cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Eurasian Economic Union: A Brittle Road Block on China's "One Belt – One Road" - A Liberal Perspective
Creators: name: Zank, Wolfgang
Publisher: name: Journal of China and International Relations
Year: 2017

description: In this article, I explore the development and character of the Eurasian Economic Union (EEU) and its compatibility with China's OBOR initiative. The genesis of the EEU is placed in the context of Russia's attempts to fill its "Monroe Doctrine" with substance, i.e. to claim the post-Soviet space as a zone of exclusive Russian influence. Russia's "Monroe Doctrine" was primarily formulated against the EU, its enlargement and its "European Neighbourhood Policy" (ENP) which offers privileged relations also to countries in the post-Soviet space. The logic of the Russian "Monroe Doctrine" works, however, against all countries trying to establish closer ties with former Soviet republics, China included. In 2013, President Putin presented the EEU as a predominantly political project, shortly after the Chinese President had launched the OBOR initiative; all twelve states in the post-Soviet space were invited to participate. However, Georgia, Moldova and Ukraine opted for an association agreement with the EU, a move to which Russia responded by the annexation of Crimea and starting an insurgency in Eastern Ukraine. In 2015, the EEU officially started with the participation of only five countries: Armenia, Belarus, Kazakhstan, Kyrgyzstan and Russia. It implied the extension of the rather high Russian tariffs to the whole EEU, a move which had negative effects on Chinese transactions with the region. This, however, could not impede a rise of the Chinese presence in Central Asia. In its present form, the EEU is not compatible with the OBOR initiative. A free-trade agreement between China and the EEU could make it compatible, but this is not a realistic perspective for the near future. The EEU seems to be an unstable construction, with many basic rules and norms being unclear, and many tensions and conflicts among its members.
description: Journal of China and International Relations, Vol 5 No 1 (2017)
title: Economic and workload impact of sars cov2 infection in department of diagnostic imaging
Creators: name: cristofaro, massimo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Management
subject: PACS
subject: Health policy and practice
subject: Economics

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The COVID-19 pandemic caused an unprecedented effect on national radiologicalinvestigations. The aim of this work is to evaluate the economic impact on Radiology Department of an infectious disease...
Möbius disjointness for homogeneous dynamics
Creators: name: Peckner, Ryan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 11N37, 22D40, 37C40, 22F30, 22E40, 22E46

description: We prove Sarnak's Möbius disjointness conjecture for all unipotent translations on homogeneous spaces of real connected Lie groups. Namely, we show that if $G$ is any such group, $Γ\subset G$ a lattice, and $u\in G$ an Ad-unipotent element, then for every $x\inΓ\backslash G$ and every continuous, bounded function $f$ on $Γ\backslash G$, the sequence $f(xu^{n})$ cannot correlate with the Möbius function on average.
description: 35 pages, proof of proposition 3.10 contained an error that has been corrected
ESTDIO PROSPECTIVO DE 3 CASOS CLINICOS MANEJADOS CON DISCUS COMPOSITUM, CARTILAGO SUIS Y TRAUMEEL EN PACIENTES DE FISIOTERPIA Y REHABILITACIÓN
Creators: name: BOLIVAR BARACALDO, NANCY
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 300907
subject: Veterinary medicine (excl. urology)
classificationCode: 300999
subject: Veterinary sciences not elsewhere classified
classificationCode: 300911
subject: Veterinary pharmacology

description: En este estudio mostramos la aplicación del Discus compositum, cartílago suis y traumeel en tres pacientes con lesión medular con poca posibilidad de recuperar su movilidad, se aplicaron estos medicamentos en puntos de acupuntura que están indicados en osteocondrosis, enfermedades neurálgico reumáticas (de la columna vertebral) artritis crónica y otros diagnósticos. Se estudiaron 3 pacientes que consultaron en la clínica veterinaria Biopet. Vet entre el 2022-2023 por presentar trauma medular con pronóstico de eutanasia. Se realizó fisioterapia rehabilitación integrativa y acupuntura donde se busca sanar y recuperar al máximo todas las capacidades motrices de nuestros pacientes que han sido afectados por una lesión o enfermedad.La duración y evolución del tratamiento oscilo entre las dos semanas y siete meses, aunque cabe resaltar que uno de los pacientes mostro mejoría a las dos semanas de tratamiento; el segundo paciente a los cuatro meses y el tercero a los siete meses mostrando una buena evolución Se evidenció la eficacia del tratamiento en estos pacientes y la tolerabilidad del medicamento fue positiva.El tratamiento convencional de estas patologías se basa en el uso de AINE’s , corticoides, opioides. Donde también se logro reducir el uso de estos medicamentos alopáticos.Se decidió realizar un abordaje con medicina biorreguladora utilizando medicamentos Discus compositum, Cartílago suis injeel y Traumeel donde se dio un enfoque individual e integral a cada paciente observando una rápida evolución sin ninguna alteración o efectos adversos y mejorando su calidad de vida.Los pacientes tratados habían tenido un pronóstico desfavorable en las anteriores clínicas en las que habían sido tratados por los cual estaban a punto de realizarles el procedimiento de la eutanasia
title: 3D Printing: An extension of conventional radiology in interventional medicine
Creators: name: Constantinescu, Andrei Stefan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Arteries / Aorta
subject: Interventional vascular
subject: CT
subject: CT-Angiography
subject: Angioplasty
subject: Stents
subject: Aneurysms
subject: Arteriosclerosis
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: 3D printing represents an efficient solution for the design and manufacture of medical interventional simulators. 3D printed interventional planning ( simulating an endovascular procedure of a 3d printed model before the real procedure) allows...
The Gillings Sampler – An electrostatic air sampler as an alternative method for aerosol in vitro exposure studies
Creators: name: Zavala, Jose
name: Jeffries, Harvey E.
name: Vizuete, William
name: Carson, Johnny L.
name: Sexton, Kenneth G.
name: Lichtveld, Kim
name: Walters, Glenn W.
name: Jaspers, Ilona
name: Ebersviller, Seth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: There is growing interest in studying the toxicity and health risk of exposure to multi-pollutant mixtures found in ambient air, and the U.S. Environmental Protection Agency (EPA) is moving towards setting standards for these types of mixtures. Additionally, the Health Effects Institute's strategic plan aims to develop and apply next-generation multi-pollutant approaches to understanding the health effects of air pollutants. There's increasing concern that conventional in vitro exposure methods are not adequate to meet EPA's strategic plan to demonstrate a direct link between air pollution and health effects. To meet the demand for new in vitro technology that better represents direct air-to-cell inhalation exposures, a new system that exposes cells at the air-liquid interface was developed. This new system, named the Gillings Sampler, is a modified two-stage electrostatic precipitator that provides a viable environment for cultured cells. Polystyrene latex spheres were used to determine deposition efficiencies (38-45%), while microscopy and imaging techniques were used to confirm uniform particle deposition. Negative control A549 cell exposures indicated the sampler can be operated for up to 4 hours without inducing any significant toxic effects on cells, as measured by lactate dehydrogenase (LDH) and interleukin-8 (IL-8). A novel positive aerosol control exposure method, consisting of a p-tolualdehyde (TOLALD) impregnated mineral oil aerosol (MOA), was developed to test this system. Exposures to the toxic MOA at a 1 ng/cm2 dose of TOLALD yielded a reproducible 1.4 and 2 fold increase in LDH and IL-8 mRNA levels over controls. This new system is intended to be used as an alternative research tool for aerosol in vitro exposure studies. While further testing and optimization is still required to produce a “commercially ready” system, it serves as a stepping-stone in the development of cost-effective in vitro technology that can be made accessible to researchers in the near future.
Event Driven Tactile Sensors for Artificial Devices
Creators: name: ABOU KHALIL, ALI
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Present-day robots are, to some extent, able to deal with high complexity and variability of the real-world environment. Their cognitive capabilities can be further enhanced, if they physically interact and explore the real-world objects. For this, the need for efficient tactile sensors is growing day after day in such a way are becoming more and more part of daily life devices especially in robotic applications for manipulation and safe interaction with the environment. In this thesis, we highlight the importance of touch sensing in humans and robots. Inspired by the biological systems, in the the first part, we merge between neuromorphic engineering and CMOS technology where the former is a eld of science that replicates what is biologically (neurons of the nervous system) inside humans into the circuit level. We explain the operation and then characterize different sensor circuits through simulation and experiment to propose finally new prototypes based on the achieved results. In the second part, we present a machine learning technique for detecting the direction and orientation of a sliding tip over a complete skin patch of the iCub robot. Through learning and online testing, the algorithm classies different trajectories across the skin patch. Through this part, we show the results of the considered algorithm with a future perspective to extend the work.
title: A CT review of congenital lung malformations in pediatric age group.
Creators: name: Sherene, Haleema
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiovascular system
subject: Lung
subject: Paediatric
subject: CT
subject: CT-Angiography
subject: CT-High Resolution
subject: Contrast agent-intravenous
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the CECT and HRCT thorax done in the pediatric age group up to 12 years of age, reported in the last 10 years in our institution. To demonstrate the usefulness of CT scans to confirm the diagnosis and to determine the extent of the lesion...
title: II. Noun Group problems I – Probleme der Nominalgruppe I
title: Linguistic research in progress (Part II, Summer Semester 1992)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
ENDOTHELIAL SIRT6 BLUNTS STROKE SIZE AND NEUROLOGICAL DEFICIT BY PRESERVING BLOOD-BRAIN BARRIER INTEGRITY: A TRANSLATIONAL STUDY
Creators: name: LIBERALE, LUCA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Aims: Aging is an established risk factor for stroke; genes regulating longevity are implicated in the pathogenesis of ischaemic stroke where to date, therapeutic options remain limited. The blood-brain barrier (BBB) is crucially involved in ischaemia/reperfusion (I/R) brain injury thus representing an attractive target for developing novel therapeutic agents. Given the role of endothelial cells in the BBB, we hypothesized that the endothelial-specific expression of the recently described longevity gene SIRT6 may exhibit protective properties in stroke. Methods and results: SIRT6 endothelial expression was reduced following stroke. Endothelial-specific Sirt6 knockout (eSirt6-/-) mice, as well as animals in which Sirt6 overexpression was post-ischaemically induced, underwent transient middle cerebral artery occlusion (tMCAO). eSirt6-/- animals displayed increased infarct volumes, mortality, and neurological deficit after tMCAO, as compared to control littermates. Conversely, post-ischaemic Sirt6 overexpression decreased infarct size and neurological deficit. Analysis of ischaemic brain sections revealed increased BBB damage and endothelial expression of cleaved caspase-3 in eSIRT6-/- mice as compared to controls. In primary human brain microvascular endothelial cells (HBMVECs), hypoxia/reoxygenation (H/R) reduced SIRT6 expression and SIRT6 silencing impaired the barrier function (transendothelial resistance) similar to what was observed in mice exposed to I/R. Further, SIRT6-silenced HBMVECs exposed to H/R showed reduced viability, increased cleaved caspase-3 expression and reduced activation of the survival pathway Akt. In ischaemic stroke patients, SIRT6 expression was higher in those with short-term neurological improvement as assessed by NIHSS scale and correlated with stroke outcome. Conclusion: Endothelial SIRT6 exerts a protective role in ischaemic stroke by blunting I/R-mediated BBB damage and thus, it may represent an interesting novel therapeutic target to be explored in future clinical investigation.
title: Simple phantom for the Quality Assurance of Quantitative MRI
Creators: name: Semenov, Dmitry
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: MR physics
subject: MR
subject: MR-Diffusion/Perfusion
subject: Equipment
subject: Technical aspects
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Quantitative Magnetic Resonance Imaging (qMRI) is a developed technology that has the perspective of using regarding on the personalized healthcare practice. However, it is necessary to provide the accuracy and precision for these measurements, as...
title: VI. Relative clauses I – Relativsätze I
title: Linguistic research in progress (Part VI, Summer Semester 1995)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: See the Editor's Summary introducing this Part.
Using an Enzymatic Combinatorial Approach to Identify Anticoagulant Heparan Sulfate Structures
Creators: name: Liu, Jian
name: Chen, Jinghua
name: Jones, Courtney L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Heparan sulfate (HS) represents a major class of glycans that perform central physiological functions. Emerging HS and glycosaminoglycan microarray techniques are used to interrogate the structure and function relationship to develop novel therapeutic agents. Availability of HS with specific sulfation patterns has been a limiting factor, and impedes the accuracy of HS glycomics studies. Although organic synthesis provides oligosaccharides, these may not fully represent the biological functions of polysaccharides. Here, we present a study for developing an enzyme-based approach to synthesize a polysaccharide library with different sulfation patterns. Using different combinations of biosynthetic enzymes, we synthesized eight unique polysaccharides. We discovered that polysaccharides without iduronic acid residue displayed strong binding affinity to antithrombin and high anti-Xa and anti-IIa activities. The enzyme-based synthetic approach could become a general method for discovering new HS structures with unique biological functions.
Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis
Creators: name: Provencher, Laurel M.
name: Brown, Peter J.
name: Wigle, Tim J.
name: Norris, Jacqueline L.
name: Janzen, William P.
name: Jin, Jian
name: Frye, Stephen V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The discovery of small molecules targeting the > 80 enzymes that add (methyltransferases) or remove (demethylases) methyl marks from lysine and arginine residues, most notably present in histone tails, may yield unprecedented chemotherapeutic agents and facilitate regenerative medicine. To better enable chemical exploration of these proteins, we have developed a novel and highly quantitative microfluidic capillary electrophoresis assay to enable full mechanistic studies of these enzymes and the kinetics of their inhibition. This technology separates small biomolecules, i.e., peptides, based on their charge-to-mass ratio. Methylation, however, does not alter the charge of peptide substrates. To overcome this limitation, we have employed a methylation-sensitive endoproteinase strategy to separate methylated from unmethylated peptides. The assay was validated on a lysine methyltransferase (G9a) and a lysine demethylase (LSD1) and was employed to investigate the inhibition of G9a by small molecules.
Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design
Creators: name: Nicholas, Robert A.
name: Liang, Xiaofei
name: Li, Yaoxian
name: Barb, Adam W.
name: Toone, Eric J.
name: Swanson, Shauna M.
name: Zeng, Daina
name: Raetz, Christian R.H.
name: Chung, Hak Suk
name: Chen, Xin
name: Lee, Chul Jin
name: Zhou, Pei
name: Joo, Sang Hoon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: LpxC is an essential enzyme in the lipid A biosynthetic pathway in Gram-negative bacteria. Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typically display a large variation in potency against different Gram-negative pathogens. We report that inhibitors with a diacetylene scaffold effectively overcome the resistance caused by sequence variation in the LpxC substrate-binding passage. Compound binding is captured in complex with representative LpxC orthologs, and structural analysis reveals large conformational differences that mostly reflect inherent molecular features of distinct LpxC orthologs, whereas ligand-induced structural adaptations occur at a smaller scale. These observations highlight the need for a molecular understanding of inherent structural features and conformational plasticity of LpxC enzymes for optimizing LpxC inhibitors as broad-spectrum antibiotics against Gram-negative infections.
title: Laryngeal cancer: thinking outside the box
Creators: name: Arain, Zoya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: CT
subject: MR
subject: Ultrasound
subject: Staging
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Radiological staging of laryngeal cancer directly influences surgical and oncological treatment. This presentation will review the important anatomy, patterns of tumour infiltration, applying a multimodality approach and pitfalls in evaluation of...
Point-of-care diagnostics for Single Nucleotide Polymorphisms genotyping: applications to food traceability, nutrigenetics and pharmacogenetics
Creators: name: CIBECCHINI, GIULIA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Single Nucleotide Polymorphisms (SNPs) are common genetic variations associated to specific phenotypes. SNPs have high relevance in different biomedical areas including both preventive/personalized medicine and non-clinical contexts, such food traceability. However, current techniques for SNP genotyping are expensive, require specialized laboratories and costly instrumentations, and are time consuming. In this framework, the development of rapid, point-of-care (POC) SNP diagnostic technologies would be of great interest, opening new possibilities for early, on-site screenings in multiple fields. In this PhD thesis, starting from state-of-art approaches, a rapid and portable diagnostic strategy based on Loop Mediated Isothermal Amplification (LAMP) has been developed for SNPs genotyping. In particular, the developed strategy was applied and validated, in a naked-eye colorimetric approach, for food varietal discrimination (i.e. durum wheat variety) in a model case of industrial relevance. Moreover, the POC technology was targeted to different salivary biomarkers, to address nutrigenetics and pharmacogenetics issues. Notably, the possibility to rapidly diagnose the genetic predisposition to lactose intolerance or the impairment of folic acid metabolism was proven. Furthermore, the developed POC-compatible protocols can work with portable, battery-powered devices, allowing for POC operation of such diagnostic tests.
Designing Photoswitchable Peptides Using the AsLOV2 Domain
Creators: name: Choi, Eun Jung
name: Lungu, Oana I.
name: Aiken, Mary J.
name: Hallett, Ryan A.
name: Kuhlman, Brian
name: Hahn, Klaus M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Photocontrol of functional peptides is a powerful tool for spatial and temporal control of cell signaling events. We show that the genetically encoded light-sensitive LOV2 domain of Avena Sativa phototropin 1 (AsLOV2) can be used to reversibly photomodulate the affinity of peptides for their binding partners. Sequence analysis and molecular modeling were used to embed two peptides into the Ja helix of the AsLOV2 domain while maintaining AsLOV2 structure in the dark, but allowing for binding to effector proteins when the Jα helix unfolds in the light. Caged versions of the ipaA and SsrA peptides, LOV-ipaA and LOV-SsrA, bind their targets with 49-fold and 8-fold enhanced affinity in the light, respectively. These switches can be used as general tools for light dependent co-localization, which we demonstrate with photoactivable gene transcription in yeast.
title: Altered nodal efficiency by Type 2 Diabetes Mellitus: A resting-state fMRI study
Creators: name: Du, Wei
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: MR
subject: MR-Functional imaging
subject: Experimental investigations
subject: Metabolic disorders

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: This study aimed to investigate the nodal efficiency changes of functional networks in patients with...
Le regole parlamentari tra diritto e politica. Un equilibrio precario
Creators: name: FUCCARO, NICOLO'
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Le evoluzioni del sistema politico italiano e del funzionamento della forma di governo, condizionate dalle modifiche della legislazione elettorale e dei Regolamenti delle Camere, incidono profondamente sulle dinamiche interne delle due Assemblee e sull'approccio interpretativo e applicativo delle regole parlamentari che vengono adattate al contesto in cui vivono. Attraverso un approccio diacronico che tenga conto della relazione tra i mutamenti dell?assetto politico-istituzionale e le prassi instauratesi all'interno delle Aule, il presente studio analizza ad ampio spettro alcuni significativi istituti e procedure del diritto parlamentare italiano, distinti per funzione, muovendo dall'inquadramento dei suoi peculiari caratteri e dalle sue fonti. In tal modo ci si propone di verificare come e in quale misura le regole parlamentari sono applicate o disapplicate, interpretate, integrate, derogate e talvolta apertamente violate, cedendo il passo alle ragioni e alle contingenti esigenze della politica e del processo politico-parlamentare e mettendo in tensione i principi costituzionali che presiedono all'esercizio delle funzioni attribuite alle Camere.
A Low-Rank Coordinate-Descent Algorithm for Semidefinite Programming Relaxations of Optimal Power Flow
Creators: name: Marecek, Jakub
name: Takac, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: The alternating-current optimal power flow (ACOPF) is one of the best known non-convex non-linear optimisation problems. We present a novel re-formulation of ACOPF, which is based on lifting the rectangular power-voltage rank-constrained formulation, and makes it possible to derive alternative SDP relaxations. For those, we develop a first-order method based on the parallel coordinate descent with a novel closed-form step based on roots of cubic polynomials.
(401420) Samuel Hendrick Barclay
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Fat necrosis of breast or recurrence? Typical and atypical aspects
Creators: name: Zerouali, Zineb
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Biopsy
subject: Trauma

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Objectives: To present the different aspects of cytosteatonecrosis in conventional imaging: mammography and ultrasound. Specify the role of MRI in the event of atypical...
INGLIZ VA O'ZBEK TILLARIDA QO'SHMA SO'ZLARNING SEMANTIK XUSUSIYATLARI
Creators: name: Bakirova, Gulasal
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada Ingliz va o'zbek tillarida qo'shma so'zlarning semantik xususiyatlari, qo'shma so'zlar klassifikatsiyasi, Qo'shma so'zlarning endosentrik va ekzosentrik tomonlari haqida ma'lumotlar berilgan.
Two-dimensional quantum walk under artificial magnetic field
Creators: name: Yalçınkaya, İ.
name: Gedik, Z.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce the Peierls substitution to a two-dimensional discrete-time quantum walk on a square lattice to examine the spreading dynamics and the coin-position entanglement in the presence of an artificial gauge field. We use the ratio of the magnetic flux through the unit cell to the flux quantum as a control parameter. For a given flux ratio, we obtain faster spreading for a small number of steps and the walker tends to be highly localized around the origin. Moreover, the spreading of the walk can be suppressed and decreased within a limited time interval for specific rational values of flux ratio. When the flux ratio is an irrational number, even for a large number of steps, the spreading exhibit diffusive behavior rather than the well-known ballistic one as in the classical random walk and there is a significant probability of finding the walker at the origin. We also analyze the coin-position entanglement and show that the asymptotic behavior vanishes when the flux ratio is different from zero and the coin-position entanglement become nearly maximal in a periodic manner in a long time range.
description: 7 pages, 5 figures, sections 3 and 4 revised
(401421) Alexander Barclay
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies
Creators: name: Zacharko, Melody A.
name: Ellington, Andrew D.
name: Gray, Jeffrey J.
name: Carney, James P.
name: Kuhlman, Brian
name: Der, Bryan S.
name: Georgiou, George
name: Sircar, Aroop
name: Kluwe, Christien
name: Calm, Alena M.
name: Pai, Supriya
name: Xu, Jianqing
name: Welsh, Heather S.
name: Warner, Candice R.
name: Buckley, Patricia E.
name: Berrondo, Monica
name: Miklos, Aleksandr E.
name: Codrea, Vlad
name: Hughes, Randall A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Mutation of surface residues to charged amino acids increases resistance to aggregation and can enable reversible unfolding. We have developed a protocol using the Rosetta computational design package that “supercharges” proteins while considering the energetic implications of each mutation. Using a homology model, a single-chain variable fragment antibody was designed that has a markedly enhanced resistance to thermal inactivation and displays an unanticipated ≈30-fold improvement in affinity. Such supercharged antibodies should prove useful for assays in resource-limited settings and for developing reagents with improved shelf lives.
Additional file 1 of Application of OU processes to modelling temporal dynamics of the human microbiome, and calculating optimal sampling schemes
Creators: name: Kenney, Toby
name: Junqiu Gao
name: Gu, Hong
Publisher: name: figshare
Year: 2020
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1: Supplemental Appendices.
Chemoproteomic Discovery of AADACL1 as a Regulator of Human Platelet Activation
Creators: name: Holly, Stephen P.
name: Parise, Leslie V.
name: Boulaftali, Yacine
name: Phillips, Ryan M.
name: Li, Weiwei
name: Smith, Matthew C.
name: Chang, Jae Won
name: Black, Justin L.
name: Weyrich, Andrew S.
name: Niessen, Sherry
name: Bergmeier, Wolfgang
name: Cravatt, Benjamin F.
name: Piatt, Raymond
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A comprehensive knowledge of the platelet proteome is necessary for understanding thrombosis and for conceiving novel antiplatelet therapies. To discover new biochemical pathways in human platelets, we screened platelets with a carbamate library designed to interrogate the serine hydrolase subproteome and used competitive activity-based protein profiling to map the targets of active carbamates. We identified an inhibitor that targets arylacetamide deacetylase-like 1 (AADACL1), a lipid deacetylase originally identified in invasive cancers. Using this compound, along with highly selective second-generation inhibitors of AADACL1, metabolomics and RNA interference, we show that AADACL1 regulates platelet aggregation, thrombus growth, RAP1 and PKC activation, lipid metabolism and fibrinogen binding to platelets and megakaryocytes. These data provide the first evidence that AADACL1 regulates platelet and megakaryocyte activation and highlight the value of this chemoproteomic strategy for target discovery in platelets.
The "Asia-Pacific Dream": Is China Using Economic Integration Initiatives as Ideological Weapons? – On The Link Between Free Trade Agreements, Soft Power and "Universal Values"
Creators: name: Berndzen, Anke
Publisher: name: Journal of China and International Relations
Year: 2017

description: This article examines the function and role of the "Asia-Pacific Dream" (including the FTAAP) in China's foreign policy strategy by analysing the speech in which Xi Jinping promoted this dream, and creating a link between China's push for regional economic integration, soft power strategy and "universal values". While China is promoting this concept and the FTAAP to increase its influence in the region, the U.S. have also been rebalancing to Asia through different means, such as its push for the TPP. These two free trade agreements (FTA), though not mutually exclusive, are considered to be directed against each other, indicating a struggle for influence in the region, and also seem to entail an ideological agenda. As both the "Asia-Pacific Dream" and the U.S. "pivot to Asia" are connected to major FTA's, this paper argues that the motives for promoting these FTAs go far beyond economic interests; the research suggests that they are used to increase soft power in the region as well as to influence the discourse on "universal values".
description: Journal of China and International Relations, Vol 5 No 1 (2017)
Knowledge-Based Design of a Biosensor to Quantify Localized ERK Activation in Living Cells
Creators: name: Hahn, Klaus M.
name: Hsu, Chia Wen
name: Dokholyan, Nikolay V.
name: Kaufholz, Melanie
name: Zimmermann, Bastian
name: Dagliyan, Onur
name: Plückthun, Andreas
name: Kummer, Lutz
name: MacNevin, Christopher
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Investigation of protein activation in living cells is fundamental to understand how proteins are influenced by the full complement of upstream regulators they experience. We describe here the generation of a biosensor based on the Designed Ankyrin Repeat Protein (DARPin) binding scaffold suited for intracellular applications. Combining selection and evolution from libraries, knowledge-based design and efficient and rapid testing of conjugate candidates, we created an ERK activity biosensor by derivatizing a DARPin specific for phosphorylated ERK (pERK) with a solvatochromic merocyanine dye (mero87), whose fluorescence increases upon pERK binding. The biosensor specifically responded to pERK2, recognized by its conformation, but not to non-phosphorylated ERK2 or other closely related mitogen-activated kinases tested. Activated endogenous ERK was visualized in mouse embryo fibroblasts incubated in 2% serum, revealing greater activation in the nucleus, perinuclear regions, and especially the nucleoli. Activity was greatly reduced by the MEK1/2 inhibitor U0126. The DARPin-based biosensor will serve as useful tool for studying biological functions of ERK in vitro and in vivo.
A Cell-Permeable Inhibitor to Trap Gαq Proteins in the Empty Pocket Conformation
Creators: name: Galés, Céline
name: Kostenis, Evi
name: Holzgrabe, Ulrike
name: Schmitz, Anna Lena
name: Fleischmann, Bernd K.
name: Gomeza, Jesús
name: Hennen, Stephanie
name: Häußler, Daniela
name: Wenzel, Daniela
name: Schrage, Ramona
name: Mohr, Klaus
name: Horn, Velten
name: Sondek, John
name: Schmidt, Johannes
name: Gütschow, Michael
name: Tüting, Thomas
name: Tietze, Daniel
name: Grundmann, Manuel
name: Charpentier, Thomas H.
name: Brewitz, H. Henning
name: Gaffal, Evelyn
name: Morschel, Julia
name: Wiest, Johannes
name: Imhof, Diana
name: Hiltensperger, Georg
name: Büllesbach, Katrin M.
name: Harden, T. Kendall
name: Schröder, Ralf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In spite of the crucial role of heterotrimeric G proteins as molecular switches transmitting signals from G protein-coupled receptors, their selective manipulation with small molecule, cell-permeable inhibitors still remains an unmet challenge. Here, we report that the small molecule BIM-46187, previously classified as pan-G protein inhibitor, preferentially silences Gαq signaling in a cellular context-dependent manner. Investigations into its mode of action reveal that BIM traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry, a molecular mechanism not yet assigned to any other small molecule Gα inhibitor to date. Our data show that Gα proteins may be “frozen” pharmacologically in an intermediate conformation along their activation pathway and propose a pharmacological strategy to specifically silence Gα subclasses with cell-permeable inhibitors.
Additional file 1 of Complicated versus complexity: when an old woman and her daughter meet the health care system
Creators: name: Levander, Märta Sund
name: Tingström, Pia
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1. Interview guide
title: The effect of an interactive dedicated training program on the learning curve in bladder mpMRI interpretation using VI-RADS.
Creators: name: Dehghanpour, Ailin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Oncology
subject: Urinary Tract / Bladder
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Education
subject: Structured reporting
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The purpose of this study was to assess the learning curve of radiology residents’ accuracy in interpretating bladder cancer mpMRI using Vesical Imaging-Reporting and Data System(VI-RADS) in the setting of an interactive dedicated training program...
(401422) Margaret Blair
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Araucaria Project: The First-Overtone Classical Cepheid in the Eclipsing System OGLE-LMC-CEP-2532
Creators: name: Pilecki, B.
name: Graczyk, D.
name: Gieren, W.
name: Pietrzyński, G.
name: Thompson, I. B.
name: Smolec, R.
name: Udalski, A.
name: Soszyński, I.
name: Konorski, P.
name: Taormina, M.
name: Gallenne, A.
name: Minniti, D.
name: Catelan, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present here the first spectroscopic and photometric analysis of the double-lined eclipsing binary containing the classical, first-overtone Cepheid OGLE-LMC-CEP-2532 (MACHO 81.8997.87). The system has an orbital period of 800 days and the Cepheid is pulsating with a period of 2.035 days. Using spectroscopic data from three high-class telescopes and photometry from three surveys spanning 7500 days we are able to derive the dynamical masses for both stars with an accuracy better than 3%. This makes the Cepheid in this system one of a few classical Cepheids with an accurate dynamical mass determination (M_1=3.90 +/- 0.10 M_sun). The companion is probably slightly less massive (3.82 +/- 0.10 M_sun), but may have the same mass within errors (M_2/M_1= 0.981 +/- 0.015). The system has an age of about 185 million years and the Cepheid is in a more advanced evolutionary stage. For the first time precise parameters are derived for both stars in this system. Due to the lack of the secondary eclipse for many years not much was known about the Cepheid's companion. In our analysis we used extra information from the pulsations and the orbital solution from the radial velocity curve. The best model predicts a grazing secondary eclipse shallower than 1 mmag, hence undetectable in the data, about 370 days after the primary eclipse. The dynamical mass obtained here is the most accurate known for a first-overtone Cepheid and will contribute to the solution of the Cepheid mass discrepancy problem.
description: 15 pages, 9 figures, accepted for publication in ApJ
Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70
Creators: name: Bodoor, Khaldon
name: Darr, David B.
name: Hughes, Philip F.
name: Brodsky, Jeffrey L.
name: Jordan, Jamie L.
name: Carlson, David A.
name: Thiele, Dennis J.
name: Hunter, Lucas M.
name: Spector, Neil L.
name: Howe, Matthew K.
name: Jaeger, Alex M.
name: Alwarawrah, Yazan
name: Loiselle, David R.
name: Molzberger, Eileen T.
name: Gobillot, Theodore A.
name: Haystead, Timothy A.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Inducible Hsp70 (Hsp70i) is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis, poor outcomes, and resistance to chemotherapy in patients. Identification of small molecule inhibitors selective for Hsp70i could provide new therapeutic tools for cancer treatment. In this work, we used fluorescence-linked enzyme chemoproteomic strategy (FLECS) to identify HS-72, an allosteric inhibitor selective for Hsp70i. HS-72 displays the hallmarks of Hsp70 inhibition in cells, promoting substrate protein degradation and growth inhibition. Importantly, HS-72 is selective for Hsp70i over the closely related constitutively active Hsc70. Studies with purified protein show HS-72 acts as an allosteric inhibitor, reducing ATP affinity. In vivo HS-72 is well-tolerated, showing bioavailability and efficacy, inhibiting tumor growth and promoting survival in a HER2+ model of breast cancer. The HS-72 scaffold is amenable to resynthesis and iteration, suggesting an ideal starting point for a new generation of anticancer therapeutics targeting Hsp70i.
La tutela dei diritti fondamentali nel contesto cibernetico. Profili di diritto interno, internazionale e dell'Unione europea
Creators: name: FORTI, MIRKO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The main goal of this research is to define a complete human rights framework which could be relevant in the context of cyberspace, therefore to analyze how this kind of rights are enforced and protected under European Union law. Furthermore, my thesis would like to underline any deficit of the European legislation in this respect, thus proposing any improvements to guarantee effective enforcement of the human rights framework in the context of cyberspace. The first part of the thesis aims to address a preliminary issue, namely what is cyberspace and how this new ?environment? can be defined. Furthermore, to evaluate the actual human rights enforcement in this context, it is necessary to answer a very important question: what rules should govern cyberspace? In other words, the thesis intends to analyze the topic of cyber governance, with the purpose of individuating what entities can establish their rules over this new domain. The second introduces the several human rights relevant into the cyberspace, proposing also a complete analysis of each one of them, to evaluate their effectiveness and enforcement.
title: Thoraco-Abdomino-Pelvic Vascular Anatomical Variants – Incidental Findings In Computed Tomography
Creators: name: Toma, Oana-Mihaela
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Arteries / Aorta
subject: Vascular
subject: CT
subject: Venous access
subject: Arteriovenous malformations
subject: Blood
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aim of our study was to establish the prevalence of chest-abdominal-pelvic vascular anatomical variants and comparison with the present results in the...
I. Linguistic research in progress (Part I) – Acknowledgements. Editor’s introduction
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: Contents 1. General remarks 2. The Forschungskolloquium Integrative Sprachwissenschaft 2.1 Origin of the Colloquium 2.2 Period and size of activity 2.3 Membership and language 2.4 Aim 2.5 The topics 3. The documentation: the Proceedings 3.1 Size, method, and aims of the documentation 3.2 What is being published 3.3 Arrangement of text 3.4 Production details 3.5 The text and its 22 Parts. Identifiers 4. Background 4.1 The Integrational framework 4.2 On theories 4.3 Three kinds of linguistic theories 5. Current relevance of the Proceedings 5.1 Five relevance claims 5.2 Claim 1: conceptual work 5.3 Claim 2: work on the conceptual core of a theory of language 5.4 Claims 3 and 4: choice of topics and semantic approach 5.5 Claim 5: questions of method 6. The Proceedings and the Integrational Linguistics mini-series
title: Acute small bowel: the many faces.
Creators: name: Anjum, Osama
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: Small bowel
subject: CT
subject: Education
subject: Acute
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: 1. To illustrate a spectrum of acute small bowel findings encountered on CT. 2. To highlight useful tips and imaging signs with relevant clinico-pathological correlation. 3. To discuss imaging pitfalls and...
Validating the fragment-based drug discovery strategy for targeting biological RNAs: Lead fragments specifically bind and remodel the TPP riboswitch
Creators: name: Ferré-D'Amaré, Adrian R.
name: Abell, Chris
name: Weeks, Kevin M.
name: Homan, Philip
name: Smith, Alison G.
name: Warner, Katherine Deigan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Previous studies using fragment-based approaches identified small molecule “fragments” that bind this gene-regulatory mRNA domain. Crystallographic studies now show that, despite having micromolar Kds, four different fragments bind the TPP riboswitch site-specifically, occupying the pocket that recognizes the aminopyrimidine of TPP. Unexpectedly, the unoccupied site that would recognize the pyrophosphate of TPP rearranges into a structure distinct from that of the cognate complex. This idiosyncratic fragment-induced conformation, also characterized by small-angle X-ray scattering (SAXS) and chemical probing (SHAPE), represents a possible mechanism for adventitious ligand discrimination by the riboswitch, and suggests that off-pathway conformations of RNAs can be targeted for drug development. Our structures, together with previous screening studies, demonstrate the feasibility of fragment-based drug discovery against RNA targets.