cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using an artificial neural network to classify multicomponent emission lines with integral field spectroscopy from SAMI and S7
Creators: name: Hampton, E. J.
name: Medling, A. M.
name: Groves, B.
name: Kewley, L.
name: Dopita, M.
name: Davies, Rebecca
name: Ho, I. T.
name: Kaasinen, M.
name: Leslie, S.
name: Sharp, R.
name: Sweet, Sarah
name: Thomas, A. D.
name: Allen, J.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Bryant, J. J.
name: Croom, S.
name: Goodwin, M.
name: Green, A.
name: Konstantantopoulos, I. S.
name: Lawrence, J.
name: Lopez-Sańchez, R.
name: Lorente, N. P.F.
name: McElroy, R.
name: Owers, M. S.
name: Richards, S. N.
name: Shastri, P.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: Integral field spectroscopy (IFS) surveys are changing how we study galaxies and are creating vastly more spectroscopic data available than before. The large number of resulting spectra makes visual inspection of emission line fits an infeasible option. Here, we present a demonstration of an artificial neural network (ANN) that determines the number of Gaussian components needed to describe the complex emission line velocity structures observed in galaxies after being fit with LZIFU. We apply our ANN to IFS data for the S7 survey, conducted using the Wide Field Spectrograph on the ANU 2.3m Telescope, and the SAMI Galaxy Survey, conducted using the SAMI instrument on the 4 m Anglo-Australian Telescope. We use the spectral fitting code LZIFU (Ho et al. 2016a) to fit the emission line spectra of individual spaxels from S7 and SAMI data cubes with 1-, 2- and 3-Gaussian components. We demonstrate that using an ANN is comparable to astronomers performing the same visual inspection task of determining the best number of Gaussian components to describe the physical processes in galaxies. The advantage of our ANN is that it is capable of processing the spectra for thousands of galaxies in minutes, as compared to the years this task would take individual astronomers to complete by visual inspection.
Quadriceps Weakness and the Risk of Knee Cartilage Loss on Magnetic Resonance Imaging in a Population-Based Cohort with Knee Pain
Creators: name: Chin, Carson
name: Sayre, E. C.
name: Guermazi, Ali
name: Nicolaou, Savvas
name: Esdaile, John
name: Kopeć, Jacek A.
name: Thorne, Anona
name: Singer, Joel
name: Wong, Hubert
name: Cibere, Jolanda, 1962-
Publisher: name: The University of British Columbia
Year: 2020

description: Objective. To determine whether baseline quadriceps weakness predicts cartilage loss on magnetic resonance imaging (MRI). Methods. Subjects aged 40-79 with knee pain (n=163) were recruited from a random population sample and examined for quadriceps weakness with manual isometric strength testing, using a 3-point scoring system (0=poor resistance, 1=moderate resistance, 2=full resistance), which was dichotomized as normal (grade 2) vs weak (grade 0/1). MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3-years. Cartilage was graded 0-4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss and, in secondary analyses with compartment specific cartilage loss, adjusted for age, sex, body mass index, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain and baseline MRI cartilage score. Results. Of 163 subjects, 54% were female, mean age 57.7 years. Quadriceps weakness was seen in 11.9% of the subjects. Weakness was a predictor of whole knee cartilage loss (hazard ratio [HR] 3.48, 95% confidence interval [CI] 1.30-9.35). Quadriceps weakness was associated with cartilage loss in the medial tibiofemoral (TF) compartment (HR 4.60, 95% CI 1.25-17.02), while no significant association was found with lateral TF (HR 1.53, 95% CI 0.24-9.78) or patellofemoral compartment (HR 2.76, 95% CI 0.46-16.44). Conclusion. In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. This is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss.
title: Lesiones fibrosas torácicas: correlación radio-patológica
Creators: name: Gomez Barbosa, Carol Fernanda
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar las características radiológicas de las principales lesiones fibrosas en el tórax (pared torácica,
pleura,
mediastino y parénquima pulmonar) Describir su correlación con los hallazgos anatomopatológicos...
Effect of transverse convex surface curvature on fluid flow and heat transfer in the entrance region of concentric annuli.
Creators: name: Suk, Eugene.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Mechanical.

description: The effect of transverse convex surface curvature on turbulent boundary layer flow and heat transfer in the entrance region of concentric annulus is studied analytically. The analytical results are obtained through a turbulent model based on the variable von Karman's constants, $\kappa\sb{\rm i},$ proposed by Kim and Lee in 1995. A computer program is developed for the calculation of the desired hydrodynamic and thermal characteristics. The solutions are found for the case of the heat transfer where the inner core surface is uniformly heated and the outer insulated. It is assumed that the fluid flow is turbulent everywhere and the thermodynamic fluid properties are independent of temperature. It is shown that both the friction factor and Nusselt number increase with the decreasing value of the inner core radius of the concentric annuli, r$\sb{\rm i},$ while the hydrodynamic and thermodynamic entrance lengths decrease with the decreasing value of the inner core radius, r$\sb{\rm i}.$ It is concluded that as in the fully developed turbulent flow, the effect of the transverse convex curvature in the developing region of concentric annuli seems significant.
Daten zur Umwelt 2018: Umwelt und Landwirtschaft
Creators: name: Baumgarten, Corinna
name: Bilharz, Michael
name: Döring, Ulrike
name: Eisold, Andreas
name: Friedrich, Barbara
name: Frische, Tobias
name: Gather, Corinna
name: Große Wichtrup, Walburga
name: Günther, Dirk
name: Hofmeier, Katja
name: Hofmeier, Maximilian
name: Jering, Almut
name: Klatt, Anne
name: Köder, Lea
name: Lamfried, Daniel
name: Langner, Marcel
name: Leujak, Wera
name: Marx, Marc
name: Matthey, Astrid
name: Mohaupt, Volker
name: Osiek, Dirk
name: Penn-Bressel, Gertrude
name: Plambeck, Nils Ole
name: Pohl, Marian
name: Rechenberg, Jörg
name: Scheuschner, Thomas
Publisher: name: My University
Year: 2018
Subjects: subject: Landwirtschaft
subject: Umweltinformation
subject: Ökologischer Landbau
subject: Agrobiodiversität
subject: Düngemittel
subject: Stickstoffüberschuss
subject: Eutrophierung
subject: Nitrat
subject: Daten zur Umwelt
subject: Umweltdaten
subject: Agrarbiodiversität
subject: Pflanzenschutzmittel
subject: Nitrat im Grundwasser
subject: Critical Loads
subject: Nachwachsende Rohstoffe
subject: Bodenerosion
subject: Bodenverdichtung
subject: Gemeinsame Agrarpolitik
subject: Umweltschädliche Subventionen
subject: Biolebensmittel
subject: Lebensmittelverluste
subject: Boden | Fläche
subject: Landwirtschaft

description: Diente die Landwirtschaft früher vor allem dazu, die Menschen im eigenen Land mit Nahrung zu versorgen, ist sie heute Teil weltweiter Handelsströme – vom Import von Futtermitteln bis zum Export von Fleisch in alle Welt. Diese moderne Landwirtschaft produziert große Mengen günstiger Nahrungsmittel, bleibt aber nicht ohne Folgen für die Umwelt. Die vorliegende Broschüre liefert eine Fülle von Zahlen, Daten und Fakten – Grundlage für die Diskussion und um Wege in eine nachhaltigere und umweltschonendere Landwirtschaft zu finden.>> Sollten Sie beim Download der PDF-Datei Probleme haben, versuchen Sie es bitte mit einem anderen Internetbrowser. <<
Transition metal catalyzed oxidative functionalization and preparation of aromatic heterocycles
Creators: name: Stuart, David R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Organic.

description: Aromatic heterocycles, particularly those containing nitrogen, have been identified as important motifs in a wide variety of pharmaceuticals, agrochemicals, fine chemicals, and materials of technological interest. Thus, the development of efficient methods for both the functionalization and preparation of these compounds has received much attention from the synthetic community. Traditional transition metal catalysis has featured prominently in both of these veins; however, there has been a recent surge of interest in the development of catalytic methodologies aimed at the conversion of C-H bonds to more highly oxidized functionality. This body of work describes both the functionalization and preparation of aromatic N-heterocycles in this context. Described in this thesis is the development of methods for both the functionalization and preparation of nitrogen containing aromatic heterocycles from readily available precursors devoid of pre-activation. First, the advancement of palladium(0)-catalyzed direct arylation of quinoline and isoquinoline N-oxides with aryl bromides as a viable solution to the "2-azine organometallic problem" is presented (Chapter 2). This project serves in the formation of the pharmaceutically relevant 2-arylquinolines and 1-arylisoquinolines. These studies also assisted in the identification of a catalyst system (Pd(OAc)2 (5 mol%), PMetBu2·HBF4 (10 mol%)) enabling high regioselectivity in the direct arylation of unsymmetrical azine N-oxides, such as isoquinoline N-oxide and 3-substituted pyridine N-oxides. The experimental observations were validated computationally with a concerted metallation deprotonation transition state model. In a subsequent section, the development and mechanistic investigation of the palladium(I1)-catalyzed oxidative cross-coupling of two unactivated arenes is presented (Chapter 3). The physical parameters of this century-old problem are addressed and observations which may provide solutions to both regio- and chemoselectivity are described for the oxidative arylation of indoles. Protocols for the C2- and C3-oxidative arylation of N-pivaloyl and N-acetylindole, respectively, are offered. Additionally, the mechanism is discussed, including the observation that both the oxidant (AgOAc or Cu(OAc)2) and nitrogen protecting group (pivaloyl or acetyl) appear to have a significant effect on regioselectivity. Finally, the rhodium(III)-catalyzed oxidative coupling of acetanilides or enamides with alkynes to form highly decorated indoles or pyrroles, respectively, is described (Chapter 4). This methodology was applied to the synthesis of Paullone, a pharmaceutical agent. An in-depth mechanistic evaluation of this oxidative indole-forming annulation process based on kinetic studies and free energy correlations is also reported.
title: Características radiológicas en el diagnóstico de hernia interna a través del hiato de Winslow.
Creators: name: Salmerón Ruiz, Ángela
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ischaemia / Infarction
subject: Hernia
subject: Acute
subject: CT-Angiography
subject: CT
subject: Echocardiography
subject: Colon
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Reconocer la anatomía del saco menor. Establecer la semiología en las distintas pruebas de imagen (enema opaco,
ecografía y TC) para el diagnóstico de la hernia a través del hiato de Winslow. Conocer la importancia del diagnóstico precoz para...
title: Complicaciones intraabdominales postquirúrgicas. No todo es absceso.
Creators: name: Romero Cique, Francisco
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
La solicitud de TAC abdominopélvico a pacientes con antecentes de cirugia abdominal y sospecha clínica de complicaciones en su evolución es muy frecuente en nuestro medio. Intentaremos facilitar unas pautas sencillas para poder establecer una...
Examining Patterns of Food Bank Use Over Twenty-Five Years in Vancouver, Canada
Creators: name: Black, Jennifer L.
name: Seto, Darlene
Publisher: name: Springer
Year: 2022

description: Food banks have grown substantially in Canada since the 1980s but little is known about patterns or predictors of engagement including frequency or duration of service use. This study examined food bank program data from a large food bank organization in Vancouver, Canada, finding that between January 1992 and June 2017, at least 116,963 individuals made over 2 million food bank visits. The majority of members were engaged for a short time and came for relatively few visits, but 9% of members engaged in longer-term episodic or ongoing usage over several years, accounting for 65% of all visits. Results from cluster and regression analyses found that documented health and mobility challenges, larger household size, primary income source, and older age were predictors of higher frequency and duration of service usage. Findings add to growing critical examinations of the ‘‘emergency food system’’ highlighting the need for better understanding of the broader social policies influencing food bank use.
Worldwide differences in childhood type 1 diabetes: The SWEET experience
Creators: name: Saiyed, Mahira
name: Hasnani, Dhruvi
name: Alonso, G. Todd
name: Richmond, Erick
name: Besançon, Stéphane
name: Cotterill, Andrew
name: Ngwu, Ursula
name: Mazza, Carmen
name: Rottembourg, Diane
name: Lanzinger, Stefanie
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: children and adolescents
subject: diabetes care
subject: SWEET registry
subject: T1D EXCHANGE
subject: CHILDREN
subject: ADOLESCENTS
subject: OUTCOMES
subject: HBA1C
subject: DDC 610 / Medicine & health
subject: Diabetes mellitus, Type 1
subject: Child
subject: Adolescent
subject: Glycemic control
subject: Glucose
subject: Diabetes mellitus Typ 1
subject: Kind
subject: Jugend

description: Abstract Objective To study worldwide differences in childhood diabetes, comparing relevant indicators among five regions within the SWEET initiative. Subjects We investigated 26 726 individuals with type 1 diabetes (T1D) from 54 centers in the European region; 7768 individuals from 30 centers in the Asia/Middle East/Africa region; 2642 people from five centers in Australia/New Zealand; 10 839 individuals from seven centers in North America, and 1114 patients from five centers in South America. Methods The SWEET database was analyzed based on the following inclusion criteria: T1D, time period 2015‐2019, and age < 21 years, with analysis of the most recent documented year of therapy. For the statistical analysis, we used multivariable linear and logistic regression models to adjust for age (<6 years, 6‐ < 12 years, 12‐ < 18 years, 18‐ < 21 years), gender, and duration of diabetes (<2 years, 2‐ < 5 years, 5‐ < 10 years, ≥10 years). Results Adjusted HbA1c means ranged from 7.8% (95%‐confidence interval: 7.6‐8.1) in Europe to 9.5% (9.2‐9.8) in Asia/Middle East/Africa. Mean daily insulin dose ranged from 0.8 units/kg in Europe (0.7‐0.8) and Australia/New Zealand (0.6‐0.9) to 1.0 unit/kg 0.9‐1.1) in Asia/Middle East/Africa. Percentage of pump use was highest in North America (80.7% [79.8‐81.6]) and lowest in South America (4.2% [3.2‐5.6]). Significant differences between the five regions were also observed with regards to body mass index SD scores, frequency of blood glucose monitoring and presence of severe hypoglycaemia. Conclusions We found significant heterogeneity in diabetes care and outcomes across the five regions. The aim of optimal care for each child remains a challenge.
title: Hg isotopic composition of one-year-old spruce shoots: Application to long-term Hg atmospheric monitoring in Germany
title: Hg isotopic composition of one-year-old spruce shoots: Application to long-term Hg atmospheric monitoring in Germany
titleType: AlternativeTitle
Creators: name: Yamakawa, Akane
name: Fettig, Ina
name: Amouroux, David
name: Koschorreck, Jan
name: Tessier, Emmanuel
Publisher: name: My University
Year: 2021
Subjects: Quecksilber
Biomonitoring
Fichte

description: The Hg isotopic composition of 1-year-old Norway spruce (Picea abies) shoots collected from Saarland cornurbation Warndt, Germany, since 1985 by the German Environmental Specimen Bank, were measured for a better understanding of the temporal trends of Hg sources. The isotopic data showed that Hg was mainly taken up as gaseous element mercury (GEM) and underwent oxidation in the spruce needles; this led to a significant decrease in the Î´202Hg compared with the atmospheric Hg isotopic composition observed for deciduous leaves and epiphytic lichens. Observation of the odd mass-independent isotopic fractionation (MIF) indicated that ÎÌ199Hg and ÎÌ201Hg were close to but slightly lower than the actual values recorded from the atmospheric measurement of the GEM isotopic composition in non-contaminated sites in U.S. and Europe, whereas observation of the even-MIF indicated almost no differences for ÎÌ200Hg. This confirmed that GEM is a major source of Hg accumulation in spruce shoots. Interestingly, the Hg isotopic composition in the spruce shoots did not change very significantly during the study period of >30 years, even as the Hg concentration decreased significantly. Even-MIF (ÎÌ200Hg) and mass-dependent fractionation (MDF) (Î´202Hg) of the Hg isotopes exhibited slight decrease with time, whereas odd-MIF did not show any clear trend. These results suggest a close link between the long-term evolution of GEM isotopic composition in the air and the isotopic composition of bioaccumulated Hg altered by mass-dependent fraction in the spruce shoots. © 2021 The Authors
Supplementary document for Single Molecule Light Field Microscopy - 4736529.pdf
Creators: name: Sims, Ruth
name: Rehman, Sohaib
name: Lenz, Martin
name: Benaissa, Sarah
name: Bruggeman, Ezra
name: Clark, Adam
name: Sanders, Edward
name: Ponjavic, Aleks
name: Muresan, Leila
name: Lee, Steven
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Optical Technology

description: Supplemental document
Angiotensin II modulates glutamate-induced depolarizations and synaptic transmission in rat locus coeruleus neurons in vitro.
Creators: name: Xiong, Huangui.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Biology, Neuroscience.

description: Considerable evidence now supports a neurotransmitter or neuromodulatory role for angiotensin II (AII) in the central nervous system (CNS). The objectives of this research are to study the actions of AII on spontaneous activity and on Glu-induced responses in rat locus coerulus neurons. The action of AII appears to be selective since it had no effect on the depolarizations evoked by acetylcholine (ACh), or by depolarizing current injections. Selectivity is also indicated by the observation that AII had little or no effect on Glu responses in brain stem neurons outside of the LC where AII receptors have not been reported to be present. AII was also found to be subject to rapid peptidase degradation. When AII was applied by bath perfusion, rather than by iontophoretic or pressure application, it had little or no effect on Glu responses. However, when Sar$\sp1$-AII, an analogue which is resistant to aminopeptidase degradation was bath-applied, or when AII was applied together with peptidase inhibitors, the depressant action on Glu responses was observed. Like AII, angiotensin III (AIII) also had depressant actions on Glu responses in LC neurons, but the action of AIII appeared to be less potent than that of AII. In addition to its strong depressant actions on applied Glu-induced responses, AII was also found to depress responses to synaptically released excitatory amino acids (EAAs). In fact we were able to show that excitatory postsynaptic potentials (EPSPs) evoked by electrical stimulation were blocked by Glu receptor antagonists, indicating involvement of EAAs in the mediation of the EPSPs. Sar$\sp1$-AII or AII applied together with peptidase inhibitors depressed the amplitudes of the EPSPs in a concentration dependent manner. The depressant actions of AII on EPSPs were also antagonized by the AT$\sb2$-selective antagonist PD123177, indicating again the involvement of AT$\sb2$ receptors in the mediation of AII action on EAA-induced responses. The functional significance of the depressant action of AII on Glu responses in the LC neurons is at present unclear. It may represent a role for a brain angiotensinergic system in control of cardiovascular functions through modulation of the actions of excitatory amino acid neurotransmitters on LC neuronal activity. (Abstract shortened by UMI.)
"Hustler" et les feministes radicales: Une analyse de la revue à partir de la perspective "pornographie comme violence"
Creators: name: St-George, Joëlle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Women's Studies.
subject: Sociology, Criminology and Penology.

description: Le but de cette étude est d'évaluer l'évolution de la présence des caractéristiques de la pornographie tant revendiqueés par les féministes radicales, caractéristiques fondées sur la prémisse que la pornographie est le moyen fondamental de subordination des femmes. Une analyse quantitative du contenu manifeste nous a permis de constater que Hustler présente une plus grande diversité de photographies au fil des ans. Le nombre de modèles et de scènes présentées augmente de façon significative dans les années '90, offrant ainsi plus de diversité aux lecteurs. Une analyse qualitative du contenu latent nous a aidées à identifier et définir les caractéristiques principales du matériel suite à l'étude de six numéros de la revue. Ces dernières ne sont pas celles qu'avaient dénoncé les féministes concevant la pornographie comme violence. Certains éléments de leur définition de la pornographie s'y retrouvent, mais ont en effet une infime présence dans la revue Hustler, elle qui à l'époque avait tant été critiquée par les féministes. Nous avons développé sur les thèmes suivant: le caractère explicite de Hustler, la réification, la subordination, la violence, les femmes présentées comme des "prostituées", Hustler et les féministes face à face et le lecteur de Hustler. Une étude de quatre numéros supplémentaires nous a permis de confirmer les résultats trouvés dans notre première analyse. Nous avons pu conclure que la dénonciation féministe radicale était peu justifiée en ce qui a trait à la revue Hustler. De plus, nous avons noté que le contenu de ce dernier changeait peu à travers le temps et qu'il ciblait un public spécifique est principalement masculin. D'un autre côte, la revue Hustler ouvre le discours sur la sexualité. (Abstract shortened by UMI.)
Supplementary document for Single Molecule Light Field Microscopy - 4736529.pdf
Creators: name: Sims, Ruth
name: Rehman, Sohaib
name: Lenz, Martin
name: Benaissa, Sarah
name: Bruggeman, Ezra
name: Clark, Adam
name: Sanders, Edward
name: Ponjavic, Aleks
name: Muresan, Leila
name: Lee, Steven
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Optical Technology

description: Supplemental document
A role for the brain sodium, potassium-ATPase alpha2 isoform in salt-sensitive hypertension: Enhanced pressor responses to increased CSF sodium and ouabain concentrations in gene-targeted heterozygous alpha2 sodium, potassium-ATPase knockout mice
Creators: name: Theriault, Steven F
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Neuroscience.
subject: Biology, Animal Physiology.

description: A high-salt diet raises the sodium concentration in the cerebrospinal fluid (CSF [Na+]) in salt-sensitive individuals, an effect that can be mimicked by intracerebroventricular (icv) infusion of NaCl. Increasing CSF [Na+] increases the concentration of an endogenous brain ouabain-like substance(s) (OLS) that inhibits brain Na, K-ATPases, which in turn activates the brain renin-angiotensin system, augmenting sympathetic nervous system activity and blood pressure. It is unknown which of the ouabain-sensitive Na, K-ATPase alpha subunit isoforms (alpha2 or alpha3) in the brain mediates the pressor responses to increased CSF [Na+]. We hypothesize that the alpha2 isoform mediates the pressor responses to elevated CSF [Na +], such that reduced expression of the alpha2 isoform in mice, via heterozygous gene-targeted knockout, should enhance the pressor response to icv infusion of Na+ or ouabain, compared to wildtype litter mates. These studies suggest a critical role for the alpha2 subunit isoform of the Na, K-ATPase in the pressor response to increased CSF [Na+]. (Abstract shortened by UMI.)
'Suppressor of fused' antagonizes hedgehog signaling and is required to maintain retinal progenitor cell identity and multipotency
Creators: name: Cwinn, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.

description: The mature retina consists of six neuronal and one glial cell type that are derived from a pool of mulipotent progenitor cells (RPC). The decision to remain as a multipotent progenitor or to specify a particular retinal cell lineage and differentiate are governed by cell intrinsic and extrinsic factors. Sonic hedgehog (Shh) is a secreted lipoprotein that is motigenic for RPCs and influences cell fate decisions. Suppressor of fused (Sufu) is an intracellular antagonist of the pathway; however, its role in regulating Shh signaling and influencing cell fate decisions in RPCs are unknown. Here, I demonstrate that Sufu antagonizes the Hh pathway in RPCs both in vitro and in vivo. Surprisingly, Sufu was required to maintain early RPC identity and multipotency. Conditional deletion of Sufu in early RPCs resulted in the down-regulation of transcription factors required to maintain RPC identity and multipotency as well as transcription factors required to specify all seven retinal cell types.Sufu-null RPCs were incapable of differentiating into the normal complement of retinal cell types and instead differentiated into restricted subsets of interneurons. These data demonstrate that Sufu antagonizes the Hh pathway in RPCs and provides novel evidence that Sufu is required for proper progenitor cell behavior.
Lesbian coaches: Personal perspectives on being out
Creators: name: Cohen, Elissa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: GLBT Studies.
subject: Health Sciences, Recreation.

description: This research project attempted to identify and describe the essence of the experience of being an out lesbian in elite coaching. Through the use of a feminist epistemology, a phenomenological methodology, and in-depth interviews with eight high performance coaches who identify as lesbian, it was possible to identify and describe the essence of their experiences being out lesbians in elite coaching. The data were analyzed using an inductive phenomenological analysis procedure. The six themes that emerged from the data were: sexism, lesbophobia, the old boys' club, acknowledgement and positive reinforcement, the supportive feminist network, and the nature of the job. Sport was identified as a domain rife with sexism, lesbophobia, and dominated by the old boys' club all of which negatively impacted the lesbian coaches' experiences and career advancement. However, with positive reinforcement of their lesbian identity and the supportive feminist network, the participants nevertheless experienced great personal and professional success.
title: Veröffentlichung des 6. Globalen Umweltberichts (GEO-6) 2019: Analyse der Implikationen für Deutschland
title: Veröffentlichung des 6. Globalen Umweltberichts (GEO-6) 2019: Analyse der Implikationen für Deutschland
titleType: AlternativeTitle
Creators: name: Wolff, Franziska
name: Jacob, Klaus
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Ökologische Situation
subject: GEO-6
subject: Globaler Umweltbericht
subject: Umweltzustand
subject: deutsche Umweltpolitik
subject: Nachhaltigkeitsziele
subject: Nachhaltigkeit | Strategien | Internationales

description: Mit dem Vorhaben „Veröffentlichung des 6. Umweltberichts der ⁠UNEP⁠ (GEO-6) 2019: Analyse der Implikationen für Deutschland“ sollte eine Brücke zwischen der Veröffentlichung GEO-6 auf ⁠UN⁠-Ebene und der nationalen Debatte geschlagen werden. In einem Hintergrundpapier wurden zentrale Befunde des GEO-6 ausgewertet und aktuellen Daten für Deutschland gegenübergestellt. In einem Shortpaper wurden die zentralen Befunde des GEO-6 und die Schlussfolgerungen für die Weiterentwicklung der deutschen Umwelt- und Nachhaltigkeitspolitik weiter aufbereitet. Adressaten waren Akteure aus Wissenschaft und Zivilgesellschaft sowie Vertreterinnen und Vertreter der Politik (u. a. Bundestag, Ministerien). Das Shortpaper wurde auch gegenüber der Presse kommuniziert und bei der Vorstellung des GEO-6 in Berlin präsentiert.
Antimicrobial activity of cyclic-monomeric and dimeric derivatives of the snail-derived peptide Cm-p5 against viral and multidrug-resistant bacterial strains
Creators: name: González-García, Melaine
name: Morales-Vicente, Fidel
name: Pico, Erbio Díaz
name: Garay, Hilda
name: Rivera, Daniel G.
name: Grieshober, Mark
name: Raluca Olari, Lia
name: Groß, Rüdiger
name: Conzelmann, Carina
name: Krüger, Franziska
name: Zech, Fabian
name: Prelli Bozzo, Caterina
name: Müller, Janis A.
name: Zelikin, Alexander
name: Raber, Heinz
name: Kubiczek, Dennis
name: Rosenau, Frank
name: Münch, Jan
name: Stenger, Steffen
name: Spellerberg, Barbara
name: Franco, Octavio L.
name: Rodriguez Alfonso, Armando A.
name: Ständker, Ludger
name: Otero-Gonzalez, Anselmo J.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: antimicrobial peptides
subject: Cm-p5
subject: antibacterial activity
subject: multiresistant microorganisms
subject: chemical derivatives
subject: STRATEGIES
subject: MECHANISM
subject: ROLES
subject: DDC 570 / Life sciences
subject: Peptide antibiotics
subject: Antibacterial agents
subject: Zika virus
subject: Infection
subject: Mechanism of action (Biochemistry)
subject: Infektion
subject: Schutzanpassung
subject: Abwehrmechanismus

description: Cm-p5 is a snail-derived antimicrobial peptide, which demonstrated antifungal activity against the pathogenic strains of Candida albicans. Previously we synthetized a cyclic monomer as well as a parallel and an antiparallel dimer of Cm-p5 with improved antifungal activity. Considering the alarming increase of microbial resistance to conventional antibiotics, here we evaluated the antimicrobial activity of these derivatives against multiresistant and problematic bacteria and against important viral agents. The three peptides showed a moderate activity against Pseudomonas aeruginosa, Klebsiella pneumoniae Extended Spectrum β-Lactamase (ESBL), and Streptococcus agalactiae, with MIC values > 100 µg/mL. They exerted a considerable activity with MIC values between 25–50 µg/mL against Acinetobacter baumanii and Enterococcus faecium. In addition, the two dimers showed a moderate activity against Pseudomonas aeruginosa PA14. The three Cm-p5 derivatives inhibited a virulent extracellular strain of Mycobacterium tuberculosis, in a dose-dependent manner. Moreover, they inhibited Herpes Simplex Virus 2 (HSV-2) infection in a concentration-dependent manner, but had no effect on infection by the Zika Virus (ZIKV) or pseudoparticles of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). At concentrations of >100 µg/mL, the three new Cm-p5 derivatives showed toxicity on different eukaryotic cells tested. Considering a certain cell toxicity but a potential interesting activity against the multiresistant strains of bacteria and HSV-2, our compounds require future structural optimization.
A distributed location-aware routing architecture for P2P massively multiplayer online games
Creators: name: Ratti, Saurabh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Engineering, Electronics and Electrical.

description: Populations in contemporary Massively Multiplayer Online Games (MMOG) continue to grow, a trend that current client-server architectures are hard pressed to sustain. Application of peer-to-peer concepts and technologies to the domain of MMOG communications can address the issues of scalability and single points of failure associated with the client-server model. A proposed system takes an existing peer-to-peer network overlay as a foundation for peer connection management, and adapts it to have location-awareness by applying the Hilbert Space-Filling Curve. The new routing architecture's location awareness is done with respect to the virtual environment, in order to achieve area-of-interest updates to interested peers with the latency of a single hop. This is done in manner that is fully distributed, thus sharing the work load as evenly as possible across peers without requiring centralized servers. This thesis reviews existing approaches, details the proposed system, and finally presents a proof-of-concept and associated evaluations.
The heterotrophic culture of Chlorella protothecoides for the production of lipids
Creators: name: Ho, Jennifer Chin Chin
Publisher: name: Swinburne
Year: 2024

description: In this age of concern about dwindling supplies of fossil fuels, research into alternative and especially renewable fuels is growing. Microalgae are seen to have potential as a source of biodiesel fuels via the lipids that they can produce. In this project, Chlorella protothecoides, a microalga which is claimed able to accumulate lipids to between 60 and 75%, was chosen for study of the heterotrophic production of lipids. The objectives of the project were to discover via examination of a sequence of fermentation variables, a set of conditions for good lipid yield, to elucidate the relationship between cell growth and lipid production, and to obtain quantitative data to characterize lipid production by Chlorella protothecoides UTEX250. Specific Growth Rate and Specific Rate of Lipid Production data indicate that lipid production by Chlorella protothecoides has the pattern of a primary metabolite when cultured at 25 degrees C. However, when incubated at 35 degrees C, the data suggests that lipids are a secondary metabolite. In shake flask culture, when an inoculum size of 20%, incubation temperature of 35 degreesC, shaking speed of 200 r.p.m., initial glucose concentration of 1.5%, a C:N ratio of 150 in the medium, and the culture pH is uncontrolled, a lipid yield of 44.8% of dry cell weight can be obtained. The lipids were produced with Yx/s at 3.23 and Yp/s at 0.066. When translated to a 4 L bioreactor culture, the lipid yield was similar at 46.1%. These results are at the lower end of a range of yields obtained in other heterotrophic studies with Chlorella protothecoides (46 -58%).
Seeding long-term, sustainable change in teacher preparation programs: the case of PhysTEC
Creators: name: Foote, Kathleen T
name: Knaub, Alexis V
Publisher: name: Springer International Publishing
Year: 2018

description: Background: The continuation of teacher preparation activities after a 3-year Physics Teacher Education Coalition (PhysTEC) grant is used as a case study to examine multi-faceted aspects of sustainable change in higher education. Since teacher preparation is outside typical physics departmental activities, success is highly dependent on finding a department and institution who values this cause. Throughout the history of providing grants, PhysTEC has identified ten components of successful sites that they consider during the selection process. In this paper, we retrospectively analyze characteristics of six comprehensive PhysTEC sites, to see how department histories, values, and activities affect long-term sustainability as sites moved from grant funding to matched institutional funding and beyond. Results: The most important components required to sustain these programs were (1) institutional commitment—both financial support as well as intellectual and cultural support for potential teachers—(2) champion, a respected change agent at the university who ensures program success through advocacy and support, and (3) activities that enhance not only the production of teachers but also the undergraduate education activities of the department. Of the six PhysTEC sites, three sites were able to institutionalize the majority of PhysTEC activities into departmental routine. These three sites have departmental leadership and administrators who valued and invested in physics teacher preparation. At these sites, PhysTEC symbiotically supported typical departmental activities including increasing majors, improving courses, and involving undergraduates to support teaching. Two sites were sustaining activities at the time of study but attitudes toward teaching as a profession were mixed so continued sustainability is precarious and reliant on external funding. One site discontinued the majority of PhysTEC activities because of a lack of alignment with a different physics teacher initiative on campus. Conclusions: Because physics teacher preparation is not often prioritized as a part of undergraduate departmental activities, success emerges when departmental and institutional value systems align with this goal. PhysTEC funding is not enough to create this culture; it must exist prior to funding. Sustaining PhysTEC activities is easier when they are seen as enhancing the undergraduate experience as a whole. The PhysTEC grant helped bring physics teacher preparation to the forefront, and a well-respected champion in a leadership position can help set this tone and advance departmental activities accordingly. This study has implications for sustaining reforms of typically undervalued activities in higher education or secondary teacher preparation programs in any discipline.
Socioeconomic status, well-being and mortality: a comprehensive life course analysis of panel data, Germany, 1984-2016
Creators: name: Montano, Diego
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Socioeconomic determinants of health
subject: Life satisfaction
subject: Satisfaction with health
subject: DDC 570 / Life sciences
subject: Longevity
subject: Social Determinants of Health
subject: Longitudinal Studies
subject: Langlebigkeit
subject: Längsschnittuntersuchung

description: Background: This study seeks to explore potential causal mechanisms involved in the observed associations between several socioeconomic status (SES) indicators, well-being and mortality, by taking a life course perspective focusing on (i) the trajectory of income and domain-specific well-being indicators, (ii) the influence of different SES indicators on well-being and mortality, (iii) the interactions between those trajectories, and (iv) the associations of the income and domain-specific well-being trajectories with all-cause mortality. Methods: Socioeconomic status is operationalised by net household income, education, employment and marital status. Well-being is measured with two indicators: life satisfaction and satisfaction with health. Data from the German Socio-Economic Panel, collected between 1984 and 2016 and comprising more than 55,000 individuals, are analysed by means of longitudinal k-means cluster analysis, simultaneous equation systems and parametric time-to-death regressions. Results: The analyses indicate the presence of large reciprocal effects of the trajectories of income and well-being on each other. However, the results suggest that well-being has a larger influence on income than the opposite, namely, income on well-being. The mortality analysis, on the other hand, revealed that the history of satisfaction with health is a much stronger predictor of longevity than the individual’s income history. Mortality risk was found lower among married individuals and those with tertiary education. In contrast, unemployment was associated with lower income and well-being levels. The findings provide support to the notion that education is a superior SES indicator than income in the investigation of the social determinants of well-being and mortality. Conclusion: The present study provides evidence of large reciprocal effects of income and well-being and emphasises the importance of taking a life course approach in the investigation of the social determinants of health. Several SES indicators and both well-being indicators were found to be highly predictive of all-cause mortality and indicate the presence of cumulative effects related to one’s income and well-being trajectories.
JNK inhibitor IX restrains pancreatic cancer through p53 and p21
Creators: name: Shi, Jingwei
name: Yang, Xing
name: Kang, Qi
name: Lu, Jian
name: Denzinger, Maximilian
name: Kornmann, Marko
name: Traub, Benno
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Pancreatic cancer
subject: c-Jun N-terminal kinase
subject: JNK inhibitor IX
subject: Cell cycle arrest
subject: G2 arrest
subject: DDC 610 / Medicine & health
subject: Pancreatic neoplasms
subject: Cell cycle
subject: Bauchspeicheldrüsenkrebs
subject: Zellzyklus

description: Novel treatment options for pancreatic cancer are desperately needed. De-regulated kinases can be regularly detected in pancreatic cancer. Multiple pathway inhibitors were developed to exploit these features, among them selective inhibitors of the c-Jun N-terminal kinase isoforms 1 and 2 (JNK1 and 2). We evaluated the effectiveness of four different JNK inhibitors on pancreatic cancer cell lines. Cell mobility and migration were evaluated in scratch assay and Boyden chamber assay. Mechanism of cell death was analyzed via apoptosis assays in FACS and immunoblotting as well as cell cycle analysis via FACS, and qPCR. JNK2 knockout cells were generated using siRNA transfection. Among the inhibitors, JNK inhibitor IX (JNK-in-IX), designed as specific inhibitor against JNK2 was proven highly effective in inhibiting cell growth, mobility and migration. We were able to show that JNK-in-IX caused DNA damage resulting in G2 arrest mediated through p53 and p21. Interestingly, JNK-in-IX acted independently of its primary target JNK2. In summary, JNK-in-IX was shown highly effective in pancreatic cancer. This study underlines the need for modeling systems in testing therapeutic options as JNK2 was previously not indicated as a potential target.
Supplementary document for Boosting optical nonreciprocity: Surface reconstruction in iron garnets - 4736682.pdf
Creators: name: Levy, Miguel
name: Dash, Sushree
name: Mukherjee, Pinaki
name: Haskel, Daniel
name: Rosenberg, Richard
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Material
Circular Dichroism in Multiphoton Ionization of Resonantly Excited He+ Ions
Creators: name: Ilchen, M.
name: Douguet, N.
name: Mazza, T.
name: Rafipoor, A. J.
name: Callegari, C.
name: Finetti, P.
name: Plekan, O.
name: Prince, Kevin
name: Demidovich, A.
name: Grazioli, C.
name: Avaldi, L.
name: Bolognesi, P.
name: Coreno, M.
name: Di Fraia, M.
name: Devetta, M.
name: Ovcharenko, Y.
name: Düsterer, S.
name: Ueda, K.
name: Bartschat, K.
name: Grum-Grzhimailo, A. N.
name: Bozhevolnov, A. V.
name: Kazansky, A. K.
name: Kabachnik, N. M.
name: Meyer, M.
Publisher: name: Swinburne
Year: 2024

description: Intense, circularly polarized extreme-ultraviolet and near-infrared (NIR) laser pulses are combined to double ionize atomic helium via the oriented intermediate He+(3p) resonance state. Applying angle-resolved electron spectroscopy, we find a large photon helicity dependence of the spectrum and the angular distribution of the electrons ejected from the resonance by NIR multiphoton absorption. The measured circular dichroism is unexpectedly found to vary strongly as a function of the NIR intensity. The experimental data are well described by theoretical modeling and possible mechanisms are discussed.
Association of Television Viewing Time with Body Composition and Calcified Subclinical Atherosclerosis in Singapore Chinese
Creators: name: Nang, Ei Ei Khaing
name: Dam, Rob M. Van
name: Tan, Chuen Seng
name: Mueller- Riemenschneider, Falk
name: Lim, Yi Ting
name: Ong, Kai Zhi
name: Ee, Siqing
name: Lee, Jeannette
name: Tai, E. Shyong
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective Sedentary behavior such as television viewing may be an independent risk factor for coronary heart disease. However, few studies have assessed the impact of television viewing time on coronary artery calcification and it remains unclear how body fat contributes to this relationship. The aim of this study is to evaluate the association between television viewing time and subclinical atherosclerosis and whether effects on visceral or subcutaneous fat may mediate any associations observed. Methods This was a cross-sectional study of 398 Chinese participants (192 men and 206 women) from Singapore prospective study. Participants were free from known cardiovascular diseases and underwent interview, health screening, computed tomography scans of coronary arteries and abdomen. Spearman’s correlation was used to test the correlation between television viewing time, physical activity, body composition and abdominal fat distribution. The association between television viewing time and subclinical atherosclerosis was assessed by multiple logistic regression analysis. Results In men, television viewing time was significantly correlated with higher body fat mass index, percent body fat, subcutaneous and visceral fat. These associations were in the same direction, but weaker and not statistically significant in women. Television viewing time (hours/day) was associated with subclinical atherosclerosis in men (odds ratio: 1.41, 95% CI: 1.03-1.93) but no significant association was observed in women (odds ratio: 0.88, 95% CI: 0.59-1.31) after adjusting for potential socio- demographic and lifestyle confounders. Further adjustments for biological factors did not affect these associations. Conclusions Television viewing time was associated with greater adiposity and higher subcutaneous and visceral fat in men. TV viewing time was also associated with subclinical atherosclerosis in men and the potential mechanisms underlying this association require further investigation.
Supplementary document for Boosting optical nonreciprocity: Surface reconstruction in iron garnets - 4736682.pdf
Creators: name: Levy, Miguel
name: Dash, Sushree
name: Mukherjee, Pinaki
name: Haskel, Daniel
name: Rosenberg, Richard
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary Material
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 347 (49. Jg), Februar/März 2019
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Energie für die Mobilität der Zukunft
subject: Mission Statement
subject: Trauma SFB verlängert
subject: Lehre im Fokus: Vom Tutorium bis zum digitalen Coach
subject: DDC 050 / General serial publications
subject: Universities; Germany; Ulm
subject: Universities and colleges; Germany
subject: Universität Ulm

description: uni ulm intern - das Ulmer Universitätsmagazin mit Themen aus Forschung, Lehre und vom Campus
description: uni ulm intern, Das Ulmer Universitätsmagazin mit Themen aus Forschung, Lehre und vom Campus, Heft Nr. 347 (49. Jahrgang), Februar/März 2019