Mendelian randomisation study of smoking exposure in relation to breast cancer risk
Creators: name: Park, Hanla A.
name: Neumeyer, Sonja
name: Michailidou, Kyriaki
name: Bolla, Manjeet K.
name: Wang, Qin
name: Dennis, Joe
name: Ahearn, Thomas U.
name: Andrulis, Irene L.
name: Anton-Culver, Hoda
name: Antonenkova, Natalia N.
name: Arndt, Volker
name: Aronson, Kristan J.
name: Augustinsson, Annelie
name: Baten, Adinda
name: Beane Freeman, Laura E.
name: Becher, Heiko
name: Beckmann, Matthias W.
name: Behrens, Sabine
name: Benitez, Javier
name: Bermisheva, Marina
name: Bogdanova, Natalia V.
name: Bojesen, Stig E.
name: Brauch, Hiltrud
name: Brenner, Hermann
name: Brucker, Sara Y.
name: Burwinkel, Barbara
name: Campa, Daniele
name: Canzian, Federico
name: Castelao, Jose E.
name: Chanock, Stephen J.
name: Chenevix-Trench, Georgia
name: Clarke, Christine L.
name: Conroy, Don M.
name: Couch, Fergus J.
name: Cox, Angela
name: Cross, Simon S.
name: Czene, Kamila
name: Daly, Mary B.
name: Devilee, Peter
name: Dörk, Thilo
name: Dos-Santos-Silva, Isabel
name: Dwek, Miriam
name: Eccles, Diana M.
name: Eliassen, A. Heather
name: Engel, Christoph
name: Eriksson, Mikael
name: Evans, D. Gareth
name: Fasching, Peter A.
name: Flyger, Henrik
name: Fritschi, Lin
name: García-Closas, Montserrat
name: García-Sáenz, José A.
name: Gaudet, Mia M.
name: Giles, Graham G.
name: Glendon, Gord
name: Goldberg, Mark S.
name: Goldgar, David E.
name: González-Neira, Anna
name: Grip, Mervi
name: Guénel, Pascal
name: Hahnen, Eric
name: Haiman, Christopher A.
name: Håkansson, Niclas
name: Hall, Per
name: Hamann, Ute
name: Han, Sileny
name: Harkness, Elaine F.
name: Hart, Steven N.
name: He, Wei
name: Heemskerk-Gerritsen, Bernadette A. M.
name: Hopper, John L.
name: Hunter, David J.
name: Jager, Agnes
name: Jakubowska, Anna
name: John, Esther M.
name: Jung, Audrey
name: Kaaks, Rudolf
name: Kapoor, Pooja Middha
name: Keeman, Renske
name: Khusnutdinova, Elza
name: Kitahara, Cari M.
name: Koppert, Linetta B.
name: Koutros, Stella
name: Kristensen, Vessela N.
name: Kurian, Allison W.
name: Lacey, James
name: Lambrechts, Diether
name: Le Marchand, Loic
name: Lo, Wing-Yee
name: Lubiński, Jan
name: Mannermaa, Arto
name: Manoochehri, Mehdi
name: Margolin, Sara
name: Martinez, Maria Elena
name: Mavroudis, Dimitrios
name: Meindl, Alfons
name: Menon, Usha
name: Milne, Roger L.
name: Muranen, Taru A.
name: Nevanlinna, Heli
name: Newman, William G.
name: Nordestgaard, Børge G.
name: Offit, Kenneth
name: Olshan, Andrew F.
name: Olsson, Håkan
name: Park-Simon, Tjoung-Won
name: Peterlongo, Paolo
name: Peto, Julian
name: Plaseska-Karanfilska, Dijana
name: Presneau, Nadege
name: Radice, Paolo
name: Rennert, Gad
name: Rennert, Hedy S.
name: Romero, Atocha
name: Saloustros, Emmanouil
name: Sawyer, Elinor J.
name: Schmidt, Marjanka K.
name: Schmutzler, Rita K.
name: Schoemaker, Minouk J.
name: Schwentner, Lukas
name: Scott, Christopher
name: Shah, Mitul
name: Shu, Xiao-Ou
name: Simard, Jacques
name: Smeets, Ann
name: Southey, Melissa C.
name: Spinelli, John J.
name: Stevens, Victoria
name: Swerdlow, Anthony J.
name: Tamimi, Rulla M.
name: Tapper, William J.
name: Taylor, Jack A.
name: Terry, Mary Beth
name: Tomlinson, Ian
name: Troester, Melissa A.
name: Truong, Thérèse
name: Vachon, Celine M.
name: Van Veen, Elke M.
name: Vijai, Joseph
name: Wang, Sophia
name: Wendt, Camilla
name: Winqvist, Robert
name: Wolk, Alicja
name: Ziogas, Argyrios
name: Dunning, Alison M.
name: Pharoah, Paul D. P.
name: Easton, Douglas F.
name: Zheng, Wei
name: Kraft, Peter
name: Chang-Claude, Jenny
name: Børresen-Dale, Anne-Lise
name: Grenaker Alnæs, Grethe I.
name: Sahlberg, Kristine K.
name: Ottestad, Lars
name: Kåresen, Rolf
name: Schlichting, Ellen
name: Holmen, Marit Muri
name: Sauer, Toril
name: Haakensen, Vilde
name: Engebråten, Olav
name: Naume, Bjørn
name: Fosså, Alexander
name: Kiserud, Cecile E.
name: Reinertsen, Kristin V.
name: Helland, Åslaug
name: Riis, Margit
name: Geisler, Jürgen
name: Clarke, Christine
name: Marsh, Deborah
name: Scott, Rodney
name: Baxter, Robert
name: Yip, Desmond
name: Carpenter, Jane
name: Davis, Alison
name: Pathmanathan, Nirmala
name: Simpson, Peter
name: Graham, Dinny
name: Sachchithananthan, Mythily
name: Amor, David
name: Andrews, Lesley
name: Antill, Yoland
name: Balleine, Rosemary
name: Beesley, Jonathan
name: Bennett, Ian
name: Bogwitz, Michael
name: Botes, Leon
name: Brennan, Meagan
name: Brown, Melissa
name: Buckley, Michael
name: Burke, Jo
name: Butow, Phyllis
name: Caldon, Liz
name: Campbell, Ian
name: Chauhan, Deepa
name: Chauhan, Manisha
name: Christian, Alice
name: Cohen, Paul
name: Colley, Alison
name: Crook, Ashley
name: Cui, James
name: Cummings, Margaret
name: Dawson, Sarah-Jane
name: DeFazio, Anna
name: Delatycki, Martin
name: Dickson, Rebecca
name: Dixon, Joanne
name: Edkins, Ted
name: Edwards, Stacey
name: Farshid, Gelareh
name: Fellows, Andrew
name: Fenton, Georgina
name: Field, Michael
name: Flanagan, James
name: Fong, Peter
name: Forrest, Laura
name: Fox, Stephen
name: French, Juliet
name: Friedlander, Michael
name: Gaff, Clara
name: Gattas, Mike
name: George, Peter
name: Greening, Sian
name: Harris, Marion
name: Hart, Stewart
name: Hayward, Nick
name: Hopper, John
name: Hoskins, Cass
name: Hunt, Clare
name: James, Paul
name: Jenkins, Mark
name: Kidd, Alexa
name: Kirk, Judy
name: Koehler, Jessica
name: Kollias, James
name: Lakhani, Sunil
name: Lawrence, Mitchell
name: Lindeman, Geoff
name: Lipton, Lara
name: Lobb, Liz
name: Mann, Graham
name: McLachlan, Sue Anne
name: Meiser, Bettina
name: Milne, Roger
name: Nightingale, Sophie
name: O’Connell, Shona
name: O’Sullivan, Sarah
name: Ortega, David Gallego
name: Pachter, Nick
name: Patterson, Briony
name: Pearn, Amy
name: Phillips, Kelly
name: Pieper, Ellen
name: Rickard, Edwina
name: Robinson, Bridget
name: Saleh, Mona
name: Salisbury, Elizabeth
name: Saunders, Christobel
name: Saunus, Jodi
name: Scott, Clare
name: Sexton, Adrienne
name: Shelling, Andrew
name: Southey, Melissa
name: Spurdle, Amanda
name: Taylor, Jessica
name: Taylor, Renea
name: Thorne, Heather
name: Trainer, Alison
name: Tucker, Kathy
name: Visvader, Jane
name: Walker, Logan
name: Williams, Rachael
name: Winship, Ingrid
name: Young, Mary Ann
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/699/67/1347
/692/499
article

description: Abstract: Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 × 10–2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.