cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Integration of Korean Traditional Musical Elements and Daegeum Techniques into Western Flute Composition: Sori, Nong, and Un-VI
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: Isang Yun (1917–1995) was the first successful Korean-born composer in Western classical music. His students, Sukhi Kang (1934–2020) and Byungdong Paik (b. 1936), have been leading composers and educators in South Korea and both were greatly inspired by Isang Yun. All three integrated Korean traditional philosophy and musical elements with Western music composition techniques. They also adapted Korean bamboo flute performance practice and techniques into Western flute composition. The purpose of this study is to understand how these composers integrate Korean traditional musical elements and bamboo flute techniques into Western flute composition. Three pieces in particular —Sori for flute solo (1988) by Isang Yun, Nong for flute and piano (1970) by Sukhi Kang, and Un-VI for flute and piano (1981) by Byungdong Paik —all reflect Korean traditions, Korean culture, Korean music, and Korean bamboo flute techniques in a Western style of composition. Also, these three composers are interrelated: Kang and Paik are mutual friends and both studied under Yun. They were greatly influenced by him. This study begins with an introduction of the three composers, Korean music history, Korean bamboo flute, and Korean philosophical traditions. It then analyzes the previously mentioned works: Sori for flute solo (1988) by Isang Yun, Nong for flute and piano (1970) by Sukhi Kang, and Un-VI for flute and piano (1981) by Byungdong Paik.
[Wu jing] : [wu zhong, shi qi juan] [volume 17]
[五經] : [五種十七卷] [第十七冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
Exploring the potential mechanism of Aralia chinensis L. saponins in treating gastric ulcers based on UPLC-Q-Exactive-MS/MS method combined with network pharmacology
Creators: name: Shu, Yongjia
name: Chai, Huifang
name: Xie, Chengshi
name: Zeng, Miao
name: Liu, Min
name: Wang, Danli
name: Xue, Juan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study explores the active components and mechanisms of Aralia chinensis L. saponins in treating gastric ulcers based on UPLC-Q-Exactive-MS/MS technology and network pharmacology. Fifty-four chemical components were identified through UPLC-Q-Exactive-MS/MS, and 14 active components were screened. Swiss ADME and Swiss Target Prediction were utilised to determine the component targets, and the intersection with disease targets yielded 35 core targets. GO functional enrichment and KEGG pathway analysis were conducted using DAVID 2021, generating 181 entries and 36 pathways, respectively. Molecular docking results demonstrated good binding activity between the components and target proteins. The study indicates that Saponins from Aralia chinensis L. primarily act on core targets such as PTGS2, ESR1, and STAT3 through components like Cucurbitacin D and Cucurbitacin E, regulating signalling pathways such as Serotonergic synapse and Pathways in cancer, thereby exerting therapeutic effects on gastric ulcers.
Predicting structure-property relationships to accelerate chiral organic electronic materials discovery
Creators: name: Schmidt, Julia Alexandra
Publisher: name: Imperial College London
Year: 2021

description: Molecular materials are challenging to design from scratch since the packing arrangements are based on a balance of the interplay of subtle soft intermolecular interactions. The specific packing arrangement a molecular material adopts determines its properties. Rational material design aims to create new materials with tailored properties (e.g. charge-carrier mobility) but is hampered by the difficulty to predict the most stable solid-state structure for a given molecule theoretically and to obtain it experimentally. Once the structure prediction problem is resolved, structure-property relationships for each polymorph can be obtained. This thesis predicts structure-property relationships of helicenes to assesses their organic semiconductor (OSC) suitability. First, two 2,2'-disubstituted [6]helicenes were computationally predicted to investigate the structure-property relationship of functionalised [6]helicenes arranging in (homo)chiral columns. The crystal structure prediction (CSP) results were analysed with respect to the accuracy of the methodology, the (dis)similarity of the crystal packing arrangements obtained across the CSP landscapes, and its charge transport properties. Second, a dimer-based screening approach to assess the suitability of ~1,300 of terminally substituted [6]helicenes for their suitability as n-type OSC was developed and the screening results are presented. By applying CSP to the most promising molecules, the presence of the dimer motif used at the screening stage was confirmed. Furthermore, fluorination significantly improved electron transport in the molecular crystal by up to 200%, while side groups containing triple bonds largely lead to improved transfer integrals. Finally, CSP was performed for naphthalene and helicenes of varying helicene length n (n = 3-12). Thousands of crystal structures were assessed for their degree of π-π, C-H··π stacking and the degree of parallel alignment of the long helical axes. It is found that helicenes more frequently arrange in parallel to each other as the helicene length n increases, supposedly enhancing the formation of homochiral columnar packing arrangements.
title: Machine learning Models for Quality of Children’s Lives
Creators: name: Teh, Bloti
name: Kittisupakorn, Srisuda
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Machine learning
subject: Children
subject: Gerrymandering

description: Electoral system design is a key component of a democratic regime. The design of an electoral system may increase the driving force of political change. If the electoral system does not go well, it will lead to a deterioration of democracy or political stability. Gerrymandering is the one factor of unfair political advantage of the electoral system. This is not a new problem in the United States. Due to irregularity of legislative district shapes for election, majority of Americans are concerned about unfairness of political polarization affecting their quality of life especially in Texas where the high rank state of gerrymandering problem in the United States is. As the results, gerrymandering in Texas affects quality of life in terms of material welfare (according to GNP), health and political stability and safety.
title: Newspaper clipping: "UVa Center Helps Managers Work Together," June 21, 1982
Creators: name: Ravo, Nick
Publisher: name: The Daily Progress, Charlottesville, VA
Year: 1982
Subjects: subject: Warfield, John N.
subject: University of Virginia
subject: Center for Interactive Management (CIM)
subject: Demosophia

description: Newspaper article, 10" x 5" (25.4 cm x 12.7 cm)
description: Article in newspaper discussing the mission of the Center for Interactive Management and the newly built "demosophia" (situation) room. The Center was established to help facilitate decision making in groups dealing with complexity. John N. Warfield Collection 3.6
title: Newspaper Column: Give Governors a Shot at Two Terms
Creators: name: Nicoson, William J.
Publisher: name: Reston Times
Year: 2003
Subjects: subject: General Assembly (VA)
subject: Term limits
subject: Warner, Mark (Governor, VA)

description: PDF file distilled from original WordPerfect document. Original size 11" x 8.5".
description: The legislative session of the Virginia General Assembly which ended February 23 will be remembered not for what it accomplished but for what it failed to accomplish. In an election year, politicians tend to turn timorous. But for Republicans, with majorities in both houses, the irony is that the lack of focused performance at this session will be a major negative factor in their performance at the polls later this year.
title: 43.16
Creators: name: Boss, Christopher
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Track and field
subject: Clive
subject: Fischer-Kersey
subject: 400 meters
subject: Sprint

description: This thesis has been embargoed for 10 years and will not be available until April 2029 at the earliest.
description: Clive Fischer-Kersey is an elite runner who qualifies for the Olympic Games in the 400m sprint. This novel explores the psychological and social pressures that contribute to the life of a world-class athlete.
title: Redefining Race: Virginia’s Racial Integrity Act and American Indian Identification
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Indians of North America
subject: Law and legislation
subject: Virginia Act to Preserve Racial Integrity
subject: Virginia History
subject: History
subject: American history
subject: Native American studies

description: This dissertation explores the Virginia Racial Integrity Act of 1924 and the fight of American Indian against this act. It examines how the Anglo-Saxon Clubs of America, a Virginia-based white supremacist organization, succeeded in enacting the Racial Integrity Act of 1924 and thus revised the definition of “race” to maintain white supremacy. This law, for the first time, established a legal definition of a white person as one “who has no trace whatsoever of any blood other than Caucasian.” The purpose of the law was to prohibit intermarriage between whites and non-whites and to protect the “whiteness” of the race. I focus on how a law created primarily to maintain white supremacy over African Americans unexpectedly created a controversy about how to racially categorize Native Americans. A third racial category presented white supremacists with a difficult challenge in a society that, under the law, was strictly biracial: white and Black. I am interested in seeing how the white supremacists advanced their views and implemented the law, as well as how Indians reacted against the 1924 law and fought to claim their racial identity as Indians. While I examine the implementation of the law and the damage to Native communities, this dissertation also explores how Virginia Indians regained their racial status after the law was overturned. White supremacists’ racial campaign to eliminate Indians in Virginia made it difficult for many tribes to achieve tribal recognition and claim their independent racial status. The dissertation shows the current issues and impacts the Racial Integrity Act had on the tribes. Examining Virginia tribes’ decisions and their strategies for recognition helps illuminate the situation American Indians faced. Drawing on a variety of primary sources from the viewpoints of both white supremacists and those who challenged them, this dissertation helps develop a new interpretation of white supremacists’ racial campaign against non-whites and a discussion about racial identification of American Indians and their struggles navigating the biracial society. White supremacists’ ideology of racial purity persisted and pervaded into indigenous communities, which further escalated racial divisions inside the tribes. Indians were also compelled to redefine “race” within their tribal communities. Studying the Racial Integrity Act allows us to see how “race” has been made and “remade” in the Old Dominion in the twentieth century.
Proceedings of the 2015 international summit on fibropapillomatosis : global status, trends, and population impacts.
Creators: name: Hargrove, Stacy A.
name: Work, Thierry M.
name: Brunson, Shandell
name: Foley, Allen Michael
name: Balazs, George H.
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Pacific Islands Fisheries Science Center
Year: 2016
Subjects: subject: Sea turtles--Diseases--Research--Congresses.

description: The 2015 International Summit on Fibropapillomatosis (FP) was convened in Honolulu, Hawaii June 11-14, 2015. Scientists from around the world were invited to present results from sea turtle monitoring and research programs as they relate to the global status, trends, and population impacts of FP on green turtles. The participants engaged in discussions that resulted in the following conclusions: 1.Globally, FP has long been present in wild sea turtle populations—the earliest mention was in the late 1800s in the Florida Keys. 2.FP primarily affects medium-sized immature turtles in coastal foraging pastures. 3.Expression of FP differs across ocean basins and to some degree within basins. Turtles in the Southeast US, Caribbean, Brazil, and Australia rarely have oral tumors (inside the mouth cavity), whereas they are common and often severe in Hawaii. Internal tumors (on vital organs) occur in the Atlantic and Hawaii, but only rarely in Australia. Liver tumors are common in Florida but not in Hawaii. 4.Recovery from FP through natural processes, when the affliction is not severe, has been documented in wild populations globally. 5.FP causes reduced survivorship, but documented mortality rates in Australia and Hawaii are low. The mortality impact of FP is not currently exceeding population growth rates in some intensively monitored populations (e.g., Florida, Hawaii) as evidenced by increasing nesting trends despite the incidence of FP in immature foraging populations. 6.Pathogens, hosts, and potential disease and environmental cofactors have the capacity to change; while we are having success now, there needs to be continued monitoring to detect changes in the distribution, occurrence, and severity of the disease. 7.While we do not have clear evidence to provide the direct link, globally, the preponderance of sites with a high frequency of FP tumors are areas with some degree of degradation resulting from altered watersheds. Watershed management and responsible coastal development may be the best approach for reducing the spread and prevalence of the disease. 8.Future research efforts should employ a multi-factorial ecological approach (e.g., virology, parasitology, genetics, health, diet, habitat use, water quality, etc.) since there are likely several environmental cofactors involved in the expression of the disease, which is still thought to be caused by a herpesvirus. 9.Minimum FP data collection in new areas should include: individual identification (photo ID, PIT tags, etc.), standard measurements (length and weight), presence/absence of tumors, tumor severity, body condition, oral examination, method of capture, and effort.
title: Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection
Creators: name: Benedict, Ashwini
name: Bansal, Neha
name: Senina, Svetlana
name: Hooper, Idris
name: Lundberg, Lindsay
name: De La Fuente, Cynthia
name: Narayanan, Aarthi
name: Gutting, Bradford
name: Kehn-Hall, Kylene
Publisher: name: Frontiers
Year: 2015
Subjects: subject: Rift Valley Fever virus
subject: Raf
subject: Sorafenib
subject: Viral egress
subject: Replication
subject: FDA

description: There are currently no FDA-approved therapeutics available to treat Rift Valley fever virus (RVFV) infection. In an effort to repurpose drugs for RVFV treatment, a library of FDA-approved drugs was screened to determine their ability to inhibit RVFV. Several drugs from varying compound classes, including inhibitors of growth factor receptors, microtubule assembly/disassembly, and DNA synthesis, were found to reduce RVFV replication. The hepatocellular and renal cell carcinoma drug, sorafenib, was the most effective inhibitor, being non-toxic and demonstrating inhibition of RVFV in a cell-type and virus strain independent manner. Mechanism of action studies indicated that sorafenib targets at least two stages in the virus infectious cycle, RNA synthesis and viral egress. Computational modeling studies also support this conclusion. siRNA knockdown of Raf proteins indicated that non-classical targets of sorafenib are likely important for the replication of RVFV.
[Wu jing] : [wu zhong, shi qi juan] [volume 07]
[五經] : [五種十七卷] [第七冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
title: The Kurdish Quest for Autonomy in South-eastern Turkey: A Case Study on the Nationalistic and Economic Developments for Kurds in Turkey under the AKP Government (2002-2015)
Creators: name: Calleja, Charles
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Turkey
subject: PKK
subject: Autonomy
subject: Nationalism
subject: Economics
subject: AKP

description: This thesis describes the developments in Turkey with regards to its Kurdish Question. A case study is built using the greed or grievance approach in order to present the differences between the Kurdish minority living in South-Eastern Turkey and the Turks living in the rest of the country in terms of their economic situation and their nationalistic sentiment. This research analyses the extent to which such variables have contributed to the violence occurring between the two parties under the umbrella of the PKK, a designated terrorist group by the US, EU and Turkey, as well as the developments of the Kurdish Question in relation to these variables under the controversial AKP government. This study was conducted by means of analyzing data produced by other researchers and synthesized using various theoretical approaches in order to obtain a tangible final outcome in terms of the greed or grievance approach as presented by Paul Collier.
title: The impact of structural modeling on the creation of new perspectives in problem solving situations
Creators: name: Kapelouzos, Ioannes
Publisher: name: George Mason University
Year: 2016
Subjects: subject: Interactive management

description: Paper presented at the European Congress on System Science at Lausanne, Switzerland. 19 pages; illustrations; black and white; 27.9 cm.
description: A system of process management known as Interactive Management (IM) is a major component of an emerging science of generic design. It facilitates the management of complexity through the participative building of structural models by groups. Data from applications of IM are presented which support the hypothesis that the process of structural modeling enables group members to appreciate and conceptualize new perspectives on the problematic situation. A case is also presented that illuminates this hypothesis.
title: Concentration of Metals in Alzheimer’s Disease Plaques
Creators: name: Pruett, John
Publisher: name: George Mason University
Year: 2015
Subjects: subject: Alzheimer's disease
subject: Tg2576 mouse
subject: Amyloid plaque
subject: Trace metals in drinking water

description: Alzheimer’s disease (AD) is the most common form of dementia in the world. This study focused on the effects of how different metals added to drinking water affected the metal concentrations in the plaques. There is disagreement in the field about some of the underlying mechanisms in relation to trace metals where concern is if these trace metals are harmful or beneficial. It was hypothesized that adding trace metals to drinking water would have a significant effect on the metal concentration of the amyloid plaque. This study examined the metal concentrations in the plaques in the Tg2576 mouse brain raised on 4 different types of waters, specifically with different metals added to the water, in addition to a lab water group. Mice were raised on water treatments from 3-14 months postnatal. They were broken up into four groups reflective of the metal added to the water: 10ppm ZnCO3 (Zinc carbonate), 10ppm of ZnCO3 & 0.25ppm CuCO3 (Zinc & Copper carbonate), 10ppm of Fe(NO3)3 (Iron nitrate), and unspiked (tap) lab water. Data were collected from spectroscopes at National Synchrotron Light Source at Brookhaven National Labs using the electron beam at X27a, while analysis was conducted at George Mason University. This study found water treated with various trace metals was significantly different among zinc and iron metal levels in the amyloid plaque, but came back non-significant for copper metal. The results of this study support that the trace metals added to the drinking to Tg2576 mice does have an effect on amyloid metal concentration. There is a limited amount of research focused solely on the amyloid plaque and the effects of trace metals in drinking water. This study adds to the complex dynamic of Alzheimer’s disease by adding further the behavior of the amyloid plaque when exposed to different types of water.
title: Rooftops to Rice Paddies: Aerial Utopianism, Helicopters, and the Creation of the National Security State
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: This thesis describes the social construction of rotorcraft technology in the United States through the lens of the industry’s largest customer, the military, which provides a counternarrative to the deterministic inventor-entrepreneur accounts of rotary-wing development. The author argues that, as the federal state expanded rapidly between the New Deal and the Vietnam War, short-range aerial mobility (“vertical flight”) became central to new conceptions of American power, both at home and abroad. During the 1930s and ‘40s, the helicopter and its rotary-wing antecedent, the Autogiro, featured in the popular imagination as technologically modernist responses to the challenges of movement in dynamic urban landscapes, but failed to gain enough commercial investment to sustain the emergent rotorcraft industry. Meanwhile, military officers, like H. Franklin Gregory, explored the use of vertical flight as a solution to the uncertainties of modern warfare waged over difficult geographies, and in the process, provided a solid industrial base for helicopter manufacturing. By the Cold War, despite persistent hopes that vertical flight would transform the American landscape, military imperatives overshadowed commercial development as Army and Marine Corps leaders embraced helicopter mobility as an answer to the chaos of the atomic battlefield. General James Gavin’s reconfiguration of the Army around helicopters and battlefield atomic weapons, and an expansive application of force in Cold War geographies, rapidly brought vertical flight to the forefront of American power, including as a means of domestic authority and control. The prominent rise of military vertical flight contrasted starkly with the repeated failures of civil agencies to implement urban air mobility.
Carbon–oxygen bond alumination of furans and anisoles
Creators: name: Brown, Ryan Keogh
Publisher: name: Imperial College London
Year: 2021

description: This thesis investigated the reactivity of aluminium complexes towards furans in catalysed and uncatalysed reactions that break carbon-oxygen bonds. New types of reactions are reported that form ring-expanded products with insertion of the aluminium reagent into the heterocyclic ring. It was demonstrated that the selectivity of ring-expansion could be controlled by the presence of catalytic [Pd(PCy3)2]. The mechanisms of these C–O bond cleavage reactions were probed experimentally and computationally. The uncatalysed reactions were found to operate via a two-step pathway with electronic control over selectivity. In the catalysed reactions the pathway was found to operate via initial C–H activation of furan and subsequent C–O activation by a heterobimetallic Pd–Al complex. In addition, the reactivity of a low-valent aluminium complex with anisoles was investigated. Both palladium catalysed and uncatalysed reactions were discovered and led to either sp2 C–O or sp3 C–O bond cleavage products, respectively. The mechanism of the uncatalysed reaction was probed experimentally and computationally to reveal an SN2 mechanism that may be operating via a Lewis acid-assisted transition state, or by the potential formation of a known aluminyl anion in-situ, in a base-catalysed process. Investigations into the late-stage functionalisation of anisole derivatives relevant to pharmaceuticals were carried out. Furthermore, attempts to develop a new route to low-valent ß-diketiminate (BDI) aluminium complexes was investigated. It was shown, contrary to literature, that aluminayclopropenes can serve as “masked” sources of low valent aluminium by reversible alkyne binding. A computational study demonstrated the potential utility of this method for the generation of synthetic variants based on structural changes about the ß-diketiminate ligand. Efforts were made towards the isolation of masked low valent aluminium complexes with varied and novel BDI ligands.
title: Hamlet
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 1997
Subjects: subject: Hamlet
subject: USAE
subject: ANTA
subject: US Air Force
subject: State Department
subject: Barter Theater
subject: State Theater of Virginia
subject: Truman, Harry
subject: Symington, W. Stuart
subject: Davis, Blevins
subject: Breen, Robert
subject: Karson, Nat
subject: Derwent, Clarence
subject: MacMahon, Aline
subject: Abel, Walter
subject: Ford, Ruth
subject: Boyle, Ray

description: Playbill.
[Wu jing] : [wu zhong, shi qi juan] [volume 03]
[五經] : [五種十七卷] [第三冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
title: A Study of Thin-Film Superconducting Junctions
Creators: name: Korink, William P.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1969

description: The information presented in this paper is the result of research conducted toward the development. of a reproducible thin-film superconducting junction. The results of this experimentation and the equipment and procedures used are provided.

A qualitative explanation is given for the theory used in the derivation of the volt-ampere characteristics of thin-film superconducting junctions of metal-insulator- metal construction. This explanation entails the electron flow through the insulating layer through the use of the Fermi-Dirac and density of states functions.

The theoretical investigation is based on the BCS Theory and results in volt-ampere characteristics that agree very well with published experimental values, however, no direct verification was obtained.
[Wu jing] : [wu zhong, shi qi juan] [volume 12]
[五經] : [五種十七卷] [第十二冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
title: Digital Campus Podcast - Episode 01 – Wikipedia: Friend or Foe?
Creators: name: Center For History And New Media
Publisher: name: George Mason University
Year: 2007

description: Originally published by the Center for History and New Media through the Digital Campus podcast (http://digitalcampus.tv). This work is licensed under a Creative Commons Attribution 3.0 United States License (http://creativecommons.org/licenses/by/3.0/us/).
description: In our inaugural podcast our feature story covers the controversy over whether Wikipedia is a useful or problematic resource for students. In the news roundup, we wonder if the launch of Windows Vista has any significance, ponder the rise of Google Docs as an alternative to Word, and cover recent stories about Blackboard‘s patents and [...]
International comparisons of surgical performance: the USA and UK
Creators: name: Murray, Alice
Publisher: name: Imperial College London
Year: 2019

description: The USA and UK have focused largely on improving standards of care according to national best practice. Yet increasingly healthcare systems are looking outwards to compare performance at an international level in the hope of answering “Are we providing the best healthcare possible? If not, how can we improve?” The majority of current international comparisons are based on a range of high-level, population-based, indicators of health system performance for example, life expectancy or vaccine uptake. The literature comparing surgery is sparse, but such specialty- level comparisons may offer novel insights into how surgical care is organized and delivered. This thesis aims to address different aspects of benchmarking surgical quality and performance between the USA and UK as a platform for understanding the broader topic of international comparisons. The apparent differences in health systems, make comparisons more challenging, but should not limit opportunities for learning. This thesis starts by systematically reviewing peer-reviewed, published comparisons of surgical performance between the USA and UK. Findings from this review provide a basis for the remaining chapters comparing surgical care from different perspectives; using administrative data to understand different international practice patterns and adoption of technology, using clinical registry data to understand technical challenges in comparisons and finally using patient medical records to outline challenges in data collection across countries. Each study highlights differences between these countries, however international benchmarking is limited by methodological complexity and must be approached judiciously, otherwise this risks misinterpretation, misdirection of efforts to improve, and failure to drive change at a policy or practice level. In conclusion, this thesis provides an outline of the opportunities and limitations of international comparisons of surgical care as well as future directions for the development of a more robust research approach, with a view to encouraging a culture of international learning and impacting genuine change.
title: Deep Learning Model to Identify Somatic Driver Mutations in Cancer
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Cancer
subject: Convolutional neural network
subject: Deep learning
subject: Driver mutations
subject: Machine learning
subject: Somatic mutations
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: Large-scale genome sequencing efforts have generated somatic mutation data across large cohorts of patients and many tumor types. This comprehensive collection of data has enabled a more complete understanding of the mutational landscape in various cancers. One of the key challenges for researchers going forward is to distinguish the pathogenic driver mutations that lead to cancer from the neutral passenger mutations that do not directly contribute to the disease phenotype. We developed a novel deep learning method that uses a convolutional neural network to model the effects of somatic mutations on protein structure and stability to identify driver mutations in cancer. The CNN model accurately identified driver and passenger mutations from large-scale sequencing projects. It outperformed traditional machine learning methods and many popular effect predictors. The model could prove to be a useful tool for researchers in the search for driver mutations that play an important role in cancer initiation and progression and might help to understand the mechanisms of oncogenesis.
[Wu jing] : [wu zhong, shi qi juan] [volume 11]
[五經] : [五種十七卷] [第十一冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
Role of Smad2/3 linker serine phosphorylation in regulating TGF-β signalling
Creators: name: Trivedi, Manjari
Publisher: name: Imperial College London
Year: 2021

description: Transforming growth factor-β (TGF-β)/activin/nodal signalling play a critical role in many physiological and pathophysiological processes such as in embryogenesis, adult tissue homeostasis as well as in disease onset and progression. They signal via heteromeric complexes of type I and type II receptors, which phosphorylate and activate downstream signal effectors- Smad2 and Smad3 (Smad2/3). Phosphorylation of the C-terminal SxS motif of Smad2/3 by the receptors induces them to form oligomeric complexes with Smad4 and accumulate in the nucleus where they regulate transcription. In addition to the SxS phosphorylation, Smad2/3 can also be phosphorylated at their linker region. Smad2/3 are comprised of two highly conserved MH1 and MH2 domains connected by an unstructured linker that contains several phosphorylatable serine and threonine residues. Specifically, there are proline-directed linker threonine (LT) and serine (LS) residues that are phosphorylated by various kinases such as PI3K/mTORC2, MAPKs, Rho/ROCK, GSK3-β, CDKs etc. to regulate Smad2/3 activity by altering their subcellular localisation, transcription, and protein stability. LT and LS are closely linked and are perceived to have similar functions in TGF-β signalling. However, a study in our lab showed that they are differentially regulated, suggesting they may also have different functions in TGF-β signalling. Therefore, this study aims to dissect the individual roles of LS and LT in regulating TGF-β signalling by using various cell models such as human embryonic stem cells (hESCs), mouse embryonic stem cells (mESCs), and PC3 cells for mechanistic and functional studies. LS was found to be phosphorylated by CDK8/9 while LT was not much affected. Inhibition of LS phosphorylation (pLS) delayed the deactivation of Smad2, resulting in their nuclear accumulation and augmented transcriptional activity. Conversely, inhibition of pLS in inactivated Smad2 after withdrawing the agonist resulted in Smad2 proteasomal degradation. These findings reveal two distinct mechanisms by which pLS can regulate TGF-β signalling, which will greatly impact our understanding of the effects of non-canonical Smad signalling on canonical TGF-β signalling and also provides potential insights into ways TGF-β responses could be manipulated for therapeutic benefits.
title: Press release: C. Harrison Mann, Jr., ca. 1967
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2005
Subjects: subject: Virginia Traffic Safety Study Commission
subject: Lynchburg Colony
subject: Lynchburg Training School and Hospital
subject: Mental institutions

description: Press release: typescript, 11" x 8.5" (27.9 cm x 21.6 cm)
description: Press release by C. Harrison Mann, Jr. regarding a Republican candidate for election, Mr. Miller, and his criticisms of the Virginia Traffic Safety Commission and mental institutions such as the Lynchburg Colony also known as the Lynchburg Training School and Hospital. C. Harrison Mann, Jr. Collection 1.31
title: Speech: C. Harrison Mann, Jr., no date
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2007
Subjects: subject: American Nazi Party

description: Speech: 5 pgs, typescript, 8.5" x 11" (21.6cm x 27.9cm)
description: Speech by C. Harrison Mann, Jr. in which he explains the reasoning behind his bill to revoke the incorporation of the American Nazi Party in Virginia. C. Harrison Mann, Jr. Collection 16.10
Supplementary document for A simple optical encryption and decryption strategy based on bilayer soft actuator and laser-induced structural color - 6282418.pdf
Creators: name: Zhang, Chenchu
name: Zhao, Qiangqiang
name: Bian, Yucheng
name: Zhao, Linhan
name: Wang, Jin
name: Zhang, Heng
name: Hu, Ying
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supporting information
title: The Purpose of Education: The Perspective of Students and Graduates
Creators: name: Rahman, Mohammed
Publisher: name: George Mason University
Year: 2020
Subjects: subject: Purpose of education
subject: College experience
subject: Values, liminality and education
subject: Education and economy
subject: Liminality and college

description: This thesis explored what goals and motivations propelled students to pursue a college education. The data was collected using semi-structured one-on-one interviews along with focus groups. The finding was then compared with the historical purposes of education. To that end, the history of the education system of the United States was examined to see how the purposes changed over time as well as to contextualize the views found in the interviews and focus groups. Cora Du Bios’s work on values helped to frame the historical context as well as point to cultural motivations for college. Victor Turner’s work on liminality helped to examine the state of anxiety that students go through as they attend college, transitioning into adulthood. This was juxtaposed with the neoliberal turn of the American economy which created a liminal state that the current college students found themselves having to navigate. Placing students in a very precarious position when they are trying to determine the best course of action for their future.
title: The LEM3 Implementation of Learnable Evolution Model and Its Testing on Complex Function Optimization Problems
Creators: name: Wojtusiak, Janusz
name: Michalski, Ryszard S.
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Evolutionary computation
subject: Learnable evolution model
subject: Function optimization
subject: Machine learning

description: © ACM, 2006. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution.
description: Learnable Evolution Model (LEM) is a form of non-Darwinian evolutionary computation that employs machine learning to guide evolutionary processes. Its main novelty are new types of operators for creating new individuals, specifically, hypothesis generation, which learns rules indicating subareas in the search space that likely contain the optimum, and hypothesis instantiation, which populates these subspaces with new individuals. This paper briefly describes the newest and most advanced implementation of learnable evolution, LEM3, its novel features, and results from its comparison with a conventional, Darwinian-type evolutionary computation program (EA), a cultural evolution algorithm (CA), and the estimation of distribution algorithm (EDA) on selected function optimization problems (with the number of variables varying up to 1000). In every experiment, LEM3 outperformed the compared programs in terms of the evaluation length (the number of fitness evaluations needed to achieve a desired solution), sometimes more than by one order of magnitude.
title: Perceptions of Legitimacy of Maps and Mapping in Conflict Resolution
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: This research examined the relationship between stakeholder perception of legitimacy of maps/mapping and conflict resolution. Evaluation of perceptions of legitimacy in maps/mapping as part of conflict resolution can manifest as questions or judgments about who has the authority or right to map, what information sources and ways of knowing are legitimate, and what map products and methods are legitimate. A theoretical framework was developed that focused on three areas of legitimacy determined to be fundamental: legitimacy of stakeholder, legitimacy of information, and legitimacy of representation. Two water-related environmental resource case studies, each involving multiple types of stakeholders (e.g., citizen, government, agriculture, environment) involved in conflict resolution working groups, were investigated and comparatively analyzed. The Delmarva case focused on a chicken litter management conflict. The Lynnhaven case dealt with a conflict concerning oyster cultivation. Research results include findings about the importance of social considerations, framing, and abundant participant input concerning their opinions, experiences, and recommendations concerning maps/mapping in conflict resolution. A particularly significant discovery was the central and defining role legitimacy of stakeholder played in both case studies. Lastly, it is hoped that this research might be useful to conflict resolution practitioners in their attempts to “level the playing field” for stakeholders in conflict resolution activities. Therefore, potential implications and recommendations are provided that might be used to guide efforts to ensure appropriate, positive perception of legitimacy of maps/mapping among stakeholders, thereby encouraging constructive engagement, key to conflict resolution success.
title: Friendship in Azeroth: a Phenomenological Study of Relationships in the Context of the Massively Multiplayer Online Role Playing Game World of Warcraft
Creators: name: Richards, Aubin
Publisher: name: George Mason University
Year: 2016
Subjects: subject: MMORPG
subject: Ethnography
subject: Phenomenology
subject: World of Warcraft
subject: Sociology of play

description: As the world moves further into the 21st century more and more of our social activities take place online. Of particular interest is the social space of Massively Multiplayer Online Role Playing Games (MMORPGs) where the interaction of participants is mediated both in terms of interacting through a computer and a game. The question arises of how relationships in this environment are formed, progress, are impacted by the social norms of the game culture and what significance they have in the lives of those who participate in them. This study aims to address this question from a phenomenological perspective focusing particularly on the perception of reality and how that mediates the relationships involved. The data was gathered several years in an ethnography on a World of Warcraft server via participant observation. The study ultimately concluded that while both the presence of a computer and a game mediated the relationships that they eventually progressed to more 'intense' (if volatile) relationships in which the actual lives of the players seeps into the virtual-world.
[Wu jing] : [wu zhong, shi qi juan] [volume 01]
[五經] : [五種十七卷] [第一冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Yi jing : san juan.
Shi jing : si juan.
Shu jing : er juan.
Li ji : liu juan.
Chun qiu : er juan.
Edition: [Xie ben]
title: Note: John A. Bell to Sherman Unger, "Issues Involved in Clearance of Title IV Regulations For Federal Register Publications Under A Notice of Proposed Rulemaking," November 22, 1969
Creators: name: Bell, John A.
Publisher: name: George Mason University
Year: 2006

description: Textual: note, copy with red pencil marks; 11” x 8.5” (27.9 cm x 21.6 cm)
description: Note from John A. Bell to Sherman Unger with an attachment entitled "Issues Involved in Clearance of Title IV Regulations For Federal Register Publications Under A Notice of Proposed Rulemaking" all dated November 22, 1969. In this note, Bell comments on Title IV of the 1968 Housing and Urban Development Act. These comments were created after discussing this section with William Nicoson and Hilbert Fefferman. Planned Community Archives Collection, 483.06
Developing Laser Assisted - Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS) as a platform for the direct analysis of faecal metabolites in gastrointestinal health and disease
Creators: name: Paizs, Petra
Publisher: name: Imperial College London
Year: 2021

description: Faecal metabolomics presents an avenue for the non-invasive study of the gastrointestinal (GI) tract, the gut microbiome, and their interactions with environmental factors (1). This thesis serves as a first step towards developing Laser Assisted - Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS) as a platform for faecal metabolomics analysis in GI disease. Faecal LA-REIMS optimisation work was carried out and yielded improved signal-to-noise ratios and a decrease in % carry-over between samples. Further, pilot work on faecal water content in LA-REIMS analysis demonstrates the importance of correcting for variable water content. A novel application of LA-REIMS imaging for the real-time mapping of metabolites in whole fresh and frozen faecal samples was developed. The results of the optimisation work were implemented in two large scale clinical datasets. In a cohort of 234 patients (control n=131, adenoma n=77, colorectal cancer n=26), LA-REIMS demonstrates the potential for accurate direct from faecal sample adenoma and colorectal cancer (CRC) detection; this could reduce the burden of unnecessary colonoscopy and optimise cancer referral pathways. In a cohort of 169 patients (Crohn’s disease n=60, Ulcerative Colitis n=60, and control n= 49), faecal LA-REIMS demonstrates moderate-to-high diagnostic accuracy for direct from sample inflammatory bowel disease (IBD) detection. Faecal LA-REIMS analysis has the potential to optimise IBD diagnostic pathways and could reduce the burden of unnecessary endoscopic, radiological, histological and laboratory investigations. This thesis presents the first study utilising optimised LA-REIMS faecal metabolomics analysis in CRC and IBD with several tentatively identified features significantly different between disease and control states. Patient-related modifiers of the faecal metabolome were investigated in both the CRC and IBD datasets. Optimised faecal LA-REIMS analysis has potential as a rapid, preparation-free screening and diagnostic technique for CRC and IBD.
Composition of the pseudomolecules of barley cv. Morex
Creators: name: IBSC
Publisher: name: e!DAL - Plant Genomics and Phenomics Research Data Repository (PGP), IPK Gatersleben, Seeland OT Gatersleben, Corrensstraße 3, 06466, Germany
Year: 2016
Subjects: barley
Hordeum vulgare
genome assembly
genome annotation
sequence resource
next-generation sequencing

description: This table in TSV format defines the composition of the pseudomolecules from BAC sequences and WGS contigs.
			Moreover, this table provides positional information such as POPSEQ genetic positions and HiC map positions and orientations of BAC overlap clusters
			as well as the order of BACs within clusters.
Assemblies of individual barley BACs before contamination removal
Creators: name: IBSC
Publisher: name: e!DAL - Plant Genomics and Phenomics Research Data Repository (PGP), IPK Gatersleben, Seeland OT Gatersleben, Corrensstraße 3, 06466, Germany
Year: 2016
Subjects: barley
Hordeum vulgare
genome assembly
genome annotation
sequence resource
next-generation sequencing

description: Individual BAC assemblies that were considered as input for the construction of the non-redundant sequence for the barley genome. This file contains only a
			single assembly for each BAC. Each contig/scaffold sequence is printed on a single line without breaks.