An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
Creators: name: Park, Bo-Yong
name: Bethlehem, Richard AI
name: Paquola, Casey
name: Larivière, Sara
name: Rodríguez-Cruces, Raul
name: Vos De Wael, Reinder
name: Neuroscience In Psychiatry Network (NSPN) Consortium
name: Bullmore, Edward T
name: Bernhardt, Boris C
name: Bullmore, Edward
name: Dolan, Raymond
name: Goodyer, Ian
name: Fonagy, Peter
name: Jones, Peter
name: Moutoussis, Michael
name: Hauser, Tobias
name: Neufeld, Sharon
name: Romero-Garcia, Rafael
name: St Clair, Michelle
name: Vértes, Petra
name: Whitaker, Kirstie
name: Inkster, Becky
name: Prabhu, Gita
name: Ooi, Cinly
name: Toseeb, Umar
name: Widmer, Barry
name: Bhatti, Junaid
name: Villis, Laura
name: Alrumaithi, Ayesha
name: Birt, Sarah
name: Bowler, Aislinn
name: Cleridou, Kalia
name: Dadabhoy, Hina
name: Davies, Emma
name: Firkins, Ashlyn
name: Granville, Sian
name: Harding, Elizabeth
name: Hopkins, Alexandra
name: Isaacs, Daniel
name: King, Janchai
name: Kokorikou, Danae
name: Maurice, Christina
name: McIntosh, Cleo
name: Memarzia, Jessica
name: Mills, Harriet
name: O’Donnell, Ciara
name: Pantaleone, Sara
name: Scott, Jenny
name: Kiddle, Beatrice
name: Polek, Ela
name: Fearon, Pasco
name: Suckling, John
name: Van Harmelen, Anne-Laura
name: Kievit, Rogier
name: Chamberlain, Sam
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Neuroscience
connectome
neurodevelopment
adolescence
longitudinal
neuroimaging
multi-scale
Human

description: Funder: Canada Research Chairs; FundRef: http://dx.doi.org/10.13039/501100001804
description: Funder: Fonds de la Recherche du Quebec – Santé
description: Funder: Autism Research Trust
description: Funder: Canadian Institutes of Health Research; FundRef: http://dx.doi.org/10.13039/501100000024
description: Funder: BrainCanada
description: Funder: MNI-Cambridge collaborative award
description: Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional connectomes into compact manifold spaces, we identified a marked expansion of structural connectomes, with strongest effects in transmodal regions during adolescence. Findings reflected increased within-module connectivity together with increased segregation, indicating increasing differentiation of higher-order association networks from the rest of the brain. Projection of subcortico-cortical connectivity patterns into these manifolds showed parallel alterations in pathways centered on the caudate and thalamus. Connectome findings were contextualized via spatial transcriptome association analysis, highlighting genes enriched in cortex, thalamus, and striatum. Statistical learning of cortical and subcortical manifold features at baseline and their maturational change predicted measures of intelligence at follow-up. Our findings demonstrate that connectome manifold learning can bridge the conceptual and empirical gaps between macroscale network reconfigurations, microscale processes, and cognitive outcomes in adolescent development.