cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
การพัฒนาทักษะการอ่านจับใจความ ของนักเรียนชั้นมัธยมศึกษาปีที่ 3 โดยใช้แบบฝึกทักษะการอ่านจับใจความร่วมกับบทเรียนผ่าน Web Application genially
Creators: name: ทวีนันท์ พันอุสาห์
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยกาฬสินธุ์
Year: 2023
Subjects: ทักษะการอ่านจับใจความ
บทเรียนผ่าน Web Application genially
แบบฝึกทักษะ

description: วารสารมนุษยศาสตร์ สังคมศาสตร์ และนวัตกรรม มหาวิทยาลัยกาฬสินธุ์, 2, 1, 26-35
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
Creators: name: Zhang, Yi
name: Okada, Yuki
name: Kallin, Eric M.
name: Tateishi, Keisuke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Recent studies indicate that the methylation state of histones can be dynamically regulated by histone methyltransferases and demethylases1,2. The H3K9-specific demethylase Jhdm2a (also known as Jmjd1a and Kdm3a) has an important role in nuclear hormone receptor-mediated gene activation and male germ cell development3,4. Through disruption of the Jhdm2a gene in mice, here we demonstrate that Jhdm2a is critically important in regulating the expression of metabolic genes. The loss of Jhdm2a function results in obesity and hyperlipidemia in mice. We provide evidence that the loss of Jhdm2a function disrupts β-adrenergic-stimulated glycerol release and oxygen consumption in brown fat, and decreases fat oxidation and glycerol release in skeletal muscles. We show that Jhdm2a expression is induced by β-adrenergic stimulation, and that Jhdm2a directly regulates peroxisome proliferator-activated receptor α (Ppara) and Ucp1 expression. Furthermore, we demonstrate that β-adrenergic activation-induced binding of Jhdm2a to the PPAR responsive element (PPRE) of the Ucp1 gene not only decreases levels of H3K9me2 (dimethylation of lysine 9 of histone H3) at the PPRE, but also facilitates the recruitment of Pparγ and Rxrα and their co-activators Pgc1aα(also known as Ppargc1a), CBP/ p300 (Crebbp) and Src1 (Ncoa1) to the PPRE. Our studies thus demonstrate an essential role for Jhdm2a in regulating metabolic gene expression and normal weight control in mice.
Background sky obscuration by cluster galaxies as a source of systematic error for weak lensing
Creators: name: Simet, Melanie
name: Mandelbaum, Rachel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Lensing magnification and stacked shear measurements of galaxy clusters rely on measuring the density of background galaxies behind the clusters. The most common ways of measuring this quantity ignore the fact that some fraction of the sky is obscured by the cluster galaxies themselves, reducing the area in which background galaxies can be observed. We discuss the size of this effect in the Sloan Digital Sky Survey (SDSS) and the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS), finding a minimum 1 per cent effect at $0.1h^{-1}$Mpc from the centers of clusters in SDSS; the effect is an order of magnitude higher in CFHTLenS. The resulting biases on cluster mass and concentration measurements are of the same order as the size of the obscuration effect, which is below the statistical errors for cluster lensing in SDSS but likely exceeds them for CFHTLenS. We also forecast the impact of this systematic error on cluster mass and magnification measurements in several upcoming surveys, and find that it typically exceeds the statistical errors. We conclude that future surveys must account for this effect in stacked lensing and magnification measurements in order to avoid being dominated by systematic error.
description: 12 pages, 14 figures
The DNA-encoded nucleosome organization of a eukaryotic genome
Creators: name: Field, Yair
name: Lieb, Jason D.
name: Gossett, Andrea J.
name: Tillo, Desiree
name: Moore, Irene K.
name: Kaplan, Noam
name: Fondufe-Mittendorf, Yvonne
name: LeProust, Emily M.
name: Hughes, Timothy R.
name: Segal, Eran
name: Widom, Jonathan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Nucleosome organization is critical for gene regulation1. In living cells this organization is determined by multiple factors, including the action of chromatin remodellers2, competition with site-specific DNA-binding proteins3, and the DNA sequence preferences of the nucleosomes themselves4-8. However, it has been difficult to estimate the relative importance of each of these mechanisms in vivo7,9-11, because in vivo nucleosome maps reflect the combined action of all influencing factors. Here we determine the importance of nucleosome DNA sequence preferences experimentally by measuring the genome-wide occupancy of nucleosomes assembled on purified yeast genomic DNA. The resulting map, in which nucleosome occupancy is governed only by the intrinsic sequence preferences of nucleosomes, is similar to in vivo nucleosome maps generated in three different growth conditions. In vitro, nucleosome depletion is evident at many transcription factor binding sites and around gene start and end sites, indicating that nucleosome depletion at these sites in vivo is partly encoded in the genome. We confirm these results with a micrococcal nuclease-independent experiment that measures the relative affinity of nucleosomes for ∼40,000 double-stranded 150-base-pair oligonucleotides. Using our in vitro data, we devise a computational model of nucleosome sequence preferences that is significantly correlated with in vivo nucleosome occupancy in Caenorhabditis elegans. Our results indicate that the intrinsic DNA sequence preferences of nucleosomes have a central role in determining the organization of nucleosomes in vivo.
Diffusion-desorption ratio of adsorbed CO and CO$_2$ on water ice
Creators: name: Karssemeijer, L. J.
name: Cuppen, H. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Diffusion of atoms and molecules is a key process for the chemical evolution in the star forming regions of the interstellar medium. Accurate data on the mobility of many important interstellar species is however often not available and this provides a serious limitation for the reliability of models describing the physical and chemical processes in molecular clouds. Here we aim to provide the astrochemical modeling community with reliable data on the ratio between the energy barriers for diffusion and desorption for adsorbed CO and CO$_2$ on water ices. To this end, we use a fully atomistic, off-lattice kinetic Monte Carlo technique to generate dynamical trajectories of CO and CO$_2$ molecules on the surface of crystalline ice at temperatures relevant for the interstellar medium. The diffusion to desorption barrier ratios are determined to be 0.31 for CO and 0.39 for CO$_2$ . These ratios can be directly used to improve the accuracy of current gas-grain chemical models.
description: 4 pages, 3 figures, accepted for publication in Astronomy & Astrophysics
Unlocking the secrets of the genome
Creators: name: White, Kevin P.
name: Henikoff, Steven
name: Piano, Fabio
name: Micklem, Gos
name: Waterston, Robert H.
name: Lai, Eric C.
name: Lieb, Jason D.
name: Celniker, Susan E.
name: Kellis, Manolis
name: Snyder, Michael
name: MacAlpine, David M.
name: Gunsalus, Kristin C.
name: Karpen, Gary H.
name: Dillon, Laura A. L.
name: Gerstein, Mark B.
name: Stein, Lincoln
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Despite the successes of genomics, little is known about how genetic information produces complex organisms. A look at the crucial functional elements of fly and worm genomes could change that.
Surface-integral formalism of deuteron stripping
Creators: name: Mukhamedzhanov, A. M.
name: Pang, D. Y.
name: Bertulani, C. A.
name: Kadyrov, A. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The purpose of this paper is to develop an alternative theory of deuteron stripping to resonance states based on the surface integral formalism of Kadyrov et al. [Ann. Phys. 324, 1516 (2009)] and continuum-discretized coupled channels (CDCC). First we demonstrate how the surface integral formalism works in the three-body model and then we consider a more realistic problem in which a composite structure of target nuclei is taken via optical potentials. We explore different choices of channel wave functions and transition operators and show that a conventional CDCC volume matrix element can be written in terms of a surface-integral matrix element, which is peripheral, and an auxiliary matrix element, which determines the contribution of the nuclear interior over the variable $r_{nA}$. This auxiliary matrix element appears due to the inconsistency in treating of the $n-A$ potential: this potential should be real in the final state to support bound states or resonance scattering and complex in the initial state to describe $n-A$ scattering. Our main result is formulation of the theory of the stripping to resonance states using the prior form of the surface integral formalism and CDCC method. It is demonstrated that the conventional CDCC volume matrix element coincides with the surface matrix element, which converges for the stripping to the resonance state. Also the surface representation (over the variable $r_{nA}$ of the stripping matrix element enhances the peripheral part of the amplitude although the internal contribution doesn't disappear and increases with increase of the deuteron energy. We present calculations corroborating our findings for both stripping to the bound state and the resonance.
description: 54 pages, 12 figures, accepted for publication in the Physical Review C
A role for the elongator complex in zygotic paternal genome demethylation
Creators: name: Okada, Yuki
name: Zhang, Yi
name: Yamagata, Kazuo
name: Wakayama, Teruhiko
name: Hong, Kwonho
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The life cycle of mammals begins when a sperm enters an egg. Immediately after fertilization, both the maternal and paternal genomes undergo dramatic reprogramming to prepare for the transition from germ cell to somatic cell transcription programs 1. One of the molecular events that takes place during this transition is the demethylation of the paternal genome 2,3. Despite extensive efforts, the factors responsible for paternal DNA demethylation have not been identified 4. To search for such factors, we developed a live cell imaging system that allows us to monitor the paternal DNA methylation state in zygotes. Through siRNA-mediated knockdown in zygotes, we identified Elp3/KAT9, a component of the elongator complex 5, to be important for paternal DNA demethylation. We demonstrate that knockdown of Elp3 impairs paternal DNA demethylation as indicated by reporter binding, immunostaining and bisulfite sequencing. Similar results were also obtained when other elongator components, Elp1 and Elp4, were knocked down. Importantly, injection of mRNA encoding the Elp3 radical SAM domain mutant, but not the HAT domain mutant, into MII oocytes before fertilization also impaired paternal DNA demethylation indicating that the SAM radical domain is involved in the demethylation process. Thus, our study not only establishes a critical role for the elongator in zygotic paternal genome demethylation, but also suggests that the demethylation process may be mediated through a reaction that requires an intact radical SAM domain.
Functorial destackification of tame stacks with abelian stabilisers
Creators: name: Bergh, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14A20, 14E15

description: We give an algorithm for removing stackiness from smooth, tame Artin stacks with abelian stabilisers by repeatedly applying stacky blow-ups. The construction works over a general base and is functorial with respect to base change and compositions with gerbes and smooth, stabiliser preserving maps. As applications, we indicate how the result can be used for destackifying general Deligne-Mumford stacks in characteristic zero, and to obtain a weak factorisation theorem for such stacks. Over an arbitrary field, the method can be used to obtain a functorial algorithm for desingularising varieties with simplicial toric quotient singularities, without assuming the presence of a toroidal structure.
Additional file 4 of Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review
Creators: name: Wenning, Brianne
name: Price, Helen
name: Nuwangi, Hasara
name: Reda, Kelemework Tafere
name: Walters, Ben
name: Ehsanullah, Reem
name: Viana, Greice
name: Andras, Alina
name: Dikomitis, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Search strategy for EMBASE.
Disentangling phase transitions and critical points in the proton-neutron interacting boson model by catastrophe theory
Creators: name: Garcia-Ramos, J. E.
name: Arias, J. M.
name: Dukelsky, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We introduce the basic concepts of catastrophe theory needed to derive analytically the phase diagram of the proton-neutron interacting boson model (IBM-2). Previous studies [1,2,3] were based on numerical solutions. We here explain the whole IBM-2 phase diagram including the precise order of the phase transitions in terms of the cusp catastrophe.
description: To be published in Physics Letters B
Photoionization cross section of 1s orthoexcitons in cuprous oxide
Creators: name: Frazer, Laszlo
name: Chang, Kelvin B.
name: Poeppelmeier, Kenneth R.
name: Ketterson, John B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report measurements of the attenuation of a beam of orthoexciton-polaritons by a photoionizing optical probe. Excitons were prepared in a narrow resonance by two photon absorption of a 1.016 eV, 54 ps pulsed light source in cuprous oxide (Cu2O) at 1.4 K. A collinear, 1.165 eV, 54 ps probe delayed by 119 ps was used to measure the photoionization cross section of the excitons. Two photon absorption is quadratic with respect to the intensity of the pump and leads to polariton formation. Ionization is linear with respect to the intensity of the probe. Subsequent carrier recombination is quadratic with respect to the intenisty of the probe, and is distinguished because it shifts the exciton momentum away from the polariton anticrossing; the photoionizing probe leads to a rise in phonon-linked luminescence in addition to the attenuation of polaritons. The evolution of the exciton density was determined by variably delaying the probe pulse. Using the probe irradiance and the reduction in the transmitted polariton light, a cross section of 3.9*10^(-22) m^2 was deduced for the probe frequency.
Biological, clinical and population relevance of 95 loci for blood lipids
Creators: name: Johnson, Toby
name: Stylianou, Ioannis M.
name: Chasman, Daniel I.
name: Jin Go, Min
name: Ricketts, Sally L.
name: Lee, Jong-Young
name: Willer, Cristen J.
name: Pirruccello, James P.
name: Koseki, Masahiro
name: Barbalic, Maja
name: Li, Mingyao
name: Edmondson, Andrew C.
name: Johansen, Christopher T.
name: Musunuru, Kiran
name: Li, Xiaohui
name: Orho-Melander, Marju
name: Smith, Albert V.
name: Peloso, Gina M.
name: Guo, Xiuqing
name: Teslovich, Tanya M.
name: Shin Cho, Yoon
name: Feitosa, Mary F.
name: Jin Kim, Young
name: Isaacs, Aaron
name: Park, Taesung
name: Thorleifsson, Gudmar
name: Bis, Joshua C.
name: Melander, Olle
name: Ripatti, Samuli
name: Aulchenko, Yurii S.
name: Chambers, John
name: Fouchier, Sigrid W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Serum concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with serum lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 × 10-8), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (e.g., CYP7A1, NPC1L1, and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and impact lipid traits in three non-European populations (East Asians, South Asians, and African Americans). Our results identify several novel loci associated with serum lipids that are also associated with CAD. Finally, we validated three of the novel genes—GALNT2, PPP1R3B, and TTC39B—with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
A Novel Hybrid Crossover based Artificial Bee Colony Algorithm for Optimization Problem
Creators: name: Kumar, Sandeep
name: Sharma, Vivek Kumar
name: Kumari, Rajani
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Artificial bee colony (ABC) algorithm has proved its importance in solving a number of problems including engineering optimization problems. ABC algorithm is one of the most popular and youngest member of the family of population based nature inspired meta-heuristic swarm intelligence method. ABC has been proved its superiority over some other Nature Inspired Algorithms (NIA) when applied for both benchmark functions and real world problems. The performance of search process of ABC depends on a random value which tries to balance exploration and exploitation phase. In order to increase the performance it is required to balance the exploration of search space and exploitation of optimal solution of the ABC. This paper outlines a new hybrid of ABC algorithm with Genetic Algorithm. The proposed method integrates crossover operation from Genetic Algorithm (GA) with original ABC algorithm. The proposed method is named as Crossover based ABC (CbABC). The CbABC strengthens the exploitation phase of ABC as crossover enhances exploration of search space. The CbABC tested over four standard benchmark functions and a popular continuous optimization problem.
Sgabuzzini storici [poster]
Sgabuzzini storici [poster]
Creators: name: Bacchitta, Sandra
Publisher: name: S. Bacchitta, "Sgabuzzini storici", in Metti la storia al lavoro! Seconda conferenza italiana di Public History. Pisa, 11-15 giugno 2018
Year: 2019

description: Sgabuzzini Storici è un’associazione culturale che dal 2011 si occupa di conservazione e divulgazione della memoria e della conoscenza storica e di valorizzazione del territorio e del patrimonio culturale. Il nostro territorio di riferimento è il Chianti e la nostra sede si trova a San Casciano in Val di Pesa.
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase
Creators: name: Li, Jiang
name: Wang, Lijuan
name: Liu, Zheyun
name: Tan, Chuang
name: Guo, Xunmin
name: Sancar, Aziz
name: Zhong, Dongping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: One of the detrimental effects of UV radiation on DNA is the formation of the (6-4) photoproduct (6-4PP) between two adjacent pyrimidines1. This lesion interferes with replication and transcription and may result in mutation and cell death2. In many organisms a flavoenzyme called photolyase uses blue light energy to repair the 6-4PP3. The molecular mechanism of the repair reaction is poorly understood. Here, we use ultrafast spectroscopy to show that the key step in the repair photocycle is a cyclic proton transfer between the enzyme and the substrate. By femtosecond synchronization of the enzymatic dynamics with the repair function, we followed the function evolution and observed direct electron transfer from the excited flavin cofactor to the 6-4PP in 225 ps but surprisingly fast back electron transfer in 50 ps without repair. Strikingly, we found that the catalytic proton transfer between a histidine residue in the active site and the 6-4PP, induced by the initial photoinduced electron transfer from the excited flavin cofactor to 6-4PP, occurs in 425 ps and leads to 6-4PP repair in tens of nanoseconds. These key dynamics define the repair photocycle and explain the underlying molecular mechanism of the enzyme’s modest efficiency.
Additional file 5 of Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review
Creators: name: Wenning, Brianne
name: Price, Helen
name: Nuwangi, Hasara
name: Reda, Kelemework Tafere
name: Walters, Ben
name: Ehsanullah, Reem
name: Viana, Greice
name: Andras, Alina
name: Dikomitis, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5. Search strategy for MEDLINE.
A Viable model for modified gravity
Creators: name: Granda, L. N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose a model for modified gravity that meets the conditions of viability. The model has stable constant curvature solution and for an special case contains flat space time solution. The model also leads to matter stability under small perturbations of scalar curvature. We give an example of restrictions on the parameters that give large enough scalaron mass to avoid detectable corrections to the Newton's law. The model describes inflation and late time accelerated expansion with an effective cosmological constant for the inflationary epoch and small effective cosmological constant for the current accelerated phase.
description: 17 pages
Heterogeneity of cyanobacterial gas-vesicle volume and metabolic activity
Creators: name: Brookes, Justin D
name: Ganf, George G
name: Oliver, Roderick L
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The literature suggests that relative gas-vesicle volume and metabolic activity differ between individuals within natural populations of cyanobacteria. We demonstrate, using flow cytometry and fluorescein diacetate (FDA) conversion rates, that individual relative gas-vesicle volumes differed by 6.7- and 4.6-fold, and individual cell photosynthetic rates ranged from 0.026 to 0.127 and from 0.075 to 2.415 fmol O2 cell–1 min–1 within phosphorus-starved and phosphorus-replete Microcystis aeruginosa populations, respectively. The observation that there is considerable heterogeneity in gas-vesicle volume and cell metabolic activity in cultured populations suggests that this could also contribute to heterogeneity in buoyancy of field populations.
การเปรียบเทียบความคิดเห็นต่อการบริหารจัดการและผลการดำเนินงานของวารสารวิชาการในประเทศไทย
Creators: name: ณัฐธกานต์ จันดาโชติ
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยกาฬสินธุ์
Year: 2023
Subjects: การบริหารจัดการ
ผลการดำเนินงาน
วารสารวิชาการในประเทศไทย

description: วารสารมนุษยศาสตร์ สังคมศาสตร์ และนวัตกรรม มหาวิทยาลัยกาฬสินธุ์, 2, 1, 36-50
Internal parity symmetry and degeneracy of Bethe Ansatz strings in the isotropic heptagonal magnetic ring
Creators: name: Milewski, Jan
name: Lulek, Barbara
name: Lulek, Tadeusz
name: Labuz, Miroslaw
name: Stagraczynski, Ryszard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The exact Bethe eigenfunctions for the heptagonal ring within the isotropic XXX model exhibit a doubly degenerated energy level in the three-deviation sector at the centre of the Brillouin zone. We demonstrate an explicit construction of these eigenfunctions by use of algebraic Bethe Ansatz, and point out a relation of degeneracy to parity conservation, applied to the configuration of strings for these eigenfunctions. Namely, the internal structure of the eigenfunctions (the 2-string and the 1-string, with opposite quasimomenta) admits generation of two mutually orthogonal eigenfunctions due to the fact that the strings which differ by their length are distinguishable objects.
Functional impact of global rare copy number variation in autism spectrum disorders
Creators: name: Berney, Tom
name: Corsello, Christina
name: Bolton, Patrick F.
name: Pinto, Dalila
name: Brennan, Sean
name: Chung, Brian H.Y.
name: Conroy, Judith
name: Merico, Daniele
name: Battaglia, Agatino
name: Casey, Jillian
name: Klei, Lambertus
name: Bourgeron, Thomas
name: Bölte, Sven
name: Magalhaes, Tiago R.
name: Bader, Gary D.
name: Bailey, Anthony J.
name: Crawford, Emily L.
name: Almeida, Joana
name: Anney, Richard
name: Crossett, Andrew
name: Regan, Regina
name: Bryson, Susan E.
name: Casallo, Guillermo
name: Correia, Catarina
name: Bolshakova, Nadia
name: Cochrane, Lynne
name: Baird, Gillian
name: Brian, Jessica
name: Pagnamenta, Alistair T.
name: Carson, Andrew R.
name: Bacchelli, Elena
name: Abrahams, Brett S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviors1. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability (ID)2. While ASDs are known to be highly heritable (~90%)3, the underlying genetic determinants are still largely unknown. Here, we analyzed the genome-wide characteristics of rare (<1% frequency) copy number variation (CNV) in ASD using dense genotyping arrays. When comparing 996 ASD individuals of European ancestry to 1,287 matched controls, cases were found to carry a higher global burden of rare, genic CNVs (1.19 fold, P= 0.012), especially so for loci previously implicated in either ASD and/or intellectual disability (1.69 fold, P= 3.4×10−4). Among the CNVs, there were numerous de novo and inherited events, sometimes in combination in a given family, implicating many novel ASD genes like SHANK2, SYNGAP1, DLGAP2 and the X-linked DDX53-PTCHD1 locus. We also discovered an enrichment of CNVs disrupting functional gene-sets involved in cellular proliferation, projection and motility, and GTPase/Ras signaling. Our results reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
Local Optimal Sets and Bounded Archiving on Multi-objective NK-Landscapes with Correlated Objectives
Creators: name: López-Ibáñez, Manuel
name: Liefooghe, Arnaud
name: Verel, Sébastien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The properties of local optimal solutions in multi-objective combinatorial optimization problems are crucial for the effectiveness of local search algorithms, particularly when these algorithms are based on Pareto dominance. Such local search algorithms typically return a set of mutually nondominated Pareto local optimal (PLO) solutions, that is, a PLO-set. This paper investigates two aspects of PLO-sets by means of experiments with Pareto local search (PLS). First, we examine the impact of several problem characteristics on the properties of PLO-sets for multi-objective NK-landscapes with correlated objectives. In particular, we report that either increasing the number of objectives or decreasing the correlation between objectives leads to an exponential increment on the size of PLO-sets, whereas the variable correlation has only a minor effect. Second, we study the running time and the quality reached when using bounding archiving methods to limit the size of the archive handled by PLS, and thus, the maximum size of the PLO-set found. We argue that there is a clear relationship between the running time of PLS and the difficulty of a problem instance.
description: appears in Parallel Problem Solving from Nature - PPSN XIII, Ljubljana : Slovenia (2014)
Additional file 6 of Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review
Creators: name: Wenning, Brianne
name: Price, Helen
name: Nuwangi, Hasara
name: Reda, Kelemework Tafere
name: Walters, Ben
name: Ehsanullah, Reem
name: Viana, Greice
name: Andras, Alina
name: Dikomitis, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 6. Search strategy for OVID.
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Creators: name: McLellan, Michael D.
name: Ellis, Matthew J.
name: Tao, Yu
name: Lin, Li
name: Vickery, Tammi L.
name: Fulton, Lucinda L.
name: Lin, Ling
name: Koboldt, Daniel C.
name: Appelbaum, Elizabeth
name: DeSchryver, Katherine
name: Zhang, Qunyuan
name: Schmidt, Heather
name: Ding, Li
name: Wallis, John W.
name: Crowder, Robert
name: Kalicki, Joelle
name: Larson, David E.
name: McMichael, Joshua F.
name: Fulton, Robert S.
name: Hoog, Jeremy
name: Li, Shunqiang
name: Chen, Ken
name: Cook, Lisa
name: Magrini, Vincent J.
name: Chen, Lei
name: Davies, Sherri
name: Wendl, Michael C.
name: Abbott, Rachel M.
name: Guintoli, Therese
name: McGrath, Sean D.
name: Harris, Christopher C.
name: Dooling, David J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumor progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer: peripheral blood, the primary tumor, a brain metastasis, and a xenograft derived from the primary tumor. The metastasis contained two de novo mutations and a large deletion not present in the primary tumor, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumor mutations, and displayed a mutation enrichment pattern that paralleled the metastasis (16 of 20 genes). Two overlapping large deletions, encompassing CTNNA1, were present in all three tumor samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared to the primary tumor suggest that secondary tumors may arise from a minority of cells within the primary.
The NASA-UC-UH Eta-Earth Program: IV. A Low-mass Planet Orbiting an M Dwarf 3.6 PC from Earth
Creators: name: Howard, Andrew W.
name: Marcy, Geoffrey W.
name: Fischer, Debra A.
name: Isaacson, Howard
name: Muirhead, Philip S.
name: Henry, Gregory W.
name: Boyajian, Tabetha S.
name: von Braun, Kaspar
name: Becker, Juliette C.
name: Wright, Jason T.
name: Johnson, John Asher
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the discovery of a low-mass planet orbiting Gl 15 A based on radial velocities from the Eta-Earth Survey using HIRES at Keck Observatory. Gl 15 Ab is a planet with minimum mass Msini = 5.35 $\pm$ 0.75 M$_\oplus$, orbital period P = 11.4433 $\pm$ 0.0016 days, and an orbit that is consistent with circular. We characterize the host star using a variety of techniques. Photometric observations at Fairborn Observatory show no evidence for rotational modulation of spots at the orbital period to a limit of ~0.1 mmag, thus supporting the existence of the planet. We detect a second RV signal with a period of 44 days that we attribute to rotational modulation of stellar surface features, as confirmed by optical photometry and the Ca II H & K activity indicator. Using infrared spectroscopy from Palomar-TripleSpec, we measure an M2 V spectral type and a sub-solar metallicity ([M/H] = -0.22, [Fe/H] = -0.32). We measure a stellar radius of 0.3863 $\pm$ 0.0021 R$_\odot$ based on interferometry from CHARA.
description: ApJ accepted, 11 pages, 8 figures, 3 tables
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Creators: name: Pastinen, Tomi
name: Raychaudhuri, Soumya
name: Heard-Costa, Nancy L.
name: Lango Allen, Hana
name: Yang, Jian
name: Heid, Iris M.
name: Park, Ju-Hyun
name: Jackson, Anne U.
name: Speliotes, Elizabeth K.
name: Wood, Andrew R.
name: Winkler, Thomas W.
name: Goddard, Michael E.
name: Estrada, Karol
name: Berndt, Sonja I.
name: Willer, Cristen J.
name: Soranzo, Nicole
name: Gudbjartsson, Daniel
name: Qi, Lu
name: Mägi, Reedik
name: Ferreira, Teresa
name: Wheeler, Eleanor
name: Vernon Smith, Albert
name: Weyant, Robert J.
name: Thorleifsson, Gudmar
name: Luan, Jian’an
name: Lettre, Guillaume
name: Rivadeneira, Fernando
name: Vedantam, Sailaja
name: Randall, Joshua C.
name: Weedon, Michael N.
name: Liang, Liming
name: Segrè, Ayellet V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence phenotype. Genome-wide association (GWA) studies have identified >600 variants associated with human traits1, but these typically explain small fractions of phenotypic variation, raising questions about the utility of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait2,3. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P=0.016), and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants, and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented amongst variants that alter amino acid structure of proteins and expression levels of nearby genes. Our data explain ∼10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to ∼16% of phenotypic variation (∼20% of heritable variation). Although additional approaches are needed to fully dissect the genetic architecture of polygenic human traits, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
Capillary surfaces in a cone
Creators: name: López, Rafael
name: Pyo, Juncheol
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A10, 49Q10, 76B45, 76D45

description: We show that a capillary surface in a solid cone, that is, a surface that has constant mean curvature and the boundary of surface meets the boundary of the cone with a constant angle, is radially graphical if the mean curvature is non-positive with respect to the Gauss map pointing toward the domain bounded by the surface and the boundary of the cone. In the particular case that the cone is circular, we prove that the surface is a spherical cap or a planar disc. The proofs are based on an extension of the Alexandrov reflection method by using inversions about spheres.
McMillan-Mayer Theory of Solutions Revisited: Simplifications and Extensions
Creators: name: Vafaei, Shaghayegh
name: Tomberli, Bruno
name: Gray, C. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: McMillan and Mayer (MM) proved two remarkable theorems in their paper on the equilibrium statistical mechanics of liquid solutions. They first showed that the grand canonical partition function for a solution can be reduced to a one with an effectively solute-only form, by integrating out the solvent degrees of freedom. The total effective solute potential in the effective solute grand partition function can be decomposed into components which are potentials of mean force for isolated groups of one, two, three, etc, solute molecules. Secondly, from the first result, now assuming low solute concentration, MM derived an expansion for the osmotic pressure in powers of the solute concentration, in complete analogy with the virial expansion of gas pressure in powers of the density at low density. The molecular expressions found for the osmotic virial coefficients have exactly the same form as the corresponding gas virial coefficients, with potentials of mean force replacing vacuum potentials. In this paper we restrict ourselves to binary liquid solutions with solute species $A$ and solvent species $B$ and do three things: (a) By working with a semi-grand canonical ensemble (grand with respect to solvent only) instead of the grand canonical ensemble used by MM, and avoiding graphical methods, we have greatly simplified the derivation of the first MM result,(b) by using a simple nongraphical method developed by van Kampen for gases, we have greatly simplified the derivation of the second MM result,i.e.,the osmotic pressure virial expansion; as a by-product, we show the precise relation between MM theory and Widom potential distribution theory, and (c) we have extended MM theory by deriving virial expansions for other solution properties such as the enthalpy of mixing. The latter expansion, with changed independent variables corresponding to current experiments, is proving useful.
description: pdftex, 32 pages, 2 figures. Thermodynamic errata in Section IV.C and Appendix B are corrected. Figure 2 is recalculated at a new temperature to correspond with more recent experimental data
Non-geometric orbifolds and wrapping rules
Creators: name: Pradisi, Gianfranco
name: Riccioni, Fabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that the number of half-supersymmetric p-branes in the Type II theories compactified on orbifolds is determined by the wrapping rules recently introduced, provided that one accounts correctly for both geometric and non-geometric T-dual configurations. Starting from the Type II theories compactified on K3, we analyze their toroidal dimensional reductions, showing how the resulting half-supersymmetric p-branes satisfy the wrapping rules only by taking into account all the possible higher-dimensional origins. We then consider Type II theories compactified on the orbifold T^6/(Z_2 \times Z_2 ), whose massless four-dimensional theory is an N=2 supergravity. Again, the wrapping rules are obeyed only if one includes the complete orbit of the T-duality group, namely either Type IIA or Type IIB theories compactified on either the geometric or the non-geometric T-dual orbifold. Finally, we comment on the interpretation of our results in the framework of the duality between the Heterotic string compactified on K3 \times T^2 and the Type II string compactified on a Calabi-Yau threefold.
description: 26 pages, 8 tables
International network of cancer genome projects
Creators: name: Laplace, Frank
name: Calvo, Fabien
name: Bernabé, Rosa R.
name: Nettekoven, Gerd
name: Schafer, Alan J.
name: Bell, Cindy
name: Remacle, Jacques
name: Yang, Huanming
name: Jennings, Jennifer L.
name: Rao, T.S.
name: Guyer, Mark
name: Kerr, David
name: Kusuda, Jun
name: Guttmacher, Alan
name: Stratton, Michael R.
name: Hemsley, Fiona M.
name: Barker, Anna D.
name: Klatt, Peter
name: Aretz, Axel
name: Kolar, Patrik
name: Shibata, Tatsuhiro
name: Hudson (Chairperson), Thomas J.
name: Lane, David P.
name: Ozenberger, Brad
name: Eerola, Iiro
name: Vockley, Joseph G.
name: Anderson, Warwick
name: Bhan, M. K.
name: Lu, Youyong
name: Gerhard, Daniela S.
name: Watanabe, Koichi
name: Peterson, Jane
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically-relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
Additional file 7 of Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review
Creators: name: Wenning, Brianne
name: Price, Helen
name: Nuwangi, Hasara
name: Reda, Kelemework Tafere
name: Walters, Ben
name: Ehsanullah, Reem
name: Viana, Greice
name: Andras, Alina
name: Dikomitis, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 7. Search strategy for Psych Info.
Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends
Creators: name: Hasty, Paul
name: Ramsden, Dale A.
name: Burkhalter, Martin D.
name: Strande, Natasha
name: Roberts, Steven A.
name: Havener, Jody M.
name: Strom, Christina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Mammalian cells require Nonhomologous end joining (NHEJ) for efficient repair of chromosomal DNA double-strand breaks1. A key feature of biological sources of strand breaks is associated nucleotide damage, including base loss (abasic or AP sites)2. At single strand breaks, 5' terminal abasic sites are excised by pol β's 5'dRP lyase activity3,4,5,6: we show here in vitro and in cells that accurate and efficient repair by NHEJ of double-strand breaks with such damage similarly requires 5'dRP/AP lyase activity (Figure 1a). Classically defined NHEJ is moreover uniquely effective at coupling this end-cleaning step to joining in cells, helping distinguish this pathway from otherwise robust alternate NHEJ pathways. Surprisingly, the NHEJ factor Ku can be identified as an effective 5'dRP/AP lyase. Similar to other lyases7, Ku nicks DNA 3' of an abasic site by a mechanism involving a Schiff base covalent intermediate with the abasic site. We demonstrate using cell extracts that Ku is essential for efficient removal of AP sites near double-strand breaks and, consistent with this result, joining of such breaks is specifically reduced in cells complemented with a lyase-attenuated Ku mutant. Ku had previously been presumed only to recognize ends and recruit other factors that processed ends; our data supports an unexpected direct role for Ku in end processing steps as well.
Central exclusive production at RHIC
Creators: name: Adamczyk, L.
name: Guryn, W.
name: Turnau, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The present status and and future plans of the physics program of Central Exclusive Production at RHIC are described.
description: 9 pages, 5 figures, to appear as a review article in IJMPA
Mobiline peritrich riders on Australian calanoid copepods
Creators: name: Green, John D
name: Shiel, Russell J
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Calanoid copepods from billabongs near Wodonga, Victoria, Australia were found to be infested with a disc-shaped mobiline peritrich ciliate belonging to the genus Trichodina. Biometrical data, including mean body diameter (43.6 m), mean adhesive disc diameter (35.9 m), mean denticle ring diameter (20.1 m), modal denticle number (17), modal number of radial pins per denticle (9), and denticle shape and dimensions, indicate that the species is T. diaptomi Basson & Van As (1991). This is the first record of T. diaptomi from Australasia. Adults of Boeckella fluvialis and B. minuta were infected, but adult Calamoecia lucasi were not. Levels of infestation were higher on B. fluvialis (67.5% of females, 54.5% of males) than B. minuta (47.4% of females, 33.3% of males). Mean numbers of Trichodina per adult B. fluvialis were 7.68 (range 0–78) for females and 4.06 (range 0–43) for males, and differed significantly between sexes. Although calanoid copepods were present in the plankton from January to early December 1991, Trichodina infestations occurred during October and November only, peaking during late November just before the copepods disappeared from the plankton. Whether the infestation was a cause of the copepod decline, developed because the copepods were rendered susceptible to infection by some other cause, or was determined by physical and/or chemical environmental factors is unknown.