cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Small molecule drug development for rare genodermatoses – evaluation of the current status in epidermolysis bullosa
Creators: name: Wally, Verena
name: Reisenberger, Manuela
name: Kitzmüller, Sophie
name: Laimer, Martin
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Clinical trials published for the treatment of EB using small molecules. This table is a summary of published small molecules in the therapy of Epidermolysis bullosa. Publications are ordered by EB subtype and type of trial (RCT, CT, case study), most recent publications on top of each section. The benefit for the patient was clustered into the groups reduction of blister numbers, itch reduction, pain reduction, improvement of wound healing, prevention and treatment of SCCs, and others. Others include QoL (n = 1), relieve anal sphincter spasm and fissuring (n = 1), lower stricture indices in esophageal stenosis (n = 1), plasma phospholipid and fatty acid profiles (n = 1), and reduction of inflammation (n = 1). na: not applicable. * Primary or clinically relevant endpoints are given for RCT trials. # Indicates drugs that are currently under clinical investigation in recruiting or running registered trials (Table S2)
THE IMPORTANCE OF TEACHING WRITING SKILLS OF SCHOOL STUDENTS (9th FORM)
Creators: name: Koshayova, Sansabila
Publisher: name: Zenodo
Year: 2023

description: This article describes the concept of disciplinary literacy and emphasizes its relevance to teaching writing in specific subject areas. This article analyzes the significance of teaching writing skills to ninth-grade students. The paper deals with the statement that effective writing is a critical skill that not only contributes to academic success but also plays a pivotal role in personal and professional development. This analysis highlights the benefits of a comprehensive writing curriculum, its impact on cognitive development, and its role in fostering critical thinking and communication abilities.
(500819) ? Green
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Flour Exchange Problem: A Potential Contradiction in Special Relativity
Creators: name: Bouzouina Zaidi, Yassin
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Special Relativity
subject: Time Dilation,
subject: Reference Frames,
subject: Physics
subject: Theoretical physics

description: In this paper, I delve into a scenario that highlights a potential contradiction in special relativity, termed the "flour exchange problem." The analysis involves two observers in separate reference frames moving at significant relative velocity, each operating a flour factory. Due to time dilation, each observer perceives the other's time as passing more slowly. When these observers exchange flour, a paradox arises: each expects to receive a different quantity of flour than what is actually produced, based on their perception of time dilation. This contradiction questions the fundamental principles of special relativity, particularly the nature of time dilation and simultaneity. The implications of this problem are profound, suggesting the need for a re-evaluation of some aspects of the theory. This paper is intended to provoke discussion and further investigation within the physics community.
(500843) Russell Pontifex
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior
Creators: name: Gilpin, Nicholas W
name: Jiang, Zhiying
name: Douglass, Eliza
name: Rajamanickam, Shivakumar
name: Herman, Melissa
name: Agoglia, Abigail E
name: Justice, Nicholas J
name: Weera, Marcus M
name: Shackett, Rosetta S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Corticotropin-releasing factor type-1 (CRF1) receptors are critical to stress responses because they allow neurons to respond to CRF released in response to stress. Our understanding of the precise role of CRF1-expressing neuronal populations in CRF-mediated behaviors has been largely limited to mouse experiments due to the lack of genetic tools available to selectively visualize and manipulate CRF1+ cells in rats. Here, we describe the generation and validation of a transgenic CRF1-Cre-tdTomato rat, which expresses a bicistronic iCre-2A-tdTomato transgene directed by 200kb of promoter and enhancer sequence surrounding the Crhr1 cDNA present within a BAC clone, that has been transgenically inserted into the rat genome. We report that Crhr1 and Cre mRNA expression are highly colocalized in CRF1-Cre-tdTomato rats within both the central amygdala (CeA), composed of mostly GABAergic neurons, and in the basolateral amygdala (BLA), composed of mostly glutamatergic neurons. In the CeA, membrane properties, inhibitory synaptic transmission, and responses to CRF bath application in tdTomato+ neurons are similar to those previously reported in GFP+ cells in CRFR1-GFP mice. We show that stimulatory DREADD receptors can be selectively targeted to CeA CRF1+ cells via virally delivered Cre-dependent transgenes, that transfected Cre/tdTomato+ cells are activated by clozapine-n-oxide in vitro and in vivo, and that activation of these cells in vivo increases anxiety-like behavior and nocifensive responses. Outside the amygdala, we show that Cre-tdTomato is expressed in several brain areas across the rostrocaudal axis of the CRF1-Cre-tdTomato rat brain, and that the expression pattern of Cre-tdTomato cells is similar to the known expression pattern of CRF1 cells. Given the accuracy of expression in the CRF1-Cre rat, modern genetic techniques used to investigate the anatomy, physiology, and behavioral function of CRF1+ neurons and circuits can now be performed in assays that require the use of rats as the model organism.
Dirac Phenomenological Analyses of Unpolarized Proton Inelastic Scattering from $^{22}$Ne
Creators: name: Kim, Moon-Won
name: Shim, Sugie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Unpolarized 800 MeV proton inelastic scatterings from an s-d shell nucleus $^{22}$Ne are analyzed using phenomenological optical potentials in the Dirac coupled channel formalism. The first-order rotational collective model is used to obtain the transition optical potentials for the low lying excited collective states that belong to the ground state rotational band of the nucleus. The optical potential parameters of Woods-Saxon shape and the deformation parameters of the excited states are varied phenomenologically using the sequential iteration method to reproduce the experimental differential cross section data. The effective central and spin-orbit optical potentials are obtained by reducing the Dirac equations to the Schrödinger-like second-order differential equations and the surface-peaked phenomena are observed at the real effective central potentials when the scattering from $^{22}$Ne is considered. The obtained deformation parameters of the excited states are compared with those of the nonrelativistic calculations and another s-d shell nucleus $^{20}$Ne. The deformation parameters for the $2^+$ and the $4^+$ states of the ground state rotational band at the nucleus $^{22}$Ne are found to be smaller than those of $^{20}$Ne, indicating that the couplings of those states to the ground state are weaker at the nucleus $^{22}$Ne compared to those at the nucleus $^{20}$Ne. The multistep channel coupling effect is confirmed to be important for the $4^+$ state excitation of the ground state rotational band at the proton inelastic scattering from the s-d shell nucleus $^{22}$Ne.
description: 10 pages, 4 figures. arXiv admin note: text overlap with arXiv:1407.5441
The linear velocity field of SDSS DR7 galaxies: constraints on flow amplitudes and the growth rate
Creators: name: Feix, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Large-scale peculiar motion modulates the observed luminosity distribution of galaxies. Using about half a million SDSS galaxies, this can be harnessed to obtain bounds on peculiar velocity moments, the amplitude of the linear matter power spectrum, $σ_{8}$, and the growth rate of density perturbations at z ~ 0.1. Results obtained from this approach agree well with the predictions of the $Λ$CDM model and are consistent with the reported ~ 1% zero-point tilt in the SDSS photometry.
description: Proceedings of "Frontiers of Fundamental Physics XIV" (FFP14), Marseille, France, 15-18 July 2014
Supplementary Material for Phenotyping metabolic status of dairy cows using clustering of time profiles of energy balance peripartum
Creators: name: Vossebeld, F.
name: Van Knegsel, A. T.M.
name: Saccenti, E.
Publisher: name: Zenodo
Year: 2022

description: Supplementary Material for the paper Phenotyping metabolic status of dairy cows using clustering of time profiles of energy balance peripartum by F. Vossebeld1,2, A. T.M. van Knegsel2, E. Saccenti1,* 1Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, the Netherlands. 2Adaptation Physiology group, Department of Animal Sciences, Wageningen University and Research, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.
Quantum Hall Effect in Black Phosphorus Two-dimensional Electron Gas
Creators: name: Li, Likai
name: Yang, Fangyuan
name: Ye, Guo Jun
name: Zhang, Zuocheng
name: Zhu, Zengwei
name: Lou, Wen-Kai
name: Li, Liang
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Chang, Kai
name: Wang, Yayu
name: Chen, Xian Hui
name: Zhang, Yuanbo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Development of new, high quality functional materials has been at the forefront of condensed matter research. The recent advent of two-dimensional black phosphorus has greatly enriched the material base of two-dimensional electron systems. Significant progress has been made to achieve high mobility black phosphorus two-dimensional electron gas (2DEG) since the development of the first black phosphorus field-effect transistors (FETs)$^{1-4}$. Here, we reach a milestone in developing high quality black phosphorus 2DEG - the observation of integer quantum Hall (QH) effect. We achieve high quality by embedding the black phosphorus 2DEG in a van der Waals heterostructure close to a graphite back gate; the graphite gate screens the impurity potential in the 2DEG, and brings the carrier Hall mobility up to 6000 $cm^{2}V^{-1}s^{-1}$. The exceptional mobility enabled us, for the first time, to observe QH effect, and to gain important information on the energetics of the spin-split Landau levels in black phosphorus. Our results set the stage for further study on quantum transport and device application in the ultrahigh mobility regime.
Additional file 3 of Small molecule drug development for rare genodermatoses – evaluation of the current status in epidermolysis bullosa
Creators: name: Wally, Verena
name: Reisenberger, Manuela
name: Kitzmüller, Sophie
name: Laimer, Martin
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Table S2. Currently registered clinical trials for EB investigation small molecule-based drugs. The table combines trials registered in the following databases: www.clinicaltrials.gov [15] and www.clinicaltrialsregister.eu [16]. Trials are ordered according to current status, subtype and clinical trial phase. Status definitions were adopted from www.clinicaltrials.gov . Recruiting: The study is currently recruiting participants. Active, not recruiting: The study is ongoing, and participants are receiving an intervention or being examined, but potential participants are not currently being recruited. Terminated: The study has stopped early and will not start again. Participants are no longer being examined or treated. Completed: The study has ended normally, and participants are no longer being examined or treated. Unknown: A study whose last known status was recruiting; not yet recruiting; or active, not recruiting but that has passed its completion date, and the status has not been last verified within the past 2 years. Completed registered trials that have subsequently been published are only listed in Table S1
Editorial: Advances of Targeted Therapy in Gynecologic Malignancies
Creators: name: Qiu, Haifeng
name: Zhou, Chunxiao
name: Wang, Lei
name: Song, Kun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Gynecologic malignancies, a heterogeneous group of female reproductive system tumors (including
ovarian, endometrial, cervical, vaginal and vulvar cancer), are the second most commonly
diagnosed female cancers worldwide (1). Among these cancers, cervical cancer is the most
common malignancy of the female genital tract, followed by endometrial cancer and ovarian
cancer. Most patients with early stage gynecological cancers are cured with surgery alone or a
combination of surgery, radiation and chemotherapy. However, patients with advanced, recurrent,
or metastatic disease lack effective therapeutic options and often have poor prognosis despite
appropriate managements. Therefore, there is an urgent need to develop new-targeted therapies
based on the molecular features of gynecological cancers and their microenvironment.
In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis
Creators: name: Argibay, Diana
name: Gaziel, Avital
name: Sokolova, Elena
name: Brown, Brian D.
name: de Pablos-Aragoneses, Ana
name: Berwick, Marianne
name: Thomas, Nancy E.
name: Kleffman, Kevin
name: Hernando, Eva
name: Moubarak, Rana S.
name: Osman, Iman
name: Mullokandov, Gavriel
name: Koetz-Ploch, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Melanoma is a highly prevalent cancer with an increasing incidence worldwide and high metastatic potential. Brain metastasis is a major complication of the disease, as more than 50% of metastatic melanoma patients eventually develop intracranial disease. MicroRNAs (miRNAs) have been found to play an important role in the tumorigenicity of different cancers and have potential as markers of disease outcome. Identification of relevant miRNAs has generally stemmed from miRNA profiling studies of cells or tissues, but these approaches may have missed miRNAs with relevant functions that are expressed in subfractions of cancer cells. We performed an unbiased in vivo screen to identify miRNAs with potential functions as metastasis suppressors using a lentiviral library of miRNA decoys. Notably, we found that a significant fraction of melanomas that metastasized to the brain carried a decoy for miR-124a, a miRNA that is highly expressed in the brain/neurons. Additional loss- and gain-of-function in vivo validation studies confirmed miR-124a as a suppressor of melanoma metastasis and particularly of brain metastasis. miR-124a overexpression did not inhibit tumor growth in vivo, underscoring that miR-124a specifically controls processes required for melanoma metastatic growth, such as seeding and growth post-extravasation. Finally, we provide proof of principle of this miRNA as a promising therapeutic agent by showing its ability to impair metastatic growth of melanoma cells seeded in distal organs. Our efforts shed light on miR-124a as an antimetastatic agent, which could be leveraged therapeutically to impair metastatic growth and improve patient survival.
Dermal Lymphatic Capillaries Do Not Obey Murray's Law
Creators: name: Miller, Laura A.
name: Goodwin, Emma R.
name: Datto, Nicholas C.
name: Talkington, Anne M.
name: Davis, Reema B.
name: Caron, Kathleen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Lymphatic vessels serve as a major conduit for the transport of interstitial fluid, immune cells, lipids and drugs. Therefore, increased knowledge about their development and function is relevant to clinical issues ranging from chronic inflammation and edema, to cancer metastasis to targeted drug delivery. Murray's Law is a widely-applied branching rule upheld in diverse circulatory systems including leaf venation, sponge canals, and various human organs for optimal fluid transport. Considering the unique and diverse functions of lymphatic fluid transport, we specifically address the branching of developing lymphatic capillaries, and the flow of lymph through these vessels. Using an empirically-generated dataset from wild type and genetic lymphatic insufficiency mouse models we confirmed that branching blood capillaries consistently follow Murray's Law. However surprisingly, we found that the optimization law for lymphatic vessels follows a different pattern, namely a Murray's Law exponent of ~1.45. In this case, the daughter vessels are smaller relative to the parent than would be predicted by the hypothesized radius-cubed law for impermeable vessels. By implementing a computational fluid dynamics model, we further examined the extent to which the assumptions of Murray's Law were violated. We found that the flow profiles were predominantly parabolic and reasonably followed the assumptions of Murray's Law. These data suggest an alternate hypothesis for optimization of the branching structure of the lymphatic system, which may have bearing on the unique physiological functions of lymphatics compared to the blood vascular system. Thus, it may be the case that the lymphatic branching structure is optimized to enhance lymph mixing, particle exchange, or immune cell transport, which are particularly germane to the use of lymphatics as drug delivery routes.
Editorial: Non-Invasive Measures of Cardiovascular Function and Health: Special Considerations for Assessing Lifestyle Behaviours
Creators: name: Credeur, Daniel
name: Fryer, Simon
name: Stone, Keeron
name: Stoner, Lee
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: In recent decades it has become clear that lifestyle behaviors such as diet (1), risky alcohol consumption (2), cigarette smoking (Wang et al.), sedentary behavior (3), and physical inactivity (4) are all factors contributing to cardiovascular disease (CVD) incidence and mortality. And, as cardiovascular diseases remain the largest cause of death in the Western world, gaining further knowledge of cardiovascular dysfunction in response to these lifestyle behaviors is of paramount
importance. This Research Topic which includes 14 research papers (Figure 1), has helped further our knowledge in three important areas of lifestyle behaviors and cardiovascular physiology: First, it has highlighted the importance several modifiable, behavioral risk factors associated with CVD (El-Battrawy et al.;Wang et al.; Zuo et al.), second, it has expanded our understanding of a number of biomarkers and risk scores which are related to CVD (Bo et al.; Cang et al.; Hsu et al.; Tsai et al.; Ying et al.), third it helped us to better understand and interpret markers of arterial stiffness (Elliot et al.; Lane-Cordova and Bouknight; Stone et al.) and lastly, it has allowed us to provide guidance on how to assess cardiovascular function in response to a common and biologically novel lifestyle behavior, prolonged sitting (Stoner et al.). Collectively this new information is an important step forwards in improving our understanding of CVD, and allows us to work toward the development of public health policy aimed at reducing the CVD burden.
(500947) Frederic George K. C. B. Kenyon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Microbial Mutualist Within Host Individuals Increases Parasite Transmission Between Host Individuals: Evidence From a Field Mesocosm Experiment
Creators: name: Mitchell, Charles E.
name: Wheeler, Brandon T.
name: O'Keeffe, Kayleigh R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The interactions among host-associated microbes and parasites can have clear consequences for disease susceptibility and progression within host individuals. Yet, empirical evidence for how these interactions impact parasite transmission between host individuals remains scarce. We address this scarcity by using a field mesocosm experiment to investigate the interaction between a systemic fungal endophyte, Epichloë coenophiala, and a fungal parasite, Rhizoctonia solani, in leaves of a grass host, tall fescue (Lolium arundinaceum). Specifically, we investigated how this interaction impacted transmission of the parasite under field conditions in replicated experimental host populations. Epichloë-inoculated populations tended to have greater disease prevalence over time, though this difference had weak statistical support. More clearly, Epichloë-inoculated populations experienced higher peak parasite prevalences than Epichloë-free populations. Epichloë conferred a benefit in growth; Epichloë-inoculated populations had greater aboveground biomass than Epichloë-free populations. Using biomass as a proxy, host density was correlated with peak parasite prevalence, but Epichloë still increased peak parasite prevalence after controlling for the effect of biomass. Together, these results suggest that within-host microbial interactions can impact disease at the population level. Further, while Epichloë is clearly a mutualist of tall fescue, it may not be a defensive mutualist in relation to Rhizoctonia solani.
Waveform Timing Performance of a 5 GS/s Fast Pulse Sampling Module with DRS4
Creators: name: Wang, Jinhong
name: Liu, Shubin
name: An, Qi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We first clarify timing issues of non-uniform sampling intervals regarding a 5 GS/s fast pulse sampling module with DRS4. Calibration strategy is proposed, and as a result, the waveform timing performance is improved to be below 10 ps RMS. We then further evaluate waveform timing performance of the module by comparing with a 10 GS/s oscilloscope in a setup with plastic scintillators and fast PMTs. Different waveform timing algorithms are employed for analysis, and the module shows comparable timing performance with that of the oscilloscope.
Additional file 1 of Small molecule drug development for rare genodermatoses – evaluation of the current status in epidermolysis bullosa
Creators: name: Wally, Verena
name: Reisenberger, Manuela
name: Kitzmüller, Sophie
name: Laimer, Martin
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. PRISMA 2009 Flow Diagram.
(500767) Walter Edgar Jacob
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
VIRTUAL REALLIK TEXNOLOGIYALARINING MATEMATIK MODELLARINI TAHLIL QILISH
Creators: name: Bahromov, A.A.
name: Jo'raboyev, F.A.
Publisher: name: Zenodo
Year: 2024

description: Virtual reallik (VR) texnologiyalari soniyalarda haqiqiy hayotni imitatsiya qilish imkonini beradi va foydalanuvchini simulyatsiyaga chuqur kirishga undaydi. VR texnologiyalarida asosiy hisoblangan matematik modellar haqiqiy ko‘rinish va foydalanuvchining interaktivligini ta’minlashga xizmat qiladi. Ushbu maqolada VR texnologiyalari uchun asosiy matematik modellar, ular bilan ishlashning matematik asoslari, va algoritmik yondashuvlar tahlil qilinadi.
Human Tumor Targeted Cytotoxic Mast Cells for Cancer Immunotherapy
Creators: name: Ahani, Elnaz
name: Fereydouni, Mohammad
name: Metcalfe, Dean D.
name: Bhatt, Aadra P.
name: Dellinger, Anthony
name: Kafri, Tal
name: Motaghed, Mona
name: Desai, Parth
name: Dellinger, Kristen
name: Yin, Yuzhi
name: Lee, Sung Hyun
name: Kepley, Christopher L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The diversity of autologous cells being used and investigated for cancer therapy continues to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer mediators and are found in and around tumors. We sought to exploit the anti-tumor mediators in MC granules to selectively target them to tumor cells using tumor specific immunoglobin E (IgE) and controllably trigger release of anti-tumor mediators upon tumor cell engagement. We used a human HER2/neu-specific IgE to arm human MCs through the high affinity IgE receptor (FcεRI). The ability of MCs to bind to and induce apoptosis of HER2/neu-positive cancer cells in vitro and in vivo was assessed. The interactions between MCs and cancer cells were investigated in real time using confocal microscopy. The mechanism of action using cytotoxic MCs was examined using gene array profiling. Genetically manipulating autologous MC to assess the effects of MC-specific mediators have on apoptosis of tumor cells was developed using siRNA. We found that HER2/neu tumor-specific IgE-sensitized MCs bound, penetrated, and killed HER2/neu-positive tumor masses in vitro. Tunneling nanotubes formed between MCs and tumor cells are described that parallel tumor cell apoptosis. In solid tumor, human breast cancer (BC) xenograft mouse models, infusion of HER2/neu IgE-sensitized human MCs co-localized to BC cells, decreased tumor burden, and prolonged overall survival without indications of toxicity. Gene microarray of tumor cells suggests a dependence on TNF and TGFβ signaling pathways leading to apoptosis. Knocking down MC-released tryptase did not affect apoptosis of cancer cells. These studies suggest MCs can be polarized from Type I hypersensitivity-mediating cells to cytotoxic cells that selectively target tumor cells and specifically triggered to release anti-tumor mediators. A strategy to investigate which MC mediators are responsible for the observed tumor killing is described so that rational decisions can be made in the future when selecting which mediators to target for deletion or those that could further polarize them to cytotoxic MC by adding other known anti-tumor agents. Using autologous human MC may provide further options for cancer therapeutics that offers a unique anti-cancer mechanism of action using tumor targeted IgE’s.
As Omicron Takes Hold and Other New Variants Arise, COVID-19 Testing Remains the Universally Agreed Tool to Effect Transition From Pandemic to Endemic State
Creators: name: Lee, Hyukmin
name: Gupta, Sunetra
name: Krajden, Mel
name: Ooi, Eng Eong
name: Kulldorff, Martin
name: Anderson, Danielle E.
name: Miller, Melissa B.
name: Rhoads, Daniel D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The COVID-19 pandemic has caused more than 448 million cases and 6 million deaths worldwide to date. Omicron is now the dominant SARS-CoV-2 variant, making up more than 90% of cases in countries reporting sequencing data. As the pandemic continues into its third year, continued testing is a strategic and necessary tool for transitioning to an endemic state of COVID-19. Here, we address three critical topics pertaining to the transition from pandemic to endemic: defining the endemic state for COVID-19, highlighting the role of SARS-CoV-2 testing as endemicity is approached, and recommending parameters for SARS-CoV-2 testing once endemicity is reached. We argue for an approach that capitalizes on the current public health momentum to increase capacity for PCR-based testing and whole genome sequencing to monitor emerging infectious diseases. Strategic development and utilization of testing, including viral panels in addition to vaccination, can keep SARS-CoV-2 in a manageable endemic state and build a framework of preparedness for the next pandemic.
Multiwavelength analysis of three SNe associated with GRBs observed by GROND
Creators: name: E., F. Olivares
name: Greiner, J.
name: Schady, P.
name: Klose, S.
name: Krühler, T.
name: Rau, A.
name: Savaglio, S.
name: Kann, D. A.
name: Pignata, G.
name: Elliott, J.
name: Rossi, A.
name: Nardini, M.
name: Afonso, P. M. J.
name: Filgas, R.
name: Guelbenzu, A. Nicuesa
name: Schmidl, S.
name: Sudilovsky, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: After the discovery of the first connection between GRBs and SNe almost two decades ago, tens of SN-like rebrightenings have been discovered and about seven solid associations have been spectroscopically confirmed to date. Using GROND optical/NIR data and Swift X-ray/UV data, we estimate the intrinsic extinction, luminosity, and evolution of three SN rebrightenings in GRB afterglow light curves at z~0.5. The SNe 2008hw, 2009nz, and 2010ma exhibit 0.80, 1.15, and 1.78 times the optical (r band) luminosity of SN 1998bw, respectively. While SN 2009nz evolves similarly to SN 1998bw, SNe 2008hw and 2010ma show earlier peak times. The quasi-bolometric light curves were corrected for the contribution of the NIR bands using data available in the literature and blackbody fits. The large luminosity of SN 2010ma (1.4x10^43 erg/s) is confirmed, while SNe 2008hw and 2009nz reached a peak luminosity closer to SN 1998bw. Physical parameters of the SN explosions, such as synthesised nickel mass, ejecta mass, and kinetic energy, are estimated using Arnett's analytic approach, which resulted in nickel masses of around 0.4-0.5 Msun. By means of the a very comprehensive data set, we found that the luminosity and the nickel mass of SNe 2008hw, 2009nz, and 2010ma resembles those of other known GRB-associated SNe. This findings strengthens previous claims of GRB-SNe being brighter than type-Ic SNe unaccompanied by GRBs.
description: 11 pages, 9 figures, accepted for publication in Astronomy & Astrophysics, abstract abridged
Hostile Intent Identification by Movement Pattern Analysis: Using Artificial Neural Networks
Creators: name: Biswas, Souham
name: Nene, Manisha J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: In the recent years, the problem of identifying suspicious behavior has gained importance and identifying this behavior using computational systems and autonomous algorithms is highly desirable in a tactical scenario. So far, the solutions have been primarily manual which elicit human observation of entities to discern the hostility of the situation. To cater to this problem statement, a number of fully automated and partially automated solutions exist. But, these solutions lack the capability of learning from experiences and work in conjunction with human supervision which is extremely prone to error. In this paper, a generalized methodology to predict the hostility of a given object based on its movement patterns is proposed which has the ability to learn and is based upon the mechanism of humans of learning from experiences. The methodology so proposed has been implemented in a computer simulation. The results show that the posited methodology has the potential to be applied in real world tactical scenarios.
description: To appear in IEEE Xplore as a part of the proceedings of the 3rd IEEE International Conference on Parallel, Distributed and Grid Computing, 2014, at Jaypee University of Information Technology, Solan
(500784) Kerenhappuck Partridge
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Computationally-efficient stochastic cluster dynamics method for modeling damage accumulation in irradiated materials
Creators: name: Hoang, Tuan L.
name: Marian, Jaime
name: Bulatov, Vasily V.
name: Hosemann, Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: An improved version of a recently developed stochastic cluster dynamics (SCD) method {[}Marian, J. and Bulatov, V. V., {\it J. Nucl. Mater.} \textbf{415} (2014) 84-95{]} is introduced as an alternative to rate theory (RT) methods for solving coupled ordinary differential equation (ODE) systems for irradiation damage simulations. SCD circumvents by design the curse of dimensionality of the variable space that renders traditional ODE-based RT approaches inefficient when handling complex defect population comprised of multiple (more than two) defect species. Several improvements introduced here enable efficient and accurate simulations of irradiated materials up to realistic (high) damage doses characteristic of next-generation nuclear systems. The first improvement is a procedure for efficiently updating the defect reaction-network and event selection in the context of a dynamically expanding reaction-network. Next is a novel implementation of the $τ$-leaping method that speeds up SCD simulations by advancing the state of the reaction network in large time increments when appropriate. Lastly, a volume rescaling procedure is introduced to control the computational complexity of the expanding reaction-network through occasional reductions of the defect population while maintaining accurate statistics. The enhanced SCD method is then applied to model defect cluster accumulation in iron thin films subjected to triple ion-beam ($\text{Fe}^{3+}$, $\text{He}^{+}$ and $ $$\text{H\ensuremath{{}^{+}}}$$ $) irradiations, for which standard RT or spatially-resolved kinetic Monte Carlo simulations are prohibitively expensive.
Treatment of PDMS surfaces using pulsed DBD plasmas: comparing the use of different gases and its influence on adhesion
Creators: name: Nascimento, Fellype do
name: Moshkalev, Stanislav
name: Machida, Munemasa
name: Parada, Sergio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: In this work we present some results of the treatment of polydimethylsiloxane (PDMS) surfaces using pulsed dielectric barrier discharge plasmas. The results of plasma treatment using different gases and mixtures, argon, argon plus water vapor, helium, helium plus water vapor, nitrogen and nitrogen plus water vapor, were compared testing the adhesion between two PDMS samples for each kind of plasma. We also studied the water contact angle in function of plasma process time of PDMS surfaces with each kind of plasma treatment. The plasma was characterized by optical emission spectroscopy (OES) to identify the emitting species and determine the plasma temperatures. The plasma temperature for each process was estimated comparing the spectrum obtained by OES with the spectrum generated by SpecAir simulation code. Measurements of power delivered to the plasmas were also performed. As the results, all the process using different gases show good adhesion efficacy between PDMS samples when long exposure time (larger than 150 seconds) is applied. However, when only a few discharges are applied to PDMS samples the helium plasma process presented best results. Atomic Force Microscopy (AFM) analysis of PDMS samples treated with helium plasma showed reduction in the surface roughness, which increase the surface contact area and improves the adhesion.
description: 14 pages, 16 figures
Additional file 8 of Transcriptome-IPMS analysis reveals a tissue-dependent miR156/SPL13 regulatory mechanism in alfalfa drought tolerance
Creators: name: Biruk A. Feyissa
name: Renaud, Justin
name: Nasrollahi, Vida
name: Kohalmi, Susanne E.
name: Hannoufa, Abdelali
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 8: Table S7.. Shell scripts of Linux and R-software scripts used to analyze and visualize data.
Hunting for Supermassive Black Holes in Nearby Galaxies with the Hobby-Eberly Telescope
Creators: name: Bosch, Remco van den
name: Gebhardt, Karl
name: Gültekin, Kayhan
name: Yıldırım, Akin
name: Walsh, Jonelle
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have conducted an optical long-slit spectroscopic survey of 1022 galaxies using the 10m Hobby-Eberly Telescope (HET) at McDonald Observatory. The main goal of the HET Massive Galaxy Survey (HETMGS) is to find nearby galaxies that are suitable for black hole mass measurements. In order to measure accurately the black hole mass, one should kinematically resolve the region where the black hole dominates the gravitational potential. For most galaxies, this region is much less than an arcsecond. Thus, black hole masses are best measured in nearby galaxies with telescopes that obtain high-spatial resolution. The HETMGS focuses on those galaxies predicted to have the largest sphere-of-influence, based on published stellar velocity dispersions or the galaxy fundamental plane. To ensure coverage over galaxy types, the survey targets those galaxies across a face-on projection of the fundamental plane. We present the sample selection and resulting data products from the long-slit observations, including central stellar kinematics and emission line ratios. The full dataset, including spectra and resolved kinematics, is available online. Additionally, we show that the current crop of black hole masses are highly biased towards dense galaxies and that especially large disks and low dispersion galaxies are under-represented. This survey provides the necessary groundwork for future systematic black hole mass measurement campaigns.
description: 12 pages, 10 figures and a 17 page data table, ApJs accepted. Survey data files at http://mpia.de/~bosch/hetmgs
(500231) Arthur Paul
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(500404) William Crowther
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Understanding physical literacy in the context of health: a rapid scoping review
Creators: name: Cornish, Katie
name: Fox, Gloria
name: Fyfe, Trina
name: Koopmans, Erica
name: Pousette, Anne
name: Pelletier, Chelsea A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Protocol
(500679) Sarah May
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Understanding physical literacy in the context of health: a rapid scoping review
Creators: name: Cornish, Katie
name: Fox, Gloria
name: Fyfe, Trina
name: Koopmans, Erica
name: Pousette, Anne
name: Pelletier, Chelsea A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 2. PRISMA-ScR checklist
The Social System Identification Problem
Creators: name: Wai, Hoi-To
name: Scaglione, Anna
name: Leshem, Amir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: The focus of this paper is modeling what we call a Social Radar, i.e. a method to estimate the relative influence between social agents, by sampling their opinions and as they evolve, after injecting in the network stubborn agents. The stubborn agents opinion is not influenced by the peers they seek to sway, and their opinion bias is the known input to the social network system. The novelty is in the model presented to probe a social network and the solution of the associated regression problem. The model allows to map the observed opinion onto system equations that can be used to infer the social graph and the amount of trust that characterizes the links.
description: Revised version submitted to IEEE CDC 2015, to be presented
Additional file 3 of Understanding physical literacy in the context of health: a rapid scoping review
Creators: name: Cornish, Katie
name: Fox, Gloria
name: Fyfe, Trina
name: Koopmans, Erica
name: Pousette, Anne
name: Pelletier, Chelsea A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 3. Search strategy