title: ÐÐ¾Ð½Ð²ÐµÑÐ³ÐµÐ½ÑÐ½ÑÐµ Ð¼ÑÑÐ°ÑÐ¸Ð¸, Ð°ÑÑÐ¾ÑÐ¸Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÑÑ M. tuberculosis
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ° Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 03.04.02 - Ð¤Ð¸Ð·Ð¸ÐºÐ° ; 03.04.02_02 - ÐÐ¸Ð¾ÑÐ¸Ð·Ð¸ÐºÐ°
titleType: Subtitle
Creators: name: ÐÐµÐ±ÐµÐ´ÐµÐ½ÐºÐ¾, ÐÐ»ÑÐ³Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Mycobacterium tuberculosis
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description: Ð­Ð²Ð¾Ð»ÑÑÐ¸Ñ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ M.tuberculosis Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÐµÑ ÑÐµÑÑÐµÐ·Ð½ÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð´Ð»Ñ Ð·Ð´ÑÐ°Ð²Ð¾Ð¾ÑÑÐ°Ð½ÐµÐ½Ð¸Ñ. ÐÐ°ÑÑÐ¾ÑÑÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð¼Ð¿Ð»ÐµÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð¸ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð¿Ð¾Ð»Ð½Ð¾Ð³ÐµÐ½Ð¾Ð¼Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð¸ÑÐºÐ° Ð°ÑÑÐ¾ÑÐ¸Ð°ÑÐ¸Ð¹ - ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐµÑÑÐ° convPhy, ÑÐµÐ»Ñ ÐºÐ¾ÑÐ¾ÑÐ¾Ð³Ð¾ - Ð¸Ð´ÐµÐ½ÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ ÐºÐ¾Ð½Ð²ÐµÑÐ³ÐµÐ½ÑÐ½ÑÑ Ð¼ÑÑÐ°ÑÐ¸Ð¹, Ð¿ÑÐ¾Ð¸Ð·Ð¾ÑÐµÐ´ÑÐ¸Ñ Ð¿Ð¾Ð´ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð° Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ ÑÐ¾ÑÐ¾ÑÐµÐµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ðµ Ñ ÑÐ°Ð½ÐµÐµ Ð¾Ð¿ÑÐ±Ð»Ð¸ÐºÐ¾Ð²Ð°Ð½Ð½ÑÐ¼Ð¸ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸ Ð¿Ð¾ Ð¼Ð°ÑÐºÐµÑÐ°Ð¼ ÑÐµÐ·Ð¸ÑÑÐµÐ½ÑÐ½Ð¾ÑÑÐ¸ Ðº Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½ÑÐ¼ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°Ð¼ Ð´Ð»Ñ Ð¸Ð·Ð¾Ð½Ð¸Ð°Ð·Ð¸Ð´Ð°, ÑÐ¸ÑÐ°Ð¼Ð¿Ð¸ÑÐ¸Ð½Ð° Ð¸ ÑÑÐ°Ð¼Ð±ÑÑÐ¾Ð»Ð° Ð² Ð¸Ð½Ð´Ð¸Ð¹ÑÐºÐ¾Ð¹ Ð¿Ð¾Ð¿ÑÐ»ÑÑÐ¸Ð¸ M. tuberculosis. ÐÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° convPhy Ð¿ÑÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ Ð½Ð¾Ð²ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð¾Ð»Ð½Ð¾Ð³ÐµÐ½Ð¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ 65 Ð²Ð½ÐµÐ»ÐµÐ³Ð¾ÑÐ½ÑÑ Ð¸ 71 Ð»ÐµÐ³Ð¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ñ Ð¸Ð·Ð¾Ð»ÑÑÐ¾Ð², Ð²ÑÑÐ²Ð¸Ð»Ð¾ Ð°ÑÑÐ¾ÑÐ¸Ð°ÑÐ¸Ñ Ð»Ð¾ÐºÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð²Ð¾Ð·Ð±ÑÐ´Ð¸ÑÐµÐ»Ñ Ñ Ð¼ÑÑÐ°ÑÐ¸ÑÐ¼Ð¸ Ð² Ð³ÐµÐ½Ð°Ñ PE/PPE. ÐÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾, Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼ Ð¾Ð±Ð½Ð°ÑÑÐ¶Ð¸Ð» Ð¸Ð½ÑÐµÑÐµÑÐ½ÑÐµ Ð¿Ð°ÑÑÐµÑÐ½Ñ ÐºÐ¾Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐÐÐ (Ð¾Ð´Ð½Ð¾Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð½ÑÑ Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼Ð¾Ð²) Ñ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð², ÑÑÑ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÑ Ðº Ð¸Ð·Ð¾Ð½Ð¸Ð°Ð·Ð¸Ð´Ñ Ð¸ ÑÐ¸ÑÐ°Ð¼Ð¿Ð¸ÑÐ¸Ð½Ñ Ð½Ðµ Ð¾Ð±ÑÑÑÐ½ÑÐµÑÑÑ Ð¸Ð·Ð²ÐµÑÑÐ½ÑÐ¼Ð¸ Ð¼ÑÑÐ°ÑÐ¸ÑÐ¼Ð¸ S315T katG Ð¸ S450L rpoÐ ÐºÐ°Ðº Ð² Ð¸Ð½Ð´Ð¸Ð¹ÑÐºÐ¾Ð¹, ÑÐ°Ðº Ð¸ Ð² ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¿Ð¾Ð¿ÑÐ»ÑÑÐ¸Ð¸.
description: The evolution of drug resistance mechanisms of M. tuberculosis is a global healthcare challenge. The present study contains implementation of genome-wide association study algorithm convPhy based on developing convergence mutations. The test result of developed method shows strong concordance with previously published data. The application of the algorithm convPhy in the analysis of the new data genome sequencing 65 pulmonary and 71 extrapulmonary Russian isolates revealed association of pathogen localization with mutations in the genes of PE/PPE. In addition, the algorithm detected interesting patterns of cooperative SNPs (single-nucleotide polymorphisms) interaction in samples whose resistance to isoniazid and rifampicin is not explained by known mutations of S315T katG and S450L rpoB in both the Indian and Russian populations.