cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of the Pumilio RNA-binding protein Puf4 in the regulation of the fission yeast cell cycle
Creators: name: Abdelaziz, Ahmed E. M.
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Pumilio protein
subject: Puf4
subject: RNA binding proteins
subject: Post-transcriptional gene regulation
subject: Cell cycle control
subject: Schizosaccharomyces pombe
subject: Fission yeast
subject: Biology--Genetics
subject: Biology--Microbiology
subject: Biology--Molecular

description: The Puf family of RNA-binding proteins consists of highly conserved posttranscriptional regulators present throughout eukaryotes from yeast to human. Puf proteins recognize their target mRNAs through a conserved Pumilio homology domain (PUM-HD) at the 3'-untranslated region (3'UTR), usually at a site containing a 5'-UGUR-3' core sequence. The consequence of Puf binding can result in posttranscriptional regulation of target mRNAs through stability, translational initiation, or intracellular localization. Puf proteins are involved in several types of human diseases such as cancer by controlling the levels of mRNAs encoding proteins involved in apoptosis, proliferation, and cell cycle control. In the fission yeast Schizosaccharomyces pombe, seven nonessential genes encode for classical Puf proteins. However, the biological function and target mRNAs of these Puf proteins remain elusive. Here, we focus on the functional analysis of the puf4+ gene in S. pombe. Deletion of puf4+ resulted in slightly shorter cells with a higher septation index compared to wild-type cells, while overexpression of puf4+ caused a cell elongation phenotype, indicating a cell cycle defect. Microscopic examination of puf4 overexpression cells and genetic interactions with cell cycle mutants revealed that Puf4 plays a role at the G2-M transition and regulation of entry into mitosis. Furthermore, loss of puf4+ caused hypersensitivity to hydroxyurea, suggesting an additional role in DNA replication. Transcriptome profiling of the puf4 overexpression strain, RNA-immunoprecipitation sequencing, bioinformatics, and genetic interaction analysis were used to identify putative target mRNAs potentially degraded or stabilized by Puf4. Furthermore, proteomic analysis using Tandem mass spectrometry and co-immunoprecipitation were also performed and revealed interacting protein candidates potentially involved in Puf4-mediated posttranscriptional regulation. The mRNA encoding for the HIRA complex interacting protein Hip3 involved in chromatin remodeling was among the putative potential targets of Puf4 contributing to the cell elongation phenotype of puf4+ overexpression. Puf4 degrades hip3+ mRNA by binding to the 3’UTR and promoting deadenylation and exoribonuclease activity. In addition, the 14-3-3 proteins Rad24 and Rad25 were shown to physically interact with Puf4 and colocalize in cytoplasmic granules in response to hydroxyurea. This study provides novel insights into the regulatory activity and biological roles of the S. pombe Pumilio protein Puf4.
Additional file 1 of Individual-level patterns of resource selection do not predict hotspots of contact
Creators: name: Yang, Anni
name: Boughton, Raoul
name: Miller, Ryan S.
name: Snow, Nathan P.
name: Vercauteren, Kurt C.
name: Pepin, Kim M.
name: Wittemyer, George
Publisher: name: figshare
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Materials for Individual-level patterns of resource selection do not predict hotspots of contact.
Oil Sands Technology Pathway Evaluation Using Life Cycle Assessment and Mathematical Optimization
Creators: name: Dadashi Forshomi, Zainab
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Life Cycle Assessment
subject: Optimization
subject: Process Integration
subject: Engineering--Chemical

description: Oil sands producers must improve the environmental performance of their operations to remain competitive in the energy sector in a carbon constrained world. These improvements include both incremental changes in the existing operation to make it more efficient (e.g., by applying process integration techniques) or fundamental changes to the operation (e.g., by adopting emerging technologies). However, an individual company will consider regulatory requirements and economic feasibility prior to making decisions about investments in these technologies. This thesis investigates the potential improvements in oil sands operations through both incremental efficiency improvements (i.e., lower energy consumption per unit of energy produced) and fundamental changes in their operations. In the first part of the thesis, cost and energy savings opportunities in Steam Assisted Gravity Drainage (SAGD) (an oil sands extraction and recovery process) are assessed by applying process integration techniques through the sequential application of a water treatment system optimization followed by conventional energy pinch analysis (incremental improvement). In the second part of the thesis, the focus is on exploring fundamental improvements in the oil sands sector and identifying the optimal technology pathways for oil sands production and processing with respect to economic and environmental objectives. A comprehensive techno-economic framework is developed that considers all technological and economic input parameters that affect the performance of the oil sands supply chain in terms of total cost, total energy consumption and GHG emissions. This framework is used to: 1) find the technical, economic and policy conditions under which emerging oil sands technologies become competitive alternatives in global crude oil markets, and 2) investigate the prospect of reaching Canada’s climate goals (as it relates to the oil sands sector) by implementing available emission reduction solutions while maintaining oil sands production capacity at the current or increased level in the next three decades. The results of this study help oil sands producers to better understand the long-term effects associated with the use of existing and emerging oil sands technologies. In addition, the results inform short- and long-term investment decision making in oil sands sector under various scenarios with different combinations of input parameters.
Beyond "Meeting Them Where They Are At" : How Nursing Students Conceptualize Harm Reduction In Their Practice With People Who Use Drugs
Creators: name: Denis-Lalonde, Dominique B.
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: harm reduction
subject: nursing education
subject: illegal drug use
subject: social care
subject: undergraduate nurses
subject: social justice
subject: drug policy
subject: drug addiction
subject: substance use
subject: Health Sciences--Nursing
subject: Health Sciences--Public Health
subject: Education--Curriculum and Instruction
subject: Education--Higher

description: This thesis presents findings from a qualitative study that explored how final year nursing students conceptualized harm reduction as a part of their practice with people who use drugs. The research was conducted using a critical social theory lens informed by the work of Habermas (1972; 1984). Data were collected in semi-structured interviews with 11 undergraduate nursing students from a western Canadian university. Data analysis was undertaken using the thematic analysis method developed by Braun and Clarke (2006). Three themes and nine sub-themes demonstrate the complex influences involved in the conceptualization of harm reduction among the participants. Participants expressed that harm reduction was congruent with nursing practice and that conceptually, harm reduction was inherent to their understanding of the profession. While participants seemed to have integrated the concept of harm reduction with their practice, their diverse experiences and identities influenced their perspectives. Contextually, these perspectives caused continued tensions for participants as they navigated questions about drug use stigma, the nature of drug use, the scope of the nurse, and the real-world application of their nursing education. These interconnected influences occurred against a backdrop of critical societal and systemic issues. Participants were negotiating oppressive systems and systemic norms, which affected their perspectives towards harm reduction and the care of people who use drugs. Participants enthusiastically perceived nurses as capable advocates and agents of change, yet they focused on individual contributions and abilities rather than collective efforts and progress. This study’s findings, reflected in four recommendations, contribute to the evidence required for educators to critically explore and prioritize educational approaches that support HR as nursing practice.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (21)]
Creators: name: Ribaldus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1061
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Ribaldus, Sohn des verstorbenen Osbertus von Dovaria, schenkt dem Bistum Cremona, Güter in Maleo, die er von Rogerius, Sohn des verstorbenen Lanfrancus aus Maleo, erhalten hatte
An Order-Complexity Model for Aesthetic Quality Assessment of Homophony Music Performance
Creators: name: Jin, Xin
name: Zhou, Wu
name: Wang, Jinyu
name: Xu, Duo
name: Rong, Yiqing
name: Sun, Jialin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Sound (cs.SD)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Multimedia (cs.MM)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Although computational aesthetics evaluation has made certain achievements in many fields, its research of music performance remains to be explored. At present, subjective evaluation is still a ultimate method of music aesthetics research, but it will consume a lot of human and material resources. In addition, the music performance generated by AI is still mechanical, monotonous and lacking in beauty. In order to guide the generation task of AI music performance, and to improve the performance effect of human performers, this paper uses Birkhoff's aesthetic measure to propose a method of objective measurement of beauty. The main contributions of this paper are as follows: Firstly, we put forward an objective aesthetic evaluation method to measure the music performance aesthetic; Secondly, we propose 10 basic music features and 4 aesthetic music features. Experiments show that our method performs well on performance assessment.
Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia
Creators: name: Timashev, Serge F.
name: Panischev, Oleg Yu.
name: Polyakov, Yuriy S.
name: Demin, Sergey A.
name: Kaplan, Alexander Ya.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Medical Physics (physics.med-ph)
subject: Biological Physics (physics.bio-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: We apply flicker-noise spectroscopy (FNS), a time series analysis method operating on structure functions and power spectrum estimates, to study the clinical electroencephalogram (EEG) signals recorded in children/adolescents (11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical Sciences. The EEG signals for these subjects were compared with the signals for a control sample of chronically depressed children/adolescents. The purpose of the study is to look for diagnostic signs of subjects' susceptibility to schizophrenia in the FNS parameters for specific electrodes and cross-correlations between the signals simultaneously measured at different points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes at locations F3 and F4, which are symmetrically positioned in the left and right frontal areas of cerebral cortex, respectively, demonstrates an essential role of frequency-phase synchronization, a phenomenon representing specific correlations between the characteristic frequencies and phases of excitations in the brain. We introduce quantitative measures of frequency-phase synchronization and systematize the values of FNS parameters for the EEG data. The comparison of our results with the medical diagnoses for 84 subjects performed at NCPH makes it possible to group the EEG signals into 4 categories corresponding to different risk levels of subjects' susceptibility to schizophrenia. We suggest that the introduced quantitative characteristics and classification of cross-correlations may be used for the diagnosis of schizophrenia at the early stages of its development.
description: 36 pages, 6 figures, 2 tables; to be published in "Physica A"
The radio core and jet in the broad absorption line quasar PG 1700+518
Creators: name: Yang, J.
name: Wu, F.
name: Paragi, Z.
name: An, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The blue-shifted broad absorption lines (BAL) or troughs are observed in Active Galactic Nuclei (AGNs) when our line of sight is intercepted by a high speed outflow (wind), likely originating in the accretion disc. The outflow or wind can shed light on the internal structure obscured by the AGN torus. Recently, it has been shown that this outflow is rotating in the BAL quasar PG 1700+518, further supporting the accretion disc origin of the wind. With the purpose of giving independent constraints on the wind geometry, we performed high-resolution European VLBI Network (EVN) observations at 1.6 GHz in 2010. Combining the VLBI (Very Long Baseline Interferometry) results with the Very Large Array (VLA) archival data at 8.4 GHz, we present its jet structure on scales of parsec (pc) to kiloparsec (kpc) for the first time. The source shows two distinct jet features in East-West direction with a separation of around 4 kpc. The Eastern feature, which has so far been assumed to hide the core, is a kpc-scale hot spot, which is completely resolved out in the EVN image. In the western jet feature, we find a compact jet component, which pinpoints the position of the central black hole in the galaxy. Jet components on both sides of the core are additionally detected in the Northwest-Southeast direction, and they show a symmetric morphology on scale of <1 kpc. This two-sided jet feature is not common in the known BAL quasars and indicates that the jet axis is far away from the line of sight. Furthermore, it is nearly parallel to the scattering plane revealed earlier by optical polarimetry. By analogy to polar-scattered Seyfert 1 galaxies, we conclude that the jet likely has a viewing angle around 45 degree. The analogy is further supported by the recent report of significant cold absorption in the soft X-rays, a nearly unique feature to polar-scattered Seyfert galaxies.
description: Accepted for publication in MNRAS Letters, 5 pages, 1 figures
Assessing Health Care Costs, Treatment Patterns, and Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis and their Caregivers.
Creators: name: Grazziotin Lago, Luiza R.
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: juvenile idiopathic arthritis
subject: costs
subject: treatment patterns
subject: health-related quality of life
subject: health utility scores
subject: care-related quality of life
subject: Health Sciences--General

description: Juvenile idiopathic arthritis (JIA) is an umbrella term that encompasses all forms of arthritis with onset before the age of 16 years and symptoms that persist for more than 6 weeks for which the cause is unknown. JIA can significantly affect the quality of life of children and their families, and the disease and its treatment can increase the economic burden for the health care system and families.This PhD thesis was focused on a research program that addressed four gaps in the literature: 1) assessment of the overall and JIA-related health care resource utilization and associated costs before and after rheumatology care; 2) evaluation of JIA treatment prescription patterns; 3) studies measuring health state utility scores of patients with JIA across their lifespan, including children, adults, and adolescents; and 4) measurement of caregiver health-related quality of life (HRQoL) and care-related quality of life (CRQoL) and investigation of the relationship of those measures with child HRQoL and other influencing factors.We conducted four studies to address those gaps. Two retrospective cohort studies using electronic medical records and administrative databases to assess health care resource use and costs, and sequences of treatment prescriptions in children with JIA in Canada, respectively. Our findings reveal that the care pathway for children with JIA including health care resource utilization, costs, and treatment prescription patterns can be expensive, and complex – and varies by JIA subtype. We then performed a systematic review, which was the first review seeking to identify and assess health utility scores in children, adolescents, and adults with history of JIA. Finally, our last study was the first to assess care-related quality of life in caregivers of children with JIA, and to evaluate factors associated with caregiver care- and health-related quality of life, which highlighted the need for an encompassing family-centred approach of care that goes beyond achieving inactive disease.
Additional file 1 of A systematic literature review on direct and indirect costs of triple-negative breast cancer
Creators: name: Rezaei, Sadeq
name: Babaei, Majid
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Interplay between ferromagnetism, surface states, and quantum corrections in a magnetically doped topological insulator
Creators: name: Zhang, Duming
name: Richardella, Anthony
name: Rench, David W.
name: Xu, Su-Yang
name: Kandala, Abhinav
name: Flanagan, Thomas C.
name: Beidenkopf, Haim
name: Yeats, Andrew L.
name: Buckley, Bob B.
name: Klimov, Paul V.
name: Awschalom, David D.
name: Yazdani, Ali
name: Schiffer, Peter
name: Hasan, M. Zahid
name: Samarth, Nitin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The breaking of time-reversal symmetry by ferromagnetism is predicted to yield profound changes to the electronic surface states of a topological insulator. Here, we report on a concerted set of structural, magnetic, electrical and spectroscopic measurements of \MBS thin films wherein photoemission and x-ray magnetic circular dichroism studies have recently shown surface ferromagnetism in the temperature range 15 K $\leq T \leq 100$ K, accompanied by a suppressed density of surface states at the Dirac point. Secondary ion mass spectroscopy and scanning tunneling microscopy reveal an inhomogeneous distribution of Mn atoms, with a tendency to segregate towards the sample surface. Magnetometry and anisotropic magnetoresistance measurements are insensitive to the high temperature ferromagnetism seen in surface studies, revealing instead a low temperature ferromagnetic phase at $T \lesssim 5$ K. The absence of both a magneto-optical Kerr effect and anomalous Hall effect suggests that this low temperature ferromagnetism is unlikely to be a homogeneous bulk phase but likely originates in nanoscale near-surface regions of the bulk where magnetic atoms segregate during sample growth. Although the samples are not ideal, with both bulk and surface contributions to electron transport, we measure a magnetoconductance whose behavior is qualitatively consistent with predictions that the opening of a gap in the Dirac spectrum drives quantum corrections to the conductance in topological insulators from the symplectic to the orthogonal class.
description: To appear in Phys. Rev. B
Repeated bout effect and musculoskeletal loading during prolonged downhill running
Creators: name: Khassetarash, Arash
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Running
subject: downhill
subject: biomechanics
subject: bone
subject: Health Sciences--General
subject: Applied Mechanics

description: Running is one of the most common forms of exercise to maintain physical activity and health. Despite decades of research in the field of running biomechanics, the rate of running-related injuries remains high. A vast majority of studies investigating running biomechanics have focused on level running. However, recreational running on urban and rural terrains frequently consists of uphill and downhill running. Owing to high eccentric muscular contraction, downhill running is known to induce muscle damage and symptoms of delayed onset muscle soreness that is generally attenuated during and after a subsequent downhill running bout; a phenomenon known as the repeated bout effect. The primary objective of this thesis was to understand the physiological and biomechanical consequences of an unaccustomed eccentric-biased downhill running bout as well as how the repeated bout effect mediates these consequences. A series of studies were conducted using a model of two prolonged downhill running bouts separated by three weeks. We observed that an unaccustomed downhill run caused substantial neuromuscular fatigue (i.e., central and peripheral fatigue) that persisted up to 48 hours after the initial bout. A repeated bout effect manifested as less sever neuromuscular fatigue following the second downhill run, which was likely due to neural adaptation (i.e., less central fatigue). A repeated bout effect was also observed for downhill running biomechanics, where changes in duty factor and knee quasi-stiffness were attenuated over the course of the second bout compared to the first bout. Changes to bone strain at the lower-extremity over the course of the downhill run were then estimated using combined musculoskeletal-finite element modeling. We observed that the neuromuscular fatigue associated with prolonged downhill running did not impact tibial-fibular strains. The findings from this thesis provide new and important insight to our current understanding of the repeated bout effect in unaccustomed eccentric-biased downhill running as well as the influence of neuromuscular fatigue on bone strain during a prolonged downhill run.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 13 (11)]
Creators: name: , Nicola
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1271
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Nicola, genannt Panzia, Sohn des verstorbenen Jacobus de Zobio aus Como, beglaubigt, von Guillelmius Lauizarius, Abt des Klosters St. Habondii in Como, einen Geldbetrag erhalten zu haben.
Assimilation of carbon and nitrogen by microbial mats from alkaline soda lakes
Creators: name: Liu, Yihua
Publisher: name: Graduate Studies
Year: 2020
Subjects: subject: Environmental Sciences
subject: Biogeochemistry
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Biology--Ecology
subject: Biology--Bioinformatics
subject: Biology--Microbiology

description: Background:Soda lakes are extreme terrestrial ecosystems characterized by high pH, alkalinity, and sodium carbonate concentration. Despite the extreme environment, soda lakes host diverse microbial communities with high primary productivity, carried out by fast-growing phototrophic microbes such as cyanobacteria. In Goodenough Lake, a soda lake on the Cariboo Plateau in BC Canada, carbon isotope analysis indicated that the photosynthetic rate but not bicarbonate availability controlled carbon dioxide assimilation. However, the roles of individual cyanobacteria populations in carbon fixation remain unknown. Despite the rapid growth of microbial mat communities, common nitrogen sources, ammonium and nitrate, were detected only occasionally and in trace amounts in lake water. Mat communities may use alternative nitrogen sources like urea and dinitrogen gas as enzymes for urea assimilation and dinitrogen fixation were highly expressed.Objective:The objective is to measure carbon and nitrogen assimilation by microbial populations in mat communities.Approaches:Incubation of microbial mats from Goodenough Lake with heavy stable isotope labelled bicarbonate, and nitrogen sources, followed by isotope ratio mass spectrometry and proteomics.Results and conclusions:Over 90 different microbial populations were detected in microbial mat communities using proteomics. The sampled mat microbial communities were different from each other, even if samples were close together, but the most abundant populations were the same across samples. The two most abundant cyanobacterial populations exhibited different carbon fixation dynamics, and their abundance was negatively correlated, suggesting that they occupy different ecological niches. Among nitrogen sources, urea was consumed at the highest rate, followed by ammonia. The nitrate consumption rate was much lower, and the fixation of nitrogen was not detected. Urea was consumed mainly during the day. Rates for nitrate and ammonia consumption were similar during the day and the night.
Holographic View on Quantum Correlations and Mutual Information between Disjoint Blocks of a Quantum Critical System
Creators: name: Molina-Vilaplana, Javier
name: Sodano, Pasquale
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In (d+1) dimensional Multiscale Entanglement Renormalization Ansatz (MERA) networks, tensors are connected so as to reproduce the discrete, (d + 2) holographic geometry of Anti de Sitter space (AdSd+2) with the original system lying at the boundary. We analyze the MERA renormalization flow that arises when computing the quantum correlations between two disjoint blocks of a quantum critical system, to show that the structure of the causal cones characteristic of MERA, requires a transition between two different regimes attainable by changing the ratio between the size and the separation of the two disjoint blocks. We argue that this transition in the MERA causal developments of the blocks may be easily accounted by an AdSd+2 black hole geometry when the mutual information is computed using the Ryu-Takayanagi formula. As an explicit example, we use a BTZ AdS3 black hole to compute the MI and the quantum correlations between two disjoint intervals of a one dimensional boundary critical system. Our results for this low dimensional system not only show the existence of a phase transition emerging when the conformal four point ratio reaches a critical value but also provide an intuitive entropic argument accounting for the source of this instability. We discuss the robustness of this transition when finite temperature and finite size effects are taken into account.
description: 21 pages, 5 figures. Abstract and Figure 1 has been modified. Minor modifications in Section 1 and Section 5
DEP Bulletin:Volume 38 Issue 7
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2014

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Radio observations of two binary pulsars
Creators: name: Kasian, Laura Elizabeth
Publisher: name: University of British Columbia
Year: 2012

description: The study of pulsars in binary systems produces a wide variety of scientific results, including unique tests of general relativity and constraints on the equation of state of matter at extremely high densities. Through pulsar timing (which utilizes the fact that pulsars are precise clocks), it is possible to precisely measure the orbital parameters and masses of some binary pulsars, which can place constraints on their mass transfer histories. We present timing results for two binary pulsars. The intermediate-mass binary pulsar (IMBP) PSR J0621+1002 is a mildly recycled pulsar in an 8.3-day orbit around a massive white dwarf (WD) companion. It is one of only two known IMBPs with a precise mass measurement. We collected 9 days' worth of data using the 305-metre Arecibo telescope (allowing for full orbital coverage), which we used to improve constraints on the advance of periastron, and in turn, the pulsar and companion masses (to 1.53^{+0.10}_{-0.20}M☉ and 0.76^{+0.28}_{-0.07} solar masses, respectively) and inclination angle of the system. These results, combined with the relatively long orbital period, suggest a disk accretion evolutionary scenario involving short-lived periods of hyper-accretion, in which a moderate amount of mass has been transferred to the neutron star (NS). PSR J1906+0746 is a young pulsar in a compact ~4-hour orbit around a companion that was discovered in the early stages of the PALFA survey using the 305-metre Arecibo telescope. We present the timing results using data collected between 2005 to 2009 using the Green Bank, Arecibo, and Nançay telescopes. We have measured the advance of periastron, the time dilation and gravitational redshift parameter, and the orbital decay, and we find the pulsar and companion masses to be 1.323^{+0.011}_{-0.011}M☉ and 1.290^{+0.011}_{-0.011} solar masses, respectively. Although the companion may be a second NS, it is more likely to be a massive WD. The system's evolution probably involved a substantial transfer of mass from the WD progenitor onto the NS progenitor through Roche-lobe overflow accretion, followed by the formation of the WD, and a short common envelope phase, and finally the ejection of the envelope and the pulsar-forming supernova.
Measurements of Binary Molecular Diffusion and Dispersion Coefficients of Urea and Ethyl Acetate
Creators: name: Kheirollahi, Shadi
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Dispersion coefficient
subject: Molecular diffusion coefficient
subject: Taylor dispersion method
subject: Engineering--Chemical

description: The environmental impact of in-situ thermal bitumen recovery methods from oil sands has motivated the search for new solvents/chemicals to reduce energy intensity and greenhouse gas emissions. Recently, new solvents/chemicals have been examined on the laboratory and field-scale for co-injection with steam or hot water. However, the fate of the proposed chemicals/solvents in the subsurface has not been studied. Diffusion and dispersion coefficients of the injected chemicals are two important transport properties required to predict the fate of the injected solvents in the subsurface. Ethyl acetate and urea are among the chemicals that have been suggested to improve bitumen recovery from oil sands. However, there is a lack of accurate measurements of the diffusion and dispersion coefficients of these chemicals. To fill this gap, the longitudinal dispersion coefficients of binary liquid mixtures of ethyl acetate and urea were measured using the Taylor dispersion technique at various concentrations of solute and several flow rates by performing a series of displacement experiments through the sand-packed bed. New measurements of the concentration-dependent longitudinal dispersion coefficients in porous media of aqueous urea solution and ethyl acetate-water mixture are reported. In addition, experimental data for the binary diffusion coefficients of ethyl acetate-water systems over the entire range of compositions at temperatures from 298.15 K to 368.15 K are reported.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 14 (19 a)]
Creators: name: Guillielmus De Lomatio
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1282
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Guillielmus de Lomatio, publicus servitor der Stadt Mailand und Notar, überträgt auf Anordnung des Mafeus Mamarella, iudex und assessor des Podestà, dem Marchixius Briottus, syndicus der Stadt Mailand und procurator des Dominikanerkonvents von Mailand, der de sancto Eustorgii genannt wird, ein Stück Land im Gebiet von Galgiana an einem Ort, genannt ad Ronchellam, aus dem Besitz des Philipus Vincemara, der Schuldner des Kapitels ist.
SST/CRISP Observations of Convective Flows in a Sunspot Penumbra
Creators: name: Scharmer, G. B.
name: Henriques, V. M. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. Recent discoveries of intensity correlated downflows in the interior of a sunspot penumbra provide direct evidence for overturning convection, adding to earlier strong indications of convection from filament dynamics observed far from solar disk center, and supporting recent simulations of sunspots. Aims. Using spectropolarimetric observations obtained at a spatial resolution approaching 0'.'1 with the Swedish 1-m Solar Telescope (SST) and its spectropolarimeter CRISP, we investigate whether the convective downflows recently discovered in the C i line at 538.03 nm can also be detected in the wings of the Fe i line at 630.15 nm Methods. We make azimuthal fits of the measured LOS velocities in the core and wings of the 538 nm and 630 nm lines to disentangle the vertical and horizontal flows. To investigate how these depend on the continuum intensity, the azimuthal fits are made separately for each intensity bin. By using spatially high-pass filtered measurements of the LOS component of the magnetic field, the flow properties are determined separately for magnetic spines (relatively strong and vertical field) and inter-spines (weaker and more horizontal field). Results. The dark convective downflows discovered recently in the 538.03 nm line are evident also in the 630.15 nm line, and have similar strength. This convective signature is the same in spines and inter-spines. However, the strong radial (Evershed) outflows are found only in the inter-spines. Conclusions. At the spatial resolution of the present SST/CRISP data, the small-scale intensity pattern seen in continuum images is strongly related to a convective up/down flow pattern that exists everywhere in the penumbra. Earlier failures to detect the dark convective downflows in the interior penumbra can be explained by inadequate spatial resolution in the observed data.
description: Revised and expanded by 2.5 pages. Fig. 14 added
Additional file 1 of Clinical yarning education: development and pilot evaluation of an education program to improve clinical communication in Aboriginal health care - participant, and health manager perspectives
Creators: name: Lin, Ivan
name: Flanagan, Wanda
name: Green, Charmaine
name: Lowell, Anne
name: Coffin, Juli
name: Bessarab, Dawn
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix 1. Retrospective pre/post survey. Appendix 2. Interview/Yarning Guide Departmental and Organisational Representatives
Age-dependent analysis of cerebral structures and arteries in a large database
Creators: name: Mouches, Pauline
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Engineering--Biomedical
subject: Artificial Intelligence

description: Aging of the population is expected to lead to a rapid increase of neurological diseases. Such diseases can progress quickly and detrimentally affect the daily life of patients. Prognosis improves with early diagnosis, but early detection is diffcult. It is crucial to be able to differentiate early stage pathological alteration from normal age-related changes. Thus, there is a need for a better understanding of brain aging and reliable biomarkers. Within that context, the overarching aim of this work is to study normal aging patterns in brain tissues and arteries using a large database of magnetic resonance imaging and angiography data, as well as cardiovascular risk factors from the whole adult life span. To do so, the objectives of this thesis are: (1) to quantify artery morphology variability among adults and identify the impact of age, sex and cardiovascular risk factors on cerebrovascular structures; (2) to combine brain tissue and artery information for biological brain age prediction; (3) to explore the impact of cardiovascular risk factors on the brain age gap, which is a biomarker representing the difference between the biological brain age and chronological age. To achieve these objectives, first, a statistical cerebrovascular atlas is generated from multi-centre adult data. Image analyses and multivariate regression methods are then employed to find associations between brain artery morphology and aging. Second, multi-modal explainable deep learning models are used to accurately estimate the biological brain age and identify predictive brain regions. Third, an exploratory causal analysis is performed to isolate the effects of individual factors on the brain age gap. The results of this work offer a novel insight on brain tissue and artery aging patterns. An in-depth analysis of the brain age gap biomarker is carried out. Novel approaches are proposed to improve brain age prediction models in terms of accuracy and explainability. Finally, innovative methods are used to study cause and effects relationships between brain aging and cardiovascular risk factors. This work aims to uncover clinically relevant findings and represents valuable methodological advancements that could be used in other neuroimaging clinical applications, for instance, to ameliorate predictive models for decision-support.
2008 LC18: a potentially unstable Neptune Trojan
Creators: name: Horner, J.
name: Lykawka, P. S.
name: Bannister, M. T.
name: Francis, P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The recent discovery of the first Neptune Trojan at the planet's trailing (L5) Lagrange point, 2008 LC18, offers an opportunity to confirm the formation mechanism of a member of this important tracer population for the Solar system's dynamical history. We tested the stability of 2008 LC18's orbit through a detailed dynamical study, using test particles spread across the orbital uncertainties in a, e, i and Ω. This showed that the wide uncertainties of the published orbit span regions of both extreme dynamical instability, with lifetimes < 100 Myr, and with significant stability (> 1 Gyr lifetimes). The stability of 2008 LC18's clones is greatly dependent on their semi-major axis and only weakly correlated with their eccentricity. Test particles on orbits with an initial semi-major axis less than 29.91 AU have dynamical half-lives shorter than 100 Myr; in contrast, particles with an initial semi-major axis greater than 29.91 AU exhibit such strong dynamical stability that almost all are retained over the 1 Gyr of our simulations. More observations of this object are necessary to improve the orbit. If 2008 LC18 is in the unstable region, then our simulations imply that it is either a temporary Trojan capture, or a representative of a slowly decaying Trojan population (like its sibling the L4 Neptunian Trojan 2001 QR322), and that it may not be primordial. Alternatively, if the orbit falls into the larger, stable region, then 2008 LC18 is a primordial member of the highly stable and highly inclined component of the Neptune Trojan population, joining 2005 TN53 and 2007 VL305. We attempted to recover 2008 LC18 using the 2.3m telescope at Siding Spring Observatory to provide this astrometry, but were unsuccessful due to the high stellar density of its current sky location near the galactic centre. The recovery of this object will require a telescope in the 8m class.
description: 11 pages, 3 figures, 1 table, accepted for publication in Monthly Notices of the Royal Astronomical Society
Developmental Roadmap of Spermatogonial Stem Cell Metabolic Maturation and Associated Niche Maturation Events
Creators: name: Voigt, Anna Laura
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Male Reproduction
subject: Spermatogonial Stem Cell Maturation
subject: Testis Development
subject: Metabolism
subject: Biology--Molecular
subject: Biology--General
subject: Biology--Cell
subject: Biology--Veterinary Science

description: Spermatogonial Stem Cells (SSCs) are the basis of spermatogenesis and male fertility. SSCs hold a tremendous potential for the treatment of infertility, through the biobanking of testicular tissue and subsequent isolation, expansion in culture, and transplantation of SSCs to replenish spermatogenesis; laboratory techniques that require a profound knowledge of SSC metabolic requirements. While mouse SSC precursors, or primordial germ cells (PGCs), rely on oxidative phosphorylation (OXPHOS), adult human and mouse SSCs mainly use glycolysis to maintain SSC-specific circuits. The metabolic phenotype of prepubertal SSCs and the timeline of metabolic transitions during juvenile development have not been described in any species. Using the pig model, we show that early prepubertal spermatogonia rely on OXPHOS and transition to an adult-like SSC metabolism with 2 months of age, associated with an upregulation of SSC-specific signaling pathways. We delineated a timeline of human SSC metabolic development, from birth to puberty, using single-cell RNA sequencing and deciphered that prepubertal SSCs show a high expression of OXPHOS-related genes until 11 years of age. We further revealed that niche polarization events, visible as tight junction formation between adjacent Sertoli cells, coincide with the maturation of SSC morphology at 11 years that preceded their metabolic transition, and are associated with an accumulation of lipid droplets in Sertoli cells. The accumulation of lipid droplets was conserved between the species. Lipidomic and quantitative (phospho-) proteomic analysis of porcine Sertoli cells revealed a drastic increase of triglycerides (TGs) and decrease of sphingolipids and discovered altered proteins and phosphorylation-sites associated with androgen receptor signaling, cytoskeletal remodeling, and lipid metabolism with maturation, respectively. Together, this work shows that the prepubertal development of SSCs is characterized by distinct metabolic transitions, which require state-specific culture conditions. An accumulation of lipid droplets could indicate Sertoli cell maturational events as critical point in the formation of the SSC niche microenvironment and therefore serve as an indirect tissue-based biomarker for SSC metabolic maturation. This knowledge provides a pivotal piece in understanding the prepubertal development of SSCs and associated niche maturation events that will help to ultimately facilitate their clinical use.
Additional file 2 of The health perceptions, dengue knowledge and control willingness among Dai ethnic minority in Yunnan Province, China
Creators: name: Liu, Hui
name: Fang, Cheng-Jiang
name: Xu, Jian-Wei
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 2.
Customizing Nanoparticles for Environmental Applications - Wastewater Treatment and Valuable Metals Extraction
Creators: name: Nafie, Ghada Hamdy
Publisher: name: Graduate Studies
Year: 2020
Subjects: subject: OSPW
subject: Wastewater treatment
subject: Nanoparticles
subject: Flocculants
subject: Polyacrylamides
subject: Flocculant thickening
subject: Acrylamides
subject: Settling
subject: ISR
subject: CST
subject: Tailing ponds
subject: Suspended particles
subject: Nanopyroxenes
subject: Grafting
subject: Lithium extraction
subject: Lithium production
subject: Brines
subject: Engineering--Chemical
subject: Engineering--Environmental

description: This thesis focuses on two related objectives: the remediation of the environmental footprint of oil sands mining and increasing the efficiency of new energy technologies. Both aim to design and develop nanoparticles for energy and environment applications in order to ensure the sustainability of the global energy resources. Canada produces large volumes of wastewater as a result of mining and other industrial operations. This water contains significant amounts of oil and fines consisting of silt and clays that form a stable colloidal suspension, which presents a challenge to settling. Classical flocculants were proven to be ineffective or costly in the treatment of this water. Tailor-made grafted acrylamide monomer pyroxene nanoparticles (GAM) were prepared and characterized using FTIR, TGA, BET, XRD and SEM. The prepared nanoparticles were then employed as efficient environmentally friendly flocculants for enhanced particle settling. After settling, the turbidity of the supernatant and the capillary suction time of the subnatent were measured. GAM was compared to the commonly used flocculants and were found to enhance particle settling and solid dewaterability. Thus, presenting one material that serves as a practical wastewater treatment solution.The second part of this thesis focuses on the selective recovery of metals present in water sources. Advances in lithium extraction technologies are creating alternative energy possibilities with the goal to exploit the various natural resources, while lowering the carbon and other environmental footprints. However, efficiency and effective extraction remains an ongoing challenge. A lithium titanate nanomaterial was designed and prepared to recover lithium from water sources. Lithium titanate was prepared in the nano range using a hydrothermal method followed by thermal treatment. The material was characterized using XRD, TGA and BET. Experiments were conducted to test the ability of lithium to exit the prepared selective nanostructure. After exposing the nanomaterial to acids for ionic exchange, the supernatant was recovered and tested using an inductively coupled plasma-atomic spectroscopy (ICP). The solids were dried and tested using the XRD to confirm their crystalline structure. This research presents promising applications for the past and future energy market that ensures the sustainability of our natural resources while reducing environmental impacts.
Additional file 1 of Nurse-patient relationship and its implications for retention in the PMTCT of HIV programme in Ghana: an appreciative inquiry
Creators: name: Abraham, Susanna Aba
name: Clow, Sheila E.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1