title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ Ð½Ð° ÑÐ¿Ð¾Ð½ÑÐ°Ð½Ð½ÑÑ Ð¸ Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ñ ÐµÐ¼Ð¸Ð»ÑÐ¼Ð¸Ð½ÐµÑÑÐµÐ½ÑÐ¸Ñ ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÐºÑÐ¾Ð²Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ° Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 16.04.01 - Ð¢ÐµÑ Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ° ; 16.04.01_13 - ÐÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ°
titleType: Subtitle
Creators: name: ÐÑÑÐ¸ÑÐ¸Ð½Ð°, ÐÐ»ÑÐ³Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð°Ð´ÑÐµÑÐ½Ð°Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ° Ð»ÐµÐºÐ°ÑÑÑÐ²
Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÐµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ
Ñ ÐµÐ¼Ð¸Ð»ÑÐ¼Ð¸Ð½ÐµÑÑÐµÐ½ÑÐ¸Ñ
Ð°ÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐ¾ÑÐ¼Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð´Ð°
ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÑ

description: ÐÐ´ÑÐµÑÐ½Ð°Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ° Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÑÐµÐ´ÑÑÐ² Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ Ð² ÑÐµÑÐ°Ð¿Ð¸Ð¸ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. ÐÐ°Ð½Ð½ÑÐ¹ ÑÐ¿Ð¾ÑÐ¾Ð± Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ ÑÐ½Ð¸Ð·Ð¸ÑÑ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÐµ ÑÑÑÐµÐºÑÑ Ð¸ ÑÐ¼ÐµÐ½ÑÑÐ¸ÑÑ Ð´Ð¾Ð·Ð¸ÑÐ¾Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð². Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð¸ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ Ñ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð¸Ð· Ð°Ð»ÑÐ±ÑÐ¼Ð¸Ð½Ð°, Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´Ð° Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð°. ÐÐ°Ð³Ð½Ð¸ÑÐ½ÑÐµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ Ð¸Ð½ÐºÑÐ±Ð¸ÑÐ¾Ð²Ð°Ð»Ð¸ Ð² ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÐºÑÐ¾Ð²Ð¸ Ð¸ Ð½Ð°Ð±Ð»ÑÐ´Ð°Ð»Ð¸ ÑÐ¿Ð¾Ð½ÑÐ°Ð½Ð½ÑÑ Ð¸ Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÑÐµÐ¼Ð¸Ð»ÑÐ¼Ð¸Ð½ÐµÑÑÐµÐ½ÑÐ¸Ñ, Ð²Ð¾Ð·Ð½Ð¸ÐºÐ°ÑÑÑÑ Ð·Ð° ÑÑÐµÑ Ð¿ÑÐ¾Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÐ»ÐµÑÐºÐ°Ð¼Ð¸ ÐºÑÐ¾Ð²Ð¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ¾ÑÐ¼ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð´Ð°. ÐÐ°Ð½Ð½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¾ÑÐµÐ½Ð¸ÑÑ Ð¶Ð¸Ð·Ð½ÐµÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ ÐºÐ»ÐµÑÐ¾Ðº Ð¸, ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾, ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð½Ð° ÐºÑÐ¾Ð²Ñ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°. ÐÐ°Ð±Ð»ÑÐ´Ð°Ð»Ð¸ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐµÐ¼Ð¸Ð»ÑÐ¼Ð¸Ð½ÐµÑÑÐµÐ½ÑÐ¸Ð¸ Ð´Ð»Ñ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐ¾ Ð²ÑÐµÐ¼Ð¸ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÐ¼Ð¸ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð¿ÑÐ¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸ÑÑ 1-2 Ð¼Ð³/Ð¼Ð» Ð¸ Ñ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð¸Ð· Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´Ð° Ð¿ÑÐ¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ 0,2 Ð¼Ð³/Ð¼Ð» Ð´Ð»Ñ Ð·Ð°Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¸Ð½ÐºÑÐ±Ð°ÑÐ¸Ð¸. ÐÑÐ»Ð¸ ÑÐ´ÐµÐ»Ð°Ð½Ñ Ð²ÑÐ²Ð¾Ð´Ñ Ð¾ Ð½Ð¸Ð·ÐºÐ¾Ð¹ ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ Ñ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð¸Ð· Ð°Ð»ÑÐ±ÑÐ¼Ð¸Ð½Ð° Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð° Ð² ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ 0,2 Ð¼Ð³/Ð¼Ð».
description: Targeted drug delivery using magnetic nanoparticles is a promising direction in the treatment of various diseases. This method allows to reduce side effects and reduce dosages of drugs. In this paper, we studied the properties of magnetic nanoparticles with shells of albumin, polylactide, and polysaccharide. Magnetic nanoparticles were incubated in whole blood, and spontaneous and induced chemiluminescence, resulting from the production of reactive oxygen species by blood cells, was observed. This method allows to evaluate cell viability and, accordingly, the toxic effects of magnetic nanoparticles with different shells on human blood. A decrease in the chemiluminescence intensity was observed for magnetic nanoparticles with all the studied shells at concentrations of 1-2 mg/ml and with polylactide shells at a concentration of 0.2 mg/ml for the given incubation parameters. Conclusions were drawn about the low toxicity of magnetic nanoparticles with albumin and polysaccharide shells at a concentration of 0.2 mg/ml.