title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð½ÐµÑÐºÐ°Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»Ð¸Ð¸Ð¼Ð¸Ð´Ð¾Ð² Ð´Ð»Ñ ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð¹ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of nonwoven materials based on aromatic polyimides for tissue engineering
Creators: name: Ð§Ð¸ÑÑÑÑÐµÐ²Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð°ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸Ð¸Ð¼Ð¸Ð´
Ð²Ð¾Ð´Ð¾ÑÐ°ÑÑÐ²Ð¾ÑÐ¸Ð¼ÑÐµ ÑÐ¾Ð»Ð¸ Ð¿Ð¾Ð»Ð¸Ð°Ð¼Ð¸Ð´Ð¾ÐºÐ¸ÑÐ»Ð¾Ñ
Ð´Ð¸Ð°Ð¼Ð¸Ð½Ð¾Ð´Ð¸ÑÐµÐ½Ð¸Ð»Ð¾Ð²ÑÐ¹ ÑÑÐ¸Ñ
ÐºÐ°ÑÐ±Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ñ
ÐºÑÐ¸Ð¾ÐºÐ¾Ð½ÑÐµÑÐ²Ð°ÑÐ¸Ñ
Ð¿Ð¸ÑÐ¾Ð¼ÐµÐ»Ð»Ð¸ÑÐ¾Ð²ÑÐ¹ Ð´Ð¸Ð°Ð½Ð³Ð¸Ð´ÑÐ¸Ð´
ÑÐºÐ°Ð½ÐµÐ²Ð°Ñ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ
ÑÐºÐ°Ð½ÐµÐ¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÐ¹ ÑÐ¾ÑÑÐ´Ð¸ÑÑÑÐ¹ Ð¸Ð¼Ð¿Ð»Ð°Ð½Ñ
ÑÑÐ¸ÑÑÐ¸Ð»Ð°Ð¼Ð¸Ð½
ÑÐ³Ð»ÐµÑÐ¾Ð´Ð½ÑÐµ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ½Ð°
ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ðµ
aromatic polyimide
carbon nanofibers
carbonization
cryopreservation
diaminodiphenyl ether
electrospinning
pyromellitic dianhydride
tissue engineering
tissue-engineered vascular implant
triethylamine
water-soluble polyamic acid salts

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description: This work reports on development and characterization of electrospun nonwoven materials based on aromatic polyimides for tissue engineering applications, namely cell storage and cryopreservation, conductive scaffolds, and tissue-engineered vascular grafts. Properties of aqueous solutions of polyamic acid salts based on 1,2,4,5-benzenetetracarboxylic acid dianhydride and 4,4'-diaminodiphenyl ether were investigated. Electrospinning, imidization, and carbonization regimes were developed. In vitro and in vivo biocompatibility tests were held on human dermal fibroblasts culture and experimental animals, respectively. The possibility of using polyimide and carbon matrices as substrates for cell storage, including long-term cryopreservation, was confirmed. Inflammatory reaction was noted; so additional tests are required to proof implantation safety. The possibility of using polyimide nonwoven materials as non-biodegradable tissue-engineering vascular implants has been studied. Hemocompatibility and sufficient strength of tubular samples were confirmed.