cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Herschel Survey of the Palomar-Green QSOs at Low Redshift
Creators: name: Petric, Andreea O.
name: Ho, Luis C.
name: Flagey, Nicolas J. M.
name: Scoville, Nicholas Z.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the global cold dust properties of 85 nearby (z < 0.5) QSOs, chosen from the Palomar-Green sample of optically luminous quasars. We determine their infrared spectral energy distributions and estimate their rest-frame luminosities by combining Herschel data from 70 to 500 microns with near-infrared and mid-infrared measurements from the Two Micron All Sky Survey (2MASS) and the Wide-Field Infrared Survey Explorer (WISE). In most sources the far-infrared (FIR) emission can be attributed to thermally heated dust. Single temperature modified black body fits to the FIR photometry give an average dust temperature for the sample of 33~K, with a standard deviation of 8~K, and an average dust mass of 7E6 Solar Masses with a standard deviation of 9E6 Solar Masses. Estimates of star-formation that are based on the FIR continuum emission correlate with those based on the 11.3 microns PAH feature, however, the star-formation rates estimated from the FIR continuum are higher than those estimated from the 11.3 microns PAH emission. We attribute this result to a variety of factors including the possible destruction of the PAHs and that, in some sources, a fraction of the FIR originates from dust heated by the active galactic nucleus and by old stars.
description: accepted for publication in ApJS
(400154) Philip Meldrum Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease
Creators: name: Kawaguchi, A.
name: Mailman, R. B.
name: Lee, S.
name: Huang, X.
name: Truong, Y.
name: Sen, S.
name: Lewis, M. M.
name: Du, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Parkinson's disease (PD) presents clinically with varying degrees of resting tremor, rigidity, and bradykinesia. For decades, striatal-thalamo-cortical (STC) dysfunction has been implied in bradykinesia and rigidity, but does not explain resting tremor in PD. To understand the roles of cerebello-thalamo-cortical (CTC) and STC circuits in the pathophysiology of the heterogeneous clinical presentation of PD, we collected functional magnetic resonance imaging (fMRI) data from 17 right-handed PD patients [nine tremor predominant (PDT) and eight akinetic-rigidity predominant (PDAR)] and 14 right-handed Controls while they performed internally-guided (IG) sequential finger tapping tasks. The percentage of voxels activated in regions constituting the STC and CTC [divided as cerebellar hemisphere-thalamo-cortical (CHTC) and vermis-thalamo-cortical (CVTC)] circuits was calculated. Multivariate analysis of variance compared the activation patterns of these circuits between study groups. Compared to Controls, both PDAR and PDT subjects displayed an overall increase in the percentage of voxels activated in both STC and CTC circuits. These increases reached statistical significance in contralateral STC and CTC circuits for PDT subjects, and in contralateral CTC pathways for PDAR subjects. Comparison of PDAR and PDT subjects revealed significant differences in ipsilateral STC (p=0.005) and CTC (p=0.043 for CHTC and p=0.003 for CVTC) circuits. These data support the differential involvement of STC and CTC circuits in PD subtypes, and help explain the heterogeneous presentation of PD symptoms. These findings underscore the importance of integrating CTC circuits in understanding PD and other disorders of the basal ganglia.
(400149) Eliza Russell Meldrum
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Coherent controlization using superconducting qubits
Creators: name: Friis, Nicolai
name: Melnikov, Alexey A.
name: Kirchmair, Gerhard
name: Briegel, Hans J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Coherent controlization, i.e., coherent conditioning of arbitrary single- or multi-qubit operations on the state of one or more control qubits, is an important ingredient for the flexible implementation of many algorithms in quantum computation. This is of particular significance when certain subroutines are changing over time or when they are frequently modified, such as in decision-making algorithms for learning agents. We propose a scheme to realize coherent controlization for any number of superconducting qubits coupled to a microwave resonator. For two and three qubits, we present an explicit construction that is of high relevance for quantum learning agents. We demonstrate the feasibility of our proposal, taking into account loss, dephasing, and the cavity self-Kerr effect.
description: 11+7 pages, many figures
Fast dopamine release events in the nucleus accumbens of early adolescent rats
Creators: name: Smith, K. J.
name: Zitzman, D. L.
name: Robinson, D. L.
name: Spear, L. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Subsecond fluctuations in dopamine (dopamine transients) in the nucleus accumbens are often time-locked to rewards and cues and provide an important learning signal during reward processing. As the mesolimbic dopamine system undergoes dynamic changes during adolescence in the rat, it is possible that dopamine transients encode reward and stimulus presentations differently in adolescents. However, to date no measurements of dopamine transients in awake adolescents have been made. Thus, we used fast scan cyclic voltammetry to measure dopamine transients in the nucleus accumbens core of male rats (29 – 30 days of age) at baseline and with the presentation of various stimuli that have been shown to trigger dopamine release in adult rats. We found that dopamine transients were detectable in adolescent rats and occurred at a baseline rate similar to adult rats (71 – 72 days of age). However, unlike adults, adolescent rats did not reliably exhibit dopamine transients at the unexpected presentation of visual, audible and odorous stimuli. In contrast, brief interaction with another rat increased dopamine transients in both adolescent and adult rats. While this effect habituated in adults at a second interaction, it persisted in the adolescents. These data are the first demonstration of dopamine transients in adolescent rats and reveal an important divergence from adults in the occurrence of these transients that may result in differential learning about rewards.
(400150) Edgar Leslie Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MOBILIDADE URBANA EM JAPERI/RJ: ÊNFASE NAS POLÍTICAS PÚBLICAS EM TRANSPORTES
Creators: name: De Brito Lucindo Da Silva, Otavio Alves
Publisher: name: Zenodo
Year: 2022
Subjects: Humanidades Digitais
SIAC UFRJ
11ª SIAC
Mobilidade Japeri
Japeri/RJ
Mobilidade das Cidades da Baixada Fluminense

description: Apresentação no 11ª SIAC da UFRJ.
MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern
Creators: name: Wu, D.
name: Hammond, S.
name: Pak, E.
name: Murashov, A. K.
name: Raafat, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Recently, functional and potent RNA interference (RNAi) has been reported in peripheral nerve axons transfected with short-interfering RNA (siRNA). In addition, components of RNA-induced silencing complex (RISC) have been identified in axotomized sciatic nerve fibers as well as in regenerating dorsal root ganglia (DRG) neurons in vitro. Based on these observations, and on the fact that siRNA and microRNAs (miRNA) share the same effector enzymes, we hypothesized that the endogenous miRNA biosynthetic pathway would respond to peripheral nerve injury. To answer this question, we investigated changes in the expression of miRNA biosynthetic enzymes following peripheral nerve crush injury in mice. Here we show that several pivotal miRNA biosynthetic enzymes are expressed in an injury-regulated pattern in sciatic nerve in vivo, and in DRG axons in vitro. Moreover, the sciatic nerve lesion induced expression of mRNA-processing bodies (P-bodies), which are the local foci of mRNA degradation in DRG axons. In addition, a group of injury-regulated miRNAs was identified by miRNA microarray and validated by qPCR and in situ hybridization analyses. Taken together, our data support the hypothesis that the peripheral nerve regeneration processes may be regulated by miRNA pathway.
(400146) George Grant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Führen Mischungen mehrerer Süßungsmittel zu gesundheitlichen Risiken für den Menschen?: Stellungnahme Nr. 005/2023 des BfR vom 07. Februar 2023
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2023
Subjects: subject: 000

description: BfR-Stellungnahmen, vol. 2023, no. 005
(400147) George C L Grant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology
Creators: name: Liu, W.
name: Wills, D. N.
name: Crews, F. T.
name: Ehlers, C. L.
name: Criado, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Substance abuse typically begins in adolescence; therefore, the impact of alcohol during this critical time in brain development is of particular importance. Epidemiological data indicate that excessive alcohol consumption is prevalent among adolescents and may have lasting neurobehavioral consequences. Loss of cholinergic input to the forebrain has been demonstrated following fetal alcohol exposure and in adults with Wernicke-Korsakoff syndrome. In the present study, immunohistochemistry for choline acetyltransferase (ChAT) was determined to assess forebrain cholinergic neurons (Ch1–4), and behavioral changes following periadolescent alcohol exposure. Wistar rats were exposed to intermittent ethanol vapor (14 hrs on/10 hrs off/day) for 35 days from PD 22-PD 57 (average blood alcohol concentration (BAC): 163 mg%). Rats were withdrawn from vapor and assessed for locomotor activity, startle response, conflict behavior in the open field, and immobility in the forced swim test, as adults. Rats were then sacrificed at day 71/72 and perfused for histochemical analyses. Ethanol vapor exposed rats displayed: increased locomotor activity 8 hrs after the termination of vapor delivery for that 24 hr period at day 10 and day 20 of alcohol vapor exposure, significant reductions in the amplitude of their responses to prepulse stimuli during the startle paradigm at 24 hrs withdrawal, and at two weeks following withdrawal, less anxiety-like and/or more “disinhibitory” behavior in the open field conflict, and more immobility in the forced swim test. Quantitative analyses of ChAT immunoreactivity revealed a significant reduction in cell counts in the Ch1–2 and Ch3–4 regions of the basal forebrain in ethanol vapor exposed rats. This reduction in cell counts was significantly correlated with less anxiety-like and/or more “disinhibitory” behavior in the open field conflict test. These studies demonstrate that behavioral measures of arousal, affective state, disinhibitory behavior and ChAT+IR, are all significantly impacted by periadolescent ethanol exposure and withdrawal in Wistar rats.
Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex
Creators: name: Vetreno, R. P.
name: Crews, F. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Adolescence is a critical developmental stage of life during which the prefrontal cortex (PFC) matures, and binge drinking and alcohol abuse are common. Recent studies have found that ethanol increases neuroinflammation via upregulated high-mobility group box 1 (HMGB1) signaling through Toll-like receptors (TLRs). HMGB1/TLR ‘danger signaling’ induces multiple brain innate immune genes that could alter brain function. To determine whether adolescent binge drinking persistently increases innate immune gene expression in the PFC, rats (P25–P55) were exposed to adolescent intermittent ethanol (AIE [5.0 g/kg, 2-day on/2-day off schedule]). On P56, HMGB1/TLR danger signaling was assessed using immunohistochemistry (i.e., +immunoreactivity [+IR]). In a separate group of subjects, spatial and reversal learning on the Barnes maze was assessed in early adulthood (P64–P75), and HMGB1/TLR danger signaling was measured using immunohistochemistry for +IR and RT-PCR for mRNA in adulthood (P80). Immunohistochemical assessment at P56 and 24 days later at P80 revealed increased frontal cortical HMGB1, TLR4, and TLR3 in the AIE-treated rats. Adolescent intermittent ethanol treatment did not alter adult spatial learning on the Barnes maze, but did cause reversal learning deficits and increased perseverative behavior. Barnes maze deficits correlated with the expression of danger signal receptors in the PFC. Taken together, these findings provide evidence that adolescent binge drinking leads to persistent upregulation of innate immune danger signaling in the adult PFC that correlates with adult neurocognitive dysfunction.
Reliability study of a coherent system with single general standby component
Creators: name: Kundu, Pradip
name: Hazra, Nil Kamal
name: Nanda, Asok K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The properties of a coherent system with a single general standby component is investigated. Here three different switch over viz. perfect switching, imperfect switching and random worm up period of the standby component are considered with some numerical examples.
(400148) George William Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Aversive stimulus differentially triggers subsecond dopamine release in reward regions
Creators: name: Bonin, K. D.
name: Wightman, R. M.
name: Park, J.
name: Budygin, E. A.
name: Grinevich, V. P.
name: Bass, C. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Aversive stimuli have a powerful impact on behavior and are considered to be the opposite valence of pleasure. Recent studies have determined some populations of VTA dopaminergic neurons are activated by several types of aversive stimuli while other distinct populations are either inhibited or unresponsive. However, it is not clear where these aversion responsive neurons project, and whether alterations in their activity translate into dopamine release in the terminal field. Here we show unequivocally that the neurochemical and anatomical substrates responsible for the perception and processing of pleasurable stimuli within the striatum are also activated by tail pinch, a classical painful and aversive stimulus. Dopamine release is triggered in the dorsal striatum and nucleus accumbens (NAc) core by tail pinch and is time locked to the duration of the stimulus, indicating that the dorsal striatum and NAc core are neural substrates, which are involved in the perception of aversive stimuli. However, dopamine is released in the NAc shell only when tail pinch is removed, indicating that the alleviation of aversive condition could be perceived as a rewarding event.
Investigation of the interphase mechanisms and welding behaviour of fast-curing epoxy based composites with co-cured thermoplastic boundary layers
Creators: name: Zweifel, Lucian
name: Brauner, Christian
Publisher: name: Elsevier
Year: 2020
Subjects: subject: 620 - Ingenieurwissenschaften und Maschinenbau

description: This study focuses on investigating thermoplastic polymers and their interphase behaviour with the fast-curing epoxy system Araldite LY3585/Aradur 3475. The three compatible thermoplastic polymers poly(methyl methacrylate) (PMMA), amorphous polyamide (PA12TR90), and poly(hydroxy ether) (phenoxy) were chosen to determine their affinity and interphase formation with the epoxy system. The final concept involves the use of a thermoplastic as a boundary layer on top of the epoxy to establish a connection between two joined parts by resistance welding. The thermoplastic boundary layer was generated by co-curing during the curing process. The experiments resulted in a high compatibility between phenoxy and PMMA in the selected epoxy system which leads to excellent mechanical properties after welding. Phenoxy showed the strongest joints, with an average lap shear strength of 25 MPa, demonstrating the high potential of this joining technique for industrial applications in the automotive and wind energy fields.
The distribution of phosphodiesterase 2A in the rat brain
Creators: name: Kelly, M. P.
name: O'Neill, S. M.
name: Kleiman, R. J.
name: Weinberg, R. J.
name: Coskran, T. M.
name: Menniti, F. S.
name: Stephenson, D. T.
name: Morton, D.
name: Schmidt, C. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The phosphodiesterases (PDEs) are a superfamily of enzymes that regulate spatio-temporal signaling by the intracellular second messengers cAMP and cGMP. PDE2A is expressed at high levels in the mammalian brain. To advance our understanding of the role of this enzyme in regulation of neuronal signaling, we here describe the distribution of PDE2A in the rat brain. PDE2A mRNA was prominently expressed in glutamatergic pyramidal cells in cortex, and in pyramidal and dentate granule cells in the hippocampus. Protein concentrated in the axons and nerve terminals of these neurons; staining was markedly weaker in the cell bodies and proximal dendrites. In addition, in both hippocampus and cortex, small populations of non-pyramidal cells, presumed to be interneurons, were strongly immunoreactive. PDE2A mRNA was expressed in medium spiny neurons in neostriatum. Little immunoreactivity was observed in cell bodies, whereas dense immunoreactivity was found in the axon tracts of these neurons and their terminal regions in globus pallidus and substantia nigra pars reticulata. Immunostaining was dense in the medial habenula, but weak in other diencephalic regions. In midbrain and hindbrain, immunostaining was restricted to discrete regions of the neuropil or clusters of cell bodies. These results suggest that PDE2A may modulate cortical, hippocampal and striatal networks at several levels. Preferential distribution of PDE2A into axons and terminals of the principal neurons suggests roles in regulation of axonal excitability or transmitter release. The enzyme is also in forebrain interneurons, and in mid- and hindbrain neurons that may modulate forebrain networks and circuits.
The Learning Management Conditions of New Normal Way of Disability-Specific School under the Office of Special Education Administration, Lopburi Province Area
Creators: name: Siriwadee Choemchaiyaphum
Publisher: name: DR.KEN Institute of Academic Development and Promotion
Year: 2023
Subjects: Conditions and Problems
Management
Learning New Ways
Disability Specific School

description: Interdisciplinary Academic and Research Journal, 3, 3, 231-238
Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood
Creators: name: Ehlers, C. L.
name: Crews, F. T.
name: Liu, W.
name: Wills, D. N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Excessive alcohol consumption is prevalent among adolescents and may result in lasting neurobehavioral consequences. The use of animal models to study adolescent alcohol exposure has the advantage of allowing for the control necessary in order to evaluate the effects of ethanol on the brain and separate such effects from genetic background and other environmental insults. In the present study the effects of moderate ethanol vapor exposure, during adolescence, on measures of neurogenesis and behavioral measures were evaluated at two different times following ethanol withdrawal, in adulthood. The two groups of Wistar rats were both exposed to intermittent ethanol vapor (14 hrs on/10 hrs off/day) for 35–36 days from PD 23-PD 58 (average blood ethanol concentration (BEC): 163 mg%). In the first group, after rats were withdrawal from vapor they were subsequently assessed for locomotor activity, conflict behavior in the open field, and behaviors in the forced swim test and then sacrificed at 72 days of age. The second group of rats were withdrawn from vapor and injected for 5 days with Bromo-deoxy-Uridine (BrdU). Over the next 8 weeks they were also assessed for locomotor activity, conflict behavior in the open field, and behaviors in the forced swim test and then sacrificed at 113/114 days of age. All rats were perfused for histochemical analyses. Ethanol vapor exposed rats displayed hypoactivity in tests of locomotion and less anxiety-like and/or more “disinhibitory” behavior in the open field conflict. Quantitative analyses of immunoreactivity revealed a significant reduction in measures of neurogenesis, progenitor proliferation, as indexed by doublecortin (DCX), Ki67, and increased markers of cell death as indexed by cleaved caspase-3, and Fluoro-Jade at 72 days, and decreases in doublecortin (DCX), and increases in cleaved caspase-3 at 114 days in the ethanol vapor exposed rats. Progenitor survival, as assessed by BrdU+, was reduced in the vapor exposed animals that were sacrificed at 114 days. The reduction seen in DCX labeled in cell counts was significantly correlated with hypoactivity at 24 hours after withdrawal as well as less anxiety-like and/or more “disinhibitory” behavior in the open field conflict test at 2 and 8 weeks following termination of vapor exposure. These studies demonstrate that behavioral measures of disinhibitory behavior correlated with decreases in neurogenesis are all significantly and persistently impacted by periadolescent ethanol exposure and withdrawal in Wistar rats.
(400143) William Lindsay Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Alternativen zu Zucker: Wie viel Süßungsmittel steckt in Erfrischungsgetränken?: Stellungnahme Nr. 006/2023 des BfR vom 07. Februar 2023
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2023
Subjects: subject: 000

description: BfR-Stellungnahmen, vol. 2023, no. 006
Adolescent Intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat
Creators: name: Crews, F. T.
name: Liu, W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The brain continues to develop through adolescence when excessive alcohol consumption is prevalent in humans. We hypothesized that binge drinking doses of ethanol during adolescence will cause changes in brain ethanol responses that persist into adulthood. To test this hypothesis Wistar rats were treated with an adolescent intermittent ethanol (AIE; 5 g/kg, i.g. 2 days on–2 days off; P25–P54) model of underage drinking followed by 25 days of abstinence during maturation to young adulthood (P80). Using markers of neuronal activation c-Fos, EGR1, and phophorylated extracellar signal regulated kinase (pERK1/2), adult responses to a moderate and binge drinking ethanol challenge, e.g., 2 or 4 g/kg, were determined. Adult rats showed dose dependent increases in neuronal activation markers in multiple brain regions during ethanol challenge. Brain regional responses correlated are consistent with anatomical connections. AIE led to marked decreases in adult ethanol PFC (prefrontal cortex) and blunted responses in the amygdala. Binge drinking doses led to the nucleus accumbens (NAc) activation that correlated with the ventral tegmental area (VTA) activation. In contrast to other brain regions, AIE enhanced the adult NAc response to binge drinking doses. These studies suggest that adolescent alcohol exposure causes long-lasting changes in brain responses to alcohol that persist into adulthood.
Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat
Creators: name: Exposto, F. G.
name: O'Buckley, S. C.
name: Kline, R. H.
name: Westlund, K. N.
name: Nackley, A. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Reduced catechol-O-methyltransferase (COMT) activity resulting from genetic variation or pharmacological depletion results in enhanced pain perception in humans and nociceptive behaviors in animals. Using phasic mechanical and thermal reflex tests (e.g. von Frey, Hargreaves), recent studies show that acute COMT-dependent pain in rats is mediated by β-adrenergic receptors (βARs). In order to more closely mimic the characteristics of human chronic pain conditions associated with prolonged reductions in COMT, the present study sought to determine volitional pain-related and anxiety-like behavioral responses following sustained as well as acute COMT inhibition using an operant 10–45°C thermal place preference task and a light/dark preference test. In addition, we sought to evaluate the effects of sustained COMT inhibition on generalized body pain by measuring tactile sensory thresholds of the abdominal region. Results demonstrated that acute and sustained administration of the COMT inhibitor OR486 increased pain behavior in response to thermal heat. Further, sustained administration of OR486 increased anxiety behavior in response to bright light, as well as abdominal mechanosensation. Finally, all pain-related behaviors were blocked by the non-selective βAR antagonist propranolol. Collectively, these findings provide the first evidence that stimulation of ARs following acute or chronic COMT inhibition drives cognitive-affective behaviors associated with heightened pain that affects multiple body sites.
Dirac Line Nodes in Inversion Symmetric Crystals
Creators: name: Kim, Youngkuk
name: Wieder, Benjamin J.
name: Kane, C. L.
name: Rappe, Andrew M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We propose and characterize a new $\mathbb{Z}_2$ class of topological semimetals with a vanishing spin--orbit interaction. The proposed topological semimetals are characterized by the presence of bulk one-dimensional (1D) Dirac Line Nodes (DLNs) and two-dimensional (2D) nearly-flat surface states, protected by inversion and time--reversal symmetries. We develop the $\mathbb{Z}_2$ invariants dictating the presence of DLNs based on parity eigenvalues at the parity--invariant points in reciprocal space. Moreover, using first-principles calculations, we predict DLNs to occur in Cu$_3$N near the Fermi energy by doping non-magnetic transition metal atoms, such as Zn and Pd, with the 2D surface states emerging in the projected interior of the DLNs. This paper includes a brief discussion of the effects of spin--orbit interactions and symmetry-breaking as well as comments on experimental implications.
Exploring properties of high-density matter through remnants of neutron-star mergers
Creators: name: Bauswein, Andreas
name: Stergioulas, Nikolaos
name: Janka, Hans-Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Remnants of neutron-star mergers are essentially massive, hot, differentially rotating neutron stars, which are initially strongly oscillating. They represent a unique probe for high-density matter because the oscillations are detectable via gravitational-wave measurements and are strongly dependent on the equation of state. The impact of the equation of state is apparent in the frequency of the dominant oscillation mode of the remnant. For a fixed total binary mass a tight relation between the dominant postmerger frequency and the radii of nonrotating neutron stars exists. Inferring observationally the dominant postmerger frequency thus determines neutron star radii with high accuracy of the order of a few hundred meters. By considering symmetric and asymmetric binaries of the same chirp mass, we show that the knowledge of the binary mass ratio is not critical for this kind of radius measurements. We summarize different possibilities to deduce the maximum mass of nonrotating neutron stars. We clarify the nature of the three most prominent features of the postmerger gravitational-wave spectrum and argue that the merger remnant can be considered to be a single, isolated, self-gravitating object that can be described by concepts of asteroseismology. The understanding of the different mechanisms shaping the gravitational-wave signal yields a physically motivated analytic model of the gravitational-wave emission, which may form the basis for template-based gravitational-wave data analysis. We explore the observational consequences of a scenario of two families of compact stars including hadronic and quark stars. We find that this scenario leaves a distinctive imprint on the postmerger gravitational-wave signal. In particular, a strong discontinuity in the dominant postmerger frequency as function of the total mass will be a strong indication for two families of compact stars. (abridged)
description: 22 pages, 17 figures; accepted for publication in EPJA
(400144) Jane Sophia Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Management of School Student Development Activities Under the Jurisdiction of Buriram Primary Educational Service Area Office 2
Creators: name: Suttinan Jansing
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Management
Learner Development Activities
Buri Ram Primary Educational Service Area Office 2

description: Interdisciplinary Academic and Research Journal, 3, 3, 353-364
The Use of Information Technology in Academic Administration of Schools under the Office of Sa Kaeo Primary Educational Service Area 1
Creators: name: Supattra Kampan
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Information Technology
Academic Administration
School
Sa Kaeo Primary Educational Service Area Office 1

description: Interdisciplinary Academic and Research Journal, 3, 3, 365-380
Developing a Model of Participatory Learning Management of Local Wisdom to Promote Vocational Skills of Learners in Educational Institutions under the Office of Maha Sarakham Primary Educational Service Area 1
Creators: name: Supaporn Lamahai
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Learning Management Mode
Participation in Local Wisdom
Vocational Skills of Learners

description: Interdisciplinary Academic and Research Journal, 3, 3, 381-400
Arguments for the Effectiveness of Human Problem Solving
Creators: name: Duris, Frantisek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.0; I.2.8
subject: 68T20

description: The question of how humans solve problem has been addressed extensively. However, the direct study of the effectiveness of this process seems to be overlooked. In this paper, we address the issue of the effectiveness of human problem solving: we analyze where this effectiveness comes from and what cognitive mechanisms or heuristics are involved. Our results are based on the optimal probabilistic problem solving strategy that appeared in Solomonoff paper on general problem solving system. We provide arguments that a certain set of cognitive mechanisms or heuristics drive human problem solving in the similar manner as the optimal Solomonoff strategy. The results presented in this paper can serve both cognitive psychology in better understanding of human problem solving processes as well as artificial intelligence in designing more human-like agents.
(400145) Caroline Anne Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Parotid Cyst: A Rare Case Report
Creators: name: Priti S Hajare
name: A Sanikop
name: Shilpa D Mallapur
name: Akash Rai
name: A.S. Harugop
name: Vinita Metgudmath
Publisher: name: Zenodo
Year: 2023

description: ABSTRACT
Major salivary gland swellings frequently lead to a differential diagnosis that are frequently linked to cystic degeneration or are totally cystic in character. Retention cysts are real cysts that infrequently affect the major salivary glands.  Only 2-5% of the swellings of the major salivary glands are non-neoplastic in nature, and 6–9% of them present as cystic lesions.1 The parotid gland cysts are equally common in both men and women, and they often manifest as a single, painless swelling in the parotid region that does not involve the skin or facial nerve below. The majority of reported instances have acquired origins and are blamed on obstructive processes. They exhibit a great deal of heterogeneity in epithelial lining type.2 Any area of the parotid gland can develop a cystic lesion, although the lips, buccal mucosa, and mouth floor are the most frequent locations. They are typically unilateral, which prompts a parotid tumour.2
Keywords: Salivary swelling Parotid cyst Benign swelling
Behavior and Factors Affecting to Decision Making on Buying Korean Artists Concert Tickets of Generation Y in Nonthaburi Province
Creators: name: Achiraya Techanaruedol
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Consumer Behavior
Decision Making
Concert Tickets
Korean Artist

description: Interdisciplinary Academic and Research Journal, 3, 3, 401-414
On The Exact Recovery Condition of Simultaneous Orthogonal Matching Pursuit
Creators: name: Determe, Jean-François
name: Louveaux, Jérôme
name: Jacques, Laurent
name: Horlin, François
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Several exact recovery criteria (ERC) ensuring that orthogonal matching pursuit (OMP) identifies the correct support of sparse signals have been developed in the last few years. These ERC rely on the restricted isometry property (RIP), the associated restricted isometry constant (RIC) and sometimes the restricted orthogonality constant (ROC). In this paper, three of the most recent ERC for OMP are examined. The contribution is to show that these ERC remain valid for a generalization of OMP, entitled simultaneous orthogonal matching pursuit (SOMP), that is capable to process several measurement vectors simultaneously and return a common support estimate for the underlying sparse vectors. The sharpness of the bounds is also briefly discussed in light of previous works focusing on OMP.
Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats
Creators: name: Glover, M. E.
name: Clinton, S. M.
name: Jackson, N. L.
name: Cohen, J. L.
name: Akil, H.
name: Pugh, P. C.
name: Fant, A. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Selective serotonin reuptake inhibitor (SSRI) antidepressants are the mainstay treatment for the 10–20% of pregnant and postpartum women who suffer major depression, but the effects of SSRIs on their children’s developing brain and later emotional health are poorly understood. SSRI use during pregnancy can elicit antidepressant withdrawal in newborns and increase toddlers’ anxiety and social avoidance. In rodents, perinatal SSRI exposure increases adult depression- and anxiety-like behavior, although certain individuals are more vulnerable to these effects than others. Our study establishes a rodent model of individual differences in susceptibility to perinatal SSRI exposure, utilizing selectively-bred Low Responder (bLR) and High Responder (bHR) rats that were previously bred for high versus low behavioral response to novelty. Pregnant bHR/bLR females were chronically treated with the SSRI paroxetine (10 mg/kg/day p.o.) to examine its effects on offspring’s emotional behavior and gene expression in the developing brain. Paroxetine treatment had minimal effect on bHR/bLR dams’ pregnancy outcomes or maternal behavior. We found that bLR offspring, naturally prone to an inhibited/anxious temperament, were susceptible to behavioral abnormalities associated with perinatal SSRI exposure (which exacerbated their Forced Swim test immobility), while high risk-taking bHR offspring were resistant. Microarray studies revealed robust perinatal SSRI-induced gene expression changes in the developing bLR hippocampus and amygdala (postnatal days 7–21), including transcripts involved in neurogenesis, synaptic vesicle components, and energy metabolism. These results highlight the bLR/bHR model as a useful tool to explore the neurobiology of individual differences in susceptibility to perinatal SSRI exposure.
How to design a genetic mating scheme: a basic training package for Drosophila genetics
Creators: name: Roote, John
name: Prokop, Andreas
Publisher: name: figshare
Year: 2021
Subjects: Biochemistry and cell biology not elsewhere classified
Evolution of developmental systems
Genetics not elsewhere classified

description: Supplementary files for: Roote, J., and Prokop, A. (2013). How to design a genetic mating scheme: a basic training package for Drosophila genetics. G3 (Bethesda) 3, 353-358. Abstract: Drosophila melanogaster is a powerful model organism for biological research. The essential
and common instrument of fly research is genetics, the art of applying Mendelian rules in the specific context of Drosophila with its unique classical genetic tools and the breadth of modern genetic tools and strategies brought in by molecular biology, transgenic technologies and the use of recombinases. Training newcomers to fly genetics is a complex and time-consuming task but too important to be left to chance. Surprisingly, suitable training resources for beginners currently are not available. Here we provide a training package for basic Drosophila genetics, designed to ensure that basic knowledge on all key areas is covered while reducing the time invested by trainers. First, a manual introduces to fly history, rationale for mating schemes, fly handling, Mendelian rules in fly, markers and balancers, mating scheme design, and transgenic technologies. Its self-study is followed by a practical training session on gender and marker selection, introducing to real flies in the laboratory. Next, through self-study of a PowerPoint presentation, trainees are guided step-by-step through a mating scheme. Finally, to consolidate knowledge, trainees are asked to design similar mating schemes reflecting routine tasks in a fly laboratory. This exercise requires individual feedback but also provides unique opportunities for trainers to spot weaknesses and strengths of each trainee and take remedial action. This training package is being successfully applied at the Manchester fly facility (5th link below) and may serve as a model for further training resources covering other aspects of fly research. A light version of the manual for teaching on undergraduate genetics courses or training short-term project students can be accessed through the last link below.
ИННОВАЦИОННАЯ ОЦЕНКА ПСИХОМОТОРНОГО РАЗВИТИЯ ДЕТЕЙ В ЗАВИСИМОСТИ ОТ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ
Creators: name: Паноев, Хуршид
Publisher: name: Zenodo
Year: 2023

description: В младенческом и раннем детстве происходит стремительное развитие мозга, заканчивается формирование мозговых структур зрительного и слухового анализаторов, завершается формирование нервной системы, формируются все структуры, необходимые для нормального развития интеллектуальных, познавательных и физических способностей ребенка [2].