cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Countable Borel quasi-orders
Creators: name: Williams, Jay
Publisher: name: No Publisher Supplied
Year: 2012

description: In recent years, much work in descriptive set theory has been focused on the Borel complexity of naturally occurring classification problems, in particular, the study of countable Borel equivalence relations and their structure under the quasi-order of Borel reducibility.  Following the approach of Louveau and Rosendal in cite{LR05} for the study of analytic equivalence relations, we study countable Borel quasi-orders.    We are largely concerned in this thesis with universal countable Borel quasi-orders, i.e. countable Borel quasi-orders above all other countable Borel quasi-orders with regard to Borel reducibility.  We first establish that there is a universal countable Borel quasi-order, using a Feldman-Moore-type result for countable Borel quasi-orders and an argument similar to that of Dougherty, Jackson, and Kechris in cite{DJK94}.  We then establish that several countable Borel quasi-orders are universal.  An important example is an embeddability relation on descriptive set theoretic trees.  This is used in many of the other proofs of universality.    Our main result is Theorem 5.5.2, which states that embeddability of finitely generated groups is a universal countable Borel quasi-order, answering a question of Louveau and Rosendal in cite{LR05}.  This immediately implies that biembeddability of finitely generated groups is a universal countable Borel equivalence relation.  Although it may have been possible to prove this only using results on countable Borel equivalence relations, the use of quasi-orders seems to be the most direct route to this result.  The proof uses small cancellation theory.  The same techniques are also used to show that embeddability of countable groups is a universal analytic quasi-order.    Finally, we discuss the structure of countable Borel quasi-orders under Borel reducibility, and we present some open problems.
Phloridosa (Phloridosa) Sturtevant
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Phloridosa

description: Subgenus Phloridosa Sturtevant
Phloridosa Sturtevant, 1942: 28. Type species, Drosophila floricola Sturtevant, OD (= lutzii Sturtevant).
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 731, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
PHYSICAL EDUCATION AS A TOOL FOR INCLUSIVE EDUCATION: INSIGHTS FROM PEDAGOGICAL PRACTICES
Creators: name: Alessandra, Romano
name: Giuseppe, Martino
Publisher: name: kEITH jOURNAL
Year: 2025
Subjects: Learning; Inclusion; Special Pedagogy

description: Today more than ever, the activation of inclusive projects through the contribution offered by physical education is essential to implement a strong alliance between school and extra-school, between school and family in order to activate a positive contamination of universal and timeless values of motor activities. This becomes essential since the structuring of society requires a cultural and social pact that guarantees in all formal and non-formal environments the learning of skills that could transform children's lives. It is for this reason that physical activity cannot be for the benefit of a few because the aggregative moments that it can express often become a real lifeline for many young people.

In this context, acting through inclusive teaching makes it possible to value and capitalize on the individual differences present in all pupils, with particular attention to situations in which these differences create significant barriers to learning and participation in social life. In fact, for some time now it has ceased to be considered as an access lane only for students with disabilities or special educational needs, qualifying as a quality teaching for all. We can increasingly consider it as a style of teaching, a daily educational and didactic orientation
The relationship of meiotic checkpoint regulation, synapsis, and crossing over in Drosophila melanogaster
Creators: name: White-Brown, Sanese Kania
Publisher: name: No Publisher Supplied
Year: 2012

description: Proper chromosome segregation is achieved through three important meiotic events. The first is synapsis, where a proteinaceous structure, the synaptonemal complex (SC), forms between homologous chromosomes and juxtaposes them together. Then, recombination, which is initiated by programmed double strand breaks (DSBs) introduced into DNA that leads to a crossover event. Chiasmata, which are physical markers of where an exact exchange of genetic material occurred between homologous chromosomes during crossing over, are important to maintain the genetic integrity and variability of offspring. Zip3, a conserved meiotic protein found in budding yeast to humans, has been found to be required for crossing over. Furthermore, previous studies in budding yeast (Zip3) and C. elegans (ZHP-3) have shown the homologs to be crossover markers. However, the exact mechanism as to how Zip3 combines synapsis and recombination to promote crossing over is unknown.   In Drosophila melanogaster, there are two homologs of Zip3, Zip3 related protein on the third and X chromosome (Z3rp3 and Z3rpX). Because Drosophila currently does not have a way to visualize crossovers, this study involves determining the function of Z3rp3 and Z3rpX during meiotic recombination and if they are crossover markers. HA-tagged transgenes were constructed to express the protein of each homolog. Z3rp3 HA and Z3rpX HA transgenes revealed an abnormal localization pattern, resulting in them not being good crossover markers. However, the transgenes displayed dominant negative effects on meiosis, indicating they had another important function on the process. Loss of function mutants created in z3rp3 and z3rpX showed that they not only had separate functions on the events of meiosis leading to proper chromosome segregation, but also that they seemed to be redundant, since the z3rpX z3rp3 double mutant exhibited the most severe phenotypes on synapsis, recombination, and crossing over. Overall, z3rp may be playing similar roles in the communication between SC formation and recombination events as in budding yeast and C. elegans, but in different contexts. Thus, I have results that provide new insights into the functional features of z3rp in Drosophila that confirms its role in crossing over.
Rhinolophus deckenii Peters 1868
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Rhinolophidae
Rhinolophus
Rhinolophus deckenii

description: Rhinolophus deckenii Peters 1868
A single male specimen assigned to this species was collected from Chinizuia forest. It had a round- ed connecting process, similar to R. clivosus, but the 1st upper premolar was large and partly within the toothrow. Although the location of the premolar was atypical for R. deckenii (in which it is typically outside the toothrow), this character is variable in R. deckenii and occasionally the premolar is located partly within the toothrow (Csorba et al., 2003). The skull had well developed zygomatic arches, sagittal and occipital crests and moderately inflated anterior medial narial inflations. Cranial measurements (Table 2) fell within the range of values given for R. deckenii in Csorba et al. (2003), although greatest skull length was identical to the minimum value of that recorded for R. deckenii. The baculum is characteristic of R. deckenii (as figured in Cotterill, 2002) in both length (3.8 mm cf. 3.9 mm in Cotterill, 2002) and shape (Fig. 3). Peak echolocation frequency of a single male was recorded at 72 kHz (ANABAT, n = 1).
Field measurements: FA (adult male) 49.9 (1); Bm (adult male) 15.5 (1). Nose-leaf width was 8.9 for the single male.
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Role of HIV-1 Integrase During Reverse Transcription
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A statistic released by the United Nation Program on HIV/AIDS in 2004 estimated that 40 million people worldwide are living with HIV. Considering that a majority of those infected will ultimately develop AIDS, the world community has an urgent need for therapeutic treatments that can effectively stop the disease progression in these HIV-positive individuals. In light of the fact that we currently do not have a cure and the availability of a vaccine is uncertain, the development of inhibitors that are specifically directed against additional new targets is critical in the fight against AIDS. Availability of such novel drugs will further improve the efficacy of existing chemotherapeutic regimens, while reducing their toxic side effects and retarding the emergence of drug-resistant viruses. The viral protein integrase (IN) represents an attractive new target for which specific inhibitors have yet to be identified. IN mediates the integration of HIV DNA into the host cell chromosome. The viral DNA is initially generated by another viral protein called reverse transcriptase (RT). RT converts the RNA genome of HIV to a DNA copy shortly after infection in a process called reverse transcription. Both the steps of reverse transcription and integration are essential to the HIV life cycle. We recently discovered that IN, in addition to playing a key role during integration, physically interacts with RT and may have a critical function during reverse transcription. The goal of this application is to gain a better understanding of IN functions during reverse transcription. The specific aims are (1) to determine if the interaction between RT and IN occurs within the viral particle or inside the infected cell, and whether the interaction is important for viral replication to proceed, and (2) to understand the mechanism by which IN affects the RT-catalyzed reverse transcription. We will employ state-of-the-art biochemical and molecular biology techniques to test our hypothesis and to achieve our stated objectives. The experiments will shed light on the interaction between two key HIV proteins and the effect of such an interaction on the essential step of reverse transcription. The new information will lead to a better understanding of HIV replication, and will form the basis for devising new anti-HIV strategies that target RT-IN interactions.
Neotrygon westpapuensis Borsa, Arlyza, Hoareau & Shen 2017
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Neotrygon
Neotrygon westpapuensis

description: Neotrygon cf. westpapuensis
West Papuan Maskray
Local synonymy: White et al., 2018: 246, figs (PNG). Some of the records listed for N. cf. trigoinoides above may refer to this species.
PNG voucher material: CSIRO unregistered, adult male 37 cm DW, CSIRO unregistered, female 22 cm DW, Wewak, East Sepik Province, September 2017.
Remarks: Colour and genetic differences distinguish this species from N. australiae and N. cf. trigonoides. Base don coloration and CO1 sequence data, this species is most similar to and possibly conspecific with the recently described N. westpapuensis Borsa, Arlyza, Hoareau & Shen, 2017 from Cenderwasih Bay. Unfortunately this description was based almost entirely on DNA with no useful field characters provided which prevented detailed comparisons without examing specimens.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 59, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Regulation of telecommunications in the broadband age
Creators: name: Waring, David L.
Publisher: name: No Publisher Supplied
Year: 2012

description: Broadband is becoming important to both the economic and social progress of a  nation. Commerce and social interaction are increasingly conducted “on line.” The  economic importance of broadband has been theoretically framed in terms of the  “network effect.” Additionally, broadband may produce significant positive externalities  in areas such as education, healthcare, and the environment. For these reasons,  policymakers have been closely monitoring the progress of broadband diffusion.    I examine a decade of hard data on the rollout of first generation broadband in the  context of policies employed by different administrations around the world. My primary  focus is in the use of industrial policy and loop unbundling. As in previous studies in the  literature, the dependent variable modeled is broadband subscribers per 100 inhabitants.  The impact of industrial policy is consistently a statistically significant predictor of  broadband density, with a stable value and positive sign over all regressions. The use of  an unbundling policy is found to be statistically significant when lagged by one or two  years, and it is always positive.    I use these results to predict policy impacts on the rollout of Next Generation  Network (NGN) broadband, which will be characterized by heavy investment in fiber  optic facilities supporting access speeds of 100 megabits per second and above. I conduct  a benefit-cost analysis for U.S. NGN broadband deployment using predicted increases in  NGN availability to drive the compilation of associated costs and benefits. To monetize  benefits, I estimate private producer and consumer surpluses. I also include benefits to  the economy by virtue of the network effect. Additional positive externalities can be  optionally added in the areas of healthcare and the environment.    A number of different scenarios are run in order to get a sense of the impact of the  two policies and the sensitivity to different study parameters. The results show that both  policies have the potential to be justified on the basis of a benefit-cost analysis. The more  that we can attribute positive externalities to a modern, high speed broadband network,  the stronger the case there is to justify policies which promote and invest in broadband.
Partnerships and HIV Risk among Drug Users in Los Angeles
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Drug use has been shown to have a significant place in the epidemiology of the HIV epidemic in Los Angeles County (LAC). Intervention efforts have targeted risk associated with drug use; however, it is now understood that sexual behavior among drug users may have a larger impact on their risk of infection than previously thought. Given the complexities of the HIV epidemic among drug users, strategies targeting this population must be comprehensive, addressing not only characteristics of drug use behavior, but also those associated with sexual behavior, including partnership dynamics. More research is needed to better understand the interaction between these factors and develop a more comprehensive intervention approach to the HIV epidemic in the drug user population. The purpose of this study is to identify partnership types among drug users and the effect of these types on risk behaviors (both sexual and drug use) and HIV/Hepatitis C Virus (HCV) prevalence and transmission. In addition, partnership characteristics among drug users and their relationship with risk behaviors and HIV/HCV prevalence will be explored in the context of bridging between different sexual networks. Participants were asked to describe their relationships with their primary sexual partners, as well as other casual or sex-trading partners. This information will also be used to identify the determinants of having different types of partners by demographics and personal risk history Data analysis will first be conducted using the data collected through the Drug User Intervention Trial (DUIT) study survey in LAC. This analysis will examine associations between sexual and drug use behaviors, demographics, and HIV/HCV prevalence with partnership types. For the other portion of the study, in-depth interviews will be conducted that focus on the intersection between sexual identity, sexual behaviors, drug use, HIV/HCV-risk behaviors, and social and cultural networks. Information collected using these methods will provide an understanding of how potential “bridgers” regard their sexual, familial, and cultural identification and how these factors influence decisions to engage in drug use and HIV sexual risk behaviors. The examination of partnership types in this context will provide a better conception of the relationship between partnership dynamics, drug use, sexual behavior, and risk of HIV infection. Based on these findings, interventions may be developed that are sensitive to the influence of partnership dynamics and high-risk behavior within the drug user population. Such interventions may facilitate the interruption of transmission networks and empower drug users to make safer decisions regarding their drug use, sexual behavior, and partnerships.
Phloridosa lutzii Sturtevant 1916
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Phloridosa
Phloridosa lutzii

description: lutzii Sturtevant, 1916: 340. Type locality: Cuba, Ciudad de la Habana, Habana (=Havana). HT M (AMNH). NE NT Distr.: Antilles, California, Cuba, Florida, Mexico to Argentina. Colombia (Bogota, D:C). Refs.: Hunter, 1960. floricola Sturtevant, 1942: 42. Type locality: USA, California, Los Angeles County. ST B AMNH?. Syn. Vilela & Bächli, 1990: 132.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 731, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Pastinachus Ruppell 1829
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Pastinachus

description: Genus Pastinachus Rüppell, 1829
Cowtail Rays
Pastinachus Rüppell, 1829: 51. Type species Raja sephen Forsskål 1775, by subsequent designation (Garman 1913: 375).
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 59, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Siphlodora (Siphlodora) Patterson & Mainland
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Siphlodora

description: Subgenus Siphlodora Patterson & Mainland
Siphlodora Patterson & Mainland, 1944: 25. Type species, Drosophila sigmoides Loew, OD.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 732, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Pastinachus ater
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Pastinachus
Pastinachus ater

description: Pastinachus ater (Macleay, 1883a)
Broad Cowtail Ray
Taeniura atra Macleay, 1883a: 598. Holotype: AMS I.9762. Type locality: Port Moresby district, Papua New Guinea.
Local synonymy: Trygon sephen— Peters, 1877: 853 (New Britain); Ogilby, 1888: 20 (southeastern New Guinea); Günther, 1910: 495 (New Britain); Duncker & Mohr, 1934: 84 (Seeadler Harbour, Manus). Taeniura atra Macleay, 1883a: 598 (Port Moresby district). Dasyatis sephen— Fowler, 1934: 386 (Port Moresby); Munro, 1958: 114 (New Guinea); Munro, 1967: 15, pl. 2, fig. 19 (New Guinea); Haines, 1979a: 6 (Purari Delta); Haines, 1979b: 94 (Purari Delta). Pastinachus dephen - Filewood, 1973: 12 (PNG, misspelling of sephen). Pastinachus atrus— Last & Stevens, 2009: 456 (New Guinea). Pastinachus sephen — Allen, 1998: 67 (Milne Bay); Allen et al., 2003: 112 (Milne Bay). Pastinachus ater— White et al., 2018: 34, figs (PNG).
PNG voucher material: (4 spec.) AMS I.9762 (holotype), female 404 mm DW, Port Moresby, 9°29’ S, 147°05’ E, 1883; KFRS E.043 (dried jaws), adult male, Rabaul, East New Britain, 1964; KFRS E.044 (dried jaws), adult male, Kairuku, Yule Island, Central Province, 18 Jan. 1965; USNM 218543, juvenile male 410 mm DW, Parama Island, Western Province, 15 Dec. 1975.
Remarks: First recorded from PNG by Peters (1877) as Trygon sephen from New Britain. Macleay (1883a) described as a new species, Taeniura atra, based on a specimen collected from off Port Moresby; subsequently included in the synonymy of Pastinachus sephen but recently resurrected as a valid species. Caught occasionally by prawn trawlers and probably also by coastal fishers.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 59, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Rhinolophus fumigatus Ruppell 1842
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Rhinolophidae
Rhinolophus
Rhinolophus fumigatus

description: Rhinolophus fumigatus Rüppell 1842
Continued
Identified on the basis of wide noseleaf (> 9 mm) and hairy sella, three specimens were collected at two sites in northern Mozambique. Peak echolocation call of a single male was 54 kHz (ANABAT), which is almost identical to the peak frequencies recorded in South Africa (53.7 kHz — Schoeman and Jacobs, 2008; Monadjem et al., 2010).
.
2
ABLE
T
Field measurements: FA (adult male) 51.6 ± 1.97 (50.1–53.8, 3); Bm (adult male) 12.0 ± 1.00 (11.0– 13.0, 3). Mean nose-leaf width was 11.03 ± 0.60 for the three males.
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on page 378, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Solvent-free extraction of anthocyanins by soy globular proteins
Creators: name: Wang, Yuxin
Publisher: name: No Publisher Supplied
Year: 2012

description: According to the global health risks report（2009）, insufficient intake of fruit and vegetables was estimated to cause around 14% of gastrointestinal cancer deaths, about 11% of ischemic heart disease deaths and about 9% of stroke deaths worldwide (Mathers, Stevens et al. 2009). Anthocyanins, a major type of phytonutrient in berry, are considered to be able to provide the positive effect on health and it has been drawn great attention by institution and food industry. Thereby, it is significant to concentrate the anthocyanins into food matrix by an efficient method. This study covers the adsorption process of the cranberry juice anthocyanins by soy protein isolate (SPI). Provided results indicate that the soy protein isolate can effectively adsorb the anthocyanins and can be used for successful extraction of it from the low acid juice matrix. The adsorption capabilities of the SPI are tested at various temperature and pH values. It is found that the optimal processing condition for the adsorption is with 45℃ at pH 7. Particle size and zeta potential of the SPI are investigated, and the results of conformational changes in soy protein as the processing conditions vary describe the mechanism of adsorption. Chemical changes in vibrational spectra of soy protein and anthocyanins are monitored. Mathematical modeling of the adsorption equilibrium reveals that both Langmuir and Dubinin–Radushkevich isotherms well describe the adsorption equilibrium of anthocyanins onto soy protein isolate, and process kinetics follows the pseudo-first order. The mean free energy of adsorption per molecule of adsorbate (i.e. anthocyanins) is equal to 1.96 kJ/mol, which corresponds to an electrostatic physicosorption nature of anthocyanins–soy protein interaction. Proposed processing method for the extraction of health-promoting phytonutrients from cranberry juice by plant protein matrix can be applied for wide range of juices and extracts and used for development of new high value food products.
A regulatory element for interneuron progenitors in the developing vertebrate central nervous system
Creators: name: Tzatzalos, Evangeline
Publisher: name: No Publisher Supplied
Year: 2012

description: The development of the central nervous system (CNS) is regulated by non-protein coding gene regulatory elements that control the expression of neural stem cell genes via the interaction of protein trans-acting factors.  As a result of recent progress in neuroscience and biotechnology, valuable insight into neural cell growth has been attained from important components of the neural stem cell protein expression profile.  However, the role of cis-regulatory elements (non-protein coding genomic DNA on the same molecule) in neural stem cells remains confounded.  A cis-regulatory element of neural progenitors during vertebrate development has been identified and characterized.  This regulatory element is a conserved, non-protein coding region located within the established neural stem cell gene, Notch1.  Notch1 is expressed in radial glia, which are self-renewing, neural stem/progenitor cells with long processes that serve as scaffolds for neuronal migration.  A conserved non-coding region in the Notch1 locus (i.e., Notch1CR2) is active exclusively in the ventral CNS during neurogenic periods.  On a cellular level, it is active in asymmetrically dividing cells that give rise to GABAergic interneuron progenitors and interneurons.  Notch1CR2 is a novel regulatory element for interneuron progenitors.  In this thesis, four studies of Notch1CR2 are presented.  In the first study, CNS-specific regulatory activity of Notch1CR2 is revealed during chick embryonic development using in ovo electroporation.  Second, the temporal-spatial profile of Notch1CR2 activity is determined to be present in cells with an interneuron progenitor phenotype using a transgenic mouse model.  Third, the molecular mechanism of Notch1CR2 is investigated, and potential binding trans-acting factors of Notch1CR2 are identified.  Finally, Notch1CR2 reveals a change in the interneuron progenitor population in the reeler mutant mouse compared to the wildtype.  Reeler is a mutant mouse with deficiencies in neuronal migration and lamination.  The discovery and characterization of Notch1CR2 contributes to the current knowledge of gene regulatory elements involved in the neural stem cell decision-making process.  Notch1CR2 has the potential to serve as a tool for studying interneurons in other neurodegenerative models or as a platform for engineering cells for transplantation in patients with interneuron deficiencies.
Interfacial interactions of nanoparticles with surfactants and polymers
Creators: name: Tomasini, Michael D.
Publisher: name: No Publisher Supplied
Year: 2012

description: Nanotechnology is an emerging field with the promise for new materials and applications, particularly in the medical field for diagnosis and treatment of disease. The high surface area to volume ratio of nanoparticles gives rise to useful material properties such as enhanced solubility and dissolution for drug nanoparticles as well as superparamagnetism in the case of magnetic nanoparticles. Often, nanoparticle interactions with surfactants and polymers arise in a variety of scenarios: the production and stabilization to reduce particle agglomeration, to aid in nanoparticle delivery to specific areas of the body, increase bioavailability by avoiding body clearance mechanisms, add desired functionality, and finally the biological targets of nanoparticles are often the surfactants (lipids of the cell membrane) or polymers (proteins) of the body. Understanding the interfacial interactions of nanoparticles with polymers or surfactants is therefore crucial in proceeding ahead with nanoparticles as viable options for medical treatments. In this dissertation, a series of computational techniques are employed to elucidate the interfacial interactions at the molecular level between surfactants, polymers, ii  and nanoparticles in three different case studies. First, Molecular Dynamics and Dissipative Particle Dynamics simulation methods are used to study the stability of a model cell membrane to an applied stress in order to mimic the interactions that occur in magnetic fluid hyperthermia, a nanoparticle-based treatment for cancerous tumors. Here, the aim is to determine if magnetic nanoparticles are capable of generating mechanical forces sufficient to rupture a cell membrane. Secondly, coarse-grained Molecular Dynamics is utilized to explore the interaction of micelle-forming amphiphilic molecules interacting with the human scavenger receptor A for use in preventing uptake of oxidized low-density lipoproteins. Finally, Monte Carlo simulations are developed to study nanocrystal nucleation from solution in the presence of polymers to determine factors that act to promote or inhibit nucleation.  iii
Literary song
Creators: name: Trudell, Scott A.
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation traces the development of verse with a musical dimension fromSidney and Shakespeare to Jonson and Milton, in genres ranging from prose romance and printed songbooks to outdoor pageantry and professional theater. Song was an essential part of the early modern literary canon, and it circulated ubiquitously in written format. Yet it was also highly performative, inseparable from the rhythmic, vocal and instrumental conditions of its recital. As such, song brings out the extensive interaction between writing and sound in sixteenth- and seventeenth-century literary culture. Drawing on media theory, I argue that song reveals a continual struggle to define literature, from Sidney’s emphasis on the musical properties of writing in The Defence of Poesie to Milton’s conception of the printed book as a profoundly performative medium in Areopagitica. I use song to rethink Shakespeare’s Ophelia, whom I see as a disruptive, non-scriptive versifier whose mad songs amount to an extreme type of poetry. And I follow song to less familiar territory, including the pageants that paraded music and verse through the streets of London, mixing the belletristic writings of England’s leading poets with the cacophonous disorder of popular crowds. Focusing on song’s place at thethreshold of script and acoustic performance, I theorize literature as a process ofmediation – an intersection of technologies, performers, formats and authors in which writing was an important but by no means exclusive component.
Siphlodora flexa Loew 1866
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Siphlodora
Siphlodora flexa

description: flexa Loew, 1866: 182. Type locality: Mexico, Distrito Federal, El Desierto de Los Leones. ST B (MCZ). NE NT Distr.: Antilles, Cuba, Mexico to Argentina. Colombia (Antioquia (Medellin), Valle del Cauca (Palmira). Refs.: Wheeler, 1957: 80; Vilela & Bächli, 2000: 29.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 732, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Pateobatis Last, Naylor & Manjaji-Matsumoto 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Pateobatis

description: Genus Pateobatis Last, Naylor & Manjaji-Matsumoto, 2016b
Whiprays
Genus Pateobatis Last, Naylor & Manjaji-Matsumoto, 2016b: 362. Type species Trygon uarnacoides Bleeker, 1852, by original designation.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 59, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Characterizing HIV-induced interferon response in the thymus
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Interferon-alpha plays an important role in controlling infections. It serves as a signal to warn cells that a viral, or bacterial, infection has begun. Infected cells secrete interferon-alpha which leads to the production of a wide variety of proteins that are meant to interfere with the spread of the infection, including the antiviral protein MxA. To date, a detailed understanding of the role of interferon-alpha in HIV infection does not exist. However, we have shown that its production in the human thymus can delay viral replication. The objective of this proposal is to understand how HIV strains that use different receptors (CXCR4 or CCR5 using viruses) can elicit the production of interferon alpha and lead to the synthesis of MxA. The first objective is to understand whether the virus itself or the cell the virus targets are more important for the induction of secretion of interferon-alpha. CXCR4 using or CCR5 using viruses may differ in their ability to produce an interferon response. We believe that CCR5 using viruses may trigger a stronger interferon response which may account for their reduced ability to establish productive infection in the thymus. We would also like to determine where the viral infection takes place. The HIV receptors, CXCR4 and CCR5 are located in very different regions of the organ. Both the strength and location of the interferon-alpha response may influence the ability of HIV to establish a productive infection in the thymus. The second objective is to examine the interaction between the antiviral MxA protein and HIV itself. MxA has been shown to interfere with the assembly of new virus particles. We would like to understand if MxA can slow the rate of HIV infection by blocking the steps necessary for the building infectious virus particles. The ability of a virus to trigger interferon-alpha is an important factor in determining how efficient a virus is. Determining how interferon-alpha is produced in response to HIV will allow us to understand how HIV establishes infection in the human thymus. Furthermore, the study of the interaction of HIV with natural antiviral proteins, such as MxA, will provide additional information for the development of an effective therapeutic HIV vaccine. Vaccines that are capable of stimulating the synthesis of proteins that can inhibit HIV replication will have the best chance of effectively reducing the viral load of previously infected patients.
Nicotiana sylvestris, a model plant for cell biology
Creators: name: Thyssen, Gregory N.
Publisher: name: No Publisher Supplied
Year: 2012

description: Nicotiana sylvestris is a diploid tobacco plant that is amenable to laboratory  manipulation including facile transformation of nuclear and plastid (chloroplast)  genomes. In three separate studies, I used this model organism to observe biological  processes with evolutionary and biotechnological implications.     The first addresses the mechanisms of horizontal gene transfer by  demonstrating cell-to-cell movement of plastids. We grafted Nicotiana sylvestris  plants with selectable transgenic plastid genomes to Nicotiana tabacum plants with  selectable transgenic nuclear markers. Grafting triggers formation of new cell-tocell  contacts, creating an opportunity for organelle movement between the plant  cells. I present evidence for cell-to-cell movement of the entire 161-kb plastid  genome in these plants, most likely in intact plastids. Acquisition of plastids from  neighboring cells provides a mechanism by which cells may be repopulated with  functioning organelles.     My second objective was to determine whether exceptional pollen transmissionof plastids is accompanied by paternal mitochondria transmission in Nicotiana  sylvestris. Plastids and mitochondria in Nicotiana are normally both inherited from  the maternal parent. We observed that plastids from the N. sylvestris father were  transmitted at a low (~0.002%) frequency via pollen. The plants that inherited  paternal plastids did not carry paternal mitochondrial DNA, indicating that leakage  of plastids via pollen can produce plant lines with unrelated plastids and  mitochondria.     My third objective was to observe the behavior of an individual high-copy  retrotransposon in N. sylvestris, its native host. Long terminal repeat (LTR)  retrotransposons are major components of the nuclear genomes of plants, animals  and fungi. The “copy-and-paste” life cycle of retrotransposons accounts for their  accumulation in host genomes and permits the assumption that LTRs are identical  at the time of insertion. Our objective was to experimentally determine if an  introduced synthetic element would interact with native high-copy elements during  retrotransposition. I present evidence that S-TNT1 co-packaged with native TNT1  elements to produce hybrid insertions with swapped LTRs and multiple  recombinations within the gag-pol gene. We can best explain our observations by  dimerization and co-packaging of TNT1 gRNAs in the cytoplasm, followed by  template-switching during minus-strand DNA synthesis, which we term the “mixand-  paste” pseudodiploid mating system for LTR-retroelements.
Rhinolophus hildebrandtii Peters 1878
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Rhinolophidae
Rhinolophus
Rhinolophus hildebrandtii

description: Rhinolophus hildebrandtii Peters 1878
This species was recorded at eight sites in southern, central and northern Mozambique. A large colony was discovered in a cave system in the Cheringoma plateau (Appendix I). Peak echolocation frequencies ranged between 35–40 kHz (ANABAT, Pettersson D240x, n = 15). Variable peak echolocation frequencies for R. hildebrandtii populations have previously been recorded in Southern Africa (Monadjem et al., 2010). For example, calls recorded in South Africa have intermediate peak frequencies of ≈ 33 kHz at Sudwala caves and ≈ 44 kHz at Pafuri, in the Kruger National Park (Schoeman and Jacobs, 2008; M. C. Schoeman, unpublished data). At Lutope Gorge, just south of Sengwa in Zimbabwe, 17 individuals with peak frequencies of ≈ 37 kHz and one with 46 kHz were captured and recorded (Taylor et al., 2005). Based on the analysis of two mtDNA genes (cytochrome b and control region), two divergent lineages of R. hildebrandtii are present in Mozambique (referred to as Clade1 and Clade 2 in Table 2), one comprising smaller-sized individuals occurring in savanna habitats at lower elevations (Namapa, Niassa Game Reserve, Gerhard’s Cave — Clade 2) and another comprising large-sized individuals from montane habitats (Mounts Mabu and Inago — Clade 1) (P. J. Taylor, S. Stoffberg, A. Monadjem, F. P. D. Cotterill, and M. C. Schoeman, unpublished data). These two forms are morphologically distinct as shown by the non-overlap between them in most cranial measurements (Table 2).
Field measurements: For the low elevation taxon, FA (adult male) 63.3 ± 1.40 (60.1–65.2, 12); Bm (adult male) 30.9 ± 2.57 (28.0–34.5, 12); FA (adult female) 62.2 ± 2.16 (59.6–64.6, 4); Bm (adult female) 27.88 ± 5.04 (23.5–34.0, 4). Mean nose-leaf width was 14.36 ± 0.49 for males (n = 12) and 14.35 ± 0.72 for the females (n = 4). For two females from Mounts Mabu and Inago (montane form), mean FA was 67.5 (66–69) mm. Nose-leaf width for these two females was 15.0 and 15.1 mm.
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on page 378, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Sophophora Sturtevant
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Sophophora

description: Subgenus Sophophora Sturtevant
Sophophora Sturtevant, 1939: 139. Type species, Drosophila melanogaster Meigen, OD.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 732, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Sophophora ananassae Doleschall 1858
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Sophophora
Sophophora ananassae

description: ananassae Doleschall, 1858: 128. Type locality: Indonesia, Maluku, Ambon. T A?. NE PA OR NT AF AU Distr.: peridomestic in tropical and subtropical areas. Colombia (Cundinamarca (Fusagasugá), Magdalena (Sierra Nevada de Santa Marta)). Refs.: Hunter & Navarro, 1969: 1102; Hoenigsberg, 1995a: 87.
imparata Walker, 1859: 126. Type locality: Indonesia, Maluiku, Aru Is. T F not in (BMNH). Syn. de Meijere, 1908: 159. Citation of HT in Rocha Pité & Tsacas, 1980: 42.
similis Lamb, 1914: 347. Type locality: Seychelles, Silhoutte, Mare aux Cochons, over 1000 ft, Mahé, Cascade Estate, 800 ft or above. ST M (CUMZ) not in (BMNH). Preocc. Williston 1986. Syn. Duda 1926: 98. Citation of HT in Rocha Pité & Tsacas, 1980: 43.
errans Malloch, 1933: 21. N. n similis Lamb.
caribea Sturtevant, 1916: 335. Type locality: Cuba, Ciudad de la Habana, Habana (=Havana). HT M (MCZ). Syn. Duda, 1926: 98.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 732, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Effect of processing on the antioxidant activity and other quality parameters of Muscadine grape juice
Creators: name: Thakkar, Siddhi
Publisher: name: No Publisher Supplied
Year: 2012

description: Muscadine grapes are native to southeastern parts of the United States. They are widely processed into juices and wines. They contain high amounts of polyphenols that are generally known to have high levels of antioxidant activity, offering potential health benefits. Since the juice is always consumed after processing, the effect of processing on the antioxidant activity and other quality parameters needs to be determined.    Unpasteurized Muscadine grape juice was obtained from Paulk vineyards in Georgia. Juice was thermally pasteurized at 85 °C for 53 s. To obtain microbiologically safe conditions for High Pressure Processing (HPP) of juice, microbial equivalence between thermal processing and HPP was established using Saccharomyces cerevisiae strain. For HPP, the juice was vacuum packed in pouches and processed at pressures ranging from 275 - 425 MPa for 5 - 15 min. Total phenolics in juice samples were measured using Folin - Ciocalteu method. The antioxidant activity was determined using chemical antioxidant assay - Oxygen Radical Absorbance Capacity (ORAC) and biological antioxidant assay - Cellular Antioxidant Activity (CAA) assay. ‘Difference from Control’ sensory test was performed to find the overall difference in the sensory quality of unpasteurized and processed juice samples. The effect storage time and temperature on total phenolics, ORAC value, color and ellagic acid content was determined for the processed juice samples.   Results showed no significant change in total phenolics and ORAC value, after processing. Cellular antioxidant activity increased significantly in high pressure processed sample as compared to thermally processed sample. No overall difference was perceived during sensory evaluation between any of the samples. During storage, total phenolics and ORAC value decreased with time, but the choice of process had no impact on these parameters. Browning index (BI) calculated from measured color indicators, was different for thermally processed and high pressure processed samples, but both samples showed an increase in the BI with time. Ellagic acid content was found to be higher in high pressure processed storage samples compared to unpasteurized and thermally processed samples. Thus, HPP did not offer any special benefit over traditional thermal processing for Muscadine grape juice.
Pateobatis Last, Naylor & Manjaji-Matsumoto 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Pateobatis

description: Pateobatis fai (Jordan & Seale, 1906)
Pink Whipray
Himantura fai Jordan & Seale, 1906: 184, Fig. 2. Holotype: USNM 51712. Type locality: Apia, Upolu Island, Samoa.
Local synonymy: White et al., 2018: 250, figs (PNG).
PNG voucher material: (1 spec.) KFRS E.689, west of Oriomo River, Western Province, 9°4’26.04” S, 143°8’31.9” E, 26 Oct. 2014.
Remarks: Previously placed in the genus Himantura.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on pages 59-60, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878