cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
openaccess.nrw – auf dem Weg zu einer landesweiten Servicestruktur für Open Access
Creators: name: Schulz, Katharina
name: Krone, Nadja
name: Ilg, Karin
Publisher: name: Zenodo
Year: 2020
Subjects: Open-Access-Services
openaccess.nrw
Landesinitiative NRW

description: Das vom Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen (MKW NRW) über die Digitale Hochschule NRW (DH.NRW) geförderte Vorprojekt openaccess.nrw startete am 1. Oktober 2019. Bis Ende des Jahres 2020 untersucht ein Konsortium aus drei Universitäten (Bielefeld, Duisburg-Essen, Siegen), zwei Fachhochschulen (FH Bielefeld, TH Köln) und dem Hochschulbibliothekszentrum des Landes NRW (hbz) die Servicebedarfe der NRW-Hochschulen im Bereich Open Access. Die Hochschulbibliothek der FH Bielefeld koordiniert das Projekt.
 openaccess.nrw zielt darauf ab, die Voraussetzungen, Bedarfe und Umsetzungsoptionen für die Implementierung einer landesweiten digitalen Servicestruktur der NRW-Hochschulen und des hbz im Bereich Open Access zu klären. Anhand qualitativer und quantitativer Erhebungen wird beleuchtet, welche Open-Access-Services im NRW-Hochschulbereich bereits vorhanden sind und wie diese genutzt werden.
 Aufbauend auf den Ergebnissen der Erhebungen werden in einem zweiten Schritt Empfehlungen für ein Portfolio zentral oder dezentral bereitzustellender Services erarbeitet. Diese können (technische) Infrastrukturservices ebenso umfassen wie Dienstleistungen im Bereich Information, Beratung und Qualifizierung.
 Auf diesem Poster werden die Kernfragen, die Zielsetzung und die Meilensteine dieses Vorprojekts dargestellt.
Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children's Study (NCS)
Creators: name: Li, Qian
name: A Kappil, Maya
name: Li, An
name: S Dassanayake, Priyanthi
name: H Darrah, Thomas
name: E Friedman, Alan
name: Friedman, Michelle
name: Lambertini, Luca
name: Landrigan, Philip
name: J Stodgell, Christopher
name: Xia, Yulin
name: A Nanes, Jessica
name: M Aagaard, Kjersti
name: E Schadt, Eric
name: C Murray, Jeff
name: B Clark, Edward
name: Dole, Nancy
name: Culhane, Jennifer
name: Swanson, James
name: Varner, Michael
name: Moye, Jack
name: Kasten, Carol
name: K Miller, Richard
name: Chen, Jia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The placenta is the principal regulator of the in utero environment, and disruptions to this environment can result in adverse offspring health outcomes. To better characterize the impact of in utero perturbations, we assessed the influence of known environmental pollutants on the expression of microRNA (miRNA) in placental samples collected from the National Children's Study (NCS) Vanguard birth cohort. This study analyzed the expression of 654 miRNAs in 110 term placentas. Environmental pollutants measured in these placentas included dichlorodiphenyldichloroethylene (DDE), bisphenol A (BPA), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), arsenic (As), mercury (Hg), lead (Pb), and cadmium (Cd). A moderated t-test was used to identify a panel of differentially expressed miRNAs, which were further analyzed using generalized linear models. We observed 112 miRNAs consistently expressed in >70% of the samples. Consistent with the literature, miRNAs located within the imprinted placenta-specific C19MC cluster, specifically mir-517a, mir-517c, mir-522, and mir-23a, are among the top expressed miRNA in our study. We observed a positive association between PBDE 209 and miR-188–5p and an inverse association between PBDE 99 and let-7c. Both PCBs and Cd were positively associated with miR-1537 expression level. In addition, multiple let-7 family members were downregulated with increasing levels of Hg and Pb. We did not observe DDE or BPA levels to be associated with placental miRNA expression. This is the first birth cohort study linking environmental pollutants and placental expression of miRNAs. Our results suggest that placental miRNA profiles may signal in utero exposures to environmental chemicals.
Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children's Study (NCS)
Creators: name: Li, Qian
name: A Kappil, Maya
name: Li, An
name: S Dassanayake, Priyanthi
name: H Darrah, Thomas
name: E Friedman, Alan
name: Friedman, Michelle
name: Lambertini, Luca
name: Landrigan, Philip
name: J Stodgell, Christopher
name: Xia, Yulin
name: A Nanes, Jessica
name: M Aagaard, Kjersti
name: E Schadt, Eric
name: C Murray, Jeff
name: B Clark, Edward
name: Dole, Nancy
name: Culhane, Jennifer
name: Swanson, James
name: Varner, Michael
name: Moye, Jack
name: Kasten, Carol
name: K Miller, Richard
name: Chen, Jia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: The placenta is the principal regulator of the in utero environment, and disruptions to this environment can result in adverse offspring health outcomes. To better characterize the impact of in utero perturbations, we assessed the influence of known environmental pollutants on the expression of microRNA (miRNA) in placental samples collected from the National Children's Study (NCS) Vanguard birth cohort. This study analyzed the expression of 654 miRNAs in 110 term placentas. Environmental pollutants measured in these placentas included dichlorodiphenyldichloroethylene (DDE), bisphenol A (BPA), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), arsenic (As), mercury (Hg), lead (Pb), and cadmium (Cd). A moderated t-test was used to identify a panel of differentially expressed miRNAs, which were further analyzed using generalized linear models. We observed 112 miRNAs consistently expressed in >70% of the samples. Consistent with the literature, miRNAs located within the imprinted placenta-specific C19MC cluster, specifically mir-517a, mir-517c, mir-522, and mir-23a, are among the top expressed miRNA in our study. We observed a positive association between PBDE 209 and miR-188–5p and an inverse association between PBDE 99 and let-7c. Both PCBs and Cd were positively associated with miR-1537 expression level. In addition, multiple let-7 family members were downregulated with increasing levels of Hg and Pb. We did not observe DDE or BPA levels to be associated with placental miRNA expression. This is the first birth cohort study linking environmental pollutants and placental expression of miRNAs. Our results suggest that placental miRNA profiles may signal in utero exposures to environmental chemicals.
TALENT MANAGEMENT IN A DIGITAL WORLD: BUILDING WORKFORCE  AGILITY THROUGH STRATEGIC HRM
Creators: name: Mrs. Priya Borse
Publisher: name: Zenodo
Year: 2025

description: 1. Abstract The digital era has significantly transformed the workplace, driving organizations to adopt innovative strategies to remain competitive and sustainable. Talent management, a cornerstone of Strategic Human Resource Management (SHRM), is vital for addressing the challenges posed by this transformation. With the rapid advancement of technologies such as artificial intelligence (AI), machine learning, big data, and automation, traditional workforce dynamics have shifted dramatically, leading to new challenges like skills gaps, talent retention issues, and employee resistance to change. At the same time, these changes present opportunities to redefine work through flexible models, diversity, inclusion, and digital proficiency. This study explores how SHRM can empower organizations to redefine their talent management strategies to meet the demands of the digital age. By leveraging digital tools, promoting continuous learning, and fostering workforce agility, SHRM provides a framework to prepare organizations for the future of work. This research employs a mixed-methods approach, utilizing primary data collected through surveys and interviews with HR professionals and business leaders, as well as secondary data from industry-leading reports and organizational case studies.
Velociraptor-specific materials
Creators: name: Rafajko, Sean Isaac
name: Renk, Alexis
name: Wojtowicz, Rafal Adam
name: Zofie Mandelski
name: Chavez, Cynthia Jocelyn
name: Legate, Nicole
Publisher: name: OSF Registries
Year: 2016

description: Two groups, each made of four students, each will conduct a replication of this study originally done by Forest and wood (2012). The students will perform the replication study as a part of their Research Methods psychology class, led by Professor Dr. Nicole Legate and Sean Rafajko, graduate student, at the Illinois Institute of Technology (IIT) in Chicago, Illinois.
Glutathione S-transferase P1 suppresses iNOS protein stability in RAW264.7 macrophage-like cells after LPS stimulation
Creators: name: Cao, Xiang
name: Kong, Xiuqin
name: Zhou, Yi
name: Lan, Lei
name: Luo, Lan
name: Yin, Zhimin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Glutathione S-transferase P1 (GSTP1) is a ubiquitous expressed protein which plays an important role in the detoxification and xenobiotics metabolism. Previous studies showed that GSTP1 was upregulated by the LPS stimulation in RAW264.7 macrophage-like cells and GSTP1 overexpression downregulated lipopolysaccharide (LPS) induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Here we show that GSTP1 physically associates with the oxygenase domain of iNOS by the G-site domain and decreases the protein level of iNOS dimer. Both overexpression and RNA interference (RNAi) experiments indicate that GSTP1 downregulates iNOS protein level and increases S-nitrosylation and ubiquitination of iNOS. The Y7F mutant type of GSTP1 physically associates with iNOS, but shows no effect on iNOS protein content, iNOS S-nitrosylation, and changes in iNOS from dimer to monomer, suggesting the importance of enzyme activity of GSTP1 in regulating iNOS S-nitrosylation and stability. GSTM1, another member of GSTs shows no significant effect on regulation of iNOS. In conclusion, our study reveals the novel role of GSTP1 in regulation of iNOS by affecting S-nitrosylation, dimerization, and stability, which provides a new insight for analyzing the regulation of iNOS and the anti-inflammatory effects of GSTP1.
The association between job strain and coronary heart disease: A meta-analysis of prospective cohort studies
Creators: name: Xu, Shuxian
name: Huang, Yuli
name: Xiao, Jiping
name: Zhu, Wenjing
name: Wang, Lulu
name: Tang, Hongfeng
name: Hu, Yunzhao
name: Liu, Tiebang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Biotechnology

description: Background. Studies about work stress and the risk of coronary heart disease (CHD) have yielded inconsistent results. This meta-analysis aimed to investigate the association between job strain and the risk of CHD.Methods. We searched PubMed and Embase databases for studies reporting data on job strain and the risk of CHD. Studies were included if they reported multiple-adjusted relative risk (RR) with 95% confidence interval (CI) with respect to CHD from job strain.Results. Fourteen prospective cohort studies comprising 232,767 participants were included. The risk of CHD was increased in high-strain (RR 1.26; 95% CI 1.12–1.41) and passive jobs (RR 1.14; 95% CI 1.02–1.29) but not in active jobs (RR 1.09; 95% CI 0.97–1.22), when compared with low-strain group. The increased risk of CHD in high-strain and passive jobs was mainly driven by studies with a follow-up duration of ≥ 10 years. Neither the low-control (RR 1.06; 95% CI 0.93–1.19) nor high-demand (RR 1.13; 95% CI 0.97–1.32) dimension was independently associated with the risk of CHD.Conclusions. Individuals with high-strain and passive jobs were more likely to experience a CHD event. Intervention programs incorporating individual and organizational levels are crucial for reducing job strain and the risk of CHD.
title: Open Educational Resources: What's Your Role?
title: Presentation for Austin Public Library Staff Development Day
titleType: AlternativeTitle
Creators: name: Chapman Tripp, Hannah
name: Gits, Carrie
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Open Educational Resources
Public Libraries

description: This hour-long presentation was a part of the 2020 Staff Development Day at Austin Public Library. The creators intend this to be reused and have placed additional Creative Commons Licensing statements where we use borrowed graphics. Several of the slides contain links to a Slido audience participation element. While these Slido elements are no longer active, the authors opted to leave the slides in place allowing others to recreate and innovate upon the audience participation element. The Slido elements were created using the free version of an online tool available at https://www.sli.do/ in February 2020.
description: Librarians from Austin Community College and UT Austin will lead participants through an introduction to open educational resources (OER). Participants will learn what OER are and why teachers and students might want to use them. This session will also discuss recent legislation related to OER. Participants will be encouraged to think about how OER could be integrated into user interactions at Austin Public Library. Learning outcomes – participants will be able to: - Define Open Educational Resources: the issue, the response & your role - Define an open license - Learn how to find OER and the diversity of searching platforms - Gain an understanding of the legislative landscape surrounding OER
A human working memory advantage for social network information
Creators: name: Andrews, Jack
name: Grunewald, Karina
name: Schweizer, Susanne
Publisher: name: Zenodo
Year: 2024
Subjects: Social networks
Working memory
Depression

description: Humans are innately social. We live in large, complex, and dynamic social groups. In order to navigate these networks, we must rely on a set of social-cognitive processes, including social working memory (WM). Here, we designed a novel network memory task to study WM for social versus non-social network information across 241 participants (18-65 years) in a tightly controlled, preregistered study. We show that humans demonstrate a WM advantage for social, relative to non-social, network information. We also observed a self-relevant positivity bias, but an "other" negativity bias. These findings are interpreted in the context of an evolutionary need to belong to one's social group, to identify risks to one's social safety, and to appropriately track one's social status within a complex network of social relationships.
description: Funding provided by: Wellcome TrustROR ID: https://ror.org/029chgv08Award Number: 209127/A/17/Z
description: The dataset was collected using Prolific and was processed using R.
Study 3 Pilot Testing
Creators: name: Strange, Deryn
name: Crozier, William
Publisher: name: OSF Registries
Year: 2016

description: Pilot testing was conducted in order to develop primes that either strengthened (positive primes) or weakened (negative primes) the association between a specific form of evidence and guilt. The positive primes described a vignette of a fictional case in which the perpetrator of a crime was caught due to one form of evidence (the evidence the Ss would eventually see on the DRM list) that was accurate, reliable, and properly applied in the case. Negative primes described a case in which the form of evidence was incorrectly applied, inaccurate, and not reliable, and thus led to a wrongful conviction.

To test whether the primes were successful in increasing or decreasing the association with guilt, we measured what participants thought about the form of evidence. We did this in two ways:
1. After reading the prime, participants responded to the question "How has this story influenced your trust in _________ as evidence?" Responses were a 1-5 likert scale (1="I trust it a lot less"; 3="no change"; 5="I trust it a lot more").
2. We also asked participants to rate the "reliability" ("how prone to error") and "convincingness" ("if you were a juror, how helpful would this evidence be in determining guilt") of the relevant piece of evidence before and after reading the vignette. We used the difference in these scores as a measure of whether the vignette was successful.

Pilot testing occurred in three phases.
In phase one, participants read four of the possible eight vignettes, and answered the above questions for each form of evidence they read about. Overall, we considered this test unsuccessful in testing the primes, as many of the primes did not show significant differences between positive and negative iterations. Further, some of the effects were in the opposite direction (e.g., a positive prime resulted in less trust in the evidence). We suspect this was due to testing so many of the primes together, causing an anchoring-and-adjustment effect for some of the forms of evidence compared to others.

In phase two, we addressed the possible anchoring-and-adjustment issue by having participants read only one of the eight possible primes and rating only that form of evidence. The primes seemed to work, but were weak (small- to insignificant-effects between positive and negative primes).

In phase three, we replicated phase 2 but added additional language to the vignettes that commented on the reliability and convincingness of the evidence in the specific case. These additions proved to be successful, the primes worked for almost every measure. DNA was the evidence least affected by the primes, but this makes sense given that DNA is a largely trusted and established form of evidence - so moving its association with guilt likely takes more than the vignette we used here.

Data for all three phases are included here, as well as the relevant analyses. Further, the two iterations of the primes are included, as well as the Qualtrics surveys for phase 3.
Forced ventilated swell-shrink test for potential vertical expansive soil movement
Creators: name: Allen, John Michael
Publisher: name: The University of Texas at Austin
Year: 2005
Subjects: Soil movement
Potential vertical rise
Swell-shrink test

description: A practical method has been explored for determining the potential vertical movement in an expansive soil deposit during wetting and drying cycles. Currently, engineering practitioners are faced with using potentially inaccurate empirical methods or complicated and expensive laboratory testing combined with constitutive methods to determine expansive soil vertical movement. The proposed method is based on the use of forced ventilation to accelerate shrinkage while cyclically swelling and shrinking a soil specimen in a one-dimensional oedometer. The accelerated shrinkage reduces testing from over month to approximately 21 hours. The use of forced ventilation to induce specimen cracking was found to result in cracking similar to that observed in the field. The use of multiple swelling and shrinking cycles indicates that specimens come to equilibrium and follow the same swell-shrink path in three to four cycles. The results of the proposed method combined with seasonal moisture fluctuations allow the potential vertical movement to be estimated with a simple and practical test. The development of this test methodology improves the capability of engineers to compare laboratory work with field data
Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.
Creators: name: Bergkvist, Liza
name: Richards, Daniel R
name: Bernardo-Gancedo, Ana
name: Kumita, Janet R
name: Nilsson, Peter R
name: Brorsson, Ann-Christin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Many conflicting reports about the involvement of serum amyloid P component (SAP) in amyloid diseases have been presented over the years; SAP is known to be a universal component of amyloid aggregates but it has been suggested that it can both induce and suppress amyloid formation. By using our Drosophila model of systemic lysozyme amyloidosis, SAP has previously been shown to reduce the toxicity induced by the expression of the disease-associated lysozyme variant, F57I, in the Drosophila central nervous system. This study further investigates the involvement of SAP in modulating lysozyme toxicity using histochemistry and spectral analyses on the double transgenic WT and F57I lysozyme flies to probe; i) formation of aggregates, ii) morphological differences of the aggregated lysozyme species formed in the presence or absence of SAP, iii) location of lysozyme and iv) co-localisation of lysozyme and SAP in the fly brain. We found that SAP can counteract the toxicity (measured by the reduction in the median survival time) induced by F57I lysozyme by converting toxic F57I species into less toxic amyloid-like structures, as reflected by the spectral changes that p-FTAA undergoes when bound to lysozyme deposits in F57I-F57I-SAP flies as compared to F57I-F57I flies. Indeed, when SAP was introduced to in vitro lysozyme fibril formation, the endpoint fibrils had enhanced ThT fluorescence intensity as compared to lysozyme fibrils alone. This suggests that a general mechanism for SAP's role in amyloid diseases may be to promote the formation of stable, amyloid-like fibrils, thus decreasing the impact of toxic species formed along the aggregation pathway.
Point OutWords: protocol for a feasibility randomised controlled trial of a motor skills intervention to promote communicative development in non-verbal children with autism.
Creators: name: McKinney, Ailbhe
name: Hotson, Kathryn L
name: Rybicki, Alicia
name: Weisblatt, Emma J L
name: Días, Claudia
name: Foster, Juliet
name: Villar, Sofía S
name: Murphy, Suzanne
name: Belmonte, Matthew K
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Language
Feasibility
Communication
Motor
Autism Spectrum Disorder
Randomised Controlled Trial
Ipad
Non-verbal
Minimally Verbal

description: BACKGROUND:Point OutWords is a caregiver-delivered, iPad-assisted intervention for non-verbal or minimally verbal children with autism. It aims to develop prerequisite skills for communication such as manual and oral motor skills, sequencing, and symbolic representation. This feasibility trial aims to determine the viability of evaluating the clinical efficacy of Point OutWords. METHODOLOGY:We aim to recruit 46 non-verbal or minimally verbal children with autism and their families, approximately 23 per arm. Children in the intervention group will use Point OutWords for half an hour, five times a week, for 8 weeks. Children in the control group will have equal caregiver-led contact time with the iPad using a selection of control apps (e.g. sensory apps, drawing apps). Communication, motor, and daily living skills are assessed at baseline and post-intervention. Parents will keep diaries during the intervention period and will take part in focus groups when the intervention is completed. DISCUSSION:Point OutWords was developed in collaboration with children with autism and their caregivers, to provide an intervention for a subgroup of autism that has been historically underserved. As autism is a heterogeneous condition, it is unlikely that one style of intervention will address all aspects of its symptomatology; the motor skills approach of Point OutWords can complement other therapies that address core autistic symptoms of social cognition and communication more directly. The current feasibility trial can inform the selection of outcome measures and design for future full-scale randomised controlled trials of Point OutWords and of other early interventions in autism. TRIAL REGISTRATION:ISRCTN, ISRCTN12808402. Prospectively registered on 12 March 2019.
Consciousness & Brain Functional Complexity in Propofol Anaesthesia.
Creators: name: Varley, Thomas F
name: Luppi, Andrea I
name: Pappas, Ioannis
name: Naci, Lorina
name: Adapa, Ram
name: Owen, Adrian M
name: Menon, David K
name: Stamatakis, Emmanuel A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and topological domains, testing them on functional MRI BOLD signal data obtained from individuals undergoing various levels of sedation with the anaesthetic agent propofol, replicating our results in two separate datasets. We demonstrate that the various measures are differently able to discriminate between levels of sedation, with temporal measures showing higher sensitivity. Further, we show that all measures are strongly related to a single underlying construct explaining most of the variance, as assessed by Principal Component Analysis, which we interpret as a measure of "overall complexity" of our data. This overall complexity was also able to discriminate between levels of sedation and serum concentrations of propofol, supporting the hypothesis that consciousness is related to complexity - independent of how the latter is measured.
title: Acute rheumatic fever and rheumatic heart disease in Australia, 2016–2020
Creators: name: Australian Institute of Health and Welfare
Publisher: name: Australian Institute of Health and Welfare
Year: 2022
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are preventable diseases disproportionately affecting Aboriginal and/or Torres Strait Islander Australians living in regional and remote areas. Prevalence rates were highest in females and young people aged 5–14. These data highlight the important role of jurisdictional control programs and registers in New South Wales, Queensland, Western Australia, South Australia, and the Northern Territory.
Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives
Creators: name: Wang, Yali
name: Sun, Yang
name: Guo, Yueyan
name: Wang, Zechen
name: Huang, Ling
name: Li, Xingshu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biochemistry
Medicine
Molecular Biology
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Because of the complexity of Alzheimer's disease (AD), the multi-target-directed ligand (MTDL) strategy is expected to provide superior effects for the treatment of AD, instead of the classic one-drug-one-target strategy. In this context, we focused on the design, synthesis and evaluation of homoisoflavonoid derivatives as dual acetyl cholinesterase (AChE) and monoamine oxidase (MAO-B) inhibitors. Among all the synthesized compounds, compound 10 provided a desired balance of AChE and hMAO-B inhibition activities, with IC50 value of 3.94 and 3.44 μM, respectively. Further studies revealed that compound 10 was a mixed-type inhibitor of AChE and an irreversible inhibitor of hMAO-B, which was also confirmed by molecular modeling studies. Taken together, the data indicated that 10 was a promising dual functional agent for the treatment of AD.
Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver
Creators: name: Wang, Danfeng
name: Chen, Siyu
name: Liu, Mei
name: Liu, Chang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Early life nutritional adversity is tightly associated with the development of long-term metabolic disorders. Particularly, maternal obesity and high-fat diets cause high risk of obesity in the offspring. Those offspring are also prone to develop hyperinsulinemia, hepatic steatosis and cardiovascular diseases. However, the precise underlying mechanisms leading to these metabolic dysregulation in the offspring remain unclear. On the other hand, disruptions of diurnal circadian rhythms are known to impair metabolic homeostasis in various tissues including the heart and liver. Therefore, we investigated that whether maternal obesity perturbs the circadian expression rhythms of clock, metabolic and inflammatory genes in offspring heart and liver by using RT-qPCR and Western blotting analysis. Offspring from lean and obese dams were examined on postnatal day 17 and 35, when pups were nursed by their mothers or took food independently. On P17, genes examined in the heart either showed anti-phase oscillations (Cpt1b, Pparα, Per2) or had greater oscillation amplitudes (Bmal1, Tnf-α, Il-6). Such phase abnormalities of these genes were improved on P35, while defects in amplitudes still existed. In the liver of 17-day-old pups exposed to maternal obesity, the oscillation amplitudes of most rhythmic genes examined (except Bmal1) were strongly suppressed. On P35, the oscillations of circadian and inflammatory genes became more robust in the liver, while metabolic genes were still kept non-rhythmic. Maternal obesity also had a profound influence in the protein expression levels of examined genes in offspring heart and liver. Our observations indicate that the circadian clock undergoes nutritional programing, which may contribute to the alternations in energy metabolism associated with the development of metabolic disorders in early life and adulthood.
Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials
Creators: name: Sun, Jing
name: Buys, Nicholas
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Cell Biology

description: This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the quality of studies, a total of 15 studies with 788 subjects were selected for inclusion in the analysis. The mean difference and effect size with a 95% confidence interval (CI) were extracted from individual studies. Statistically significant pooled effects of probiotics were found on reduction of total cholesterol, low-density lipoprotein (LDL), body mass index (BMI), waist circumference, and inflammatory markers. Subgroup analysis revealed statistically significant effects of probiotics on total cholesterol and LDL when the medium was fermented milk or yogurt (P < 0.001) compared to capsule form, consumption was at least 8 weeks in duration (P < 0.001), and the probiotics consisted of multiple strains (P < 0.001) rather than a single strain. A significant reduction was found in LDL in trials which contained Lactobacillus Acidophilus strain (P < 0.001) compared to other types of strains. Our findings suggest that probiotic supplementation use is effective in lowering the lipid level and coexisting factors associated with cardiovascular disease.
Non-equilibrium Grain Boundary Wetting in Cu–Ag Alloys Containing W Nanoparticles
Creators: name: Shu, Shipeng
name: Zhang, Xuan
name: Bellon, Pascal
name: Averback, Robert S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Adding nanoparticles to soft matter and liquids is known to provide remarkable control in the processing of novel materials. Here, we demonstrate a similar potential in crystalline solids. Specifically, we show that the addition of a high density of W nanoparticles dramatically alters the coarsening behavior of precipitate-hardened Cu–Ag alloys. First, the nanoparticles suppress precipitate growth, but far more surprisingly, they induce non-equilibrium Ag wetting layers on grain boundaries. This observation is explained using kinetic Monte Carlo simulations, which show that caging of Ag precipitates by the W nanoparticles suppresses their growth and drives the formation of wetting layers.
Re-Analysis of the Original Study
Creators: name: Becker, Oliver
name: Blech, Christine
name: Van Der Meer, Carina
name: Decision Lab
Publisher: name: OSF Registries
Year: 2019

description: Re-Analysis of Cheng-Ming Jiang, Hong-Mei Sun, Long-Fei Zhu, Lei Zhao, Hong-Zhi Liu, Hong-Yue Sun (2017, JDM, Study 2)

Examination of whether and how the improvement or deterioration of choices through small additional delayed rewards or penalties impact the preference of choice of the subjects. Current research findings are reviewed.
Reserve driver scheduling
Creators: name: Gupta, Diwakar
name: Li, Fei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Transit agencies use reserve drivers to cover open work that arises from planned and unplanned time off, equipment breakdowns, weather, and special events. Work assignment decisions must be made sequentially without information about future job requests, a driver’s earlier assignment may not be interrupted to accommodate a new job (no pre-emption), and the scheduler may need to select a particular driver when multiple drivers can perform a job. Motivated by this instance of the interval scheduling problem, we propose a randomized algorithm that carries a performance guarantee relative to the best offline solution and simultaneously performs better than any deterministic algorithm. A key objective of this article is to develop an algorithm that performs well in both average and worst-case scenarios. For this reason, our approach includes discretionary parameters that allow the user to achieve a balance between a myopic approach (accept all jobs that can be scheduled) and a strategic approach (consider accepting only if jobs are longer than a certain threshold). We test our algorithm on data from a large transit agency and show that it performs well relative to the commonly used myopic approach. Although this article is motivated by a transit industry application, the approach we develop is applicable in a whole host of applications involving on-demand-processing of jobs. Supplementary materials are available for this article. Go to the publisher’s online edition of IIE Transactions for datasets, additional tables, detailed proofs, etc.
Reserve Driver Scheduling
Creators: name: Gupta, Diwakar
name: Li, Fei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Earth and Environmental Sciences

description: Transit agencies use reserve drivers to cover open work that arises from planned and unplanned time off, equipment breakdowns, weather, and special events. Work assignment decisions must be made sequentially without information about future job requests, a driver's earlier assignment may not be interrupted to accommodate a new job (no pre-emption), and the scheduler may need to select a particular driver when multiple drivers can perform a job. Motivated by this instance of the interval scheduling problem, we propose a randomized algorithm that carries a performance guarantee relative to the best offline solution and simultaneously performs better than any deterministic algorithm. A key objective of this paper is to develop an algorithm that performs well in both average and worst-case scenarios. For this reason, our approach includes discretionary parameters, which allow the user to achieve a balance between a myopic approach (accept all jobs that can be scheduled) and a strategic approach (consider accepting only if jobs are longer than a certain threshold). We test our algorithm on data from a large transit agency and show that it performs well relative to the commonly used myopic approach. Although this paper is motivated by a transit industry application, the approach we develop is applicable in a whole host of applications involving on-demand-processing of jobs.
Synthesis of π-Extended Dithienobenzodithiophene-Containing Medium Bandgap Copolymers and Their Photovoltaic Application
Creators: name: An, Lili
name: Li, Jianfeng
name: Xu, Xinghua
name: Zhang, Peng
name: Yang, Chunyan
name: Wang, Feng
name: Tong, Junfeng
name: Li, Mingjiao
name: Xia, Yangjun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Two medium bandgap alternating conjugated copolymers, namely, poly{5,10-di(2-hexyldecyloxy)dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b′]dithiophene-2,7-diyl-alt-thiophene-2,5-di-yl} (P1) and poly{5,10-di(2-hexyldecyloxy)dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b′]dithiophene-2,7-di-yl-alt-thieno[3,2-b]thiophene-2,5-diyl} (P2), were prepared by the palladium-catalyzed Stille polycondensation and characterized by gel permeation chromatography (GPC), UV-Vis absorption and photoluminescence (PL) spectra, thermal gravimetric analysis (TGA), cyclic voltammetry (CV) etc. The resultant copolymers show moderate solubility in common organic solvents and enough stabilities for photovoltaic application. And both copolymers absorb the solar light from 300–600 nm, with the optical band gaps () calculated from the onset of absorption in the solid film of ca. 2.1 eV. The highest occupied molecular orbital (HOMO) levels of two copolymers determined by CV were at about −5.35 eV. Photovoltaic propertites of the polymers were investigated by using the polymers as donor and [6,6]-phenyl-C71 butyric acid methyl ester (PC71BM) as acceptor with a weight ratio of polymer:PC71BM of 1:2. The power conversion efficiencies (PCEs) of polymer solar cells based on PDTBTT-TT reached 2.50%, with an open-circuit voltage (Voc) of 0.70 V, a short-circuit current density (Jsc) of 6.89 mA cm−2, and a fill factor (FF) of 52%, under the illumination of AM1.5, 100 mW cm−2. These results indicate that dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b′]dithiophene (DTBDT) is a promising building block for the high-performance organic electronic materials.
Analyses
Creators: name: Van Der Meer, Carina
name: Becker, Oliver
name: Blech, Christine
Publisher: name: OSF Registries
Year: 2019

description: Analysis of Cheng-Ming Jiang, Hong-Mei Sun, Long-Fei Zhu, Lei Zhao, Hong-Zhi Liu, Hong-Yue Sun (2017, JDM, Study 2)
title: Indigenous mental health, housing and homelessness
Creators: name: Australian Institute of Health and Welfare
Publisher: name: Australian Institute of Health and Welfare
Year: 2022
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description:  Evidence exists that the provision of housing and the prevention of homelessness is important for the prevention of mental ill-health and suicide among Indigenous Australians. The relationship between housing and mental health is bi-directional. A person’s mental health can be negatively affected by the lack of safe, affordable and good quality housing, and the existence of a mental illness can affect an individual’s access to suitable housing.
MPEC 2024-F81 : DAILY ORBIT UPDATE (2024 March 24)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Specific nanotoxicity of graphene oxide during zebrafish embryogenesis
Creators: name: Chen, Yuming
name: Hu, Xiangang
name: Sun, Jing
name: Zhou, Qixing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Developmental Biology

description: Graphene oxide (GO) has shown great potential for biological, medical, energy and electronic applications. As a consequence of these diverse applications, GO release into the ecosystem is inevitable; however, the corresponding risks are largely unknown, particularly with respect to the critical period of embryogenesis. This study revealed that GO adhered to and enveloped the chorion of zebrafish embryos mainly via hydroxyl group interactions, blocked the pore canals of the chorionic membrane, and caused marked hypoxia and hatching delay. Furthermore, GO spontaneously penetrated the chorion, entered the embryo via endocytosis, damaged the mitochondria and primarily translocated to the eye, heart and yolk sac regions, which are involved in the circulatory system of zebrafish. In these organs, GO induced excessive generation of reactive oxygen species and increased oxidative stress, DNA damage and apoptosis. Graphene oxide also induced developmental malformation of the eye, cardiac/yolk sac edema, tail flexure and heart rate reduction. In contrast to the common dose-effect relationships of nanoparticles, the adverse effects of GO on heart rate and tail/spinal cord flexure increased and then decreased as the GO concentration increased. These findings emphasize the specific adverse effects of GO on embryogenesis and highlight the potential ecological and health risks of GO.
2008 Organic Farm Performance in Minnesota
Creators: name: LaValla, Jack
name: LaValla, Jack
Publisher: name: Unknown
Year: 2008
Subjects: Crop Production/Industries
Farm Management

description: This report includes detailed information about the performance of organic farms and provides key measures you can use to compare your business performance against. You can reflect on and use this information when reviewing your goals. It will promote productive collaboration with family, business partners and other stakeholders as you make management decisions for your operation.
Application of Nylon6/Polypyrrole core–shell nanofibres mat as solid-phase extraction adsorbent for the determination of atrazine in environmental water samples
Creators: name: Yang, Bi-Yi
name: Qi, Fei-Fei
name: Li, Xiao-Qing
name: Liu, Jing-Jing
name: Rong, Fei
name: Xu, Qian
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Engineering
subject: Biochemistry

description: A novel solid-phase extraction (SPE) system, based on a new sorbent of Nylon6/Polypyrrole (PA6/PPy) core–shell nanofibres mat and a new packing format of SPE disks, is presented in this paper. A series of related parameters that may affect the efficiency, such as the kind of eluent and its volume, the amount of nanofibres mat, ionic strength, pH of the sample, flow rate of the sample and volume of the sample, have been investigated systematically. Under the optimised conditions, the target analyte in 10 mL water samples can be completely extracted by a 3.0 mg PA6/PPy nanofibres mat and easily eluted by 400 µL acetonitrile. Around 20 µL elution was injected directly to HPLC-UV for determination, without further concentration. Besides, the nanofibres mat could be repeatedly used up to six cycles. Satisfactory linearity was achieved in the range of 0.1–40.0 ng/mL with a correlation coefficient of 0.9999. The limit of detection (LOD) (3 S/N) was 0.03 ng/mL, which could meet the determination requirements of atrazine as per the European Union legislation, US. Safe Drinking Water Act and the State Environmental Protection Administration of China. The simple, effective and economic method was proposed for the determination of atrazine in environmental water at trace level. The recoveries ranged from 94.73 to 114.92%, with relative standard deviations (RSDs) of 2.5–4.2%, and were obtained from tap water and lake water samples with atrazine at 2.0 ng/mL, suggesting the actual feasibility of the proposed method in environmental water samples.
Mitochondrial D310 instability in Chinese lung cancer patients
Creators: name: Fang, Yu
name: Ling, Bin
name: Chen, Xian-Zhong
name: Shi, Yan-Hai
name: Cui, Jing-Hui
name: Li, Long-Yan
name: Xu, Yong-Chen
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Physics
subject: Biochemistry

description: To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients.