cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Automatic Evaluation of Myocardial Infarction from Delayed-Enhancement Cardiac MRI
Creators: name: Lalande, Alain
name: Meriaudeau, Fabrice
name: Ginhac, Dominique
name: Qayyum, Abdul
name: Khawla Brahim
name: Pommier, Thibaut
name: Couturier, Raphaël
name: Salomon, Michel
name: Perrot, Gilles
name: Zhihao Chen
Publisher: name: Zenodo
Year: 2020
Subjects: MICCAI Challenges
Biomedical Challenges
MICCAI
MRI
Heart
Myocardial infarction
Segmentation
Classification
Delayed-enhancement

description: This is the challenge design document for the "Automatic Evaluation of Myocardial Infarction from Delayed-Enhancement Cardiac MRI" Challenge, accepted for MICCAI 2020. One crucial parameter to evaluate the state of the heart after myocardial infarction (MI) is the viability of the myocardial segment, i.e. if the segment recovers its functionality upon revascularization. MRI performed several minutes after the injection of a contrast agent (delayed enhancement-MRI or DE-MRI) is a method of choice to evaluate the extent of MI, and by extension, to assess viable tissues after an injury (in conjunction with the thickening of the muscle evaluated from cine-MRI) [1]. The two main objectives of this challenge are first to classify normal and pathological cases from the clinical information with or without DE-MRI, and secondly to automatically detect the different relevant areas (the myocardial contours, the infarcted area and the permanent microvascular obstruction area (no-reflow area)) from a series of short-axis DE-MRI covering the left ventricle. The segmentation allows us to make a quantification of the MI, in absolute value (mm3) or percentage of the myocardium. The database consists of 150 exams (all from different patients) divided into 50 cases with normal MRI after injection of a contrast agent and 100 cases with myocardial infarction (and then with a hyperenhanced area on DE-MRI), whatever their inclusion in the cardiac emergency department. Along with MRI, clinical characteristics are provided to distinguish normal and pathological cases. The training set (100 cases) as a dedicated online website will be available mid-April. To participate to the challenge and get access to the datasets, the participant should create an account through this dedicated online evaluation website. Moreover, the participants will also be requested to submit a paper following the MICCAI format that describe the methodology. The submitted
 papers will be accepted after a deep proofreading. The segmentation contest will take place in July, then before the conference, and the global ranking will be based on geometrical and clinical metrics currently used in medical practices. The classification contest will happen during the conference, and the global ranking will correspond to the classification accuracy. References [1] Kim RJ et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and
 contractile function. Circulation 1999, 100(19):1992 – 2002.
Additional file 1 of A systematic review and functional bioinformatics analysis of genes associated with Crohn’s disease identify more than 120 related genes
Creators: name: Garza-Hernandez, Debora
name: Sepulveda-Villegas, Maricruz
name: Garcia-Pelaez, Jose
name: Aguirre-Gamboa, Raul
name: Lakatos, Peter L.
name: Estrada, Karol
name: Martinez-Vazquez, Manuel
name: Trevino, Victor
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. PRISMA checklist.
Supplement for Interoception, Homeostatic Emotions and Sympathovagal Balance
Creators: name: Strigo, Irina A.
name: Arthur D. (‘Bud’) Craig
Publisher: name: The Royal Society
Year: 2016
Subjects: Neuroscience

description: We briefly review the evidence for distinct neuroanatomical substrates that underlie interoception in humans, and we explain how they substantialize feelings from the body (in the insular cortex) that are conjoined with homeostatic motivations that guide adaptive behaviours (in the cingulate cortex). This hierarchical sensorimotor architecture coincides with the limbic cortical architecture that underlies emotions, and thus we regard interoceptive feelings and their conjoint motivations as homeostatic emotions. We describe how bivalent feelings, emotions and sympathovagal balance can be organized and regulated efficiently in the bicameral forebrain as asymmetric positive/negative, approach/avoidance and parasympathetic/sympathetic components. We provide original evidence supporting this organization from studies of cardiorespiratory vagal activity in monkeys and functional imaging studies in healthy humans showing activation modulated by paced breathing and passively viewed emotional images. The neuroanatomical architecture of interoception provides deep insight into the functional organization of all emotional feelings and behaviours in humans.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
Supplementary information on nociceptive stimulation, EEG recording and LEP analysis from Affective touch and attachment style modulate pain: a laser-evoked potentials study
Creators: name: Krahé, Charlotte
name: Drabek, Marianne
name: Paloyelis, Yannis
name: Fotopoulou, Aikaterini
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Affective touch and cutaneous pain are two sub-modalities of interoception with contrasting affective qualities (pleasantness/unpleasantness) and social meanings (care/harm), yet their direct relationship has not been investigated. In 50 women, taking into account individual attachment styles, we assessed the role of affective touch and particularly the contribution of the C tactile (CT) system in subjective and electrophysiological responses to noxious skin stimulation, namely N1 and N2-P2 laser-evoked potentials. When pleasant, slow (versus fast) touch was administered to the (non-CT-containing) palm of the hand, higher attachment anxiety predicted increased subjective pain ratings, in the same direction as changes in N2 amplitude. By contrast, when pleasant touch was administered to CT-containing skin of the arm, higher attachment anxiety predicted attenuated N1 and N2 amplitudes. Higher attachment avoidance predicted the opposite results. Thus, CT-based affective touch can modulate pain in early and late processing stages (N1 and N2 components), with the direction of effects depending on attachment style. Affective touch not involving the CT system seems to affect predominately the conscious perception of pain, possibly reflecting socio-cognitive factors further up the neurocognitive hierarchy. Affective touch may thus convey information about available social resources and gate pain responses depending on individual expectations of social support.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
The stress-buffering role of friendships in young people with childhood threat experiences: a preliminary report
Creators: name: König, Maximilian
name: Berhe, Oksana
name: Ioannidis, Konstantinos
name: Orellana, Sofia
name: Davidson, Eugenia
name: Kaser, Muzaffer
name: Moreno-López, Laura
name: van Harmelen, Anne-Laura
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Science Policy
Mental Health

description: Background: High-quality friendships have a positive impact on the mental health of young people with childhood adversity (CA). Social stress buffering, the phenomenon of a social partner attenuating acute stress responses, is a potential yet unexplored mechanism that may underlie this relationship. Objective: This study examined whether perceived friendship quality was related to better mental health and lower neural stress response in young people with CA. Method: A total of N = 102 young people (aged 16–26) with low to moderate CA were included in the study. We first investigated associations between friendship quality, mental health, and CA. In a representative subset (n = 62), we assessed neural stress responses using the Montreal Imaging Stress Task. In our sample, CA was best described along two dimensions resembling threat or deprivation like experiences. Hence, we investigated both cumulative and dimensional effects of CA. Results: We found no support for social thinning after CA, meaning that the severity of CA (cumulative or dimensional) did not differentially impact friendship quality. High-quality friendships, on the other hand, were strongly associated with better mental health. Furthermore, acute stress increased state anxiety and enhanced neural activity in five frontolimbic brain regions, including the left hippocampus. We found weak support that threat experiences interacted with friendship quality to predict left hippocampal reactivity to stress. However, this effect did not survive multiple comparison correction. Conclusion: The absence of social thinning in our sample may suggest that the risk of developing impoverished social networks is low for rather well-functioning young people with low to moderate CA. Regardless, our findings align with prior research, consistently showing a strong association between high-quality friendships and better mental health in young people with CA. Future research is needed to examine whether friendships aid neural stress responses in young people with childhood threat experiences. Young people with childhood adversity underwent acute stress induction, eliciting frontolimbic reactivity.High-quality friendships were strongly associated with better mental health.Weak support for friendship stress buffering did not survive multiple comparison correction. Young people with childhood adversity underwent acute stress induction, eliciting frontolimbic reactivity. High-quality friendships were strongly associated with better mental health. Weak support for friendship stress buffering did not survive multiple comparison correction.
Supplementary Tables from Affective touch and attachment style modulate pain: a laser-evoked potentials study
Creators: name: Krahé, Charlotte
name: Drabek, Marianne
name: Paloyelis, Yannis
name: Fotopoulou, Aikaterini
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Affective touch and cutaneous pain are two sub-modalities of interoception with contrasting affective qualities (pleasantness/unpleasantness) and social meanings (care/harm), yet their direct relationship has not been investigated. In 50 women, taking into account individual attachment styles, we assessed the role of affective touch and particularly the contribution of the C tactile (CT) system in subjective and electrophysiological responses to noxious skin stimulation, namely N1 and N2-P2 laser-evoked potentials. When pleasant, slow (versus fast) touch was administered to the (non-CT-containing) palm of the hand, higher attachment anxiety predicted increased subjective pain ratings, in the same direction as changes in N2 amplitude. By contrast, when pleasant touch was administered to CT-containing skin of the arm, higher attachment anxiety predicted attenuated N1 and N2 amplitudes. Higher attachment avoidance predicted the opposite results. Thus, CT-based affective touch can modulate pain in early and late processing stages (N1 and N2 components), with the direction of effects depending on attachment style. Affective touch not involving the CT system seems to affect predominately the conscious perception of pain, possibly reflecting socio-cognitive factors further up the neurocognitive hierarchy. Affective touch may thus convey information about available social resources and gate pain responses depending on individual expectations of social support.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
Dataset from Affective touch and attachment style modulate pain: a laser-evoked potentials study
Creators: name: Krahé, Charlotte
name: Drabek, Marianne
name: Paloyelis, Yannis
name: Fotopoulou, Aikaterini
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Affective touch and cutaneous pain are two sub-modalities of interoception with contrasting affective qualities (pleasantness/unpleasantness) and social meanings (care/harm), yet their direct relationship has not been investigated. In 50 women, taking into account individual attachment styles, we assessed the role of affective touch and particularly the contribution of the C tactile (CT) system in subjective and electrophysiological responses to noxious skin stimulation, namely N1 and N2-P2 laser-evoked potentials. When pleasant, slow (versus fast) touch was administered to the (non-CT-containing) palm of the hand, higher attachment anxiety predicted increased subjective pain ratings, in the same direction as changes in N2 amplitude. By contrast, when pleasant touch was administered to CT-containing skin of the arm, higher attachment anxiety predicted attenuated N1 and N2 amplitudes. Higher attachment avoidance predicted the opposite results. Thus, CT-based affective touch can modulate pain in early and late processing stages (N1 and N2 components), with the direction of effects depending on attachment style. Affective touch not involving the CT system seems to affect predominately the conscious perception of pain, possibly reflecting socio-cognitive factors further up the neurocognitive hierarchy. Affective touch may thus convey information about available social resources and gate pain responses depending on individual expectations of social support.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
Historic fishpond sites at Puttenham, with a provisional discussion of Surrey fishponds
Creators: name: Currie, Christopher K
Publisher: name: Archaeology Data Service
Year: 2004

description: Surrey Archaeological Collections, 90, 273-293
description: Recent fieldwork near Puttenham located a series of historic fishponds and the earthworks of former fishponds, which seem to have been part of a high concentration of such features in the area, possibly dating back to the early-thirteenth century. The article records these sites and compares them with further fishpond sites in Surrey located during other surveys undertaken by the author. A distinctive type of fishpond is identified as associated with former common land in Surrey. These are discussed in relation to the limited research undertaken to date.
Excavation at Borelli Yard, Farnham: the tile kiln
Creators: name: Riall, Nicholas J E
Publisher: name: Archaeology Data Service
Year: 2004

description: Surrey Archaeological Collections, 90, 295-336
description: The report describes the excavation in 1985--1986 of a roof tile kiln built with great brick, voussoirs and tile which is dated to 1200--1220. Products from the kiln have been identified in Farnham Castle and Bishop's Waltham Palace. The connections between the Borelli Yard kiln and those in Farnham Park and at Guildford Castle and Palace are explored. Important documentary evidence for tile production at Highclere (Hampshire) is examined to illustrate the organization and running of the roof tile industry. Reports include:
Excavations at Eden Walk II, Kingston: environmental reconstruction and prehistoric finds (TQ 180 692)
Creators: name: Serjeantson, Dale
name: Field, David J
name: Penn, John
name: Shipley, Marion
Publisher: name: Archaeology Data Service
Year: 2002

description: Surrey Archaeological Collections, 81, 71-90
description: Excavations in Kingston-upon-Thames town centre in 1977 produced further evidence of an ancient channel of the Thames, associated with occupation debris from the Neolithic to the Roman period. Environmental samples provided evidence of the changing river regime and the local environment. Also a mass of burnt flint, finds of Bronze Age, Iron Age and Roman pottery, worked flint, worked antler, human and animal bones were found. The possibility that layers of waterlogged vegetation encountered at the water table were accumulated and used by prehistoric people is discussed. In addition to the prehistoric finds, Romano-British pottery, building material and animal bones were recovered. There are details of radiocarbon dates obtained and references and summaries for the specialist reports contained on microfiche. These include `Sediments' and `Molluscs and diatoms' by J Penn (M53 & M57); `Prehistoric wood' by I Tyers (M58); `Prehistoric pottery' (M60), `Fired clay' (M63) and `Worked flint' (M64) by D Field; `Stone objects' by D Field & J Penn (M65); `Burnt flint' by D Field & D Serjeantson (M67); `Worked antler' by D Serjeantson (M69); `Human bones' by T Waldron & D Serjeantson (M71); `Prehistoric and Romano-British animal bones' by D Serjeantson (M73); `Romano-British pottery' and `Romano-British building material' (M79 & M80) by J Higson & S Degnan.
Additional file 1 of Transfer learning for medical image classification: a literature review
Creators: name: Kim, Hee E.
name: Cosa-Linan, Alejandro
name: Santhanam, Nandhini
name: Jannesari, Mahboubeh
name: Maros, Mate E.
name: Ganslandt, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1. Search terms.
Somatic symptom distress and ICD-11 prolonged grief in a large intercultural sample
Creators: name: Hennemann, Severin
name: Killikelly, Clare
name: Hyland, Philip
name: Maercker, Andreas
name: Witthöft, Michael
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Background: Grief is a multi-faceted experience including emotional, social, and physical reactions. Research in ICD-11 prolonged grief disorder (PGD) in different cultural contexts has revealed different or potentially missing grief symptoms that may be relevant. Objective: This study thus aimed to explore the prevalence of somatic symptom distress and its associations with grief and negative affect in a culturally diverse sample of bereaved individuals with symptoms of PGD. Methods: Based on cross-sectional survey data from the Measurement and Assessment of Grief (MAGIC) project, this study included 1337 participants (mean age 23.79 yrs, 76.1% female) from three regions (USA: 62.3%, Turkey/Iran: 24.2%, Cyprus/Greece: 13.5%), who experienced a loss of a significant other. Associations between somatic symptom distress (Somatic Symptom Scale, SSS-8), symptoms of PGD (International Prolonged Grief Disorder Scale, IPGDS-33), anxiety (Generalized Anxiety Disorder Questionnaire, GAD-7), depression (Patient Health Questionnaire, PHQ-9) as well as demographic and loss related characteristics were investigated. Three hundred and thirteen participants (23.4%) scored above the proposed cut-off for clinically severe PGD. Results: ‘High’ or ‘very high’ levels of somatic symptom distress were more frequent in a possible PGD group (58.2%), than in a non-PGD group (22.4%), p < .001, as divided per cut-off in the IPGDS. In a multiple regression analysis, PGD symptoms were significantly but weakly associated with somatic symptom distress (β = 0.08, p < .001) beyond demographics, loss-related variables, and negative affect. Negative affect (anxiety and depression) mediated the relationship of PGD symptoms with somatic symptom distress and the indirect effect explained 58% of the variance. Conclusions: High levels of somatic symptom distress can be observed in a substantial proportion of bereaved across cultures. Our findings suggest that PGD is related to somatic symptom distress partly and indirectly through facets of negative affect. 30.8% of bereaved adults showed ‘high’ or ‘very high’ levels of somatic symptom distress.Anxiety and depression partially mediate relationship of PGD symptoms with somatic symptom distress.Findings encourage practitioners to consider somatic symptom distress in psychotherapeutic treatment of PGD. 30.8% of bereaved adults showed ‘high’ or ‘very high’ levels of somatic symptom distress. Anxiety and depression partially mediate relationship of PGD symptoms with somatic symptom distress. Findings encourage practitioners to consider somatic symptom distress in psychotherapeutic treatment of PGD.
Additional file 2 of Transfer learning for medical image classification: a literature review
Creators: name: Kim, Hee E.
name: Cosa-Linan, Alejandro
name: Santhanam, Nandhini
name: Jannesari, Mahboubeh
name: Maros, Mate E.
name: Ganslandt, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 2. Summary table of studies.
Longcross barrow, Chertsey: a survey and discussion of its setting
Creators: name: Currie, Christopher K
Publisher: name: Archaeology Data Service
Year: 2004

description: Surrey Archaeological Collections, 90, 341-346
description: A mound believed to be a Bronze Age bowl barrow is discussed in relation to the surrounding landscape and local boundaries. A survey revealed what appeared to be an unpublished excavation trench.
Additional file 3 of Transfer learning for medical image classification: a literature review
Creators: name: Kim, Hee E.
name: Cosa-Linan, Alejandro
name: Santhanam, Nandhini
name: Jannesari, Mahboubeh
name: Maros, Mate E.
name: Ganslandt, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 3. Summary table of public medical datasets.
title: Improved regional-scale groundwater representation by the coupling of the mesoscale Hydrologic Model (mHM v5.7) to the groundwater model OpenGeoSys (OGS)
Creators: name: Jing, Miao
name: Heße, Falk
name: Kumar, Rohini
name: Wang, Wenqing
name: Fischer, Thomas
name: Walther, Marc
name: Zink, Matthias
name: Zech, Alraune
name: Samaniego, Luis
name: Kolditz, Olaf
name: Attinger, Sabine
Publisher: name: Universität Potsdam
Year: 2020

description: Most large-scale hydrologic models fall short in reproducing groundwater head dynamics and simulating transport process due to their oversimplified representation of groundwater flow. In this study, we aim to extend the applicability of the mesoscale Hydrologic Model (mHM v5.7) to subsurface hydrology by coupling it with the porous media simulator OpenGeoSys (OGS). The two models are one-way coupled through model interfaces GIS2FEM and RIV2FEM, by which the grid-based fluxes of groundwater recharge and the river-groundwater exchange generated by mHM are converted to fixed-flux boundary conditions of the groundwater model OGS. Specifically, the grid-based vertical reservoirs in mHM are completely preserved for the estimation of land-surface fluxes, while OGS acts as a plug-in to the original mHM modeling framework for groundwater flow and transport modeling. The applicability of the coupled model (mHM-OGS v1.0) is evaluated by a case study in the central European mesoscale river basin - Nagelstedt. Different time steps, i.e., daily in mHM and monthly in OGS, are used to account for fast surface flow and slow groundwater flow. Model calibration is conducted following a two-step procedure using discharge for mHM and long-term mean of groundwater head measurements for OGS. Based on the model summary statistics, namely the Nash-Sutcliffe model efficiency (NSE), the mean absolute error (MAE), and the interquartile range error (QRE), the coupled model is able to satisfactorily represent the dynamics of discharge and groundwater heads at several locations across the study basin. Our exemplary calculations show that the one-way coupled model can take advantage of the spatially explicit modeling capabilities of surface and groundwater hydrologic models and provide an adequate representation of the spatiotemporal behaviors of groundwater storage and heads, thus making it a valuable tool for addressing water resources and management problems.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 851
The Plants That Will Disappear First in a Crisis
Creators: name: Nicole, Apelian
Publisher: name: Zenodo
Year: 2024

description: Explore the essential solution for crisis preparedness with our exclusive "Plants That Will Disappear First in a Crisis" Medicinal Garden Kit. In times of uncertainty, the reliance on plants for both sustenance and medicinal purposes becomes paramount. However, certain plants are at risk of disappearing rapidly, making it crucial to cultivate them in your own backyard for guaranteed access.
Additional file 1 of Script concordance test acceptability and utility for assessing medical students’ clinical reasoning: a user’s survey and an institutional prospective evaluation of students’ scores
Creators: name: Kün-Darbois, Jean-Daniel
name: Annweiler, Cédric
name: Lerolle, Nicolas
name: Lebdai, Souhil
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary data 1. Example of SCT used in the study.
Archaeology in Surrey 2002
Creators: name: Howe, Tony
name: Jackson, Gary
name: Maloney, Catharine
Publisher: name: Archaeology Data Service
Year: 2004

description: Surrey Archaeological Collections, 90, 347-371
description: Documents chance finds and organised archaeological fieldwork undertaken in the county and parts of Greater London during the year. Notes are divided into sections for each District or Borough and therein ordered by national grid reference.
Supplementary methods and results from Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke
Creators: name: García-Cordero, Indira
name: Sedeño, Lucas
name: Fuente, Laura De La
name: Slachevsky, Andrea
name: Forno, Gonzalo
name: Klein, Francisco
name: Lillo, Patricia
name: Ferrari, Jessica
name: Rodriguez, Clara
name: Bustin, Julian
name: Torralva, Teresa
name: Baez, Sandra
name: Yoris, Adrian
name: Esteves, Sol
name: Melloni, Margherita
name: Salamone, Paula
name: Huepe, David
name: Manes, Facundo
name: García, Adolfo M.
name: Ibañez, Agustín
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke. Neural correlates of the three dimensions were examined through structural and functional resting-state imaging, and online measurements of the heart-evoked potential (HEP). The three patient groups presented deficits in interoceptive accuracy, associated with insular damage, connectivity alterations and abnormal HEP modulations. Interoceptive learning was differentially impaired in AD patients, evidencing a key role of memory networks in this skill. Interoceptive awareness results showed that bvFTD and AD patients overestimated their performance; this pattern was related to abnormalities in anterior regions and associated networks sub-serving metacognitive processes, and probably linked to well-established insight deficits in dementia. Our findings indicate how damage to specific hubs in a broad fronto-temporo-insular network differentially compromises interoceptive dimensions, and how such disturbances affect widespread connections beyond those critical hubs. This is the first study in which a multiple lesion model reveals fine-grained alterations of body sensing, offering new theoretical insights into neuroanatomical foundations of interoceptive dimensions.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
title: A distinct metabolic signature predictsdevelopment of fasting plasma glucose
Creators: name: Hische, Manuela
name: Larhlimi, Abdelhalim
name: Schwarz, Franziska
name: Fischer-Rosinský, Antje
name: Bobbert, Thomas
name: Assmann, Anke
name: Catchpole, Gareth S.
name: Pfeiffer, Andreas F. H.
name: Willmitzer, Lothar
name: Selbig, Joachim
name: Spranger, Joachim
Publisher: name: Universität Potsdam
Year: 2020

description: Background High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of impaired glucose metabolism and type 2 diabetes. However, the molecular basis of impaired glucose metabolism is so far insufficiently understood. The development of so called 'omics' approaches in the recent years promises to identify molecular markers and to further understand the molecular basis of impaired glucose metabolism and type 2 diabetes. Although univariate statistical approaches are often applied, we demonstrate here that the application of multivariate statistical approaches is highly recommended to fully capture the complexity of data gained using high-throughput methods. Methods We took blood plasma samples from 172 subjects who participated in the prospective Metabolic Syndrome Berlin Potsdam follow-up study (MESY-BEPO Follow-up). We analysed these samples using Gas Chromatography coupled with Mass Spectrometry (GC-MS), and measured 286 metabolites. Furthermore, fasting glucose levels were measured using standard methods at baseline, and after an average of six years. We did correlation analysis and built linear regression models as well as Random Forest regression models to identify metabolites that predict the development of fasting glucose in our cohort. Results We found a metabolic pattern consisting of nine metabolites that predicted fasting glucose development with an accuracy of 0.47 in tenfold cross-validation using Random Forest regression. We also showed that adding established risk markers did not improve the model accuracy. However, external validation is eventually desirable. Although not all metabolites belonging to the final pattern are identified yet, the pattern directs attention to amino acid metabolism, energy metabolism and redox homeostasis. Conclusions We demonstrate that metabolites identified using a high-throughput method (GC-MS) perform well in predicting the development of fasting plasma glucose over several years. Notably, not single, but a complex pattern of metabolites propels the prediction and therefore reflects the complexity of the underlying molecular mechanisms. This result could only be captured by application of multivariate statistical approaches. Therefore, we highly recommend the usage of statistical methods that seize the complexity of the information given by high-throughput methods.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 850
Additional file 2 of Script concordance test acceptability and utility for assessing medical students’ clinical reasoning: a user’s survey and an institutional prospective evaluation of students’ scores
Creators: name: Kün-Darbois, Jean-Daniel
name: Annweiler, Cédric
name: Lerolle, Nicolas
name: Lebdai, Souhil
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Supplementary data 2. Example of multiple choice questions (MCQ) that can be found in progressive clinical cases (PCC).
Two Sites in Betchworth, 1986: Excavations at Church Barn and in The Street
Creators: name: Williams, David W
Publisher: name: Archaeology Data Service
Year: 2002

description: Surrey Archaeological Collections, 81, 103-132
description: Excavations on the site of the seven-bay, seventeenth century Church Barn produced medieval timbers, a threshing floor and `A fragment of medieval louver' described by David Williams (125--6). Work at site two, The Street, hoped to locate cottages known to have been demolished in the nineteenth century. There are reports on the `Historical background' by Beryl Higgins (105--7), the `Church Barn' by Martin Higgins (108--9), `The pottery' by Phil Jones (122--5), `The ceramic smoking pipes' by David Higgins (126--8) and `The animal bone' by Geraldene Done (128--9). In addition at least three skeletons were found at Priest's Cottage and there is a report on the skeletal evidence from Tony Waldron (129--30).
Supplementary document for The divergence of thermalization rates driven by the competition between finite temperature and quantum coherence - 7120726.pdf
Creators: name: Wang, Yuqing
name: Liang, Libo
name: Zheng, Qinpei
name: Huang, Qi
name: Chen, Wenlan
name: Zhang, Jing
name: Chen, Xuzong
name: Hu, Jiazhong
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: supplement material for fig. 2 and fig. 3
Additional file 2 of Network analyses of Oppositional Defiant Disorder (ODD) symptoms in children
Creators: name: Gomez, Rapson
name: Stavropoulos, Vasileios
name: Gomez, Andre
name: Brown, Taylor
name: Watson, Shaun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2.
A medieval timber building at London Road, Wallington, Sutton
Creators: name: Howe, Elizabeth
Publisher: name: Archaeology Data Service
Year: 2005

description: Surrey Archaeological Collections, 91, 217-230
description: Excavations at the former Elmwood Playing Fields site at London Road, Wallington, revealed evidence of a thirteenth-century hall. The pottery assemblage from the site contributes to the understanding of pottery supply sources in north Surrey in the later-thirteenth century. Specialist reports include
title: Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations
Creators: name: Kleessen, Sabrina
name: Nikoloski, Zoran
Publisher: name: Universität Potsdam
Year: 2020

description: Background: Flux balance analysis (FBA) together with its extension, dynamic FBA, have proven instrumental for analyzing the robustness and dynamics of metabolic networks by employing only the stoichiometry of the included reactions coupled with adequately chosen objective function. In addition, under the assumption of minimization of metabolic adjustment, dynamic FBA has recently been employed to analyze the transition between metabolic states. Results: Here, we propose a suite of novel methods for analyzing the dynamics of (internally perturbed) metabolic networks and for quantifying their robustness with limited knowledge of kinetic parameters. Following the biochemically meaningful premise that metabolite concentrations exhibit smooth temporal changes, the proposed methods rely on minimizing the significant fluctuations of metabolic profiles to predict the time-resolved metabolic state, characterized by both fluxes and concentrations. By conducting a comparative analysis with a kinetic model of the Calvin-Benson cycle and a model of plant carbohydrate metabolism, we demonstrate that the principle of regulatory on/off minimization coupled with dynamic FBA can accurately predict the changes in metabolic states. Conclusions: Our methods outperform the existing dynamic FBA-based modeling alternatives, and could help in revealing the mechanisms for maintaining robustness of dynamic processes in metabolic networks over time.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 852
Structures and fluorescent properties of picolinato zinc(II) and cadmium(II) complexes based on tridentate and tetradentate benzimidazole ligands
Creators: name: Feng, Rui
name: Huang, Fang-Fang
name: Yuan, Jia-Li
name: Lu, Zheng
name: Fang, Tao
name: Nie, Feng-Mei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Five picolinato zinc(II) and cadmium(II) complexes, [Zn(ntb)(pic)]ClO4·CH3OH·2H2O (1), [Zn(bbma)(pic)]NO3·2CH3OH (2), [Cd(ntb)(pic)]ClO4·0.75CH3OH·H2O (3), [Cd2(bbma)2(pic)2](ClO4)2 (4), and [Cd2(bbp)(bbp-H)(pic)2(C2H5OH)]ClO4 (5), have been synthesized, where pic is the anion of picolinic acid, ntb is tris(2-benzimidazolylmethyl)amine, bbma is bis(benzimidazol-2-yl-methyl)amine, and bbp is 2,6-bis(benzimidazol-2-yl)pyridine. All the complexes were characterized by X-ray single-crystal diffraction, elemental analysis, IR, fluorescence spectroscopy, and thermal gravimetric analysis. 1–3 are mononuclear complexes in which picolinate adopts a N,O-chelating mode. 4 is a symmetrical dinuclear complex bridged by two anti-parallel picolinates in a N,O,O-coordination mode. 5 is also a dinuclear complex in which only one picolinate is a bridge. A 1-D double chain is formed by extensive H-bonds and π–π stacking in 1, while single zigzag chains are formed in 5. Complexes 2–4 all exhibit 63-hcb 2-D frameworks. They extend to form four-connected 66-dia 3-D topological nets for 2 and 4 and five-connected 46·64-bnn 3-D topological nets for 3. The five complexes show emission maxima in the blue region in the solid state.
Additional file 1 of Network analyses of Oppositional Defiant Disorder (ODD) symptoms in children
Creators: name: Gomez, Rapson
name: Stavropoulos, Vasileios
name: Gomez, Andre
name: Brown, Taylor
name: Watson, Shaun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Supplementary Material, Figures and Tables from Is the cardiac monitoring function related to the self in both the default-network and right anterior insula?
Creators: name: Babo-Rebelo, Mariana
name: Wolpert, Nicolai
name: Adam, Claude
name: Hasboun, Dominique
name: Tallon-Baudry, Catherine
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive ‘I’ and the introspective ‘Me’, in a whole-brain analysis of magnetoencephalography (MEG) data. Here we confirm and anatomically refine this result with intracranial recordings (iEEG). In two patients, we show a parametric modulation of neural responses to heartbeats by the self-relatedness of thoughts, at the single trial level. A region-of-interest analysis of the insula reveals that MEG responses to heartbeats in the rAI encode the ‘I’ self-dimension. The effect in rAI was weaker than in the DN and was replicated in iEEG data in one patient out of two. We propose that a common mechanism, the neural monitoring of cardiac signals, underlies the self in both the DN and rAI. This might reconcile studies on the self highlighting the DN, with studies on interoception focusing on the insula.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
Supplementary information for Gao et al. from Convergent evolution of ramified antennae in insect lineages from the Early Cretaceous of Northeastern China
Creators: name: Taiping Gao
name: Chungkun Shih
name: Labandeira, Conrad C.
name: Santiago-Blay, Jorge A.
name: Yunzhi Yao
name: Ren, Dong
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Antennae are important, insect sensory organs that are used principally for communication with other insects and detection of environmental cues. Some insects independently evolved ramified (branched) antennae, which house several types of sensilla for motion detection, sensing olfactory and chemical cues and determining humidity and temperature levels. Though ramified antennae are common in living insects, occasionally they are present in the Mesozoic fossil record. Here, we present the first caddisflies with ramified antennae, the earliest known fossil sawfly and scorpionfly also with ramified antennae from the mid-Lower Cretaceous Yixian Formation of Northeastern China, dated at 125 million years ago (Ma). These three insect taxa with ramified antennae among three unrelated lineages provide evidence for broad structural convergence that historically has been best demonstrated by features such as convergent mouthparts. In addition, ramified antennae in these Mid-Mesozoic lineages likely do not constitute a key innovation, as they are not associated with significantly increased diversification compared with closely related lineages lacking this trait, and nor are they ecologically isolated from numerous, co-occurring insect species with unmodified antennae.
A multi-period site at 15 High Street, Stanwell
Creators: name: Leary, Jim
Publisher: name: Archaeology Data Service
Year: 2005

description: Surrey Archaeological Collections, 91, 271-275
description: Archaeological investigations undertaken in 2002 in advance of construction at the rear of an existing building at 15 High Street, Stanwell, Borough of Spelthorne, revealed activity dating from the prehistoric to the post-medieval periods, including Late Bronze Age pits, medieval agricultural activity, and eighteenth- and nineteenth-century domestic activity.
Burmeister et al. Supplementary Material for Host Coevolution Alters the Adaptive Landscape of a Virus from Host coevolution alters the adaptive landscape of a virus
Creators: name: Alita R. Burmeister
name: Lenski, Richard E.
name: Meyer, Justin R.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The origin of new and complex structures and functions is fundamental for shaping the diversity of life. Such key innovations are rare because they require multiple interacting changes. We sought to understand how the adaptive landscape led to an innovation whereby bacteriophage λ evolved the new ability to exploit a receptor, OmpF, on Escherichia coli cells. Previous work showed that this ability evolved repeatedly, despite requiring four mutations in one virus gene. Here, we examine how this innovation evolved by studying six intermediate genotypes of λ isolated during independent transitions to exploit OmpF and comparing them to their ancestor. All six intermediates showed large increases in their adsorption rates on the ancestral host. Improvements in adsorption were offset, in large part, by the evolution of host resistance, which occurred by reduced expression of LamB, the usual receptor for λ. As a consequence of host coevolution, the adaptive landscape of the virus changed such that selection favouring four of the six virus intermediates became stronger after the host evolved resistance, thereby accelerating virus populations along the path to using the new OmpF receptor. This dependency of viral fitness on host genotype thus shows an important role for coevolution in the origin of the new viral function.
Additional file 1 of Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients
Creators: name: Prevel, Renaud
name: Enaud, Raphaël
name: Orieux, Arthur
name: Camino, Adrian
name: Berger, Patrick
name: Boyer, Alexandre
name: Delhaes, Laurence
name: Gruson, Didier
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Supplemental Figure 1. Non metric Bray-curtis analysis of β-diversity of the V3-V4 sequencing run. XXA, B, and C samples: gut bacteriobiota samples. GXX: lung bacteriobiota samples. BlancV3-V4: negative control. Mock: mock community. Supplemental Figure 2. Non metric Bray-curtis analysis of β-diversity of ITS2 sequencing run. XXA, B, and C samples: gut mycobiota samples. GXX: lung mycobiota samples. Blanc1 and blanc2: negative controls. Mock: mock community.
title: Re-inventing ancient human DNA
Creators: name: Knapp, Michael
name: Lalueza-Fox, Carles
name: Hofreiter, Michael
Publisher: name: Universität Potsdam
Year: 2020

description: For a long time, the analysis of ancient human DNA represented one of the most controversial disciplines in an already controversial field of research. Scepticism in this field was only matched by the long-lasting controversy over the authenticity of ancient pathogen DNA. This ambiguous view on ancient human DNA had a dichotomous root. On the one hand, the interest in ancient human DNA is great because such studies touch on the history and evolution of our own species. On the other hand, because these studies are dealing with samples from our own species, results are easily compromised by contamination of the experiments with modern human DNA, which is ubiquitous in the environment. Consequently, some of the most disputed studies published - apart maybe from early reports on million year old dinosaur or amber DNA - reported DNA analyses from human subfossil remains. However, the development of so-called next- or second-generation sequencing (SGS) in 2005 and the technological advances associated with it have generated new confidence in the genetic study of ancient human remains. The ability to sequence shorter DNA fragments than with PCR amplification coupled to traditional Sanger sequencing, along with very high sequencing throughput have both reduced the risk of sequencing modern contamination and provided tools to evaluate the authenticity of DNA sequence data. The field is now rapidly developing, providing unprecedented insights into the evolution of our own species and past human population dynamics as well as the evolution and history of human pathogens and epidemics. Here, we review how recent technological improvements have rapidly transformed ancient human DNA research from a highly controversial subject to a central component of modern anthropological research. We also discuss potential future directions of ancient human DNA research.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 853