cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of Glucocorticoid-Induced TNF Receptor (GITR) Expression in Breast Cancer and Across Multiple Tumor Types
Creators: name: Zhu, Mayanne
name: Burugu, Samantha
name: Gao, Dongxia
name: Yu, Jamie
name: Kos, Zuzana
name: Leung, Samuel
name: Horst, Basil A.
name: Nielsen, Torsten
Publisher: name: Nature Publishing
Year: 2021

description: Glucocorticoid-induced TNF receptor (GITR) is an emerging immunotherapy target that is expressed at high levels on regulatory T cells. Agonistic anti-GITR antibodies have anti-tumor activity in cancer mouse models, and recent phase 1 trials have demonstrated their safe pharmacological profile. However, there is limited knowledge on the relationship between GITR expression and the tumor microenvironment. GITR protein expression was assayed by immunohistochemistry on 3992 breast cancer surgical excision specimens assembled into tissue microarrays and scored visually by a pathologist for GITR expression on tumor-infiltrating lymphocytes and on carcinoma cells. GITR expression by the malignant cells was further surveyed in gastrointestinal stromal tumor (N=713), lung carcinoma (N=705), pancreatic cancer (N=486), ovarian cancer (N=445), bladder cancer (N=88), prostate cancer (N=88), testicular cancer (N=76), melanoma (N=75), renal cell carcinoma (N=68), epithelial sarcoma (N=53), and neuroendocrine tumors (N=41). In breast cancer, GITR expression on tumor infiltrating lymphocytes (12.4%) correlated with other immune response biomarkers (PD-L1+ on tumor cells, and PD-1+, LAG3+, TIM-3+ lymphocytes; p < 0.001), and T cell markers (CD8+, FOXP3+; p < 0.001). GITR+ carcinoma cells were observed in 6.0% of breast cancer cases and correlated with worse relapse-free survival (p = 0.015). Among the additional tumor types examined, cancers with GITR+ malignant cells included bladder cancer (5.7%), primary (but not metastatic) melanoma (4.5%), and ovarian cancer (3.2%); no expression was identified among examined sarcomas. To our knowledge, this is the first immunohistochemistry study to report the frequency and pattern of GITR expression in a large breast cancer cohort, or to report membranous GITR expression on malignant cells. The co-infiltration of GITR with other immune biomarkers and T cell markers supports a potential role for anti-GITR agents in combination immunotherapies. In addition, GITR expression on carcinoma cells could imply the existence of a novel cancer immune evasion strategy worthy of further investigation.
The Treatment of Women Under Canada’s Gender Guidelines in Judicial Reviews of Gender-Related Refugee Claims: 2003-2013
Creators: name: See, Erica
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Refugee Law
Gender-related violence
Evidence
Canada

description: Abstract Women claiming refugee status in Canada must demonstrate to the Immigration and Refugee Board [IRB] that their claim is valid and plausible. Canada’s legislative framework acknowledges that gender-related persecution can qualify as a ground for refugee status under the United Nations Convention Relating to the Status of Refugees [Refugee Convention]. Specifically, the IRB’s Chairperson’s Guideline 4 – Women Refugee Claimants Fearing Gender-Related Persecution [Gender Guidelines] assist IRB decision-makers in deciding gender-related refugee claims by offering options for procedural accommodation and analytical guidance in the evaluation of gender-related claims. The Gender Guidelines aim to ensure decision-makers have “the degree of knowledge, understanding, and sensitivity” needed to make a “fair and correct judgment” of gender-related claims (Griffith v Canada (Minister of Citizenship and Immigration), [1999] FCJ No 1142 (QL)). The purpose of this research is to critically examine the use of the Gender Guidelines in IRB decisions on gender-related refugee claims and Federal Court judicial reviews of those claims. Looking at 166 Federal Court of Canada judicial reviews of gender-related claims of persecution previously rejected at the IRB level from 2003 to 2013, I used a grounded theory methodological basis and content analysis approach informed by Michel Foucault’s insights on power relationships and Judith Butler’s insights on performativity to examine discursive deployment of gender in refugee determinations through the treatment of the Gender Guidelines. I examined four legal standards used in these judicial reviews of gender-related claim determination—credibility assessments, plausibility assessments, availability of state protection, and the availability of an internal flight alternative [IFA]. I analyzed the application of these standards and looked at how variables such as country of origin or type of persecution or extrajudicial factors such as Canadian political discourse and rigid understandings of gender identity result in inconsistent application of the Gender Guidelines, thereby violating women refugee claimants’ right to procedural fairness. Several recommendations are made for changes at both the IRB and Federal Court level to correct identified barriers and to ensure all claims related to gender-related persecution have a full and fair opportunity to provide evidence and have it considered on its merits.
Beginner Teacher Perspectives on Pre-service Education and Transition Through Workplace Learning: A Comparative Study
Creators: name: Whitfield, Haley
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2008
Subjects: beginner teacher
transition
workplace learning
practicum
internship
identity
isolation
assessment
non-compulsory internship

description: The workplace learning of pre-service teachers remains one of the more significant aspects of initial teacher education courses, yet also one of the more contested. While the supervised teacher practicum remains the most common feature of this experience, a panoply of reports addressing teacher education in the last decade have outlined the need for major reform in the practicum. Such calls for reform occur in the context of increasing concern about the retention and attrition levels of beginner teachers. One alternative or partner to the practicum that has been increasingly employed is the teacher internship. Its value has been affirmed anecdotally by several groups such as employers, principals and early career teachers yet diverse views have been noted in the literature concerning the efficiency of the internship. This interpretivist study seeks to explore, in some depth, beginner teacher perspectives on pre-service education and transition through workplace learning. It takes advantage of the opportunity to study the contrasting experiences of two groups of graduates, now first year teachers, from one university in Queensland. One group completed the practicum only, while the other group opted to do a voluntary internship in addition to the mandatory practicum. This study also identifies the perspectives of the two different cohorts on how their experiences have prepared them for the transition into teaching, particularly with a view to providing new insights into the importance or otherwise of internships in the process of becoming a teacher. Semi-structured interviews were used to collect teachers' perspectives, with the ultimate intention of arriving at a naturalized generalization of experience in individual events, through intensive analysis of each case, recognizing its complexity and context. This pilot study may offer deep insights into the perspectives of this cohort and may provide a research platform for a more comprehensive study in the future.
“Qualche Ornamento Stabile, Perpetuo” Die Silberstatue des Hl. Franz Xaver in Goa und ihre performative Vereinnahmung im 17. Jahrhundert
Creators: name: Krass, Urte
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55, Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
UBA-Frau Marina Köhn: "Am Ende soll eine Energiekennzeichnung für Rechenzentren stehen."
Creators: name: Rüdiger, Ariane
Publisher: name: My University
Year: 2022

description: Inzwischen gibt es 'Blaue Engel' für Datacenter-Dienstleistungen und Energie-effizienten Rechenzentrumsbetrieb. Doch der Markt nimmt diese Zertifizierungen nur zögerlich an. Autorin Ariane Rüdiger sprach für DataCenter-Insider mit Marina Köhn, (Wissenschaftliche Mitarbeiterin) beim Umweltbundesamt (UBA) über die Gründe und die diesbezüglichen Pläne des UBA. Quelle: https://www.datacenter-insider.de/
Modell, Modul, Metapher die italienische Piazza als Nach-Bild der Stadt
Creators: name: Sölch, Brigitte
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55, Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
'Hitler's Carpet' A Tale of One City
Creators: name: Caraffa, Costanza
name: Shalem, Avinoam
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55, Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Gebündelte Infrastrukturplanungen und -zulassungen und integrierter Umbau von regionalen Versorgungssystemen (INTEGRIS)
title: Gebündelte Infrastrukturplanungen und -zulassungen und integrierter Umbau von regionalen Versorgungssystemen
titleType: AlternativeTitle
Creators: name: Niederste-Hollenberg, Jutta
name: Marscheider-Weidemann, Frank
name: Peters, Wolfgang
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: Infrastruktur
Umweltverträglichkeitsprüfung
Nachhaltigkeits-Check
Infrastrukturplanung
Zulassungsverfahren
Regionalplanung

description: Durch die gemeinsame Verlegung und Bündelung von verschiedenen Infrastrukturen für Strom, Wasser, Gas, Informations- und Kommunikationsdienste, Fernwärme, Abwasser u. a. in einer Trasse werden geringere Umweltbelastungen sowie soziale und ökonomische Vorteile erwartet. Bündelungsgebote bzw. Bündelungsmöglichkeiten sind zum Teil rechtlich verankert, etwa im Naturschutzrecht oder im Raumordnungsrecht. Die Studie hat die Klärung von Verfahrensfragen zur Planung und Zulassung und die Bewertung der Nachhaltigkeit im Rahmen der Regionalentwicklung mit Blick auf zukünftige Anforderungen an Infrastrukturen zum Ziel. Die im Projekt durchgeführte Nachhaltigkeitsbewertung am Beispiel des Bauvorhabens der Kommunalen Netze Eifel (KNE) hat gezeigt, dass prinzipiell eine gebündelte Verlegung von Infrastrukturen einer Einzelverlegung vorzuziehen ist. Aus den Vergleichsergebnissen der Umweltwirkungen gebündelter und einzeln verlegter Infrastrukturen sowie aus der rechtlichen Einordnung leiten sich abschließend Empfehlungen für die Planungspraxis ab. Eine Betrachtung von möglichen Zukunftsszenarien macht die Notwendigkeit einer gestaltenden Politik deutlich. Die einzelnen Sektoren sind zukünftig enger miteinander verzahnt; Knotenpunkte als Punkte der Umwandlung verschiedener Energieträger werden wichtiger. Eine Strategie, die eine sektorenübergreifende Planung beinhaltet und bspw. mindestens Knotenpunkte vorsieht, an denen sich verschiedenen Infrastrukturen "treffen", ist daher sinnvoll und notwendig. Quelle: www.umweltbundesamt.de
Processus et intensité actuelle et holocène de l'érosion du marbre de Grenville, région de Gatineau-Lièvre, Québec.
Creators: name: Prévost, Clément L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Physical Geography.

description: Limestone tablets placed in various aquatic environments yielded a mean rate of erosion of 22,8 mm/1000 years. Within different soil media, the same method gave a 12,4 mm/1000 years intensity of erosion. The hydrochemical approach gave a mean rate of 21,4 mm/1000 years, but the median rate of 17,2 mm/1000 years is believed to be closer to reality. The karsts developed on the crystalline (metamorphic) limestone of the study area are found at the surface as well as underground. Fossil caves hang on the valley slopes far from the actual streams. Many active caves show in their path fossil phreatic tubes superimposed on active vadose corridors. Rates of erosion topographic position, and the sediment filling of the fossil caves, suggest that these could be pre-Holocene in age. One model implies a sub-glacial dissolution by meltwater (phreatic tube) and a subsequent Holocene erosion (vadose corridor). The second model implies a washing-away of sediments by glacial meltwater within a pre-holocene cave, followed by Holocene erosion. (Abstract shortened by UMI.)
Methodologies in workplace research: relevant paradigms for reform from the inside
Creators: name: Melles, Gavin
Publisher: name: Swinburne
Year: 2024

description: Conducting applied research in workplace settings on/with colleagues brings with it a whole host of ethical and procedural issues about research. Empiricist, interpretive, and critical approaches all have a place in understanding, describing and changing curriculum perceptions and as one moves from one paradigm to the other the voices of the agents in the curriculum process become increasingly prominent. With reference to some of my own workplace research under the three paradigms above, I describe ways in which educational research in workplace settings represents curriculum reality and can act as an engine of change.
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55 Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: Band LV (2013), Heft 1
description: Inhalt
'Hitler's Carpet' A Tale of One City...118-143
Modell, Modul, Metapher die italienische Piazza als Nach-Bild der Stadt...94-117
“Qualche ornamento stabile, e perpetuo” Die Silberstatue des Hl. Franz Xaver in Goa und ihre performative Vereinnahmung im 17. Jahrhundert...72-93
‘Vasart’ Versus Vasari la Duplice Attualità delle "Vite"...54-71
Les Marbres de Giotto Astrologie et Naturalisme à la Chapelle Scrovegni...8-25
Two “Official” Languages of Work: Explaining the Persistence of Inequitable Access to French as a Language of Work in the Canadian Federal Public Service
Creators: name: Gaspard, Helaina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Official Languages
Institutionalism
Canadian federal public service
Bilingualism
Language of work
Language rights
Language policy
Policy implementation
Institutional change

description: Canada’s official languages policy makes English and French the country’s official languages in federal institutions. The policy has succeeded in fostering equitable representation of both official languages groups in the federal public service and has improved capacities for the public service to serve the citizenry in its official language of choice. It is a puzzle however, that despite these advances, the Canadian federal public service continues to operate predominantly in English when both official languages on paper are equal languages of work. To explore this puzzle this dissertation asks: why, despite the promise of the Official Languages Act (OLA) 1969 for choice in language of work and the OLA 1988 that made the choice a claimable right, is there inequitable access to French as a language of work in the federal public service? Framed through a historical institutionalist approach and layering, this project analyzes the implementation of the official languages program in the federal public service from 1967-2013. This thesis argues that the implementation of the official languages program could not challenge the federal public service’s path dependency to operate predominantly in English. By analyzing the roles of actors and institutions that influenced the process, this dissertation finds that lack of structural change, inadequate managerial engagement and a false sense that official languages are engrained in the public service, can explain the persistence of English as the dominant language of work.
Supplementary document for Distinguishing between coherent and incoherent signals in excitation-emission spectroscopy - 5293023.pdf
Creators: name: De Sio, Antonietta
name: Lünemann, Daniel C.
name: Thomas, Anitta
name: Xu, Jingjing
name: Bartölke, Rabea
name: Mouritsen, Henrik
name: Lienau, Christoph
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised Supplemental, S1-S6
SNF2H-Mediated Chromatin Remodelling and Its Regulation of the Pluripotent State
Creators: name: Cook, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: subject: Chromatin
subject: Remodelling
subject: Pluripotency
subject: Epigenetics
subject: Sequencing
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: In embryonic stem cells (ESCs), the SWI/SNF, CHD, and INO80 families of ATP-dependent chromatin remodellers have been implicated in maintaining pluripotency-associated gene expression, however the involvement of ISWI family remodellers has yet to be defined. Here, we explore the importance of the mammalian ISWI homologue SNF2H (Smarca5) by deriving a conditional knockout mouse ESC line and observing the consequences of SNF2H depletion on the pluripotent state. Cre-mediated deletion of Snf2h disrupts hallmark characteristics of pluripotency, resulting in distinct morphological changes; reduced expression of the master transcription factors Oct4, Sox2, and Nanog; and reduced alkaline phosphatase activity. To understand the mechanisms of SNF2H-mediated regulation, we mapped SNF2H-bound nucleosomes genome-wide. SNF2H is broadly distributed across the genome, but is preferentially enriched at active regulatory regions and transcription factor binding sites. These findings demonstrate the importance of SNF2H in ESCs and shed light on genome-wide mechanisms of transcriptional regulation.
Les Marbres de Giotto Astrologie et Naturalisme à la Chapelle Scrovegni
Creators: name: Cordez, Philippe
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55, Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
‘Vasart’ Versus Vasari la Duplice Attualità delle "Vite"
Creators: name: Nova, Alessandro
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 55, Nr. 1 (2013): Mitteilungen des Kunsthistorischen Institutes in Florenz
The Role of Signaling Pathway Integration in Neurogenesis
Creators: name: Ringuette, Randy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Neurogenesis
Retina
Hedgehog
Notch
Receptor Tyrosine Kinase
Pathway Integration
Progenitor Cell
Gli

description: Proper central nervous system development is critical for survival and depends on complex intracellular and extracellular signaling to regulate neural progenitor cell growth and differentiation; however, the mechanisms that mediate molecular crosstalk between pathways during neurogenesis are not fully understood. Here, we explored the integration of the Hedgehog (Hh) signaling pathway with the two critical developmental pathways, Receptor Tyrosine Kinase (RTK) and Notch signaling, in the growth and maintenance of neural progenitors in the developing neuroretina. We found combined and sustained RTK and Hh signaling was sufficient to establish long-term retinal progenitor cell (RPC) cultures and these cells maintained neurogenic and gliogenic, but not retinogenic, competence in vitro and in vivo. In addition, we identified crosstalk between Notch and Hh signaling, where Notch is required for Hh-mediated proliferation and Gli protein accumulation, and gain-of-function of Notch is sufficient to extend the window of Hh responsiveness in a subset of Müller glia. Both Hh-RPC monolayer establishment and Notch mediated Hh-responsiveness required Gli2. Taken together, we identified molecular cross-communication between the Hh pathway and two major pathways, Notch and RTK, during retinogenesis, advancing our understanding of mechanisms that influence Hh to control neural progenitor growth.
Le mal du pays: nostalgie et retour aux sources dans les contes de Fred Pellerin
Creators: name: Roussel, Stéphanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016

description: Cette thèse de maîtrise est une analyse du concept du retour dans les trois premiers recueils de contes publiés par Fred Pellerin : Dans mon village, il y a belle Lurette… (2001), Il faut prendre le taureau par les contes! (2003) et Comme une odeur de muscles (2005). L’objectif est de démontrer que la nostalgie pour le passé et le désir du retour aux sources représentent un concept qui revient à plusieurs reprises dans les contes de Pellerin et qu’il suscite un engouement chez ses lecteurs. En ce qui a trait à la méthodologie, cette thèse se divise en deux grandes parties intitulées respectivement « Les grands thèmes » et « Langue et procédés techniques ». La première partie porte sur l’analyse des différents motifs qui font partie intégrante de l’ensemble de l’oeuvre de Fred Pellerin: les thèmes du refuge, de la solidarité, du village, de l’histoire et du passé seront, entre autres, analysés. La deuxième partie étudie les particularités de la langue de l’auteur. L’histoire de la langue française au Québec, les niveaux de langage et les procédés techniques sont les principaux éléments qui caractériseront cette partie du travail.
Una Tavola Francescana per le Terziarie dello Spedale di San Paolo a Firenze
Creators: name: Sgarrella, Anna
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 3 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
Smart filters for the analysis of microplastic in beverages filled in plastic bottles
Creators: name: Braun, Ulrike
name: Altmann, Korinna
name: Herper, Dominik
Publisher: name: My University
Year: 2021
Subjects: Filter
Flasche
Getränkeverpackung
Kunststoff
Kunststoffflasche
Mikroplastikpartikel
Partikelabscheider
Probenahmetechnik

description: The occurrence of microplastic (MP) in food products, such as beverages in plastic bottles, is of high public concern. Existing analytical methods focus on the determination of particle numbers, requiring elaborate sampling tools, laboratory infrastructure and generally time-consuming imaging detection methods. A comprehensive routine analysis of MP in food products is still not possible. In the present work, we present the development of a smart filter crucible as sampling and detection tool. After filtration and drying of the filtered-off solids, a direct determination of the MP mass content from the crucible sample can be done by thermal extraction desorption gas chromatography mass spectroscopy (TED-GC/MS). The new filter crucible allows a filtration of MP down to particle sizes of 5 (micro)m. We determined MP contents below 0.01 (micro)g/L up to 2 (micro)g/L, depending on beverages bottle type. This may be directly related to the bottle type, especially the quality of the plastic material of the screw cap. Dependent on the plastic material, particle formation increases due to opening and closing operations during the use phase. However, we have also found that some individual determinations of samples were subjected to high errors due to random events. A conclusive quantitative evaluation of the products is therefore not possible at present. © Taylor&Francis Online
"Venere nella Fucina di Vulcano" Di Felice Brusasorci: Un Nuovo Tassello per la Galleria di Cornelis Van Der Geest
Creators: name: Dossi, Davide
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 3 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
Mechanisms involved in the disruption and restoration of excitation-contraction coupling in the rat myocardium by hypochlorous acid and dithiothreitol.
Creators: name: Eley, Douglas W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Animal Physiology.

description: In the present studies, the addition of HOCl to the bathing medium for isometrically contracting papillary rat papillary muscles induced the development of contracture. This was characterized by a decline in developed tension (DT) in combination with a rise in resting tension (RT), a prolongation in relaxation kinetics, and a sensitivity of the muscles to stimulation voltage. This response to HOCl was potentiated by preincubation with low extracellular Ca$\sp{2+}$ or the Ca$\sp{2+}$ channel antagonist nifedipine. Conversely, the response was attenuated by preincubation with high extracellular Ca$\sp{2+}$ concentrations or with the Ca$\sp{2+}$ channel agonist Bay K 8644. The development of contracture was prevented by preincubation with 1 nM ryanodine, an alkaloid compound known to alter Ca$\sp{2+}$ handling by the sarcoplasmic reticulum. In isolated whole-cell clamped cardiac myocytes, using the Ca$\sp{2+}$ fluorescence indicator Fura-2 to monitor (Ca$\sp{2+}$) $\sb{\rm i}$, HOCl induced a steady rise in diastolic (Ca$\sp{2+}$) $\sb{\rm i}$ even in the absence of extracellular Ca$\sp{2+}$. This rise in (Ca$\sp{2+}$) $\sb{\rm i}$ was prevented by pre-exposure of the cell to 5 mM caffeine, a compound known to deplete the SR of stored Ca$\sp{2+}$. In oxalate loaded SR vesicles isolated from rat hearts perfused with HOCl, both the activity of the SR Ca$\sp{2+}$-ATPase (determined by inorganic phosphate production) and the uptake of $\sp{45}$Ca$\sp{2+}$ were significantly depressed as compared to Control. I conclude that the exposure of the rat myocardium to HOCl inactivates the SR Ca$\sp{2+}$-ATPase through the oxidation of protein thiols, leading to a cytosolic Ca$\sp{2+}$ overload and the development of contracture. Cursery evidence also suggests that the Ca$\sp{2+}$ pump of the sarcolemma and the Na$\sp+$/Ca$\sp{2+}$ exchanger may also be inactivated. Subsequent exposure of the HOCl-treated myocardium to the disulfide reducing agent dithiothreitol (DTT) resulted in a restoration of contractile function, characterized by a decline in RT concomitant with a recovery of DT in the isolated papillary model, or a recovery of left ventricular end diastolic pressure and developed pressure in the perfused rat heart. We conclude that DTT was able to cross cellular membranes where it restored cellular protein thiol levels by reducing HOCl-induced disulfide formation. (Abstract shortened by UMI.)
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54 Nr. 3 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: Band LIV (2010-2012), Heft 3
description: Inhalt
Titelei
"Venere nella Fucina di Vulcano" Di Felice Brusasorci: Un Nuovo Tassello per la Galleria di Cornelis Van Der Geest...541-550
Una Tavola Francescana per le Terziarie dello Spedale di San Paolo a Firenze...521-529
Heiligenlob in Text und Bild. Der Hl. Dominikus und Ghirlandaios Pala für Santa Maria Novella...425-444
Heiligenlob in Text und Bild. Der Hl. Dominikus und Ghirlandaios Pala für Santa Maria Novella
Creators: name: Leuker, Tobias
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 3 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
I Giorni dell'Alluvione al Kunsthistorisches Institut dalla Corrispondenza di Alexander Kreuter e Hans Martin Von Erffa
Creators: name: Giannini, Cristina
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54 Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: Band LIV (2010-2012), Heft 1
description: Inhalt
I Giorni dell'Alluvione al Kunsthistorisches Institut dalla Corrispondenza di Alexander Kreuter e Hans Martin Von Erffa...196-206
Il Contributo di Pirro Ligorio e di Piero Vettori al "De Arte Gymnastica" di Girolamo Mercuriale: Il Disegno del Braccio con Disco...185-195
Spigolature Vasariane. Per un Riesame delle "Vite" e della Loro Fortuna nella Roma di Primo Seicento...155-184
"Questa Opera Addunque Tolse a lui la Morte". Baccio Bandinelli e il Primo Progetto di una Fontana per Piazza della Signoria...59-114
Old and New. Divine Revelation in the Salerno Ivories...1-30
Old and New. Divine Revelation in the Salerno Ivories
Creators: name: Müller, Kathrin
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
"Questa Opera Addunque Tolse a lui la Morte". Baccio Bandinelli e il Primo Progetto di una Fontana per Piazza della Signoria
Creators: name: Vossilla, Francesco
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
Le fonctionnement en communauté d’apprentissage professionnelle dans six écoles de langue française au Canada : conditions d’implantation
Creators: name: Maatouk, Ziad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Communauté d’apprentissage professionnelle
CAP
Conditions d'implantation

description: La présente recherche vise à comprendre l’implantation qui a été mise en oeuvre dans six écoles, élémentaires et secondaires, du Nouveau-Brunswick, de l’Ontario et du Québec, pour atteindre un stade avancé dans le fonctionnement en communauté d’apprentissage professionnelle (CAP). Notre recherche s’inscrit dans le cadre du projet de recherche pancanadien d’IsaBelle, Davidson, Fournier, Rochon et Chiptin (2010). Le choix des écoles participant à cette étude émane des trois critères suivants : a) avoir atteint un stade avancé (stade 2 ou 3) dans le fonctionnement en CAP selon la grille des comportements associés aux stades d’évolution des CAP d’IsaBelle, Rochon, Génier et Lamothe, (2012), b) observer une certaine augmentation dans les résultats des élèves durant les deux ou trois dernières années selon les données de l’école ou selon la perception des directions et c) la direction devait être en poste dans la même école depuis au moins trois ans et les enseignants devaient avoir une expérience d’au moins trois ans dans le fonctionnement en CAP. Notre recherche s’inscrit dans le courant qualitatif interprétatif; elle cherche à comprendre le sens de l’expérience vécue par des acteurs (directions et enseignants) dans une structure axée sur un fonctionnement en CAP. Cette recherche tente de décrire, à partir du vécu des directions d’école et des enseignants, les conditions favorables à l’implantation et à la progression du fonctionnement en CAP dans les écoles élémentaires et secondaires ayant un fonctionnement avancé. Dans les six écoles, des entrevues semi-dirigées ont été menées auprès de la direction et de deux enseignants d’école élémentaire et l’école secondaire. Les questions posées dans les entrevues ont été élaborées à partir des conditions d’implantation mentionnées dans les écrits et à partir du modèle de la dynamique d’interaction développé par Corriveau, Boyer et Fernandez (2009) qui s’appuie sur la théorie de la structuration d’Anthony Giddens (1987). De là, trois grands thèmes ont été abordés dans la grille d’entrevue : la structure organisationnelle, la structure relationnelle et la structure identitaire.
'Don't send me your saliva': fantasies of disembodiment in email and epistolary technologies
Creators: name: Milne, Esther
Publisher: name: Swinburne
Year: 2024

description: This paper is part of a larger investigation about the relation between electronic mail and the epistolary tradition. The overall project looks at the history of the paper-based postal service in order to identify points of contrast and comparison with the system of electronic mail. It argues that the points of congruity between a letter and electronic mail remain under-theorised by those interested in epistolary practice and those that research computer mediated communication. In this paper I explore and critique one of the key terms — the notion of disembodiment — that functions in both systems of communication. “Disembpdiment” refers to the perceived absence of the corporeal body in the communicative act. But the term also speaks to the desire for the circulation of “pure” information unfettered by the materiality of the system on which it depends and free from the exigencies that past technologies exert upon the present.
The Paradox of Bultmann’s Historical Jesus for Faith: A Question of History
Creators: name: Booth, Bernard
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Rudolf Bultmann

description: Rudolf Bultmann created an individualist theology of existentialism to replace the ethical-moral theology of the liberal tradition. The impact of Bultmann’s theology, which privileged post-Easter church kerygma over the historical Jesus, is the core of the problem and is situated in Bultmann’s existentialist view of history, derived from Martin Heidegger’s Being and Time. His theology derived additional, important support from the findings of Hans Jonas’ dissertation on Gnosticism. Bultmann divided history into two components, positivist history (Historie), and individualised history (Geschichte). The study examines strengths and weaknesses in Bultmann’s historical epistemology, with respect to conflict between the historical Jesus and the post-Easter kerygmatic faith of the disciples, the social and cultural spin-offs of alienation and anti-Judaism, and the resulting conflict with former students and foreign scholars. The conclusion is that Bultmann was so opposed to liberal historiography that he was willing to construct a theology of individual existence, devoid of social responsibility to the world at large, and replete with inconsistency regarding continuity between the historical Jesus and the kerygma. Nevertheless, Bultmann is credited with awakening the need to examine the authenticity of the gospels and New Testament message in a new light.
Sewage sludge management in Germany
Creators: name: Brandt, Simone
name: Wiechmann, Benjamin
name: Dienemann, Claudia
name: Kabbe, Christian
name: Roskosch, Andrea
name: Vogel, Ines
Publisher: name: My University
Year: 2015
Subjects: subject: Klärschlammbeseitigung
subject: Abfallablagerungsverordnung
subject: Regionalstatistik
subject: Klärschlammbehandlung
subject: Klärschlamm
subject: waste
subject: sewage sludge
subject: Abfall | Ressourcen
subject: Waste | Resources

description: Germany’s municipal sewage treatment plants generate some two million tons of dry sewage sludge annually, with the proportion of thermallytreated sewage sludge increasing from 31.5 per cent in 2004 to more than 54 % in 2011.
Plasmonic Metasurfaces
Creators: name: Tahir, Asad Ahmad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Nanophotonics
Plasmonics
Nonlinear optics
ENZ materials science

description: Nanophotonics is a booming field of research with the promise of chip-scale devices which harness the tremendous potency of light. In this regard, surface plasmons have shown great potential for confining and manipulating light at extreme sub-wavelength scales. Advances in fabrication technology have enabled the scientific community to realize metasurfaces with unconventional properties that push the limits of possible applications of light. This thesis is comprised of computational and experimental studies on plasmonic metasurfaces. The computational study presents efficient design principles for plasmonic half-wave plates using L-shaped nanoantennas. These principles can be used to design waveplates at an operating wavelength of choice and for specific application requirements. The impact of this study goes beyond the efficient design of waveplates: it provides useful insights into the Physics of L-shaped nanoantenna arrays which have been proposed as building blocks for plasmonic metasurfaces. The experimental work investigates the interaction of a plasmonic metasurface, composed of dipole antenna arrays, with an epsilon-near-zero (ENZ) material. This work thus forms a bridge between plasmonics and ENZ materials science, which is a rapidly advancing field in its own right. The first experimental study investigates the exciting unconventional response of plasmonic dipole antennas when placed on a thin indium tin oxide (ITO) film near its ENZ wavelength of 1417 nm. The antenna-on-ITO system has split resonances whose spectral positions are largely independent of the antenna dimensions. The resonance splitting occurs due to coupling between the antenna resonance and the ENZ mode of the ITO film. This coupling results in field intensity enhancements on the order of a 100 in the ITO film. The second experimental study demonstrates, using the z-scan method, that this large field enhancement in the antenna-on-ITO structure further enhances the already strong nonlinearity of ITO around its ENZ wavelength. In particular, the antenna-on-ITO structure exhibits an extremely large nonlinear absorption coefficient, which is two orders of magnitude larger than that of a bare ITO film, and three to five orders of magnitude larger than that of many other nonlinear materials. This thesis thus constitutes a beautiful blend of three thriving areas of research: plasmonics, ENZ materials science and nonlinear optics. The findings reported here have the potential to contribute to all of these fields, and thus have relevance to a broad spectrum of optical scientists.
Additional file 1 of Tissue Doppler Imaging and strain rate of the left atrial lateral wall: age related variations and comparison with parameters of diastolic function
Creators: name: Argento, Laura V.
name: Travetto, Carolina M.
name: Colicigno, Maria De Las M.
name: Marambio, Gerardo
name: Gentile, Silvia
name: Salvati, Ana
name: Lax, Jorge
name: Cianciulli, Tomás
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1: Supplemental Table 1. Analysis of the variables by age subgroups.
Providing guidelines for first year assessment tasks: nurturing or spoonfeeding?
Creators: name: Levin, Elizabeth
name: Tempone, Irene
Publisher: name: Swinburne
Year: 2024

description: Developing written and oral communication skills are an important part of the frrst year university experience. Subject convenors have clear expectations of their students but do they clearly communicate these requirements? During the frrst year of a course it is important to set the tone and standards for later studies. Despite the fact that different disciplines may have differing writing and oral presentation requirements, with a little thought and effort students can be given guidelines, which will provide them with a blueprint for future success. Tlris can be achieved and reinforced in a variety of ways without overloading the student at any one time. This paper will describe the rationale for providing thorough instr11ctions for assigrunents and case studies to frrst year students emolled in a core business subject with the objective of guiding students into deep approaches to learning wlrich lead to qualitatively better learning outcomes, and to developing core generic skills. Finally some recommendations as to how clear requirements can be developed and communicated are provided.
Spigolature Vasariane. Per un Riesame delle "Vite" e della Loro Fortuna nella Roma di Primo Seicento
Creators: name: Carrara, Eliana
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
Les pays scandinaves et l’identité européenne
Creators: name: Guitard-Lortie, Guillaume
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Suède
Danemark
Norvège
identité européenne
identité nationale

description: Résumé Le Danemark, la Norvège et la Suède sont négligés dans l’étude de l’identité européenne et de la multiplicité identitaire. Cette région est marquée par une complexité identitaire en raison de la présence d’identités locale, régionale, nationale et de deux identités supranationales, la Scandinave et l’Européenne. Cette complexité soulève certaines questions. Les identités nationale et supranationale sont-elles compatibles et complémentaires? Quelle est l’intensité de ces identités? Quelle est la relation entre les identités scandinave et européenne? Pour répondre à ces questions, nous effectuons une recension de la littérature qui est complétée d’une analyse de divers sondages. Aussi, deux typologies tirées de la littérature sont utilisées pour répondre aux questions. En comparant les données obtenues pour chaque pays, nous observons que les écrits tendent à opposer et à polariser les identités en Scandinavie, alors que les données statistiques de sondages les nuancent et montrent qu’elles sont compatibles. Les pays scandinaves ont une identité nationale forte, mais aussi une identité européenne en développement. Abstract Denmark, Norway and Sweden have been neglected in the study of European identity and multiple identities. With the presence of local, regional, national and two supranational identities, the Scandinavian and European identities, this region is characterized by a complex set of identities that need to be studied. A number of questions come up regarding this situation. Are national and supranational identities compatible and complementary? What is the intensity or strength of these identities? What is the relationship between the Scandinavian and European identities? To answer these questions, we proceed by doing a review of the literature, followed by a survey analysis. We also use two typologies drawn from works on identity to answer these questions. By comparing data for each country, we were able to observe that the literature tends to oppose identities and view them as mutually exclusive, whereas surveys moderate these conclusions and show that national and supranational identities are complementary. National identities are strong in Scandinavia, but European identity progressing.
Il Contributo di Pirro Ligorio e di Piero Vettori al "De Arte Gymnastica" di Girolamo Mercuriale: Il Disegno del Braccio con Disco
Creators: name: Vagenheim, Ginette
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 1 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz
Functional Analysis of a Coding Variant In ZC3HC1 at 7q32.2 Associated with Protection Against Coronary Artery Disease (CAD)
Creators: name: Linseman, Tara
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: subject: Cell Cycle
subject: CAD
subject: Genetics
subject: FOS: Biological sciences
subject: Protein

description: Coronary artery disease (CAD), characterized by the narrowing of coronary arteries through the complex manifestation and development of atherosclerosis, is a complex disease and one of the leading causes of death worldwide. Both genetic and environmental factors are believed to contribute equally to the risk of CAD. Recently, a study identified a non-synonymous coding variant, rs11556924, (MAF, 0.38) in ZC3HC1 associated with protection against CAD (p= 9.8x10-18; OR= 0.90). NIPA, encoded by ZC3HC1, is a characterized F-Box protein and regulator of cell cycle. Since the amino acid change (Arg363His) is in a conserved region of NIPA and is predicted to have functional effects (Polyphen-2), this study aimed at understanding the functional implications of this amino acid change on NIPA and cell cycle regulation. Here we are able to effectively show a) allele specific differences in mRNA expression in whole blood, b) a slight structural difference between NIPA363Arg and NIPA363His variants, c) proliferation rates of NIPA363Arg expressing cells were significantly increased, and d) phosphorylation of a critical serine residue in close proximity to aa.363 is not statistically different between the two variants. These results suggest that rs11556924 plays a direct role in development of CAD through its disruption of cell cycle regulation and NIPA mRNA availability. This study is the first to identify a molecular basis for the association of rs11556924 to CAD development.
Supplementary document for MuellerNet: A hybrid 3D-2D CNN for cell classification with Mueller matrix images - 5295690.pdf
Creators: name: Ma, Dongdong
name: Lu, Zongqing
name: xia, longyu
name: Liao, Qingmin
name: Yang, Wenming
name: Ma, Hui
name: Liao, Ran
name: MA, L
name: Liu, Zhidi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Extra visualizations and tables in experiments.
Additional file 1 of The reliability and validity of the Arabic version of the Mouth Handicap in Systemic Sclerosis (MHISS) Questionnaire in Arabian systemic sclerosis patients
Creators: name: Enas A. Elattar
name: Balata, Mona G.
name: Mallah, Reem El
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
New Light on Pietro, Antonio, and Tullio Lombardo
Creators: name: Schulz, Anne Markham
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2018

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 54, Nr. 2 (2010): Mitteilungen des Kunsthistorischen Institutes in Florenz