cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
State-Transfer Simulation in Integrated Waveguide Circuits
Creators: name: Latmiral, Ludovico
name: Di Franco, Carlo
name: Mennea, Paolo L.
name: Kim, Myungshik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Spin-chain models have been widely studied in terms of quantum information processes, for instance for the faithful transmission of quantum states. Here, we investigate the limitations of mapping this process to an equivalent one through a bosonic chain. In particular, we keep in mind experimental implementations, which the progress in integrated waveguide circuits could make possible in the very near future. We consider the feasibility of exploiting the higher dimensionality of the Hilbert space of the chain elements for the transmission of a larger amount of information, and the effects of unwanted excitations during the process. Finally, we exploit the information-flux method to provide bounds to the transfer fidelity.
description: 8 pages, 6 figures, RevTeX4
SI Tables; Reduced matrix; Figure of rates including Xenarthra branch; Topological constraint from Rapid morphological evolution in placental mammals post-dates the origin of the crown group
Creators: name: Halliday, Thomas J. D.
name: Reis, Mario Dos
name: Tamuri, Asif U.
name: Ferguson-Gow, Henry
name: Ziheng Yang
name: Goswami, Anjali
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60408 Genomics

description: Tables containing the raw values depicted in Figure 1; An exemplar matrix of morphological and molecular data with which a basic version of the results can be replicated; Morphological:molecular rates like that of Figure 2A but including the aberrant xenarthran ratios.; Constraint file for RAxML analysis
Programme costs of longer and shorter tuberculosis drug regimens and drug import: a modelling study for Karakalpakstan, Uzbekistan
Creators: name: Kohler, Stefan
name: Sitali, Norman
name: Achar, Jay
name: Paul, Nicolas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: tuberculosis drug regimens
subject: Karakalpakstan
subject: TB programmes
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The introduction of new and often shorter tuberculosis (TB) drug regimens affects the cost of TB programmes. Methods: We modelled drug purchase and import costs for 20-month, 9-month and 4- to 6-month TB drug regimens based on 2016–2020 treatment numbers from a TB programme in Karakalpakstan, Uzbekistan, and 2021 Global Drug Facility prices. Results: On average, 2225±374 (±sd) people per year started TB treatment, 30±2.1% of whom were diagnosed with drug-resistant forms of TB. Transitioning from a 6-month to a 4-month drug-susceptible (DS)-TB drug regimen increased the TB programme's annual DS-TB drug cost from USD 65±10 K to USD 357±56 K (p<0.001) and its drug import cost from USD 6.4±1.0 K to USD 9.3±1.4 K (p=0.008). Transitioning from a 20-month all-oral multidrug-resistant (MDR)-TB drug regimen to a 9-month MDR-TB drug regimen with an injectable antibiotic decreased the TB programme's annual MDR-TB drug cost from USD 1336±265 K to USD 266±53 K (p<0.001) and had no significant effect on the drug import cost (USD 28±5.5 K versus USD 27±5.4 K; p=0.88). Purchasing (USD 577±114 K) and importing (USD 3.0±0.59 K) the 6-month all-oral MDR-TB drug regimen cost more than procuring the 9-month MDR-TB drug regimen but less than the 20-month all-oral MDR-TB drug regimen (both p<0.01). Conclusion: Introducing new and shorter TB drug regimens could increase the cost of TB programmes with low drug resistance rates and decrease the cost of TB programmes with high drug resistance rates.
Genes used for molecular alignment from Rapid morphological evolution in placental mammals post-dates the origin of the crown group
Creators: name: Halliday, Thomas J. D.
name: Reis, Mario Dos
name: Tamuri, Asif U.
name: Ferguson-Gow, Henry
name: Ziheng Yang
name: Goswami, Anjali
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60408 Genomics

description: Details of all genomic data used in this analysis
(1441) William Porritt Ingham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani
Creators: name: Hassan, Ahmed H. E.
name: Bayoumi, Waleed A.
name: El-Sayed, Selwan M.
name: Phan, Trong-Nhat
name: Kim, Yeon Ju
name: Lee, Chae Hyeon
name: Bin Cho, Soo
name: Oh, Taegeun
name: Ham, Gyeongpyo
name: Mahmoud, Kazem
name: No, Joo Hwan
name: Lee, Yong Sup
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids 7c, 7n, and 7h showed potential IC50 values (9.8, 10, and 12 µM, respectively) which were comparable to erufosine IC50 (9.8 µM) but lower potency than miltefosine IC50 (3.5 µM). Preliminary assessment of cytotoxicity using human THP-1 cells presented chromone-peptidyl hybrids 7c and 7n as non-cytotoxic up to 100 µM while erufosine and miltefosine had CC50 of 19.4 µM and >40 µM, respectively. In silico studies pinpointed the N-p-methoxyphenethyl substituent at the peptidyl moiety together with the oxygen-based substituted functions of the phenyl ring of the chromone moiety as crucial players in binding to LdCALP. Together, these findings present chromone-peptidyl hybrids 7c and 7n as potential and anticipated non-cytotoxic antileishmanial hit compounds for possible development of potential antileishmanial agents against visceral leishmaniasis.
Supplementary_Material_Appendix_A1 from Magnetic storms disrupt nocturnal migratory activity in songbirds.
Creators: name: Bianco, Giuseppe
name: Ilieva, Mihaela
name: Åkesson, Susanne
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Raw data in graphical format.
Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency
Creators: name: Fruchart, Jamila
name: Maeda, Nobuyo
name: Castro, Graciela
name: Torpier, Gerard
name: Rouis, Mustapha
name: Larigauderie, Guilhem
name: Fruchart, Jean Charles
name: Nowak, Maxime
name: Mezdour, Hafid
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster
Living with Chronic Pain During the COVID-19 Pandemic: A Qualitative Analysis
Creators: name: Balestra, Anna Marie
name: Chalk, Katharina
name: Spies, Claudia
name: Denke, Claudia
name: Krampe, Henning
name: Tafelski, Sascha
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: COVID-19 pandemic
subject: telemedicine
subject: mental distress
subject: coping
subject: chronic pain
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: COVID-19 pandemic containment measures have led to changes in various areas of life, including restrictions on health care. Patients with chronic pain may have faced an increased burden during pandemic and the resources of this vulnerable population are unknown. Therefore, a qualitative study was conducted to understand how people with chronic pain have experienced the course of the pandemic. Patients and Methods: Twenty semi-structured telephone interviews were conducted six months after the initial lockdown in Germany. The participants were patients with chronic pain who exhibited varying changes in their pain during the first German lockdown, recruited from a German outpatient pain clinic at a Department of Anesthesiology and Intensive Care. The semi-structured interview guidelines were designed to explore how patients with chronic pain experienced their pain during the pandemic, how they coped, and how they experienced pain management during this time. The interview recordings were transcribed verbatim and coded using the qualitative content analysis method. Results: Four themes emerged from the results: differential impact on pain experience, difficulty coping with pain, supportive pain management, and endurance. Conclusion: During this uncertain time, it was particularly important to maintain pain treatment in order to establish a sense of safety and stability. This underscores the special role of maintaining therapeutic contact during a pandemic and the potentially special role of telemedicine.
Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study
Creators: name: Laston, S.
name: Almasy, L.
name: Fabsitz, R. R.
name: Göring, H. H.H.
name: Diego, V. P.
name: Lee, E. T.
name: Best, L. G.
name: Cantu, T.
name: MacCluer, J. W.
name: Cole, S. A.
name: North, K. E.
name: Howard, B. V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Previous studies have demonstrated that low density lipoprotein cholesterol (LDL-C) concentration is influenced by both genes and environment. Although rare genetic variants associated with Mendelian causes of increased LDL-C are known, only one common genetic variant has been identified, the apolipoprotein E gene (
(1442) Florence [Ingham]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Double-nucleus elliptical MCG-01-12-005 in an X-ray emitting cluster of galaxies
Creators: name: Nesci, Roberto
name: Fiocchi, Mariateresa
name: Bassani, Loredana
name: Parisi, Pietro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The scenario of galaxy formation is believed to follow a structure that builds up from the bottom, with large galaxies being formed by several merging episodes of smaller ones. In this scenario a number of galaxies can be expected to be seen in the merging phase, with their external regions already mixed, while their nuclei, with stronger self-gravitation, are still recognizable as such. During a photometric monitoring of AGNs in the field of a long-exposure INTEGRAL pointing, we serendipitously found an elliptical galaxy in the center of the X-ray cluster (EXO 0422-086) with two nuclei. We performed surface photometry on our images and those of the SDSS archive and obtained slit spectra of both nuclei. Aperture photometry of the two stellar-like nuclei showed very similar colors in the SDSS image and in our Johnson BVRI images, which is typical of an elliptical galaxy nucleus. The spectra of the nuclei showed the typical absorption lines of an elliptical galaxy without appreciable emission lines. The redshifts derived from each nucleus were equal and fully consistent with the literature value (0.0397). We can therefore exclude the possibility that one of the nuclei is a foreground star or a background AGN and consider this elliptical galaxy as a bona fide example of a galaxy merger.
description: 4 pages, 3 figures. Accepted on Astronomy and Astrophysics
Supplementary_Material_Figure_S2 from Magnetic storms disrupt nocturnal migratory activity in songbirds.
Creators: name: Bianco, Giuseppe
name: Ilieva, Mihaela
name: Åkesson, Susanne
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Actogram for three species of first-year migratory songbirds video-recorded during their migratory period. Each horizontal line shows the mean time spent in flying mode by 24 birds (n=8 for each species) during 24h period (from 12:00 to 12:00 of the following day) in 20-min intervals. Birds were considered active if spending more than 1% of the 20-min time interval in flying mode. White vertical lines delineate selected time periods used in the analysis (Evening, Night and Morning).
Risk factors for malignant transformation of hepatocellular adenoma to hepatocellular carcinoma: protocol for systematic review and meta-analysis
Creators: name: Thevathasan, Tharusan
name: Colbatzky, Teresa
name: Schmelzle, Moritz
name: Pratschke, Johann
name: Krenzien, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: hepatology
subject: hepatobiliary tumours
subject: hepatobiliary disease
subject: hepatobiliary surgery
subject: risk management
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Hepatocellular adenomas (HCAs) are solid liver tumours that are usually found incidentally during routine medical check-ups. Multiple modifiable and non-modifiable factors constitute a risk for the malignant transformation of HCAs to hepatocellular carcinoma (HCC), which has emerged to be one of the fastest growing causes of cancer-related mortality globally. This study protocol for a planned systematic review and meta-analysis documents the methodological approach to identify risk factors and their risk estimates for the transformation from HCA to HCC. Methods and analysis: Two independent reviewers will systematically search and extract data from studies in patients of all ages published between January 1970 and June 2021 on PubMed, MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Scopus Web of Science, Ovid, The Cochrane Hepatobiliary Group Controlled Trials Register and The Cochrane Central Register of Controlled Trials by using an a priori defined search strategy. Study quality will be rated with the National Institute of Health quality assessment tools. Disagreements will be resolved by consensus with a third independent reviewer. The primary outcome will be the odds ratio (OR) of developing HCC in patients with prediagnosed HCA depending on the exposure to risk factors. HCC diagnosis must be inferred based on imaging techniques or pathology. We will use R V.4.0.2 to conduct meta-analyses and generate pooled ORs based on random effects models. Results will be presented as forest plots. Cochran’s Q and I2 test will be performed to assess heterogeneity between included studies. Funnel plots and Egger’s weighted regression will be used to evaluate publication bias. Ethics and dissemination: No ethical approval is required as we will use and analyse data from previously published studies in which informed consent was obtained. The results will be disseminated in a peer-reviewed journal on completion. PROSPERO registration number: CRD42020206578.
(1443) William Ingham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamical de Sitter phase and nontrivial holonomy in strongly coupled gauge theories in expanding Universe
Creators: name: Zhitnitsky, Ariel R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss a new scenario for early cosmology when the inflationary de Sitter phase emerges dynamically. This genuine quantum effect occurs as a result of dynamics of the topologically nontrivial sectors in a strongly coupled QCD- like gauge theory in an expanding universe. We test these ideas by explicit computations in hyperbolic space $ \mathbb{H}^3_κ\times \mathbb{S}^1_{κ^{-1}}$. We argue that the key element for this idea to work is the presence of nontrivial holonomy computed along $\mathbb{S}^1_{κ^{-1}}$. The effect is non-local in nature, non-analytical in coupling constant and can not be described in terms of any local propagating degree of freedom such as scalar inflaton field $Φ(x)$. We discuss some profound phenomenological consequences of this scenario for inflationary cosmology. We also suggest to test these ideas in a tabletop experiment by measuring some specific corrections to the Casimir pressure in the Maxwell theory formulated on a topologically nontrivial manifold.
description: matches the published version
НАПИТОК С АНТИОКСИДАНТНЫМИ СВОЙСТВАМИ НА ОСНОВЕ CLITORIA TERNATEA, ГИБИСКУСА И ЛИЧИ
Creators: name: ЕРМОЛАЕВА ГАЛИНА АЛЕКСЕЕВНА
name: ШАГИЕВ МИХАИЛ ЮРЬЕВИЧ
Publisher: name: Пиво и напитки
Year: 2020
Subjects: АНЧАН
ГИБИСКУС
ЛИЧИ
НАПИТОК
ПОЛИФЕНОЛЫ
ТЕРНАТИНЫ
АНТИОКСИДАНТНЫЕ СВОЙСТВА
АNCHAN
HIBISCUS
LYCHEE
DRINK
POLYPHENOLS
TERNATINS
ANTIOXIDANT PROPERTIES

description: По результатам изучения научно-технической литературы в качестве сырья для напитков, обладающих антиоксидантными свойствами, были выбраны цветы анчана (Clitoria ternatea), гибискуса и сок из плодов личи. Цветы анчана и гибискуса содержат фенольные соединения, поэтому, предположительно, обладают антиоксидантными свойствами. У анчана, по литературным данным, высокое содержание антоциановых соединений - тернатинов - обладающих устойчивой сине-лиловой окраской, что представляет интерес для приготовления напитка со стабильными свойствами. У каждого из выбранных видов сырья богатый витаминный и элементный состав. В работе изучены показатели сырья и напитков: содержание сухих и полифенольных веществ, антиоксидантная активность (АОА), кислотность. Установлено, что данные по АОА и содержанию полифенолов в образцах анчана, гибискуса и сока личи свидетельствуют об их достаточно высоком потенциале при использовании в напитках. Наибольшую АОА показал сок личи, чуть меньшую - гибискус. Наиболее высоким содержанием полифенолов обладает гибискус. Прямого соотношения содержания полифенольных веществ и АОА не отмечено. Выбранные из четырех два образца напитка с разным содержанием сока имели сбалансированные органолептические показатели и рекомендованы для рациона человека как напитки, обладающие АОА.
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet
Creators: name: Coleman, Rosalind A.
name: Mashek, Douglas G.
name: Li, Lei O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeeding a 69% sucrose diet. Not only did quantitative real-time PCR analyses reveal unique tissue expression patterns for each ACSL isoform, but expression varied markedly in different adipose depots. Fasting increased ACSL4 mRNA abundance in liver, muscle, and gonadal and inguinal adipose tissues, and refeeding decreased ACSL4 mRNA. A similar pattern was observed for ACSL1, but both fasting and refeeding decreased ACSL1 mRNA in gonadal adipose. Fasting also decreased ACSL3 and ACSL5 mRNAs in liver and ACSL6 mRNA in muscle. Surprisingly, in nearly every tissue measured, the effects of fasting and refeeding on the mRNA abundance of ACSL1 and ACSL4 were discordant with changes in protein abundance. These data suggest that the individual ACSL isoforms are distinctly regulated across tissues and show that mRNA expression may not provide useful information about isoform function. They further suggest that translational or posttranslational modifications are likely to contribute to the regulation of ACSL isoforms.
Associative production of $Υ$ and open charm at LHC
Creators: name: Berezhnoy, A. V.
name: Likhoded, A. K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The yield of $Υ$ associated with open charm has been estimated with different approaches. The crucial differences between SPS and DPS predictions are discussed.
description: 6 pages, 5 figures
Supplementary_Material_Figure_S1 from Magnetic storms disrupt nocturnal migratory activity in songbirds.
Creators: name: Bianco, Giuseppe
name: Ilieva, Mihaela
name: Åkesson, Susanne
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Example of geomagnetic intensity profile during a magnetic storm recorded between 7 and 8 October 2015 in the same facility and with the same equipment used during the experiments. The red circle indicates a phase of short-term periodic variation of the disturbance that we tried to replicate in amplitude and frequency composition during our experiment.
Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?
Creators: name: Voltolini Velho, Renata
name: Taube, Eliane
name: Sehouli, Jalid
name: Mechsner, Sylvia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: endometriosis
subject: neurogenic inflammation
subject: neuroimmune modulation
subject: nerve signalling
subject: peripheral nerve
subject: inflammation
subject: non-hormonal treatment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although EM was first described in 1860, its aetiology and pathogenesis remain uncertain. Recent evidence demonstrates that the peripheral nervous system plays an important role in the pathophysiology of this disease. Sensory nerves, which surround and innervate endometriotic lesions, not only drive the chronic and debilitating pain associated with EM but also contribute to a growth phenotype by secreting neurotrophic factors and interacting with surrounding immune cells. Here we review the role that peripheral nerves play in driving and maintaining endometriotic lesions. A better understanding of the role of this system, as well as its interactions with immune cells, will unearth novel disease-relevant pathways and targets, providing new therapeutics and better-tailored treatment options.
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms
Creators: name: Sequeira, Lisa
name: Distinto, Simona
name: Meleddu, Rita
name: Gaspari, Marco
name: Angeli, Andrea
name: Cottiglia, Filippo
name: Secci, Daniela
name: Onali, Alessia
name: Sanna, Erica
name: Borges, Fernanda
name: Uriarte, Eugenio
name: Alcaro, Stefano
name: Supuran, Claudiu T.
name: Maccioni, Elias
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering the high pharmacological potential of the chromene scaffold as selective ligand of the IX and XII isoforms, two libraries of compounds, namely 2H-chromene and 7H-furo-chromene derivatives, with diverse substitution patterns were designed and synthesised. The structure of the newly synthesised compounds was characterised and their inhibitory potency and selectivity towards human CA off target isoforms I, II and cancer-associated CA isoforms IX and XII were evaluated. Most of the compounds inhibit CA isoforms IX and XII with no activity against the I and II isozymes. Thus, while the potency was influenced by the substitution pattern along the chromene scaffold, the selectivity was conserved along the series, confirming the high potential of both 2H-chromene and 7H-furo-chromene scaffolds for the design of isozyme selective inhibitors.
On the disformal invariance of the Dirac equation
Creators: name: Bittencourt, Eduardo
name: Lobo, Iarley P.
name: Carvalho, Gabriel G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we analyze the invariance of the Dirac equation under disformal transformations depending on the propagating spinor field. Using the Weyl-Cartan formalism, we construct a large class of disformal maps between different metric tensors, respecting the order of differentiability of the Dirac operator and satisfying the Clifford algebra in both metrics. Then, we have shown that there is a subclass of solutions of the Dirac equation, provided by Inomata's condition, which keeps the Dirac operator invariant under the action of the disformal group.
description: 12 pages; This matches the version to be published in CQG
СРАВНИТЕЛЬНАЯ ОЦЕНКА СПОСОБОВ СБРАЖИВАНИЯ КИЗИЛА ПРИ ПРОИЗВОДСТВЕ ДИСТИЛЛЯТОВ
Creators: name: ДУБИНИНА ЕЛЕНА ВАСИЛЬЕВНА
name: КРИКУНОВА ЛЮДМИЛА НИКОЛАЕВНА
name: ТРОФИМЧЕНКО ВЛАДИМИР АЛЕКСАНДРОВИЧ
name: ТОМГОРОВА СВЕТЛАНА МИХАЙЛОВНА
Publisher: name: Пиво и напитки
Year: 2020
Subjects: ИЗМЕНЕНИЕ ФИЗИКО-ХИМИЧЕСКОГО СОСТАВА
ЛЕТУЧИЕ КОМПОНЕНТЫ
ПЛОДЫ КИЗИЛА
СПОСОБ СБРАЖИВАНИЯ
CHANGE IN PHYSICAL AND CHEMICAL COMPOSITION
VOLATILE COMPONENTS
CORNEL FRUITS
FERMENTATION METHOD

description: В последнее время широкую популярность набирают напитки на основе фруктовых (плодовых) дистиллятов. Исследование биохимического состава плодов кизила показало необходимость разработки режимных параметров подготовки данного вида сырья к дистилляции. Цель настоящей работы состояла в определении оптимального способа сбраживания плодов кизила. В качестве объектов исследования были изучены 3 образца сброженного сырья, полученных разными способами: брожение неосветленного сока (Образец 1); подбраживание мезги без косточек и его дображивание (Образец 2); сбраживание мезги без отделения сока (Образец 3). Для проведения процесса использовали сухие дрожжи Saccharomyces cerevisiae расы «Red Fruit». Образец 3 обладал более высокой бродильной активностью, с наибольшим набродом спирта при минимальной концентрации сахаров в сусле. Наблюдалось понижение концентрации летучих кислот в 1,5 раза по сравнению с Образцом 2 и увеличение концентрации титруемых кислот. В зависимости от выбора способа сбраживания менялись концентрации отдельных органических кислот, таких как винная, молочная, лимонная и янтарная. Образец 3 содержал этилацетат и небольшие концентрации энантового эфира и более высокую концентрацию фенилэтилового спирта. Использование для сбраживания сока кизила способствовало увеличению метанола в 1,5-2,0 раза. В целом результаты проведенных исследований показали преимущество сбраживания мезги, позволяя сократить продолжительность процесса в 2 раза, повысить наброд этанола в среднем на 1,4%, снизить концентрацию метанола и высших спиртов, а также накопить ценные ароматобразующие летучие компоненты.
Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
Creators: name: Altenburg, Michael K.
name: De, Sheng Gu
name: Maeda, Nobuyo
name: Mazzone, Theodore
name: Lucic, Danijela
name: Zhi, Hua Huang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net secretion of apoE from macrophages. In these studies, we demonstrate that treatment of J774 macrophages transfected to constitutively express a human apoE3 cDNA with simvastatin, to increase LDL receptor activity, reduces the secretion of apoE. To further examine the relationship between LDL receptor expression and apoE secretion from macrophages, mouse peritoneal macrophages (MPMs) were isolated from mice with constitutively high expression of human LDL receptor to increase overall LDL receptor expression by 2- to 3-fold. Cells with increased LDL receptor expression also showed reduced apoE secretion compared with MPMs with basal LDL receptor expression. The effect of changes in LDL receptor expression on apoE secretion was isoform-specific, with greater reduction of apoE4 compared with apoE3 secretion and no reduction of apoE2 secretion, paralleling the known affinity of each isoform for LDL receptor binding. The effect of the LDL receptor on apoE secretion for each isoform was further reflected in LDL receptor-dependent changes in apoE-mediated cholesterol efflux. These results establish a regulatory interaction between two branches of macrophage sterol homeostatic pathways that could facilitate a rapid r
Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations
Creators: name: Haffez, Hesham
name: Elsayed, Nosaiba A.
name: Ahmed, Marwa F.
name: Fatahala, Samar S.
name: Khaleel, Eman F.
name: Badi, Rehab Mustafa
name: Elkaeed, Eslam B.
name: Hassab, Mahmoud A. El
name: Hammad, Sherif F.
name: Eldehna, Wagdy M.
name: Masurier, Nicolas
name: El-Haggar, Radwan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Significant advancements have been made in the domain of targeted anticancer therapy for the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal involvement in angiogenesis and subsequent mechanisms that promote tumour cells survival. Herein, novel N-arylmethyl-aniline/chalcone hybrids 5a–5n were designed and synthesised as potential anticancer and VEGFR-2 inhibitors. The anticancer activity was evaluated at the NCI-USA, resulting in the identification of 10 remarkably potent molecules 5a–5j that were further subjected to the five-dose assays. Thereafter, they were explored for their VEGFR-2 inhibitory activity where 5e and 5h emerged as the most potent inhibitors. 5e and 5h induced apoptosis with cell cycle arrest at the SubG0-G1 phase within HCT-116 cells. Moreover, their impact on some key apoptotic genes was assessed, suggesting caspase-dependent apoptosis. Furthermore, molecular docking and molecular dynamics simulations were conducted to explore the binding modes and stability of the protein–ligand complexes.
Enhancement of the CP-odd effect in the nuclear electric dipole moment of $^6$Li
Creators: name: Yamanaka, Nodoka
name: Hiyama, Emiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We calculate for the first time the electric dipole moment (EDM) of the $^6$Li nucleus within the alpha + p + n three-body cluster model using the Gaussian expansion method, assuming the one meson exchange P, CP-odd nuclear forces. It is found that the EDM of the $^6$Li is 2 times more sensitive on the isovector pion exchange P, CP-odd nuclear force than the deuteron EDM, due to the CP-odd interaction between the nucleons and the alpha cluster. The $^9$Be EDM is also calculated in the same framework as an alpha + alpha + n three-body system. We also test the ab initio calculation of the EDM of the deuteron, $^3$H and $^3$He nuclei using the realistic Argonne $v18$ nuclear force. In the ab initio calculations, good agreements with previous studies are obtained. We finally discuss the prospects for the new physics beyond the standard model.
description: 6 pages, 1 figure
(1436) Eleanor Seaton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Deep Infiltrating Endometriosis and Adenomyosis: Implications on Pregnancy and Outcome
Creators: name: Gruber, Teresa Mira
name: Ortlieb, Laura
name: Henrich, Wolfgang
name: Mechsner, Sylvia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: deep infiltrating endometriosis
subject: adenomyosis
subject: archimetrosis
subject: pregnancy outcome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Endometriosis (EM), especially deep infiltrating endometriosis (DIE) and adenomyosis (AM), are known to cause pain and sterility in young women. More recently, they have also been described as risk factors for obstetric complications. While the pathophysiology is not yet completely understood, they seem to share a common origin: archimetrosis. Methods: A systematic literature review was conducted to summarize the existing evidence on DIE and AM as risk factors for obstetric complications. Results: Preterm birth, caesarean section delivery (CS) and placental abnormalities are associated with the diagnosis of DIE and AM. Women with AM seem to experience more often hypertensive pregnancy disorders, premature rupture of membranes and their children are born with lower birth weights than in the control groups. However, many of the studies tried to evaluate AM, EM and DIE as separate risk factors. Moreover, often they did not adjust for important confounders such as multiple pregnancies, parity, mode of conception and maternal age. Therefore, prospective studies with larger numbers of cases and appropriate adjustment for confounders are needed to explore the pathophysiology and to prove causality.
SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes
Creators: name: McIntosh, Avery L.
name: Schroeder, Friedhelm
name: Gallegos, Adalberto M.
name: Atshaves, Barbara P.
name: Kier, Ann B.
name: Maeda, Nobuyo
name: Landrock, Kerstin
name: Payne, H. Ross
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Although reverse cholesterol transport from peripheral cell types is mediated through plasma membrane microdomains termed lipid rafts, almost nothing is known regarding the existence, protein/lipid composition, or structure of these putative domains in liver hepatocytes, cells responsible for the net removal of cholesterol from the body. Lipid rafts purified from hepatocyte plasma membranes by a nondetergent affinity chromatography method were:
Between Freedom and Formalisation: a Hypergraph Model for Representing the Nature of Text
Creators: name: Bleeker, Elli
name: Buitendijk, Bram
name: Haentjens Dekker, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: text modeling
text as graph
text encoding
non-linearity
discontinuity
textual genetic editing

description: Text-as-Graph (TAG) is a hypergraph model for text developed and maintained by the R&D group of the KNAW Humanities Cluster. In this long-paper, we present the theoretical and practical implications of using the TAG data model and the associated syntax TAGML to express textual features (such as nonlinear and discontinuous text) in a way that corresponds more closely with the scholar’s understanding of it. We will give examples from the field of textual genesis studies, which presents some particularly intriguing requirements for text modeling, such as overlapping, non-linear, or discontinuous text structures. As TAG considers text as a network of often implicit information, TAGML documents are inherently multi-layered and non-linear, and combine ordered and unordered information. Accordingly, scholars can digitally represent their understanding of a text in a more explicit and formalised manner. This paves the way to an innovative approach to creating, modeling, and processing textual objects.
Supplementary_Material_Appendix_A1 from Magnetic storms disrupt nocturnal migratory activity in songbirds
Creators: name: Bianco, Giuseppe
name: Ilieva, Mihaela
name: Åkesson, Susanne
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Raw data in graphical format.
Stability of toroidal magnetic fields in stellar interiors
Creators: name: Ibañez-Mejia, Juan C.
name: Braithwaite, Jonathan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present 3D MHD simulations of purely toroidal and mixed poloidal-toroidal magnetic field configurations to study the behavior of the Tayler instability. For the first time the simultaneous action of rotation and magnetic diffusion are taken into account and the effects of a poloidal field on the dynamic evolution of unstable toroidal magnetic fields is included. In the absence of diffusion, fast rotation (rotation rate compared to Alfvén frequency) is able to suppress the instability when the rotation and magnetic axes are aligned and when the radial field strength gradient p < 1.5. When diffusion is included, this system turns unstable for diffusion dominated and marginally diffusive dominated regions. If the magnetic and rotation axes are perpendicular to each other the stabilizing effect induced by the Coriolis force is scale dependent and decreases with increasing wavenumber. In toroidal fields with radial field gradients bigger than p > 1.5, rapid rotation does not suppress the instability but instead introduces a damping factor to the growth rate in agreement with the analytic predictions. For the mixed poloidal-toroidal fields we find an unstable axisymmetric mode, not predicted analytically, right at the stability threshold for the non-axisymmetric modes; it has been argued that an axisymmetric mode is necessary for the closure of the Tayler-Spruit dynamo loop.
description: 12 pages, 12 figures. Accepted for publication in A&A
The pathologies associated with functional titration of phosphatidylinositol transfer protein α activity in mice
Creators: name: Bankaitis, Vytas A.
name: Phillips, Scott E.
name: Philpot, Benjamin D.
name: Alb Jr., James G.
name: Wilfley, Lindsey R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Phosphatidylinositol transfer proteins (PITPs) bind phosphatidylinositol (PtdIns) and phosphatidylcholine and play diverse roles in coordinating lipid metabolism/signaling with intracellular functions. The underlying mechanisms remain unclear. Genetic ablation of PITPalpha in mice results in neonatal lethality characterized by intestinal and hepatic steatosis, spinocerebellar neurodegeneration, and glucose homeostatic defects. We report that mice expressing a PITPalpha selectively ablated for PtdIns binding activity (Pitpalpha(T59D)), as the sole source of PITPalpha, exhibit phenotypes that recapitulate those of authentic PITPalpha nullizygotes. Analyses of mice with graded reductions in PITPalpha activity reveal proportionately graded reductions in lifespan, demonstrate that intestinal steatosis and hypoglycemia are apparent only when PITPalpha protein levels are strongly reduced (>or=90%), and correlate steatotic and glucose homeostatic defects with cerebellar inflammatory disease. Finally, reconstitution of PITPalpha expression in the small intestine substantially corrects the chylomicron retention disease and cerebellar inflammation of Pitpalpha(0/0) neonates, but does not rescue neonatal lethality in these animals. These data demonstrate that PtdIns binding is an essential functional property of PITPalpha in vivo, and suggest a causal linkage between defects in lipid transport and glucose homeostasis and cerebellar inflammatory disease. Finally, the data also demonstrate intrinsic neuronal deficits in PITPalpha-deficient mice that are independent of intestinal lipid transport defects and hypoglycemia.
НАПРАВЛЕНИЕ СОВЕРШЕНСТВОВАНИЯ ТЕХНОЛОГИЙ ДИСТИЛЛЯТА ИЗ ВОЗВРАТНЫХ ОТХОДОВ ХЛЕБОПЕКАРНОГО ПРОИЗВОДСТВА
Creators: name: КРИКУНОВА ЛЮДМИЛА НИКОЛАЕВНА
name: ЗАХАРОВ МАКСИМ АЛЕКСАНДРОВИЧ
name: ОБОДЕЕВА ОЛЬГА НИКОЛАЕВНА
Publisher: name: Пиво и напитки
Year: 2020
Subjects: БЕЛКИ
ВОЗВРАТНЫЕ ОТХОДЫ ХЛЕБОПЕКАРНОГО ПРОИЗВОДСТВА
ЗЕРНОВЫЕ ОТРУБИ
СВОБОДНЫЕ АМИНОКИСЛОТЫ
PROTEIN
BAKERY RETURNABLE WASTE
CEREAL BRAN
FREE AMINO ACIDS

description: Возвратные отходы хлебопекарного производства - это нетрадиционное сырье для производства дистиллятов. Углеводный комплекс данного вида сырья характеризуется повышенным по сравнению с зерном содержанием сбраживаемых углеводов, в первую очередь крахмалом, декстринами, олиго-, ди- и моносахаридами. Выявленные отличия позволили позитивно оценить новый вид сырья, так как он имел преимущества по выходу дистиллята из единицы сырья. Вместе с тем возвратные отходы хлебопекарного производства отличались пониженным содержанием как общих белков, так и растворимых форм. Поэтому в разработанной технологии дистиллятов из данного вида сырья были использованы ферментные препараты протеолитического действия (с повышенной нормой дозировки), а также активаторы брожения с высоким содержанием аминокислот. В качестве альтернативы, предложен вариант с использованием зерновых отрубей, отличающихся высоким содержанием азотосодержащих компонентов. Объектами исследования были выбраны пшеничные отруби, полученные с предприятий Москвы и Московской обл. Оценка белкового комплекса отрубей включала определение общего содержания белка, растворимого белка, аминного азота и концентрацию свободных аминокислот. Установлено, что содержание общего белка практически не зависит от гранулометрического состава отрубей напротив выявлено, что максимальным содержанием растворимого белка и аминного азота отличаются отруби мелкого помола. Содержание свободных аминокислот, в пшеничных отрубях превышает их содержание в отходах хлебопекарного производства (хлеб пшеничный) в среднем в 10-15 раз. Содержание таких важных для технологии дистиллятов аминокислот как треонин, валин, лейцин и изолейцин в пшеничных отрубях, по сравнению с отходами хлебопекарного производства, возрастает соответственно в 16-22 раза, в 5-6 раз, 15-23 раза, в 4-8 раз. Выявлено влияние гранулометрического состава отрубей как на суммарное содержание аминокислот, так и на количество отдельных аминокислот. Кроме того, выявлена четкая зависимость увеличения суммарного содержания свободных аминокислот в ряду крупные отруби → средние отруби → мелкие отруби. В целом, анализ белкового комплекса пшеничных отрубей показал, что по сравнению с отходами хлебопекарного производства, полученными из пшеничной муки, они характеризуются повышенным содержанием общего белка в среднем на 1,2-2,9%, увеличенной массовой долей растворимого белка в 3,7-7,9 раз, аминного азота в 10,0-18,6 раз, суммарным содержанием свободных аминокислот в 10,4-15,7 раз.
Purification and characterisation of glutathione reductase from scorpionfish (scorpaena porcus) and investigation of heavy metal ions inhibition
Creators: name: Işık, Kübra
name: Soydan, Ercan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified

description: In the current study, glutathione reductase was purified from Scorpion fish (Scorpaena porcus) liver tissue and the effects of heavy metal ions on the enzyme activity were determined. The purification process consisted of three stages; preparation of the homogenate, ammonium sulphate precipitation and affinity chromatography purification. At the end of these steps, the enzyme was purified 25.9-fold with a specific activity of 10.479 EU/mg and a yield of 28.3%. The optimum pH was found to be 6.5, optimum substrate concentration was 2 mM NADPH and optimum buffer was 300 mM KH2PO4. After purification, inhibition effects of Mn+2, Cd+2, Ni+2, and Cr3+, as heavy metal ions were investigated. IC50 values of the heavy metals were calculated as 2.4 µM, 30 µM, 135 µM and 206 µM, respectively.
КАК ОБУЧИТЬ МОДЕЛЬ МАШИННОГО ОБУЧЕНИЯ?
Creators: name: Адилова, Муножот
Publisher: name: Zenodo
Year: 2023

description: Данная тема рассматривает основные этапы и методы обучения моделей машинного обучения. Машинное обучение — это процесс, при котором модель обучается на основе предоставленных данных, в целях выполнения определённых задач.