cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: PET-CT versus MRI in the identification of hepatic metastases from colorectal carcinoma: An evidence based review of the current literature.
Creators: name: Power, Stephen
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Liver
subject: Oncology
subject: MR
subject: PET-CT
subject: PET
subject: Comparative studies
subject: Diagnostic procedure
subject: Outcomes analysis
subject: Metastases
subject: Neoplasia
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: This poster aims to summarise the latest available literature regarding the identification of hepatic metastases from colorectal carcinoma using PET-CT and MRI. Colorectal carcinoma affects an average of 150000 patients globally each year. The liver...
Excel@Carolina Summer Research Presentation: Engaging Adolescents and Young Adults with Cancer via a Social Support App (Lazard)
Creators: name: Varma, Tushar
name: Lazard, Allison
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Working with the principal investigator and associate professor at the UNC Hussman School of Journalism & Media, Allison Lazard, Ph.D., and team, I served as a research assistant during the summer of 2020 in effort to find ways to facilitate meaningful connections on peer-to-peer social support apps for adolescents and young adults (AYA) with cancer. An often underserved and neglected population, AYAs with cancer tend to struggle to find the appropriate support they need, which can lead to feelings of isolation and inadequate mental health. Many AYAs wish they had found online support way before they did. After analyzing 45 AYA interviews, Lazard and the team have compiled primary findings that can be summarized in this presentation and brief for advocacy groups (designed and co-written by me).

This project has received grant funding through the American Cancer Society, as identified below:

American Cancer Society (ACS) 133694-PEP-19-154-01-PCSM. “Engaging Adolescents and Young Adults with Cancer via a Social Support App.” $144,000. 11% Effort in Years 1-2.
title: Granulomatous Mastitis; Can it be a Radiological Diagnosis?
Creators: name: Sadec, Hoda
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Cancer
subject: Computer Applications-Detection, diagnosis
subject: Abscess delineation
subject: Ultrasound
subject: MR
subject: Mammography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -To be familiar with different imaging appearance of Idiopathic granulomatous mastitis. -To demonstrate the role of imaging in diagnosis and management of this unusual...
Using Records About Slavery Tutorial: A Project of the Wilson Special Collections Library
Creators: name: Neuroth, Lydia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Archival research
Manuscripts
Information literacy
Access to archives
History--Research--Archival resources

description: This paper describes the development of an online tutorial designed to help undergraduate students conduct research using archival collections about slavery and to navigate to and within those collections to find pertinent information to their research topic. This tutorial was designed specifically for researching collections in the Southern Historical Collection (SHC) in the Wilson Special Collections Library at UNC Chapel Hill. This project aimed to address a very specific need: to support novice users researching slavery or enslaved people. The paper explains the challenges associated with conducting archival research on slavery and describes the ways in which other institutions have aimed to solve this problem. A literature review discusses the merits of using tutorials in a library setting to support information literacy needs. The creation of the tutorial is described in brief. The paper concludes with an evaluative study with undergraduates using a survey to solicit their feedback and a discussion of changes based upon those results.
title: Uncommon sites of breast cancer metastases: Imaging Findings
Creators: name: Aouini, Rim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Contrast agent-intravenous
subject: MR
subject: CT
subject: Oncology
subject: Breast
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate the imaging findings of uncommon breast cancer (BC) metastatic sites, based on a review of eleven histopathologically proved...
Disconnected contributions to the spin of the nucleon
Creators: name: Chambers, A. J.
name: Horsley, R.
name: Nakamura, Y.
name: Perlt, H.
name: Pleiter, D.
name: Rakow, P. E. L.
name: Schierholz, G.
name: Schiller, A.
name: Stüben, H.
name: Young, R. D.
name: Zanotti, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The spin decomposition of the proton is a long-standing topic of much interest in hadronic physics. Lattice QCD has had much success in calculating the connected contributions to the quark spin. However, complete calculations, which necessarily involve gluonic and strange-quark contributions, still present some challenges. These "disconnected" contributions typically involve small signals hidden against large statistical backgrounds and rely on computationally intensive stochastic techniques. In this work we demonstrate how a Feynman-Hellmann approach may be used to calculate such quantities, by measuring shifts in the proton energy arising from artificial modifications to the QCD action. We find a statistically significant non-zero result for the disconnected quark spin contribution to the proton of about -5% at a pion mass of 470 MeV.
Studio e Sviluppo di Tecniche Fotografiche per la Documentazione, Conservazione e lo Studio della Collezione dei Papiri Carbonizzati di Ercolano nel Contesto del Progetto Greekschools
Creators: name: Pavone, Danilo Paolo
name: Caliri, Claudia
name: Romano, Francesco Paolo
name: Miliani, Costanza
name: Ranocchia, Graziano
Publisher: name: Zenodo
Year: 2022
Subjects: Technical Photography, Herculaneum papyri

description: A survey of the imaging campaigns on Herculaneum papyri thourgh technical photography performed between September 2021 and July 2022
(101841) Josephine Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Studio e Sviluppo di Tecniche Fotografiche per la Documentazione, Conservazione e lo Studio della Collezione dei Papiri Carbonizzati di Ercolano nel Contesto del Progetto Greekschools
Creators: name: Pavone, Danilo Paolo
Publisher: name: Zenodo
Year: 2022
Subjects: Technical Photography, Herculaneum papyri

description: A survey of the imaging campaigns on Herculaneum papyri thourgh technical photography performed between September 2021 and July 2022
A numerical method to solve the Stokes problem with a punctual force in source term
Creators: name: Lacouture, Loïc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The aim of this note is to present a numerical method to solve the Stokes problem in a bounded domain with a Dirac source term, which preserves optimality for any approximation order by the finite-element method. It is based on the knowledge of a fundamental solution to the associated operator over the whole space. This method is motivated by the modeling of the movement of active thin structures in a viscous fluid.
description: Comptes Rendus M{\'e}canique, Elsevier, 2015, http://www.sciencedirect.com/science/article/pii/S1631072114001818
title: Prognostic value of radiological findings for mortality in idiopathic normal pressure hydrocephalus
Creators: name: Kojoukhova, Maria
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Dementia
subject: Shunts
subject: MR
subject: CT
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: It is known that some radiological features are both associated with diagnosis of idiopathic normal pressure hydrocephalus (iNPH) and improvement of symptoms after shunt surgery. However, little is known about the relationship between radiological...
Cosmic axion background propagation in galaxies
Creators: name: Day, Francesca V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Many extensions of the Standard Model include axions or axion-like particles (ALPs). Here we study ALP to photon conversion in the magnetic field of the Milky Way and starburst galaxies. By modelling the effects of the coherent and random magnetic fields, the warm ionized medium and the warm neutral medium on the conversion process, we simulate maps of the conversion probability across the sky for a range of ALP energies. In particular, we consider a diffuse cosmic ALP background (CAB) analogous to the CMB, whose existence is suggested by string models of inflation. ALP-photon conversion of a CAB in the magnetic fields of galaxy clusters has been proposed as an explanation of the cluster soft X-ray excess. We therefore study the phenomenology and expected photon signal of CAB propagation in the Milky Way. We find that, for the CAB parameters required to explain the cluster soft X-ray excess, the photon flux from ALP-photon conversion in the Milky Way would be unobservably small. The ALP-photon conversion probability in galaxy clusters is 3 orders of magnitude higher than that in the Milky Way. Furthermore, the morphology of the unresolved cosmic X-ray background is incompatible with a significant component from ALP-photon conversion. We also consider ALP-photon conversion in starburst galaxies, which host much higher magnetic fields. By considering the clumpy structure of the galactic plasma, we find that conversion probabilities comparable to those in clusters may be possible in starburst galaxies.
description: Version accepted by Physics Letters B
Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients
Creators: name: Picchi, M.A.
name: Randell, S.
name: Tesfaigzi, Y.
name: Tessema, M.
name: Petersen, H.
name: Yingling, C.M.
name: Wu, G.
name: Belinsky, S.A.
name: Lin, Y.
name: Do, K.
name: Tassew, D.D.
Publisher: name: Elsevier Ireland Ltd
Year: 2020

description: Objectives: Smoking is a common risk factor for chronic obstructive pulmonary disease (COPD) and lung cancer. Although COPD patients have higher risk of lung cancer compared to non-COPD smokers, the molecular links between these diseases are not well-defined. This study aims to identify genes that are downregulated by cigarette smoke and commonly repressed in COPD and lung cancer. Materials and methods: Primary human airway epithelial cells (HAEC) were exposed to cigarette-smoke-extract (CSE) for 10-weeks and significantly suppressed genes were identified by transcriptome array. Epigenetic abnormalities of these genes in lung adenocarcinoma (LUAD) from patients with or without COPD were determined using genome-wide and gene-specific assays and by in vitro treatment of cell lines with trichostatin-A or 5-aza-2-deoxycytidine. Results: The ten most commonly downregulated genes following chronic CSE exposure of HAEC and show promoter hypermethylation in LUAD were selected. Among these, expression of CCNA1, SNCA, and ZNF549 was significantly reduced in lung tissues from COPD compared with non-COPD cases while expression of CCNA1 and SNCA was further downregulated in tumors with COPD. The promoter regions of all three genes were hypermethylated in LUAD but not normal or COPD lungs. The reduced expression and aberrant promoter hypermethylation of these genes in LUAD were independently validated using data from the Cancer Genome Atlas project. Importantly, SNCA and ZNF549 methylation detected in sputum DNA from LUAD (52% and 38%) cases were more prevalent compared to cancer-free smokers (26% and 15%), respectively (p < 0.02). Conclusions: Our data show that suppression of CCNA1, SNCA, and ZNF549 in lung cancer and COPD occurs with or without promoter hypermethylation, respectively. Detecting methylation of these and previously identified genes in sputum of cancer-free smokers may serve as non-invasive biomarkers for early detection of lung cancer among high risk smokers including COPD patients.
High fidelity ac gate operations of the quantum dot hybrid qubit
Creators: name: Wong, Clement H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Semiconductor quantum dots in silicon are promising qubits because of long spin coherence times and their potential for scalability. However, such qubits with complete electrical control and fidelities above the threshold for quantum error correction have not yet been achieved. We show theoretically that the threshold fidelity can be achieved with ac gate operation of the quantum dot hybrid qubit. Formed by three electrons in a double dot, this qubit is electrically controlled, does not require magnetic fields, and runs at GHz gate speeds. We analyze the decoherence caused by 1/f charge noise in this qubit, find the parameter regime for tunnel couplings and detuning that minimize the charge noise dependence in the qubit frequency, and determine the optimal working points for ac gate operations that drive the detuning and tunnel coupling.
Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction
Creators: name: Matthias, N.
name: Harris, A.
name: Sorscher, E.J.
name: Mendel, M.
name: Davis, B.R.
name: Anirudhan, V.
name: Barillà, C.
name: Rab, A.
name: Crane, A.M.
name: Randell, S.H.
name: Kerschner, J.L.
name: Suzuki, S.
name: Kim, K.
name: Zhang, L.
name: Yin, S.
name: Conway, A.
Publisher: name: Cell Press
Year: 2020

description: There is a strong rationale to consider future cell therapeutic approaches for cystic fibrosis (CF) in which autologous proximal airway basal stem cells, corrected for CFTR mutations, are transplanted into the patient's lungs. We assessed the possibility of editing the CFTR locus in these cells using zinc-finger nucleases and have pursued two approaches. The first, mutation-specific correction, is a footprint-free method replacing the CFTR mutation with corrected sequences. We have applied this approach for correction of ΔF508, demonstrating restoration of mature CFTR protein and function in air-liquid interface cultures established from bulk edited basal cells. The second is targeting integration of a partial CFTR cDNA within an intron of the endogenous CFTR gene, providing correction for all CFTR mutations downstream of the integration and exploiting the native CFTR promoter and chromatin architecture for physiologically relevant expression. Without selection, we observed highly efficient, site-specific targeted integration in basal cells carrying various CFTR mutations and demonstrated restored CFTR function at therapeutically relevant levels. Significantly, Omni-ATAC-seq analysis revealed minimal impact on the positions of open chromatin within the native CFTR locus. These results demonstrate efficient functional correction of CFTR and provide a platform for further ex vivo and in vivo editing. © 2020 The American Society of Gene and Cell TherapySuzuki et al. report correction of the CFTR defect in cystic fibrosis airway basal stem cells. They utilized gene-editing strategies either specific for the ΔF508 CFTR mutation or applicable to most CFTR mutations. Both approaches yielded highly efficient correction without selection, restoring CFTR function to therapeutically relevant levels.
Anomalous Dimensions of Heavy Operators from Magnon Energies
Creators: name: Koch, Robert de Mello
name: Tahiridimbisoa, Nirina Hasina
name: Mathwin, Christopher
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study spin chains with boundaries that are dual to open strings suspended between systems of giant gravitons and dual giant gravitons. The anomalous dimensions computed in the gauge theory are in complete quantitative agreement with energies computed in the dual string theory. The comparison makes use of a description in terms of magnons, generalizing results for a single maximal giant graviton. The symmetries of the problem determine the structure of the magnon boundary reflection/scattering matrix up to a phase. We compute a reflection/scattering matrix element at weak coupling and verify that it is consistent with the answer determined by symmetry. We find the reflection/scattering matrix does not satisfy the boundary Yang-Baxter equation so that the boundary condition on the open spin chain spoils integrability. We also explain the interpretation of the double coset ansatz in the magnon language.
description: 48 pages. v2: references added, typos corrected
Fibrocyte accumulation in the lungs of cystic fibrosis patients
Creators: name: Clancy, J.P.
name: Kasam, R.K.
name: Courtney, J.A.
name: Kramer, E.L.
name: Randell, S.H.
name: Jegga, A.G.
name: Gajjala, P.R.
name: Madala, S.K.
Publisher: name: Elsevier B.V.
Year: 2020

description: Background: Cystic fibrosis (CF) patients develop severe lung disease including chronic airway infections, neutrophilic inflammation, and progressive fibrotic remodeling in airways. However, cellular and molecular processes that regulate excessive collagen deposition in airways in these patients remain unclear. Fibrocytes are bone marrow (BM)-derived mesenchymal cells that express the hematopoietic cell marker CD45, and mesenchymal cell markers and implicated in collagen deposition in several fibrotic diseases. It is unknown whether fibrocytes accumulate in the lungs of CF patients, so the current study evaluates the presence of fibrocytes in the fibrotic lesions of airways in explanted CF lungs compared to non-CF unused donor lungs (control). Methods: We used immunofluorescence staining to determine if fibrocytes accumulate in explanted CF lungs compared to healthy donor lungs. Simultaneously, we evaluated cells collected by bronchoalveolar lavage (BAL) in CF patients using multi-color flow cytometry. Finally, we analyzed transcripts differentially expressed in fibrocytes isolated from the explanted CF lungs compared to control to assess fibrocyte-specific pro-fibrotic gene networks. Results: Our findings demonstrate fibrocyte accumulation in CF lungs compared to non-CF lungs. Additionally, fibrocytes were detected in the BAL of all CF children. Transcriptomic analysis of fibrocytes identified dysregulated genes associated with fibrotic remodeling in CF lungs. Conclusions: With significantly increased fibrocytes that show increased expression of pro-fibrotic gene transcripts compared to control, our findings suggest an intervention for fibrotic remodeling as a potential therapeutic target in CF.
Additional file 1 of Streptomyces avermitilis MICNEMA2022: a new biorational strain for producing abamectin as an integrated nematode management agent
Creators: name: Radwan, Wafaa H.
name: Abdelhafez, Ahmed A. M.
name: Mahgoub, Ahmed E.
name: Zayed, Mona S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Supplementary Material 1
Nilpotent evolution algebras over arbitrary fields
Creators: name: Hegazi, A. S.
name: Abdelwahab, Hani
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 17D92, 17D99

description: The paper is devoted to the study of annihilator extensions of evolution algebras and suggests an approach to classify finite-dimensional nilpotent evolution algebras. Subsequently nilpotent evolution algebras of dimension up to four are classfied.
description: arXiv admin note: text overlap with arXiv:1312.4685 by other authors
title: Value of MRI in the assessment of cardiac sarcoidosis
Creators: name: Aouini, Rim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Contrast agents
subject: Thorax
subject: MR
subject: Computer Applications-Detection, diagnosis
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this exhibit is to illustrate the imaging features of cardiac sarcoidosis (CS) in Magnetic Resonance Imaging (MRI) and to outline the added value of late gadolinium enhancement (LGE) in the detection of both active and chronic phases of...
ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia
Creators: name: Pendergast, A.M.
name: Khatri, A.
name: Kraft, B.D.
name: Tata, P.R.
name: Randell, S.H.
name: Piantadosi, C.A.
Publisher: name: National Academy of Sciences
Year: 2019

description: Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of molecules that might be therapeutically targeted in response to infections to promote activation of progenitor cell types remains elusive. Here, we report that loss of Abl1 specifically in SCGB1A1-expressing cells leads to a significant increase in the proliferation and differentiation of bronchiolar epithelial cells, resulting in dramatic expansion of an SCGB1A1+ airway cell population that coexpresses SPC, a marker for type II alveolar cells that promotes alveolar regeneration following bacterial pneumonia. Furthermore, treatment with an Abl-specific allosteric inhibitor enhanced regeneration of the alveolar epithelium and promoted accelerated recovery of mice following pneumonia. These data reveal a potential actionable target that may be exploited for efficient recovery after pathogen-induced infections.
(101835) John Joseph Goodenough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway
Creators: name: Immormino, R.M.
name: Moran, T.P.
name: Balogh, P.A.
name: Randell, S.H.
name: Kulis, M.D.
name: Smeekens, J.M.
Publisher: name: Blackwell Publishing Ltd
Year: 2019

description: Background: There is growing evidence that environmental peanut exposure through non-oral routes, including the skin and respiratory tract, can result in peanut sensitization. Environmental adjuvants in indoor dust can promote sensitization to inhaled antigens, but whether they contribute to peanut allergy development is unclear. Objective: We investigated whether indoor dust promotes airway sensitization to peanut and peanut allergy development in mice. Methods: Female and male C57BL/6J mice were exposed via the airways to peanut, indoor dust extract, or both for 2 weeks. Mice were then challenged with peanut and assessed for anaphylaxis. Peanut-specific immunoglobulins, peanut uptake by lung conventional dendritic cells (cDCs), lung innate cytokines, and T cell differentiation in lung-draining lymph nodes were quantified. Innate cytokine production by primary human bronchial epithelial cells exposed to indoor dust was also determined. Results: Inhalational exposure to low levels of peanut in combination with indoor dust, but neither alone, resulted in production of peanut-specific IgE and development of anaphylaxis upon peanut challenge. Indoor dust triggered production of innate cytokines in murine lungs and in primary human bronchial epithelial cells. Additionally, inhaled indoor dust stimulated maturation and migration of peanut-laden lung type 1 cDCs to draining lymph nodes. Inhalational exposure to peanut and indoor dust induced peanut-specific T helper 2 cell differentiation and accumulation of T follicular helper cells in draining lymph nodes, which were associated with increased B cell numbers and peanut-specific immunoglobulin production. Conclusions & clinical relevance: Indoor dust promotes airway sensitization to peanut and development of peanut allergy in mice. Our findings suggest that environmental adjuvants in indoor dust may be determinants of peanut allergy development in children.
Antidamping spin-orbit torque driven by spin-flip reflection mechanism on the surface of a topological insulator: A time-dependent nonequilibrium Green function approach
Creators: name: Mahfouzi, Farzad
name: Nikolić, Branislav K.
name: Kioussis, Nicholas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Motivated by recent experiments observing spin-orbit torque (SOT) acting on the magnetization $\vec{m}$ of a ferromagnetic (F) overlayer on the surface of a three-dimensional topological insulator (TI), we investigate the origin of the SOT and the magnetization dynamics in such systems. We predict that lateral F/TI bilayers of finite length, sandwiched between two normal metal leads, will generate a large antidamping-like SOT per very low charge current injected parallel to the interface. The large values of antidamping-like SOT are {\it spatially localized} around the transverse edges of the F overlayer. Our analysis is based on adiabatic expansion (to first order in $\partial \vec{m}/\partial t$) of time-dependent nonequilibrium Green functions (NEGFs), describing electrons pushed out of equilibrium both by the applied bias voltage and by the slow variation of a classical degree of freedom [such as $\vec{m}(t)$]. From it we extract formulas for spin torque and charge pumping, which show that they are reciprocal effects to each other, as well as Gilbert damping in the presence of SO coupling. The NEGF-based formula for SOT naturally splits into four components, determined by their behavior (even or odd) under the time and bias voltage reversal. Their complex angular dependence is delineated and employed within Landau-Lifshitz-Gilbert simulations of magnetization dynamics in order to demonstrate capability of the predicted SOT to efficiently switch $\vec{m}$ of a perpendicularly magnetized F overlayer.
description: 11 pages, 6 figures
Cyclic compression increases F508 DEL CFTR expression in ciliated human airway epithelium
Creators: name: Rehman, S.
name: Seckler, J.
name: Gaston, B.
name: Davis, M.
name: Marozkina, N.
name: Periasamy, A.
name: Altawallbeh, G.
name: Randell, S.H.
name: Smith, L.
name: Gaston, H.
name: Bosch, J.
name: Cotton, C.
name: Schilz, R.
name: Zaman, K.
name: Jones, D.R.
Publisher: name: American Physiological Society
Year: 2019

description: The mechanisms by which transepithelial pressure changes observed during exercise and airway clearance can benefit lung health are challenging to study. Here, we have studied 117 mature, fully ciliated airway epithelial cell filters grown at air-liquid interface grown from 10 cystic fibrosis (CF) and 19 control subjects. These were exposed to cyclic increases in apical air pressure of 15 cmH2O for varying times. We measured the effect on proteins relevant to lung health, with a focus on the CF transmembrane regulator (CFTR). Immunofloures-cence and immunoblot data were concordant in demonstrating that air pressure increased F508Del CFTR expression and maturation. This effect was in part dependent on the presence of cilia, on Ca2+ influx, and on formation of nitrogen oxides. These data provide a mechanosensory mechanism by which changes in luminal air pressure, like those observed during exercise and airway clearance, can affect epithelial protein expression and benefit patients with diseases of the airways.
(101838) Winifred Alice Slack
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Challenges facing airway epithelial cell-based therapy for cystic fibrosis
Creators: name: Berical, A.
name: Hawkins, F.
name: Randell, S.H.
name: Lee, R.E.
Publisher: name: Frontiers Media S.A.
Year: 2019

description: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or absent functional CFTR protein in airway epithelial cells leads to abnormally viscous mucus and impaired mucociliary transport, resulting in bacterial infections and inflammation causing progressive lung damage. There are more than 2000 known variants in the CFTR gene. A subset of CF individuals with specific CFTR mutations qualify for pharmacotherapies of variable efficacy. These drugs, termed CFTR modulators, address key defects in protein folding, trafficking, abundance, and function at the apical cell membrane resulting from specific CFTR mutations. However, some CFTR mutations result in little or no CFTR mRNA or protein expression for which a pharmaceutical strategy is more challenging and remote. One approach to rescue CFTR function in the airway epithelium is to replace cells that carry a mutant CFTR sequence with cells that express a normal copy of the gene. Cell-based therapy theoretically has the potential to serve as a one-time cure for CF lung disease regardless of the causative CFTR mutation. In this review, we explore major challenges and recent progress toward this ambitious goal. The ideal therapeutic cell would: (1) be autologous to avoid the complications of rejection and immune-suppression; (2) be safely modified to express functional CFTR; (3) be expandable ex vivo to generate sufficient cell quantities to restore CFTR function; and (4) have the capacity to engraft, proliferate and persist long-term in recipient airways without complications. Herein, we explore human bronchial epithelial cells (HBECs) and induced pluripotent stem cells (iPSCs) as candidate cell therapies for CF and explore the challenges facing their delivery to the human airway.
title: Altered cardiac function and ECG in patients with myotonic dystrophies
Creators: name: Schmid, Johannes
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: MR
subject: Echocardiography
subject: Cardiac
subject: Genetic defects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Types 1 and 2 myotonic dystrophies (MD) are hereditary neuromuscular disorders with an increased risk for sudden cardiac death [1]. We aimed to describe changes in cardiac function and ECG in this patient...
Identification of an emphysema- associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts
Creators: name: Platig, J.
name: Cho, M.H.
name: Thannickal, V.J.
name: Randell, S.H.
name: Washko, G.
name: Silverman, E.K.
name: Hao, Y.
name: Chase, R.
name: Crapo, J.
name: Parker, M.M.
name: Zhou, X.
name: Hersh, C.P.
name: Castaldi, P.J.
name: Estépar, R.S.J.
name: Pham, B.
name: Guo, F.
Publisher: name: eLife Sciences Publications Ltd
Year: 2019

description: Murine studies have linked TGF-β signaling to emphysema, and human genome-wide association studies (GWAS) studies of lung function and COPD have identified associated regions near genes in the TGF-β superfamily. However, the functional regulatory mechanisms at these loci have not been identified. We performed the largest GWAS of emphysema patterns to date, identifying 10 GWAS loci including an association peak spanning a 200 kb region downstream from TGFB2. Integrative analysis of publicly available eQTL, DNaseI, and chromatin conformation data identified a putative functional variant, rs1690789, that may regulate TGFB2 expression in human fibroblasts. Using chromatin conformation capture, we confirmed that the region containing rs1690789 contacts the TGFB2 promoter in fibroblasts, and CRISPR/Cas-9 targeted deletion of a ~ 100 bp region containing rs1690789 resulted in decreased TGFB2 expression in primary human lung fibroblasts. These data provide novel mechanistic evidence linking genetic variation affecting the TGF-β pathway to emphysema in humans.
title: Χαρτογράφηση προγραμμάτων των χωρών της Ευρωπαϊκής Ένωσης για το περιβάλλον και την αγωγή υγείας σε σχολεία πρωτοβάθμιας εκπαίδευσης
title: Mapping of European Union programmes countries on environment and health education in primary schools
titleType: AlternativeTitle
Creators: name: Γεωργούλα, Χριστίνα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Περιβαλλοντική εκπαίδευση
Αγωγή υγείας
Βιωσιμότητα
Πρωτοβάθμια εκπαίδευση
Ευρωπαϊκή Ένωση

description: Η εξέλιξη της ανθρώπινης επιστήμης και τεχνολογίας μπορεί να εκτόξευσε την ποιότητα ζωής της ανθρωπότητας, όμως οι επιπτώσεις της ανθρώπινης δραστηριότητας στο περιβάλλον, έχει δημιουργήσει την ανάγκη για την καλύτερη εκπαίδευση των νέων, ειδικά, ανθρώπων στην αντιμετώπιση των περιβαλλοντικών ζητημάτων και την ανάπτυξη βιώσιμων συμπεριφορών και τρόπων ζωής. Στην παρούσα εργασία γίνεται μια προσπάθεια αποτύπωσης των εκπαιδευτικών προγραμμάτων σχετικά με την αγωγή υγείας και περιβάλλοντος, τόσο σε θεωρητικό επίπεδο, όσο και σε επίπεδο εφαρμογής στους κόλπους της Ε.Ε.. Με βάση την ανάγκη που προέκυψε για εκπαίδευση του ανθρώπινου πληθυσμού σε ζητήματα προστασίας του περιβάλλοντος και ειδικότερα στο πώς το περιβάλλον επηρεάζει την ανθρώπινη υγεία, γίνεται μια θεωρητική και πρακτική προσέγγιση της έννοιας της περιβαλλοντικής εκπαίδευσης και της αγωγής υγείας. Ειδικότερα, παρουσιάζεται μια εκτενής βιβλιογραφική έρευνα πάνω στα ζητήματα αυτά, πριν γίνει μια αποτύπωση της κατάστασης σε μια σειρά από χώρες της Ε.Ε.. Με βάση τα παραπάνω, τα βασικά συμπεράσματα που προκύπτουν είναι ότι τα προγράμματα αγωγής υγείας και περιβάλλοντος στην Ε.Ε. χαρακτηρίζονται από μία πολυποικιλότητα. Η Ε.Ε. θα πρέπει συλλογικά να ασχοληθεί πιο επιτακτικά με τη δημιουργία ενός σαφούς, συνεχούς, συνεκτικού και στοχευμένου πλάνου αναφορικά με την αγωγή περιβάλλοντος και υγείας.
Additional file 3 of Streptomyces avermitilis MICNEMA2022: a new biorational strain for producing abamectin as an integrated nematode management agent
Creators: name: Radwan, Wafaa H.
name: Abdelhafez, Ahmed A. M.
name: Mahgoub, Ahmed E.
name: Zayed, Mona S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Supplementary Material 3
(101832) Rowland Thomson Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1–Like Ocular Disease in Mice
Creators: name: Esther, C.R., Jr.
name: Davis, R.M.
name: Paulsen, F.
name: Burns, K.A.
name: Dang, H.
name: Yu, D.
name: Wang, Y.
name: Saini, Y.
name: Chen, G.
name: Randell, S.H.
name: Boucher, R.C.
name: Ghio, A.J.
Publisher: name: Elsevier Inc.
Year: 2018

description: Human subjects with pseudohypoaldosteronism-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction. A conditional βENaC MG knockout (KO) mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and associated ocular surface disease. βENaC MG KO mice exhibited a striking age-dependent, female-predominant MG dysfunction phenotype, with white toothpaste–like secretions observed obstructing MG orifices at 7 weeks of age. There were compensatory increases in tear production but higher tear sodium and indexes of mucin concentration in βENaC MG KO mice. Histologically, MG acinar atrophy was observed with ductal enlargement and ductal epithelial hyperstratification. Inflammatory cell infiltration was observed in both MG and conjunctiva of βENaC MG KO mice. In older βENaC MG KO mice (5 to 11 months), significant ocular surface pathologies were noted, including corneal opacification, ulceration, neovascularization, and ectasia. Inflammation in MG and conjunctiva was confirmed by increased cytokine gene and protein expression and positive Ly-6B.2 immunostaining. Cell proliferation assays revealed lower proliferation rates of MG cells derived from βENaC MG KO than control mice, suggesting that βENaC plays a role in cell renewal of mouse MG. Loss of βENaC function resulted in MG disease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 MG disease and was sex dependent.
Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease
Creators: name: Carpenter, J.
name: Tarran, R.
name: Terryah, S.T.
name: Randell, S.H.
name: Arendshorst, W.J.
name: Kim, C.S.
name: Sesma, J.I.
name: Reidel, B.
name: Fellner, R.C.
name: Garland, A.L.
name: Sabater, J.R.
name: Kesimer, M.
name: Moore, P.J.
name: Abraham, W.M.
name: Scott, D.W.
name: Ahmad, S.
Publisher: name: American Physiological Society
Year: 2018

description: In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection, and lung damage. Inhibition of ENaC is an attractive therapeutic option. However, ENaC antagonists have failed clinically because of off-target effects in the kidney. The S18 peptide is a naturally occurring short palate lung and nasal epithelial clone 1 (SPLUNC1)-derived ENaC antagonist that restores airway surface liquid height for up to 24 h in CF human bronchial epithelial cultures. However, its efficacy and safety in vivo are unknown. To interrogate the potential clinical efficacy of S18, we assessed its safety and efficacy using human airway cultures and animal models. S18-mucus interactions were tested using superresolution microscopy, quartz crystal microbalance with dissipation, and confocal microscopy. Human and murine airway cultures were used to measure airway surface liquid height. Off-target effects were assessed in conscious mice and anesthetized rats. Morbidity and mortality were assessed in the β-ENaC-transgenic (Tg) mouse model. Restoration of normal mucus clearance was measured in cystic fibrosis transmembrane conductance regulator inhibitor 172 [CFTR(inh)-172]-challenged sheep. We found that S18 does not interact with mucus and rapidly penetrated dehydrated CF mucus. Compared with amiloride, an early generation ENaC antagonist, S18 displayed a superior ability to slow airway surface liquid absorption, reverse CFTR(inh)-172-induced reduction of mucus transport, and reduce morbidity and mortality in the β-ENaC-Tg mouse, all without inducing any detectable signs of renal toxicity. These data suggest that S18 is the first naturally occurring ENaC antagonist to show improved preclinical efficacy in animal models of CF with no signs of renal toxicity.
(101836) Isabella Goodenough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Benign bone tumors with malignant imaging features
Creators: name: HERAZO, CHERINA
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Cancer
subject: Education
subject: MR
subject: CT
subject: Conventional radiography
subject: Musculoskeletal system
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the imaging features of some benign tumors that can simulate malignant etiology in radiology To present occasionalbone destruction and soft tissue patterns that can be found in benign...
Αξιοποίηση του λογισμικού Scratch Jr για την ανάπτυξη δεξιοτήτων υπολογιστικής σκέψης στην Α’ Δημοτικού
Creators: name: Ριμπά, Αναστασία Μαρία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Computational thinking
subject: ScratchJr
subject: K-12
subject: Math
subject: Project based learning

description: Η διπλωματική εργασία που ακολουθεί αφορά τη δημιουργία ενός διδακτικού σεναρίου για την ανάπτυξη δεξιοτήτων Υπολογιστικής Σκέψης και Μαθηματικών στην Α’ Δημοτικού. Το κύριο εργαλείο που χρησιμοποιείται είναι το Scratch Jr. Το διδακτικό σενάριο που προτείνεται βασίστηκε στις αρχές του Project Based Learning, οι εκπαιδευτικοί στόχοι διατυπώθηκαν με βάση την αναθεωρημένη ταξινομία του Bloom των εκπαιδευτικών στόχων, ενώ χρησιμοποιήθηκε και η ρουτίνα Use-Modify-Create για την κατανόηση βασικών εννοιών προγραμματισμού. Για τη συλλογή των δεδομένων χρησιμοποιήθηκαν τεστ-κριτήρια αξιολόγησης για τους μαθητές, και ένα ερωτηματολόγιο για τους εκπαιδευτικούς. Η ανάλυση των δεδομένων πραγματοποιήθηκε με ποσοτικές μεθόδους της περιγραφικής και επαγωγικής στατιστικής. Το διδακτικό σενάριο αξιολογήθηκε θετικά ως προς τη χρησιμότητα και την δομή του από 25 εκπαιδευτικούς, ενώ παρατηρήθηκε υψηλότερη βαθμολογία ως προς τη χρησιμότητα από τους εκπαιδευτικούς που έχουν ξαναδιδάξει σε Α’ και Β’ Δημοτικού. Παρατηρήθηκαν σημαντικές βελτιώσεις στις δεξιότητες Υπολογιστικής Σκέψης και Μαθηματικών στους μαθητές στους οποίους εφαρμόστηκε το διδακτικό σενάριο, με την βελτίωση στην Υπολογιστική Σκέψη να είναι σημαντικότερη από τη βελτίωση στα Μαθηματικά.
Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells
Creators: name: Harris, A.
name: Gillen, A.E.
name: Perez, A.
name: Leir, S.-H.
name: Yang, R.
name: Cotton, C.U.
name: Randell, S.H.
Publisher: name: Elsevier B.V.
Year: 2018

description: Background: Robust methods to culture primary airway epithelial cells were developed several decades ago and these cells provide the model of choice to investigate many diseases of the human lung. However, the molecular signature of cells from different regions of the airway epithelium has not been well characterized. Methods: We utilize DNase-seq and RNA-seq to examine the molecular signatures of primary cells derived from human tracheal and bronchial tissues, as well as healthy and diseased (cystic fibrosis (CF)) donor lung tissue. Results: Our data reveal an airway cell signature that is divergent from other epithelial cell types and from common airway epithelial cell lines. The differences between tracheal and bronchial cells are clearly evident as are common regulatory features. Only minor variation is seen between bronchial cells from healthy or CF donors. Conclusions: These data are a valuable resource for functional genomics analysis of airway epithelial tissues in human disease.
Καθ' οδόν προς την υιοθέτηση του ePrivacy. Η προς ρύθμιση ύλη και τα διακυβεύματα του νέου κανονιστικού πλαισίου
Creators: name: Παπαντώνη, Ηλιάνα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Ιδιωτικότητα
subject: Επικοινωνίες
subject: Απόρρητο
subject: ePrivacy
subject: Ηλεκτρονικές επικοινωνίες
subject: Μεταδεδομένα
subject: Cookies
subject: Τερματικός εξοπλισμός
subject: Διαθέσιμοι στο κοινό κατάλογοι

description: Ανάλυση του Κανονισμού ePrivacy "για τον σεβασμό της ιδιωτικής ζωής και την προστασία των δεδομένων προσωπικού χαρακτήρα στις ηλεκτρονικές επικοινωνίες και την κατάργηση της οδηγίας 2002/58/ΕΚ (κανονισμός για την ιδιωτική ζωή και τις ηλεκτρονικές επικοινωνίες". Ειδικότερη ανάλυση του δικαιώματος της ιδιωτικότητας σε συνάρτηση με το απόρρητο των επικοινωνιών υπό τον κίνδυνο των νέων τεχνολογιών, της ανάγκης προστασίας του απορρήτου μέσω ενός ενιαίου κανονιστικού πλαισίου, του προστατευτικού πλαισίου του Κανονισμού και του νομοθετικού κενού που έρχεται να καλύψει, των επιμέρους εννοιών που συναντώνται στο κείμενο του (μεταδεδομένα, cookies, τερματικός εξοπλισμός, διαθέσιμοι στο κοινό κατάλογοι κλπ.) και του λόγου μη ψήφισης του έως και σήμερα. Γίνεται, τέλος, συγκριτική επισκόπηση του πρώτου σχεδίου (πρόταση της Ευρωπαϊκής Επιτροπής) με το τελικό σχέδιο (το οποίο εγκρίθηκε από το Ευρωπαϊκό Συμβούλιο).