cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Antioxidant activity of polyphenols from the lichens Hypogymnia tavaresii, Lethariella canariensis and Evernia prunastri
Creators: name: Toledo Marante, Francisco Javier
name: Estévez Rosas, Francisco Jesús
name: Rodríguez Pérez, Elsa María
name: Quintana Aguiar, José Martin
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The secondary metabolites isolated from the lichens H. tavaresii, L. canariensis and E. prunastri have been studied in a bid to find compounds moderately protective against oxidative stress. The phenolic fraction of this lichen displayed superior activity than the antioxidant melatonin against lipid peroxidation in the rat brain homogenate test. The compounds of the active fractions exhibited 180- 8260 fold less radical scavenging activity than the reference substance α-(+)-tocopherol in a DPPH• model expressed by IC50 values (Table 1).1,2,3,4

Table 1. Radical scavenging (DPPH) effects of polyphenols isolated from the lichens H. tavaresii, L. canariensis and E. prunastri.

Polyphenol
 IC50, mmol L-1
 α-(+)-Tocopherol
 7.59±0,25
 Atranorin/ chloroatranorin mixture
 1400.00±4.48
 Chloroatranol
 1475.00±5.00
 Evernic acid
 2730.00±9.51
 Evernin
 2960.00±9.54
 Isophysodic acid
 3782.00±12.10
 Atranol

 2´-O-methyl-physodone
 3960.00±12.67
 Atranorin
 4315.00±13.81
 Physodic acid
 6273.60±20.08
 Methyl hematommate
 6637.80±19.50
 Ethyl hematommate
 6641.00±19.68
 Usnic acid
 9856.15±29.21
 Methyl β-orsellinate
 10159.82±31.96
 Ethyl everninate
 59700.00±13.15
 Methyl everninate
 62700.00±13.81
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Acute N-acetylcysteine supplementation improves severe-intensity continuous cycling performance
Creators: name: Linoby, Adam
name: Bailey, Stephen
name: Willis, Craig
name: Jones, Andrew
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: N-acetylcysteine (NAC) is an antioxidant that can neutralise free radicals, but its impact on exercise performance is controversial. In a balanced crossover design, subjects orally consumed either NAC (70 mg/kg) or placebo (PLC; 70 mg/kg of maltodextrin) 1 hr prior to exercise trial. Following ramp incremental test and familiarization visits, nine subjects completed a severe-intensity constant-work-rate (CWR) trial. Time-to-exhaustion was 12.8 % greater (P = 0.04) with NAC (387 ± 55 s) compared to PLC (343 ± 61 s). Plasma malondialdehyde (MDA) concentration, (measured via high-performance liquid chromatography) was significantly reduced at 4 min during exercise (P = 0.02) and at exhaustion (P = 0.02) compared to PLC. Compared to PLC, the increment of plasma potassium [K+] at 4 min during exercise was significantly attenuated by NAC (P < 0.02). Resting heart rate, systolic and diastolic BP, blood [lactate] and blood [glucose] were not different between NAC and PLC, at individual and across all time points. These preliminary data revealed that NAC may improve severe-intensity exercise performance, with enhanced K+ regulation and improved redox balance a likely mechanism.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Supplementary document for Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina - 6067004.pdf
Creators: name: Liu, Zhuolin
name: Zhang, Furu
name: Zucca, Kelvy
name: Agrawal, Anant
name: Hammer, Daniel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Ophthalmology
Vision Science
Applied Physics
Biomarkers
Optical Physics not elsewhere classified

description: Supplemental Document
Screening and Purification of Metal Chelating Peptides in Hydrolysates  for their Antioxidant Properties
Creators: name: Canabady-Rochelle, Laetitia
name: PARIS, Cédric
name: SELMECZI, Katalin
name: GAUCHER, Caroline
name: LEROY, Pierre
name: ALEM, Halima
name: SCHNEIDER, Raphaël
name: CHAIMBAULT, Patrick
name: MUHR, Laurence
name: BOSCHI-MULLER, Sandrine
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Metal-chelating peptides obtained after protein hydrolysis exhibit antioxidant properties used in pharmaceutics, food or cosmetic. Upon their chelation with transition metals such as Fe(II), the Fenton reaction catalysed by Fe(II) is inhibited. Hence, the production of Reactive Oxygen Species (ROS) is limited. Some illnesses are related to this oxidative stress, in particular inflammatory bowel diseases, with iron anemia complication.

The screening and purification of metal-chelating peptides for their antioxidant properties is a federative project for the Université de Lorraine. Two original screening methods of metal-chelating peptides are currently developed. The first method uses Surface Plasmon Resonance to screen complex mixtures of peptides and to selectively detect the most interesting ones for metal chelating properties. Besides, this method is of high interest for the prediction of separation in immobilized metal ion affinity chromatography.

The second method, based on IMAC coupled to mass spectrometry, aims to quickly screen Fe(II) chelating peptides in complex mixtures of peptides - before starting the separation. Then, the identified iron-chelating peptides could be studied for their antioxidant properties for health applications, among them treatment of ferriprive anemia, or Inversely, hematochromatosis. Such metal chelating peptides could be anchored on nanoparticles either for bioimaging or therapeutic applications.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
D8.5 – Report on the link between MAGIC and EIP AGRI
Creators: name: Spanish Co-Ops
Publisher: name: Zenodo
Year: 2021
Subjects: biomass
Biobased
bio fuels
crops
industrial crops
marginal lands

description: The MAGIC project aims to promote the sustainable development of efficient and beneficial industrial crops on marginal lands. A database and a crop support system have been developed, including detailed agricultural information to be of great use to farmers.
 In addition, marginal lands in Europe have also been analysed and several optimal crops have been proposed with the aim of developing sustainable best practice options for industrial crops. The impact of MAGIC will be maximised by integrating the sustainability aspects (encompassing environment, society, and economy) of value chains.
 Work Package 8- Dissemination and link establishment with EIP AGRI, seeks to propagate the project results, database, maps and DSS tool in order to enhance farmers’ knowledge, plus creating strong links with EIP AGRI.
 This deliverable aims to present the interaction held between MAGIC project, the European Innovation Partnership for Agricultural productivity and Sustainability (EIP-AGRI), and those Operational Groups (OGs) working on related activities. One of the main outcomes of the fruitful interaction among MAGIC partners and the EIP-AGRI was the creation of one Focus Group dedicated to industrial crops.
 In this sense, Spanish Co-ops set the relation between MAGIC project and the EIP-AGRI through the Subgroup of Innovation for agricultural productivity and sustainability (SoI APS), in which this organisation participates representing COPA-COGECA. These interactions allowed to boost MAGIC project dissemination at EIP-AGRI website through the elaboration of a wide set of practice abstracts (PAs), but also to encourage MAGIC partners participation in EIP-AGRI events and activities such as workshops or Focus Groups.
Temple of Ninurta at Nimrud (ancient Kalhu)
Creators: name: Maynard, Glynnis
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The temple of Ninurta is located on the citadel of the Neo-Assyrian city of Kalhu (also known as Nimrud). Kalhu was an imperial capital from 883-706 BCE but had a longer history as an Assyrian city from around 1350 to 610 BCE. The temple was part of a wider architectural landscape of temple complexes and palaces on the citadel, first begun by Ashurnasirpal II (r. 883-859) but sustained and renovated by subsequent Neo- Assyrian kings and local governors. Located at the northern end of the citadel, the temple was immediately north of Ashurnasirpal II’s new palace, southwest of the Ishtar-Sharrat-Niphi temple, and southeast of a ziggurat, which was also dedicated to Ninurta. Although Ashurnasirpal II explicitly states in inscriptions on the temple walls that the structure is a temple to Ninurta, the composite nature of Assyrian deities at the time may have meant that Ninurta shared visual aspects with the Assyrian gods Enlil and Ashur. By the Neo-Assyrian period, Ninurta was a god of war and agriculture. This variability could have been reflected in elements of temple decoration, relief iconography, and cult statues located therein. Archaeological finds from Nimrud are located in museums in Baghdad and Mosul, as well as in at least 74 other museums worldwide. Many archaeological projects have excavated in this area of Kalhu, but the temple itself has not been fully excavated and published architectural plans do not agree upon the relationship of the temple to surrounding structures. Until recently, Ashurnasirpal II’s palace and main temples on the citadel, including the area of the Ninurta temple and ziggurat, were maintained as an archaeological park to encourage tourism and public engagement with the site. However, in 2015 Daesh destroyed the vast majority of unearthed structures on the citadel. Restoration projects are currently underway to recover the site.
Targeting thioredoxin reductase in pancreatic cancer
Creators: name: Al-Hadyan, Khaled
name: Storr, Sarah
name: Inman, Martyn
name: Zaitoun, Abed
name: Lobo, Dileep
name: Moody, Chris
name: Martin, Stewart
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Current treatment options for pancreatic cancer have failed to improve 5-year survival rates which remain very low, at 3.7%; there is an urgent need to identify new treatment modalities. Redox proteins are key members of cellular antioxidant systems, required to maintain redox homeostasis, with the thioredoxin system being an important component. We have developed novel indolequinones (IQs) as thioredoxin reductase inhibitors and are assessing them in pancreatic cancer models as single agents and in combination with ionising radiation. The in vitro cytotoxicity (proliferation and clonogenic survival) of two agents (IQ9 and IQ10) was assessed in PANC-1, MIAPaCa-2 and BxPc-3 pancreatic cancer cell lines. Both agents exhibit potent in vitro cytotoxicity at 24, 48 and 72 hours with IC50 values in the low nM range (~ 90nM at 72h). IC50 doses, either alone or in combination with hydrogen peroxide (H2O2), increase oxidative stress 2 fold as assessed by DCHFDA flow cytometry. IQ treatment results in reduced expression of thioredoxin reducatase, as assessed via Western blotting, with initial data suggesting radiosensitisation of BxPC-3 cells, with a 21% increase in surviving fraction at 2Gray (SF2). Conventional immunohistochemistry experiments are ongoing, examining protein expression of this promising target in pancreatic cancer patient samples.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Reactive oxygen species (ROS) and MyomiRs dysregulation in aged human satellite cells
Creators: name: Di Filippo, Ester Sara
name: Mancinelli, Rosa
name: Pietrangelo, Tiziana
name: Fulle, Stefania
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Sarcopenia is the age-related loss of muscle mass and function. The muscle regeneration is promoted by satellite cells (SC), muscle stem cells. After injury or different stimuli, local signals induce SC proliferation and differentiation for tissue repair, in young subjects.  On the contrary, in elderly subjects, intrinsic stem-cell aging, aging of the niche or systemic environment, induce a reduced SC functionality, determining a difficulty to term the differentiation program1,2. This difficulty could be due to several factors (that may be related to each other) such as oxidative stress accumulation3, failure of the activation of myogenic transcriptional factors (MRFs) together with miRNA deregulation. To achieve this, we investigated in myoblasts and myotubes derived from human Vastus Lateralis skeletal muscle of young and old subjects: i)muscle specific miRNAs (MyomiRs) expression; ii)rtq-PCR for MRFs; iii)O2•- and ROS levels and direct O2•- measurement in mitochondria through MitoSOX™ Red; iv)DYmit after oxidant insult (H2O2); v)Hsp60 and Hsp70 WB. We found deregulation of MRFs and MyomiRs, up-regulation of ROS level, and DYmit decrease in elderly SC. The data obtained suggest an involvement of ROS and specific myomiRs, interfering negatively with myogenic differentiation cooperating to the atrophic state that characterizes muscle ageing.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Potential combination therapy of anticancer drugs with prenylflavonoids
Creators: name: Matouskova, Petra
name: Pešková, Klára
name: Bártíková, Hana
name: Skálová, Lenka
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Plant secondary metabolites as protective dietary agents have become a major topic in human nutrition research. Evidence from epidemiological and human intervention studies is emerging, regarding the protective effects of various (poly)phenol-rich foods against several chronic diseases, including neurodegeneration, cancer and cardiovascular diseases. Prenylflavoniods with potent antioxidant properties, e.g. xantohumol and 8-prenylnaringenin were reported to regulate detoxification enzymes in vitro and xantohumol inhibits the oxidative phosphorylation and induces apoptosis. The presence of the prenyl chain leads to impressive changes in biological activity of flavonoids. The aim of this study was to examine whether a prenylation of naturally occuring flavonoid naringenin could further affect the synergistic interaction when combined with anticancer drugs. We have observed increased cytotoxicity of 6- and 8- prenylnaringenin in comparison to their parent compound naringenin. However, in combination with oxaliplatin the effect in colon cancer cell lines was antagonistic. The drug-drug interactions were analyzed based on the combination index method of Chou and Talalay and the data from NRU assays.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
FROM CHATTING TO MARKETING: THE DEPLOYMENT OF SOCIAL MEDIA FOR MARKETING ACTIVITIES BY STUDENT ENTREPRENEURS
Creators: name: Bernice, Oluwalanu Sanusi, PhD
name: Sunday, Zechariah Olanihun
Publisher: name: SADI Journal
Year: 2024
Subjects: Deployment, social media, marketing activities, student-entrepreneurs, Fountain University Osogbo

description: Social media have assumed a ubiquitous status with its ability to be used making contacts, connections, knowledge, well as businesses. now gone beyond the corporate business world and, especially among. Thus, this study examines the deployment of social media for marketing activities among student entrepreneurs, using Fountain University, Osogbo (FUO). The study was guided by two objectives theoretical background Survey Method was used structured questionnaire was adopted as the instrument of data collection from the 167-sample size of the study through Simple Random Sampling and Purposive Sampling Techniques. Findings of the study revealed that FUO students used social media platforms for marketing activities at least once in a week the most used social media for marketing activities by Facebook, Instagram, Twitter telegram the least used. Also, it was found easy accessibility and profit maximization addition to no or low cost of advertisement among the factors that motivated FUO student entrepreneurs to social media platforms for marketing activities. It is however recommended that further studies to provide more empirical on the of social media for marketing activities among undergraduates, the motivations behind its usage the effects. This could be in of replicating this study its scope expanded to other tertiary across the nation. Tertiary institutions can be selected based on geo-political zones in Nigeria
Supplementary document for Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina - 6067004.pdf
Creators: name: Liu, Zhuolin
name: Zhang, Furu
name: Zucca, Kelvy
name: Agrawal, Anant
name: Hammer, Daniel
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Ophthalmology
Vision Science
Applied Physics
Biomarkers
Optical Physics not elsewhere classified

description: Supplemental Document
Ancient Egyptian Religion in the Early 18th Dynasty
Creators: name: Sartini, Lisa
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The entry gives an overview of the religious beliefs and practices of the Egyptian population at the beginning of the 18th Dynasty, the first dynasty of the New Kingdom (ca. 1550–1070 BCE). During this period, which approximately goes from the reign of the dynasty founder Ahmose to that of Thutmosis III (ca. 1550–1425 BCE), Egypt became a world power, expanding its influence and control in Near East and Nubia through a series of military campaigns. As a consequence, the pharaohs began to control significant wealth, which they largely bestowed on their gods, especially the theban god Amon (also knows as Amon- Ra given its fusion with the sun god Ra). He was elevated to the role of king of the gods and then became the dynastic/state god par excellence.
IMPACT OF PATERNAL AGING ON THE SEMINAL OXIDATIVE STRESS AND SPERM DNA DAMAGE
Creators: name: Dhawan, Vidhu
name: Misra, Swetasmita
name: Biswas, Viplov Kumar
name: Malhotra, Neena
name: Dada, Rima
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Introduction and Objectives: The increase in trend of advanced paternal age and the decline in fecundity as well as adverse reproductive outcomes has increased the awareness of evaluating the DNA integrity in the aging spermatozoa which is vital for the embryonic development. The present study was designed to assess the effect of advanced age on seminal oxidative stress and DNA damage.
 Methods: Semen samples were obtained from 50 male partners of couples with RPL and were grouped into 4 age groups- A (20-25years), B (26-30years). C (31-35years), D (36-40years). Reactive oxygen species (ROS) levels (RLU/sec/million sperm) were assessed by Chemiluminiscence and DNA fragmentation index (DFI) was assessed by sperm chromatin structure assay.
 Results: There was an increase in mean DFI levels (p<0.05) from 33.23±8.91% (group A) to 42.6±6.68% (group D). There was a concomitant increase in ROS levels (p<0.05) from 10.32±3.51 to 83.4±34.3 from group A-D.
Conclusion: Oxidative stress is one of the major causes of defective sperm function, which disrupts the sperm DNA integrity and also limita the fertilizing potential of spermatozoa. This calls for increasing the awareness about the adverse effects of advanced paternal age on DNA integrity.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
SERUM OMENTIN, VISFATIN, VASPIN ARE NOT USEFULL DIAGNOSTIC BIOMARKERS IN COLORECTAL CANCER
Creators: name: Şen, Fatma
name: Erdemli, Hacı Kemal
name: Bademler, Suleyman
name: Ilhan, Mehmet
name: Yavuzer, Hakan
name: Tambas, Makbule
name: Salıs, Osman
name: Kocabas, Ramazan
name: Bedir, Abdulkerim
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Gastrointestinal carcinomas are more prevalent in obese populations compared to nonobese ones. Based on complex interplay between adipokines, obesity is also characterized by increased oxidative stress. Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to development of obesity-related complications. It was found both primary and metastatic carcinomas and may be critical in regulation of the oxidative status of cancer cells. This study investigated the omentin, visfatin and vaspin levels in patients with colorectal carcinomas (CRC).Total of 60 patients with CRC (male/female:25/35) and 30 controls (male/female:15/15) were enrolled. Results were given as median (%95 Cl). Mann-Whitney test was used for the comparison of groups.Serum omentin level was 32.2 (0.3-217.3) ng/L in CRC patients and 34.9 (11.3-123.4) ng/L in control group (P>0.05). Serum visfatin level was 6.8 (2.6-31.9) ng/mL in CRC patients and 9.2 (4.3-26.3) ng/L in controls (P>0.05). Serum vaspin level was 0.7 (0.4-7.6) ng/ml and 1.1 (0.6-4.2) ng/ml in CRC patients and control group, respectively (P>0.05). Serum omentin, visfatin and vaspin levels of CRC patients were not different than those of control group. Thus, serum omentin, visfatin and vaspin levels should not be used as a diagnostic biomarker of CRC.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Data Policy for FESSTVaL campaign data
Creators: name: Sarah, Wiesner
Publisher: name: Universität Hamburg
Year: 2022
Subjects: SAMD
FESSTVAL
FESST

description: Data Policy for FESSTVaL campaign data
 This policy holds for all FESSTVaL campaign data. As it is provided via the SAMD archive, SAMD archive data policy is applicable.
description: Project: FESSTVaL (Field Experiment on submesoscale spatio-temporal variability in Lindenberg), a measurement campaign initiated by the Hans-Ertel-Center for Weather Research.
description: {"references": ["Annika Jahnke-Bornemann, Andrea Lammert, & Felix Ament. (2022, January 19). SAMD: Data Policy for Data USERS (Version 1). http://doi.org/10.25592/uhhfdm.9824"]}
Bifunctional strained cycloalkynes as novel sulfenic acid probes
Creators: name: McGarry, David
name: Shchepinova, Masha
name: Hartley, Richard
name: Olson, Mike
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Reactive oxygen species act as important second messengers in cellular homeostasis through oxidation of protein thiols. However, the dynamic nature of protein oxidation and lack of sensitivity of existing molecular probes has impaired our understanding of such reactions, therefore new tools are required to address these problems. Previous work has demonstrated that strained bicyclo[6.1.0]nonynes (BCN), can be used to label sulfenic acids1. Here, we have designed a bifunctional variant of BCN (BCN-E-BCN) that promotes sulfenic acid labelling and allows for azide tagging using copper-free click chemistry.

 In validation studies, BCN-E-BCN binds the sulfenylated form of the actin severing protein cofilin, whilst mutation of this site abrogates its binding. BCN-E-BCN is cell permeable and reacts rapidly with sulfenic acids in culture cells. Using different azide-conjugated tags, such as azide-biotin and azide-fluorophore, we are able to demonstrate how BCN-E-BCN can be used in a number of applications for the detection of sulfenylated proteins. Remarkably, azide-fluorophore conjugation of BCN-E-BCN labelled proteins can be visualised by fluorescence microscopy to reveal new insights into the localisation of sulfenylated proteins. These findings demonstrate a novel and multifaceted approach into the detection and trapping of sulfenic acids.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Ilex paraguariensis extracts confer lifespan extension in Drosophila melanogaster fed in a high fat diet
Creators: name: Colpo, Ana
name: Lima, Maria Eduarda
name: Rosa, Hemerson
name: Leal, Ana Paula
name: Colares, Chaiane
name: Zago, Ana
name: Bertelli, Paulo
name: Minetto, Luciane
name: Mendez, Andreas
name: Folmer, Vanderlei
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Total energy intake and composition of the diet affect lifespan and ageing. High-fat diet induces oxidative stress, which impacts on development of chronic diseases. In contrast, antioxidants are described as capable to reduce harmful effects. Yerba mate-based beverages are an important source of antioxidants. Here we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster receiving a high cholesterol diet. The LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all extracts examined. In Drosophila under extracts treatment, the mean lifespan was significantly extended from 38 to 43 days, and there was an increase in the ability to resist induced stress (paraquat (p≤0.01); H2O2 (p≤0.05), starvation (p≤0.05) and cold (≤0.05)).  Moreover, Yerba mate extracts recovered the glutathione S-transferase (GST) activity and reduced the cholesterol levels (p<0.001). Yerba mate extracts can promote lifespan extension by reducing the detrimental effect of high fat diet in Drosophila melanogaster and this outcome can be associated with the compound content in extracts. This study can improve our understanding about the natural interventions to reduce oxidative damage produced under certain conditions of stress, which is fundamental to increase life expectancy.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
ROS-mediated regulation of MSC angiogenic activity
Creators: name: Udartseva, Olga
name: Ezdakova, Maria
name: Ratushnyy, Andrey
name: Andreeva, Elena
name: Buravkova, Ludmila
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Mesenchymal stromal cells(MSCs) are promising candidates for cell therapy. However, little is known about regulatory role of ROS in MSCs. In present study we evaluated effects of intracellular ROS on angiogenic activity of MSCs cultured under different oxygen conditions and during long‑term in vitro culture.

 MSCs were isolated from human adipose tissue and maintained in standard or hypoxic oxygen conditions. Senescence was induced by long-term culture of MSCs till 20th passage. ROS was induced by photodynamic treatment(PDT).

We demonstrated that senescence as well as acute hypoxia was accompanied by 2-3-fold increase of intracellular ROS level. No significant changes were found between MSCs cultured under 20% and 5%O2. Long-term culture of MSCs didn’t affect IL-8 and VEGF production while low-fluence PDT resulted in significant increase in IL-8 and VEGF, but not TGF secretion. The PDT effect was less pronounced under acute hypoxia. Then we evaluated the effects of ROS on MSC angiogenic activity using chorioallantoic membrane assay. MSC senescence and acute hypoxia impaired MSC angiogenic activity while PDT promoted angiogenesis via stimulation of tubule complexes and vessels formation. Thus, ROS regulate angiogenic activity of MSCs. However, effects of ROS on MSC activity strongly depend on MSC state.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Writ of the Three Sovereigns also known as “Sanhuang wen”, “三皇文”
Creators: name: Steavu, Dominic
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Writ of the Three Sovereigns was originally a key source of local Southern Jiangnan lore in China during the early medieval period. Dated to around the third century, it collected esoteric techniques that can be traced back to the “masters of methods” (fangshi), regional ritual specialists and influential court advisors from third century BCE to the third century CE. The scripture was thought to have been revealed in Antiquity by high gods to the first three rulers of China, the legendary Three Sovereigns, in order to assist them in ordering the realm and attaining the powers that came with spiritual accomplishment. The bulk of the text is devoted to a series of potent talismans written in a celestial script that is indecipherable to common mortals. When deployed correctly, they can summon supernatural beings ranging from local deities to high-ranking gods so that practitioners can obtain their favor, their protection, or, more commonly, to inquire about future events. The practice has a visualization component since the divine beings manifest in the mind’s eye; accordingly, some scholars term it “visionary divination.” Other techniques that are associated with the scripture include a meditation method that involves generating a bodily god that is a perfect embryonic version of oneself (an enchymoma) and alchemical practices that consist of crafting medicines and elixirs. In the fifth and sixth centuries CE, the Writ of the Three Sovereigns became the centerpiece of one of the three core divisions of the nascent Daoist canon. As a result, it also became one of the foundational sources of early institutional Daoism. This propelled the text from the fairly self-contained context of local Jiangnan lore to a far broader empire-wide setting. The purported efficacy of its summoning techniques, through which, it was rumored, that deities could grant even the status of emperor or empress to practitioners, were quickly identified as potentially seditious by Tang imperial authorities. The scripture was summarily banned in 648 CE. All known copies were collected and destroyed in the capital. The text was replaced in the Daoist canon by the Scripture of the Way and Virtue (Daode jing). Nevertheless, some fragments survived in citations or manuscripts, enough that the Writ of the Three Sovereigns could be reconstructed, at least in part, by contemporary scholars. After the ban, during the Song dynasty (960–1279), the scripture was “rediscovered” as a result of renewed interest in its practices. A highly modified version, in actuality an antiquarian reconstruction, circulated around the tenth century, enjoying significant popularity among Daoists for a few centuries. Its tenets and methods spread throughout China once again. Later on, during the late medieval or early modern periods, the Writ of the Three Sovereigns reached as far as Japan.
RAQAMLI TEXNOLOGIYALARNING TA'LIMDAGI O'RNI VA ROLI
Creators: name: Jurayev, Vohid
name: Komilova, Shahloxon
Publisher: name: Zenodo
Year: 2024

description: Maqolada raqamli texnologiyalarning ta’lim sohasiga kirib borishi va uning imkoniyatlari hamda muammolari haqida so‘z yuritiladi. Raqamli texnologiyalar universitetlar va ta’lim muassasalariga yangi vositalarni taqdim etib, bilim almashish imkoniyatlarini kengaytiradi. Elektron ta’lim tizimi yangi imkoniyatlar yaratadi, lekin shu bilan birga o‘quv mahsulotlari sifatini nazorat qilishning zaifligi, past interaktivlik va sotsializatsiya kabi muammolarni keltirib chiqaradi. Elektron ta’lim rivojlanishi bilan ta’lim xizmatlari bozori tobora globallashib boradi. Maqolada raqamli texnologiyalarning afzalliklari, tahdidlari va ta’lim tizimiga tatbiq etish zarurligini tahlil qilinadi.
Vitamin C oxidation mediates protein aging by oxoaldehyde stress in lens and brain
Creators: name: Monnier, Vincent
name: Fan, Xingjun
name: Sell, David
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Oxoaldehyde stress recently emerged as a major mechanism of damage to cellular and extracellular structures in aging and age-related diseases. The prevailing mechanism invoques methylglyoxal production as a consequence of glycolysis and impairment of arginine residues through the formation of the methyglyoxal hydroimidazolone MG-H1. We have here tested the hypothesis that in tissues rich in ascorbic acid, such as lens and brain, vitamin C can contribute to this damage. MG-H1 quantitated by LC/MS was found several fold increased in lens and brain from transgenic mice expressing the human vitamin C transporter 2 (hSVCT). Immunostaining of MG-H1 was intense in aging and vitamin C incubated human lens proteins and colocalized with neuronal plaques in brain from Alzheimer disease (AD) subjects. MG-H1 levels by LC/MS in AD hippocampus extract were two-four fold increased. Modeling studies and intraventricular injection of 13C-labeled ascorbic acid revealed that ascorbic acid backbone carbons 4-6 were incorporated into MG-H1 in vitro and in vivo, likely via a glyceraldehyde precursor.  The results raise novel and important questions concerning the role of vitamin C in the aging lens and brain.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Construcción social del mercado de trabajo de servicios a las personas: El papel de las mujeres inmigrantes en España
Creators: name: Valencia Olivero, Nelcy Yoly
Publisher: name: Zenodo
Year: 2024

description: La investigación analiza las consideraciones de género presentes en la construcción social del mercado laboral, específicamente en la mercantilización de los trabajos domésticos y de cuidados de personas en España, conocidos como servicios a las personas. Estos trabajos se sitúan en los intersticios de lo formal e informal, lo visible e invisible, y los cuidados y excesos. El estudio combina información cualitativa (30 entrevistas a trabajadoras, 11 a familiares y 3 a técnicos de empleo) y cuantitativa (604 encuestas a mujeres procedentes de Colombia). Se analiza cómo se construye el mercado de trabajo de cuidados en el que participan las mujeres inmigrantes, destacando las desigualdades presentes en dicho mercado laboral. Se examinan sus trayectorias vitales y laborales, identificando elementos que perpetúan las desigualdades basadas en los estereotipos de género en este mercado de trabajo.

El estudio revela que estas trabajadoras enfrentan múltiples tensiones en su entorno laboral, derivadas de ideologías y tradiciones patriarcales, lo que dificulta su integración y movilidad social. A pesar de estas dificultades, las mujeres desarrollan estrategias y habilidades para adaptarse tanto a esquemas formales como informales de trabajo, generando cierto dinamismo en este sector de actividad. Las conclusiones indican que las mujeres que han migrado a España experimentan una falta de conciliación entre su vida personal y laboral, así como una movilidad ocupacional limitada. Se destacan las experiencias de discriminación basadas en género, clase y etnia, y cómo estas afectan su desarrollo y calidad de vida. A pesar de las adversidades, algunas mujeres logran avanzar hacia trabajos más formales y mejor remunerados, buscando ejercer sus derechos y mejorar sus condiciones de vida.

La mercantilización de los trabajos domésticos y de cuidados ofrece una vía para obtener recursos económicos y bienestar, aunque también perpetúa condiciones laborales precarias y feminizadas, que inicialmente son el “motivo para migrar”, pero que con el tiempo se convierten en el “motivo para permanecer” en la sociedad de acogida. Esta decisión está mediada por factores como el conocimiento de una estructura de derechos que pueden ejercer y disfrutar, y la posibilidad de alejarse de eventos de violencia de género en el país de origen. En resumen, la investigación muestra cómo las consideraciones de género y las desigualdades están profundamente entrelazadas en el mercado de trabajo de servicios a las personas, y cómo las mujeres migrantes enfrentan desafíos significativos en su búsqueda de mejores oportunidades laborales y sociales.
Los permisos parentales y los roles de género: estudio de las familias con menores diagnosticados con cáncer
Creators: name: Martín Cabello, Marina
name: García Faroldi, Livia
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2024

description: Los roles tradicionales de género asignan a la mujer la responsabilidad del cuidado de la familia, especialmente en el caso de enfermos, ya sean adultos o menores. No obstante, en los últimos años se está asistiendo a una reconfiguración de los roles paternos y maternos, donde los hombres se implican en el cuidado de sus descendientes. Sin embargo, existe poca investigación previa en nuestro país sobre qué ocurre cuando la enfermedad es de larga duración en un menor e implica unos cuidados prolongados en el tiempo. Este trabajo presenta los resultados de una investigación cualitativa, desarrollada en Málaga. Se realizaron doce entrevistas en profundidad: diez entrevistas a cinco parejas heterosexuales, cuyos descendientes han sido diagnosticados de cáncer, así como a una psicóloga y una trabajadora social que trabajan con menores con dicha enfermedad. Los resultados muestran que, ante la falta de una baja laboral remunerada para ambos progenitores, las madres actúan como cuidadoras principales, incluso si sus ingresos son superiores a los de sus parejas. La prestación por cuidado de menor con enfermedad de larga duración refuerza esta división tradicional de los roles, dado que solamente se concede si ambos trabajan y únicamente uno la solicita. Estos hallazgos ponen de relieve que el permiso debiera diseñarse para ambos progenitores atendiendo al tiempo de enfermedad y recuperación del menor, asegurando una corresponsabilidad real que debilite la asociación de la mujer con el rol de cuidadora.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 9: Addressing family morphogenesis from a relational perspective
Langzeitverfügbarkeit mit Rosetta: ein Werkstattbericht
Creators: name: Riedel, Susanne
name: Peil, Vitali
Publisher: name: Kolloquium Wissensinfrastruktur
Year: 2024

description: Für wissenschaftliche Bibliotheken in NRW ist seit Anfang 2022 durch das Kulturgesetzbuch (KulturGB NRW) vorgesehen, Verfahren zur Langzeitverfügbarkeit (LZV) für digitale Bestände zu etablieren. Die Landesinitiative Langzeitverfügbarkeit (LZV.NRW) baut zu diesem Zweck eine kooperative Infrastruktur auf, die sich an alle NRW-Hochschulen und ihre Bibliotheken richtet. Die UB Bielefeld nutzt  das Angebot der Landesinitiative, das eine Lizenz für die Archivierungssoftware „Rosetta“ sowie Service und Support durch das hbz umfasst.


Im Rahmen des Projekts „Langzeitverfügbarkeit mit Rosetta“ evaluieren UB und Kompetenzzentrum Forschungsdaten die Archivierungssoftware, ein kommerzielles Produkt der Fa. Ex Libris. Es wird getestet, ob die Software dazu geeignet ist, ausgewählte bibliothekseigene Bestände langzeitverfügbar zu machen. Im zweiten Schritt soll ein Dienstleistungsangebot zur Langzeitverfügbarkeit von Forschungsdaten entwickelt werden, das sich an Bielefelder Forschende richtet.
description: Kolloquium Wissensinfrastruktur, Sommersemester 2024
Supplementary document for Quantum limits of position-sensitive photodiodes - 6067052.pdf
Creators: name: Fradgley, Ellie
name: French, Carlton
name: Rushton, Lucas
name: Dieudonné, Yannik
name: Harrison, Lucy
name: Beckey, Jacob
name: Miao, Haixing
name: Gill, Christopher
name: Petrov, Plamen
name: Boyer, Vincent
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Book of Ezekiel
Creators: name: Liebermann, Rosanne
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The book of Ezekiel is one of the prophetic books (Nevi’im) canonized in the Hebrew Bible. It is a text of 48 chapters associated with the sayings and actions of the priest-prophet Ezekiel. Ezekiel is identified as one of the Judean elites exiled by the Neo-Babylonian empire alongside King Jehoiachin of Judah in 597 BCE. The book is set during the period 593-571 BCE and largely reflects the viewpoint of this first group of Judean exiles, who were displaced before the destruction of the Jerusalem temple and additional Judean migrations in 587 BCE. The earliest text of the book of Ezekiel was composed in Hebrew and has been preserved in slightly differing versions: the Masoretic text and fragments from Qumran and Masada in Hebrew, and the Old Greek and an alternative version attested by Papyrus 967 in Greek. The existence of alternative Greek versions of the text indicates that redactional activity on the book of Ezekiel was still taking place at the time of the book’s translation into Greek, probably during the second century BCE. This means that, although many aspects of the book (including its language) reflect its sixth century BCE setting, some parts of it can be attributed to editors from later periods. The text consists of different genres, including narratives about the prophet Ezekiel’s call and sign acts; descriptions of his visions; oracles attributed to the god Yahweh addressed to Judeans in Babylonia and in Jerusalem; and a lengthy law code (chapters 40-48) describing the reconstruction of Yahweh’s temple and the activities that will take place in it. The book of Ezekiel’s primary message is that the Babylonian exile and destruction of Jerusalem are Yahweh’s punishment for the Judeans’ wrongdoing, including their worship of other gods and other cultic transgressions; violent mistreatment of their fellow Judeans; and constantly shifting alliances between foreign nations. Hope for the future is only possible for the Judeans in exile, who have the chance to accept their punishment, continuing to identify as Yahweh’s people and anticipating the day when Yahweh will give them “new hearts and a new spirit” that will allow them (or their descendants) to finally be faithful to him.
title: Examining the Covid-19 Coping Strategies Employed by Residents in Selected South Africa’s Rural Areas
title: N/A
titleType: AlternativeTitle
Creators: name: Okem, Andrew Emmanuel
name: MUBANGIZI, BETTY CLAIRE
name: Adekanla, N
name: John, SF
name: Ibrahima, B
Publisher: name: SPCRD Global Publisihing
Year: 2023

description: N/A
description: Rural communities are vulnerable to shocks associated with the COVID-19 pandemic. The resilience of these communities depends on their ability to cope with the impacts of such shocks. This study examines the COVID-19 coping strategies of residents of Matatiele and Winnie Madikizela Mandela local municipalities in South Africa. We collected primary data through 11 FGDs and 13 individual interviews. Of the six coping strategies identified, the most cited was resorting to alternative food sources to address food insecurity. Other coping strategies include alternative sources of income; reducing remittance and expenditure; shifting to new activities; and introducing emotional support. The findings reveal that coping strategies entail changes around basic needs such as food and income. To protect these communities against future shocks, strong local institutions working in collaboration will be invaluable in empowering communities to identify and implement alternative livelihoods while building supportive infrastructure.
Prozessintensivierung der Ammoniaksynthese im Kontext der Power-to-X Technologie: Das Potential aktiverer Katalysatormaterialien
Creators: name: Cholewa, Thomas
name: Salem, Ouda
name: Schaadt, Achim
name: Güttel, Robert
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2021

description: Die Ammoniaksynthese aus regenerativem, elektrolytisch gewonnenem Wasserstoff (H2) und Stickstoff (N2) aus der Luft im Rahmen des sogenannten Power-to-Ammonia (NH3) Prozesses vermeidet die H2 Gewinnung aus fossilen Energieträgern und reduziert somit die CO2 Emission des Prozesses. Auf diese Weise gewonnenes NH3 kann neben dem Einsatz in der Düngemittelindustrie perspektivisch auch als vielseitiger Energieträger, beispielsweise in Verbrennungsmotoren für Schiffe [1] oder in Verbindung mit einer Reformierung als H2-Trägermolekül [2] eingesetzt werden. Durch die Nutzung von regenerativ erzeugtem H2 als Edukt für die Ammoniaksynthese ergeben sich neue Anforderungen an den Prozess. Hierzu zählen die fluktuierende Bereitstellung von erneuerbaren Energien sowie die reduzierte Produktionsskala im Vergleich zu fossil-basierten Haber-Bosch Prozessen im Gigatonnen-Maßstab [3]. Um die Ammoniaksynthese unter diesen Rahmenbedingungen zu realisieren, werden verschiedene Prozessintensivierungsstrategien diskutiert. Das Ziel der Entwicklung ist ein Prozess mit reduzierter Anlagen- und Apparategröße, der eine dynamische Synthese aus elektrolytisch gewonnenem H2 ermöglicht [4]. Einen vielversprechenden Ansatz zur Prozessintensivierung stellt die sorptionsgestützte in situ Abtrennung von NH3 dar, welche das Potential bietet die thermodynamische Gleichgewichtslimitierung zu überwinden [5]. Grundlegend für die technische Realisierung eines solchen Verfahrens ist es, die Temperatur der Reaktion zu reduzieren um für die sorptive Abtrennung technisch nutzbare Bedingungen zu erreichen. Im Rahmen des Vortrags soll aufgezeigt werden, wie durch die Verwendung aktiverer Katalysatormaterialien die Synthese unter milderen Reaktionsbedingungen und somit thermodynamisch günstigeren Bedingungen realisiert werden kann. Ein hierfür geeigneter Ruthenium Katalysator wird auf experimenteller und simulativer Ebene untersucht, mit dem Ziel ein geeignetes reaktionskinetisches Modell unter milden Reaktionsbedingungen zu bestimmen. Erste experimentelle Ergebnisse der Katalysatoruntersuchung und deren Nutzung für die Modellvalidierung werden diskutiert. Ausblickend wird das Potential Ruthenium-basierter Katalysatoren für die Entwicklung des angestrebten dynamischen und intensivierten Power-to-Ammonia Prozess betrachtet.
Supplementary material for Beneficial Microbes: The associations of pre-pregnancy BMI and gestational weight gain with maternal gut microbiota
Creators: name: He, Y.
name: Zhang, L.
name: Chen, Z.
name: Chan, P.K.S.
name: Leung, T.F.
name: Tam, W.H.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 320209
subject: Gastroenterology and hepatology
classificationCode: 321502
subject: Obstetrics and gynaecology

description: Previous studies reporting the association between gut microbiota dysbiosis and maternal obesity were mostly confined at the phylum level or at postpartum period. This study aimed to investigate the dynamic changes in gut microbial communities associated with maternal obesity at different time points of pregnancy. We performed 16S rRNA gene V3-V4 amplicon sequencing on stool samples from 110 women in all three trimesters and 1-month postpartum. Maternal gut microbial communities associated with maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) were explored. The influence of maternal obesity on gut microbiota trajectories was determined based on longitudinal shifts in community clusters across the trimesters. The richness index of alpha diversity decreased with the progression of pregnancy, particularly in women with excessive GWG. The evenness index in 2nd trimester was found inversely associated with GWG. Various taxonomic differences in 1st trimester were associated with excessive GWG, whereas limited taxonomic differences in 2nd and 3rd trimesters were associated with pre-pregnancy BMI or GWG. Meanwhile, the gut microbiota trajectory with especially depleted genus Faecalibacterium in 1st trimester was associated with excessive GWG (adjusted odds ratio 5.7, 95% confidence interval 1.2-28.1). Moreover, the longitudinal abundances of genus Lachnospiraceae ND3007 group across gestations were depleted in women with overweight/obese pre-pregnancy BMI, while genus Bifidobacterium enriched in women with excessive GWG. Our study shows that dysbiosis of the gut microbiota in early pregnancy may have a significant impact on excess GWG. The abundance of the genus Faecalibacterium in 1st trimester may be a potential risk factor.Clinical trial number: NCT03785093 (https://classic.clinicaltrials.gov/ct2/show/NCT03785093)