cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Franz Freiherr von John
Creators: name: Held, Johannes
Year: 2008

description: Nur die bedingungslose Hingabe an den Beruf, die Treue zum Herrscherhaus, trotz schlechter Salaire-Verhältnisse, gegenüber gleichgestellten Positionen in anderen Armeen, haben den Bestand der k.k. Monarchie bis zum Ende des Ersten Weltkrieges gewährleistet. Daß unter Verhältnissen solcher Art, wie aus den persönlichen Aufzeichnungen, oben angeführt, hervorgeht, das Offizierscorps als Klammer der bewaffneten Macht von hervorragender Bedeutung anzusehen ist, kann nicht hoch genug bewertet werden. War Baron FZM John, mehr der Praxis und dem Typus nach dem altösterreichischen „Militär“ verpflichtet, dem Grundsatz „Dienen heißt gehorchen, jeder Befehl ist ungefragt zu befolgen“, entsprach Baron Kuhn dem wissenschaftlich denkenden Offizierstypus. Seine Intentionen gingen dahin, das geistige Niveau in der Armee, sowohl des Offizierscorps wie der Mannschaften während der Dienstzeit durch andauernde Schulungen zum „ Mitdenken “, anzuregen. Man bedenke die Schwierigkeiten, welche sich solchen Ideen entgegenstellten. Nichtadelige Herren die gegen konservative Vorstellungen des Hofes Neuerungen einzuführen versuchen, zum Wohl des Vaterlandes, aber gegen den alten „ Zopf “, diese sodann nach langen, zähen Verhandlungen durchzusetzen. Als Beispiele seien erlaubt: Feldgraue Uniformen, um dem Feind den einzelnen Mann im Feld weniger sichtbar zu machen als im weißen Waffenrock, leichtere Kleidung für mehr Beweglichkeit des Einzelnen, Ablehnung des Zündnadelgewehres/ Typ Werndl, die zu erheblichen Mannschaftsverlusten führte, erstmals Ausbau der Reserven,-der Befestigungsanlagen,-der Eisenbahnverbindungen: immer wieder Geldmangel. Wurde ein Krieg verloren, waren natürlich die Militärs schuld. Allein ohne Mittel kann nichts besorgt werden. Dieses Problem, immer genügend finanzielle Mittel für die Wehrmacht bereitgestellt zu finden, schaffte selbst der Kaiser nicht. Beider Herren, wie den der anderen namentlich angeführten und der großen Anzahl nicht genannter Offiziere, Verdienste für ihr Vaterland sollen daher nicht in Vergessenheit geraten.
title: Η συλλογική κατοίκηση ως σενάριο διαχείρισης αποβιομηχανοποιημένων ζωνών
title: Collective housing as a scenario for redeveloping deindustrialized areas
Creators: name: Μουντουρακης Χρηστος
name: Κλειδη Μαρια
Publisher: name: Technical University of Crete
Year: 2024

description: Η παρούσα ερευνητική εργασία πραγματεύεται τη σημασία της συλλογικής
κατοίκησης ως ένα, πιθανό, σενάριο διαχείρισης των εγκαταλελειμμένων βιομηχανικών ζωνών. Πραγματοποιείται πλήρης εμβάθυνση της έννοιας του «συλλογικού», κατά την περίοδο της εκβιομηχάνισης, εστιάζοντας στον τομέα της κατοίκησης και έχει ως στόχο την ανάλυση των δυσμενών επιπτώσεων που προκάλεσε η αποβιομηχάνιση στο αστικό τοπίο. Η ιστορική πορεία αναδεικνύει πως τα παραπάνω γεγονότα αποτελούν θεμέλιο για τη δημιουργία συγκροτημάτων με κύρια χρήση τη συλλογική κατοικία, καθώς επιτρέπουν την ανάπτυξη νέων καινοτόμων δομών με σεβασμό τόσο στο ιστορικό βιομηχανικό κέλυφος όσο και στο γύρω περιβάλλον του. Η προσέγγιση αυτή επιβεβαιώνεται μέσω της διερεύνησης ευρωπαϊκών παραδειγμάτων αναβίωσης brownfields, από τα οποία γίνονται αντιληπτά τα κοινωνικά, οικονομικά και πολιτιστικά οφέλη που προσδίδονται σε μία πόλη.
description: The present research deals with the importance of collective housing as a possible scenario for managing abandoned industrial zones. A full in-depth study of the concept of “collective” is carried out during the period of industrialization, focusing on the area of habitation and aiming to analyze the adverse effects caused by deindustrialization on the urban landscape. The historical course shows that the above events are a foundation for creating complexes with the main use of collective housing, as they allow the development of new innovative structures for both the historical industrial shell and its surrounding environment. This approach is confirmed through the investigation of European examples of brownfields regeneration, from which the social, economic and cultural benefits conferred upon a city.
Çarmıhtan İndiriliş (Roger van der Weyden) Eseri Tanıtımı Çevirisi
Creators: name: Sancak, M. Emir
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Arts
subject: Art history
subject: Modern and contemporary art

description: Rogier van der Weyden'in bu olağanüstü eseri, Yüce İsa'nın acılı veda anını derinlemesine işleyerek bize büyük bir ruhani derinlik sunuyor. Ressamın bu eseri hayata geçirirken duyduğu büyük acı ve ruhsal derinlik, onun sanatının kalbinde yatan insanlık ve inanç temasını güçlendiriyor. O dönemin zenginleri arasında büyük ün kazanmasının ardında yatan şey, bu eserin sanatın sınırlarını aşan etkileyici gücüdür. Ancak şüphesiz ki, bu eser insanlık için yaratılırken, hangi inançtan olursa olsun herkese dokunan bir acıyı da temsil ediyor.

Ressamın duygularını ve detayları bu denli etkileyici bir şekilde aktarması, bu eserin günümüzde bile büyük bir hayranlıkla karşılanmasına yol açıyor. Van der Weyden'in tablosu, insanlık tarihinde derin izler bırakan evrensel bir sanat eseri olarak kabul ediliyor. Bu çeviriyi yaparken dönemin koşullarını ve sanatın gücünü daha iyi anladım. Vikipedi gibi kaynaklardan bilgi çevirirken, yabancı dillerdeki bilgilere olan erişimin önemini bir kez daha kavradım ve bu eseri Türkçe konuşanlarla buluşturmanın değerini anladım.

Umarım bu eser, okuyuculara van der Weyden'in sanatının derinliğini ve insanlık hikayesinin evrenselliğini anlatırken ilham verir ve onları düşündürür. Sanatın gücü ve insanın duygusal derinlikleri konusundaki bu yolculuk, hepimizi daha iyi bir anlayışa ve içsel bir zenginliğe yönlendirebilir.

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Rogier van der Weyden's extraordinary work offers us profound spiritual depth by delving deeply into the poignant farewell moment of Jesus Christ. The profound sorrow and spiritual depth felt by the painter while creating this work strengthen the theme of humanity and faith at the heart of his art. The impressive power of this work, which transcends the boundaries of art, lies behind the great fame it achieved among the elites of its time. However, unquestionably, this work also represents a universal sorrow that resonates with people of all beliefs.

The painter's ability to convey emotions and details in such a compelling manner has led to enduring admiration for this work even in contemporary times. Van der Weyden's painting is recognized as a universal masterpiece that has left deep imprints on the history of humanity. Translating this text has deepened my understanding of the conditions of the time and the power of art. It has also reinforced the importance of accessing information from sources like Wikipedia in foreign languages, and I have come to appreciate the value of bringing this work to Turkish-speaking audiences.

I hope this work inspires readers by revealing the depth of van der Weyden's art and the universality of the human story, prompting them to reflect. This journey into the power of art and the emotional depths of humanity can lead us all to greater understanding and inner richness.
Ah' che per me non v'e : Cavatina
Creators: name: Mayr, Johann Simon
Publisher: name: Published by Grua, Riccordi, & C°., 76 Regent Quadrant Piccadilly
Year: 1827

description: Composed by Mayer, to which are added Ornaments & Graces. By Signor Velluti
description: For unspecified (medium) voice and keyboard instrument
description: Caption title
description: Text by G. Rossi
description: Publication date based on the watermark date (1827) on the Harvard Theatre Collection copy
description: Italian words
UNVEILING SOCIAL MEDIA CLASSIFICATIONS: STRATEGIES FOR IMPACTFUL MARKETING
Creators: name: Shilongo, Michael Ndapewa
Publisher: name: sadi jounal
Year: 2024
Subjects: Social media types, formal social media, informal social media and entertainment social media; impactful marketing

description: Social media usage and applications are on the upsurge. Marketers must synchronize advertising content, consumer profile and social media applications for impactful advertising. Nevertheless, social media applications proportionally grew in numbers and types giving both marketers and consumers endless options and creating confusion in choice. This study used factor analysis to classify social media into three classifications marketers can use to target consumers during social media marketing campaigns. The study suggested novel practical marketing stratagems for social media marketing practitioners. This study pursued a positivist research philosophy. In particular, an empirical research methodological approach was adopted for this study. The reliability of the scales in the research instrument was tested using the Cronbach alpha coefficient. Systematic random sampling was employed to reach a sample of 355 consumers. A self-administered questionnaire was used to collect data. Structural Equation Modelling (SEM) was used to perform regression analysis in validating the research model. Findings revealed three types of social media exist, formal, informal and entertainment social media. Formal social media being the main social media is influenced by entertainment social media and informal social media. In addition, informal social media platforms are WhatsApp, Twitter Instagram, Facebook, and others. While entertainment social media platforms are YouTube and Snapchat. Future research can focus on social media products for marketing as well as focused social media on age marketing. Future studies can determine the relationships between age versus focused social media usage and product versus focused social media correlations.
$\mathrm{SL}_{4}(\mathbf{Z})$ is not purely matricial field
Creators: name: Magee, Michael
name: de la Salle, Mikael
Publisher: name: arXiv
Year: 2023
Subjects: subject: Group Theory (math.GR)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: We prove that every finite dimensional unitary representation of $\mathrm{SL}_{4}(\mathbf{Z})$ contains a non-zero $\mathrm{SL}_{2}(\mathbf{Z})$-invariant vector. As a consequence, there is no sequence of finite-dimensional representations of $\mathrm{SL}_{4}(\mathbf{Z})$ that gives rise to an embedding of its reduced $C^*$-algebra into an ultraproduct of matrix algebras.
description: v2: 9 pages; details added in proof, and example for SL3 made explicit. To appear in Comptes Rendus Math\'ematique
NANOGrav hints for first-order confinement-deconfinement phase transition in different QCD-matter scenarios
Creators: name: Chen, Zu-Cheng
name: Li, Shou-Long
name: Wu, Puxun
name: Yu, Hongwei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent observations from several pulsar timing array (PTA) collaborations have unveiled compelling evidence for a stochastic signal in the nanohertz band. This signal aligns remarkably with a gravitational wave (GW) background, potentially originating from the first-order color charge confinement phase transition. Distinct quantum chromodynamics (QCD) matters, such as quarks or gluons, and diverse phase transition processes thereof can yield disparate GW energy density spectra. In this paper, employing the Bayesian analysis on the NANOGrav 15-year data set, we explore the compatibility with the observed PTA signal of the GW from phase transitions of various QCD matter scenarios in the framework of the holographic QCD. We find that the PTA signal can be effectively explained by the GW from the confinement-deconfinement phase transition of pure quark systems in a hard wall model of the holographic QCD where the bubble dynamics, one important source of the GWs, is of the Jouguet detonations. Notably, our analysis decisively rules out the plausibility of the pure gluon QCD-matter scenario and the non-runaway bubble dynamics model for the phase transition in explaining the observed PTA signal.
description: 7 pages, 2 figures; accepted by PRD
title: Kapitalkostenbestimmung
Creators: name: Gartner, Gerda
Year: 2008

description: Angesichts der Bedeutung der Kapitalkosten für eine wertorientierte Unternehmenssteuerung widmet sich die vorliegende Arbeit dieser Thematik. Zum einen werden diverse Fragestellungen betreffend die Gestaltung der Kapitalkosten beleuchtet, um die in der Literatur und Praxis herrschenden Ansätze und Vorgehensweisen aufzuzeigen, zum anderen werden im Rahmen eines Ein-Agenten- und Zwei-Agenten-Modells die Bestimmungsfaktoren von Kapitalkostensätzen für verschiedene Situationen analysiert. Verglichen werden dabei die kalkulatorischen Kapitalkostensätze bei zentraler Investitionsplanung und dezentraler Investitionssteuerung. Wesentliche Annahme der beiden Modelle ist, dass das Risiko mit der Investitionstätigkeit wächst. Weiters wird von risikoaversen Managern ausgegangen. Aufgrund seiner Risikoaversion und des mit der Investitionstätigkeit verbundenen zusätzlichen Risikos, neigt der Manager zu Unterinvestitionen. Die Zentrale muss nun versuchen, diesem Problem entgegenzuwirken. Über die Kalibrierung des dezentralen Kapitalkostensatzes kann sie das Investitionsverhalten des Managers steuern, sodass er sich im Sinne des Gesamtunternehmens verhält. Aufbauend auf der Ausgangssituation wird das ursprüngliche Modell zu einem Zwei-Agenten-Modell erweitert. Untersucht wird, welche Auswirkungen es auf die Gestaltung der Kapitalkostensätze hat, wenn nicht ein sondern zwei Manager in einer Delegationsbeziehung mit der Zentrale stehen. Betrachtet werden vier verschiedene Szenarien: "Ohne Ressourcenbeschränkung", "Mit Ressourcenbeschränkung", "Shared Assets" und "Exclusive Assets". Dabei stellt sich die Frage, inwiefern sich die optimalen Höhen der zu tätigenden Investitionen sowie die optimalen Kapitalkostensätze in den verschiedenen Szenarien unterscheiden bzw. ob es Effekte gibt, die von der gegebenen technologischen Restriktion unabhängig sind.
Integration of graphene-based superconducting quantum circuits in 3D cavity
Creators: name: Chiu, Kuei-Lin
name: Chang, Youyi
name: Lasrado, Avishma J.
name: Lo, Cheng-Han
name: Chen, Yung-Hsiang
name: Hsu, Tao-Yi
name: Chen, Yen-Chih
name: Tsai, Yi-Chen
name: Samina
name: Lin, Yen-Hsiang
name: Ke, Chung-Ting
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Integrating 2D materials into circuit quantum electrodynamics (c-QED) devices is an emerging filed in recent years. This integration not only facilitates the exploration of potential applications in quantum information processing but also enables the study of material's fundamental properties using microwave techniques. While most studies employ 2D coplanar architectures with scalability potential, 3D cavity based c-QED devices, due to their simpler design, offer the advantage of a quicker turnaround to probe the composite Josephson junctions (JJs). Here, we construct the first flux-tunable, 3D cavity-compatible superconducting quantum circuit based on 2D materials, featuring a graphene superconducting quantum interference device (SQUID) shunted by a capacitor that is accessible by both DC and microwave probes. We have shown how flux-modulated cavity frequency can be linked to the SQUID critical current under the influence of Fraunhofer pattern. In addition, we extracted the symmetry information of the SQUIDs based on DC analysis, and correlated this with the flux-modulated cavity frequency observed in microwave measurements. Our platform can extend to topological materials, holding the prospect of establishing valid topological JJs with DC probe while allowing fast microwave probe to avoid quasiparticle poisoning.
Additional file 5 of Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy
Creators: name: Kitahara, Yoshihiro
name: Inoue, Yusuke
name: Yasui, Hideki
name: Karayama, Masato
name: Suzuki, Yuzo
name: Hozumi, Hironao
name: Furuhashi, Kazuki
name: Enomoto, Noriyuki
name: Fujisawa, Tomoyuki
name: Funai, Kazuhito
name: Honda, Tetsuya
name: Misawa, Kiyoshi
name: Miyake, Hideaki
name: Takeuchi, Hiroya
name: Inui, Naoki
name: Suda, Takafumi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 5: Table S1. Patient characteristics according to post-ICI drug-induced interstitial lung disease.
Supplemental Material - A Scoping Review on Gender/Sex Differences in COVID-19 Vaccine Intentions and Uptake in the United States
Creators: name: Sileo, Katelyn M.
name: Hirani, Inara M.
name: Luttinen, Rebecca L.
name: Hayward, Matt
name: Fleming, Paul J.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Public Health and Health Services not elsewhere classified

description: Supplemental Material for A Scoping Review on Gender/Sex Differences in COVID-19 Vaccine Intentions and Uptake in the United States by Katelyn M. Sileo, Inara M. Hirani, Rebecca L. Luttinen, Matt Hayward, and Paul J. Fleming
Effects of melatonin long-term treatment in aging mice
Creators: name: Favero, Gaia
name: Agabiti-Rosei, Claudia
name: Rossini, Claudia
name: Nardo, Lorenzo
name: Facchetti, Luca
name: Franceschetti, Lorenzo
name: Moretti, Enrico
name: Castrezzati, Stefania
name: Reiter, Russel J.
name: Rizzoni, Damiano
Publisher: name: Firenze University Press
Year: 2017
Subjects: Aging; aorta; melatonin; mesenteric small arteries; oxidative stress

description: Aging is a complex and progressive process involving every organ in the body and it is the result of coordinated biology events that can span decades (1). At cardiovascular level, age-related degeneration and functional decline are quite heterogeneously, nevertheless oxidative stress is a well known pathological process involved. The aim of this study was to investigate the effects of a chronic and long-term treatment with melatonin on functional responses of small mesenteric arteries and on the expression of oxidative stress markers at aorta level of senescence-accelerated prone mice (SAMP8), a model of age-related vascular dysfunction and cognitive decline (2), respect relative controls, senescence-accelerated resistant mice (SAMR1). In the present study were investigated SAMP8 and SAMR1 mice orally treated or not treated for 10 months with melatonin (MelapureTM by Flamma S.p.A.). It was observed that the anticontractile effect of perivascular adipose tissue is impaired in untreated SAMP8, compared with SAMR1. On the contrary, the chronic treatment with melatonin decreased the contractile response to norepinephrine in mesenteric small arteries of SAMP8, restoring an anticontractile effect, probably through melatonin antioxidant mechanisms. In untreated SAMP8 mice was observed at aorta level also an overexpression of oxidative stress and inflammatory markers compared with controls; whereas the long-term treatment with melatonin in SAMP8 was able to increase the expression of some markers of vasculoprotection and to decrease oxidative stress and inflammation. A reduced expression of adiponectin and adiponectin receptor 1 was also observed at visceral fat level of untreated SAMP8 respect SAMR1, while a significant increase was observed after melatonin treatment. In conclusion, melatonin exhibited marked antioxidant and vasculoprotective effects, underlining its potential anti-aging properties at cardiovascular level. Sincere thanks to Flamma S.p.A.-Italy (www.flammagroup.com) for courteously providing the melatonin.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
sj-docx-1-npx-10.1177_1934578X231205727 - Supplemental material for Differentiating Between Three Licorice Species Using SFC-TOF/MS Analysis With Principal Component Analysis
Creators: name: Saito, Hideki
name: Miyoshi, Shozo
name: Murakami, Toshiyuki
name: Suzuki, Ryuichiro
Publisher: name: SAGE Journals
Year: 2023
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-npx-10.1177_1934578X231205727 for Differentiating Between Three Licorice Species Using SFC-TOF/MS Analysis With Principal Component Analysis by Hideki Saito, Shozo Miyoshi, Toshiyuki Murakami and Ryuichiro Suzuki in Natural Product Communications
Heart morphology in Zucker-obese rat
Creators: name: Tayebati, Seyed Khosrow
name: Tomassoni, Daniele
name: Martinelli, Ilenia
name: Amenta, Francesco
Publisher: name: Firenze University Press
Year: 2017
Subjects: Obesity; heart morphology; inflammation; obese Zucker rats

description: Obesity represents the central and causal component of the metabolic syndrome (MetS), which is a growing medical challenge in western countries as a result of changes in lifestyle. Obesity is also associated with an increased incidence of arterial hypertension and of cardiovascular disease burden. In animal models of diet-induced obesity, endothelial inflammatory activation, demonstrated by changes in adhesion molecule expression, is one of the earliest manifestation of vascular and cardiac damage. The intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin (Ig) superfamily present on the surface of several other cell types, including endothelial cells. Adhesion molecules [e.g., ICAM-1, vascular cell adhesion molecule 1 (VCAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1)] if in contact with an activated endothelium could represent attractive targets for delivery of drugs and imaging probes to vascular pathological sites. The present study was designed to investigate, with morphological, immunochemical and immunohistochemical techniques, changes of heart and coronary arteries in Obese Zucker rats (OZR) compared to the lean Zucker rats (LZRs). The OZRs, with a mutation in leptin receptors, is a model of Type II diabetes mellitus, characterized by the presence of obesity, hyperglycemia, hyperinsulinemia, hyperlipidemia and moderate hypertension similar to MetS. The heart of OZRs of 12, 16 and 20 weeks was processed for microanatomical analysis and ICAM-1, VCAM-1 and PECAM-1 and pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) immunohistochemistry. OZRs at the different age, developed ventricular hypertrophy, characterized by increase size of cardiomyocytes but not fibrosis compared to LZRs. This phenomenon was more evident in 20-weeks-old OZRs. VCAM-1 was more expressed in the coronary arteries compared to other adhesion molecules, and increased in the OZRs of 20-weeks of age. In the same age, IL-6 expression was significantly increased. These results suggest that the obesity leads to heart tissue changes and coronary inflammation. Myocardial vascular inflammation, induced by metabolic comorbidities, could contribute to the development of heart failure. Protective strategies in obesity may be focussed versus body weight loss and countering of metabolic alterations induced by obesity.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
sj-docx-1-pie-10.1177_09544089231205778 - Supplemental material for Mechanical and microstructural characteristics of AA6082 using thermal equal channel angular pressing for structural applications
Creators: name: Kadiyan, Sunil
name: Kumar, Parveen
name: Goyat, Vikas
name: Ghangas, Gyander
name: Dehiya, BS
name: Prakash, Chander
Publisher: name: SAGE Journals
Year: 2023
Subjects: Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental material, sj-docx-1-pie-10.1177_09544089231205778 for Mechanical and microstructural characteristics of AA6082 using thermal equal channel angular pressing for structural applications by Sunil Kadiyan, Parveen Kumar, Vikas Goyat, Gyander Ghangas, BS Dehiya and Chander Prakash in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Expression of the estrogen and relaxin receptors in human fascial tissue
Creators: name: Albertin, Giovanna
name: Fede, Caterina
name: Petrelli, Lucia
name: Sfriso, Maria Martina
name: Incendi, Damiana
name: Biz, Carlo
name: De Caro, Raffaele
name: Stecco, Carla
Publisher: name: Firenze University Press
Year: 2017

description: Fascia is a tissue that interact with different structure in a very precise manner. It creates a structural continuity that give form and function to every tissue and organ. It plays a significant role in mechanical tension, transmitting force, correct motor coordination so altered structure of specific components layers could be generate a clinical problem. Recent studies have shown the possible role of the fascial nociceptors to mechanical and chemical stimuli may contribute to myofascial or musculoskletal pain (1). Many epidemiologic, clinical, and experimental evidence points to sex differences in myofascial pain, and generally adult women more often have myofascial problems than do men (2). It is possible that one of the stimuli to sensitization of fascial nociceptors could come from hormonal factors such as estrogen and relaxin that are involved in extracellular matrix and collagene remodelling (3). Relaxin-2 (RLX-2) is recognized as anti-fibrotic factor that is the ligand for RXFP1. Estrogens and in particular 17β-estradiol (E2) regulate a widespread of physiological functions and the actions are mediated by two estrogen receptor isoforms, ERα and ERβ. We hypothesized that E2 and relaxin contribute on metabolism and function of myofascial tissue. Immunohistochemical and molecular investigation (real-time PCR analysis) for RXFP1 and ERα localization were carried out in human fascia of different districts (peroneal, abdomen rectum, hip and low back fascia) and in fibroblasts isolated from the same districts, with the aim of describing both protein and RNA expression. ERα and RXFP1 are expressed on fibroblasts of human fascial tissues and RXFP1 expression was particular intense on vessels and nerves. These results are confirmed in isolated fibroblasts derived from the same fascial districts. Not all the cells have the same reactivity but the positive reaction was evident in the cytoplasm of cells for RXFP1 and with more intensity on nuclei of cells for ERα. Our results are the first demonstration that the fibroblasts of different districts of the muscular fasciae express sex hormone receptors. These findings could represent a new target for the care of myofascial pain and the possible stimulation during manipulative treatments and exercises. More studies about the interactions between fibroblasts, extracellular matrix and hormone receptors (estrogen, progesteron, relaxin) could help to understand the role of these receptors on myofascial pain.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
title: Historisierung des Europäischen Konvents
Creators: name: Mittergeber, Eva
Year: 2008

description: Die vorliegende Diplomarbeit verfolgt das Ziel, den Europäischen Konvent, der vom 28. Februar 2002 bis zum 10. Juli 2003 in Brüssel stattfand, in einen historischen Kontext zu setzen und einen Vergleich mit anderen, großteils nationalen verfassunggebenden Versammlungen, zu präsentieren. Ich richte meine Aufmerksamkeit dabei auf in Europa stattfindende verfassunggebende Versammlungen, wobei der Anfangspunkt meines Längsschnittes die französische Nationalversammlung von 1789/91 darstellt. Meine Diplomarbeit beginnt mit einem Definitionsteil, der sich einerseits mit der Frage nach den Grenzen Europas und dem Wesen der Europäischen Union auseinandersetzt und andererseits den Versuch unternimmt, Verfassungsbegriffe zu bestimmen. Im zweiten Teil der Arbeit konzentrieren sich meine Untersuchungen auf die Gestaltung verfassunggebender Versammlungen, wie sie seit 1789/91 in Frankreich, Deutschland und dem Habsburgerreich stattgefunden haben. Im dritten Teil widme ich mich den Verfassungsdiskussionen in der EG (später EU) und unternehme eine detaillierte Analyse des Grundrechtekonvents von 1999/2000 und des Europäischen Konvents von 2002/03.
description: My diploma thesis, entitled Historicisation of the European Convention. Constituent Assemblies in Europe - from the French National Assembly 1789/91 to the European Convention 2002/03, attempts to investigate the state of the European Convention, which took place in Brussels from 28th February 2002 until 10th July 2003, in the history of constituent assemblies in Europe beginning with the meetings of the French National Assembly, which held its meeting between 1789 and 1791. The first chapter presents definitions concerning the boarders of Europe and the European Union and closely elaborates the term "constitution". The second chapter concentrates on the analysis of the constituent assemblies in France, Germany and the Habsburg Empire. The focus of the third chapter will be on the discussions about a European constitution for the European Community (eventually European Union) and gives a detailed analysis of the genesis of the Charter of Fundamental Rights of the European Union and the organisation of the European Convention.
Partage des données de recherche de manière FAIR et en « open access »
Creators: name: Lebrand, Cécile
Publisher: name: Zenodo
Year: 2025
Subjects: Fair Data Sharing
Horus Dataset Catalog CHUV
Data Stewardship
ORD

description: Présentation sur le FAIR Data Sharing au CHUV dans le cadre des cours "L’essentiel pour mener votre recherche sur les données cliniques" organisé par le Centre de Recherche Clinique (CRC), avec le soutien de la Direction de l’innovation et de la recherche clinique (DIRC) et le Décanat de la FBM, organise une formation autour de la gestion de données de recherche clinique. 

Elle est destinée à tous/toutes les professionnel·le·s de la santé impliqué·e·s dans la gestion de données de recherche. Cette formation vous permet de :

Connaître les soutiens et outils disponibles dans l’institution

Maîtriser les outils informatiques

Appliquer les bonnes pratiques en termes de gestion des données en recherche

Gagner du temps et de l’autonomie dans la préparation de vos études

La formation théorique a été approuvée par l'institut suisse pour la formation (ISFM)/la FMH. Les personnes ayant suivi les 2 sessions théoriques de deux heures pourront obtenir 4 crédits ISFM. Elle peut être complétée par 5 ateliers pratiques facultatifs.
description: Public Record with Restricted Files.

The record is publicly accessible, but access to the associated files is restricted. Files can only be accessed by users who have been granted permission following validation by the scientific committee. For more details, please refer to the guidelines on how to request access to the dataset.

To get access to the dataset, please contact the following email:

cecile.lebrand@chuv.ch
description: CHUV

Contact email for dataset:

cecile.lebrand@chuv.ch
Generation of spheroids from human primary myofibroblasts: an experimental system to study myofibroblasts deactivation
Creators: name: Granato, Giuseppina
name: Ruocco, Maria Rosaria
name: Masone, Stefania
name: Calì, Gaetano
name: Iaccarino, Antonino
name: Di Spigna, Gaetano
name: Montagnani, Stefania
name: Arcucci, Alessandro
Publisher: name: Firenze University Press
Year: 2017
Subjects: Myofibroblasts; spheroids; deactivation

description: Fibroblasts represent a heterogeneous cell population, that in adult body maintains the homeostasis of the extracellular matrix (ECM) and can acquire an immunoregulatory phenotype. Indeed, activated fibroblasts produce large amounts of cyclooxygenase-2 (COX-2) and proinflammatory cytokines (1). The activation of fibroblasts is represented by their differentiation into myofibroblasts. This process, either in wound healing or cancer tissue, is associated with the expression of alpha-smooth muscle actin (alpha-SMA), increased levels of growth factors and ECM-degrading proteases (2). Moreover, myofibroblasts form clusters in wound healing process and hypertrophic scars. In particular, cell clusters of hypertrophic scars are represented by nodules of myofibroblasts (3). It is known that human dermal fibroblasts established from neonatal foreskin, and forced in vitro to form clusters named spheroids, are activated to produce massive amounts of COX-2, prostaglandins and proinflammatory cytokines: this process leads to a programmed necrosis, designated “nemosis” (1). In the present study we generated spheroids from human primary myofibroblasts of skin, to evaluate necrotic, inflammation and activation markers during myofibroblasts clustering. Western blotting analysis, showing low levels of COX-2 and a significant decrease of alpha-SMA in protein extracts of spheroids, led to hypothesize that myofibroblasts have undergone a deactivation process within spheroids. This hypothesis is confirmed by cytostatic effect exerted by spheroids conditioned medium on both normal and cancer cell lines, by confocal immunofluorescence analysis of connexin 43 and immunohistochemical evaluation of proliferation marker Ki-67. This work could represent an experimental model to study myofibroblasts deactivation and highlights an alternative process regulating the turnover of myofibroblasts.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Partage des données de recherche de manière FAIR et en « open access »
Creators: name: Lebrand, Cécile
Publisher: name: Zenodo
Year: 2025
Subjects: Fair Data Sharing
Horus Dataset Catalog CHUV
Data Stewardship
ORD

description: Présentation sur le FAIR Data Sharing au CHUV dans le cadre des cours "L’essentiel pour mener votre recherche sur les données cliniques" organisé par le Centre de Recherche Clinique (CRC), avec le soutien de la Direction de l’innovation et de la recherche clinique (DIRC) et le Décanat de la FBM, organise une formation autour de la gestion de données de recherche clinique. 

Elle est destinée à tous/toutes les professionnel·le·s de la santé impliqué·e·s dans la gestion de données de recherche. Cette formation vous permet de :

Connaître les soutiens et outils disponibles dans l’institution

Maîtriser les outils informatiques

Appliquer les bonnes pratiques en termes de gestion des données en recherche

Gagner du temps et de l’autonomie dans la préparation de vos études

La formation théorique a été approuvée par l'institut suisse pour la formation (ISFM)/la FMH. Les personnes ayant suivi les 2 sessions théoriques de deux heures pourront obtenir 4 crédits ISFM. Elle peut être complétée par 5 ateliers pratiques facultatifs.
description: Public Record with Restricted Files.

The record is publicly accessible, but access to the associated files is restricted. Files can only be accessed by users who have been granted permission following validation by the scientific committee. For more details, please refer to the guidelines on how to request access to the dataset.

To get access to the dataset, please contact the following email:

cecile.lebrand@chuv.ch
Additional file 6 of Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy
Creators: name: Kitahara, Yoshihiro
name: Inoue, Yusuke
name: Yasui, Hideki
name: Karayama, Masato
name: Suzuki, Yuzo
name: Hozumi, Hironao
name: Furuhashi, Kazuki
name: Enomoto, Noriyuki
name: Fujisawa, Tomoyuki
name: Funai, Kazuhito
name: Honda, Tetsuya
name: Misawa, Kiyoshi
name: Miyake, Hideaki
name: Takeuchi, Hiroya
name: Inui, Naoki
name: Suda, Takafumi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 6: Table S2. Clinical characteristics of patients with drug-induced interstitial lung disease caused by post-ICI antineoplastic therapy (N = 14).
Histopathological rearrangements of the colonic wall following dopaminergic nigrostriatal neurodegeneration
Creators: name: Ippolito, Chiara
name: Segnani, Cristina
name: Pellegrini, Carolina
name: Fornai, Matteo
name: Antonioli, Luca
name: Colucci, Rocchina
name: Dini, Sauro
name: Errede, Mariella
name: Virgintino, Daniela
name: Dolfi, Amelio
name: Bernardini, Nunzia
Publisher: name: Firenze University Press
Year: 2017
Subjects: Parkinson’s disease; experimental dopaminergic nigrostriatal neurodegeneration; colonic rearrangement

description: Parkinson’s disease (PD) is a degenerative neurological disorder, which is often associated with gastrointestinal disturbances (e.g., constipation and defecatory dysfunctions), whose mechanisms are still unknown [1]. Recently, an inflammatory pathogenesis has been proposed to explain these colonic disorders, but low literature are available. This study aims to analyze whether the central dopaminergic denervation, induced by intranigral injection of 6-hydroxydopamine (6-OHDA), can alter the morphological arrangement of colon in rats. Animals were euthanized 4 and 8 weeks after 6-OHDA injection. Histological, histochemical and immunohistochemical analysis were carried out on formalin-fixed, paraffin-embedded colonic samples in order to evaluate: histology, inflammatory cells (eosinophils and mast cells) and collagen fibers in the whole wall; glial fibrillary acidic protein (GFAP), immunoperoxidase, alpha-smooth muscle actin (alpha-SMA) and vimentin immunofluorescence by confocal microscopy. Malondialdehyde (MDA, colorimetric assay), TNF and IL-1β (ELISA assay) levels were also examined. 6-OHDA-induced nigrostriatal denervation was associated with the following histopathological changes observed in the colonic wall: eosinophil and mast cell infiltration, collagen deposition, activation of myenteric glial cells (GFAP+), increased vimentin immunostaining associated with alpha-SMA decrease in the tunica muscularis, enhanced colonic tissue levels of MDA, TNF and IL-1β. On the basis of the present results it is possible to conclude that the induction of central nigrostriatal dopaminergic denervation is followed by inflammation and fibrotic rearrangement of the colonic wall.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Chemical evolution of an evaporating lava pool
Creators: name: Curry, Alfred
name: Mohanty, Subhanjoy
name: Owen, James E.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Many known rocky exoplanets are so highly irradiated that their dayside surfaces are molten, and `silicate atmospheres', composed of rock-forming elements, are generated above these lava pools. The compositions of these `lava planet' atmospheres are of great interest because they must be linked to the composition of the underlying rocky interiors. It may be possible to investigate these atmospheres, either by detecting them directly via emission spectroscopy or by observing the dust tails which trail the low mass `catastrophically evaporating planets'. In this work, we develop a simple chemical model of the lava pool--atmosphere system under mass loss, to study its evolution. Mass loss can occur both into space and from the day to the nightside. We show that the system reaches a steady state, where the material in the escaping atmosphere has the same composition as that melted into the lava pool from the mantle. We show that the catastrophically evaporating planets are likely to be in this evolved state. This means that the composition of their dust tails is likely to be a direct trace of the composition of the mantle material that is melted into the lava pool. We further show that, due to the strength of day-to-nightside atmospheric transport, this evolved state may even apply to relatively high-mass planets (>1 Earth Mass). Moreover, the low pressure of evolved atmospheres implies that non-detections may not be due to the total lack of an atmosphere. Both conclusions are important for the interpretation of future observations.
description: Accepted for publication in MNRAs. 19 pages, 15 figures
title: Die Reaktionen der Bevölkerung auf den frühen Automobilismus in Österreich
Creators: name: Czabaun, Jutta
Year: 2008

description: Ende des 19. Jahrhunderts kam es mit der Entwicklung des Automobils zu einer bahnbrechenden Erfindung, die das Leben der Menschen bis heute entscheidend veränderte. Die Geschichte dieser ersten Fahrzeuge ist von Faszination, aber auch von Konflikten geprägt. Die positive Einstellung der nicht motorisierten Bevölkerung in der österreichischen Monarchie gegenüber dem neuen Gefährt änderte sich mit zunehmender Anzahl der Automobilisten und führte zu wiederholten Protestaktionen. Um die Reaktionen und Gründe zu verstehen, die die Menschen veranlassten, diese neuen Gefährte zu befürworten oder abzulehnen, gibt diese Arbeit einen Überblick über die technischen Erfindungen und deren Auswirkungen. Sie zeigt die Parallelen auf, mit denen bereits die Kutschen und RadfahrerInnen zu kämpfen hatten und begleitet die ersten Automobilisten auf ihren umstrittenen und erlebnisreichen Fahrten. Die Beiträge in den frühen Automobilzeitschriften, in verschiedenen Tages- und Wochenzeitungen, wie zum Beispiel in der Wiener Nähmaschinen und Velocipede Zeitung, im Humoristischen Wochenblatt Figaro, in der Zeitschrift Der Chauffeur, aber auch in Reisebeschreibungen, in automobilistischen Handbüchern sowie in Schriften intellektueller Automobilkritiker spiegeln die Entwicklungen, Wahrnehmungen und Interessen der wenigen Automobilbesitzer und der nicht automobilen Öffentlichkeit wider und stellen somit einen wesentlichen Teil der Quellen dieser Arbeit dar.
Investigating Graph Neural Networks and Classical Feature-Extraction Techniques in Activity-Cliff and Molecular Property Prediction
Creators: name: Dablander, Markus
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Biomolecules (q-bio.BM)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Molecular featurisation refers to the transformation of molecular data into numerical feature vectors. It is one of the key research areas in molecular machine learning and computational drug discovery. Recently, message-passing graph neural networks (GNNs) have emerged as a novel method to learn differentiable features directly from molecular graphs. While such techniques hold great promise, further investigations are needed to clarify if and when they indeed manage to definitively outcompete classical molecular featurisations such as extended-connectivity fingerprints (ECFPs) and physicochemical-descriptor vectors (PDVs). We systematically explore and further develop classical and graph-based molecular featurisation methods for two important tasks: molecular property prediction, in particular, quantitative structure-activity relationship (QSAR) prediction, and the largely unexplored challenge of activity-cliff (AC) prediction. We first give a technical description and critical analysis of PDVs, ECFPs and message-passing GNNs, with a focus on graph isomorphism networks (GINs). We then conduct a rigorous computational study to compare the performance of PDVs, ECFPs and GINs for QSAR and AC-prediction. Following this, we mathematically describe and computationally evaluate a novel twin neural network model for AC-prediction. We further introduce an operation called substructure pooling for the vectorisation of structural fingerprints as a natural counterpart to graph pooling in GNN architectures. We go on to propose Sort & Slice, a simple substructure-pooling technique for ECFPs that robustly outperforms hash-based folding at molecular property prediction. Finally, we outline two ideas for future research: (i) a graph-based self-supervised learning strategy to make classical molecular featurisations trainable, and (ii) trainable substructure-pooling via differentiable self-attention.
description: Doctoral Thesis (Mathematical Institute, University of Oxford)
sj-pdf-1-smm-10.1177_09622802231206477 - Supplemental material for Random survival forests with multivariate longitudinal endogenous covariates
Creators: name: Devaux, Anthony
name: Helmer, Catherine
name: Genuer, Robin
name: Proust-Lima, Cécile
Publisher: name: SAGE Journals
Year: 2023
Subjects: Health and Community Services
Nursing not elsewhere classified
Sociological Methodology and Research Methods

description: Supplemental material, sj-pdf-1-smm-10.1177_09622802231206477 for Random survival forests with multivariate longitudinal endogenous covariates by Anthony Devaux, Catherine Helmer, Robin Genuer and Cécile Proust-Lima in Statistical Methods in Medical Research
sj-docx-2-hss-10.1177_15563316231207632 – Supplemental material for Telemedicine Use Following Onset of the COVID-19 Pandemic Was Associated With Youth and White Race but Not With Socioeconomic Deprivation: A Retrospective Cohort Study of Orthopedic Patients
Creators: name: Navarro, Brendan J.
name: Chen, Ling
name: Dy, Christopher J.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Surgery

description: Supplemental material, sj-docx-2-hss-10.1177_15563316231207632 for Telemedicine Use Following Onset of the COVID-19 Pandemic Was Associated With Youth and White Race but Not With Socioeconomic Deprivation: A Retrospective Cohort Study of Orthopedic Patients by Brendan J. Navarro, Ling Chen and Christopher J. Dy in HSS Journal®
PairSonic: Helping Groups Securely Exchange Contact Information
Creators: name: Putz, Florentin
name: Haesler, Steffen
name: Völkl, Thomas
name: Gehring, Maximilian
name: Rollshausen, Nils
name: Hollick, Matthias
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cryptography and Security (cs.CR)
subject: Human-Computer Interaction (cs.HC)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Securely exchanging contact information is essential for establishing trustworthy communication channels that facilitate effective online collaboration. However, current methods are neither user-friendly nor scalable for large groups of users. In response, we introduce PairSonic, a novel group pairing protocol that extends trust from physical encounters to online communication. PairSonic simplifies the pairing process by automating the tedious verification tasks of previous methods through an acoustic out-of-band channel using smartphones' built-in hardware. Our protocol not only facilitates connecting users for computer-supported collaboration, but also provides a more user-friendly and scalable solution to the authentication ceremonies currently used in end-to-end encrypted messengers like Signal or WhatsApp. PairSonic is available as open-source software: https://github.com/seemoo-lab/pairsonic
description: 3 pages, 1 figure, the source code is available at https://github.com/seemoo-lab/pairsonic and a demo video is available at https://www.youtube.com/watch?v=e1AMYDLWN0E and further project information is at https://fputz.net/pairsonic
Renal cell carcinoma in young with distant metastasis,  a case report
Creators: name: Karki, Suman
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Abdomen
subject: Kidney
subject: CT
subject: Diagnostic procedure
subject: Metastases
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 14 years
description: Clinical History: This is a case of 13 years old female with flank pain and abdominal distention. Final Diagnosis: Renal cell carcinoma with liver and lung metastasis