cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Asiageodromicus trapezipennis Shavrin 2024, comb. n.
Creators: name: Shavrin, Alexey V.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Asiageodromicus
Asiageodromicus trapezipennis

description: Asiageodromicus trapezipennis (Coiffait, 1979) comb. n.
Geodromicus trapezipennis Coiffait, 1979: 563; Herman 2001: 306, Smetana 2004: 245, Schülke & Smetana 2015: 315.
Type material examined. Syntype of Geodromicus trapezipennis Coiffait, 1979 ♀: ‘Kouchtous Torrentourlach 2300–3250 8.[19]76’ , ‘Allotype’ , ‘ Geodromicus trapezipennis H. Coiffait 1978 ’ (MHNH).
Remarks. Geodromicus trapezipennis was originally described from “” Nouristan, vallée de l`Agôr Khwar, 2 000–3 000 m…”and “Kouchtous, torrent Ourlach, 2 700–3 250 m …” (Afghanistan). Based on the study of the syntype from MHNH, the original description and the general shape of the aedeagus (fig. 4B in Coiffait 1979), this species belongs to the genus Asiageodromicus.
description: Published as part of Shavrin, Alexey V., 2024, Review of Hygrogeus Mulsant & Rey, 1880 and Trichodromeus Luze, 1903, with descriptions of three new genera from the eastern Palaearctic Region (Coleoptera: Staphylinidae: Anthophagini: Omaliinae), pp. 1-62 in Zootaxa 5531 (1) on page 39, DOI: 10.11646/zootaxa.5531.1.1, http://zenodo.org/record/14023033
Sustainability in industrial design education: developing innovation through local techniques and more holistic constraints
Creators: name: Melles, Gavin
name: de Vere, Ian
name: Bissett-Johnson, Katherine
name: Strachan, Mark
Publisher: name: Swinburne
Year: 2024

description: Concern about 'sustainability' is becoming ubiquitous in many domains of life. First emerging in the 1970s, the term quickly spread from ecology to economics and other areas to become a new global philosophy. Today, the concept of 'sustainability' is used in such varying contexts that it has been suggested that any generic meaning is impossible. Thus, in areas such as economic development, it tends to be a catchall term for a range of phenomena. Despite this semantic ambiguity, the term continues to flag lifestyle choices pursued without regard for long-term environmental and socioeconomic consequences. Sustainability agendas and education in design fields sometimes consider the broader domains of socio-economic and human concerns, while others are more narrowly focused on specific design processes. Birkeland, for example, focuses on integrated systems design—eco-solutions that encompass social, political, and economic factors and that radically reduce resource use while increasing health, equity, and life quality.
Building employee engagement and reputation through storytelling
Creators: name: Gill, Robert
Publisher: name: Swinburne
Year: 2024

description: Organisational storytelling can be used as an effective means to improve engagement between employers and staff by communicating and reinforcing the employee opportunities, developments and benefits associated with working for the organisation. The characteristics of storytelling make it an excellent medium for the organisation to engage with employees on a more personal level and can aid in the retention of information valuable to building an employee-focussed work culture. Employer of choice (EOC) for Australian organisations is an emerging issue, as it relates to the way organisations provide a safe, healthy and progressive work environment. By informing employees about their EOC structure through stories, a stronger commitment can be fostered towards their organisation, resulting in improved reputation, both internally and externally. The use of organisational stories as an internal communication instrument may result in employees becoming reputation champions for their organisation. Narration that positively represents the organisation can be adopted by staff and adapted to become more relevant to the particular stakeholders they encounter through their work. Staff who are more engaged with, and have a deep trust for, their employer are likely to feel more buoyant about their work and conduct themselves in a constructive manner. This often results in improved productivity, a healthier brand and a decreased risk of losing staffing.
Test of two hypotheses explaining the size of populations in a system of cities
Creators: name: Vitanov, Nikolay K.
name: Ausloos, Marcel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology
subject: Physics

description: Two classical hypotheses are examined about the population growth in a system of cities: Hypothesis 1 pertains to Gibrat's and Zipf's theory which states that the city growth–decay process is size independent; Hypothesis 2 pertains to the so-called Yule process which states that the growth of populations in cities happens when (i) the distribution of the city population initial size obeys a log-normal function, (ii) the growth of the settlements follows a stochastic process. The basis for the test is some official data on Bulgarian cities at various times. This system was chosen because (i) Bulgaria is a country for which one does not expect biased theoretical conditions; (ii) the city populations were determined rather precisely. The present results show that: (i) the population size growth of the Bulgarian cities is size dependent, whence Hypothesis 1 is not confirmed for Bulgaria; (ii) the population size growth of Bulgarian cities can be described by a double Pareto log-normal distribution, whence Hypothesis 2 is valid for the Bulgarian city system. It is expected that this fine study brings some information and light on other usually considered to be more pertinent countries of city systems.
A framework for the facilitation of accelerated leadership and management capability development in the workplace
Creators: name: Harper, Gregory
name: Cameron, Ros
name: Edwards, Christine
Publisher: name: Torrens University Australia
Year: 2024
Subjects: classificationCode: 350707
subject: Leadership

description: A holistic framework for the design of leadership and management programs to accelerate leadership and management capability development in the workplace is presented. Previous models and frameworks have been primarily based on program design inputs and outcomes and have not adequately considered the mediating role of learning processes and learner preferences in the relationship between program design inputs and outcomes. Additionally, most existing models and frameworks do not offer holistic approaches. Four theoretical implications and five practical applications of the framework are presented. The three defining features of the leadership and management learning framework are the focus on the development of competencies that underpin effective leadership, the central role of learning facilitation in this development, and the workplace learning processes that enable leadership and management development, and specifically meta-learning processes. Contributions to theory involve the integration of meta-learning and facilitation in the framework and the six propositions posited. A series of practical implications for advancing leadership program design, delivery and evaluation is also presented.
MPEC 2024-L113 : 2024 LZ2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 LZ2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Ranking and mappping of universities and research-focused institutions worldwide: The third release of excellencemapping.net
Creators: name: Bornmann, Lutz
name: Stefaner, Moritz
name: Anegón, Félix De Moya
name: Mutz, Rüdiger
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Bornmann, Stefaner, de Moya Anegón, and Mutz (2014a) have introduced a web application (www.excellencemapping.net) which is linked to both academic ranking lists published hitherto (e.g. the Academic Ranking of World Universities) as well as spatial visualization approaches. The application visualizes the performance of institutions worldwide within specific subject areas (journal sets from Scopus) as institutional ranking lists and on custom tile-based maps. Scopus data were used which are also the base for the SCImago Institutions Ranking. The second, enhanced version of the excellencemapping.net is described in Bornmann, Stefaner, de Moya Anegón, and Mutz (2014b). In this version, the effect of covariates (such as the perceived corruption in a country in which a research institution is located) on two performance metrics (best paper rate and best journal rate) is examined and visualized. This paper describes the third version based on new data.
Digital Forensic and Cloud Computing
Creators: name: Sarvesh Kumar Pathak
name: Sadeep Kumar Pathak
name: A. K. Gupta
Publisher: name: figshare
Year: 2015
Subjects: subject: Computer Engineering
subject: Information Systems
subject: FOS: Computer and information sciences

description: In computer networking, cloud computing is the computer network that have a large number of computers connected to communicable media/communication network such as Internet, having the ability to run a program/application on many connected computers at the same time; therefore, cloud computing also known as distributed computing over a network. Increasing interest as well as use of cloud computing increases the opportunities for criminal exploitation and challenges for LEAs (Law Enforcement Agencies), especially with respect to data protection policies. Therefore, present work demonstrates to identify the required challenge to current forensic investigation needed to successfully conduct cloud computing investigation, and propose an integrated concept, which emphasizes the preservation of forensic data collection of cloud computing data for forensic purpose. Keywords
Cloud Computing, Digital Forensic Investigation for Cloud Computing, LEAs.
Interaction of RuIII(EDTA) with cellular thiols and O2: biological implications thereof
Creators: name: Debabrata Chatterjee
name: Jaiswal, Namita
name: Jagadeesh C. Bose K
name: Mahato, Ram Balak
name: Diptendu Bhattacharyya
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Reaction of [RuIII(EDTA)(CyS)]2− (edta4− = ethylenediaminetetraacetate; CySH = cysteine) with molecular oxygen (O2) has been studied as a function of pH (4.0–8.0) and cysteine concentration (0.2–2.0 mM) at room temperature (25 °C). Biological activities of the [Ru(EDTA)]/CySH/O2 system pertaining to cleavage of supercoiled plasmid DNA to its nicked open circular form has been explored in this work. Results are discussed in regard to the reaction of the ruthenium(III)-complex with molecular oxygen) and a working mechanism is proposed for the biological activities of the ruthenium(III)-complex in the presence of O2.
The genealogy of Quality 4.0
Creators: name: Bhat, Shreeranga
name: Jayaraman, Raja
name: Antony, Jiju
name: Sony, Michael
name: McDermott, Olivia
name: Snee, Ronald
Publisher: name: figshare
Year: 2022
Subjects: subject: 91599 Interdisciplinary Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: The genealogy of Quality 4.0: From inspection to automation, the quest to meet standards evolves
Reputation and responsibility: employee of choice
Creators: name: Gill, Robert
Publisher: name: Swinburne
Year: 2024

description: Australian business is in a period of heightened transparency and accountability, driven by a growing global obligation for business to demonstrate corporate responsibility for their operations. Reputation and corporate social responsibility have become key determinants of a company's performance. These two features of business operations are strongly influenced by an organisation's employer of choice program.
Interaction of RuIII(EDTA) with cellular thiols and O2: Biological implications thereof
Creators: name: Debabrata Chatterjee
name: Jaiswal, Namita
name: Jagadeesh C. Bose K
name: Mahato, Ram Balak
name: Diptendu Bhattacharyya
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Reaction of [RuIII(EDTA)(CyS)]2− (edta4− = ethylenediaminetetraacetate; CySH = cysteine) with molecular oxygen (O2) have been studied as a function of pH (4.0-8.0) and cysteine concentration (0.2-2.0 mM) at room temperature (25 °C). Biological activities of the [Ru(EDTA)]/CySH/O2 system pertaining to cleavage of supercoiled plasmid DNA to its nicked open circular form has been explored in this work. Results are discussed in regard to the reaction of the ruthenium(III)-complex with molecular oxygen) and a working mechanism is proposed for the biological activities of the ruthenium(III)-complex in the presence of O2.
The development of private higher education in a mature market: a New Zealand case study
Creators: name: Xiaoying, Ma
name: Abbott, Malcolm
Publisher: name: Swinburne
Year: 2024

description: Since 1989, when it became legally possible for private higher education to operate in New Zealand, the sector has grown to become a significant part of the country's higher education system. This paper explores the private penetration, traces the changes that have occurred in private higher education, and evaluate the sector's position in New Zealand today. The private sector has had to find a niche for itself in a higher education sector dominated by a mature, well developed public sector. In so doing, New Zealand's private higher education exhibits differences and similarities with private higher education sector internationally. The New Zealand case is one of private entry into a mature higher education system in an economically advanced country. Emphasis is also placed on the dissimilarities between the private sector and the more predominant public tertiary education institutions in New Zealand. It is clear from this study that the private sector has characteristics that clearly distinguish it from the public higher education sector in New Zealand.
Social Networks as Sites of e-Participation in Local Government
Creators: name: Holland, Travis
Publisher: name: figshare
Year: 2015
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications

description: This paper proposes that electronic social network sites (SNS) make visible forms of participatory behaviour to which local governments must respond. Groups and individuals – publics – operating in diverse ways for diverse purposes, propagate and respond to communication by local governments via SNS and, in doing so, practice electronic e-participation. In addition to alternate channels of communication, SNS can facilitate alternate forms of participatory behaviour online, but there is little alignment between public perceptions of these emerging practices and local government behaviours in the same space. The publics seeking to engage with local governments on SNS, expect that their participation should be both sought and valued, but local governments are active on social networks for different purposes, primarily information sharing. A study of the main social network channels of five local governments, in and around the Illawarra region of New South Wales, reveals that local governments are neither aware of this shift in public e-participation expectations, nor equipped to understand them. In particular, certain forms of e-participatory behaviour are not recognised by the local governments as genuine forms of participation. Nonetheless, there are some promising signs that local governments are making efforts to acknowledge and respond to publics and individuals on SNS, pointing to opportunities for more active engagement between publics and councils.
Estudos métricos da informação na web e o papel dos profissionais da informação
Creators: name: Araujo, Ronaldo
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Aborda os estudos métricos aplicados à web e reflete sobre seu uso em ambientes de interação como sites de redes sociais. Destaca os conceitos de webometria, cibermetria e altmetria, traçando as diferenças entre seus métodos, aplicações e suas interfaces com os campos da bibliometria e a cientometria. Considera a abordagem cibermétrica de maior abrangência e mais adequada para estudos quantitativos em blogs e sites de redes sociais e situa a altmetria como emergente campo de estudos para análise da circulação da informação científica na websocial, que tem muito a crescer com o envolvimento dos profissionais da informação atuando na geração e monitoramento de dados e no apoio a pesquisadores e instituições de pesquisa.
Mídias sociais e comunicação científica: análise altmétrica em artigos de periódicos da ciência da informação
Creators: name: Araujo, Ronaldo
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Este estudo discorre brevemente sobre as mídias sociais e a comunicação científica, situando o emergente campo da altmetria para análise dessa relação. Apresentam-se aqui os resultados de uma pesquisa exploratória que teve por objetivo a análise de métricas alternativas para 125 artigos de periódicos da Ciência da Informação Qualis A. No uso da ferramenta altmetric.com, 36% dos artigos retornaram dados altmétricos. Dentre as revistas, dá-se destaque para a Ciência da Informação, com 21 artigos e 297 dados altmétricos. Quanto às mídias, 92,43% dos dados vieram do Mendeley, contra 7,57% do Twitter, e nenhum registro do Facebook. Considera-se que a falta de padronização das revistas pode ser um dos fatores do reduzido quantitativo de artigos encontrado, e que parametrizações de Application Programming Interface – APIs de mídias como Facebook e Twitter – podem ser o caminho para contornar esse baixo desempenho. Os dados altmétricos indicam a atenção que os artigos recebem logo após a publicação e podem ser indícios de citações futuras.
Broadband and the 'Creative Internet': Australians as consumers and producers of cultural content online
Creators: name: Ewing, Scott
name: Thomas, Julian
Publisher: name: Swinburne
Year: 2024

description: This paper analyses and builds on sample survey data collected as part of the Australian component of the World Internet Project. The focus of this paper is on what we can call the ‘creative Internet’ — in brief, those ‘creative uses’ of the net ranging from relatively straightforward user-generated content such as sharing photographs to the distribution of more complex amateur-produced material. We present a brief overview of the ‘creative Internet’ in Australia, and its relationship to the take-up of broadband access. We examine the roles that age, gender and broadband access play in user’s propensity to engage in creative uses of the technology, as well as respondents’ attitudes to these endeavours.
Supplementary Figures from Multi-trait diversification in marine diatoms in constant and warmed environments
Creators: name: Hinners, Jana
name: Argyle, Phoebe A.
name: Walworth, Nathan G.
name: Doblin, Martina A.
name: Levine, Naomi M.
name: Collins, Sinéad
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 310799
subject: Microbiology not elsewhere classified

description: Supplementary Figures
Application of normalisation process theory in understanding implementation processes in primary care settings in the UK: a systematic review.
Creators: name: Huddlestone, Lisa
name: Turner, Jessica
name: Eborall, Helen
name: Hudson, Nicky
name: Davies, Melanie
name: Martin, Graham
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: General Practice
United Kingdom
Primary Care
Complex Interventions
Npt
Normalisation Process Theory

description: BACKGROUND:Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have examined the application of NPT across international healthcare and reports its benefits. However, given the distinctive clinical function, organisational arrangements and the increasing management of people with a wide variety of conditions in primary care settings in the United Kingdom, it is important to understand how and why authors utilise and reflect on NPT in such settings to inform and evaluate implementation processes. METHODS:A systematic review of peer-reviewed literature using NPT in primary care settings in the United Kingdom (UK) was conducted. Eight electronic databases were searched using replicable methods to identify articles published between January 2012 and April 2018. Data were analysed using a framework approach. RESULTS:Thirty-one articles met the inclusion criteria. Researchers utilised NPT to explore the implementation of interventions, targeting a wide range of health services and conditions, within primary care settings in the UK. NPT was mostly applied qualitatively; however, a small number of researchers have moved towards mixed and quantitative methods. Some variation was observed in the use of NPT constructs and sub-constructs, and whether and how researchers undertook modification to make them more relevant to the implementation process and multiple stakeholder perspectives. CONCLUSION:NPT provides a flexible framework for the development and evaluation of complex healthcare interventions in UK primary care settings. This review updates the literature on NPT use and indicates that its application is well suited to these environments, particularly in supporting patients with long-term conditions and co-morbidities. We recommend future research explores the receipt of interventions by multiple stakeholders and suggest that authors reflect on justifications for using NPT in their reporting.
Estimating epidemiological parameters from experiments in vector access to host plants, the method of matching gradients.
Creators: name: Donnelly, Ruairí
name: Sikazwe, Geofrey W
name: Gilligan, Christopher A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Estimation of pathogenic life-history values, for instance the duration a pathogen is retained in an insect vector (i.e., retention period) is of particular importance for understanding plant disease epidemiology. How can we extract values for these epidemiological parameters from conventional small-scale laboratory experiments in which transmission success is measured in relation to durations of vector access to host plants? We provide a solution to this problem by deriving formulae for the empirical curves that these experiments produce, called access period response curves (i.e., transmission success vs access period). We do this by writing simple equations for the fundamental life-cycle components of insect vectors in the laboratory. We then infer values of epidemiological parameters by matching the theoretical and empirical gradients of access period response curves. Using the example of Cassava brown streak virus (CBSV), which has emerged in sub-Saharan Africa and now threatens regional food security, we illustrate the method of matching gradients. We show how applying the method to published data produces a new understanding of CBSV through the inference of retention period, acquisition period and inoculation period parameters. We found that CBSV is retained for a far shorter duration in its insect vector (Bemisia tabaci whitefly) than had previously been assumed. Our results shed light on a number of critical factors that may be responsible for the transition of CBSV from sub- to super-threshold R0 in sub-Saharan Africa. The method is applicable to plant pathogens in general, to supply epidemiological parameter estimates that are crucial for practical management of epidemics and prediction of pandemic risk.
Nipped in the bud: Clement Meadmore's interior for the Teahouse
Creators: name: Carter, Nanette
Publisher: name: Swinburne
Year: 2024

description: It is widely known that prior to embarking on a successful international career as a sculptor, Clement Meadmore was an influential Australian designer of furniture and of the interior of the groundbreaking modernist Legend Espresso and Milk Bar in Melbourne in 1955. With its black metal and fibreglass furniture, semi-abstract murals by artist Leonard French and its brilliant colour scheme, the Legend was Melbourne's most remarkable café interior at the time when the city was gearing up to host the Olympic Games and doing its best to live up to the image of a progressive and cosmopolitan city. What appears to have been overlooked is that Meadmore designed a second café and milk bar called the Teahouse for Ion Nicolades, the same client who had commissioned the Legend. In its short life the relatively simple interior of the Teahouse embodied a complex mix of competing narratives. Based on the traditional British model of the ladies' tearoom, it incorporated allusions to colonial mastery over subject peoples and fantasies of empire inspired by the exotic origins of the everyday commodity of tea. Other references include an irreverent recoding of Victorian vernacular style and lingering features of streamline moderne styling that characterised the design of Australian milk bars. It also derived elements of design from Scandinavian and American modernism. This paper brings to light Meadmore's forgotten interior for the Teahouse and, referring to theories of the commodity spectacle and spectacular space, seeks to explore the way its diverse and competing narratives operated in a quirky melange. It also uses postcolonial theory to explore the way in which it supported continued identification with 'Britishness' and allegiance to the British Empire in the female citizens of a former settler colony, while simultaneously gesturing towards a fundamentally internationalist outlook through the language of functional modernism.
Nutritional adequacy and dietary disparities in an adult Caribbean population of African descent with a high burden of diabetes and cardiovascular disease.
Creators: name: Harris, Rachel M
name: Rose, Angela M C
name: Forouhi, Nita G
name: Unwin, Nigel
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Diet
Barbados
Nutritional Adequacy
Sugar‐sweetened Beverages

description: The Caribbean island of Barbados has a high burden of diabetes and cardiovascular disease. Dietary habits were last described in 2005. A representative population-based sample (n = 363, aged 25-64 years) provided two nonconsecutive 24-hr dietary recalls in this cross-sectional study. Mean daily nutrient intakes were compared with the Dietary Guidelines for Americans. Subgroup differences by age, sex, and educational level were examined using logistic regression. High sugar intakes exist for both sexes with 24% (95% CIs 18.9, 30.0) consuming less than the recommended <10% of energy from added sugars (men 22%; 15.0, 31.6; women 26%; 18.9, 33.7). Sugar-sweetened beverages provide 43% (42.2%, 44.4%) of total sugar intake. Inadequate dietary fiber intakes (men 21 g, 18.2, 22.8; women 18 g, 16.7, 18.9) exist across all age groups. Inadequate micronutrient intake was found in women for calcium, folate, thiamine, zinc, and iron. Older persons (aged 45-64 years) were more likely to report adequacy of dietary fiber (OR = 2.7, 1.5, 4.8) and iron (OR = 3.0, 1.7, 5.3) than younger persons (aged 25-44). Older persons (aged 45-64 years) were less likely to have an adequate supply of riboflavin (OR = 0.4, 0.2, 0.6) than younger persons. Men were more likely to have adequate intakes of iron (OR = 13.0, 6.1, 28.2), folate (OR = 2.4, 1.3, 4.6), and thiamine (OR = 3.0, 1.5, 5.0) than women. Education was not associated with nutrient intake. The Barbadian diet is characterized by high sugar intakes and inadequate dietary fiber; a nutrient profile associated with an increased risk of obesity, type 2 diabetes, and related noncommunicable diseases.
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation: findings from UK Biobank and associations with disease outcomes.
Creators: name: Pearce, Matthew
name: Strain, Tessa
name: Kim, Youngwon
name: Sharp, Stephen J
name: Westgate, Kate
name: Wijndaele, Katrien
name: Gonzales, Tomas
name: Wareham, Nicholas J
name: Brage, Søren
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Questionnaire
calibration
Accelerometer
Physical Activity Energy Expenditure
Doubly Labelled Water

description: BACKGROUND:UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In contrast, the main cohort has multiple self-reported physical behaviours from > 500,000 participants with longer follow-up time, offering several epidemiological advantages. However, questionnaire methods typically suffer from greater measurement error, and at present there is no tested method for combining these diverse self-reported data to more comprehensively assess the overall dose of physical activity. This study aimed to use the accelerometry sub-cohort to calibrate the self-reported behavioural variables to produce a harmonised estimate of physical activity energy expenditure, and subsequently examine its reliability, validity, and associations with disease outcomes. METHODS:We calibrated 14 self-reported behavioural variables from the UK Biobank main cohort using the wrist accelerometry sub-cohort (n = 93,425), and used published equations to estimate physical activity energy expenditure (PAEESR). For comparison, we estimated physical activity based on the scoring criteria of the International Physical Activity Questionnaire, and by summing variables for occupational and leisure-time physical activity with no calibration. Test-retest reliability was assessed using data from the UK Biobank repeat assessment (n = 18,905) collected a mean of 4.3 years after baseline. Validity was assessed in an independent validation study (n = 98) with estimates based on doubly labelled water (PAEEDLW). In the main UK Biobank cohort (n = 374,352), Cox regression was used to estimate associations between PAEESR and fatal and non-fatal outcomes including all-cause, cardiovascular diseases, respiratory diseases, and cancers. RESULTS:PAEESR explained 27% variance in gold-standard PAEEDLW estimates, with no mean bias. However, error was strongly correlated with PAEEDLW (r = -.98; p
Modelling motivation and consumption for cultural experiences
Creators: name: Kay, Pandora
name: Meyer, Denny
Publisher: name: Swinburne
Year: 2024

description: This empirical research aims to advance knowledge about the tourist market in general for attending cultural experiences, such as those offered at cultural attractions as well as the more temporal cultural performances and events. It specifically seeks to understand some of the multiple psychological aspects of relevance to tourists' motivation towards cultural experiences, the underlying dimensions, and the associations and relationships that may occur between them. It adopts a process approach to modelling motivation and consumption for cultural experiences and tests four psychological dispositions: attitudes, motives, benefits sought, and benefits gained. This model and related hypotheses are tested with data for English-speaking Western tourists and then analysed using SEM and MANOVA for gender and age differences. The model is supported for these tourists with no significant differences for gender or age. A complex underlying dimensionality is supported for each of the four constructs in the model and positive associations between the constructs are largely found with two exceptions: a link between attitudes and benefits sought is not supported apart from a mediated relationship via motives, and a largely negative relationship between motives and benefits gained, reveals complex interrelationships that warrant further research.
Squamousness: Next-Generation Sequencing Reveals Shared Molecular Features Across Squamous Tumor Types
Creators: name: Schwaederle, Maria
name: Elkin, Sheryl K
name: Tomson, Brett N
name: Carter, Jennifer Levin
name: Razelle Kurzrock
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering

description: ABSTRACTIn order to gain a better understanding of the underlying biology of squamous cell carcinoma (SCC), we tested the hypothesis that SCC originating from different organs may possess common molecular alterations. SCC samples (N=361) were examined using clinical-grade targeted next-generation sequencing (NGS). The most frequent SCC tumor types were head and neck, lung, cutaneous, gastrointestinal and gynecologic cancers. The most common gene alterations were TP53 (64.5% of patients), PIK3CA (28.5%), CDKN2A (24.4%), SOX2 (17.7%), and CCND1 (15.8%). By comparing NGS results of our SCC cohort to a non-SCC cohort (N=277), we found that CDKN2A, SOX2, NOTCH1, TP53, PIK3CA, CCND1, and FBXW7 were significantly more frequently altered, unlike KRAS, which was less frequently altered in SCC specimens (all P<0.05; multivariable analysis). Therefore, we identified “squamousness” gene signatures (TP53, PIK3CA, CCND1, CDKN2A, SOX2, NOTCH 1, and FBXW7 aberrations, and absence of KRAS alterations) that were significantly more frequent in SCC versus non-SCC histologies. A multivariable co-alteration analysis established two SCC subgroups: (i) patients in whom TP53 and cyclin pathway (CDKN2A and CCND1) alterations strongly correlated but in whom PIK3CA aberrations were less frequent; and (ii) patients with PIK3CA alterations in whom TP53 mutations were less frequent (all P≤0.001, multivariable analysis). In conclusion, we identified a set of eight genes altered with significantly different frequencies when SCC and non-SCC were compared, suggesting the existence of patterns for “squamousness.” Targeting the PI3K-AKT-mTOR and/or cyclin pathway components in SCC may be warranted.
Formation and Growth of Clusters of Sulfur Dioxide
Creators: name: Harnes, Jarle
name: Abu-Samha, Mahmoud
name: Winkler, Mathias
name: Børve, Knut J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Formation and growth of neutral SO2 clusters is investigated in an adiabatic-expansion setup by means of sulfur 2p (S2p) photoelectron spectroscopy and theoretical modeling. The shift in S2p ionization energy between the cluster and a single molecule, i.e., IE(cluster)-IE(monomer), is recorded and used to monitor the mean cluster size over a wide range of expansion conditions. The produced clusters were shown to fall into two different size regimes. Comparison between theoretical simulations and experimental observations suggests that while the smallest clusters belong to the ultrafine particle mode and have a liquid-like structure, the larger clusters belong to the accumulation mode of fine particles and possibly have a frozen cluster core. The transition between the two size/structure regimes occurs over a narrow interval in expansion conditions and may possibly reflect a change in growth mechanism from monomer addition to growth by cluster-cluster collisions.(c) Jarle Harnes, Mahmoud Abu-Samha, Mathias Winkler, and Knut J. Børve
Studies Toward Synthesis of Tetracyclic Core of Daphmanidin A–Type Alkaloids
Creators: name: Vishwakarma Singh
name: Beauty Das
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Biotechnology
Cell Biology
Biochemistry

description: A stereoselective approach to spiro-annulated bicyclo[2.2.2]octane ring system related to the tetracyclic skeleton of daphmanidin A–type alkaloids is described. Ring-closing metathesis, Wacker oxidation, and aldol condensation are key features ofour approach. An interesting steric effect on aldol condensation has also been observed.
Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types
Creators: name: Schwaederle, Maria
name: Elkin, Sheryl K
name: Tomson, Brett N
name: Carter, Jennifer Levin
name: Razelle Kurzrock
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering

description: In order to gain a better understanding of the underlying biology of squamous cell carcinoma (SCC), we tested the hypothesis that SCC originating from different organs may possess common molecular alterations. SCC samples (N = 361) were examined using clinical-grade targeted next-generation sequencing (NGS). The most frequent SCC tumor types were head and neck, lung, cutaneous, gastrointestinal and gynecologic cancers. The most common gene alterations were TP53 (64.5% of patients), PIK3CA (28.5%), CDKN2A (24.4%), SOX2 (17.7%), and CCND1 (15.8%). By comparing NGS results of our SCC cohort to a non-SCC cohort (N = 277), we found that CDKN2A, SOX2, NOTCH1, TP53, PIK3CA, CCND1, and FBXW7 were significantly more frequently altered, unlike KRAS, which was less frequently altered in SCC specimens (all P < 0.05; multivariable analysis). Therefore, we identified “squamousness” gene signatures (TP53, PIK3CA, CCND1, CDKN2A, SOX2, NOTCH 1, and FBXW7 aberrations, and absence of KRAS alterations) that were significantly more frequent in SCC versus non-SCC histologies. A multivariable co-alteration analysis established 2 SCC subgroups: (i) patients in whom TP53 and cyclin pathway (CDKN2A and CCND1) alterations strongly correlated but in whom PIK3CA aberrations were less frequent; and (ii) patients with PIK3CA alterations in whom TP53 mutations were less frequent (all P ≤ 0 .001, multivariable analysis). In conclusion, we identified a set of 8 genes altered with significantly different frequencies when SCC and non-SCC were compared, suggesting the existence of patterns for “squamousness.” Targeting the PI3K-AKT-mTOR and/or cyclin pathway components in SCC may be warranted.
p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency
Creators: name: Prachi N Ghule
name: Xie, Rong-Lin
name: Colby, Jennifer L
name: Jones, Stephen N
name: Lian, Jane B
name: Wijnen, Andre J Van
name: Stein, Janet L
name: Stein, Gary S
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes. Ablation of Hinfp and consequential depletion of histones alter nucleosome spacing and cause stalled replication and DNA damage that ultimately result in genomic instability. Faithful replication and packaging of newly replicated DNA are required for normal cell cycle control and proliferation. The tumor suppressor protein p53, the guardian of the genome, controls multiple cell cycle checkpoints and its loss leads to cellular transformation. Here we addressed whether the absence of p53 impacts the outcomes/consequences of Hinfp-mediated histone H4 deficiency. We examined mouse embryonic fibroblasts lacking both Hinfp and p53. Our data revealed that the reduced histone H4 expression caused by depletion of Hinfp persists when p53 is also inactivated. Loss of p53 enhanced the abnormalities in nuclear shape and size (i.e. multi-lobed irregularly shaped nuclei) caused by Hinfp depletion and also altered the sub-nuclear organization of Histone Locus Bodies (HLBs). In addition to the polyploid phenotype resulting from deletion of either p53 or Hinfp, inactivation of both p53 and Hinfp increased mitotic defects and generated chromosomal fragility and susceptibility to DNA damage. Thus, our study conclusively establishes that simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation.
Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types
Creators: name: Schwaederle, Maria
name: Elkin, Sheryl K
name: Tomson, Brett N
name: Carter, Jennifer Levin
name: Razelle Kurzrock
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In order to gain a better understanding of the underlying biology of squamous cell carcinoma (SCC), we tested the hypothesis that SCC originating from different organs may possess common molecular alterations. SCC samples (N = 361) were examined using clinical-grade targeted next-generation sequencing (NGS). The most frequent SCC tumor types were head and neck, lung, cutaneous, gastrointestinal and gynecologic cancers. The most common gene alterations were TP53 (64.5% of patients), PIK3CA (28.5%), CDKN2A (24.4%), SOX2 (17.7%), and CCND1 (15.8%). By comparing NGS results of our SCC cohort to a non-SCC cohort (N = 277), we found that CDKN2A, SOX2, NOTCH1, TP53, PIK3CA, CCND1, and FBXW7 were significantly more frequently altered, unlike KRAS, which was less frequently altered in SCC specimens (all P < 0.05; multivariable analysis). Therefore, we identified “squamousness” gene signatures (TP53, PIK3CA, CCND1, CDKN2A, SOX2, NOTCH 1, and FBXW7 aberrations, and absence of KRAS alterations) that were significantly more frequent in SCC versus non-SCC histologies. A multivariable co-alteration analysis established 2 SCC subgroups: (i) patients in whom TP53 and cyclin pathway (CDKN2A and CCND1) alterations strongly correlated but in whom PIK3CA aberrations were less frequent; and (ii) patients with PIK3CA alterations in whom TP53 mutations were less frequent (all P ≤ 0 .001, multivariable analysis). In conclusion, we identified a set of 8 genes altered with significantly different frequencies when SCC and non-SCC were compared, suggesting the existence of patterns for “squamousness.” Targeting the PI3K-AKT-mTOR and/or cyclin pathway components in SCC may be warranted.
O (Big) Brother, where art thou? Exploring the capabilities of synchronous online communication while supervising experiential learning from a distance
Creators: name: Banky, George
Publisher: name: Swinburne
Year: 2024

description: Good teaching has been described as a 'conversation' or as an 'interactive engagement' that mandates collaboration between all the participants. The applied communication technologies, broadly classified as synchronous or asynchronous, specifically constrain the available environment for the practiced pedagogy in distance education. In the research reported here the capabilities of a commercially available classroom management tool with built-in bi-directional audio communication and a range of computer application-sharing services were explored. This software was used to supervise online students who were performing computer-based experiential learning. Post-event survey and focus groups returned a majority of favourable participant responses. While the described case study was conducted over a local-area network of computers, the on-going developments in technology ensure that the eventual porting of this concept onto a wide-area network, such as the Internet, will be equally beneficial to the distance education delivery of science-based curricula; for example course work in engineering.
Formation and Growth of Clusters of Sulfur Dioxide
Creators: name: Harnes, Jarle
name: Abu-Samha, Mahmoud
name: Winkler, Mathias
name: Børve, Knut J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Formation and growth of neutral SO2 clusters is investigated in an adiabatic-expansion setup by means of sulfur 2p (S2p) photoelectron spectroscopy and theoretical modeling. The shift in S2p ionization energy between the cluster and a single molecule, i.e., IE(cluster)-IE(monomer), is recorded and used to monitor the mean cluster size over a wide range of expansion conditions. The produced clusters were shown to fall into two different size regimes. Comparison between theoretical simulations and experimental observations suggests that while the smallest clusters belong to the ultrafine particle mode and have a liquid-like structure, the larger clusters belong to the accumulation mode of fine particles and possibly have a frozen cluster core. The transition between the two size/structure regimes occurs over a narrow interval in expansion conditions and may possibly reflect a change in growth mechanism from monomer addition to growth by cluster-cluster collisions.(c) Jarle Harnes, Mahmoud Abu-Samha, Mathias Winkler, and Knit J. Børve
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.
Creators: name: Basilico, Silvia
name: Wang, Xiaonan
name: Kennedy, Alison
name: Tzelepis, Konstantinos
name: Giotopoulos, George
name: Kinston, Sarah J
name: Quiros, Pedro M
name: Wong, Kim
name: Adams, David J
name: Carnevalli, Larissa S
name: Huntly, Brian J P
name: Vassiliou, George S
name: Calero-Nieto, Fernando J
name: Göttgens, Berthold
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 (Kmt2a) gene generate powerful oncogenic fusion proteins, predominantly affecting infant and paediatric AML and ALL patients. The early stages of leukaemogenic transformation are typically inaccessible from human patients and conventional mouse models. Here, we take advantage of cells conditionally blocked at the multipotent haematopoietic progenitor stage to develop a MLL-r model capturing early cellular and molecular consequences of MLL-ENL expression based on a clear clonal relationship between parental and leukaemic cells. Through a combination of scRNA-seq, ATAC-seq and genome-scale CRISPR-Cas9 screening, we identify pathways and genes likely to drive the early phases of leukaemogenesis. Finally, we demonstrate the broad utility of using matched parental and transformed cells for small molecule inhibitor studies by validating both previously known and other potential therapeutic targets.