Additional file 1 of Timing of interval debulking surgery and postoperative chemotherapy after neoadjuvant chemotherapy in advanced epithelial ovarian cancer: a multicenter real-world study
Creators: name: Liu, Xingyu
name: Zhao, Yingjun
name: Jiao, Xiaofei
name: Yu, Yang
name: Li, Ruyuan
name: Zeng, Shaoqing
name: Chi, Jianhua
name: Ma, Guanchen
name: Huo, Yabing
name: Li, Ming
name: Peng, Zikun
name: Liu, Jiahao
name: Zhou, Qi
name: Zou, Dongling
name: Wang, Li
name: Li, Qingshui
name: Wang, Jing
name: Yao, Shuzhong
name: Chen, Youguo
name: Ma, Ding
name: Hu, Ting
name: Gao, Qinglei
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Supplementary Table S1. List of Study Sites. Supplementary table S2. Clinical characteristics of patients according to TTS. Abbreviation: IQR, Interquartile range; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; CA125, Cancer antigen 125; NACT, Neoadjuvant chemotherapy; Total cycles, the total number of cycles of both neoadjuvant chemotherapy and postoperative adjuvant chemotherapy; TTS, Time to interval debulking surgery after the completion of NACT. Supplementary table S3. Clinical characteristics of patients according to TTC. Abbreviation: IQR, Interquartile range; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; CA125, Cancer antigen 125; NACT, Neoadjuvant chemotherapy; Total cycles, the total number of cycles of both neoadjuvant chemotherapy and postoperative adjuvant chemotherapy; TTC, Time to postoperative adjuvant chemotherapy after the completion of neoadjuvant chemotherapy. Supplementary table S4. Univariate and multivariate logistic regression analyses for delay of TTS. Abbreviation: TTS, Time to interval debulking surgery after the completion of neoadjuvant chemotherapy; OR, Odds ratio; CI, Confidence interval; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics. Supplementary table S5. Multiple models for PFS and OS based on TI Abbreviation: PFS, Progression-free survival; OS, Overall survival; TI, Time interval from interval debulking surgery to the initiation of postoperative adjuvant chemotherapy; HR, Hazard ratio; CI, Confidence interval; *, P value for Ptrend. a Adjusted for age, type, grade, stage, residual disease, cycle of neoadjuvant chemotherapy and TI (included as a binary variable). b Adjusted for age, type, grade, stage, residual disease, cycle of neoadjuvant chemotherapy and TI (included as a quartile categorical variable). c Adjusted for age, type, grade, stage, residual disease, cycle of neoadjuvant chemotherapy and TI (included as a continuous variable). d Adjusted for age, type, grade, stage, residual disease and cycle of neoadjuvant chemotherapy. Supplementary table S6. Univariate and multivariate logistic regression analyses for delay of PACT. Abbreviation: PACT, Postoperative adjuvant chemotherapy; OR, Odds ratio; CI, Confidence interval; FIGO, International Federation of Gynecology and Obstetrics. Supplementary fig. S1. Definitions of different time intervals. NACT, Neoadjuvant chemotherapy; IDS, Interval debulking surgery; PACT, Post-operative adjuvant chemotherapy; TTS, Time to interval debulking surgery after the completion of neoadjuvant chemotherapy; TTC, Time to postoperative adjuvant chemotherapy after the completion of neoadjuvant chemotherapy; TI, Time interval from interval debulking surgery to the initiation of postoperative adjuvant chemotherapy. Supplementary fig. S2. Survival analyses according to TI. Supplementary Fig. S2A, Kaplan-Meier curves of progression-free survival of TI. Supplementary Fig. S2B, Kaplan-Meier curves of overall survival of TI. TI, Time interval from interval debulking surgery to the initiation of postoperative adjuvant chemotherapy