cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nicotine replacement in school-based cessation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Currently, their exists little research on how to get teenagers to stop using tobacco. The research that does exist does not include looking at the usefulness of nicotine gum as an aid to quitting. This study will provide that evidence. Coordinated through the Humboldt County Office of Education, the study will offer a quit program to all high school students and staff in Humboldt county in their schools. We hope to involve approximately 300 students in the program. Half of the students will be offered nicotine gum, and half will be offered an herbal gum, both of which are sold in stores as an aid to stop smoking. They will use the gum for 6 weeks, in lesser and lesser amounts. We will determine how many in each group have quit using tobacco 8 weeks and 6 months after they start using the gum.

 School teachers and school nurses will lead classes on how to deal with the gum and quitting. Through their experience working with the study, they will be able to continue the effective parts of the program after the study is over. They may also be encouraged to conduct more studies on their own on ways to get students to quit using the results and experiences they gain in this study.
Cerodontha (Dizygomyza) morosa
Creators: name: Eiseman, Charles S.
name: Lonsdale, Owen
name: Linden, John Van Der
name: Feldman, Tracy S.
name: Palmer, Michael W.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Cerodontha
Cerodontha morosa

description: Cerodontha (Dizygomyza) morosa (Meigen)
Material examined. OKLAHOMA: Payne Co., Mehan, 36.013839°, -96.998103°, 20.xii.2017, em. 12.ii.2018, M.W. Palmer, ex Carex amphibola, # CSE4377, CNC1135648 (1♀)
Hosts. Cyperaceae: [Carex * amphibola Steud., C. festucacea Willd.], C. gracillima Schwein., C. hitchcockiana Dewey, C. leptonervia (Fernald) Fernald (Eiseman & Lonsdale 2018).
Leaf mine. A long, whitish corridor, changing direction a few times, with frass in a single blackish lump toward the leaf apex.
Puparium. Yellowish or reddish to blackish-brown; formed within the mine, glued to the floor toward the base of the leaf.
Phenology and voltinism. In Massachusetts, Cerodontha morosa has been reared in late June and early July from leaf mines collected in June. In Oklahoma, tentatively identified females have been reared from overwintering pupae, and from mines collected in early and late May with adults emerging in early May and early June (Eiseman & Lonsdale 2018).
Distribution. USA: CA, MA, MO (Spencer 1981), [OK]; records from IL, IN, MD, MI (Priest et al. 2020), and SD require verification; Europe (Eiseman & Lonsdale 2018). The Montana record given by Spencer & Steyskal (1986) and repeated by Eiseman & Lonsdale (2018) was evidently an erroneous substitution for the Missouri record given by Spencer (1981).
Comments. This is the first record of an agromyzid from Carex amphibola.
description: Published as part of Eiseman, Charles S., Lonsdale, Owen, Linden, John Van Der, Feldman, Tracy S. & Palmer, Michael W., 2021, Thirteen new species of Agromyzidae (Diptera) from the United States, with new host and distribution records for 32 additional species, pp. 1-68 in Zootaxa 4931 (1) on page 22, DOI: 10.11646/zootaxa.4931.1.1, http://zenodo.org/record/4545337
Virtual world internet chat room for teen smoking cessation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking among children and adolescents has tremendous public health importance. Onset and development of smoking occurs primarily in adolescence, and because tobacco is highly addictive, regular use in adolescence develops into nicotine dependency. Smoking among adolescents is likely to continue into the adult years, increasing the risk of numerous long-term negative health consequences. Yet, even after three decades of efforts to prevent smoking among children, large numbers of young people continue to smoke. Further, although a large percent of adolescent smokers express an interest in quitting, few are successful.

 Unfortunately, adolescent smokers are difficult to recruit and retain in smoking cessation interventions, and even more discouraging, cognitive-behaviorally oriented cessation interventions that have been effective with adults, when tried with adolescents in school clinics and classrooms, have not shown much promise. Many believe that advances in health promotion among young people, including motivating interest in smoking cessation, will focus on innovative and appropriate use of emerging technologies such as computerized communication.

 Last year, a virtual reality chat room approach was pilot tested and evaluated in terms of feasibility (e.g., use and acceptability) and immediate effectiveness (e.g., changes in self-efficacy, intentions, and self-reported quit rates) with high-risk teen smokers recruited from six alternative high schools. A smoking cessation counselor trained in motivational interviewing techniques interacted with teen smokers in a real-time on-line virtual reality world. Results were very promising.

 In preparation for a proposal to test the chat room approach in a rigorous experimental design, over the next 18 months we are conducting efforts in four areas: (a) establishing strong connections with individual schools that would participate in further study, (b) developing an educational website-based intervention that would be an appropriate comparison with the virtual chat room cessation intervention, (c) refining the virtual world chat room intervention, and (d) refining the evaluation measures.

 The virtual world chat room approach for teen smoking cessation has both public health potential and practical appeal. Virtual reality chat rooms can provide a technology appealing to adolescent boys and girls that is both convenient and “naturalistic” in that it involves real-time communication. The computer-based cessation program can overcome many of the traditional barriers of school-based cessation programs, and offer a potentially effective intervention for a population that may be especially resistant to quitting smoking and for whom other strategies have not proven very effective or practical.
Progymnodon Dames 1883
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Tetraodontiformes
Progymnodon

description: Genus Progymnodon Dames, 1883
Type species
Progymnodon hilgendorfi Dames, 1883, middle Eocene, Egypt.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 182, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
P-42 Injectable medication at the end of life: a common task for generalist community clinicians
Creators: name: Marvin, Rosamund
name: Grove, Sarah
name: Spathis, Anna
name: Barclay, Stephen
Publisher: name: British Medical Journal Publishing Group
Year: 2017
Subjects: 4203 Health Services and Systems
4205 Nursing
42 Health Sciences
Health Services
Clinical Research
Behavioral and Social Science
7.2 End of life care
6.1 Pharmaceuticals

description: Background. Injectable medications are commonly prescribed for patients at home approaching the end of their lives, either in response to, or in anticipation of, symptoms. Aims. With regard to injectable drugs for patients approaching the end of their lives in the community, to investigate: a. What drugs are prescribed? b. What drugs are administered? c. Who administers the drugs? Design and setting. Service evaluation of the Bedfordshire PEPS (Partnership for Excellence in Palliative Support) Co-ordination Centre, a 24 hour support service for palliative care patients. Medication data were extracted from patient records on SystmOne, the local community computerised healthcare record, concerning patients registered with PEPS who had died within a one year period. Results. Of 1087 patients registered with PEPS who died within a 1 year period, 392 (36%) were prescribed injectable medications, most commonly midazolam (88%), diamorphine (85%), cyclizine (72%) and glycopyrronium (67%). 328 (84%) out of the 392 spent part or all of their last week of life at home. Of these, 232 (71%) had injectable drugs administered during that time: diamorphine (72%), midazolam (66%), glycopyrronium (41%) and cyclizine (31%). Most (81%) were given more than one drug and half (52%)were given drugs both by continuous subcutaneous infusion and as stat doses. The drugs were most often given by generalist community nurses or nursing home staff (91%). There was little difference between drug prescription and administration in malignant or non-malignant disease. Conclusions. When prescribed, injectable medication is frequently used in the last week of life, especially diamorphine, midazolam, cyclizine and glycopyrronium. Administration is usually by staff who are not specialist in palliative care, highlighting the need for support and education for community healthcare professionals.
Speciation analysis of inorganic arsenic in water samples using thiol-ligand and cotton fibres followed by ICP-OES determination
Creators: name: Triteeyaprasert, Kavee
name: Chansuvarn, Woravith
name: Praphairaksit, Narong
name: Imyim, Apichat
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: This research aimed to develop a method for the speciation analysis of arsenic species, including As(III) and As(V) in environmental samples. Cotton fibres and thiol-ligands, including ammonium pyrrolidine dithiocarbamate (APDC), L-cysteine, and diethyldithiocarbamic acid (DDTC), were used as a simple solid phase extraction (SPE) followed by arsenic determination using inductively coupled plasma optical emission spectrometry (ICP-OES). The separation parameters were thoroughly investigated, including pH, thiol-ligand concentration, cotton fibre amount, type of eluents, and flow rate. It was found that As(III) could be efficiently separated from As(V) by using a column containing 0.5 g cotton fibres and 0.1% APDC under pH 2. As(III) was then eluted using 5 mL of mixed solvents of 4 M HNO3, 4 M HCl, and 0.5 M H2O2 (1:1:1 v/v). The method was then used to perform a speciation analysis of arsenic in model solutions with As(III) and As(V) concentrations ranging from 10–1000 μg/L. The results showed good recoveries of both arsenic species at 80–120% with a satisfactory percentage relative standard deviation (%RSD). The developed method was subsequently applied for arsenic speciation analysis in the environmental samples, including natural and wastewater samples.
Decolonizing Christianity
Creators: name: Fontaine, Darcie S.
Publisher: name: No Publisher Supplied
Year: 2011

description: This dissertation, “Grassroots Ecumenism: Christianity and Decolonization in France and Algeria, 1940-1965” is the first major study of how French Protestant and Catholic engagement in the Algerian War of Independence (1954-1962) reshaped Christianity in the modern world and influenced global religious movements like Ecumenical Movement and Vatican II. The moral questions that surfaced during the Algerian War, including the French military’s use of torture, the repression of civilian populations, and debates about the legitimacy of the Algerian nationalist positions forced Christians across the world to rethink the role of Christianity in imperialism and its future in a postcolonial world. This dissertation examines the shifting dynamics of Christianity’s role in the French empire, from the role that Christianity played in supporting the moral foundations for French colonialism in Algeria, to the ways in which Social Christianity, which emerged in France in the 1930s and 40s, undermined these same moral arguments, including the belief that French colonialism was both benevolent and the only means through which Christian interests could be protected in Algeria. Using private and governmental archives from France, Switzerland, Algeria, and Tunisia, this dissertation argues that the Algerian War, the most brutal and violent conflict over decolonization in the French empire, was a testing ground for the decolonization of Christianity itself. It traces a group of French Christians who used Christian theology and morality to argue for social justice for colonized peoples, and even political independence. Although many of these Christians were arrested and tortured for their support of the Algerian population, they worked toward a decolonization of the church in Algeria by initiating a dialogue with Algerian Muslims and working with them to solve some of the grave social problems that were at the root of Algerian discontent. This project thus traces the transformation of Christianity from its position as the moral foundation of European imperialism to its role as a radical voice of political and social change in the era of decolonization, and the complex tensions that resulted as Christians attempted to renegotiate their place in the emerging Third World.
Dysoxylum flavescens Hiern
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum flavescens

description: 6. Dysoxylum flavescens Hiern in Hooker, Fl. Brit. India 1: 549. 1875 – Holotype: Malaysia, Melaka, Maingay 3341 [
= Kew Distr. No. 321] (K [over two sheets] barcodes K001368874! & K001368875!).
Distribution. – Sumatra to Borneo.
Note. – See also Mabberley (2013a: 211).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Transcriptional regulation in normal and neoplastic lung
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The primary cause of lung cancer is smoking. Presumably, tobacco smoking changes the expression or function of several genes that regulate growth of epithelial cells in the respiratory tract. While we know the identity of many genes involved in this process, it is likely that several genes important for lung carcinogenesis remain to be discovered. Lessons from the study of organ development suggest that many genes important for normal development, even in simple organisms such as the fruit fly, often play roles in cancer formation. Consequently, one approach to identify novel genes significant for the formation of lung cancer is to search and test the function of genes that have been shown to play crucial roles in normal development.

 We are studying the role of a protein called LMO-4 that is involved in gene regulation. Because LMO-4 is highly related to oncogenes causing leukemia, we have proposed that it plays a role in the regulation of lung epithelial cells in normal lung and in lung cancer. Recently, we have isolated a new gene that encodes a protein that associates with LMO-4. This gene, NTF-1, corresponds to a gene that is required for the formation of the cuticle and trachea in fruit flies. We propose to test the function of this new gene in mammalian lung formation and in lung cancer.

 We already know that, besides low level expression of NTF-1 in the brain, this gene is selectively expressed in epithelial cells, including those of internal epithelia such as in the developing lung. Based on the importance of NTF-1 in formation of epithelial tissues in fruit flies, we propose that the mammalian NTF-1 gene plays similar critical functions in epithelial cells of the lung. Further, we suggest that subversion of the function or expression of NTF-1 may play a role in lung cancer.

 To test this idea, we plan to carefully study where NTF-1 is expressed in the lung both during normal lung development and in lung cancers. To test the function of the mammalian NTF-1 gene more definitively, we propose to disrupt the gene in animal models and examine changes in the lungs and other epithelial tissues.

 These experiments may lead to insights into how normal and cancerous lung tissue forms. Our hope is to identify one or more of the molecules and pathways that contribute to lung cancer formation in response to smoking. In the long-term, these studies may also provide ideas for new treatments of lung cancer.
Mitotic spindle checkpoint & chromosomal instability
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer is a diseased state which develops from abnormalities in the proteins that control cell birth and cell death. However, the exact mechanisms through which these abnormalities are generated are still debatable. One of the mechanisms that is thought to drive the development of cancer is genetic instability. In a majority of colon cancers, and most other tumor types, genetic instability is manifest at the chromosomal level and is characterized by an abnormal number of chromosomes in the cells. Studies have shown that the majority of cancers have gained or lost chromosomes. The average cancer of the colon, breast, pancreas or prostate may lose as many as 25% of its chromosomes. The sources of these errors probably drive more and more abnormal cell growth. Normally cells try to ensure that each daughter cell receives one copy of each chromosome. The way this happens is through a quality control mechanism called the mitotic spindle checkpoint. This checkpoint allows every chromosome to send a stop signal, arresting cell growth till all the chromosomes are appropriately distributed. Defects in different components of the mitotic spindle checkpoint have consistently been observed in cancer cells. These cancers are characterized by chromosomal instability. For example, frequent impairment of mitotic spindle checkpoint has been observed in human lung cancer cell lines, and in a small fraction of colorectal cancer cells, abnormal chromosomal numbers have been proposed to be associated with defects in two of the human mitotic spindle checkpoint genes, namely BUB1 and BUBR1. However, the exact function of BUB1 and BUBR1 are not understood, although it is thought that both BUB1 and BUBR1 are part of a signalling cascade that relays a signal to inhibit further progression of cell cycle if defects in chromosome distribution are detected. The objective of the proposed study is to investigate this aspect in detail and thus determine whether BUB1 and BUBR1 may function as tumor suppressors. To acheive that objective, I aim to selectively delete these genes in mice in order to examine whether these genes are essential for normal development and whether their disruption leads to genetic instability, thereby promoting the progression to tumorigenesis. Further, the proposed study will also serve as a starting point for the experiments designed to test the prediction that mutations (genetic defects) in mitotic checkpoint genes will frequently be found in human tumors arising from mutations in other cancer related genes. These studies will have implications for the pathogenesis of cancer and may in the long run yield entirely new approaches to treating common forms of cancer.
Novel neurochip design implementing ALOPEX for use in an automated deep brain stimulation system for Parkinson’s patients
Creators: name: Elkholy, Emir
Publisher: name: No Publisher Supplied
Year: 2011

description: In order to counteract the debilitating effects of Parkinson’s disease, Deep Brain Stimulation (DBS) is used. However, due to the invasive nature of the procedure associated with DBS, there is a need for a system that can autonomously and reliablyadjust itself based on the progression of the disease. The purpose of the neurochip in this system will be to autonomously counteract the abnormal brain behavior that causes tremors in Parkinson’s patients by sensing and stimulating portions of the brain over anextended period of time. Using the optimization technique ALOPEX developed in the Computational Intelligence Laboratory at Rutgers Biomedical Engineering, the developed hardware is able to reduce the unpleasant tremor and offer the subjects amuch-improved quality of life. The promise of such research can lead to a device that would reduce the need for visits to doctors for parameter adjustment purposes. The approach of the research was to first enter recorded Parkinsonian brain activity in software, and develop the complete algorithm used to counteract the tremor. From this phase, the software is implemented using microcontrollers where it is tested for robustness in the laboratory. The final stage of research lays the groundwork for VLSI design of the device that can be fabricated. In theory, it has been shown that ALOPEX can successfully adapt the stimulation parameters in DBS in order to maintain the optimal condition for the patient. Clinical testing on animals/humans will need to be done in orderto verify these results.
Nutritional and hormonal modulation of insulin-like growth factor-1 with respect to growth in sexually dimorphic lizards
Creators: name: Duncan, Christine
Publisher: name: No Publisher Supplied
Year: 2011

description: In many species of animals, adults of one sex grow faster or for a longer period of time to become larger than the other. Sex differences in growth rate can often be attributed to differences in androgenic versus estrogenic hormonal effects on the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. In this paradigm, testosterone (T) stimulates hepatic IGF-1 message, resulting in an increase in plasma IGF-1, while estrogenic hormones have the opposite effect. However, this generality is inherently biased because studies have focused almost entirely on male-larger species. Previous work in lizards has demonstrated that T inhibits growth in female-larger species, while stimulating growth in male-larger species. Thus, the effect of T on IGF-1 may not be universal but may depend on a species’ pattern of sexual size dimorphism. Since IGF-1 had not previously been characterized in lizards, my research required the development of novel assay techniques. To this end, a partial sequence of IGF-1 was cloned. Comparison of the deduced amino acid sequences of IGF-1 confirmed high sequence identity (72 – 80%) between lizards and the corresponding region in human. These sequences supported the development of assays to characterize the response of IGF-1 to variation in food intake. In S. undulatus, zero ration decreased hepatic IGF-1 message and plasma IGF-1, while re-feeding restored levels to that of full ration. In yearling S. jarrovii, 1/3 ration had no effect on hepatic IGF-1 message compared to full ration. Altogether, results from nutritional manipulation in Sceloporus lizards are consistent with previous work but suggest that food restriction short of starvation may have little effect on IGF-1. Following the validation of assays, we investigated the effects of T on IGF-1 in a female-larger species, S. undulatus. Contrary to published studies on male-larger species, T decreased hepatic IGF-1 message in adult males and juvenile males and females. However, T did not affect plasma IGF-1. Our results challenge the widespread belief that males grow faster than females by increasing their production of IGF-1.
Dysoxylum gotadhora
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum gotadhora

description: 7. Dysoxylum gotadhora (Buch.-Ham.) Mabb. in Wu & al., Fl. China 11: 127. 2008 ≡ Guarea gotadhora Buch. - Ham. in Mem. Wern. Nat. Hist. Soc. 6: 307. 1832
– Holotype: India, Assam, “Camrupa”, Buchanan-Hamilton 935 (E barcode E00301282!).
Distribution. – India, Bhutan and Nepal to China andThailand.
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Liriomyza arctii Spencer
Creators: name: Eiseman, Charles S.
name: Lonsdale, Owen
name: Linden, John Van Der
name: Feldman, Tracy S.
name: Palmer, Michael W.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Liriomyza
Liriomyza arctii

description: Liriomyza arctii Spencer
Material examined. MASSACHUSETTS: Hampshire Co., Northampton, 42.318438, -72.643259, 1.vi.2018, em. 19–21.vi.2018, C.S. Eiseman, ex Silphium perfoliatum, # CSE4637, CNC1144085–1144088 (3♁ 1♀).
Hosts. Asteraceae: Arctium lappa L., A. minus (Hill) Bernh., Bidens cernua L., Heliopsis helianthoides (L.) Sweet, * Silphium perfoliatum L., Verbesina alternifolia (L.) Britton ex Kearney (Eiseman & Lonsdale 2018).
Leaf mine. Greenish, entirely linear; on Heliopsis and Verbesina, frass is diffuse throughout, whereas on the oth- er hosts, there are more or less distinct, black, alternating strips in the later portion (Eiseman & Lonsdale 2018).
Puparium. Yellow to brown (dark brown according to Spencer 1969), formed outside the mine.
Phenology and voltinism. This species is multivoltine in the northeastern USA. We have collected larvae in early June, mid-July, early August, and late September, with adults emerging in 12–23 days in all cases except the last, when the pupae overwintered (Eiseman & Lonsdale 2018).
Distribution. Distribution. USA: CT, MA, MN, NY, OH, WI; Canada: ON (Eiseman & Lonsdale 2018).
Comments. This is the second Liriomyza species to be reared from Silphium, after L. ivorcutleri Eiseman & Lonsdale, which is known from a single Iowa specimen (Eiseman & Lonsdale 2018).
description: Published as part of Eiseman, Charles S., Lonsdale, Owen, Linden, John Van Der, Feldman, Tracy S. & Palmer, Michael W., 2021, Thirteen new species of Agromyzidae (Diptera) from the United States, with new host and distribution records for 32 additional species, pp. 1-68 in Zootaxa 4931 (1) on pages 23-24, DOI: 10.11646/zootaxa.4931.1.1, http://zenodo.org/record/4545337
Albula Scopoli 1777
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Albuliformes
Albulidae
Albula

description: Genus Albula Scopoli, 1777
Type species
Esox vulpes Linneaus, 1758, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 186, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Alternative analyses of political representation in urban Congressional districts
Creators: name: Dunn, Marika-Eugenia
Publisher: name: No Publisher Supplied
Year: 2011

description: This dissertation critically examines the processes and outcomes of the representative constituencyrelationship within urban congressional districts in the United States. In each of the dissertation’s three essays, the project addresses the following claims: 1)studies of representation within a political jurisdiction may be more robustly addressed through analyses of a variety of tools that members use to foster relationships with their constituencies; 2) members who represent racial and ethnic minorities and other politically marginalized or vulnerable constituencies utilize a number of these tools of representation to develop and maintain relationships with their constituencies; and 3) the study of representation in the U.S. is intrinsically linked to conceptual and physical spatial elements that define the parameters of political behavior toward particular constituents or communities. The project incorporates data from a variety of sourcesincluding participant observation and interviews of congressional staff as well as congressional hearings, appropriations earmarks, and census data to substantiate both the overall claims as well as specific conclusions posed within each essay.
Siah-family proteins in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Defects in the control of cell division occur in essentially all cancers, including those that arise in the lung. The molecular events that underlie the aberrant growth of malignant cells are only partially understood. With each new insight into the mechanisms responsible for tumor growth, scientists are provided with additional molecular targets for potential therapeutic intervention. In this proposal, we seek to understand the mechanisms of an intracellular cell growth regulator, called Siah. We have determined that Siah inhibits cancer cell growth and that it can be induced by some stimuli that cause arrest of tumor cell division. To understand how Siah functions, we cloned genes encoding proteins that bind to Siah. By studying the interactions of Siah with these other proteins, we hope to gain novel insights into aberrant growth regulation in lung cancers and to devise strategies for new therapeutic approaches to cancer. Moreover, some of the proteins targeted by Siah are relevant to attempts to prevent cancres of the lung using vitamin-A-like drugs (retinoids), suggesting that information derived from our studies could suggest novel strategies for cancer prevention in persons who refused to abandon cigarette smoking. Our goals are to define some of the mechanisms which Siah-family proteins use to control the turnover of various target proteins involved in cell growth regulation, and to understand more about the regulation of Siah-family gene expression in lung cancers.
Fabrication and characterization of low crystalline curcumin loaded lipid  nanopartilcles
Creators: name: Du, Yuechao
Publisher: name: No Publisher Supplied
Year: 2011

description: Preventable chronic diseases such as cardiovascular disease, cancer account for nearly 70% of the death in the States annually. Research attributes these diseases to oxidation stress induced by free radicals. Recently, it is shown that risk of chronic diseases can be minimized by increasing intake of antioxidant. The increasing public health awareness has lead to intense need for functional food enriched with powerful antioxidants. Recent research reveals that polyphenolic compounds such as quecertin,curcumin possess great anti-oxidation and anti-cancer potential. However, enriching food with these antioxidants has been limited, because these compounds usually have poor solubility and chemically unstable. Solid lipid nanoparticles offer promising approach to deliver these hydrophobic compounds. However, it has been noted that solid lipid nanoparticles have limited loading capacity due to high crystallinity of lipid crystals. In addition, fast polymorphic transition of lipid leads to aggregation and burst release of encapsulated compound. To overcome these limitations, Nanostructured lipid carriers composed of solid lipids and liquid lipids are developed. Until recently, little research has been done on SLN and NLC for food application. In this research, food grade materials are used to fabricate SLN and NLC via ultrasonication. Curcumin, a polyphenolic antioxidant is chosen to be model compound to be encapsulated. The surface morphology of SLN and NLC are studied by dynamic light scattering and transmission electron microscope. Structure and molecular interaction of lipid nanoparticles are explored by Raman spectroscope. Differential scanning calorimetry and X-ray diffraction technique are applied to provide more insight information about crystallinity and the effect of different components on polymorphic transition of lipid nanoparticles. Research results show curcumin is encapsulated in spherical lipid nanoparticles. The encapsulation greatly improves the chemical stability of curcumin under extreme alkaline condition. Curcumin loaded SLN shows structure of curcumin enriched core with lipid shell. The average size of SLN is between 200-500nm. However, aggregation takes place shortly during storage. NLC has lower crystallinity than SLN. Lipid polymorphic transition in NLC is retarded by the addition of methyl stearate, oleic acid. In addition, smaller particles are formed in methyl stearate NLC and oleic acid NLC.
Dysoxylum grande Hiern
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum grande

description: 8. Dysoxylum grande Hiern in Hooker, Fl. Brit. India 1: 547. 1875
– Holotype: India, Assam, Sylhet, Bruce EIC 4883 (P barcode P06666598!).
Distribution. – India (Assam) and S China to Borneo and probably Philippines.
Note. – See also Mabberley (2013a: 212).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Pythonichthys Poey 1868
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Anguilliformes
Heterenchelyidae
Pythonichthys

description: Genus Pythonichthys Poey, 1868
Type species
Pythonichthys sanguineus Poey, 1868, Recent, Cuba.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 187, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
ETNOPSIXOLOGIK TADQIQOTLARDA ISHLATILADIGAN METODLAR VA ULARGA QO'YILADIGAN TALABLAR
Creators: name: Shermatova, Qunduz
name: Rajaboyeva, Marjona
name: Mambetiyarova, Venera
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada etnopsixologiya va uning tadqiqotlarida oʻtkaziladigan shkalali oʻlchov,kuzatish va soʻrov  hamda proyektiv metodlari haqida soʻz yuritiladi.
Development of a disposable hollow fibre-solid phase microextraction device using chitosan functionalised MWCNTs and a polyoxometalate for the simultaneous extraction of angiotensin II receptor blocker drugs
Creators: name: Mohseni, Aref Ansari
name: Ebrahimi, Mahmoud
name: Beyramabadi, Safarali
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Valsartan and Losartan are two angiotensin II receptor blocker drugs used to treat heart failure and high blood pressure. A straightforward and disposable hollow fibre-solid phase microextraction device was developed to extract these drugs from real water and urine samples. A green sorbent was synthesised by functionalised MWCNTs with chitosan through a chemical route method. Besides, a polyoxometalate (Ni-CoWO4 nanoparticles) was prepared as a modifier using the hydrothermal procedure. Using the sol-gel strategy, the sorbent and modifier were reinforced in the hollow fibre pores and lumen. The approach leads to an increase in the sorbent coating stability on/in hollow fibre. The influential factors were optimised with an experimental design, indicating that pH, extraction time, and desorption time significantly affect the Valsartan and Losartan extraction. The linearity of the method to determine Valsartan and Losartan was 3.4–1850 and 3.1–1800 ng mL−1, with R squared of 0.9929 and 0.9947, respectively. The detection and quantification limits were lower than 0.9 ng mL−1 and 3.4 ng mL−1, respectively. The pre-concentration factors for determining Valsartan and Losartan with a concentration of 20 ng mL−1 were 654.2 and 546.3, respectively. The intra-day and inter-day RSDs were lower than 3.11% and 3.87% for measuring Valsartan and Losartan. The recoveries and RSDs for analysing spiked eal water and urine samples were between 91.8–97.8% and 3.16–4.10%, respectively.
Thiol-aldehyde adducts and tobacco smoke toxicity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is well appreciated that cigarette smoking is associated with cancer, cardiovascular and pulmonary diseases such as chronic bronchitis and emphysema. Although the relationships between the variety of diseases and smoking are well established, the biochemical mechanisms underlying the effects of smoking are not well understood. It is important to understand these biochemical mechanisms to treat the diseases associated with smoking. There are many harmful components in cigarette smoke (CS) that can damage biomolecules such as lipids, proteins and nucleic acid present in cells, eventually leading to cell death. Antioxidants such as vitamin C, glutathione, and uric acid can protect us from damage induced by cigarette smoke. Of these antioxidants, glutathione is present in the largest amounts within cells and is rapidly depleted in the presence of tobacco smoke. The reason for the rapid depletion of glutathione is that it contains a thiol group (-SH group) in it, which is very susceptible to damage by smoke. Also, proteins contain -SH groups, which can be damaged easily leading to loss in protein function. Administration of thiol group-containing drugs (such as N-acetyl cysteine) may prevent the loss of protein thiol groups noted in smokers.

 Until now the products formed between glutathione and CS have not been identified. However, the preliminary results presented in this proposal show that in test tube experiments, a majority of glutathione forms an irreversible adduct with acrolein, a very reactive component present in CS. This proposal intends to measure the formation of glutathione-acrolein adducts in cells lining the surfaces of the lung (pulmonary epithelial cells). The identification of these adducts will help to emphasize that the reactions are also relevant physiologically. Identification of these adducts will help us in the future to design studies to determine the formation and clearance of these adducts in smokers. These studies are essential since glutathione-acrolein adducts are themselves observed to be toxic in animals leading to kidney failure. The proposal also intends to identify the effect of CS on –SH containing proteins involved in cell signaling pathways. For example, the enzyme protein tyrosine phosphatase 1B (PTP 1B) regulates the activity of important receptors such as the epidermal growth factor receptor and the insulin receptor. This phosphatase also regulates the activity of an oncogene kinase, which suggests it may play a role in tumor supression. Studying the effect of the components of CS on the activity of this critical enzyme will help determine how smoking can interfere with important signaling pathways involved in growth and proliferation of cells.
Cell-cell interact reg distrib of nic receptrs on neurons
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco consumption is the leading cause of premature deaths in the United States. Nicotine has been identified as the principal addictive component in tobacco smoke causing this pathological behavior. In all known cases nicotine exerts its actions in the body by acting on a family of specific nicotinic receptors. These receptors are proteins on the surface of neuronal cells that bind nicotine and cause an electrical event to occur inside. These electrical events represent one of the basic signaling mechanisms used for information processing in the nervous system. One of the most abundant nicotinic receptors in our nervous system is the one containing the a7-receptor, which has the unusual feature of allowing large amounts of calcium to enter cells. Calcium is a critically important element that regulates fundamental processes in the brain. Recent evidence from a number of sources indicate that a7-receptors are capable of many functions in the brain as a result, and that, when inappropriately activated or regulated, may contribute to diverse pathologies including schizophrenia, lung cancer, and degeneration of cells in the brain. How the a7-receptors achieve their effects, what their physiological significance is normally for brain function, and how they are influenced by prolonged exposure to nicotine are questions that remain largely unanswered.

 The fact that a7-receptors can display multiple functions depending on their location on the cell surface, directs attention to the mechanisms responsible for the delivery of receptors to specific sites. To address this issue, the experiments proposed here will test the effect that intercellular interactions have on the distribution and function of nicotinic receptors expressed on the cell surface.

 Because a7-receptors – possibly one of the most important nicotinic acetylcholine receptors in the nervous system – can quickly elevate intracellular calcium levels and because these receptors appear early and in a variety of places, they are positioned to influence many events during development. The expected results arising from this project will provide new information about the signaling mechanisms of a7-receptors and may suggest development events at risk by prolonged exposure to nicotine, e.g. during pregnancy. The outcome will be a better understanding of the consequences of smoking, new insights into mechanisms that may contribute to the nicotinic response, and may suggest intervention strategies of biomedical relevance.
Dysoxylum latifolium Benth., Fl. Austral.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum latifolium

description: 9. Dysoxylum latifolium Benth., Fl. Austral. 1: 381. 1863
– Holotype: Australia, Queensland, Frankland Islands,MacGillivray, Voyage of Rattlesnake Bot. 300(K barcode K000657151!).
Distribution. – New Guinea and N Australia to Vanuatu.
Note. – See also Mabberley (2013b: 32).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Динамічний скринінг зовнішнього державного боргу
Creators: name: Разінькова, М. Ю.
Publisher: name: Zenodo
Year: 2024
Subjects: борг, зовнішній державний борг, динамічний скринінг, держава, DSGE-модель, фінансова стабільність, управління ризиками, стратегія.

description: Взаємодія динамічних факторів, таких як мінливі макроекономічні умови, політичні аспекти та непередбачувані потрясіння, вимагає вдосконалених аналітичних інструментів для ефективної оцінки ризиків зовнішнього боргу. Враховуючи сучасні методологічні засади динамічного скринінгу державного зовнішнього боргу, можна стверджувати, що існує декілька основних напрямів його реалізації. Визначено, що найпростішим способом динамічного скринінгу державного зовнішнього боргу є аналіз його динаміки. Проаналізовано відмінності між поточними та минулими значеннями зовнішнього державного боргу. Визначено, що ключовим підходом, який найкраще відповідає вимогам складності та невизначеності, є модель динамічної стохастичної загальної рівноваги (DSGE). Встановлено, що застосування моделей динамічної стохастичної загальної рівноваги (DSGE) для аналізу зовнішнього державного боргу в умовах воєнного часу передбачає реалізацію поетапного алгоритму дій. Модель DSGE надає систему диференціальних рівнянь, що описують взаємодію різних параметрів та еволюцію ключових економічних змінних у часі. Наведено методологію розрахунку параметрів DSGE-моделі для динамічного скринінгу зовнішнього державного боргу України. Розроблена методика є важливим інструментом для всебічного розуміння економічної ситуації в Україні, особливо в умовах війни. Отриманий у процесі розрахунку індекс DSGE вказує на необхідність термінового вдосконалення стратегії управління ризиками. Проведений аналіз підкреслює важливість систематичного моніторингу економічних і фінансових показників для забезпечення стійкості державного боргу та фінансової стабільності в ситуаціях політичної та економічної нестабільності. З точки зору стратегій управління ризиками варто розробити та впроважувати ефективні стратегії управління ризиками, спрямовані на зменшення негативного впливу воєнних подій на державний борг і фінансову стабільність. З точки зору моніторингу та адаптації варто проводити систематичний моніторинг економічних і фінансових показників та розробити адаптивні заходи, що допоможуть керувати динамікою державного боргу під час воєнних потрясінь.