cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adaptive Real-Time Decomposition of Electromyogram During Sustained Muscle Activation: A Simulation Study
Creators: name: Hu, Xiaogang
name: Zheng, Yang
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2022

description: OBJECTIVE: Real-time decomposition of electromyogram (EMG) into constituent motor unit (MU) activity has shown promising applications in neurophysiology and human-machine interactions. Existing decomposition methods could not accommodate stochastic variations in EMG signals such as drifts of action potential amplitudes and MU recruitment-derecruitment (rotation) patterns during long-term recordings. The objective of this study was to develop an adaptive real-time decomposition approach suitable for prolonged muscle activation. METHODS: We developed a parallel-double-thread computation algorithm. The backend thread initiated and periodically refined and updated the MU information (separation matrix) using independent component analysis and convolution kernel compensation. The frontend thread performed the real-time decomposition. We evaluated our algorithm on synthesized high-density EMG signals, in which MUs were recruited-derecruited sporadically and MU action potentials amplitude drifted over time. Different signal-to-noise levels were also simulated. RESULTS: Compared with the decomposition without the adaptive processes, periodically fine-tuned and updated separation matrix increased identifiable MU number by 3-4 fold over 30-minute of signals. The increased MU number was more prominent at higher signal-to-noise ratios. The decomposition accuracy also increased by up to 10% with greater improvement observed at higher muscle contraction levels. CONCLUSION: The adaptive algorithm can maintain the decomposition performance over time, allows us to continuously track the same MUs during sustained activation, and, at the same time, can add newly recruited MU information to existing separation matrix. SIGNIFICANCE: Our approach showed robust performance over time, which has the potential to longitudinally evaluate MU firing and recruitment properties and improve neural decoding performance for neural-machine interactions.
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
Creators: name: Nimmala, Kirti R
name: Brown, Hannon L
name: Collins, John A
name: Shine, Jacqueline
name: Copp, Michaela E
name: Diekman, Brian O
name: Hansen, Oliver B
name: Chubinskaya, Susan
name: Loeser, Richard F
Publisher: name: Impact Journals, LLC
Year: 2023

description: While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. The purpose of this study was to determine whether a decline in DNA repair efficiency is one explanation for the accumulation of DNA damage with age, and to quantify the improvement in repair with activation of Sirtuin 6 (SIRT6). After acute damage with irradiation, DNA repair was shown to be more efficient in chondrocytes from young (â‰¤45 years old) as compared to middle-aged (50-65 years old) or older (>70 years old) cadaveric donors. Activation of SIRT6 with MDL-800 improved the repair efficiency, while inhibition with EX-527 reduced the rate of repair and increased the percentage of cells that retain high levels of damage. In addition to affecting repair after acute damage, treating chondrocytes from older donors with MDL-800 for 48 hours significantly reduced the amount of baseline DNA damage. Chondrocytes isolated from the knees of mice between 4 months and 22 months of age revealed both an increase in DNA damage with aging, and a decrease in DNA damage following MDL-800 treatment. Lastly, treating murine cartilage explants with MDL-800 lowered the percentage of chondrocytes with high p16 promoter activity, which supports the concept that using SIRT6 activation to maintain low levels of DNA damage may prevent the initiation of senescence.
Corticotropin Releasing Factor Type 1 and 2 Receptor Signaling in the Medial Prefrontal Cortex Modulates Binge-Like Ethanol Consumption in C57BL/6J Mice
Creators: name: Perez-Heydrich, Carlos A.
name: Thiele, Todd E.
name: Robinson, Stacey L.
Publisher: name: MDPI
Year: 2019

description: Corticotropin releasing factor (CRF) signaling via limbic CRF1 and 2 receptors (CRF1R and CRF2R, respectively) is known to modulate binge-like ethanol consumption in rodents. Though CRF signaling in the medial prefrontal cortex (mPFC) has been shown to modulate anxiety-like behavior and ethanol seeking, its role in binge ethanol intake is unknown. Here, we used "drinking-in-the-dark" (DID) procedures in male and female C57BL/6J mice to address this gap in the literature. First, the role of CRF1R and CRF2R signaling in the mPFC on ethanol consumption was evaluated through site-directed pharmacology. Next, we evaluated if CRF1R antagonist reduction of binge-intake was modulated in part through CRF2R activation by co-administration of a CRF1R and CRF2R antagonist. Intra-mPFC inhibition of CRF1R and activation of CRF2R resulted in decreased binge-like ethanol intake. Further, the inhibitory effect of the CRF1R antagonist was attenuated by co-administration of a CRF2R antagonist. We provide novel evidence that (1) inhibition of CRF1R or activation of CRF2R in the mPFC reduces binge-like ethanol intake; and (2) the effect of CRF1R antagonism may be mediated via enhanced CRF2R activation. These observations provide the first direct behavioral pharmacological evidence that CRF receptor activity in the mPFC modulates binge-like ethanol consumption.
Paracratomorphus Zaragoza-Caballero 2013
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Paracratomorphus

description: Genus Paracratomorphus Zaragoza-Caballero, 2013
MTZ: SO
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Development and implementation of robust large deformation and contact mechanics capabilities in process modelling of composites
Creators: name: Osooly, Amir
Publisher: name: University of British Columbia
Year: 2008

description: Autoclave processing of large scale, one-piece structural parts made of carbon fiber-reinforced polymer composite materials is the key to decreasing manufacturing costs while at the same time increasing quality. Nonetheless, even in manufacturing simple flat parts, residual strains and stresses are unavoidable. For structural design purposes and to aid in the assembly procedures, it is desirable to have proven numerical tools that can be used to predict these residual geometrical and material properties in advance, thus avoid the costly experimental trial and error methods. A 2-D finite element-based code, COMPRO, has previously been developed in-house for predicting autoclave process-induced deformations and residual stresses in composite parts undergoing an entire cure cycle. To simulate the tool-part interaction, an important source of residual deformations/stresses, COMPRO used a non-zero thickness elastic shear layer as its only interface option. Moreover, the code did not account for the large deformations and strains and the resulting nonlinear effects that can arise during the early stages of the cure cycle when the material is rather compliant. In the present work, a contact surface employing a penalty method formulation is introduced at the tool-part interface. Its material-dependent parameters are a function of temperature, degree of cure, pressure and so forth. This makes the stick-slip condition plus separation between the part and the tool possible. The large displacements/rotations and large shear strains that develop at the early stages of the cure cycle when the resin has a very low elastic modulus provided the impetus to include a large strain/deformation option in COMPRO. A new “co-rotational stress formulation” was developed and found to provide a robust method for numerical treatment of very large deformation/strain problems involving anisotropic materials of interest here. Several verification and validation examples are used to calibrate the contact interface parameters and to demonstrate the correctness of implementation and the accuracy of the proposed method. A number of comparisons are made with exact solutions, other methods, other experiments and the same models in other commercial codes. Finally, several interesting cases are examined to explore the results of COMPRO predictions with the added options.
Distinct and Overlapping Patterns of Acute Ethanol-Induced C-Fos Activation in Two Inbred Replicate Lines of Mice Selected for Drinking to High Blood Ethanol Concentrations
Creators: name: Thiele, Todd E.
name: Companion, Michel A.
name: Navarro, Montserrat
name: Dornellas, Ana Paula S.
name: Bendrath, Sophie C.
name: Brewton, HonoreÃ© W.
name: Robinson, Stacey L.
name: Thomas, Rhiannon D.
name: Houck, Christa A.
name: Burnham, Nathan W.
name: Luhn, Kendall L.
Publisher: name: MDPI
Year: 2020

description: The inbred high drinking in the dark (iHDID1 and iHDID2) strains are two replicate lines bred from the parent HS/Npt (HS) line for achieving binge levels of blood ethanol concentration (â‰¥80 mg/dL BEC) in a four-hour period. In this work, we sought to evaluate differences in baseline and ethanol-induced c-Fos activation between the HS, iHDID1, and iHDID2 genetic lines in brain regions known to process the aversive properties of ethanol. METHODS: Male and female HS, iHDID1, and iHDID2 mice underwent an IP saline 2 3 g/kg ethanol injection. Brain sections were then stained for c-Fos expression in the basolateral/central amygdala (BLA/CeA), bed nucleus of the stria terminals (BNST), A2, locus coeruleus (LC), parabrachial nucleus (PBN), lateral/medial habenula (LHb/MHb), paraventricular nucleus of the thalamus (PVT), periaqueductal gray (PAG), Edinger-Westphal nuclei (EW), and rostromedial tegmental nucleus (RMTg). RESULTS: The iHDID1 and iHDID2 lines showed similar and distinct patterns of regional c-Fos; however, in no region did the two both significantly differ from the HS line together. CONCLUSIONS: These data lend further support to altered baseline or ethanol-induced activation in brain regions associated with processing the aversive properties of ethanol in the iHDID1 and iHDID2 genetic lines.
Analysis of multi-electron, multi-step homogeneous catalysis by rotating disc electrode voltammetry: theory, application, and obstacles
Creators: name: Dempsey, Jillian L.
name: Griffith, Boyce E.
name: Lee, Katherine J.
name: Qadeer, Saad
name: Lodaya, Kunal M.
name: Gruninger, Cole T.
Publisher: name: Royal Society of Chemistry (RSC)
Year: 2020

description: Rotating disc electrode (RDE) voltammetry has been widely adopted for the study of heterogenized molecular electrocatalysts for multi-step fuel-forming reactions but this tool has never been comprehensively applied to their homogeneous analogues. Here, the utility and limitations of RDE techniques for mechanistic and kinetic analysis of homogeneous molecular catalysts that mediate multi-electron, multi-substrate redox transformations are explored. Using the ECEC' reaction mechanism as a case study, two theoretical models are derived based on the Nernst diffusion layer model and the Hale transformation. Current-potential curves generated by these computational strategies are compared under a variety of limiting conditions to identify conditions under which the more minimalist Nernst Diffusion Layer approach can be applied. Based on this theoretical treatment, strategies for extracting kinetic information from the plateau current and the foot of the catalytic wave are derived. RDEV is applied to a cobaloxime hydrogen evolution reaction (HER) catalyst under non-aqueous conditions in order to experimentally validate this theoretical framework and explore the feasibility of RDE as a tool for studying homogeneous catalysts. Crucially, analysis of the foot-of-the-wave via this theoretical framework provides rate constants for elementary reaction steps that agree with those extracted from stationary voltammetric methods, supporting the application of RDE to study homogeneous fuel-forming catalysts. Finally, obstacles encountered during the kinetic analysis of cobaloxime, along with the voltammetric signatures used to diagnose this reactivity, are discussed with the goal of guiding groups working to improve RDE set-ups and help researchers avoid misinterpretation of RDE data.
Additional file 1: of A method for measuring individual research productivity in hospitals: development and feasibility
Creators: name: Caminiti, Caterina
name: Iezzi, Elisa
name: Ghetti, Caterina
name: Angelis, Gianluigi Deâ
name: Ferrari, Carlo
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Questionnaire to record participation in resarch activities. (DOC 32 kb)
CLAMS: A Cluster Ambiguity Measure for Estimating Perceptual Variability in Visual Clustering
Creators: name: Jeon, Hyeon
name: Rosen, Paul
name: Seo, Jinwook
name: Quadri, Ghulam Jilani
name: Szafir, Danielle Albers
name: Lee, Hyunwook
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2023

description: Visual clustering is a common perceptual task in scatterplots that supports diverse analytics tasks (e.g., cluster identification). However, even with the same scatterplot, the ways of perceiving clusters (i.e., conducting visual clustering) can differ due to the differences among individuals and ambiguous cluster boundaries. Although such perceptual variability casts doubt on the reliability of data analysis based on visual clustering, we lack a systematic way to efficiently assess this variability. In this research, we study perceptual variability in conducting visual clustering, which we call Cluster Ambiguity. To this end, we introduce CLAMS, a data-driven visual quality measure for automatically predicting cluster ambiguity in monochrome scatterplots. We first conduct a qualitative study to identify key factors that affect the visual separation of clusters (e.g., proximity or size difference between clusters). Based on study findings, we deploy a regression module that estimates the human-judged separability of two clusters. Then, CLAMS predicts cluster ambiguity by analyzing the aggregated results of all pairwise separability between clusters that are generated by the module. CLAMS outperforms widely-used clustering techniques in predicting ground truth cluster ambiguity. Meanwhile, CLAMS exhibits performance on par with human annotators. We conclude our work by presenting two applications for optimizing and benchmarking data mining techniques using CLAMS. The interactive demo of CLAMS is available at clusterambiguity.dev.
title: R/V SHINSEI MARU Cruise report KS-24-17
Creators: name: Takahashi, Kazutaka
Publisher: name: JAMSTEC
Year: 2024
Subjects: subject: Cruise report
subject: R/V SHINSEI MARU
subject: oceans

description: [CRUISE REPORT]
 This document is a preliminary report of KS-24-17 on R/V SHINSEI MARU from 2024-08-29 to 2024-09-11.
Concurrent and Continuous Prediction of Finger Kinetics and Kinematics via Motoneuron Activities
Creators: name: Kamper, Derek G.
name: Roy, Rinku
name: Hu, Xiaogang
name: Zheng, Yang
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2023

description: OBJECTIVE: Robust neural decoding of intended motor output is crucial to enable intuitive control of assistive devices, such as robotic hands, to perform daily tasks. Few existing neural decoders can predict kinetic and kinematic variables simultaneously. The current study developed a continuous neural decoding approach that can concurrently predict fingertip forces and joint angles of multiple fingers. METHODS: We obtained motoneuron firing activities by decomposing high-density electromyogram (HD EMG) signals of the extrinsic finger muscles. The identified motoneurons were first grouped and then refined specific to each finger (index or middle) and task (finger force and dynamic movement) combination. The refined motoneuron groups (separate matrix) were then applied directly to new EMG data in real-time involving both finger force and dynamic movement tasks produced by both fingers. EMG-amplitude-based prediction was also performed as a comparison. RESULTS: We found that the newly developed decoding approach outperformed the EMG-amplitude method for both finger force and joint angle estimations with a lower prediction error (Force: 3.47±0.43 vs 6.64±0.69% MVC, Joint Angle: 5.40±0.50° vs 12.8±0.65°) and a higher correlation (Force: 0.75±0.02 vs 0.66±0.05, Joint Angle: 0.94±0.01 vs 0.5±0.05) between the estimated and recorded motor output. The performance was also consistent for both fingers. CONCLUSION: The developed neural decoding algorithm allowed us to accurately and concurrently predict finger forces and joint angles of multiple fingers in real-time. SIGNIFICANCE: Our approach can enable intuitive interactions with assistive robotic hands, and allow the performance of dexterous hand skills involving both force control tasks and dynamic movement control tasks.
Paracratomorphus reyesi Zaragoza-Caballero 2013
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Paracratomorphus
Paracratomorphus reyesi

description: Paracratomorphus reyesi Zaragoza-Caballero, 2013
MEXICO: NL Endemic
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Deeply Learned Generalized Linear Models with Missing Data
Creators: name: Ibrahim, Joseph G.
name: Oliva, Junier B.
name: Rashid, Naim U.
name: Lim, David K.
Publisher: name: Taylor & Francis
Year: 2023

description: Deep Learning (DL) methods have dramatically increased in popularity in recent years, with significant growth in their application to various supervised learning problems. However, the greater prevalence and complexity of missing data in such datasets present significant challenges for DL methods. Here, we provide a formal treatment of missing data in the context of deeply learned generalized linear models, a supervised DL architecture for regression and classification problems. We propose a new architecture, dlglm, that is one of the first to be able to flexibly account for both ignorable and non-ignorable patterns of missingness in input features and response at training time. We demonstrate through statistical simulation that our method outperforms existing approaches for supervised learning tasks in the presence of missing not at random (MNAR) missingness. We conclude with a case study of the Bank Marketing dataset from the UCI Machine Learning Repository, in which we predict whether clients subscribed to a product based on phone survey data. Supplementary materials for this article are available online.
Additional file 1: Figure S1. of
                     Drosophila innate immunity: regional and functional specialization of prophenoloxidases
Creators: name: Dudzic, Jan
name: Kondo, Shu
name: Ueda, Ryu
name: Bergman, Casey
name: Lemaitre, Bruno
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: PPO3 does not contribute to hemolymph PO activity. Hemolymph PO activity of unchallenged larvae was monitored with an L-DOPA assay. Spontaneous PO activity is not affected in PPO3 1 mutant larvae compared to wild-type larvae. The hemolymph of wandering larvae was collected and examined for PO activity by transferring L-DOPA to dopachrome. The hemolymph of PPO1,2,3 mutant larvae was used as a negative control. Differences between PPO3 1 and the w 1118 wild-type control do not reach statistical significance. Data were analyzed by two-way ANOVA with Tukey correction. Values represent the mean ± standard error of the mean of three independent experiments. OD optical density (PDF 20 kb)
Environmental Effects on the Performance of Small-Molecule Organic Thin-Film Transistors
Creators: name: McNeil, L.E.
name: Jagoo, Zafrullah
Publisher: name: Wiley
Year: 2024

description: Electrical measurements are performed on a bottom-gate bottom-contact organic thin-film transistor with 2,8-difluoro-5,11-bis(triethylsilylethynyl) anthradithiophene (diF-TES ADT) (diF-TES ADT) as the active layer, varying the relative humidity of the environment surrounding the transistor. The results strongly indicate that water negatively impacts the electrical performance of the transistor and that the ingress of water is dynamic provided that the organic semiconductor layer is not encapsulated. It is found that the change can be reversed and the performance restored by removing the source of water. The drain current and threshold voltage of the transistor varied linearly when the relative humidity is changed from 35% to 7%, suggesting that the transistor can be used as a humidity sensor.
Pyractomena Melsheimer 1846
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena

description: Genus Pyractomena Melsheimer, 1846
NAR: TM; MTZ: SO, TV, CS; NTR: BB, VE, YU
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Additional file 2: of Evidence map of studies evaluating methods for conducting, interpreting and reporting overviews of systematic reviews of interventions: rationale and design
Creators: name: Lunny, Carole
name: Brennan, Sue
name: McDonald, Steve
name: McKenzie, Joanne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Search strategies. The search strategies that will be used to identify eligible studies. (DOC 24 kb)
Impact resistance of high strength fiber reinforced concrete
Creators: name: Zhang, Lihe
Publisher: name: University of British Columbia
Year: 2008

description: Concrete structures may be subjected to dynamic loading during their service life. Understanding the dynamic properties of concrete structures is becoming critical because of the increased concern about the dynamic loading of both civilian and military structures, and especially, the recent increase in terrorist attacks on structures. Fiber reinforced concrete (FRC) is known to exhibit superior performance in its post-peak energy absorption capacity, (i.e., toughness) under flexural and tensile loading. However, the behavior of fiber reinforced concrete under compressive impact has not previously been investigated. In the present research, the response of fiber reinforced concrete was investigated over the full strain rate regime, from static loading to high strain rate loading, and finally to impact loading. The compressive toughness of FRC under static loading was studied using an existing Japanese standard (JSCE SF-5). Then, a test method for FRC under compressive impact loading was developed, involving the use of a high speed video camera system to measure the deformation of FRC cylinders under compressive impact. The strain rate sensitivity of FRC in both flexure and compression was also fully investigated. FRC was found to have higher strengths under impact loading (both flexural and compressive) than under static loading. The compressive toughness under impact loading increased due to the high peak load and the high strain capacity. FRC under flexural impact loading showed a greater strength improvement than under static flexure. FRC displays a much higher Dynamic Improvement Factor (DIF) under flexural impact than under compressive impact. It gave an overall higher performance under impact than under static loading. It also exhibited a higher strain rate sensitivity than plain concrete in both compression and flexure. Damage analysis, in terms of loss of strain energy, was carried out based on damage mechanics principles. Damage was found to increase with increasing strain rate. A new constitutive model was proposed to account for the relationship between DIF (Comp) and strain rate and the data derived from the model were found to be consistent with the experimental results.
Pyractomena angulata
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena
Pyractomena angulata

description: Pyractomena angulata (Say, 1825)
Canada; USA; MEXICO: MO, NL, PU, SL, TM, VE
= Lampyris angulata Say, 1825
= Pyractomena flavocincta LeConte, 1852
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Finger Force Estimation Using Motor Unit Discharges Across Forearm Postures
Creators: name: Rubin, Noah
name: Huang, He
name: Hu, Xiaogang
name: Zheng, Yang
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2022

description: BACKGROUND: Myoelectric- based decoding has gained popularity in upper- limb neural-machine interfaces. Motor unit (MU) firings decomposed from surface electromyographic (EMG) signals can represent motor intent, but EMG properties at different arm configurations can change due to electrode shift and differing neuromuscular states. This study investigated whether isometric fingertip force estimation using MU firings is robust to forearm rotations from a neutral to either a fully pronated or supinated posture. METHODS: We extracted MU information from high- density EMG of the extensor digitorum communis in two ways: (1) Decomposed EMG in all three postures (MU-AllPost); and (2) Decomposed EMG in neutral posture (MU-Neu), and extracted MUs (separation matrix) were applied to other postures. Populational MU firing frequency estimated forces scaled to subjects' maximum voluntary contraction (MVC) using a regression analysis. The results were compared with the conventional EMG-amplitude method. RESULTS: We found largely similar root-mean-square errors (RMSE) for the two MU-methods, indicating that MU decomposition was robust to postural differences. MU-methods demonstrated lower RMSE in the ring (EMG = 6.23, MU-AllPost = 5.72, MU-Neu = 5.64% MVC) and pinky (EMG = 6.12, MU-AllPost = 4.95, MU-Neu = 5.36% MVC) fingers, with mixed results in the middle finger (EMG = 5.47, MU-AllPost = 5.52, MU-Neu = 6.19% MVC). CONCLUSION: Our results suggest that MU firings can be extracted reliably with little influence from forearm posture, highlighting its potential as an alternative decoding scheme for robust and continuous control of assistive devices.
Additional file 8: Figure S6. of Molecular phylogeny and dynamic evolution of disease resistance genes in the legume family
Creators: name: Fengya Zheng
name: Haiyang Wu
name: Rongzhi Zhang
name: Shiming Li
name: Weiming He
name: Fuk-Ling Wong
name: Genying Li
name: Shancen Zhao
name: Hon-Ming Lam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: The phylogenetic tree of all R-genes identified in legumes. Different colors represent R-genes with different typical domains. (PDF 2674 kb)
Additional file 1: of ELF5 isoform expression is tissue-specific and significantly altered in cancer
Creators: name: Piggin, Catherine
name: Roden, Daniel
name: Gallego-Ortega, David
name: Lee, Heather
name: Oakes, Samantha
name: Ormandy, Christopher
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Methods for additional figures, extended methods for qPCR experiments, Table S1 describing all clonal cell lines, additional Figures S1â  S10 including legends as described in the main text. (PDF 11918 kb)
Pyractomena dorsalis Motschulsky 1854
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena
Pyractomena dorsalis

description: Pyractomena dorsalis Motschulsky, 1854
MEXICO Endemic
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Additional file 1: of Psychosocial determinants of parental human papillomavirus (HPV) vaccine decision-making for sons: Methodological challenges and initial results of a pan-Canadian longitudinal study
Creators: name: Perez, Samara
name: Tatar, Ovidiu
name: Shapiro, Gilla
name: DubĂŠ, Eve
name: Ogilvie, Gina
name: Guichon, Juliet
name: Gilca, Vladimir
name: Rosberger, Zeev
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Questionnaire Sections with variable constructs, number of items, sample items and response choices. (DOCX 142Â kb)
Pyractomena gorhami McDermott 1964
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena
Pyractomena gorhami

description: Pyractomena gorhami McDermott, 1964
USA MEXICO: PU
= Pyractomena angulata Gorham, 1881
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
MOESM1 of Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects
Creators: name: Toro-Martín, Juan
name: Guénard, Frédéric
name: Tchernof, André
name: Deshaies, Yves
name: Pérusse, Louis
name: Frédéric-Simon Hould
name: Lebel, Stéfane
name: Picard Marceau
name: Marie-Claude Vohl
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 1: Table S1. Genotype distribution of genotyped and imputed SNPs within the TOMM20 locus. Figure S1. Sequence logos are the graphical representation of the Egr1 (a), Egr2 (b) and Egr3 (c) position-specific scoring matrix (PSSM) identified by TRAP and obtained from the Transfac database (IDs: M00243, M00245 and M00246, respectively). Sequence logo shows the base preference, sized and sorted relative to their occurrence in the PSSM.
Pyractomena striatella Gorham 1880
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena
Pyractomena striatella

description: Pyractomena striatella Gorham, 1880
MEXICO: CS, QR, TB; Guatemala
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Problem importance across time and space: updating the “Most Important Problem Dataset”
Creators: name: Yildirim, T. Murat
name: Williams, Laron K.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This article introduces the second release of the Most Important Problem Dataset (MIPD) – a publicly available dataset that codes all available responses to the most important problem question in American public opinion. In the article, we first describe a number of innovations in the new release of the dataset and then demonstrate its usefulness through illustrative cases. In the new MIPD, we switch from providing a single code for the entire response to the various quasi-responses contained in the response, added information on the state in which the interview took place, and subcategories that include – when relevant – information on the preferred levels of policy. These improvements allow for more fine-grained categories and facilitate more accurate inferences at the individual- and aggregate-level. We also extended the time frame through 2020. The new MIPD codes responses from over 850 surveys of more than a million Americans from 1939–2020 into 110 issue categories.
Additional file 2: Figure S1. of Molecular phylogeny and dynamic evolution of disease resistance genes in the legume family
Creators: name: Fengya Zheng
name: Haiyang Wu
name: Rongzhi Zhang
name: Shiming Li
name: Weiming He
name: Fuk-Ling Wong
name: Genying Li
name: Shancen Zhao
name: Hon-Ming Lam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: The orthologous gene families within the legumes with grape as the out-group. (A) Category of gene orthologs in legumes; (B) A Venn diagram showing the number of genes common among wild soybean (G. soja), cultivated soybean (G. max), barrel clover (M. truncatula) and chickpea (C. arietinum). (PDF 428 kb)
Fingerprinting the nonlinear rheology of a liquid crystalline polyelectrolyte
Creators: name: Dingemans, Theo J.
name: Forest, M. Gregory
name: Picken, Stephen J.
name: Fox, Ryan J.
name: Do, Changwoo
name: Chen, Wei-Ren
Publisher: name: Springer Nature
Year: 2020

description: We report on the rheology of isotropic and nematic aqueous solutions of a sulfonated all-aromatic polyamide, poly(2,2′-disulfonyl-4,4′-benzidine terephthalamide) (PBDT), that forms high-aspect-ratio rod-like assemblies. For quiescently isotropic solutions, the concentration dependence of the zero-shear viscosity, longest relaxation time, and terminal modulus shows deviations in comparison to the Doi-Edwards theory for hard rods. For quiescently nematic solutions, we characterize the flow behavior through steady-state and transient nonlinear rheological measurements in conjunction with small-angle neutron scattering under shear. The steady-state flow curve is characterized by two anomalous shear thickening responses, one at moderate shear rates and the other immediately prior to flow alignment at high shear rates. We assign the origin of these shear thickening response to director “kayaking” and “out-of-plane steady” states, using predictions from prior high-resolution numerical simulations of sheared nematic rods. Utilizing transient shear flow reversals and step-down experiments, we characterize the oscillatory response of the nematic director through these flow regimes. When the first normal stress difference is plotted versus the shear stress during a transient step-down, the so-called dynamic stress path, the counterclockwise versus clockwise rotation has previously been shown to reveal the relative dominance of viscous versus elastic contributions to the stress tensor, respectively. Our measurements strongly suggest that the anomalous shear thickening behavior in nematic PBDT solutions arises from viscous stresses developed as the ensemble of rods undergoes periodic
Applications of microwave technology to wastewater treatment
Creators: name: Yin, Guiqing
Publisher: name: University of British Columbia
Year: 2008

description: A microwave enhanced advanced oxidation process using hydrogen peroxide (MW/H₂O₂-AOP) was used for the release of nutrients and the destruction of solids from secondary municipal sewage sludge. The significant factors affecting the MW/H₂O₂-AOP that would yield maximum soluble substrates were studied. Using a computer statistical software package for experimental design and data analysis, four factors including microwave heating temperature, heating time, hydrogen peroxide dosage, and sludge solids content, were selected and examined. The initial sludge TS content and hydrogen peroxide dosage were the most significant factors for the solubilization of COD and nutrients release under the experimental conditions selected in this study. Overall, the maximum solubilization of nutrients was obtained at 2.5 % of total solids content, 2% of hydrogen peroxide by weight, 5 min. of microwave heating and 120 ºC. The effects of combination of microwave treatment and oxidative reagents on solids destruction and nutrients release were also investigated. Microwave enhanced advanced oxidation processes (MW-AOP), such as MW/O₃, MW/H₂O₂ and MW/H₂O₂/O₃, were conducted at 100 °C. In terms of nutrients release and solids reduction, the MW/H₂O₂/O₃-AOP yielded the best result. Subsequently, three factors including microwave heating temperature, hydrogen peroxide dosage, and ozone dosage, were investigated. The best result, in terms of the release of phosphate and ammonia, and solids reduction, was obtained with additions of 2 % hydrogen peroxide by weight and ozone dosage of 5.09 mg/ml, and operating at 120ºC. About 95%, 32% and 78% of TP, TKN and COD were released into the solution, respectively. The microwave enhanced advanced oxidation processes, with and without an addition of ferrous sulfate (MW/H₂O₂-AOP and MW/H₂O₂/Fe+²-AOP), were also studied for reducing solids, and solubilizing nutrients from the secondary sewage sludge. For the MW/H₂O₂/Fe+²-AOP, the best results of solubilization, in terms of orthophosphate, ammonia and soluble chemical oxygen demand, were obtained at treatment temperatures of 40 ºC, the yields decreased as the temperature was increased. The highest yields of solubilization were obtained at 60 ºC for orthophosphate, and at 80 ºC for both ammonia and soluble chemical oxygen demand.
Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression
Creators: name: Duronio, Robert J.
name: Geisler, Mark S.
name: Kemp, James P.
Publisher: name: Taylor & Francis
Year: 2023

description: Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and instead end in a conserved 3' stem loop critical for coordinated production of histone proteins during S phase of the cell cycle. Several evolutionarily conserved factors necessary for synthesis of RD histone mRNAs concentrate only in the HLB. Moreover, because HLBs are present throughout the cell cycle even though RD histone genes are only expressed during S phase, changes in HLB composition during cell cycle progression drive much of the cell cycle regulation of RD histone gene expression. Thus, HLBs provide a powerful opportunity to determine the cause-and-effect relationships between nuclear body formation and cell cycle regulated gene expression. In this review, we focus on progress during the last five years that has advanced our understanding of HLB biology.
Pyractomena vexillaria Gorham 1881
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Pyractomena
Pyractomena vexillaria

description: Pyractomena vexillaria Gorham, 1881
USA; MEXICO: VE, TB
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Additional file 5: Figure S2. of Triatomine bugs, their microbiota and Trypanosoma cruzi: asymmetric responses of bacteria to an infected blood meal
Creators: name: SebastiĂĄn DĂ­Az
name: Villavicencio, Bianca
name: NathĂĄlia Correia
name: Costa, Jane
name: Haag, Karen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Metabarcoding primers and their annealing sites on the 7 copies of the 16S rRNA gene of the Serratia marcescens genome (avalilable at http://www.ncbi.nlm.nih.gov/genome/1112). (PDF 929 kb)
t-channel single-top production: the contribution of non-factorisable corrections
Creators: name: Brønnum-Hansen, Christian
name: Juvin-Quarroz, Jérémie
name: Signorile-Signorile, Chiara
name: Wang, Chen-Yu
Publisher: name: Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Year: 2024

description: In this document we summarise the results obtained for the non-factorisable corrections to t-channel single-top production [6–8] and discuss their relevance for 13 TeV and 100 TeV proton-proton collisions. As illustrative outcomes of our study, we present results for the total cross section and for selected observables relevant for proton-proton collisions at the LHC and the FCC.
Additional file 3: Figure S2. of Molecular phylogeny and dynamic evolution of disease resistance genes in the legume family
Creators: name: Fengya Zheng
name: Haiyang Wu
name: Rongzhi Zhang
name: Shiming Li
name: Weiming He
name: Fuk-Ling Wong
name: Genying Li
name: Shancen Zhao
name: Hon-Ming Lam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: A schematic workflow of the pipeline for R-gene identification. (PDF 366 kb)
Tenaspis LeConte 1881
Creators: name: Pérez-Hernández, Cisteil X.
name: Zaragoza-Caballero, Santiago
name: Romo-Galicia, Alberto
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Tenaspis

description: Genus Tenaspis LeConte, 1881
NAR: SO; MTZ: CS; NTR: VE
=Hyas Laporte, 1833
description: Published as part of Pérez-Hernández, Cisteil X., Zaragoza-Caballero, Santiago & Romo-Galicia, Alberto, 2022, Updated checklist of the fireflies (Coleoptera: Lampyridae) of Mexico, pp. 291-317 in Zootaxa 5092 (3) on page 300, DOI: 10.11646/zootaxa.5092.3.3, http://zenodo.org/record/5881269
Antibody protection from SARS-CoV-2 respiratory tract exposure and infection
Creators: name: Wessler, Timothy
name: Chen, Alex
name: Forest, M. Gregory
Publisher: name: Elsevier
Year: 2022

description: The COVID-19 pandemic has underscored the need to understand the dynamics of SARS-CoV-2 respiratory infection and protection provided by the immune response. SARS-CoV-2 infections are characterized by a particularly high viral load, and further by the small number of inhaled virions sufficient to generate a high viral titer in the nasal passage a few days after exposure. SARS-CoV-2 specific antibodies (Ab), induced from vaccines, previous infection, or inhaled monoclonal Ab, have proven effective against SARS-CoV-2 infection. Our goal in this work is to model the protective mechanisms that Ab can provide and to assess the degree of protection from individual and combined mechanisms at different locations in the respiratory tract. Neutralization, in which Ab bind to virion spikes and inhibit them from binding to and infecting target cells, is one widely reported protective mechanism. A second mechanism of Ab protection is muco-trapping, in which Ab crosslink virions to domains on mucin polymers, effectively immobilizing them in the mucus layer. When muco-trapped, the continuous clearance of the mucus barrier by coordinated ciliary propulsion entrains the trapped viral load toward the esophagus to be swallowed. We model and simulate the protection provided by either and both mechanisms at different locations in the respiratory tract, parametrized by the Ab titer and binding-unbinding rates of Ab to viral spikes and mucin domains. Our results illustrate limits in the degree of protection by neutralizing Ab alone, the powerful protection afforded by muco-trapping Ab, and the potential for dual protection by muco-trapping and neutralizing Ab to arrest a SARS-CoV-2 infection. This manuscript was submitted as part of a theme issue on "Modelling COVID-19 and Preparedness for Future Pandemics".