cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mask-based enhancement of very noisy speech
Creators: name: Lightburn, Leo Charles
Publisher: name: Imperial College London
Year: 2019

description: When speech is contaminated by high levels of additive noise, both its perceptual quality and its intelligibility are reduced. Studies show that conventional approaches to speech enhancement are able to improve quality but not intelligibility. However, in recent years, algorithms that estimate a time-frequency mask from noisy speech using a supervised machine learning approach and then apply this mask to the noisy speech have been shown to be capable of improving intelligibility. The most direct way of measuring intelligibility is to carry out listening tests with human test subjects. However, in situations where listening tests are impractical and where some additional uncertainty in the results is permissible, for example during the development phase of a speech enhancer, intrusive intelligibility metrics can provide an alternative to listening tests. This thesis begins by outlining a new intrusive intelligibility metric, WSTOI, that is a development of the existing STOI metric. WSTOI improves STOI by weighting the intelligibility contributions of different time-frequency regions with an estimate of their intelligibility content. The prediction accuracies of WSTOI and STOI are compared for a range of noises and noise suppression algorithms and it is found that WSTOI outperforms STOI in all tested conditions. The thesis then investigates the best choice of mask-estimation algorithm, target mask, and method of applying the estimated mask. A new target mask, the HSWOBM, is proposed that optimises a modified version of WSTOI with a higher frequency resolution. The HSWOBM is optimised for a stochastic noise signal to encourage a mask estimator trained on the HSWOBM to generalise better to unseen noise conditions. A high frequency resolution version of WSTOI is optimised as this gives improvements in predicted quality compared with optimising WSTOI. Of the tested approaches to target mask estimation, the best-performing approach uses a feed-forward neural network with a loss function based on WSTOI. The best-performing feature set is based on the gains produced by a classical speech enhancer and an estimate of the local voiced-speech-plus-noise to noise ratio in different time-frequency regions, which is obtained with the aid of a pitch estimator. When the estimated target mask is applied in the conventional way, by multiplying the speech by the mask in the time-frequency domain, it can result in speech with very poor perceptual quality. The final chapter of this thesis therefore investigates alternative approaches to applying the estimated mask to the noisy speech, in order to improve both intelligibility and quality. An approach is developed that uses the mask to supply prior information about the speech presence probability to a classical speech enhancer that minimises the expected squared error in the log spectral amplitudes. The proposed end-to-end enhancer outperforms existing algorithms in terms of predicted quality and intelligibility for most noise types.
Book Review Living Kinship, Fearing Spirits: Sociality among the Khmu of Northern Laos
Creators: name: Singh, Rana Abhyendra
Publisher: name: Zenodo
Year: 2022

description: Unlike other ethnographies, Rosalie Stolz’s Living Kinship, Fearing Spirits does not beat around the bush before introducing her readers to her project. She keeps her piece in the acknowledgment itself and informs beforehand of the parts of this book being drawn on previously published materials. She has written the whole book as a monograph presenting a detailed analysis of every ritual and custom that has taken place during her stay. Her book is situated against the backdrop of a village named Pliya, a small village in northern Laos wherein she resides with the Khmu tribe. She casts light upon their lifestyle, rituals, traditions, beliefs, and kinship. The word kinship is the keyword to the whole book, and Stolz has done justice to the word in her work. She begins the introduction by describing a scene in the midst of the harvest season, giving her readers a glimpse of another important word in her work: “spirits.” Stolz attempts to answer the following questions through this book: "Does consanguinity play a role here? Are totemic groups of relevance? What is entailed in the notion of family?" (p. 28).
description: https://www.iias.asia/the-review/living-kinship-fearing-spirits-sociality-among-khmu-northern-laos
The Tensor Network Theory Library
Creators: name: Al-Assam, Sarah
name: Clark, Stephen R.
name: Jaksch, Dieter
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: In this technical paper we introduce the Tensor Network Theory (TNT) library -- an open-source software project aimed at providing a platform for rapidly developing robust, easy to use and highly optimised code for TNT calculations. The objectives of this paper are (i) to give an overview of the structure of TNT library, and (ii) to help scientists decide whether to use the TNT library in their research. We show how to employ the TNT routines by giving examples of ground-state and dynamical calculations of one-dimensional bosonic lattice systems. We also discuss different options for gaining access to the software available at http://www.tensornetworktheory.org.
description: Updated to published version. 20 pages + 15 pages of appendices
(200957) Louis Cecil Ashby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Couverture vaccinale antigrippale des professionnels d’établissement d’hébergement pour personnes âgées dépendantes après sensibilisation par une équipe mobile d’hygiène
Creators: name: Trouilloud, Kae Ting
name: Amsellem-Dubourget, Sylvie
name: Lieutard, Martine
name: Ruban-Agniel, Françoise
name: Chapuis, Catherine
Publisher: name: Health & Co
Year: 2022
Subjects: Ehpad
Grippe
Vaccination du personnel
Action de formation
Personnel de santé
Campagne de prévention

description: La vaccination est le moyen le plus efficace pour prévenir la transmission de la grippe et ses complications. Elle est fortement recommandée pour les professionnels de santé exerçant dans les établissements d’hébergement pour personnes âgées dépendantes (Ehpad). Les professionnels expriment souvent une réticence à la vaccination. L’équipe mobile d’hygiène à destination des Ehpad (EMHE) a créé pour eux une action de sensibilisation. Elle se déplace afin de les rencontrer par sessions de 45 à 60 minutes. La sensibilisation donne une vision globale de la vaccination. Suit un temps d’échange permettant aux professionnels de partager leurs ressentis et de poser leurs questions sur la vaccination et les fake news. Nous comparons ici les données de couverture vaccinale sur trois ans (2016-2018) dans les établissements ayant bénéficié d’une sensibilisation en 2017 et 2018 avec celles des Ehpad n’y ayant pas recouru. Les 28 Ehpad avec sensibilisation avaient un taux moyen de 30,9% en 2016, 40% en 2017, et 53,8% en 2018. Leur taux d’augmentation de la couverture vaccinale est significativement plus important que celui des 7 Ehpad sans sensibilisation (30%, 36%, 44%). En comparaison, une enquête de Santé publique France estimait la couverture vaccinale nationale des professionnels d’Ehpad à 31,9% en France et à 33% en Auvergne-Rhône-Alpes pour la saison 2018-2019. L’impact dépend de l’établissement, celui-ci devant accompagner les professionnels dans cette démarche. Cette évolution favorable du taux de vaccination post-sensibilisation laisse espérer une même dynamique lors des prochaines campagnes vaccinales (antigrippale ou autre).
Chemical probes for GPCRs: investigating GPR119
Creators: name: Hadavizadeh, Kate Shirin
Publisher: name: Imperial College London
Year: 2019

description: GPCRs are one of the most important classes of proteins within the arena of drug discovery and therapeutics. They are involved in transmitting external stimuli across the cell membrane to elicit intracellular responses that can alter gene activation, protein synthesis and messenger signalling that can be intrinsic to health and disease. GPR119 is a GPCR shown to be involved in glucose-dependent insulin secretion with expression in the pancreatic β-cells and intestinal K- and L-cells, implicating the protein as a potential therapeutic target for type 2 diabetes. There have been many agonists published for GPR119, however none have progressed further than phase II clinical trials, largely due to lack of efficacy. This thesis focuses on the synthesis and evaluation of chemical probes for GPR119 based on agonists developed by AstraZeneca, with differing pharmacophores exhibiting both on-target GPR119 mediated blood glucose lowering, and off-target GPR119 independent blood glucose lowering. Modifying the pharmacophores with diazirine photoreactive groups and alkyne click chemistry handles, a library of probes was synthesised. Probes exhibited a range of potencies for GPR119, with the most potent having an EC50 in the nanomolar range. Within this thesis, the challenges of working with GPCRs are addressed: expression and identification of GPR119 protein is a difficulty encountered both within the literature and during this study. By exploring the use of epitope tags and fusion proteins, GPR119 expression was detectable using fluorescence and immunoblotting techniques. The generation of a HaloTag-GPR119 construct enabled the identification of GPR119 using proteomic methods, which has not previously been reported. By utilising the biological tools for GPR119, evaluation of the chemical photocrosslinking probes for GPR119 was possible in cell lines over expressing HaloTag-GPR119. Dual fluorescent labelling of the protein and probe, alongside immunoblotting identified a chemical probe showing response to competition with the parent compound, presenting a potential chemical probe for GPR119.
title: Equipment leasing in the Nigerian banking environment: a legal perspective
Creators: name: Amasike, Chukwudi Joseph
Publisher: name: University of Kent
Year: 2022

description: There is today a great variety of economic ventures in Nigeria needing huge capital resources for their development. These ventures usually require very expensive equip­ment which financially cannot easily be acquired by people who need it. Even where they can afford to do so they generally would not like to purchase it as doing so would not only tie down their capital but also saddle them with equipment they probably only require to carry out a specific project. But since the businessman or industrialist must use the equipment for the execution of his business, an alternative source of financing has to be found, and equipment leasing has been found to be the most attractive. Even though equipment leasing was introduced in Nigeria only in the early 1960’s, it has grown into a multi-billion naira business in less than three decades and has generated a special interest in the Nigerian banking institutions, among others. Despite the huge scope and size of the industry, it is unfortunate to note that this commercial activity is very much misunderstood by the general public and the operators, and worse still there is no adequate and / or specific legislative structure governing it. The effect of this is that the industry is developing in very many directions. This thesis therefore attempts to examine fully the legal perspective of this mode of financing within the Nigerian banking environment, with a view to stream-lining the operations or providing some sense of direction in this highly lucrative and vibrant commercial activity.
An examination of the importance of compassionate love and self-esteem for engaging in relationship repair behaviour
Creators: name: Zapral, Anna
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Psychology in Clinical Psychology to the School of Psychological Science, Faculty of Science, Technology, and Engineering, La Trobe University, Bundoora.

This thesis examined the association of compassionate love and self-esteem with engagement in positive interactions following conflict in a romantic relationship. Repair behaviour occurs when there is engagement in behaviour that encourages resolution during a conflict, such as acting in a way to strengthen the relationship, or not viewing the partner negatively. This research is an extension of work investigating the association of self-esteem and interactions in romantic relationships and the relatively new field of compassionate love. Two on-line studies were completed, with results indicating that repair behaviour is influenced by compassionate love and self-esteem. Both studies were completed by male and female participants who were currently in a romantic relationship, representing a broad sample of the population. The first study (N = 300) investigated how people responded to conflict within their romantic relationships, and also whether compassionate love had a moderator effect between self-esteem and repair behaviour. Results suggested that high selfesteem and high compassionate love results in a greater likelihood to engage in repair behaviour following a conflict. Compassionate love was not found to moderate between selfesteem and repair behaviour. The second study (N = 486) included an experimental manipulation, via a hypothetical conflict scenario, to which participants responded while thinking either of themselves or of an imagined partner. The hypothesis that compassionate love can be primed, with the technique used in this study, was not supported. Results from both studies identified the importance of demonstrating compassionate love for one's partner in order to engage in repair behaviour following a conflict, as well as the importance of possessing high implicit self-esteem. This has clinical implications for couples therapy, as compassionate love may help to overcome possible destructive reactions in behaviours during conflict in a romantic relationship.
Inhibition of a conserved DNA repair complex promotes susceptibility of Staphylococcus aureus to host defences
Creators: name: Ha, Kam Pou
Publisher: name: Imperial College London
Year: 2019

description: Staphylococcus aureus is a leading cause of serious infections in humans, but treatment can be ineffective due to the emergence of antibiotic-resistant strains. During infection, the most important host defence mechanism against Staphylococcus aureus is the oxidative burst of neutrophils, which involves the rapid generation and release of reactive oxygen species. However, whilst it has been hypothesised that DNA is an important target of the oxidative burst, this had not been tested. Work described in this thesis revealed that the neutrophil oxidative burst triggers the SOS DNA repair pathway in phagocytosed S. aureus, indicating that staphylococcal DNA is a target of the host immune response. A screen of a panel of mutants defective in various DNA repair processes revealed that the RexAB complex was essential for maximal staphylococcal survival in whole human blood, during incubation with purified human neutrophils and during invasive murine infection. This repair complex also conferred a survival benefit to Streptococcus gordonnii and Enterococcus faecalis in human blood, indicating that DNA is a conserved target of neutrophil-mediated killing. Using recombinant S. aureus RexAB, it was demonstrated that this complex is a functional member of the AddAB family of helicase-nuclease enzymes, required for the repair of DNA double-strand breaks. In an effort to develop inhibitors of RexAB for use as potential therapeutics, subsequent work identified a compound that potentiated the activity of DNA-damaging antibiotics. However, it was not possible to demonstrate inhibition of RexAB. In summary, these data demonstrate that RexAB is required for staphylococcal survival during infection by repairing DNA damage caused by the neutrophil oxidative burst. Future work will focus on the discovery and development of small-molecule inhibitors of RexAB that could be used therapeutically to sensitise S. aureus to host immune defences.
Formation and settling of a disc galaxy during the last 8 billion years in a cosmological simulation
Creators: name: Ceverino, Daniel
name: Primack, Joel
name: Dekel, Avishai
name: Kassin, Susan A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present results of a high-resolution zoom cosmological simulation of the evolution of a low-mass galaxy with a maximum velocity of V=100 km/s at z=0, using the initial conditions from the AGORA project (Kim et al. 2014). The final disc-dominated galaxy is consistent with local disc scaling relations, such as the stellar-to-halo mass relation and the baryonic Tully-Fisher. The galaxy evolves from a compact, dispersion-dominated galaxy into a rotation-dominated but dynamically hot disc in about 0.5 Gyr (from z=1.4 to z=1.2). The disc dynamically cools down for the following 7 Gyr, as the gas velocity dispersion decreases over time, in agreement with observations. The primary cause of this slow evolution of velocity dispersion in this low-mass galaxy is stellar feedback. It is related to the decline in gas fraction, and to the associated gravitational disk instability, as the disc slowly settles from a global Toomre Q>1 turbulent disc to a marginally unstable disc (Q=1).
description: 9 pages, 11 figures, minor changes, accepted at MNRAS
Desiring the Undesirable: Preservation, Provenance and the Politics of Display
Creators: name: Santilla, Maree
Publisher: name: La Trobe
Year: 2023

description: Submission note: Exegesis submitted In partial fulfilment of the requirement of Master of Visual Art Research to the School of Humanities and Social Sciences, College of Arts, Social Sciences and Commerce, La Trobe University, Victoria.

Due to file size, this video may take time to download.

Practice-based thesis.
Impact of SARS-CoV-2 3CL Protease Mutations on Nirmatrelvir Inhibitory Efficiency. Computational Insights into Potential Resistance Mechanisms
Creators: name: Ramos-Guzmán, Carlos A.
name: Andjelkovic, Milorad
name: Zinovjev, Kirill
name: Ruiz-Pernía, J. Javier
name: Tuñón, Iñaki
Publisher: name: Zenodo
Year: 2022
Subjects: SARS-CoV-2; main protease; 3CL protease; mutations; QM/MM; free energy

description: Study of the SARS-CoV-2 3CL Protease Mutations on Nirmatrelvir inhibitor This upload contain: Article preprint PDB files. Snapshots from 10 ps Molecular Dynamics simulations at M062x level of the Transition State of the enzyme-inhibitor (EI) complex in the: Wild type system E166V mutant system VMD visualisation file
(200958) Lionel Finch Ashby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The role of self-esteem in intergroup behaviour
Creators: name: Andreopoulou, Alexia
Publisher: name: University of Kent
Year: 2022

description: The aim of this thesis was to explore ways of testing social identity theory’s (Tajfel & Turner 1979) “self-esteem hypothesis”. Abrams and Hogg (1988) identified two corollaries of the self-­esteem hypothesis. The first is that successful intergroup discrimination enhances social identity and thus elevates self-esteem. The second suggests that, because of a motivational need for positive self-esteem, low self-esteem will motivate intergroup discrimination. The self-esteem hypothesis is one the most controversial issues of social identity theory in terms of the diverse findings obtained from studies conducted in this area. The empirical evidence remains equivocal for either corollary. In this thesis it was argued that the lack of firm empirical support for the self-esteem hypothesis may be due to misunderstandings related to design, measurement of self-esteem, and type of groups employed. This thesis examined these issues and studies were conducted to address them. Laboratory and real group studies were conducted. It was found that even when issues related to design, measurement, and type of groups were taken into consideration, there were additional factors which play an important role in testing the self­-esteem hypothesis. There was support for corollary two of the self-esteem hypothesis when real groups were employed and intergroup discrimination was operationalised as outgroup derogation and not as ingroup bias. Corollary one was supported when intergroup evaluations had an important outcome for the group and when the attributes of intergroup evaluations were positive. The implications of the findings of this thesis are discussed in the context of social identity theory and avenues for future research are suggested.
Time-domain Boundedness of Noise-to-State Exponentially Stable Systems
Creators: name: Fang, Zhou
name: Gao, Chuanhou
Publisher: name: arXiv
Year: 2016
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 93E15, 60H10

description: In this paper we prove the time-domain boundedness for noise-to-state exponentially stable systems, and further make an estimation of its lower bound function, which allows to answer the question that how long the solution of a stochastic noise-to-state exponentially stable system stays in the domain of attraction and what happens with it if it escapes from this region for a while. The results will complement the probability-domain boundedness of noise-to-state exponentially stable systems, and provide a new insight into noise-to-state exponential stability.
(200959) William Stuckey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: From tradition to modernism: British landscape painting in the postwar period
Creators: name: Antal Mavity, Imola
Publisher: name: University of Kent
Year: 2022

description: In the immediate aftermath of the war which threatened sovereignty, fractured geographical and political identities and cultures and left the land scarred and damaged, landscape became invested with deep and special significance. During this time, Romanticism unsurprisingly re-flourished and the first psychological accounts of the phenomenology of place and space started appearing. Landscape painting became a visual manifestation of national identity which had acquired a great meaning in these circumstances. Whilst relying on established notions of the British visual tradition, the introspective nature of wartime Neo-Romanticism ultimately allowed for the liberation of landscape painting from ideological constraints and the ease with which it assimilated modernism. War not only strengthened the idea of place and the landscape as a redemptive genre, but equally, in a counter direction, it encouraged the idea that art should set itself apart from society entirely, either as a perceptual investigation divorced from social enquiry, or as complete formalism. Modernism had brought a new emphasis on aesthetic appreciation and a reaction against mythical, historical and narrative tendencies in traditional landscapes. The work of Monet and Cézanne was redefined in a contemporary context and British artists, such as Lanyon, Heron and Frost, influenced by European and American postwar modernist models started experimenting with new approaches to landscape. In view of these foreign influences, the need to establish the existence of a strong, innovative home-grown avant-garde became imperative. As institutional support in the arts increased, regional cultural communities such as St Ives were rejuvenated and British art started being promoted abroad. This thesis demonstrates that landscape painting was an enduring and adaptable genre which significantly contributed to the integration of British art into modernism.
New constraints on the average escape fraction of Lyman continuum radiation in z~4 galaxies from the VIMOS Ultra Deep Survey (VUDS)
Creators: name: Marchi, F.
name: Pentericci, L.
name: Guaita, L.
name: Ribeiro, B.
name: Castellano, M.
name: Schaerer, D.
name: Hathi, N. P.
name: Lemaux, B. C.
name: Grazian, A.
name: Fevre, O. Le
name: Garilli, B.
name: Maccagni, D.
name: Amorin, R.
name: Bardelli, S.
name: Cassata, P.
name: Fontana, A.
name: Koekemoer, A. M.
name: Brun, V. Le
name: Tasca, L. A. M.
name: Thomas, R.
name: Vanzella, E.
name: Zamorani, G.
name: Zucca, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Determining the average fraction of Lyman continuum (LyC) photons escaping high redshift galaxies is essential for understanding how reionization proceeded in the z>6 Universe. We want to measure the LyC signal from a sample of sources in the Chandra Deep Field South (CDFS) and COSMOS fields for which ultra-deep VIMOS spectroscopy as well as multi-wavelength Hubble Space Telescope (HST) imaging are available. We select a sample of 46 galaxies at $z\sim 4$ from the VIMOS Ultra Deep Survey (VUDS) database, such that the VUDS spectra contain the LyC part of the spectra, that is, the rest-frame range $880-910Å$. Taking advantage of the HST imaging, we apply a careful cleaning procedure and reject all the sources showing nearby clumps with different colours, that could potentially be lower-redshift interlopers. After this procedure, the sample is reduced to 33 galaxies. We measure the ratio between ionizing flux (LyC at $895Å$) and non-ionizing emission (at $\sim 1500 Å$) for all individual sources. We also produce a normalized stacked spectrum of all sources. Assuming an intrinsic average $L_ν(1470)/L_ν(895)$ of 3, we estimate the individual and average relative escape fraction. We do not detect ionizing radiation from any individual source, although we identify a possible LyC emitter with very high Ly$α$ equivalent width (EW). From the stacked spectrum and assuming a mean transmissivity for the sample, we measure a relative escape fraction $f_{esc}^{rel}=0.09\pm0.04$. We also look for correlations between the limits in the LyC flux and source properties and find a tentative correlation between LyC flux and the EW of the Ly$α$ emission line. Our results imply that the LyC flux emitted by $V=25-26$ star-forming galaxies at z$\sim$4 is at most very modest, in agreement with previous upper limits from studies based on broad and narrow band imaging.
description: accepted by A&A updated fesc,rel value
title: Familien in Zahlen 2022
title: Statistische Informationen zu Familien in Österreich
titleType: Subtitle
Creators: name: Kaindl, Markus
name: Schipfer, Rudolf Karl
Publisher: name: University of Vienna. Project: Family Studies in Austria
Year: 2023
Subjects: Familienforschung
Familienstatistik
Sozialstatistik
Bevölkerungsstatistik

description: Familien in Zahlen (FiZ), die bewährte Zusammenstellung familienrelevanter Statistiken, wurde 2022 aktualisiert und zeigt die Veränderungen von Kennzahlen in den letzten zehn Jahren. Enthalten sind Daten zu Themen wie zum Beispiel Geburten und Fertilität, Haushalts- und Familienformen, Erwerbstätigkeit, Kinderbetreuung sowie europäische Vergleichsdaten. Die Tabellen sind mit Lesebeispielen versehen und ein Glossar erklärt familienstatistische Fachausdrücke. Die Auswirkungen der COVID-19-Pandemie auf familienbezogene Kennzahlen werden in einem Sonderkapitel dargestellt.
Cohesion establishment by yeast Replication Factor C (RFC) complexes
Creators: name: Liu, Hon Wing
Publisher: name: Imperial College London
Year: 2019

description: Concomitant with DNA replication, sister chromatid cohesion is established to ensure faithful chromosome segregation. This is mediated by the ring-shaped cohesin complex. In Saccharomyces cerevisiae, cohesin is loaded onto chromosomes during G1 but its residence on DNA is not long-lasting. During S phase, the cohesin subunit Smc3 is acetylated by the acetyltrans¬ferase Eco1 to achieve long-lasting residence on DNA. This reaction is facilitated by multiple replication fork factors including the alternative PCNA loader RFCCtf18 complex, a member of the PCNA-RFC family of clamp loaders/unloaders that also include PCNA loader RFCRfc1 and PCNA unloader RFCElg1. RFCCtf18 is an enigmatic component of the replication machinery that is known to interact with leading strand Pol ε and has important roles in both establishing sister chromatid cohesion and maintaining replication checkpoint. How RFCCtf18 facilitates cohesion establishment, and whether PCNA loading is involved, remain unresolved. I reveal that PCNA loading by RFCCtf18 is required for cohesion establishment separately from its checkpoint function and independent from its interaction with Pol ε. I uncover post-replication lagging strand PCNA is important for cohesion establishment. I also determined that the prototypic PCNA loader RFCRfc1 is not a cohesion establishment factor, but is instead required for replication progression. Through a strand-specific approach, I reveal that RFCCtf18 and RFCRfc1 preferentially bind to and load separate pools of PCNA on the leading and lagging strands respectively. Rfc1 and Ctf18 therefore play divergent strand-specific roles at the replication fork. Loaded pools of PCNA on the leading and lagging strands are unequal and confer distinct molecular functions. Since lagging strand RFCRfc1 is not important for cohesion, and that leading strand RFCCtf18 is, I propose more complex mechanisms for RFCCtf18’s role in cohesion establishment.
Limits on the Cosmological Abundance of Supermassive Compact Objects from a Search for Multiple Imaging in Compact Radio Sources
Creators: name: Augusto, P.
name: Browne, I. W. A.
name: Henstock, D. R.
name: Pearson, T. J.
name: Polatidis, A. G.
name: Readhead, A. C. S.
name: Taylor, G. B.
name: Vermeulen, R. C.
name: Wilkinson, P. N.
name: Xu, W.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
Level-set percolation for the Gaussian free field on a transient tree
Creators: name: Abächerli, Angelo
name: Sznitman, Alain-Sol
Publisher: name: arXiv
Year: 2016
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60K35, 60G15, 60J10, 60J80, 82B43

description: We investigate level-set percolation of the Gaussian free field on transient trees, for instance on super-critical Galton-Watson trees conditioned on non-extinction. Recently developed Dynkin-type isomorphism theorems provide a comparison with percolation of the vacant set of random interlacements, which is more tractable in the case of trees. If $h_*$ and $u_*$ denote the respective (non-negative) critical values of level-set percolation of the Gaussian free field and of the vacant set of random interlacements, we show here that $h_* < \sqrt{2u}_*$ in a broad enough set-up, but provide an example where $0 = h_* = u_*$ occurs. We also obtain some sufficient conditions ensuring that $h_* > 0$.
description: 34 pages, this version appears in the Annales Institut Henri Poincar\'e Probabilit\'es et Statistiques
Nutritional and neuroprotective characterization of 'Tadanishiki' yuzu according to harvesting period or extraction condition
Creators: name: Lee, Bo-Bae
name: Kim, Young-Min
name: Nam, Seung-Hee
Publisher: name: Journal of Applied Botany and Food Quality
Year: 2022

description: The present study investigated the phenolic profile, antioxidant activity, and neuroprotective properties of ‘Tadanishiki’ yuzu (Citrus junos, a seedless variety of yuzu) according to harvesting period and extraction condition. High-performance liquid chromatography (HPLC) was used to identify the functional components. To evaluate the neuroprotective properties, scopolamine was used to induce cholinergic dysfunction in human neuroblastoma SH-SY5Y cells pretreated with yuzu extracts. Among the harvesting periods, September provided the optimum fruit weight of yuzu and relatively high amounts of total phenolics (3.67 mg/g DW), flavonoids (10.13 mg/g DW), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity (29.10 μg Vit. C eq.). Of the functional compounds, hesperidin (13.57 mg/100 g DW) and naringin (5.84 mg/100 g DW) were the highest in 5% (w/v) yuzu extracted with 80% ethanol and this extract showed the highest DPPH (289.2 μg Vit. C eq.) scavenging activity. This same extract showed the highest cell viability and lowest cortisol or acetylcholinesterase content in scopolamine-treated SH-SY5Y cells. These results indicate that ‘Tadanishiki’ yuzu harvested in September should be extracted at 5% (w/v) yuzu with 80% EtOH, and this extract might be useful for application as a natural functional additive.
description: Journal of Applied Botany and Food Quality, Vol. 95 (2022): Journal of Applied Botany and Food Quality
(200960) Leslie Francis Montague Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Composition and immunogenicity of virulence complexes on the surface of erythrocytes infected with the malaria parasite Plasmodium falciparum
Creators: name: Fobes, Elmar Tilo
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora.

Malaria is a disease that has plagued humanity for millennia and is still threatening a large part of the population on earth causing major health problems, most prominently in the developing world. The causative agent, protozoan parasites of the genus Plasmodium, infects a wide range of host animals, from birds and reptiles to monkeys and mice. They [sic] are more than 200 species in the Plasmodium genus and 5 of these are reported to infect humans: P. falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. These are all transmitted by the bite of a female Anopheles mosquito and the most severe cases are attributed to infections with P.falciparum and less [sic] deaths confirmed from P.vivax infections.
SMASH 1: a very faint globular cluster disrupting in the outer reaches of the LMC?
Creators: name: Martin, Nicolas F.
name: Jungbluth, Valentin
name: Nidever, David L.
name: Bell, Eric F.
name: Besla, Gurtina
name: Blum, Robert D.
name: Cioni, Maria-Rosa L.
name: Conn, Blair C.
name: Kaleida, Catherine C.
name: Gallart, Carme
name: Jin, Shoko
name: Majewski, Steven R.
name: Martinez-Delgado, David
name: Monachesi, Antonela
name: Mñoz, Ricardo R.
name: Noël, Noelia E. D.
name: Olsen, Knut
name: Olszewski, Edward W.
name: Stringfellow, Guy S.
name: van der Marel, Roeland P.
name: Vivas, A. Katherina
name: Walker, Alistair R.
name: Zaritsky, Dennis
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the discovery of a very faint stellar system, SMASH 1, that is potentially a satellite of the Large Magellanic Cloud. Found within the Survey of the MAgellanic Stellar History (SMASH), SMASH 1 is a compact ($r_h = 9.1^{+5.9}_{-3.4}$ pc) and very low luminosity (M_V = -1.0 +/- 0.9, $L_V=10^{2.3 +/- 0.4}$ Lsun) stellar system that is revealed by its sparsely populated main sequence and a handful of red-giant-branch candidate member stars. The photometric properties of these stars are compatible with a metal-poor ([Fe/H]=-2.2) and old (13 Gyr) isochrone located at a distance modulus of ~18.8, i.e. a distance of ~57 kpc. Situated at 11.3$^\circ$ from the LMC in projection, its 3-dimensional distance from the Cloud is ~13 kpc, consistent with a connection to the LMC, whose tidal radius is at least 16 kpc. Although the nature of SMASH 1 remains uncertain, its compactness favors it being a stellar cluster and hence dark-matter free. If this is the case, its dynamical tidal radius is only <19 pc at this distance from the LMC, and smaller than the system's extent on the sky. Its low luminosity and apparent high ellipticity ($ε=0.62^{+0.17}_{-0.21}$) with its major axis pointing toward the LMC may well be the tell-tale sign of its imminent tidal demise.
description: 7 pages, 4 figures, 1 table. Accepted for publication in ApJL. v2: corrected figure 4 in which rh for globular clusters were miscalculated. The updated figure reflect the published version of the paper
Quantum and semiclassical aspects of Lindblad dynamics
Creators: name: Longstaff, Bradley
Publisher: name: Imperial College London
Year: 2019

description: The Lindblad equation is commonly used to model dissipation and decoherence in open quantum systems. Yet many of the properties of Lindblad dynamics are still little understood. This thesis explores various aspects of the Lindblad equation and its connections with non-Hermitian quantum theories. The evolution speed of Lindblad dynamics is investigated and an explicit expression for the speed is derived. The radial component, connected to the rate at which the purity of the state changes, is shown to be determined by the modified skew information of the Lindblad operators. The semiclassical time evolution of Gaussian states under Lindblad dynamics is then considered and a new type of phase-space dynamics is derived for the centre of a Gaussian Wigner function. By viewing the phase-space Lindblad equation as a Schroedinger equation with a non-Hermitian Hamiltonian, a further set of semiclassical equations are derived. These can describe the interference terms in Wigner functions. Further, a PT-symmetric two-level system driven through two consecutive exceptional points at finite speed is considered and an analytical expression for the probability of a non-adiabatic transition is derived. It is shown that the transition through the exceptional points can be experimentally addressed in a PT-symmetric lattice using Bloch oscillations. Finally, a quantum implementation of this PT-symmetric system using ultracold atoms in an optical lattice with single-particle losses is investigated.
(200955) William Grover Ashby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Multi-Boson Interactions at the LHC
Creators: name: Green, Daniel R.
name: Meade, Patrick
name: Pleier, Marc-Andre
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This review covers results on the production of all possible electroweak boson pairs and 2-to-1 vector boson fusion at the CERN Large Hadron Collider (LHC) in proton-proton collisions at a center of mass energy of 7 and 8 TeV. The data were taken between 2010 and 2012. Limits on anomalous triple gauge couplings (aTGCs) then follow. In addition, data on electroweak triple gauge boson production and 2-to-2 vector boson scattering yield limits on anomalous quartic gauge boson couplings (aQGCs). The LHC hosts two general purpose experiments, ATLAS and CMS, which have both reported limits on aTGCs and aQGCs which are herein summarized. The interpretation of these limits in terms of an effective field theory is reviewed, and recommendations are made for testing other types of new physics using multi-gauge boson production.
description: 53 pages, 48 figures, 4 tables
Properties of Generalized Freud Polynomials
Creators: name: Clarkson, Peter A
name: Jordaan, Kerstin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 33C47, 34M55, 65Q99

description: We consider the semi-classical generalized Freud weight function \[w_λ(x;t) = |x|^{2λ+1}\exp(-x^4 +tx^2),\qquad x\in\mathbb{R},\] with $ λ>-1$ and $t\in\mathbb{R}$ parameters. We analyze the asymptotic behavior of the sequences of monic polynomials that are orthogonal with respect to $w_λ(x;t)$, as well as the asymptotic behavior of the recurrence coefficient, when the degree, or alternatively, the parameter $t$, tend to infinity. We also investigate existence and uniqueness of positive solutions of the nonlinear difference equation satisfied by the recurrence coefficients and prove properties of the zeros of the generalized Freud polynomials.
description: 26 pages, 8 figures
Landscape mapping of adaptive building skin - prevailing solutions in market and in research
Creators: name: Artopoulos, Georgios
name: Charalambous, Magdalene
Publisher: name: Zenodo
Year: 2022
Subjects: Adaptive Architecture Systems
Building Skins
Retrofit
Sustainable Design

description: AAS MESH presentation at the TIMEPAC 2022 International Workshop with the title ‘Enhancing Energy Performance Certification to Drive the Deep Renovation of Europe’s Building stock’, organised by Politecnico di Torino for TIMEPAC (Towards Innovative Methods for Energy Performance Assessment and Certification of Buildings), a Horizon 2020 research project. The presentation had the title “Landscape mapping of adaptive building skin – prevailing solution in the market and in research” and it was a presentation of some of the results from the market research that was conducted for the project. The aim of this presentation was to inform the participants about the European landscape of advanced building skin solutions for reshaping the existing building inventory towards enhanced energy efficiency and fortified climate resilience, achieved through strategic renovations and inform of the development of MESH.
title: Reflektieren lernen
title: Hochschuldidaktische Praxisbegleitung von Tutor/inn/en
titleType: AlternativeTitle
Creators: name: Gotzen, Susanne
Publisher: name: Hochschuldidaktisches Zentrum der Technischen Universität Dortmund
Year: 2008
Subjects: subject: 370

description: Journal Hochschuldidaktik ; 19. Jahrgang 2008 Heft 2
(200956) Louisa Ashby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Teilvirtuelle Tutorien
title: Qualifizierung für studentische Beratungs- und Begleitungstätigkeiten am HDZ Dortmund
titleType: AlternativeTitle
Creators: name: Fisseler, Björn
name: Szczyrba, Birgit
Publisher: name: Hochschuldidaktisches Zentrum der Technischen Universität Dortmund
Year: 2006
Subjects: subject: 370

description: Tutoring, Mentoring und Peer Consulting: Studentische Beratungstätigkeiten erfüllen traditionell eine wichtige Funktion im Studium (vgl. im Überblick Wildt/Szczyrba/Wildt 2006). Im Rahmen von Studienreformprojekten und Initiativen zur Verbesserung der Studiensituation werden sie nun verstärkt an den Hochschulen nachgefragt. In einigen Fällen werden diese Tätigkeiten durch entsprechende Strukturen wie Werkverträge konfiguriert. Im Zuge der Einführung neuer Studiengänge werden sie flächendeckend in das Studium integriert und als Studienleistungen per credits anerkannt. Die im Folgenden beschriebenen teilvirtuellen Tutorien stellen eine lehrveranstaltungsbegleitende Maßnahme des HDZ dar, deren Besonderheiten in drei Aspekten zu sehen sind: In der Projektbegleitung und Supervision der für die Tutorien verantwortlichen Lehrenden, in der Qualifizierung der Tutor/inn/en sowie in der Integration einer E-Learning-Komponente.
description: Journal Hochschuldidaktik ; 17. Jahrgang 2006 Heft 1