cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dybdeanalyse af trafikulykker med ældre bilister
Creators: name: Kjær, Marlene Rishøj
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Befolkningssammensætningen er under forandring, da vi får flere ældre og færre unge. Samtidigt kører flere og flere ældre bil og har planer om at blive ved at gøre det. Det vil komme til at ændre ulykkesbilledet. Ældre bilister er generelt rigtigt gode til at undlade højrisikoadfærd – eksempelvis høj fart og kørsel med sprit eller narkotika i blodet. Forhold der i dag udgør et stort problem for trafiksikkerheden. Alene på grund af den demografiske forandring kan vi således forvente en positiv udvikling. Men ældre bilister har også trafiksikkerhedsmæssige udfordringer. De er eksempelvis forholdsvis ofte involveret i vigepligtsulykker, og trafikulykker, hvor de mister bevidstheden. En ny temarapport fra HVU sætter fokus på ulykker med ældre bilister, og rapporten kommer med forklaringer på, hvorfor ulykkerne sker, og hvordan disse ulykker kunne være undgået. Den stadigt voksende gruppe af ældre har også betydning for trafikkens sammensætning, afvikling og ulykkesbillede. HVU har dybdeanalyseret 32 alvorlige ulykker med ældre bilister, og analysen viste at ulykkerne kan grupperes i tre forskellige ulykkestyper. • Ulykker, hvor den ældre fører ikke kunne undvige en modpart på kollisionskurs. Disse ulykker var ofte mødeulykker, men derudover havde de ingen fællestræk. • Ulykker med en ældre fører, som mistede bevidstheden. Ulykker af denne type dækker over forskellige årsager til bevidsthedstabet såsom; træthed, blackouts og forvirring • Ulykker, hvor den ældre fører havde vigepligten. Ulykkerne skete i vejkryds og viste et samspil mellem menneskelige fejl både den ældre bilist og modparten samt et udfordrende vejdesign.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Études de polyélectrolytes en solution libre par dynamique moléculaire
Creators: name: Bertrand, Martin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biophysics, General.

description: In the last few years, a new physics field is gaining much attention: biophysics. Physicists are especially well prepared to study and model some of the most complicated biological mechanisms. For example, many studies are now focused on better understanding the behavior of polymers such as DNA, RNA, and proteins to help develop techniques to manipulate and analyze these molecules. This thesis contains two such studies that were conducted using molecular dynamics simulations. The first concentrates on tethered polyelectrolytes under electrophoresis in free-solution. It presents results that, for the first time, directly confirm the equivalence principle as established by Didier Long, Jean-Louis Viovy, and Armand Ajdari. The second centers on confined polyelectrolytes under electrophoresis in free-solution where the radial confinement force is mechanical of origin and transverse to the net motion of the molecules. It redefines "free-draining", a most fundamental property of polyelectrolytes in free-solution, and points towards a new method for separating charged chains by size. One will also find, at the beginning of the thesis, two entire chapters dedicated to first, put the two studies in the proper context, and second, allow a better comprehension of the theory of polyelectrolytes in free-solution undergoing electrophoresis.
The effect of adhesive bondline thickness on joint strength
Creators: name: Gupta, Varun
Publisher: name: Washington State University
Year: 2014
Subjects: Adhesive joints
Figure--joints--bonded--thickness--adhesives--failure--bondline

description: Bondline thickness is an important factor considered when designing a bond joint. This project considered a ductile adhesive and a brittle adhesive to compare their effect on joint strength. Aluminum and composite adherends were used to bond using these two adhesives. The performance of an adhesive depends on the properties of the adhesive, the adherends being bonded, surface preparation on the adherends, the bondline thickness and the uniformity of the load. Optimal thickness of both the adhesives was determined by varying the bondline thickness. The ductile adhesive was found to be more sensitive to bondline variation than the brittle adhesive. The failure mode was cohesive for bondline thickness in the range of 0.002 - 0.012 inch and the failure mode transitioned from cohesive to adhesive over thickness 0.025 inch. The joint profile was tailored to determine the effect of varying bondline thickness along the gage section on the joint strength. Two profiles, concave and convex, were considered to study the behavior of adhesives. A third tapered profile was designed to study the manufacturing defects like misalignment which occurs during layup of the adhesive. The difference in the strength of concave and convex profile was observed to follow an opposite trend for the ductile and brittle adhesive. The ductile adhesive was more sensitive to tailored joints and stronger in the concave geometry; and the brittle adhesive was stronger in convex geometry. The failure mode for the tailored geometries was found to be a mix of cohesive and adhesive failure. The degree of cohesive failure was more in the convex profile for the ductile adhesive and in the tapered profile for the brittle adhesive.
Wet Sites Connections: Linking Indigenous Histories, Archaeology and the Public: Program and Abstracts
Creators: name: Croes, Dale R.
Publisher: name: Washington State University
Year: 2003
Subjects: Archaeology

description: As the Conference Coordinator for the 10th international Wetland Archaeology Research Project (WARP) Meeting, April 1-6, 2003, Olympia, Washington, i wanted to present the program events, field trips, banquet speakers (Bryony and John Coles), and Abstracts. The international WARP conference was held on the South Puget Sound Community College campus in conjunction with their 40th Anniversary. Sixty nine Wetland scholars from throughout the world presented their latest finds. Also we pondered the future in two panels. The presenters represented 9 countries. (UK: 15 (the country of origins of WARP), Canada: 13 (with a new 9,450 year old wet site on Queen Charlotte Islands), Japan: 10 (with amazing work throughout the country), and US: 20 (much on our local wet site of Qwu?gwes, as well as Florida), and exciting works in The Netherlands: 3, Denmark: 3, Ireland: 2, Sweden: 1, New Zealand: 2, Ukraine: 1--a truly international exchange on wet site efforts. The two panels will be of interest: When Will Wet Sites become Mainstream? (George F. MacDonald, coordinating) and a very good question in US, where you might expect more participation in this conference!) and Comprehensive Cultural Resource Management in Native American Country-Adding the Cultural Component to Scientific Research (Rhonda Foster, Squaxin Island Tribe, coordinating) with a broader discussion including the need for more wet site investigations. The Wet/Wetland/Waterlogged Archaeological Sites Preliminary Themes and Paper titles/authors/affiliations are provided in the Program and Abstract publication here.
Origin of coda waves : earthquake source resonance
Creators: name: Liu, Yinbin
Publisher: name: The University of British Columbia
Year: 2018

description: Coda in local earthquake exhibits resonance-like wave behaviour where the coda emerges as long-duration small-amplitude vibration with selective frequency, slow temporal decay, and uniform spatial energy distribution around the earthquake source. Coda is thought to be the incoherent waves scattered from random small-scale heterogeneity in the earth's lithosphere. Here I show that the coda is primarily attributed to the natural resonance in strong small-scale heterogeneity around the earthquake's hypocenter through seismic wave field modeling for 1D heterogeneity. The natural resonance is evolved from the low frequency resonance (LFR) in transient regime and is an emergent phenomenon that occurs in steady state regime. Its resonance frequency decreases with increasing heterogeneous scale, impedance contrast, or random heterogeneous scale and velocity fluctuations; its intensity diminishes with decreasing impedance contrast or increasing random heterogeneous scale and velocity fluctuations.
Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis
Creators: name: Gruner, Melanie
name: Moncsek, Anja
name: Rödiger, Stefan
name: Kühnhardt, Dagmar
name: Feist, Eugen
name: Stohwasser, Ralf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background PA28γ (also known as Ki, REG gamma, PMSE3), a member of the ubiquitin-and ATP-independent proteasome activator family 11S, has been proved to show proteasome-dependent and -independent effects on several proteins including tumor suppressor p53, cyclin-dependent kinase inhibitor p21 and steroid receptor co-activator 3 (SCR-3). Interestingly, PA28γ is overexpressed in pathological tissue of various cancers affecting e. g. breast, bowl and thyroids. Furthermore, anti-PA28γ autoantibodies have been linked to several autoimmune disorders. The aim of this study was to develop and evaluate a novel and sensitive PA28γ sandwich ELISA for the quantification of PA28γ serum levels in patients with cancer and autoimmune diseases for diagnostic and prognostic purposes. Methods PA28γ-specific polyclonal antibodies and recombinant His-tagged PA28γ were purified and used to develop a sandwich ELISA for the detection of circulating PA28γ. With this new assay, PA28γ serum levels of patients with various cancers, rheumatoid arthritis (RA), Sjögren’s syndrome (SS), adult-onset Still’s disease (AOSD) and different connective- tissue diseases (CTD) were compared with healthy control subjects. Anti-PA28γ autoantibodies were additionally confirmed using a newly developed microbead assay. Results The developed PA28γ sandwich ELISA showed a high specificity with a detection limit of 3 ng/ml. A significant up-regulation of circulating PA28γ was detected in the sera of patients with cancer, RA, SS and CTD. A significant correlation was observed dependent on age as well as anti-PA28γ autoantibody levels with circulating PA28γ protein levels. Furthermore, PA28γ serum levels showed a correlation with disease activity in patients with RA under treatment with the T-cell directed biological compound abatacept according to disease activity score 28 (DAS28) and erythrocyte sedimentation rate (ESR). Conclusion The application of PA28γ as a novel biomarker for diagnostic purposes of a specific disease is limited, since elevated levels were observed in different disorders. However, the correlation with disease activity in patients with RA suggests a prognostic value, which needs to be addressed by further studies. Therefore our results show that PA28γ is a useful marker which should be included in studies related to novel treatments, e.g. abatacept
Structural studies of anti-tumour antibody R24.
Creators: name: Kaminski, Marcin Jerzy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: The murine monoclonal antibody R24 and mouse-human Fv-IgG1($\kappa)$ chimeric monoclonal antibody chR24 are specific for the cell surface tumour antigen disialoganglioside GD3. X-ray diffraction and surface plasmon resonance experiments have been employed to study the mechanism of "homophilic binding" in which molecules of R24 recognize and bind to other molecules of R24 through the heavy chain variable domains. The relationship between GD3-binding and the homophilic-binding domain, and the mechanism of the behaviour of chR24 mutants has also been investigated. R24 exhibits strong binding to GD3-bearing liposomes, with no apparent binding saturation, while chR24 binding is much weaker. This suggests that cooperative interactions involving antibody constant regions contribute to R24 binding to membrane-anchored GD3. The crystal structures of the Fabs from R24 and chR24 reveal the mechanism for homophilic binding and confirm that the homophilic and antigen-binding idiotopes are distinct. The homophilic binding idiotope is formed largely by an antiparallel $\beta$-sheet dimerization between the H2 CDR loops of two Fabs, while the antigen-binding idiotope is a pocket formed by the three CDR loops of the heavy chain. The conformation of the antigen-binding site explains why mutations of specific residues blocks GD3-binding. Comparison with known structures of other Fabs shows that the formation of homophilic dimers requires the presence of a canonical conformation for the H2 CDR in conjunction with side chain participation. The relative positions of the homophilic and antigen binding sites allows for a lattice of R24 antibodies to be constructed, which is stabilized by the presence of the cell membrane. The model provides for the selective recognition cells which overexpress GD3 on the membrane surface by R24.
TV and broadband: Innovative applications for people with disabilities
Creators: name: Slater, Jim
name: Lindström, Jan-Ingvar
name: Astbrink, Gunela
Publisher: name: Swinburne
Year: 2024

description: Innovative applications of TV and broadband will be two key enablers for people with disabilities. The National Broadband Network offers exceptional opportunities for this to occur. This paper outlines international projects focusing on the use of digital TV as a form of interactive communications tool and also how combining broadcasting and broadband will offer enhanced services to people with disabilities. Usability and user involvement are key success factors.
Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors
Creators: name: Walter, Robert Fred Henry
name: Vollbrecht, Claudia
name: Christoph, Daniel
name: Werner, Robert
name: Schmeller, Jan
name: Flom, Elena
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: NanoString
subject: next-generation sequencing
subject: biomarkers
subject: personalized therapy
subject: lung cancer
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Lung cancer is the leading cause of cancer-related deaths worldwide. 25% show neuroendocrine differentiation (typical/atypical carcinoids, large-/small-cell neuroendocrine carcinomas). Carcinoids present with long survival rates, but metastatic carcinoids correlate with decreased survival and are commonly insensitive to standard chemotherapy or radiation. Therefore, novel therapeutic strategies are urgently needed. Material and methods: 70 representative tumor specimens were used for next-generation sequencing analysis of 14 genes related to therapy response. Additionally, mRNA-expression profiles of 60 matching samples were determined for 13 selected drug targets by using the NanoString nCounter technology. Results: A number of features known to sensitize tumors for different targeted therapies could be identified, which hopefully improve the clinical management of this subgroup of lung neoplasias. In particular, EGFR expression was observed in the investigated tumors in a noteworthy manner. Additionally, MDM2 was strongly expressed in the majority of all samples whereas the expression of its physiological inhibitor, CDKN2A, was nearly absent in all low-grade tumors. TP53 showed a high frequency of variants in high-grade tumors but mutations were rare in carcinoids. Conclusion: Based on our results, therapeutic approaches with MDM2-inhibitors and monoclonal anti-EGFR antibodies may be promising in pulmonary carcinoid tumors.
Polarization observations of 20 millisecond pulsars
Creators: name: Yan, W. M.
name: Manchester, R. N.
name: van Straten, Willem
name: Reynolds, J. E.
name: Hobbs, G.
name: Wang, N.
name: Bailes, Matthew
name: Bhat, N. D. R.
name: Burke-Spolaor, S.
name: Champion, D. J.
name: Coles, W. A.
name: Hotan, A. W.
name: Khoo, J.
name: Oslowski, Stefan
name: Sarkissian, J. M.
name: Verbiest, J. P. W.
name: Yardley, D. R. B.
Publisher: name: Swinburne
Year: 2024

description: Polarization profiles are presented for 20 millisecond pulsars that are being observed as part of the Parkes Pulsar Timing Array project. The observations used the Parkes multibeam receiver with a central frequency of 1369MHz and the Parkes digital filter bank pulsar signal-processing system PDFB2. Because of the large total observing time, the summed polarization profiles have very high signal-to-noise ratios and show many previously undetected profile features. 13 of the 20 pulsars show emission over more than half of the pulse period. Polarization variations across the profiles are complex, and the observed position angle variations are generally not in accord with the rotating vector model for pulsar polarization. Nevertheless, the polarization properties are broadly similar to those of normal (non-millisecond) pulsars, suggesting that the basic radio emission mechanism is the same in both classes of pulsar. The results support the idea that radio emission from millisecond pulsars originates high in the pulsar magnetosphere, probably close to the emission regions for high-energy X-ray and gamma-ray emission. Rotation measures were obtained for all 20 pulsars, eight of which had no previously published measurements.
Understanding the experiences for female national athletes of a team sport in a centralized training camp.
Creators: name: Farres, Laura G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Women's Studies.

description: The purpose of the current study was to describe how eight female national athletes of one team sport experienced the activity of a six-week centralized training camp. Specifically, the following research questions guided the study: (a) what was the process of the experience for each of these athletes and what strategies do they use to progress through the centralized camp; (b) how did the athletes experience the various contexts of their lives during the centralized camp and what strategies did they use to progress through them; and (c) how did athletes come to understand and take into account their experience? What did athletes learn from the experience? This inquiry was guided by a social constructivist perspective informed by feminist theory in sport. The eight participants were interviewed using an in-depth phenomenological approach. Each participant was taken through a series of three in-depth 90-minute interviews and asked to describe her experience at the six week centralized training camp. Analysis occurred on two levels---individual profiles and shared experiences. The findings are discussed in terms of the research questions. With respect to process of the experience and the strategies employed to progress through the camp, social and organizational factors played a fundamental role in the experience of the participants. Moreover, the coping strategies selected by the participants' were related to their cognitive appraisal of the person-environment relationship. With respect to the various contexts of their lives and the strategies employed, the participants approached the centralized training camp by taking steps to minimize the distractions from their outside world before attending the camp. Further, during the camp, participants had limited contact with individuals outside the camp environment, followed routines and activities, and sought social support from teammates to maintain and achieve their desired focus while in camp. Finally, with respect to the meaning of the experience and the lessons arising, the participants highlighted numerous issues of both a positive and negative nature. The camp meant opportunities for personal growth; mastery experiences; feelings of anger, disappointment, and failure; and questions of continued involvement in the sport. In addition, participants stressed the meaning of the centralized training camp experience with respect to the opportunities to interact and share experiences with others and develop positive friendships and memories. The findings are also discussed in terms of initiatives for educating national team athletes, coaches and organizations on preparation for, and implementation of, centralized training camps. (Abstract shortened by UMI.)
Assessing quality of maternity care in Hungary: expert validation and testing of the mother-centered prenatal care (MCPC) survey instrument
Creators: name: Rubashkin, Nicholas
name: Szebik, Imre
name: Baji, Petra
name: Szántó, Zsuzsa
name: Susánszky, Éva
name: Vedam, Saraswathi
Publisher: name: BioMed Central
Year: 2017

description: Instruments to assess quality of maternity care in Central and Eastern European (CEE) region are scarce, despite reports of poor doctor-patient communication, non-evidence-based care, and informal cash payments. We validated and tested an online questionnaire to study maternity care experiences among Hungarian women. Methods Following literature review, we collated validated items and scales from two previous English-language surveys and adapted them to the Hungarian context. An expert panel assessed items for clarity and relevance on a 4-point ordinal scale. We calculated item-level Content Validation Index (CVI) scores. We designed 9 new items concerning informal cash payments, as well as 7 new “model of care” categories based on mode of payment. The final questionnaire (N = 111 items) was tested in two samples of Hungarian women, representative (N = 600) and convenience (N = 657). We conducted bivariate analysis and thematic analysis of open-ended responses. Results Experts rated pre-existing English-language items as clear and relevant to Hungarian women’s maternity care experiences with an average CVI for included questions of 0.97. Significant differences emerged across the model of care categories in terms of informal payments, informed consent practices, and women’s perceptions of autonomy. Thematic analysis (N = 1015) of women’s responses identified 13 priority areas of the maternity care experience, 9 of which were addressed by the questionnaire. Conclusions We developed and validated a comprehensive questionnaire that can be used to evaluate respectful maternity care, evidence-based practice, and informal cash payments in CEE region and beyond.
Rotation measure variations for 20 millisecond pulsars
Creators: name: Yan, W. M.
name: Manchester, R. N.
name: Hobbs, G.
name: van Straten, Willem
name: Reynolds, J. E.
name: Wang, N.
name: Bailes, Matthew
name: Bhat, N. D. R.
name: Burke-Spolaor, S.
name: Champion, D. J.
name: Chaudhary, A.
name: Coles, W. A.
name: Hotan, A. W.
name: Khoo, J.
name: Oslowski, Stefan
name: Sarkissian, J. M.
name: Yardley, D. R. B.
Publisher: name: Swinburne
Year: 2024

description: We report on variations in the mean position angle of the 20 millisecond pulsars being observed as part of the Parkes Pulsar Timing Array (PPTA) project. It is found that the observed variations are dominated by changes in the Faraday rotation occurring in the Earth's ionosphere. Two ionospheric models are used to correct for the ionospheric contribution and it is found that one based on the International Reference Ionosphere gave the best results. Little or no significant long-term variation in interstellar RM was found with limits typically about 0.1 rad m-2 yr-1 in absolute value. In a few cases, apparently significant RM variations over timescales of a few 100 days or more were seen. These are unlikely to be due to localised magnetised regions crossing the line of sight since the implied magnetic fields are too high. Most probably they are statistical fluctuations due to random spatial and temporal variations in the interstellar electron density and magnetic field along the line of sight.
title: Department of Transportation News Releases for August 1968
Creators: name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1968
Subjects: classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/96618
subject: History
classificationCode: https://trt.trb.org/term/88537
subject: Management
classificationCode: https://trt.trb.org/term/91975
subject: Organizations
classificationCode: https://trt.trb.org/term/97447
subject: News

description: Department of Transportation News Releases for August 1968.
The High Time Resolution Universe Pulsar Survey - II. Discovery of five millisecond pulsars
Creators: name: Bates, S. D.
name: Bailes, Matthew
name: Bhat, N. D.R.
name: Burgay, M.
name: Burke-Spolaor, S.
name: D'Amico, N.
name: Jameson, A.
name: Johnston, S.
name: Keith, M. J.
name: Kramer, M.
name: Levin, L.
name: Lyne, A.
name: Milia, S.
name: Possenti, A.
name: Stappers, B.
name: van Straten, Willem
Publisher: name: Swinburne
Year: 2024

description: We present the discovery of five millisecond pulsars found in the mid-Galactic latitude portion of the High Time Resolution Universe (HTRU) survey. The pulsars have rotational periods from ∼2.3 ms to ∼7.5 ms, and all are in binary systems with orbital periods ranging from ∼0.3 to ∼150 d. In four of these systems, the most likely companion is a white dwarf, with minimum masses of ∼0.2 M⊙. The other pulsar, J1731−1847, has a very low mass companion and exhibits eclipses and is thus a member of the ‘black widow’ class of pulsar binaries. These eclipses have been observed in bands centred near frequencies of 700, 1400 and 3000 MHz, from which measurements have been made of the electron density in the eclipse region. These measurements have been used to examine some possible eclipse mechanisms. The eclipse and other properties of this source are used to perform a comparison with the other known eclipsing and ‘black widow’ pulsars. These new discoveries occupy a short-period and high-dispersion measure (DM) region of parameter space, which we demonstrate is a direct consequence of the high time and frequency resolution of the HTRU survey. The large implied distances to our new discoveries make observation of their companions unlikely with both current optical telescopes and the Fermi Gamma-ray Space Telescope. The extremely circular orbits make any advance of periastron measurements highly unlikely. No relativistic Shapiro delays are obvious in any of the systems although the low flux densities would make their detection difficult unless the orbits were fortuitously edge-on.
title: Department of Transportation News Releases for May 1969
Creators: name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1969
Subjects: classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/96618
subject: History
classificationCode: https://trt.trb.org/term/88537
subject: Management
classificationCode: https://trt.trb.org/term/91975
subject: Organizations
classificationCode: https://trt.trb.org/term/97447
subject: News

description: Department of Transportation News Releases for May 1969.
Characterization of epitaxial cadmium telluride and lead telluride layers grown by R.F. magnetron sputtering.
Creators: name: Mukherjee, Goutam.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1989
Subjects: subject: Physics, Condensed Matter.

description: Sputter-deposited heteroepitaxial layers of (100) CdTe $\Vert$ (100) KBr prepared at growth temperatures of 300-325$\sp\circ$C are found to be p-type with high dark resistivities on the order of 2 $\times$ 10$\sp5$ ohm-cm. The epilayers are highly photoconducting. The photoconductivity $\sigma\sb{ph}$ (expressed as $\sigma\sb{ph} \propto f\sp{\gamma}$) is observed to exhibit a sublinear ($\gamma$ $\prec$ 1) dependence on illumination intensity f. Photo-Hall effect measurements show that the photoconductivity is due to change in carrier concentration and not due to any enhancement in the carrier mobility. Moreover, the photocurrent is carried by holes. Hall measurements on sputter-deposited epitaxial PbTe films have confirmed that samples prepared at high growth temperatures are n-type and those grown at low substrate temperatures are p-type, irrespective of the substrate bias applied during growth. The low temperature mobility values in the sputter-deposited samples are found to be limited by a temperature-independent neutral impurity scattering mechanism. One of the features of heteroepitaxial growth is the existence of a large density of structural defects at the interface due to lattice mismatch. (Abstract shortened by UMI.)
The High Time Resolution Universe Pulsar Survey - III. Single-pulse searches and preliminary analysis
Creators: name: Burke-Spolaor, S.
name: Bailes, Matthew
name: Johnston, S.
name: Bates, S. D.
name: Bhat, N. D.R.
name: Burgay, M.
name: D'Amico, N.
name: Jameson, A.
name: Keith, M. J.
name: Kramer, M.
name: Levin, L.
name: Milia, S.
name: Possenti, A.
name: Stappers, B.
name: van Straten, Willem
Publisher: name: Swinburne
Year: 2024

description: We present the search methods and initial results for transient radio signals in the High Time Resolution Universe (HTRU) survey. The HTRU survey's single-pulse search, the software designed to perform the search and a determination of the HTRU survey's sensitivity to single pulses are described. Initial processing of a small fraction of the survey has produced 11 discoveries, all of which are sparsely emitting neutron stars, as well as provided confirmation of two previously unconfirmed neutron stars. Most of the newly discovered objects lie in regions surveyed previously, indicating both the improved sensitivity of the HTRU survey observing system and the dynamic nature of the radio sky. The cycles of active and null states in nulling pulsars, rotating radio transients (RRATs) and long-term intermittent pulsars are explored in the context of determining the relationship between these populations and of the sensitivity of a search to the various radio-intermittent neutron star populations. This analysis supports the case that many RRATs are in fact high-null-fraction pulsars (i.e. with a null fraction of ≳0.95) and indicates that intermittent pulsars appear distinct from nulling pulsars in their activity cycle time-scales. We find that in the measured population, there is a deficit of pulsars with typical emission time-scales greater than ∼300 s that is not readily explained by selection effects. The HTRU low-latitude survey will be capable of addressing whether this deficit is physical. We predict that the HTRU survey will explore pulsars with a broad range of nulling fractions (up to and beyond 0.999), and at its completion is likely to increase the currently known RRATs by a factor of more than 2.
title: Department of Transportation News Releases for September 1972
Creators: name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1972
Subjects: classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/96618
subject: History
classificationCode: https://trt.trb.org/term/88537
subject: Management
classificationCode: https://trt.trb.org/term/91975
subject: Organizations
classificationCode: https://trt.trb.org/term/97447
subject: News

description: Department of Transportation News Releases for September 1972.
Contribution of genetic variants to orofacial clefts in African populations
Creators: name: Awotoye, Waheed O
Publisher: name: University of Iowa
Year: 2024
Subjects: subject: African population
subject: genome-wide association studies
subject: next-generation sequencing
subject: Orofacial clefts
subject: pathogenic mutations
subject: public abstract
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: Orofacial clefts (OFCs) are the most common craniofacial birth defect and epidemiological studies report their huge burden on public health. Genetic risk factors contributions to the OFCs etiopathogenesis have long been investigated in other populations but the African population is understudied. Findings from these studies could only explain 25% OFCs genetic risk factors. Risk loci which have been associated with OFCs are population specific and the high genetic variation within the African genome provide opportunity for novel discovery. In order to identify new genetic risk factors in OFCs developmental pathogenesis we employed novel analytical approaches. First, using the African nonsyndromic OFCs (nsOFCs) common polymorphisms data we conducted a genome-wide association studies testing the effect of Gene-by-sex (GxSex) interaction on the risk of nsOFCs. We identified a novel risk locus on chromosome 8p22 which is in topologically associating domain (TAD) with craniofacially expressed and enriched genes during embryonic development. Whole-exome sequencing analysis found pathogenic variants of some of these genes in nsOFCs cohort providing further evidence of these genes in cleft pathogenesis.
description: Secondly, we conducted whole-genome sequencing analysis of nsCL/P African case-parent trios in order to identify novel pathogenic mutations. We identified pathogenic de-novo mutations (DNMs) in genes with evidence of their roles in craniofacial development and OFCs pathogenesis. Some of these genes are enriched in neural crest migration, lip, and palate developmental process.
description: In addition to these DNMs, we identified pathogenic mutations in a novel cleft candidate gene, AFDN. Computational analyses suggest that the mutations in Afadin affect its interactions with cleft candidate gene products, notable among them being nectins. Perturbations of these interactions have been reported in syndromic cleft.
description: In summary, we employed several approaches to investigate the African genome for genetic risks to nsOFCs pathogenesis and found novel risk factors and plausible mechanism involved which could serve as bedrock for effective therapeutic intervention targeted at prevention. Additionally, these findings provide further evidence supporting the need to increase genetic studies in the African population.
The Parkes Observatory Pulsar Data Archive
Creators: name: Hobbs, G.
name: Miller, D.
name: Manchester, R. N.
name: Dempsey, J.
name: Chapman, J. M.
name: Khoo, J.
name: Applegate, J.
name: Bailes, Matthew
name: Bhat, N. D. R.
name: Bridle, R.
name: Borg, A.
name: Brown, A.
name: Burnett, C.
name: Camilo, F.
name: Cattalini, C.
name: Chaudhary, A.
name: Chen, R.
name: D'Amico, N.
name: Kedziora-Chudczer, L.
name: Cornwell, T.
name: George, R.
name: Hampson, G.
name: Hepburn, M.
name: Jameson, A.
name: Keith, M.
name: Kelly, T.
name: Kosmynin, A.
name: Lenc, E.
name: Lorimer, D.
name: Love, C.
name: Lyne, A.
name: McIntyre, V.
name: Morrissey, J.
name: Pienaar, M.
name: Reynolds, J.
name: Ryder, G.
name: Sarkissian, J.
name: Stevenson, A.
name: Treloar, A.
name: van Straten, Willem
name: Whiting, M.
name: Wilson, G.
Publisher: name: Swinburne
Year: 2024

description: The Parkes pulsar data archive currently provides access to 144044 data files obtained from observations carried out at the Parkes observatory since the year 1991. Around 105 files are from surveys of the sky, the remainder are observations of 775 individual pulsars and their corresponding calibration signals. Survey observations are included from the Parkes 70cm and the Swinburne Intermediate Latitude surveys. Individual pulsar observations are included from young pulsar timing projects, the Parkes Pulsar Timing Array and from the PULSE@Parkes outreach program. The data files and access methods are compatible with Virtual Observatory protocols. This paper describes the data currently stored in the archive and presents ways in which these data can be searched and downloaded.
Towards knowledge-base systems for translators.
Creators: name: Miller, David R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Language, General.

description: The aim of this thesis is twofold. First, on a theoretical level, it aims to examine knowledge from two standpoints: translation theory and artificial intelligence (AI). Second, on a more practical level, it aims to explore the applicability of research in the branch of AI known as knowledge engineering to the eventual development of knowledge-base systems for translators (KBSTs). The "opaqueness" of a text, or its resistance to understanding, often reflects a difference between the translator's knowledge profile and the knowledge profile that the author of the original text assumed for his reader. Consequently, knowledge maximization can be considered a viable translation strategy for countering opaqueness. When translators work without sufficient knowledge, they are forced to fall back on a "transcoding" or word-bound approach, which, although it sometimes produces acceptable results, is likely to produce an unidiomatic text and is much more prone to serious translation errors. The goal of a KBST, therefore, must be to provide enough knowledge to allow the translator to engage his "interpretative" or meaning-based mode of translating. A knowledge-management system developed at the University of Ottawa called CODE (Conceptually Oriented Description Environment) offers a knowledge acquisition and retrieval environment that can be adapted to the needs of translators. A knowledge base on stock-market options, called optionCODE, was developed by the present author using the system to explore the principle and problems of designing and using KBSTs. An informal experiment demonstrated that translators using this knowledge base as their sole source of knowledge to translate a text concerning options performed as well as, if not better than, a translator using traditional sources. (Abstract shortened by UMI.)
Dynamics and heterogeneity of brain damage in multiple sclerosis
Creators: name: Kotelnikova, Ekaterina
name: Kiani, Narsis A.
name: Abad, Elena
name: Martinez-Lapiscina, Elena H.
name: Andorra, Magi
name: Paul, Friedemann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous disease. We established a hypothesis whereby the variability in the course of MS is driven by the very same pathogenic mechanisms responsible for the disease, the autoimmune attack on the CNS that leads to chronic inflammation, neuroaxonal degeneration and remyelination. We propose that each of these processes acts more or less severely and at different times in each of the clinical subgroups. To test this hypothesis, we developed a mathematical model that was constrained by experimental data (the expanded disability status scale [EDSS] time series) obtained from a retrospective longitudinal cohort of 66 MS patients with a long-term follow-up (up to 20 years). Moreover, we validated this model in a second prospective cohort of 120 MS patients with a three-year follow-up, for which EDSS data and brain volume time series were available. The clinical heterogeneity in the datasets was reduced by grouping the EDSS time series using an unsupervised clustering analysis. We found that by adjusting certain parameters, albeit within their biological range, the mathematical model reproduced the different disease courses, supporting the dynamic CNS damage hypothesis to explain MS heterogeneity. Our analysis suggests that the irreversible axon degeneration produced in the early stages of progressive MS is mainly due to the higher rate of myelinated axon degeneration, coupled to the lower capacity for remyelination. However, and in agreement with recent pathological studies, degeneration of chronically demyelinated axons is not a key feature that distinguishes this phenotype. Moreover, the model reveals that lower rates of axon degeneration and more rapid remyelination make relapsing MS more resilient than the progressive subtype. Therefore, our results support the hypothesis of a common pathogenesis for the different MS subtypes, even in the presence of genetic and environmental heterogeneity. Hence, MS can be considered as a single disease in which specific dynamics can provoke a variety of clinical outcomes in different patient groups. These results have important implications for the design of therapeutic interventions for MS at different stages of the disease.
title: Department of Transportation News Releases for February 1971
Creators: name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1971
Subjects: classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/96618
subject: History
classificationCode: https://trt.trb.org/term/88537
subject: Management
classificationCode: https://trt.trb.org/term/91975
subject: Organizations
classificationCode: https://trt.trb.org/term/97447
subject: News

description: Department of Transportation News Releases for February 1971.
Register in Khmer: The laryngeal specification of pharyngeal expansion.
Creators: name: Meechan, Marjory Ellen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Language, Linguistics.

description: The theory of "feature geometry" is an attempt to organize a finite set of features into a universal hierarchy. This hierarchy has the desirable effect of constraining phonological rules and representations by determining which sets of features may operate together as a natural class and which may not. This thesis investigates pharyngeal expansion as a distinctive feature of Khmer vowels and its representation with respect to this universal hierarchy. Previous work on Khmer has suggested that the feature of Khmer vowels known as "register" is phonetically articulated as pharyngeal expansion and therefore should be phonologically represented with the feature (Advanced Tongue Root), henceforth (ATR). Current feature hierarchy proposals have argued that the feature (ATR) is a dependent of the (Place) tier, under which are found features which relate to articulatory gestures of the tongue. The hypothesis advanced here is that "register" involves a lowered larynx and therefore, should be represented by a feature such as (Lowered Larynx), dependent on the (Laryngeal) tier. In order to investigate this hypothesis, the phonological rules of register harmony in Khmer are analyzed. The distinctive features and structures of Khmer are determined from an examination of consonant and vowel co-occurrence restrictions and nasal assimilation. It is shown that the class of segments which block register harmony must be specified with laryngeal features. Therefore, it is concluded that register is phonologically laryngeal. (Abstract shortened by UMI.)
Changes of 25-OH-Vitamin D during Overwintering at the German Antarctic Stations Neumayer II and III
Creators: name: Steinach, Mathias
name: Kohlberg, Eberhard
name: Maggioni, Martina Anna
name: Mendt, Stefan
name: Opatz, Oliver
name: Stahn, Alexander
name: Tiedemann, Josefine
name: Gunga, Hanns-Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Purpose Humans in Antarctica face different environmental challenges, such as low ultra-violet radiation, which is crucial for vitamin D production in humans. Therefore we assessed changes in 25-OH-vitamin D serum concentration during 13 months of overwintering at the German Stations Neumayer II and III (2007–2012). We hypothesized that (i) 25-OH-vitamin D serum concentration would significantly decrease, (ii) changes would be affected by age, gender, baseline (i.e. pre-overwintering) fat mass, baseline 25-OH-vitamin D serum concentration, and station residence, and (iii) our results would not differ from similar previous studies in comparable high latitudes. Materials & Methods 25-OH-vitamin D serum concentrations were determined before, after, and monthly during the campaigns from venous blood samples of n = 43 participants (28 men, 15 women). Baseline fat mass was determined via bio impedance analysis and body plethysmography. Data were analyzed for change over time, dependency on independent parameters, and after categorization for sufficiency (>50nmol/l), insufficiency (25-50nmol/l), and deficiency (<25nmol/l). Results were compared with data from similar previous studies. Results We found a significant decrease of 25-OH-vitamin D with dependency on month. Age, gender, fat mass, and station residence had no influence. Only baseline 25-OH-vitamin D serum concentrations significantly affected subsequent 25-OH-vitamin D values. Conclusions Overwinterings at the Antarctic German research stations Neumayer II and III are associated with a decrease in 25-OH-vitamin D serum concentrations, unaffected by age, gender, baseline fat mass, and station residence. Higher baseline vitamin D serum concentrations might protect from subsequent deficiencies. Residence at the Neumayer Stations may lead to lower vitamin D serum concentrations than found in other comparable high latitudes.