnaire: early-life environmental tobacco smoke exposure and incident asthma
Creators: name: Carlsten, Christopher Russell
name: Dimich-Ward, Helen
name: DyBuncio, Anne
name: Becker, Allan B.
name: Chan-Yeung, Moira
Publisher: name: BioMed Central
Year: 2015

description: Background: The use of biomarkers has expanded considerably, as an alternative to questionnaire-based metrics of environmental tobacco smoke (ETS); few studies have assessed the affect of such alternative metrics on diverse respiratory outcomes in children, and we aimed to do so. Methods We evaluated various measures of birth-year ETS, in association with multiple respiratory endpoints early years of life, in the novel context of a birth cohort at high risk for asthma. We administered questionnaires to parents, both at the end of pregnancy and at one year of life, and measured cotinine in cord blood (CCot; in 275 children) and in urine (UCot; obtained at 12 months in 365 children), each by radioimmunoassay. Multiple logistic regression was used to assess the association of the various metrics with recurrent wheeze at age 2 and with bronchial hyperresponsiveness (BHR) and asthma at age 7. Results Self-reported 3rd trimester maternal smoking was associated with significantly increased risk for recurrent wheeze at age 2 (odds ratio 3.5 [95% confidence interval = 1.2,10.7]); the risks associated with CCot and 3rd trimester smoking in any family member were similar (OR 2.9 [1.2,7.0] and 2.6 [1.0,6.5], respectively). No metric of maternal smoking at 12 months appeared to significantly influence the risk of recurrent wheeze at age 2, and no metric of ETS at any time appeared to significantly influence risk of asthma or BHR at age 7. Conclusions Biomarker- and questionnaire-based assessment of ETS in early life lead to similar estimates of ETS-associated risk of recurrent wheeze and asthma.
Straightening of Superconducting HERA Dipoles for the Any-Light-Particle-Search Experiment ALPS II
Creators: name: Albrecht, Clemens
name: Barbanotti, Serena
name: Hintz, Heiko
name: Jensch, Kai
name: Klos, Ronald
name: Maschmann, Wolfgang
name: Sawlanski, Olaf
name: Stolper, Matthias
name: Trines, Dieter
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: cavity: optical
string: superconductivity
laser: beam
beam: width
DESY HERA Stor
dipole
magnet
ALPS
axion-like particles
bending magnet
sensitivity
performance
curvature
photon

description: At DESY the ALPS II experiment is being installed in the HERA tunnel to search for axion like particles (ALPs). A laser beam will be injected into a string of superconducting HERA dipole magnets, to produce ALPs. After passing a light tight wall, the ALPs can reconvert into photons in a second string of HERA dipoles.The sensitivity of the experiment will be increased by two mode-matched optical cavities before and behind the wall. The curvature of the magnets limits the performance of the optical resonators, Therefore the aperture for the optical resonators inside the HERA dipoles was increased by straightening the curved magnet yoke. The procedure of straightening the HERA dipoles is described in this report.
A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers
Creators: name: Günther, Oliver P.
name: Chen, Virginia
name: Cohen Freue, Gabriela V.
name: Balshaw, Robert F.
name: Tebbutt, Scott J.
name: Hollander, Zsuzsanna
name: Takhar, Mandeep
name: McMaster, W. R.
name: McManus, Bruce M.
name: Keown, Paul A.
name: Ng, Raymond T.
Publisher: name: BioMed Central
Year: 2015

description: Background: Biomarker panels derived separately from genomic and proteomic data and with a variety of computational methods have demonstrated promising classification performance in various diseases. An open question is how to create effective proteo-genomic panels. The framework of ensemble classifiers has been applied successfully in various analytical domains to combine classifiers so that the performance of the ensemble exceeds the performance of individual classifiers. Using blood-based diagnosis of acute renal allograft rejection as a case study, we address the following question in this paper: Can acute rejection classification performance be improved by combining individual genomic and proteomic classifiers in an ensemble? Results The first part of the paper presents a computational biomarker development pipeline for genomic and proteomic data. The pipeline begins with data acquisition (e.g., from bio-samples to microarray data), quality control, statistical analysis and mining of the data, and finally various forms of validation. The pipeline ensures that the various classifiers to be combined later in an ensemble are diverse and adequate for clinical use. Five mRNA genomic and five proteomic classifiers were developed independently using single time-point blood samples from 11 acute-rejection and 22 non-rejection renal transplant patients. The second part of the paper examines five ensembles ranging in size from two to 10 individual classifiers. Performance of ensembles is characterized by area under the curve (AUC), sensitivity, and specificity, as derived from the probability of acute rejection for individual classifiers in the ensemble in combination with one of two aggregation methods: (1) Average Probability or (2) Vote Threshold. One ensemble demonstrated superior performance and was able to improve sensitivity and AUC beyond the best values observed for any of the individual classifiers in the ensemble, while staying within the range of observed specificity. The Vote Threshold aggregation method achieved improved sensitivity for all 5 ensembles, but typically at the cost of decreased specificity. Conclusion Proteo-genomic biomarker ensemble classifiers show promise in the diagnosis of acute renal allograft rejection and can improve classification performance beyond that of individual genomic or proteomic classifiers alone. Validation of our results in an international multicenter study is currently underway.
Power and legitimacy during emergency politics: a democratic audit of responses to the Covid-19 crisis
Creators: name: Schmidt, Vivien
Publisher: name: Zenodo
Year: 2024
Subjects: legitimacy
democratic audit
emergency politics
Covid-19
fiscal rules
discursive institutionalism

description: EU and member-state responses to the Covid-19 pandemic involved emergency politics in a number of domains, including a) lockdowns, border closures and movement restrictions; b) steps towards Health Union; and c) the suspension of the fiscal rules and creation of the Next Generation EU and the Resilience and Recovery Fund. These raised major theoretical questions about legitimacy and the exercise of executive power during emergencies. This paper answers such questions by first considering democratic legitimacy in ordinary times in terms of the quality of governing activities related to output performance, input politics, and throughput procedures, as operationalized in terms of the ‘democratic audit.’ It next discusses the processes and problems of democratic legitimation in the EU with regard to leaders’ discourses of policy coordination and political communication. It then explores the complications for legitimacy and legitimation from emergency politics, and refines the democratic audit to apply to emergency politics. It follows by exploring how the exercise of executive power—coercive, institutional, and ideational/discursive—affects legitimacy and legitimation in emergency politics. Finally, the paper uses these theoretical criteria in a democratic audit of the empirical cases of bordering, health, and fiscal policy through process tracing and discourse analysis. It finds that governing authorities for the most part successfully discursively legitimated their actions on the grounds that positive output performance made up for reductions in political input and procedural throughput.
Referências para Poster Semana da Biologia UFSCar Sorocaba 2024
Creators: name: de Andrade Sebastião, Glaucia Isabel
name: Pita-Barbosa, Alice
name: Waldman, Walter
Publisher: name: Zenodo
Year: 2024

description: Referências utilizadas para poster da semana da biologia 2024 UFSCar Sorocaba
Review of the methods used for isolating pharmaceutical lead compounds from traditional medicinal plants
Creators: name: McRae, J.
name: Yang, Q.
name: Crawford, R.
name: Palombo, E.
Publisher: name: Swinburne
Year: 2024

description: The possibility of finding new medicines from natural sources is one of the most commonly cited reasons for preserving biodiversity. Further, the utilization of indigenous knowledge of medicinal plants increases the likelihood of discovering these hidden medicines. The main difficulty in using natural products as a source for pharmaceutical lead compounds lies in separating the plethora of compounds from the original extract. There is also a gamble with natural products in that the time and money invested in collecting the material and elucidating the active compounds may not yield any novel structures or compounds that can be used as pharmaceutical leads. While synthetic compounds have proven to be beneficial in the past, they are limited by structural simplicity and known modes of action. The production of novel medicines, particularly for cancer treatment and inhibition of antibiotic-resistant bacteria, now relies on the utilization of natural products. This paper provides a review of the current methods used in elucidating pharmaceutical lead compounds from natural sources, focusing on plant material in particular.
Most significant change
Creators: name: Wülser, Gabriela
Publisher: name: Zenodo
Year: 2020
Subjects: transdisciplinary research
knowledge co-production
Most significant change
method

description: This publication describes the most significant change technique and is part of a series of tools and methods compiled in the td-net toolbox for co-producing knowledge (www.transdisciplinarity.ch/toolbox).
 The most significant change technique is a story-based, qualitative method for uncovering most significant project impacts experienced by individuals.
description: Wülser G 2020. Most significant change technique. td-net toolbox profile (4). Swiss Academies of Arts and Sciences: td-net toolbox for co-producing knowledge. www.transdisciplinarity.ch/toolbox. doi.org/10.5281/zenodo.3717069
title: 03_0079
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Caregiving for Parkinson’s disease patients: an exploration of a stress-appraisal model for quality of life and burden
Creators: name: Goldsworthy, Belinda
Publisher: name: Swinburne
Year: 2024

description: Using an extension of Chappell and Reid’s (2002) stress-appraisal model, this study examined the relationships between a variety of caregiver stressors, appraisal, and protective factors associated with the burden and quality of life of Parkinson’s disease caregivers. A total of 136 Parkinson’s disease caregivers (39 males, 97 females; mean age= 64.59 years) participated in this study. Path analysis using Maximum Likelihood criterion, with Bollen-Stine bootstrap and standardised estimates was used to assess the model. Evaluation of the proposed model revealed that it was a good fit of the data. Supporting the hypotheses and Chappell and Reid’s (2002) model, were the findings that caree functional dependency and behavioural problems had an adverse impact on caregiver burden. In addition, caree functional dependency was found to be adversely related to caregiver quality of life. The results also found that frequency of breaks, perceived social support, and caregiver-caree relationship quality acted as protective factors of caregiver burden. Furthermore, the frequency of breaks acted as a protective factor of caregiver quality of life. This research provides an important contribution to a growing field of research applying theoretical models to investigate the stressors, appraisals, and protective factors that impact caregiver well-being.
Assessing the efficacy and standardization potential of five competing venture capital investment evaluation approaches
Creators: name: Mainprize, Brett
name: Hindle, Kevin
Publisher: name: Swinburne
Year: 2024

description: The research objective behind this article was to perform a critical evaluation and comparison of five representative business plan evaluation aids (BPEAs) to facilitate constructive discussion of the proposition that greater standardization of venture capital decision-making might be both desirable and possible. The five BPEAs were systematically compared using a structured, taxonomic process. The evidence of this investigation suggests a clear superiority of BPEAs that are based on the researched attributes of successful ventures and use actuarial modeling. Discussion centered on the importance of using BPEAs in a quest for greater consistency during venture capital investment decision-making.
Temporal trends in and relationships between screen time, physical activity, overweight and obesity
Creators: name: Duncan, Mitch J
name: Vandelanotte, Corneel
name: Caperchione, Cristina
name: Hanley, Christine
name: Mummery, W K
Publisher: name: BioMed Central
Year: 2016

description: Background: The aims of this study were to examine temporal trends in the prevalence of sufficient moderate-to-vigorous intensity physical activity (MVPA), high levels of screen time, combined measures of these behaviors and overweight or obesity in Australian adults during the period 2002–2008. Trends over this time period in overweight or obesity within each behavior group (sufficient/insufficient MVPA, high/low screen time and combined behaviors) were also examined. Methods: Data were collected via annually conducted cross-sectional computer-assisted-telephone-interviews (CATI) of adults (n=7908) living in Central Queensland, Australia (2002–2008). Self-reported MVPA, screen time (TV viewing and computer use), and BMI were used to create dichotomous classifications of physical activity (Sufficient MVPA (S-MVPA), Insufficient Physical Activity (I-MVPA)), screen time (High Screen Time (HST), Low Screen Time (LST)), combined behavior categories (S-MVPA/LST, I-MVPA/LST, S-MVPA/HST, I-MVPA/HST) and BMI (Overweight or Obese, Healthy Weight) respectively. Results: The prevalence of S-MVPA, HST, and overweight or obesity increased at approximately the same rate over the study period in the overall sample and females (p≤0.05). In the overall sample and in females, the prevalence of overweight and obesity increased over the study period in those individuals classified as I-MVPA/HST (p≤0.05). Conclusion: Results provide evidence that while the prevalence of S-MVPA appears to be modestly increasing, the proportion of the population engaging in HST and classified as overweight or obese are increasing at approximately the same rate. These observations highlight the need to increase levels of total physical activity (including light intensity physical activity) and decrease sedentary behavior including screen time.
Nomadic concepts
Creators: name: Rossini, Manuela
Publisher: name: Zenodo
Year: 2020
Subjects: transdisciplinary research
knowledge co-production
Nomadic concepts
Travelling concepts
method

description: This publication describes the nomadic concepts tool and is part of a series of tools and methods compiled in the td-net toolbox for co-producing knowledge (www.transdisciplinarity.ch/toolbox).
 Nomadic concepts is a heuristic tool for exchanging understandings of concepts across disciplinary, professional and cultural boundaries.
description: Rossini M 2020. Nomadic concepts. td-net toolbox profile (13). Swiss Academies of Arts and Sciences: td-net toolbox for co-producing knowledge. www.transdisciplinarity.ch/toolbox. doi.org/10.5281/zenodo.3717144
Acute care utilization due to hospitalizations for pediatric lower respiratory tract infections in British Columbia, Canada
Creators: name: Santibanez, Pablo
name: Gooch, Katherine
name: Vo, Pamela
name: Lorimer, Michelle
name: Sandino, Yurik
Publisher: name: BioMed Central
Year: 2016

description: Background: Pediatric LRTI hospitalizations are a significant burden on patients, families, and healthcare systems. This study determined the burden of pediatric LRTIs on hospital settings in British Columbia and the benefits of prevention strategies as they relate to healthcare resource demand. Methods: LRTI inpatient episodes for patients <19 years of age during 2008–2010 were extracted from the BC Discharge Abstract Database. The annual number of acute care beds required to treat pediatric LRTIs was estimated. Sub-analyses determined the burden due to infants <1 year of age and high-risk infants. Population projections were used to forecast LRTI hospitalizations and the effectiveness of public health initiatives to reduce the incidence of LRTIs to 2020 and 2030. Results: During 2008–2010, LRTI as the primary diagnosis accounted for 32.0 and 75.9% hospitalizations for diseases of the respiratory system in children <19 years of age and infants <1 year of age, respectively. Infants <1 year of age accounted for 47 and 77% hospitalizations due to pediatric LRTIs and pediatric LRTI hospitalizations specifically due to respiratory syncytial virus (RSV), respectively. The average length of stay was 3.1 days for otherwise healthy infants <1 year of age and 9.1 days for high-risk infants (P <0.0001). 73.1% pediatric LRTI hospitalizations occurred between November and April. Over the study timeframe, 19.6 acute care beds were required on average to care for pediatric LRTIs which increased to 64.0 beds at the peak of LRTI hospitalizations. Increases in LRTI bed-days of 5.5 and 16.2% among <19 year olds by 2020 and 2030, respectively, were predicted. Implementation of appropriate prevention strategies could cause 307 and 338 less LRTI hospitalizations in <19 year olds in 2020 and 2030, respectively. Conclusion: Pediatric LRTI hospitalizations require significant use of acute care infrastructure particularly between November and April. Population projections show the burden may increase in the next 20 years, but implementation of effective public health prevention strategies may contribute to reducing the acute care demand and to supporting efforts for overall pediatric healthcare sustainability.
Guardians of precision: advancing radiation protection, safety, and quality systems in nuclear medicine
Creators: name: Giammarile, F
name: Knoll, P
name: Kunikowska, J
name: Paez, D
name: Lobato, E Estrada
name: Mikhail-Lette, M
name: Wahl, R
name: Holmberg, O
name: Abdel-Wahab, M
name: Scott, Andrew
name: Bolton, RC Delgado
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences

description: Background: In the rapidly evolving field of nuclear medicine, the paramount importance of radiation protection, safety, and quality systems cannot be overstated. This document provides a comprehensive analysis of the intricate regulatory frameworks and guidelines, meticulously crafted and updated by national and international regulatory bodies to ensure the utmost safety and efficiency in the practice of nuclear medicine. Methods: We explore the dynamic nature of these regulations, emphasizing their adaptability in accommodating technological advancements and the integration of nuclear medicine with other medical and scientific disciplines. Results: Audits, both internal and external, are spotlighted for their pivotal role in assessing and ensuring compliance with established standards, promoting a culture of continuous improvement and excellence. We delve into the significant contributions of entities like the International Atomic Energy Agency (IAEA) and relevant professional societies in offering universally applicable guidelines that amalgamate the latest in scientific research, ethical considerations, and practical applicability. Conclusions: The document underscores the essence of international collaborations in pooling expertise, resources, and insights, fostering a global community of practice where knowledge and innovations are shared. Readers will gain an in-depth understanding of the practical applications, challenges, and opportunities presented by these regulatory frameworks and audit processes. The ultimate goal is to inspire and inform ongoing efforts to enhance safety, quality, and effectiveness in nuclear medicine globally.
Counterparty Credit Risk Framework
Creators: name: Xiao, Tim
Publisher: name: Zenodo
Year: 2022
Subjects: asset pricing; credit risk modeling; collateralization; comvariance; comrelation; correlation, CDS

description: This article presents a framework for capturing counterparty credit risk by accounting default correlation. We find that the CDS premium and the default correlations/comrelation have a negative relation. Intuitively, a protection seller who is positively correlated with the reference entity, i.e., a wrong way risk, should charge a lower premium for selling credit protection. Next, we also find that the impacts of the default correlations and comrelation are approximately linear. Finally, our study shows that the sensitivity slopes of the CDS premium to the default correlations and comrelation are negative. Slope measures the rate of change in the premium as a result of a change in the default dependence.
description: https://www.infona.pl/resource/bwmeta1.element.ID-74f411a6-60e2-4995-bc63-06d17c24ba27/tab/references
update on  https://doi.org/10.5281/zenodo.15334922
Creators: name: Hassanine, Sam
Publisher: name: Zenodo
Year: 2025
Subjects: space launch
electromagnetic rail
maglev propulsion
vertical acceleration
rocket fuel savings
space infrastructure
launch cost reduction
environmental impac
Tsiolkovsky equation
hybrid launch systems

description: update on  

https://doi.org/10.5281/zenodo.15334922
Older Persons’ Transitions in Care (OPTIC): a study protocol
Creators: name: Cummings, Greta G.
name: Reid, R. C.
name: Estabrooks, Carole A.
name: Norton, Peter G.
name: Cummings, Garnet E.
name: Rowe, Brian H.
name: Abel, Stephanie L.
name: Bissell, Laura
name: Bottorff, J. L. (Joan L.), 1950-
name: Robinson, Carole A.
name: Wagg, Adrian
name: Lee, Jacques S.
name: Lynch, Susan L.
name: Masaoud, Elmabrok
Publisher: name: BioMed Central
Year: 2016

description: Background: Changes in health status, triggered by events such as infections, falls, and geriatric syndromes, are common among nursing home (NH) residents and necessitate transitions between NHs and Emergency Departments (EDs). During transitions, residents frequently experience care that is delayed, unnecessary, not evidence-based, potentially unsafe, and fragmented. Furthermore, a high proportion of residents and their family caregivers report substantial unmet needs during transitions. This study is part of a program of research whose overall aim is to improve quality of care for frail older adults who reside in NHs. The purpose of this study is to identify successful transitions from multiple perspectives and to identify organizational and individual factors related to transition success, in order to inform improvements in care for frail elderly NH residents during transitions to and from acute care. Specific objectives are to: 1. define successful and unsuccessful elements of transitions from multiple perspectives; 2. develop and test a practical tool to assess transition success; 3. assess transition processes in a discrete set of transfers in two study sites over a one year period; 4. assess the influence of organizational factors in key practice locations, e.g., NHs, emergency medical services (EMS), and EDs, on transition success; and 5. identify opportunities for evidence-informed management and quality improvement decisions related to the management of NH – ED transitions. Methods/Design: This is a mixed-methods observational study incorporating an integrated knowledge translation (IKT) approach. It uses data from multiple levels (facility, care unit, individual) and sources (healthcare providers, residents, health records, and administrative databases). Discussion: Key to study success is operationalizing the IKT approach by using a partnership model in which the OPTIC governance structure provides for team decision-makers and researchers to participate equally in developing study goals, design, data collection, analysis and implications of findings. As preliminary and ongoing study findings are developed, their implications for practice and policy in study settings will be discussed by the research team and shared with study site administrators and staff. The study is designed to investigate the complexities of transitions and to enhance the potential for successful and sustained improvement of these transitions.
Autonomes Parken mit Parklückenerkennung
Creators: name: Bützer, Jannes
Publisher: name: Otto von Guericke University Library, Magdeburg, Germany
Year: 2020
Subjects: Lego

description: Anlässlich des Projektseminars Elektrotechnik/Informationstechnik an der Otto-von-Guericke-Universität Magdeburg sollte ein Roboter entwickelt werden, der die Funktionsweise eines Parkassistenten simuliert. In nachfolgender Arbeit wird veranschaulicht, wie sich dies mithilfe von Lego Mindstorms realisieren ließ. Dabei wird auch grafisch auf die Umsetzung des Roboters eingegangen. Neben Konstruktion und Programmierung erfolgt zudem eine Analyse der dabei aufgetretenen Schwierigkeiten und Probleme. Im Zuge des Projekts ist dabei ein Fahrzeug entstanden, das seine Parklücke selbstständig erkennt und sowohl ein- als auch ausparken kann. Hierbei wird zwischen Längs- und Querparken, sowie zwischen verschiedenen Größen der Parklücke differenziert.
description: LEGO-Praktikum, Bd. 3, ISSN 2629-6160
Linearization of ancestral multichromosomal genomes
Creators: name: Maňuch, Ján
name: Patterson, Murray
name: Wittler, Roland
name: Chauve, Cedric
name: Tannier, Eric
Publisher: name: BioMed Central
Year: 2016

description: Background: Recovering the structure of ancestral genomes can be formalized in terms of properties of binary matrices such as the Consecutive-Ones Property (C1P). The Linearization Problem asks to extract, from a given binary matrix, a maximum weight subset of rows that satisfies such a property. This problem is in general intractable, and in particular if the ancestral genome is expected to contain only linear chromosomes or a unique circular chromosome. In the present work, we consider a relaxation of this problem, which allows ancestral genomes that can contain several chromosomes, each either linear or circular. Result: We show that, when restricted to binary matrices of degree two, which correspond to adjacencies, the genomic characters used in most ancestral genome reconstruction methods, this relaxed version of the Linearization Problem is polynomially solvable using a reduction to a matching problem. This result holds in the more general case where columns have bounded multiplicity, which models possibly duplicated ancestral genes. We also prove that for matrices with rows of degrees 2 and 3, without multiplicity and without weights on the rows, the problem is NP-complete, thus tracing sharp tractability boundaries. Conclusion: As it happened for the breakpoint median problem, also used in ancestral genome reconstruction, relaxing the definition of a genome turns an intractable problem into a tractable one. The relaxation is adapted to some biological contexts, such as bacterial genomes with several replicons, possibly partially assembled. Algorithms can also be used as heuristics for hard variants. More generally, this work opens a way to better understand linearization results for ancestral genome structure inference.
Fostering indigenous entrepreneurship: a case study of the Membertou first nation, Nova Scotia, Canada
Creators: name: Kayseas, Robert
name: Hindle, Kevin
name: Anderson, Robert
Publisher: name: Swinburne
Year: 2024

description: What are the important factors that foster an environment for investment and entrepreneurship in Indigenous1 communities? Can these fostering factors, and those that hinder investment and entrepreneurship, be identified and generalized across communities and diverse cultures? If so, can the conditions that have been created within successful Canadian Indigenous communities, communities that foster the development and growth of entrepreneurial ventures, be recreated by other Indigenous nations? These questions form a small part of a research project being undertaken by the authors to explore Indigenous entrepreneurship in search of insight into the questions—what is Indigenous entrepreneurship, why do certain communities succeed at it, and what can be generalized from the success of certain successful Canadian Indigenous communities.
ENHANCING GLOBAL COMPETITIVENESS: A ROADMAP FOR MODERNIZING MANAGEMENT SYSTEMS IN UZBEK CORPORATIONS
Creators: name: Khodjaev, Javokhir
Publisher: name: Zenodo
Year: 2024

description: This article explores strategic measures for enhancing the management systems of Uzbek corporations to improve their global competitiveness. It delves into the integration of advanced technologies, strategic international alliances, and the development of a globally competent workforce. The paper highlights the importance of adhering to international standards and adopting sustainable practices to foster growth and resilience in the global marketplace.
Multispectral orthomosaic (J00009) - D6.3 Associated data (SOIL O-LIVE_HORIZON EUROPE ID 101091255)
Creators: name: Universidad de Jaén
Publisher: name: Zenodo
Year: 2025

description: Multispectral orthomosaic (J00009, Sabiote) - D6.3 Associated data (SOIL O-LIVE_HORIZON EUROPE ID 101091255)
Designation, diligence and drift: understanding laboratory expenditure increases in British Columbia, 1996/97 to 2005/06
Creators: name: Sivananthan, Saskia N.
name: Peterson, Sandra
name: Lavergne, Ruth
name: Barer, M. L.
name: McGrail, Kimberlyn M.
Publisher: name: BioMed Central
Year: 2015

description: Background: Laboratory testing is one of the fastest growing areas of health services spending in Canada. We examine the extent to which increases in laboratory expenditures might be explained by testing that is consistent with guidelines for the management of chronic conditions, by analyzing fee-for-service physician payment data in British Columbia from 1996/97 and 2005/06. Method We used direct standardization to quantify the effect on laboratory expenditures from changes in: fee levels; population growth; population aging; treatment prevalence; expenditure on recommended tests for those conditions; and expenditure on other tests. The chronic conditions selected were those with guidelines containing laboratory recommendations developed by the BC Guidelines and Protocol Advisory Committee: diabetes, hypertension, congestive heart failure, renal failure, liver disease, rheumatoid arthritis, osteoarthritis and dementia. Result Laboratory service expenditures increased by $98 million in 2005/06 compared to 1996/97, or 3.6% per year after controlling for population growth and aging. Testing consistent with guideline-recommended care for chronic conditions explained one-third (1.2% per year) of this growth. Changes in treatment prevalence were just as important, contributing 1.5% per year. Hypertension was the most common condition, but renal failure and dementia showed the largest changes in prevalence over time. Changes in other laboratory expenditure including for those without chronic conditions accounted for the remaining 0.9% growth per year. Conclusion Increases in treatment prevalence were the largest driver of laboratory cost increases between 1996/97 and 2005/06. There are several possible contributors to increasing treatment prevalence, all of which can be expected to continue to put pressure on health care expenditures.
ПРОБЛЕМА РАЗРАБОТКИ ТЕХНОГЕННЫХ ОБРАЗОВАНИЙ ОТРАБОТАННЫХ РОССЫПЕЙ ЗОЛОТА В ТУВЕ
Creators: name: ПРУДНИКОВ СЕРГЕЙ ГРИГОРЬЕВИЧ
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: ТЕХНОГЕННЫЕ ОТЛОЖЕНИЯ
ОТВАЛЫ
ТЕХНОГЕННЫЕ РОССЫПИ
РЕСУРСЫ ЗОЛОТА
РОССЫПИ
ТУВА
TECHNOGENIC DEPOSITS
DUMPS
TECHNOGENIC PLACERS
GOLD RESOURCES
PLACERS
TUVA

description: Рассмотрены три основных компонента проблемы разработки техногенных отложений, образованных в результате разработки россыпей золота Тувы: юридический, ресурсный, экологический. Техногенные отложения отработанных россыпей Тувы обладают достаточно высоким потенциалом для их повторной отработки. В изученных техногенных россыпях преобладает золото среднего класса, что гарантирует высокую извлекаемость при их отработке. Горно-геологические условия техногенных месторождений благоприятны для этого. Недопустимых экологических последствий повторное освоение месторождений не вызовет, учитывая малую глинистость песков и многолетний опыт эксплуатации предшественниками. В настоящее время основной преградой эксплуатации техногенных россыпей является отсутствие законодательной базы.
Mesoporous WCx Films with NiO‐Protected Surface: Highly Active Electrocatalysts for the Alkaline Oxygen Evolution Reaction
Creators: name: Frisch, Marvin
name: Ye, Meng‐Yang
name: Hamid Raza, Muhammad
name: Arinchtein, Aleks
name: Bernsmeier, Denis
name: Gomer, Anna
name: Bredow, Thomas
name: Pinna, Nicola
name: Kraehnert, Ralph
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: atomic layer deposition
subject: electrocatalysis
subject: metal carbides
subject: mesoporous materials
subject: nickel
subject: 540 Chemie und zugeordnete Wissenschaften

description: Metal carbides are promising materials for electrocatalytic reactions such as water electrolysis. However, for application in catalysis for the oxygen evolution reaction (OER), protection against oxidative corrosion, a high surface area with facile electrolyte access, and control over the exposed active surface sites are highly desirable. This study concerns a new method for the synthesis of porous tungsten carbide films with template-controlled porosity that are surface-modified with thin layers of nickel oxide (NiO) to obtain active and stable OER catalysts. The method relies on the synthesis of soft-templated mesoporous tungsten oxide (mp. WOx) films, a pseudomorphic transformation into mesoporous tungsten carbide (mp. WCx), and a subsequent shape-conformal deposition of finely dispersed NiO species by atomic layer deposition (ALD). As theoretically predicted by density functional theory (DFT) calculations, the highly conductive carbide support promotes the conversion of Ni2+ into Ni3+, leading to remarkably improved utilization of OER-active sites in alkaline medium. The obtained Ni mass-specific activity is about 280 times that of mesoporous NiOx (mp. NiOx) films. The NiO-coated WCx catalyst achieves an outstanding mass-specific activity of 1989 A gNi−1 in a rotating-disc electrode (RDE) setup at 25 °C using 0.1 m KOH as the electrolyte.
Dietary interventions for functional abdominal pain disorders in children: a systematic review and meta-analysis
Creators: name: de Bruijn, Clara MA
name: Rexwinkel, Robyn
name: Gordon, Morris
name: Sinopoulou, Vassiliki
name: Benninga, Marc A
name: Tabbers, Merit M
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Functional abdominal pain disorders (FAPDs) are common among children and are associated with decreased quality of life and school attendance. Several dietary interventions have been suggested to improve symptoms of FAPDs. This systematic review assessed the efficacy and safety of dietary interventions for pediatric FAPDs. Electronic databases were searched (inception–October 2021). Systematic reviews or RCTs were included if children (4–18 years) with FAPDs were treated with dietary interventions and compared to placebo, no diet or any other diet. Data extraction and assessment of quality of evidence based on GRADE system was independently performed by two review authors. Outcomes were treatment success, pain intensity and frequency, and withdrawal due to adverse events. Twelve articles were included, representing data of 819 pediatric FAPD patients. Trials investigating fibers, FODMAP diet, fructans, fructose-restricted diet, prebiotic (inulin), serum-derived bovine immunoglobulin, and vitamin D supplementation were included. We found very low-certainty evidence that the use of fibers leads to higher treatment success (NNT = 5). Based on current evidence, the use of fibers can be discussed in daily practice. High-quality intervention trials are highly needed to investigate if other dietary interventions are effective in the treatment of pediatric FAPD.
ВЗАИМООТНОШЕНИЯ ГАББРОИДОВ ЧАДАЛСКОГО И ЩЕЛОЧНЫХ ГРАНИТОИДОВ ШИВЕЙСКОГО МАССИВОВ (ВОСТОЧНАЯ ТУВА)
Creators: name: ХЕРТЕК АЙЛАН КЫМЗАЙ-ООЛОВНА
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: МЕХАНИЧЕСКОЕ ВЗАИМОДЕЙСТВИЕ
КОРОВЫЙ И МАНТИЙНЫЙ РАСПЛАВ
ШИВЕЙСКИЙ И ЧАДАЛСКИЙ МАССИВЫ
ВОСТОЧНАЯ ТУВА
MECHANICAL INTERACTION
CRUSTAL AND MANTLE MELTS
SHIVEY AND CHADAL MASSIVES
EASTERN TUVA

description: В настоящей работе представлены текстурно-структурные особенности щелочных гранитоидов Шивейского и габброидов Чадалского массивов и их взаимоотношения. Важной особенностью взаимоотношений обоих массивов является взаимное проникновение друг в друга с образованием крупных и мелких, брекчиеподобных и каплеобразных обособлений кварцевых сиенитов и гранитов в габброидах и наоборот. Подобные образования свидетельствуют о процессе механического взаимодействия базитового и корового расплавов в процессе их становления.
О ВОЗМОЖНОСТЯХ ПРИМЕНЕНИЯ МОДЕЛИ МЕЖОТРАСЛЕВОГО МОДЕЛИРОВАНИЯ ДЛЯ ПРОГНОЗА РАЗВИТИЯ РЕСПУБЛИКИ ТЫВА
Creators: name: ДАБИЕВ ДАВИД ФЕДОРОВИЧ
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: МЕЖОТРАСЛЕВОЙ БАЛАНС
ТЫВА
РЕГИОН
МОДЕЛЬ
СТРАТЕГИЯ
МУЛЬТИПЛИКАТИВНЫЙ ПРИРОСТ
ВРП
INTERDISCIPLINARY BALANCE
TUVA
REGION
MODEL
STRATEGY
MULTIPLICATIVE INCREMENT
GRP

description: Разработана предварительная модель межотраслевого баланса Республики Тыва для 15 видов экономической деятельности, который даёт возможность количественной оценки влияния факторов на величину и динамику валового регионального продукта. Показаны потенциальные возможности и преимущества использования модели межотраслевого баланса при разработке государственных стратегий развития промышленности и экономики Тувы.
ТУВИНСКО-МОНГОЛЬСКОЕ ПРИГРАНИЧЬЕ: ДИНАМИКА МЕЖЭТНИЧЕСКИХ СВЯЗЕЙ
Creators: name: ОЙДУП ТАНА МИХАЙЛОВНА
name: КЫЛГЫДАЙ АЙ-КЫС ЧАМДАЛОВНА
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: ПРИГРАНИЧЬЕ
ПРИГРАНИЧНЫЕ ТЕРРИТОРИИ
МЕЖЭТНИЧЕСКИЕ СВЯЗИ
ТУВА
МОНГОЛИЯ
BORDER-ZONE
BORDER TERRITORIES
INTERETHNIC RELATIONS
TUVA
MONGOLIA

description: В статье представлены результаты социологических опросов жителей приграничных районов Республики Тыва и аймаков Монголии по вопросам межэтнических связей. Опросы населения были проведены в 2010 и 2017 гг. по единой методике. В роли характеризующих признаков отношений были применены критерии: знание языка соседнего государства; признаки психоэмоциональных связей; отношение к обычаям и ценностям примыкающей нации, международным семьям; стремление эмигрировать на прилегающую территорию.
ГНЕЗДОВАНИЕ ОРЛАНА-БЕЛОХВОСТА (HALIAEETUS ALBICILLA L.) НА ОЗЕРЕ УБСУ-НУР (СЕВЕРО-ЗАПАДНАЯ МОНГОЛИЯ)
Creators: name: АРЧИМАЕВА ТАТЬЯНА ПЕТРОВНА
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: ОРЛАН-БЕЛОХВОСТ
HALIAEETUS ALBICILLA
УБСУ-НУР
СЕВЕРО-ЗАПАДНАЯ МОНГОЛИЯ
WHITE-TAILED EAGLE
UVS-NUUR
NORTH-WESTERN MONGOLIA

description: В последнее десятилетие на побережье оз. Убсу-Нура наблюдается увеличение численности редкого вида орлана-белохвоста ( Haliaeetus albicilla L.). По результатам обследования озера в 2014 г. число гнёзд возросло до трёх. Благополучию гнездовой группировки орлана-белохвоста на Убсу-Нуре способствует заповедный режим, установленный для большей части побережья озера, отсутствие беспокойства со стороны человека ввиду слабой заселённости прилегающих к озеру территорий и наличие богатой кормовой базы.
Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes
Creators: name: Schulte, Ina
name: Batty, Elizabeth M
name: Pole, Jessica C
name: Blood, Katherine A
name: Mo, Steven
name: Cooke, Susanna L
name: Ng, Charlotte
name: Howe, Kevin L
name: Chin, Suet-Feung
name: Brenton, James D
name: Caldas, Carlos
name: Howarth, Karen D
name: Edwards, Paul A
Publisher: name: BioMed Central
Year: 2016

description: Background: It has recently emerged that common epithelial cancers such as breast cancers have fusion genes like those in leukaemias. In a representative breast cancer cell line, ZR-75-30, we searched for fusion genes, by analysing genome rearrangements. Results: We first analysed rearrangements of the ZR-75-30 genome, to around 10kb resolution, by molecular cytogenetic approaches, combining array painting and array CGH. We then compared this map with genomic junctions determined by paired-end sequencing. Most of the breakpoints found by array painting and array CGH were identified in the paired end sequencing—55% of the unamplified breakpoints and 97% of the amplified breakpoints (as these are represented by more sequence reads). From this analysis we identified 9 expressed fusion genes: APPBP2-PHF20L1, BCAS3-HOXB9, COL14A1-SKAP1, TAOK1-PCGF2, TIAM1-NRIP1, TIMM23-ARHGAP32, TRPS1-LASP1, USP32-CCDC49 and ZMYM4-OPRD1. We also determined the genomic junctions of a further three expressed fusion genes that had been described by others, BCAS3-ERBB2, DDX5-DEPDC6/DEPTOR and PLEC1-ENPP2. Of this total of 12 expressed fusion genes, 9 were in the coamplification. Due to the sensitivity of the technologies used, we estimate these 12 fusion genes to be around two-thirds of the true total. Many of the fusions seem likely to be driver mutations. For example, PHF20L1, BCAS3, TAOK1, PCGF2, and TRPS1 are fused in other breast cancers. HOXB9 and PHF20L1 are members of gene families that are fused in other neoplasms. Several of the other genes are relevant to cancer—in addition to ERBB2, SKAP1 is an adaptor for Src, DEPTOR regulates the mTOR pathway and NRIP1 is an estrogen-receptor coregulator. Conclusions: This is the first structural analysis of a breast cancer genome that combines classical molecular cytogenetic approaches with sequencing. Paired-end sequencing was able to detect almost all breakpoints, where there was adequate read depth. It supports the view that gene breakage and gene fusion are important classes of mutation in breast cancer, with a typical breast cancer expressing many fusion genes.
НЕОБХОДИМОСТЬ ВНЕДРЕНИЯ ЭКОНОМИЧЕСКИ РАЦИОНАЛЬНЫХ МЕТОДОВ ЗАЩИТЫ РАСТЕНИЙ И МОНИТОРИНГ СЕЛЬСКОХОЗЯЙСТВЕННЫХ УГОДИЙ РЕСПУБЛИКИ ТЫВА
Creators: name: КУЖУГЕТ СВЕТЛАНА ВЛАДИМИРОВНА
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: ТЫВА
РАЦИОНАЛЬНЫЕ МЕТОДЫ
ЗАЩИТА РАСТЕНИЙ
АГРОЭКОСИСТЕМА
НАСЕКОМЫЕ
ВРЕДИТЕЛИ
TUVA
RATIONAL METHODS
PLANT PROTECTION
AGROECOSYSTEM
INSECTS
INVADERS

description: Приведено обоснование необходимости внедрения экономически рациональных методов защиты растений на различных агроэкосистемах Республики Тыва, осуществления регулярного мониторинга сельскохозяйственных угодий.
РЫБОПРОДУКТИВНОСТЬ ОЗЕРА ТОРЖ-ХОЛЬ ЗА СЧЁТ ИСПОЛЬЗОВАНИЯ ЕСТЕСТВЕННОЙ КОРМОВОЙ БАЗЫ
Creators: name: ХОВАЛЫГ ЧИНГИС АЙ-ХЕРЕЛОВИЧ
name: СУХИХ ЮРИЙ ЕВГЕНЬЕВИЧ
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: ОЗЕРО ТОРЖ-ХОЛЬ
ЗООПЛАНКТОН
ЗООБЕНТОС
РЫБОПРОДУКТИВНОСТЬ
LAKE TORZH-KHOL
ZOOPLANKTON
ZOOBENTOS
FISH CAPACITY

description: Получены сведения о рыбохозяйственном состоянии оз. Торж-Холь в Пий-Хемском районе Республики Тыва. Рассчитана естественная рыбопродуктивность для рыб-планктофагов (пелядь) до 343,6 кг / га, для рыб-бентофагов (сиг, карп) до 2,1 кг / га. Рассмотрены условия увеличения рыбопродуктивности озера за счёт мелиоративных работ.
Creating dynamic communities through new ventures: a city and regional study
Creators: name: Burnett, Hermina H. M.
name: Yamin, Shahid
Publisher: name: Swinburne
Year: 2024

description: This explorative study investigated the role and impact of entrepreneurial activity on economic growth through a comparison of two different business start-up initiatives. The first is the development of a business incubator in a city location in Australia and the second is the development of a technology park in regional Portugal. The study focused on how entrepreneurial teams can develop new ventures that facilitate business growth and how startup entrepreneurs can play a significant role in community motivation and the development of economic change in different regions of the world (Putnam, 1993). The study develops a conceptual framework to address the relationship between entrepreneurial activity and community development from a social capital perspective.
НЕЛИНЕЙНАЯ ЗАДАЧА ОПТИМИЗАЦИИ ПЛАНА ПРОИЗВОДСТВА
Creators: name: МОНГУШ БАЙЛАКМАА СЕРГЕЕВНА
Publisher: name: Природные ресурсы, среда и общество
Year: 2019
Subjects: МОДЕЛЬ ПЛАНИРОВАНИЯ ПРОИЗВОДСТВА
АССОРТИМЕНТ ТОВАРА
ПРИБЫЛЬ
НЕЛИНЕЙНОЕ ПРОГРАММИРОВАНИЕ
PRODUCTION PLANNING MODEL
PRODUCT MIX
PROFIT
NONLINEAR PROGRAMMING

description: В работе уточнено определение термина «ассортимент товара» и предложена математическая модель оптимизации плана производства предприятия, которая учитывает нелинейный характер зависимости цены товара от объёма производства. Проведена апробация на данных предприятия ООО «Кызылское учебно-производственное предприятие Всероссийского общества слепых» (ООО «Кызылское УПП ВОС»).