cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Creators: name: Malkowski, M
name: Edwards, B
name: Martin, P
name: Lord, S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: A peptide containing residues 1-50 of the Aalpha-chain of fibrinogen, expressed as a fusion peptide with beta-galactosidase, is rapidly cleaved by thrombin at Arg-16, similarly to whole fibrinogen. When Phe-8, which is highly conserved, is replaced with tyrosine (F8Y), the cleavage is slowed drastically [Lord, Byrd, Hede, Wei and Colby (1990) J. Biol. Chem. 265, 838-843]. To examine the structural basis for this result, we have determined the crystal structure of bovine thrombin complexed with a synthetic peptide containing residues 1-23 of fibrinogen Aalpha and the F8Y mutation. The crystals are in space group {"type":"entrez-protein","attrs":{"text":"P43212","term_id":"1171004","term_text":"P43212"}}P43212, with unit-cell dimensions of a = 88.3 A (1 A = 0.1 nm), c = 195.5 A and two complexes in the asymmetric unit. The final R factor is 0.183 for 2sigma data from 7.0 to 2.5 A resolution.There is continuous density for the five residues in the P3, P2, P1, P1' and P2' positions of the peptide (Gly-14f to Pro-18f) at the active site of thrombin, and isolated but well-defined density for Tyr-8f at position P9 in the hydrophobic pocket of thrombin. The tyrosine residue is shifted relative to phenylalanine in the native peptide because the phenol side chain is larger and makes a novel, intrapeptide hydrogen bond with Gly-14f. Adjacent peptide residues cannot form the hydrogen bonds that stabilize the secondary structure of the native peptide. Consequently, the 'reaction'geometry at the scissile bond, eight residues from the mutation, is perturbed and the peptide is mostly uncleaved in the crystal structure.
Electromagnetically induced absorption in a non-degenerate three-level ladder system
Creators: name: Whiting, Daniel J.
name: Bimbard, Erwan
name: Keaveney, James
name: Zentile, Mark A.
name: Adams, Charles S.
name: Hughes, Ifan G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate, theoretically and experimentally, the transmission of light through a thermal vapour of three-level ladder-type atoms, in the presence of 2 counter-propagating control fields. A simple theoretical model predicts the presence of electromagnetically induced absorption (EIA) in this pure three-level system when the control field is resonant. Experimentally, we use $^{87}$Rb in a large magnetic field of 0.62~T to reach the hyperfine Paschen-Back regime and realise a non-degenerate three-level system. Experimental observations verify the predictions over a wide range of detunings.
Double trouble: Using Excel 2010 to data mine and recover duplicate supplier payments
Creators: name: Kelly, Chris
name: Yuen, Melvin
name: Zang, Kate
name: Myburgh, Georgina
Publisher: name: figshare
Year: 2023
Subjects: Auditing and accountability

description: Accounting system controls are usually not sufficiently precise to eliminate all duplicate processed supplier invoices. This paper shows how the enhanced analytical features of Excel 2010 and its fuzzy matching add-on can be used to data mine historic paid supplier invoice data, typically transaction data downloaded from the accounting system, to detect duplicate payments which can then be recovered from the supplier. This article builds on an earlier version by Dr C Kelly published in 2004 using an earlier version of Microsoft Excel.
(100655) Frederic Henry Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Characterization of the N -Acetyl-α- d -glucosaminyl l -Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis ,
Creators: name: Redinbo, Matthew R.
name: Hamilton, Chris J.
name: Wallace, Bret D.
name: Parsonage, Derek
name: Reid, Sean D.
name: Paige, Carleitta
name: Newton, Gerald L.
name: Holder, Robert C.
name: Dos Santos, Patricia C.
name: Claiborne, Al
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Bacillithiol (Cys-GlcN-malate, BSH) has recently been identified as a novel low-molecular-weight thiol in Bacillus anthracis, Staphylococcus aureus, and several other Gram-positive bacteria lacking glutathione and mycothiol. We have now characterized the first two enzymes for the BSH biosynthetic pathway in B. anthracis, which combine to produce α-D-glucosaminyl L-malate (GlcN-malate) from UDP-GlcNAc and L-malate. The structure of the GlcNAc-malate intermediate has been determined, as have the kinetic parameters for the BaBshA glycosyltransferase (→GlcNAc-malate) and the BaBshB deacetylase (→GlcN-malate). BSH is one of only two natural products reported to contain a malyl glycoside, and the crystal structure of the BaBshA-UDP-malate ternary complex, determined in this work at 3.3 Å resolution, identifies several active-site interactions important for the specific recognition of L-malate, but not other α-hydroxyacids, as acceptor substrate. In sharp contrast to the structures reported for the GlcNAc—1-D-myo-inositol-3-phosphate synthase (MshA) apo and ternary complex forms, there is no major conformational change observed in the structures of the corresponding BaBshA forms. A mutant strain of B. anthracis deficient in the BshA glycosyltransferase fails to produce BSH, as predicted. This B. anthracis bshA locus (BA1558) has been identified in a transposon site hybridization study as required for growth, sporulation, or germination, suggesting that the biosynthesis of BSH could represent a target for development of novel antimicrobials with broad spectrum activity against Gram-positive pathogens like B. anthracis. The metabolites that function in thiol redox buffering and homeostasis in Bacillus are not well understood, and we present a composite picture based on this and other recent work.
Genome-wide identification, characterisation, and expression of C3HC4-type RING finger gene family in Capsicum annuum L
Creators: name: Dutta, Sudip Kumar
name: Nimmakayala, Padma
name: Reddy, Umesh K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified

description: C3HC4-type RING finger gene family is one of the largest, ubiquitous, and diverse proteins, involved in positive regulation of stress response, and enhances drought and salt stress tolerance. The genome-wide characterisation and biological functions of this family protein are well characterised in several plants and animals. However, their characterisation and functions in Capsicum and its related species are unknown. In this study, we identified 16 C3HC4-type RING finger family genes in pepper (Capsicum annuum L). Moreover, chromosome localisation, gene structure, phylogenetic relationships, conserved domain analysis, and cis-element analysis were carried out. In silico expression analysis was carried out to determine the level of expression of these genes in different tissues of pepper. Moreover, RT-qPCR analysis validated that CaRHC1, CaRHC7, and CaRHC13 are upregulated, while CaRHC3, CaRHC4, and CaRHC6 are downregulated in various tissues of pepper. Upregulation and downregulation of few candidate C3HC4-type RING finger genes in the placenta and pericarp of pepper indicates their possible role in capsaicin biosynthesis and pungency, which needs to be investigated further. Thus, the genome-wide analysis provides a comprehensive understanding of C3HC4-type RING finger gene family in Capsicum genome and it shall help to design effective strategies for functional analysis of these genes.
title: Multiple Papillomatosis of the Breast. Radiologic features and current management: Review of 4 patients.
Creators: name: Daguer Tamayo, Eduardo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Cancer
subject: Education
subject: MR
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To analyze the spectrum of imaging features of papillary lesions of the breast, primarily focusing on multiple papillomatosis, with clinical- radiologic correlation. 2. To review the relationship between multiple papillomatosis and atypical /...
Correction to Robust and Generic RNA Modeling Using Inferred Constraints: A Structure for the Hepatitis C Virus IRES Pseudoknot Domain
Creators: name: Lavender, Christopher A.
name: Dokholyan, Nikolay V.
name: Ding, Feng
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: RNA function is dependent on its structure, yet three-dimensional folds for most biologically important RNAs are unknown. We develop a generic discrete molecular dynamics (DMD)-based modeling system that uses long-range constraints inferred from diverse biochemical or bioinformatic analyses to create statistically significant (p < 0.01) native-like folds for RNAs of known structure ranging from 45 to 158 nucleotides. We then predict the unknown structure of the hepatitis C virus IRES pseudoknot domain. The resulting RNA model rationalizes independent solvent accessibility and cryo-electron microscopy structure information. The pseudoknot positions the AUG start codon near the mRNA channel and is tRNA-like, suggesting the IRES employs molecular mimicry as a functional strategy.
(100657) George William Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Navigation in Non-Static Environments with Autonomous Drones: A Kalman Filter Reinforcement Learning Approach
Creators: name:  GIORGIO GUGLIERI
name:   FRANCESCO MARINO
name:   AFSHIN ZEINADDINI MEYMAND
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: UAV
AUTONOMOUS NAVIGATION
REINFORCEMENT LEARNING
NON-STATIC ENVIRONMENTS
DYNAMIC ENVIRONMENTS

description: Autonomous drone systems have grown in various industries, but their effectiveness in dynamic environments remains challenging. This study addresses the issues faced in path planning and state estimation for drones operating in non-static environments. To tackle these challenges, a solution combining Kalman Filters and Advanced Reinforcement Learning (RL) Algorithms is proposed. Three RL algorithms are compared to evaluate their performance. Combining the Kalman Filter and RL techniques improves path planning and decision-making, resulting in successful navigation in simulated dynamic scenarios. The approach is designed for continuous state-action environments.
Crystal Structures of Covalent Complexes of β-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic Specificity
Creators: name: Tomberg, Joshua
name: Nicola, George
name: Davies, Christopher
name: Nicholas, Robert A.
name: Pratt, R. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Penicillin-binding proteins (PBPs) are the molecular target for the widely used β-lactam class of antibiotics, but how these compounds act at the molecular level is not fully understood. We have determined crystal structures of E. coli PBP5 as covalent complexes with imipenem, cloxacillin and cefoxitin. These antibiotics exhibit very different second order rates of acylation for the enzyme. In all three structures, there is excellent electron density for the central portion of the β-lactam, but weak or absent density for the R1 or R2 side chains. Areas of contact between the antibiotics and PBP 5 do not correlate with the rates of acylation. The same is true for conformational changes because although shift of a loop leading to an electrostatic interaction between Arg248 and the β-lactam carboxylate, which occurs completely with cefoxitin, partially with imipenem and is absent with cloxacillin, is consistent with the different rates of acylation, mutagenesis of Arg248 only decreased cefoxitin acylation two fold. Together, these data suggest that structures of post-covalent complexes of PBP 5 are unlikely to be useful vehicles for design of new covalent inhibitors of PBPs. Finally, superimposition of the imipenem-acylated complex with PBP5 in complex with a boronic acid peptidemimetic shows that the position corresponding to the hydrolytic water molecule is occluded by the ring nitrogen of the β-lactam. Since the ring nitrogen occupies a similar position in all three complexes, this supports the hypothesis that deacylation is blocked by the continued presence of the leaving group after opening of the β-lactam ring.
title: Imaging in complications of postcolorectal surgery
Creators: name: Simelane, Thabisile
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Colon
subject: Interventional non-vascular
subject: CT
subject: Fluoroscopy
subject: Ultrasound
subject: Abscess delineation
subject: Complications
subject: Surgery
subject: Abscess
subject: Fistula
subject: Multidisciplinary cancer care

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Colorectal cancer is the second most common neoplasia in males and females in Ireland. Colorectal problems are also common in Ireland. There is in the number undergoing colorectal surgery, technique depending the type and severity of the disease....
Searching for FUV line emission from $10^7$ K gas in massive elliptical galaxies and galaxy clusters as a tracer of turbulent velocities
Creators: name: Anderson, Michael E.
name: Sunyaev, Rashid
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Non-thermal pressure from turbulence and bulk flows is a fundamental ingredient in hot gaseous halos, and in the intracluster medium it will be measured through emission line kinematics with calorimeters on future X-ray spacecraft. In this paper we present a complementary method for measuring these effects, using forbidden FUV emission lines of highly ionized Iron which trace $10^7$ K gas. The brightest of these is [Fe XXI] $λ$1354.1. We search for these lines in archival HST-COS spectra from the well-known elliptical galaxies M87 and NGC4696, which harbor large reservoirs of $10^7$ K gas. We report a 2.2$σ$ feature which we attribute to [Fe XXI] from a filament in M87, and positive residuals in the nuclei of M87 and NGC4696, for which the 90\% upper limits on the line flux are close to the predicted fluxes based on X-ray observations. In a newer reduction of the data from the Hubble Spectroscopic Legacy Archive, these limits become tighter and the [Fe XXI] feature reaches a formal significance of 5.3$σ$, neglecting uncertainty in fitting the continuum. Using our constraints, we perform emission measure analysis, constraining the characteristic path length and column density of the $\sim10^7$ K gas. We also examine several sightlines towards filaments or cooling flows in other galaxy clusters, for which the fraction of gas at $10^7$ K is unknown, and place upper limits on its emission measure in each case. A medium-resolution HST-COS observation of the M87 filament for $\sim$10 orbits would confirm our detection of [Fe XXI] and measure its width.
description: accepted to MNRAS
Photon Chiral Memory Effect Stored on Celestial Sphere
Creators: name: Maleknejad, Azadeh
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This work introduces the chiral memory effect on the celestial sphere that measures the permanent change of electromagnetic fields by spin-dependent processes in bulk. Unlike the conventional memory effect based on the permanent soft shift in the gauge field itself, it is a permanent change in its spin angular momentum. The concept underlying the chiral memory (conventional memory) effect is optical spin torque (optical force) induction in bulk. Photons and EM radiation carry angular momentum, which is conserved without interactions. Chiral interactions with matter, medium, curvature, and theories with parity violation, i.e., axion-QED, transfers spin angular momentum to EM fields. In nature, such phenomena occur either on EM radiation (chiral memory) or in the vacuum of QED (vacuum chiral memory). It can be parametrized in terms of the photon's topological (axial) current at null infinity. To elude the gauge ambiguity of the topological current, we use the transverse gauge and show it is the physical part of the current suggested by its cohomology structure.
description: 23+5 pages, 6 Figs
title: Imaging of postsurgical complications occurring after thoracic surgery: review of the main surgical procedures and early and late complications
Creators: name: Cicchetti, Giuseppe
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Surgery
subject: Complications
subject: CT
subject: CT-High Resolution
subject: Conventional radiography
subject: Oncology
subject: Lung
subject: Thorax
subject: Cancer
subject: Abscess
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this work is to describe the major surgical procedures in thoracic surgery and to analyse the role of imaging modalities at our disposal, the Chest X-ray (CXR) (both the supine one in anteroposterior projection - particularly in the...
Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E
Creators: name: Sapienza, Paul J.
name: Wang, Huanchen
name: Hengel, Sarah R.
name: Ke, Hengming
name: Lee, Andrew L.
name: Zhang, Jun
name: Chang, Aram
name: Phillips, George N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: PDZ (PSD95/Discs large/ZO-1) domains are ubiquitous protein interaction motifs found in scaffolding proteins involved in signal transduction. Despite the fact that many PDZs show a limited tendency to undergo structural change, the PDZ family has been associated with long-range communication and allostery. One of the PDZ domains studied most in terms of structure and biophysical properties is the second PDZ (“PDZ2”) domain from protein tyrosine phophatase 1E (PTP1E, also known as PTPL1). Previously we showed through NMR relaxation studies that binding of the RA-GEF2 C-terminal peptide substrate results in long-range propagation of side-chain dynamic changes in human PDZ2 [Fuentes, et al., J. Mol. Biol. (2004), 335, 1105-1115]. Here, we present the first X-ray crystal structures of PDZ2 in the absence and presence of RA-GEF2 ligand, solved to resolutions of 1.65 and 1.3 Å, respectively. These structures deviate somewhat from previously determined NMR structures, and indicate that very minor structural changes in PDZ2 accompany peptide binding. NMR residual dipolar couplings confirm the crystal structures to be accurate models of the time-averaged atomic coordinates of PDZ2. The impact on side-chain dynamics was further tested with a C-terminal peptide from APC, which showed near-identical results to that of RA-GEF2. Thus, allosteric transmission in PDZ2 induced by peptide binding is conveyed purely and robustly by dynamics. 15N relaxation dispersion measurements did not detect appreciable populations of a kinetic structural intermediate. Collectively, for ligand binding to PDZ2, these data support a lock-and-key binding model from a structural perspective and an allosteric model from a dynamical perspective, which together suggest a complex energy landscape for functional transitions within the ensemble.
Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding
Creators: name: Hantgan, Roy R.
name: Stahle, Mary C.
name: Lord, Susan T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: This study demonstrates that two orthogonal events regulate integrin αIIbβ3’s interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the αIIb–β3 interface and (2) flexibility in the carboxy terminus of fibrinogen’s γ-module. The first postulate was tested by capturing αIIbβ3 on a biosensor and measuring binding by surface plasmon resonance. Binding of fibrinogen to eptifibatide-primed αIIbβ3 was characterized by a kon of ~2 × 104 L mol−1 s−1 and a koff of ~8 × 10−5 s−1 at 37 °C. In contrast, even at 150 nM fibrinogen, no binding was detected with resting αIIbβ3. Eptifibatide competitively inhibited fibrinogen’s interactions with primed αIIbβ3 (Ki ~ 0.4 nM), while a synthetic γ-module peptide (HHLGGAKQAGDV) was only weakly inhibitory (Ki > 10 µM). The second postulate was tested by measuring αIIbβ3’s interactions with recombinant fibrinogen, both normal (rFgn) and a deletion mutant lacking the γ-chain AGDV sites (rFgn γΔ408–411). Normal rFgn bound rapidly, tightly, and specifically to primed αIIbβ3; no interaction was detected with rFgn γΔ408–411. Equilibrium and transition-state thermodynamic data indicated that binding of fibrinogen to primed αIIbβ3, while enthalpy-favorable, must overcome an entropy-dominated activation energy barrier. The hypothesis that fibrinogen binding is enthalpy-driven fits with structural data showing that its γ-C peptide and eptifibatide exhibit comparable electrostatic contacts with αIIbβ3’s ectodomain. The concept that fibrinogen’s αIIbβ3 targeting sequence is intrinsically disordered may explain the entropy penalty that limits its binding rate. In the hemostatic milieu, platelet–platelet interactions may be localized to vascular injury sites because integrins must be activated before they can bind their most abundant ligand.
title: Gleichstellung von Frauen – Ja, aber …
title: Jünger und Jüngerinnen in der Jesusnachfolge und im Markusevangelium
titleType: Subtitle
Creators: name: Stowasser, Martin
Publisher: name: University of Vienna. Faculty of Catholic Theology
Year: 2023
Subjects: Neutestamentliche Bibelwissenschaft
New Testament studies
ÖFOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Philosophie, Ethik, Religion (603) -- Theologie (6032) -- Neutestamentliche Bibelwissenschaft (603214)
ÖFOS 2012 -- HUMANITIES (6) -- Philosophy, Ethics, Religion (603) -- Theology (6032) -- New Testament studies (603214)
Historical Jesus
Discipleship of Women
Ordination of Women
Gender
Narratology

description: Die Gleichstellung von Frauen und Männern ist in den christlichen Kirchen noch immer ein heiß umkämpftes Thema. In der katholischen (wie orthodoxen) Tradition ist damit zusätzlich die Frage nach dem Weiheamt verknüpft. Der Beitrag geht zunächst unter histori-schem Gesichtspunkt der Gleichstellung von Jüngern und Jüngerinnen in der Gruppe der Je-sus von Nazaret Nachfolgenden nach. In einem zweiten Teil wird die Gleichstellung von Jün-gern und Jüngerinnen im Markusevangelium unter narratologischem Gesichtspunkt analy-siert. Beide Analysen fördern die grundsätzliche Gleichstellung beider Geschlechter zutage, zeigen jedoch auch die von der antiken Gesellschaft gesetzten Grenzen einer solchen Haltung.
title: Non skeletal causes of back pain: Imaging Review
Creators: name: Simelane, Thabisile
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Arteries / Aorta
subject: Musculoskeletal soft tissue
subject: Vascular
subject: Conventional radiography
subject: CT-Angiography
subject: Digital radiography
subject: Diagnostic procedure
subject: Education
subject: Dissection
subject: Education and training
subject: Patterns of Care

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to present an imaging review ofnon-skeletalcauses of back...
Nuij type pencils of hyperbolic polynomials
Creators: name: Kurdyka, Krzysztof
name: Paunescu, Laurentiu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 15A15, 30C10, 47A56

description: Nuij's theorem states that if a polynomial $p\in \mathbb{R}[z]$ is hyperbolic (i.e., has only real roots) then $p+sp'$ is also hyperbolic for any $s\in \mathbb{R}$. We study other perturbations of hyperbolic polynomials of the form $p_a(z,s): =p(z) +\sum_{k=1}^d a_ks^kp^{(k)}(z)$. We give a full characterization of those $a= (a_1, \dots, a_d) \in \mathbb{R}^d$ for which $p_a(z,s)$ is a pencil of hyperbolic polynomials. We give also a full characterization of those $a= (a_1, \dots, a_d) \in \mathbb{R}^d$ for which the associated families $p_a(z,s)$ admit universal determinantal representations. In fact we show that all these sequences come from special symmetric Toeplitz matrices.
Research and Development of the Small LOX/Methane Propulsion System for an Experimental Reusable Winged Rocket WIRES#015
Creators: name:  TATSUYA HASHIZUME
name:   TOSHIKI MORITO1
name:   HIROYA ASAKAWA
name:   TORU TSUKANO
name:  KOICHI YONEMOTO
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: METHANE PROPULSION SYSTEM
REUSABLE ROCKET

description: LOX/Methane engines have been researched in Japan since the early 2000s, and the combustion tests of 30kN class full-expander cycle engine has been succeeded in 2021. The engine will be installed in the WIRES#Ol5 (Winged Reusable Sounding rocket) and be demonstrated in the first flight in 2025 under a collaborative research contract with the Tokyo University of Science. To operate the engine, the vehicle needs a propulsion system, including tanks, propellant supply units, electrical control units and engine gimbaling units. Research and development on the propulsion system are proceeding, and its status is described in this paper.
(100652) Alfred John Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in Neisseria gonorrhoeae : Role of Epistatic Mutations
Creators: name: Nicholas, Robert A.
name: Davies, Christopher
name: Tomberg, Joshua
name: Unemo, Magnus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Mutations in penicillin-binding protein 2 (PBP 2) encoded by mosaic penA alleles are critical for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae. Three of the ~60 mutations present in mosaic alleles of penA, G545S, I312M, and V316T, have been reported to be responsible for increased resistance, especially to cefixime (Takahata et al. 2006. Antimicrob Agents Chemother 50:3638-45). However, we observed that the minimum inhibitory concentrations (MICs) of penicillin, ceftriaxone, and cefixime for a wild type strain (FA19) containing a penA gene with these three mutations increased only 1.5-, 1.5-, and 3.5-fold, respectively. In contrast, when these three mutations in a mosaic penA allele (penA35) were reverted back to wild type and the gene transformed into FA19, the MICs of the three antibiotics were reduced to near wild type levels. Thus, these three mutations display epistasis, in that their capacity to increase resistance to β-lactam antibiotics is dependent on the presence of other mutations in the mosaic alleles. We also identified an additional mutation, N512Y, that contributes to decreased susceptibility to expanded-spectrum cephalosporins. Finally, we investigated the effects of a mutation (A501V) currently found only in non-mosaic penA alleles on decreased susceptibility to ceftriaxone and cefixime, under the expectation that this mutation may arise in mosaic alleles. Transfer of the mosaic penA35 allele containing an A501V mutation into FA6140, a chromosomally mediated penicillin-resistant isolate, increased the MICs of ceftriaxone (0.4 μg/ml) and cefixime (1.2μg/ml) to levels above their respective breakpoints. The proposed structural mechanisms of these mutations are discussed in light of the recently published structure of PBP 2.
Leslie P. Wenham, The Romano-British Cemetary at Trentholme Drive, York
Creators: name: Nuber, Hans Ulrich
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Rezension zu: Leslie P. Wenham, The Romano-British Cemetary at Trentholme Drive, York. With Contributions by E. Birley, J. P. Gillam, D. B. Harden, J. P. C. Kent, G. Simp­son, W. V. Wade. With a Report on the Skeletal Remains by Roger Warwick and a Dental Report by Colin Cooke and T. Charles Rowbotham. Ministry of Public Building and Works, Archaeological Reports No. 5. Her Majesty’s Stationery Office, London 1968. XII und 223 S., 47 Abb., 26 Tabellen und 53 Tafeln.
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 50 (1972)
Novel strategies for septic shock management : based on current guidelines and research
Creators: name: Lanka, Gandhi Bhaskar Patrudu
Publisher: name: International Journal of Medical Conference Presentations (IJMCP)
Year: 2020

description: Abstract:Background: Septic shock remains a leading cause of mortality despite advances in critical care. Recent updates and guidelines have shifted clinical approaches to improve recognition and management. This review highlights the role of various clinical tools, interventions, and therapeutic strategies in managing septic shock. Objective: To examine thecurrent clinical strategies and guidelines in recognizing and treating septic shock, with emphasison occult septic shock, fluid resuscitation, vasopressor usage, and the role of steroids, lactate monitoring, and procalcitonin in prognosis. Methods: A comprehensive review of the literature, including the latest guidelines from the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), the Surviving Sepsis Campaign, and retrospective studies comparing clinical tools such as SIRS, qSOFA, and NEWS for early identification of septic shock. Results: 1. Recognition of Septic Shock: - SIRS, qSOFA, and NEWS were evaluated, with NEWSemerging as a more accurate tool for early recognition. - Lactate and procalcitonin are valuable markers but have limitations in predicting patient outcomes.2. Resuscitation Strategies:- Ringer's Lactate is preferred over saline for initial resuscitation due to Conclusion: Effective management of septic shock involves early recognition using appropriate clinical tools like NEWS, aggressive fluid resuscitation with balanced crystalloids, timely initiation of vasopressors, and careful consideration of steroids and antibiotics. Further large-scale randomized controlled trials are needed to refine these approaches, particularly in vasopressor and steroid administration.the latter’s association with hyperchloremic acidosis. - The recommended fluid resuscitation strategy includes rapid administration of 30mL/kg crystalloid for hypotension or lactate > 4 mmol/L.3. Vasopressor and Steroid Use: - Early norepinephrine administration is recommended to maintain a MAP > 65 mmHg. - Vasopressin is the second-line vasopressor, though its benefits in reducing mortality are uncertain. - Steroids, particularly in conjunction with vitamin C and thiamine, may improve outcomes in vasopressor-refractory septic shock.4. Antibiotic Timing and Administration: - Early antibiotic administration, ideally within one hour of sepsis diagnosis, significantly improves survival rates.Keywords: Septic shock, SIRS, qSOFA, NEWS, lactate, procalcitonin, norepinephrine, vasopressin, fluid resuscitation, antibiotics.
title: Basic and advanced temporal bone anatomy using different figures as landmarks.
Creators: name: De Brucker, Yannick
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Education
subject: CT
subject: Cone beam CT
subject: Ear / Nose / Throat

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To master the detailed CT anatomy of the middle and inner ear To make use of several recognizable figures as landmarks for positioning To be able to recognize potential pathology in areas affecting the normal anatomy To understand the concept of...
Constrained Approximation of Effective Generators for Multiscale Stochastic Reaction Networks and Application to Conditioned Path Sampling
Creators: name: Cotter, Simon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: Efficient analysis and simulation of multiscale stochastic systems of chemical kinetics is an ongoing area for research, and is the source of many theoretical and computational challenges. In this paper, we present a significant improvement to the constrained approach, which is a method for computing effective dynamics of slowly changing quantities in these systems, but which does not rely on the quasi-steady-state assumption (QSSA). The QSSA can cause errors in the estimation of effective dynamics for systems where the difference in timescales between the "fast" and "slow" variables is not so pronounced. This new application of the constrained approach allows us to compute the effective generator of the slow variables, without the need for expensive stochastic simulations. This is achieved by finding the null space of the generator of the constrained system. For complex systems where this is not possible, or where the constrained subsystem is itself multiscale, the constrained approach can then be applied iteratively. This results in breaking the problem down into finding the solutions to many small eigenvalue problems, which can be efficiently solved using standard methods. Since this methodology does not rely on the quasi steady-state assumption, the effective dynamics that are approximated are highly accurate, and in the case of systems with only monomolecular reactions, are exact. We will demonstrate this with some numerics, and also use the effective generators to sample paths of the slow variables which are conditioned on their endpoints, a task which would be computationally intractable for the generator of the full system.
description: 31 pages, 7 figures
Circular Research Data Bootcamp: A use case for FAIR training materials
Creators: name: Hernández Serrano, Pedro V
name: Vivas Romero, Maria
Publisher: name: Zenodo
Year: 2022
Subjects: FAIR Digital Objects
FAIR
Research Data Management
Research Data Reuse

description: Original link to the event LCRDM Networking Day 2022 In this workshop, we will discuss how to deconstruct the FAIR principles into the 6 basic steps of Circular Research Data.
 This way, teaching RDM becomes more practical, especially with Interoperability and Reusability.
 The participants will also learn how to create FAIR training materials, i.e. machine and human-readable, complying with the FAIR digital objects specification. Resources used in the workshop FAIR Metadata Wizard: maastrichtu-ids.github.io/fair-metadata-wizard/ Metadata template for FAIR training material: bit.ly/FAIRmetadata Circular Research Data Coursebook: maastrichtu-library.github.io/circular-research-data-coursebok/ Web Slides: Circular Research Data Bootcamp: A use case for FAIR training materials Instructor Bio: Pedro Is the Faculty Data Steward at the Faculty of Science and Engineering, Maastricht University.
 He centrally supports activities, policy development and technical infrastructure at the University Library for data stewardship professionalisation He recently got awarded the Netherlands eScience Center fellowship to coordinate activities on FAIR Research Software in his institution.
description: {"references": ["Hernandez Serrano, Pedro V, & Vivas Romero, Maria. (2022, August 8). Circular Research Data Bootcamp. Zenodo. https://doi.org/10.5281/zenodo.6974103"]}
Nonhierarchical Ribonucleoprotein Assembly Suggests a Strain-Propagation Model for Protein-Facilitated RNA Folding
Creators: name: Duncan, Caia D.S.
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Proteins play diverse and critical roles in cellular ribonucleoproteins (RNPs) including promoting formation of and stabilizing active RNA conformations. Yet, the conformational changes required to convert large RNAs into an active RNPs have proven difficult to characterize fully. Here we use high-resolution approaches to monitor both local nucleotide flexibility and solvent accessibility for nearly all nucleotides in the bI3 group I intron RNP in four assembly states: the free RNA, maturase-bound RNA, Mrs1-bound RNA, and the complete six-component holocomplex. The free RNA is misfolded relative to the secondary structure required for splicing. The maturase and Mrs1 proteins each stabilized long-range tertiary interactions but neither protein alone induced folding into the functional secondary structure. In contrast, simultaneous binding by both proteins results in large secondary structure rearrangements in the RNA and yielded the catalytically active group I intron structure. Secondary and tertiary folding of the RNA component of the bI3 RNP are thus not independent: RNA folding is strongly non-hierarchical. These results emphasize that protein-mediated stabilization of RNA tertiary interactions functions to pull the secondary structure into an energetically disfavored, but functional, conformation and emphasize a new role for facilitator proteins in RNP assembly.
Numerical simulation of phase change induced by pressure variations in cryogenic tanks
Creators: name:  ANNAFEDERICA URBANO
name:   MARIE BIBAL
name:   MAXENCE DEFERREZ
name:   SEBASTIEN TANGUY
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: CRYOGENICS
PHASE CHANGE
COMPRESSIBLE TWO PHASE FLOWS
REFUELLING
TANKS
DEPOTS

description: Cavitation at the wall in tanks, characterised by fast bubbles growth in a superheated liquid, can be a great concern for cryogenic fluids storage in upper stages or fuel depots. Indeed, one cooling strategy, adopted in particular for conditioning the propellant before ignition, consists in depressurising the tank by venting the propellant, in order to create vapour and reduce the liquid propellant temperature. The tank thermal control is in the end strongly affected by phenomena arising at the bubble scale, and in the contact line region, that need to be predicted. In order to study these phenomena, without making use of sub-grid models for the phase change mass flow rate thermal gradients at the interface need to be solved with a direct numerical simulation (DNS). Moreover, for the simulation of pool cavitation, a compressible two-phase flow solver, including phase change, is required. In the present work, an innovative numerical algorithm for the DNS of compressible two-phase flows with phase change is presented. The solver is based on a level set/ ghost fluid approach, solves the complete set of Navier-Stokes conservation equations making use of a semi-implicit projection scheme. Cubic equations of state are used for the description of both the liquid, the vapour and the saturation conditions at the interface. In this paper the solver is introduced with particular attention devoted to the phase change modelling. The solver is used to investigate the cavitation of a methane bubble at the wall in micro-gravity conditions in a closed tank. After comparison with experimental data, a preliminary parametric study is carried out in order to investigate the influence of different depressurisation levels and rates on the bubble growth.
(100654) Emily Helena Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A combined marginal social cost approach for automobile emissions and congestion
Creators: name: Agarwal, Amit
name: Kickhöfer, Benjamin
Publisher: name: Technische Universität Berlin
Year: 2014
Subjects: subject: 629 Andere Fachrichtungen der Ingenieurwissenschaften
subject: air pollution
subject: congestion
subject: vehicle emissions
subject: road pricing
subject: simultaneous pricing
subject: agent-based modeling

description: Increasing emissions from road transport is a growing concern for planners and policy makers. Concurrently, congestion is another major issue which affects user behavior, escalates emissions and other externalities, and thus, reduces system welfare. Recent contributions in the literature investigated the interrelationship between congestion and emission levels, and find them to be positively correlated. However, most studies focus on pricing strategies to mitigate one isolated externality, and examine impacts on the other externality. This paper continues this line of research by investigating the effect of congestion pricing on emission levels, and the effect of emission pricing on congestion levels for a large-scale case study of Sioux Falls (South Dakota, US). Going beyond existing studies, the paper then proposes a joint optimization approach of internalizing both externalities simultaneously, and analyzes the effect of different available choice dimensions for users (route, mode, and departure time choice) on the results. The findings for separate pricing of the externalities are in line with the literature, and indicate a positive correlation between congestion and emissions. Furthermore, it is found that simultaneous pricing of congestion and emissions yields a higher increase in system welfare than separate pricing of only one externality. Mode choice turns out to be the determining factor of this welfare change, and therefore needs to be included in the transport model. Finally, the case study shows that simply combining the toll levels obtained from the separate pricing strategies will most likely result in tolls above the economic optimum, and thus, reduce overall welfare.
p90 Ribosomal S6 Kinase 2, a Novel GPCR Kinase, Is Required for Growth Factor-Mediated Attenuation of GPCR Signaling
Creators: name: Strachan, Ryan T.
name: Roth, Bryan L.
name: Allen, John A.
name: Sheffler, Douglas J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The 5-hydroxytryptamine 2A (5-HT2A) receptor is a member of the G protein-coupled receptor superfamily (GPCR) and plays a key role in transducing a variety of cellular signals elicited by serotonin (5-HT; 5-hydroxytryptamine) in both peripheral and central tissues. Recently, we discovered that the ERK/MAPK effector p90 ribosomal S6 kinase 2 (RSK2) phosphorylates the 5-HT2A receptor and attenuates 5-HT2A receptor signaling. This raised the intriguing possibility of a regulatory paradigm whereby receptor tyrosine kinases (RTKs) attenuate GPCR signaling (i.e., ‘inhibitory cross-talk’) by activating RSK2 [Strachan et al. (2009) J. Biol. Chem. 284, 5557-5573]. We report here that activation of multiple endogenous RTKs such as the epidermal growth factor receptor (EGFR), the platelet-derived growth factor receptor (PDGFR), and ErbB4 significantly attenuates 5-HT2A receptor signaling in a variety of cell types including mouse embryonic fibroblasts (MEFs), mouse vascular smooth muscle cells (mVSMCs), and primary cortical neurons. Importantly, genetic deletion of RSK2 completely prevented signal attenuation, thereby suggesting that RSK2 is a critical mediator of inhibitory cross-talk between RTKs and 5-HT2A receptors. We also discovered that P2Y purinergic receptor signaling was similarly attenuated following EGFR activation. By directly testing multiple endogenous growth factors/RTK pathways and multiple Gq-coupled GPCRs, we have now established a cellular mechanism whereby RTK signaling cascades act via RSK2 to attenuate GPCR signaling. Given the pervasiveness of growth factor signaling, this novel regulatory mechanism has the potential to explain how 5-HT2A receptors are regulated in vivo, with potential implications for human diseases in which 5-HT2A or RTK activity is altered (e.g. neuropsychiatric and neurodevelopmental disorders).