cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Restrictions for biodiesel markets growth: an analysis of transaction costs and price transmissions of soybeans from the US to Brazil
Creators: name: Ferreira Frascaroli, Bruno
name: Massaru Da Silva, Murilo
name: Sousa, Evemília
Publisher: name: Italian Review of Agricultural Economics
Year: 2017

description: The present study is aimed to analyze the price transmission of soybeans commodities, the main input for production of biodiesel in Brazil. Our goal was to capture the presence of transaction costs in markets of soybean from a dynamic perspective in the presence of the Law of One Price (LOP). Statistical tests and Vector Error Correction (VEC and TVEC) models were estimated. The results indicated that 1) over the long term, the prices of soybeans and soybean bran quoted in the city of Oeste, Passo Fundo and Rondonópolis tend to follow the changes in commodity price quoted in the CBOT 2) the prices for soybean oil were relatively protected. Also, to developing biodiesel markets in Brazil is necessary minimize the environmental impact of soybean cultivation, mainly on Amazon and Cerrado biomes.
description: Italian Review of Agricultural Economics, Vol 71 No 3 (2016)
title: Under pressure: key imaging features of vascular compression syndromes
Creators: name: Santos Ángel, Ana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Vascular
subject: CT
subject: Education
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To provide an overview of the CT imaging features of vascular compression syndromes in the abdomen and pelvis. To describe the clinical signs and symptoms in order to approach a proper diagnosis. To analyze the role of the radiologist in the...
title: Autoimmune pancreatitis: A pictorial review of the different presentation patterns
Creators: name: Sánchez, Carlos
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Pancreas
subject: CT
subject: MR
subject: MR-Cholangiography
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To know the main characteristics of this entity, reviewing its most common clinical presentation, epidemiology, clinical and histological subtypes, with updated diagnostic criteria. To show the different patterns of autoimmune pancreatitis: diffuse,...
Developments in Farm to Retail Price Spreads for Food Products in 1980
Creators: name: Dunham, Denis
name: Dunham, Denis
Publisher: name: Unknown
Year: 1993
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Retail food prices
subject: Farm value
subject: Farm to retail price spread
subject: Food marketing costs
subject: Food retailing
subject: Margins
subject: Profit
subject: Productivity

description: The rise in food prices in 1980 was the smallest in 3 years and well below the inflation rate for all prices in the economy. For domestically produced foods, both the farm value and food-industry charges for processing and marketing rose less than in 1979, limiting the retail price rise. However, retail prices for fish and imported foods, particularly sugar, rose more sharply. The farm to retail price spread rose more than the farm value of foods and was the principal contributor to the increase in food prices. As in past years, about a third of consumer expenditures for domestically produced foods paid for the farm value of foods and the rest was needed to pay for the marketing bill.
La spesa pubblica per l’innovazione nelle politiche di sviluppo rurale per uno sviluppo sostenibile dei sistemi produttivi territoriali
Creators: name: Ascione, Elisa
Publisher: name: Italian Review of Agricultural Economics
Year: 2017

description: This paper analyzes how the rural development policy supports innovation, according to Europe 2020 strategy. Using the information of the Italian FADN 2010-2014, the study analyzes the productivity ratio between large and small farms to measure the gap of their economic performance. The productivity ratio is compared, at regional level, with the consumption of soil for environmental factor and the number of agricultural workers employed for social dimension. The three indicators are compared with public spending for innovation allocated in regional RDPs 2007-2013 and 2014-2020. The results show a weak correlation of public spending with the indicators. Large values of the productivity gap affect negatively on the corresponding values of land use and agricultural employment.
description: Italian Review of Agricultural Economics, Vol 71 No 3 (2016)
A critical reflection on the recent developments in voluntary corporate non-financial and sustainability reporting and disclosure: Lessons learnt from research on integrated reporting adoption in practice
Creators: name: Pigatto, Giacomo
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: This thesis is a critical reflection motivated by the recent developments occurring in the research on voluntary corporate non-financial and sustainability reporting and disclosure (VCnFSRD). This acronym binds together four issues that underlie the research. First, it focusses on information that is voluntarily provided by corporations to interested stakeholders. Therefore, what has been deliberately left out is analyses of any regulations that mandate disclosures, such as Directive2014/95/EU (European Parliament & Council of the European Union, 2014). Second, the reference to corporations is also deliberate. The focus here is not simply on organisations but rather on firms–either for-profit or not-for-profit–that present a corporate structure. Third, information beyond sustainability information is considered, including other types of non-financial information such as intellectual capital (Petty & Guthrie, 2000). Lastly, the distinction between reporting and disclosure is relevant here (Dumay, 2016; Dumay & Guthrie, 2017; La Torre, Sabelfeld, Blomkvist, & Dumay,2020). Reporting has to do with corporations providing periodic accounts of their activities to interested stakeholders (Buhr, Gray, & Milne, 2014; Dumay, 2016), whereas disclosure occurs when unknown or secret information is voluntarily made public by a corporation or involuntarily uncovered by other actors (Dumay & Guthrie, 2017; La Torre et al., 2020). Both are considered in this thesis.
Discussione su “Impresa e non impresa nell’agricoltura italiana. Una analisi sui dati del Censi-mento dell’Agricoltura 2010” di Andrea Arzeni e Franco Sotte
Creators: name: Bacarella, Antonino
name: Prestamburgo, Mario
Publisher: name: Italian Review of Agricultural Economics
Year: 2017

description: The deep structural and functional changes occurred over time in the context of Italian agriculture have significantly changed the farms’ operating processes, taking them to identify and practise new productive and commercial strategies. The clear identification of the farm and the enterprise which derives from it remains a relevant matter connected with the construction of public policies interested in the development and enhancement of the production of goods and services in agriculture. The Authors suggest a critical analysis of the paper by Arzeni and Sotte, 2013. The discussion highlights the distinction between farms and not-farms through a reading of agricultural census data (6th Italian Agriculture General Census 2010).
description: Italian Review of Agricultural Economics, Vol 71 No 3 (2016)
title: High Risk Histological Lesions (B3a and B3b)
Creators: name: Vargas Diaz, Ana Maria
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Biopsy
subject: Vacuum assisted biopsy
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To identify the different histological entities comprised within these groups. To describe the probable differential diagnoses. To make an assessment of the clinical and radiological management of these...
Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.
Creators: name: Caplow, Michael
name: Shanks, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Evidence that 13 or 14 contiguous tubulin-GTP subunits are sufficient to cap and stabilize a microtubule end and that loss of only one of these subunits results in the transition to rapid disassembly(catastrophe) was obtained using the slowly hydrolyzable GTP analogue guanylyl-(a,b)-methylene-diphosphonate (GMPCPP). The minus end of microtubules assembled with GTP was transiently stabilized against dilution-induced disassembly by reaction with tubulin-GMPCPP subunits for a time sufficient to cap the end with an average 40 subunits. The minimum size of a tubulin-GMPCPP cap sufficient to prevent disassembly was estimated from an observed 25- to 2000-s lifetime of the GMPCPP-stabilized microtubules following dilution with buffer and from the time required for loss of a single tubulin-GMPCPP subunit from the microtubule end (found to be 15 s). Rather than assuming that the 25- to 2000-s dispersion in cap lifetime results from an unlikely 80-fold range in the number of tubulin-GMPCpP subunits added in the 25-s incubation, it is proposed that this results because the minimum stable cap contains 13 to 14 tubulin-GMPCPP subunits. As a consequence, a microtubule capped with 13-14 tubulin-GMPCPP subunits switches to disassembly after only one dissociation event (in about 15 s), whereas the time required for catastrophe of a microtubule with only six times as many subunits (84 subunits) corresponds to 71 dissociation events (84-13). The minimum size of a tubulin-GMPCPP cap sufficient to prevent disassembly was also estimated with microtubules in which a GMPCPP-cap was formed by allowing chance to result in the accumulation of multiple contiguous tubulin-GMPCPP subunits at the end, during the disassembly of microtubules containing both GDP and GMPCPP. Our observation that the disassembly rate was inhibited in proportion to the 13-14th power of the fraction of subunits containing GMPCPP again suggests that a minimum cap contains 13-14 tubulin-GMPCPP subunits. A remeasurement of the rate constant for dissociation of a tubulin-GMPCPP subunit from the plus-end of GMPCPP microtubules, now found to be 0.118 s-1, has allowed a better estimate of the standard free energy for hydrolysis of GMPCPP in a microtubule and release of Pi: this is +0.7 kcal/mol, rather than -0.9 kcal/mol, as previously reported.
ms_se_si from Evolution of conditional cooperation in collective-risk social dilemma with repeated group interactions
Creators: name: Hua, Shijia
name: Hui, Zitong
name: Liu, Linjie
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Computational Biology
subject: Biological Mathematics

description: Supplementary material
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
Creators: name: Gilmore, Andrew P.
name: Romer, Lewis H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: It has been proposed that the focal adhesion kinase (FAK) mediates focal adhesion formation through tyrosine phosphorylation during cell adhesion. We investigated the role of FAK in focal adhesion structure and function. Loading cells with a glutathione-S-transferase fusion protein (GST-Cterm) containing the FAK focal adhesion targeting sequence, but not the kinase domain, decreased the association of endogenous FAK with focal adhesions. This displacement of endogenous FAK in both BALB/c 3T3 cells and human umbilical vein endothelial cells loaded with GST-Cterm decreased focal adhesion phosphotyrosine content. Neither cell type, however, exhibited a reduction in focal adhesions after GST-Cterm loading. These results indicate that FAK mediates adhesion-associated tyrosine phosphorylation, but not the formation of focal adhesions. We then examined the effect of inhibiting FAK function on other adhesion-dependent cell behavior. Cells microinjected with GST-Cterm exhibited decreased migration. In addition, cells injected with GST-Cterm had decreased DNA synthesis compared with control-injected or noninjected cells. These findings suggest that FAK functions in the regulation of cell migration and cell proliferation.
Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.
Creators: name: Nucifora Jr., Frederick C.
name: Milgram, Sharon L.
name: Sharp, Alan H.
name: Ross, Christopher A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular calcium channel involved in coupling cell membrane receptors to calcium signal transduction pathways within cells including endocrine cells. Several isoforms (I, II, and III) of IP3Rs have been identified, which are encoded by separate genes, and are expressed in many tissues with differing patterns of cellular expression. We have generated specific affinity-purified polyclonal anti-peptide antibodies to each of the three isoforms. Western blot analysis of RINm5F and ATt20 cells shows high levels of endogenously expressed type I and type III IP3R, but undetectable levels of type II. Immunofluorescence studies revealed an endoplasmic reticulum-like pattern similar to BiP, an ER marker. In contrast with previous claims, both type I and type III IP3Rs were absent from the secretory granules of ATt20 cells. Western blots of sucrose gradients and gel filtration probed with antibodies to either type I or type III showed a molecular weight of greater than 1,000 kDa consistent with a tetrameric structure. Co-immunoprecipitation experiments indicated that most of the receptors were present as heterotetramers. Homotetramers were identified for the type III IP3R; however, type I homotetramers were undetectable. These data suggest that molecular association of IP3Rs into heterotetrameric forms can contribute to the complexity of the regulation of Ca2+ release from ER by IP3Rs within cells.
title: A trainee’s guide to pelvic emergencies in the ED
Creators: name: Barcan, Stefana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Pelvis
subject: CT
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe a brief presentation of the pelvic anatomy To illustrate and discuss different multimodality imaging appearances (ultrasonography, Computed Tomography, Magnetic Resonance Imaging) of variety of acute pelvic pathologies in both genders...
High Energy Collisions of Black Holes Numerically Revisited
Creators: name: Healy, James
name: Ruchlin, Ian
name: Lousto, Carlos O.
name: Zlochower, Yosef
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use fully nonlinear numerical relativity techniques to study high energy head-on collision of nonspinning, equal-mass black holes to estimate the maximum gravitational radiation emitted by these systems. Our simulations include improvements in the construction of initial data, subsequent full numerical evolutions, and the computation of waveforms at infinity. The new initial data significantly reduces the spurious radiation content, allowing for initial speeds much closer to the speed of light, i.e. $v\sim0.99c$. Using these new techniques, We estimate the maximum radiated energy from head-on collisions to be $E_{\text{max}}/M_{\text{ADM}}=0.13\pm0.01$. This value differs from the second-order perturbative $(0.164)$ and zero-frequency-limit $(0.17)$ analytic computations, but is close to those obtained by thermodynamic arguments $(0.134)$ and by previous numerical estimates $(0.14\pm0.03)$.
description: 11 pages, 10 figures
Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.
Creators: name: Amberg, David C.
name: Botstein, David
name: Zahner, Joseph E.
name: Pringle, John R.
name: Mulholland, Jon W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: A search for Saccharomyces cerevisiae proteins that interact with actin in the two-hybrid system and a screen for mutants that affect the bipolar budding pattern identified the same gene, AIP3/BUD6. This gene is not essential for mitotic growth but is necessary for normal morphogenesis. MATa/alpha daughter cells lacking Aip3p place their first buds normally at their distal poles but choose random sites for budding in subsequent cell cycles. This suggests that actin and associated proteins are involved in placing the bipolar positional marker at the division site but not at the distal tip of the daughter cell. In addition, although aip3 mutant cells are not obviously defective in the initial polarization of the cytoskeleton at the time of bud emergence, they appear to lose cytoskeletal polarity as the bud enlarges, resulting in the formation of cells that are larger and rounder than normal. aip3 mutant cells also show inefficient nuclear migration and nuclear division, defects in the organization of the secretory system, and abnormal septation, all defects that presumably reflect the involvement of Aip3p in the organization and/or function of the actin cytoskeleton. The sequence of Aip3p is novel but contains a predicted coiled-coil domain near its C terminus that may mediate the observed homo-oligomerization of the protein. Aip3p shows a distinctive localization pattern that correlates well with its likely sites of action: it appears at the presumptive bud site prior to bud emergence, remains near the tips of small bund, and forms a ring (or pair of rings) in the mother-bud neck that is detectable early in the cell cycle but becomes more prominent prior to cytokinesis. Surprisingly, the localization of Aip3p does not appear to require either polarized actin or the septin proteins of the neck filaments.
title: Volume features on MRI predict tumour grade and survival in progressive IDH-mutant astrocytoma
Creators: name: Smits, Marion
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: Segmentation
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: After initial surgery, astrocytoma eventually progress indicating a change in behaviour, unpredictably affecting patient outcome. The GLASS-NL project (KWF-11026) was initiated to study the longitudinal behavior of low-grade IDH-mutant astrocytoma...
(401642) William Aitken
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
L’efficienza dell’agricoltura regionale italiana e le sue determinanti
Creators: name: Tornese, Tommaso
Publisher: name: Italian Review of Agricultural Economics
Year: 2017

description: This paper offers an efficiency analysis of the regional agriculture sectors in Italy. Applying both parametric and non parametric approach for frontier models to regional level data, the article measures the productivity of regional sectors and investigates the causes of production efficiency. I find that many southern regions have recovered the disadvantage compared to the northern regions during the period analyzed. Furthermore, the work shows that regions with larger firms reach better results, and a more intensive use of organic fertilizer and renewable resources is associated with higher productivity. The models estimated also point out that greater attention to specific education and innovation can improve efficiency.
description: Italian Review of Agricultural Economics, Vol 71 No 3 (2016)
IMPATTO DELLA DEPRESSIONE SUL RISCHIO DI PROGRESSIONE DEL MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER
Creators: name: FUSARI IMPERATORI, SUSANNA MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: The depression symptoms in the elderly may accompany mild cognitive impairment. The aim of this study was to evaluate the role of depression on the risk of evolving to Alzheimer disease (AD) among mild cognitive impairment (MCI) subjects. We present the results of a clinical study of 169 MCI. Diagnosis of depression was based on clinical criteria. The endpoint was development of AD. Result: 81 MCI subjetcs conversion in AD, MCI depressed subjects had reduced risck of conversion.
Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells
Creators: name: Kinch, Michael S.
name: Burridge, Keith
name: Zhong, Cuiling
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic morphology with decreased cell–cell junctions but increased focal adhesions and stress fibers. We have investigated whether the transformed phenotype is due to Rho activation. The Ras-transformed MCF10A cells have elevated levels of myosin light chain phosphorylation and are more contractile than their normal counterparts, consistent with the activation of Rho. Furthermore, inhibitors of contractility restore a more normal epithelial phenotype to the Ras-transformed MCF10A cells. However, inhibiting Rho by microinjection of C3 exotransferase or dominant negative RhoA only partially restores the normal phenotype, in that it fails to restore normal junctional organization. This result prompted us to examine the effect that inhibiting Rho would have on the junctions of normal MCF10A cells. We have found that inhibiting Rho by C3 microinjection leads to a disruption of E-cadherin cytoskeletal links in adherens junctions and blocks the assembly of new adherens junctions. The introduction of constitutively active Rho into normal MCF10A cells did not mimic the Ras-transformed phenotype. Thus, these results lead us to conclude that some, but not all, characteristics of Ras-transformed epithelial cells are due to activated Rho. Whereas Rho is needed for the assembly of adherens junctions, high levels of activated Rho in Ras-transformed cells contribute to their altered cytoskeletal organization. However, additional events triggered by Ras must also be required for the disruption of adherens junctions and the full development of the transformed epithelial phenotype.
(401638) James Coy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.
Creators: name: Briley, Glenn P.
name: Chiu, Marie L.
name: Lee, David C.
name: Andrew Hissong, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Soluble forms of transforming growth factor-alpha (TGF alpha) are derived by proteolytic processing of an integral membrane glycoprotein precursor (pro TGF alpha). Previous studies indicated that phorbol ester-induced cleavage of pro TGF alpha in CHO cells is dependent on the presence of a valine residue located at the carboxyl terminus of the precursor's cytoplasmic domain. We reassessed this requirement with epitope-tagged constructs introduced into transformed rat liver epithelial cells that normally express and process TGF alpha. We found that pro TGF alpha mutants lacking the terminal valine residues showed greatly reduced maturation to the fully glycosylated form. Additionally, they were present at substantially reduced levels on the cell surface and, instead, accumulated in the endoplasmic reticulum. Consistent with these results, enzyme-linked immunosorbent assay (ELISA) and Western blot analyses revealed little or no soluble TGF alpha in medium conditioned by cells expressing the mutant constructs. Finally, a truncated pro TGF alpha mutant lacking most of the cytoplasmic domain but retaining a carboxyl-terminal valine was processed and cleaved in a near-normal manner. These results, some of which were reproduced in CHO cells, indicate that the predominant effect of the carboxyl-terminal valines is to ensure normal maturation and routing of the precursor.
Discovery and spectroscopy of the young Jovian planet 51 Eri b with the Gemini Planet Imager
Creators: name: Macintosh, B.
name: Graham, J. R.
name: Barman, T.
name: De Rosa, R. J.
name: Konopacky, Q.
name: Marley, M. S.
name: Marois, C.
name: Nielsen, E. L.
name: Pueyo, L.
name: Rajan, A.
name: Rameau, J.
name: Saumon, D.
name: Wang, J. J.
name: Patience, J.
name: Ammons, M.
name: Arriaga, P.
name: Artigau, E.
name: Beckwith, S.
name: Brewster, J.
name: Bruzzone, S.
name: Bulger, J.
name: Burningham, B.
name: Burrows, A. S.
name: Chen, C.
name: Chiang, E.
name: Chilcote, J. K.
name: Dawson, R. I.
name: Dong, R.
name: Doyon, R.
name: Draper, Z. H.
name: Duchêne, G.
name: Esposito, T. M.
name: Fabrycky, D.
name: Fitzgerald, M. P.
name: Follette, K. B.
name: Fortney, J. J.
name: Gerard, B.
name: Goodsell, S.
name: Greenbaum, A. Z.
name: Hibon, P.
name: Hinkley, S.
name: Cotten, T. H.
name: Hung, L. -W.
name: Ingraham, P.
name: Johnson-Groh, M.
name: Kalas, P.
name: Lafreniere, D.
name: Larkin, J. E.
name: Lee, J.
name: Line, M.
name: Long, D.
name: Maire, J.
name: Marchis, F.
name: Matthews, B. C.
name: Max, C. E.
name: Metchev, S.
name: Millar-Blanchaer, M. A.
name: Mittal, T.
name: Morley, C. V.
name: Morzinski, K. M.
name: Murray-Clay, R.
name: Oppenheimer, R.
name: Palmer, D. W.
name: Patel, R.
name: Perrin, M. D.
name: Poyneer, L. A.
name: Rafikov, R. R.
name: Rantakyrö, F. T.
name: Rice, E. L.
name: Rojo, P.
name: Rudy, A. R.
name: Ruffio, J. -B.
name: Ruiz, M. T.
name: Sadakuni, N.
name: Saddlemyer, L.
name: Salama, M.
name: Savransky, D.
name: Schneider, A. C.
name: Sivaramakrishnan, A.
name: Song, I.
name: Soummer, R.
name: Thomas, S.
name: Vasisht, G.
name: Wallace, J. K.
name: Ward-Duong, K.
name: Wiktorowicz, S. J.
name: Wolff, S. G.
name: Zuckerman, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Directly detecting thermal emission from young extrasolar planets allows measurement of their atmospheric composition and luminosity, which is influenced by their formation mechanism. Using the Gemini Planet Imager, we discovered a planet orbiting the \$sim$20 Myr-old star 51 Eridani at a projected separation of 13 astronomical units. Near-infrared observations show a spectrum with strong methane and water vapor absorption. Modeling of the spectra and photometry yields a luminosity of L/LS=1.6-4.0 x 10-6 and an effective temperature of 600-750 K. For this age and luminosity, "hot-start" formation models indicate a mass twice that of Jupiter. This planet also has a sufficiently low luminosity to be consistent with the "cold- start" core accretion process that may have formed Jupiter.
description: 29 pages, 3 figures, 2 tables, and Supplementary Materials. published in Science Express on Aug 13 2015. List of authors and the magnitudes of the star were correted
Chemotactic Peptide-induced Changes of Intermediate Filament Organization in Neutrophils during Granule Secretion: Role of Cyclic Guanosine Monophosphate
Creators: name: Pryzwansky, Katherine B.
name: Merricks, Elizabeth P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: In neutrophils activated to secrete with formyl-methionyl-leucyl-phenylalanine, intermediate filaments are phosphorylated transiently by cyclic guanosine monophosphate (cGMP)-dependent protein kinase (G-kinase). cGMP regulation of vimentin organization was investigated. During granule secretion, cGMP levels were elevated and intermediate filaments were transiently assembled at the pericortex to areas devoid of granules and microfilaments. Microtubule and microfilament inhibitors affected intermediate filament organization, granule secretion, and cGMP levels. Cytochalasin D and nocodazole caused intermediate filaments to assemble at the nucleus, rather than at the pericortex. cGMP levels were elevated in neutrophils by both inhibitors; however, with cytochalasin D, cGMP was elevated earlier and granule secretion was excessive. Nocodazole did not affect normal cGMP elevations, but specific granule secretion was delayed. LY83583, a guanylyl cyclase antagonist, inhibited granule secretion and intermediate filament organization, but not microtubule or microfilament organization. Intermediate filament assembly at the pericortex and secretion were partially restored by 8-bromo-cGMP in LY83583-treated neutrophils, suggesting that cGMP regulates these functions. G-kinase directly induced intermediate filament assembly in situ, and protein phosphatase 1 disassembled filaments. However, in intact cells stimulated with formyl-methionyl-leucyl-phenylalanine, intermediate filament assembly is focal and transient, suggesting that vimentin phosphorylation is compartmentalized. We propose that, in addition to changes in microfilament and microtubule organization, granule secretion is also accompanied by changes in intermediate filament organization, and that cGMP regulates vimentin filament organization via activation of G-kinase.
Field theory and weak Euler-Lagrange equation for classical particle-field systems
Creators: name: Qin, Hong
name: Burby, J. W.
name: Davidson, Ronald C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Mathematical Physics (math-ph)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry.
description: 18 pages
title: The many faces of Budd-Chiari syndrome: a pictorial essay
Creators: name: SAKHY, YOUSSEF
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Liver
subject: Vascular
subject: Veins / Vena cava
subject: CT
subject: MR-Angiography
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Education
subject: Embolism / Thrombosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Budd-Chiari syndrome (BCS) is a clinical condition resulting from impaired hepatic venous drainage, in which there is an obstruction to the hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava...
DRUG REPURPOSING FOR THE TREATMENT OF ACUTE MYELOID LEUKAEMIA WITH ADVERSE PROGNOSIS
Creators: name: VALLI, DEBORA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Acute myeloid leukaemia (AML) is a group of aggressive haematopoietic malignancies associated with adverse outcome. Fms-like tyrosine kinase 3 (FLT3) receptor mutations confer a particularly poor prognosis to AML patients. There is no satisfactory treatment against this disease, especially for the cases harbouring FLT3 mutations, and the quest for novel therapeutic options continues. Drug repurposing represents a powerful strategy to single out existing agents active in novel therapeutic contexts. We performed a high-throughput drug screening, designed to search for agents that inhibit the growth of AML cell lines with mutated FLT3 within libraries of FDA-approved compounds or molecules in advanced phases of clinical trials. Auranofin, an antirheumatic drug, and pyrvinium pamoate, an anthelmintic agent, were identified and chosen from the list of 290 hits for in vitro and in vivo validation. We confirmed that in vitro treatment with auranofin and pyrvinium pamoate reduces AML cell growth through a cytotoxic and cytostatic effect, respectively. We identified the synergies/additivities of the two molecules with standard anti-AML drugs (e.g., cytarabine, doxorubicine) and a specific FLT3 inhibitor (quizartinib). Auranofin synergised with cytarabine and its effect was additive when combined with quizartinib; pyrvinium pamoate showed an additive effect when used with doxorubicin and quizartinib. Next, we determined that both auranofin and pyrvinium pamoate act through their described mechanism of action, i.e., inhibit thioredoxin reductase (auranofin) and Wnt signalling (pyrvinium pamoate). In addition, we identified a novel mechanism of action for the two agents: the induction of the endoplasmic reticulum stress and the unfolded protein response that follows. Our results support the potential of auranofin (less so in the case of pyrvinium pamoate) for the treatment of AML patients, including those with FLT3 mutations, provided that the ongoing in vivo validation is successful.
Integrin-mediated Signaling Events in Human Endothelial Cells
Creators: name: Short, Sarah M.
name: Juliano, Rudolph L.
name: Talbott, Gregory A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Vascular endothelial cells are important in a variety of physiological and pathophysiological processes. The growth and functions of vascular endothelial cells are regulated both by soluble mitogenic and differentiation factors and by interactions with the extracellular matrix; however, relatively little is known about the role of the matrix. In the present study, we investigate whether integrin-mediated anchorage to a substratum coated with the extracellular matrix protein fibronectin regulates growth factor signaling events in human endothelial cells. We show that cell adhesion to fibronectin and growth factor stimulation trigger distinct initial tyrosine phosphorylation events in endothelial cells. Thus, integrin-dependent adhesion of endothelial cells leads to tyrosine phosphorylation of both focal adhesion kinase and paxillin, but not of several growth factor receptors. Conversely, EGF stimulation causes receptor autophosphorylation, with no effect on focal adhesion kinase or paxillin tyrosine phosphorylation. Adhesion to fibronectin, in the absence of growth factors, leads to activation of MAPK. In addition, adhesion to fibronectin also potentiates growth factor signaling to MAPK. Thus, polypeptide growth factor activation of MAPK in anchored cells is far more effective than in cells maintained in suspension. Other agonists known to activate MAPK were also examined for their ability to activate MAPK in an anchorage-dependent manner. The neuropeptide bombesin, the bioactive lipid lysophosphatidic acid (LPA), and the cytokine tumor necrosis factor α, which signal through diverse mechanisms, were all able to activate MAPK to a much greater degree in fibronectin-adherent cells than in suspended cells. In addition, tumor necrosis factor α activation of c-Jun kinase (JNK) was also much more robust in anchored cells. Together, these data suggest a cooperation between integrins and soluble mitogens in efficient propagation of signals to downstream kinases. This cooperation may contribute to anchorage dependence of mitogenic cell cycle progression.
Jordan property for non-linear algebraic groups and projective varieties
Creators: name: Meng, Sheng
name: Zhang, De-Qi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 14J50, 32M05

description: A century ago, Camille Jordan proved that the complex general linear group $GL_n(C)$ has the Jordan property: there is a Jordan constant $C_n$ such that every finite subgroup $H \le GL_n(C)$ has an abelian subgroup $H_1$ of index $[H : H_1] \le C_n$. We show that every connected algebraic group $G$ (which is not necessarily linear) has the Jordan property with the Jordan constant depending only on $\dim \, G$, and that the full automorphism group $Aut(X)$ of every projective variety $X$ has the Jordan property
description: American Journal of Mathematics (to appear); minor changes
Microtubules and Microscopes: How the Development of Light Microscopic Imaging Technologies Has Contributed to Discoveries about Microtubule Dynamics in Living Cells
Creators: name: Waterman-Storer, Clare M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Microtubules are dynamic components of the cell cytoskeleton that participate in many important cellular processes, including mitosis, cell motility, morphogenesis, and organelle transport (reviewed in Desai and Mitchison, 1997 ). Microtubules are made up of α/β-tubulin heterodimers that assemble into ∼25 nm cylindrical polymers. Immunofluorescent localization of tubulin has shown that microtubules in interphase tissue cells are for the most part arranged in a radial array with the “minus” end oriented toward a central microtubule organizing center, the centrosome, and the “plus” end radiating toward the cell periphery. Biochemical studies in the 1970s and early 1980s on the assembly–disassembly dynamics of tubulin culminated in the demonstration that microtubules exhibit an unusual form of assembly behavior known as dynamic instability, defined as the coexistence of microtubules in growing and shrinking populations that interconvert infrequently and stochastically (reviewed in Waterman-Storer and Salmon, 1997a ). However, corroboration of these studies with real-time microscopic data was difficult, because 25-nm microtubules are ∼10 times below the resolution limit of the light microscope.
(401639) George Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: US evaluation of benign and malignant axillary pathologies and their main findings.
Creators: name: Perez Lázaro, Raquel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Lymph nodes
subject: Oncology
subject: Ultrasound
subject: Diagnostic procedure
subject: Infection
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Review of axillary anatomy and the ultrasound findings in the normal axilla. Review the main benign diseases and malignant pathologies that cause axillary adenopathies and describe their fundamental ultrasound...
Les compos� nominaux � premier membre pr�positionnel en grec ancien. Le cas de ev�
Creators: name: CARDELLA, MARIA MARGHERITA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: This thesis deals with ancient Greek nominal compounds with a prepositional first member (FM), and in particular the case of the FM ??�. I analyse a great amount of words from a morphological and semantical point of view. The pool of words is based on a formal criterion; the goal of the analysis is to outline different processes of compound formation, as well as their evolution. As compared to other compounds, those with a prepositional FM present two special characteristics: first, they are not formed by two lexemes, since prepositions/adverbs are not real lexemes; secondly, their internal structure is not often recognizable. The guide-questions of this research are: does the special nature of prepositional FM compounds change over different diachronic and diaphasic varieties? Moreover, which are the values of the FM ??� in the different compound categories? Most of the thesis consists in a thorough analysis of compounds attested in three consecutive synchronic phases: first, in archaic epic poetry, then in classical prose of V-IV century (in particular Plato?s and Aristotle?s works); the third part examines all neo-formations appearing in the long period starting from the age of Theophrastus till the age of Nonnus of Panopolis. A brief fourth part presents compounds attested in Arcadian inscriptions, as well as some anthroponyms. In the conclusions, I point out the changes in the value of the FM ??� in the different categories: ??� takes on several functions, that, however, share the signs of a progressive loss of meaning.
title: Update on radiological imaging and nuclear medicine techniques for the diagnosis and monitoring of peritoneal carcinomatosis in ovarian cancer
Creators: name: CERON, LAURA
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Nuclear medicine
subject: Oncology
subject: CT
subject: MR-Diffusion/Perfusion
subject: PET-CT
subject: Diagnostic procedure
subject: Cancer
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To assess the diagnostic accuracy of fluorodeoxyglucose-18 PET-CT and diffusion-weighted MRI (DWI-MRI) for prediction of peritoneal spread in women with ovarian cancer. To evaluate the usefulness of functional techniques for monitoring response to...
title: Review of Zinner`s Syndrome and the role of radiologist in the management of it.
Creators: name: Giménez Hernández, Guillermo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system male
subject: MR
subject: Education
subject: Developmental disease

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The purpose of this poster is to raise awareness about a rare urogenital syndrome since it is the radiologist who normally establishes the diagnosis and has a pivotal role in the management of this entity. We review the state of art of this syndrome...
Exciton-polaritons in van der Waals heterostructures embedded in tunable microcavities
Creators: name: Dufferwiel, S.
name: Schwarz, S.
name: Withers, F.
name: Trichet, A. A. P.
name: Li, F.
name: Sich, M.
name: Del Pozo-Zamudio, O.
name: Clark, C.
name: Nalitov, A.
name: Solnyshkov, D. D.
name: Malpuech, G.
name: Novoselov, K. S.
name: Smith, J. M.
name: Skolnick, M. S.
name: Krizhanovskii, D. N.
name: Tartakovskii, A. I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Layered materials can be assembled vertically to fabricate a new class of van der Waals (VDW) heterostructures a few atomic layers thick, compatible with a wide range of substrates and optoelectronic device geometries, enabling new strategies for control of light-matter coupling. Here, we incorporate molybdenum diselenide/boron nitride (MoSe$_2$/hBN) quantum wells (QWs) in a tunable optical microcavity. Part-light-part-matter polariton eigenstates are observed as a result of the strong coupling between MoSe$_2$ excitons and cavity photons, evidenced from a clear anticrossing between the neutral exciton and the cavity modes with a splitting of 20 meV for a single MoSe$_2$ monolayer QW, enhanced to 29 meV in MoSe$_2$/hBN/MoSe$_2$ double-QWs. The splitting at resonance provides an estimate of the exciton radiative lifetime of 0.4 ps. Our results pave the way for room temperature polaritonic devices based on multiple-QW VDW heterostructures, where polariton condensation and electrical polariton injection through the incorporation of graphene contacts may be realised.
title: Malignant vaginal lesions, what MRI provides to improve multidisciplinary / oncological management
Creators: name: Durany Lara, David
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Pelvis
subject: Urinary Tract / Bladder
subject: MR
subject: PET-CT
subject: Diagnostic procedure
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Our purpose is to demonstrate how important is pelvic MR to assess vaginal malignancies and how helpful can be in multidisciplinary - oncological...