cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Read online: Les clés du cancer
Creators: name: Cheney
Publisher: name: Zenodo
Year: 2024

description: Les clés du cancer pan Laurent Schwartz

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Les clés du cancer

Laurent Schwartz

Nb. de pages: 125

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782365495806

Editeur: Thierry Souccar

Date de parution: 2022

 

 

 

Livre d'ordinateur gratuit à télécharger Les clés du cancer in French 9782365495806

 

Overview

Il faut traiter le cancer comme une maladie métabolique Une percée historique vient d'être faite dans la compréhension du cancer et des moyens de le traiter. Avant d'être perçue comme une maladie du génome, le cancer était considéré comme une maladie du métabolisme : depuis 1924, nous savons que les cellules cancéreuses tirent leur énergie de la fermentation du sucre. Cette piste a été oubliée. Le Dr Schwartz et l'équipe scienti?que pluridisciplinaire qu'il a constituée, l'ont rouverte et explorée. S'appuyant sur les travaux d'illustres prix Nobel de médecine comme Otto Warburg ou Albert Szent-György, ces nouveaux acteurs de la cancérologie - physiciens, mathématiciens, biologistes, médecins - sont parvenus à une nouvelle lecture du cancer, qui ouvre la voie à de nouveaux traitements. Le métabolisme des cellules cancéreuses est perturbé, il faut donc le normaliser et plusieurs substances ont la capacité de le faire, sans effet secondaire majeur. C'est cette révolution qui est la vraie raison de ce livre. Ce premier traitement métabolique a déjà béné?cié à de nombreux malades - plusieurs cas sont rapportés dans l'ouvrage. Complémentaire des traitements conventionnels, cette approche métabolique du cancer est porteuse d'espoir pour les patients et les chercheurs.
Тепломассообменные процессы при длительном хранении зерна пшеницы в металлических силосах
Creators: name: Беляева Марина Александровна
name: Кечкин Иван Александрович
Publisher: name: Пищевая промышленность
Year: 2020
Subjects: длительное хранение
активное вентилирование
металлические силоса
тепломассообменные процессы

description: Были исследованы изменения параметров температуры и влажности (начальное значение 10,6 %) зерна пшеницы в течение года хранения. Влажность зерна как в пристенной, так и центральной частях металлического силоса практически не изменялась, оставаясь на уровне от 10 до 11 %. Значения влажности фиксировали ежемесячно, а температуру зерна, диапазон изменений которой от 20 до 32 °С, при минимальной температуре наружного воздуха минус 5 °С, в соответствии с сезонными изменениями температуры. На основе экспериментальных исследований авторы пришли к выводу, что влажность зерна в поверхностном слое имела тенденцию к увеличению на 0,4–1,2 %, конечная влажность зерна в процессе проведения опытов составляла 11,6 %. Эксперименты по изменению температуры и влажности зерна при активном вентилировании в металлических силосах большой емкости показали, что скорость изменения (понижения) температуры зависит от удельного расхода воздуха, разности температуры воздуха и зерна. Опытное хранение показало, что зерно с влажностью до 13,6 % без ухудшения качества можно хранить до девяти месяцев. Больший срок хранения возможен для зерна пшеницы с влажностью до 12 %. Надзерновое и подкровельное пространство металлических силосов большой емкости непосредственно связаны с одним из существенных факторов потенциально возможного повышения качественной сохранности зерна при его длительном хранении – за счет применения возможных приемов, обеспечивающих снижение эффектов конденсации влаги на внутренних поверхностях кровли и незаполненных стен силоса. Такая конденсация влаги наиболее вероятна в осенне-зимний период, когда хранящееся зерно еще не охлаждено активным вентилированием, а температура наружного воздуха регулярно опускается до значений ниже температуры точки росы для воздуха, находящегося в непосредственном соприкосновении с указанными внутренними поверхностями силоса. Расчеты показали, что условия для такой конденсации возможны уже при перепаде температуры между зерном и наружным воздухом от 5 до 6 °С. Сама же такая возможная конденсация влаги заканчивается ее стеканием на поверхность зерновой массы, что приводит к появлению на поверхностях зерновок свободной влаги и является существенным фактором снижения качественной сохранности зерна при его длительном хранении. В статье уделено особое внимание процессам, протекающим в подкровельном пространстве металлических силосов большой емкости и предложены способы решения данной проблемы.
Impact of the Primordial Stellar Initial Mass Function on the 21-cm Signal
Creators: name: Gessey-Jones, T.
name: Sartorio, N. S.
name: Fialkov, A.
name: Mirouh, G. M.
name: Magg, M.
name: Izzard, R. G.
name: Acedo, E. de Lera
name: Handley, W. J.
name: Barkana, R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Properties of the first generation of stars (Pop III), such as their initial mass function (IMF), are poorly constrained by observations and have yet to converge between simulations. The cosmological 21-cm signal of neutral hydrogen is predicted to be sensitive to Lyman-band photons produced by these stars, thus providing a unique way to probe the first stellar population. In this paper, we investigate the impacts of the Pop III IMF on the cosmic dawn 21-cm signal via the Wouthuysen-Field effect, Lyman-Werner feedback, Ly-alpha heating, and CMB heating. We calculate the emission spectra of star-forming halos for different IMFs by integrating over individual metal-free stellar spectra, computed from a set of stellar evolution histories and stellar atmospheres, and taking into account variability of the spectra with stellar age. Through this study, we therefore relax two common assumptions: that the zero-age main sequence emission rate of a Pop III star is representative of its lifetime mean emission rate, and that Pop III emission can be treated as instantaneous. Exploring a bottom-heavy, a top-heavy, and intermediate IMFs, we show that variations in the 21-cm signal are driven by stars lighter than 20 solar masses. For the explored models we find maximum relative differences of 59% in the cosmic dawn global 21-cm signal, and 131% between power spectra. Although this impact is modest, precise modelling of the first stars and their evolution is necessary for accurate prediction and interpretation of the 21-cm signal.
description: 20 pages, 16 figures. Accepted for publication in MNRAS, updated to accepted version
ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R
Creators: name: Wright, Marvin N.
name: Ziegler, Andreas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: We introduce the C++ application and R package ranger. The software is a fast implementation of random forests for high dimensional data. Ensembles of classification, regression and survival trees are supported. We describe the implementation, provide examples, validate the package with a reference implementation, and compare runtime and memory usage with other implementations. The new software proves to scale best with the number of features, samples, trees, and features tried for splitting. Finally, we show that ranger is the fastest and most memory efficient implementation of random forests to analyze data on the scale of a genome-wide association study.
Computational capability for physical reservoir computing using a spin-torque oscillator with two free layers
Creators: name: Yamaguchi, Terufumi
name: Tsunegi, Sumito
name: Nakajima, Kohei
name: Taniguchi, Tomohiro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: A numerical analysis on the computational capability of physical reservoir computing utilizing a spin-torque oscillator with two free layers is reported. Conventional spintronics devices usually consist of two ferromagnets, where the direction of magnetization in one layer, called the free layer, can move while that of the other, the reference layer, is fixed. Recently, however, devices with two free layers, where the reference layer is replaced by another free layer, have been developed for various practical applications. Adding another free layer drastically changes the dynamical response of the device through the couplings via the spin-transfer effect and the dipole magnetic field. A numerical simulation of the Landau-Lifshitz-Gilbert equation and a statistical analyses of the Lyapunov exponent and the synchronization index reveal the appearance of an amplitude-modulated oscillation and chaos in the oscillators with two free layers. Such complex dynamics qualitatively change the computational capability of physical reservoir computing because the computational resource is dynamics of the physical system. An evaluation of the short-term memory capacity clarifies that oscillators with two free layers have a larger capacity than those of conventional oscillators. An enhancement in capacity near the edge of echo state property, i.e., the boundary between zero and finite synchronization index, is also found.
description: 16 pages, 11 figures
Read [pdf]> Wild Game: My Mother, Her Lover, and Me by Adrienne Brodeur
Creators: name: Rodriguez
Publisher: name: Zenodo
Year: 2024

description: Wild Game: My Mother, Her Lover, and Me by Adrienne Brodeur

 

 

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Wild Game: My Mother, Her Lover, and Me

Adrienne Brodeur

Page: 256

Format: pdf, ePub, mobi, fb2

ISBN: 9781328519030

Publisher: HMH Books

 

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Overview

A daughter’s tale of living in the thrall of her magnetic, complicated mother, and the chilling consequences of her complicity. On a hot July night on Cape Cod when Adrienne was fourteen, her mother, Malabar, woke her at midnight with five simple words that would set the course of both of their lives for years to come: Ben Souther just kissed me.    Adrienne instantly became her mother’s confidante and helpmate, blossoming in the sudden light of her attention, and from then on, Malabar came to rely on her daughter to help orchestrate what would become an epic affair with her husband’s closest friend. The affair would have calamitous consequences for everyone involved, impacting Adrienne’s life in profound ways, driving her into a precarious marriage of her own, and then into a deep depression. Only years later will she find the strength to embrace her life—and her mother—on her own terms.   Wild Game is a brilliant, timeless memoir about how the people close to us can break our hearts simply because they have access to them, and the lies we tell in order to justify the choices we make. It’s a remarkable story of resilience, a reminder that we need not be the parents our parents were to us.
Комплексное исследование состава виски методами газовой хроматографии и капиллярного электрофореза
Creators: name: Шелехова Наталия Викторовна
name: Шелехова Тамара Михайловна
name: Скворцова Любовь Ивановна
name: Полтавская Наталья Валериевна
Publisher: name: Пищевая промышленность
Year: 2020
Subjects: виски
газовая хроматография
идентификация
ионный состав
летучие органические примеси
капиллярный электрофорез

description: В целях совершенствования эффективности работы в сфере контроля и регулирования оборота алкогольной продукции важной задачей является разработка новых методик идентификации химического состава спиртных напитков. Данное на‑ правление исследований обладает высокой значимостью, так как связано со здоровьем населения России, что в полной мере соответствует требованиям «Стратегии повышения качества пищевой продукции в РФ» и новой «Доктрины продоволь‑ ственной безопасности РФ». Цель настоящего исследования – разработка и апробация новых инструментальных методик определения химического состава виски. На основе методов газовой хроматографии и капиллярного электрофореза разра‑ ботаны новые экспрессные методики анализа, отличающиеся простотой, надежностью, высокой точностью. С применени‑ ем разработанных методик исследовано 11 образцов виски производства Ирландии, Шотландии и России. Получены новые экспериментальные данные, свидетельствующие об эффективности применения разработанных методик для определения химического состава виски. Методом газовой хроматографии установлено, что во всех исследованных образцах присут‑ ствуют ацетальдегид, этилацетат, метанол, 1‑пропанол, изобутанол, 1‑бутанол, изоамилол, уксусная кислота. В боль‑ шинстве образцов обнаружены ацетон, этилформиат, 2‑пропанол, изоамилацетат, этиллактат, фурфурол, этилкаприлат, 2‑фенилэтанол. В двух образцах обнаружены 2‑бутанол, 1‑пентанол, этилкапринат. Показано, что массовая концентрация компонентов летучих органических примесей варьирует в широких пределах, общая сумма идентифицированных примесей находится в диапазоне 1236–5737 мг / дм3. Методом капиллярного электрофореза установлено, что во всех исследованных образцах виски присутствуют аммоний, калий, кальций, натрий, магний, суммарное содержание катионов варьирует в диа‑ пазоне 4,6–32,5 мг / дм3. Найдены отличия в составе летучих органических примесей и катионов виски, которые объясняют‑ ся химическими реакциями, происходящими в ходе технологических процессов производства. Определены перспективные направления для дальнейших исследований, позволяющие расширить перечень нормируемых физико-химических показа‑ телей в виски и сформулировать объективные критерии для выявления фальсификаций.
(3210) Paul Reginald Askew
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integration of sparse multi-modality representation and anatomical constraint for isointense infant brain MR image segmentation
Creators: name: Gao, Yaozong
name: Wang, Li
name: Shi, Feng
name: Li, Gang
name: Lin, Weili
name: Shen, Dinggang
name: Gilmore, John H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Segmentation of infant brain MR images is challenging due to poor spatial resolution, severe partial volume effect, and the ongoing maturation and myelination process. During the first year of life, the brain image contrast between white and gray matters undergoes dramatic changes. In particular, the image contrast inverses around 6–8 months of age, where the white and gray matter tissues are isointense in T1 and T2 weighted images and hence exhibit the extremely low tissue contrast, posing significant challenges for automated segmentation. In this paper, we propose a general framework that adopts sparse representation to fuse the multi-modality image information and further incorporate the anatomical constraints for brain tissue segmentation. Specifically, we first derive an initial segmentation from a library of aligned images with ground-truth segmentations by using sparse representation in a patch-based fashion for the multi-modality T1, T2 and FA images. The segmentation result is further iteratively refined by integration of the anatomical constraint. The proposed method was evaluated on 22 infant brain MR images acquired at around 6 months of age by using a leave-one-out cross-validation, as well as other 10 unseen testing subjects. Our method achieved a high accuracy for the Dice ratios that measure the volume overlap between automated and manual segmentations, i.e., 0.889±0.008 for white matter and 0.870±0.006 for gray matter.
Регулирование органолептических показателей и пищевой ценности фаршевых систем из тощих океанических рыб с использованием БАД функционального назначения
Creators: name: Васюкова Анна Тимофеевна
name: Тихонов Дмитрий Анатольевич
name: Тонапетян Тароник Арутюнович
Publisher: name: Пищевая промышленность
Year: 2020
Subjects: формирование
органолептические показатели
фаршевые системы
биологически активные добавки
алифатические соединения

description: Перспективным направлением государственной политики в области здорового питания является создание технологий производства качественно новых пищевых продуктов с направленным изменением химического состава, соответствующим потребностям организма человека. Использование технологических добавок при создании функциональных продуктов актуально. В статье показаны возможности регулирования органолептических показателей фаршевых систем из тощих океанических рыб с использованием жиросодержащих продуктов, вкусо-ароматических добавок, структурообразователей и пищевых БАД функционального назначения. Такое взаимное дополнение рецептуры различными компонентами позволяет создать комбинированный фарш специального назначения и изделия на его основе, наиболее отвечающие потребностям организма по пищевой и биологической ценности. Целью научных исследований являлось регулирование органолептических показателей и пищевой ценности фаршевых систем из тощих океанических рыб с использованием БАД функционального назначения. Введение в рецептуру «Моби люкс Универсал» в качестве биологически активной добавки позволяет обогатить фарш Ca, Fe и I, а также витаминами, пищевыми волокнами и белками. Доказано, что формирование вкусовых характеристик осуществляется за счет образования алифатических соединений, основу которых составляют дии триметиламин (ДМА и ТМА), свободные аминикислоты, спирты. Установлено, что наилучшие варианты сочетания рыбного сырья и добавок 59:2:3. Нетрадиционная вкусовая гамма получена для котлет с «Моби люкс Универсал».
Excitation of gravity waves by fingering convection, and the formation of compositional staircases in stellar interiors
Creators: name: Garaud, P.
name: Medrano, M.
name: Brown, J.
name: Mankovich, C.
name: Moore, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Fingering convection (or thermohaline convection) is a weak yet important kind of mixing that occurs in stably-stratified stellar radiation zones in the presence of an inverse mean-molecular-weight gradient. Brown et al. (2013) recently proposed a new model for mixing by fingering convection, which contains no free parameter, and was found to fit the results of direct numerical simulations in almost all cases. Notably, however, they found that mixing was substantially enhanced above their predicted values in the few cases where large-scale gravity waves, followed by thermo-compositional layering, grew spontaneously from the fingering convection. This effect is well-known in the oceanographic context, and is attributed to the excitation of the so-called "collective instability". In this work, we build on the results of Brown et al. (2013) and of Traxler et al. (2011b) to determine the conditions under which the collective instability may be expected. We find that it is only relevant in stellar regions which have a relatively large Prandtl number (the ratio of the kinematic viscosity to the thermal diffusivity), $O(10^{-3})$ or larger. This implies that the collective instability cannot occur in main sequence stars, where the Prandtl number is always much smaller than this (except in the outer layers of surface convection zones where fingering is irrelevant anyway). It could in principle be excited in regions of high electron degeneracy, during He core flash, or in the interiors of white dwarfs. We discuss the implications of our findings for these objects, both from a theoretical and from an observational point of view.
description: To be published in ApJ
Supplementary figure and data analyses from Modulation frequency as a cue for auditory speed perception
Creators: name: Senna, Irene
name: Parise, Cesare V.
name: Ernst, Marc O.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Unlike vision, the mechanisms underlying auditory motion perception are poorly understood. Here we describe an auditory motion illusion revealing a novel cue to auditory speed perception: the temporal frequency of amplitude modulation (AM-frequency), typical for rattling sounds. Naturally, corrugated objects sliding across each other generate rattling sounds whose AM-frequency tend to directly correlate with speed. We found that AM-frequency modulates auditory speed perception in a highly systematic fashion: moving sounds with higher AM-frequency are perceived as moving faster than sounds with lower AM-frequency. Even more interestingly, sounds with higher AM-frequency also induce stronger motion aftereffects. This reveals the existence of specialized neural mechanisms for auditory motion perception, which are sensitive to AM-frequency. Thus, in spatial hearing, the brain successfully capitalizes on the AM-frequency of rattling sounds to estimate the speed of moving objects. This tightly parallels previous findings in motion vision, where spatio-temporal frequency of moving displays systematically affects both speed perception, and the magnitude of the motion aftereffects. Such an analogy with vision suggests that motion detection may rely on canonical computations, with similar neural mechanisms shared across the different modalities.
On the construction of suitable weak solutions to the 3D Navier-Stokes equations in a bounded domain by an artificial compressibility method
Creators: name: Berselli, Luigi C.
name: Spirito, Stefano
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper we will prove that suitable weak solutions of three dimensional Navier-Stokes equations in bounded domain can be constructed by a particular type of artificial compressibility approximation.
(3208) Harry Hoatson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantitative tract-based white matter heritability in twin neonates
Creators: name: Neale, Michael C.
name: Steiner, Rachel J.
name: Zhu, Hongtu
name: Styner, Martin
name: Gilmore, John H.
name: Luo, Shikai
name: Lee, Seung Jae
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Studies in adults indicate that white matter microstructure, assessed with diffusion tensor imaging (DTI), has high heritability. Little is known about genetic and environmental influences on DTI parameters, measured along fiber tracts particularly, in early childhood. In the present study, we report comprehensive heritability data of white matter microstructure fractional anisotropy (FA), radial diffusion (RD), and axial diffusion (AD) along 47 fiber tracts using the quantitative tractography in a large sample of neonatal twins (n=356). We found significant genetic influences in almost all tracts with similar heritabilities for FA, RD, and AD as well as positive relationships between these parameters and heritability. In a single tract analysis, genetic influences along the length of the tract were highly variable. These findings suggest that at birth, there is marked heterogeneity of genetic influences of white matter microstructure within white matter tracts. This study provides a basis for future studies of developmental changes in genetic and environmental influences during early childhood, a period of rapid development that likely plays a major role in individual differences in white matter structure and function.
The Partner Plot by Kristina Forest on Ipad
Creators: name: Ramsey
Publisher: name: Zenodo
Year: 2024

description: The Partner Plot by Kristina Forest

 

 

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The Partner Plot

Kristina Forest

Page: 416

Format: pdf, ePub, mobi, fb2

ISBN: 9780593546451

Publisher: Penguin Publishing Group

 

Ebook for share market free download The Partner Plot

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Automated Segmentation of Mouse Brain Images Using Multi-Atlas Multi-ROI Deformation and Label Fusion
Creators: name: Shen, Dinggang
name: Nie, Jingxin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We propose an automated multi-atlas and multi-ROI based segmentation method for both skull-stripping of mouse brain and the ROI-labeling of mouse brain structures from the three dimensional (3D) magnetic resonance images (MRI). Three main steps are involved in our method. First, a region of interest (ROI) guided warping algorithm is designed to register multi-atlas images to the subject space, by considering more on the matching of image contents around the ROI boundaries which are more important for ROI labeling. Then, a multi-atlas and multi-ROI based deformable segmentation method is adopted to refine the ROI labeling result by deforming each ROI surface via boundary recognizers (i.e., SVM classifiers) trained on local surface patches. Finally, a local-mutual-information (MI) based multi-label fusion technique is proposed for allowing the atlases with better local image similarity with the subject to have more contributions in label fusion. The experimental results show that our method works better than the conventional methods on both in vitro and in vivo mouse brain datasets.
Supplementary table of mean peak chondrocranium kinematics (Table S1) and figures of XROMM methods (Fig. S1) and chondrocranium kinematics (Fig. S2) from Dual function of the pectoral girdle for feeding and locomotion in white-spotted bamboo sharks.
Creators: name: Camp, Ariel L.
name: Scott, Bradley
name: Brainerd, Elizabeth L.
name: Wilga, Cheryl D.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Supplementary Table 1: Mean (standard error) peak magnitudes of chondrocranium rotations (rot.) in degrees and translations (trans.) in millimeters. Figure S1. Filming methods and X-ray Reconstruction of Moving Morphology (XROMM). Biplanar x-ray videos were filmed obliquely during suction feeding (a). Sample X-ray image of cartilages and markers in one view (b). These images were combined with 3D polygonal models from CT scans (c) to reconstruct the motion of the chondrocranium, palatoquadrate (teal), Meckel's cartilage (blue), ceratohyal (orange), and pectoral girdle. A body plane was calculated from the motion of 3-6 intramuscular markers (red). Figure S2. Kinematics of the chondrocranium, measured relative to the body plane. A joint coordinate system (A) measured motion as rotations (B) and translations (C) about each axis (data in these panels are from a sample strike). (D) Z-axis rotations (i.e., elevation and depression) of the chondrocranium from each strike (blue lines), as well as the mean rotation at each time step (black line), for each individual. Time is calculated relative to the time of peak gape.
A low-mass protostar's disk-envelope interface: disk-shadowing evidence from ALMA DCO+ observations of VLA1623
Creators: name: Murillo, Nadia M.
name: Bruderer, Simon
name: van Dishoeck, Ewine F.
name: Walsh, Catherine
name: Harsono, Daniel
name: Lai, Shih-Ping
name: Fuchs, Christian M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Due to instrumental limitations and a lack of disk detections, the structure between the envelope and the rotationally supported disk has been poorly studied. This is now possible with ALMA through observations of CO isotopologs and tracers of freezeout. Class 0 sources are ideal for such studies given their almost intact envelope and young disk. The structure of the disk-envelope interface of the prototypical Class 0 source, VLA1623A which has a confirmed Keplerian disk, is constrained from ALMA observations of DCO+ 3-2 and C18O 2-1. The physical structure of VLA1623 is obtained from the large-scale SED and continuum radiative transfer. An analytic model using a simple network coupled with radial density and temperature profiles is used as input for a 2D line radiative transfer calculation for comparison with the ALMA Cycle 0 12m array and Cycle 2 ACA observations of VLA1623. DCO+ emission shows a clumpy structure bordering VLA1623A's Keplerian disk, suggesting a cold ring-like structure at the disk-envelope interface. The radial position of the observed DCO+ peak is reproduced in our model only if the region's temperature is between 11-16K, lower than expected from models constrained by continuum and SED. Altering the density has little effect on the DCO+ position, but increased density is needed to reproduce the disk traced in C18O. The DCO+ emission around VLA1623A is the product of shadowing of the envelope by the disk. Disk-shadowing causes a drop in the gas temperature outside of the disk on >200AU scales, encouraging deuterated molecule production. This indicates that the physical structure of the disk-envelope interface differs from the rest of the envelope, highlighting the drastic impact that the disk has on the envelope and temperature structure. The results presented here show that DCO+ is an excellent cold temperature tracer.
description: Accepted for publication in Astronomy & Astrophysics, 16 pages with appendices, 17 figures and 3 tables
[download pdf] Emotifs talentueux  - Etre soi autrement : 6 étapes pour vivre pleinement sont Haut potentiel
Creators: name: Creamer
Publisher: name: Zenodo
Year: 2024

description: Emotifs talentueux - Etre soi autrement : 6 étapes pour vivre pleinement sont Haut potentiel pan Nathalie Alsteen

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Emotifs talentueux - Etre soi autrement : 6 étapes pour vivre pleinement sont Haut potentiel

Nathalie Alsteen

Nb. de pages: 286

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782843194344

Editeur: Josette Lyon

Date de parution: 2019

 

 

 

Livre en anglais gratuit à télécharger Emotifs talentueux - Etre soi autrement : 6 étapes pour vivre pleinement sont Haut potentiel par Nathalie Alsteen 9782843194344 CHM FB2

 

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"Tu es trop sensible, tu réfléchis trop, tu te disperses trop, tu es bizarre, tu ne fais pas comme les autres..." Quand ces messages sont entendus depuis l'enfance, difficile de faire autrement que de se sentir comme un extraterrestre. Le Haut Potentiel génère très souvent un sentiment de décalage et est difficilement vécu lorsque le sentiment de ne pas être à sa place prend le dessus. Comment occuper pleinement sa place et vivre sereinement quand on est hypersensible et Haut Potentiel ? Accueillir le fait d'être surdoué comme un cadeau passe par la découverte de nouveaux repères pour mieux se connaître et déployer son potentiel. Ce livre propose une méthode qui fait ses preuves depuis quinze ans, enrichie de modèles, témoignages et exemples illustrant les différentes étapes proposées comme un voyage vers l'authenticité. Il donne des clés pour faire des choix qui nous correspondent, vivre des relations harmonieuses, trouver le calme intérieur et retrouver son énergie. Le chemin proposé rend possible l'utilisation de sa différence pour contribuer autrement à un monde en recherche de sens.
Erratum: Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A–Receptor Agonist
Creators: name: Overstreet, David H.
name: Breese, George R.
name: Knapp, Darin J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Repeated withdrawals from chronic ethanol sensitize the withdrawal-induced reduction in social interaction behaviors. This study determined whether stress might substitute for repeated withdrawals to facilitate withdrawal-induced anxiety-like behavior. When two 1-h periods of restraint stress were applied at 1-week intervals to rats fed control diet, social interaction was reduced upon withdrawal from a subsequent 5-day exposure to ethanol diet. Neither this ethanol exposure alone nor exposure to three restraint stresses alone altered this measure of anxiety. Further, the repeatedly stressed singly withdrawn rats continued to exhibit a reduction in social interaction 16 days later, upon withdrawal from re-exposure to 5 days of chronic ethanol, consistent with a persistent adaptation by the multiple-stress/withdrawal protocol. Weekly administration of corticosterone in place of stress induced no significant change in social interaction upon withdrawal from the single chronic ethanol exposure, indicative that corticoid release is not responsible for the stress-induced reduction in anxiety-like behavior during withdrawal. In the multiple-withdrawal protocol, stress applied during withdrawal from voluntary ethanol drinking by P-rats facilitated ethanol drinking sufficiently, to induce a withdrawal-induced reduction in social interaction. Administration of a CRF-1 receptor antagonist, a benzodiazepine receptor antagonist, or a 5-HT1A receptor agonist prior to each stress minimized sensitization of the withdrawal-induced reduction in anxiety-like behavior. Since these pharmacological consequences on the induction of anxiety-like behavior following the stress/withdrawal protocol are like those previously seen when these drug treatments were given prior to multiple withdrawals, evidence is provided that repeated stresses and multiple withdrawals sensitize the withdrawal reduction in social interaction by similar central adaptive mechanisms.
Multistability and anomalies in oscillator models of lossy power grids
Creators: name: Delabays, Robin
name: Jafarpour, Saber
name: Bullo, Francesco
Publisher: name: arXiv
Year: 2022
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The analysis of dissipatively coupled oscillators is challenging and highly relevant in power grids. Standard mathematical methods are not applicable, due to the lack of network symmetry induced by dissipative couplings. Here we demonstrate a close correspondence between stable synchronous states in dissipatively coupled oscillators, and the {winding partition} of their state space, a geometric notion induced by the network topology. Leveraging this winding partition, we accompany this article with an algorithms to compute all synchronous solutions of complex networks of dissipatively coupled oscillators. These geometric and computational tools allow us to identify anomalous behaviors of lossy networked systems. Counterintuitively, we show that loop flows and dissipation can increase the system's transfer capacity, and that dissipation can promote multistability. We apply our geometric framework to compute power flows on the IEEE RTS-96 test system, where we identify two high voltage solutions with distinct loop flows.
description: Main text: 14 pages, 5 figures. Supplementary information: 6 pages, 2 figures
[Pdf/ePub] Python for Kids, 2nd Edition: A Playful Introduction to Programming by Jason R. Briggs download ebook
Creators: name: Perkins
Publisher: name: Zenodo
Year: 2024

description: Python for Kids, 2nd Edition: A Playful Introduction to Programming by Jason R. Briggs

 

 

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Python for Kids, 2nd Edition: A Playful Introduction to Programming

Jason R. Briggs

Page: 368

Format: pdf, ePub, mobi, fb2

ISBN: 9781718503021

Publisher: No Starch Press

 

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Обоснование изменения перечня пищевых добавок, разрешенных для использования в Евразийском экономическом союзе
Creators: name: Багрянцева Ольга Викторовна
name: Хотимченко Сергей Анатольевич
name: Елизарова Елена Викторовна
Publisher: name: Пищевая промышленность
Year: 2020
Subjects: пищевые добавки
перечень
законодательство Евразийского экономического союза

description: Основным требованием применения пищевых добавок (ПД) является отсутствие их вредного действия на организм человека в результате длительного поступления с пищей в течение всей жизни человека и даже нескольких поколений. В связи с появлением новых научных данных, развитием технологий производства пищевой продукции существует необходимость внесения изменений в законодательные акты Евразийского экономического союза (ЕАЭС), введение которых будет способствовать обеспечению безопасного применения ПД, а также гармонизации законодательства ЕАЭС с международным законодательством. Решения по возможности применения в пищевой промышленности конкретных ПД принимаются на основании тщательного анализа всех имеющихся в распоряжении экспертов результатов научных исследований, в том числе оценивается канцерогенность, мутагенность и эмбриотоксичность пищевых добавок с учетом рекомендаций Комиссии «Кодекс Алиментариус» и решений Европейского Союза, гарантирующих безопасное использование и технологическую необходимость использования веществ в качестве ПД. В статье приведены обоснования актуализации перечня ПД, разрешенных для использования в пищевой промышленности на территории ЕАЭС.
(3207) Mabel [Hoatson]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Connected and Automated Vehicle Platoon Formation Control via Differential Games
Creators: name: Jond, Hossein B.
name: Yıldız, Aykut
Publisher: name: arXiv
Year: 2022
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this study, the connected and automated vehicles (CAVs) platooning problem is resolved under a differential game framework. Three information topologies are considered here. Firstly, Predecessor-following (PF) topology is utilized where the vehicles control the distance with respect to the merely nearest predecessor via a sensor link-based information flow. Secondly, Two-predecessor-following topology (TPF) is exploited where each vehicle controls the distance with respect to the two nearest predecessors. In this topology, the second predecessor is communicated via a Vehicle-to-vehicle (V2V) link. The individual trajectories of CAVs under the Nash equilibrium are derived in closed-form for these two information topologies. Finally, general information topology is examined and the differential game is formulated in this context. In all these options, Pontryagin's principle is employed to investigate the existence and uniqueness of the Nash equilibrium and obtain its corresponding trajectories. In the general topology, we suppose numerical computation of eigenvalues and eigenvectors. All these approaches represent promising and powerful analytical representations of the CAV platoons under the differential games. Simulation experiments have verified the efficiency of the proposed models and their solutions.
description: This paper has been revised and accepted by IET Intelligent Transport Systems, available fully open access at https://doi.org/10.1049/itr2.12260
Supplementary table of mean peak chondrocranium kinematics (Table S1) and figures of XROMM methods (Fig. S1) and chondrocranium kinematics (Fig. S2) from Dual function of the pectoral girdle for feeding and locomotion in white-spotted bamboo sharks
Creators: name: Camp, Ariel L.
name: Scott, Bradley
name: Brainerd, Elizabeth L.
name: Wilga, Cheryl D.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Supplementary Table 1: Mean (standard error) peak magnitudes of chondrocranium rotations (rot.) in degrees and translations (trans.) in millimeters. Figure S1. Filming methods and X-ray Reconstruction of Moving Morphology (XROMM). Biplanar x-ray videos were filmed obliquely during suction feeding (a). Sample X-ray image of cartilages and markers in one view (b). These images were combined with 3D polygonal models from CT scans (c) to reconstruct the motion of the chondrocranium, palatoquadrate (teal), Meckel's cartilage (blue), ceratohyal (orange), and pectoral girdle. A body plane was calculated from the motion of 3-6 intramuscular markers (red). Figure S2. Kinematics of the chondrocranium, measured relative to the body plane. A joint coordinate system (A) measured motion as rotations (B) and translations (C) about each axis (data in these panels are from a sample strike). (D) Z-axis rotations (i.e., elevation and depression) of the chondrocranium from each strike (blue lines), as well as the mean rotation at each time step (black line), for each individual. Time is calculated relative to the time of peak gape.
Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
Creators: name: Bradford, Daniel W.
name: Leimone, Linda A.
name: Keefe, Richard S.E.
name: Savitz, Adam J.
name: Marx, Christine E.
name: Lieberman, Jeffrey A.
name: Morrow, A. Leslie
name: Porcu, Patrizia
name: Shampine, Lawrence J.
name: Kilts, Jason D.
name: Hamer, Robert M.
name: Naylor, Jennifer C.
name: Strauss, Jennifer L.
name: Dunn, Lawrence
name: Payne, Victoria M.
name: Buchanan, Robert W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia. Furthermore, clozapine increases pregnenolone in rodent hippocampus, possibly contributing to its superior efficacy. We therefore investigated adjunctive pregnenolone for cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder receiving stable doses of second-generation antipsychotics in a pilot randomized, placebo-controlled, double-blind trial. Following a 2-week single-blind placebo lead-in, patients were randomized to pregnenolone (fixed escalating doses to 500 mg/day) or placebo, for 8 weeks. Primary end points were changes in BACS and MCCB composite and total SANS scores. Of 21 patients randomized, 18 completed at least 4 weeks of treatment (n = 9/group). Pregnenolone was well tolerated. Patients receiving pregnenolone demonstrated significantly greater improvements in SANS scores (mean change = 10.38) compared with patients receiving placebo (mean change = 2.33), p = 0.048. Mean composite changes in BACS and MCCB scores were not significantly different in patients randomized to pregnenolone compared with placebo. However, serum pregnenolone increases predicted BACS composite scores at 8 weeks in the pregnenolone group (rs = 0.81, p = 0.022). Increases in allopregnanolone, a GABAergic pregnenolone metabolite, also predicted BACS composite scores (rs = 0.74, p = 0.046). In addition, baseline pregnenolone (rs = −0.76, p = 0.037), pregnenolone sulfate (rs = − 0.83, p = 0.015), and allopregnanolone levels (rs = −0.83, p = 0.015) were inversely correlated with improvements in MCCB composite scores, further supporting a possible role for neurosteroids in cognition. Mean BACS and MCCB composite scores were correlated (rs = 0.74, p <0.0001). Pregnenolone may be a promising therapeutic agent for negative symptoms and merits further investigation for cognitive symptoms in schizophrenia.