cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Upregulation of p53 through induction of MDM2 degradation: improved potency through the introduction of an alkylketone sidechain on the anthraquinone core
Creators: name: Tripathi, Ravi
name: Anifowose, Abiodun
name: Lu, Wen
name: Yang, Xiaoxiao
name: Wang, Binghe
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Overexpression of ubiquitin ligase MDM2 causes depletion of the p53 tumour-suppressor and thus leads to cancer progression. In recent years, anthraquinone analogs have received significant attention due to their ability to downregulate MDM2, thereby promoting p53-induced apoptosis. Previously, we have developed potent anthraquinone compounds having the ability to upregulate p53 via inhibition of MDM2 in both cell culture and animal models of acute lymphocytic leukaemia. Earlier work was focussed on mechanistic work, pharmacological validation of this class of compounds in animal models, and mapping out structural space that allows for further modification and optimisation. Herein, we describe our work in optimising the substituents on the two phenol hydroxyl groups. It was found that the introduction of an alkylketone moiety led to a potent series of analogs with BW-AQ-350 being the most potent compound yet (IC50 = 0.19 ± 0.01 µM) which exerts cytotoxicity by inducing MDM2 degradation and p53 upregulation.
High-field magnetization and magnetic phase diagram of $α$-Cu$_{2}$V$_{2}$O$_{7}$
Creators: name: Gitgeatpong, G.
name: Suewattana, M.
name: Zhang, Shiwei
name: Miyake, A.
name: Chanlert, P.
name: Kurita, N.
name: Tanaka, H.
name: Sato, T. J.
name: Zhao, Y.
name: Matan, K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: High-field magnetization of the spin-$1/2$ antiferromagnet $α$-Cu$_2$V$_2$O$_7$ was measured in pulsed magnetic fields of up to 56 T in order to study its magnetic phase diagram. When the field was applied along the easy axis (the $a$-axis), two distinct transitions were observed at $H_{c1}=6.5$~T and $H_{c2}=18.0$~T. The former is a spin-flop transition typical for a collinear antiferromagnet and the latter is believed to be a spin-flip transition of canted moments. The canted moments, which are induced by the Dzyaloshinskii-Moriya interactions, anti-align for $H_{c1}
title: In memoriam Emeterio Cuadrado Díaz (1907-2002)
title: In memoriam Emeterio Cuadrado Díaz (1907-2002)
titleType: Subtitle
Creators: name: Schubart, Hermanfrid
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Emeterio Cuadrado Díaz (1907-2002)
subject: Emeterio Cuadrado Díaz (1907-2002)

description: Madrider Mitteilungen, Vol. 44 (2003)
description: In memoriam Emeterio Cuadrado Díaz (1907-2002).
Preconditioner-free Wiener filtering with a dense noise matrix
Creators: name: Huffenberger, Kevin M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: This work extends the Elsner & Wandelt (2013) iterative method for efficient, preconditioner-free Wiener filtering to cases in which the noise covariance matrix is dense, but can be decomposed into a sum whose parts are sparse in convenient bases. The new method, which uses multiple messenger fields, reproduces Wiener filter solutions for test problems, and we apply it to a case beyond the reach of the Elsner & Wandelt (2013) method. We compute the Wiener filter solution for a simulated Cosmic Microwave Background map that contains spatially-varying, uncorrelated noise, isotropic $1/f$ noise, and large-scale horizontal stripes (like those caused by the atmospheric noise). We discuss simple extensions that can filter contaminated modes or inverse-noise filter the data. These techniques help to address complications in the noise properties of maps from current and future generations of ground-based Microwave Background experiments, like Advanced ACTPol, Simons Observatory, and CMB-S4.
description: 7 pages, 4 figures, submitted to MNRAS
Additional file 1 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Flow cytometry analysis of Eno-induced apoptosis. A Eno induced hCMEC/D3 apoptosis by flow cytometry in 24 h; B Eno induced 293T- cell apoptosis by flow cytometry in 24 h.
Unsupervised Steganalysis Based on Artificial Training Sets
Creators: name: Lerch-Hostalot, Daniel
name: Megías, David
Publisher: name: arXiv
Year: 2017
Subjects: subject: Multimedia (cs.MM)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In this paper, an unsupervised steganalysis method that combines artificial training setsand supervised classification is proposed. We provide a formal framework for unsupervisedclassification of stego and cover images in the typical situation of targeted steganalysis (i.e.,for a known algorithm and approximate embedding bit rate). We also present a completeset of experiments using 1) eight different image databases, 2) image features based on RichModels, and 3) three different embedding algorithms: Least Significant Bit (LSB) matching,Highly undetectable steganography (HUGO) and Wavelet Obtained Weights (WOW). Weshow that the experimental results outperform previous methods based on Rich Models inthe majority of the tested cases. At the same time, the proposed approach bypasses theproblem of Cover Source Mismatch -when the embedding algorithm and bit rate are known-, since it removes the need of a training database when we have a large enough testing set.Furthermore, we provide a generic proof of the proposed framework in the machine learningcontext. Hence, the results of this paper could be extended to other classification problemssimilar to steganalysis.
Unequal-Time Correlators for Cosmology
Creators: name: Kitching, T. D.
name: Heavens, A. F.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Measurements of the power spectrum from large-scale structure surveys have to date assumed an equal-time approximation, where the full cross-correlation power spectrum of the matter density field evaluated at different times (or distances) has been approximated either by the power spectrum at a fixed time, or in an improved fashion, by a geometric mean $P(k; r_1, r_2)=[P(k; r_1) P(k; r_2)]^{1/2}$. In this paper we investigate the expected impact of the geometric mean ansatz, and present an application in assessing the impact on weak gravitational lensing cosmological parameter inference, using a perturbative unequal-time correlator. As one might expect, we find that the impact of this assumption is greatest at large separations in redshift $Δz > 0.3$ where the change in the amplitude of the matter power spectrum can be as much as $10$ percent for $k > 5h$Mpc$^{-1}$. However, of more concern is that the corrections for small separations, where the clustering is not close to zero, may not be negligibly small. In particular, we find that for a Euclid- or LSST-like weak lensing experiment the assumption of equal-time correlators may result in biased predictions of the cosmic shear power spectrum, and that the impact is strongly dependent on the amplitude of the intrinsic alignment signal. To compute unequal-time correlations to sufficient accuracy will require advances in either perturbation theory to high $k$-modes, or extensive use of simulations.
description: 11 pages, 7 figures. Submitted to PRD
Additional file 2 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Screening and identification of Eno binding proteins in PBMECs based on LC/LC-MS and flow cytometry analysis. A, B Thirteen different proteins in protein bands between His-Eno and His tag groups were found by IP and LC/LC-MS; C pDisplay was a eukaryotic cell membrane-displayed vector. 293T cells were transfected with pDisplay::HSPD1, RPSA, JUP, TPM4, G3BP1, PTBP1, PGAM1, HH4, HSP90AB, RPS5, PHB, RPL11, and MYO1C, respectively. After 24 h, recombinant His-Eno was added to the culture dish to adhere the transfected cells. Mouse anti-His IgG was used, and flow cytometry was carried out to analyse the adhesion rate of Eno. Eno showed stronger adhesion to cells displaying RPSA and HSPD1 compared with that of the other experimental group and vector group (labeled “untreated”). We found Eno promoted HSPD1 secretion in PBMECs at 12 h by Enzyme Linked Immunosorbent Assay (ELISA). Knockdown RPSA inhibited HSPD1 secretion induced by Eno. In order to detect the effect of extracellular increased HSPD1 on PBMECs apoptosis. Experiments were designed as followed. The experiment was divided into five groups (n = 3). Remove Sup: PBMECs were treated by 0.5 uM Eno for 12 h and culture supernatant were removed. Fresh complete medium was added and cultured for another 12 h. antiE+antiH: PBMECs were treated by 0.5uM Eno for 12 h. Eno and HSPD1 antibodies was added and PBMECs were cultured for another 12 h. antiE: PBMECs were treated by 0.5 uM Eno for 12 h and Eno antibody was added and cultured for another 12 h. Enolase: PBMECs were treated by 0.5 uM Eno for 24h and analysed by flow cytometry. AntiControl: Negative isotype rabbit IgG was added into per well. All groups PBMECs were collected and analysed by flow cytometry.
title: Das Grab im Paradiesgarten. Zum Mausoleum der Nasridischen Sultane auf der Alhambra
title: Das Grab im Paradiesgarten. Zum Mausoleum der Nasridischen Sultane auf der Alhambra
titleType: Subtitle
Creators: name: Arnold, Felix
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
Creators: name: Elbadawi, Mostafa M.
name: Eldehna, Wagdy M.
name: El-Hafeez, Amer Ali Abd
name: Somaa, Warda R.
name: Albohy, Amgad
name: Al-Rashood, Sara T.
name: Agama, Keli K.
name: Elkaeed, Eslam B.
name: Ghosh, Pradipta
name: Pommier, Yves
name: Abe, Manabu
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: In this study, different assortments of 2-arylquinolines and 2,6-diarylquinolines have been developed. Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as Topoisomerase I (TOP1) inhibitors with potent anticancer activity. Utilising the SAR outputs from this study, we tried to enhance anticancer and TOP1 inhibitory activities. Though target quinolines demonstrated potent antiproliferative effect, specifically against colorectal cancer DLD-1 and HCT-116, they showed weak TOP1 inhibition which may be attributable to their non-coplanarity. Thereafter, screening against kinase panel revealed their dual inhibitory activity against EGFR and FAK. Quinolines 6f, 6h, 6i, and 20f were the most potent EGFR inhibitors (IC50s = 25.39, 20.15, 22.36, and 24.81 nM, respectively). Meanwhile, quinolines 6f, 6h, 6i, 16d, and 20f exerted the best FAK inhibition (IC50s = 22.68, 14.25, 18.36, 17.36, and 15.36 nM, respectively). Finally, molecular modelling was employed to justify the promising EGFR/FAK inhibition. The study outcomes afforded the first reported quinolines with potent EGFR/FAK dual inhibition.
title: Reiten auf Delphinen. Byzantinische Pressblechmodel für Sattel- und Zaumzeugbeschläge aus dem Nationalmuseum von Algier
title: Reiten auf Delphinen. Byzantinische Pressblechmodel für Sattel- und Zaumzeugbeschläge aus dem Nationalmuseum von Algier
titleType: Subtitle
Creators: name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Additional file 3 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Increased HSPD1 secretion induced by Eno promote PBMEC apoptosis. A Eno promote secretion ofHSPD1. B RPSA mediate Eno induced Increased HSPD1 secretion by RNAi assay. C and D Flow cytometry was used for extracellular increased HSPD1 promote PBMEC apoptosis. AntiControl, isotype rabbit IgG with Eno antibody/HSPD1 antibody; antiE, Eno antibody; antiH, HSPD1 antibody; Remove sup, culture supernatant were removed at 12 h post treated by Eno.
The Jain-2/5 parent Hamiltonian: structure of zero modes, dominance patterns, and zero mode generators
Creators: name: Chen, Li
name: Bandyopadhyay, Sumanta
name: Seidel, Alexander
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We analyze general zero mode properties of the parent Hamiltonian of the unprojected Jain-2/5 state. We characterize the zero mode condition associated to this Hamiltonian via projection onto a four-dimensional two-particle subspace for given pair angular momentum, for the disk and similarly for the spherical geometry. Earlier numerical claims in the literature about ground state uniqueness on the sphere are substantiated on analytic grounds, and related results are derived. Preference is given to second quantized methods, where zero mode properties are derived not from given analytic wave functions, but from a "lattice" Hamiltonian and associated zero mode conditions. This method reveals new insights into the guiding-center structure of the unprojected Jain-2/5 state, in particular a system of dominance patterns following a "generalized Pauli principle", which establishes a complete one-to-one correspondence with the edge mode counting. We also identify one-body operators that function as generators of zero modes.
Logarithmic connections on principal bundles over a Riemann surface
Creators: name: Biswas, Indranil
name: Dan, Ananyo
name: Paul, Arjun
name: Saha, Arideep
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 53B15, 14H60, 32A27

description: Let $E_G$ be a holomorphic principal $G$-bundle on a compact connected Riemann surface $X$, where $G$ is a connected reductive complex affine algebraic group. Fix a finite subset $D \subset X$, and for each $x\in D$ fix $w_x \in \text{ad}(E_G)_x$. Let $T$ be a maximal torus in the group of all holomorphic automorphisms of $E_G$. We give a necessary and sufficient condition for the existence of a $T$-invariant logarithmic connection on $E_G$ singular over $D$ such that the residue over each $x \in D$ is $w_x$. We also give a necessary and sufficient condition for the existence of a logarithmic connection on $E_G$ singular over $D$ such that the residue over each $x \in D$ is $w_x$, under the assumption that each $w_x$ is $T$-rigid.
Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation
Creators: name: Taghour, Mohammed S.
name: Mahdy, Hazem A.
name: Gomaa, Maher H.
name: Aglan, Ahmed
name: Eldeib, Mahmoud Gomaa
name: Elwan, Alaa
name: Dahab, Mohammed A.
name: Elkaeed, Eslam B.
name: Alsfouk, Aisha A.
name: Khalifa, Mohamed M.
name: Eissa, Ibrahim H.
name: Elkady, Hazem
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for their VEGFR-2 inhibitory activities. The most potent anti-proliferative member 12 l (IC50 = 10.50 μM and 15.21 μM against HepG2 and MCF-7, respectively) had the most promising VEGFR-2 inhibitory activity (IC50 = 97.38 nM). A further biological evaluation revealed that compound 12l could arrest the HepG2 cell growth mainly at the Pre-G1 and G1 phases. Furthermore, compound 12l could induce apoptosis in HepG2 cells by 35.13%. likely, compound 12l exhibited a significant elevation in caspase-3 level (2.98-fold) and BAX (3.40-fold), and a significant reduction in Bcl-2 level (2.12-fold). Finally, docking studies indicated that 12l exhibited interactions with the key amino acids in a similar way to sorafenib.
title: El Puente de Arroyo Pedroches (Córdoba). Estudio arqueológico
title: El Puente de Arroyo Pedroches (Córdoba). Estudio arqueológico
titleType: Subtitle
Creators: name:  Ferrer Albelda, Eduardo
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
Liquid droplets act as "compass needles" for the stresses in a deformable membrane
Creators: name: Schulman, Rafael D.
name: Ledesma-Alonso, René
name: Salez, Thomas
name: Raphaël, Elie
name: Dalnoki-Veress, Kari
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We examine the shape of droplets atop deformable thin elastomeric films prepared with an anisotropic tension. As the droplets generate a deformation in the taut film through capillary forces, they assume a shape that is elongated along the high tension direction. By measuring the contact line profile, the tension in the membrane can be completely determined. Minimal theoretical arguments lead to predictions for the droplet shape and membrane deformation that are in excellent agreement with the data. On the whole, the results demonstrate that droplets can be used as probes to map out the stress field in a membrane.
title: Ein römisches Relief aus Vilarín (Becerreá, Lugo)
title: Ein römisches Relief aus Vilarín (Becerreá, Lugo)
titleType: Subtitle
Creators: name: Suárez Otero,  José
name:  	Caramés Moreira, Vicente
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Metrology for Drug Delivery II: a new joint research project for metrology in healthcare
Creators: name: Batista, Elsa
name: Furtado, Andreia
name: Pereira, Jorge
name: Ferreira, Maria Do Céu
name: Bissig, Hugo
name: Emmelyn Graham
name: Niemann, Anders
name: Annemoon Timmerman
name: Ogheard, Florestan
Publisher: name: Zenodo
Year: 2019
Subjects: Drug delivery device, metrology, accuracy

description: This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project - MeDD II, Metrology for drug delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project starts in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (for example infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line
Additional file 4 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Screening of the signalling pathway(s) activated by Eno-RPSA interaction based on proteomics analysis. A Cytoplasmic phosphorylated proteomics analysis of Eno-stimulated PBMEC for 24 h; B Nuclear proteomics analysis of Eno-stimulated PBMEC for 24 h. EIF4A2, EIF4E2, and EIF3J, the EIF family proteins, were increased in Eno-treated PBMECs (indicated as red) compared with the untreated PBMEC control (indicated as grey).
title: La Edad del Hierro en la Meseta Occidental
title: La Edad del Hierro en la Meseta Occidental
titleType: Subtitle
Creators: name: Álvarez-Sanchís, Jesús
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
title: La dorsal gallega como barrera intracultural durante la Edad del Hierro
title: La dorsal gallega como barrera intracultural durante la Edad del Hierro
titleType: Subtitle
Creators: name:  Carballo Arceo, Luis Xulio
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
Guidelines for citing library-hosted, unique digital assets
Creators: name: Kelly, Elizabeth
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: assessment
subject: citation
subject: digital libraries
subject: DLF
subject: DLF AIG

description: These draft guidelines were developed in response to a call for steps forward made by the Digital Library Federation (DLF) Assessment subgroup on Benefits. One of the 1 areas identified for development included the establishment of best practices and guidelines for citing digital libraries.
title: Reflexions sur la sculpture funéraire et votive du Sud-Est de la Péninsule Ibérique
title: Reflexions sur la sculpture funéraire et votive du Sud-Est de la Péninsule Ibérique
titleType: Subtitle
Creators: name: Truszkowski, Elisabeth
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties
Creators: name: Stankiewicz, Anna
name: Kaczorowska, Katarzyna
name: Bugno, Ryszard
name: Kozioł, Aneta
name: Paluchowska, Maria H.
name: Burnat, Grzegorz
name: Chruścicka, Barbara
name: Chorobik, Paulina
name: Brański, Piotr
name: Wierońska, Joanna M.
name: Duszyńska, Beata
name: Pilc, Andrzej
name: Bojarski, Andrzej J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectivity screening revealed that they were devoid of activity at mGlu1, mGlu2 and mGlu5 receptors, but modulated mGlu7 and mGlu8 receptors, thus were classified as group III-preferring mGlu receptor agents. None of the compounds was active towards hERG channels or in the mini-AMES test. The most potent in vitro mGlu4 PAM derivative 52 (N-(3-chloro-4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)phenyl)picolinamide) was readily absorbed after i.p. administration (male Albino Swiss mice) and reached a maximum brain concentration of 949.76 ng/mL. Five modulators (34, 37, 52, 60 and 62) demonstrated significant anxiolytic- and antipsychotic-like properties in the SIH and DOI-induced head twitch test, respectively. Promising data were obtained, especially for N-(4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)picolinamide (62), whose effects in the DOI-induced head twitch test were comparable to those of clozapine and better than those reported for the selective mGlu4 PAM ADX88178.
title: Guerreros galaicos – Sculpture laténienne. En guise de conclusion
title: Guerreros galaicos – Sculpture laténienne. En guise de conclusion
titleType: Subtitle
Creators: name: Szabó ,  Miklós
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
Additional file 5 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Construction of the mouse model with knockdown RPSA and/or HSPD1 in the brain. A Two months after the third ventricle injection, frozen slices of the brain showed that AAV, which carried mCherry-RPSA or GFP-HSPD1, is distributed throughout the brain. Control AAV-shRNA (shControl) carried GFP (scale bar, 2000 μm); B Western blotting showed that the knockdown RPSA and/or HSPD1 model of the mouse brain was successfully established two months after the third ventricle injection by AAV, which carried mCherry-RPSA or GFP-HSPD1.
Neutral Gas Accretion onto Nearby Galaxies
Creators: name: Lockman, Felix J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: While there is no lack of evidence for the accretion of stellar systems onto nearby galaxies, direct evidence for the accretion of gas without stars is scarce. Here we consider an inventory of starless gas "clouds" in and around galaxies of the Local Group to discern their general properties and see how they might appear in distant systems. The conclusion is that accreting gas without stars is detected almost entirely within the circumgalactic medium of large galaxies and is rare otherwise. If our Local Group is any example, the best place to detect starless gas clouds is relatively close to galaxies.
description: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springer
Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors
Creators: name: Yan, Longjia
name: Wang, Qin
name: Liu, Li
name: Le, Yi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) and three tumour cells, including A549, PC-3, and HepG2. Some of the compounds performed well in antitumor activities. Especially, compound 4c 2-((2-((4-(3-fluorobenzamido)phenyl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)amino)-N-methylthiophene-3-carboxamide showed higher anti-tumour activities than Gefitinib. The IC50 values of compound 4c against A549, PC-3, and HepG2. reached 0.56 μM, 2.46 μM, and 2.21 μM, respectively. In addition, further studies indicated that compound 4c could induce apoptosis against A549 cells and arrest A549 cells in the G2/M phase. Molecular docking studies showed that compound 4c could closely interact with EGFR. Generally, compound 4c was the potential for developing into an anti-tumour drug.
title: Where have all the Warriors Gone? Some Aspects of Stone Sculpture from Britain to Bohemia
title: Where have all the Warriors Gone? Some Aspects of Stone Sculpture from Britain to Bohemia
titleType: Subtitle
Creators: name: Megaw, John Vincent Stanley
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: The image of the ancient Celts as painted both by our Classical sources and modern popular myth is, in Stuart Piggott’s words, that of «swaggering, belching, touchy chieftains and their equally impossible warrior crew, hands twitching to the sword-hilt at the imagined hint of an insult» (Piggott 1965, 229). While we need not prolong the debate concerning the very existence of an ancient ‘Celtic’ culture, it is clear that in terms of archaeological material, there existed in Europe prior to the establishment of the Roman Empire, a number of disparate and definable local communities, linked in part at least by language and, over arching all, a common belief system and visual vocabulary. It should come as no surprise that certain regions lack, in terms of sculpture, visible evidence of this warrior society. In surveying the scanty examples from the British Isles and Ireland on the one hand and Bohemia on the other, this paper not only underscores the lack of warrior statues but illustrates how rare outside Iberia are any representations of warriors from the main area of La Tène culture in western and central Europe. In contrasting this lacuna with the widespread evidence for socalled ‘warrior’ graves of the fifth to second century BC, the paper briefly discusses the rôle played by such ‘warriors’.
Additional file 6 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Verification of mechanism of Eno induced apoptosis in mice. Intravenous injection of Eno or SS2 promoted the expression of apoptosis-related molecules in mouse brains by immunohistochemical analysis (*p < 0.05, **p < 0.01) (scale bar, 100 μm).
Gas Accretion and Star Formation Rates
Creators: name: Almeida, J. Sanchez
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Cosmological numerical simulations of galaxy evolution show that accretion of metal-poor gas from the cosmic web drives the star formation in galaxy disks. Unfortunately, the observational support for this theoretical prediction is still indirect, and modeling and analysis are required to identify hints as actual signs of star-formation feeding from metal-poor gas accretion. Thus, a meticulous interpretation of the observations is crucial, and this observational review begins with a simple theoretical description of the physical process and the key ingredients it involves, including the properties of the accreted gas and of the star-formation that it induces. A number of observations pointing out the connection between metal-poor gas accretion and star-formation are analyzed, specifically, the short gas consumption time-scale compared to the age of the stellar populations, the fundamental metallicity relationship, the relationship between disk morphology and gas metallicity, the existence of metallicity drops in starbursts of star-forming galaxies, the so-called G dwarf problem, the existence of a minimum metallicity for the star-forming gas in the local universe, the origin of the alpha-enhanced gas forming stars in the local universe, the metallicity of the quiescent BCDs, and the direct measurements of gas accretion onto galaxies. A final section discusses intrinsic difficulties to obtain direct observational evidence, and points out alternative observational pathways to further consolidate the current ideas.
description: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springer
title: A Historico-geographical approach of Fringe-Belt Phenomena  in Kadıköy, Istanbul
Creators: name: Hafizoğlu, Eda
name: Kubat, Ayşe Sema
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/ Lodz University of Technology Press
Year: 2023
Subjects: Urban morphology, Fringe-belts, Urban growth, Istanbul, Kadıköy.

description: Fringe-belts are significant in determining the spatial growth cycles and relationships of poly-centric cities such as Istanbul, where rapid urbanization accelerated with the land use changes. Kadıköy, located on the Anatolian side of Istanbul, is not only a primary transfer and cultural center and secondary central business area, but also a primary urban transformation area today. While Kadıköy, which formed the outer fringe-belt of Istanbul until the mid-1800s, completed its spatial development on the basis of the building block in the 1990s; it has been going through a renewal process on the building scale for the last 20 years. This study targets the analysis of the formation and modification of fringe-belts in Kadıköy's historical settlement area and its immediate surroundings with direct/indirect actors in a historico-geographical approach. Concordantly, the ‘fringe-belt theory’ constitutes the methodology of the study. The land utilizations of fringe-belts in Kadıköy are analyzed comparatively by overlapping the historical city map, periodic satellite images and zoning plan; and the results are also digitized. The findings, while revealing whether fringe-belts should be recognized in urban policy-making and planning for megacities with historical and natural heritages, question the role of fringe-belts within the scope of ongoing and future urban projects.
Additional file 7 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: 13 Proteins suspected to interact with Eno.
title: De Roquepertuse à Entremont... La grande sculpture du midi de la Gaule
title: De Roquepertuse à Entremont... La grande sculpture du midi de la Gaule
titleType: Subtitle
Creators: name: Rapin, André
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Les nouvelles lectures de l’iconographie des sculptures de Gaule méridionale ont entraîné de profonds remaniements de sa chronologie. Les plus anciennes de ces figurations de guerriers semblent être contemporaines du début du premier âge du Fer. Entre VIIe et VIe siècle, elles se concentrent dans le Languedoc nord-oriental dans la vallée du Gard. Le thème du guerrier assis, équipé d’une cuirasse spécifique des Celtes semblable à celles des guerriers de Glauberg, apparaît dans la région de Nîmes. L’évolution stylistique de ces figurations révèle que les sculpteurs indigènes s’émancipent rapidement des influences helléniques archaïques. Le terme de cette évolution vers une plastique plus celtique que grecque semble atteint à Roquepertuse près de Marseille dès le Ve siècle. Il faudra attendre le IIIe siècle pour que cette tradition lapidaire, probablement funéraire, reprenne à Entremont.
Precision Luminosity of LHC Proton-Proton Collisions at 13 TeV Using Hit-Counting with TPX Pixel Devices
Creators: name: Sopczak, Andre
name: Ali, Babar
name: Asawatavonvanich, Thanawat
name: Begera, Jakub
name: Bergmann, Benedikt
name: Billoud, Thomas
name: Burian, Petr
name: Caicedo, Ivan
name: Caforio, Davide
name: Heijne, Erik
name: Janecek, Josef
name: Leroy, Claude
name: Manek, Petr
name: Mochizuki, Kazuya
name: Mora, Yesid
name: Pacik, Josef
name: Papadatos, Costa
name: Platkevic, Michal
name: Polansky, Stepan
name: Pospisil, Stanislav
name: Suk, Michal
name: Svoboda, Zdenek
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: A network of Timepix (TPX) devices installed in the ATLAS cavern measures the LHC luminosity as a function of time as a stand-alone system. The data were recorded from 13 TeV proton-proton collisions in 2015. Using two TPX devices, the number of hits created by particles passing the pixel matrices was counted. A van der Meer scan of the LHC beams was analysed using bunch-integrated luminosity averages over the different bunch profiles for an approximate absolute luminosity normalization. It is demonstrated that the TPX network has the capability to measure the reduction of LHC luminosity with precision. Comparative studies were performed among four sensors (two sensors in each TPX device) and the relative short-term precision of the luminosity measurement was determined to be 0.1% for 10 s time intervals. The internal long-term time stability of the measurements was below 0.5% for the data-taking period.
description: Presented at the IEEE 2016 Nuclear Science Symposium, Strasbourg, France
Additional file 8 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Creators: name: Liu, Hongtao
name: Lei, Siyu
name: Jia, Li
name: Xia, Xiaojing
name: Sun, Yingying
name: Jiang, Hexiang
name: Zhu, Rining
name: Li, Shuguang
name: Qu, Guanggang
name: Gu, Jingmin
name: Sun, Changjiang
name: Feng, Xin
name: Han, Wenyu
name: Langford, Paul R.
name: Lei, Liancheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: siRNA used for RPSA and HSPD1 knockdown.
title: Die Statuen vom Glauberg in ihrem Fundzusammenhang
title: Die Statuen vom Glauberg in ihrem Fundzusammenhang
titleType: Subtitle
Creators: name: Herrmann, Fritz-Rudolf
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Decoding Small Surface Codes with Feedforward Neural Networks
Creators: name: Varsamopoulos, Savvas
name: Criger, Ben
name: Bertels, Koen
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Surface codes reach high error thresholds when decoded with known algorithms, but the decoding time will likely exceed the available time budget, especially for near-term implementations. To decrease the decoding time, we reduce the decoding problem to a classification problem that a feedforward neural network can solve. We investigate quantum error correction and fault tolerance at small code distances using neural network-based decoders, demonstrating that the neural network can generalize to inputs that were not provided during training and that they can reach similar or better decoding performance compared to previous algorithms. We conclude by discussing the time required by a feedforward neural network decoder in hardware.
Additional file 1 of RETRACTED ARTICLE: The role of seed appendage in improving the adaptation of a species in definite seasons: a case study of Atriplex centralasiatica
Creators: name: Wang, Zhaoren
name: Zhao, Yufei
name: Zhang, Yuanyuan
name: Zhao, Baoshan
name: Yang, Zhen’an
name: Dong, Lijia
Publisher: name: figshare
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1: Table S1. Mass, moisture content, and morphological characteristics types A, B and C diaspores and seeds of Atriplex centralasiatica (mean ± SE).
Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents
Creators: name: Xue, Wenjie
name: Wang, Yaling
name: Lian, Xu
name: Li, Xueyao
name: Pang, Jing
name: Kirchmair, Johannes
name: Wu, Kebin
name: Han, Zunsheng
name: You, Xuefu
name: Zhang, Hongmin
name: Xia, Jie
name: Wu, Song
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective against drug-resistant bacteria, such as methicillin-resistant S. aureus (MRSA). Here, we used the 4-hydroxy-2-quinolone fragment to search the Specs database of purchasable compounds for potential inhibitors of GyrB and identified AG-690/11765367, or f1, as a novel and potent inhibitor of the target protein (IC50: 1.21 µM). Structural modification was used to further identify two more potent GyrB inhibitors: f4 (IC50: 0.31 µM) and f14 (IC50: 0.28 µM). Additional experiments indicated that compound f1 is more potent than the others in terms of antibacterial activity against MRSA (MICs: 4–8 µg/mL), non-toxic to HUVEC and HepG2 (CC50: approximately 50 µM), and metabolically stable (t1/2: > 372.8 min for plasma; 24.5 min for liver microsomes). In summary, this study showed that the discovered N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides are novel GyrB-targeted antibacterial agents; compound f1 is promising for further development.