cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Does self-efficacy affect cognitive performance in persons with Clinically Isolated Syndrome and early Relapsing Remitting multiple sclerosis?
Creators: name: Jongen, Peter Joseph
name: Wesnes, Keith
name: Van Geel, Bjorn
name: Pop, Paul
name: Schrijver, Hans
name: Visser, Leo H.
name: Gilhuis, H. Jacobus
name: Sinnige, Ludovicus G.
name: Brands, Augustina M.
Publisher: name: Swinburne
Year: 2024

description: In persons with multiple sclerosis (MS) a lowered self-efficacy negatively affects physical activities. Against this background we studied the relationship between self-efficacy and cognitive performance in the early stages of MS. Thirty-three patients with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting MS (eRRMS) were assessed for self-efficacy (MSSES-18), cognition (CDR System), fatigue (MFIS-5), depressive symptoms (BDI), disease impact (MSIS-29), and disability (EDSS). Correlative analyses were performed between self-efficacy and cognitive scores, and stepwise regression analyses identified predictors of cognition and self-efficacy. Good correlations existed between total self-efficacy and Power of Attention (r = 0.65; P < 0.001), Reaction Time Variability (r = 0.57; P < 0.001), and Speed of Memory (r = 0.53; P < 0.01), and between control self-efficacy and Reaction Time Variability (r = 0.55; P < 0.01). Total self-efficacy predicted 40% of Power of Attention, 34% of Reaction Time Variability, and 40% of Speed of Memory variabilities. Disease impact predicted 65% of total self-efficacy and 58% of control self-efficacy variabilities. The findings may suggest that in persons with CIS and eRRMS self-efficacy may positively affect cognitive performance and that prevention of disease activity may preserve self-efficacy.
Autodeterminazione e motivazione intrinseca in differenti ambiti motori
Creators: name: Soler, Andrea Mario
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2024
Subjects: motivazione intrinseca
autodeterminazione
autoefficacia
autonomia
educazione fisica
ambiti motori

description: L’educazione fisica riveste un ruolo cruciale nel contesto della scuola media, agendo come catalizzatore per il benessere fisico, psicologico e sociale degli studenti. La sfida dei docenti è quella di proporre attività diversificate, ma che possano essere egualmente stimolanti e sufficientemente dispendiose dal punto di vista energetico. La teoria dell’autodeterminazione può aiutare in questo senso: risulta quindi importante conoscere come e se cambiano la motivazione intrinseca e lo sforzo in attività appartenenti a differenti ambiti motori. I risultati hanno mostrato che, in lezioni costruite secondo la teoria dell’autodeterminazione, non esiste significativa differenza nei parametri citati. Questo implica che strutturando una lezione favorendo autonomia, autoefficacia e libertà di scelta, si può agire in maniera significativa sulla motivazione intrinseca indipendentemente dall’ambito motorio di riferimento. Rimane cruciale conoscere questo tema per stimolare gli allievi anche nelle attività motorie apparentemente per loro più demotivanti e meno interessanti. Relatrice: Barbara Hauser.
A portfolio of research work including an interpretative phenomenological analysis of MDMA assisted psychotherapy for PTSD.
Creators: name: Ruger, Michelle
Publisher: name: University of Surrey
Year: 2020

description: This portfolio comprises a culmination of research work spanning three years of full- time training on the Practitioner Doctorate course in Psychotherapeutic and Counselling Psychology (PsychD) at the University of Surrey. The research comprises three research reports: a literature review, and two qualitative studies. The literature review explores the psychedelic renaissance, focusing on the resurgence of studies into utility of psychedelic drugs as an adjunct to psychotherapy. The first empirical study is a Thematic Analysis of therapists who have worked with clients when they were under the influence of a psychedelic during a research trial. The study seeks to explore how they experienced the interplay between the drugs and psychotherapeutic practice. The analysis revealed three master themes: i) ‘The Facilitation of Process ii) ‘The Therapeutic Relationship’ iii) ‘The Power of a Transcendental Experience. The second empirical study used Interpretative Phenomenological Analysis (IPA) analysis to explore the lived experienced of having MDMA assisted psychotherapy to treat people with a diagnosis of PTSD. Analysis revealed three major themes: i) ‘Existential Freedom’, ii) ‘Beyond the Cartesian Split’, and iii) ‘A Journey Back in Time’.
Isoform Specific Function of the Metastatic Formin FMNL2
Creators: name: Péladeau, Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Formin
Cancer
FMNL2
Metastatis
Invasion

description: Cancer cell metastasis is induced by actin-dependent cell migration and is affected by cytoskeletal remodelling proteins. FMNL2 is one such protein which promotes colorectal cancer (CRC) cell metastasis and amoeboid style invasion of melanoma cells. FMNL2 mRNA is subject to alternative splicing and studies suggest that the resulting encoded proteins are likely to differ in their regulation, subcellular localization and activity. We identified four FMNL2 isoforms (ITM, YHY, PMR and TQS) expressed in non-invasive (SW480) and invasive (SW620) CRC cells, as well as in highly invasive A375 amoeboid melanoma cells. qPCR data suggests that an “invasive” isoform (TQS) may be preferentially expressed in highly invasive and amoeboid cell lines. Boyden chamber invasion assay results show that FMNL2 knockdown inhibits amoeboid style invasion in two melanoma cell lines and that TQS is the most efficient isoform at rescuing the invasive phenotype. This study provides a further understanding of FMNL2’s role in invasion and metastasis and identifies specific targets for the development of future antimetastatic therapies.
Using genetically encoded biosensors to investigate the cell and cilia cycles in melanoma
Creators: name: Brennan, Louise
Publisher: name: Lancaster University
Year: 2024

description: Melanoma has innate phenotypic plasticity, allowing switching between
 heterogenous cell phenotypes in response to immune therapies, which
 contributes to resistance. These phenotypes closely resemble the
 differentiation trajectory in development, from the early embryo, through
 the neural crest and embryonic melanoblasts, to differentiated
 melanocytes. Primary cilia are protruding microtubule-based organelles
 present on differentiated melanocytes, their loss may be sufficient to
 drive cell cycle re-entry and metastatic progression.

 To investigate ciliary and cell cycle parameters in melanoma cells we
 developed a biosensor that allows discrimination of G1, S and G2/M cell
 cycle phases and the primary cilium by fusing the Fucci(CA) probes
 hCdt1-mCherry and hGeminin-mVenus with cilia localised Arl13b-RFP670.
 PiggyBac was used to integrate the construct into melanoblasts, melanocyte
 and melanoma lines and observe ciliated cells in all cell types.

 The newly developed Arl13b-Fucci(CA) biosensor allows for better cell and
 cilia cycle discrimination and our results suggest that ciliation status
 reflects melanoma differentiation status. The primary ciliome warrants
 further research for melanoma associated targets that could influence
 phenotype switching.

 Simultaneously, we screened cilia genes for association with melanoma
 using TCGA and melanoblast RNAseq data. We found a larger mutation
 frequency in cilia associated genes for melanoma compared to other
 cancers, including breast lung and ovarian. Cilia number and length
 increased with differentiation state of melanoma cell lines, based on MITF
 expression. Analysis of differentiation trajectory in TCGA melanoma data
 revealed a group of cilia genes specifically expressed in an
 undifferentiated subtype, associated with an invasive phenotype: The
 GLIS genes.

 Through genetically encoded biosensors, qPCR, RNAseq and shRNA knockdowns,
 we showed that knockdown of Glis genes resulted in a
 loss of cilia in melanoblasts. Further, we show that GLIS proteins are
 involved in sonic hedgehog signalling.
Perceived Loudness Sensitivity Influenced by Brightness in Urban Forests: A Comparison When Eyes Were Opened and Closed
Creators: name: Hong, Xin-Chen
name: Wang, Guangyu
name: Liu, Jiang
name: Dang, Emily
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Soundscape plays a positive, health-related role in urban forests, and there is a competitive allocation of cognitive resources between soundscapes and lightscapes. This study aimed to explore the relationship between perceived loudness sensitivity and brightness in urban forests through eye opening and closure. Questionnaires and measuring equipment were used to gather soundscape and lightscape information at 44 observation sites in urban forested areas. Diurnal variations, Pearson’s correlations, and formula derivations were then used to analyze the relationship between perception sensitivity and how perceived loudness sensitivity was influenced by lightscape. Our results suggested that soundscape variation plays a role in audio–visual perception in urban forests. Our findings also showed a gap in perception sensitivity between loudness and brightness, which conducted two opposite conditions bounded by 1.24 dBA. Furthermore, we found that the effect of brightness on perceived loudness sensitivity was limited if variations of brightness were sequential and weak. This can facilitate the understanding of individual perception to soundscape and lightscape in urban forests when proposing suitable design plans.
Process modelling with limited data : application studies in waste treatment and pharmaceutical processes.
Creators: name: Wu, Anthony T. H.
Publisher: name: University of Surrey
Year: 2020

description: Model Predictive Control (MPC) is a solution towards more energy-efficient waste treatment without compromising on treatment quality. A key component is the process model describing how the inputs and outputs correlate. MPC uses this model to predict future outputs over a finite horizon to decide on step changes to make at the input. These step changes are made so that the output reaches and maintains at a user specified set point. For MPC to be effective, the process model needs to accurately describe the process behaviour. This is a difficult challenge in waste treatment processes due to a combination of slow response, process complexity, and large disturbances. This research project investigated two research avenues towards developing better modelling techniques. This would result in more accurate models or achieve a sufficiently accurate model with fewer experiments. The first avenue is Constrained Model Identification (CMI). Model identification is an optimisation problem to estimate the model parameters. In CMI, process knowledge from first principles and operator experience is translated into optimisation constraints to aid data-driven model identification. The second avenue is Sequential Optimal Experiment Design (SOED). This uses the concept of measuring a value representing information content of a dataset. Like MPC, SOED uses the model to make output predictions. The expected output response to a sequence of input steps form a dataset, and SOED is an optimisation problem to maximise the information content of that expected dataset, by changing the input step sequence. Once optimised, this step sequence is applied in the next experiment. The third part of this work focused on farm-fed anaerobic digestion. It is a renewable energy technology fuelled by agricultural waste. They rely on government incentives to be profitable, but these incentives have steadily been decreased. This project investigated methods to help farmers in the day-to day operation of the unit, including biogas production estimation, automated fault identification and partial diagnosis.
Le développement de la compréhension des conséquences interpersonnelles des émotions
Creators: name: Hurtubise, Mariève
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: compréhension des émotions
conséquences interpersonnelles
dissimulation
expression
tristesse
colère
théorie de l'esprit

description: Le but de la présente thèse de doctorat est d’examiner le développement de la connaissance des conséquences interpersonnelles des émotions au cours de l’enfance. Le premier objectif de cette thèse est d’examiner le développement de la justesse du raisonnement des enfants lorsqu’ils doivent choisir parmi trois choix de réponses celui qui explique le mieux les conséquences découlant de l’expression et de la dissimulation de la colère et de la tristesse chez leurs pairs. Le deuxième objectif est de mieux comprendre les types d’erreur commise par les enfants dans le contexte de la dissimulation. Deux études ont été menées afin de répondre à ces objectifs. Dans chacune d’elles, des enfants âgés de 5 à 10 ans ont écouté des histoires dans lesquelles des personnages décident d’exprimer ou de dissimuler l’émotion qu’ils ou qu’elles ressentent. L’enfant devait choisir ce que les pairs du personnage principal allaient faire et penser comme suite à l’expression et à la dissimulation de la tristesse et de la colère. Les résultats montrent que, dès le début de la période scolaire, les enfants ont une certaine connaissance des conséquences interpersonnelles de l’expression de la colère et de la tristesse, tant sur le plan du comportement que sur celui des pensées, c’est-à-dire du type d’évaluation qu’une personne est susceptible de faire. Cependant, les enfants ont plus de facilité à choisir correctement les conséquences interpersonnelles de ces émotions lorsque celles-ci sont exprimées plutôt que dissimulées. Les enfants âgés de 8 à 10 ans peuvent toutefois mieux se représenter l’effet que l’expression et la dissimulation d’une émotion peuvent avoir sur la pensée et le comportement d’un autre enfant. Les enfants de 5 à 6 ans ont plus de difficulté à comprendre l’effet trompeur que peut avoir l’expression d’une émotion. Les analyses montrent que le type de dissimulation semble contribuer à la représentation qu’ont les enfants des comportements et des pensées interpersonnels déclenchés par la dissimulation. Les enfants de nos études avaient plus de difficulté à choisir les comportements et les pensées des personnages lorsque le personnage principal de l’histoire neutralisait son émotion. Nos résultats montrent aussi qu’il est plus facile pour l’enfant de se représenter les conséquences interpersonnelles de la dissimulation lorsque le personnage principal connaît moins l’autre personnage.
Resisting Bullying: Narratives of Victims and Their Families
Creators: name: Khanna, Savitri
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Resistance,
Responses
Bullying
Victimization
Narrative Inquiry
Narratives

description: Bullying has severe consequences for school-aged adolescents who have experienced repeated victimization and for the families as well. While there is a considerable body of research on bullying and its effects on victims, very little research has been devoted to studying the experiences and resistance of the targeted young people and their families in the bullying situations. The literature on bullying characterizes victims as unable to defend themselves; this depiction is limited, simplistic, and one-dimensional. This dissertation presents an alternate view, focusing on the experiences and responses of victims and their families. The thesis draws on a poststructural view and a response-based framework to present a new perspective on the victims of bullying—a perspective that contrasts with the common depiction of “helpless, powerless victims” and foregrounds the personal agency of young people who have responded to bullying. Data for this study was collected in the form of narratives from the families and eleven to fifteen year old school adolescents who have been targets of ongoing bullying. The sample consisted of four families and five adolescents. The interview questions were based on Allan Wade’s response-based approach. The participants’ narratives focused on their responses to bullying. Each narrative was read thoroughly for themes related to the skills and the knowledge adolescents have used in responding to peer aggression. Similarly, parents’ narratives were examined for themes of their responses to the bullying of their children. The conclusion from the findings indicated that the parents and adolescents responded to bullying in many small but prudent and resourceful ways.
Tata Kelola Pengetahuan
Creators: name: Wekke, Ismail Suardi
name: Sainuddin, Ibnu Hajar
name: Rajjako, Ardiansyah
name: Harisman, Teguh
Publisher: name: Zenodo
Year: 2020
Subjects: tata kelola
pengetahuan

description: Pola dan alur kerja untuk Tata Kelola Pengetahuan.
Influence of Nanoscale Surface Modifications on the Fatigue Resistance of Medically Relevant Metals
Creators: name: Ketabchi, Amirhossein
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Titanium
Ti-6Al-4V
surface modifications
fatigue resistance
anodization
oxidative nanopatterning
nanotopography

description: With an increasingly aging population, a significant challenge in implantology is the creation of biomaterials that actively promote and accelerate tissue integration while offering excellent mechanical properties. Engineered surfaces with superimposed micro and nanoscale topographies showed great potential to control and direct biomaterial-host tissue interactions. However, these modified surfaces require a careful assessment to prevent potential adverse effects on the fatigue resistance, a factor which may ultimately cause premature failure of biomedical implants. In this context, the surfaces of two widely used biocompatible metals, namely CP Ti and Ti-6Al-4V, were engineered through simple yet efficient chemical treatments which demonstrated the ability to confer exciting new bioactive capacities. The qualitative and quantitative assessments of the fatigue resistance of polished and treated metals were carried out. Results from this study highlight the importance of mechanical considerations in the development and evaluation of nanoscale surface treatments for metallic biomedical implants.
Le processus disciplinaire des prisons du Québec : une histoire de logiques
Creators: name: Chamberland, Carol-Ann
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Processus disciplinaire
prison
logiques de renvoi
isolement
agents correctionnels

description: Partant des déterminants du renvoi soulevés par Zauberman (1982) et tenant compte des particularités du contexte carcéral, nous avons tenté, en effectuant des entrevues semi-dirigées auprès d’agents correctionnels, de comprendre quelles logiques sont à la base de la production de l’isolement disciplinaire, c’est-à-dire celles qui mènent un agent à reconnaitre une situation problématique et à la renvoyer devant le comité disciplinaire. Nos résultats permettent d’effectuer certains constats à l’égard de chacune des étapes du processus disciplinaire et rapportent des recommandations faites par les participants afin d’en améliorer le fonctionnement. Étonnament, l’objectif de punition serait rarement le principal objectif du renvoi d’un acte. Aussi, bien que les déterminants soulevés par Zauberman (1982) s’appliquent aux logiques des agents correctionnels, ceux-ci s’avèrent parfois être davantage déterminants de non-renvoi considérant les particularités du contexte carcéral qui créent certaines singularités telles que l’apparition d’un autre déterminant, celui du poids des règlements et procédures.
How Saudi children evaluate religion-based exclusion.
Creators: name: Alsamih, Munirah
Publisher: name: University of Surrey
Year: 2020

description: Peer exclusion is when a group of children exclude another child or reject his or her request to join them (Gazelle & Druhen, 2009). Peer exclusion affects the child's wellbeing and academic achievement. A number of studies have examined how children evaluate peer exclusion based on group membership, for example of the basis of gender and ethnicity, in the US and Europe. However, little work has been done in the Middle East. Moreover, no work has included parents with their children to test the relationship between parents and children. This thesis examined how Saudi children and their mothers evaluate religion-based exclusion. Five studies were carried out to achieve the aim of this thesis. The main aim of these studies was to examine how Saudi children evaluate the exclusion of in-group members (Muslim, Sunni) and out-group members (Shia, non-Muslim) when the perpetrator of the exclusion was their father or their peers. In the first study, Saudi children (N= 92) residing in Saudi Arabia were interviewed. Children were more likely to accept exclusion of out-group members than in-group members. Also, they were more likely to accept exclusion when it was ordered by their father than if it was ordered by a group of peers. In the second study, mothers (N= 60) residing in Saudi Arabia and children were interviewed. There was a significant mother-child relationship only when discussing the exclusion of out-group members. In the third study, Saudi children residing in the UK were interviewed (N= 76) and the findings were similar to the first study; children were more likely to accept the exclusion of out-group members than in-group members and exclusion by their fathers than by peers. In the fourth study, Saudi mothers and children residing in the UK were interviewed. There was no significant mother-child relationship in the evaluation of religion-based exclusion. The final study compared Saudi children and their mothers in Saudi Arabia with Saudi children and their mothers in the UK. Saudis in Saudi Arabia were more accepting of exclusion than Saudis in the UK. Children in Saudi Arabia and in the UK were more likely to accept exclusion than their mothers. Generally, children and their mothers in Saudi Arabia and in the UK were more likely to accept exclusion by the father than by their peers. In summary, the results of this thesis suggest that Saudi fathers play a vital role in affecting children's and mothers' attitudes. Mothers seem to hold more tolerant attitudes than their children. The findings are discussed in relation to Saudi culture and the literature on transmission of attitudes and intergroup contact.
Accounting for the Distribution of Adverse Birth Outcomes in Ontario: A Hierarchical Analysis of Provincial and Local Outcomes
Creators: name: (:Unkn) Unknown
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: birth
outcomes
adverse
maternal
characteristics
premature
small for gestational age
SGA
stillbirth
spatial cluster
local Moran's I
hotspots
local area
Hierarchical regression analysis
GLIMMIX
smoked
morbidity
health problem
age
older age
teenage
ecologic
individual
education
income
Asian
urban
rural

description: Background: Adverse birth outcomes present a difficult and chronic challenge in Ontario, in Canada and in developed countries in general. Increasing proportions of preterm births, significant regional disparities and the high cost of treating all adverse birth outcomes have focused attention on explaining them and developing effective treatments. Methods: Birth outcomes and maternal characteristics for approximately 626,000 births, about 90% of births in 2005–2009, were linked to small geographic areas throughout Ontario. For each of four adverse outcomes: late preterm, moderate to very preterm, small for gestation age and still births, proportions of total births were calculated for the full province and for each small geographic area. Geographic hotspots of elevated rates were identified for each of the different adverse birth outcomes using the local Moran’s I statistic. Data for nine known ecologic and individual risk factors were then linked to the areas. Hierarchical regression analysis was used to model each of the outcomes for the full province and for dispersed local areas. The resulting models for the different outcomes were contrasted. Results: Significant geographic hotspots exist for each of the four outcomes. Hotspots for the different outcomes were found to be largely spatially exclusive. For like outcomes, predictive models differed markedly between local areas (i.e. local groups of hotspots) as well as between full-province and local areas. Ecologic level variables played a strong role in all models; the influence of individual level risk factors was consistently modified by ecologic risk factors except for small for gestational births. Conclusions: The finding of significant hotspots for different adverse birth outcomes indicates that certain geographic areas have aetiologies or patterns of predictors sufficient to create significantly elevated levels of particular outcomes. The finding that hotspots for the different adverse outcomes are largely exclusive implies that the aetiologies are specific; i.e., those that are sufficient to create significantly higher levels for one outcome do not also create significantly higher levels of others. The consistently strong role of ecologic level risk factors in modifying individual level risk factors implies that contextual characteristics are an important part of the aetiology of adverse birth outcomes. Differences in local area models suggest the existence of location-specific (rather than universal) aetiologies. The findings support the need for more careful attention to local context when explaining birth outcomes.
A thesis of clinical research and practice: Part A: A phenomenological exploration of non-carrying mothers’ in same-gender relationships experiences of a psychologically traumatic birth; Part B: Partners’ experiences of primary and secondary tokophobia: A qualitative systematic review; Part C: Summary of clinical practice and assessments
Creators: name: Williams, Sophie
Publisher: name: University of Surrey
Year: 2024
Subjects: Clinical Psychology
LGBTQ Studies
Mental Health
Perinatal Health
Qualitative Methods (social sciences)

description: Despite growing interest into perinatal experiences, partners’ needs are overlooked in research, services, and policy. Both papers contribute novel insights into non-birthing parents’ experiences of birth trauma and tokophobia, inclusive of fathers and lesbian, gay, bisexual, transgender, and queer+ non-birthing parents. This holds the potential to inform support within perinatal services, which is timely given the recent expansion of Maternal Mental Health Services in England which currently does not offer support to partners. The two papers emphasise socio-cultural and political contexts as pivotal to de-pathologising individual ‘difficulties’, instead viewing them as measured responses to multi-layered situations, without disregarding the need for professional support where appropriate. Part A presents a qualitative empirical study, which explored experiences of psychologically traumatic birth in non-carrying mothers in same-gender relationships, and how they made sense out of this experience. Semi-structured interviews with eight Black lesbian first-time mothers were conducted and analysed using Interpretive Phenomenological Analysis. Four themes were developed: ‘anticipated and realised threats’, ‘navigating identities and roles in the transition to motherhood’, ‘importance of feeling understood and accepted by others’ and ‘adapting to a new normal’. Part B presents a qualitative systematic review which sought to understand partners’ experiences of primary or secondary tokophobia, inclusive of non-birthing fathers and co-parents, and other partners. Following a systematic search of international literature, four studies met inclusion, reported across six articles. Applying the thematic synthesis approach, three themes were developed:  ‘heightened awareness of threat towards life’, ‘roles, duties, and expectations as a partner’, and ‘finding ways to alleviate the extreme fears’. Both papers highlight unique factors that partners experience in relation to birth trauma and tokophobia. Important clinical and research recommendations are outlined, including the need for more research into non-birthing parents’ experiences, greater consideration of intersectionality, and the importance of supporting both parents across the perinatal period.
My Personal Paso Doble: An Autoethnographic Performance “Starring” the Hidden Curriculum of Confidence Within International Latin DanceSport
Creators: name: Pasco-Pacheco, Crestina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Hidden curriculum
Implicit lessons
Intrapersonal development
Interpersonal development
DanceSport
Confidence
Autoethnography

description: Using an autoethnographic methodology in tandem with a social constructivist lens, the purpose of this study is to critically inquire into the implicit lessons learned by competitive Latin dancers from their participation in the hidden curriculum of DanceSport culture. Additionally, this research looks to outline the intrapersonal and interpersonal development experienced by DanceSport dancers. Doing so, I focus on the voice of the dancers in the exploration of International DanceSport studios and competition floors as sites of informal and non-formal education, particularly in relation to the hidden curriculum of DanceSport. My role as an autoethnographic researcher and participant in this study was to collect data through multimodal expression, as well as ongoing dialogue with participants. As researcher and participant, I completed the same hands-on task and interview questions as participants, and journaled to explore thoughts concerning my DanceSport experience. Information obtained from interview transcripts and journal entries has been organized, coded, and analyzed creating themes. A description and interpretation of the findings uncovers the unifying theme(s) of six narratives. Narrative inquiry reveals that the hidden curriculum of DanceSport is the awakening and development of dormant confidence as dancers acquire implicit lessons pertaining to the development of intra and interpersonal knowledge. A discussion exploring the unique ways this dissertation contributes to the DanceSport community and body of literature concludes this study. This is alongside an assessment as to the culture’s ability to meet current goals of formal education, and the potential Latin DanceSport has to be used as an educational tool in the development of student well-being.
A thesis of clinical research and practice: Part A: Exploring the experiences of postpartum depression amongst Muslim mothers: a systematic review of qualitative studies; Part B: Ramadan and the Iftar meal: a qualitative exploration of signs of disordered eating in Muslim men and women living in the UK; Part C: Summary of Clinical Practice and Assessments
Creators: name: Zubair, Alina Kamran
Publisher: name: University of Surrey
Year: 2024
Subjects: Muslim; eating disorders; disordered eating; Ramadan; Iftar; qualitative; Islam

description: The Muslim population is growing worldwide, yet little of the literature has focused on exploring experiences of Muslims in relation to mental health difficulties, such as postpartum depression and signs of disordered eating. As such, this thesis aimed to fill some gaps within the literature by exploring the experiences of postpartum depression and signs of disordered eating within Muslim populations. Part A of this portfolio presents a systematic review exploring the experiences of postpartum depression amongst Muslim mothers residing in Muslim minority and majority countries. The findings of this review indicate that there are some broad similarities between Muslim mother’s experience of postpartum depression when living in Muslim majority versus Muslim minority countries, although individual experiences are likely to differ due to factors such as family relationships and immigration status. Part B of the portfolio presents an empirical paper that qualitatively explored the experiences of Muslim men and women with low-medium self-regulation of eating regarding Ramadan and the Iftar meal. Fasting during Ramadan is an Islamic practice which involves intermittent fasting. Some studies have found intermittent fasting to be a risk factor for the development of signs of disordered eating and those with low-medium self-regulation of eating are more at risk. Little is known about the effects of religious fasting and breaking the fast (the Iftar meal) on signs of disordered eating. The findings highlight the experiences that led to some participants displaying signs of disordered eating during Ramadan. Findings also suggest that the excess of food available at Iftar was not always easily managed, and that feelings of shame were prevalent when it came to overeating at Iftar.
Prevotella copri Cpf1 family proteins-PcoCpf1 mediated Knockout of DGK to improves Antitumor Activities of TCR-T
Creators: name: 郭强(Guo Qiang)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Raw sequence reads
Genome sequencing
Other
human PBMC
Tumor Immunotherapy

description: The application of gene editing in cell therapy brings hope to improve the effect of tumor suppression, and the continuous development of new gene editing tool enzymes has improved the scope of application and safety, further increasing the application of gene editing technology in the field of cell therapy potential. This study screened and identified the uncharacterized gene editing enzyme PcoCpf1 , which has more targetable sites and higher editing efficiency in some sites than spCas9 and cpf1. Using the BEST6 enzyme, we knocked out the negative regulatory targets of T cell function in TCR-T cells, in order to obtain TCR-T with improved tumor suppression effect.
MPEC 2024-L123 : 2024 LO3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 LO3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Patients with pretreatment leukoencephalopathy and older patients have more cognitive decline after whole brain radiotherapy
Creators: name: Chan, Matthew
name: Ferguson, David
name: Ni Mhurchu, Elaine
name: Yuan, Ren
name: Gondara, Lovedeep
name: McKenzie, Michael
name: Olson, Robert
name: Thiessen, Brian
name: Lalani, Nafisha
name: Ma, Roy
name: Nichol, Alan
Publisher: name: BioMed Central
Year: 2020

description: Purpose: To investigate predictors of cognitive decline after whole brain radiotherapy (WBRT) for brain metastases. Methods: A secondary analysis of a phase 2 clinical trial was conducted in patients who received stereotactic radiosurgery for 1–10 brain metastases and WBRT (NCT01046123). The Montreal Cognitive Assessment (MoCA) was performed at baseline and every 3 months after WBRT. Baseline T2-weighted fluid attenuation inversion recovery magnetic resonance imaging was independently assessed by two neuroradiologists for the presence of white matter hyperintensities (WMH) using the Fazekas visual rating scale. WMH were also manually segmented for volumetric analysis. Univariable and multivariable logistic regression were used to test the association between baseline variables and MoCA score decline. Results: Forty-six patients survived ≥ 3 months after treatment. Age (OR 1.12 (1.04–1.21), p < 0.01), baseline WMH volume (OR 1.20, 95% CI 1.06–1.52, p = 0.02) and baseline Fazekas score ≥ 3/6 (OR 6.4, 95% CI 1.7–24.7, p < 0.01) were predictive of MoCA score decline. In multivariable analysis, age was the only significant predictor of MoCA decline. However, all three patients with pre-treatment leukoencephalopathy (Fazekas score = 6/6) had notable adverse outcomes due to cognitive impairment: one required full-time home nursing support and two were institutionalized. Conclusion: A greater decline in cognition after WBRT was observed in older patients and patients with a higher baseline WMH burden. Although this study is small and hypothesis-generating, we propose that radiation oncologists should exercise caution in prescribing WBRT if leukoencephalopathy is present on pre-treatment imaging. Trial Registration: clinicaltrials.gov identifier NCT01046123. First posted January 11, 2010. https://clinicaltrials.gov/ct2/show/NCT01046123
Stochastic modelling for energy efficient supercomputing
Creators: name: Dinh, Tuan Van
Publisher: name: Swinburne
Year: 2024

description: This thesis studies mathematical stochastic modelling frameworks to improve the energy efficiency in cluster computing systems, which are facing the challenge of growing energy consumption due to the fast-increased computing demand from phenomenon such as Big Data or the Internet of Things. These frameworks are developed with the reference to the analysis of empirical data collected from real computing systems. This work is a contribution to the engineering effort to make the modern Information and Communication Technology infrastructure more sustainable.
Drosophila Suppressor/Enhancer Screen to Identify Novel LRRK2 Interactors
Creators: name: Abuaish, Sameera
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Drosophila
LRRK2
Parkinson's Disease
Genetic screen

description: Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta. The mechanism by which these DA neurons die is still unclear and under investigation. Although mostly idiopathic, about 10% of PD cases have shown familial inheritance. Mutations in leucine-rich repeat kinase 2 (LRRK2), a large multi-domain protein with unknown physiological and pathological roles, have been linked to PD cases of autosomal dominant inheritance. A PD Drosophilamelanogaster model over expressing the human LRRK2(I2020T) kinase mutant using the GAL4/UAS system has shown a loss of DA neurons and locomotor deficiency. Additionally, ectopic overexpression of human LRRK2 in the eye caused a damaged eye phenotype characterized by roughness of the surface, loss of pigmentation and presence of black lesions (Venderova Ket. al., 2009). The presence of this identifiable eye phenotype has allowed us to perform a suppressor/enhancer screen to identify possible genetic interactors of LRRK2. The LRRK2(I2020T) transgenic flies were crossed with genomic deficiency lines and the eye phenotype screened for either suppression or enhancement. Twenty-two genes, which are implicated in a variety of biological processes, have been identified thus far. Fourteen of these 22 interacting genes were assessed in the DA neurons of the D.melanogaster model. This functional screen is a rapid method to provide us with potential genetic interactions between LRRK2 and other genes, which will in turn, aid in elucidating the functional role of LRRK2 in PD pathology.
Adipocytokines and their relationship to obesity and endometrial cancer
Creators: name: Ray, Irene
Publisher: name: University of Surrey
Year: 2024
Subjects: Adipocytokines
Insulin-like Growth Factors
Endometrial Cancer
Inflammation
Obesity

description: The incidence of uterine cancer has surged by 55% in the UK since the early 1990s, with 34% of endometrial cancer cases linked to obesity. Obesity triggers chronic inflammation and insulin resistance, promoting cancer development through adipocytokines and the insulin-like growth factor (IGF) system. These factors are potential biomarkers and therapeutic targets for endometrial cancer; however, no established markers exist for screening, diagnosis, ortreatment monitoring. This research was undertaken as an exploratory hypothesis-generating study to assess the variations in the levels of six biomarkers (adiponectin, leptin, IL6, TNFα, IGF1, and IGF2) among individuals with endometrial cancer (n=50) and those with benign gynaecological conditions (n=50). Additionally, the study aimed to explore the associations between these marker levels, obesity, and tumour characteristics. 6-months post-surgery marker levels were also measured to assess the effect of treatment. Low adiponectin indicated a 35.8% increase in endometrial cancer risk. Post-menopausal women with endometrial cancer had elevated IGF levels, opposite to control patients having reduced IGF levels, suggesting an impact of endometrial cancer and menopause on the IGF system. Adipocytokine and IGF levels showed an inverse trend six months post-surgery.Furthermore, expressions of these markers and their receptors were evaluated in endometrial cancer tissue, fat tissue, and lymph nodes. Adiponectin and leptin demonstrated higher expression in fat tissue and lymph nodes than in endometrial cancer tissue. No correlation was found between ELISA and PCR results, suggesting circulating marker levels were independent of their expression in endometrial tissue. Adiponectin receptors, ADIPOR1 and ADIPOR2 exhibited differential expression patterns in endometrial cancer and normal endometrium, with opposite correlations to prognostic markers. Notably, a three-way interaction involving adiponectin, lympho-vascular space invasion, and lymph node cancer status was found that necessitates further revalidation for potential pathophysiological associations. This comprehensive study contributes insights into potential biomarkers, their interplay, relative abundance in blood and various tissues and their clinical implications in endometrial cancer.
Mengenang Syekh Yusuf, Ulama Pejuang Lintas Benua
Creators: name: Ikhsan, Muh
name: Rajjako, Ardiansyah
name: Wekke, Ismail Suardi
Publisher: name: Zenodo
Year: 2020
Subjects: syekh yusuf
ulama pejuang
lintas benua

description: Pelaksanaan peirngatan harlah Syekh Yusuf, 3 Juli 2020.
A Voice of One’s Own: An Investigation of Developing World Agency in Oxfam International’s 2009 Climate Change Campaign
Creators: name: Low, Alicia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Content Analysis
Critical Discourse Analysis
Agency
Non-governmental agencies
Postcolonialism

description: Climate change is an issue that is increasingly being adopted into various NGO campaigns. Drawing on a theoretical framework that is grounded in post-colonialism and subaltern studies, this thesis investigates representations of agency in the climate change discourse of Oxfam International. The central research question guiding the study is: To what extent do developing world people and countries have agency in Oxfam International’s 2009 climate change campaign? The methodological approach used to address this question combines content analysis and critical discourse to analyze 105 documents published by Oxfam in the lead up to the 2009 U.N. Climate Change conference in Copenhagen, Denmark. The findings reveal that that developing world subjects tend to possess less speaking space and to be represented with less agency than their developed world counterparts.
Predictors of successful modulation of emotion-related networks in a study of real-time f-MRI neurofeedback with adolescent females.
Creators: name: Staunton, Graham P.
Publisher: name: University of Surrey
Year: 2020

description: Neurofeedback using real-time functional magnetic resonance imaging is a technique which supports participants to modify their own brain activity for therapeutic benefit. It has gained attention for its potential as an alternative intervention for a range of mental health issues. However, there is considerable variance in participant success. Understanding the factors involved in this variance could assist with the prediction of outcomes and personalised support. Here, the results of a literature review on this topic and a subsequent secondary data analysis for a therapeutically significant population are presented. Specifically, in Zich and colleagues (under review), adolescent female participants (n = 28) learned to modulate healthy patterns of emotional regulation in a study which collected pre-intervention data on variables to do with mood, IQ, development, initial functional connectivity (IFC) and control beliefs. The current analysis aimed to predict outcomes based on these measures. Differences between participants who improved (learners) and declined (non-learners) in performance were also explored. Principal components analysis reduced the measures into the factors ‘Control’ (mood and control beliefs) and ‘Maturity’, (age, puberty and IQ). Multiple regression analysis with these factors and IFC did not significantly predict performance or change. However, IFC significantly predicted performance (β =-415.75, p = .004, CI = -415.75, -92.37). At a group level, non-learners initially performed above the mean but could not sustain this success. Learners had significantly higher thought control ability and verbal comprehension scores than non-learners. These results and other findings from the literature require confirmation with larger samples. It was concluded that predicting outcomes for individuals may be challenging as individual factors are likely to have complex roles, though initial connectivity readings may predict performance effectively. Implications include the potential for personalised support to improve outcomes for non-regulators. Individual factors should be routinely considered to develop the efficacy of neurofeedback.
Euristica del senso. Iconic turn e semiotica dell'immagine
Creators: name: Mengoni, Angela
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: Taking cue from the epistolary exchange between Gottfried Boehm and Tom Mitchell, the article explores the relationship between the so-called Bildkritik and the visual semiotics. Rather than focusing on the explicit quotation of semiotic concepts or authors, the paper proposes to examine the heuristic approach to the image that characterizes both the analytical dimension of the Bildkritik and the semiotics of the image developed by the French generative semiotics.Taking into account the immanent approach of both traditions and some key-operators (such as ‘iconic difference’ and ‘sémiotique plastique’), the acknowledgement of an active sense-generating capability of the ‘visual’ will emerge as a common feature.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)