cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Late Time Observations of the Afterglow and Environment of GRB 030329
Creators: name: Taylor, G. B.
name: Momjian, E.
name: Pihlstrom, Y.
name: Ghosh, T.
name: Salter, C.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present Very Long Baseline Interferometry (VLBI) observations 217 days after the gamma-ray burst of 2003 March 29. These observations provide further measurements of the size and position of GRB 030329 that are used to constrain the expansion rate and proper motion of this nearby GRB. The expansion rate appears to be slowing down with time, favoring expansion into a constant density interstellar medium, rather than a circumstellar wind with an r^-2 density profile. We also present late time Arecibo observations of the redshifted HI and OH absorption spectra towards GRB 030329. No absorption (or emission) is seen allowing us to place limits on the atomic neutral hydrogen of N_H < 8.5 x 10^20 cm^-2, and molecular hydrogen of N_H_2 < 1.4 x 10^22 cm^-2. Finally, we present VLA limits on the radio polarization from the afterglow of <2% at late times.
description: 6 pages, 5 figures, Accepted to ApJ on Dec. 17, 2004
Mid-Frequency Gravitational Wave Detection and Sources
Creators: name: Ni, Wei-Tou
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: A brief history and various themes of mid-frequency gravitational wave detection are presented more or less following historical order -- Laser Interferometry, Atom Interferometry (AI), Torsion Bar Antenna (TOBA), and Superconducting Omni-directional Gravitational Radiation Observatory (SOGRO). Both Earth-based and Space-borne concepts are reviewed with outlook on expected astrophysical sources
description: reference update and minor corrections
The hazardous (mis)perception of Self-estimated Alcohol intoxication and Fitness to drivE-an avoidable health risk: the SAFE randomised trial.
Creators: name: Köchling, Jöran
name: Geis, Berit
name: Chao, Cho-Ming
name: Dieks, Jana-K
name: Wirth, Stefan
name: Hensel, Kai O
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
DRKS00015285
DRKS
Alcohol Harm Reduction 2021 and Beyond: Current Status of Policy, Programs and Practices
Perceived alcohol intoxication
Road safety
Public health concern
Alcohol-related road traffic accident
Driving under the influence
DUI
Drink-driving

description: Funder: Carlsberg GmbH
description: BACKGROUND: Worldwide, alcohol-related road traffic accidents represent a major avoidable health risk. The aim of this study was to evaluate the accuracy of self-estimating the degree of acute alcohol intoxication regarding the legal driving limit, and to identify risk factors for misjudgement. METHODS: In this prospective randomised controlled crossover trial, 90 social drinkers (mean age 23.9 ± 3.5 years, 50% female) consumed either beer or wine. Study group subjects were made aware when exceeding the legal driving limit (BrAC = 0.05%). Controls received no information about their BrAC. For crossover, beer or wine were consumed in the opposite order. RESULTS: 39-53% of all participants exceeded the legal driving limit whilst under the impression to be still permitted to drive. Self-estimation was significantly more accurate on study day 2 (p = 0.009). Increasing BrAC positively correlated with self-estimation inaccuracy, which was reproducible during crossover. Multiple regression analysis revealed fast drinking and higher alcohol levels as independent risk factors for inaccurate self-estimation. CONCLUSIONS: Social drinkers are commonly unaware of exceeding the legal driving limit when consuming alcohol. Self-estimating alcohol intoxication can be improved through awareness. Dedicated awareness programs, social media campaigns and government advice communications should be utilised to address this avoidable hazard. Trial registration The trial was registered prospectively at the Witten/Herdecke University Ethics Committee (trial registration number 140/2016 on 04/11/2016) and at the DRKS-German Clinical Trials Register (trial registration number DRKS00015285 on 08/22/2018-Retrospectively registered). Trial protocol can be accessed online.
Many-body effects, orbital mixing and cyclotron resonance in bilayer graphene
Creators: name: Shizuya, K.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In a magnetic field bilayer graphene supports, at the lowest Landau level, eight characteristic zero-energy levels with an extra twofold degeneracy in Landau orbitals $n=\{0,1\}$. They, under general one-body and many-body interactions, evolve into pseudo-zero-mode (PZM) levels. A close look is made into the detailed structure and characteristics of such PZM levels and cyclotron resonance they host, with full account taken of spin splitting, interlayer bias, weak electron-hole asymmetry and Coulomb interactions. It is pointed out that the PZM levels generally undergo orbital level mixing (in one valley or both valleys) as they are gradually filled with electrons and that an observation of interband cyclotron resonance over a finite range of filling provides a direct and sensitive probe for exploring many-body effects and orbital mixing in bilayer graphene.
description: 13 pages, 6 figures, revtex
Synthesis of tunable $SnS-TaS_2$ nanoscale superlattices
Creators: name: Roberts, Dennice M.
name: Bardgett, Dylan
name: Perkins, John D.
name: Gorman, Brian P.
name: Zakutayev, Andriy
name: Bauers, Sage R.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Nanoscale superlattices represent a compelling platform for designed materials as the specific identity and spatial arrangement of constituent layers can lead to tunable properties. A number of kinetically-stabilized layered chalcogenide nanocomposites have taken inspiration from misfit compounds, a thermodynamically stable class of materials formed of van der Waals-bonded (vdW) layers. This class of vdW heterostructure superlattices have been reported in telluride and selenide chemistries, but have not yet been extended to sulfides. Here we present $SnS-TaS_2$ nanoscale superlattices with tunable layer architecture. Thin films are prepared from layered amorphous precursors and deposited to mimic the targeted superlattice; subsequent low temperature annealing activates self-assembly into designed nanocomposites. Structure and composition for materials are investigated that span stacking sequences between $[(SnS)_{1+δ}]_3(TaS_2)_1$ and $(SnS)_7(TaS_2)_1$ using x-ray diffraction, x-ray fluorescence, and transmission electron microscopy. A graded deposition approach is implemented to stabilize heterostructures of multiple stacking sequences with a single preparation. Precise control over the architecture of such nanoscale superlattices is a critical path towards controlling the properties of quantum materials and constituent devices.
The Rest-Frame FUV Morphologies of Star-Forming Galaxies at z ~ 1.5 and z ~ 4
Creators: name: Lotz, J. M.
name: Madau, P.
name: Giavalisco, M.
name: Primack, J.
name: Ferguson, H. C.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We apply a new approach to quantifying galaxy morphology and identifying galaxy mergers to the rest-frame far-ultraviolet images of 82 z ~ 4 Lyman break galaxies (LBGs) and 55 1.2 < z < 1.8 emission-line galaxies in the GOODS and Ultra Deep Fields. We compare the distributions of the Gini coefficient (G), second-order moment of the brightest 20% of galaxy light (M20), and concentration (C) for high-redshift and low-redshift galaxies with average signal to noise per pixel > 2.5 and Petrosian radii > 0.3 arcsec. Ten of the 82 LBGs have M20 >= -1.1 and possess bright double or multiple nuclei, implying a major-merger fraction of star-forming galaxies ~ 10-25% at M_{FUV} < -20, depending on our incompleteness corrections. Galaxies with bulge-like morphologies (G >= 0.55, M20 < -1.6) make up ~ 30% of the z ~ 4 LBG sample, while the remaining ~ 50% have G and M20 values higher than expected for smooth bulges and disks and may be star-forming disks, minor-mergers or post-mergers. The star-forming z ~ 1.5 galaxy sample has a morphological distribution which is similar to the UDF z ~ 4 LBGs, with an identical fraction of major-merger candidates but fewer spheroids. The observed morphological distributions are roughly consistent with current hierarchical model predictions for the major-merger rates and minor-merger induced starbursts at z ~ 1.5 and ~4. We also examine the rest-frame FUV-NUV and FUV-B colors as a function of morphology and find no strong correlations at either epoch.
description: accepted by the Astrophysical Journal; 19 pages, including 13 figures and 1 table
Layered Foam/Film Polymer Nanocomposites with Highly Efficient EMI Shielding Properties and Ultralow Reflection.
Creators: name: Ma, Li
name: Hamidinejad, Mahdi
name: Zhao, Biao
name: Liang, Caiyun
name: Park, Chul B
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
Microwave absorption and electromaganetic shielding
2D MXene nanosheets
SiC nanowires
Layered foam/film polymer nanocomposites
Microcellular structure
Absorption-dominated EMI shielding

description: Funder: Shanghai Jiao Tong University
description: Lightweight, high-efficiency and low reflection electromagnetic interference (EMI) shielding polymer composites are greatly desired for addressing the challenge of ever-increasing electromagnetic pollution. Lightweight layered foam/film PVDF nanocomposites with efficient EMI shielding effectiveness and ultralow reflection power were fabricated by physical foaming. The unique layered foam/film structure was composed of PVDF/SiCnw/MXene (Ti3C2Tx) composite foam as absorption layer and highly conductive PVDF/MWCNT/GnPs composite film as a reflection layer. The foam layer with numerous heterogeneous interfaces developed between the SiC nanowires (SiCnw) and 2D MXene nanosheets imparted superior EM wave attenuation capability. Furthermore, the microcellular structure effectively tuned the impedance matching and prolonged the wave propagating path by internal scattering and multiple reflections. Meanwhile, the highly conductive PVDF/MWCNT/GnPs composite (~ 220 S m-1) exhibited superior reflectivity (R) of 0.95. The tailored structure in the layered foam/film PVDF nanocomposite exhibited an EMI SE of 32.6 dB and a low reflection bandwidth of 4 GHz (R
Additional file 3 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Creators: name: Kloehn, Joachim
name: Oppenheim, Rebecca D.
name: Ghizal Siddiqui
name: Pieter-Jan De Bock
name: Dogga, Sunil Kumar
name: Yohann Coute
name: Mohamed-Ali Hakimi
name: Creek, Darren J.
name: Soldati-Favre, Dominique
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3 : Figure S2. Alterations in metabolite abundances and FA labelling in ΔACL/iΔACS parasites. PDF image providing an (a) overview of metabolites which were significantly altered in their abundance in ΔACL/iΔACS parasites compared to RH (RH abundance = 1). Metabolites were grouped according to their class. Error bars indicate the standard deviation between triplicates. All displayed metabolites were found to be significantly de- or increased by t-test (p<0.05). (b) Fractional 13C-labelling from U-13C-glucose (U-13C-Glc) and U-13C-acetate (U-13C-Ac) in myristate (FA C14:0) and FA C26:1 was measured by GC-MS following labelling of RH and ΔACL/iΔACS parasites for 16 hours during simultaneous ACS depletion. Error bars represent the standard deviation between replicates. Statistical significance was test using a t-test and is as indicated (* - p<0.05; *** - p<0.0001). Abbreviations: ACL: ATP-citrate lyase; ACS: acetyl-CoA synthetase; FA: fatty acid; GC-MS: gas chromatography-mass spectrometry; Glc: glucose; Ac: acetate.
Broken covariance of particle detector models in relativistic quantum information
Creators: name: Martín-Martínez, Eduardo
name: Perche, T. Rick
name: Torres, Bruno de S. L.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that the predictions of spatially smeared particle detectors coupled to quantum fields are not generally covariant outside the pointlike limit. This lack of covariance manifests itself as an ambiguity in the time-ordering operation. We analyze how the breakdown of covariance affects typical detector models in quantum field theory such as the Unruh-DeWitt model. Specifically, we show how the violations of covariance depend on the state of the detectors-field system, the shape and state of motion of the detectors, and the spacetime geometry. Furthermore, we provide the tools to explicitly evaluate the magnitude of the violation, and identify the regimes where the predictions of smeared detectors are either exactly or approximately covariant in perturbative analyses.
description: 12 pages. RevTeX 4.1. V2. Corrected minor typos
Additional file 3 of School-related physical activity interventions and mental health among children: a systematic review and meta-analysis
Creators: name: Andermo, Susanne
name: Hallgren, Mats
name: Thi-Thuy-Dung Nguyen
name: Jonsson, Sofie
name: Petersen, Solveig
name: Friberg, Marita
name: Romqvist, Anja
name: Stubbs, Brendon
name: Elinder, Liselotte Schäfer
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Online resource 3. Implementation factors.
Policy brief formulating recommendations based on the research of the innovation strand of the "Prevention & early detection (behavioural change)'' annual cluster meeting (year 1)
Creators: name: MELIORA Consortium
Publisher: name: Zenodo
Year: 2025
Subjects: Cancer Prenvetion
Policy Recommendations
Horizon Europe
Behavioural Change
AI
Digital Health
EU Mission on Cancer

description: This policy brief presents the first set of policy recommendations developed from the Prevention & Early Detection (Behavioural Change) Cluster’s annual meeting, held in Barcelona in September 2024. The recommendations, informed by the iBeChange, MELIORA, and SUNRISE projects, highlight key strategies for promoting cancer prevention through sustainable behavioural change. The document identifies policy gaps, proposes actionable solutions, and explores pathways for integrating innovative approaches into national and European cancer prevention frameworks. These recommendations will be further refined as research progresses.
Infrared signature of the charge-density-wave gap in $ZrTe_3$
Creators: name: Perucchi, A.
name: Degiorgi, L.
name: Berger, H.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The chain-like $ZrTe_3$ compound undergoes a charge-density-wave (CDW) transition at $T_{CDW}=63$ $K$, most strongly affecting the conductivity perpendicular to the chains. We measure the temperature ($T$) dependence of the optical reflectivity from the far infrared up to the ultraviolet with polarized light. The CDW gap $Δ(T)$ along the direction perpendicular to the chains is compatible for $T
Decoding accelerometry for classification and prediction of critically ill patients with severe brain injury.
Creators: name: Bhattacharyay, Shubhayu
name: Rattray, John
name: Wang, Matthew
name: Dziedzic, Peter H
name: Calvillo, Eusebia
name: Kim, Han B
name: Joshi, Eshan
name: Kudela, Pawel
name: Etienne-Cummings, Ralph
name: Stevens, Robert D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/699/375/1345
/692/699/375/1370
/692/699/375/380
/692/699/375/534
/692/617/375/1345
/692/617/375/1370
/692/617/375/380
/692/617/375/534
/639/166/985
/639/705/1042
/631/114/2415
article

description: Funder: Gates Cambridge Trust; doi: http://dx.doi.org/10.13039/501100005370
description: Funder: Office of the Provost, Johns Hopkins University; doi: http://dx.doi.org/10.13039/100012800
description: Our goal is to explore quantitative motor features in critically ill patients with severe brain injury (SBI). We hypothesized that computational decoding of these features would yield information on underlying neurological states and outcomes. Using wearable microsensors placed on all extremities, we recorded a median 24.1 (IQR: 22.8-25.1) hours of high-frequency accelerometry data per patient from a prospective cohort (n = 69) admitted to the ICU with SBI. Models were trained using time-, frequency-, and wavelet-domain features and levels of responsiveness and outcome as labels. The two primary tasks were detection of levels of responsiveness, assessed by motor sub-score of the Glasgow Coma Scale (GCSm), and prediction of functional outcome at discharge, measured with the Glasgow Outcome Scale-Extended (GOSE). Detection models achieved significant (AUC: 0.70 [95% CI: 0.53-0.85]) and consistent (observation windows: 12 min-9 h) discrimination of SBI patients capable of purposeful movement (GCSm > 4). Prediction models accurately discriminated patients of upper moderate disability or better (GOSE > 5) with 2-6 h of observation (AUC: 0.82 [95% CI: 0.75-0.90]). Results suggest that time series analysis of motor activity yields clinically relevant insights on underlying functional states and short-term outcomes in patients with SBI.
Additional file 2 of Implementation of a nurse-led self-management support intervention for patients with cancer-related pain: a cluster randomized phase-IV study with a stepped wedge design (EvANtiPain)
Creators: name: Raphaelis, Silvia
name: Frommlet, Florian
name: Mayer, Hanna
name: Koller, Antje
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Supplementary Table 1: Demographic and clinical characteristics of patients who dropped out versus patients who completed the study.
On a class of 2D integrable lattice equations
Creators: name: Ferapontov, E. V.
name: Habibullin, I. T.
name: Kuznetsova, M. N.
name: Novikov, V. S.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We develop a new approach to the classification of integrable equations of the form $$ u_{xy}=f(u, u_x, u_y, \triangle_z u \triangle_{\bar z}u, \triangle_{z\bar z}u), $$ where $\triangle_{ z}$ and $\triangle_{\bar z}$ are the forward/backward discrete derivatives. The following 2-step classification procedure is proposed: (1) First we require that the dispersionless limit of the equation is integrable, that is, its characteristic variety defines a conformal structure which is Einstein-Weyl on every solution. (2) Secondly, to the candidate equations selected at the previous step we apply the test of Darboux integrability of reductions obtained by imposing suitable cut-off conditions.
Interfacial-hybridization-modified Ir Ferromagnetism and Electronic Structure in LaMnO$_3$/SrIrO$_3$ Superlattices
Creators: name: Zhang, Yujun
name: Luo, Yong Zheng
name: Wu, Liang
name: Suzuki, Motohiro
name: Hirata, Yasuyuki
name: Yamagami, Kohei
name: Takubo, Kou
name: Ikeda, Keisuke
name: Yamamoto, Kohei
name: Yasui, Akira
name: Kawamura, Naomi
name: Lin, Chun
name: Koshiishi, Keisuke
name: Liu, Xin
name: Zhang, Jinxing
name: Hotta, Yasushi
name: Wang, X. Renshaw
name: Fujimori, Atsushi
name: Lin, Yuanhua
name: Nan, Cewen
name: Shen, Lei
name: Wadati, Hiroki
Publisher: name: arXiv
Year: 2020
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Artificially fabricated 3$d$/5$d$ superlattices (SLs) involve both strong electron correlation and spin-orbit coupling in one material by means of interfacial 3$d$-5$d$ coupling, whose mechanism remains mostly unexplored. In this work we investigated the mechanism of interfacial coupling in LaMnO$_3$/SrIrO$_3$ SLs by several spectroscopic approaches. Hard x-ray absorption, magnetic circular dichroism and photoemission spectra evidence the systematic change of the Ir ferromagnetism and the electronic structure with the change of the SL repetition period. First-principles calculations further reveal the mechanism of the SL-period dependence of the interfacial electronic structure and the local properties of the Ir moments, confirming that the formation of Ir-Mn molecular orbital is responsible for the interfacial coupling effects. The SL-period dependence of the ratio between spin and orbital components of the Ir magnetic moments can be attributed to the realignment of electron spin during the formation of the interfacial molecular orbital. Our results clarify the nature of interfacial coupling in this prototypical 3$d$/5$d$ SL system and the conclusion will shed light on the study of other strongly correlated and spin-orbit coupled oxide hetero-interfaces.
Additional file 1 of Implementation of a nurse-led self-management support intervention for patients with cancer-related pain: a cluster randomized phase-IV study with a stepped wedge design (EvANtiPain)
Creators: name: Raphaelis, Silvia
name: Frommlet, Florian
name: Mayer, Hanna
name: Koller, Antje
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Supplemental material Figure 5: Target-performance recruitment.
Some non-trivial PL knots whose complements are homotopy circles
Creators: name: Friedman, Greg
Publisher: name: arXiv
Year: 2004
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 57Q45 (Primary) 55P10 (Secondary)

description: We show that there exist non-trivial piecewise-linear (PL) knots with isolated singularities $S^{n-2}\subset S^n$, $n\geq 5$, whose complements have the homotopy type of a circle. This is in contrast to the case of smooth, PL locally-flat, and topological locally-flat knots, for which it is known that if the complement has the homotopy type of a circle, then the knot is trivial.
description: 4 pages. References added; content slightly modified
The Water Switch-ON Spatial Information Platform (SIP)
Creators: name: Calero, Joan Sala
name: Boot, Gerben
name: Dihe, Pascal
name: Arheimer, Berit
Publisher: name: Zenodo
Year: 2017
Subjects: open data
open science
open source
hydrology
fp7
h2020
INSPIRE
OGC
GEOSS

description: The amount of hydrological open data is continually growing and providing opportunities for the scientific community. Although the existing data portals (GEOSS Portal, INSPIRE community geoportal and others) enable access to open data, many users still find browsing through them difficult. Moreover, the time spent on gathering and preparing data usually results in more than the time spent on the experiment itself. Thus, any improvement on searching, understanding, accessing and using open data is greatly beneficial. The Spatial Information Platform (SIP) has been developed to tackle these issues within the SWITCH-ON European Commission funded FP7 project. The SIP has been designed as a set of tools based on open standards that provide to the user all the necessary functionalities as described in the Publish-Find-Bind (PFB) pattern. In other words, this means that the SIP helps users to locate relevant and suitable data for their experiments analysis, to access and transform it (filtering, extraction, selection, conversion, aggregation). Moreover, the SIP can be used to provide descriptive information about the data and to publish it so others can find and use it. The SIP is based on existing open data protocols such as the OGC/CSW, OGC/WMS, OpenDAP and open-source components like PostgreSQL/PostGIS, GeoServer and pyCSW. The SIP is divided in three main user interfaces: the BYOD (Browse your open dataset) web interface, the Expert GUI tool and the Upload Data and Metadata web interface. The BYOD HTML5 client is the main entry point for users that want to browse through open data in the SIP. The BYOD has a map interface based on Leaflet JavaScript libraries so that the users can search more efficiently. The web-based Open Data Registration Tool is a user-friendly upload and metadata description interface (geographical extent, license, DOI generation). The Expert GUI is a desktop application that provides full metadata editing capabilities for the metadata moderators of the project. In conclusion, the Spatial Information Platform (SIP) provides to its community a set of tools for better understanding and ease of use of hydrological open-data. Moreover, the SIP has been based on well-known OGC standards that will allow the connection and data harvesting from popular open data portals such as the GEOSS system of systems.
Single-cell mapping of DNA G-quadruplex structures in human cancer cells.
Creators: name: Hui, Winnie WI
name: Simeone, Angela
name: Zyner, Katherine G
name: Tannahill, David
name: Balasubramanian, Shankar
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/92/147
/631/61/514/2254
/631/61/212
/631/1647
/631/208/176
article

description: Funder: Herchel Smith Funds
description: G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability and cancer. Thus far most work has profiled the G4 landscape in an ensemble of cell populations, therefore it is critical to explore the structure-function relationship of G4s in individual cells to enable detailed mechanistic insights into G4 function. With standard ChIP-seq methods it has not been possible to determine if G4 formation at a given genomic locus is variable between individual cells across a population. For the first time, we demonstrate the mapping of a DNA secondary structure at single-cell resolution. We have adapted single-nuclei (sn) CUT&Tag to allow the detection of G4s in single cells of human cancer cell lines. With snG4-CUT&Tag, we can distinguish cellular identity from a mixed cell-type population solely based on G4 features within individual cells. Our methodology now enables genomic investigations on cell-to-cell variation of a DNA secondary structure that were previously not possible.
description: Cancer Research UK core grant (C9545/A19836) and Cancer Research UK programme grant (C9681/A29214). S.B. is a senior investigator of the Wellcome Trust (209441/Z/17/Z) and is funded by Herchel Smith Funds.
On Energy Conditions and Stability in Effective Loop Quantum Cosmology
Creators: name: Hossain, Golam Mortuza
Publisher: name: arXiv
Year: 2005
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In isotropic loop quantum cosmology, non-perturbatively modified dynamics of a minimally coupled scalar field violates weak, strong and dominant energy conditions when they are stated in terms of equation of state parameter. The violation of strong energy condition helps to have non-singular evolution by evading singularity theorems thus leading to a generic inflationary phase. However, the violation of weak and dominant energy conditions raises concern, as in general relativity these conditions ensure causality of the system and stability of vacuum via Hawking-Ellis conservation theorem. It is shown here that the non-perturbatively modified kinetic term contributes negative pressure but positive energy density. This crucial feature leads to violation of energy conditions but ensures positivity of energy density, as scalar matter Hamiltonian remains bounded from below. It is also shown that the modified dynamics restricts group velocity for inhomogeneous modes to remain sub-luminal thus ensuring causal propagation across spatial distances.
description: 29 pages, revtex4; few clarifications, references added, to appear in CQG
title: Children’s experiences and perceptions of drawing across the curriculum in a UK primary school
Creators: name: Rogers, Michelle
Publisher: name: University of Reading
Year: 2023

description: Drawing is central to the Art and Design Curriculum (OFSTED, 2023) in the National 
Curriculum in England (DfE, 2013) and has been recognised for its educational value; yet 
children’s engagement in drawing has been recognised to decline with age (Fava, 2019). 
Historically, research has focused on early years development, the content analysis of 
children’s graphic representations or the diagnostic assessment and practice within art therapy. 
There is little research that explores children’s responses to, and experiences and perceptions 
of, drawing in all subjects across the primary curriculum at key stage 2 (ages 7 to 11), from the 
children’s perspective. The purpose of this study is to close that gap.
This research builds on the socio-constructionist work of Vygotsky (1978, 1962) and Brooks 
(2002, 2004, 2005a, 2005b) and focuses on the process of drawing and its links to language 
acquisition and development, child development and children’s engagement with drawing. It
is influenced by early art educator’s views of drawing (Ruskin,1856-1857; Rousseau
1979/1792); Froebel, 1887) and key art educationists on children’s drawing (Adams, 2013; 
Brew, 2011; Hall, 2010; Watts, 2010; Hope, 2008; Matthews, 2003; Eisner, 2002; Efland, 
2002). It uses an Embedded mixed method case study approach framed within an interpretivist 
paradigm. Data were collected from participant observations during a six-month drawing 
intervention of daily drawing across the curriculum, child questionnaires including drawings 
of familiar subjects, and a parent questionnaire. These data were analysed using thematic 
analysis techniques.
The findings provide evidence of the ways in which the children in this study expressed their 
enjoyment of drawing and demonstrated markedly different behavioural and verbal responses 
to different drawing activities. The findings shed light on how daily drawing has potential 
benefits in the promotion of children’s vocabulary and language acquisition, communication 
and development. It builds on Ruskin’s concept of seeing, Vygotsky’s concept of Verbal
Thought (1962) and Brook’s concept of Visual Thought (2002) in relation to drawing and puts 
forward a multisensory framework of drawing that recognises the multimodal and multisensory 
nature of drawing. It sheds light on the affordances of drawing on the children’s cognitive 
awareness and development, on children’s social, emotional and well-being and children’s 
drawing engagement, ability and drawing self-efficacy, the promotion of which may help to 
reduce or ameliorate the decline in children’s drawing engagement at key stage 2. Finally, it 
sheds light on the importance of seeking the parental view in education.
It is hoped that the findings from this study provides insight into the pedagogical benefits of 
drawing for teachers and educational practitioners in the field of art,ß primary education and 
wider education knowledge.
J/psi dissociation and Adler's theorem
Creators: name: Bourque, A.
name: Gale, C.
name: Haglin, K. L.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Effective Lagrangian models of charmonium have recently been used to estimate dissociation cross sections with light hadrons. Detailed study of the symmetry properties reveals possible shortcomings relative to chiral symmetry. We therefore propose a new Lagrangian and point out distinguishing features amongst the different approaches. Using the newly proposed Lagrangian, which exhibits SU_L(4) X SU_R(4) symmetry and complies with Adler's theorem, we find dissociation cross sections with pions that are reduced in an energy dependent way, with respect to cases where the theorem is not fulfilled.
description: 9 pages, 3 figures. To appear in the proceedings of the 27th Annual Montreal-Rochester-Syracuse-Toronto (MRST) conference on High-Energy Physics (MRST 2005), Utica, New York, 16-18 May 2005
Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches.
Creators: name: Batson, C
name: Gomez, A
name: Sainbhi, AS
name: Froese, L
name: Zeiler, FA
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Pharmacology
aging
cerebral physiology
sex
TBI - traumatic brain injury
traumatic brain injury (craniocerebral trauma)

description: The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO2), Regional Cerebral Oxygen Saturations (rSO2), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI.
Charge Ordered RVB States in the Doped Cuprates
Creators: name: Huang, Huai-Xiang
name: Li, You-Quan
name: Zhang, Fu-Chun
Publisher: name: arXiv
Year: 2004
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study charge ordered d-wave resonating valence bond states (dRVB) in the doped cuprates, and estimate the energies of these states in a generalized $t-J $ model by using a renormalized mean field theory. The long range Coulomb potential tends to modulate the charge density in favor of the charge ordered RVB state. The possible relevance to the recently observed $4 \times 4$ checkerboard patterns in tunnelling conductance in high $T_c$ cuprates is discussed.
description: 4 pages, 4 figures, 3 tables
Modeling of organizational & contractual view and enhancement of physical view in support of multi-view representation of a project
Creators: name: Arsalan, Ahmad
Publisher: name: University of British Columbia
Year: 2009

description: The primary objective of the thesis is to press forward the multi-view representation of a construction project by introducing an Organizational and Contractual View of a project. The multi-view representation of a project supports a comprehensive range of construction project management functions and assists with the knowledge management function to aid management to be efficient and effective. The Organizational and Contractual View provides a comprehensive set of properties of each of the parties involved in the delivery of the project, including contact information, contract information, insurance, bonding, and warranties. The ability to evaluate the performance of project participants during the course of a project is also included in the design of this view. The evaluation matrix covers several categories considered vital for project performance and high productivity. This view when integrated with other project views assists in providing a holistic picture of a project, and directly addresses the information and communication needs of project management personnel. A drawing control system is also developed as part of the Physical View of the project, and facilitates the drawing management and control function. This thesis presents a system of tracking and coordinating architectural, engineering and shop drawings that if applied, can greatly assist in eliminating errors, omissions, mistakes, and duplications. The select, sort and content profiling of Organizational and Contractual view and drawing control system is developed which gives the ability to generate reports using all the associated information across the multi-views of project. This system can further be used for telling the as-built story of the project, which tells what happened as the project was constructed. The concepts developed for both views were implemented and tested in a prototype research system.
Intrinsically Gapless Topological Phases
Creators: name: Thorngren, Ryan
name: Vishwanath, Ashvin
name: Verresen, Ruben
Publisher: name: arXiv
Year: 2020
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Topology in quantum matter is typically associated with gapped phases. For example, in symmetry protected topological (SPT) phases, the bulk energy gap localizes edge modes near the boundary. In this work we identify a new mechanism that leads to topological phases which are not only gapless but where the absence of a gap is essential. These `intrinsically gapless SPT phases' have no gapped counterpart and are hence also distinct from recently discovered examples of gapless SPT phases. The essential ingredient of these phases is that on-site symmetries act in an anomalous fashion at low energies. Intrinsically gapless SPT phases are found to display several unique properties including (i) protected edge modes that are impossible to realize in a gapped system with the same symmetries, (ii) string order parameters that are likewise forbidden in gapped phases, and (iii) constraints on the phase diagram obtained upon perturbing the phase. We verify predictions of the general theory in a specific realization protected by $\mathbb Z_4$ symmetry, the one dimensional Ising-Hubbard chain, using both numerical simulations and effective field theory. We also discuss extensions to higher dimensions and possible experimental realizations.
description: 6 pages plus appendices
Prevention and Early Detection (Behavioural Change) Cluster Brochure
Creators: name: MELIORA Consortium
Publisher: name: Zenodo
Year: 2024

description: This brochure provides an overview of the Prevention and Early Detection (Behavioural Change) Cluster, a Horizon Europe initiative under the EU Mission on Cancer. It introduces the three collaborative research projects—iBeChange, MELIORA, and SUNRISE—and their shared strategy for fostering long-term behavioural changes to reduce cancer risk. The document highlights key areas such as digital health interventions, AI-driven prevention strategies, and policy engagement, ensuring broad impact across healthcare and research communities.
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Creators: name: Palacios-Filardo, Jon
name: Udakis, Matt
name: Brown, Giles A
name: Tehan, Benjamin G
name: Congreve, Miles S
name: Nathan, Pradeep J
name: Brown, Alastair JH
name: Mellor, Jack R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/378
/631/378/87
/631/378/3920
/631/378/548
/9/74
article

description: Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance responses in CA1 to new sensory information from entorhinal cortex whilst depressing inputs from previously encoded representations in CA3. Here, we show that excitatory inputs from entorhinal cortex and CA3 are depressed equally by synaptic release of acetylcholine in CA1. However, feedforward inhibition from entorhinal cortex exhibits greater depression than CA3 resulting in a selective enhancement of excitatory-inhibitory balance and CA1 activation by entorhinal inputs. Entorhinal and CA3 pathways engage different feedforward interneuron subpopulations and cholinergic modulation of presynaptic function is mediated differentially by muscarinic M3 and M4 receptors, respectively. Thus, our data support a role and mechanisms for acetylcholine to prioritise novel information inputs to CA1 during memory formation.
Extended superconducting dome of electron-doped cuprates after protect annealing revealed by ARPES
Creators: name: Lin, C.
name: Adachi, T.
name: Horio, M.
name: Ohgi, T.
name: Baqiya, M. A.
name: Kawamata, T.
name: Sato, H.
name: Sumura, T.
name: Koshiishi, K.
name: Nakata, S.
name: Shibata, G.
name: Hagiwara, K.
name: Suzuki, M.
name: Ono, K.
name: Horiba, K.
name: Kumigashira, H.
name: Ideta, S.
name: Tanaka, K.
name: Koike, Y.
name: Fujimori, A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The electron-doped cuprates are usually characterized by a more robust antiferromagnetic phase and a much narrower superconducting (SC) dome than those of the hole-doped counterparts. Recently, bulk single crystals of Pr1.3-xLa0.7CexCuO4-δ (PLCCO) prepared by the protect annealing method have been studied extensively and revealed many intriguing properties that were different from those obtained from samples annealed by the conventional methods. Here, we report on a systematic angle-resolved photoemission spectroscopy study of PLCCO single crystals after protect annealing. The results indicate that the actual electron concentration (nFS ) estimated from the Fermi-surface area is significantly larger than the Ce concentration x and the new nFS-based SC dome of PLCCO is more extended towards the overdoped side than the x-based SC dome derived for samples prepared using the conventional annealing method.
Magnetic field dependence of superconducting energy gaps in YNi2B2C: Evidence of multiband superconductivity
Creators: name: Mukhopadhyay, S
name: Sheet, Goutam
name: Raychaudhuri, P
name: Takeya, H
Publisher: name: arXiv
Year: 2004
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present results of in field directional point contact spectroscopy (DPCS) study in the quaternary borocarbide superconductor YNi2B2C, which is characterized by a highly anisotropic superconducting gap function. For I||a, the superconducting energy gap (D), decreases linearly with magnetic field and vanishes around 3.25T which is well below the upper critical field (Hc2~6T) measured at the same temperature (2.2K). For I||c, on the other hand, D decreases weakly with magnetic field but the broadening parameter (G) increases rapidly with magnetic field with the absence of any resolvable feature above 3.5T. From an analysis of the field variation of energy gaps and the zero bias density of states we show that the unconventional gap function observed in this material could originate from multiband superconductivity.
description: 19 pages including figures (final version)
Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.
Creators: name: Osimo, Emanuele F
name: Sweeney, Mark
name: De Marvao, Antonio
name: Berry, Alaine
name: Statton, Ben
name: Perry, Ben
name: Pillinger, Toby
name: Whitehurst, Thomas
name: Cook, Stuart A
name: O'Regan, Declan P
name: Thomas, E Louise
name: Howes, Oliver D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/699/476/1799
/692/53/2421
/692/420
/59/57
article

description: Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272
description: Funder: British Medical Association (BMA); doi: https://doi.org/10.13039/501100000374
description: Cardiovascular diseases are the leading cause of death in schizophrenia. Patients with schizophrenia show evidence of concentric cardiac remodelling (CCR), defined as an increase in left-ventricular mass over end-diastolic volumes. CCR is a predictor of cardiac disease, but the molecular pathways leading to this in schizophrenia are unknown. We aimed to explore the relevance of hypertensive and non-hypertensive pathways to CCR and their potential molecular underpinnings in schizophrenia. In this multimodal case-control study, we collected cardiac and whole-body fat magnetic resonance imaging (MRI), clinical measures, and blood levels of several cardiometabolic biomarkers known to potentially cause CCR from individuals with schizophrenia, alongside healthy controls (HCs) matched for age, sex, ethnicity, and body surface area. Of the 50 participants, 34 (68%) were male. Participants with schizophrenia showed increases in cardiac concentricity (d = 0.71, 95% CI: 0.12, 1.30; p = 0.01), indicative of CCR, but showed no differences in overall content or regional distribution of adipose tissue compared to HCs. Despite the cardiac changes, participants with schizophrenia did not demonstrate activation of the hypertensive CCR pathway; however, they showed evidence of adipose dysfunction: adiponectin was reduced (d = -0.69, 95% CI: -1.28, -0.10; p = 0.02), with evidence of activation of downstream pathways, including hypertriglyceridemia, elevated C-reactive protein, fasting glucose, and alkaline phosphatase. In conclusion, people with schizophrenia showed adipose tissue dysfunction compared to body mass-matched HCs. The presence of non-hypertensive CCR and a dysmetabolic phenotype may contribute to excess cardiovascular risk in schizophrenia. If our results are confirmed, acting on this pathway could reduce cardiovascular risk and resultant life-years lost in people with schizophrenia.