cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A new type of intervals for solving problems involving partially defined functions
Creators: name: Filiol, Pierre
name: Bollgenier, Théotime
name: Jaulin, Luc
name: Le Lann, Jean-Christophe
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2022
Subjects: subject: Intervals
subject: Contractors
subject: Not a Number
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: [no abstract available]
Household water insecurity experiences and their perceived determinants in a low-income community of Cartagena, Colombia, during a water service expansion project
Creators: name: Stoler, Justin
name: Miller, Joshua D.
name: Lemaitre, Andrea K.
Publisher: name: Public Library of Science
Year: 2023

description: Traditional water indicators primarily focus on water quantity and quality, but emergent research demonstrates that measurement of lived experiences with water availability, accessibility, and use is important for understanding how household water insecurity impacts health and well-being. Few empirical studies have explored which household water insecurity experiences are most salient, or their potential causes, in Latin American cities. We analyzed data from 266 households in a low-income settlement of Cartagena, Colombia, to identify correlates and perceived determinants of water insecurity. The most prevalent household water insecurity experiences were water supply interruptions (96%), water worry (94%), and anger about the water situation (90%). Unexpected water interruptions and use of non-piped primary drinking water sources were associated with greater household water insecurity scores, water worry subscores, and hygiene subscores. Respondents perceived water issues in their community to be caused by deficiencies in gray infrastructure (49%), which included deficiencies in water distribution, treatment, or storage technologies. Social infrastructure (36%), including issues with political, economic, or administrative systems, was also cited as a barrier to water security. We did not detect significant relationships between water insecurity scores and the attribution of these problems to gray or social infrastructure, but there may be relationships between these factors and duration of residency and using a non-piped water source. These findings underscore the importance of socio-political factors and community engagement for improving urban water insecurity through slum-upgrade projects.
Poincaré and mean value inequalities for hypersurfaces in Riemannian manifolds and applications
Creators: name: Alencar, Hilário
name: Neto, Gregório Silva
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C21, 53C42

description: In the first part of this paper we prove some new Poincaré inequalities, with explicit constants, for domains of any hypersurface of a Riemannian manifold with sectional curvatures bounded from above. This inequalities involve the first and the second symmetric functions of the eigenvalues of the second fundamental form of such hypersurface. We apply these inequalities to derive some isoperimetric inequalities and to estimate the volume of domains enclosed by compact self-shrinkers in terms of its scalar curvature. In the second part of the paper we prove some mean value inequalities and as consequences we derive some monotonicity results involving the integral of the mean curvature.
description: 26 pages. Some typos corretions. Accepted for publication at Asian Journal of Mathematics
title: Équilibrage des pressions dans les murs à écran pare-pluie
Creators: name: Rousseau, M. Z.
name: Poirier, G. F.
name: Brown, W. C.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 1998
Subjects: subject: Rainscreen walls
valueUri: urn:ircsubjects:IRC03821
subject: Murs à écran pare-pluie
valueUri: urn:ircsubjects:IRC03821

description: If the pressure in the air chamber behind the rainscreen is less than the pressure in front of it, rain is actually driven into the air chamber, which is, of course, undesirable. Through pressure equalization, this pressure difference is eliminated. A rainscreen wall has vent holes through which air can flow quickly to achieve pressure equalization. Two types of pressures -- static and dynamic -- have to be considered when calculating the size of the vent holes. Also, the pressure in an air chamber is not constant across the facade of a wall. That needs to be considered in their placement.
description: Si la pression dans la chambre à air derrière l'écran pare-pluie est inférieure à la pression qui sévit à l'extérieur du mur, la pluie est en réalité drainée dans la chambre à air, ce qui n'est, bien sûr, pas souhaitable. Un équilibrage des pressions permet d'éliminer ces différences. Un mur à écran pare-pluie est muni d'orifices d'aération au travers desquels l'air peut circuler rapidement pour permettre d'obtenir un équilibre des pressions. Il faut prendre en considération deux types de pressions - statique et dynamique - au moment du calcul de la taille des orifices d'aération. De plus, la pression dans une chambre à air n'est pas constante de part et d'autre de la façade. C'est aussi un élément qui doit être pris en compte pour l'emplacement de ces orifices.
Inhibition of catalase-dependent ethanol metabolism in alcohol dehydrogenase-deficient deermice by fructose
Creators: name: Handler, J A
name: Thurman, R G
name: Glassman, E B
name: Forman, D T
name: Bradford, B U
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: Hepatic microsomal fractions from ADH (alcohol dehydrogenase)-negative deermice incubated with an NADPH-generating system metabolized butanol and ethanol at rates around 10 nmol/min per mg. In contrast, cytosolic catalase from ADH-negative deermouse liver oxidized ethanol, but not butanol, when incubated with an H2O2-generating system. Thus butanol is oxidized by cytochrome P-450 in microsomal fractions, but not by cytosolic catalase, in tissues from ADH-negative deermice. In perfused livers from ADH-negative deermice, rates of ethanol uptake at low concentrations of ethanol (1.5 mM) were about 60 mumol/h per g, yet butanol (1.5 mM) uptake was undetectable (less than 4 mumol/h per g). At higher concentrations of alcohol (25-30 mM), rates of ethanol uptake were about 80 mumol/h per g, whereas rates of butanol uptake were only about 9 mumol/h per g. Because rates of butanol metabolism via cytochrome P-450 in deermice were more than an order of magnitude lower than rates of ethanol uptake in livers from ADH-negative deermice, it is concluded that ethanol uptake by perfused livers from ADH-negative deermice is catalysed predominantly via catalase-H2O2. In support of this conclusion, rates of H2O2 generation, which are rate-limiting for the peroxidation of ethanol by catalase, were about 65 mumol/h per g in livers from ADH-negative deermice, values similar to rates of ethanol uptake of about 60 mumol/h per g measured under identical conditions. Rates of ethanol uptake by perfused livers from ADH-positive, but not from ADH-negative, deermice were increased by about 50% by infusion of fructose. Thus it is concluded that the stimulation of hepatic ethanol uptake by fructose is dependent on the presence of ADH. Unexpectedly, fructose decreased rates of ethanol metabolism and H2O2 generation by about 60% in perfused livers from ADH-negative deermice, probably by decreasing activation of fatty acids and thus diminishing rates of peroxisomal beta-oxidation.
How race, sex and age interact in association with COVID-19 outcomes over time: An analysis of Michigan data
Creators: name: Browne A.
name: Tiako M.J.N.
Publisher: name: Public Library of Science
Year: 2023

description: Background COVID-19 has had a disproportionate impact on racial and ethnic minorities compared to White people. Studies have not sufficiently examined how sex and age interact with race/ ethnicity, and potentially shape COVID-19 outcomes. We sought to examine disparities in COVID-19 outcomes by race, sex and age over time, leveraging data from Michigan, the only state whose Department of Health and Human Services (DHSS) publishes cross-sectional race, sex and age data on COVID-19. Methods This is an observational study using publicly available COVID-19 data (weekly cases, deaths, and vaccinations) from August 31 2020 to June 9 2021. Outcomes for descriptive analysis were age-standardized COVID-19 incidence and mortality rates, case-fatality rates by race, sex, and age, and within-gender and within-race incidence rate ratios and mortality rate ratios. We used descriptive statistics and linear regressions with age, race, and sex as independent variables. Results The within-sex Black-White racial gap in COVID-19 incidence and mortality decreased at a similar rate among men and women but the remained wider among men. As of June 2021, compared to White people, incidence was lower among Asian American and Pacific Islander people by 2644 cases per 100,000 people and higher among Black people by 1464 cases per 100,000 people. Mortality was higher among those aged 60 or greater by 743.6 deaths per 100,000 people vs those 0-39. The interaction between race and age was significant between Black race and age 60 or greater, with an additional 708.5 deaths per 100,000 people vs White people aged 60 or greater. Black people had a higher case fatality rate than White people. Conclusion COVID-19 incidence, mortality and vaccination patterns varied over time by race, age and sex. Black-White disparities decreased over time, with a larger effect on Black men, and Older Black people were particularly more vulnerable to COVID-19 in terms of mortality. Considering different individual characteristics such as age may further help elucidate the mechanisms behind racial and gender health disparities.
Online Identification of the Open-Circuit Voltage of Lithium-Ion Batteries with the Use of Interval Methods
Creators: name: Lahme, Marit
name: Rauh, Andreas
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2022
Subjects: subject: Online identification
subject: Interval methods
subject: Lithium-ion batteries
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: [no abstract available]
Potential intercellular futile cycling of carbohydrates in diabetes
Creators: name: Kleckner, N W
name: Kizaki, Z
name: Thurman, R G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: Diabetes was induced by treating rats with alloxan, and was confirmed by blood glucose values greater than 250 mg/dl. In perfused livers from both normal and diabetic rats, basal rates of O2 uptake were similar (120-130 mumol/h per g). In livers from diabetic rats, basal rates of glucose output of 60 mumol/h per g declined to around 20 mumol/h per g during 1 h of perfusion. Basal glucose production was abolished by pretreatment with an inhibitor of glycogen synthesis, galactosamine (1.5 g/kg), injected 3 h before perfusion. The subsequent infusion of lactate (2 mM) increased O2 uptake and glucose production about 40-50 mumol/h per g in both groups; however, the average maximal increase in glucose output was nearly twice as high in livers from normal (33 mumol/h per g) as from diabetic (18 mumol/h per g) rats. Rates of lactate uptake were also about 50% lower in livers from diabetic than from normal rats, yet rates of ketone-body formation were similar. Miniature O2 electrodes placed on periportal and pericentral regions of the liver lobule were employed to measure local rates of O2 uptake before, during and after infusion of lactate by stopping the flow of perfusate through the liver and measuring the decrease in local [O2]. Local rates of glucose production were calculated from the extra O2 consumed and the known stoichiometry between O2 uptake and glucose production from lactate. In livers from normal rats, glucose was synthesized predominantly in periportal regions of the liver lobule; however, glucose was produced exclusively in periportal regions in livers from diabetic rats. In pericentral regions, O2 uptake increased slightly in livers from normal rats, but declined significantly by 10 mumol/h per g in livers from diabetic rats. These data are consistent with the hypothesis that gluconeogenesis from lactate occurs exclusively in periportal regions of the liver lobule in livers from diabetic rats. A portion of this glucose is metabolized back to lactate in pericentral areas, leading to increased rates of glycolytic ATP production, thereby decreasing the demands for O2. This production of glucose from lactate in periportal regions, followed by conversion of glucose back into lactate in pericentral areas, raises the possibility of intercellular futile cycling, stimulated by diabetes.
title: Pour bien mesurer la corrosion de l’armature du béton à l’aide de relevés de potentiel par demi-pile
Creators: name: Gu, Ping
name: Beaudoin, J. J.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 1998
Subjects: subject: Corrosion (of reinforced concrete)
valueUri: urn:ircsubjects:IRC0743
subject: Corrosion de l'armature du béton
valueUri: urn:ircsubjects:IRC0743

description: An engineer is interested in half-cell potential measurements because they give an idea about the possible state of corrosion of the steel reinforcement in concrete. Interpreting such measurements is trickier than just slapping one electrode here and another one there, and reading something meaningful from a voltmeter. After all, the concrete in the structure may have undergone carbonation, suffered chloride ion intrusion, and been mixed with anodic or cathodic corrosion inhibitors. The measurements are influenced by these and many other factors. Therefore, their correct interpretation is a matter of knowing what exactly the influences amount to.
description: Les ingénieurs s'intéressent aux relevés de potentiel par demi-pile parce que ceux-ci donnent une idée du degré de corrosion de l'armature d'acier contenue dans le béton. Pour interpréter ces relevés, il ne suffit pas de flanquer une électrode ici et une autre là, et de faire la lecture des résultats sur un voltmètre. Après tout, le béton dont est fait l'ouvrage peut avoir subi une carbonatation, sa concentration en ions chlorure peut avoir augmenté, ou on peut lui avoir ajouté un inhibiteur de corrosion anodique ou cathodique. Ces facteurs, et bien d'autres, influent sur les relevés. Pour interpréter correctement ceux-ci, il faut donc connaître l'effet exact de ces facteurs.
Phase diagram of the Kohn-Luttinger superconducting state for bilayer graphene
Creators: name: Kagan, M. Yu.
name: Mitskan, V. A.
name: Korovushkin, M. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The effect of the intersite and interplane Coulomb interactions between the Dirac fermions on the formation of the Kohn-Luttinger superconductivity in bilayer doped graphene is studied disregarding the effects of the van der Waals potential of the substrate and both magnetic and non-magnetic impurities. The phase diagram determining the boundaries of superconductive domains with different types of symmetry of the order parameter is built using the extended Hubbard model in the Born weak-coupling approximation with allowance for the intratomic, interatomic, and interlayer Coulomb interactions between electrons. It is shown that the Kohn-Luttinger polarization contributions up to the second order of perturbation theory in the Coulomb interaction inclusively and an account for the long-range intraplane Coulomb interactions significantly affect the competition between the superconducting $f-$, $p+ip-$, and $d+id-$wave pairings. It is demonstrated that the account for the interplane Coulomb interaction enhances the critical temperature of the transition to the superconducting phase.
description: 10 pages, 7 figures
Recovering simulated planet and disk signals using SCALES aperture masking
Creators: name: Lach, Mackenzie
name: Sallum, Steph
name: Banyal, Ravinder
name: Batalha, Natalie
name: Blake, Geoff
name: Brandt, Tim
name: Briesemeister, Zackery
name: Desai, Aditi
name: Eisner, Josh
name: Fong, Wen-fai
name: Greene, Tom
name: Honda, Mitsuhiko
name: Kain, Isabel
name: Kilpatrick, Charlie
name: de Kleer, Katherine
name: Liu, Michael
name: Macintosh, Bruce
name: Martinez, Raquel
name: Mawet, Dimitri
name: Miles, Brittany
name: Morley, Caroline
name: de Pater, Imke
name: Powell, Diana
name: Sheehan, Patrick
name: Skemer, Andrew
name: Spilker, Justin
name: Stelter, Deno
name: Stone, Jordan
name: Surya, Arun
name: Thirupathi, Sivarani
name: Wagner, Kevin
name: Zhou, Yifan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Slicer Combined with Array of Lenslets for Exoplanet Spectroscopy (SCALES) instrument is a lenslet-based integral field spectrograph that will operate at 2 to 5 microns, imaging and characterizing colder (and thus older) planets than current high-contrast instruments. Its spatial resolution for distant science targets and/or close-in disks and companions could be improved via interferometric techniques such as sparse aperture masking. We introduce a nascent Python package, NRM-artist, that we use to design several SCALES masks to be non-redundant and to have uniform coverage in Fourier space. We generate high-fidelity mock SCALES data using the scalessim package for SCALES' low spectral resolution modes across its 2 to 5 micron bandpass. We include realistic noise from astrophysical and instrument sources, including Keck adaptive optics and Poisson noise. We inject planet and disk signals into the mock datasets and subsequently recover them to test the performance of SCALES sparse aperture masking and to determine the sensitivity of various mask designs to different science signals.
Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes
Creators: name: Momani E.
name: Tropsha A.
name: Baker N.
name: Sabbah D.A.
name: Hajjo R.
Publisher: name: Nature Research
Year: 2023

description: COVID-19 vaccines have been instrumental tools in the fight against SARS-CoV-2 helping to reduce disease severity and mortality. At the same time, just like any other therapeutic, COVID-19 vaccines were associated with adverse events. Women have reported menstrual cycle irregularity after receiving COVID-19 vaccines, and this led to renewed fears concerning COVID-19 vaccines and their effects on fertility. Herein we devised an informatics workflow to explore the causal drivers of menstrual cycle irregularity in response to vaccination with mRNA COVID-19 vaccine BNT162b2. Our methods relied on gene expression analysis in response to vaccination, followed by network biology analysis to derive testable hypotheses regarding the causal links between BNT162b2 and menstrual cycle irregularity. Five high-confidence transcription factors were identified as causal drivers of BNT162b2-induced menstrual irregularity, namely: IRF1, STAT1, RelA (p65 NF-kB subunit), STAT2 and IRF3. Furthermore, some biomarkers of menstrual irregularity, including TNF, IL6R, IL6ST, LIF, BIRC3, FGF2, ARHGDIB, RPS3, RHOU, MIF, were identified as topological genes and predicted as causal drivers of menstrual irregularity. Our network-based mechanism reconstruction results indicated that BNT162b2 exerted biological effects similar to those resulting from prolactin signaling. However, these effects were short-lived and didn’t raise concerns about long-term infertility issues. This approach can be applied to interrogate the functional links between drugs/vaccines and other side effects.
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H 1 -histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists
Creators: name: Nakahata, N
name: Harden, T K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: Although activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells results in a linear accumulation of inositol phosphates for up to 60 min in the presence of LiCl [Masters, Quinn & Brown (1985) Mol. Pharmacol. 27, 325-332], activation of H1-histamine receptors resulted in an increase in total inositol phosphate formation that was maintained for less than 5 min. The effects of stimulation of these two receptors on accumulation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] were also examined. Incubation of 1321N1 cells with carbachol resulted in a rapid accumulation of all three inositol phosphates, reaching a maximum within 30 s; this elevated value was maintained for up to 60 min. The rate of disappearance of Ins(1,3,4)P3 from carbachol-treated cells after the addition of atropine paralleled or exceeded the rate of disappearance of Ins(1,4,5)P3. Although the initial rates of accumulation of Ins(1,4,5)P3, Ins(1,3,4)P3 and Ins(1,3,4,5)P4 in the presence of histamine were similar to that observed with carbachol, the amounts of these inositol phosphates had returned to control values within 5 min after the addition of histamine. The results indicate that, although the acute effects of muscarinic receptor and H1-histamine receptor stimulation on phosphoinositide hydrolysis are very similar, the histamine receptor is desensitized rapidly, whereas the muscarinic receptor is not. This effect on histamine-receptor function is apparently homologous, since preincubation of 1321N1 cells with histamine did not decrease the subsequent response to carbachol.
Identifying sources of antibiotic resistance genes in the environment using the microbial Find, Inform, and Test framework
Creators: name: Stewart J.R.
name: Beattie R.E.
name: Serre M.L.
name: Wiesner-Friedman C.
name: Hristova K.R.
Publisher: name: Frontiers Media SA
Year: 2023

description: Introduction: Antimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined. Methods: To identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region. Results: A one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application of biosolids, sludge, and industrial wastewater (i.e., food processing) and domestic (i.e., municipal and septage)] was associated with 34–80% and 33–77% increases in the relative abundances of the ARGs in riverbed sediment and surface water, respectively. Sources influenced environmental AMR at overland distances of up to 13 km. Discussion: Our study corroborates previous evidence of offsite migration of microbial pollution from bovine sources and newly suggests offsite migration from land-applied waste. With FIT, we estimated the distance-based influence range overland and downstream around sources to model the impact these sources may have on AMR at unsampled sites. This modeling supports targeted monitoring of AMR from sources for future exposure and risk mitigation efforts.
title: Partnership between IGSN and DataCite
Creators: name: Buys, Matt
name: Lehnert, Kerstin
Publisher: name: DataCite
Year: 2021

description: Earlier this year, DataCite and IGSN announced their roadmap towards a partnership to support the global adoption, implementation, and use of physical sample identifiers. Today, we are pleased to share the announcement of the partnership agreement.
Testing interval arithmetic libraries
Creators: name: Revol, Nathalie
name: Benet Fernández, Luis
name: Ferranti, Luca
name: Zhilin, Sergei
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2022
Subjects: subject: Interval Arithmetic
subject: Library
subject: Test
subject: Unit Test
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: [no abstract available]
title: Nouvelles techniques d'evaluation des bâtiments en béton précontraint par post-tension
Creators: name: Rahman, A. H.
name: Pernica, G.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 1998

description: Three new evaluation techniques have been assessed for their ability to determine just how corroded tendons inside unbonded, post-tensioned (PT) systems are. Since these tendons are not openly visible, the evaluation techniques are all indirect. Because corrosion can cause strands of the tendons to snap, one technique monitors the occurrence of that particular noise. In another technique, some air from inside the sheath surrounding the tendon is withdrawn and tested for moisture. The premise is that where there is moisture near steel, there must be rust. The third method uses a transceiver to send signals along the tendon. The returned signal patterns are then analyzed. Two methods proved quite unsatisfactory.
description: On a examiné trois nouvelles techniques d'évaluation pour savoir si elles permettent de déterminer le degré de corrosion des câbles de précontrainte par post-tension non adhérents. Comme ces câbles ne sont pratiquement pas visibles, les techniques d'évaluation sont toutes indirectes. La corrosion pouvant faire casser net les torons des câbles, l'une des techniques consiste à détecter le bruit alors produit. Dans un autre cas, on expulse l'air présent dans la gaine contenant le câble et on mesure sa teneur en humidité. On suppose que s'il y a de l'humidité près de l'acier, il doit y avoir de la rouille. La troisième méthode consiste à utiliser un émetteur-récepteur pour envoyer des signaux le long du câble. On analyse ensuite les caractéristiques des signaux renvoyés. De ces trois techniques, deux se sont révélées très insatisfaisantes.
Statistical Recovery of Simultaneously Sparse Time-Varying Signals from Multiple Measurement Vectors
Creators: name: Choi, Jun Won
name: Shim, Byonghyo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we propose a new sparse signal recovery algorithm, referred to as sparse Kalman tree search (sKTS), that provides a robust reconstruction of the sparse vector when the sequence of correlated observation vectors are available. The proposed sKTS algorithm builds on expectation-maximization (EM) algorithm and consists of two main operations: 1) Kalman smoothing to obtain the a posteriori statistics of the source signal vectors and 2) greedy tree search to estimate the support of the signal vectors. Through numerical experiments, we demonstrate that the proposed sKTS algorithm is effective in recovering the sparse signals and performs close to the Oracle (genie-based) Kalman estimator.
title: Éclairage de bureau modulable : perceptions, choix et économies d’énergie
Creators: name: Newsham, G. R.
name: Veitch, J. A.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 1998
Subjects: subject: Office lighting
valueUri: urn:ircsubjects:IRC0615
subject: Éclairage de bureau
valueUri: urn:ircsubjects:IRC0615
subject: Energy efficiency
valueUri: urn:ircsubjects:IRC0613
subject: Éclairage éconergétique
valueUri: urn:ircsubjects:IRC0613

description: Designers, researchers and the building services community tend to believe that occupants should have individual control over their workplace environments. If most employees would tend to raise light levels only at their own work stations, managers could provide a much lower level of ambient lighting. In fact, among designers, researchers and the building services community are some who suggest that a personally tailored environment promotes job satisfaction, leading to greater performance and hence economic payoffs for the employer. But is all this really so?
description: Les concepteurs, les chercheurs et les spécialistes des équipements du bâtiment croient généralement qu'il vaut mieux donner aux occupants la maîtrise individuelle de leur propre milieu de travail. Il est vrai que la plupart des employés ont tendance à augmenter l'intensité de la lumière à leur poste de travail alors que les directeurs semblent favoriser une intensité lumineuse ambiante plus faible. En fait, parmi les concepteurs, les chercheurs et les spécialistes des équipements du bâtiment, certains pensent qu'un plus grand contrôle individuel sur l'environnement de travail augmente la satisfaction et le rendement, et a donc des retombées économiques pour l'employeur. Sont-ils dans le vrai?
Backscattering in helical edge states from a magnetic impurity and Rashba disorder
Creators: name: Kimme, Lukas
name: Rosenow, Bernd
name: Brataas, Arne
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Transport by helical edge states of a quantum spin Hall insulator is experimentally characterized by a weakly temperature-dependent mean free path of a few microns and by reproducible conductance oscillations, challenging proposed theoretical explanations. We consider a model where edge electrons experience spatially random Rashba spin-orbit coupling and couple to a magnetic impurity with spin S >= 1/2. In a finite bias steady state, we find for S > 1/2 an impurity induced resistance with a temperature dependence in agreement with experiments. Since backscattering is elastic, interference between different scatterers possibly explains conductance fluctuations.
description: 8 pages, 3 figures, contains supplemental material, corresponds to published version
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca 2+ in the presence of calmodulin
Creators: name: Harden, T K
name: Downes, C P
name: Morris, A J
name: Michell, R H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: Turkey erythrocytes contain soluble and particulate kinase activities which catalyse the ATP-dependent phosphorylation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. The particle-bound activity accounts for approximately one-quarter of the total cellular Ins(1,4,5)P3 kinase, when assayed at a [Ca2+] of 10 nM. The particle-bound Ins(1,4,5)P3 kinase is not washed from the membrane by 0.6 M-KCl, yet may be solubilized by a variety of detergents. This suggests that it is an intrinsic membrane protein. The product of the membrane-bound Ins(1,4,5)P3 kinase is inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4], identifying the enzyme as an Ins(1,4,5)P3 3-kinase. In the presence of calmodulin, the membrane-associated Ins(1,4,5)P3 3-kinase is activated as [Ca2+] is increased over the range 0.2-1.0 microM. Under these conditions, the rates of dephosphorylation of Ins(1,3,4,5)P4 and Ins(1,4,5)P3 by phosphatases in the membrane fraction are unchanged.
Impact of taxes and warning labels on red meat purchases among US consumers: A randomized controlled trial
Creators: name: Prestemon C.E.
name: Hall M.G.
name: Taillie L.S.
name: Jaacks L.M.
name: Bercholz M.
name: Higgins I.C.A.
name: Grummon A.H.
Publisher: name: Public Library of Science
Year: 2023

description: Background AU Policies: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly to reduce red meat intake are important for mitigating : climate change and improving public health. We tested the impact of taxes and warning labels on red meat purchases in the United States. The main study question was, will taxes and warning labels reduce red meat purchases? Methods and findings We recruited 3,518 US adults to participate in a shopping task in a naturalistic online grocery store from October 18, 2021 to October 28, 2021. Participants were randomized to one of 4 conditions: control (no tax or warning labels, n = 887), warning labels (health and environmental warning labels appeared next to products containing red meat, n = 891), tax (products containing red meat were subject to a 30% price increase, n = 874), or combined warning labels + tax (n = 866). We used fractional probit and Poisson regression models to assess the co-primary outcomes, percent, and count of red meat purchases, and linear regression to assess the secondary outcomes of nutrients purchased. Most participants identified as women, consumed red meat 2 or more times per week, and reported doing all of their household's grocery shopping. The warning, tax, and combined conditions led to lower percent of red meat-containing items purchased, with 39% (95% confidence interval (CI) [38%, 40%]) of control participants' purchases containing red meat, compared to 36% (95% CI [35%, 37%], p = 0.001) of warning participants, 34% (95% CI [33%, 35%], p < 0.001) of tax participants, and 31% (95% CI [30%, 32%], p < 0.001) of combined participants. A similar pattern was observed for count of red meat items. Compared to the control, the combined condition reduced calories purchased (−312.0 kcals, 95% CI [−590.3 kcals, −33.6 kcals], p = 0.027), while the tax (−10.4 g, 95% CI [−18.2 g, −2.5 g], p = 0.01) and combined (−12.8 g, 95% CI [−20.7 g, −4.9 g], p = 0.001) conditions reduced saturated fat purchases; no condition affected sodium purchases. Warning labels decreased the perceived healthfulness and environmental sustainability of red meat, while taxes increased perceived cost. The main limitations were that the study differed in sociodemographic characteristics from the US population, and only about 30% to 40% of the US population shops for groceries online. Conclusions Warning labels and taxes reduced red meat purchases in a naturalistic online grocery store. Trial Registration: http://www.clinicaltrials.gov/NCT04716010.
Unified dark matter with intermediate symmetry breaking scales
Creators: name: Lonsdale, Stephen J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Asymmetric symmetry breaking models dynamically break the G X G gauge symmetries of mirror models to distinct subgroups in the two sectors. The coincidental abundances of visible and dark matter, $Ω_{DM} \simeq 5Ω_{VM}$, motivates asymmetric dark matter theories where similar number densities of baryons in each sector are explained by their connected origins. However the question of why the baryons of two sectors should have similar mass remains. In this work we develop an alternative class of asymmetric symmetry breaking models which unify the dark and visible sectors while generating a small difference in the mass scale of the baryons of each sector. By examining the different paths that the SO(10) GUT group can take in breaking to gauge symmetries containing SU(3) we can adapt the mechanism of asymmetric symmetry breaking to demonstrate models in which originally unified visible and dark sectors have isomorphic color gauge groups at low energy yet pass through different intermediate gauge groups at high energy. Through this, slight differences in the running coupling evolutions and thus the confinement scales of the two sectors are generated.
description: 15 pages, 5 figures. Revised version to match published version in Phys. Rev. D. References added
Uses of Methods with Result Verification in the Context of MIMO Systems
Creators: name: Auer, Ekaterina
name: Ahrens, Andreas
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2022
Subjects: subject: MIMO
subject: interval analysis
subject: optimization
subject: BER
subject: SVD
subject: GMD
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: [no abstract available]
Additional file 2: of A systematic review and meta-analysis in the effectiveness of mobile phone interventions used to improve adherence to antiretroviral therapy in HIV infection
Creators: name: Shah, Reshma
name: Watson, Julie
name: Free, Caroline
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Search strategy for EMBASE (DOCX 15 kb)
Leptogenesis via Axion Oscillations after Inflation
Creators: name: Kusenko, Alexander
name: Schmitz, Kai
name: Yanagida, Tsutomu T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Once a light axionlike scalar field couples to the electroweak gauge bosons, its classical motion during reheating induces an effective chemical potential for the fermion number. In the presence of rapid lepton number (L)-violating processes in the plasma, such a chemical potential provides a favorable opportunity for baryogenesis via leptogenesis. We are able to demonstrate that L violation due to the exchange of heavy Majorana neutrinos is sufficient for a successful realization of this idea. Our mechanism represents a novel and minimal alternative to thermal leptogenesis, which turns out to be insensitive to the masses and CP-violating phases in the heavy neutrino sector. It is consistent with heavy neutrino masses close to the scale of grand unification and, quite complementary to thermal leptogenesis, requires the reheating temperature to be at least of order 10^12 GeV.
description: 6 pages, 2 figures; v2: slightly extended discussion, matches version published in PRL
Modified heated CGMD simulations for discovering stable docked conformations of BiTE antibody against CD3 and CD117/c-kit
Creators: name: Kadir, Fatin Filzah Nur Abdul
name: Nordin, Muhamad Alif Che
name: Shuid, Ahmad Naqib
name: Omar, Mohammad Tasyriq Che
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: In cancer immunotherapy, the design and optimisation of bispecific antibodies hold great promise. Bispecific T-cell engager (BiTE) antibodies targeting CD3 and CD117/c-kit have shown significant potential in experimental settings. Nevertheless, knowledge on their stable docked conformations at molecular level is still limited. This study presents an approach of employing modified heated coarse-grained molecular dynamics (CGMD) simulations to elucidate the stable docked conformations of BiTE antibodies against CD3 and CD117/c-kit. We integrated molecular dynamics simulation with coarse-grained and temperature control to explore the conformational landscape of these complex interactions. The modified heated CGMD simulation aimed to re-assess the docked poses suggested by ClusPro webserver. Furthermore, the all-atomic trajectories unveiled the dynamic residues formed throughout the simulation process. The per-residue-energy-binding emphasised the crucial amino acids involved in binding within the complex especially between the complementarity-determining regions (CDR) of BiTEs and residues located at the N-terminal of CD117/c-kit and the C-terminal of CD3. The formation of three types of interactions, such as hydrogen bonds, salt-bridge contact and hydrophobic interactions plays a crucial role in the motion, configuration and the free energy landscape of the complexes. This method is a valuable tool for rational drug design especially in the field of cancer immunotherapy.
Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses
Creators: name: Owens, Florida
name: Zhao, Yuling
name: Rodriguez, Myosotys
name: Soler, Yemmy
name: Almohtadi, Rianna
name: El-Hage, Nazira
name: Perry, Marissa
name: Batrakova, Elena V.
name: Stone, Nicole
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: The protein Beclin1 (BECN1, a mammalian homologue of ATG6 in yeast) plays an important role in the initiation and the normal process of autophagy in cells. Moreover, we and others have shown that Beclin1 plays an important role in viral replication and the innate immune signaling pathways. We previously used the cationic polymer polyethyleneimine (PEI) conjugated to mannose (Man) as a non-viral tool for the delivery of a small interfering (si) Beclin1-PEI-Man nanoplex, which specifically targets mannose receptor-expressing glia (microglia and astrocytes) in the brain when administered intranasally to conventional mice. To expand our previous reports, first we used C57BL/6J mice infected with EcoHIV and exposed them to combined antiretroviral therapy (cART). We show that EcoHIV enters the mouse brain, while intranasal delivery of the nanocomplex significantly reduces the secretion of HIV-induced inflammatory molecules and downregulates the expression of the transcription factor nuclear factor (NF)-kB. Since a spectrum of neurocognitive and motor problems can develop in people living with HIV (PLWH) despite suppressive antiretroviral therapy, we subsequently measured the role of Beclin1 in locomotor activities using EcoHIV-infected BECN1 knockout mice exposed to cART. Viral replication and cytokine secretion were reduced in the postmortem brains recovered from EcoHIV-infected Becn1+/− mice when compared to EcoHIV-infected Becn1+/+ mice, although the impairment in locomotor activities based on muscle strength were comparable. This further highlights the importance of Beclin1 in the regulation of HIV replication and in viral-induced cytokine secretion but not in HIV-induced locomotor impairments. Moreover, the cause of HIV-induced locomotor impairments remains speculative, as we show that this may not be entirely due to viral load and/or HIV-induced inflammatory cytokines.
Vitamin K-dependent protein S is similar to rat androgen-binding protein
Creators: name: Joseph, D R
name: Baker, M E
name: French, F S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: Vitamin K-dependent protein S belongs to the family of clotting factors (e.g. Factors IX and X, and protein C). Unlike the other clotting factors, the C-terminal half (residues 250-634) of protein S is not a serine proteinase. In fact, the function of residues 250-634 of protein S is unknown. By using computer programs designed to detect evolutionary relationships between proteins, we find that this part of protein S is similar to rat androgen-binding protein, a protein produced and secreted by testicular Sertoli cells. The homology between protein S and androgen-binding protein suggests new approaches for elucidating their functions.
In-Clinic versus Hybrid Cancer Rehabilitation Service Delivery during the COVID-19 Pandemic: An Outcome Comparison Study
Creators: name: Giri, Smith
name: Pergolotti, Mackenzi
name: Wood, Kelley C.
name: Kendig, Tiffany D.
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: Diminished health-related quality of life (HRQOL) is common among cancer survivors but often amendable to rehabilitation. However, few access real-world rehabilitation services. Hybrid delivery modes (using a combination of in-clinic and synchronous telehealth visits) became popular during the COVID-19 pandemic and offer a promising solution to improve access beyond the pandemic. However, it is unclear if hybrid delivery has the same impact on patient-reported outcomes and experiences as standard, in-clinic-only delivery. To fill this gap, we performed a retrospective, observational, comparative outcomes study of real-world electronic medical record (EMR) data collected by a national outpatient rehabilitation provider in 2020–2021. Of the cases meeting the inclusion criteria (N = 2611), 60 were seen to via hybrid delivery. The outcomes evaluated pre and post-rehabilitation included PROMIS® global physical health (GPH), global mental health (GMH), physical function (PF), and the ability to participate in social roles and activities (SRA). The patient experience outcomes included the Net Promoter Survey (NPS®) and the Select Medical Patient-Reported Experience Measure (SM-PREM). A linear and logistic regression was used to examine the between-group differences in the PROMIS and SM-PREM scores while controlling for covariates. The hybrid and in-clinic-only cases improved similarly in all PROMIS outcomes (all p < 0.05). The association between the delivery mode and the likelihood of achieving the minimal important change in the PROMIS outcomes was non-significant (all p > 0.05). No between-group differences were observed in the NPS or SM-PREM scores (all p > 0.05). Although more research is needed, this real-world evidence suggests that hybrid rehabilitation care may be equally beneficial for and acceptable to cancer survivors and supports calls to expand access to and reimbursement for telerehabilitation.
بررسی افکار کلامی مولوی کرد
Publisher: name: دانشگاه کردستان
Year: 2022

description: دانشمندان ایرانی در همۀ علوم اسلامی و به ویژه در علم کلام اسلامی سهم و جایگاه خاصّی دارند، تا جایی که می توان ادعا کرد که عمده دستاوردهای علم کلام مربوط به ایرانیان است. عالمانی چون امام الحرمین، امام محمّد غزالی، امام فخر رازی، قاضی عضد ایجی، علّامه تفتازانی، علامه دوانی و محقق سیّد شریف جرجانی در این حوزە دارای آثار ممتازی هستند. شاهد دیگر بر این مدّعا آثار گسترده و متنوع و متعددی است که در این حوزه وجود دارد و یکی از این متکلمان مرحوم سیّد عبدالرحیم مشهور به مولوی کُرد است که البته ایشان به جهت تسلطی که بر علم کلام داشته است، آن را در قالب شعر سروده و منظومۀ الفضیله و العقیده المرضیه ایشان در عین اختصار، تمام مباحث کلامی متداول را در خود جای داده است که عالم نامی و مدرس متبحر ملا عبدالکریم مدرس آن را به زبان عربی ساده به عنوان الوسیله شرح کرده است. در این مقاله مقادیری از آرای کلامی ایشان مورد بررسی قرار گرفته است.\n
Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration
Creators: name: King, Jasmine L.
name: Shrivastava, Roopali
name: Benhabbour, Soumya Rahima
name: Shah, Pooja D.
name: Maturavongsadit, Panita
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: Bone fractures are common in the geriatric population and pose a great economic burden worldwide. While traditional methods for repairing bone defects have primarily been autografts, there are several drawbacks limiting its use. Bone graft substitutes have been used as alternative strategies to improve bone healing. However, there remain several impediments to achieving the desired healing outcomes. Injectable hydrogels have become attractive scaffold materials for bone regeneration, given their high performance in filling irregularly sized bone defects and their ability to encapsulate cells and bioactive molecules and mimic the native ECM of bone. We investigated the use of an injectable chitosan-based hydrogel scaffold to promote the differentiation of preosteoblasts in vitro. The hydrogels were characterized by evaluating cell homogeneity, cell viability, rheological and mechanical properties, and differentiation ability of preosteoblasts in hydrogel scaffolds. Cell-laden hydrogel scaffolds exhibited shear thinning behavior and the ability to maintain shape fidelity after injection. The CNC-CS hydrogels exhibited higher mechanical strength and significantly upregulated the osteogenic activity and differentiation of preosteoblasts, as shown by ALP activity assays and histological analysis of hydrogel scaffolds. These results suggest that this injectable hydrogel is suitable for cell survival, can promote osteogenic differentiation of preosteoblasts, and structurally support new bone growth.