Additional file 1 of Race and ethnicity in the COVID-19 Critical Care Consortium: demographics, treatments, and outcomes, an international observational registry study
Creators: name: Griffee, Matthew J.
name: Thomson, David A.
name: Fanning, Jonathon
name: Rosenberger, Dorothea
name: Barnett, Adrian
name: White, Nicole M.
name: Suen, Jacky
name: Fraser, John F.
name: Li Bassi, Gianluigi
name: Cho, Sung-Min
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1: Supplementary Figure 1. Diagram of time-to-event models: Model 1 is for the competing risks of discharge (discharged alive) and death. Model 2 is for competing risks of discharged alive, death, and mechanical ventilation. Supplementary Figure 2. 2A: Distribution of ethnicities in the US cohort, using US Census categories. 2B: Distribution of ethnicities in the Australian cohort, using the original case report form categories. 2C: Distribution of ethnicities in the South African cohort, using South African government categories. Percentages are given in each category and patient counts are along the X-axis. Supplementary Figure 3. Comorbidities, US Cohort. Supplementary Figure 4. Apache II scores by ethnicity, US Cohort. The box extends from the first to the third quartile. The line in the box is the median score. The upper and lower whiskers extend from the box to the largest and smallest scores, no further than 1.5 inter-quartile ranges from the box. Scores beyond the end of the whiskers are outlying points and are plotted individually. Supplementary Figure 5A. Cumulative probability of mortality and discharged alive, US cohort. For the designated ethnicity, the red curve represents the cumulative probability of death, the blue curve the cumulative probability of discharged alive, with days along the x-axis. Supplementary Figure 5B. Cumulative probability of mortality and discharged alive, Australian cohort. For the designated ethnicity, the red curve represents the cumulative probability of death, the blue curve the cumulative probability of discharged alive, with days along the x-axis. Supplementary Figure 5C. Cumulative probability of mortality and discharged alive, South African cohort. For the designated ethnicity, the red curve represents the cumulative probability of death, the blue curve the cumulative probability of discharged alive, with days along the x-axis. Supplementary Figure 6A. Hazard of death (left panel) and discharged alive (right panel) by ethnicity, US cohort, after adjustment by age and site. The blue dot is the hazard ratio for death (left panel) and discharged alive (right panel) and the blue whiskers are the 95% credible intervals. Supplementary Figure 6B. Hazard of death (left panel) and discharged alive (right panel) by ethnicity, US cohort, after adjustment only for age. The blue dot is the hazard ratio for death (left panel) and discharged alive (right panel) and the blue whiskers are the 95% credible intervals. Supplementary Figure 6C. Hazard of death (left panel) and discharged alive (right panel) by ethnicity, US cohort, after adjustment only for site. The blue dot is the hazard ratio for death (left panel) and discharged alive (right panel) and the blue whiskers are the 95% credible intervals. Supplementary Figure 7. Sensitivity analysis, allowing effect of ethnicity to vary by site using a site-specific effect for ethnicity in a random effects model. The hazard ratio for death for each site, compared to the average across all sites, is the central dot, with sites arranged vertically. The whiskers are 95% credible intervals. Sites with statistically significant increased or decreased hazard ratios for death, compared to the overall average for all sites (for the specified ethnicity), are in orange. Supplementary Figure 8. Comorbidities by ethnicity, Australian cohort. Designations are the same format as for Supplementary figure 2. Supplementary Figure 9. Sequential Organ Failure Assessment Score by Ethnicity, Australian Cohort: The box extends from the first to the third quartile. The line in the box is the median score. The upper and lower whiskers extend from the box to the largest and smallest scores, no further than 1.5 inter-quartile ranges from the box. Scores beyond the end of the whiskers are outlying points and are plotted individually. Supplementary Figure 10A. Hazard of discharged alive by ethnicity for each site, Australian cohort. Dots are hazard ratios and whiskers are 95% credible intervals. Sites are arranged vertically. Orange dots designate sites with hazard of discharged alive with statistically significant increased or decreased hazards of discharge, compared to the overall average across all sites for the specified ethnicity. Supplementary Figure 10B. Hazard of death by ethnicity for each site, Australian cohort. Dots are hazard ratios and whiskers are 95% credible intervals. Sites are arranged vertically. Orange dots designate sites with hazards with statistically significant increased or decreased hazards of death, compared to the overall average across all sites, for the specified ethnicity. Supplementary Figure 11. Sequential Organ Failure Assessment score by ethnicity, South African cohort. The box extends from the first to the third quartile. The line in the box is the median score. The upper and lower whiskers extend from the box to the largest and smallest scores, no further than 1.5 inter-quartile ranges from the box. Scores beyond the end of the whiskers are outlying points and are plotted individually. Supplementary Figure 12. A-C Cumulative probability of mechanical ventilation, US cohort (12A), Australian cohort (12B), South African cohort (12C). Y-axis- probability of mechanical ventilation, X-axis, days from first symptom. Supplementary Figure 13. The number of patients enrolled in COVID Critical (y-axis) based on date of admission (x-axis) for the U.S., South Africa, and Australia. Supplementary Figure 14A. Logistic regression for likelihood of missing APACHE II score by ethnicity. The reference group is the “Unanswered” ethnicity response category. Results below the reference line (less than an odds ratio of 1) are less likely to be missing; results above the reference line (odds ratio greater than 1) are more likely to be missing. Supplementary Figure 14B. Proportion of case reports missing APACHE II by Site, US Cohort. The site number is along the X-axis. The black dot indicates the proportion of cases from the site missing APACHE II scores.