cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A DESCONSTITUIÇÃO DA COISA JULGADA EM  AÇÕES DE INVESTIGAÇÃO DE PATERNIDADE  NO BRASIL
Creators: name: Marcellus Polastri Lima
name: Renata Vitória Oliveira S. Trancoso
Publisher: name: Zenodo
Year: 2013

description: Resumo: Doutrina e jurisprudência se inclinam a encontrar soluções adequadas para ultrapassar a imutabilidade de determinadas decisões. Em alguns momentos, são colocados em colisão valores que, em ponderação com a segurança jurídica, possam sobrepô-la. Desta feita, apesar do ordenamento jurídico apresentar soluções para a desconstituição da coisa julgada, se sabe que há a pretensão de abandonar os mecanismos previstos, visando desconstituir a coisa julgada, quando esta for declarada inconstitucional, por exemplo quando afrontar a dignidade humana. Notadamente, recente decisão da Suprema Corte brasileira permitiu fosse desconstituído determinado julgado, baseando-se em princípios constitucionais, sem necessidade de ação rescisória. Inúmeros são os questionamentos e, brevemente, no presente artigo,o que se pretende é contrapor a decisão da Suprema Corte, com as soluções apresentadas por doutrina e jurisprudências existentes quanto ao tema. Palavras-chave: Recurso Extraordinário; Coisa julgada; Desconstituição; Investigação de Paternidade.
Fiche d'inventaire - Objet n° 7337 - Socle ?
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: Relation: JFCA, tome 23, p. 195
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 7309 - Buddha en samādhi
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: Relation: JFCA, tome 15, p. 5, 1
description: IIIF manifest
description: created: 1950/1970
title: PlanRomePlaque01 44
Creators: name: Galinand, Cyrille
name: Université Paris1 Panthéon-Sorbonne
Publisher: name: Archeovision
Year: 2024
Subjects: subject: Rome antique
subject: plan relief
subject: Paul Bigot

description: Plan de la Rome antique
description: 1 fichier 3D (ply), 213 fichiers image (jpg)
Fiche d'inventaire - Objet n° 7072 - Gong (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: Relation: Double de 7072
description: IIIF manifest
description: created: 1950/1970
Cross-Domain Knowledge Transfer using LLMs and Domain-Specific Knowledge Graphs
Creators: name: Kumar
Publisher: name: Zenodo
Year: 2025

description: Given today’s data-driven landscape, the art of transferring knowledge across diverse domains is really crucial for developing versatile and intelligent systems. This research paper presents an investigation of cross-domain knowledge transfer in Large Language Models combined with domain-specific knowledge graphs. Through this work, we envision harvesting the expansive language understanding capabilities of LLMs with structured contextual information provided by the specialized knowledge graphs to foster better and more accurate knowledge dispersion between different fields. Our approach with LLMs, using Wikidata, DBpedia, and domain-specific repositories of factual data, demonstrates much better performance in tasks like entity recognition, relationship extraction, and semantic rea- soning on a wide variety of domains. This is because the synergy of LLMs and knowledge graphs brings better model adaptability and precision, bridges gaps between different knowledge areas, and allows applications in healthcare, finance, and environmental science. Our results point to the potential of this integrative methodology to move artificial intelligence systems forward in be- coming more robust, context-sensitive, and capable of exploiting specialized knowledge in complex, real-world problem-solving.
“Out of touch” - recovering sensibility after burn injury : a review of the literature
Creators: name: Tsolakidis, Savas
name: Alharbi, Ziyad
name: Rennekampff, Hans Oliver
name: Schmidhammer, Markus Robert
name: Schmidhammer, Robert
name: Rosenauer, Rudolf
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: burn injury
subject: full-thickness burn injury
subject: sensory regeneration
subject: cutaneous sensibility
subject: nerve injury
subject: nerve regeneration
subject: skin grafting
subject: DDC 610 / Medicine & health
subject: Burns
subject: Peripheral nerve injuries
subject: Nerve regeneration
subject: Skin transplantation
subject: Verbrennung
subject: Nervenverletzung
subject: Nervenregeneration
subject: Hauttransplantation
subject: Sinneszelle
subject: Regeneration

description: Background: Full-thickness burn injuries (FTBI) not only lead to a significant burden in multiple ways, including social life and self-esteem, but have also a tremendous impact on environmental interaction by reducing sensibility in manifold ways. On these grounds, possible ways and solutions to recover sensibility in burn wounds are essentials and should not be overlooked. Methods: A review of experimental, clinical studies and the related literature was performed with the aim to highlight post-burn nerve regeneration and discover ways for sensory re-integration to complement the therapeutic concept. Results: In human burn injuries, it has been hypothesized that grafted cells, partly multipotent stem cells, could be additionally responsible for nerve regeneration in burn wound areas. In addition, burn eschar excision, performed within a short post-burn time frame, can reduce or even avoid long-term nerve damage by reducing post-burn toxic mediator release. Various animal studies could demonstrate sensory reinnervation of different qualities in burn wounds. Post-burn scar tissue prevents, or at least decelerates, nerve reinnervation, but could be reduced by targeted mediators. Conclusion: Sensory loss is present in skin grafted areas following full-thickness burn-wound excision, thereby leading to a reduction in quality of life. In addition, various mediators might reduce or avoid nerve damage and should be considered at an early stage as part of a holistic burn-patient therapeutic approach. In addition, supportive multifaceted physical therapy strategies are essential.
Community Vigilante Groups in Nigeria: A Review of its Activities and Regulatory Policies
Creators: name: Oaikhena, Marvellous
Publisher: name: Zenodo
Year: 2024

description: Abstract

Vigilante groups are found in communities. Their introduction has helped filled the gaps existed in the police and other law enforcement agencies to curb crime, as they complement the efforts of security and law enforcement agencies, who have been overwhelmed by crime and criminality in most Nigeria communities.  Vigilante groups came into existence in Nigeria in 1970. It was meant to combat the rising cases of criminal activities in communities.  Over the years vigilante groups have become parts of the landscape of Nigeria’s security agencies.  The groups have also been criticized and accused of human right abuses and violation.  They have been said to have engaged in extrajudicial killings and unauthorized arrest, harassment and unlawful detention of innocent citizens in their various local communities. The objectives of this study were set to find out if there are regulatory policies guiding the activities of vigilante groups; if they adhere to laid down policies establishing them; and if they have made meaningful impact on the overall security situation in the country. This study adopted quantitative and the secondary method of data generation, which is based on reported cases.  The study adopted public interest theory, which is one of the key elements of regulatory theory. The study concluded that vigilante groups should be given clear responsibilities in other to collaborate meaningfully with the police and other law enforcement agencies.  As it also advocated that proper training and compensation packages should be accorded to them, in line with best practices.

 

Key word: Vigilante groups, security agencies, regulatory policy, communities
sj-docx-1-scm-10.1177_00369330221132156 - Supplemental material for Half a century of the inverse care law: A comparison of general practitioner job satisfaction and patient satisfaction in deprived and affluent areas of Scotland
Creators: name: Mercer, Stewart W
name: Lunan, Carey J
name: MacRae, Clare
name: Henderson, David AG
name: Fitzpatrick, Bridie
name: Gillies, John
name: Guthrie, Bruce
name: Reilly, Johanna
Publisher: name: SAGE Journals
Year: 2022
Subjects: Medicine

description: Supplemental material, sj-docx-1-scm-10.1177_00369330221132156 for Half a century of the inverse care law: A comparison of general practitioner job satisfaction and patient satisfaction in deprived and affluent areas of Scotland by Stewart W Mercer, Carey J Lunan, Clare MacRae, David AG Henderson, Bridie Fitzpatrick, John Gillies, Bruce Guthrie and Johanna Reilly in Scottish Medical Journal
Fiche d'inventaire - Objet n° 7164 - Feuilles d'or
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Or

description: Source: FCA/3/2
description: Relation: JFCA, tome 16, p. 198, 17
description: IIIF manifest
description: created: 1950/1970
sj-docx-4-pie-10.1177_09544089221131666 - Supplemental material for Animal waste powder utilization for Al6061/SiC composite using friction stir processing with scroll shoulder hexagonal tool
Creators: name: Gupta, Prateek
name: Singh, Hari
name: Kumar, Sudhir
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-4-pie-10.1177_09544089221131666 for Animal waste powder utilization for Al6061/SiC composite using friction stir processing with scroll shoulder hexagonal tool by Prateek Gupta, Hari Singh and Sudhir Kumar in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Additional file 1 of Human-centered participatory co-design with children and adults for a prototype lifestyle intervention and implementation strategy in a rural middle school
Creators: name: Watkins, Janette M.
name: Greeven, Sarah J.
name: Heeter, Kathleen N.
name: Brunnemer, Julia E.
name: Otile, Jacob
name: Solá, Paola A. Fernández
name: Dutta, Sandeep
name: Hobson, James M.
name: Evanovich, Justin M.
name: Coble, Cassandra J.
name: Werner, Nicole E.
name: Martinez Kercher, Vanessa M.
name: Kercher, Kyle A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Fiche d'inventaire - Objet n° 7184_1_40 - 40 Preah Patima
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Or
Argent

description: Source: FCA/3/2
description: Relation: JFCA, tome 24, p. 345
description: IIIF manifest
description: created: 1950/1970
Design of consumer thermal substations for the integration of distributed solar technologies in District Heating systems
Creators: name: Garay, Roberto
name: Sánchez, Víctor
Publisher: name: Zenodo
Year: 2018
Subjects: Ultra-Low temperature
district heating
ULTDH
renewable energy
heating system
new urban developments
solar thermal
DT networks

description: Victor Sanchez and Roberto Garay, of Tecnalia, presented a new consumer substation on the 5th International Solar District Heating Conference. This concept of substation for the connection of Solar Thermal into District Heating networks, will be developed within RELaTED project. In most cases, building service designers choose between Solar thermal (ST) and District Heating (DH) technologies for their integration in buildings. By doing so, only a fraction of the buildings within a particular district is used for ST, while at the same time energy intensity in DH networks can be reduced. In some cases, building-integrated solar thermal systems are connected to DH networks by means of dedicated pipes. In all these cases, sub-optimal situations are reached with lower fraction of renewable heat, reduced network strength and/or additional heat losses. In this paper, a consummer substation concept is proposed with reversible heat flow and net metering, which avoids local thermal storage in the solar loop. Adaptations required for multi-dwelling buildings are presented.
sj-docx-1-hsx-10.1177_10887679221128006 – Supplemental material for The Influence of Racial Minorities and Ethnic Heterogeneity in the Estimation of Homicide Rates in the Northeast Region of Brazil: Implications for Social Disorganization Theory in the Global South
Creators: name: Silva, Carlos Fabricio Assunção da
name: de Melo, Silas Nogueira
name: Vaughan, Adam David
name: Santos, Alex Mota dos
name: de Almeida Junior, Pedro Monteiro
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, sj-docx-1-hsx-10.1177_10887679221128006 for The Influence of Racial Minorities and Ethnic Heterogeneity in the Estimation of Homicide Rates in the Northeast Region of Brazil: Implications for Social Disorganization Theory in the Global South by Carlos Fabricio Assunção da Silva, Silas Nogueira de Melo, Adam David Vaughan, Alex Mota dos Santos and Pedro Monteiro de Almeida Junior in Homicide Studies
Fiche d'inventaire - Objet n° 7239
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
sj-docx-1-jbf-10.1177_22808000221131881 – Supplemental material for Protein-corona formation on aluminum doped zinc oxide and gallium nitride nanoparticles
Creators: name: Ciobanu, Vladimir
name: Roncari, Francesco
name: Ceccone, Giacomo
name: Braniste, Tudor
name: Ponti, Jessica
name: Bogni, Alessia
name: Guerrini, Giuditta
name: Cassano, Domenico
name: Colpo, Pascal
name: Tiginyanu, Ion
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: Supplemental material, sj-docx-1-jbf-10.1177_22808000221131881 for Protein-corona formation on aluminum doped zinc oxide and gallium nitride nanoparticles by Vladimir Ciobanu, Francesco Roncari, Giacomo Ceccone, Tudor Braniste, Jessica Ponti, Alessia Bogni, Giuditta Guerrini, Domenico Cassano, Pascal Colpo and Ion Tiginyanu in Journal of Applied Biomaterials & Functional Materials
Interference of chirp sequence radars by OFDM radars at 77 GHz
Creators: name: Knill, Christina
name: Bechter, Jonathan
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: DDC 620 / Engineering & allied operations
subject: Orthogonal frequency division multiplexing
subject: Signal processing
subject: Radar
subject: OFDM
subject: Signalverarbeitung
subject: Interferenz
subject: Chirpradar

description: Radar sensors are common devices in daily traffic, especially for driver assistance and automotive safety systems. A high sensor density increases the probability of interferences, especially when the sensors occupy a large radar bandwidth. Many current sensors, e.g. chirp sequence radars, rely on frequency modulation schemes. A promising future radar concept applies orthogonal frequency division multiplexing (OFDM). This paper investigates the interference effect of an OFDM radar on a chirp sequence radar. Potential interference levels are derived and the influence of modulation parameters is evaluated with simulations.
Fiche d'inventaire - Objet n° KTM 47_48_49_50 - Bracelets
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Argent

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Towards More Factual Large Language Models: Parametric and Non-parametric Approaches
Creators: name: Jiang, Zhengbao
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: Natural Language Processing

description: Large language models (LLMs) are increasingly important in assisting people  to access information, ranging from simple factoid questions such as “where is  the world’s largest ice sheet located” to complex questions that require accessing  real-time information and reasoning such as “plan a vacation in Miami”. There  are two paradigms to handle questions that require factual knowledge: parametric approaches that store knowledge within the parameters of LLMs and elicit this knowledge through prompting, and non-parametric approaches that offload knowledge retrieval to an external non-parametric datastore. In this dissertation, we aim  to study, compare, and enhance the capacity of both paradigms.  
Since LLMs have accumulated a large amount of knowledge within their parameters through pre-training on diverse corpora, they can directly generate answers  when prompted with questions. In the first part of the dissertation, we focus on  parametric approaches that utilize the factual knowledge contained in the parameters of LLMs. We first study methods to extract more knowledge by ensembling  multiple predictions derived from diverse prompts. Then, we calibrate LLMs to  make them trustworthy when answering questions that fall beyond their scope  of knowledge. We find that after LLMs memorize documents perfectly to the extent of reproducing them verbatim, they still often fail to answer questions about  them. To enhance the capacity of LLMs to absorb knowledge from documents, we  propose pre-instruction-tuning that teaches them the task of question-answering  before pre-training them on documents. 
Parametric approaches offer a simple interface, but they suffer from hallucinations and lack access to real-time external information. In the second part of  the dissertation, we focus on non-parametric approaches that augment LLMs with  a non-parametric datastore, typically constructed from a document corpus and a  retriever. The standard retrieval-augmented generation (RAG) pipeline consists of  an embedding-based retriever and an LLM-based-generator, which typically require  separate training procedures and are often limited by the retriever’s performance.  We introduce an end-to-end solution that fuses retrieval and generation within  a single transformer and directly uses the attention mechanism for retrieval purposes. To address complex questions demanding detailed responses, we introduce  Active RAG, which dynamically and proactively retrieves information throughout  the generation process. Finally, we conclude by comparing and reconciling both  paradigms and providing insight into future directions.
Additional file 2 of Human-centered participatory co-design with children and adults for a prototype lifestyle intervention and implementation strategy in a rural middle school
Creators: name: Watkins, Janette M.
name: Greeven, Sarah J.
name: Heeter, Kathleen N.
name: Brunnemer, Julia E.
name: Otile, Jacob
name: Solá, Paola A. Fernández
name: Dutta, Sandeep
name: Hobson, James M.
name: Evanovich, Justin M.
name: Coble, Cassandra J.
name: Werner, Nicole E.
name: Martinez Kercher, Vanessa M.
name: Kercher, Kyle A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
sj-doc-4-tct-10.1177_15330338221132669 - Supplemental material for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer
Creators: name: Yue, Yuhan
name: Liang, Junqing
name: Wu, Yuruo
name: Tong, Weibing
name: Li, Dan
name: Cao, Xuchen
name: Wang, Xin
Publisher: name: SAGE Journals
Year: 2022
Subjects: Oncology and Carcinogenesis not elsewhere classified
Radiology and Organ Imaging
Biochemistry

description: Supplemental material, sj-doc-4-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment
تحلیل گلدمنی قهرمان مسئله دار در آثار جمال میرصادقی (درازنای شب و کلاغ ها و آدم ها)
Publisher: name: دانشگاه کردستان
Year: 2022

description: رمان، درمقام مهمترین شکل ادبی دوران مدرن، به روایت سرگذشت انسان مسئله دار و توصیف جریانهای اجتماعی\nمیپردازد. تحلیل شخصیت و وضعیت قهرمان مسئله دار در رمان را نخست جرج لوکاچ و سپس لوسین گلدمن مطرح کرد\nاز منظر این رویکرد، کارکرد اصلی رمان، جستجو و ورایت تباهی انسان در جامعۀ مدرن است، چراکه این تباهی پیوندهی\nناگسستنی با ساختارهای اجتماعی مدرنیته دارد. رمان به مثابه گونۀ ادبیِ همزاد مدرنیته پابه پای تحّولات جامعۀ مدرن\nتحول مییابد و قهرمان آن همان فرد معمولی است که در متن زندگی روزمرۀ مدرن با مسایل و معضلات این عصر دست\nو پنجه نرم میکند. جمال میرصادقی نویسندهای است واقعگرا که آثارش بازتابی از حوادث و وقایع تاریخی است و میتوان\nشاخصه های شخصیت پروبلماتیک را به طور خاص در دو رمان او، درازنای شب و کلاغها و آدمها، مشاهده کرد. این پژوهش\nبه شیوهای تحلیلی-توصیفی و با به رهگیری از نظریۀ گلدمن به بررسی مهمترین ویژگیهای شخصیت پروبلماتیک در این\nدو رمان میپردازد. نتایج تحقیق نشان میدهد که قهرمان، در هر دو رمان، شخصیت پروبلماتیکی است که بنا به ویژگی-\nهایی چون فردیت، پیروی از ارزشهای راستین، مخالفت با اجتماع و درحاشیه بودن شاهد تباهی ارزشهای راستین در\nجامعه است و در نهایت تداوم همین مسیر مرگ او را درمقام انسانی مسئله دار رقم میزند
Corbel Elsi Guidance For New Scientific, Technological And Cross-Border Developments Using A "Help-Desk Format"
Creators: name: Mayrhofer, Michaela Th.
name: Schlünder, Irene
Publisher: name: Zenodo
Year: 2018
Subjects: Ethical, Legal and Societal Issues
Cross-border guidance
Biomedical Research Infrastructures

description: In combination with a customized support provided by the BBMRI-ERIC Common Service ELSI Helpdesk, the ELSI Knowledge Base will be available to the user on a self-serve basis. The knowledge base provides users with a first orientation on the subject matter, as well as allowing them to explore more detailed information if desired in a self-service manner. It is crucial that the information and knowledge provided are shared in a manner that is user friendly. Long lists of links, legalistic language, and multiple links have to be avoided wherever possible. The long-term sustainability and accuracy of a knowledge base need to be ensured by placing its expert curation and technical maintenance under the responsibility of an organization rather than a research consortium. In its core, it builds on a scenario-based approach using a non-legalistic language. In addition, the knowledge base connects to frequently asked questions, promotes contract and informed consent templates, how-to-guides, best-practice models, and scripts. The ELSI Knowledge Base is a key element of the BBMRI-ERIC Common Service ELSI, which currently serves biobanks but will be enlarged to serve the biological and medical sciences community. In contrast to the ELSI Helpdesk, which provides customized support, the ELSI Knowledge Base is available to the user on a self-serve basis. The conceptualization of the ELSI Knowledge Base builds on assessments of several ethical, legal, and societal guidance tools that favor a single sustainable knowledge base for closing the knowledge gap by providing practical hands-on guidance for researchers. Ultimately, the ELSI Knowledge Base aims at promoting practical know-how and skills for

conducting responsible research. The ELSI Knowledge Base is a key element of the BBMRI-ERIC Common Service ELSI, which currently serves biobanks but shall be enlarged to serve the BMS community. In contrast to the ELSI Helpdesk, which provides customized support, the ELSI Knowledge Base is available to the user on a self-serve basis and expected to be fully operable in autumn 2018.
Fiche d'inventaire - Objet n° 7288 - Pieds sur socle
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
فرهنگ های مختلف مصرف انرژی (مورد مطالعه خانوارهای مشهدی)
Publisher: name: دانشگاه کردستان
Year: 2022

description:  امروزه یکی از عوامل آلودگی محیط زیست چگونگی مصرف انرژی در بخش خانگی است. آمار جهانی نیز حاکی از افزایش\nمصرف انرژی در این بخش میباشد. البته مصرف انرژی در بین افراد و خانواده ها به شیوه ها و سبکهای گوناگونی صورت\nمیگیرد که از آن تعبیر به فرهنگهای مختلف مصرف انرژی میشود و این فرهنگ یا فرهنگها تحت تأثیر عوامل مختلفی\nشکل میگیرند. هدف اساسی تحقیق حاضر شناخت فرهنگهای مختلف مصرف انرژی )گاز و برق( در بین خانوارهای\nمشهدی در سال 8931 است. برای رسیدن به این هدف، از روش تحقیق آمیخته یا کمی-کیفی از طریق مصاحبه\nنیمه ساختاریافته با 72 نفردر بخش کیفی و توزیع پرسشنامه در میان 933 نفر در بخش کمی در بین خانوارهای\nمشهدی استفاده شد. براساس نتایج بخش کیفی به طور کلی دو فرهنگ عمده »مُسرف« و »صرفه جو« با هشت خرده\nفرهنگ متفاوت؛ صرفه جوی متعهد، صرفه جوی خودمدارانه، صرفه جوی ناگزیر، مصرفگرای عاطفی ، مصرفگرای نامتوازن،\nمصرفگرای تقلیدی، مصرفگرای جبرانی و مصرفگرای نمایشی ملاحظه شد. نتایج بخش کمی نشان داد که 99/93\nدرصد نمونه جزو فرهنگ مُسرف و 72/04 درصد جزو فرهنگ صرفه جو هستند. 7/78 درصد نمونه اطلاعات زیست محیطی\nاندکی دارند. تحلیلها نشان داد که فرهنگ مسرف در محلات توسعه یافته بیش از محلات کم توسعه است
ALÉM DO CRIME E DAS GRADES VERDE AMARELAS  Um estudo biopsicossocial sobre o crime no Brasil á partir da  analise da população carcerária
Creators: name: Thiago Perez Bernardes de Moraes
Publisher: name: Zenodo
Year: 2013

description: RESUMO: O perfil social da população carcerária é um interessante termômetro da criminalidade brasileira, aqui comparamos os dados carcerários com as teorias biopsicossociais com ênfase na psicologia evolucionista. Analisamos também o índice de Gini e as variáveis estruturais do Brasil contemporâneo. Nossos resultados indicam que parece haver uma forte correlação entre criminalidade e desigualdade social. Nesse sentido, sendo o Brasil uma das nações mais desiguais do planeta, era de se esperar que o índice de criminalidade fosse alto. Segundo, há um padrão quanto ao tipo de criminoso mais frequente: 1)homens, 2)jovens, 3)com baixo nível educacional, tal padrão é convergente com a psicologia evolucionista, considerando que os indivíduos nessa conjuntura, mais do que os demais, são motivados a galgarem estratégias exploratórias de aquisição de recursos, visando como fim inconsciente à aquisição de parceiros sexuais e o exercício da dominância social sobre os demais. Nesse sentido, a segurança dos indivíduos não pode ser garantida somente através do poder coercitivo, antes de tudo, é preciso minar o fosse de desigualdade entre os indivíduos e elevar de alguma forma a equidade social. Entendemos também que o país deve avançar no que diz respeito às condições carcerárias e nas medidas de ressocialização dos detentos, pois no limite a atual situação pode hipertrofiar a organização do crime, ao invés de abolila.  Palavras-chave: Crime, População carcerária brasileira, Psicologia evolucionista.
Fiche d'inventaire - Objet n° 7229A_B - Crochet de litière (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: Relation: Double de 7229A_B
description: IIIF manifest
description: created: 1950/1970
sj-docx-1-wmr-10.1177_0734242X221127170 – Supplemental material for Multiple-criteria decision analysis to substantiate the prospects of industrial and solid municipal wastes as slurry fuel components
Creators: name: Romanov, Daniil
name: Vershinina, Ksenia
name: Nyashina, Galina
name: Strizhak, Pavel
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-docx-1-wmr-10.1177_0734242X221127170 for Multiple-criteria decision analysis to substantiate the prospects of industrial and solid municipal wastes as slurry fuel components by Daniil Romanov, Ksenia Vershinina, Galina Nyashina and Pavel Strizhak in Waste Management & Research
از مکتب تا فرهنگ: تبیین فرایندِ اجتماعی-فرهنگی عیاری و شکل گیری ورزش زورخانه ای در ایران
Publisher: name: دانشگاه کردستان
Year: 2022

description: زورخانه در رهبری فکری نهضت های آزادیبخش و ترویج آداب و آیین فتوّت و کردار جوانمردانه در دوران پرفراز و\nنشیب تاریخ ایران زمین نقش مهمی ایفاء کرده است. بنابراین، این مطالعه در پی تبیین فرایند اجتماعی– فرهنگی عیّاری\nو شکلگیری ورزش یا در واقع مکتب زورخانه ای در ایران است. از حیث روششناسی، رویکرد این مطالعه کیفی است و\nاز روش نظریه داده بنیاد همساخت گرایانه )رویکرد چارمز( استفاده شده است. مشارکت کنندگان این مطالعه )مطلعین\nکلیدی(، پهلوانان صاحب نظر و باسابقه که هم از نظر عملی و هم نظری آشنا به فرهنگ، تاریخ، آداب و رسوم زورخانه و\nهمچنین پژوهشگران دارای سابقه پژوهش در این حوزه بودند که به شیوه نمونه گیری گلوله برفی انتخاب شدند و در\nمجموع نوزده مطلع کلیدی و صاحب تجربه در ورزش زورخانه ای از طریق نمونه گیری کیفی یا هدفمند جذب شدند\nبرای گردآوری داده ها از یک مصاحبه نامه نیمه ساختمند استفاده شده و مصاحبه ها تا حصول به اشباع نظری ادامه یافت.\nیافته های این پژوهش نشان میدهد که میتوان فرایندِ اجتماعی-فرهنگی عیاری و شکل گیری مکتب زورخانه در ایران\nرا در سه خوشه معنایی تبیین و تلخیص کرد: الف( پدیده محوری: کنشها، واکنشها و برهم کنشهای جاری در فضای\nزورخانه؛ ب( عوامل زمینه ای یا شرایط اثرگذار بر کنشها، واکنشها و برهم کنشهای عیاری که بخشی از آنها\nتسهیل کننده و بخشی دیگر بازدارنده آن هستند و ج( مؤلفه های مربوط به پی آیندها و آثار کنشها، واکنشها و برهم\nکنشها در فضای زورخانه که شامل فضای حاکم بر زورخانه، فضای حاکم بر محیط ورزش به عنوان یک محیط بینابین\nو جامعه به عنوان محیط کلان
Fiche d'inventaire - Objet n° 7350 - Torse masculin (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
sj-docx-1-pie-10.1177_09544089221132724 - Supplemental material for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants
Creators: name: Chinnachamy, Rajaganapathy
name: Durairaj, Vasudevan
name: Saravanamuthu, Murugapoopathi
name: Rajagopal, Varthini
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-pie-10.1177_09544089221132724 for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants by Rajaganapathy Chinnachamy, Vasudevan Durairaj, Murugapoopathi Saravanamuthu and Varthini Rajagopal in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Fiche d'inventaire - Objet n° 64SS367 - Clochette à vajra
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Additional file 1 of Comprehensive analysis of genomic complexity in the 5’ end coding region of the DMD gene in patients of exons 1–2 duplications based on long-read sequencing
Creators: name: Shen, Jiandong
name: Ding, Taoli
name: Sun, Xueping
name: Yang, Ji
name: Zhang, Yue
name: Wang, Jing
name: Ge, Mengdi
name: Xu, Heng
name: Xie, Jiazi
name: Wang, Fei
name: Diao, Feiyang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1.
HICSS57 Cybercime minitrack
Creators: name: Siuda, Piotr
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 470101
subject: Communication studies
classificationCode: 470107
subject: Media studies
classificationCode: 470102
subject: Communication technology and digital media studies
classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: The present resource pertains to the “Cybercrime” minitrack held at the 57th Hawaii International Conference on System Sciences (HICSS 2024), which took place in Hawaii, USA, from January 3-6, 2024. This event was organized by the University of Hawaii at Manoa in conjunction with the Shidler College of Business.This resource includes all materials pertinent to the minitrack’s organization, except articles that were either desk rejected or rejected following peer reviews and the reviews’ content. Each submitted article was subjected to a double-blind peer review process, receiving three reviews.The materials encompassed in this resource include:The Call for Papers (CfP) for the minitrack disseminated across multiple channels.Four papers published in the minitrack, including the opening article.The research associated with this resource was funded by the Polish National Science Centre (Narodowe Centrum Nauki) grant, numbered 2021/43/B/HS6/00710.
ضرب المثل های دَری بهدینی زرتشتیان ایران و تأثیر آن بر نقشمایه های هنر زرتشتی دوزی
Publisher: name: دانشگاه کردستان
Year: 2022

description: هنر، محمل مناسبی برای فرهنگ است. زرتشتیان، همواره زندگی مسالم تآمیزی با هموطنان خویش داشته اند. اما به\nواسطۀ آنکه در ساختار و قشر خاص خویش، قواعد و نحوۀ زیستی متفاوتی را تجربه میکرده اند؛ لذا خرده فرهنگ ویژهای\nرا رقم زدهاند که در ضرب المَثَل هایشان رخ نمایی میکند. چرایی به وجود آمدن زرتشتی دوزی در راستای ضرب المثل های\nدَری بهدینی پرسش اصلی این پژوهش میباشد. تأثیر و تأثرات ضرب المَثل های دَری بهدینی به همراه قوانین حاکمۀ عصر\nقاجار، یکی از دلایل شکل گیری این نحوه ی خاص سوزن دوزی سنتی گردید که به هنر »زرتشتی دوزی« شهرت دارد\nهدف اصلی مقاله، پیگیری همانندی ها و تکرار نقش مایه های هنر زرتشتی دوزی با واژه های پراستعمال ضرب المثل های دَری\nبهدینی است. ازآنجاکه ضرب المثل ها، شامل بخش شفاهی فرهنگ اند و گویش دری بهدینی هرگز نوشتار نشده است،\nبه ناچار بخشی از گردآوری اطلاعات بر پایه مصاحبه های میدانی و کتابخانه ای نهاده شد. زرتشتی دوزی مسبب شکلگیری\nاولین نمونۀ هنر تکه دوزی ایرانی، بهنام »تیر و سیخ« گردید. پارچه های »تیر و سیخ« که مزین به هنر زرتشتی دوزی\nمیشد، اغلب در البسۀ مراسم و مجالس سنتی یا آیینی کاربرد داشت. در واقع زرتشتیدوزی، هنر زنانهایست که توسط\nبانوان زرتشتی یزد به ثبت و ضبط فرهنگ خویش پرداخت؛ فرهنگ زرتشتیان نیز که بهنوبۀ خود با نحوۀ زیست و معاش\nایشان ارتباط تنگاتنگ داشت منجر به شکل گیری ضرب المثل های دَری بهدینی شد. این ضرب المثل ها نیز به ترسیم\nواژگانی زیست کشاورزی و شبانی زرتشتیان پرداخته اند. چنانکه کمیت تکرار اسامی مرتبط با شیوۀ زیستی ایشان مشابه\nبا مقدار استعمال و اقبال در انتخاب نقش مایه های موجود در زرتشتی دوزیست
Immune suppressive effects of plasma-derived exosome populations in head and neck cancer
Creators: name: Beccard, Inga J.
name: Hofmann, Linda
name: Schroeder, Jan C.
name: Ludwig, Sonja
name: Laban, Simon Andreas
name: Brunner, Cornelia
name: Lotfi, Ramin
name: Hoffmann, Thomas K.
name: Jackson, Edwin K.
name: Schuler, Patrick
name: Theodoraki, Marie-Nicole
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Tumor-derived exosomes
subject: Immune regulation
subject: HNSCC
subject: DDC 610 / Medicine & health
subject: Squamous cell carcinoma of head and neck
subject: Liquid biopsy
subject: Exosomes
subject: Plattenepithelcarcinom

description: Plasma-derived exosomes of head and neck squamous cell carcinoma (HNSCC) patients carry inhibitory factors mediating immune suppression. Separation of tumor-derived exosomes (TEX) and non-TEX may assist in a better understanding of their respective parental cells. Here, we evaluate the impact of TEX or hematopoietic-derived exosomes on immune suppression. We evaluated apoptosis in CD8+ T cells, conversion of CD4+ T cells to regulatory T cells (Treg), and adenosine production by TEX, non-TEX, or total exosomes. Exosome protein cargo was significantly higher in total and CD45(−) exosomes from high stage compared to low stage patients. Furthermore, total and CD45(−) exosomes of high stage patients induced more apoptosis in CD8+ T cells than their low stage counterparts. CD69 suppression, a marker of reduced CD8+ T cell activation, was only mediated by CD45(−) exosomes. All fractions induced Treg differentiation, defined by CD39 expression, but only CD45(−) exosomes showed a stage-dependent conversion. CD45(−) exosomes produced higher adenosine concentrations than CD45(+) exosomes, concluding that adenosine production measured in total exosomes mainly derives from TEX. The presented results show significant induction of immune suppression by TEX in HNSCC. This immunosuppressive effect supports the potential role of exosomes as liquid biomarkers for disease stage and level of immune suppression.
sj-docx-7-pie-10.1177_09544089221132724 - Supplemental material for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants
Creators: name: Chinnachamy, Rajaganapathy
name: Durairaj, Vasudevan
name: Saravanamuthu, Murugapoopathi
name: Rajagopal, Varthini
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-7-pie-10.1177_09544089221132724 for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants by Rajaganapathy Chinnachamy, Vasudevan Durairaj, Murugapoopathi Saravanamuthu and Varthini Rajagopal in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
کیفیت زندگی و ارتباط آن با عوامل اجتماعی- روانی (مورد مطالعه: زنان سرپرست خانوار شهر شیراز)
Publisher: name: دانشگاه کردستان
Year: 2022

description: مطالعه پیشرو عوامل اجتماعی ـ روانی مرتبط با کیفیت زندگی زنان سرپرست خانوار شهر شیراز را بررسی میکند\nداده های تحقیق حاضر حاصل یک مطالعه پیمایشی است. حجم نمونه مورد بررسی 044 نفر است که با روش نمونه گیری\nخوشه ای چندمرحله ای انتخاب شدند. روش گردآوری داده ها از طریق پرسشنامه بوده است. پرسشنامه مورد استفاده در\nاین پژوهش، ترکیبی از اطالعات جمعیت شناختی، پرسشنامه سرمایه اجتماعی، مقیاس عزت نفس روزنبرگ و پرسشنامه\nکیفیت زندگی است. این پرسشنامه توسط زنان سرپرست خانوار ساکن شهر شیراز پر شده است. داده ها با استفاده از نسخه\n12 نرم افزار SPSS در دو بخش توصیفی و استنباطی مورد تجزیه و تحلیل قرار گرفتند. برای تجزیه و تحلیل داده ها در\nبخش استنباطی از آزمونهای تفاوت میانگین )آزمون T ،)تحلیل واریانس )آزمون F ،)آزمون همبستگی و رگرسیون چند\nمتغیره استفاده شده است. نتایج تحقیق نشان داد که بین متغیرهای تعداد افراد تحت سرپرستی، درآمد، تعداد سالهای\nتحت پوشش در موسسه حمایتی خاص، عزت نفس، انسجام اجتماعی، اعتماد اجتماعی، مشارکت اجتماعی، شبکه اجتماعی\nو سرمایه اقتصادی باکیفیت زندگی زنان سرپرست خانوار رابطة معنادار وجود دارد. همچنین، نتایج تحلیل رگرسیونی نشان\nداد که متغیرهای عزت نفس، اعتماد اجتماعی، انسجام اجتماعی و درآمد، متغیرهای تعداد افراد تحت سرپرستی و تعداد\nسالهای تحت پوشش در موسسه خاص، تعیین کننده های اصلی کیفیت زندگی زنان سرپرست خانوار هستند. در مجموع\nاین متغیرها 35 درصد از واریانس متغیر کیفیت زندگی زنان سرپرست خانوار را تبیین کردند
Additional file 2 of Comprehensive analysis of genomic complexity in the 5’ end coding region of the DMD gene in patients of exons 1–2 duplications based on long-read sequencing
Creators: name: Shen, Jiandong
name: Ding, Taoli
name: Sun, Xueping
name: Yang, Ji
name: Zhang, Yue
name: Wang, Jing
name: Ge, Mengdi
name: Xu, Heng
name: Xie, Jiazi
name: Wang, Fei
name: Diao, Feiyang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2.
Fiche d'inventaire - Objet n° 7316 - Fragment tubulaire (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Fer

description: Source: FCA/3/2
description: Relation: Double de 7316
description: Relation: JFCA, tome 15, p. 63, 10
description: IIIF manifest
description: created: 1950/1970
Macht car2go eine Stadt nachhaltig mobil?
Creators: name: Müller, Martin
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: car2go
subject: DDC 330 / Economics
subject: Sustainability
subject: Carsharing
subject: Mobilität
subject: Online-Publikation
subject: Ringvorlesung

description: In Ulm wird seit dem Jahr 2009 das Carsharing revolutioniert. Überall in Ulm können die 200 Smarts gemietet und abgestellt werden, 19 Cent je Minute kostet ein car2go. Nur welche Wirkungen hat solch ein Konzept für die Nachhaltigkeit in einer Stadt? Der Vortragende hat dieses Projekt wissenschaftlich begleitet und stellt interessante - und zum Teil verblüffende - Ergebnisse daraus vor. Ob und unter welchen Rahmenbedingungen dieses Modell in zukünftigen Verkehrskonzepten eine Rolle spielen kann, wird hier diskutiert.
تبیین جامعه شناختی نسبت بین هویت فرهنگی و مصرف فرهنگی (زنان جوان شاهین شهر)
Publisher: name: دانشگاه کردستان
Year: 2022

description: این پژوهش، باهدف بررسی رابطه هویت فرهنگی با مصرف کاالی فرهنگی در زنان جوان شهر شاهینشهر انجام شد\nچارچوب نظری پژوهش بر اساس هویت فرهنگی و مصرف کالای فرهنگی تنظیم شده است. این مطالعه با روش تحقیق\nکمی و پیمایشی و با استفاده از ابزار پرسشنامه صورت گرفته و از حیث هدف کاربردی و ماهیت همبستگی میباشد\nجامعه آماری تحقیق زنان جوان شهر شاهین شهر بوده و حجم نمونه با توجه به فرمول نمونه گیری کوکران 733 نفر برآورد\nگردید. داده های این تحقیق، بر اساس نمونه گیری طبقه بندی انجام گرفت. روایی پرسشنامه به صورت محتوایی و صوری\nتوسط متخصصین تأیید و احتساب پایایی پرسشنامه با ضریب آلفای کرنباخ محاسبه شد. تجزیه و تحلیل داده ها با\nروشهای آماری در محیط نرم افزار37 Spss و Amos انجام شد. در سطح آمار استنباطی، آزمون کلموگروف – اسمیرنف،\nضریب همبستگی پیرسون و معادلات ساختاری مورد استفاده قرار گرفت. نتایج همبستگی نشان داد که بین هویت فرهنگی\nبا مصرف کالای فرهنگی همبستگی معناداری وجود دارد. تجزیه و تحلیل معادلات ساختاری نشان داد که ابعاد متغیر\nهویت فرهنگی یعنی زبان، دیانت، جغرافیای فرهنگی، تاریخ و حافظه تاریخی، نظام اجتماعی به ترتیب 091 ، /081، /\n718 ، /308 ، /083 /با مصرف کالای فرهنگی در سطح معنی دار 110 /رابطه معنادار وجود دارد. بر اساس نتایج پژوهش\nبا توجه به بستر جامعه میتوان گفت ابعاد هویت فرهنگی بر مصرف کالای فرهنگی تأثیرگذار هستند
Supplemental Material, sj-pdf-1-ajl-10.1177_15598276211052248 - Building Health Equity: Action Steps From the American College of Lifestyle Medicine’s Health Disparities Solutions Summit (HDSS) 2020
Creators: name: Cassoobhoy, Arefa
name: Sardana, Jasmol J.
name: Benigas, Susan
name: Tips, Jean
name: Kees, Alexandra
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental Material, sj-pdf-1-ajl-10.1177_15598276211052248 for Building Health Equity: Action Steps From the American College of Lifestyle Medicine’s Health Disparities Solutions Summit (HDSS) 2020 by Arefa Cassoobhoy, Jasmol J. Sardana, Susan Benigas, Jean Tips and Alexandra Kees in American Journal of Lifestyle Medicine
Additional file 3 of Comprehensive analysis of genomic complexity in the 5’ end coding region of the DMD gene in patients of exons 1–2 duplications based on long-read sequencing
Creators: name: Shen, Jiandong
name: Ding, Taoli
name: Sun, Xueping
name: Yang, Ji
name: Zhang, Yue
name: Wang, Jing
name: Ge, Mengdi
name: Xu, Heng
name: Xie, Jiazi
name: Wang, Fei
name: Diao, Feiyang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 3.
Role of the hypothalamic paraventricular nucleus in the cardiovascular responses to elevations in body temperature
Creators: name: Cham, Joo Lee
Publisher: name: RMIT University
Year: 2024

description: The hypothalamic paraventricular nucleus (PVN) is known to be a major integrative region within the forebrain. It is composed of functionally different subgroups of neurons, including the parvocellular neurons that project to important autonomic targets in the brainstem e.g. the rostral ventrolateral medulla (RVLM) and the intermediolateral cell column (IML) of the spinal cord, where the sympathetic preganglionic motor-neurons are located. These regions are critical in cardiovascular regulation; hence, these projections are likely to mediate the effects of the PVN on sympathetic nerve activity and hence may contribute to the cardiovascular changes induced by physiological stimuli such as elevations in body temperature.

The neurotransmitter such as nitric oxide (NO) is important in cardiovascular regulation and it is now emerging as a major focus of investigation in thermoregulation. One of the most striking accumulations of NO containing-neurons is in the PVN where it appears to be playing an important role in cardiovascular regulation and body fluid homeostasis.

The results of the work show;

1. That spinally-projecting and nitrergic neurons in the PVN may contribute to the central pathways activated by exposure to a hot environment.

2. Suggests that nitrergic neurons and spinally- projecting neurons in the brainstem may make a small contribution to the central pathways mediating the reflex responses initiated by hyperthermia.

3. The present study also illustrates that these PVN neurons projecting to the RVLM may make a smaller contribution than the spinal-projecting neurons in the PVN to the cardiovascular responses initiated by heat.

4. The results of my studies showed that the microinjection of muscimol to inhibit the neuronal activity in the PVN abolished the reflex decrease in renal blood flow following an elevation of core body temperature. In addition, this effect was specific to the PVN, since microinjections of muscimol into areas outside the PVN were not effective. These findings demonstrate that the PVN is critical for this reflex cardiovascular response initiated by hyperthermia.

In conclusion, PVN is critical for the reflex decrease in renal blood flow during elevations in core body temperature. We hypothesise that projections from the PVN to the spinal cord and the RVLM contribute to the reflex cardiovascular responses. Additionally, nitrergic neurons in the PVN may contribute but the physiological role of those neurons in the reflex responses elicited by hyperthermia needs to be investigated.