cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Selectins and neutrophil traffic: Margination and Streptococcus pneumoniae-induced emigration in murine lungs
Creators: name: Beaudet, A.L.
name: Mizgerd, J.P.
name: Doerschuk, C.M.
name: Kutkoski, G.J.
name: Meek, B.B.
name: Bullard, D.C.
Publisher: name: Rockefeller University Press
Year: 1996

description: The roles of selectins in the pulmonary margination and emigration of neutrophils were investigated by using mice genetically deficient in both E- and P-selectins (E/P mutants) and/or by intravenous injections of fucoidin (inhibiting both L- and P-selectins). E/P mutants were neutrophilic (14.7 ± 4.9 x 106 vs. 0.8 ± 0.1 x 106 neutrophils/ml). This neutrophilia was associated with increased margination of neutrophils within pulmonary capillaries (39.7 ± 9.4 vs. 4.6 ± 1.1 neutrophil profiles per 100 red blood cells profiles) but no change in margination within noncapillary pulmonary microvessels. After intratracheal instillation of Streptococcus pneumoniae, lungs of E/P mutants displayed increased neutrophil emigration (564 ± 92 vs. 116 ± 19 neutrophils per 100 alveolar profiles), edema (5.3 ± 1.5 vs. 1.5 ± 0.4 μl/g body weight), and histologic evidence of lung injury compared with those in wild type (WT). Fucoidin treatment did not affect neutrophil emigration during streptococcal pneumonia in WT or E/P mice. During pneumonia, the number of white blood cells (WBC) tethered to or spread upon the noncapillary vessel endothelium increased in both WT and E/P lungs. These are the first data demonstrating that neutrophil margination in uninfected pulmonary capillaries does not require E- and P-selectins; that streptococcal pneumonia induces an E- and P-selectin-independent increase in WBC interactions with noncapillary endothelium; and that migration of neutrophils to alveoli can occur despite deficiency or inhibition of all of the known selectins.
Analysis of the Impact of Air Pollutants, PM2.5 and O3, on Life Expectancy and Quality Adjusted Life-Expectancy in Canada
Creators: name: Eshoul, Maysoon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011

description: This thesis analyzes the impact of reducing anthropogenic ozone and fine particulate matter (PM2.5), on mortality rates and incidence of chronic bronchitis (CB) and nonfatal myocardial infarction (AMI). The outcome measures are life expectancy and quality-adjusted life years. The methodologies used include: life tables, discounting, concentration-response function (CRF), quality of life scores and Monte Carlo simulation. The highest estimates of impact due to ozone and PM2.5 across eight Canadian cities are 239 deaths and 3469 life years (95%CI: 3268-3696) and 9032 deaths and 132124 life years (95%CI: 117900-154500) respectively. Impacts on CB and AMI related to elimination in PM2.5 exposure are 3235 cases and 16215 QALYs (95%CI: 12690-23310) and 5204 cases and 6279 QALYs (5436-7816) respectively. The most influential parameters in sensitivity analysis are residual life expectancy, discount rate, CRF, and incidence rates. These findings provide alternative measures to monetary valuation in the analysis of air pollution impacts used by policy makers.
Observational Analysis of Injury in Youth Ice Hockey: Putting Injury into Context
Creators: name: Charles, Boyer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Injury
Bodychecking
Rule changes
Injury reporting

description: This study examines injury in competitive bodychecking and non-body checking youth ice hockey in male and female leagues in Ontario and Quebec. This study consisted of three parts: (1) quantifying the amount of injuries; (2) document situational factors in which hockey injuries occur; (3) observe play and interview parents to understand deeper subjective feelings towards injury and bodychecking. The research utilized a mixed method approach consisting of game observation, postgame injury assessments and semi-structured interviewing with parents. For this thesis, 56 games total were attended and only parents from the bodychecking team were interviewed. All games were video recorded through a dual camera video system. Game footage was then analyzed frame by frame to pinpoint injury locations, points of impact and situational factors surrounding the injury. Field-notes and interviews with parents allowed for a comprehensive look into the feelings and emotions surrounding injury and bodychecking. Results from the research revealed; 1) a disproportionately higher rate of injury in bodychecking hockey comparared to non-bodychecking male and female hockey; 2) an overwhelming percentage of injuries were the result of player and board contact; 3) majority of injuries occurred on legal play; and 4) parents support the concept of delaying bodychecking till later ages.
Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
Creators: name: Beaudet, A.L.
name: Lorenzo, I.
name: Doyle, N.A.
name: Doerschuk, C.M.
name: Bullard, D.C.
name: Kunkel, E.J.
name: Ley, K.
name: Hicks, M.J.
name: Kubo, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: During the initial phase of the inflammatory response, leukocytes marginate and roll along the endothelial surface, a process mediated largely by the selectins and their ligands. Mice with mutations in individual selectins show no spontaneous disease and have mild or negligible deficiencies of inflammatory responses. In contrast, we find that mice with null mutations in both endothelial selectins (P and E) develop a phenotype of leukocyte adhesion deficiency characterized by mucocutaneous infections, plasma cell proliferation, hypergammaglobulinemia, severe deficiencies of leukocyte rolling in cremaster venules with or without addition of TNF-α, and an absence of neutrophil emigration at 4 h in response to intraperitoneal Streptococcus pneumoniae peritonitis. These mice provide strong evidence for the functional importance of selectins in vivo.
An Examination of the Effects of Unmet Psychological Needs on Mental and Physical Health
Creators: name: Beausoleil, Amélie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Psychological Needs
Mental health
Physical health
Need satisfaction

description: The importance of psychological needs for optimal mental and physical well-being has been well documented within the literature. However, there remains little consensus on the definition of basic psychological needs, on which needs are most important or fundamental, and on how to best assess basic needs in individuals. The purpose of this dissertation was to develop and validate a comprehensive measure of fundamental psychological needs and to examine its predictive utility for both mental and physical health. To fulfil these objectives, measure construction and validation studies were conducted in 2 separate undergraduate student samples (N = 226; N = 283). Participants completed online self-report measures of emotional and psychological symptoms, negative life events, personality characteristics, and psychological needs. Factor Analyses of the Psychological Needs Questionnaire (PNQ) revealed that needs can be classified in a three-level multi-factorial confirmatory model and that self-worth and relationship types of psychological needs can be further divided into several, second-level factors. Results also indicated that the PNQ is reliable and possesses good construct validity as well as predictive utility for numerous psychological and physical problems. In addition, psychological needs moderated the relationship between depressive personality characteristics and mood. Future studies should examine the proposed needs-based model in a longitudinal fashion, both in community and clinical samples. In addition to functioning as a global introduction and providing an overview of the relevant literature, Chapter 1 proposes a new model of psychological needs. Chapter 2 describes in further detail the importance of each need identified by the new model, with a particular emphasis on the consequences associated with having each need unfulfilled. Chapter 3, 4, and 5 represent three academic journal articles resulting from the data collected in the current project. Finally, chapter 6 provides a global discussion of the entire dissertation.
Overview of technical approaches to radio frequency interference mitigation
Creators: name: Briggs, F. H.
name: Kocz, J.
Publisher: name: Swinburne
Year: 2024

description: This overview provides an interface between lines of thought on radio frequency interference (RFI) mitigation in the fields of radio astronomy and signal processing. The goal is to explore the commonality of different approaches to help researchers in both fields interpret each other's concepts and jargon. The paper elaborates on the astronomers' concept of gain closure relations and how they may be used in a 'self-calibrating' system of RFI cancellation. Further discussion of the eigen-decomposition method in terms of RFI power and antenna gains introduces adaptive nulling and RFI cancellation through matrix partitioning. While multipath scattering appears at first glance to be fatal to methods of RFI cancellation, its effect is easily incorporated in frequency-dependent gain coefficients under many circumstances.
“Jumping the Fence” - a computer-based educational adventure challenging children to interact with the natural environment through physical exploration and experimentation
Creators: name: Terton, Uwe
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2012
Subjects: ADHD
computer based learning
computers in education
game based learning
situated learning
game design

description: The subject of computer gaming and its associated benefits and problems are of interest to researchers across many different disciplines. The potential benefits of computer games in education, training and entertainment are widely appreciated, but their downside is also equally a matter of concern. Whilst computer games are mostly played for recreational purposes, or to keep the player in suspense, the frequency of game playing and the average duration of the games we now engage in often bring about unintended consequences. On the other hand, not everything about playing computer games is bad. Computer Based Learning (CBL) has great promise as an instructional tool and, whether we like it or not, proficiency with computers has become a key part of the skill set required by modern children and familiarity with interactive technologies is essential for success in contemporary society.
Systematic review and meta-analysis of case-crossover and time-series studies of short term outdoor nitrogen dioxide exposure and ischemic heart disease morbidity
Creators: name: Stieb, David M.
name: Zheng, Carine
name: Salama, Dina
name: BerjawI, Rania
name: Emode, Monica
name: Hocking, Robyn
name: Lyrette, Ninon
name: Matz, Carlyn
name: Lavigne, Eric
name: Shin, Hwashin H.
Publisher: name: BioMed Central
Year: 2020

description: Background: Nitrogen dioxide (NO₂) is a pervasive urban pollutant originating primarily from vehicle emissions. Ischemic heart disease (IHD) is associated with a considerable public health burden worldwide, but whether NO₂ exposure is causally related to IHD morbidity remains in question. Our objective was to determine whether short term exposure to outdoor NO₂ is causally associated with IHD-related morbidity based on a synthesis of findings from case-crossover and time-series studies. Methods: MEDLINE, Embase, CENTRAL, Global Health and Toxline databases were searched using terms developed by a librarian. Screening, data extraction and risk of bias assessment were completed independently by two reviewers. Conflicts between reviewers were resolved through consensus and/or involvement of a third reviewer. Pooling of results across studies was conducted using random effects models, heterogeneity among included studies was assessed using Cochran’s Q and I² measures, and sources of heterogeneity were evaluated using meta-regression. Sensitivity of pooled estimates to individual studies was examined using Leave One Out analysis and publication bias was evaluated using Funnel plots, Begg’s and Egger’s tests, and trim and fill. Results: Thirty-eight case-crossover studies and 48 time-series studies were included in our analysis. NO₂ was significantly associated with IHD morbidity (pooled odds ratio from case-crossover studies: 1.074 95% CI 1.052–1.097; pooled relative risk from time-series studies: 1.022 95% CI 1.016–1.029 per 10 ppb). Pooled estimates for case-crossover studies from Europe and North America were significantly lower than for studies conducted elsewhere. The high degree of heterogeneity among studies was only partially accounted for in meta-regression. There was evidence of publication bias, particularly for case-crossover studies. For both case-crossover and time-series studies, pooled estimates based on multi-pollutant models were smaller than those from single pollutant models, and those based on older populations were larger than those based on younger populations, but these differences were not statistically significant. Conclusions: We concluded that there is a likely causal relationship between short term NO₂ exposure and IHD-related morbidity, but important uncertainties remain, particularly related to the contribution of co-pollutants or other concomitant exposures, and the lack of supporting evidence from toxicological and controlled human studies. An amendment to this paper has been published and can be accessed via the original article. DOI 10.1186/s12940-020-00636-4
The identities of symmetric matrices.
Creators: name: Ma, Wenxin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Mathematics.

description: Let $H\sb{n}$ denote the subspace of symmetric matrices of $M\sb{n},$ the full $n\times n$ matrix algebra with coefficients in a field F. Let $$T\sb{2n}(x\sb1,\...,x\sb{2n-1}; x\sb0)=\sum\limits\sb{\sigma\in S\sb{2n-1}\atop i\equiv 1, 2\ mod\ 4} (-1)\sp{\sigma+i-1}x\sb{\sigma(1)}\cdots \sbsp{x\sb0}{(i)}\cdots x\sb{\sigma(2n-1)},$$and $e(n) = n$ if n is even, n + 1 if n is odd. For all $n\ge 1,\ T\sb{2n}(x\sb1,\...,x\sb{2n-1};\lbrack x\sb{2n},x\sb{2n+1}\rbrack)$ is an identity of $H\sb{n}.$ If $charF \not\vert\ e(n)!,\vert F\vert>2n$ and $n\ne 3,$ then any homogeneous polynomial identity of $H\sb{n}$ of degree 2n + 1 is a consequence of $$T\sb{2n}(x\sb1,\...,x\sb{2n-1}; x\sb{2n}),\ T\sb{2n}(x\sb1,\...,x\sb{2n-1};\lbrack x\sb{2n},x\sb{2n+1}\rbrack)$$by substituting $x\sb{i} \circ x\sb{j}:=x\sb{i}x\sb{j}+x\sb{j}x\sb{i}$ or $x\sb{k}$ for some of their variables or multiplying them by a variable. For n = 3, any identity of $H\sb3$ of degree 7 is a consequence of $$\eqalign{&T\sb6(x\sb1,\...,x\sb5;x\sb6),\ T\sb6(x\sb1,\...,x\sb5;\lbrack x\sb6,x\sb7\rbrack),\cr &Q(x\sb1,\...,x\sb6),\ \lbrack S\sb3(\lbrack x\sb1,x\sb2\rbrack,\lbrack x\sb3,x\sb4\rbrack,\lbrack x\sb5,x\sb6\rbrack),\ x\sb7\rbrack,\cr}$$where $$Q(x\sb1,\...,x\sb6):=\sum\limits\sb{(123),(456)}\ \{\lbrack x\sb1,x\sb2\rbrack\lbrack x\sb3,x\sb4\rbrack\lbrack x\sb5,x\sb6\rbrack\},$$the commutators are the arguments of the triple product $\{abc\}:=abc+cba,$ the sum is taken over cyclic permutations of 1 2 3 and 4 5 6, and $S\sb{n}$ is the standard polynomial. To prove the results, a partial ordering on the homogeneous elements of the free associative algebra F (X) over field F with noncommuting generators $X=\{x\sb1,x\sb2,\...\}$ is defined. Let f be an element of F (X) and n the maximum of the degrees of the variables and the multiplicities of the degrees in f. If f is homogeneous and $charF\ \not\vert\ n!$ then f can be decomposed into a sum of two polynomials $f\sb0$ and $f\sb1$ such that for $0m\le n,\ f\sb0$ is either symmetric or skew-symmetric in all its arguments of degree m according as m is even or odd, and $f\sb1$ is a consequence of polynomials of lower type than f. Osborn's Theorem about the symmetry of the absolutely irreducible polynomial identities is obtained as a corollary. The method we set up here is applicable not only to searching for identities of matrices but also to find the identities of arbitrary algebras.
Supplementary document for Whispering-Gallery Mode InGaN Microdisks on GaN Substrates - 5302403.pdf
Creators: name: Zi, Hui
name: Fu, Wai Yuen
name: Choi, H.
name: Tabataba-Vakili, Farsane
name: Kim-Chauveau, Hyon-ju
name: Frayssinet, Eric
name: DeMierry, Philippe
name: Damilano, Benjamin
name: Duboz, Jean-Yves
name: Boucaud, Philippe
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via α-actinin: Receptor positioning in microvilli does not require interaction with α-actinin
Creators: name: Walker, D.M.
name: Graham, L.
name: Doerschuk, C.M.
name: Pavalko, F.M.
name: Goheen, M.
name: Kansas, G.S.
Publisher: name: Rockefeller University Press
Year: 1995

description: The leukocyte adhesion molecule L-selectin mediates binding to lymph node high endothelial venules (HEV) and contributes to leukocyte rolling on endothelium at sites of inflammation. Previously, it was shown that truncation of the L-selectin cytoplasmic tail by 11 amino acids abolished binding to lymph node HEV and leukocyte rolling in vivo, but the molecular basis for that observation was not determined. This study examined potential interactions between L-selectin and cytoskeletal proteins. We found that the cytoplasmic domain of L-selectin interacts directly with the cytoplasmic actin-binding protein α-actinin and forms a complex with vinculin and possibly talin. Solid phase binding assays using the full-length L-selectin cytoplasmic domain bound to microtiter wells demonstrated direct, specific, and saturable binding of purified α-actinin to L-selectin (K(d) = 550 nM), but no direct binding of purified talin or vinculin. Interestingly, talin potentiated binding of α-actinin to the L-selectin cytoplasmic domain peptide despite the fact that direct binding of talin to L-selectin could not be measured. Vinculin binding to the L-selectin cytoplasmic domain peptide was detectable only in the presence of α-actinin. L-selectin coprecipitated with a complex of cytoskeletal proteins including α-actinin and vinculin from cells transfected with L-selectin, consistent with the possibility that α-actinin binds directly to L-selectin and that vinculin associates by binding to α-actinin in vivo to link actin filaments to the L-selectin cytoplasmic domain. In contrast, a deletion mutant of L-selectin lacking the COOH-terminal 11 amino acids of the cytoplasmic domain failed to coprecipitate with α-actinin or vinculin. Surprisingly, this mutant L- selectin localized normally to the microvillar projections on the cell surface. These data suggest that the COOH-terminal 11 amino acids of the L- selectin cytoplasmic domain are required for mediating interactions with the actin cytoskeleton via a complex of α-actinin and vinculin, but that this portion of the cytoplasmic domain is not necessary for proper localization of L-selectin on the cell surface. Correct L-selectin receptor positioning is therefore insufficient for leukocyte adhesion mediated by L-selectin, suggesting that this adhesion may also require direct interactions with the cytoskeleton.
The Intersection of Narrative and Marketing: Exploring a Video Game Narrative Brand Through Brand Management and Game Studies
Creators: name: Burgess, Jacqueline
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2018
Subjects: game studies
brand management
brand community
brand crisis
narrative brands
qualitative research

description: Although research in Game Studies has been preoccupied with player-centric studies in the last decade, few of these studies have been business-orientated. However, due to the large development costs associated with creating video games, and because the financial success of the video game industry depends on the ability to leverage successful franchises and brands (Alpert, 2007), effective Brand Management, a sub-discipline of Marketing, should be a priority for the industry. Effective brand management results in consumers holding positive thoughts, feelings, and opinions about a brand (Keller, 2013) and therefore should be utilised in player-centric Games Studies research to benefit the industry. This Doctor of Philosophy thesis seeks to address this research gap by interrogating the brand management of a narrative brand-one in which the narrative is a key attribute (Russell & Schau, 2014). Five thematically linked articles to answer two research questions have been produced from this research and provide guidance for the video game industry about the use of branding strategies to fulfil consumer needs. The research undertaken in this doctorate is based in the constructivist paradigm and is interdisciplinary in nature to ensure that video game brands and their consumers are understood both from a Brand Management and a Game Studies point of view. This approach is appropriate because Game Studies is inherently interdisciplinary in nature, with researchers coming from various academic backgrounds (Hjorth, 2011; Shaw, 2010). The data collected were analysed using thematic analysis, an inductive research method used to identify, analyse, and report patterns in data, which are highly flexible and not limited to any particular theoretical framework or discipline (Braun & Clarke, 2006).
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 63 Nr. 3 (2021): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2022

description: Band LXIII (2021), Heft 3
description: Wolfger A. Bulst (1944–2021)...409-411
Domenico Tibaldi critica Palladio: un parere inedito sulla facciata di San Petronio a Bologna...401-408
Michelangelo’s Florentine Patrons, 1501–1502...395-400
Die Kunst der Verkleidung: Giovanni Benedetto Castigliones Jupiter mit den Vögeln als Allegorie der Malerei...377-393
Il testamento di Aurelio Luini e la sua eredità leonardesca (1593)...359-375
¿Flora? de Tiziano. Virtudes y verdadera amistad en el retrato de una reciente esposa...325-357
Il reliquiario con angeli in età gotica: un modello orafo da Parigi all’Italia...295-324
Inhalt | Contenuto
An attempt to isolate nodule-specific cDNA clones from Alnus incana.
Creators: name: Gleeson, Tim.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Molecular.

description: Here we report on the attempt to isolate nodule-specific cDNA clones from a cDNA library that was derived from an actinorhizal species, Alnus incana, nodule poly A+ enriched RNA. mRNA corresponding to these cDNA clones could be detected in RNA isolated from the actinorhizal nodule but, could not be detected in RNA isolated from the root. The pattern of expression of four genes corresponding to the cDNA clones was investigated at various time points following infection. It appears the nodulin clones could be divided into two categories of expression; one showing a maximal expression prior to the onset of nitrogen fixation, and the other expressing a maximal level after the onset of nitrogen fixation. Sequence characterization of these clones eventually revealed that the cDNA clones were ribosomal in nature of both plant and bacterial origin. However, further analysis revealed that one cDNA clone of bacterial origin had a unique 105 bp region. PCR analysis suggests that it may be possible to survey various bacterial species for the presence or absence of this insert in order to classify and investigate the evolution of 23S rRNA within this region of the gene. (Abstract shortened by UMI.)
Developing Secondary English Education Courses for Preservice Teachers Through Practitioner Research
Creators: name: Smith, Carol
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2018
Subjects: English curriculum
pedagogy
relational knowledge
secondary English preservice teachers

description: This thesis presents the findings of an action research study that examined the efficacy of a framework which was developed to deliver a quality secondary English curriculum course for preservice teachers. The framework was developed from the research literature that offered insights into how teaching English in schools, and teacher preparation to do the same, has developed in Australia since the 1960s. Quality English teaching has long been considered important for school students' overall success, with parallels made to the nation's prosperity. Hence, over time, English teacher preparation has been scrutinised in a variety of fields including the media, government, education bodies, the public, and schools. The principal aims of this thesis were, in the first instance, to design and deliver a course of study that was based on research literature recommendations and which withstood the scrutiny of stakeholders. The second, and associated aim, was to explore 'how' to implement the framework within a predetermined time limit. The outcomes of the study will contribute to knowledge about English course/program design and delivery at universities and schools.
Supplementary document for Whispering-Gallery Mode InGaN Microdisks on GaN Substrates - 5302403.pdf
Creators: name: Zi, Hui
name: Fu, Wai Yuen
name: Choi, H.
name: Tabataba-Vakili, Farsane
name: Kim-Chauveau, Hyon-ju
name: Frayssinet, Eric
name: DeMierry, Philippe
name: Damilano, Benjamin
name: Duboz, Jean-Yves
name: Boucaud, Philippe
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1
Towards a Comprehensive Understanding of Women’s Physical Activity Behaviour during Pregnancy and Postpartum: Implications for Intervention Design
Creators: name: Van Mulken, Michelle
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2013
Subjects: pregnancy
postpartum
physical activity
experiences
socio-ecological framework
feminism
Australia

description: Women going through the major life transition of pregnancy and early motherhood may experience significant physical, psychological, social and lifestyle changes, including a decrease in physical activity behaviour, which potentially compromises maternal, infant and family health and wellbeing. Current evidence does not seem to provide a comprehensive understanding of the determinants of women's physical activity behaviour during pregnancy and postpartum and no longitudinal study during this transition phase has been published to date. This PhD therefore explored: life and physical activity changes; individual, social environmental, and physical environmental determinants of physical activity behaviour; and how women give meaning to their physical activity experiences during pregnancy and the postnatal period, including how these meanings relate to or are shaped by dominant ideology around physical activity, pregnancy and motherhood. The findings of this exploration were used to develop intervention suggestions that may improve future intervention design in order to increase physical activity in this particular population. This research project consisted of: 1) a literature review on the determinants of physical activity, 2) an intervention review, and 3) a longitudinal study. The longitudinal study involved four intervals (1st, 2nd, 3rd trimester, and 3 months postpartum) and was subjected to a dual qualitative analysis: socio-ecological and feminist.
P-selectin/ICAM-1 double mutant mice: Acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli
Creators: name: Lorenzo, I.
name: Beaudet, A.L.
name: Bullard, D.C.
name: Doyle, N.A.
name: Vestweber, D.
name: Doerschuk, C.M.
name: Bosse, R.
name: Qin, L.
name: Quinlin, W.M.
Publisher: name: American Society for Clinical Investigation
Year: 1995

description: Neutrophil emigration during an inflammatory response is mediated through interactions between adhesion molecules on endothelial cells and neutrophils. P-Selectin mediates rolling or slowing of neutrophils, while intercellular adhesion molecule-1 (ICAM-1) contributes to the firm adhesion and emigration of neutrophils. Removing the function of either molecule partially prevents neutrophil emigration. To analyze further the role of P-selectin and ICAM-1, we have generated a line of mice with mutations in both of these molecules. While mice with either mutation alone show a 60-70% reduction in acute neutrophil emigration into the peritoneum during Streptococcus pneumoniae- induced peritonitis, double mutant mice show a complete loss of neutrophil emigration. In contrast, neutrophil emigration into the alveolar spaces during acute S. pneumoniae-induced pneumonia is normal in double mutant mice. These data demonstrate organ-specific differences, since emigration into the peritoneum requires both adhesion molecules while emigration into the lung requires neither. In the peritoneum, P-selectin-independent and ICAM-1- independent adhesive mechanisms permit reduced emigration when one of these molecules is deficient, but P-selectin-independent mechanisms cannot lead to ICAM-1-independent firm adhesion and emigration.
Kinome-wide RNAi Screening to Identify Kinases Involved in Post-translational Modification of FUS
Creators: name: Liu, Serena E. B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: FUS
ALS
Kinome-wide RNAI Screen
Post-translational Modification

description: Amyotrophic lateral sclerosis (ALS) is a devastating adult onset neurodegenerative disorder characterized by the selective degeneration of upper and lower motor neurons. Patients typically die from respiratory failures within 2-5 years after diagnosis. One of the milestones in ALS research is the discovery Fused in Sarcoma (FUS), an ALS causative gene. FUS is an RNA/DNA-binding protein and predominantly resides in the nucleus. Majority of the FUS mutations are located in the C-terminus and causing aberrant misdistribution to the cytoplasm. Currently, only a few binding partners of FUS are known, which makes it difficult to speculate on the function and interaction of the protein. In this study, we conducted a kinome-wide RNAi screen to identify kinases that affect the localization of FUS. A dual specificity protein kinase named CDC2-like kinase (CLK1) from the screen was found to be responsible for in post-translational modification of FUS and affects the localization of FUS in the nucleus. The identification of CLK1 as FUSmodifying kinase is consistent with roles ascribed to both in the binding and regulation of RNA.
Supervising international undergraduate medical students
Creators: name: Melles, Gavin
Publisher: name: Swinburne
Year: 2024

description: Research supervision of undergraduate students has been the focus of few studies in the higher education literature. Asian second language students bring linguistic and cultural practices to the supervision process, which have been negatively cast within a discourse of cultural deficit. This interview-based study employing active interview methods and principles of grounded theory for data analysis examines supervisor perceptions of the challenges facing Indonesian students undertaking an MBBS intercalated BMedSci science degree in the Faculty of Medicine, Dentistry and Health Science at Melbourne University. This paper reports qualitative analysis of responses by twenty-seven academic supervisors of the benefits and issues facing Indonesian exchange abroad students in this context.
Lymphocyte accumulation during Pseudomonas aeruginosa-induced pneumonia in rodents does not require CD11a and intercellular adhesion molecule-1.
Creators: name: Sligh, J.E.
name: Quinlan, W.M.
name: Doerschuk, C.M.
name: Doyle, N.A.
name: Wiebke, J.L.
name: Smith, C.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: During Pseudomonas aeruginosa-induced pneumonia in rodents, the acute infiltrate of neutrophils is followed by accumulation of lymphocytes in the perivascular connective tissue. The roles of the adhesion molecules CD11a/CD18 and intercellular adhesion molecule-1 (ICAM-1) in this accumulation of lymphocytes were investigated. The numbers of lymphocytes in P. aeruginosa-induced pneumonia were compared in animals treated with blocking antibodies to either CD11a, ICAM-1, IgG, or no antibody. In other experiments, the lymphocyte accumulation during P. aeruginosa-induced pneumonia in ICAM-1 mutant mice was compared with that in wild-type mice. In rats, both a murine anti-rat CD11a antibody and nonspecific murine IgG partially inhibited the lymphocyte accumulation by 30 to 40% compared with animals that received no antibodies. In mice, blocking antibodies to either CD11a or ICAM-1 did not decrease the lymphocyte accumulation compared with mice given IgG or no antibody. Further, there was no attenuation of the lymphocyte accumulation induced by P. aeruginosa in the ICAM-1 mutant mice compared with wild-type mice, either in the total number of lymphocytes or the number of CD4+, CD8+, or B cells. We conclude that neither CD11a/CD18 nor ICAM-1 are required for lymphocyte accumulation during P. aeruginosa-induced pneumonia in rodents. The partial inhibition of the lymphocyte accumulation in both the anti-CD11a- and IgG-treated rats may be due to nonspecific effects of foreign proteins on cellular functions.
The Political Possibilities of CSR: Mining Company-Community Conflict in Peru
Creators: name: Williams, Zoe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: corporate social responsibility
Peru
Mining
social conflict

description: This paper examines the ways in which corporate social responsibility (CSR) is used by mining companies in Peru to minimize conflict between themselves and communities. It assesses the use of CSR at both the community and national levels, and concludes that there are important limitations to a reliance on the privatized management of social conflict. Most importantly, a reliance on corporations to manage conflict in which they themselves take part inherently limits the outcomes of this conflict for the communities to those which do not threaten the business interests of the companies. This paper further argues that the political organization of communities and the involvement of external actors in the conflict has an effect on the type of CSR policies enacted by the company. Thus, communities who are better organized, especially with the help of external actors, may achieve more favourable results from CSR-led negotiations with companies.
Activation of neutrophils within pulmonary microvessels of rabbits exposed to cigarette smoke.
Creators: name: Doerschuk, C.M.
name: Burns, A.R.
name: Klut, M.E.
name: Van Eeden, S.F.
name: Hogg, J.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood of rabbits because these molecules are known to be upregulated and downregulated, respectively, on the surface of activated PMN. New Zealand white rabbits (3.5 +/- 0.1 kg) were exposed to either air (n = 5) or cigarette smoke (n = 5), and we used an established protocol to measure pulmonary vascular blood flow, volume, and red blood cell (RBC) transit time in the left lung. The right lungs were then fixed in 0.025% glutaraldehyde and stored in liquid nitrogen. Ultrathin sections were immuno-labeled with either the anti-CD18 monoclonal antibody 60.3 or the anti-L-selectin antibody Dreg-200, followed by a secondary antibody conjugated to 10 nm colloidal gold. The target antigens were quantified by counting the number of gold particles per micron (G/microns) of PMN surface membrane. The data show that smoke exposure had no effect on pulmonary blood flow, volume, or RBC transit time. However, it increased the expression of CD11/CD18 on intravascular PMN in the upper region of the lung (control, 7.4 +/- 1.3 G/microns; smoke-exposed, 13.2 +/- 3.3 G/microns; P < 0.05) and decreased the expression of L-selectin on intravascular PMN in both the lower (control, 5.5 +/- 2.0 G/microns; smoke-exposed, 2.6 +/- 1.5 G/microns; P = 0.05) and the upper (control, 6.8 +/- 1.4 G/microns; smoke-exposed, 2.6 +/- 1.2 G/microns; P < 0.05) regions.
Ermittlung des Standes der Technik der Geräuschemissionen europäischer Schienenfahrzeuge und deren Lärmminderungspotenzial mit Darstellung von Best-Practice-Beispielen
Creators: name: Gutmann, Christian
Publisher: name: My University
Year: 2013
Subjects: subject: Stand der Technik
subject: Schallemission
subject: Geräuschemission
subject: Schienenfahrzeug
subject: Lärmminderungspotenzial
subject: Datengewinnung
subject: Grenzwertfestsetzung
subject: noise
subject: rail traffic noise
subject: noise emission
subject: Verkehr
subject: Transport
subject: Lärm

description: Die zahlreichen Lärmminderungstechniken werden im Rahmen einer europaweiten Literaturstudie zusammengestellt und bewertet. Für alle Fahrzeugkategorien bestehen zum Teil erhebliche Lärmminderungspotentiale. Vorschläge für zweistufige Grenzwerte nach dem Stand der Technik werden erarbeitet. Vorbildliche akustische Fahrzeuge werden als Best-Practice Fahrzeuge dargestellt.The present research project deals with the determination of the state-of-the-art for noise emissions from European railway vehicles. Noise emission data were collected and evaluated and the noise mitigation potentials were determined. Best practice vehicles show that significant improvements in noise reduction are possible.
A graphical specification of model transformations with triple graph grammars
Creators: name: Grunske, Lars
name: Geiger, Leif
name: Lawley, Michael
Publisher: name: Swinburne
Year: 2024

description: Models and model transformations are the core concepts of OMG's MDA(tm) approach. Within this approach, most models are derived from the MOF and have a graph-based nature. In contrast, most of the current model transformations are specified textually. To enable a graphical specification of model transformation rules, this paper proposes to use triple graph grammars as declarative specification formalism. These triple graph grammars can be specified within the FUJABA tool and we argue that these rules can be more easily specified and they become more understandable and maintainable. To show the practicability of our approach, we present how to generate Tefkat rules from triple graph grammar rules, which helps to integrate triple graph grammars with a state of a art model transformation tool and shows the expressiveness of the concept.
An Examination of the Accuracy of Nutrient Profiling Models
Creators: name: Cooper, Sheri
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2016
Subjects: nutrition labelling
nutrient profile model
validation
Health Star Rating
accuracy

description: Nutrient profiling is defined by the World Health Organisation as the science of classifying or ranking foods according to their nutritional composition for reasons related to preventing disease and promoting health. Nutrient profiling models are instruments used to rank the nutrient composition of foods and beverages. These models have many applications including: the regulation of nutrition and health claims; the assessment of the eligibility of food marketed to children; to provide the stimulus for food reformulation; and, most commonly, to provide the basis for nutrition signposting schemes which are designed to identify healthier food choices. It is therefore crucial that nutrient profiling models are objectively assessed for accuracy, to ensure that a food identified as a healthier choice is unequivocally associated with preventing disease and promoting health. This thesis aimed to investigate the methods used to validate current nutrient profiling models and to use one of the identified methods to assess the validity of the Australian nutrient profiling models that form the basis of the Health Star Rating system. This research consisted of three studies that used a combination of different research methods to address the overall aims and objectives of this thesis.
The role of CD18-mediated adhesion in neutrophil sequestration induced by infusion of activated plasma in rabbits.
Creators: name: Doerschuk, C.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Infusion of activated plasma induces neutropenia and sequestration of neutrophils within the microvasculature. This study examined the role of the adhesion glycoprotein complex, CD11/CD18, in this sequestration. Rabbits pretreated with either the anti-CD18 monoclonal antibody (mAb) 60.3 or saline were given infusions of zymosan-activated plasma (ZAP) or saline. The effect of mAb 60.3 on the changes in circulating neutrophil counts, radiolabeled neutrophil kinetics in the lung, and the pulmonary microvascular accumulation of neutrophils induced by ZAP infusion was determined. The data show that pretreatment with mAb 60.3 did not inhibit either the rate of onset or the severity of the neutropenia but prevented the sustained neutropenia. In addition, mAb 60.3 completely prevented the ZAP-induced changes in radiolabeled neutrophil kinetics and largely inhibited the accumulation of neutrophils within the capillaries and the small vessels when evaluated after 15 min of ZAP infusion. We conclude that neutrophil accumulation is a two-step process, the first occurring through a CD18-independent mechanism that may involve a stimulus-induced decrease in neutrophil deformability and acts to slow neutrophil transit through the lung. The second step requires CD18-dependent adhesion and is needed for prolonged accumulation of neutrophils within the pulmonary microvasculature.
Partners in Recovery - A Critical Social Perspective on Innovation in Mental Health Service Delivery
Creators: name: Austin, Jenny
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2017
Subjects: public health

description: This thesis offers a critical social perspective on innovation in mental health service provision in Australia. It presents and interrogates the findings of a local evaluation of the Sunshine Coast and Gympie Partners in Recovery (PIR)1 mental health service in order to explore the benefits, limitations, and possible future prospects for community-based and recovery-oriented, mental health service provision.
Human Footpaths in the Outer Suburbs of Ottawa: Distribution, Network Connectivity, and Walkability
Creators: name: Saboui, Karine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Footpaths
Walkability
Network Connectivity

description: This research has three objectives; 1) describe the distribution of footpaths in the outer suburbs of Ottawa, 2) quantify the impact footpaths have on network connectivity in the outer western suburban neighborhoods of Ottawa, 3) quantify the impact of footpaths on destination-based walkability measures in the outer western suburban neighborhoods of Ottawa. The distribution of footpaths is assessed using a principal component analysis on 86 observations (footpaths) and 11 variables (land usage, transit connection, income, population density). Network connectivity is measured using the link-node ratio, the gamma index, and the alpha index, as well a node betweenness centrality. Walkability is measured in ArcGIS through an origin-destination cost matrix. The results show that the distribution of footpaths cannot be explained by the selected variables. Footpaths slightly decrease overall network connectivity and re-work node betweenness centrality. Footpaths have no impact on destination-based walkability. And so, footpaths may serve as better pedestrian routes but not necessarily as faster routes through the outer western suburbs of Ottawa.
Novel Drying Methods for Sustainable Upcycling of Brewers’ Spent Grains as a Plant Protein Source
Creators: name: Pratap-Singh, Anubhav
name: Mandal, Ronit
name: Shojaei, Maryam
name: Singh, Anika
name: Kowalczewski, Przemysław Łukasz
name: Ligaj, Marta
name: Pawlicz, Jarosław
name: Jarzębski, Maciej
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Brewers’ spent grains (BSGs) are the most important by-product of the brewing industry and are rich in protein and fiber. However, abundant amounts of BSGs are discarded annually worldwide. This project aimed to employ and compare innovative drying techniques to introduce snacks with protein sources derived from leftover BSGs. This study explored the dehydration kinetics of BSGs and the effect of three different drying methods—oven drying (OD), freeze drying (FD), and vacuum microwave drying (VMD)—on their protein content and functionality. Then, an energy and exergy analysis for the drying methods was given. Accordingly, a snack product (baked chips) using the dehydrated BSGs was developed by a sensory panel study to assess consumer acceptability of the final products. It was found that the VMD process took less drying time (48 min) compared to OD (50 min), with higher effectiveness as a drying process. VMD-treated BSG also showed moderate protein functionality and the highest overall acceptability when used in baked chips. Thus, VMD might be used as a sustainable drying technology for thermal treatment and valorization of BSG. In addition to having implications for dietary health, findings can help improve the economy of the breweries and other industries that deal with the processing of grains by valorizing their process waste and contributing to sustainability.
Platelet distribution in rabbits following infusion of liposomes
Creators: name: Bally, M.B.
name: Cullis, P.R.
name: Doerschuk, C.M.
name: Gie, R.P.
name: Reinish, L.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: This investigation determined the organ distribution of liposomes containing egg phosphatidylcholine and cholesterol with egg phosphatidylglycerol (PG liposomes) or without (PC liposomes) and the effect of each liposome on platelet distribution in rabbits. Eight minutes after 51chromium-labelled platelets were given intravenously, either saline (n = 7), iodinated PG liposomes (n = 5) or iodinated PC liposomes (n = 5) were infused. Two minutes later the organ distribution of 51Cr-platelets and 125I-liposomes were compared. The PG liposomes produced a 41 ± 5% reduction in circulating platelet counts while PC liposomes did not. The PG liposomes decreased circulating 51Cr-platelets by a factor of 2 and increased platelet recoveries in the liver and lungs. The increased platelet recovery in the liver was associated with a greater PG liposome recovery. When animals receiving PG liposomes were studied over 60 minutes, both the labelled and unlabelled platelet counts returned to control values by 30 minutes and the 51Cr-platelet distribution between organs was similar to control values. These data indicate that platelets and PG liposomes initially sequester together and that this platelet-liposome interaction is specific for PG liposomes. However, the platelet sequestration is transient and by 60 minutes the platelets were released and circulating.