cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Myocardial Infarction Subtypes in Patients With Type 2 Diabetes Mellitus and the Effect of Liraglutide Therapy (from the LEADER Trial)
Creators: name: Marso, S.P.
name: Treppendahl, M.B.
name: Buse, J.B.
name: LEADER Publication Committee on behalf of the LEADER Trial Investigators
name: Nauck, M.A.
name: Monk Fries, T.
name: Rasmussen, S.
Publisher: name: Elsevier Inc.
Year: 2018

description: Diabetes mellitus (DM) is a known risk factor for myocardial infarction (MI); however, data regarding MI subtypes in people with diabetes are limited. In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial (n = 9,340), liraglutide significantly reduced the risk of major adverse cardiovascular (CV) events (composite of CV death, nonfatal MI, or nonfatal stroke) versus placebo in patients with type 2 DM and high CV risk. Liraglutide also reduced risk of first MI (292 events with liraglutide vs 339 with placebo). This post hoc analysis characterized MIs (first and recurrent) occurring in LEADER, by treatment arm and regarding incidence, outcome, subtype, and troponin levels. A total of 780 MIs (first and recurrent) were reported, with fewer in the liraglutide-treatment group than in the placebo-treatment group (359 vs 421, p = 0.022). Numerically fewer MIs were associated with CV death with liraglutide than with placebo (17 vs 28 fatal MIs, p = 0.28). Symptomatic MIs in both arms were mainly non–ST-segment elevation MI (555/641) and spontaneous MI (518/641). Numerically greater proportions of symptomatic MIs were associated with troponin levels ≤5× or ≤10× the upper reference limit with liraglutide versus placebo (p = 0.16 and p = 0.42, respectively). At baseline, more liraglutide-treated patients than placebo-treated patients with MI during the trial had a history of coronary artery bypass graft (p = 0.008), and fewer had peripheral arterial disease in the lower extremities (p = 0.005) and >50% stenosis of the coronary artery, the carotid artery, or other arteries (p = 0.044). In conclusion, this analysis showed that liraglutide reduces the incidence of MIs in patients with type 2 DM at high CV risk and may impact the clinical outcomes of MI.
Hypertension Control in Adults with Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin
Creators: name: Standl, E.
name: Holman, R.R.
name: Armstrong, P.W.
name: Van De Werf, F.
name: Navar, A.M.
name: Gallup, D.S.
name: Lachin, J.M.
name: McGuire, D.K.
name: Buse, J.B.
name: Engel, S.S.
name: Green, J.B.
name: Lokhnygina, Y.
name: Peterson, E.D.
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Systolic blood pressure (SBP) treatment targets for adults with diabetes mellitus remain unclear. SBP levels among 12 275 adults with diabetes mellitus, prior cardiovascular disease, and treated hypertension were evaluated in the TECOS (Trial Evaluating Cardiovascular Outcomes With Sitagliptin) randomized trial of sitagliptin versus placebo. The association between baseline SBP and recurrent cardiovascular disease was evaluated using multivariable Cox proportional hazards modeling with restricted cubic splines, adjusting for clinical characteristics. Kaplan-Meier curves by baseline SBP were created to assess time to cardiovascular disease and 2 potential hypotension-related adverse events: worsening kidney function and fractures. The association between time-updated SBP and outcomes was examined using multivariable Cox proportional hazards models. Overall, 42.2% of adults with diabetes mellitus, cardiovascular disease, and hypertension had an SBP ≥140 mm Hg. The association between SBP and cardiovascular disease risk was U shaped, with a nadir ≈130 mm Hg. When the analysis was restricted to those with baseline SBP of 110 to 150 mm Hg, the adjusted association between SBP and cardiovascular disease risk was flat (hazard ratio per 10-mm Hg increase, 0.96; 95% confidence interval, 0.91-1.02). There was no association between SBP and risk of fracture. Above 150 mm Hg, higher SBP was associated with increasing risk of worsening kidney function (hazard ratio per 10-mm Hg increase, 1.10; 95% confidence interval, 1.02-1.18). Many patients with diabetes mellitus have uncontrolled hypertension. The U-shaped association between SBP and cardiovascular disease events was largely driven by those with very high or low SBP, with no difference in cardiovascular disease risk between 110 and 150 mm Hg. Lower SBP was not associated with higher risks of fractures or worsening kidney function.
การจัดการเรียนรู้สืบเสาะแบบมีการโต้แย้งในปฏิบัติการรายวิชาเคมี ที่มีต่อการโต้แย้งทางวิทยาศาสตร์ของนักเรียนชั้นมัธยมศึกษาปีที่ 5
Creators: name: ภาวิณี จันทร์หอม
Publisher: name: Walailak University
Year: 2019
Subjects: การโต้แย้งทางวิทยาศาสตร์
ปฏิบัติการเคมี
การเรียนรู้แบบสืบเสาะ

description: วารสารนวัตกรรมการเรียนรู้ มหาวิทยาลัยวลัยลักษณ์, 5, 1, 21-38
(101357) William Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การประเมินผลของการสืบเสาะหาความรู้โดยใช้แบบจำลองเป็นฐานร่วมกับการใช้การเชื่อมโยงหลักฐานและแบบจำลองที่มีต่อการอธิบายทางวิทยาศาสตร์เรื่องสารละลาย อิเล็กโทรไลต์และนอนอิเล็กโทรไลต์ของนักเรียนชั้นมัธยมศึกษาปีที่ 5
Creators: name: พรรณนภา อนิวรรตนวงศ์
Publisher: name: Walailak University
Year: 2019
Subjects: การสืบเสาะหาความรู้โดยใช้แบบจำลองเป็นฐาน
การใช้การเชื่อมโยงหลักฐานและแบบจำลอง และความสามารถในการอธิบายทางวิทยาศาสตร์

description: วารสารนวัตกรรมการเรียนรู้ มหาวิทยาลัยวลัยลักษณ์, 5, 1, 65-83
title: Endovascular stroke treatment: an up-to-date review
Creators: name: Fatania, Gavin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: Interventional vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: Thrombolysis
subject: Arterial access
subject: Recanalisation
subject: Embolism / Thrombosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Since 2015 there has been mounting class Ia evidence that mechanical thrombectomy is superior to thrombolysis alonefor acute ischaemic stroke. We provide a review of this evidence to update clinical practice and demonstrate the subgroups for which...
In reply
Creators: name: Buse, J.B.
name: Young, L.A.
name: Donahue, K.E.
Publisher: name: American Medical Association
Year: 2017

description: In Reply We thank Pimazoni-Netto et al for their letter and include our response to their concerns. In considering our published results, it is of tantamount importance that readers understand the tenets of comparative effectiveness research (CER).
Glucose self-monitoring in non-insulin-treated patients with type 2 diabetes in primary care settings: A randomized trial
Creators: name: Weaver, M.A.
name: Buse, J.B.
name: Grimm, K.
name: Blakeney, T.
name: Vu, M.B.
name: Mitchell, C.M.
name: Rees, J.
name: Niblock, F.
name: Donahue, K.E.
name: Young, L.A.
Publisher: name: American Medical Association
Year: 2017

description: IMPORTANCE The value of self-monitoring of blood glucose (SMBG) levels in patients with non-insulin-treated type 2 diabetes has been debated. OBJECTIVE To compare 3 approaches of SMBG for effects on hemoglobin A1c levels and health-related quality of life (HRQOL) among people with non-insulin-treated type 2 diabetes in primary care practice. DESIGN, SETTING, AND PARTICIPANTS The Monitor Trial studywas a pragmatic, open-label randomized trial conducted in 15 primary care practices in central North Carolina. Participants were randomized between January 2014 and July 2015. Eligible patients with type 2 non-insulin-treated diabetes were: older than 30 years, established with a primary care physician at a participating practice, had glycemic control (hemoglobin A1c) levels higher than 6.5%but lower than 9.5%within the 6 months preceding screening, as obtained from the electronic medical record, and willing to comply with the results of random assignment into a study group. Of the 1032 assessed for eligibility, 450 were randomized. INTERVENTIONS No SMBG, once-daily SMBG, and once-daily SMBG with enhanced patient feedback including automatic tailored messages delivered via the meter. MAIN OUTCOMES AND MEASURES Coprimary outcomes included hemoglobin A1c levels and HRQOL at 52 weeks. RESULTS A total of 450 patients were randomized and 418 (92.9%) completed the final visit. There were no significant differences in hemoglobin A1c levels across all 3 groups (P = .74; estimated adjusted mean hemoglobin A1c difference, SMBG with messaging vs no SMBG, -0.09%; 95%CI, -0.31% to 0.14%; SMBG vs no SMBG, -0.05%; 95%CI, -0.27%to 0.17%). There were also no significant differences found in HRQOL. There were no notable differences in key adverse events including hypoglycemia frequency, health care utilization, or insulin initiation. CONCLUSIONS AND RELEVANCE In patients with non-insulin-treated type 2 diabetes, we observed no clinically or statistically significant differences at 1 year in glycemic control or HRQOL between patients who performed SMBG compared with those who did not perform SMBG. The addition of this type of tailored feedback provided through messaging via ameter did not provide any advantage in glycemic control.
Revisão de Escopo
Creators: name: Da Silva, Danilo Oliveira
name: Cleonice Andrea  Alves Cavalcante
name: Soares, Aylanne Maria Lopes
name: Monteiro, Jéssica Selena Ferreira
name: FARIAS, ERICA RAYANE GALVAO DE
name: ANTÔNIA DANIELLY MOURA DE SOUZA
name: De Melo, Adriana Cristina Aires
Publisher: name: OSF
Year: 2021

description: identificar e mapear nos bancos de dados e na literatura cinzenta os conhecimentos, atitudes e práticas assistenciais em saúde perpassam o cuidado seguro em vacinação na criança.
Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia
Creators: name: Zhang, Y.
name: Wang, J.
name: Kahkoska, A.R.
name: Sun, W.
name: Yu, J.
name: Gu, Z.
name: Buse, J.B.
Publisher: name: Wiley-VCH Verlag
Year: 2017

description: Hypoglycemia, the state of abnormally low blood glucose level, is an acute complication of insulin and sulfonylurea therapy in diabetes management. Frequent insulin dosing and boluses during daily diabetes care leads to an increased risk of dangerously low glucose levels, which can cause behavioral and cognitive disturbance, seizure, coma, and even death. This study reports an insulin-responsive glucagon delivery method based on a microneedle (MN)-array patch for the prevention of hypoglycemia. The controlled release of glucagon is achieved in response to elevated insulin concentration by taking advantage of the specific interaction between insulin aptamer and target insulin. Integrating a painless MN-array patch, it is demonstrated that this insulin-triggered glucagon delivery device is able to prevent hypoglycemia following a high-dose insulin injection in a chemically induced type 1 diabetic mouse model.
Hunting for red supergiant binary systems in the ultra-violet
Creators: name: Patrick, Lee Robert
Publisher: name: Zenodo
Year: 2022
Subjects: red supergiant stars
binary stars
Small Magellanic Cloud

description: Massive stars are uniquely important cosmic engines and are responsible for the production of gravitational wave progenitors. Throughout their lives - via intense stellar winds - and as they die - via core-collapse supernova explosions - massive stars shape their chemical and kinematic environment. The effects of binary evolution and interactions are one of the major uncertainties in our understanding of the lives of massive stars and predicting their endpoints. This is particularly true of the red supergiant (RSG) phase of evolution: the final evolutionary phase before supernova for the majority of massive stars. The new, high-spatial resolution, UltraViolet Imaging Telescope survey of the Magellanic Clouds provides a unique method to identify and characterise RSG binary systems where the - normally dominant - RSG star is extremely faint. We present our first results in the Small Magellanic Cloud, where we examine the binary nature of over 500 RSGs and determine the initial binary fraction of SMC RSGs to be 18.8 ± 1.5%. Stellar parameters for both components are determined and the mass-ratio distribution of the SMC RSG binary population is studied. We place these results in an evolutionary context by comparing with multiplicity statistics at different evolutionary phases.
description: Full details see Patrick et al. 2022, MNRAS, 513, 5847. For a more detailed summary see Patrick et al. 2022, IAUS361 article
title: Sarcopenia is an independent prognostic factor for poor overall survival among patients with pancreatic adenocarcinoma
Creators: name: Lambert, Aurélien
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: CT
subject: Pancreas
subject: Oncology
subject: Abdomen
subject: Metabolic disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Only a few major improvements have been made to predict overall survival of patients with pancreatic cancer. We aimed to evaluate sarcopenia as an independent prognostic factor for overall survival to predict early relapses or progressive disease...
Editora de Magás
Creators: name: Goulart, Izabella
name: Jamilly Maria
name: Gomes, Marizangela
Publisher: name: Zenodo
Year: 2022
Subjects: Planejamento estratégico
Administração
Atendimento ao cliente

description: Orientação aos estudantes da disciplina de Administração de Biblioteca na construção do planejamento estratégico, para a elaboração de um projeto de empreendedorismo.
title: Computed tomography imaging in the assessment of laryngeal cancers
Creators: name: Ezzedine, Ekbel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Anatomy
subject: Ear / Nose / Throat
subject: Oncology
subject: CT
subject: Diagnostic procedure
subject: Staging
subject: Cancer
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize CT findings of the normal anatomy of the laryngeal region. To approach how to identify the different imaging appearance of the laryngeal cancer and its therapeutic involvement depending on the TNM...
การพัฒนาผลสัมฤทธิ์ทางการเรียนเรื่อง ชนิดของประโยค ระดับชั้นมัธยมศึกษาปีที่ 2 โดยใช้การจัดการเรียนรู้แบบใช้โครงงานเป็นฐาน
Creators: name: อัญญาณี  มุ่งพิงกลาง
Publisher: name: Walailak University
Year: 2019
Subjects: การจัดการเรียนรู้แบบโครงงานเป็นฐาน
ชนิดของประโยค

description: วารสารนวัตกรรมการเรียนรู้ มหาวิทยาลัยวลัยลักษณ์, 5, 1, 85-100
title: A computed tomography-crossing of peritoneum from normal to pathological
Creators: name: Ali, Amal
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Pelvis
subject: Anatomy
subject: CT
subject: Computer Applications-Detection, diagnosis
subject: Inflammation
subject: Infection
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize CT findings of the normal anatomy of peritoneum. To approach how to identify the different imaging appearance of primary or secondary pathological changes of the...
title: Thoracic HRCT Terminology, Pictorial Review
Creators: name: Musanhu, Ed
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cysts
subject: Cavitation
subject: Education
subject: CT-High Resolution
subject: CT
subject: Respiratory system
subject: Lung

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recognise the radiological HRCT featuresthat correspond toeach particular term Know how to distinguish between some of the closely related radiological findings Know the common differentials for each...
(101355) Charles Thornton Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery
Creators: name: Buse, J.B.
name: Zhang, Y.
name: Qian, C.
name: Zhu, Y.
name: Ligler, F.S.
name: Cui, Z.
name: Gu, Z.
name: Shen, Q.
name: Yu, J.
Publisher: name: American Chemical Society
Year: 2017

description: A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme. Moreover, the d-GRPs were able to eliminate the excess H2O2, which may lead to free radical-induced damage to skin tissue during the long-term usage and reduce the activity of GOx. In vivo experiments indicated that this smart insulin patch could efficiently regulate the blood glucose in the chemically induced type 1 diabetic mice for 10 h.
title: Down a swallow! A compendium of oesophageal fluoroscopic imaging for the trainee and general radiologist.
Creators: name: Zammit, Lara Maria
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Swallowing disorders
subject: Motility
subject: Cancer
subject: Education
subject: Dynamic swallowing studies
subject: Barium meal
subject: Fluoroscopy
subject: Stomach (incl. Oesophagus)
subject: Gastrointestinal tract
subject: Contrast agents

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate the tell-tale signs of common oesophageal pathologies and motility disorders using uppergastrointestinal (GI)dynamicfluoroscopic studies To be aware of expectant post-upper GI surgery findings on fluoroscopic examinations To serve as...
No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase-4 inhibitors vs therapeutic alternatives
Creators: name: Jonsson Funk, M.
name: Stürmer, T.
name: Gokhale, M.
name: Lund, J.
name: Buse, J.B.
name: Simpson, R.J.
name: Pate, V.
Publisher: name: Blackwell Publishing Ltd
Year: 2017

description: Aim: To compare the cardiovascular (CV) risk associated with dipeptidyl peptidase-4 (DPP-4) inhibitors relative to sulphonylureas (SUs) and thiazolidinediones (TZDs). Methods: During 2007 to 2013, using Medicare data for beneficiaries aged >65 years, we identified the following 2 cohorts of new-users, who had not been exposed to the drugs being compared in the 6 months before initiation: (1) DPP-4 inhibitor vs SU initiators and (2) DPP-4 inhibitor vs TZD initiators. Using propensity-score-adjusted Cox models accounting for competing risk by death, we estimated the hazard ratios (HRs), risk differences and 95% confidence intervals (CIs) for myocardial infarction (MI), stroke, hospitalization for heart failure (HF), and a combined outcome (MI, stroke, all-cause mortality). Results: In the DPP-4 inhibitor vs SU comparison, there were 30 130 DPP-4 inhibitor initiators and 68 382 SU initiators. Their mean age was 75 years, 41% were men and 55% had a baseline CV condition. The HR for the composite outcome was 0.75 (95% CI 0.72-0.79) over a median treatment duration of 1 year, but the 1-year risks of MI were 1.00 (95% CI 0.89-1.12) and 1.47 (95% CI 1.38-1.56) per 100 patients for DPP-4 inhibitors and SUs, respectively, and the corresponding stroke risks were 0.98 (95% CI 0.87-1.10) and 1.09 (95% CI 1.01-1.17). For the DPP-4 inhibitor vs TZD comparison, there were 20 596 DPP-4 inhibitor initiators and 13 526 TZD initiators without previous HF. Their mean age was 74 years, 42% were men and 30% had a baseline CV event. The composite outcome HR was 0.94 (95% CI 0.86-1.02) over a median treatment duration of 1 year. The 1-year risk for MI was ~0.90 and for stroke it was ~0.80 per 100 patients in both DPP-4 inhibitor and TZD initiators. Conclusion: Although limited by the short treatment period, the present study suggests there is no increased short-term risk of MI, stroke or HF with DPP-4 inhibitors vs SUs/TZDs.
The extraction of work from quantum coherence
Creators: name: Korzekwa, Kamil
name: Lostaglio, Matteo
name: Oppenheim, Jonathan
name: Jennings, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The interplay between quantum-mechanical properties, such as coherence, and classical notions, such as energy, is a subtle topic at the forefront of quantum thermodynamics. The traditional Carnot argument limits the conversion of heat to work; here we critically assess the problem of converting coherence to work. Through a careful account of all resources involved in the thermodynamic transformations within a fully quantum-mechanical treatment, we show that there exist thermal machines extracting work from coherence arbitrarily well. Such machines only need to act on individual copies of a state and can be reused. On the other hand, we show that for any thermal machine with finite resources not all the coherence of a state can be extracted as work. However, even bounded thermal machines can be reused infinitely many times in the process of work extraction from coherence.
description: 15 pages, 4 figures. Published version. Improved and expanded discussion
Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial
Creators: name: Buse, J.B.
name: Westerhout, C.M.
name: Rodbard, H.W.
name: Armstrong, P.W.
name: Kaufman, K.D.
name: TECOS Study Group
name: Green, J.B.
name: Majumdar, S.R.
name: Holman, R.R.
name: Adler, A.
name: Peterson, E.D.
name: Bethel, M.A.
name: Zheng, Y.
name: Josse, R.G.
name: Tankova, T.
Publisher: name: Blackwell Publishing Ltd
Year: 2017

description: Aim: To examine fracture incidence among participants in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). Research design and methods: We used data from 14 671 participants in the TECOS study who were randomized double-blind to sitagliptin (n = 7332) or placebo (n = 7339). Cumulative fracture incidence rates were calculated and their association with study treatment assignment was examined using multivariable Cox proportional hazards regression. Results: The baseline mean (standard deviation) participant age was 65.5 (8.0) years, diabetes duration was 11.6 (8.1) years and glycated haemoglobin level was 7.2 (0.5)% [55.2 (5.5) mmol/mol], and 29.3% of participants were women and 32.1% were non-white. During 43 222 person-years’ follow-up, 375 (2.6%; 8.7 per 1000 person-years) had a fracture; 146 were major osteoporotic fractures (hip, n = 34; upper extremity, n = 81; and clinical spine, n = 31). Adjusted analyses showed fracture risk increased independently with older age (P <.001), female sex (P <.001), white race (P <.001), lower diastolic blood pressure (P <.001) and diabetic neuropathy (P =.003). Sitagliptin, compared with placebo, was not associated with a higher fracture risk [189 vs 186 incident fractures: unadjusted hazard ratio (HR) 1.01, 95% confidence interval (CI) 0.82 to 1.23, P =.944; adjusted HR 1.03, P =.745], major osteoporotic fractures (P =.673) or hip fractures (P =.761). Insulin therapy was associated with a higher fracture risk (HR 1.40, 95% CI 1.02-1.91; P =.035), and metformin with a lower risk (HR 0.76, 95% CI 0.59-0.98; P =.035). Conclusion: Fractures were common among people with diabetes in the TECOS study, but were not related to sitagliptin therapy. Insulin and metformin treatment were associated with higher and lower fracture risks, respectively.
DENR Nutrient Management Plans (Part 4)
Creators: name: The University Of North Carolina At Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: PDFs of scanned or electronically delivered Nutrient Management Plans (NMPs) from the Department of Environment and Natural Resources (DENR) in summer 2014 during their five-year review and re-permitting of most of NC swine CAFOs (industrial animal operations/factory farms/concentrated animal feeding operations). Swine CAFOs take the manure that pigs produce and store it in open-air pits called lagoons and then spray the liquid effluent onto what are called sprayfields as fertilizer for crops. The data includes almost all of the NMPs for all swine CAFOs, all the sprayfields for Duplin county only, lagoons for Duplin and Sampson counties only, and the corrected point location of the swine CAFO for Duplin county only. NC DENR has publicly available all point locations of swine CAFOs, but sometimes they are wrong. Provided here are correct point locations of the swine CAFO for Duplin county. Every sprayfield, lagoon, and point have the permit ID associated with them that can be used to link the three files together. Please see DENR Nutrient Management Plans--Supplemental Files for shapefiles and other contextual data tables.
(101305) James Bawden Born
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Logística, Rede, Cadeia de Suprimentos e Serviços em Empreendimentos Turísticos e Eventos I
Creators: name: Gomes, Marizangela
Publisher: name: Zenodo
Year: 2022
Subjects: Logística Empresarial
Gerenciamento
Ergonomia
Antropometria

description: Material elaborado para a disciplina "Administração de Unidades de Informação".
title: Congenital anomalies and variants of the aortic arch. A pictorial essay based on an embriological model.
Creators: name: Trujillo Calderon, Nasly
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Congenital
subject: Screening
subject: Barium meal
subject: MR
subject: Digital radiography
subject: CT
subject: Paediatric
subject: Cardiovascular system
subject: Cardiac

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: LEARNING OBJECTIVES To present an embriological model (The Edwards model) as a useful tool to understand the morfology as well as manifestations of most congenital anomalies and variants of the aortic arch. To describe the radiologic features and...
Differential Use of Screening Mammography in Older Women Initiating Metformin versus Sulfonylurea
Creators: name: Buse, J.B.
name: Stürmer, T.
name: Hong, J.-L.
name: Jonsson Funk, M.
name: Henderson, L.M.
name: Lund, J.L.
name: Pate, V.
Publisher: name: John Wiley and Sons Ltd
Year: 2017

description: Purpose: Differential use of screening mammography may lead to biased detection of breast cancer. This study aimed to compare receipt of screening mammography and the incidence of screen-detected breast cancer between metformin and sulfonylurea initiators. Methods: We used 2006-2014 US Medicare claims to identify initiators of metformin or sulfonylurea aged 65+ years continuously enrolled in Parts A/B for ≥2 years pre-initiation and ≥2 years post-initiation. We reported frequencies of screening mammograms and screen-detected breast cancer in 1 year pre-initiation among all cohort members and in 1 year post-initiation among cancer-free cohort members. Weighted screening risk differences (RDs) were estimated comparing metformin to sulfonylurea group. Results: We identified 41,436 and 13,367 initiators of metformin and sulfonylurea, 35% and 24% of which had ≥1 screening mammogram in 1 year pre-initiation (weighted RD: 6 percentage points; 95% CI: 5 to 7), respectively. The weighted RD for screen-detected breast cancer associated with metformin was 0.00 percentage points (95% CI: -0.09 to 0.09). Among cancer-free cohort members, metformin initiators had 5 percentage points (95% CI: 4 to 6) and 0.11 percentage points (95% CI: -0.02 to 0.23) absolute risk excess of screening mammography and screen-detected breast cancer in 1 year post-initiation, compared with sulfonylurea initiators, respectively. Conclusions: Metformin initiators were more likely to receive screening mammograms than sulfonylurea initiators pre- and post-initiation, indicating possible detection bias due to differential screening mammography. Researchers should be aware of the potential for more screening mammograms pre- and post-initiation when interpreting the findings of metformin on breast cancer incidence.
Observing type I AGN around Cosmic Noon with ELT/HARMONI
Creators: name: Lorenzo, Begoña García
name: Monreal-Ibero, Ana
name: Donaji Esparza-Arredondo
name: Dametto, Natacha Zanon
Publisher: name: Zenodo
Year: 2022
Subjects: quasars: general – galaxies: kinematics and dynamics – instrumentation: high angular resolution – instrumentation: spectrographs

description: The incoming generation of the 30-40 meter-class telescopes will enable resolving the stellar kinematics of high redshift galaxies. In particular, the High Angular Resolution Monolithic Optical and Near-infrared Integral field spectrograph (HARMONI) for the Extremely Large Telescope (ELT) could likely resolve the stellar kinematics of galaxies around cosmic noon with similar spatial and velocity resolutions to current studies for nearby and intermediate redshift galaxies. We have simulated HARMONI observations of type I AGNs at redshift 1.5, using the 20x20 mas2 spatial scale and LTAO working at 0’’.67 seeing. We used MUSE observations of a nearby galaxy to create the input targets for the HARMONI simulation pipeline (HSIM). In this work, we present the results of these simulations highlighting the capabilities of HARMONI to unveil the stellar morpho-kinematic properties of type I AGNs around cosmic noon, performing a de-blending of the AGN and host galaxy spectra.
description: This work is part of the Participation of the Instituto de Astrofísica de Canarias in the development of the HARMONI instrument for the Extremely Large Telescope. See HARMONI at the IAC (https://www.iac.es/es/proyectos/harmoni)
title: Computed tomography (CT) evaluation of the brain abnormalities found in children with microcephaly in association with Zika Virus, accompanied by Instituto de Medicina Integral Professor Fernando Figueira
Creators: name: Melo, Adriana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tropical diseases
subject: Outcomes
subject: Epidemiology
subject: Statistics
subject: Socio-economic issues
subject: Efficacy studies
subject: CT
subject: Paediatric
subject: Neuroradiology brain
subject: Head and neck

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - To demonstrate the head CT findings of 20 children with congenital microcephaly, accompanied by Instituto de Medicina Integral Professor Fernando Figueira, whose mothers had clinical and epidemiological period consistent with infection by Zika...
Comparative effect of initiating metformin versus sulfonylureas on breast cancer risk in older women
Creators: name: Buse, J.B.
name: Pate, V.
name: Funk, M.J.
name: Henderson, L.M.
name: Hong, J.-L.
name: Stürmer, T.
name: Lund, J.L.
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Background: Several observational studies have reported that metformin may be associated with reduced risk of breast cancer
description: however, many of these studies were affected by time-related biases such as immortal time bias and time-window bias. This study aimed to examine the relative risk of breast cancer for older women initiating metformin versus sulfonylureas while avoiding such biases. Methods: The study cohort consisted of women aged 65+ who initiated monotherapy with metformin (n = 45,900) or sulfonylureas (n = 13,904) and were free of cancer and renal disease within 6 months before treatment initiation using 2007-2012 US Medicare claims data. We followed treatment initiators for incident breast cancer, and estimated hazard ratios using weighted Cox models. Unmeasured confounding by body mass index and smoking was further adjusted by propensity score calibration using external information from Medicare Current Beneficiary Survey 2006-2009 panels. Results: During 58,835 and 16,366 person-years of follow-up, 385 initiators of metformin treatment and 95 of sulfonylurea were diagnosed with breast cancer. Metformin initiators did not have a reduced risk of breast cancer compared with sulfonylurea initiators (hazard ratio: 1.2
description: 95% confidence interval: 0.94, 1.6). Externally controlling for body mass index and smoking did not affect the estimates. Conclusion: The findings of this study provide no support for a reduced risk of breast cancer after initiation of metformin compared with a clinical alternative in older women. This study is limited by the relatively short follow-up time and we cannot exclude the possible benefits of long-Time metformin use on breast cancer risk.
Red Blood Cells for Glucose-Responsive Insulin Delivery
Creators: name: Buse, J.B.
name: Wang, J.
name: Ye, Y.
name: Gu, Z.
name: Yu, J.
name: Lawrence, D.S.
name: Sun, W.
name: Wang, C.
Publisher: name: Wiley-VCH Verlag
Year: 2017

description: Glucose-responsive delivery of insulin mimicking the function of pancreatic β-cells to achieve meticulous control of blood glucose (BG) would revolutionize diabetes care. Here the authors report the development of a new glucose-responsive insulin delivery system based on the potential interaction between the glucose derivative-modified insulin (Glc-Insulin) and glucose transporters on erythrocytes (or red blood cells, RBCs) membrane. After being conjugated with the glucosamine, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. The delivery vehicle can be further simplified utilizing injectable polymeric nanocarriers coated with RBC membrane and loaded with Glc-Insulin. The described work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness.
There was a star-forming galaxy that was quenched
Creators: name: Pérez-Millán, David
name: Fritz, Jacopo
name: González-Lopezlira, Rosa A.
Publisher: name: Zenodo
Year: 2022
Subjects: Galaxy evolution
Star formation history
Cluster galaxies

description: Cluster galaxies are subject to a whole range of processes and interactions that dramatically change their properties. To shed light on these issues, we analyze the most homogeneous and complete local cluster galaxy survey to date: WINGS/OmegaWINGS, and use stellar population synthesis techniques to obtain properties such as stellar mass, stellar ages, SFR, and SFH. Our results show that, although the cluster environment eventually shuts off the star formation, some mechanisms might instead enhance it temporarily, i.e., ram pressure and close encounters with other galaxies. In this picture, it is crucial to take morphology into account: while cluster spirals do follow the main sequence, early types still display some level of star formation, likely triggered by hydrodynamic interactions with other galaxies. Finally, the local environment dominates the stellar evolution, while the global cluster is likely a secondary agent.
Metformin use may moderate the effect of DPP-4 inhibitors on cardiovascular outcomes
Creators: name: Williams, J.W., Jr.
name: Buse, J.B.
name: D'Alessio, D.A.
name: Crowley, M.J.
name: Kosinski, A.S.
Publisher: name: American Diabetes Association Inc.
Year: 2017

description: Objective: To explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i). Research Design and Methods: We performed a meta-analysis of the three major cardiovascular outcomes trials examining DPP-4i. We used meta-regression to examine how the cardiovascular effects of DPP-4i differ between prevalent metformin users and baseline nonusers. Results: While prevalent metformin users experienced a trend toward improved cardiovascular outcomes with DPP-4i (summary hazard ratio [HR] 0.92 [95% CI 0.84, 1.01]), baseline metformin nonusers showed a trend toward harm(HR 1.10 [95% CI 0.97, 1.26]). The difference in overall DPP-4i effect between metformin user and nonuser subgroups was statistically significant (P = 0.036). Conclusions: Baseline metformin status may have a moderating effect on cardiovascular outcomes with DPP-4i use. This hypothesis-generating analysis suggests there is residual uncertainty as to how DPP-4i affect cardiovascular outcomes, depending on concurrently prescribed medications.
การศึกษาความสัมพันธ์ระหว่างการค้าหาบเร่แผงลอยกับลักษณะเชิงพื้นที่ของเมือง กรณีศึกษา: ย่านรามคำแหง กรุงเทพมหานคร
Creators: name: ณัฐพงศ์ เปรมพูลสวัสดิ์
Publisher: name: Thammasat Printing House
Year: 2018
Subjects: การค้าหาบเร่แผงลอย
เศรษฐกิจนอกระบบ
พื้นที่สาธารณะ
ย่านรามคำแหง
กรุงเทพมหานคร

description: Journal of Architectural/Planning Research and Studies, 15, 2, 1-16
ภูมิศาสตร์วรรณยุกต์ภาษาไทยวนในภูมิภาคเอเชียตะวันออกเฉียงใต้
Creators: name: สิริวรรณพิชา  ธนจิราวัฒน์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2019
Subjects: ไทยวน
วรรณยุกต์
วรรณยุกต์ไทยวน
ภูมิศาสตร์วรรณยุกต์
ภูมิศาสตร์วรรณยุกต์ไทยวน

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 19, 1, 79-106
(101300) Susannah Haythorne Latcham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Positioning Students in the International Intercultural Classroom: An Exploration of English Teachers' Discourse
Creators: name: Loo, D.B.
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2019
Subjects: Discursive Positioning
Intercultural Communicative Competence
Non-Local English Teachers
Pronominal Markers

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 19, 1, 107-139
Ophelia: Neither a Green Girl Nor a Wanton Woman
Creators: name: Pattarakulvanit, C.
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2019
Subjects: Shakespeare
Ophelia
Madness
Patriarchy
resistance

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 19, 1, 160-168
Thermal Diagnostics with the Atmospheric Imaging Assembly onboard the Solar Dynamics Observatory: A Validated Method for Differential Emission Measure Inversions
Creators: name: Cheung, Mark C. M.
name: Boerner, P.
name: Schrijver, C. J.
name: Testa, P.
name: Chen, F.
name: Peter, H.
name: Malanushenko, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present a new method for performing differential emission measure (DEM) inversions on narrow-band EUV images from the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO). The method yields positive definite DEM solutions by solving a linear program. This method has been validated against a diverse set of thermal models of varying complexity and realism. These include (1) idealized gaussian DEM distributions, (2) 3D models of NOAA Active Region 11158 comprising quasi-steady loop atmospheres in a non-linear force-free field, and (3) thermodynamic models from a fully-compressible, 3D MHD simulation of AR corona formation following magnetic flux emergence. We then present results from the application of the method to AIA observations of Active Region 11158, comparing the region's thermal structure on two successive solar rotations. Additionally, we show how the DEM inversion method can be adapted to simultaneously invert AIA and XRT data, and how supplementing AIA data with the latter improves the inversion result. The speed of the method allows for routine production of DEM maps, thus facilitating science studies that require tracking of the thermal structure of the solar corona in time and space.
description: 21 pages, 18 figures, accepted for publication in ApJ
(101302) Richard Born
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Abdominal Wall Hernias: beyond the common
Creators: name: Ventosa, Ana Rita
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Hernia
subject: Education
subject: MR
subject: CT
subject: Conventional radiography
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To perceive the wide range of imaging findings associated with abdominal wall hernias, focusing in uncommon features. To classify unusual abdominal wall hernias according to their specific...
Geometric Phases for Mixed States of the Kitaev Chain
Creators: name: Andersson, Ole
name: Bengtsson, Ingemar
name: Ericsson, Marie
name: Sjöqvist, Erik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The Berry phase has found applications in building topological order parameters for certain condensed matter systems. The question whether some geometric phase for mixed states can serve the same purpose has been raised, and proposals are on the table. We analyze the intricate behaviour of Uhlmann's geometric phase in the Kitaev chain at finite temperature, and then argue that it captures quite different physics from that intended. We also analyze the behaviour of a geometric phase introduced in the context of interferometry. For the Kitaev chain, this phase closely mirrors that of the Berry phase, and we argue that it merits further investigation.
description: Minor corrections; journal reference added
title: Lost Art of Clinical examination: audit of requests of Chest Radiographs
Creators: name: khosa, huma
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Emergency
subject: Management
subject: Thorax
subject: Conventional radiography
subject: Digital radiography
subject: Audit and standards
subject: Decision analysis
subject: Acute
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: We present an audit of chest radiographs requests from the Emergency Department, analysing the clinical information and examination details...
title: Amiodarone Pulmonary Toxicity: Pictorial Review of the Main Radiological Manifestations
Creators: name: Oliveira, Eduardo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Drugs / Reactions
subject: Education
subject: Digital radiography
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Lung

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1) Provide an overview of amiodarone use and the prevalence and clinical relevance of amiodarone-induced toxicity. 2) Review the mechanisms and pathogenesis of amiodarone toxicity. 3)Illustrate and discuss the radiological manifestations of...
Theory of long-range ultracold atom-molecule photoassociation
Creators: name: Pérez-Ríos, Jesús
name: Lepers, Maxence
name: Dulieu, Olivier
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The creation of ultracold molecules is currently limited to diatomic species. In this letter we present a theoretical description of the photoassociation of ultracold atoms and molecules to create ultracold excited triatomic molecules, thus being a novel example of light-assisted ultracold chemical reaction. The calculation of the photoassociation rate of ultracold Cs atoms with ultracold Cs$_2$ molecules in their rovibrational ground state is reported, based on the solution of the quantum dynamics involving the atom-molecule long-range interactions, and assuming a model potential for the short-range physics. The rate for the formation of excited Cs$_3$ molecules is predicted to be comparable with currently observed atom-atom photoassociation rates. We formulate an experimental proposal to observe this process relying on the available techniques of optical lattices and standard photoassociation spectroscopy.
description: 5 pages, 3 figures