cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development and validation of analytical methods for therapeutic drug monitoring
Creators: name: Pingeon, Marine
Publisher: name: Universita degli studi di Salerno
Year: 2019
Subjects: subject: BIO/10 BIOCHIMICA
subject: HPLC
subject: LC-DS/MS
subject: TDM

description: 2017 - 2018
description: The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in molecular or environmental features and in lifestyles. The major goals of PM are to maximize treatment efficacy and to reduce cost, toxicities and therapy failure rates by early identification of patients who might benefit or not of a specific treatment. In this scenario, therapeutic drug monitoring (TDM) is an important laboratory tool for PM because of the possibility to measure several drugs and bioactive molecules in human biological matrices. TDM is based on the hypothesis that in the majority of drugs, there is a relationship between administered dose and circulating concentration of unbound fraction - and between this concentration and observed pharmacological effects. TDM is recommended for drugs with significant inter-individual pharmacokinetic variability and an established relationship between blood concentrations and clinical efficacy and/or toxicity. Moreover, TDM is also advisable in special populations such as pregnant women and children. To date, liquid chromatography and immunometric assay are still considered the standard for molecule measurement in biological fluids; however, in recent years, LC tandem mass spectrometry (LC-MS) is gaining popularity because of the possibility of in-depth and multiplexed analysis with high selectivity and specificity. During this Ph.D. program, we developed several high performance LC (HPLC)- and LC-MS/MS-based approaches for TDM of different drugs measured in various types of body fluids and validated according to EMA and FDA guidelines. In particular, we focused on: 1) TDM of hydroxychloroquine (HCQ) blood concentration, a drug with a wide therapeutic window. Our method was validated on a cohort of patients with Systemic Lupus Erythematosus treated with HCQ and blood concentrations were correlated to several clinical parameters, such quality of life. Moreover, TDM of HCQ was also used to monitor treatment adherence in those subjects. 2) TDM of a commonly used chemotherapeutic agent, the 5-fluorouracil (5-FU), which is known to have a narrow therapeutic window and a high toxicity 3) TDM of a new kinase inhibitor, Ruxolitinib, approved for the treatment of myeloproliferative hematologic disorders. 4) TDM of several drugs, such as caffeine and phenobarbital, in newborns who are at particular risk of uncorrected drug dosage. Due to the need to carry out analyses on very-small volume samples, we validated an analytical method using micro-sampling techniques such as the dried blood spot (DBS) sampling combined with LC-MS/MS analysis. [edited by author]
Was ist Wissenschaftskommunikation?
Creators: name: Seltmann, Melanie Elisabeth-H.
Publisher: name: Zenodo
Year: 2023
Subjects: Wissenschaftskommunikation
Digital Humanities
DHd-AG
DHd-AG WissKomm
Science Communication
Scholarly Communication

description: Präsentation zur Einführung in die Wissenschaftskommunikation, speziell in den digitalen Geisteswissenschaften. Die Präsentation ist Teil des Workshops "Wissenschaftskommunikation in den Digital Humanities" der DHd-AG digitale Wissenschaftskommunikation und Public Humanities.
Predicting Protein and Pathway Associations for Understudied Dark Kinases using Pattern-constrained Knowledge Graph Embedding
Creators: name: Mariah V. Salcedo 1 +, Nathan Gravel 2 +, Abbas Keshavarzi 3 , Liang-Chin Huang 2 , Krzysztof J. Kochut* 3 , Natarajan Kannan* 1, 2
Publisher: name: Zenodo
Year: 2023

description: Just for the IDG poster Manuscript is "PeerJ-RegPattern2Vec_Jan18-NK .pdf" all other files are figures/tables
Characterizing the heterogeneity of membrane liquid-ordered domains
Creators: name: Sarkar, Tanmoy
name: Farago, Oded
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: We use a lattice model of a ternary mixture containing saturated and unsaturated lipids with cholesterol (Chol), to study the structural properties characterizing the coexistence between the liquid-disordered and liquid-ordered phases. Depending on the affinity of the saturated and unsaturated lipids, the system may exhibit macroscopic (thermodynamic) liquid-liquid phase separation, or be divided into small-size liquid-ordered domains surrounded by a liquid-disordered matrix. In both cases, it is found that the nano-scale structure of the liquid-ordered regions is heterogeneous, and that they are partitioned into Chol-rich sub-domains and Chol-free, gel-like, nano-clusters. This emerges as a characteristic feature of the liquid-ordered state, which helps distinguishing between liquid-ordered domains in a two-phase mixture, and similar-looking domains in a one-phase mixture that are rich in saturated lipids and Chol, but are merely thermal density fluctuations. The nano-structure heterogeneity of the liquid-ordered phase can be detected by suitable experimental spectroscopic methods, and is observed also in atomistic computer simulations.
Exploring the role of the Sun's motion in terrestrial comet impacts
Creators: name: Feng, Fabo
name: Bailer-Jones, C. A. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The cratering record on the Earth and Moon shows that our planet has been exposed to high velocity impacts for much or all of its existence. Some of these craters were produced by the impact of long period comets (LPCs). These probably originated in the Oort cloud, and were put into their present orbits through gravitational perturbations arising from the Galactic tide and stellar encounters, both of which are modulated by the solar motion about the Galaxy. Here we construct dynamicalmodels of these mechanisms in order to predict the time-varying impact rate of LPCs and the angular distribution of their perihelia (which is observed to be non-uniform). Comparing the predictions of these dynamical models with other models, we conclude that cometary impacts induced by the solar motion contribute only a small fraction of terrestrial impact craters over the past 250 Myr. Over this time scale the apparent cratering rate is dominated by a secular increase towards the present, which might be the result of the disruption of a large asteroid. Our dynamical models, together with the solar apex motion, predict a non-uniform angular distribution of the perihelia, without needing to invoke the existence of a massive body in the outer Oort cloud. Our results are reasonably robust to changes in the parameters of the Galaxy model, Oort cloud, and stellar encounters.
description: 22 pages, 8 tables, 20 figures; accepted for publication by MNRAS
A SPHERE Legacy 8 years of Exploration of Planetary Formation & (Proto-)Exoplanets
Creators: name: Chauvin, Gaël
Publisher: name: Zenodo
Year: 2023

description: Since its first light in May 2014, SPHERE very quickly obtained unique performances allowing it to revolutionize our vision about the morphology of young planet-forming disks during or right after the planetary formation phase. Various substructures like large spiral arms, multiple rings, shadows or cavities were spatially resolved and in some cases characterized spectroscopically or polarimetrically. Several sharp, Kuiper-like belts were also imaged. These first studies paved the way toward the first unambiguous discovery of two young proto-planets within a transition disk, and several new exoplanets. In synergy with ALMA, MUSE and GRAVITY, SPHERE observations offer a fabulous way to directly explore the planetary formation and evolution, the atmospheric and orbital properties of young Jupiters, the physics of planetary accretion, the presence and properties of circumplanetary disks, and the global system architecture to study the gas and dust dynamics. These discoveries allow us to simultaneously connect the giant planet physical and orbital properties with the disk morphology, and potentially the inner regions where terrestrial planets might form. They lead also to unprecedented constraints on the atmospheric properties and the demographics of young Jupiters. With this presentation, I will come back on these breakthrough results and their importance to feed today our community and the preparation of the new generation of instruments on the VLT and soon the ELT.
Q Narrative: "Seadale Primary School's Story: Establishing infrastructure for quality research use"
Creators: name: Gleeson, Jo
name: Rickinson, Mark
name: Walsh, Lucas
name: Cutler, Blake
name: Khong, Hang
name: Plant, Bernice
name: Boulet, Mark
name: Hall, Genevieve
Publisher: name: Monash University
Year: 2023
Subjects: Teacher education and professional development of educators
Other education not elsewhere classified
Educational administration, management and leadership

description: Monash Q Project's Q Narratives feature practitioner stories and experiences. This Q Narrative showcases insights from collected survey data and in-depth interviews. It focused on the theme of 'establishing infrastructure for quality research use.'
Paramritodus pistacious Huang & Maldonado Capriles
Creators: name: Yu, Tingting
name: Zhu, Qiuyi
name: Li, Guoqing
name: Zhang, Bin
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Paramritodus
Paramritodus pistacious

description: Paramritodus pistacious Huang & Maldonado Capriles  (Figs 2, 8, 16–25)
Amritodus pistacious Huang & Maldonado Capriles, 1992: 2, fig. 1. Holotype ♂, (NMNS, examined)
Amritodus flavocapitatus Cai & He, Cai et al., 2001: 199, figs 54–61. syn. nov.
Diagnosis. Crown and face (Figs 2, 8) yellowish brown, without black spots. Pronotum, mesoscutum and scutellum (Fig. 2) ocher yellow lacking the black markings.
Pygofer (Fig. 17) with elongate caudal lobe; inner processes short and curved apically, not reaching caudal margin, apex hook-shaped. Aedeagal shaft (Figs 19, 20) with subapex curved dorsally in lateral view, without basal pair of processes; dorsal apodeme poorly developed; gonopore subapical.
Material examined. Holotype ♂, 5 ♀ Paratypes, CHINA, Taiwan Province, Taizhong, 15.vii.1987, coll. C.T. Yang (NMNS); 1 ♂, CHINA, Taiwan Province, Taizhong City, Nantou County, Wushe, 1150 m, 6–11.v.1981, coll. K.S. Lin & S.C. Lin (NMNS); 2 ♂, 3 ♀, Taiwan Province, Taizhong City, Nantou County, Lushan, 1000 m, 27–31.v.1980, coll. K.S. Lin & L.Y. Chou (NMNS); 1 ♂, 3 ♀, Taiwan Province, Taoyuan County, Paling, 800m, 3–5.v.1983, coll. K.C. Chou & C.C. Pan (NMNS); 2 ♂, 3 ♀, Henan Province, Huixian County, 15.vi.2008, coll. Wei Liu (IMNU).
Distribution. China (Taiwan, Henan).
Remarks. We examined the type material and clearly showed that P. flavocapitatus should be considered a junior synonym of P. pistacious. This species can be distinguished from the other species of Paramritodus by the elongate pygofer with short inner process and hook-shaped apex.
description: Published as part of Yu, Tingting, Zhu, Qiuyi, Li, Guoqing & Zhang, Bin, 2024, Review of Chinese species of genus Paramritodus Xue & Zhang (Hemiptera: Cicadellidae) with description of a new species, pp. 583-592 in Zootaxa 5501 (4) on pages 585-586, DOI: 10.11646/zootaxa.5501.4.8, http://zenodo.org/record/13745521
Q Narrative: "Seadale Primary School's Story: Establishing infrastructure for quality research use"
Creators: name: Gleeson, Jo
name: Rickinson, Mark
name: Walsh, Lucas
name: Cutler, Blake
name: Khong, Hang
name: Plant, Bernice
name: Boulet, Mark
name: Hall, Genevieve
Publisher: name: Monash University
Year: 2022
Subjects: Teacher education and professional development of educators
Other education not elsewhere classified
Educational administration, management and leadership

description: Monash Q Project's Q Narratives feature practitioner stories and experiences. This Q Narrative showcases insights from collected survey data and in-depth interviews. It focused on the theme of 'establishing infrastructure for quality research use.'
Slowly rotating neutron and strange stars in $R^2$ gravity
Creators: name: Staykov, Kalin V.
name: Doneva, Daniela D.
name: Yazadjiev, Stoytcho S.
name: Kokkotas, Kostas D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In the present paper we investigate self-consistently slowly rotating neutron and strange stars in R-squared gravity. For this purpose we first derive the equations describing the structure of the slowly rotating compact stars in $f(R)$-gravity and then simultaneously solve the exterior and the interior problem. The structure of the slowly rotating neutron stars is studied for two different hadronic equations of state and a strange matter equation of state. The moment of inertia and its dependence on the stellar mass and the $R$-squared gravity parameter $a$ is also examined in details. We find that the neutron star moment of inertia for large values of the parameter $a$ can be up to $30\%$ larger compared to the corresponding general relativistic models. This is much higher than the change in the maximum mass induced by $R$-squared gravity and is beyond the EOS uncertainty. In this way the future observations of the moment of inertia of compact stars could allow us to distinguish between general relativity and $f(R)$ gravity, and more generally to test the strong field regime of gravity.
description: 9 pages, 4 figures
Motion Planning for Autonomous Ground Vehicles Using Artificial Potential Fields: A Review
Creators: name: Rehman, Aziz ur
name: Tanveer, Ahsan
name: Ashraf, M. Touseef
name: Khan, Umer
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Autonomous ground vehicle systems have found extensive potential and practical applications in the modern world. The development of an autonomous ground vehicle poses a significant challenge, particularly in identifying the best path plan, based on defined performance metrics such as safety margin, shortest time, and energy consumption. Various techniques for motion planning have been proposed by researchers, one of which is the use of artificial potential fields. Several authors in the past two decades have proposed various modified versions of the artificial potential field algorithms. The variations of the traditional APF approach have given an answer to prior shortcomings. This gives potential rise to a strategic survey on the improved versions of this algorithm. This study presents a review of motion planning for autonomous ground vehicles using artificial potential fields. Each article is evaluated based on criteria that involve the environment type, which may be either static or dynamic, the evaluation scenario, which may be real-time or simulated, and the method used for improving the search performance of the algorithm. All the customized designs of planning models are analyzed and evaluated. At the end, the results of the review are discussed, and future works are proposed.
Perspectival Quantum Realism
Creators: name: Dieks, Dennis
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: The theories of pre-quantum physics are standardly seen as representing physical systems and their properties. Quantum mechanics in its standard form is a more problematic case: here, interpretational problems have led to doubts about the tenability of realist views. Thus, QBists and Quantum Pragmatists maintain that quantum mechanics should not be thought of as representing physical systems, but rather as an agent-centered tool for updating beliefs about such systems. It is part and parcel of such views that different agents may have different beliefs and may assign different quantum states. What results is a collection of agent-centered perspectives rather than a unique representation of the physical world. In this paper we argue that the problems identified by QBism and Quantum Pragmatism do not necessitate abandoning the ideal of representing the physical world. We can avail ourselves of the same puzzle-solving strategies as employed by QBists and pragmatists by adopting a \emph{perspectival quantum realism}. According to this perspectivalism (close to the relational interpretation of quantum mechanics) objects may possess different, but equally objective properties with respect to different physically defined perspectives. We discuss two options for such a perspectivalism, a local and a nonlocal one, and apply them to Wigner's friend and EPR scenarios. Finally, we connect quantum perspectivalism to the recently proposed philosophical position of \emph{fragmentalism}.
Corporate Profiling: Text Analytics for Employability Skills Mining
Creators: name: Smaldone, Francesco
Publisher: name: Universita degli studi di Salerno
Year: 2021
Subjects: subject: SECS-P/08 ECONOMIA E GESTIONE DELLE IMPRESE
subject: Big data analytics
subject: Corporate profiling
subject: Text mining

description: 2019 - 2020
description: In the current scenario, the increasing attention to big data realities is causing firms to develop new tools for corporate management, touching several realities from the marketing compart to the HR management. In the context of today’s rapid technological development and its application in a growing array of fields, the role of big data is simultaneously evolving. The present doctoral thesis provides insights into the current expectations of employers seeking to hire individuals. Profiling was conducted by harvesting relevant data from job ads published in a US employment website, which currently attracts the US market's highest recruitment traffic. This research aims to identify the skills, experience, and qualifications sought by employers in several industries and for several professionals, also indicating to candidates the tangible parameters that would increase their employability in such a role. [edited by Author]
description: Nello scenario attuale, la crescent attenzione alle realtà di big data sta spingendo le aziende a sviluppare nuovi strumenti per la gestione aziendale, toccando diverse realtà dal comparto marketing alla gestione delle risorse umane. Nel contesto attuale, i repentini cambiamenti di mercato e lo sviluppo tecnologico e le sue applicazioni in una crescent rosa di settori, il ruolo dei big data sta evolvendo simultaneamente. La presente tesi di dottorato fornisce degli insight rispetto alle attuali aspettative dei datori di lavoro che cercano di assumere nuovi lavoratori. Le attività di profilazione sono state condotte tramite lo scraping di annunci di lavoro nel mercato americano, poiché questo è il mercato a più alto traffico di assunzioni. La ricerca è volta ad identificare le competenze, l’esperienza e le qualificazioni che sono ricercate dai datori di lavoro in diversi settori e per diverse offerte di lavoro, anche al fine di indicare ai candidate dei parametri tangibili per accrescere la propria employability rispetto alla propria professione. [a cura dell'Autore]
FlowDNS: Correlating Netflow and DNS Streams at Scale
Creators: name: Maghsoudlou, Aniss
name: Gasser, Oliver
name: Poese, Ingmar
name: Feldmann, Anja
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Knowing customer's interests, e.g. which Video-On-Demand (VoD) or Social Network services they are using, helps telecommunication companies with better network planning to enhance the performance exactly where the customer's interests lie, and also offer the customers relevant commercial packages. However, with the increasing deployment of CDNs by different services, identification, and attribution of the traffic on network-layer information alone becomes a challenge: If multiple services are using the same CDN provider, they cannot be easily distinguished based on IP prefixes alone. Therefore, it is crucial to go beyond pure network-layer information for traffic attribution. In this work, we leverage real-time DNS responses gathered by the clients' default DNS resolvers. Having these DNS responses and correlating them with network-layer headers, we are able to translate CDN-hosted domains to the actual services they belong to. We design a correlation system for this purpose and deploy it at a large European ISP. With our system, we can correlate an average of 81.7% of the traffic with the corresponding services, without any loss on our live data streams. Our correlation results also show that 0.5% of the daily traffic contains malformatted, spamming, or phishing domain names. Moreover, ISPs can correlate the results with their BGP information to find more details about the origin and destination of the traffic. We plan to publish our correlation software for other researchers or network operators to use.
Mode pairs in $\mathcal{PT}$-symmetric multimode waveguides
Creators: name: Huang, Changming
name: Ye, Fangwei
name: Chen, Xianfeng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We study mode properties in multimode optical waveguides with parity-time($\mathcal{PT}$) symmetry. We find that two guiding modes with successive orders 2\emph{m}-1 and 2\emph{m} form a mode pair in the sense that the two components of the pair evolve into the same mode when the loss and gain coefficient increases to some critical values, and they experience $\mathcal{PT}$ symmetry breaking simultaneously. For waveguides that in their conservative limit support an odd number of guiding modes, a new mode with a proper order emerges upon the increase of the gain/loss level, so that it pairs with the already existing highest-order mode and then break their $\mathcal{PT}$ symmetry simultaneously. Depending on the specific realizations of $\mathcal{PT}$-symmetric potentials, higher-order mode pair may experience symmetry breaking earlier or later than the lower-order mode pairs do.
description: 6 pages, 7 figures, to appear in Phys. Rev. A
Inherent limits on optimization and discovery in physical systems
Creators: name: Mlinar, Vladan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Topological mapping of a large physical system on a graph, and its decomposition using universal measures is proposed. We find inherent limits to the potential for optimization of a given system and its approximate representations by motifs, and the ability to reconstruct the full system given approximate representations. The approximate representation of the system most suited for optimization may be different from that which most accurately describes the full system.
Open Access: some practical considerations from the EINITE and SMITE projects
Creators: name: Professor Guido Alfani
Publisher: name: Zenodo
Year: 2022

description: This presentation is from the CIVICA Research Open Science for the Social Sciences workshop on Open Science in Horizon Europe: how and (mostly) why. New rules apply in Horizon Europe which seek to open up every step of the research process according to the principle "as open as possible, as closed as necessary". Is it only a constraint? The umpteenth administrative burden? Or, both a fair principle, as publicly funded research ought to be publicly available, and a powerful leverage for a more transparent and effective science as COVID-19 clearly showed? In this workshop Dr Elena Giglia (Turin University) set out the reasons, tools and rules to practice Open Science in the daily research workflow. In the second part of the workshop, Professor Guido Alfani and Professor Dirk Hovy, both from Bocconi University, then discussed the practice of Open Science from research experience drawn from their own ERC projects.
 Please visit the CIVICA Research Open Science Youtube channel to view this presentation on Open Science in Horizon Europe: how and (mostly) why.
A Randomised Subspace Gauss-Newton Method for Nonlinear Least-Squares
Creators: name: Cartis, Coralia
name: Fowkes, Jaroslav
name: Shao, Zhen
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: Machine Learning (cs.LG)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We propose a Randomised Subspace Gauss-Newton (R-SGN) algorithm for solving nonlinear least-squares optimization problems, that uses a sketched Jacobian of the residual in the variable domain and solves a reduced linear least-squares on each iteration. A sublinear global rate of convergence result is presented for a trust-region variant of R-SGN, with high probability, which matches deterministic counterpart results in the order of the accuracy tolerance. Promising preliminary numerical results are presented for R-SGN on logistic regression and on nonlinear regression problems from the CUTEst collection.
description: This work first appears in Thirty-seventh International Conference on Machine Learning, 2020, in Workshop on Beyond First Order Methods in ML Systems. https://sites.google.com/view/optml-icml2020/accepted-papers?authuser=0. arXiv admin note: text overlap with arXiv:2206.03371
High Connectivity with Minimum BER in Wireless Sensor Networks
Creators: name: Tawfik, Benbella S.
name: Amal, Mohamed
Publisher: name: figshare
Year: 2022
Subjects: subject: 80503 Networking and Communications
subject: FOS: Computer and information sciences
subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 170201 Computer Perception, Memory and Attention
subject: 80104 Computer Vision
subject: Computer Engineering
subject: Computer Software
subject: Applied Computer Science
subject: Theoretical Computer Science

description: Power saving is considered a significant issue relating to
 wireless ad hoc and sensor networks, where nodes normally use limited battery power. Transmitting using unnecessary high power introduces excessive interference. It is much better if the network designer would have each node transmit at the lowest possible power while the network connectivity is preserved.
 This paper introduces the optimal common transmit power,
 defined as the minimum transmit power used by all nodes necessary to guarantee network connectivity. This is desirable in sensor networks since nodes are relatively simple, while modifying transmit power after deployment is difficult.
 The optimal transmit power used in this paper has been derived in previous work. It is subject to the specific routing and medium access control (MAC) protocols considered. However, the approach can be additionally extended to other outing and MAC protocols. In this paper, connectivity is defined in terms of a quality of service (QoS) constraint given by the maximum tolerable bit error rate (BER) at the end of a multihop route with an average number of hops.
Open Access: some practical considerations from the EINITE and SMITE projects
Creators: name: Professor Guido Alfani
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Horizon Europe
Research funding
Research workflow

description: This presentation is from the CIVICA Research Open Science for the Social Sciences workshop on Open Science in Horizon Europe: how and (mostly) why. New rules apply in Horizon Europe which seek to open up every step of the research process according to the principle "as open as possible, as closed as necessary". Is it only a constraint? The umpteenth administrative burden? Or, both a fair principle, as publicly funded research ought to be publicly available, and a powerful leverage for a more transparent and effective science as COVID-19 clearly showed? In this workshop Dr Elena Giglia (University of Turin) set out the reasons, tools and rules to practice Open Science in the daily research workflow. In the second part of the workshop, Professor Guido Alfani and Professor Dirk Hovy, both from Bocconi University, then discussed the practice of Open Science from research experience drawn from their own ERC projects.
Teleparallel Robertson-Walker geometries and applications
Creators: name: Coley, Alan A.
name: Landry, Alexandre
name: Gholami, Fateme
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In teleparallel geometries the coframe and corresponding spin-connection are the principal geometric objects and consequently the appropriate definition of a symmetry is that of an affine symmetry. The set of invariant coframes and their corresponding spin connections that respect the full six dimensional Lie algebra of Robertson-Walker affine symmetries are displayed and discussed. We will refer to such geometries as teleparallel Robertson-Walker (TRW) geometries, where the corresponding derived metric is of Robertson-Walker form and is characterized by the parameter $k = (-1,0,1)$. The field equations are explicitly presented for the $F(T)$ class of teleparallel TRW spacetimes. We are primarily interested in investigating the $k \neq 0$ TRW models. After first studying the $k=0$ models and, in particular, writing their governing field equations in an appropriate form, we then study their late time stability with respect to perturbations in $k$ in both the cases of a vanishing and non-vanishing effective cosmological constant term. As an illustration we consider both quadratic $F(T)$ theories and power-law solutions.
description: 18 pages, no figure, Published in Universe MDPI
Comparison of markers’ effort in providing of feedback via either a rubric or a grade category rating scale (GCRS)
Creators: name: Aucote, Helen
name: Ferrari, Madeleine
name: Mallan, Kimberley Margaret
Publisher: name: Australian Catholic University
Year: 2022
Subjects: Higher education
Feedback
Rubric
Assessment
Marking
Feedback comments

description: The study examines the amount of effort required by the markers when providing feedback on assignments via either a rubric or a graded category rating scale (GCRS). Marking effort was operationalised in terms of the amount of feedback provided. The data collected was: 1) Number of novel comments (comments written specifically for students and inserted into a specific place in the assignment), 2) the total word count of the novel comments, 3) word count of overall comments (summary comments that are not attached to a specific point in the assignment), and 4) number of pre-prepared comment (comments that are pre-prepared and then inserted into specific places in the assignment). The data was collected from 60 randomly selected assignments marked with a rubric and 60 randomly selected assignments marked with a GCRS.
description: Survey
description: SPSS
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Creators: name: Sonousi, Amr
name: Hassan, Rasha A.
name: Osman, Eman O.
name: Abdou, Amr M.
name: Emam, Soha H.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Nineteen new quinazolin-4(3H)-one derivatives 3a–g and 6a–l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent compound 6d displayed superior sub-micromolar antiproliferative activity towards NSC lung cancer cell line NCI-H460 with GI50 = 0.789 µM. It also showed potent cytostatic activity against 40 different cancer cell lines (TGI range: 2.59–9.55 µM). Compound 6d potently inhibited EGFR with IC50 = 0.069 ± 0.004 µM in comparison to erlotinib with IC50 value of 0.045 ± 0.003 µM. Compound 6d showed 16.74-fold increase in total apoptosis and caused cell cycle arrest at G1/S phase in breast cancer HS 578T cell line. Moreover, the most potent derivatives were docked into the EGFR active site to determine their binding mode and confirm their ability to satisfy the pharmacophoric features required for EGFR inhibition.
Constrained geometric dynamics of the Fenna-Matthews-Olson complex: The role of correlated motion in reducing uncertainty in excitation energy transfer
Creators: name: Fokas, Alexander S.
name: Cole, Daniel J.
name: Chin, Alex W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biomolecules (q-bio.BM)
subject: Other Condensed Matter (cond-mat.other)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The Fenna Mathews Olson (FMO) complex of green sulphur bacteria is an example of a photosynthetic pigment protein complex, in which the electronic properties of the pigments are modified by the protein environment to promote efficient excitonic energy transfer from antenna complexes to the reaction centres. Many of the electronic properties of the FMO complex can be extracted from knowledge of the static crystal structure. However, the recent observation and analysis of long lasting quantum dynamics in the FMO complex point to protein dynamics as a key factor in protecting and generating quantum coherence under laboratory conditions. While fast inter and intra molecular vibrations have been investigated extensively, the slow dynamics which effectively determine the optical inhomogeneous broadening of experimental ensembles has received less attention. Our study employs constrained geometric dynamics to study the flexibility in the protein network by efficiently generating the accessible conformational states from the published crystal structure. Statistical and principle component analysis reveal highly correlated low frequency motions between functionally relevant elements, including strong correlations between pigments that are excitonically coupled. Our analysis reveals a hierarchy of structural interactions which enforce these correlated motions, from the level of monomer monomer interfaces right down to the alpha helices, beta sheets and pigments. In addition to inducing strong spatial correlations across the conformational ensemble, we find that the overall rigidity of the FMO complex is exceptionally high. We suggest that these observations support the idea of highly correlated inhomogeneous disorder of the electronic excited states, which is further supported by the remarkably low variance of the excitonic couplings of the conformational ensemble.
Okoye et al - Comunicar 63 (2020-2) Manuscript Submission - Table I
Creators: name: Okoye, Kingsley
name: Arona-Palacios, Arturo
name: Camacho-Zuñiga, Claudia
name: Hammout, Nisrine
name: Luttmann Nakamura, Emilia
name: Hosseini, Samira
Publisher: name: figshare
Year: 2019
Subjects: Communication technology and digital media studies
Communication studies
Computational linguistics
Stylistics and textual analysis
Organisational, interpersonal and intercultural communication
Multicultural, intercultural and cross-cultural studies
Gender, sexuality and education
Comparative language studies
Applied linguistics and educational linguistics

description: The work implements the Educational Process and Data Mining (EPDM) model on the ECOA SET data by determining the frequency of the top 20 qualities that the students perceive as important in the evaluation of the teachers' performance in the data (ECOA). Technically, the sets of qualities were analyzed in terms of the Male and Female teachers by determining the clustering of words, frequencies, and correlation of the different words. In other word, whereas, the word frequencies are represented according to the highest to the lowest appearing words, the correlation of the words were determined by measuring the probability scales from 0 to 1 values (where: 0 represents 0% and 1 represents 100% likelihood of the students using the associated words in the data). Consequently, the results of the method are as presented in the following Table I.
Stellar multipilicity in the σ Orionis cluster: a review
Creators: name: Caballero, Jose A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The nearby, young, extinction-free σ Orionis cluster is acknowledged as a cornerstone for studying the stellar and substellar formation and evolution, especially at very low masses. However, the relatively limited knowledge of multiplicity in the cluster is dispersed among numerous papers and proceedings with very different aims and, therefore, is difficult to apprehend even for researchers in the subject. Here, I review comprehensively the sexdecuple system σ Ori in the central arcminute, and all close (rho = 0.4-4 arcsec) and wide (rho > 4 arcsec) binaries, triples, hierarchical multiples, and spectroscopic binaries in the cluster that have been reported in the literature until 2014. I conclude with a brief enumeratation of the next steps that should be taken in the near future for having a clear picture of the multiplicity in the σ Orionis cluster.
description: To appear in The Observatory, Oct 2014
SDU-Galaxy / FysikLab: Få exoplaneter ind i skoleklassen
Creators: name: Hinse, Tobias Cornelius
Publisher: name: Zenodo
Year: 2024

description: Besøg af lærerstuderende og Dr. Magdalena Kersting fra Inst. f. Naturfagenes Didaktik / KU. Project-based learning activities in the field of astronomy & exoplanets.
The Bessel zeta function
Creators: name: Naber, M. G.
name: Bruck, B. M.
name: Costello, S. E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 37c30

description: Two representations of the Bessel zeta function are investigated. An incomplete representation is constructed using contour integration and an integral representation due to Hawkins is fully evaluated (analytically continued) to produce two infinite series. This new representation, evaluated at integer values of the argument, produces results that are consistent with known results (values, slope, and pole structure). Not surprisingly, the two representations studied are found to have similar coefficients but a slightly different functional form. A representation of the Riemann zeta function is obtained by allowing the order of the Bessel function to go to 1/2.
Necessary integrability conditions for evolutionary lattice equations
Creators: name: Adler, V. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 37K10

description: The structure of solutions is studied for the Lax equation $D_t(G)=[F,G]$ for formal power series with respect to the shift operator. It is proved that if the equation with a given series $F$ of degree $m$ admits a solution $G$ of degree $k$ then it admits, as well, a solution $H$ of degree $m$ such that $H^k=G^m$. This property is used for derivation of necessary integrability conditions for scalar evolutionary lattices.
description: 23 pp
Intrusion Detection Model Using Naive Bayes and Deep Learning Technique
Creators: name: Abdallah, Mohamed
name: Tawfik, Benbella S.
Publisher: name: figshare
Year: 2022
Subjects: subject: 100507 Optical Networks and Systems
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 100503 Computer Communications Networks
subject: 170205 Neurocognitive Patterns and Neural Networks
subject: FOS: Psychology
subject: Theoretical Computer Science
subject: Applied Computer Science
subject: Information Systems
subject: FOS: Computer and information sciences

description: The increase of security threats and hacking the computer networks are one of the most dangerous issues should treat in these days. Intrusion Detection Systems (IDSs), are the most appropriate methods to prevent and detect the attacks of networks and computer systems. This study presents several techniques to discover network anomalies using data mining tasks, Machine learning technology and dependence of artificial intelligence techniques. In this research, the smart hybrid model was developed to explore any penetrations inside the network. The model divides into two basic stages. The first stage includes the Genetic Algorithm (GA) in selecting the characteristics with depends on a process of extracting, Discretize And dimensionality reduction through Proportional K-Interval Discretization (PKID) and Fisher Linear Discriminant Analysis (FLDA) on respectively. At the end of the first stage combining Naïve Bayes classifier (NB) and Decision Table (DT) using NSL-KDD data set divided into two separate groups for training and testing. The second stage completely depends on the first stage outputs (predicted class) and reclassified with multilayer perceptrons using Deep Learning4J (DL) and the use of algorithm Stochastic Gradient Descent (SGD). In order to improve the performance in terms of the accuracy in classification of penetrations, raising the average of discovering and reducing the false alarms. The comparison of the proposed model and conventional models show the superiority of the proposed model and the previous conventional hybrid models. The result of the proposed model is 99.9325 of classification accuracy, the rate of detection is 99.9738 and 0.00093 of false alarms.
Model Predictive Control Design To Regulate Thyroid Stimulating Hormone Levels In Patients With Hypothyroidism
Creators: name: Srinivasan, Vittal
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 400705
subject: Control engineering
classificationCode: 410302
subject: Biological control

description: This thesis aims to design a controller to apply medication to patients with hypothyroidism, a disease that occurs due to the underacting thyroid gland. The body cannot produce sufficient thyroid hormones, which leads to an increase in the production of hormones in the pituitary gland. The thyroid malfunctioning could lead to other associated conditions like nausea, fatigue, heart conditions, higher cholesterol, and elevated blood pressure. Thus, it is essential to ensure that the levels of thyroid hormones, Triiodothyronine (T3) and Thyroxine (T4), are healthy. The production of these hormones is governed by the hypothalamus-pituitary-thyroid (HPT) axis, a part of the endocrine system. This illness cannot be cured but can be regulated entirely through medication. The standard practice to control hypothyroidism in patients is to prescribe a constant daily dosage of synthetic T4 (i.e., levothyroxine) and, in some cases, an additional dose of synthetic T3 (i.e., Liothyronine). In this thesis, simulation studies are performed where two patients with varying levels of hypothyroidism are prescribed constant doses of synthetic hormones. The medications initially help the patients but are unsuccessful in maintaining healthy ranges. Using model predictive control, an observer-controller-based compensator is proposed to prescribe varying medication doses as inputs based on the patient's requirement. The inputs are quantized to be practically implemented in a real patient scenario. This compensator successfully improves the patient's hormone levels toward healthy values and ensures that the hormone trajectories follow the body's circadian rhythm.
Urban wireless traffic evolution: the role of new devices and the effect of policy
Creators: name: Benseny, Jaume
name: Lahteenmaki, Jarno
name: Toyli, Juuso
name: Hammainen, Heikki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: General Economics (econ.GN)
subject: FOS: Computer and information sciences
subject: FOS: Economics and business

description: The emergence of new wireless technologies, such as the Internet of Things, allows digitalizing new and diverse urban activities. Thus, wireless traffic grows in volume and complexity, making prediction, investment planning, and regulation increasingly difficult. This article characterizes urban wireless traffic evolution, supporting operators to drive mobile network evolution and policymakers to increase national and local competitiveness. We propose a holistic method that widens previous research scope, including new devices and the effect of policy from multiple government levels. We provide an analytical formulation that combines existing complementary methods on traffic evolution research and diverse data sources. Results for a centric area of Helsinki during 2020-2030 indicate that daily volumes increase, albeit a surprisingly large part of the traffic continues to be generated by smartphones. Machine traffic gains importance, driven by surveillance video cameras and connected cars. While camera traffic is sensitive to law enforcement policies and data regulation, car traffic is less affected by transport electrification policy. High-priority traffic remains small, even under encouraging autonomous vehicle policies. We suggest that 5G small cells might be needed around 2025, albeit the utilization of novel radio technology and additional mid-band spectrum could delay this need until 2029. We argue that mobile network operators inevitably need to cooperate in constructing a single, shared small cell network to mitigate the high deployment costs of massively deploying small cells. We also provide guidance to local and national policymakers for IoT-enabled competitive gains via the mitigation of five bottlenecks. For example, local monopolies for mmWave connectivity should be facilitated on space-limited urban furniture or risk an eventual capacity crunch, slowing down digitalization.
Violation of the Einstein's Equivalence Principle for a Composite Quantum Body
Creators: name: Lebed, Andrei G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Recently, we have started to investigate behavior of a composite quantum body in an external gravitational field in the framework of General Relativity [see, for a review, A. G. Lebed, Mod. Phys. Lett. A, {\bf 35}, 2030010 (2020)]. As the simplest example, we have considered a hydrogen atom in a weak gravitational field. Our results are the following. The Einstein's Equivalence Principle survives for the most of macroscopic ensembles of the atoms, containing the stationary quantum states. On the other hand, we have demonstrated that this principle is sometimes broken. In particular, it is broken for the so-called Gravitational demons, which are the coherent macroscopic ensembles of two or more stationary quantum states in the hydrogen atoms. In the above cited paper we have considered the Gedanken experiment, where the gravitational field is suddenly switched on in a free from gravitation space. In the current paper we consider the much more realistic from experimental point of view Gedanken experiment and come to the same conclusion about violations of the Einstein's Equivalence Principle for the Gravitational demons.
description: 4 pages