cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Can intracranial time-of-flight-MR angiography predict extracranial carotid artery stenosis?
Creators: name: Osmanodja, Filiz
name: Scheitz, Jan F.
name: Fiebach, Jochen B.
name: Ganeshan, Ramanan
name: Villringer, Kersten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Magnetic resonance angiography
subject: Stroke
subject: Intracranial embolism
subject: Carotid stenosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Extracranial stenosis of the internal carotid artery (ICA) is an important cause of ischemic stroke and transient ischemic attack (TIA). It can be diagnosed using contrast-enhanced CT or MR angiography (MRA) as well as Doppler ultrasound. In this study, we assessed the diagnostic value of intracranial time-of-flight (TOF) MRA to predict extracranial ICA stenosis (ICAS). Methods: We retrospectively analyzed consecutive patients with acute ischemic stroke or TIA and middle- (50-69%) or high-grade (70-99%) unilateral extracranial ICAS according to NASCET criteria assessed by ultrasound between January 2016 and August 2018. The control group consisted of patients without extracranial ICAS. Intraluminal signal intensities (SI) of the intracranial ICA on the side of the extracranial stenosis were compared to the contralesional side on TOF-MRA source images. SI ratios (SIR) of contralesional:lesional side were compared between groups. Results: In total, 151 patients were included in the main analysis. Contralesional:lesional SIR in the intracranial C4-segment was significantly higher in patients with ipsilateral extracranial ICA stenosis (n = 51, median 74 years, 57% male) compared to the control group (n = 100, median 68 years, 48% male). Mean SIR was 1.463 vs. 1.035 (p < 0.001) for right-sided stenosis and 1.362 vs. 1.000 (p < 0.001) for left-sided stenosis. Receiver-operating characteristic curve demonstrated a cut-off value of 1.086 for right-sided [sensitivity/specificity 75%/81%; area under the curve (AUC) 0.81] and 1.104 for left-sided stenosis (sensitivity/specificity 70%/84%; AUC 0.80) in C4 as a good predictor for high-grade extracranial ICAS. Conclusions: SIR on TOF-MRA can be a marker of extracranial ICAS.
A whole spine multibody model for predicting injury in high-rate axial loading
Creators: name: Low, Lucas
Publisher: name: Imperial College London
Year: 2023

description: Explosives have become one of the largest contributors to injury in conflicts over the past two decades. When explosives are detonated under a vehicle – termed underbody blast – the load is transferred to the occupant through the pelvis into the spine, resulting in high-rate axial loading which causes spinal injury. This PhD aims to develop a framework for generating patient-specific multibody whole spine models to study the kinematics and kinetics of the spine in underbody blast. A methodology for generating patient-specific multibody models from computed tomography scans was developed. A literature review found scarcity of data on the structural properties of the spine in underbody-blast-relevant high-rate axial loading. Therefore, experiments were conducted on intervertebral discs from four whole cadaveric human spines, across three orders of magnitude of compressive strain rates and flexion rotation rates. An inverse multibody model of the experiment was developed to analyse the experimental results. With updated structural properties determined from experiments, the multibody spine model was calibrated against lab-simulated whole body cadaveric underbody blast tests. An optimisation algorithm was implemented to aid in calibration. Three patient-specific spine models were developed and calibrated against their respective underbody blast tests. The three patient-specific models were repositioned from the baseline posture to two additional postures – leaned back and slouched forwards. The models simulated a range of underbody-blast-relevant loadcases, and injury risk was predicted using injury risk curves from the literature. Increased body mass index was found to increase injury risk in the lumbar spine; the leaned back and slouched forwards postures presented reduced injury risk in the cervical spine. Future work on the spine model includes the validation of the subject-specific models, and development of additional anthropometries to capture the variation in the population. Additionally, implementing a seat will allow the model to aid in designing and assessing injury-mitigation technologies.
Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis
Creators: name: Dao, Le-Minh
name: Machule, Marie-Luise
name: Bacher, Petra
name: Hoffmann, Julius
name: Ly, Lam-Thanh
name: Wegner, Florian
name: Scheffold, Alexander
name: Prüss, Harald
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: NMDAR encephalitis
subject: Autoantibodies
subject: T cells
subject: Cytokines
subject: Antigen-reactive T cell enrichment
subject: LGI1
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong T cell infiltration into the hippocampus. However, whether T cells react against NMDAR and their specific contribution to disease development are poorly understood. Here we characterized the ex vivo frequency and phenotype of circulating CD4(+) T helper (T-H) cells reactive to NR1 protein using antigen-reactive T cell enrichment (ARTE) in 24 patients with NMDAR encephalitis, 13 patients with LGI1 encephalitis and 51 matched controls. Unexpectedly, patients with NMDAR encephalitis had lower frequencies of CD154-expressing NR1-reactive T-H cells than healthy controls and produced significantly less inflammatory cytokines. No difference was seen in T cells reactive to the synaptic target LGI1 (Leucine-rich glioma-inactivated 1), ubiquitous Candida antigens or neoantigens, suggesting that the findings are disease-specific and not related to therapeutic immunosuppression. Also, patients with LGI1 encephalitis showed unaltered numbers of LGI1 antigen-reactive T cells. The data reveal disease-specific functional alterations of circulating NMDAR-reactive T-H cells in patients with NMDAR encephalitis and challenge the idea that increased pro-inflammatory NMDAR-reactive T cells contribute to disease pathogenesis.
An optimized imaging protocol for [99mTc]Tc-DPD scintigraphy and SPECT/CT quantification in cardiac transthyretin (ATTR) amyloidosis
Creators: name: Schatka, Imke
name: Bingel, Anne
name: Schau, Franziska
name: Bluemel, Stephanie
name: Messroghli, Daniel R.
name: Frumkin, David
name: Knebel, Fabian
name: Diekmann, Sonja M.
name: Elsanhoury, Ahmed
name: Tschöpe, Carsten
name: Hahn, Katrin
name: Amthauer, Holger
name: Rogasch, Julian M. M.
name: Wetz, Christoph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cardiac ATTR amyloidosis
subject: DPD
subject: bone scan
subject: quantification
subject: SPECT/CT
subject: CZT
subject: 90 degrees
subject: L-mode
subject: H-mode
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In [(99)mTc]Tc-DPD scintigraphy for myocardial ATTR amyloidosis, planar images 3 hour p.i. and SPECT/CT acquisition in L-mode are recommended. This study investigated if earlier planar images (1 hour p.i.) are beneficial and if SPECT/CT acquisition should be preferred in H-mode (180 degrees detector angle) or L-mode (90 degrees). Methods: In SPECT/CT phantom measurements (NaI cameras, N = 2; CZT, N = 1), peak contrast recovery (CRpeak) was derived from sphere inserts or myocardial insert (cardiac phantom; signal-to-background ratio [SBR], 10:1 or 5:1). In 25 positive and 38 negative patients reference: endomyocardial biopsy or clinical diagnosis), Perugini scores and heart-to-contralateral (H/CL) count ratios were derived from planar images 1 hour and 3 hour p.i. Results: In phantom measurements, accuracy of myocardial CRpeak at SBR 10:1 (H-mode, 0.95-0.99) and reproducibility at 5:1 (H-mode, 1.02-1.14) was comparable for H-mode and L-mode. However, L-mode showed higher variability of background counts and sphere CRpeak throughout the field of view than H-mode. In patients, sensitivity/specificity were >= 95% for H/CL ratios at both time points and visual scoring 3 hour. At 1 hour, visual scores showed specificity of 89% and reduced reader's confidence. Conclusions: Early DPD images provided no additional value for visual scoring or H/CL ratios. In SPECT/CT, H-mode is preferred over L-mode, especially if quantification is applied apart from the myocardium.
Computational approaches to predicting treatment response to obesity using neuroimaging
Creators: name: Kozarzewski, Leonard
name: Maurer, Lukas
name: Mähler, Anja
name: Spranger, Joachim
name: Weygandt, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Personalized medicine
subject: Obesity treatment
subject: Machine learning
subject: Task-fMRI
subject: Resting-state fMRI
subject: Biomarkers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Obesity is a worldwide disease associated with multiple severe adverse consequences and comorbid conditions. While an increased body weight is the defining feature in obesity, etiologies, clinical phenotypes and treatment responses vary between patients. These variations can be observed within individual treatment options which comprise lifestyle interventions, pharmacological treatment, and bariatric surgery. Bariatric surgery can be regarded as the most effective treatment method. However, long-term weight regain is comparably frequent even for this treatment and its application is not without risk. A prognostic tool that would help predict the effectivity of the individual treatment methods in the long term would be essential in a personalized medicine approach. In line with this objective, an increasing number of studies have combined neuroimaging and computational modeling to predict treatment outcome in obesity. In our review, we begin by outlining the central nervous mechanisms measured with neuroimaging in these studies. The mechanisms are primarily related to reward-processing and include "incentive salience" and psychobehavioral control. We then present the diverse neuroimaging methods and computational prediction techniques applied. The studies included in this review provide consistent support for the importance of incentive salience and psychobehavioral control for treatment outcome in obesity. Nevertheless, further studies comprising larger sample sizes and rigorous validation processes are necessary to answer the question of whether or not the approach is sufficiently accurate for clinical real-world application.
KB-beelden op Wikimedia Commons verbinden met Wikidata, NDE Hackalod, 9 april 2021
Creators: name: Olaf Janssen
Publisher: name: Zenodo
Year: 2021
Subjects: KB, national library of the Netherlands
KB Collection highlights
Koninklijke Bibliotheek
Wikimedia Commons
Wikidata
Olaf Janssen
GLAMwiki
KB Topstukken
NDE
Netwerk Digitaal Erfgoed
HackaLOD

description: Nederlands:  Structured Data on Commons (SDoC) is een project om afbeeldingen in Wikimedia Commons te voorzien van gestructureerde gegevens uit Wikidata. Hierdoor worden die afbeeldingen beter vindbaar, zichtbaar en herbruikbaar, en worden ze verbonden met de LOD-cloud. Olaf Janssen (KB) laat zien wat SDoC is,  waarom het een tof project is, wat het oplevert en hoe je er als GLAM zelf mee aan de slag kunt gaan. Hij gebruikt hierbij de Commons-beelden van de KB als voorbeeld.

Zie ook

https://web.archive.org/web/20210402070033/https://hackalod.com/index.php/2021/03/26/nieuwe-hackalod-online-9-april-thema-wikidata/

https://commons.wikimedia.org/wiki/Commons:Structured_data

https://commons.wikimedia.org/wiki/Commons:Structured_data/About/Why

https://commons.wikimedia.org/wiki/Commons:Structured_data/GLAM

https://commons.wikimedia.org/wiki/Commons:Depicts

Video registration of this presentation (Wikimedia Commons) and on Zenodo
Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer
Creators: name: Baessler, Kaven
name: Windemut, S.
name: Chiantera, V.
name: Köhler, C.
name: Sehouli, Jalid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Pelvic floor function
subject: Cervical cancer
subject: Quality of life
subject: Minimally invasive surgery
subject: Urinary incontinence
subject: Sexual function
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Despite the establishment of radical surgery for therapy of cervical cancer, data on quality of life and patient-reported outcomes are scarce. The aim of this retrospective cohort study was to evaluate bladder, bowel and sexual function in women who underwent minimally invasive surgery for early-stage cervical cancer. Methods: From 2007-2013, 261 women underwent laparoscopically assisted radical vaginal hysterectomy (LARVH = 45), vaginally assisted laparoscopic or robotic radical hysterectomy (VALRRH = 61) or laparoscopic total mesometrial resection (TMMR = 25) and 131 of them completed the validated German version of the Australian Pelvic Floor Questionnaire (PFQ). Results were compared with controls recruited from gynecological clinics (n = 24) and with urogynecological patients (n = 63). Results: Groups were similar regarding age, BMI and parity. The TMMR group had significantly shorter median follow-up (16 months versus 70 and 36 months). Postoperatively, deterioration of bladder function was reported by 70%, 57% and 44% in the LARVH, VARRVH and TMMR groups, respectively (p = 0.734). Bowel function was significantly worse after TMMR with a higher deterioration rate in 72 versus 43% (LARVH) and 47% (VARRVH) with a correspondingly higher bowel dysfunction score of 2.9 versus 1.5 and 1.8, respectively and 1.8 in urogynaecological patients. Sexual dysfunction was common in all surgical groups. 38% considered their vagina too short which was significantly associated with deep dyspareunia. Compared with controls, surgical groups had significantly increased PFQ scores. Conclusion: Pelvic floor dysfunction commonly deteriorates and negatively impacts on quality of life after minimally invasive radical hysterectomy, especially bowel function after TMMR. Pelvic floor symptoms should routinely be addressed pre- and postoperatively.
Supplementary document for Emergence of super-Poissonian light from indistinguishable single-photon emitters - 6319508.pdf
Creators: name: Slodicka, Lukas
name: Kovalenko, Artem
name: Babjak, Daniel
name: Lesundak, Adam
name: Podhora, Lukáš
name: Lachman, Lukas
name: Obšil, Petr
name: Pham, Tuan
name: Cip, Ondrej
name: Filip, Radim
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information
[The Nan'an Li Autonomy Committee Brochure]
[南安里自治委員會簡章]
Creators: name: Nan'an Li Automomy Committee
Publisher: name: The University of British Columbia
Year: 2011

description: The brochure includes the Committee's mission, the method of election, membership structure and authority, and the terms of committee members. The brochure also lists the elected members and alternate members.
Patterns of chemotherapy administration in bladder preservation therapy (BPT) for muscle-invasive bladder cancer (MIBC).
Creators: name: Crehange, Gilles
name: Yu, Evan Y.
name: Harshman, Lauren Christine
name: Nielsen, Matthew Edward
name: Wong, Yu-Ning
name: Wang, Andrew
name: Niegisch, Guenter
name: Chen, Ronald C.
name: Milowsky, Matthew I.
name: Galsky, Matt D.
name: Liontos, Michael
name: Rosenberg, Jonathan E.
name: Chowdhury, Simon
name: Smith, Angela
name: Pal, Sumanta K.
name: Rose, Tracy Lynn
name: Powles, Thomas
name: Bellmunt, Joaquim
name: Ladoire, Sylvain
Publisher: name: American Society of Clinical Oncology (ASCO)
Year: 2016

description: Background: Trimodality bladder preservation therapy (BPT) in muscle invasive bladder cancer (MIBC) includes a maximal
transurethral resection followed by concurrent chemoradiotherapy as an alternative to radical cystectomy (RC) in appropriately
selected patients, or as a treatment option in non-cystectomy candidates. Several chemotherapy regimens can be used in BPT,
but little is known about current practice patterns.
Objective: To describe utilization patterns of BPT and associated survival outcomes in MIBC.
Methods: Data were collected from the Retrospective International Study of Cancers of the UrothelialTract (RISC), a database
of 3,024 consecutive patients from 29 international academic centers from 2005 to 2013. Patients with clinical T2-T4aN0M0
urothelial cancer of the bladder were included. Results: 265 patients received BPT. Compared with the 1,447 patients who received RC, BPT patients were older, had poorer
performance status, and had more comorbidities (p < 0.01 for all). Median overall survival (OS) was similar for patients
treated with curative radiation doses in BPT and patients treated with RC (41 vs 46 months, p = 0.33, respectively). 45%
of BPT patients received concurrent chemotherapy with radiation. The most common regimens included cisplatin alone
(23%), carboplatin alone (22%), gemcitabine alone (10%), paclitaxel alone (9%), and 5-FU+mitomycin (5%). There were no
significant differences in survival among chemotherapy regimens. Only 10 patients (4% of BPT patients) underwent salvage
cystectomy.
Conclusions: In clinical practice, BPT patients have similar survival to RC patients when treated with curative radiotherapy
doses. Choice of concurrent chemotherapy regimen varied widely with no clear standard. Salvage cystectomy is rarely
performed. Continued research is needed on the comparative effectiveness among BPT and RC, and among chemotherapy
regimens in BPT.
Supplementary document for Strongly Enhanced Sensitivities of CMOS compatible Plasmonic Titanium Nitride Nanohole Arrays for Refractive Index Sensing under Oblique Incidence - 6319542.pdf
Creators: name: Han, Weijia
name: Reiter, Sebastian
name: Schlipf, Jon
name: Mai, Christian
name: Spirito, Davide
name: Jose, Josmy
name: Wenger, Christian
name: Fischer, Inga
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Supplementary document for Design and Analysis of D-shaped Fiber Optic Plasmonic Sensors using Planar and Grating Structure of Silver and Gold - 6319752.pdf
Creators: name: Kumar, Shambhu
name: Maurya, Jitendra
name: Roumi, Bita
name: Abdi-Ghaleh, Reza
name: Prajapati, Yogendra Kumar
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Full view of the 1D and 1D electric field distribution
Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer
Creators: name: Davila, Monica
name: Hisada, Yohei M.
name: Bokemeyer, Carsten
name: Amirkhosravi, Ali
name: Mahner, Sven
name: Rausch, Alma-Verena
name: Francis, John L.
name: Lezius, Susanne
name: Schmalfeldt, Barbara
name: Langer, Florian
name: Mackman, Nigel
name: Claussen, Carlota
Publisher: name: Elsevier
Year: 2016

description: BACKGROUND: Tissue factor (TF) is involved in tumor growth and metastasis and contributes to venous thromboembolism (VTE) in cancer, including gynecological malignancies. The diagnostic value of microvesicle-associated TF procoagulant activity (MV TF PCA) in women with suspected ovarian cancer, however, has not been studied.
OBJECTIVE: To evaluate MV TF PCA as a diagnostic tool in women with an ovarian mass of unknown etiology and as a predictive biomarker for perioperative VTE.
METHODS: Plasma MVs were isolated by high-speed centrifugation and analyzed for TF-specific PCA by single-stage clotting assay. In addition, plasma TF antigen and soluble P-selectin (sCD62P) were measured by ELISA.
RESULTS: D-Dimer, MV TF PCA, and sCD62P, but not the tumor marker, CA-125, significantly differentiated patients with malignant (n=40) from those with benign tumors (n=15) and healthy controls (n=34). In cancer patients, only D-Dimer and CA-125 correlated with the FIGO stage. An abnormal D-dimer had the highest sensitivity for the diagnosis of cancer, while MV TF PCA above the ROC curve-derived cut-off value of 182U/mL had the highest specificity. By multivariate logistic regression analysis, addition of MV TF PCA conferred diagnostic benefit to the single variables, CA-125 (p=0.052) and D-dimer (p=0.019). Perioperative VTE occurred in 16% of cancer patients and was associated with an advanced FIGO stage, but not MV TF PCA. There was no difference in plasma TF antigen levels between study groups.
CONCLUSIONS: MV TF PCA, but not plasma TF antigen, may provide valuable additional information for the diagnostic work-up of women with suspected ovarian cancer.
Treatment of a giant hepatic echinococcal cyst with percutaneous drainage and in vivo assessment of the protoscolicidal effect of praziquantel
Creators: name: Richter, Joachim
name: Lindner, Andreas Karl
name: Geisel, Dominik
name: Torsello, Giovanni Federico
name: Martinez, Gabriela Equihua
name: Isner, Caroline
name: Schürmann, Dirk
name: Pfäfflin, Frieder
name: Orhun, Arzu
name: Manciulli, Tommaso
name: Brunetti, Enrico
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cystic echinococcosis
subject: Echinococcus granulosus
subject: Percutaneous drainage
subject: Praziquantel
subject: Albendazole
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Therapy choices for cystic echinococcisis (CE) are stage-specific: surgical, minimally invasive, medical or observation without intervention. PAIR (percutaneous aspiration, instillation of a scolicide, and re-aspiration) has been considered the treatment of choice for uncomplicated echinococcal liver cysts. However, PAIR carries the risk of toxic cholangitis or hypernatremia and that the cyst frequently refills with bile after withdrawing the catheter. We treated a patient with a giant CE 1 liver cyst with puncture drainage (PD) under albendazole coverage. Drainage enabled us to monitor the morphology of protoscolices under praziquantel (PZQ) co-medication. Protoscolices degenerated within 5 days of PZQ 50 mg/kg/d. The cyst cavity solidified with no evidence of reactivation or secondary spread. Percutaneous treatments can replace surgery in a significant number or cases with hepatic CE. PD allows to assess microscopically the viability of protoscolices under co-medication with PZQ-albendazole and to avoid the instillation of topical scolicides.
High-level laser therapy versus scalpel surgery in the treatment of oral lichen planus: a randomized control trial
Creators: name: Tarasenko, Svetlana
name: Stepanov, Mikhail
name: Morozova, Elena
name: Unkovskiy, Alexey
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Oral lichen planus
subject: Er:YAG
subject: Nd:YAG
subject: Interleukin-6
subject: Interleukin-1
subject: Interferon
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: To compare the clinical effectiveness of various types of high-level laser therapy (HLLT) toward scalpel excision for the surgical treatment of erosive oral lichen planus (OLP). Materials and methods: The total number of 128 individuals were enrolled in the study. The 35 did not meet the inclusion criteria due to malignancy signs and presence of diabetes mellitus. In total, 8 were lost to follow-up, and 10 were excluded from the analysis, due to analgesics intake. This way 75 patients with the erosive form of OLP were analyzed in three intervention groups (Er:YAG, n = 19; Nd:YAG, n = 15; Er:YAG + Nd:YAG combination, n = 20) and one control group with scalpel excision (n = 21). The therapy effectiveness has been assessed based on the comparison of salivary interleukin (IL)-1 beta, IL-6 and interferon (IFN)-gamma preoperative levels to 14, 30 days, and 2 years postoperation, as well as pain level and time of epithelization. Results: All HLLT groups demonstrated a significantly (p > 0.05) higher IL-1 beta, IL-6, IFN gamma and pain level reduction and quicker epithelization toward the control group on the 30th day, except Nd:YAG in case of IFN gamma level. The highest IL-1 beta, IFN gamma and pain level reduction and quicker epithelization on the 30th day was observed in Er:YAG group, followed by Er:YAG + Nd:YAG combination, Nd:YAG respectively. However no significant difference was observed between the HLLT groups with regard to IL-6 level reduction. After a 2-year follow-up, no significant difference was observed between all study groups with regard to all variables. Conclusion: HLLT yields a superior clinical outcome compared to the scalpel excision for the surgical treatment of oral lichen planus, whereby the Er:YAG has been proposed as the most effective laser type at the end of the first postoperative month. Clinical relevance: For the surgical treatment of erosive OLP the Er:YAG laser may be a preferable treatment option compared to Nd:YAG and scalpel surgery. Trial registration: The present trial was registered retrospectively in the German Clinical Trials Register, as a member of WHO international clinical trials registry platform, on the 18.03.2020 with the following number: DRKS00020986.
Clinical characterization of 266 patients and family members with cleft lip and/or palate with associated malformations and syndromes
Creators: name: Bartzela, Theodosia
name: Theuerkauf, Björn
name: Reichardt, Elisabeth
name: Spielmann, Malte
name: Opitz, Charlotte
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cleft lip and palate
subject: Associated anomalies
subject: Syndromes
subject: Genetics
subject: FOS: Biological sciences
subject: Pedigrees
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To clinically characterize patients and family members with cleft lip and/or palate (CL/P) and associated congenital malformations or syndromes and propose possible inheritance patterns. Materials and methods: An observational study of patients with CL/P, including medical and family history and intra- and extra-oral examination of their family members, was performed. Results: Two hundred sixty-six patients, 1257 family members, and 42 pedigrees were included in the study. The distribution of patients according to the cleft type was 57.9% with CLP, 25.2% with cleft palate (CPO), and 12.8% with cleft lip with/without alveolus (CL/A). Seventy-four (27.8%) patients had associated malformations, and 24 (9.2%) a syndrome. The skeletal (27.7%), cardiovascular (19.3%) systems, and eyes (22.9%) were most commonly affected. Pierre Robin Sequence (7 patients) and van der Woude (4) were the most common syndromes. The majority of patients with CPO (19/24) had an associate syndrome. The families had an average of 2.45 affected members. Conclusion: Individual and interfamilial phenotypic variability in patients with CL/P makes the understanding of etiopathogenesis challenging. Clinical relevance: The overall prevalence of individuals with CL/P and their pedigrees with associated malformations and syndromes emphasize the need for early identification, interdisciplinary, and long-term planning.
ИННОВАЦИОННЫЕ ТЕХНОЛОГИИ В ПРЕПОДАВАНИИ РУССКОГО ЯЗЫКА В УЗБЕКИСТАНЕ
Creators: name: Шукурова, Муниса
name: Шавилова, Наталья
Publisher: name: Zenodo
Year: 2025

description: В статье рассматриваются особенности внедрения инновационных технологий в преподавание русского языка в Узбекистане. Анализируются современные подходы, применяемые преподавателями в условиях национальной системы образования. Особое внимание уделяется интерактивным методам, цифровым платформам и приёмам геймификации, направленным на развитие мотивации и коммуникативной компетенции учащихся
[Brief history of Hu Clan's Goose Mountain Mausoleum]
[胡族思成堂鵝山履歷冊]
Creators: name: Clan, Hu
Publisher: name: The University of British Columbia
Year: 2011

description: The brief history of Hu Clan's "Goose Mountain Mausoleum" was copied by hand by Hu Shitai. It is mainly a record of the disputes between the Hu and Nie clans.
title: Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA
title: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA)
titleType: Subtitle
Creators: name: Klimek, Ludger
name: Novak, Natalija
name: Hamelmann, Eckard
name: Werfel, Thomas
name: Wagenmann, Martin
name: Taube, Christian
name: Bauer, Andrea
name: Merk, Hans
name: Rabe, Uta
name: Jung, Kirsten
name: Schlenter, Wolfgang
name: Ring, Johannes
name: Chaker, Adam
name: Wehrmann, Wolfgang
name: Becker, Sven
name: Mülleneisen, Norbert
name: Nemat, Katja
name: Czech, Wolfgang
name: Wrede, Holger
name: Brehler, Randolf
name: Fuchs, Thomas
name: Jakob, Thilo
name: Ankermann, Tobias
name: Schmidt, Sebastian M.
name: Gerstlauer, Michael
name: Vogelberg, Christian
name: Zuberbier, Thomas
name: Hartmann, Karin
name: Worm, Margitta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Anaphylaxis
subject: BNT162b2
subject: Severe allergic reactions
subject: Vaccines
subject: mRNA
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Two employees of the National Health Service (NHS) in England developed severe allergic reactions following administration of BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for the BNT162b2 vaccine already includes reference to a contraindication for use in individuals who have had an allergic reaction to the vaccine or any of its components. As a precautionary measure, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued interim guidance to the NHS not to vaccinate in principle in "patients with severe allergies". Allergic reactions to vaccines are very rare, but vaccine components are known to cause allergic reactions. BNT162b2 is a vaccine based on an mRNA embedded in lipid nanoparticles and blended with other substances to enable its transport into the cells. In the pivotal phase III clinical trial, the BNT162b2 vaccine was generally well tolerated, but this large clinical trial, used to support vaccine approval by the MHRA and US Food and Drug Administration, excluded individuals with a "history of a severe adverse reaction related to the vaccine and/or a severe allergic reaction (e.g., anaphylaxis) to a component of the study medication". Vaccines are recognized as one of the most effective public health interventions. This repeated administration of a foreign protein (antigen) necessitates a careful allergological history before each application and diagnostic clarification and a risk-benefit assessment before each injection. Severe allergic reactions to vaccines are rare but can be life-threatening, and it is prudent to raise awareness of this hazard among vaccination teams and to take adequate precautions while more experience is gained with this new vaccine.
MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
Creators: name: Imbastari, Francesca
name: Dahlmann, Mathias
name: Sporbert, Anje
name: Mattioli, Camilla Ciolli
name: Mari, Tommaso
name: Scholz, Florian
name: Timm, Lena
name: Twamley, Shailey
name: Migotti, Rebekka
name: Walther, Wolfgang
name: Dittmar, Gunnar
name: Rehm, Armin
name: Stein, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: CME
subject: Receptor recycling
subject: MACC1
subject: Transferrin receptor
subject: EGFR
subject: Colorectal cancer
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Metastasis Associated in Colon Cancer 1 (MACC1) is a novel prognostic, predictive and causal biomarker for tumor progression and metastasis in many cancer types, including colorectal cancer. Besides its clinical value, little is known about its molecular function. Its similarity to SH3BP4, involved in regulating uptake and recycling of transmembrane receptors, suggests a role of MACC1 in endocytosis. By exploring the MACC1 interactome, we identified the clathrin-mediated endocytosis (CME)-associated proteins CLTC, DNM2 and AP-2 as MACC1 binding partners. We unveiled a MACC1-dependent routing of internalized transferrin receptor towards recycling. Elevated MACC1 expression caused also the activation and internalization of EGFR, a higher rate of receptor recycling, as well as earlier and stronger receptor activation and downstream signaling. These effects are limited by deletion of CME-related protein interaction sites in MACC1. Thus, MACC1 regulates CME and receptor recycling, causing increased growth factor-mediated downstream signaling and cell proliferation. This novel mechanism unveils potential therapeutic intervention points restricting MACC1-driven metastasis.
Supplementary document for Engineered, Pseudo and Hybrid Anapole States in Silicon Nanoresonator Metasurface - 6320222.pdf
Creators: name: Pradhan, Monica
name: Sharma, Shubhanshi
name: B.N., Shivakiran Bhaktha
name: Varshney, Shailendra
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information gives the information of field distribution pattern, scattering cross-section, normalized intensity, and phase plots
Restoration of 1325 teeth with partial-coverage crowns manufactured from high noble metal alloys: a retrospective case series 18.8 years after prosthetic delivery
Creators: name: Rehm, Philipp
name: Derks, Hermann
name: Lesaar, Wilfried
name: Spies, Benedikt Christopher
name: Beuer, Florian
name: Böse, Mats Wernfried Heinrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Dental crowns
subject: Partial-coverage crowns
subject: High noble metal alloy
subject: Prosthodontics
subject: Dental materials
subject: Tooth preservation
subject: Gold alloy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To evaluate long-term survival and success rates of conventionally cemented partial-coverage crowns (PCCs) manufactured from high noble metal alloys (hn). Material and methods: Restoration-, periodontal- and tooth-related criteria on patients, restored with a single or multiple conventionally cemented hnPCCs in a private dental office were collected from existing patient records. With regard to semi-annual follow-ups, data of the most recent clinical evaluations were considered. Kaplan-Meier and log-rank tests were used for statistical analyses. Level of significance was set at p <= .05. Results: Between 09/1983 and 09/2009, 1325 hnPCCs were conventionally cemented on 1325 teeth in 266 patients (mean age: 44.5 +/- 10.7 years). Due to various reasons, 81 hnPCCs showed complications, documenting a success rate of 93.9% after a mean observation period of 18.8 +/- 5.7 years. Of these, additional 14 restorations were counted as survival, resulting in a survival rate of 94.9%. Most frequent complications were periodontal issues (n = 29, 35.8%). Significantly higher success rates were documented for hnPCCs of patients aged between 37 and 51 years (p = .012). Conclusion: Partial-coverage crowns from high noble metal alloys showed excellent survival and success rates after a mean observation period of 18.8 +/- 5.7 years. Higher patient age was one of the risk factors. Clinical relevance: According to the results of this study, hnPCCs still represent an excellent therapeutic option-even in modern dentistry.
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?
Creators: name: McCune, Joseph M.
name: Tebas, Pablo
name: June, Carl H.
name: Lederman, Michael M.
name: Kiem, Hans-Peter
name: Mellors, John W.
name: Lewin, Sharon R.
name: Schacker, Timothy W.
name: Sekaly, Rafick P.
name: Kuritzkes, Daniel R.
name: Douek, Daniel C.
name: Cannon, Paula M.
name: Margolis, David M.
name: Walker, Bruce D.
name: Currier, Judith S.
Publisher: name: Case Western Reserve University
Year: 2016

description: With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this "salon" two editors of Pathogens and Immunity, Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion.
Evaluation of the EarthCARE aerosol classification scheme using ACTRIS/EARLINET observations
Creators: name: Voudouri, Kalliopi Artemis
name: Papagiannopoulos, Nikolaos
name: Baars, Holger
name: Floutsi, Athena Augusta
name: Haarig, Moritz
name: Wandinger, Ulla
name: Papanikolaou, Christina-Anna
name: Mona, Lucia
name: Nicolae, Doina
name: Tsichla, Maria
name: Paschou, Peristera
name: Donovan, David
name: Apituley, Arnoud
name: Diego Gouveia da Silva
name: D'Amico, Giuseppe
name: Balis, Dimitris
name: Arboledas, Lucas Alados
name: Pérez, Ana del Águila
name: Sicard, Michael
name: Gantois, Dominique
name: Marenco, Franco
name: Papetta, Alkistis
name: Kezoudi, Maria
name: Fragkos, Konstantinos
name: Freville, Patrick
name: Baray, Jean- Luc
name: Rodríguez-Gómez, Alejandro
name: Comerón, Adolfo
name: Muñoz-Porcar, Constantino
name: Filioglou, Maria
name: Komppula, Mika
name: Gebauer, Henriette
name: Amiridis, Vassilis
name: Marinou, Eleni
Publisher: name: Zenodo
Year: 2025

description: Aerosol typing has gained significant international attention as it plays an important role in identifying aerosol sources, monitoring environmental events and formulating effective mitigation strategies. Understanding the origin and characteristics of aerosols is essential to detect hazardous situations, provide early warnings and minimise their potential impacts on climate, air quality and public health.

To date, several aerosol typing schemes have been developed within ACTRIS (Aerosol, Clouds and Trace Gases Research Infrastructure) and EARLINET (European Aerosol Research Lidar Network) based on ground based lidar observations, to provide the predominant aerosol type or aerosol mixture in the atmospheric column [1,2,3]. Aerosol classification from spaceborne observations is also important to quantify the anthropogenic versus natural aerosol loading of the atmosphere and to study aerosol-cloud interactions.

The Earth Clouds, Aerosols and Radiation Explorer (EarthCARE) is a joint mission of the European Space Agency (ESA) and the Japan Aerospace Exploration Agency (JAXA) mission equipped with four sensors, a cloud-profiling radar (CPR), a high-spectral-resolution cloud–aerosol lidar (ATLID), a cloud–aerosol multi-spectral imager (MSI), and a three-view broad-band radiometer (BBR). The three instruments, i.e., ATLID, MSI, and BBR, provide information on global aerosol distribution and contribute to the overarching EarthCARE goals of sensor synergy and radiation closure with respect to aerosol presence. 

In this study we select cases with complex atmospheric conditions to evaluate the EarthCARE aerosol classification scheme [4] by comparing its performance with the ACTRIS/EARLINET dataset and the predominant aerosol types identified by the different algorithms developed within them.
The Potential Impact of Biofield Energy Treatment on the Atomic and Physical Properties of Antimony Tin Oxide Nanopowder
Creators: name: Trivedi, Mahendra
Publisher: name: SMN - The ScienceMedia Network
Year: 2016
Subjects: Natural Sciences
Chemistry

description: Antimony tin oxide (ATO) is known for its high thermal conductivity, optical transmittance, and wide energy band gap, which makes it a promising material for the display devices, solar cells, and chemical sensor industries. The present study was undertaken to evaluate the effect of biofield energy treatment on the atomic and physical properties of ATO nanopowder. The ATO nanopowder was divided into two parts: control and treated. The treated part was subjected to Mr. Trivedi’s biofield energy treatment. The control and treated samples were analyzed using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and electron spin resonance (ESR) spectroscopy. The XRD data revealed that the crystallite size on the plane (110) was significantly reduced to 53.1 nm as compared to the control (212.6 nm). In addition, the lattice parameter, unit cell volume, density, and molecular weight were also altered as compared to the control. The FT-IR spectra showed that the stretching vibration corresponding to Sn-OH was shifted to higher wavenumber (512 cm-1) in the treated sample as compared to the control (496 cm-1). Besides, ESR spectral analysis exhibited that the g-factor was reduced in the treated ATO sample by 21.1% as compared to the control. Also, the ESR signal width and height were reduced by 70.4% and 93.7%, respectively as compared to the control. Hence, the XRD, FT-IR, and ESR data revealed that the biofield energy treatment has a significant impact on the atomic and physical properties of ATO nanopowder. Therefore, the biofield energy treatment could be more useful in display devices and solar cell industries.
title: Letter: J.N.G. Finley to Subscription Manager, The New York Times, July 26, 1962
Creators: name: Finley, John Norville Gibson
Publisher: name: George Mason University
Year: 1962
Subjects: subject: Mason, George
subject: George Mason College
subject: The New York Times

description: Letter: 1 pg. typescript signed, 8.5" X 11" (29.7 cm x 21.6 cm)
description: Humorous letter written by George Mason College Director J.N.G. Finley to the subscription office manager for The New York Times, Mr. W.L. Murray, in response to a promotion sent to "Mr. George Mason". George Mason University Archives, Papers of the Presidents, Box 1A, Folder 7.
Role of CMR Imaging in Diagnostics and Evaluation of Cardiac Involvement in Muscle Dystrophies
Creators: name: Blaszczyk, Edyta
name: Gröschel, Jan
name: Schulz-Menger, Jeanette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Muscular dystrophy
subject: Cardiovascular magnetic resonance
subject: Cardiac involvement
subject: Heart failure
subject: Fat
subject: Fibrosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: This review aims to outline the utility of cardiac magnetic resonance (CMR) in patients with different types of muscular dystrophies for the assessment of myocardial involvement, risk stratification and in guiding therapeutic decisions. Recent Findings: In patients suffering from muscular dystrophies (MD), even mild initial dysfunction may lead to severe heart failure over a time course of years. CMR plays an increasing role in the diagnosis and clinical care of these patients, mostly due to its unique capability to precisely characterize subclinical and progressive changes in cardiac geometry, function in order to differentiate myocardial injury it allows the identification of inflammation, focal and diffuse fibrosis as well as fatty infiltration. CMR may provide additional information in addition to the physical examination, laboratory tests, ECG, and echocardiography. Summary Further trials are needed to investigate the potential impact of CMR on the therapeutic decision-making as well as the assessment of long-term prognosis in different forms of muscular dystrophies. In addition to the basic cardiovascular evaluation, CMR can provide a robust, non-invasive technique for the evaluation of subclinical myocardial tissue injury like fat infiltration and focal and diffuse fibrosis. Furthermore, CMR has a unique capability to detect the progression of myocardial tissue damage in patients with a preserved systolic function.
Natural sleep loss is associated with lower mPFC activity during negative distracter processing
Creators: name: Dimitrov, Annika
name: Nowak, Jonathan
name: Ligdorf, Armin
name: Oei, Nicole Y. L.
name: Adli, Mazda
name: Walter, Henrik
name: Veer, Ilya M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Sleep loss
subject: Working memory
subject: Emotional distraction
subject: Rostral anterior
subject: Cingulate cortex
subject: fMRI
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Previous research has demonstrated that loss of sleep has a negative impact on both emotional and cognitive functioning. We examined whether subjectively reported natural sleep loss is associated with the interplay between emotion and cognition, as was probed by brain activity in response to emotional distraction during a working memory task. Forty-six healthy male adults reported their typical weekly sleep pattern using the Munich Chronotype Questionnaire (MCTQ), while recent sleep loss was enquired using a sleep diary in the 7 days preceding scanning. Participants performed a delayed match-to-sample task with negative and neutral distracters during the delay period inside the MRI scanner. Activity differences between negative and neutral distracters were associated to both sleep loss measures across participants. The amount of typically encountered sleep loss indicated by the MCTQ, but not sleep diary, was negatively associated with activity in the rostral anterior cingulate cortex and dorsomedial prefrontal cortex during emotionally negative compared to neutral distraction (p < 0.025, whole brain corrected). Participants showed less distracter-related activity in the ACC and dorsomedial PFC with increasing sleep loss, which, in the long run, might contribute to less adaptive emotional processing, and therefore a greater vulnerability to develop affective disorders.
title: Letter: C. Harrison Mann, Jr. to John F. Kennedy; May 3, 1962
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Economics

description: Letter: typescript unsigned, 8.5" x 11" (21.6cm x 27.9cm)
description: Letter from C. Harrison Mann, Jr. to President John F. Kennedy praising Kennedy's handling of the rise in steel prices. C. Harrison Mann, Jr. Collection, Jr. 3.12