cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection
Creators: name: Morrison, Thomas E.
name: Dundore, David Y.
name: Heise, Mark T.
name: Schultz-Cherry, Stacey
name: O'Brien, Kevin B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Highly pathogenic H5N1 influenza infections are associated with enhanced inflammatory and cytokine responses, severe lung damage, and an overall dysregulation of innate immunity. C3, a member of the complement system of serum proteins, is a major component of the innate immune and inflammatory responses. However, the role of this protein in the pathogenesis of H5N1 infection is unknown. Here we demonstrate that H5N1 influenza virus infected mice had increased levels of C5a and C3 activation byproducts as compared to mice infected with either seasonal or pandemic 2009 H1N1 influenza viruses. We hypothesized that the increased complement was associated with the enhanced disease associated with the H5N1 infection. However, studies in knockout mice demonstrated that C3 was required for protection from influenza infection, proper viral clearance, and associated with changes in cellular infiltration. These studies suggest that although the levels of complement activation may differ depending on the influenza virus subtype, complement is an important host defense mechanism.
Persua: A Visual Interactive System to Enhance the Persuasiveness of Arguments in Online Discussion
Creators: name: Xia, Meng
name: Zhu, Qian
name: Wang, Xingbo
name: Nie, Fei
name: Qu, Huamin
name: Ma, Xiaojuan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Persuading people to change their opinions is a common practice in online discussion forums on topics ranging from political campaigns to relationship consultation. Enhancing people's ability to write persuasive arguments could not only practice their critical thinking and reasoning but also contribute to the effectiveness and civility in online communication. It is, however, not an easy task in online discussion settings where written words are the primary communication channel. In this paper, we derived four design goals for a tool that helps users improve the persuasiveness of arguments in online discussions through a survey with 123 online forum users and interviews with five debating experts. To satisfy these design goals, we analyzed and built a labeled dataset of fine-grained persuasive strategies (i.e., logos, pathos, ethos, and evidence) in 164 arguments with high ratings on persuasiveness from ChangeMyView, a popular online discussion forum. We then designed an interactive visual system, Persua, which provides example-based guidance on persuasive strategies to enhance the persuasiveness of arguments. In particular, the system constructs portfolios of arguments based on different persuasive strategies applied to a given discussion topic. It then presents concrete examples based on the difference between the portfolios of user input and high-quality arguments in the dataset. A between-subjects study shows suggestive evidence that Persua encourages users to submit more times for feedback and helps users improve more on the persuasiveness of their arguments than a baseline system. Finally, a set of design considerations was summarized to guide future intelligent systems that improve the persuasiveness in text.
description: This paper will appear in CSCW 2022
A Single Amino Acid in the HA of pH1N1 2009 Influenza Virus Affects Cell Tropism in Human Airway Epithelium, but Not Transmission in Ferrets
Creators: name: Barclay, Wendy S.
name: Shelton, Holly
name: Roberts, Kim L.
name: Pickles, Ray J.
name: van Doremalen, Neeltje
name: Jones, Ian M.
name: Thompson, Catherine I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The first pandemic of the 21st century, pandemic H1N1 2009 (pH1N1 2009), emerged from a swine-origin source. Although human infections with swine-origin influenza have been reported previously, none went on to cause a pandemic or indeed any sustained human transmission. In previous pandemics, specific residues in the receptor binding site of the haemagglutinin (HA) protein of influenza have been associated with the ability of the virus to transmit between humans. In the present study we investigated the effect of residue 227 in HA on cell tropism and transmission of pH1N1 2009. In pH1N1 2009 and recent seasonal H1N1 viruses this residue is glutamic acid, whereas in swine influenza it is alanine. Using human airway epithelium, we show a differential cell tropism of pH1N1 2009 compared to pH1N1 2009 E227A and swine influenza suggesting this residue may alter the sialic acid conformer binding preference of the HA. Furthermore, both pH1N1 2009 E227A and swine influenza multi-cycle viral growth was found to be attenuated in comparison to pH1N1 2009 in human airway epithelium. However this altered tropism and viral growth in human airway epithelium did not abrogate respiratory droplet transmission of pH1N1 2009 E227A in ferrets. Thus, acquisition of E at residue 227 was not solely responsible for the ability of pH1N1 2009 to transmit between humans.
Weakly periodic Gibbs measures Of HC-model for normal divisor of the index four
Creators: name: Khakimov, Rustam
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this paper is studied HC-model on a Cayley tree and under some conditions on parameters of the HC-model we prove existence of the weakly periodic (non periodic) Gibbs measures for normal divisor of the index four.
Assess for success: evidence for therapeutic assessment
Creators: name: Hersh, Deborah
name: Worrall, Linda
name: O'Halloran, Robyn
name: Brown, Kyla
name: Crohn, Brooke
name: Rodriguez, Amy D
Publisher: name: La Trobe
Year: 2023

description: This is a book chapter dealing with augmentative and alternative communication for suffers of aphasia.
A Spatial Analysis of County-level Variation in Syphilis and Gonorrhea in Guangdong Province, China
Creators: name: Chen, Xiang-Sheng
name: Tucker, Joseph D.
name: Tan, Nicholas X.
name: Emch, Michael
name: Yang, Li-Gang
name: Yang, Bin
name: Cohen, Myron S.
name: Messina, Jane P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundSexually transmitted infections (STI) have made a resurgence in many rapidly developing regions of southern China, but there is little understanding of the social changes that contribute to this spatial distribution of STI. This study examines county-level socio-demographic characteristics associated with syphilis and gonorrhea in Guangdong Province.Methods/Principal FindingsThis study uses linear regression and spatial lag regression to determine county-level (n = 97) socio-demographic characteristics associated with a greater burden of syphilis, gonorrhea, and a combined syphilis/gonorrhea index. Data were obtained from the 2005 China Population Census and published public health data. A range of socio-demographic variables including gross domestic product, the Gender Empowerment Measure, standard of living, education level, migrant population and employment are examined. Reported syphilis and gonorrhea cases are disproportionately clustered in the Pearl River Delta, the central region of Guangdong Province. A higher fraction of employed men among the adult population, higher fraction of divorced men among the adult population, and higher standard of living (based on water availability and people per room) are significantly associated with higher STI cases across all three models. Gross domestic product and gender inequality measures are not significant predictors of reported STI in these models.Conclusions/SignificanceAlthough many ecological studies of STIs have found poverty to be associated with higher reported STI, this analysis found a greater number of reported syphilis cases in counties with a higher standard of living. Spatially targeted syphilis screening measures in regions with a higher standard of living may facilitate successful control efforts. This analysis also reinforces the importance of changing male sexual behaviors as part of a comprehensive response to syphilis control in China.
Canadian Gallup Poll # 442-1
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); rating professions according to their desirability(1); conversion to metric system(3); education(2); acid rain(4); privatizing PetroCanada(3); immigration to Canada(2); unemployment(2); Prime Minister and the opposition leader job performance(3). Note: Demographics(15).
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
Creators: name: Leffler, Nancy R.
name: Asch, Adam S.
name: Witte, Owen N.
name: Dong, Lixue
name: Yang, Li V.
name: Chen, Aishe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. Using molecular, cellular and biochemical approaches, we demonstrate that activation of GPR4, a proton-sensing G protein-coupled receptor, by isocapnic acidosis increases the adhesiveness of human umbilical vein endothelial cells (HUVECs) that express GPR4 endogenously. Acidosis in combination with GPR4 overexpression further augments HUVEC adhesion with U937 monocytes. In contrast, overexpression of a G protein signaling-defective DRY motif mutant (R115A) of GPR4 does not elicit any increase of HUVEC adhesion, indicating the requirement of G protein signaling. Downregulation of GPR4 expression by RNA interference reduces the acidosis-induced HUVEC adhesion. To delineate downstream pathways, we show that inhibition of adenylate cyclase by inhibitors, 2′,5′-dideoxyadenosine (DDA) or SQ 22536, attenuates acidosis/GPR4-induced HUVEC adhesion. Consistently, treatment with a cAMP analog or a Gi signaling inhibitor increases HUVEC adhesiveness, suggesting a role of the Gs/cAMP signaling in this process. We further show that the cAMP downstream effector Epac is important for acidosis/GPR4-induced cell adhesion. Moreover, activation of GPR4 by acidosis increases the expression of vascular adhesion molecules E-selectin, VCAM-1 and ICAM-1, which are functionally involved in acidosis/GPR4-mediated HUVEC adhesion. Similarly, hypercapnic acidosis can also activate GPR4 to stimulate HUVEC adhesion molecule expression and adhesiveness. These results suggest that acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the Gs/cAMP/Epac pathway and may play a role in the inflammatory response of vascular endothelial cells.
Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing
Creators: name: Arenkiel, Benjamin R.
name: Wang, Fan
name: Philpot, Benjamin D.
name: Larsen, Rylan S.
name: Wallace, Michael L.
name: Hasegawa, Hiroshi
name: Yi, Jason J.
name: Ehlers, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The continued addition of new neurons to mature olfactory circuits represents a remarkable mode of cellular and structural brain plasticity. However, the anatomical configuration of newly established circuits, the types and numbers of neurons that form new synaptic connections, and the effect of sensory experience on synaptic connectivity in the olfactory bulb remain poorly understood. Using in vivo electroporation and monosynaptic tracing, we show that postnatal-born granule cells form synaptic connections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb. In addition, newly born granule cells receive extensive input from local inhibitory short axon cells, a poorly understood cell population. The connectivity of short axon cells shows clustered organization, and their synaptic input onto newborn granule cells dramatically and selectively expands with odor stimulation. Our findings suggest that sensory experience promotes the synaptic integration of new neurons into cell type-specific olfactory circuits.
Adenomatous Polyposis Coli Regulates Axon Arborization and Cytoskeleton Organization via Its N-Terminus
Creators: name: Tian, Xu
name: Snider, William D.
name: Kim, Woo-Yang
name: Chen, Youjun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Conditional deletion of APC leads to marked disruption of cortical development and to excessive axonal branching of cortical neurons. However, little is known about the cell biological basis of this neuronal morphological regulation. Here we show that APC deficient cortical neuronal growth cones exhibit marked disruption of both microtubule and actin cytoskeleton. Functional analysis of the different APC domains revealed that axonal branches do not result from stabilized β-catenin, and that the C-terminus of APC containing microtubule regulatory domains only partially rescues the branching phenotype. Surprisingly, the N-terminus of APC containing the oligomerization domain and the armadillo repeats completely rescues the branching and cytoskeletal abnormalities. Our data indicate that APC is required for appropriate axon morphological development and that the N-terminus of APC is important for regulation of the neuronal cytoskeleton.
Boson Sampling for Generalized Bosons
Creators: name: Kuo, En-Jui
name: Xu, Yijia
name: Hangleiter, Dominik
name: Grankin, Andrey
name: Hafezi, Mohammad
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce the notion of "generalized bosons" whose exchange statistics resemble those of bosons, but the local bosonic commutator $[a_i,a_i^\dagger]=1$ is replaced by an arbitrary single-mode operator that is diagonal in the generalized Fock basis. Examples of generalized bosons include boson pairs and spins. We consider the analogue of the boson sampling task for these particles and observe that its output probabilities are still given by permanents, so that the results regarding hardness of sampling directly carry over. Finally, we propose implementations of generalized boson sampling in circuit-QED and ion-trap platforms.
description: Fixed typos and added references. 6 pages, 1 figure + 9 pages supplemental material
Interface induced states at the boundary between a 3D topological insulator Bi$_2$Se$_3$ and a ferromagnetic insulator EuS
Creators: name: Eremeev, S. V.
name: Men'shov, V. N.
name: Tugushev, V. V.
name: Chulkov, E. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: By means of relativistic density functional theory (DFT) calculations we study electron band structure of the topological insulator (TI) Bi$_2$Se$_3$ thin films deposited on the ferromagnetic insulator (FMI) EuS substrate. In the Bi$_2$Se$_3$/EuS heterostructure, the gap opened in the spectrum of the topological state has a hybridization character and is shown to be controlled by the Bi$_2$Se$_3$ film thickness, while magnetic contribution to the gap is negligibly small. We also analyzed the effect of Eu doping on the magnetization of the Bi$_2$Se$_3$ film and demonstrated that the Eu impurity induces magnetic moments on neighboring Se and Bi atoms an order of magnitude larger than the substrate-induced moments. Recent magnetic and magneto-transport measurements in EuS/Bi$_2$Se$_3$ heterostructure are discussed.
description: submitted to Special issue (MISM-2014, 29 June - 3 July 2014, Moscow) in Journal of Magnetism and Magnetic Materials
Utilizing the null stream of the Einstein Telescope
Creators: name: Goncharov, Boris
name: Nitz, Alexander H.
name: Harms, Jan
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Among third-generation ground-based gravitational-wave detectors proposed for the next decade, the Einstein Telescope provides a unique kind of null stream $\unicode{x2014}$ the signal-free linear combination of data $\unicode{x2014}$ that enables otherwise inaccessible tests of the noise models. We project and showcase challenges in modeling the noise in the 2030s and how it will affect the performance of third-generation detectors. We find that the null stream of the Einstein Telescope is capable of eliminating transient detector glitches that are known to limit current gravitational-wave searches. The techniques we discuss are computationally efficient and do not require a priori knowledge about glitch models. Furthermore, we show how the null stream can be used to provide an unbiased estimation of the noise power spectrum necessary for online and offline data analyses even with multiple loud signals in the band. We overview other approaches to utilizing the null stream. Finally, we comment on the limitations and future challenges of null-stream analyses for the Einstein Telescope and arbitrary detector networks.
description: 15 pages, 7 figures
Adhesive F-actin Waves: A Novel Integrin-Mediated Adhesion Complex Coupled to Ventral Actin Polymerization
Creators: name: Case, Lindsay B.
name: Waterman, Clare M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: At the leading lamellipodium of migrating cells, protrusion of an Arp2/3-nucleated actin network is coupled to formation of integrin-based adhesions, suggesting that Arp2/3-mediated actin polymerization and integrin-dependent adhesion may be mechanistically linked. Arp2/3 also mediates actin polymerization in structures distinct from the lamellipodium, in “ventral F-actin waves” that propagate as spots and wavefronts along the ventral plasma membrane. Here we show that integrins engage the extracellular matrix downstream of ventral F-actin waves in several mammalian cell lines as well as in primary mouse embryonic fibroblasts. These “adhesive F-actin waves” require a cycle of integrin engagement and disengagement to the extracellular matrix for their formation and propagation, and exhibit morphometry and a hierarchical assembly and disassembly mechanism distinct from other integrin-containing structures. After Arp2/3-mediated actin polymerization, zyxin and VASP are co-recruited to adhesive F-actin waves, followed by paxillin and vinculin, and finally talin and integrin. Adhesive F-actin waves thus represent a previously uncharacterized integrin-based adhesion complex associated with Arp2/3-mediated actin polymerization.
British Gallup Poll: CQ 043A
Creators: name: Social Surveys (Gallup Poll) Limited
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Government approval rating(1); Thatcher approval rating(1); political party leaders(2); political party(2); 1987 election(2); Iraq's economic blockade(8); Gulf miltary action(5); Gulf crisis(4).
Mono vs Multilingual BERT for Hate Speech Detection and Text Classification: A Case Study in Marathi
Creators: name: Velankar, Abhishek
name: Patil, Hrushikesh
name: Joshi, Raviraj
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Transformers are the most eminent architectures used for a vast range of Natural Language Processing tasks. These models are pre-trained over a large text corpus and are meant to serve state-of-the-art results over tasks like text classification. In this work, we conduct a comparative study between monolingual and multilingual BERT models. We focus on the Marathi language and evaluate the models on the datasets for hate speech detection, sentiment analysis and simple text classification in Marathi. We use standard multilingual models such as mBERT, indicBERT and xlm-RoBERTa and compare with MahaBERT, MahaALBERT and MahaRoBERTa, the monolingual models for Marathi. We further show that Marathi monolingual models outperform the multilingual BERT variants on five different downstream fine-tuning experiments. We also evaluate sentence embeddings from these models by freezing the BERT encoder layers. We show that monolingual MahaBERT based models provide rich representations as compared to sentence embeddings from multi-lingual counterparts. However, we observe that these embeddings are not generic enough and do not work well on out of domain social media datasets. We consider two Marathi hate speech datasets L3Cube-MahaHate, HASOC-2021, a Marathi sentiment classification dataset L3Cube-MahaSent, and Marathi Headline, Articles classification datasets.
Canadian Gallup Omnibus Poll # 010-2
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal and provincial elections vote intent(2); past federal and provincial elections vote(2); federal government job performance(2); Prime Minister and the opposition leader job performanc(3); Canadian Senate(3); withdrawal of Canadian troops from Europe(1). Note: Standard demographics(17).
Performance Evaluation of Action Recognition Models on Low Quality Videos
Creators: name: Otani, Aoi
name: Hashiguchi, Ryota
name: Omi, Kazuki
name: Fukushima, Norishige
name: Tamaki, Toru
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In the design of action recognition models, the quality of videos is an important issue; however, the trade-off between the quality and performance is often ignored. In general, action recognition models are trained on high-quality videos, hence it is not known how the model performance degrades when tested on low-quality videos, and how much the quality of training videos affects the performance. The issue of video quality is important, however, it has not been studied so far. The goal of this study is to show the trade-off between the performance and the quality of training and test videos by quantitative performance evaluation of several action recognition models for transcoded videos in different qualities. First, we show how the video quality affects the performance of pre-trained models. We transcode the original validation videos of Kinetics400 by changing quality control parameters of JPEG (compression strength) and H.264/AVC (CRF). Then we use the transcoded videos to validate the pre-trained models. Second, we show how the models perform when trained on transcoded videos. We transcode the original training videos of Kinetics400 by changing the quality parameters of JPEG and H.264/AVC. Then we train the models on the transcoded training videos and validate them with the original and transcoded validation videos. Experimental results with JPEG transcoding show that there is no severe performance degradation (up to -1.5%) for compression strength smaller than 70 where no quality degradation is visually observed, and for larger than 80 the performance degrades linearly with respect to the quality index. Experiments with H.264/AVC transcoding show that there is no significant performance loss (up to -1%) with CRF30 while the total size of video files is reduced to 30%.
description: IEEE Access, vol. 10, pp. 94898-94907, 2022
Canadian Gallup Omnibus Poll # 101-1
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal and provincial elections vote intent(2); past federal and provincial elections vote(2); greatest problem facing Canada(1); Canada's position on Persian Gulf war(1); Quebec's separatism(4); public impressions of world leaders(6); standard of living(1); shops open on Sundays(7); St.Valentine's Day(3); confidence in Canadian social institutions(6); greatest threat to Canada: big business, labor or government(1); economic conditions(5); unemployment(2). Note: Standard demographics(17).
An Empirical Analysis of Overlap Publication in Chinese Language and English Research Manuscripts
Creators: name: Luo, Jing
name: Zhang, Xiaoxi
name: Lin, Margaret
name: Brandt, Allison
name: Gao, Xing
name: Sun, Kai
name: Chang, Helena
name: Song, Philip
name: Tucker, Joseph D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundThere are a number of sound justifications for publishing nearly identical information in Chinese and English medical journals, assuming several conditions are met. Although overlap publication is perceived as undesirable and ethically questionable in Europe and North America, it may serve an important function in some regions where English is not the native tongue. There is no empirical data on the nature and degree of overlap publication in English and Chinese language journals.Methods/Principal FindingsA random sample of 100 English manuscripts from Chinese institutions was selected from PubMed. Key words and institutions were searched in the China National Knowledge Infrastructure, a comprehensive Chinese language research database. Unacknowledged overlap was a priori defined according to International Committee of Medical Journal Editor (ICMJE) guidelines following examination by two individuals. 19% (95% CI 11–27) of English manuscripts from Chinese institutions were found to have substantial overlap with Chinese published work based on full text examination. None of the manuscripts met all of the criteria established by the ICMJE for an acknowledged overlap publication. Individual-level, journal-level, and institutional factors seem to influence overlap publication. Manuscripts associated with an institution outside of China and with more than one institution were significantly less likely to have substantial overlap (p<0.05).Conclusions/SignificanceOverlap publication was common in this context, but instances of standard ICMJE notations to acknowledge this practice were rare. This research did not cite the identified overlap manuscripts with the hope that these empirical data will inform journal policy changes and structural initiatives to promote clearer policies and manuscripts.
Mobile recommender systems: An overview of technologies and challenges
Creators: name: Polatidis, Nikolaos
name: Georgiadis, Christos K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: The use of mobile devices in combination with the rapid growth of the internet has generated an information overload problem. Recommender systems is a necessity to decide which of the data are relevant to the user. However in mobile devices there are different factors who are crucial to information retrieval, such as the location, the screen size and the processor speed. This paper gives an overview of the technologies related to mobile recommender systems and a more detailed description of the challenged faced.
description: The final publication is available at IEEE xplore http://ieeexplore.ieee.org/xpl/articleDetails.jsp?tp=&arnumber=6650270&url=http%3A%2F%2Fieeexplore.ieee.org%2Fxpls%2Fabs_all.jsp%3Farnumber%3D6650270
Gravitational waveform model based on photon motion for spinning black holes
Creators: name: Li, Song
name: Han, Wen-Biao
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The waveforms from binary black hole mergers include inspiral, merger, and ringdown parts. Usually, the inspiral waveform can be obtained by calibrating from post-Newtonian approximation; The merger and ringdown ones can be gotten from the quasinormal modes with black hole perturbation theory. However, for more general black holes, the calculation of the quasinormal modes is not trivial. In this paper we use the photon sphere to get the quasinormal modes of spinning black holes. Then we connect the ringdown wave with the inspiral part to get full waveforms and compare with the ones from numerical relativity. We find that they match with each other very well. In principle this method can be extended to some general compact objects. As an example, the ringdown waveforms from parametrized axisymmetric black holes are obtained. We also use this method to get the ringdown signals of the accelerating final black hole; this is due to gravitational recoil during the merger. Even for the extreme cases, the acceleration due to the recoil cannot produce detectable effects.
description: 14 pages, 12 figures
Anchored Design of Protein-Protein Interfaces
Creators: name: Kuhlman, Brian A.
name: Lewis, Steven M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundFew existing protein-protein interface design methods allow for extensive backbone rearrangements during the design process. There is also a dichotomy between redesign methods, which take advantage of the native interface, and de novo methods, which produce novel binders.MethodologyHere, we propose a new method for designing novel protein reagents that combines advantages of redesign and de novo methods and allows for extensive backbone motion. This method requires a bound structure of a target and one of its natural binding partners. A key interaction in this interface, the anchor, is computationally grafted out of the partner and into a surface loop on the design scaffold. The design scaffold's surface is then redesigned with backbone flexibility to create a new binding partner for the target. Careful choice of a scaffold will bring experimentally desirable characteristics into the new complex. The use of an anchor both expedites the design process and ensures that binding proceeds against a known location on the target. The use of surface loops on the scaffold allows for flexible-backbone redesign to properly search conformational space.Conclusions and SignificanceThis protocol was implemented within the Rosetta3 software suite. To demonstrate and evaluate this protocol, we have developed a benchmarking set of structures from the PDB with loop-mediated interfaces. This protocol can recover the correct loop-mediated interface in 15 out of 16 tested structures, using only a single residue as an anchor.
Collapse of an ecological network in Ancient Egypt
Creators: name: Yeakel, Justin D.
name: Pires, Mathias M.
name: Rudolf, Lars
name: Dominy, Nathaniel J.
name: Koch, Paul L.
name: Guimarães, Paulo R.
name: Gross, Thilo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: The dynamics of ecosystem collapse are fundamental to determining how and why biological communities change through time, as well as the potential effects of extinctions on ecosystems. Here we integrate depictions of mammals from Egyptian antiquity with direct lines of paleontological and archeological evidence to infer local extinctions and community dynamics over a 6000-year span. The unprecedented temporal resolution of this data set enables examination of how the tandem effects of human population growth and climate change can disrupt mammalian communities. We show that the extinctions of mammals in Egypt were nonrandom, and that destabilizing changes in community composition coincided with abrupt aridification events and the attendant collapses of some complex societies. We also show that the roles of species in a community can change over time, and that persistence is predicted by measures of species sensitivity, a function of local dynamic stability. Our study is the first high-resolution analysis of the ecological impacts of environmental change on predator-prey networks over millennial timescales, and sheds light on the historical events that have shaped modern animal communities.
Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
Creators: name: Rogerson, Stephen J.
name: Molyneux, Malcolm E.
name: Ataíde, Ricardo
name: Mwapasa, Victor
name: Meshnick, Steven R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2VSA were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2VSA did not. Phagocytic antibodies to CS2VSA are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity.
Bocavirus Episome in Infected Human Tissue Contains Non-Identical Termini
Creators: name: Williams, Brent
name: Lipkin, W. Ian
name: Hornig, Mady
name: Henriquez, Jose A.
name: Kapoor, Amit
name: Asokan, Aravind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Human bocaviruses (HBoV) are highly prevalent human infections whose pathogenic potential remains unknown. Recent identification of the first non-human primate bocavirus [1] in captive gorillas raised the possibility of the persistent nature of bocavirus infection. To characterize bocavirus infection in humans, we tested intestinal biopsies from 22 children with gastrointestinal disease for the presence of HBoV DNA. Four HBoV-positive tissue samples were analyzed to determine whether viral DNA was present in the linear genomic, the episomal closed circular or the host genome-integrated form. Whereas one tissue sample positive for HBoV3 contained the episomal form (HBoV3-E1), none had the genome-integrated form. The complete genome sequence of HBoV3-E1 contains 5319 nucleotides of which 513 represent the non-coding terminal sequence. The secondary structure of HBoV3-E1 termini suggests several conserved and variable features among human and animal bocaviruses. Our observation that HBoV genome exists as head-to-tail monomer in infected tissue either reflects the likely evolution of alternative replication mechanism in primate bocaviruses or a mechanism of viral persistence in their host. Moreover, we identified the HBoV genomic terminal sequences that will be helpful in developing reverse genetic systems for these widely prevalent parvoviruses.
Heat transfer enhancement in turbulent boundary layers with a pulsed slot jet in crossflow
Creators: name: Castellanos, Rodrigo
name: Salih, Gianfranco
name: Raiola, Marco
name: Ianiro, Andrea
name: Discetti, Stefano
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The convective heat transfer enhancement in a turbulent boundary layer (TBL) employing a pulsed, slot jet in crossflow is investigated experimentally. A parametric study on actuation frequencies and duty cycles is performed. The actuator is a flush-mounted slot jet that injects fluid into a well-behaved zero-pressure-gradient TBL over a flat plate. A heated-thin-foil sensor measures the time-averaged convective heat transfer coefficient downstream of the actuator location and the flow field is characterised by means of Particle Image Velocimetry. The results show that both the jet penetration in the streamwise direction and the overall Nusselt number increase with increasing duty cycle. The frequency at which the Nusselt number is maximised is independent of the duty cycle. The flow topology is considerably altered by the jet pulsation. A wall-attached jet rises from the slot accompanied by a pair of counter-rotating vortices that promote flow entrainment and mixing. Eventually, a simplified model is proposed which decouples the effect of pulsation frequency and duty cycle in the overall heat transfer enhancement, with a good agreement with experimental data. The cost of actuation is also quantified in terms of the amount of injected fluid during the actuation, leading to conclude that the lowest duty cycle is the most efficient for heat transfer enhancement.
Canadian Gallup Omnibus Poll # 022Y
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Voting intentions(2); voting record(2); influence of polls on voting(2); political leaders(2); electoral system preferemce(1); official opposition party(1); Prime Minister responsibilities(1); economic plan(1); taxation(1),
Common Minor Histocompatibility Antigen Discovery Based upon Patient Clinical Outcomes and Genomic Data
Creators: name: Molldrem, Jeffrey J.
name: Alatrash, Gheath
name: Hunsucker, Sally A.
name: St. John, Lisa
name: Van Bergen, Cornelis A. M.
name: Li, Hua
name: Falkenburg, J. H. Frederik
name: Armistead, Paul M.
name: Sarantopoulos, Stefanie
name: Liang, Shoudan
name: Lu, Sijie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundMinor histocompatibility antigens (mHA) mediate much of the graft vs. leukemia (GvL) effect and graft vs. host disease (GvHD) in patients who undergo allogeneic stem cell transplantation (SCT) [1], [2], [3], [4]. Therapeutic decision making and treatments [5] based upon mHAs will require the evaluation of multiple candidate mHAs and the selection of those with the potential to have the greatest impact on clinical outcomes. We hypothesized that common, immunodominant mHAs, which are presented by HLA-A, B, and C molecules, can mediate clinically significant GvL and/or GvHD, and that these mHAs can be identified through association of genomic data with clinical outcomes.Methodology/Principal FindingsBecause most mHAs result from donor/recipient cSNP disparities, we genotyped 57 myeloid leukemia patients and their donors at 13,917 cSNPs [6]. We correlated the frequency of genetically predicted mHA disparities with clinical evidence of an immune response and then computationally screened all peptides mapping to the highly associated cSNPs for their ability to bind to HLA molecules. As proof-of-concept, we analyzed one predicted antigen, T4A, whose mHA mismatch trended towards improved overall and disease free survival in our cohort. T4A mHA mismatches occurred at the maximum theoretical frequency for any given SCT. T4A-specific CD8+ T lymphocytes (CTLs) were detected in 3 of 4 evaluable post-transplant patients predicted to have a T4A mismatch.Conclusions/SignificanceOur method is the first to combine clinical outcomes data with genomics and bioinformatics methods to predict and confirm a mHA. Refinement of this method should enable the discovery of clinically relevant mHAs in the majority of transplant patients and possibly lead to novel immunotherapeutics [5].
High-field charge transport on the surface of Bi$_2$Se$_3$
Creators: name: Weng, M. Q.
name: Wu, M. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theoretical study on the high-field charge transport on the surface of Bi$_2$Se$_3$ and reproduce all the main features of the recent experimental results, i.e., the incomplete current saturation and the finite residual conductance in the high applied field regime [Costache {\it et al.}, Phys. Rev. Lett. {\bf 112}, 086601 (2014)]. Due to the hot-electron effect, the conductance decreases and the current shows the tendency of the saturation with the increase of the applied electric field. Moreover, the electric field can excite carriers within the surface bands through interband precession and leads to a higher conductance. As a joint effect of the hot-electron transport and the carrier excitation, the conductance approaches a finite residual value in the high-field regime and the current saturation becomes incomplete. We thus demonstrate that, contrary to the conjecture in the literature, the observed transport phenomena can be understood qualitatively in the framework of surface transport alone. Furthermore, if a constant bulk conductance which is insensitive to the field is introduced, one can obtain a good quantitative agreement between the theoretical results and the experimental data.
description: 6 pages, 1 figure
Ébauche d'un inventaire des Hétéroptères (Insecta, Hemiptera, Heteroptera) de l'Eurométropole de Strasbourg (Alsace, France)
Creators: name: Callot, Henry
Publisher: name: SHNEC [Société d'Histoire Naturelle et d'Ethnographie de Colmar]
Year: 2024
Subjects: Entomology

description: Résumé  ̶  La liste des espèces d'Hétéroptères présentes dans les limites de l'Eurométropole de Strasbourg (Alsace, France) a été établie en fonction des données disponibles jusqu'en juin 2024. Leur diversité, 361 espèces recensées, et leur abondance sont présentées et discutées pour chaque secteur de l'agglomération, zones urbaines, espaces ouverts agricoles, prés, zones humides ou forêts.Mots-clés  ̶  Hétéroptères, Eurométropole Strasbourg, Alsace, France.Abstract  ̶  Provisional checklist of bugs (Insecta, Hemiptera, Heteroptera) of the Eurometropole of Strasbourg (Alsace, France)The checklist of Heteroptera species present within the limits of the Eurométropole de Strasbourg (Alsace, France) was based on the data available until June 2024. Their diversity, 361 recorded species, and their abundance are presented and discussed for each district of the agglomeration, urban areas, agricultural spaces, meadows, wetlands or woods.Keywords  ̶  Heteroptera, Eurométropole Strasbourg, Alsace, France.
LOv-Calculus: A Graphical Language for Linear Optical Quantum Circuits
Creators: name: Clément, Alexandre
name: Heurtel, Nicolas
name: Mansfield, Shane
name: Perdrix, Simon
name: Valiron, Benoît
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We introduce the LOv-calculus, a graphical language for reasoning about linear optical quantum circuits with so-called vacuum state auxiliary inputs. We present the axiomatics of the language and prove its soundness and completeness: two LOv-circuits represent the same quantum process if and only if one can be transformed into the other with the rules of the LOv-calculus. We give a confluent and terminating rewrite system to rewrite any polarisation-preserving LOv-circuit into a unique triangular normal form, inspired by the universal decomposition of Reck et al. (1994) for linear optical quantum circuits.
2alpha+t cluster feature of $3/2^-_3$ state in $^{11}$B
Creators: name: Kanada-En'yo, Yoshiko
name: Suhara, Tadahiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We reanalyze $2α+t$ cluster features of $3/2^-$ states in $^{11}$B by investigating the $t$ cluster distribution around a $2α$ core in $^{11}$B, calculated with the method of antisymmetrized molecular dynamics (AMD). In the $3/2^-_3$ state, a $t$ cluster is distributed in a wide region around $2α$, indicating that the $t$ cluster moves rather freely in angular as well as radial motion. From the weak angular correlation and radial extent of the $t$ cluster distribution, we propose an interpretation of a $2α+t$ cluster gas for the $3/2^-_3$ state. In this study, we compare the $2α+t$ cluster feature in $^{11}$B($3/2^-_3$) with the $3α$ cluster feature in $^{12}$C($0^+_2$), and discuss their similarities and differences.
description: 14 pages, 11 figures
Complex Deleterious Interactions Associated with Malic Enzyme May Contribute to Reproductive Isolation in the Copepod Tigriopus californicus
Creators: name: Willett, Christopher S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Dobzhansky-Muller incompatibilities can result from the interactions of more than a single pair of interacting genes and there are several different models of how such complex interactions can be structured. Previous empirical work has identified complex conspecific epistasis as a form of complex interaction that has contributed to postzygotic reproductive isolation between taxa, but other forms of complexity are also possible. Here, I probe the genetic basis of reproductive isolation in crosses of the intertidal copepod Tigriopus californicus by looking at the impact of markers in genes encoding metabolic enzymes in F2 hybrids. The region of the genome associated with the locus ME2 is shown to have strong, repeatable impacts on the fitness of hybrids in crosses and epistatic interactions with another chromosomal region marked by the GOT2 locus in one set of crosses. In a cross between one of these populations and a third population, these two regions do not appear to interact despite the continuation of a large effect of the ME2 region itself in both crosses. The combined results suggest that the ME2 chromosomal region is involved in incompatibilities with several unique partners. If these deleterious interactions all stem from the same factor in this region, that would suggest a different form of complexity from complex conspecific epistasis, namely, multiple independent deleterious interactions stemming from the same factor. Confirmation of this idea will require more fine-scale mapping of the interactions of the ME2 region of the genome.
Delayed Versus Immediate Placement of Direct Resin Composite Restorations Following Vital Pulp Therapy with ProRoot® Mineral Trioxide Aggregate or Biodentine™: A Review of the Literature
Creators: name: Nattakan Chaipattanawan
Publisher: name: Faculty of Dentistry, Chiang Mai University
Year: 2021
Subjects: Biodentine™
delayed versus immediate placement
direct resin composite restorations
ProRoot® MTA
vital pulp therapy

description: Chiang Mai Dental Journal, 42, 2, 44-58
Cross-Sectional Detection of Acute HIV Infection: Timing of Transmission, Inflammation and Antiretroviral Therapy
Creators: name: Mayo, Ashley J.
name: Borrow, Persephone
name: Dibben, Oliver
name: Haynes, Barton
name: Swanstrom, Ronald
name: Eron, Joseph J.
name: Cohen, Myron S.
name: Hicks, Charles
name: Kuruc, JoAnn D.
name: Keele, Brandon F.
name: Li, Hui
name: Gay, Cynthia
name: Stacey, Andrea
name: Norris, Philip J.
name: Salazar-Gonzalez, Jesus F.
name: Margolis, David
name: Shaw, George M.
name: Hahn, Beatrice H.
name: Anderson, Jeffrey A.
name: Ferrari, Guido
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Acute HIV infection (AHI) is a critical phase of infection when irreparable damage to the immune system occurs and subjects are very infectious. We studied subjects with AHI prospectively to develop better treatment and public health interventions.