cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SOFT MAGNETIC MICROROBOTS FOR TARGETED DRUG DELIVERY
Creators: name: Nowrose, Nahrin
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: Microrobots have a promising prospect to be used in healthcare and bioengineering applications due to their capability to gently access small and delicate body sites. Unfortunately, traditional materials used for the fabrication of microrobots are rigid, hindering safe operation due to the transfer of high stresses to the surrounding tissue. Additionally, traditional microrobots are often not biocompatible, which threatens the health of the patient if not properly retrieved. This dissertation describes the fabrication and actuation of small-scale (several micrometers in all dimensions) magnetic robots that are soft, biocompatible, and capable of moving over smooth and corrugated surface. Soft Magnetic Micro Robots (SMµRs) can carry payloads in their porous interior and release them using external magnetic inputs. SMµRs has therefore the potential to be used in a wide range of applications—including targeted drug release and remote biosensing and bio sampling—and access a number of difficult-to-reach sites in the human body, such as intestines or blood vessels. The structure of SMµRs consist of three thin layers: Two layers of polymer with embedded magnetic particles aligned along a preferential direction. One porous layer, in between the magnetic layers, where the SMµRs can accumulate and release payloads. SMµRs are small, light in weight, and fast and inexpensive to fabricate. Moreover, the manufacturing of SMµRs is compatible with large-scale production processes, facilitating their future commercial exploitation. Using external rotating magnetic fields, the position of the SMµRs can be controlled wirelessly via tumbling locomotion. We demonstrate two types of tumbling locomotion (length-wise and side-wise) as well as the possibility to release the internal payload of the SMµRs in a discrete or continuous manner using only changes in the intensity of the external magnetic field. We studied the performance of SMµRs under a variety of environmental conditions as well as their capability of overcoming obstacles.
Drivers of airborne human-to-human pathogen transmission
Creators: name: Herfst, Sander
name: Böhringer, Michael
name: Karo, Basel
name: Lawrence, Philip
name: Lewis, Nicola S.
name: Mina, Michael J.
name: Russell, Charles J.
name: Steel, John
name: Swart, Rik L. De
name: Menge, Christian
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Airborne pathogens - either transmitted via aerosol or droplets - include a wide variety of highly infectious and dangerous microbes such as variola virus, measles virus, influenza A viruses, Mycobacterium tuberculosis, Streptococcus pneumoniae, and Bordetella pertussis. Emerging zoonotic pathogens, for example, MERS coronavirus, avian influenza viruses, Coxiella, and Francisella, would have pandemic potential were they to acquire efficient human-to-human transmissibility. Here, we synthesize insights from microbiological, medical, social, and economic sciences to provide known mechanisms of aerosolized transmissibility and identify knowledge gaps that limit emergency preparedness plans. In particular, we propose a framework of drivers facilitating human-to-human transmission with the airspace between individuals as an intermediate stage. The model is expected to enhance identification and risk assessment of novel pathogens.
Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
Creators: name: Broberg, E.
name: Hungnes, Olav
name: Schweiger, Brunhilde
name: Prosenc, Katarina
name: Daniels, R.
name: Guiomar, R.
name: Ikonen, N.
name: Kossyvakis, A.
name: Pozo, Francisco
name: Puzelli, S.
name: Thomas, I.
name: Waters, A.
name: Wiman, Å.
name: Meijer, Adam
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: Humans
subject: Adolescent
subject: Adult
subject: Aged
subject: Middle Aged
subject: Young Adult
subject: Age Distribution
subject: Europe/epidemiology
subject: Seasons
subject: Sex Distribution
subject: Sequence Analysis DNA
subject: Influenza Vaccines/administration & dosage
subject: Influenza Human/prevention & control
subject: Vaccination/statistics & numerical data
subject: Child Preschool
subject: Child
subject: RNA Viral/genetics
subject: Influenza A Virus H1N1 Subtype/genetics
subject: Influenza Human/epidemiology
subject: European Union
subject: Influenza A Virus H1N1 Subtype/immunology
subject: Influenza A Virus H1N1 Subtype/isolation & purification
subject: Influenza A Virus H3N2 Subtype/immunology
subject: Influenza A Virus H3N2 Subtype/isolation & purification
subject: Influenza Vaccines/immunology
subject: Sentinel Surveillance
subject: Hospitalization/statistics & numerical data
subject: Influenza A Virus H3N2 Subtype/genetics
subject: Hemagglutination Inhibition Tests
subject: Epidemiological Monitoring
subject: Feasibility Studies
subject: Influenza Human/virology*
subject: 610 Medizin

description: Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years)
Additional file 1 of Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities
Creators: name: Al-Madboly, Lamiaa A.
name: Yagi, Akira
name: Kabbash, Amal
name: El-Aasr, Mona A.
name: El-Morsi, Rasha M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1.
title: Le système Terre, une introduction à la composition chimique des principaux compartiments du système planétaire.
Creators: name: JAUZEIN Michel
Publisher: name: My University
Year: 2023
Subjects: subject: atmosphère
subject: hydrosphère
subject: biosphère
subject: système terre
subject: Développement durable
subject: Génération frugale
subject: Coopérations territoriales
subject: Technologies vertes
subject: Pari réparateur

description: Le système planétaire de la Terre, son cycle de l’eau et ses cycles biogéochimiques pour quelques éléments chimiques importants pour l’activité humaine industrielle (carbone, cuivre, lithium). Notre planète Terre est un système complexe dans lequel le vivant s’est développé aux interfaces entre les océans, les continents et l’atmosphère. La diversité de ces interfaces a permis l’implantation d’écosystèmes variés, composés de nombreuses espèces d’êtres vivants en relation entre elles, qui interagissent avec les milieux physiques en présence. Ces écosystèmes sont le siège de nombreux phénomènes physiques, chimiques et biologiques qui régulent les flux d’éléments chimiques, et des matières qui les contiennent, entre les différents compartiments de notre environnement. Par ailleurs, pratiquement tous les écosystèmes sont aujourd’hui anthropisés par le développement de l’humanité et de toutes les activités humaines. Ainsi, l’ensemble des cycles biogéochimiques sont modifiés, perturbés voire totalement transformés par les activités humaines. Il est intéressant de revenir sur les notions générales de chimie environnementale et sur les grandes lignes de quelques cycles déterminants, pour comprendre leur évolution possible sous la pression des activités humaines. En effet cette pression est croissante dans la période actuelle de la vie de notre Terre que l’on appelle de ce fait l’anthropocène. Ce cours a été donné en octobre 2023 lors d'un webinaire pour les enseignants Arts et Métiers.
description: Le système Terre, une introduction à la composition chimique des principaux compartiments du système planétaire. Sommaire : Introduction sur le système Terre, La lithosphère, L’hydrosphère, L’atmosphère, La biosphère, Des cycles dynamiques
description: Tous publics
description: Distanciel synchrone
sj-docx-1-jht-10.1177_10963480211032254 – Supplemental material for Transient and Persistent Cost Efficiency in Hotels in the Canary Islands
Creators: name: Pérez-Rodríguez, Jorge V.
name: Acosta-González, Eduardo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental material, sj-docx-1-jht-10.1177_10963480211032254 for Transient and Persistent Cost Efficiency in Hotels in the Canary Islands by Jorge V. Pérez-Rodríguez and Eduardo Acosta-González in Journal of Hospitality & Tourism Research
Additional file 1 of Variation in traditional knowledge of culturally important macromycete species among three indigenous communities of Oaxaca, Mexico
Creators: name: López-García, Alexanders
name: Gómez-Hernández, Marko
name: Gándara, Etelvina
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Ethnomycological questionnaire. Questionnaire used to obtain information about the biocultural importance of wild mushrooms in the studied indigenous communities.
DIETARY POTASSIUM EFFECTS ON BLOOD PRESSURE AND WHOLE-BODY RETENTION OF POTASSIUM, SODIUM, AND CALCIUM FROM A CONTROLLED FEEDING STUDY IN PRE-HYPERTENSIVE-TO-HYPERTENSIVE ADULTS
Creators: name: Stone, Michael Steven
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nutritional science

description: Potassium is an essential nutrient, that has been labeled a shortfall nutrient by recent Dietary Guidelines for Americans Advisory Committees. Increases in potassium intake have been linked to improvements in cardiovascular and other metabolic health outcomes. Blood pressure (BP) has often been cited as the primary criterion for determining potassium requirements. Hypertension (HTN), or high BP, is a primary risk factor for cardiovascular disease and other circulatory diseases. Cardiovascular disease (CVD) is responsible for the 31% of deaths worldwide. Findings from the Agency for Healthcare Research and Quality report (which informed the recently released Dietary Reference Intakes for sodium (Na) and potassium) on potassium intake and chronic disease concluded, with a moderate strength of evidence, that increasing potassium intake decreases BP, particularly among those with HTN. Although, of the 18 randomized controlled trials assessed by the AHRQ, only 4 were dietary interventions, the rest involved potassium supplementation. Observational studies also show a consistent bone benefit with increased potassium rich fruit and vegetable intakes in cohorts spanning adolescents to the elderly. In clinical trials, higher potassium intakes through supplementation have been associated with reduced urinary calcium (Ca) excretion and improvement in Ca balance. Although, similar to BP, intervention trials assessing the impact of dietary potassium on bone are lacking. Controlled feeding studies looking specifically at increases in potassium from food are sparse, leaving a large knowledge gap in the field for a nutrient with an important potential health impact. In general, little is known about whole-body potassium retention, with the few studies conducted lacking consistency and rigor in methods and design. What potassium retention means in terms of adequacy, or how higher or lower retention may influence specific health outcomes is understudied and not well understood. Utilizing a randomized, cross-over, controlled feeding clinical study with complete metabolic balance measures, our research aims to begin filling these gaps, looking specifically at the effects of potassium intake via potato sources and a potassium supplement on BP and vascular outcomes, as well as how the source of potassium may influence potassium, Na and Ca whole-body balance. This dissertation will discuss the physiology of potassium intake, how this may affect potassium, Na, and Ca retention, and in turn what influence this has on vascular and bone related health outcomes. Overall the goal of this research is to address the question: What is the importance of dietary potassium, and how can it benefit cardiovascular and skeletal health?
SIYOSIY MENEJMENTDA SIYOSIY TAHLIL KONFIGURATSIYASI
Creators: name: Mardanov Sardorbek Zafar o'g'li
Publisher: name: Zenodo
Year: 2024

description: В данной статье будет освещена конфигурация политического управления с политическим анализом, т.е. уровень фундаментального исследования н₁ и н₂ в политическом поле внутри собственных явлений, а также взаимосвязь и взаимосвязь этих определений. “Политический менеджмент + политический анализ = рациональная эффективность и результативность” доказаны научными основами.
DEVELOPMENT AND CHARACTERIZATION OF NOVEL PROBES TO ELUCIDATE THE ROLE OF UBIQUITIN C-TERMINAL HYDROLASE L1 IN CANCER BIOLOGY
Creators: name: Krabill, Aaron D
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Medicinal and biomolecular chemistry not elsewhere classified

description: Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme (DUB) that is expressed in the central nervous system under normal physiological conditions, comprising 1-5% of the total soluble tissue in the brain. Ectopic expression of UCHL1 is observed in a number of aggressive forms cancers, where increased protein levels correlate with an increased invasive phenotype, supporting UCHL1 as an oncogene. Despite this, there is a significant lack of useful probes to validate targeting UCHL1 in vivo. In this work, both small molecule inhibitors and macromolecular inhibitors of UCHL1 were designed and characterized in an effort to alleviate this issue. Few small molecule inhibitors of UCHL1 are available, with the current gold standard LDN- 57444 suffering for poor chemical stability as well as an inability to engage UCHL1 in cells. Two previously published inhibitors, MT-19 and VAEFMK, represent viable alternatives to LDN-57444. However, it was imperative to characterize these molecules in detail to confirm their utility. Using a number of approaches, it was determined that while MT-19 is a potent inhibitor of UCHL1, it suffers from non-specific toxicity and engages other proteins in the cell, making it unsuitable for use as a probe. On the other hand, a similar approach validates VAEFMK as a UCHL1-selective probe, though it suffers from low potency and requires high concentrations in cells to fully engage UCHL1. Alternatively, the high intrinsic affinity of UCHL1 for ubiquitin (Ub) provides a starting point for macromolecular inhibitor design. However, Ub interacts with many proteins, including the nearly 100 DUBs expressed in the human genome. Using the co-crystal structures of UCHL1 and UCHL3 with Ub, a number of Ub variants (UbVs) were designed in silico to leverage the difference in the Ub-interfaces of UCHL1 and UCHL3. Biochemical testing shows that selectivity towards UCHL1 was achieved, though this selectivity was lost upon conversion of the UbV into an activity- based probe (ABP). Molecular dynamics (MD) simulations provide data to rationalize why this occurs. Although much work remains to identify an inhibitor that displays suitable potency and selectivity towards UCHL1 in cells, this work sheds light the mechanistic rationale for a variety of inhibitors and will serve as a useful reference for the design of future UCHL1-selective probes.
sj-docx-1-hpq-10.1177_13591053211014597 – Financial distress and suicidal behaviour during COVID-19: Family identification attenuates the negative relationship between COVID-related financial distress and mental Ill-health
Creators: name: Stevenson, Clifford
name: Wakefield, Juliet Ruth Helen
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: sj-docx-1-hpq-10.1177_13591053211014597 for Financial distress and suicidal behaviour during COVID-19: Family identification attenuates the negative relationship between COVID-related financial distress and mental Ill-health by Clifford Stevenson and Juliet Ruth Helen Wakefield in Journal of Health Psychology
Additional file 1 of HIHISIV: a database of gene expression in HIV and SIV host immune response
Creators: name: Costa, Raquel L.
name: Gadelha, Luiz
name: D’arc, Mirela
name: Ribeiro-Alves, Marcelo
name: Robertson, David L.
name: Schwartz, Jean-Marc
name: Soares, Marcelo A.
name: Porto, Fábio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 1 includes a table of the datasets/experiments in the current HIHISIV database (v2.0).
Bio-inspired Design of a Turbine Stage
Creators: name: Juangphanich, Paht
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified

description: This dissertation presents a strategy that incorporates nature and bio-inspired shapes to redesign turbine airfoils and stator-rotor rim seal cavity.
The first objective consists of the development of tools to optimize the turbine velocity triangles and then the 3D shape using 75 parameters. Design trends that minimize loss in the stator and rotor were discussed. The second objective expands on the first by incorporating wavy structures at the leading and trailing edges as well as the suction side mimicking design features of seal whiskers and tubercles of a whale. The airfoils were optimized to maximize the efficiency of a highly loaded high-pressure turbine at positive incidence.
The last objective addressed the design of the cavity to reduce cooling massflow and protect the turbine platform. A novel strategy was proposed to assess and optimize the shape of the cavity. In an attempt to simply the problem and identify the main physical phenomena, a slice of the flow was examined by considering a purely a 2D case in the relative frame of reference. This simplification enabled the cavity to be optimized in 2D using a geometry inspired by the meandering of rivers. The optimization produced designs that reduce the heat flux in the rear rotor platform and are less sensitive towards variations in gap and cavity total pressure. The methodology was demonstrated in 3D rotating cavity and later in a full turbine stage configuration. The strategy and design tools developed in this dissertation seek to provide understanding of the effects of bio-inspired shapes on turbine blades and lay the foundation for future experimental research into cavity flows.
Spaying/castration: How, complications, pain management
Creators: name: Osborne, Ben
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024

description: Before establishing a business of spaying heifers, you must first be able to understand and explain/sell the benefits of the pro­cedure to your potential clientele. It is a good procedure to add to an existing practice, especially if you are a new grad trying to add value or it can be a solo career opportunity as this skill is one that is currently in short supply. Spaying heifers is a labor-intensive procedure that requires learned skill and technique. It is not for the faint of heart. It is very physically and emotion­ally taxing when you are first starting out. The learning curve is steep and could potentially be expensive early on.
description: American Association of Bovine Practitioners Conference Proceedings, No. 57 (2024): 2024 Recent Graduate Conference Proceedings
STRATEGIC MODIFICATIONS TO OPTIMIZE A CELL PENETRATING ANTIMICROBIAL PEPTIDE
Creators: name: Blade, Reena
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Organic chemistry not elsewhere classified
Proteins and peptides

description: Pathogenic bacteria are evolving to drug resistant strains at alarming rates. The threat posed by drug resistant bacterial infections emphasize the need to establish new antimicrobial agents. Of immediate concern regarding the dangers of antibiotic resistance is the existence of intracellular bacteria, which find refuge from bactericidal devices by hiding within mammalian cells. Unfortunately, many therapeutics, such as vancomycin, do not possess membrane penetrating abilities to achieve efficacious eradication of bacteria at the subcellular level, allowing infections to persist. In an effort to target pathogens that thrive within mammalian cells, features of cell penetrating peptides (CPPs) and antimicrobial peptides (AMPs) were combined to develop a dual action antimicrobial CPP, cationic amphiphilic polyproline helices (CAPHs). CAPHs have proven to be an effective antimicrobial agent to combat an array of both Gram negative and Gram positive bacteria. Herein, to improve CAPHs activity, we have demonstrated how the incorporation of strategic modifications has resulted in increased cell uptake, alternative subcellular locations for CAPHs, and advanced antimicrobial potency. By simultaneously extending the helical length of CAPHs while incorporating different hydrophobic groups in place of the original isobutyl moiety that compose CAPHs we have created a FL-P17-5R series of peptides with five carbon aliphatic motifs: Fl-P17-5B, Fl-P17-5C and Fl-P17-5L. Through these modifications the peptides proved to be 2 to 5-fold more efficient in accumulating in macrophage cells than parent peptide Fl-P14LRR and where able to clear intracellular pathogenic bacteria, such as Listeria, from infected macrophages by 26 to 54%. In addition to making the Fl-P17-5R series of CAPHs to potentiate CAPHs activity, modifications to the cationic moiety of CAPHs were explored. By incorporating a new cationic monomer into the CAPHs sequence, a guanylated amino proline (GAP) residue, we produced Fl-P14GAP, a CAPHs peptide with an organized cationic charge display. This modification resulted in a 5-fold increase in cell uptake and a 2 to 16-fold decrease in minimum inhibitory concentration (MIC) values against strains of enteric and ESKAPE pathogens in comparison to Fl-P14LRR. Fl-P14GAP also executed superior clearance of intracellular pathogenic bacteria that resulted in the complete eradication of a drug resistant strain of A. baumannii from infected macrophage cells. Overall, our efforts with the Fl-P17-5R series of CAPHs and Fl-P14GAP have strengthened the therapeutic potential of CAPHs in the hopes of addressing the need for novel antibiotics with the propensity to eradicate intracellular pathogens.
Additional file 2 of HIHISIV: a database of gene expression in HIV and SIV host immune response
Creators: name: Costa, Raquel L.
name: Gadelha, Luiz
name: D’arc, Mirela
name: Ribeiro-Alves, Marcelo
name: Robertson, David L.
name: Schwartz, Jean-Marc
name: Soares, Marcelo A.
name: Porto, Fábio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 2 comprises the database design and description details.
Vaccines for all stages
Creators: name: Woolums, Amelia
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024

description: There are many vaccines to select from when developing proto­cols for beef cattle operations, and no single vaccine protocol is appropriate for all operations. Thus, vaccine protocol develop­ment requires understanding of the management of each op­eration. Unfortunately, current field trials confirming efficacy of vaccines to prevent disease in “real life” settings are not com­mon, and not all protocols have been tested. Thus, development of protocols for farm or ranch use often relies on experimental challenge studies or expert opinion. When vaccination of calves in the first 3 to 4 months of life is possible, vaccines for clostrid­ial infections and respiratory viral infections are most likely to be used to limit preweaning disease. On some operations, pre­weaning vaccination may be delayed until close to weaning if the aim is to limit postweaning disease. Vaccines likely appro­priate to limit postweaning disease include those for clostridial agents, agents that cause bovine respiratory disease, and agents likely to impact fertility in replacement heifers. Other vaccines may be appropriate on a case-by-case basis. Health records in­cluding vaccine timing and occurrence of disease in vaccinated animals can be a major help to confirm efficacy of vaccine pro­tocols. Veterinarians should periodically check for new sys­tematic reviews, meta-analyses, or randomized controlled field trials testing vaccines they used, to have the best information to use when planning vaccination protocols.
description: American Association of Bovine Practitioners Conference Proceedings, No. 57 (2024): 2024 Recent Graduate Conference Proceedings
Supplemental Material, sj-docx-1-jcn-10.1177_08830738211026053 - Predictors of Neurodevelopmental Impairment After Neonatal Bacterial Meningitis
Creators: name: Haffner, Darrah N.
name: Machie, Michelle
name: Hone, Emily
name: Said, Rana R.
name: Maitre, Nathalie L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111403 Paediatrics
subject: Neuroscience

description: Supplemental Material, sj-docx-1-jcn-10.1177_08830738211026053 for Predictors of Neurodevelopmental Impairment After Neonatal Bacterial Meningitis by Darrah N. Haffner, Michelle Machie, Emily Hone, Rana R. Said and Nathalie L. Maitre in Journal of Child Neurology
HIGH-DEFINITION WIRELESS PERSONAL AREA TRACKING USING AC MAGNETIC FIELD
Creators: name: Singh, Mohit
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Electrical engineering not elsewhere classified

description: Over the past few decades, the focus of wireless communication technology has been shrinking in terms of coverage area. It started with WMAN (Wireless Metropolitan Area Network), moved to WLAN (Wireless Local Area Network) and WPAN (Wireless Personal Area Network), and is soon expected to move to WBAN (Wireless Body Area Network). Wireless positioning/location services present a perfect analogy to wireless communication services. It started with the use of GPS (Global Positioning System), is moving to Local Area Positioning System (LPS) and will be soon moving to Personal and Body Area Positioning Systems (BPS) in the future.
This thesis presents the development of a high-speed and high-accuracy wireless magnetic positioning system which can locate the position and orientation of the sensor in real-time with a sub-mm level accuracy in body area. The system consists of an antenna (transmitter) and one or multiple sensors (receivers). The sensor module consists of a tri-axis AC magnetic field sensor, an orientation sensor, a micro-controller and a communication unit. The system is robust to multi-path, low-power, low-cost and provides complete location privacy to its users. Possible implementations of this technology could be in the field of gaming, media entertainment, security, robotics, bio medical, motion-capture and home-automation. The ultra-low latency of the system and its ability to track the sensor anywhere around the antenna without occlusion makes it a perfect candidate to be used as a Virtual/Augment Reality (VR/AR) input device.
Additional file 1 of High cognitive reserve attenuates the risk of dementia associated with cardiometabolic diseases
Creators: name: Dove, Abigail
name: Yang, Wenzhe
name: Dekhtyar, Serhiy
name: Guo, Jie
name: Wang, Jiao
name: Marseglia, Anna
name: Vetrano, Davide Liborio
name: Whitmer, Rachel A.
name: Xu, Weili
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Supplementary Material 1
sj-pdf-1-tec-10.1177_02711214211031985 – Supplemental material for Sampling Engagement in Shared Reading Activities With Children With Autism Spectrum Disorder: A Generalizability Study
Creators: name: Ford, Andrea L. B.
name: Fleury, Veronica P.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-pdf-1-tec-10.1177_02711214211031985 for Sampling Engagement in Shared Reading Activities With Children With Autism Spectrum Disorder: A Generalizability Study by Andrea L. B. Ford and Veronica P. Fleury in Topics in Early Childhood Special Education
Virus Safety of Xenotransplantation: Prevalence of Porcine Circovirus 2 (PCV2) in Pigs
Creators: name: Heinze, Julian
name: Plotzki, Elena
name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: Xenotransplantation
subject: Porcine circoviruses
subject: Virus safety
subject: 610 Medizin

description: Porcine circovirus 2 (PCV2) is the causative agent of a whole series of diseases in pigs, called PCV2 diseases (PCVD). The most relevant of them is the systemic disease (PCV2-SD), formerly called post weaning multi systemic wasting syndrome (PMWS). Xenotransplantation using pig cells, tissues and organs is under development to overcome the shortage of human transplants for the treatment of tissue and organ failure. Xenotransplantation requires functional cells, tissues or organs from healthy animals and therefore the donor pigs should be free of PCV2. Selection of PCV2-free animals will also prevent transmission of the virus to the human recipient. Using a PCR method, (i) Göttingen Minipigs, which are well characterised and which were already used in pig to non-human primate xenotransplantations, (ii) newly generated Aachen Minipigs, (iii) genetically modified pigs generated for xenotransplantation, (iv) pigs from a slaughterhouse and (v) pigs from a German farm were screened for PCV2. 50% of the Aachen minipigs and 14% of Göttingen minipigs were PCV2 positive, but the animals were apparently healthy. None of the slaughterhouse animals, the farm animals and the genetically modified animals were positive for PCV2, because they had been vaccinated. The data indicate that PCV2 may be found in healthy pigs even under SPF conditions, and that vaccination is a powerful tool to prevent infection.
Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV)
Creators: name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: retroviruses
subject: gibbon ape leukemia virus
subject: koala retrovirus
subject: transspecies transmission
subject: 610 Medizin

description: Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1) is a well-known example. The gibbon ape leukaemia virus (GaLV) and koala retrovirus (KoRV), two gammaretroviruses, are also the result of a transspecies transmission, however from a still unknown host. Related retroviruses have been found in Southeast Asian mice although the sequence similarity was limited. Viruses with a higher sequence homology were isolated from Melomys burtoni, the Australian and Indonesian grassland melomys. However, only the habitats of the koalas and the grassland melomys in Australia are overlapping, indicating that the melomys virus may not be the precursor of the GaLV. Viruses closely related to GaLV/KoRV were also detected in bats. Therefore, given the fact that the habitats of the gibbons in Thailand and the koalas in Australia are far away, and that bats are able to fly over long distances, the hypothesis that retroviruses of bats are the origin of GaLV and KoRV deserves consideration. Analysis of previous transspecies transmissions of retroviruses may help to evaluate the potential of transmission of related retroviruses in the future, e.g., that of porcine endogenous retroviruses (PERVs) during xenotransplantation using pig cells, tissues or organs.
Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease
Creators: name: Hellenbrand, Wiebke
name: Koch, Judith
name: Harder, Thomas
name: Bogdan, Christian
name: Heininger, Ulrich
name: Tenenbaum, Tobias
name: Terhardt, Martin
name: Vogel, Ulrich
name: Wichmann, Ole
name: Kries, Rüdiger Von
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Germany
subject: Prevention
subject: Neisseria meningitidies
subject: Meningococcal group B vaccination
subject: Vaccination recommendation
subject: 610 Medizin

description: In December 2013 Bexsero® became available in Germany for vaccination against serogroup B meningococci (MenB). In August 2015 the German Standing Committee on Vaccination (STIKO) endorsed a recommendation for use of this vaccine in persons at increased risk of invasive meningococcal disease (IMD). This background paper summarizes the evidence underlying the recommendation. Bexsero® is based on surface protein antigens expressed by about 80 % of circulating serogroup B meningococci in Germany. The paper reviews available data on immunogenicity and safety of Bexsero® in healthy children and adolescents; data in persons with underlying illness and on the effectiveness in preventing clinical outcomes are thus far unavailable. STIKO recommends MenB vaccination for the following persons based on an individual risk assessment: (1) Persons with congenital or acquired immune deficiency or suppression. Among these, persons with terminal complement defects and properdin deficiency, including those under eculizumab therapy, are at highest risk with reported invasive meningococcal disease (IMD) incidences up 10,000-fold higher than in the general population. Persons with asplenia were estimated to have a ~ 20–30-fold increased risk of IMD, while the risk in individuals with other immune defects such as HIV infection or hypogammaglobulinaemia was estimated at no more than 5–10-fold higher than the background risk. (2) Laboratory staff with a risk of exposure to N. meningitidis aerosols, for whom an up to 271-fold increased risk for IMD has been reported. (3) Unvaccinated household (-like) contacts of a MenB IMD index case, who have a roughly 100–200-fold increased IMD risk in the year after the contact despite chemoprophylaxis. Because the risk is highest in the first 3 months and full protective immunity requires more than one dose (particularly in infants and toddlers), MenB vaccine should be administered as soon as possible following identification of the serogroup of the index case.
Supplemental Material, sj-pdf-1-smr-10.1177_00491241211014245 - Linking Input Inequality and Outcome Inequality
Creators: name: An, Weihua
name: Jasso, Guillermina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Sociology

description: Supplemental Material, sj-pdf-1-smr-10.1177_00491241211014245 for Linking Input Inequality and Outcome Inequality by Guillermina Jasso in Sociological Methods & Research
National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
Creators: name: Hauser, Andrea
name: Hofmann, Alexandra
name: Hanke, Kirsten
name: Bremer, Viviane
name: Bartmeyer, Barbara
name: Kücherer, Claudia
name: Bannert, Norbert
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p
sj-pdf-1-jso-10.1177_23971983211033772 – Supplemental material for Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways
Creators: name: Nada, Shadia
name: Kahaleh, Bashar
name: Altorok, Nezam
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-jso-10.1177_23971983211033772 for Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways by Shadia Nada, Bashar Kahaleh and Nezam Altorok in Journal of Scleroderma and Related Disorders
Additional file 1 of The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial
Creators: name: Panayi, Adriana C.
name: Heyland, Daren K.
name: Stoppe, Christian
name: Jeschke, Marc G.
name: Didzun, Oliver
name: Matar, Dany
name: Tapking, Christian
name: Palackic, Alen
name: Bliesener, Björn
name: Harhaus, Leila
name: Knoedler, Samuel
name: Haug, Valentin
name: Bigdeli, Amir K.
name: Kneser, Ulrich
name: Orgill, Dennis P.
name: Hundeshagen, Gabriel
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Additional file 1. Supplemental data tables.
Additional file 1 of Collaboration cognizance: Development of a self-assessment tool to measure intra-professional collaborative practices (IPCP) in postgraduate medical residents at tertiary care hospitals
Creators: name: Anwar, Ayesha
name: Yasmeen, Rahila
name: Khan, Rehan Ahmed
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Supplementary Material 1
Harmonizing methods for wildlife abundance estimation and pathogen detection in Europe—a questionnaire survey on three selected host-pathogen combinations
Creators: name: Sonnenburg, Jana
name: Ryser-Degiorgis, Marie-Pierre
name: Kuiken, Thijs
name: Ferroglio, Ezio
name: Ulrich, Rainer G.
name: Conraths, Franz J.
name: Gortázar, Christian
name: Staubach, Christoph
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: Europe
subject: Diagnostic methods
subject: Animal abundance
subject: Harmonization Questionnaire
subject: Wildlife
subject: 610 Medizin

description: Background: The need for wildlife health surveillance as part of disease control in wildlife, domestic animals and humans on the global level is widely recognized. However, the objectives, methods and intensity of existing wildlife health surveillance programs vary greatly among European countries, resulting in a patchwork of data that are difficult to merge and compare. This survey aimed at evaluating the need and potential for data harmonization in wildlife health in Europe. The specific objective was to collect information on methods currently used to estimate host abundance and pathogen prevalence. Questionnaires were designed to gather detailed information for three host-pathogen combinations: (1) wild boar and Aujeszky’s disease virus, (2) red fox and Echinococcus multilocularis, and (3) common vole and Francisella tularensis. Results: We received a total of 70 responses from 19 European countries. Regarding host abundance, hunting bags are currently the most widely accessible data source for widely distributed mid-sized and larger mammals such as red fox and wild boar, but we observed large differences in hunting strategies among countries as well as among different regions within countries. For small rodents, trapping is the method of choice, but practical applications vary among study sites. Laboratory procedures are already largely harmonized but information on the sampled animals is not systematically collected. Conclusions: The answers revealed that a large amount of information is available for the selected host-pathogen pairs and that in theory methods are already largely harmonized. However, the comparability of the data remains strongly compromised by local differences in the way, the methods are applied in practice. While these issues may easily be overcome for prevalence estimation, there is an urgent need to develop tools for the routine collection of host abundance data in a harmonized way. Wildlife health experts are encouraged to apply the harmonized APHAEA protocols in epidemiological studies in wildlife and to increase cooperation.
A Priori Estimates for the Homogeneous Monge-Ampère Equation on Kähler Manifolds
Creators: name: Brubaker, Katherine Ann
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Pure mathematics not elsewhere classified
Other mathematical sciences not elsewhere classified

description: This thesis investigates the existence of smooth solutions to MA(F), proving a priori estimates on the leaves of the foliation that corresponds to smooth solutions. We demonstrate that sequences of leaves of Monge-Amp`ere foliations converge to holomorphic disks.
Genome Sequence of Paracoccus contaminans LMG 29738T, Isolated from a Water Microcosm
Creators: name: Aurass, Philipp
name: Karste, Susanne
name: Trost, Eva
name: Glaeser, Stefanie P.
name: Kämpfer, Peter
name: Flieger, Antje
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: We announce here the complete genome sequence of Paracoccus contaminans LMG 29738T, which we recently isolated from a contaminated water microcosm. The genome consists of a 2.94-Mb chromosome and a 94-kb plasmid. To our knowledge, we provide the first DNA methylation analysis of a Paracoccus species.
Using AI interpretability techniques as a method for origin determination of prehistoric green phosphates
Creators: name: Sanchez-Gomez, Daniel
name: Odriozola, Carlos P
name: Garrido-Cordero, José Ángel
name: Sousa, Ana Catarina
name: Martínez Blanes, José María
Publisher: name: Zenodo
Year: 2025

description: Conference Paper at 52nd CAA International Conference - 2025 - Digital Horizons: Embracing heritage in an evolving world
Why are some people more fit than others? Correlates and determinants of cardiorespiratory fitness in adults: protocol for a systematic review
Creators: name: Perumal, Nita
name: Mensink, Gert
name: Keil, Thomas
name: Finger, Jonas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: Risk factors
subject: Determinants
subject: Cardiorespiratory fitness
subject: Aerobic fitness
subject: Systematic review
subject: Correlates
subject: 610 Medizin

description: Background: Cardiorespiratory fitness (CRF) is a physical condition that is now well established as a predictor of numerous adverse health outcomes, independent of physical activity levels. In order to be able to improve CRF at the population level and to develop effective interventions and public health programmes, it is important to understand why some people are more fit than others. Therefore, the primary aim of the systematic review described in this protocol is to examine individual and interpersonal factors that are correlated with or determine CRF among adults. Methods: The review will focus on quantitative studies that investigate any personal and interpersonal correlates and/or determinants of objectively measured CRF among the general, non-symptomatic, non-institutionalized adult population (aged 18–65 years) worldwide. The databases MEDLINE, Embase, and Cochrane Library will be searched to identify all relevant published journal articles, and Google Scholar and Scopus will be searched for grey literature. Studies where CRF is not an outcome variable and experimental studies where participants specifically receive a fitness intervention that increases CRF will be excluded. For each study, data extracted will include, among other variables, study characteristics, methodology for selecting participants into the study as well as the participants’ demographic characteristics, types of correlates and determinants of CRF investigated and their measurement methods, the objective measure of CRF used and its measurement method and validity, and the main reported results on the association between the correlates or determinants and CRF. In addition, observational studies will be assessed for methodological quality and risk of bias using a customized version of the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies by the National Heart, Lung, and Blood Institute. Experimental studies will be assessed using the 27-item Downs and Black “Checklist for Measuring Study Quality”. The final results will be presented as a narrative synthesis of the main findings of all included studies. Discussion: By consolidating and synthesizing the current research on possible individual and interpersonal correlates and determinants of CRF among adults worldwide, we aim to aid future public health actions, as well as identify gaps in our full understanding of what influences CRF.