title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ ÐºÑÐ¼Ð°ÑÐ¸Ð½Ð°-ÑÑÐ¸ÑÐµÑÐ¿ÐµÐ½Ð¾Ð² Ð² ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð²Ð¸ÑÑÑÐ½ÑÑ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¹ Ð½Ð° Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Study of antiviral activity of coumarin-triterpene derivatives in the treatment of viral infections at animal models
Creators: name: ÐÑÑÐ°ÑÐ¾Ð², Ð®ÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ ÐºÑÐ¼Ð°ÑÐ¸Ð½Ð¾Ð²
Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð¼Ð¾Ð´ÑÐ»Ð¸ÑÑÑÑÐµÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
Ð»ÐµÑÐ°Ð»ÑÐ½Ð°Ñ Ð³ÑÐ¸Ð¿Ð¿Ð¾Ð·Ð½Ð°Ñ Ð¿Ð½ÐµÐ²Ð¼Ð¾Ð½Ð¸Ñ
ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾-ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ Ð¸Ð½ÑÐµÐºÑÐ¸Ñ
Ð³ÐµÑÐ¿ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÐºÐ¾Ð½ÑÑÐ½ÐºÑÐ¸Ð²Ð¸Ñ
coumarin derivatives
antiviral effect
immunomodulatory effect
lethal influenza pneumonia
respiratory syncytial infection
herpetic conjunctivitis

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description: This work is devoted to the study of the protective activity of preparations of hybrid coumarin-triterpene derivatives in models of lethal influenza pneumonia and respiratory syncytial infection at mice and herpetic conjunctivitis at guinea pigs. In the course of studies, a number of substances from the previously synthesized group of drugs were found to have the ability to reduce the monitored indicators of the severity of the course of diseases and, in general, to alleviate the condition of experimental animals. This effect is observed in the same substances for viruses of different groups, and the effect on experimental animals is weaker than for specialized drugs, it gives us a reason to believe that the studied samples have not antiviral, but immunomodulating activity. Continuing of study these substances may be promising and allow us to bring a new drug to the market.