cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins
Creators: name: Chuva de Sousa Lopes, Susana M.
name: ten Dijke, Peter
name: Monteiro, Rui M.
name: Korchynskyi, Olexander
name: Mummery, Christine L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Signaling by bone morphogenetic proteins is essential for a wide variety of developmental processes. Receptor-regulated Smad proteins, Smads 1 and 5, are intracellular mediators of bone morphogenetic protein signaling. Together with Smad4, these proteins translocate to the nucleus and modulate transcription by binding to specific sequences on the promoters of target genes. We sought to map transcriptional Smad1/5 activity in development by generating embryonic stem cell lines carrying a Smad1/5-specific response element derived from the
Download Pdf The Art of Final Fantasy XVI by Square Enix
Creators: name: Gertz
Publisher: name: Zenodo
Year: 2024

description: The Art of Final Fantasy XVI by Square Enix

 

 

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The Art of Final Fantasy XVI

Square Enix

Page: 320

Format: pdf, ePub, mobi, fb2

ISBN: 9781646092369

Publisher: Square Enix

 

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The official art book for the hugely anticipated video game Final Fantasy XVI, this collector’s quality, hardcover volume offers a wealth of full-color key art, concept sketches, and more. In these lavishly illustrated pages, see how the world of Final Fantasy XVI was brought to life through hundreds of pieces of concept art and illustrations. Featuring the phenomenal work of the Final Fantasy XVI development artists, this volume is a superb visual compendium of Valisthea, from its Dominants and Eikons to its warring nations and rulers to its creatures and devices. At over 300 pages, this hardcover volume is printed on archival-quality paper stock and bound with a full-color casewrap and foil-stamped jacket.
The dynamic kinetochore-microtubule interface
Creators: name: Salmon, E. D.
name: Maiato, Helder
name: Earnshaw, William C.
name: DeLuca, Jennifer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably fluid, with the microtubules growing and shrinking at their point of attachment to the kinetochore. Furthermore, the kinetochore itself is highly dynamic, its makeup changing as cells enter mitosis and as it encounters microtubules. Active kinetochores have yet to be isolated or reconstituted, and so the structure remains enigmatic. Nonetheless, recent advances in genetic, bioinformatic and imaging technology mean we are now beginning to understand how kinetochores assemble, bind to microtubules and release them when the connections made are inappropriate, and also how they influence microtubule behaviour. Recent work has begun to elucidate a pathway of kinetochore assembly in animal cells; the work has revealed that many kinetochore components are highly dynamic and that some cycle between kinetochores and spindle poles along microtubules. Further studies of the kinetochore-microtubule interface are illuminating: (1) the role of the Ndc80 complex and components of the Ran-GTPase system in microtubule attachment, force generation and microtubule-dependent inactivation of kinetochore spindle checkpoint activity; (2) the role of chromosomal passenger proteins in the correction of kinetochore attachment errors; and (3) the function of microtubule plus-end tracking proteins, motor depolymerases and other proteins in kinetochore movement on microtubules and movement coupled to microtubule poleward flux.
Read [pdf]> I Am Zuko (Avatar: The Last Airbender) by Mei Nakamura, Bao Luu
Creators: name: Volk
Publisher: name: Zenodo
Year: 2024

description: I Am Zuko (Avatar: The Last Airbender) by Mei Nakamura, Bao Luu

 

 

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I Am Zuko (Avatar: The Last Airbender)

Mei Nakamura, Bao Luu

Page: 24

Format: pdf, ePub, mobi, fb2

ISBN: 9780593707692

Publisher: Random House Children's Books

 

Download ebooks free deutsch I Am Zuko (Avatar: The Last Airbender) ePub DJVU by Mei Nakamura, Bao Luu in English 9780593707692

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A requirement for membrane cholesterol in the  -arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors
Creators: name: Severin, Jamie E.
name: Jones, Kymry T.
name: Urs, Nikhil M.
name: Trejo, Jo Ann
name: Salo, Paul D.
name: Radhakrishna, Harish
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA
Descargar POESIA COMPLETA ZBIGNIEW HERBERT Gratis - EPUB, PDF y MOBI
Creators: name: Smith
Publisher: name: Zenodo
Year: 2024

description: POESIA COMPLETA de ZBIGNIEW HERBERT

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POESIA COMPLETA

ZBIGNIEW HERBERT

Número de páginas: 656

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788426421302

Editorial: LUMEN

Año de edición: 2019

 

 

 

 

 

Descargar gratis nuevos ebooks ipad POESIA COMPLETA

 

Overview

El polaco Zbigniew Herbert pertenece, junto a T. S. Eliot, W. H. Auden, Joseph Brodsky o su compatriota Czeslaw Milosz, a la restringida familia de los grandes poetas del siglo XX. Por primera vez en castellano, este volumen recoge, en la espléndida versión de Xaverio Ballester, su poesía completa.Los poemas de Herbert, compuestos en un estilo coloquial, diáfano y complejo a un tiempo, transitan por un espacio en el que se entreveran el mito, la historia, la política, el arte y la intimidad. Leer a Herbert constituye una experiencia intensa e insoslayable."El idioma de Herbert está forjado en la necesidad. Es el gran ironista de la historia. Cuando uno lee sus poemas, siente la mente marcada por su lucidez de hielo. Es un poeta para nuestro tiempo."Joseph Brodsky
Additional file 1 of Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1
Creators: name: Toft-Bertelsen, Trine L.
name: Barbuskaite, Dagne
name: Heerfordt, Eva Kjer
name: Lolansen, Sara Diana
name: Andreassen, Søren Norge
name: Rostgaard, Nina
name: Olsen, Markus Harboe
name: Norager, Nicolas H.
name: Capion, Tenna
name: Rath, Martin Fredensborg
name: Juhler, Marianne
name: MacAulay, Nanna
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 1. LPA quantification, choroid plexus viability, and 3D imaging of the rat ventricular system.
From ripples to spikes: a hydro-dynamical physical mechanism to interpret femtosecond laser induced self-assembled structures
Creators: name: Tsibidis, George D.
name: Fotakis, Costas
name: Stratakis, Emmanuel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Materials irradiated with multiple femtosecond laser pulses in sub-ablation conditions are observed to develop various types of self-assembled morphologies that range from nano-ripples to periodic micro-grooves and quasi-periodic micro-spikes. Here, we present a physical scenario that couples electrodynamics, describing surface plasmon excitation, with hydrodynamics, describing Marangoni convection, to elucidate this important sub-ablation regime of light matter interaction in which matter is being modified, however, the underlying process is not yet fully understood. The proposed physical mechanism could be generally applicable to practically any conductive material structured by ultrashort laser pulses, therefore it can be useful for the interpretation of further critical aspects of light matter interaction.
description: arXiv admin note: substantial text overlap with arXiv:1109.2568
Palmitoylation of claudins is required for efficient tight-junction localization
Creators: name: Carson, John L.
name: Anderson, James M.
name: Gambling, Todd M.
name: Van Itallie, Christina M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Palmitoylation of integral membrane proteins can affect intracellular trafficking, protein-protein interactions and protein stability. The goal of the present study was to determine whether claudins, transmembrane-barrier-forming proteins of the tight junction, are palmitoylated and whether this modification has functional implications for the tight-junction barrier. Claudin-14, like other members of the claudin family, contains membrane-proximal cysteines following both the second and the fourth transmembrane domains, which we speculated could be modified by
Open Data? Zum Umgang mit Forschungsdaten in den ethnologischen Fächern
Creators: name: Imeri, Sabine
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: Forschungsdaten
subject: Forschungsdatenmanagement
subject: Ethnologie
subject: Sozialanthropologie
subject: Kulturanthropologie
subject: Open Data
subject: 301 Soziologie, Anthropologie
subject: 020 Bibliotheks- und Informationswissenschaften

description: In den ethnologischen Fächern sind Fragen von Forschungsdatenmanagement bisher kaum diskutiert. Der Beitrag berichtet vor dem Hintergrund der Spezifik ethnografischer Forschung und auf der Grundlage einer Online-Umfrage wie EthnologInnen Chancen und Probleme von Langzeitarchivierung und Data-Sharing einschätzen und welche Bedingungen für die Überführung ethnografischer Materialien in digitale Langzeitarchive sich daraus ergeben. Wie offen können Forschungsdaten überhaupt gemacht werden?
(2828) Margerie [Beswick] Myers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Spindle microtubules in flux
Creators: name: Rogers, Gregory C.
name: Sharp, David J.
name: Rogers, Stephen L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Accurate and timely chromosome segregation is a task performed within meiotic and mitotic cells by a specialized force-generating structure - the spindle. This micromachine is constructed from numerous proteins, most notably the filamentous microtubules that form a structural framework for the spindle and also transmit forces through it. Poleward flux is an evolutionarily conserved mechanism used by spindle microtubules both to move chromosomes and to regulate spindle length. Recent studies have identified a microtubule-depolymerizing kinesin as a key force-generating component required for flux. On the basis of these findings, we propose a new model for flux powered by a microtubule-disassembly mechanism positioned at the spindle pole. In addition, we use the flux model to explain the results of spindle manipulation experiments to illustrate the importance of flux for proper chromosome positioning.
[Kindle] MI NOMBRE ES ASHER LEV descargar gratis
Creators: name: Papadopoulos
Publisher: name: Zenodo
Year: 2024

description: MI NOMBRE ES ASHER LEV de CHAIM POTOK

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MI NOMBRE ES ASHER LEV

CHAIM POTOK

Número de páginas: 320

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788474908848

Editorial: ENCUENTRO

Año de edición: 2008

 

 

 

 

 

Descargar libros de texto a la tableta. MI NOMBRE ES ASHER LEV de CHAIM POTOK

 

Overview

Asher Lev es un niño judío observante que pertenece a una familia profundamente religiosa. Asher Lev también tiene un don: es un genio que no puede dejar de pintar el mundo que ve y siente. Pero en este don está la semilla del conflicto con lo que más quiere: su familia y su comunidad. En esta novela conmovedora y visionaria, Chaim Potok realiza un agudo retrato del artista y de su mundo. Todo un clásico moderno.
[ePub] LOS AMOS DEL AIRE descargar gratis
Creators: name: Paugh
Publisher: name: Zenodo
Year: 2024

description: LOS AMOS DEL AIRE de DONALD L. MILLER

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LOS AMOS DEL AIRE

DONALD L. MILLER

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788412744323

Editorial: DESPERTA FERRO EDICIONES

Año de edición: 2024

 

 

 

 

 

Ibooks epub descargas LOS AMOS DEL AIRE en español 9788412744323

 

Overview

Tras Hermanos de sangre y The Pacific, Los amos del aire es el libro que ha inspirado la nueva serie de Steven Spielberg y Tom Hanks para Apple TV. Los amos del aire es la historia personal de los bombarderos aliados que en la Segunda Guerra Mundial golpearon con su carga letal el mismísimo corazón del Tercer Reich. Combinando el poder del rigor histórico con la fuerza narrativa propia de la mejor ficción, su aclamado autor, Donald Miller, transporta al lector en un viaje trepidante a través de los cielos teñidos de fuego sobre Berlín, Hannover y Dresde, una guerra sin cuartel con devastadoras consecuencias tanto para la maquinaria de guerra nazi como para el pueblo alemán librada a más de 7000 metros de altitud, unas cotas a las que jamás se había combatido anteriormente y que llevaron a extremos inconcebibles la resistencia física y psicológica de las tripulaciones aliadas. El combate aéreo era mortal pero intermitente: periodos de inactividad y ansiedad eran seguidos por breves descargas de fuego y terror. La campaña de bombardeos angloamericana contra la Alemania nazi fue la operación militar más larga de la Segunda Guerra Mundial, una guerra dentro de otra guerra. Hasta que los soldados aliados entraron en Alemania en los últimos meses de la guerra, fue la única batalla librada dentro de territorio germano. Pero más allá de los aspectos militares, Los amos del aire es un relato tremendamente humano, de la vida en la Inglaterra del momento y en los campos de prisioneros alemanes, donde decenas de miles de aviadores pasaron parte de la guerra, y de las espeluznantes marchas del hambre que los aviadores capturados se vieron obligados a realizar a través del país que sus bombas destruyeron. Elaborado a partir de entrevistas recientes, historias orales y archivos estadounidenses, británicos, alemanes y de otros países, Los amos del aire es un relato autorizado y profundamente conmovedor de la primera y única guerra de bombarderos de la historia.
(2830) May Laycock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Beyond vancomycin: recent advances in the modification, reengineering, production, and discovery of improved glycopeptide antibiotics to tackle multi-drug resistant bacteria
Creators: name: Hansen, Mathias
name: Stegmann, Evi
name: Cryle, Max
Publisher: name: Monash University
Year: 2023
Subjects: Proteins and peptides
Natural products and bioactive compounds

description: Glycopeptide antibiotics (GPA), which include vancomycin and teicoplanin, are important lastresort antibiotics used to treat multidrug-resistant Gram-positive bacterial infections. Whilst second generation GPAs – generated through chemical modification of natural GPAs – have proven successful, the emergence of GPA resistance has underlined the need to develop new members of this compound class. Significant recent advances have been made in GPA research, including gaining an in-depth understanding of their biosynthesis, improving titre in production strains, developing new derivatives via novel chemical modifications, and identifying a new mode of action for structurally diverse Type V GPAs. Taken together, these advances demonstrate significant untapped potential for the further development of GPAs to tackle the growing threat of multidrug resistant bacteria.
Imaging an aligned polyatomic molecule with laser-induced electron diffraction
Creators: name: Pullen, Michael
name: Wolter, Benjamin
name: Le, Anh-Thu
name: Baudisch, Matthias
name: Hemmer, Michaël
name: Senftleben, Arne
name: Schröter, Claus Dieter
name: Ullrich, Joachim
name: Moshammer, Robert
name: Lin, Chii-Dong
name: Biegert, Jens
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Laser-induced electron diffraction is an evolving tabletop method, which aims to image ultrafast structural changes in gas-phase polyatomic molecules with sub-Ångström spatial and femtosecond temporal resolution. Here, we provide the general foundation for the retrieval of multiple bond lengths from a polyatomic molecule by simultaneously measuring the C-C and C-H bond lengths in aligned acetylene. Our approach takes the method beyond the hitherto achieved imaging of simple diatomic molecules and is based upon the combination of a 160 kHz mid-IR few-cycle laser source with full three-dimensional electron-ion coincidence detection. Our technique provides an accessible and robust route towards imaging ultrafast processes in complex gas phase molecules with atto- to femto-second temporal resolution.
description: 16 pages, 4 figures
The Ras superfamily at a glance
Creators: name: Rossman, Kent L.
name: Der, Channing J.
name: Wennerberg, Krister
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members (Table S1 in [supplementary material][1]), with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, S. pombe, Dictyostelium and plants ([Colicelli, 2004][2]). The Ras
[PDF EPUB] Download Taken by Fate by Shannon Mayer Full Book
Creators: name: Gragg
Publisher: name: Zenodo
Year: 2024

description: Taken by Fate by Shannon Mayer

 

 

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Taken by Fate

Shannon Mayer

Page: 320

Format: pdf, ePub, mobi, fb2

ISBN: 9781987933833

Publisher: Hijinks Ink Publishing

 

Free ebook downloads for tablet Taken by Fate by Shannon Mayer

Plucked out of the Collector's Pens, auctioned off to a vampire contingent, and sent across the ocean to the Alpha Territories was not exactly how I planned to spend my week. Actually, scratch that. I had planned the first bit. But I was supposed to be sold to the werewolves so I could save my friend from a fate worse than death. Instead, the bloodsuckers have me and so far? It's not going great. I've been shoved into a corset and made to look like an extra on the cast of Bridgerton, all to take part in the Harvest Games--think The Bachelor set in the 1800's, but the men are all vampires, and then add a decidedly terrifying Squid Games element to the mix. No problem. My goal-besides keeping the number of holes in my body to the current norm-is more than surviving. It is escaping the inescapable, finding my way to the werewolf territory, and getting Jordan back. Cue the political strife. Armed with nothing more than a super sharp hairpin, my questionable charm, and an irrational amount of optimism, plans to get both me and my bestie out alive are in full swing. Until the General of the Vampire Army and his molten eyes light me on fire and leave me wondering if escape is what I want after all. Maybe one extra set of holes wouldn't be the worst thing ever...

Challenges, Conflicts, and Contests - Fate SRDOther times you'll face extended engagements that take many rolls to resolve. For those cases, we offer three resolution tools: challenges, contests, Fate - Definition, Meaning & Synonyms - Vocabulary.comThe word fate traces back to the Latin word fatum, meaning “that which has been spoken,” and something that's your fate is a done deal, not open to revision Things Fall Apart Fate and Free Will | ShmoopHis life is shameful and his death offers no redemption or even an easy way out. He dies in shame. The year that Okonkwo took eight hundred seed-yams from Simple Twist of Fate - Wikipedia"Simple Twist of Fate", a song by American singer-songwriter Bob Dylan, was recorded on Dylanesque (2007); by Jeff Tweedy (with altered lyrics taken from a live Migrants Flown to Martha's Vineyard Say They Were MisledAnd it demonstrated once again how easily the fate of immigrants can be 20, the migrants taken to Martha's Vineyard filed a lawsuit Skate Fate - InstagramFollow. Skate Fate. Founded in 1981, Skate Fate is a zine about skateboarding. Buy Issue #77 and The Best of Skate Fate book at Photo taken on October.Twist of Fate (Olivia Newton-John song) - Wikipedia"Jolene" (UK) · "Take a Chance" (with John Travolta) (US).Conflicts - Fate SRDYou know the conflict is over when everyone on one of the sides has conceded or been taken out. Fate Core.
Metallic State of Low Mobility Silicon at High Carrier density induced by an Ionic Liquid
Creators: name: Nelson, JJ
name: Goldman, A. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: High mobility and dilute two-dimensional electron systems exhibit metallic behavior down to the lowest experimental temperatures. In studies of ionic liquid gated insulating silicon, we have observed transitions to a metallic state in low mobility samples at much higher areal carrier densities than found for samples of high mobility. We have also observed a mobility peak in metallic samples as the carrier density was increased beyond $10^{13} \text{cm}^{-2}$.
{epub descargar} LA FILOSOFÍA DE BITCOIN
Creators: name: Jones
Publisher: name: Zenodo
Year: 2024

description: LA FILOSOFÍA DE BITCOIN de ÁLVARO D. MARÍA

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Ficha técnica

LA FILOSOFÍA DE BITCOIN

ÁLVARO D. MARÍA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788423436705

Editorial: DEUSTO

Año de edición: 2024

 

 

 

 

 

Ebook para ipod nano descargar LA FILOSOFÍA DE BITCOIN (Spanish Edition)

 

Overview

Redefinir el concepto de propiedad privada creando un espacio donde los Estados carecen de soberaníaEl Estado y la moneda están sumidos en una profunda crisis que nos obliga a revisar nuestros sistemas de creencias políticas y económicas. Fundamentalmente son dos: que el dinero debe tener el respaldo de una autoridad y que el concepto Estado puede aplicarse a cualquier sociedad política. El filósofo Álvaro D. María sostiene que sí es posible pensar en formas políticas posestatales. Bitcoin redefine el derecho de propiedad privada haciéndolo absoluto y creando un espacio donde los Estados carecen de soberanía. A su juicio, este último está agotado como forma política y contra él sólo cabe la acción «criptocrática», aquella en la que el poder no sabe quién organiza los ataques. El ciberespacio es el lugar óptimo para esa lucha y Bitcoin, su mejor arma. Este libro explora por qué Bitcoin es una innovación sólo comparable a la de la pólvora, la imprenta o Internet. Mediante una aproximación filosófica ?donde el autor reflexiona sobre las relaciones entre dinero y moneda, y qué innovaciones presenta Bitcoin en el campo económico, jurídico y político? es posible advertir el alcance histórico que tendrá esta divisa digital en nuestras vidas.
Table S6 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Results and primers used to confirm viral presence in the H. catenoides genome
{epub download} The Invisible Life of Addie LaRue by V. E. Schwab
Creators: name: Sutton
Publisher: name: Zenodo
Year: 2024

description: The Invisible Life of Addie LaRue by V. E. Schwab

 

 

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The Invisible Life of Addie LaRue

V. E. Schwab

Page: 448

Format: pdf, ePub, mobi, fb2

ISBN: 9781250793997

Publisher: Tom Doherty Associates

 

Free pdf ebooks for download The Invisible Life of Addie LaRue by V. E. Schwab

The Invisible Life of Addie LaRue by V. E. Schwab • Epilogue In the vein of The Time Traveler's Wife and Life After Life, The Invisible Life of Addie LaRue is New York Times bestselling author V. E. Schwab's genre-defying  The Invisible Life of Addie LaRue (Hardcover) | Copper Dog “Epic, beautifully written, heartwarming, and heartbreaking, The Invisible Life of Addie LaRue is a contemplation on life, death, what it means to  The Invisible Life of Addie LaRue by V.E. Schwab The Invisible Life of Addie LaRue | Click Here For the Autographed Copy! A Life No One Will Remember. A Story You Will Never Forget. France, 1714: in a  (Read Online Books) The Invisible Life of Addie LaRue Thus begins the extraordinary life of Addie LaRue, and a dazzling adventure that will play out across centuries and continents, across history and art, as a young  The Invisible Life of Addie Larue (Large Print / Paperback October 2020 Indie Next List. “Epic, beautifully written, heartwarming, and heartbreaking, The Invisible Life of Addie LaRue is a contemplation  The Invisible Life of Addie LaRue by V. E. Schwab | James V The Invisible Life of Addie LaRue by V. E. Schwab. Dec 9, 2020. In a French village in 1714, a young desperate woman is being forced in to a marriage she does  The Invisible Life of Addie LaRue by V.E. Schwab ( A Review My Rating: 2 out of 5 stars ✨ Genre: Fantasy, Historical Fiction, Adult Fantasy. Year Of Publication: October 6th 2020. Publisher: Titan Books. 'The Invisible Life of Addie LaRue' is the top national fiction 'The Invisible Life of Addie LaRue' is the top national fiction bestseller · BESTSELLERS · As reported by Publishers Weekly · Hardcover fiction. Carolina reviews The Invisible Life of Addie LaRue by V.E. The Invisible Life of Addie LaRue is more of a character study than a romance; although Addie does not shy away from describing her female  The Invisible Life of Addie LaRue: A memorable book about Addie LaRue is a young woman in 18th Century France who yearns to be her own person, like the old woman outside town, Estele, “who belongs  The Invisible Life of Addie Larue In the vein of The Time Traveler's Wife and Life After Life, The Invisible Life of Addie LaRue is New York Times bestselling author V. E. Schwab's gen Details.
Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis
Creators: name: Reece, Jeff
name: Shears, Stephen B.
name: Gabriel, Sherif E.
name: Yang, Ling
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: A new aspect of research into the pathogenesis of cystic fibrosis (CF) is a genetics-based search for ;modifier genes' that may affect the severity of CF lung disease. Using an alternative, cell biological approach, we show that ITPK1 should be considered a modifier gene. ITPK1 synthesizes an intracellular signal, inositol (3,4,5,6)-tetrakisphosphate [Ins(3,4,5,6)P4]. A bio-activatable, cell-permeable analogue of Ins(3,4,5,6)P4 inhibited Ca2+-dependent secretion of Cl- from polarized monolayers of immortalized mouse tracheal epithelial cells (MTEs). Analysis by high-pressure liquid chromatography showed endogenous Ins(3,4,5,6)P4 levels in CF MTEs were approximately 60% below those in wild-type MTEs (P<0.03). This adaptation, which improves purinergic activation of Ca2+-dependent Cl- secretion in CF MTEs, was exceptionally specific; there was no effect upon the cellular levels of all the other inositol phosphate signals. Real-time PCR provided the explanation: the level of ITPK1 expression in wild-type MTEs was twice as high as that in CF MTEs (P<0.002). The biological impact of this differential gene expression is amplified by ITPK1 being concentrated at the apical membrane of MTEs, which we discovered following confocal immunofluorescence microscopy. Compartmentalization of Ins(3,4,5,6)P4 synthesis adjacent to its site of action will enhance its regulatory capacity.
Table S10 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Possible contamination scaffolds
Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle
Creators: name: Peifer, Mark
name: Jezuit, Erin
name: Price, Meredith H.
name: Roberts, David M.
name: McCartney, Brooke M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Many epithelial cells are polarized along the plane of the epithelium, a property termed planar cell polarity. The
Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin
Creators: name: Otey, Carol A.
name: Rachlin, Andrew S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Palladin is a recently described phosphoprotein with an important role in cytoskeletal organization. The major palladin isoform (90-92 kDa) binds to three actin-associated proteins (ezrin, VASP and [alpha]-actinin), suggesting that palladin functions as a cytoskeletal scaffold. Here, we describe the organization of the palladin gene, which encodes multiple isoforms, including one (140 kDa) with a similar localization pattern to 90 kDa palladin. Overexpression of the 90 kDa or 140 kDa isoforms in COS-7 cells results in rearrangements of the actin cytoskeleton into super-robust bundles and star-like arrays, respectively. Sequence analysis of 140 kDa palladin revealed a conserved binding site for SH3 domains, suggesting that it binds directly to the SH3-domain protein Lasp-1. Binding of 140 kDa palladin, but not 90 kDa palladin, to Lasp-1 was confirmed by yeast two-hybrid and GST-pull-down assays. Isoform-specific siRNA experiments suggested that 140 kDa palladin plays a role in recruiting Lasp-1 to stress fibers. These results add Lasp-1, an actin-binding protein with a crucial role in cell motility, to the growing list of palladin's binding partners, and suggest that 140 kDa palladin has a specialized function in organizing the actin arrays that participate in cell migration and/or cellular contractility.
[download pdf] Wellness: A novel by Nathan Hill
Creators: name: Jepson
Publisher: name: Zenodo
Year: 2024

description: Wellness: A novel by Nathan Hill

 

 

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Wellness: A novel

Nathan Hill

Page: 624

Format: pdf, ePub, mobi, fb2

ISBN: 9780593536117

Publisher: Knopf Doubleday Publishing Group

 

Download books google books free Wellness: A novel RTF MOBI English version

The Wellness Book Sporty & Rich. Physician Wellness: The Rock Star Doctor's Guide Physician Wellness: The Rock Star Doctor's Guide: Change Your Thinking, Improve Your Life (Rock Star Doctor Series) · Book overview. The Wellness Project by Phoebe Lapine This book is chock-full of easy-to-follow recipes, bursting with fresh flavors and produce.” —The Kitchn. “I was as charmed by this brilliant collection of  Wellness: A novel (Hardcover) - Folio Books 4 days ago — Health & Wellness: 9781284235197 Book details · ISBN-10. 128423519X · ISBN-13. 978-1284235197 · Edition. 14th · Publisher. Jones & Bartlett Learning · Publication date. May 10, 2022 · Language. Winfrey picks Nathan Hill's novel 'Wellness' for book club 4 days ago — The Wellness Mama Cookbook: 200 Easy-to-Prepare Book details ; Print length. 336 pages ; Language. English ; Publisher. Harmony ; Publication date. December 27, 2016 ; Dimensions. 7.62 x 1.09 x 9.51 inches. Book Review: 'Wellness,' by Nathan Hill 6 days ago — Wellness Book Lists Wellness Book Lists · Excellent Sheep: The Miseducation of the American Elite and the Way to a Meaningful Life · Manufacturing Consent: The Political Economy of  Wellness Against All Odds: Rogers, Sherry WELLNESS AGAINST ALL ODDS is the 6th and most revolutionary book by Sherry A. Rogers, M.D. It contains the ultimate healing plan that people have  Wellness by Nathan Hill This larger-than-life novel brims with heady ideas and the powerful emotional currents of a marriage slowly unraveling. Get yours when you join today! How the wellness industry hijacked self-care to exploit Sep 16, 2022 — The Wellness Book: The Comprehensive Guide to The Wellness Book shows readers how to create and control their own well being. Use of the book, in combination with modern medical treatments, will aid in
Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons
Creators: name: Meeker, Rick B.
name: Robertson, Brian W.
name: Cheney, Richard E.
name: Sousa, Aurea D.
name: Berg, Jonathan S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Although Myo10 (myosin-X) is an unconventional myosin associated with filopodia, little is known about its isoforms and roles in the nervous system. We report here that, in addition to full-length Myo10, brain expresses a shorter form of Myo10 that lacks a myosin head domain. This ;headless' Myo10 is thus unable to function as a molecular motor, but is otherwise identical to full-length Myo10 and, like it, contains three pleckstrin homology (PH) domains, a myosin-tail homology 4 (MyTH4) domain, and a band-4.1/ezrin/radixin/moesin (FERM) domain. Immunoblotting demonstrates that both full-length and headless Myo10 exhibit dramatic developmental regulation in mouse brain. Immunofluorescence with an antibody that detects both isoforms demonstrates that Myo10 is expressed in neurons, such as Purkinje cells, as well as non-neuronal cells, such as astrocytes and ependymal cells. CAD cells, a neuronal cell line, express both full-length and headless Myo10, and this endogenous Myo10 is present in cell bodies, neurites, growth cones and the tips of filopodia. To investigate the dynamics of the two forms of Myo10 in neurons, CAD cells were transfected with GFP constructs corresponding to full-length or headless Myo10. Only full-length Myo10 localizes to filopodial tips and undergoes intrafilopodial motility, demonstrating that the motor domain is necessary for these activities. Live cell imaging also reveals that full-length Myo10 localizes to the tips of neuronal filopodia as they explore and interact with their surroundings, suggesting that this myosin has a role in neuronal actin dynamics.
The Photonic Lantern
Creators: name: Birks, T. A.
name: Gris-Sánchez, I.
name: Yerolatsitis, S.
name: Leon-Saval, S. G.
name: Thomson, R. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Photonic lanterns are made by adiabatically merging several single-mode cores into one multimode core. They provide low-loss interfaces between single-mode and multimode systems where the precise optical mapping between cores and individual modes is unimportant.
description: 45 pages; article unchanged, accepted for publication in Advances in Optics and Photonics
Table S11 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Genomes used for orthologue identification
(2822) Mary Myers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
Creators: name: Walzer, Mark
name: Dedhar, Shoukat
name: Zhou, Jiang
name: Zhou, Feng Quan
name: Wu, Yao Hong
name: Snider, William D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Chondroitin sulfate proteoglycans (CSPGs) and myelin-based inhibitors are the most studied inhibitory molecules in the adult central nervous system. Unlike myelin-based inhibitors, few studies have reported ways to overcome the inhibitory effect of CSPGs. Here, by using regenerating adult dorsal root ganglion (DRG) neurons, we show that chondroitin sulfate proteoglycans inhibit axon assembly by a different mechanism from myelin-based inhibitors. Furthermore, we show that neither Rho inhibition nor cAMP elevation rescues extracellular factor-induced axon assembly inhibited by CSPGs. Instead, our data suggest that CSPGs block axon assembly by interfering with integrin signaling. Surprisingly, we find that nerve growth factor (NGF) promotes robust axon growth of regenerating DRG neurons over CSPGs. We have found that, unlike naive neurons that require simultaneous activation of neurotrophin and integrin pathways for axon assembly, either neurotrophin or integrin signaling alone is sufficient to induce axon assembly of regenerating neurons. Thus, our results suggest that the ability of NGF to overcome CSPG inhibition in regenerating neurons is probably due to the ability of regenerating neurons to assemble axons using an integrin-independent pathway. Finally, our data show that the GSK-3beta-APC pathway, previously shown to mediate developing axon growth, is also necessary for axon regeneration.
Additional file 1 of Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells
Creators: name: Pasquesi, Giulia Irene Maria
name: Kelly, Conor J.
name: Ordonez, Andrea D.
name: Chuong, Edward B.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Fig. S1. Myotis lucifugus embryonic fibroblast responsiveness to IFNa stimulation. Fig. S2. Myotis lucifugus genomic repeat element composition. Fig. S3. Myotis lucifugus total and recent TE transcriptome composition. Fig. S4. TE exonization events in Myotis ISGs. Fig. S5. A) Heatmaps showing normalized CUT&RUN signal (signal per million reads) over IFNainducible H3K27ac (unadjusted p-val < 0.10, log2FC > 0, n = 1113). B) Volcano plot visualizing family-level TE enrichment for IFNa-inducible (unadjusted p-val < 0.10, log2FC > 0) H3K27ac regions. TE families with a Fisher’s two-tailed p-val < 0.05 were defined as enriched (blue) or depleted (green) according to the reported odds ratio. Nonsignificant families are shown in grey. C) Heatmaps showing normalized CUT&RUN signal (signal per million reads) over IFNa-inducible (unadjusted p-val < 0.10, log2FC > 0) H3K27ac-marked L2 families. Fig. S6. Heatmaps showing normalized CUT&RUN signal (spike-in signal per million reads) over H3K27ac-marked A) MIR3 and B) AmnSINE1 families. Fig. S7. Reconstruction of the type I IFN locus.
Exploring positron characteristics utilizing two new positron-electron correlation schemes based on three electronic-structure calculation methods
Creators: name: Zhang, Wen-Shuai
name: Gu, Bing-Chuan
name: Han, Xiao-Xi
name: Liu, Jian-Dang
name: Ye, Bang-Jiao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We make a gradient correction to a new local density approximation form of positron-electron correlation. Then the positron lifetimes and affinities are probed by using these two approximation forms based on three electronic-structure calculation methods including the full-potential linearized augmented plane wave (FLAPW) plus local orbitals approach, the atomic superposition (ATSUP) approach and the projector augmented wave (PAW) approach. The differences between calculated lifetimes using the FLAPW and ATSUP methods are clearly interpreted in the view of positron and electron transfers. We further find that a well implemented PAW method can give near-perfect agreement on both the positron lifetimes and affinities with the FLAPW method, and the competitiveness of the ATSUP method against the FLAPW/PAW method is reduced within the best calculations. By comparing with experimental data, the new introduced gradient corrected correlation form is proved competitive for positron lifetime and affinity calculations.
description: 8 pages, 5 figures
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells
Creators: name: Garcia-Mata, Rafael
name: Arneman, Daniel
name: Goicoechea, Silvia
name: Otey, Carol A.
name: Scita, Giorgio
name: Disanza, Andrea
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Palladin is a widely expressed phosphoprotein that plays an important role in organizing the actin cytoskeleton. Palladin is concentrated in multiple actin-based structures involved in cell motility and adhesion, including stress fibers, focal adhesions, cell-cell junctions, growth cones and Z-discs. Here, we show that palladin also localizes to the dorsal, circular ruffles that form transiently in response to growth factor stimulation. More importantly, palladin knockdown results in decreased ruffle formation and decreased Rac activation following PDGF treatment. In addition, we describe a novel interaction between palladin and Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos-1. Eps8 was identified as a molecular partner for palladin in a yeast two-hybrid screen, and the interaction was confirmed biochemically in co-immunoprecipitation assays. The two proteins were found to colocalize extensively in dorsal ruffles. Palladin also localizes to podosomes after phorbol ester stimulation, and palladin knockdown results in decreased podosome formation in response to PDBu. Together, these data provide strong evidence for a direct and specific interaction between palladin and Eps8, and suggest that they act together in the rapid and transient remodeling of the actin cytoskeleton, which promotes the formation of highly dynamic membrane protrusions in response to PDGF and phorbol ester treatment.