cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ligand-based pharmacophore modelling, structure optimisation, and biological evaluation for the identification of 2-heteroarylthio-N-arylacetamides as novel HSP90 C-terminal inhibitors
Creators: name: Liu, Yajun
name: Li, Chenyao
name: Li, Yajing
name: Zhang, Shuming
name: Zhang, Ning
name: Bian, Xiaobo
name: Tan, Shutao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Virology

description: Targeting Heat shock protein 90 (HSP90) C-terminus is an important strategy to develop HSP90 inhibitors without inducing heat shock response. The development of C-terminal inhibitors, however, is hampered by a lack of understanding regarding the interaction between the HSP90 C-terminus and the present inhibitors. We collected seven classical and structurally diverse HSP90 C-terminal inhibitors and constructed a ligand-based pharmacophore model. The subsequent virtual screening and structural optimisation led to the identification of 2-heteroarylthio-N-arylacetamides as novel HSP90 C-terminal inhibitors. 9 and 27 exhibited strong antitumour activity in vitro by inhibiting proliferation and inducing apoptosis in multiple cancer cell lines. These compounds disrupted the interaction between HSP90 C-terminus and peptidylprolyl isomerase D, exerting a stronger inhibitory effect than novobiocin. 27 significantly induced the degradation of HSP90 clients without triggering heat shock response. In an in vivo study using 4T1 mice breast cancer models, 9 showed a potent antitumour effect without obvious toxicity.
MOESM1 of Steam explosion pretreatment of softwood: the effect of the explosive decompression on enzymatic digestibility
Creators: name: Pielhop, Thomas
name: Amgarten, Janick
name: Rohr, Philipp
name: Studer, Michael
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Computational Biology

description: Additional file 1: Figure S1. Cumulative particle-size distribution of raw biomass and biomass pretreated with and without explosion. Figure S2. Carbohydrate and lignin contents of spruce wood chips after steam pretreatments at different severities with and without explosion. Figure S3. pH of pretreatment liquor after pretreatments at different severities with and without explosion.
Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases
Creators: name: Dudey, Ashley P.
name: Rigby, Jake M.
name: Hughes, Gregory R.
name: Stephenson, G. Richard
name: Storr, Thomas E.
name: Chantry, Andrew
name: Hemmings, Andrew M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 158.3 µM (95% CI = 128.7, 195.1 µM). A structure-activity relationship by synthesis approach aided by molecular docking led to compound 11 which displayed increased potency with an IC50 of 32.7 µM (95% CI = 24.6, 44.3 µM) for WWP1 and 269.2 µM (95% CI = 209.4, 347.9 µM) for WWP2. Molecular docking yielded active site-bound poses suggesting that the heterocyclic imidazo[4,5-b]pyrazine scaffold undertakes a π-stacking interaction with the phenolic group of tyrosine, and the ethyl ester enables strong ion-dipole interactions. Given the therapeutic potential of WWP1 and WWP2, we propose that compound 11 may provide a basis for future lead compound development.
Additional file 1: of Development of the competency scale for primary care managers in Thailand: Scale development
Creators: name: Keerati Kitreerawutiwong
name: Chanaphol Sriruecha
name: Wongsa Laohasiriwong
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The final version of primary care manager competency assessment questionnaire. (DOC 147 kb)
Co-hydrolysis of hydrothermal and dilute acid pretreated populus slurries to support development of a high-throughput pretreatment system
Creators: name: Studer, Michael Hans-Peter
name: Brethauer Studer, Simone
name: DeMartini, Jaclyn D
name: McKenzie, Heather L
name: Wyman, Charles E
Publisher: name: BioMed Central
Year: 2011
Subjects: Xylose
Solid Concentration
Sugar Yield
Glucose Yield
Enzyme Loading

description: Background The BioEnergy Science Center (BESC) developed a high-throughput screening method to rapidly identify low-recalcitrance biomass variants. Because the customary separation and analysis of liquid and solids between pretreatment and enzymatic hydrolysis used in conventional analyses is slow, labor-intensive and very difficult to automate, a streamlined approach we term 'co-hydrolysis' was developed. In this method, the solids and liquid in the pretreated biomass slurry are not separated, but instead hydrolysis is performed by adding enzymes to the whole pretreated slurry. The effects of pretreatment method, severity and solids loading on co-hydrolysis performance were investigated. Results For hydrothermal pretreatment at solids concentrations of 0.5 to 2%, high enzyme protein loadings of about 100 mg/g of substrate (glucan plus xylan) in the original poplar wood achieved glucose and xylose yields for co-hydrolysis that were comparable with those for washed solids. In addition, although poplar wood sugar yields from co-hydrolysis at 2% solids concentrations fell short of those from hydrolysis of washed solids after dilute sulfuric acid pretreatment even at high enzyme loadings, pretreatment at 0.5% solids concentrations resulted in similar yields for all but the lowest enzyme loading. Conclusions Overall, the influence of severity on susceptibility of pretreated substrates to enzymatic hydrolysis was clearly discernable, showing co-hydrolysis to be a viable approach for identifying plant-pretreatment-enzyme combinations with substantial advantages for sugar production.
Guide des conceptions communales des installations sportives
Creators: name: Wyder, Rita
name: Bosshart, Fritz
name: Gilgen, Kurt
name: Beugger, Thomas
name: Schaffer, Roland
name: Rey, Walter
name: Von Kaenel, Jean-Pierre
name: Held, Mathias
Publisher: name: Bundesamt für Sport BASPO
Year: 2007
Subjects: Infrastructure sportive Construction Planification Commune Sport Installations sportives

description: Le guide des conceptions communales des installations sportives fournit des informations de base à ce sujet, il indique comment élaborer une conception étape par étape et contient des modèles de questionnaires pour évaluer les besoins des différentes catégories d’utilisateurs.
Development of a long span self-supporting compact façade system for industrial buildings
Creators: name: Hausammann, Roman
name: Franke, Steffen
name: Schiere, Marcus Jacob
name: Giordano, Nicolàs
Year: 2016
Subjects: Wood-based materials Compact façade element Hall construction Structural response sandwich panel

description: Common compact façade elements are usually not self-supporting over a span of more than 5 m. For hall buildings self-supporting façade systems are essential to avoid an additional secondary load-bearing structure. PUR sandwich panels, fiber cement boards or aerated concrete elements are widely used. Façade systems made out of timber components or wooden materials are often used for residential or office buildings in Switzerland or other European countries. A wood-based compact façade system doesn’t exist. The innovative approach is to combine weather-resisting particleboards as inner and outer layer with a core insulation made by soft wood fiber or cork board. The core insulation and the composite behavior were investigated in order to fulfill the physical and static requirements of three different scenarios (production halls, warehouses and sports halls).
(Keine) Zeit für Elternbildung?!
Creators: name: Chiapparini, Emanuela
Year: 2022

description: Im Vortag werden aktuelle Befunde aus der Studie «Elternbildungssettings und Erreichbarkeit von Eltern» (2021) vorgestellt und auf Bedürfnisse und Interessen von Eltern hingewiesen. Ziel ist es, Impulse für die katechetische Praxis zu erhalten und einzelne Aspekte der Studie für die katechetische Praxis vertiefen.
Additional file 3: of Translating knowledge for action against stroke â   using 5-minute videos for stroke survivors and caregivers to improve post-stroke outcomes: study protocol for a randomized controlled trial (Movies4Stroke)
Creators: name: Ayeesha Kamal
name: Adeel Khoja
name: Usmani, Bushra
name: Muqeet, Abdul
name: Fabiha Zaidi
name: Ahmed, Masood
name: Shakeel, Saadia
name: Soomro, Nabila
name: Ambreen Gowani
name: Asad, Nargis
name: Ahmed, Asma
name: Sayani, Saleem
name: Azam, Iqbal
name: Saleem, Sarah
Publisher: name: Figshare
Year: 2016
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Participant timeline. (DOCX 48 kb)
Amanita (sect. Lepidella) Corner & Bas
Creators: name: Liu, Yuan S.
name: Kumla, Jaturong
name: Suwannarach, Nakarin
name: Sysouphanthong, Phongeun
name: Lumyong, Saisamorn
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Fungi
Basidiomycota
Agaricomycetes
Agaricales
Amanitaceae
Amanita

description: Key to the Thai species of Amanita sect. Lepidella
1. Basidioma large; pileus golden yellow covering with fibrillose to floccoso or somewhat pulverulent, vivid yellow volval remnants; clamps absent; ......................................................................................................................................................... A. aureofloccosa
1. Basidioma small to very large; pileus white or pale tawny brown covering with fibrillose white scales or floccoso-verrucose to felty squamules; clamps present; .......................................................................................................................................................2
2. Basidioma small to medium-size, pileus white to yellowish white; Annulus superior; basidiospores broadly ellipsoid to ellipsoid; ...................................................................................................................................................................................... A. albicarnosa
2. Basidioma large to very large, pileus yellowish brown to pale tawny brown; Annulus apical to subapical; basidiospores subglobose; ..................................................................................................................................................................... A. manicata
description: Published as part of Liu, Yuan S., Kumla, Jaturong, Suwannarach, Nakarin, Sysouphanthong, Phongeun & Lumyong, Saisamorn, 2022, Three species of Amanita section Lepidella (Amanitaceae, Agaricales) from northern Thailand, pp. 16-28 in Phytotaxa 570 (1) on page 25, DOI: 10.11646/phytotaxa.570.1.2, http://zenodo.org/record/7529863
New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies
Creators: name: Mohamed, Asmaa H.
name: Alshammari, Mohammed B.
name: Aly, Ashraf A.
name: Sadek, Kamal U.
name: Ahmad, Akil
name: Aziz, Eman A.
name: El-Yazbi, Amira F.
name: El-Agroudy, Eman J.
name: Abdelaziz, Marwa E.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: In this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one gave a hybrid scaffold that integrated key structural elements essential for DNA damage via direct DNA intercalation and inhibition of the topoisomerase II enzyme. All the synthesized compounds were screened to detect their DNA damage using a terbium fluorescent probe. Results demonstrated that 4-phenyl-imidazoles 5b and 5e in addition to 4-(4-chlorophenyl)imidazoles 5h and 5j would induce detectable potent damage in ctDNA. The four most potent compounds as DNA intercalators were further evaluated for their antiproliferative activity against HepG2, MCF-7 and HCT-116 utilizing the MTT assay. The highest anticancer activity was recorded with compounds 5b and 5h against the breast cancer cell line MCF-7 which were 1.5- and 3- folds more active than doxorubicin, respectively. Therefore, imidazole-2-thione tethered acenaphthylenone derivatives can be considered as promising scaffold for the development of effective dual DNA intercalators and topoisomerase II inhibitors.
Development of a stand-alone vibration measurement system for bridge monitoring
Creators: name: Lins, Dio Hans
name: Franke, Steffen
name: Weber, Roger
name: Franke, Bettina
name: Karolin, Joel
Publisher: name: World Conference on Timber Engineering (WCTE 2023)
Year: 2023

description: The quality assurance of timber bridges is currently ensured mainly manually by regular visual inspections over the entire life cycle. To reduce this (cost) effort, the possibility of continuously recording the condition of bridges through monitoring is being investigated. This would also increase the confidence in the long-term load-bearing capacity of timber bridges among planners and public. In addition to the permanent recording of the wood moisture content, conclusions can also be drawn about the condition and even possible damage by recording the natural frequencies which depends on the stiffness. For this purpose, a stand-alone vibration measurement and evaluation system was developed, which is easy to handle and suitable for long-term monitoring due to its energy efficiency. Beside a first application on a low-traffic timber bridge for several months, the system was validated with investigations on various types of artificial damages on the natural frequency of timber components.
Additional file 2: Table S2. of Transplantation of hESC-derived hepatocytes protects mice from liver injury
Creators: name: Tolosa, Laia
name: Caron, Jérôme
name: Hannoun, Zara
name: Antoni, Marc
name: López, Silvia
name: Burks, Deborah
name: Castell, Jose
name: Weber, Anne
name: Maria-Jose Gomez-Lechon
name: Dubart-Kupperschmitt, Anne
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Primers used for RT-PCR of Human mRNAs. (PDF 79.6 KB)
Artemia Leach 1819
Creators: name: Padhye, Sameer M.
name: Lazo-Wasem, Eric A.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Anostraca
Artemiidae
Artemia

description: Artemia sp.
Fig. 1 (A–H)
Material examined. YPM IZ 003582.CR: Five males and 3 females (for eggs); eggs from 2 females used for SEM images
Locality. Tso Kar [salt lake], Indian Tibet (per Bond, 1934). Original label date: 0 5 Sep 1932 (Ladakh, Jammu & Kashmir, India).
Comments. For general description refer to Bond (1934:32). The second antennal frontal knob is semicircular in shape (Fig.1A–C), nearly 0.3x the size of the antennal width (at point of attachment) (Fig.1B & C). Frontal knob microspinulae mostly paired, less frequently in triplets, rarely as single spines. These spinulae more densely covered the middle and lower surfaces, and were themselves stout, gently tapering to the apex (Fig.1D).
The gonopod bears a distinct spine like projection proximally (Fig.1E & F), that is nearly 0.25 x the width of the gonopod base (Fig.1G); the spine apex is ornamented with smaller spines. The everted gonopod was not observed (Fig.1H).
All cercopod setae are broken, and not properly observable.
The egg diameter ranged 176–195 µm, and bore no surface ornamentation (typical for the genus).
Absence of a gonopod basal spine is a characteristic trait of both A. salina (Linneaus, 1758) as well as A. tibetiana Abatzopoulos, Zhang & Sorgeloos, 1998 (Mura & Brecciaroli 2004; Rogers, 2017 in press). A basal spine was clearly observed in all male specimens (Fig.1E & F) which indicates that the Yale specimens are not assignable to either A. tibetiana or A. salina. Artemia sinica Cai, 1989, described from China, does have a basal spine (sensu Rogers et al., 2017 in press). The armature at the basal spine apex of the studied population also grossly resembled to that of A. sinica described by Mura & Brecciaroli (2004) as well as the microspinulae number and its frequency (as per Rogers in press). Given that A. sinica is reported from an adjacent region and considering the speculation that Tso Kar population might have been introduced by caravans carrying salt in the region [as per Bond (1934), this species could be considered as A. sinica. This species is reported to have ten or more setae on its cercopods (sensu Rogers et al., 2017 in press) which could not be observed due to damage, however, as per the illustrations depicted by Bond (1934), this number is less than eight. We have not studied the types of A. sinica. Therefore, until confirmatory investigations are carried out, we refer to this species as Artemia sp. only.
description: Published as part of Padhye, Sameer M. & Lazo-Wasem, Eric A., 2018, An updated and detailed taxonomical account of the large Branchiopoda (Crustacea: Branchiopoda: Anostraca, Notostraca, Spinicaudata) from the Yale North India Expedition deposited in the Yale Peabody Natural History Museum, pp. 207-218 in Zootaxa 4394 (2) on pages 208-209, DOI: 10.11646/zootaxa.4394.2.3, http://zenodo.org/record/1197652
E-LKW - Lebensdauerverlängerung statt Elektroschrott
Creators: name: Jost, Monika
name: Affolter, Peter
Publisher: name: Berner Fachhochschule BFH, Architektur, Holz und Bau/Technik und Informatik
Year: 2022

description: Die Berner Fachhochschule BFH hat im Frühjahr 2021 von Lidl Schweiz zwei Elektro-LKW der ersten Generation zu Forschungszwecken erhalten. Normalerweise hätten die LKW verschrottet werden müssen, da die Batterien altersschwach waren und der Aufwand eines Retrofits, wie es die BFH nun ausgeführt hat, unter rein ökonomischen Gesichtspunkten nicht sinnvoll gewesen wäre.
Additional file 2: of Initial peptidomic profiling of Brazilian sea urchins: Arbacia lixula, Lytechinus variegatus and Echinometra lucunter
Creators: name: Sciani, Juliana
name: Andrews Emerenciano
name: Silva, José Cunha Da
name: Pimenta, Daniel
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Alignment of peptides obtained from E. lucunter, L. variegatus and A. lixula with the peptides described from other sea urchin species. (DOCX 18 kb)
Additional file 1: Table S1. of Efficacy of limb salvage with primary tumor resection simultaneously for solitary bone metastasis in limbs
Creators: name: Cheng, Dong-Dong
name: Jie-Lai Yang
name: Hu, Tu
name: Yang, Qing-Cheng
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additonal information of 20 patients. (DOCX 18Â kb)
Additional file 6: of Translating knowledge for action against stroke â   using 5-minute videos for stroke survivors and caregivers to improve post-stroke outcomes: study protocol for a randomized controlled trial (Movies4Stroke)
Creators: name: Ayeesha Kamal
name: Adeel Khoja
name: Usmani, Bushra
name: Muqeet, Abdul
name: Fabiha Zaidi
name: Ahmed, Masood
name: Shakeel, Saadia
name: Soomro, Nabila
name: Ambreen Gowani
name: Asad, Nargis
name: Ahmed, Asma
name: Sayani, Saleem
name: Azam, Iqbal
name: Saleem, Sarah
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: SPIRIT checklist. (DOC 122 kb)
Additional file 7: of Translating knowledge for action against stroke â   using 5-minute videos for stroke survivors and caregivers to improve post-stroke outcomes: study protocol for a randomized controlled trial (Movies4Stroke)
Creators: name: Ayeesha Kamal
name: Adeel Khoja
name: Usmani, Bushra
name: Muqeet, Abdul
name: Fabiha Zaidi
name: Ahmed, Masood
name: Shakeel, Saadia
name: Soomro, Nabila
name: Ambreen Gowani
name: Asad, Nargis
name: Ahmed, Asma
name: Sayani, Saleem
name: Azam, Iqbal
name: Saleem, Sarah
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: Review of previous studies. (DOCX 31 kb)
Avithrips Ulitzka, 2024, gen. n.
Creators: name: Ulitzka, Manfred R.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Thysanoptera
Melanthripidae
Avithrips

description: Avithrips gen. n.
Type species. Avithrips yellae gen. et sp. n.
Diagnosis. Head with mouth cone exceptionally long, reaching back to the base of abdomen. Antennae nine-segmented with the distal segments fully distinct from each other; segments I–III distinctly stronger than distal segments; III distally with a structure interpreted as a transverse sensorium (sensoria not visible on IV). Setae on head and pronotum not assessable; one longer seta visible at the hind margin of pronotum. Fore wings with broadly rounded tips; front margin without wing fringes; longitudinal veins complete; with cross veins. Wing surface covered with microtrichia. Fore femora slender; fore tarsus without hamus. Abdominal segment VIII with ovipositor curved upwards.
Based on the above-mentioned character states of the fore wings and the shape of the ovipositor Avithrips gen. n. is attributed to Melanthripidae (see Bhatti 2006), even though some of the plesiomorphic features present in members of this thysanopteran family are not visible on the holotype due its lateral position in the amber matrix. Regarding the antennae, the basal segments of Avithrips gen. n. are stronger than usual in Melanthripidae. The shape of the structure on segment III, which is interpreted as a distal antennal sensorium, however, would support the here proposed classification.
With its long mouth cone Avithrips gen. n. resembles Proboscisthrips mammuthoides Ulitzka from Baltic Eocene amber. However, the latter has the major setae on abdominal tergites IX and X much stronger. Moreover, the abdominal segment IX of P. mammuthoides is longer and covered with dense rows of microtrichia (Ulitzka 2017). Most cephalic and pronotal setae of Avithrips gen. n. are not assessable and at least the head setae might be short. Regarding this feature, Avithrips gen. n. differs from most members of Melanthripidae, except for some species like Cranothrips bellisi Mound & Marullo (see Pereyra & Mound 2009). Compared to those, however, the antennae of Avithrips gen. n. are different.
Etymology. The name of the new genus comes from the Latin word avis, meaning ‘bird’ and -thrips, the usual term for a genus within Thysanoptera. It refers to the long and bird-beak-like mouth cone of the type species.
description: Published as part of Ulitzka, Manfred R., 2024, Late Cretaceous thrips (Thysanoptera) from Hti Lin amber, pp. 99-106 in Zootaxa 5489 (1) on page 101, DOI: 10.11646/zootaxa.5489.1.6, http://zenodo.org/record/13211257
MOESM4 of Paleomagnetic inclination variations during the last 200Â kyr in the Okhotsk Sea and their relation to persistent non-axial-dipole field
Creators: name: Toshitsugu Yamazaki
name: Shimono, Takaya
name: Inoue, Seiko
Publisher: name: Figshare
Year: 2016
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 4. Inter-core correlation between Sites GC1Â +Â PC7 and GC11. (a) Correlation and age estimation using magnetic susceptibility, (b) comparison of relative paleointensity records after the correlation, and (c) corresponding inclination records.
MOESM1 of Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia
Creators: name: Adriaens, Michiel
name: Prickaerts, Peggy
name: Chan-Seng-Yue, Michelle
name: Beucken, Twan Den
name: Dahlmans, Vivian
name: Eijssen, Lars
name: Beck, Timothy
name: Wouters, Bradly
name: Voncken, Jan
name: Evelo, Chris
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 1: Figure S1. (Top) H3K4me3 peak intensity density distribution proximal to the TSS in relation to oxygen deprivation and reoxygenation. (Bottom) H3K27me3-distribution proximal to the TSS in relation to oxygen deprivation and reoxygenation. Legend: t=0: normoxia; t=8: 8 hours of hypoxia; t=24: 24 hours of hypoxia; t=+8: 8 hours of subsequent reoxygenation. These figures and underlying data have also been published in an accompanying paper [10]. Figure S2. Relation between the ratio of H3K4me3 and H3K27me3 enrichment at the transcription start site for each gene with its associated expression level at 0 hours of hypoxia (i.e. t=0, normoxia). Higher enrichment is associated with higher expression, as observed previously [46].
Additional file 5: Table S1. of Chromosome3D: reconstructing three-dimensional chromosomal structures from Hi-C interaction frequency data using distance geometry simulated annealing
Creators: name: Adhikari, Badri
name: Trieu, Tuan
name: Jianlin Cheng
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Spearmanâ  s rank correlation coefficient between distances obtained from reconstructed structures and input IFs computed after filtering 0.1Â L short-range values; the numbers in parenthesis are the SRCC values for extended models used for comparison. The last two columns report the execution time in hours and minutes. (DOCX 22Â kb)
Streptocephalus longimanus Bond 1934
Creators: name: Padhye, Sameer M.
name: Lazo-Wasem, Eric A.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Anostraca
Streptocephalidae
Streptocephalus
Streptocephalus longimanus

description: Streptocephalus longimanus Bond, 1934
Fig.2 (A & B)
Material examined. YPM IZ 003590.CR: Eggs from the female allotype.
Locality. Madras Presidency, Mahabalipuram [as per Bond (1934)] (Mahabalipuram, Tamil Nadu, India). Original label data: India, Punjab, Rawalpindi District, Sohara G. E. Hutchinson, coll. 3-III-1932 (Sohara, Rawalpindi District, Pakistan).
Comments. Adult morphology matches that of the descriptions of Bond (1934) and Velu and Munuswamy (2005). Eggs 202 µm and 208 µm (n=2), with large regular polygons, each polygon with 4–6 angles (Fig.2A). Polygon number = 12 and 13; wh: dw ratio =0.3–0.5. Polygonal walls broadly triangular, upper edges of the walls distinct. Floors of the polygons nearly flat with faint dimples (Fig. 2B). The eggs, when compared with other Indian streptocephalids, are characteristically unique with fewer well-defined polygons with thicker and shorter triangular walls (for more details of egg morphology of other Indian streptocephalids, refer to Velu & Munuswamy (2005) and Padhye et al., (2016)). The polygonal walls of the eggs from the Yale allotype show a different morphology from the eggs reported by Velu & Munuswamy (2005) with the former having more triangular and relatively thinner walls. The polygon number also seemed to be fewer in the allotype but showed a similar surface of the polygonal base. It has been documented that egg surface morphology varies between different populations of the same species and sometimes even between females of same population in Indian streptocephalids (Padhye et al., 2016) and hence is not taxonomically informative by itself. This structure thus represents one more egg surface ornamentation pattern in S. longimanus.
description: Published as part of Padhye, Sameer M. & Lazo-Wasem, Eric A., 2018, An updated and detailed taxonomical account of the large Branchiopoda (Crustacea: Branchiopoda: Anostraca, Notostraca, Spinicaudata) from the Yale North India Expedition deposited in the Yale Peabody Natural History Museum, pp. 207-218 in Zootaxa 4394 (2) on page 209, DOI: 10.11646/zootaxa.4394.2.3, http://zenodo.org/record/1197652
Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis
Creators: name: Singh, Manisha
name: Batt, Sarah M.
name: Canales, Christian S. C.
name: Pavan, Fernando R.
name: Kumar, Sethu Arun
name: Akshatha, Handattu S.
name: Bhagyalalitha, Meduri
name: Pujar, Karthik G.
name: Bidye, Durgesh
name: Pujar, Gurubasavaraj V.
name: Besra, Gurdyal S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology

description: Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2′-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberculosis, Mycobacterium tuberculosis. In this study, we designed, synthesised, and evaluated 15 (BOK-1–BOK-10 and BOP-1–BOP-5) potential inhibitors of DprE1 from a series of 1,2,3-triazole ligands using a validated DprE1 inhibition assay. Two compounds, BOK-2 and BOK-3, demonstrated significant inhibition with IC50 values of 2.2 ± 0.1 and 3.0 ± 0.6 μM, respectively, whereas the standard drug (TCA-1) showed inhibition at 3.0 ± 0.2 μM. Through molecular modelling and dynamic simulations, we explored the structural relationships between selected 1,2,3-triazole compounds and DprE1, revealing key features for effective drug–target interactions. This study introduces a novel approach for designing ligands against DprE1, offering a potential therapeutic strategy for tuberculosis treatment. Identification of 15 (BOK-1–BOK-10 and BOP-1–BOP-5) potent inhibitors of DprE1 enzyme from 1,2,3-triazole ligands.BOK-2 and BOK-3 exhibited significant DprE1 inhibition with IC50 values of 2.2 ± 0.1 and 3.0 ± 0.6 μM, respectively.Molecular modelling and dynamic simulations elucidated key structural features for effective drug–target interactions.Novel approach introduced for designing DprE1 ligands, potentially aiding tuberculosis treatment.Findings offer promising candidates for future tuberculosis research. Identification of 15 (BOK-1–BOK-10 and BOP-1–BOP-5) potent inhibitors of DprE1 enzyme from 1,2,3-triazole ligands. BOK-2 and BOK-3 exhibited significant DprE1 inhibition with IC50 values of 2.2 ± 0.1 and 3.0 ± 0.6 μM, respectively. Molecular modelling and dynamic simulations elucidated key structural features for effective drug–target interactions. Novel approach introduced for designing DprE1 ligands, potentially aiding tuberculosis treatment. Findings offer promising candidates for future tuberculosis research.
Unterrichtsentwicklung im Sportunterricht mit qims.ch
Creators: name: Ulrich, Wolfgang
name: Stillhart, Mischa
Publisher: name: Hofmann
Year: 2013
Subjects: Evaluation Qualitative Analyse Lehrerverhalten Didaktik Unterrichtsgestaltung Messverfahren Schulsport Sportpädagogik Sportunterricht Anforderungsprofil Beurteilung

description: Bislang standen Sportlehrpersonen nur wenige Instrumente zur Betrachtung des Unterrichts zur Verfügung, welche der Spezifität des Faches Rechnung tragen. Mit einer Qualitätsbetrachtung, die ausgehend von den Bedürfnissen der Sportlehrpersonen entwickelt wurde und sich an einem Kreislaufmodell orientiert, bietet qims.ch nun fachspezifische Unterstützung an. Was guter Sportunterricht ist, wird über klar formulierte Qualitätskriterien definiert und für die Datenerhebung stehen rund 40 praxiserprobte Feedback- und Messinstrumente zur Verfügung, welche eine differenzierte Evaluation ermöglichen. Die Grundlage für die fachspezifische Unterrichtsentwicklung im Fach Sport ist damit gelegt.
Triops cancriformis Bosc
Creators: name: Padhye, Sameer M.
name: Lazo-Wasem, Eric A.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Notostraca
Triopsidae
Triops
Triops cancriformis

description: Triops cancriformis (Bosc)
Fig.3 (A–D)
Material examined. YPM IZ 003588.CR: Single female
Locality. Punjab, Sargodhar District, 3 mi. South of Nuriwala, 6-III-1932 (as per Bond (1934). Note in catalog: “c. 305 m [eters].”(Sargodha District, Punjab, Pakistan)
Diagnosis. Length of the carapace: 1.24 cm (from tip of carapace to terminal carinal spine); Total length: 2.56 cm (from tip of carapace to tip of telson); Body segments: Thirty three with 18 abdominal segments; Dorsal organ: Similar to Kashmir population (circular) (Fig.3B)
Carapace oval with about 50 sulcus spines; terminal spine distinct, about 1.1 times longer than the adjacent sulcus spines (Fig.3A).
Tenth trunk limb endital spines. Damaged, spines could not be counted.
Apodal segments. 4.25 segments; supernumeraries absent on the ventral side.
Telson. A single large medial spine with many (~26) small spines (~0.1 or even less times the medial spines in length) scattered anteriorly to it; two furcal spines present on each side; two large posterior marginal spines present with one smaller spine present on the right-hand side adjacent to the large spine; telson length ratio of 0.32; cercopods broken (Fig.3C & D)
Comments. The specimen from the collection has similar characters as compared to the Kashmir population (Padhye & Ghate, 2015) except in the bigger size of the specimen. Also, the collection site is close to the earlier studied population (Kashmir). Given that there was only a single specimen, detailed comparison at this stage would not be informative. Hence, with the available information, we refer this specimen as a representative of a nongonochoric population of T. cancriformis.
description: Published as part of Padhye, Sameer M. & Lazo-Wasem, Eric A., 2018, An updated and detailed taxonomical account of the large Branchiopoda (Crustacea: Branchiopoda: Anostraca, Notostraca, Spinicaudata) from the Yale North India Expedition deposited in the Yale Peabody Natural History Museum, pp. 207-218 in Zootaxa 4394 (2) on page 211, DOI: 10.11646/zootaxa.4394.2.3, http://zenodo.org/record/1197652
MOESM3 of A Bayesian inference method for the analysis of transcriptional regulatory networks in metagenomic data
Creators: name: Hobbs, Elizabeth
name: Talmo Pereira
name: O’Neill, Patrick
name: Erill, Ivan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Distribution of eggNOG/COG posterior probabilities as a function of the number of promoter sequences mapping to the eggNOG/COG after adjusting for sensitivity with θ = 6.65. The x-axis indicates eggNOG/COG rank number, sorted by decreasing posterior probability. Bubble size indicates the number of promoters mapping to a given eggNOG/COG.
Design, synthesis, and biological activity evaluation of dihydromyricetin derivatives against SARS-CoV-2-Omicron virus
Creators: name: Wu, Cong
name: Jiang, Qi
name: Zhong, Hui
name: Zhou, Xudong
name: Liu, Leping
name: Pan, Tong
name: Liu, Chao
name: Wang, Wei
name: Sheng, Wenbing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: An oxidising and substituting one-pot reaction strategy has been developed to synthesise dihydromyricetin derivatives with the aim of enhancing the inhibitory activity of dihydromyricetin against SARS-CoV-2. Different ω-methoxy-ω-oxeylkyl was introduced in C7-OH site and yielded eight analogs, all of them showed good inhibitory activity against SARS-CoV-2 3CLpro with IC50 values ranging from 0.72 to 2.36 μM. In the Vero E6-cell, compound 3 has a good activity of anti-SARS-CoV-2 virus (Omicron virus BA.5) in the prevention model, with an EC50 of 15.84 μM, and so do compound 10 in the therapeutic model, with an EC50 of 11.52 μM. The results suggest that the introduction of long chain ω-oxeylkyl at C7-OH facilitate the inhibition of viral replication in the therapeutic model, which is consistent with the binding energies predicted from molecular docking conclusions. It implies that dihydromyricetin derivatives have the potential to become effective inhibitors of SARS-CoV-2 Omicron and other viruses.
Isolepis fluitans R. Br.
Creators: name: Info Flora
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Isolepis
Isolepis fluitans

description: Isolepis fluitans (L.) R. Br.
Art ISFS: 216250 Checklist: 1024760 Cyperaceae Isolepis Isolepis fluitans (L.) R. Br.
ZusammenfassungKEINE ANGABE
Ökologie
Lebensraum Lebensraumnach Delarze & al. 2015
KEINE ANGABE
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Nomenklatur
Gültiger Name (Checklist 2017):Isolepis fluitans(L.) R. Br.
Volksname
Deutscher Name: -- Nom français: -- Nome italiano: --
Übereinstimmung mit anderen Referenzwerken
RelationNomReferenzwerkeNo=Isolepis fluitans (L.) R. Br.Checklist 2017216250
= Taxon stimmt mit akzeptiertem Taxon überein (Checklist 2017)  Taxon enthält (neben anderen) auch das akzeptierte Taxon (Checklist 2017)
Kommentare aus der Checklist 2017 Neu aufgenommenes Taxon für das grenznahe Ausland. Checklist
Status Indigenat: -
Liste der gefährdeten Pflanzen IUCN(nach Walter & Gillett 1997): Nein
description: Published as part of Info Flora, 2021,
MOESM1 of “Gap hunting” to characterize clustered probe signals in Illumina methylation array data
Creators: name: Andrews, Shan
name: Ladd-Acosta, Christine
name: Feinberg, Andrew
name: Hansen, Kasper
name: M. Fallin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Figure S1. Number of gap signals detected in SEED at various combinations of the “threshold” and “outCutoff” arguments to gaphunter().
MOESM4 of Does the gender composition of forest and fishery management groups affect resource governance and conservation outcomes? A systematic map
Creators: name: Leisher, Craig
name: Gheda Temsah
name: Booker, Francesca
name: Day, Michael
name: Samberg, Leah
name: Prosnitz, Debra
name: Agarwal, Bina
name: Matthews, Elizabeth
name: Roe, Dilys
name: Russell, Diane
name: Sunderland, Terry
name: Wilkie, David
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Additional file 4. Key findings from included studies.
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Creators: name: Li, Keting
name: Hu, Wenshu
name: Wang, Yingjie
name: Chen, Wenxing
name: Wen, Hongmei
name: Liu, Jian
name: Li, Wei
name: Wang, Bo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Disruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far. Drug repurposing is a validated, practical approach to drug discovery. In this regard, we employed structure-based virtual screening in a reservoir of marketed drugs and identified nintedanib as a new MDM2/MDMX dual inhibitor. The computational structure analysis and biochemical experiments uncover that nintedanib binds MDM2/MDMX similarly to RO2443, a dual MDM2/MDMX inhibitor. Furthermore, the mechanistic study reveals that nintedanib disrupts the physical interaction of p53-MDM2/MDMX, enabling the transcriptional activation of p53 and the subsequent cell cycle arrest and growth inhibition in p53+/+ cancer cells. Lastly, structural minimisation of nintedanib yields H3 with the equivalent potency. In summary, this work provides a solid foundation for reshaping nintedanib as a valuable lead compound for the further design of MDM2/MDMX dual inhibitors.
Das Patientendossier (in der Schweiz)
Creators: name: Bürkle, Thomas
Year: 2022

description: Das Patientendossier (in der Schweiz) Die Schweiz hat bereits 2007 begonnen, eine eHealth Strategie herauszugeben, bei der ein besserer Datenaustausch zwischen Spitälern, niedergelassenen Ärzten, anderen Gesundheitsversorgern und dem Patienten selbst im Mittelpunkt stand. Rasch hat sich ein sogenanntes „Elektronisches Patientendossier“ (EPD als ein zentrales Element dieser Strategie herauskristallisiert. 2015 wurden mit dem EPD-Gesetz die notwendigen Grundlagen gelegt und parallel die technischen Rahmenbedingungen definiert. Das Schweizer EPD basiert auf den IHE Profilen aus der IT Infrastructure Domain (ITI) und ist dezentral organisiert. Geplant war die Bereitstellung zum 15.4.2020, aufgrund der notwendigen Zertifizierung der sogenannten Stammgemeinschaften verzögerte sich der Prozess, aber am 14.12.2020 konnte bei der Stammgemeinschaft emedo im Aargau das erste EPD eröffnet werden. Mittlerweile sind 7 Stammgemeinschaften zertifiziert und ein EPD kann bereits in diversen Kantonen eröffnet werden. Der Vortrag wird eine Übersicht über die Entwicklung des Schweizer EPD, dessen Aufbau und Infrastruktur, verwendete Techniken und den aktuellen Stand und anstehende Entwicklungen vermitteln.
MOESM5 of “Gap hunting” to characterize clustered probe signals in Illumina methylation array data
Creators: name: Andrews, Shan
name: Ladd-Acosta, Christine
name: Feinberg, Andrew
name: Hansen, Kasper
name: M. Fallin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5: Figures S3–S25. All Remaining C and G site scenarios for Type II and Type I probes. Each additional scenario of a C and G site-mapping SNP delimited in Fig. 2 not including the scenario show in Fig. 3. Each of these figures contains the same panels (a–d) as seen in Fig. 3. All scenarios demonstrate the expected behavior shown in Fig. 2.