cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Tension Amplification in Molecular Brushes in Solutions and on Substrates †
Creators: name: Brock, James
name: Rubinstein, Michael
name: Sheiko, Sergei S.
name: Panyukov, Sergey
name: Zhulina, Ekaterina B.
name: Randall, Greg C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Molecular bottle-brushes are highly branched macromolecules with side chains densely grafted to a long polymer backbone. The brush-like architecture allows focusing of the side-chain tension to the backbone and its amplification from the picoNewton to nanoNewton range. The backbone tension depends on the overall molecular conformation and the surrounding environment. Here we study the relation between the tension and conformation of the molecular brushes in solutions, melts, and on substrates. In solutions, we find that the backbone tension in dense brushes with side chains attached to every backbone monomer is on the order of f0N3/8 in athermal solvents, f0N1/3 in θ-solvents, and f0 in poor solvents and melts, where N is the degree of polymerization of side chains, f0≃ kBT/b is the maximum tension in side chains, b is the Kuhn length, kB is Boltzmann constant, and T is absolute temperature. Depending on the side chain length and solvent quality, molecular brushes in solutions develop tension on the order of 10–100 picoNewtons, which is sufficient to break hydrogen bonds. Significant amplification of tension occurs upon adsorption of brushes onto a substrate. On a strongly attractive substrate, maximum tension in the brush backbone is ~ f0N, reaching values on the order of several nanoNewtons which exceed the strength of a typical covalent bond. At low grafting density and high spreading parameter the cross-sectional profile of adsorbed molecular brush is approximately rectangular with thicknes ~bA/S, where A is the Hamaker constant and S is the spreading parameter. At a very high spreading parameter (S > A), the brush thickness saturates at monolayer ~ b. At a low spreading parameter, the cross-sectional profile of adsorbed molecular brush has triangular tent-like shape. In the cross-over between these two opposite cases, covering a wide range of parameter space, the adsorbed molecular brush consists of two layers. Side chains in the lower layer gain surface energy due to the direct interaction with the substrate, while the second layer spreads on the top of the first layer. Scaling theory predicts that this second layer has a triangular cross-section with width R ~ N3/5 and height h ~ N2/5. Using self-consistent field theory we calculate the cap profile y (x) = h (1 − x2/R2)2, where x is the transverse distance from the backbone. The predicted cap shape is in excellent agreement with both computer simulation and experiment.
title: Früh auf - dann ins Museum
Creators: name: Benkö, Edith Ingeborg
Year: 2021

description: Im Zentrum dieser Arbeit steht der Musealbeamte und Geologe Franz Heger als Schlüsselfigur im naturkundlichen Sammlungs- und Museumsbetrieb Wiens. Heger, er war als Autodidakt auch auf den Gebieten der Prähistorie und Ethnologie tätig, unternahm in der zweiten Hälfte des 19. Jahrhunderts sieben Reisen ins russländische Reich. Diese Reisen und sein Netzwerk zu russländischen Prähistoriker*innen und Archäolog*innen sollen im Spiegel seiner Schriften, Reiseberichte und Manuskripte analysiert und anhand seiner Arbeit als Sekretär der Anthropologischen Gesellschaft in Wien, seiner Wissenschaftskontakte und der Teilnahme an den Allrussischen Archäologenkongressen mit Methoden der Netzwerktheorie dargestellt werden. Die erkenntnisleitenden Interessen dieser Arbeit bilden Fragen nach den Intentionen der Reisen zwischen 1881 und 1893, nach den besuchten Orten und Institutionen und dem Netzwerk zu russländischen Wissenschaftler*innen und Wissenschaftsinstitutionen. Die Analyse der wissenschaftlichen Notizbücher und Manuskripte aus dem Archiv des Weltmuseum Wien zeigt Sammlungsankäufe für das damalige k.k. naturhistorische Hofmuseum, wissenschaftliche Publikationen für die Anthropologische Gesellschaft in Wien und Reiseberichte für ein breiteres bürgerliches Publikum als Transferleistungen und kontextualisiert den unermüdlichen reisenden Beamten als Teil eines, im Sinne kolonialer Aneignung funktionierenden Wissenschaftsbetriebes.
description: This thesis deals with the museal official and geologist Franz Heger as a key figure within the natural history museum and collecting landscape in Vienna in the 19th century Vienna. In the 1880s Heger, who worked as an autodidact in the field of prehistory and ethnology as well, went on seven journeys to the Russian Empire. Using methods of network theory these journeys and Hegers contacts to Russian prehistorians and archeologists shall be analysed in reflection of his scripts, travelogues and manuscripts and illustrated by means of his work as the secretary of the Anthropological Society of Vienna, his academic connections and the participation in the Russian Archeological Congresses. The underlying questions of this thesis ask for the intentions of his travels between 1881 and1893, the places and institutions he visited and his network to Russian scientists and scientific institutions. The analysis outlines Hegers purchase of collections for the former „k. k. Naturhistorisches Hofmuseum“, his scientific essays for the Anthropological Society of Vienna and the travelogues in Viennese newspapers for a broad civil audience as an act of transfer of knowledge. Furthermore it reveals the indefatigable travelling official as a part of the academic community in the context of colonial appropriation.
Translational and Rotational Diffusion of a Small Globular Protein under Crowded Conditions
Creators: name: Pielak, Gary J.
name: Wang, Yaqiang
name: Li, Conggang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Protein protein interaction is the fundamental step of biological signal transduction. Interacting proteins find each other by diffusion. To gain insight into diffusion under the crowded conditions found in cells, we used nuclear magnetic resonance spectroscopy (NMR) to measure the effects of solvent additives on the translational and rotational diffusion of the 7.4 kDa globular protein, chymotrypsin inhibitor 2. The additives were glycerol and the macromolecular crowding agent, polyvinylpyrrolidone (PVP). Both translational diffusion and rotational diffusion decrease with increasing solution viscosity. For glycerol, the decrease obeys the Stokes Einstein and Stokes Einstein Debye laws. Three types of deviation are observed for PVP: the decrease in diffusion with increased viscosity is less than predicted, this negative deviation is greater for rotational diffusion, and the negative deviation increases with increasing PVP molecular weight. We discuss our results in terms of other studies on the effects of macromolecules on globular protein diffusion.
(Uniform) Convergence of Twisted Ergodic Averages
Creators: name: Eisner, Tanja
name: Krause, Ben
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: Classical Analysis and ODEs (math.CA)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $T$ be an ergodic measure-preserving transformation on a non-atomic probability space $(X,Σ,μ)$. We prove uniform extensions of the Wiener-Wintner theorem in two settings: For averages involving weights coming from Hardy field functions, $p$: \[ \{\frac{1}{N} \sum_{n\leq N} e(p(n)) T^{n}f(x) \} \] and for "twisted" polynomial ergodic averages: \[ \{\frac{1}{N} \sum_{n\leq N} e(n θ) T^{P(n)}f(x) \} \] for certain classes of badly approximable $θ\in [0,1]$. We also give an elementary proof that the above twisted polynomial averages converge pointwise $μ$-a.e. for $f \in L^p(X), \ p >1,$ and arbitrary $θ\in [0,1]$.
description: 31 pages, the referee's suggestions incorporated, references added, typos corrected. A uniform estimate of the ergodic averages with Hardy field weights by the corresponding Gowers-Host-Kra uniformity seminorms is added, see Theorem 2.11. To appear in Ergodic Theory Dynam. Systems
Maximum population transfer in a periodically driven two-level system
Creators: name: Poggi, P. M.
name: Arranz, F. J.
name: Benito, R. M.
name: Borondo, F.
name: Wisniacki, D. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the dynamics of a two-level quantum system under the influence of sinusoidal driving in the intermediate frequency regime. Analyzing the Floquet quasienergy spectrum, we find combinations of the field parameters for which population transfer is optimal and takes place through a series of well defined steps of fixed duration. We also show how the corresponding evolution operator can be approximated at all times by a very simple analytical expression. We propose this model as being specially suitable for treating periodic driving at avoided crossings found in complex multi-level systems, and thus show a relevant application of our results to designing a control protocol in a realistic molecular model
description: 7 pages, 6 figures
Basic Forms and Orbit Spaces: a Diffeological Approach
Creators: name: Karshon, Yael
name: Watts, Jordan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 58D19, 57R99

description: If a Lie group acts on a manifold freely and properly, pulling back by the quotient map gives an isomorphism between the differential forms on the quotient manifold and the basic differential forms upstairs. We show that this result remains true for actions that are not necessarily free nor proper, as long as the identity component acts properly, where on the quotient space we take differential forms in the diffeological sense.
Thermal Hall Effect of Spins in a Paramagnet
Creators: name: Lee, Hyunyong
name: Han, Jung Hoon
name: Lee, Patrick A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Theory of Hall transport of spins in a correlated paramagnetic phase is developed. By identifying the thermal Hall current operator in the spin language, which turns out to equal the spin chirality in the pure Heisenberg model, various response functions can be derived straightforwardly. Subsequent reduction to the Schwinger boson representation of spins allows a convenient calculation of thermal and spin Hall coefficients in the paramagnetic regime using self-consistent mean-field theory. Com- parison is made to results from the Holstein-Primakoff reduction of spin operators appropriate for ordered phases.
Witnessing excellence in action: the ‘other-praising’ emotions of elevation, gratitude, and admiration
Creators: name: Haidt, Jonathan
name: Algoe, Sara B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: People are often profoundly moved by the virtue or skill of others, yet psychology has little to say about the ‘other-praising’ family of emotions. Here we demonstrate that emotions such as elevation, gratitude, and admiration differ from more commonly studied forms of positive affect (joy and amusement) in many ways, and from each other in a few ways. The results of studies using recall, video induction, event-contingent diary, and letter-writing methods to induce other-praising emotions suggest that: elevation (a response to moral excellence) motivates prosocial and affiliative behavior, gratitude motivates improved relationships with benefactors, and admiration motivates self-improvement. Mediation analyses highlight the role of conscious emotion between appraisals and motivations. Discussion focuses on implications for emotion research, interpersonal relationships, and morality.
Full multipartite entanglement of frequency comb Gaussian states
Creators: name: Gerke, S.
name: Sperling, J.
name: Vogel, W.
name: Cai, Y.
name: Roslund, J.
name: Treps, N.
name: Fabre, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: An analysis is conducted of the multipartite entanglement for Gaussian states generated by the parametric down-conversion of a femtosecond frequency comb. Using a recently introduced method for constructing optimal entanglement criteria, a family of tests is formulated for mode decompositions that extends beyond the traditional bipartition analyses. A numerical optimization over this family is performed to achieve maximal significance of entanglement verification. For experimentally prepared 4-, 6-, and 10-mode states, full entanglement is certified for all of the 14, 202, and 115974 possible nontrivial partitions, respectively.
description: close to published version, see also viewpoint http://physics.aps.org/articles/v8/10
Addressing Mental Health Challenges in Sierra Leone and the West African Sub region :A Path to Sustainable Development
Creators: name: Dumbuya, Emmanuel
Publisher: name: Zenodo
Year: 2025

description: This paper explores the state of mental health in Sierra Leone and the broader West African sub region, focusing on the challenges and barriers to mental health care in post-conflict societies. The study examines the social, economic, and political factors influencing mental health in Sierra Leone, particularly in the aftermath of the civil war and the Ebola epidemic. Using qualitative data from healthcare workers, policymakers, and individuals with lived experiences, the paper investigates the mental health system’s effectiveness and offers recommendations for improving access to mental health care. The paper further argues that mental health is a critical component of sustainable development in the region, with a need for greater investment in services, awareness, and mental health education.

Keywords: Mental health, Sierra Leone, West Africa, post-conflict recovery, healthcare, sustainable development, stigma, public health, social determinants, mental health care systems.
In search of durable positive psychology interventions: Predictors and consequences of long-term positive behavior change
Creators: name: Fredrickson, Barbara L.
name: Cohn, Michael A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A number of positive psychology interventions have successfully helped people learn skills for improving mood and building personal resources (e.g., psychological resilience and social support). However, little is known about whether intervention activities remain effective in the long term, or whether new resources are maintained after the intervention ends. We address these issues in a 15-month follow-up survey of participants from a loving-kindness meditation intervention. Many participants continued to practice meditation, and they reported more positive emotions (PEs) than those who had stopped meditating or had never meditated. All participants maintained gains in resources made during the initial intervention, whether or not they continued meditating. Continuing meditators did not differ on resources at baseline, but they did show more PE and a more rapid PE response to the intervention. Overall, our results suggest that positive psychology interventions are not just efficacious but of significant value in participants' real lives.
The Prevalence of Effective Substance Use Prevention Curricula in the Nation’s High Schools
Creators: name: Vincus, Amy A.
name: Rohrbach, Louise A.
name: Bowling, J. Michael
name: Ringwalt, Chris
name: Hanley, Sean
name: Ennett, Susan T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Despite a substantial proportion of high school students who initiate substance use following middle school, the implementation of universal evidence-based prevention curricula appears to be scant. We report data collected in 2005 from 1392 school-district based drug prevention coordinators, from a national, representative study of school-based substance use prevention practices. Altogether, 10.3% of districts that included high school grades reported administering one of six such curricula that were then rated as effective by the Substance Abuse and Mental Health Services Administration’s National Registry of Effective Programs and Practices or Blueprints for Violence Prevention, and 5.7% reported that they used one of these curricula the most. Only 56.5% of the nation’s districts with high school grades administered any substance use prevention programming in at least one of their constituent high schools.
Developing a Mathematical Model for Bobbin Lace
Creators: name: Irvine, Veronika
name: Ruskey, Frank
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: G.2.1; G.2.2; G.2.3

description: Bobbin lace is a fibre art form in which intricate and delicate patterns are created by braiding together many threads. An overview of how bobbin lace is made is presented and illustrated with a simple, traditional bookmark design. Research on the topology of textiles and braid theory form a base for the current work and is briefly summarized. We define a new mathematical model that supports the enumeration and generation of bobbin lace patterns using an intelligent combinatorial search. Results of this new approach are presented and, by comparison to existing bobbin lace patterns, it is demonstrated that this model reveals new patterns that have never been seen before. Finally, we apply our new patterns to an original bookmark design and propose future areas for exploration.
description: 20 pages, 18 figures, intended audience includes Artists as well as Computer Scientists and Mathematicians
Preventing and Treating Cancer through Genetic Testing, Research, and Pharmacogenetics: Ethical and Legal Challenges
Creators: name: Stasi, Elena
Publisher: name: Royal College of Surgeons in Ireland
Year: 2023
Subjects: subject: 220106 Medical Ethics
subject: FOS: Health sciences
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 111202 Cancer Diagnosis

description: Nowadays, cancer is one of the leading causes of death worldwide. Ongoing research proves the complexity of improving its prevention and treatment. The dissertation focuses on genetic testing, biomedical research, pharmacogenetics: how they are being implemented, how their potential can be ethically advanced and what legal challenges may arise. An in-depth literature review is conducted to analyse the technical, ethical and regulatory aspects around innovations for cancer prevention and treatment and intertwine them. Next generation sequencing technologies favour early diagnosis for some types of cancer, such as the BRCA positive ovarian and breast cancer. However, genetic testing gives rise to challenges related to incidental findings, storage of data in biobanks, gene patenting, privacy, and public health among others. Ethical and legal issues concerning biomedical research are discussed, with a focus on experimental care as well as questions on permissibility concerning cancer research conducted on animals, and the case of the Oncomouse. Breakthrough innovations in personalized medicine such as gene therapy are also considered from an ethical and legal point of view, with respect to global justice and human dignity. Inarguably, technology evolves at a faster pace than legislation; and the implementation of new therapies need to be done in an equitable way to ensure a just, safe and ethical advancement of care. The set of these elements around cancer prevention and treatment encompasses a shift in the relationship between healthcare practitioner and patient; a need for genetic counsellors; trustworthiness of the healthcare system and trust from patients in order to find an equilibrium between autonomy and paternalism to ensure optimal decision-making. To enforce quality standards in the development of novel solutions for cancer prevention and treatment in the clinical setting, appropriate legislation must accompany and protect the individual, society, and the human species.
Correlation between DNA bases and the intensity of the Raman bands with SERS
Creators: name: AZZIZ, Aicha
name: Qiqian LIU
name: MAJDINASAB, Marjan
name: KLÖS, Gunnar
name: CORTAJARENA, Aitziber LÓPEZ
name: EDELY, Mathieu
name: De La CHAPELLE, Marc LAMY
Publisher: name: Zenodo
Year: 2023
Subjects: SERS
DNA
Biosensor

description: Raman spectroscopy has become a popular tool for analyzing biological samples such as DNA. It allows us to access to the vibrational levels of molecules and thus to identify the chemical composition and to observe the structure of molecular systems.[1] In this work, we recorded the SERS spectra of DNA strands with different sequences and grafted at the surface of gold nanoparticles. Our objective is to study the correlation between the DNA sequences and its base composition and the intensity of Raman bands observed in SERS. To reach a high density of DNA on the surface of the gold nanoparticles, the DNA strands include a thiol group (SH) at their 5' end and are conjugated to gold nanoparticles using the freeze-thaw cycle method. SERS measurements are performed on dried drops deposited on a glass slide. We recorded 5 spectra for each sample using a 785nm excitation wavelength. We observed several bands that can be assigned to the different bases and to the phosphate backbone. For instance, the bands of ring breathing mode of adenine and the carbonic skeleton of the DNA are observable at 733cm-1 and 1029cm-1 respectively.[2] We then compare the relative intensity of the different bands such as the 733cm-1 or 1029cm-1 ones. We found that the relative intensity of the 733cm-1 band is correlated with the amount of adenine in the DNA sequence. This study provides a new approach for reliable quantification and analysis of genetic information associated with DNA molecule sequencing.
NPMC+ AS A MODEL SYSTEM TO INVESTIGATE THE ROLE OF QUIESCENCE IN LEUKEMIA DEVELOPMENT
Creators: name: BOGGIO MERLO, MARIA ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: The evolution of Acute Myeloid Leukemia (AML) is a complex process characterized by the stepwise accumulation of mutations, primarily occurring in Hematopoietic Stem Cells (HSCs). Such mutations give rise to the so-called Leukemia Initiating Cell (LIC), characterized by enhanced self-renewal and impaired differentiation. The molecular mechanisms underlying this transition are still poorly understood but they are likely to be critical to understanding the leukemic stem cell (LSC) biology. Recent functional and genetic studies on AML revealed NPMc+ as a critical driver oncogene, highly conserved at relapse, and characterizing the AML phenotype. Likely, NPMc+ has a pivotal role in the LIC evolution and LSC behavior. Taking advantage of the extended pre-leukemic phase of our inducible NPMc+ mouse model, we elucidated the impact of NPMc+ expression on normal HSCs to define the early mechanisms of NPMc+ induced leukemogenesis. We have found that NPMc+ expression leads to the expansion of the HSC compartment by enforcing a stem-cell transcriptional program that promotes quiescence and increases self-renewal. Moreover, considering the strong co-occurrence of NPMc+ with FLT3-ITD in patients, we investigated the mechanisms of this cooperation in pre-leukemia. Strikingly, the expression of NPMc+ in the FLT3-ITD background i) prevents the HSCs exhaustion imposed by FLT3-ITD, ii) restores their repopulating capacity, iii) restores the same transcriptional program observed in the NPMc+ HSCs, including quiescence genes upregulation. These data strongly suggest that NPMc+ and FLT3-ITD mutations cooperate in inducing AML, thanks to the NPMc+ ability to limit LT-HSCs exhaustion and reconstitute a fully competent LT-HSC population in which the oncogenic activities of FLT3-ITD lead to a rapid selection of the LICs. We thus hypothesized that enforced quiescence might be critical to maintain the transformed clone during both the pre-leukemic and the leukemic phase. In support, we xi identified the TGF? pathway, one of the most critical pathways that regulate HSCs quiescence, as being upregulated by NPMc+, either alone or in combination with FLT3- ITD. Moreover, we report that pharmacological inhibition of this pathway impacts on NPMc+/FLT3-ITD AML growth in vivo. Finally, we provide preliminary results suggesting that TGFb? inhibition might modify the fitness and/or the number of LSCs.
On the welded Tube map
Creators: name: Audoux, Benjamin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57Q45

description: This note investigates the so-called Tube map which connects welded knots, that is a quotient of the virtual knot theory, to ribbon torus-knots, that is a restricted notion of fillable knotted tori in the 4-sphere. It emphasizes the fact that ribbon torus-knots with a given filling are in one-to-one correspondence with welded knots before quotient under classical Reidemeister moves and reformulates these moves and the known sources of non-injectivity of the Tube map in terms of filling changes.
description: 23 pages ; v2: an error corrected and stylistic modifications ; to appear in Contemporary Mathematics
Use of HIV and HSV-2 Biomarkers in Sub-Saharan Adolescent Prevention Research: A Comparison of Two Approaches
Creators: name: Adze, Joel
name: Cho, Hyunsan
name: Luseno, Winnie K.
name: Rusakaniko, Simbarashe
name: Milimo, Benson
name: Iritani, Bonita J.
name: Hallfors, Denise Dion
name: Hobbs, Marcia
name: Mbai, Isabella
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Self-report of sexual behavior among adolescents is notoriously inconsistent, yet such measures are commonly used as outcomes for human immunodeficiency virus (HIV) prevention intervention trials. There has been a growing interest in the use of HIV and other sexually transmitted disease biomarkers as more valid measures of intervention impact in high HIV prevalence areas, particularly in sub-Saharan Africa. We examine the challenges, benefits, and feasibility of including HIV and herpes simplex virus type 2 (HSV-2) biomarker data, with details about different data collection and disclosure methods from two adolescent prevention trials in Kenya and Zimbabwe. In Kenya, whole blood samples were collected using venipuncture; adult guardians were present during biomarker procedures and test results were disclosed to participants and their guardians. In contrast, in Zimbabwe, samples were collected using finger pricks for dried blood spots (DBS); guardians were not present during biomarker procedures, and results were not disclosed to participants and/or their guardians. In both countries, prevalence in the study samples was low. Although the standard of care for testing for HIV and other sexually transmitted infections includes disclosure in the presence of a guardian for adolescents under age 18, we conclude that more research about the risks and benefits of disclosure to adolescents in the context of a clinical trial is needed. Notably, current serological diagnosis for HSV-2 has a low positive predictive value when prevalence is low, resulting in an unacceptable proportion of false positives and serious concerns about disclosing test results to adolescents within a trial. We also conclude that the DBS approach is more convenient and efficient than venipuncture for field research, although both approaches are feasible. Manufacturer validation studies using DBS for HSV-2, however, are needed for widespread use.
Addressing Psychosocial Adversity Within the Patient-Centered Medical Home: Expert-Created Measurable Standards
Creators: name: Bair-Merritt, Megan H.
name: Mandal, Mahua
name: Garg, Arvin
name: Cheng, Tina L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The Patient-Centered Medical Home (PCMH) may be improved by embedding identification and response for patients’ experiences with psychosocial adversity, but how this might optimally occur in practice has not been well-specified. We sought input from an expert panel to define feasible elements that could adapt the PCMH to adequately respond to patients’ experiences with psychosocial adversity. From December 2012 through September 2013, we used a Delphi process to systematically obtain expert opinions and reach consensus. We invited 37 experts to participate in three successive and iterative rounds of questionnaires, with each round based on aggregated, de-identified data from the prior round. We first asked experts to generate elements to adapt the PCMH, using the National Committee for Quality Assurance (NCQA’s) established six PCMH standards as the foundation. We then asked the experts to rate these elements on a 5-point Likert scale, and finally specify what they considered the most and least valuable elements. Eighteen of the 37 (49%) invited experts responded to the first survey, and constituted our sample. Experts identified 35 elements that fell under the six NCQA standards. The top rated elements included using a screening tool to identify adversity; training providers to address psychosocial adversity; having a team member with mental health expertise; providing culturally-competent care; and having written patient information related to adversity and coping. This study derived key elements that may enhance the PCMH’s ability to improve patient outcomes by purposefully identifying and responding to their psychosocial adversity.
Immediate placement of a porous-tantalum, trabecular metal-enhanced titanium dental implant with demineralized bone matrix into a socket with deficient buccal bone: A clinical report
Creators: name: Bencharit, Sompop
name: Hosseini, Bashir
name: Byrd, Warren C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A missing or deficient buccal alveolar bone plate is often an important limiting factor for immediate implant placement. Titanium dental implants enhanced with porous, tantalum-based trabecular metal material (PTTM) are designed for osseoincorporation, a combination of vascularized bone ingrowth and osseointegration (bone on-growth). Demineralized bone matrix (DBM) contains growth factors with good handling characteristics. However, the combination of these 2 materials in facial alveolar bone regeneration associated with immediate implant therapy has not been reported. A 65-year-old Asian woman presented with a failing central incisor. Most of the buccal alveolar bone plate of the socket was missing. A PTTM enhanced implant was immediately placed with DBM. Cone beam CT scans 12 months after the insertion of the definitive restoration showed regeneration of buccal alveolar bone. A combination of a PTTM enhanced implant, DBM, and a custom healing abutment may have an advantage in retaining biologically active molecules and form a scaffold for neovascularization and osteogenesis. This treatment protocol may be a viable option for immediate implant therapy in a failed tooth with deficient buccal alveolar bone.
Supplementary Information from Assessing the impact of fire on spiders through a global comparative analysis
Creators: name: McLean, Claire A.
name: Melville, Jane
name: Schubert, Joseph
name: Rose, Rebecca
name: Medina, Iliana
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: File file contains Figures S1 to S6, Tables S1 to S8 and supplementary references
LA STIMOLAZIONE TRANSCRANICA A CORRENTI DIRETTE (TDCS) NEL TRATTAMENTO DELLA DEPRESSIONE: EFFETTI TERAPEUTICI E INTERAZIONE CON LA TERAPIA PSICOFARMACOLOGICA.
Creators: name: FERRUCCI, ROBERTA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: INTRODUZIONE La stimolazione transcranica con correnti dirette (transcranial Direct Current Stimulation, tDCS) � una metodica di stimolazione cerebrale non invasiva che consiste nell?applicazione sullo scalpo di corrente continua di bassa intensit� non percepibile dal soggetto stimolato; la corrente � in grado di attraversare la teca cranica fino alla corteccia cerebrale. Negli ultimi anni tale metodica � stata utilizzata nello studio dei processi cognitivi, sia nei soggetti sani che nei pazienti affetti da disturbi neurologici e psichiatrici. Nessuno tra gli studi pubblicati ha sinora riportato gravi effetti collaterali o reazioni avverse. Nell?ambito specifico delle patologie psichiatriche la tDCS ha trovato gi� dagli anni ?60 numerose applicazioni evidenziando effetti benefici. Tali risultati sono ulteriormente consolidati in recenti studi in cui la tDCS sembra svolgere un ruolo importante nella modulazione di quelle aree che nella depressione risultano essere ipoattive e iperattive ed esercitare cos� un effetto antidepressivo. Gli studi sulla depressione lieve e moderata hanno dimostrato che la tDCS ha un?efficacia terapeutica significativamente superiore al placebo e sovrapponibile a quella della Fluoxetina, ma con maggiore rapidit� di azione e minori effetti collaterali rispetto a quest?ultima. In questo studio abbiamo esaminato le interazioni tra la tDCS e la terapia farmacologica in 82 pazienti depressi (unipolari e bipolari) che erano refrattari ad almeno un trattamento farmacologico. METODOLOGIA Il campione � composto da 82 pazienti affetti da depressione maggiore grave e farmaco resistente. Tutti i soggetti sono stati sottoposti ad un trattamento con tDCS (Corteccia Prefrontale Dorsolaterale), somministrato due volte al giorno a distanza di 4h, per 5 giorni consecutivi (intensit� di corrente: 2 mA per la durata di 20 minuti). Tutti i soggetti sono stati valutati in due tempi con la Beck depression Inventory (BDI), la Hamilton Depression Rating Scale: prima dell?inizio del trattamento (T0), alla fine dei 5 giorni di trattamento (T1). RISULTATI Dopo cinque giorni di trattamento la metodica ha prodotto un miglioramento significativo in entrambe le scale (BDI 29% � 36%, p<0.01; HDRS 18% � 9%, p<0.01), I risultati hanno dimostrato che l?uso delle benzodiazepine � associato ad un aumento dei punteggi alla scala BDI (+5.8 punti) (p<0.01) mentre gli altri antidepressivi hanno un effetto contrario (p<0.01). CONCLUSIONI In conclusione, la tDCS pu� essere una strategia terapeutica complementare ed adiuvante nella malattia depressiva. L'uso di benzodiazepine ostacola l'efficacia tDCS mentre l'uso degli antidepressivi sembra avere un effetto migliorativo, pertanto, il trattamento farmacologico deve essere sempre considerato nell'interpretazione dei dati.
Trustworthiness of detectors in quantum key distribution with untrusted detectors
Creators: name: Qi, Bing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Measurement-device-independent quantum key distribution (MDI-QKD) protocol has been demonstrated as a viable solution to detector side-channel attacks. One of the main advantages of MDI-QKD is that the security can be proved without making any assumptions about how the measurement device works. The price to pay is the relatively low secure key rate comparing with conventional quantum key distribution (QKD), such as the decoy-state BB84 protocol. Recently a new QKD protocol, aiming at bridging the strong security of MDI-QKD with the high efficiency of conventional QKD, has been proposed. In this protocol, the legitimate receiver employs a trusted linear optics network to encode information on photons received from an insecure quantum channel, and then performs a Bell state measurement (BSM) using untrusted detectors. One crucial assumption made in most of these studies is that the untrusted BSM located inside the receiver's laboratory cannot send any unwanted information to the outside. Here, we show that if the BSM is completely untrusted, a simple scheme would allow the BSM to send information to the outside. Combined with Trojan horse attacks, this scheme could allow Eve to gain information of the quantum key without being detected. To prevent the above attack, either countermeasures to Trojan horse attacks or some trustworthiness to the "untrusted" BSM device is required.
description: 6 pages, 2 figures
title: Entwicklung und Optimierung einer kleintechnischen Anlage zur Behandlung galvanischer Abwässer mittels Aersolbasierter Eliminierung (ABE)
Creators: name: Lübke, Steffen
Publisher: name: Bergische Universität Wuppertal
Year: 2022

description: Per- and polyfluorinated surfactants (PFAAS) are hydrophobic and lipophobic substances, which are resistant against extreme conditions. PFAAS are essential for many industrial processes. Disadvantages are observed persistent, bioaccumulative and toxic properties. Some of these compounds are classified as persistent organic pollutants (POPs).
 In chromium electroplating, PFAAS are used for occupational safety by chromic mist suppression and to improve product quality. Fluorine-free alternatives are not available due to the extreme oxidizing chromic bath conditions. To reduce PFAAS emissions, an efficient wastewater treatment is required. Expensive sorption processes with ion exchange resins are used so far. The aerosol-based elimination (ABE) is a promising, alternative method.
 In this work, the ABE was further studied. Goal was the development and optimization of a laboratory-sized ABE plant for PFAAS contaminated waste water treatment. First topic was the optimization of small bubble generation inside the contaminated water. Camera experiments showed best results for fritted glass and sintered metal plates with small pore sizes, which was confirmed by ABE control experiments.
 In an upscaling procedure, an ABE plant for treatment of a larger stock of PFAAS contaminated waters was developed and optimized. Elimination rates > 99 % were achieved. The PFAAS enriched aerosol was separated by a demister and collected in an aerosol fraction. To reduce unwanted PFAAS and chromium emissions, a closed loop system was installed. Further parameters affecting the elimination results, e.g. stock volume, pump circulation rate, matrix effects and water column height were studied to increase ABE performance.
 Analysis of the collected concentrate fraction showed PFAAS enrichment about a factor of 20 – 30. Inorganic matrix concentrations remained unaffected by ABE, but matrix ion strength influenced aerosol formation.
 Since the developed ABE planed showed promising results, treatment procedures for PFAAS recycling were studied. Further PFAAS enrichment in the concentrate fraction could be achieved by a second stage ABE and a foam skimming process.
Integrated optical sensors on the Si₃N₄-organic hybrid (SiNOH) platform
Creators: name: Kohler, Daria
Publisher: name: KIT Scientific Publishing
Year: 2023
Subjects: Sensorik
integrierte Laser
organische Laser
photonische Wellenleiter
patientennahe Labordiagnostik
Sensors
integrated lasers
organnic lasers
photonic waveguides
point-of-care diagnostics

description: Ein wellenleiterbasierter Sensorchip wird demonstriert, der für Point-of-Care-Anwendungen geeignet ist. Der Biosensor wird mit Hilfe eines mathematischen Modells entworfen, mit dem die Sensitivität der Wellenleiter untersucht wird. Für die Lichteinkopplung in die Wellenleiter wird erstmalig eine neue Klasse von integrierten Laserquellen für sichtbare Wellenlängen untersucht. Die Funktionsfähigkeit des wellenleiterbasierten Biosensorchips durch Detektionsexperimente erfolgreich nachgewiesen.
Osteoarthritis and Sleep: The Johnston County Osteoarthritis Project
Creators: name: RENNER, JORDAN
name: HELMICK, CHARLES
name: ALLEN, KELLI
name: DEVELLIS, BRENDA
name: JORDAN, JOANNE
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Little is known about the association of symptomatic osteoarthritis (OA) with sleep disturbance. We compared the prevalence and severity of current sleep problems among individuals with and without symptomatic hip or knee OA in a large, community-based sample.
Projeto poético: princípios éticos e estéticos no repertório cancioneiro de Antônio Carlos Belchior
Creators: name: Caviola, André Luiz Rocha Mattos
Publisher: name: Zenodo
Year: 2022
Subjects: Belchior.
Projeto Poético.
Mediação e Recepção.
Pesquisa em Artes.

description: A presente dissertação tem como objetivo investigar o projeto poético (SALLES, 2011) de Belchior e suas historicidades a partir dos materiais que não só traduzem suas experiências em diferentes contextos e espaços, mas contribuem para o processo de construção de sua obra. Para alcançar esse objetivo, buscou-se a compreensão dos valores éticos e estéticos representados pelo artista e como se apresentam em seu repertório cancioneiro. Num primeiro momento, busca-se apresentar a trajetória do artista e como essa proposta se articula dentro do campo de pesquisa artístico. No que diz respeito ao estudo do projeto poético, foram selecionadas nove canções para serem analisadas, organizadas a partir de diferentes fios condutores que atribuem sentido e singularidade à sua produção: a narrativa do migrante nordestino; a relação conflituosa entre modernidade e subdesenvolvimento; e as diferentes experiências construídas por meio de um campo de cruzamentos que se estabelece em seu repertório. Esses fios condutores não atuam de forma independente entre si. Pelo contrário, eles se complementam na obra do artista e na experiência estética de suas canções. Essa dissertação se ampara numa perspectiva de pesquisa sobre artes (REY, 1996), em que a ênfase do estudo é direcionada para a obra de arte a partir do seu produto e seus processos de significação. São considerados, também, os parâmetros verbo-poéticos, tecno-estéticos e a articulação entre a linguagem e as representações das realidades históricas nelas envolvidas (NAPOLITANO, 2016, 2015). Como ferramenta analítica para análise das canções, esta pesquisa se assenta em duas perspectivas: a primeira delas diz respeito à apreensão empírica da canção (TATIT, 2012, 2003) e a segunda baseia-se na análise da canção enquanto texto associado a um entendimento antropológico do fenômeno literário, ao considerar o papel mediador do texto ficcional, entre o imaginário e o real (ISER, 2013).
THE MELATONIN PROTECTIVE ROLE IN AN ORGANOTYPIC MODEL OF SPINAL CORD INJURY SECONDARY DAMAGE
Creators: name: COCCHI, MARCO ANGELO
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Spinal cord injury (SCI) is characterized to be a two-step process composed by the primary lesion consisting of the initial trauma and the secondary damage, characterized by multiple processes including inflammation, oxidative stress and cell death that lead to a significant expansion of the original damage and to an increase of the functional deficit. Among the aforementioned processes, the oxidative stress plays a significant role in pathophysiology of SCI. In this study, we evaluated the role of melatonin, potent antioxidant and immunomodulator indoleamin, on the oxidative stress, the tissue viability and the neuritic plasticity deriving from the gray matter in an experimental model of organotypic cultures. These cultures consisted of Sprague Dawley rat spinal cord slice treated with hydrogen peroxide (H2O2). In five experimental groups, A) Control Group (CTR) ? Organotypic spinal cord slice culture (350?m); B) Stressed Group (H2O2) ? Organotypic spinal cord slice culture (350?m) exposed to H2O2 (50 ?M); C) Control Group treated with melatonin (10-5M) of 24 hours (CTR+MEL) ? Organotypic spinal cord slice culture (350?m) treated with melatonin for 24 hours; D) Treated Group (H2O2+MEL-POST) ? Organotypic spinal cord slice culture (350?m) exposed to H2O2 (50 ?M) and treated after 24 hours with melatonin (10-5M) for 24 hours; E) Treated Group (H2O2+MEL-PRE) ? Organotypic spinal cord slice culture (350?m) pre-treated with melatonin (10-5M) for 24 hours (50 ?M) and exposed to H2O2 for other 24 hours. We investigated the slice cellular death by propidium iodide (PI) assay, the slice vitality by MTT assay, the superoxide dismutase (SOD) and total thiols (SH) levels for the contrast to the oxidative stress, the neuronal (NeuN) and the synaptophysin (Syp) immunopositivity. Melatonin significantly decreased the number of dead cells, increased slice vitality, mainly in slices treated before H2O2 exposition. Melatonin enhanced SOD immunopositivity, contrasted total thiols decrease, attenuated Syp reduction and increased NeuN immunopositivity. Overall, these findings suggest that melatonin may exert a potentially beneficial effect upon the progression of SCI secondary damage, protecting the tissue from a further degeneration.
C*-norms for tensor products of discrete group C*-algebras
Creators: name: Wiersma, Matthew
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: Let $Γ$ be a discrete group. We show that if $Γ$ is nonamenable, then the algebraic tensor products $C^*_r(Γ)\otimes C^*_r(Γ)$ and $C^*(Γ)\otimes C^*_r(Γ)$ do not admit unique $C^*$-norms. Moreover, when $Γ_1$ and $Γ_2$ are discrete groups containing copies of noncommutative free groups, then $C^*_r(Γ_1)\otimes C^*_r(Γ_2)$ and $C^*(Γ_1)\otimes C_r^*(Γ_2)$ admit $2^{\aleph_0}$ $C^*$-norms. Analogues of these results continue to hold when these familiar group $C^*$-algebras are replaced by appropriate intermediate group $C^*$-algebras.
description: 6 pages, v2 contains minor changes and an extra remark. To appear in Bulletin of the London Mathematical Society
title: Die Darstellung des russischen Terrormilieus in Boris Savinkovs Romanen "Kon' blednyj" und "To, čego ne bylo" im Vergleich zu seiner Autobiografie "Vospominanija terrorista"
Creators: name: Haberfellner, Paul
Year: 2021

description: Die vorliegende Masterarbeit setzt sich mit dem Schaffen des Schriftstellers und Terroristen Boris Savinkov (1879–1925) auseinander, dessen Bekanntheit sich seinerzeit vor allem auf seinen hohen Rang innerhalb der Partei der Sozialrevolutionäre gründete. Untersucht werden einerseits die Romane Kon’ blednyj und To, čego ne bylo, andererseits die Autobiografie Vospominanija terrorista. Die Analyse kommt zu dem Schluss, dass sich die fiktionalen Texte durch verschiedene Merkmale von der Autobiografie unterscheiden, was nicht zuletzt am Wahrheitsanspruch der letzteren liegt. Zusätzlich geht es um die Frage, ob in Savinkovs Texten Terrorist*innen in bestimmte Kategorien eingeteilt werden können.
description: This master thesis aims to analyse the novels Kon’ blednyj and To, čego ne bylo and the autobiography Vospominanija terrorista by the writer and terrorist Boris Savinkov (1879–1925), who was a notorious member of the Russian Socialist Revolutionary Party. The thesis draws the conclusion that there are several striking differences between how events are descripted in the novels on the one hand and in the autobiography on the other. Moreover, the study finds, that Savinkov creates certain “types” of terrorists.
Prevalence of Hip Symptoms and Radiographic and Symptomatic Hip Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project
Creators: name: NELSON, A. E.
name: FANG, F.
name: RENNER, J. B.
name: DRAGOMIR, A. D.
name: KALSBEEK, W. D.
name: HOCHBERG, M. C.
name: WOODARD, J.
name: HELMICK, C. G.
name: LUTA, G.
name: JORDAN, J. M.
name: ABBATE, L. M.
name: SCHWARTZ, T. A.
name: CALLAHAN, L. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To report contemporary estimates of the prevalence of hip-related osteoarthritis (OA) outcomes in African-Americans and Caucasians aged ≥ 45 years.