cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MPEC 2024-P109 : 2024 PJ2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 PJ2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
MPEC 2024-P110 : 2024 PK2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 PK2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
An air‐ and moisture‐stable zinc(II) carbene dithiolate dimer showing fast thermally activated delayed fluorescence and Dexter energy transfer catalysis
Creators: name: Mrózek, Ondřej
name: Mitra, Mousree
name: Hupp, Benjamin
name: Belyaev, Andrey
name: Lüdtke, Nora
name: Wagner, Dorothee
name: Wang, Cui
name: Wenger, Oliver S.
name: Marian, Christel M.
name: Steffen, Andreas
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: carbenes
subject: luminescence
subject: photocatalysis
subject: TADF
subject: zinc
subject: 540

description: A dimeric ZnII carbene complex featuring bridging and chelating benzene-1,2-dithiolate ligands is highly stable towards air and water. The donor-Zn-acceptor structure leads to visible light emission in the solid state, solution and polymer matrices with λmax between 577–657 nm and, for zinc(II) complexes, unusually high radiative rate constants for triplet exciton decay of up to kr=1.5×105 s−1 at room temperature. Variable temperature and DFT/MRCI studies show that a small energy gap between the 1/3LL/LMCT states of only 79 meV is responsible for efficient thermally activated delayed fluorescence (TADF). Time-resolved luminescence and transient absorption studies confirm the occurrence of long-lived, dominantly ligand-to-ligand charge transfer excited states in solution, allowing for application in Dexter energy transfer photocatalysis.
description: Chemistry - a European journal; 29(23)
Reimagining innovation pathways: exnovation and Buen Vivir as Global North–South dialogues
Creators: name: Maldonado-Mariscal, Karina
name: Hölsgens, Rick
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: exnovation
subject: Buen Vivir
subject: review paper
subject: innovation
subject: development
subject: directionality
subject: 300

description: With growing awareness of limits to growth, debates around sufficiency and new directions of innovation rise to prominence. At the same time, we witness a great divide between the Global North and South, and innovation is often seen as a decisive factor. We juxtapose two alternative approaches to innovation that place equality and sustainability centre stage. From a Global North perspective, exnovation has gained prominence. From a Global South perspective, particularly in South America, Buen Vivir calls for responsibility and nature-inclusiveness. To what extent are these perspectives changing the direction of innovation? This study is based on a systematic literature review of recent discourses on these concepts. We identified their main characteristics in four dimensions within each concept (a) technological, (b) environmental, (c) economic, and (d) social. We contextualise this analysis within theoretical debates with the aim of contributing to a better understanding of alternative concepts of innovation.
description: Journal of responsible innovation; 11(1)
title: Selling Certification of Private and Market Information
Creators: name: Celik, Gorkem
name: Strausz, Roland
Publisher: name: Hertie School
Year: 2024

description: We consider a monopolistic certifier selling certification services to a partially privately informed seller. The certifier can enable the seller to disclose her private information publicly, as well as gather additional market information about the good's quality publicly. We show that the certifier's optimal contract exhibits maximal disclosure but non-maximal information-gathering. Thus, optimal contracts eliminate private information but not market uncertainty; even though the latter would be costless, it is suboptimal as it requires excessive information rents to the seller. Thus, market inefficiencies remain due to market uncertainty but not due to private information.
description: Berlin School of Economics Discussion Papers; 45
Take A Breath: study protocol for a randomized controlled trial of an online group intervention to reduce traumatic stress in parents of children with a life threatening illness or injury
Creators: name: Rayner, M
name: Muscara, F
name: Dimovski, A
name: McCarthy, MC
name: Yamada, J
name: Anderson, VA
name: Burke, K
name: Walser, R
name: Nicholson, Jan
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4202
subject: Epidemiology
classificationCode: 4203
subject: Health services and systems
classificationCode: 5203
subject: Clinical and health psychology

description: Background: A substantial proportion of parents whose child is diagnosed with a life-threatening illness, experience high levels of distress that can lead to long-term difficulties in mental health, family functioning and child adjustment. This study evaluates the efficacy of an Acceptance Commitment Therapy-based group intervention designed to reduce distress symptoms in these parents. The program is delivered using videoconferencing to overcome factors that prevent participation in traditional face-to-face therapy. Method/design: The study is a randomized control trial of the Take A Breath group intervention for parents demonstrating elevated symptoms of acute stress, delivered via videoconferencing in six 90 min group sessions. Participants are the primary caregivers of children aged 0 to 18 years admitted for a life threatening illness or injury to the Oncology, Cardiology, Neurology or Intensive Care Departments of a tertiary pediatric hospital. Parents will be randomized to intervention or waitlist control 4-10 months after their child's diagnosis. Measures will be collected prior to and immediately post intervention for intervention and waitlist parents to assess program efficacy. Intervention parents will be followed up at 6 months to assess the maintenance of program effects. We predict that intervention parents will show fewer symptoms post intervention than waitlist parents (primary outcomes: traumatic stress, depression, anxiety, stress symptoms), reflecting improvements in the psychological skills addressed in the intervention (mediating factors). It is anticipated that reductions in mental health difficulties for intervention parents will be maintained up to 6 months post-intervention and will be associated with broader improvements in parents' adjustment, child adjustment and child wellbeing (secondary outcomes). Discussion: This study is unique in evaluating a group intervention delivered to parents of children affected by of a diverse range life-threatening illness or injury. Online communication technology is employed to reduce participation barriers. If proven efficacious, this trans-diagnostic approach offers the potential for broad use as part of the suite of psychosocial services provided to families through tertiary pediatric settings.
What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins
Creators: name: Vanderven, HA
name: Ana-Sosa-Batiz, F
name: Jegaskanda, S
name: Rockman, S
name: Laurie, K
name: Barr, I
name: Chen, Weisan
name: Wines, B
name: Hogarth, PM
name: Lambe, T
name: Gilbert, SC
name: Parsons, MS
name: Kent, SJ
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 3207
subject: Medical microbiology
classificationCode: 4202
subject: Epidemiology

description: The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well characterised for T cell immunity, but whether they also elicit functional antibodies capable of activating natural killer (NK) cells has not been explored. We studied NP and M1-specific ADCC activity using biochemical, NK cell activation and killing assays with plasma from healthy and influenza-infected subjects. Healthy adults had antibodies to M1 and NP capable of binding dimeric FcγRIIIa and activating NK cells. Natural symptomatic and experimental influenza infections resulted in a rise in antibody dependent NK cell activation post-infection to the hemagglutinin of the infecting strain, but changes in NK cell activation to M1 and NP were variable. Although antibody dependent killing of target cells infected with vaccinia viruses expressing internal influenza proteins was not detected, opsonising antibodies to NP and M1 likely contribute to an antiviral microenvironment by stimulating innate immune cells to secrete cytokines early in infection. We conclude that effector cell activating antibodies to conserved internal influenza proteins are common in healthy and influenza-infected adults. Given the significance of such antibodies in animal models of heterologous influenza infection, the definition of their importance and mechanism of action in human immunity to influenza is essential.
title: Identifying resistive open defects in embedded cells under variations
Creators: name: Najafi-Haghi, Zahra Paria
name: Wunderlich, Hans-Joachim
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 004

description: Small Delay Faults (SDFs) due to weak defects and marginalities have to be distinguished from extra delays due to process variations, since they may form a reliability threat even if the resulting timing is within the specification. In this paper, it is shown that these faults can still be identified, even if the corresponding defect cell is deeply embedded into a combinational circuit and its observability is restricted. The results of a few delay tests at different voltages and frequencies serve as the input to machine learning procedures which can classify a circuit as marginal due to defects or just slow due to variations. Several machine learning techniques are investigated and compared with respect to accuracy, precision, and recall for different circuit sizes and defect scales. The classification strategies are powerful enough to sort out defective devices without a major impact on yield.
Correlates of unequal access to preventive care in China: a multilevel analysis of national data from the 2011 China Health and Nutrition Survey
Creators: name: Huang, C
name: Liu, Chaojie
name: Pan, X-F
name: Liu, X
name: Li, N-X
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing
classificationCode: 4206
subject: Public health
classificationCode: 420602
subject: Health equity

description: Background: Preventive care has an essential role in reducing income-related health inequalities. Despite a general consensus of the need of shifting focus from disease treatment to wellness and prevention, little is known about inequalities in access to preventive care in China. Our study aimed to explore the inequalities in preventive care usage and factors that were associated with such inequalities among Chinese adults. Methods: Multilevel logistic regression analyses were performed using national data from the 2011 Chinese Health and Nutrition Survey. The study sample comprised 13,483 adults who were covered by Basic Social Medical Insurance (BSMI). We analyzed individual socioeconomic status (marital status, education attainment, annual household income per capita, and medical insurance) and contextual factors for their influence on preventive care usage (region of residence and type of community) after controlling for health needs (age, sex, and health condition). Results: Out of the participants, 6.9 % received preventive care services over the past four weeks and 3.9 % went for a general physical examination prior to the survey. We noted regional disparities in the overall use of preventive care and specific use of general physical examination, with residents from central and northeastern regions less likely to use preventive care including general physical examination than in the more affluent eastern region. Lower levels of education and income were associated with reduced use of preventive care. Subscriptions to less generous social medical insurance programs such as Urban Resident-based Medical Insurance Scheme or New Rural Cooperative Medical Scheme were associated with decreased specific use of general physical examinations, but not overall use of preventive care. Conclusions: Inequalities in preventive care usage were evident in China, and were associated with health needs and socioeconomic characteristics. Current health insurance arrangements may fail to reduce inequalities relating to preventive care. A fair and more coherent policy across all BSMI schemes is needed.
title: An interface to view collections of visual art
Creators: name: Pflüger, Hermann
name: Viehhauser, Gabriel
name: Tumanov, Rostislav
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 004
subject: 700

description: Art experts prefer being able to look at the individual images they are working on in the course of their research. However, if one were to look at digitally accessible images in the field of visual art, one would be dealing with billions of images; no one can handle visually examining such huge numbers of images one at a time. Therefore, art experts need special tools to examine and describe artworks in the context of other artworks. We used our experience from previous projects and interviews with members of the target group (art historians, curators, art dealers, and artists) to identify the central issues these experts encounter when working with large image collections and to determine the functionality and properties a system must offer to support their work. The results led to the customized interface LadeCA.View, which is now used in several projects. LadeCA.View enables experts to describe an exhibition or a collection of visual art in such a way that a user can obtain an overview of the intention, content, and structures of the exhibition or collection within a short period of time without looking at each image individually. LadeCA.View can also be used as an interface to probe more deeply into a collection or exhibition. In this paper we show the functions and visualizations of the interface and explain the design decisions. Furthermore, we outline LadeCA.View’s scope of applicability using three case studies
One great example that shows how to eliminate the gender gap in the research environment and management
Creators: name: Suchikova, Yana
Publisher: name: Zenodo
Year: 2025
Subjects: subject: gender equality
subject: research leadership
subject: academic resilience
subject: women in science
subject: Higher education
subject: structural inequality
subject: academic integrity
subject: university without walls

description: This presentation was delivered as part of the workshop "Gender dimension in research and innovation" (2nd Edition) organized by Taras Shevchenko National University of Kyiv on April 28–29, 2025.

The presentation offers a personal narrative of overcoming structural and cultural gender barriers in academic research and leadership. It reflects on the speaker’s professional path from early career challenges to becoming a university leader during wartime. Through lived experience, the presentation explores how gender bias, institutional resistance, motherhood, displacement, and war intersect in shaping academic careers.

Topics addressed include:

Gender inequality in research administration and academic hierarchies;

Balancing scientific identity with leadership roles;

Ethical dilemmas and standing up to misconduct in academia;

Resilience and institutional transformation under occupation;

The concept of a "university without walls" and the reinvention of academic systems during crisis;

Lessons learned on leadership, integrity, work–life balance, and systemic change.

The presentation combines personal storytelling with broader structural insights and is intended to inspire reflection on gendered experiences in research environments, particularly in fragile and conflict-affected contexts.
Kinesio Taping does not improve the symptoms or function of older people with knee osteoarthritis: a randomised trial
Creators: name: Wageck, B
name: Nunes, Guilherme Silva
name: Bohlen, NB
name: Santos, GM
name: De-Noronha, Marcos
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Question: Does Kinesio Taping reduce pain and swelling, and increase muscle strength, function and knee-related health status in older people with knee osteoarthritis? Design: Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessment. Participants: Seventy-six older people with knee osteoarthritis. Intervention: The experimental group received three simultaneous Kinesio Taping techniques to treat pain, strength and swelling. The control group received sham taping. All participants kept the taping on for 4 days. Outcome measures: The outcomes were: concentric muscle strength of knee extensors and flexors, measured by isokinetic dynamometry with an angular velocity of 60 deg/second normalised for body mass [(Nm/kg) x 100 (%)]; pressure pain threshold via digital pressure algometry (kgf/cm2); lower-limb swelling via volumetry (l) and perimetry (cm); physical function via the Lysholm Knee Scoring Scale (0 = worst to 100 = best); and knee-related health status via the Western Ontario and McMaster (WOMAC) osteoarthritis index (0 = best to 96 = worst). Outcomes were measured at Day 4 (end of the taping period) and Day 19 (follow-up) after the start of the treatment. Results: At Day 4, there were no significant between-group differences for knee extensor muscle strength (MD -1%, 95% CI -7 to 5), knee flexor muscle strength (MD 2%, 95% CI -3 to 7), the pressure pain threshold at any measured point, volumetry (MD 0.05 L, 95% CI -0.01 to 0.11), perimetry at any measured point, Lysholm score (MD -4 points, 95% CI -9 to 2), or WOMAC score (MD -2 points, 95% CI -8 to 4). The lack of significant between-group difference was also seen at the follow-up assessment on Day 19. Conclusion: The Kinesio Taping techniques investigated in this study provided no beneficial effects for older people with knee osteoarthritis on any of the assessed outcomes. Trial registration: Brazilian Registry of Clinical Trials, RBR-36r3t5. [Wageck B, Nunes GS, Bohlen NB, Santos GM, de Noronha M (2016) Kinesio Taping does not improve the symptoms or function of older people with knee osteoarthritis: a randomised trial. Journal of Physiotherapy 62: 153-158].
The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals
Creators: name: Tucey, TM
name: Verma-Gaur, J
name: Nguyen, J
name: Hewitt, VL
name: Lo, TL
name: Shingu-Vazquez, M
name: Robertson, AAB
name: Hill, JR
name: Pettolino, FA
name: Beddoe, Travis
name: Cooper, MA
name: Naderer, T
name: Traven, A
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3107
subject: Microbiology

description: The pathogenic yeast Candida albicans escapes macrophages by triggering NLRP3 inflammasome-dependent host cell death (pyroptosis). Pyroptosis is inflammatory and must be tightly regulated by host and microbe, but the mechanism is incompletely defined. We characterized the C. albicans endoplasmic reticulum (ER)-mitochondrion tether ERMES and show that the ERMES mmm1 mutant is severely crippled in killing macrophages despite hyphal formation and normal phagocytosis and survival. To understand dynamic inflammasome responses to Candida with high spatiotemporal resolution, we established live-cell imaging for parallel detection of inflammasome activation and pyroptosis at the single-cell level. This showed that the inflammasome response to mmm1 mutant hyphae is delayed by 10 h, after which an exacerbated activation occurs. The NLRP3 inhibitor MCC950 inhibited inflammasome activation and pyroptosis by C. albicans, including exacerbated inflammasome activation by the mmm1 mutant. At the cell biology level, inactivation of ERMES led to a rapid collapse of mitochondrial tubular morphology, slow growth and hyphal elongation at host temperature, and reduced exposed 1,3-β- glucan in hyphal populations. Our data suggest that inflammasome activation by C. albicans requires a signal threshold dependent on hyphal elongation and cell wall remodeling, which could fine-tune the response relative to the level of danger posed by C. albicans. The phenotypes of the ERMES mutant and the lack of conservation in animals suggest that ERMES is a promising antifungal drug target. Our data further indicate that NLRP3 inhibition by MCC950 could modulate C. albicansinduced inflammation.
A novel pathogenic missense variant in CNNM4 underlying Jalili syndrome: Insights from molecular dynamics simulations
Creators: name: Parveen, Asia
name: Mirza, Muhammad U.
name: Vanmeert, Michiel
name: Akhtar, Javed
name: Bashir, Hina
name: Khan, M. Zakir Saadullah
name: Shehzad, Saqib
name: Froeyen, Matheus
name: Ahmed, Wasim
name: Ansar, Muhammad
name: Wasif, Naveed
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: CBS domain
subject: CNNM4
subject: Jalili Syndrome
subject: MD Simulations
subject: Missense variant
subject: DDC 610 / Medicine & health
subject: DDC 570 / Life sciences

description: Background Jalili syndrome (JS) is a rare cone-rod dystrophy (CRD) associated with amelogenesis imperfecta (AI). The first clinical presentation of JS patients was published in 1988 by Jalili and Smith. Pathogenic mutations in the Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 4 (CNNM4) magnesium transporter protein have been reported as the leading cause of this anomaly. Methods In the present study, a clinical and genetic investigation was performed in a consanguineous family of Pakistani origin, showing characteristic features of JS. Sanger sequencing was successfully used to identify the causative variant in CNNM4. Molecular dynamics (MD) simulations were performed to study the effect of amino acid change over CNNM4 protein. Results Sequence analysis of CNNM4 revealed a novel missense variant (c.1220G>T, p.Arg407Leu) in exon-1 encoding cystathionine-β-synthase (CBS) domain. To comprehend the mutational consequences in the structure, the mutant p.Arg407Leu was modeled together with a previously reported variant (c.1484C>T, p.Thr495Ile) in the same domain. Additionally, docking analysis deciphered the binding mode of the adenosine triphosphate (ATP) cofactor. Furthermore, 60ns MD simulations were carried out on wild type (p.Arg407/p.Thr495) and mutants (p.Arg407Leu/p.Thr495Ile) to understand the structural and energetic changes in protein structure and its dynamic behavior. An evident conformational shift of ATP in the binding site was observed in simulated mutants disrupting the native ATP-binding mode. Conclusion The novel identified variant in CNNM4 is the first report from the Pakistani population. Overall, the study is valuable and may give a novel insight into metal transport in visual function and biomineralization.
Protocol for an open-label, single-arm trial of HIV pre-exposure prophylaxis (PrEP) among people at high risk of HIV infection: the NSW Demonstration Project PRELUDE
Creators: name: Vaccher, S
name: Grulich, A
name: McAllister, J
name: Templeton, DJ
name: Bloch, M
name: McNulty, A
name: Holden, J
name: Poynten, IM
name: Prestage, Garrett
name: Zablotska, I
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4206
subject: Public health
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Introduction: Despite a number of HIV prevention strategies, the number of new HIV infections remains high. In Australia, over three-quarters of new HIV diagnoses are in gay and bisexual men (GBM). Pre-exposure prophylaxis (PrEP) has been shown to be effective at preventing new HIV infections in several randomised trials. The PRELUDE study aims to evaluate the implementation of PrEP in healthcare settings in New South Wales (NSW), Australia, among a sample of high-risk adults. Methods and analysis: PRELUDE is an ongoing open-label, single-arm demonstration project, conducted in public and private clinics across NSW, Australia. Enrolment began in November 2014. The study is designed for 300 high-risk participants - mainly GBM and heterosexual women. Participants receive daily oral PrEP, composed of emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF), for up to 2.5 years. Quarterly study visits include testing for HIV and sexually transmitted infections (STIs), assessment of ongoing eligibility and side effects, and self-reported adherence. Following each study visit, online behavioural surveys are administered to collect information on medication adherence, risk behaviours and attitudes. Blood samples will be collected in a subset of patients 1, 6 and 12 months after PrEP initiation to measure FTC/TDF concentrations. Analyses using longitudinal regression models will focus on feasibility, adherence, safety, tolerability and effects of PrEP on behaviour. This study will inform PrEP policy and guide the implementation of PrEP in Australia in people at high risk of HIV. Ethics and dissemination: The study will be conducted in accordance with the Declaration of Helsinki. All patients will provide written informed consent prior to participation in the study. Publications relating to each of the primary end points will be gradually released after 12 months of follow-up is complete.
Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease
Creators: name: Passey, SL
name: Hansen, MJ
name: Bozinovski, S
name: McDonald, CF
name: Holland, Anne
name: Vlahos, R
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3208
subject: Medical physiology
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences
classificationCode: 321402
subject: Clinical pharmacology and therapeutics

description: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that constitutes a major global health burden. A significant proportion of patients experience skeletal muscle wasting and loss of strength as a comorbidity of their COPD, a condition that severely impacts on their quality of life and survival. At present, the lung pathology is considered to be largely irreversible; however, the inherent adaptability of muscle tissue offers therapeutic opportunities to tackle muscle wasting and potentially reverse or delay the progression of this aspect of the disease, to improve patients' quality of life. Muscle wasting in COPD is complex, with contributions from a number of factors including inflammatory cytokines, oxidative stress, growth and anabolic hormones, nutritional status, and physical activity. In this review, we discuss current and emerging therapeutic approaches to treat muscle wasting in COPD, including a number of pharmacological therapies that are in development for muscle atrophy in other pathological states that could be of relevance for treating muscle wasting in COPD patients.
Prevalence of Intestinal Parasites among Diarrhogenic Patients at Qilinto Prison Inmates of Addis Ababa,Ethiopia
Creators: name: Senya Asfir
Publisher: name: Zenodo
Year: 2018

description: Prevalence of Intestinal Parasites among Diarrhogenic Patients at Qilinto 

Prison Inmates of Addis Ababa,Ethiopia
Invited review: Opportunities for genetic improvement of metabolic diseases
Creators: name: Pryce, Jennie
name: Gaddis, KLP
name: Koeck, A
name: Bastin, C
name: Abdelsayed, Mary
name: Gengler, N
name: Miglior, F
name: Heringstad, B
name: Egger-Danner, C
name: Stock, KF
name: Bradley, AJ
name: Cole, JB
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3003
subject: Animal production
classificationCode: 3006
subject: Food sciences
classificationCode: 3009
subject: Veterinary sciences
subject: FOS: Veterinary sciences

description: Metabolic disorders are disturbances to one or more of the metabolic processes in dairy cattle. Dysfunction of any of these processes is associated with the manifestation of metabolic diseases or disorders. In this review, data recording, incidences, genetic parameters, predictors, and status of genetic evaluations were examined for (1) ketosis, (2) displaced abomasum, (3) milk fever, and (4) tetany, as these are the most prevalent metabolic diseases where published genetic parameters are available. The reported incidences of clinical cases of metabolic disorders are generally low (less than 10% of cows are recorded as having a metabolic disease per herd per year or parity/lactation). Heritability estimates are also low and are typically less than 5%. Genetic correlations between metabolic traits are mainly positive, indicating that selection to improve one of these diseases is likely to have a positive effect on the others. Furthermore, there may also be opportunities to select for general disease resistance in terms of metabolic stability. Although there is inconsistency in published genetic correlation estimates between milk yield and metabolic traits, selection for milk yield may be expected to lead to a deterioration in metabolic disorders. Under-recording and difficulty in diagnosing subclinical cases are among the reasons why interest is growing in using easily measurable predictors of metabolic diseases, either recorded on-farm by using sensors and milk tests or off-farm using data collected from routine milk recording. Some countries have already initiated genetic evaluations of metabolic disease traits and currently most of these use clinical observations of disease. However, there are opportunities to use clinical diseases in addition to predictor traits and genomic information to strengthen genetic evaluations for metabolic health in the future.
Variational Sequences, Representation Sequences and Applications in Physics
Creators: name: Palese, M
name: Rossi, Olga
name: Winterroth, E
name: Musilova, J
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 49
subject: Mathematical sciences
classificationCode: 4901
subject: Applied mathematics
classificationCode: 4904
subject: Pure mathematics

description: This paper is a review containing new original results on the finite order variational sequence and its different representations with emphasis on applications in the theory of variational symmetries and conservation laws in physics.
Deciphering microbial communities involved in marine steel corrosion using high throughput amplicon sequencing.supplementary file
Creators: name: Shibulal, Biji
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 410305
subject: Environmental marine biotechnology

description: To characterise the source and effects of bacterial communitiesy structure on corrosion of intertidal structures, three different UK coastal sites were sampled for corrosion materials, sediment and seawater. Chemical analyses indicate the activity of sulfate reducing microbes (SRBs) at 2 sites (Shoreham and Newhaven), but not at the third (Southend-on-Sea). Microbial communities in the deep sediment and corrosion samples are similar. The phylum Proteobacteria is dominant, (40.4% of the total ASV), followed by Campilobacterota (11.3%), Desulfobacterota and Firmicutes (4-5%). At lower taxonomic levels, corrosion causing bacteria, such as Shewanella sp. (6%), Colwellia sp. (7%), and Mariprofundus sp. (1%) are present. At Southend-on-sea the relative abundance of Campilobacterota is higher compared to the other two sites. The mechanism of action of microorganisms at Shoreham and Newhaven involves biogenic sulfuric acid corrosion of iron by the combined action of SRBs and sulfur-oxidising microbes (SOBs). However, at Southend-on-sea, sulfur compounds are not implicated in corrosion, but SRBs and other electroactive microbes may play a role in which cathodic reactions (electrical MIC) and microbial enzymes (chemical MIC) are involved. To contribute to diagnosis of accelerated intertidal corrosion types we developed a rapid identification method for SRBs using qPCR- high resolution melt curve (HRM) analysis of the dsrB gene.
Satisfaction with the outcome of physical therapist-prescribed exercise in chronic whiplash-associated disorders: secondary analysis of a randomized clinical trial
Creators: name: Ardern, Clare
name: Peterson, G
name: Ludvigsson, ML
name: Peolsson, A
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: STUDY DESIGN: Secondary analysis of a randomized clinical trial. BACKGROUND: Patient perception of the benefits gained from treatment is important, yet satisfaction with the outcome of treatment for chronic whiplash-associated disorders (WADs) has not been investigated. OBJECTIVES: To investigate whether satisfaction with the outcome of treatment for chronic WAD changed over time, and whether there were group differences. METHODS: Two hundred sixteen people with chronic WAD (66% women; mean age, 40.4 years) participated in a 3-month program of physical therapist-led neck-specific exercises with or without a behavioral approach, or received a prescription of general physical activity. The main outcome was satisfaction with the outcome of treatment, assessed at baseline and 3, 6, and 12 months later. Additional outcomes were enablement and expectation fulfillment. RESULTS: Satisfaction improved over time in the 3 groups (odds ratio = 1.15; 95% confidence interval: 1.10, 1.20; PCONCLUSION: Exercise interventions for chronic WAD led to increased satisfaction for 12 months following treatment that was unrelated to the type of exercise intervention received. LEVEL OF EVIDENCE: Therapy, level 1b. Registered January 22, 2012 at www.ClinicalTrials. gov (NCT01528579).
Germline viral "fossils" guide in silico Ereconstruction of a mid-Cenozoic era marsupial adeno-associated virus
Creators: name: Smith, RH
name: Hallwirth, CV
name: Westerman, Michael
name: Hetherington, NA
name: Tseng, Y-S
name: Cecchini, S
name: Virag, T
name: Ziegler, M-L
name: Rogozin, IB
name: Koonin, EV
name: Agbandje-McKenna, M
name: Kotin, RM
name: Alexander, IE
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3103
subject: Ecology
classificationCode: 3104
subject: Evolutionary biology
classificationCode: 3105
subject: Genetics

description: Germline endogenous viral elements (EVEs) genetically preserve viral nucleotide sequences useful to the study of viral evolution, gene mutation, and the phylogenetic relationships among host organisms. Here, we describe a lineage-specific, adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely related marsupial species. Molecular screening of a marsupial DNA panel indicated that mAAV-EVE1 occurs specifically within the marsupial suborder Macropodiformes (present-day kangaroos, wallabies, and related macropodoids), to the exclusion of other Diprotodontian lineages. Orthologous mAAV-EVE1 locus sequences from sixteen macropodoid species, representing a speciation history spanning an estimated 30 million years, facilitated compilation of an inferred ancestral sequence that recapitulates the genome of an ancient marsupial AAV that circulated among Australian metatherian fauna sometime during the late Eocene to early Oligocene. In silico gene reconstruction and molecular modelling indicate remarkable conservation of viral structure over a geologic timescale. Characterisation of AAV-EVE loci among disparate species affords insight into AAV evolution and, in the case of macropodoid species, may offer an additional genetic basis for assignment of phylogenetic relationships among the Macropodoidea. From an applied perspective, the identified AAV "fossils" provide novel capsid sequences for use in translational research and clinical applications.
Standardization of administered activities in pediatric nuclear medicine: a report of the first Nuclear Medicine Global Initiative project, part 2 - current standards and the path toward global standardization
Creators: name: Fahey, FH
name: Bom, HH-S
name: Chiti, A
name: Choi, YY
name: Huang, G
name: Lassmann, M
name: Laurin, N
name: Mut, F
name: Nunez-Miller, R
name: O'Keeffe, D
name: Pradhan, P
name: Scott, Andrew
name: Song, S
name: Soni, N
name: Uchiyama, M
name: Vargas, Lucely
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences

description: The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward global standardization of the administration of radiopharmaceuticals in children.
Altered phenotypic and functional characteristics of CD3(+)CD56(+) NKT-like cells in human gastric cancer
Creators: name: Peng, L-S
name: Mao, F-Y
name: Zhao, Y-L
name: Wang, T-T
name: Chen, N
name: Zhang, J-Y
name: Cheng, P
name: Li, W-H
name: Lv, Y-P
name: Teng, Y-S
name: Guo, G
name: Luo, P
name: Chen, Weisan
name: Zou, Q-M
name: Zhuang, Y
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 3211
subject: Oncology and carcinogenesis

description: CD3+CD56+ natural killer T (NKT)-like cells are a group of CD3+ T cells sharing characteristics of NK and T cells and constitute a major component of host antitumor immune response in human cancer. However, the nature, function and clinical relevance of CD3+CD56+ NKT-like cells in human gastric cancer (GC) remain unclear. In this study, we showed that the frequencies of CD3+CD56+NKT-like cells in GC tumors were significantly decreased and low levels of tumor-infiltrating CD3+CD56+ NKT-like cells were positively correlated with poor survival and disease progression. Most CD3+CD56+NKT-like cells in GC tumors were CD45RA-CD27+/- central/effectormemory cells with decreased activity and lower expression levels of CD69, NKG2D and DNAM-1 than those in non-tumor tissues. We further observed that tumor-infiltrating CD3+CD56+ NKT-like cells had impaired effector function as shown by decreased IFN-γ, TNF-α, granzyme B and Ki-67 expression. Moreover, in vitro studies showed that soluble factors released from GC tumors could induce the functional impairment of CD3+CD56+ NKT-like cells. Collectively, our data indicate that decreased tumorinfiltrating CD3+CD56+ NKT-like cells with impaired effector function are associated with tumor progression and poor survival of GC patients, which may contribute to immune escape of GC.
The Low Conductivity of Geobacter uraniireducens Pili Suggests a Diversity of Extracellular Electron Transfer Mechanisms in the Genus Geobacter
Creators: name: Tan, Y
name: Adhikari, RY
name: Malvankar, NS
name: Ward, JE
name: Nevin, KP
name: Woodard, TL
name: Smith, JA
name: Snoeyenbos-West, OL
name: Franks, Ashley
name: Tuominen, MT
name: Lovley, DR
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3107
subject: Microbiology
classificationCode: 3207
subject: Medical microbiology

description: Studies on the mechanisms for extracellular electron transfer in Geobacter species have primarily focused on Geobacter sulfurreducens, but the poor conservation of genes for some electron transfer components within the Geobacter genus suggests that there may be a diversity of extracellular electron transport strategies among Geobacter species. Examination of the gene sequences for PilA, the type IV pilus monomer, in Geobacter species revealed that the PilA sequence of Geobacter uraniireducens was much longer than that of G. sulfurreducens. This is of interest because it has been proposed that the relatively short PilA sequence of G. sulfurreducens is an important feature conferring conductivity to G. sulfurreducens pili. In order to investigate the properties of the G. uraniireducens pili in more detail, a strain of G. sulfurreducens that expressed pili comprised the PilA of G. uraniireducens was constructed. This strain, designated strain GUP, produced abundant pili, but generated low current densities and reduced Fe(III) very poorly. At pH 7, the conductivity of the G. uraniireducens pili was 3 × 10-4 S/cm, much lower than the previously reported 5 × 10-2 S/cm conductivity of G. sulfurreducens pili at the same pH. Consideration of the likely voltage difference across pili during Fe(III) oxide reduction suggested that G. sulfurreducens pili can readily accommodate maximum reported rates of respiration, but that G. uraniireducens pili are not sufficiently conductive to be an effective mediator of long-range electron transfer. In contrast to G. sulfurreducens and G. metallireducens, which require direct contact with Fe(III) oxides in order to reduce them, G. uraniireducens reduced Fe(III) oxides occluded within microporous beads, demonstrating that G. uraniireducens produces a soluble electron shuttle to facilitate Fe(III) oxide reduction. The results demonstrate that Geobacter species may differ substantially in their mechanisms for long-range electron transport and that it is important to have information beyond a phylogenetic affiliation in order to make conclusions about the mechanisms by which Geobacter species are transferring electrons to extracellular electron acceptors.
Prescribing Patterns in Outpatient Clinics of Township Hospitals in China: A Comparative Study before and after the 2009 Health System Reform
Creators: name: Ding, D
name: Pan, Q
name: Shan, L
name: Liu, Chaojie
name: Gao, L
name: Hao, Yanhua
name: Song, J
name: Ning, N
name: Cui, Y
name: Li, Y
name: Qi, X
name: Liang, C
name: Wu, Qunhong
name: Liu, G
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 420306
subject: Health care administration
classificationCode: 420503
subject: Community and primary care

description: Objective: China introduced a series of health reforms in 2009, including a national essential medicines policy and a medical insurance system for primary care institutions. This study aimed to determine the changing prescribing patterns associated with those reforms in township hospitals. Methods: A multi-stage stratified random cluster sampling method was adopted to identify 29 township hospitals from six counties in three provinces. A total of 2899 prescriptions were collected from the participating township hospitals using a systematic random sampling strategy. Seven prescribing indicators were calculated and compared between 2008 and 2013, assessing use of medicines (antibiotics and adrenal corticosteroids) and polypharmacy, administration route of medicines (injections), and affordability of medicines. Results: Significant changes in prescribing patterns were found. The average number of medicines and costs per-prescription dropped by about 50%. The percentage of prescriptions requiring antibiotics declined from 54% to 38%. The percentage of prescriptions requiring adrenal corticosteroid declined from 14% to 4%. The percentage of prescriptions requiring injections declined from 54% to 25%. Despite similar changing patterns, significant regional differences were observed. Conclusions: Significant changes in prescribing patterns are evident in township hospitals in China. Overprescription of antibiotics, injections and adrenal corticosteroids has been reduced. However, salient regional disparities still exist. Further studies are needed to determine potential shifts in the risk of the inappropriate use of medicines from primary care settings to metropolitan hospitals.