cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer
Creators: name: Wang, Chenxing
name: Aikemu, Batuer
name: Shao, Yanfei
name: Zhang, Sen
name: Yang, Guang
name: Hong, Hiju
name: Huang, Ling
name: Jia, Hongtao
name: Yang, Xiao
name: Zheng, Minhua
name: Sun, Jing
name: Li, Jianwen
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary fig. 1. A- B TMB of the low and high MTOR expression groups was compared with different cancer cohorts in TCGA. Every dot represents a sample, and the red horizontal lines represent the median numbers of mutations in the respective cancer types. C- D Differences in the proportions of affected pathways between the low and high MTOR expression groups. TMB, tumor mutational burden; TCGA, The Cancer Genome Atlas.
The World Food Supply; A Partial List of References, 1925-1939
Creators: name: Olcott, Margaret T.
name: Olcott, Margaret T.
Publisher: name: Unknown
Year: 1939
Subjects: Agricultural and Food Policy
Crop Production/Industries
Food Consumption/Nutrition/Food Safety
Food Security and Poverty
International Relations/Trade
Livestock Production/Industries

description: Excerpts from the Foreword: This bibliography is supplementary to World Food Supply; A Selected Bibliography published in June 1925 as Bibliographical Contributions No. 9 of the Library of the U.S. Department of Agriculture. The outbreak of the European War in September 1939 created a demand for recent references on the world's supply of foodstuffs and raw materials. This bibliography is arranged geographically: first, references on the world subdivided under general, economic geography, grain, nutrition, oils and fats, raw materials, and sugar; then alphabetically by continent, in most cases subdivided by country. The references under Germany, Great Britain and the United States are further subdivided by subject.
Factory of realities: on the emergence of virtual spatiotemporal structures
Creators: name: Zapatrin, Roman
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: The ubiquitous nature of modern Information Retrieval and Virtual World give rise to new realities. To what extent are these "realities" real? Which "physics" should be applied to quantitatively describe them? In this essay I dwell on few examples. The first is Adaptive neural networks, which are not networks and not neural, but still provide service similar to classical ANNs in extended fashion. The second is the emergence of objects looking like Einsteinian spacetime, which describe the behavior of an Internet surfer like geodesic motion. The third is the demonstration of nonclassical and even stronger-than-quantum probabilities in Information Retrieval, their use. Immense operable datasets provide new operationalistic environments, which become to greater and greater extent "realities". In this essay, I consider the overall Information Retrieval process as an objective physical process, representing it according to Melucci metaphor in terms of physical-like experiments. Various semantic environments are treated as analogs of various realities. The readers' attention is drawn to topos approach to physical theories, which provides a natural conceptual and technical framework to cope with the new emerging realities.
description: 21 pp
Moyers et al. Supplementary Materials from Feeder density enhances house finch disease transmission in experimental epidemics
Creators: name: Sahnzi C. Moyers
name: Adelman, James S.
name: Farine, Damien R.
name: Thomason, Courtney A.
name: Hawley, Dana M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 60801 Animal Behaviour

description: Combined supplementary methods and results
What we can learn from two-dimensional QCD-like theories at finite density
Creators: name: Wellegehausen, Björn H.
name: von Smekal, Lorenz
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study generic properties of strongly interacting matter at finite density as relevant to heavy-ion collisions at moderate beam energies or the physics of neutron stars and their mergers. Because of the fermion-sign problem in lattice QCD, here we simulate QCD-like theories without this problem at finite density. These theories (two-color QCD, G2-QCD, or adjoint QCD) typically contain bosonic baryons, for example diquarks, or other more exotic states of matter. It is therefore important to understand the effects of such bosonic matter and disentangle them from fermionic baryons where they exist to draw conclusions for QCD. Simulations of these theories, for instance G2-QCD, reveal an interesting and rich phase diagram at zero temperature. Many open questions arise, partly due to the lack of high precision or large volume/continuum data. This is the reason why we study two-dimensional QCD-like theories. In this contribution we shall discuss differences between QCD-like theories at baryon chemical and isospin chemical potential. Furthermore we present simulation results on the phase diagram and spectroscopy at finite density for G2- and two-color-QCD and compare it to free lattice fermions.
description: 7 pages, 6 figures, talk presented at the 34th annual International Symposium on Lattice Field Theory (Lattice2016), 24-30 July 2016, University of Southampton, UK
Neutron interference in the Earth's gravitational field
Creators: name: Galiautdinov, Andrei
name: Ryder, Lewis H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Popular Physics (physics.pop-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This work relates to the famous experiments, performed in 1975 and 1979 by Werner et al., measuring neutron interference and neutron Sagnac effects in the earth's gravitational field. Employing the method of Stodolsky in its weak field approximation, explicit expressions are derived for the two phase shifts, which turn out to be in agreement with the experiments and with the previously obtained expressions derived from semi-classical arguments: these expressions are simply modified by relativistic correction factors.
description: 7 pages, 1 figure
title: «Perché l’altro deve essere scoperto...». L’umanesimo di Todorov, tra critica della violenza e ibridazione culturale
Creators: name: Ruocco, Giovanni
Publisher: name: Università di Pisa
Year: 2018

description: À travers la lecture de la biographie et de l’œuvre entière de Todorov, dans sa reconstruction au cœur de l’histoire de la pensée, notamment française, d’une doctrine humaniste (illuministe, libérale et démocratique), l’article fixe la ligne intellectuelle et existentielle constamment suivie par l’écrivain franco-bulgare dans sa vie. En lisant cette perspective de recherche omme fondée sur trois piliers –l’autonomie du soi, la finalisation de l’action individuelle aux autres, et l’universalisation de l’humain –cette réflexion sur la pensée de Todorov se développe à partir de sa conviction que la nature humaine est sociale, c’est-à-dire qu’à l’origine de la constitution psychique, morale et culturelle de chaque individu il y a la relation avec l’autre. L’article vert notamment sur son analyse des relations humaines, surtout dans les rapports entre cultures, et sur l’importance pour lui de la notion d’hybridation, forme de rencontre réelle parmi les êtres humains.
description: Suite francaise: Pensare (con) Todorov, 1/2018
Supplementary Table S1 from Reviewing the effects of food provisioning on wildlife immunity
Creators: name: Strandin, Tomas
name: Babayan, Simon A.
name: Forbes, Kristian M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Table S1. Key aspects of captive and food restriction studies assessing the effects of food provisioning on immunity in wildlife species. References are listed in the main document.
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy
Creators: name: Li, Zhao
name: She, Tianshan
name: Yang, Hao
name: Su, Tao
name: Shi, Qiuxiao
name: Tao, Ze
name: Feng, Yanru
name: Yang, Fen
name: Cheng, Jingqiu
name: Lu, Xiaofeng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Multidrug resistance (MDR), which is common in colorectal cancer (CRC), induces high mortality in patients. Due to its robust and selective apoptosis induction in some CRC cells with MDR, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is attractive as a novel tool for CRC therapy. However, TRAIL is limited by its poor tumor-homing ability and inefficient apoptosis induction in CRC cells expressing low levels of death receptor (DR). Here, the tumor-homing RGR peptide (CRGRRST) was fused to TRAIL to produce RGR-TRAIL. Compared with TRAIL, RGR-TRAIL showed greater cell binding and cytotoxicity in CRC cells. In addition, RGR-TRAIL exerted significantly enhanced tumor uptake and growth suppression in mice bearing CRC tumor xenografts. Notably, RGR-TRAIL eradicated all tumor xenografts of DR-overexpressing COLO205 cells. However, TRAIL only showed mild tumor growth suppression under the same conditions, indicating that RGR fusion significantly increased the antitumor effect of TRAIL in DR-overexpressing CRC cells by improving tumor homing. Nevertheless, RGR fusion did not significantly enhance the antitumor effect of TRAIL in HT29 cells expressing low levels of DR. We found that DR expression in HT29 cells was enhanced by epidermal growth factor receptor (EGFR)-targeted photodynamic therapy (PDT). Moreover, both the in vitro and in vivo antitumor effects of RGR-TRAIL were significantly improved by combination with PDT. HT29 tumor xenografts (∼20%) were even eradicated by combination therapy. These results indicate that it is valuable to further evaluate the combination therapy of RGR-TRAIL and tumor-targeted PDT for clinical therapy of CRC with MDR.
War and Agriculture in the United States, 1914-1941; Selected References
Creators: name: Borg, Walter T.
name: Borg, Walter T.
Publisher: name: Unknown
Year: 1942
Subjects: Agricultural and Food Policy
Crop Production/Industries
Demand and Price Analysis
Food Consumption/Nutrition/Food Safety
Food Security and Poverty
Livestock Production/Industries

description: Excerpts: This bibliography is a selected list of references on the effects of World War I and the present crisis on agriculture. It consists of references to specific studies, articles in learned publications devoted to agriculture, government reports, and addresses and articles by policy makers of the United States Department of Agriculture. The references have been limited to those dealing specifically with war and agriculture or with phases of the subject. Included in the latter category are a few references to the nutrition program and its effect on agriculture. Material pertinent to specific topics may be found through the author and subject index which accompanies the bibliography.
Supplementary information;100-word summary from School is out on noisy reefs: the effect of boat noise on predator learning and survival of juvenile coral reef fishes
Creators: name: Ferrari, Maud C. O.
name: McCormick, Mark I.
name: Meekan, Mark G.
name: Simpson, Stephen D.
name: Nedelec, Sophie L.
name: Chivers, Douglas P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Supplementary information
Discovery of new TeV supernova remnant shells in the Galactic plane with H.E.S.S
Creators: name: Gottschall, D.
name: Capasso, M.
name: Deil, C.
name: Djannati-Atai, A.
name: Donath, A.
name: Eger, P.
name: Marandon, V.
name: Maxted, N.
name: Pühlhofer, G.
name: Renaud, M.
name: Sasaki, M.
name: Terrier, R.
name: Vink, J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Supernova remnants (SNRs) are prime candidates for efficient particle acceleration up to the knee in the cosmic ray particle spectrum. In this work we present a new method for a systematic search for new TeV-emitting SNR shells in 2864 hours of H.E.S.S. phase I data used for the H.E.S.S. Galactic Plane Survey. This new method, which correctly identifies the known shell morphologies of the TeV SNRs covered by the survey, HESS J1731-347, RX 1713.7-3946, RCW 86, and Vela Junior, reveals also the existence of three new SNR candidates. All three candidates were extensively studied regarding their morphological, spectral, and multi-wavelength (MWL) properties. HESS J1534-571 was associated with the radio SNR candidate G323.7-1.0, and thus is classified as an SNR. HESS J1912+101 and HESS J1614-518, on the other hand, do not have radio or X-ray counterparts that would permit to identify them firmly as SNRs, and therefore they remain SNR candidates, discovered first at TeV energies as such. Further MWL follow up observations are needed to confirm that these newly discovered SNR candidates are indeed SNRs.
Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy
Creators: name: Liu, Wan
name: Cheng, Meng
name: Lu, Zhiyang
name: Li, Haocheng
name: Feng, Yulin
name: Jin, Yi
name: Yang, Shilin
name: Feng, Jianfang
name: Tu, Liangxing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Neuroscience
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Modifying nanocrystals with functional materials have been common strategy to enlarge the enhancing ability on oral absorption via nanocrystals; however, whether the functional materials have played their full enhancing ability in oral absorption is still unknown. In this study, we synthetized a novel chitosan-based copolymer (the copolymer of sodium dodecyl sulfate (SDS), chitosan (CS) and D-α-Tocopherol polyethylene glycol 1000 succinate, SDS-CS-TPGS), and modified nanocrystals with this copolymer, aiming to enhance the oral absorption of polymer andrographolide (ADR). In real-time distribution study, we found the distribution of ADR, SDS, CS and TPGS varies in gastrointestinal tract, while the distribution of ADR and SDS-CS-TPGS was similar, revealing the SDS-CS-TPGS could able to participate in the absorption process of andrographolide timely. To explore the oral absorption enhancing ability of SDS-CS-TPGS, we prepared a series of nanocrystals modified with different materials and explored their pharmacokinetic performances on SD rats. The results showed the nanocrystals modified with SDS-CS-TPGS (S-C-TANs) exhibited the highest bioavailability, which could enhance the AUC0-∞ of ADR from 1.291 mg/L*h to 5.275 mg/L*h (enhanced for about 4.09-folds). The enhanced anti- inflammatory efficacy was also found on ICR mice by employing ear swelling rate, TNF-α, IL-1β and IL-6 and pharmacodynamic index. These results indicated that modified with synthesized copolymer containing different functional stabilizers is an efficient strategy to enlarge the enhancing ability on oral absorption of nanocrystals.
Casimir effect for Dirac lattices
Creators: name: Bordag, M.
name: Pirozhenko, I. G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider polarizable sheets, which recently received some attention, especially in context of the dispersion interaction of thin sheets like graphene. These sheets are modeled by a collection of delta function potentials and resemble "zero range potentials", known in quantum mechanics. We develop a theoretical description and apply the so-called "TGTG"-formula to calculate the interaction of two such lattices. Thereby we make use of the formulation of the scattering of waves off such sheets provided earlier. We consider all limiting cases, providing link to earlier results. Also, we discuss the relation to the pairwise summation method.
description: 12 pages, 4 figures
Additional file 2 of Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer
Creators: name: Wang, Chenxing
name: Aikemu, Batuer
name: Shao, Yanfei
name: Zhang, Sen
name: Yang, Guang
name: Hong, Hiju
name: Huang, Ling
name: Jia, Hongtao
name: Yang, Xiao
name: Zheng, Minhua
name: Sun, Jing
name: Li, Jianwen
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Supplementary fig. 2. The inhibition curve showing the differential sensitivity of CRC cell lines to treatment with rapamycin. CRC, colorectal cancer.
Implementations of two-photon four-qubit Toffoli and Fredkin gates assisted by nitrogen-vacancy centers
Creators: name: Wei, Hai-Rui
name: Zhu, Pei-Jin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is desirable to implement an efficient quantum information process demanding fewer quantum resources. We designed two compact quantum circuits for determinately implementing four-qubit Toffoli and Fredkin gates on single-photon systems in both the polarization and spatial degrees of freedom (DoFs) via diamond nitrogen-vacancy (NV) centers in resonators. The gates are heralded by the electron spins associated with the diamond NV centers. In contrast to the ones with one DoF, our implementations reduce the quantum resource and are robust against the decoherence. Evaluations of fidelities and efficiencies of our gates show that our schemes may be implemented with current technology.
description: 9 pages,5 figures
Experimental design and statistical tables from Priority effects are weakened by short, but not long, history of sympatric evolution
Creators: name: Zee, Peter C.
name: Fukami, Tadashi
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Schematic of experimental design and statistical tables
8-isopentenyl isoflavone derivatives from the whole herb of Sphaerophysa salsula
Creators: name: Jiao, Li-Jin
name: Wang, Wei-Dong
name: Yan-Duo Tao
name: Shao, Yun
name: Mei, Li-Juan
name: Zeng-Gen Liu
name: Qi-Lan Wang
name: Dang, Jun
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Phytochemical studies on the whole herb of Sphaerophysa salsula has resulted in the discovery of one new 8-isopentenyl isoflavone derivative, named sphaerosin s2 (3-(8-(2-hydroxypropan-2-yl)-3,4-dihydro-2H-furo[2,3-h]chromen-3-yl)-2,6-dimethoxyphenol) (1), along with four know 8-isopentenyl isoflavone derivatives (2–5). Compounds (2, 4 and 5) were isolated for the first time from this species. Their structures were elucidated on the basis of ESI-MS, UV, IR, 1D NMR and 2D NMR data.
Additional methods, figures, and table from Tropical bird species have less variable body sizes
Creators: name: Read, Quentin D.
name: Baiser, Benjamin
name: Grady, John M.
name: Zarnetske, Phoebe L.
name: Sydne Record
name: Belmaker, Jonathan
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60113 Synthetic Biology

description: Detailed information on compilation of covariates and potential dataset artifacts, additional phylogenetic analysis, scatterplots of relationships with covariates, figure illustrating model selection, and table of regression coefficients
Kassiopeia: A Modern, Extensible C++ Particle Tracking Package
Creators: name: Furse, Daniel
name: Groh, Stefan
name: Trost, Nikolaus
name: Babutzka, Martin
name: Barrett, John P.
name: Behrens, Jan
name: Buzinksy, Nicholas
name: Corona, Thomas
name: Enomoto, Sanshiro
name: Erhard, Moritz
name: Formaggio, Joseph A.
name: Glück, Ferenc
name: Harms, Fabian
name: Heizmann, Florian
name: Hilk, Daniel
name: Käfer, Wolfgang
name: Kleesiek, Marco
name: Leiber, Benjamin
name: Mertens, Susanne
name: Oblath, Noah S.
name: Renschler, Pascal
name: Schwarz, Johannes
name: Slocum, Penny L.
name: Wandkowsky, Nancy
name: Wierman, Kevin
name: Zacher, Michael
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The Kassiopeia particle tracking framework is an object-oriented software package using modern C++ techniques, written originally to meet the needs of the KATRIN collaboration. Kassiopeia features a new algorithmic paradigm for particle tracking simulations which targets experiments containing complex geometries and electromagnetic fields, with high priority put on calculation efficiency, customizability, extensibility, and ease of use for novice programmers. To solve Kassiopeia's target physics problem the software is capable of simulating particle trajectories governed by arbitrarily complex differential equations of motion, continuous physics processes that may in part be modeled as terms perturbing that equation of motion, stochastic processes that occur in flight such as bulk scattering and decay, and stochastic surface processes occuring at interfaces, including transmission and reflection effects. This entire set of computations takes place against the backdrop of a rich geometry package which serves a variety of roles, including initialization of electromagnetic field simulations and the support of state-dependent algorithm-swapping and behavioral changes as a particle's state evolves. Thanks to the very general approach taken by Kassiopeia it can be used by other experiments facing similar challenges when calculating particle trajectories in electromagnetic fields. It is publicly available at https://github.com/KATRIN-Experiment/Kassiopeia
Origin of meteoritic stardust unveiled by a revised proton-capture rate of $^{17}$O
Creators: name: Lugaro, M.
name: Karakas, A. I.
name: Bruno, C. G.
name: Aliotta, M.
name: Nittler, L. R.
name: Bemmerer, D.
name: Best, A.
name: Boeltzig, A.
name: Broggini, C.
name: Caciolli, A.
name: Cavanna, F.
name: Ciani, G. F.
name: Corvisiero, P.
name: Davinson, T.
name: Depalo, R.
name: Di Leva, A.
name: Elekes, Z.
name: Ferraro, F.
name: Formicola, A.
name: Fülöp, Zs.
name: Gervino, G.
name: Guglielmetti, A.
name: Gustavino, C.
name: Gyürky, Gy.
name: Imbriani, G.
name: Junker, M.
name: Menegazzo, R.
name: Mossa, V.
name: Pantaleo, F. R.
name: Piatti, D.
name: Prati, P.
name: Scott, D. A.
name: Straniero, O.
name: Strieder, F.
name: Szücs, T.
name: Takács, M. P.
name: Trezzi, D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Stardust grains recovered from meteorites provide high-precision snapshots of the isotopic composition of the stellar environment in which they formed. Attributing their origin to specific types of stars, however, often proves difficult. Intermediate-mass stars of 4-8 solar masses are expected to contribute a large fraction of meteoritic stardust. However, no grains have been found with characteristic isotopic compositions expected from such stars. This is a long-standing puzzle, which points to serious gaps in our understanding of the lifecycle of stars and dust in our Galaxy. Here we show that the increased proton-capture rate of $^{17}$O reported by a recent underground experiment leads to $^{17}$O/$^{16}$O isotopic ratios that match those observed in a population of stardust grains, for proton-burning temperatures of 60-80 million K. These temperatures are indeed achieved at the base of the convective envelope during the late evolution of intermediate-mass stars of 4-8 solar masses, which reveals them as the most likely site of origin of the grains. This result provides the first direct evidence that these stars contributed to the dust inventory from which the Solar System formed.
Quasinormal modes of black holes. The improved semianalytic approach
Creators: name: Matyjasek, Jerzy
name: Opala, Michał
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We have extended the semianalytic technique of Iyer and Will for computing the complex quasinormal frequencies of black holes, $ω,$ by constructing the Padé approximants of the (formal) series for $ω^{2}$. It is shown that for the (so far best documented) quasinormal frequencies of the Schwarzschild and Reissner-Nordström black holes the Padé transforms $P_{6}^{6}$ and $P_{7}^{6}$ are, within the domain of applicability, always in excellent agreement with the numerical results. We argue that the method may serve as the black box with the "potential" $Q(x)$ as an input and the accurate quasinormal modes as the output. The generalizations and modifications of the method are briefly discussed as well as the preliminary results for other classes of the black holes.
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance
Creators: name: Liping, Yang
name: Jian, He
name: Zhenchao, Tao
name: Yan, Zhou
name: Jing, Yang
name: Yangyang, Zhang
name: Jing, Gao
name: Liting, Qian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Cancer poses a serious threat to human health and is the most common cause of human death. Polymer-based nanomedicines are presently used to enhance the treatment effectiveness and decrease the systemic toxicity of chemotherapeutic agents. However, the disadvantage of currently polymeric carriers is without therapy procedure. Herein, for the first time, glutathione (GSH)-responsive polymer (PRES) with anti-cancer effect was synthesized following the condensation–polymerization method using resveratrol (RES) and 3,3′-dithiodipropionic acid. PRES can not only suppress the tumor cells growth but can also self-assemble into nanoparticles (∼93 nm) for delivering antitumor drugs, such as paclitaxel (PTX@PRES NPs). The system could achieve high drug loading (∼7%) and overcome multidrug resistance (MDR). The results from the in vitro studies revealed that the NPs formed of PRES were stable in the systemic circulation, while could be efficiently degraded in tumor cells high GSH environment. Results from cytotoxicity tests confirmed that PTX@PRES NPs could effectively suppress the growth of cancer cells (A549) and drug-resistant cells (A549/PTX). The NPs could also be used to significantly increase the therapeutic efficacy of the drugs in A549/PTX tumor-bearing mice. In vivo investigations also demonstrated that the PRES-based NPs exhibited tumor inhibition effects. In summary, we report that the GSH-responsive polymer synthesized by us exhibited multiple interesting functions and could be used for effective drug delivery. The polymer exhibited good therapeutic effects and could be used to overcome MDR. Thus, the synthesized system can be used to develop a new strategy for treating cancer.
DIDAKTIK DRAMA USULI YORDAMIDA PEDAGOGIK TA'LIMDA KASBIY KOMPETENSIYALARNI SHAKLLANTIRISH IMKONIYATLARI
Creators: name: Xolbayeva, Dildora
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada didaktik drama usulining pedagogik ta’limda kasbiy kompetensiyalarni shakllantirishdagi o‘rni va ahamiyati tahlil etilgan. Tadqiqot natijalariga ko‘ra, drama usuli orqali talabalar nazariy bilimlarni real hayotiy vaziyatlarda qo‘llash, kommunikativ, refleksiv, ijodiy va ijtimoiy-emosional kompetensiyalarni rivojlantirish imkoniyatiga ega bo‘lishlari aniqlangan. Maqolada drama usulining an’anaviy o‘qitish metodlaridan afzalliklari, drama mashg‘ulotlari shakllari va amaliy tajriba natijalari bayon qilingan. Shuningdek, pedagogik ta’lim dasturlariga drama faoliyatini integratsiyalash va baholash mezonlarini ishlab chiqish bo‘yicha tavsiyalar ilgari surilgan.
Supplementary Methods from Social manipulation of sperm competition intensity reduces seminal fluid gene expression
Creators: name: Sloan, Nadia S.
name: Lovegrove, Maxine
name: Simmons, Leigh W.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Methods for gene expression assays
title: ADCO, Cart. 186 (11 H 71), f. 0089r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0089r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Hearts of twin Cotorsion pairs on extriangulated categories
Creators: name: Liu, Yu
name: Nakaoka, Hiroyuki
Publisher: name: arXiv
Year: 2017
Subjects: subject: Category Theory (math.CT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In this article, we study the heart of a cotorsion pairs on an exact category and a triangulated category in a unified meathod, by means of the notion of an extriangulated category. We prove that the heart is abelian, and construct a cohomological functor to the heart. If the extriangulated category has enough projectives, this functor gives an equivalence between the heart and the category of coherent functors over the coheart modulo projectives. We also show how an n-cluster tilting subcategory of an extriangulated category gives rise to a family of cotorsion pairs with equivalent hearts.
description: 36 pages
Mathematical supplement from Quantitative approaches to energy and glucose homeostasis: machine learning and modelling for precision understanding and prediction
Creators: name: McGrath, Thomas
name: Murphy, Kevin G.
name: Jones, Nick S.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Mathematical details for all models referenced in the main text
Green synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma
Creators: name: Yang, Zhongwei
name: Liu, Zijing
name: Zhu, Junmo
name: Xu, Jie
name: Pu, Youwei
name: Bao, Yixi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Physical Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Gold nanoparticles (AuNPs) were successfully fabricated by Pholiota adiposa polysaccharide (PAP-1a) without employing any other chemicals. The physical and chemical properties of PAP-AuNPs were determined using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDXR), Fourier-transform infrared spectroscopy (FT-IR), and atomic force microscopy (AFM). In an attempt to analyze the immune regulation, antitumor effect, and biological safety, the production of NO and TNF-α, IL-12p70, and IL-1β from RAW264.7 as well as the proliferation of RAW264.7 were detected in vitro. Flow cytometry was conducted to determine the ratio of the CD4+/CD8+ cell in peripheral blood and immunohistochemical analysis involving hematoxylin and eosin (H&E) and proliferating cell nuclear antigen (PCNA) staining were conducted in vivo. The results of this study showed that PAP-AuNPs had a significantly improved immune regulation and anti-tumor effect in comparison to PAP-1a alone. PAP-AuNPs showed no toxicity both in vivo and in vitro. This study demonstrates a useful application of PAP-AuNPs as a novel nanomedicine for hepatic carcinoma.
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization
Creators: name: Bi, Qiu-Chen
name: Tang, Jian-Jun
name: Zhao, Jun
name: Lv, Yang-Feng
name: Deng, Zhi-Qiang
name: Chen, Hong
name: Xu, Yu-Hua
name: Xie, Chuan-Sheng
name: Liang, Qing-Rong
name: Luo, Rong-Guang
name: Tang, Qun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Developmental Biology
Cancer

description: Arsenic trioxide (As2O3, ATO) has limited therapeutic benefit to treat solid tumors, whether used alone or in combination. Nanoscale drug delivery vehicles have great potential to overcome the limitation of the utility of ATO by rapid renal clearance and dose-limiting toxicity. Polymeric materials ranging from gelatin foam to synthetic polymers such as poly(vinyl alcohol) were developed for vascular embolic or chemoembolic applications. Recently, we have introduced sevelamer, an oral phosphate binder, as a new polymeric embolic for vascular interventional therapy. In this paper, sevelamer arsenite nanoparticle with a polygonal shape and a size of 50–300 nm, synthesized by anionic exchange from sevelamer chloride, was developed as a Pi-responsive bifunctional drug carrier and embolic agent for chemoembolization therapy. At the same arsenic dosage, sevelamer arsenite-induced severer tumor necrosis than ATO on the VX2 cancer model. In vitro tests evidenced that Pi deprivation by sevelamer could enhance ATO’s anticancer effect. The results showed that ATO in Pi starvation reduced cell viability, induced more apoptosis, and diminished the mitochondrial membrane potential (Δψm) of cells since Pi starvation helps ATO to further down-regulate Bcl-2 expression, up-regulate Bax expression, enhance the activation of caspase-3 and increase the release of cytochrome c, and the production of excessive reactive oxygen species (ROS). Sevelamer arsenite not only plays a Pi-activated nano-drug delivery system but also integrated anticancer drug with embolic for interventional therapy. Therefore, our results presented a new administration route of ATO as well as an alternative chemoembolization therapy.
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling
Creators: name: Fereig, Salma
name: El-Zaafarany, Ghada M.
name: Arafa, Mona
name: Abdel-Mottaleb, Mona M. A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Gold nanoparticles are a promising drug delivery system for treatment of inflammatory skin conditions, including psoriasis, due to their small size and anti-inflammatory properties. The aim of this study was to conjugate gold nanoparticles with anti-psoriatic formulations that previously showed successful results in the treatment of psoriasis (tacrolimus-loaded chitosan nanoparticles and lecithin–chitosan nanoparticles) by virtue of their surface charges, then examine whether the hybridization with gold nanoparticles would enhance the anti-psoriatic efficacy in vivo. Successful formation of gold nanoparticles was examined by elemental mapping and selected area electron diffraction (SAED). Hybrid conjugates were examined in terms of particle size and zeta potential by dynamic light scattering (DLS). Morphological features were captured by transmission electron microscope (TEM) and X-ray diffraction (XRD) analysis was conducted, as well. All characterization was conducted for the conjugated nanoparticles and compared with their bare counterparts. The in vivo results on imiquimod (IMQ)-induced mouse model showed promising anti-psoriatic effects upon application of gold conjugated tacrolimus-loaded lecithin–chitosan hybrid nanoparticles with a significant difference from the bare hybrid nanoparticles in some of the inflammatory markers. The anti-inflammatory effect of the gold conjugate was also evident by a lower spleen to body weight ratio and a better histopathological skin condition compared to other tested formulations.
Stellar yields and abundances: new directions from planetary nebulae
Creators: name: Lugaro, Maria
name: Karakas, Amanda I.
name: Pignatari, Marco
name: Doherty, Carolyn L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Planetary nebulae retain the signature of the nucleosynthesis and mixing events that occurred during the previous AGB phase. Observational signatures complement observations of AGB and post-AGB stars and their binary companions. The abundances of the elements heavier than iron such as Kr and Xe in planetary nebulae can be used to complement abundances of Sr/Y/Zr and Ba/La/Ce in AGB stars, respectively, to determine the operation of the slow neutron-capture process (the s process) in AGB stars. Additionally, observations of the Rb abundance in Type I planetary nebulae may allow us to infer the initial mass of the central star. Several noble gas components present in meteoritic stardust silicon carbide (SiC) grains are associated with implantation into the dust grains in the high-energy environment connected to the fast winds from the central stars during the planetary nebulae phase.
description: Proceedings IAU Symposium No. 323 "Planetary nebulae: Multi-wavelength probes of stellar and galactic evolution", 2016 (X. Liu, L. Stanghellini & A. I. Karakas, eds.)
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity
Creators: name: Li, Mengmeng
name: Zhu, Ya
name: Yang, Chao
name: Yang, Mi
name: Ran, Haitao
name: Zhu, Yefeng
name: Zhang, Wei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: We fabricated an ultrasound activated ‘nanobomb’ as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy and priming cancer immunotherapy. This ‘nanobomb’ was rationally designed via the encapsulation of indocyanine green (ICG) and perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with cRGD peptide could actively targeted ID8 and TC-1 cells and elicits ROS-mediated apoptosis after triggered by low-intensity focused ultrasound (LIFU). Moreover, the phase change of PFP (from droplets to microbubbles) under LIFU irradiation can produce a large number of microbubbles, which act as intra-tumoral bomber and can detonate explode tumor cells by acoustic cavitation effect. Instant necrosis of tumor cells further induces the release of biologically active damage-associated molecular patterns (DAMPs) to facilitate antitumor immunity. More important, the ‘nanobomb’ in combination with anti-PD-1checkpoint blockade therapy can significantly improve the antitumor efficacy in a subcutaneous model. In addition, the liposomes may also be used as an imaging probe for ultrasound (US) imaging after being irradiated with LIFU. In summary, the US imaging-guided, LIFU activated ROS production and explosion ‘nanobomb’ might significantly improve the antitumor efficacy and overcome drug resistance through combination of SDT and immunotherapy, we believe that this is a promising approach for targeted therapy of solid tumor including ovarian cancer. This ‘nanobomb’ was rationally designed via the encapsulation of ICG and PFP into cRGD peptide-functionalized nano-liposome. The US imaging-guided, LIFU activated ROS production and explosion ‘nanobomb’ can significantly improve anti-cancer efficacy and overcome drug resistance through combination of SDT and immunotherapy.
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments
Creators: name: Zakaria, Mohamed Y.
name: Zaki, Islam
name: Alhomrani, Majid
name: Alamri, Abdulhakeem S.
name: Abdulaziz, Osama
name: Abourehab, Mohammed A.S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Resveratrol (RSV) is a phytoceutical polyphenolic compound exhibiting a well evidenced wide range of therapeutic activities. Unfortunately, its diminished aqueous solubility and extensive metabolism in gastro intestinal tract (GIT) and liver prohibit its biological activity and systemic availability. Herein the conducted study PEG stabilized emulsomes (PEMLs) were customized to enclose RSV aiming to boost its biological availability and antiviral activity. PEGylating the vesicles not only grant the promoted steric stability of the system but also being beneficial in exaggerating the intestinal permeability and extending the period of circulation of the drug, hence its targeted clinical use. The Investigation of the influence of predetermined variables on the physical characterization of formulae (entrapment efficiency EE%, particle size PS and zeta potential ZP) was implemented utilizing Design Expert® software. (F4) with desirability value (0.772), picked to be the optimal formula, which is fabricated utilizing 35 mg compritol as the lipidic core and 60 mg 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-Mpeg-2000). The dominance of the F4 relative to RSV dispersion was affirmed by the data acquired from ex-vivo and pharmacokinetic studies. In addition, F4 exhibited significant lower EC50 value (0.0127 µg/mL) relative to that of RSV dispersion(0.338 µg/mL) by around 26 times denoting the capability of the formulation to boost the antiviral activity. To a great extent, F4 was able to significantly suppress the inflammatory response and oxidative stress resulted from MERS-CoV infection on comparison with RSV dispersion. Finally, the potentiality of PEMLs as nano-panel with boosted both antiviral and oral bioavailability for RSV could be deduced based on the outcomes mentioned herein.
Supplementary Material for: Screening for Brain Involvement in Infants with Multifocal Cutaneous Infantile Hemangiomas
Creators: name: Friedland, R.
name: Ben Amitai, D.
name: Zvulunov, A.
Publisher: name: Karger Publishers
Year: 2018
Subjects: Medicine

description: Background: Multifocal (≥5) infantile hemangiomas (IHs) are known as a risk factor for extracutaneous involvement. Liver is the most commonly involved organ, but involvement of other systems has also been reported. This study aims to describe the characteristic findings in a group of infants with multiple cutaneous hemangiomas, with emphasis on intracranial involvement. Methods: A retrospective case series study was carried out in a pediatric dermatology unit of a tertiary pediatric medical center. Patients diagnosed with multiple cutaneous IHs from 2006 to 2015 were identified by a computerized search. Clinical data were retrieved from the medical charts. Results: A total of 60 infants (37 females and 23 males) were identified for analysis. Forty-four brain ultrasounds were recorded and reported as normal. One patient out of the 44 was later diagnosed with a small asymptomatic hemangioma seen on a brain MRI/MRA done for another indication. Conclusion: Brain hemangiomas may present as an asymptomatic incidental finding in infants presenting with multifocal cutaneous and liver IHs. The single case reported in our study emphasizes the low prevalence and the benign course expected. Therefore, routine ultrasound screening for brain involvement is probably unnecessary for this population.
Project Periodic Report n°1 - D1.2 INVADE H2020
Creators: name: Hirdes, Dieter
Publisher: name: Zenodo
Year: 2018

description: INVADE project aims to deliver a Cloud-based flexibility management system integrated with EVs and batteries empowering energy storage at mobile, distributed and centralised levels to increase the share of renewables in the smart grid. The overall objective is to be reached by the achievement of the following sub-objectives (SOs) and the different achievements obtained in the different work packages (WPs). The work carried out during the first reporting period towards the achievement of each objective is explained in this document.
A portable magnetic field of > 3 T generated by the flux jump assisted, pulsed field magnetisation of bulk superconductors
Creators: name: Zhou, Difan
name: Ainslie, Mark D.
name: Shi, Yunhua
name: Dennis, Anthony R.
name: Huang, Kaiyuan
name: Hull, John R.
name: Cardwell, David A.
name: Durrell, John H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A trapped magnetic field of greater than 3 T has been achieved in a single grain GdBa2Cu3O7-δ (GdBaCuO) bulk superconductor of diameter 30 mm by employing pulsed field magnetisation (PFM). The magnet system is portable and operates at temperatures between 50 K and 60 K. Flux jump behaviour was observed consistently during magnetisation when the applied pulsed field, Ba, exceeded a critical value (e.g. 3.78 T at 60 K). A sharp dBa/dt is essential to this phenomenon. This flux jump behaviour enables the magnetic flux to penetrate fully to the centre of the bulk superconductor, resulting in full magnetization of the sample without requiring an applied field as large as that predicted by the Bean model. We show that this flux jump behaviour can occur over a wide range of fields and temperatures, and that it can be exploited in a practical quasi-permanent magnet system.
description: 8 pages, 4 figures. Accepted for publication in APL