cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Organizational Design of an IT-based Knowledge System: The NetAcademy Concept
Creators: name: Schubert, Petra
name: Selz, Dorian
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 1998
Subjects: subject: Wissensmanagement
subject: Knowledge Management
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: The emergence of new media channels such as the World Wide Web has induced a profound growth in the publication of books, papers, pictures and hypertext documents. In addition to forming a large knowledge base, the NetAcademy (NA) is meant to provide a meeting place for the joint discussion of trends, the exchange of personal opinions and research results within a specific scientific field of research or interest.Building up a compound knowledge system does not only require an adequate design and good technological implementation it involves also permanent engagement from a core of people responsible for news update, reviewing and feedback response. A smooth integration and automation of processes is therefore a key prerequisite for the successful maintenance and continuous attractiveness of the system.The paper describes the realization of the NetAcademy platform dealing with its template-based design and the combination of different software tools such as e.g.
Characterization of the role of the medial prefrontal cortex and the amygdala in fear and anxiety: a focus on bombesin-like peptides and corticotropin-releasing hormone
Creators: name: Mountney, Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Neuroscience.
subject: Psychology, Psychobiology.

description: This dissertation aimed to more fully characterize the involvement of bombesin-like peptides (neuromedin-B [NMB] and gastrin-releasing peptide [GRP]) and corticotropin-releasing hormone (CRH) in fear and anxiety-related processes. To this end, ventricularly injected GRP and antagonists of the NMB receptor decreased fear and/or anxiety across several animal models of behavior. Whereas NMB appeared to be involved in both fear and anxiety-related processes, GRP affected fear-related processes. In order to determine where in the brain these effects might be primarily localized, several neurochemical alterations were assessed in brain areas known to be involved in fear. Endogenous alterations in peptide levels were seen both within the medial prefrontal cortex (mPFC) and amygdala in response to recall of a fear-inducing shock. To explore this finding further, GRP or its receptor antagonist were microinjected into specific nuclei in the aforementioned areas and it was found that GRP consistently reduced fear at these loci, while the receptor antagonist exhibited both agonistic (reduced freezing) effects as well as antagonistic effects (increased freezing). Further, the observed reductions in freezing appeared to be specific to contextual components of conditioned fear, with the exception of drug administration to the infralimbic (IL) cortex within the mPFC, where we saw reduced freezing to a conditioned tone as well. To determine the endogenous release of GRP and CRH in response to conditioned fear, we collected dialysates from the IL of the mPFC and basolateral amygdala (BLA) in response to a previously conditioned tone. GRP and CRH were elevated 24h after fear conditioning at the BLA, an effect that appears to be related to animal's levels of fear. This was not observed at the IL. Finally, we explored whether the mPFC and amygdala communicated with each other via GRP and/or CRH through a GRP-specific pathway(s). We found that there appears to be a functional pathway between the IL cortex and BLA that is specific to GRP but not to CRH, upon manipulation of IL GRP levels. These studies have further characterized the role of BLPs and CRH in conditioned fear, particularly at the level of the mPFC and BLA and have provided a unique and rich foundation for the physiological role of these peptides and future studies to be developed.
Fallstudie Triamun
Creators: name: Schubert, Petra
Publisher: name: Hanser
Year: 2003
Subjects: subject: E-Business
subject: Integration
subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Die Triamun AG bietet Software für das Gesundheitswesen, die sich in erster Linie an Apotheken und Arztpraxen richtet. Die Fallstudie zeigt, dass der Ansatz von Application Service Providing für KMU eine geeignete Lösung darstellen kann ? sogar am Point of Sale, wo es auf schnelle Antwortzeiten ankommt. Die Triamun-Lösung ist eine kollaborative Plattform, an die andere Parteien des Gesundheitswesens (Clearingstellen, Pharma-Grossisten, Labors, etc.) elektronisch angeschlossen sind.
Income Generating Activities of People Who Inject Drugs
Creators: name: DeBeck, Kora
name: Shannon, K.
name: Wood, Evan
name: Li, Kathy
name: Montaner, Julio
name: Kerr, Thomas
Publisher: name: The University of British Columbia
Year: 2017

description: Background Injection drug users (IDU) commonly generate income through prohibited activities, such as drug dealing and sex trade work, which carry significant risk. However, little is known about the IDU who engage in such activities and the role of active drug use in perpetuating this behavior. Methods We evaluated factors associated with prohibited income generation among participants enrolled in the Vancouver Injection Drug Users Study (VIDUS) using logistic and linear regression. We also examined which sources of income respondents would eliminate if they did not require money to pay for drugs. Results Among 275 IDU, 145 (53%) reported engaging in prohibited income generating activities in the past 30 days. Sex work and drug dealing accounted for the greatest amount of income generated. Non-aboriginal females were the group most likely to report prohibited income generation. Other variables independently associated with prohibited income generation include daily heroin injection (AOR = 2.3) and daily use of crack cocaine (AOR = 3.5). Among these individuals, 68 (47%) indicated they would forgo these earnings if they did not require money for illegal drugs, with those engaged in sex trade work (62%) being most willing to give up their illegal source of income. Conclusion These findings suggest that the costs associated with illicit drugs are compelling IDU, particularly those possessing markers of higher intensity addiction, to engage in prohibited income generating activities. These findings also point to an opportunity to explore interventions that relieve the financial pressure of purchasing illegal drugs and reduce engagement in such activities, such as low threshold employment and expansion of prescription and substitution therapies.
NODES_Inndiana_Z11_Microbioma è la chiave dell'obesità? Si/No è solo un'ipotesi
Creators: name: University of Eastern Piedmont Amadeo Avogadro
Publisher: name: Zenodo
Year: 2024
Subjects: Spoke 5 - Industry for Health and Silver Economy
INNDIANA Project
Eco healthcare
ECS00000036

description: Congresso Conguinto SID-AMD-SIEDP-SIE-ANIED-OSDI
A Strategy for Efficient Crawling of Rich Internet Applications
Creators: name: Benjamin, Kamara
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Computer Science.

description: This thesis studies the problem of crawling rich internet applications. These applications are built using advanced web technologies which allow them to be more dynamic and enable better user experiences. In recent years, the popularity and importance of web applications has continually increased and they are now very commonly used to complete essential tasks such as financial transactions. As a result, the need to crawl these applications goes beyond the desire to index content for search. For example, applications also need to be analyzed in order to detect security vulnerabilities and assess accessibility. In this thesis, the challenges involved with crawling rich internet applications are discussed and an efficient strategy for crawling these applications is presented. We also use this strategy to develop a prototype tool for crawling AJAX-based applications.
Cost-Benefit Analysis of Timed A.I. and Natural Service in Beef Cattle
Creators: name: Griffith, Andrew P.
name: Boyer, Christopher N.
name: Rhinehart, Justin D.
name: Carter, Courtney
name: Griffith, Andrew P.
name: Boyer, Christopher N.
name: Rhinehart, Justin D.
name: Carter, Courtney
Publisher: name: Unknown
Year: 2020
Subjects: subject: Farm Management
subject: Financial Economics
subject: Livestock Production/Industries
subject: cost
subject: benefit
subject: analysis
subject: timed
subject: artificial
subject: insemination
subject: beef
subject: reproduction

description: Cattle breeders have long used natural service (NS) breeding (i.e., live bulls breeding cows as they naturally show heat), and it remains the predominant practice for most cow-calf producers. However, many cattle breeders have embraced the use of reproductive technologies such as artificial insemination (AI), estrus synchronization (ES) and embryo transfer (ET). The use of AI — more specifically timed AI (TAI; synchronized estrus to inseminate all cows in a group at the same time) — has garnered increased attention from seedstock and commercial producers over the past decade. There are several reasons producers have adopted AI including: • Access to genetics from sires that are cost prohibitive if purchasing a bull for natural service. • Selecting genetics from multiple bulls to complement individual cows in the same mating group. • Owning and managing fewer bulls. • Narrowing the time frame of calving for the herd. TAI has been widely adopted in beef production because it offers the benefits of AI, while reducing and concentrating the quantity of labor related to estrous detection (“checking heat”). Moreover, the modern ES protocols for TAI can shorten the calving season while increasing overall calving rate. Even with these positive attributes, and numerous other benefits, many producers still view TAI as cost prohibitive. Thus, it is imperative to compare the costs and benefits for both TAI and NS to determine which breeding program is the most ideal for a given scenario. Given the production benefits from TAI mentioned above, a clear indication of whether the production benefits exceed additional costs should be reached before deciding to implement this breeding technology in an operation. The objective of this paper is to compare the costs and revenues resulting from TAI against the costs and revenues resulting from NS breeding systems. These attributes will be compared across different size operations and across the typical range of pregnancy rates expected from application of a single TAI to begin the breeding season.
METHODOLOGY FOR CALCULATING THE COSTS OF DEVELOPING, IMPLEMENTING AND OPERATING AN INFORMATION RESOURCE SYSTEM FOR MANAGING INDUSTRIAL ENTERPRISES
Creators: name: Bahadirov, Iles
name: Umarov, Rahim
name: Pulatova, Zarifa
name: Bobokhonova, Mukhtaram
Publisher: name: Zenodo
Year: 2024

description: The modern world can be characterized by a time of increasing changes. The consequences of the scientific and technological revolution, expressed in the widespread use of advanced information technologies, have had an unprecedented impact on all spheres of human life. Perhaps the strongest consequences of such changes have been caused in modern business.
Real time curriculum map for internal medicine residency
Creators: name: Wong, Roger Y
name: Roberts, J M
Publisher: name: BioMed Central
Year: 2015

description: Background: To manage the voluminous formal curriculum content in a limited amount of structured teaching time, we describe the development and evaluation of a curriculum map for academic half days (AHD) in a core internal medicine residency program. Methods We created a 3-year cyclical curriculum map (an educational tool combining the content, methodology and timetabling of structured teaching), comprising a matrix of topics under various specialties/themes and corresponding AHD hours. All topics were cross-matched against the ACP-ASIM in-training examination, and all hours were colour coded based on the categories of core competencies. Residents regularly updated the map on a real time basis. Results There were 208 topics covered in 283 AHD hours. All topics represented core competencies with minimal duplication (78% covered once in 3 years). Only 42 hours (15%) involved non-didactic teaching, which increased after implementation of the map (18–19 hours/year versus baseline 5 hours/year). Most AHD hours (78%) focused on medical expert competencies. Resident satisfaction (90% response) was high throughout (range 3.64 ± 0.21, 3.84 ± 0.14 out of 4), which improved after 1 year but returned to baseline after 2 years. Conclusion We developed and implemented an internal medicine curriculum map based on real time resident input, with minimal topic duplication and high resident satisfaction. The map provided an opportunity to balance didactic versus non-didactic teaching, and teaching on medical versus non medical expert topics.
La Mesure: Relationships of Love and Communication in the "Lais" of Marie de France
Creators: name: Steffler, Micah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Literature, English.

description: This project examines the Lais of Marie de France with specific focus on "Chevrefoil," "Laustic," "Milun," and "Eliduc." The view of the relationship between orality and textuality as a linear chronological development is called into question in the light of Marie's devotion to mesure. The association between the oral and written traditions of storytelling is shown to be based on mutual co-dependency instead of a hierarchy by which the written tradition is deemed a superior mode of communication. Mesure is crucial to the maintenance of balance in this relationship, and appears in further aspects of the Lais, including the language; the connections between writing, reading, and performance; and relationships between characters. To achieve the status of fine amur, the partners in a romantic relationship must possess mesure. Lovers must value each other as equals, or a hierarchy introduces demesure into the relationship. This project reveals Marie's dedication to the importance of sustaining mesure in the face of temptation to indulge in demesure.
Speech Audio Archives: Preservation, Restoration, Annotation aimed at supporting the linguistic analysis
Creators: name: Amedeo, De Dominicis
Publisher: name: Zenodo
Year: 2018

description: CURATELA degli ATTI del CONVEGNO e organizzazione del convegno: De Dominicis Amedeo (ed.) Speech Audio Archives: Preservation, Restoration, Annotation aimed at supporting the linguistic analysis. pp. 7-10, ROMA: Bardi, 2018. ISBN: 978-88-218-1165-4, (Atti del Convegno svoltosi a Roma, Accademia dei Lincei, 18-19 maggio 2017).
Gut microbial changes associated with obesity in youth with type 1 diabetes: a Pilot Study: SUPPLEMENTARY MATERIAL
Creators: name: Javornik Cregeen, Sara
name: M Ismail, Heba
name: Perera, Dimuthu Nuwan
name: Mandal, Rabindra
name: A DiMeglio, Linda
name: Evans-Molina, Carmella
name: Hannon, Tamara S.
name: Petrosino, Joseph F.
name: Schmidt, Nathan W.
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: This study aims to describe the gut microbiome and microbial metabolite changes associated with obesity in T1D. We hypothesised significant gut microbial and metabolite differences between T1D youth who are lean (BMI: 5-<85%) vs. those with obesity (BMI: ≥95%). We analyzed stool samples for gut microbial (using metagenomic shotgun sequencing) and short-chain fatty acid (SCFA) metabolite differences in lean (n=27) and obese (n=21) T1D youth in a pilot study. Our findings identify a gut microbiome and microbial metabolite signature associated with obesity in T1D. These findings could help identify gut microbiome targeted therapies to manage obesity in T1D.
Report. European museums
Creators: name: Recuero-Virto, Nuria
Publisher: name: Zenodo
Year: 2024

description: This report is associated with the following publication:

Recuero-Virto, N. R., Blasco López, M. F. , & San-Martín, S. (2017). How can European museums reach sustainability? Tourism Review, 72(3), 303–318. https://doi.org/10.1108/tr-03-2017-0038

For more information, please visit: https://doi.org/10.1108/tr-03-2017-0038
Poly-G/poly-C tracts in the genomes of Caenorhabditis
Creators: name: Zhao, Yang
name: O'Neil, Nigel J
name: Rose, Ann M
Publisher: name: BioMed Central
Year: 2015

description: Background: In the genome of Caenorhabditis elegans, homopolymeric poly-G/poly-C tracts (G/C tracts) exist at high frequency and are maintained by the activity of the DOG-1 protein. The frequency and distribution of G/C tracts in the genomes of C. elegans and the related nematode, C. briggsae were analyzed to investigate possible biological roles for G/C tracts. Results In C. elegans, G/C tracts are distributed along every chromosome in a non-random pattern. Most G/C tracts are within introns or are close to genes. Analysis of SAGE data showed that G/C tracts correlate with the levels of regional gene expression in C. elegans. G/C tracts are over-represented and dispersed across all chromosomes in another Caenorhabditis species, C. briggsae. However, the positions and distribution of G/C tracts in C. briggsae differ from those in C. elegans. Furthermore, the C. briggsae dog-1 ortholog CBG19723 can rescue the mutator phenotype of C. elegans dog-1 mutants. Conclusion The abundance and genomic distribution of G/C tracts in C. elegans, the effect of G/C tracts on regional transcription levels, and the lack of positional conservation of G/C tracts in C. briggsae suggest a role for G/C tracts in chromatin structure but not in the transcriptional regulation of specific genes.
A STUDY ON THE ADVANCED APPLICATION OF GEOTEXTILES IN PAVEMENT  DESIGN
Creators: name: Bhat, Mohmmad Farooq
name: Rathore, Richika
Publisher: name: Zenodo
Year: 2022

description: The various geosynthetic products have the broadest range of properties that will strengthen the pavement design by adhering to the strict nomenclature associated with geotextile materials. Considerable increase in length of roads in India has increased the necessity of rapid, economic and sustainable construction methodologies. Thus, at various construction stages of pavement the use of additives has gained significance over the period of time. Geotextiles are an important product for increasing the strength of the soil subgrade. The use of geotextiles in soil subgrade pavements has resulted in a massive increase in the value of geotextile products. This improves not only the strength but also the drainage characteristics of the soil subgrade. Keeping the use of geotextile in pavement application in mind, it can be divided into several parameters such as separation, filtration, drainage, reinforcement, and mitigation. Geotextile also functions as a permeable synthetic textile material. This Study involves a stretch of village road in Ganderbal district. CBR tests were conducted on the virgin soil and soils with geotextiles to see the improvement in the CBR values. The geotextiles were placed at the depth of 1.5 cm, 3 cm, 4.5 cm 7 cm and 8.5 cm.  The values of CBR improved from 3.15 % to 5.61% for 4.5 cm depth of geotextile. On the test section of the road geotextile was introduced between subgrade and sub-base and field test, DCP was performed to evaluate the penetration of geotextile road and compare it with non-geotextile road. The average values obtained for test road section with and without geotextiles are 5.44mm/blow and 6.05mm/blow respectively.
On the History of Water Coagulation
Creators: name: Al Azharia Jahn, Samia
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Water coagulation is one of the standard methods used by modern water works for the treatment of drinking and waste water. Most laymen and engineers in the Western world believe that this technology was invented by Europeans sometime in the 19th or early 20th century. However, in tropical developing countries, the clarification of turbid waters from rivers, lakes and water holes is an old household method, although only a few traditional materials act as primary coagulants. Seeds of Moringa oleifera containing basic poplypeptides are currently the most promising plant material for utilisation in water supplies. These seeds were detected by Sudan Arab village women at the beginning of the 20th century as substitutes for less efficient beans and groundnuts (Jahn 1981 and 1986). The oldest records of a precursor of these seeds are from ancient India (1st century A.D.). European eyewitnesses reported related water clarification methods in Egypt at the end of the 16th century and China at the end of the 17th century (Baker 1948: 300,302). Striking similarities between the Indian and Egyptian methods of applying a flocculating plant material have already been pointed out (Jahn 1988a: 172), but historical data from Chinese archives have not been considered to date. According to some notes, the author recently obtained from Beijing and Taipei, attempts at water clarification have been reported in China since the 2nd century A.D. The present paper aims at investigating how the Chinese were involved in the transfer of knowledge and contributed to new developments. The work is based on studies of literature, correspondence with historians, and laboratory and field research on traditional water coagulation in the Sudan and other tropical countries in Africa, Asia and Latin America. The historical data are critically analysed from various points of view. Special attention has been paid to the role of religions, their codes of law and local concepts of water treatment. The transliteration of Sanscrit, Arabic and Mandarin is done in various ways. In the present paper it corresponds to the method used by the authors quoted or the informants in their books, articles or personal communications, but special phonetic signs have been omitted to avoid difficulties in printing. As far as Chinese words are concerned, the different systems of transliteration can be compared in a guide by Legeza (1968-69).
description: ASIEN: The German Journal on Contemporary Asia, Nr. 50 (1994): ASIEN (Januar)
Zu den japanisch-mongolischen Beziehungen der letzten Jahre
Creators: name: Barkmann, Udo B.
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Japan ist in den letzten Jahren von den USA und den Staaten der Europäischen Gemeinschaft verschiedentlich aufgefordert worden, sich nicht ausschließlich als wirtschaftliche Macht zu verstehen, sondern sich als Weltmacht stärker in die politische Verantwortung einzubringen. Wenn man jedoch z. B. die mongolisch-japanischen Beziehungen analysiert, gewinnt man sehr wohl den Eindruck eines starken politischen Engagements Japans, das sich allerdings nicht so laut und vordergründig als ein solches postuliert. Japanische Politik setzt auf die leisen Töne und nicht auf effektvolle Großtuerei, ist deshalb aber nicht weniger wirkungsvoll. Sie ist psychologisch kalkuliert und weniger an der Tagespolitik denn an mittel- und langfristigen Strategien orientiert. Japanische Politik kennt Elemente, die der europäischen und amerikanischen fremd zu sein scheinen: Geduld und ein gewisses Maß an innerer Harmonie, das Statik gebiert. [...]
description: ASIEN: The German Journal on Contemporary Asia, Nr. 50 (1994): ASIEN (Januar)
Role of Japanese Foreign Direct Investment and Technology
Creators: name: Köllner, Patrick
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: The present study aims at highlighting some aspects of the inter-relationship between South Korea’s economic development strategies and ensuing government policies vis-à-vis foreign direct investment (FDI) and technology transfer (TT) on the one hand and the inflow of Japanese direct investment on the other hand. One of the salient features of the Japanese-Korean economic relationship is the fact that Japan has been the biggest provider of FDI and TT since the normalisation of relations in 1965. Over the same period policy-makers in Korea tried to control and guide the inflow of capital and technology so that it would not only facilitate industrial development in the direction desired by the government but also help to nurture domestic entrepreneurs. Changing government perceptions of FDI and TT and policies and regulations in this field have thus to be seen against the background of changes in the prevailing development strategies in the past three decades. [...]
description: ASIEN: The German Journal on Contemporary Asia, Nr. 50 (1994): ASIEN (Januar)
Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
Creators: name: Thibodeau, Isabelle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: Atrial Fibrillation (AF), the most common sustained cardiac arrhythmia, is a disease that affects the electrical conductance in the atria. Gap junction channels, composed of connexin (Cx) proteins, allow the electrical signal to propagate between cardiac myocytes. Mutations in two highly expressed cardiac connexin genes, GJA1 (Cx43) and GJA5 (Cx40), have been identified by our group in a cohort of patients with lone AF. To characterize trafficking of a novel somatic frameshift Cx43 mutant and three novel Cx40 mutants, fluorescently tagged connexins were visualized in HeLa cells using confocal microscopy. Electrophysiological studies were performed by a member of our lab to test the function of mutant gap junction channels. The Cx43 frameshift mutant (Cx43-932delC) caused intracellular retention of Cx43, resulting in impaired electrical coupling between paired cells. All three Cx40 mutants (F30L, G311S and R113S) demonstrated normal trafficking and electrical coupling between paired N2A cells. Enhanced hemichannel function was observed for the Cx40-F30L mutant, leading to cell death in Xenopus oocytes. Increased sensitivity to intracellular pH caused closure of gap junction channels composed of Cx40-G311S or Cx40-R113S. Intracellular localization of a previously published Cx40 mutation (P88S) was determined to be retained within the ER and Golgi compartments. Trafficking rescue was observed when P88S was co-expressed with wild-type Cx40 or Cx43. My results and those of our collaborators demonstrate a novel finding that a Cx43 mutation is associated with AF and also further support reported findings on the association of Cx40 mutations with AF.
Oligonucleotide Array Comparative Genomic Hybridization (oaCGH) based characterization of genetic deficiencies as an aid to gene mapping in Caenorhabditis elegans
Creators: name: Jones, Martin R.
name: Maydan, Jason S.
name: Flibotte, Stephane
name: Moerman, Donald G.
name: Baillie, David L.
Publisher: name: BioMed Central
Year: 2016

description: Background: A collection of genetic deficiencies covering over 70% of the Caenorhabditis elegans genome exists, however the application of these valuable biological tools has been limited due to the incomplete correlation between their genetic and physical characterization. Results: We have applied oligonucleotide array Comparative Genomic Hybridization (oaCGH) to the high resolution, molecular characterization of several genetic deficiency and duplication strains in a 5 Mb region of Chromosome III. We incorporate this data into a physical deficiency map which is subsequently used to direct the positional cloning of essential genes within the region. From this analysis we are able to quickly determine the molecular identity of several previously unidentified mutations. Conclusion: We have applied accurate, high resolution molecular analysis to the characterization of genetic mapping tools in Caenorhabditis elegans. Consequently we have generated a valuable physical mapping resource, which we have demonstrated can aid in the rapid molecular identification of mutations of interest.
The costs of preventing the spread of respiratory infection in family physician offices: a threshold analysis
Creators: name: Hogg, William
name: Gray, David
name: Huston, Patricia
name: Zhang, Wei (Health Economist)
Publisher: name: BioMed Central
Year: 2015

description: Background: Influenza poses concerns about epidemic respiratory infection. Interventions designed to prevent the spread of respiratory infection within family physician (FP) offices could potentially have a significant positive influence on the health of Canadians. The main purpose of this paper is to estimate the explicit costs of such an intervention. Methods A cost analysis of a respiratory infection control was conducted. The costs were estimated from the perspective of provincial government. In addition, a threshold analysis was conducted to estimate a threshold value of the intervention's effectiveness that could generate potential savings in terms of averted health-care costs by the intervention that exceed the explicit costs. The informational requirements for these implicit costs savings are high, however. Some of these elements, such as the cost of hospitalization in the event of contacting influenza, and the number of patients passing through the physicians' office, were readily available. Other pertinent points of information, such as the proportion of infected people who require hospitalization, could be imported from the existing literature. We take an indirect approach to calculate a threshold value for the most uncertain piece of information, namely the reduction in the probability of the infection spreading as a direct result of the intervention, at which the intervention becomes worthwhile. Results The 5-week intervention costs amounted to a total of $52,810.71, or $131,094.73 prorated according to the length of the flu season, or $512,729.30 prorated for the entire calendar year. The variable costs that were incurred for this 5-week project amounted to approximately $923.16 per participating medical practice. The (fixed) training costs per practice were equivalent to $73.27 for the 5-week intervention, or $28.14 for 13-week flu season, or $7.05 for an entire one-year period. Conclusion Based on our conservative estimates for the direct cost savings, there are indications that the outreach facilitation intervention program would be cost effective if it can achieve a reduction in the probability of infection on the order of 0.83 (0.77, 1.05) percentage points. A facilitation intervention initiative tailored to the environment and needs of the family medical practice and walk-in clinics is of promise for improving respiratory infection control in the physicians' offices.
Η Θεωρία του κλινικού Αυτοπροσδιορισμού Vandoros 2025
Creators: name: VANDOROS, ANDREAS
Publisher: name: Zenodo
Year: 2025
Subjects: Αυτοπροσδιορισμός , Προστασία,Ηθική,Κλινική ταυτότητα Αυτοπροσδιορισμός
Nursing Theories

description: Η "Θεωρία του Κλινικού Αυτοπροσδιορισμού" προσφέρει μια καινοτόμο ερμηνευτική προσέγγιση στον ρόλο του νοσηλευτή στον κλινικό χώρο, αμφισβητώντας τις παραδοσιακές ιεραρχίες που τον τοποθετούν ως παθητικό εκτελεστή ιατρικών οδηγιών. Βασική αρχή της θεωρίας είναι ότι ο νοσηλευτής αποτελεί έναν αυτόνομο και κυρίαρχο επαγγελματία, ο οποίος κατέχει έναν θεμελιώδη ρόλο στη διαμόρφωση, άσκηση και υπεράσπιση της κλινικής πράξης. Μέσω αυτής της θεωρίας, η παρουσία του νοσηλευτή αναδεικνύεται ως ο θεσμικός και υπαρξιακός πυρήνας γύρω από τον οποίο συγκροτείται η θεραπευτική κοινότητα.

Η θεωρία εισάγει επίσης τη έννοια της "κλινικής ασυλίας", υπογραμμίζοντας την ανάγκη για ένα προστατευτικό πλαίσιο που να προλαμβάνει και να αποτρέπει κάθε μορφή λεκτικής, σωματικής ή ψυχολογικής βίας από τους ασθενείς. Παράλληλα, αναδεικνύει την ανάγκη για μια οργανωτική προσέγγιση της αντιμετώπισης επαγγελματικών λαθών, προτείνοντας ένα σύστημα κατ' αναλογία με την κοινοβουλευτική ασυλία.

Η θεωρία αυτή προσφέρει ένα νέο μοντέλο επαγγελματικής ταυτότητας για τους νοσηλευτές, βασισμένο στην ενδυνάμωση, την αυτονομία και τη θεσμική αναγνώριση του ρόλου τους στον 21ο αιώνα, ενώ προσφέρει επίσης φωνή στους σύγχρονους επαγγελματίες υγείας που επιθυμούν να εκφράσουν σκέψεις και να αμφισβητήσουν το υφιστάμενο σύστημα.
Wntbeta-catenin Signaling in Development of the Ciliary Margin in the Murine Eye
Creators: name: Ha, Andrew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: The ciliary body (CB) of the vertebrate eye is located in the peripheral region of the retina and is involved in lens accommodation and production of aqueous humor. The CB develops from the ciliary margin (CM) where non-neural epithelial tissue differentiates from the neural ectoderm during embryonic development. The CM/CB represents an interesting area of study since the pigmented layer of the CM is reported to accommodate a pool of adult retinal stem cells. In fish and amphibians, these stem cells facilitate retinal growth and replenishment although this has yet to be observed in the mammalian retina. Previous studies have reported that the canonical Wnt signaling pathway has a role in development of the CM. Activation of this pathway both in vitro and in vivo resulted in an increase of CM markers at the expense of neural retinal markers and also resulted in an inhibition of neurogenesis in the retina. In this study, I show a preliminary screen of genes that playa role in Wnt mediated development of the CM. Using microarray analysis, quantitative real-time PCR, and in situ hybridization, I have identified candidate Wnt target genes in addition to known effectors of Wnt signaling in CM development. Additionally, I have begun a preliminary investigation to elucidate the role of the CM marker, Msx1, as a potential Wnt effector in CM development by showing that expression of this gene results in the downregulation of several bHLH transcription factors that are required for retinal neurogenesis. These findings provide some insights in how CM development is regulated by effectors of Wnt signaling.
Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
Creators: name: Prentice, Leah M.
name: Klausen, Christian
name: Kalloger, Steve
name: Köbel, Martin
name: McKinney, Steven
name: Santos, Jennifer L.
name: Kenney, Challayne
name: Mehl, Erika
name: Gilks, C. Blake
name: Leung, P. C. K.
name: Swenerton, Ken
name: Huntsman, David G.
name: Aparicio, Samuel, 1963-
Publisher: name: BioMed Central
Year: 2015

description: Background: Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems. The latter might suggest that their overexpression would be associated with a better prognosis in cancer. However, kisspeptin/GPR54 interactions (autocrine, paracrine, and/or endocrine) could also impact tumour behaviour in a negative manner. Here, for the first time, we associate the immunoreactivity of the kisspeptin/GPR54 ligand-receptor pair with favourable prognosis in a large cohort of ovarian carcinomas. Methods Immunohistochemical analysis for kisspeptin and GPR54 was performed on a tissue microarray (TMA) consisting of 518 early stage ovarian carcinomas, all with linked clinical outcome data. The TMA was scored using a staining intensity scale of 0 (negative), +1 (mild-moderate), and +2 (strong). Strong staining cases were considered either kisspeptin or GPR54 positive and designated as 1, while all other cases were considered negative and designated 0. All statistical analysis was conducted using two-sided tests and a p value equal to or less than 0.05 was considered significant. Results Kisspeptin and GPR54 immunoreactive cases show a favourable prognosis in univariable disease specific survival (p = 0.0023, p = 0.0092), as well as in overall survival (p = 0.0006, p = 0.0002). Furthermore, kisspeptin is an independent marker for favourable prognosis as determined by multivariable disease specific (p = 0.0046) and overall survival analysis (p = 0.0170), while GPR54 is an independent marker for overall survival only (p = 0.0303). Both kisspeptin positive and GPR54 positive cases are strongly associated with the ovarian carcinoma clear cell subtype (p < 0.0001, p < 0.0001), and GPR54 is significantly associated with favourable prognosis in overall survival within the clear cell subtype (p = 0.0102). Conclusion Kisspeptin and GPR54 immunoreactivity are significantly associated with favourable prognosis in both disease specific and overall survival, as well as being significantly associated with the clear cell ovarian carcinoma subtype, thereby creating the first independent prognostic biomarkers specific for ovarian clear cell carcinomas.
Distribution of a Global CO2 Budget - A Comparison of Resource Sharing Models
Creators: name: Sargl, Manfred
name: Wiegand, Daniel
name: Wittmann, Günter
name: Wolfsteiner, Andreas
Publisher: name: Zenodo
Year: 2021
Subjects: climate policy
Paris compatible emission paths
emission paths
CO2 budget
Paris agreement
resource sharing
burden sharing
effort sharing
ambition mechanism

description: In view of the connection between the cumulative CO2 emissions and global warming, as described e.g. in the IPCC Special Report October 2018, the key question arises how a globally remaining budget could be realistically distributed among countries. Discussion of this issue can contribute to NDCs that are, in sum, Paris compatible. Resource sharing models directly address the allocation of such a remaining global budget. This article will therefore give an overview of the properties of resource sharing models that, in principle, use current emissions and population as a distribution key.
title: Defying 4D gravity: novel searches for signatures of string theory via non-minimal dark sectors, scalar cascades, noncommutative black holes and deep learning
Creators: name: Villhauer, Elena
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: Standard Model
subject: gravity
subject: string theory
subject: Large Hadron Collider
subject: ATLAS experiment

description: The existence of extra dimensions could lower the fundamental Planck scale to the low TeV scale and very excitingly allow string theory to be probed at the LHC. This thesis presents novel searches for signatures of string theory via three models that have never been searched for by any experiment: scalar cascades, noncommutative black holes, and non-minimal dark sectors. This thesis includes the first-time exploration of a novel final state. Deep learning is employed through the use of particle flow networks to learn jet substructure and design analysis regions. The background estimation is automated through the implementation of distance correlation in the neural network loss function. A novel jet reclustering algorithm is used to overcome the challenges associated with a soft final state.
Distribution of a Global CO2 Budget - A Comparison of Resource Sharing Models
Creators: name: Sargl, Manfred
name: Wiegand, Daniel
name: Wittmann, Günter
name: Wolfsteiner, Andreas
Publisher: name: Zenodo
Year: 2023
Subjects: climate policy
Paris Ambition Mechanism
Paris compatible emission paths
emission paths
CO2 budget
resource sharing
burden sharing
effort sharing
Global Stocktake
NDCs
Paris Agreement

description: In view of the connection between the cumulative CO2 emissions and global warming, as described in the IPCC reports, the key question arises how a globally remaining budget could be realistically distributed among countries. The discussion of this issue can contribute to NDCs that are Paris-compatible in sum.

Resource sharing models directly address the allocation of such a remaining global budget. This article will therefore give an overview of the properties of resource sharing models that, in principle, use current emissions and population as a distribution key. With the current emissions, the current reality and with the population climate justice can be mapped.

We also identified a possible additional helpful assessment criterion for NDCs: the implicit weighting of population.
Monika Gänßbauer: Trauma der Vergangenheit - Die Rezeption der Kulturrevolution und der Schriftsteller Feng Jicai
Creators: name: Fecke, Claudia
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 66 (1998): ASIEN (Januar)
Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
Creators: name: MacRedmond, Ruth E
name: Greene, Catherine M
name: Dorscheid, Delbert R
name: McElvaney, Noel G
name: O'Neill, Shane J
Publisher: name: BioMed Central
Year: 2016

description: The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility to infection, while COPD is characterised by bacterial colonisation and infective exacerbations. We found reduced TLR4 gene expression in the nasal epithelium of smokers compared with non-smoking controls, while TLR2 expression was unchanged. Severe COPD was associated with reduced TLR4 expression compared to less severe disease, with good correlation between nasal and tracheal expression. We went on to examine the effect of potential modulators of TLR4 expression in respiratory epithelium pertinent to airways disease. Using an airway epithelial cell line, we found a dose-dependent downregulation in TLR4 mRNA and protein expression by stimulation with cigarette smoke extracts. Treatment with the corticosteroids fluticasone and dexamethasone resulted in a dose-dependent reduction in TLR4 mRNA and protein. The functional significance of this effect was demonstrated by impaired IL-8 and HBD2 induction in response to LPS. Stimulation with salmeterol (10-6 M) caused upregulation of TLR4 membrane protein presentation with no upregulation of mRNA, suggesting a post-translational effect. The effect of dexamethasone and salmeterol in combination was additive, with downregulation of TLR4 gene expression, and no change in membrane receptor expression. Modulation of TLR4 in respiratory epithelium may have important implications for airway inflammation and infection in response to inhaled pathogens.
Hai visto i Canadesi?: A study of the Social Interactions between Canadian Soldiers and Italian Civilians before, during, and after the Battle of Ortona
Creators: name: Cavasin, Zachary David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: History, European.
subject: History, Military.

description: This thesis is the first study to examine Canadian and Italian interactions in Ortona from December 1943 until April 1944. The Canadian presence in Ortona is not remembered by the people of the town simply in the context of military operations. As the Canadians occupied Ortona and the surrounding areas for four months, interactions occurred within the context of combat operations, periods of relaxation, and throughout the process of rebuilding infrastructure and developing an economy. Canadian military historians have largely neglected to provide accounts of the various engagements between Canadian soldiers and Italian civilians before, during, and after the Battle of Ortona, unless they affected operations, intelligence, and civil control. The result of these civil-military relationships provided numerous benefits to Canadian and Italian alike. Italians provided Canadian soldiers with intelligence, shelter, food, and psychological support. In turn, the Canadians provided the Italians with medical assistance, food, financial support, and technical support in the rebuilding of Ortona. The interactions promoted Canadians as separate from the other Allied forces in the region and created unique friendships that defined the liberator and the liberated through their mutual dependencies. As historians have focused entirely on the unfolding of military operations in the region of Ortona, this thesis argues that the value of the interactions and the reconstruction process help explain why most Ortonesi developed a positive collective memory of Canadian soldiers.
Distribution of a Global CO2 Budget - A Comparison of Resource Sharing Models
Creators: name: Sargl, Manfred
name: Wiegand, Daniel
name: Wittmann, Günter
name: Wolfsteiner, Andreas
Publisher: name: Zenodo
Year: 2021
Subjects: climate policy
Paris ambition mechanism
Paris compatible emission paths
emission paths
CO2 budget
Paris agreement
resource sharing
burden sharing
effort sharing

description: In view of the connection between the cumulative CO2 emissions and global warming, as described in the IPCC reports, the key question arises how a globally remaining budget could be realistically distributed among countries. Discussion of this issue can contribute to NDCs that are, in sum, Paris compatible. Resource sharing models directly address the allocation of such a remaining global budget. This article will therefore give an overview of the properties of resource sharing models that, in principle, use current emissions and population as a distribution key. With the current emissions, the current reality and with the population climate justice can be mapped. We also identified a possible additional helpful assessment criterion for NDCs: the implicit weighting of population.
Ursula Schrammel: Umweltschonende Technologien in Chinas Energiesektor - die Verwertung von Kraftwerksaschen
Creators: name: Oberheitmann, Andreas
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 66 (1998): ASIEN (Januar)
UZBEKISTAN ON THE PATH TO IMPROVING THE INVESTMENT CLIMATE
Creators: name: Davitova, Shahzoda
Publisher: name: Zenodo
Year: 2024

description: Uzbekistan, with its rich natural resources, strategic geographical location and economic reforms, has become an attractive center for foreign direct investment (FDI). The reforms implemented in order to support the country's investment environment and economic growth require a deep study of the theoretical and methodological foundations of FDI. The article anlyzes existing problems and gives own solutions.
Distribution of a Global CO2 Budget - A Comparison of Resource Sharing Models
Creators: name: Sargl, Manfred
name: Wiegand, Daniel
name: Wittmann, Günter
name: Wolfsteiner, Andreas
Publisher: name: Zenodo
Year: 2022
Subjects: climate policy
Paris ambition mechanism
Paris compatible emission paths
emission paths
CO2 budget
Paris agreement
resource sharing
burden sharing
effort sharing

description: In view of the connection between the cumulative CO2 emissions and global warming, as described in the IPCC reports, the key question arises how a globally remaining budget could be realistically distributed among countries. The discussion of this issue can contribute to NDCs that are Paris-compatible in sum. Resource sharing models directly address the allocation of such a remaining global budget. This article will therefore give an overview of the properties of resource sharing models that, in principle, use current emissions and population as a distribution key. With the current emissions, the current reality and with the population climate justice can be mapped. We also identified a possible additional helpful assessment criterion for NDCs: the implicit weighting of population.