cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of geometric variations on delivered dose in highly focused single vocal cord IMRT
Creators: name: Osman, Sarah O. S.
name: Astreinidou, Eleftheria
name: Levendag, Peter C.
name: Heijmen, Ben J. M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Purpose. To investigate the robustness of single vocal cord intensity modulated radiation therapy (IMRT) treatment plans for set-up errors, respiration, and deformation. Material and methods. Four-dimensional computed tomography (4D-CT) scans of 10 early glottic carcinoma patients, previously treated with conventional techniques, were used in this simulation study. For each patient a pre-treatment 4D-CT was used for IMRT planning, generating a reference dose distribution. Prescribed PTV dose was 66 Gy. The impact of systematic set-up errors was simulated by applying shifts of ± 2 mm to the planning CT scans, followed by dose re-calculation with original beam segments, MUs, etc. Effects of respiration and deformation were determined utilizing extreme inhale and exhale CT scans, and repeat scans acquired after 22 Gy, 44 Gy, and 66 Gy, respectively. All doses were calculated using Monte Carlo dose simulations. Results. Considering all investigated geometrical perturbations, reductions in the clinical target volume (CTV) V95%, D98%, D2%, and generalized equivalent uniform dose (gEUD) were limited to 1.2 ± 2.2%, 2.4 ± 2.9%, 0.2 ± 1.8%, and 0.6 ± 1.1 Gy, respectively. The near minimum dose, D98%, was always higher than 89%, and gEUD always remained higher than 66 Gy. Planned contra-lateral (CL) vocal cord DMean, gEUD, and V40 Gy were 38.2 ± 6.0 Gy, 43.4 ± 5.6 Gy, and 42.7 ± 14.9%. With perturbations these values changed by −0.1 ± 4.3 Gy, 0.1 ± 4.0 Gy, and −1.0 ± 9.6%, respectively. Conclusions. On average, CTV dose reductions due to geometrical perturbations were very low, and sparing of the CL vocal cord was maintained. In a few observations (6 of 103 simulated situations), the near-minimum CTV-dose was around 90%, requiring attention in deciding on a future clinical protocol.
title: 03_0154
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: Changes in Electronic Structure and Chemical Bonding upon Crystallization of the Phase Change Material GeSb₂Te₄
Creators: name: Klein, Andreas
name: Dieker, H.
name: Späth, B.
name: Fons, P.
name: Kolobov, A.
name: Steimer, C.
name: Wuttig, M.
Publisher: name: American Physical Society
Year: 2022

description: High-resolution photoelectron spectroscopy of in situ prepared films of GeSb₂Te₄ reveals significant differences in electronic and chemical structure between the amorphous and the crystalline phase. Evidence for two different chemical environments of Ge and Sb in the amorphous structure is found. This observation can explain the pronounced property contrast between both phases and provides new insight into the formation of the amorphous state.
PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced breast cancer patients
Creators: name: Nielsen, Torsten O.
name: Liu, ShuZhen
name: Wallden, Brett
name: Nielsen, Dorte L.
name: Ejlertsen, Bent
name: Jørgensen, Charlotte L. T.
name: Bjerre, Karsten D.
name: Balslev, Eva
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Cancer
Biological Sciences
Biotechnology
Pharmacology
Cell Biology
Medicine

description: Background. In vitro studies suggest basal breast cancers are more sensitive to gemcitabine relative to other intrinsic subtypes. The main objective of this study was to use specimens from a randomized clinical trial to evaluate whether the basal-like subtype identifies patients with advanced breast cancer who benefit from gemcitabine plus docetaxel (GD) compared to single agent docetaxel (D).Material and methods. From patients randomly assigned to GD or D, RNA was isolated from archival formalin-fixed, paraffin-embedded primary breast tumor tissue and used for PAM50 intrinsic subtyping by NanoString nCounter. Statistical analyses were prespecified as a formal prospective-retrospective clinical trial correlative study. Using time to progression (TTP) as primary endpoint, overall survival (OS) and response rate as secondary endpoints, relationships between subtypes and outcome after chemotherapy were analyzed by the Kaplan-Meier method, and Cox proportional hazards regression models. Data analysis was performed independently by the Danish Breast Cancer Cooperative Group (DBCG) statistical core and all statistical tests were two-sided.Results. RNA from 270 patients was evaluable; 84 patients (31%) were classified as luminal A, 97 (36%) luminal B, 43 (16%) basal-like, and 46 (17%) as HER2-enriched. PAM50 intrinsic subtype was a significant independent prognostic factor for both TTP (p = 0.014) and OS (p = 0.0003). Response rate was not different by subtype, and PAM50 was not a predictor of TTP by treatment arm. PAM50 was however a highly significant predictor of OS following GD compared to D (pinteraction = 0.0016). Patients with a basal-like subtype had a significant reduction in OS events [hazard ratio (HR) = 0.29, 95% confidence interval (CI) = 0.15–0.57; pinteraction = 0.0006].Conclusion. A significantly improved and clinically important prolongation of survival was seen from the addition of gemcitabine to docetaxel in advanced basal-like breast cancer patients.
Towards a Pattern Language for Sound and Music Computing
Creators: name: Arumi, Pau
Publisher: name: Zenodo
Year: 2006

description: Sound and music computing is all about. . . computing. But despite the large number of reusable software components and models-of-computation available for this domain, audio developers face new problems all the time. Most often, however, the same or similar problems have already been solved by others, but they lack the means for reusing those solutions. This dissertation proposes a design pattern language for data-flow systems: a technique that bridges the gap between the type of functionality provided by libraries and data-flow frameworks, on one side, and data-flow models-of-computation, on the other. The problem with libraries is that they often are too specific. Frameworks cover a broader scope but often overlimiting how to do things. On the other hand, the data-flow models-of-computation favors analysis versus design and implementation. A pattern is a proved solution to a recurring design problem. It pays special attention to the context in which it is applicable, to the competing “forces” it needs to balance, and the consequences of its application. A pattern language, moreover, suggests a sequence of patterns to be applied depending on the current context. Patterns provide a better solution when the focus is on customizing a new design on an existing code. However, neither data-flow systems nor other audio-related areas have yet received relevant additions of domain specific patterns. We demonstrate that the proposed catalog provides useful design reuse in the audio domain, and we show that they can be found in many different applications. As an example, we present the design of an object-oriented framework that uses all the patterns. We also show that patterns are useful to communicate, document and compare designs of audio systems. We believe that the incorporation of pattern-driven design will allow audio software to “grow up” out of the craftsman state and into a more mature state
title: Electronically Decoupled Films of InSe Prepared by van der Waals Epitaxy: Localized and Delocalized Valence States
Creators: name: Klein, Andreas
name: Lang, O.
name: Schlaf, R.
name: Pettenkofer, C.
name: Jaegermann, Wolfram
Publisher: name: American Physical Society
Year: 2022

description: Submonolayer to several monolayer thick films of the layered semiconductor InSe were deposited on highly oriented pyrolytic graphite by van der Waals epitaxy and probed by energy dependent angle resolved photoelectron spectroscopy. The layers show a transition from two-dimensional bands with atomiclike states to molecularlike states localized along the c direction normal to the surface. The extended band structure showing band dispersion was observed for thicker films.
Pathway to Diversity in STEM Review
Creators: name: Harvey-Smith, Lisa
name: Bergman, Jessica
name: Williams, Lisa A.
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: What evidence exists on the effectiveness of initiatives that might retain and progress women in STEM careers? The goal of this review activity is to synthesize the results of studies that evaluate macro-scale equity initiatives to summarize what works and doesn’t work. While there is a breadth of information on initiatives attracting women to STEM degrees and careers, there is limited information on initiatives that retain and progress women once they have entered the workforce. Having a clear data-driven understanding of the types of initiatives that are effective and those that are not can support the planning of interventions to tackle inequities and improve STEM workforce diversity. This review will focus on initiatives that are implementable at the workforce level (e.g., leadership representation, pay gap reduction) that address gender equity either in their design or in outcomes.
Systematic underreporting of the population-based incidence of pancreatic and biliary tract cancers
Creators: name: Mattsson, Fredrik
name: Ljung, Rickard
name: Lagergren, Jesper
name: Kilander, Carl
name: Sadr-Azodi, Omid
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine

description: Background. Incidence rates of cancers of the pancreas and biliary tract, typically derived from cancer registers, have been reported to be decreasing. This study tested whether pancreatic and biliary tract cancers are underreported in the Swedish Cancer Register (CR). Methods. The concordance of pancreatic and biliary tract cancer diagnoses in 1990–2009 between CR and the Swedish Patient Register (PR) were evaluated through record linkage. To further assess the completeness of these cancer diagnoses in both CR and PR, record linkage was also made to the Swedish Causes of Death Register (DR). Results. A total of 31 067 cases of pancreatic cancer and 14 273 cases of biliary tract cancer were identified in CR or PR. Altogether, 44% of the pancreatic cancers and 44% of the biliary tract cancers were registered in PR only, and not in CR. The concordance between CR and PR declined from 63% in the years 1990–1994 to 44% in 2005–2009 for pancreatic cancer. The corresponding figures for biliary tract cancer were 60% and 37%. This decline in concordance was also observed with increasing age, e.g. the concordance between CR and PR for pancreatic cancer declined from 62% in patients < 60 years to 36% among patients ≥ 80 years. The corresponding figures for biliary tract cancer were 52% and 38%. Conclusion. There is an overwhelming underreporting of pancreatic and biliary tract cancers within the Swedish Cancer Register, which has increased during recent years. The reported decreasing incidence rates for pancreatic and biliary tract cancers might therefore be incorrect.
title: Nature of the Band Gap of In₂O₃ Revealed by First-Principles Calculations and X-Ray Spectroscopy
Creators: name: Walsh, Aron
name: Silva, Juarez L. F. Da
name: Wei, Su-Huai
name: Körber, C.
name: Klein, Andreas
name: Piper, L. F. J.
name: DeMasi, Alex
name: Smith, Kevin E.
name: Panaccione, G.
name: Torelli, P.
name: Payne, D. J.
name: Bourlange, A.
name: Egdell, R. G.
Publisher: name: American Physical Society
Year: 2022

description: Bulk and surface sensitive x-ray spectroscopic techniques are applied in tandem to show that the valence band edge for In₂O₃ is found significantly closer to the bottom of the conduction band than expected on the basis of the widely quoted bulk band gap of 3.75 eV. First-principles theory shows that the upper valence bands of In₂O₃ exhibit a small dispersion and the conduction band minimum is positioned at Γ. However, direct optical transitions give a minimal dipole intensity until 0.8 eV below the valence band maximum. The results set an upper limit on the fundamental band gap of 2.9 eV.
Dose calculation and treatment plan optimization including imaging dose from kilovoltage cone beam computed tomography
Creators: name: Parham Alaei
name: Spezi, Emiliano
name: Reynolds, Margaret
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Hematology
Cancer
Cell Biology
Medicine
Physics
Engineering
Biophysics

description: Background. With the increasing use of cone beam computed tomography (CBCT) for patient position verification and radiotherapy treatment adaptation, there is an increasing need to develop techniques that can take into account concomitant dose using a personalized approach.Material and methods. A total of 20 patients (10 pelvis and 10 head and neck) who had undergone radiation therapy using intensity modulated radiation therapy (IMRT) were selected and the dose from kV CBCT was retrospectively calculated using a treatment planning system previously commissioned for this purpose. The imaging dose was added to the CT images used for treatment planning and the difference in its addition prior to and after the planning was assessed.Results. The additional isocenter dose as a result of daily CBCT is in the order of 3–4 cGy for 35-fraction head and neck and 23–47 cGy for 25-fraction pelvis cases using the standard head and neck and pelvis image acquisition protocols. The pelvic dose is especially dependent on patient size and body mass index (BMI), being higher for patients with lower BMI. Due to the low energy of the kV CBCT beam, the maximum energy deposition is at or near the surface with the highest dose being on the patient's left side for the head and neck (∼ 7 cGy) and on the posterior for the pelvic cases (∼ 80 cGy). Addition of imaging dose prior to plan optimization resulted in an average reduction of 4% in the plan monitor units and 5% in the number of control points.Conclusion. Dose from daily kV CBCT has been added to patient treatment plans using previously commissioned kV CBCT beams in a treatment planning system. Addition of imaging dose can be included in IMRT treatment plan optimization and would facilitate customization of imaging protocol based on patient anatomy and location of isocenter.
MANAGEMENT OF PATIENTS WITH COMPLEX RECTAL FISTULAS
Creators: name: Sherkulov, Kodir
name: Atoyeva, Mokhigul
name: Usmonov, Amirbek
name: Usmonkulov, Ma`rufjon
Publisher: name: Zenodo
Year: 2024

description: Today, if we talk not about a single universal method, but about the development of a certain direction, approach to the treatment of rectal fistula, there are significant positive changes [1, 2, 4, 6]. Thus, since the end of the last century, against the background of the development of medical technology began to appear and actively develop methods of treatment of rectal fistula, in which the sphincter apparatus is not directly affected [3, 5, 7].
title: Polarization dependence of ZnO Schottky barriers revealed by photoelectron spectroscopy
Creators: name: Wendel, Philipp
name: Periyannan, Shanmugapriya
name: Jaegermann, Wolfram
name: Klein, Andreas
Publisher: name: American Physical Society
Year: 2022

description: In order to answer the question of whether Schottky barriers on polar ZnO surfaces are different at Zn- and O-terminated surfaces, the interface formation of n-type ZnO and different high work function metals and metal oxides (Pt, PtOₓ, and RuO₂) with Schottky barrier heights of up to 1.5 eV has been studied using photoelectron spectroscopy with in situ sample preparation. The experiments are designed to exclude the effects of substrate reduction and consequent Fermi level pinning by high concentrations of oxygen vacancies. Moreover, by including the Zn LMM Auger emission in the analysis, it is demonstrated that an accurate extraction of barrier heights needs to take into account that the screening of the photoelectron core hole can change in the course of contact formation. The polarization dependence of Schottky barriers, which is important for piezotronic applications, is in most cases dominated by the influence of defects. Reducing the influence of defects, up to ∼240 meV higher Schottky barriers are revealed on oxygen-terminated surfaces. This is opposite to what has been reported in the literature but agrees with the dependence of barrier heights expected for an incomplete screening of the polarization of ZnO by the electrode as for ferroelectric materials.
IN03172 Anurādhapura Stone Steps near 'Burrows' Pavilion' Inscription 1
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03172
Epigraphia Zeylanica
Anuradhapura

description: IN03172 Anurādhapura Stone Steps near ‘Burrows’ Pavilion’ Inscription 1 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 16. Inscriptions on the Steps near ‘Burrows’ Pavilion’ at Anurādhapura,’ Epigraphia Zeylanica 4, pp. 136–141.
title: Искусственный интеллект: нечисловая статистика
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебнике впервые систематически рассмотрена важная составляющая искусственного интеллекта — сердцевина высоких статистических технологий, одна из четырех основных областей современной прикладной математической статистики — нечисловая статистика. Она порождена потребностями прикладных социально-экономических, технических и медико-биологических исследований. В издании раскрыты основные виды нечисловых данных, методология, процедуры и особенности их статистического анализа. Представлены статистические методы в пространствах произвольной природы, статистика нечисловых данных конкретных видов, статистика интервальных данных. Большое внимание уделяется проблемам практического применения методов и результатов нечисловой статистики. Подготовлен в соответствии с требованиями Федерального государственного образовательного стандарта высшего образования. Учебник рекомендуется к использованию студентам при изучении таких дисциплин, как «Прикладная статистика», «Эконометрика», «Организационно-экономическое моделирование», «Методы принятия управленческих решений», «Математические модели микроэкономики», «Математические модели макроэкономики» по направлениям подготовки 02.03.01 «Математика и компьютерные науки», 27.03.05 «Инноватика», 38.03.01 «Экономика», 38.03.02 «Менеджмент». Книга представляет интерес также для исследователей современных статистических методов в технике, экономике, управлении, медицине, социологии и иных областях, а также для разработчиков таких методов и соответствующего программного обеспечения.
title: Искусственный интеллект: cтатистические методы анализа данных
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебник посвящен современным методам анализа статистических данных. В первой части рассмотрены основы выборочных исследований и основные задачи описания данных, оценивания и проверки гипотез. Статистические методы анализа числовых данных, многомерный статистический анализ и статистические методы анализа динамики обсуждаются во второй части с непараметрической точки зрения. Основные понятия теории статистического моделирования раскрываются в третьей части на примерах моделей экономики и управления (управления качеством, логистики, взаимовлияния факторов), экспертных исследований, медицины, социологии, демографии, истории, электротехники. Теоретическим инструментам, истории и перспективам развития статистических методов посвящена четвертая часть. Изложение соответствует рекомендациям Российской академии статистических методов. Подготовлен с учетом требований Федерального государственного образовательного стандарта высшего образования. Для студентов и преподавателей вузов, слушателей институтов повышения квалификации, структур второго образования и программ МВА («Мастер делового администрирования»), инженеров различных специальностей, менеджеров, экономистов, социологов, научных и практических работников, связанных с анализом данных.
title: Искусственный интеллект: экспертные оценки
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебник посвящен основным вопросам теории и практики экспертных оценок, в том числе связанным с типовыми стадиями экспертного опроса, методами подбора экспертов, разработкой регламентов проведения сбора и анализа экспертных мнений. Рассмотрены основные идеи современной теории измерений, метода согласования кластеризованных ранжировок, теории нечеткости и ряда других математических и статистических методов анализа экспертных оценок. Обсуждаются применения экспертных оценок в экономике и менеджменте, экологии, при оценке рисков и построении рейтингов, при прогнозировании и управлении качеством. Подготовлен с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебник рекомендуется к использованию студентам при изучении таких дисциплин, как «Организационно-экономическое моделирование», «Методы принятия управленческих решений», «Эконометрика», «Экономико-математические методы и модели» по направлениям подготовки бакалавриата 02.03.01 «Математика и компьютерные науки», 27.03.05 «Инноватика», 38.03.01 «Экономика», 38.03.02 «Менеджмент» и магистратуры 27.04.06 «Организация и управление наукоемкими производствами». Книга представляет интерес также для исследователей и преподавателей современных методов сбора и анализа экспертных данных и искусственного интеллекта в технике, экономике, управлении, медицине, экологии, социологии и иных областях, а также для разработчиков таких методов и соответствующего программного обеспечения.
Tracing 600 years of long-distance Atlantic cod trade in medieval and post-medieval Oslo using stable isotopes and ancient DNA
Creators: name: Martínez-García, Lourdes
name: Pulido, Angélica
name: Ferrari, Giada
name: Hufthammer, Anne Karin
name: Vedeler, Marianne
name: Hirons, Alex
name: Kneale, Catherine
name: Barrett, James H.
name: Star, Bastiaan
Publisher: name: Zenodo
Year: 2024
Subjects: cod-trade
historical fisheries
aDNA
Stable isotopes
long-distance fish trade

description: Marine resources have been important for the survival and economic development of coastal human communities across northern Europe for millennia. Knowledge of the origin of such historic resources can provide key insights into fishing practices and the spatial extent of trade networks. Here, we combine ancient DNA and stable isotopes (δ13C, δ15N, non-exchangeable δ2H, and δ34S) to investigate the geographical origin of archaeological cod remains in Oslo from the eleventh to seventeenth centuries CE. Our findings provide genetic evidence that Atlantic cod was obtained from different geographical populations, including a variety of distant-water populations like northern Norway and possibly Iceland. Evidence for such long-distance cod trade is already observed from the eleventh century, contrasting with archaeological and historical evidence from Britain and other areas of Continental Europe around the North and Baltic Seas, where such trade increased during the thirteenth to fourteenth centuries. The genomic assignments of specimens to different populations coincide with significantly different δ13C values between those same specimens, indicating that multiple Atlantic cod populations living in different environments were exploited. This research provides novel information about the exploitation timeline of specific Atlantic cod stocks and highlights the utility of combining ancient DNA methods and stable isotope analysis to describe the development of medieval and post-medieval marine fisheries.
description: Funding provided by: The Research Council of NorwayROR ID: https://ror.org/00epmv149Award Number: NFR300829
Funding provided by: European UnionROR ID: https://ror.org/019w4f821Award Number: Horizon 2020 Research
Funding provided by: Marie CurieROR ID: https://ror.org/02aqv1x10Award Number: 813383
Funding provided by: 4-OCEANSCrossref Funder Registry ID: Award Number:
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
Creators: name: Ohlsen, Knut
name: Lalk, Michael
name: Mardia Telep El-Sayed
name: Zoraghi, Roya
name: Reiner, Neil
name: Suzen, Sibel
name: Altanlar, Nurten
name: Hilgeroth, Andreas
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Meta Science
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: Novel bisindolyl-cycloalkane indoles resulted from the reaction of aliphatic dialdehydes and indole. As bisindolyl-natural alkaloid compounds have recently been reported as inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase (PK), we tested our novel compounds as MRSA PK inhibitors and now report first inhibiting activities. We discuss structure–activity relationships of structurally varied compounds. Activity influencing substituents have been characterized and relations to antibacterial activities of the most active compounds have been proved.
Estimated electric conductivities of thermal plasma for air-fuel combustion and oxy-fuel combustion with potassium or cesium seeding
Creators: name: Marzouk, Osama A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Numerical Analysis (math.NA)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: J.2; I.6.3
subject: 76W05, 76-10

description: A complete model for estimating the electric conductivity of combustion product gases, with added cesium (Cs) or potassium (K) vapor for ionization, is presented. Neutral carrier gases serve as the bulk fluid that carries the seed material, as well as the electrons generated by the partial thermal (equilibrium) ionization of the seed alkali metal. The model accounts for electron-neutral scattering, as well as electron-ion and electron-electron scattering. The model is tested through comparison with published data. The model is aimed at being utilized for the plasma within magnetohydrodynamic (MHD) channels, where direct power extraction from passing electrically conducting plasma gas enables electric power generation. The thermal ionization model is then used to estimate the electric conductivity of seeded combustion gases under complete combustion of three selected fuels, namely: hydrogen (H2), methane (CH4), and carbon (C). For each of these three fuels, two options for the oxidizer were applied, namely: air (21 % molecular oxygen, 79 % molecular nitrogen by mole), and pure oxygen (oxy-combustion). Two types of seeds (with 1 % mole fraction, based on the composition before ionization) were also applied for each of the six combinations of (fuel-oxidizer), leading to a total of 12 different MHD plasma cases. For each of these cases, the electric conductivity was computed for a range of temperatures from 2000 K to 3000 K. The smallest estimated electric conductivity was 0.35 S/m for oxy-hydrogen combustion at 2000 K, with potassium seeding. The largest estimated electric conductivity was 180.30 S/m for oxy-carbon combustion at 3000 K, with cesium seeding. At 2000 K, replacing potassium with cesium causes a gain in the electric conductivity by a multiplicative gain factor of about 3.6 regardless of the fuel and oxidizer. This gain factor declines to between 1.77 and 2.07 at 3000 K.
description: 28 pages, 16 figures, 14 tables
The acute respiratory exposure by intratracheal instillation of Sprague–Dawley rats with diesel particulate matter induces retinal thickening
Creators: name: Sungjin Kim
name: Hyelim Park
name: Hyewon Park
name: Boyoung Joung
name: Eunkyung Kim
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: Cell Biology
subject: Medicine
subject: Engineering

description: Context: Adverse health effects of ambient particulate matter (PM) have been demonstrated in humans, mostly in terms of respiratory and cardiovascular events. However, whether ambient particle could affect the eyes had not been fully revealed.Objective: This study investigated the effect of acute respiratory exposure to PM on eyes.Methods: Diesel exhaust product (DEP) of 200 mg/l was given endotracheally in Sprague–Dawley rats for 1 h (n = 12) and compared to normal control (n = 4). We enucleated eyes and histologically evaluated. Immunohistochemical stains for CD34 (Dako, Glostrup, Denmark, 1:50) and Ki-67 (DakoCytomation, Glostrup, Denmark, 1:150) were performed to evaluate new vessel formation and proliferation activity.Results: After endotracheal DEP exposure, the thickness of retina was significantly increased to 258 ± 96 μm in DEP group, while that of control was 113 ± 9 μm (p = 0.025). Among the retinal structure, inner plexiform, inner and outer nuclear and rod/cone cell layers were significantly thickened (p = 0.00, 0.017, 0.004, 0.001, respectively). The outer plexiform layer of DEP group showed a tendency of thickening, but statistically insignificant. The afferent fiber and ganglion cell layer showed no thickness difference between two groups, but prominent capillaries with congestion were noted in DEP group. Neither neovascularization nor increased proliferation was demonstrated on CD34 and Ki-67 immunohistochemical staining in DEP group.Conclusion: This study shows that the acute respiratory exposure of ambient PM increased retinal thickness, especially inner plexiform, inner and outer nuclear and rod/cone cell layers. We thought that increase of retinal thickness in DEP group resulted in hypoxia-induced edema.
title: Основы теории принятия решений
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии рассмотрены основные понятия, подходы и результаты теории принятия решений. Дано введение в линейное и целочисленное программирование. Рассмотрены, описаны задачи оптимизации на графах. В теории экспертных оценок, выраженных бинарными отношениями, применены расстояние Кемени и медиана Кемени. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, преподавателей и специалистов, заинтересованных в применении современных методов теории принятия решений в технике, экономике, управлении, медицине, социологии и иных областях, а также для разработчиков таких методов и соответствующего программного обеспечения.
Interconnectedness with the natural world : a journey of moments and interactions
Creators: name: Peters, Carly Grace
Publisher: name: University of Tasmania
Year: 2024

description: Interconnectedness with the Natural World: a journey of moments and interactions explores and responds to the human individual's relationship with the organic environment. This project examines those moments when the individual may have a sense of connection, of interconnection to the organic environment. This study explores times such as when a very human interaction with the natural environment occurs - running barefoot in the grass - and the sudden awareness of and awakening to their surrounds that transpires. The idea of the moment is integral to the research, and a creature that I have come to see as being a hybrid of both time and place. This moment that contains the individual and their experience of interconnection with their surrounds is one that has propelled the further study of the very subjective nature of human interactions with their surrounds. I examine the way in which time and place play their roles in these very personal and organic moments between the two protagonists. I explore and delve into the way these moments of interconnectedness with the organic environment contain so very much - the concept of time and place and experience and Self, but also the very physicality of these elements. It is this somewhat intangible and undefinable nature of time, place and experience that relates directly to that open-endedness of the moment, and reinforces the concept. In a similar way, the very subjective manner of the human experience of these elements is enveloped and encapsulated by the equally subjective nature of this moment of interconnectedness. My creative responses to these ideas take the form of both a visual and sound-based installation. Both components of the work remain very organic in response to the organic subject of my research. I focus heavily on utilising organic, recycled materials and sounds taken directly from the environment to respond to and reflect on these explorations of the subjective nature of the moment of interaction with the surrounding organic world. I have created a space where I endeavour to show the work in such a way that it invites the viewer to experience it, correlating directly to the idea of the subjective experience of the individual. The greatest importance of this research, visual, sound and theoretical has been to gain a greater understanding of and arrive at a realisation of the very organic yet intangible nature of this moment of interaction between the individual and the organic environment. I have endeavoured to arrive at a deeper and more comprehensive understanding of the moment of experience that occurs between the two, the role of time, place and experience, and the sense of interconnectedness that arises.
title: Прикладной статистический анализ
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебник посвящен основным методам современной прикладной статистики. В нем рассмотрены вероятностно-статистическая база и основные проблемы прикладной статистики — описание данных, оценивание, проверка гипотез. Описываются методы статистического анализа числовых величин, многомерного статистического анализа, временных рядов, статистики нечисловых и интервальных данных. Обсуждается методология прикладной статистики, ее современное состояние и перспективы развития. Изложение соответствует рекомендациям Российской академии статистических методов. Каждая глава учебника — это введение в большую область прикладной статистики. Приведенные литературные ссылки помогут выйти на передний край теоретических и прикладных работ, познакомиться с доказательствами теорем, помещенных в учебник. Подготовлен с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебник предназначен для студентов направлений подготовки 02.03.01 «Математика и компьютерные науки» (дисциплина «Теория вероятностей и математическая статистика»), 09.03.03 «Прикладная информатика» (дисциплина «Прикладной статистический анализ»), 27.03.05 «Инноватика» (дисциплина «Эконометрика»), 38.03.01 «Экономика» (дисциплины «Основы теории вероятностей и математической статистики», «Статистика»), 38.03.02 «Менеджмент» (дисциплина «Прикладная статистика»), а также будет полезен для студентов и преподавателей вузов, научных и практических работников, имеющих отношение к анализу данных.
title: Проблемы управления экологической безопасностью
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии рассмотрены основные экологические проблемы современного мира, понятия экологического риска и экологической безопасности, правовые основы обеспечения экологической безопасности в России, вопросы установления и контроля (в том числе статистического) экологических требований. Выработаны экспертные методы принятия решений в экологии (в том числе экологические экспертизы) и механизмы управления экологической безопасностью (в том числе основные идеи экологического страхования). Также были изучены социально-экологические аспекты управления и современные проблемы управления экологической безопасностью. Исходя из принципа «Образование через науку» на основе двадцатилетнего опыта научных исследований и преподавания подготовлена эта книга, которую в равной степени можно считать и учебным пособием, и научной монографией. Она будет полезна научным работникам, ведущим теоретические и прикладные исследования в области управления экологической безопасностью; экологам, инженерам, управленцам, экономистам, занимающимся практическими задачами природоохранной деятельности; преподавателям экологических дисциплин; студентам и аспирантам, изучающим проблемы экологической безопасности; специалистам, повышающим квалификацию в области экологии.
title: Frog Story
title: Histoire de la grenouille
titleType: AlternativeTitle
Creators: name: Seifen, Karl
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Shan
subject: shn

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Elicitation du l'histoire Frog Story. Stimulus: Mercer Mayer (1989) Frog, where are you?
Abstraction in Computer Music Software Systems
Creators: name: Geiger, Gunter
Publisher: name: Zenodo
Year: 2005

description: In its almost 50 years of existence the field of computer music has brought us dozens of software systems, and new ones are still being added. This is a sign of the fields vitality and of constant interest in improving the tools that are used in order to make music on computers. This work is primarily an overview of existing systems, from a conceptual point of view, in an attempt to extract the essence of computer music systems and to pinpoint the software models that work best in the computer music domain. The criteria are °exibility, speed and - drawn from human computer interaction - intuitiveness of the programming model. Secondarily it is a review of my research work in this direction and finally an attempt to reassemble the best ideas into a consistent, fast, flexible and easy to use interactive computer music system that foments experimentation and creativity. The domain of this work is very broad and it can't give all the answers, but it hopefully manage to ask the right questions.
title: Теория принятия решений
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебнике представлена структура современной теории принятия решений. Рассмотрены технология и процедуры разработки и принятия управленческих решений, описаны вероятностно-статистические, интервальные, нечеткие, а также связанные со шкалами измерения неопределенности в теории принятия решений. Приведены методы принятия решений, в том числе оптимизационные, вероятностно-статистические, экспертные. Отдельно рассмотрено моделирование как метод теории принятия решений и проведен анализ ряда конкретных моделей. Обсуждаются методы принятия решений как традиционные, так и современные, даются примеры их применения для решения практических задач. Подготовлен с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебник предназначен для студентов и преподавателей вузов, слушателей институтов повышения квалификации, структур второго образования и программ МВА («Мастер делового администрирования»), менеджеров, экономистов, инженеров.
Cytotoxic effects of octenidine mouth rinse on human fibroblasts and epithelial cells – an in vitro study
Creators: name: J. Schmidt
name: V. Zyba
name: K. Jung
name: S. Rinke
name: R. Haak
name: R. F. Mausberg
name: D. Ziebolz
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Objectives: This study compared the cytotoxicity of a new octenidine mouth rinse (MR) against gingival fibroblasts and epithelial cells with different established MRs. Methods: The following MRs were used: Octenidol (OCT), Chlorhexidine 0.2% (CHX), Listerine (LIS), Meridol (MER), Betaisodona (BET); and control (medium only). Human primary gingiva fibroblasts and human primary nasal epithelial cells were cultivated in cell-specific media (2 × 105 cells/ml) and treated with MR for 1, 5, and 15 min. Each test was performed 12 times. Metabolism activity was measured using a cytotoxicity assay. A cellometer analyzed cell viability, cell number, and cell diameter. The data were analyzed by two-way analysis of variance with subsequent Dunnett’s test and additional t-tests. Results: The cytotoxic effects of all MRs on fibroblasts and epithelial cells compared to the control depended on the contact time (p p > 0.005). Cell numbers of both cell types at all contact times revealed that OCT showed a less negative effect (p > 0.005), especially for epithelial cells compared to CHX after 15 min (p p > 0.005), but MER showed less influence than OCT in epithelial cells (p Conclusions: OCT is a potential alternative to CHX regarding cytotoxicity because of its lower cell-toxic effect against fibroblasts and epithelial cells.
title: Устойчивые экономико-математические методы и модели
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В работе предложена общая схема устойчивости, позволяющая разрабатывать и развивать экономико-математические методы и модели на основе единого методологического подхода. Охарактеризованы модели с дисконтированием, обосновано применение асимптотически оптимальных планов. Разработаны непараметрические методы оценки характеристик, прогнозирования, проверки однородности выборок, статистические методы для анализа результатов наблюдений, лежащих в пространствах произвольной природы, а также устойчивые экономико-математические методы и модели технологий экспертных оценок, управления инновациями и инвестициями, качеством продукции, запасами, рисками. Найдены условия применимости критериев Стьюдента и Вилкоксона. Развиты методы моделирования и анализа конкретных типов объектов нечисловой природы. Издание предназначено для исследователей, преподавателей, студентов, практических работников, а также для всех, кто применяет математику в экономике и менеджменте.
Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast
Creators: name: Kelly, Thomas J.
name: A. John Callegari
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: ABSTRACTDNA damage tolerance (DDT) mechanisms allow cells to synthesize a new DNA strand when the template is damaged. Many mutations resulting from DNA damage in eukaryotes are generated during DDT when cells use the mutagenic translesion polymerases, Rev1 and Polζ, rather than mechanisms with higher fidelity. The coordination among DDT mechanisms is not well understood. We used live-cell imaging to study the function of DDT mechanisms throughout the cell cycle of the fission yeast Schizosaccharomyces pombe. We report that checkpoint-dependent mitotic delay provides a cellular mechanism to ensure the completion of high fidelity DDT, largely by homology-directed repair (HDR). DDT by mutagenic polymerases is suppressed during the checkpoint delay by a mechanism dependent on Rad51 recombinase. When cells pass the G2/M checkpoint and can no longer delay mitosis, they completely lose the capacity for HDR and simultaneously exhibit a requirement for Rev1 and Polζ. Thus, DDT is coordinated with the checkpoint response so that the activity of mutagenic polymerases is confined to a vulnerable period of the cell cycle when checkpoint delay and HDR are not possible.
title: Экспертные оценки
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии рассмотрены вопросы теории и практики экспертных оценок, в том числе связанные с типовыми стадиями экспертного опроса, методами подбора экспертов, разработкой регламентов проведения сбора и анализа экспертных мнений. Представлены основные идеи современной теории измерений, метода согласования кластеризованных ранжировок и ряда других математических методов анализа экспертных оценок. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Предназначено для студентов, преподавателей и специалистов, заинтересованных в применении современных методов экспертных оценок в технике, экономике, управлении, медицине, социологии и иных областях, а также для разработчиков таких методов и соответствующего программного обеспечения. Представляет интерес также для исследователей и преподавателей в области искусственного интеллекта, прикладной и математической статистики, сбора и анализа экспертных данных, методов оптимизации, математического и организационно-экономического моделирования.