cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evolocumab for Early Reduction of LDL-Cholesterol Levels in Patients with Acute Coronary Syndromes (EVOPACS).
Creators: name: Koskinas, Konstantinos C
name: Windecker, Stephan
name: Pedrazzini, Giovanni
name: Mueller, Christian
name: Cook, Stéphane
name: Matter, Christian M
name: Muller, Olivier
name: Häner, Jonas
name: Gencer, Baris
name: Crljenica, Carmela
name: Amini, Poorya
name: Deckarm, Olga
name: Iglesias, Juan F
name: Räber, Lorenz
name: Heg, Dik
name: Mach, François
Publisher: name: Elsevier
Year: 2019
Subjects: 610 Medicine & health

description: BACKGROUND While guidelines recommend in-hospital initiation of high-intensity statin therapy in patients with acute coronary syndromes (ACS), low-density lipoprotein cholesterol (LDL-C) target levels are frequently not attained. Evolocumab, a rapidly acting, potent LDL-C-lowering drug, has not been studied in the acute phase of ACS. OBJECTIVES To assess the feasibility, safety, and LDL-C lowering efficacy of evolocumab initiated during the in-hospital phase of ACS. METHODS We conducted an investigator-initiated, randomized, double-blind, placebo-controlled trial involving 308 patients hospitalized for ACS with elevated LDL-C levels (≥1.8 mmol/L on high-intensity statin for at least 4 weeks; ≥2.3 mmol/L on low- or moderate-intensity statin; or ≥3.2 mmol/L on no stable dose of statin). Patients were randomly assigned 1:1 to receive subcutaneous evolocumab 420mg or matching placebo, administered in-hospital and after 4 weeks, on top of atorvastatin 40mg. The primary endpoint was percentage change in calculated LDL-C from baseline to 8 weeks. RESULTS Most patients (78.2%) had not been on previous statin treatment. Mean LDL-C levels decreased from 3.61 mmol/L to 0.79 mmol/L at week 8 in the evolocumab group, and from 3.42 mmol/L to 2.06 mmol/L in the placebo group; the difference in mean percentage change from baseline was -40.7% (95% CI: -45.2 to -36.2; p<0.001). LDL-C levels <1.8 mmol/L were achieved at week 8 by 95.7% of patients in the evolocumab group vs. 37.6% in the placebo group. Adverse events and centrally adjudicated cardiovascular events were similar in both groups. CONCLUSIONS In this first randomized trial assessing a PCSK9 antibody in the very high-risk setting of ACS, evolocumab added to high-intensity statin therapy was well tolerated and resulted in substantial reduction in LDL-C levels, rendering >95% of patients within currently recommended target levels.
Additional file 1 of Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
Creators: name: Kim, Jang-Woon
name: Kim, Juryun
name: Lee, Soon Min
name: Rim, Yeri Alice
name: Sung, Young Chul
name: Nam, Yoojun
name: Kim, Hyo-Jin
name: Kim, Hyewon
name: Jung, Se In
name: Lim, Jooyoung
name: Ju, Ji Hyeon
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 1
Halecium
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Haleciidae
Halecium

description: Halecium sp.
(fig. 4K–L, table 7)
? Halecium reflexum — Vervoort, 1968: 9, fig. 1.
not Halecium reflexum Stechow, 1919: 37, figs G–H.
Material examined. Stn. 2: 22.01.2008 —several hydrothecae, but no gonothecae, on algae; 26.01.2008 – a few hydrothecae, but no gonothecae, on rock.
Description. Colonies dwarf, stolonal, with primary hydrophores arising at more or less regular intervals from creeping hydrorhiza. Hydrophores of variable length, with conspicuous bulge basally above insertion on stolon; lateral walls smooth, gradually diverging from base towards distal end. Perisarc transparent. Hydrotheca shallow to moderately deep, margin widely flaring; a ring of desmocytes above diaphragm. Some primary hydrophores with one lateral branch, arising just below primary hydrotheca. Hydrothecae generally renovated several times; secondary hydrophores with or without basal bulge, the following ones gradually shorter and with nearly parallel sides. Hydranths large, with 18–21 tentacles; zooxanthellae absent from coenosarc. Gonothecae not seen. Nematocysts (undischarged capsules): microbasic euryteles (8.6–9.0) × (3.7–4.0) µm; microbasic mastigophores (5.4–5.8) × (1.4–1.6) µm.
Remarks. The Caribbean material assigned to H. reflexum Stechow, 1919 by Vervoort (1968) appears very similar to ours, in the following respects: the colonies are generally stolonal, with occasional small, sparingly branched stems; the primary hydrophores are provided basally with “a few undulations of the periderm”; the hydrothecae have widely flaring margins.
Halecium reflexum has so far been recorded from the Mediterranean only, and differs morphologically from the Caribbean material in the structure of the stem, which is composed of an alternation of hydrothecate and ahydrothecate segments, both with bulges at their ends. Additionally, the perisarc is undulated nearly throughout.
Halecium reflexum has been included in the synonymy of H. conicum Stechow, 1919 (replacement name for H. minutum Motz-Kossowska, 1911) by Huvé (1952). However, the gonophores of the former are not known yet, and both species seem to differ in the structure of the stem and the shape of hydrotheca, which is widely flaring in the former and only slightly in the latter.
However, neither the present material, nor that studied by Vervoort (1968) were fertile, and therefore no positive identification could be made.
Distribution. Known only from the Caribbean: St. Thomas (Vervoort 1968), Guadeloupe (present study).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on page 23, DOI: 10.5281/zenodo.184149
CODE ultra-rapid product series for the IGS
Creators: name: Dach, Rolf
name: Schaer, Stefan
name: Arnold, Daniel
name: Prange, Lars
name: Sidorov, Dmitry
name: Stebler, Pascal
name: Villiger, Arturo
name: Jäggi, Adrian
Publisher: name: Astronomical Institute, University of Bern
Year: 2018
Subjects: 520 Astronomy

description: CODE, the Center for Orbit Determination in Europe, is a joint venture of the following four institutions: Astronomical Institute, University of Bern (AIUB), Bern, Switzerland; Federal Office of Topography swisstopo, Wabern, Switzerland; Federal Agency of Cartography and Geodesy (BKG), Frankfurt a. M., Germany; Institut für Astronomische und Physikalische Geodäsie, Technische Universität München (IAPG, TUM), Munich, Germany. It acts as a global analysis center of the International GNSS Service (IGS). The operational computations are performed at AIUB using the latest development version of the Bernese GNSS Software. In this context an ultra-rapid solution series is generated considering GPS, GLONASS and Galileo satellites. It is updated several times per day and contains 24 hours of observed and 24 hours of predicted orbit interval. More details are available in: Lutz, S., G. Beutler, S. Schaer, R. Dach, A. Jäggi; 2014: CODE's new ultra-rapid orbit and ERP products for the IGS. GPS Solutions. DOI 10.1007/s10291-014-0432-2
On singular sets of H-monotone maps
Creators: name: Balogh, Zoltan
name: Penso, Valentina
Publisher: name: Heldermann Verlag
Year: 2019
Subjects: 510 Mathematics

description: The purpose of our paper is to extend a result of Alberti and Ambrosio about singularity sets of monotone multivalued maps to the sub-Riemmanian setting of Heisenberg groups. We prove that the k-th horizontal singular set of an H-monotone multivalued map of the Heisenberg group Hⁿ, with values in R²ⁿ, is (2n+1-k, H)-rectifiable.
Additional file 2 of Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
Creators: name: Kim, Jang-Woon
name: Kim, Juryun
name: Lee, Soon Min
name: Rim, Yeri Alice
name: Sung, Young Chul
name: Nam, Yoojun
name: Kim, Hyo-Jin
name: Kim, Hyewon
name: Jung, Se In
name: Lim, Jooyoung
name: Ju, Ji Hyeon
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 2
Nemalecium lighti Hargitt 1924
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Haleciidae
Nemalecium
Nemalecium lighti

description: Nemalecium lighti (Hargitt, 1924)
(fig. 4M– O)
Halecium lighti Hargitt, 1924: 489, pl. 4 fig. 13.
Nemalecium lighti — Bouillon, 1986: 73, figs 1–4, pls 1–3.— Calder, 1991d: 27, figs 17–18.— Migotto, 1996: 36, fig. 7H– I.— Gravier-Bonnet & Migotto, 2000: 207, figs 1–2.
Material examined. Stn. 1: 20.03.2008 —several colonies, ca. 5 mm high, some fertile, on Thalassia testudinum; 31.03.2008 —a few sterile stems, 4–5 mm high, on T. testudinum. Stn. 2: 22.01.2008 —a few sterile stems, up to 1 cm high, on sponge. Stn. 5: 31.03.2008 —two sterile stems, 4–5 mm high, on hydrocoral. Stn. 6: 23.03.2008 —numerous sterile colonies, with both mono- and polysiphonic stems, up to 5 cm high, on various algae, concretions and sponge; 24.03.2008 —one sterile colony, 2–4 mm high, on Caulerpa sp.; 28.03.2008 —numerous colonies, some fertile, up to 4 mm high, on T. testudinum. Stn. 7: 25.03.2008 —one fertile colony, ca. 1.8 cm high, on sponge; 27.03.2008 —a few sterile colonies, 0.4–1.0 cm high, on T. testudinum, hydrocoral and concretions.
Type locality. Port Galera Bay, Mindoro, Philippines.
Remarks. The present material is composed of both small, slender, unbranched or sparingly branched, monosiphonic stems, mainly growing on algae and phanerogams, and large, branched, polysiphonic colonies growing on hard substrates or epizoic on other organisms (mainly sponges). For a recent description of N. lighti from the western Atlantic, and additional data on it, see Calder (1991d). Gonangium development and medusoid structure were studied by Gravier-Bonnet & Migotto (2000).
Distribution. Indian Ocean, Western Pacific, Bermuda (Calder 1991d), Brazil (Migotto 1996).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on page 24, DOI: 10.5281/zenodo.184149
Risk stratification of elderly patients with acute pulmonary embolism.
Creators: name: Klingenberg, Roland
name: Schlager, Oliver
name: Limacher, Andreas
name: Méan, Marie
name: Vuilleumier, Nicolas
name: Beer, Juerg H
name: Staub, Daniel
name: Frauchiger, Beat
name: Aschwanden, Markus
name: Lämmle, Bernhard
name: Righini, Marc
name: Egloff, Michael
name: Osterwalder, Joseph
name: Angelillo, Anne
name: Kucher, Nils
name: Banyai, Martin
name: Rodondi, Nicolas
name: Von Eckardstein, Arnold
name: Aujesky, Drahomir
name: Husmann, Marc
name: Matter, Christian M
Publisher: name: Wiley-Blackwell
Year: 2019
Subjects: 610 Medicine & health
360 Social problems & social services

description: BACKGROUND Combining high-sensitivity cardiac Troponin T (hs-cTnT), NT-pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) may improve risk stratification of patients with pulmonary embolism (PE) beyond the PESI risk score. METHODS In the prospective multicenter SWITCO65+ study, we analyzed 214 patients ≥65 years with a new submassive PE. Biomarkers and clinical information for the PESI risk score were ascertained within 1 day after diagnosis. Associations of hs-TnT, NT-proBNP, hs-CRP and the PESI risk score with the primary endpoint defined as 6-month mortality were assessed. The discriminative power of the PESI risk score and its combination with hs-cTnT, NT-proBNP and hs-CRP for 6-month mortality was compared using integrated discrimination improvement (IDI) index and net reclassification improvement (NRI). RESULTS Compared with the lowest quartile, patients in the highest quartile had a higher risk of death during the first 6 months for hs-cTnT (adjusted HR 10.22; 95% CI 1.79-58.34; p=0.009), and a trend for NT-proBNP (adjusted HR 4.3; 95% CI 0.9-20.41; p=0.067) unlike hs-CRP (adjusted HR 1.97; 95% CI 0.48-8.05; p=0.344). The PESI risk score (c-statistic 0.77 (95% CI 0.69-0.84) had the highest prognostic accuracy for 6-month mortality, outperforming hs-cTnT, NT-proBNP and hs-CRP (c-statistics of 0.72, 0.72, and 0.54), respectively. Combining all three biomarkers had no clinically relevant impact on risk stratification when added to the PESI risk score (IDI = 0.067; 95% CI 0.012-0.123; p=0.018; NRI = 0.101 95% CI -0.099-0.302; p=0.321). CONCLUSIONS In elderly patients with PE, 6-month mortality can adequately be predicted by the PESI risk score alone. This article is protected by copyright. All rights reserved.
Additional file 1 of Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
Creators: name: Chai, Dafei
name: Wang, Junhao
name: Fan, Chunmei
name: Lim, Jing-Ming
name: Wang, Xu
name: Neeli, Praveen
name: Yu, Xinfang
name: Young, Ken H.
name: Li, Yong
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
WLRC Land Cover Map 2016 (Overview Map Series) Scale: 1:500,000
Creators: name: Krauer, Jürg
name: Gämperli, Ursula
name: Hurni, Kaspar
name: Fries, Matthias
name: Zeleke, Gete
name: Kassawmar, Tibebu
name: Yohannes, Aragie
Publisher: name: Centre for Development and Environment
Year: 2019
Subjects: 500 Science
550 Earth sciences & geology

description: The main methodological approach implemented to map the complex landscapes of Ethiopia at the required scales for the MapServer series was the majority and minority concept of landscape segregation that translated into the HICU-based mapping (Homogenous Image Classification Units). The employment of such an ‘exclusion-based’ approach (e.g. sub-setting of the Landsat imagery and gradually reducing the minorities/majorities) can be considered as a breakthrough in deriving important land cover information in heterogeneous landscapes, such as the rainfed agricultural area of Ethiopia. Nevertheless, the final land cover was mapped using an approach that combined the automated HICU approach with expert knowledge and visual delimination of units. This approach made it possible to distinguish cultivated land from other land use or land cover classes. Unsurprisingly, the actual amount of cultivated land is considerably larger than that indicated by official statistics in use since the mid-1980s, when the rural population was half its current size. T he team also mapped large-scale land use systems, inclusive of any foreign direct investments. Results of the study show there has been a considerable expansion and intensification of farming in the past three decades, unfortunately leading to more soil erosion.
Ethiopia Geographic Base Map: Population Distribution 2016
Creators: name: Hurni, Kaspar
name: Hodel, Elias
name: Krauer, Jürg
name: Gämperli, Ursula
name: Fries, Matthias
name: Würsch, Lukas
name: Zeleke, Gete
name: Kassawmar, Tibebu
name: Aragie, Yohannes
Publisher: name: Centre for Development and Environment
Year: 2019
Subjects: 500 Science
550 Earth sciences & geology

description: The population distribution of Ethiopia is based on a multiclass dasymetric population model taking into account popu lation/household census data and land cove/terrain data (slope) as distribution proxies. For the Somali region, only population figures at the Woreda level were available. Land cover data (WLRC) was the main dataset used for the multi-class weighting of population data in each zone. 0) Not populated: water bodies, wetland, bare land, degraded hills, river courses, swamp 1) Low population: closed and open forest, woodland, shrub and bush, riverine vegetation, Afro-alpine vegetation, savannah 2) Medium population: grassland, mining sites, large-scale investments (agriculture) 3) High population: agroforestry, cropland 4) Settlements: homestead plantation, settlements, built-up area Slope data are reclassified intopopulated (< 45 deg.) and non-popu lated (>= 45 deg.) zones. Final model verfication was done by calculating the "Zone Statistic" in ArcGIS and the deviation to the 2007 census data. The map contains various geographic feature classes (e.g. categories of roads, settlements) derived from a wide range of individu al data sources: Open Street Map data from https://osm axx.hsr.ch; terrain features (e.g. contour lines, hillshade) derived from https://www.eorc.jaxa.jp/ALOS/en/aw3d30/index.htm. Please use the scale bar for measurements on the map when resized to scales other than the original A0 pdf-format! The thematic 1:1,000,000/1:1,500,000 Overview Map Series best suits the needs of regional/ national project management and policy advice.
Intravenous antiepileptic drugs in adults with benzodiazepine-resistant convulsive status epilepticus: A systematic review and network meta-analysis.
Creators: name: Brigo, Francesco
name: Del Giovane, Cinzia
name: Nardone, Raffaele
name: Trinka, Eugen
name: Lattanzi, Simona
Publisher: name: Elsevier
Year: 2019
Subjects: 610 Medicine & health
360 Social problems & social services

description: AIM The aim of this study was to estimate the comparative efficacy and safety of antiepileptic drugs (AEDs) in adults with benzodiazepine-resistant convulsive status epilepticus (SE). METHODS MEDLINE, CENTRAL, ClinicalTrials.gov, and Opengrey.eu were searched (from inception to 3rd April, 2018) for randomized controlled trials (RCTs) of AEDs used intravenously to treat benzodiazepine-resistant SE in adults. Efficacy outcomes were SE cessation within 1 h from drug administration and seizure freedom at 24 h. Safety outcomes were respiratory depression and hypotension. Effect sizes were estimated by network meta-analyses within a frequentist framework. The hierarchy of competing interventions was established using the surface under the cumulative ranking curve (SUCRA) and mean ranks. RESULTS Five RCTs were considered, involving 349 patients. Included interventions were valproate (VPA; 20-30 mg/kg), phenytoin (PHT; 20 mg/kg), diazepam (DZP; 0.2 mg/kg, then 4 mg/h), phenobarbital (PHB; 20 mg/kg, then 100 mg every 6 h), lacosamide (LCM; 400 mg), and levetiracetam (LEV; 20 mg/kg); PHB was superior to PHT, VPA, DZP, LEV, and LCM with respect to SE cessation and performed better than VPA, DZP, and LCM in the achievement of seizure freedom at 24 h. No differences were noted between drugs in the occurrence of respiratory depression and hypotension. According to SUCRA, PHB had the greatest probabilities of being best in the achievement of SE control and seizure freedom, whereas VPA and LCM ranked best for the safety outcomes. CONCLUSIONS Our study suggests that high-dose PHB is effective in controlling SE and preventing seizure recurrence, and LCM and VPA could be better tolerated options. Further head-to-head comparative studies are strongly required to provide more definitive evidence. This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
Dynamena disticha Bosc 1802
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Sertulariidae
Dynamena
Dynamena disticha

description: Dynamena disticha (Bosc, 1802)
(fig. 5J–N)
Sertularia disticha Bosc, 1802: 101, pl. 29 fig. 2.
Dynamena disticha — Calder, 1991d: 93, fig. 50.— Migotto, 1996: 62, fig. 12A–E.— Medel & Vervoort, 1998: 25.— Peña Cantero & García Carrascosa, 2002: 121, fig. 23C–E.
Dynamena cornicina — Leloup, 1935: 39, figs 22–23.— Calder, 1983: 9, figs 1–2.—Hirohito, 1995: 167, fig. 54.
Material examined. Stn. 1: 19.01.2008 —numerous fertile colonies, 6–8 mm high, on Thalassia testudinum; 25.01.2008 —numerous fertile stems, 5–7 mm high, on T. testudinum (MHNG INVE 60980); 18.03.2008 — several fertile colonies, ca. 8 mm high, on T. testudinum; 20.03.2008 —several fertile colonies, ca. 8 mm high, on T. testudinum; 21.03.2008 —several fertile colonies, up to 8 mm high, on T. testudinum. Stn. 2: 22.01.2008 —several fertile colonies, 2–4 mm high, on sponge and algae; 26.01.2008 —a few sterile colonies, 2–4 mm high, on algae and rock. Stn. 3: 26.01.2008 —numerous sterile stems, 2–4 mm high, on algae; 01.04.2008 — numerous sterile colonies, up to 6 mm high, on concretions and algae. Stn. 4: 22.03.2008 —one sterile colony, ca. 7 mm high, on ascidian. Stn. 6: 23.03.2008 —a sterile colony, ca. 7 mm high, on Halimeda sp.; 28.03.2008 —a sterile colony, ca. 7 mm high, on T. testudinum. Stn. 7: 25.03.2008 —several sterile colonies, up to 7 mm high, on various algae, a sponge, and concretions; 27.03.2008 —one sterile colony, ca. 8 mm high, on bivalve shell.
Type locality. Atlantic Ocean, no exact locality given.
Remarks. The material originating from calm waters has long stem internodes; they are comparatively shorter in specimens from agitated waters.
The gonothecae of D. disticha have been described either occurring on the stolon (Calder 1991d) or arising from lower stem internodes (Medel & Vervoort 1998), or both (Hirohito 1995). In the present specimens, the gonothecae are mainly borne on the stolon but, in some stems, peculiar gonothecae arise from the hydrothecal openings. These gonothecae did not retain any specific feature of the common type: they are sac-shaped, of variable length and width, with smooth to slightly undulated walls, but not ridges; the apical end is rounded and no aperture could be observed (see fig. 5M–N). The gonothecal content is a homogenous mass of tissue (male gonothecae?).
Distribution. Circumglobal in tropical, subtropical and temperate waters (Peña Cantero & García Carrascosa 2002). The Caribbean records are summarized by Calder & Kirkendale (2005).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on pages 30-31, DOI: 10.5281/zenodo.184149
Normative data for multiple breath washout outcomes in school-aged Caucasian children.
Creators: name: Anagnostopoulou, Pinelopi
name: Latzin, Philipp
name: Jensen, Renee
name: Stahl, Mirjam
name: Harper, Alana
name: Yammine, Sophie
name: Usemann, Jakob
name: Foong, Rachel E
name: Spycher, Ben
name: Hall, Graham L
name: Singer, Florian
name: Stanojevic, Sanja
name: Mall, Marcus
name: Ratjen, Felix
name: Ramsey, Kathryn A
Publisher: name: European Respiratory Society
Year: 2020
Subjects: 610 Medicine & health
360 Social problems & social services

description: BACKGROUND The nitrogen multiple breath washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. The aim of this study was to generate reference values for N2MBW outcomes in a cohort of healthy Caucasian school-aged children. METHODS N2MBW data from healthy Caucasian school-age children between 6 and 18 years were collected from four experienced centers. Measurements were performed using an ultrasonic flowmeter (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) and were analyzed with commercial software (Spiroware, 3.2.1, Eco Medics AG). Normative values and upper limits of normal were generated for lung clearance index at 2.5% (LCI2.5%) and at 5% (LCI5%), moment ratios (M1/M0 and M2/M0), and a prediction equation generated for functional residual capacity (FRC). RESULTS Four hundred and eighty five trials from 180 healthy Caucasian children aged from 6 to 18 years were used for analysis. While LCI increased with age, this increase was negligible (0.04 units/year for LCI2.5%) and therefore fixed upper limits of normal were defined for this age group. These limits were 7.91 for LCI2.5%, 5.73 for LCI5%, 1.75 for M1/M0, and 6.15 for M2/M0 respectively. Height and weight were found to be independent predictors of FRC. CONCLUSION We report reference values for N2MBW outcomes measured on a commercially available ultrasonic flowmeter device (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) in healthy school-aged children to allow accurate interpretation of ventilation distribution outcomes and FRC in children with lung disease.
Additional file 2 of Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
Creators: name: Chai, Dafei
name: Wang, Junhao
name: Fan, Chunmei
name: Lim, Jing-Ming
name: Wang, Xu
name: Neeli, Praveen
name: Yu, Xinfang
name: Young, Ken H.
name: Li, Yong
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 2
Ring-shear test data of quartz sand from the Tectonic Modelling Lab of the University of Bern (CH)
Creators: name: Zwaan, Frank
name: Schreurs, Guido
name: Gentzmann, Robert
name: Warsitzka, Michael
name: Rosenau, Matthias
Publisher: name: GFZ Data Services
Year: 2018
Subjects: 550 Earth sciences & geology

description: This dataset provides internal and basal (wall) friction data from ring-shear tests (RST) on a quartz sand material that has been used in tectonic experiments in Zwaan et al. (2016, 2017), Zwaan and Scheurs (2017) and in the Tectonic Modelling Lab of the University of Bern (CH) as an analogue for brittle layers in the crust or lithosphere. The material has been characterized by means of internal and basal friction coefficients μ and cohesions C as a remote service by the Helmholtz Laboratory for Tectonic Modelling (HelTec) at the GFZ German Research Centre for Geosciences in Potsdam for the Tectonic Modelling Lab of the University of Bern (UB). According to our analysis the material behaves as a Mohr-Coulomb material characterized by a linear failure envelope. Internal peak, dynamic and reactivation friction coefficients are μP = 0.73, μD = 0.61, and μR = 0.66, respectively. Internal cohesions C are in the range of 10 to 70 Pa. Basal peak, dynamic and reactivation friction coefficients are μP = 0.41, μD = 0.35, and μR = 0.36, respectively, whereas basal cohesions C are in the range of 120 to 150 Pa. The rate dependency of the internal dynamic friction coefficient is insignificant (<1%).
Ethiopia - Travel Time to Regional Centres (Overview Map Series) Scales: 1:1,000,000/1:1,500,000
Creators: name: Hurni, Kaspar
name: Hodel, Elias
name: Krauer, Jürg
name: Gaemperli, Ulla
Publisher: name: Centre for Development and Environment
Year: 2019
Subjects: 550 Earth sciences & geology

description: The accessibility indicated as "travel time" is calculated using the cost-distance function of ArcGIS by defining source features (e.g. regional centres from where the travel time is calculated) and a cost raster (each pixel indicates the amount of time needed to cross it). To calculate the cost raster, the model includes land cover (W LRC) to define the travel speed off-road, roads infrastructure, terrain that reduces the travel speed with increasing slope, rivers, and water-bodies. We essentially include all the available spatial data of a given extent that can in some way impact peoples travel speed. This includes things that can make us travel faster (e.g. roads), but also things that serve as brakes (e.g. slopes, water bodies) or even barriers (e.g. borders). When preparing the cost raster one must also consider what means of transportation are available to the people represent in the accessibility map. It is generally assumed that people use the fastest means of transportation available. This means travelling by car or bus on roads, or by foot when travelling off-road.
Additional file 1 of Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Creators: name: Ackermann, Mania
name: Saleh, Fawaz
name: Abdin, Shifaa M.
name: Rafiei Hashtchin, Anna
name: Gensch, Ingrid
name: Golgath, Julia
name: Carvalho Oliveira, Marco
name: Nguyen, Ariane H. H.
name: Gaedcke, Svenja
name: Fenske, Arno
name: Jang, Mi-Sun
name: Jirmo, Adan C.
name: Abeln, Markus
name: Hansen, Gesine
name: Lachmann, Nico
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Additional file 1: Fig. S1. Organoid-based production of iPSC-Mac in intermediate scale bioreactors recapitulates embryonic hematopoietic development. A Analysis of KDR/VEGFR and CD45/PPTRC at different stages of differentiation as well as in iPSC-derived macrophages (iPSC-Mac) by qRT-PCR. Values are represented as relative RNA expression to GAPDH (housekeeping gene) (individual values with mean ± SD, iPSC line#1: blue square, and iPSC line#2: purple dots, n = 2–3 per line, n.d. indicates detection limit of the target gene) B and C Flow cytometric analysis of CD34, CD144, CD43 and CD45 expression during early hematopoietic differentiation. Hemanoids were dissociated and analyzed on day 4, 7 and 10 of mesoderm priming as well as during hematopoietic differentiation after they initiated production of iPSC-derived Mac. B Representative FACs plots CD34+/CD144+/CD45− Hemato-endothelial progenitors, CD34+/CD144-/CD43+ early hematopoietic progenitors and CD34+/CD144-/CD45+ hematopoetic progenitors during mesoderm priming and early hematopoietic differentiation (representative data shown for iPSC line#1). C Representative gating strategy: Populations were pre-gated for viable cells (FSC/SSC), single cells (FSC-A/FSC-H), CD34+ cells (CD34-FITC/autofluorescence), viability staining (Zombie-Aqua/PB450-A). D Immunohistochemical analysis of VE-Cadherin/CD144, VEGFR2 and CD45 expression in hemanoids derived from day 4, 7 and 10 of mesoderm priming as well as from hemanoids during hematopoietic differentiation after they initiated production of iPSC-derived Mac (day 7–10). Arrows indicate characteristic regions (scale bar = 200 µm, data shown for iPSC line#2, representative of n = 2).
A comparison between the two lobes of comet 67P / Churyumov-Gerasimenko based on D/H ratios in H₂O measured with the Rosetta / ROSINA DFMS
Creators: name: Isaac R.H.G., Schroeder I
name: Altwegg, Kathrin
name: Balsiger, Hans
name: Berthelier, Jean-Jacques
name: Combi, Michael
name: De Keyser, Johan
name: Fiethe, Björn
name: Fuselier, Stephen
name: Gombosi, Tamas
name: Hansen, Kenneth
name: Rubin, Martin
name: Shou, Yinsi
name: Tenishev, Valeriy
name: Sémon, Thierry
name: Wampfler, Susanne
name: Wurz, Peter
Publisher: name: Oxford University Press
Year: 2019
Subjects: 520 Astronomy
530 Physics

description: The nucleus of the Jupiter-family comet 67P / Churyumov-Gerasimenko was discovered to be bi-lobate in shape when the European Space Agency spacecraft Rosetta first approached it in July 2014. The bi-lobate structure of the cometary nucleus has led to much discussion regarding the possible manner of its formation and on how the composition of each lobe might compare with that of the other. During its two-year-long mission from 2014 to 2016, Rosetta remained in close proximity to 67P / Churyumov-Gerasimenko, studying its coma and nucleus in situ. Based on lobe-specific measurements of HDO and H₂O performed with the ROSINA DFMS mass spectrometer on board Rosetta, the Deuterium-to-Hydrogen ratios in water from the two lobes could be compared. No appreciable difference was observed, suggesting that both lobes formed in the same region and are homogeneous in their Deuterium-to-Hydrogen ratios.
Sertularia loculosa Busk 1852
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Sertulariidae
Sertularia
Sertularia loculosa

description: Sertularia loculosa Busk, 1852
(fig. 6F–G)
Sertularia loculosa Busk, 1852: 393, pl. 19 fig. 9.— Migotto, 1996: 71, fig. 13F–I.— Schuchert, 2003: 188, fig. 42. Sertularia ligulata Thornely, 1904: 116, pl. 2 fig. 1–1B.— Vervoort, 1959: 277, fig. 37.— Millard & Bouillon, 1973: 74, fig. 9G.—Hirohito, 1974: 22, fig. 9.—Millard, 1975: 307, fig. 100A, D.— Vervoort & Vasseur, 1977: 53, fig. 24.— Gibbons & Ryland, 1989: 420, fig. 36.—Hirohito, 1995: 213, fig. 71A–G.
Material examined. Stn. 7: 25.03.2008 —several colonies, up to 5 mm high, some fertile, on Dictyota sp. and other algae; 27.03.2008 — a dense, sterile colony, ca. 6 mm high, on Halimeda sp.
Type locality. Bass Strait, Australia.
Remarks. This species is easily recognizable due to the presence of an adcauline ligula, which is much larger compared to the tentacles of the hydranth. For a recent description and additional comments, see Migotto (1996).
Distribution. Widely distributed over the tropical and subtropical Indian and Pacific Oceans; also reported from the eastern Atlantic (Vervoort & Vasseur 1977).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on page 35, DOI: 10.5281/zenodo.184149
iscogen: Stata module to translate ISCO codes
Creators: name: Jann, Ben
Publisher: name: Boston College Department of Economics
Year: 2019
Subjects: 300 Social sciences, sociology & anthropology

description: iscogen is a tool to translate ISCO codes (International Standard Classification of Occupations). Various transformations such as recoding between ISCO-08, ISCO-88, and ISCO-68 or generating prestige scores and occupational classes are supported. A command to label ISCO codes is also provided.
Additional file 2 of Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Creators: name: Ackermann, Mania
name: Saleh, Fawaz
name: Abdin, Shifaa M.
name: Rafiei Hashtchin, Anna
name: Gensch, Ingrid
name: Golgath, Julia
name: Carvalho Oliveira, Marco
name: Nguyen, Ariane H. H.
name: Gaedcke, Svenja
name: Fenske, Arno
name: Jang, Mi-Sun
name: Jirmo, Adan C.
name: Abeln, Markus
name: Hansen, Gesine
name: Lachmann, Nico
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Additional file 2: Fig. S2. Phenotypic characterization of iPSC-derived macrophages continuously produced in intermediate scale bioreactors (I). A Representative brightfield images and cytospin staining for iPSC-derived macrophages (iPSC-Mac) derived from harvest 1b, 3 and 5 for iPSC line#2 (left) and iPSC line#3 (right), respectively. B Representative gating strategy for flow cytometric analysis of iPSC-Mac. Populations were pre-gated for viable cells (FSC7SSC) and single cells (SSC-A/SSC-H). C Frequencies of CD11b, CD14, CD163, CD86, CD206, and HLA-DR expression on iPSC-Mac from all three iPSC lines and all different harvests (Individual values with mean).
Additional file 3 of Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Creators: name: Ackermann, Mania
name: Saleh, Fawaz
name: Abdin, Shifaa M.
name: Rafiei Hashtchin, Anna
name: Gensch, Ingrid
name: Golgath, Julia
name: Carvalho Oliveira, Marco
name: Nguyen, Ariane H. H.
name: Gaedcke, Svenja
name: Fenske, Arno
name: Jang, Mi-Sun
name: Jirmo, Adan C.
name: Abeln, Markus
name: Hansen, Gesine
name: Lachmann, Nico
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Additional file 3: Fig. S3. Phenotypic characterization of iPSC-derived macrophages continuously produced in intermediate scale bioreactors (II). A Representative brightfield images and cytospin staining for iPSC-derived macrophages (iPSC-Mac) derived from the three different lines. B Gating strategy and flow cytometric analysis of CD11b, CD14, CD163, CD86, HLA-DR and CD206 expression on primary monocyte-derived macrophages (MDM, representative data of n = 5). C Frequency of CD86, CD206 and HLA-DR positive cells derived from different harvests/differentiations of the three different hiPSC lines as well as primary monocyte-derived macrophages. Individual values with mean ± SD, n = 5–15). Coefficient of variation (CV) is given for all values.
The Relationship between Educational Pathways and Occupational Outcomes at the Intersection of Gender and Social Origin
Creators: name: Zimmermann, Barbara
name: Seiler, Simon
Publisher: name: Cogitatio Press
Year: 2019
Subjects: 300 Social sciences, sociology & anthropology

description: In this article, we are interested in the differences in the educational pathways and subsequent labour market outcomes by social origin and gender. We apply sequence analyses to model the educational trajectories and conduct regression analyses to determine how the individual’s own social status and the salary at labour market entry differs. First, our results show that educational pathways vary by parental status and gender when controlling for reading and mathematics/science skills. Men and pupils with a lower socioeconomic background are overrepresented in vocational education, whereas women and pupils with a more privileged socioeconomic background more often pursue general and academic tracks. Second, these different trajectories lead to unequal occupational status and income. Besides these indirect effects, significant direct effects of parental status and gender on the individual’s own occupational status and salary can be found. Together, these findings provide a broad overview of the emergence of inequalities by gender and social origin over the early life course, ranging from differences in skills learned in school to labour market outcomes.
Antiepileptic drug monotherapy for epilepsy in the elderly: A systematic review and network meta-analysis.
Creators: name: Lattanzi, Simona
name: Trinka, Eugen
name: Del Giovane, Cinzia
name: Nardone, Raffaele
name: Silvestrini, Mauro
name: Brigo, Francesco
Publisher: name: Wiley-Blackwell
Year: 2019
Subjects: 610 Medicine & health
360 Social problems & social services

description: OBJECTIVE To estimate the comparative efficacy and safety of antiepileptic drugs (AEDs) in the elderly with new-onset epilepsy. METHODS We searched electronic databases for randomized controlled trials (RCTs) of monotherapy AEDs to treat epilepsy in elderly. The following outcomes were analyzed: seizure freedom and withdrawal from the study for any cause at 6 and 12 months; withdrawal from the study for any adverse event (AE) at 12 months; and occurrence of any AE at 12 months. Effect sizes were estimated by network meta-analyses within a frequentist framework. The hierarchy of competing interventions was established using the surface under the cumulative ranking curve (SUCRA) and mean ranks. RESULTS Five RCTs (1425 patients) were included. Included AEDs were carbamazepine immediate- and controlled-release (CBZ-IR, CBZ-CR), gabapentin (GBP), lacosamide (LCM), lamotrigine (LTG), levetiracetam (LEV), phenytoin (PHT), and valproic acid (VPA). At the pairwise and network meta-analyses, there were no differences in any of the comparison according to 6- and 12-month seizure freedom. The treatment with CBZ-IR and CBZ-CR was associated with a higher risk of withdrawal than LTG, LEV, or VPA, and CBZ-IR had the overall highest probability of discontinuation across all AEDs. According to SUCRA, the following had the greatest likelihood ranking best for seizure freedom at 6 and 12 months: LCM, LTG, and LEV. CBZ-CR and CBZ-IR had the highest probabilities of being worst for the 12-month retention. CBZ-IR, CBZ-CR, and GBP had the highest probabilities of withdrawal from the study for AEs, , and VPA had the highest probability of being the best-tolerated option. SIGNIFICANCE Although no significant difference in efficacy was found across treatments, LCM, LTG, and LEV had the highest probability of ranking best for achieving seizure freedom. CBZ-IR and CBZ-CR showed a poor tolerability profile, leading to higher withdrawal rates compared to LEV and VPA.
Sertularia marginata Kirchenpauer 1864
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Sertulariidae
Sertularia
Sertularia marginata

description: Sertularia marginata Kirchenpauer, 1864
(fig. 6H–I)
Sertularia marginata Kirchenpaur, 1864: 13, fig. 8A–C.— Van Gemerden-Hoogeveen, 1965: 39, figs 13–17.—Millard, 1975: 311, fig. 99A–D.— Calder, 1983: 15, figs 6–7.— Migotto, 1996: 73, fig. 14A–C.— Medel & Vervoort, 1998: 66, figs 20C, 22.—Migotto, 1998: 1, figs 1–2.— Vervoort & Watson, 2003: 185, fig. 43D–G.
Tridentata marginata — Calder, 1991d: 107, figs 56–57.
Desmoscyphus inflatus Versluys, 1899: 42, figs 11–13.
Sertularia inflata — Vervoort, 1959: 281, figs 39–41.— Van Gemerden-Hoogeveen, 1965: 45, figs 18–22.— Vervoort, 1968: 48, figs 23–24.
Sertularia versluysi Nutting, 1904: 53, pl. 1 figs 4–9.
Material examined. Stn. 7: 25.03.2008 —numerous colonies, up to 1.8 cm high, some fertile, on rock, ascidians, and various algae.
Type locality. Pacific Ocean, no exact locality given.
Remarks. For recent descriptions of S. marginata, see Calder (1991d) and Medel & Vervoort (1998). The life cycle of this medusoid-producing sertulariid was studied in detail by Migotto (1998).
Distribution. Circumglobal in tropical and subtropical seas (Medel & Vervoort 1998). The Caribbean records are summarized by Calder & Kirkendale (2005).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on page 35, DOI: 10.5281/zenodo.184149
Catalyzing Transformations to Sustainability in the World's Mountains
Creators: name: Klein, J. A.
name: Tucker, C. M.
name: Nolin, A. W.
name: Hopping, K. A.
name: Reid, R. S.
name: Steger, C.
name: Grêt‐Regamey, A.
name: Lavorel, S.
name: Müller, B.
name: Yeh, E. T.
name: Boone, R. B.
name: Bourgeron, P.
name: Butsic, V.
name: Castellanos, E.
name: Chen, X.
name: Dong, S. K.
name: Greenwood, G.
name: Keiler, Margreth
name: Marchant, R.
name: Seidl, R.
name: Spies, T.
name: Thorn, J.
name: Yager, K.
Publisher: name: Wiley
Year: 2019
Subjects: 910 Geography & travel

description: Mountain social‐ecological systems (MtSES) are vital to humanity, providing ecosystem services to over half the planet's human population. Despite their importance, there has been no global assessment of threats to MtSES, even as they face unprecedented challenges to their sustainability. With survey data from 57 MtSES sites worldwide, we test a conceptual model of the types and scales of stressors and ecosystem services in MtSES and explore their distinct configurations according to their primary economic orientation and land use. We find that MtSES worldwide are experiencing both gradual and abrupt climatic, economic, and governance changes, with policies made by outsiders as the most ubiquitous challenge. Mountains that support primarily subsistence‐oriented livelihoods, especially agropastoral systems, deliver abundant services but are also most at risk. Moreover, transitions from subsistence‐ to market‐oriented economies are often accompanied by increased physical connectedness, reduced diversity of cross‐scale ecosystem services, lowered importance of local knowledge, and shifting vulnerabilities to threats. Addressing the complex challenges facing MtSES and catalyzing transformations to MtSES sustainability will require cross‐scale partnerships among researchers, stakeholders, and decision makers to jointly identify desired futures and adaptation pathways, assess trade‐offs in prioritizing ecosystem services, and share best practices for sustainability. These transdisciplinary approaches will allow local stakeholders, researchers, and practitioners to jointly address MtSES knowledge gaps while simultaneously focusing on critical issues of poverty and food security.
Sertularia notabilis Fraser 1947
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Sertulariidae
Sertularia
Sertularia notabilis

description: Sertularia notabilis Fraser, 1947
(fig. 6J–K)
Sertularia notabilis Fraser, 1947: 11, pl. 2 fig. 5.— Migotto & Vervoort, 1998: 89, figs 1–14.
Material examined. Stn. 7: 25.03.2008 —two small, sterile colonies, ca. 2 mm high, on algae.
Type locality. Tortuga Island, Haiti.
Remarks. Though sterile, the present material is readily recognizable due to the characteristic shape of the hydrothecae, the presence of 3 internal projections of perisarc (one abcauline and 2 latero-adcauline) just below the hydrothecal aperture, and the transverse nodes of the stem. For a recent, thorough redescription of this species, see Migotto & Vervoort (1998).
Distribution. Scattered records from the tropical western Atlantic: Caribbean (Fraser 1947, present study), Brazil (Migotto & Vervoort 1998).
description: Published as part of Galea, Horia R., 2008, On a collection of shallow-water hydroids (Cnidaria: Hydrozoa) from Guadeloupe and Les Saintes, French Lesser Antilles, pp. 1-54 in Zootaxa 1878 on pages 35-36, DOI: 10.5281/zenodo.184149
Additional file 4 of Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Creators: name: Ackermann, Mania
name: Saleh, Fawaz
name: Abdin, Shifaa M.
name: Rafiei Hashtchin, Anna
name: Gensch, Ingrid
name: Golgath, Julia
name: Carvalho Oliveira, Marco
name: Nguyen, Ariane H. H.
name: Gaedcke, Svenja
name: Fenske, Arno
name: Jang, Mi-Sun
name: Jirmo, Adan C.
name: Abeln, Markus
name: Hansen, Gesine
name: Lachmann, Nico
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Additional file 4: Fig. S4. Heat map of yolk sac macrophages genes. A heat map illustrating a list of genes associated with primitive yolk-sac macrophages (adapted from [36]).