cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
John Boyle O'Reilly and Moondyne (1878)
Creators: name: Ashton, Susanna Margaret
Publisher: name: Humanities Commons
Year: 2002
Subjects: subject: Australian literature
subject: American literature
subject: Irish literature

description: Arrested for treason against the British Crown and deported to the penal colonies of Australia, the Irish revolutionary John Boyle O'Reilly managed to escape to the United States and within a few years became one of Boston's most prominent political and literary figures, one of the best known Irish immigrants in the United States and one of the most charismatic individuals of the late nineteenth century. He wrote some of the most popular poetry of the period as well as one obscure but swashbuckling novel, Moondyne (1878), based in part upon the spectacular events of his own life.   O Reilly was a hero of national and international stature.  His reputation, however, rested on more than his personal charism, staggering life history and notorious achievements as political activist and editor of The Pilor, the most influential Catholic newspaper of the nineteenth century.  His clout truly stemmed from the way in which other Americans saw him as embodying a cultural role of conciliator, communicator, and cross-cultural ambassador.
Infection with the Persistent Murine Norovirus Strain MNV-S99 Suppresses IFN-Beta Release and Activation of Stat1 In Vitro
Creators: name: Niendorf, Sandra
name: Klemm, Uwe
name: Marques, Andreas Mas
name: Bock, Thomas
name: Höhne, Marina
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: 610 Medizin

description: Norovirus infection is the main cause of epidemic non-bacterial gastroenteritis in humans. Although human norovirus (HuNoV) infection is self-limiting, it can persist for extended periods of time in immune deficient patients. Due to the lack of robust cell culture and small animal systems, little is known about HuNoV pathogenicity. However, murine norovirus (MNV) can be propagated in cell culture and is used as a model to study norovirus infection. Several MNV are known to persist in mice. In this study, we show that the MNV strain MNV-S99 persists in wild type inbred (C57BL/6J) mice over a period of at least 5 weeks post infection. Viral RNA was detectable in the jejunum, ileum, cecum, and colon, with the highest titers in the colon and cecum. To characterize the effect of MNV-S99 on the innate immune response, Stat1 phosphorylation and IFN-β production were analyzed and compared to the non-persistent strain MNV-1.CW3. While MNV-S99 and MNV-1.CW3 showed comparable growth characteristics in vitro, Stat1 phosphorylation and IFN-β release is strongly decreased after infection with MNV-S99 compared to MNV-1.CW3. In conclusion, our results show that unlike MNV-1.CW3, MNV-S99 establishes a persistent infection in mice, possibly due to interfering with the innate immune response.
Soziale Determinanten der Schwimmfähigkeit von Kindern und Jugendlichen in Deutschland
Creators: name: Kuntz, Benjamin
name: Frank, Laura
name: Manz, Kristin
name: Rommel, Alexander
name: Lampert, Thomas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: gesundheitliche Ungleichheit
subject: Sozialstatus
subject: Schwimmfähigkeit
subject: Ertrinken
subject: Migrationshintergrund
subject: 610 Medizin

description: Hintergrund: Schwimmen ist eine Freizeitaktivität mit großem gesundheits- und entwicklungsförderndem Potenzial. Der Beitrag untersucht, wie hoch der Anteil der Kinder und Jugendlichen in Deutschland ist, die nicht schwimmen können, und welche Rolle Alter, Geschlecht, Sozialstatus und Migrationshintergrund dabei spielen. Methodik: In der vom Robert Koch-Institut (RKI) durchgeführten ersten Folgebefragung der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS Welle 1, 2009- 2012) wurden per Telefonsurvey Selbst- und Elternangaben zur Schwimmfähigkeit von 5- bis 17-Jährigen erhoben (n=9 750). Der Sozialstatus wird anhand von Bildung, Beruf und Einkommen der Eltern ermittelt. Der Migrationshintergrund wird über Informationen zum Geburtsland und zur Staatsangehörigkeit des Kindes und der Eltern bestimmt. Ergebnisse: 14,5% der 5- bis 17-jährigen Kinder und Jugendlichen in Deutschland können nicht schwimmen. Im Vor- und Grundschulalter liegt der entsprechende Anteil höher, im Jugendalter deutlich niedriger. Diejenigen, die schwimmen können, haben die Schwimmfähigkeit im Schnitt mit knapp 6 Jahren erlangt. Im Grundschulalter können weniger Jungen schwimmen als Mädchen, zudem lernen Mädchen rund 4 Monate früher schwimmen. Kinder und Jugendliche mit niedrigem Sozialstatus können seltener schwimmen als Gleichaltrige mit hohem Sozialstatus (OR=5,95; 95%-KI=3,74-9,47). Heranwachsende mit beidseitigem Migrationshintergrund sind häufiger Nichtschwimmer als Gleichaltrige ohne Migrationshintergrund (OR=2,39; 95%-KI=1,63-3,50). Schlussfolgerungen: Die KiGGS-Daten zeigen, dass ein erheblicher Anteil der Kinder und Jugendlichen in Deutschland nicht schwimmen kann. Initiativen zur Förderung der Schwimmfähigkeit sollten ein besonderes Augenmerk auf Heranwachsende aus sozial benachteiligten Familien und jene mit beidseitigem Migrationshintergrund richten.
On the financial connectedness of the commodity market: a replication of the Diebold and Yilmaz (2012) study
Creators: name: CALOIA, FRANCESCO GIUSEPPE
name: CIPOLLINI, Andrea
name: MUZZIOLI, Silvia
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2018

description: In this paper we replicate the Diebold and Yilmaz (2012) study on the connectedness of the Commodity market and three other financial markets: the stock market, the bond market, and the FX market. We show that both the row and the column normalization schemes of the Generalized Forecast Error Variance Decomposition, suggested by the authors, lead to inaccurate measures of net contribution to risk transmission, in terms of ranking and sign. We show that, considering data generating processes characterized by different degrees of comovement and persistence, a scalar based normalization of the Generalized Forecast Error Variance Decomposition yields consistent (free of sign and ranking errors) net spillovers.
Rating Triggers, Market Risk and the Need for More Regulation
Creators: name: PARMEGGIANI, FEDERICO
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2012

description: A rating trigger is a particular type of debt covenant that mandates the borrower to maintain its own credit rating above a certain rating threshold, requiring in the event of a rating downgrade the adoption of specific enforceable actions aimed at securing the lender claims from the borrower's higher risk level. Rating triggers lower the cost of borrowing capital, but in case they are activated they exacerbate the borrower's need for liquidity just in the moment when its credit risk is higher, making the borrower's default more likely to occur. Despite the potential threat posed by rating triggers on debt markets, these contractual devices remain almost unregulated both in the U.S. and in Europe. The purpose of this paper is first to analyze the effects rating triggers can have on overall market risk and second to assess the proliferation of rating triggers among large U.S. companies in order to ensure whether these contractual devices need a stricter regulation. The article is divided in two parts. From section 2 to 5, I provide an overview on the different types of triggers and analyze the rationale behind their use in terms of advantages and disadvantages for both issuers and investors. From section 6 to 9 I perform an empirical analysis by assessing the rating triggers that have been used by Dow Jones Industrial Average index companies. I then examine the correlation between the use of rating triggers and the companies? risk profiles by measuring their credit ratings and their Altman?s Z-Scores in order to find out whether triggers are mostly used by risky companies, capable of being impaired by the triggers? activation and thus posing a threat to market stability. Then in section 10 I draw the conclusions suggesting the introduction by U.S. and European regulators of a specific duty to disclose all the rating triggers that listed companies include every year in bond indentures and in financial contracts.
Policy Playbook for co-creation of educational practices
Creators: name: Lessner Listiakova, Ivana
name: Ruiter, Keith
name: Atenas, Javiera
name: Lessner Listiakova, Ivana
name: Atenas, Javiera
name: Betts, Emily
name: Dacosta, Chrissie
name: Grey, Robert
name: Gul, Faraz
name: Hickey, Alexander
name: Navan, Nafiseh
name: Leader, Carolyn
name: Lecluyse, Wendy
name: Merry, Caitlyn
name: Nicholson, Phil
name: Patel, Avaniben
name: Pinhal, Yara
name: Riceman, Zoe
name: Rich, Omoboroji
name: Ruiter, Keith
name: Stella, Marianna
name: Trowsdale, Jo
name: Wallace, Kevin
Publisher: name: University of Suffolk
Year: 2024
Subjects: subject: co-creation
subject: educational practices
subject: Educational sciences
subject: FOS: Educational sciences
subject: educational innovation
subject: learning co-creation
subject: educational policy
subject: higher education
subject: students engagement

description: What is this playbook?

Similar to playbooks leading players in a game, a policy playbook flexibly guides stakeholders in different contexts, such as higher education. A policy playbook offers guidance in policy development and encourages their own interpretations for their specific contexts. It lets policy developers “play” and experiment with ways of creating and implementing policies.

It empowers policy makers to involve representative voices of all stakeholders in their organisations to be involved in different ways at different stages of the policy-making process. A playbook is a resource full of creative ideas how to engage stakeholders and navigate the process of policy development. Collaboration happens at each stage with stakeholders contributing to and taking ownership of the policy, which enables them to achieve positive change in their organisation.
Development of Non-Amorphous Solid Dispersions for Poorly-Soluble Drugs Using a Novel Excipient and Hot Melt Extrusion
Creators: name: Ong, Hwee Jing
Publisher: name: Purdue University Graduate School
Year: 2020

description: Drug solubility is a persistent challenge in pharmaceutical product development. The objective of this research is to develop a formulation/processing strategy by means of a biodendrimeric solid dispersion (BDSD) platform, for increasing the solubility and dissolution rate of poorly water-soluble drugs. The BSDS platform combines a novel type of excipient, referred to as DLB, with a new application of the hot melt extrusion (HME) process.
Four model compounds – phenytoin (PHT), griseofulvin (GSF), ibuprofen (IBU), and loratadine (LOR) – were used to evaluate the solubilization effect of an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB). Shake-flask solubility measurements show that OS-DLB exerts significant solubilizing effect when present at less than 0.2% in water. The presence of hydrophobic C8 chains on OS-DLB creates the type of favorable nonpolar microenvironment necessary for producing a parallel liquid phase equilibrium responsible for the increase in the total amount of drug dissolved in aqueous media. The higher the hydrophobicity of the drug, the higher the observed solubilization effect. Isothermal titration calorimetry studies show that drug solubilization by OS-DLB occurs by means of entropy-driven interactions. These studies also show that the intermolecular interaction between IBU and OS-DLB in solution exhibits very small energy change upon mixing but a stronger effect on entropy. In comparison, the intermolecular interaction between the less hydrophobic GSF and OS-DLB have significant effects on both enthalpy and entropy. Consequently, in terms of solubilization enhancement, it was found that the interaction between IBU and OS-DLB is entropy-driven (more favorable), while in the case of GSF, the interacting molecules are arranged to maximize enthalpic interaction.
Based on the solubility studies, a formulation/processing approach for enhancing the dissolution rate of the model drugs was developed. The biopolymer serving as both carrier and solubilizing agent, was coprocessed with poloxamer, functioning as a processing aid, using hot melt extrusion (HME) as an enabling technology. The result is a non-amorphous solid dispersion, exhibiting high and long-lasting supersaturation upon dissolution. A 3-factor, 3-level Box-Behnken design was implemented to define the optimal design space for the formulation/extrusion process. The results obtained from multivariate data analysis (partial least squares and principal components analysis) and response surface modeling suggest that drug release performance of IBU BDSDs is strongly influenced by the processing variables, while maximum release of GSF from the BDSDs can be attained through selective combination of functional excipients.
Additional file 1 of An unexplored equity factor: differential beliefs and attitudes toward contingency management by providers’ ethnicity
Creators: name: Oluwoye, Oladunni
name: Weeks, Douglas L.
name: McDonell, Michael G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: Supplementary Material 1
Estimation of influenza-attributable medically attended acute respiratory illness by influenza type/subtype and age, Germany, 2001/02–2014/15
Creators: name: Heiden, Matthias An Der
name: Buchholz, Udo
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Background: The total burden of influenza in primary care is difficult to assess. The case definition of medically attended “acute respiratory infection” (MAARI) in the German physician sentinel is sensitive; however, it requires modelling techniques to derive estimates of disease attributable to influenza. We aimed to examine the impact of type/subtype and age. Methods: Data on MAARI and virological results of respiratory samples (virological sentinel) were available from 2001/02 until 2014/15. We constructed a generalized additive regression model for the periodic baseline and the secular trend. The weekly number of influenza-positive samples represented influenza activity. In a second step, we distributed the estimated influenza-attributable MAARI (iMAARI) according to the distribution of types/subtypes in the virological sentinel. Results: Season-specific iMAARI ranged from 0.7% to 8.9% of the population. Seasons with the strongest impact were dominated by A(H3), and iMAARI attack rate of the pandemic 2009 (A(H1)pdm09) was 4.9%. Regularly the two child age groups (0-4 and 5-14 years old) had the highest iMAARI attack rates reaching frequently levels up to 15%-20%. Influenza B affected the age group of 5- to 14-year-old children substantially more than any other age group. Sensitivity analyses demonstrated both comparability and stability of the model. Conclusion: We constructed a model that is well suited to estimate the substantial impact of influenza on the primary care sector. A(H3) causes overall the greatest number of iMAARI, and influenza B has the greatest impact on school-age children. The model may incorporate time series of other pathogens as they become available.
Gesundheitskompetenz von Erwachsenen in Deutschland
Creators: name: Jordan, Susanne
name: Hoebel, Jens
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2015
Subjects: subject: Gesundheitsverhalten
subject: Gesundheitskompetenz
subject: Gesundheitsstatus
subject: Allgemeine Bevölkerung
subject: Querschnittsstudie
subject: 610 Medizin

description: Hintergrund: In modernen Informationsgesellschaften wird Gesundheitskompetenz (GK) als wichtige Fähigkeit zur Gesunderhaltung und Krankheitsbewältigung erachtet. Hierfür sind verschiedene kognitive und soziale Fähigkeiten für den Umgang mit Gesundheitsinformationen grundlegend. Ziel der Arbeit: Ziele der Studie sind die Beschreibung der Verteilung von GK in der Erwachsenenbevölkerung Deutschlands und die Ermittlung von Assoziationen der GK mit Gesundheitsverhalten und -zustand. Material und Methoden: Die Analysen basieren auf Daten der Studie „Gesundheit in Deutschland aktuell“ (GEDA), einer Querschnittsbefragung der deutschsprachigen Wohnbevölkerung ab 18 Jahren, die von Oktober 2013 bis Juni 2014 durchgeführt wurde. Die GK wurde mit der Kurzform des European Health Literacy Questionnaire (HLS-EU-Q16) erhoben, zusammen mit Fragen zur Soziodemografie, zum Gesundheitsverhalten und -zustand. Für 4845 Befragte konnte der HLS-EU-Q16-Index berechnet werden. Ergebnisse: Mehr als die Hälfte der Erwachsenen hat nach den Kriterien des HLS-EU-Q16 eine „ausreichende“ GK (55,8 %). Für fast jede dritte Person ist eine „problematische“ (31,9 %) und für nahezu jede achte Person eine „inadäquate“ GK (12,3 %) zu verzeichnen. Es wurden signifikante Unterschiede bezüglich Bildung, aber nicht für Geschlecht und Alter gefunden. Bestimmte Gesundheitsverhalten waren positiv mit Gesundheitskompetenz assoziiert. Ein niedriger GK-Level ging mit einer schlechteren körperlichen sowie psychischen Gesundheit einher. Diskussion: Die Ergebnisse weisen auf Handlungsbedarf zur Verbesserung der GK in der Erwachsenenbevölkerung hin. Die Stärkung von GK sollte dabei nicht allein auf die Förderung individueller Fähigkeiten abzielen, sondern auch der Entwicklung von gesundheitskompetenten Lebenswelten einen hohen Stellenwert beimessen.
"The Sense of That Crush I feel at Certain Times, Even Now": Jacob Stroyer and the Defense of Fort Sumter
Creators: name: Ashton, Susanna Margaret
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: American Civil War (United States
subject: Slave narratives

description: In the summer of 1864, fourteen-year-old Jacob Stroyer was sent to work in Fort Sumter. He did not go willingly. Stroyer was a slave owned by the wealthy Mrs. Matthew R. Singleton and was sent from the large Kensington plantation outside Columbia, SC to labor for the Confederate cause. The Confederate Corps of Engineers called upon slave owners to contribute their enslaved people’s labor to the problem of construction and fortification of roads, bridges, and key defensive site. Stroyer explained that the fifteen slaves from his plantations “were sent to work on fortifications each year during the war.” . . .
Strumenti per il sostegno finanziario di famiglie e microimprese: il caso italiano (Policies to help financially vulnerable Italian households and micro-businesses)
Creators: name: COTTERLI, Simonetta
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2016

description: Scopo del contributo � individuare alcuni interventi normativi in ambito finanziario, indirizzati verso famiglie e micro-imprese, gi� sperimentati o auspicabili, utili ad affrontare le conseguenze della crisi economica. A tal fine si � ritenuto di prendere in considerazione gli effetti della crisi su famiglie e micro-imprese relativi a due aree, distinte ma complementari. Da una parte si � assistito infatti ad un aumento delle situazioni di deterioramento degli indebitamenti e, dall'altro, si � osservata una contrazione dell?offerta di credito. A partire da questi presupposti, sono presi in considerazione gli interventi, gi� posti in essere o che si intende suggerire, volti a favorire l?accesso al credito per famiglie e micro imprese, anche alla luce dell?opportunit� di sostenere la domanda di auto-imprenditorialit�, scaturita dalle minori prospettive di lavoro dipendente. Successivamente, sono analizzati gli strumenti per la gestione di situazioni di sovraindebitamento di persone e micro imprese, con alcune considerazioni critiche in relazione alla effettiva capacit� dimostrata, ma altres� individuandone, in prospettiva, i possibili effetti positivi. Infine si pone il quesito se, alla luce della nuova disciplina in materia di credito responsabile sia ipotizzabile la configurazione di un diritto al credito
Validation of a Method for the Assessment of Urinary Neopterin Levels to Monitor Health Status in Non-human-primate Species
Creators: name: Behringer, Verena
name: Stevens, Jeroen M. G.
name: Leendertz, Fabian H.
name: Hohmann, Gottfried
name: Deschner, Tobias
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: 610 Medizin

description: Determining individual health status is of great importance for a better understanding of life history trade-offs between growth, reproduction, and maintenance. However, existing immunological methods are invasive and therefore not suitable for investigating health status in wild populations. Thus, there is an urgent need for non-invasive methods to assess the immune status of animals. Neopterin is involved in the cell-mediated pathway of the immune response (Th1–type), secreted during the activation of monocytes and macrophages. We investigated if urinary neopterin could serve as a biomarker of health status in bonobos and chimpanzees. First, we performed a chemical validation of a commercial neopterin enzyme immune assay (EIA) for bonobo and chimpanzee urine. We then examined if urinary neopterin levels in bonobos increase during the acute period of respiratory infections. We found that neopterin levels can be reliably measured in urine of the two species with a commercial EIA. Stability experiments revealed considerable changes in urinary neopterin levels in relation to multiple freeze–thaw cycles and extended exposure to room temperature. Exposure to sunlight led to a degradation of urinary neopterin, whereas sample storage up to 2 years did not affect urinary neopterin levels. There was no detectable diurnal variation in neopterin levels, and levels remained very stable across several days in healthy individuals. While urinary neopterin levels were independent of sex, non-adult individuals had higher urinary neopterin levels than adults. Most importantly, there was a significant increase in urinary neopterin levels during a period of respiratory infection. Our results demonstrate that regular urine sample collection would allow for the monitoring of individual health status and disease progression with minimal disturbance of the subjects. In combination with behavioral, life history, and endocrinological parameters, the method can be used to investigate questions related to immunocompetence handicaps or life history trade-offs.
Additional file 1 of Health literacy in the context of child health promotion: a scoping review of conceptualizations and descriptions
Creators: name: Van Boxtel, Wieke
name: Jerković-Ćosić, Katarina
name: Schoonmade, Linda J.
name: Chinapaw, Mai J. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1: Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist
sj-pdf-1-qhr-10.1177_10497323211023449 – Supplemental material for Successfully Negotiating Life Challenges: Learnings From Adults With Cerebral Palsy
Creators: name: Gaskin, Cadeyrn J.
name: Imms, Christine
name: R. Dagley, Gavin
name: Msall, Michael E.
name: Reddihough, Dinah
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-qhr-10.1177_10497323211023449 for Successfully Negotiating Life Challenges: Learnings From Adults With Cerebral Palsy by Cadeyrn J. Gaskin, Christine Imms, Gavin R. Dagley, Michael E. Msall and Dinah Reddihough in Qualitative Health Research
Evaluation einer ICD-10-basierten elektronischen Surveillance akuter respiratorischer Erkrankungen (SEEDARE) in Deutschland
Creators: name: Köpke, Karla
name: Prahm, Kerstin
name: Buda, Silke
name: Haas, Walter
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: Influenza
subject: Epidemiologische Surveillance
subject: Datenerhebung
subject: ICD-10
subject: Elektronische Patientenakte
subject: 610 Medizin

description: Hintergrund: Influenza und andere akute respiratorische Erkrankungen (ARE) treten jährlich mit einer stark variablen Krankheitslast in epidemischen Wellen in der Bevölkerung auf. Dies erfordert eine zeitnahe syndromische Surveillance zur Beurteilung der Situation und Anpassung von Präventionsmaßnahmen. Ziel: Wir haben ein ICD-10-basiertes elektronisches System zur zeitnahen Erfassung und Übermittlung von ARE in Deutschland in Sentinelpraxen etabliert (SEEDARE). In der vorliegenden Arbeit evaluieren wir dieses neue System anhand von Ergebnissen der syndromischen und virologischen Surveillance der Arbeitsgemeinschaft Influenza (AGI). Methoden: Praxiskontakte und übermittelte ICD-10-Diagnosecodes (J00–J22, J44.0 und B34.9) zwischen der 16. Kalenderwoche (KW) 2009 und der 15. KW 2013 wurden für den Vergleich mit den Daten der AGI genutzt. Hierzu wurden der zeitliche Verlauf, die Korrelation der wöchentlich geschätzten Konsultationsinzidenz und die Anzahl ARE/100-Praxiskontakte aus den verschiedenen Systemen untersucht. Ergebnisse: Die Anzahl der teilnehmenden Arztpraxen an SEEDARE konnte von 2009 (n = 65) bis 2013 (n = 111) fast verdoppelt werden. Insgesamt wurden fast 6,8 Mio. Praxiskontakte und 465.006 ARE übermittelt. Der Vergleich der wöchentlich geschätzten Konsultationsinzidenzen zeigte eine hohe statistische Korrelation (Spearman-Korrelationskoeffizient rs = 0,924; n = 209; p < 0,001). Die Anteile von Influenzapatienten (J09–J11) und der wöchentlichen Positivenraten der virologischen Surveillance während der Influenzawellen waren ebenfalls hoch korreliert. Diskussion: Das SEEDARE-System stellt damit ein valides Instrument zur syndromischen Influenzasurveillance dar. Der fallbasierte Ansatz mittels ICD-10 erlaubt eine detaillierte Analyse der aktuellen Situation, der sich auch für populationsbasierte Studien eignet.
Additional file 2 of Health literacy in the context of child health promotion: a scoping review of conceptualizations and descriptions
Creators: name: Van Boxtel, Wieke
name: Jerković-Ćosić, Katarina
name: Schoonmade, Linda J.
name: Chinapaw, Mai J. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 2: Standards for Reporting Qualitative Research (SRQR)
Nickel Catalyzed Cycloaddition Reactions: Alkyne Cyclotrimerizations and Reductive Vinylidene Transfer Reactions
Creators: name: Pal, Sudipta
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Organic chemistry not elsewhere classified

description: The advent of transition metal catalysis has greatly expanded the scope of viable cycloaddition reactions, allowing for the direct synthesis of highly functionalized and complex biologically active compounds. By manipulating various aspects of catalyst structure, including the supporting ligands and the central metal, the function of a catalyst can be modified. In this context, the catalytic properties of dinuclear complexes have not been greatly explored in cycloaddition reactions. Our research has focused on studying the catalytic properties of dinuclear complexes in cycloaddition reactions. Comparative studies between dinuclear and mononuclear Ni-complexes led us to discover and develop an efficient route to synthesize 1,2,4-trisubstituted benzene derivatives from terminal alkynes. The key organometallic intermediates in this process were isolated, and computational studies were performed to unravel a novel bimetallic mechanism for alkyne cyclotrimerizations. As an extension of this study, we have found that the dinuclear catalyst is capable of catalyzing the methylenecyclopropanation of olefins. The reaction uses 1,1-dichloroalkene as a vinylidene precursor along with Zn as a stoichiometric reductant. A wide range of monosubstituted terminal alkenes and relatively unhindered internal alkenes are viable substrates. Furthermore, to understand the mechanism of vinylidene transfer, various stoichiometric and stereochemical experiments were performed. Furthermore, we discovered that mononuclear and dinuclear Ni-complexes are highly efficient in achieving vinylidene insertions into Si–H bonds to synthesize Si-containing heterocyclic molecules. Ongoing efforts are directed toward optimizing the reaction conditions and elucidating the substrate scope of the reaction.
sj-pdf-1-inq-10.1177_00469580211028180 – Supplemental material for Charity Care and Community Benefit in Non-Profit Hospitals: Definition and Requirements
Creators: name: Zare, Hossein
name: Eisenberg, Matthew
name: Anderson, Gerard
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-inq-10.1177_00469580211028180 for Charity Care and Community Benefit in Non-Profit Hospitals: Definition and Requirements by Hossein Zare, Matthew Eisenberg and Gerard Anderson in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
Additional file 3 of Health literacy in the context of child health promotion: a scoping review of conceptualizations and descriptions
Creators: name: Van Boxtel, Wieke
name: Jerković-Ćosić, Katarina
name: Schoonmade, Linda J.
name: Chinapaw, Mai J. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 3: Glossary
sj-pdf-1-taj-10.1177_20406223211028776 – Supplemental material for Improved clinical outcomes of tocilizumab versus cyclophosphamide for IgG4-related disease: insights from a prospective IgG4-related disease registry
Creators: name: Zongfei, Ji
name: Lijuan, Zhang
name: Ying, Sun
name: Dongmei, Liu
name: Sifan, Wu
name: Xiufang, Kong
name: Lingying, Ma
name: Yun, Liu
name: Lili, Ma
name: Huiyong, Chen
name: Lindi, Jiang
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-1-taj-10.1177_20406223211028776 for Improved clinical outcomes of tocilizumab versus cyclophosphamide for IgG4-related disease: insights from a prospective IgG4-related disease registry by Ji Zongfei, Zhang Lijuan, Sun Ying, Liu Dongmei, Wu Sifan, Kong Xiufang, Ma Lingying, Liu Yun, Ma Lili, Chen Huiyong and Jiang Lindi in Therapeutic Advances in Chronic Disease
sj-doc-1-tab-10.1177_1759720X211024025 – Supplemental material for Efficacy and safety of celecoxib combined with JOINS in the treatment of degenerative knee osteoarthritis: study protocol of a randomized controlled trial
Creators: name: Kim, Man Soo
name: Koh, In Jun
name: Sung, Yong Gyu
name: Park, Dong Chul
name: Yang, Sung Cheol
name: In, Yong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-doc-1-tab-10.1177_1759720X211024025 for Efficacy and safety of celecoxib combined with JOINS in the treatment of degenerative knee osteoarthritis: study protocol of a randomized controlled trial by Man Soo Kim, In Jun Koh, Yong Gyu Sung, Dong Chul Park, Sung Cheol Yang and Yong In in Therapeutic Advances in Musculoskeletal Disease
CHARACTERIZATION, MODELING AND DESIGN OF ULTRA-THIN VAPOR CHAMBER HEAT SPREADERS UNDER STEADY-STATE AND TRANSIENT CONDITIONS
Creators: name: Patankar, Gaurav
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: This dissertation is focused on studying transport behavior in vapor chambers at ultra-thin form factors so that their use as heat spreaders can be extended to applications with extreme space constraints. Both the steady-state and transient thermal transport behaviors of vapor chambers are studied. The steady-state section presents an experimental characterization technique, methodologies for the design of the vapor chamber wick structure, and a working fluid selection procedure. The transient section develops a low-cost, 3D, transient semi-analytical transport model, which is used to explore the transient thermal behavior of thin vapor chambers: 1) The key mechanisms governing the transient behavior are identified and experimentally validated; 2) the transient performance of a vapor chamber relative to a copper heat spreader of the same external dimensions is explored and key performance thresholds are identified; and 3) practices are developed for the design of vapor chambers under transient conditions. These analyses have been tailored to ultra-thin vapor chamber geometries, focusing on the application of heat spreading in mobile electronic devices. Compared to the conventional scenarios of use for vapor chambers, this application is uniquely characterized by compact spaces, low and transient heat input, and heat rejection via natural convection.
Chronic stress among adults in Germany
Creators: name: Hapke, Ulfert
name: Maske, Ulrike
name: Scheidt-Nave, Christa
name: Bode, Liv
name: Schlack, Robert
name: Busch, Markus
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: Health survey
subject: Depression
subject: Sleep disturbances
subject: Stress burden
subject: Burnout syndrome
subject: 610 Medizin

description: The German Health Interview and Examination Survey for Adults (DEGS1) was conducted from 2008–2011 and comprised interviews, examinations and tests. The target population was the resident population of Germany aged 18–79 years. A total of 8,152 persons participated. Chronic stress was assessed to examine its effects on health and mental wellbeing. The Screening Scale of the Trier Inventory for the Assessment of Chronic Stress was used to assess stress burden among participants up to the age of 64 years (N=5,850). High levels of stress are significantly more often reported by women (13.9%) than by men (8.2%). The prevalence of high stress levels decreases with a higher socioeconomic status (SES); it falls from 17.3% with low SES to 7.6% with high SES. High chronic stress levels are particularly common (26.2%) in persons who report low levels of social support. Depressive symptoms, burnout syndrome and sleep disturbances are more common in people who have high levels of chronic stress than in those without high levels of stress. The results confirm the importance of chronic stress as a health risk and underline the public health relevance of chronic stress.
Additional file 4 of Health literacy in the context of child health promotion: a scoping review of conceptualizations and descriptions
Creators: name: Van Boxtel, Wieke
name: Jerković-Ćosić, Katarina
name: Schoonmade, Linda J.
name: Chinapaw, Mai J. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 4: Search strategies
Erkrankungen an Paratyphus in Deutschland
Creators: name: Schöneberg, Irene
Publisher: name: Robert Koch-Institut
Year: 2000
Subjects: subject: Ausbruch
subject: Salmonella Paratyphi
subject: Zahl der Fälle
subject: Import von Fällen
subject: Laboruntersuchungen
subject: 610 Medizin

description: Die Anzahl der Erkrankungen an Paratyphus in Deutschland hat sich in den letzten Jahren – im Vergleich zu früher – verringert. In den Vorjahren (seit 1997) wurden in jedem Jahr ca. 60 Erkrankungen gemeldet, die zu einem großen Teil aus anderen Ländern importiert wurden. Im Sommer 1999 erhöhte sich die Zahl der erfassten Erkrankungen durch einen Ausbruch von Paratyphus B nach Türkeireisen. In neun verschiedenen Ländern Europas kam es zu insgesamt mehr als 300 Erkrankungen an Paratyphus B. In Deutschland wurden in diesem Zusammenhang 40 Erkrankungsfälle registriert. Die Laboruntersuchungen ergaben, dass alle untersuchten Paratyphus B-Stämme den Lysotyp Taunton/B 7 aufwiesen.
sj-pdf-1-lal-10.1177_0963947020983202 – Supplemental Material for Do worlds have (fourth) walls? A Text World Theory approach to direct address in Fleabag
Creators: name: Gibbons, Alison
name: Whiteley, Sara
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200399 Language Studies not elsewhere classified
subject: FOS: Languages and literature

description: Supplemental Material, sj-pdf-1-lal-10.1177_0963947020983202 for Do worlds have (fourth) walls? A Text World Theory approach to direct address in Fleabag by Alison Gibbons and Sara Whiteley in Journal of Language and Literature
LPS Structure and PhoQ Activity Are Important for Salmonella Typhimurium Virulence in the Gallleria mellonella Infection Model
Creators: name: Bender, Jennifer K.
name: Wille, Thorsten
name: Blank, Kathrin
name: Lange, Anna
name: Gerlach, Roman
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Animals
subject: Humans
subject: Gene Deletion
subject: Virulence Factors/genetics
subject: Bacterial Proteins/genetics
subject: Mutation
subject: Disease Models Animal
subject: Moths/microbiology
subject: Salmonella Infections/microbiology
subject: O Antigens/chemistry
subject: O Antigens/genetics
subject: Salmonella typhimurium/chemistry
subject: Salmonella typhimurium/genetics
subject: Salmonella typhimurium/growth & development
subject: Salmonella typhimurium/pathogenicity
subject: Virulence Factors/chemistry
subject: 610 Medizin

description: The larvae of the wax moth, Galleria mellonella, have been used experimentally to host a range of bacterial and fungal pathogens. In this study we evaluated the suitability of G. mellonella as an alternative animal model of Salmonella infection. Using a range of inoculum doses we established that the LD50 of Salmonella Typhimurium strain NCTC 12023 was 3.6 × 103 bacteria per larva. Further, a set of isogenic mutant strains depleted of known virulence factors was tested to identify determinants essential for S. Typhimurium pathogenesis. Mutants depleted of one or both of the type III secretion systems encoded by Salmonella Pathogenicity Islands 1 and 2 showed no virulence defect. In contrast, we observed reduced pathogenic potential of a phoQ mutant indicating an important role for the PhoPQ two-component signal transduction system. Lipopolysaccharide (LPS) structure was also shown to influence Salmonella virulence in G. mellonella. A waaL (rfaL) mutant, which lacks the entire O-antigen (OAg), was virtually avirulent, while a wzzST/wzzfepE double mutant expressing only a very short OAg was highly attenuated for virulence. Furthermore, shortly after infection both LPS mutant strains showed decreased replication when compared to the wild type in a flow cytometry-based competitive index assay. In this study we successfully established a G. mellonella model of S. Typhimurium infection. By identifying PhoQ and LPS OAg length as key determinants of virulence in the wax moth larvae we proved that there is an overlap between this and other animal model systems, thus confirming that the G. mellonella infection model is suitable for assessing aspects of Salmonella virulence function.
ESBL-Bildner als Infektionserreger beim Menschen und die Frage nach dem zoonotischen Reservoir
Creators: name: Pfeifer, Yvonne
name: Eller, Christoph
name: Leistner, Rasmus
name: Valenza, Giuseppe
name: Nickel, Silke
name: Guerra, Beatriz
name: Fischer, Jennie
name: Werner, Guido
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Antibiotikaresistenz
subject: ESBL
subject: CTX-M
subject: Escherichia coli
subject: Antimicrobial resistance
subject: 610 Medizin

description: Beta-Laktam-Antibiotika hydrolysierende Enzyme (Beta-Laktamasen) sind die Hauptursache der Resistenz gegenüber Penicillinen, Cephalosporinen und Carbapenemen bei Enterobacteriaceae. In den letzten zehn Jahren wurde eine besorgniserregende Zunahme der Resistenz gegenüber Cephalosporinen der 3. und 4. Generation beobachtet, deren Hintergrund zumeist die Bildung der „extended-spectrum betalactamases“ (ESBL) ist. Die Lokalisation der ESBL-Gene auf Plasmiden ermöglicht die schnelle Weiterverbreitung der Resistenz sowohl innerhalb einer Spezies als auch zwischen den verschiedenen gramnegativen Spezies. ESBL-bildende Bakterien findet man nicht nur bei Patienten im Krankenhaus sondern auch als Besiedler der menschlichen und tierischen Darmflora sowie in der Umwelt. Molekulare Untersuchungen von ESBL-Isolaten zeigen, dass in Deutschland bestimmte ESBL-Typen, wie die CTX-M-Enzyme, überproportional häufig vorkommen. Die Mehrheit der Escherichia coli- und Klebsiella pneumoniae-Isolate vom Menschen bilden die Enzymvarianten CTX-M-15 und CTX-M-1, während bei Nutztieren die Variante CTX-M-1 dominiert. Der detaillierte Vergleich von ESBL-bildenden Bakterien und ESBL-Plasmiden aus Mensch, Tier und Nahrungsmittel im Rahmen des RESET-Forschungsverbundes Deutschland (www.reset-verbund.de) soll die genauen Verbreitungswege und Reservoire untersuchen und bewerten.
description: Beta-lactam hydrolysing enzymes (betalactamases) are the main cause of resistance to penicillins, cephalosporins and cabapenems in Enterobacteriaceae. In the past ten years a dramatic increase of resistance to 3rd/4th generation cephalosporins was observed due to production of various extended-spectrum beta-lactamases (ESBL). The ESBL genes are often localised on conjugative plasmids facilitating the fast dissemination of resistance within a species and between different gramnegative bacteria. ESBL-producers can be found in hospitalised patients, they can colonise the gut of humans and animals, and they can be found in the environment. Molecular analyses of ESBL-producing isolates showed that CTX-M-type enzymes are the most common ESBL in Germany. The majority of Escherichia coli and Klebsiella pneumoniae isolates from human patients produce ESBL-types CTX-M-15 and CTXM- 1, whereas in livestock the ESBL-type CTX-M-1 is predominant. Currently, the German research consortium RESET performs in-depth comparisons of ESBL-producing bacteria and ESBL-gene carrying plasmids from humans, animals and food to analyse and evaluate possible transmission routes and reservoirs.
Selbstberichteter allgemeiner Gesundheitszustand nach Beruf und Alter in der Erwerbsbevölkerung
Creators: name: Burr, H.
name: Kersten, N.
name: Kroll, Lars Eric
name: Hasselhorn, H. M.
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: Soziale Ungleichheit
subject: Beruf
subject: Alter
subject: Arbeit
subject: Subjektive Gesundheit
subject: Interaktion mit Alter
subject: Age
subject: Work
subject: Self reported health
subject: Interaction with age
subject: Occupational groups
subject: Social gradient
subject: 610 Medizin

description: Bei Berufsgruppen wurde der selbstberichtete allgemeine Gesundheitszustand unter besonderer Berücksichtigung des Alters untersucht. Hierzu wurden Daten der repräsentativen Telefonbefragungen GEDA 2009 und 2010 (N = 26.303) ausgewertet. Bei Professionen zeigte sich eine niedrige Prävalenz für einen schlechten Gesundheitszustand, hingegen fand sich bei den Beschäftigten in einfachen Diensten und – bei den Männern – in einfachen manuellen Berufen eine hohe. Bei älteren Beschäftigten war die Prävalenz für einen schlechten allgemeinen Gesundheitszustand höher als bei den jüngeren. Allerdings war der diesbezügliche Unterschied zwischen Älteren und Jüngeren bei männlichen Managern sowie bei Frauen mit qualifizierten kaufmännischen und Verwaltungsberufen signifikant schwächer als im allgemeinen Durchschnitt. Bei Männern mit qualifizierten manuellen Berufen und Frauen mit einfachen manuellen Berufen war der Unterschied zwischen Älteren und Jüngeren hingegen signifikant stärker. Die mit dem Alter steigende Gesundheitskluft zwischen den Berufsgruppen sollte mehr Beachtung finden. Zum Verständnis des Zusammenhangs zwischen Arbeit, Alter und Gesundheit sind gezielte Längsschnittstudien notwendig. Es kann irreführend sein, Untersuchungen der Zusammenhänge von Arbeit und Gesundheit für das Alter zu adjustieren, da das Alter diese Beziehung moderieren kann.
description: In ocupations, self-rated general health status was examined under special consideration of age. Data from the GEDA 2009 and 2010 surveys (N = 26,303) were analyzed. Professionals had a low prevalence of poor health, whereas unskilled service workers and—among males—unskilled manual workers had a high prevalence. In older workers the prevalence of poor general health was greater than among younger workers. However, the difference in health between young and old was significantly smaller than the general pattern among male managers and women in skilled commercial and administrative occupations. Among male skilled workers and female unskilled manual workers, the difference in health between young and old was greater. The—with increasing age—growing health gap between occupational groups should receive more attention. In order to understand the relationship between work, age and health, targeted longitudinal sectional studies are needed. It might be misleading to adjust associations between work and health by age, because age might moderate this relationship.
Additional file 1 of Trajectories and correlates of mental health among urban, school-age children during the COVID-19 pandemic: a longitudinal study
Creators: name: Oblath, Rachel
name: Dayal, Rohan
name: Loubeau, J. Krystel
name: Lejeune, Julia
name: Sikov, Jennifer
name: Savage, Meera
name: Posse, Catalina
name: Jain, Sonal
name: Zolli, Nicole
name: Baul, Tithi D.
name: Ladino, Valeria
name: Ji, Chelsea
name: Kabrt, Jessica
name: Sidky, Lillian
name: Rabin, Megan
name: Kim, Do Yoon
name: Kobayashi, Imme
name: Murphy, J. Michael
name: Garg, Arvin
name: Spencer, Andrea E.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health
subject: Computational Biology

description: Additional file 1: Figure S1. Model Selection: PSC-17 Total Problems Score over Time. Table S1. Linear Mixed Models: The Relationship between Time and PSC-17 Total Problems Score. Table S2. Linear Mixed Models: The Relationship between Time, Social Risks, and School Modality with PSC-17 Total Problems Score. Table S3. Final Model: The Relationship between Time, Social Risks (measured with THRIVE), School Modality, and Sociodemographics with Mental Health Symptoms (measured with the PSC-17 Total Problems Score).