title: Ð¡ÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÑÐºÑÑÑÑ Ð¸ ÐºÐ¸Ð½ÐµÑÐ¸ÐºÐ¸ ÑÐµÐ·Ð¾ÑÐ±ÑÐ¸Ð¸ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Comparative study of the structure and kinetics of resorption of materials based on poly(L-lactide) and poly(Îµ-caprolactone)
Creators: name: ÐÐ°Ð²ÑÐ°Ð¶Ð½ÑÑ, ÐÐ°ÑÐ°Ð»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´)
Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½)
ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¼Ð¸ÐºÑÐ¾Ð²Ð¾Ð»Ð¾ÐºÐ½Ð°
ÑÑÑÑÐºÑÑÑÐ°
ÐºÐ¸Ð½ÐµÑÐ¸ÐºÐ° ÑÐµÐ·Ð¾ÑÐ±ÑÐ¸Ð¸
poly(L-lactide)
poly(Îµ-caprolactone)
electrospinning
microfibers
structure
resorption kinetics

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÑÐºÑÑÑÑ Ð¸ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð², Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð¸Ð· ÑÐ°ÑÑÐ²Ð¾ÑÐ¾Ð² Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°), Ð° ÑÐ°ÐºÐ¶Ðµ ÐºÐ¸Ð½ÐµÑÐ¸ÐºÐµ Ð¸Ñ ÑÐµÐ·Ð¾ÑÐ±ÑÐ¸Ð¸ Ð² Ð¶Ð¸Ð²Ð¾Ð¼ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ðµ Ð´Ð»Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² ÑÐ¾ÑÑÐ´Ð¸ÑÑÐ¾Ð¹ ÑÐ¸ÑÑÑÐ³Ð¸Ð¸. ÐÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ ÑÑÑÐ±ÑÐ°ÑÑÐµ Ð¾Ð±ÑÐ°Ð·ÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¼Ð¸ÐºÑÐ¾- Ð¸ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð¸Ð· Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°), Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÑÐºÑÑÑÑ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐµÐ½ÑÐ³ÐµÐ½Ð¾ÑÑÑÑÐºÑÑÑÐ½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÑÐºÐ°Ð½Ð¸ÑÑÑÑÐµÐ¹ ÐºÐ°Ð»Ð¾ÑÐ¸Ð¼ÐµÑÑÐ¸Ð¸, Ð¾ÑÐµÐ½ÐµÐ½Ñ Ð´ÐµÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÐ½ÑÐµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°. ÐÐ»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ»ÐµÑÐ¾Ðº Ð½Ð° Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð·ÑÐ°Ñ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ in vitro. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ Ð²ÑÑÐ¾ÐºÑÑ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÐºÐ»ÐµÑÐ¾Ðº, Ð¿ÐµÑÐ²Ð¸ÑÐ½Ð¾Ð¹ ÐºÑÐ»ÑÑÑÑÑ Ð´ÐµÑÐ¼Ð°Ð»ÑÐ½ÑÑ ÑÐ¸Ð±ÑÐ¾Ð±Ð»Ð°ÑÑÐ¾Ð² ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°, Ð½Ð° Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð°ÑÑÐ¸Ñ Ð¸Ð· Ð¼Ð¸ÐºÑÐ¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°). Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÑ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ in vivo Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ð»Ð¸ Ð¾ÑÐµÐ½Ð¸ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÑ ÑÐµÐ·Ð¾ÑÐ±ÑÐ¸Ð¸ Ð¿ÑÐ¸ Ð²Ð½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾Ð¼ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð² ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½Ð¾Ðµ ÑÑÑÐ»Ð¾, Ð²Ð½ÑÑÑÐ¸Ð¼ÑÑÐµÑÐ½Ð¾Ð¼ Ð¸ ÑÑÐ±ÑÐ°ÑÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¼. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¾Ð¿ÑÑÐ¾Ð² Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð»Ð¸ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½Ð½ÑÑ Ð¼Ð°ÑÑÐ¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°) Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð±Ð¸Ð¾ÑÐµÐ·Ð¾ÑÐ±Ð¸ÑÑÐµÐ¼ÑÑ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¾Ð² Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ðµ ÑÐµÑÐ´ÐµÑÐ½Ð¾-ÑÐ¾ÑÑÐ´Ð¸ÑÑÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð¼Ð°ÑÑÐ¸ÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¼Ð¸ÐºÑÐ¾- Ð¸ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð¸Ð· Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð¸ Ð¿Ð¾Ð»Ð¸(Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð°), Ð° ÑÐ°ÐºÐ¶Ðµ ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð¼Ð°ÑÑÐ¸ÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÑÐ¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² Ð´Ð»Ñ ÑÐ¾ÑÑÐ´Ð¸ÑÑÐ¾Ð¹ ÑÐ¸ÑÑÑÐ³Ð¸Ð¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸Ñ ÑÑÑÑÐºÑÑÑÑ Ð¸ Ð´ÐµÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÐ½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ².
description: The work is devoted to the study of the structure and properties of materials obtained by electrospinning from solutions of poly(L-lactide) and poly(Îµ-caprolactone), as well as the kinetics of resorption in a living organism for further use in vascular surgery. Tubular samples based on micro- and nanofibers made of poly(L-lactide) and poly(Îµ-caprolactone) were obtained, structural studies were performed using X-ray diffraction analysis and differential scanning calorimetry, and the deformation-strength properties were evaluated. In vitro studies were performed to study the proliferative activity of cells in the obtained samples. The results showed a high proliferative activity of cells, the primary culture of human dermal fibroblasts, on the surface of poly(L-lactide) and poly(Îµ-caprolactone) microfibres. In vivo experiments allowed us to evaluate the processes of resorption with intraperitoneal injection into the bloodstream, intramuscular and subfascial. The results of the experiments demonstrated the positive dynamics of the use of nanofiber matrices based on poly(L-lactide) and poly(Îµ-caprolactone) as bioresorbable implants in the treatment of cardiovascular diseases. Thus, as a result of this work, matrices based on micro- and nanofibers from poly(L-lactide) and poly(Îµ-caprolactone) were obtained, as well as combined matrices based on these polymers for vascular surgery. The study of their structure and deformation-strength properties.