cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Moving on from the software engineers' gambit-Supplementary Material
Creators: name: Matsubara, Patrícia
name: Steinmacher, Igor
name: Gadelha, Bruno
name: Conte, Tayana
Publisher: name: figshare
Year: 2023
Subjects: Software engineering not elsewhere classified

description: We present the supplementary material for the paper: Moving on from the software engineers' gambit: an approach to support the defense of software effort estimates. It contains the questionnaires, the dataset, additional analysis, and the booklet with the defense lenses.
Investigating differences in treatment effect estimates between propensity score matching and weighting: A demonstration using STAR*D trial data
Creators: name: Dusetzina, Stacie B.
name: Ellis, Alan R.
name: Gaynes, Bradley N.
name: Stürmer, Til
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The choice of propensity score (PS) implementation influences treatment effect estimates not only because different methods estimate different quantities, but also because different estimators respond in different ways to phenomena such as treatment effect heterogeneity and limited availability of potential matches. Using effectiveness data, we describe lessons learned from sensitivity analyses with matched and weighted estimates.
Variable selection for propensity score models when estimating treatment effects on multiple outcomes: a simulation study: PS VARIABLE SELECTION FOR MULTIPLE OUTCOMES
Creators: name: Alan Brookhart, M.
name: Stürmer, Til
name: Girman, Cynthia J.
name: Wyss, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: It is often preferable to simplify the estimation of treatment effects on multiple outcomes by using a single propensity score (PS) model. Variable selection in PS models impacts the efficiency and validity of treatment effects. However, the impact of different variable selection strategies on the estimated treatment effects in settings involving multiple outcomes is not well understood. The authors use simulations to evaluate the impact of different variable selection strategies on the bias and precision of effect estimates to provide insight into the performance of various PS models in settings with multiple outcomes.
EVOLUTION AND MOLECULAR PHYLOGENY OF CRUSTACEA
Creators: name: Noel, P. Y.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1991

description: Morpho-anatomical evolution co-exists with molecular evolution in crustacea. Evolution seems to differ according to molecules. Sequences of neuropeptides begin to be elucidated: one for RPCH, two for PDH and FMRFamide, several for CHH/MIH/VIH. Molecular phylogeny is easier to investigate with nucleic acids (especially with ribosomal RNAs) than peptidic sequencing.
Evaluating the incident user design in the HIV population: incident use versus naive?
Creators: name: Moga, Daniela C.
name: Napravnik, Sonia
name: Eron, Joseph J.
name: Brouwer, Emily S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: INTRODUCTION: The incident user design is the preferred study design in comparative effectiveness (CER) research. Usually, 180-365 days of exposure free time is adequate to remove biases associated with inclusion of prevalent users. In HIV research, the use of antiretrovirals (ARVs) at any time in the past may influence future treatment choices and CER results; thus, identifying naive as opposed to incident users is of importance. We examined misclassification of antiretroviral naive status based on Medicaid administrative data through linkage to the UNC CFAR HIV Clinical Cohort (UCHCC).

METHODS: We identified Medicaid patients with incident exposure to common first-line ARV regimens between 2002 and 2008 that were also patients enrolled in the UCHCC. We calculated the proportion of antiretroviral naive patients based on the UCHCC, among patients identified as having incident exposure in Medicaid and examined factors associated with being antiretroviral naive in both data sources using logistic regression to generate prevalence odds ratios and associated 95% confidence intervals.

RESULTS: Of the 3500 Medicaid patients with incident antiretroviral (ARV) exposure, 1344 were also enrolled in the UCHCC. In this sample, 34% were antiretroviral naive at the time of first exposure in the Medicaid data based on the UCHCC. In multivariable models, higher CD4 cell counts and log HIV RNA values were associated with being antiretroviral naive in both data sources.

CONCLUSIONS: Administrative data are an important source of information related to HIV treatment. As the construction of a durable and long-lasting HIV treatment plan involves knowledge of current and past antiretroviral therapy, augmentation of this data with comprehensive clinical cohort information is necessary.
Matching on the disease risk score in comparative effectiveness research of new treatments: Matching on Disease Risk Scores
Creators: name: Simpson, Ross J.
name: Ellis, Alan R.
name: Brookhart, M. Alan
name: Girman, Cynthia J.
name: Stürmer, Til
name: Wyss, Richard
name: Jonsson Funk, Michele
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We use simulations and an empirical example to evaluate the performance of disease risk score (DRS) matching compared with propensity score (PS) matching when controlling large numbers of covariates in settings involving newly introduced treatments.
Supplementary Material and Methods, and Figures from Palaeo-trajectories of forest savannization in the southern Congo.
Creators: name: Aleman, Julie C.
name: Blarquez, Olivier
name: Elenga, Hilaire
name: Paillard, Jordan
name: Kimpuni, Victor
name: Gaubin Itoua
name: Issele, Gauthier
name: A. Carla Staver
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Tropical savannah and forest are thought to represent alternative stable states in ecosystem structure in some climates. The implication is that biomes are maintained by positive feedbacks, e.g. with fire, and that historical distributions could play a role in determining modern ones. In this context, climate alone does not govern transitions between biomes, and understanding the causes and pathways of such transitions becomes crucial. Here, we use a multi-proxy analysis of a 2000-year core to evaluate modes of transition in vegetation structure and fire regimes. We demonstrate a first transition ca 1540 BP, when a cyclic fire regime entered a forested landscape, eventually resulting, by ca 1060 BP, in a transition to a more open savannah-like or mosaicked structure. This pattern may parallel currently accelerating fire regimes in tropical forests suggesting that fires can savannize forests, but perhaps more slowly than feared. Finally, ca 540 BP, a drought combined with anthropogenic influences resulted in a conclusive transition to savannah, probably resembling the modern landscape in the region. We show here that fire interacted with drought to transition forest to savannah, suggesting that disturbance by fire can be a major driver of biome change.
Photogating of mono- and few-layer MoS2
Creators: name: Miller, Bastian
name: Parzinger, Eric
name: Vernickel, Anna
name: Holleitner, Alexander W.
name: Wurstbauer, Ursula
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We describe a photogating effect in mono- and few-layer MoS2, which allows the control of the charge carrier density by almost two orders of magnitude without electrical contacts. Our Raman studies are consistent with physisorbed environmental molecules, that effectively deplete the intrinsically n-doped charge carrier system via charge transfer, and which can be gradually removed by the exposure to light. This photogating process is reversible and precisely tunable by the light intensity. The photogating efficiency is quantified by comparison with measurements on electrostatically gated MoS2.
EVOLUTIONARY SIGNIFICANCE OF UREA, URIC-ACID AND GUANINE SYNTHESES
Creators: name: Schoffeniels, E.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1991

description: Urea synthesis is the evolutionary response to the passage of aquatic to terrestrial life. It is therefore reasonnable to assume that urea as osmotic effector in Elasmobranch fishes is a secondary adaptation the meaning of which from the standpoint of energy metabolism is discussed. This situation is compared to that of the Arthropods and more specifically to that of Crustacea where amino acids are osmotic effectors quantitatively the most important. Indeed 4M ATP are required to synthetize 1M of urea, while a mean of 30 ATP are necessary for the synthesis of 1M of amino acids.
Pegylated Interferon Pharmacokinetics and Self-Reported Depressive Symptoms During Antiviral Treatment for Chronic Hepatitis C
Creators: name: Esserman, D.
name: Howell, M.
name: Ruffin, R.
name: Evon, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Pegylated interferon-2a (PegIFN-2a) + ribavirin treatment for chronic hepatitis C is often associated with depressive symptoms. Previous studies have failed to explore whether PegIFN-2a pharmacokinetic variability plays an etiologic role in PegIFN-2a-induced mood disorders. The objective of this investigation was to evaluate the association between trough PegIFN-2a concentration at treatment week 4 (“PegIFN-2a Cmin4”) and an increase in depressive symptoms.
Carbon Nanotube-based Super Nanotube: Tailorable Thermal Conductivity at Three-dimensional
Creators: name: Zhan, Haifei
name: Bell, John M.
name: Gu, Yuantong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The advancements of nanomaterials or nanostructures have enabled the possibility of fabricating multifunctional materials that hold great promises in engineering applications. The carbon nanotube (CNT)-based nanostructure is one representative building block for such multifunctional materials. Based on a series of in silico studies, we report the tailorability of the thermal conductivity of a three-dimensional CNT-based nanostructure, i.e., the single wall CNT (SWNT)-based super nanotube (ST). It is shown that the thermal conductivity of STs varies with different connecting carbon rings, and the ST with longer constituent SWNTs and larger diameter yield to a smaller thermal conductivity. Further results reveal that the inverse of the ST thermal conductivity exhibits a good linear relationship with the inverse of its length. Particularly, it is found that the thermal conductivity exhibits an approximately proportional relationship with the inverse of the temperature, but appears insensitive to the axial strain due to its Poisson ratio. These results, in the one hand, provide a fundamental understanding of the thermal transport properties of the super carbon nanotubes conductivities of ST, and in the other hand shed lights on their future design or fabrication and engineering applications.
description: accepted in RSC Advances 2015
MORPHOLOGY OF THE ADHESIVE PAPILLAE OF SOME ASCIDIAN LARVAE
Creators: name: Turon, X.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1991

description: This paper presents a comparative study of the morphology of the adhesive papillae in the larvae of four ascidian species: Clavelina lepadiformis (Muller), Polysyncraton lacazei (Giard), Diplosoma spongiforme (Giard) and Ecteinascidia turbinata Herdman. The structure of the papillae varies greatly in these species, from a simple glandular epithelium to a complex structure with glandular, myoepithelial and sensory cells. The species studied cover a wide range of the variation in these organs within the group of the ascidians. Their morphology is discussed on a comparative basis, and in relation to previous studies of other species.
On the inverse transform of Laplace transforms that contain (products of) the parabolic cylinder function
Creators: name: Veestraeten, Dirk
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The Laplace transforms of the transition probability density and distribution functions for the Ornstein-Uhlenbeck process contain the product of two parabolic cylinder functions, namely D_{v}(x)D_{v}(y) and D_{v}(x)D_{v-1}(y), respectively. The inverse transforms of these products have as yet not been documented. However, the transition density and distribution functions can be obtained by alternatively applying Doob's transform to the Kolmogorov equation and casting the problem in terms of Brownian motion. Linking the resulting transition density and distribution functions to their Laplace transforms then specifies the inverse transforms to the aforementioned products of parabolic cylinder functions. These two results, the recurrence relation of the parabolic cylinder function and the properties of the Laplace transform then enable the calculation of inverse transforms also for countless other combinations in the orders of the parabolic cylinder functions such as D_{v}(x)D_{v-2}(y), D_{v+1}(x)D_{v-1}(y) and D_{v}(x)D_{v-3}(y).
Supplementary Material and Methods, and Figures from Palaeo-trajectories of forest savannization in the southern Congo
Creators: name: Aleman, Julie C.
name: Blarquez, Olivier
name: Elenga, Hilaire
name: Paillard, Jordan
name: Kimpuni, Victor
name: Gaubin Itoua
name: Issele, Gauthier
name: A. Carla Staver
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Tropical savannah and forest are thought to represent alternative stable states in ecosystem structure in some climates. The implication is that biomes are maintained by positive feedbacks, e.g. with fire, and that historical distributions could play a role in determining modern ones. In this context, climate alone does not govern transitions between biomes, and understanding the causes and pathways of such transitions becomes crucial. Here, we use a multi-proxy analysis of a 2000-year core to evaluate modes of transition in vegetation structure and fire regimes. We demonstrate a first transition ca 1540 BP, when a cyclic fire regime entered a forested landscape, eventually resulting, by ca 1060 BP, in a transition to a more open savannah-like or mosaicked structure. This pattern may parallel currently accelerating fire regimes in tropical forests suggesting that fires can savannize forests, but perhaps more slowly than feared. Finally, ca 540 BP, a drought combined with anthropogenic influences resulted in a conclusive transition to savannah, probably resembling the modern landscape in the region. We show here that fire interacted with drought to transition forest to savannah, suggesting that disturbance by fire can be a major driver of biome change.
GENETIC POLYCHROMATISM AND SEX DETERMINATION IN SYNISOMA-MEDITERRANEA (ISOPODA VALVIFERA)
Creators: name: Rezig, M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1991

description: The Synisoma, Isopoda Valvifera present a very rich polychromatism. The genetic analysis of this polymorphism allowed us to deal with the study of the sex determination in this type of animals. Six species of Synisoma have been so far discovered on the Tunisian coastal line. S. mediterranea n.sp. has been particulary studied. Three major phenotypes of colouring: albafusca, bilineata and nigrocephala have been described and studied in comparison with a fundamental phenotype uniformis. The female sex in S.m. is heterogametic (WZ) while the male sex is homogametic (ZZ).
Habitat controls on vent food webs at Eifuku Volcano, Mariana Arc
Creators: name: LIMÉN, Helene
name: JUNIPER, S. Kim
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2006

description: We studied food web characteristics at three contrasting habitats on the slopes of NW Eifuku volcano in the
 Northern Mariana Arc, using stable carbon and nitrogen isotopes. The broad and apparently stable plume of hydrothermal
 flow that was being advected from Champagne site to the Mussel Bed area supported an extensive, high biomass commu-
 nity with a wide trophic base and several levels of consumers. The other two sites, with intense and unstable, or weak
 hydrothermal regimes, hosted simpler food webs. 13C-enrichment in samples from the vigorously venting environment at
 Champagne site suggests a strong input of chemosynthesis using Rubisco form II, although this factor alone does not
 account for the degree of 13C enrichment. In contrast, δ13C depletion, attributable to form I Rubisco or possibly methano-
 trophy, was observed in the mussels at the other two sites that were receiving advected or weak local hydrothermal flow.
 At Mussel Bed site, where mussels predominated, this 13C-depleted carbon also contributed to the diet of other species,
 whereas consumers at Top Tower site did not appear to be relying on carbon produced by the isolated mussels found at this
 site.
Supplemental Appendix from Hepatitis C virus modelled as an indirectly transmitted infection highlights the centrality of injection drug equipment in disease dynamics.
Creators: name: Miller-Dickson, Miles D.
name: Meszaros, Victor A.
name: Almagro-Moreno, Salvador
name: C. B. Ogbunugafor
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Additional discussion and analyses that are relevant to the study.
Institutional Review Board Barriers and Solutions Encountered in the Collaboration Among Pharmacists and Physicians to Improve Outcomes Now Study: A National Multicenter Practice-Based Implementation Trial
Creators: name: MacLaughlin, Eric J.
name: Young, Rodney B.
name: Carter, Barry L.
name: Ives, Timothy J.
name: Jackson, Eric A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To categorize institutional review board (IRB) challenges and solutions encountered in a multicenter, practice-based research network (PBRN) study and to assess the impact of IRB requirements on individual principal investigators’ (PIs’) willingness to participate in future PBRN studies.
Supplemental Appendix from Hepatitis C virus modelled as an indirectly transmitted infection highlights the centrality of injection drug equipment in disease dynamics
Creators: name: Miller-Dickson, Miles D.
name: Meszaros, Victor A.
name: Almagro-Moreno, Salvador
name: C. B. Ogbunugafor
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Additional discussion and analyses that are relevant to the study.
$1/m$ Corrections for Orbitally Excited Heavy Mesons and the $1/2$ - $3/2$ Puzzle
Creators: name: Klein, Rebecca
name: Mannel, Thomas
name: Shahriaran, Farnoush
name: van Dyk, Danny
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We re-investigate the effects of the $1/m_c$ corrections on the spectrum of the lowest orbitally excited $D$-meson states. We argue that one should expect the $1/m_c$ corrections to induce a significant mixing between the two lowest lying $1^+$ states. We discuss the implications of this mixing and compute its effect on the semileptonic decays $B \to D^{**} \ell \barν$ and the strong $D^{**}$ decays.
description: 9 pages, 3 figures
In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases
Creators: name: Nolin, Thomas D.
name: Frye, Reginald F.
name: Joy, Melanie S.
name: Roberts, Brittney V.
name: Falk, Ronald J.
name: Wang, Jinzhao
name: Dooley, Mary Anne
name: La, Mary K.
name: Brouwer, Kim L.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: This study was designed to prospectively evaluate the in vivo activities of drug transporters, metabolizing enzymes and pharmacokinetics in patients with chronic kidney diseases (CKD) caused by glomerulonephritis and non-glomerular etiologies.
Nematode communities associated with tubeworm and mussel aggregations on the East Pacific Rise
Creators: name: ZEKELY, Julia
name: GOLLNER, Sabine
name: DOVER, Cindy Lee Van
name: GOVENAR, Breea
name: BRIS, Nadine Le
name: NEMESCHKAL, Hans Leo
name: BRIGHT, Monika
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2006

description: The meiobenthic nematode community of three different vent sites at the East Pacific Rise was studied in order
 to determine whether the abundance, species richness, diversity and trophic structure were similar. The sites Tica and Riftia
 Field were dominated by the tubeworm Riftia pachyptila, and the Buckfield site was dominated by the mussel
 Bathymodiolus thermophilus. The nematode communities of all three sites were low in abundance (< 1 up to 46 ind. 10
 cm–2), except one sample from Tica with almost 1000 ind. 10 cm-2. The communities at all sites consisted entirely of
 primary consumers, mostly deposit feeders. Species richness and Shannon-Wiener diversity indices were low and similar
 at both tubeworm sites and slightly but significantly higher at the mussel site. Multivariate analysis revealed that the species
 dissimilarity among the three sites was greater than 50 %, indicating distinct communities at each site.
Predictors of Gastrointestinal Bleeding Among Patients with Atrial Fibrillation After Initiating Dabigatran Therapy
Creators: name: Farley, Joel F.
name: Fang, Gang
name: Gehi, Anil K.
name: Rhoney, Denise H.
name: Lauffenburger, Julie C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To identify demographic and clinical risk factors associated with gastrointestinal (GI) bleeding among a large cohort of patients with atrial fibrillation (AF) who initiated dabigatran therapy for stroke prevention, and to describe patterns of subsequent anticoagulant use after occurrence of the GI bleeding event.
Cyclobutane Pyrimidine Dimer Density as a Predictive Biomarker of the Biological Effects of Ultraviolet Radiation in Normal Human Fibroblast
Creators: name: Rao, Shangbang
name: Kaufmann, William K.
name: Cordeiro-Stone, Marila
name: Ibrahim, Joseph G.
name: Mitchell, David L.
name: Sproul, Christopher D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: This study compared biological responses of normal human fibroblasts (NHF1) to three sources of ultraviolet radiation (UVR), emitting UVC wavelengths, UVB wavelengths, or a combination of UVA and UVB (solar simulator; emission spectrum, 94.3% UVA and 5.7% UVB). The endpoints measured were cytotoxicity, intra-S checkpoint activation, inhibition of DNA replication and mutagenicity. Results show that the magnitude of each response to the indicated radiation sources was best predicted by the density of DNA cyclobutane pyrimidine dimers (CPD). The density of 6-4 pyrimidine–pyrimidone photoproducts was highest in DNA from UVC-irradiated cells (14% of CPD) as compared to those exposed to UVB (11%) or UVA–UVB (7%). The solar simulator source, under the experimental conditions described here, did not induce the formation of 8-oxo-7,8-dihydroguanine in NHF1 above background levels. Taken together, these results suggest that CPD play a dominant role in DNA damage responses and highlight the importance of using endogenous biomarkers to compare and report biological effects induced by different sources of UVR.
Rearing and observation methods of vestimentiferan tubeworm and its early development at atmospheric pressure
Creators: name: MIYAKE, Hiroshi
name: TSUKAHARA, Junzo
name: HASHIMOTO, Jun
name: UEMATSU, Katsuyuki
name: MARUYAMA, Tadashi
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2006

description: Vestimentiferan tubeworms are kept year-round at the Enoshima Aquarium and JAMSTEC. The tanks of
 vestimentiferan tubeworms have controlled low dissolved oxygen concentrations and added Na2S and CO2 to keep the
 animals in good condition. In addition, in order to observe vestimentiferan tubeworm behavior in its tube, vestimentiferan
 tubeworms have been placed into transparent vinyl tubes. The larval development of the vestimentiferan species
 Lamellibrachia satsuma was observed. Monospermy fertilization of oocytes by internal fertilization was observed.
 Fertilized eggs developed into trochophores and settled on the bottom of culture vessels. Scanning electron microscopy
 revealed a mouth in the trochophore stage after settlement. Bacteria were observed on the cilia of the mouth and in the guts
 of trochophores. Trochophores may eat microorganisms such as bacteria. Larvae which did not attach to suitable substrata
 swam for more than one month without any degeneration of the cilia ring. The larvae of L. satsuma were maintained in the
 laboratory for 45 days. L. satsuma have been found at Kagoshima Bay, Nankai Trough, and Izu-Ogasawara Ridge. The fast
 current speed of the Kuroshio (Black Current) and the length of the planktonic larval life of L. satsuma may have enabled
 this species to distribute in the Kuroshio Subgyre area.
Searches for scalar leptoquarks in $pp$ collisions at $\sqrt{s}$ = 8 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Searches for pair-produced scalar leptoquarks are performed using 20 fb$^{-1}$ of proton-proton collision data provided by the LHC and recorded by the ATLAS detector at $\sqrt{s}=8$ TeV. Events with two electrons (muons) and two or more jets in the final state are used to search for first (second)-generation leptoquarks. The results from two previously published ATLAS analyses are interpreted in terms of third-generation leptoquarks decaying to $bν_τ\bar{b}\bar{ν_τ}$ and $tν_τ\bar{t}\bar{ν_τ}$ final states. No statistically significant excess above the Standard Model expectation is observed in any channel and scalar leptoquarks are excluded at 95% CL with masses up to $m_{\mathrm{LQ1}}$ < 1050 GeV for first-generation leptoquarks, $m_{\mathrm{LQ2}}$ < 1000 GeV for second-generation leptoquarks, $m_{\mathrm{LQ3}} < $ 625 GeV for third-generation leptoquarks in the $bν_τ\bar{b}\bar{ν_τ}$ channel, and 200 $< m_{\mathrm{LQ3}} < $ 640 GeV in the $tν_τ\bar{t}\bar{ν_τ}$ channel.
description: 25 pages plus author list + cover pages (42 pages total), 6 figures, 8 tables, submitted to EPJC, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2014-03/
FREQUENCY AND MORPHOLOGY OF PSEUDOHERMAPHRODITISM IN SOME STENOGLOSSATE PROSOBRANCHIA OF MORLAIX BAY AND THE ENGLISH-CHANNEL .1. STATUS DURING SPRING 1988
Creators: name: Fioroni, P.
name: Stroben, E.
name: Oehlmann, J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1991

description: The frequence of the pseudohermaphroditism is analysed in 589 individuals of 5 Prosobranch species of the Bay of Morlaix (namely Roscoff) and of the french coast of the Channel (Port-en-Bessin, Coutainville, Granville). The pseudohermaphroditism is demonstrated for the first time in Hinia (Nassarius) incrassata and confirmed for Roscoff in Nucella lapillus, Ocenebra erinacea, Buccinum undatum and Hinia (Nassarius) reticulata (Tabl. II and III). Six different morphological types are distinguished and the differences of the species are described (Table III and Fig. 1); the appearance of pseudohermaphroditic females males without a penis, but with a vas deferens of a various length is presented for the first time. The accentuated occurence of the pseudohermaphroditism in marinas and ports, already known by the literature, is confirmed as well in respect to the percentual frequence as to the intensity of morphological expression (Tabl. II and III). The continuous expansion of the pseudohermaphroditism is demonstrated; in several localities, where it was - between 1972 and 1978 - not present (Granville, Coutainville) or only in lower percentages, it is demonstrated in 1988 for the first time or confirmed in higher levels.
Supplementary material from Behavioural and life-history responses of mosquitofish to biologically inspired and interactive robotic predators.
Creators: name: Polverino, Giovanni
name: Karakaya, Mert
name: Spinello, Chiara
name: Vrishin R. Soman
name: Porfiri, Maurizio
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: Further details on materials and methods, along with additional results
DNA Damage Checkpoint Responses in the S Phase of Synchronized Diploid Human Fibroblasts
Creators: name: Chastain, Paul D.
name: Zhou, Yingchun C.
name: Cordeiro-Stone, Marila
name: Rao, Shangbang
name: Kaufmann, William K.
name: Ibrahim, Joseph G.
name: Brylawski, Bruna P.
name: Chu, Haitao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We investigated the hypothesis that the strength of the activation of the intra-S DNA damage checkpoint varies within the S phase. Synchronized diploid human fibroblasts were exposed to either 0 or 2.5 J m−2 UVC in early, mid- and late-S phase. The endpoints measured were the following: (1) radio-resistant DNA synthesis (RDS), (2) induction of Chk1 phosphorylation, (3) initiation of new replicons and (4) length of replication tracks synthesized after irradiation. RDS analysis showed that global DNA synthesis was inhibited by approximately the same extent (30 ± 12%), regardless of when during S phase the fibroblasts were exposed to UVC. Western blot analysis revealed that the UVC-induced phosphorylation of checkpoint kinase 1 (Chk1) on serine 345 was high in early and mid S but 10-fold lower in late S. DNA fiber immunostaining studies indicated that the replication fork displacement rate decreased in irradiated cells at the three time points examined; however, replicon initiation was inhibited strongly in early and mid S, but this response was attenuated in late S. These results suggest that the intra-S checkpoint activated by UVC-induced DNA damage is not as robust toward the end of S phase in its inhibition of the latest firing origins in human fibroblasts.
Quantitative trait loci for physical activity traits in mice
Creators: name: Lightfoot, J. Timothy
name: Pomp, Daniel
name: Kleeberger, Steven R.
name: Turner, Michael J.
name: Leamy, Larry J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel distance, duration, and speed of exercise. F2 animals (n = 310) derived from high active C57L/J and low active C3H/HeJ inbred strains were phenotyped for 21 days. After phenotyping, genotyping with a fully informative single-nucleotide polymorphism panel with an average intermarker interval of 13.7 cM was used. On all three activity indexes, sex and strain were significant factors, with the F2 animals similar to the high active C57L/J mice in both daily exercise distance and duration of exercise. In the F2 cohort, female mice ran significantly farther, longer, and faster than male mice. QTL analysis revealed no sex-specific QTL but at the 5% experimentwise significance level did identify one QTL for duration, one QTL for distance, and two QTL for speed. The QTL for duration (DUR13.1) and distance (DIST13.1) colocalized with the QTL for speed (SPD13.1). Each of these QTL accounted for ∼6% of the phenotypic variance, whereas SPD9.1 (chromosome 9, 7 cM) accounted for 11.3% of the phenotypic variation. DUR13.1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies.
Benthic community structure on two peaks of an erupting seamount:  Northwest Rota-1 Volcano, Mariana Arc, western Pacific
Creators: name: LIMÉN, Helene
name: JUNIPER, S. Kim
name: TUNNICLIFFE, Verena
name: CLÉMENT, Michel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2006

description: This study examined structural features of a vent ecosystem subject to perturbation by repeated underwater
 eruptive activity on NW Rota-1 Volcano in the Mariana Arc. Results provide insight into how chronic disturbance regimes
 shape vent ecosystems. A photosynthetically-based, deep-sea sessile community found on an inactive peak of NW Rota-1
 was completely absent from the volcanically and hydrothermally active peak, even away from the areas of venting. A
 slightly more complex community and food web occurred where fluids were venting through cemented lavas (versus
 volcaniclastic sand), underlining the importance of substratum stability to the vent fauna. Meiofauna abundance and
 sediment organic matter content were much lower at these vents, compared to the nearby inactive peak, pointing to the
 importance of organic matter accumulation for the establishment of meiofaunal communities on the volcanic substratum.
 Evidence for food partitioning and multiple organic matter sources indicates that these latter are fundamental features of
 even chronically disturbed vent communities.
Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra Performance Liquid Chromatography
Creators: name: Cech, Nadja B.
name: VanderMolen, Karen M.
name: Paine, Mary F.
name: Oberlies, Nicholas H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Grapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)-mediated metabolism and P-glycoprotein (P-gp)-mediated efflux, while flavonoids have been implicated as inhibitors of organic anion transporting polypeptide (OATP)-mediated absorptive uptake in the intestine. The potential for drug interactions with a food product necessitates an understanding of the expected concentrations of a suite of structurally diverse and potentially bioactive compounds.
DNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features
Creators: name: Zhou, Xin
name: Berwick, Marianne
name: Slater, Nathaniel A.
name: Moschos, Stergios J.
name: Ollila, David W.
name: Kuan, Pei-Fen
name: Conway, Kathleen
name: Thomas, Nancy E.
name: Parrish, Eloise
name: Hao, Honglin
name: Edmiston, Sharon N.
name: Groben, Pamela A.
name: Carson, Craig C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: DNA methylation studies have elucidated a methylation signature distinguishing primary melanomas from benign nevi and provided new insights about genes that may be important in melanoma development. However, it is unclear whether methylation differences among primary melanomas are related to tumor pathologic features with known clinical significance. We utilized the Illumina Golden Gate Cancer Panel array to investigate the methylation profiles of 47 primary cutaneous melanomas. Array-wide methylation patterns revealed a positive association of methylation with Breslow thickness and mutated BRAF, a negative association with mitotic rate, and a weak association with ulceration. Hierarchical clustering on CpG sites exhibiting the most variable methylation (n=235) divided the melanoma samples into three clusters, including a highly-methylated cluster that was positively associated with Breslow thickness and an intermediately-methylated cluster associated with Breslow thickness and mitotic rate. Our findings provide support for the existence of methylation-defined subsets in melanomas, with increased methylation associated with Breslow thickness.
Supplementary material from Behavioural and life-history responses of mosquitofish to biologically inspired and interactive robotic predators
Creators: name: Polverino, Giovanni
name: Karakaya, Mert
name: Spinello, Chiara
name: Vrishin R. Soman
name: Porfiri, Maurizio
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: Further details on materials and methods, along with additional results
MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors
Creators: name: Reiner, Anne
name: Busam, Klaus
name: Berwick, Marianne
name: Sharma, Ajay
name: Cust, Anne E.
name: Armstrong, Bruce K.
name: Thomas, Nancy E.
name: Kanetsky, Peter
name: Rosso, Stefano
name: White, Kirsten
name: Orlow, Irene
name: Gallagher, Richard P.
name: Zanetti, Roberto
name: Kricker, Anne
name: From, Lynn
name: Venn, Alison
name: Marrett, Loraine D.
name: Luo, Li
name: MacArthur, Jamie
name: Begg, Colin B.
name: Anton-Culver, Hoda
name: Dwyer, Terence
name: Gruber, Stephen B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A rare germline variant in the MITF (microphthalmia-associated transcription factor) gene, E318K, has been reported as associated with melanoma. We confirmed its independent association with melanoma (odds ratio (OR) 1.7, 95% Confidence Interval (CI) = 1.1, 2.7, p = 0.03); adjusted for age, sex, center, age*sex interaction, pigmentation characteristics, family history of melanoma and nevus density). In stratified analyses, carriage of MITF E318K was associated with melanoma more strongly in people with dark hair than fair hair (p for interaction, 0.03) and in those with no moles than some or many moles (p for interaction, <0.01). There was no evidence of interaction between MC1R “red hair variants” and MITF E318K. Moreover, risk of melanoma among carriers with “low risk” phenotypes was as great or greater than among those with “at risk” phenotypes with few exceptions.
Dynamical Analysis of Blocking Events: Spatial and Temporal Fluctuations of Covariant Lyapunov Vectors
Creators: name: Schubert, Sebastian
name: Lucarini, Valerio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: One of the most relevant weather regimes in the mid-latitudes atmosphere is the persistent deviation from the approximately zonally symmetric jet to the emergence of blocking patterns. Such configurations are usually connected to exceptional local stability properties of the flow which come along with an improved local forecast skills during the phenomenon. It is instead extremely hard to predict onset and decay of blockings. Covariant Lyapunov Vectors (CLVs) offer a suitable characterization of the linear stability of a chaotic flow, since they represent the full tangent linear dynamics by a covariant basis which explores linear perturbations at all time scales. Therefore, we assess whether CLVs feature a signature of the blockings. As a first step, we examine the CLVs for a quasi-geostrophic beta-plane 2-layer model in a periodic channel baroclinically driven by a meridional temperature gradient $ΔT$. An orographic forcing enhances the emergence of localized blocked regimes. We detect the blocking events with a Tibaldi-Molteni scheme adapted to the periodic channel. When blocking occurs, the global growth rates of the fastest growing CLVs are significantly higher. Hence, against intuition, the circulation is globally more unstable in blocked phases. Such an increase in the finite time Lyapunov exponents with respect to the long term average is attributed to stronger barotropic and baroclinic conversion in the case of high temperature gradients, while for low values of ΔT, the effect is only due to stronger barotropic instability. In order to determine the localization of the CLVs we compare the meridionally averaged variance of the CLVs during blocked and unblocked phases. We find that on average the variance of the CLVs is clustered around the center of blocking. These results show that the blocked flow affects all time scales and processes described by the CLVs.
description: 23 pages, 10 figures
GNATHIIDS OF NORTH-ATLANTIC .2. DESCRIPTION OF BATHYGNATHIA-MONODI NSP BENTHIC GNATHIID FROM BAY OF BISCAY - STUDY OF METAMERIC HETEROGENEITY OF PEREIOPODS
Creators: name: Cals, P.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1974

Abstract
Τσιγάρο: Το κάπνισμα στον αθλητισμό, ηλικιακά φάσματα καπνιστών αθλητών, ασκουμένων και μη – κατηγορίες καπνιστών
Creators: name: Κουρούδη, Αικατερίνη Γεωργίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Τσιγάρο
Νικοτίνη
Μονοξείδιο του άνθρακα
Πίσσα
Καρδιαγγειακό σύστημα
Αναπνευστικό σύστημα
Αναπαραγωγικό σύστημα
Αθλητική απόδοση
Cigarette
Nicotine
Carbon monoxide
Cigarette tar
Cardiovascular system
Respiratory system
Reproductive system
Sports performance

description: Στόχος της παρούσας διπλωματική εργασίας είναι η μελέτη του τσιγάρου από την ιστορία του και την προέλευσή του, μέχρι την δομή του, την πορεία του στον ανθρώπινο οργανισμό, καθώς και τον αντίκτυπό του σε αυτόν. Ακόμη, η εργασία αυτή αποσαφηνίζει την δράση των πιο βλαβερών χημικών συστατικών που περιλαμβάνονται στο τσιγάρο, τα ζωτικά όργανα που προσβάλλονται από κάποιες ασθένειες, τις αιτίες εθισμού του ανθρώπου στο τσιγάρο, τα στερητικά συμπτώματα που ενδέχεται κάποιος να παρουσιάσει, και τα μέσα απεξάρτησης από το κάπνισμα. Επιπλέον, πραγματοποιείται εκτενής αναφορά στην σημερινή πραγματικότητα, δηλαδή στις κατηγορίες καπνίσματος και τα είδη τσιγάρων. Μια πραγματικότητα που όλο κι εξελίσσεται παρασυρόμενη από την τεχνολογία, η οποία την αναπροσαρμόζει στις ανάγκες του ανθρώπου και στα δεδομένα που έρχονται στα χέρια της, δημιουργώντας διάφορες επιλογές και προτάσεις που μπορεί να τον εξυπηρετούν καλύτερα. Έτσι, το τσιγάρο αποκτούσε και αποκτά ακόμη και τώρα, διάφορες μορφές ανά τα χρόνια, πέραν της πιο γνωστής μορφής του, δηλαδή του συμβατικού τσιγάρου. Αμέσως μετά πραγματεύεται το ζήτημα του καπνίσματος στην άθληση, με ιδιαίτερη αναφορά στα προβλήματα που αντιμετωπίζει κάποιος όταν ασκείται, όντας καπνιστής. Τελειώνοντας, παρατίθενται στατιστικά δεδομένα από ερωτηματολόγιο που διανεμήθηκε σε έντυπη μορφή σε καπνιστές που ασχολούνται με την άθληση, με ερωτήσεις που περισυλλέγουν δεδομένα σχετικά με τις αθλητικές και καπνιστικές τους συνήθειες.
description: The purpose of this thesis is to study the cigarette from its history and its origin, to its structure, its course in the human body, and its impact on it. Furthermore, this paper clarifies the action of the most harmful chemical ingredients included in the cigarette, the vital organs affected by some diseases, the causes of human addiction to the cigarette, the deprivation symptoms that one may present, and the means of stop smoking. In addition, there is extensive reference to today's reality, namely smoking categories and cigarette types. A reality that is increasingly evolved by technology, which adapts it to the needs of human and to the data that comes into her hands, creating various choices and suggestions that can best serve him. Thus, the cigarette has acquired, various forms over the years, beyond its most well -known form, that is, the conventional cigarette. Immediately thereafter, the issue of smoking in sport addresses, with particular reference to the problems that one is facing when training as being a smoker. In conclusion, statistical data from a questionnaire distributed to smokers who do sports are listed, with questions collecting data on their sports and smoking habits.
Polarization entanglement and quantum beats of photon pairs from four-wave mixing in a cold Rb-87 ensemble
Creators: name: Gulati, Gurpreet Kaur
name: Srivathsan, Bharath
name: Chng, Brenda
name: Ceré, Alessandro
name: Kurtsiefer, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We characterize correlations in polarization and time of photon pairs generated from a cold cloud of Rb-87 atoms via a four-wave mixing process in a cascade level scheme. Quantum state tomography reveals entangled polarization states of high purity for each of the decay paths through two different intermediate hyperfine levels. When allowing both decay paths, we observe quantum beats in time-resolved correlation measurements.
description: 10 pages, 5 figures
Is temperature a good proxy for sulfide in hydrothermal vent habitats ?
Creators: name: LE BRIS, Nadine
name: RODIER, Philippe
name: SARRADIN, Pierre-Marie
name: LE GALL, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2006

description: On the basis of previous studies at 9°N and 13°N East Pacific Rise (EPR) fields, we discuss the general assump-
 tion that temperature is a proxy for sulfide in vent fauna habitat. The main conclusion of these works is illustrated here
 through selected examples. In situ measurements were used to assess the variability of chemical parameters as function of
 temperature at the scale of fauna aggregations. Over a single vent site, aggregations of mussels or Riftia pachyptila
 discretely distributed around diffuse vents exhibit, in first assumption, similar sulfide-temperature correlation. In contrast,
 sulfide is much higher, for a given temperature, in the habitat of alvinellids than in neighboring habitats of Riftia pachyptila.
 Some consistency in the sulfide-temperature correlation is also found when comparing diffuse vent habitats over distinct
 sites of the vent field, even when they are not dominated by the same species. In some case, however, this correlation
 departs substantially from the general trend. The variability in the iron-sulfide ratio in fluids between site is further expected
 to modulate sulfide biological impact. According to thermodynamic calculation, however, this factor appears to be more
 relevant when used to discriminate sulfide toxicity in alvinellid habitats than to conclude on the unavailability of sulfide to
 Riftia pachyptila populations at iron-rich sites. When direct in situ characterization is not available, these general conclu-
 sions should provide a first basis for the extrapolation of chemical features from temperature ranges in EPR habitats.