cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(3734) Edward Joseph Jordan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Frequency-agile dual-comb spectroscopy
Creators: name: Millot, Guy
name: Pitois, Stéphane
name: Yan, Ming
name: Hovannysyan, Tatevik
name: Bendahmane, Abdelkrim
name: Hänsch, Theodor W.
name: Picqué, Nathalie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We propose a new approach to near-infrared molecular spectroscopy, harnessing advanced concepts of optical telecommunications and supercontinuum photonics. We generate, without mode-locked lasers, two frequency combs of slightly different repetition frequencies and moderate, but rapidly tunable, spectral span. The output of a frequency-agile continuous wave laser is split and sent into two electro-optic intensity modulators. Flat-top low-noise frequency combs are produced by wave-breaking in a nonlinear optical fiber of normal dispersion. With a dual-comb spectrometer, we record Doppler-limited spectra spanning 60 GHz within 13 microseconds and 80-kHz refresh rate, at a tuning speed of 10 nm.s^(-1). The sensitivity for weak absorption is enhanced by a long gas-filled hollow-core fiber.
description: 7 pages, 5 figures
Additional file 8 of Identification and distribution of gene clusters required for synthesis of sphingolipid metabolism inhibitors in diverse species of the filamentous fungus Fusarium
Creators: name: Hye-Seon Kim
name: Lohmar, Jessica M.
name: Busman, Mark
name: Brown, Daren W.
name: Naumann, Todd A.
name: Divon, Hege H.
name: Uhlig, Silvio
name: Proctor, Robert H.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 8. Deletion analysis of the SAM5 PKS gene, AOD1, in F. babinda NRRL 25539 and F. tricinctum strain NRRL 25481.
A Robust Spectral Algorithm for Overcomplete Tensor Decomposition
Creators: name: Hopkins, Samuel B.
name: Schramm, Tselil
name: Shi, Jonathan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Data Structures and Algorithms (cs.DS)
subject: Numerical Analysis (math.NA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: G.3; I.2.6; G.1.3; F.2.1

description: We give a spectral algorithm for decomposing overcomplete order-4 tensors, so long as their components satisfy an algebraic non-degeneracy condition that holds for nearly all (all but an algebraic set of measure $0$) tensors over $(\mathbb{R}^d)^{\otimes 4}$ with rank $n \le d^2$. Our algorithm is robust to adversarial perturbations of bounded spectral norm. Our algorithm is inspired by one which uses the sum-of-squares semidefinite programming hierarchy (Ma, Shi, and Steurer STOC'16, arXiv:1610.01980), and we achieve comparable robustness and overcompleteness guarantees under similar algebraic assumptions. However, our algorithm avoids semidefinite programming and may be implemented as a series of basic linear-algebraic operations. We consequently obtain a much faster running time than semidefinite programming methods: our algorithm runs in time $\tilde O(n^2d^3) \le \tilde O(d^7)$, which is subquadratic in the input size $d^4$ (where we have suppressed factors related to the condition number of the input tensor).
description: 60 pages, 4 figures, ACM Annual Workshop on Computational Learning Theory 2019
Weight loss, lifestyle intervention and metformin affect longitudinal relationship of insulin secretion and sensitivity: Supplemental material
Creators: name: Vazquez Arreola, Elsa
name: L. Hanson, Robert
name: C. Knowler, William
Publisher: name: figshare
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Pathogenesis

description: Supplemental material for paper
(3735) Honor Mary Stanhope Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The Sensitivity and Vulnerability of the Pacific Northwest (USA) to Climate Variability and Change: A Human Dimensions Perspective
Creators: name: Miles, Edward L.
name: Hamlet, Alan
name: Snover, Amy
name: Callahan, Bridget
name: Fluharty, David
Publisher: name: University of Washington Climate Impacts Group
Year: 1998

description: Paper prepared for the IHDP/GECHS Workshop on water and Human Security in Southeast Asia and Oceania, Canberra, Australia, Australian National University, 16-18 November, 1998. Following the paper on patterns of climate variability in the Pacific Northwest (PNW) (USA) by Nathan Mantua; and the paper analyzing the impacts of climate variability on patterns of reservoir operations by Alan Hamlet, this paper completes the triptych on the integrated assessment of the impacts of climate variability and change in the region. The paper answers three questions from a human dimensions perspective: I. How sensitive is the PNW to climate variability? 2. How adaptable is the PNW to climate variability and change? 3. How vulnerable is the PNW to climate variability and change?
Effects of Coupled Dark Energy on the Milky Way and its Satellites
Creators: name: Penzo, Camilla
name: Macciò, Andrea V.
name: Baldi, Marco
name: Casarini, Luciano
name: Oñorbe, Jose
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first numerical simulations in coupled dark energy cosmologies with high enough resolution to investigate the effects of the coupling on galactic and sub-galactic scales. We choose two constant couplings and a time-varying coupling function and we run simulations of three Milky-Way-size halos ($\sim$10$^{12}$M$_{\odot}$), a lower mass halo (6$\times$10$^{11}$M$_{\odot}$) and a dwarf galaxy halo (5$\times$10$^{9}$M$_{\odot}$). We resolve each halo with several millions dark matter particles. On all scales the coupling causes lower halo concentrations and a reduced number of substructures with respect to LCDM. We show that the reduced concentrations are not due to different formation times, but they are related to the extra terms that appear in the equations describing the gravitational dynamics. On the scale of the Milky Way satellites, we show that the lower concentrations can help in reconciling observed and simulated rotation curves, but the coupling values necessary to have a significant difference from LCDM are outside the current observational constraints. On the other hand, if other modifications to the standard model allowing a higher coupling (e.g. massive neutrinos) are considered, coupled dark energy can become an interesting scenario to alleviate the small-scale issues of the LCDM model.
description: 12 pages, 16 figures, submitted to MNRAS
Additional file 9 of Identification and distribution of gene clusters required for synthesis of sphingolipid metabolism inhibitors in diverse species of the filamentous fungus Fusarium
Creators: name: Hye-Seon Kim
name: Lohmar, Jessica M.
name: Busman, Mark
name: Brown, Daren W.
name: Naumann, Todd A.
name: Divon, Hege H.
name: Uhlig, Silvio
name: Proctor, Robert H.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 9. Proposed sphingofungin C biosynthetic pathway inferred by comparison of the chemical structure of sphingofungin C and the content of enzyme-encoding genes in the putative sphingofungin biosynthetic gene cluster. Proposed functions of genes in the putative sphingofungin biosynthetic gene cluster based on sequence homology to genes of known function (Additional file 9 Table 1). Arrangement of genes in the putative sphingofungin biosynthetic gene cluster. Arrows represent genes and point in the direction of transcription. The designations for the 13 genes in the cluster are Afu3g14670 – Afu3g14770, Afu3g14790 and Afug14800. However, only the last three digits of these designations are shown above the genes in the figure. Genes encoding the PKS, AT and SDR enzymes are indicated (Additional file 9 Figure 1). Proposed sphingofungin C biosynthetic pathway (Additional file 9 Figure 2).
Mapping the Tertiary Structure of RNAs using SHAPE-JuMP
Creators: name: Osta, Amanda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Function is closely related to form in biological systems, and one of the more recent advancements in structure-function relationships is in our rapidly expanding understanding of the tertiary structure of RNA. The ability of an RNA to fold back on itself and form tertiary interactions affects catalysis, protein synthesis, and assembly of ribonucleoprotein complexes.1,2 Here, we utilize SHAPE-JuMP (selective 2’-hydroxyl acylation analyzed by primer extension with juxtaposed merged pairs) to examine the tertiary structure of RNAs. SHAPE-JuMP is a technology developed in the Weeks laboratory. It uses an RNA crosslinker trans-bis-isatoic anhydride (TBIA), reverse transcription, sequencing, and computational analysis to reveal where RNA interactions occur in three-dimensional space. We show that reverse transcriptase C8 can successfully locate cross-links in RNase P, mapping RNase P’s tertiary structure using SHAPE-JuMP. We also reveal that the C8 polymerase can successfully reverse transcribe the random-primed 16S subunit of E. coli ribosomal RNA. The 16S rRNA subunit is 1533 nucleotides in length, which suggests that performing SHAPE-JuMP experiments on longer RNAs with the C8 polymerase is feasible, and may ultimately reveal their three-dimensional structures. When fully realized, this project will serve as a model system for measuring and understanding the spatial dynamics of RNA.
Additional file 4 of Identification and distribution of gene clusters required for synthesis of sphingolipid metabolism inhibitors in diverse species of the filamentous fungus Fusarium
Creators: name: Hye-Seon Kim
name: Lohmar, Jessica M.
name: Busman, Mark
name: Brown, Daren W.
name: Naumann, Todd A.
name: Divon, Hege H.
name: Uhlig, Silvio
name: Proctor, Robert H.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 4. Distribution of SAM clusters in 87 representative Fusarium genome sequences.
Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis
Creators: name: Singh, Karan
name: Sachan, Nalani
name: Ene, Taylor
name: Dabovic, Branka
name: Rifkin, Daniel
Publisher: name: Zenodo
Year: 2022
Subjects: Transforming growth factor-beta
latent TGFβ binding protein 3
adipogenesis
peroxisome proliferator-activated receptor γ
bone marrow mesenchymal stem cells.

description: Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein (LTBP) or glycoprotein-A repetitions predominant (GARP) protein. LTBP1 and 3 modulate latent TGFβ function with respect to secretion, matrix localization, and activation and, therefore, are vital for the proper function of the cytokine in a number of tissues. TGFβ modulates stem cell differentiation into adipocytes (adipogenesis), but the potential role of LTBPs in this process has not been studied. We observed that 72 h post adipogenesis initiation Ltbp1, 2, and 4 expression levels decrease by 74-84%, whereas Ltbp3 expression levels remain constant during adipogenesis. We found that LTBP3 silencing in C3H/10T1/2 cells reduced adipogenesis, as measured by the percentage of cells with lipid vesicles and the expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ). Lentiviral mediated expression of an Ltbp3 mRNA resistant to siRNA targeting rescued the phenotype, validating siRNA specificity. Knockdown (KD) of Ltbp3 expression in 3T3-L1, M2, and primary bone marrow stromal cells (BMSC) indicated a similar requirement for Ltbp3. Epididymal and inguinal white adipose tissue fat pad weights of Ltbp3-/- mice were reduced by 62% and 57%, respectively, compared to wild-type mice. Inhibition of adipogenic differentiation upon LTBP3 loss is mediated by TGFβ, as TGFβ neutralizing antibody and TGFβ receptor I kinase blockade rescue the LTBP3 KD phenotype. These results indicate that LTBP3 has a TGFβ-dependent function in adipogenesis both in vitro and possibly in vivo.
description: ExcelFunding provided by: National Heart, 845 Lung, and Blood Institute*
Crossref Funder Registry ID:
Award Number: 5 P01HL134605-03
description: Please look at the method section of the manuscript.
Incarnations of Berthelot's conjecture
Creators: name: Lazda, Christopher
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14F30

description: In this article we give a survey of the various forms of Berthelot's conjecture and some of the implications between them. By proving some comparison results between pushforwards of overconvergent isocrystals and those of arithmetic $\mathcal{D}$-modules, we manage to deduce some cases of the conjecture from Caro's results on the stability of overcoherence under pushforward via a smooth and proper morphism of varieties. In particular, we show that Ogus' convergent pushforward of an overconvergent $F$-isocrystal under a smooth and projective morphism is overconvergent.
description: 17 pages. Final version, published in J. Number Theory
Extragalactic SETI
Creators: name: Garrett, Mike
name: Siemion, Andrew
Publisher: name: Zenodo
Year: 2022

description: Abstract: The Breakthrough Listen Initiative has embarked on a comprehensive SETI survey of nearby stars in the Milky Way that is vastly superior to previous efforts as measured by a wide range of different metrics. SETI surveys traditionally ignore the fact that they are sensitive to many background objects, in addition to the foreground target star. In order to better appreciate and exploit the presence of extragalactic objects in the field of view, the Aladin sky atlas and NED were employed to make a rudimentary census of extragalactic objects that were serendipitously observed by the 100-m Greenbank telescope observing at 1.1-1.9 GHz. For 469 target fields (assuming a FWHM radial field-of-view of 4.2 arcminutes), NED identified a grand total of 143024 extragalactic objects, including various astrophysical exotica e.g. AGN of various type, radio galaxies, interacting galaxies, and one confirmed gravitational lens system. Several nearby galaxies, galaxy groups and galaxy clusters are identified, permitting the parameter space probed by SETI surveys to be significantly extended. New constraints are placed on the luminosity function of potential extraterrestrial transmitters and limits on the prevalence of very powerful extraterrestrial transmitters associated with these vast stellar systems are also determined. It is demonstrated that the recent Breakthrough Listen Initiative, and indeed many previous SETI radio surveys, place stronger limits on the prevalence of extraterrestrial intelligence in the distant Universe than is often fully appreciated.
Data from: Testing hypotheses of marsupial brain size variation using phylogenetic multiple imputations and a Bayesian comparative framework
Creators: name: S. Todorov, Orlin
Publisher: name: Zenodo
Year: 2022

description: Considerable controversy exists about which hypotheses and variables best explain mammalian brain size variation. We use a new, high-coverage dataset of marsupial brain and body sizes, and the first phylogenetically imputed full datasets of 16 predictor variables, to model the prevalent hypotheses explaining brain size evolution using phylogenetically corrected Bayesian generalised linear mixed-effects modelling. Despite this comprehensive analysis, litter size emerges as the only significant predictor. Marsupials differ from the more frequently studied placentals in displaying much lower diversity of reproductive traits, which are known to interact extensively with many behavioural and ecological predictors of brain size. Our results therefore suggest that studies of relative brain size evolution in placental mammals may require targeted co-analysis or adjustment of reproductive parameters like litter size, weaning age, or gestation length. This supports suggestions that significant associations between behavioural or ecological variables with relative brain size may be due to a confounding influence of the extensive reproductive diversity of placental mammals.
(3732) Richard Gough Talbot
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cell-Mediated Drug Delivery as a Treatment to Inhibit Restenosis
Creators: name: Lutz, Halle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Cardiovascular diseases (CVDs) are the leading cause of death in the world. CVDs are typically due to atherosclerosis, a build-up of plaque that results in arterial blockage. Currently, the most common solution is balloon angioplasty surgery, which is only a temporary solution because even though the arteries are widened again, revascularization results in arterial injury. This injury triggers the body’s natural response: inflammation through the proliferation and migration of smooth muscle cells (SMC), narrowing the artery again—a process called restenosis—requiring further surgeries. Cinnamic aldehyde (CA) has been shown to inhibit SMC proliferation and migration by activating the Nrf2-Keap1 pathway, but it has a systemic effect. We aim to form a cell-mediated targeted drug delivery system using macrophages and micelle nanoparticles to transport CA to activate the Nrf2-Keap1 pathway and prevent restenosis. As a result of sparse data, the micelles were first characterized by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) to determine size (232.7 nm in diameter) to ensure the nanoparticles were large enough to be taken up by macrophages. Then, THP-1 macrophage uptake of rhodamine labeled micelles was studied by live-cell microscopy. Through Western Blot and 3-(4,5-Dimethylthiazol-2-Yl)- 2,5-Diphenyltetrazolium Bromide (MTT) assays, CA-loaded nanoparticles were found to activate the Nrf2-Keap1 pathway and inhibit vascular SMC proliferation, respectively. These results establish the groundwork for future investigation into pluronic micellar targeted delivery to prevent restenosis.
Pulsation frequency distribution in Delta Scuti stars
Creators: name: Balona, L. A.
name: Daszynska-Daszkiewicz, J.
name: Pamyatnykh, A. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study the frequency distributions of Delta Scuti stars observed by the Kepler satellite in short-cadence mode. To minimize errors in the estimated stellar parameters, we divided the instability strip into ten regions and determined the mean frequency distribution in each region. We confirm that the presence of low frequencies is a property of all Delta Scuti stars, rendering meaningless the concept of Delta Sct/Gamma Dor hybrids. We obtained the true distribution of equatorial rotational velocities in each region and calculated the frequency distributions predicted by pulsation models, taking into account rotational splitting of the frequencies. We confirm that rotation cannot account for the presence of low frequencies. We calculated a large variety of standard pulsation models with different metal and helium abundances, but were unable to obtain unstable low-frequency modes driven by the kappa mechanism in any model. We also constructed models with modified opacities in the envelope. Increasing the opacity at a temperature log T = 5.06 by a factor of two does lead to instability of low-degree modes at low frequencies, but also decreases the frequency range of Delta Sct-type pulsations to some extent. We also re-affirm the fact that less than half of the stars in the Delta Sct instability strip have pulsations detectable by Kepler. We also point out the huge variety of frequency patterns in stars with roughly similar parameters, suggesting that nonlinearity is an important factor in Delta Sct pulsations.
description: 11 pages, 7 figures. 1 table
A Boundedness theorem for nearby slopes of holonomic D-modules
Creators: name: Teyssier, Jean-Baptiste
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Using twisted nearby cycles, we define a new notion of slopes for complex holonomic D-modules. We prove a boundedness result for these slopes, study their functoriality and use them to characterize regularity. For a family of (possibly irregular) algebraic connections E\_t parametrized by a smooth curve, we deduce under natural conditions an explicit bound for the usual slopes of the differential equation satisfied by the family of irregular periods of the E\_t. This generalizes the regularity of the Gauss-Manin connection proved by Katz and Deligne. Finally, we address some questions about analogues of the above results for wild ramification in the arithmetic context.
Using Standardized Clinical Vignettes to Assess Village Doctors’ Knowledge in Rural China
Creators: name: Guo, Wilson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Background: In the past two decades, China has focused on expanding primary care services in its rural areas through investments and policy interventions, resulting in increased healthcare utilization and expenditure. Despite these measures, there is still no clear evidence that patients in rural areas have experienced improved quality of care. Our study was the first nationally-representative assessment of village doctors’ knowledge in China and used knowledge measures to represent the care that patients receive.Methods: Village doctor and clinic surveys were conducted in randomly selected clinics to collect characteristic information. We evaluated the knowledge of clinicians using standard clinical vignettes through four domains: questions asked, examinations performed, diagnosis given, and treatment provided. These domains were measured using clinical checklists and standards based on Chinese national guidelines. We used multivariate linear regression to assess correlates of physician knowledge.Results: Village doctors surveyed in this study were mainly male, have several years of practicing experience, and have low levels of general and medical education. All clinics surveyed had thermometers, stethoscopes, and sphygmomanometers - three medical instruments needed for the recommended examinations of unstable angina. Village doctors had low levels of adherence to clinical checklists. Only 24.5% of recommended and 35.9% of essential questions and examinations were completed by surveyed village doctors. For diagnosis and treatment, 20.3% of village doctors gave correct diagnoses, while 7.2% prescribed correct medications and 60.1% correctly referred the patient to upper-tier providers. Correlates of process quality included age and experience for village doctors, varieties of medicine and value of medical instruments for clinics, as well as diagnosis and treatment. Conclusion: Our study indicates that the knowledge levels among village doctors is a major barrier to improving the quality of care available to patients in rural areas of China. Efforts should be made to improve the quality of primary care available in rural areas; however, further research is needed to identify effective policy interventions.
(3733) Ernest Talbot Jordan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A New Catalogue of Type 1 AGN and its Implication on the AGN Unified Model
Creators: name: Oh, Kyuseok
name: Yi, Sukyoung K.
name: Schawinski, Kevin
name: Koss, Michael
name: Trakhtenbrot, Benny
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have newly identified a substantial number of type 1 active galactic nuclei (AGN) featuring weak broad-line regions (BLRs) at z < 0.2 from detailed analysis of galaxy spectra in the Sloan Digital Sky Survey Data Release 7. These objects predominantly show a stellar continuum but also a broad H-alpha emission line, indicating the presence of a low-luminosity AGN oriented so that we are viewing the central engine directly without significant obscuration. These accreting black holes have previously eluded detection due to their weak nature. The new BLR AGNs we found increased the number of known type 1 AGNs by 49%. Some of these new BLR AGNs were detected at the Chandra X-ray Observatory, and their X-ray properties confirm that they are indeed type 1 AGN. Based on our new and more complete catalogue of type 1 AGNs, we derived the type 1 fraction of AGNs as a function of [OIII] 5007 emission luminosity and explored the possible dilution effect on the obscured AGN due to star-formation. The new type 1 AGN fraction shows much more complex behavior with respect to black hole mass and bolometric luminosity than suggested by the existing receding torus model. The type 1 AGN fraction is sensitive to both of these factors, and there seems to be a sweet spot (ridge) in the diagram of black hole mass and bolometric luminosity. Furthermore, we present a hint that the Eddington ratio plays a role in determining the opening angles.
description: Accepted for publication in ApJS. 17 pages including 17 figures and 9 tables. 2 machine-readable tables to appear online
INFLUÊNCIA DO ESTÁGIO FENOLÓGICO DO MILHO NO DESENVOLVIMENTO DE SPODOPTERA FRUGIPERDA (J. E. SMITH, 1797) (LEPIDOPTERA: NOCTUIDAE)
Creators: name: da Silva, Aldeni Barbosa
Publisher: name: Zenodo
Year: 2023

description: Este trabalho foi realizado objetivando-se avaliar o desenvolvimento de S. frugiperda na planta do milho em diferentes estágios fenológicos e na espiga do milho. A pesquisa foi conduzida à temperatura de 25 ± 2 ºC, umidade relativa de 70 ± 10% e fotofase de 14 horas. Foram utilizadas lagartas de S. frugiperda provenientes da criação de manutenção do laboratório de controle biológico/UEPB. Através de observações diárias, determinou-se a duração, largura da cápsula cefálica e viabilidade dos estágios larval, pré-pupal e pupal. Cada lagarta foi considerada uma repetição e o delineamento experimental utilizado foi o inteiramente casualizado. Lagartas de S. frugiperda criadas em folhas de milho no estágio de 4-6 folhas apresentaram uma menor duração e uma maior largura da cápsula cefálica, sendo a duração da fase pré-pupal superior para lagartas criadas em espiga de milho e em folhas de plantas de milho no estágio de 10-14 folhas. Houve uma redução na viabilidade de pré-pupas oriundas de lagartas criadas em espiga de milho, não ocorrendo diferença estatística na duração da fase pupal de lagartas criadas nos diferentes estágios fenológicos do milho. A viabilidade (ovo-adulto) foi menor quando S. frugiperda foi criada em espiga de milho.
Phagocytosis and Remyelination regulated by Macrophage/microglia Pyk2
Creators: name: Zhou, Liwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Multiple sclerosis (MS) is characterized by lesions in the central nervous system (CNS) consisting of dying mature oligodendrocytes, inflammatory response by immune cells, and subsequent demyelination of axons. Macrophages and other glial cells are essential in response to demyelination, but their role in the remyelination process is only partly known. Previous literature suggests a correlation between CNS remyelination and macrophage appearance at the site of damage. Here, the function of Proline-rich tyro-sine kinase 2 (Pyk2), a risk factor tied to neurological diseases including Alzheimer’s and Parkinson’s, is explored in macrophages and oligodendrocyte precursor cells in terms of MS. Our LFB-PAS histological stainings showed that the initial level of remye-lination in pyk2-/- mice was significantly higher than that in wild-type mice under cu-prizone administration, suggesting Pyk2 has an inhibitory effect on remyelination. In ad-dition, we demonstrated Pyk2 as an important mediator for phagocytosis and signal transduction pathway in macrophage activation. Finally, secretome analysis identified neutrophilic granule protein (Ngp) being suppressed by Pyk2 in post-phagocytosis mac-rophages, which was further confirmed by Western blots and immunostaining results. Previous report suggests Ngp may subsequently inhibit Cathepsin B (Ctsb), which is thought to be elevated in various types of neurological diseases. By understanding the cellular function of Pyk2 and downstream expression of Ngp and its regulatory path-ways, we may explore potential therapeutic candidates curing MS.
Stratigraphy of Župna cerkev in Kranj Cemetery and Tipochronology of Early Medieval Jewellery
Creators: name: Rihter, Jernej
Publisher: name: Zenodo
Year: 2023
Subjects: archaeology, cemetery stratigraphy, early medieval jewellery, classification, dating method, typochronology, Slovenia, Kranj

description: The dissertation titled Stratigraphy of Župna cerkev in Kranj Cemetery and Tipochronology of Early Medieval Jewellery, had two objectives: to study the stratigraphy of the cemetery and, with its help, establish a typochronology of the early medieval head circlets and rings.
The Role of Health Policy in Improving End-of-Life Care Access and Quality: A Qualitative Study of Bereaved Caregivers
Creators: name: Berrier, Anna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: OBJECTIVES: Goal-concordant care aligns treatment with patient preferences and is considered the quality standard for end-of-life care. Despite communicating care preferences with clinicians and caregivers, many patients fail to receive end-of-life care that aligns with their goals and values. This raises concerns about structural elements of health systems that fail to elicit patient preferences and ensure they are incorporated into end-of-life care plans. This study assessed bereaved caregiver perspectives to gain a better understanding of the progression of end-of-life care, with a particular focus on issues related to accessing high-quality care that may be amenable to policy solutions.METHODS: We conducted semi-structured interviews with 19 bereaved caregivers of seriously ill patients who received care in Boston, Massachusetts and who died in the prior six months. Caregivers were asked to describe the patient’s progression of illness and medical care in the last six months of life, along with factors that were perceived to have impacted overall quality of care. Interviews were transcribed and analyzed through an iterative process.RESULTS: Participants discussed several elements of end-of-life care related to access and quality that acted as barriers to achieving high-quality care for patients. According to caregivers, the majority of patients (n=17) stated a preference to die with hospice but cited insurance coverage restrictions and finances as top barriers to hospice enrollment. When reflecting on quality of end-of-life care, caregivers reported clinician communication as a major area for improvement, particularly coordination of care surrounding patient transfer from one setting to another. Caregiver burden also impacted quality of care, with many caregivers stating that lacking a social support network exacerbated their own distress and limited their ability to support care that aligned with patients’ preferences.CONCLUSIONS: Seriously ill patients and their caregivers face challenges to accessing high-quality end-of-life care that is consistent with their preferences. In order to be more effective in meeting the needs of these patients, health systems require greater infrastructure to support effective insurance coverage, protections against the high cost of care, clinician communication, and caregiver support. Health policy levers, specifically federal-level health reform through the Medicare program, may be most effective in addressing concerns of access and quality to expand high-quality care to a greater proportion of beneficiaries. In connecting more individuals with care that is sensitive to their unique needs and goals, health policy may also begin to reshape societal approaches to death and dying in the U.S.
(3728) Florence Ethel Jordan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NASA TOPS at the United Nations 3rd Annual Open Science Conference
Creators: name: Gentmann, Chelle
name: Murphy, Kevin
name: Ivey, Yvonne
Publisher: name: Zenodo
Year: 2023

description: Dr. Chelle Gentemann represents NASA's Transform to Open Science program at the United Nations 3rd Open Science Conference, February 8, 2023. Dr. Gentemann is part of a panel: Strengthening the science-policy-society interface (policy-making).
Few-nucleon systems with state-of-the-art chiral nucleon-nucleon forces
Creators: name: Binder, S.
name: Calci, A.
name: Epelbaum, E.
name: Furnstahl, R. J.
name: Golak, J.
name: Hebeler, K.
name: Kamada, H.
name: Krebs, H.
name: Langhammer, J.
name: Liebig, S.
name: Maris, P.
name: Meißner, U. -G.
name: Minossi, D.
name: Nogga, A.
name: Potter, H.
name: Roth, R.
name: Skibinski, R.
name: Topolnicki, K.
name: Vary, J. P.
name: Witala, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We apply improved nucleon-nucleon potentials up to fifth order in chiral effective field theory, along with a new analysis of the theoretical truncation errors, to study nucleon-deuteron (Nd) scattering and selected low-energy observables in 3H, 4He, and 6Li. Calculations beyond second order differ from experiment well outside the range of quantified uncertainties, providing truly unambiguous evidence for missing three-nucleon forces within the employed framework. The sizes of the required three-nucleon force contributions agree well with expectations based on Weinberg's power counting. We identify the energy range in elastic Nd scattering best suited to study three-nucleon force effects and estimate the achievable accuracy of theoretical predictions for various observables.
description: 5 pages, 5 figures
Coevolution Between Supermassive Black Holes and Bulges Is Not Via Internal Feedback Regulation But By Rationed Gas Supply Due To Angular Momentum Distribution
Creators: name: Cen, Renyue
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We reason that, without physical fine-tuning, neither the supermassive black holes (SMBHs) nor the stellar bulges can self-regulate or inter-regulate by driving away already fallen cold gas to produce the observed correlation between them. We suggest an alternative scenario where the observed mass ratios of the SMBHs to bulges reflect the angular momentum distribution of infallen gas such that the mass reaching the stable accretion disc is a small fraction of that reaching the bulge region, averaged over the cosmological time scales. We test this scenario using high resolution, large-scale cosmological hydrodynamic simulations (without AGN feedback), assuming the angular momentum distribution of gas landing in the bulge region to yield a Mestel disc that is supported by independent simulations resolving the Bondi radii of SMBHs. A mass ratio of $0.1-0.3\%$ between the very low angular momentum gas that free-falls to the sub-parsec region to accrete to the SMBH and the overall star formation rate is found. This ratio is found to increase with increasing redshift to within a factor of $\sim 2$, suggesting that the SMBH to bulge ratio is nearly redshift independent, with a modest increase with redshift, a testable prediction. Furthermore, the duty cycle of active galactic nuclei (AGN) with high Eddington ratios is expected to increase significantly with redshift. Finally, while SMBHs and bulges are found to coevolve on $\sim 30-150$Myr time scales or longer, there is indication that, on shorer time scales, the SMBH accretion rate and star formation may be less correlated.
description: 12 pages, 3 figures, accepted to ApJ Letters
Additional file 1 of Informing urban climate planning with high resolution data: the Hestia fossil fuel CO2 emissions for Baltimore, Maryland
Creators: name: Roest, Geoffrey S.
name: K. R. Gurney
name: S. M. Miller
name: J. Liang
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Detailed methodology and information for the distribution of nonpoint building emissions and onroad emissions.
Supplemental material for: The estrogen receptor α cistrome in human endometrium and epithelial organoids
Creators: name: Hewitt, Sylvia
name: Wu, San-pin
name: Wang, Tianyuang
name: Ray, Madhumita
name: Brolinson, Marja
name: Young, Steven
name: Spencer, Thomas
name: DeCherney, Alan
name: DeMayo, Francsco
Publisher: name: Zenodo
Year: 2022

description: Endometrial health is impacted by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor alpha (ESR1) cistromes and transcriptomes of endometrial biopsies taken from the proliferative and mid-secretory phases of the menstrual cycle together with hormonally stimulated endometrial epithelial organoids. The cycle stage specific ESR1 binding sites were determined by ChIPseq and then integrated with changes in gene expression from RNAseq data to infer candidate ESR1 targets in normal endometrium. Genes with ESR1 binding in whole endometrium were enriched for chromatin modification and regulation of cell proliferation. The distribution of ESR1 binding sites in organoids was more distal from gene promoters when compared to primary endometrium and was more similar to the proliferative than the mid-secretory phase ESR1 cistrome. Inferred organoid estrogen/ESR1 candidate target genes impacted formation of cellular protrusions, and chromatin modification. Comparison of signaling impacted by candidate ESR1 target genes in endometrium vs. organoids reveals enrichment of both overlapping and distinct responses. Our analysis of the ESR1 cistromes and transcriptomes from endometrium and organoids provides important resources for understanding how estrogen impacts endometrial health and function.
description: Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: Z1AES103311-01Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: Z1AHD008926Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: P01 HD106485Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: 1R01HD096266-04
Prepronociceptin neurons within the extended amygdala drive rapid changes in physiological arousal
Creators: name: Zhu, Xueqi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: 32% of Americans develop an anxiety disorder during their lifetime. Anxiety disorders are characterized by elevated anxiety states that are sustained in the absence of stimulus. Pathological anxiety implicates neural circuits that involve multiple brain regions. One such region is the bed nucleus of the stria terminalis (BNST), also known as the extended amygdala, which has emerged as a hub in networks that regulate anxiety. The BNST is a functionally heterogeneous region involved in various motivated behavioral states. In order to disentangle the complex role of the BNST in motivational states, we sought to study a unique neuronal population. We used a transgenic mouse line to target a subset of BNST neurons that express prepronociceptin (Pnoc), a genetic precursor to nociceptin, which is a neuropeptide traditionally implicated in pain studies. While presenting olfactory stimuli with positive or negative associations, we measured behavioral responses such as approach and avoidance of the stimulus, overall locomotion, and physiological responses that are indicative of arousal states. We found that stimuli with positive and negative valences affected approach and avoidance behavior and physiological responses, specifically changes in pupil size. Using a custom assay, we presented olfactory stimuli to head-fixed mice while simultaneously measuring pupil diameter, locomotion, and calcium activity from PnocBNST neurons. From these experiments, we observed that in the presence of aversive synthetic predator odor 2,4,5-trimethylthiazoline (TMT), PnocBNST neuron activity, pupil diameter and locomotion increase.  Next, we used optogenetic tools to activate PnocBNST neurons while simultaneously measuring pupil diameter and body movement. Activation of these neurons led to increases in pupil diameter without accompanying increases in body movement. Taken together, these findings suggest that PnocBNST neurons are involved in driving autonomic responses often characteristic of anxiety-like states, further suggesting that PnocBNST neurons could be a target for pharmacological interventions to reduce pathological anxiety.
(3729) Thomas Woodford Sallitt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3731) Monica Jean Herring
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Current uses and knowledge of medicinal plants in the Autonomous Community of Madrid (Spain): a descriptive cross-sectional study
Creators: name: Sánchez, Marta
name: González-Burgos, Elena
name: Iglesias, Irene
name: Lozano, Rafael
name: Gómez-Serranillos, María Pilar
Publisher: name: figshare
Year: 2020
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Survey on medicinal plants. The questionnaire was developed in Spanish language and designed for this study.