Roles of microRNA-486-5p in the diagnosis and the association with clinical symptoms of cervical cancer
Creators: name: Wang, Lingling
name: Wang, Yan
name: Yang, Kang
name: Hu, Xiaowen
name: Ye, Guoliu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: <b>Aim:</b> To explore the predictive value of <i>miR-486-5p</i> in early cervical cancer and the associations of <i>miR-486-5p</i> with different clinical symptoms. <b>Materials &amp; methods:</b> A total of 185 women were recruited. The relative expression levels of serum <i>miR-486-5p</i> were analyzed by real-time polymerase chain reaction. The receiver operator characteristic curves were utilized to reflect the predictive performance of <i>miR-486-5p</i> and squamous cell carcinoma antigen for early cervical cancer. Univariate logistic regression and ranked logistic regression were used to explore the associations of <i>miR-486-5p</i> with different clinical symptoms of early cervical cancer, with odd ratios (ORs) and 95% confidence intervals. <b>Results:</b> Eighty-one women (44.26%) had early cervical cancer. The relative expression of serum <i>miR-486-5p</i> was 1.99-fold higher in early cervical cancer patients than that in controls (<i>p</i> &lt; 0.0001). The predictive performance of <i>miR-486-5p</i> for early cervical cancer was significantly superior to that of squamous cell carcinoma antigen, with an area under the curve of 0.865 (<i>p</i> &lt; 0.001), sensitivity of 1.000 and specificity of 0.804. In addition, overexpressed <i>miR-486-5p</i> was associated with high odds of maximum tumor diameter increase (OR = 1.30, 95% CI: [1.01–1.66]). <b>Conclusion:</b><i>MiR-486-5p</i> may be a potential biomarker for the early cervical cancer diagnosis, and was linked to the risk of maximum tumor diameter. Early-stage cervical cancers are asymptomatic and nonspecific, early detection is extremely hard. The potential target for <i>miR-486-5p</i> are linked to cervical cancer differentiation. This study contains real cases from a medical center in China. Relative expression of <i>miR-486-5p</i> between control and patients and the predictive performance of <i>miR-486-5p</i> on early-stage cervical cancer are assessed. Relative expression of serum <i>miR-486-5p</i> was significantly higher in early cervical cancer patients. The predictive value of <i>miR-486-5p</i> in early cervical cancer was superior to that of SCC-Ag. Overexpressed <i>miR-486-5p</i> was related to an increased risk of maximum tumor diameter increase. Serum <i>miR-486-5p</i> play an important role in early-stage cervical cancer and could be involved in multiple mechanisms. <i>MiR-486-5p</i> had the potential to be a competitive biomarker for early-stage cervical cancer due to it is a convenient, efficient and nonintrusive method. The link between <i>miR-486-5p</i> and maximum tumor diameter may help improve cervical cancer prognosis. <i>MiR-486-5p</i> could be a potential biomarker for early-stage cervical cancer. <i>MiR-486-5p</i> should be included in the strategies for screening and prognosis improvement in cervical cancer.