Additional file 1 of Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW)
Creators: name: Berentschot, J. C.
name: Bek, L. M.
name: Heijenbrok-Kal, M. H.
name: van Bommel, J.
name: Ribbers, G. M.
name: Aerts, J. G. J. V.
name: Hellemons, M. E.
name: van den Berg-Emons, H. J. G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Additional file 1: Figure S1. Flowchart of COVID-19 patients that received post-discharge follow-up in the hospital. The first follow-up visit was generally scheduled around 6 weeks post-discharge. For patients with persistent residual pulmonary abnormalities, follow-up was continued around 3 months, 6 months, 1 year, and 2 years after hospital discharge. After each visit, patients with no or minimal residual pulmonary abnormalities were discharged from further follow-up. Pulmonary function test (PFT) comprised the assessment of spirometry and/or gas exchange. Figure S2. Forest plots presenting risk factors of A: fatigue, B: cognitive failures, C: sleep quality, and D: EQ-5D index value. Data are obtained using multivariable Generalized Estimating Equations analysis. Fatigue was assessed with the Fatigue Assessment Scale, the total FAS score ranges from 0 to 50 with higher scores representing more symptoms of fatigue. Cognitive failures were assessed with the Cognitive Failures Questionnaire, the total CFQ score ranges from 0 to 100 with higher scores representing more cognitive failures. Sleep quality was assessed with the Pittsburgh Sleep Quality Index, the total PSQI score ranges from 0 to 21 with higher scores representing poorer sleep quality. Health-related quality of life was assessed with the 5-level EuroQoL-5D questionnaire, a EQ-5D index value of 0 indicates death and 1 perfect health; negative scores indicate a health status worse than death. Adj β, Adjusted Beta; CI, Confidence Interval; ICU, Intensive Care Unit; LOS, Length Of Stay. Table S1. Trajectories of self-reported recovery and symptoms in ICU- and non-ICU-treated patients for COVID-19 up to 2 years after hospital discharge. Table S2. The severity of symptoms in COVID-19 patients at 2 years after hospital discharge. Table S3A. Categorical outcomes on the mMRC dyspnea scale, IFIS, and recovery status questionnaires in patients with COVID-19 up to 2 years after hospital discharge. Table S3B. Domain scores of the EQ-5D-5L and SF-36 questionnaires in patients with COVID-19 up to 2 years after hospital discharge. Table S4. Trajectories of mental health and physical function up to 2 years after hospitalization within ICU- and non-ICU-treated COVID-19 patients. Table S5. Outcomes of objectively assessed cognitive and physical function in COVID-19 patients up to 2 years after hospital discharge. Table S6. Pulmonary function testing and radiologic outcomes in the total cohort up to 2 years after hospitalization for COVID-19. Table S7. Pulmonary function testing and radiological outcomes in 55 patients with initial poor pulmonary recovery who continued follow-up up to 2 years after hospitalization for COVID-19