cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epstein-Barr Virus Latent Membrane Protein 1 Regulates the Function of Interferon Regulatory Factor 7 by Inducing Its Sumoylation
Creators: name: Shackelford, J.
name: Pagano, J. S.
name: Bentz, G. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) induces multiple signal transduction pathways during latent EBV infection via its C-terminal activating region 1 (CTAR1), CTAR2, and the less-studied CTAR3. One mechanism by which LMP1 regulates cellular activation is through the induction of protein posttranslational modifications, including phosphorylation and ubiquitination. We recently documented that LMP1 induces a third major protein modification by physically interacting with the SUMO-conjugating enzyme Ubc9 through CTAR3 and inducing the sumoylation of cellular proteins in latently infected cells. We have now identified a specific target of LMP1-induced sumoylation, interferon regulatory factor 7 (IRF7). We hypothesize that during EBV latency, LMP1 induces the sumoylation of IRF7, limiting its transcriptional activity and modulating the activation of innate immune responses. Our data show that endogenously sumoylated IRF7 is detected in latently infected EBV lymphoblastoid cell lines. LMP1 expression coincided with increased sumoylation of IRF7 in a CTAR3-dependent manner. Additional experiments show that LMP1 CTAR3-induced sumoylation regulates the expression and function of IRF7 by decreasing its turnover, increasing its nuclear retention, decreasing its DNA binding, and limiting its transcriptional activation. Finally, we identified that IRF7 is sumoylated at lysine 452. These data demonstrate that LMP1 CTAR3 does in fact function in intracellular signaling, leading to biologic effects. We propose that CTAR3 is an important signaling region of LMP1 that regulates protein function by sumoylation. We have shown specifically that LMP1 CTAR3, in cooperation with CTAR2, can limit the ability of IRF7 to induce innate immune responses by inducing the sumoylation of IRF7.
Influence of graphene-substrate interactions on configurations of organic molecules on graphene: pentacene/epitaxial graphene/SiC
Creators: name: Jung, W.
name: Oh, D. -H.
name: Song, I.
name: Shin, H. -C.
name: Ahn, S. J.
name: Moon, Y.
name: Park, C. -Y.
name: Ahn, J. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Pentacene has been used widely in organic devices, and the interface structure between pentacene and a substrate is known to significantly influence device performances. Here we demonstrate that molecular ordering of pentacene on graphene depends on the interaction between graphene and its underlying SiC substrate. The adsorption of pentacene molecules on zero-layer and single-layer graphene, which were grown on a Sifaced 6H-SiC(0001) wafer, was studied using scanning tunneling microscopy (STM). Pentacene molecules form a quasi-amorphous layer on zero-layer graphene which interacts strongly with the underlying SiC substrate. In contrast, they form a uniformly ordered layer on the single-layer graphene having a weak graphene-SiC interaction. Furthermore, we could change the configuration of pentacene molecules on the singlelayer graphene by using STM tips. The results suggest that the molecular ordering of pentacene on graphene and the pentacene/graphene interface structure can be controlled by a graphene-substrate interaction.
description: 13 pages, 4 figures
Many-body characterization of topological superconductivity: The Richardson-Gaudin-Kitaev chain
Creators: name: Ortiz, Gerardo
name: Dukelsky, Jorge
name: Cobanera, Emilio
name: Esebbag, Carlos
name: Beenakker, Carlo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: Mathematical Physics (math-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: What distinguishes trivial from topological superluids in interacting many-body systems where the number of particles is conserved? Building on a class of integrable pairing Hamiltonians, we present a number-conserving, interacting variation of the Kitaev model, the Richardson-Gaudin-Kitaev chain, that remains exactly solvable for periodic and antiperiodic boundary conditions. Our model allows us to identify fermionic parity switches that distinctively characterize topological superconductivity in interacting many-body systems. Although the Majorana zero-modes in this model have only a power-law confinement, we may still define many-body Majorana operators by tuning the flux to a fermion parity switch. We derive a closed-form expression for an interacting topological invariant and show that the transition away from the topological phase is of third order.
description: 5 pages, 2 figures
Low-temperature illumination and annealing of ultra-high quality quantum wells
Creators: name: Samani, Mohammad
name: Rossokhaty, Alexander V.
name: Sajadi, Ebrahim
name: Lüscher, Silvia
name: Folk, Joshua A.
name: Watson, John D.
name: Gardner, Geoffrey C.
name: Manfra, Michael J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The effects of low temperature illumination and annealing on fractional quantum Hall (FQH) characteristics of a GaAs/AlGaAs quantum well are investigated. Illumination alone, below 1 K, decreases the density of the 2DEG electrons by more than an order of magnitude and resets the sample to a repeatable initial state. Subsequent thermal annealing at a few Kelvin restores the original density and dramatically improves FQH characteristics. A reliable illumination and annealing recipe is developed that yields an energy gap of 600 mK for the 5/2 state.
Epstein-Barr Virus Latent Membrane Protein-2A Induces ITAM/Syk- and Akt-Dependent Epithelial Migration through  V-Integrin Membrane Translocation
Creators: name: Raab-Traub, N.
name: Coalson, N. E.
name: Fotheringham, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Epstein-Barr virus (EBV) is a highly prevalent herpesvirus associated with epithelial cancers, including nasopharyngeal carcinoma (NPC). The EBV protein latent membrane protein 2 (LMP2) is expressed in NPC tumor tissue and has been shown to induce transformation, inhibit differentiation, and promote migration of epithelial cells. In this study, the effect of LMP2A on migration of human epithelial cells was further analyzed. LMP2A expression induced migration in human foreskin keratinocytes (HFK) and HaCaT keratinocytes measured by wound healing scratch assay and chemoattractant-induced Transwell migration assay. The induction of migration by LMP2A required the ITAM signaling domain of LMP2A and activation of the Syk tyrosine kinase. LMP2A-induced Transwell migration required the Akt signaling pathway, and activation of Akt by LMP2A required the ITAM signaling domain of LMP2A. LMP2A also induced phosphorylation of the Akt target GSK3β, a Wnt signaling mediator that has been shown to regulate the activity of focal adhesion kinase (FAK), a tyrosine kinase activated by clustering and ligand interaction of integrins. Inhibition of either FAK or its signaling mediator Src kinase inhibited LMP2A-induced migration. Interestingly, αV-integrin was greatly increased in membrane-enriched fractions by LMP2A, and a neutralizing antibody to αV-integrin blocked migration, suggesting that the effects of LMP2A on membrane-localized αV-integrin promoted migration. The results of this study indicate that LMP2A expression in human epithelial cells induces αV-integrin-dependent migration through a mechanism requiring ITAM-mediated Syk and Akt activation and inducing membrane translocation or stabilization of αV-integrin and FAK activation. The specific effects of LMP2A on an integrin with a diverse repertoire of ligand specificities could promote migration of different cell types and be initiated by multiple chemoattractants.
Near-Field Optical control of Doughnut-Shaped Nanostructures
Creators: name: Dubrovkin, A. M.
name: Barille, R.
name: Ortyl, E.
name: Zielinska, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The application of a local near-field optical excitation can be used to control step-by-step the reshape of individual doughnut-shaped azopolymer nano-objects by varying the time of illumination demonstrating its promising performance as a functional nano-object. The possibility to provide both photoinduced reshaping opens a way to the fundamental study of size-dependent scaling laws of optical properties, photoinduced reshaping efficiency and nanoreactor or nanoresonator behavior at nanometer scale. As an example the nano-object is used to self-assembly polystyrene nanospheres in a supraball.
description: 15 pages, 6 figures
Unexpected correlations in outstanding subpopulations of the gravitational-wave transient catalogue data
Creators: name: Kruckow, Matthias
Publisher: name: Zenodo
Year: 2022

description: With the third observing run the number of gravitational wave emitting events has increased significantly. The data of the recorded events is inspected to search for overall properties on the population. The properties of subpopulations are determined and compared to predictions from simulations. It appears that the most outstanding systems follow linear relations in the parameter space of the total binary and the chirp mass. Those relations are too tight to have a stochastic origin and are supported by at least five independent events each. The origin of the correlations is still open to be confirmed, while possible sources, ranging from instrumental artefacts to unknown physics, are discussed and partly excluded. Depending on the relation’s source the two events (GW190814 and GW200210_092254) having a smaller mass component between 2.5 and 2.9 Msun may reveal in a very different light.
description: {"references": ["Matthias U. Kruckow and Zhanwen Han (2021), arXiv:2112.07847"]}
Design of a silica-aerogel-based cosmic dust collector for the Tanpopo mission aboard the International Space Station
Creators: name: Tabata, Makoto
name: Imai, Eiichi
name: Yano, Hajime
name: Hashimoto, Hirofumi
name: Kawai, Hideyuki
name: Kawaguchi, Yuko
name: Kobayashi, Kensei
name: Mita, Hajime
name: Okudaira, Kyoko
name: Sasaki, Satoshi
name: Yabuta, Hikaru
name: Yokobori, Shin-ichi
name: Yamagishi, Akihiko
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We are developing a silica-aerogel-based cosmic dust collector for use in the Tanpopo experiment to be conducted on the International Space Station. The mass production of simple two-layer hydrophobic aerogels was undertaken in a contamination-controlled environment, yielding more than 100 undamaged products. The collector, comprising an aerogel tile and holder panel, was designed to resist launch vibration and to conform to an exposure attachment. To this end, a box-framing aerogel with inner and outer densities of 0.01 and 0.03 g/cm$^3$, respectively, was fabricated. The aerogel mounted in the panel passed random vibration tests at the levels of the acceptance and qualification tests for launch. It also withstood the pressure changes expected in the airlock on the International Space Station.
description: To be published in Trans. JSASS Aerospace Tech. Japan, 6 pages, 6 figures
A look at the 1.8-2.2 Ga zircon distribution as a paleogeographic and provenance indicator for peri-Gondwanan terranes
Creators: name: Lains Amaral, João
name: Solá, Ana Rita
name: Bento dos Santos, Telmo M.
name: Chichorro, Martim
Publisher: name: Zenodo
Year: 2022

description: The Paleoproterozoic orogenies are among the most significant crustal growth events recorded in Western Gondwana, as depicted by their strong detrital zircon signature into the Gondwanan and peri-Gondwanan sediments. Indeed, the Neoproterozoic–Cambrian sediments of peri-Gondwanan terranes, particularly those in Iberia, Meguma, Avalonia, and Ganderia, display distinctive 2.2–1.8 Ga zircon distributions. In the Iberian Massif, the Galicia-Trás-os-Montes (upper allochthonous) and Ossa-Morena zones present distinctive 1.95–1.9 and 2.1–2.05 Ga peaks, whereas West Asturian-Leonese and Cantabrian zones show a prominent ~2.0 Ga peak. The Centro-Iberian Zone also has a curve centred at 2.0 Ga but of greater wavelength. In contrast, the Avalonian and Ganderia sediments show multiple peaks between ~1.6 and ~2.1 Ga, whereas Meguma has a distinctive ~2.05 Ga peak. These unique distributions are most likely paleogeographic indicators of the diachronic Paleoproterozoic orogenic events from the western blocks (Amazonian Craton) to the eastern blocks (Sahara Metacraton) of Gondwana. Indeed, in the Amazonian and the North African Precambrian regions, the magmatic-metamorphic Paleoproterozoic events are mainly constrained to: (1) ~2.0–1.6 Ga in the western Amazonian provinces, (2) ~2.2–2.0 Ga in the Transamazonian province, (3) ~2.2–2.0 Ga in the West African Craton, (4) ~2.1–1.9 Ga in the Trans-Sahara Belt, and (5) ~2.0 Ga in the Sahara Metacraton. Furthermore, North African sedimentary rocks show peaks within 2.1–2.05 Ga in the western block, while eastern blocks show peaks within 2.1–1.9 Ga, which are generally congruent with adjacent cratonic orogenic events. Indeed: (1) Anti-Atlas Tonian-middle Cambrian sedimentary rocks show prominent 2.1–2.05 Ga peaks, coincident with the 2.1–2.05 Ga event in West African Craton, (2) Trans-Sahara Belt Ordovician sedimentary rocks display ~1.75, ~1.9 and ~2.1 Ga peaks congruent with the ~1.9 Ga event present in the basement inlier of this belt, and (3) Sahara Metacraton Tonian sedimentary rocks present a ~2.0 Ga peak consistent with the main 2.0 Ga event in this metacraton. However, Sahara Metacraton Cambrian rocks show 1.85 and 2.05 Ga peaks, most likely suggesting provenance from Trans-Sahara Belt or that these orogenic events have not yet been adequately identified in this metacraton. The 2.2–1.8 Ga zircon distribution is, in some cases, a distinctive feature throughout the Palaeozoic. For example, the middle-upper Devonian sediments of the Iberian Pyrite Belt display a prominent ~2.1 Ga peak, similar to the West African Craton, Anti-Atlas and Meguma, which do not occur in any of the other Iberian zones
Flowing holographic anyonic superfluid
Creators: name: Jokela, Niko
name: Lifschytz, Gilad
name: Lippert, Matthew
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the flow of a strongly coupled anyonic superfluid based on the holographic D3-D7' probe brane model. By analyzing the spectrum of fluctuations, we find the critical superfluid velocity, as a function of the temperature, at which the flow stops being dissipationless when flowing past a barrier. We find that at a larger velocity the flow becomes unstable even in the absence of a barrier.
description: 24 pages, 7 figures
A Program for the Improvement and Elaboration of Data Needed for Commodity Price Forecasting
Creators: name: Stine, O. C.
name: Stine, O. C.
Publisher: name: Unknown
Year: 1929
Subjects: Demand and Price Analysis
Research Methods/ Statistical Methods

description: Excerpts: I know that some of you do not believe in price forecasting. But many of us are engaged in aiding producers to adjust production to demand and in deciding when and how to market; or in aiding distributors and consumers to decide when to buy. We are trying to make some practical use of economic theory and statistics. Whether we acknowledge it or not, we are forecasting or aiding our employers to forecast prices. As a basis for price forecasting we need and must have greater precision in price analysis. Availability and character of data largely determine what can be done. The economic statistician can not make bricks without straw, the opinion of many to the contrary notwithstanding. Although we have a great mass of commodity statistics, the analyst is always confronted with the need of something more or better.
description: Address, Joint Meeting of the American Economic Association, the American Statistical Association, and the American Farm Economic Association, Washington, D. C., December 28, 1929. By O. C. Stine, Principal Agricultural Economist, Division of Statistical and Historical Research, Bureau of Agricultural Economics.
Automating eclipsing binary light curve analysis: From TESS raw light curve to orbital configuration
Creators: name: IJspeert, Luc
name: Tkachenko, Andrew
name: Johnston, Cole
name: Aerts, Conny
Publisher: name: Zenodo
Year: 2022

description: Analysing and modelling thousands of eclipsing binary light curves is a methodologically and computationally challenging endeavour, certainly in the presence of intrinsic variability. With this poster, we present a conceptually new automated method designed to provide realistic estimates of fundamental orbital parameters of eclipsing binary systems, even in the presence of intrinsic stellar variability.
description: Poster 7
Epstein-Barr Virus-Encoded Latent Membrane Protein 1 (LMP1) and LMP2A Function Cooperatively To Promote Carcinoma Development in a Mouse Carcinogenesis Model
Creators: name: Moore, D. T.
name: Bendt, K. M.
name: Shair, K. H. Y.
name: Edwards, R. H.
name: Nielsen, J. N.
name: Raab-Traub, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Epstein-Barr virus (EBV) proteins latent membrane proteins 1 and 2 (LMP1 and LMP2) are frequently expressed in EBV-associated lymphoid and epithelial cancers and have complex effects on cell signaling and growth. The effects of these proteins on epithelial cell growth were assessed in vivo using transgenic mice driven by the keratin 14 promoter (K14). The development of papillomas and carcinomas was determined in the tumor initiator and promoter model using dimethyl benzanthracene (DMBA), followed by repeated treatments of 12-O-tetradecanoyl phorbol 13-acetate (TPA). In these assays, LMP1 functioned as a weak tumor promoter and increased papilloma formation. In contrast, mice expressing LMP2A did not induce or promote papilloma formation. Transgenic LMP1 mice had slightly increased development of squamous cell carcinoma; however, the development of carcinoma was significantly increased in the doubly transgenic mice expressing both LMP1 and LMP2A. DMBA treatment induces an activating mutation in the Harvey-ras (H-ras61) oncogene, and this mutation was identified in most papillomas and carcinomas although several papillomas and carcinomas in K14-LMP1 and K14-LMP1/LMP2A mice lacked the mutation. Analysis of signaling pathways that are known to be activated by LMP1 and/or LMP2 indicated that all genotypes had high levels of activated extracellular signal-regulated kinase (ERK) and Stat3 in carcinomas with significantly higher activation in the doubly transgenic carcinomas. These findings suggest that, in combination, LMP1 and LMP2 contribute to carcinoma progression and that this may reflect the combined effects of the proteins on activation of multiple signaling pathways. This study is the first to characterize the effects of LMP2 on tumor initiation and promotion and to identify an effect of the combined expression of LMP1 and LMP2 on the increase of carcinoma development.
Tate tame symbol and the joint torsion of commuting operators
Creators: name: Kaad, Jens
name: Nest, Ryszard
Publisher: name: arXiv
Year: 2014
Subjects: subject: K-Theory and Homology (math.KT)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A13, 32A10

description: We investigate determinants of Koszul complexes of holomorphic functions of a commuting tuple of bounded operators acting on a Hilbert space. Our main result shows that the analytic joint torsion, which compares two such determinants, can be computed by a local formula which involves a tame symbol of the involved holomorphic functions. As an application we are able to extend the classical tame symbol of meromorphic functions on a Riemann surface to the more involved setting of transversal functions on a complex analytic curve. This follows by spelling out our main result in the case of Toeplitz operators acting on the Hardy space over the polydisc.
description: 26 pages
MIMO-MC Radar: A MIMO Radar Approach Based on Matrix Completion
Creators: name: Sun, Shunqiao
name: Bajwa, Waheed U.
name: Petropulu, Athina P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: In a typical MIMO radar scenario, transmit nodes transmit orthogonal waveforms, while each receive node performs matched filtering with the known set of transmit waveforms, and forwards the results to the fusion center. Based on the data it receives from multiple antennas, the fusion center formulates a matrix, which, in conjunction with standard array processing schemes, such as MUSIC, leads to target detection and parameter estimation. In MIMO radars with compressive sensing (MIMO-CS), the data matrix is formulated by each receive node forwarding a small number of compressively obtained samples. In this paper, it is shown that under certain conditions, in both sampling cases, the data matrix at the fusion center is low-rank, and thus can be recovered based on knowledge of a small subset of its entries via matrix completion (MC) techniques. Leveraging the low-rank property of that matrix, we propose a new MIMO radar approach, termed, MIMO-MC radar, in which each receive node either performs matched filtering with a small number of randomly selected dictionary waveforms or obtains sub-Nyquist samples of the received signal at random sampling instants, and forwards the results to a fusion center. Based on the received samples, and with knowledge of the sampling scheme, the fusion center partially fills the data matrix and subsequently applies MC techniques to estimate the full matrix. MIMO-MC radars share the advantages of the recently proposed MIMO-CS radars, i.e., high resolution with reduced amounts of data, but unlike MIMO-CS radars do not require grid discretization. The MIMO-MC radar concept is illustrated through a linear uniform array configuration, and its target estimation performance is demonstrated via simulations.
description: 29 pages, 13 figures, IEEE Trans. on Aerospace and Electronic Systems
Supernovae in colliding-wind binaries: observational signatures in the first year
Creators: name: Pejcha, Ondřej
name: Calderón, Diego
name: Kurfürst, Petr
Publisher: name: Zenodo
Year: 2022
Subjects: Binaries
Massive stars
Supernovae
Stellar winds

description: When a core-collapse supernova (SN) explodes in a binary star system, the ejecta might encounter an overdense shell, where the stellar winds of the two stars previously collided. In this work, we investigate effects of such interactions on SN light curves on time-scales from the early flash ionisation signatures to approximately one year after the explosion.
description: {"references": ["Calder\u00f3n D. et al., 2020, MNRAS 493, 447", "Eldridge J. J. et al., 2017, PASA, 34, e058", "Kochanek C. S., 2019, MNRAS, 483, 3762", "Kurf\u00fcrst P. et al., 2020, A&A, 642, A214", "Pejcha O. & Prieto J. L., 2015, ApJ, 799, 215", "Morries T. & Podsiadlowski P., 2007, Science, 315, 1103", "Teyssier R., 2002, A&A, 385, 337", "Wu S. & Fuller J., 2021, ApJ, 906, 3"]}
Generation of HIV Latency in Humanized BLT Mice
Creators: name: Krisko, J. F.
name: Garcia, J. V.
name: Spagnuolo, R. A.
name: Swanson, M. D.
name: Denton, P. W.
name: Wahl, A.
name: Chateau, M.
name: Archin, N. M.
name: Nochi, T.
name: Olesen, R.
name: Margolis, D. M.
name: Choudhary, S. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4+ T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting human CD4+ T cells present in BLT mice are within the range of those observed circulating in patients undergoing suppressive ART. These results demonstrate the potential of humanized BLT mice as an attractive model for testing the in vivo efficacy of novel HIV eradication strategies.
Globular Clusters and Dark Satellite Galaxies through the Stream Velocity
Creators: name: Naoz, Smadar
name: Narayan, Ramesh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The formation of purely baryonic globular clusters with no gravitationally bound dark matter is still a theoretical challenge. We show that these objects might form naturally whenever there is a relative stream velocity between baryons and dark matter. The stream velocity causes a phase shift between linear modes of baryonic and dark matter perturbations, which translates to a spatial offset between the two components when they collapse. For a 2sigma (3sigma) density fluctuation, baryonic clumps with masses in the range 1e5 - 2.5e6 Msun (1e5 - 4e6 Msun) collapse outside the virial radii of their counterpart dark matter halos. These objects could survive as long-lived dark matter-free objects and might conceivably become globular clusters. In addition, their dark matter counterparts, which were deprived of gas, might become dark satellite galaxies.
description: 3 Figures, accepted for publication in ApJ Letters
The Role of Large-Scale Fading in Uplink Massive MIMO Systems
Creators: name: Yang, Ang
name: He, Zunwen
name: Xing, Chengwen
name: Fei, Zesong
name: Kuang, Jingming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this correspondence, we analyze the ergodic capacity of a large uplink multi-user multiple-input multiple-output (MU-MIMO) system over generalized-$K$ fading channels. In the considered scenario, multiple users transmit their information to a base station equipped with a very large number of antennas. Since the effect of fast fading asymptotically disappears in massive MIMO systems, large-scale fading becomes the most dominant factor for the ergodic capacity of massive MIMO systems. Regarding this fact, in our work we concentrate our attention on the effects of large-scale fading for massive MIMO systems. Specifically, some interesting and novel lower bounds of the ergodic capacity have been derived with both perfect channel state information (CSI) and imperfect CSI. Simulation results assess the accuracy of these analytical expressions.
description: Submitted to IEEE Transactions on Vehicular Technology as a correspondence
title: Comparison of control and toxic reference data between honey bee laboratory studies conducted in Germany and in Spain over the Last Decade
Creators: name: Vergé, Emmanuelle
name: Ansaloni, Tommaso
name: Solitor, Anna Maria
name: Oberrauch, Sophia
name: Kling, Annette
Publisher: name: Julius Kühn-Institut
Year: 2018

description: The Draft EFSA Bee Guidance Document (2013) describes various types of bee studies to be part of the risk assessment. Eurofins Agroscience Services (EAS) has been conducting acute toxicity and chronic feeding studies with adult bees over the last decade and larval acute and chronic studies over the last 5 years in Germany and in Spain. The studies are conducted with different subspecies and in different times of the year in the two countries.
The aim of the comparison is to find out if season and geographical origin of the bees have any influence on the test outcome, i.e. control/solvent control mortality and reference item 24 h LD50 range with controls and toxic reference data collected over multiple years. The results give an indication how relevant the testing of different subspecies is for the registration of plant protection products in Europe.
description: Julius-Kühn-Archiv, Nr. 462 (2018): Hazards of pesticides to bees 13th International Symposium of the ICP-PR Bee Protection Group 18. - 20. October 2017, València (Spain) - Proceedings -
Genetic Mapping of a Highly Variable Norovirus GII.4 Blockade Epitope: Potential Role in Escape from Human Herd Immunity
Creators: name: Debbink, K.
name: Baric, R. S.
name: Donaldson, E. F.
name: Lindesmith, L. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Noroviruses account for 96% of viral gastroenteritis cases worldwide, with GII.4 strains responsible >80% of norovirus outbreaks. Histo-blood group antigens (HBGAs) are norovirus binding ligands, and antigenic and preferential HBGA binding profiles vary over time as new GII.4 strains emerge. The capsid P2 subdomain facilitates HBGA binding, contains neutralizing antibody epitopes, and likely evolves in response to herd immunity. To identify amino acids regulating HBGA binding and antigenic differences over time, we created chimeric virus-like particles (VLPs) between the GII.4-1987 and GII.4-2006 strains by exchanging amino acids in putative epitopes and characterized their antigenic and HBGA binding profiles using anti-GII.4-1987 and -2006 mouse monoclonal antibodies (MAbs) and polyclonal sera, 1988 outbreak human sera, and synthetic HBGAs. The exchange of amino acids 393 to 395 between GII.4-1987 and GII.4-2006 resulted in altered synthetic HBGA binding compared to parental strains. Introduction of GII.4-1987 residues 294, 297 to 298, 368, and 372 (epitope A) into GII.4-2006 resulted in reactivity with three anti-GII.4-1987 MAbs and reduced reactivity with four anti-GII.4-2006 MAbs. The three anti-GII.4-1987 MAbs also blocked chimeric VLP-HBGA interaction, while an anti-GII.4-2006 blocking antibody did not, indicating that epitope A amino acids comprise a potential neutralizing epitope for GII.4-1987 and GII.4-2006. We also tested GII.4-1987-immunized mouse polyclonal sera and 1988 outbreak human sera for the ability to block chimeric VLP-HBGA interaction and found that epitope A amino acids contribute significantly to the GII.4-1987 blockade response. Our data provide insights that help explain the emergence of new GII.4 epidemic strains over time, may aid development of norovirus therapeutics, and may help predict the emergence of future epidemic strains.
Leitungsgewalt der Römischen Kurie gemäß der Apostolischen Konstitution Praedicate Evangelium
Creators: name: Viana, Antonio
name: Berkmann, Burkhard
Publisher: name: NomoK@non
Year: 2023

description: Zusammenfassung: Der Artikel ist ein erster Kommentar zu der neuen Apostolischen Konstitution über die Reform der Römischen Kurie „Praedicate Evangelium“. Ausgehend von den Vorarbeiten zu dem Dokument gibt der Autor erste rekonstruierende Einblicke in dessen Inhalt. Riassunto: L’articolo costituisce un primo commento alla nuova costituzione apostolica di riforma della Curia romana, "Praedicate Evangelium". Partendo dai lavori preparatori del documento l’autore fornisce dei primi spunti ricostruttivi circa i contenuti del documento.
description: NomoK@non, Fachartikel
Glycan Binding Avidity Determines the Systemic Fate of Adeno-Associated Virus Type 9
Creators: name: Bryant, K. D.
name: Sun, J.
name: Brown, S. M.
name: Pulicherla, N.
name: Asokan, A.
name: Troupes, A.
name: Shen, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Glycans are key determinants of host range and transmissibility in several pathogens. In the case of adeno-associated viruses (AAV), different carbohydrates serve as cellular receptors in vitro; however, their contributions in vivo are less clear. A particularly interesting example is adeno-associated virus serotype 9 (AAV9), which displays systemic tropism in mice despite low endogenous levels of its primary receptor (galactose) in murine tissues. To understand this further, we studied the effect of modulating glycan binding avidity on the systemic fate of AAV9 in mice. Intravenous administration of recombinant sialidase increased tissue levels of terminally galactosylated glycans in several murine tissues. These conditions altered the systemic tropism of AAV9 into a hepatotropic phenotype, characterized by markedly increased sequestration within the liver sinusoidal endothelium and Kupffer cells. In contrast, an AAV9 mutant with decreased glycan binding avidity displayed a liver-detargeted phenotype. Altering glycan binding avidity also profoundly affected AAV9 persistence in blood circulation. Our results support the notion that high glycan receptor binding avidity appears to impart increased liver tropism, while decreased avidity favors systemic spread of AAV vectors. These findings may not only help predict species-specific differences in tropism for AAV9 on the basis of tissue glycosylation profiles, but also provide a general approach to tailor AAV vectors for systemic or hepatic gene transfer by reengineering capsid-glycan interactions.
Continuous Flavor Symmetries and the Stability of Asymmetric Dark Matter
Creators: name: Bishara, Fady
name: Zupan, Jure
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Generically, the asymmetric interactions in asymmetric dark matter (ADM) models lead to decaying DM. We show that, for ADM that carries nonzero baryon number, the continuous flavor symmetries that generate the flavor structure in the quark sector also imply a looser lower bound on the mass scale of the asymmetric mediators between the dark and visible sectors. The mediators for $B=2$ ADM that can produce a signal in the future indirect dark matter searches can thus also be searched for at the LHC. For two examples of the mediator models, with either the MFV or Froggatt-Nielsen flavor breaking pattern, we derive the FCNC constraints and discuss the search strategies at the LHC.
description: 41 pages, 10 figures
Human Galectin 3 Binding Protein Interacts with Recombinant Adeno-Associated Virus Type 6
Creators: name: Moullier, P.
name: Blot, S.
name: Denard, J.
name: Beley, C.
name: Svinartchouk, F.
name: Voit, T.
name: Garcia, L.
name: Lai-Kuen, R.
name: Asokan, A.
name: Kotin, R.
name: Samulski, R. J.
name: Leh, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recombinant adeno-associated viruses (rAAVs) hold enormous potential for human gene therapy. Despite the well-established safety and efficacy of rAAVs for in vivo gene transfer, there is still little information concerning the fate of vectors in blood following systemic delivery. We screened for serum proteins interacting with different AAV serotypes in humans, macaques, dogs, and mice. We report that serotypes rAAV-1, -5, and -6 but not serotypes rAAV-2, -7, -8, -9, and -10 interact in human sera with galectin 3 binding protein (hu-G3BP), a soluble scavenger receptor. Among the three serotypes, rAAV-6 has the most important capacities for binding to G3BP. rAAV-6 also bound G3BP in dog sera but not in macaque and mouse sera. In mice, rAAV-6 interacted with another protein of the innate immune system, C-reactive protein (CRP). Furthermore, interaction of hu-G3BP with rAAV-6 led to the formation of aggregates and hampered transduction when the two were codelivered into the mouse. Based on these data, we propose that species-specific interactions of AAVs with blood proteins may differentially impact vector distribution and efficacy in different animal models.
Additional file 1 of Phthalates and bone mineral density: a systematic review
Creators: name: Heilmann, Nina Z.
name: Reeves, Katherine W.
name: Hankinson, Susan E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Systematic approach to critiquing epidemiologic studies.
Human Papillomaviruses Recruit Cellular DNA Repair and Homologous Recombination Factors to Viral Replication Centers
Creators: name: Gillespie, K. A.
name: Moody, C. A.
name: Laimins, L. A.
name: Mehta, K. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Human papillomaviruses (HPV) activate the ataxia telangiectasia mutated (ATM)-dependent DNA damage response to induce viral genome amplification upon epithelial differentiation. Our studies show that along with members of the ATM pathway, HPV proteins also localize factors involved in homologous DNA recombination to distinct nuclear foci that contain HPV genomes and cellular replication factors. These studies indicate that HPV activates the ATM pathway to recruit repair factors to viral genomes and allow for efficient replication.
Multifractal characteristics of optical turbulence measured through a single beam holographic process
Creators: name: Perez, Dario G.
name: Barille, Regis
name: Morille, Yohann
name: Zielinska, Sonia
name: Ortyl, Ewelina
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We have previously shown that azopolymer thin films exposed to coherent light that has travelled through a turbulent medium produces a surface relief grating containing information about the intensity of the turbulence; for instance, a relation between the refractive index structure constant C2 as a function of the surface parameters was obtained. In this work, we show that these films capture much more information about the turbulence dynamics. Multifractal detrended fluctuation and fractal dimension analysis from images of the surface roughness produced by the light on the azopolymer reveals scaling properties related to those of the optical turbulence.
description: 8 pages, 5 figures
Initial HIV-1 Antigen-Specific CD8+ T Cells in Acute HIV-1 Infection Inhibit Transmitted/Founder Virus Replication
Creators: name: Freel, S. A.
name: Picking, R. A.
name: Denny, T. N.
name: McMichael, A. J.
name: Kirchherr, J. L.
name: Crump, J. A.
name: Weinhold, K. J.
name: Cunningham, C. K.
name: Cohen, M. S.
name: Ochsenbauer, C.
name: Kappes, J. C.
name: Tomaras, G. D.
name: Ding, H.
name: Ferrari, G.
name: Soderberg, K. A.
name: Haynes, B. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: CD8-mediated virus inhibition can be detected in HIV-1-positive subjects who naturally control virus replication. Characterizing the inhibitory function of CD8+ T cells during acute HIV-1 infection (AHI) can elucidate the nature of the CD8+ responses that can be rapidly elicited and that contribute to virus control. We examined the timing and HIV-1 antigen specificity of antiviral CD8+ T cells during AHI. Autologous and heterologous CD8+ T cell antiviral functions were assessed longitudinally during AHI in five donors from the CHAVI 001 cohort using a CD8+ T cell-mediated virus inhibition assay (CD8 VIA) and transmitted/founder (T/F) viruses. Potent CD8+ antiviral responses against heterologous T/F viruses appeared during AHI at the first time point sampled in each of the 5 donors (Fiebig stages 1/2 to 5). Inhibition of an autologous T/F virus was durable to 48 weeks; however, inhibition of heterologous responses declined concurrent with the resolution of viremia. HIV-1 viruses from 6 months postinfection were more resistant to CD8+-mediated virus inhibition than cognate T/F viruses, demonstrating that the virus escapes early from CD8+ T cell-mediated inhibition of virus replication. CD8+ T cell antigen-specific subsets mediated inhibition of T/F virus replication via soluble components, and these soluble responses were stimulated by peptide pools that include epitopes that were shown to drive HIV-1 escape during AHI. These data provide insights into the mechanisms of CD8-mediated virus inhibition and suggest that functional analyses will be important for determining whether similar antigen-specific virus inhibition can be induced by T cell-directed vaccine strategies.
Additional file 1 of Patient satisfaction with pharmacist-administered COVID-19 vaccines in Poland: a survey study in the vaccination centres context
Creators: name: Merks, Piotr
name: Kowalczuk, Anna
name: Wong, Alexandre
name: Chung, Kevin
name: Religioni, Urszula
name: Świetlik, Dariusz
name: Rotmans-Plagens, Katarzyna
name: Cameron, Jameason
name: Sola, Katarina Fehir
name: Kazmierczak, Justyna
name: Blicharska, Eliza
name: Vaillancourt, Regis
name: Neumann-Podczaska, Agnieszka
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Questionnaire
Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2-/-  c-/- Mouse
Creators: name: Dahl, N. P.
name: Margolis, D. M.
name: Cheema, M.
name: Garcia, J. V.
name: Archin, N. M.
name: Choudhary, S. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Persistent human immunodeficiency virus type 1 (HIV-1) infection of resting CD4+ T cells, unaffected by antiretroviral therapy (ART), provides a long-lived reservoir of HIV infection. Therapies that target this viral reservoir are needed to eradicate HIV-1 infection. A small-animal model that recapitulates HIV-1 latency in resting CD4+ T cells may accelerate drug discovery and allow the rational design of nonhuman primate (NHP) or human studies. We report that in humanized Rag2−/− γc−/− (hu-Rag2−/− γc−/−) mice, as in humans, resting CD4+ T cell infection (RCI) can be quantitated in pooled samples of circulating cells and tissue reservoirs (e.g., lymph node, spleen, bone marrow) following HIV-1 infection with the CCR5-tropic JR-CSF strain and suppression of viremia by ART. Replication-competent virus was recovered from pooled resting CD4+ T cells in 7 of 16 mice, with a median frequency of 8 (range, 2 to 12) infected cells per million T cells, demonstrating that HIV-1 infection can persist despite ART in the resting CD4+ T cell reservoir of hu-Rag2−/− γc−/− mice. This model will allow rapid preliminary assessments of novel eradication approaches and combinatorial strategies that may be challenging to perform in the NHP model or in humans, as well as a rigorous analysis of the effect of these interventions in specific anatomical compartments.
Detection of 36 GHz class I methanol maser emission towards NGCS253
Creators: name: Ellingsen, Simon
name: Chen, Xi
name: Qiao, Hai-Hua
name: Baan, Willem
name: An, Tao
name: Li, Juan
name: Breen, Shari
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have used the Australia Telescope Compact Array (ATCA) to search for emission from the $4_{-1} \rightarrow 3_{0}E$ transition of methanol (36.2 GHz) towards the center of the nearby starburst galaxy NGC253. Two regions of emission were detected, offset from the nucleus along the same position angle as the inner spiral arms. The emission is largely unresolved on a scale of 5 arcsec, has a full-width half maximum (FWHM) line width of < 30 km s$^{-1}$, and an isotropic luminosity orders of magnitude larger than that observed in any Galactic star formation regions. These characteristics suggest that the 36.2 GHz methanol emission is most likely a maser, although observations with higher angular and spectral resolution are required to confirm this. If it is a maser this represents the first detection of a class I methanol maser outside the Milky Way. The 36.2 GHz methanol emission in NGC253 has more than an order of magnitude higher isotropic luminosity than the widespread emission recently detected towards the center of the Milky Way. If emission from this transition scales with nuclear star formation rate then it may be detectable in the central regions of many starburst galaxies. Detection of methanol emission in ultra-luminous infra-red galaxies (ULIRGs) would open up a new tool for testing for variations in fundamental constants (in particular the proton-to-electron mass ratio) on cosmological scales.
description: Accepted for publication in ApJ Letters, 5 pages, 2 figures
Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Monocytes Downregulates Expression of Adaptive Immune Response Costimulatory Receptors and Proinflammatory Cytokines
Creators: name: Dittmer, D. P.
name: Gregory, S. M.
name: West, J. A.
name: Damania, B.
name: Wang, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Kaposi's sarcoma-associated herpesvirus (KSHV) infection is associated with the development of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. We report the establishment of a monocytic cell line latently infected with KSHV (KSHV-THP-1). We profiled viral and cytokine gene expression in the KSHV-THP-1 cells compared to that in uninfected THP-1 cells and found that several genes involved in the host immune response were downregulated during latent infection, including genes for CD80, CD86, and the cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β). Thus, KSHV minimizes its immunological signature by suppressing key immune response factors, enabling persistent infection and evasion from host detection.
The primitive equations of the atmosphere in presence of vapor saturation
Creators: name: Zelati, Michele Coti
name: Huang, Aimin
name: Kukavica, Igor
name: Temam, Roger
name: Ziane, Mohammed
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: A modification of the classical primitive equations of the atmosphere is considered in order to take into account important phase transition phenomena due to air saturation and condensation. We provide a mathematical formulation of the problem that appears to be new in this setting, by making use of differential inclusions and variational inequalities, and which allows to develop a rather complete theory for the solutions to what turns out to be a nonlinearly coupled system of non-smooth partial differential equations. Specifically we prove global existence of quasi-strong and strong solutions, along with uniqueness results and maximum principles of physical interest.
description: 48 pages