cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Osteomyelitis in Late-Stage Pressure Sore Patients: A Retrospective Analysis
Creators: name: Ruewe, Marc
name: Siegmund, Andreas
name: Rupp, Markus
name: Prantl, Lukas
name: Anker, Alexandra M.
name: Klein, Silvan M.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: pressure sore; pressure ulcer; reconstructive surgery; tissue repair; patient outcomes; humans; aged; retrospective analysis; osteomyelitis; c-reactive protein; blood count
subject: 610 Medizin

description: Background: Late-stage pressure sore (PS) patients are particularly susceptible to osteomyelitis
(OM), as bony prominences commonly constitute the focal point of the ulcer. There are
lack of data regarding the associated factors and the clinical relevance of this diagnosis in the context
of PS treatment. Methods: This retrospective analysis investigated the clinical characteristics, blood
markers indicative of infection in PS patients, and development of histologically evident OM. A total
of 125 patient were included from 2014 to 2019. The patient records were especially scanned for histological
diagnosis of OM. Results: OM was detected in 39% (37/96) of the samples taken during the
index procedure. OM prevalence increased to 56% (43/77) at the second and 70% (41/59) at the third
debridement. Therefore, the diagnosis of OM was acquired during treatment in 35 cases. Patients
diagnosed with initial OM presented significantly higher blood markers, indicative of infection upon
admission. Only patients with consistent OM (three positive biopsies) showed higher flap revision
rates. Conclusion: This study found no compelling evidence linking OM to worse clinical outcomes
in PS patients. In the absence of elevated inflammatory markers, reducing bone biopsy frequency
and adopting a less aggressive bone debridement approach may help prevent OM in PS patients.
Serum Phosphatidylcholine Species 32:0 as a Biomarker for Liver Cirrhosis Pre- and Post-Hepatitis C Virus Clearance
Creators: name: Weigand, Kilian
name: Peschel, Georg
name: Grimm, Jonathan
name: Höring, Marcus
name: Krautbauer, Sabrina
name: Liebisch, Gerhard
name: Müller, Martina
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: hepatitis C; direct-acting antivirals; liver cirrhosis; genotype; phosphatidylcholine
subject: 610 Medizin

description: Phosphatidylcholine (PC) is an essential lipid for liver health and lipoprotein metabolism,
but its circulating levels have rarely been studied in patients with cirrhosis. Chronic hepatitis C
virus (HCV) infection causes lipid abnormalities and is a major cause of cirrhosis. Effective HCV
elimination with direct-acting antivirals (DAAs) is associated with the normalization of serum lowdensity
lipoprotein cholesterol levels. Since PC is abundant in all lipoprotein particles, this study
analyzed the association between serum PC species levels and liver cirrhosis before and after HCV
eradication. Therefore, 27 PC species were measured by Fourier Transform Mass Spectrometry in
the serum of 178 patients with chronic HCV infection at baseline and in 176 of these patients at the
end of therapy. The PC species did not correlate with viral load, and the levels of 13 PC species were
reduced in patients infected with genotype 3a compared to those affected with genotype 1. Four PC
species were slightly elevated 12 weeks after DAA initiation, and genotype-related changes were
largely normalized. Patients with HCV and cirrhosis had higher serum levels of PC 30:0 and 32:0
before and at the end of therapy. PC species containing polyunsaturated fatty acids were mostly
decreased in cirrhosis. The levels of polyunsaturated, but not saturated, PC species were inversely
correlated with the model of the end-stage liver disease score. A receiver operating characteristic
curve analysis showed area under the curve values of 0.814 and 0.826 for PC 32:0 and 0.917 and 0.914
for % PC 32:0 (relative to the total PC levels) for the classification of cirrhosis at baseline and at the
end of therapy, respectively. In conclusion, the specific upregulation of PC 32:0 in cirrhosis before
and after therapy may be of diagnostic value in HCV-related cirrhosis.
Microakodontomys Hershkovitz 1993
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microakodontomys

description: Microakodontomys Hershkovitz 1993
Microakodontomys Hershkovitz 1993, Fieldiana Zool., n. s., 75: 2.
Type Species: Microakodontomys transitorius Hershkovitz 1993
Species and subspecies: 1 species:
Species Microakodontomys transitorius Hershkovitz 1993
Discussion: Oryzomyini. Provisionally left as Sigmodontinae incertae sedis by Hershkovitz (1993:2), who remarked that "Overall resemblance to Microryzomys and Oligoryzomys suggests differentiation from an oryzomyine stock in a scrub brush habitat transitional between forest and savanna." To us, the holotype displays features that clearly ally it with Oryzomyini sensu Voss and Carleton (1993). Founded on a single young specimen with damaged skull, the diagnostic traits of this new genus and species, which "could be mistaken for a well-differentiated species of Oligoryzomys " (Hershkovitz, 1993:4), should be verified with improved series from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients
Creators: name: Schmidtner, Niklas
name: Utrata, Alexander
name: Mester, Patricia
name: Schmid, Stephan
name: Müller, Martina
name: Pavel, Vlad
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: septic shock; SIRS; COVID-19; C-reactive protein; survival; BMP6
subject: 610 Medizin

description: Infectious diseases are associated with low iron levels and the induction of hepcidin, the primary protein regulating cellular iron export. Bone morphogenetic protein 6 (BMP6), a key regulator of hepcidin expression, has not yet been analyzed in the plasma of patients with systemic inflammatory response syndrome (SIRS) or sepsis. An analysis of 38 SIRS, 39 sepsis, and 78 septic shock patients revealed similar levels of BMP6 in sepsis and septic shock, which were lower compared to patients with SIRS and healthy controls. Plasma BMP6 levels did not correlate with procalcitonin and C-reactive protein levels in patients with SIRS or sepsis/septic shock. Neither bacterial nor SARS-CoV-2 infections affected plasma BMP6 levels. There was no difference in BMP6 levels between ventilated and non-ventilated patients, or between patients with and without dialysis. Vasopressor therapy did not alter BMP6 levels. Survivors had plasma BMP6 levels similar to non-survivors. Due to the high variability of plasma BMP6 levels, these analyses have limited clinical relevance. Iron, ferritin, and transferrin levels were known in at least 50% of patients but did not correlate with plasma BMP6 levels. In conclusion, this study showed normal BMP6 plasma levels in SIRS, which are reduced in patients with sepsis and septic shock. This suggests that the commonly observed increase in hepcidin levels and the decline in iron levels in SIRS, sepsis, and septic shock are not due to higher BMP6.
Homotrypa Ulrich 1882
Creators: name: Ernst, Andrej
name: Carrera, Marcelo G.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Stenolaemata
Trepostomatida
Monticuliporidae
Homotrypa

description: Genus Homotrypa Ulrich, 1882
TYPE SPECIES. — Homotrypa curvata Ulrich, 1882 by original designation. Cincinnatian, Upper Ordovician; North America.
DIAGNOSIS. — Ramose and frondose colonies, often flattened, sometimes encrusting and irregularly massive in initial stages. Autozooecia with polygonal, rounded or oval apertures. Walls slightly thickened in exozone, integrate, diagonally and longitudinally laminated. Cystiphragms only in exozone, diaphragms commonly in exozone. Mesozooecia from rare to abundant, sometimes clustering in maculae. Acanthostyles abundant, commonly small.
OCCURRENCE. — Middle Ordovician to Lower Silurian; North America, Europe, Australia, Siberia.
COMPARISON
The genus Homotrypa Ulrich, 1882 differs from the genus Monticulipora d’Orbigny, 1850 by its branched erect colony instead of the encrusting or massive one in Monticulipora. Furthermore, cystiphragms in Homotrypa are usually concentrated in the inner exozone, whereas cystiphragms in Monticulipora occur throughout autozooecial chambers.
description: Published as part of Ernst, Andrej & Carrera, Marcelo G., 2022, A cool-water bryozoan association from the La Pola Formation (Sandbian, Ordovician) of Argentine Precordillera, pp. 563-601 in Geodiversitas 44 (20) on page 572, DOI: 10.5252/geodiversitas2022v44a20, http://zenodo.org/record/6725916
Microakodontomys transitorius Hershkovitz 1993
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microakodontomys
Microakodontomys transitorius

description: Microakodontomys transitorius Hershkovitz 1993
Microakodontomys transitorius Hershkovitz 1993, Fieldiana Zool., n. s., 75: 2.
Type Locality: Brazil, Federal District, Parque Nacional de Brasília, ca. 20 km NW Brasília, 1100 m; 15º47′S, 47º55′W.
Vernacular Names: Transitional Colilargo.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
Erwartungen und Anfragen eines Laien an die Orden als geistliche Gemeinschaften
Creators: name: Kreitmeir, Hermann Josef
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Microryzomys Thomas 1917
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microryzomys

description: Microryzomys Thomas 1917
Microryzomys Thomas 1917, Smithson. Misc. Coll., 68: 1.
Type Species: Hesperomys minutus Tomes 1860
Synonyms: Thallomyscus Thomas 1926.
Species and subspecies: 2 species:
Species Microryzomys altissimus Osgood 1933
Species Microryzomys minutus (Tomes 1860)
Discussion: Oryzomyini. Named as a subgenus of Oryzomys and either retained as such (Cabrera, 1961; Ellerman, 1941; Osgood, 1933 a) or placed in synonymy with Oligoryzomys (Gyldenstolpe, 1932; Tate, 1932 e; Thomas, 1926). Junior synonymy of Thallomyscus established by Osgood (1933 a). Raised to genus by Carleton and Musser (1984) and later revised by them (1989). Cladistically primitive member of Oryzomyini, sharing certain morphological traits with Oligoryzomys (Carleton and Musser, 1989; Carleton and Olson, 1999); sister genus to Neacomys according to gene sequence studies (Myers et al., 1995; Patton and da Silva, 1995; Smith and Patton, 1999) or to the Neacomys Oligoryzomys clade according to allozymic analyses (Dickerman and Yates, 1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
Repetitive combined doses of bacteriophages and gentamicin protect against Staphylococcus aureus implant-related infections in Galleria mellonella
Creators: name: Mannala, Gopala Krishna
name: Rupp, Markus
name: Walter, Nike
name: Youf, Raphaëlle
name: Bärtl, Susanne
name: Riool, Martijn
name: Alt, Volker
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Galleria mellonella; Staphylococcus aureus; Bacteriophages; implant-related; infections; gentamicin; Kirschner wire (K-wire); biofilms; infections; bacteria; haematogenous infection; survival analysis; log-rank test
subject: 610 Medizin

description: Abstract
Aims

Bacteriophages infect, replicate inside bacteria, and are released from the host through lysis. Here, we evaluate the effects of repetitive doses of the Staphylococcus aureus phage 191219 and gentamicin against haematogenous and early-stage biofilm implant-related infections in Galleria mellonella.
Methods

For the haematogenous infection, G. mellonella larvae were implanted with a Kirschner wire (K-wire), infected with S. aureus, and subsequently phages and/or gentamicin were administered. For the early-stage biofilm implant infection, the K-wires were pre-incubated with S. aureus suspension before implantation. After 24 hours, the larvae received phages and/or gentamicin. In both models, the larvae also received daily doses of phages and/or gentamicin for up to five days. The effect was determined by survival analysis for five days and quantitative culture of bacteria after two days of repetitive doses.
Results

In the haematogenous infection, a single combined dose of phages and gentamicin, and repetitive injections with gentamicin or in combination with phages, resulted in significantly improved survival rates. In the early-stage biofilm infection, only repetitive combined administration of phages and gentamicin led to a significantly increased survival. Additionally, a significant reduction in number of bacteria was observed in the larvae after receiving repetitive doses of phages and/or gentamicin in both infection models.
Conclusion

Based on our results, a single dose of the combination of phages and gentamicin is sufficient to prevent a haematogenous S. aureus implant-related infection, whereas gentamicin needs to be administered daily for the same effect. To treat early-stage S. aureus implant-related infection, repetitive doses of the combination of phages and gentamicin are required.
Microryzomys altissimus Osgood 1933
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microryzomys
Microryzomys altissimus

description: Microryzomys altissimus Osgood 1933
Microryzomys altissimus Osgood 1933, Field Mus. Nat. Hist. Publ., Zool. Ser., 20: 5.
Type Locality: Perú, Pasco Dept., La Quinua, mountains north of Cerro de Pasco, 11,600 ft (3536 m).
Vernacular Names: Paramo Colilargo.
Synonyms: Microryzomys chotanus Hershkovitz 1940; Microryzomys hylaeus Hershkovitz 1940.
Distribution: Subalpine and páramo formations, mostly 2500-4000 m, in the Andes of Colombia, Ecuador, and Perú.
Conservation: IUCN – Lower Risk (lc).
Discussion: Diagnosed as a subspecies of Oryzomys minutus but elevated to species by Hershkovitz (1940), who named two additional subspecies. Subspecific arrangement followed by Cabrera (1961) but none retained by Carleton and Musser (1989).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
La doppia eccedenza
Creators: name: Guglielminetti, Enrico
Publisher: name: Spazio Filosofico
Year: 2015

description: Superabundance is appropriate to festivals and holidays. When they are successful, festivals and holidays are meant to go on. Thus, “Spazio Filosofico” continues with the same concept once again, like Scheherazade, who does not stop narrating, and adds ever new contents to her stories.
description: Spazio Filosofico, 15. Festa II
Navigating Life with Posterior Urethral Valves—Sexual Health and Lower Urinary Tract Symptoms
Creators: name: Zöhrer, Pirmin I.
name: Vauth, Franziska
name: Jaekel, Anke K.
name: Rösch, Wolfgang H.
name: Hofmann, Aybike
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: congenital lower urinary tract obstruction; incontinence; self-efficacy; kidney function; relationship
subject: 610 Medizin

description: Background: Quality of life (QoL) is crucial for young adults with posterior urethral valves (PUV). This study investigates the impact of lower urinary tract symptoms (LUTS) on their quality of life and sexual health, including self-efficacy. Methods: Patients aged 16 and older treated for PUV completed four validated questionnaires (Sexual Self-Efficacy Scale (SSES-E), ICIQ MLUTS, ICIQ MLUTSsex, ICIQ LUTSqol) and an individual health questionnaire. Results: Eighteen (52.9%) patients responded, with a median age of 23 years (IQR 18–26). Three had terminal renal failure; two were transplanted. Thirteen urinated naturally; five used a stoma. Sixteen had mild and two had moderate LUTS. Fifteen patients completed the SSES-E, scoring an average of 80, similar to the healthy cohort (83). Renal failure or catheterization did not significantly affect the overall score. In the ICIQ MLUTSsex, patients reported no significant impact of LUTS on sexuality. However, those with moderate LUTS had lower self-efficacy than those with mild symptoms (mean 75 vs. 84). Conclusions: Although quality of life and sexual function do not appear to be significantly impaired, LUTS are common and appear to be associated with a decreased SSE in our cohort. This should be particularly considered during the transition to adult care.
Microryzomys minutus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microryzomys
Microryzomys minutus

description: Microryzomys minutus (Tomes 1860)
[Hesperomys] minutus Tomes 1860, Proc. Zool. Soc. Lond., 1860: 215.
Type Locality: Ecuador, Chimborazo Prov., probably near Pallatanga.
Vernacular Names: Montane Colilargo.
Synonyms: Microryzomys aurillus (Thomas 1917); Microryzomys dryas (Thomas 1898); Microryzomys fulvirostris (J. A. Allen 1912); Microryzomys humilior (Thomas 1898).
Distribution: Lower montane to subalpine forest, mostly 2000-3500 m, from N Venezuela, through Colombia, Ecuador and Perú, to WC Bolivia.
Conservation: IUCN – Lower Risk (lc).
Discussion: Formerly included altissimus as a subspecies by Osgood (1933 a), who also treated aurillus, humilior, and fulvirostris as subspecies. No races were deemed diagnosable by Carleton and Musser (1989).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
Double Excess
Creators: name: Guglielminetti, Enrico
Publisher: name: Spazio Filosofico
Year: 2015

description: Superabundance is appropriate to festivals and holidays. When they are successful, festivals and holidays are meant to go on. Thus, “Spazio Filosofico” continues with the same concept once again, like Scheherazade, who does not stop narrating, and adds ever new contents to her stories.
description: Spazio Filosofico, 15. Festa II
Homotrypa subramosa Ulrich 1886
Creators: name: Ernst, Andrej
name: Carrera, Marcelo G.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Stenolaemata
Trepostomatida
Monticuliporidae
Homotrypa
Homotrypa subramosa

description: Homotrypa subramosa Ulrich, 1886
(Fig. 7 A-C; Appendix 1)
Homotrypa subramosa Ulrich, 1886: 81; 1893: 239-340, pl. 19, figs 21- 28. — Bassler 1911: 187-189, text-figs 99-100. — Bork & Perry 1968: 1053-1055, pl. 136, figs 1-3. — McKinney 1971: 234-237, pl. 49, fig. 4-8, pl. 50, fig. 1. — Marintsch 1998: 53-55, pl. 9, figs 1-5.
Homotrypa insignis Ulrich, 1886: 82.
MATERIAL EXAMINED. — CEGH-UNC 27516 a, d, CEGH-UNC 27519 a, b, CEGH-UNC 27530 a-g, CEGH-UNC 27531 b, CEGH-UNC 27536 a, CEGH-UNC 27537 a, b, CEGH-UNC 27542 a, c, d, e, CEGH-UNC 27545b.
DESCRIPTION
Irregularly branched, submassive or encrusting colony. Branches and fronds 5.6-9.4 mm thick, encrusting sheets 0.7-1.6 mm thick. Exozones indistinct. Autozooecia prismatic, growing for long distance along branch axis and bending gently to the colony surface. Autozooecial diaphragms common, thin, planar. Autozooecial apertures polygonal in tangential section. Cystiphragms abundant, densely spaced, constricting middle part of zooecia, about a half of their diameter. Mesozooecia few, polygonal. Autozooecial walls granular, 0.003 -0.005 mm thick in endozone; amalgamated, 0.02-0.03 mm thick in exozone. Acanthostyles few, small to moderate in size. Maculae consisting of macrozooecia, 0.80-0.95 mm in diameter.
COMPARISON
Homotrypa subramosa Ulrich, 1886 differs from H. callosa Ulrich, 1893 in larger autozooecial apertures (average aperture width 0.16 mm vs 0.14 mm in H. callosa; measurements for H.callosa from Marintsch, 1998). Homotrypa subramosa Ulrich, 1886 differs from H.tuberculata Ulrich, 1893 in less abundant and smaller acanthostyles and in smaller autozooecial apertures (average aperture width 0.16 mm vs 0.20 mm in H. tuberculata; measurements for H. tuberculata from Marintsch 1998).
description: Published as part of Ernst, Andrej & Carrera, Marcelo G., 2022, A cool-water bryozoan association from the La Pola Formation (Sandbian, Ordovician) of Argentine Precordillera, pp. 563-601 in Geodiversitas 44 (20) on pages 572-574, DOI: 10.5252/geodiversitas2022v44a20, http://zenodo.org/record/6725916
Neacomys Thomas 1900
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Neacomys

description: Neacomys Thomas 1900
Neacomys Thomas 1900, Ann. Mag. Nat. Hist., ser. 7, 5: 153.
Type Species: Hesperomys spinosus Thomas 1882
Species and subspecies: 8 species:
Species Neacomys dubosti Voss, Lunde, and Simmons 2001
Species Neacomys guianae Thomas 1905
Species Neacomys minutus Patton, da Silva, and Malcolm 2000
Species Neacomys musseri Patton, da Silva, and Malcolm 2000
Species Neacomys paracou Voss, Lunde, and Simmons 2001
Species Neacomys pictus Goldman 1912
Species Neacomys spinosus (Thomas 1882)
Species Neacomys tenuipes Thomas 1900
Discussion: Oryzomyini. Sister genus to Microryzomys according to gene sequence studies (Myers et al., 1995; Patton and da Silva, 1995; Smith and Patton, 1999; Weksler, 2003) or to Oligoryzomys according to allozymic analyses (Dickerman and Yates, 1995). Recent taxonomic descriptions and detailed regional comparisons have markedly improved understanding of species diversity and their morphological discrimination (Patton et al., 2000; Voss et al., 2001). Delineation of yet other species and enhancement of distributional limits still required (e.g., see Malygin and Rosmiarek, 1996; Patton et al., 2000). Preliminary molecular geographic patterns discerned by Patton et al. (2000) offer a template for future taxonomic studies.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1126, DOI: 10.5281/zenodo.7316535
Managing more than bones: the psychological impact of a recurrent fracture-related infection
Creators: name: Walter, Nike
name: Loew, Thomas
name: Hinterberger, Thilo
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Fracture-related infection; Mental health; Patient-reported outcome measures; Psychological symptoms; fracture-related infections (FRIs); infections; depression scores; Anxiety scores; trauma; t-tests; depression; anxiety; Open fractures; comorbidities
subject: 610 Medizin

description: Aims

Fracture-related infections (FRIs) are a devastating complication of fracture management. However, the impact of FRIs on mental health remains understudied. The aim of this study was a longitudinal evaluation of patients’ psychological state, and expectations for recovery comparing patients with recurrent FRI to those with primary FRI.
Methods

A prospective longitudinal study was conducted at a level 1 trauma centre from January 2020 to December 2022. In total, 56 patients treated for FRI were enrolled. The ICD-10 symptom rating (ISR) and an expectation questionnaire were assessed at five timepoints: preoperatively, one month postoperatively, and at three, six, and 12 months.
Results

Recurrent FRI cases consistently exceeded the symptom burden threshold (0.60) in ISR scores at all assessment points. The difference between preoperative-assessed total ISR scores and the 12-month follow-up was not significant in either group, with 0.04 for primary FRI (p = 0.807) and 0.01 for recurrent FRI (p = 0.768). While primary FRI patients showed decreased depression scores post surgery, recurrent FRI cases experienced an increase, reaching a peak at 12 months (1.92 vs 0.94; p < 0.001). Anxiety scores rose for both groups after surgery, notably higher in recurrent FRI cases (1.39 vs 1.02; p < 0.001). Moreover, patients with primary FRI reported lower expectations of returning to normal health at three (1.99 vs 1.11; p < 0.001) and 12 months (2.01 vs 1.33; p = 0.006).
Conclusion

The findings demonstrate the significant psychological burden experienced by individuals undergoing treatment for FRI, which is more severe in recurrent FRI. Understanding the psychological dimensions of recurrent FRIs is crucial for comprehensive patient care, and underscores the importance of integrating psychological support into the treatment paradigm for such cases.
Unraveling Cancer’s Wnt Signaling: Dynamic Control through Protein Kinase Regulation
Creators: name: Tümen, Deniz
name: Heumann, Philipp
name: Huber, Juliette
name: Hahn, Nele
name: Macek, Celina
name: Ernst, Martha
name: Kandulski, Arne
name: Kunst, Claudia
name: Gülow, Karsten
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Wnt signaling; canonical; non-canonical; β-catenin; planar-cell-polarity; Ca2+ signaling; kinases; phosphorylation; cancer; cancer-therapy
subject: 610 Medizin

description: Since the initial identification of oncogenic Wnt in mice and Drosophila, the Wnt signaling
pathway has been subjected to thorough and extensive investigation. Persistent activation of Wnt
signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell
senescence, cell death, differentiation, and metastasis. Here we review the principal signaling
mechanisms and the regulatory influence of pathway-intrinsic and extrinsic kinases on cancer
progression. Additionally, we underscore the divergences and intricate interplays of the canonical
and non-canonical Wnt signaling pathways and their critical influence in cancer pathophysiology,
exhibiting both growth-promoting and growth-suppressing roles across diverse cancer types.
Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity
Creators: name: Brummer, Christina
name: Singer, Katrin
name: Brand, Almut
name: Bruss, Christina
name: Renner, Kathrin
name: Herr, Wolfgang
name: Pukrop, Tobias
name: Dorn, Christoph
name: Hellerbrand, Claus
name: Matos, Carina
name: Kreutz, Marina
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: obesity; gender; sex; inflammation; immune cell dysregulation; T cell; MDSC; female; male; cancer
subject: 610 Medizin
subject: 615 Pharmazie

description: Obesity is an emerging public health problem. Chronic low-grade inflammation is considered a major promotor of obesity-induced secondary diseases such as cardiovascular and fatty liver disease, type 2 diabetes mellitus, and several cancer entities. Most preliminary studies on obesity-induced immune responses have been conducted in male rodents. Sex-specific differences between men and women in obesity-induced immune dysregulation have not yet been fully outlined but are highly relevant to optimizing prevention strategies for overweight-associated complications. In this study, we fed C57BL/6 female vs. male mice with either standard chow or an obesity-inducing diet (OD). Blood and spleen immune cells were isolated and analyzed by flow cytometry. Lean control mice showed no sex bias in systemic and splenic immune cell composition, whereas the immune responses to obesity were significantly distinct between female and male mice. While immune cell alterations in male OD mice were characterized by a significant reduction in T cells and an increase in myeloid-derived suppressor cells (MDSC), female OD mice displayed preserved T cell numbers. The sex-dependent differences in obesity-induced T cell dysregulation were associated with varying susceptibility to body weight gain and fatty liver disease: Male mice showed significantly more hepatic inflammation and histopathological stigmata of fatty liver in comparison to female OD mice. Our findings indicate that sex impacts susceptibility to obesity-induced T cell dysregulation, which might explain sex-dependent different incidences in the development of obesity-associated secondary diseases. These results provide novel insights into the understanding of obesity-induced chronic inflammation from a sex-specific perspective. Given that most nutrition, exercise, and therapeutic recommendations for the prevention of obesity-associated comorbidities do not differentiate between men and women, the data of this study are clinically relevant and should be taken into consideration in future trials and treatment strategies.
Eupolybothrus syngenes Chamberlin, 1952, sp. n.
Creators: name: R. V. Chamberlin
Publisher: name: Zenodo
Year: 1952
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Chilopoda
Lithobiomorpha
Lithobiidae
Eupolybothrus
Eupolybothrus syngenes

description: Eupolybothrus syngenes sp. n.
Dorsum brownish yellow, a median dorsal stripe and caudal border or corners and lateral edges of some tergites blackish much as in the much larger acigolensis.
Articles of antennae, 40. Ocelli 1+3,4,3, the caudal ocellus of bottom series below the single ocellus which is contiguous with caudal ocellus of second series.
Prosternal teeth, 7+7.
Leg I with ventral spines 0,0,2,3,1; dorsal, 0,0,2,1,1. Penult legs with ventral spines 0,1,3,3,2; dorsal, 1,0,3,1,1. Anal legs with ventral spines 0,1,3,2,1; dorsal, 1,0,3,1,0; claws 2. None of the coxae laterally armed.
Fifteenth tergite with caudal margin slightly incurved in the male, with corners rounded. Genital sternite of the male with caudal margin obtusely indented at the middle, on each side widely and moderately convex. (See Figs. 24 and 25.)
Femur of the anal legs of the male with the usual dorsal longitudinal furrow; without notable swelling at distal end; no fine-pore area proximad of dorsal spine at distal end; pore-free area only a fourth, or but little more, the length of the joint.
Length, 18 mm.
Locality: Yalova (near Istanbul, Asiatic side), one male taken May 9, 1948.
description: Published as part of R. V. Chamberlin, 1952, On the Chilopoda from Turkey, pp. 183-258 in Istanbul Universitesi Orman Fakültesi Dergisi 17 on page 221
The law code of ChatGPT and artificial intelligence—how to shield plastic surgeons and reconstructive surgeons against Justitia's sword
Creators: name: Knoedler, Leonard
name: Vogt, Alexander
name: Alfertshofer, Michael
name: Camacho, Justin M.
name: Najafali, Daniel
name: Kehrer, Andreas
name: Prantl, Lukas
name: Iske, Jasper
name: Dean, Jillian
name: Hoefer, Simon
name: Knoedler, Christoph
name: Knoedler, Samuel
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: ChatGPT, artificial intelligence, AI, chatbots, law, legal, lawsuits, litigation
subject: 610 Medizin

description: Large Language Models (LLMs) like ChatGPT 4 (OpenAI), Claude 2 (Anthropic), and Llama 2 (Meta AI) have emerged as novel technologies to integrate artificial intelligence (AI) into everyday work. LLMs in particular, and AI in general, carry infinite potential to streamline clinical workflows, outsource resource-intensive tasks, and disburden the healthcare system. While a plethora of trials is elucidating the untapped capabilities of this technology, the sheer pace of scientific progress also takes its toll. Legal guidelines hold a key role in regulating upcoming technologies, safeguarding patients, and determining individual and institutional liabilities. To date, there is a paucity of research work delineating the legal regulations of Language Models and AI for clinical scenarios in plastic and reconstructive surgery. This knowledge gap poses the risk of lawsuits and penalties against plastic surgeons. Thus, we aim to provide the first overview of legal guidelines and pitfalls of LLMs and AI for plastic surgeons. Our analysis encompasses models like ChatGPT, Claude 2, and Llama 2, among others, regardless of their closed or open-source nature. Ultimately, this line of research may help clarify the legal responsibilities of plastic surgeons and seamlessly integrate such cutting-edge technologies into the field of PRS.
Neacomys dubosti Voss, Lunde, and Simmons 2001
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Neacomys
Neacomys dubosti

description: Neacomys dubosti Voss, Lunde, and Simmons 2001
Neacomys dubosti Voss, Lunde, and Simmons 2001, Bull. Am. Nat. Hist., 263: 78.
Type Locality: French Guiana, Paracou.
Vernacular Names: Dubost's Neacomys.
Distribution: SE Surinam, French Guiana, and Amapá, Brazil.
Discussion: Morphological comparisons with N. guianae, N. paracou, and N. tenuipes provided by Voss et al. (2001). Known sympatrically with N. guianae and N. paracou.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1127, DOI: 10.5281/zenodo.7316535
HGSHS-5:G—First results with the short version of the test for the Harvard Group Scale of Hypnotic Susceptibility and a comparison with the full version
Creators: name: Zech, Nina
name: Riegel, Bjoern
name: Rasch, Bjoern
name: Peter, Burkhard
name: Hansen, Ernil
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: hypnotic susceptibility, hypnotic suggestibility, hypnotizability, HGSHS, score distribution, suggestibility groups, normal distribution
subject: 610 Medizin

description: Introduction: The HGSHS:A is one of the most commonly used measures of
hypnotic suggestibility. However, this test suffers from low feasibility due to a
time requirement exceeding 1 h, and from a questionable representation of the
normal population. Recently, a short version of HGSHS-5:G was developed and
published, and now the first results are available. The scope of this investigation
was to verify the assumption of equally positioned and normally distributed
scores, resulting in equally sized suggestibility groups in a number of different
studies with full or short versions of HGSHS, and to compare the results of the
11-item score with the 5-item score, the latter being calculated from either the
full version or the short version test.
Methods: Data from 21 studies with testing for HGSHS were analyzed, 15 using
the HGSHS:A full version and six using the HGSHS-5:G short version, for a total
of 2,529 data sets. Position and distribution of both the 11-item score and the
5-item score were tested. Linear regression analysis was used to compare the
two scores, as well as cross-table and weighted Cohen’s kappa to determine
the match of grouping into low and high suggestibility. To evaluate contributing
factors to the observed differences in the study results, a multifactorial analysis
of variance was performed.
Results: In the different studies, position and distribution of scores, as well as
group sizes for low and high suggestibles, varied. All score distributions were
found to be non-normal and shifted to the right from the middle score; the shift
was more extensive with the 11-item score. The correlation between both scores
calculated from full version tests was moderate (R2 = 0.69), as was the match
of suggestibility grouping (κ = 0.58). Studies using the short version involving
less student-dominated populations showed sufficient agreement with the full
version, but lower scores were caused by an increase in the zero score.
Conclusion: A normal population is not represented in most applications of
HGSHS, and grouping into low and high suggestibles varies, mainly due to
different positions of score distributions. A direct comparison of full and short
versions of HGSHS tested in the same subjects is still missing.
[18F]FDG PET/CT Imaging Is Associated with Lower In-Hospital Mortality in Patients with Pyogenic Spondylodiscitis—A Registry-Based Analysis of 29,362 Cases
Creators: name: Lang, Siegmund
name: Walter, Nike
name: Heidemanns, Stefanie
name: Lapa, Constantin
name: Schindler, Melanie
name: Krueckel, Jonas
name: Schmidt, Nils Ole
name: Hellwig, Dirk
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: spondylodiscitis; vertebral osteomyelitis; [18F]FDG PET/CT; in-hospital mortality; elderly patients
subject: 610 Medizin

description: Background: While MRI is the primary diagnostic tool for the diagnosis of spondylodiscitis, the role of [18F]-fluorodeoxyglucose ([18F]FDG) PET/CT is gaining prominence. This study aimed to determine the frequency of [18F]FDG PET/CT usage and its impact on the in-hospital mortality rate in patients with spondylodiscitis, particularly in the geriatric population. Methods: We conducted a Germany-wide cross-sectional study from 2019 to 2021 using an open-access, Germany-wide database, analyzing cases with ICD-10 codes M46.2-, M46.3-, and M46.4- (‘Osteomyelitis of vertebrae’, ‘Infection of intervertebral disc (pyogenic)’, and ‘Discitis unspecified’). Diagnostic modalities were compared for their association with in-hospital mortality, with a focus on [18F]FDG PET/CT. Results: In total, 29,362 hospital admissions from 2019 to 2021 were analyzed. Of these, 60.1% were male and 39.9% were female, and 71.8% of the patients were aged 65 years and above. The overall in-hospital mortality rate was 6.5% for the entire cohort and 8.2% for the geriatric subgroup (p < 0.001). Contrast-enhanced (ce) MRI (48.1%) and native CT (39.4%) of the spine were the most frequently conducted diagnostic modalities. [18F]FDG PET/CT was performed in 2.7% of cases. CeCT was associated with increased in-hospital mortality (OR = 2.03, 95% CI: 1.90–2.17, p < 0.001). Cases with documented [18F]FDG PET/CT showed a lower frequency of in-hospital deaths (OR = 0.58, 95% CI: 0.18–0.50; p = 0.002). This finding was more pronounced in patients aged 65 and above (OR = 0.42, 95% CI: 0.27–0.65, p = 0.001). Conclusions: Despite its infrequent use, [18F]FDG PET/CT was associated with a lower in-hospital mortality rate in patients with spondylodiscitis, particularly in the geriatric cohort. This study is limited by only considering data on hospitalized patients and relying on the assumption of error-free coding. Further research is needed to optimize diagnostic approaches for spondylodiscitis.
Homotrypa vacua McKinney 1971
Creators: name: Ernst, Andrej
name: Carrera, Marcelo G.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Stenolaemata
Trepostomatida
Monticuliporidae
Homotrypa
Homotrypa vacua

description: Homotrypa vacua McKinney, 1971
(Fig. 7 D-I; Appendix 1)
Homotrypa vacua McKinney, 1971: 238-241, pl. 50, figs 2-7. — Pushkin 1987: 186.
MATERIAL EXAMINED. — CEGH-UNC 27507 c, CEGH-UNC 27525 a, CEGH-UNC 27529 a, CEGH-UNC 27530 a, b, d-g, CEGH-UNC 27533 d, CEGH-UNC 27541 a, CEGH-UNC 27545 a.
OCCURRENCE. — Lower Chickamauga Group, Upper Ordovician, Sandbian; Alabama, United States. La Pola Formation, Upper Ordovician, Sandbian; La Pola creek section near Albardon village, San Juan Province, Argentine Precordillera, western Argentina.
DESCRIPTION
Ramose colonies, branch diameter 1.45-2.38 mm. Endozone 0.60-1.45 mm wide, exozone 0.25-0.75 mm wide, distinct. Secondary overgrowths not observed. Autozooecia long in the endozone, having larger diameters than in exozone, bending gently and intersecting branch surface at low angles. Autozooecial apertures rounded-polygonal. Autozooecial diaphragms rare to absent in the endozone, concentrated mostly in transitional region between endo- and exozone, common to abundant in outer exozone.Cystiphragms occurring throughout the exozone, occupying about the half of autozooecial diameter. Mesozooecia locally 3-5 surrounding each autozooecial aperture, otherwise rare; small, short, restricted to the outermost part of exozone, containing densely spaced diaphragms. Acanthostyles common, 2-5 surrounding each autozooecial aperture, moderately large, restricted to exozone. Autozooecial walls straight, displaying granular microstructure, 0.003 -0.005 mm thick in endozone; finely laminated with indistinct medial line, 0.023 -0.055 mm thick in exozone. Indistinct maculae consisting of macrozooecia.
COMPARISON
Homotrypa vacua McKinney, 1971 differs from H. mundula (Ulrich, 1893) in having smaller colonies (branch diameter 1.45-2.38 mm vs 3.6-4.0 in H. mundula, measurements from Karklins [1984: 134]). Homotrypa vacua differs from H. subramosa Ulrich, 1886 in having thin branched colonies instead subramose and encrusting ones as well as in smaller autozooecial apertures (average aperture width 0.11 mm vs 0.16 mm in H. subramosa).
description: Published as part of Ernst, Andrej & Carrera, Marcelo G., 2022, A cool-water bryozoan association from the La Pola Formation (Sandbian, Ordovician) of Argentine Precordillera, pp. 563-601 in Geodiversitas 44 (20) on page 574, DOI: 10.5252/geodiversitas2022v44a20, http://zenodo.org/record/6725916
Il rituale e il sacro. Riflessioni per l’antropologia della formazione dell’ideale
Creators: name: Joas, Hans
Publisher: name: Spazio Filosofico
Year: 2015

description: When the two oppositional pairs sacred/profane and religious/profane are not mixed up, then an anthropological (and not merely religious) analysis of rituals becomes possible. The essay carries out such a detailed analysis and examines the subsequent developments from Durkheim to Habermas. From this one can derive meaningful elements for understanding the formation of ideals and, more generally, the relation between ordinary life and life-transcending experiences.
description: Spazio Filosofico, 15. Festa II
Neacomys guianae Thomas 1905
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Neacomys
Neacomys guianae

description: Neacomys guianae Thomas 1905
Neacomys guianae Thomas 1905, Ann. Mag. Nat. Hist., ser. 7, 16: 310.
Type Locality: Guyana, Demerara River, 120 ft (37 m).
Vernacular Names: Guianan Neacomys.
Distribution: Guianas, S Venezuela, and N Brazil.
Conservation: IUCN – Lower Risk (lc).
Discussion: Morphological comparisons with N. dubosti, N. paracou, and N. tenuipes provided by Voss et al. (2001). Known sympatrically with N. dubosti and N. paracou.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1127, DOI: 10.5281/zenodo.7316535
Warten auf ein Fest
Creators: name: Macho, Thomas
Publisher: name: Spazio Filosofico
Year: 2015

description: On the basis of the definition of human beings as beings who await and thus gain time, the essay examines the aporias of the wait within the Christian tradition, namely: the attempt at distinguishing the wait for a forthcoming event and the wait tout court, the re-interpretation of Jesus’ promise to come soon in the sense of an encounter with him after death, the intertwining of millenarism and disappointment, up to the paradoxical re-reading of the wait in Waiting for Godot.
description: Spazio Filosofico, 15. Festa II
Heterotrypa Nicholson 1879
Creators: name: Ernst, Andrej
name: Carrera, Marcelo G.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Stenolaemata
Trepostomatida
Heterotrypidae
Heterotrypa

description: Genus Heterotrypa Nicholson, 1879
TYPE SPECIES. — Monticulipora frondosa d’Orbigny, 1850 by subsequent designation (Utgaard & Boardman 1965). Cincinnatian, Upper Ordovician; North America.
DIAGNOSIS. — Colonies frondose, ramose or less commonly encrusting. Autozooecial walls can be extremely variable in thickness. Zooecial boundary is a conspicuous dark line in inner exozones and in a broad zone of abutting laminae or completely obscured in outer exozones. Walls generally are amalgamate in appearance. Diaphragms are generally few in endozones, but are moderately abundant in some species. In exozones, diaphragms are closely and regularly spaced, thin, planar and perpendicular to the zooecial walls. Intermonticular mesozooecia range from abundant and regularly arranged to scattered or absent. Mesozooecia develop commonly moniliform chambers at proximal ends and tend to become smaller or are terminated distally within exozones. Diaphragms in mesozooecia noticeably thicker and more closely spaced than zooecial diaphragms. Acanthostyles are at least two kinds within the genus, regular acanthostyles limited to exozone, and the endacanthostyles originating in both endozone and exozone. Endacanthostyles occur in all species. Monticules generally have a central cluster of a few mesozooecia than those in the intermonticular area.
OCCURRENCE. — Middle Ordovician-?Devonian; worldwide.
COMPARISON
The genus Heterotrypa Nicholson, 1879 differs from the genus Leioclema Ulrich, 1882 by abundant diaphragms in autozooecia, more angular apertural shape and two kinds of acanthostyles.
description: Published as part of Ernst, Andrej & Carrera, Marcelo G., 2022, A cool-water bryozoan association from the La Pola Formation (Sandbian, Ordovician) of Argentine Precordillera, pp. 563-601 in Geodiversitas 44 (20) on page 574, DOI: 10.5252/geodiversitas2022v44a20, http://zenodo.org/record/6725916
“Ein Fest, das mich nicht liebt”
Creators: name: Salmann, Elmar
Publisher: name: Spazio Filosofico
Year: 2015

description: The essay pays close attention to moments of ambivalence within holidays that can be valued also from a theological perspective. On the basis of childhood memories of happiness and delusion connected with Christmas, the essay poetically clarifies dimensions of holidays such as dream and trauma, interruption and threshold, shared memory, void and fullness.
description: Spazio Filosofico, 15. Festa II