cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Process Evaluation of the Integrated Childsmile Programme. Report of the fifth tranche of fieldwork (August 2014 to July 2015)
Creators: name: Eaves, Jennifer
name: Williams, Nicola
name: Deas, Leigh
name: Larsen, Helle Buch
name: Gnich, Wendy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: This report provides findings from the fifth tranche of the process evaluation of the integrated Childsmile programme, covering the period August 2014 to July 2015.
Childsmile is the national, early years oral health improvement in Scotland. It comprises interacting components (Core: toothbrushing in all nurseries and targeted primary schools, provision of oral health packs at key stages; Nursery & School: fluoride varnishing provided to children in targeted educational establishments; and Practice: support for families with young children to register with and attend dental practices and to engage in protecting their children's oral health).
The purpose of the process evaluation is to explore implementation of the programme, to aid the interpretation of its outcomes.
title: Kurzformatige Evidenzsynthesen: Conjoint Analyse zur Erhebung von Nutzerpräferenzen
Creators: name: Speckemeier, Christian
name: Krabbe, Laura
name: Schwenke, Susanne
name: Wasem, Jürgen
name: Buchberger, Barbara
name: Neusser, Silke
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Politische Entscheidungsträger müssen gelegentlich innerhalb kurzer Zeit Entscheidungen über Technologien treffen, daher werden zeitsparende Formate für Evidenzsynthesen diskutiert. Bei welchen Arbeitsschritten diese zeitlichen Einsparungen erfolgen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Sex and male breeding state predict intraspecific trait variation in mouth-brooding fishes
Creators: name: Abecia, JE
name: Luiz, OJ
name: Crook, David
name: Banks, SC
name: Wedd, D
name: King, Alison
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310999
subject: Zoology not elsewhere classified
classificationCode: 310304
subject: Freshwater ecology

description: Sex-specific reproductive roles contribute to sexual dimorphic morphological trait variations. In uniparental mouth-brooding fishes, the mouth performs a reproductive function in addition to its key roles in feeding and respiration, resulting in the potential for sex-specific functional performance trade-offs. Trait differences related to parental care may occur when the individual matures or be restricted to periods when the parent is mouth-brooding. This study explored sexual dimorphism and morphological trait adaptations related to feeding, breeding, respiration and locomotion performance in two paternal mouth-brooding freshwater fishes (Glossamia aprion and Neoarius graeffei). Eight morphological traits were evaluated for sexual dimorphism (non-brooder males vs. females) and male breeding state differences (brooders vs. non-brooders). Male breeding state was a significant predictor of trait variation in both species. Brooders differed in buccal volume and in several feeding and locomotory traits compared to non-brooder males. Non-brooder males had bigger buccal volumes and relative eye diameters (G. aprion) and larger relative gape sizes (N. graeffei) compared to females, a potential response to both mouth-brooding and feeding requirements. Although there were clear trait differences between brooder and non-brooder males, further research is required to confirm whether individuals return to their former morphology once mouth-brooding has ceased or if trait differences are maintained post-brooding. This study highlights the importance of considering the potential impacts of intraspecific trait variation on the performance of critical life functions, such as feeding, respiration and locomotion across the life history.
VOTER CARD TRADING AND POLITICAL CONFLICTS IN NIGERIA: AN ANALYTICAL EXPOSITION OF 2019 DEMOCRATIC ELECTIONS IN TARABA STATE, NIGERIA.
Creators: name: Uniga, Ovenaone Jennifer
name: simon, Bodi fillah
name: Okonkwo, Ifeoma
Publisher: name: figshare
Year: 2022
Subjects: Uncategorized

description: Political conflicts are endemic in Nigeria and this is flowing from the context of its historical development, such that, a holistic approach is necessary to identify the factors that fan the embers of any conflict in Nigeria, just as in many other ill-defined federal states with plural identity groups where intergroup conflicts are common, and precipitating factors are most often, the skewed distribution of socio-economic and political resources which breed inequalities amongst culturally and sometimes religiously different groups. In juxtaposition of a structure with such prevailing practices, there will be attendant perception of injustice and marginalization wherein certain groups will construe enemy images of the government and other groups who appear to be favored by it. The study recognizes that such structures differ from place to place, and conflict management should be situated within the conflict environment. It also inform the approach of analysis of the structures and actors in such conflict contexts, like the social, economic, political, and security dimensions in any given conflict situation. As democratic elections remain indicators of early warning of violence in many states in both rural and urban settings, a study on the Permanent Voters Card (PVC) trading is necessary to determine its relationship to political conflicts with a focus on the 2019 elections violence in Taraba State and Nigeria as a whole. Bilateral bargaining theory of vote buying was the basis of the study. The study took a historical and descriptive approach, while the methodology relied on field survey, both primary and secondary sources of data were employed; such as interviews, participant observation, public documents, and library and online resources. The study recommended that the electoral management body (INEC) should be better positioned to discharge her responsibility of electoral management and mitigate conflicts emanating from political activities for sustainable peace and development in the society.
title: Published evidence of health-related quality of life benefits associated with cancer drugs approved by the European Medicines Agency between 2009 and 2015
Creators: name: Grössmann, Nicole
name: Robausch, Martin
name: Rothschedl, Eleen
name: Wild, Claudia
name: Simon, Judit
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Health-related quality of life (HRQoL) is one of the most important patient-relevant study endpoints for the direct measurement of the benefit of cancer drugs. Therefore, our aim was to detect cancer drugs with no published information on HRQoL at the time of European[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Morphological changes and reproductive costs in brooders of two mouthbrooding freshwater fishes
Creators: name: Abecia, JE
name: Luiz, OJ
name: Crook, David
name: Banks, SC
name: Wedd, DJ
name: King, Alison
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310999
subject: Zoology not elsewhere classified
classificationCode: 310304
subject: Freshwater ecology

description: Parental care purportedly promotes individual reproductive success and improves offspring survival, but is thought to come at a cost to the adult carer. Reproductive costs can be physiological such as the resources parents spend on caring but also the morphological changes that are necessary to accomplish parental care activities. This study considers morphological and body condition changes in brooders of two paternal mouthbrooder fishes – which incubate eggs and guard young inside the buccal cavity – mouth almighty (Glossamia aprion) and blue catfish (Neoarius graeffei), from rivers of northern Australia. Potential costs associated with mouthbrooding were examined by quantifying body condition, feeding deterrence and changes in gut length and gill form across individuals from varying sex-breeding state category (brooder males, nonbrooder males and females). Brooders of both species exhibited significantly lower values in some condition indices, and did not feed, suggesting that body reserves were being used and not renewed during mouthbrooding. Brooders of both species had shorter gut lengths than nonbrooders, potentially to reduce tissue maintenance costs during a time of restricted food intake and requirements. Both species also exhibited changes in gill form and structure compared to nonbrooders; indicating structural adaptive plasticity to mouthbrooding by allowing more space for egg brooding in the buccal cavity. For G. aprion and N. graeffei, caring for progeny seemingly required similar trade-offs including nonphysiological activities (e.g. feeding) and responses, such as changes in condition, respiratory and digestive morphology, that potentially allowed brooders to compensate for parental care energy expenditure.
On the Riemann Hypothesis and Other Brain Teasers
Creators: name: Smith, John
Publisher: name: figshare
Year: 2017
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics

description: Abstract In 1963, a game show called Lets Make A Deal began in the United States. On the show, the host - Monty Hall - would present contestants with the choice of 3 doors, behind only 1 of which was a car. A contestant would pick a door such as No. 1, and Monty, who knew what was behind the doors, would open another door, say No. 2, revealing a goat. Monty would then ask the contestant if they wanted to change their selection to door No. 3. It is widely accepted that the contestant should change doors on the basis that the chances of the car being behind door 3 are 2/3, whereas the chances of the car being behind door 1 are only 1/3. But by appeal to congruities that exist between this seemingly innocuous and simple problem and variety of deeper and less tractable problems, this Monty Hall is revealed as the tip of a great intellectual and iceberg.
Quantification of behavioural variation among sheep grazing on pasture using accelerometer sensors
Creators: name: Almasi, Fazel
name: Nguyen, Hien
name: Heydarian, Deniz
name: Sohi, Rajneet
name: Nikbin, Saeid
name: Jenvey, Caitlin
name: Halliwell, Emma Una
name: Ponnampalam, EN
name: Desai, Aniruddha
name: Jois, Markandeya
name: Stear, Michael
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 300399
subject: Animal production not elsewhere classified
classificationCode: 310999
subject: Zoology not elsewhere classified

description: Context: Monitoring the behaviour of animals can provide early warning signs of disease or indicate loss of appetite. Also, an understanding of the variation in behaviours among animals and their distributions is essential for meaningful statistical inference. Therefore, quantifying the variation of behaviours is of both biological and statistical interest. Aim: The objectives of this study were to determine the distributions and quantify the variation among animals with respect to the times spent grazing, ruminating, idling, walking, and licking. Methods: The activities of 147 (male = 67, female = 80) Merino lambs at 10-11 months of age on a commercial farm in Edenhope, Victoria, Australia were recorded for 26 days, using ActiGraph accelerometer sensors attached to the left side of the sheep's muzzle. The male and female sheep were kept in separate paddocks. A Support Vector Machine algorithm was used to differentiate sheep behaviour into six categories: Grazing, ruminating, idling, walking, licking, and other activities. The distributions of behaviours were analysed using energy statistics-based tests and Generalised Additive Models for Location, Scale, and Shape (GAMLSS). Different distributions were compared using Akaike Information Criterion (AIC) values. Key results: Among the distributions that were considered, we found that times spent ruminating in both male and female sheep populations as well as idling in male sheep were best described by the skew exponential type 2 distribution. Grazing, walking and licking behaviours were best described by the Box-Cox t distribution. The distribution of time spent grazing was symmetrical and unimodal in males, and adequately modelled by a normal distribution, but the distribution in females had a prominent left skew. Also, we found that females typically grazed for a longer time than males. However, males spent more time ruminating than grazing. Conclusions: The time spent by the animal in each activity varied during the day. Within each population, the variation among animals in the time spent grazing was best described by a Box-Cox t distribution. Implications: This study has enhanced our understanding of grazing behaviour and will facilitate more appropriate analyses of the causes of variation among animals in grazing behaviour.
title: Sicherere Behandlung älterer Menschen durch evidenz-basierte Listen potentiell inadäquater Medikamente (PIM): ein neues methodisches Konzept zur Erstellung einer PIM-Liste
Creators: name: Klager, Elisabeth
name: Moussa, Mahmoud
name: Cichocki, Martin
name: Gomez-Pellin, Maria
name: Mann, Eva
name: Mathes, Tim
name: Pieper, Dawid
name: Thürmann, Petra A.
name: Mann, Nina K.
name: Rabady, Susanne
name: Keuerleber, Simon
name: Glöckner, Lena
name: Sönnichsen, Andreas C.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Medikamente wirken im Alter anders als bei jüngeren Menschen. Dies begünstigt unerwünschte Arzneimittelwirkungen. Für viele Wirkstoffe sind Nutzen und Risiken bei Älteren unklar, da diese oft in Zulassungsstudien nicht eingeschlossen werden. Viele[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Economic burden of caregivers: A scoping review protocol
Creators: name: Guertin, Jason Robert
name: Gilbert-Ouimet, Mahée
name: Bergeron, Frédéric
name: Dugas, Michèle
name: Stéfan, Théo
name: Carnovale, Valérie
name: Jalbert, Laura
name: Svyntozelska, Olha
name: Poirier, Andrée-Anne
name: LeBlanc, Annie
Publisher: name: Zenodo
Year: 2022
Subjects: Economic burden
Caregivers
Cost of illness
Health expenditure
Scoping review

description: Protocol for a scoping review on the methods and approaches used to assess the economic burden of caregivers
On the Riemann Hypothesis and other Brain Teasers
Creators: name: Smith, John
Publisher: name: figshare
Year: 2017
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics

description: Abstract In 1963, a game show called Lets Make A Deal began in the United States. On the show, the host - Monty Hall - would present contestants with the choice of 3 doors, behind only 1 of which was a car. A contestant would pick a door such as No. 1, and Monty, who knew what was behind the doors, would open another door, say No. 2, revealing a goat. Monty would then ask the contestant if they wanted to change their selection to door No. 3. It is widely accepted that the contestant should change doors on the basis that the chances of the car being behind door 3 are 2/3, whereas the chances of the car being behind door 1 are only 1/3. But by appeal to congruities that exist between this seemingly innocuous and simple problem and variety of deeper and less tractable problems, this Monty Hall is revealed as the tip of a great intellectual and iceberg.
title: Wege zu einer besseren Implementierung von digitalen Gesundheitsanwendungen in die Gesundheitsversorgung der GKV
Creators: name: Lantzsch, Hendrikje
name: Stephani, Victor
name: Panteli, Dimitra
name: Busse, Reinhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Digitale Gesundheitsanwendungen (DiGA) bezeichnen kooperative und/oder interaktive Anwendungen von modernen Informations- und Kommunikationstechnologien zur Verbesserung der Gesundheitsversorgung und Bevölkerungsgesundheit. Diese können sowohl eigenständig[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
On the Riemann Hypothesis and other Brain Teasers
Creators: name: Smith, John
Publisher: name: figshare
Year: 2017
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics

description: Abstract In 1963, a game show called Lets Make A Deal began in the United States. On the show, the host - Monty Hall - would present contestants with the choice of 3 doors, behind only 1 of which was a car. A contestant would pick a door such as No. 1, and Monty, who knew what was behind the doors, would open another door, say No. 2, revealing a goat. Monty would then ask the contestant if they wanted to change their selection to door No. 3. It is widely accepted that the contestant should change doors on the basis that the chances of the car being behind door 3 are 2/3, whereas the chances of the car being behind door 1 are only 1/3. But by appeal to congruities that exist between this seemingly innocuous and simple problem and variety of deeper and less tractable problems, and Monty Hall is revealed as the tip of a great intellectual and iceberg.
Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation
Creators: name: Glab, Jason
name: Puthalakath, Hamsa
name: Zhang, Shenpeng
name: Vinh, Antony
name: Drummond, Grant
name: Sobey, Christopher
name: De Silva, Michael
name: Kim, Hyun Ah
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Cellular apoptosis is a key pathological mechanism contributing to neuronal death following ischemic stroke. The pro-apoptotic Bcl-2 family protein, Bim, is an important regulator of apoptosis. In this study we investigated the effect of Bim expression on post-stroke functional outcomes, brain injury and inflammatory mechanisms. Wild type (WT) and Bim-deficient mice underwent 1-h middle cerebral artery occlusion (MCAO) followed by 23 h of reperfusion. At 24-h post-stroke, we assessed functional deficit, infarct volume, immune cell death, as well as the number of infiltrating immune cells in the brain and circulating immune cells. Bim deficiency did not affect infarct volume (P > 0.05), but resulted in less motor impairment (~ threefold greater latency to fall in hanging grip strength test, P < 0.05) and a lower median clinical score than WT mice (P < 0.05). Additionally following MCAO, Bim-deficient mice exhibited fewer myeloid cells (particularly neutrophils) in the ischemic brain hemisphere and less apoptosis of CD3+ T cells in the spleen and thymus compared with WT (all P < 0.05). After MCAO, Bim-deficient mice also tended to have more M2-polarised macrophages in the brain than WT mice. In sham-operated mice, we found that Bim deficiency resulted in greater numbers of circulating total CD45+ leukocytes, Ly6Clo+ monocytes and CD3+ T cells, although MCAO did not affect the number of circulating cells at 24 h in either genotype. Our findings suggest that Bim deficiency modulates post-stroke outcomes, including reductions in motor impairment, brain inflammation and systemic post-stroke leukocyte apoptosis. Bim could therefore serve as a potential therapeutic target for stroke.
An exploratory study of industry perspectives to inform undergraduate nutrition employability initiatives.
Creators: name: Croxford, Sharon
name: Stirling, Emma
name: McLeod, Susan
name: Biesiekierski, Jessica
name: Murray, Emily
name: Ng, Ashley
name: Bramley, Andrea
name: Forsyth, Adrienne
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 321099
subject: Nutrition and dietetics not elsewhere classified

description: Aim: The aim of this study was to explore nutrition professionals' perspectives of nutrition graduates' employability skills, and knowledge and skills required in the industry to understand gaps in undergraduate nutrition curriculum. Methods: Nutrition professionals (n = 26) across Australia were approached to participate in semi-structured interviews via telephone in 2018. Interviews were transcribed verbatim, data analysed using thematic analysis, and results interpreted and discussed. Results: Nine participants across six work environments completed interviews. Common work roles were identified in their diverse areas of practice: nutrition educators, food developers, team members, and business leaders. Nutrition professionals identified that, in addition to evidence-based discipline knowledge, key skills and knowledge needed for their roles were interpersonal communication, including writing and listening. Participants highlighted the need for employability skills to be embedded within curriculum with emphasis on professional skills, business skills and discipline-specific skills in communicating complex science messages to a range of audiences. Networking, and formal and informal work-integrated learning were viewed as important vehicles for developing required skills. Participants expected that universities develop curriculum to address gaps; however, reflection by the academic researchers suggested this should be a joint role. Conclusions: Early career planning, professional skill development, work experience and networking opportunities should enhance graduate employability.
Prefabricated contoured foot orthoses to reduce pain and increase physical activity in people with hip osteoarthritis: protocol for a randomised feasibility trial
Creators: name: King, Matthew
name: Kemp, Joanne
name: Hon, Ryan
name: Pizzari, Tania
name: Wong, Justin
name: Menz, Hylton
name: Taylor, Nicholas
name: Harms, Anton
name: McClelland, Jodie
name: Semciw, Adam
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 320223
subject: Rheumatology and arthritis

description: Introduction The aim of this randomised feasibility trial is to determine the feasibility of conducting an adequately powered randomised controlled trial (RCT) investigating the efficacy of prefabricated contoured foot orthoses in people with hip osteoarthritis (OA). The secondary aims of the trial are to compare the effect of prefabricated contoured foot orthoses to a flat shoe insert comparator on outcomes of hip-related pain, physical activity and quality of life. We hypothesise that the demand, implementation, acceptability and practicality of foot orthoses as a treatment option for people with hip OA will be deemed feasible, informing the development of an adequately powered RCT to evaluate the efficacy and long term outcomes. Methods and analysis We will recruit 28 people with hip OA who will be randomised to receive either prefabricated contoured foot orthoses or flat shoe inserts to use for a 6-week period. Both groups will receive standardised education on hip OA and physical activity. The study's primary outcome is the feasibility domains of demand, implementation, acceptability and practicality. The secondary outcomes include the change in Hip Osteoarthritis Outcome Score-12, Patient Health Questionnaire-9, Brief Fear of Movement Scale for OA, Physical activity accelerometry and the Physical Activity Questionnaire-short form. Descriptive statistics will be used to describe feasibility outcomes with limited efficacy analysis used for the secondary outcomes. Linear mixed models will be used to analyse between-group differences at 6 weeks, with baseline values used as covariates, treatment allocation as a fixed factor and participant as a random factor. Ethics and dissemination This trial has been approved by the La Trobe University Human Research Ethics Committee (HEC20427), St. Vincent's Hospital Melbourne, Human Research Ethics Committee (HREC 266/20) and Northern Health Research Governance (NH-2021-292862). The results will be disseminated via a peer-reviewed journal and presented at international conferences. Trial registration number NCT05138380.
A marine isotope stage 11 coastal Acheulian workshop with associated wood at Amanzi Springs Area 1, South Africa
Creators: name: Herries, Andrew
name: Arnold, LJ
name: Boschian, G
name: Blackwood, Alexander
name: Wilson, Coen
name: Mallett, Tom
name: Armstrong, Brian
name: Demuro, M
name: Petchey, F
name: Meredith-Williams, Matthew
name: Penzo-Kajewski, Paul
name: Caruana, MV
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 430199
subject: Archaeology not elsewhere classified
classificationCode: 430102
subject: Archaeology of Asia, Africa and the Americas
classificationCode: 370599
subject: Geology not elsewhere classified
classificationCode: 370999
subject: Physical geography and environmental geoscience not elsewhere classified

description: Amanzi Springs is a series of inactive thermal springs located near Kariega in the Eastern Cape of South Africa. Excavations in the 1960s exposed rare, stratified Acheulian-bearing deposits that were not further investigated over the next 50 years. Reanalysis of the site and its legacy collection has led to a redefined stratigraphic context for the archaeology, a confirmed direct association between Acheulian artefacts and wood, as well as the first reliable age estimates for the site. Thermally transferred optically stimulated luminescence and post-infrared infrared stimulated luminescence dating indicates that the Acheulian deposits from the Amanzi Springs Area 1 spring eye formed during Marine Isotope Stage (MIS) 11 at ~ 404-390 ka. At this time, higher sea levels of ~13-14m would have placed Amanzi Springs around 7 km from a ria that would have formed along what is today the Swartkops River, and which likely led to spring reactivation. This makes the Amanzi Springs Area 1 assemblage an unusual occurrence of a verified late occurring, seaward, open-air Acheulian occupation. The Acheulian levels do not contain any Middle Stone Age (MSA) elements such as blades and points that have been documented in the interior of South Africa at this time. However, a small number of stone tools from the upper layers of the artefact zone, and originally thought of as intrusive, have been dated to ~190 ka, at the transition between MIS 7 to 6, and represent the first potential MSA identified at the site.
LiBRI Journal - “A Splendid Isolation?” The Rise of a Concept in Victorian Identity
Creators: name: Vișoiu, Mihai
Publisher: name: figshare
Year: 2017
Subjects: subject: 200525 Literary Theory
subject: FOS: Languages and literature

description: Abstract
The last decade of the nineteenth century coincides with the appearance of a new phrase in the Victorian press, that of a “splendid isolation”. In 1894, after prime-minister Rosebery’s speech in Cows regarding the possibility of an anglo-german alliance, a real media scandal broke out between the British newspapers Standard and The Times and the German publication Hamburghischer Correspondent. What was the cause of this ‘conflict’? A debate regarding the position which these two great states held in the European balance of power. Initially perceived as an insult, the term `isolation` is more and more frequent in Victorian thought, from political discourses and parliamentary debates to Sunday newspapers. At the same time, British foreign policy stirs more and more concerns in the minds of the great statesmen of Westminster, a fact determined to a great degree by the overuse of this certain phrase. Extremely interesting is also the evolution of this concept in the perception of the public. If in 1894, `isolation` meant `a dangerous position`, over the course of the next few years, this way of international conduct becomes ‘a time-honoured tradition’. In 1896 the epithet ‘splendid’ joins ‘isolation’, and in the next period ‘the policy of isolation’ is consecrated the `official strategy` of British foreign policy in the Victorian age.
For more, check the following webpage:https://www.edusoft.ro/brain/index.php/libri/article/view/587
title: Cochrane systematic reviews for the use of international guideline information to improve worldwide cancer care: experience report on how to inform the WHO Essential medicines list
Creators: name: Piechotta, Vanessa
name: Goldkuhle, Marius
name: Skoetz, Nicole
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Essential medicines aim to satisfy the priority health needs of a population. They are meant to be safe and effective, as well as universally available and affordable. The World Health Organizations Essential Medicines List (EML) provides an evidence-based model upon[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Conflict of Interest Policies at German medical schools – A long way to go
Creators: name: Grabitz, Peter
name: Friedmann, Zoé
name: Gepp, Sophie
name: Hess, Leonard
name: Specht, Lisa
name: Struck, Maja
name: Tragert, Sophie
name: Walther, Tobias
name: Klemperer, David
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Most medical students are in contact with the pharmaceutical or medical device industry during their studies. Medical schools play an important role in protecting students from undue commercial influence and educating them about pharmaceutical marketing practices. [for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment
Creators: name: Rajeev, Vismitha
name: Fann, DY
name: Dinh, Quynh Nhu
name: Kim, Hyun Ah
name: De Silva, Michael
name: Jo, DG
name: Drummond, Grant
name: Sobey, Christopher
name: Lai, MKP
name: Chen, CLH
name: Arumugam, Thiruma
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Background – Chronic cerebral hypoperfusion (CCH) is an important pathophysiological mechanism of vascular cognitive impairment (VCI). The heterogeneous effects of CCH complicate establishing single target therapies against VCI and its more severe form, vascular dementia (VaD). Intermittent fasting (IF) has multiple targets and is neuroprotective across a range of disease conditions including stroke, but its effects against CCH-induced neurovascular pathologies remain to be elucidated. We therefore assessed the effect of IF against CCH-associated neurovascular pathologies and investigated its underlying mechanisms. Methods – Male C57BL/6NTac mice were subjected to either ad libitum feeding (AL) or IF (16 hours of fasting per day) for 4 months. In both groups, CCH was experimentally induced by the bilateral common carotid artery stenosis (BCAS) method. Sham operated groups were used as controls. Measures of leaky microvessels, blood-brain barrier (BBB) permeability, protein expression of tight junctions, extracellular matrix components and white matter changes were determined to investigate the effect of IF against CCH-induced neurovascular pathologies. Results – IF alleviated CCH-induced neurovascular pathologies by reducing the number of leaky microvessels, BBB breakdown and loss of tight junctional proteins. In addition, IF mitigated the severity of white matter lesions, and maintained myelin basic protein levels, while concurrently reducing hippocampal neuronal cell death. Furthermore, IF reduced the CCH-induced increase in levels of matrix metalloproteinase (MMP)-2 and its upstream activator MT1-MMP, which are involved in the breakdown of the extracellular matrix that is a core component of the BBB. Additionally, we observed that IF reduced CCH-induced increase in the oxidative stress marker malondialdehyde, and increased antioxidant markers glutathione and superoxide dismutase. Overall, our data suggest that IF attenuates neurovascular damage, metalloproteinase and oxidative stress-associated pathways, and cell death in the brain following CCH in a mouse model of VCI. Conclusion – Although IF has yet to be assessed in human patients with VaD, our data suggest that IF may be an effective means of preventing the onset or suppressing the development of neurovascular pathologies in VCI and VaD.
title: Interessenkonflikte im Gesundheitswesen: Welche sekundären Effekte kann eine Offenlegung von Interessenkonflikten haben?
Creators: name: Stoll, Marlene
name: Egloff, Boris
name: Lieb, Klaus
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Das Patientenwohl wird häufig als das primäre Interesse eines Arztes oder einer Ärztin angesehen. Im Gesundheitssystem gibt es jedoch viele Faktoren, die zu sekundären Interessen führen. Diese Interessenkonstellationen können ein Risiko darstellen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Note su infiniti flessi in chianino: un approccio cartografico
Creators: name: Samo, Giuseppe
name: Canuti, Massimiliano
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

In this article, we investigate a morpho-syntactic phenomenon in Chianino similar to the inflected infinitive discussed for Romance. Chianino is an Italo-Romance variety spoken in the southeast of the province of Siena. The analysed structures involve pairs of inflected verbs merged together. The candidates for the higher verb of the pair are (i) the root of the modal dové ‘must’ and (ii) the subjunctive form of avé ‘to have’. The second element of the pair can only be a non-suppletive inflected infinitive form of the verb èsse ‘to be’, as in the cases of the second person singular dev-ess-i ‘you must be’ and abbi-ess-i ‘you have to be’ (meaning: ‘you should be’). From a pragmatic point of view, the double inflected forms avé + èsse can only have epistemic readings, while dové + èsse can also have a jussive connotation. After having briefly introduced the variety under investigation, we will discuss observational and introspective data. We will then proceed to a formal analysis. Adopting a cartographic approach, we consider the second element of the pair as a head located in a dedicated functional projection within the syntactic architecture.

description: Annali di Ca’ Foscari. Serie occidentale
title: Currently available checklists and tools for the assessment of clinical trial feasibility – a scoping review
Creators: name: Gloy, Viktoria Luise
name: Speich, Benjamin
name: Griessbach, Alexandra
name: Fabbro, Thomas
name: Taji Heravi, Ala
name: Pauli Magnus, Christiane
name: Briel, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: One out of four clinical trials are not completed as planned, mostly because of poor recruitment. This constitutes a considerable waste of research resources. Tools or checklists that can be used by researchers, funding agencies or research ethics committees to assess[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Acceleration of diagnostic research: Is there a potential for seamless designs?
Creators: name: Vach, Werner
name: Bibiza-Freiwald, Eric
name: Gerke, Oke
name: Friede, Tim
name: Zapf, Antonia
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: New diagnostic tests to identify a well-established disease state have to undergo a series of scientific studies from test construction until finally demonstrating a societal impact. Traditionally, these studies are performed with substantial time gaps in between,[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Lean Evidence Management – Applicability and Feasibility of an Industrial Management Principle in Clinical Research
Creators: name: Diener, Markus K.
name: Hüttner, Felix J.
name: Knebel, Phillip
name: Mihaljevic, André L.
name: Probst, Pasca
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Clinical research is faced with the identical economic pressure as the whole medical system. The current organization of clinical research lacks of centralized prioritization of urgent and relevant scientific research questions. As a result, evidence is produced today[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Comparison of Planned and Actual costs related to Investigational Medical Products in Clinical Trials
Creators: name: Taji Heravi, Ala
name: Henn, Anne
name: Deuster, Stefanie
name: Gloy, Victoria
name: Mitter, Vera
name: Briel, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Conducting high quality randomized clinical trials (RCTs) is challenging and costly. Particularly investigator-initiated RCTs (IICTs) are often not completed as planned. The intervention under investigation is obviously an essential component of a clinical trial contributing[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Patient experiences of codesigned rehabilitation interventions in hospitals: a rapid review
Creators: name: McKercher, Jonathan
name: Slade, Susan
name: Jazayeri, JA
name: Hodge, Anita
name: Knight, Matthew
name: Green, J
name: Woods, Jeffrey
name: Thwaites, Claire
name: Morris, Meg
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 420109
subject: Rehabilitation
classificationCode: 420305
subject: Health and community services

description: Background Codesign strengthens partnerships between healthcare workers and patients. It also facilitates collaborations supporting the development, design and delivery of healthcare services. Prior rehabilitation reviews have focused mainly on the clinical and organisational outcomes of codesign with less focus on the lived experience of rehabilitation patients. Objective To explore patient experiences of codesigned hospital rehabilitation interventions. Design Rapid review and evidence synthesis of the literature. Data sources CINAHL, MEDLINE, Embase and Cochrane were searched from 1 January 2000 to 25 April 2022. Study selection Studies reporting patient experiences of codesigned rehabilitation interventions in hospitals. Results 4156 studies were screened, and 38 full-text studies were assessed for eligibility. Seven studies were included in the final rapid review. Five out of the seven studies involved neurological rehabilitation. All eligible studies used qualitative research methods. The main barriers to codesign were related to staffing and dedicated time allocated to face-to-face patient-therapist interactions. High-quality relationships between patients and their therapists were a facilitator of codesign. Thematic synthesis revealed that codesigned rehabilitation interventions can enable a meaningful experience for patients and facilitate tailoring of treatments to align with individual needs. Personalised rehabilitation increases patient involvement in rehabilitation planning, delivery and decision-making. It also promotes positive feelings of empowerment and hope. Conclusion This rapid review supports the implementation of codesigned rehabilitation interventions to improve patient experiences in hospitals. PROSPERO registration number CRD42021264547.
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00040
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00040, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00040, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
title: Lettre de Jacques Leibowitch à Willy Rozenbaum (Hôpital Rothschild)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113393093
title: Longitudinal evaluation of the reporting quality of clinical trial protocols – evidence for improvement? The Adherence to SPIrit REcommendations (ASPIRE) Study
Creators: name: Gryaznov, Dmitry
name: Kassenda, Benjamin
name: von Elm, Erik
name: von Niederhäusern, Belinda
name: Speich, Benjamin
name: Hemkens, Lars  G.
name: Schandelmaier, Stefan
name: Ruiz, Elena  Ojeda
name: Mc Cord, Kimberly Alba
name: Saccilotto, Ramon
name: Tomonaga, Yuki
name: Amstutz, Alain
name: Briel, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: We investigated the reporting quality of randomized clinical trial (RCT) protocols approved by Swiss research ethics committees (RECs), before the introduction of the Human Research Act in Switzerland in 2014 and the publication of the SPIRIT guidelines in 2013, and[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
LiBRI Journal - The Sacred In Literature And Arts
Creators: name: Onofrei, Paula
Publisher: name: figshare
Year: 2017
Subjects: subject: 200204 Cultural Theory
subject: FOS: Other humanities

description: Abstract
The dimension of the sacred in contemporary literature and arts is a challenge which has managed to captivate us to such an extent that we have decided to analyze it systematically, starting from the book of Adrian Stoleriu. As far as the literary part is concerned, we have chosen the author of the first Romanian catechetical realistic novel, Professor Cornel Constantin Ciomâzgă, with his first two books, “Lucrarea” (“The Work”) and the one we have translated, “Se întorc morţii acasă” (“The Dead Are Coming Back Home”). Regarding the part related to arts, we have identified the motif of the sacred in works of art that belong to different artistic movements, and we will also refer to the vision of the contemporary group “Prologue”, thus offering an interdisciplinary approach of the topic.
For more, check the following link:https://www.edusoft.ro/brain/index.php/libri/article/view/642
“Much better than I thought it was going to be”: Telehealth delivered group-based education and exercise was perceived as acceptable among people with knee osteoarthritis
Creators: name: Ezzat, Allison
name: Bell, Emily
name: Kemp, Joanne
name: O'Halloran, Paul
name: Russell, T
name: Wallis, J
name: Barton, Christian
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified

description: OBJECTIVE: To understand patient perceived acceptability of participating in a telehealth delivered group-based education and exercise-therapy program for knee osteoarthritis. DESIGN: This qualitative study involved semi-structured, one-on-one interviews with knee osteoarthritis patients who have completed the Good Living with osteoArthritis from Denmark (GLA:D®) program via telehealth or in-person. Interviews were recorded, transcribed verbatim, coded, and analysed using an inductive content analysis approach, focusing on themes related to telehealth. RESULTS: Nineteen participants [12 (63%) female, mean aged 62 years, range 49-72 years] were included. Eleven (58%) received GLA:D® via telehealth and 8 (42%) attended in-person sessions. Two overarching themes (6 sub-themes) related to telehealth perceived acceptability were identified: 1) Perceptions of telehealth acceptability was highly influenced by exposure. Individuals who had received telehealth considered it easy, convenient, and flexible, whereas telehealth was perceived to be inferior and misunderstood by those without exposure. 2) Telehealth participants reported similar program benefits to in-person participants, including reduced fear of pain and joint damage, changed beliefs in value of exercise, and stated improvements in pain and function. CONCLUSIONS: Telehealth delivery of group-based education and exercise-therapy for knee osteoarthritis was acceptable for people who had experienced it and provides similar benefits as in-person care for pain and beliefs about the safety and value of exercise. Wider implementation of telehealth group-based education and exercise-therapy may improve access to high value care for people with knee osteoarthritis.
title: National and international networks to improve clinical research methodology
Creators: name: Briel, Matthias
name: Treweek, Shaun
name: Hemkens, Lars
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: High quality clinical research is a pre-requisite for high quality evidence to best inform decision making in clinical practice and health policy. However, clinical research faces many challenges and the evidence base to guide the design and conduct of clinical studies,[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin