cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Results of a phase I/IIa trial of SV-BR-1-GM inoculation with low-dose cyclophosphamide and interferon alpha (Bria-IMT) in metastatic breast cancer
Creators: name: Wiseman, Charles L.
name: Holmes, Jarrod P.
name: Calfa, Carmen
name: Dakhil, Shaker R.
name: Bhattacharya, Saveri
name: Peoples, George E.
name: Lacher, Markus D.
name: Lopez-Lago, Miguel
name: Kharazi, Alex
name: Del Priore, Giuseppe
name: Chang, Mingjin
name: Adams, Daniel L.
name: Williams, William V.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: This Phase I/IIa open-label, single-arm clinical trial addressing advanced, refractory, metastatic breast cancer was conducted at six medical centers in the United States. We repeated inoculations with irradiated SV-BR-1-GM, a breast cancer cell line with antigen-presenting activity engineered to release granulocyte-macrophage colony-stimulating factor (GM-CSF), with pre-dose low-dose cyclophosphamide and post-dose local interferon alpha. Twenty-six patients were enrolled; 23 (88.5%) were inoculated, receiving a total of 79 inoculations. There were six Grade 4 and one Grade 5 adverse events noted (judged unrelated to SV-BR-1-GM). Disease control (stable disease [SD]) occurred in 8 of 16 evaluable patients; 4 showed objective regression of metastases, including 1 patient with near-complete regressions in 20 of 20 pulmonary lesions. All patients with regressions had human leukocyte antigen (HLA) matches with SV-BR-1-GM; non-responders were equally divided between matching and nonmatching (p = .01, Chi-squared), and having ≥2 HLA matches with SV-BR-1-GM (n = 6) correlated with clinical benefit. Delayed-type hypersensitivity (DTH) testing to candida antigen and SV-BR-1-GM generated positive responses (≥5 mm) in 11 (42.3%) and 13 (50%) patients, respectively. Quantifying peripheral circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAMLs) showed that a drop in CAMLs was significantly correlated with an improvement in progression-free survival (PFS; 4.1 months vs. 1.8 months, p = .0058). Eight of 10 patients significantly upregulated programmed cell death ligand 1 (PD-L1) on CTCs/CAMLs with treatment (p = .0012). These observations support the safety of the Bria-IMT regimen, demonstrate clinical regressions, imply a role for HLA matching, and identify a possible value for monitoring CAMLs in peripheral blood.
Additional file 4 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 4: Figure S2. Characterization of vessel density in TME. A GO analysis for significantly upregulated genes-related pathways in KL tumors compared to KP. B Representative immunofluorescent staining and quantification of CD31 in KL and KP tumors. Scale bars, 2 mm. Merge scale bars, 200 μm. Magnified scale bars, 100 μm. C Representative immunofluorescent staining and quantification of CD31 in KL tumors treated with FAK inhibitor at different time points (Day 3, 7,14). red, CD31 staining; blue, DAPI staining. Scale bars, 100 μm. D Representative IHC staining and quantification of HIF-1α in KL tumors treated with FAK inhibitor at different time points (Day 3, 7,14). Scale bar, 200um. Unpaired Student’s t-test was performed and results in each group were presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and nsp-values with no statistical difference.
“Going vaccine hunting”: Multilevel influences on COVID-19 vaccination among racialized sexual and gender minority adults—a qualitative study
Creators: name: Newman, Peter A.
name: Dinh, Duy Anh
name: Massaquoi, Notisha
name: Williams, Charmaine C.
name: Lacombe-Duncan, Ashley
name: Tepjan, Suchon
name: Nyoni, Thabani
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: High levels of COVID-19 vaccine hesitancy have been reported among Black and Latinx populations, with lower vaccination coverage among racialized versus White sexual and gender minorities. We examined multilevel contexts that influence COVID-19 vaccine uptake, barriers to vaccination, and vaccine hesitancy among predominantly racialized sexual and gender minority individuals. Semi-structured online interviews explored perspectives and experiences around COVID-19 vaccination. Interviews were recorded, transcribed, uploaded into ATLAS.ti, and reviewed using thematic analysis. Among 40 participants (mean age, 29.0 years [SD, 9.6]), all identified as sexual and/or gender minority, 82.5% of whom were racialized. COVID-19 vaccination experiences were dominated by structural barriers: systemic racism, transphobia and homophobia in healthcare and government/public health institutions; limited availability of vaccination/appointments in vulnerable neighborhoods; absence of culturally-tailored and multi-language information; lack of digital/internet access; and prohibitive indirect costs of vaccination. Vaccine hesitancy reflected in uncertainties about a novel vaccine amid conflicting information and institutional mistrust was integrally linked to structural factors. Findings suggest that the uncritical application of “vaccine hesitancy” to unilaterally explain undervaccination among marginalized populations risks conflating structural and institutional barriers with individual-level psychological factors, in effect placing the onus on those most disenfranchised to overcome societal and institutional processes of marginalization. Rather, disaggregating structural determinants of vaccination availability, access, and institutional stigma and mistrust from individual attitudes and decision-making that reflect vaccine hesitancy, may support 1) evidence-informed interventions to mitigate structural barriers in access to vaccination, and 2) culturally-informed approaches to address decisional ambivalence in the context of structural homophobia, transphobia, and racism.
Additional file 2 of A reliability analysis: human trafficking curriculum assessment tool (HT-CAT) for health care provider human trafficking trainings
Creators: name: Stoklosa, Hanni
name: Wang, Xichen
name: Meng, Boci
name: Rydberg, Jason
name: Adewusi, Adebimpe
name: Barney, Madison Murphy
name: Glassman, Kendra
name: Napolitano, Kara
name: Wald, Claudia
name: Bachrach, Lela
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 2
Assessing NASA's Earth Science Metadata Quality: ARC and pyQuARC
Creators: name: Kirkland, Sheyenne
name: Bayat, Farnaz
name: Koontz, Emma
name: Wood, Jenny
Publisher: name: Zenodo
Year: 2024
Subjects: Metadata
Earth Science
Curation
Open Science
Metadata Quality

description: As of writing this description (November 2024), NASA's Earthdata Search holds nearly 10,000 data collections, consisting of several decades-worth of Earth Observation (EO) information. In order for users to find the data they need, it is important to ensure that the metadata is correct and as expansive as possible. Correct and complete metadata is also important because incomplete or inaccurate metadata could discourage users from accessing or using the associated data. To help ensure that EO metadata meets certain standards (which also ultimately furthers open science efforts), NASA established the Analysis and Review of CMR (ARC) project. ARC and NASA ESDIS (Earth Observing System Data and Information System) collaborated to create a metadata framework, which established a set of requirements and best-practices for EO metadata. ARC conducts manual assessments of collections and granules within Earthdata Search using the framework, and has also created an open-source tool called pyQuARC to help automate ARC's process as much as possible. This brief presentation gives a glimpse into ARC and pyQuARC's process, and also shows the positive impact of both efforts so far.
Additional file 5 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5: Figure S3. The intrinsic interactions between LKB1 and FAK pathway in tumor cells. A Western blot analysis for FAK signaling upon overexpressing or interfering with LKB1 in three cell lines. B Cell viability tests for KL cell lines treated with FAK inhibitors for three time points. C Representative flow cytometry images and cell apoptosis analysis for KL tumor cells treated with different doses of FAK inhibitors and different time points. One-way analysis of variance (ANOVA) was performed. ns represents p-values with no statistical difference.
Nonuniqueness of generalised weak solutions to the primitive and Prandtl equations
Creators: name: Boutros, Daniel W.
name: Markfelder, Simon
name: Titi, Edriss S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 76B03 (primary), 35Q35, 35D30, 35A01, 35A02, 76D03, 42B35, 42B37 (secondary)

description: We develop a convex integration scheme for constructing nonunique weak solutions to the hydrostatic Euler equations (also known as the inviscid primitive equations of oceanic and atmospheric dynamics) in both two and three dimensions. We also develop such a scheme for the construction of nonunique weak solutions to the three-dimensional viscous primitive equations, as well as the two-dimensional Prandtl equations.
 While in [D.W. Boutros, S. Markfelder and E.S. Titi, Calc. Var. Partial Differential Equations, 62 (2023), 219] the classical notion of weak solution to the hydrostatic Euler equations was generalised, we introduce here a further generalisation. For such generalised weak solutions we show the existence and nonuniqueness for a large class of initial data. Moreover, we construct infinitely many examples of generalised weak solutions which do not conserve energy. The barotropic and baroclinic modes of solutions to the hydrostatic Euler equations (which are the average and the fluctuation of the horizontal velocity in the $z$-coordinate, respectively) that are constructed have different regularities.
description: 78 pages
Immunogenicity of COVID-19 vaccines in patients with cirrhosis: A meta-analysis
Creators: name: Ouyang, Lichen
name: Lei, Gang
name: Gong, Yeli
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: The immunogenicity of COVID-19 vaccines in patients with liver cirrhosis remains largely unknown. The purpose of this meta-analysis was to investigate the immunogenicity of COVID-19 vaccines in patients with cirrhosis and compare the humoral and cellular immune responses following complete COVID-19 vaccination between cirrhosis patients and healthy controls. A systematic literature search was conducted in PubMed, EMBASE, and Web of Science from 1 January 2020 to 22 August 2023. Sixteen studies with 2127 cirrhosis patients were included. The pooled seroconversion rate in patients with cirrhosis following complete COVID-19 vaccination was 92.4% (95% CI, 86.2%–96%, I2 = 90%) with significant between-study heterogeneity. Moreover, COVID-19 vaccination elicited a higher humoral immune response in patients of compensated cirrhosis as compared with decompensated cirrhosis (RR = 1.069, 95% CI, 1.011–1.131, I2 = 17%, p = .019). Additionally, 10 studies were included for comparison analysis of seroconversion rate between cirrhosis patients and healthy controls. The results showed that the seroconversion rate in patients with cirrhosis was slightly lower compared with healthy controls (RR = 0.972, 95% CI, 0.955–0.989, I2 = 66%, p = .001). Meanwhile, the pooled RR of cellular immune response rate for cirrhosis patients vs. healthy controls was 0.678 (95% CI, 0.563–0.817, I2 = 0, p < .0001). Our meta-analysis demonstrated that COVID-19 vaccination elicited diminished humoral and cellular immune responses in patients of cirrhosis. Patients with cirrhosis particularly decompensated cirrhosis who have completed full-doses of COVID-19 vaccination should receive continuous attention and preemptive measures.
sj-pdf-1-css-10.1177_2470547020979780 - Supplemental material for The Relative Effects of Prazosin on Individual PTSD Symptoms: Evidence for Pathophysiologically-Related Clustering
Creators: name: Hendrickson, Rebecca C.
name: Millard, Steven P.
name: Pagulayan, Kathleen F.
name: Peskind, Elaine R.
name: Raskind, Murray A.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-css-10.1177_2470547020979780 for The Relative Effects of Prazosin on Individual PTSD Symptoms: Evidence for Pathophysiologically-Related Clustering by Rebecca C. Hendrickson, Steven P. Millard, Kathleen F. Pagulayan, Elaine R. Peskind and Murray A. Raskind in Chronic Stress
Additional file 6 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 6: Figure S4. FAK inhibitor enhanced proliferation of immune cells and elevated PD-L1 expression on tumor cell. A Representative flow cytometry images at Day 14 and histogram showed the percentage of intratumoral Ki67 + of CD45 + cells at indicated time points. B Representative flow cytometry images at Day 14 and histogram showed the percentage of intratumoral CD45−PD-L1+ of total viable cells at indicated time points. Unpaired Student’s t-test was performed and results in each group were presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and nsp-values with no statistical difference.
A novel orf virus vector-based COVID-19 booster vaccine shows cross-neutralizing activity in the absence of anti-vector neutralizing immunity
Creators: name: Klinkhardt, Ute
name: Schunk, Mirjam
name: Ervin, John
name: Schindler, Christoph
name: Sugimoto, Danny
name: Rankin, Bruce
name: Amann, Ralf
name: Monti, Martina
name: Kutschenko, Anna
name: Schumacher, Carsten
name: Huber, Kristina
name: Zeder, Andreas
name: Heikkila, Nelli
name: Didierlaurent, Arnaud M.
name: Schwarz, Sylvia E.
name: Derouazi, Madiha
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of protection. Prime-2-CoV_Beta is an orf virus (ORFV) based multi-antigen COVID-19 vaccine that co-expresses Spike (S) and Nucleocapsid (N) antigens. The safety and immunogenicity of Prime-2-CoV_Beta is investigated in a phase 1 first-in-human (FIH) dose-finding trial (ORFEUS study, ClinicalTrials.gov: NCT05367843). Participants of two age groups (18–55 and 65–85 years) who previously completed at least two doses of mRNA vaccines were enrolled and sequentially assigned to different dose groups to receive one intramuscular dose of 3 × 105, 3 × 106, 1.5 × 107, or 3 × 107 plaque-forming units (PFU) of Prime-2-CoV_Beta on day 1 and a second dose on day 29. Here, we report safety and immunogenicity data collected up to 6 months after the first study vaccination. Prime-2-CoV_Beta is safe and well tolerated and elicits immune responses at higher dose levels in participants aged 18–55. A single dose of 3 × 107 PFU boosted binding and cross-neutralizing antibody responses that are maintained through 6 months after the first booster vaccination. Polyfunctional S-specific CD4+ and CD8+ T cell responses are observed after vaccination. No pre-existing or vaccine-induced neutralizing anti-vector antibodies are detected. Our findings highlight the potential of the ORFV vector as a safe platform for future vaccine design, which provides the ability to deliver multiple antigens and allows for repeat immunization.
sj-docx-1-mdm-10.1177_0272989X21994035 – Supplemental material for The Value of Triage during Periods of Intense COVID-19 Demand: Simulation Modeling Study
Creators: name: Wood, Richard M.
name: Pratt, Adrian C.
name: Kenward, Charlie
name: McWilliams, Christopher J.
name: Booton, Ross D.
name: Thomas, Matthew J.
name: Bourdeaux, Christopher P.
name: Vasilakis, Christos
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-mdm-10.1177_0272989X21994035 for The Value of Triage during Periods of Intense COVID-19 Demand: Simulation Modeling Study by Richard M. Wood, Adrian C. Pratt, Charlie Kenward, Christopher J. McWilliams, Ross D. Booton, Matthew J. Thomas, Christopher P. Bourdeaux and Christos Vasilakis in Medical Decision Making
E05645: The Miracles of Saint Thekla recounts how *Thekla (follower of the Apostle Paul, S00092) delivered the city of Selinous (Asia Minor) from attacks of the enemies by bidding the inhabitants erect a church dedicated to her at the top of the path leading to the city. Written in Greek at Seleucia ad Calycadnum (southern Asia Minor) in the 470s.
Creators: name: Julia
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Miracles of Saint Thekla, 27

Summary:

Selinous was a small coastal city [in Isauria] which was once prosperous and important but then attracted enemies. Even though its location over the sea, with an overhanging cliff, protected it, one day it was delivered to its enemies through the action of a savage demon. For once a goat-herd went to pasture his flock along the summit of the crest around the city. One of the goats separated itself from the rest and found a hidden narrow path by which it descended and arrived at the plain, while the goat-herd and the other goats descended step by step down the slope. From this descent the previously unknown path was revealed to everyone at once, even to neighbouring enemies. Thus the city was captured in this way, and thereafter the inhabitants lived in fear that it would be taken again and again. But the martyr Thekla removed this great fear by visiting one of the local men and instructing him to erect a church dedicated to her at the very top, at the beginning of the path leading downward. The inhabitants did it and built the church as a fortification against enemies. The latter made many unsuccessful attempts, but never managed to capture the city again.

Text: Dagron 1978. Summary: J. Doroszewska.
sj-pdf-2-ejo-10.1177_1120672121992949 – Supplemental material for Ophthalmology-focused publications and findings on COVID-19: A systematic review
Creators: name: Jin, Ya-Ping
name: Trope, Graham E
name: El-Defrawy, Sherif
name: Liu, Elin Y
name: Buys, Yvonne M
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-2-ejo-10.1177_1120672121992949 for Ophthalmology-focused publications and findings on COVID-19: A systematic review by Ya-Ping Jin, Graham E Trope, Sherif El-Defrawy, Elin Y Liu and Yvonne M Buys in European Journal of Ophthalmology
Additional file 7 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 7: Figure S5. FAK inhibitor mediated positive immune-response in spleen in KL tumor models. A Representative flow cytometry images at Day 14 and histogram showed the percentage of splenic CD3+ of CD45+ cells at different time points. Ratio of splenic, B CD19+ cells, C CD3−NK1.1+ cells to CD45+cells, D CD4+Foxp3+ to CD3+cells at indicated time points. E Gating strategy for subtypes of CD4+ or CD8+T cells in spleen (left) and histogram showed the percentage of splenic CD8+T cells, naïve CD8+T cells (CD44lowCD62Lhigh), effector memory CD8+T cells (CD44highCD62Llow), central memory CD8+T cells (CD44highCD62Lhigh), CD4+T cells, naïve CD4+T cells (CD44lowCD62Lhigh), effector memory CD4+T cells (CD44highCD62Llow), central memory CD4+T cells (CD44highCD62Lhigh). F Gating strategy for DCs and histogram showed the percentage of splenic CD11c+MHC-IImed DCs and CD11c+MHC-IIhigh DCs of CD45+ cells at different time points. G Gating strategy for MDSC subtypes and histogram showed the percentage of splenic M-MDSC (CD11b+Ly6ChighLy6Glow) and PMN-MDSC (CD11b + Ly6ClowLy6Ghigh) at different time points. H Representative flow cytometry images at Day 7 and histogram showed the percentage of splenic macrophage (CD11b+F4/80+) of CD45 + cells at different time points. Unpaired Student’s t-test was performed and results in each group were presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and nsp-values with no statistical difference.
sj-pdf-1-wmr-10.1177_0734242X20988783 – Supplemental material for Feasibility study of the unit pricing system for household wastes sorting in the context of China
Creators: name: Li, Wenhua
name: Wang, Juntao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Public Health and Health Services not elsewhere classified
Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-wmr-10.1177_0734242X20988783 for Feasibility study of the unit pricing system for household wastes sorting in the context of China by Wenhua Li and Juntao Wang in Waste Management & Research
sj-pdf-1-jhs-10.1177_1753193421991062 - Supplemental material for Measurement of finger joint motion after flexor tendon repair: smartphone photography compared with traditional goniometry
Creators: name: Chen, Jing
name: Xian Zhang, Ai
name: Jia Qian, Si
name: Jing Wang, Yu
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery

description: Supplemental material, sj-pdf-1-jhs-10.1177_1753193421991062 for Measurement of finger joint motion after flexor tendon repair: smartphone photography compared with traditional goniometry by Jing Chen, Ai Xian Zhang, Si Jia Qian and Yu Jing Wang in Journal of Hand Surgery (European Volume)
Additional file 1 of Women’s wellbeing as an empty declaration? A qualitative exploration of challenges in accessing termination of pregnancy due to fetal anomaly in Germany
Creators: name: Nov-Klaiman, Tamar
name: Bowman-Smart, Hilary
name: Horn, Ruth
Publisher: name: figshare
Year: 2025
Subjects: subject: Law
subject: FOS: Law

description: Supplementary Material 1.
High burden of human papillomavirus infection among men in Guangzhou, South China: Implications for HPV vaccination strategies
Creators: name: Liu, Pan
name: Yang, Xiaohan
name: Zhao, Hongyu
name: Liang, Lihua
name: Chen, Minchai
name: Yin, Aihua
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The epidemiological and clinical aspects of Human Papillomavirus (HPV) infection in women have been extensively studied. However, there is a lack of information regarding HPV characteristics in males. In this study, we conducted a retrospective and observational study of 3737 consecutive male individuals attending outpatient clinics of Guangdong Women and Children Hospital from 2012 to 2023 in Guangzhou, South China, to determine the age- and genotype-specific prevalence of HPV in men. The results showed the overall prevalence of HPV among men was 42.15% (1575/3737), with variations ranging from 29.55% to 81.31% across distinct diagnostic populations. Low-risk HPV6 (15.47%), HPV11 (8.94%), and high-risk HPV52 (5.51%) were the most common types. The annual HPV prevalence decreased significantly (Z = −3.882, p < .001), ranging from 31.44% to 52.90%. 28.77% (1075/3737) of men manifested infection with a singular HPV type, predominantly identified as a low-risk type. The age-specific distribution of HPV infections revealed distinctive peaks in the < 25 y age group (47.60%, 208/437) and the 40–44 y age group (44.51%, 154/346). Notably, the positive rate of Chlamydia trachomatis was significantly higher among HPV-positive individuals in comparison to HPV-negatives (16.14% vs. 11.25%, p < .05). Our findings reveal a substantial prevalence of HPV infection among outpatient men in Guangzhou, South China. It is recommended to consider the inclusion of HPV vaccination for adolescent males in national immunization schedules, once an adequate supply of vaccines is accessible.
Additional file 8 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 8: Figure S6. Cytokines in KP, KL tumors and impact of FAK inhibitors on levels of cytokines in KL tumors. A Heatmap of RNA-seq showing cytokines-related genes statistically significantly (FDR < 0.05) differentially expressed in KL subcutaneous tumors. B Luminex liquid suspension chip evaluating indicated cytokines levels upon FAK inhibition at different time points (D3, D7). Unpaired Student’s t-test was performed and results in each group were presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ns represents p-values with no statistical difference.
Learning to solve Bayesian inverse problems: An amortized variational inference approach using Gaussian and Flow guides
Creators: name: Karumuri, Sharmila
name: Bilionis, Ilias
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Inverse problems, i.e., estimating parameters of physical models from experimental data, are ubiquitous in science and engineering. The Bayesian formulation is the gold standard because it alleviates ill-posedness issues and quantifies epistemic uncertainty. Since analytical posteriors are not typically available, one resorts to Markov chain Monte Carlo sampling or approximate variational inference. However, inference needs to be rerun from scratch for each new set of data. This drawback limits the applicability of the Bayesian formulation to real-time settings, e.g., health monitoring of engineered systems, and medical diagnosis. The objective of this paper is to develop a methodology that enables real-time inference by learning the Bayesian inverse map, i.e., the map from data to posteriors. Our approach is as follows. We parameterize the posterior distribution as a function of data. This work outlines two distinct approaches to do this. The first method involves parameterizing the posterior using an amortized full-rank Gaussian guide, implemented through neural networks. The second method utilizes a Conditional Normalizing Flow guide, employing conditional invertible neural networks for cases where the target posterior is arbitrarily complex. In both approaches, we learn the network parameters by amortized variational inference which involves maximizing the expectation of evidence lower bound over all possible datasets compatible with the model. We demonstrate our approach by solving a set of benchmark problems from science and engineering. Our results show that the posterior estimates of our approach are in agreement with the corresponding ground truth obtained by Markov chain Monte Carlo. Once trained, our approach provides the posterior distribution for a given observation just at the cost of a forward pass of the neural network.
The European Muon Collaboration effect from short-range correlated nucleons in a nucleon swelling model
Creators: name: Ma, Na-Na
name: Wang, Tao-Feng
name: Wang, Rong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The relation between the nuclear EMC effect and the nucleon-nucleon short-range correlation is a hot topic in high-energy nuclear physics, ever since a peculiar linear correlation between these two phenomena discovered. In this paper, the contribution to the nuclear EMC effect arising from the short-range correlated nucleons is examined in a nucleon-swelling model. We find that the structure modifications of the N-N SRC nucleons reproduce more or less the measured EMC ratios of light nuclei, while they are not enough to explain the measured EMC ratios of heavy nuclei. We speculate that the hypothesis of causal connection between SRC and the EMC effect is not exact, or the universality of the inner structure of SRC nucleon is violated noticeably from light to heavy nuclei, or there are other origins for the EMC effect.
description: 9 pages, 6 figures
sj-pdf-1-pul-10.1177_2045894021991446 - Supplemental material for Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers
Creators: name: Hythem Nawaytou
name: Fineman, Jeffrey R.
name: Moledina, Shahin
name: Dunbar Ivy
name: Abman, Steven H.
name: Cerro, Maria J. Del
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-pul-10.1177_2045894021991446 for Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers by Hythem Nawaytou, Jeffrey R. Fineman, Shahin Moledina, Dunbar Ivy, Steven H. Abman and Maria J. Del Cerro in Pulmonary Circulation
A rare case of Giant chorioangioma complicating pregnancy with fetal hydrops
Creators: name: Ghanchi, Alisha
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Foetal imaging
subject: Obstetric imaging
subject: MR
subject: PACS
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Fetus
subject: Obstetrics

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 32 years
description: Clinical History: A 32-year-old gravida3 para2 woman presented with complaints of dyspnea, pedal edema at  approx. 33weeks gestation. She had over distended abdomen. She wasn't a known case of diabetes or hypertension. Past pregnancies were uneventful resulting in normal v... Final Diagnosis: Placental chorioangioma with Hydrops fetalis.
A novel orf virus vector-based COVID-19 booster vaccine shows cross-neutralizing activity in the absence of anti-vector neutralizing immunity
Creators: name: Klinkardt, Ute
name: Schunk, Mirjam
name: Ervin, John
name: Schindler, Christoph
name: Sugimoto, Danny
name: Rankin, Bruce
name: Amann, Ralf
name: Monti, Martina
name: Kutschenko, Anna
name: Schumacher, Carsten
name: Huber, Kristina
name: Zeder, Andreas
name: Heikkila, Nelli
name: Didierlaurent, Arnaud M.
name: Schwarz, Sylvia E.
name: Derouazi, Madiha
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of protection. Prime-2-CoV_Beta is an orf virus (ORFV) based multi-antigen COVID-19 vaccine that co-expresses Spike (S) and Nucleocapsid (N) antigens. The safety and immunogenicity of Prime-2-CoV_Beta is investigated in a phase 1 first-in-human (FIH) dose-finding trial (ORFEUS study, ClinicalTrials.gov: NCT05367843). Participants of two age groups (18–55 and 65–85 years) who previously completed at least two doses of mRNA vaccines were enrolled and sequentially assigned to different dose groups to receive one intramuscular dose of 3 × 105, 3 × 106, 1.5 × 107, or 3 × 107 plaque-forming units (PFU) of Prime-2-CoV_Beta on day 1 and a second dose on day 29. Here, we report safety and immunogenicity data collected up to 6 months after the first study vaccination. Prime-2-CoV_Beta is safe and well tolerated and elicits immune responses at higher dose levels in participants aged 18–55. A single dose of 3 × 107 PFU boosted binding and cross-neutralizing antibody responses that are maintained through 6 months after the first booster vaccination. Polyfunctional S-specific CD4+ and CD8+ T cell responses are observed after vaccination. No pre-existing or vaccine-induced neutralizing anti-vector antibodies are detected. Our findings highlight the potential of the ORFV vector as a safe platform for future vaccine design, which provides the ability to deliver multiple antigens and allows for repeat immunization.
Additional file 10 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 10: Figure S8. Impact of combining FAK inhibitor and PD-1 blockade on TME in KL mouse model. Ratio of A CD3 + , B CD3 + CD19 + , C CD3-NK1.1 + , D CD8 + GZMB + to CD45 + cells, E CD4 + Foxp3 + to CD3 + cells. F Representative flow cytometry images and histogram showed the percentage of intratumoral DCs in each group. G Representative flow cytometry images and histogram showed the percentage of M-MDSC and PMN-MDSC in each group. H Representative flow cytometry images and histogram showed the percentage of macrophage, M1-like macrophage and M2-like macrophage in each group. Unpaired Student’s t-test was performed and results in each group were presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and nsp-values with no statistical difference.
Additional file 2 of Women’s wellbeing as an empty declaration? A qualitative exploration of challenges in accessing termination of pregnancy due to fetal anomaly in Germany
Creators: name: Nov-Klaiman, Tamar
name: Bowman-Smart, Hilary
name: Horn, Ruth
Publisher: name: figshare
Year: 2025
Subjects: subject: Law
subject: FOS: Law

description: Supplementary Material 2.
Additional file 9 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 9: Figure S7. Impact of combining FAK inhibitor and PD-1 blockade on vessel density in KL mouse model. Representative immunofluorescent staining and quantification of CD31 in KL tumors treated with different treatment schedule. red, CD31 staining; blue, DAPI staining. Scale bars, 100 μm. One-way analysis of variance (ANOVA) was performed. ns represents p-values with no statistical difference.
sj-docx-2-sph-10.1177_1941738121991782 – Supplemental material for Return to Play After Symptomatic Lumbar Disc Herniation in Elite Athletes: A Systematic Review and Meta-analysis of Operative Versus Nonoperative Treatment
Creators: name: Phelopater Sedrak
name: Shahbaz, Mustafa
name: Chetan Gohal
name: Madden, Kim
name: Aleem, Ilyas
name: Khan, Moin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine

description: Supplemental material, sj-docx-2-sph-10.1177_1941738121991782 for Return to Play After Symptomatic Lumbar Disc Herniation in Elite Athletes: A Systematic Review and Meta-analysis of Operative Versus Nonoperative Treatment by Phelopater Sedrak, Mustafa Shahbaz, Chetan Gohal, Kim Madden, Ilyas Aleem and Moin Khan in Sports Health: A Multidisciplinary Approach
Frequency Modulation Aggregation for Federated Learning
Creators: name: Martinez-Gost, Marc
name: Pérez-Neira, Ana
name: Lagunas, Miguel Ángel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Federated edge learning (FEEL) is a framework for training models in a distributed fashion using edge devices and a server that coordinates the learning process. In FEEL, edge devices periodically transmit model parameters to the server, which aggregates them to generate a global model. To reduce the burden of transmitting high-dimensional data by many edge devices, a broadband analog transmission scheme has been proposed. The devices transmit the parameters simultaneously using a linear analog modulation, which are aggregated by the superposition nature of the wireless medium. However, linear analog modulations incur in an excessive power consumption for edge devices and are not suitable for current digital wireless systems. To overcome this issue, in this paper we propose a digital frequency broadband aggregation. The scheme integrates a Multiple Frequency Shift Keying (MFSK) at the transmitters and a type-based multiple access (TBMA) at the receiver. Using concurrent transmission, the server can recover the type (i.e., a histogram) of the transmitted parameters and compute any aggregation function to generate a shared global model. We provide an extensive analysis of the communication scheme in an additive white Gaussian noise (AWGN) channel and compare it with linear analog modulations. Our experimental results show that the proposed scheme achieves no drop in performance up to $-10$ dB and outperforms the analog counterparts, while requiring 14 dB less in peak-to-average power ratio (PAPR) than linear analog modulations.
description: Paper accepted in 2023 IEEE Global Communications Conference
Visualizing immunotherapy for multiple myeloma worldwide from 2013 to 2023: A bibliometric analysis
Creators: name: Li, Jinqiao
name: Li, Xiaoxia
name: Fu, Yueyue
name: Meng, Hongbin
name: Xu, Dan
name: Hou, Wenyi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biotechnology
Cancer
Science Policy
Hematology

description: Multiple myeloma (MM) is a malignant, clonal proliferative disease of plasma cells that remains incurable. This paper aims to analyze the current research status and emerging trends in immunotherapy for MM through bibliometric methods, thereby providing valuable references and guidance for future research and clinical practice. This study presents a bibliometric analysis of 1,018 English-language publications related to MM immunotherapy, which were published in the Web of Science (WoS) Core Collection database from 2013 to 2023. VOSviewer and CiteSpace were employed to visualize the research hotspots and trends within the field of MM immunotherapy. The United States had the highest number of publications (n = 432, 42.44%), followed by China (n = 177, 17.39%). Harvard University was the institution with the most publications (n = 85), while Anderson KC (n = 27) was the most prolific researcher in the field. The highly cited literature mainly focuses on the treatment regimen based on daratumumab, the application of BCMA CAR-T therapy and the management of relapsed/refractory MM (RRMM), which represent the current research hotspots in this field. Burst detection highlights that bispecific antibodies and preclinical activity as key areas of interest. The cooperation among countries, institutions, and authors in this field should be strengthened. The treatment regimen utilizing daratumumab, the implementation of BCMA CAR-T therapy, and the management of RRMM represent significant research focal points in this field. Additionally, the development and application of bispecific antibodies have emerged as a frontier in recent years.
sj-pdf-1-hkj-10.1177_1024907921994426 – Supplemental material for Risk factors for venous thromboembolism after carbon monoxide poisoning: A nationwide population-based study
Creators: name: Yongil Cho
name: Lim, Tae Ho
name: Byuk Sung Ko
name: Hyunggoo Kang
name: Jaehoon Oh
name: Heekyung Lee
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-hkj-10.1177_1024907921994426 for Risk factors for venous thromboembolism after carbon monoxide poisoning: A nationwide population-based study by Yongil Cho, Tae Ho Lim, Byuk Sung Ko, Hyunggoo Kang, Jaehoon Oh and Heekyung Lee in Hong Kong Journal of Emergency Medicine
Implementation Of High Throughput Screening On Ips Cells
Creators: name: Kazemier, Bert
Publisher: name: Zenodo
Year: 2016
Subjects: iPS
iPSC
HTS
drug discovery

description: Pivot Park Screening Centre is a CRO specialized in high throughput screening and operates as the beating heart of the European Lead Factory (ELF). ELF is a pan-European platform for drug discovery, supported by IMI, which was launched 3 years ago to revitalize drug research in Europe. Comprising a collection of over 400,000 unique proprietary compounds and an experienced screening centre, the European Lead Factory will offer both researchers in academia and SMEs an unprecedented opportunity to advance medical research and develop new medicines.  The success of the European Lead Factory is witnessed by the completion of more than 40 screening campaigns and by the successful transfer of more than 20 Qualified Hit List reports to the target owners.   The over 40 HTS campaigns performed to date cover a wide range of target classes including more demanding cellular targets like ion channels and GPCR?s. Cellular HTS assays have been successfully miniaturized to 384- and 1536-well format in order to perform them in a cost-efficient manner. Induced pluripotent stem cells (iPSCs) belong to a growing list of stem cell populations that hold great potential for use in cell-based assay development and screening. iPSCs like cardiomyocytes and neuronal cells represent a reliable source of cellular material with robust assay performance and scalability which is essential to any HTS campaign . To demonstrate the impact of iPSCs in modern drug discovery we present examples of assay automation and miniaturization of cellular assays based on high content imaging using the Operetta and Ca-flux using the FLIPR instruments. Our examples show the opportunities and benefits that iPSc may provide in the search for new chemical starting points for drug discovery in the near future.
sj-pdf-1-isp-10.1177_0020764020988878 – Supplemental material for The psychological effects of COVID-19 spread in young Canadian adults
Creators: name: Praneet K. Gill
name: Du, Cynthia
name: Farihah Khan
name: Karimi, Nima
name: Kanav Sabharwal
name: Malvika Agarwal
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-isp-10.1177_0020764020988878 for The psychological effects of COVID-19 spread in young Canadian adults by Praneet K. Gill, Cynthia Du, Farihah Khan, Nima Karimi, Kanav Sabharwal and Malvika Agarwal in International Journal of Social Psychiatry
Additional file 1 of Change in economy of ultrasound probe motion among general medicine trainees
Creators: name: Salame, Gerard
name: Holden, Matthew
name: Lucas, Brian P.
name: Portillo, Albert
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Fig. S1. Image score. Fig. S2. Change in the difference between expert mean and trainees cohort Probe movements. Table S1. P values cutoff for statistical significance accounting for multiplicity using the Holhm–Bonferroni method.
Additional file 1 of Generation of an artificially attenuated fowl adenovirus 4 viral vector using the reverse genetics system based on full-length infectious clone
Creators: name: Tang, Zhihui
name: Feng, Dengfei
name: Fan, Wentao
name: Yan, Liping
name: Song, Suquan
Publisher: name: figshare
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 1. Detailed information about reference sequences.