cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation
Creators: name: Sharma, Anjaney
name: Gogoi, Prerana
name: Chandravanshi, Monika
name: Kanaujia, Shankar Prasad
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Caspases are cysteine-dependent aspartate-specific proteases that play a crucial role in apoptosis (or programmed cell death) and inflammation. Based on their function, caspases are majorly categorized into apoptotic (initiator/apical and effector/executioner) and inflammatory caspases. Caspases undergo transition from an inactive zymogen to an active caspase to accomplish their function. This transition demands structural rearrangements which are most prominent at the active site loops and are imperative for the catalytic activity of caspases. In effector caspase-3, the structural rearrangement in the active site loop is shown to be facilitated by a set of invariant water (IW) molecules. However, the atomic details involving their role in stabilizing the active conformation have not been reported yet. Moreover, it is not known whether water molecules are essential for the active conformation in all caspases. Thus, in this study, we located IW molecules in initiator, effector, and inflammatory caspases to understand their precise role in rendering the structural arrangement of active caspases. Furthermore, IW molecules involved in anchoring the fragments of the protomer and rendering regulated flaccidity to caspases were identified. Location and identification of IW molecules interacting with amino acid residues involved in establishing the active conformation in the caspases might facilitate the design of potent inhibitors during up-regulated caspase activity in neurodegenerative and immune disorders. Communicated by Ramaswamy H. Sarma
Supplementary Information from Pair formation in insect swarms driven by adaptive long-range interactions
Creators: name: Gorbonos, Dan
name: Puckett, James G.
name: Vaart, Kasper Van Der
name: Sinhuber, Michael
name: Ouellette, Nicholas T.
name: Gov, Nir S.
Publisher: name: The Royal Society
Year: 2020
Subjects: Biophysics
Computational Biology

description: Supplementary Information
การถ่ายทอดทางสังคมเชิงวิชาชีพ ความยึดมั่นในวิชาชีพ ความเชื่อด้านจริยธรรม และความสงสัยเยี่ยงผู้ประกอบวิชาชีพบัญชีของนักศึกษาการบัญชี
Creators: name: วรวิทย์ เลาหะเมทนี
name: โสภิดา สัมปัตติกร
name: วรีวรรณ เจริญรูป
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: การถ่ายทอดทางสังคมเชิงวิชาชีพ, ความยึดมั่นในวิชาชีพ, ความเชื่อด้านจริยธรรม, ความสงสัยเยี่ยงผู้ประกอบวิชาชีพบัญชี, นักศึกษาสาขาการบัญชี

description: วารสารพฤติกรรมศาสตร์, 24, 1
Sharing is caring. Archiving social media together
Creators: name: Weyns, Katrien
Publisher: name: Zenodo
Year: 2024

description: KADOC-KU Leuven investigated best practices for sustainable social media archiving by cultural heritage institutions. Pilot projects explored tools for capturing, archiving, making accessible and the legal framework for these processes.    

During the project it became increasingly difficult or even impossible to extract data from widely used social media platforms, e.g. Facebook or X(Twitter). The main problem is increasingly about getting access to social media data, will your request be granted, in addition to the technical aspect, how to collect the volatile data itself.

These challenges are similar for researchers as for GLAM (galleries, libraries, archives and museums). The contribution lists common challenges and opportunities for collaboration between GLAM and researchers to archive social media for research puposes. It is an invitation for DH researchers to engage in conversation with the heritage sector.
ปัจจัยที่ส่งผลต่อพฤติกรรมป้องกันการสูบบุหรี่ในกลุ่มวัยรุ่น: การสังเคราะห์งานวิจัย ด้วยการทบทวนวรรณกรรมอย่างเป็นระบบ
Creators: name: ชาริน สุวรรณวงศ์
name: ศรัณย์ พิมพ์ทอง
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: การป้องกันการสูบบุหรี่, วัยรุ่น, การทบทวนวรรณกรรมอย่างเป็นระบบ, การสังเคราะห์งานวิจัย

description: วารสารพฤติกรรมศาสตร์, 24, 1
รูปแบบความสัมพันธ์เชิงสาเหตุของปัจจัยทางจิตสังคมที่ส่งผลต่อพฤติกรรมการเรียน ผ่านสื่ออิเล็กทรอนิกส์ ของนักศึกษาระดับปริญญาตรี
Creators: name: ปิยะ บูชา
name: อังศินันท์ อินทรกำแหง
name: จินตนา ตันสุวรรณนนท์
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: พฤติกรรมการเรียนผ่านสื่ออิเล็กทรอนิกส์, เจตนาเชิงพฤติกรรม, การรับรู้การควบคุมพฤติกรรม, เจตคติต่อการเรียนผ่านสื่ออิเล็กทรอนิกส์, การสนับสนุนทางสังคม, แรงจูงใจใฝ่สัมฤทธิ์

description: วารสารพฤติกรรมศาสตร์, 24, 1
โครงสร้างความสัมพันธ์เชิงสาเหตุของการเป็นแฟนฟุตบอลทีมสโมสรฟุตบอลไทยแลนด์พรีเมียร์ลีก และพฤติกรรมการเป็นแฟนฟุตบอลที่ส่งผลต่อสุขภาวะทางสังคมและสุขภาพจิต
Creators: name: สุรเดช ประยูรศักดิ์
name: นำชัย ศุภฤกษ์ชัยสกุล
name: กาญจนา ภัทราวิวัฒน์
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: พฤติกรรมแฟนฟุตบอล, สุขภาวะทางสังคม, สุขภาพจิต, ไทยแลนด์พรีเมียร์ลีก

description: วารสารพฤติกรรมศาสตร์, 24, 1
Structural investigation, DNA interactions and in vitro anticancer studies of transition metal complexes of 3-(2-(2, 4-dihydroxy benzylidene) hydrazinyl) quinoxalin-2(1H) -one
Creators: name: Sukanya, Panaganti
name: Reddy, Chittireddy Venkata Ramana
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The Schiff base ligand, 3-(2-(2, 4-dihydroxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (RHQO) has been synthesized and characterized by spectral and single crystal X-ray analysis. The Mn(II), Ni(II) and Cu(II) complexes of RHQO have been synthesized and characterized by FT-IR, UV-VIS, mass, EPR spectra, CHN, thermo gravimetric analysis, magnetic susceptibility and conductivity measurements. The morphology of the ligand and complexes is studied by Scanning Electron Microscopy. The metal complexes formed were found to be polymeric in nature. The abilities of the ligand and its metal complexes to interact and bind with calf thymus DNA (CT-DNA) has been studied by electronic absorption spectroscopy and their quantitative binding strength was evaluated in terms of their intrinsic binding constant (Kb). The cleavage interaction of the ligand and its metal complexes with super coiled pBR 322 DNA has been investigated by agarose gel electrophoresis. Cytotoxicity of the Cu(II) and Ni(II) complexes was evaluated using various cancer cell lines, Human cervical cancer cell line (Hela), B16 melanoma F10(B16-F10), Human ovarian cancer cell (SKOV3) and Breast cancer cell line (MCF7) by MTT assay. The results indicated that the ligand and its metal complexes bind with CT-DNA by groove binding mode and cleaved the supercoiled pBR 322 DNA in to nicked form. The Ni(II) and Cu(II) complexes exhibited anticancer activity without affecting the normal CHO-K1 cell lines. Communicated by Vsevolod Makeev
จิตวิทยาการปรึกษากับการสร้างความเป็นธรรมทางสังคม
Creators: name: นันท์ชัตสัณห์ สกุลพงศ์
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: จิตวิทยา, การปรึกษา, ความเป็นธรรม

description: วารสารพฤติกรรมศาสตร์, 24, 1
Molecular elucidation of pancreatic elastase inhibition by baicalein
Creators: name: Ghosh, Debajeet
name: Bansode, Sneha
name: Joshi, Rakesh
name: Kolte, Baban
name: Gacche, Rajesh
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: The serine protease, elastase exists in various forms and plays diverse roles in the human body. Pharmacological inhibition of elastase has been investigated for its therapeutic role in managing conditions such as diabetes, pneumonia and arthritis. Sivelestat, a synthetic molecule, is the only elastase inhibitor to have been approved by any major drug regulatory authority (PMDA, in this case) – but still has failed to attain widespread clinical usage owing to its high price, cumbersome administration and obscure long-term safety profile. In order to find a relatively better-suited alternative, screening was conducted using plant flavonoids, which yielded baicalein, a molecule that showed robust inhibition against Pancreatic Elastase inhibition (IC50: 3.53 μM). Other than having a considerably lower IC50than sivelestat, baicalein is also cheaper, safer and easier to administer. While MicroScale Thermophoresis validated baicalein-elastase interaction, enzyme-kinetic studies, molecular docking and molecular dynamic simulation revealed the mode of inhibition to be non-competitive. Baicalein exhibited binding to a distinct allosteric site on the enzyme. The current study demonstrates the elastase inhibition properties of baicalein in an in-vitro and in-silico environment. Communicated by Ramaswamy H. Sarma
Revisiting the Circulation of Hudson Bay: Evidence for a Seasonal Pattern
Creators: Ridenour, Natasha A.
Hu, Xianmin
Sydor, Kevin
Myers, Paul G.
Barber, David G.
Publisher: name: University of Alberta Library
Year: 2019

The Hudson Bay Complex is the outlet for many Canadian rivers, receiving roughly 900 km3/year of river runoff. Historically, studies found a consistent cyclonic flow year-round in Hudson Bay, due to the geostrophic boundary current induced by river discharge and cyclonic wind forcing that was supported by available observations at that time. Using a high-resolution ocean general circulation model, we show that in summer, the mean circulation is not cyclonic but consists of multiple small cyclonic and anticyclonic features, with the mean flow directed through the center of the bay. Absolute Dynamic Topography and velocity observations also show this seasonal flow pattern. We find that this summer circulation is driven by geostrophic currents, generated by steric height gradients, which are induced by increased river discharge during the spring freshet, and reinforced by anticyclonic seasonal wind patterns.
การเรียนรู้สู่การเปลี่ยนแปลง: ความท้าทายของผู้สอนในระดับอุดมศึกษา
Creators: name: ชนัดดา ภูหงษ์ทอง
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: การเรียนรู้สู่การเปลี่ยนแปลง, การสอน, การศึกษาในระดับอุดมศึกษา

description: วารสารพฤติกรรมศาสตร์, 24, 1
Factors Influencing Transport Productivity of a Freight Transport Company
Creators: name: Bueno-Pascual, Felix Eduardo
name: Martinez-Flores, Jose Luis
name: Omar Caballero Morales, Santiago
name: Moreno, Luis Alberto Barroso
Publisher: name: figshare
Year: 2022
Subjects: subject: 150309 Logistics and Supply Chain Management
subject: FOS: Economics and business

description: The purpose of this paper is to examine what are main factors influencing trucks productivity of a freight transport company in Mexico. This study employed factor analysis to determine if there were a relationship between variables and multiple regression analysis to determine which factors had significant impact in delivery times. Data collected were analyzed using SPSS 23. Regarding factor analysis, it was used Kayser-Meyer-Olkin test to prove if a factorial analysis could be performed, resulting in reduction of variables from 7 to 2 – with a KMO of 0.91 the results are suitable for factor analysis – and Bartlett’s sphericity test to test resulting in 0.0 – which means data structure is suitable – indicating factor analysis and data are useful to achieve research objective. Hence, this study is the base to improve service quality and client perception, by increasing number of fulfilled deliveries. This research is important for the company since it will provide insights about the performance of their logistics process and variables to be controlled to improve trucks efficiency and productivity.
Actisecidae Harmer 1957
Creators: name: Cáceres-Chamizo, Julia P.
name: Sanner, Joann
name: Tilbrook, Kevin J.
name: Ostrovsky, Andrew N.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Gymnolaemata
Cheilostomatida
Actisecidae

description: Family Actisecidae Harmer, 1957
Canu and Bassler (1929) described Exechonella discoidea as a new species from Philippines with umbonuloid frontal shield being very similar to that in Exechonella. Presence of the ovicells, however, does not allow its attribution to this genus. Earlier from the same area these authors described another cheilostome with similar frontal shield as Actisecos regularis Canu & Bassler, 1927 (also described in their 1929 paper). The latter species was redescribed by Harmer (1957), based on the specimens from Indonesia and New Guinea. This author has also introduced the family Actisecidae. To avoid confusions with exechonellid species in the future, we studied and redescribed the specimens of Canu and Bassler.
description: Published as part of Cáceres-Chamizo, Julia P., Sanner, Joann, Tilbrook, Kevin J. & Ostrovsky, Andrew N., 2017, Revision of the Recent species of Exechonella Canu & Bassler in Duvergier, 1924 and Actisecos Canu & Bassler, 1927 (Bryozoa, Cheilostomata): systematics, biogeography and evolutionary trends in skeletal morphology, pp. 1-79 in Zootaxa 4305 (1) on page 65, DOI: 10.11646/zootaxa.4305.1.1, http://zenodo.org/record/842587
Graphene utilized as a ligand in organometallic “piano-stool” complexes and the impact on conductivity
Creators: name: Ademuwagun, Oluwafemi
Publisher: name: No Publisher Supplied
Year: 2022

description: The purpose of this thesis is to investigate the effect on field effect transistors when using graphitic materials fabricated with “piano stool” or cyclic polyhapto compounds. Graphene’s superior electrical and thermal conductivity has already been proven to result in lower resistance losses and enhance heat dissipation compared to silicon. Consequently, graphene-based transistors have the potential to provide enhanced performance and efficiency. Research has also shown that the electronic properties of graphene can be improved by fabrication with transition metal complexes having a vacant d-orbital. This paper builds on the work started by Dr. Haddon’s group and aims to synthesize new materials of graphitic compounds with “piano stool” compounds. The extended periodic π-electron systems of graphene exhibited some degree of reactivity toward Cr(CO)6 and (η6- benzene)Cr(CO)3 and complexation with graphene by removing the labile CO ligand is indicated. To understand the trends in the chemistry and stability of the complexes based on molecular interactions and surface environments, ATR-IR, Raman Spectroscopy, and XPS were conducted. To evaluate the conductivity, a four-probe measurement of sheet resistance was performed. The cyclic polyhapto complexes of graphene are expected to have improved electronic properties relative to the starting graphitic materials which will be ideal in FET applications, but scalability remains an issue.
Fluorinated ethylene-propylene copolymer powders having improved adhesion to substrates and method
Creators: name: Arkles, Barry C.
name: Gerakaris, Stephen
Publisher: name: Zenodo
Year: 1978
Subjects: Fluoropolymers
Radiation processing
Fluorinated Ethylene-Propylene
Powder Coating
tetrafluoroethylene copolymers

description: Melt-processible fluorinated ethylene-propylene co polymer powders may be rendered more adherent to substrates, particularly metal substrates, by irradiating the copolymer powder with about 0.5 to 6 megarads of radiation, and preferably about 2 to 4 megarads. The copolymer powder should have a maximum particle size of about 420 microns, and the particles should preferably range in diameter from about 177 to 420 microns. The irradiation increases the melt index of the copolymer, preferably by a factor of about 2 to 10. As a result, the powder has improved flow properties and may be more easily milled to a smaller particle size for application to a substrate. The adhesion of the irradiated powder to metal substrates is improved by a factor of about 2 to 3.
On the kinetics of homogeneous nucleation of incoherent precipitates in solid solutions
Creators: name: Veshchunov, M. S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: By critically examining the traditional theory of homogeneous nucleation of precipitates in solid solutions, it is revealed that the theory's assertion regarding an increase in the nucleation free energy due to elastic strain associated with the difference in atomic volumes between the two phases is applicable to coherent precipitates, but becomes incorrect when applied to incoherent precipitates. This conclusion is obtained by accounting for thermal point defects in the matrix, which can be absorbed at the interface between an incoherent particle and the matrix during nucleation, thereby relieving elastic stresses. Accordingly, a new kinetic model based on the Reiss theory for binary nucleation is proposed for predicting the nucleation rate of incoherent precipitates by agglomeration of solute atoms and point defects, with a further extension to account for excess vacancies formed under non-equilibrium conditions of quenching experiments.
description: Published in Russian Zhurnal Eksperimental'noi i Teoreticheskoi Fiziki 165 (2024) 214-225
Synthesis And Optical Characterization Of Yittrium Doped Cerium Oxide Nanoparticles
Creators: name: R.Thirumamagal
name: S.Nivetha
name: K.Kaviyarasu
name: A.Ayeshamariam
name: M.Valanarasu
name: M.Jayachandran
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Actisecos Canu & Bassler 1927
Creators: name: Cáceres-Chamizo, Julia P.
name: Sanner, Joann
name: Tilbrook, Kevin J.
name: Ostrovsky, Andrew N.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Gymnolaemata
Cheilostomatida
Actisecidae
Actisecos

description: Genus Actisecos Canu & Bassler, 1927
Type species: Actisecos regularis Canu & Bassler, 1927
Diagnosis. Colonies free, discoidal, small (no more than four zooidal generations were observed), slightly or strongly convex. Zooids small, elongated. Peristome long, cylindrical, swollen in the base, with pustulose surface. Primary orifice subcircular. Frontal shield centrally smooth or with sporadic tubercules that are more common on the periphery, with few (nine to 19) foramina. Basal pore chambers with 1–2 communication pore(s). Marginal pores absent. Basal autozooidal walls covered by flat kenozooids with large membranous area. No avicularia. Ovicells prominent, peristomial, terminal, developing exclusively in the peripheral zooids. Ectooecium membranous, entooecium pustulose with numerous pseudopores. Ancestrula is autozooidal in shape, surrounded by six zooids.
description: Published as part of Cáceres-Chamizo, Julia P., Sanner, Joann, Tilbrook, Kevin J. & Ostrovsky, Andrew N., 2017, Revision of the Recent species of Exechonella Canu & Bassler in Duvergier, 1924 and Actisecos Canu & Bassler, 1927 (Bryozoa, Cheilostomata): systematics, biogeography and evolutionary trends in skeletal morphology, pp. 1-79 in Zootaxa 4305 (1) on page 65, DOI: 10.11646/zootaxa.4305.1.1, http://zenodo.org/record/842587
Strategic Empowerment: Japan’s Evolving Policy toward Southeast Asia from the 2010s
Creators: name: Koga, Kei
Publisher: name: International Quarterly for Asian Studies
Year: 2024

description: How has Japan developed its Southeast Asian strategy in the context of the intensifying US-China rivalry since the 2010s? This article argues that the rapidly changing strategic environment brought about by the assertive rise of China prompted Japan to adopt a new strategic vision that went beyond the traditional geographical focus on East Asia. Japan has gradually positioned Southeast Asia as one of the most important strategic theatres in the Indo-Pacific. Utilising its existing economic and diplomatic leverage in Southeast Asia, Japan has been pursuing various types of capacity-building strategies to empower Southeast Asian states and ASEAN to maintain regional autonomy, which the author calls “strategic empowerment”. While Japan has engaged in similar cooperative activities in the past, it has renewed its commitment through three main means: building a strategic partnership in Southeast Asia; promoting international rules, norms and values; and strengthening ASEAN-led institutions.
description: International Quarterly for Asian Studies, Vol. 55 No. 1 (2024): Mutual Transformations – Southeast Asia and Japan in the 21st Century
title: The Evolution and Unraveling of the American Eugenics Movement
Creators: name: Walton, Anneka
Publisher: name: Utah State University
Year: 2022

description: While the evolution of American eugenics surrounding the time of Nazi Germany has been well-documented, the periods before the explosion of American eugenics and the result of the movement in the wake of the Holocaust are not so well known. Many historically-based works have described the path and growth of eugenics from the time the term was coined to the public acknowledgement of World War II and the point where Americans ended eugenic euthanasia and slowed eugenic sterilizations. There are also many works within the realm of disability history that document these events from the more common social viewpoint. This study provides an analysis of historical sources, primarily textbooks or medical references, from the earliest beginnings of eugenic ideas through to the 1970s where the term “eugenics” faded out of the public spotlight, with a particular aim to describe the early beginnings of the eugenics movement and additional details on how eugenics as a concept faded from its peak to where we are now. Surprisingly, it appears that eugenic ideals did in fact exist long before the term was coined, especially among the social elite and highly religious, who felt it was their duty to God to ensure they replenished the earth with healthy children. In studying textbooks published a few years after the holocaust came to public awareness as a moral atrocity, it also became clear that Americans still believed in their eugenics movement, yet sought to separate what was done here as a social and humanitarian movement from the acts of Hitler. Instead of the American eugenics movement suddenly blinking quickly in and out of existence, this study has found that the movement had deep roots before being named, and phased out very slowly, with a few of its roots remaining today without the “eugenics” label.
Japan’s Coast Guard Capacity Building under Abe Shinzō: Between Power, Money and Norms
Creators: name: Yamamoto, Raymond
Publisher: name: International Quarterly for Asian Studies
Year: 2024

description: For Japan’s former prime minister Abe Shinzō, security cooperation with Southeast Asia was central to preventing the South China Sea from turning into a “Lake Beijing” – completely under Chinese control. This paper explains why Abe’s security engagement in the region focused mainly on providing Capacity Building Assistance (CBA) to Southeast Asian coast guards agencies to counter China’s maritime assertiveness. Answers are provided by looking at not only international but also domestic factors. Based on key variables of post–Cold War Japan’s foreign policy, namely the US-Japan alliance, the dominance of economic tools, and normative and institutional constraints on the use of force, the analysis concludes that CBA was an ideal response to the complex demands and restrictions of Japan’s security policy. In particular, the economic benefits of providing CBA are an important finding of the analysis and one that has not yet received much scholarly focus.
description: International Quarterly for Asian Studies, Vol. 55 No. 1 (2024): Mutual Transformations – Southeast Asia and Japan in the 21st Century
In silico evaluation of lapachol derivatives binding to the Nsp9 of SARS-CoV-2
Creators: name: Junior, Nilson Nicolau
name: Santos, Igor Andrade
name: Meireles, Bruno Amaral
name: Nicolau, Mariana Sant’Anna Pereira
name: Lapa, Igor Rodrigues
name: Aguiar, Renato Santana
name: Jardim, Ana Carolina Gomes
name: José, Diego Pandeló
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SARS-CoV-2 is the etiological agent of COVID-19, which represents a global health emergency that was rapidly declared a pandemic by the World Health Organization. Currently, there is a dearth of effective targeted therapies against viruses. Natural products isolated from traditional herbal plants have had a huge impact on drug development aimed at various diseases. Lapachol is a 1,4- naphthoquinone compound that has been demonstrated to have therapeutic effects against several diseases. SARS-CoV-2 non-structural proteins (nsps) play an important role in the viral replication cycle. Nsp9 seems to play a key role in transcription of the RNA genome of SARS-CoV-2. Virtual screening by docking and molecular dynamics suggests that lapachol derivatives can interact with Nsp9 from SARS-CoV-2. Complexes of lapachol derivatives V, VI, VIII, IX, and XI with the Nsp9 RNA binding site were subjected to molecular dynamics assays, to assess the stability of the complexes via RMSD. All complexes were stable over the course of 100 ns dynamics assays. Analyses of the hydrogen bonds in the complexes showed that lapachol derivatives VI and IX demonstrated strongest binding, with a stable or increasing number of hydrogen bonds over time. Our results demonstrate that Nsp9 from SARS-CoV-2 could be an important target in prospecting for ligands with antiviral potential. In addition, we showed that lapachol derivatives are potential ligands for SARS-CoV-2 Nsp9. Communicated by Ramaswamy H. Sarma
title: A=A: A Change in Social Movement Engagement and Leadership Should Equal a Change in Civic Education
Creators: name: Tureson, Tess
Publisher: name: Utah State University
Year: 2022

description: It seems as if almost everything in our world has changed with the introduction of the internet, personal computers, iPhones, and social media. We write emails instead of letters. We listen to podcasts and read articles online instead of buying a newspaper. Presidents communicate with the world on Twitter. The way we engage with politics has entirely changed. Yet, we are still going about civic education in schools the same way, teaching students to give speeches in city council meetings, write letters to their representative, and find current events from traditional news sources. This study offers new statistical evidence that the way people interact with social movements, how they rise to lead them, and who it is that gets to lead has all started to change in correlation with onset of widespread social media use. This study looks at the socioeconomic status (i.e., a combination of their education, job prestige, and income) of the leaders of social movements, showing that on average their status has lowered since politics has moved to be increasingly conducted online. We are seeing a wider age-range in social movement leadership as leaders operate behind screens. This study also looks at two case studies to decipher the differences between movements that started before social media and movements that began after the most common platforms were already in place. The change is happening, and it’s time it reached our schools as well.
Credible, Unreliable or Leaked?: Evidence Verification for Enhanced Automated Fact-checking
Creators: name: Chrysidis, Zacharias
name: Papadopoulos, Stefanos-Iordanis
name: Papadopoulos, Symeon
name: Petrantonakis, Panagiotis C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: Computers and Society (cs.CY)
subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Automated fact-checking (AFC) is garnering increasing attention by researchers aiming to help fact-checkers combat the increasing spread of misinformation online. While many existing AFC methods incorporate external information from the Web to help examine the veracity of claims, they often overlook the importance of verifying the source and quality of collected "evidence". One overlooked challenge involves the reliance on "leaked evidence", information gathered directly from fact-checking websites and used to train AFC systems, resulting in an unrealistic setting for early misinformation detection. Similarly, the inclusion of information from unreliable sources can undermine the effectiveness of AFC systems. To address these challenges, we present a comprehensive approach to evidence verification and filtering. We create the "CREDible, Unreliable or LEaked" (CREDULE) dataset, which consists of 91,632 articles classified as Credible, Unreliable and Fact checked (Leaked). Additionally, we introduce the EVidence VERification Network (EVVER-Net), trained on CREDULE to detect leaked and unreliable evidence in both short and long texts. EVVER-Net can be used to filter evidence collected from the Web, thus enhancing the robustness of end-to-end AFC systems. We experiment with various language models and show that EVVER-Net can demonstrate impressive performance of up to 91.5% and 94.4% accuracy, while leveraging domain credibility scores along with short or long texts, respectively. Finally, we assess the evidence provided by widely-used fact-checking datasets including LIAR-PLUS, MOCHEG, FACTIFY, NewsCLIPpings+ and VERITE, some of which exhibit concerning rates of leaked and unreliable evidence.
Reinforcing Trust, Evoking Nostalgia and Contrasting China: Japan’s Foreign Policy Repertoire and Identity Construction in Myanmar
Creators: name: Lindgren, Wrenn Yennie
Publisher: name: International Quarterly for Asian Studies
Year: 2024

description: In the immediate aftermath of the military coup in Myanmar in February 2021, Western countries and the EU condemned the  coup, imposed targeted sanctions against military leaders and military-­owned companies, and redirected essential humanitarian aid to NGOs. Japan, however, chose to neither align with its democratic allies nor completely suspend its aid. Despite a long and complicated pre-war history and limited engagement after 1988, Japan-Myanmar relations experienced a resurgence between 2012 and 2021. This article contends that one key driving force in contemporary relations is identity construction. Drawing on the literature on relational identity and foreign policy repertoires, the article demonstrates how the discursive statements and embodied practices of a network of Japanese identity entrepreneurs activate, negotiate and renegotiate the identities of the Japanese Self and its Others. Through an analysis of interviews conducted with elite stakeholders in Myanmar and Japan, the article studies Japan’s constructed identity as an economic great power and post-war development pioneer, peace promoter and diplomatic mediator. It finds that Japan constructs its identity temporally in terms of nostalgia (natsukashisa) and a longing for a time when Japan was a post-war industrial powerhouse, but also spatially in terms of Japan’s legal, moral and industrial superiority over other countries involved in Myanmar’s development, in particular vis-à-vis China.
description: International Quarterly for Asian Studies, Vol. 55 No. 1 (2024): Mutual Transformations – Southeast Asia and Japan in the 21st Century
โครงสร้างความสัมพันธ์เชิงสาเหตุและผลพหุระดับของความยึดมั่นผูกพันในงาน ที่มีต่อพฤติกรรมการสร้างนวัตกรรมของพนักงานบริษัทแห่งหนึ่งในกลุ่มซิเมนต์ และวัสดุก่อสร้าง
Creators: name: ไพฑูรย์ ฮั่นตระกูล
name: ยุทธนา ไชยจูกุล
name: อดิลล่า พงศ์ยี่หล้า
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: ความยึดมั่นผูกพันในงาน, พฤติกรรมการสร้างนวัตกรรม,แบบจำลองสมการโครงสร้าง พหุระดับ

description: วารสารพฤติกรรมศาสตร์, 24, 1
Using Vertically Integrated Ocean Fields to Characterize Greenland Icebergs’ Distribution and Lifetime
Creators: Marson, Juliana M.
Myers, Paul G.
Hu, Xianmin
Le Sommer, Julien
Publisher: name: University of Alberta Library
Year: 2018

Icebergs represent approximately half of Greenland’s yearly mass loss, having important implications for biological productivity, freshwater fluxes in the ocean, and navigation. This study applies an iceberg model that uses integrated ocean fields (from surface to iceberg keel) to simulate the drift and decay of Greenland icebergs. This version of iceberg model (VERT) is compared with a more widely adopted version (SURF) which only uses surface ocean fields in its equations. We show that icebergs in VERT tend to drift along the shelf break, while in SURF they concentrate along the coastline. Additionally, we show that Greenland’s southeast coast is the source of ∼60% of the icebergs that cross the interior of the Labrador

Sea—a region that stages buoyancy-driven convection and is, therefore, sensitive to freshwater input.
บทวิจารณ์หนังสือ "กรอบการวิเคราะห์การเมืองแบบทฤษฎีขบวนการทางสังคม"
Creators: name: ประภาส ปิ่นตบแต่ง
name: วันชัย ธรรมสัจการ
name: ธงพล พรหมสาขา ณ สกลนคร
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: กรอบการวิเคราะห์การเมือง, ทฤษฎี, ขบวนการทางสังคม

description: วารสารพฤติกรรมศาสตร์, 24, 1
title: Margin of Error
Creators: name: Felty, Aubrey
Publisher: name: Utah State University
Year: 2022

description: According to Utah State University’s Office of Analysis, Assessment, and Accreditation during the Fall semester of 2020, about 18% of students enrolled were students of color. About 2.5% of students enrolled identified as two or more races. Margin of Error is a docudrama that elevates the voices of multiracial college students and promotes a better understanding of multiracial individuals. The project involves actor portrayals of interviews with multiracial college students who discuss navigating their multiple racial identities at often predominantly white universities. It also features reactions and commentary on the students’ experiences from faculty and students at Utah State University. This project was crafted through the devised theatre process. Devising is a subgroup of the larger genre, Applied Theatre, which intends to promote social change through theatre. In this form, “the audience is challenged to explore multiple possibilities within a given oppressive situation, and to actively engage in the theatrical process to attempt to overcome that oppression” (Boal as cited in Mesner, 2018, p. 256).
The specific goals of this project were to:

Elevate the voices of multiracial students.
Provide space for multiracial individuals to discuss and share their stories.
Promote a better understanding of multiracial people.

The research questions that I investigated are as follows:

How do multiracial individuals perform their self-identity in different social contexts?
Do multiracial individuals feel obligated to perform particular racial identities, or aspects of those identities to perform? Why or why not?
How do university demographics affect multiracial individuals' educational experiences?
ประสิทธิผลของโปรแกรมปรับเปลี่ยนพฤติกรรมการดูแลอนามัยการเจริญพันธุ์ ของนักเรียนหญิงที่พิการทางการเคลื่อนไหว
Creators: name: อรุณี ลิ้มมณี
name: ดุษฎี โยเหลา
name: นริสรา พึ่งโพธิ์สภ
Publisher: name: สถาบันวิจัยพฤติกรรมศาสตร์ มศว
Year: 2561
Subjects: โปรแกรมปรับเปลี่ยนพฤติกรรมการดูแลอนามัยการเจริญพันธุ์, การถูกล่วงละเมิดทางเพศ,การป้องกันการตั้งครรภ์ไม่พึงประสงค์, การป้องกันจากโรคติดต่อทางเพศสัมพันธ์, ความพิการทางการเคลื่อนไหว

description: วารสารพฤติกรรมศาสตร์, 24, 1
Repurposing of FDA-approved drugs as autophagy inhibitors in tumor cells
Creators: name: Prerna, Kumari
name: Dubey, Vikash Kumar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Autophagy and apoptosis are the two crucial processes of programmed cell death found in all eukaryotic cells; however, the elevated physiological stress in the tumor microenvironment leads to uncontrolled up-regulation in the process of autophagy. Available literatures suggest that inhibiting up-regulated autophagy in the cancerous cells may lead to the apoptosis and thereby culminate to tumor clearance. Several studies have been performed to design autophagy-inhibitors using either Beclin-1 or Bcl-2 as a target in isolation. However, to overcome the constraints of the availability of small and potent autophagy inhibitors, we have attempted extensive computational approach of repurposing the FDA-approved drugs from the ZINC database in order to inhibit the interaction between the Beclin1 and Bcl-2. Out of 1565 FDA-approved drugs used in our computational work, we sorted the drugs Ponatinib, Simeprevir, and Nilotinib through various methods viz. molecular docking, Lipinski’s filter, MD simulation and MM/PBSA, and we found these aforementioned drugs to show good binding energy and favorable interaction with the BH3 domain of Beclin1. We anticipate from our computational results that these drugs may become potent candidates to inhibit autophagy and exhibit the apoptosis in the tumor microenvironment and combat the current limitation of potent autophagy inhibitors; however, to substantiate our in-silico results, further experimental validations of these drug molecules are currently in progress. Communicated by Ramaswamy H. Sarma
Planet Hunters TESS V: a planetary system around a binary star, including a mini-Neptune in the habitable zone
Creators: name: Eisner, Nora L.
name: Grunblatt, Samuel K.
name: Barragán, Oscar
name: Faridani, Thea H.
name: Lintott, Chris
name: Aigrain, Suzanne
name: Johnston, Cole
name: Mason, Ian R.
name: Stassun, Keivan G.
name: Bedell, Megan
name: Boyle, Andrew W.
name: Ciardi, David R.
name: Clark, Catherine A.
name: Hebrard, Guillaume
name: Hogg, David W.
name: Howell, Steve B.
name: Klein, Baptiste
name: Llama, Joe
name: Winn, Joshua N.
name: Zhao, Lily L.
name: Murphy, Joseph M. Akana
name: Beard, Corey
name: Brinkman, Casey L.
name: Chontos, Ashley
name: Cortes-Zuleta, Pia
name: Delfosse, Xavier
name: Giacalone, Steven
name: Gilbert, Emily A.
name: Heidari, Neda
name: Holcomb, Rae
name: Jenkins, Jon M.
name: Kiefer, Flavien
name: Lubin, Jack
name: Martioli, Eder
name: Polanski, Alex S.
name: Saunders, Nicholas
name: Seager, Sara
name: Shporer, Avi
name: Tyler, Dakotah
name: Van Zandt, Judah
name: Alhassan, Safaa
name: Amratlal, Daval J.
name: Antonel, Lais I.
name: Bentzen, Simon L. S.
name: Bosch, Milton K. D.
name: Bundy, David
name: Chitsiga, Itayi
name: Delaunay, Jérôme F.
name: Doisy, Xavier
name: Ferstenou, Richard
name: Fynø, Mark
name: Geary, James M.
name: Haynaly, Gerry
name: Hermes, Pete
name: Huten, Marc
name: Lee, Sam
name: Metcalfe, Paul
name: Pennell, Garry J.
name: Puszkarska, Joanna
name: Schäfer, Thomas
name: Stiller, Lisa
name: Tanner, Christopher
name: Tarr, Allan
name: Wilkinson, Andrew
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report on the discovery and validation of a transiting long-period mini-Neptune orbiting a bright (V = 9.0 mag) G dwarf (TOI 4633; R = 1.05 RSun, M = 1.10 MSun). The planet was identified in data from the Transiting Exoplanet Survey Satellite by citizen scientists taking part in the Planet Hunters TESS project. Modeling of the transit events yields an orbital period of 271.9445 +/- 0.0040 days and radius of 3.2 +/- 0.20 REarth. The Earth-like orbital period and an incident flux of 1.56 +/- 0.2 places it in the optimistic habitable zone around the star. Doppler spectroscopy of the system allowed us to place an upper mass limit on the transiting planet and revealed a non-transiting planet candidate in the system with a period of 34.15 +/- 0.15 days. Furthermore, the combination of archival data dating back to 1905 with new high angular resolution imaging revealed a stellar companion orbiting the primary star with an orbital period of around 230 years and an eccentricity of about 0.9. The long period of the transiting planet, combined with the high eccentricity and close approach of the companion star makes this a valuable system for testing the formation and stability of planets in binary systems.
description: 24 pages, 16 figures, 4 tables
Preservation And Access To Records With Geodata  (Pilot Definition: Pilot 5)
Creators: name: Završnik. Gregor
name: Domajnko, Boris
name: Skofljanec, Joze
name: Alföldi, István
name: Anderson, David
name: Anderson, Janet
Publisher: name: Zenodo
Year: 2018
Subjects: E-ARK
Pilot
Geodata

description: This technical note sets out the definition of E-ARK Pilot 5: Preservation and access to records with geodata.
title: A Music Composition Through the Use of Animal Sounds
Creators: name: Nguy, Andy
Publisher: name: Utah State University
Year: 2022

description: The knowledge on animals has been studied over many years by researching and understanding animal behavior and creativity with music. Bioacoustics shows a great deal when it comes to collecting sounds through many principles for sound data collection. With saved recording of animals, music, speeches, and so much more, it has impacted the way music is created through technology. Music production has been advancing in many creative ways. The foundation of sound manipulation is musique concrète. The project uses these concepts of audio recording and digital sounds to produce a composition that includes animal sounds.
RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2
Creators: name: Mishra, Avinash
name: Rathore, Anurag S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the control. It was observed that Remdesivir and Galidesivir exhibited similar binding energies for their best docked poses, −6.6 kcal/mole and −6.2 kcal/mole, respectively. ATP also displayed comparative and strong binding free energy of −6.3 kcal/mole in the catalytic site of RdRp. However, their binding locations within the active site are distinct. Further, the interaction of catalytic site residues (Asp760, Asp761, and Asp618) with Remdesivir and Galidesivir is comprehensively examined. Conformational changes of RdRp and bound molecules are demonstrated using 100 ns explicit solvent simulation of the protein-ligand complex. Simulation suggests that Galidesivir binds at the non-catalytic location and its binding strength is relatively weaker than ATP and Remdesivir. Remdesivir also binds at the catalytic site and showed high potency to inhibit the function of RdRp. Binding of co-factor units nsp7 and nsp8 with RdRp (nsp12) complexed with Remdesivir and Galidesivir was also examined. MMPBSA binding energy for all three complexes has been computed across the 100 ns simulation trajectory. Overall, this study suggests, Remdesivir has anti-RdRp activity via binding at a catalytic site. In contrast, Galidesivir may not have direct anti-RdRp activity but it can induce a conformational change in the RNA polymerase. Communicated by Ramaswamy H. Sarma
Johannes Koder, Nomos Georgikos: Das byzantinische Landwirtschaftsgesetz.
Creators: name: Chitwood, Zachary
Publisher: name: The Byzantine Review
Year: 2022

description: Johannes Koder, Nomos Georgikos: Das byzantinische Landwirtschaftsgesetz. Überlegungen zur inhaltlichen und zeitlichen Einordnung. Deutsche Übersetzung (Wiener byzantinistische Studien 32). Wien 2020. 94 pp. – ISBN 978-3-7001-8695-3 (€ 29.90)}
description: The Byzantine Review, Vol. 4 (2022)
Negative allosteric modulators of cannabinoid receptor 1: Ternary complexes including CB1, orthosteric CP55940 and allosteric ORG27569
Creators: name: Aderibigbe, AyoOluwa O.
name: Pandey, Pankaj
name: Doerksen, Robert J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In October 2019, the first X-ray crystal structure of a ternary cannabinoid receptor 1 (CB1) complex (PDB ID: 6KQI) was published, including the well-known orthosteric agonist, CP55940, and the well-studied negative allosteric modulator, ORG27569. Prior to the release of 6KQI, we applied binding pocket analysis and molecular docking to carefully prepared computational models of the ternary CB1 complex, in order to predict the binding site for ORG27569 with the CP55940-bound CB1 receptor. We carefully studied the binding pose of agonist ligands in the CB1 orthosteric pocket, including CP55940. Our computational studies identified the most favorable binding site for ORG27569, in the CP55940–CB1 complex, to be at the intracellular end of the receptor. However, in the 6KQI structure, ORG27569 was found at an extrahelical, intramembrane site on the complex, a site that partially overlaps with the site predicted in our calculations to be second-best. We performed molecular dynamics simulations of the CP55940-bound CB1 complex with ORG27569 at different binding sites. Our analysis of the simulations indicated that ORG27569 bound favorably and stably in each simulation, but, as in the earlier calculations, bound best at the intracellular site, which is different than that found in the crystal structure. These results suggest that the intracellular site might serve as an alternative binding site in CB1. Our studies show that the computational techniques we used are valuable in identifying ligand-binding pockets in proteins, and could be useful for the study of the interaction mode of other allosteric modulators. Communicated by Ramaswamy H. Sarma
title: Ewing sarcoma of the cervical spine presenting as ivory vertebra
Creators: name: Gala, Foram
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Paediatric radiology
subject: Musculoskeletal spine
subject: CT
subject: MR
subject: Neoplasia
subject: Clinical Case

description: Clinical History: A 4-year-old child presented with pain in the neck following trivial trauma one month back. 20 days later, he developed difficulty in standing and walking. On examination, he had reduced power in left upper limb (3/5) and right lower limb (4/5).

description: 4 years, male