cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Personae - Manuscripts, typescripts, of Gallup A3
Creators: name: Pound, Ezra, 1885-1972
Publisher: name: University of Victoria Libraries
Year: 2024
Subjects: subject: Creation (Literary, artistic, etc.)
valueUri: http://id.worldcat.org/fast/882393
subject: Literary collections
valueUri: http://id.worldcat.org/fast/1423811
subject: Literature
valueUri: http://id.worldcat.org/fast/999953
subject: Authors, American
valueUri: http://id.worldcat.org/fast/821764
subject: Poets, American
valueUri: http://id.worldcat.org/fast/1067794
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Authorship
valueUri: http://id.worldcat.org/fast/822442
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778

description: The archive consists of virtually all the manuscripts used for printing Personae: the first fifteen poems were probably printed from a marked copy of A Lume Spento. There are ninety-eight pages of holograph manuscripts, some being notes on the versos, and eleven pages of corrected typescripts. Of the thirty-three poems in the 1909 edition of Personae, there are eighteen present: five exist in one draft, eleven in two drafts, and two in three drafts. Pencil markings denote the printer's copy-text drafts of all eighteen poems. The worksheets are sometimes initial drafts and sometimes obvious redraftings transcribed from earlier compositions. The manuscripts begin with "Praise of Ysolt" (p. 28 of the published book) and of the poems which follow, only "Comraderie [Camaraderie]", "Masks", "Ballad for Gloom" and "For E. McC." are lacking (all these latter had already been published in A Lume Spento). The versos of the manuscripts contain an interesting variety of notes, a draft of "Roundel" (not published in Pound's lifetime) and what appears to be an early plan for the book (E.P. Po. 76). Of the variants present in the manuscripts, the most interesting are the notes that Pound cut from the text and particularly from the appendix "Notes on New Poems". For variants see "Personae: From Manuscript to Print", [Studies in Bibliography, Dec. 1981].
Self-Disclosure by Adolescents in therapy for Eating Difficulties: A Q-Methodological Study
Creators: name: DUNLOP, RHIANNON
Publisher: name: University of Surrey
Year: 2021

description: Background: Eating disorders are highly prevalent within the adolescent population with poor recovery rates if treatment is not accessed soon after onset. Self-disclosure is an important issue for clinicians and researchers given the impact it has on the effectiveness of treatment. The aim of the present study was to investigate factors that were considered likely to impact adolescent’s decision to self-disclose during psychological therapy for eating difficulties. Method: Participants were recruited through a CAMHS eating disorder service. Twenty-Eight participants took part in the study and completed the Q-sort task, which asked them to rank 47 statements relative to one another onto a grid with what was more likely influence their decision to disclose at one end and what was less likely influence their decision to disclose at the other end. Ken-Q Analysis was used to analyse the data. Findings: Three factors were extracted from the data. Factor 1 was a bipolar factor with seven significant positively loading, and five significant negatively loading Q-sorts. Those who negatively loaded onto the factor held an inverted view. Elements connected with therapist self-disclosure were important in this factor. The second factor considered elements of the eating disorder identity and readiness to change as influencing the decision to disclose. And the last factor suggested that the quality of the therapeutic relationship and readiness to change were the most influential elements influencing the decision to disclose. Conclusions: The findings of the study suggest that no united viewpoint is held on what influences the decision to disclose by those experiencing eating difficulties. Clinicians should therefore ensure they explore with clients what might influence their decision to disclose as knowing this would enhance the effectiveness of treatment.
Kindersoldaten im Krieg
Creators: name: Estremera, Stella A.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Wenn vom Krieg die Rede ist, stellen wir uns vor, wie unsere Soldaten — kräftige junge Männer und hochrangige Funktionäre mit düsterem, entschlossenem Ausdruck — zu Hunderten ins ferne Basilan geschifft werden, um den Feind in Stücke zu schlagen. Ansonsten denken wir an Kräfte der Vereinten Nationen in Wüstentarnung, die mit Panzern umherfahren oder starke Bomber mit mächtigen Wurfgeschossen beladen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
title: Organisational learning from patient complaints
title: A case study exploring professional hierarchies and customary practices
titleType: Subtitle
Creators: name: BOLGER, SARAH BETH
Publisher: name: University of Surrey
Year: 2020

description: Patient complaints are vital indicators of learning opportunities to improve care. Complaints are considered, within current research, as valid as the learning opportunities reported by staff through patient safety systems (Christiaans-Dingelhoff et al., 2011, Clwyd and Hart, 2013). However, there is little research exploring the barriers to why complaints are not used to their full potential. Therefore, this thesis presents an in-depth case study of a large teaching hospital in the South of England.
description: The aim of this study was to explore how the beliefs and customary practices of clinical leaders are influential in organisational learning from patient complaints in the clinical environment within a large acute care hospital in the south of England. This study focused on the customary practices within the professional hierarchy and how they impacted on organisational learning from patient complaints.
description: Data was collected between January and June 2017, comprising n=25 one-to-one interviews of clinical leaders (staff grade ST3 and band 6 or above), n=9 observations of meetings where complaints were discussed, and documentary analysis of the minutes of those meetings. Thematic analysis was applied to the data coded through Nvivo v11, from which three novel findings emerged. 1. Blame cultures were present in the clinical environment which created intimidating and pressurised opportunities to learn within the context of patient complaints. 2. Clinical leaders used the professional hierarchy to maintain power and to continue unsupportive customary practices towards complaints. 3. Clinical leaders often did not consider patient complaints to highlight any significant learning opportunities.
description: This thesis highlights a stark contrast between expectations towards learning from patient complaints by government reports, professional governing bodies, and the reality of the clinical environment. The concepts highlighted within this study enable a novel in-depth understanding of the barriers, and present solutions for further development. This study presents new ways of conceptualising organisational learning from patient complaints and has the potential to influence future studies and strategies to improve patient experience, reduce mortality and morbidity, reduce repetitive litigation costs and ultimately improve care.
On answering why and why-not questions in databases
Creators: name: Islam, Md.Saiful
Publisher: name: Swinburne
Year: 2024

description: When we speak of database usability, we mean much more than just the user interface, the user interface is only a part of the usability equation. These days, users expect the systems to be more interactive and cooperative. In particular, users may want to know why an unexpected object appears in the result set and similarly, why an expected object does not appear in the result set. This thesis provides effective and efficient techniques to answer such questions on received results. We believe that the research undertaken in this thesis can contribute towards improving the usability of traditional database systems.
Wahrheit, die keiner hören möchte: Eine Studie über Kindesmissbrauch in den Philippinen
Creators: name: Go, Miriam Grace A.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Die NGO Community and Family Services International (CFSI) hat im Jahre 1999 eine Studie zum Thema sexueller Missbrauch von Kindern in den Philippinen erstellt. Landesweit wurden 708 Fälle untersucht. Die Informationen basieren auf den Angaben verschiedener staatlicher Einrichtungen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Lumads an die Uni: Unterstützungsprogramme für junge Indigene auf Mindanao
Creators: name: Tan, Tiffany
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Bananen haben dem zehnjährigen Ettok Umpan den Schulbesuch ermöglicht Als achtes von elf Kindern reichte das Geld in der Familie oft nicht für drei Mahlzeiten am Tag. Doch der Junge von der Gruppe der Obo Manobo pflückte ein paar reife Bananen vom Hinterhof und tauschte sie bei seinen Klassenkameraden gegen Bleistifte und Papier ein.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
2849530.pdf
Creators: name: Morrison, Blair
name: Casas-Bedoya, Alvaro
name: Ren, Guanghui
name: Vu, Khu
name: Liu, Yang
name: Zarifi, Atiyeh
name: Nguyen, Thach
name: Choi, Duk-Yong
name: Marpaung, David
name: Madden, Steve
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
Reconceptualisation of Digital Cultures of DMOs through an Enhanced Digital Platform
Creators: name: ZAINAL ABIDIN, HUSNA BINTI
Publisher: name: University of Surrey
Year: 2021

description: The advancement of technology has revolutionised the tourism industry. However, Destination Management Organisations (DMOs), in general, have yet to undertake holistic technological solutions in addressing their expected roles and responsibilities, particularly with regards to its role in supporting online collaborations. Greater understanding is required on the functional capabilities needed by both business stakeholders and visitors to provide holistically integrated applications for digital collaborations. Therefore, this research aims to critically discuss the roles and mechanisms in which DMOs become points of consolidation and collaboration for tourism businesses through digital platforms and the functionalities for end-user experience creation. Hence, identifying the characteristics and operational capabilities that enhanced digital platforms of DMOs need to have as part of their functions.
description: A design-based research approach with three phases was used for the research. Phase 1 explored the understanding and usage of current digital offerings as well as existing collaboration practices. Findings from Phase 1 were used to guide the development of a digital trial platform in Phase 2. The subsequent platform testing in Phase 3 was conducted to further strengthen the understanding of digital collaborations and to establish the needed functionalities for enhanced digital platforms. Data were collected primarily through qualitative methods (interviews and focus groups) with the support of quantitative and visual methods using an eye-tracker device. Findings demonstrate the need for DMOs to provide distinct value propositions of experience creation on their digital platform for business stakeholders and visitors. Therefore, an enhanced digital platform must be equipped with the functionalities for knowledge exchange, networking and marketing for business stakeholders, and personalisation of itineraries and travel information for visitors. The functional capabilities of digital collaboration are underpinned by the concepts of trust, control, leadership, and the willingness to collaborate. As such, the research contributes to the existing knowledge on technology influenced DMO management.
On doing being normal: An ethnomethodological analysis of dream telling in two interactional contexts
Creators: name: LOCKE, LORRAINE CHARLOTTE
Publisher: name: University of Surrey
Year: 2021

description: Despite their ubiquity as shared social phenomena, limited sociological attention has been given to dreams. Moreover, where dreams have been considered, there is a tendency to treat the talk that is generated in dream telling settings as a resource from which analytical and theoretical claims are made, rather than perceiving it as a topic in its own right. Furthermore, the sociological literature tends to treat culture as being reflected in dreams. The thesis remedies these problems by treating talk about dreams, collected in interviews about dreams, and interviews about sleep and recovery, as its central phenomenon. It combines conversation analysis (CA) and membership categorisation analysis (MCA) to examine the sequential and categorial practices members of these settings use to produce, negotiate, and manage representations of self. The thesis aims to further develop the trajectory of work that brings CA and MCA together. It shows how participants ‘police’ the boundaries between the dreaming and waking world by using newly identified contrast structures that are produced to describe the facticity of dreamt events and to display normative identities when dreamt and waking selves have been breached. By showing how identity is worked up both sequentially and categorially, it illustrates an overriding concern with morality and culture. Furthermore, it shows that culture is not reflected in dreams, rather, it is displayed in and through talk about them. The thesis makes important contributions to the sociology of sleep and dreams; it makes links between addiction, recovery, and identity, which opens potential new lines of enquiry. It also contributes to CA/MCA research on qualitative research interviews by showing how interviewer (IR) and interviewee (IE) identities are negotiated on a moment-by-moment, occasion-by-occasion basis. Overall, it shows being normal is accomplished in these situated contexts.
Investigation of novel methods for detecting poxvirus infection and innate immune activation
Creators: name: Lant, Sian Frances
Publisher: name: University of Surrey
Year: 2024
Subjects: Poxvirus
cGAS

description: Poxviruses are large dsDNA viruses that replicate in the cytosol. Upon entry, the virus core expands allowing early gene expression, followed by core disassembly, then genome release and replication within viral factories. Some poxviruses fail to grow in mammalian cell culture; however receptor specificity does not determine this. All poxviruses should enter cells and generate early mRNA. Besides mediating core disassembly and genome release, early gene expression is also crucial to subvert host defences. In this thesis the hypothesis that the early events in poxvirus infection are a method of preventing innate immune sensing were investigated alongside whether these events could be exploited to generate novel detection methods.No quantitative reporter cell line exists for poxviruses. Here, a fluorescent reporter cell line is presented for poxvirus detection based on the use of reverse transcriptase (RT) to create cDNA from an mRNA reporter cassette. Stable cell lines expressing the reporter cassette and RT showed detectable fluorescence upon infection with several poxvirus species. The dynamics of activation correlated with virus multiplicity and replicative cycle. This cell line offers distinct advantages over alternative detection methods, such as detecting infectious virus, offering the possibility of propagating the virus and being a rapid pan-poxvirus detection method.Viruses lacking the cGAMP nuclease (Poxin/vSlfn) activate an antiviral response that depends on the cellular DNA sensor cGAS. Here, these viruses are used to show poxvirus sensing occurs prior to virus genome replication, but this is prevented by Poxin/vSlfn expression during uncoating. Unexpectedly, despite sensing replicated genomes, cGAS is excluded from viral factories and accumulates in the nucleus. These data indicate that despite replication in the hostile cytosolic environment, poxviruses have evolved complex processes preventing immune recognition and activation. Whether these functions are conserved in all poxviruses or how they co-operate with Poxin/vSlfn remains unknown.
2849530.pdf
Creators: name: Morrison, Blair
name: Casas-Bedoya, Alvaro
name: Ren, Guanghui
name: Vu, Khu
name: Liu, Yang
name: Zarifi, Atiyeh
name: Nguyen, Thach
name: Choi, Duk-Yong
name: Marpaung, David
name: Madden, Steve
Publisher: name: Optica Publishing Group
Year: 2017
Subjects: Uncategorized

description: Supplemental document
Experimental studies of nuclear structure and shape phenomena around the N=Z line
Creators: name: BELVEDERE, CARMINE KEVIN
Publisher: name: University of Surrey
Year: 2022

description: The low-energy Coulomb excitation of 72Se experiment was conducted using the Miniball/CD detector setup to detect prompt gamma rays in coincidence with scattered particles at the HIE-ISOLDE facility at CERN. The quadrupole moment (QM), hereafter always recorded in units of eb, was deduced to be $Q_s({2_1^+}) = -0.24^{+0.13}_{-0.22}$, implying a prolate configuration; this first independent measure is in agreement with the only other experimentally reported value, which was published during this thesis project. The prolate shape of this state confirms that shape inversion to oblate configurations near the ground state does not occur until at least 70Se. The QM for the ${2_1^+}$ state in the beam contaminant 68Ge is found to be $Q_s({2_1^+}) = -0.39^{+0.33}_{-0.17}$, implying prolate configuration; this is the first experimentally deduced value of this QM and represents the first post-acceleration of a radioactive neutron-deficient Ge isotope at an ISOL facility. Gamma-ray spectroscopy of 60Zn was conducted at Argonne National Laboratory (ANL) using the ATLAS accelerator for the production of a 3He beam directed onto an enriched 58Ni target. This induced the 58Ni(3He,n) light-ion fusion-evaporation reaction and the Gammasphere detector array was used for detection of prompt gamma-rays following the reaction. A firm assignment for the $2_2^+$ state is made, as well as previously unknown structures built above the $2_2^+$ state and $3_1^+$ state being discovered. Several new states with transitions decaying to the $4_1^+$ state are also observed. Some states potentially corresponding to resonances in the astrophysical 59Cu(p,gamma) reaction are identified. First observation of these states provides critical information for follow-up work to obtain the reaction rate. The level density deduced is in agreement with the recent work of Soltesz et al. using no gamma-decay information.
Investigating stress granule properties and translation in cell-based models of neurodegenerative disease
Creators: name: Relton, Emily Louise
Publisher: name: University of Surrey
Year: 2024
Subjects: Neurodegeneration
Stress granules
Batten Disease
Translation

description: Neurodegenerative diseases (NDs) encompass a heterogeneous group of disorders that result in neuronal degeneration, leading to physical and cognitive decline and ultimately death. Although NDs have been the focus of intense research efforts, they are poorly understood, largely untreatable and represent a huge global health and economic challenge within an aging population. Stress granules (SGs) are membrane-less organelles comprised of mRNA and protein that modulate signalling pathways in response to stress, promoting cell survival. Links between SG dysfunction and human disease including NDs are well established. This thesis aimed to characterise SG properties and dynamics in iPSC-derived models of Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and a HeLa model of CLN3 Batten disease (BD), a cause of juvenile neurodegeneration. By investigating the properties and dynamics of SGs we hoped to understand commonly deregulated pathways which would advance shared understanding of how SGs drive pathogenesis in NDs. In chapters 3 and 4, we show the characterisation of neuronal precursor cell (NPC) models, techniques for SG visualisation and assessment of their clearance dynamics, as well as quantification of translation efficiency. We show aberrant SG properties and alter removal dynamics, as well as translational defects are associated with mutations causative of ALS/FTD and AD. Chapter 5 shows the optimisation of assays used in preceding chapters in terminally differentiated neurons. Section 6 is adapted from a recent publication (Relton et al, 2023). In this study we show SG dysfunction is also associated with loss of BD related gene CLN3. As interest grows into the use of SG modulating drugs to alleviate NDs pathology, this work uncovers dysregulated SG biology across a range of novel ND models. These findings will aid further knowledge in the field of SGs and disease, with the ultimate goal of discovering new targets for therapeutic development.
Development of Direct Analyte-Probed Nanoextraction Liquid Chromatography Mass Spectrometry (DAPNe-LC-MS) as a novel approach for the analysis of biological samples
Creators: name: LEWIS, HOLLY-MAY
Publisher: name: University of Surrey
Year: 2021

description: "This thesis explores further development of a liquid sampling technique called direct analyte probed-nanoextraction (DAPNe) to analyse animal tissues and cells. DAPNe uses a nanocapillary to sample analytes from a surface at micron dimensions, and has been previously used for the analysis of forensic traces and single cells.
description: DAPNe sampling is typically followed by mass spectrometry analysis. Sample introduction is conventionally via nanospray ionisation (NSI). This thesis describes research exploring the possibility of introducing liquid chromatography as an additional step into the workflow to improve precision and selectivity.
description: A comparison of the baseline sensitivity of DAPNe-NSI and DAPNe-LC-MS for drugs in homogenised tissue showed that the addition of LC-MS into the workflow can be used to improve precision compared with NSI, particularly if an internal standard is not available, or an untargeted analysis is to be carried out.
description: The DAPNe-LC-MS method was optimised for the detection of anti-tuberculosis drugs in tissues, by making improvements to the repeatability of the sampling area and transfer efficiency. The developed method was sufficient to probe the anti-TB drug bedaquiline in different compartments of a TB granuloma. Elemental imaging using particle induced X-ray Emission (PIXE) was used to validate the DAPNe measurements.
description: The DAPNe-LC-MS approach was further adapted and tested for the feasibility for providing spatially resolved lipidomics analysis. The technique was compared to laser capture microdissection (LCM), followed by LC-MS for providing spatially resolved lipid profiles. Whilst the LCM-LC-MS approach returned a greater number of lipid identifications, using DAPNe-LC-MS, certain diglycerides and triglycerides were more readily detected. Furthermore, it was found that DAPNe lipidomics can be used in sequence with elemental imaging, unlike LCM-LC-MS, which destroys the sample. This approach, DAPNe-PIXE, allowed the relationship between Fe and lipids to be probed in a TB granuloma.
description: Finally, the research described herein provided proof of concept for obtaining lipidomics profiles and measurement of anti-TB drugs in single cells."
Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)
Creators: name: Koestler, Devin C.
name: Jones, Meaghan J.
name: Usset, Joseph
name: Christensen, Brock C.
name: Butler, Rondi A.
name: Kobor, Michael S. (Geneticist)
name: Wiencke, John K.
name: Kelsey, Karl T.
Publisher: name: BioMed Central
Year: 2017

description: Background: Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, however the performance of such methods depends entirely on the library of methylation markers being used for deconvolution. Here, we introduce a novel algorithm for Identifying Optimal Libraries (IDOL) that dynamically scans a candidate set of cell-specific methylation markers to find libraries that optimize the accuracy of cell fraction estimates obtained from cell mixture deconvolution. Results Application of IDOL to training set consisting of samples with both whole-blood DNA methylation data (Illumina HumanMethylation450 BeadArray (HM450)) and flow cytometry measurements of cell composition revealed an optimized library comprised of 300 CpG sites. When compared existing libraries, the library identified by IDOL demonstrated significantly better overall discrimination of the entire immune cell landscape (p = 0.038), and resulted in improved discrimination of 14 out of the 15 pairs of leukocyte subtypes. Estimates of cell composition across the samples in the training set using the IDOL library were highly correlated with their respective flow cytometry measurements, with all cell-specific R 2>0.99 and root mean square errors (RMSEs) ranging from [0.97 % to 1.33 %] across leukocyte subtypes. Independent validation of the optimized IDOL library using two additional HM450 data sets showed similarly strong prediction performance, with all cell-specific R 2>0.90 and R M S E<4.00 %. In simulation studies, adjustments for cell composition using the IDOL library resulted in uniformly lower false positive rates compared to competing libraries, while also demonstrating an improved capacity to explain epigenome-wide variation in DNA methylation within two large publicly available HM450 data sets. Conclusions Despite consisting of half as many CpGs compared to existing libraries for whole blood mixture deconvolution, the optimized IDOL library identified herein resulted in outstanding prediction performance across all considered data sets and demonstrated potential to improve the operating characteristics of EWAS involving adjustments for cell distribution. In addition to providing the EWAS community with an optimized library for whole blood mixture deconvolution, our work establishes a systematic and generalizable framework for the assembly of libraries that improve the accuracy of cell mixture deconvolution.
Hausaufgaben: Probleme und Herausforderungen des philippinischen Bildungssystems
Creators: name: Romero Jr., Jose V.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Beobachter unseres Bildungssystems haben darauf hingewiesen, dass die rasche Ausweitung der Sekundarstufe wesentlich dazu beigetragen hat, das Niveau herab zu setzen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Reciprocal feedback between androgen receptor and protein synthesis machinery in prostate cancer
Creators: name: GALEANO-DALMAU, NÚRIA
Publisher: name: University of Surrey
Year: 2022

description: Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in men worldwide, with over 1.4 million new cases diagnosed in the year 2020. Androgen receptor (AR) and its signalling axis has critical role not only in development and maintenance of male sex characteristics, including the normal prostate development and function, but also as a key regulator of the PCa development and its progression to castration-resistant prostate cancer (CRPC), therefore the standard of care treatment functions by directly targeting androgens/AR signalling axis using the androgen deprivation therapy (ADT). Failure of ADT and subsequent development of CRPC, where therapeutic options are very limited and mostly palliative, pose a major challenge for patients and healthcare systems around the world. The progression of the PCa disease is characterised by an abnormally increased AR activity which could result from the dysregulation of AR-associated factors (AR-AFs). Here, by using qPLEX-RIME, a state-of-the-art targeted proteomics technology, we uncover an unexpected interaction between aminoacyl-tRNA synthetases (AARSs) machinery and the androgen signalling, in which a novel non-canonical function of AARSs directly modulates AR transcriptional activity, and in return AR modulates the function of AARSs. By studying the underlying mechanism and functional implications of the AR and Aspartate-tRNA synthetase (DARS), DARS was identified as an AR-regulated gene as well as a collaborative partner of the AR leading to increased function, suggesting a feedback loop between transcription and translation. The catalytic inhibition of DARS using an aspartate mimic destabilised the AR function and induced apoptosis in PCa cell lines. We propose a novel model to help to understand the role of AR as a connecting link between transcription and translation machinery, in which non-transcriptionally active cytosolic AR has a direct role in regulating translation by modulating the canonical function of DARS, and DARS regulating the nuclear AR function, and this represents a novel therapeutic target in the treatment of PCa.

description:

description: Conclusively, in this study, we have established novel reciprocal feedback between transcription and protein synthesis machinery through AR and AARSs in PCa, which could be exploited to open new treatment avenues for PCa patients.
Analyzing the top five destinations for international luxury travelers in Thailand
Creators: name: SIRIVADHANAWARAVACHARA, APHISAVADH
Publisher: name: Zenodo
Year: 2024

description: This eye-opening study by Associate Professor Dr. Aphisavadh Sriling investigates the new face of luxury tourism in Thailand, unveiling and investigating the top five destinations that attract high-net-worth international tourists. Drawing from qualitative and quantitative data, the article investigates the psychological, cultural, and economic motivations of luxury travel, unveiling the expectations, behaviors, and spending levels of discerning travelers seeking exclusivity, indulgence, and authenticity.Since Thailand is a top destination for luxury travel globally, the paper uncovers high correlations between aviation connectivity, tourist expenditure, and destination popularity. It provides a strategic blueprint for stakeholders in tourism and hospitality—particularly luxury hotels, tour operators, and policymakers—on how to better serve this elite market through elevated levels of service, customized experiences, and culturally immersive products.Packed with astute analysis and progressive suggestions, the book is a practical handbook to positioning Thailand as a competitive luxury tourism destination in the international market, while also promoting sustainable and high-value travel experiences. The research is particularly timely and topical in the context of post-pandemic travel resumption and increasing global demand for bespoke luxury experiences.
AI-Powered Campaign Management: The Future of Freelance Media Buying
Creators: name: Lacida, Hanzel
Publisher: name: Zenodo
Year: 2025

description: AI-Powered Campaign Management: The Future of Freelance Media Buying examines how artificial intelligence is transforming the way freelance media buyers manage digital advertising campaigns. It highlights how tools like Smart Bidding, automation scripts, and AI-driven creatives enable solo professionals to deliver agency-level results, scale operations efficiently, and stay competitive in a fast-evolving landscape. The paper also discusses benefits, risks, and the future outlook of AI as a virtual team for independent digital marketers.
Schwierige Kindheit: Über Kinderarbeit, Bildung und Gesetze für Kinder in den Philippinen
Creators: name: Foundation, IBON
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Die Gesellschaft schuldet ihren Kindern nicht weniger als das Beste, das sie geben kann — so die UN-Erklärung der Kinderrechte. Dieser Erklärung entsprechend behauptet die philippinische Regierung, eine kinderfreundliche Gesellschaft anzustreben. Ein Rahmenplan (Philippine National Strategie Framework for Plan Development for Children, 2000-2025) besagt, Kinder sollten "in Würde aufwachsen und sich entwickeln dürfen, geschützt vor Bedrohung ihres Wohlbefindens und frei, sich auszudrücken und ihre Entwicklung mit zu gestalten."
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Australia's asylum seeker policy and Christmas Island
Creators: name: Dimasi, Michelle Jasmin
Publisher: name: Swinburne
Year: 2024

description: Many political and media discussions make reference to Christmas Island, an Australian outpost located in the Indian Ocean, where asylum seekers are detained. While most mainland Australians only hear or read about asylum seekers via the media, the people of Christmas Island experience asylum seekers face to face. Drawing on ethnographic fieldwork conducted on Christmas Island from 2008 to 2011, this thesis tells the story of the Christmas Island host community. It examines what meaning can be made of islander and asylum seeker encounters and provides insights into how Australia’s asylum seeker policy plays out at the Australian border.
Eindrücke einer Reise: Zur politischen Situation in West Papua
Creators: name: Zöllner, Siegfried
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Im Mai und Juni 2002 war ich in West Papua. Als ich zurückkam, fand ich auf meinem Schreibtisch einen Artikel über West Papua mit dem Titel The Future may be Genocide vor (John Barr, Uniting Church Australia). Der Verfasser hatte wenige Wochen vor mir West Papua besucht. Viele seiner Gespräche und Informationen stimmten mit dem überein, was mir berichtet wurde und was ich selbst erlebte.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Investigating cognitive and ontological factors underlying the adherence to normative materialistic values and their influence on wellbeing
Creators: name: Elphinstone, Bradley
Publisher: name: Swinburne
Year: 2024

description: The results indicated that people who have a holistic, 'big picture' way of looking at the world, in combination with a complex, elaborative thinking style, place less importance on goals and aspirations associated with 'keeping up with the Joneses' and are less materialistic. These people are also motivated by meaningful, self-directed reasons rather than striving to impress others, and subsequently report greater self-esteem, self-actualization, and psychological wellbeing. The application of these findings can have a positive impact on mental health and the environment, through reducing extrinsically-motivated consumption.
Workshop #1: Open Access Publishing
Creators: name: Hanzlíková, Dagmar
name: Pauplin, Pascale
name: Riise, Rasmus Rindom
name: Procházková, Žaneta
Publisher: name: Zenodo
Year: 2025
Subjects: Open access
publishing
APC
copyright
diamond open access

description: This workshop invites participants to explore key issues in open access publishing, including the APC-based funding model and its consequences, challenges related to costs and copyright, and the rise of diamond open access. Participants will also be introduced to practical tools for researching publishers and journals.
Nachrichten
Creators: name: Arnez, Monika
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Frauen – eine Bestandsaufnahme
Creators: name: Findeisen, Genia
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Buchbesprechung von: Kathryn Robinson und Sharon Besell (ed.), Women In Indonesia, Gender, Equity and Development. ISEAS, Singapore, 2002, ISBN 981-230-158-5.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Cultural identity of Chinese students in a transnational university in China
Creators: name: RIBEIRO SEABRA EIRAS, PAOLA
Publisher: name: University of Surrey
Year: 2020

description: Higher education (HE)institutions play an important role in creating contexts for the development of identities. With respect to an increase in transnational education (TNE) within the Chinese HE environment over the last 10 to 15 years, the impact on individuals is under-researched. This thesis unpacks Chinese students’ experiences in a TNE environment in China which, in turn, impacted on constructions of their cultural identities. The fieldwork included 31 semi-structured, arts-based, face-to-face interviews with students at Xi’an Jiaotong-Liverpool University (XJTLU), and is grounded in double-analytical lenses: Interpretative Phenomenological Analysis and Discourse Analysis. Choosing XJTLU was a complex culturally-driven process, and seemingly the second best alternative among other domestic choices. The transition period from a Chinese educational system to XJTLU significantly impacted on the construction of participants’ personal and HE learner identities. Confucian values still form the fabric of Chinese social ethics, but new family values and relations are emerging. Articulation between students’ personal and cultural values, and their embodied self and agency, suggested potentially conflicting forces between values related to culture, educational backgrounds, and desired identities. The relevance of TNE in China in shaping cultural identities of Chinese students relates to the importance of individual and cultural processes impacting on students’ transforming self-perceptions and experiences. Students need to relate to themselves (as HE students) with: their peers, international academic staff, English as a medium of instruction use and how they feel they are perceived by others. This ongoing process of identity construction may have a profound impact on how these students see themselves as HE students and Chinese youth, and their place in the world into the future, and by extension on the way China as a nation will image itself in its engagement with the rest of the world, particularly in a post-COVID-19 era.
Paraamblyptilia eutalanta
Creators: name: Ustjuzhanin, Petr
name: Kovtunovich, Vasyly
name: Pototski, Aleksander
name: Nupponen, Kari
name: Haverinen, Risto
name: Streltzov, Alexander
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Pterophoridae
Paraamblyptilia
Paraamblyptilia eutalanta

description: Paraamblyptilia eutalanta (Meyrick, 1931)
 Material examined. 1 male, 2 females, CHILE, Andes Mts., Valle Nevado, Los Condores, 06.ii.2017, 33°21'S, 70°17'W, 2420 m, K. Nupponen & R. Haverinen leg. (IZBE, CUK).
description: Published as part of Ustjuzhanin, Petr, Kovtunovich, Vasyly, Pototski, Aleksander, Nupponen, Kari, Haverinen, Risto & Streltzov, Alexander, 2021, Two new species of plume moths (Lepidoptera: Pterophoridae) from Atacama Desert (Chile), pp. 16-23 in Ecologica Montenegrina 45 on page 21, DOI: 10.37828/em.2021.45.4, http://zenodo.org/record/13233910
Kompetenz ist gefragt – Schulreform in Indonesien: Schulen im Prozess der Dezentralisierung
Creators: name: Arnez, Monika
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Bildung stellt seit jeher ein schwerwiegendes Problem innerhalb des indonesischen Archipels dar. Viele Kinder erhalten nur eine minderwertige schulische Ausbildung, was ihnen die spätere Arbeitssuche erschwert. Seit der Wirtschaftskrise gehen auch viele Kinder der unteren Schichten gar nicht mehr zur Schule, da die Eltern das Schulgeld nicht aufbringen können. Das Bildungsministerium setzt die Schulreform jedoch nicht bei diesen grundlegenden Problemen an. Stattdessen hat es ein neues Kurrikulum für säkulare Grundschulen und Gymnasien beschlossen. Dieses soll nicht mehr, wie bisher üblich, inhaltsbezogen sein, sondern auf Kompetenz basieren.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Understanding the ageing brain: Are age-related memory changes associated with theta power?
Creators: name: GOLDTHORPE, ROBIN ALEXANDER
Publisher: name: University of Surrey
Year: 2021
Subjects: Ageing
Older adults
Memory
Theta
EEG
Oscillation
Power
Encoding

description: Memory changes are commonplace over the lifespan. With advances in neuroimaging there is accumulating evidence that changes in neural dynamics may underscore changes in memory functioning. Oscillations in the theta range have long been associated with memory processes. However, how theta activity might relate to the ageing brain, and more specifically the losses in memory thought to occur during the ageing process, is less clear. This research aimed to explore these questions by analysing a large dataset of 227 adult participants from across the lifespan. Memory was assessed across different domains (episodic, associative, and working memory), and was compared with participants underlying resting-state electroencephalography (EEG). Older participants displayed significant losses in memory performance across all memory domains, as well as decreased theta power across frontal, medial parietal, and occipital regions. Amongst younger participants working memory correlated with theta power in medial frontal, left temporal, and right temporoparietal regions, however this effect was lost amongst older adults. These findings suggest that resting theta power diminishes over the lifespan in numerous cortical regions, which corresponds with a decline in memory performance. Moreover, these findings suggest a nuanced relationship between working memory and theta power, providing evidence of a unique association between theta power and working memory performance only amongst younger adults. Taken together, resting-state EEG measures appear to carry promise in understanding the nature of neurodynamic changes over the lifespan, with theta functioning dynamically changing as a function of age. Whilst this study is limited by its cross-sectional and correlational design, future longitudinal and causational research, possibly using non-invasive brain stimulation, would help clarify the effects observed.
Nachrichten
Creators: name: Jordan, Rolf
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Adherence to interferon β-1a therapy using an electronic self-injector in multiple sclerosis: a multicentre, single-arm, observational, phase IV study
Creators: name: Devonshire, Virginia A
name: Feinstein, Anthony
name: Moriarty, Patrick
Publisher: name: BioMed Central
Year: 2018

description: Background: In a multicentre, single-arm, observational, phase IV study, we evaluated 24-week treatment adherence of relapsing multiple sclerosis (RMS) patients using an electronic auto-injection device (RebiSmart®) for subcutaneous injection of interferon (IFN) β-1a. Methods: A total of 162 adult participants with RMS were enrolled into the study to use RebiSmart® to self-administer IFN β-1a 44 μg three times weekly for a maximum of 96 weeks. The number of administered injections was recorded in the electronic device log. Adherence to treatment was defined as the administration of ≥80 % of expected injections. Cognitive impairment and injection anxiety were assessed via questionnaires. Results: Overall, 91.8 and 82.9 % of participants were adherent to treatment at weeks 12 and 24, respectively. By weeks 12 and 24, 8.2 and 13.9 % of participants had discontinued treatment. There were no statistically significant differences in adherence rates at weeks 12 and 24 according to cognitive impairment status or injection anxiety. By week 24, 69.9 % of participants were less fearful of injection than when they started the study. According to participant evaluations, the absence of a visible needle, comfort settings, and the calendar for tracking the injection schedule were all important features of the RebiSmart® injection system. At week 24, 99.3 % of participants reported that they would like to continue using RebiSmart® as their injector. Conclusions: RebiSmart® use is associated with high treatment adherence, as objectively assessed using electronic injection logs. Future research should examine if RebiSmart® use improves long-term treatment outcomes in RMS. This study was registered with ClinicalTrials.gov as NCT01128075, on May 20, 2010.
Treatment of prescription opioid disorders in Canada: looking at the ‘other epidemic’?
Creators: name: Fischer, Benedikt
name: Kurdyak, Paul
name: Goldner, Elliot
name: Tyndall, Mark
name: Rehm, Jürgen
Publisher: name: BioMed Central
Year: 2018

description: The magnitude and consequences of prescription opioid (PO) misuse and harms (including rising demand for PO disorder treatment) in Canada have been well-documented. Despite a limited evidence-base for PO dependence treatment, opioid maintenance therapy (OMT) - mostly by means of methadone maintenance treatment (MMT) - has become the de facto first-line treatment for PO-disorders. For example in the most populous province of Ontario, some 50,000 patients - large proportions of them young adults - are enrolled in MMT, resulting in a MMT-rate that is 3–4 times higher than that of the United States. MMT in Ontario has widely proliferated towards a quasi-treatment industry within a system context of the public fee-payer offering generous incentives for community-based MMT providers. Contrary to the proliferation of MMT, there has been no commensurate increase in availability of alternative (e.g., detox, tapering, behavioral), and less intrusive and/or costly, treatments which may provide therapeutic benefits at least for sub-sets of PO-dependent patients. Given the extensive PO-dependence burden combined with its distinct socio-demographic and clinical profile (e.g., involving many young people, less intensive or risky opioid use), an evidence-based ‘stepped-care’ model for PO dependence treatment ought to be developed in Canada where MMT constitutes one, but likely a last resort or option, for treatment. Other, less intrusive treatment options as well as the best mix of treatment options should be systematically investigated and implemented. This case study has relevance and implications for evidence-based treatment also for the increasing number of other jurisdictions where PO misuse and disorders have been rising.
Das Stadium der nackten Existenznot ist lange vorbei: Doch was kommt jetzt für die Kinder und Jugendlichen in Singapur?
Creators: name: Kieserling, Manfred
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nun ist das ja in Singapur nicht so, dass Kinder dort in muffigen, finsteren Hinterhofstuben T-Shirts zusammennähen müssen für Reiche, die bereits fast alles haben, aber meinen, am Hemd sparen zu müssen. So ist es anderenorts, ob in Bangkok, Mexiko City oder sonst wo; wie es auch woanders stattfindet, dass Kinder ihre Körper hingeben müssen für euphemistisch so genannte Sextouristen. Solche Formen der Verluderung, der Vergewaltigung und Ausbeutung der eigenen Kinder gibt es nicht (mehr) in der Inselrepublik. Ob aber das, was dann kommt, >besser< ist, oder einfach nur anders, wird man fragen müssen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien