Additional file 1 of Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis
Creators: name: Al-Waeli, Haider
name: Reboucas, Ana Paula
name: Mansour, Alaa
name: Morris, Martin
name: Tamimi, Faleh
name: Nicolau, Belinda
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1. Systematic review and meta-analysis registered protocol in SYRCLE website: https://www.radboudumc.nl/en/research/technology-centers/animal-research-facility/systematic-review-center-for-laboratory-animal-experimentation/protocols NSAIDs effect on bone healing after bone fracture in animal models. Table S2. Search strategy. Table S3. SYRCLE’s tool for assessing the risk of bias (Hooijman et al 2014) (1). Table S4. Study characteristics. Table S5. Subgroup analysis by species regarding the effect of NSAID administration vs control on maximum force to fracture outcome. Table S6. Subgroup analysis by sex regarding the effect of NSAID administration vs control on maximum force to fracture outcome. Table S7. Subgroup analysis by age regarding the effect of NSAID administration vs control on maximum force to fracture outcome (1= &lt;8 wks, 2=8-16wks, &gt;16wks, 4=not mentioned). Table S8. Subgroup analysis by type pf NSAID regarding the effect of NSAID administration vs control on maximum force to fracture outcome. Table S9. Subgroup analysis by time point regarding the effect of NSAID administration vs control on maximum force to fracture outcome (1=&lt;21days, 2=21-48days, 3=&gt;48days). Table S10. Subgroup analysis by bone fracture site regarding the effect of NSAID administration vs control on maximum force to fracture outcome. Table S11. Subgroup analysis by species regarding the effect of NSAID administration vs control on stiffness to fracture outcome. Table S12. Subgroup analysis by sex regarding the effect of NSAID administration vs control on stiffness to fracture outcome. Table S13. Subgroup analysis by age regarding the effect of NSAID administration vs control on stiffness to fracture outcome (1= &lt;8 wks, 2=8-16wks, &gt;16wks, 4=not mentioned). Table S14. Subgroup analysis by type of NSAID regarding the effect of NSAID administration vs control on stiffness to fracture outcome. Table S15. Subgroup analysis by type of time point regarding the effect of NSAID administration vs control on stiffness to fracture outcome (1=&lt;21days, 2=21-48days, 3=&gt;48days). Table S16. Subgroup analysis by bone fracture site regarding the effect of NSAID administration vs control on stiffness to fracture outcome. Table S17. Subgroup analysis by species regarding the effect of NSAID administration vs control on work to failure outcome. Table S18. Subgroup analysis by sex regarding the effect of NSAID administration vs control on work to failure outcome. Table S19. Subgroup analysis by age regarding the effect of NSAID administration vs control on work to failure outcome (1= &lt;8 wks, 2=8-16wks, &gt;16wks, 4=not mentioned). Table S20. Subgroup analysis by type of NSAID regarding the effect of NSAID administration vs control on work to failure outcome. Table S21. Subgroup analysis by time point regarding the effect of NSAID administration vs control on work to failure outcome (1=&lt;21days, 2=21-48days, 3=&gt;48days). Table S22. Subgroup analysis by bone fracture site the effect of NSAID administration vs control on work to failure outcome. Table S23. Subgroup analysis by species the effect of NSAID administration vs control on histomorphometric outcome. Table S24. Subgroup analysis by sex the effect of NSAID administration vs control on histomorphometric outcome. Table S25. Subgroup analysis by age the effect of NSAID administration vs control on histomorphometric outcome (1= &lt;8 wks, 2=8-16wks, &gt;16wks, 4=not mentioned). Table S26. Subgroup analysis by type of NSAID the effect of NSAID administration vs control on histomorphometric outcome. Table S27. Subgroup analysis by time point the effect of NSAID administration vs control on histomorphometric outcome (1=&lt;21days, 2=21-48days, 3=&gt;48days). Table S28. Subgroup analysis by bone fracture site the effect of NSAID administration vs control on histomorphometric outcome.