cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phylogenetic placement of metagenomic reads using the minimum evolution principle
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Algorithms
Base Sequence
Databases, Genetic
Evolution, Molecular
Likelihood Functions
Metagenomics
Phylogeny
Sequence Alignment

description: © 2014 Filipski et al. Background: A central problem of computational metagenomics is determining the correct placement into an existing phylogenetic tree of individual reads (nucleotide sequences of varying lengths, ranging from hundreds to thousands of bases) obtained using next-generation sequencing of DNA samples from a mixture of known and unknown species. Correct placement allows us to easily identify or classify the sequences in the sample as to taxonomic position or function. Results: Here we propose a novel method (PhyClass), based on the Minimum Evolution (ME) phylogenetic inference criterion, for determining the appropriate phylogenetic position of each read. Without using heuristics, the new approach efficiently finds the optimal placement of the unknown read in a reference phylogenetic tree given a sequence alignment for the taxa in the tree. In short, the total resulting branch length for the tree is computed for every possible placement of the unknown read and the placement that gives the smallest value for this total is the best (optimal) choice. By taking advantage of computational efficiencies and mathematical formulations, we are able to find the true optimal ME placement for each read in the phylogenetic tree. Using computer simulations, we assessed the accuracy of the new approach for different read lengths over a variety of data sets and phylogenetic trees. We found the accuracy of the new method to be good and comparable to existing Maximum Likelihood (ML) approaches. Conclusions: In particular, we found that the consensus assignments based on ME and ML approaches are more correct than either method individually. This is true even when the statistical support for read assignments was low, which is inevitable given that individual reads are often short and come from only one gene.
Self force on a point-like source coupled with massive scalar field
Creators: name: Yaremko, Yurij
Publisher: name: arXiv
Year: 2009
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: The problem of determining the radiation reaction force experienced by a scalar charge moving in flat spacetime is investigated. A consistent renormalization procedure is used, which exploits the Poincaré invariance of the theory. Radiative parts of Noether quantities carried by massive scalar field are extracted. Energy-momentum and angular momentum balance equations yield Harish-Chandra equation of motion of radiating charge under the influence of an external force. This equation includes effect of particle's own field. The self force produces a time-changing inertial mass.
description: 18 pages
Excavating a Beautiful 18th Century Landscape Garden
Creators: name: Bernardi, Valentina
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Circulating tumor cells in newly diagnosed inflammatory breast cancer
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Female
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammatory Breast Neoplasms
Kaplan-Meier Estimate
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Neoplastic Cells, Circulating
Prognosis
Retrospective Studies
Risk Factors
Treatment Outcome
Young Adult

description: © Mego et al. Introduction: Circulating tumor cells (CTCs) are an independent prognostic factor for progression-free survival (PFS) and overall survival (OS) in patients with metastatic breast cancer. Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. The prognostic value of a CTC count in newly diagnosed IBC has not been established. The aim of this study was to assess the prognostic value of a baseline CTC count in patients with newly diagnosed IBC. Methods: This retrospective study included 147 patients with newly diagnosed IBC (77 with locally advanced and 70 with metastatic IBC) treated with neoadjuvant therapy or first-line chemotherapy during the period from January 2004 through December 2012 at The University of Texas MD Anderson Cancer Center. CTCs were detected and enumerated by using the CellSearch system before patients were started with chemotherapy. Results: The proportion of patients with ≥1 CTC was lower among patients with stage III than among patients with metastatic IBC (54.5% versus 84.3%; P=0.0002); the proportion of patients with ≥5 CTCs was also lower for stage III than for metastatic IBC (19.5% versus 47.1%; P=0.0004). Patients with fewer than five CTCs had significantly better progression-free survival (PFS) (hazard ratio (HR)=0.60; P=0.02) and overall survival (HR=0.59; P=0.03) than patients with five or more CTCs. Among patients with stage III IBC, there was a nonsignificant difference in PFS (HR=0.66; 95% confidence interval (CI), 0.31 to 1.39; P=0.29) and OS (HR=0.54; 95% CI, 0.24 to 1.26; P=0.48) in patients with no CTCs compared with patients with one or more CTCs. In multivariate analysis, CTC was prognostic for PFS and OS independent of clinical stage. Conclusions: CTCs can be detected in a large proportion of patients with newly diagnosed IBC and are a strong predictor of worse prognosis in patients with newly diagnosed IBC.
Working memory and intelligibility of hearing-aid processed speech
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: aging
cognition
compression
hearing aid
hearing loss
intelligibility
quality

description: © 2015 Souza, Arehart, Shen, Anderson and Kates. Previous work suggested that individuals with low working memory capacity may be at a disadvantage in adverse listening environments, including situations with background noise or substantial modification of the acoustic signal. This study explored the relationship between patient factors (including working memory capacity) and intelligibility and quality of modified speech for older individuals with sensorineural hearing loss. The modification was created using a combination of hearing aid processing [wide-dynamic range compression (WDRC) and frequency compression (FC)] applied to sentences in multitalker babble. The extent of signal modification was quantified via an envelope fidelity index. We also explored the contribution of components of working memory by including measures of processing speed and executive function. We hypothesized that listeners with low working memory capacity would perform more poorly than those with high working memory capacity across all situations, and would also be differentially affected by high amounts of signal modification. Results showed a significant effect of working memory capacity for speech intelligibility, and an interaction between working memory, amount of hearing loss and signal modification. Signal modification was the major predictor of quality ratings. These data add to the literature on hearing-aid processing and working memory by suggesting that the working memory-intelligibility effects may be related to aggregate signal fidelity, rather than to the specific signal manipulation. They also suggest that for individuals with low working memory capacity, sensorineural loss may be most appropriately addressed with WDRC and/or FC parameters that maintain the fidelity of the signal envelope.
Effects of lower tiers of government healthcare facilities on unmet need for contraception and contraception use in Bangladesh
Creators: name: Khan, Md Nuruzzaman
name: Khanam, Shimlin Jahan
name: Khan, Md Mostaured Ali
name: Islam, Md
name: Harris, Melissa L
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4203
subject: Health services and systems

description: Background: In low- and middle-income countries (LMICs), including Bangladesh, modern contraception use remains lower than desired, resulting in a higher unmet need. A potential factor contributing to lower contraceptive use is reduced access to and use of lower tiers of government healthcare facilities, including home visits by family welfare assistants (FWAs), as well as women’s visits to community and satellite clinics. These relationships, however, are still unexplored in Bangladesh and LMICs more broadly. The aim of this study was to explore the effects of lower tiers of government healthcare facilities on unmet needs for contraception and contraception use in Bangladesh. Methods: Data from 17,585 sexually active married women were analyzed from the 2017 Bangladesh Demographic and Health Survey. The outcome variables were any contraceptive use, modern contraceptive use, unmet need for contraception, and unmet need for modern contraception. The explanatory variables considered were respondents’ home visits by FWAs, respondents’ visits to a community clinic, and respondents’ visits to a satellite clinic. Multilevel mixed-effect Poisson regression with robust variance was used to determine the association between the outcome and explanatory variables, adjusted for individual-, household-, and community-level factors. Results: Approximately 18% of respondents were visited by FWAs in the three months prior to the survey date and only 3.4% and 3.1% of women attended community and satellite clinics, respectively. Women who reported being visited by FWAs in the three months prior to the survey were approximately 36% less likely to report an unmet need for modern contraception and 42% more likely to report using modern contraception than women who did not report such a visit. A higher likelihood of unmet need for contraception and a lower likelihood of contraception use were found among women who did not visit these community or satellite clinics or visited these clinics for other reasons than collecting contraception as compared to women who visited these clinics to collect contraception. Conclusion: Home visits by FWAs to respondents’ homes to provide contraception as well as respondents’ visits to satellite and community clinics play a major role in Bangladesh to ensure contraception use and reduce the unmet need for contraception. However, their coverage is quite low in Bangladesh. The findings suggest an urgent need for greater government initiatives to increase the number of FWAs and proper monitoring of them at the field level.
Breakdown of thermodynamic equilibrium for DNA hybridization in microarrays
Creators: name: Hooyberghs, J.
name: Baiesi, M.
name: Ferrantini, A.
name: Carlon, E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Biomolecules (q-bio.BM)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Test experiments of hybridization in DNA microarrays show systematic deviations from the equilibrium isotherms. We argue that these deviations are due to the presence of a partially hybridized long-lived state, which we include in a kinetic model. Experiments confirm the model predictions for the intensity vs. free energy behavior. The existence of slow relaxation phenomena has important consequences for the specificity of microarrays as devices for the detection of a target sequence from a complex mixture of nucleic acids.
description: 4 pages, 4 figures
Validation of a parent report questionnaire
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: assessment
feeding
gastrointestinal problems
infant
validity
Feeding Behavior
Female
Gastrointestinal Tract
Humans
Infant
Infant, Newborn
Male
Parents
Reproducibility of Results
Surveys and Questionnaires

description: © 2015 SAGE Publications. Objective. To evaluate the reliability and validity of the Infant Gastrointestinal Symptom Questionnaire (IGSQ), a tool to assess feeding tolerance in infants. Methods. Qualitative methods were used to develop IGSQ content across 5 symptom clusters, yielding a 13-item index of parent-reported infant digestion and elimination behaviors over the prior 7 days. Classical psychometric methods evaluated factor structure, interrater and retest reliability, and validity in 4 prospective studies of 836 infants. Results. Interrater and retest reliability were acceptable to good. IGSQ Index score was highly correlated (r = 0.89) with daily parent reports. IGSQ scores were significantly different between infants whose parents planned to switch formulas because of perceived feeding problems and those without parental concerns. Conclusions. The IGSQ is a practical, reliable, and valid method for assessment of infant gastrointestinal-related behaviors. Its use in clinical studies can provide empirical evidence to advance parent education regarding both normal and clinically meaningful feeding-related behaviors.
Investigating Urbanism at Ancient Gabii
Creators: name: Gabii
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Triple negative breast cancer: Looking for the missing link between biology and treatments
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: breast cancer
triple negative
oncology
treatments
biology

description: The so called "Triple Negative Breast Cancer" (TNBC) represents approximately 15-20% of breast cancers. This acronym simply means that the tumour does not express oestrogen receptor (ER) and progesterone receptor (PR) and does not exhibit amplification of the human epidermal growth factor receptor 2 (HER2) gene. Despite this unambiguous definition, TNBCs are an heterogeneous group of tumours with just one common clinical feature: a distinctly aggressive nature with higher rates of relapse and shorter overall survival in the metastatic setting compared with other subtypes of breast cancer. Because of the absence of well-defined molecular targets, cytotoxic chemotherapy is currently the only treatment option for TNBC. In the last decades, the use of more aggressive chemotherapy has produced a clear improvement of the prognosis in women with TNBC, but this approach results in an unacceptable deterioration in the quality of life, also if some support therapies try to relieve patients from distress. In addition, there is the general belief that it is impossible to further improve the prognosis of TNBC patients with chemotherapy alone. In view of that, there is a feverish search for new "clever drugs" able both to rescue chemo-resistant, and to reduce the burden of chemotherapy in chemo-responsive TNBC patients. A major obstacle to identifying actionable targets in TNBC is the vast disease heterogeneity both inter-tumour and intra-tumour and years of study have failed to demonstrate a single unifying alteration that is targetable in TNBC. TNBC is considered the subtype that best benefits from the neoadjuvant model, since the strong correlation between pathological Complete Response and long-term Disease-Free-Survival in these patients. In this review, we discuss the recent discoveries that have furthered our understanding of TNBC, with a focus on the subtyping of TNBC. We also explore the implications of these discoveries for future treatments and highlight the need for a completely different type of clinical trials.
A Universal Central Engine Hypothesis for Short and Long GRBs
Creators: name: Eichler, David
name: Guetta, Dafne
name: Manis, Hadar
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: It is noted that X-ray tails (XRTs) of short, hard $γ$-ray bursts (SHBs) are similar to X-ray flashes (XRFs). We suggest a universal central engine hypothesis, as a way of accounting for this curiosity, in which SHBs differ from long $γ$-ray bursts (GRBs) in prompt emission because of the differences in the host star and attendant differences in the environment they present to the compact central engine (as opposed to differences in the central engine itself). Observational constraints and implications are discussed, especially for confirming putative detections of gravitational waves from merging compact objects.
description: 3 figures, one with two panels
title: Возможности повышения конкурентоспособности предприятия совершенствованием логистических подходов
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2021

description: В учебном пособии изложены некоторые подходы к использованию современного логистического подхода в управлении современными торгово-производственными предприятиями. Кроме теоретической базы в нем изложены основы и примеры использования такого подхода и математического аппарата в различных приложениях, причем каждая тема иллюстрируется примерами из деятельности конкретного предприятия ООО «ТК “ЗАРД”». Подробно представлено решение некоторых из рассматриваемых примеров с помощью одной из современных систем компьютерной математики — пакета прикладных программ Mathcad, которая делает анализ различных подходов управления более эффективным и позволяет сосредоточить внимание читателя на логике методов и алгоритмов, освобождая от необходимости освоения громоздких вычислительных процедур. Издание также снабжено конкретным цифровым материалом для лучшего понимания. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие может быть использовано студентами, обучающимися по направлениям подготовки 15.03.02, 15.04.02 «Технологические машины и оборудование», 38.03.02, 38.04.02 «Менеджмент» (профиль «Управление логистическими системами»), при изучении дисциплин «Рациональное использование сырьевых ресурсов», «Проектная деятельность в построении процессов и аппаратов переработки растительного сырья», «Математический инструментарий в решении задач логистики». Издание также будет полезно студентам и аспирантам других экономических направлений и специалистам, работающим в сфере менеджмента и логистики.
Equivariant Dimensional Reduction and Quiver Gauge Theories
Creators: name: Dolan, Brian P.
name: Szabo, Richard J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review recent applications of equivariant dimensional reduction techniques to the construction of Yang-Mills-Higgs-Dirac theories with dynamical mass generation and exactly massless chiral fermions.
description: 10 pages; Based on invited talk given by the first author at the 2nd School on "Quantum Gravity and Quantum Geometry" session of the 9th Hellenic School on Elementary Particle Physics and Gravity, Corfu, Greece, September 13-20 2009. To be published in General Relativity and Gravitation
title: Возможности экструзии при переработке вторичного пищевого сырья
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2021

description: В монографии изложены некоторые подходы к использованию современного ресурсосберегающего производства предприятиями, расположенными в условиях с ограниченными возможностями поставки пищевого сырья, например, в Арктике или на Крайнем Севере. Подробно представлено решение некоторых из рассматриваемых проблем с помощью одной из современных систем планирования эксперимента, которая делает анализ различных подходов к производству более эффективным и позволяет сосредоточить внимание читателя на логике исследований, освобождая от необходимости освоения громоздких вычислительных процедур. Издание также снабжено конкретным цифровым материалом для лучшего понимания. Монография может быть полезна специалистам, проектирующим оборудование, работающее в условиях необходимости переработки вторичного пищевого сырья, и работникам, эксплуатирующим это оборудование.
Mystery, Diversity and the Joy of Archaeology
Creators: name: Hadley, Pat
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
The molecular dimension of microbial species: 2. Synechococcus strains representative of putative ecotypes inhabiting different depths in the Mushroom Spring microbial mat exhibit different adaptive and acclimative responses to light
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: microbial species
light adaptation
light acclimation
cyanobacteria
photosynthesis

description: © 2015 Nowack, Olsen, Schaible, Becraft, Shen, Klapper, Bryant and Ward. Closely related strains of thermophilic Synechococcus were cultivated from the microbial mats found in the effuent channels of Mushroom Spring, Yellowstone National Park (YNP). These strains have identical or nearly identical 16S rRNA sequences but are representative of separate, predicted putative ecotype (PE) populations, which were identified by using the more highly resolving psaA locus and which predominate at different vertical positions within the 1-mm-thick upper-green layer of the mat. Pyrosequencing confirmed that each strain contained a single, predominant psaA genotype. Strains differed in growth rate as a function of irradiance. A strain with a psaA genotype corresponding to a predicted PE that predominates near the mat surface grew fastest at high irradiances, whereas strains with psaA genotypes representative of predominant subsurface populations grew faster at low irradiance and exhibited greater sensitivity to abrupt shifts to high light. The high-light-adapted and low-light-adapted strains also exhibited differences in pigment content and the composition of the photosynthetic apparatus (photosystem ratio) when grown under different light intensities. Cells representative of the different strains had similar morphologies under low-light conditions, but under high-light conditions, cells of low-light-adapted strains became elongated and formed short chains of cells. Collectively, the results presented here are consistent with the hypothesis that closely related, but distinct, ecological species of Synechococcus occupy different light niches in the Mushroom Spring microbial mat and acclimate differently to changing light environments.
title: Microcalorimetry of protein stability and interactions
Creators: name: Robertson, Stephen R.
Publisher: name: University of Glasgow
Year: 1995
Subjects: subject: Biophysics.

description: Protein stability and interactions in a number of systems have been examined using a range of calorimetric and spectroscopic methods. The thermodynamics of unfolding of bovine alpha-lactalbumin (BLA) was studied using differential scanning calorimetry (DSC) under a variety of pH and calcium ion concentration conditions. Values for AG2, AH2 and AS2 under each of these conditions were obtained, and these data were used to calculate a value for ACp. The information thus obtained for the wild type (WT) protein was then compared to data obtained under similar conditions for a modified form of the protein (3SS-BLA) which contains only three of the usual four disulphide bonds, the other (C6-C120) having been specifically reduced and blocked. In this way it was possible to gain information on the role of this disulphide bond for the stability of the protein. In line with current theory it was found that the modified form of the protein was less stable and this was accountable for in terms of entropy. However, the difference in unfolding entropy between the two forms (AAS) was less than may be anticipated under the current theory. Fluorescence spectroscopy was employed to show whether or not removal of the disulphide bond caused any significant alteration in the dynamics of the native state. It was found that 3SS-BLA was significantly more flexible than its wild type counterpart, and this may account for the unexpectedly low AAS. DSC was also used to study the effect of heavy and light water on the stability of hen egg white lysozyme (HEWL). It was found in heavy water the protein was enthalpically destabilised, but this was more than offset by an entropic stabilisation, a finding which is in line with model compound studies. Through this work it was also noticed that thermal aggregation of proteins increases with concentration. DSC was further employed to study partially proteolyzed Pf1 gene five protein (Pf1- gVp) and complex (Pf1-gVc). It was found that removal of the flexible N-terminal domain had no apparent effect on thermal stability of the complex and therefore is unlikely to be involved in protein-protein interactions in the complex. The Tm of this complex was found to be concentration dependent which shows that the system undergoes cooperative dissociation and unfolding. Isothermal titration calorimetry (ITC) was used alongside DSC to study the coat protein of the bacteriophage MS2. ITC measurements on the binding of a specific RNA 19-mer to the coat protein were made, forming a basis for future work. The Tm measured in DSC was found to be comparable to literature estimates. ITC was also employed to study the binding of arginine (Arg) to the protein AhrC. It was found that three molecules of Arg bind per protein hexamer to a strong site and that there is a second, much weaker site or sites which bind a large number of molecules.
Targeting CXCR1 on breast cancer stem cells: Signaling pathways and clinical application modelling
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: preclinical MRI

description: In breast cancer it has been proposed that the presence of cancer stem cells may drive tumor initiation, progression and recurrences. IL-8, up-regulated in breast cancer, and associated with poor prognosis, increases CSC self-renewal in cell line models. It signals via two cell surface receptors, CXCR1 and CXCR2. Recently, the IL-8/CXCR1 axis was proposed as an attractive pathway for the design of specific therapies against breast cancer stem cells. Reparixin, a powerful CXCR1 inhibitor, was effective in reducing in vivo the tumour-initiating population in several NOD/SCID mice breast cancer models, showing that the selective targeting of CXCR1 and the combination of reparixin and docetaxel resulted in a concomitant reduction of the bulk tumour mass and CSC population. The available data indicate that IL-8, expressed by tumour cells and induced by chemotherapeutic treatment, is a key regulator of the survival and self-renewal of the population of CXCR1-expressing CSC. Consequently, this investigation on the mechanism of action of the reparixin/paclitaxel combination, was based on the observation that reparixin treatment contained the formation of metastases in several experimental models. However, specific data on the formation of breast cancer brain metastases, which carry remarkable morbidity and mortality to a substantial proportion of advanced breast cancer patients, have not been generated. The obtained data indicate a beneficial use of the drug combination reparixin and paclitaxel to counteract brain tumour metastasis due to CSC, probably due to the combined effects of the two drugs, the pro-apoptotic action of paclitaxel and the cytostatic and anti-migratory effects of reparixin.
The Benefits of a Temperature Monitoring System in the Fourth Industrial Revolution
Creators: name: Isa A.I.
name: Muhammad A. B
Publisher: name: gjrpublication
Year: 2024

description: High fever illness claims numerous lives annually, prompting this essay’s exploring of innovative solutions. The fourth Industrial Revolution (4IR) offers technological advancements, including digital inventions, to address this challenge. Non-contact temperature detection systems utilise infrared radiation to measure object temperatures and ambient surroundings. Recent microelectronics and electronic advancements enable the development of reliable, affordable monitoring systems for businesses, organisations, institutions, schools, and individuals to identify high-temperature patients and prevent disease spread. This study examines the benefits of temperature monitoring systems, highlighting their potential to save lives and enhance public health.
Ligational behavior of bidentate NO-donor, 2-(((1H-1,2,4-triazol-5-yl)imino)methyl)-4-(o-tolyldiazenyl)phenol towards VO2+, Fe3+, Ru3+, Co2+, Mn2+, Ni2+, Cu2+ Zn2+ and ions preparation, experimental, theoretical characterization, and microbicidal investigation
Creators: name: Saleem, Qaid M.
name: Ebrahium, Mohamad M.
name: Al-Hakimi, Ahmed N.
name: shakdofa, Adel M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Novel bidentate chelator, 2-(((1H-1,2,4-triazol-5-yl)imino)methyl)-4-(o-tolyldiazenyl)phenol was employed for designing and preparation of transition metallic complexes. The synthetics were characterized based on various analytical, spectral, and theoretical tools. Based on the various analysis data, the azo-Schiff base chelator (H2L) linked with metallic cations as a neutral/uni-negative bidentate chelator via the protonated/deprotonated hydroxyl oxygen and azomethine nitrogen atoms adopted a distorted octahedral, tetrahedral, or square planar geometry. The mass spectroscopy confirmed that the molecular weights of azo-Schiff base and some of its complexes closely match with that of the estimated m/z values. Additionally, the structure of the azo-Schiff base ligand and some metallic complexes were studied by Density functional theory (DFT) calculations to assess the molecular orbitals (LUMO&HOMO) as well as the molecules electrostatic potential (MEP) to complete the picture. The synthetics were evaluated for their in vitro activity against Escherichia coli, Aspergillus niger, and Bacillus subtilis. According to this research, unbound ligand molecules are inactive while their metallic complexes have low to moderate activity.
Synthesis and properties of lysosome-specific photoactivatable probes for live-cell imaging
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015

description: © The Royal Society of Chemistry. Fluorescent dyes have become increasingly important in cell biology since they enable high signal-to-noise and selectivity in visualizing subcellular organelles. Photoactivatable dyes allow for tracking and monitoring of a subset of cells or organelles. Here, we report the synthesis and application of a new class of large Stokes shift fluorescent dyes that are water-soluble, cell permeable, non-cytotoxic, and lysosome-specific. Additionally, we demonstrate temporally controlled sequential photoactivation of individual cells in close spatial proximity.
ปัจจัยที่มีอิทธิพลต่อพฤติกรรมความปลอดภัยจากการติดเชื้อไวรัสโคโรนา 2019 ของบุคลากรในโรงพยาบาลบุรีรัมย์
Creators: name: ชุติมา ดีสวัสดิ์
Publisher: name: ศูนย์อนามัยที่ 9 นครราชสีมา
Year: 2564
Subjects: บรรยากาศความปลอดภัย
พฤติกรรมความปลอดภัย
การติดเชื้อไวรัสโคโรนา 2019
บุคคลากรโรงพยาบาล

description: วารสารศูนย์อนามัยที่ 9, 15, 38, 399-413
ปัจจัยที่มีความสัมพันธ์กับพฤติกรรมความปลอดภัยในการป้องกันการเกิดเพลิงไหม้ในครัวเรือนบ้านบก อำเภอม่วงสามสิบ จังหวัดอุบลราชธานี
Creators: name: ชัยกฤต ยกพลชนชัย
Publisher: name: ศูนย์อนามัยที่ 9 นครราชสีมา
Year: 2564
Subjects: พฤติกรรมการป้องกันการเกิดเพลิงไหม้
ความปลอดภัยในครัวเรือน

description: วารสารศูนย์อนามัยที่ 9, 15, 38, 414-427
title: Исследование возможностей совершенствования механизма планирования и управления экономическими системами в условиях глобализации бизнеса
Creators: name: ELS IPR BOOKS
Publisher: name: Вузовское образование
Year: 2021

description: В представленной монографии основное внимание уделено содержанию и общесистемным характеристикам обеспечения процесса планирования и управления экономическими системами, параметрическим характеристикам процесса управления, содержательным компонентам, обеспечивающим процесс планирования и управления; инструментам и методам, направленным на реализацию процессов планирования и управления. Полученные в монографии результаты могут быть использованы региональными органами власти в целях улучшения планирования и управления экономическими системами в условиях глобализации бизнеса.
Disorder effects on the superconducting properties of BaFe$_{1.8}$Co$_{0.2}$As$_2$ single crystals
Creators: name: Eisterer, M.
name: Zehetmayer, M.
name: Weber, H. W.
name: Jiang, J.
name: Weiss, J. D.
name: Yamamoto, A.
name: Hellstrom, E. E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Single crystals of superconducting BaFe$_{1.8}$Co$_{0.2}$As$_2$ were exposed to neutron irradiation in a fission reactor. The introduced defects decrease the superconducting transition temperature (by about 0.3 K) and the upper critical field anisotropy (e.g. from 2.8 to 2.5 at 22 K) and enhance the critical current densities by a factor of up to about 3. These changes are discussed in the context of similar experiments on other superconducting materials.
Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Abdominal Pain
Body Mass Index
Double-Blind Method
Dyspepsia
Electrodes
Female
Follow-Up Studies
Heartburn
Humans
Male
Middle Aged
Nerve Block
Obesity, Morbid
Risk Assessment
Treatment Outcome
United States
Vagus Nerve
Weight Loss

description: © 2015 Scott A. Shikora et al. Background/Objectives. Vagal block therapy (vBloc) is effective for moderate to severe obesity at one year. Subjects/Methods. The ReCharge trial is a double-blind, randomized controlled clinical trial of 239 participants with body mass index (BMI) of 40 to 45 kg/m or 35 to 40 kg/m with one or more obesity-related conditions. Interventions were implantation of either vBloc or Sham devices and weight management counseling. Mixed models assessed percent excess weight loss (%EWL) and total weight loss (%TWL) in intent-to-treat analyses. At 18 months, 142 (88%) vBloc and 64 (83%) Sham patients remained enrolled in the study. Results. 18-month weight loss was 23% EWL (8.8% TWL) for vBloc and 10% EWL (3.8% TWL) for Sham (P<0.0001). vBloc patients largely maintained 12-month weight loss of 26% EWL (9.7% TWL). Sham regained over 40% of the 17% EWL (6.4% TWL) by 18 months. Most weight regain preceded unblinding. Common adverse events of vBloc through 18 months were heartburn/dyspepsia and abdominal pain; 98% of events were reported as mild or moderate and 79% had resolved. Conclusions. Weight loss with vBloc was sustained through 18 months, while Sham regained weight between 12 and 18 months. vBloc is effective with a low rate of serious complications.
การรับรู้ความสามารถในการควบคุมพฤติกรรม และพฤติกรรมการบริโภคอาหารในผู้สูงอายุที่เป็นโรคเบาหวานที่ควบคุมระดับน้ำตาลในเลือดไม่ได้
Creators: name: วินัฐ ดวงแสนจันทร์
Publisher: name: ศูนย์อนามัยที่ 9 นครราชสีมา
Year: 2564
Subjects: การรับรู้การควบคุมพฤติกรรม, พฤติกรรมการบริโภคอาหาร, ผู้สูงอายุ, โรคเบาหวานที่ควบคุมระดับน้ำตาลไม่ได้

description: วารสารศูนย์อนามัยที่ 9, 15, 38, 428-442
Flexible Erwerbsbürgerschaft auch für Frauen? Herausforderungen der Arbeitsmarkt-, Familien- und Bildungspolitik in Deutschland
Creators: name: Gottschall, Karin
Publisher: name: De Gruyter Oldenbourg
Year: 2002
Subjects: subject: -
subject: 300

description: Ausgangspunkt des Beitrags ist die jüngere politische Orientierung am Leitbild 'flexibler Erwerbsbürgerschaft'. Sie wird in einigen europäische Länder bereits seit längerem in Form einer aktivierenden Arbeitsmarkt- und Sozialpolitik realisiert. Für die Bundesrepublik, so die hier vertretene These, stellt die Orientierung an einer 'Beschäftigungsfähigkeit für alle' eine besondere Herausforderung dar. Denn die sozialstaatlichen Rahmenbedingungen sind auch im wiedervereinigten Deutschland nach wie vor vorrangig an der Arbeitsmarktteilhabe eines männlichen Familienernährers und weniger an der Beschäftigungsfähigkeit von Frauen bzw. von Eltern orientiert. Der Beitrag diskutiert strukturelle Rahmenbedingungen und Reformoptionen in den Bereichen Arbeitsmarkt-, Familien- und Bildungspolitik und fragt abschließend nach dem demokratischen Potential flexibler Erwerbsbürgerschaft.
Spitzer Spectral Mapping of Supernova Remnant Cassiopeia A
Creators: name: Smith, J. D. T.
name: Rudnick, Lawrence
name: Delaney, Tracey
name: Rho, Jeonghee
name: Gomez, Haley
name: Kozasa, Takashi
name: Reach, William
name: Isensee, Karl
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the global distribution of fine structure infrared line emission in the Cassiopeia A supernova remnant using data from the Spitzer Space Telescope's Infrared Spectrograph. We identify emission from ejecta materials in the interior, prior to their encounter with the reverse shock, as well as from the post-shock bright ring. The global electron density increases by >~100 at the shock to ~10^4 cm^-3, providing evidence for strong radiative cooling. There is also a dramatic change in ionization state at the shock, with the fading of emission from low ionization interior species like [SiII], giving way to [SIV] and, at even further distances, high-energy X-rays from hydrogenic silicon. Two compact, crescent-shaped clumps with highly enhanced neon abundance are arranged symmetrically around the central neutron star. These neon crescents are very closely aligned with the "kick" direction of the compact object from the remnant's expansion center, tracing a new axis of explosion asymmetry. They indicate that much of the apparent macroscopic elemental mixing may arise from different compositional layers of ejecta now passing through the reverse shock along different directions.
description: 9 pages, 8 figures, accepted by ApJ
Analysis of growth of Vancouver's central business district
Creators: name: Jamieson, William Sinclair
Publisher: name: University of British Columbia
Year: 2011

description: The primary purpose of this thesis is to examine development of Vancouver's Central Business District to test the hypothesis that "growth takes the path of least resistance" within the central core of Vancouver. Vancouver's city centre is considered to be the office headquarters of the Lower Mainland Area. Fulfillment of this role has resulted in the construction of twenty new office buildings in the past six years. This represents an increase of almost three million square feet which is 50% over the standing stock of 1965. The researcher had an opportunity to participate in this very active real estate market and as a result of such participation formulated the above growth hypothesis. This study briefly reviews existing theories of city growth and follows with a history of growth in Vancouver's central core. The thesis then describes the mechanics and results of a land use study of Vancouver's Central Area. The results of this extensive land use study are used to test the growth hypothesis mentioned in the initial chapter of this abstract. This test shows that growth in Vancouver does take the path of least resistance. This resistance to development may be tangible or intangible or a combination of both. Physical resistance arises from current patterns of building and/or land use — i.e. the density of the standing stock. Given the same relative location and degree of desirability, vacant land will be developed before underdeveloped land. Thus if there are well located vacant sites within the core it is easy to predict the direction of growth. For underdeveloped areas the study employs indices such as floor space index, the value of building per square foot of land area, and value of building per square foot of building area, to determine which sites are the most underdeveloped and would offer the least resistance in terms of cost to assemble for redevelopment purposes. The study also reviews factors such as the pattern of land and building ownership. The study concludes that these are intangible factors that can cause resistance to growth and must be considered when examining growth in the C.B.D. The study proceeds a step further by using the "least resistance" theory to identify areas of future growth. The area which offers the least resistance is chosen and the economic model developed indicates that development on the site would be profitable, thus could be considered a likely area for future growth.
Exact theoretical description of two ultracold atoms in a single site of a 3D optical lattice using realistic interatomic interaction potentials
Creators: name: Grishkevich, Sergey
name: Saenz, Alejandro
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: A theoretical approach was developed for an exact numerical description of a pair of ultracold atoms interacting via a central potential that are trapped in a three-dimensional optical lattice. The coupling of center-of-mass and relative-motion coordinates is explicitly considered using a configuration-interaction (exact-diagonalization) technique. Deviations from the harmonic approximation are discussed for several heteronuclear alkali-metal atom pairs trapped in a single site of an optical lattice. The consequences are discussed for the analysis of a recent experiment [C. Ospelkaus et al, Phys. Rev. Lett. 97, 120402 (2006)] in which radio-frequency association was used to create diatomic molecules from a fermionic and a bosonic atom and to measure their binding energies close to a magnetic Feshbach resonance.
description: 18 pages, 10 figures
Loot Busters
Creators: name: Phdiva
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Lots of Little Jobs and One Big Job
Creators: name: Rocks-Macqueen, Doug
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.