cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Active Fires Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00148
Bezugsbegrenzung bei Nullenergiegebäuden
Creators: name: Menn, Claudio
Publisher: name: Kanton Thurgau, Abteilung Energie
Year: 2015
Subjects: subject: net zero energy buildings
subject: Bezugsbegrenzung
subject: Nullenergiegebäude
subject: energetische Bilanzierung
subject: Bilanzierungskonzept
subject: Gebäudezertifizierung
subject: 624 - Ingenieurbau und Umwelttechnik
subject: 690 - Hausbau, Bauhandwerk

description: Die energetische Bilanzierung von Nullenergiegebäuden findet zumeist auf einer Jahresbasis statt. Diese Berechnungsgrundlage führt dazu, dass saisonale Unterschiede im Energiebedarf und in der Ertragslage erneuerbarer Energien unberücksichtigt bleiben. Für eine Energiewende ist allerdings die Energieversorgung während den Wintermonaten von zentraler Bedeutung. In diesem Zusammenhang stellt das alternative Bilanzierungskonzept mit einer Bezugsbegrenzung ein zielführendes Instrument dar. Es wird in vorliegendem Artikel exemplarisch aufgezeigt, mit welchen bauplanerischen Auswirkungen bei der Einführung einer Bezugsbegrenzung zu rechnen sind.
STFC Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for Science and Technology Facilities Council (STFC) grant application data management plans.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the STFC and the University of Sheffield Library.
STFC expects that data resulting from the research it funds should be made openly available after any proprietary period. Proposals for projects that would result in the production or collection of scientific data should include a data management plan as an attachment to the JeS proforma. The data management plan attachment is mandatory against most STFC schemes (not Public Engagement) and should be no longer than two pages of A4. STFC does not stipulate a specific format for data management plans and applicants may structure them in the way most appropriate to the project. If it is felt that a DMP is not relevant to a proposal then an attachment explaining this should be uploaded to pass validation. This, together with any costs associated with it, will be considered and assessed by the normal peer review process. The data management plan should explain how the data will be managed over the lifetime of the project and, where appropriate, preserved and shared for future re-use.
For more information, see the STFC scientific data policy, the STFC guidance on writing a data management plan and guidance on the data management review.
The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan.
Uterine Fibroids: Response to novel treatment modalities
Creators: name: Quinn, Stephen
Publisher: name: Imperial College London
Year: 2013

description: Introduction Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive, thermal ablation treatment for uterine fibroids. There is currently limited data regarding the long-term efficacy of this method and the effect of this treatment on circulating cytokine and growth factors. In this thesis I have: 1. Presented the most accurate method of measuring fibroid volumes, and propose a new classification system for describing fibroid uteri. 2. Reviewed the characteristics of a cohort of uterine fibroid subjects and perform a longitudinal analysis of MRgFUS results. 3. Assessed the fibroid volume treated, pain scores and cytokine levels and growth factor levels following MRgFUS and UAE. Results The Parallel Plannimetric method is an accurate and reliable method of measuring uterine, fibroid and non-perfused volumes. Classifying fibroid uteri by numbers of fibroids and the presence of dominant fibroids is useful for distinguishing between those cases to be treated by MRgFUS or UAE. Since the introduction of MRgFUS to our unit the percentage non-perfused volumes (NPV) achieved have increased from 41.22 to 50.49 (p=0.038), however the re-intervention rate at 5 years remains high at 50%. MRgFUS has an excellent safety record, and the introduction of the new ExAblate 2100 system also appears to be safe and well tolerated, with encouraging initial NPVs achieved. Following both MRgFUS and UAE circulating interleukin-6 (IL-6) is significantly raised, although this is not affected by the degree of pain experienced or the volume of fibroid treated. Following UAE there is rise in circulating vascular endothelial growth factor (VEGF) seen at one week, however no significant change in VEGF levels is seen following MRgFUS. These changes in VEGF are not related to fibroid volume. Discussion MRgFUS is a safe, well tolerated treatment for uterine fibroids, although re-intervention rate is high. Further developments in this treatment modality may continue to improve outcomes, however at present its routine use cannot be recommended.
Electrophysiological investigation of the mechanism of action of xenon on ion-channels and determination of the neuroprotective potential of xenon in an in vivo model of traumatic brain injury
Creators: name: Armstrong, Scott
Publisher: name: Imperial College London
Year: 2014

description: Xenon is a general anaesthetic gas with neuroprotective properties. Inhibition of the N-methyl-D-aspartate (NMDA) receptor glycine co-agonist site has been shown to mediate xenon neuroprotection against ischemic injury in vitro. Site-directed mutagenesis was used to produce point mutations in the GluN1 subunit of rat NMDA receptors. These were then expressed in HEK293 cells and the responses of mutant GluN1/GluN2A receptors to glycine and anaesthetics assessed using patch-clamp electrophysiology. Two mutations of the phenylalanine 758 site were found to eliminate xenon binding to the receptor without altering glycine affinity or the binding of sevoflurane and isoflurane. These selective mutations will allow for knock-in animals to be used to dissect the mechanism(s) underlying xenon neuroprotection and anaesthesia in vivo. The ability of the other noble gases (helium, neon, argon, and krypton) to influence two known molecular targets of xenon – the NMDA receptor and the TREK-1 channel – was also assessed using patch-clamp electrophysiology. These were found to have no influence on either NMDA receptors or TREK-1 channels. Finally, xenon’s neuroprotective efficacy against traumatic brain injury (TBI) in vivo was assessed using the rodent controlled cortical impact model of TBI. Focal contusion injury was administered to male C57 mice and animals administered either 75% xenon or control treatment for three hours. Xenon-treated animals performed better in functional tests and displayed favourable outcomes in brain histology, as compared to control animals. This data provides the first evidence of a neuroprotective effect for xenon against TBI in vivo.
Erhöhung der selbstständigen Entscheidungsfindung bei Tätigkeiten im beruflichen Alltag der Mitarbeitenden der reformierten Landeskirche Aargau durch die Wissensplattform «WikiRef»
Creators: name: Lückl-Pfister, Mirjam
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2019

description: Die vorliegende Bachelor Thesis beschäftigt sich mit der Entscheidungsfindung im beruflichen Kontext durch eine Onlinehilfe. Die Arbeit zeigt auf, unter welchen Rahmenbedingungen die Mitarbeitenden Entscheidungen treffen und wie die Entscheidungsfindung durch die Onlinehilfe gestärkt werden kann. Mit einer Kontextanalyse wurde der Nutzungskontext der Zielgruppen (namentlich ehrenamtlich Tätige als auch Mitarbeitende im Sekretariatswesen) untersucht. Im Anschluss folgte ein explorativer Usability-Test, um sowohl positive Aspekte als auch Probleme im Umgang mit der Onlinehilfe aufzuzeigen. In Folge wurden Nutzungsanforderungen an die Onlinehilfe abgeleitet. Es zeigte sich, dass die Nutzergruppe die Onlinehilfe als Werkzeug zur Entscheidungsfindung aktiv nutzt. Dies vor allem als Informationsplattform und zur Abklärung von Rechtsgrundlagen. Bei der Nutzung der Onlinehilfe zeigten sich einige Probleme bezüglich der Verständlichkeit der dargebotenen Inhalte und deren thematischen Gliederung. Mit einem Ampelsystem wurden die gefundenen Probleme priorisiert und konkrete Handlungsempfehlungen zur Optimierung der Onlinehilfe formuliert.
Additional file 1 of Clinical utility of FDG PET/CT for primary and recurrent papillary renal cell carcinoma
Creators: name: Hou, Guozhu
name: Zhao, Dachun
name: Jiang, Yuanyuan
name: Zhu, Zhaohui
name: Huo, Li
name: Li, Fang
name: Cheng, Wuying
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1.
title: Common Bottlenose Dolphin (Tursiops truncatus truncatus) Gillnet Bycatch Estimates Along the U.S. Mid-Atlantic Coast, 2014-2018
Creators: name: Lyssikatos, Marjorie C.
Publisher: name: Northeast Fisheries Science Center (U.S.)
Year: 2022

description: Northeast Fisheries Science Center reference document ; 22-02
On the relation between mental ability and speed of information processing in the Hick task: An analysis of behavioral and electrophysiological speed measures
Creators: name: Troche, Stefan J.
name: Merks, Sarah
name: Houlihan, Michael E.
name: Rammsayer, Thomas H.
Publisher: name: Elsevier
Year: 2017
Subjects: subject: 150 - Psychologie

description: Inspired by Robert Stelmack's research on the electrophysiological foundation of mental ability (MA), the present study investigated whether the well-established negative relation between reaction times (RTs) and MA in four conditions of the Hick task can be explained by faster stimulus classification and consolidation in working memory as measured by the P300 latency in the event-related potential. RTs of 113 female participants aged from 17 to 38 years increased with increasing number of response alternatives in the Hick task. Except for one condition, RTs were negatively and significantly related to MA but this relationship did not increase with task complexity. This pattern of results suggests that speed of response selection does not account for shorter RTs in individuals with higher than lower MA. Against our expectations, however, in none of the four conditions, P300 latency was related to MA. Thus, the negative association between RTs and MA cannot be explained in terms of faster stimulus evaluation and consolidation in working memory. As a tentative explanation of this lack of association, even the most complex condition was not demanding enough to require the inhibitory processes underlying the P300 component in a sufficient extent to reveal MA-related individual differences in P300 latency.
title: Erste Ergebnisse der ventralen Versiegelungstechnik mit Kollagenvlies für die chirurgische Therapie von Patienten mit Induratio penis plastica (IPP) und ventraler Penisverkrümmung
Creators: name: Sokolakis, I.
name: Hatzichristodoulou, G.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die ventrale Penisverkrümmung bei Induratio penis plastica (IPP) ist relativ selten, kann jedoch zu einer Unfähigkeit zum Geschlechtsverkehr führen, insbesondere in schweren Fällen mit Penisdeviation > 60°. Ventrale Krümmungen werden aufgrund der Gefahr[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Investigating the role of heme oxygenase and oxidative stress in oesophagogastric cancer
Creators: name: Priest, Oliver
Publisher: name: Imperial College London
Year: 2013

description: Background: Molecular mechanisms underlying gastric and oesophageal cancer include alterations in growth factors, cytokines and cell adhesion molecules. Heme oxygenase (HO) enzyme catalyses the degradation of heme and generates bilirubin and carbon monoxide that have antioxidant, anti-inflammatory and anti-apoptotic activities. HO enzyme is implicated in the biology of cancer by its effects on cell growth and resistance to apoptosis. The roles of HO-1 and HO-2 enzymes in cancer cell growth are poorly understood, with reports suggesting both anti-inflammatory, anti-tumour effects and tumour-protective mechanisms mediated by HO activity. The role of HO-2 in inflammation and cancer is largely unexplored. Further understanding the influence of the HO enzyme system may provide improved novel targets for oesophagogastric cancer therapy. Materials and Methods: The primary objective of the thesis was to characterise the role of the heme oxygenase pathway and modulation of HO activity in upper gastrointestinal cancer cell growth in vitro. Cell culture techniques included MTT growth assay, Western blotting protein analysis, pharmacological modulation of HO activity and targeted knockdown of HO mRNA. Apoptosis was studied with flow cytometry techniques. Enzymatic HO activity was measured by specific colorimetric assay. Results: Results showed that specific knockdown of HO-2 protein activity with induction of HO-1 enzyme caused a reduction in oesophageal and gastric cancer cell growth with cell cycle effects and an increase in apoptosis. Treatment with downstream products of HO activity carbon monoxide and bilirubin and the anti-inflammatory agent N-acetyl cysteine had similar effects and increased the response of cancer cells to chemotherapeutic agents. Conclusion: These studies further our understanding of the role of heme oxygenase in cancer, providing evidence that modification of HO activity in oesophagogastric cancer cells leads to reduced cell proliferation. The findings support future potential clinical applications of carbon monoxide therapy that require further experimental animal model and clinical studies in the context of oesophagogastric cancer.
Heterosexist attitudes amongst students entering a Bachelor of Social Work Programme in Switzerland: exploring continuing challenges for social work education
Creators: name: Gredig, Daniel
name: Bartelsen, Annabelle
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: subject: heterosexism
subject: heterosexist attitudes
subject: homophobia
subject: social work students
subject: Switzerland
subject: 300 - Sozialwissenschaften
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Social work programmes are expected to enable students to work adequately with sexual minorities. In Switzerland, however, curricular content on sexual minorities is lacking in BSW programmes. Potential sexual prejudice is not explicitly addressed. This study aimed to assess the attitudes towards lesbian women and gay men amongst students entering the BSW programme of a university in Switzerland to establish a basis for discussing curriculum development. Students entering the programme from 2015 through 2018 were surveyed using an online questionnaire. Heterosexist attitudes were captured using the ‘Multidimensional Scale of Attitudes toward Lesbians and Gay Men’. The responding 955 entering students reported positive attitudes towards lesbians and gay men and evidenced low levels of heterosexist views. However, only 4.3 per cent of the respondents consistently disagreed with all items expressing heterosexist views, whilst 43.3 per cent completely agreed with at least one item. The views expressed by male participants expressed significantly higher levels of heterosexism than did those of female participants. The findings evidence uncertainties and a lack of reflection on unquestioned but heteronormative views. This reflects a need to infuse BSW programmes with sexual minority content, to provide opportunities for critical reflection and to address heteronormative and heterosexist views.
Clinical care of HIV-patients: evaluating progress and future challenges
Creators: name: Smit, Mikaela
Publisher: name: Imperial College London
Year: 2014

description: Since the introduction of combination therapy in 1996, Human Immunodeficiency Virus (HIV) treatment has changed substantially. Over twenty new antiretroviral drugs have been licensed for the treatment of HIV-infection and HIV has been transformed into a long-term chronic infection for many patients. Yet it remains unclear how improved efficacy of new antiretrovirals reported in clinical trials has translated to population-level effectiveness in general clinical care. Nor is it clear how the increasingly chronic nature of HIV-infection, characterised by an ageing HIV-population increasingly suffering from age-related non-infectious co-morbidities and drug-drug interactions, will affect HIV care. Such an evaluation is important not just to measure progress, but also to address future challenges for clinical care in order to develop evidence-based changes to clinical guidelines and ensure continued high-quality care. By analysing a dataset that collects data from all HIV-infected patients in clinical care in the Netherlands it was shown that the use of combination antiretroviral therapy (cART) regimens in the Netherlands closely follows changes in guidelines, to the benefit of patients. While there was no significant improvement in mortality, newer drugs with better tolerability and simpler dosing resulted in improved immunological and virological recovery and reduced incidence of switching due to toxicity and virological failure. An individual-based model of the ageing HIV-population in the Netherlands was constructed and used to quantify and evaluate the future challenges posed by an ageing HIV-population. The model showed that the age-structure of HIV-patients in the Netherlands is rapidly shifting to older age. By 2030, almost three quarters of patients will be aged 50 or over. This will result in an increased burden of co-morbidity, polypharmacy and an increasing proportion of patients who will experience potential complications with their HIV-treatment. Cardiovascular disease (CVD) in particular will become a major burden of co-morbid disease. Integrating a smoking cessation programme or changing HIV-treatment guidelines to recommend prescribing a polypill for CVD to all HIV-patients aged 45 or 55 years and over could improve the burden of CVD, improve patient outcome and be cost saving in the long-term.
The role and regulation of FOXO3a in cancer and chemotherapy resistance
Creators: name: Gomes, Ana Rita
Publisher: name: Imperial College London
Year: 2011

description: Drug resistance is the major impediment to the success of cancer therapy. The PI3K/AKT pathway mediates a plethora of cellular functions, including cell survival, proliferation and differentiation. However, increased activation of this pathway has been correlated with drug resistance mechanisms. This pathway regulates the activity of FOXO transcription factors in a negative manner through AKT-dependent phosphorylations. The modulation of FOXO activity leads to a variety of cellular outputs, including cell cycle arrest and apoptosis that define this transcription factor as a tumour suppressor. Importantly, FOXO has also been shown to mediate the effect of many anti-cancer drugs, suggesting that it has an additional role in drug sensitivity and resistance. With this work, by studying the PI3K/AKT/FOXO axis in breast cancer, I have characterised its impact in drug sensitivity and resistance. I found that this axis is deregulated in breast cancer resistant cells. By extending my in vitro findings to clinical samples, I further elucidated the potential role of AKT and FOXO3a as indicators and predictors of treatment response in breast cancer. In addition, I have also characterised three novel downstream targets of FOXO3a - FOXP1, FOXM1 and VEGF – with important roles towards breast cancer progression and in the development of drug-resistance. By characterising these FOXO3a effectors, I unravelled a potential general mechanism by which FOXO3a represses gene target expression.
VDC / BIM bei der Gähler und Partner AG: Implementierung von ICE und modellbasierter Zusammenarbeit
Creators: name: Irmak, Engin
name: Jehle, Patrick
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: BIM
VDC
ICE-Session

description: Die Arbeit liefert theoretische sowie praktische Handhabungen zu ICE-Sessions. Wird ICE effizient eingesetzt, ist sie mehr als nur eine modellorientierte Koordinationssitzung. Innerhalb der ICE-Session sollen alle Fachplaner und Entscheidungsträger gemeinsam und zielorientiert Lösungen erarbeiten.
MRC Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for Medical Research Council (MRC) grant application data management plans.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the MRC and the University of Sheffield Library.
All applicants submitting funding proposals (research and fellowship grants) to the MRC must include a data Management Plan as an attachment to their application on Je-S. This includes applications for the renewal of existing funding. The DMP should comply with the MRC’s policy on research data sharing and should demonstrate how the PI will meet, or already meets, their responsibilities for research data quality, sharing and security. It should refer to any institutional and study data policies, systems and procedures and be regularly reviewed throughout the research cycle. It is advisable that all DMPs use the template to ensure consistency and make it easier to review (this is built into the DMPonline tool). For longitudinal studies, involving a series of data collections, the plan should be up to four A4 pages in length. For all other research, the plan should be no longer than three A4 pages.
For further information see the MRC policies and guidance accessible from the Data Sharing webpage, particularly Data Management Plans - Guidance for applicant, Data Management Plans - FAQs and guidance and the DMP Template.
The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan.
Development of a foot and ankle musculoskeletal model: implications for achilles tendinopathy
Creators: name: Weinert-Aplin, Robert
Publisher: name: Imperial College London
Year: 2014

description: This thesis investigates the mechanics behind Achilles tendinopathies and their respective treatments using a musculoskeletal modelling approach. Specifically, the eccentric heel-drop exercise used to treat Achilles tendinosis and orthotic heel wedges used to treat Achilles tendonitis were investigated, as the mechanics which drive tendon healing are not currently understood, but are believed to work by directly altering the mechanical loading of the Achilles tendon. An inverse dynamics model of the lower limb including the hip, knee ankle and MTP joints was developed to include a musculoskeletal foot and ankle model. An existing muscle geometry dataset was used, but a new algorithm to account for soft tissue and bony constraints at the ankle to ensure physiological musculo-tendon paths around the foot and ankle was developed. Optical motion, forceplate and instrumented pressure insole data was used to derive independent 3D ground reaction vectors necessary for the data inputs for each of the two foot segments modelled. In addition to the moments of the hip and knee, foot and ankle muscle forces and ankle joint reaction forces were also estimated. A cohort of 19 healthy individuals performed the eccentric heel-drop exercise used to treat Achilles tendinosis and walked on a level and up and down an inclined (10°) surface barefoot and in running shoes with and without prefabricated orthotic heel wedges used to treat Achilles tendonitis. Clinical questions regarding changes in lower limb mechanics due to variants of the eccentric heel-drop exercise and orthotic heel wedges were considered as well as model sensitivity to foot models and sources of centre of pressure (CoP) data. CoP data source and number of foot segments modelled did not consistently change the model outputs, with greater or worse similarity between sources depending on the specific phase of stance considered. An example of this are the reduced knee and hip extension moments and increased ankle dorsiflexion moments at heel-strike, but consistent peak ankle joint reaction and Achilles tendon forces due to different CoP inputs. Across all walking conditions, heel wedges were found to have minimal impact on Achilles tendon force, but had a significant impact on knee moments and secondary plantarflexors such as Tibialis Posterior and the toe flexor muscles. The ability of heel wedges to reduce Achilles tendon load during walking was not supported by this thesis. Key observations regarding the eccentric heel-drop exercise were the reductions in peak Achilles tendon force achieved when performing the exercise in running shoes compared to barefoot and with a flexed compared to extended knee. Given the increased difficulty in performing the flexed knee exercise, this questioned the efficacy of the flexed knee version of the task and possible changes to the rehabilitation protocol, incorporating the effect of shoes on peak Achilles tendon force were suggested.
NERC Annotated DMP Templates
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: These are annotated data management plan (DMP) templates for Natural Environment Research Council (NERC) Data Management Plans.
These documents (available in .pdf and .docx formats) were created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The documents include the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the NERC and the University of Sheffield Library.
The NERC Data Policy requires NERC-funded scientists to make their data openly available within two years of collection and deposit it in a NERC data centre for long term preservation. The aim is that all NERC-funded data are managed and made available for the long-term for anybody to use without any restrictions.
All NERC proposals require an Outline DMP to identify data sets of long term value that should be made available to NERC data centres for archiving and reuse at the end of the fellowship or grant. For successful proposals, the outline data management plans will be used by the NERC data centres to produce a full DMP in collaboration with the Principal Investigator(s), within three to six months of the start date of the grant.
Access the NERC outline and full DMP templates and guidance at: Data management planning. Please note that these are built into the DMPonline tool.
The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan.
Additional file 1 of The relationship between 2019-nCoV and psychological distress among parents of children with autism spectrum disorder
Creators: name: Wang, Luxi
name: Li, Dexin
name: Pan, Shixu
name: Zhai, Jinhe
name: Xia, Wei
name: Sun, Caihong
name: Zou, Mingyang
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Science Policy
Mental Health

description: Additional file 1: Appendix A. The psychological stress from COVID-19 questionnaire. Table S1. The variables’ values assigned in the regression analyses.
CXCR4 as a target for preclinical Positron Emission Tomography of cancer
Creators: name: Stevens, Elizabeth
Publisher: name: Imperial College London
Year: 2013

description: The chemoattractive interactions of the chemokine stromal derived factor-1 (SDF1) and its receptor CXCR4 play a key role in tumour metastasis, with CXCR4 expression found to be significantly higher in cancers with aggressive phenotypes. There is therefore an impetus for non-invasive means to sensitively identify tumours prone to progression. As such, the aim of this work was to develop a number of novel CXCR4 antagonists to assess their suitability as imaging radiotracers for positron emission tomography (PET). In this study, novel 14-mer peptide, pentapeptide and small molecular antagonists were designed, assessed for in vitro potency using radioligand binding and migration assays, and validated in vivo through imaging and biodistribution experiments. Several novel pentapeptide antagonists (CCIC7, CCIC15 and CCIC30) were found to inhibit CXCR4 function with moderate potency, although the radiolabelled tracers unfortunately showed poor localisation in vivo, due to rapid clearance or metabolism. Additionally, fluorophenylated derivatives of the small molecular antagonists It1t and AMD3465 were found to antagonise SDF1 binding and function at low concentrations, suggesting potential as CXCR4-targeting molecules. Finally, it was shown that a cation-chelated NO2A-conjugate derivative of the 14mer peptide TN14003 could antagonise CXCR4 at low concentrations, and furthermore that CXCR4-expressing tumours could be identified from non-expressing tumours by PET imaging with the use of a 68Ga-labelled derivative in CXCR4-dependent manner. The tracer accumulated in CXCR4-expressing tumours with a favourable signal-to-muscle ratio of 2.9, and was also found to show metabolic stability in plasma appropriate for PET imaging at 60 minutes. In conclusion, this study documents the successful validation of [68Ga]-CCIC16 for the identification of CXCR4-expressing tumours in vivo, and highlights several potential small molecular antagonist derivatives suitable for further investigation as PET tracers. While functionalisation of pentapeptide antagonists was generally unsuccessful, the report proposes further analysis and modifications that may potentially be used in future developments.
ESRC Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for Economic and Social Research Council (ESRC) grant application data management plans.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the UK Data Service and the University of Sheffield Library.
All ESRC grant applicants generating data during their research have to include a data management plan with their Je-S grant application. the data management plan helps decide how research data will be managed throughout the research cycle and how best to prepare for data deposit with the UK Data Service, so they may be archived and shared for future reuse. The ESRC DMP is organised into nine themes that applicants should address, which are built into the DMPonline ESRC template.
For further information see UK Data Service - Data management planning for ESRC researchers and ESRC Data management plan: guidance for peer reviewers.
The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan. Check the ESRC data sharing policy also.
Kooperationen im Modus des Müssens – Eine explorative Betrachtung zur Zusammenarbeit von Schulen mit außerschulischen Akteuren
Creators: name: Tulowitzki, Pierre
name: Ivanova-Chessex, Oxana
name: Wenger, Marco
Publisher: name: Waxmann
Year: 2019
Subjects: subject: Schule
subject: Kooperation
subject: Bildung
subject: Zwang
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Kooperationen zwischen Schulen und ausserschulischen Institutionen werden als ein wichtiges Element für die Entwicklung hin zu mehr Bildungsgerechtigkeit wie auch für eine ganzheitlichere Bildung verstanden. Allerdings sind die Erkenntnisse darüber, warum Schulen mit ausserschulischen Akteuren kooperieren, bisher begrenzt. Dieser Thematik widmet sich der vorliegende Beitrag, in dem rekonstruiert wird, in welche Zusammenhänge das schulische Kooperationshandeln eingebettet ist. Hierzu wurden in der Deutschschweiz qualitative Interviews mit Schulleitenden sowie Vertreter*innen kooperierender Institutionen durchgeführt. Die Ergebnisse deuten darauf hin, dass die Zusammenarbeit aus schulischer Sicht häufig im Modus des «Müssens» erfolgt.
title: Häufigkeit von Überbehandlungen bei symptomatischen Harnwegsinfektionen von Frauen im gebärfähigen Alter
Creators: name: Manseck, S.
name: Otto, W.
name: Schnabel, M. J.
name: Denzinger, S.
name: Burger, M.
name: Spachmann, P. J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Notfallambulanzen von großen Versorgungskrankenhäusern werden zunehmend von Patientinnen mit Harnwegsinfekten in Anspruch genommen. Aspekte der Sicherheitsmedizin mit der Sorge des Behandlers vor juristischen Konsequenzen einer konservativ ausgerichteten Therapie führen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
title: Data Stewardship Maturity Report for NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit-A (AMSU-A) Level 1c Brightness Temperature (TB), Version 1.0
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00301
Effects of obesity surgery on food preferences, taste and reward in animals and humans
Creators: name: Miras, Alexander Dimitri
Publisher: name: Imperial College London
Year: 2013

description: BACKGROUND: After Roux-en-Y gastric bypass bariatric surgery (RYGB) patients and animal models show a decreased preference for sweet/fatty foods. However, there are significant discrepancies in the findings of animal and human studies, and the mechanisms are not understood. AIMS: To investigate: 1. The effect of a high-fat (HFD) vs. low-fat (LFD) pre-operative maintenance diet on the ingestive behaviour of rats after RYGB 2. The effects of RYGB vs. gastric banding (BAND) surgery on food hedonics and brain reward systems in humans 3. The effects of RYGB on taste in humans METHODS: Study 1: Rats were fed either LFD or HFD before RYGB or sham surgery. Ingestive behaviour was assessed after surgery using food preference tests. Study 2: Brain reward responses to food were investigated using functional magnetic resonance imaging (fMRI), eating behaviour and metabolic phenotyping in body mass index (BMI) matched un-operated controls and patients after RYGB and BAND surgery. Study 3: The intensity and reward of sweet, fat and fat/sweet taste stimuli were assessed in patients undergoing RYGB using behavioural techniques. RESULTS: Study 1: Pre-operative maintenance diets with different fat contents, did not affect post-surgical weight loss or caloric intake. HFD-RYGB rats exhibited behaviour consistent with condition taste aversion to a familiar stimulus, compared to condition taste aversion to a novel stimulus in the LFD-RYGB rats. Study 2: Patients after RYGB had lower activation in brain reward systems to food and lower food hedonics than BAND patients and/or BMI-matched unoperated controls. Anorexigenic plasma gut hormones, plasma bile acids and dumping syndrome scores were higher in RYGB patients. Study 3: RYGB increased the intensity of fat/sweet taste solutions and reduced the reward value of fat/sweet stimuli. CONCLUSION: Pre-operative feeding may affect ingestive behaviour after RYGB. The mechanisms underlying the healthier food preferences after RYGB include the reduced reward value, and increased aversion to, high-calorie food and taste. Potential mediators are gut hormones, bile acids and altered gut nutrient sensing.
The structure characterization of hybrid from Enhancement of an organic–metallic hybrid charring agent on flame retardancy of ethylene-vinyl acetate copolymer.
Creators: name: Xu, Bo
name: Ma, Wen
name: Shao, Lushan
name: Qian, Lijun
name: Qiu, Yong
Publisher: name: The Royal Society
Year: 2019

description: An organic triazine charring agent hybrid with zinc oxide (OTCA@ZnO) was prepared and well characterized through Fourier transform infrared spectrometry (FTIR), solid-state nuclear magnetic resonance (SSNMR), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA). The flame retardancy and thermal behaviour of intumescent flame retardant ethylene-vinyl acetate (EVA) composites combining OTCA@ZnO and ammonium polyphosphate (APP) were investigated using limited oxygen index (LOI), UL-94 vertical burning, cone calorimetry and TGA. The structure and morphology of chars were investigated by scanning electron microscopy (SEM), FTIR, laser Raman spectroscopy analysis (LRS) and X-ray photoelectron spectroscopy (XPS). Results revealed that OTCA@ZnO exhibited excellent thermal stability and dispersity after hybridization. The flame retardancy and smoke suppression properties of EVA were significantly improved by introducing APP/OTCA@ZnO. TGA results indicated that APP/OTCA@ZnO presented an excellent synergistic effect and promoted the char formation of EVA composites. Residue analysis results showed more char with high quality connected by richer P–O–C, P–N and P–O–Si structures was formed in APP/OTCA@ZnO system than APP/HOTCA/ZnO system, which consequently suppressed more efficiently the combustion and smoke production due to the in situ catalytic carbonization effect of hybrid.
The Role of the NOS-ADMA-DDAH1 Pathway in Adipocytes and Obesity
Creators: name: Dowsett, Laura Bethany
Publisher: name: Imperial College London
Year: 2013

description: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS) which is metabolised by two isoforms of the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Inhibition of DDAH has been shown to increase ADMA concentrations both in vitro and in vivo. Clinically, high concentrations of ADMA have been associated with a range of diseases, particularly cardiovascular disease and more recently obesity. The role of the NO-ADMA-DDAH pathway has not yet been studied in adipose tissue. This thesis sets out to investigate the effects of pathological ADMA exposure firstly on adipocytes in vitro and secondly, on whole adipose physiology in vivo. In vitro the existence of the NO-ADMA-DDAH pathway was established in the 3T3-L1 cell line before investigating the effect of chronic ADMA exposure of their biology. ADMA was found to cause adipocyte hypertrophy through mTOR signalling in an NO independent manner. The effect of elevated ADMA on adipocytes in vivo was investigated through an adipocyte specific DDAH1 knockout. These mice developed visceral obesity with adipocyte hypertrophy with an increase in mTOR signalling. On a high fat diet there is a large increase in intracellular adipocyte ADMA in both knockout and control mice. Adipose vasculature is an important regulator of adipose expansion; to investigate the role of ADMA in this process an endothelial specific DDAH1 knockout mouse was developed. Angiogenesis in these mice is reduced restricting adipose growth in obesity. This thesis establishes that the NO-ADMA-DDAH1 pathway to be important in adipose physiology. Elevated ADMA in adipocytes and endothelial cells is detrimental to their function and increases various factors associated with the metabolic syndrome.
Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer
Creators: name: Ditzinger, Felix
name: Scherer, Uta Maria
name: Schönenberger, Monica
name: Holm, Rene
name: Kuentz, Martin
Publisher: name: American Chemical Society
Year: 2019
Subjects: poorly water-soluble drug
hot melt extrusion
polymeric modification

description: Hot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable amorphous solid dispersions (ASD). Considerations of miscibility, stability, and biopharmaceutical performance narrow the selection of excipients, and further technical constraints arise from needed pharmaceutical processing. The present work introduces the concept of molecularly targeted interactions of a coformer with a polymer to design a new matrix for HME. Model systems of dimethylaminoethyl methacrylate copolymer, Eudragit E (EE), and bicarboxylic acids were studied, and pronounced molecular interactions were demonstrated by 1H, 13C NMR, FTIR spectroscopy, as well as by different techniques of microscopic imaging. A difference was shown between new formulations exploiting specifically the targeted molecular interactions and a common drug−polymer formulation. More specifically, a modified matrix with Malic acid exhibited a technical extrusion advantage over polymer alone, and there was a benefit of improved physical stability revealed for the drug fenofibrate. This model compound displayed greatly enhanced dissolution kinetics from the ASD formulations. It can be concluded that harnessing molecularly designed polymer modifications by coformers has much potential in solid dispersion technology and in particular regarding HME processing.
Assured decison-making for autonomous systems
Creators: name: Bharadwaj, Sudarshanan
name: 0000-0003-3045-8584
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Formal methods
Urban air mobility
Robotics
AI

description: As autonomous systems become more widely used in society, they will necessarily have to make more decisions in order to meet increasingly complex objectives. However, to facilitate greater deployment of autonomous systems, especially in safety-critical contexts, it is crucial to provide guarantees that the decisions made by these systems will be safe and achieve the desired objective. This dissertation studies techniques for assuring decision-making in complex and large-scale autonomous systems. The dissertation uses synthesis techniques from the fields of formal methods to provide guarantees of correctness with respect to specifications provided in temporal logic. Synthesis methods often suffer from scalability issues limiting their applicability in realistic systems. To address this issue, the dissertation provides abstraction methods and decentralized synthesis architectures to provide guarantees in systems with partial-information as well as large numbers of interacting agents. The dissertation provides a systematic approach to assured decision-making in this dissertation that is agnostic to the specifics of the implementation details of the autonomous systems. Such an approach avoids having to assure systems case-by-case and will facilitate certification and deployment of autonomous systems in more application areas. Finally, the dissertation illustrates this concept in traffic management for urban air mobility operations and provide a synthesis architecture that can adapt to changing specifications or vehicle capabilities.
title: Data Stewardship Maturity Report for NOAA Climate Data Record (CDR) of AVHRR Daily and Monthly Aerosol Optical Thickness over Global Oceans, Version 3.0
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00297
Grobkostenschätzung ±10% in der Projektphase auf Basis von Kennzahlen
Creators: name: Meier, Marco
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: BIM
NPK

description: In dieser Projektarbeit werden Auswertungen von ausgeführten NPK Leistungsverzeichnissen im Rohbau beschrieben, die eine Grobkostenschätzung ±10% in der Projektphase ermöglichen. Diese Auswertungen beziehen sich hauptsächlich auf die NPKVerzeichnisse 241 Ortbetonbau, 314 Maurerarbeiten und 315 Vorgefertigte Betonelemente.
The Effects of Weight Cycling on Central Reward Signalling
Creators: name: Schofield, Sarah
Publisher: name: Imperial College London
Year: 2013

description: The increased prevalence of obesity in our society is a cause for serious concern. Although lifestyle and diet changes are successful ways to lose weight, a high percentage of people weight cycle, also known as “yoyo” dieting. Evidence suggests weight cycling is no more detrimental to a person’s health than remaining obese, but there still remains speculation over the mechanisms involved in weight regain. One such model proposes the “food addiction” model, whereby a deficit in reward function can lead to a blunted reward response to eating, leading to over consumption. In this thesis, I aim to clarify the role of mesolimbic dopamine signalling. Firstly, a short, medium and chronic high fat (HF) feeding study was used to assess the development of changes in dopamine signalling. Secondly, to assess the effects of a single weight cycle on dopamine signalling, mice were fed control or HF diets, and swapped diet every 6 weeks. Finally, to assess the effect of rapid weight change, lean and DIO mice swapped to a HF diet or control diet for a week, respectively. Chronic HF diet increased dopamine-related gene expression and showed a similar expression profile as short term HF feeding. Medium term HF feeding on the other hand showed a decrease in dopamine related gene expression. Weight cycling appeared to have no clear uniform effect on dopamine-related gene expression. Rapid weight gain showed little change in dopamine-related gene expression in the reward areas. Conversely, rapid weight loss induced a decrease in tyrosine hydroxylase (TH) and dopamine receptor 2 (D2R) mRNA in the VTA, but with little change elsewhere. In conclusion, my data does not support the “food addiction” model of changes in dopamine signalling contributing to obesity. Similarly, there appears to be little effect on dopamine gene expression with rapid changes in body weight.
Generic Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is a generic annotated data management plan (DMP) template for use in applications to funders other than RCUK, Wellcome Trust and Cancer Research UK. This may also be used when the funder does not require a data sharing plan to be submitted or for unfunded projects.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC) and the University of Sheffield Library.

Many research funders and organisations require DMPs, both during the bid-preparation stage and after funding has been secured. A DMP describes how you will collect, organise, manage, store, secure, backup, preserve, and where applicable, share your data. Each funder has slightly different guidelines and template structure, but the resulting DMP is generally expected to be two or three A4 pages in length.
For further guidance see the DCC webpages on Data management Plans and How to Develop a Data Management and Sharing Plan. Check your funder's data sharing policy also.