cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Male-Specific Lethal Mutations of DROSOPHILA MELANOGASTER
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1980

description: A total of 7,416 ethyl methanesulfonate (EMS)-treated second chromosomes and 6,212 EMS-treated third chromosomes were screened for sex-specific lethals. Four new recessive male-specific lethal mutations were recovered. When in homozygous condition, each of these mutations kills males during the late larval or early pupal stages, but has no detectable effect in females. One mutant, mlets, is a temperature sensitive allele of maleless, mle (Fukunaga, Tanaka and Oishi 1975), while the other three mutants identify two new loci: male-specific lethal-1 (msl-1) (two alleles) at map position 2-53.3 and male-specific lethal-2 (msl-2) at 2-9.0.——The male-specific lethality associated with these mutants is not related to the sex per se of the mutant flies, since sex-transforming genes fail to interact with these mutations. Moreover, the presence or absence of a Y chromosome in males or females has no influence on the male-specific lethal action of these mutations. Finally, no single region of the X chromosome, when present as a duplication, is sufficient to rescue males from the lethal effects of msl-1 or msl-2. These results suggest that the number of complete X chromosomes determines whether a fly homozygous for a male-specific lethal mutation lives or dies.
Tekniker: Tribological characterisation through semantic technologies
Creators: name: Casla, Patricia
Publisher: name: Zenodo
Year: 2023
Subjects: ontology
standard
data management
global workshop
ontology commons ecosystem
FAIR

description: This use case aims to reduce the number and size of experiments, as well as the cost and time, required to identify the behaviour under specific operation conditions by exploiting own and third party available data. Results from tribological experiments follow heterogeneous formats and data models due to a lack of standards. The proposed implementation approach provides formal and unambiguous data representation and homogeneous data access based on Semantic Technologies. The components involved are: Tribo-connector, Semantic Repository, TribOnt Ontology, Added Value Services.
Autosomal Factors with Correlated Effects on the Activities of the Glucose 6-Phosphate and 6-Phosphogluconate Dehydrogenases in DROSOPHILA MELANOGASTER
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1981

description: Isogenic lines, in which chromosomes sampled from natural populations of D. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD). The chromosome 3 effects on G6PD and 6PGD are clearly correlated; the chromosome 2 effects, which are not so great, also appear to be correlated, but the evidence in this case is not so strong. Examination of activity variation of ten other enzymes revealed that G6PD and 6PGD are not the only pair of enzymes showing a high positive correlation, but it is among the highest in both sets of lines. In addition, there was some evidence that the factor(s) affecting G6PD and 6PGD may also affect two other metabolically related enzymes, transaldolase and phosphoglucose isomerase.—Rocket immunoelectrophoresis was used to estimate specific CRM levels for three of the enzymes studied: G6PD, 6PGD and ME. This experiment shows that a large part of the activity variation is accounted for by variation in CRM level (especially for chromosome 3 lines), but there remains a significant fraction of the genetic component of activity variation that is not explained by CRM level.—These results suggest that the autosomal factors are modifiers involved in regulation of the expression of the X-linked structural genes for G6PD and 6PGD, but a role in determining part of the enzymes' primary structure cannot be excluded with the present evidence.
Regulation of Enzyme Activities in Drosophila: Genetic Variation Affecting Induction of Glucose 6-Phosphate and 6-Phosphogluconate Dehydrogenases in Larvae
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1983

description: The genetic basis of modulation by dietary sucrose of the enzyme activities glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activities in third instar larvae of Drosophila melanogaster was investigated, using isogenic lines derived from wild populations. Considerable genetically determined variation in response was detected among lines that differed only in their third chromosome constitution. Comparison of crossreacting material between a responding and a nonresponding line showed that the G6PD activity variation is due to changes in G6PD protein level. These differences in responses are localized in the fat body, with 300 m m sucrose in the diet resulting in a sixfold stimulation of G6PD activity and a fourfold one of 6PGD in the line showing the strongest response. In this tissue, the responses of the two enzymes are closely correlated with one another. Using recombinant lines, we obtained data that suggested the existence of more than one gene on chromosome III involved in the regulation of G6PD in the fat body, and at least one of these genes affects the level of 6PGD as well.
Analysis of the Dosage Compensation of a Specific Transcript in DROSOPHILA MELANOGASTER
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The amount of steady-state level RNA complementary to the X-linked salivary gland secretion polypeptide gene Sgs-4 was measured in male and female third-instar larvae carrying one or two doses of a wild-type allele of the gene. RNA levels were found to be compensated in normal one-dose males and two-dose females and to be dosage-dependent within each sex. The presence of mutant alleles of male-less (mle) was found to reduce the level of Sgs-4 transcripts in males. These results support the contentions that dosage compensation is mediated by regulating the level of X-linked gene transcripts and that a product of the mle+ gene is involved in this process.
title: Дифференциация уголовной ответственности за преступления в сфере предпринимательской деятельности
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2023

description: Монография представляет собой комплексное исследование вопросов дифференциации уголовной ответственности за преступления в сфере предпринимательской деятельности, проведённое с использованием научных достижений в области уголовного и предпринимательского права, экономики, социологии, а также обширного эмпирического материала. Автором разработана теоретическая концепция системы преступлений в сфере предпринимательской деятельности. Нормативный материал приведён по состоянию на 1 декабря 2022 года. Адресуется специалистам в области уголовной политики, уголовного права и криминологии, студентам, курсантам, слушателям, аспирантам, адъюнктам, докторантам, преподавателям высших юридических учебных заведений, сотрудникам правоохранительных органов и работникам судебной системы.
Sum of Three Cubes via Optimisation
Creators: name: Lazov, Boian
name: Vetsov, Tsvetan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: Optimization and Control (math.OC)
subject: Computation (stat.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: G.3; G.1.6; I.2.8
subject: 11D25 (Primary) 90C90 (Secondary)

description: By first solving the equation $x^3+y^3+z^3=k$ with fixed $k$ for $z$ and then considering the distance to the nearest integer function of the result, we turn the sum of three cubes problem into an optimisation one. We then apply three stochastic optimisation algorithms to this function in the case with $k=2$, where there are many known solutions. The goal is to test the effectiveness of the method in searching for integer solutions. The algorithms are a modification of particle swarm optimisation and two implementations of simulated annealing. We want to compare their effectiveness as measured by the running times of the algorithms. To this end, we model the time data by assuming two underlying probability distributions -- exponential and log-normal, and calculate some numerical characteristics for them. Finally, we evaluate the statistical distinguishability of our models with respect to the geodesic distance in the manifold with the corresponding Fisher information metric.
description: 21 pages without the appendices. Any comments will be greatly appreciated!
Frequency and Directionality of Gene Conversion Events Involving the CYC7-H3 Mutation in SACCHAROMYCES CEREVISIAE
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The CYC7-H3 mutation is a 5-kb deletion that causes overproduction of iso-2 cytochrome c. Unlike most mutations in yeast, the CYC7-H3 mutation is preferentially lost when it is involved in a gene conversion event. We have shown that cloned copies of CYC7-H3 DNA that are inserted into the yeast genome are associated with a high frequency of recombination and aberrant segregation events. Since parity in conversion frequency was observed when the extensive insertion/deletion heterozygosity at this locus was eliminated, we conclude that the CYC7-H3 sequences are inherently capable of acting as donors or recipients in gene conversion events, although they are unlikely to act as donors when they are located opposite a large heterology. DNA sequence comparisons revealed similarities between the CYC7-H3 junction region and the 2-µm circle DNA region that is involved in site-specific recombination.
On the Development of Stress State and Rate-dependent Micromechanical FE  Models for Cold-Sprayed Ceramic-Metal Composite Coatings
Creators: Sayahlatifi, Saman
Zaiemyekeh, Zahra
Shao, Chenwei
Jibran, Wania
McDonald, André
Hogan, James David
Publisher: name: University of Alberta Library
Year: 2022

Conference abstract. Part of the Proceedings of the Canadian Society for Mechanical Engineering International Congress 2022.
Molecular and Cytogenetic Characterization of a Metallothionein Gene of Drosophila
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: A chromosomal DNA segment containing the metallothionein gene was isolated from a genomic library of Drosophila melanogaster using a previously characterized cDNA of this species as a probe. A segment of 1543 base pair (bp) was sequenced and found to include the cDNA sequence interrupted by one small intron. Several lines of evidence indicate that there is a single copy of the metallothionein gene (Mtn) in Drosophila; any other related genes, if they occur, must be sufficiently different that they are not detectable by our probe, even under hybridization conditions of reduced stringency. According to in situ hybridization and deletion mapping, Mtn is located in the right arm of the third chromosome in region 85E10-15. Within 300 bases upstream of the apparent site of transcription initiation, there are several short intervals very similar to the 12-bp segments considered to be responsible for metal regulation in mammalian systems.
Longterm existence of solutions of a reaction diffusion system with non-local terms modeling an immune response -- an interpretation-orientated proof
Creators: name: Reisch, Cordula
name: Langemann, Dirk
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35A01, 35K57, 35Q92, 45K05, 92-10

description: This paper shows the global existence and boundedness of solutions of a reaction diffusion system modeling liver infections. The existence proof is presented step by step and the focus lies on the interpretation of intermediate results in the context of liver infections which is modeled. Non-local effects in the dynamics between the virus and the immune system cells coming from the immune response in the lymphs lead to an integro-partial differential equation. While existence theorems for parabolic partial differential equations are textbook examples in the field, the additional integral term requires new approaches to proving the global existence of a solution. This allows to set up an existence proof with a focus on interpretation leading to more insight in the system and in the modeling perspective at the same time. We show the boundedness of the solution in the $L^1(Ω)$- and the $L^2(Ω)$-norms, and use these results to prove the global existence and boundedness of the solution. A core element of the proof is the handling of oppositely acting mechanisms in the reaction term, which occur in all population dynamics models and which results in reaction terms with opposite monotonicity behavior. In the context of modeling liver infections, the boundedness in the $L^\infty(Ω)$-norm has practical relevance: Large immune responses lead to strong inflammations of the liver tissue. Strong inflammations negatively impact the health of an infected person and lead to grave secondary diseases. The gained rough estimates are compared with numerical tests.
description: 32 pages, 7 figures
Solution for Soilless Culture Nutrient
Creators: name: De Freitas, Edison Pignaton
Publisher: name: Zenodo
Year: 2023
Subjects: ontology
standard
data management
global workshop
ontology commons ecosystem
FAIR

description: The use case aims to semantically represent heterogeneous IoT devices using unified IIoT ontology, based on well-established ontologies, in order to mitigate interoperability problems in industrial applications (data interoperability and interconnectivity).
Reversal of a Neurospora Translocation by Crossing over Involving Displaced Rdna, and Methylation of the Rdna Segments That Result from Recombination
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: In translocation OY321 of Neurospora crassa, the nucleolus organizer is divided into two segments, a proximal portion located interstitially in one interchange chromosome, and a distal portion now located terminally on another chromosome, linkage group I. In crosses of Translocation x Translocation, exceptional progeny are recovered nonselectively in which the chromosome sequence has apparently reverted to Normal. Genetic, cytological, and molecular evidence indicates that reversion is the result of meiotic crossing over between homologous displaced rDNA repeats. Marker linkages are wild type in these exceptional progeny. They differ from wild type, however, in retaining an interstitial block of rRNA genes which can be demonstrated cytologically by the presence of a second, small interstitial nucleolus and genetically by linkage of an rDNA restriction site polymorphism to the mating-type locus in linkage group I. The interstitial rDNA is more highly methylated than the terminal rDNA. The mechanism by which methylation enzymes distinguish between interstitial rDNA and terminal rDNA is unknown. Some hypotheses are considered.
title: Профессиональный французский язык в сфере биомедицинской инженерии = Français professionnel en génie biomedical
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2023

description: Учебное пособие нацелено на подготовку студентов к работе со специальной литературой, обучение устным формам общения по научной тематике на материале предложенных текстов, системное развитие коммуникативных способностей студентов, расширение их активного и пассивного лексического и грамматического запаса. Данное пособие содержит лексикограмматический материал для профессионального и бытового общения и чтения научной литературы, способствует формированию у будущих специалистов умения работать самостоятельно (реферирование и аннотирование) с научно-популярными и научными текстами по данной тематике; формирует навыки научно-технического перевода и умение общаться на французском языке. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта высшего образования. Предназначено для студентов бакалавриата, магистратуры и аспирантуры, обучающихся по направлениям медико-технической подготовки 12.00.00 «Фотоника, приборостроение, оптические и биотехнические системы и технологии», изучающих профессиональный французский язык. Будет полезно и для специалистов, работающих с биомедицинской техникой.
Chaotic inflation in higher derivative gravity theories
Creators: name: Myrzakul, Shynaray
name: Myrzakulov, Ratbay
name: Sebastiani, Lorenzo
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we investigate chaotic inflation from scalar field subjected to potential in the framework of $f(R^2, P, Q)$-gravity, where we add a correction to Einstein's gravity based on a function of the square of the Ricci scalar $R^2$, the contraction of the Ricci tensor $P$, and the contraction of the Riemann tensor $Q$. The Gauss-Bonnet case is also discussed. We give the general formalism of inflation, deriving the slow-roll parameters, the $e$-folds number, and the spectral indexes. Several explicit examples are furnished, namely we will consider the cases of massive scalar field and scalar field with quartic potential and some power-law function of the curvature invariants under investigation in the gravitational action of the theory. Viable inflation according with observations is analyzed.
description: 19 pages, final version, accepted in EPJC
Metallothionein Gene Duplications and Metal Tolerance in Natural Populations of Drosophila melanogaster
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: A search for duplications of the Drosophila melanogaster metallothionein gene (Mtn) yielded numerous examples of this type of chromosomal rearrangement. These duplications are distributed widely—we found them in samples from four continents, and they are functional—larvae carrying Mtn duplications produce more Mtn RNA and tolerate increased cadmium and copper concentrations. Six different duplication types were characterized by restriction-enzyme analyses using probes from the Mtn region. The restriction maps show that in four cases the sequences, ranging in size between 2.2 and 6.0 kb, are arranged as direct, tandem repeats; in two other cases, this basic pattern is modified by the insertion of a putative transposable element into one of the repeated units. Duplications of the D. melanogaster metallothionein gene such as those that we found in natural populations may represent early stages in the evolution of a gene family.
title: Французский язык в сфере биомедицинской техники = Le français en génie biomédical
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование, Ай Пи Ар Медиа
Year: 2023

description: Учебное пособие содержит лексикограмматический материал для профессионального и бытового общения и чтения научной литературы. Издание способствует формированию умения работать самостоятельно с научно-популярными и научными текстами, формирует навыки научно-технического перевода, помогает расширить активный и пассивный лексический и грамматический запаса. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Учебное пособие предназначено для студентов специальностей 12.02.06 «Биотехнические и медицинские аппараты и системы», 12.02.10 «Монтаж, техническое обслуживание и ремонт биотехнических и медицинских аппаратов и систем», 31.02.01 «Лечебное дело», 34.02.01 «Сестринское дело», изучающих дисциплину «Иностранный язык (французский)».
Production and Characterization of Radiation-Sensitive Meiotic Mutants of Coprinus Cinereus
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: We have isolated four γ-ray-sensitive mutants of the basidiomycete Coprinus cinereus. When homozygous, two of these (rad 3-1 and rad 9-1) produce fruiting bodies with very few viable basidiospores, the products of meiosis in this organism. A less radiation-sensitive allele of RAD 3, rad 3-2, causes no apparent meiotic defect in homozygous strains. Quantitative measurements of oidial survival of rad 3-1;rad 9-1 double mutants compared to the single mutants indicated that rad 3-1 and rad 9-1 mutants are defective in the same DNA repair pathway. In the few viable basidiospores that are produced by these two strains, essentially normal levels of meiotic recombination can be detected. None of the mutants exhibits increased sensitivity to UV radiation. Cytological examination of meiotic chromosomes from mutant and wild-type fruiting bodies showed that rad 3-1 homozygous strains fail to condense and pair homologous chromosomes during prophase I. Although rad 9-1 strains are successful at chromosome pairing, meiosis is usually not completed in these mutants.
High Order Elements in Finite Fields Arising from Recursive Towers
Creators: name: Dose, Valerio
name: Mercuri, Pietro
name: Pal, Ankan
name: Stirpe, Claudio
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We provide a recipe to construct towers of fields producing high order elements in $\mathrm{GF}(q,2^n)$, for odd $q$, and in $\mathrm{GF}(2,2 \cdot 3^n)$, for $n \ge 1$. These towers are obtained recursively by $x_{n}^2 + x_{n} = v(x_{n - 1})$, for odd $q$, or $x_{n}^3 + x_{n} = v(x_{n - 1})$, for $q=2$, where $v(x)$ is a polynomial of small degree over the prime field $\mathrm{GF}(q,1)$ and $x_n$ belongs to the finite field extension $\mathrm{GF}(q,2^n)$, for $q$ odd, or to $\mathrm{GF}(2,2\cdot 3^n)$. Several examples are carried out and analysed numerically. The lower bounds of the orders of the groups generated by $x_n$, or by the discriminant $δ_n$ of the polynomial, are similar to the ones obtained in [BCG+09], but we get better numerical results in some cases.
La Contribution des Entreprises de la Région Tanger-Tétouan-Al-Hoceima à la Résilience Régionale et au Développement Durable
Creators: name: AMARA ZENATI Ahlam
name: WAHBI Miriam
name: MAATOUK Mustapha
name: ELMOUMNI Bouchta
Publisher: name: Zenodo
Year: 2023

description: Le développement économique, social et environnemental durable est devenu un enjeu crucial dans le monde actuel. Pour atteindre cette durabilité, une approche de résilience durable est nécessaire, notamment dans les régions vulnérables aux impacts du changement climatique et connaissant une croissance rapide. Au Maroc, la région de Tanger-Tétouan-Alhoceima est dynamique économiquement, mais est également confrontée à des défis environnementaux tels que la dégradation des ressources naturelles et les risques de catastrophes naturelles liées au changement climatique. Dans ce contexte, les entreprises de la région ont un rôle crucial à jouer dans la promotion de la résilience territoriale et du développement durable. Cette étude vise donc à examiner le rôle des entreprises dans la promotion de la résilience régionale et du développement durable dans la région de Tanger-Tétouan-Alhoceima au Maroc. Pour y parvenir, cet article se concentrera sur la définition du concept de la résilience régional et son service au développement durable, sur l'examen du rôle des entreprises dans la promotion du développement durable et de la résilience territoriale, et sur l'analyse des pratiques des entreprises installées dans la région de Tanger-Tétouan-Al Hoceima. Finalement, cet article soulignera l'importance de la collaboration entre les gouvernements, les entreprises et la société civile pour promouvoir la durabilité et la résilience des régions.
Entangled bases with fixed Schmidt number
Creators: name: Guo, Yu
name: Du, Shuanping
name: Li, Xiulan
name: Wu, Shengjun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: An entangled basis with fixed Schmidt number $k$ (EBk) is a set of orthonormal basis states with the same Schmidt number $k$ in a product Hilbert space $\mathbb{C}^d\otimes\mathbb{C}^{d'}$. It is a generalization of both the product basis and the maximally entangled basis. We show here that, for any $k\leq\min\{d,d'\}$, EBk exists in $\mathbb{C}^d\otimes\mathbb{C}^{d'}$ for any $d$ and $d'$. Consequently, general methods of constructing SEBk (EBk with the same Schmidt coefficients) and EBk (but not SEBk) are proposed. Moreover, we extend the concept of EBk to multipartite case and find out that the multipartite EBk can be constructed similarly.
description: 7 pages. Minors are corrected
Sequence Analysis of N-Ethyl-N-Nitrosourea-Induced Vermilion Mutations in Drosophila Melanogaster
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: The mutational specificity of N-ethyl-N-nitrosourea (ENU) was determined in Drosophila melanogaster using the vermilion locus as a target gene. 25 mutants (16 F(1) and 9 F(2) mutants) were cloned and sequenced. Only base-pair changes were observed; three of the mutants represented double base substitutions. Transition mutations were the most prominent sequence change: 61% were GC->AT and 18% AT->GC substitutions. Both sequence changes can be explained by the miscoding properties of the modified guanine and thymine bases. A strong bias of neighboring bases on the occurrence of the GC->AT transitions or a strand preference of both types of transition mutations was not observed. The spectrum of ENU mutations in D. melanogaster includes a significant fraction (21%) of transversion mutations. Our data indicate that like in other prokaryotic and eukaryotic systems also in D. melanogaster the O(6)-ethylguanine adduct is the most prominent premutational lesion after ENU treatment. The strong contribution of the O(6)-ethylguanine adduct to the mutagenicity of ENU possibly explains the absence of distinct differences between the type of mutations observed in the F(1) and F(2) mutants. Although the latter arise later during development, the spectrum of mosaic mutations is also dominated by GC->AT transition mutations.
Selection between foreground models for global 21-cm experiments
Creators: name: Harker, Geraint
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The precise form of the foregrounds for sky-averaged measurements of the 21-cm line during and before the epoch of reionization is unknown. We suggest that the level of complexity in the foreground models used to fit global 21-cm data should be driven by the data, under a Bayesian model selection methodology. A first test of this approach is carried out by applying nested sampling to simplified models of global 21-cm data to compute the Bayesian evidence for the models. If the foregrounds are assumed to be polynomials of order n in log-log space, we can infer the necessity to use n=4 rather than n=3 with <2h of integration with limited frequency coverage, for reasonable values of the n=4 coefficient. Using a higher-order polynomial does not necessarily prevent a significant detection of the 21-cm signal. Even for n=8, we can obtain very strong evidence distinguishing a reasonable model for the signal from a null model with 128h of integration. More subtle features of the signal may, however, be lost if the foregrounds are this complex. This is demonstrated using a simpler model for the signal that only includes absorption. The results highlight some pitfalls in trying to quantify the significance of a detection from errors on the parameters of the signal alone.
description: 5 pages, 4 figures
The Genetics of the Dras3-Roughened-Ecdysoneless Chromosomal Region (62b3-4 to 62d3-4) in Drosophila Melanogaster: Analysis of Recessive Lethal Mutations
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: The genetic organization of interval 62B3-4 to 62D3-4 on the Drosophila third chromosome was investigated. The region (designated DRE) includes four known loci: Roughened (R; 3-1.4), defined by a dominant mutation disrupting eye morphology; the nonvital locus Aprt, structural gene for adenine phosphoribosyltranferase; Dras3, a homolog of the vertebrate ras oncogene; and l(3)ecdysoneless (l(3)ecd), a gene that has been implicated in the regulation of larval molting hormone (ecdysteroid) synthesis. Overlapping chromosomal deletions of the region were generated by γ-ray-induced reversion of the R mutation. Recessive lethal mutations were isolated based upon failure to complement the recessive lethality of Df(3L)R(R2), a deletion of the DRE region that removes 16-18 polytene chromosome bands. A total of 117 mutations were isolated following ethyl methanesulfonate and γ-ray mutagenesis. These and two additional mutations define 13 lethal complementation groups. Mutations at two loci were recovered at disproportionately high rates. One of these loci is preferentially sensitive to radiation-induced mutational alterations. Additionally, an unusually low recovery rate for cytologically detectable rearrangement breakpoints within the γ-ray-sensitive locus suggests that an interval of the DRE region closely linked to the R locus may be dominantly sensitive to position effects. Lethal phase analysis of mutant hemizygotes indicates that a high proportion of DRE-region loci (11 of 13) are necessary for larval development. Mutations in five loci cause predominantly first-instar larval lethality, while mutations in four other loci cause predominantly second-instar lethality. Mutations in two loci cause late-larval lethality associated with abnormal imaginal disc development. A temperature-sensitive allele of one newly identified complementation group blocks ecdysteroid-induced pupariation. This developmental block is overcome by dietary 20-hydroxyecdysone, suggesting that a second locus in the region in addition to l(3)ecd may play a role in the regulation of late larval ecdysteroid levels.
Optimizing hypergraph-based polynomials modeling job-occupancy in queueing with redundancy scheduling
Creators: name: Brosch, Daniel
name: Laurent, Monique
name: Steenkamp, Andries
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90Cxx (Primary), 90C25, 26B25 (Secondary)

description: We investigate two classes of multivariate polynomials with variables indexed by the edges of a uniform hypergraph and coefficients depending on certain patterns of union of edges. These polynomials arise naturally to model job-occupancy in some queuing problems with redundancy scheduling policy. The question, posed by Cardinaels, Borst and van Leeuwaarden (arXiv:2005.14566, 2020), is to decide whether their global minimum over the standard simplex is attained at the uniform probability distribution. By exploiting symmetry properties of these polynomials we can give a positive answer for the first class and partial results for the second one, where we in fact show a stronger convexity property of these polynomials over the simplex.
description: 39 pages, including 2 figures and 10 tables
Gravitational radiation-reaction in arbitrary dimension
Creators: name: Birnholtz, Ofek
name: Hadar, Shahar
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use effective field theory tools to study non-conservative effects in systems of gravitating objects in general spacetime dimension. Using the classical version of the Closed Time Path formalism, we treat both the radiative gravitational field and its dynamical sources within a single action principle. New results include the radiation-reaction effective action in arbitrary dimensions to leading and +1PN orders, as well as the generalized Quadrupole formula to order +1PN.
title: Intimate Partner Homicide
Creators: name: Page, Karitta A.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2007

description: Using data collected from the Chicago Women's Health Risk Study (Block 2000), this study looked at female perpetrated intimate partner homicide. The purpose of this study was to identify what factors, if any, differentiate between abused women who kill versus abused women who do not kill their intimate partners. Through conducting this study, several factors such as substance abuse, support networks and severe violence were compared between abused women who kill their intimate partner versus those who were abused women but did not kill. It was found that severe abuse, substance abuse by the abuser and the abused person were highly correlated with homicide.
D15 Activity report on progress in Trust activities across the SSH domain
Creators: name: Kvamme, Trond
name: Dolinar, Maja
name: Braukmann, Ricarda
name: Kleemola, Mari
name: Recker, Jonas
name: Alfredsson, Iris
Publisher: name: Zenodo
Year: 2022
Subjects: CESSDA
Trust
Trustworthy Digital Repository, TDR
Social Science
SSH
CoreTrustSeal
Open Science
FAIR
EOSC

description: Trust is an essential part of open science, FAIR, and the European Open Science Cloud (EOSC). This report provides an analysis of the recent developments in Trust activities, focusing on the SSH domain and Europe, that are of interest to CESSDA and its Service Providers (SPs). The report builds on the earlier Trust landscape reports, and the topics covered include repository certification, community principles, automated FAIR assessments and metrics, and other Trust-related initiatives, networks and projects within and beyond Europe. The report concludes with a set of recommendations for CESSDA and the Service Providers.
Genetic Evidence for Preferential Strand Transfer during Meiotic Recombination in Yeast
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: During meiotic recombination in the yeast Saccharomyces cerevisiae, heteroduplexes are formed as an intermediate in the exchange process. In the formation of an asymmetric heteroduplex, one chromosome acts as a donor of a single DNA strand and the other acts as a recipient. We present genetic evidence that the nontranscribed strand is donated more frequently than the transcribed strand in spores that have an unrepaired mismatch at the HIS4 locus.
Sections of Lagrangian fibrations on holomorphically symplectic manifolds and degenerate twistorial deformations
Creators: name: Bogomolov, Fedor
name: Deev, Rodion
name: Verbitsky, Misha
Publisher: name: arXiv
Year: 2020
Subjects: subject: Algebraic Geometry (math.AG)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: Let $(M,I, Ω)$ be a holomorphically symplectic manifold equipped with a holomorphic Lagrangian fibration $π:\; M \mapsto X$, and $η$ a closed form of Hodge type (1,1)+(2,0) on $X$. We prove that $Ω':=Ω+π^* η$ is again a holomorphically symplectic form, for another complex structure $I'$, which is uniquely determined by $Ω'$. The corresponding deformation of complex structures is called "degenerate twistorial deformation". The map $π$ is holomorphic with respect to this new complex structure, and $X$ and the fibers of $π$ retain the same complex structure as before. Let $s$ be a smooth section of of $π$. We prove that there exists a degenerate twistorial deformation $(M,I', Ω')$ such that $s$ is a holomorphic section.
description: 16 pages, Latex
Power-efficient production of photon pairs in a tapered chalcogenide microwire
Creators: name: Meyer-Scott, Evan
name: Dot, Audrey
name: Ahmad, Raja
name: Li, Lizhu
name: Rochette, Martin
name: Jennewein, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Using tapered fibers of As2Se3 chalcogenide glass, we produce photon pairs at telecommunication wavelengths with low pump powers. We found maximum coincidences-to-accidentals ratios of $2.13\pm0.07$ for degenerate pumping with 3.2 μW average power, and $1.33\pm0.03$ for non-degenerate pumping with 1.0 μW and 1.5 μW average power of the two pumps. Our results show that the ultrahigh nonlinearity in these microwires could allow single-photon pumping to produce photon pairs, enabling the production of large entangled states, heralding of single photons after lossy transmission, and photonic quantum information processing with nonlinear optics.
description: 5 pages, 6 figures. Updated to published version
Genetic Analysis of a Meiotic Recombination Hotspot on Chromosome III of Saccharomyces Cerevisiae
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: In a previous study, we analyzed meiotic recombination events that occurred in the 22-kb region (LEU2 to CEN3) of chromosome III of Sacchromyces cerevisiae. We found one region with an enhanced level of crossovers (a hotspot) and one region with a depressed level of crossovers. In this study, we show that about one-third of the crossovers that occur between LEU2 and CEN3 are initiated in a 1.3-kb region located approximately 6 kb from the centromere. Both crossovers and gene conversion events are initiated at this site. Events initiated at this position can be resolved as crossovers in regions located either centromere-distally or centromere-proximally from the initiation site.
A Sufficient condition for compactness of Hankel operators
Creators: name: Celik, Mehmet
name: Sahutoglu, Sonmez
name: Straube, Emil J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Complex Variables (math.CV)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47B35, 32W05

description: Let $Ω$ be a bounded convex domain in $\mathbb{C}^{n}$. We show that if $φ\in C^{1}(\overlineΩ)$ is holomorphic along analytic varieties in $bΩ$, then $H^{q}_φ$, the Hankel operator with symbol $φ$, is compact. We have shown the converse earlier, so that we obtain a characterization of compactness of these operators in terms of the behavior of the symbol relative to analytic structure in the boundary. A corollary is that Toeplitz operators with these symbols are Fredholm (of index zero).
description: 10 pages, to appear in J. Operator Theory, minor changes
On optimal $L^2$- and surface flux convergence in FEM (extended version)
Creators: name: Horger, T.
name: Melenk, J. M.
name: Wohlmuth, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We show that optimal $L^2$-convergence in the finite element method on quasi-uniform meshes can be achieved if, for some $s_0 > 1/2$, the boundary value problem has the mapping property $H^{-1+s} \rightarrow H^{1+s}$ for $s \in [0,s_0]$. The lack of full elliptic regularity in the dual problem has to be compensated by additional regularity of the exact solution. Furthermore, we analyze for a Dirichlet problem the approximation of the normal derivative on the boundary without convexity assumption on the domain. We show that (up to logarithmic factors) the optimal rate is obtained.
Molecular Analysis of the Coprinus Cinereus Mating Type a Factor Demonstrates an Unexpectedly Complex Structure
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We report here the molecular cloning of the A43 mating type factor from Coprinus cinereus, a basidiomycetous fungus. Our molecular analyses revealed an unexpected source of variation in the A factor. Though genetic studies have demonstrated that A has two subunits, α and β, we located three nonoverlapping fragments in the A43 region that have A factor function following DNA-mediated transformation. The three fragments demonstrate no similarity to one another as judged by restriction enzyme maps and by hybridization on Southern blots. We conclude that the A43 factor is composed of at least three subunits. When strains carrying different A factors are examined by hybridization to the cloned subunits, extensive polymorphism is seen. Both intensity of hybridization and restriction fragment lengths vary between strains. Some strains fail to show any hybridization to a probe. In contrast, other strains from widely separated geographic locations apparently share very similar subunits. From comparative restriction enzyme mapping of A43 and a mutated A43 factor, we inferred that a 12-kb deletion in the A factor was responsible for the constitutive, dominant phenotype of the mutated A factor. The results of transformation experiments support an activator model for the activity of the A factor in regulating the A pathway.
title: Lernen von Kanada? Perspektiven für die  deutsche Integrationspolitik
Creators: name: Wieland, Ulrike
Publisher: name: Bertelsmann Stiftung
Year: 2023
Subjects: subject: Migration
subject: Einwanderung
subject: Integration
subject: Integrationspolitik
subject: Kanada

description: Die migrationsbedingte Vielfalt in Deutschland wächst. Für die zukunftsfähige Weiterentwicklung der deutschen Einwanderungsgesellschaft blicken Politik und Zivilgesellschaft nach Kanada. Dialog und Austausch zwischen beiden Ländern bieten die Chance, Vielfalt zum Wohle aller zu gestalten und die Partnerschaft zwischen den Demokratien zu stärken. Dieser Policy Brief gibt zunächst einen knappen Überblick über Einwanderung in Kanada im historischen und aktuellen Kontext. Anschließend werden einige Charakteristika der kanadischen Integrationspolitik herausgearbeitet und anhand von Beispielen näher beschrieben. Danach wird auf gegenwärtige Herausforderungen in Kanadas multikultureller Gesellschaft eingegangen. Abschließend werden vor dem Hintergrund der kanadischen Erfahrung Perspektiven für die Integrationspolitik in Deutschland aufgezeigt.
Splicing of Retrotransposon Insertions from Transcripts of the Drosophila Melanogaster Vermilion Gene in a Revertant
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: A mutation of the Drosophila melanogaster vermilion (v) gene known as v(1) is caused by the insertion of a 412 retrotransposon into the 5' untranslated region of the first exon. Mutants carrying this insertion accumulate a low level of mRNA from which most of the transposon sequences have been eliminated by splicing at cryptic sites within transposon sequences. Here, we demonstrate that a revertant of the v(1) allele called v(+37) is caused by the insertion of a second retrotransposon, the B104/roo element, into a site near one end of the 412 element. The revertant strain accumulates a higher level of mRNA from which most of both transposons have been removed by splicing at new donor sites introduced by the B104/roo insertion and the same acceptor site within 412. Mutations at suppressor of sable [su(s)], which increase the accumulation of v(1) transcripts, slightly elevate the level of v(+37) RNA. In addition, we show that the first v intron downstream of the 412 insertion is not efficiently removed in the v(1) mutant, and suppressor and reversion mutations increase the proportion of transcripts that are properly spliced at that downstream intron. Thus, it appears that both the suppressor and reversion mutations exert an effect at the level of pre-mRNA splicing.
Towards Designing a Conversation Mining System for Customer Service Chatbots
Creators: name: Schloß, Daniel
name: Gnewuch, Ulrich
name: Mädche, Alexander
Publisher: name: AIS eLibrary (AISeL)
Year: 2022
Subjects: Chatbot
Customer service
Conversation Mining
Design Science Research

description: Chatbots are increasingly used to provide customer service. However, despite technological advances, customer service chatbots frequently reach their limits in customer interactions. This is not immediately apparent to both chatbot operators (e.g., customer service managers) and chatbot developers because analyzing conversational data is difficult and labor-intensive. To address this problem, our ongoing design science research project aims to develop a conversation mining system for the automated analysis of customer-chatbot conversations. Based on the exploration of large dataset (N= 91,678 conversations) and six interviews with industry experts, we developed the backend of the system. Specifically, we identified and operationalized important criteria for evalu-ating conversations. Our next step will be the evaluation with industry experts. Ultimately, we aim to contribute to research and practice by providing design knowledge for conversation mining systems that leverage the treasure trove of data from customer-chatbot conversations to generate valuable insights for managers and developers.
The Tn3 β-Lactamase Gene Acts as a Hotspot for Meiotic Recombination in Yeast
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Although genetic distances are often assumed to be proportional to physical distances, chromosomal regions with unusually high (hotspots) or low (coldspots) levels of meiotic recombination have been described in a number of genetic systems. In general, the DNA sequences responsible for these effects have not been determined. We report that the 5' region of the β-lactamase (amp(R)) gene of the bacterial transposon Tn3 is a hotspot for meiotic recombination when inserted into the chromosomes of the yeast Saccharomyces cerevisiae. When these sequences are homozygous, both crossing over and gene conversion are locally stimulated. The 5' end of the β-lactamase gene is about 100-fold ``hotter'' for crossovers than an average yeast DNA sequence.