New insights into the genetic etiology of Alzheimer’s disease and related dementias
Creators: name: Bellenguez, Céline
name: Küçükali, Fahri
name: Jansen, Iris E.
name: Kleineidam, Luca
name: Moreno-Grau, Sonia
name: Amin, Najaf
name: Naj, Adam C.
name: Campos-Martin, Rafael
name: Grenier-Boley, Benjamin
name: Andrade, Victor
name: Holmans, Peter A.
name: Boland, Anne
name: Damotte, Vincent
name: Van Der Lee, Sven J.
name: Costa, Marcos R.
name: Kuulasmaa, Teemu
name: Yang, Qiong
name: De Rojas, Itziar
name: Bis, Joshua C.
name: Yaqub, Amber
name: Prokic, Ivana
name: Chapuis, Julien
name: Ahmad, Shahzad
name: Giedraitis, Vilmantas
name: Aarsland, Dag
name: Garcia-Gonzalez, Pablo
name: Abdelnour, Carla
name: Alarcón-Martín, Emilio
name: Alcolea, Daniel
name: Alegret, Montserrat
name: Alvarez, Ignacio
name: Álvarez, Victoria
name: Armstrong, Nicola J.
name: Tsolaki, Anthoula
name: Antúnez, Carmen
name: Appollonio, Ildebrando
name: Arcaro, Marina
name: Archetti, Silvana
name: Pastor, Alfonso Arias
name: Arosio, Beatrice
name: Athanasiu, Lavinia
name: Bailly, Henri
name: Banaj, Nerisa
name: Baquero, Miquel
name: Barral, Sandra
name: Beiser, Alexa
name: Pastor, Ana Belén
name: Below, Jennifer E.
name: Benchek, Penelope
name: Benussi, Luisa
name: Berr, Claudine
name: Besse, Céline
name: Bessi, Valentina
name: Binetti, Giuliano
name: Bizarro, Alessandra
name: Blesa, Rafael
name: Boada, Mercè
name: Boerwinkle, Eric
name: Borroni, Barbara
name: Boschi, Silvia
name: Bossù, Paola
name: Bråthen, Geir
name: Bressler, Jan
name: Bresner, Catherine
name: Brodaty, Henry
name: Brookes, Keeley J.
name: Brusco, Luis Ignacio
name: Buiza-Rueda, Dolores
name: Bûrger, Katharina
name: Burholt, Vanessa
name: Bush, William S.
name: Calero, Miguel
name: Cantwell, Laura B.
name: Chene, Geneviève
name: Chung, Jaeyoon
name: Cuccaro, Michael L.
name: Carracedo, Ángel
name: Cecchetti, Roberta
name: Cervera-Carles, Laura
name: Charbonnier, Camille
name: Chen, Hung-Hsin
name: Chillotti, Caterina
name: Ciccone, Simona
name: Claassen, Jurgen A. H. R.
name: Clark, Christopher
name: Conti, Elisa
name: Corma-Gómez, Anaïs
name: Costantini, Emanuele
name: Custodero, Carlo
name: Daian, Delphine
name: Dalmasso, Maria Carolina
name: Daniele, Antonio
name: Dardiotis, Efthimios
name: Dartigues, Jean-François
name: De Deyn, Peter Paul
name: De Paiva Lopes, Katia
name: De Witte, Lot D.
name: Debette, Stéphanie
name: Deckert, Jürgen
name: Del Ser, Teodoro
name: Denning, Nicola
name: DeStefano, Anita
name: Dichgans, Martin
name: Diehl-Schmid, Janine
name: Diez-Fairen, Mónica
name: Rossi, Paolo Dionigi
name: Djurovic, Srdjan
name: Duron, Emmanuelle
name: Düzel, Emrah
name: Dufouil, Carole
name: Eiriksdottir, Gudny
name: Engelborghs, Sebastiaan
name: Escott-Price, Valentina
name: Espinosa, Ana
name: Ewers, Michael
name: Faber, Kelley M.
name: Fabrizio, Tagliavini
name: Nielsen, Sune Fallgaard
name: Fardo, David W.
name: Farotti, Lucia
name: Fenoglio, Chiara
name: Fernández-Fuertes, Marta
name: Ferrari, Raffaele
name: Ferreira, Catarina B.
name: Ferri, Evelyn
name: Fin, Bertrand
name: Fischer, Peter
name: Fladby, Tormod
name: Fließbach, Klaus
name: Fongang, Bernard
name: Fornage, Myriam
name: Fortea, Juan
name: Foroud, Tatiana M.
name: Fostinelli, Silvia
name: Fox, Nick C.
name: Franco-Macías, Emlio
name: Bullido, María J.
name: Frank-García, Ana
name: Froelich, Lutz
name: Fulton-Howard, Brian
name: Galimberti, Daniela
name: García-Alberca, Jose Maria
name: García-González, Pablo
name: Garcia-Madrona, Sebastian
name: Garcia-Ribas, Guillermo
name: Ghidoni, Roberta
name: Giegling, Ina
name: Giorgio, Giaccone
name: Goate, Alison M.
name: Goldhardt, Oliver
name: Gomez-Fonseca, Duber
name: González-Pérez, Antonio
name: Graff, Caroline
name: Grande, Giulia
name: Green, Emma
name: Grimmer, Timo
name: Grünblatt, Edna
name: Grunin, Michelle
name: Gudnason, Vilmundur
name: Guetta-Baranes, Tamar
name: Haapasalo, Annakaisa
name: Hadjigeorgiou, Georgios
name: Haines, Jonathan L.
name: Hamilton-Nelson, Kara L.
name: Hampel, Harald
name: Hanon, Olivier
name: Hardy, John
name: Hartmann, Annette M.
name: Hausner, Lucrezia
name: Harwood, Janet
name: Heilmann-Heimbach, Stefanie
name: Helisalmi, Seppo
name: Heneka, Michael T.
name: Hernández, Isabel
name: Herrmann, Martin J.
name: Hoffmann, Per
name: Holmes, Clive
name: Holstege, Henne
name: Vilas, Raquel Huerto
name: Hulsman, Marc
name: Humphrey, Jack
name: Biessels, Geert Jan
name: Jian, Xueqiu
name: Johansson, Charlotte
name: Jun, Gyungah R.
name: Kastumata, Yuriko
name: Kauwe, John
name: Kehoe, Patrick G.
name: Kilander, Lena
name: Ståhlbom, Anne Kinhult
name: Kivipelto, Miia
name: Koivisto, Anne
name: Kornhuber, Johannes
name: Kosmidis, Mary H.
name: Kukull, Walter A.
name: Kuksa, Pavel P.
name: Kunkle, Brian W.
name: Kuzma, Amanda B.
name: Lage, Carmen
name: Laukka, Erika J.
name: Launer, Lenore
name: Lauria, Alessandra
name: Lee, Chien-Yueh
name: Lehtisalo, Jenni
name: Lerch, Ondrej
name: Lleó, Alberto
name: Longstreth, William
name: Lopez, Oscar
name: De Munain, Adolfo Lopez
name: Love, Seth
name: Löwemark, Malin
name: Luckcuck, Lauren
name: Lunetta, Kathryn L.
name: Ma, Yiyi
name: Macías, Juan
name: MacLeod, Catherine A.
name: Maier, Wolfgang
name: Mangialasche, Francesca
name: Spallazzi, Marco
name: Marquié, Marta
name: Marshall, Rachel
name: Martin, Eden R.
name: Montes, Angel Martín
name: Rodríguez, Carmen Martínez
name: Masullo, Carlo
name: Mayeux, Richard
name: Mead, Simon
name: Mecocci, Patrizia
name: Medina, Miguel
name: Meggy, Alun
name: Mehrabian, Shima
name: Mendoza, Silvia
name: Menéndez-González, Manuel
name: Mir, Pablo
name: Moebus, Susanne
name: Mol, Merel
name: Molina-Porcel, Laura
name: Montrreal, Laura
name: Morelli, Laura
name: Moreno, Fermin
name: Morgan, Kevin
name: Mosley, Thomas
name: Nöthen, Markus M.
name: Muchnik, Carolina
name: Mukherjee, Shubhabrata
name: Nacmias, Benedetta
name: Ngandu, Tiia
name: Nicolas, Gael
name: Nordestgaard, Børge G.
name: Olaso, Robert
name: Orellana, Adelina
name: Orsini, Michela
name: Ortega, Gemma
name: Padovani, Alessandro
name: Paolo, Caffarra
name: Papenberg, Goran
name: Parnetti, Lucilla
name: Pasquier, Florence
name: Pastor, Pau
name: Peloso, Gina
name: Pérez-Cordón, Alba
name: Pérez-Tur, Jordi
name: Pericard, Pierre
name: Peters, Oliver
name: Pijnenburg, Yolande A. L.
name: Pineda, Juan A.
name: Piñol-Ripoll, Gerard
name: Pisanu, Claudia
name: Polak, Thomas
name: Popp, Julius
name: Posthuma, Danielle
name: Priller, Josef
name: Puerta, Raquel
name: Quenez, Olivier
name: Quintela, Inés
name: Thomassen, Jesper Qvist
name: Rábano, Alberto
name: Rainero, Innocenzo
name: Rajabli, Farid
name: Ramakers, Inez
name: Real, Luis M.
name: Reinders, Marcel J. T.
name: Reitz, Christiane
name: Reyes-Dumeyer, Dolly
name: Ridge, Perry
name: Riedel-Heller, Steffi
name: Riederer, Peter
name: Roberto, Natalia
name: Rodriguez-Rodriguez, Eloy
name: Rongve, Arvid
name: Allende, Irene Rosas
name: Rosende-Roca, Maitée
name: Royo, Jose Luis
name: Rubino, Elisa
name: Rujescu, Dan
name: Sáez, María Eugenia
name: Sakka, Paraskevi
name: Saltvedt, Ingvild
name: Sanabria, Ángela
name: Sánchez-Arjona, María Bernal
name: Sanchez-Garcia, Florentino
name: Juan, Pascual Sánchez
name: Sánchez-Valle, Raquel
name: Sando, Sigrid B.
name: Sarnowski, Chloé
name: Satizabal, Claudia L.
name: Scamosci, Michela
name: Scarmeas, Nikolaos
name: Scarpini, Elio
name: Scheltens, Philip
name: Scherbaum, Norbert
name: Scherer, Martin
name: Schmid, Matthias
name: Schneider, Anja
name: Schott, Jonathan M.
name: Selbæk, Geir
name: Seripa, Davide
name: Serrano, Manuel
name: Sha, Jin
name: Shadrin, Alexey A.
name: Skrobot, Olivia
name: Slifer, Susan
name: Snijders, Gijsje J. L.
name: Soininen, Hilkka
name: Solfrizzi, Vincenzo
name: Solomon, Alina
name: Song, Yeunjoo
name: Sorbi, Sandro
name: Sotolongo-Grau, Oscar
name: Spalletta, Gianfranco
name: Spottke, Annika
name: Squassina, Alessio
name: Stordal, Eystein
name: Tartan, Juan Pablo
name: Tárraga, Lluís
name: Tesí, Niccolo
name: Thalamuthu, Anbupalam
name: Thomas, Tegos
name: Tosto, Giuseppe
name: Traykov, Latchezar
name: Tremolizzo, Lucio
name: Tybjærg-Hansen, Anne
name: Uitterlinden, Andre
name: Ullgren, Abbe
name: Ulstein, Ingun
name: Valero, Sergi
name: Valladares, Otto
name: Broeckhoven, Christine Van
name: Vance, Jeffery
name: Vardarajan, Badri N.
name: Van Der Lugt, Aad
name: Dongen, Jasper Van
name: Van Rooij, Jeroen
name: Van Swieten, John
name: Vandenberghe, Rik
name: Verhey, Frans
name: Vidal, Jean-Sébastien
name: Vogelgsang, Jonathan
name: Vyhnalek, Martin
name: Wagner, Michael
name: Wallon, David
name: Wang, Li-San
name: Wang, Ruiqi
name: Weinhold, Leonie
name: Wiltfang, Jens
name: Windle, Gill
name: Woods, Bob
name: Yannakoulia, Mary
name: Zare, Habil
name: Zhao, Yi
name: Zhang, Xiaoling
name: Zhu, Congcong
name: Zulaica, Miren
name: Farrer, Lindsay A.
name: Psaty, Bruce M.
name: Ghanbari, Mohsen
name: Raj, Towfique
name: Sachdev, Perminder
name: Mather, Karen
name: Jessen, Frank
name: Ikram, M. Arfan
name: De Mendonça, Alexandre
name: Hort, Jakub
name: Tsolaki, Magda
name: Pericak-Vance, Margaret A.
name: Amouyel, Philippe
name: Williams, Julie
name: Frikke-Schmidt, Ruth
name: Clarimon, Jordi
name: Deleuze, Jean-François
name: Rossi, Giacomina
name: Seshadri, Sudha
name: Andreassen, Ole A.
name: Ingelsson, Martin
name: Hiltunen, Mikko
name: Sleegers, Kristel
name: Schellenberg, Gerard D.
name: Van Duijn, Cornelia M.
name: Sims, Rebecca
name: Van Der Flier, Wiesje M.
name: Ruiz, Agustín
name: Ramirez, Alfredo
name: Lambert, Jean-Charles
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/692/699/375/365/1283
/631/208/205/2138
/45/43
article

description: Abstract: Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.