cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Treat to Target in Systemic Lupus Erythematosus: Validation of the Lupus Low Disease Activity State
Creators: name: VERA GOLDER
Publisher: name: Monash University
Year: 2019
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: The focus of this PhD is on developing treat to target endpoints for systemic lupus erythematosus, an autoimmune multisystem disease that has devastating outcomes for afflicted patients, the majority of whom are women of childbearing age. The Lupus Low Disease Activity State (LLDAS) represents an attainable clinical treatment endpoint, attainment of which has now been proven to be associated with reduction in disease flares and accrual of irreversible end organ damage. The development of this endpoint has the potential to change clinical practice, as well as change the design and outcome in clinical trials of new therapies.
Grete Ring †
Creators: name: Friedländer, Max Jacob
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Bd. 5 Nr. 10 (1952): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
INTERNATIONAL RATE OF MANIAC SWITCHES WITH USE OF KETAMINE AND ESCETAMINE IN THE TREATMENT OF BIPOLAR DEPRESSION: A SYSTEMATIC REVIEW
Creators: name: Da Silva, Anderson Sousa Martins
name: Reifur, Lucas
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medicine and Health Sciences

description: Pre-project of the Specialization Course Completion Work in the modality of Medical Residency in Psychiatry by the Municipal Department of Health of São Bernardo do Campo/SP as a requirement for obtaining the degree of SPECIALIST IN PSYCHIATRY.
Analysis of the subsolar-mass black hole candidate SSM200308 from the second part of the third observing run of Advanced LIGO-Virgo
Creators: name: Prunier, Marine
name: Morrás, Gonzalo
name: Siles, José Francisco Nuño
name: Clesse, Sebastien
name: García-Bellido, Juan
name: Morales, Ester Ruiz
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: A follow-up of a subsolar black hole candidate identified in the second part of the third observing run of the LIGO-Virgo-KAGRA collaboration is carried out. With a search signal-to-noise ratio of $8.90$ and a false-alarm rate of 1 per 5 years, close to the usual thresholds for claiming a gravitational-wave event, we cannot exclude a noise origin. A complete Bayesian parameter estimation of this candidate, denoted SSM200308, reveals that if the signal originates from a compact binary coalescence, the component masses are $m_1= 0.62^{+0.46}_{-0.20} M_{\odot}$ and $m_2 = 0.27^{+0.12}_{-0.10} M_{\odot}$ (90% credible intervals) with at least one component being firmly subsolar, below the minimum mass of a neutron star. This discards the hypothesis that the signal comes from a standard binary neutron star. The signal coherence test between the two LIGO detectors brings support to a compact object coalescence origin.
description: 7 pages, 4 figures, comments welcome
The Seafarer
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 200301 Early English Languages
subject: FOS: Languages and literature
subject: 200503 British and Irish Literature

description: This is a translation of the first nineteen lines of the Old English poem The Seafarer; I chose this section as it forms a fairly coherent whole but still gives a strong sense of the atmosphere of the poem.
Bone Health Across the Spectrum of Chronic Kidney Disease and Renal Transplantation
Creators: name: JASNA ALEKSOVA
Publisher: name: Monash University
Year: 2019
Subjects: Medicine

description: Patients with chronic kidney disease (CKD) have exceptionally high fracture rates compared to the general population, with a significantly increased morbidity and mortality. However, the investigation and management of bone health in patients with CKD is currently suboptimal. This PhD examined novel risk factors for fracture in patients with CKD with a focus on the role of hypogonadism and fracture risk, and non-invasive imaging techniques to predict fractures in these patients. Gonadal dysfunction was common, but there was insufficient evidence to define and guide management options relating to gonadal function and bone outcomes. Novel, yet inexpensive and non-invasive imaging techniques were associated with prevalent fractures, and if validated in future prospective studies, their use will enhance current diagnostic algorithms for managing bone health in these patients.
Lambek Invariants of Commutative Squares in a Homological Category
Creators: name: Kopylov, Yaroslav
name: Leshkov, Vadim
Publisher: name: arXiv
Year: 2023
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18G50

description: We consider the Lambek invariants (introduced by Joachim Lambek in 1964) in the context of semiexact and homological categories in the sense of Grandis. We generalize the Lambek isomorphism theorem to semiexact and homological categories. Throughout the text, for completeness we give proofs of some lemmas which are known in the additive case for the case of semiexact and homological categories.
L’équipe opérationnelle d’hygiène a un rôle à jouer dans la transformation écoresponsable des soins
Creators: name: Meunier, Olivier
name: Gentner, Olivier
name: Jean-Marc Durrheimer
name: Klein, Céline
name: Burger, Sandrine
name: Garniche, Cécile
Publisher: name: Health & Co
Year: 2025
Subjects: Hygiène hospitalière
Transformation écologique
Programme de prévention
Vaccination
Environnement
Qualité de l’air
Qualité des eaux

description: Les missions de l’équipe opérationnelle d’hygiène au sein de l’hôpital lui permettent de jouer, par ses choix, ses validations et ses décisions, un rôle prescripteur fort pour un fonctionnement ou des soins plus éco­responsables. Nous pouvons notamment agir sur la qualité micro­biologique ou particulaire de l’air au bloc opératoire, sur la qualité microbiologique de l’eau (chaude ou froide) utilisée dans de multiples usages à l’hôpital et sur le choix des techniques et procédures de désinfection des dispositifs médicaux et des surfaces hospitalières. Pour ce qui est de la qualité des soins les procédures qui décrivent comment réduire le risque infectieux associé aux soins sont elles-mêmes des démarches écoresponsables. Cet aspect de nos missions est certainement à mettre en avant pour inciter les professionnels à respecter les consignes d’hygiène. Quant à la vaccination dont nous devons faire la promotion, elle est le premier des soins écoresponsables puisqu’elle permet de limiter les besoins en soins. Nous décrivons nos interventions et décisions dans ces différents domaines pour que l’hygiène hospitalière réoriente ses missions ou l’interprétation de ses missions vers cette notion d’écoresponsabilité qui nous est chère.
Differentiating between the forms of Mycobacterium tuberculosis disease through immune markers: a translational study through treatment of active and latent tuberculosis infections. Investigating Toll-like receptors and their function, and comparison of two interferon-gamma-receptor assays
Creators: name: SABINE LILAMANI DE SILVA
Publisher: name: Monash University
Year: 2019
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 110707 Innate Immunity
subject: FOS: Clinical medicine

description: This thesis examined immune markers in patients with active and dormant tuberculosis infections. Investigations were undertaken to help better understand the differences in these immune markers in patients whilst they received antibiotic therapy for their infections. It is hoped that these changes can be used as part of clinical tests in the future.
Images from the Minster Church of St Mary, Stow in Lindsey
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: St Mary's, Stow-in-Lindsey is one of the few surviving Anglo-Saxon Minster churches, and is chiefly remarkable for its impressive size compared with other surviving Anglo-Saxon buildings. It gives an idea of what must have been lost when the Normans rebuilt so much after the Conquest. It can be seen from afar, surrounded by its small village, in the largely flat countryside north-west of Lincoln. It rises straight up, without any later additions of aisles or clerestories. There have been some Norman and later modifications, but its size must be almost exactly the same as in about 1050. The nave and chancel were rebuilt in Norman times, and the latter is a fine example of that period, but the surviving Anglo-Saxon features are unique, comprising the crossing with its four high arches, as well as the transepts. There were two periods of the Anglo-Saxon building, as it is recorded that a Bishop Eadnoth rebuilt the church. As there were two bishops of that name, the rebuilding took place either between c. 1004 and 1016 or between c. 1034 and 1050. The lower parts of the walls appear to be of the earlier period, and show signs of fire. The crossing arches are about 14 feet wide, but 30 feet in height, and apart from Norton in County Durham, Stow has the only surviving true Anglo Saxon crossing, all four arches being of the same height. They are unmistakably Anglo-Saxon, and similar although lower arches can be seen at Wittering near Peterborough and St Benetâ€™s in Cambridge. The masonry of the transepts is Anglo-Saxon, and includes a complete window and a doorway, and traces of two further windows. The crossing at Stow was reinforced by the insertion of pointed gothic arches in about the 14th century, possibly to take the added weight of the new crossing tower which might have been previously of wood. The roofs were lowered at the same time, but in the 19th century a major restoration took place, raising the roofs again and otherwise taking the building back closer to its Anglo-Saxon and Norman appearance. A visit to the Minster Church of St Mary, Stow in Lindsey remains a breathtaking experience a thousand years after its construction.
title: Development and efficacy testing of a computer-based counseling for patients with back pain
title: Entwicklung und Wirksamkeitsprüfung einer computerbasierten Beratung für Patienten mit Rückenschmerzen – eine randomisierte kontrollierte Studie
Creators: name: Feuerhahn, Lena Marie
Publisher: name: Philipps-Universität Marburg
Year: 2012
Subjects: Back pain
Rückenschmerz
Medizin, Gesundheit

description: Rückenschmerz ist als eine der
      häufigsten Krankheiten besonders in den Industrieländern
      stark verbreitet. Häufig chronifizieren die Schmerzen.
      Aufgrund der großen Bedeutung von Aufklärung und Anleitung zu
      Selbstmanagement in der Behandlung von Rückenschmerzen, sind
      die Entwicklung effektiver präventiver Maßnahmen und
      Maßnahmen zur Beratungsunterstützung wichtig. In
      verschiedenen Studien konnte bereits die Wirkung der
      Patientenaufklärung nachgewiesen werden. Unter anderem durch
      die Broschüre „Das Rücken-Buch“ konnten Veränderung der
      Einstellung und Überzeugung von Rückenschmerzpatienten
      gezeigt werden. Im Hinblick auf die Möglichkeiten der
      Wissensvermittlung und der Aufklärung von Patienten, wurden
      Konzepte von computerbasierter Beratung bereits in
      erschiedenen Studien untersucht. Die dadurch gebotenen
      Möglichkeiten, der Interaktivität mit dem System und des
      Einsatzes von Medien wie Ton, Videos, Fotos und Graphiken,
      hat sich als praktikabel, kostengünstig und von den Patienten
      als akzeptiert herausgestellt.
description: Back Pain is one of the most
      frequent complaints and especially in the industrialized
      countries widespread. Often the pain becomes chronic. Due to
      the high relevance of education and instruction to self
      management, the development of effective measures for
      prevention and consulting advises is very important.
      Different studies already showed the effect of self
      management education. Among others the pamphlet “The Back
      Book” could show a shifting of attitude and beliefs of back
      pain patients. Regarding the possibilities of instructing and
      informing patients, concepts of cumputerized counselling have
      been investigated in some studies. The potential of
      multimedia such as sound, videos, photos and graphics, and an
      interactive system that interferes with the user, has proven
      to be feasible, low priced, and accepted by the
      users.
Advantage of probabilistic non-Gaussian operations in the distillation of single mode squeezed vacuum state
Creators: name: Kumar, Chandan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider the distillation of squeezing in single mode squeezed vacuum state using three different probabilistic non-Gaussian operations: photon subtraction (PS), photon addition (PA) and photon catalysis (PC). To accomplish this, we consider a practical model to implement these non-Gaussian operations and derive the Wigner characteristic function of the resulting non-Gaussian states. Our result shows that while PS and PC operations can distill squeezing, PA operations cannot. Furthermore, we delve into the success probabilities associated with these non-Gaussian operations and identify optimal parameters for the distillation of squeezing. Our current analysis holds significant relevance for experimental endeavors concerned with squeezing distillation.
description: 8 pages, 7 figures; Comments are most welcome!
Neutrophils in colitis: the role of the gut microbiota
Creators: name: SJ SIJIE SHEN
Publisher: name: Monash University
Year: 2019
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Patients with ulcerative colitis experience debilitating symptoms such as severe weight loss, bloody diarrhea and constant fatigue. Although abnormal immune cell infiltration is thought to be a contributing factor, the underlying mechanism remains unknown. Recent evidence suggests that the gut microbiota play important roles in the balance between health and disease. Indeed, my research findings demonstrate that removal of invariant natural killer T cells change the gut microbiota to one that attenuates colitis development. In contrast, a fibre-deficient diet enriches for bacteria in the gut that worsen disease. Therefore, modulation of gut bacteria is a novel therapeutic strategy for colitis.
Images from the Minster Church of St Mary, Stow in Lindsey
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: St Mary's, Stow-in-Lindsey is one of the few surviving Anglo-Saxon Minster churches, and is chiefly remarkable for its impressive size compared with other surviving Anglo-Saxon buildings. It gives an idea of what must have been lost when the Normans rebuilt so much after the Conquest. It can be seen from afar, surrounded by its small village, in the largely flat countryside north-west of Lincoln. It rises straight up, without any later additions of aisles or clerestories. There have been some Norman and later modifications, but its size must be almost exactly the same as in about 1050. The nave and chancel were rebuilt in Norman times, and the latter is a fine example of that period, but the surviving Anglo-Saxon features are unique, comprising the crossing with its four high arches, as well as the transepts. There were two periods of the Anglo-Saxon building, as it is recorded that a Bishop Eadnoth rebuilt the church. As there were two bishops of that name, the rebuilding took place either between c. 1004 and 1016 or between c. 1034 and 1050. The lower parts of the walls appear to be of the earlier period, and show signs of fire. The crossing arches are about 14 feet wide, but 30 feet in height, and apart from Norton in County Durham, Stow has the only surviving true Anglo Saxon crossing, all four arches being of the same height. They are unmistakably Anglo-Saxon, and similar although lower arches can be seen at Wittering near Peterborough and St Benetâ€™s in Cambridge. The masonry of the transepts is Anglo-Saxon, and includes a complete window and a doorway, and traces of two further windows. The crossing at Stow was reinforced by the insertion of pointed gothic arches in about the 14th century, possibly to take the added weight of the new crossing tower which might have been previously of wood. The roofs were lowered at the same time, but in the 19th century a major restoration took place, raising the roofs again and otherwise taking the building back closer to its Anglo-Saxon and Norman appearance. A visit to the Minster Church of St Mary, Stow in Lindsey remains a breathtaking experience a thousand years after its construction.
Reconstruction of the Sutton Hoo ship burial
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photograph of the reconstruction of the ship burial chamber, from the visitor centre, at Sutton Hoo near Woodbridge, Suffolk. Many of the artefacts near the upper body of the burial which have been reproduced for the exhibition are visible including the Sutton Hoo helmet and a gaming-board with a game set-up ready to play.
Reducing Energy Bloat in Large Model Training
Creators: name: Chung, Jae-Won
name: Gu, Yile
name: Jang, Insu
name: Meng, Luoxi
name: Bansal, Nikhil
name: Chowdhury, Mosharaf
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Training large AI models on numerous GPUs consumes a massive amount of energy, making power delivery one of the largest limiting factors in building and operating datacenters for AI workloads. However, we observe that not all energy consumed during training directly contributes to end-to-end throughput; a significant portion can be removed without slowing down training. We call this portion energy bloat.
 In this work, we identify two independent sources of energy bloat in large model training and propose Perseus, a training system that mitigates both. To do this, Perseus obtains the time--energy tradeoff frontier of a large model training job using an efficient graph cut-based algorithm, and schedules computation energy consumption across time to reduce both types of energy bloat. Evaluation on large models, including GPT-3 and Bloom, shows that Perseus reduces the energy consumption of large model training by up to 30% without any throughput loss or hardware modification.
description: SOSP 24 | Open-source part of Zeus at https://ml.energy/zeus/research_overview/perseus/
Global analysis of CP-violation in atoms, molecules and role of medium-heavy systems
Creators: name: Gaul, Konstantin
name: Berger, Robert
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Detection of parity (P) and time-reversal (T) symmetry-odd electric dipole moments (EDMs) within currently achievable resolution would evidence physics beyond the Standard Model of particle physics. Via the CPT-theorem, which includes charge conjugation (C), such low-energy searches complement high-energy physics experiments that probe CP-violation up to the TeV scale. Heavy-elemental atoms and molecules are considered to be among the most promising candidates for a first direct detection of P,T-violation due to enhancement effects that increase steeply with increasing nuclear charge number $Z$. However, different P,T-odd sources on the subatomic level can contribute to molecular or atomic EDMs, which are target of measurements, and this complicates obtaining rigorous bounds on P,T-violation on a fundamental level. Consequently, several experiments of complementary sensitivity to these individual P,T-odd sources are required for this purpose. Herein, a simply-applicable qualitative model is developed for global analysis of the P,T-odd parameter space from an electronic-structure theory perspective. Rules of thumb are derived for the choice of atoms and molecules in terms of their angular momenta and nuclear charge number. Contrary to naive expectations from $Z$-scaling laws, it is demonstrated that medium-heavy molecules with $Z\leq54$ can be of great value to tighten global bounds on P,T-violating parameters, in particular, if the number of complementary experiments increases. The model is confirmed by explicit density functional theory calculations of all relevant P,T-odd electronic structure parameters in systems that were used in past experiments or are of current interest for future experiments, respectively: the atoms Xe, Cs, Yb, Hg, Tl, Ra, Fr and the molecules CaOH, SrOH, YO, CdH, BaF, YbF, YbOH, HfF$^+$, WC, TlF, PbO, RaF, ThO, ThF$^+$ and PaF$^{3+}$.
description: 27 pages, 5 figures, 14 tables, supplementary material; correction of Wdm DFT values for TlF, minor corrections in table VI, improved MQM values in table X, references and acknowledgements updated, minor corrections on the text
Wearable Devices for the Measurement of Osteogenic Activity: May the Force be With You
Creators: name: LACHLAN BRIAN MCMILLAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 110399 Clinical Sciences not elsewhere classified
subject: Medicine

description: This thesis examines how day-to-day physical activity can influence the health of our bones throughout ageing. This thesis has used a range of wearable devices and analysis techniques to calculate a range of metrics relevant to our daily activity levels, from the intensity of activity, to the impact forces experienced by the body. This thesis culminates in a now patented prototype wearable device able to calculate the forces experienced by bones, during various forms of physical activity and exercise.
Fractional factors and component factors in graphs with isolated toughness smaller than 1
Creators: name: Wolf, Isaak H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Let $G$ be a simple graph and let $n,m$ be two integers with $0
description: 14 pages
Reconstruction of the Sutton Hoo ship burial
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photograph of the reconstruction of the ship burial chamber, from the visitor centre, at Sutton Hoo near Woodbridge, Suffolk. Many of the artefacts near the upper body of the burial which have been reproduced for the exhibition are visible including the Sutton Hoo helmet and a gaming-board with a game set-up ready to play.
Blood pressure, Aortic Stiffness, Haemodynamics, and Brain Health in Type 2 Diabetes Mellitus
Creators: name: CHRISTOPHER CHARLES KARAYIANNIS
Publisher: name: Monash University
Year: 2019
Subjects: subject: Neuroscience
subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: Medicine

description: Type 2 diabetes (T2D) is associated with dementia. High blood pressure (BP) and stiffening of blood vessels might explain this association. I examined the role of BP and blood vessel stiffness on brain health in T2D in two separate samples. I found that T2D was associated with higher BP during sleep and this affected the cognition of those with T2D. I also found that in those with T2D, high BP and blood vessel stiffness were associated with subtle damage to the brain. These results suggest that BP and blood vessel health might be important in T2D-related dementia
Saxon Era - Learning Resources (Corhampton Saxon Church)
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: In 2010, the Friends of Corhampton Saxon Church and Meonstoke Infant School organised a Saxon learning day for the eighty pupils at the school. This was followed by the 1st Saxon Festival in the Meon Valley Since the 11th Century. We were supported by Droxford Junior School, Saxon era historical and cultural experts and enthusiasts from Winchester City Council Museum Services, Winchester Cathedral education department, Winchester College, Hampshire Archives & Local Studies and Hampshire Wardrobe. In addition local farmers, Gill & Bruce Horn, on whose land a Saxon cemetery and village were discovered in the 1980s shared artefacts from the excavation. Details of the learning resources used at these events are attached to this submission. Additional information about the two events is included in additional submissions. Meonstoke School and Corhampton Saxon Church are 15 miles from Wintonceastre (Winchester), the capital of the Saxon kingdom of Wessex and of Saxon England. They are located on opposite banks of the River Meon which runs from East Meon on the South Downs, through the Meon Valley to the Solent at Titchfield Haven. The River Meon formed the boundary between the West Saxons (Wessex) and the South Saxons (Sussex). It gave its name, which derives from a Celtic word meaning 'swift one', to the Meonwara (or MeonsÃ¦te) the people of Jutish origin who colonised the East bank of the River in the 5th & 6th century. The Church, which was built in 1020, when Cnute was King of Wessex and England, has been a place of Christian worship for over 1000 years. Excavations in the 20th century led to the discovery close to the Church of Saxon/Jutish cemeteries and a Saxon village. The Friends of Corhampton Church, again working with local schools and Saxon heritage organisations followed the school learning day with the first Saxon festival for over 1000 years, held in July 2010 (see separate submission). Additional information about Corhampton Saxon Church and the 1000 year old Yew Tree in the graveyard can be found in a separate submission and at www.bridgechurches.org.uk. You can also sign-up at this website to become a 'Friend' to ensure the future of this Saxon icon and to support & participate in future festivals, education and exploratory activities.
Antibiotiques et résistances : épisode 1, les bêtalactamines
Creators: name: Jean-Winoc Decousser
name: Pozzetto, Bruno
name: Romano-Bertrand, Sara
Publisher: name: Health & Co
Year: 2025
Subjects: Antibiotiques
Résistance aux antibiotiques
Bêta-lactamase
Céphalosporines

description: De même que la vaccinologie, l’antibiothérapie a bouleversé la prise en charge des maladies infectieuses bactériennes. Pourtant, l’apparition de résistances acquises remet en cause les avancées obtenues. Nous décrivons les principales molécules disponibles en France, leurs utilisations et les principaux taux de résistance associés. Les bêtalactamines sont les antibiotiques les plus utilisés en ville et à l’hôpital en raison de leur diversité, de la variété des spectres d’activité et de leur très bonne tolérance liée à une cible d’action strictement bactérienne. Les pénicillines constituent un premier groupe de bêtalactamines comportant la pénicilline historique et ses dérivés, ainsi que d’autres molécules très utilisées comme l’amoxicilline et la pipéracilline. Les céphalosporines constituent le second groupe avec cinq générations de molécules présentant des propriétés différentes, toutes utilisées. D’autres composants ont une vocation plus hospitalière : les carbapénèmes, résistant à la quasi-totalité des bêtalactamases les plus fréquentes, les monobactames et le céfidérocol. Pour faire face aux résistances acquises par production d’enzymes les hydrolysant, des inhibiteurs enzymatiques sont associés à ces molécules. L’émergence récente de souches bactériennes résistantes à toutes les bêtalactamines par production de carbapénémases pose un problème de santé publique majeur, imparfaitement corrigé par de nouvelles molécules ou associations. Cette course sans fin entre émergence de la résistance aux antibiotiques et commercialisation de nouvelles molécules met en exergue l’importance de la prévention des infections bactériennes par la vaccination et l’hygiène, mais aussi celle de la promotion de l’épargne antibiotique en combattant notamment les utilisations abusives ou infondées.
Spatiotemporal genomics of human medulloblastoma at single-nucleus resolution
Creators: name: 韩洞明(Dongming Han)
Publisher: name: CNGB
Year: 2023
Subjects: Genome sequencing and assembly
Monoisolate
Medical

description: Whereas evidences of single-cell studies have suggested the cellular diversity of medulloblastoma, the most common malignant brain tumor in childhood, the understanding of spatial status for specific cell populations remains rudimentary. Herein, we comprehensively analyze single-nucleus RNA expression, chromatin accessibility and spatial transcriptomic profiling from 51 human medulloblastomas spanning four molecular subgroups, complemented with the bulk whole genome and RNA sequencing data across 334 human samples. We interrogated the malignant compositions including the progenitor, cycling and more differentiated subpopulations, gene signatures strongly correlating to clinical outcomes. Further, we spatiotemporally described the developmental trajectories from initial root cells to mature stations through medulloblastoma transitional progenitors, which presented across all the subgroups. To better implicate the spatial architecture of local environment, harmony alignment revealed that niche-dependent cell distributions were recapitulated by arrangements of the identified lineage states and inflammatory or fibrotic adaptions. Through regionally deciphering the copy number variations and transcriptional programs at single-cell resolution, we in-depth characterized the cohesive subclones according to tumor individuals, demonstrating that medulloblastoma resided with enormous genetic heterogeneity. Altogether, our findings gather insights into transcriptome and epigenome of medulloblastoma progenitor subpopulations predisposed to transition along the evolutionary continuum, providing a spatiotemporal perspective to mechanistic and therapeutic advances of pediatric neuro-oncological disorder.
Disc Novae: Thermodynamics of Gas Assisted Binary Black Hole Formation in AGN Discs
Creators: name: Whitehead, Henry
name: Rowan, Connar
name: Boekholt, Tjarda
name: Kocsis, Bence
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the thermodynamics of close encounters between stellar mass black holes (BHs) in the gaseous discs of active galactic nuclei (AGN), during which binary black holes (BBHs) may form. We consider a suite of 2D viscous hydrodynamical simulations within a shearing box prescription using the Eulerian grid code Athena++. We study formation scenarios where the fluid is either an isothermal gas or an adiabatic mixture of gas and radiation in local thermal equilibrium. We include the effects of viscous and shock heating, as well as optically thick cooling. We co-evolve the embedded BHs with the gas, keeping track of the energetic dissipation and torquing of the BBH by gas and inertial forces. We find that compared to the isothermal case, the minidiscs formed around each BH are significantly hotter and more diffuse, though BBH formation is still efficient. We observe massive blast waves arising from collisions between the radiative minidiscs during both the initial close encounter, and subsequent periapsis periods for successfully bound BBHs. These "disc novae" have a profound effect, depleting the BBH Hill sphere of gas and injecting energy into the surrounding medium. In analysing the thermal emission from these events, we observe periodic peaks in local luminosity associated with close encounters/periapses, with emission peaking in the optical/near-IR. In the AGN outskirts, these outbursts can reach 4% of the AGN luminosity in the IR band, with flares rising over 0.5-1year. Collisions in different disc regions, or when treated in 3D with magnetism, may produce more prominent flares.
description: 16 pages, 13 figures, accepted for publication in MNRAS
The Association Between Epicardial Adipose Tissue and Coronary Plaque Characteristics: Insights from Computed Tomography Coronary Angiography
Creators: name: NITESH NERLEKAR
Publisher: name: Monash University
Year: 2019
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: This thesis investigates the measurement and relationship of epicardial fat, the fat layer around the heart and heart arteries and its effect on the development of vulnerable plaques that can result in heart attacks, irrespective of patient weight. It identifies the appropriate method of measurement and associations with heart dysfunction and suggests that this may be a novel target for future treatment.
Improving care and outcomes after stroke: a focus on hospitals and community-based interventions
Creators: name: THARSHANAH THAYABARANATHAN
Publisher: name: Monash University
Year: 2020
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Neuroscience

description: This thesis highlights the impact of stroke around the world, and potential strategies to identify and reduce evidence-to-practice gaps in stroke care. The evidence from this thesis could also help inform policy and practice decisions on how to better support survivors of stroke with anxiety and depression in the early period following stroke, and strategies to reduce these consequences when in the community.
Musculoskeletal and vascular ageing: Points of intersection
Creators: name: ALEXANDER JOSEPH RODRIGUEZ
Publisher: name: Monash University
Year: 2019
Subjects: Medicine

description: This thesis investigates clinical relationships between diseases frequently co-existing in older age. It identifies individuals that with low muscle and bone mass frequently have significant amounts of cardiovascular disease, particularly diseases which affect blood vessels. This thesis does not support the use of vitamin D to treat these conditions and further, it demonstrates that very high amounts of calcium in the diet may be detrimental to cardiovascular health.
title: Medizinische Begutachtung digitaler Gesundheitsanwendungen im Projekt „Trusted Health Apps“. Bewertungsprojekt: Kardiologie. Anwendung: FibriCheck
Creators: name: Thiele, Christian
Publisher: name: Bertelsmann Stiftung
publisherIdentifier: https://ror.org/01wj9hk44
publisherIdentifierScheme: ROR
Year: 2025
Subjects: Digitale Gesundheitsanwendung
Kardiologie
Vorhofflimmern

description: Unsere medizinische Bewertung digitaler Gesundheitsanwendungen (DiGA) zeigt, dass die medizinische Qualität und Unterschiede in ihrer Evidenzlage systematisch und transparent dargestellt werden können. Dies ist ein entscheidender Schritt, um Patientinnen und Patienten sowie der Ärzteschaft und anderen Stakeholdern Orientierung zu bieten.

In diesem Bericht werden die Bewertungsergebnisse der Anwendung „FibriCheck“ dargestellt.
Immune biomarkers and infections in kidney transplant recipients
Creators: name: CLAIRE DENDLE
Publisher: name: Monash University
Year: 2019
Subjects: subject: 110708 Transplantation Immunology
subject: FOS: Clinical medicine
subject: 110312 Nephrology and Urology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Immunology

description: The aim of this thesis was to find immune biomarkers that can predict the development of severe infection in kidney transplant recipients. We enrolled 168 clinically stable kidney transplant recipients, undertook baseline immune testing and followed patients prospectively for two years. Thirty-five percent of patients developed an infection. Several biomarkers and a composite score of biomarkers and clinical characteristics could successfully discriminate between patients at very high risk of developing infection and those at a lower risk. These biomarkers can assist clinicians to make decisions about infection prevention and inform future studies aimed at finding safe ways to reduce immunosuppression.
Saxon Era - Learning Resources (Corhampton Saxon Church)
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: In 2010, the Friends of Corhampton Saxon Church and Meonstoke Infant School organised a Saxon learning day for the eighty pupils at the school. This was followed by the 1st Saxon Festival in the Meon Valley Since the 11th Century. We were supported by Droxford Junior School, Saxon era historical and cultural experts and enthusiasts from Winchester City Council Museum Services, Winchester Cathedral education department, Winchester College, Hampshire Archives & Local Studies and Hampshire Wardrobe. In addition local farmers, Gill & Bruce Horn, on whose land a Saxon cemetery and village were discovered in the 1980s shared artefacts from the excavation. Details of the learning resources used at these events are attached to this submission. Additional information about the two events is included in additional submissions. Meonstoke School and Corhampton Saxon Church are 15 miles from Wintonceastre (Winchester), the capital of the Saxon kingdom of Wessex and of Saxon England. They are located on opposite banks of the River Meon which runs from East Meon on the South Downs, through the Meon Valley to the Solent at Titchfield Haven. The River Meon formed the boundary between the West Saxons (Wessex) and the South Saxons (Sussex). It gave its name, which derives from a Celtic word meaning 'swift one', to the Meonwara (or MeonsÃ¦te) the people of Jutish origin who colonised the East bank of the River in the 5th & 6th century. The Church, which was built in 1020, when Cnute was King of Wessex and England, has been a place of Christian worship for over 1000 years. Excavations in the 20th century led to the discovery close to the Church of Saxon/Jutish cemeteries and a Saxon village. The Friends of Corhampton Church, again working with local schools and Saxon heritage organisations followed the school learning day with the first Saxon festival for over 1000 years, held in July 2010 (see separate submission). Additional information about Corhampton Saxon Church and the 1000 year old Yew Tree in the graveyard can be found in a separate submission and at www.bridgechurches.org.uk. You can also sign-up at this website to become a 'Friend' to ensure the future of this Saxon icon and to support & participate in future festivals, education and exploratory activities.
title: From Polycarbonyls to Poly(phenylene)s - Applications of the Cobalt-Catalyzed Diels-Alder Reaction
title: Von Polycarbonylen zu Poly(phenylen)en - Anwendungsgebiete der Cobalt-katalysierten Diels-Alder-Reaktion
Creators: name: Kuttner, Julian
Publisher: name: Philipps-Universität Marburg
Year: 2015
Subjects: Surface-assisted Synthesis
Katalyse
Chemie
Cobalt
Polycarbonyls
Suzuki Polycondensation
Diels-Alder

description: Die Cobalt-katalysierte Diels-Alder
      Reaktion wurde angewendet, um regioselektiv 1,4-Cyclohexadien
      Derivate zu erzeugen, die als Ausgangsmaterialien in der
      Synthese von Polycarbonylen und Poly(phenylen)en eingesetzt
      wurden.
description: The cobalt-catalyzed Diels-Alder
      reaction was applied to synthesize 1,4-cyclohexadiene
      derivatives regioselectively. These served as starting
      materials for the subsequent synthesis of polycarbonyls and
      poly(phenylene)s.
The molecular characterisation of peripheral T cell lymphomas
Creators: name: GREGORY JOHN HAPGOOD
Publisher: name: Monash University
Year: 2019
Subjects: Medicine

description: Peripheral T cell lymphomas (PTCL) are aggressive lymphomas with poor outcomes with current treatments. Previous research has been hampered by the use of whole lymph node biopsies which represent a mixture of malignant and non-malignant cells, thus partly obscuring the malignant cells. Here, we used an innovative methodology to isolate and purify the malignant cells, then confirmed the malignant nature of each sample before performing RNA-sequencing to identify critical gene signatures in malignant cells. We demonstrated important signatures regarding the cell-of-origin and a molecular switch for malignant transformation of the two commonest subtypes of PTCLs.
Reconstruction of the Sutton Hoo ship burial
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photograph of the reconstruction of the ship burial chamber, from the visitor centre, at Sutton Hoo near Woodbridge, Suffolk. Showing the body of the burial including many of the artefacts which have been reproduced for the exhibition including the Sutton Hoo helmet.
Project Summary: Facilitating Farmer Economic Understanding of Alternative Land Uses
Creators: name: Benny, Tony
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: This article summarises the results of a Rural Professionals Fund project that aimed to investigate the challenges faced by landowners when they seek to diversify via land use change. All text in this article is licensed for re-use under Creative Commons Attribution 4.0 International (CC BY 4.0).
Risk prediction and Management of Paracetamol Overdose
Creators: name: ANSELM YAO-MING WONG
Publisher: name: Monash University
Year: 2018
Subjects: subject: 110307 Gastroenterology and Hepatology
subject: FOS: Clinical medicine
subject: 111506 Toxicology (incl. Clinical Toxicology)
subject: 111502 Clinical Pharmacology and Therapeutics

description: Paracetamol is the one of the most common drugs taken in overdose and hundreds of thousands of people are treated worldwide per annum. This affects all ages, the majority of these involve young females who have the whole of their lives ahead of them. My PhD has helped to evaluate risk prediction tools, decrease the severe adverse effects that can be associated with the antidote (acetylcysteine) and investigate shorter treatment regimens for paracetamol overdose. This could lead to shorter stays in hospital freeing up beds and resources in an already overcrowded health system.
Reconstruction of the Sutton Hoo ship burial
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photograph of the reconstruction of the ship burial chamber, from the visitor centre, at Sutton Hoo near Woodbridge, Suffolk. Showing the body of the burial including many of the artefacts which have been reproduced for the exhibition including the Sutton Hoo helmet.
Antigen-specific T cells in Autoimmune Glomerulonephritis
Creators: name: MEGAN  HUYNH
Publisher: name: Monash University
Year: 2018
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Specialised immune cells called T cells are known to mistakenly recognise a protein in the body as foreign and cause disease. This thesis underscores the contribution of these cells in autoimmune kidney disease and suggests new treatments that specifically act on the T cells, such as by blocking their activity, or activating other immune cells with regulatory function that can inhibit the T cells. These techniques act in a targeted manner and can improve on current treatments that suppress the entire immune system.
What is the Magnus Expansion?
Creators: name: Ebrahimi-Fard, Kurusch
name: Mencattini, Igor
name: Quesney, Alexandre
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mathematical Physics (math-ph)
subject: Rings and Algebras (math.RA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 16S30, 16T30, 17A30

description: The Magnus expansion, introduced by Wilhelm Magnus in 1954, is an infinite Lie series employed to express solutions for first-order homogeneous linear differential equations involving a linear operator. Since its discovery it has evolved into a pivotal tool used across diverse disciplines, including physics, chemistry, and engineering. Over the past 25 years, the Magnus expansion has undergone significant mathematical developments which revealed an intricate interplay between algebra, combinatorics, and geometry. By emphasizing a modern perspectives based on the use of pre- and post-Lie algebras, we discuss the Magnus expansion from the viewpoint of the notion of crossed morphism.
description: 33 pages, final version
Human amnion epithelial cells, a novel treatment for hepatic and gastrointestinal diseases
Creators: name: NATHAN TIMOTHY KUK
Publisher: name: Monash University
Year: 2018
Subjects: Stem Cells
Medicine

description: "This thesis examines the efficacy of a pluripotent stem cell (human amnion epithelial cell) extracted from the amnion layer of the placenta as a novel therapy for non-alcoholic fatty liver disease (NAFLD) and inflammatory bowel disease (IBD). It identifies the disease modulating effects and highlights the anti-inflammatory and anti-fibrotic properties of hAECs and establishes a foundation for future research.
Wigner 6j symbols with gluon lines: completing the set of 6j symbols required for color decomposition
Creators: name: Keppeler, Stefan
name: Plätzer, Simon
name: Sjodahl, Malin
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We construct a set of Wigner 6j symbols with gluon lines (adjoint representations) in closed form, expressed in terms of similar 6j symbols with quark lines (fundamental representations). Together with Wigner 6j symbols with quark lines, this gives a set of 6j symbols sufficient for treating QCD color structure for any number of external particles, in or beyond perturbation theory. This facilitates a complete treatment of QCD color structure in terms of orthogonal multiplet bases, without the need of ever explicitly constructing the corresponding bases. We thereby open up for a completely representation theory based treatment of SU(N) color structure, with the potential of significantly speeding up the color structure treatment.
description: 30 pages, 1 figure
Improving outcome measures for antiemetic efficacy trials in adult emergency department patients with nausea.
Creators: name: ROBERT ARTHUR MEEK
Publisher: name: Monash University
Year: 2019
Subjects: Medicine

description: Nausea is a common problem for emergency department (ED) patients. The treatment objective is clinically significant symptom improvement during ED care. The traditional primary outcome measure is comparison of mean visual analog scale (VAS) rating change between groups. Interpretation of results is difficult, because this is an indirect and imprecise measure of symptom improvement. This research identified and tested a novel method using VAS change to identify improved patients. This directly aligns the primary outcome measure with the primary treatment objective. Between-group comparisons of symptom improvement rates ensure study results are presented in a clinically meaningful, easily understandable way.
Human amnion epithelial cells, a potential therapy for chronic liver injury
Creators: name: MAJID GHARAMA S ALHOMRANI
Publisher: name: Monash University
Year: 2018
Subjects: Medicine

description: The incidence of the population being affected by chronic liver disease is being increased disproportionately, with the expenses of treatment being enormous. With the only effective treatment for end-stage liver disease being liver transplantation, recent growing evidence indicates the potential of cell therapy as a treatment option for different diseases, including liver injury. Human Amniotic Epithelial Cells (hAECs) are isolated from the amnion of the placenta in sufficient numbers for clinical use and bear many characteristics of traditional stem cells. The work performed in the thesis adds to the evidence that hAECs may be used as a potential therapy for liver injury.