Additional file 1 of Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study
Creators: name: Magnus, Maria C.
name: Lee, Yunsung
name: Carlsen, Ellen Ø.
name: Arge, Lise A.
name: Jugessur, Astanand
name: Kvalvik, Liv G.
name: Morken, Nils-Halvdan
name: Ramlau-Hansen, Cecilia H.
name: Myrskylä, Mikko
name: Magnus, Per
name: Håberg, Siri E.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: Additional file 1. Supplemental results, including Tables S1-S12 and Fig. S1-S13. Table S1. Background characteristics in eligible population of MoBa pregnancies. Table S2. Evaluation of the predictive value of the epigenetic age estimates. Table S3. Pearson correlation between epigenetic age acceleration estimates among mothers. Table S4. Correlation between epigenetic age acceleration estimates among fathers. Table S5. Correlation between epigenetic age acceleration estimates between partners. Fig S1. Smoothed plots of gestational length according to maternal epigenetic age acceleration. Fig S2. Smoothed plots of gestational length according to paternal epigenetic age acceleration. Fig S3. Smoothed plots of standardized birthweight according to maternal epigenetic age acceleration. Fig S4. Smoothed plots standardized birthweight according to paternal epigenetic age acceleration. Table S6. Distribution of adverse birth outcomes. Fig S5. Mean difference in gestational length and standardized birthweight according to parental epigenetic age acceleration with adjustment for cell type composition and gestational week of blood sampling. Fig S6. Risk of adverse birth outcomes according to parental epigenetic age acceleration with adjustment for cell type composition and gestational week of blood sampling. Fig S7. Mean difference in gestational length and standardized birthweight according to parental epigenetic age acceleration with adjustment for parity, education, smoking, body-mass index, diabetes and chronic hypertension. Fig S8. Risk of adverse birth outcomes according to parental epigenetic age acceleration for parity, education, smoking, body-mass index, diabetes and chronic hypertension. Fig S9. Mean difference in gestational length and standardized birthweight according to parental epigenetic age acceleration with adjustment for partner’s epigenetic age acceleration. Fig S10. Risk of adverse birth outcomes according to parental epigenetic age acceleration with adjustment for partner’s epigenetic age acceleration. Fig S11. Mean difference in gestational length and standardized birthweight according to parental epigenetic age acceleration using last menstrual period instead of ultrasound estimated gestational length. Fig S12. Risk of adverse birth outcomes according to parental epigenetic age acceleration using last menstrual period instead of ultrasound estimated gestational length. Fig S13. Risk of post-term birth according to parental epigenetic age acceleration using a survival analysis approach. Table S7. Differences in standardized birthweight and gestational age according to epigenetic age acceleration stratified by chronological age. Table S8. Differences in the odds of adverse birth outcomes according to parental epigenetic age acceleration stratified by chronological age. Table S9. Differences in standardized birthweight and gestational age according to categories of epigenetic age acceleration. Table S10. Differences in the odds of adverse birth outcomes according to categories of epigenetic age acceleration. Table S11. Differences in standardized birthweight and gestational age stratified by offspring sex. Table S12. Differences in the odds of adverse birth outcomes stratified by offspring sex.