cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inflammatory markers and prediction of death in type 2 diabetes. Proof of an intertwined link with tryptophan metabolism
Creators: name: Menzaghi, Claudia
name: Marucci, Antonella
name: Mastroianno, Mario
name: Di Ciaccia, Giulio
name: Pia Armillotta, Maria
name: Prehn, Cornelia
name: Salvemini, Lucia
name: Mangiacotti, Davide
name: Adamski, Jerzy
name: Fontana, Andrea
name: Cosmo, Salvatore De
name: Lamacchia, Olga
name: Copetti, Massimiliano
name: Trischitta, Vincenzo
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420299
subject: Epidemiology not elsewhere classified

description: In this article we describe, for the first time, a strong and independent association between six biologically plausible inflammatory markers (i.e., IL-4, IL-6, IL-8, IL-13, RANTES and IP-10) and their derived inflammation score (I-score) and increased mortality risk in patients with type 2 diabetes.Notably, our data show that the addition of the I-score on top of two 2 well-known clinical prediction models of mortality in patients with diabetes, improves discrimination measures by values much higher than the threshold requested by clinical guidelines for adding novel biomarkers to established prediction models. Such improvement is paired by the ability to reclassify a consistent proportion of individuals, both among events and non-events.In addition, we explored by epidemiological and in vitro studies the role of inflammation and its relationship with tryptophan metabolism in shaping death risk. Our data confirm a relationship between inflammation and tryptophan metabolism in shaping mortality risk and may pave the way for new therapies targeted at subgroups of patients characterized by increased low-grade inflammation and imbalanced tryptophan metabolism.Our study belongs to those efforts needed for turning precision medicine (i.e., precision prediction) into reality. Indeed, we believe that the implementation of our findings in the real-life clinical setting can help the entire diabetes community, including patients, their families and their caregivers.
High-throughput Cell Encapsulation in Monodisperse Agarose Microcapsules Using a Microfluidic Device
Creators: name: Monette-Catafard, Nicolas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Microfluidics
Microcapsules
Cell encapsulation
Agarose
Cell therapy
Regenerative medicine
Lab-on-a-chip

description: Over the last decade, microfluidics has emerged as a distinct new field with promising applications for diverse research areas. The ability to precisely control fluids at the microscale allows the execution of a variety of programmable semi-automatic operations on the same device, effectively forming a lab-on-a-chip. In particular, droplet-based microfluidic systems – which reliably generate highly uniform microdroplets at a high throughput – enable the controlled compartmentalization of biological material and have the potential to influence mainstream biomedical research. In this thesis, a microfluidic platform is presented that allows the encapsulation of viable cells in agarose microcapsules for applications in cell–based therapy. As an improvement to pre-existing methods of cell encapsulation, the proposed system combines continuous high throughput cell-encapsulation with on-chip microcapsule gelation and purification.
Effects of chronic and state loneliness on heart rate variability in women
Creators: name: Roddick, Charlotte
name: Chen, Frances S.
Publisher: name: Oxford University Press
Year: 2021

description: Background Loneliness, the subjective experience of social isolation, represents one of the largest risk factors for physical illness and early death in humans. However, the mechanisms by which loneliness leads to adverse health outcomes are not well understood. Purpose In this study, we examined altered parasympathetic nervous system function as a potential pathway by which chronic loneliness and state loneliness may “get under the skin” to impact cardiovascular physiology. Methods In a controlled laboratory setting, vagally-mediated resting heart rate variability (HRV), HRV reactivity to an induction of state loneliness, and HRV reactivity to a cognitive challenge task were assessed in a sample of 316 healthy women (18–28 years). Results Greater chronic loneliness in women predicted lower resting HRV, an independent risk factor for cardiovascular disease and all-cause mortality, after controlling for demographic, psychosocial, and health behavior covariates. Furthermore, women higher in chronic loneliness experienced significantly larger increases in HRV to state loneliness and reported significantly higher levels of negative affect immediately following state loneliness, compared to their less chronically lonely counterparts. Chronic loneliness also predicted blunted HRV reactivity—a maladaptive physiological response—to cognitive challenge. Conclusions The current findings provide evidence that chronic loneliness is associated with altered parasympathetic function (both resting HRV and HRV reactivity) in women, and that the immediate experience of state loneliness is linked to a proximate increase in HRV among chronically lonely women. Results are discussed in terms of implications for cardiovascular health and the evolutionary functions of loneliness.
Positive and Negative Support Roles in the Social Networks of Vulnerable People
Creators: name: Aglipay, Mary M. O.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: social networks
HIV/AIDS
sexually transmitted infections
drug behavior
crack smoking
injection drug use
interpersonal relations
condom use
social support
homeless persons
prostitution
marginalization
tie strength
infectious diseases
friendship networks

description: Introduction: Social networks have shown promise in curbing drug dependency and infectious diseases among marginalized populations. The purpose of this study is to elucidate how relationship strength in social networks is associated with risk behaviours for infectious diseases. Methods: Two reviews were conducted: 1) a systematic review exploring the association between risk behaviours and relationship strength 2) a review on the utilization of respondent driven sampling (RDS). We also analyzed network data to determine the association between recent injection drug use and recent crack use. Results: Our reviews revealed that few studies link relationship strength and risk behaviours; moreover, RDS is effective method of sampling from marginalized populations. Finally, our analysis demonstrated that close relationships are associated with drug use. Conclusion: “Close” relationships are important in arbitrating injection drug use and crack smoking. More research addressing the issues of using data from dynamic social processes and hard-to-reach populations is needed.
Role of Caspase 3/Caspase Activated DNase induced DNA Strand Breaks during Skeletal Muscle Differentiation.
Creators: name: Larsen, Brian D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Cell Differentiation
Caspase
Caspase-activated DNase
DNA strand breaks
Gene Expression
Cell Death

description: Cell fate decisions incorporate distinct and overlapping mechanisms. The activity of caspase 3 was initially understood to be a cell death restricted event, however numerous studies have implicated this enzyme in the regulation of both differentiation and proliferation. How the activity of caspase 3 promotes a non-death cell fate remains unclear. Here we examine the role caspase 3 activity plays during skeletal muscle differentiation; in particular we explore the hypothesis that the mechanism of inducing DNA strand breaks during cell death is also a key feature of differentiation, albeit with a distinctly different outcome. We delineate the transient formation of Caspase 3/Caspase activated DNase (CAD) dependent DNA strand breaks during differentiation. The formation of these breaks is essential for differentiation and the regulation of specific genes. In particular expression of the cell cycle inhibitor p21 is related to the formation of a DNA strand break within the gene’s promoter element. Further, we explored the genome wide association of CAD using Chromatin Immunoprecipitation coupled to high through put sequencing (ChIP-seq). This approach identified a potential role for Caspase3/CAD in regulating the expression of Pax7. Here, a CAD directed DNA strand break in the Pax7 gene is correlated with decreased Pax7 expression, an outcome that has been shown to be critical for progress of the myogenic differentiation program. The regulation of Pax7 expression through a CAD induced DNA strand break raises an intriguing connection between this regulation and oncogenic transformation observed in alveolar rhabdomyosarcoma. The putative site of CAD induced DNA strand breaks that promote decreased Pax7 expression during differentiation corresponds to site of chromosomal translocations responsible for Pax7 fusion events in alveolar rhabdomyosarcoma.
Additional file 1 of Bridging different realities - a qualitative study on patients’ experiences of preoperative care for benign hysterectomy and opportunistic salpingectomy in Sweden
Creators: name: Collins, Elin
name: Lindqvist, Maria
name: Mogren, Ingrid
name: Idahl, Annika
Publisher: name: figshare
Year: 2020
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. : Interviewguide.pdf, semi-structured interview guide used as a data collection tool.
A Novel Photo-labile Caged Peptide for the Repairment of Spinal Cord Injuries
Creators: name: Lu, Chunyu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Caged Peptide
Cyclic Caging
Photo-labile Peptide

description: Spinal cord injuries (SCI) are characterized by the inability of mature neurons to regenerate or repair by themselves. In an attempt to overcome the SCI, a novel photo-sensitive cyclic Arg-Gly-Asp-Ser (RGDS) peptide was synthesized using solid phase peptide synthesis (SPSS) to control 3T3 fibroblast cell attachment on hyaluronic acid (HA) hydrogel. The circular RGDS peptide was designed using RGDS sequence labeled with Anp group (3-Na-fmoc-amino-3-(2-nitrophenyl) propionic acid) at the N terminus. The peptide was photo-labile cyclic caged to shelter its bioactivity and UV light was used to make the peptide uncaged. Accuracy of the cyclic caged RGDS peptide was confirmed by high-performance liquid chromatography (HPLC) and mass spectrum (MS). The molecular weight of cyclic caged RGDS peptide was confirmed as 881 by matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) mass spectrum. Stability of the cyclic caged RGDS peptide under various pH conditions was verified by circular dichroism spectroscopy. The bioactivity of cyclic caged and uncaged RGDS peptide was tested by photo-controllable directing cell growth based on cell attachment study, cell counting study, and cell morphology study. Three dimensional model structures of cyclic caged and uncaged RGDS peptides were computed by Hyperchem program. The first order reaction theory of Anp uncaging reaction was confirmed by kinetic study. Bioactivity caging and uncaging property of the peptide was also fully confirmed by cell attachment study. This cyclic caged RGDS peptide would be a promising tool in cell patterning for repairing of SCI.
Additional file 2 of Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan
Creators: name: Yoshioka, Wakako
name: Miyasaka, Naoyuki
name: Okubo, Ryo
name: Shimizu, Reiko
name: Takahashi, Yuji
name: Oda, Yuriko
name: Ichizo Nishino
name: Harumasa Nakamura
name: Mori-Yoshimura, Madoka
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 2.
title: Study of Cathodoluminescence in Semiconductors
Creators: name: Kale, Mandakini V.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1991

description: Cathodoluminescence in Zn doped GaAs and ZnSe, the materials of interest for electron-beam controlled semiconductor switches, has been investigated. A new diagnostic technique, using telescopic setup of lenses, was developed to study the spatially resolved cathodoluminescence. The setup eliminated the light, other than rays from the sample, parallel to the optical axis, resulting in an enhanced spatial resolution. At high e-beam energies, light was detected, from the Zn layer region in the GaAs. It is proposed to be due to the radiative recombination of electron-hole pairs, created by the e-beam. For the polycrystalline ZnSe no light emission was detected. This was possibly due to the crystal defects present in the material, resulting in non-radiative recombination of the electron-hole pairs. The internal quantum efficiency of the Zn doped GaAs was calculated, and was compared with results obtained from previous modeling studies.
Neuroelectrical Investigations Into the Sensory and Cognitive Effects of Nicotine and Monoamine Oxidase Inhibition in Humans
Creators: name: Smith, Dylan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Smoking
EEG
Monoamine Oxidase
Schizophrenia
Nicotine
Event-Related Potential

description: Investigations into the cognitive effects of tobacco smoking have generally focused on nicotine and its effect on nicotinic acetylcholine receptors (nAChRs) in the brain. However, it is now known that chronic smokers exhibit robust inhibition of the monoamine oxidase (MAO) enzyme through the actions of non-nicotine components in tobacco smoke. Therefore, the primary aim of this thesis is to elucidate the effects of nicotine and MAO-inhibition on electroencephalographic (EEG) and event-related potential (ERP) measures of cognition. 24 healthy nonsmoking males were administered 75 mg of moclobemide, and chewed 6 mg nicotine gum, in order to simulate the effects of acute smoking. Four experimental conditions included placebo, nicotine, moclobemide, and a combination of nicotine and moclobemide. Early auditory ERPs were used as measures of cognition, such as the auditory P50 sensory gating paired-stimulus paradigm, the acoustic-change-elicited mismatch-negativity (MMN), the novel sound-elicited P3a, and the target sound-elicited P3b. Three minutes of eyes closed EEG were also recorded. Because these ERPs are often identified as biomarkers for schizophrenia, drug effects were also measured after individuals were stratified for low-baseline amplitude of each ERP measure, as a laboratory model of cognitive deficits in schizophrenia. Overall results showed a synergistic improvement in sensory gating via nicotine combined with moclobemide, accompanied by a reduction in theta band power. Nicotine in the absence of moclobemide increased P3b amplitude, accompanied by an increase in alpha2 band power. Moclobemide in the absence of nicotine increased P3a amplitude, accompanied by a decrease in beta2 power. Stratifying participants by placebo amplitude revealed both nicotine and moclobemide exhibited an inverted-U pattern of effect, i.e. showing greater amplitude increases in individuals with the lowest baseline amplitudes. Overall, this thesis demonstrates how these two components of tobacco smoke affect different facets of auditory processing in different ways, with synergistic effects in some paradigms but antagonizing effects in others. Therefore, chronic smokers and schizophrenia patients who seek transient cognitive improvement through smoking may actually experience cognitive detriments overall, possibly contributing to withdrawal symptoms and/or an exacerbation of already-present psychiatric symptoms.
Social value creation in the impact of social entrepreneurship
Creators: name: Gillin, Loris
name: Hanich, Adolph
Publisher: name: Swinburne
Year: 2024

description: The laboratory for this research is seven non-profit social ventures. The topic of enquiry is: how can we better understand the way in which social value is created? Based on research into Boards, Volunteers and low-paid support staff, and the visionary Social Entrepreneurs themselves, seven CEOs were respondents to E(Entrepreneurship)- Indicators which amplify constructs from Entrepreneurship theory. A cross-venture analysis showed that while social entrepreneurs share aspects of major factors with regular for-profit entrepreneurs, they are also unique in how they perceive human need, express spirituality, and their non-regard for good luck.
Children and Youth Who Run Away from Substitute Care: A Qualitative and Quantitative Analysis
Creators: name: Byrne, Andrea M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: runaway
child welfare
foster care
substitute care
community psychology
strengths and needs
trauma
youth

description: Many homeless youth come from foster homes, group homes, and other forms of substitute care. For young people in the child welfare system, elopement represents a major problem as it places them at risk for a number of troubling outcomes. Three studies were undertaken examining elopement among young people living in substitute care in Canada and the United States. The first study explored strengths and needs in a sample of 5,011 children and youth housed in a variety of substitute care settings including foster homes, group homes, residential treatment centres, emergency shelters, and juvenile justice facilities. Results indicated that needs, but not strengths, predicted running among children, while both needs and strengths predicted running among adolescents. Problems with school attendance, substance abuse, and delinquency also predicted running among both children and adolescents, with the exception of young children, for whom substance abuse was not a significant predictor. The second study explored the relationship between trauma, strengths, and elopement in a sample of 2,296 adolescents living in substitute care. Sexual abuse, physical abuse, school violence, and traumatic grief/separation were found to predict elopement. In addition, family violence and community violence predicted running among younger but not older adolescents. Educational strengths predicted a lower risk of running away for all adolescents, while well-being and relationship permanence predicted a lower risk of running among younger and older adolescents, respectively. The impact of strengths on the relationship between trauma and elopement was evaluated, with results suggesting that elopement was not predicted by an interaction between strengths and trauma. The third study was qualitative in nature and explored the perspectives of youth who had run away from substitute care at least once in their lifetime. Youth provided information about their experiences as well as suggestions designed to reduce the prevalence of running away among youth in substitute care. Findings for all three studies were discussed in relation to the literature with implications for research and prevention.
Additional file 1 of Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan
Creators: name: Yoshioka, Wakako
name: Miyasaka, Naoyuki
name: Okubo, Ryo
name: Shimizu, Reiko
name: Takahashi, Yuji
name: Oda, Yuriko
name: Ichizo Nishino
name: Harumasa Nakamura
name: Mori-Yoshimura, Madoka
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 1.
Additional file 1 of Connecting communities to primary care: a qualitative study on the roles, motivations and lived experiences of community health workers in the Philippines
Creators: name: Mallari, Eunice
name: Lasco, Gideon
name: Sayman, Don Jervis
name: Amit, Arianna Maever L.
name: Balabanova, Dina
name: McKee, Martin
name: Jhaki Mendoza
name: Palileo-Villanueva, Lia
name: Renedo, Alicia
name: Seguin, Maureen
name: Palafox, Benjamin
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1. Topic guide for BHWs.
Gender, reproductive output covariation and their role on gene diversity of Pinus koraiensis seed orchard crops
Creators: name: Park, Ji-Min
name: Kang, Hye-In
name: Yeom, Da-Bin
name: Kang, Kyu-Suk
name: El-Kassaby, Yousry A.
name: Lee, Kyung-Mi
Publisher: name: BioMed Central
Year: 2020

description: Background: Gender and fertility variation have an impact on mating dynamics in a population because they affect the gene exchange among parental members and the genetic composition of the resultant seed crops. Fertility is the proportional gametic contribution of parents to their progeny. An effective number of parents, derivative of effective population size, is the probability that two alleles randomly chosen from the gamete gene pool originated from the same parent. The effective number of parents is directly related to the fertility variation among parents, which should be monitored for manipulating gene diversity of seed crops. We formulated a fundamental equation of estimating the effective number of parents and applied it to a seed production population. Results: Effective number of parents (Np) was derived from fertility variation (Ψ) considering covariance (correlation coefficient, r) between maternal and paternal fertility. The Ψ was calculated from the coefficient of variation in reproductive outputs and divided into female (ψf) and male (ψm) fertility variation in the population under study. The Np was estimated from the parental Ψ estimated by the fertility variation of maternal (ψf) and paternal (ψm) parents. The gene diversity of seed crops was monitored by Ψ and Np. in a 1.5 generation Pinus koraiensis seed orchard as a case of monoecious species. A large variation of female and male strobili production was observed among the studied 52 parents over four consecutive years, showing statistically significant differences across all studied years. Parental balance curve showed greater distortion in paternal than maternal parents. The Ψ ranged from 1.879 to 4.035 with greater ψm than ψf, and the Np varied from 14.8 to 36.8. When pooled, the relative effective number of parents was improved as 80.0% of the census number. Conclusions: We recommend the use of fertility variation (i.e., CV, Ψ), Person’s product-moment correlation (r), and effective number of parents (Np) as tools for gauging gene diversity of seed crops in production populations. For increasing Np and gene diversity, additional management options such as mixing seed-lots, equal cone harvest and application of supplemental-mass-pollination are recommended.
Young women, desire and heteronormativity: the relationship between sexual experience and the sexual double standard
Creators: name: Louth, Meg
Publisher: name: Swinburne
Year: 2024

description: A heteronormative discourse often assumes that men want sex and women want love (Bryant & Schofield 2007). It assumes gender structures sexuality in distinctly masculine and feminine ways and appropriate behaviours are defined according to these gender structures. This discourse fails to acknowledge the complexities of contemporary sexualities and positions women as passive and men as active which eliminates the need for negotiation in sexual relationships. Through analysis of in-depth interviews with women aged 22-31, this study sought to identify young women's perceptions of how accumulated sexual experience mediates the sexual double standard and to what extent they believe it influences their sexual relationships. It also explored women's subjective experiences of sexual agency, sexual pleasure and sexual desire. There is very little Australian sociological research that explores the accumulation of sexual experiences for women beyond school age and this thesis addressed this gap in the literature. Above all, this research will argue that the participants' experiences of sex and sexuality are complex and contradictory. The results suggest that, for the women in this study, accumulated sexual experience influences young women's subjective experience of sexual agency, desire and pleasure. It will also argue that women face many challenges in expressing their agency desire and pleasure within the dominant discourse of heteronormativity.
Féminisme du care et féminisme autochtone: une approche phénoménologique de la violence en Occident
Creators: name: Perreault, Julie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Théories féministes
Éthique du care
Amour
Tragique
Femmes Autochtones - Amérique du Nord
Carol Gilligan

description: Cette thèse explore la problématique de la violence à travers deux corpus distincts : le féminisme du care et le féminisme autochtone, principalement nord-américain. S’inspirant des travaux de Carol Gilligan en psychologie morale et sociale, ses propos démontrent l’existence d’un fil conducteur entre la répétition d’une « psychologie de la dissociation », en Occident, et la forme de vie patriarcale qui la définit. Le dialogue avec le féminisme autochtone nous permet de saisir de nouvelles articulations matérielles et politiques de cette violence à travers l’expérience de la colonisation. En parallèle avec le care, le féminisme autochtone nous permet aussi de concevoir de nouvelles formes de résistance éthique, épistémologique et politique à cette violence. L’introduction pose le problème de la thèse autour de la violence, de la théorie politique et du féminisme. Le premier chapitre discute des tabous et des difficultés qui entourent encore aujourd’hui les théories féministes, incluant les deux corpus étudiés. Le deuxième chapitre discute de l’évolution des débats sur le care et les travaux de Carol Gilligan depuis les années 1980 jusqu’à aujourd’hui. Coeur de la thèse, le troisième chapitre présente la critique de la violence patriarcale telle que Gilligan l’articule dans ses travaux les plus récents. Il s’ouvre ainsi sur une critique de l’amour tragique et des considérations de genre qui en constituent le centre. Le quatrième chapitre discute enfin plus en profondeur du féminisme autochtone. Ses enjeux sont présentés en reprenant la méthode traditionnelle de la roue de la médicine. L’ensemble montre une approche critique, phénoménologique et thérapeutique sur l’enjeu de la violence qui nous préoccupe.
Additional file 5 of Developmentally regulated activation of defense allows for rapid inhibition of infection in age-related resistance to Phytophthora capsici in cucumber fruit
Creators: name: Mansfeld, Ben N.
name: Marivi Colle
name: Chunqiu Zhang
name: Ying-Chen Lin
name: Grumet, Rebecca
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Supplementary file 5. All code and analysis
Emissionsbilanz erneuerbarer Energieträger 2020
Creators: name: Lauf, Thomas
name: Memmler, Michael
name: Schneider, Sven
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Emissionsbilanz
subject: Emissionsminderung
subject: Lebenszyklus
subject: Emissionsbilanzierung
subject: Erneuerbare Energien
subject: Emissionsvermeidung
subject: Lebenszyklusanalyse
subject: Emissionsfaktoren
subject: Substitutionsfaktoren
subject: Klima | Energie

description: Die in diesem Bericht aufgeführten Ergebnisse für das Jahr 2020 zeigen, dass der Ausbau erneuerbarer Energien wesentlich zur Erreichung der Klimaschutzziele in Deutschland beiträgt. Insgesamt werden in allen Verbrauchssektoren fossile Energieträger zunehmend durch erneuerbare Energien ersetzt und damit dauerhaft Treibhausgas- und Luftschadstoffemissionen vermieden. Die Ergebnisse zeigen darüber hinaus, dass eine differenzierte Betrachtung verschiedener Technologien und Sektoren sinnvoll und notwendig ist, wenn es z.B. darum geht, gezielte Maßnahmen zum Klimaschutz und der Luftreinhaltung abzuleiten, da sich die spezifischen Vermeidungsfaktoren für die untersuchten Treibhausgase und Luftschadstoffe teilweise erheblich unterscheiden. Im Ergebnis weist die Netto-Emissionsbilanz der erneuerbaren Energien unter Berücksichtigung der Vorketten eine Vermeidung von Treibhausgasemissionen in Höhe von rund 230 Mio. t CO2-Äquivalente (CO2-Äq.) im Jahr 2020 aus. Auf den Stromsektor entfielen 179 Mio. t CO2-Äq., davon sind 157 Mio. t der Strommenge mit EEG-Vergütungsanspruch zuzuordnen. Im Wärmesektor wurden 41 Mio. t und durch biogene Kraftstoffe 11 Mio. t CO2-Äq. vermieden. Quelle: www.umweltbundesamt.de
description: Die in diesem Bericht aufgeführten Ergebnisse für das Jahr 2020 zeigen, dass der Ausbau erneuerbarer Energien wesentlich zur Erreichung der Klimaschutzziele in Deutschland beiträgt. Insgesamt werden in allen Verbrauchssektoren fossile Energieträger zunehmend durch erneuerbare Energien ersetzt und damit dauerhaft ⁠Treibhausgas⁠- und Luftschadstoffemissionen vermieden. Die Ergebnisse zeigen darüber hinaus, dass eine differenzierte Betrachtung verschiedener Technologien und Sektoren sinnvoll und notwendig ist, wenn es z.B. darum geht, gezielte Maßnahmen zum ⁠Klimaschutz⁠ und der Luftreinhaltung abzuleiten, da sich die spezifischen Vermeidungsfaktoren für die untersuchten Treibhausgase und Luftschadstoffe teilweise erheblich unterscheiden. Im Ergebnis weist die Netto-Emissionsbilanz der erneuerbaren Energien unter Berücksichtigung der Vorketten eine Vermeidung von Treibhausgasemissionen in Höhe von rund 230 Mio. t ⁠CO2⁠ -Äquivalente (CO2-Äq.) im Jahr 2020 aus. Auf den Stromsektor entfielen 179 Mio. t CO2-Äq., davon sind 157 Mio. t der Strommenge mit EEG-Vergütungsanspruch zuzuordnen. Im Wärmesektor wurden 41 Mio. t und durch biogene Kraftstoffe 11 Mio. t CO2-Äq. vermieden.
Additional file 6 of Developmentally regulated activation of defense allows for rapid inhibition of infection in age-related resistance to Phytophthora capsici in cucumber fruit
Creators: name: Mansfeld, Ben N.
name: Marivi Colle
name: Chunqiu Zhang
name: Ying-Chen Lin
name: Grumet, Rebecca
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6.
Turning 'cold sellers' into 'must haves': marketing unsought library products
Creators: name: Badger, Julie
Publisher: name: Swinburne
Year: 2024

description: According to marketing theory unsought products are those that consumers do not know about, do not ever consider buying or have negative attitudes towards. Goods and services such as life insurance, pre-paid funerals and encyclopaedias require significant, ongoing marketing efforts if they are to be successful. This paper argues that many goods and services in academic libraries fall into the category of unsought products. Perhaps the most notable of our unsought products are the aggregated databases of journal articles. Their relative inaccessibility compared with public search engines, the complexity of use, and the sheer number of choices discourages many students and leads them to prefer competing information sources. The meaningless names of many databases have no brand recognition or equity likely to entice a browsing student to explore them further, and the search techniques needed to uncover the wealth of information within are often beyond the skill and motivation of the student. Many librarians are familiar with the concept of the marketing mix: the 4 Ps---Product, Price, Place and Promotion. Over the years we have made considerable adjustments to two of these elements, place and promotion, in attempting to reach our clients. There has been, for example, a concerted effort to take advantage of emerging technologies to engage the interest of the current generation of students. Most of our first year students have survived 12 years of education without using EBSCO. Why start now? What marketing strategies can librarians employ to turn 'cold sellers' into 'must haves'?
Development of Biomolecular Tools for Studying Host-Virus Interactions of the Hepatitis C Virus
Creators: name: Nasheri Ardekan, Neda
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Hepatitis C Virus
Activity-Based Protein Profiling

description: Hepatitis C virus (HCV) is a growing health concern in Canada and around the world, as it currently infects 3% of the global population. While there is no vaccine available against this virus, novel and effective treatment regimens have improved prospects for the cure of HCV. Complications caused by HCV can lead to severe liver disease and even death. The limited viral proteome forces HCV to rely heavily on various host factors for its replication. Additionally HCV modulates the host physiology to facilitate its pathogenesis; consequently, the in dept study of essential host-virus interactions expands our understandingof how the virus and related species commandere host cell machinery. This understanding can help create new therapeutic strategies, which may have applications towards HCV and other related RNA viruses. While numerous studies have demonstrated that HCV modulates the abundance of various host proteins, the systematic study of the virus’s effect on the enzymatic activity has been relatively unexplored. For this reason, activity-based protein profiling (ABPP) was applied to study the changes in the activity of host enzymes during HCV replication. ABPP is a functional proteomics technique that employs active site-directed probe (ABP) to report on the activity of enzymes within complex proteomes, such as living cells. Herein, directed and non-directed ABPs were employed for specific as well as global profiling of the alterations in the activity of cellular enzymes during HCV replication. As a result, essential host enzymes that are differentially active during HCV infection were identified. Furthermore, I have developed a quantitative ABPP method for relative quantification of the cellular enzymes activity during HCV infection. These results contribute to the discovery of disease-associated biomarkers, with diagnostic significance, and aid in the identification of potential targets for therapeutic interventions. In addition to developing protein-based tools to study host-virus interactions, I employed a novel technique to investigate the interactions of micro-RNA 122 (miR-122), an essential HCV host factor, with the viral RNA genome. This in vitro screening approach, interrogates the folding of HCV RNA using viral RNA-coated magnetic bead (VRB) to determine target site accessibility for RNA silencing. This method predicts the relative affinity of small RNAs towards HCV genomic RNA that are not easily predicted by informatic means, and led to discovery of potent miR-122 interaction site within the large, highly-structured HCV RNA genome. For that reason, VRB assay may represent an attractive tool for the examination of target site accessibility for RNA silencing.
Additional file 1 of Spatiotemporal behavior of a large-scale landslide at Mt. Onnebetsu-dake, Japan, detected by three L-band SAR satellites
Creators: name: Takada, Youichiro
name: Motono, George
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology

description: Additional file 1: Figure S1. Trajectories of three typhoons passing through Hokkaido in August 2016. Data are provided from JMA. Red line: Typhoon Chanthu. Gree line: Typhoon Mindulle. Blue line: Typhoon Kompasu. Circles with numbers indicate daily locations of the typhoon center at 9 AM (JST) and the date in August.
Seeking Inclusion In the 'Land of Broken Toys': Negotiating Mental Health Managerialism Among Homeless Men and Women
Creators: name: Dej, Erin Theresa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Homelessness
Mental health
Exclusion
Governing through Freedom

description: Mental health, homelessness, addiction, and criminalization are the usual suspects of exclusion. The connection between these factors are often taken for granted, with positivistic accounts of causality making up the bulk of the literature. Using an institutional ethnography framework, this study draws attention to how individuals make sense of their exclusion. In particular, in this research I examine how homeless men and women ‘do’ their mental health status. Exploring themes of responsibilization, exclusion, identity, performativity, hope, and resistance, this research highlights the ways in which homeless individuals use the mental health system and the mental illness identity to contextualize their circumstances and to demonstrate their redeemability. Stemming from thirty-eight interviews with homeless men and women, participant observation, as well as a focus group with professionals and para-professionals I consider how mental illness identities are negotiated and performed among homeless men and women. Specifically, I am interested in how homeless individuals engage with mental health managerialism, given their vulnerable status. I contend that while some individuals resist mental illness discourses to varying degrees, a number of homeless individuals adopt the role of mental health consumer so as to align with the broader consumer society. In so doing, many homeless men and women seek to position themselves as included among the excluded and thus privy to the sense of hope, empowerment, and privileges that follow.
title: Benton Harbor Smart Mobility Project Community Report
Creators: name: Goodspeed, Robert
name: Johnson, Aaron
name: Zou, Yiyun
Publisher: name: University of Michigan
Year: 2024
Subjects: subject: urban planning
subject: public transit
subject: scenario planning
subject: Urban and Regional Planning
subject: FOS: Social and economic geography
subject: Architecture
subject: FOS: Civil engineering
subject: Arts

description: Residents of many American communities face mobility challenges reaching everyday destinations, such as workplaces, schools, medical offices and grocery stores. In these communities, public transportation systems provide a vital lifeline for their communities, but communities often lack the resources, methodologies, and capacity to undertake improvements to these systems. The objective of this project was to research how under-resourced communities can utilize smart and connected community technologies to implement novel but lean solutions to improve long-standing community mobility challenges. The project team investigated this topic through a multi-faceted engagement with the community of Benton Harbor, Michigan, including the city’s public transit provider, the Twin Cities Area Transportation Authority, and many community residents and stakeholders. Project activities fell into three general categories: 1. The collection and analysis of data from multiple sources: resident travel surveys, rider and stakeholder interviews, transit system administrative logs, and transit vehicle tracking; 2. The creation of analysis, modeling, visualizations, and tools from the data sources to yield insights useful for service planning and operational improvement; 3. The design and implementation of a collaborative scenario planning process to allow community stakeholders to learn from and utilize the data collected to create proposals for transit service improvements. A hallmark of the project was an effort to boost community capacity, and it featured the extensive sharing of data, expertise, and tools. Supplemental funding allowed for the conversion of a research vehicle tracking system into an operational asset for the agency, and also resulted in the agency hiring a new permanent staff member. Scholarly outputs of the project include 18 peer-reviewed articles or paper presentations covering innovations in computer vision, travel surveying, transit system performance, travel demand modeling, and scenario planning
Additional file 10 of A facile and scalable in production non-viral gene engineered mesenchymal stem cells for effective suppression of temozolomide-resistant (TMZR) glioblastoma growth
Creators: name: Tu, Geraldine Xue En
name: Ho, Yoon Khei
name: Ng, Zhi Xu
name: Teo, Ke Jia
name: Yeo, Tseng Tsai
name: Heng-Phon Too
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: Additional file 10. Overlay of adipogenic differentiated AD-MSCs with GFP fluorescent image provides direct evidence of adipogenic differentiation of CD::UPRT::GFP expressing AD-MSCs. The images were captured at 20x magnification. Then, a representative set of images were cropped and enlarged.
The comparative data and phylogeny used in the analyses from The reduction in relative brain size in the domesticated dog is not an evolutionary singularity among the Canids
Creators: name: Garamszegi, László Zsolt
name: Kolm, Niclas
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310499
subject: Evolutionary biology not elsewhere classified

description: Canidae singularity_BiolLett_revised_supplement.docx
Additional file 11 of A facile and scalable in production non-viral gene engineered mesenchymal stem cells for effective suppression of temozolomide-resistant (TMZR) glioblastoma growth
Creators: name: Tu, Geraldine Xue En
name: Ho, Yoon Khei
name: Ng, Zhi Xu
name: Teo, Ke Jia
name: Yeo, Tseng Tsai
name: Heng-Phon Too
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: Additional file 11. Prolonged expression of CDy::UPRT::GFP. One day post-transfection (D0), cells were harvested and seeded in 24-well plate for further incubation. Cells were harvested for CD::URPT::GFP expression analysis after 1, 3, 5, 7 days (D1, D3, D5, D7) of incubation. For each time point, cells were fixed with 4% PFA for batch analysis. The % of GFP+ cells were determined by flow cytometry analysis. Graph presents mean + SD (n = 3). Significant differences between PEI + Enhancer and other protocols were calculated using two tailed Student’s t-test. **, P
Engagement in primary health care among marginalized people who use drugs in Ottawa, Canada
Creators: name: Kendall, Claire E
name: Boucher, Lisa M
name: Donelle, Jessy
name: Martin, Alana
name: Marshall, Zack
name: Boyd, Rob
name: Oickle, Pam
name: Diliso, Nicola
name: Pineau, Dave
name: Renaud, Brad
name: LeBlanc, Sean
name: Tyndall, Mark
name: Bayoumi, Ahmed M
Publisher: name: BioMed Central
Year: 2020

description: Background: There may be less primary health care engagement among people who use drugs (PWUD) than among the general population, even though the former have greater comorbidity and more frequent use of emergency department care. We investigated factors associated with primary care engagement among PWUD. Methods: The Participatory Research in Ottawa: Understanding Drugs (PROUD) cohort study meaningfully engaged and trained people with lived experience to recruit and survey marginalized PWUD between March–December 2013. We linked this survey data to provincial-level administrative databases held at ICES. We categorized engagement in primary care over the 2 years prior to survey completion as: not engaged (< 3 outpatient visits to the same family physician) versus engaged in care (3+ visits to the same family physician). We used multivariable logistic regression to determine factors associated with engagement in primary care. Results: Characteristics of 663 participants included a median age of 43 years, 76% men, and 67% living in the two lowest income quintile neighborhoods. Despite high comorbidity and a median of 4 (interquartile range 0–10) primary care visits in the year prior to survey completion, only 372 (56.1%) were engaged in primary care. Engagement was most strongly associated with the following factors: receiving provincial benefits, including disability payments (adjusted odds ratio [AOR] 4.14 (95% confidence interval [CI] 2.30 to 7.43)) or income assistance (AOR 3.69 (95% CI 2.00 to 6.81)), having ever taken methadone (AOR 3.82 (95% CI 2.28 to 6.41)), mental health comorbidity (AOR 3.43 (95% CI 2.19 to 5.38)), and having stable housing (AOR 2.09 (95% CI 1.29 to 3.38)). Conclusions: Despite high comorbidity, engagement in primary care among PWUD was low. Our findings suggest that social care (housing, disability, and income support) and mental health care are associated with improved primary care continuity; integration of these care systems with primary care and opioid substitution therapy may lessen the significant morbidity and acute care use among PWUD.
Load modelling for medium voltage SWER distribution networks
Creators: name: Hosseinzadeh, Nasser
name: Mastakov, Sergei
Publisher: name: Swinburne
Year: 2024

description: The supply of electricity to customers dispersed across wide geographical areas using the Single Wire Earth Return (SWER) distribution system has been adopted in many rural areas in Australia. This network system is the most economically practical method of supplying continuous power to scattered rural customers. With the increased demand for high power devices such as air conditioners and periodic events such as pumping, as well as the use of long and high impedance feeders, it becomes difficult to maintain good voltage regulation on these networks. Modelling of electrical networks is an important aspect of network analysis. However, current models for SWER networks do not reflect the conditions and voltage drops expected on the actual networks. The use of customer energy data and load diversity rules, in load allocation procedure, provides an opportunity to develop significantly more accurate models. The case studies of the Mistake Creek North and Stanage Bay SWER networks in Central Queensland show a significant improvement in the accuracy of the developed models reflecting the actual network performance.