cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Note on the Validity of Cross-Validation for Evaluating Time Series Prediction
Creators: name: Bergmeir, Christoph
name: Hyndman, Rob J
name: Koo, Bonsoo
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: One of the most widely used standard procedures for model evaluation in classification and regression is K-fold cross-validation (CV). However, when it comes to time series forecasting, because of the inherent serial correlation and potential non-stationarity of the data, its application is not straightforward and often omitted by practitioners in favor of an out-of-sample (OOS) evaluation. In this paper, we show that the particular setup in which time series forecasting is usually performed using Machine Learning methods renders the use of standard K-fold CV possible. We present theoretical insights supporting our arguments. Furthermore, we present a simulation study where we show empirically that K-fold CV performs favourably compared to both OOS evaluation and other time-series-specific techniques such as non-dependent cross-validation.
A Bayesian alternative to mutual information for the hierarchical clustering of dependent random variables
Creators: name: Marrelec, Guillaume
name: Messé, Arnaud
name: Bellec, Pierre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: The use of mutual information as a similarity measure in agglomerative hierarchical clustering (AHC) raises an important issue: some correction needs to be applied for the dimensionality of variables. In this work, we formulate the decision of merging dependent multivariate normal variables in an AHC procedure as a Bayesian model comparison. We found that the Bayesian formulation naturally shrinks the empirical covariance matrix towards a matrix set a priori (e.g., the identity), provides an automated stopping rule, and corrects for dimensionality using a term that scales up the measure as a function of the dimensionality of the variables. Also, the resulting log Bayes factor is asymptotically proportional to the plug-in estimate of mutual information, with an additive correction for dimensionality in agreement with the Bayesian information criterion. We investigated the behavior of these Bayesian alternatives (in exact and asymptotic forms) to mutual information on simulated and real data. An encouraging result was first derived on simulations: the hierarchical clustering based on the log Bayes factor outperformed off-the-shelf clustering techniques as well as raw and normalized mutual information in terms of classification accuracy. On a toy example, we found that the Bayesian approaches led to results that were similar to those of mutual information clustering techniques, with the advantage of an automated thresholding. On real functional magnetic resonance imaging (fMRI) datasets measuring brain activity, it identified clusters consistent with the established outcome of standard procedures. On this application, normalized mutual information had a highly atypical behavior, in the sense that it systematically favored very large clusters. These initial experiments suggest that the proposed Bayesian alternatives to mutual information are a useful new tool for hierarchical clustering.
Forecasting Compositional Time Series: A State Space Approach
Creators: name: Snyder, Ralph D.
name: Ord, J. Keith
name: Koehler, Anne B.
name: McLaren, Keith R.
name: Beaumont, Adrian
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: A method is proposed for forecasting composite time series such as the market shares for multiple brands. Its novel feature is that it relies on multi-series adaptations of exponential smoothing combined with the log-ratio transformation for the conversion of proportions onto the real line. It is designed to produce forecasts that are both non-negative and sum to one; are invariant to the choice of the base series in the log-ratio transformation; recognized and exploit features such as serial dependence and non-stationary movements in the data; allow for the possibility of non-uniform interactions between the series; and contend with series that start late, finish early, or which have values close to zero. Relying on an appropriate multivariate innovations state space mode, it can be used to generate prediction distributions in addition to point forecasts and to compute the probabilities of market share increases together with prediction intervals. A shared structure between the series in the multivariate model is used to ensure that the usual proliferation of parameter is avoided. The forecasting method is illustrated using data on the annual market shares of the major (groups of) brands in the U.S. automobile market, over the period 1961-2013.
Excess of heme induces tissue factor-dependent activation of coagulation in mice
Creators: name: Key, N. S.
name: Gailani, D.
name: Wang, S.
name: Mackman, N.
name: Sparkenbaugh, E. M.
name: Jonas, W.
name: Pawlinski, R.
name: Kirchhofer, D.
name: Kasthuri, R.
name: Gruber, A.
name: Chantrathammachart, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activation in wild-type mice that was attenuated by an anti-tissue factor antibody and in mice expressing low levels of tissue factor. In contrast, neither factor XI deletion nor inhibition of factor XIIa-mediated factor XI activation reduced heme-induced coagulation activation, suggesting that the intrinsic coagulation pathway is not involved. We investigated the source of tissue factor in heme-induced coagulation activation. Heme increased the procoagulant activity of mouse macrophages and human PBMCs. Tissue factor-positive staining was observed on leukocytes isolated from the blood of heme-treated mice but not on endothelial cells in the lungs. Furthermore, heme increased vascular permeability in the mouse lungs, kidney and heart. Deletion of tissue factor from either myeloid cells, hematopoietic or endothelial cells, or inhibition of tissue factor expressed by non-hematopoietic cells did not reduce heme-induced coagulation activation. However, heme-induced activation of coagulation was abolished when both non-hematopoietic and hematopoietic cell tissue factor was inhibited. Finally, we demonstrated that coagulation activation was partially attenuated in sickle cell mice treated with recombinant hemopexin to neutralize free heme. Our results indicate that heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo. We also demonstrated that free heme may contribute to thrombin generation in a mouse model of sickle cell disease.
Curvature and the c-projective mobility of Kaehler metrics with hamiltonian 2-forms
Creators: name: Calderbank, David M. J.
name: Matveev, Vladimir S.
name: Rosemann, Stefan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53B35, 53C55, 53B10, 53A20, 32J27, 53C25

description: The mobility of a Kaehler metric is the dimension of the space of metrics with which it is c-projectively equivalent. The mobility is at least two if and only if the Kaehler metric admits a nontrivial hamiltonian 2-form. After summarizing this relationship, we present necessary conditions for a Kaehler metric to have mobility at least three: its curvature must have nontrivial nullity at every point. Using the local classification of Kaehler metrics with hamiltonian 2-forms, we describe explicitly the Kaehler metrics with mobility at least three and hence show that the nullity condition on the curvature is also sufficient, up to some degenerate exceptions. In an Appendix, we explain how the classification may be related, generically, to the holonomy of a complex cone metric.
description: 19 pages, refereed version - this differs from the final published version, to appear in Compositio Mathematica
Spectro-photometric distances to stars: a general-purpose Bayesian approach
Creators: name: Santiago, Basílio X.
name: Brauer, Dorothée E.
name: Anders, Friedrich
name: Chiappini, Cristina
name: Queiroz, Anna B.
name: Girardi, Léo
name: Rocha-Pinto, Helio J.
name: Balbinot, Eduardo
name: da Costa, Luiz N.
name: Maia, Marcio A. G.
name: Schultheis, Mathias
name: Steinmetz, Matthias
name: Miglio, Andrea
name: Montalbán, Josefina
name: Schneider, Donald P.
name: Beers, Timothy C.
name: Frinchaboy, Peter M.
name: Lee, Young Sun
name: Zasowski, Gail
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We developed a code that estimates distances to stars using measured spectroscopic and photometric quantities. We employ a Bayesian approach to build the probability distribution function over stellar evolutionary models given these data, delivering estimates of model parameters for each star individually. The code was first tested on simulations, successfully recovering input distances to mock stars with <1% bias.The method-intrinsic random distance uncertainties for typical spectroscopic survey measurements amount to around 10% for dwarf stars and 20\% for giants, and are most sensitive to the quality of $\log g$ measurements. The code was validated by comparing our distance estimates to parallax measurements from the Hipparcos mission for nearby stars (< 300 pc), to asteroseismic distances of CoRoT red giant stars, and to known distances of well-studied open and globular clusters. The external comparisons confirm that our distances are subject to very small systematic biases with respect to the fundamental Hipparcos scale (+0.4 % for dwarfs, and +1.6% for giants). The typical random distance scatter is 18% for dwarfs, and 26% for giants. For the CoRoT-APOGEE sample, the typical random distance scatter is ~15%, both for the nearby and farther data. Our distances are systematically larger than the CoRoT ones by about +9%, which can mostly be attributed to the different choice of priors. The comparison to known distances of star clusters from SEGUE and APOGEE has led to significant systematic differences for many cluster stars, but with opposite signs, and with substantial scatter. Finally, we tested our distances against those previously determined for a high-quality sample of giant stars from the RAVE survey, again finding a small systematic trend of +5% and an rms scatter of 30%.
description: 30 pages, 9 figures. Approved for publication
Probabilistic time series forecasting with boosted additive models: an application to smart meter data
Creators: name: Taieb, Souhaib Ben
name: Huser, Raphael
name: Hyndman, Rob J.
name: Genton, Marc G.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: A large body of the forecasting literature so far has been focused on forecasting the conditional mean of future observations. However, there is an increasing need for generating the entire conditional distribution of future observations in order to effectively quantify the uncertainty in time series data. We present two different methods for probabilistic time series forecasting that allow the inclusion of a possibly large set of exogenous variables. One method is based on forecasting both the conditional mean and variance of the future distribution using a traditional regression approach. The other directly computes multiple quantiles of the future distribution using quantile regression. We propose an implementation for the two methods based on boosted additive models, which enjoy many useful properties including accuracy, flexibility, interpretability and automatic variable selection. We conduct extensive experiments using electricity smart meter data, on both aggregated and disaggregated scales, to compare the two forecasting methods for the challenging problem of forecasting the distribution of future electricity consumption. The empirical results demonstrate that the mean and variance forecasting provides better forecasts for aggregated demand, while the flexibility of the quantile regression approach is more suitable for disaggregated demand. These results are particularly useful since more energy data will become available at the disaggregated level in the future.
Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia
Creators: name: Zeidner, J. F.
name: Little, R. F.
name: Foster, M. C.
name: Karp, J. E.
name: Wright, J. J.
name: Litzow, M. R.
name: Gojo, I.
name: Levy, M. Y.
name: Bose, P.
name: Doyle, L. A.
name: Rosner, G. L.
name: Morris, L. E.
name: Smith, B. D.
name: Tibes, R.
name: Gocke, C. D.
name: Lancet, J. E.
name: Blackford, A. L.
name: Strickland, S. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Serial studies have demonstrated that induction therapy with FLAM [flavopiridol (alvocidib) 50 mg/m2 days 1–3, cytarabine 667 mg/m2/day continuous infusion days 6–8, and mitoxantrone (FLAM) 40 mg/m2 day 9] yields complete remission rates of nearly 70% in newly diagnosed poor-risk acute myeloid leukemia. Between May 2011–July 2013, 165 newly diagnosed acute myeloid leukemia patients (age 18–70 years) with intermediate/adverse-risk cytogenetics were randomized 2:1 to receive FLAM or 7+3 (cytarabine 100 mg/m2/day continuous infusion days 1–7 and daunorubicin 90 mg/m2 days 1–3), across 10 institutions. Some patients on 7+3 with residual leukemia on day 14 received 5+2 (cytarabine 100 mg/m2/day continuous infusion days 1–5 and daunorubicin 45 mg/m2 days 1–2), whereas patients on FLAM were not re-treated based on day 14 bone marrow findings. The primary objective was to compare complete remission rates between one cycle of FLAM and one cycle of 7+3. Secondary end points included safety, overall survival and event-free survival. FLAM led to higher complete remission rates than 7+3 alone (70% vs. 46%; P=0.003) without an increase in toxicity, and this improvement persisted after 7+3+/−5+2 (70% vs. 57%; P=0.08). There were no significant differences in overall survival and event-free survival in both arms but post-induction strategies were not standardized. These results substantiate the efficacy of FLAM induction in newly diagnosed AML. A phase III study is currently in development. This study is registered with clinicaltrials.gov identifier: 01349972.
Minimal paths between communities induced by geographical networks
Creators: name: de Arruda, Henrique Ferraz
name: Comin, Cesar Henrique
name: Costa, Luciano da Fontoura
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In this work we investigate the betweenness centrality in geographical networks and its relationship with network communities. We show that vertices with large betweenness define what we call characteristic betweenness paths in both modeled and real-world geographical networks. We define a geographical network model that possess a simple topology while still being able to present such betweenness paths. Using this model, we show that such paths represent pathways between entry and exit points of highly connected regions, or communities, of geographical networks. By defining a new network, containing information about community adjacencies in the original network, we describe a means to characterize the mesoscale connectivity provided by such characteristic betweenness paths.
Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide
Creators: name: Van Cott, K. E.
name: Nichols, T. C.
name: Velander, W. H.
name: Monahan, P. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Haemophilia replacement factors, both plasma-derived and recombinant, are in relatively short supply and are high-cost products. This has stymied the study and development of alternative methods of administration of haemophilia therapy even in the most economically advanced countries, owing to the large amounts of material needed because bioabsorption and bioavailability of haemophilic factors can be less than 10% when using non-intravenous routes of delivery. There is therefore a need to increase access to therapy worldwide by decreasing the cost and increasing the abundance so that therapy can be achieved through simplified, alternative delivery methods. Transgenic livestock have been used to produce haemophilic factors in milk. Only the pig mammary gland has been shown to carry out the post-translational processing necessary to enable both the biological activity and long circulation half-life needed for therapeutic glycoproteins. Furthermore, the large amounts of recombinant protein that can be produced from pig milk make feasible the use of alternative delivery methods such as oral, intratracheal, subcutaneous, and intramuscular administration.
Young Lives, Interrupted: Short-Term Effects of the COVID-19 Pandemic on Adolescents in Low- and Middle-Income Countries
Creators: name: Favara, Marta
name: Freund, Richard
name: Porter, Catherine
name: Sanchez, Alan
name: Scott, Douglas
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy

description: We examine the situation of adolescents during the COVID-19 pandemic in four low- and middle-income countries using data from a large-scale phone survey conducted in 2020. The survey was part of Young Lives, a 20-year longitudinal study of two cohorts of young people born in 1994 and 2001 in Ethiopia, India (Andhra Pradesh and Telangana), Peru and Vietnam. We focus on the Younger (19-year-old) Cohort, describing their experiences along multiple dimensions, and assessing how their lives have changed since an earlier survey in 2016. We also compare these young people with an Older Cohort (surveyed at the same age in 2013), using a cross-cohort comparison in the spirit of a difference-in-differences approach. Compared to 2016, and compared with the Older Cohort, the increase in the probability of a loss of household livelihood (income or employment) is both large and significant in all countries. However, a 2020 downturn in self-reported well-being is significant in Ethiopia, India and Peru, but not in Vietnam, the country which experienced particular success in controlling the pandemic during 2020.
STR: A Seasonal-Trend Decomposition Procedure Based on Regression
Creators: name: Dokumentov, Alexander
name: Hyndman, Rob J.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: We propose new generic methods for decomposing seasonal data: STR (a Seasonal-Trend decomposition procedure based on Regression) and Robust STR. In some ways, STR is similar to Ridge Regression and Robust STR can be related to LASSO. Our new methods are much more general than any alternative time series decomposition methods. They allow for multiple seasonal and cyclic components, and multiple linear regressors with constant, flexible, seasonal and cyclic influence. Seasonal patterns (for both seasonal components and seasonal regressors) can be fractional and flexible over time; moreover they can be either strictly periodic or have a more complex topology. We also provide confidence intervals for the estimated components, and discuss how STR can be used for forecasting.
Gusty, gaseous flows of FIRE: galactic winds in cosmological simulations with explicit stellar feedback
Creators: name: Muratov, Alexander L.
name: Keres, Dusan
name: Faucher-Giguere, Claude-Andre
name: Hopkins, Philip F.
name: Quataert, Eliot
name: Murray, Norman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an analysis of the galaxy-scale gaseous outflows from the FIRE (Feedback in Realistic Environments) simulations. This suite of hydrodynamic cosmological zoom simulations resolves formation of star-forming giant molecular clouds to $z=0$, and features an explicit stellar feedback model on small scales. Our simulations reveal that high redshift galaxies undergo bursts of star formation followed by powerful gusts of galactic outflows that eject much of the ISM and temporarily suppress star formation. At low redshift, however, sufficiently massive galaxies corresponding to L*-progenitors develop stable disks and switch into a continuous and quiescent mode of star formation that does not drive outflows far into the halo. Mass-loading factors for winds in L*-progenitors are $η\approx 10$ at high redshift, but decrease to $η\ll 1$ at low redshift. Although lower values of $η$ are expected as halos grow in mass over time, we show that the strong suppression of outflows with decreasing redshift cannot be explained by mass evolution alone. Circumgalactic outflow velocities are variable and broadly distributed, but typically range between one and three times the circular velocity of the halo. Much of the ejected material builds a reservoir of enriched gas within the circumgalactic medium, some of which could be later recycled to fuel further star formation. However, a fraction of the gas that leaves the virial radius through galactic winds is never regained, causing most halos with mass $M_h \le 10^{12} M_{\odot}$ to be deficient in baryons compared to the cosmic mean by $z=0$.
description: 24 pages, 12 figures, accepted to MNRAS
A phase II prospective open-label escalating dose trial of recombinant interleukin-11 in mild von Willebrand disease
Creators: name: RAGNI, M. V.
name: NICHOLS, T. C.
name: CHAPMAN, H. L.
name: JANKOWITZ, R. C.
name: DILLOW, A. M.
name: MERRICKS, E. P.
name: KLOOS, M. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: von Willebrand factor (VWF) is a multimeric glycoprotein that mediates platelet adhesion and is decreased in von Willebrand disease (VWD). 1-8 deamino-d-arginine vasopressin (DDAVP), the most common treatment for VWD, is limited by tachyphylaxis and inconvenience, and in 20% of the patients, unresponsiveness. Recombinant human interleukin-11 (rhIL-11), a gp-130 signalling cytokine with haematopoietic and anti-inflammatory activity, increases VWF antigen and its activity in heterozygous VWF+/− mice and dogs. To determine the biological efficacy and safety of rhIL-11 in non-bleeding human subjects with mild VWD, we conducted a phase II prospective open-label trial of rhIL-11 at 10, 25 and 50 μg kg−1 subcutaneously (s.c.), given daily for 7 days in nine subjects with mild VWD. VWF and factor VIII (FVIII) levels increased gradually and progressively after s.c. rhIL-11, which was sustained through 7 days of dosing to 1.5- to 3-fold over baseline. Following intravenous DDAVP, 0.3 μg kg−1, on day 7 there was a further boost in VWF and FVIII levels, suggesting that the mechanism of rhIL-11 differs from that of DDAVP. Platelet VWF mRNA expression measured by quantitative PCR increased from two- to eightfold over baseline, suggesting that the mechanism of rhIL-11 effect may be upregulation of VWF mRNA. VWF and FVIII levels returned to baseline by day 14. rhIL-11 was well tolerated with less than grade-1 hypertension, hypokalaemia and fluid retention. Recombinant IL-11 increases VWF levels in humans with mild VWD, justifying future clinical trials to determine its potential in preventing or reducing bleeding in this patient population.
A Mehta-Ramanathan theorem for linear systems with basepoints
Creators: name: Graf, Patrick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Let $(X, H)$ be a normal complex projective polarized variety and $\mathscr E$ an $H$-semistable sheaf on $X$. We prove that the restriction $\mathscr E\big|_C$ to a sufficiently positive general complete intersection curve $C \subset X$ passing through a prescribed finite set of points $S \subset X$ remains semistable, provided that at each $p \in S$, the variety $X$ is smooth and the factors of a Jordan-Hölder filtration of $\mathscr E$ are locally free. As an application, we obtain a generalization of Miyaoka's generic semipositivity theorem.
description: Mostly minor changes. Improved Example 1.9. To appear in Mathematische Nachrichten
Familial deficiency of vitamin K-dependent clotting factors: VITAMIN K-DEPENDENT CLOTTING FACTORS
Creators: name: WESTON, B. W.
name: MONAHAN, P. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Combined deficiency of vitamin K–dependent clotting factors II, VII, IX, and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose. A rare inherited form of defective γ-carboxylation resulting in early onset of bleeding was first described by McMillan and Roberts in 1966 and subsequently has been termed vitamin K–dependent clotting factor deficiency (VKCFD). Biochemical and molecular studies identify 2 variants of this autosomal recessive disorder: VKCFD1, which is associated with point mutations in the γ-glutamylcarboxylase gene (GGCX), and VKCFD2, which results from point mutations in the vitamin K epoxide reductase gene (VKOR). Bleeding ranges in severity from mild to severe. Therapy includes high oral doses of vitamin K for prophylaxis, usually resulting in partial correction of factor deficiency, and episodic use of plasma infusions. Recent molecular studies have the potential to further our understanding of vitamin K metabolism, γ-carboxylation, and the functional role this posttranslational modification has for other proteins. The results may also provide potential targets for molecular therapeutics and pharmacogenetics.
แนวทางการเพิ่มคุณภาพการให้บริการของธุรกิจนำเที่ยวในประเทศไทย
Creators: name: บุษศิดี อัครวงศ์วิภาส
Publisher: name: ชมรมวิทยาลัยนวัตกรรมการจัดการ
Year: 2022
Subjects: คุณภาพการให้บริการ
ธุรกิจนำเที่ยว
ประเทศไทย

description: วารสารวิชาการ การจัดการภาครัฐและเอกชน, 4, 2, 180-195
Nebria (Patrobonebria) himalayica Bates 1889
Creators: name: Huber, Charles
name: Baur, Hannes
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria himalayica

description:  Nebria (Patrobonebria) himalayica BATES, 1889 = N. macrocephala BREIT, 1914, nec MOTSCHULSKY, 1844 Type material examined. N. himalayica: Lectotype male, Goorais Valley, May 1887, J. H. Leech [printed label] // himalayica Bates [handwritten label] // Ex Musaeo H. W. Bates 1892 [printed label] // Museum Paris, ex. Coll. R. Oberthur [printed label] // Lectotype [red printed label] (MNHP) N. macrocephala: Syntypes 2 males, 1 female, Type [printed red label] // Po-o, SW Thibet [printed] // Nebria macrocephala n. sp. Breit [handwritten] // ex Orig. Sammlung J. Breit Wien [printed] (NMB). N. macrocephala pallidipes: Holotype male, Type [printed red label] // Po-o, SW Thibet [printed] // Nebria macrocephala n. sp. Breit [handwritten] // ex Orig. Sammlung J. Breit Wien [printed] // pallidipes Breit a. macrocephala Brt. [handwritten] (NMB).
description: Published as part of Charles Huber & Hannes Baur, 2016, Nebria (Patrobonebria) incognita n. sp. and Nebria (P.) hiekeiana n. sp., two new species from the Western Himalaya, with remarks on Nebria (P.) desgodinsi (Coleoptera, Carabidae, Nebriinae), pp. 203-214 in Entomologische Blätter und Coleoptera 112 (1) on page 213, DOI: 10.5281/zenodo.247616
Customer Satisfaction
Company Image
Brand Equity and Repurchase Intention: A Case Study of Starbucks Coffee Corporation in Bangkok Business District during the Impact of Covid-19
Creators: name: Jirangrug Samarkjarn
Publisher: name: Asian Administration and Management Review
Year: 2022
Subjects: Brand Equity
Company Image
Customer Satisfaction
Repurchase Intention

description: Asian Administration and Management Review, 5, 1, 72-84
Consistent Estimation in Large Heterogeneous Panels with Multifactor Structure Endogeneity
Creators: name: Forchini, G.
name: Jiang, Bin
name: Peng, Bin
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: The set-up considered by Pesaran (Econometrica, 2006) is extended to allow for endogenous explanatory variables. A class of instrumental variables estimators is studied and it is shown that estimators in this class are consistent and asymptotically normally distributed as both the cross-section and time-series dimensions tend to infinity.
Septic arthritis in males with haemophilia
Creators: name: FORSYTH, A.
name: MICHAEL SOUCIE, J.
name: ASHRANI, A. A.
name: GERAGHTY, S.
name: KEY, N. S.
name: DUFFY, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We used data collected as part of the Universal Data Collection (UDC) surveillance project in haemophilia treatment centers (HTC) to study the incidence, risk factors, and impact of septic arthritis among males with haemophilia. Patients participating in UDC on 2 or more occasions were included. Cases were defined as patients with documented joint infection. Characteristics of the cases were compared with those of haemophilia patients without infection. Among the 8026 eligible patients with 36,015 person-years of follow-up, 30 (0.37%) had a documented joint infection (incidence rate 83 per 100,000 person-years). In a logistic regression model, only increasing age (OR = 6.1 for age ≥30), race/ethnicity other than white (OR = 3.9), presence of inhibitor (OR = 3.9), invasive procedure in the past year (OR = 2.7) and presence of one or more target joints (OR = 3.2) remained statistically significant. CVAD use and HCV and HIV infection were not associated with septic arthritis risk after adjusting for potential confounders. Study limitations include possible underestimation of septic arthritis rate in this population and its retrospective design. We conclude that septic arthritis is an uncommon complication of haemophilia occurring primarily in joints most affected by bleeding and reparative surgical interventions.
The Data used for the study on the relationship between Yanshan movement and theYanliao Biota
Creators: name: Ma, Chao
Publisher: name: figshare
Year: 2019
Subjects: subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 40299 Geochemistry not elsewhere classified
subject: 49999 Earth Sciences not elsewhere classified

description: This repository contains one dataset and several MATLAB codes used for the study on the relationship between Yanshan movement and theYanliao Biota.
title:  My heart feels like it is swallowing itself. Approche argumentative et textométrique des émotions dans le slam américain
Creators: name: Bendinelli, Marion
name: Mathis , Elvire
Publisher: name: Roma TrE-Press
Year: 2020

description: Poesia violenta nata negli anni ’80 a Chicago, lo slam privilegia la rivendicazione di sé e la resistenza ai mali della società; esso si definisce come una pratica discorsiva intrinsicamente multimodale, situata all’intersezione tra lo scritto e l’orale. Una perfomance slam riunisce poeti e pubblico intorno alla condivisione di un vissuto, di una testimonianza, di un’impressione: questi racconti fittizi o reali commuovono, toccano, fanno (re)agire il pubblico. Le emozioni, siano esse espresse, evocate o suggerite da una configurazione lessicale o discorsiva, sono centrali. Il nostro lavoro intende identificare i marcatori d’emozione presenti nello slam e analizzarne i modi di semiotizzazione privilegiate dai poeti. Situandoci nel quadro dell’analisi semio-discorsiva e argomentativa delle emozioni, opteremo per un approccio testometrico dei corpus testuali al fine di reperire i suddetti marcatori e interrogarne il funzionamento discorsivo nell’ambito dei testi. Il nostro corpus comprende 72 performances di slam in inglese, messi in rete su YouTube nel 2017 dal collettivo americano Button Poetry. Ogni slam è nel formato XML-TEI affinché le trascrizioni possano tener conto delle caratteristiche prosodiche e cinesiche degli slams. L’esplorazione del corpus permette di mettere in luce i marcatori lessicali, retorici e comportamentali (la gestualità) che costituiscono a loro volta delle tracce dirette o indirette delle emozioni che abbiano contabilizzato, classificato e analizzato secondo la loro funzione argomentativa. La nostra analisi mostra così l’interesse di un approccio strumentale e interdisciplinare (semiolinguistica, argomentazione, testometria), dimostrando allo stesso tempo tutto il potenziale delle analisi che incrociano dati quantitativi e qualitativi.
description: Médias et émotions. Catégories d’analyses, problématiques, concepts
Forecasting hierarchical and grouped time series through trace minimization
Creators: name: Wickramasuriya, Shanika L
name: Athanasopoulos, George
name: Hyndman, Rob J
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Large collections of time series often have aggregation constraints due to product or geographical hierarchies. The forecasts for the disaggregated series are usually required to add up exactly to the forecasts of the aggregated series, a constraint known as “aggregate consistency”. The combination forecasts proposed by Hyndman et al. (2011) are based on a Generalized Least Squares (GLS) estimator and require an estimate of the covariance matrix of the reconciliation errors (i.e., the errors that arise due to aggregate inconsistency). We show that this is impossible to estimate in practice due to identifiability conditions.
Animal models of FVIIa gene expression: their role in the future development of haemophilia treatment
Creators: name: OBERGFELL, A.
name: EZBAN, M.
name: NICHOLS, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The development of inhibitors to replacement factor therapy is a serious complication in the treatment of patients with haemophilia and requires use of bypassing agents to prevent uncontrolled bleeding. The efficacy of recombinant factor VIIa (rFVIIa) as a bypassing agent in patients with haemophilia has been demonstrated in case studies and clinical trials. However, the perception of a short plasma half-life and consequent need for repeated daily injections means that long-term prophylaxis could potentially be limiting. Canine haemophilia models using a gene transfer approach have been used to evaluate the continuous expression of FVIIa in dogs. These studies show improvement in measurable bleeding parameters that have important clinical ramifications for patients with haemophilia. The combination of gene transfer as the method of delivery and FVII as the transgene overcomes issues associated with the short plasma half-life of rFVIIa, and represents a potentially attractive novel approach to haemostasis in patients with haemophilia and other platelet disorders.
Panel data segmentation under finite time horizon
Creators: name: Torgovitski, Leonid
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62G05, 62G20

description: We study the nonparametric change point estimation for common changes in the means of panel data. The consistency of estimates is investigated when the number of panels tends to infinity but the sample size remains finite. Our focus is on weighted denoising estimates, involving the group fused LASSO, and on the weighted CUSUM estimates. Due to the fixed sample size, the common weighting schemes do not guarantee consistency under (serial) dependence and most typical weightings do not even provide consistency in the i.i.d. setting when the noise is too dominant. Hence, on the one hand, we propose a consistent covariance-based extension of existing weighting schemes and discuss straightforward estimates of those weighting schemes. The performance will be demonstrated empirically in a simulation study. On the other hand, we derive sharp bounds on the change to noise ratio that ensure consistency in the i.i.d. setting for classical weightings.
description: Most important changes and corrections are explained at the beginning of the .tex file
Mechanically-driven spreading of bacterial populations
Creators: name: Ngamsaad, Waipot
name: Suantai, Suthep
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The effect of mechanical interactions between cells in the spreading of bacterial populations was investigated in one-dimensional space. A continuum-mechanics approach, comprising cell migration, proliferation, and exclusion processes, was employed to elucidate the dynamics. The consequent nonlinear reaction-diffusion-like equation describes the constitution dynamics of a bacterial population. In this model, bacterial cells were treated as rod-like particles that interact with each other through hard-core repulsion, which introduces the exclusion effect that causes bacterial populations to migrate quickly and at high density. The propagation of bacterial density as a traveling wave front over extended times was also analysed. The analytical and numerical solutions revealed that the front speed was enhanced by the exclusion process, which depended upon the cell-packing fraction. Finally, we qualitatively compared our theoretical results with experimental evidence.
description: 16 pages, 3 figures, Accepted for publication in Communications in Nonlinear Science and Numerical Simulation
Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs
Creators: name: KARPF, D. M.
name: AGERSØ, H.
name: NICHOLS, T. C.
name: DEFRIESS, N.
name: KJALKE, M.
name: EZBAN, M.
name: THIM, L.
name: MERRICKS, E. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: N8, a new recombinant factor VIII (rFVIII) compound developed for the treatment of haemophilia A, is produced in Chinese hamster ovary (CHO) cells and formulated without human- or animal-derived materials. The aim of the present study was to compare the pharmacokinetics (PK) and the procoagulant effect, measured by ex vivo whole blood clot formation, of N8 and a commercial rFVIII in a cross-over study in haemophilia A dogs. N8 and Advate® (100 IU kg−1) were administered intravenously to three haemophilia A dogs. Blood was sampled between 0 and 120 h postdose and FVIII:C analysed. PK parameters maximum plasma concentration, area under the curve, half-life (t½), clearance, mean residence time (MRT) and volume of distribution and incremental recovery were calculated. Whole blood clotting time (WBCT) and thromboelastography (TEG®) were used to determine the haemostatic potential. No adverse reactions were observed with N8 or Advate®. N8 and Advate® exhibited similar PK parameters, with t½ 7.7–11 h and MRT 11–14 h. Both rFVIII compounds corrected the prolonged WBCT (>48 min) to the range of normal dogs (8–12 min), i.e. N8 to 7.5–10.5 min and Advate® to 7.5–11.5 min. N8 and Advate® also normalized the whole blood clot formation according to TEG®. The native whole blood clotting assays (WBCT, TEG®) appeared to be more sensitive to low concentrations of FVIII than assays in citrated plasma samples. In conclusion, comparison of N8 and Advate® in haemophilia A dogs revealed similar safety, similar PK and similar effects in whole blood clot formation assays.
Contact Angle Adjustment in Equation of States Based Pseudo-Potential Model
Creators: name: Hu, Anjie
name: Li, Longjian
name: Uddin, Rizwan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: 76T10

description: Single component pseudo-potential lattice Boltzmann model has been widely applied in multiphase simulation due to its simplicity and stability. In many research, it has been claimed that this model can be stable for density ratios larger than 1000, however, the application of the model is still limited to small density ratios when the contact angle is considered. The reason is that the original contact angle adjustment method influences the stability of the model. Moreover, simulation results in present work show that, by applying the contact angle adjustment method, the density distribution near the wall is artificially changed, and the contact angle is dependent on the surface tension. Hence, it is very inconvenient to apply this method with a fixed contact angle, and the accuracy of the model cannot be guaranteed. To solve these problems, a contact angle adjustment method based on the geometry analysis is proposed and numerically compared with the original method. Simulation results show that, with the new contact angle adjustment method, the stability of the model is highly improved when the density ratio is relatively large, and it is independent of the surface tension.
description: 9 figures
Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog: RECOMBINANT CANINE FVIIA PK/PD
Creators: name: KRISTENSEN, A. T.
name: TRANHOLM, M.
name: AGERSØ, H.
name: NICHOLS, T. C.
name: EZBAN, M.
name: KJALKE, M.
name: JENSEN, A. L.
name: KNUDSEN, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Recombinant human FVIIa (rhFVIIa) corrects the coagulopathy in hemophilia A and B as well as FVII deficiency. This is also the case in dogs until canine anti-human FVIIa antibodies develop (~2 weeks). Recombinant canine factor VIIa (rcFVIIa), successfully over-expressed by gene transfer in haemophilia dogs, has provided long-term haemostasis (>2 years). However, pharmacokinetics (PK), pharmacodynamics (PD) and safety of rcFVIIa after pharmacological administration have not been reported. We therefore wanted to explore the safety, PK and PD of rcFVIIa in dogs. A pilot study was set up to evaluate the safety as well as PK and PD of rcFVIIa after a single intravenous dose of 270 μg kg−1 to one HA and one haemostatically normal dog and to directly compare rcFVIIa with rhFVIIa in these two dogs. Single doses of rcFVIIa and rhFVIIa were well tolerated. No adverse events were observed. Pharmacokinetic characteristics including half-life (FVIIa activity: 1.2–1.8 h; FVIIa antigen 2.8–3.7 h) and clearance were comparable for rcFVIIa and rhFVIIa. Kaolin-activated thromboelastography approached normal in the HA dog with the improvement being most pronounced after rcFVIIa. This study provided the first evidence that administering rcFVIIa intravenously is feasible, safe, well tolerated and efficacious in correcting the haemophilic coagulopathy in canine HA and that rcFVIIa exhibits pharmacokinetic characteristics comparable to rhFVIIa in haemophilic and haemostatically competent dogs. This strengthens the hypothesis that rcFVIIa can be administered to dogs to mimic the administration of rhFVIIa to humans.
EXPERIMENTAL STUDY ON PERFORMANCE OF VARIOUS THERMAL INSULATION MATERIALS UNDER SEVERE TEMPERATURE CONDITIONS
Creators: name: Khoso, Salim
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400505
subject: Construction materials
classificationCode: 400507
subject: Fire safety engineering
classificationCode: 400510
subject: Structural engineering

description: During the current era, global warming has become an alarming issue resulting due to the rise in temperature around the globe. If the planet continues warming at such an accelerated rate, it would be difficult for people to live creating discomfort and a nearly challenging environment to survive. The plains of Pakistan are primarily tropical. During summer, the temperature soars beyond 50 0C in numerous parts of southern Pakistan, causing several causalities due to sunstroke and electric power load shedding during the summer season from May to August. The primary heat source inside a building is radiation due to direct sun exposure. Hence, it becomes necessary to adopt a new methodology to resist radiations passing inside the building through the roof providing comfort to the tenants. Efforts have been made to lower the room temperature and keep it within bearable limits by introducing new materials in concrete. Therefore, this research work aims to determine the performance of tiles with different materials as thermal insulation. White cement was used with the combination of marble dust, and ceramic powder separately during this investigation. Interesting results were obtained during the peak hours of temperature, where a temperature difference of 8ºC was attained. For example, while considering sandwiched 50 mm tiles (baked and unbaked), the top temperature was 48ºC, and the bottom temperature was 40ºC. The maximum temperature difference was found to be 13ºC when a total of 75 mm thick pure clay and baked clay tiles were used with a combination of white material tiles.
Forecasting with Temporal Hierarchies
Creators: name: Athanasopoulos, George
name: Hyndman, Rob J
name: Kourentzes, Nikolaos
name: Petropoulos, Fotios
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper introduces the concept of Temporal Hierarchies for time series forecasting. A temporal
Measured quantum transformation groupoids
Creators: name: Enock, Michel
name: Timmermann, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Operator Algebras (math.OA)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 46L89, 46L55, 58B32

description: In this article, when G is a locally compact quantum group, we associate to a braided-commutative G-Yetter-Drinfel'd algebra $(N,a,\hat{a})$ equipped with a normal faithful semi-finite weight verifying some appropriate condition, a structure of a measured quantum groupoid. The dual structure is then given by $(N,\hat{a},a)$. Examples are given, especially the situation of a quotient type co-ideal of a compact quantum group. This construction generalizes the standard construction of a transformation groupoid. Most of the results were announced by the second author in 2011, at a conference in Warsaw.
description: 52 pages
The Data used for the study on the relationship between Yanshan movement and theYanliao Biota
Creators: name: Ma, Chao
Publisher: name: figshare
Year: 2019
Subjects: subject: 49999 Earth Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 40299 Geochemistry not elsewhere classified
subject: 40308 Palaeontology (incl. Palynology)
subject: 40399 Geology not elsewhere classified

description: This repository contains one dataset and several MATLAB codes used for the study on the relationship between Yanshan movement and theYanliao Biota.