cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab
Creators: name: Niehr, Franziska
name: Weichert, Wilko
name: Stenzinger, Albrecht
name: Budach, Volker
name: Tinhofer, Ingeborg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: HNSCC
subject: mTOR
subject: EGFR
subject: Temsirolimus
subject: CCI-779
subject: Cetuximab
subject: Cisplatin
subject: Resistance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The mammalian target of rapamycin (mTOR) signaling pathway plays a pivotal role in numerous cellular processes involving growth, proliferation and survival. The purpose of this study was to investigate the anti-tumoral effect of the mTOR inhibitor (mTORi) CCI-779 in HNSCC cell lines and its potency in cisplatin- and cetuximab-resistant cells. Methods A panel of 10 HNSCC cell lines with differences in TP53 mutational status and basal cisplatin sensitivity and two isogenic models of acquired resistance to cisplatin and cetuximab, respectively were studied. Cell survival after treatment with CCI-779, cisplatin and cetuximab alone or in combination was determined by MTT assays. Potential predictive biomarkers for tumor cell sensitivity to CCI-779 were evaluated. Results We observed considerable heterogeneity in sensitivity of HNSCC cell lines to CCI-779 monotherapy. Sensitivity was observed in TP53 mutated as well as wild-type cell lines. Total and p-EGFR expression levels but not the basal activity of the mTOR and MAPK signaling pathways were correlated with sensitivity to CCI-779. Resistant cells with increased EGFR activation could be sensitized by the combination of CCI-779 with cetuximab. Interestingly, cell lines with acquired resistance to cisplatin displayed a higher sensitivity to CCI-779 whereas cetuximab- resistant cells were less sensitive to the drug, but could be sensitized to CCI-779 by EGFR blockade. Conclusions Activity of CCI-779 in HNSCC cells harboring TP53 mutations and displaying a phenotype of cisplatin resistance suggests its clinical potential even in patients with dismal outcome after current standard treatment. Cetuximab/mTORi combinations might be useful for treatment of tumors with high expression of EGFR/p-EGFR and/or acquired cetuximab resistance. This combinatorial treatment modality needs further evaluation in future translational and clinical studies.
Basiceros disciger
Creators: name: Arredondo, Brandon S.
name: Carreño-Guevara, Yennifer
name: Gutierrez-Villanueva, Yenifer
name: Duran-Bautista, Ervin Humprey
name: Gamboa-Tabares, Jean
name: Guerrero, Roberto J.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Basiceros
Basiceros disciger

description: Basiceros disciger (Mayr, 1887)
Materials
Type status: Other material. Occurrence: catalogNumber: LEUA- 00000066499; recordedBy: Brandon S. Arredondo; individualCount: 1; sex: female; occurrenceID: 19B846E0-CFAC-5490-B216-E3D819CC71FD; Taxon: scientificName: Basiceros disciger; kingdom: Animalia; phylum: Arthropoda; class: Insecta; order: Hymenoptera; family: Formicidae; genus: Basiceros; specificEpithet: disciger; scientificNameAuthorship: (Mayr, 1887); Location: continent: South America; country: Colombia; countryCode: CO; stateProvince: Caquetá; county: Florencia; locality: Vda. Sucre, Fca. Carlos Endo; verbatimElevation: 1018 m; locationRemarks: Collected in leaf Litter; verbatimCoordinates: 01°47'33.8"N 75°39'01.3"W; verbatimCoordinateSystem: WGS 84; Event: samplingProtocol: Winkler; eventDate: 2023-02-09; Record Level: language: es; collectionID: RNC: 270; institutionCode: Universidad de la Amazonia (UDLA); basisOfRecord: PreservedSpecimen
Diagnosis
This species is recognised within the genus Basiceros by the following characteristics: rounded occipital margin forming a continuous elevated crest, posterior crest of the vertex emarginate medially which meets the medial convexity of the vertex (Fig. 7).
Distribution
This species is rarely collected. In Colombia, it has been recorded in the Departments of Meta and Norte de Santander (Probst and Brandão 2022). It is reported here for the first time in the Department of Caquetá. In the Neotropical Region, the species has also been recorded in Argentina, Brazil, Ecuador, Paraguay, Peru and Venezuela (Probst and Brandão 2022).
Biology
B. disciger is a common species in leaf-litter samples and widely distributed. A distinctive characteristic of this species is it presence in both highly conserved and degraded areas, unlike other species of the genus (Probst and Brandão 2022).
description: Published as part of Arredondo, Brandon S., Carreño-Guevara, Yennifer, Gutierrez-Villanueva, Yenifer, Duran-Bautista, Ervin Humprey, Gamboa-Tabares, Jean & Guerrero, Roberto J., 2025, Soil and leaf litter ants from the Amazon Region offer new distribution records for Colombia, pp. e 142813 in Biodiversity Data Journal 13 on page e142813, DOI: 10.3897/BDJ.13.e142813
Compendium of Water Quality Regulatory Frameworks: Which Water for Which Use?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015

description: Water quality issues are complex and dynamic in nature and need urgent attention and action. Improving efficiency of water use requires regulatory frameworks that better reflect how different water uses require different water qualities, such as water from industrial processes being reused in agriculture.
Drafting regulatory instruments to better manage water qualities that are ´fit for purpose can benefit from the wide range of standards and guidelines currently available.
The Compendium contains a selection of recent water quality guidelines and standards for different uses. The immediate target group is public officials and regulators - decision makers at large.
Quelle: http://www.unwater.org
title: Hallazgos que nos pueden hacer sospechar hipertensión intracraneal benigna:revisión del seudotumor cerebral y nuestra experiencia.
Creators: name: Blanco Cabellos, Juan Antonio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cerebrospinal fluid
subject: Puncture
subject: Diagnostic procedure
subject: CT
subject: MR
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1-Hacer una revisión del tema incluyendoterminología,
epidemiología,
clínica y hallazgos en neuroimagen,
entre otros. 2-Mostrar los signos que pueden orientar al radiólogo sospechar un síndrome de hipertensión intracraneal benigna 3-Exponer...
Basic need satisfaction, emotional eating, and dietary restraint as risk factors for recurrent overeating in a community sample
Creators: name: Cleary, Jessica M.
name: Crafti, Naomi
Publisher: name: Swinburne
Year: 2024

description: This study examined potential risk factors of recurrent overeating by investigating relationships between basic need satisfaction, emotional eating, dietary restraint, body mass index and recurrent overeating. University students and women who accessed overeating related websites (N = 321) completed the Basic Need Satisfaction Inventory, the emotional and restraint subscales of the Dutch Eating Behaviour Questionnaire, the oversnacking and binging subscales of the Yale Eating Patterns Questionnaire; and provided demographic information. The study supported Modeling and Role-Modeling theory, as basic need satisfaction negatively correlated with emotional eating, and self-esteem and self-actualisation significantly predicted emotional eating. Analysis of an adaptation of the cognitive-behavioural model of bulimia nervosa showed that emotional eating mediated the relationship between both self-esteem and self-actualisation and recurrent overeating, and interestingly, dietary restraint was not related to other variables. It was concluded that intervention for binge eating should reflect the importance of psychological triggers rather than only behavioural cues.
title: El linfoma primario del SNC: Presentaciones poco habituales en RM
Creators: name: Arevalo Perez, Julio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Explorar las multiples presentaciones de linfoma primario con casos procedentes del Memorial Sloan-Kettering Cancer Center de Nueva York. Demostrar la utilidad de tecnicas avanzadas de RM para mejorar el...
Supplementary document for Helicity-dependent Receiver-Transmitter metasurfaces for full-space wavefront manipulation - 4790708.pdf
Creators: name: Hou, Haisheng
name: Wang, Guang-Ming
name: Li, Haipeng
name: Guo, Wenlong
name: Cai, Tong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Documen
title: Signos en radiología convencional de tórax: cómo afrontarlos en la actualidad.
Creators: name: Goiburu Gonzalez, Laura
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Conventional radiography
subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar una revisión gráfica de los signos clásicos en la radiología de tórax dado que es una de las primeras exploraciones radiológicas y la más solicitada por cualquier médicoconstituyendo aúnun desafío para todo...
A review of econometric approaches for estimating input allocation in agriculture: a focus on strengths and weaknesses
Creators: name: Mamiharimalala, S. N.
Publisher: name: Unknown
Year: 2025
Subjects: subject: Agribusiness
subject: Agricultural Finance
subject: Research and Development/Tech Change/Emerging Technologies
subject: Research Research Methods/Statistical Methods
subject: cost/input allocation
subject: classical regression
subject: random parameter models
subject: Bayesian
subject: entropy approach
subject: machine learning

description: Understanding input allocation—the process of distributing aggregated inputs across production activities (Britz, 2004)—plays a central role in agricultural economics. However, it remains a challenge, particularly in multi-output systems where firm-level input data is often aggregated. Traditional survey-based approaches are costly and often impractical, highlighting the need for more effective methods. In this context, this paper reviews four main econometric approaches to input allocation: classical regression models, random parameter methods, entropy-based techniques, and Bayesian estimation. Each method is assessed in terms of its theoretical foundations, strengths, and limitations. Particular focus is given to two recent methodologies—SAEM-based random parameter modeling and Highest Posterior Density estimation—which address key issues of econometric techniques of input allocation. By comparing these approaches, this study provides practical guidelines to help users choose the most suitable method based on relevance, simplicity, and computational strength. Finally, potential extensions, including the integration of machine learning techniques into cost allocation models, are discussed for future research purposes.
title: Espectro de anormalidades en el desarrollo del VIII par craneal (estatoacústico)
Creators: name: Martínez Barbero, José Pablo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Dysplasias
subject: Congenital
subject: Computer Applications-3D
subject: CT-High Resolution
subject: MR
subject: Ear / Nose / Throat
subject: Neuroradiology peripheral nerve
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Objetivo docente - Conocer las principales causas de hipoacusia de causa congénita - Recordar los hallazgos más frecuentes en las anomalías del desarrollo del VII par - Mostrar las técnicas y protocolos de imagen más apropiados para su...
Additional file 1 of IARS2 mutations lead to Leigh syndrome with a combined oxidative phosphorylation deficiency
Creators: name: Dong, Qiyu
name: Yin, Xiaojie
name: Fan, Shuanglong
name: Zhong, Sheng
name: Yang, Wenxin
name: Chen, Keer
name: Wang, Qian
name: Ma, Xue
name: Mahlatsi, Refiloe Laurentinah
name: Yang, Yanling
name: Lyu, Jianxin
name: Fang, Hezhi
name: Wang, Ya
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Diabetes care in pediatric refugees from Africa or Middle East – experiences from Germany and Austria based on real-world data from the DPV registry
Creators: name: Prinz, Nicole
name: Konrad, Katja
name: Brack, Christoph
name: Hahn, Eva
name: Herbst, Antje
name: Icks, Andrea
name: Grulich-Henn, Jürgen
name: Jorch, Norbert
name: Kastendieck, Christian
name: Mönkemöller, Kirsten
name: Razum, Oliver
name: Steigleder-Schweiger, Claudia
name: Witsch, Michael
name: Holl, Reinhard
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: diabetes care
subject: diabetes registry
subject: DDC 610 / Medicine & health
subject: Diabetes mellitus, Type 1
subject: Africa
subject: Middle East
subject: Refugees
subject: Diabetes mellitus Typ 1
subject: Naher Osten
subject: Flüchtling

description: Objective: With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe current experience with pediatric refugees in Germany and Austria. Design and Methods: 43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were studied, and divided by refugee status into patients born in Middle East (n=365) or Africa (n=175) and native patients (child and parents born in Germany/Austria; G/A: n=42,597). Groups were compared using multivariable regression adjusted for age, sex and diabetes duration (SAS 9.4). In refugees the first year after arrival was studied, and for native children the most recent year of care. Results: After adjustment, HbA1c was highest in refugees (ME vs. AFR vs. G/A: 72.3±1.0 vs. 75.0±1.4 vs. 66.0±0.1 mmol/mol, each p<0.001) and microalbuminuria (9.9 vs 13.6 vs. 6.5%, each p<0.05) was more prevalent. African children experienced severe hypoglycemia (17.8±4.3 vs. 25.4±8.7 vs. 11.5±0.3 per 100 patient years) significantly more often, whereas hypoglycemia with coma (5.1±1.1 vs. 4.1±1.6 vs. 2.6±0.1 per 100 patient years) and retinopathy (2.1 vs. n/a vs. 0.2%) were significantly more common in children from Middle East compared to natives. Insulin pumps were used in a markedly larger proportion of native patients (7.4 vs. 13.2 vs. 43.0%, each p<0.001). Conclusions: A relevant number of pediatric refugees with type 1 diabetes are treated in German/Austrian diabetes clinics. Refugee children, parents and caregivers are faced with several problems in diabetes therapy and outcome that should be addressed more intensively by pediatric diabetes teams.
Social capital, health and electronic community in public high-rise estates: an Australian case-study
Creators: name: Hopkins, Liza
Publisher: name: Swinburne
Year: 2024

description: The four years from 2001 to 2005 saw the roll out of an innovative social enterprise on one of Melbourne’s high rise public housing estates, Atherton Gardens. It provided residents with access to personal computers, computer training, an intranet, internet and email, as well as establishing a training room, open access computer lab, repairs workshop and a help desk service for computer users. This paper reports on a three year research project which was undertaken to assess the impact of this initiative and to analyse its effects, not only on residents’ access to and use of new forms of information and communication technologies, but also the less tangible effects of an electronic network on health, social capital and community well-being.
title: COLECISTOSTOMÍA PERCUTÁNEA:experiencia en un hospital comarcal.
Creators: name: Pastor Juan, María Rosario
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Interventional non-vascular
subject: CT
subject: Catheters
subject: Instrumentation
subject: Technical aspects
subject: Pathology
subject: Acute
subject: Inflammation

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1.- Proponer la colecistostomía percutánea como tratamiento de colecistitis aguda en pacientes con alto riesgo quirúrgico como paso previo a realización de colecistectomía programada. 2.- Repasar los principales factores de riesgo recogidos en...
Supplementary document for Helicity-dependent Receiver-Transmitter metasurfaces for full-space wavefront manipulation - 4790708.pdf
Creators: name: Hou, Haisheng
name: Wang, Guang-Ming
name: Li, Haipeng
name: Guo, Wenlong
name: Cai, Tong
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental Documen
Kempfidris inusualis
Creators: name: Arredondo, Brandon S.
name: Carreño-Guevara, Yennifer
name: Gutierrez-Villanueva, Yenifer
name: Duran-Bautista, Ervin Humprey
name: Gamboa-Tabares, Jean
name: Guerrero, Roberto J.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Kempfidris
Kempfidris inusualis

description: Kempfidris inusualis (Fernández, 2007)
Materials
Type status: Other material. Occurrence: catalogNumber: LEUA- 00000066487; recordedBy: Luz Albenis Villaquiran; individualCount: 1; sex: female; occurrenceID: BB3475BB-75C4-5FB1-8CC0-7F54063948B8; Taxon: scientificName: Kempfidris inusualis; kingdom: Animalia; phylum: Arthropoda; class: Insecta; order: Hymenoptera; family: Formicidae; genus: Kempfidris; specificEpithet: inusualis; scientificNameAuthorship: (Fernández, 2007); Location: continent: South America; country: Colombia; countryCode: CO; stateProvince: Caquetá; county: Florencia; locality: Vda. La Viciosa, CIMAZ Macagual; verbatimElevation: 320 m; locationRemarks: Collected in leaf Litter; verbatimCoordinates: 01°29'46"N 75°39'19"W; verbatimCoordinateSystem: WGS 84; Event: samplingProtocol: Monolite / TSBF; eventDate: 2023-09-12; Record Level: language: es; collectionID: RNC: 270; institutionCode: Universidad de la Amazonia (UDLA); basisOfRecord: PreservedSpecimen
Diagnosis
The genus and species can be distinguished from any other Myrmicine ant by a posteromedian portion of abdominal tergum VI and anteromedian portion of abdominal tergum VII with several minute, cylindrical micro-pegs, each bearing a hair on apex (Fig. 9) (Fernández et al. 2014).
Distribution
Kempfidris inusualis is a Neotropical species restricted to the Amazon rainforest. In Colombia, it is only known from the Department of Amazonas (Castro et al. 2018). It is reported here for the first time in the Department of Caquetá. In the Neotropical Region, the species has also been recorded in Ecuador, Peru, Brazil and Venezuela (Fernández et al. 2014, Camacho and Feitosa 2016).
Biology
This species was collected in the leaf litter in secondary forest near a fallen log in an Andean-Amazonian transition zone in the foothills of Amazonia.
Notes
Fernández (2007) mentions that the morphological variability of the species is low, finding a variation in colouration, with more than one difference in the dorsal face of the propodeum and in the propodeal ridges, attributing this variation to the geographical distribution of the species.
description: Published as part of Arredondo, Brandon S., Carreño-Guevara, Yennifer, Gutierrez-Villanueva, Yenifer, Duran-Bautista, Ervin Humprey, Gamboa-Tabares, Jean & Guerrero, Roberto J., 2025, Soil and leaf litter ants from the Amazon Region offer new distribution records for Colombia, pp. e 142813 in Biodiversity Data Journal 13 on page e142813, DOI: 10.3897/BDJ.13.e142813
The neuroleptic malignant syndrome—a systematic case series analysis focusing on therapy regimes and outcome
Creators: name: Kuhlwilm, Lilli
name: Schönfeldt-Lecuona, Carlos
name: Gahr, Maximilian
name: Connemann, Bernhard J.
name: Keller, Ferdinand
name: Sartorius, Alexander
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: DDC 610 / Medicine & health
subject: Antipsychotics
subject: Neuroleptic malignant syndrome; Therapy
subject: Antipsychotic agents
subject: Malignes neuroleptisches Syndrom
subject: Neuroleptikum

description: Introduction Neuroleptic malignant syndrome (NMS) is a rare, potentially life‐threatening antipsychotic‐associated disorder that requires an efficient and timely therapy. The aim of the study was to compare the effectiveness of different NMS therapies and to analyze its outcome depending on NMS severity. Method Systematic search for NMS cases in biomedical databases. The focus of the analysis was on therapy with dantrolene, bromocriptine, and electroconvulsive therapy (ECT) when each was compared with symptomatic therapy. Primary outcomes were the survival rate and the duration of treatment. Result 405 case reports were included. Overall, no statistically significant differences regarding mortality rate or duration of treatment were found between dantrolene, bromocriptine, or ECT compared to supportive care. A subgroup analysis regarding NMS severity showed that the mortality under specific NMS pharmacotherapy (dantrolene, bromocriptine) and under ECT was significantly lower than under purely symptomatic therapy in severe NMS (P = 0.018). The difference was not significant in mild and moderate cases. Discussion An overall superiority of the specific NMS therapy (dantrolene, bromocriptine, and ECT) was not found in this study. When regarding severity classification, specific therapies were superior but only in severe cases, and ECT showed the lowest mortality rate. In previous case series, an effect on survival or the duration of the disease could only be observed in part for specific therapies, but the evidence available is inconsistent. The results of this study support our hypothesis that NMS treatment with dantrolene, bromocriptine, and ECT is advantageous over purely symptomatic therapy in severe NMS cases.
title: La Aventura de Leer
Creators: name: Saralegui Prieto, Ibone
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Diagnostic procedure
subject: Education
subject: Technical aspects
subject: MR-Functional imaging
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisión del estado del arte de las teorías desarrolladas para explicar el complejo proceso de leer y describir las áreas cerebrales específicas involucradas en este proceso mediante Resonancia Magnética Funcional (fMRI) en base a nuestra...
Supplementary document for High accuracy cross-sectional shape analysis by coherent soft X-ray diffraction - 4790761.pdf
Creators: name: Hoshino, Tetsuya
name: Shiono, Masahiko
name: Banerjee, Saswatee
name: Aoki, Sadao
name: Sakurai, Kenji
name: Itoh, Masahide
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplements 1, 2 and 3
Providing media control to SIP-based IVR applications: The IVRObject approach
Creators: name: Simoes, Renato
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Computer Science.

description: A popular application that runs on a Voice-over-IP network is the Interactive Voice Response (IVR), which provides a way for interacting with an end user's phone via a telephony interface by presenting a set of audible menu options, and collecting the user's Dual Tone Multi-Frequency responses as the user presses the telephone numeric keypad, and recording the user's voice. This thesis takes a closer look into IVR systems on an IP-based network, specifically in networks that support the Session Initiation Protocol (SIP) for controlling the telephony signalling, and more specifically on IVR systems that have their SIP signalling controlled by a SIP Application Server (SIPAS) implementing the SipServlet 1.0 or 1.1 specifications and where a SIP-based Media Server is used to stream IVR media to the end-user. We describe existing ways for supporting an IVR development in a SIP network, and then we propose an alternative way of accomplishing the same task: the IVRObject. With the help of prototypes, the IVRObject is compared with the existing state of the art against three criteria: (a) how easy it is to develop, (b) how portable the development solution is, (c) and how scalable the solution is in order to sustain a high call volume. As a conclusion, it will be highlighted that the IVRObject provides an easy mechanism for development of IVR-based applications running on a SIPAS, that it is portable to different media server vendors, and that it supports a test strategy that can be leveraged to improve software development quality and faster development. This makes the IVRObject a good alternative especially for enterprise-based IVR applications where scalability is less of an issue than in carrier-space applications.
Older adults’ experiences of a physical activity and sedentary behaviour intervention: a nested qualitative study in the SITLESS multi-country randomised clinical trial
Creators: name: Blackburn, Nicole
name: Skjodt, Mathias
name: Tully, Mark
name: Mc Mullan, Ilona
name: Giné-Garriga, Maria
name: Caserotti, Paolo
name: Blancafort, Sergi
name: Santiago, Marta
name: Rodriguez-Garrido, Sara
name: Weinmayr, Gudrun
name: John-Köhler, Ulrike
name: Wirth, Katharina
name: Jerez-Roig, Javier
name: Dallmeier, Dhayana
name: Wilson, Jason
name: Deidda, Manuela
name: McIntosh, Emma
name: Coll-Planas, Laura
name: On Behalf Of The SITLESS Group,
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: exercise referral schemes
subject: qualitative study
subject: behaviour change
subject: physical activity
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Exercise
subject: Qualitative Research
subject: Sedentary Behavior
subject: Aging
subject: Altern

description: Background: The SITLESS programme comprises exercise referral schemes and self-management strategies and has been evaluated in a trial in Denmark, Spain, Germany and Northern Ireland. The aim of this qualitative study was to understand the implementation and contextual aspects of the intervention in relation to the mechanisms of impact and to explore the perceived effects. Methods: Qualitative methodologies were nested in the SITLESS trial including 71 individual interviews and 12 focus groups targeting intervention and control group participants from postintervention to 18-month follow-up in all intervention sites based on a semi-structured topic guide. Results: Overarching themes were identified under the framework categories of context, implementation, mechanisms of impact and perceived effects. The findings highlight the perceived barriers and facilitators to older adults’ engagement in exercise referral schemes. Social interaction and enjoyment through the group-based programmes are key components to promote adherence and encourage the maintenance of targeted behaviours through peer support and connectedness. Exit strategies and signposting to relevant classes and facilities enabled the maintenance of positive lifestyle behaviours. Conclusions: When designing and implementing interventions, key components enhancing social interaction, enjoyment and continuity should be in place in order to successfully promote sustained behaviour change.
Entry-to-Practice PharmD Program : Interprofessional Education -- Master Plan
Creators: name: Min, Jason
name: Leung, Larry
Publisher: name: The University of British Columbia
Year: 2019

description: Interprofessional Education (IPE) at the Faculty of Pharmaceutical Sciences is under the portfolio of the Office of Experiential Education. Our vision for IPE is to become a global leader in a competency-based program in pharmacy that is integrated and collaborative, to support students in becoming effective interprofessional collaborators in patient care. IPE occurs when students, healthcare workers, or health professionals from two or more disciplines work collaboratively to “learn about, from and with each other to enable effective collaboration and improve health outcomes” World Health Organization, 2010.
Genomic characterization of cyclostome Dlx gene family members: Insight into the evolution of the chordate genome and body plan from the organizational and transcriptional regulatory properties of Dlx genes in the petromyzontiformes (lamprey) and the hyperotreti (Hagfish)
Creators: name: Martin, Kyle J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Genetics.
subject: Biology, Evolution and Development.

description: Gnathostome novelties include jaws, paired appendages, and true teeth. Dlx genes encode transcription factors indispensable for embryonic development of these novelties. Gnathostomes possess at least 6 Dlx genes organized in 3 bi-gene clusters, a physical arrangement which is proposed to affect their expression though shared enhancer elements. I studied the Dlx genes of Cyclostomes, the evolutionary sister group of Gnathostomes. I identified 4 novel members of the Dlx gene family in hagfish (Eptatretus stoutii), and confirmed the presence of 6 Dlx genes in lamprey ( Petromyzon marinus). I found that Cyclostomes have only 1 gene cluster and several orphan genes. This lack of conserved arrangement is coincident with an absence of conserved Dlx enhancers. Irregardless, some regulatory conservation is still apparent as lamprey non-coding DNA is able to drive dlx specific expression patterns of reporter genes in zebrafish. Therefore Cyclostome and Gnathostome Dlx are both organized and regulated differently. The causes and consequences of these changes in Chordate evolution are discussed.
Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling
Creators: name: Remm, Friederike
name: Kränkel, Nicolle
name: Lener, Daniela
name: Drucker, Daniel J.
name: Sopper, Sieghart
name: Brenner, Christoph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Sitagliptin
subject: antidiabetic drugs
subject: regeneration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Introduction. DPP4 inhibitors (gliptins) are commonly used antidiabetic drugs for the treatment of type 2 diabetes. Gliptins also act in a glucose- independent manner and show vasoregenerative effects. We have shown that gliptins can remarkably accelerate vascular healing after vascular injury. However, the underlying mechanisms remain unclear. Here, we examined potential signaling pathways linking gliptins to enhanced endothelial regeneration. Methods and Results. We used wild-type and GLP1 receptor knockout (Glp1r−/−) mice to investigate the underlying mechanisms of gliptin-induced reendothelialization. The prototype DPP4 inhibitor sitagliptin accelerated endothelial healing in both animal models. Improved endothelial growth was associated with gliptin-mediated progenitor cell recruitment into the diseased vascular wall via the SDF1-CXCR4 axis independent of GLP1R-dependent signaling pathways. Furthermore, SDF1 showed direct proproliferative effects on endothelial cells. Excessive neointimal formation was not observed in gliptin- or placebo-treated Glp1r−/− mice. Conclusion. We identified the SDF1-CXCR4 axis as a crucial signaling pathway for endothelial regeneration after acute vascular injury. Furthermore, SDF1 can directly increase endothelial cell proliferation. Gliptin-mediated potentiation of endothelial regeneration was preserved in Glp1r−/− animals. Thus, gliptin-mediated endothelial regeneration proceeds through SDF-1/CXCR4 in a GLP1R-independent manner after acute vascular injury.
Gravitational stability of circumnuclear disks in elliptical galaxies
Creators: name: Kawata, Daisuke
name: Cen, Renyue
name: Ho, Luis C.
Publisher: name: Swinburne
Year: 2024

description: A significant fraction of nearby elliptical galaxies are known to have high-density gas disks in their circumnuclear (CN) region (0.1 to a few kpc). Yet ellipticals, especially luminous ones, show little sign of recent star formation. To investigate the possible cause of the dearth of star formation in these systems, we study the gravitational stability of CN gas disks embedded within the gravitational potentials of both the stellar bulge component and the central massive black hole (BH) in elliptical galaxies. We find that CN disks in higher mass galaxies are generally more stable than those in lower mass galaxies, because higher mass galaxies tend to have more massive BHs and more centrally concentrated stellar density profiles. We also consider the case in which the central stellar density profile has a core, which is often observed for ellipticals whose total stellar mass is higher than about 1011 . Such a cored stellar density profile leads to more unstable CN disks than the power-law stellar density profile characteristic of less massive galaxies. However, the more massive BHs in high-mass galaxies act to stabilize the CN disk. Our results demonstrate that the gravitational potentials of both the central BH and the stellar component should be taken into account when studying the properties of CN disks, as their stability is sensitive to both the BH mass and the stellar density profile. Our results could explain the observed trend that less luminous elliptical galaxies have a greater tendency to exhibit ongoing star formation than giant ellipticals.
Supplementary document for High accuracy cross-sectional shape analysis by coherent soft X-ray diffraction - 4790761.pdf
Creators: name: Hoshino, Tetsuya
name: Shiono, Masahiko
name: Banerjee, Saswatee
name: Aoki, Sadao
name: Sakurai, Kenji
name: Itoh, Masahide
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Classical and Physical Optics

description: Supplements 1, 2 and 3
Gemcitabine as adjuvant chemotherapy in patients with high-risk early breast cancer—results from the randomized phase III SUCCESS-A trial
Creators: name: De Gregorio, Amelie
name: Häberle, Lothar
name: Fasching, Peter Andreas
name: Müller, Volkmar
name: Schrader, Iris
name: Lorenz, Ralf
name: Forstbauer, Helmut
name: Friedl, Thomas W. P.
name: Bauer, Emanuel
name: De Gregorio, Nikolaus
name: Deniz, Miriam
name: Fink, Visnja
name: Bekes, Inga
name: Andergassen, Ulrich
name: Schneeweiss, Andreas
name: Tesch, Hans
name: Mahner, Sven
name: Brucker, Sara
name: Blohmer, Jens-Uwe
name: Fehm, Tanja
name: Heinrich, Georg
name: Lato, Krisztian
name: Beckmann, Matthias Wilhelm
name: Rack, Brigitte K.
name: Janni, Wolfgang
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Early breast cancer
subject: Gemcitabine
subject: Chemotherapy
subject: DDC 610 / Medicine & health
subject: Breast neoplasms; Drug therapy
subject: Brustkrebs
subject: Chemotherapie

description: Background When chemotherapy is indicated in patients with early breast cancer, regimens that contain anthracyclines and taxanes are established standard treatments. Gemcitabine has shown promising effects on the response and prognosis in patients with metastatic breast cancer. The SUCCESS-A trial (NCT02181101) examined the addition of gemcitabine to a standard chemotherapy regimen in high-risk early breast cancer patients. Methods A total of 3754 patients with at least one of the following characteristics were randomly assigned to one of the two treatment arms: nodal positivity, tumor grade 3, age ≤ 35 years, tumor larger than 2 cm, or negative hormone receptor status. The treatment arms received either three cycles of 5-fluorouracil, epirubicin, and cyclophosphamide, followed by three cycles of docetaxel (FEC → Doc); or three cycles of FEC followed by three cycles of docetaxel and gemcitabine (FEC → Doc/Gem). The primary study aim was disease-free survival (DFS), and the main secondary objectives were overall survival (OS) and safety. Results No differences were observed in the 5-year DFS or OS between FEC → Doc and FEC → Doc/Gem. The hazard ratio was 0.93 (95% CI, 0.78 to 1.12; P = 0.47) for DFS and 0.94 (95% CI, 0.74 to 1.19; P = 0.60) for OS. For patients treated with FEC → Doc and FEC → Doc/Gem, the 5-year probabilities of DFS were 86.6% and 87.2%, and the 5-year probabilities of OS were 92.8% and 92.5%, respectively. Conclusion Adding gemcitabine to a standard chemotherapy does not improve the outcomes in patients with high-risk early breast cancer and should therefore not be included in the adjuvant treatment setting.
Assessment of spatial variability of precipitation in Krishna River Basin using a metric based on apportionment entropy
Creators: name: Kumar, Salvadi Chetan
name: N, Siva Sai Syam
name: Rathinasamy, Maheswaran
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: A new standardized metric, the standardized spatial variability index (SSVI), was developed using apportionment entropy. The proposed SSVI was used to study the spatial variability of precipitation extremes and volumes in the Krishna River basin (KRB), India, using gridded data from 1901 to 2020. The analysis was performed at three spatial and two temporal scales. Results show that the proposed SSVI can better capture spatial variability than traditional methods. KRB experienced a significant spatial variability in precipitation volume and extremes. More importantly, there is a concentration of extreme precipitation events in the western part compared to the eastern part. The variability of extreme events showed a significant correlation with the mean elevation of the catchments. Trend analysis reveals significant increasing trends observed in SSVI of extreme precipitation events in the northwestern KRB over the study period, indicating that extreme precipitation events have been evenly spread across the catchment in recent decades.
Evidence that the Human Auditory System Learns Rules Without Conscious Awareness
Creators: name: Sculthorpe, Lauren Deano
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Psychology, Psychobiology.
subject: Psychology, Cognitive.

description: The focused sense of self that is central to our experience of consciousness could not exist without human brain's ability to process large amounts of information outside of conscious awareness. The Mismatch Negativity (MMN) is thought to index one such pre-conscious mechanism, a complex novelty detector that compares incoming sounds to rules that it has extracted from the recent acoustic past. Processes that do not require conscious awareness are considered to be "automatic". The automaticity of the MMN, however, has predominantly been studied using very simple stimuli. The present dissertation studied the issue of automaticity using a two-tone alternating pattern (e.g., ABABABAB...) as the "standard" stimuli. MMN-eliciting deviants were rule-violating tone repetitions (e.g., ABABAA&barbelow;AB...). Three studies took complementary approaches to the problem of automaticity. Study 1 tested the automaticity of the detection of rule violations by varying the presumed attentional demands of a visual task, while the auditory pattern was ignored. The MMN was unaffected by visual task difficulty, but it may be impossible for awake, alert subjects to ever fully ignore incoming sounds. Study 2, therefore, studied the MMN during natural sleep, the period of time when the observer is least conscious of the external environment. An MMN was elicited in both the waking state and REM sleep. Interpreted in isolation, these studies might be taken as evidence that the MMN is strongly automatic. Some attention effects, however, have been reported. One proposed mechanism for these attention effects is that attention increases the strength of the memory for the frequently-presented, standard stimuli. Study 3 examined whether the MMN varies with the strength of the memory for the standard by manipulating the number of memory-reinforcing repetitions of the standard that occurred between successive deviants. The results of Study 3 suggest that the amplitude of the MMN is unrelated to the strength of the memory for the standard. Altogether, the results of these studies suggest that even complex, rule-based MMN elicitation is an automatic process, and that studies demonstrating evidence to the contrary should be examined for the influence of other confounding factors.
Supplementary document for Single wavelength measurements of absorption coefficients based on iso-pathlength point - 4790886.pdf
Creators: name: Feder, Idit
name: Duadi, Hamootal
name: Fixler, Dror
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplementary materials for the DPF shortening in case of absorption
Supplementary document for Single wavelength measurements of absorption coefficients based on iso-pathlength point - 4790886.pdf
Creators: name: Feder, Idit
name: Duadi, Hamootal
name: Fixler, Dror
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: supplementary materials for the DPF shortening in case of absorption
Lenomyrmex inusitatus
Creators: name: Arredondo, Brandon S.
name: Carreño-Guevara, Yennifer
name: Gutierrez-Villanueva, Yenifer
name: Duran-Bautista, Ervin Humprey
name: Gamboa-Tabares, Jean
name: Guerrero, Roberto J.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Lenomyrmex
Lenomyrmex inusitatus

description: Lenomyrmex inusitatus (Fernández, 2001)
Materials
Type status: Other material. Occurrence: catalogNumber: LEUA- 00000066496; recordedBy: Yenifer Gutierrez; individualCount: 1; sex: female; occurrenceID: C6C8D14D-651B-577D-990C-B7F436758C3D; Taxon: scientificName: Lenomyrmex inusitatus; kingdom: Animalia; phylum: Arthropoda; class: Insecta; order: Hymenoptera; family: Formicidae; genus: Lenomyrmex; specificEpithet: inusitatus; scientificNameAuthorship: (Fernández, 2001); Location: continent: South America; country: Colombia; countryCode: CO; stateProvince: Caquetá; county: Florencia; locality: Av. Caraño, Vía Florencia-Suaza; verbatimElevation: 1375 m; locationRemarks: Collected in leaf Litter; verbatimCoordinates: 01°42'34.3"N 75°43'5.9"W; verbatimCoordinateSystem: WGS 84; Event: samplingProtocol: Winkler; eventDate: 2023-09-30; Record Level: language: es; collectionID: RNC: 270; institutionCode: Universidad de la Amazonia (UDLA); basisOfRecord: PreservedSpecimen
Diagnosis
This species can be recognised by its mesosoma smooth and shiny, with no erect hairs; propodeum with a pair of acute and well-defined spines; head foveolate, with median longitudinal striae (Fig. 11) (Fernández and Serna 2019).
Distribution
This is the first record of the genus and species for the Amazon Region. The species was previously known from southern Colombia (Delsinne and Fernández 2011) and Ecuador (Salazar et al. 2015). This finding highlights the importance of studying ants in transition zones, as valuable information can be obtained about the distribution of species considered primarily Andean.
Biology
Unusual species, rarely collected. According to Delsinne and Fernández (2011), L. inusitatus inhabits mainly leaf litter and modified mandibles may be related to their being specialised hunter ants, although their prey is not known.
description: Published as part of Arredondo, Brandon S., Carreño-Guevara, Yennifer, Gutierrez-Villanueva, Yenifer, Duran-Bautista, Ervin Humprey, Gamboa-Tabares, Jean & Guerrero, Roberto J., 2025, Soil and leaf litter ants from the Amazon Region offer new distribution records for Colombia, pp. e 142813 in Biodiversity Data Journal 13 on page e142813, DOI: 10.3897/BDJ.13.e142813
S1 Table Information on the full statistical models, including fixed and random effects
Creators: name: Baumgartner, Sabine A.
name: Smith, Stuart W.
name: Bartzke, Gundula S.
name: Laizar, Oloshiro
name: Ploechl, Jane
name: Michler, Lena
name: Naro, Elizabeth
name: Treydte, Anna C
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 410199
subject: Climate change impacts and adaptation not elsewhere classified
classificationCode: 410404
subject: Environmental management

description: Seven linear and generalized linear mixed-effects mixed models per growing period were applied to analyze the effect of the fixed factors ‘rangeland area’ (Alalili vs. DryRL vs. RainRL), ‘herbivory’ (fenced vs. grazed), and ‘clipping frequency’ (monthly vs. seasonally clipped), and the two way- interaction of the fixed factors on the dependent variables ‘grass biomass’ and ‘forb biomass’, ‘grass regrowth’ and ‘forb regrowth’, ‘grass cover’, ‘forb cover’ and the ‘proportion of bare ground’ respectively. To account for repeated measurements from the same site, block and quadrat, we nested ‘quadrat’ in ‘block’ in ‘site’, and included them in the model as nested random factors.The above described full model structure was used for all models. For a detailed description of the statistical analyses, please read the related manuscript.
Phytochemical composition of commiphora oleogum resins and their cytotoxicity against skin cancer cells
Creators: name: Ulrich, Judith
name: Stiltz, Svenja
name: St-Gelais, Alexis
name: El Gaafary, Menna
name: Simmet, Thomas
name: Syrovets, Tatiana
name: Schmiech, Michael
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Guggul
subject: Guggulsterone
subject: DDC 610 / Medicine & health
subject: Skin; Cancer
subject: Medicinal plants
subject: Myrrh
subject: Terpenoids
subject: Plants, Medicinal
subject: Skin neoplasms
subject: Commiphora
subject: Terpenes

description: Oleogum resins of the genus Commiphora have been used in traditional medicines for centuries. More than 200 Commiphora species exhibit highly variable phytochemical compositions. A novel highly selective, sensitive, accurate HPLC-MS/MS method was developed and validated to quantify five characteristic phytosteroids and furanosesquiterpenoids, namely (E)-guggulsterone, (Z)-guggulsterone, curzerenone, furanoeudesma-1,3-diene, and myrrhone. The resulting contents and additionally GC analysis were used to classify and differentiate Commiphora oleogum resins of the species C. myrrha, C. erythraea, C. mukul, C. holtziana, C. confusa, and C. kua, as well as unspecified resins. Interestingly, a Commiphora sample from Ogaden, Ethiopia, comprised 446 ng/mg guggulsterones presumed to be unique to C. mukul from the Indian subcontinent. However, Commiphora from Ogaden differed considerably from C. mukul in respect to guggulsterones isomer’s ratio. Moreover, the cytotoxicity of Commiphora extracts, essential oils, botanical drugs containing Commiphora, and pure compounds against the epidermoid carcinoma A431, malignant melanoma RPMI-7951 and SK-MEL-28 cells was investigated in vitro. Thereby, especially C. mukul extract and C. myrrha essential oil exhibited high cytotoxicity against skin cancer cells with IC50 of 2.9–10.9 µg/mL, but were less toxic to normal keratinocytes. In summary, Commiphora oleogum resins and its phytochemicals warrant further investigation aiming at chemotaxonomical classification as well as application in skin cancer treatment.