cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metropolitan all-pass and inter-city quantum communication network
Creators: name: Chen, Teng-Yun
name: Wang, Jian
name: Liang, Hao
name: Liu, Wei-Yue
name: Liu, Yang
name: Jiang, Xiao
name: Wang, Yuan
name: Wan, Xu
name: Cai, Wei-Qi
name: Ju, Lei
name: Chen, Luo-Kan
name: Wang, Liu-Jun
name: Gao, Yuan
name: Chen, Kai
name: Peng, Cheng-Zhi
name: Chen, Zeng-Bing
name: Pan, Jian-Wei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We have demonstrated a metropolitan all-pass quantum communication network in field fiber for four nodes. Any two nodes of them can be connected in the network to perform quantum key distribution (QKD). An optical switching module is presented that enables arbitrary 2-connectivity among output ports. Integrated QKD terminals are worked out, which can operate either as a transmitter, a receiver, or even both at the same time. Furthermore, an additional link in another city of 60 km fiber (up to 130 km) is seamless integrated into this network based on a trusted relay architecture. On all the links, we have implemented protocol of decoy state scheme. All of necessary electrical hardware, synchronization, feedback control, network software, execution of QKD protocols are made by tailored designing, which allow a completely automatical and stable running. Our system has been put into operation in Hefei in August 2009, and publicly demonstrated during an evaluation conference on quantum network organized by the Chinese Academy of Sciences on August 29, 2009. Real-time voice telephone with one-time pad encoding between any two of the five nodes (four all-pass nodes plus one additional node through relay) is successfully established in the network within 60km.
description: 9 pages, 2 figures, 2 tables
Design of Low-Thrust Gravity Assist Trajectories to Europa
Creators: name: Vasile, Massimiliano
name: Campagnola, Stefano
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents the design of a mission to Europa using solar electric propulsion as main source of thrust. A direct transcription method based on Finite Elements in Time was used for the design and optimisation of the entire low-thrust gravity assist transfer from the Earth to Europa. Prior to that, a global search algorithm was used to generate a set of suitable first guess solutions for the transfer to Jupiter, and for the capture in the Jovian system. In particular, a fast deterministic search algorithm was developed to find the most promising set of swing-bys to reach Jupiter A second fast search algorithm was developed to find the best sequence of swing-bys of the Jovian moons. After introducing the global search algorithms and the direct transcription through Finite Elements in Time, the paper presents a number of first guess Solutions and a fully optimised transfer from the Earth to Europa.
In silico drug design and molecular docking studies targeting Akt1 (RAC-alpha serine/threonine-protein kinase) and Akt2 (RAC-beta serine/threonine-protein kinase) proteins and investigation of CYP (cytochrome P450) inhibitors against MAOB (monoamine oxidase B) for OSCC (oral squamous cell carcinoma) treatment
Creators: name: Siam, Mohammad Kawsar Sharif
name: Sarker, Anusree
name: Sayeem, Mohammad Manzur Sharif
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: The overexpression of Akt1 (RAC-alpha serine/threonine-protein Kinase) and Akt2 (RAC-beta serine/threonine-protein Kinase) is a hallmark of Oral Squamous Cell Carcinoma (OSCC). Because of the elevated frequency of OSCC occurrence in South Asian countries, novel therapeutic approaches are indispensable. Drugs that inhibit the overexpression of Akt1 and Akt2 proteins in Akt pathway and do not cause reduced expression of MAOB can be leads for OSCC treatment. In this study, Akt1, Akt2 and MAOB were targeted and 100 CYP inhibitors were screened through several in silico approaches and Galuteolin and Linarin were identified as potential leads for OSCC treatment as they inhibited Akt1 proteins with strong binding affinities of −12.3 and −11.5 kcal/mol respectively and also Akt2 proteins with strong binding affinities of −11.4 and −11.1 kcal/mol respectively, but they did not inhibit MAOB. Decreased expression of MAOB in tissues causes OSCC but overexpression is also responsible for other types of diseases and cancers. From the investigation of CYP inhibitors against MAOB, five CYP inhibitors- Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin have expressed inhibitory action against MAOB without any interference with Akt1 and Akt2. This study mainly represents that Galuteolin and Linarin in the Akt pathway can be perceived for OSCC treatment and other five CYP inhibitors – Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin for the treatment of other diseases and cancers caused by overexpression of MAOB. ADMET properties of CYP inhibitors obtained from admetSAR 2.0 and were compared with reference drugs for validation. Communicated by Ramaswamy H. Sarma.
On the CFT duals for near-extremal black holes
Creators: name: Rasmussen, Jorgen
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider Kerr-Newman-AdS-dS black holes near extremality and work out the near-horizon geometry of these near-extremal black holes. We identify the exact U(1)_L x U(1)_R isometries of the near-horizon geometry and provide boundary conditions enhancing them to a pair of commuting Virasoro algebras. The conserved charges of the corresponding asymptotic symmetries are found to be well defined and non-vanishing and to yield central charges c_L\neq0 and c_R=0. The Cardy formula subsequently reproduces the Bekenstein-Hawking entropy of the black hole. This suggests that the near-extremal Kerr-Newman-AdS-dS black hole is holographically dual to a non-chiral two-dimensional conformal field theory.
description: 11 pages
Dynamo action in cellular convection
Creators: name: Seehafer, Norbert
name: Demircan, Ayhan
Publisher: name: Weierstrass Institute
Year: 2003
Subjects: subject: Magnetohydrodynamics
subject: Convection
subject: Dynamo
subject: 76U05
subject: 76W05
subject: 42.65.Tg
subject: 42.81.Dp

description: The dynamo properties of square patterns in Boussinesq Rayleigh-Benard convection in a plane horizontal layer are studied numerically. Cases without rotation and with weak rotation about a vertical axis are considered, particular attention being paid to the relation between dynamo action and the kinetic helicity of the flow. While the fluid layer is symmetric with respect to up-down reflections, the square-pattern solutions may or may not possess this vertical symmetry. Vertically symmetric solutions, appearing in the form of checkerboard patterns, do not possess a net kinetic helicity and we find them to be incapable of dynamo action at least up to magnetic Reynolds numbers of ≈ 12000. Vertically asymmetric squares, a secondary convection pattern appearing via the skewed varicose instability of rolls and being characterized by rising (descending) motion in the centers and descending (rising) motion near the boundaries, can in turn be devided into such that possess full horizontal square symmetry and others lacking also this symmetry. The flows lacking both the vertical and horizontal symmetries are particularly interesting in that they possess kinetic helicity and show kinematic dynamo action even without rotation. The generated magnetic fields are concentrated in vertically oriented filamentary structures near cell boundaries. The dynamos found in the nonrotating case are, however, always only kinematic, never nonlinear dynamos. Nonlinearly the back-reaction of the magnetic field then forces the flow into the basin of attraction of a roll-pattern solution incapable of dynamo action. But with rotation added parameter regions are found where a subtle balance between the Coriolis and Lorentz forces enables nonlinear dynamo action of stationary asymmetric squares. In some parameter regions this balance leads to nonlinear dynamos with flows in the form of oscillating squares or stationary modulated rolls.
Breaking the Legend: Maxmin Fairness notion is no longer effective
Creators: name: Miaji, Yaser
name: Hassan, Suhaidi
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences
subject: G.3
subject: 41-04

description: In this paper we analytically propose an alternative approach to achieve better fairness in scheduling mechanisms which could provide better quality of service particularly for real time application. Our proposal oppose the allocation of the bandwidth which adopted by all previous scheduling mechanism. It rather adopt the opposition approach be proposing the notion of Maxmin-charge which fairly distribute the congestion. Furthermore, analytical proposition of novel mechanism named as Just Queueing is been demonstrated.
description: 8 Pages
Detection of spin injection into a double quantum dot: Violation of magnetic-field-inversion symmetry of nuclear polarization instabilities
Creators: name: Rudner, Mark S.
name: Rashba, Emmanuel I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In mesoscopic systems with spin-orbit coupling, spin-injection into quantum dots at zero magnetic field is expected under a wide range of conditions. However, up to now, a viable approach for experimentally identifying such injection has been lacking. We show that electron spin injection into a spin-blockaded double quantum dot is dramatically manifested in the breaking of magnetic- field-inversion symmetry of nuclear polarization instabilities. Over a wide range of parameters, the asymmetry between positive and negative instability fields is extremely sensitive to the injected electron spin polarization and allows for the detection of even very weak spin injection. This phenomenon may be used to investigate the mechanisms of spin transport, and may hold implications for spin-based information processing.
Designing novel inhibitors against cyclopropane mycolic acid synthase 3 (PcaA): targeting dormant state of Mycobacterium tuberculosis
Creators: name: Verma, Jyoti
name: Subbarao, Naidu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Mycobacterium tuberculosis can sustain inside the host in dormant (non-replicating) state for years. It suppresses the host immune system by residing in the host alveolar macrophage, resulting in the development of latent tuberculosis. Despite many antibiotics available for the treatment of tuberculosis, the major hurdle in complete elimination is the ability of the bacilli to undergo dormancy and develop resistance against the existing drugs. Cyclopropanation of mycolic acids present in the cell wall of mycobacteria is required for its persistence and virulence. Cyclopropane synthases such as PcaA, CmaA1 and CmaA2, introduce site-specific modifications in mycolic acids. PcaA expression levels are high during dormancy and the gene mutants fails to persist, showing reduced survival in host macrophage. Hence, PcaA appears as a potential target to develop inhibitors against the dormant bacilli. In this study, we have identified compounds with maximum binding affinity against PcaA by in-silico virtual screening of anti-tuberculosis compounds and their structural analogues. In-silico docking followed molecular dynamic simulations and free energy calculations of the compounds with highest docking score in their respective libraries. This study reports novel inhibitors that can act as better anti-tuberculosis compounds targeting PcaA. Communicated by Ramaswamy H. Sarma
D10.4 Feasibility study for CAP Process scale-up
Creators: name: Augustsson, Ola
name: Oskarsson, Andreas
name: Grubbström, Jörgen
name: Sutter, Daniel
Publisher: name: Zenodo
Year: 2018
Subjects: Ammonia
CO2 absorption

description: The Chilled Ammonia Process has been developed by General Electric Power for the power plant application up to a level of Technical Readiness Level of 7 (TRL 7) before entering the CEMCAP project. This report explains the efforts made for reaching this level. It also briefly describes efforts in the CEMCAP to reach to a high TRL of 6 for cement application and how this would be implemented in a cement plant. Finally, it also defines the efforts required to reach TRL of 7 and beyond for also cement application.
description: This work was supported by the Swiss State Secretariat for Education, Research and Innovation (SERI)
under contract number 15.0160
Shear-induced aggregation of amyloid β (1–40) in a parallel plate geometry
Creators: name: Sharma, Laipubam Gayatri
name: Pandey, Lalit M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Protein aggregation is induced by various environmental or external factors and associated with various neurodegenerative diseases. Among various external factors, shear stress is inevitable for both in vivo and in vitro applications of proteins. In this study, Aβ (1–40) peptide, a derivative of the amyloid precursor protein, was subjected to constant (300, 500, 700 s−1) and varying (ramp) shear in a parallel plate geometry to explore the implications of shear in terms of macro (viscosity) and micro (secondary structure, morphology) characteristics. Aβ (1–40) solution followed a shear thickening flow behaviour with performance index value ‘n’ of 2.12. The fibrillation process resulting from the shear force was evaluated in terms of dissipation energy, which was found to exceed the free energy of unfolding. This resulted in the formation of β-sheet rich structures, which were confirmed by CD and FTIR analyses and enhanced Th-T fluorescence. The apparent rate of aggregation (k) was found to increase with the shear rate, and inversely related to the solution viscosity. The maximum k value was 0.21 ± 0.3 min−1 at 700 s−1. The molecular weights of aggregates were determined using gel filtration, which were proportionally related to the solution viscosity. The average molecular weights were estimated to be 70, 62 and 52 KDa for samples sheared at 300, 500 and 700 s−1, respectively. The present study has deciphered the interplay of viscosity, a fluid property, with the aggregation process and its corresponding change in the secondary structures of the peptide. These findings provide useful insights for understanding various proteopathies under shear force. Communicated by Ramaswamy H. Sarma
Effect of polydispersity and soft interactions on the nematic vs. smectic phase stability in platelet suspensions
Creators: name: Martinez-Raton, Yuri
name: Velasco, Enrique
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We discuss theoretically, using density-functional theory, the phase stability of nematic and smectic ordering in a suspension of platelets of the same thickness but with a high polydispersity in diameter, and study the influence of polydispersity on this stability. The platelets are assumed to interact like hard objects, but additional soft attractive and repulsive interactions, meant to represent the effect of depletion interactions are also considered. The aspect (diameter to thickness) ratio is taken to be very high, in order to model solutions of mineral platelets recently explored experimentally. In this regime a high degree of orientational ordering occurs; therefore the model platelets can be taken as completely parallel and are amenable to analysis via a fundamental-measure theory. Our focus is on the nematic vs. smectic phase interplay, since a high degree of polydispersity in diameter suppresses the formation of the columnar phase. When interactions are purely hard, the theory predicts a continuous nematic-to-smectic transition, regardless of the degree of diameter polydispersity. However, polydispersity enhances the stability of the smectic phase against the nematic phase. Predictions for the case where an additional soft interaction is added are obtained using mean-field perturbation theory. In the case of the one-component fluid, the transition remains continuous for repulsive forces, and the smectic phase becomes more stable as the range of the interaction is decreased. The opposite behaviour with respect to the range is observed for attractive forces, and in fact the transition becomes of first order below a tricritical point. Also, for attractive interactions, nematic demixing appears, with an associated critical point. When platelet polydispersity is introduced the tricritical temperature shifts to very high values.
description: 12 pages, 11 figures
The spectral action and cosmic topology
Creators: name: Marcolli, Matilde
name: Pierpaoli, Elena
name: Teh, Kevin
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 83C65, 83F05

description: The spectral action functional, considered as a model of gravity coupled to matter, provides, in its non-perturbative form, a slow-roll potential for inflation, whose form and corresponding slow-roll parameters can be sensitive to the underlying cosmic topology. We explicitly compute the non-perturbative spectral action for some of the main candidates for cosmic topologies, namely the quaternionic space, the Poincare' dodecahedral space, and the flat tori. We compute the corresponding slow-roll parameters and see we check that the resulting inflation model behaves in the same way as for a simply-connected spherical topology in the case of the quaternionic space and the Poincare' homology sphere, while it behaves differently in the case of the flat tori. We add an appendix with a discussion of the case of lens spaces.
description: 55 pages, LaTeX
The effect of acute intermittent hypoxia on sympathetic neurovascular transduction
Creators: name: Stuckless, Troy
Publisher: name: University of British Columbia
Year: 2018

description: Obstructive sleep apnea (OSA) patients suffer from intermittent hypoxia (IH) due to repetitive airway obstructions during sleep. IH increases chemoreflex sensitivity, sympathetic vasomotor outflow, and increases blood pressure. The purpose of this study was to determine if acute IH augments sympathetic neurovascular transduction in young healthy men, which could contribute to an increase in blood pressure. It was hypothesized that IH would augment sympathetic neurovascular transduction. Ten healthy males without OSA were exposed to 40 seconds of hypercapnic hypoxia (PETO₂ = 48.1 ± 1 mmHg, PETCO₂: + 4 ± 1 mmHg above baseline) and 20 seconds of normoxia for 40-minutes, mimicking severe OSA. Before and after IH we measured muscle sympathetic nerve activity burst frequency (MSNA BF; peroneal microneurography) and forearm vascular resistance (FVR; brachial artery duplex ultrasound) during rest and three levels of lower body negative pressure (15, 30, and 45 mmHg) while clamping end-tidal gases at baseline values. Sympathetic neurovascular transduction, defined as the slope of the relationship between MSNA BF and FVR, was increased 3-fold immediately following IH (P = 0.015). IH increased minute ventilation (+5 ± 2 l/min, P = 0.025), suggesting long term facilitation of ventilation. Additionally, MSNA BF (+2 ± 1 /min, P = 0.032) and mean arterial pressure (+5 ± 2 mmHg, P = 0.002) were increased following IH. Our results suggest that acute IH increases sympathetic neurovascular transduction and may be an important early mechanism involved in the development of hypertension in OSA.
Umbral Dynamics in the Near Infrared Continuum
Creators: name: Andic, A.
name: Cao, W.
name: Goode, P. R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We detected peaks of oscillatory power at 3 and ~6.5 minutes in the umbra of the central sunspot of the active region NOAA AR 10707 in data obtained in the near infrared (NIR) continuum at 1565.7 nm. The NIR dataset captured umbral dynamics around 50 km below the photospheric level. The umbra does not oscillate as a whole, but rather in distinct parts that are distributed over the umbral surface. The most powerful oscillations, close to a period of ~ 6.5, do not propagate upward. We noted a plethora of large umbral dots that persisted for more than 30 minutes and stayed in the same locations. The peaks of oscillatory power above the detected umbral dots are located at 3 and 5 minutes oscillations, but are very weak in comparison with the oscillations of ~ 6.5 minutes.
description: 16 pages, 8 figures, accepted in ApJ
Contact resistivity and current flow path at metal/graphene contact
Creators: name: Nagashio, K.
name: Nishimura, T.
name: Kita, K.
name: Toriumi, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The contact properties between metal and graphene were examined. The electrical measurement on a multiprobe device with different contact areas revealed that the current flow preferentially entered graphene at the edge of the contact metal. The analysis using the cross-bridge Kelvin structure (CBK) suggested that a transition from the edge conduction to area conduction occurred for a contact length shorter than the transfer length of ~1 micron. The contact resistivity for Ni was measured as ~5*10-6 Ohmcm2 using the CBK. A simple calculation suggests that a contact resistivity less than 10-9 Ohmcm2 is required for miniaturized graphene field effect transistors.
Forming Protostars in Molecular Clouds with Shocked Envelope Expansion and Core Collapse
Creators: name: Lou, Yu-Qing
name: Gao, Yang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Spectral observations of molecular line profiles reveal the so-called `blue profiles' for double-peaked molecular lines with stronger blue and weaker red peaks as notable features for star-forming cloud core collapses under the self-gravity. In contrast, 25-30 per cent of observed molecular spectral line profiles in star-forming clouds or cores also show the so-called double-peaked `red profiles' with red peaks stronger than blue peaks. Gao & Lou (2010) show that these unexplained `red profiles' can be signatures of global dynamics for envelope expansion with core collapse (EECC) within star-forming molecular clouds or cores. We demonstrate here that spatially-resolved `red profiles' of HCO+ (J=1-0) and CS (J=2-1) molecular transitions from the low-mass star-forming cloud core FeSt 1-457 together with its radial profile of column density inferred from dust extinction observations appear to reveal a self-similar hydrodynamic shock phase for global EECC. Observed spectral profiles of C18O (J=1-0) are also fitted by the same EECC model. For further observational tests, the spatially-resolved profiles of molecular transitions HCO+ (J=3-2) and CS (J=3-2) as well as the radial profiles of (sub)millimetre continuum emissions at three wavelengths of 1.2mm, 0.85mm and 0.45mm from FeSt 1-457 are also predicted.
description: 11 pages, 6 figures, accepted for publication in MNRAS
EVALUATING THE IMPACT OF ORGANIC FARMING POLICIES ON AGRICULTURE IN NIGERIA
Creators: name: Adaobi, Chinyere Nwosu
name: Bolaji, Adebayo Olayemi
name: Samuel, Oluwatobi
name: Chukwuemeka, Victor Eze
Publisher: name: AYDEN JOURNAL
Year: 2024
Subjects: Organic Farming, Policy Interventions, Sustainable Agriculture, Certification Costs, Financial Support, Nigeria

description: This comprehensive systematic review delves into the pivotal role of policy frameworks in catalyzing the adoption and expansion of organic farming in Nigeria. Despite the burgeoning global recognition of organic agriculture's benefits for environmental sustainability and food security, Nigeria's adoption rates remain modest due to formidable obstacles such as exorbitant certification costs, restricted market access, and a pervasive lack of awareness and technical expertise among farmers. This study critically examines the efficacy of existing policies, encompassing subsidies, certification schemes, and educational initiatives, and identifies strategic avenues for enhancement. It advocates for streamlined certification processes, the development of robust local and international markets for organic products, substantial investment in education and extension services, and enhanced financial support mechanisms. By addressing these challenges and leveraging identified opportunities, Nigeria can elevate its organic farming sector, paving the way for a sustainable, resilient, and economically viable agricultural future that aligns with global best practices and supports a healthier environment and economy. This review not only underscores the current limitations but also illuminates a path forward for transforming Nigeria's agricultural landscape through comprehensive policy reform and innovation.
Valorisation of stachysetin from cultivated Stachys iva Griseb. as anti-diabetic agent: a multi-spectroscopic and molecular docking approach
Creators: name: Pritsas, Aristeidis
name: Tomou, Ekaterina-Michaela
name: Tsitsigianni, Eleni
name: Papaemmanouil, Christina D.
name: Diamantis, Dimitrios A.
name: Chatzopoulou, Paschalina
name: Tzakos, Andreas G.
name: Skaltsa, Helen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Stachys species are considered as important medicinal plants with numerous health benefit effects. In continuation of our research on the Greek Stachys species, the chemical profile of the aerial parts of cultivated S. iva Griseb. has been explored. The NMR profiles of the plant extract/infusion were used to guide the isolation process, leading to the targeted isolation of seventeen known compounds. The rare acylated flavonoid, stachysetin, was isolated for the third time from plant species in the international literature. Identification of the characteristic signals of stachysetin in the 1D 1H-NMR spectrum of the crude extract was presented. In order to evaluate the potential of the identified chemical space in Stachys to bear possible bioactivity against diabetes, we performed an in silico screening against 17 proteins implicated in diabetes, as also ligand based similarity metrics against established anti-diabetic drugs. The results capitalized the anti-diabetic potency of stachysetin. Its binding profile to the major drug carrier plasma protein serum albumin was also explored along with its photophysical properties suggesting that stachysetin could be recognized and delivered in plasma through serum albumin and also could be tracked through near-infrared imaging. Communicated by Ramaswamy H. Sarma
Der Durchleuchtigst und Durchleuchtigen Hochgebornen Fürsten und Herren, Herren Johans Friderichen, Hertzogen zu Sachssen ... Und Herrn Philipsen, Landgraven zu Hessen ... Bestendige und warhafftige verantwortung, auch im rechten gegründete widerlegung, warumb die vermeinte ursachen derwegen Karl so sich des namens den Fünfften Römischen Keiser nennet , ire Chur und F. G. vor ungehorsame Chur und Fürsten zu verleumen understanden, in facto und in der that nicht war ...
Creators: name: Von Sachsen, Johann Friedrich Kurfürst
Publisher: name: [Strassburg?] : [publisher not identified]
Year: 2014

description: Ornamented initials.
Hadronic and electromagnetic probes of hot and dense matter in a Boltzmann+Hydrodynamics model of relativistic nuclear collisions
Creators: name: Santini, E.
name: Bäuchle, B.
name: Petersen, H.
name: Steinheimer, J.
name: Nahrgang, M.
name: Bleicher, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present recent results on bulk observables and electromagnetic probes obtained using a hybrid approach based on the Ultrarelativistic Quantum Molecular Dynamics transport model with an intermediate hydrodynamic stage for the description of heavy-ion collisions at AGS, SPS and RHIC energies. After briefly reviewing the main results for particle multiplicities, elliptic flow, transverse momentum and rapidity spectra, we focus on photon and dilepton emission from hot and dense hadronic matter.
description: To appear in the proceedings of WISH 2010: International Workshop on Interplay between Soft and Hard interactions in particle production at ultrarelativistic energies, Catania, Italy, 8-10 September 2010
D2.11 CEMCAP Strategic conclusions – progressing CO2 capture from cement towards demonstration
Creators: name: Jordal, Kristin
name: Abanades, Carlos
name: Berstad, David
name: Cinti, Giovanni
name: Gardarsdottir, Stefania
name: Hoenig, Volker
name: Hornberger, Matthias
name: Monteiro, Juliana Garcia
name: Ruppert, Johannes
name: Størset, Sigmund
name: Sutter, Daniel
name: van der Meer, Rob
name: Voldsund, Mari
Publisher: name: Zenodo
Year: 2019
Subjects: CCS
CO2 capture
Cement
Industry
CO2 utilization
CCUS
Techno-economic comparison
Retrofitability
Technology gaps
Innovation

description: The objective of the 42-month Horizon2020 project CEMCAP (Budget ~10 MEUR) has been to prepare the ground for large-scale implementation of CO2 capture in the European cement industry. CEMCAP has tested and analyzed five different CO2 capture technologies for cement production and performed techno-economic and retrofitability analyses. The investigated technologies are ready for or already progressing towards demonstration beyond CEMCAP. CEMCAP has thus created technology pathways for future large-scale CCS implementation in the cement industry, but these pathways need support by an appropriate political framework, business models, a reliable CO2 transport and storage infrastructure and public acceptance for CCS.
description: This work was supported by the Swiss State Secretariat for Education, Research and Innovation (SERI)
under contract number 15.0160
Homology modeling and in silico design of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
Creators: name: Elmezayen, Ammar D.
name: Yelekçi, Kemal
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial effect on various biological systems, mainly by their suppressive effect on transcription. Searching for inhibitors targeting their respective isoforms without affecting other targets is greatly needed. Some histone deacetylases have no crystal structures, such as HDAC5 and HDAC9. Lacking proper and suitable crystal structure is obstructing the designing of appropriate isoform selective inhibitors. Here in this study, we constructed human HDAC5 and HDAC9 protein models using human HDAC4 (PDB:2VQM_A) as a template by the means of homology modeling approach. Based on the Z-score of the built models, model M0014 of HDAC5 and model M0020 of HDAC9 were selected. The models were verified by MODELLER and validated using the Web-based PROCHECK server. All selected known inhibitors displayed reasonable binding modes and equivalent predicted Ki values in comparison to the experimental binding affinities (Ki/IC50). The known inhibitor Rac26 showed the best binding affinity for HDAC5, while TMP269 showed the best binding affinity for HDAC9. The best two compounds, CHEMBL2114980 and CHEMBL217223, had relatively similar inhibition constants against HDAC5 and HDAC9. The built models and their complexes were subjected to molecular dynamic simulations (MD) for 100 ns. Examining the MD simulation results of all studied structures, including the RMSD, RMSF, radius of gyration and potential energy suggested the stability and reliability of the built models. Accordingly, the results obtained in this study could be used for designing de novo inhibitors against HDAC5 and HDAC9. Communicated by Ramaswamy H. Sarma
title: Student Achievement Growth During the COVID-19 Pandemic: Fall 2021 Update - Policy Brief
Creators: name: Sass, Tim
name: Goldring, Thomas
Publisher: name: Georgia Policy Labs
Year: 2021

description: Two years into the COVID-19 pandemic, little information has been available about how students in the metro-Atlanta area are performing academically. Metro districts have adopted different strategies to help students navigate and recover from the pandemic, including small-group tutoring, expanded summer school programs, and additional supports for technology use and student health and wellness. This report continues MAPLE’s research agenda analyzing how the pandemic has affected student achievement in math and reading in metro-Atlanta districts.
Gravitational-wave spin-down and stalling lower limits on the electrical resistivity of the accreted mountain in a millisecond pulsar
Creators: name: Vigelius, Matthias
name: Melatos, Andrew
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The electrical resistivity of the accreted mountain in a millisecond pulsar is limited by the observed spin-down rate of binary radio millisecond pulsars (BRMSPs) and the spins and X-ray fluxes of accreting millisecond pulsars (AMSPs). We find $η\ge 10^{-28}\,\mathrm{s}\, (τ_\mathrm{SD}/1\,\mathrm{Gyr})^{-0.8}$ (where $τ_\mathrm{SD}$ is the spin-down age) for BRMSPs and $η\ge 10^{-25}\,\mathrm{s}\,(\dot{M}_\mathrm{a}/\dot{M}_\mathrm{E})^{0.6}$ (where $\dot{M}_\mathrm{a}$ and $\dot{M}_\mathrm{E}$ are the actual and Eddington accretion rates) for AMSPs. These limits are inferred assuming that the mountain attains a steady state, where matter diffuses resistively across magnetic flux surfaces but is replenished at an equal rate by infalling material. The mountain then relaxes further resistively after accretion ceases. The BRMSP spin-down limit approaches the theoretical electron-impurity resistivity at temperatures $\ga 10^5$ K for an impurity concentration of $\sim 0.1$, while the AMSP stalling limit falls two orders of magnitude below the theoretical electron-phonon resistivity for temperatures above $10^8$ K. Hence BRMSP observations are already challenging theoretical resistivity calculations in a useful way. Next-generation gravitational-wave interferometers will constrain $η$ at a level that will be competitive with electromagnetic observations.
description: accepted for publication in ApJ.
THE CONNECTION BETWEEN LIFESTYLE EDIAND MCINE
Creators: name: Khusainova Mukhiba Shavkatovna Samarkand Abu Ali Ibn Sino Public Health Technical University, teachers of the Department of Community Nursing
name: Khakimova Kh.Kh.  Senior Lecturer at the Department of Public Health and Healthcare Management, SamMU
Publisher: name: Zenodo
Year: 2025

description: This article is devoted to the problems of improving the quality of life and strengthening human health in modern conditions, as well as the influence of physical culture and sports on the formation of a healthy lifestyle (HLS). The importance of physical culture and sports is highlighted as one of the most affordable and effective means that have a beneficial effect on people's health
In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins
Creators: name: Alazmi, Meshari
name: Motwalli, Olaa
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: The ongoing pandemic COVID-19 (COrona Virus Immuno Deficiency-2019) which is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome–CoronaVirus-2) has emerged as a pandemic with 400,000 plus deaths till date. We do not have any drug or vaccine available for the inhibition of this deadly virus. The expedition for searching a potential drug or vaccine against COVID-19 will be of massive potential and favor. This study is focused on finding an effective natural origin compound which can put a check on the activity of this virus. We chose important proteins from the SARS-CoV-2 genome such as NSP4, NSP15 and RdRp along-with the human ACE2 receptor which is the first point of contact with the virus. Virtual screening and followed up molecular docking resulted in Baicalin and Limonin as the final lead molecules. 200 ns of MD simulation for each protein-ligand complex provides the insights that Baicalin has a potential to target NSP4, NSP15 and RdRp proteins. Limonin which is largely used in traditional Indian medicine system is found to inhibit the human ACE2 receptor (making it inefficient in binding to the receptor binding domain of SARS-CoV-2). Our studies propose Baicalin and Limonin in combination to be studied in vitro and in vivo against COVID-19. Communicated by Ramaswamy H. Sarma
Optimizing low-thrust and gravity assist maneuvers to design interplanetary trajectories
Creators: name: Vasile, Massimiliano
name: Bernelli-Zazzera, Franco
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper a direct method based on a transcription by finite elements in time has been used to design optimal interplanetary trajectories, exploiting a combination of gravity assist maneuvers and low-thrust propulsion. A multiphase parametric approach has been used to introduce swing-bys, treated as coast phases between two thrusted or coasting trajectory arcs. Gravity maneuvers are at first modeled with a linked-conic approximation and then introduced through a full three-dimensional propagation including perturbations by the Sun. The method is successfully applied to the design of a mission to planet Mercury, for which different options corresponding to different sequences of gravity maneuvers or launch opportunities are presented.
Designing novel epitope-based polyvalent vaccines against herpes simplex virus-1 and 2 exploiting the immunoinformatics approach
Creators: name: Sarkar, Bishajit
name: Ullah, Md. Asad
name: Araf, Yusha
name: Das, Sowmen
name: Rahman, Md. Hasanur
name: Abu Tayab Moin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Herpes Simplex Virus (HSV) is a highly infectious virus that is responsible for various types of orofacial and genital infections. Two types of HSV exist i.e. HSV-1 and HSV-2, that are infecting millions of people around the world. However, no satisfactory treatment or counter-measure has yet been discovered to fight against the HSV infections. In this study, three possible polyvalent subunit vaccines against multiple strains of HSV-1 and HSV-2, targeting the envelope glycoproteins- E, B, and D, were designed using the tools of reverse vaccinology and immunoinformatics. The highly antigenic, non-allergenic, non-toxic, non-homolog (to the human proteome), and 100% conserved epitopes across the selected strains and species (eight epitopes from each of the CTL, HTL, and BCL epitope groups), were selected for vaccine construction. These designed vaccines are expected to be effective against the selected viral types simultaneously (as a polyvalent vaccine), without producing any unwanted adverse reaction within the body. Finally, from the three vaccine constructs, one best vaccine was determined by molecular docking analysis and thereafter, the MD simulation and immune simulation studies of the best vaccine construct also yielded satisfactory results, pointing towards quite good stability of the complex. Finally, in silico cloning was performed for analyzing the effective mass production strategy of the best vaccine construct. However, wet lab-based study should be conducted on the suggested vaccines for validating their potentiality, safety, and efficacy. Communicated by Ramaswamy H. Sarma
Probing top-gated field effect transistor of reduced graphene oxide monolayer made by dielectrophoresis
Creators: name: Vasu, K. S.
name: Chakraborty, Biswanath
name: Sampath, S.
name: Sood, A. K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate top-gated field effect transistor made of reduced graphene oxide (RGO) monolayer (graphene) by dielectrophoresis. Raman spectrum of RGO flakes of typical size of 5μm x 5μm show a single 2D band at 2687 cm-1, characteristic of a single layer graphene. The two probe current - voltage measurements of RGO flakes, deposited in between the patterned electrodes with a gap of 2.5 μm using a.c. dielectrophoresis show ohmic behavior with a resistance of ~ 37kΩ. The temperature dependence of the resistance (R) of RGO measured between temperatures 305 K to 393 K yields temperature coefficient of resistance [dR/dT]/R ~ -9.5x10-4 K-1, same as mechanically exfoliated single layer graphene. The field effect transistor action was obtained by electrochemical top-gating using solid polymer electrolyte (PEO + LiClO4) and Pt wire. Ambipolar nature of graphene flakes is observed upto a doping level of ~ 6x1012/cm2 and carrier mobility of ~ 50 cm2V-1sec-1. The source - drain current characteristics shows a tendency of current saturation at high source - drain voltage which is analyzed quantitatively by a diffusive transport model.
description: 12 pages, 5 figures
Gauge Field Theory Of Horizontal Su(2) X U(1) Symmetry - Doublet Plus Singlet Scheme
Creators: name: Sogami, Ikuo S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Gauge field theory of a horizontal symmetry of the group G = SU(2) X U(1) is developed so as to generalize the standard model of particle physics. All fermion and scalar fields are assumed to belong to doublets and singlets of the group in high energy regime. Mass matrices with four texture zeros of Dirac and Majorana types are systematically derived. In addition to seven scalar particles, the theory predicts existence of one peculiar vector particle which seems to play important roles in astrophysics and particle physics.
description: 11 pages, no figure
Summa Contra Gentiles: Book One, God
Creators: name: Aquinas, Thomas
Publisher: name: University of Notre Dame
Year: 2023

description: The _Summa Contra Gentiles_ is not merely the only complete summary of Christian doctrine that St. Thomas has written, but also a creative and even revolutionary work of Christian apologetics composed at the precise moment when Christian thought needed to be intellectually creative in order to master and assimilate the intelligence and wisdom of the Greeks and the Arabs. In the _Summa_ Aquinas works to save and purify the thought of the Greeks and the Arabs in the higher light of Christian Revelation, confident that all that had been rational in the ancient philosophers and their followers would become more rational within Christianity.\u000a\u000aThis exposition and defense of divine truth has two main parts: the consideration of that truth that faith professes and reason investigates, and the consideration of the truth that faith professes and reason is not competent to investigate. The exposition of truths accessible to natural reason occupies Aquinas in the first three books of the _Summa_. His method is to bring forward demonstrative and probable arguments, some of which are drawn from the philosophers, to convince the skeptic. In the fourth book of the _Summa_ St. Thomas appeals to the authority of the Sacred Scripture for those divine truths that surpass the capacity of reason.\u000a\u000aThe present volume studies God's existence, nature, and substance, and especially his perfect actuality, the autonomy of his knowledge, the independence of his will, the perfection of his life, and the generosity of his love. Book 2 of the _Summa_ deals with Creation; Book 3, Providence; and Book 4, Salvation.\u000a\u000a\u00A9 University of Notre Dame\u000a\u000aCopyright for most content is held by The University of Notre Dame. Reproduction of all or any portion of content constitutes a violation of copyright. You must obtain permission from The Copyright Clearance Center or The University of Notre Dame Press in order to reprint (or adapt) content.\u000a\u000ap: (574) 631-6346 \ e: undpress@nd\.edu \ website: copyright\.com