cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New insights into intrinsic foot muscle morphology and composition using ultra‐high‐field (7-Tesla) magnetic resonance imaging
Creators: name: Smith, MM Franettovich
name: Elliott, JM
name: Al-Najjar, A
name: Weber, KA
name: Hoggarth, MA
name: Vicenzino, B
name: Hodges, PW
name: Collins, Natalie
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Background: The intrinsic muscles of the foot are key contributors to foot function and are important to evaluate in lower limb disorders. Magnetic resonance imaging (MRI), provides a non-invasive option to measure muscle morphology and composition, which are primary determinants of muscle function. Ultra-high-field (7-T) magnetic resonance imaging provides sufficient signal to evaluate the morphology of the intrinsic foot muscles, and, when combined with chemical-shift sequences, measures of muscle composition can be obtained. Here we aim to provide a proof-of-concept method for measuring intrinsic foot muscle morphology and composition with high-field MRI. Methods: One healthy female (age 39 years, mass 65 kg, height 1.73 m) underwent MRI. A T1-weighted VIBE – radio-frequency spoiled 3D steady state GRE – sequence of the whole foot was acquired on a Siemens 7T MAGNETOM scanner, as well as a 3T MAGNETOM Prisma scanner for comparison. A high-resolution fat/water separation image was also acquired using a 3D 2-point DIXON sequence at 7T. Coronal plane images from 3T and 7T scanners were compared. Using 3D Slicer software, regions of interest were manually contoured for each muscle on 7T images. Muscle volumes and percentage of muscle fat infiltration were calculated (muscle fat infiltration % = Fat/(Fat + Water) x100) for each muscle. Results: Compared to the 3T images, the 7T images provided superior resolution, particularly at the forefoot, to facilitate segmentation of individual muscles. Muscle volumes ranged from 1.5 cm3 and 19.8 cm3, and percentage muscle fat infiltration ranged from 9.2–15.0%. Conclusions: This proof-of-concept study demonstrates a feasible method of quantifying muscle morphology and composition for individual intrinsic foot muscles using advanced high-field MRI techniques. This method can be used in future studies to better understand intrinsic foot muscle morphology and composition in healthy individuals, as well as those with lower disorders.
Supplemental Material, ACM-20-0101-14th_Aug_20_Reply_to_Reviewer_Comments - Significance of tungsten disulfide on the mechanical and machining characteristics of phosphor bronze metal matrix composite
Creators: name: P Sangaravadivel
name: G Rajamurugan
name: Prabu Krishnasamy
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material, ACM-20-0101-14th_Aug_20_Reply_to_Reviewer_Comments for Significance of tungsten disulfide on the mechanical and machining characteristics of phosphor bronze metal matrix composite by P Sangaravadivel, G Rajamurugan and Prabu Krishnasamy in Advanced Composites Letters
New insights into intrinsic foot muscle morphology and composition using ultra‐high‐field (7-Tesla) magnetic resonance imaging
Creators: name: Smith, MM Franettovich
name: Elliott, JM
name: Al-Najjar, A
name: Weber, KA
name: Hoggarth, MA
name: Vicenzino, B
name: Hodges, PW
name: Collins, NJ
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: The intrinsic muscles of the foot are key contributors to foot function and are important to evaluate in lower limb disorders. Magnetic resonance imaging (MRI), provides a non-invasive option to measure muscle morphology and composition, which are primary determinants of muscle function. Ultra-high-field (7-T) magnetic resonance imaging provides sufficient signal to evaluate the morphology of the intrinsic foot muscles, and, when combined with chemical-shift sequences, measures of muscle composition can be obtained. Here we aim to provide a proof-of-concept method for measuring intrinsic foot muscle morphology and composition with high-field MRI. Methods: One healthy female (age 39 years, mass 65 kg, height 1.73 m) underwent MRI. A T1-weighted VIBE – radio-frequency spoiled 3D steady state GRE – sequence of the whole foot was acquired on a Siemens 7T MAGNETOM scanner, as well as a 3T MAGNETOM Prisma scanner for comparison. A high-resolution fat/water separation image was also acquired using a 3D 2-point DIXON sequence at 7T. Coronal plane images from 3T and 7T scanners were compared. Using 3D Slicer software, regions of interest were manually contoured for each muscle on 7T images. Muscle volumes and percentage of muscle fat infiltration were calculated (muscle fat infiltration % = Fat/(Fat + Water) x100) for each muscle. Results: Compared to the 3T images, the 7T images provided superior resolution, particularly at the forefoot, to facilitate segmentation of individual muscles. Muscle volumes ranged from 1.5 cm3 and 19.8 cm3, and percentage muscle fat infiltration ranged from 9.2–15.0%. Conclusions: This proof-of-concept study demonstrates a feasible method of quantifying muscle morphology and composition for individual intrinsic foot muscles using advanced high-field MRI techniques. This method can be used in future studies to better understand intrinsic foot muscle morphology and composition in healthy individuals, as well as those with lower disorders.
Additional file 1 of Autism-associated gene shank3 is necessary for social contagion in zebrafish
Creators: name: Kareklas, Kyriacos
name: Teles, Magda C.
name: Dreosti, Elena
name: Oliveira, Rui F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Figures showing sex comparisons in attention and recognition measures for both wild-types and mutants.
Emergence of a Novel Pathogenic Poxvirus Infection in the Endangered Green Sea Turtle (Chelonia mydas) Highlights a Key Threatening Process
Creators: name: Sarker, Subir
name: H Bielefeldt-Ohmann
name: Athukorala Vidanalage Ajani Priyadarshan Athukorala
name: C Hannon
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Emerging viral disease is a significant concern, with potential consequences for human, animal and environmental health. Over the past several decades, multiple novel viruses have been found in wildlife species, including reptiles, and often pose a major threat to vulnerable species. However, whilst a large number of viruses have been described in turtles, information on poxvirus in cheloniids remains scarce, with no molecular sequence data available to date. This study characterizes, for the first time, a novel poxvirus, here tentatively designated cheloniid poxvirus 1 (ChePV-1). The affected cutaneous tissue, recovered from a green sea turtle (Chelonia mydas) captured off the Central Queensland coast of Australia, underwent histological examination, transmission electron microscopy (TEM), DNA extraction and genomic sequencing. The novel ChePV-1 was shown to be significantly divergent from other known poxviruses and showed the highest sequence similarity (89.3%) to avipoxviruses (shearwater poxvirus 2 (SWPV2)). This suggests the novel ChePV-1 may have originated from a common ancestor that diverged from an avipoxvirus-like progenitor. The genome contained three predicted unique genes and a further 15 genes being truncated/fragmented compared to SWPV2. This is the first comprehensive study that demonstrates evidence of poxvirus infection in a marine turtle species, as well as a rare example of an avipoxvirus crossing the avian-host barrier. This finding warrants further investigations into poxvirus infections between species in close physical proximity, as well as in vitro and in vivo studies of pathogenesis and disease.
A new phenylspirodrimane derivative from the deep-sea-derived fungus Stachybotrys chartarum FS705
Creators: name: Wang, Shuo
name: Li, Saini
name: Chen, Yuchan
name: Wang, Yanlin
name: Liu, Zhaoming
name: Zhang, Weimin
name: Deng, Hong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: A new phenylspirodrimane derivative named stachybotrysin A (1), together with four known analogues (2–5) were isolated and purified from the solid culture of the deep-sea-derived Stachybotrys chartarum FS705. Their structures were determined by comprehensive spectroscopic analysis and the absolute configuration was evaluated by theoretical ECD calculations. Compounds 1–5 were evaluated for their cytotoxic, antibacterial and α-glucosidase inhibitory activities. The results showed that compound 2 displayed mild cytotoxicity with IC50 values in the range of 8.88 ∼ 22.73 µM against four human tumour cell lines, SF-268, MCF-7, HepG-2, and A549. Compound 1 showed strong α-glucosidase inhibitory activity with an IC50 value of 20.68 µM. Compounds 4 and 5 exhibited weak antibacterial activity against Bacillus subtilis.
Telehealth sounds a bit challenging, but it has potential: participant and physiotherapist experiences of gym-based exercise intervention for Achilles tendinopathy monitored via telehealth
Creators: name: F Hasani
name: P Malliaras
name: T Haines
name: Munteanu, Shannon
name: J White
name: J Ridgway
name: P Nicklen
name: A Moran
name: P Jansons
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). Background: Although telehealth is becoming more popular for delivery of care for individuals with musculoskeletal pain, to our knowledge telehealth has not been used to manage Achilles tendinopathy. This research aimed to explore the experience of participants and physiotherapists with gym-based exercise interventions for Achilles tendinopathy monitored via videoconference. Methods: A qualitative, interpretive description design was performed using semi-structured interviews (8 participants) and a focus group (7 physiotherapists). Participants and physiotherapists were interviewed about their experiences of the use of telehealth during a gym-based exercise intervention incorporating different calf load parameters for Achilles tendinopathy. We employed an inductive thematic analysis approach to analyse the data. Results: Three themes identified from both participants and physiotherapists included i) acceptability of telehealth; ii) enablers to adherence with telehealth; and iii) barriers to adherence with telehealth. Two extra themes arose from participants regarding adherence with gym-based exercise, including enablers to adherence with the exercise intervention, and barriers to adherence with the exercise intervention. Both participants and physiotherapists expressed overall satisfaction and acceptability of telehealth monitoring of gym-based exercise. Conclusion: Gym-based exercise intervention for Achilles tendinopathy involving weekly telehealth monitoring was acceptable to both participants and physiotherapists. Potential enablers and barriers were identified that may improve adherence to this type of intervention.
Effect of a culturally safe student placement on students’ understanding of, and confidence with, providing culturally safe podiatry care
Creators: name: M West
name: S Sadler
name: F Hawke
name: Munteanu, Shannon
name: V Chuter
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). Background: For university-based podiatry education there are little data available documenting the delivery method and impact of Aboriginal and Torres Strait Islander health curricula or the use of, and outcomes from, immersive clinical placements generally or specific to podiatry practice. Therefore, the primary aim of this study was to evaluate the effect of undertaking clinical placement in a culturally safe podiatry service for Aboriginal and Torres Strait Islander Peoples on podiatry students’ understanding of, and confidence with, providing culturally safe podiatry care. Methods: Final year University of Newcastle undergraduate podiatry students attending a culturally safe Aboriginal and Torres Strait Islander student clinic at a local hospital were purposively recruited to participate. Students completed a custom-made and pilot-tested cultural awareness and capability survey before and after placement. Survey domains were determined from a principle component analysis. The Wilcoxon Signed Rank test was used to compare pre-placement scores on each domain of the survey to the post-placements scores. Effect sizes were calculated and interpreted as small (0.1–0.29), medium (0.3–0.49), and large (≥0.5). Results: This study recruited 58 final year University of Newcastle podiatry students to complete baseline and follow-up surveys. For survey domain 1 (level of understanding of power relationships), domain 2 (level of understanding of the interrelationship between culture and self-perceived health), domain 3 (level of understanding of the importance of culture in clinical practice and access to health care), and domain 4 (level of confidence with providing culturally safe care) a statistically significant (p < 0.05) increase in scores was recorded post-placement. The effect sizes were medium to large. Conclusion: This study demonstrated that an immersive student placement at a culturally safe podiatry clinic significantly improved students’ understanding of, and confidence with, providing culturally appropriate care to Aboriginal and Torres Strait Islander Peoples. This study provides foundation evidence of the role that such placements have on developing students’ cultural capability in a tertiary health care setting, and will help inform future curricula development at both educational institutions and health services, as well as form the basis for ongoing research.
The_Stratification_of_Media_Usage_in_Finland_APPENDIX – Supplemental material for The stratification of media usage in Finland, 2007–2018: Signs of socio-political polarization?
Creators: name: Riie Heikkilä
name: Leguina, Adrian
name: Semi Purhonen
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, The_Stratification_of_Media_Usage_in_Finland_APPENDIX for The stratification of media usage in Finland, 2007–2018: Signs of socio-political polarization? by Riie Heikkilä, Adrian Leguina and Semi Purhonen in New Media & Society
Quantifying the Burden of Shoulder and Hip Pain In Water Polo Players Across Different Playing Levels
Creators: name: Girdwood, Michael
name: Webster, Marilyn
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: BackgroundWater polo is characterised by unique skills and movements with high demands of both the upper and lower limb. There is growing recognition of the problems of shoulder and hip/groin symptoms in this population.PurposeTo quantify the prevalence of shoulder and hip/groin pain in water polo players, and to describe how performance and participation were impacted. Secondary aims investigated whether demographic or training variables were associated with levels of symptoms.DesignIn-season, cross-sectional questionnaire study.MethodsAn online questionnaire was distributed to all adult levels of the Australian water polo community. Participants were asked about demographic and playing history, and then specific injury history at both the shoulder and hip/groin. Each respondent completed an Oslo Sports Trauma Research Centre (OSTRC) overuse injury questionnaire for the shoulder and hip/groin. Point prevalence and past history were calculated, as well as a morbidity score from OSTRC responses. Risk ratios were used to determine differences between playing levels and sex.ResultsOne hundred, fifty-three respondents completed the questionnaire (57% female). High rates of shoulder pain were reported (38.1% current, 81.2% past history), as well as hip/groin pain (33.1% current, 60.4% past history). Current shoulder pain was a risk factor for hip/groin pain (RR 1.99 (95%CI 1.27-3.12), and hip/groin pain was a risk factor for shoulder pain (RR 1.70 (95%CI 1.23-2.35). Elite-level athletes had higher prevalence (RR 1.87 [95%CI 1.01-3.46]) and past history of hip/groin pain (RR 1.76 [95%CI 1.32-2.36]).ConclusionsThis is the first study to quantify high self-reported levels of hip/groin pain in water polo athletes. Such high levels may be explained by high amounts of eggbeater kick, especially during skeletal development in adolescence. Shoulder pain continues to be the most common source of injury burden in water polo. Future research should determine whether any modifiable risk factors exist that may reduce the burden of injury in this population.Level of evidence2b.
A novel method for detecting conformation-dependent β-glucans—single, double, and triple-helical from Shiitake mushroom
Creators: name: Chakraborty, Shuvarghya
name: Beura, Muskan
name: Devi, Konjengbam Sarda
name: Singh, Akoijam Ratankumar
name: Keerthana, CS
name: Sharma, Susheel Kumar
name: Singh, Archana
name: Dahuja, Anil
name: Krishnan, Veda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: This pioneering study explores the structural intricacies of therapeutic β-glucan in Shiitake (Lentinula edodes), i.e. Lentinan (LNT). Lentinan, a neutral polysaccharide [β-(1,3; 1,6) glucan], exists in three forms; single, double, and triple-helical, but conformation-dependent bioactivity studies are lacking. In this context, we meticulously assessed indigenous Shiitake accessions from Northeast India, unveiling the conformational spectrum of LNT through an innovative pipeline. The experiment approached the simultaneous estimation of total glucan (TG), triple helical glucan (THG), and single-double helical glucan (SDG). Profiling revealed the exceptional LNT content in DMRO-623 (TG: 46.74%, SDG: 9.34%, THG: 37.39%) which emerged as the highest documented to date. Beyond the culinary delight, this research and the novel approach to LNT quantification will create a pivotal platform for advanced mushroom research, offering prospects for novel discoveries, innovative applications, and therapeutic potential.
Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies
Creators: name: Harindra Jayasekara
name: RJ MacInnis
name: L Lujan-Barroso
name: AL Mayen-Chacon
name: AJ Cross
name: B Wallner
name: D Palli
name: F Ricceri
name: V Pala
name: S Panico
name: R Tumino
name: T Kühn
name: R Kaaks
name: K Tsilidis
name: MJ Sánchez
name: P Amiano
name: E Ardanaz
name: MD Chirlaque López
name: S Merino
name: JA Rothwell
name: MC Boutron-Ruault
name: G Severi
name: H Sternby
name: E Sonestedt
name: B Bueno-De-Mesquita
name: H Boeing
name: R Travis
name: TM Sandanger
name: A Trichopoulou
name: A Karakatsani
name: E Peppa
name: A Tjønneland
name: Y Yang
name: AM Hodge
name: H Mitchell
name: A Haydon
name: Room, Robin
name: JL Hopper
name: E Weiderpass
name: MJ Gunter
name: E Riboli
name: GG Giles
name: RL Milne
name: A Agudo
name: DR English
name: P Ferrari
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (P =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences. homogeneity
Building an Indigenous-led evidence base for smoking cessation care among Aboriginal and Torres Strait Islander women during pregnancy and beyond: Research protocol for the which way? project
Creators: name: M Bovill
name: Chamberlain, Catherine
name: J Bennett
name: H Longbottom
name: S Bacon
name: B Field
name: P Hussein
name: R Berwick
name: G Gould
name: P O’mara
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Strong and healthy futures for Aboriginal and Torres Strait Islander people requires engagement in meaningful decision making which is supported by evidence-based approaches. While a significant number of research publications state the research is co-designed, few describe the research process in relation to Indigenous ethical values. Improving the health and wellbeing of Aboriginal and Torres Strait Islander mothers and babies is crucial to the continuation of the oldest living culture in the world. Developing meaningful supports to empower Aboriginal and Torres Strait Islander mothers to quit smoking during pregnancy is paramount to addressing a range of health and wellbeing outcomes. Aboriginal and Torres Strait Islander women have called for non-pharmacological approaches to smoking cessation during pregnancy. We describe a culturally responsive research protocol that has been co-designed and is co-owned with urban and regional Aboriginal communities in New South Wales. The project has been developed in line with the AH&MRC’s (Aboriginal Health & Medical Research Council) updated guidelines for ethical research with Aboriginal and Torres Strait Islander communities. Ethics approvals have been granted by AH&MRC #14541662 University of Newcastle HREC H-2020-0092 and the Local Health District ethics committee 2020/ETH02095. Results will be disseminated through peer reviewed articles, community reports, infographics, and online social media content.
Physicochemical analysis of sealants from Anatomic collection in fluid of the MNHN: evolution of historical recipes.
Creators: name: Zuber, Baptiste
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Physicochemical analysis of sealants from Anatomic collection in fluid of the MNHN: evolution of historical recipes. by Phd Student Baptiste Zuber of Phd Student Muséum National d'Histoire Naturelle - CNRS Paris France for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Evaluation of chemical compositions and biological activities of Dendrobium species
Creators: name: Rachkeeree, Apinya
name: Suksathan, Ratchuporn
name: Puangpradab, Ratchadawan
name: Pingyot, Thitiporn
name: Pawin, Benjaporn
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Dendrobium spp. were investigated for their chemical compositions with HPTLC/CMS, and biological properties, including antioxidant activities (DPPH and ABTS.+ assay), and anti-acetylcholinesterase (AChE). The ethanolic extracts of Dendrobium orchid pseudobulbs (D. chrysotoxum; DC, D. fimbriatum; DF, D. lindleyi; DL, and D. pulchellum; DP) were found to contain caffeic acid, gallic acid, quercetin, rutin hydrate and vanillin. While luteolin was shown in D. fimbriatum and D. lindleyi extracts. D. lindleyi, and D. pulchellum extracts presented the high value of total phenolic and flavonoid contents, resulting in a strong antioxidant property. Moreover, D. chrysotoxum extract expressed AChE inhibitory potential. This research indicated that chemical compounds in Dendrobium would be involved with their biological properties, i.e. antioxidant and anti-AChE. This information can be used to support further in-depth research and product development in health, food, and pharmaceutical.
A Transcription Regulatory Sequence in the 5' Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs
Creators: name: Dehcheshmeh, Manijeh Mohammadi
name: SM Moghbeli
name: S Rahimirad
name: IO Alanazi
name: ZSA Shehri
name: Esmaeil Ebrahimie
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Our knowledge of the evolution and the role of untranslated region (UTR) in SARS-CoV-2 pathogenicity is very limited. Leader sequence, originated from UTR, is found at the 5' ends of all encoded SARS-CoV-2 transcripts, highlighting its importance. Here, evolution of leader sequence was compared between human pathogenic and non-pathogenic coronaviruses. Then, profiling of microRNAs that can inactivate the key UTR regions of coronaviruses was carried out. A distinguished pattern of evolution in leader sequence of SARS-CoV-2 was found. Mining all available microRNA families against leader sequences of coronaviruses resulted in discovery of 39 microRNAs with a stable thermodynamic binding energy. Notably, SARS-CoV-2 had a lower binding stability against microRNAs. hsa-MIR-5004-3p was the only human microRNA able to target the leader sequence of SARS and to a lesser extent, also SARS-CoV-2. However, its binding stability decreased remarkably in SARS-COV-2. We found some plant microRNAs with low and stable binding energy against SARS-COV-2. Meta-analysis documented a significant (p < 0.01) decline in the expression of MIR-5004-3p after SARS-COV-2 infection in trachea, lung biopsy, and bronchial organoids as well as lung-derived Calu-3 and A549 cells. The paucity of the innate human inhibitory microRNAs to bind to leader sequence of SARS-CoV-2 can contribute to its high replication in infected human cells.
Undertaking a scoping review: A practical guide for nursing and midwifery students, clinicians, researchers, and academics
Creators: name: D Pollock
name: EL Davies
name: MDJ Peters
name: AC Tricco
name: L Alexander
name: P McInerney
name: CM Godfrey
name: Khalil, Hanan
name: Z Munn
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 The Authors. Journal of Advanced Nursing published by John Wiley Wiley & Sons Ltd Aim: The aim of this study is to discuss the available methodological resources and best-practice guidelines for the development and completion of scoping reviews relevant to nursing and midwifery policy, practice, and research. Design: Discussion Paper. Data Sources: Scoping reviews that exemplify best practice are explored with reference to the recently updated JBI scoping review guide (2020) and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review extension (PRISMA-ScR). Implications for nursing and midwifery: Scoping reviews are an increasingly common form of evidence synthesis. They are used to address broad research questions and to map evidence from a variety of sources. Scoping reviews are a useful form of evidence synthesis for those in nursing and midwifery and present opportunities for researchers to review a broad array of evidence and resources. However, scoping reviews still need to be conducted with rigour and transparency. Conclusion: This study provides guidance and advice for researchers and clinicians who are preparing to undertake an evidence synthesis and are considering a scoping review methodology in the field of nursing and midwifery. Impact: With the increasing popularity of scoping reviews, criticism of the rigour, transparency, and appropriateness of the methodology have been raised across multiple academic and clinical disciplines, including nursing and midwifery. This discussion paper provides a unique contribution by discussing each component of a scoping review, including: developing research questions and objectives; protocol development; developing eligibility criteria and the planned search approach; searching and selecting the evidence; extracting and analysing evidence; presenting results; and summarizing the evidence specifically for the fields of nursing and midwifery. Considerations for when to select this methodology and how to prepare a review for publication are also discussed. This approach is applied to the disciplines of nursing and midwifery to assist nursing and/or midwifery students, clinicians, researchers, and academics.
A multiregional assessment of transnational pathways of introduction
Creators: name: CM McGrannachan
name: S Pagad
name: McGeoch, Melodie
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021. Christopher McGrannachan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Information on the pathways by which alien taxa are introduced to new regions is vital for prioritising policy and management responses to invasions. However, available datasets are often compiled using disparate methods, making comparison and collation of pathway data difficult. Using a standardised framework for recording and categorising pathway data can help to rectify this problem and provide the information necessary to develop indicators for reporting on alien introductions. We combine the Convention on Biological Diversity’s Pathways Categorisation Scheme (CPC) with data compiled by the Invasive Species Specialist Group (ISSG) to report on multiregional trends on alien introduction pathways over the past 200+ years. We found a significant increase in the documented number of multiregional alien introduction events across all pathways of the CPC’s three hierarchical levels. The ‘escape’ pathway is the most common documented pathway used by alien taxa. Transport stowaways via shipping-related pathways are a rapidly increasing contribution to alien introductions. Most alien introduction events were of unknown pathway origin, highlighting the challenge of information gaps in pathway data and reiterating the need for standardised information-gathering practices. Combining the CPC framework with alien introduction pathways data will standardise pathway information and facilitate the development of global indicators of trends in alien introductions and the pathways they use. These indicators have the potential to inform policy and management strategies for preventing future biological invasions and can be down-scaled to national and regional levels that are applicable across taxa and ecosystems.
Additional file 2 of Oral cancer knowledge, attitudes, and practices among senior dental students in Yemen: a multi-institution study
Creators: name: Shamala, Anas
name: Halboub, Esam
name: Al-Maweri, Sadeq Ali
name: Al-Sharani, Hesham
name: Al-Hadi, Mona
name: Ali, Raheq
name: Laradhi, Hajer
name: Murshed, Heba
name: Mohammed, Marwan Mansoor
name: Ali, Kamran
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Exploratory Factor Analysis of the Indonesian Version of the Clinical Learning Environment, Supervision, and Nurse Teacher Scale (CLES + T)
Creators: name: Sommers, CL
name: Mambu, IR
name: McKenna, Lisa
name: Reisenhofer, Sonia
name: McCaughan, J
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background and Purpose: The purpose of this article is to describe an evaluation of psychometric properties of the Indonesian version of the Clinical Learning Environment, Supervision, and Nurse Teacher (CLES + T) scale, a scale that measures nursing students' perceptions of their clinical learning environment. Methods: The CLES + T was completed by 292 nursing students. Inter-item correlations, exploratory factor analysis, Cronbach's alpha, and evidence of validity were used to examine reliability and validity. Results: Four factors were extracted that explained 58% of the variance. Cronbach alphas ranged from.86–.95. Wording to describe different titles of supervisors was unclear to some of the participants. Conclusion: The Indonesian version of the CLES + T is a reliable version. More research is needed to clarify some of the wording.
Stat3 signalling via the il-6ST/GP130 cytokine receptor promotes epithelial integrity and intestinal barrier function during DSS-induced colitis
Creators: name: L Pang
name: J Huynh
name: Alorro, Mariah Grace
name: Li, Xia
name: Ernst, Matthias
name: Ashwini Chand
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. The intestinal epithelium provides a barrier against commensal and pathogenic microorganisms. Barrier dysfunction promotes chronic inflammation, which can drive the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC). Although the Signal Transducer and Activator of Transcription-3 (STAT3) is overexpressed in both intestinal epithelial cells and immune cells in IBD patients, the role of the interleukin (IL)-6 family of cytokines through the shared IL- 6ST/gp130 receptor and its associated STAT3 signalling in intestinal barrier integrity is unclear. We therefore investigated the role of STAT3 in retaining epithelial barrier integrity using dextran sulfate sodium (DSS)-induced colitis in two genetically modified mouse models, to either reduce STAT1/3 activation in response to IL-6 family cytokines with a truncated gp130ΔSTAT allele (GP130ΔSTAT/+), or by inducing short hairpin-mediated knockdown of Stat3 (shStat3). Here, we show that mice with reduced STAT3 activity are highly susceptible to DSS-induced colitis. Mechanistically, the IL- 6/gp130/STAT3 signalling cascade orchestrates intestinal barrier function by modulating cytokine secretion and promoting epithelial integrity to maintain a defence against bacteria. Our study also identifies a crucial role of STAT3 in controlling intestinal permeability through tight junction proteins. Thus, therapeutically targeting the IL-6/gp130/STAT3 signalling axis to promote barrier function may serve as a treatment strategy for IBD patients.
Case Report: Posterior Reversible Leukoencephalopathy Syndrome (PRES) as a Biologically Predictable Neurological Association in Severe COVID-19. First Reported Case From Australia and Review of Internationally Published Cases
Creators: name: Kulasekara Wijeratne
name: C Wijeratne
name: Karimi, Leila
name: C Sales
name: Crewther, Sheila
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2021 Wijeratne, Wijeratne, Karimi, Sales and Crewther. Reports of different types of neurological manifestations of COVID-19 are rapidly increasing, including changes of posterior reversible leukoencephalopathy syndrome (PRES). Here we describe the first reported case of COVID-19 and PRES in Australia diagnosed on basis of MRI brain imaging and confirmed clinically by presence of confusion, delirium, headaches, also associated with hypertension and blood pressure variability and stable long-term kidney problems. He made full recovery as his blood pressure was controlled and clinical status was supported with appropriate supportive therapy. Although traditionally a rare condition, PRES is likely to be more common among patients with COVID-19 pathobiology there is Renin downregulation of ACE2 receptors, involvement of Renin-Angiotensin-Aldosterone system, endotheliitis, cytokine storm, and hyper-immune response. Thus we advocate clinical suspicion and early brain imaging with MRI brain among vulnerable patients with known co-morbidities, and diagnosed with COVID-19 given that hypertension and blood pressure variability are often exacerbated by acute SARS-CoV-2 immune reactions. Such acute hypertensive encephalopathy was able to be reversed with timely supportive therapy ensuring re-hydration and re-establishment of blood pressure control.
Additional file 1 of Oral cancer knowledge, attitudes, and practices among senior dental students in Yemen: a multi-institution study
Creators: name: Shamala, Anas
name: Halboub, Esam
name: Al-Maweri, Sadeq Ali
name: Al-Sharani, Hesham
name: Al-Hadi, Mona
name: Ali, Raheq
name: Laradhi, Hajer
name: Murshed, Heba
name: Mohammed, Marwan Mansoor
name: Ali, Kamran
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Supplementary_File_Appendix – Supplemental material for Explaining Variability in Response Style Traits: A Covariate-Adjusted IRTree
Creators: name: Ames, Allison J.
name: Myers, Aaron J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary_File_Appendix for Explaining Variability in Response Style Traits: A Covariate-Adjusted IRTree by Allison J. Ames and Aaron J. Myers in Educational and Psychological Measurement
Pre-Post-Myth: How Cyberpunk Games Were Never Post-Human At All (abstract)
Creators: name: Mummelthei, Victoria
Publisher: name: Mythological Game Studies Conference, 22–23 Mai, 2025, online
Year: 2025
Subjects: game studies
video games
digital games
myth
mythological
computer games
cyberpunk
posthuman

description: Accepted contribution for Mythological Game Studies Conference, online, 22–23 Mai, 2025.
Williamson_Supplemental_Material_rev – Supplemental material for Early Effects of the COVID-19 Pandemic on Relationship Satisfaction and Attributions
Creators: name: Williamson, Hannah C.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, Williamson_Supplemental_Material_rev for Early Effects of the COVID-19 Pandemic on Relationship Satisfaction and Attributions by Hannah C. Williamson in Psychological Science
COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exception-A Systematic Review
Creators: name: Kulasekara Wijeratne
name: Crewther, Sheila
name: Sales, Carmela
name: Karimi, Leila
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Clinical reports of neurological manifestations associated with severe coronavirus disease 2019 (COVID-19), such as acute ischemic stroke (AIS), encephalopathy, seizures, headaches, acute necrotizing encephalitis, cerebral microbleeds, posterior reversible leukoencephalopathy syndrome, hemophagocytic lymphohistiocytosis, peripheral neuropathy, cranial nerve palsies, transverse myelitis, and demyelinating disorders, are increasing rapidly. However, there are comparatively few studies investigating the potential impact of immunological responses secondary to hypoxia, oxidative stress, and excessive platelet-induced aggregation on the brain. This scoping review has focused on the pathophysiological mechanisms associated with peripheral and consequential neural (central) inflammation leading to COVID-19-related ischemic strokes. It also highlights the common biological processes shared between AIS and COVID-19 infection and the importance of the recognition that severe respiratory dysfunction and neurological impairments associated with COVID and chronic inflammation [post-COVID-19 neurological syndrome (PCNS)] may significantly impact recovery and ability to benefit from neurorehabilitation. This study provides a comprehensive review of the pathobiology of COVID-19 and ischemic stroke. It also affirms that the immunological contribution to the pathophysiology of COVID-19 is predictive of the neurological sequelae particularly ischemic stroke, which makes it the expectation rather than the exception. This work is of fundamental significance to the neurorehabilitation community given the increasing number of COVID-related ischemic strokes, the current limited knowledge regarding the risk of reinfection, and recent reports of a PCNS. It further highlights the need for global collaboration and research into new pathobiology-based neurorehabilitation treatment strategies and more integrated evidence-based care.
Supplemental_table_1_NOS_for_non-FDA_label_DOAC_use_FINAL_1 – Supplemental material for Off-label Use for Direct Oral Anticoagulants: Valvular Atrial Fibrillation, Heart Failure, Left Ventricular Thrombus, Superficial Vein Thrombosis, Pulmonary Hypertension—a Systematic Review
Creators: name: Brokmeier, Hannah
name: Kido, Kazuhiko
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, Supplemental_table_1_NOS_for_non-FDA_label_DOAC_use_FINAL_1 for Off-label Use for Direct Oral Anticoagulants: Valvular Atrial Fibrillation, Heart Failure, Left Ventricular Thrombus, Superficial Vein Thrombosis, Pulmonary Hypertension—a Systematic Review by Hannah Brokmeier and Kazuhiko Kido in Annals of Pharmacotherapy
Phytochemical profiles and evaluation of the biological potential of ethyl acetate and n-butanol fractions of the aerial parts of Cistus albidus L
Creators: name: Gherboudj, Ouissem
name: Boutaghane, Naima
name: Kabouche, Zahia
name: Djeblia, Lamia
name: Zerrougui, Leila
name: Bekrar, Manel
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Hematology
subject: Plant Biology

description: The phytochemical profiles of the ethyl acetate (EAFCA) and n-butanol (BFCA) fractions of the aerial parts of Cistus albidus L., were characterised by a developed LC-ESI-MS/MS method, using 53 fingerprint phytochemicals, revealing the presence of 26 and 22 compounds, respectively with quinic acid, gallic acid, protocatechuic acid, catechin, gentisic acid, tannic acid, ellagic acid, quercitrin, astragalin as the major compounds of the EAFCA, in very higher amounts than in the BFCA. The antioxidant activity was evaluated using six methods (DPPH•, ABTS•+, GOR•, CUPRAC, FRAP and Phenanthroline). In agreement with its highest polyphenolic content (430.12 ± 1.02 µg GAE/mg of extract) and largest amounts of identified polyphenolics, the EAFCA exhibited a higher antioxidant activity than the BFCA. Additionally, the EAFCA showed the highest acetylcholinesterase (AChE) inhibition (IC50 of 25.1 ± 2.58 µg/mL). Moreover, both EAFCA and BFCA demonstrated high photoprotective activity, with sun protection factor (SPF) values of 36.49 and 36.52, respectively.
AOP-20-0476_Supplemental_Table_1_1 – Supplemental material for Economic Burden of Osteoporosis-Related Fractures in the US Medicare Population
Creators: name: Williams, Setareh A.
name: Shanette G. Daigle
name: Weiss, Richard
name: Yamei Wang
name: Arora, Tarun
name: Curtis, Jeffrey R.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, AOP-20-0476_Supplemental_Table_1_1 for Economic Burden of Osteoporosis-Related Fractures in the US Medicare Population by Setareh A. Williams, Shanette G. Daigle, Richard Weiss, Yamei Wang, Tarun Arora and Jeffrey R. Curtis in Annals of Pharmacotherapy
Phaenobezzia Haeselbarth 1965
Creators: name: Borkent, Art
name: Evenhuis, Neal L.
name: Dominiak, Patrycja
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Phaenobezzia

description: Genus PHAENOBEZZIA Haeselbarth
scipioprimoris Saha, Pal, Brahma & Hazra, 2022: 5. India.
umbra Saha, Pal, Brahma & Hazra, 2022: 3. India.
description: Published as part of Borkent, Art, Evenhuis, Neal L. & Dominiak, Patrycja, 2025, The World Catalog of Biting Midges (Diptera: Ceratopogonidae): Additional Updates and Errata, pp. 245-268 in Zootaxa 5631 (2) on page 261, DOI: 10.11646/zootaxa.5631.2.2, http://zenodo.org/record/15370558
Additional file 1 of Clinical significance of retained products of conception in placenta previa: a retrospective analysis
Creators: name: Kishimoto, Naohisa
name: Miyamoto, Morikazu
name: Imauji, Akari
name: Takada, Minori
name: Nishitani, Soko
name: Tanabe, Risa
name: Ito, Tsubasa
name: Hada, Taira
name: Otsuka, Yuka
name: Takano, Masashi
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supplementary material 1. The details of cases with retained products of conception (RPOC)with severe postpartum hemorrhage in pregnant patients with placenta previa.