cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adaptation of MelanomaMine and LiMTox to the analysis of paediatric cancers and application to biomedical publications on paediatric cancers
Creators: name: Cirillo, Davide
name: Manica, Matteo
name: Capella-Gutierrez, Salvador
name: Valencia, Alfonso
name: Krallinger, Martin
name: Corvi, Javier Omar
name: Fernández, José María
name: Canosa, Alejandro
name: De La Calle, Elena
name: Costa, Joao Pita
name: Modic, Jolanda
Publisher: name: Zenodo
Year: 2021
Subjects: Text mining
Named entity recognition
Word embeddings
Network biology

description: This is the accepted iPC deliverable D3.2 „Adaptation of MelanomaMine and LiMTox to the analysis of paediatric cancers and application to biomedical publications on paediatric cancers“. The deliverable reports on the implementation of the iPC text mining workflow and three use cases for extracting biomedical information from large volumes. The workflow builds on the general framework of two text mining tools, LimTox and MelanomaMine. These tools will be used in the framework of the iPC project but also beyond, having a clear impact in the research community.
Glutaminase regulates extracellular vesicles release through key metabolic intermediate α-ketoglutarate in HIV-1-infected macrophages
Creators: name: Wu, Beiqing
name: Huang, Yunlong
name: Zhao, Runze
name: Li, Yuju
name: Wang, Yi
name: Zheng, Jialin Charles
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Extracellular vesicles (EVs) are important in the intercellular communication in the CNS and their release is increased upon neuroinflammation. Our previous data demonstrated the increased release of EVs induces neurotoxicity during HIV-1 infection. However, the molecular mechanism by which HIV-1 increases EV release remains unknown. In current study, we investigated glutaminase (GLS), a mitochondria enzyme critical for glutamine metabolism, in EV release. We used transmission electron microscopy, NanoSight and Western blot to quantify and confirm the elevation of EV release in HIV-1-infected macrophages. Interestingly, overexpression of GLS led to increased release of EVs. Blocking the GLS activity by GLS inhibitors significantly reduced EV release, suggesting a critical role of GLS in EV release. Furthermore, the inhibited EV release was reversed by the addition of α-ketoglutarate, identifying it as a critical downstream effector for GLS inhibitors. Consistently, the EV levels were significantly higher in GLS-transgenic mice than control mice, suggesting that GLS increases EV release in vivo. In conclusion, these findings support GLS as an essential enzyme that regulates EV release through key metabolic intermediate α-ketoglutarate during HIV-1 infection. Therefore, GLS inhibitors may serve as novel therapeutic agents to block the adverse effect of EVs during HIV-1 neurological complications.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Ochterus perbosci
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Ochteridae
Ochterus
Ochterus perbosci

description: Ochterus perbosci (Guérin-Méneville, 1843)
 Geographic distribution. United States (Schell 1943), Mexico (Guérin-Méneville 1843), Guatemala (Osborn & Drake 1915), Belize (D. Polhemus & J. Polhemus 2016), Honduras (Passoa 1983), Nicaragua (Nieser 1975), Costa Rica (Schell 1943), Panama (Drake 1952c), Aruba, Curaçao (Cobben 1960b), St. Vincent & the Grenadines (Uhler 1893), Grenada (Uhler 1894a), Trinidad & Tobago (Nieser & Alkins-Koo 1991), Colombia (Drake 1952c), Venezuela (D. Polhemus & J. Polhemus 2016), Suriname (Nieser 1975), Brazil (Nieser & Melo 1997), Ecuador, Peru, Paraguay (Schell 1943).
 Distribution in Peru. Madre de Dios (Peralta-Argomeda 2011), unknown department (Schell 1943; Drake 1952c).
 Notes. Some of the specimens recorded from St. Vincent & the Grenadines and Grenada as Pelogonus marginatus Latreille, 1804 (= O. marginatus (Latreille, 1804)) (Uhler 1893, 1894a) actually belong to this species (Kment et al. 2020). Records from Cuba are erroneous (Muñoz et al. 2010; D. Polhemus & J. Polhemus 2016). The incorrect subsequent spelling in prevailing usage “ perbosci ” (instead of the original spelling “ perboscii ”) was fixed by Kment et al. (2020).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 42, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
University of Limerick’s MA in technical communication and e-learning
Creators: name: Slattery, Darina M.
name: Cleary, Yvonne
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 47
subject: Language, communication and culture

description: This article describes the mission, history, development, structure, and curriculum of the MA in Technical Communication and E-Learning, which is offered by the University of Limerick. The program started as a Graduate Diploma/ MA in Technical Communication but merged with the MA in E-Learning Design and Development in 2010. While the curriculum has evolved over the years, the overriding skill set of graduates remains constant; graduates are able to write clear, concise content for a range of media. In addition to discussing the curricular changes and structure, this article describes the typical roles filled by graduates, the faculty involved in the program, and the challenges they face administering the program.
Integration of INtERAcT, MelanomaMine and LimTox and application to biomedical publications on paediatric cancers
Creators: name: Manica, Matteo
name: Cirillo, Davide
Publisher: name: Zenodo
Year: 2021
Subjects: Natural Language Processing
Word embeddings
Text mining
Network medicine

description: This is the accepted iPC deliverable D3.3 „Integration of INtERAcT, MelanomaMine and LimTox and application to biomedical publications on paediatric cancers“. This deliverable reports on the integration of INtERAcT and the implemented text mining workflow. The workflow was developed to adapt LimTox and MelanomaMine to pediatric tumor abstracts from PubMed and relies on INtERAcT in its downstream component of inferring molecular associations between entities extracted from unstructured text.
TNF-α promotes mouse astrocytes microvesicles release through raised glutaminase
Creators: name: Wang, Kaizhe
name: Ye, Ling
name: Wu, Beiqing
name: Huang, Yunlong
name: Zheng, Jialin
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Microvesicles (MVs) containing proteins, lipids, and nucleotides that are shed from the surfaces of cells play an important novel vector in cell communication. Previous studies have demonstrated that inhibiting glutamine metabolism significantly impairs MVs production in cancer cells. However, little is known about glutaminase (GLS) for MVs release in normal cells. Our previous studies showed that tumor necrosis factor-α (TNF-α) can promote the expression of GLS in neurons and microglial. We posit that TNF-α can promote the release of MVs in astrocytes by promoting GLS expression. We found that treatment with TNF-α (50 ng/ml) significantly up-regulated GLS protein expression, a glutaminase isozyme, in primary mouse astrocytes. Furthermore, TNF-α can increase the reactive oxygen species (ROS) levels in the astrocytes, which can be blocked by pretreatment of glutaminase inhibitor BPTES. More importantly, astrocytes’ MVs release increased when treated with TNF-α, which can be blocked by BPTES and antioxidant N-acetylcysteine amide (NAC), suggesting that the glutaminase plays an important role in mouse astrocytes’ MVs release. These findings support glutaminase as a potential pathway/mechanism of Mvs release in neuroinflammation and therefore glutaminase may play an important role in cell communication.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Use of MALDI-TOF mass spectrometry to reveal oxidized cardiolipin species
Creators: name: Lobasso, Simona
name: Angelini, Roberto
name: Gorgoglione, Ruggiero
name: Lopalco, Patrizia
name: Belfiore, Anna
name: Corcelli, Angela
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Detection, identification, characterization and quantitation of oxidized cardiolipin forms in vivo is considered a challenging task, because these lipid species exist in low abundance in the biological systems.
 Recently it has been shown that chain-shortened products of oxidized standard phosphatidylcholines could be successfully identified by matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) (1).
 Here we have characterized oxidation products of standard tetra-linoleoyl cardiolipin, such as hydroxide- and hydroperoxide-derivatives and truncated forms, by MALDI-TOF/MS analysis. In addition, by following a recently developed protocol (2), we have analysed MALDI/TOF cardiolipin fingerprints of intact leukocytes isolated from controls and aged chronic heart failure patients, in order to check for the presence of oxidized cardiolipin species.
 The comparison of the two sets of analyses has showed MALDI signals potentially attributable to oxidized cardiolipin species in the mass spectra of patients.
 In conclusion, the use of MALDI-TOF/MS analyses on intact cells or organelles might offer novel opportunities to detect oxidized lipid species in native biomembranes.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Pyruvate Preserves Cerebroprotective Anti-Glycation Machinery after Cardiac Arrest
Creators: name: Scott, Gary
name: Mallet, Robert
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Background: Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)–induced cerebral oxidative, nitrosative and carbonyl stress injures the brain. The ischemic shift to anaerobic glycolysis, provokes excessive formation of the cytotoxic carbonyl, methyglyoxal (MG), the major glycation precursor detoxified by the glyoxalase system.  Purpose: To define the impact of CA/CCR on the MG-detoxifying cerebrocortical glyoxalase/GR system, and to test pyruvate as a therapeutic intervention. Methods: Swine underwent 10 min CA, 4 min CCR, defibrillation and 4 hr recovery, or non-arrest sham protocol. Sodium pyruvate or NaCl control was infused throughout CCR and the first 60 min recovery. Protein glycation and activities of glyoxalase-1, GR and GAPDH were measured in frontal cortex biopsied at 4 h recovery. Results: CA/CCR produced marked protein glycation which was attenuated by pyruvate treatment. Glyoxalase-1 and GR activities dropped 86 and 55%, respectively, after CA/CCR with NaCl infusion, paralleling an 80% inactivation of GAPDH. Pyruvate prevented inactivation of all 3 enzymes. Conclusions: Ischemia-reperfusion during CA/CCR disabled the brain’s anti-glycation defenses. Pyruvate restored these MG detoxification enzymes and energy production, for neurocognitive recovery.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Paraplea puella
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pleidae
Paraplea
Paraplea puella

description: Paraplea puella (Barber, 1923)
 Geographic distribution. Guam (Zack et al. 2007), United States, Mexico (Drake & Chapman 1953b), Belize (Rejmánková et al. 2006), Cuba (Barber 1939), Jamaica (Nieser 1969b), Dominican Republic (Drake & Maldonado-Capriles 1956), Puerto Rico (Barber 1923), U.S. Virgin Islands, St. Martin (Nieser 1969b), Guadeloupe (Barber 1923), Martinique (Nieser 1969b), Nicaragua (Bachmann 1997), Panama (Barber 1939), Aruba, Curaçao, Bonaire, Barbados (Nieser 1969b), St. Vincent & the Grenadines, Grenada (Barber 1939), Trinidad & Tobago (Drake & Chapman 1953b), Colombia (Alvarez & Roldán-Pérez 1983), Venezuela, Suriname (Nieser 1969b), Galápagos Islands, Ecuador (Bachmann 1979b), Peru (Peralta-Argomeda & Huamantinco-Araujo 2014).
 Distribution in Peru. Lima (Peralta-Argomeda & Huamantinco-Araujo 2014).
 Note. Specimens originally identified as Paraplea sp. by Bachmann (1979) were later attributed to P. puella by Bachmann (1997).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 42, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Curcumin and clovamide protect mesenchymal stem cells from oxidative stress
Creators: name: Antonini, Silvia
name: Oltolina, Francesca
name: Colangelo, Donato
name: Prat, Maria
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Mesenchymal stem cells (MSCs) transplantation can improve tissue repair but they have low survival, partial engraftment and migration. Herein we studied if it was possible to increase the grafting potential of MSC line m17.ASC (1) derived from mouse adipose tissue, grown both in monolayers and 3D spheroids (2). We induced peroxide oxidative stress and studied the molecular events modulated by two known protective molecules, curcumin and clovamide. Pretreatments had no effects on proliferative potential (MTT assay, trypan blue count), but counteracted apoptosis (Annexin V/Propidium iodide assay), as well as Caspase-3 and Caspase-9 activation and P53 phosphorylation (Western-Blot analyses) induced by H2O2 treatment. We  evaluated the modification in the expression of some key genes involved in oxidative stress and apoptosis (QPCR). Curcumin and clovamide pre-conditioned cells showed a gene expression profile similar to the untreated controls and prevented H2O2 gene expression modifications. Dose ranges and duration of the treatments were crucial in the determination of the protective effects. These results indicate a possible role of these molecules in protecting MSC in an oxidative tissue microenvironment, and in preserving cell graft potential.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Oxidative stress-mediated intramitochondrial translocation of Nuc1.
Creators: name: Kuberska, Renata
name: Kaniak-Golik, Aneta
name: Dzierzbicki, Piotr
name: Cieśla, Zygmunt
name: Śledziewska-Gójska, Ewa
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The yeast endo- and exonuclease Nuc1 is predominantly located in mitochondria. The major role of Nuc1 is its participation in yeast apoptosis. Büttner et al. showed that Nuc1 was translocated into the nuclei of apoptotic cells. However, the role of Nuc1 in mitochondria is not understood. It was previously reported by us and others that Nuc1 took part in the selective degradation of damaged copies of mtDNA under conditions of oxidative stress and that it was involved in mitochondrial recombination, respectively. In this study we show by subcellular fractionation that Nuc1 in standard conditions accumulates in the inner-membrane space (IMS). Interestingly, upon treatment with H2O2 Nuc1 translocates from IMS into the mitochondrial matrix. This result indicates that the presence of Nuc1 in the matrix is controlled by a mechanism that responds to the increase in the level of cellular H2O2. Using a dichlorofluorescin-based assay, we have also measured ROS levels in a nuc1∆ mutant exposed to exogenous H2O2. In these conditions, cellular ROS accumulate in the nuc1∆ strain with a different kinetic than in the reference strain. Thus, Nuc1 seems to be one of the elements of cellular response to oxidative stress.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
КОНКУРЕНТНІ СТРАТЕГІЇ В УМОВАХ СТАНОВЛЕННЯ ШТУЧНОГО ІНТЕЛЕКТУ: АДАПТАЦІЯ ТА ТРАНСФОРМАЦІЯ
Creators: name: Титаренко, В. Є.
Publisher: name: Zenodo
Year: 2025
Subjects: штучний інтелект, конкурентні стратегії, цифрова трансформація, конкурентоспроможність, конкурентні переваги.

description: У статті розглядається вплив штучного інтелекту (ШІ) на конкурентні стратегії підприємств в умовах цифрової трансформації. Аналізуються ключові зміни у традиційних підходах до конкуренції, зокрема адаптація стратегій лідерства за витратами, диференціації та фокусування. Особлива увага приділяється підвищенню гнучкості, персоналізації продуктів і послуг, а також обробці великих даних для швидкого ухвалення рішень. Досліджуються нові форми конкурентної боротьби, такі як створення екосистем і конкуренція за доступ до даних. Висновки статті підкреслюють необхідність динамічної адаптації стратегій для збереження конкурентних переваг у середовищі, що змінюється під впливом ШІ.
Impact of Yoga and Meditation on oxidative stress biomarkers and Transcriptome in Major depressive disorder (MDD).
Creators: name: Tolahunase, Madhuri
name: Sagar, Rajesh
name: Dada, Rima
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Background
 The data obtained from transcriptome analysis, a novel molecular technology, has enormous potential to develop personalized intervention strategies for Major depressive disorder (MDD). This can be integrated with conventional markers of cellular aging to identify possible responders so as to prognosticate capacity to respond to Yoga and Meditation based lifestyle intervention (YMLI).
 Methods
 To study the impact of YMLI on markers of oxidative stress and cellular aging ROS, TAC, cytochrome oxidase activity (COX) and transcriptome were analyzed. In a twelve-week, randomized, single-blind, controlled, parallel-design study, forty-two MDD patients were recruited and randomly allocated to YLI or routine medical treatment (RMT). Transcriptome profiling and oxidative stress markers assessment in blood and clinical improvement assessment (using HAM-D scale) was done pre and post intervention.
 Results
 YMLI significantly improved oxidative stress status than RMT in positive correlation with decline in MDD severity. Two transcripts (CX3CL1 and GPR50) had the strongest prognostic power to screen possible responders against oxidative stress and clinical severity (the area under the ROC curve=0.778).
 Conclusion
 YMLI may be adapted as an adjuvant to RMT in management of MDD as cause decreased expression of inflammatory pathways and up regulation of COX1 activity.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Amphiphilic Lignin Nanoparticles Made from Lignin-Acrylic Acid-Methyl Methacrylate Copolymers
Creators: name: Wang, Yingchao
name: Alipoormazandarani, Niloofar
name: Puumala, Lauren Skye
name: Gao, Weijue
name: Liu, Shanshan
name: Kong, Fangong
name: Wang, Qiang
name: Fatehi, Pedram
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2023

description: In this study, a novel amphiphilic KL-AA-MMA nanoparticle was prepared through the graft copolymerization of kraft lignin (KL) with acrylic acid (AA) and methyl methacrylate (MMA), using potassium persulfate as an initiator in a water/dimethyl sulfoxide solvent medium, which was followed by the nanoprecipitation technique using dimethylformamide as a solvent and deionized water as an antisolvent. The successful graft polymerization was verified by 1H-nuclear magnetic resonance (NMR), 31P-NMR, and Fourier transform infrared (FTIR) analyses; and the grafting yield of the generated KL-AA-MMA copolymer ranged from 68.2% to 96.5%. Transmission electron microscopy (TEM) observation revealed the formation of amorphous KL-AA-MMA nanoparticles. Additionally, KL-AA-MMA9 nanoparticles with the highest yield exhibited the minimum hydrodynamic diameter and polydispersity of 261 nm and 0.153, respectively. Moreover, the amphiphilicity of KL-AA-MMA nanoparticles was significantly improved by the grafting of MMA monomers. Finally, the adsorption performance of KL-AA-MMA nanoparticles at the xylene interface was evaluated by a quartz crystal microbalance with dissipation (QCM-D). The results demonstrated that the most amphiphilic sample, KL-AA-MMA9 nanoparticles, with the smallest hydrodynamic size displayed the highest adsorption on the oil/water interface. This product provides a wide range of applications in oil/water emulsions.
Autophagy, oxidative stress and endoplasmic reticulum stress are upregulated in the leukocytes of type 2 diabetic patients and are related to enhanced leukocyte-endothelial interactions
Creators: name: VICTOR, VICTOR
name: VICTOR, VICTOR
name: ROVIRA-LLOPIS, SUSANA
name: DIAZ-MORALES, NOELIA
name: ESCRIBANO-LOPEZ, IRENE
name: LOPEZ-DOMENECH, SANDRA
name: MARTINEZ DE MARAÑON, ARANTXA
name: FALCON, ROSA
name: RAMIREZ, CARMEN
name: HERNANDEZ-MIJARES, ANTONIO
name: ROCHA, MILAGROS
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: We aimed to assess oxidative stress, ER stress and autophagy in the leukocytes of T2D patients and to establish potential correlations among these mechanisms and leukocyte-endothelial interactions.
267 T2D patients and 193 healthy controls were enrolled in the study. Anthropometric and metabolic determinations were studied and peripheral blood leukocytes were isolated. Reactive oxygen species (ROS) production, both total and mitochondrial, was enhanced in the leukocytes of T2D patients. Furthermore, we observed higher levels of the ER stress markers GRP78, sXBP1, ATF6, P-eIF2α and CHOP in T2D vs. control subjects. Autophagy was also increased in T2D subjects, as LC3-II and Beclin1 protein levels were upregulated with respect to the control group. Leukocyte rolling velocity over the endothelium was decreased in T2D patients, and rolling flux and adhesion were increased. Interestingly, we observed correlations among oxidative/ER stress markers and autophagy, with these processes increasing in parallel. Leukocyte endothelial interactions correlated with increased ER stress.

Therefore, autophagy is activated in the leukocytes of T2D patients and oxidative and ER stress signalling pathways are implicated in the induction of autophagy. Moreover, increased ER stress correlates with exacerbated leukocyte-endothelial interactions in T2D patients, which could contribute to the development of diabetic vascular complications.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Unified field theory complete resonant Field Theory 98% probability of success ran through simulations
Creators: name: Dos Santos, Daniel
Publisher: name: Zenodo
Year: 2025

description: submitting a proposal for funding support and research collaboration on a revolutionary new scientific theory—Resonant Field Theory (RFT)—which offers a plausible path to unifying gravity with the other fundamental forces Unlocking Gravity: The Resonant Field Theory Proposal

By Daniel Dos Santos Henriques Machado

 

 

---

 

The Big Question:

What if gravity, mass, inertia — even dark matter — aren’t constants… but frequencies? What if the missing piece in physics isn't a new particle, but a vibration we haven't tuned into yet?

 

 

---

 

The Proposal:

Resonant Field Theory (RFT) is a new framework proposing that gravitational interaction can be modulated, neutralized, or redirected using precise frequencies, geometric field shaping, and piezoelectric materials like quartz.

 

The theory unifies classical mechanics, electromagnetism, and field resonance into one model — and it offers a testable pathway to what physics has been chasing for over a century: the unification of the four fundamental forces.

 

By aligning vibrational fields at resonance with the frequency of mass, RFT could explain:

 

Gravity as a tunable force

 

Dark matter as undetectable vibrational matter — out of our range, not invisible

 

Dark energy as a background oscillation we haven’t harmonized with

 

The bridge between quantum fields and spacetime curvature

 

 

 

---

 

Why This Matters:

This theory doesn’t just predict. It proposes a real experiment, a measurable outcome, and a repeatable process using known materials — quartz, vibration, geometry — in a closed-field setup.

 

It suggests that with the right resonance:

 

Mass could lift.

 

Gravity could falter.

 

Propulsion could emerge from silence, not fire.

 

 

 

---

 

Why Me?

I am an independent researcher with no formal ties — only an obsession with the truth and a vision built from logic, geometry, and deep intuition. I've written and published the full theory here and designed an experimental prototype that can be built on a small budget.

 

You don’t need to believe the theory is finished.

You just have to believe it’s worth testing.

 

 

---

 

What I’m Seeking:

 

Seed funding or microgrant to build and test the first resonant field chamber

 

Experimental collaboration or lab access

 

A serious conversation with a visionary or physicist who sees the pattern

 

 

 

---

 

If It’s Right:

 

We unify the forces.

 

We detect and understand dark matter and dark energy.

 

We take gravity off the pedestal and place it on the workbench.

 

We unlock the technology for clean lift, clean energy, and interstellar resonance-based travel.

 

 

 

---

 

Contact:

Daniel Dos Santos Henriques Machado

[Your Email Here]

[Optional: Link to short video or PDF one-pager]
title: The Levelled Geochemical Baseline of Australia - Update 2024
Creators: name: P., Main
name: P., Main
name: D. C., Champion
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2024
Subjects: subject: Australia’s Resources Framework
subject: EFTF – Exploring For The Future
subject: Inorganic geochemistry
subject: Levelling
subject: Surface Geochemistry
subject: Regolith
subject: baseline information
subject: Inorganic Geochemistry
subject: Published_External

description: Geochemistry of soils, stream sediments, and overbank sediments, plays an important part in informing geochemical environmental baselines, mineral prospectivity, and environmental management practices. Australia has a large number of such surveys, but they are spatially isolated and often used in isolation. First released in 2020, the Levelled Geochemical Baseline of Australia focused on levelling such surveys across the North Australian Craton, so that they could be used as a seamless dataset. This data release acts as an update to the Levelled Geochemical Baseline of Australia by changing the focus to national scale and incorporating recently reanalysed legacy samples.
This work was undertaken as part of the Exploring for the Future program, an eight-year program by the Australian government. The Exploring for the Future program provides precompetitive information to inform decision-making by government, community and industry on the sustainable development of Australia's mineral, energy and groundwater resources. By gathering, analysing and interpreting new and existing precompetitive geoscience data and knowledge, we are building a national picture of Australia’s geology and resource potential. This leads to a strong economy, resilient society and sustainable environment for the benefit of all Australians. This includes supporting Australia’s transition to net zero emissions, strong, sustainable resources and agriculture sectors, and economic opportunities and social benefits for Australia’s regional and remote communities. The Exploring for the Future program, which commenced in 2016, was an eight year, $225m investment by the Australian Government.
Supplementary information
Creators: name: Taku, Ongeziwe
name: Onywera, Harris
name: Mbulawa, zizipho
name: Businge, Charles
name: Meiring, Tracy L.
name: Williamson, Anna-Lise
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 60501 Bacteriology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This is the supplementary information of the manuscript entitled, "Molecular identification of cervical microbes in HIV-negative and HIV-positive women in an African setting using a customized Bacterial Vaginosis Microbial DNA qPCR Array". The supplementary information contains the following two files: TABLE S1 Distribution of the baseline characteristics of the women according to their age group. FIG S1 Cumulative prevalence of STI/pathobiont, individual STIs, and individual pathobionts according to age category of women with normal cervical cytology.
Application of software enabling computational deconvolution of bulk RNA-sequencing data to immune cell profiles of patient samples
Creators: name: Mestdagh, Pieter
name: Cobos, Francisco Avila
Publisher: name: Zenodo
Year: 2021
Subjects: Deconvolution
Transcriptomics
Immune cell

description: This is the accepted iPC deliverable D7.1 „Application of software enabling computational deconvolution of bulk RNA-sequencing data to immune cell profiles of patient samples“. Computational deconvolution of bulk RNA-sequencing data to infer cell type composition of a sample is challenging. Benchmarking of various computational deconvolution tools revealed various data processing parameters that impact deconvolution accuracy and revealed the importance of a complete reference matrix. As a complete reference matrix is often not available, an algorithm was designed that can handle missing cell types. This algorithm can be applied to establish the immune cell repertoire of primary tumor biopsies without prior knowledge of the full spectrum of cell types in the biopsy.
title: Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction
Creators: name: Tebbens, Erik Jurjen Duintjer
name: Azar, Malek
name: Friedmann, Elfriede
name: Lanzendörfer, Martin
name: Pávek, Petr
Publisher: name: Universität Kassel
Year: 2018
Subjects: subject: pregnane X receptor
subject: gene regulation
subject: mathematical models
subject: simulation
subject: 510
subject: 600
subject: Genregulation
subject: Mathematisches Modell
subject: Simulation

description: This work was supported by SVV 260 414, GAUK 110/50/75006, Czech Scientific agency (GACR 17-06841S), and EFSA-CDN (No. CZ.02.1.01/0.0/0.0/16_019/0000841) co-funded by ERDF and project No. 00.265.2015 of the Klaus Tschira Stiftung GmbH.
D8.4 – Highligts of the demodays
Creators: name: Alexopoulou
name: , Pari
name: , Martin
Publisher: name: Zenodo
Year: 2021
Subjects: Biobased
biomass
bio fuels
crops
industrial crops
marginal lands

description: Demo days
 In MAGIC a number of demo days had been organised for selected industrial crops growing on marginal lands in order to: a) to improve the harvesting for some industrial crops by proposing and applying innovative solutions and b) to show the relevant stakeholders the innovative harvesting approaches.
 The demo days had been initially scheduled to involve as many as many stakeholders as possible by including including farmers, technicians, and academics. Due to the Covid-19 pandemic situations, the involvement of people has been subjected to the local and international regulations that prevented crowded events. Below listed the organised demo days: October 2019, Romania, organished by CREA in collaboration with ECORICINUS and the targeted crop was castor bean June 2020, Spain, organished by CREA in collaboration with CCE and the targeted crop was camelina June 2021, Italy, organished by CREA in collaboration with UNIBO and the targeted crop was camelina September 2021, Greece, two demo days organished by CREA in collaboration with UTH, BIOS and CRES and the targeted crop was castor bean October 2021, Spain, organished by CIEMAT as joined event of two EU projects (MAGIC & BECOOL) and the targeted crops were perennial crops (grasses and woody species).
The Promising antioxidant future of natural tocopherol isomers from chia seeds
Creators: name: Castro-Vazquez, Lucia
name: Marset, Maria
name: Rodriguez-Robledo, Virginia
name: Lozano, Maria Victoria
name: Santander-Ortega, Manuel Jesus
name: Gonzalez-Fuentes, Joaquin
name: Marcos, Pilar
name: Villaseca, Noemi
name: Arroyo-Jimenez, María Del Mar
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Vitamin E is a generic descriptor for all a-, b-, g-, d-tocopherols and tocotrienols. Natural vitamin E, obtained from vegetable oils, seeds, cereals and nuts, mainly contain RRR-alpha-tocopherol isoforms; whereas commercial vitamin E commonly contain single (all rac) a-tocopherol. Several studies have reported higher absorption and bioavailability of food-matrix RRR-tocopherol isomers (1). Nowadays Chia seed (Salvia-hispanica-L.) have raised a great interest due to its content of essential nutrients like a-linoleic acid and antioxidants such vitamin E (2).

The aim of the present work is to obtain chia seed extracts, rich in tocopherols isomers, to be added to serum samples and compare the antioxidant power versus serum samples spiked with commercial vitamin-E isomers.

Chia seeds were processed by means of an accelerated solvent extractor ASE. Calibration curves of tocopherols were prepared in ethanol. Tocopherol isomers were quantified using HPLC, column C18 and mobile phase acetonitrile/methanol/i-propanol (40:55:5 v/v/v).  FRAP assay method, to measure the serum antioxidant activity, was performed by spectrophotometric assay as previously described (3).

Findings would indicate that natural RRR-isomers of Vitamin E from chia seeds could be successfully used to enhance FRAP-antioxidant activity in serum samples. Therefore, natural Vitamin-E is proposed as a promising strategy to be used for therapeutic purposes.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
NITRIC OXIDE AS A PROGNOSTIC FACTOR OF BONE TURNOVER: COMPARISON BETWEEN MEYLOMA BONE DISEASE PATIENTS AND PATIENTS SUFRING OF OSTEOPOROSIS FROM  EST OF ALGERIA
Creators: name: Khawla, Otmani
name: ROMUALD, MENTAVERRI
name: DALILA, NAIMI
name: NADIA, BOUDERSSA
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Nitric oxide (No) is formed by a variety of oxidative mechanisms.Myeloma bone disease (MBD) are one of the most visible aspects in Myeloma cancer.Osteoporosis is a disease characterized by low bone mass .
Our aim is to assess whether the level of serum (NO) associated with Biochemical markers of bone turnover (BMBT) in patients with  myeloma bone disease and osteoporosis (OP) patients
the serum of 40 MM patients and 27 osteoporosis patients aged between 35 and 60 has been taken  from the East of Algeria, and analysed with colometric griess assay to evaluate (No) concentration; some(B M BT) were measured by automated colometric assay. The results show that NO production was higher in the two populations (9 microM / l-12 microM / l) where high levels of (NO) correlated significantly with  some ( BMBT)  of OP patients: PAL ( p = 0.0131),  phos( p = 0.0186)  Moreover no correlation was observed in patients with (MBD)
Our results suggest that NO might be a prognostic marker of bone complications in patients with osteoporosis from east of Algeria however NO is not considered us prognostic factor of bone problem in patients with  (MBD).
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Our Practice Newsletter : By Pharmacists For Pharmacists. Issue 28
Creators: name: Gobis, Barbara
name: Nourse, Allison
name: Lim, Timothy
Publisher: name: The University of British Columbia
Year: 2023

description: Feature article: Service Design in Healthcare. Service design is the study and shaping of service experiences so that they work well for people. When the pandemic hit, the Clinic pivoted to a fully virtual service, which unveiled both the strengths and shortfalls of our workflows and operational systems, and led us to adopt new service design approaches for our staff and patients. Case: Much needed rest – investigating the use of psilocybin and prazosin for PTSD-associated insomnia. This issue’s case demonstrates how pharmacists can provide education, support and evidence-based treatment alternatives for patients seeking unauthorized substances, such as psilocybin, for therapeutic use.
Induction of oxidative stress by air pollutions: role of inorganic chemistry
Creators: name: Mazuryk, Olga
name: Regiel-Futyra, Anna
name: Mikrut, Magdalena
name: Macyk, Wojciech
name: Stochel, Grażyna
name: Van Eldik, Rudi
name: Brindell, Małgorzata
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: It is widely recognized that air pollutions play a fundamental role in the pathogenesis of the majority of civilization diseases. Preliminary experimental and epidemiological studies point at the important role of transition metals – common contaminants of environmental pollution – in the initiation and progression of various autoimmune disorders.
 Our hypothesis is that the inorganic fraction of air pollutants (in particular redox-active transition metal elements) possesses a greater risk to human health due to the ability to catalyze different oxidation reactions including the production of reactive oxygen species (ROS), whereas organic pollutants can produce ROS mainly in a stoichiometric way.
 The atmospheric particulate matter reference sample SRM 1648a, collected in an urban area, was purchased from the National Institute of Standards and Technology USA. The organic components were largely removed by using a low-temperature plasma technique. Physicochemical characterization of the samples was done by using scanning electron microscopy and elemental analysis. Biological studies comprised evaluation of the cytotoxicity of unmodified and plasma-treated samples, as well as ROS production.
 Our results clearly indicate that the organic fraction of air pollutions has a negligible impact on ROS production supporting our hypothesis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Impact of Yoga/Meditation on quality of life and semen quality in fathers of children affected with Retinoblastoma
Creators: name: BISHT, SHILPA
name: KUMAR BISWAS, VIPLOV
name: CHAWLA, BHAVNA
name: DADA, RIMA
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Introduction and Objectives: Sperm DNA integrity is very essential for the birth of healthy offspring. Life style habits adopted by father adversely affect sperm DNA integrity. Yoga/meditation are being increasingly used as adjuncts to modern medicine in treatment of several clinical conditions. In the present study, we analysed the effects of yoga/meditation on seminal oxidative stress (OS) and sperm DNA integrity in fathers of children affected with Retinoblastoma (RB).Methods: A total of 70 men were recruited in this study. Semen samples were collected at base line (day 0), 3 months and after 6 months of yoga/meditation intervention. Reactive oxygen species (ROS), DNA fragmentation index (DFI) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels were estimated at day 0, 3 months and 6 months.Results: There was reduction in mean DFI levels (p=0.63) at 3 months and 6 months (p=0.004), seminal mean ROS levels (p=0.74) at 3 months and 6 months (p=0.006), 8-OHdG levels at 3 months (p=0.68) and 6 months (p=0.022) with respect to the base line levels (day 0).Conclusion: Yoga/meditation may significantly lower OS and oxidative nuclear DNA damage, and levels of the mutagenic base 8-OHdG. Thus yoga/meditation are simple life style interventions which are therapeutic for maintaining/restoring sperm DNA integrity.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
SMOKELESS TOBACCO EFFECTS ON THE ANTIOXYDANT STATUTE, BIOCHEMICAL PARAMETERS AND HISTOPATHOLOGIC CHANGES IN WISTAR RATS
Creators: name: Khaldi, Taha
name: Abdellaoui, Mohamed
name: Ailane, Leila
name: Messarah, Mahfoud
name: Boumendjel, Amel
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The present study was conceived to evaluate the effects of the short-term administration of aqueous extract of ST at a dose of 40 mg/kg of body weight during two weeks on the statute of enzymatic antioxidant defense, lipid peroxidation, biochemical parameters and histopathological changes of the liver, of the lung and of the kidneys in male Wistar rats.
 The administration of ST to the rats caused a significant increase of total proteins, transaminases; ASAT and ALAT, PAL (alkaline phosphatase), Albumin and Creatinine, while comparing them with the control group.
 Thus, we noted that ST exerts a pro-oxidant effect which is shown on the one hand, by a significant increase of the rate of MDA in the erythrocytes, the liver and the lungs. In addition, by a significant decrease of the activity of the antioxidant enzymes: GPx in the erythrocytes, the liver and the lungs; CAT in the erythrocytes, the liver and the lungs, and SOD in the erythrocytes, the liver and the lungs.
 Moreover, the harmful effects of the cytotoxicity caused by the ST on pulmonary tissue architecture, hepatic and renal, were revealed by an important cellular amendment.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Community-Led Infrastructures for Open Access Books: A Sustainable Model and Platform
Creators: name: Fathallah, Judith
name: Grady, Tom
name: Eve, Martin
Publisher: name: Zenodo
Year: 2022

description: This talk introduces the work of the COPIM project (Community-Led Infrastructures for Open Access Books), then elaborates on our project of establishing the Open Book Collective and platform. The OBC, a charitable entity, will host an infrastructure and revenue management platform for the support, access, distribution and promotion of OA Books beyond inequitable book processing models. We then discuss a revenue model for publishers who wish to flip to an OA model without charging BPCs. This ‘Opening the Future’ model has already been successfully implemented by two publishers, the CEU Press and Liverpool University Press. We submit this proposal under the theme of sustaining positive change. The international move towards OA book publishing, in alignment with principles of cOAlition S, must be approached through models that render OA books equitable and accessible to the widest variety of international readers and authors. This necessitates thinking beyond BPC and the potential monopolisation of the OA landscape by major publishers, supporting a diversity of approaches in a networked model we call ‘scaling small’.
Part I. Iodometric Determination of Copper. Section I. The Use of Thiocyanate.  Section II. The Use of Sulfate-Hydrogen Sulfate Buffers. Part II. The Use of Iodine Monochloride End-Point for the Titration of Antimony Using Ceric Sulfate, Potassium Permanganate and Potassium Iodate Solutions. Part III. The Use of Iodine Monochloride as an Indicator in the Titration of Thiocyanate with Permanganate, Iodate and Ceric Sulfate. Part IV. The Distribution of Thallium Between Isopropyl Ether and Hydrochloric Acid
Creators: name: Hammock, Edward Woodrow
Publisher: name: California Institute of Technology
Year: 1947
Subjects: (Chemistry)
Chemistry

description: I. This part of the thesis reports a study of some of the limitations
encountered in the iodometric determination of copper. The sulfate-hydrogen
sulfate buffer was introduced for this determination. The permissible pH
range for this buffer was found to be from about O.5 to 3. It was found
that the "oxygen error" was not noticeable even at the lower limits of this
range and the end-points were stable enough for a normal titration. Chlorides
and nitrates do not cause serious errors. The procedure using the sulfate
buffers and thiocyanate was tested against pure copper and copper alloys
which contain interfering constituents. The results show that the percentage
difference from the theoretical is less than one part per thousand.

The effect of adding thiocyanate at various points during the titration,
the amount required, and the necessity of using pure thiocyanate
were studied and reported. A study of the difference of the iodide and thiocyanate
end-points was made. It was observed that a small excess of thiosulfate
could be back titrated. Several wetting agents as well as shellac were
tried in an attempt to protect the cuprous iodide during this back titration.

II. A study has been made of the titration of antimony with permanganate,
eerie sulfate, and iodate solutions, using the iodine monochloride as
the indicator. The oxidizing solutions were standardized against Bureau of
Standards arsenious oxide by two methods which agreed within one part per
thousand. In the analysis of an antimony ore, the amount of antimony found
was about three parts per thousand too high of that present.

III. A study of the titration of thiocyanate has been made in which
permanganate, iodate and eerie sulfate were used as the oxidizing agents,
and iodine monochloride used as the indicator. Results show that iodate
titration gives results within one part per thousand, the permanganate
titration within three parts per thousand, and eerie sulfate titration was
not satisfactory. Potassium thiocyanate can be used as a primary standard.

IV. This report is a progress report on the study of the distribution
of thallium between isopropyl ether and hydrochloric acid solution. The
method for purifying the ether and the method of the analyzing the ether
and water layers is given. There is not sufficient data to draw any definite
conclusions as to the distribution curve nor the extracted species.
An interactive online atlas of interconnected network maps based on the NaviCell platform
Creators: name: Saez-Rodriguez, Julio
name: Hernansaiz, Rosa
name: Noël, Vincent
name: Kuperstein, Inna
name: Ravel, Jean-Marie
name: Zinovyev, Andrei
Publisher: name: Zenodo
Year: 2021
Subjects: Maps
Network
Data visualization
Web

description: This is the accepted iPC deliverable D4.2 „An interactive online atlas of interconnected network maps based on the NaviCell platform“. With the development of the NaviCell 3.0 web server, there is a complete and automated web-based infrastructure for hosting molecular maps, patient similarity network maps, and multi-omics datasets for the project. The NaviCell platform supports molecular map navigation and exploration using the Google maps™ engine. The logic of navigation is taken from Google maps. This NaviCell 3.0 web-server is freely available and several step-by-step tutorials are accessible.