cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of a subset of human Natural Killer cells expressing high levels of Programmed Death 1: A phenotypic and functional characterization
Creators: name: Pesce, Silvia
name: Greppi, Marco
name: Tabellini, Giovanna
name: Rampinelli, Fabio
name: Parolini, Silvia
name: Olive, Daniel
name: Moretta, Lorenzo
name: Moretta, Alessandro
name: Marcenaro, Emanuela
Publisher: name: Firenze University Press
Year: 2017
Subjects: Natural Killer cells; programmed death receptor (PD-1); ovarian carcinoma; tumor escape; immune checkpoint; NK cell degranulation; NK cell proliferation; NK cell cytokine production; CD57+ NK cells; CMV

description: Background: PD-1 is an immunological checkpoint that limits immune responses by delivering potent inhibitory signals to T cells upon interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechanisms (1). Therapeutic PD-1 blockade has been shown to mediate tumor eradication with impressive clinical results. Little is known on the expression/function of PD-1 on human NK cells (2). Objective: To clarify whether human NK cells may express PD-1 and analyze their phenotypic/functional features. Methods: Multiparametric cytofluorimetric analysis of PD-1+ NK cells and their functional characterization by degranulation, cytokine production and proliferation assays. Results: We provide unequivocal evidence that PD-1 is highly expressed (PD-1bright) on a NK cell subset detectable in the peripheral blood of approximately one fourth of healthy individuals. These donors are always serologically positive for HCMV. PD-1 is expressed by CD56dim but not by CD56bright NK cells and is confined to fully mature NK cells characterized by the NKG2A-KIR+CD57+ phenotype. The proportions of PD-1bright NK cells were higher in the ascites of a cohort of ovarian-carcinoma patients suggesting their possible induction/expansion in tumor environments. Functional analysis revealed a reduced proliferative capability in response to cytokines, low degranulation and impaired cytokine production upon interaction with tumor targets. Conclusions: We have identified and characterized a novel subpopulation of human NK cells expressing high levels of PD-1. These cells have the phenotypic characteristics of fully mature NK cells and are increased in ovarian-carcinoma patients. They display low proliferative responses and impaired anti-tumor activity that can be partially restored by antibody-mediated disruption of PD-1/PD-L interaction.This work was supported by grants awarded by Associazione Italiana per la Ricerca sul Cancro- (AIRC-) Special Project 5x1000 no. 9962 and AIRC-IG 2014 Id. 15704 (Alessandro Moretta), AIRC-IG 2014 Id. 15283 (Lorenzo Moretta), Progetto di Ricerca di Ateneo 2014 (Emanuela Marcenaro) and Olive Daniel laboratory is supported by the Fondation pour la Recherche Médicale (Equipe FRM DEQ20140329534).
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
The isoprenoid end product N6-Isopentenyladenosine inhibits inflammation in bronchial epithelial cells through modulating the NFκB pathway
Creators: name: Santoro, Antonietta
name: Ciaglia, Elena
name: Bifulco, Maurizio
name: Nori, Stefania Lucia
Publisher: name: Firenze University Press
Year: 2017
Subjects: N6-isopentenyladenosine; inflammation; NF-κB

description: N6-Isopentenyladenosine (iPA) is a cytokinin identified in plants but also present in a free form or as a modified nucleoside bound to selenocysteine tRNA in human cells. It is an adenosine modified by an isopentenyl chain which derives from dimethylallil pyrophosphate (DMAPP), an intermediate of the mevalonate pathway. iPA is required for efficient translational decoding of selenoproteins, and can modulate a variety of biological processes including cell cycle progression, DNA synthesis and apoptosis (1). Recently, it has been shown that iPA can exhibit immunomodulatory and anti-inflammatory properties by activating NK cells and modulating cytokine production in a way depending on the concentration used (2). In order to further investigate the anti-inflammatory properties of iPA and its possible mechanisms of action, we analyzed its ability to inhibit TNFα-induced inflammation, either in normal human bronchial epithelial cells or in a model of exacerbated inflammation represented by bronchial cells derived from a Cystic Fibrosis (CF) patient bearing the ΔF508 mutation. Results showed that iPA inhibited IL-8 and RANTES release in both type of cells in a different manner. The analysis of the key enzymes of the STAT3 and NF-κB signalling pathways showed that iPA decreased the phosphorylation of STAT3 enzyme and markedly increased the expression of the direct NF-κB inhibitor, IκBα. These results were corroborated analyzing directly the NF-κB activity in HEK 293/T cells transfected with a NF-κB reporter plasmid. In these cells, iPA was also able to decrease IκBα levels. Of interest, we found that iPA also increased the expression of the antioxidant selenoprotein glutathione peroxidase only in CF cells. Altogether these data suggest that iPA can negatively regulate inflammation with a general mechanism of action involving the inhibition of NF-κB pathway but also propose that, in the presence of an altered inflammatory response such as in CF disease, iPA might act by modulating expression and/or synthesis of glutathione peroxidase.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Langerhans cells and Toll Like Receptors: how do they act and react in an in vitro psoriatic microenvironment?
Creators: name: Donetti, Elena
name: Arnaboldi, Francesca
name: Cornaghi, Laura Brigida
name: Landoni, Federica
name: Baruffaldi Preis, Franz
name: Prignano, Francesca
Publisher: name: Firenze University Press
Year: 2017
Subjects: Human epidermis; transmission electron microscopy; cell proliferation; cell differentiation

description: Tumor Necrosis Factor (TNF)-α, interleukin (IL)-17, IL-22 and IL-23 are involved in the psoriasis pathogenesis and represent a strong proinflammatory stimulus. Both epidermal keratinocytes (KCs) and Langerhans cells (LCs) early respond promoting an early epidermal response [1, 2]. Human skin can count on the cellular response supported by LCs and on innate immunity through the expression of Toll-like Receptors (TLRs) [4]. We aimed at investigate whether the exposure of normal human skin to a combination of TNF-α, IL-17, IL-22, and IL-23 (cytokine mix) affected i) LCs immunophenotype, ii) expression of TLR2 and TLR9 and iii) KC proliferation. Human skin samples were obtained after plastic surgery (n = 5) and exposed to the cytokine mix in a Transwell system at air-liquid interface, with a parallel control group. Samples were harvested 24 and 48 hours after cytokine stimulation, processed in parallel for immunofluorescence or ultrastructural analysis. A decrease of cell proliferation was evident in samples exposed to cytokine mix for 24 hours and this phenomenon was more and more evident later. TLR2 immunopositivity progressively disappeared in the basal layer after cytokine mix exposure compared to the control group, while TLR9 expression was induced in scattered granular keratinocytes. By TEM, LCs showed an activated phenotype. In conclusion, these results suggest that, in a microenvironment mimicking the psoriatic plaque, epidermis early stimulates two important lines of defense, thus proposing that a therapeutic intervention in this direction can interfere with the formation/progression of the psoriatic plaque.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Hsp60 and interleukins expression in the skeletal muscle and its implications in exercise and cachexia
Creators: name: Barone, Rosario
name: Macaluso, Filippo
name: Sangiorgi, Claudia
name: D’Amico, Daniela
name: Gammazza, Antonella Marino
name: Campanella, Claudia
name: Cappello, Francesco
name: Zummo, Giovanni
name: Farina, Felicia
name: Di Felice, Valentina
Publisher: name: Firenze University Press
Year: 2017
Subjects: Colon carcinoma; metastasis; cachexia; Hsp60; interleukin-6

description: Heat shock protein 60 (Hsp60) is a chaperon localizing in skeletal muscle mitochondria, whose role is poorly understood. This chaperone has been found also in other cellular localizations. In the three years we studied the levels of Hsp60 in fibres of the entire posterior group of hindlimb muscles (gastrocnemius, soleus, and plantaris) in mice after completing a 6-week endurance training program. In this evaluation we correlated Hsp60 levels with the expression of four isoforms of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α). Moreover, the short-term overexpression of hsp60, achieved by in vitro plasmid transfection was performed to determine whether this chaperon could have a role in the activation of the expression levels of PGC-1α isoforms. The levels of Hsp60 protein were fibre-type specific in the posterior muscles and endurance training increased its content in type I muscle fibers. Concomitantly with the increased levels of Hsp60 released in the blood stream of trained mice, mitochondrial copy number and the expression of three isoforms of PGC-1α increased. Overexpressing hsp60 in cultured myoblasts induced only the expression of PGC-1 α1, suggesting a correlation between Hsp60 overexpression and PGC-1 α1 activation. We are now studying the expression of Hsp60 in the muscles of trained and untrained C26-bearing mice, to understand if Hsp60 over expression may improve muscle performance and reduce cachexia. Four different interleukins have been also studied in cachectic mice, to understand which can be the effect of them on Hsp60 expression both in the tumor mass and the trained muscle.This work was funded by PRIN2009 - Prof. G. Zummo and PRIN2012 - Prof. Farina F.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Additional file 4 of Point-of-care testing and antibiotics prescribing in out-of-hours general practice: a register-based study in Denmark
Creators: name: Christensen, Line Due
name: Vestergaard, Claus Høstrup
name: Keizer, Ellen
name: Bech, Bodil Hammer
name: Bro, Flemming
name: Christensen, Morten Bondo
name: Huibers, Linda
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Figure A2. Relative antibiotic prescribing rate for different levels of GP’s tendency to use POC testing (PUT), stratified by type of POC test and GP sex. Fully adjusted binomial regression (relative rate, 95% confidence interval).
title: Bulgariens Transformationskrise und der lange Weg in die Europäische Union
Creators: name: Nikolov, Alexander
Year: 2008

description: Das Kernelement der vorliegenden Arbeit ist eine Analyse der Attraktivität des Wirtschaftsstandortes Bulgariens für ausländische Investoren. Da politische und wirtschaftliche Faktoren einen besonderen Einfluss auf die Entwicklung eines Landes haben, setzen sich zwei der vier Hauptteile mit dieser Thematik auseinander. Zu Beginn wird ein ausführlicher Überblick über die Politik Bulgariens während des Sozialismus, der postkommunistischen Zeit und der Annäherungsphase zum westlichen System unter besonderer Betrachtung des Beitritts Bulgariens zur Europäischen Union gegeben. Die einzelnen Übergangsphasen werden ausführlich erläutert und mit grafischen Illustrationen veranschaulicht. Der Wandel der bulgarischen Wirtschaft vom System der Planwirtschaft zu einer marktorientierten Wirtschaftsform wird unter Bedachtnahme des politischen Hintergrundes zum jeweiligen Zeitabschnitt ausführlich behandelt. Besonderes Augenmerk wird auf die Transformationsjahre gelegt. Das Verständnis für den politischen und wirtschaftlichen Entwicklungsprozess Bulgariens dient als Grundlage für die Untersuchung der Attraktivität des Wirtschaftsstandorts für ausländische Investoren. Neben der Erläuterung theoretischer Grundlagen wird auch das Investitionsklima analysiert, welches Auskunft über aktuelle Parameter der bulgarischen Volkswirtschaft gibt. Die anschließende Analyse der ausländischen Direktinvestitionen in Bulgarien in Verbindung mit deren Auswirkung und Bedeutung für das Land werden eingehend beobachtet. Zum Abschluss werden die gewonnen Erkenntnisse auf die Entwicklungen am bulgarischen Immobilienmarkt übertragen. Die Aktivitäten des Immobiliensektors während der bereits erwähnten Zeitabschnitte werden unabhängig von einander betrachtet. Der Leser soll dadurch einen besseren Überblick über den Fortschritt des bulgarischen Immobilienmarktes erhalten.
Spin orbit torque controlled stochastic oscillators with synchronization and frequency tunability
Creators: name: Debashis, Punyashloka
name: Maskay, Aman K.
name: Upadhyaya, Pramey
name: Chen, Zhihong
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Stochastic oscillators based on emerging nanodevices are attractive because of their ultra-low power requirement and ability to exhibit stochastic resonance, a phenomenon where synchronization to weak input signals is enabled due to ambient noise. In this work, a low barrier nanomagnet based stochastic oscillator is demonstrated, whose output jumps spontaneously between two states by harnessing the ambient thermal noise, requiring no additional power. Utilizing spin orbit torque in a three terminal device configuration, phase synchronization of these oscillators to weak periodic drives of particular frequencies is demonstrated. Experiments are performed to show the tunability of this synchronization frequency by controlling an electrical feedback parameter. The current required for synchronization is more than 8 times smaller than that required for deterministic switching of similar nanomagnetic devices. A model based on Kramers' transition rate in a symmetric double well potential is adopted and dynamical simulations are performed to explain the experimental results.
Additional file 5 of Point-of-care testing and antibiotics prescribing in out-of-hours general practice: a register-based study in Denmark
Creators: name: Christensen, Line Due
name: Vestergaard, Claus Høstrup
name: Keizer, Ellen
name: Bech, Bodil Hammer
name: Bro, Flemming
name: Christensen, Morten Bondo
name: Huibers, Linda
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Figure A3. Relative antibiotic prescribing rate for different levels of GP’s tendency to use POC testing (PUT), stratified by type of POC test and GP age. Fully adjusted binomial regressions (relative rate, 95% confidence interval).
Die and mould production: die extrusion behaviour of Ti-10V-2Fe-3Al alloy
Creators: name: Al-Salihi, Huda Akram
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Present study aims is to correlate the microstructural evolution with mechanical flow behaviour for Ti-10V-2Fe-3Al alloy during plastic deformation processes, in order to maintain the desirable microstructure without damage occurrence. Deformation behavior for Ti-10V-2Fe-3Al alloy during elevated temperature compression, tension and extrusion process was examined. Hot compression data at temperatures above and below, as well as at transus temperature (800°C) was examined at three strain rates. The key outcomes are summarized as follow: 1- A reliable phenomenological equation for Ti-10V-2Fe-3Al alloy was developed based on the hyperbolic-sine law to describe the flow stress dependence on the temperature and strain rate during plastic deformation. This phenomenological equation was effectively implemented in the FEM DEFORM2D software to predict damage evolution for Ti-10V-2Fe-3Al alloy during hot compression test. 2- The critical conditions for the initiation of dynamic recrystallization were mathematically determined at deformation temperatures 800°C, 810°C, 850°C and 870°C. 3- Optimize processing parameters by designing processing map for Ti-10V-2Fe-3Al alloy based on the variation of the power dissipation efficiency and instability criteria. The optimum region with higher power efficiency was observed at temperature range (760°C~795°C) and strain rate range (0.01 s-1 ~0.16 s-1). However, the instability region was clearly observed at 760°C and higher strain rate 1s-1, due to the formation of adiabatic shear bands. Extrusion process was carried out at 1000°C and 1100°C and extrusion ratio 8:1 on the samples that had been solution treated at 760°C and 900°C. Dynamic recovery, dynamic recrystallization, abnormal grain growth and surface cracks that might occur during extrusion, were critically identified. It was found that the billet sample that extruded at 1100°C (larger grain size) exhibited abnormal grain growth (in some regions). Further, recrystallized grains were clearly observed in both extrusion temperatures especially in the deformation zone. Simulation results showed that the extrusion temperature and speed are independent variables, and that the material at the centre of the billet does not suffer damage, but beyond a critical radius, damage increases significantly. Critical fracture criteria for Ti-10V-2Fe-3Al alloy based on Cockcroft - Latham were obtained from the hot tensile tests at 760°C 800°C and 870°C and strain rates 0.01s-1, 0.1s-1 and 1 s-1. It was found that the damage value increases as the temperature decreased and strain rate increased.
Sex, Love, and Black Lives
Creators: name: Curry, Mack
Publisher: name: Old Dominion University Libraries
Year: 2016

description: The title of my thesis is Sex, Love, and Black Lives. This title embodies the three prominent aspects of my life: intimacy, relationships, and being black in America. These subjects are important to me because they influence a lot of my writing. They have also made played a key role in shaping me into the person I am today. Section one will focus on my sexual experiences, section two will focus on romantic and platonic relationships I’ve had, and section three will focus on my perspective of being black in America.

Writing about my various thoughts and opinions allowed me to express myself in a way that I did not do with my parents. Writing about my sexual experiences also allows me to reflect on how each respective encounter has impacted emotionally. I like to write about sex in relation to love because I have had trouble connecting the two.

I also use my poems to elaborate on certain actions and thoughts that occur when I’m with a significant other. Writing a stanza or two here and there helps me to verbalize my feelings, filter them, and effectively communicate them when the time comes.

After sex and relationships will come a section on being black in America. Sensitive as this topic may be, it is one that needs to be addressed. With everything going on in the media about hate crimes and police brutality toward African Americans, I felt that the view of the 21st century young black male needs to be expressed.
title: Interspecies America
title: animal lives and reproductive politics at the Smithsonian National Zoo, 1887 - 1983
titleType: Subtitle
Creators: name: Dongilli, Dominic Addison
Publisher: name: University of Iowa
Year: 2027
Subjects: animal
animal studies
interspecies
queer studies
Smithsonian National Zoo
zoo
Sexuality

description: Iconic interspecies encounters define environmental and American cultures within the Smithsonian National Zoo. The legacies of the Zoo’s animal life extend beyond its representation and historical infrastructures, yet scholarly analysis of zoos as cultural institutions has neglected embodied interspecies relationships between humans and non-humans. This project brings American studies and the environmental humanities into conversation with queer theory and animal studies to challenge the two-dimensional narratives of institutional progress and the civic impact of zoos. I analyze the zoo as a twentieth century knowledge institution that generates and genders the work of zookeeping, the reproductive politics of conservation, and individual histories of animals. In contrast to most scholarship on the zoo that emphasizes it as alternately a space of leisure or cruel containment, “Interspecies America” engages the zoo as a powerfully contradictory site of cultural, scientific, and market production. I argue that zoos mediate US identities, cultures, and environmental futures where human and non-human animal bodies navigate the complex networks of nature and nation. I use three interspecies encounters as cases studies to frame my account of zoos as important mediators of American identities, cultures, and vitality: the Manifest Masculinity of William Temple Hornaday’s bison conservation in 1887; the gendered lives of “zoo wives” Lucile Quarry Mann, Elizabeth Crandall Reed, and the white tiger Mohini in the mid-20th century; and the techno-scientific reproductive management of giant pandas Ling-Ling and Hsing-Hsing during the Cold War era. Across these cases, individual zookeepers and directors became intimately involved in animal husbandry and breeding; attuned in contradictory ways to animals’ needs and potential as capital for zoos, themselves. In doing so, zoo exhibits become participatory spaces of knowledge creation, as human and non-human animal bodies interact, collide, and even attempt to avoid each other—often in ways that are ideologically skewed and which limit more ethical conceptions of life across species lines.
title: Additional bending moment for shear-lag phenomenon in tube structures
Creators: name: Lee, Kangkun
name: Lee, Kijang
Publisher: name: Bauhaus-Universität Weimar
Year: 2004
Subjects: subject: Finite-Elemente-Methode
subject: Physikalisches Verfahren
subject: Hochhaus
subject: 620

description: Framed-tube system with multiple internal tubes is analysed using an orthotropic box beam analogy approach in which each tube is individually modelled by a box beam that accounts for the flexural and shear deformations, as well as the shear-lag effects. A simple numerical modeling technique is proposed for estimating the shear-lag phenomenon in tube structures with multiple internal tubes. The proposed method idealizes the framed-tube structures with multiple internal tubes as equivalent multiple tubes, each composed of four equivalent orthotropic plate panels. The numerical analysis is based on the minimum potential energy principle in conjunction with the variational approach. The shear-lag phenomenon of such structures is studied taking into account the additional bending moments in the tubes. A detailed work is carried out through the numerical analysis of the additional bending moment. The moment factor is further introduced to identify the shear lag phenomenon along with the additional moment.
description: X. International Conference on Computing in Civil and Building Engineering: proceedings ; [ICCCBE], Weimar, June 02-04, 2004, vol. 2004
EPortfolios, Google Drive, and Cognitive Process Theory
Creators: name: Carl, Sarah Elizabeth
Publisher: name: Old Dominion University Libraries
Year: 2016

description: ePortfolios have gained popularity in higher education to document learning, assessing, and career showcasing. This thesis discusses how ePortfolios can be used in first-year writing classrooms to show writing processes using Google Drive, a non-ePortfolio platform and its connection to Linda Flower and John Hayes’ cognitive process theory. The thesis shows how a professor could use Google Drive as an ePortfolio platform through assignments.
Mechanical Properties of Au Coated Si Nanowafer: an Atomistic Study
Creators: name: Nahian, Shahriar
name: Nahid, Shahriar Muhammad
name: Motalab, Mohammad
name: Bose, Pritom
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Combined gold and silicon nano-system has spurred tremendous interest in the scientific community due to its application in different metal-semiconductor electronic devices and solar driven water splitting cells. Silicon, fabricated on gold layer, is prone to gold atom diffusion at its surface. In this study, detailed analysis of mechanical properties of gold coated silicon nanowafer is studied by performing molecular dynamics tensile and compressive simulations. The effects of temperature, gold coating thickness, strain rate and crystallographic orientation of silicon on the mechanical properties are observed for the nanowafer. It is found that both the ultimate tensile and compressive strength show inverse relationship with temperature. The nanowafer fails mainly by slipping along {110} plane due to excessive shear when loaded in [100] direction while a mixed slip and crack type failure occurs for 300K. Interesting crystallographic transformation from fcc to hcp crystal is observed in gold layer for the highest gold layer thickness during tension. The effects of strain rate in tension and compression is also studied. Finally, the crystal orientation of silicon is varied and the tension-compression asymmetry inn the gold coated silicon nanowafer is investigated. Reverse tension-compression asymmetry is observed in case of loading along [110] crystal orientation. The failure mechanism reveals that interesting crystal transformation of silicon occurs during compression leading to early yielding of the material.
description: 24 pages, 14 figures
Additional file 1 of Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla
Creators: name: Yin, Yangyang
name: Fu, Huanhuan
name: Mi, Fakai
name: Yang, Ye
name: Wang, Yaomin
name: Li, Zhe
name: He, Yihan
name: Yue, Zhenggang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Multiple sequences alignment of the conserved domain of WRKY transcription factors in G. macrophylla.
HSbooster.eu Final Event: Impact through Research, Innovation and Standards - Slides / Presentations
Creators: name: Ferguson, Nicholas
name: Mijatovic, Ivana
name: Boegh, Signe Annette
name: Giuffrida, Maria
name: Mocchio, Elena
Publisher: name: Zenodo
Year: 2025

description: On Wednesday 5 March 2025 (10:30-16:45 CET), HSbooster.eu held its final event in Brussels (Belgium) at Area 42.

Titled "Impact through Research, Innovation, and Standards," the event brought together key players in standardisation to explore how the HSbooster project has supported hundreds of EU-funded projects and beneficiaries in valorising their results by contributing to the creation or revision of standards.

Over seven dynamic sessions, experts, innovators, and policymakers shared success stories, lessons learned, and insights into the project’s legacy and future impact.

Learn more on the event page: https://hsbooster.eu/events/hsboostereu-final-event-impact-through-research-innovation-and-standards
Stability threshold for 2D shear flows of the Boussinesq system near Couette
Creators: name: Bian, Dongfen
name: Pu, Xueke
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we consider the stability threshold for the shear flows of the Boussinesq system in a domain $\mathbb{T} \times \mathbb{R}$. The main goal is to prove the nonlinear stability of the shear flow $(U^S,Θ^S)=((e^{νt\partial_{yy}}U(y),0)^{\top},αy)$ with $U(y)$ close to $y$ and $α\geq0$. We separate two cases: one is $α\geq 0$ small scaling with the viscosity coefficients and the case without smallness of $α$ and fixed heat diffusion coefficient. The novelty here is that we don't require $μ=ν$ and only need to assume that $μ$ is scaled with $ν$ or fixed, where $μ$ is the inverse of the Reynolds number and $ν$ is the heat diffusion coefficient.
2603425_Design of Experiment-Research Data for [Enhancing Engineering Education through a Combined Flipped Classroom].pdf
Creators: name: Khoa Trieu, Nguyen
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390113
subject: Science, technology and engineering curriculum and pedagogy

description: Research Data, [2603425_Design of Experiment-Research Data for [Enhancing Engineering Education through a Combined Flipped Classroom]], for [Enhancing Engineering Education through a Combined Flipped Classroom and Team-Based Learning Approach with Team Leaders] by [Nguyen and Truong] in [International Journal of Mechanical Engineering Education]
title: Der politische Bezirk Zwettl im Jahr 1945
Creators: name: Spannagl, Isolde Irmtraud
Year: 2008

description: Der politische Bezirk Zwettl im Jahr 1945 gibt einen Einblick in die politischen, wirtschaftlichen und sozialen Verhältnisse des letzten Kriegsjahres, aber auch einen Überblick über die Jahre 1938 bis 1945. Untersucht wurden hierfür in erster Linie Pfarr- und Schulchroniken des Bezirkes, aber auch persönliche Erinnerungen kamen zum Tragen. Das Jahr 1945 brachte für die Zivilbevölkerung dieser Region schwerste Belastungen durch die Besatzungsmacht.
Conformational impact on deformation of DNA TATA-box
Creators: name: Kanevska, P. P.
name: Volkov, S. N.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: The theoretical study of deformability of special sequence of DNA double helix TATA-box is presentated. The paper elaborates on the mechanisms of abnormal deformation of DNA TATA-box double helix that cannot be explained using the standard mechanical model of polymer molecules (WLC) and needs more detailed modeling. Analyzing of DNA TATA-box deformation it is shown the molucule can undergo significant deformations due to its property of the structural polymorphism, that is, possibility of the double helix fragment to exist in more then one conformations. In addition to elastic components (bending, twisting), the presented model includes the following deformation features: possibility of conformation rearrangement of the shapes of the sugar rings, effects of a specific nucleotide sequence and anisotropy, the coupling between components. Presented model allows describe abnormal deformation based on physical special fitures of double helix inner structure.
Additional file 2 of Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla
Creators: name: Yin, Yangyang
name: Fu, Huanhuan
name: Mi, Fakai
name: Yang, Ye
name: Wang, Yaomin
name: Li, Zhe
name: He, Yihan
name: Yue, Zhenggang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Phylogenetic tree of WRKYs from G. macrophylla and A. thaliana.
sj-pdf-1-imr-10.1177_03000605221119656 - Supplemental material for Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders
Creators: name: Kiran, Muniba
name: Ejaz, Samina
name: Iqbal, Muhamad Nouman
name: Malik, Waqas Nazir
name: Zahoor, Sana
name: Ejaz, Syeda Abida
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605221119656 for Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders by Muniba Kiran, Samina Ejaz, Muhamad Nouman Iqbal, Waqas Nazir Malik, Sana Zahoor and Syeda Abida Ejaz in Journal of International Medical Research
Additional file 3 of Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla
Creators: name: Yin, Yangyang
name: Fu, Huanhuan
name: Mi, Fakai
name: Yang, Ye
name: Wang, Yaomin
name: Li, Zhe
name: He, Yihan
name: Yue, Zhenggang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. The gene structure and the distribution of conserved motifs within each GmWRKYs in G. macrophylla.
PEDAGOGLARDA PROKRASTINATSIYASI SINDROMINING NAMOYON BO'LISHINING PSIXOLOGIK XUSUSIYATLARI
Creators: name: O'rozboyeva, Gulshanoy
Publisher: name: Zenodo
Year: 2024

description: Maqolada turli xil ta'riflar tahlili keltirilgan kechiktirish hodisasi, prokrastinatsiyaning o'ziga xos xususiyatlari (ogohlik, mantiqsizlik, salbiy oqibatlar va prokrastinatsiya bilan bog'liq salbiy tajribalar) muhokama qilinadi. Kechiktirishni o'rganishning zamonaviy yo'nalishlari ko'rib chiqiladi va ulardan eng rivojlangani kechiktirilgan vazifalarning xususiyatlarini va kechiktiruvchilarning individual va shaxsiy xususiyatlarini o'rganishdir. Oxirgi yo'nalishda prokrastinatsiya va nevrotizm, ekstraversiya, zehnlilik va boshqalar o'rtasidagi munosabatlarni o'rganish yanada istiqbolli hisoblanadi. Prokrastinatsiya fenomeni va shaxsiy xususiyatlar o'rtasidagi bog'liqlik bo'yicha keyingi empirik tadqiqotlar uchun gipotezalar ilgari suriladi.
Additional file 4 of Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla
Creators: name: Yin, Yangyang
name: Fu, Huanhuan
name: Mi, Fakai
name: Yang, Ye
name: Wang, Yaomin
name: Li, Zhe
name: He, Yihan
name: Yue, Zhenggang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S4. Chromatograms for the determination of four kinds of standards.
Ridge Regularized Estimation of VAR Models for Inference
Creators: name: Ballarin, Giovanni
Publisher: name: arXiv
Year: 2021
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Ridge regression is a popular method for dense least squares regularization. In this work, ridge regression is studied in the context of VAR model estimation and inference. The implications of anisotropic penalization are discussed and a comparison is made with Bayesian ridge-type estimators. The asymptotic distribution and the properties of cross-validation techniques are analyzed. Finally, the estimation of impulse response functions is evaluated with Monte Carlo simulations and ridge regression is compared with a number of similar and competing methods.
description: Included discussion of cross-validation
Kann man (intime) Lebensformen bewerten? Eine Reflexion im Anschluss an Jürgen Habermas und Rahel Jaeggi
Creators: name: Laux, Bernhard
Publisher: name: UB Tübingen
Year: 2017

description: In der Frage der Bewertbarkeit von Lebensformen scheint sich die unangenehme Alternative aufzutun, entweder in »ethischer Enthaltsamkeit« auf eine kritische Reflexion verzichten zu müssen oder eine partikulare ethische Setzung als Bezugspunkt auszuzeichnen – mit Gefahren bis hin zur »Sittendiktatur«. Unter Bezugnahme auf die zunächst als Gegenpositionen erscheinenden Ansätze von Habermas und Jaeggi wird versucht, ein differenzierteres Bild zu gewinnen. Die Analyse führt zum Ergebnis, dass Jaeggi eine ertragreiche Position zur Kritik von Lebensformen vorstellt, die aber ethisch selbst enthaltsam ist und eher moralisch grundiert erscheint. In mancherlei Hinsicht ist sie mit Habermas’ Ansatz verträglich und führt im Blick auf den politisch-rechtlichen Umgang mit Lebensformen zu ähnlichen Konsequenzen.

Regarding the assessability of different forms of life two unpleasant alternatives seem to emerge: Either to renounce from any kind of critical reflection as a form of ›ethical abstinence‹ or using particular cultural values as a reference – including risks up to a morality police as the worst case. With reference to the initially opposed positions of Habermas and Jaeggi it is attempet to draw a differentiated picture. The analyses results in the conclusion that Jaeggi introduces a fruitful position regarding the critics on different forms of life which in itself is ethically abstinent and appears to be morally grounded. In some aspects, it is compatible with Habermas’ approach and leads to similar consequences with respect to political and legal treatment of different forms of life.
description: Ethik und Gesellschaft, Nr. 1 (2017): Sozialethik der Lebensformen
Local expression of SOD1G93A mutant protein triggers neuromuscular junction dismantlement
Creators: name: Dobrowolny, Gabriella
name: Martini, Martina
name: Romanello, Vanina
name: Boncompagni, Simona
name: Pietrangelo, Laura
name: Bouchè, Marina
name: Rudolf, Rüdiger
name: Protasi, Feliciano
name: Sandri, Marco
name: Musarò, Antonio
Publisher: name: Firenze University Press
Year: 2017
Subjects: Oxidative stress; NMJ; aging; ALS; muscle

description: The alteration of Reactive Oxygen Species (ROS) homeostasis plays a causal role in several chronic pathology such as aging and neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS). Although it is recognized that axon and synapses are first cellular sites of degeneration in ALS disease, controversy exists on whether pathological events initially begin at the NMJs and then, in a dying back phenomena, contribute to motor neuron degeneration. Moreover, the precise molecular mechanisms of pathology-associated deterioration in neuromuscular system have remained elusive (1). Here we provide evidences that muscle specific accumulation of SOD1G93A in the transgenic mice model MLC/SOD1G93A (2) induces mitochondria dysfunction and triggers NMJ dismantlement. Further, we demonstrate that treatment of MLC/SOD1G93A mice with Trolox, a potent antioxidant, is sufficient to rescue mitochondria and NMJ defects in the MLC/SOD1G93A mice, stabilizing muscle-nerve connection. The analysis of potential molecular mechanisms that mediate the toxic activity of SOD1 revealed the activation of specific Protein Kinase as a downstream player of NMJ dismantlement. Overall our data demonstrate that muscle specific expression of SOD1G93A mutation causes mitochondrial impairment and NMJ dismantlement, suggesting that muscle defects and NMJs alteration precede motor neuron degeneration rather than resulting from it.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Additional file 12 of Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla
Creators: name: Yin, Yangyang
name: Fu, Huanhuan
name: Mi, Fakai
name: Yang, Ye
name: Wang, Yaomin
name: Li, Zhe
name: He, Yihan
name: Yue, Zhenggang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12: Table S8. The contents of four representative components (loganic acid, swertiamarin, gentiopicroside and swerosides) in different tissues.
Sarcoglycans and mucin in epithelial tissues of digestive and respiratory tracts: an immunofluorescence study
Creators: name: Rizzo, Giuseppina
name: Vermiglio, Giovanna
name: Favaloro, Angelo
name: Duca, Antonio
name: Migliorato, Alba
name: Spoto, Cecilia
name: Cutroneo, Giuseppina
Publisher: name: Firenze University Press
Year: 2017
Subjects: Mucins; sarcoglycans; epithelia; immunofluorescence

description: Sarcoglycans are transmembrane glycoproteins which play a key role in maintaining sarcolemma stabilization during muscle contraction. Several studies have demonstrated that this complex is not muscle specific and that it is also expressed in epithelial tissues as gingival, breast and prostatic epithelia. In the present study we investigated sarcoglycans expression in the epithelia of digestive and respiratory tracts. We performed immunofluorescence reactions using antibody against a-, b-, g-, d-, e- and z-sarcoglycans and against mucin 4 and 16. Mucins are a superfamily of proteins which serve to protect the underlying epithelia against a wide range of injuries (bacteria, virus, parasites, toxins, pH). This protection leads to coordinate cell proliferation, differentiation and apoptosis among other cellular responses; in fact, mucins are promising biomarkers and therapeutic targets in cancer and inflammatory diseases. Our results show the expression of sarcoglycans in the basal, lateral, and apical epithelial cell’s surface; moreover, sarcoglycans show to colocalize with mucins in the cell’s apical surface of bronchi and bronchioles, stomach and intestine but no apical localization has been detected in the esophageal epithelium. These results support the role of sarcoglycans in cell-cell and cell-matrix interaction. Moreover, the colocalization between sarcoglycans and mucins at apical level of epithelia which have high mucosecretory activity suggest that sarcoglycans could interact with mucus, maybe involving in maintainig omeostasis of gastro enteric epithelia. It will be necessary to demonstrate the hypothetical correlation between sarcoglycans and the maintaining epithelial homeostasis.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Isolation and characterization of extracellular vesicles secreted by pre-pubertal Sertoli cells
Creators: name: Luca, Giovanni
name: Falabella, Giulia
name: Calvitti, Mario
name: Giovagnoli, Stefano
name: Mancuso, Francesca
name: Arato, Iva
name: Lilli, Cinzia
name: Bellucci, Catia
name: Becchetti, Alessio
name: Antognelli, Cinzia
name: Bodo, Maria
name: Baroni, Tiziano
name: Calafiore, Riccardo
Publisher: name: Firenze University Press
Year: 2017
Subjects: Sertoli cells; extracellular vesicles

description: Recent studies have shown that extracellular vesicles (Ev) are an important mechanism of intercellular communication. In fact, Ev may contain proteins, DNA and mRNA. In particular, the latter play an important role in various biological processes including regulation and cell differentiation [1]. Sertoli cells (SC), previously considered as a mere “sustentacular cell”, were re-evalued in their functions and elevated to the rank of a “sentinel” in spermatogenesis due to production of trophic, differentiation and immune-modulators factors. Porcine pre-pubertal SC, isolated by our method [2], upon 48 hours culture, SC were stimulated with recombinant a-follitropin (rFSH) or FSH + testosterone (T) to evaluate both the presence in the medium of SC-derived Ev (SC-Ev) and SC-Ev content, in terms of mRNA for Anti-Müllerian hormone (AMH), inhibin B, Androgen Binding Protein (ABP) and FSH-receptor (FSH-r), by RT-PCR. SEM analysis highlighted the presence of SC-Nv in culture medium with mean diameters < 149 nm. We have also demonstrated, within the SC-Ev, significant increase in mRNA for AMH, ABP and FSH-r after both FSH and FSH+T stimulation, as compared to unstimulated SC-Ev. Differently from unstimulated SC-Ev, mRNA inhibin B levels were unchanged in FSH-stimulated SC-Ev, and increased after FSH+T stimulation. Interestingly, an opposite trend was shown in mRNA secretion, in control SC monolayer where, we demonstrated a decrease of AMH and FSH-r mRNA (after both stimulations with FSH or FSH + T) and an increase of inhibin B mRNA. On the contrary, mRNA ABP levels, in SC monolayer, decreased after stimulation with FSH but were unchanged in the presence of FSH+T. For the first time in the Literature, our work has shown the presence of SC-Nv containing AMH, inhibin B, ABP and FSH-r mRNA regulated by FSH with or without T. This result may suggest that other testicular cells could produce factors that, until now, were considered an exclusive SC secretory product.This work was supported by Mr.Gary Harlem (Altucell Inc. 3 Astor Court, Dix Hills, New York, NY) and Merck-Serono (London, UK).
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Pluralität der Lebensformen und Modelle theologischer Ethik
Creators: name: Scherzinger, Gregor
Publisher: name: UB Tübingen
Year: 2017

description: Gesellschaftliche Diskussionen um die Anerkennung unterschiedlicher Modelle des Zusammenlebens führen immer wieder klar vor Augen, durch welche Pluralität diese Gesellschaften charakterisiert sind. Die gesellschaftliche Vielfalt ist verbunden mit einem normativen, moralischen Pluralismus, weshalb gerade die theologisch-ethische Reflexion vor der Frage steht, mit welcher Methodik sie auf diese Realität reagiert. Es werden zwei solche Modelle skizziert, und diskutiert, wie in ihnen mit dem Phänomen des Pluralismus verfahren wird. Im Anschluss an die Kritik dieser Modelle wird eine Alternative beschrieben, die von der theologischen Ethik fordert bei den sozialen Praktiken und der ihnen immanenten Normativität anzusetzen. Lebensformen sind Bündel solcher Praktiken, folglich sollte eine kritische Diskussion mit der Frage ansetzen, als wie zweckmäßig sich unterschiedliche Lebensformen erweisen.
Debates in the public sphere on the recognition of diverse forms of communal life make plain how societies are characterized by a plurality. Since societal diversity is entangled with normative moral pluralism, the theological-ethical discourse needs to grapple with the question what method is suggested by this reality. Two models are outlined and discussed with a focus on how they deal with this pluralism. Thereafter, an alternative model is delineated which demands that any theological-ethical discussion begins with the social practices involved and draws on their immanent normativity. Forms of living depict clusters of such practices, which is why their critique must focus on whether these forms of living comply with the purposes implied by those practices.
description: Ethik und Gesellschaft, Nr. 1 (2017): Sozialethik der Lebensformen