title: Ð¦Ð¸ÑÐ¾Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ñ Ð°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²ÑÑ ÐºÐ»ÐµÑÐ¾Ðº Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð°ÑÑÐ¸ÑÐ½Ð¾Ð¹ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð¾Ð¹ Ð­ÑÐ»Ð¸Ñ Ð° Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÑÐ¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Cytomorphometric characteristics of tumor cells in mice with ascitic Ehrlich carcinoma treated with cytostatic drug
Creators: name: ÐÐ°ÑÐ»Ð¸ÐºÐ¾Ð²Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¼Ð¾Ð´ÐµÐ»Ñ Ð°ÑÑÐ¸ÑÐ½Ð¾Ð¹ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð­ÑÐ»Ð¸Ñ Ð°
ÐÐ°ÐºÐ»Ð¸ÑÐ°ÐºÑÐµÐ»
ÐÐ¸Ð¾ÐºÑÐ°Ð´ÑÑ
ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð°Ñ ÑÐ¸ÑÐ¾Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
Ð°Ð¼Ð¸ÑÐ¾Ð·
ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¹ Ð½ÐµÐºÑÐ¾Ð·
Ehrlich's ascitic carcinoma model
Paclitaxel
Dioxadet
computer cytomorphometry
mitosis
cell necrosis

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description: The purpose of this scientific work is a cytomorphometric study of the effect of the cytostatic domestic drug Dioxadet in the form of a new lyophilized drug form and the comparison drug Paclitaxel on ascitic fluid tumor cells on the Ehrlich ascitic carcinoma model in mice with intraperitoneal administration. Tasks that were solved during the study: Transplantation of a tumor strain to test animals; Cytological examination of ascitic fluid smears; Application of the method of computer cytomorphometry to study the reactive changes of tumor cells of ascitic fluid; Evaluation of the effect of Paclitaxel and Dioxadet on ascitic fluid cancer cells in mice with transplanted Ehrlich's tumor without treatment and with treatment with Paclitaxel and Dioxadet. Cytological analysis and computer cytomorphometry of ascitic fluid cancer cells in animals with an overgrown Ehrlich tumor were chosen as the main research methods. Paclitaxel at a dosage of 30 mg/kg does not affect the mitotic activity of tumor cells, but enhances the process of cell necrosis. Dioxadet at a dosage of 5 mg/kg inhibits cell division activity. The method of computer cytomorphometry can be recommended as an additional method for evaluating the antitumor activity of medicines and biologically active substances in experimental biomedical research.