cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Fetus radiation protection: a biliary fluoroscopy procedure in a four months pregnant liver transplanted woman
Creators: name: Gerasia, Roberta
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 7 - Radiation protection of children
subject: Biliary Tract / Gallbladder
subject: Interventional non-vascular
subject: Liver
subject: Fluoroscopy
subject: Dosimetry
subject: Equipment
subject: Radiation safety
subject: Foetus
subject: Not applicable
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The various potential transplant-related complications make pregnancy more risky than in the general population for both the mother and the fetus [1]. In addition, in situations in which an interventional procedure is deemed clinically necessary...
Exploratory multinomial logit model–based driver injury severity analyses for teenage and adult drivers in intersection-related crashes
Creators: name: Wu, Qiong
name: Zhang, Guohui
name: Ci, Yusheng
name: Wu, Lina
name: A. Tarefder, Rafiqul
name: “Dely” Alcántara, Adélamar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: Objective: Teenage drivers are more likely to be involved in severely incapacitating and fatal crashes compared to adult drivers. Moreover, because two thirds of urban vehicle miles traveled are on signal-controlled roadways, significant research efforts are needed to investigate intersection-related teenage driver injury severities and their contributing factors in terms of driver behavior, vehicle–infrastructure interactions, environmental characteristics, roadway geometric features, and traffic compositions. Therefore, this study aims to explore the characteristic differences between teenage and adult drivers in intersection-related crashes, identify the significant contributing attributes, and analyze their impacts on driver injury severities. Methods: Using crash data collected in New Mexico from 2010 to 2011, 2 multinomial logit regression models were developed to analyze injury severities for teenage and adult drivers, respectively. Elasticity analyses and transferability tests were conducted to better understand the quantitative impacts of these factors and the teenage driver injury severity model's generality. Results: The results showed that although many of the same contributing factors were found to be significant in the both teenage and adult driver models, certain different attributes must be distinguished to specifically develop effective safety solutions for the 2 driver groups. Conclusions: The research findings are helpful to better understand teenage crash uniqueness and develop cost-effective solutions to reduce intersection-related teenage injury severities and facilitate driver injury mitigation research.
title: The use of dose monitoring software in fluoroscopy guided pediatric procedures performed with a low-dose autoexposition trajectory
Creators: name: Gerasia, Roberta
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 4 - Dose management systems
subject: Biliary Tract / Gallbladder
subject: Interventional vascular
subject: Liver
subject: Fluoroscopy
subject: Dosimetry
subject: Radiation safety
subject: Education and training
subject: Retrospective
subject: Observational
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The EURATOM 2013/59 suggest that any equipment used for interventional radiology has a device informing the practitioner and those carrying out practical aspects of the medical procedures of quantity of radiation produced by the equipment during the...
Developing Airline Segmentation Based on The On-time Performance
Creators: name: SciDoc Publishers
name: Dothang Truong
Publisher: name: figshare
Year: 2017
Subjects: Astrophysics

description: Flight delay is a critical nation wide issue that has negative impacts on both airlines and passengers. However, airlines do not perform equally in term of on-time arrival rates. The purpose of this paper is to develop airline segmentation in the market based on the on-time performance. Cluster analysis was performed using flight delay data collected from the Bureau of Transportation Statistics (BTS) databases. The results indicate three major segments in the airline market based on similarities among airlines in regard to their on-time performance. The differences of on-time performance across these segments and the airline profile of each segment provide airlines and passengers useful information to make meaningful decisions.
title: Image quality and dose evaluation in Whole-Body Low-Dose Computed Tomography (WBLDCT) in patients with multiple myeloma and related plasma cell dyscrasias
Creators: name: Franchi, Marta
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Observational
subject: Retrospective
subject: Dosimetric comparison
subject: Radiation safety
subject: Dosimetry
subject: CT
subject: Radioprotection / Radiation dose
subject: Oncology
subject: Haematologic
subject: Physics in Medical Imaging

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Compared with whole-body X-ray, WBLDCT has shown a higher sensitivity and diagnostic capacity for detection of osteolitic lesions in multiple myeloma. The aim of this study is to estimate the effective dose associated with WBLDCT, while preserving a...
Emotion recognition and theory of mind in schizophrenia: A meta-analysis of neuroimaging studies
Creators: name: Jáni, Martin
name: Tomáš Kašpárek
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Patients with schizophrenia have difficulties processing the emotional and cognitive states of others. Neuroimaging studies show inconsistent findings. Methods: We used a Seed-based d Mapping meta-analytic method to explore brain activation during facial emotion recognition and theory of mind tasks in schizophrenia patients. Results: The patients showed lesser recruitment of the facial emotion processing network; behavioural performance was associated with the activation of the precentral gyrus. We found abnormal activation of the mentalising network in schizophrenia patients during reasoning about other people’s mental states; patients with worse performances showed lesser activation in the right insula and superior temporal gyrus. Multimodal meta-analysis showed overlaps of brain-related abnormalities for both modalities in schizophrenia, with reduced recruitment of the right insula, anterior cingulate and medial prefrontal cortex and increased activation in the bilateral parietal cortex. Meta-regression results indicate that illness duration, medication and symptomatology might influence social-cognitive network disruptions in schizophrenia. Conclusions: These findings suggest the complex impairment of social cognition, as demonstrated by neural-related circuit disruptions during facial emotion processing and theory of mind tasks in schizophrenia.
Exploratory Multinomial Logit Model-based Driver Injury Severity Analyses for Teenage and Adult Drivers in Intersection-Related Crashes
Creators: name: Wu, Qiong
name: Zhang, Guohui
name: Ci, Yusheng
name: Wu, Lina
name: A. Tarefder, Rafiqul
name: “Dely” Alcántara, Adélamar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology

description: Objective: Teenage drivers are more likely to be involved in severely incapacitating and fatal crashes compared to adult drivers. Moreover, since two-thirds of urban Vehicle Miles Traveled (VMTs) are on signal controlled roadways, significant research efforts are needed to investigate intersection-related teenage driver injury severities and their contributing factors in terms of driver behavior, vehicle-infrastructure interactions, environmental characteristics, roadway geometric features, and traffic compositions. Therefore, this study aims to explore the characteristic differences between teenage and adult drivers in intersection-related crashes, identify the significant contributing attributes and analyze their impacts on driver injury severities.Methods: Using crash data collected in New Mexico from 2010 to 2011, two multinomial Logit regression models were developed to analyze injury severities for teenage and adult drivers, respectively. Elasticity analyses and transferability tests were conducted to better understand the quantitative impacts of these factors and the teenage driver injury severity model's generality.Results: The results showed that although many of the same contributing factors were found to be significant in the both teenage and adult driver models, certain different attributes must be distinguished to specifically develop effective safety solutions for two driver groups.Conclusions: The research findings are helpful to better understand teenage crash uniqueness and develop cost-effective solutions to reduce intersection-related teenage injury severities and facilitate driver injury-mitigation research.
title: The Journey to CT Dose Optimization
Creators: name: Burton, Corwin
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Not applicable
subject: Not applicable
subject: Education and training
subject: Radiation safety
subject: CT
subject: Radioprotection / Radiation dose
subject: Management
subject: Radiographers

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Continuous quality improvement should be aconstantjourney in every medical imaging department and organization. Through this journey we can continually ignite change and create a growing culture of quality and safety. Our journey started in 2013...
Global health resource utilization associated with pacemaker complications
Creators: name: Waweru, Catherine
name: Steenrod, Anna
name: Wolff, Claudia
name: Eggington, Simon
name: Wright, David Jay
name: Wyrwich, Kathleen W.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Aim: To estimate health resource utilization (HRU) associated with the management of pacemaker complications in various healthcare systems. Methods: Electrophysiologists (EPs) from four geographical regions (Western Europe, Australia, Japan, and North America) were invited to participate. Survey questions focused on HRU in the management of three chronic pacemaker complications (i.e. pacemaker infections requiring extraction, lead fractures/insulation breaches requiring replacement, and upper extremity deep venous thrombosis [DVT]). Panelists completed a maximum of two web-based surveys (iterative rounds). Mean, median values, and interquartile ranges were calculated and used to establish consensus. Results: Overall, 32 and 29 panelists participated in the first and second rounds of the Delphi panel, respectively. Consensus was reached on treatment and HRU associated with a typical pacemaker implantation and complications. HRU was similar across regions, except for Japan, where panelists reported the longest duration of hospital stay in all scenarios. Infections were the most resource-intensive complications and were characterized by intravenous antibiotics days of 9.6?13.5 days and 21.3?29.2 days for pocket and lead infections respectively; laboratory and diagnostic tests, and system extraction and replacement procedures. DVT, on the other hand, was the least resource intensive complication. Limitations: The results of the panel represent the views of the respondents who participated and may not be generalizable outside of this panel. The surveys were limited in scope and, therefore, did not include questions on management of acute complications (e.g. hematoma, pneumothorax). Conclusions: The Delphi technique provided a reliable and efficient approach to estimating resource utilization associated with chronic pacemaker complications. Estimates from the Delphi panel can be used to generate costs of pacemaker complications in various regions.
Mass spectrometry-guided isolation of two new benzoquinoline alkaloids from Macleaya cordata
Creators: name: Qing, Zhi-Xing
name: Xu, Yu-Qin
name: Yang, Peng
name: Yu, Kun
name: Cheng, Pi
name: Zeng, Jian-Guo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Two new alkaloids, named 2,3-methylenedioxy-7,10-dimethyl-7,8,9,10-tetrahydro-benzoquinoline (1) and 2,3-methylenedioxy-7,10-dimethyl-8-carboxyl-benzoquinoline (2), were detected primarily from the fruits of Macleaya cordata by their different fragmentation pathways. And then isolation of the two compounds was performed by column chromatography and preparative HPLC under the guiding of mass spectrometry. Finally, their structures were determined by spectroscopic analysis.
title: Dose optimisation of head computed tomography in paediatric patients (< 1 year)
Creators: name: Habib Geryes, Bouchra
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Retrospective
subject: Image verification
subject: Dosimetric comparison
subject: Radiation safety
subject: Dosimetry
subject: CT-Angiography
subject: CT
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Head and neck
subject: Action 7 - Radiation protection of children

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The associated risk of ionizing radiation must be considered carefully when CT is performed on children due to their higher sensitivity to radiation damage and long life expectancy [1]. Therefore, it is mandatory to respect the radiation protection...
title: Материалы научной конференции с международным участием "Неделя науки СПбПУ", 18–23 ноября 2019 года. Инженерно-строительный институт. В 3 ч. Ч. 2
Creators: name: Научная конференция с международным участием "Неделя науки СПбПУ" (2019; Санкт-Петербург)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019

description: В сборник включены статьи студентов, аспирантов, молодых ученых и сотрудников СПбПУ, университетов, научных организаций и предприятий Санкт-Петербурга, России, зарубежных стран по материалам докладов, принятых на секционные заседания конференции «Неделя науки СПбПУ» Инженерно-строительного института. Статьи отражают современный уровень научно-исследовательской работы участников конференции в области строительства. Представляют интерес для специалистов в различных областях знаний, учащихся и работников системы высшего образования и Российской академии наук.
Assessing the Trade-off between Outreach and Financial Sustainability of the Microfinance Industry in the MENA Region
Creators: name: El.Azzazy, Lamiaa
Publisher: name: Cardiff Metropolitan University
Year: 2024
Subjects: classificationCode: 350202
subject: Finance
classificationCode: 350209
subject: Not-for-profit finance and risk

description: In the Middle East and North Africa (MENA) region, the reduction of poverty remains one of the most critical Sustainable Development Goals yet to be achieved. The region has experienced several shocks over the last decade. This has led to high unemployment particularly among young people  and females, and this has affected both poverty levels and human well-being. Access to financial services plays a vital role in eliminating poverty in the region. One of the main tools to  improve financial inclusion in the region is Microfinance (MF). However, for microfinance intuitions (MFIs) to meet the demands of the market, they need to  focus on achieving ‘The Microfinance Dual mission’; outreach to the poor, and financial sustainability. The complementary role of social outreach and  financial sustainability is highly promising for both welfarists who strive to employ MFIs to alleviate poverty and institutionalists who advocate for attaining financial sustainability. This study assesses whether there is a trade-off between financial sustainability and outreach to the poor in MFIs in the MENA region.  
In assessing the simultaneous relationships that exist between outreach and financial sustainability, the GMM estimator was used with balanced panel data consisting of sample of 20 MFIs from 10 countries in the MENA region; a total of 300 observations over the period between 2004 and 2018. The study examines the simultaneous relationships that exist between  two endogeneity variables: Sustainability variable measured by (ROA and OSS), and outreach  variable measured by average loan balance per borrower/ GNI per capita, number of active borrowers, and proportion of women borrowers. The findings show that; a) Increases in sustainability are positively associated with greater breadth of outreach, b) increases in sustainability result in a decrease in average loan balance per borrower; implying a  better depth of outreach. The study finds no evidence of  a trade-off. The thesis advances a better understanding of the Microfinance dual mission and contributes to addressing an existing gap in knowledge by building a more comprehensive model that could guide policymakers in the microfinance sector with regard to attaining better social outreach and financial inclusion.
title: Experiences in Establishing and implementing clinical DRLs - The Swiss experience
Creators: name: Ott, Barbara
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: CT
subject: Cone beam CT
subject: Radiation effects
subject: Physics
subject: Dosimetric comparison
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Radioprotection / Radiation dose
subject: Radiation physics

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Success of a diagnostic radiology examination does not only depend on dose optimization but even more on the appropriate image quality in order to answer the clinical question. Not every clinical question, even if it concerns the same anatomical...
Hepatoprotective iridoid glucosides from Callicarpa nudiflora
Creators: name: Luo, Yue-Hua
name: Fu, Hui-Zheng
name: Huang, Bo
name: Chen, Wei-Kang
name: Ma, Shuang-Cheng
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biochemistry
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Two new iridoid glucosides, callicoside A (1) and callicoside B (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by means of spectroscopic methods and chemical evidences. In an in vitro bioassay, compound 1 showed pronounced hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
Investigation of the phosphorus removal capacities of basic oxygen furnace slag under variable conditions
Creators: name: Han, Chong
name: Wang, Zhen
name: Yang, Wangjin
name: Wu, Qianqian
name: Yang, He
name: Xue, Xiangxin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Effects of reaction time, initial phosphorus concentration, basic oxygen furnace slag (BOF-slag) dosage and size, and temperature on the phosphorus removal capacities (PRCs) of BOF-slag have been investigated in detail through batch tests. Weakly bound phosphorus, Fe- and Al-associated phosphorus, and Ca-associated phosphorus from fresh and reacted BOF-slag were analysed using sequential chemical extraction processes. It was determined that the PRCs of BOF-slag increased with the increase of initial phosphorus concentration and temperature while it decreased with the increase of BOF-slag dosage and size. The phosphorus removed by BOF-slag was primarily assigned to weakly bound phosphorus and Ca-associated phosphorus. Weakly bound phosphorus showed a significant decrease with the increase in all experimental parameter values. However, Ca-associated phosphorus exhibited a prominent increase with increasing reaction time, initial phosphorus concentration, and temperature. These demonstrate that experimental parameters can simultaneously affect the PRCs of BOF-slag and the ways of phosphorus removal by BOF-slag.
title: PNS DIGITAL TOMOSYNTHESIS: A cost-effective and low-dose imaging STRATEGY
Creators: name: Kala, Prachi
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Ear / Nose / Throat
subject: Radioprotection / Radiation dose
subject: Digital radiography
subject: Diagnostic procedure
subject: Dosimetric comparison
subject: Prospective
subject: Cross-sectional study
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Before the invention of advanced technologies, conventional radiogram (Caldwell or Water's views) was considered to evaluate Para Nasal Sinus (PNS). However, simple radiogram has poor sensitivity and specificity in demonstrating anatomy and in...
Emotion recognition and theory of mind in schizophrenia: a meta-analysis of neuroimaging studies
Creators: name: Jáni, Martin
name: Tomáš Kašpárek
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Introduction: Patients with schizophrenia have difficulties processing the emotional and cognitive states of others. Neuroimaging studies show inconsistent findings. Method: We used a seed-based d mapping meta-analytic method to explore brain activation during facial emotion recognition and theory of mind tasks in schizophrenia patients. Results: The patients showed lesser recruitment of the facial emotion processing network; behavioural performance was associated with the activation of the precentral gyrus. We found abnormal activation of the mentalising network in schizophrenia patients during reasoning about other people’s mental states; patients with worse performances showed lesser activation in the right insula and superior temporal gyrus. Multimodal meta-analysis showed overlaps of brain-related abnormalities for both modalities in schizophrenia, with reduced recruitment of the right insula, anterior cingulate, and medial prefrontal cortex and increased activation in the bilateral parietal cortex. Meta-regression results indicate that illness duration, medication, and symptomatology might influence social-cognitive network disruptions in schizophrenia. Conclusion: These findings suggest the complex impairment of social cognition, as demonstrated by neural-related circuit disruptions during facial emotion processing and theory of mind tasks in schizophrenia.
Investigation of the phosphorus removal capacities of basic oxygen furnace slag under variable conditions
Creators: name: Han, Chong
name: Wang, Zhen
name: Yang, Wangjin
name: Wu, Qianqian
name: Yang, He
name: Xue, Xiangxin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Medicine
subject: Physics
subject: Biochemistry

description: Effects of reaction time, initial phosphorus concentration, BOF-slag dosage and size, and temperature on the phosphorus removal capacities (PRCs) of basic oxygen furnace slag (BOF-slag) have been investigated in detail through batch tests. Weakly bound phosphorus, Fe and Al associated phosphorus, and Ca associated phosphorus from fresh and reacted BOF-slag were analyzed using sequential chemical extraction processes. It was determined that the PRCs of BOF-slag increased with the increase of initial phosphorus concentration and temperature while it decreased with the increase of BOF-slag dosage and size. The removed phosphorus by BOF-slag was primarily assigned to weakly bound phosphorus and Ca associated phosphorus. Weakly bound phosphorus showed a significant decrease with increasing all of experimental parameter values. However, Ca associated phosphorus exhibited a prominent increase with increasing reaction time, initial phosphorus concentration, and temperature. These demonstrate that experimental parameters can simultaneously affect the PRCs of BOF-slag and the ways of phosphorus removal by BOF-slag.
title: EFSUMB paediatric CEUS registry: a platform towards the documentation of safety and benefit of CEUS in children ultimately reducing radiation.
Creators: name: Rafailidis, Vasileios
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 7 - Radiation protection of children
subject: Contrast agents
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Tissue characterisation
subject: Transplantation
subject: Trauma
subject: Retrospective
subject: Observational
subject: Multicentre study

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Ultrasound (US) is undoubtedly a crucial modality for paediatric Radiology, with inherent advantages including lack of ionizing radiation, good patient tolerability and widespread availability. Nevertheless, there are clinical settings where it...
A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze
Creators: name: Zeng, Biao
name: Liu, Guang-Da
name: Zhang, Bao-Bao
name: Wang, Shan-shan
name: Ma, Rui
name: Zhong, Bei-Shan
name: He, Bai-qiu
name: Liang, Yan
name: Wu, Fei-Hua
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: A new triterpene saponin, 3β,16β,23α,28β,30β-pentahydroxyl-olean-11,13(18)-dien-3β-yl-[β-d-glucopyranosyl-(1→2)]-[β-d-glucopyranosyl-(1→3)]-β-d-fucopyranoside, was named Clinoposaponin D (1), together with six known triterpene saponins, buddlejasaponin IVb (2), buddlejasaponin IVa (3), buddlejasaponin IV (4), clinopodisides D (5), 11α,16β,23,28-Tetrahydroxyolean-12-en-3β-yl-[β-d-glucopyranosyl-(1→2)]-[β-d-glucopyranosyl-(1→3)]-β-d-fucopyranoside (6) and prosaikogenin A (7), and two known triterpenes, saikogenin A (8) and saikogenin F (9) were isolated from Clinopodium chinense (Benth.) O. Kuntze. Their structures were elucidated on the basis of 1D, 2D NMR and MS analysis. Meanwhile, the effects of all compounds on rabbit platelet aggregation and thrombin time (TT) were investigated in vitro. Compounds 4 and 7 had significant promoting effects on platelet aggregation with EC50 value at 53.4 and 12.2 μM, respectively. In addition, the highest concentration (200 μM) of compounds 2 and 9 shortened TT by 20.6 and 25.1%, respectively.
Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice
Creators: name: Chen, Ying
name: Zhang, Chang
name: Jin, Mei-Na
name: Qin, Nan
name: Qiao, Wei
name: Yue, Xiao-Long
name: Duan, Hong-Quan
name: Niu, Wen-Yan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Computational Biology

description: In our previous study, a derivative of tiliroside, 3-O-[(E)-4-(4-ethoxyphenyl)-2-oxobut-3-en-1-yl]kaempferol (Fla-OEt) significantly enhanced glucose consumption in insulin resistant HepG2 cells. This article deals with the antihyperglycemic and antihyperlipidemic effects of Fla-OEt in diet-induced obesity (DIO) mice. Daily administration of Fla-OEt significantly decreased oral glucose tolerance test, intraperitoneal insulin tolerance test and serum lipids. Hyperinsulinemic–euglycemic clamp and the ratio of high-density-lipoprotein/low-density-lipoprotein with Fla-OEt treatment were increased comparing with high-fat diet (HFD) group, so lipid metabolism was improved. Histopathology examination showed that the Fla-OEt restored the damage of adipose tissues and liver in DIO mice. Moreover, compared with HFD group, Fla-OEt treatment significantly increased the phosphorylation of AMPK and ACC in adiposity tissues, liver, and muscles. The mechanism of its action might be the activation of AMPK pathway. It appears that Fla-OEt is worth further study for development as a lead compound for a potential antidiabetic agent.
Structure-based approach for the study of thyroid hormone receptor binding affinity and subtype selectivity
Creators: name: Wang, Fang-Fang
name: Yang, Wei
name: Shi, Yong-Hui
name: Cheng, Xiang-Rong
name: Le, Guo-Wei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biophysics
Biochemistry
Medicine
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Thyroid hormone (TH) possesses the ability to lower cholesterol and improve cardiac performance, which have prompted the efforts to design analogs that can utilize the cholesterol-lowering property without adversely affecting heart function. In order to gain insights into the interaction mechanism for agonists at the active site of thyroid hormone receptor β (TRβ), quantitative structure–activity relationship (QSAR) models have been developed on TRβ agonists, significant statistical coefficients were obtained (CoMFA, R2cv, .732), (CoMSIA, R2cv, .853), indicating the internal consistency of the models, the obtained models were further validated using the test set, the acquired R2pred values .7054 and .7129 were in good agreement with the experimental results. The key amino acids affecting ligand binding were identified by molecular docking, and the detailed binding modes of the compounds with different activities were also determined. Furthermore, molecular dynamics (MD) simulations were conducted to assess the reliability of the derived models and the docking results. Moreover, TH exerts significant physiological effects through modulation of the two human thyroid hormone receptor subtypes. Because TRβ and TRα locate in different target cells, selective TR ligands would target specific tissues regulated by one receptor without affecting the other. Thus, the 3D information was analyzed to reveal the most relevant structural features involved in selectivity. The findings serve as the basis for further investigation into selective TRβ/TRα agonists.
Structure-Based Approach for the Study of Thyroid Hormone Receptor Binding Affinity and Subtype Selectivity
Creators: name: Wang, Fang-fang
name: Yang, Wei
name: Shi, Yong-Hui
name: Cheng, Xiang-Rong
name: Le, Guo-Wei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Pharmacology
Molecular Biology
Cell Biology
Medicine
Biochemistry

description: : Thyroid hormone possesses the ability to lower cholesterol and improve cardiac performance, which have prompted the efforts to design analogs that can utilize the cholesterol-lowering property without adversely affecting heart function. In order to gain insights into the interaction mechanism for agonists at the active site of thyroid hormone receptor β (TRβ), quantitative structure-activity relationship (QSAR) models have been developed on TRβ agonists, significant statistical coefficients were obtained (CoMFA, R2cv, 0.732), (CoMSIA, R2cv, 0.853), indicating the internal consistency of the models, the obtained models were further validated using the test set, the acquired R2pred values 0.7054 and 0.7129 were in good agreement with the experimental results. The key amino acids affecting ligand binding were identified by molecular docking, and the detailed binding modes of the compounds with different activities were also determined. Furthermore, molecular dynamics (MD) simulations were conducted to assess the reliability of the derived models and the docking results. Moreover, thyroid hormones (TH) exerts significant physiological effects through modulation of the two human thyroid hormone receptor subtypes. Because TRβ and TRα locate in different target cells, selective TR ligands would target specific tissues regulated by one receptor without affecting the other. Thus, the 3D information was analyzed to reveal the most relevant structural features involved in selectivity. The findings serve as the basis for further investigation into selective TRβ/TRα agonists.
Structure and age-dependent development of the turkey liver: a comparative study of a highly selected meat-type and a wild-type turkey line
Creators: name: Hünigen, Hana
name: Mainzer, Kathleen
name: Hirschberg, Ruth M.
name: Custodis, Pia
name: Gemeinhardt, Ole
name: Masri, Salah Al
name: Richardson, Kenneth C.
name: Hafez, Hafez Mohamed
name: Plendl, Johanna
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: liver
subject: morphology
subject: wild turkey line
subject: BUT Big 6
subject: lymphatic aggregation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
subject: 500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::590 Tiere (Zoologie)

description: In this study the macroscopic and microscopic structure of the liver of a fast growing, meat-type turkey line (British United turkeys BUT Big 6, n = 25) and a wild-type turkey line (Wild Canadian turkey, n = 48) were compared at the age of 4, 8, 12, 16, and 20 wk. Because the growth plates of long bones were still detectable in the 20-week-old wild-type turkeys, indicating immaturity, a group of 8 wild-type turkeys at the age of 24 wk was included in the original scope of the study. Over the term of the study, the body and liver weights of birds from the meat-type turkey line increased at a faster rate than those of the wild-type turkey line. However, the relative liver weight of the meat-type turkeys declined (from 2.7 to 0.9%) to a greater extent than that of the wild-type turkeys (from 2.8 to 1.9%), suggesting a mismatch in development between muscle weights and liver weights of the meat-type turkeys. Signs of high levels of fat storage in the liver were detected in both lines but were greater in the wild-type turkey line, suggesting a better feed conversion by the extreme-genotype birds i.e., meat-type birds. For the first time, this study presents morphologic data on the structure and arrangement of the lymphatic tissue within the healthy turkey liver, describing two different types of lymphatic aggregations within the liver parenchyma, i.e., aggregations with and without fibrous capsules. Despite differences during development, both adult meat-type and adult wild-type turkeys had similar numbers of lymphatic aggregations.
title: A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress
Creators: name: Omidbakhshfard, Mohammad Amin
name: Sujeeth, Neerakkal
name: Gupta, Saurabh
name: Omranian, Nooshin
name: Guinan, Kieran J.
name: Brotman, Yariv
name: Nikoloski, Zoran
name: Fernie, Alisdair R.
name: Mueller-Roeber, Bernd
name: Gechev, Tsanko S.
Publisher: name: Universität Potsdam
Year: 2020

description: Abiotic stresses cause oxidative damage in plants. Here, we demonstrate that foliar application of an extract from the seaweed Ascophyllum nodosum, SuperFifty (SF), largely prevents paraquat (PQ)-induced oxidative stress in Arabidopsis thaliana. While PQ-stressed plants develop necrotic lesions, plants pre-treated with SF (i.e., primed plants) were unaffected by PQ. Transcriptome analysis revealed induction of reactive oxygen species (ROS) marker genes, genes involved in ROS-induced programmed cell death, and autophagy-related genes after PQ treatment. These changes did not occur in PQ-stressed plants primed with SF. In contrast, upregulation of several carbohydrate metabolism genes, growth, and hormone signaling as well as antioxidant-related genes were specific to SF-primed plants. Metabolomic analyses revealed accumulation of the stress-protective metabolite maltose and the tricarboxylic acid cycle intermediates fumarate and malate in SF-primed plants. Lipidome analysis indicated that those lipids associated with oxidative stress-induced cell death and chloroplast degradation, such as triacylglycerols (TAGs), declined upon SF priming. Our study demonstrated that SF confers tolerance to PQ-induced oxidative stress in A. thaliana, an effect achieved by modulating a range of processes at the transcriptomic, metabolic, and lipid levels.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 823
Polyamide thin-film composite membrane based on nano-silica modified polysulfone microporous support layer for forward osmosis
Creators: name: Huang, Yangbo
name: Jin, Haiyang
name: Yu, Ping
name: Luo, Yunbai
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: In this study, polyamide thin-film nanocomposite (TFN) membranes were prepared on nanosilica-modified polysulfone (PSf) support layers for forward osmosis (FO) applications. Different contents of SiO2 nanoparticles (1, 3, and 5 wt%) were added to a dope solution to develop FO membranes with improved performance. The effects of SiO2 on the membranes were investigated by attenuated total reflectance-Fourier transform infrared spectrometry, scanning electron microscope, hydrophilicity measurement, and mechanical property tests. The results showed that the wettability of PSf substrates was improved with increasing concentrations of SiO2. The resulting TFN membranes had smaller structural parameters, which meant lower internal concentration polarization effects compared to typical thin-film composite membranes. However, SiO2 nanoparticle is a good modifying agent to enhance water permeability, but it could not improve the selectivity of TFN membranes. The FO performance was evaluated using deionized water as feed solution and either 1 or 2 M NaCl as draw solution in both membrane orientations. The FO water flux of the fabricated membranes increased from 9.1 to 22.3 LMH when the active layer faced the feed solution (AL-FS) and 18.2 to 41.9 LMH when the active layer was placed towards the draw solution (AL-DS), mainly due to the improvement of PSf substrate with an addition of SiO2.
title: Optimization and dose reduction in paediatric CT: experience from Estonian teaching hospital
Creators: name: Langemets, Kristiina
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Not applicable
subject: Prospective
subject: Quality assurance
subject: Education and training
subject: Statistics
subject: FOS: Mathematics
subject: MR
subject: CT
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Action 7 - Radiation protection of children
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Results from the Nordic-Baltic Paediatric Computed Tompgraphy (CT) dose survey (2011) suggested the potential of optimizing paediatric CT usage in Tartu University Hospital [1]. A subsequent review of practice in our hospital revealed that the...
Structure-based rational design of peptide hydroxamic acid inhibitors to target tumor necrosis factor-α converting enzyme as potential therapeutics for hepatitis
Creators: name: Wu, Dan
name: Gu, Qiuhong
name: Zhao, Ning
name: Xia, Fei
name: Li, Zhiwei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: The human tumor necrosis factor-α converting enzyme (TACE) has recently been raised as a new and promising therapeutic target of hepatitis and other inflammatory diseases. Here, we reported a successful application of the solved crystal structure of TACE complex with a peptide-like ligand INN for rational design of novel peptide hydroxamic acid inhibitors with high potency and selectivity to target and inhibit TACE. First, the intermolecular interactions between TACE catalytic domain and INN were characterized through an integrated bioinformatics approach, with which the key substructures of INN that dominate ligand binding were identified. Subsequently, the INN molecular structure was simplified to a chemical sketch of peptide hydroxamic acid compound, which can be regarded as a linear tripeptide capped by a N-terminal carboxybenzyl group (chemically protective group) and a C-terminal hydroxamate moiety (coordinated to the Zn2+ at TACE active site). Based on the sketch, a virtual combinatorial library containing 180 peptide hydroxamic acids was generated, from which seven samples were identified as promising candidates by using a knowledge-based protein–peptide affinity predictor and were then tested in vitro with a standard TACE activity assay protocol. Consequently, three designed peptide hydroxamic acids, i.e. Cbz-Pro-Ile-Gln-hydroxamic acid, Cbz-Leu-Ile-Val-hydroxamic acid and Cbz-Phe-Val-Met-hydroxamic acid, exhibited moderate or high inhibitory activity against TACE, with inhibition constants Ki of 36 ± 5, 510 ± 46 and 320 ± 26 nM, respectively. We also examined the structural basis and non-bonded profile of TACE interaction with a designed peptide hydroxamic acid inhibitor, and found that the inhibitor ligand is tightly buried in the active pocket of TACE, forming a number of hydrogen bonds, hydrophobic forces and van der Waals contacts at the interaction interface, conferring both stability and specificity for TACE–inhibitor complex architecture.
title: Uptake of Esperanto, the ESR audit guide, and the current status of clinical audit within the Eurosafe Imaging Stars Network: Result from a Feedback Survey.
Creators: name: Mahmood, Nadia
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Not applicable
subject: Not applicable
subject: Quality assurance
subject: Education and training
subject: Radiation safety
subject: Education
subject: Digital radiography
subject: CT
subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: Action 10 - EuroSafe Imaging Stars

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The European Council Basic Safety Standards Directive (BSSD) 2013/59 Euratomdetails updated legal requirements for radiation protection in departments across Europe. This was transposed in 2018. Compliance with BSSD is now not only good medical...
Does ligand–receptor mediated competitive effect or penetrating effect of iRGD peptide when co-administration with iRGD-modified SSL?
Creators: name: Zhang, Wei-Qiang
name: Zhong, Ting
name: Ren, Wei
name: Huang, Dan
name: Song, Ping
name: Li, Dan
name: Zhao, Yang
name: Wang, Chao
name: Zhang, Xuan
name: Yu, Ke-Fu
name: Luo, Li-Min
name: Du, Ruo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Pharmacology
Cell Biology
Biochemistry

description: Ligand-mediated targeting of anticancer therapeutic agents is a useful strategy for improving anti-tumor efficacy. It has been reported that co-administration of a tumor-penetrating peptide iRGD (CRGDK/RGPD/EC) enhances the efficacy of anticancer drugs. Here, we designed an experiment involving co-administration of iRGD-SSL-DOX with free iRGD to B16-F10 tumor bearing mice to examine the action of free iRGD. We also designed an experiment to investigate the location of iRGD-modified SSL when co-administered with free iRGD or free RGD to B16-F10 tumor bearing nude mice. Considering the sequence of iRGD, we selected the GPDC, RGD and CRGDK as targeting ligands to investigate the targeting effect of these peptides compared with iRGD on B16-F10 and MCF-7 cells, with or without enzymatic degradation. Finally, we selected free RGD, free CRGDK and free iRGD as ligand to investigate the inhibitory effect on RGD-, CRGDK- or iRGD-modified SSL on B16-F10 or MCF-7 cells. Our results indicated that iRGD targeting to tumor cells was ligand–receptor mediated involving RGD to αv-integrin receptor and CRGDK to NRP-1 receptor. Being competitive effect, the administration of free iRGD would not be able to further enhance the anti-tumor activity of iRGD-modified SSL. There is no need to co-administrate of free iRGD with the iRGD-modified nanoparticles for further therapeutic benefit.
Efficient Synthesis of Quinolines via a Knoevenagel/Staudinger/aza-Wittig Sequence
Creators: name: Qu, Feng
name: He, Ping
name: Wang, Song
name: Wu, Jing
name: Hu, Ruo-Fei
name: Cheng, Xiao-Hong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Pharmacology
Cell Biology
Biochemistry

description: A simple and efficient method for the construction of quinoline derivatives from 2-azidobenzaldehyde and various carbonyl compounds was developed. The process involves a Knoevenagel condensation of 2-azidobenzaldehyde with carbonyl compound, and subsequently an intramolecular normal Staudinger/aza-Wittig reaction to form the quinolone ring in satisfactory yields.