cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Electron Waiting Times in Mesoscopic Conductors
Creators: name: Albert, Mathias
name: Haack, Géraldine
name: Flindt, Christian
name: Büttiker, Markus
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Electron transport in mesoscopic conductors has traditionally involved investigations of the mean current and the fluctuations of the current. A complementary view on charge transport is provided by the distribution of waiting times between charge carriers, but a proper theoretical framework for coherent electronic systems has so far been lacking. Here we develop a quantum theory of electron waiting times in mesoscopic conductors expressed by a compact determinant formula. We illustrate our methodology by calculating the waiting time distribution for a quantum point contact and find a cross-over from Wigner-Dyson statistics at full transmission to Poisson statistics close to pinch-off. Even when the low-frequency transport is noiseless, the electrons are not equally spaced in time due to their inherent wave nature. We discuss the implications for renewal theory in mesoscopic systems and point out several analogies with energy level statistics and random matrix theory.
description: 4+ pages, 3 figures
National Association of Women Artists 67th Annual Exhibition, May 7 - May 24th, 1959
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1959

description: The National Association of Women Artists (NAWA) was established in 1889 and is the oldest professional women's fine arts organization in the United States. NAWA's mission is to promote awareness of, and interest in, visual art created by women in the United States. As part of this effort NAWA holds an annual exhibition of works by members of the association and publishes an exhibition catalog to accompany or commemorate the annual exhibitions. These catalogs not only function as an exhibition catalog, but also as a document that summarizes the structure, membership, and activities of the association.Information that can be found in these catalogs includes lists of officers, members of the executive board and committees, prize winners, lists of exhibitor and members, and images of some of the artwork exhibited. Catalogs from the 2000s also include information on NAWA events and activities beyond the annual exhibition.Please note that the numbering of the annual catalogs was adjusted in 1960 and again in 1971. For example, NAWA designated the annual exhibition in 1960 as the 70th Anniversary Exhibition after 1959 was the 67th Annual Exhibition. These adjustments appear to have been made to reflect the date of the founding of the association, so that, by 1989, the annual exhibition commemorated the 100-year anniversary of the founding of NAWA in 1889.
Dynamical chaos in the problem of magnetic jet collimation
Creators: name: Bisnovatyi-Kogan, G. S.
name: Neishtadt, A. I.
name: Seidov, Z. F.
name: Tsupko, O. Yu.
name: Krivosheyev, Yu. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate dynamics of a jet collimated by magneto-torsional oscillations. The problem is reduced to an ordinary differential equation containing a singularity and depending on a parameter. We find a parameter range for which this system has stable periodic solutions and study bifurcations of these solutions. We use Poincaré sections to demonstrate existence of domains of regular and chaotic motions. We investigate transition from periodic to chaotic solutions through a sequence of period doublings.
description: 11 pages, 29 figures, 1 table, MNRAS (published online)
Policy approaches for enhanced dairy sector innovation: A review of future pathways and policies for effective implementation of digital agriculture
Creators: name: Eastwood, Callum
name: Knook, Jorie
name: Turner, James
name: Renwick, Alan
Publisher: name: AgResearch
Year: 2023
Subjects: Agriculture, land and farm management

description: Innovation and technology are a feature of New Zealand’s dairy sector. To overcome current challenges, dairy farmers require agile and multi-dimensional innovation, supported by forward-looking and integrated policy from both the sector and government. In this paper, we outline some of the current dairy sector challenges, and potential technologies to address these challenges. We focus on the future for digital agriculture innovation and discuss policy approaches to enable the sector to leverage digitalisation. These approaches include co-innovation, responsible innovation, multi-scale approaches, micro-innovation and poly-innovation and mission-oriented innovation. Digital agriculture and policy may interact in two ways: (1) policy may be used to enhance digital agriculture innovation and, (2) digitalisation itself may act to enhance agricultural policy design and delivery. Overall, innovation policy requires greater directionality, use of policy bundles and a focus on technology as a mediator of new dairy farming practices and institutional configurations. NZBIDA
Bret2 Assay Using The Fdss/?Cell: Monitoring Cell Surface-Receptor Internalization And Intracellular Trafficking
Creators: name: D'Angelo, Jean Marc
Publisher: name: Zenodo
Year: 2015
Subjects: receptor internalization and intracellular trafficking

description: After the publication of application note n?23 describing BRET1 technology and based on a study published in 2011, Pierre Fabre Research Institute recently implemented the more sensitive BRET2 technology to the FDSS?Cell system for monitoring the internalization of the human dopaminergic D2s receptor, a prototypic G protein-coupled receptor (GPCR).  The result of this work will be present.
Electric Field Stimulation (Efs) Of Human Ipsc-Derived Neuron Using Hamamatsu Fdss/?Cell
Creators: name: D'Angelo, Jean Marc
Publisher: name: Zenodo
Year: 2015
Subjects: Electric field stimulation (EFS)
Human iPSC-derived neuron
FDSS/ucell

description: Hamamatsu developed a 96-channel electrode array system that is mounted on the FDSS/?CELL. It adds electric field stimulations (EFS) to all 96 wells in a microplate simultaneously while fluorescence/luminescence signals are monitored. Using this instrumental setup, we electrically stimulated human iPSC-derived neurons (iCell? Neurons, Cellular Dynamics International) to evoke a Ca2+ response, transient increase of intracellular Ca2+ concentration, which was measured with calciumsensitive fluorescent dyes.
Direct imaging of the coexistence of ferromagnetism and superconductivity at the LaAlO3/SrTiO3 interface
Creators: name: Bert, J. A.
name: Kalisky, B.
name: Bell, C.
name: Kim, M.
name: Hikita, Y.
name: Hwang, H. Y.
name: Moler, K. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: LaAlO3 and SrTiO3 are insulating, nonmagnetic oxides, yet the interface between them exhibits a two-dimensional electron system with high electron mobility,1 superconductivity at low temperatures,2-6 and electric-field-tuned metal-insulator and superconductorinsulator phase transitions.3,6-8 Bulk magnetization and magnetoresistance measurements also suggest some form of magnetism depending on preparation conditions5,9-11 and suggest a tendency towards nanoscale electronic phase separation.10 Here we use local imaging of the magnetization and magnetic susceptibility to directly observe a landscape of ferromagnetism, paramagnetism, and superconductivity. We find submicron patches of ferromagnetism in a uniform background of paramagnetism, with a nonuniform, weak diamagnetic superconducting susceptibility at low temperature. These results demonstrate the existence of nanoscale phase separation as suggested by theoretical predictions based on nearly degenerate interface sub-bands associated with the Ti orbitals.12,13 The magnitude and temperature dependence of the paramagnetic response suggests that the vast majority of the electrons at the interface are localized, and do not contribute to transport measurements.3,6,7 In addition to the implications for magnetism, the existence of a 2D superconductor at an interface with highly broken inversion symmetry and a ferromagnetic landscape in the background suggests the potential for exotic superconducting phenomena.
description: Edited version to appear in Nature Physics
A Novel, Microstructured, Polymer-Based Metal Enhance Fluorescence (Mef) Substrate Using Established Industrial Molding And Coating Processes Derived From Blu-Ray Disc Manufacturing For The Use In Ultra-Sensitive Fluorescence Immunoassays
Creators: name: Hawa, Gerhard
Publisher: name: Zenodo
Year: 2015
Subjects: diagnostics
immunoassay
plasmonic
sensitive
fluorescence

description: The quantification of serum biomarkers have become an essential part of modern medical science. As these are often present only in very small amounts, there is a permanent need for raising the sensitivity of the assay methods to increase reliability of study results.

Metal-enhanced fluorescence (MEF) is a promising technology to deliver such highly sensitive tests. MEF is based on the electromagnetic interaction of excitation light with nanometre-sized metal structures, which dramatically increases the quantum yield of fluorescent molecules in the immediate vicinity of the metal structures. This increase in light yield can be used to generate highly sensitive biomarker tests. Successful commercialization of clinical tests based on MEF depend on highly reproducible manufacturing of the required nano-metal structures and development of suitable bioassays for that platform. FIANOSTICS and Sony DADC BioSciences have developed such a new MEF platform and bioassays for clinical research which are compatible to any given assay format (e.g. microtiter plate, microfluidic chips, arrays or lateral flow devices etc.) using Sony DADC's established industrial processes.

Here we present initial data on a microstructured polymer based substrate which receives its metal layer using industrially established sputtering processes. Initial results using this substrate indicate that this novel MEF platform has an increase in sensitivity up to one order of magnitude compared to a colloid-silver based reference system.

The advantage of the invention is that the highly sensitive substrate is manufactured using established processes leading to highly reliable, easy to use products at potentially competitive prices.
Skill Centre Trainees and Their Employers, 1976
Creators: name: Berthoud, R. G.
Publisher: name: UK Data Service
Year: 1981

description: The aim of this survey was to study the relation between the publicly sponsored training of adults at skillcentres and the local markets which they serve. Two skillcentres were studied in detail, at Stoke-on-Trent and at Dundee. A survey was conducted of the men who completed courses at either skillcentre over a three-year period, and this was followed by a survey of the employers who had hired those same men to work with the skills to which they had been introduced.
Increased Spr-Sensitivity Enables Fragment Screening And Kinetic Characterization At Lower Surface Densities
Creators: name: Roder, Uwe
Publisher: name: Zenodo
Year: 2015
Subjects: Biacore
SPR
Fragment
FBDD

description: Fragment-based drug design is increasingly used to identify suitable scaffolds in drug discovery. Whilst providing many advantages, working with low molecular weight fragments also impose challenges. Apart from inherently weak affinities in combination with low molecular weight, one has to handle solubility issues and secondary interactions that may appear at high concentrations. High sensitivity instrumentation is required to observe and verify binding, and the use of difficult targets increases the need for sensitivity even further. Software tools that take the challenges of working with fragments into account shortens the time to results, and increase the confidence in affinity estimations for LMW fragments.  Surface Plasmon Resonance (SPR) is firmly established as a powerful technology within FBDD due to its sensitivity, low target consumption, and high quality information-rich data. In this study we highlight the features of the new Biacore? S200 system. This system is specifically designed for high sensitivity combined with increased productivity in fragment screening and kinetic characterization. With a sensitivity increase of 50% compared to current Biacore systems, it enables screening and characterization at lower surface densities. Using this approach, we will exemplify how working with milli-RU levels of dose response can facilitate routine analysis of challenging targets, and how the work with low surface densities will enable the interpretation of data.
Project planning and control in a consulting environment
Creators: name: Curren, James E.
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: HE 151 C87 1990
subject: Transportation - Planning
subject: Transportation consultants

description: Bibliography: p. 175-177.
description: Project management has become well accepted as a management form within many large organizations and for the construction of most capital projects. However, there are many other fields or endeavors where the work of professionals can be defined as project work. Transportation consulting is one such field. Presently the distinction between functional management and project management is not well understood and as a consequence project management is practiced only to a limited degree. This thesis examines current practices in the field, obstacles to effective project management, and develops a framework for implementing more effective planning and control techniques. The individual elements of planning and control are discussed. The integration of project planning and control elements through the use of a Work Breakdown Structure is examined. Practical concerns relating to implementation of these techniques are addressed. Establishing effective planning and control techniques is not difficult, although by the nature of a consulting practice the initiative lies more with individual project managers then in large organization undertaking large capital projects. Small consulting practices do not have the ability to maintain the administrative overhead that larger organizations do. As a consequence project management is an approach to work that must be practiced at an individual level.
Anne Cauquetoux (éd.), Jean-Baptiste Colbert. Le bâtisseur, Toulouse (Éditions Privat) 2019
Creators: name: Le Person, Xavier
Publisher: name: Francia-Recensio
Year: 2020

description: Anne Cauquetoux (éd.), Jean-Baptiste Colbert. Le bâtisseur, Toulouse (Éditions Privat) 2019, 163 p. (Privat histoire), ISBN 978-2-7089-5642-1, EUR 16,90.
description: Francia-Recensio, 2020/3
Strong Purcell effect observed in single thick shell CdSe/CdS nanocrystals coupled to localized surface plasmons
Creators: name: Canneson, D.
name: Mallek-Zouari, I.
name: Buil, S.
name: Quélin, X.
name: Javaux, C.
name: Mahler, B.
name: Dubertret, B.
name: Hermier, J. -P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: High quality factor dielectric cavities designed to a nanoscale accuracy are mostly used to increase the spontaneous emission rate of a single emitter. Here we show that the coupling, at room temperature, between thick shell CdSe/CdS nanocrystals and random metallic films offers a very promising alternative approach. Optical modes confined at the nanoscale induce strong Purcell factors reaching values as high as 60. Moreover the quantum emission properties can be tailored: strong antibunching or radiative biexcitonic cascades can be obtained with high photon collection efficiency and extremely reduced blinking.
description: 16 pages, 7 figures
Johannes Paulmann, Globale Vorherrschaft und Fortschrittsglaube. Europa 1850–1914, München (C. H. Beck) 2019
Creators: name: Deluermoz, Quentin
Publisher: name: Francia-Recensio
Year: 2020

description: Johannes Paulmann, Globale Vorherrschaft und Fortschrittsglaube. Europa 1850–1914, München (C. H. Beck) 2019, 486 S., 4 ill. (C. H. Beck Geschichte Europas. C. H. Beck Paperback, 1986), ISBN 978-3-406-62350-9, EUR 19,95.
description: Francia-Recensio, 2020/3
Using Signaling Pathway Activation Analysis To Identify Prospective Drugs That May Slow Down Or Reverse The Effects Of Skin Aging And Photo-Aging
Creators: name: Mamoshina, Polina
name: Aliper, Alex
name: Artemov, Artem
name: Schastnaya, Evgenia
name: Buzdin, Anton
name: Moskalev, Alexey
name: Zhavoronkov, Alex
Publisher: name: Zenodo
Year: 2015
Subjects: Skin aging
Photo aging
Gero Scope
OncoFinder

description: Skin aging is a complex process, which is still poorly understood on the molecular level and cause and effect relationships between the many factors. However, most experts agree that solar radiation is the one of the major factors in skin aging. Recent studies demonstrate that modern sunscreen compounds do not provide complete protection and most of the UV-filters shows cytotoxic ability and may have serious side effects.

To explore signaling and metabolic pathway regulation during skin-aging process we used the GeroScope platform, based on the OncoFinder algorithm used in personalized medicine in oncology. We used over two thousand publically available samples of aged and photo-aged skin and various skin cell types to analyze pathway dysregulation during aging and photo-aging. We evaluated the activity of over 40,000 compounds for their ability to mimic signaling pathway activation profiles characteristic of young skin to shortlist potential candidates. We cross-reference the candidate molecules with the recently launched Geroprotectors.org database. We applied the PharmAtlas tools to estimate the possible adverse effects of compounds with reports odds ratio (ROR) and predicted adverse effects for compounds that did not have reports of adverse effects using signaling pathway activation similarity.
Daughters of empire: British gentlewomen in Alberta, 1880-1914
Creators: name: Curtin, Emma Jane
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: FC 106 B7 C87 1990
subject: Women immigrants - Alberta - Social conditions
subject: Women immigrants - Alberta - History
subject: Alberta - Gentry - History
subject: British - Alberta - History
subject: Women immigrants - Great Britain - History

description: Bibliography: p. 150-162.
Patch Them All - Fully Hts-Compatible Automated Patch Clamping Of 384 Cells At Once For Massively Parallel Ion Channel Screening
Creators: name: Rinke, Ilka
Publisher: name: Zenodo
Year: 2015
Subjects: Patch Clamp
High Throughput Screening
CiPA
Safety
stem cells

description: Automated patch clamping is well established within academic research and drug discovery efforts. Still, there is a longstanding desire to have gold standard electrophysiology compatible with primary ion channel drug screening requirements. We here present a chip-based, modular approach for massively parallel patch clamp recordings. Using microstructured glass bottom microtitre plates, recordings from 384 cells are performed in an automated fashion. The recording system contains 384 patch clamp amplifiers and is integrated into existing, state-of-the-art 384 head pipetting robots, so all experiments are done in parallel, resulting in a throughput of several thousand data point per hour. Such a robust and modular approach is themselves easily integrable into HTS environment. Finally patch clamp has gone HTS! Success rates achieved are routinely over 85 %. A complete run takes less than 15 minutes. From single point application to cumulative dose responses, there are no limitations with the number of additions. Solution onset is fast, <50 ms, current responses are highly reproducible and brief compound exposures, <1s, can be obtained.
Translating Research into Practice in Africa
Creators: name: Sankah, Beatrice E.A.
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420104
subject: Occupational therapy
classificationCode: 420106
subject: Physiotherapy
classificationCode: 420105
subject: Orthoptics
classificationCode: 420107
subject: Podiatry
classificationCode: 420108
subject: Prosthetics and orthotics
classificationCode: 420109
subject: Rehabilitation
classificationCode: 420110
subject: Speech pathology
classificationCode: 420199
subject: Allied health and rehabilitation science not elsewhere classified

description: This presentation is part of a Discussion Forum on the theme - Translating Research into Practice in Africa at the World Physiotherapy Africa Region Congress on 14th September 2024; Cape Town, South Africa.The aim of the presentation as part of the discussion forum was to set the scene for the panel discussion on the topic by exploring the research to practice gap in Physiotherapy. More specifically, the brief presentation aimed to discuss what it means to translate research into practice in Africa from both scientific and experiential perspectives. I believe this information will provide you with insights into challenges and ways to address the research to practice gap in Physiotherapy and the rehabilitation fraternity.
High Fidelity Small Molecule Dna-Encoded Yoctoreactor Libraries
Creators: name: Petersen, Lars
Publisher: name: Zenodo
Year: 2015
Subjects: DNA-encoded small-molecule libraries
yoctoreactor libraries
Binder Trap Enrichment (BTE)
bromodomain inhibitors
BRD4
kinase inhibitors
p38a
drug discovery

description: Yoctoreactor technology (yR) is employed to generate DNA-encoded small molecule libraries of maximum fidelity for seamless drug discovery. Through efficient self-assembly of DNA oligonucleotides, 3D DNA structures are formed ? each is serving as a small chemical reactor. Building blocks covalently linked to the DNA oligonucleotides are thus pre-organized in the center of a DNA junction, and chemical reactions can take place efficiently due to the proximity effect. The DNA acts both 1) as a structural director for the chemical reactions and 2) as a distinct barcode from which each library member may be identified by DNA sequencing. All this is possible in a single-tube format due to a tight correspondence between DNA codes and the molecules synthesized. Herein we describe the assembly and analysis of a multi-million membered small molecule library that was prepared using the yR technology - including a comparison to various standards for drug-likeness. Furthermore, the yR library was interrogated using proprietary Binder Trap Enrichment technology (BTE) which is a homogeneous screening method. This method employs a unique principle of trapping small molecule binders together with the protein target in miniscule droplets and enables direct identification of potent inhibitors directly from the library. Case stories will be presented, including interleukin 6 receptor (IL-6R) ? a clinically validated protein ? protein interaction target which is implicated in cancer and multiple inflammatory and autoimmune diseases. Potent inhibitors were also identified for traditional target, e.g. p38-alpha kinase. In both examples, nanomolar inhibitors were identified directly from the library without hit maturation.
Zusammenfassung: Schein-Mauerverbände in der almohadischen Architektur in Portugal. Erste Beiträge auf der Grundlage von Materialität und Quelle
Creators: name: Villalba Sola, Dolores
Publisher: name: Miradas - Zeitschrift für Kunst- und Kulturgeschichte der Américas und der iberischen Halbinsel
Year: 2020

description: Bauschmuck in Form eines falso despiece (Scheinverband) ist eine Oberflächenbehandlung von Mauern, die auf vertikalen und horizontalen Linien basiert. Dieser Schmuck kennzeichnet die almohadische Architektur und erscheint vor allem im Kontext von Wehrbauten, woher seine Verbreitung und Bedeutung stammt. Allerdings wurde er bislang kaum untersucht, trotz seiner Bedeutung, die daraus resultiert, dass er es emöglicht, die Bauten fast exakt in eine sehr konkrete Zeit des almohadischen Kalifats zu datieren – zwischen den Kalifaten von Abū Yaʿqūb Yūsuf Ibn ʿAbd al-Muʾmin Ibn ʿAlī und von Abū Yūsuf Yaʿqūb Ibn Yūsuf Ibn ʿAbd al-Muʾmin Ibn ʿAlī (al-Mansūr). Tatsächlich gehören die Beispiele auf portugiesischem Territorium zu den am wenigsten bekannten und erforschten, trotz ihrer wesentlichen Bedeutung, da sie genau datiert sind, wodurch sie als Vorbild für andere Überreste verwendet werden können, bei denen der gleiche Dekortypus erhalten ist.
description: Miradas - Zeitschrift für Kunst- und Kulturgeschichte der Américas und der iberischen Halbinsel, Bd. 3 (2016): Miradas
Validation Of A New Optical Method For Ion Channel Screening
Creators: name: Grohovaz, Fabio
Publisher: name: Zenodo
Year: 2015
Subjects: ion channels
drug screening
voltage sensitive dyes

description: Menegon A.1, Agus V.2, Crespi D.2, Rolland J.F.2, Redaelli L.2, Scarabottolo L.2, Seneci P.3, Mazzocchi N.1, Imberti M.4, Poli C., Lanati A.5, Grohovaz F.1,6

1. SanRaffaele Scientific Institute, Milan; 2. Axxam SpA, Bresso (MI); 3. University of Milan, Milan; 4. OPEN Sistemi srl – Cremona; 5. Valore Qualità, Pavia; 6. San Raffaele University, Milan.

Numerous top-selling drugs are ion-channel modulators. Unfortunately, the screening of candidate molecules for ion channels is mostly based on optical approaches that measure, as final readout, a cascade of events rather than direct channel activation. Overall these approaches are compatible with high throughput requirements but can be poorly predictive. Alternative methods, such as manual or automated patch clamp technologies, are valuable but expensive and time consuming. The poster illustrates the validation of a new Optical Method for Ion Channel Screening patented in Europe and pending acceptance in the USA (EP2457088, WO2011009825, US13/386225). This innovative approach, based on the study of ion channel conductance by a fluorescence-based approach, was implemented in a fully automated system built according to EC standards. When this platform was tested on different ion channel targets, the results were in good agreement with those reported in literature by gold standard approaches (manual and automated patch clamp). Finally, the platform was challenged with a small library of candidate molecules acting on the P2RX7 ion channel and the results were compared with those obtained by FLIPR and QPatch. Also in this case, the results were comparable with those obtained by the established screening approaches. Overall, we demonstrate that this new platform allows the study of different ion channels, independently of the way they are operated, of their specific permeability, and of the extent of the ionic flux sustained at rest. This innovative platform provides an excellent compromise of cost per data point, throughput and prediction power in drug screening.
Reading Diary Survey, 1973
Creators: name: Steadman, J. P.
name: Dickens, P. G.
name: March, L. J.
Publisher: name: UK Data Service
Year: 1982

description: To investigate people's use of time in towns. It was expected that this study would be relevant to various planning and administrative concerns, such as peak hour traffic congestion, the timing of public transport services, the introduction of flexible working hours, extensions of shop opening hours, the reform of pub licensing laws, and patterns of leisure activity.
Forcing scheme in pseudopotential lattice Boltzmann model for multiphase flows
Creators: name: Li, Q.
name: Luo, K. H.
name: Li, X. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The pseudo-potential lattice Boltzmann (LB) model is a widely used multiphase model in the LB community. In this model, an interaction force, which is usually implemented via a forcing scheme, is employed to mimic the molecular interactions that cause phase segregation. The forcing scheme is therefore expected to play an important role in the pseudo-potential LB model. In this paper, we aim to address some key issues about forcing schemes in the pseudo-potential LB model. Firstly, theoretical and numerical analyses will be made for Shan-Chen's forcing scheme and the exact-difference-method (EDM) forcing scheme. The nature of these two schemes and their recovered macroscopic equations will be shown. Secondly, through a theoretical analysis, we will reveal the physics behind the phenomenon that different forcing schemes exhibit different performances in the pseudo-potential LB model. Moreover, based on the analysis, we will present an improved forcing scheme and numerically demonstrate that the improved scheme can be treated as an alternative approach for achieving thermodynamic consistency in the pseudo-potential LB model.
description: 7 figures
An Insight Into The Interaction Of Oxo-Vanadium (V) Complex With Nucleic Acid
Creators: name: Tripathi, Mamta
Publisher: name: Zenodo
Year: 2015
Subjects: Oxo-Vanadium (V) Complex
nucleic acid
binding

description: Vanadium complex show protective effects against chemical carcinogenesis on animals, by altering, mainly, various xenobiotic enzymes, inhibiting, thus, carcinogen-derived active metabolites. Studies on various cell lines reveal that vanadium exerts its antitumor effects through inhibition of cellular tyrosine phosphatases and/or activation of tyrosine phosphorylases. It also possesses low toxicity. In combination with the synthesis of new, more potent and better tolerated complexes, these are reported as an effective non-platinum, metal antitumor agent. N-Aryl hydroxamic acids (RC (=O)N(OH)R?) as a chelating agents form highly stable complex with Vanadium(V). The binding parameters of Vanadium(V) complex of the parent compound of this series, i.e., N-Phenylbenzohydroxamic acid (PBHA) complex using calf thymus DNA (ct-DNA) and torula yeast RNA (t-RNA) have been determined and reported first time following the UV, fluorescence and viscometric techniques. The complex shows the ability of cooperatively minor groove binding with ctDNA as indicated by remarkable hyperchromicity and blue shift of the absorption spectra. Quenching of metal complex calculation was carried out with Stern-Volmer equation and Ksv was found to be 2.32?0.18?104 M -1 , while in case of t-RNA enhancement is observed that means compound was not able to displace ethidiumbromide (EB)-t-RNA complex. Molecular docking was also applied, result complements and predicted as minor groove as the mode of interaction of the hydroxamic acid with ct-DNA and t-RNA.
Didepsid Atranorin Shows Selective Cytotoxic Effect On Flatworm Mesocestoides Vogae In Vitro And In Vivo Whereas Exerting Immunomodulatory And Protective Effects In Vivo In Experimental Mouse Infection.
Creators: name: Hr?Kova, Gabriela
Publisher: name: Zenodo
Year: 2015
Subjects: atranorin
flatworm larvae
metabolism
mouse infection
immunomodulation

description: A member of a group of secondary lichen metabolites, didepsid atranorin (ATR, MW 372) has been shown to exert anti-cancer, antioxidant and anti-inflammatory effects in vitro. In the present study we examined its effect on the infection with proliferating larval stage of model cestode Mesocestoides vogae. Significant larvicidal effect of ATR in vitro was seen at concentration 100 ?M, as was demonstrated by motility and viability tests and disruption of metabolic homeostasis. Reduction of larvae was observed after total dose of 300 mg/kg b.w. given in 10 daily doses. Intensity of oxidative stress in the liver was diminished after ATR administration indicated from elevated glutathione levels and decreased lipid peroxides what correlated with decreased hydroxyproline concentrations used as fibrosis marker. We also assessed time- and dose-dependent cytotoxic and immunomodulatory activity of ATR on na?ve and mitogen-stimulated splenocytes and macrophages in vitro and in vivo using the following tests: MTT and lymphocyte proliferation test, ELISA assays for cytokine profile (IFN-g, TNF-?, IL-4, IL-10, IL-17, TGF-?), western blot analysis for quantification of pro- and anti-apoptotic proteins BAX and Bcl-xL, resp. Level of apoptosis was examined by Flow cytometry using annexin/PI Kit and fluorescent microscopy. ATR was cytotoxic for naive immune cells at concentrations ? 50 ?M and incubation time ? 24 h in vitro, whereby in vivo it showed imunomodulating and anti-apoptotic effect on immune cells. We also have demonstrated for the first time its antiparasitic and anti-fibrotic effect.

(Support to this work was given by Grant Agency VEGA, project no. 2/0150/13). 
Analysis Of Rna Editing In Non-Human Primates
Creators: name: Bozinoski, Marjan
name: Mason, Chris
Publisher: name: Zenodo
Year: 2015
Subjects: RNA Editing
NGS
RNA-Seq

description: Adenosine deaminases acting on RNA (ADAR) mediated RNA editing is the prevalent form of post-transcriptional RNA modification in higher organisms. Deaminated Adenosine creates Inosine, which is recognized as Guanosine thereby causing changes in the coding sequence, splicing and miRNA binding. RNA editing is mostly primate specific phenomenon and few studies of limited scope have shown that humans possess more editing sites than other primates.

Here, we present the extent and intensity of RNA editing in non-human primates using a dataset where we analyze 21 polled tissues from 15 primate species/subspecies, spanning approximately 70 million years of primate evolution. Additionally, we analyze RNA editing in tissue specific manner, using data from 14 separate sequenced tissues from each of the species. Our results show that primates show less RNA editing than humans, with baboon, gorilla and chimp showing 19.7% 13.4% and 12.1% less editing sites respectfully, perfectly fitting within the phylogenetic tree.

Expanding the analysis in tissue-specific manner, we observe distinct conservation of RNA editing sites throughout the different brain regions, with ones phylogenetically closest to human showing more human-like distributions. Additionally, we accessed the topology of the identified RNA editing sites in non-human primates, which revealed a surprising portion of the edited sites being in non-coding transcripts, thereby implicating a regulatory role. Further analysis of the editing sites in the coding regions of the transcripts show that edited codons are much more likely to be non-synonymous than synonymous (4:1 ratio), further more stressing the importance of RNA editing as regulatory mechanism.
Interest groups and Canadian broadcasting regulation: an examination of Mediawatch
Creators: name: Davison-Leong, Janis
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: HE 8689.7 C55 D38 1990
subject: Broadcasting policy - Canada - Citizen participation
subject: Mediawatch
subject: Canadian Radio-Television and Telecommunications Commission
subject: Sex role in mass media - Canada

description: Bibliography: p. 211-223.
Establishing spin-network topologies by repeated projective measurements
Creators: name: Bretschneider, Christian O.
name: Alvarez, Gonzalo A.
name: Kurizki, Gershon
name: Frydman, Lucio
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: It has been recently shown that in quantum systems, the complex time evolution typical of many-bodied coupled networks can be transformed into a simple, relaxation-like dynamics, by relying on periodic dephasings of the off-diagonal density matrix elements. This represents a case of "quantum Zeno effects", where unitary evolutions are inhibited by projective measurements. We present here a novel exploitation of these effects, by showing that a relaxation-like behaviour is endowed to the polarization transfers occurring within a N-spin coupled network. Experimental implementations and coupling constant determinations for complex spin-coupling topologies, are thus demonstrated within the field of liquid-state nuclear magnetic resonance (NMR).
description: 4+ pages, 3 figures
Rapid Analysis And Quantification Of Proteins In High Throughput Using Paia Assays
Creators: name: Wosnitza, Christine
name: Giehring, Sebastian
name: Lechner, Kristina
Publisher: name: Zenodo
Year: 2015
Subjects: protein quantification
high producer screening
cell line development
high throughput
IgG

description: The PAIA technology is a novel approach to quantify proteins. The protein of interest (the analyte) is captured by functionalized beads and detected with a specific fluorescence marker. PAIA assays use protrusions on the bottom of 384-well microplates to separate captured analyte-marker complexes from the unbound fluorescent marker which is then measured (Figure 1). The assay is automation-friendly since no washing steps are needed. Thus, time to result, sample volume, and hands-on time are substantially reduced compared to other immunoassay formats. The PAIA approach has been successfully used for IgG quantification in supernatants of antibody producing cells and a PAIA IgG kit has already been launched. Because it is possible to choose a marker against a selective epitope of the analyte the PAIA technique can address a broad range of analytes. Here, we present assay systems that are currently under development e.g. for analytes that contain affinity tags. Analytes carrying two tags can be captured via the first tag while the fluorescence marker binds the second tag. Figure 2 shows an example of proteins that were captured by their Strep-tag and detected by a Flag-tag specific marker. For proteins with just one tag or epitope, competitive assays are more suitable. In these assays the fluorescence marker contains the same tag or epitope as the analyte and both compete for binding sites on the capture beads. We believe that the high throughput, the small sample volume, and the low overall costs of PAIA assays represent substantial advantages over existing methods.
Adenosine A1 And A2A Receptors As Possible Biomarkers In Peripheral Cells From Idiopathic Normal-Pressure Hydrocephalus Patients
Creators: name: Arosio, Beatrice
Publisher: name: Zenodo
Year: 2015
Subjects: Adenosine A1 receptor
adenosine A2A receptors
biomarkers
idiopathic normal-pressure hydrocephalus

description: Introduction. Idiopathic normal-pressure hydrocephalus (iNPH) is a neurological disease that develops in elderly. It has been hypotized that cerebrovascular disease could have a role in etiolology of hydrocephalus. Evidences show a possible alteration of immune system in iNPH patients. Adenosine (Ado) is a metabolite produced in response to ischemia, hypoxia, inflammation and trauma. The effects of Ado are transduced through four subtypes of receptors: A1 (A1R), A2A (A2AR), A2B and A3.

Aim. The aim is to evaluate expression of A1R and A2AR in peripheral blood mononuclear cells (PBMCs) from iNPH compared to control subjects (CT). We investigate if Ado system, that plays an important role in CNS, in vascular system, and in inflammation, is involved in pathophysiology of iNPH.

Results. We analysed 22 iNPH and 50 CT age and gender-matched. Data showed that A1R mRNA levels in PBMCs from iNPH were significantly lower than CT (0.84±0.12 and 2.42±0.42, respectively; p=0.001) as well as A1R density (0.31±0.02 and 0.42±0.04; p=0.043). A2AR gene expression was significantly lower in iNPH than CT (0.65±0.09 and 1.5±0.14; p<0.001).

Conclusions. Since PBMCs may provide a window into the CNS, we could speculate that there is a down-regulation of these receptors also in the CNS. Since Ado receptors control the dynamics of brain vasculature and of inflammation, we could assume that the down-regulation of A1R and A2AR may have a key role in iNPH. Our findings underline the role of Ado system in iNPH as peripheral marker of this disease with unknown pathophysiology.
Job Search Module Project, 1978-1980
Creators: name: Manpower Services Commission, Employment Rehabilitation Research Centre
Publisher: name: UK Data Service
Year: 1981

description: The aim of this survey was to evaluate the effects of job search training on the post-course job seeking behaviour of former Employment Rehabilitation Research Centre clients. The survey reports the results of interviews with a sample of approximately 200 Employment Rehabilitation Centre clients on their job-seeking activities over a period of three months following completion of ERC course attendance. The sample had been randomly allocated on arrival at ERC into `experimental' and `control' group streams in a two-stream ERC. The experimental group received normal ERC courses wwith job search training as an addition; the control group received normal courses but without such training.
Lateinische Inschriften aus Losheim und Tholey
Creators: name: Moreau, Jacques
Publisher: name: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete
Year: 2020

description: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete, Bd. 22 Nr. 1/2 (1953): Trierer Zeitschrift : für Geschichte und Kunst des Trierer Landes und seiner Nachbargebiete
Runcorn Household Survey, 1978
Creators: name: Whitworth, A.
name: Morgan, A. M.
Publisher: name: UK Data Service
Year: 1982

description: The aim of the study was to provide a snapshot profile of the Runcorn New Town population of 1978 in terms of age structure, employment, car ownership, etc.
Fluorescence And Docking Studies On The Binding Of Copper And Cobalt Complexes To Dna And Rna
Creators: name: Thakur, Yamini
name: Pande, Rama
Publisher: name: Zenodo
Year: 2015
Subjects: hydroxamic acid
DNA
RNA
fluorescence
docking

description: Nucleic acid are involved in fundamental biological functions as propagation of the genetic material, storage of genetic information and enzymatic activity. A high-throughput screen is necessary to identify compounds that bind to the target with high affinity, for developing new drugs that target with high affinity, for developing new drugs that target the DNA/RNA. Hydroxamic acids, the drug like molecules show both HBD and HBA capability.
Chasing the honey money: Transparency, trust, and identity crafting in the Aotearoa New Zealand mānuka honey sector
Creators: name: Finlay-Smits, Susanna
name: Ryan, Alyssa
name: de Vries, Jasper
name: Turner, James
Publisher: name: AgResearch
Year: 2023
Subjects: Agriculture, land and farm management

description: Advances in digital technology are altering the methods through which trust is established and maintained within value chain relationships, including those within the Aotearoa New Zealand mānuka honey sector, where the increasing value of the honey and the increasing threat of food fraud have impacted power dynamics between value chain actors. This paper explores how three Aotearoa New Zealand mānuka honey companies have responded to these changes, focusing on their efforts to craft and convey images of themselves as trustworthy producers and partners. To this end the companies are seen to use digital technologies in their attempts to establish character-based, institution-based, and process-based trust with those in their value chains by displaying their ability, integrity, and benevolence. NZBIDA
Spatial distribution of spin-wave modes in cylindrical nanowires of finite aspect ratio
Creators: name: Dolocan, Voicu O.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The spin wave modes of cylindrical nanowires of moderate diameter-to-length ratio are investigated in this article. Based on three dimensional simulations and analytical calculations we determine the spatial structure of the modes. We show that standing spin waves and localized edge modes form the discrete spectrum of the nanowires. Using a simple analytical model we infer an extended dispersion relation for spin waves in cylinders. Considering the variation of the demagnetizing (internal) field we show that the localized dipole-exchange modes at the edges are always present.
description: 8 pages, 5 figures
Ein Collegium Castorum in Trier : Betrachtungen zum Figurenmosaik vom Kornmarkt
Creators: name: Egger, Rudolf
Publisher: name: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete
Year: 2020

description: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete, Bd. 22 Nr. 1/2 (1953): Trierer Zeitschrift : für Geschichte und Kunst des Trierer Landes und seiner Nachbargebiete
Redbridge Jewish Survey, 1977-1978
Creators: name: Board Of Deputies Of British Jews, Community Research Unit
name: Alderman, G.
Publisher: name: UK Data Service
Year: 1982

description: The aim of this study was to survey Jewish housholds in the London Borough of Redbridge to determine the size, age structure, religious practices, education, extent of Zionist commitment, movement and family history, and related characteristics of Redbridge Jewry.
National Association of Women Artists 70th Anniversary Exhibition, May 12 - May 29th, 1960
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1960

description: The National Association of Women Artists (NAWA) was established in 1889 and is the oldest professional women's fine arts organization in the United States. NAWA's mission is to promote awareness of, and interest in, visual art created by women in the United States. As part of this effort NAWA holds an annual exhibition of works by members of the association and publishes an exhibition catalog to accompany or commemorate the annual exhibitions. These catalogs not only function as an exhibition catalog, but also as a document that summarizes the structure, membership, and activities of the association.Information that can be found in these catalogs includes lists of officers, members of the executive board and committees, prize winners, lists of exhibitor and members, and images of some of the artwork exhibited. Catalogs from the 2000s also include information on NAWA events and activities beyond the annual exhibition.Please note that the numbering of the annual catalogs was adjusted in 1960 and again in 1971. For example, NAWA designated the annual exhibition in 1960 as the 70th Anniversary Exhibition after 1959 was the 67th Annual Exhibition. These adjustments appear to have been made to reflect the date of the founding of the association, so that, by 1989, the annual exhibition commemorated the 100-year anniversary of the founding of NAWA in 1889.
Learning from Galileo's errors
Creators: name: Bernieri, Enrico
Publisher: name: arXiv
Year: 2012
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: Four hundred years after its publication, Galileo's masterpiece Sidereus Nuncius is still a mine of useful information for historians of science and astronomy. In his short book Galileo reports a large amount of data that, despite its age, has not yet been fully explored. In this paper Galileo's first observations of Jupiter's satellites are quantitatively re-analysed by using modern planetarium software. All the angular records reported in the Sidereus Nuncius are, for the first time, compared with satellites' elongations carefully reconstructed taking into account software accuracy and the indeterminacy of observation time. This comparison allows us to derive the experimental errors of Galileo's measurements and gives us direct insight into the effective angular resolution of Galileo's observations. Until now, historians of science have mainly obtained these indirectly and they are often not correctly estimated. Furthermore, a statistical analysis of Galileo's experimental errors shows an asymmetrical distribution with prevailing positive errors. This behaviour may help to better understand the method Galileo used to measure angular elongation, since the method described in the Sidereus Nuncius is clearly wrong.
description: 8 pages, 5 figures, 2 tables