cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk assessment for nitrosated pharmaceuticals: A future perspective in drug development
Creators: name: Schmidtsdorff, Sebastian
name: Neumann, Jonas
name: Schmidt, Alexander H.
name: Parr, Maria K.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: nitrite
subject: nitrosamines
subject: nitrosation assay procedure (NAP)
subject: N-nitroso compounds (NOC)
subject: porous graphitic carbon (PGC)
subject: supercritical fluid chromatography (SFC)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Since June 2018, thousands of drug products from around the world had to be recalled due to the unexpected presence of nitrosamines (NAs). Starting with the pharmaceutical group of sartans, antidiabetic drugs, antihistamines, and antibiotics also became the subject of investigation. The occurrence of NAs has shown that pharmaceutical companies and regulatory agencies did not focus on these substances in the past during drug development. In this study, we incorporated a nitrosation assay procedure into high-resolution supercritical fluid chromatography (SFC)–mass spectrometry screening to test the potential of direct nitrosation of active pharmaceutical ingredients (APIs). The forced degradation study was performed with a four-fold molar excess of sodium nitrite, relative to the drug substance, at pH 3–4 for 4 h at 37°C. Chromatographic separation was performed on a porous graphitic carbon column by SFC. The mass analysis then focused on direct N-nitrosation or N-nitroso compounds (NOCs) formed after dealkylation. Substances (n = 67) from various pharmaceutical classes were evaluated and 49.3% of them formed NOCs, of which 21.2% have not yet been reported in the literature. In addition, for two APIs, which are known to form an unidentified NOC, the structure could be identified. A few substances also showed multiple NOCs and even N,N’-dinitroso-species. As NAs are carcinogens, they have to be eliminated or at least limited to prevent cancer in patients, who rely on these drugs. This study contributes a procedure that can be implemented in preapproval drug development and postapproval risk assessment to prevent unexpected findings in the future.
DH als Perspektive für die Klassische Philologie
Creators: name: Beyer, Andrea
Publisher: name: Zenodo
Year: 2020
Subjects: Digital Humanities
Digital Classics
Machina Callida
Wortschatzerwerb
Vocabulary acquisition
Latin language

description: The talk introduces into the Digital Humanities and shows how the Classics might benefit from the knowledge and methods of the DH. The second part deals with the issue "vocabulary acquisition" and a newly developed digital tool (Machina Callida) that uses NLP to create corpus-based vocabulary exercises in Latin classes.
description: Funded by the German Research Foundation (DFG), project number 316618374
The pollen of Solanum L. and its systematic significance
Creators: name: Tiantian Du
name: Chunhai Zhao
name: Jiaxi Liu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology

description: The morphology of 75 different pollen grains from 67 species of genus Solanum L., two species of genus Cyphomandra Sendt., and six species of genus Lycianthes (Dunal) Hassl. was studied using light microscopy and scanning electron microscopy. Among them, the pollen of 66 species is described for the first time. Our results suggest that the sexine ornamention of Solanum, Cyphomandra and Lycianthes is extremely similar, but the apertures of genus Solanum and Cyphomandra are not syncolpate while those of genus Lycianthes are syncolpate. Overall, we argued that the Solanum species studied demonstrated sufficient pollinic heterogeneity in their shapes, aperture feature and sexine ornamentation to enable their palynological characterisation and support the point of view that the genus Cyphomandra should be merged into Solanum, but Lycianthes should be an independent genus from the aspect of palynology.
Flexible operation of electricity-intensive industrial processes
Creators: name: Ying Xuan, Iván
Publisher: name: Imperial College London
Year: 2019

description: The aim of this thesis is to study the flexibility of electricity-intensive industrial processes to adapt their electricity consumption to the available power. Electricity-intensive processes may use hundreds of megawatts during normal operation. An industrial site typically generates electricity locally and distributes it to electrical loads comprising the processes and other equipment. However, if an electrical contingency occurs, the available power reduces and the power consumed by the electrical loads must also reduce. Currently, a process power management system handles an electrical contingency by disconnecting loads until the total consumption of the site is lower than the remaining available power. This operation is named load shedding. If the shed equipment was essential for the process, then the whole process shuts down. The contribution of the thesis is to demonstrate that flexible process operation gives an alternative to load shedding. The concept is to reduce the power available to the process, so that the process can continue to operate but at a lower production rate. An electrical power outage occurs over a time scale of the order of 100ms. Therefore, in flexible operation, the power available to the process also reduces within 100ms. At the same time, the process control system must receive new set points so that the process moves to an operating point that is consistent with the available power. The thesis studied flexible operation of liquefaction of natural gas and aluminium smelting to find the set points for the process controllers as a function of available electrical power. Results show that the reduction in production rate can be ameliorated by adjusting other secondary process variables. The results also show that a process with significant energy storage such as aluminium smelting can continue operating for short periods of power reduction even with a very significant loss of available power. The final chapters of the thesis discuss how to generalize the study of flexible operation so that it can also be applied to other electricity-intensive processes.
A new specimen of Hsisosuchus (Mesoeucrocodylia, Crocodyliformes) from the Upper Jurassic of Yunnan, China with implications for the diversity of the ventral trunk shield of osteoderms in the genus
Creators: name: Wu, Liang
name: Wu, Xiao-Chun
name: You, Hai-Lu
name: Zhang, Yaotang
name: Zhao, Jianbo
name: Yuan, Yongsheng
name: Zhang, Honghui
name: Li, Shizhong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Hsisosuchus, with three known species, was the most common genus of crocodyliforms in the Sichuan Basin during the Jurassic. However, the overall shape of the ventral trunk shield of osteoderms has not been clarified due to the lack of complete specimens. A new specimen of Hsisosuchus recently recovered from the Upper Jurassic of Yunnan has the nearly complete ventral trunk shield preserved. This specimen provides an example for the first time for us to understand the shape and the way of the arrangement of the osteoderms in the ventral trunk shield in the genus. Compared with the articulated part of the ventral trunk shield preserved in two of the three species of the genus, the osteoderms of the ventral trunk shield of the new specimen are different in both shape and way of arrangement, indicating that the pattern of the ventral trunk shield is not constant within Hsisosuchus. With no skull and much of the postcranial skeleton poorly preserved as well as no corresponding element that can be used to compare with all the three species, the new specimen was considered as an indeterminate species of Hsisosuchus, awaiting more materials to clarify the problem.
Additional file 1 of Association between smoking and in-hospital mortality in patients with left ventricular dysfunction undergoing coronary artery bypass surgery: a propensity-matched study
Creators: name: Tang, Hanwei
name: Hou, Jianfeng
name: Chen, Kai
name: Huang, Xiaohong
name: Liu, Sheng
name: Hu, Shengshou
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1. Supplemental Appendices.
Design of a hybrid organosolv-ionosolv lignin fractionation method and lignin-like polymer synthesis for value added applications
Creators: name: Chen, Angela Meng
Publisher: name: Imperial College London
Year: 2019

description: Biofuel technology has been introduced to reduce the reliance on fossil fuels. It is also superior for addressing environmental issues, such as greenhouse gas (GHG) emissions. Biofuel production from lignocellulosic biomass has been attracting attention due to the high abundance of the feedstock and the incredible GHG emission reduction associated with the production process. Ionic liquid pretreament, the ionoSolv process, and organosolv pretreatment are well-known for their selective fractionation performance. The ionoSolv process is able to generate a highly digestible cellulose fraction and the organosolv process is famous for producing high quality lignin as the side product, where the lignin generated is suitable for value-added applications. Here, a hybrid pretreament process has been developed based on these two processes, where two protic ionic liquids and three organic solvents were the selected solvents. The new process has been tested on three classes of feedstocks, miscanthus, pine and agricultural residues. The pretreatment effectiveness was determined by enzymatic saccharification and compositional analysis. The isolated lignin fraction was subjected to HSQC and GPC analysis. For miscanthus, ethanol/butanol-IL process was able to produce a highly digestible pulp with a glucose yield of up to 85%, 10% higher than the standard ionoSolv pulp, due to more profound lignin removal for the hybrid process. The process maintained its functionality with a range of IL acidities, 1.00 to 1.02 (acid/base) and up to 50% wt biomass loading. Similar glucose yield increases were observed for pine, rice husk and bagasse. For the process of two straws, additional hemicellulose releases were detected in enzymatic hydrolysis while the level of glucose yields remained the same as for the ionoSolv ones. HSQC NMR of the lignin indicated that α-alkoxylation took place during ethanol/butanol-IL fractionation, inhibiting lignin condensation. Three major monolignols were synthesised and radical polymerisation induced by horseradish peroxidases was conducted for the monolignols synthesised. The lignin-like polymer was analysed by GPC.
Circum-Arctic Lithosphere Evolution (CALE) Transect C: displacement of the Arctic Alaska–Chukotka microplate towards the Pacific during opening of the Amerasia Basin of the Arctic
Creators: name: Miller, Elizabeth L.
name: Meisling, Kristian E.
name: Akinin, Vyacheslav V.
name: Brumley, Kelley
name: Coakley, Bernard J.
name: Gottlieb, Eric S.
name: Hoiland, Carl W.
name: O'Brien, Timothy M.
name: Soboleva, Anna
name: Toro, Jaime
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary material Plate 1 comprises Plate 1 and its included figures. Plate 1 contains regional reflection-seismic-based cross sections and supporting material that collectively constitute CALE Transects C1 and C2. Plate 1 is referred to in the text as Sup. Pl. 1, Transects C1 and C2 as Plate 1A and 1B, and plate figures as fig. P1.1, fig. P1.2, etc.).
Decoding cellular signals: SMAD signalling and commitment during human embryonic stem cell differentiation
Creators: name: Gunne-Braden, Alexandra
Publisher: name: Imperial College London
Year: 2018

description: During early development, environmental triggers prompt a collection of pluripotent cells to begin the dramatic process of differentiation giving rise to the three germ layers. How and when cells decode information from their environment to bring about commitment is a fundamental, yet unanswered, question. Poised to differentiate, human embryonic stem (hES) cells provide an invaluable model for addressing this question. Bone morphogenic protein 4 (BMP4) triggers hES cell differentiation towards mesoderm, via SMAD signal transduction pathways. In this thesis, we find that commitment to BMP4-driven differentiation is a surprisingly early event. We investigated how BMP4 signals are first decoded by SMAD signalling networks leading to differentiation. Quantitative imaging of SMAD activation in hES cells showed that, in single cells, activation of SMAD1 is ‘switch-like’ and sustained after BMP4 stimulation. We found that SMAD activation is bistable and irreversible, both properties characteristic of signalling networks embedded in positive feedback, and suggest that positive feedback regulation involving expression of the SMAD1 activator, BMPR1A, contributes to the sustained SMAD1 activation. Using a genomics approach, we shed light on gene expression dynamics at the immediate onset of differentiation and reveal that BMP4-induced target genes show distinctive behaviours. We have identified a novel set of SMAD responsive genes, upregulated immediately following commitment, capable of mirroring SMAD activation dynamics with ‘switch-like’, irreversible expression. Focusing on one such gene, GATA3, we find its expression is necessary and sufficient to drive differentiation. We have deemed this novel set of genes early commitment genes (ECGs) and propose that ECG expression provides a crucial link between SMAD activation dynamics and early, irreversible commitment to differentiation. Together these studies shed light on how cells decode signals and irreversibly commit to differentiation, and highlight the usefulness of using hES cells as a model system to understand fate decisions in early development.
Gender Glossary for the REAL DEAL
Creators: name: WECF
Publisher: name: Zenodo
Year: 2023

description: Using a gender glossary is important because language is constantly evolving, and words and phrases that were once considered inclusive may now be considered discriminatory or harmful. This is why it's crucial to stay up-to-date on current language trends and terminology. The glossary also promotes the importance of using language that is progressive and inclusive. When using language, it's important to reflect on mistakes and continuously strive to improve communication in any type of project.

A gender glossary is a valuable tool for promoting understanding and respect among individuals. It can help bridge the gap in language or cultural differences and ensure that all stakeholders are on the same page. This is particularly important in projects that involve a diverse range of individuals and organisations, such as REAL DEAL. By using a gender glossary, individuals can avoid misunderstandings or the use of potentially offensive language, which can lead to unintentional biases or microaggressions that can be hurtful to marginalized individuals.

Overall, using a gender glossary is a critical step towards promoting gender inclusivity and diversity in EU-funded, and any publicly and privately funded, projects. It allows individuals to stay informed and aware of changes in language usage and promotes a better understanding and respect for all individuals, regardless of their gender identity or sexual orientation.

At the REAL DEAL, we have partnered with Women Engage for Common Future (WECF) to develop our own "Gender Glossary". The glossary includes a comprehensive list of concepts from anti-racism to Tokenism to Intersectionality, among others. It also includes recommendations on the preferred language to use when talking about women or people from marginalized groups.
Functional characterisation of interferon stimulated genes in respiratory viral infection
Creators: name: Busse, David C.
Publisher: name: Imperial College London
Year: 2019

description: A key element of host antiviral defence is cell intrinsic immunity, driven by an array of interferon stimulated genes (ISGs), few of which have been properly characterised. However, the breadth of ISG antiviral mechanisms suggests this gene network can target nearly every stage of a viral life cycle. Respiratory syncytial virus (RSV) is responsible for a vast number of infections, primarily in infants. Intriguingly, most infants requiring hospitalisation with a severe RSV infection present with no known risk factor. It was hypothesised that ISGs induced by RSV infection represent potential genetic risk factors that could influence virus control and disease severity between individuals. The IFN-induced transmembrane (IFITM) family of ISGs are broadly antiviral and thought to target virus entry. The data presented here expand our understanding of IFITM1 function by demonstrating that antiviral activity is dependent upon plasma membrane localisation. The in vivo relevance of IFITM1 was also probed in a monogenic knockout mouse model, for the first time demonstrating that the loss of IFITM1 alone is sufficient to result in a loss of viral control and enhanced disease severity. Next, the role of IFN-induced protein 44 (IFI44) proteins was explored as these ISGs are especially poorly characterised and are highly induced by RSV infection. There are conflicting data on the antiviral activity of IFI44 and IFI44L during RSV infection. This study presents evidence that these genes are antiviral, impacting an early point of the viral life cycle associated with reduced polymerase activity. Finally, the loss of IFI44 in vivo was shown to result in increased RSV disease severity.
Theory of material toughness with grain boundary oxide inclusions
Creators: name: Cimbaro, Luca
Publisher: name: Imperial College London
Year: 2019

description: At high temperatures oxygen damages the nickel-based superalloy RR1000, which is used in rotor discs of jet engines, by forming a relatively small oxide inclusion at the tip of an intergranular crack. The inclusion is much more brittle than the surrounding material. Also, it is thickest at the tip of the crack, tapers along the grain boundary over a distance of a few microns, and has a positive misfit. A theory shows that the inclusion enhances the oxidation of the grain boundary ahead of the crack by deriving the hydrostatic stress using functional relationships. The inclusion increases the crack growth by reducing the material toughness of the superalloy. The theory predicts a critical size of the inclusion for the failure of the superalloy. The material toughness of ductile materials such as RR1000 can be orders of magnitudes higher than that of brittle solids. A theory describes the material toughness in crystalline solids from purely brittle to purely ductile behaviour. For shear mode fracture the theory shows that the material toughness is proportional to a critical value of the external stress squared and the length of the crack, whether there is a plastic zone or not. The material toughness is highest in ductile solids because the plastic zone provides additional resistance to crack growth. At the point of crack growth the Peach-Koehler force overcomes the resistance opposing dislocation motion in the plastic zone. An elastic region of variable size, being largest for purely brittle solids and smallest for purely ductile solids, separates the crack tip from the plastic zone. The theory derives a dimensionless variable, which comprises the macroscopic and the microscopic parameters governing the fracture. The dimensionless variable controls the elastoplastic nature of the fracture and determines the size of the elastic region at the crack tip.
Circum-Arctic Lithosphere Evolution (CALE) Transect C: displacement of the Arctic Alaska–Chukotka microplate towards the Pacific during opening of the Amerasia Basin of the Arctic
Creators: name: Miller, Elizabeth L.
name: Meisling, Kristian E.
name: Akinin, Vyacheslav V.
name: Brumley, Kelley
name: Coakley, Bernard J.
name: Gottlieb, Eric S.
name: Hoiland, Carl W.
name: O'Brien, Timothy M.
name: Soboleva, Anna
name: Toro, Jaime
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary material 2 contains previously unpublished geochronologic data on detrital zircon suites and igneous rocks.
Supplementary Material for: Neurodevelopment at 3 Years in Neonates Born by Vaginal Delivery versus Cesarean Section at <26 Weeks of Gestation: Retrospective Analysis of a Nationwide Registry in Japan
Creators: name: Kimura, T.
name: Takeuchi, M.
name: Imai, T.
name: Tanaka, S.
name: Kawakami, K.
name: Neonatal Research Network Of Japan
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: A high proportion of extremely preterm (EPT) infants are born by cesarean section (CS). However, whether the mode of delivery is related to long-term neurodevelopment in these infants is unclear. Objectives: This study aimed to determine whether the mode of delivery is associated with mortality and long-term outcomes in EPT infants. Methods: We analyzed data of the Neonatal Research Network in Japan (NRNJ), a population-based, nationwide registry. Inclusion criteria were neonates who were born between 2003 and 2012 with a gestational age <26 weeks. The primary composite outcome was death before 3 years or neurodevelopmental impairment (NDI) at 3 years. Confounder-adjusted odds ratios (OR) were estimated by logistic generalized linear mixed models, which accounted for clustering within hospitals. Results: 2,138 eligible infants (703 by vaginal delivery [VD] and 1,435 by CS) were identified for primary analysis. The composite outcome of death or NDI was not different between both groups (66.7% by VD and 62.7% by CS, p = 0.075). After multivariate analysis adjusting for confounders, we found that CS did not improve the composite outcome of death or NDI (OR = 0.839, 95% confidence interval = 0.816-1.328, p = 0.742). For secondary outcomes, mortality (OR = 0.824, p = 0.150), NDI (OR = 1.237, p = 0.165), and other neurodevelopmental outcomes were not different between the groups. Conclusions: Among neonates born at <26 weeks, CS does not improve mortality and neurodevelopmental outcomes at 3 years in the NRNJ cohort. However, because of several potential biases such as high rates of infants lost to follow-up, further evidence may be required.
The demographic profile, wellbeing, and motivations of families who home educate in Australia
Creators: name: NICHOLAS LUKE GAMBLE
Publisher: name: Monash University
Year: 2017
Subjects: subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences
subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: Developmental and Educational Psychology

description: This study investigated demographic characteristics, wellbeing, and motivations of 231 parents who home educate their children in Australia and a comparison group of 289 parents who do not. The analyses revealed that parents who home educate reported higher levels of wellbeing and a reduced impact of stress on their wellbeing. The most popular primary motivations were to educate a child without the structure of a school environment, to increase family bonds and to assist a child with an impairment or disability. This study informs policymakers and parents in the area of home education.
experiment data (Apparent shift in long-range motion trajectory by local pattern orientation).zip
Creators: name: Nakayama, Ryohei
name: Harada, Daisuke
name: Kamachi, Miyuki G.
name: Motoyoshi, Isamu
Publisher: name: figshare
Year: 2017
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology

description: _prm.xls: monitor&experiment configuration
exp01: frame duration（50, 100, or 200ms）
exp02: frame number (5, 9, or 24)
exp03: adaptation ※exp03ad.prm is results for non-adaptation condition
exp04: shape orientation test04_01 --> parallel condition test04_02 --> orthogonal condition
Design and Modelling of Robots for Minimally Invasive Surgery
Creators: name: SHAO TONG LIU
Publisher: name: Monash University
Year: 2017
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: The work presented in this thesis focuses on two robots, the remote centre of motion mechanism and the concentric tube robot, respectively. The research outcomes will benefit the development of more capable and dexterous surgical robots and thus promote the application of robotic minimally invasive surgery. A novel remote centre of motion mechanism with reduced footprint is proposed to minimise the chance of collisions between robotic surgical arms. Novel kinetostatic modelling approaches for the concentric tube robots are derived, and the computational efficiencies are evaluated to identify the suitable applications for the individual modelling approaches.
Supplementary Figures and Tables from ABCB transporters in a leaf beetle respond to sequestered plant toxins
Creators: name: Kowalski, Paulina
name: Baum, Michael
name: Körten, Marcel
name: Donath, Alexander
name: Dobler, Susanne
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Phytophagous insects can tolerate and detoxify toxic compounds present in their host plants and have evolved intricate adaptations to this end. Some insects even sequester the toxins for their defence. This necessitates specific mechanisms, especially carrier proteins that regulate uptake and transport to specific storage sites or protect-sensitive tissues from noxious compounds. We identified three ATP-binding cassette subfamily B (ABCB) transporters from the transcriptome of the cardenolide-sequestering leaf beetle Chrysochus auratus and analysed their functional role in the sequestration process. These were heterologously expressed and tested for their ability to interact with various potential substrates: verapamil (standard ABCB substrate), the cardenolides digoxin (commonly used), cymarin (present in the species' host plant) and calotropin (present in the ancestral host plants). Verapamil stimulated all three ABCBs and each was activated by at least one cardenolide, however, they differed as to which they were activated by. While the expression of the most versatile transporter fits with a protective role in the blood–brain–barrier, the one specific for cymarin shows an extreme abundance in the elytra, coinciding with the location of the defensive glands. Our data thus suggest a key role of ABCBs in the transport network needed for cardenolide sequestration.
Wayne Watkins (Full edit)
Creators: name: Bacova, Dr Daniela
name: Telfer, Dr Sarah
Publisher: name: National Teaching Repository
Year: 2022
Subjects: subject: 139999 Education not elsewhere classified
subject: FOS: Educational sciences
subject: 130204 English and Literacy Curriculum and Pedagogy (excl. LOTE, ESL and TESOL)
subject: 130303 Education Assessment and Evaluation

description: This booklet is designed to accompany three different video recordings of microteach lessons delivered by three student teachers who participated in a PGCE programme at the University of Bolton to become qualified teachers in the further education sector in the UK (16+). The microteaches cover the subject areas: ESOL/Literacy; teaching learners with additional needs - autism; and teaching sport. The viewers are encouraged to watch the videos in sections and answer questions that guide their noticing.
The videos aim to encourage viewers to observe particular teaching skills and reflect constructively on the performance of these. Discussions should be about what is expected in the microteach and how to prepare for the task, not about criticism of the student teachers who perform the task. This booklet contains the questions to be answered whilst watching the edited video recordings of the microteach sessions.
Synthesis of incentive structures: input for Participatory Integrated Assessment
Creators: name: Pel, B.
name: Wittmayer, J.M.
name: Geus, T.
name: Oxenaar, S.
name: Avelino, F.
name: Fraaije, M.
name: Petrick, K.
name: Doračić, B.
name: Toporek, M.
name: Brown, D.
name: Campos, I.
name: Gährs, S.
name: Davis, M.
name: Horstink, L.
name: Hinsch, A.
name: Marín-González, E.
name: Ehrtmann, M.,
name: Klarwein, S.
name: Fosse, J.
name: Hall, S.
name: Kampman, B.
Publisher: name: Zenodo
Year: 2020
Subjects: PROSEU
prosumers
incentive
mainstreaming
RES
prosumerism

description: This deliverable develops a comprehensive overview of the incentive structures that shape the mainstreaming of RES prosumerism. The Incentive Structures Framework (ISF) presented here identifies and describes 17 key societal conditions, classified along the three clusters of regulatory-financial conditions, technological-material conditions and cultural-discursive conditions. The relevance is empirically substantiated through brief summaries of observations from PROSEU thematic work packages, Living Labs, and survey results. The ISF also clarifies how these societal conditions can give rise to different forms of RES prosumerism and to tensions and crossroads in the mainstreaming process. The ISF is substantiated through three analyses of political-economical, technological-infrastructural, and organisational crossroads in the mainstreaming process.
description: H2020 project PROSEU - Prosumers for the Energy Union: Mainstreaming active participation of citizens in the energy transition. Work package 6 (WP6) - Participatory Integrated Assessment of Incentive Structures
Learning Curves from Game Data
Creators: name: Stafford, Tom
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Slides for "Beyond the Lab: Using Big Data to Discover Principles of Cognition" Psychonomics Society Workshop at Madison, Wisconsin, 9-12 July 2017

http://www.psychonomic.org/page/2017workshop

Alternative title:
[What I learnt about big data from investigating] Learning Curves in Game Data
International Survey of ALS Experts about Critical Questions for Assessing Patients with ALS
Creators: name: Mamede De Carvalho
name: Ryczkowski, Adam
name: Andersen, Peter
name: Gromicho, Marta
name: Grosskreutz, Julian
name: Kuźma-Kozakiewicz, Magdalena
name: Petri, Susanne
name: Piotrkiewicz, Maria
name: Miltenyi, Gabriel Miltenberger
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Objective: To define an applicable dataset for ALS patient registries we weighted specific clinical items as scored by worldwide ALS experts. Methods: Sixty participants were invited based on relevant clinical work, publications and personal acquaintance. They rated 160 clinical items consensually agreed by the members of our project, incorporating specialists from five European Centres. Scoring scheme was defined as: 1 – essential; 2 – important; 3 – not very important. A mixed effect model was applied to rank items and to find possible correlations with geographical region (Europe vs. outside Europe). Results: We received 40 responses, 20 from Europe and 20 from outside; 42/160 data were scored as essential by >50% of the respondents, including: date of birth, gender, date of disease onset, date of diagnosis, ethnicity, region of onset, predominant upper neuron (UMN) or lower motor neuron (LMN) impairment, proximal versus distal weakness, respiratory symptoms, dysarthria, weight loss, signs of LMN/UMN involvement, emotional incontinence, cognitive changes, respiratory signs, neck weakness, body mass index, ALSFRS-R at entry, ALSFRS-R subscores at entry, timing and pattern of spreading and staging, electromyography, spirometry, MRI, CK level, riluzole intake, genetic background, history of physical exercise and previous and current main occupation. Four components were scored as non-relevant, including place of birth, blood pressure and pain at onset. There was no significant difference between regions (European vs. non-European countries). Conclusions: Our study identified a consensual set of clinical data with 42 specific items that can be used as a minimal data set for patient registers and for clinical trials.
BærUt! Launch Seminar Presentation
Creators: name: Rockenberger, Annika
name: Christensen, Johanne Emilie
Publisher: name: Zenodo
Year: 2024

description: Presentation of BærUt! Sustainable digital scientific editions. Skills hub and network at the University of Oslo, 2024-2026. Content authored by Annika Rockenberger & Johanne Emilie Christensen. Design: Sofie Gilbert.
DT-NeRF: Decomposed Triplane-Hash Neural Radiance Fields for High-Fidelity Talking Portrait Synthesis
Creators: yaoyu su
shaohui wang
haoqian wang
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: In this paper, we present the decomposed triplane-hash neural radiance fields (DT-NeRF), a framework that significantly improves the photorealistic rendering of talking faces and achieves state-of-the-art results on key evaluation datasets. Our architecture decomposes the facial region into two specialized triplanes: one specialized for representing the mouth, and the other for the broader facial features. We introduce audio features as residual terms and integrate them as query vectors into our model through an audio-mouthface transformer. Additionally, our method leverages the capabilities of Neural Radiance Fields (NeRF) to enrich the volumetric representation of the entire face through additive volumetric rendering techniques. Comprehensive experimental evaluations corroborate the effectiveness and superiority of our proposed approach.
Markov chain Monte Carlo methods for Bayesian network inference, with applications in systems biology
Creators: name: SALEM ALI S ALYAMI
Publisher: name: Monash University
Year: 2017
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: 80202 Applied Discrete Mathematics
subject: FOS: Computer and information sciences
subject: 10402 Biostatistics

description: Getting stuck in local maxima is a problem that arises while inferring Bayesian network (BN) structures. This thesis proposes Markov chain Monte Carlo (MCMC) samplers that have been known to substantially resolve this problem but have not been modified to fit simulating BN structures from discrete search spaces. The proposed MCMC samplers are new instances of the Neighbourhood sampler, Hit-and-Run sampler and Metropolis-Hastings sampler. Two adaptive techniques have been also developed to reduce the time-complexity required for inference. A new software has been designed to facilitate using the samplers. The proposed samplers have demonstrated efficient performance in practice.
La rétention et la préparation des enseignants en Alberta : Cadre théorique et étude de cas
Creators: Danielle Dallaire
Publisher: name: University of Alberta Library
Year: 2022

Ce projet présente une investigation exploratoire autour de la rétention d'enseignants gradués de la seule institution postsecondaire francophone à l'Ouest du Canada, située à Edmonton, en Alberta. Elle tente d'identifier et répondre aux raisons derrière la pénurie des enseignants en français en milieu minoritaire.

La première section exploratoire est une analyse de cadre théorique approfondi autour du thème de la rétention. Plusieurs éléments sont abordés tels que comment se définit la rétention d'après les chercheurs, son importance, son lien avec le décrochage de la majorité des nouveaux enseignants millénaires, et le dépannage financier que ça crée aux seins des conseils scolaires. L'institution, tel que le Campus Saint-Jean, joue un rôle important dans la formation des maîtres enseignants. Ce fait ne peut être ignoré, car par la suite ces mêmes enseignants sont responsables de précipité la continuation des programmes minoritaires en français.

La seconde partie tente de tisser des liens entre les théories autour des thèmes de la rétention, et les programmes de formation des maîtres. Le résultat d'une étude de cas, sous forme d'entrevues, auprès de six gradués du Campus Saint-Jean, qui ont quitté au moins une fois le domaine d'enseignant au courant de leur carrière, est abordé afin d'éclairer et mieux identifier ce dont les enseignants ont besoin pour réussir dans des milieux scolaires d'enseignement en français.

Les résultats du projet remettent en question les besoins particuliers des nouveaux enseignants en milieu minoritaire, tout en soulignant l'importance des institutions postsecondaires à maintenir une éducation de qualité courante et efficace qui a comme rôle primordial, la possibilité de résoudre la pénurie canadienne des enseignants en français.
title: Correspondance de Jacques Leibowitch avec Ségolène Guillot (BMS) transférée à plusieurs de ses collègues (Pierre de Truchis, Roland Landman, Eric Caumes, Pierre-Marie Girard, Cynthia Fleury-Perkins)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111132541149
description: created: start=2018-04-27;end=2018-05-03
Asthma medication use among adults with current asthma by work-related asthma status, Asthma Call-back Survey, 29 states, 2012–2013
Creators: name: Dodd, Katelynn E.
name: Mazurek, Jacek M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objective: Asthma severity is defined as the intensity of treatment required to achieve good control of asthma symptoms. Studies have shown that work-related asthma (WRA) can be associated with poorer asthma control and more severe symptoms than non-WRA. Associations between asthma medications and WRA status were assessed using data from the 2012–2013 Asthma Call-back Survey among ever-employed adults (≥18 years) with current asthma from 29 states. Methods: Persons with WRA had been told by a physician that their asthma was work-related. Persons with possible WRA had asthma caused or made worse by their current or previous job, but did not have physician-diagnosed WRA. Asthma medications were classified as controller (i.e., long-acting β-agonist, inhaled corticosteroid, oral corticosteroid, cromolyn/nedocromil, leukotriene pathway inhibitor, methylxanthine, anti-cholinergics) and rescue (i.e., short-acting β-agonist). Demographic and clinical characteristics were examined. Associations between asthma medications and WRA status were assessed using a multivariate logistic regression to calculate adjusted prevalence ratios (PRs). Results: Among an estimated 15 million ever-employed adults with current asthma, 14.7% had WRA and an additional 40.4% had possible WRA. Compared with adults with non-WRA, those with WRA were more likely to have taken anti-cholinergics (PR = 1.80), leukotriene pathway inhibitor (PR = 1.59), and methylxanthine (PR = 4.76), and those with possible WRA were more likely to have taken methylxanthine (PR = 2.85). Conclusions: Results provide additional evidence of a higher proportion of severe asthma among adults with WRA compared to non-WRA. To achieve optimal asthma control, adults with WRA may require additional intervention, such as environmental controls or removal from the workplace exposure.
Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice
Creators: name: Kamagata, Mayo
name: Ikeda, Yuko
name: Sasaki, Hiroyuki
name: Hattori, Yuta
name: Yasuda, Shinnosuke
name: Iwami, Shiho
name: Tsubosaka, Miku
name: Ishikawa, Ryosuke
name: Todoh, Ai
name: Konomi Tamura
name: Tahara, Yu
name: Shibata, Shigenobu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: In mammals, the central clock (the suprachiasmatic nuclei, SCN) is entrained mainly by the light-dark cycle, whereas peripheral clocks in the peripheral tissues are entrained/synchronized by multiple factors, including feeding patterns and endocrine hormones such as glucocorticoids. Clock-mutant mice (Clock/Clock), which have a mutation in a core clock gene, show potent phase resetting in response to light pulses compared with wild-type (WT) mice, owing to the damped and flexible oscillator in the SCN. However, the phase resetting of the peripheral clocks in Clock/Clock mice has not been elucidated. Here, we characterized the peripheral clock gene synchronization in Clock/Clock mice by daily injections of a synthetic glucocorticoid (dexamethasone, DEX) by monitoring in vivo PER2::LUCIFERASE bioluminescence. Compared with WT mice, the Clock/Clock mice showed significantly decreased bioluminescence and peripheral clock rhythms with decreased amplitudes and delayed phases. In addition, the DEX injections increased the amplitudes and advanced the phases. In order to examine the robustness of the internal oscillator, T-cycle experiments involving DEX stimulations with 24- or 30-h intervals were performed. The Clock/Clock mice synchronized to the 30-h T-cycle stimulation, which suggested that the peripheral clocks in the Clock/Clock mice had increased synchronizing ability upon DEX stimulation, to that of circadian and hour-glass type oscillations, because of weak internal clock oscillators.
MPEC 2024-E02 : DAILY ORBIT UPDATE (2024 March 1)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Characteristics of secondhand electronic cigarette aerosols from active human use
Creators: name: Tongke Zhao
name: Nguyen, Charlene
name: Che-Hsuan Lin
name: Middlekauff, Holly R.
name: Peters, Kacey
name: Moheimani, Roya
name: Qiuju Guo
name: Yifang Zhu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The electronic cigarette (EC) is a new source of indoor airborne particles. To better understand the impacts of secondhand vaping (SHV) emissions on indoor air quality, real-time measurements of particle size distribution, particle number concentration (PNC), fine particulate matter (PM2.5), CO2, CO, and formaldehyde were conducted before, during, and after 10 min EC-use among 13 experienced users in an 80 m3 room. To assess particle transport in the room, multiple sampling locations were set up at 0.8, 1.5, 2.0, and 2.5 m away from the subjects. The arithmetic mean (standard deviation) of background PNC and PM2.5 concentrations in the room were 6.39 × 103 (1.58 × 102) particles/cm3 and 8 (1) μg/m3, respectively. At 0.8 m away from EC users, right after initiation of puffing, the PNC and PM2.5 concentrations can reach a peak of ∼105 particles/cm3 and ∼3 × 103 µg/m3, respectively, and then dropped quickly to background levels within 20 s due to dilution and evaporation. At the 0.8 m sampling location, the mean PNC and PM2.5 concentrations during puffing were 2.48 × 104 (2.14 × 104) particles/cm3 and 188 (433) µg/m3, respectively. In addition, two modes of SHV particles were observed at about 15 and 85 nm. Moreover, concentrations of SHV particles were negatively correlated with the distances to EC users. At the 1.5 m location, PNC and PM2.5 levels were 9.91 × 103 (1.76 × 103) particles/cm3 and 19 (14) µg/m3, respectively. Large variations of mean PNC levels exhaled per puff were observed both within and between EC users. Data presented in this study can be used for SHV particle exposure assessment. Copyright © 2017 American Association for Aerosol Research
Conferências, Aulas Abertas, Reuniões Científicas, Workshops, Seminários, Palestras, Jornadas, Exposições e Sessões de Divulgação
Creators: name: Letras, RUA-L Revista Da Universidade De Aveiro
Publisher: name: RUA-L: Revista da Universidade de Aveiro. Letras
Year: 2022

description: Sem resumo disponível.
description: RUA-L: Revista da Universidade de Aveiro. Letras, n.º 10 (2021): Literatura & Cinema
Congressos, Colóquios, Ciclos de Conferências e Seminários Internacionais…
Creators: name: Letras, RUA-L Revista Da Universidade De Aveiro
Publisher: name: RUA-L: Revista da Universidade de Aveiro. Letras
Year: 2022

description: Sem resumo disponível.
description: RUA-L: Revista da Universidade de Aveiro. Letras, n.º 10 (2021): Literatura & Cinema
Provas académicas
Creators: name: Letras, RUA-L Revista Da Universidade De Aveiro
Publisher: name: RUA-L: Revista da Universidade de Aveiro. Letras
Year: 2022

description: Sem resumo disponível.
description: RUA-L: Revista da Universidade de Aveiro. Letras, n.º 10 (2021): Literatura & Cinema