Living Evidence Synthesis Updated Report. Hospital Universitario Ramón y Cajal. LE-IHD.
Creators: name: Rojas- Reyes, María
name: Bendersky, Josefina
name: Comas, David
name: Gil, Andrea
name: Plana, Maria
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: bowel inflammatory disease
subject: Continuos update
subject: Epistemonikos L.OVE Platform
subject: Evidence-based medicine
subject: Evidence Synthesis
subject: fecal microbiota transplant
subject: Inform Health Decisions
subject: Living Evidence
subject: ulcerative colitis

description: Tittle: Effectiveness and safety of Fecal Microbiota Transplant in the Treatment of ulcerative colitis: A living systematic review. Authors: Andrea Correa-Pérez Afilliation: Clinical Biostatistics Unit. Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. Faculty of Medicine. Universidad Francisco de Vitoria, Madrid, Spain Jorge de Vicente Guijarro Afilliation: Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Ramón y Cajal (IRYCIS) Madrid, Spain Andrea Gaetano Gil Afilliation: Clinical Biostatistics Unit. Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain Juan Ocaña Jiménez Afilliation: Servicio de Cirugía General y del Aparato Digestivo. Unidad de Coloproctología. Hospital Universitario Ramón y Cajal, Madrid, Spain Raquel Luengo González Afilliation: Department of Nursing and Physiotherapy. University of Alcalá, Madrid, Spain David Rigau Comas Afilliation: Iberoamerican Cochrane Centre. C/ Sant Antoni Maria Claret, 167. Pavelló 18, planta 0, 08025 Barcelona, Spain. CIBER de Epidemiología Clínica y Salud Pública (CIBERESP). Josefina Bendersky Afilliation: Institut d'Recerca-Servei d'Epidemiologia Clínica i Salut Pública. Hospital de la Santa Creu i Sant Pau. Carrer de Sant Quintí, 89, 08041 Barcelona, Spain María Ximena Rojas Reyes Afilliation: Institut d'Recerca-Servei d'Epidemiologia Clínica i Salut Pública. Hospital de la Santa Creu i Sant Pau. Carrer de Sant Quintí, 89, 08041 Barcelona, Spain María N Plana Farrás Afilliation: Unidad de Evaluación de Tecnologías Sanitarias, Ramón y Cajal University Hospital (IRYCIS), Madrid, Spain. CIBER Epidemiology and Public Health (CIBERESP) Corresponding author: Maria N Plana Farrás. Email address: nieves.plana@salud.madrid.org Postal address: Unidad de Evaluación de Tecnologías Sanitarias, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, España. CIBER de Epidemiología y Salud Pública (CIBERESP). Funding sources/sponsors: This work is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No MSCA-IF-EF-ST #894990 (to María Ximena Rojas). This work is also supported by the Health Tecnology Assesment Unit of the Hospital Universitario Ramón y Cajal. The funders and institutions did not take any part in the development of this study. Conflicts of interest: Authors have declared no conflict of interest. ABSTRACT: Objective This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of fecal microbiota transplant (FMT) for treatment of patients with moderate to severe ulcerative colitis (UC). Design Living systematic review. Database The Epistemonikos-L.OVE platform was used for evidence identification, screening, and selection. This platform has been validated as a repository for COVID-19, and proved to be a highly comprehensive source of evidence. The main search source for the L.OVE platform is the Epistemonikos database (https://www.epistemonikos.org), a comprehensive database that collates information from multiple sources to identify systematic reviews and their included primary studies, including Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, CINAHL, PsycINFO, LILACS, DARE, HTA Database, Campbell database, JBI Database of Systematic Reviews and Implementation Reports, EPPI-Centre Evidence Library. The team maintaining the Epistemonikos-L·OVE platform devised the literature search, using the following approach: i) Identification of terms relevant to the population and intervention components of the search strategy, using Word2vec technology to the corpus of documents available in Epistemonikos Database; ii) Discussion of search terms with methods experts to identify relevant, irrelevant and missing terms, iii) Creation of a sensitive boolean strategy encompassing all the relevant terms. The results of the literature searches were automatically incorporated into the L·OVE platform (automated retrieval) and organized in the corresponding L.OVE of “Fecal microbiota transplant for ulcerative colitis”. Methods To prioritize the fecal microbiota transplantation administration route, comparators and outcomes more relevant for supporting the clinical decisions in the treatment of ulcerative colitis patients, we performed a Delphi process conducted by an expert panel in the field of gastroenterology and colorectal surgery. Given Delphi panel results, we decided to include randomized studies evaluating the efficacy and safety of FMT versus any active treatment in patients with moderate to severe ulcerative colitis. Measures included clinical remission, clinical relapse, endoscopic release, clinical response, free time without corticosteroid treatment, serious adverse events and health related quality of life. Two reviewers independently screened each study for eligibility. We planned to extract data and assess the risk of bias using the ROB-2 tool by duplicate. We also planned to apply the GRADE approach to assess the certainty of the evidence for each outcome. This is the first update report since our previous baseline evidence synthesis report for this question. Last search date 11/07/2022. Results Since the beginning of this living review, searches have retrieved 202 references to the L·OVE platform. 28 were considered potentially eligible and 16 were reviewed in full text. The initial baseline report did not include any randomized clinical trial that evaluated the use of FMT compared to the use of any active treatment in patients with moderate to severe ulcerative colitis. No new randomized clinical trials were included for this update. Conclusions No randomized trials evaluating the effect of FMT versus any active treatment in patients with moderate to severe ulcerative colitis have been identified. As of this update, this Living Systematic Review will be withdrawn from the living model, as research on the review (PICO) question is not emerging. © 2022 Hospital Universitario Ramón y Cajal, Spain/ EU H2020, Living Evidence to Inform Health Decisions Project. All rights reserved.