cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.11.1953, erstellt von Wolfgang Gleissberg an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.12.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Women’s preferences for menstrual bleeding frequency in 12 European countries: the Inconvenience Due to Women’s Monthly Bleeding (ISY) survey
Creators: name: Fiala, Christian
name: Chabbert-Buffet, Nathalie
name: Häusler, Günther
name: Jamin, Christian
name: Lete, Iñaki
name: Lobo, Paloma
name: Nappi, Rossella E.
name: Pintiaux, Axelle
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Objectives: Our aim was to assess the level of inconvenience associated with menstrual bleeding and determine how many women across 12 European countries would prefer a bleeding frequency of less than once a month and what would motivate their choice. Methods: A 15-min quantitative online survey was conducted in two waves among 5728 women aged between 18 and 45 years, with an equal distribution of women using a combined hormonal contraceptive (CHC group, n = 2739) and women using a non-hormonal contraceptive or no contraceptive (non-HC group, n = 2989). The first wave was carried out in Austria, Belgium, France, Italy, Poland and Spain, in February 2015, and the results have been published. The second wave was conducted in the Czech Republic, Germany, Hungary, Portugal, Latvia and the Netherlands, between August and September 2015. Results: The menstrual period was significantly longer (5.0 versus 4.6 days) and heavier (15 versus 7%) in non-HC users than in CHC users (p < .0001). Given the choice, ∼60% of women would like less frequent menstrual bleeding. There was heterogeneity in the preference across countries. Sexuality, social life, work and sporting activities were key factors affecting women’s preference. Conclusion: The majority of women in the 12 European countries would prefer to reduce the frequency of menstrual periods. Quality of life was the main factor affecting their preference.
Insights into the structural dynamics of Liver kinase B1 (LKB1) by the binding of STe20 Related Adapterα (STRADα) and Mouse protein 25α (MO25α) co-activators
Creators: name: Ikrormi Rungsung
name: Amutha Ramaswamy
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Computational Biology

description: LKB1, the tumour suppressor, is found mutated in Peutz-Jeghers syndrome (PJS). The LKB1 is a serine-threonine kinase protein that is allosterically activated by the binding of STRADα and MO25α without phosphorylating the Thr212 present at activation loop. The present study aims to highlight the structural dynamics and complexation mechanism during the allosteric activation of LKB1 by these co-activators using molecular dynamics simulations. The all atom simulations performed on the complexes of LKB1 with ATP, STRADα, and MO25α for a period of 30 ns reveal that binding of STRADα and MO25α significantly stabilizes the highly flexible regions of LKB1 such as ATP binding region (β1-β2 loop), catalytic & activation loop segments and αG helix. Also, binding of STRADα and MO25α to LKB1 promotes coordinated motion between N- and C-lobes along with the catalytic & activation loops by forming H-bonds between LKB1 and co-activators, which further facilitate to establish the conserved attributes of active LKB1 such as (i) formation of salt bridge between Lys78 and Glu98, (ii) formation of stable hydrophobic R- and C-spines, and (iii) interaction between both catalytic and activation loops. Especially, the residues of LKB1 interacting with STRADα (Arg74, Glu342) and MO25α (Glu165, Pro203 and Phe204) are observed to play a significant role in stabilizing the (LKB1-ATP)-(STRADα-ATP)-MO25α complex. Overall, the present work highlighting the structural dynamics of LKB1 by the binding of allosteric co-activators is expected to provide a basic understanding on drug design specific to PJS syndrome.
Eotrogaspidia Lelej 1996
Creators: name: Williams, Kevin A.
name: Lelej, Arkady S.
name: Okayasu, Juriya
name: Borkent, Christopher J.
name: Malee, Rufeah
name: Thoawan, Kodeeyah
name: Thaochan, Narit
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mutillidae
Eotrogaspidia

description: Genus 22. Eotrogaspidia Lelej, 1996
Diagnosis. FEMALE. This genus has the procoxa armed with a tooth or smooth tubercle (Fig. 118), the scutellar scale present; the propodeum broader than the pronotum; the T2 disc with two pale lateral spots; T3 and T4 each with pale setal bands; and the pygidium defined, but not striate or entirely rugose. MALE. See Lelej (1996c).
Diversity and Distribution. Four Oriental species are recognized (Lelej 2005, Lelej & van Harten 2006), three are discussed below and one, E. ekka (Nurse, 1902), occurs in India.
Remarks. By having flattened and setose metacoxae in the male, this genus is similar to Vanhartenidia Lelej in Lelej & van Harten, 2006. In fact, one of the previously recognized Eotrogaspidia species, V. dives (Smith, 1855) was transferred into Vanhartenidia (Lelej & van Harten 2006). An interesting similarity in females of these genera is that the procoxa is armed with a tooth in both genera, although various other trogaspidiine genera have a similar tooth, including Wallacidia and many species within Trogaspidia itself.
In males, there are distinct genitalic differences between these genera and in females they can be separated by the coarsely sculpted pygidium of Vanhartenidia that has the lateral carina expanded apically (Lelej & van Harten 2006), while Eotrogaspidia have weaker pygidium sculpture and lateral carina (Figs 117, 121).
description: Published as part of Williams, Kevin A., Lelej, Arkady S., Okayasu, Juriya, Borkent, Christopher J., Malee, Rufeah, Thoawan, Kodeeyah & Thaochan, Narit, 2019, The female velvet ants (aka modkhong) of southern Thailand (Hymenoptera: Mutillidae), with a key to the genera of southeast Asia, pp. 1-69 in Zootaxa 4602 (1) on pages 31-32, DOI: 10.5281/zenodo.2669927
Sonnenfleckenzeichnung Nr. 18575.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.11.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.12.1953, erstellt von Mrkosova am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.11.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
The formation of catalytically competent enzyme–substrate complex is not a bottleneck in lesion excision by human alkyladenine DNA glycosylase
Creators: name: N.A. Kuznetsov
name: A.S. Kiryutin
name: A.A. Kuznetsova
name: M.S. Panov
name: M.O. Barsukova
name: A.V. Yurkovskaya
name: O.S. Fedorova
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Human alkyladenine DNA glycosylase (AAG) protects DNA from alkylated and deaminated purine lesions. AAG flips out the damaged nucleotide from the double helix of DNA and catalyzes the hydrolysis of the N-glycosidic bond to release the damaged base. To understand better, how the step of nucleotide eversion influences the overall catalytic process, we performed a pre-steady-state kinetic analysis of AAG interaction with specific DNA-substrates, 13-base pair duplexes containing in the 7th position 1-N6-ethenoadenine (εA), hypoxanthine (Hx), and the stable product analogue tetrahydrofuran (F). The combination of the fluorescence of tryptophan, 2-aminopurine, and 1-N6-ethenoadenine was used to record conformational changes of the enzyme and DNA during the processes of DNA lesion recognition, damaged base eversion, excision of the N-glycosidic bond, and product release. The thermal stability of the duplexes characterized by the temperature of melting, Tm, and the rates of spontaneous opening of individual nucleotide base pairs were determined by NMR spectroscopy. The data show that the relative thermal stability of duplexes containing a particular base pair in position 7, (Tm(F/T) Tm(εA/T) Tm(Hx/T) Tm(A/T)) correlates with the rate of reversible spontaneous opening of the base pair. However, in contrast to that, the catalytic lesion excision rate is two orders of magnitude higher for Hx-containing substrates than for substrates containing εA, proving that catalytic activity is not correlated with the stability of the damaged base pair. Our study reveals that the formation of the catalytically competent enzyme–substrate complex is not the bottleneck controlling the catalytic activity of AAG.
Krombeinidia Lelej 1996
Creators: name: Williams, Kevin A.
name: Lelej, Arkady S.
name: Okayasu, Juriya
name: Borkent, Christopher J.
name: Malee, Rufeah
name: Thoawan, Kodeeyah
name: Thaochan, Narit
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mutillidae
Krombeinidia

description: Genus 23. Krombeinidia Lelej, 1996
Diagnosis. FEMALE. This genus can be separated from other Oriental mutillids by the following combination of characters: propodeum narrower than or as broad as pronotum; scutellar scale distinct; T2 disc with two laterally disposed white to golden setal spots; T2 apex with narrow band of appressed white to golden setae; pygidium defined by lateral carinae and usually entirely smooth. The pygidium of Krombeinidia is usually narrower and more convex than Petersenidia. MALE. See Lelej (1996c).
Diversity and Distribution. This genus includes 24 species and is widespread in the Oriental region (Lelej 2005).
Remarks. This is the most diverse genus of the former tribe Petersenidiini (Trogaspidiini with males having symmetrical penis valves) in Southeast Asia with Krombeinidia meeungensis (Cockerell, 1928) being the only described species known from Thailand. The females are difficult to separate from Petersenidia, although the males can be reliably separated with genitalic features. Because the species described below are known from females only, molecular data or sex associations may eventually provide evidence to transfer them into different genera.
description: Published as part of Williams, Kevin A., Lelej, Arkady S., Okayasu, Juriya, Borkent, Christopher J., Malee, Rufeah, Thoawan, Kodeeyah & Thaochan, Narit, 2019, The female velvet ants (aka modkhong) of southern Thailand (Hymenoptera: Mutillidae), with a key to the genera of southeast Asia, pp. 1-69 in Zootaxa 4602 (1) on page 33, DOI: 10.5281/zenodo.2669927
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.11.1953, erstellt von L. am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Sonnenfleckenzeichnung Nr. 18527.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.09.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 18591.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.12.1953, erstellt von Adolf Lemans
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 18566.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.10.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 18555.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.10.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 18520.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.09.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 18511.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.08.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.12.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Amino acid composition analysis of human secondary transport proteins and implications for reliable membrane topology prediction
Creators: name: Saidijam, Massoud
name: Azizpour, Sonia
name: Patching, Simon G.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Secondary transporters in humans are a large group of proteins that transport a wide range of ions, metals, organic and inorganic solutes involved in energy transduction, control of membrane potential and osmotic balance, metabolic processes and in the absorption or efflux of drugs and xenobiotics. They are also emerging as important targets for development of new drugs and as target sites for drug delivery to specific organs or tissues. We have performed amino acid composition (AAC) and phylogenetic analyses and membrane topology predictions for 336 human secondary transport proteins and used the results to confirm protein classification and to look for trends and correlations with structural domains and specific substrates and/or function. Some proteins showed statistically high contents of individual amino acids or of groups of amino acids with similar physicochemical properties. One recurring trend was a correlation between high contents of charged and/or polar residues with misleading results in predictions of membrane topology, which was especially prevalent in Mitochondrial Carrier family proteins. We demonstrate how charged or polar residues located in the middle of transmembrane helices can interfere with their identification by membrane topology tools resulting in missed helices in the prediction. Comparison of AAC in the human proteins with that in 235 secondary transport proteins from Escherichia coli revealed similar overall trends along with differences in average contents for some individual amino acids and groups of similar amino acids that are presumed to result from a greater number of functions and complexity in the higher organism.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.10.1953, erstellt von Adnan Kiral an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.08.1953, erstellt von Gaston Coutrez, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung auf eigener, gedruckter Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Critical effects on binding of epidermal growth factor produced by amino acid substitutions
Creators: name: Masomeh Mehrabi
name: Khodarahmi, Reza
name: Shahlaei, Mohsen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Epidermal growth factor (EGF) plays important roles in multiple biological processes, such as the regulation of cell growth, proliferation, and differentiation. EGF exerts their pharmacologic effects via receptor-mediated mechanism associated with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. Overexpression of EGFR has been reported and implicated in the pathogenesis of many human cancers. The current study addresses the effects of mutations on binding properties of EGF to EGFR. Two mutant structures with three point mutations of conserved residues, Ile23, Arg41 and Leu47, which have been found to be important for the receptor binding, were built using homology modeling. The “wild type” (WT) and the mutant structures, after structural validations, were subjected to molecular dynamics simulations (MDSs). The primary aim of MDS was to investigate the possible impact of mutations on the protein structure and function. Analysis of root mean square deviation (RMSD), other time dependent structural properties and their averages provided some insights into the possible structural characteristics of the mutant and the WT forms of the EGF. RMSD analysis showed that WT EGF was more stable than the mutant structures. The docking analysis revealed that the binding energy of mutant EGFs to EGFR is lower than WT. Combination of the used computational approaches provides a way in understanding the impact of deleterious mutations in altering the EGF and EGFR interactions.
TESS Experiments: How Social Class and the Framing of Income Inequality Affect Solidarity Within & Across Groups
Creators: name: Craig, Maureen
name: Dietze, Pia
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Time-sharing Experiments for the Social Sciences (TESS) offers researchers the opportunity to capture the internal validity of experiments. Investigators submit proposals, and TESS fields successful proposals for free on a representative sample of adults in the United States. This experiment was conducted to examine how framing and social class influence support for collective action against inequality among Americans who self-identify as lower class (poor or working class) or upper class (upper-middle class or upper class). The total 1,816 respondents were assigned randomly to read an infographic highlighting economic inequality either in terms of lower-class disadvantage or upper-class privilege. Respondents were then asked a series of questions on perceived solidarity between the lower class and minorities, whether they would support policies aimed at alleviating economic inequalities, and willingness to take collective action. This allowed for investigation of possible mediators of the effect of framing on reparative or collective action tendencies and whether individuals endorse redistributive policies and collective action for class related issues alone or for policies regarding other social inequalities (for similarly stigmatized groups, such as Black Americans, or stigmatized groups more broadly, including transgender Americans).
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.12.1953, erstellt von Edibe Balli-Tüzemen an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.10.1953, erstellt von Wolfgang Gleissberg an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Lysine Succinylation of Mycobacterium tuberculosis Isocitrate Lyase (ICL) fine-tunes the Microbial Resistance to Antibiotics
Creators: name: Mingliang Zhou
name: Longxiang Xie
name: Zhaozhen Yang
name: Jiahai Zhou
name: Jianping Xie
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Lysine succinylation (Ksucc) is a newly identified protein posttranslational modification (PTM), which plays important role in cellular physiology and pathogenesis. However, the role of lysine succinylation in antibiotic resistance remains elusive. Isocitrate lyase (ICL) is crucial for broad-spectrum antibiotics tolerance in Mycobacterium tuberculosis (Mtb). We previously found that MtbICL (Rv0467) has at least three succinylated lysine residues, namely K189, K322, and K334.To explore the effect of succinylation on the activity of MtbICL, mutants mimicry of the lysine succinylation were generated by site-directed mutagenesis. ICL-K189E mutant strain is more sensitive to rifampicin and streptomycin, but not isoniazid, than the wild type. For the in vitro activity of the purified isocitrate lyase, only K189E mutant showed significantly decreased activity. Crystal structure analysis showed that Lys189 Glu dramatically increased the pKa of Glu188 and decreased the pKa of Lys190, whereas had negligible effect on other residues within 5 Å as well as disruption of the electrostatic interaction between Lys189 and Glu182, which might prevent the closure of the active site loop and cause severe reduction of the enzyme activity. Taken the genetic, biochemical and crystallographical evidences together, the succinylation of specific ICL residue can fine-tune the bacterial resistance to selected antibiotics. The decreased enzymatic activity resulting from the succinylation changed electrostatic interaction might underlie this phenotype. This study provided the first insight into the link between lysine succinylation and antibiotic resistance.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.11.1953, erstellt von Paul Bourgeois, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung auf eigener, gedruckter Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
TESS Experiments: Behavioral Reactions to Skin Infections: Informing Agent-Based Modeling of the MRSA Epidemic - Wave 2
Creators: name: Wegener, Duane
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Time-sharing Experiments for the Social Sciences (TESS) offers researchers the opportunity to capture the internal validity of experiments. Investigators submit proposals, and TESS fields successful proposals for free on a representative sample of adults in the United States. This experiment was conducted to examine the influence of public health recommendations on the public’s actions to reduce the spread of Methicillin-resistant Staphylococcus aureus (MRSA) infections. In the first wave, respondents were randomly assigned to one of four conditions which varied by wound type (draining or non-draining) and public health messaging (Centers for Disease Control and Prevention (CDC) recommendations to cover the wound and seek medical attention presented or not). A total of 1,980 respondents participated in the first wave. First wave respondents were surveyed on previous experience and knowledge of MRSAs, perceived susceptibility and risk, and likelihood of seeking medical care. The second wave was a 6-month follow-up study to test if respondents had retained information from the messaging (n=1379). Respondents in the follow-up survey were shown the basic sore description presented in wave one and asked if they had had a similar sore in the previous 6 months, whether they sought medical attention, and how likely they would be to seek medical care for a painful skin sore. This allowed for comparison of processing of public health messaging and message retention, as well as MRSA base knowledge, across core demographic variables.
TESS Experiments: A Piece of the Pie: Achievement, Children's Sex, and Parent Resource Distribution
Creators: name: Yurk, Natasha
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Time-sharing Experiments for the Social Sciences (TESS) offers researchers the opportunity to capture the internal validity of experiments. Investigators submit proposals, and TESS fields successful proposals for free on a representative sample of adults in the United States. This experiment was conducted to explore perceptions of family resource distributions based on children’s achievement and gender. Respondents were randomly assigned to one of fifteen vignettes in which a hypothetical set of parents received feedback from their children’s teachers suggesting that their two children are in need of more resources to improve their academic performance. Vignettes varied the academic achievement pairing (high-high, average-average, low-low, high-average, high-low, average-low) and gender pairs (boy and girl, two girls, or two boys). A total of 3,490 respondents participated. After reading the vignettes, respondents answered questions about how the parents should allocate time and financial resources between the two children. This allowed for comparison of allocations based on child sex, achievement, and interaction effects between the two.
Sonnenfleckenzeichnung Nr. 18547.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.10.1953, erstellt von Adolf Lemans
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
TESS Experiments: Body Size, Illness, and Blame: Causal Attributions and Social Consequences
Creators: name: Powroznik, Karen
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Time-sharing Experiments for the Social Sciences (TESS) offers researchers the opportunity to capture the internal validity of experiments. Investigators submit proposals, and TESS fields successful proposals for free on a representative sample of adults in the United States. This experiment was conducted to explore how a patient’s body size, gender, and race influence beliefs about the cause of medical conditions. The total 1,387 respondents were randomly assigned to read one of two disease profiles (type II diabetes or non-Hodgkin lymphoma) and then to read the profile of a patient with that disease. Patient profiles varied by gender (male or female), race (African American or White), and body size (moderately obese or normal weight). Respondents were asked to attribute the cause of the disease to lifestyle, environment, genetics, and/or bad luck and indicate whether they believe the patient responsible and to blame for becoming ill. Respondents also answered measures of sympathy for, willingness to help, social distance from, and willingness to penalize the patient. This allowed for comparison of responses across patient and disease characteristics.
Sonnenfleckenzeichnung Nr. 18518.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.08.1953, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.12.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Investigation of the early stages of human γD-crystallin aggregation process
Creators: name: Chih-Kai Chang
name: Wang, Steven S.-S.
name: Chun-Hsien Lo
name: Hsiang-Chun Hsiao
name: Wu, Josephine W.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Cataract, a major cause of visual impairment worldwide, is a common disease of the eye lens related to protein aggregation. Several factors including the exposure of ultraviolet irradiation and possibly acidic condition may induce the unfolding and subsequent aggregation of the crystallin proteins leading to crystalline lens opacification. Human γD-crystallin (HγDC), a 173 residue monomeric protein, abundant in the nucleus of the human eye lens, has been shown to aggregate and form amyloid fibrils under acidic conditions and that this aggregation route is thought to be a potential initiation pathway for the onset of age-related nuclear cataract. However, the underlying mechanism of fibril formation remains elusive. This report is aimed at examining the structural changes and possible amyloid fibril formation pathway of HγDC using molecular dynamics and molecular docking simulations. Our findings demonstrated that incubation of HγDC under the acidic condition redistributes the protein surface charges and affects the protein interaction with its surrounding solvent environment. This brings about a twist motion in the overall tertiary structure that gives rise to newly formed anti-parallel β-strands in the C-terminal flexible loop regions. The change in protein structural conformation also involves an alteration in specific salt-bridge interactions. Altogether, these findings revealed a plausible mechanism for amyloid fibril formation of HγDC that is important to the early stages of HγDC aggregation involved in cataractogenesis.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.09.1953, erstellt von Ludmilla Pajdusakova am Skalnate Pleso Observatorium.
(Formularaufdruck lautend auf Slovensky ustredny ustav astronomicky Tatranska Lomnica)
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Observatorium Skalnate Pleso bei Tatranska Lomnica. Slovensky ustredny ustav astronomicky Tatranska Lomnica (Slowakisches Zentralinstitut).  Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.12.1953, erstellt von J. Delange, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung auf eigener, gedruckter Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.09.1953, erstellt von Ludmilla Pajdusakova am Skalnate Pleso Observatorium.
(Formularaufdruck lautend auf Slovensky ustredny ustav astronomicky Tatranska Lomnica)
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Observatorium Skalnate Pleso bei Tatranska Lomnica. Slovensky ustredny ustav astronomicky Tatranska Lomnica (Slowakisches Zentralinstitut).  Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.11.1953, erstellt von Paul Bourgeois, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung auf eigener, gedruckter Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Effects of osmolytes on solvent features of water in aqueous solutions
Creators: name: Ferreira, Luisa A.
name: Breydo, Leonid
name: Reichardt, Christian
name: Uversky, Vladimir N.
name: Zaslavsky, Boris Y.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology
subject: 60506 Virology

description: The solvatochromic solvent features of water (dipolarity/polarizability, π*, hydrogen bond donor acidity, α, and hydrogen bond acceptor basicity, β) of water have been determined in aqueous solutions of erythritol, glucose, inositol, sarcosine, xylitol and urea with concentrations from 0 to ~3 M and higher. The concentration effects of the osmolytes on the solvent features of water were characterized and compared with those reported previously for sorbitol, sucrose, trimethylamine N-oxide (TMAO), and trehalose. The solvent features of water in solutions of all osmolytes except TMAO and sarcosine were established to be linearly interrelated. It is shown that the concentration effects of essentially all nonionic osmolytes depend on osmolytes’ lipophilicity, molecular polarizability, and polar surface area. It is demonstrated that solubility of various compounds in aqueous solutions of glucose, sucrose, sorbitol, and urea of varied concentrations may be described in terms of solvent dipolarity/polarizability of water in these solutions. Surface tension of aqueous solutions of sucrose and sorbitol may also be described in the same terms. The relative permittivity of aqueous solutions of glucose and sucrose may be described in terms of the solvent hydrogen bond donor acidity of water. It is suggested that the effects of nonionic osmolytes on behavior of proteins and nucleic acids in aqueous media may be considered in terms of the altered solvent features of water instead of “nano-molecular crowding” effect.
Identifying patterns of alumni commitment in key strategic relationship programmes
Creators: name: Pedro, Ilda
name: Mendes, Júlio Da Costa
name: Pereira, Luis Nobre
Publisher: name: ICAReAlumni Conference Proceedings
Year: 2022

description: Presentation whose subject objectives are: Objective 1. To characterize the alumni commitment. Objective 2. To describe overall patterns in alumni commitment.
description: ICAReAlumni Conference Proceedings, No. 4 (2022): Proceedings of the VI ICAReAlumni Conference
How to turn POTEntial Alumni into Alumni with POTEntial
Creators: name: Somodi, Klára
name: Abada, Alan
Publisher: name: ICAReAlumni Conference Proceedings
Year: 2022

description: The aim of this paper is to present the collaborative approach the Alumni Team of the University of Pécs Medical School (UPMS) initiated, piloted, and carried out in two consecutive semesters. This approach, the Junior Alumni Program (JAP), aims to equip students with the soft skills and career guidance needed to excel during their educational journey and beyond. The program offers workshops and resources which were intentionally designed to complement the traditional curriculum. By harnessing the experience and expertise of successful alumni, students gain exclusive access to knowledge and opportunities through the extensive POTE (POTE is the Hungarian abbreviation of the Medical University of Pécs) network. As a bonus, ‘regular’ Alumni involvement is growing exponentially through Junior Alumni events. The Alumni Team is dedicated to turn POTEntial Alumni into Alumni with POTEntial.
description: ICAReAlumni Conference Proceedings, No. 4 (2022): Proceedings of the VI ICAReAlumni Conference
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.09.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Understanding alumni loyalty from a relational marketing approach
Creators: name: Martinez-Hagu, Paloma
name: Lau, Milos
name: Macarachvili, Andres
Publisher: name: ICAReAlumni Conference Proceedings
Year: 2022

description: Iskhakova, Hoffmann and Hilbert (2017) identify the benefits of a close university-Alumni relationship. On the one hand, material benefits are donations or financial contributions and repurchase behavior based on the lifelong learning theory. On the other hand, non-material benefits are levels of commitment and loyalty of Alumni towards the university. Some of these benefits are: (a) the professional profile of the university's graduates for the accreditation processes, (b) the positioning of the university in the labor market, (c) the direct connection with organizations, and (d) voluntary participation in aspects such as teaching, mentoring and tutoring that provide a better learning experience for students (Hummel, 2010; López & Jaramillo, 2020). It is safe to recognize Alumni as one of the university's main stakeholders. That is why managing the relationship and communication with them is critical. Faced with this need, many educational institutions use relationship marketing to resolve it. Relationship marketing is the creation of a strategy that seeks to attract and retain relationships with the main stakeholders (Mallada & Colom, 2010; Palacio & Rondón, 2018; Schlesinger, Cervera & Iniesta, 2012). This article seeks to understand the university-Alumni relationship by applying the Alumni-University Identification Model proposed by Schlesinger, Cervera, Iniesta & Sánchez (2014) and Schlesinger et al. (2012). This model is based on relationship marketing and seeks to understand the quality of interactions between the university and its Alumni. In the same way, the level of identification Alumni has with their alma mater. Furthermore, how this affects their commitment and loyalty to the university. The case study is in the Pontificia Universidad Católica del Perú (PUCP university) and Alumni from its School of Management. This research will use a quantitative approach to seek to test the hypotheses of the relationship between factors raised by Schlesinger et al. (2014). The estimation of the relationships will be done under the structural equation model using the partial least squares regression method. The information collected to meet the research objectives will be through a questionnaire based on Schlesinger et al. (2014), whose constructs present high levels of reliability, aimed at students who graduated between the periods 2010 - 2019 from the School of Management of the PUCP.
description: ICAReAlumni Conference Proceedings, No. 4 (2022): Proceedings of the VI ICAReAlumni Conference
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.08.1953, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.09.1953, erstellt von J. Delange, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1953

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung auf eigener, gedruckter Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)