cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
Creators: name: Brenner, David
name: Müller, Kathrin
name: Lattante, Serena
name: Yılmaz, Rüstem
name: Knehr, Antje
name: Freischmidt, Axel
name: Ludolph, Albert C.
name: Andersen, Peter M.
name: Weishaupt, Jochen H.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Amyotrophic lateral sclerosis
subject: ALS
subject: Frontotemporal dementia
subject: FTD
subject: TBK1
subject: FUS
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health

description: Abstract Mutations in FUS and TBK1 often cause aggressive early-onset amyotrophic lateral sclerosis (ALS) or a late-onset ALS and/or frontotemporal dementia (FTD) phenotype, respectively. Co-occurrence of mutations in two or more Mendelian ALS/FTD genes has been repeatedly reported. However, little is known how two pathogenic ALS/FTD mutations in the same patient interact to shape the final phenotype. We screened 28 ALS patients with a known FUS mutation by whole-exome sequencing and targeted evaluation for mutations in other known ALS genes followed by genotype–phenotype correlation analysis of FUS/TBK1 double-mutant patients. We report on new and summarize previously published FUS and TBK1 double-mutant ALS/FTD patients and their families. We found that, within a family, mutations in FUS cause ALS while TBK1 single mutations are observed in FTD patients. FUS/TBK1 double mutations manifested as ALS and without a manifest difference regarding age at onset and disease duration when compared to FUS single-mutant individuals. In conclusion, TBK1 and FUS variants do not seem to interact in a simple additive way. Rather, the phenotype of FUS/TBK1 double-mutant patients appears to be dominated by the FUS mutation.
Maternal C-reactive protein concentrations during pregnancy and birth weight in a prospective cohort in Rio de Janeiro, Brazil
Creators: name: Oliveira, Livia Costa De
name: Franco-Sena, Ana Beatriz
name: Farias, Dayana Rodrigues
name: Rebelo, Fernanda
name: Kac, Gilberto
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Objective: To evaluate the association between maternal C-reactive protein (CRP) concentrations during pregnancy and birth weight (BW) Z-score. Methods: A prospective cohort of pregnant women were followed at 5–13 (n = 203), 20–26 (n = 181), and 30–36 (n = 181) gestational weeks and at 30–45 d postpartum. Maternal CRP concentrations were assessed three times during pregnancy using immunoturbidimetric methods (ultra-sensitive kits). BW Z-score and newborns classified as small for gestational age (SGA) were evaluated according to Intergrowth-21st curves. Statistical analyses included SGA rates, BW Z-score means (SD) and a two-stage procedure: (1) a linear mixed-effect model (LME) to predict CRP intercept (mean exposure level) and slope (trend of change during pregnancy); and (2) a multiple linear regression model with BW Z-score as the outcome and CRP intercept and slope exposures. Results: A total of 4.4% (n = 9) women delivered SGA newborns. The mean BW was 3282.0 (37.3) g, and the mean gestational age at delivery was 38.8 (0.1) weeks. Women in the third tertile of the CRP rate of change gave birth to infants with a mean BW Z-score that was lower than those in the first/second tertiles (0.226 versus 0.381; p = 0.324). For the adjusted baseline CRP (β = 0.08; 95% CI: 0.03–0.14), the CRP trend of change was inversely associated with the BW Z-score (β= −3.77; 95% CI: −5.45 to −2.10). Conclusions: The maternal CRP trend of change during pregnancy was negatively associated with BW Z-score.
Restart strategies in a continuous setting
Creators: name: Lorenz, Jan-Hendrik
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Restarts
subject: Universal strategy
subject: Randomized algorithm
subject: DDC 000 / Computer science, information & general works
subject: Computer algorithms
subject: Algorithmus

description: Restarting is a technique frequently employed in randomized algorithms. After some number of computation steps, the state of the algorithm is reinitialized with a new, independent random seed. Luby et al. (Inf. Process. Lett. 47(4), 173–180, 1993) introduced a universal restart strategy. They showed that their strategy is an optimal universal strategy in the worst case. However, the optimality result has only been shown for discrete processes. In this work, it is shown that their result does not translate into a continuous setting. Furthermore, we show that there are no (asymptotically) optimal strategies in a continuous setting. Nevertheless, we obtain an optimal universal strategy on a restricted class of continuous probability distributions. Furthermore, as a side result, we show that the expected value under restarts for the lognormal distribution tends towards 0. Finally, the results are illustrated using simulations.
High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of adolescent pulmonary tuberculosis
Creators: name: Geweniger, Anne
name: Janda, Ales
name: Eder, Kristin
name: Fressle, Roland
name: Kannan, Cecil Varna
name: Fahnenstich, Hubert
name: Elze, Mirjam
name: Müller, Christoph
name: Henneke, Philipp
name: Hufnagel, Markus
name: Elling, Roland
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Tuberculosis
subject: Diagnostics
subject: Children
subject: Adolescents
subject: Refugee minor
subject: Unaccompanied
subject: Migrants
subject: Refugees
subject: Mediastinal lymphadenopathy
subject: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
subject: EUS-B-FNA
subject: INTRATHORACIC TUBERCULOSIS
subject: MTB/RIF
subject: SAFETY
subject: DDC 610 / Medicine & health

description: Abstract Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found useful for the evaluation of mediastinal pathologies in adults, for children, sparse data are available. Here, we have evaluated EBUS-TBNA as a diagnostic procedure in children and adolescents with suspected pulmonary Tb. Methods In this retrospective analysis, we reviewed the charts of unaccompanied refugee minors (URM) who were admitted between January 2016 and July 2018 and who, during their initial medical screening upon arrival in Germany, were found to have abnormal radiological pulmonary and mediastinal findings and/or immunological results indicative of Tb. For each patient, basic sociodemographic data, clinical features and data on diagnostic procedures performed were assessed. These included imaging, immunodiagnostic tests and microbiological data derived from sputum, bronchoalveolar lavage, EBUS-TBNA, bronchoscopy and pleural fluid sampling. All patients who underwent invasive sampling procedures were included in the study. Results Out of 42 URM with suspected Tb, 34 fulfilled the study’s inclusion criteria. Ages ranged from 14 to 17 years. All were of African origin, with 70.0% coming from Somalia, Eritrea and Ethiopia. Among the 21 patients for whom EBUS-TBNA was performed, the diagnostic yield was high: 66.7% positive results (MTb detected either by acid-fast stain, culture or PCR in 4.8, 42.9 and 61.9% of samples, respectively). Multidrug-resistant MTb was found in two patients from Somalia. No complications were associated with the procedure. Overall, pulmonary Tb was diagnosed in 29 patients (85.3%), miliary Tb in two patients (5.9%) and latent Tb in three patients (8.8%). Conclusions EBUS-TBNA is a sensitive and safe method with high diagnostic yield in the evaluation of pediatric patients with mediastinal pathology and suspected Tb.
The causal structure of the effort-reward imbalance model and sbsenteeism in a cohort study of German employees
Creators: name: Montano, Diego
name: Peter, Richard
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Sick leave
subject: Work stress
subject: Cohort study
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Sick leave
subject: Absenteeism
subject: Workplace
subject: Stress, Psychological
subject: Cohort studies
subject: Fehlzeit
subject: Arbeitsplatz
subject: Stress

description: The present study contributes to previous research by assessing the validity of the causal structure of the Effort-Reward Imbalance model in relation to the psychosocial mechanisms involved in sickness absenteeism. To this end, data from the German Cohort Study on Work, Age, Health and Work Participation are analysed (lidA Study, n = 6,270). The main hypotheses concerning short- and long-term sick-leave rates are investigated with six hurdle regression models. The results suggest that a high effort-reward imbalance, and high efforts and low rewards at work are associated with an increasing likelihood of sick leave. However, the combination of high effort-reward imbalance and high overcommitment was associated with lower sick-leave rates, in contradiction to the hypothesis postulating cumulative adverse effects of increased effort-reward imbalance and high overcommitment on health-related outcomes. Long-term sick-leave rates among workers of higher occupational and educational status were substantially lower in comparison to those among workers of lower status categories. Even though most hypotheses of the Effort-Reward Imbalance model are suitable for explaining the patterns of absenteeism in this sample, the results point to more complex motivational processes and socioeconomic characteristics of employees moderating and mediating the associations between perceived efforts and rewards at work and absenteeism.
title: OFROM: interview avec unine15a47m
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.ffad5y84.v2#0d7021da204f79c7ef65698408073c47755f4d7c
Technocratic attitudes: a citizens’ perspective of expert decision-making
Creators: name: Bertsou, Eri
name: Pastorella, Giulia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Despite repeated appointments of technocratic governments in Europe and increasing interest in technocracy, there is little knowledge regarding citizens’ attitudes towards technocracy and the idea of governance by unelected experts. This article revisits normative debates and hypothesises that technocracy and democracy stand in a negative relationship in the eyes of European citizens. It tests this alongside a series of hypotheses on technocratic attitudes combining country-level institutional characteristics with individual survey data. While findings confirm that individual beliefs about the merits of democracy influence technocratic attitudes, two additional important factors are also identified: first, levels of trust in current representative political institutions also motivate technocratic preferences; second, historical legacies, in terms of past party-based authoritarian regime experience, can explain significant cross-national variation. The implications of the findings are discussed in the broader context of citizen orientations towards government, elitism and the mounting challenges facing representative democracy.
Emergence of Proto-Communication using Action  Primitives Symbolized in Recurrent Q-Learning Agents
Creators: name: Sato, Takashi
Publisher: name: Applied Science and Computer Science Publications
Year: 2016

description: Abstract: In this paper, we suppose the gesture theory that is one of the theories on the origin of language, which tries to establish that the speech originated from gestures. Based on the theory, we assume that “actions” having some purposes can be used as “symbols” in the communication through a learning process. The purpose of this study is to clarify what abilities of agents are necessary to acquire usages of the actions as the symbols. To achieve the purpose, we adopt a collision avoidance game and recurrent Q-learning (RQL) agents as the game players. Our simulations showed that the RQL agents can emerge a proto-communication to avoid collision with opponent by using visual information that the opponent turns its own eye away from the agent through the learning process. Further, we found that the RQL agents also obtain a rotational behavior to avoid collision by expanding the maximum number of learning iteration
Optimization of a protocol for soil analysis through mass spectrometry-based proteomics and taxonomic and functional analysis of microbial communities to assess soil health status
Creators: name: Silvio Scarciglia
Publisher: name: Zenodo
Year: 2025
Subjects: Metaproteomics, Soil Health, Soil Microbial Communities, Mass Spectrometry, Antibiotic Resistance Genes (ARGs), Agricultural Soils, Soil Protein Extraction, LC-MS/MS, Environmental Microbiology

description: Soil microbial communities are crucial indicators of soil health and are deeply influenced by agricultural practices. This thesis, developed within an Erasmus traineeship at the University of Greifswald (Germany), aimed to optimize a protocol for soil protein extraction to support mass spectrometry-based metaproteomic analyses. Different extraction protocols were tested and compared on agricultural soil samples to maximize protein yield and identification reliability. Taxonomic and functional analyses, particularly focusing on antibiotic resistance genes (ARGs), were carried out to assess microbial community composition and soil health. Results demonstrate that protocols B and B2 provided the best performance in terms of reproducibility and depth of proteome coverage. The findings contribute to the methodological advancement of soil metaproteomics and provide useful tools for future studies on soil quality assessment.
The Roman Site on Grey Hill, Bewcastle, Cumbria.
Creators: name: Woolliscroft, David J
name: Nevell, Michael D
name: Swain, S A M
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 89, 69-76
description: A two-phase rectangular mound appears to be civil, not a signal station; Phase I ended in destruction.
Fieldwalking in the Solway Plain, 1983-84.
Creators: name: Caruana, Ian D
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 89, 51-68
description: The search was for dating evidence relating to cropmark sites such as Sandybrow in Westward parish, which produced Roman material. Also noted was a prehistoric flint and axe scatter along the Caldew terrace.
Influence of light on the biosynthesis of ophiobolin A by Bipolaris maydis
Creators: name: Fanelli, Francesca
name: Reveglia, Pierluigi
name: Masi, Marco
name: Mulè, Giuseppina
name: Zonno, Maria Chiara
name: Cimmino, Alessio
name: Vurro, Maurizio
name: Evidente, Antonio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry
subject: Plant Biology

description: Ophiobolin A (O-A) is a sesterpenoid with numerous biological activities, including potential anticancer effects. Its production at an industrial level is hampered due to inability of fungus Bipolaris maydis to biosynthesise it in vitro in large amount. Among the environmental factors regulating fungal metabolism, light plays a crucial role. In this study, the use of different light wavelength (light emitting diodes (LEDs)) was evaluated to increase the O-A production. The white light allowed the highest production of the metabolite. The blue and green lights showed an inhibitory effect, reducing the production to 50%, as well as red and yellow but at a lower level. No correlation between fungal growth and metabolite production was found in relation to the light type. A novel application of LED technologies, which can be optimised to foster specific pathways and promote the production of metabolites having scientific and industrial interest was proposed.
A General Access Route to High‐Nuclearity, Metal‐Functionalized Molecular Vanadium Oxides
Creators: name: Greiner, Simon
name: Hettig, Jan
name: Laws, Alec
name: Baumgärtner, Katharina
name: Bustos, Jenna
name: Pöppler, Ann‐Christin
name: Clark, Adam H.
name: Nyman, May
name: Streb, Carsten
name: Anjass, Montaha
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Supramolecular
subject: Synthesis
subject: DDC 540 / Chemistry & allied sciences
subject: Polyoxometalates
subject: Self-assembly (Chemistry)
subject: Vanadium oxide
subject: Polyoxometallate
subject: Selbstorganisation
subject: Supramolekulare Chemie
subject: Synthese

description: Molecular metal oxides are key materials in diverse fields like energy storage and conversion, molecular magnetism and as model systems for solid-state metal oxides. To improve their performance and increase the variety of accessible motifs, new synthetic approaches are necessary. Herein, we report a universal, new precursor to access different metal-functionalized polyoxovanadate (POV) clusters. The precursor is synthesized by a novel solid-state thermal treatment procedure. Solution-phase test reactions at room temperature and pressure show that reaction of the precursor with various metal nitrate salts gives access to a range of metal-functionalized POVs. The first nitrate-templated molecular calcium vanadate cluster is reported. We show that this precursor could open new access routes to POV components for molecular magnetism, energy technologies or catalysis.
Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells
Creators: name: Qinghe Han
name: Haiyu Wang
name: Xiao, Chong
name: Ben-Dong Fu
name: Chong-Tao Du
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A signiﬁcantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H2O2-induced oxidative stress.
Cognitive Product Tracking Sensor
Creators: name: Arteaga, Asier
Publisher: name: Zenodo
Year: 2022
Subjects: Steel Manufacturing
Cognitive Sensor
Industry 4.0
Automation
Process Industry
Innovation
H2020

description: The final product of steel long producers are bars of different composition, size and length. As the process is discontinuous and the product varies in form, size and number during the whole production operation, the detailed tracking of the final bar and link to the detailed data collected at different moments is a challenging issue. In fact, the amount of data is also very variable, from the liquid steel as one unit, to the intermediate product (a billet) in units of tens up to the final bars in units of hundreds
description: https://www.capri-project.com
description: {"references": ["https://doi.org/10.5281/zenodo.6451857"]}
title: OFROM: interview avec unine15a43d
Creators: name: Delafontaine, François
name: Legrand, Camille
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.5e01j3zy.v2#0fe25bc309f833d6b15f880445b501cc96a6bd63
Hadrian's Wall: the forts at Drumburgh.
Creators: name: Bellhouse, Richard L
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 89, 33-36
description: New observations on the Kirkbride fort, the Turf Wall, Drumburgh fort, and Fingland Rigg.
Interim results of survey work on Stockdale Moor and Town Bank, West Cumbria.
Creators: name: Quartermaine, Jamie A
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 89, 25-32
description: 1730 monuments were found in twenty-three cairnfields/field systems, with strong differences between the two areas.
Isolation of a new compound, 2-butanone 4-glucopyranoside 6′-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb
Creators: name: Somsak Nualkaew
name: Thongpraditchote, Suchitra
name: Yuwadee Wongkrajang
name: Umehara, Kaoru
name: Noguchi, Hiroshi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Plant Biology

description: This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6′-O-gallate (1) with eight known compounds, namely, 3,3′-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)–dihydromyricetin-4′-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9). All compounds were isolated for the first time from this plant. The major compounds (2, 3 and 5) exhibited significant anti-inflammatory activity. In conclusion, M. edule was recognised to be a good source for phenolic compounds and these compounds may contribute to anti-inflammatory activity of the extract.
Two Newly Discovered Cup and Ring Marked Stones from Penrith and Hallbankgate, with a Gazetteer of all known Megalithic Carvings in Cumbria.
Creators: name: Frodsham, Paul N K
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 89, 1-20
Non-visual homing and the current status of navigation in scorpions
Creators: name: Prévost, Emily Danielle
name: Stemme, Torben
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Path integration
subject: Home vector
subject: Chelicerata
subject: Spatial cognition
subject: Mechanosensation
subject: DDC 570 / Life sciences
subject: DDC 590 / Animals (Zoology)
subject: Proprioception
subject: Propriozeption
subject: Fühlerlose

description: Within arthropods, the investigation of navigational aspects including homing abilities has mainly focused on insect representatives, while other arthropod taxa have largely been ignored. As such, scorpions are rather underrepresented concerning behavioral studies for reasons such as low participation rates and motivational difficulties. Here, we review the sensory abilities of scorpions related to navigation. Furthermore, we present an improved laboratory setup to shed light on navigational abilities in general and homing behavior in particular. We tracked directed movements towards home shelters of the lesser Asian scorpion Mesobuthus eupeus to give a detailed description of their departure and return movements. To do so, we analyzed the departure and return angles as well as measures of directness like directional deviation, lateral displacement, and straightness indices. We compared these parameters under different light conditions and with blinded scorpions. The motivation of scorpions to leave their shelter depends strongly upon the light condition and the starting time of the experiment; highest participation rates were achieved with infrared conditions or blinded scorpions, and close to dusk. Naïve scorpions are capable of returning to a shelter object in a manner that is directionally consistent with the home vector. The first-occurring homing bouts are characterized by paths consisting of turns about 10 cm to either side of the straightest home path and a distance efficiency of roughly three-quarters of the maximum efficiency. Our results show that neither chemosensation nor vision, but rather path integration based on proprioception, plays a superior role in the homing of scorpions.
Seizures associated with antibodies against cell surface antigens are acute symptomatic and not indicative of epilepsy: insights from long-term data
Creators: name: Rada, Anna
name: Birnbacher, Robert
name: Gobbi, Claudio
name: Kurthen, Martin
name: Ludolph, Albert
name: Naumann, Markus
name: Neirich, Ulrike
name: Von Oertzen, Tim J.
name: Ransmayr, Gerhard
name: Riepe, Matthias
name: Schimmel, Mareike
name: Schwartz, Oliver
name: Surges, Rainer
name: Bien, Christian G.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Autoimmune encephalitis
subject: Neural antibodies
subject: Acute symptomatic seizures
subject: Epilepsy
subject: Long-term course
subject: DDC 610 / Medicine & health

description: Abstract Background Clinicians have questioned whether any disorder involving seizures and neural antibodies should be called “(auto)immune epilepsy.” The concept of “acute symptomatic seizures” may be more applicable in cases with antibodies against neural cell surface antigens. We aimed at determining the probability of achieving seizure-freedom, the use of anti-seizure medication (ASM), and immunotherapy in patients with either constellation. As a potential pathophysiological correlate, we analyzed antibody titer courses. Methods Retrospective cohort study of 39 patients with seizures and neural antibodies, follow-up ≥ 3 years. Results Patients had surface antibodies against the N-methyl-d-aspartate receptor (NMDAR, n = 6), leucine-rich glioma inactivated protein 1 (LGI1, n = 11), contactin-associated protein-2 (CASPR2, n = 8), or antibodies against the intracellular antigens glutamic acid decarboxylase 65 kDa (GAD65, n = 13) or Ma2 (n = 1). Patients with surface antibodies reached first seizure-freedom (88% vs. 7%, P < 0.001) and terminal seizure-freedom (80% vs. 7%, P < 0.001) more frequently. The time to first and terminal seizure-freedom and the time to freedom from ASM were shorter in the surface antibody group (Kaplan–Meier curves: P < 0.0001 for first seizure-freedom; P < 0.0001 for terminal seizure-freedom; P = 0.0042 for terminal ASM-freedom). Maximum ASM defined daily doses were higher in the groups with intracellular antibodies. Seizure-freedom was achieved after additional immunotherapy, not always accompanied by increased ASM doses. Titers of surface antibodies but not intracellular antibodies decreased over time. Conclusion Seizures with surface antibodies should mostly be considered acute symptomatic and transient and not indicative of epilepsy. This has consequences for ASM prescription and social restrictions. Antibody titers correlate with clinical courses.
title: OFROM: interview avec unine15a69m
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.6f178zwh.v2#c9f9525035bd738564f10e5d7a04e85adb41da21
title: OFROM: interview avec unine15a41m
Creators: name: Delafontaine, François
name: Legrand, Camille
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.3220nogu.v2#0231b82e2b4fe6679396508c13f7319c8d895af6
The power of solidarity: The effects of professor-librarian collaboration on students’ self-awareness of skill acquisition, pre-print and surveys
Creators: name: Gibson, Christina Taylor
name: Massey, Elizabeth Diane
Publisher: name: Maryland Shared Open Access Repository
Year: 2024
Subjects: information literacy
Threshold skills
Music
Libraries
Teaching teams

description: This is a pre-print of a paper prepared for the Communications in Information Literacy Innovative Practices section. The full texts of the surveys administered are included, although they were not included in the publication itself.
description: The Association of College and Research Libraries’ adoption of the Framework for Information Literacy in 2016 formalized a sea change in information literacy instruction. It asks librarians to instill students with the skills needed for navigating the contemporary information landscape. One way to give students sufficient practice with these skills is for librarians to encourage faculty to cover them during normal instructional time, but this has its pitfalls due to power imbalances within the academy (Franklin, 2013; Julien & Given, 2002; Lechtenberg & Donovan, 2022; Perez-Stable et al., 2022). The co-authors of this article—one a Librarian and the other an Adjunct Professor —overcame such obstacles and collaborated productively on information literacy instruction. We explore the reasons behind our success, detail the hidden labor underlying this work, describe course objectives and the structure constructed to satisfy those objectives, analyze students’ accounts of their affective journey through the course, and offer suggestions for those wishing to cultivate a similar classroom environment. Our experience indicates that instructor-librarian collaboration forged around shared histories and structured by codeveloped objectives positively influences students’ receptivity to information literacy concepts. As demonstrated by surveys of those enrolled in the course, students’ self-awareness of their own mastery increased as they applied threshold skills learned in class. Although data do not allow us to correlate academic achievement to students’ survey responses, aggregate results in both academic work and survey responses suggest that for many students these insights led to greater independence.
Cognitive sensor for blend uniformity
Creators: name: Rehrl, Jakob
name: Celikovic, Selma
name: Poms, Johannes
Publisher: name: Zenodo
Year: 2022
Subjects: Pharmaceutical Manufacturing
Industry 4.0
Cognitive Sensor
Automation
Process Industry
Innovation
H2020
Process Analytical Technology (PAT)
Raman

description: Continuous manufacturing of pharmaceutical oral dosage forms, like tablets, requires the implementation of appropriate quality control concepts. The real-time monitoring of critical quality attributes is an essential component of a quality control concept. The CPS1 solution supports prediction of the concentration of active pharmaceutical ingredients (API) in the material stream during manufacturing, using Raman spectroscopy. The availability of that information enables the development of sophisticated quality control concepts, ultimately reducing waste material and improving product quality.
description: https://www.capri-project.com
description: {"references": ["https://doi.org/10.5281/zenodo.6451793"]}
Detecting ordinal subcascades
Creators: name: Lausser, Ludwig
name: Schäfer, Lisa M.
name: Kühlwein, Silke D.
name: Kestler, Angelika M. R.
name: Kestler, Hans A.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Ordinal classification
subject: Classifier cascades
subject: Error bounds
subject: Subsets
subject: Supersets
subject: DDC 000 / Computer science, information & general works
subject: Ensemble learning (Machine learning)
subject: Maschinelles Lernen

description: Ordinal classifier cascades are constrained by a hypothesised order of the semantic class labels of a dataset. This order determines the overall structure of the decision regions in feature space. Assuming the correct order on these class labels will allow a high generalisation performance, while an incorrect one will lead to diminished results. In this way ordinal classifier systems can facilitate explorative data analysis allowing to screen for potential candidate orders of the class labels. Previously, we have shown that screening is possible for total orders of all class labels. However, as datasets might comprise samples of ordinal as well as non-ordinal classes, the assumption of a total ordering might be not appropriate. An analysis of subsets of classes is required to detect such hidden ordinal substructures. In this work, we devise a novel screening procedure for exhaustive evaluations of all order permutations of all subsets of classes by bounding the number of enumerations we have to examine. Experiments with multi-class data from diverse applications revealed ordinal substructures that generate new and support known relations.
Scientific Knowledge fit for society - Scoring scientific accuracy in climate change related news articles
Creators: name: Tremel, Constantin Sebastian
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2024
Subjects: subject: scientific accuracy
subject: climate change
subject: validation
subject: knowledge graph
subject: science communication
subject: wissenschaftliche Genauigkeit
subject: Klimawandel
subject: Validierung
subject: Wissensgraph
subject: Wissenschaftskommunikation
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: The quantity of information is increasing exponentially, and there is a vast amount of content viewed on the internet that lacks an indicator as to whether it is scientifically accurate and correct or scientifically inaccurate and incorrect. This thesis proposes the development of an indicator of scientific accuracy in online media. This should help in public debates and help in the detection of misinformation. The thesis presents a baseline score and clear interfaces for further improvement. The necessity for such a score has been validated by a user survey, and the employed methodologies were evaluated and updated through interviews with experts from the ORKG team. Furthermore, an overview of the knowledge required to conduct research in this field and a discussion for future work is provided.
description: Die Menge an Informationen nimmt exponentiell zu, und es gibt eine riesige Menge an Inhalten im Internet, für die es keinen Indikator dafür gibt, ob sie wissenschaftlich genau und korrekt oder wissenschaftlich ungenau und falsch sind. In dieser Arbeit wird die Entwicklung eines Indikators für wissenschaftliche Genauigkeit in Online- Medien vorgeschlagen. Dies sollte in öffentlichen Debatten und bei der Aufdeckung von Fehlinformationen helfen. Die Arbeit legt einen Grundstein und schafft klare Schnittstellen für weitere Verbesserungen. Die Notwendigkeit eines solchen Scores wurde durch eine Nutzerbefragung validiert, und die verwendeten Methoden wurden durch Interviews mit Experten aus dem ORKG-Team evaluiert und aktualisiert. Darüber hinaus wird ein Überblick über das für die Forschung in diesem Bereich erforderliche Wissen gegeben und eine Diskussion über künftige Arbeiten geführt.
Cognitive sensor for granule quality
Creators: name: Rehrl, Jakob
name: Celikovic, Selma
name: Poms, Johannes
Publisher: name: Zenodo
Year: 2022
Subjects: Pharmaceutical Manufacturing
Industry 4.0
Cognitive sensor
Process Industry
Automation
Innovation
H2020
Process Analytical Technology (PAT)
Particle Size Distribution

description: Continuous wet granulation is a commonly used unit operation in secondary pharmaceutical manufacturing. Its purpose is the creation of granules of well-defined size distribution. As the granule size affects critical quality attributes, real-time monitoring is of the utmost importance, reducing defective end products. The development in CPS2 provides real-time measurements of the size distribution. This data is fed to a process control concept (CPC1), which selects optimal granulation settings.
description: https://www.capri-project.com
description: {"references": ["https://doi.org/10.5281/zenodo.6451793"]}
Supplemental materials.pdf: Supplemental materials including Supplemental Figures 1-4, Supplemental Tables 1-4, captions for Supplemental Videos 1-2, and Supplemental methods. from The role of cell replacement in benthic–pelagic coupling by suspension feeders
Creators: name: Kahn, Amanda S.
name: Leys, Sally P.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Benthic–pelagic coupling through suspension feeders and their detrital pathways is integral to carbon transport in oceans. In food-poor ecosystems, however, a novel mechanism of carbon recycling has been proposed that involves direct uptake of dissolved carbon by suspension feeders followed by shedding of cells as particulate carbon. We studied cell replacement rates in a range of cold-water sponge species to determine how universal this mechanism might be. We show that cell replacement rates of feeding epithelia in explants vary from 30 h up to 7 days, and change during different seasons and life-history stages. We also found that feeding epithelia are not replaced through direct replication but instead arise from a population of stem cells that differentiate and integrate into epithelial tissues. Our results reveal a surprising amount of complexity in the control of cell processes in sponges, with cell turnover depending on environmental conditions and using stem cells as rate-limiting mechanisms. Our results also suggest that for species in cold water with high particulate organic matter, cell turnover is not the mechanism delivering carbon flux to surrounding communities.
ALS is imprinted in the chromatin accessibility of blood cells
Creators: name: Kühlwein, Julia K.
name: Ruf, Wolfgang P.
name: Kandler, Katharina
name: Witzel, Simon
name: Lang, Christina
name: Mulaw, Medhanie A.
name: Ekici, Arif B.
name: Weishaupt, Jochen H.
name: Ludolph, Albert C.
name: Grozdanov, Veselin
name: Danzer, Karin M.
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Chromatin remodeling
subject: Epigenome
subject: Integrated analysis
subject: Motor neuron disease
subject: Regulatory elements
subject: Single-nuclei sequencing
subject: Biological Sciences
subject: Medical and Health Sciences
subject: DDC 610 / Medicine & health

description: Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex and incurable neurodegenerative disorder in which genetic and epigenetic factors contribute to the pathogenesis of all forms of ALS. The interplay of genetic predisposition and environmental footprints generates epigenetic signatures in the cells of affected tissues, which then alter transcriptional programs. Epigenetic modifications that arise from genetic predisposition and systemic environmental footprints should in theory be detectable not only in affected CNS tissue but also in the periphery. Here, we identify an ALS-associated epigenetic signature (‘ epiChromALS ’) by chromatin accessibility analysis of blood cells of ALS patients. In contrast to the blood transcriptome signature, epiChromALS includes also genes that are not expressed in blood cells; it is enriched in CNS neuronal pathways and it is present in the ALS motor cortex. By combining simultaneous ATAC-seq and RNA-seq with single-cell sequencing in PBMCs and motor cortex from ALS patients, we demonstrate that epigenetic changes associated with the neurodegenerative disease can be found in the periphery, thus strongly suggesting a mechanistic link between the epigenetic regulation and disease pathogenesis. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
"Primary sources belong in a library but in a special place:” Corporate identity and user perspective on the positioning of archives in libraries.
Creators: name: Todd-Diaz, Ashley
Publisher: name: Society of American Archivists
Year: 2023
Subjects: Archives
Corporate identity
Corporate image
Libraries
Organizational structure
User study

description: This study used the theoretical framework of stakeholder theory to explore users’ perceptions of archives and how this perception impacts their use of the archives. Using an intercept survey of archives’ users actively conducting research in the reading rooms of five institutions, this study gathered data relating to how users perceive archives and libraries, their thoughts on the positioning of archives, and what they believe successful archival research looks like. Findings indicate that users value the archives and the materials they hold; however, only some users identify as archives users, and many do not acknowledge the archives beyond being a network of collections. These findings suggest users’ perceptions may be limiting their use of the resource and their potential for information-seeking success, indicating that archives have a lot of opportunity to enhance their presence and impact with users.
Automorphic Lie algebras on complex tori
Creators: name: Oelen, Casper
Publisher: name: Loughborough University
Year: 2022
Subjects: subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: An automorphic Lie algebra is a Lie algebra of certain invariants, initially arising in the theory of integrable systems, or more specifically, in the context of algebraic reduction of Lax pairs. They are defined as follows. Let a finite group Γ act on a compact Riemann surface and on a complex finite dimensional Lie algebra g, both by automorphisms. Consider the space of meromorphic maps from the Riemann surface to the Lie algebra with poles restricted to an orbit of Γ. The subspace of Γ-equivariant maps is an automorphic Lie algebra. It is an infinite dimensional Lie algebra over the complex numbers and it can be seen as a generalisation of the Onsager algebra. We lay out a classification programme for automorphic Lie algebras on complex tori and present a classification in the case of g = sl2. One of the main contributions is the construction of normal forms for automorphic Lie algebras on complex tori with g = sl2, in which case Γ is either cyclic, dihedral or the alternating group on four symbols.
title: OFROM: interview avec unine15a40d
Creators: name: Delafontaine, François
name: Ehinger, Maude
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.306a58yg.v2#603c3df9991efc21e8b5574f9d86ce73368fea82
Pain and psyche in a patient with irritable bowel syndrome: chicken or egg? A time series case report
Creators: name: Engel, Felicitas
name: Stadnitski, Tatjana
name: Stroe-Kunold, Esther
name: Berens, Sabrina
name: Schaefert, Rainer
name: Wild, Beate
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Functional gastrointestinal disorders
subject: Irritable bowel syndrome
subject: Time series analysis
subject: Case report
subject: Single case study
subject: GUT-BRAIN AXIS
subject: COPING STRATEGIES
subject: NATURAL-HISTORY
subject: SEVERITY
subject: SYMPTOMS
subject: VALIDITY
subject: DDC 610 / Medicine & health

description: Abstract Background Irritable bowel syndrome (IBS) appears to have a bidirectional interaction with both depressive and anxiety-related complaints. However, it remains unclear how exactly the psychological complaints, at the individual level, are related to somatic symptoms on a daily basis. This single case study investigates how somatic and psychological variables are temporally related in a patient with irritable bowel syndrome. Case report The patient was a woman in her mid-twenties with an IBS diagnosis. She reported frequent soft bowel movements (5–6 times per day), as well as flatulence and abdominal pain. She resembled a typical IBS patient; however, a marked feature of the patient was her high motivation for psychosomatic treatment as well as her willingness to try new strategies regarding the management of her symptoms. As an innovative approach this single case study used a longitudinal, observational, time series design. The patient answered questions regarding somatic and psychological variables daily over a period of twelve weeks with an online diary. The diary data was analysed using an autoregressive (VAR) modeling approach. Time series analyses showed that in most variables, strong same-day correlations between somatic (abdominal pain, daily impairment) and psychological time series (including coping strategies) were present. The day-lagged relationships indicated that higher values in abdominal pain on one day were predictive of higher values in the psychological variables on the following day (e.g. nervousness, tension, catastrophizing, hopelessness). The use of positive thinking as a coping strategy was helpful in reducing the pain on the following days. Conclusion In the presented case we found a high correlation between variables, with somatic symptoms temporally preceding psychological variables. In addition, for this patient, the use of positive thoughts as a coping strategy was helpful in reducing pain.