cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Protein homeostasis regulation in amyotrophic lateral sclerosis
Creators: name: Montibeller, Luigi
Publisher: name: Imperial College London
Year: 2020

description: Amyotrophic lateral sclerosis (ALS) is a disorder that affects motor neurons in the motor cortex, brainstem and spinal cord. The lack of an effective treatment indicates the need for a deeper understanding of the pathogenesis underlying this disease. ALS, as well as the majority of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are characterised by dysfunctions in protein homeostasis (proteostasis). The endoplasmic reticulum (ER) plays an important role in proteostasis through the unfolded protein response (UPR). We therefore started this thesis by characterising the UPR signalling pathways in human post-mortem spinal cord from sporadic ALS (SALS) and in frontal and temporal cortex from FTLD and AD cases and compared with healthy controls. In ALS, UPR activation was confirmed by a substantial expression increase of both known and novel target genes involved particularly in ER-associated degradation (ERAD), while in AD a distinct pattern emerged, with a predominant involvement of protein folding genes, such as Protein Disulphide Isomerases (PDIs). Similarly, in human motor cortex of SALS cases we found an increased expression of PDIs and other specific UPR target genes which correlated with oligodendrocyte markers. Moreover, we found that the heat shock response (HSR), a major proteostasis regulatory pathway, and ERAD genes were activated predominately in the spinal cord and strongly correlated with the motor neuron marker VAPB. Finally, we performed a meta-analysis of publicly available RNA-Seq studies derived from the spinal cord of healthy and ALS cases. We identified cholesterol metabolism, cell adhesion and regulation of vesicle-mediated transport as top disease-associated processes and 21 hub genes as central nodes in these networks. We conclude that proteostasis is strongly and selectively activated specific cell types in SALS motor cortex and spinal cord. Hence, these results provide novel insights into the pathophysiology of ALS and other neurodegenerative disorders.
Optimisation of scheduling and routing for offshore wind farm maintenance
Creators: name: Kingsman, Toby
Publisher: name: Lancaster University
Year: 2020

description: The growing increase in the size and scope of offshore wind farms motivates the need for industry to have access to mathematical tools that reduce costs by efficiently performing daily operations and maintenance activities. Key offshore activities require the transportation of technicians to and within offshore wind farms to complete corrective and preventive maintenance tasks to keep turbines operating efficiently. We provide a new deterministic mixed integer linear programming formulation for deciding the optimal vessel routes for transporting technicians around a wind farm and the scheduling of crew transfers, by minimising downtime, travel and technician costs. The model contains sufficient flexibility to account for multiple vessels, shifts and task profiles, whilst being able to prioritise and omit tasks in environments containing limited resources. Computational experiments are performed which quantify and confirm the impact of key instance characteristics such as technician availability, task profiles and weather conditions. We implement and evaluate the impact of a novel industry safety constraint. The complexity of larger instances motivates a second continuous time formulation, in which preventive maintenance again requires no minimum duration of work before it can provide benefit. We employ a specific decomposition structure to take advantage of variable preventive maintenance and utilise an adaptive large neighbourhood search procedure to solve instances. We evaluate several distinct acceptance criteria in conjunction with random and adaptive operator selection to determine the best option for our model. We produce a statistical model of offshore weather conditions to help quantify the likelihood of limited vessel accessibility to offshore wind farms. We model the joint distribution of key meteorological and oceanographic variables over time whilst accounting for seasonal trends using multivariate kernel density estimation. Our method generates alternative metocean realisations from historical data and reproduces the important long term persistence statistics of good and adverse offshore conditions.
Allotropa Forster 1856
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Allotropa

description: Genus Allotropa Förster, 1856
Allotropa Förster, 1856: 106, 109.
Type species Inostemma mecrida Walker, 1835 by monotypy.
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Investigating the biology of SOX17 in pulmonary arterial hypertension
Creators: name: Walters, Rachel
Publisher: name: Imperial College London
Year: 2022

description: Pulmonary arterial hypertension (PAH) is a rare disease characterised by remodelling of the pulmonary arteries and increased vascular resistance. A genome wide association study (GWAS) of idiopathic/heritable PAH established novel genetic associations. This GWAS identified a novel genomic locus upstream of the SOX17 gene promoter containing two independent signals inside a putative enhancer region. Sox17 is an important transcription factor in human pulmonary artery endothelial cells (hPAECs) and rare pathogenic mutations in SOX17 have previously been linked to PAH. There is allele-specific transcription factor (TF) binding at the enhancer region upstream of SOX17 and PAH-associated variation in this region affects SOX17 expression, hPAEC function and PAH development. This thesis aims to define the TFs binding at the SOX17 locus and downstream pathways and functional changes regulated by Sox17. Also, to explore how SOX17 expression and function can be rescued by novel compounds. Electromobility shift assay (EMSA) have been used to identify TFs which differentially bind to the enhancer locus present upstream of SOX17. These assays have demonstrated differential binding of hPAECs nuclear proteins to the risk and non-risk alleles from a SOX17 GWAS signal. ROR-alpha, has been identified through in silico analysis and antibody supershift assays to be potentially responsible for this binding. siRNA and CRISPR-Inhibition have been used to manipulate SOX17 and the PAH associated loci to determine downstream genes and pathways affected by SOX17 manipulation. Inhibition of a GWAS signal upstream of SOX17 decreases SOX17 expression. Manipulation of SOX17 expression affects PAH-relevant pathways and functions in hPAECs. In-silico analysis has been used to predict compounds which rescue SOX17 dysfunction. Multiple candidate compounds have been tested and show a reversal of gene changes induced by SOX17 in hPAECs. The PAH GWAS signal is now confirmed as an active enhancer site that regulates SOX17, a TF that regulates PAH-relevant pathways and functions in hPAECs. Novel compounds may be able to rescue these functions through restoration of downstream SOX17 targets, and thus be candidates for the treatment of PAH
Introducing D-CRAFT webinar slides
Creators: name: Morales, Myrna
name: Thompson, Santi
name: Chapman, Joyce
name: Jefferson, Derrick
name: Woolcott, Liz
name: Shiri, Ali
name: Ranti Junus
name: Kenfield, Ayla Stein
name: Hennig, Nicole
name: Kelly, Elizabeth Joan
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: D-CRAFT
subject: content reuse
subject: reuse assessment
subject: digreuse

description: Presentation slides for the webinar 'Introducing D-CRAFT: A Toolkit for Assessing Reuse of Digital Objects in Your Collections'
Acerotella evanescens
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Acerotella
Acerotella evanescens

description: Acerotella evanescens (Kieffer, 1914)
Acerota evanescens Kieffer, 1914: 369–371. Type locality: Germany, Aachen.
Acerotella evanescens – Masner 1964: 148. — Awad et al. 2023b: 5, fig. 1 (lectotype designation).
Material examined
Lectotype GERMANY • 1 ♀ (right of pin); Aachen; A. Förster leg.; NHMW-HYM#0005406.
Paralectotypes GERMANY • 1 ♀ (same pin as lectotype); same data as for lectotype; NHMW-HYM#0005406 • 2 ♀♀; same data as for lectotype; NHMW-HYM#0005405 • 6 ♂♂; same data as for lectotype; NHMW-HYM#0005407.
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on pages 3-4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Eggs, hatching and embryos variability in Loggerhead sea turtle Caretta caretta show significant differences among nests coming from two Italian nesting grounds
Creators: name: Zuffi, Marco Alberto Luca
name: Bollaro, Luna
name: Mancusi, Cecilia
name: Marsili, Letizia
name: Nicolosi, Paola
name: Raimondi, Giovanni
name: Terracciano, Giuliana
name: Caruso, Chiara
name: Tonelli, Laura
name: Venturi, Lucia
name: Mingozzi, Toni
Publisher: name: Brill Online
Year: 2023
Subjects: Ecology not elsewhere classified

description: Analysis of embryonic asymmetry may inform on pathologies, metabolic deficiencies or on functional anomalies. In Chelonians, range and relative numbers of abnormalities that occur at the embryonic stages are poorly known. The relative importance of the abnormalities causing embryonic death in the context of the conditions of incubation is not known. As for Caretta caretta, very little information is available on the biometry and anomalies of dead embryos in the Mediterranean basin. We compared data on biometric variability of carapace length and width, flippers asymmetries, clutch size, and hatching success from nests of Loggerhead coming from: the Ionian Calabrian coast (Southern Italy), where nesting has longly documented, and the Northern Tyrrhenian coast (Tuscany, Central Italy), where nesting activity has started only recently. Dead embryos were found inside nests after hatchling emergence. The turtles that nested in the two areas laid similar clutch sizes, but the Northern Tyrrhenian coast shows less hatched eggs and a lower hatching success, higher number of dead embryos and of unhatched eggs. Embryos from the Northern Tyrrhenian coast were significantly smaller than the Ionian Calabrian ones. Estimated stages ranged from 26 to 31b in both regions, stages 29-31b were more abundant in the Ionian Calabrian. Left vs right fore-flipper length varied significantly, with left flipper being longer than right flipper, but this asymmetry did not differ between the two regions. Flipper asymmetry seems to be a shared pattern in both juvenile and adult stages, likely not being the cause of mortality of our studied embryos.
title: Student Adoption Of Facebook Private Groups For Mobile Learning In Hong Kong
Creators: name: Lam, L
Publisher: name: London South Bank University
Year: 2018

description: Mobile learning using Facebook is increasingly used by faculty in universities to improve student engagement. This study examines the determinants influencing students’ acceptance of Facebook for mobile learning. Seven determinants were identified in past literature, including: performance expectancy, effort expectancy, device usability, hedonic motivation, habit, social presence and interactive learning. A research model was developed in order to explain students’ behavioral intention to use Facebook private study groups for mobile learning. The model was empirically tested using the survey data collected from students (N=123) of a marketing course taught using mobile learning in a classroom setting. It was followed by focus group interviews for triangulation and further exploration based on student feedback and comments. Research findings confirmed that all seven determinants had significant positive associations with the behavioral intention to use Facebook private study groups for mobile learning. Hedonic motivation had the most significant positive association with the students’ behavioral intention. In addition, it was found that social norms played an important role in influencing student use behavior. The findings of this research provide insights into (1) the theory and practice in the successful implementation of mobile learning using Facebook, (2) blended pedagogical strategies in confronting the continuous technology innovation and changing learning preferences of a new generation of students and (3) management strategies in mobile learning.
New experimental and computational methods for ultrasound brain tomography
Creators: name: Cueto Mondejar, Carlos
Publisher: name: Imperial College London
Year: 2021

description: Fast, portable, and affordable neuroimaging is currently unavailable in clinical practice, hindering prevention and treatment of pathologies such as stroke, a leading cause of death and disability worldwide. Full-waveform inversion (FWI), an ultrasound-based tomographic technique, has been recently proposed as a solution to this problem, but is yet to be successfully applied experimentally. Two fundamental barriers hinder its experimental application: a lack of numerical models that accurately replicate experimental measurements, and of domain-specific software that implements FWI algorithms efficiently. Here, I address both problems, opening the door to universally available neuroimaging. Addressing the first barrier entails finding numerical models that can explain the behaviour of the acquisition system: the transmission and reception response of the transducers, and their spatial location and orientation. As I demonstrate here, existing position-estimation methods fail when the surface of the transducers is bigger than the wavelength, a prerequisite for imaging through the skull, while available response-estimation techniques cannot achieve the precision required by full-wave methods. Therefore, I present spatial response identification, a new algorithm for transducer calibration and modelling, and show how it can be used to explain experimental devices with higher accuracy than existing methods. Additionally, I present experimental reconstructions of a tissue-mimicking phantom, achieving improved imaging quality with respect to standard calibration techniques. The second barrier stems from the fact that FWI is mathematically challenging and orders of magnitude more computationally expensive than conventional ultrasound imaging, while there is an absence of open codes, slowing the pace of research and hindering reproducibility. Therefore, I introduce Stride, an open-source Python library that combines high-level interfaces with automatically generated, high-performance solvers and scalable parallelisation. Here, I demonstrate that Stride can achieve state-of-the-art modelling accuracy and how it can be used to image in 2D and 3D, scaling from a local workstation to a high-performance cluster.
title: Cittadinanza e non lavoro per la democrazia del terzo millennio
Creators: name: Forcina , Marisa
Publisher: name: Roma Tre-Press
Year: 2007

description: Nel presente contributo si delinea il concetto di lavoro di Hannah Arendt, e il suo significato rispetto alla vita activa, passando per numerosi altri autori, quali Weber, Polanyi, Marx.

description: B@belonline vol. 3 L’eredità di Hannah Arendt
Additional file 3 of Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
Creators: name: Rossi, Alessandro
name: Assunto, Antonia
name: Rosano, Carmen
name: Tucci, Sara
name: Ruoppolo, Margherita
name: Caterino, Marianna
name: Pirozzi, Francesca
name: Strisciuglio, Pietro
name: Parenti, Giancarlo
name: Melis, Daniela
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 3: Supplemental figure 3.FAO enzymes in GSDIa children. FAO enzyme activity is presented as % activity compared to the mean calculated on a pool of healthy subjects.Citrate synthase activity in GSDIa childrenand healthy controls. For all proteins mean value is shown for each group of participants. C1: pediatric controls who had blood collection after the same fasting time as their matched patients.
title: A light in the dark: using cabled seafloor observatories to study abundance and behaviour of seafloor megafauna in response to environmental change
Creators: name: Command, Rylan J.
Publisher: name: Memorial University of Newfoundland
Year: 2023

description: Surface primary productivity forms the base of most marine food webs and contributes significantly to global carbon cycling, providing a key link from surface to seafloor. High seasonal primary productivity along temperate latitude coastlines provides crucial nutrients for seafloor communities, driving spatiotemporal patterns in abundance, behaviour, biodiversity, and distribution of benthic megafauna. Many factors, including ocean warming, deoxygenation, and increasing frequency and duration of marine heatwaves (MHW), may alter the dynamics governing primary production, threatening benthic organisms that depend on the seasonal input of phytodetritus for food. The focus of this thesis is to make use of two seafloor observatories, NEPTUNE near Vancouver Island, British Columbia, and a new platform in Conception Bay, NL, to examine variability in abundance, behaviour, and composition of seafloor communities in response to environmental change across temporal scales. First, the response of the deep-sea pink urchin Strongylocentrotus fragilis to a recent MHW on the continental margin off the coast of Vancouver Island was investigated using a combination of benthic trawls (2004-2018) and seafloor observatory data (2013-2020). Sea urchin density declined during the MHW, likely in response to reduced kelp subsidies from coastal waters. Next, the new Holyrood Underwater Observatory in Conception Bay was used to study benthic community response to the spring phytoplankton bloom. High-frequency variability in seafloor environmental dynamics was documented during the winter-spring transition, and the unexpected emergence of >200 sea cucumbers (Psolus sp.) coinciding with the arrival of phytodetritus at the seafloor was observed. These data will provide a baseline against which to monitor changes in phenology as climate change progresses. This work comes at a critical point in ocean observing as we approach global climate tipping points. Now more than ever, it is essential to document the current state of marine communities to understand and predict community responses to changing ocean conditions, and to sustainably manage ocean resources.
title: Human and environmental exposure to hydrocarbon pollution in the Niger Delta
title: A geospatial approach
titleType: Subtitle
Creators: name: Obida, Christopher Basharu
Publisher: name: Lancaster University
Year: 2020

description: This study undertook an integrated geospatial assessment of human and environmental exposure to oil pollution in the Niger Delta using primary and secondary spatial data. This thesis begins by presenting a clear rationale for the study of extensive oil pollution in the Niger Delta, followed by a critical literature review of the potential application of geospatial techniques for monitoring and managing the problem. Three analytical chapters report on the methodological developments and applications of geospatial techniques that contribute to achieving the aim of the study. Firstly, a quantitative assessment of human and environmental exposure to oil pollution in the Niger Delta was performed using a government spill database. This was carried out using Spatial Analysis along Networks (SANET), a geostatistical tool, since oil spills in the region tend to follow the linear patterns of the pipelines. Spatial data on pipelines, oil spills, population and land cover data were analysed in order to quantify the extent of human and environmental exposure to oil pollution. The major causes of spills and spatial factors potentially reinforcing reported causes were analysed. Results show extensive general exposure and sabotage as the leading cause of oil pollution in the Niger Delta. Secondly, a method of delineating the river network in the Niger Delta using Sentinel-1 SAR data was developed, as a basis for modelling potential flow of pollutants in the distributary pathways of the network. The cloud penetration capabilities of SAR sensing are particularly valuable for this application since the Niger Delta is notorious for cloud cover. Vector and raster-based river networks derived from Sentinel-1 were compared to alternative river map products including those from the USGS and ESA. This demonstrated the superiority of the Sentinel-1 derived river network, which was subsequently used in a flow routing analysis to demonstrate the potential for understanding oil spill dispersion. Thirdly, the study applied optical remote sensing for indirect detection and mapping of oil spill impacts on vegetation. Multi-temporal Landsat data was used to delineate the spill impact footprint of a notable 2008 oil spill incident in Ogoniland and population exposure was evaluated. The optical data was effective in impact area delineation, demonstrating extensive and long-lasting population exposure to oil pollution. Overall, this study has successfully assembled and produced relevant spatial and attribute data sets and applied integrated geostatistical analytical techniques to understand the distribution and impacts of oil spills in the Niger Delta. The study has revealed the extensive level of human and environmental exposure to hydrocarbon pollution in the Niger Delta and introduced new methods that will be valuable for
Why the 21st Century needs more idealism in science and science policy
Creators: name: Policy Labs, Frontiers
name: Morgan, Ruth
Publisher: name: Frontiers
Year: 2023
Subjects: Uncategorized

description: We need more idealism in science and science policy to find solutions to challenges. If we restrict ourselves to what is tangible, known and established today, there is a risk that possible solutions to ‘wicked’ challenges that contribute to enriched and thriving individuals, societies, and their natural ecosystems could be missed. But if we ask, ‘what if?’, we introduce a capacity for idealism that opens up opportunities for creative critical thinking and imagination.
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title: Managing Project Sustainability:
A Study of the Construction Industry in
Hong Kong
Creators: name: Tam, G C K
Publisher: name: London South Bank University
Year: 2018

description: Despite the vast research on project success and sustainability, little is known about managing
project sustainability, particularly Hong Kong’s construction industry. Previous empirical
studies on construction project implementation success lack the ingredients of sustainability.
This sequential mixed methods research explores such a relationship from both project
maturity and process perspectives. The quantitative study on local construction project
managers identifies the status quo of project sustainability maturity. In addition, it identifies
sustainability success criteria and factors attributable to project implementation success. The
quantitative study results generate question for a subsequent qualitative e-Delphi study. The
follow-up e-Delphi study distinguishes the degree of impact related to economic
sustainability, environmental sustainability, and social sustainability on construction projects.
This study surveyed 55 local construction project managers and received consensus from 12
international experts in the field. First, the mixed methods study found that a discernible
construction project sustainability maturity level does not appear in the Hong Kong
construction industry. However, organisations generally value project sustainability. Second,
the study found four traditional success criteria to explain a majority of local construction
project implementation success. Third, two significant sustainability impact criteria
(economic and environmental constructs) contributed to local construction project
implementation success. However, criterion representing social sustainability impact was not
identified. Fourth, the traditional constituent success criterion for construction project
implementation success linked to certain sustainability impact elements. Fifth, the study
categorised important sustainability impact-related factors (economic: 3; environmental: 4;
and social: 3). Finally, e-Delphi experts believed that environmental sustainability was more
important than economic and/or social sustainability. This study contributes knowledge to researchers in the field. It also provides local construction project managers with management
practices in structuring sustainability-related success criteria and factors contributing to
project implementation success. Limitations of this study include not able to conduct
longitudinal study, limited judgmental sample size in the survey, clients and stakeholders’
view not being considered in the quantitative study, and that majority of the e-Delphi experts
in the qualitative study are not base in Hong Kong, etc. Such limitations may reduce the
reliability of the research findings.
title: The Role of the Expatriate Business Community
in Rebuilding a State After Forced Failure
A Case Study of Iraq
Creators: name: AlSadi, M
Publisher: name: London South Bank University
Year: 2018

description: More than 14 years after the U.S.-led invasion and the collapse of the state in 2003 Iraq’s performance in social and physical reconstruction remains poor and hindered by numerous obstacles. The political culture in Iraq particularly suffers from excessive foreign influence, extreme corruption and self-serving political culture, exacerbating social problems in a now-heavily divided society.
Long-established power blocs are heavily entrenched within a sectarian division of power in Iraqi governance and independent actors including the Iraqi expatriates, the private sector and civil society groups are heavily impeded from introducing change to the established order.
This thesis reviews the background and progress of Iraqi reconstruction efforts since 2003 to highlight factors that contribute to this situation. It uses existing Iraq-specific literature to highlight spaces where alternative political and civil society actors could help change the country’s political culture. Comparative examples from other post-conflict societies (including Lebanon, Afghanistan and Germany) are used to show how expatriate communities, particularly those involved in private enterprise can contribute to post-conflict reconstruction and improving governance in failed or fragile states. The researcher’s extensive personal experience and a case study of the Iraqi Business Council in Jordan comprise the majority of primary research.
Comparative case studies show that the private sector capabilities and the international experience gained by expatriates can contribute positively to the reconstruction of their war-torn societies. The thesis highlights opportunities to increase the input of these expatriate business communities in reconstructing Iraq.
With the war on ISIS now subsiding, Iraq faces a new chapter of challenges mainly in reconciliation, reinstating refugees, rebuilding an investment-based economy, fighting corruption and injustice. All these major challenges require sincere and genuine effort to engage the business community inside and outside Iraq. Therefor the importance of this thesis comes from its focus on the above challenges.
Allotropa mecrida
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Allotropa
Allotropa mecrida

description: Allotropa mecrida (Walker, 1835)
Inostemma mecrida Walker, 1835: 273. Type locality: England, near London.
Allotropa mecrida – Förster 1856: 109. — Vlug & Graham 1984 (lectotype designation).
Material examined
Lectotype [ENGLAND] • 1 ♂; [A. Haliday leg.]; original exemplar; NHMW-HYM#0005310.
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Additional file 4 of Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
Creators: name: Rossi, Alessandro
name: Assunto, Antonia
name: Rosano, Carmen
name: Tucci, Sara
name: Ruoppolo, Margherita
name: Caterino, Marianna
name: Pirozzi, Francesca
name: Strisciuglio, Pietro
name: Parenti, Giancarlo
name: Melis, Daniela
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 4: Supplemental figure 4. Correlation analysis in adult GSDIa patients.Correlation between VLCAD activity and waist circumferenceand BMI.Correlation between VLCAD activity and ACLY mRNA levels.Correlation between citrate synthase activity and ACLY mRNA levels. * p< 0.05.
Amblyaspis Forster 1856
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Amblyaspis

description: Genus Amblyaspis Förster, 1856
Amblyaspis Förster, 1856: 107, 112. Type species Platygaster tritici Walker, 1835 by subsequent designation by Vlug (1995: 12).
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Clinical Decision Support System for Unani Medicine Practitioners
Creators: name: Sultan, Haider
name: Mahmood, Hafiza Farwa
name: Fatima, Noor
name: Nadeem, Marriyam
name: Waheed, Talha
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Like other fields of Traditional Medicines, Unani Medicines have been found as an effective medical practice for ages. It is still widely used in the subcontinent, particularly in Pakistan and India. However, Unani Medicines Practitioners are lacking modern IT applications in their everyday clinical practices. An Online Clinical Decision Support System may address this challenge to assist apprentice Unani Medicines practitioners in their diagnostic processes. The proposed system provides a web-based interface to enter the patient's symptoms, which are then automatically analyzed by our system to generate a list of probable diseases. The system allows practitioners to choose the most likely disease and inform patients about the associated treatment options remotely. The system consists of three modules: an Online Clinical Decision Support System, an Artificial Intelligence Inference Engine, and a comprehensive Unani Medicines Database. The system employs advanced AI techniques such as Decision Trees, Deep Learning, and Natural Language Processing. For system development, the project team used a technology stack that includes React, FastAPI, and MySQL. Data and functionality of the application is exposed using APIs for integration and extension with similar domain applications. The novelty of the project is that it addresses the challenge of diagnosing diseases accurately and efficiently in the context of Unani Medicines principles. By leveraging the power of technology, the proposed Clinical Decision Support System has the potential to ease access to healthcare services and information, reduce cost, boost practitioner and patient satisfaction, improve speed and accuracy of the diagnostic process, and provide effective treatments remotely. The application will be useful for Unani Medicines Practitioners, Patients, Government Drug Regulators, Software Developers, and Medical Researchers.
description: 59 pages, 11 figures, Computer Science Bachelor's Thesis on use of Artificial Intelligence in Clinical Decision Support System for Unani Medicines
Additional file 5 of Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
Creators: name: Rossi, Alessandro
name: Assunto, Antonia
name: Rosano, Carmen
name: Tucci, Sara
name: Ruoppolo, Margherita
name: Caterino, Marianna
name: Pirozzi, Francesca
name: Strisciuglio, Pietro
name: Parenti, Giancarlo
name: Melis, Daniela
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 5: Supplemental figure 5. Correlation between ACLY mRNA levels and serum ASTand ALT. *p< 0.05; **p< 0.01.
Amblyaspis forticornis
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Amblyaspis
Amblyaspis forticornis

description: Amblyaspis forticornis (Nees, 1834)
Platygaster forticornis Nees, 1834: 308. Type locality: Germany, Sickershausen.
Amblyaspis forticornis – Vlug 1973: 180. — Awad et al. 2023b: 7, fig. 3 (neotype designation).
Material examined
Neotype [GERMANY] • 1 ♀; original exemplar; NHMW-HYM#0005324.
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Isocybus Forster 1856
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Isocybus

description: Genus Isocybus Förster, 1856
Isocybus Förster, 1856: 108, 114–115. Type species Platygaster grandis Nees, 1834 by subsequent designation by Ashmead (1893: 327).
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 5, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
title: Dynamic maximum power point tracking and robust voltage regulation for photovoltaic systems
Creators: name: Kahani, Rasool
Publisher: name: Memorial University of Newfoundland
Year: 2023

description: This research proposes a Maximum Power Point Tracking (MPPT) and voltage regulation method based on model reference adaptive control (MRAC). The MPPT algorithm which is presented in this work is a modified perturb and observe (P&O) algorithm. The new algorithm prevents oscillation around maximum power point (MPP) by approximating the peak of photovoltaic (PV) array power curve. This goal is achieved by comparing the change in output power during each cycle with change in array terminal power during the previous cycle. When array terminal power decreases following an increase in the previous cycle or the opposite, a decrease in array terminal power is followed by an increase, it means the power curve has reached its peak. Therefore, the duty cycle of the boost converter should remain the same. When irradiance changes, the proposed technique produces an MPPT algorithm's average efficiency ( MPPT  ) of nearly 3.1 percent greater than the conventional P&O and the Incremental conductance (InC) algorithm. In addition, under strong partial shading conditions (PSC) and drift avoidance tests, the proposed technique produces an average MPPT  of nearly 9 percent and 8 percent greater than the conventional algorithms, respectively. To inject the generated PV power into the grid with high quality, this work designs voltage regulation controller based on MRAC to ensure the output voltage of the PV system is at the desired level. To achieve this goal, we propose a DC–DC boost converter that stabilizes output voltage variations by using MIT rule controllers. An output voltage is stabilized using two control loops, PID controllers are capable of regulating output voltage at fixed levels, and for the outer loop, it's intended to implement the direct model reference adaptive controller (DMRAC) MIT rule. In comparison with DC–DC boost converters connected to the micro-grid (MG), the controller presented here, manages disturbances and unknown parameter fluctuations more effectively. The proposed controller and the model are tested in MATLAB/SIMULINK for load disturbances. The load was changed by ~50% of its original value, and the worst-case settling time and maximum overshoot were less than ~0.1 s and 0.5 V (0.3%), respectively. Comparison with the PID methods, the lowest overshoot among three different PID tuning methods, namely the Ziegler–Nichol’s frequency-domain method, damped oscillation method, and Good Gain method, is 34%. Therefore, it is evident from results that the proposed algorithm has better performance in dealing with the maximum overshoot issues. The hardware validation is also carried out to show the performance of the proposed controller.
A Multilingual Virtual Guide for Self-Attachment Technique
Creators: name: Law, Alicia Jiayun
name: Hu, Ruoyu
name: Alazraki, Lisa
name: Gopalan, Anandha
name: Polydorou, Neophytos
name: Edalat, Abbas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In this work, we propose a computational framework that leverages existing out-of-language data to create a conversational agent for the delivery of Self-Attachment Technique (SAT) in Mandarin. Our framework does not require large-scale human translations, yet it achieves a comparable performance whilst also maintaining safety and reliability. We propose two different methods of augmenting available response data through empathetic rewriting. We evaluate our chatbot against a previous, English-only SAT chatbot through non-clinical human trials (N=42), each lasting five days, and quantitatively show that we are able to attain a comparable level of performance to the English SAT chatbot. We provide qualitative analysis on the limitations of our study and suggestions with the aim of guiding future improvements.
Changes in urban and rural education in China under the double reduction policy: parents’ and students' experiences and perspectives
Creators: name: Hu, Zheming
Publisher: name: Stanford Digital Repository
Year: 2023
Subjects: subject: Double Reduction Policy
subject: Chinese education system
subject: Rural-urban divide
subject: Academic anxiety
subject: Parental experience
subject: Education equality
subject: Stanford Graduate School of Education International Education Policy Analysis

description: This study explores students’ and parents’ experiences and perceptions of China’s Double Reduction Policy (DRP), aimed at reducing academic workloads and promote educational equality. Through interviews and qualitative analysis, this study shows the difference between the intended purpose of the policy and actual results, highlighting the urban-oriented nature of its implementation. Although some positive changes have been observed, problems and inequalities remain, especially in rural areas, where access to educational resources and the teaching quality remain under pressure. My findings highlight the need for further research and policy adaptation to ensure that DRP effectively supports all students’ well-being and academic development. In addition, this study offers two policy recommendations: adapt the teacher salary and welfare model to meet the policy goals and implement urban-rural exchange programs to promote rural education. These findings and recommendations contribute to the ongoing debate on education reform in China and emphasize the importance of ensuring equal access to quality education for all students.
The Effect of Agile Software Development on Work Motivation: A Longitudinal Study
Creators: name: Tchikanmou, Vincent Auriol
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Organization Development
subject: Engineering
subject: Computer Engineering
subject: Computational Engineering
subject: Electrical and Computer Engineering
subject: Automotive Engineering
subject: FOS: Mechanical engineering
subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: Since the establishment of the Agile Manifesto in the early 2000s, new software development methodologies have emerged under the heading of 'Agile', differentiating themselves from so-called traditional methods and gaining an unprecedented reputation far beyond the boundaries of software development. Although there are now a number of empirical studies demonstrating the effectiveness of agile software development methods in relation to their goal of "developing better ways to develop software" (Beck et al., 2001), even after two decades the term agile remains an abstract concept whose definition, operationalization and even conclusions about the triggers for its success are disputed among researchers. For the authors of the agile manifesto, the novelty of the agile method lies in the "recognition of people as the primary drivers of project success...". (Highsmith and Cockburn, 2001). In practice, according to some authors, this is reflected in the creation of a work environment in which people are highly motivated (Asproni, 2004). A glance at the literature on the relationship between agility and motivation shows a mixed picture. While Kakar (2017) was able to demonstrate higher motivation among employees in agile projects compared to those in non-agile projects, Arndt (2020) found no difference between the two groups. Memeti et al. (2021), who, unlike Kakar (2017) and Arndt (2020), did not compare groups, could not demonstrate a direct relationship between the use of agile practices and motivation. However, these results contradict the work of Gunawardena (2009), that found a positive correlation. Even though the result of the above mentioned work cannot be compared without reservation as the authors partly use different constructs of motivation and agility in their work and possibly therefore arrive at different results, these give cause for a new investigation of the relationship between agility and motivation.
Amblyaspis walkeri Forster 1861
Creators: name: Awad, Jessica
name: Zimmermann, Dominique
name: Talamas, Elijah
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Platygastridae
Amblyaspis
Amblyaspis walkeri

description: Amblyaspis walkeri Förster, 1861
Amblyaspis walkeri Förster, 1861: 41. Type locality: Switzerland, Val Roseg.
Amblyaspis walkeri – Vlug 1973: 177 (lectotype designation).
Material examined
Lectotype SWITZERLAND • 1♀; Rosegg-Thal [Val Roseg];[July1861];[A.Förster leg.]; NHMW-HYM#0005322.
description: Published as part of Awad, Jessica, Zimmermann, Dominique & Talamas, Elijah, 2024, A photographic type catalogue of Platygastroidea (Insecta, Hymenoptera) in the Natural History Museum Vienna, pp. 1-58 in European Journal of Taxonomy 938 on page 4, DOI: 10.5852/ejt.2024.938.2565, http://zenodo.org/record/12106502
Additional file 6 of Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
Creators: name: Rossi, Alessandro
name: Assunto, Antonia
name: Rosano, Carmen
name: Tucci, Sara
name: Ruoppolo, Margherita
name: Caterino, Marianna
name: Pirozzi, Francesca
name: Strisciuglio, Pietro
name: Parenti, Giancarlo
name: Melis, Daniela
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 6: Supplemental table 1. Clinical information of GSDIa patients.
Coupled carbon and nitrogen losses in response to seven years of chronic warming in subarctic soils
Creators: name: Marañón Jiménez, Sara
name: Penuelas, Josep
name: Richter, Andreas
name: Sigurdsson, Bjarni D.
name: Fuchslueger, Lucia
name: Leblans, Niki I. W.
name: Janssens, Ivan
Publisher: name: Zenodo
Year: 2019

description: Increasing temperatures may alter the stoichiometric demands of soil microbes and impair their capacity to stabilize carbon (C) and retain nitrogen (N), with critical consequences for the soil C and N storage at high latitude soils. Geothermally active areas in Iceland provided wide, continuous and stable gradients of soil temperatures to test this hypothesis. In order to characterize the stoichiometric demands of microbes from these subarctic soils, we incubated soils from ambient temperatures after the factorial addition of C, N and P substrates separately and in combination. In a second experiment, soils that had been exposed to different in situ warming intensities (+0, +0.5, +1.8, +3.4, +8.7, +15.9 °C above ambient) for seven years were incubated after the combined addition of C, N and P to evaluate the capacity of soil microbes to store and immobilize C and N at the different warming scenarios. The seven years of chronic soil warming triggered large and proportional soil C and N losses (4.1 ± 0.5% °C−1 of the stocks in unwarmed soils) from the upper 10 cm of soil, with a predominant depletion of the physically accessible organic substrates that were weakly sorbed in soil minerals up to 8.7 °C warming. Soil microbes met the increasing respiratory demands under conditions of low C accessibility at the expenses of a reduction of the standing biomass in warmer soils. This together with the strict microbial C:N stoichiometric demands also constrained their capacity of N retention, and increased the vulnerability of soil to N losses. Our findings suggest a strong control of microbial physiology and C:N stoichiometric needs on the retention of soil N and on the resilience of soil C stocks from high-latitudes to warming, particularly during periods of vegetation dormancy and low C inputs.