cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(500717) Julia Sarah Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq
Creators: name: Simon, J.M.
name: Wolter, J.M.
name: Salazar, G.
name: Paranjape, S.R.
name: Zylka, M.J.
Publisher: name: Nature Publishing Group
Year: 2019

description: We previously used RNA-seq to identify chemicals whose effects on neuronal gene expression mimicked transcriptional signatures of autism, aging, and neurodegeneration. However, this approach was costly and time consuming, which limited our study to testing a single chemical concentration on mixed sex cortical neuron cultures. Here, we adapted a targeted transcriptomic method (RASL-seq, similar to TempO-seq) to interrogate changes in expression of a set of 56 signature genes in response to a library of 350 chemicals and chemical mixtures at four concentrations in male and female mouse neuronal cultures. This enabled us to replicate and expand our previous classifications, and show that transcriptional responses were largely equivalent between sexes. Overall, we found that RASL-seq can be used to accelerate the pace at which chemicals and mixtures that transcriptionally mimic autism and other neuropsychiatric diseases can be identified, and provides a cost-effective way to quantify gene expression with a panel of marker genes.
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
Creators: name: Ocasio, J.
name: Malawsky, D.
name: Stein, L.D.
name: Taylor, M.D.
name: Zylka, M.J.
name: Vladoiu, M.
name: Gershon, T.R.
name: Vibhakar, R.
name: Simon, J.M.
name: Rosen, E.P.
name: Dismuke, T.
name: Zhang, J.
name: Loo, L.
name: Wilhelmsen, K.
name: Sokolsky, M.
name: El-Hamamy, I.
name: Hwang, D.
name: Weir, S.J.
name: Babcock, B.
name: Saulnier, O.
name: Northcott, P.A.
name: Smith, K.S.
name: Colaneri, A.
Publisher: name: Nature Research
Year: 2019

description: Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular diversity within tumors and reduced lineage commitment can undermine targeted therapy by increasing the probability of treatment-resistant populations. Using single-cell RNA-seq and lineage tracing, we analyzed cellular diversity in medulloblastomas in transgenic, medulloblastoma-prone mice, and responses to the SHH-pathway inhibitor vismodegib. In untreated tumors, we find expected stromal cells and tumor-derived cells showing either a spectrum of neural progenitor-differentiation states or glial and stem cell markers. Vismodegib reduces the proliferative population and increases differentiation. However, specific cell types in vismodegib-treated tumors remain proliferative, showing either persistent SHH-pathway activation or stem cell characteristics. Our data show that even in tumors with a single pathway-activating mutation, diverse mechanisms drive tumor growth. This diversity confers early resistance to targeted inhibitor therapy, demonstrating the need to target multiple pathways simultaneously.
Observation of Anderson localization in ultrathin films of three-dimensional topological insulators
Creators: name: Liao, Jian
name: Ou, Yunbo
name: Feng, Xiao
name: Yang, Shuo
name: Lin, Chaojing
name: Yang, Wenmin
name: Wu, Kehui
name: He, Ke
name: Ma, Xucun
name: Xue, Qi-Kun
name: Li, Yongqing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Anderson localization, the absence of diffusive transport in disordered systems, has been manifested as hopping transport in numerous electronic systems, whereas in recently discovered topological insulators it has not been directly observed. Here we report experimental demonstration of transition from diffusive transport in the weak antilocalization regime to variable range hopping transport in the Anderson localization regime with ultrathin (Bi$_{1-x}$Sb$_x$)$_2$Te$_3$ films. As disorder becomes stronger, negative magnetoconductivity due to the weak antilocalization is gradually suppressed, and eventually positive magnetoconductivity emerges when the electron system becomes strongly localized. This works reveals the critical role of disorder in the quantum transport properties of ultrathin topological insulator films, in which theories have predicted rich physics related to topological phase transitions.
description: 6 pages, 4 figures, to appear in PRL, supplemental material available upon request
جمع القرآن من العصر النبوي إلى العصر الحديث
Creators: name: Abouzeid, Mohamed
Publisher: name: figshare
Year: 2020
Subjects: subject: 220499 Religion and Religious Studies not elsewhere classified
subject: FOS: Philosophy, ethics and religion
subject: Religious Studies

description: أطروحة مقدمة إلى قسم التفسير وعلوم القرآن بكلية الشريعة - جامعة الكويت لنيل درجة (التخصص) الماجستير، وموضوعها تدرس نقل القرآن من العصر النبوي إلى العصر الحديث، وتناقش الشبهات المطروحة حول نقل القرآن، وتجيب عنها بصورة علمية موضوعية.A dissertation submitted to the Department of Interpretation and Qur’an Sciences at the College of Sharia - Kuwait University for a master’s degree (specialization), the topic of which studies the transfer of the Qur’an from the Prophet’s era to the modern era, and discusses the suspicions raised about the transmission of the Qur’an, and answers them in an objective scientific manner.
Group-based ranking method for online rating systems with spamming attacks
Creators: name: Gao, Jian
name: Dong, Yu-Wei
name: Shang, Mingsheng
name: Cai, Shi-Min
name: Zhou, Tao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Retrieval (cs.IR)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Ranking problem has attracted much attention in real systems. How to design a robust ranking method is especially significant for online rating systems under the threat of spamming attacks. By building reputation systems for users, many well-performed ranking methods have been applied to address this issue. In this Letter, we propose a group-based ranking method that evaluates users' reputations based on their grouping behaviors. More specifically, users are assigned with high reputation scores if they always fall into large rating groups. Results on three real data sets indicate that the present method is more accurate and robust than correlation-based method in the presence of spamming attacks.
description: 6 pages, 5 figures, 2 tables
(500718) Louisa Amelia Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Luminosity function of white dwarfs and discovery of new white dwarfs by means of Gaia EDR3 data
Creators: name: Mickaelian, Areg
name: Mikayelya, Gor
name: Abrahamyan, Hyak
name: Paronyan, Gurgen
Publisher: name: Zenodo
Year: 2022

description: The discovery of new White Dwarfs (WDs) is extremely important for understanding the kinematics and dynamics of the local stellar population. They are evolutionary signatures of the Milky Way, as most of stars pass through this evolutionary stage. Gaia’s astrometric accuracy allows more detailed studies of WDs and many other stars. We have constructed the luminosity function for McCook & Sion White Dwarf catalogue objects based on distances provided by Gaia EDR3. We have revealed among 640 First Byurakan Survey UV-excess stars objects with proper motions (PM) >10 mas/yr. Adopting 50 km/s upper limit for tangential velocities, we calculated maximum distances and absolute magnitudes and estimated luminosity types for these objects, revealing 185 probable (M > 8), 69 possible WDs (6 < M < 8) and 42 candidate subdwarfs/WDs. The Digitized First Byurakan Survey (DFBS) is more efficient for discovery of new WDs by spectral energy distribution. Using Gaia data for accurate parallaxes and distances in combination with DFBS low-dispersion spectra and additional multiwavelength data, during the pilot survey we have revealed thousands of new WDs and candidate subdwarf/WDs. Many of them are subject for studies on binarity and variability. Gaia DR3 will provide huge amount of data to confirm these WDs and reveal many more such objects.
Savons-nous vraiment ce qu'est la schizophrénie ?
Creators: name: STANKOVA, Dayana
name: PINTO, Tara
Publisher: name: Zenodo
Year: 2024

description: Notre poster vise à permettre une meilleure comprehension de la schizophrénie en tant que trouble, les mécanismes biologiques associés, la souffrance des personnes schizophrènes, le rôle du cannabis, etc.
(500721) Eleanor Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Single-cell transcriptomic analysis of mouse neocortical development
Creators: name: Loo, L.
name: Simon, J.M.
name: Zylka, M.J.
name: McCoy, E.S.
name: Anton, E.S.
name: Xing, L.
name: Niehaus, J.K.
name: Guo, J.
Publisher: name: Nature Publishing Group
Year: 2019

description: The development of the mammalian cerebral cortex depends on careful orchestration of proliferation, maturation, and migration events, ultimately giving rise to a wide variety of neuronal and non-neuronal cell types. To better understand cellular and molecular processes that unfold during late corticogenesis, we perform single-cell RNA-seq on the mouse cerebral cortex at a progenitor driven phase (embryonic day 14.5) and at birth—after neurons from all six cortical layers are born. We identify numerous classes of neurons, progenitors, and glia, their proliferative, migratory, and activation states, and their relatedness within and across age. Using the cell-type-specific expression patterns of genes mutated in neurological and psychiatric diseases, we identify putative disease subtypes that associate with clinical phenotypes. Our study reveals the cellular template of a complex neurodevelopmental process, and provides a window into the cellular origins of brain diseases.
(500715) Charles Henry Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การศึกษาการเร่งผลสัมฤทธิ์การเรียนรู้คำศัพท์ภาษาอังกฤษของนักเรียนชั้นอนุบาลปีที่ 2 โดยใช้งานสร้างสรรค์ผ่านวิธีการเล่านิทานและการปั้นดิน
Creators: name: อรภัทรกาญจน์ ชัยวัฒน์จตุพร
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2018
Subjects: Accelerated vocabulary learning achievements
Clay work
Creativity tasks,
Story telling,
การปั้นดิน
การเร่งผลสัมฤทธิ์การเรียนรู้คำศัพท์
การเล่านิทาน
งานสร้างสรรค์

description: วารสารพัฒนาการเรียนการสอน, 12, 1, 1-11
Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice
Creators: name: Zylka, M.J.
name: Bartsch, V.B.
name: Niehaus, J.K.
name: Taylor-Blake, B.
Publisher: name: Public Library of Science
Year: 2019

description: Subsets of small-diameter dorsal root ganglia (DRG) neurons detect pruritogenic (itch-causing) and algogenic (pain-causing) stimuli and can be activated or sensitized by chemical mediators. Many of these chemical mediators activate receptors that are coupled to lipid hydrolysis and diacylglycerol (DAG) production. Diacylglycerol kinase iota (DGKI) can phos-phorylate DAG and is expressed at high levels in small-diameter mouse DRG neurons. Given the importance of these neurons in sensing pruritogenic and algogenic chemicals, we sought to determine if loss of DGKI impaired responses to itch- or pain-producing stimuli. Using male and female Dgki-knockout mice, we found that in vivo sensitivity to histamine—but not other pruritogens—was enhanced. In contrast, baseline pain sensitivity and pain sensitization following inflammatory or neuropathic injury were equivalent between wild type and Dgki-/- mice. In vitro calcium responses in DRG neurons to histamine was enhanced, while responses to algogenic ligands were unaffected by Dgki deletion. These data suggest Dgki regulates sensory neuron and behavioral responses to histamine, without affecting responses to other pruritogenic or algogenic agents.
Exo-zodi modelling for the Large Binocular Telescope Interferometer
Creators: name: Kennedy, Grant M.
name: Wyatt, Mark C.
name: Bailey, Vanessa
name: Bryden, Geoffrey
name: Danchi, William C.
name: Defrère, Denis
name: Haniff, Chris
name: Hinz, Philip M.
name: Lebreton, Jèrèmy
name: Mennesson, Bertrand
name: Millan-Gabet, Rafael
name: Morales, Farisa
name: Panić, Olja
name: Rieke, George H.
name: Roberge, Aki
name: Serabyn, Eugene
name: Shannon, Andrew
name: Skemer, Andrew J.
name: Stapelfeldt, Karl R.
name: Su, Katherine Y. L.
name: Weinberger, Alycia J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Habitable zone dust levels are a key unknown that must be understood to ensure the success of future space missions to image Earth analogues around nearby stars. Current detection limits are several orders of magnitude above the level of the Solar System's Zodiacal cloud, so characterisation of the brightness distribution of exo-zodi down to much fainter levels is needed. To this end, the large Binocular Telescope Interferometer (LBTI) will detect thermal emission from habitable zone exo-zodi a few times brighter than Solar System levels. Here we present a modelling framework for interpreting LBTI observations, which yields dust levels from detections and upper limits that are then converted into predictions and upper limits for the scattered light surface brightness. We apply this model to the HOSTS survey sample of nearby stars; assuming a null depth uncertainty of 10$^{-4}$ the LBTI will be sensitive to dust a few times above the Solar System level around Sun-like stars, and to even lower dust levels for more massive stars.
description: Accepted to ApJS
(500719) William Henry Ray
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
INBG00029 - INBG00029 Bodhgaya pithipati inscription on the pedestal of the sanctum image of the Mahabodhi temple
Creators: name: Balogh, Dániel
Publisher: name: Zenodo
Year: 2020

description: Bodhgayā (बोधगया), Bihār. Inscription of pīṭhīpati ācārya Jayasena (INBG00029) on the pedestal of the sanctum image of the Mahābodhi temple (OBBG00029). Edition here that of Balogh (2020), see Concordance for bibliographic data.
title: Developing a Retention Strategy for Emiratis in the Middle Management Level in an Islamic Bank
Creators: name: AlSuwaidi, Fatima
Publisher: name: University of Liverpool Repository
Year: 2028

description: This study seeks to develop a retention strategy for an Islamic Bank in the UAE context. It was necessitated by the attrition of the middle management employee base, which made it challenging for the firm to attain its Emiratization quotas. The study explored what XYZ Bank can do to delay the exit of middle management staff and increase the probability of retaining the middle management employees, the reasons why middle management employees leaving the organization, the retention strategies which can be developed and implemented, and the anticipated challenges in implementing strategies. The study used a qualitative methodology, involving interviews and focus groups, and adopted an action research approach that was situated in a practice-based problem and co-constructed actionable knowledge. The action research involved three cycles. The first cycle involved collecting reasons for exits during from former employees, using face-to-face or online interviews. The data was analyzed to draw out themes (and their sub-themes): lack of career development opportunities, negative effects on efficiency and work–life balance, limited product portfolio, lack of innovation, feeling underutilized, traditional ways of working, fairness and culture, and limited product portfolio. The second cycle involved two rounds of focus groups, discussing the strategies and their implementation methodologies. During this phase, approaches to implementing the proposals, as well as the strategies to mitigate employee exits, were discussed. Here, methods such as mentoring, performance-cum competency-based promotions, constructive feedback, and innovation-igniting mechanisms were proposed and discussed. As a result, the study co-produced an actionable framework for retention of middle managers within the organization’s context. The final cycle focused on presenting these strategies and the actionable knowledge to the company’s top level management, thereby obtaining their feedback and usability. Overall, the study presented an informed retention strategy and developed an actionable framework that the bank could utilize to retain middle managers and ensure that the organization met its Emiratization objectives.
Free energy pathways of a Multistable Liquid Crystal Device
Creators: name: Kusumaatmaja, Halim
name: Majumdar, Apala
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The planar bistable device [Tsakonas \textit{et al., Appl. Phys. Lett.}, 2007, {\textbf{90}}, 111913] is known to have two distinct classes of stable equilibria: the diagonal and rotated solutions. We model this device within the two-dimensional Landau-de Gennes theory, with a surface potential and without any external fields. We systematically compute a special class of transition pathways, referred to as minimum energy pathways, between the stable equilibria that provide new information about how the equilibria are connected in the Landau-de Gennes free energy landscape. These transition pathways exhibit an intermediate transition state, which is a saddle point of the Landau-de Gennes free energy. We numerically compute the structural details of the transition states, the optimal transition pathways and the free energy barriers between the equilibria, as a function of the surface anchoring strength. For strong anchoring, the transition pathways are mediated by defects whereas we get defect-free transition pathways for moderate and weak anchoring. In the weak anchoring limit, we recover a cusp catastrophe situation for which the rotated state acts as a transition state connecting two different diagonal states.
(500714) William John Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The business model of the Energy Efficiency Aggregator
Creators: name: Tzani, Dimitra
name: Stavrakas, Vassilis
name: Anagnostopoulos, Filippos
Publisher: name: Zenodo
Year: 2023
Subjects: Energy efficiency
Renovation Wave
Climate changes
Refurbishment
Energy efficiency measures
Energy efficiency aggregator

description: The EE Aggregator and P4P programmes are being explored in the context of the Renovation Wave for meeting the EU’s energy efficiency targets using innovative financing and new business models. Energy efficiency is one of the main pillars of energy and environmental policy to combat the adverse impacts of climate change. Although the implementation of energy efficiency interventions in the building sector is pivotal to drive the energy transition and achieve energy policy targets, energy efficiency investments and interventions remain critically low. Financial barriers (e.g., high upfront costs, high risk, uncertainty on return of investment, etc.) have been highlighted in the literature as the main factors hindering energy efficiency interventions. The objective of this report is to analyse and explore the functions of the Energy Efficiency Aggregator. Early experience from the U.S.A. suggests that P4P programmes have been most successful when aimed at EE Aggregators rather than individual customers. An EE Aggregator is an aggregating entity that groups a sufficient number of buildings together into an energy savings portfolio. P4P schemes that make payments to aggregators appear better able to drive innovation in energy efficiency service delivery.
lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA
Creators: name: Zylka, M.J.
name: Schertzer, M.D.
name: Salazar, G.
name: Cherney, R.E.
name: Starmer, J.
name: Justice, M.
name: Ariel, P.
name: Magnuson, T.
name: Bischoff, S.R.
name: Lee, D.M.
name: Cowley, D.O.
name: Dowen, J.M.
name: Braceros, K.C.A.
name: Calabrese, J.M.
Publisher: name: Cell Press
Year: 2019

description: Long noncoding RNAs (lncRNAs) cause Polycomb repressive complexes (PRCs) to spread over broad regions of the mammalian genome. We report that in mouse trophoblast stem cells, the Airn and Kcnq1ot1 lncRNAs induce PRC-dependent chromatin modifications over multi-megabase domains. Throughout the Airn-targeted domain, the extent of PRC-dependent modification correlated with intra-nuclear distance to the Airn locus, preexisting genome architecture, and the abundance of Airn itself. Specific CpG islands (CGIs) displayed characteristics indicating that they nucleate the spread of PRCs upon exposure to Airn. Chromatin environments surrounding Xist, Airn, and Kcnq1ot1 suggest common mechanisms of PRC engagement and spreading. Our data indicate that lncRNA potency can be tightly linked to lncRNA abundance and that within lncRNA-targeted domains, PRCs are recruited to CGIs via lncRNA-independent mechanisms. We propose that CGIs that autonomously recruit PRCs interact with lncRNAs and their associated proteins through three-dimensional space to nucleate the spread of PRCs in lncRNA-targeted domains. Schertzer et al. studied relationships between long noncoding RNAs (lncRNAs) and Polycomb repressive complexes (PRCs) in mouse trophoblast stem cells. They found that genome architecture, lncRNA abundance, and CpG island DNA each play important roles in dictating the intensity of PRC-induced chromatin modifications within lncRNA target domains.
ผลของการใช้เทคนิค KWL-Plus ที่มีต่อทักษะการคิดวิเคราะห์และผลสัมฤทธิ์ทางการเรียน การเขียนย่อความ กลุ่มสาระการเรียนรู้ภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 โรงเรียนวัดพังดาน สำนักงานเขตพื้นที่การศึกษาประถมศึกษาพัทลุง เขต 1
Creators: name: พัชนีญา ด้วงชู
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2018
Subjects: Analytical Thinking Skills
KWL-Plus Technique
Prathom Suksa
Summary writing achievement in Thai Language learning area
ทักษะการคิดวิเคราะห์
ประถมศึกษา
ผลสัมฤทธิ์ทางการเรียนการเขียนย่อความภาษาไทย
เทคนิค KWL-Plus

description: วารสารพัฒนาการเรียนการสอน, 12, 1, 12-23
On the size of coset unions
Creators: name: Sambale, Benjamin
name: Tǎrnǎuceanu, Marius
Publisher: name: Dordrecht [u.a.] : Springer Science + Business Media
Year: 2022
Subjects: subject: Conjecture
subject: Subgroup covering
subject: Union of cosets
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: Let g1H1, … , gnHn be cosets of subgroups H1, … , Hn of a finite group G such that g1H1∪ … ∪ gnHn≠ G. We prove that | g1H1∪ … ∪ gnHn| ≤ γn| G| where γn< 1 is a constant depending only on n. In special cases, we show that γn= (2 n- 1 ) / 2 n is the best possible constant with this property and we conjecture that this is generally true.
(500716) Laura Taplin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The quarter median
Creators: name: Baringhaus, Ludwig
name: Grübel, Rudolf
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Asymptotic normality
subject: Consistency
subject: Equipartition
subject: Estimation of location
subject: Euclidean motion equivariance
subject: Multivariate median
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: We introduce and discuss a multivariate version of the classical median that is based on an equipartition property with respect to quarter spaces. These arise as pairwise intersections of the half-spaces associated with the coordinate hyperplanes of an orthogonal basis. We obtain results on existence, equivariance, and asymptotic normality.
On a bound of Cocke and Venkataraman
Creators: name: Sambale, Benjamin
name: Wellmann, Philipp
Publisher: name: Wien [u.a.] : Springer
Year: 2022
Subjects: subject: Finite groups
subject: Maximal order
subject: Number of elements
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: Let G be a finite group with exactly k elements of largest possible order m. Let q(m) be the product of gcd (m, 4) and the odd prime divisors of m. We show that | G| ≤ q(m) k2/ φ(m) where φ denotes Euler’s totient function. This strengthens a recent result of Cocke and Venkataraman. As an application we classify all finite groups with k< 36. This is motivated by a conjecture of Thompson and unifies several partial results in the literature.
title: Tissue regeneration in osteoarthritis: the effects of inflammatory cytokines on bioengineering strategies to repair arthritic joints
Creators: name: Williams, Emma
Publisher: name: University of Southampton
Year: 2018

description: Osteoarthritis (OA) is the most common form of arthritis worldwide. Historically, treatments for OA have been analgesics, physiotherapy, joint injections and eventually joint replacement surgery. With the advent of tissue engineering (TE), there has been considerable interest in exploiting these techniques to devise new treatments for OA. Despite the development of skeletal stem cell (SSC) constructs aimed at creating viable cartilage and bone, few studies have examined the effects of inflammatory cytokines present in OA synovial tissues, on such constructs. Here, both in vitro and in vivo approaches were used to examine the effects of cytokines on the integrity of such bone constructs.

This work confirms IL-1Î² is a key cytokine for enhancing osteogenic differentiation in OA, whereas TNFÎ± is inhibitory. OA supernatants were obtained from synovial tissue of patients undergoing hip or knee arthroplasty. Most OA supernatants produced an inhibitory effect on osteogenic differentiation in co-cultures with HBMSCs; a minority had additive osteogenic effects, consistent with a more inflammatory subtype of OA. miRNA profiles were analysed for the first time in these co-cultures, producing valuable insights into the pathways through which IL-1Î² may mediate its effects on osteogenic differentiation. Finally, ex vivo and in vivo models of bone formation, not previously used in the OA field, corroborated the findings of these in vitro studies. These data support the utility of focusing on upregulating IL1-Î² and inhibiting TNFÎ± to modify existing bone TE strategies being developed locally, for use in the future treatment of OA. Findings were similar with other cell types such as induced pluripotent stem cells, which show promise for future TE strategies. This work also validated the organotypic chick femur and subcutaneous implant models for the future testing of other bioactive factors or miRNAs for incorporation into bone TE approaches for the management of OA.
Inverse scattering theory and trace formulae for one-dimensional Schrödinger problems with singular potentials
Creators: name: Rutkevich, Sergei B.
name: Diehl, H. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Inverse scattering theory is extended to one-dimensional Schrödinger problems with near-boundary singularities of the form $v(z\to 0)\simeq -z^{-2}/4+v_{-1}z^{-1}$. Trace formulae relating the boundary value $v_0$ of the nonsingular part of the potential to spectral data are derived. Their potential is illustrated by applying them to a number of Schrödinger problems with singular potentials.
description: 12 pages, no figures, pdf-LaTeX; v3: published version, 24 pages, uses IOP style files, minor changes, introduction extended, references added
Choice of vehicle affects pyraclostrobin toxicity in mice
Creators: name: Tuttle, A.H.
name: Zylka, M.J.
name: Cooper, E.M.
name: Salazar, G.
name: Stapleton, H.M.
Publisher: name: Elsevier Ltd
Year: 2019

description: Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. In toxicity studies that were used to estimate the safety factor, pyraclostrobin was added to animal feed or to aqueous vehicles. However, foods containing residues of pyraclostrobin and other strobilurin fungicides (azoxystrobin, trifloxystrobin, fluoxastrobin) are frequently prepared in vegetable oil prior to human consumption. The primary objective of this study was to determine if pyraclostrobin dissolved in an oil-based vehicle had adverse health outcomes in mice when compared to aqueous-based vehicles. We found that pyraclostrobin does not fully dissolve in aqueous methyl cellulose (MC) or carboxymethyl cellulose (CMC), two vehicles used in industry-sponsored toxicity studies, but does fully dissolve in corn oil. Moreover, C57BL/6 mice receiving pyraclostrobin in corn oil displayed adverse health outcomes, including loss of body weight, hypothermia and diarrhea at lower doses than when added to feed or to aqueous vehicles. Our data suggest that previous studies underestimated the true toxicity of pyraclostrobin in mammals. Additional toxicity tests using oil-based vehicles are recommended to verify current safety recommendations for strobilurin fungicides.
Measuring the entanglement of analogue Hawking radiation by the density-density correlation function
Creators: name: Steinhauer, Jeff
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We theoretically study the entanglement of Hawking radiation pairs emitted by an analogue black hole. We find that this entanglement can be measured by the experimentally accessible density-density correlation function, vastly simplifying the measurement. We find that while the Hawking radiation exiting the black hole might be Planck-distributed, the correlations between the Hawking radiation and the partner particles has a distribution which is weaker but broader than Planckian. Thus, the high energy tail of the distribution of Hawking radiation should be entangled, whereas the low energy part should not be. This confirms a previous numerical study. The full Peres-Horodecki criterion is considered, as well as a simpler criterion in the stationary, homogeneous case. Our method applies to systems which are sufficiently cold that the thermal phonons can be neglected.
description: The second version has a few additional explanatory sentences. The third version has an improved introduction including additional citations
Enhanced nociception in angelman syndrome model mice
Creators: name: Taylor-Blake, B.
name: Philpot, B.D.
name: McCoy, E.S.
name: Zylka, M.J.
name: Aita, M.
name: Simon, J.M.
Publisher: name: Society for Neuroscience
Year: 2017

description: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the maternal UBE3A allele. The maternal UBE3A allele is expressed in nearly all neurons of the brain and spinal cord, whereas the paternal UBE3A allele is repressed by an extremely long antisense transcript (UBE3A-ATS). Little is known about expression of UBE3A in the peripheral nervous system, where loss of maternal UBE3A might contribute to AS phenotypes. Here we sought to examine maternal and paternal Ube3a expression in DRGs neurons and to evaluate whether nociceptive responses were affected in AS model mice (global deletion of maternal Ube3a allele; Ube3am+/p+). We found that most large-diameter proprioceptive and mechanosensitive DRG neurons expressed maternal Ube3a and paternal Ube3a-ATS. In contrast, most small-diameter neurons expressed Ube3a biallelically and had low to undetectable levels of Ube3a-ATS. Analysis of single-cell DRG transcriptomes further suggested that Ube3a is expressed monoallelically in myelinated large-diameter neurons and biallelically in unmyelinated small-diameter neurons. Behavioral responses to some noxious thermal and mechanical stimuli were enhanced in male and female AS model mice; however, nociceptive responses were not altered by the conditional deletion of maternal Ube3a in the DRG. These data suggest that the enhanced nociceptive responses in AS model mice are due to loss of maternal Ube3a in the central, but not peripheral, nervous system. Our study provides new insights into sensory processing deficits associated with AS.
(500712) William Tilbury
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Untersuchungen zur analytischen Restlebensdauerbestimmung thermisch belasteter dickwandiger Bauteile
Creators: name: Paarmann, Maria
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 620 Engineering & allied operations

description: Als Konsequenz der Energiewende folgen aus der geänderten Belastung mit z.T. steileren Transienten thermomechanische Spannungen in den dickwandigen Komponenten, welche zu einem Bauteilversagen infolge Ermüdungsrisswachstum führen können. Aus diesem Anlass erfolgte in unterschiedlichen Bauteilen die numerische Untersuchung des Risswachstums bei Abkühlprozessen im Bereich zwischen 50 und 545°C bei Abkühldauern von 180 bis 3600s. Ausgehend von diesen Ergebnissen wurden analytische Lösungen zur Spannungsintensitätsfaktorbestimmung abgeleitet und exemplarisch Restlebensdauern ermittelt.
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
Creators: name: Zylka, M.J.
name: Fragola, G.
name: Yi, J.J.
name: Paranjape, S.R.
name: Wolter, J.M.
name: Emanuele, M.J.
name: Major, M.B.
name: Walker, M.P.
name: Choudhury, R.
Publisher: name: American Society for Biochemistry and Molecular Biology Inc.
Year: 2017

description: UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3AT485A) that disrupts phosphorylation control of UBE3A activity. Through quantitative proteomics and reporter assays, we found that the UBE3AT485A protein ubiquitinates multiple proteasome subunits, reduces proteasome subunit abundance and activity, stabilizes nuclear β-catenin, and stimulates canonical Wnt signaling more effectively than wild-type UBE3A. We also found that UBE3AT485A activates Wnt signaling to a greater extent in cells with low levels of ongoing Wnt signaling, suggesting that cells with low basal Wnt activity are particularly vulnerable to UBE3AT485A mutation. Ligase-dead UBE3A did not stimulate Wnt pathway activation. Overexpression of several proteasome subunits reversed the effect of UBE3AT485A on Wnt signaling. We also observed that subunits that interact with UBE3A and affect Wnt signaling are located along one side of the 19S regulatory particle, indicating a previously unrecognized spatial organization to the proteasome. Altogether, our findings indicate that UBE3A regulates Wnt signaling in a cell context-dependent manner and that an autism-linked mutation exacerbates these signaling effects. Our study has broad implications for human disorders associated with UBE3A gain or loss of function and suggests that dysfunctional UBE3A might affect additional proteins and pathways that are sensitive to proteasome activity.
Topoisomerase 1 regulates gene expression in neurons through cleavage complex-dependent and -independent mechanisms
Creators: name: An, L.-K.
name: Philpot, B.D.
name: Lee, H.-M.
name: Mabb, A.M.
name: Zylka, M.J.
name: King, I.F.
name: Simon, J.M.
Publisher: name: Public Library of Science
Year: 2016

description: Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotecan reduces the expression of long (>100 kb) genes and unsilences the paternal allele of Ube3a in neurons. Here, we sought to evaluate overlap between TOP1cc-dependent and -independent gene regulation in neurons. To do this, we utilized Top1 conditional knockout mice, Top1 knockdown, the CRISPR-Cas9 system to delete Top1, TOP1 catalytic inhibitors that do not generate TOP1cc's, and a TOP1 mutation (T718A) that stabilizes TOP1cc's. We found that topotecan treatment significantly alters the expression of many more genes, including long neuronal genes, immediate early genes, and paternal Ube3a, when compared to Top1 deletion. Our data show that topotecan has a stronger effect on neuronal transcription than Top1 deletion, and identifies TOP1cc-dependent and -independent contributions to gene expression.
(500713) William Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Troubled Touch of Autism
Creators: name: Zylka, M.J.
name: Bartsch, V.B.
name: Tuttle, A.H.
Publisher: name: Cell Press
Year: 2016

description: A study finds that deficits in touch-sensing somatosensory neurons contribute to social interaction and anxiety phenotypes in mouse models of autism and Rett syndrome. These findings suggest that some core symptoms of autism might originate from aberrant development or function of the peripheral nervous system. A study finds that deficits in touch-sensing somatosensory neurons contribute to social interaction and anxiety phenotypes in mouse models of autism and Rett syndrome. These findings suggest that some core symptoms of autism might originate from aberrant development or function of the peripheral nervous system.
Gene length matters in neurons
Creators: name: Simon, J.M.
name: Zylka, M.J.
name: Philpot, B.D.
Publisher: name: Cell Press
Year: 2015

description: A recent study by Gabel etal. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (>100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders. A recent study by Gabel etal. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
A new approach to evaluate the leading hadronic corrections to the muon g-2
Creators: name: Calame, C. M. Carloni
name: Passera, M.
name: Trentadue, L.
name: Venanzoni, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We propose a novel approach to determine the leading hadronic corrections to the muon g-2. It consists in a measurement of the effective electromagnetic coupling in the space-like region extracted from Bhabha scattering data. We argue that this new method may become feasible at flavor factories, resulting in an alternative determination potentially competitive with the accuracy of the present results obtained with the dispersive approach via time-like data.
description: 7 pages, 3 figures. Version accepted for publication in Phys. Lett. B
Quantum corrections to inflaton dynamics, the semi-classical approach and the semi-classical limit
Creators: name: Herranen, Matti
name: Osland, Asgeir
name: Tranberg, Anders
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Computations of quantum corrections to the CMB spectrum and to scalar field dynamics during inflation very often take advantage of the "semi-classical" approach, where the metric fluctuations are simply omitted. On the other hand, a complete computation ought to take into account that the matter field perturbation and scalar metric perturbation together constitute a single physical degree of freedom. The question then naturally arises, in which sense the semi-classical approach is an approximation to the complete calculation, and whether there are specific limits where this is also a good approximation. We consider the quantum corrected dynamics of interacting scalar fields in an expanding inflationary background. We demonstrate this by explicitly computing the leading quantum radiative corrections to the evolution equation of the mean field ("condensate") and the Friedmann equations taking into account scalar perturbations of both the matter field and the metric, and when omitting the latter. We find that the two agree in the limit H << M_pl , but one is not a limit of the other. We also find that in simple models of inflation, H/M_pl is not small enough that the two approaches can be said to agree. By direct comparison, we demonstrate how to interpret the "semi-classical" approach often employed in more complex computations as a well-defined approximation, and quantify its validity.
description: Some revision and rewordings, added references. 16 pages