cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides
Creators: name: Watkins, R.R.
name: Bowers, A.A.
name: Brustad, E.M.
name: Bogart, J.W.
name: Wever, W.J.
name: Gober, J.G.
name: Ghodge, S.V.
Publisher: name: American Chemical Society
Year: 2017

description: Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Many biosynthetic enzymes for RiPPs, especially thiopeptides, are promiscuous and can accept a wide range of peptide substrates with different amino acid sequences; thus, these enzymes have been used as tools to generate new natural product derivatives. Here, we explore an alternative route to molecular complexity by engineering thiopeptide tailoring enzymes to do new or non-native chemistry. We explore cytochrome P450 enzymes as biocatalysts for cyclopropanation of dehydroalanines, chemical motifs found widely in thiopeptides and other RiPP-based natural products. We find that P450TbtJ1 and P450TbtJ2 selectively cyclopropanate dehydroalanines in a number of complex thiopeptide-based substrates and convert them into 1-amino-2-cyclopropane carboxylic acids (ACCAs), which are important pharmacophores. This chemistry takes advantage of the innate affinity of these biosynthetic enzymes for their substrates and enables incorporation of new pharmacophores into thiopeptide architectures. This work also presents a strategy for diversification of natural products through rationally repurposing biosynthetic enzymes as non-natural biocatalysts.
(502336) James Gray
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Gravitational Waves From a Dark (Twin) Phase Transition
Creators: name: Schwaller, Pedro
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this work, we show that a large class of models with a composite dark sector undergo a strong first order phase transition in the early universe, which could lead to a detectable gravitational wave signal. We summarise the basic conditions for a strong first order phase transition for SU(N) dark sectors with n_f flavours, calculate the gravitational wave spectrum and show that, depending on the dark confinement scale, it can be detected at eLISA or in pulsar timing array experiments. The gravitational wave signal provides a unique test of the gravitational interactions of a dark sector, and we discuss the complementarity with conventional searches for new dark sectors. The discussion includes Twin Higgs and SIMP models as well as symmetric and asymmetric composite dark matter scenarios.
description: 12 pages, 3 figures. v2: Added references, Fig. 3 improved
(502330) Emma Doswell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Methylating mushrooms
Creators: name: Bowers, A.A.
Publisher: name: Nature Publishing Group
Year: 2017

description: Peptide N-methylation is an important strategy used by medicinal chemists to improve cell permeability, oral bioavailability, and target affinity of peptide-based inhibitors. Correspondingly, N-methyl amides appear extensively in bioactive natural products. In the case of the immunosuppressant cyclosporine, for example, specific N-methylation of seven out of ten backbone amide nitrogens in the cyclic decapeptide is thought to allow a conformational ‘shapeshifting’ that hides polar N–H moieties and facilitates passive diffusion across cell membranes. Until now, N-methylation has primarily been the mark of peptide natural products from complex nonribosomal peptide synthetase (NRPS) assembly lines, and has not previously been found among their cousins, the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. In this issue, van der Velden et al. uncover the biosynthetic origins of the omphalotins, peptide natural products from the bioluminescent fungus O. olearius (Fig. 1a), and bring peptide backbone N-methylation into the realm of peptide post-translational modifications.
(502331) Evelyn Alice Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 5 of Medical decision-making in hospices from the viewpoint of physicians: results from two qualitative studies
Creators: name: Walker, Andreas
name: Breitsameter, Christof
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: Additional file 5. Medical decision-making in hospices COREQ Checklist.
(502334) Henry Comely
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Low-Mass Dielectron Production in pp, p-Pb and Pb-Pb Collisions with ALICE
Creators: name: Reichelt, Patrick
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The ALICE Collaboration measures the production of low-mass dielectrons in pp, p-Pb and Pb-Pb collisions at the LHC. The main detectors used in the analyses are the Inner Tracking System, Time Projection Chamber and Time-Of-Flight detector, all located around mid-rapidity. The production of virtual photons relative to the inclusive yield in pp collisions is determined by analyzing the dielectron excess with respect to the expected hadronic sources. The direct photon cross section is then calculated and found to be in agreement with NLO pQCD calculations. Results from the invariant mass analysis in p-Pb collisions show an overall agreement between data and hadronic cocktail. In Pb-Pb collisions, uncorrected background-subtracted yields have been extracted in two centrality classes. A feasibility study for LHC run 3 after the ALICE upgrade indicates the possibility for a future measurement of the early effective temperature.
description: 4 pages, 6 figures, Proceedings of Hot Quarks 2014 workshop, September 21-27, 2014, Las Negras, Spain
SELF –DISINFECTANT SURFACES FOR HEALTHIER ENVIRONMENTS –NEW EU PROJECT WORKING ON INNOVATIVEHOLISTIC SOLUTION OF SMART RESPONSE ANTIMICROBIAL NANOCOATINGS
Creators: name: Hristova, Ana
Publisher: name: Zenodo
Year: 2024
Subjects: nanoparticles
nanocoatings

description: First Press Release announcing the launch of RELIANCE project. 

A GREAT NUMBER OF PATHOGENIC MICROORGANISMS CAN SURVIVE FOR MONTHS ON SURFACES,CAUSING THE TRANSMISSION OF A WIDE RANGE OF INFECTIONS, WHICH ARE CONSIDERED TO BEONE OF THE MAJOR SINGLE CAUSES OF DEATH WORLDWIDE. ANTIBIOTIC RESISTANT MICROBIALINFECTIONS ALONE ARE RESPONSIBLE FOR AN ESTIMATED 110,000 LIVES LOST (OECD HEALTHREPORT 2016) AND 1.5 BILLION EUR IN HEALTHCARE COSTS AND PRODUCTIVITY LOSSES PER YEAR.Currently existing antimicrobial coatings raise concerns related to their antibiotic resistance,complex chemical synthesis, toxicity, non-biodegradability and extremely low sustainability in termsof product performance and environmental protection. The new Horizon Europe interdisciplinaryproject RELIANCE addresses the growing need for innovative antimicrobial coatings that are highlyeffective, safe, self-disinfecting and removing bacteria, fungi and viruses in a more efficientcost/performance ratio than the presently used petrochemical-based ones.
(501962) Elizabeth Evans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Thermoelectric transport properties of a T-shaped double quantum dot system in the Coulomb blockade regime
Creators: name: Monteros, A. L.
name: Uppal, G. S.
name: McMillan, S. R.
name: Crisan, M.
name: Tifrea, I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the thermoelectric properties of a T-shaped double quantum dot system described by a generalized Anderson Hamiltonian. The system's electrical conduction (G) and the fundamental thermoelectric parameters such as the Seebeck coefficient ($S$) and the thermal conductivity ($κ$), along with the system's thermoelectric figure of merit (ZT) are numerically estimated based on a Green's function formalism that includes contributions up to the Hartree-Fock level. Our results account for finite onsite Coulomb interaction terms in both component quantum dots and discuss various ways leading to an enhanced thermoelectric figure of merit for the system. We demonstrate that the presence of Fano resonances in the Coulomb blockade regime is responsible for a strong violation of the Wiedemann-Franz law and a considerable enhancement of the system's figure of merit ($ZT$).
description: 7 pages, 10 figures
(502328) Katherine Boyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Description of Emergency Medical Services, treatment of cardiac arrest patients and cardiac arrest registries in Europe
Creators: name: Tjelmeland, Ingvild B. M.
name: Masterson, Siobhan
name: Herlitz, Johan
name: Wnent, Jan
name: Bossaert, Leo
name: Rosell-Ortiz, Fernando
name: Alm-Kruse, Kristin
name: Bein, Berthold
name: Lilja, Gisela
name: Jan-Thorsten Gräsner
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. EMS survey.
State transfer based on classical nonseparability
Creators: name: Rafsanjani, Seyed Mohammad Hashemi
name: Mirhosseini, Mohammad
name: Magaña-Loaiza, Omar S.
name: Boyd, Robert W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a state transfer protocol that is mathematically equivalent to quantum teleportation, but uses classical nonseparability instead of quantum entanglement. In our implementation we take advantage of nonseparability among three parties: orbital angular momentum (OAM), polarization, and the radial degrees of freedom of a beam of light. We demonstrate the transfer of arbitrary OAM states, in the subspace spanned by any two OAM states, to the polarization of the same beam.
Additional file 1 of Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials
Creators: name: Kamel, Ahmed M.
name: Sabry, Nirmeen
name: Farid, Samar
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Search Strategy, Calculation Formulas, and Sensitivity Analysis.
Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Creators: name: Yumerefendi, H.
name: Hwang, S.
name: Kuhlman, B.
name: Grove, T.L.
name: Almo, S.C.
name: Bowers, A.A.
name: Himes, P.M.
name: Bonanno, J.B.
Publisher: name: American Chemical Society
Year: 2017

description: Sactipeptides are ribosomally synthesized peptides that contain a characteristic thioether bridge (sactionine bond) that is installed posttranslationally and is absolutely required for their antibiotic activity. Sactipeptide biosynthesis requires a unique family of radical SAM enzymes, which contain multiple [4Fe-4S] clusters, to form the requisite thioether bridge between a cysteine and the α-carbon of an opposing amino acid through radical-based chemistry. Here we present the structure of the sactionine bond-forming enzyme CteB, from Clostridium thermocellum ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate at 2.04 Å resolution. CteB has the (β/α)6-TIM barrel fold that is characteristic of radical SAM enzymes, as well as a C-terminal SPASM domain that contains two auxiliary [4Fe-4S] clusters. Importantly, one [4Fe-4S] cluster in the SPASM domain exhibits an open coordination site in absence of peptide substrate, which is coordinated by a peptidyl-cysteine residue in the bound state. The crystal structure of CteB also reveals an accessory N-terminal domain that has high structural similarity to a recently discovered motif present in several enzymes that act on ribosomally synthesized and post-translationally modified peptides (RiPPs), known as a RiPP precursor peptide recognition element (RRE). This crystal structure is the first of a sactionine bond forming enzyme and sheds light on structures and mechanisms of other members of this class such as AlbA or ThnB.
(502329) Hester Doswell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis
Creators: name: Hwang, S.
name: Himes, P.M.
name: Allen, S.E.
name: Bowers, A.A.
Publisher: name: American Chemical Society
Year: 2016

description: Sactipeptides are peptide-derived natural products that are processed by remarkable, radical-mediated cysteine sulfur to α-carbon coupling reactions. The resulting sactionine thioether linkages give rise to the unique defined structures and concomitant biological activities of sactipeptides. An E. coli heterologous expression system, based on the biosynthesis of one such sactipeptide, subtilosin A, is described and this expression system is exploited to probe the promiscuity of the subtilosin A sactionine bond-forming enzyme, AlbA. These efforts allowed the facile expression and isolation of a small library of mutant sactipeptides based on the subtilosin A precursor peptide, demonstrating broad substrate promiscuity where none was previously known. Importantly, we show that the positions of the sactionine linkages can be moved, giving rise to new, unnatural sactipeptide structures. E. coli heterologous expression also allowed incorporation of unnatural amino acids into sactipeptides by means of amber-suppression technology, potentially opening up new chemistry and new applications for unnatural sactipeptides.
Amplitudes for High Energy Factorization via BCFW recursion
Creators: name: Serino, Mirko
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, an extension of the BCFW on-shell recursion relation suitable to compute gauge invariant scattering amplitudes with off-shell particles has been presented for Yang-Mills theories with fermions. In particular, 4- and 5-point amplitudes have been completely worked out. The results are needed for the study of multi-parton scattering at hadron colliders in the framework of High Energy Factorization (HEF).
description: 11 pages, 2 figures, talk presented at the XXI Cracow Epiphany Conference on Future High Energy Colliders, 8-10 January 2015
Dynamic Docking of Conformationally Constrained Macrocycles: Methods and Applications
Creators: name: Bowers, A.A.
name: Allen, S.E.
name: Dokholyan, N.V.
Publisher: name: American Chemical Society
Year: 2016

description: Many natural products consist of large and flexible macrocycles that engage their targets via multiple contact points. This combination of contained flexibility and large contact area often allows natural products to bind at target surfaces rather than deep pockets, making them attractive scaffolds for inhibiting protein-protein interactions and other challenging therapeutic targets. The increasing ability to manipulate such compounds either biosynthetically or via semisynthetic modification means that these compounds can now be considered as starting points for medchem campaigns rather than solely as ends. Modern medchem benefits substantially from rational improvements made on the basis of molecular docking. As such, docking methods have been enhanced in recent years to deal with the complicated binding modalities and flexible scaffolds of macrocyclic natural products and natural product-like structures. Here, we comprehensively review methods for treating and docking these large macrocyclic scaffolds and discuss some of the resulting advances in medicinal chemistry.
Additional file 2 of Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials
Creators: name: Kamel, Ahmed M.
name: Sabry, Nirmeen
name: Farid, Samar
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Risk of Bias Assessment in the Effect ofMetformin on Left Ventricular Mass Index (LVMI).
Typology of Energy Citizenship(s)
Creators: name: Dunphy, Niall
name: Revez, Alexandra
name: Lennon, Breffní
name: Brenner-Fließer, Michael
Publisher: name: ENCLUDE Project
Year: 2023

description: This deliverable comprises a typology of citizenship in the energy domain. It presents a scoping literature review on energy citizenship and related ideas. It includes a report on a comprehensive engagement of citizens, practitioners and experts through a mixed methods approach involving surveying, in-depth interviewing and asynchronous email interviews. A typology of energy citizenship is presented comprising four categories of 'access to energy', 'energy consumption', 'energy production', and 'politics and governance'. Fifteen expressions of energy citizenship were described, three under the first category, and four in each of the others. This report comprising the typology, the appreciation of an inclusive multifaceted energy citizenship that will underpin it, and the understanding of the different manifestations of citizenship around energy described in it will contribute to both understanding and mobilising the decarbonisation potential of the energy citizens. This report along with its companion report (D2.1) also contribute to the ongoing discourse (including with peer projects) on the role of citizenship in the energy transition and the meaning and value of energy citizenship.
Identification of Pyridine Synthase Recognition Sequences Allows a Modular Solid-Phase Route to Thiopeptide Variants
Creators: name: Wever, W.J.
name: Bogart, J.W.
name: Bowers, A.A.
Publisher: name: American Chemical Society
Year: 2016

description: Thiopeptides are structurally complex, bioactive natural products derived from ribosomally synthesized and post-translationally modified peptides. A remarkable set of enzymes were recently revealed to catalyze the formation of the core trithiazolylpyridine of thiopeptides via a formal [4 + 2] cycloaddition. These pyridine synthases typically act late in thiopeptide biosynthesis to affect macrocyclization and cleavage of the N-terminal leader peptide, making them potentially useful biocatalysts for preparation of new thiopeptide variants. Herein we investigate the leader peptide requirements for TclM from thiocillin biosynthesis in Bacillus cereus ATCC 14579. Through a series of truncations, we define a minimum recognition sequence (RS) that is necessary and sufficient for TclM activity. This RS can be readily synthesized and ligated to linear thiopeptide cores prepared via solid-phase peptide synthesis (SPPS), giving an efficient and modular route to thiopeptide variants. We exploit this strategy to define C-terminal core peptide requirements and explore the differences in promiscuity of two pyridine synthases, TclM and TbtD, ultimately examining their ability to access new structural variants.
Enzymatic basis of "hybridity" in thiomarinol biosynthesis
Creators: name: Dunn, Z.D.
name: Economou, N.J.
name: Bowers, A.A.
name: Li, B.
name: Wever, W.J.
Publisher: name: Wiley-VCH Verlag
Year: 2015

description: Thiomarinol is a naturally occurring double-headed antibiotic that is highly potent against methicillin-resistant Staphylococcus aureus. Its structure comprises two antimicrobial subcomponents, pseudomonic acid analogue and holothin, linked by an amide bond. TmlU was thought to be the sole enzyme responsible for this amide-bond formation. In contrast to this idea, we show that TmlU acts as a CoA ligase that activates pseudomonic acid as a thioester that is processed by the acetyltransferase HolE to catalyze the amidation. TmlU prefers complex acyl acids as substrates, whereas HolE is relatively promiscuous, accepting a range of acyl-CoA and amine substrates. Our results provide detailed biochemical information on thiomarinol biosynthesis, and evolutionary insight regarding how the pseudomonic acid and holothin pathways converge to generate this potent hybrid antibiotic. This work also demonstrates the potential of TmlU/HolE enzymes as engineering tools to generate new "hybrid" molecules. The biosynthetic mechanism responsible for generating the antibiotic thiomarinol was elucidated. In contrast to previous hypotheses, TmlU acts as a CoA-ligase and works in tandem with a second enzyme, acyltransferase HolE, to link two antimicrobial warheads pseudomonic acid and holothin, creating a hybrid antibiotic (see scheme).
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs
Creators: name: Wiest, O.
name: Estiu, G.
name: Smith, W.B.
name: Bradner, J.E.
name: Williams, R.M.
name: Paranal, R.
name: Guerra-Bubb, J.M.
name: Bowers, A.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described.
(501489) Charles Jaques Posno
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 3 of Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials
Creators: name: Kamel, Ahmed M.
name: Sabry, Nirmeen
name: Farid, Samar
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Risk of Bias Assessment in the Effect ofMetformin on Left Ventricular Ejection Fraction (LVEF).
Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature
Creators: name: Clardy, J.
name: Ross, R.P.
name: Dittmann, E.
name: Nes, I.F.
name: Van Der Donk, W.A.
name: Dorrestein, P.C.
name: Wenzel, S.C.
name: Walsh, C.T.
name: Severinov, K.
name: Mitchell, D.A.
name: Sivonen, K.
name: Link, A.J.
name: Sahl, H.-G.
name: Hemscheidt, T.K.
name: Tang, G.-L.
name: Camarero, J.A.
name: Süssmuth, R.D.
name: Moore, B.S.
name: Vederas, J.C.
name: Kelly, W.L.
name: Garavelli, J.S.
name: Craik, D.J.
name: Jaspars, M.
name: Norris, G.E.
name: Willey, J.M.
name: Schmidt, E.W.
name: Arnison, P.G.
name: Bulaj, G.
name: Patchett, M.L.
name: Challis, G.L.
name: Liu, W.
name: Hertweck, C.
name: Bibb, M.J.
name: Dawson, M.
name: Onaka, H.
name: Göransson, U.
name: Reaney, M.J.T.
name: Donadio, S.
name: Bugni, T.S.
name: Bierbaum, G.
name: Olivera, B.M.
name: Shen, B.
name: Fischbach, M.A.
name: Horswill, A.R.
name: Gruber, C.W.
name: Marahiel, M.A.
name: Bowers, A.A.
name: Rebuffat, S.
name: Smith, L.
name: Selsted, M.E.
name: Moll, G.N.
name: Hill, C.
name: Stein, T.
name: Klinman, J.P.
name: Cotter, P.D.
name: Haft, D.H.
name: Piel, J.
name: Müller, R.
name: Truman, A.W.
name: Nair, S.K.
name: Walton, J.D.
name: Entian, K.-D.
name: Kuipers, O.P.
name: Campopiano, D.J.
name: Tagg, J.R.
Publisher: name: Royal Society of Chemistry
Year: 2013

description: Covering: 1988 to 2012 This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
(501505) John Hunt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501958) James Barnes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Longitudinal and transverse cooling of relativistic electron beams in intense laser pulses
Creators: name: Yoffe, Samuel R.
name: Kravets, Yevgen
name: Noble, Adam
name: Jaroszynski, Dino A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: With the emergence in the next few years of a new breed of high power laser facilities, it is becoming increasingly important to understand how interacting with intense laser pulses affects the bulk properties of a relativistic electron beam. A detailed analysis of the radiative cooling of electrons indicates that, classically, equal contributions to the phase space contraction occur in the transverse and longitudinal directions. In the weakly quantum regime, in addition to an overall reduction in beam cooling, this symmetry is broken, leading to significantly less cooling in the longitudinal than the transverse directions. By introducing an efficient new technique for studying the evolution of a particle distribution, we demonstrate the quantum reduction in beam cooling, and find that it depends on the distribution of energy in the laser pulse, rather than just the total energy as in the classical case.
description: 19 pages, 5 figures. arXiv admin note: text overlap with arXiv:1410.1759
title: Spinal tuberculosis leading to osteomyelitis and multiple abscesses
Creators: name: Lautt, Wyatt
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Musculoskeletal system
subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue
subject: Neuroradiology spine
subject: CT
subject: MR
subject: Clinical Case

description: Clinical History: 30-year-old male who recently immigrated from Africa presents with progressively worsening upper back pain for the past 2 years that now radiates to his right flank. He also has been experiencing night sweats, anorexia, and weight loss recently. He denies cough or shortness of breath.

description: 30 years, male
INTERNATIONAL ACADEMIC MOBILITY IN TOURISM VOCATIONAL EDUCATION AS A FACTOR OF THE INTERNATIONAL LABOR MARKET’S DEVELOPMENT
Creators: name: Smith Natalia, L.
name: Ilkevich Sergey, V.
Publisher: name: Сервис в России и за рубежом
Year: 2022
Subjects: TOURISM
HOSPITALITY
QUALIFICATIONS
NATIONAL QUALIFICATIONS FRAMEWORK
PROFESSIONAL STANDARDS
EDUCATIONAL STANDARDS
VOCATIONAL EDUCATION
TOURISM EDUCATION
LABOR MARKET
ACADEMIC MOBILITY
INTERNATIONALIZATION AT HOME

description: Russian tourism vocational education has faced a number of restructuring measures in recent years and is now making progress in becoming a sustainable system integrated into the higher education system and the international labor market with a high degree of readiness for further development and innovation. However, the global pandemic has shown that some optimization of the structure and priorities of Russian vocational education in the field of tourism is still desirable. This paper presents an analysis of major problems and possible ways to overcome them from the standpoint of educational design, including such issues as international academic mobility, credit transfer, blended learning. The paper also expands on features of internationalization abroad and at home in the context of challenges and opportunities in the post-COVID era. The central research issue is interrelations between academic mobility, tourism vocational education and labor market. The authors argue that in many configurations of circumstances the best way for the development of international academic mobility is blended mobility, which could become the most important link between secondary vocational and higher tourism education of both Russian and foreign educational organizations - and, thus, lead to a sustainable supply of human resources in the international labor market. The paper also approaches the shortage of highly qualified personnel in the rapidly growing tourism sector. This problem is becoming chronic. In this regard, the formation of a structured framework of qualifications in the form of the national qualifications system is in high demand not only as a general institution for the strategic development of Russian educational organizations, but also as a means of training personnel, technologies, competencies and innovative potential of the tourism and hospitality industry. The formation of the national qualifications framework in the Russian Federation with respect to the tourism sector can gradually increase relevance of vocational tourism education to the labor market’s demands both in Russia and abroad.
The California Planet Survey IV: A Planet Orbiting the Giant Star HD 145934 and Updates to Seven Systems with Long-Period Planets
Creators: name: Feng, Y. Katherina
name: Wright, Jason T.
name: Nelson, Benjamin
name: Wang, Sharon X.
name: Ford, Eric B.
name: Marcy, Geoffrey W.
name: Isaacson, Howard
name: Howard, Andrew W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present an update to seven stars with long-period planets or planetary candidates using new and archival radial velocities from Keck-HIRES and literature velocities from other telescopes. Our updated analysis better constrains orbital parameters for these planets, four of which are known multi-planet systems. HD 24040 b and HD 183263 c are super-Jupiters with circular orbits and periods longer than 8 yr. We present a previously unseen linear trend in the residuals of HD 66428 indicative on an additional planetary companion. We confirm that GJ 849 is a multi-planet system and find a good orbital solution for the c component: it is a $1 M_{\rm Jup}$ planet in a 15 yr orbit (the longest known for a planet orbiting an M dwarf). We update the HD 74156 double-planet system. We also announce the detection of HD 145934 b, a $2 M_{\rm Jup}$ planet in a 7.5 yr orbit around a giant star. Two of our stars, HD 187123 and HD 217107, at present host the only known examples of systems comprising a hot Jupiter and a planet with a well constrained period $> 5$ yr, and with no evidence of giant planets in between. Our enlargement and improvement of long-period planet parameters will aid future analysis of origins, diversity, and evolution of planetary systems.
description: 16 pages, 13 figures. Accepted for publication in ApJ
(501490) John Francis Sparke
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501959) Thomas Edwin Hough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501474) Elizabeth Elliott
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Stochastic Chemical Kinetics. Theory and (Mostly) Systems Biological Applications, P. Erdi, G. Lente. Springer (2014)
Creators: name: Bibbona, Enrico
Publisher: name: arXiv
Year: 2014
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: Book review of Stochastic Chemical Kinetics. Theory and (Mostly) Systems Biological Applications, P. Erdi, G. Lente. Springer (2014)
A Backup Plan for Self-Protection: S-Methylation of Holomycin Biosynthetic Intermediates in Streptomyces clavuligerus
Creators: name: Forseth, R.R.
name: Schroeder, F.C.
name: Bowers, A.A.
name: Walsh, C.T.
name: Li, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Biosynthesis of the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus involves the closure of a pair of enethiols to a cyclic disulfide. We have shown that the dithiol oxidase HlmI is responsible for the disulfide formation and this enzyme also plays a role in self-protection. In the present study, we examine how S. clavuligerus deals with the proposed toxic dithiol intermediates when hlmI is deleted. We used differential NMR spectroscopy and mass spectrometry to profile the metabolomes of hlmI deletion mutants along with the wild-type strain and a holomycin-overproducing strain. A number of metabolites unique to ΔhlmI strains were identified. In these metabolites the enethiols have been incapacitated by a combination of mono- and di-S-methylation. We also observed an intriguing dimeric thioether adduct in low quantities in the wild-type strain and at much higher levels in the ΔhlmI strains. The structures of these novel metabolites highlight the reactivity of the dihydrodithiolopyrrolone scaffold. Furthermore, bioassays suggest that modification of the enethiol warhead by S-alkylation provides a host strategy for detoxification, one that is shared amongst multiple species producing such bioactive disulfide natural products.
(501475) Edmund Elliott
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus
Creators: name: Acker, M.G.
name: Bowers, A.A.
name: Young, T.S.
name: Walsh, C.T.
Publisher: name: American Chemical Society
Year: 2012

description: The thiocillins from Bacillus cereus ATCC 14579 are natural products from the broader class of thiazolyl peptides. Their biosynthesis proceeds via extensive post-translational modification of a ribosomally encoded precursor peptide. This post-translational tailoring involves a key step formal cycloaddition between two distal serine residues. In the wild-type structure, this cycloaddition forms a major macrocycle circumscribed by 26-atoms (shortest path). Results presented herein demonstrate the promiscuity of this last step by means of a set of "competition" experiments. Cyclization proceeds in many cases to provide altered ring sizes, giving access to several variant rings sizes that have not previously been observed in nature.
(501488) Charles Wynn Finch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
In vivo evaluation of wearable head impact sensors
Creators: name: Wu, Lyndia C.
name: Nangia, Vaibhav
name: Bui, Kevin
name: Hammoor, Bradley
name: Kurt, Mehmet
name: Hernandez, Fidel
name: Kuo, Calvin
name: Camarillo, David B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Medical Physics (physics.med-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Inertial sensors are commonly used to measure human head motion. Some sensors have been validated with dummy or cadaver experiments, but methods to evaluate sensors in vivo are lacking. Here we present an in vivo method using high speed video to evaluate teeth-mounted (mouthguard), soft tissue-mounted (skin patch), and headgear-mounted (skull cap) sensors during 6-13g sagittal soccer head impacts. Sensor coupling to the skull is quantified by displacement from an ear-canal reference. Mouthguard displacements were within video measurement error (<1mm), while the skin patch and skull cap displaced up to 4mm and 13mm from the ear-canal reference, respectively. We used the mouthguard, which had the least displacement from skull, as the reference to assess 6-degree-of-freedom skin patch and skull cap measurements. Linear and rotational acceleration magnitudes were over-predicted by both the skin patch (with 120% NRMS error for a_mag, 290% for alpha_mag) and the skull cap (320% NRMS error for a_mag, 500% for alpha_mag). Such over-predictions were largely due to out-of-plane motion. To model sensor error, we found that in-plane acceleration peaks from the skin patch in the anterior-posterior direction could be modeled by an underdamped viscoelastic system. In summary, the mouthguard showed tighter skull coupling in vivo than the other sensors. Furthermore, the in vivo methods presented are valuable for investigating skull acceleration sensor technologies.