title: ÐÐµÑÐ²Ð¸ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð· Ð¸ Ð¸Ñ ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð³Ð¾ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾ÑÐ° Ð² Ð¾Ð±ÑÐ°Ð·ÑÐ°Ñ Ð¿ÐµÑÐ²Ð¸ÑÐ½Ð¾Ð¹ Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸ Ð¸ Ð¼ÐµÑÐ°ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ°Ð³Ð¾Ð² Ð² Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐµ Ð¿ÑÐ¾ÑÐµÑÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The primary analysis of the content of metalloproteinases and their tissue inhibitor in the sample of primary tumors and metastatic foci in a dynamic process
Creators: name: ÐÐ¸ÑÐ´ÐµÐµÐ²Ð°, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐµ Ð½Ð¾Ð²Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð·-9
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð·-14
ÑÐºÐ°Ð½ÐµÐ²ÑÐ¹ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ñ timp-4
Ð¼ÐµÐ»Ð°Ð½Ð¾Ð¼Ð° ÐºÐ¾Ð¶Ð¸
malignant neoplasms
expression of metalloproteinases-9
expression of metalloproteinases-14
tissue inhibitor timp-4
skin melanoma

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½ ÑÑÐ¾Ð²ÐµÐ½Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð· -9,-14, Ð¸ ÑÐºÐ°Ð½ÐµÐ²ÑÐ¹ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ñ TIMP-4 Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð¼ÐµÐ»Ð°Ð½Ð¾Ð¼Ñ ÐºÐ¾Ð¶Ð¸, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¾Ð¼ Ð¸ Ð¾ÑÐµÐ½ÐºÐ° ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¼ÐµÐ¶Ð´Ñ MMP-9, -14 Ð¸ TIMP-4. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐµÑÐ¼ÐµÐ½ÑÐ½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÑÐ¾Ð²Ð½Ñ MMP -9 Ð² Ð¾Ð±ÑÐ°Ð·ÑÐ°Ñ Ð¿ÐµÑÐ²Ð¸ÑÐ½Ð¾Ð¹ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð¸ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ MMP -14 Ð¸ TIMP â 4, ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾. ÐÐ¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð², Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð²ÑÐ¸Ð¹ÑÑ Ñ ÑÐµÐ»ÑÑ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð¸Ñ Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð²ÑÑÐ²Ð¸Ð» Ð½Ð°Ð»Ð¸ÑÐ¸Ðµ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð² ÑÐºÐ°Ð½ÑÑ. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¾Ð±Ð½Ð°ÑÑÐ¶Ð¸Ð» Ð¿ÑÑÐ¼ÑÑ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ñ Ð¼ÐµÐ¶Ð´Ñ MMP -14 Ð¸ TIMP â 4, ÑÐ»Ð°Ð±ÑÑ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¼ÐµÐ¶Ð´Ñ MMP-9 Ð¸ TIMP-4 Ð¸ Ð¾ÑÑÑÑÑÑÐ²Ð¸Ðµ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ð¸ Ð¼ÐµÐ¶Ð´Ñ MMP-9 Ð¸ MMP-14. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¿Ð¾ÐºÐ¾Ð»ÐµÐ½Ð¸Ñ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾ÑÐ¾Ð² Ñ ÑÐµÐ»ÑÑ ÑÑÐ¿ÐµÑÐ½Ð¾Ð³Ð¾ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¼ÐµÐ»Ð°Ð½Ð¾Ð¼Ñ Ð¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ Ð¾Ð±ÑÐµÐ³Ð¾ ÑÑÐ¾Ð²Ð½Ñ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¶Ð¸Ð·Ð½Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð².
description: In this work, we studied the level of activity of metalloproteinases -9, -14 and a tissue inhibitor of TIMP-4 in the pathogenesis of skin melanoma carried out by tumor verification, histological analysis, and the assessment of the correlation between MMP- 9, -14 and TIMP-4. According to the results of enzyme immunoassay, an increase in the level of MMP-9 in the samples of the primary tumor and a decrease in the activity of MMP-14 and TIMP-4, respectively, were established. Histological analysis of samples detected in the presence of pathological changes in tissues. Statistical analysis reveals a direct positive correlation between MMP-14 and TIMP-4, a weak relationship between MMP-9 and TIMP-4, and no correlation between MMP-9 and MMP-14. The data obtained can be used in further studies of the tumor process and the development of a new generation of inhibitors to treat melanoma and increase the overall level of patients' life expectancy.