cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Herausforderungen der Klimawandelanpassung im Immobiliensektor - Die Klimarisikoanalyse als Erweiterung des Risikomanagements
Creators: name: Obojkovits, Yasmin
Publisher: name: TU Wien
Year: 2024
Subjects: subject: Physische Klimarisiken
subject: EU-Taxonomie
subject: Risikobewertung
subject: Versicherung
subject: Anpassungsmaßnahmen

description: Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprueft - gesperrte Arbeit (bis 2026-09-30+02:00)
description: Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers
Phronima sedentaria
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima sedentaria

description: Phronima sedentaria (Forsskål)
Cancer sedentarius Forsskål, 1775: 95–96.
Gammarus sedentarius — Schousboe, 1802: 11, figs 1–6.
Phronima sedentaria — Latreille, 1803: 291.
Phronima custos Risso, 1816: 121, pl. 2, fig. 3.
Phronima borneensis Bate, 1862: 318, pl. 51, fig. 3.
Phronima novaezealandiae Powell, 1875: 294, pl. 21, figs 1 & 2.
Phronima neozelanica Thomson & Chilton, 1886: 150.
Phronima spinosa Bovallius, 1887: 25.
Phronima tenella Stebbing, 1888: 1354–1356, pl. 161A.
Phronima affinis Vosseler, 1901: 20, pl. 1, figs 12–16.
Type material The holotype of Cancer sedentarius is in the ZMUC (Forsskål coll.): in spirit.
Type material of synonyms
Type material of P.custos seems to be lost, although the ANSP has a female specimen embedded in a dried salp (CA 2689) from the Guérin­Méneville collection (No. 443) which may represent type material (see Zeidler 1997).
Type material of P. borneensis could not be found at the BMNH or MNHN and is considered lost.
Type material of P. novaezealandiae could not be found in any museum in New Zealand, or at the BMNH and is considered lost.
Type material of P. spinosa could not be found at the SMNH, ZMUC or in Uppsala and is considered lost.
The holotype of P. tenella is in the BMNH (89.5.15.205): mounted whole on a microscope slide.
The holotype of P. affinis is in the Zoological Museum, Kiel University, Germany (Cr. 0318).
Remarks
This is the only species of Phronima in which the second antennae of the males are reduced. Females of this species can be confused with P. atlantica, especially when dealing with juveniles, but the pleonites of P. sedentaria possess a posterodistal spinose process which is absent in P. atlantica. It is also similar to P. solitaria, but males of that species have well­developed second antennae, and in females the carpus of pereopod 5 has a strong medial tooth adjacent to the anterior tooth.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 11, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Effect of fetal alcohol on mammary carcinogenesis
Creators: name: Polanco, Tiffany
Publisher: name: No Publisher Supplied
Year: 2011

description: Altered fetal programming as a result of a suboptimal in utero environment can increase disease susceptibility in adulthood. Alcohol exposure in utero increases mammary cancer risk in rodents. Mammary development affects breast cancer risk, as a denser, hyperproliferative gland increases mammary cancer risk. Therefore we hypothesized that alcohol exposure in utero increases the action of the IGF-I/E2 system leading to hyperproliferative mammary glands and ultimately increased cancer susceptibility. We first established a model where fetal alcohol leads to increased mammary tumor susceptibility. Pregnant rats were fed a liquid diet containing ethanol (alcohol-fed), a control isocaloric liquid diet, or rat chow ad libitum. Alcohol-fed dams were acclimated to increasing concentrations of ethanol (2.2% and 4.4%), then fed 6.7% ethanol from day 7 to 21 of gestation. To investigate tumorigenesis, N-nitroso-N-methlyurea (NMU) was administered to induce tumor formation at postnatal day 50. Rats were palpated for  iii  tumors weekly and euthanized at 23 weeks post-NMU injection, or in a second study at 16 weeks post-injection. At 16 weeks post-injection, tumor multiplicity was greater and tumor latency was decreased in the alcohol-fed group compared to controls. At 23 weeks post-NMU injection alcohol-fed animals developed more malignant tumors and more estrogen receptor-α negative tumors with less IGF binding protein-5 expression relative to controls, indicative of poor prognosis breast cancer in women. To determine if mammary development is altered by in utero alcohol exposure, a study was conducted in which animals were euthanized prepubertally and postpubertally. Mammary glands from alcohol-fed animals showed increased proliferation and aromatase expression prior to and immediately after puberty. Mammary and hepatic IGF-I mRNA levels were also higher in alcohol-fed animals. In a separate study it was determined that alcohol-fed animals also have higher circulation E2 than controls. Together, these data indicate that alcohol exposure in utero increases susceptibility to mammary tumorigenesis, and leads to a tumor phenotype indicative of poor prognosis breast cancer. These changes may be related to enhanced early mammary development via the IGF/E2 systems. Therefore, women born to mothers who drank alcohol during pregnancy may represent a high risk group for aggressive breast cancer.
Developing a time-dynamic, label-free assay for apoptosis based on optical Gabor filtering
Creators: name: Pasternack, Robert M
Publisher: name: No Publisher Supplied
Year: 2011

description: Apoptosis is a fundamental process in the homeostasis and development of mammals, dysfunction of its regulation is implicated in human disease, and it is of growing interest as a possible therapeutic target (especially in cancer). An apoptosis assay that is sensitive, quantitative, and label-free would therefore be useful in cancer drug discovery by offering a direct, time-dynamic in-situ assessment of apoptotic response to drug candidates.    This thesis documents the development of optical Gabor filtering into an apoptosis assay. Optical Gabor filtering was developed as an improvement to optical scatter imaging (OSI) capable of optical scatter-based detection of object size and aspect ratio without the need for a predictive scatter model or extrinsic labeling. Two versions of the optical Gabor filtering instrument (LCD-based and DMD-based). By applying a series of Gabor filters with varying spatial frequencies and orientations, a series of filtered images can be generated and processed to extract morphological parameters of interest. The parameters of size, orientedness and aspect ratio are developed and tested using polystyrene microspheres,  marine diatoms and collagen gelation, respectively. Orientedness and aspect ratio are employed as morphometric parameters to study dynamic morphological alterations in apoptosis.     Aspect ratio measurements in apoptotic iBMK cells show a differential aspect ratio response to apoptosis induction by bax/bak expressing and bax/bak knockout cell variants. To determine the biological source of these variations, multimodal image acquisition of fluorescently-labeled mitochondria alongside Gabor filtered data is used in apoptotic endothelial cells. Results of this study show a drop in orientedness 1-2 h post-STS treatment  in mitochondria-rich regions (reconnoitered by fluorescence) concomitant with mitochondrial fragmentation but absent elsewhere. This dynamic is similar but not identical to that observed from iBMK cells. OSI imaging of apoptotic BAEC also revealed that a previously reported drop in optical scatter image ratio in the first hour of apoptosis is also associated with mitochondria-rich regions. In the future, the differences between optical responses of BAEC and iBMK apoptotic cells will be elucidated with fluorescent tracking of mitochondria-rich areas in iBMK. Classification and other computational methods could also be employed to directly evaluate the optical Gabor-filtered data in the future.
Galeocerdo Muller & Henle 1837
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Galeocerdo

description: Genus Galeocerdo Müller & Henle, 1837
Type species
Squalus cuvier Péron & Leseur, 1822, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 99, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Immune mechanisms of FLASH radiotherapy: a new paradigm for lung cancer cure
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is not only the most common tobacco-related cancer, it is by far the leading cause of cancer deaths worldwide. Radiation therapy plays a crucial role for most patients who have the potential of being cured of lung cancer, and is increasingly used with the goal of cure in selected patients with lung cancer from early to metastatic stages. Immunotherapy has recently become an important treatment for incurable metastatic lung cancer, and is just starting to play a role in potentially curable lung cancer. Radiation therapy can increase the effectiveness of immunotherapy. Used together even metastatic lung cancer can sometimes be cured, but we do not yet know how to do so reliably. Furthermore, the side effects of radiation therapy and immunotherapy limit their ability to achieve cures safely. Increasing the curative effect on lung cancer while decreasing collateral damage to normal organs is the key to the success of any cancer therapy.

 Ultra-fast “FLASH” radiation therapy (completed in under one second compared to several minutes conventionally) promises to be a breakthrough in curative radiation therapy for lung cancer. FLASH would solve the problem of precisely treating moving targets like lung tumors by “freezing” the motion, allowing more intense treatment to the tumor while reducing unnecessary radiation to the surrounding normal organs. Remarkably, preliminary experiments of biological effects of FLASH in mice have shown that it produces better killing of lung cancer cells but dramatically less damage to the lungs. These effects appear to involve different immune responses in tumors and normal tissues compared to those produced by conventional speed radiation.

 We propose to study the immune signature produced by FLASH in order to understand how to maximize its beneficial effects, and how it might interact with immunotherapy to achieve more reliable cures with minimal injury to normal organs. If these biological results translate to humans, FLASH would transform curative lung cancer treatment. Importantly, Stanford and SLAC National Accelerator Lab are collaborating on a parallel research program to develop a next-generation medical linear accelerator capable of delivering FLASH to humans, providing a direct path to clinical realization of the biological benefits of FLASH in addition to its advantages in precision targeting.
Fetal nicotine exposure develops heart ischemia-sensitive phenotype
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking during pregnancy is associated with numerous adverse outcomes for the developing fetus, as well as an increased risk of poor health in adulthood. Although the safety of nicotine use (nicotine gum or patch) during pregnancy has been evaluated in short-term human trials, the long-term effects of fetal nicotine exposure are uncertain. In addition, electronic cigarette (e-cigarette), an electronic nicotine delivery system has been introduced in the global market during the past ten years. Thus, nicotine addiction and nicotine abuse are becoming a potential health concern in the 21st century. Recent studies have shown that e-cigarettes can alter heart function and affect blood hematology, however, little direct work has been done on the health effects of e-cigarettes products on prenatal development or adult health. Therefore, study of the long-term consequences of fetal nicotine exposure either from tobacco smoking, NRT or e-cigarette has significant public health impact and clinic implications. Our recent studies have demonstrated that perinatal nicotine exposure increases heart ischemic injury and dysfunction in postnatal life. However, the molecular mechanisms remain unclear. In this project, we test the novel hypothesis that antenatal nicotine exposure enhances cardiac angiotensin II type 2 receptor (AT2R) gene expression through DNA methylation mechanism, leading to development of heart ischemia-sensitive phenotype in offspring. To test this hypothesis, we propose three specific aims in our well-established animal model of nicotine-treated pregnant rats and their offspring. Project outcomes are expected to provide new evidence that nicotine exposure during pregnancy could modify cardiac AT2R gene expression. This epigenetic change of AT2R gene by DNA methylation provides a potential mechanistic link between smoking/nicotine use by pregnant women and the development of cardiac ischemic disease in their offspring. Understanding the mechanism is of fundamental physiologic importance in its own right, as well as having considerable clinical relevance for improving cardiac function, and reducing nicotine-induced cardiovascular disease.
The United States of Europe
Creators: name: Pappalardo, Salvatore
Publisher: name: No Publisher Supplied
Year: 2011

description: This dissertation is a comparative study of literary Europeanism in the late-Habsburg Empire. The biographies and aesthetic projects of Robert Musil, Italo Svevo and James Joyce are deeply embedded in the multinational fabric of the Austrian-Hungarian Empire, and their novels become part of what might be defined as a ―transnational Habsburg literary canon.‖ Their works create a highly politicized, fictional projection of multicultural Austria–and by extension, of a multicultural Europe–anchored in the polyglot border town Trieste. The primary texts I examine are Musil‘s The Man without Qualities (Der Mann ohne Eigenschaften), published between 1930 and 1942, Svevo‘s 1923 novel Zeno’s Conscience (La Coscienza di Zeno), and Joyce‘s Finnegans Wake of 1939. I read these texts against the background of Austrian history and in combination with current theoretical debates on nationalism. I argue that the origins of a cultural and political Europeanism in the Habsburg Empire can be traced back to forms of early modern regional patriotism, which was divorced from national identity and characterized by loyalty to the local traditions of linguistically and culturally heterogeneous territories or cities. The rise of nationalism in the aftermath of the 1848 revolutions largely replaced these earlier forms of regional allegiance. I examine the survival of vestigial remnants of this pre-national logic in the literary representations of Trieste, a city at the crossroads of German, Italian and Slovene cultures. The high modernist fiction of Musil, Svevo and Joyce conjures an image of Trieste as a microcosm of the multinational empire and an urban experiment of a future United States of Europe. Their fictional characters not only subscribe to a cultural and political Europeanism, but refuse, through their flexible loyalties and shifting allegiances, to fully commit to the concept of nation.
Locating Korean American adoptees
Creators: name: Park, Jane J.
Publisher: name: No Publisher Supplied
Year: 2011

description: Based on multi-site ethnographic methods and in-depth interviews, my dissertation explores identities and subjectivities of Korean American adoptees. Korean adoptee experiences of racial discrimination and the stigma of adoptee status enable their out-of-place subjectivity, indicating that a common identity can be constructed over the life course out of everyday mundane interactions. Drawing on methodology of Willis’ “ethnographic imagination” (2000), I examine mundane social interactions as ethnographic moments that engender and sustain out-of-place subjectivity.   As Korean adoptees mature, shared experiences of being alienated and stigmatized intensify the affect that they feel toward each other. The affective identification that they feel provides the bases upon which they can build a lasting bond, an emotional kinship. This creation of bond is aided by spaces centered on adoptees, such as culture camps, adoptee gatherings, and heritage tours, where Korean adoptees meet and interact. I further analyze the sociocultural factors that give force to the adoptee bond, drawing on the concepts of “racial melancholia” (Eng and Han, 2000) and “haunting” (Gordon, 1997) to comprehend this unique emotional bond among Korean adoptees.    In contrast to the iconic representations of Korean adoptees/Korean Americans in media as perpetual foreigners, Korean adoptees’ “stories” illustrate that they are just as much a product of varied American cultural milieus as anyone. As such, generational differences are found among Korean adoptees of varying age cohorts, deriving from historically different cultural discourses and practices, as well as changing sociocultural contexts in which international adoptions have taken place. By listening to adoptees from various life stages conceptualize their adoptee status and identity, this dissertation underscores the fact that adoptee identity is a product of complex process, emerging over the life course rather than a static category.
Everyday smoking contexts and practices of bisexual young adults
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco use is increasingly concentrated within marginalized groups, like sexual minorities. Among sexual minorities, bisexuals are at extremely high risk. Bisexuality is the fastest growing sexual identity in the U.S., yet in-depth understanding of how and why high bisexual smoking rates persist is lacking. This is needed to develop tailored interventions that can reduce high smoking rates within these groups. Many studies have investigated individuals’ characteristics (e.g., mental health) and smoking behavior. Now, interest is growing in understanding the influence of people’s everyday contexts (e.g., neighborhood tobacco retail), social contexts (e.g., acceptability of smoking), and social practices (e.g., routine smoke breaks) on tobacco use behavior. New research methods are needed to uncover the links between individual and contextual risk factors to tobacco use. We will examine the unique mechanisms driving smoking among bisexual young adults by comparing their everyday smoking contexts and practices with those of their homosexual and heterosexual peers. We will analyze existing pilot data and new data collected with young adult smokers in the San Francisco Bay Area (n=57; ages 18-26). Participants will complete surveys of (non)smoking situations for 30 days on a smartphone app that will track their location. Surveys will capture internal (e.g., craving intensity) and external (e.g., seeing smoking) factors linked to smoking episodes. We will guide interviews on smoking location experiences and practices with maps of participants’ data. We will first analyze data for each sexual identity group. We will use transcripts to identify smoking location types, experiences of smoking contexts and sexual identity, and the roles of smoking. We will use survey data to identify smoking predictors such as location type, time of day, and smoking triggers (e.g., lighters). We will assess participant exposure to tobacco retail outlets with mapping software. We will integrate findings in a table to compare smoking factors for each sexual identity group. We will describe participant reactions to participating in the study via transcript analysis. Findings will advance understanding of the mechanisms driving tobacco use disparities among sexual minorities, guide tailored intervention development, and inform future studies employing this method.
Phronima atlantica Guerin-Meneville
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima atlantica

description: Phronima atlantica Guérin­Méneville
Phronima atlantica Guérin­Méneville, 1836a: 21, pl. 25, fig. 4.
Type material
Two syntype females of P. atlantica are in the ANSP (CA 2687), in the Guérin­ Méneville collection (No. 444): once alcohol preserved, now dry (see Zeidler 1997).
Remarks
The current citation for the original description of this species is contentious. In the past most authors have cited Guérin­Méneville 1836b (p. 7–9; pl. 18, fig. 1) (e.g. Shih 1969; Spamer & Bogan 1992, 1994; Vinogradov et al. 1982), but next to P. atlantica, Guérin­Méneville refers to his 1836a publication (pl. 25, fig. 4). The figures in both publications are the same, but the fact that Guérin­Méneville refers to his 1836a publication in reference to P. atlantica indicates that this pre­dated his 1836b paper and should therefore become the original citation for this species. That 1836a was probably published well before 1836b is supported by the fact that other species described in his 1836b paper are not listed in 1836a.
Regarding the publication “Iconographhie du Règne Animal de G. Cuvier…” (Guérin­ Méneville 1836a), Stebbing (1888) says, “This work was published in livraisons between 1829 and 1844. The Plates containing Amphipoda probably all belong to the early part of 1836. An advertisement in the “Quarante­cinquième livraison. Crustacés. Pl. 35.,” says, “La 46 e et dernière livraison se composera du Texte descriptif de l’Iconographhie et paraîtra fin mars 1838 ”, but the promise was not, it appears, fulfilled till the end of 1843. The specific names, however, being given on the Plates, will carry the date 1836.”
The similarity of this species to P. sedentaria has already been discussed under that species.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 12, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
title: Kurzgefasste Geschichte zum Löwenbräu in München; ca. 1900
title: [illustrirt von Karl Wolf] = Histoire abrégée de la Brasserie par actions du Lion a Munich = Short history of the Löwenbräu Brewery in Munich
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Nebent.: Paris 1900. - Enth. S. 23 - 32: Kurzer Führer zu den Hauptsehenswürdigkeiten von Paris. - Text dt., franz. u. engl.
Effects of Third Hand Smoke on Mitochondrial Genetic/Epigenetics and Their Inheritance Pattern
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Third Hand Smoke (THS) is made of toxins that stick to fabric, carpet, and upholstery that have been exposed to cigarette smoke. Not all THS can be removed with household cleaners. Therefore, many people are unknowingly exposed to THS. Long term THS exposure causes metabolic problems. It has been shown that THS-exposed mice have lower energy in the form of the cell currency called ATP and increased triglycerides. When removed from THS, some symptoms return to normal by 6 months. Interestingly, symptoms of altered metabolism do not. This suggests that THS affects the part of the cell that regulates metabolism, the mitochondria. Mitochondria have its own DNA (mtDNA) that is separate from the rest of the DNA in the cell. We believe that metabolic stress is induced by THS due to changes in the mtDNA and that these changes can be inherited by offspring. These changes to mtDNA may be genetic mutations, or epigenetic changes. Epigenetic changes are changes to DNA that do not include changes to the sequence itself. One example is the addition of an extra molecule called a methyl group to the DNA, which can make a gene work less efficiently, much like DNA mutations might. We will investigate:
 The effects of THS on genome and epigenome of mitochondria. Because many of the genes involved in metabolism are coded in the mitochondrial genome, we evaluate mtDNA for genetic and epigenetic changes. Early data has shown that mtDNA isolated from THS-exposed mice have more methylations. This may be contributing to decrease expression of genes needed by the mitochondria, resulting in lowered activity for the electron transport chain, which would result the lowered ATP that we have observed.
 Investigate if the effects of THS are transgenerational. Because some changes remain altered after toxin exposure has stopped, it is possible that these alterations can be passed onto the offspring. Genetic mutations have been well established to be inherited. Epigenetic inheritance has only been recently observed and examples revolve around metabolic dysfunction in response to toxin exposure.
 Our studies are novel because epigenetics of mtDNA has only been shown in small number of diseases. Our studies will help to understand of THS toxicity and whether it is passed on to the next generations, which will improve strategies for reversing the effects, impacting human health.
Notch3 in Human Lung Adenocarcinoma Pathogenesis and Heterogeneity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer related death worldwide. Non-small lung cancer accounts for 85% of diagnoses and the predominant subtype is lung adenocarcinoma (LUAD). KRAS mutant LUAD is strongly tobacco associated and has a poor prognosis due to resistance to current targeted therapies, that are effective in other adenocarcinoma subtypes, and poor response to conventional chemotherapy.

 Notch signaling in mammals is complex, with four receptors, five canonical ligands and multiple signaling activators. Normally, Notch ligands at the surface of one cell interact with receptors on an adjacent cell, triggering cleavage of the internal part of the Notch receptor leading to transport into the nuclease resulting in transcription of target genes. The Sweet-Cordero lab showed that while all 4 Notch receptors are expressed on the surface of cancer stem cells, only Notch3 signaling is essential for their ability to self-renew and significant evidence suggests that Notch plays a role in tumor formation. Further to this expression of transcriptional targets of Notch3 suggested poorer prognosis in LUAD patients. Whilst we have identified that Notch is important, a precise understanding of the mechanisms of Notch signaling in this disease is lacking, limiting our ability to target the Notch pathway therapeutically in LUAD.

 We hypothesize that aberrant Notch3 signaling is a critical pathway for survival and that Notch activation leads to gene expression changes that are important for driving human LUAD tumor initiation and maintenance. Patient-derived xenografts (PDX) models recapitulate important aspects of human cancer biology, particularly with regards to the role of intratumoral heterogeneity and self-renewal pathways. Thus, we will use PDX models developed in our laboratory to characterize the mechanisms of Notch3 activation and the downstream consequences of this activation in human LUAD. By identifying key components of the Notch signaling pathway in both the cancer stem cells and the tumor bulk we hope to identify new therapeutic targets. The development of new treatments for KRAS mutant lung adenocarcinoma would be a major advance for all Kras mutant lung adenocarcinoma patients.
title: Kurzvorstellung des Lehrkonzepts zum allgemeinen Lehrpreis
Creators: name: Friedrich-Schiller-Universität Jena. Multimediazentrum
name: Hameister, Ilka
name: Starke, Peter
name: Ziegler, Mario
Publisher: name: Friedrich-Schiller-Universität
Year: 2024
Subjects: subject: Lehrpreis
subject: Didaktik
subject: 370

description: Für ihr didaktisch herausragendes Lehrkonzept wurden in diesem Jahr Ilka Hameister, Peter Starke und Dr. Mario Ziegler (Fakultät für Sozial- und Verhaltenswissenschaften / Philosophische Fakultät) mit dem allgemeinen Lehrpreis der Universität Jena ausgezeichnet. Im Anschluss an die Preisverleihung gaben sie einen Einblick in ihr interdisziplinäres Blockseminar „Die Kontroverse um das Kontroversitätsgebot: Urteilsbildung aus politik- und philosophiedidaktischer Perspektive“.
description: Dies Legendi 2024: Let´s communicate! Diskurskultur in Lehrveranstaltungen
Impact of Smoking on Myeloproliferative Neoplasms
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Myeloproliferative neoplasms (MPN) are a group of blood cancers characterized by unrestrained production of red blood cells, platelets and white blood cells. Patients with MPN have 1) a high risk of developing blood clots, 2) debilitating symptoms such as itching, fatigue, headache and abdominal pain, and 3) can progress to acute leukemia which has a dismal prognosis. Chronic inflammation is a characteristic feature of MPN and not only drives many of the symptoms associated with the disease and promotes blood clots but also plays a key role in disease initiation and progression. Therefore, exposures like tobacco or potentially e-cigarette smoke likely have a negative impact on all three of the major problems in MPN. Thus, we will measure the impact of tobacco and e-cigarette smoke on blood clotting, symptom burden, and disease progression in MPN using our previously established MPN animal models, blood from MPN patients, and MPN patient reported outcomes in an online survey. This may lead to a stronger rationale for more aggressive smoking cessation counseling in MPN patients, increased incentive for patients to stop smoking due to improvement in symptoms, and may also lead to changes in treatment guidelines for MPN patients who continue to smoke.
Phronima solitaria Guerin-Meneville
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima solitaria

description: Phronima solitaria Guérin­Méneville
Phronima solitaria Guérin­Méneville, 1844: 21–22.
Phronima custos – Bate 1862: 318, pl. 51, fig. 2.
Phronima megalodus Stebbing, 1888: 1353–1354, pl. 162A.
Phronima atlantica var solitaria – Vosseler 1901: 23, pl. 2, fig. 5.
Type material
The holotype female of P. solitaria is in the ANSP (CA 2693) in the Guérin­Méneville collection (No. 446): once alcohol preserved, now dry (see Zeidler 1997).
Type material of synonyms
The holotype female of P. megalodus is in the BMNH (89.5.15.204): on two microscope slides.
Remarks
There is some doubt regarding the correct date for the citation of this species. Past reviewers (Vosseler 1901; Shih 1969, 1971) have cited Guérin­Méneville, 1836a, and, although this is the correct date for the plates, the text was not completed until the end of 1843 (see remarks on P. atlantica). Phronima solitaria was not figured in any of the plates, and was only described on p. 21 of the text, which was not published until 1844! This should therefore be the date used when citing this species (e.g. Spamer & Bogan 1992, 1994). Incidentally, the reference given by Shih (1969) for the original description of this species refers to P. atlantica.
Phronima solitaria was considered a mere variety of P. atlantica by Vosseler (1901) but Shih (1969) elevated it again to specific status, a decision which is supported by the examination of the type.
The similarity of this species to P. sedentaria has already been discussed under that species.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on pages 12-13, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
YANGI O'ZBEKISTONNING YANGI KONSTITUTSIYASI: EKOLOGIK MUAMMOLARNI YANGICHA YONDASHUV ASOSIDA BARTARAF ETISHNING NEGIZI
Creators: name: Mirislomov, Mirdavlat
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada sekin-astalik bilan yangi xavfga ega bo‘layotgan ekologik muammolarning O‘zbekiston Respublikasi Konstitutsiyasida yoritilish jihatlari, inson va fuqarolarning ekologik huquq, majburiyatlari keltirilgan.
Phronima pacifica Streets
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima pacifica

description: Phronima pacifica Streets
Phronima pacifica Streets, 1877: 128–130.
Type material
Type material of P. pacifica could not be found at the ANSP or USNM and is considered lost.
Remarks
The female of this species is easily distinguished from its congeners by the shape of pereopod 5. Males closely resemble P. colletti and in the past have been confused with it (Shih 1969), but the merus of pereopod 5 is distinctly wider than long, and the carpus is more trapezoid in shape.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 13, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Impact of splicing factor mutations in the context of tobacco exposure in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Before mRNA molecules direct the synthesis of proteins, intervening segments are removed in a process called splicing, leaving behind the sequences that code for protein. Mutations in genes coding for factors controlling splicing are commonly seen in cancer patients; however, how these mutations contribute to cancer is still unclear. In lung cancer, the splicing factor U2AF1 is frequently mutated in patients with a history of smoking. We seek to understand how this mutation alters the activity of genes associated with lung cancer.

 Our group and many others have discovered that mutations in U2AF1 lead to many mRNAs that are aberrantly spliced; however, the previous sequencing technology used does not provide the full mRNA sequence nor can we confidently infer which aberrant mRNAs are eventually translated into proteins. In this study, we are using a suite of methods in next-generation sequencing, biochemistry, and molecular and computational biology, to identify the sequences of complete mRNA molecules. In cells with a U2AF1 mutation, we will assess whether aberrantly spliced mRNAs continue to direct the synthesis of proteins and what effect these RNAs have on the activity of cellular processes. We will study the effects of the U2AF1 mutation in two different types of cells to provide clues on which mutation-associated changes contribute to the onset of cancer and which contribute to sustaining or advancing the disease.

 Given a recent report that the U2AF1 mutation causes enhanced survival of cancer cells during exposure to radiation, we will determine whether cells exposed to cigarette smoke have a growth advantage when they harbor the U2AF1 mutation over cells without that mutation. Lastly, we will focus on the large changes we see in the mutant cells in expression of the uridine phosphorylase gene, UPP1. This gene is known to be highly expressed in lung cancer and our preliminary data shows a shift in favor of more mRNA in the mutant. We will test whether this change in UPP1 mRNA alone supports enhanced survival of cancer cells to damage from tobacco smoke exposure. These findings will advance our understanding of how changes in mRNA processing affect cell function and could lead to novel approaches for treating diseases, including cancers, in which splicing is abnormal.
Інтеграційні та конкурентні аспекти формування механізму активізації інноваційного розвитку малого та середнього підприємництва
Creators: name: Городницький, Р. О.
Publisher: name: Zenodo
Year: 2023
Subjects: інновації, інноваційний розвиток, активізація, інноваційна активність, підприємство, підприємництво, конкуренція, інтеграція.

description: Систематизовано закономірності процесу активізації інноваційного розвитку в контексті перспективи розробки та впровадження новаторських рішень суб’єктами малого та середнього підприємництва. Представлено обґрунтування інтеграційно-конкурентного характеру здійснення заходів щодо активізації інноваційного розвитку малого та середнього підприємництва, що спирається на співпрацю та співробітництво широкого кола учасників процесів створення та впровадження нових рішень. Відзначено актуалізацію питань підвищення інноваційної сприйнятливості національного господарства в сучасному контексті інтеграції до глобалізованої світової економічної системи. Доведено, що використання переваг властивостей гнучкості та мобільності суб’єктів малого та середнього підприємництва в інноваційній сфері пов’язується або із розбудовою потужної інфраструктури організаційно-економічної підтримки новаторської активності бізнесу, а також із необхідністю налагодження між ними специфічного інтеграційно-коопераційного співробітництва. Представлено авторське бачення змістовного наповнення, визначення структури та складових механізму активізації інноваційного розвитку малого та середнього підприємництва. Доведено доцільність формування певної інноваційної екосистеми мережевого або кластерного виду взаємодії, що постає основою для формування механізму активізації інноваційного розвитку суб’єктів малого та середнього підприємництва. Дано обґрунтування ключових особливостей формування та функціонування механізму активізації інноваційного розвитку малого та середнього підприємництва.
Phronima bucephala Giles
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima bucephala

description: Phronima bucephala Giles
Phronima bucephala Giles, 1887: 215–217, pl. 3, figs 1 & 2.
Type material The type of P. bucephala could not be found at the BMNH and is considered lost.
Remarks
This species is most similar to P. colletti (Laval 1970) and P. bowmani (see Shih 1991).
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 14, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Phronima stebbingii Vosseler
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima stebbingii

description: Phronima stebbingii Vosseler
Phronima stebbingii Vosseler, 1901: 36–39, pl. 4, figs 4–10.
Type material Several syntypes of P. stebbingii are in the ZMB (17294): in spirit.
Remarks
This species is very similar to P. dunbari (see Shih 1991) but is readily distinguished from all other congeners by having pleonite 1 longer than pereonite 7.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 15, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Witnesses of atrocity and the preservation of memory
Creators: name: Passamano, Leigh-Ayna J.
Publisher: name: No Publisher Supplied
Year: 2011

description: This thesis aims to explore the relationship between memorial museums and survivors, the moral and ethical obligations between them, and best practices regarding this relationship. Using three museums as case studies, the Auschwitz-Birkenau State Memorial and Museum, United States Holocaust Memorial Museum and the future National September 11 Memorial and Museum, I will discuss the existing policies that dictate the relationship between memorial  museums and survivors. There are different types of relationships between survivors and a memorial museum which are generally determined by the survivor’s choice of how involved they want to be with the museum. This analysis will discuss measures that museums take to include survivors and the manner in which museums reach out to survivors. Additionally, the collecting practices of these museums will be explored in respect to how they address the acquisition of objects that could be considered personal property. This study will culminate in a set of recommendations for the relationship between memorial museums and survivors. The ethical issues surrounding the rights of survivors and museums’ plans for keeping them involved with the museum has applications in the creation of policy and codes of ethics in memorial museums in the United States and abroad.
Digital Surveillance to Identify Alternative & Emerging Tobacco Industry Mobilization and Influence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed project will explore the anti-tobacco policy and community advocacy activities generated between alternative and emerging tobacco actors including manufacturers, trade associations, wholesalers, vendors/retailers, and the tobacco user community as mobilized through digital technologies. Specifically, it will identify and measure how anti-policy digital assets and campaigns are created on the Internet and social media, and how they are activated and mobilized to influence the outcome and implementation of California state and local policies related to alternative and emerging tobacco regulation. Previous studies have examined retail and Internet tobacco vendors for their use of online marketing and social media engagement. During these studies, high levels of political advocacy was observed but not further studied. Hence, this study will specifically identify how digital platforms catalyze anti-policy activity and the specific strategies used by different tobacco actors to spread misleading and false information. The proposed study will conduct web surveillance, content mining, and data analysis to identify coordination of digital anti-policy campaigns. We will first compile a database of targeted industry actors comprised of manufacturers, trade associations, online vendors, distributors, and retailers actively doing business in the state of California. We will then use interdisciplinary methods in public health, computational science, and policy analysis to: (1) identify online assets (e.g. Internet pages, social media accounts, blogs, etc.) used by the industry; (2) automate collection of large volumes of data; (3) code and analyze data using machine learning for content related to advocacy activity, lobbying, and grass-roots efforts to block tobacco control bills; (4) assess the sentiment, geospatial, and networks characteristics of these activities; and (5) develop evidence to support targeted public awareness and counter marketing solutions. The proposed pilot research is responsive to all aspects of TRDRP's State and Local Tobacco Control Policy research goals. This includes generating evidence on how the ENDS industry uses now ubiquitous forms of digital technology in order to influence the outcome of CA tobacco-free policies and how they mobilize their constituent communities.
CLINICAL CHARACTERISTICS AND OUTCOME IN DOGS TREATED WITH TRANSSPHENOIDAL HYPOPHYSECTOMY FOR NON-FUNCTIONAL SELLAR MASSES
Creators: name: Hyde, Brittany Renee
Publisher: name: Washington State University
Year: 2022

description: Objective: To characterize the clinical features, neurological examination findings, diagnostic imaging results, histopathological findings, and outcome following transsphenoidal hypophysectomy (TSH) in dogs with non-functional sellar masses (NFSM).Study design: Multi-institutional retrospective study.
description: Methods: Medical records of dogs that underwent TSH for a confirmed NFSM were reviewed. Owners were contacted to assess long-term survivors.
description: Results: The most common clinical sign at presentation was mentation change (12/15). The average pituitary to brain ratio (P/B ratio) was 1.05 (0.6-1.4), and most dogs had a tumor imaging classification of 5B (8/14). The most common tumor type was pituitary adenoma (11/15). Peri-operative mortality was moderate (5/15), specifically when tumors were not adenomas. The median survival for all dogs was 232 days (0-1658), and when dogs that did not survive to discharge were excluded, the median survival time was 708 days. Seven out of 10 owners of long-term survivors responded, reporting an excellent (6/7) to good (1/7) outcome. Most dogs that survived the peri-operative period received post-operative adjunctive therapy (7/10).
description: Conclusion: Dogs with NFSM commonly presented with large tumors causing mass effect leading to mentation changes. Dogs that underwent TSH for a NFSM causing clinical signs of mass effect and survived to discharge had good to excellent outcomes as reported by owners.
description: Clinical significance: TSH can be considered for the treatment of NFSM causing clinical signs of mass effect in dogs. Successful long-term outcomes are possible. Adjunctive therapy may improve survival when done in conjunction with surgery.
Koldofsky: Recommended Reading List
Creators: name: Lands, Mona
name: Koldofsky, Gwendolyn
Publisher: name: Zenodo
Year: 2025

description:  .pdf scan of an 8-page, typed, annotated document, created by pianist and pedagogue Gwendolyn Kodofsky (née Williams) for her students at the University of Southern California.

This extensive literature list was offered as recommended reading for her accompaniment students and singers and includes hundreds of sources, alphabetized and categorized under the following rubric:

I. DICTIONARIES, BIBLIOGRAPHIES, INDICES

II. HISTORIES

III. SINGING & ACCOMPANYING

IV. SONG TEXTS

V. PERF0RMANCE PRACTICE

VI. BIOGRAPHIES

VII. THEMAT1C CATALOGUES

VIII. ON ENGLISH MUSIC & POETRY

IX. SELECTED EXAMPLES of SONG In HISTORICAL COLLECTIONS of MUSIC

This document offers a valuable picture of Koldofsky as a scholar, and provided the basis of bibliographies her many students later developed.

The scan is from the private collection of Koldofsky student Mona Lands, and was provided to Elvia Puccinelli and Chanda VanderHart for publication here in connection with the digital-print hybrid publication Accompaniment in America: Contextualizing Collaborative Piano (Routledge, 2025).