cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Process, structural, and outcome quality indicators to support perioperative opioid stewardship: a rapid review
Creators: name: Thomas, C.
name: Ayres, M.
name: Pye, K.
name: Yassin, D.
name: Howell, S. J.
name: Alderson, S.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 3: Supplementary materials 3. Quality indicators and themes
Analysis of European and national policies and practices on research data management
Creators: name: Grecu, Mihai
name: Lupu, Viorica
name: Coșuleanu, Ion
name: Țurcan, Nelly
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science, open data, research data, research data management, national research data management policies

description: This deliverable was created to achieve the objectives of the project "Boosting engagement of the Republic of Moldova in Open Science: methodological and applied support". The deliverable analyzes various policies regarding open data with the objective of identifying certain suggestions of solutions applicable to the landscape of scientific data in the Republic of Moldova, but also to take into account the possible problems related to the specific context in which the scientific research is carried out in the Republic of Moldova.
Topological Materials: Weyl Semimetals
Creators: name: Yan, Binghai
name: Felser, Claudia
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Topological insulators and topological semimetals are both new classes of quantum materials, which are characterized by surface states induced by the topology of the bulk band structure. Topological Dirac or Weyl semimetals show linear dispersion round nodes, termed the Dirac or Weyl points, as the three-dimensional analogue of graphene. We review the basic concepts and compare these topological states of matter from the materials perspective with a special focus on Weyl semimetals. The TaAs family is the ideal materials class to introduce the signatures of Weyl points in a pedagogical way, from Fermi arcs to the chiral magneto-transport properties, followed by the hunting for the type-II Weyl semimetals in WTe2, MoTe2 and related compounds. Many materials are members of big families and topological properties can be tuned. As one example, we introduce the multifuntional topological materials, Heusler compounds, in which both topological insulators and magnetic Weyl semimetals can be found. Instead of a comprehensive review, this article is expected to serve as a helpful introduction and summary by taking a snapshot of the quickly expanding field.
description: 19 pages, 7 figures, an invited review article for Annual Review of Condensed Matter Physics
Imaging of prostate cancer: optimizing affinity to prostate specific membrane antigen by spacer modifications in a tumor spheroid model
Creators: name: Krishnan, Mena Asha
name: Pandit, Amit
name: Sharma, Rajesh
name: Chelvam, Venkatesh
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Early diagnosis of prostate cancer (PCa) is crucial for staging, treatment and management of patients. Prostate specific membrane antigen (PSMA), highly over-expressed on PCa cells, is an excellent target for selective imaging of PCa. In recent years, various scaffolds have been explored as potential carriers to target diagnostic and therapeutic agents to PSMA+ tumour cells. Numerous fluorescent or radioisotope probes linked via a peptide linker have been developed that selectively binds to PCa cells. However, there are very few reports that examine the effects of chemical modifications in the peptide linker of an imaging probe on its affinity to PSMA protein. This report systematically investigates the impact of hydrophobic aromatic moieties in the peptide linker on PSMA affinity and in vitro performance. For this, a series of fluorescent bioconjugates 12–17 with different aromatic spacers were designed, synthesized, and their interactions within the PSMA pocket were first analysed in silico. Cell uptake studies were then performed for 12–17 in PSMA+ cell lines and 3D tumour models in vitro. Binding affinity values of 12–17 were found to be in the range of 36 to 157.9 nM, and 12 with three aromatic groups in the spacer exhibit highest affinity (KD = 36 nM) compared to 17 which is devoid of aromatic groups. These studies suggest that aromatic groups in the spacer region can significantly affect deep tissue imaging of fluorescent bioconjugates. Bioconjugate 12 can be a promising diagnostic tool, and conjugation to near-infrared agents would further its applications in deep-tissue imaging and surgery. Communicated by Ramaswamy H. Sarma
Upgrading a paper machine dryer section
Creators: name: Merlo, W. Gilbert.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A Search for Stellar-Mass Black Holes via Astrometric Microlensing
Creators: name: Lu, J. R.
name: Sinukoff, E.
name: Ofek, E. O.
name: Udalski, A.
name: Kozlowski, S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: While dozens of stellar mass black holes have been discovered in binary systems, isolated black holes have eluded detection. Their presence can be inferred when they lens light from a background star. We attempt to detect the astrometric lensing signatures of three photometrically identified microlensing events, OGLE-2011-BLG-0022, OGLE-2011-BLG-0125, and OGLE-2012-BLG-0169 (OB110022, OB110125, and OB120169), located toward the Galactic Bulge. These events were selected because of their long durations, which statistically favors more massive lenses. Astrometric measurements were made over 1-2 years using laser-guided adaptive optics observations from the W. M. Keck Observatory. Lens model parameters were first constrained by the photometric light curves. The OB120169 light curve is well-fit by a single-lens model, while both OB110022 and OB110125 light curves favor binary-lens models. Using the photometric fits as prior information, no significant astrometric lensing signal was detected and all targets were consistent with linear motion. The significant lack of astrometric signal constrains the lens mass of OB110022 to 0.05-1.79 Msun in a 99.7% confidence interval, which disfavors a black hole lens. Fits to OB110125 yielded a reduced Einstein crossing time and insufficient observations during the peak, so no mass limits were obtained. Two degenerate solutions exist for OB120169, which have a lens mass between 0.2-38.8 Msun and 0.4-39.8 Msun for a 99.7% confidence interval. Follow-up observations of OB120169 will further constrain the lens mass. Based on our experience, we use simulations to design optimal astrometric observing strategies and show that, with more typical observing conditions, detection of black holes is feasible.
description: Accepted for publication in ApJ
Becoming somebody: Black womens escrevivncias and politics of resistance
Creators: name: Gomes Peixoto, Irimara
Publisher: name: Georgia State University
Year: 2023

description:
Assata Shakur and Marielle Franco were activists fighting for racial and gender equality in the United States and Brazil. This work aims to observe their life stories and legacies, analyzing the documentary Marielle: The Crime That Shook Brazil and Assata Shakurs memoir Assata: An Autobiography. This study will focus on the differences and similarities in their countries justice systems and how Franco and Shakur built strategies of resistance to navigate their homeland's necropolitics and also focus on the process of recognizing the self, using the concept of escrevivncias. Therefore, observing how their political views and positions directly cause their exile and death. Two methodologies, narrative analysis and analysis of the discourse will uncover the similarities between the discourses presented in the documentary and the autobiography. Pointing out how political consciousness is a significant factor in the life of Black women both in Brazil and the United States.
Universal transport dynamics in a quenched tunnel-coupled Luttinger liquid
Creators: name: Gambetta, F. M.
name: Cavaliere, F.
name: Citro, R.
name: Sassetti, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The transport dynamics of a quenched Luttinger liquid tunnel-coupled to a fermionic reservoir is investigated. In the transient dynamics, we show that for a sudden quench of the electron interaction universal power-law decay in time of the tunneling current occurs, ascribed to the presence of entangled compound excitations created by the quench. In sharp contrast to the usual non universal power-law behavior of a zero-temperature non-quenched Luttinger liquid, the steady state tunneling current is ohmic and can be explained in terms of an effective quench-activated heating of the system. Our study unveils an unconventional dynamics for a quenched Luttinger liquid that could be identified in quenched cold Fermi gases.
description: 9 pages, 4 figures
Ohh He Likes the Girls: A Genealogy of the Tranny Chaser
Creators: name: Hardy, Dennis
Publisher: name: Georgia State University
Year: 2023

description:
Research presented in this project examines how the social construction of sexuality affects cisgender (cis) men's attraction to transgender women. While mainstream discourse roots gender normative males' attraction to transgender women in heterosexuality, this project demonstrates how cis-trans pairings emerged from homosexuality in the twentieth century. This project traces the way sexologists' elaboration of the differences between sex, gender, and sexuality helped to distinguish transfeminine people from trans-attracted gender normative males using Foucauldian genealogy. Further, this project examines how researchers have adapted nineteenth-century frameworks of same-sex desires as sexual fetishes to construct gender-conforming healthy desires aimed at transsexual women by using the elaboration of these categories in the science of transsexualism. By doing so, this project illustrates how researchers deemphasized the body of trans people and elevated their gender to ensure a white middle-class cis-normative society.
Benchmarking of institutional Open Access policies and assessment of their readiness in adopting an Open Science Policy
Creators: name: Cheradi, Natalia
name: Țurcan, Nelly
name: Dobrea, Olesea
name: Lupu, Viorica
name: Silivestru, Diana
Publisher: name: Zenodo
Year: 2023
Subjects: Open Access, Open Science, institutional Open Access policies, Open Access mandates

description: The deliverable contains the result of the analysis and benchmarking regarding the institutional Open Access policies, and presents a support for the preparation of the implementation stage of the Open Science policies in the Republic of Moldova.
Short term prediction of extreme returns based on the recurrence interval analysis
Creators: name: Jiang, Zhi-Qiang
name: Wang, Gang-Jin
name: Canabarro, Askery
name: Podobnik, Boris
name: Xie, Chi
name: Stanley, H. Eugene
name: Zhou, Wei-Xing
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Finance (q-fin.ST)
subject: Risk Management (q-fin.RM)
subject: FOS: Economics and business

description: Being able to predict the occurrence of extreme returns is important in financial risk management. Using the distribution of recurrence intervals---the waiting time between consecutive extremes---we show that these extreme returns are predictable on the short term. Examining a range of different types of returns and thresholds we find that recurrence intervals follow a $q$-exponential distribution, which we then use to theoretically derive the hazard probability $W(Δt |t)$. Maximizing the usefulness of extreme forecasts to define an optimized hazard threshold, we indicates a financial extreme occurring within the next day when the hazard probability is greater than the optimized threshold. Both in-sample tests and out-of-sample predictions indicate that these forecasts are more accurate than a benchmark that ignores the predictive signals. This recurrence interval finding deepens our understanding of reoccurring extreme returns and can be applied to forecast extremes in risk management.
description: 18 pages, 5 figues, 3 tables
Study of potentiality of dexamethasone and its derivatives against Covid-19
Creators: name: Mitra, Debanjan
name: Paul, Manish
name: Thatoi, Hrudayanath
name: Mohapatra, Pradeep K. Das
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: In December 2019, COVID-19 epidemic was reported in Wuhan, China, and subsequently the infection has spread all over the world and became pandemic. The death toll associated with the pandemic is increasing day by day in a high rate. Herein, an effort has been made to identify the potentiality of commercially available drugs and also their probable derivatives for creation of better opportunity to make more powerful drugs against coronavirus. This study involves the in-silico interactions of dexamethasone and its derivatives against the multiple proteins of SARS-CoV-2 with the help of various computational methods. Descriptor parameters revealed their non-toxic effect in the human body. Ultimately docking studies and molecular dynamic simulation on those target protein by dexamethasone and its derivatives showed a high binding energy. Dexamethasone showed −9.8 kcal/mol and its derivative D5 showed −12.1 kcal/mol binding energy. Those scores indicate that dexamethasone has more therapeutic effect on SARS CoV-2 than other currently used drugs. Derivatives give the clue for the synthesis of a novel drug to remove SARS CoV-2. Until then, dexamethasone will be used as a potential inhibitor of SARS CoV-2. Communicated by Ramaswamy H. Sarma
Composite Functional Metasurfaces for Multispectral Achromatic Optics
Creators: name: Avayu, Ori
name: Almeida, Euclides
name: Prior, Yehiam
name: Ellenbogen, Tal
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Nanostructured metasurfaces offer unique capabilities for local control of the phase and amplitude of transmitted and reflected optical waves. Based on this potential, a large number of metasurfaces have been proposed in recent years as alternatives to standard optical elements. In most cases, however, these elements suffer from large chromatic aberrations, thus limiting their usefulness for multi-wavelength or broadband applications. Here, in order to alleviate and correct the chromatic aberrations of individual diffractive elements, we introduce dense vertical stacking of independent metasurfaces, where each layer comprises a different material, and is optimally designed for a different band within the visible spectrum. Using this approach, we demonstrate the first triply RGB achromatic metalens in the visible range and perform color imaging with this lens. We further demonstrate functional beam shaping by constructing a self-aligned integrated element for Stimulated Emission Depletion (STED) microscopy and a lens that provides anomalous dispersive focusing. These demonstrations lead the way to the realization of superachromatic ultrathin optical elements and multiple functional operations, all in in a single nanostructured ultrathin element.
Additional file 1 of Routine developmental screening in Australian general practice: a pilot study
Creators: name: Alexander, Karyn
name: Mazza, Danielle
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 1.
Low-pressure phase diagram of crystalline benzene from quantum Monte Carlo
Creators: name: Azadi, Sam
name: Cohen, R. E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We study the low-pressure (0 to 10 GPa) phase diagram of crystalline benzene using quantum Monte Carlo (QMC) and density functional theory (DFT) methods. We consider the $Pbca$, $P4_32_12$, and $P2_1/c$ structures as the best candidates for phase I and phase II. We perform diffusion quantum Monte Carlo (DMC) calculations to obtain accurate static phase diagrams as benchmarks for modern van der Waals density functionals. We use density functional perturbation theory to compute phonon contribution in the free-energy calculations. Our DFT enthalpy-pressure phase diagram indicates that the $Pbca$ and $P2_1/c$ structures are the most stable phases within the studied pressure range. The DMC Gibbs free-energy calculations predict that the room temperature $Pbca$ to $P2_1/c$ phase transition occurs at 2.1(1) GPa. This prediction is consistent with available experimental results at room temperature. Our DMC calculations show an estimate of 50.6$\pm$0.5 kJ/mol for crystalline benzene lattice energy.
Design of a secondary fibre treatment system
Creators: name: Wightwick, Scott M.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Elaborarea și implementarea politicilor instituționale privind managementul datelor de cercetare: Ghid pentru instituțiile de cercetare = Developing and Implementing Institutional Research Data Management Policies: Guidelines for Research Institutions
Creators: name: Mihai, Grecu
name: Viorica, Lupu
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Research Data Management
Institutional Policy
Research Institutions

description: Modern research is based on extensive scientific dialogue advances made advances building upon improving previously conducted research. Wider access to publications and scientific data helps to: - Improving the quality of results based on previous research data. - Increasing research efficiency by encouraging collaboration and avoiding duplication in research activities. Developing and Implementing Institutional Research Data Management Policies: Guidelines for Research Institutions. Modern research is based on extensive scientific dialogue advances made advances building upon improving previously conducted research. Wider access to publications and scientific data helps to:
 - improving the quality of results based on previous research data;
 - increasing research efficiency by encouraging collaboration and avoiding duplication in research activities;
 - acceleration of innovation and technological transfer;
 - the wider involvement of citizens and society by improving the transparency of the scientific research process.
 In this context, it is necessary to improve access to scientific information, thus stimulating the benefits of public investment in research. Research activities in today's conditions require improved infrastructures to address a significant challenge related to the optimal utilization of data and research methods. The challenge refers to the proper management of data from scientific research, which ensures the integration and reuse of data and knowledge as a priority condition for capitalizing on research results. It also aims to facilitate new discoveries and innovations. Emphasis is placed on the availability of research data in digital form.
 This guide provides suggestions on how to implement the principles outlined in the Institutional Research Data Management Policies in practice. The guide is intended for research organizations.
Combined molecular docking and dynamics simulations studies of natural compounds as potent inhibitors against SARS-CoV-2 main protease
Creators: name: Ouassaf, Mebarka
name: Belaidi, Salah
name: Chtita, Samir
name: Lanez, Touhami
name: Qais, Faizan Abul
name: Amiruddin, Hashmi Md
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Main protease (Mpro) of SARS-CoV-2 is a key CoV enzyme that plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for SARS-CoV-2 the new strain of coronavirus. In this study, we evaluated biologically active compounds present in medicinal plants as potential SARS-CoV-2 Mpro inhibitors, using a molecular docking study with Autodock Vina software. Top seven compounds Afzelin, Phloroglucinol, Myricetin-3-O- rutinosid Tricin 7-neohesperidoside, Silybin, Kaempferol and Silychristin among 50 molecules of natural Origin (Algerian Medicinal plants) were selected which had better and significantly low binding energy as compared to the reference molecule with binding affinities of −9.3, −9.3, −9, −8.9, −8.5, 8.3 and −8.3 kcal mol−1 respectively. Then, we analyzed the ADME properties of the best 7 ligands using the Web server SwissADME. Two of small molecules have been shown to be the ideal candidates for further drug development. Finally, the stability of the both compounds complexed with Mpro was validated through molecular dynamics (MD) simulation, they displayed stable trajectory (RMSD, RMSF) and molecular properties with consistent interaction profile in molecular dynamics simulations, moreover, Silybin could form more stable complex with Mpro than Silychristin. Communicated by Ramaswamy H. Sarma
X-ray Pulsars
Creators: name: Walter, Roland
name: Ferrigno, Carlo
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: X-ray pulsars shine thanks to the conversion of the gravitational energy of accreted material to X-ray radiation. The accretion rate is modulated by geometrical and hydrodynamical effects in the stellar wind of the pulsar companions and/or by instabilities in accretion discs. Wind driven flows are highly unstable close to neutron stars and responsible for X-ray variability by factors $10^3$ on time scale of hours. Disk driven flows feature slower state transitions and quasi periodic oscillations related to orbital motion and precession or resonance. On shorter time scales, and closer to the surface of the neutron star, X-ray variability is dominated by the interactions of the accreting flow with the spinning magnetosphere. When the pulsar magnetic field is large, the flow is confined in a relatively narrow accretion column, whose geometrical properties drive the observed X-ray emission. In low magnetized systems, an increasing accretion rate allows the ignition of powerful explosive thermonuclear burning at the neutron star surface. Transitions from rotation- to accretion-powered activity has been observed in rare cases and proved the link between these classes of pulsars.
description: Chapter of the forthcoming Handbook of Supernovae, edited by Athem W. Alsabti and Paul Murdin, Springer Verlag
Integração de repositórios de dados abertos para certificação de produção científica
Creators: name: Segundo, Washington
name: Dias, Thiago Magela Rodrigues
name: Moreira, Tales Henrique José
name: Silva, Vivian dos Santos
name: Chalco, Jesús Pascual Mena
Publisher: name: Zenodo
Year: 2023

description: Apresentação realizada na sessão "Pecha Kucha I" da 14ª Conferência Lusófona de Ciência Aberta, Natal Brasil, de 18 a 21 de setembro de 2023.
The mechanical properties of SiC/Aluminium metal matrix composites
Creators: name: Sharp, P. Khan
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Photocentric orbits from a direct combination of ground-based astrometry with Hipparcos II. Preliminary orbits for six astrometric binaries
Creators: name: Gontcharov, G. A.
name: Kiyaeva, O. V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Based on a direct combination of the Hipparcos data with astrometric ground-based observational catalogues having epochs between 1938 and 1999 the preliminary orbits and component masses are calculated for 6 binaries with no previous orbit calculation: $ι$~Vir (HIP~69701) with period of 55 years, photocentric semi-major axis of 200 mas, relative semi-major axis of 830 mas and a dwarf secondary of 0.6 solar masses; $γ$~UMa (HIP~58001) -- 20.5 years, 90 mas, 460 mas and a dwarf secondary of 0.8 solar masses; $κ$~Del (HIP~101916) -- 45 years, 100 mas, 520 mas and a dwarf secondary of 0.4 solar masses; 20~Oph (HIP~82369) -- 35.5 years, 140 mas, 460 mas and a dwarf secondary of 0.8 solar masses; $μ$~Ser (HIP~77516) -- 36 years, 110 mas, 350 mas and a secondary of 2.3 solar masses; as well as a possible new component of Mizar~A ($ζ$~UMa, HIP~65378) -- 36.5 years, 180 mas, 780 mas, 1.5 solar masses. The latter may be a pair of dwarfs.
description: 6 figures, 5 tables
Additional file 1 of Randomized double-blind personalized N-of-1 clinical trial to test the safety and potential efficacy of TJ-68 for treating muscle cramps in amyotrophic lateral sclerosis (ALS): study protocol for a TJ-68 trial
Creators: name: Mitsumoto, Hiroshi
name: Cheung, Ken
name: Oskarsson, Björn
name: Andrews, Howard F.
name: Jang, Grace E.
name: Andrews, Jinsy A.
name: Shah, Jaimin S.
name: Fernandes, Joseph Americo
name: McElhiney, Martin
name: Santella, Regina M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Science Policy

description: Additional file 1: Supplement Table 1. Serious Adverse Events (SAEs). Supplement Table 2. Consideration of Causality of Adverse Events and Expectedness in the Couse of ALS. Supplement Table 3. Dealing with Unanticipated Problems (UPs). Supplement Table 4. Removal of Patients from Study Participation. Supplement Table 5. Participant’s Withdrawal.
Xenia fusca , Schenk 1896
Creators: name: Halász, Anna
name: Mcfadden, Catherine S.
name: Toonen, Robert
name: Benayahu, Yehuda
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Xeniidae
Xenia
Xenia fusca

description: Xenia fusca Schenk, 1896
Fig. 6
Xenia fusca Schenk, 1896: 59
Material. Syntype: SMF 40, Indonesia, Ternate Island, 1894, coll. W. Kükenthal.
Description. The syntype is 38 mm high; its stalk is 32 mm long and 18 mm wide at its base, 25 mm wide at its uppermost part. The polyp body is up to 3 mm long, and the tentacles are up to 2.5–3 mm long, featuring mostly four rows of pinnules along each of the tentacle margins. Occasionally 3 and even 5 rows are present. The pinnules are relatively short and stout, up to 0.25 mm long and 0.10 mm wide, 14–22 in the outermost row, spacing ranging from no gap to up to a half pinnule-wide space between adjacent pinnules.
Sclerites are abundant in all parts of the colony; they are ellipsoid platelets, 0.006 –0.014 X 0.013 –0.019 mm in diameter (Fig. 6a, n =20). The sclerites are composed of dendritic rods assembled within the sclerite interior (Fig. 6b), providing a granular appearance to the sclerite surface. Few fractured sclerites were observed, and they remained intact after preparation (Fig. 6c). The ethanol-preserved holotype is dark gray in color.
Remarks. In the original description of X. fusca, Schenk (1896) indicated that the species has 6–7 irregular rows of pinnules and 13–14 pinnules in each row, as opposed to the current findings that revealed mostly four rows and 14–22 pinnules in the outermost row. The dimensions of the sclerites obtained in the current study correspond to the original description. The sclerites of the type of Xenia fusca differ from those commonly occurring among other Xenia species (e.g., X. bauiana: Fig. 2, X. blumi: Fig. 3, X. garciae Bourne, 1894: Fig.7), feature a densely packed granular surface, and do not exhibit the typical radial cracks under SEM (e.g. X. blumi: Fig. 3, X. plicata: Fig. 4).
Similar species and conclusion. X. fusca and Xenia rubens Schenk, 1896 feature mostly four rows of pinnules and a similar number of pinnules in the outermost row. They also share the same type of sclerite surface but the internal structure of their sclerites differs: the latter with wide rods and a void in the interior and the former with randomly arranged calcite rods (Figs. 13 and 6, respectively). Therefore, it is concluded that the two species should be considered as separate until further data on freshly collected colonies and their sclerite microstructure become available.
Distribution. Indonesia: Ternate Island.
description: Published as part of Halász, Anna, Mcfadden, Catherine S., Toonen, Robert & Benayahu, Yehuda, 2019, Re-description of type material of Xenia Lamarck, 1816 (Octocorallia: Xeniidae), pp. 201-239 in Zootaxa 4652 (2) on pages 211-212, DOI: 10.11646/zootaxa.4652.2.1, http://zenodo.org/record/3363653
Bottle microresonator broadband and low repetition rate frequency comb generator
Creators: name: Dvoyrin, V.
name: Sumetsky, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We propose a new type of broadband and low repetition rate frequency comb generator which has the shape of an elongated and nanoscale-shallow optical bottle microresonator created at the surface of an optical fiber. The free spectral range (FSR) of the broadband azimuthal eigenfrequency series of this resonator is the exact multiple of the FSR of the dense and narrowband axial series. The effective radius variation of the microresonator is close to a parabola with a nanoscale height which is greater or equal to lambda/2pi*n0 (here lambda is the characteristic radiation wavelength and n0 is the refractive index of the microresonator material). Overall, the microresonator possesses a broadband, small FSR, and accurately equidistant spectrum convenient for the generation of a broadband and low repetition rate optical frequency comb. It is shown that this comb can be generated by pumping with a cw laser, which radiation frequency matches a single axial eigenfrequency of the microresonator, or, alternatively, by pumping with a mode-locked laser, which generates a narrowband low repetition rate comb matching a series of equidistant axial eigenfrequencies situated between adjacent azimuthal eigenfrequencies.
description: 4 pages
Materials to improve professional language skills for teachers in the new country: scenario ‘reorientation of a student’
Creators: name: D’Herdt, Katrijn
name: Oruc Erturk, Nesrin
name: Holz, Oliver
name: Hachmeister, Silke
name: Hopton, Cherry
name: Petursdottir, Gudrun
Publisher: name: Univ. Bielefeld, Fakultät für Erziehungswissenschaft
Year: 2023
Subjects: subject: 370

description: The scenarios in this chapter will help international teachers to focus on both active and passive language skills, namely: speaking/writing and reading/listening by giving them possible scenarios which international teachers may come across in their daily teaching environments. All the documents consist of concrete materials. None of the materials provided include an evaluation or assessment, as the focus is on practicing. Furthermore, it is possible to work with the materials both face-to-face and in online situations. The first part of the scenarios was developed by the IQ Netzwerk from Germany and afterwards summarized and translated. In addition, three new scenarios have been developed within the ITTS project: ‘solving a conflict’, ‘reorientation of a student’, ‘preparing your future’. The scenario on ‘reorientation of a student’ can be found below.
Synthesis, antioxidant, in silico and computational investigation of 2,5-dihydroxyacetophenone derived chloro-substituted hydroxychalcones, hydroxyflavanones and hydroxyflavindogenides
Creators: name: Siddiqa, Aysha
name: Tajammal, Affifa
name: Irfan, Ahmad
name: Munawar, Munawar Ali
name: Azam, Muhammad
name: Basra, Muhammad Asim Raza
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: An imbalance between reactive oxygen species (ROS) and their elimination by antioxidants damages the cell and infect whole organism. The biological defence system against oxidative stress injury is Kelch-like ECH associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elements (ARE) pathways. Antioxidants activate the Nrf2-ARE-Keap1 pathway and suppress the oxidative stress. Flavonoids are well known medicinal compounds inheriting antioxidant efficacy and wide spectrum of pharmacological activities. The study is aimed to synthesise, characterize and evaluate pharmacological activities of synthesized chloro-derivatives of flavonoids. Chloro-derivatives of flavonoids were synthesized and characterized by IR, 1H NMR and 13C NMR. Antioxidant potential of each synthesized compound was evaluated and then subjected to molecular docking with Keap1 (PDB ID: 2FLU) for the activation of Nrf2 and computational studies were performed by using DFT approach. Among the synthesized compounds compound 1a exhibited lower IC50 value. While docking and computational studies infer that compound 3c is a good Nrf2 activator and radical scavenger with highest docking score and lower energy gaps and IP values compared to references. Hence, it might be considered for further molecular studies for the treatment of inflammatory diseases through Nrf2-ARE-Keap1 pathway. Communicated by Ramaswamy H. Sarma. HighlightsChloro-substituted hydroxychalcones, hydroxyflavanones and hydroxyflavindogenides were synthesized.Antioxidant potential was accessed, compound 1a exhibited good antioxidant potential.In silico study was performed with Keap1, compound 3c have shown highest docking score with Keap1.DFT approach was used to explore the structure activity relationship. Chloro-substituted hydroxychalcones, hydroxyflavanones and hydroxyflavindogenides were synthesized. Antioxidant potential was accessed, compound 1a exhibited good antioxidant potential. In silico study was performed with Keap1, compound 3c have shown highest docking score with Keap1. DFT approach was used to explore the structure activity relationship.
Computer Folding of RNA Tetraloops: Identification of Key Force Field Deficiencies
Creators: name: Kührová, Petra
name: Best, Robert B.
name: Bottaro, Sandro
name: Bussi, Giovanni
name: Šponer, Jiří
name: Otyepka, Michal
name: Banáš, Pavel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Biomolecules (q-bio.BM)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The computer-aided folding of biomolecules, particularly RNAs, is one of the most difficult challenges in computational structural biology. RNA tetraloops are fundamental RNA motifs playing key roles in RNA folding and RNA-RNA and RNA-protein interactions. Although state-of-the-art Molecular Dynamics (MD) force fields correctly describe the native state of these tetraloops as a stable free-energy basin on the microsecond time scale, enhanced sampling techniques reveal that the native state is not the global free energy minimum, suggesting yet unidentified significant imbalances in the force fields. Here, we tested our ability to fold the RNA tetraloops in various force fields and simulation settings. We employed three different enhanced sampling techniques, namely, temperature replica exchange MD (T-REMD), replica exchange with solute tempering (REST2), and well-tempered metadynamics (WT-MetaD). We aimed to separate problems caused by limited sampling from those due to force-field inaccuracies. We found that none of the contemporary force fields is able to correctly describe folding of the 5'-GAGA-3' tetraloop over a range of simulation conditions. We thus aimed to identify which terms of the force field are responsible for this poor description of TL folding. We showed that at least two different imbalances contribute to this behavior, namely, overstabilization of base-phosphate and/or sugar-phosphate interactions and underestimated stability of the hydrogen bonding interaction in base pairing. The first artifact stabilizes the unfolded ensemble, while the second one destabilizes the folded state. The former problem might be partially alleviated by reparametrization of the van der Waals parameters of the phosphate oxygens suggested by Case et al., while in order to overcome the latter effect we suggest local potentials to better capture hydrogen bonding interactions.
description: Reprinted with permission from J. Chem. Theory Comput. 2016, 12 (9), pp 4534-4548. Copyright 2016 American Chemical Society
Additional file 1 of 17q25.3 copy number changes: association with neurodevelopmental disorders and cardiac malformation
Creators: name: Sahajpal, Nikhil Shri
name: Jeffrey, David H. F.
name: DuPont, Barbara R.
name: Hilton, Benjamin
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Physical measurements and percentiles for 15 cases harboring CNVs in the 17q25.3 region.
Finite element analysis of ZVC/500 machine center
Creators: name: Bastekeli, Nuri.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Reimagining Gender and Sex: The Construction and Consumption of the Omegaverse
Creators: name: Ming, Yan
Publisher: name: University of Chicago
Year: 2022
Subjects: subject: Gender
subject: Sex
subject: Omegaverse

description: What is the relationship between gender and sex? What does a male body mean in the gender system? This thesis examines the popularity of the Omegaverse, an alternative gender system, and tries to explain why the Omegaverse has become a popular sub-genre in BL(Boy Love) stories, which involves the idealized romantic relationships between two cis male characters. The Omegaverse has provided an alternative universe in which biological sex markers, male and female genitals, are no longer the determining factor for sex. In other words, female and male identities no longer determine individuals’ social status yet popular stories involving the Omegaverse often incorporate two male characters. This thesis adopts content analysis on four of the most popular works on the Omegaverse and conversations happening on social media platforms surrounding the concept of the Omegaverse as well as interviews with the readers of these works. Through investigating the role male bodies play in the Omegaverse fictions, this thesis argues that male bodies serve as a symbol for success even when they are not functioning as a biological determining marker.
Additional file 2 of 17q25.3 copy number changes: association with neurodevelopmental disorders and cardiac malformation
Creators: name: Sahajpal, Nikhil Shri
name: Jeffrey, David H. F.
name: DuPont, Barbara R.
name: Hilton, Benjamin
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Available phenotypes of family members for all 15 cases harboring CNVs in the 17q25.3 region.
A comparative study of different docking methodologies to assess the protein–ligand interaction for the E. coli MurB enzyme
Creators: name: Nirwan, Sonam
name: Chahal, Varun
name: Kakkar, Rita
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: We have investigated the active site of E. coli MurB using the Quantum Mechanics/Molecular Mechanics (QM/MM) methodology. The docking of three novel series of 4-thiazolidinone derivatives has been performed using two methods: rigid docking and flexible docking (Induced Fit Docking: IFD). The results have been compared to understand the conformational aspects of the enzyme. The docking results from rigid docking show that the ligands with highly negative ΔGbind have poor docking scores. In addition, the value of the regression coefficient (R) obtained on correlating the ΔGbind and the experimental pMIC values is insignificant. On keeping the protein flexible, there is a remarkable improvement in both the docking score and ΔGbind, along with a good value of R (0.64). Two important residues, Tyr254 and Try190 are found to be highly displaced during the flexible docking and hence their role in effective ligand binding has been confirmed. Thus, comparing the two methodologies, IFD has emerged as the more appropriate one for studying the E. coli MurB enzyme. To further substantiate the findings, MD studies over a time period of 20 ns have been performed on the IFD-LIII j and Rigid/XP-LIII j complexes and the results shows the former complex to be more stable, with lower average RMSD and higher average ΔGbind. Communicated by Ramaswamy H. Sarma
Materials to improve professional language skills for teachers in the new country: scenario ‘solving a classroom conflict’
Creators: name: D’Herdt, Katrijn
name: Oruc Erturk, Nesrin
name: Holz, Oliver
name: Hachmeister, Silke
name: Hopton, Cherry
name: Petursdottir, Gudrun
Publisher: name: Univ. Bielefeld, Fakultät für Erziehungswissenschaft
Year: 2023
Subjects: subject: 370

description: The scenarios in this chapter will help international teachers to focus on both active and passive language skills, namely: speaking/writing and reading/listening by giving them possible scenarios which international teachers may come across in their daily teaching environments. All the documents consist of concrete materials. None of the materials provided include an evaluation or assessment, as the focus is on practicing. Furthermore, it is possible to work with the materials both face-to-face and in online situations. The first part of the scenarios was developed by the IQ Netzwerk from Germany and afterwards summarized and translated. In addition, three new scenarios have been developed within the ITTS project: ‘solving a classroom conflict’, ‘reorientation of a student’, ‘preparing your future as a teacher’. The scenario on ‘solving a classroom conflict’ can be found below.
Trigonometric collocation methods based on Lagrange basis polynomials for multi-frequency oscillatory second-order differential equations
Creators: name: Wang, Bin
name: Wu, Xinyuan
name: Meng, Fanwei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In the present work, a kind of trigonometric collocation methods based on Lagrange basis polynomials is developed for effectively solving multi-frequency oscillatory second-order differential equations $q^{\prime\prime}(t)+Mq(t)=f\big(q(t)\big)$. The properties of the obtained methods are investigated. It is shown that the convergent condition of these methods is independent of $\norm{M}$, which is very crucial for solving oscillatory systems. A fourth-order scheme of the methods is presented. Numerical experiments are implemented to show the remarkable efficiency of the methods proposed in this paper.
Laser-Induced Electron Diffraction: Inversion of Photoelectron Spectra for Molecular Orbital Imaging
Creators: name: Puthumpally-Joseph, R.
name: Viau-Trudel, J.
name: Peters, M.
name: Nguyen-Dang, T. T.
name: Atabek, O.
name: Charron, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we discuss the possibility of imaging molecular orbitals from photoelectron spectra obtained via Laser Induced Electron Diffraction (LIED) in linear molecules. This is an extension of our work published recently in Physical Review A \textbf{94}, 023421 (2016) to the case of the HOMO-1 orbital of the carbon dioxide molecule. We show that such an imaging technique has the potential to image molecular orbitals at different internuclear distances in a sub-femtosecond time scale and with a resolution of a fraction of an Angström.