title: ÐÐ´Ð½Ð¾Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð½ÑÐ¹ Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼ Pro12Ala Ð³ÐµÐ½Ð° PPARy Ð¸ -308 G/A Ð³ÐµÐ½Ð° TNFÐ° Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ñ Ñ Ð¶ÐµÐ½ÑÐ¸Ð½ ÑÐµÐ¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ° ÑÐµÐ²ÐµÑÐ¾-Ð·Ð°Ð¿Ð°Ð´Ð½Ð¾Ð³Ð¾ ÑÐµÐ³Ð¸Ð¾Ð½Ð° Ð Ð¾ÑÑÐ¸Ð¸
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾Ð¿ÑÑÐ¾Ð²Ð°, ÐÐ»ÐµÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¶Ð¸ÑÐ¾Ð²Ð°Ñ ÑÐºÐ°Ð½Ñ
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð²
PPARy
TNFa
Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ½ÑÐµ Ð²Ð°ÑÐ¸Ð°Ð½ÑÑ
adipose tissue
gene expression
polymorphic variants

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐµ Ð°ÑÑÐ¾ÑÐ¸Ð°ÑÐ¸Ð¹ Ð¾Ð´Ð½Ð¾Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð½ÑÑ Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼Ð¾Ð² (ÐÐÐ) Pro12Ala Ð³ÐµÐ½Ð° PPARÎ³ Ð¸ -308G/A Ð³ÐµÐ½Ð° TNFÎ± Ñ ÑÐ¸ÑÐºÐ¾Ð¼ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ñ ÑÑÐµÐ´Ð¸ Ð¶ÐµÐ½ÑÐ¸Ð½ ÑÐµÐ¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ°. Ð ÑÐ¾Ð´Ðµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ñ Ð´Ð°Ð½Ð½ÑÐµ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ Ð¾ Ð¿ÑÐ¸ÑÐ¸Ð½Ð°Ñ, ÑÑÐ¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ñ, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐºÑÐ¸Ð½Ð¸Ð½Ð³ ÐÐÐ Pro12Ala PPARÎ³ Ð¸ -308G/A TNFÎ± Ð² Ð³ÑÑÐ¿Ð¿Ðµ Ð¶ÐµÐ½ÑÐ¸Ð½ ÑÐµÐ¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ° Ñ Ð¸Ð·Ð±ÑÑÐ¾ÑÐ½ÑÐ¼ Ð²ÐµÑÐ¾Ð¼ Ð¸ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½ÑÐ¼ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ Ð¸ Ð² Ð³ÑÑÐ¿Ð¿Ðµ Ð¶ÐµÐ½ÑÐ¸Ð½ ÑÐµÐ¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ° Ñ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð°ÑÑÐ¾Ð¹ ÑÐµÐ»Ð° (ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ). Ð¡Ð¾Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐ°ÑÑÐ¾ÑÑ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð¾Ð² Ð¿Ð¾ ÐÐÐ Pro12Ala Ð³ÐµÐ½Ð° PPARÎ³ Ð¸ Ð¿Ð¾ ÐÐÐ -308G/A Ð³ÐµÐ½Ð° TNFÎ± Ð² Ð³ÑÑÐ¿Ð¿Ðµ Ð¶ÐµÐ½ÑÐ¸Ð½ Ñ Ð¸Ð·Ð±ÑÑÐ¾ÑÐ½ÑÐ¼ Ð²ÐµÑÐ¾Ð¼ Ð¸ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½ÑÐ¼ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ Ð¸ Ð² Ð³ÑÑÐ¿Ð¿Ðµ Ð¶ÐµÐ½ÑÐ¸Ð½ Ñ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð°ÑÑÐ¾Ð¹. ÐÑÐµÐ½ÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ¾Ð² ÐÐÐ Pro12Ala Ð³ÐµÐ½Ð° PPARÎ³ Ð¸ -308G/A Ð³ÐµÐ½Ð° TNFÎ± Ð½Ð° Ð°Ð½ÑÑÐ¾Ð¿Ð¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¸ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð½Ð° ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² PPARÎ³ Ð¸ TNFÎ± Ð² Ð¸Ð½ÑÑÐ°Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¶Ð¸ÑÐ¾Ð²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð² Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÑ Ð³ÑÑÐ¿Ð¿Ð°Ñ.
description: Work is devoted to assessing the association of single nucleotide polymorphisms (SNPs) Pro12Ala PPARÎ³ gene and -308G/A TNFa gene with risk of abdominal obesity among women of reproductive age. During the the work were examined literature data on the causes, etiology and pathogenesis of of abdominal obesity, screened SNPs Pro12Ala PPARÎ³ and -308G/A TNFÎ± in the group of women of childbearing age are overweight and abdominal obesity in a group of women of reproductive age with normal body weight were studied ( control). We compared the frequency of genotypes at SNPs Pro12Ala PPARÎ³ gene and SNPs -308G/A TNFÎ± gene in the group of women with overweight and abdominal obesity in a group of women with normal weight. We were examined effect of SNP variants of the Pro12Ala PPARÎ³ gene and -308G/A TNFÎ± gene on anthropometric and clinical indicators, and on the level of the PPARÎ³ and TNFÎ± gene expression in intraabdominal adipose tissue in the test groups.