cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Energy Dependence of Cu L2,3 Satellites using Synchrotron Excited X-ray Emission Spectroscopy
Creators: name: Magnuson, M.
name: Wassdahl, N.
name: Nordgren, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The L2,3 X-ray emission of Cu metal has been measured using monochromatic synchrotron radiation. The self-absorption effect in the spectra is shown to be very small in our experimental geometry. From the quantitative analysis of spectra recorded at different excitation energies, the L3/L2 emission intensity ratio and the partial Auger-width are extracted. High-energy satellite features on the L3 emission line are separated by a subtraction procedure. The satellite intensity is found to be slowly increasing for excitation energies between the L3, L2 and L1 core-level thresholds due to shake-up and shake-off transitions. As the excitation energy passes the L2 threshold, a step of rapidly increasing satellite intensity of the L3 emission is found due to additional Coster-Kronig processes.
description: 8 pages, 3 figures, http://link.aps.org/doi/10.1103/PhysRevB.56.12238
Secure and Energy-Efficient Data Aggregation in Wireless Sensor Networks
Creators: name: Sen, Jaydip
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cryptography and Security (cs.CR)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Data aggregation in intermediate nodes (called aggregator nodes) is an effective approach for optimizing consumption of scarce resources like bandwidth and energy in Wireless Sensor Networks (WSNs). However, in-network processing poses a problem for the privacy of the sensor data since individual data of sensor nodes need to be known to the aggregator node before the aggregation process can be carried out. In applications of WSNs, privacy-preserving data aggregation has become an important requirement due to sensitive nature of the sensor data. Researchers have proposed a number of protocols and schemes for this purpose. He et al. (INFOCOM 2007) have proposed a protocol - called CPDA - for carrying out additive data aggregation in a privacy-preserving manner for application in WSNs. The scheme has been quite popular and well-known. In spite of the popularity of this protocol, it has been found that the protocol is vulnerable to attack and it is also not energy-efficient. In this paper, we first present a brief state of the art survey on the current privacy-preserving data aggregation protocols for WSNS. Then we describe the CPDA protocol and identify its security vulnerability. Finally, we demonstrate how the protocol can be made secure and energy efficient.
description: 7 pages, 3 figures. In Proceedings of the 2nd National Conference on Computational Intelligence and Signal Processing (CISP 2012), March 2- 3, Guwahati, India.(IEEE Technically Sponsored)
Composition, environmental stability and potential of genetic improvement of fatty acids of Lupinus angustifolius
Creators: name: Beyer, Helene
name: Jürgens, Hans-Ulrich
name: Jansen, Gisela
name: Uptmoor, Ralf
name: Ordon, Frank
Publisher: name: Journal of Applied Botany and Food Quality
Year: 2015
Subjects: fatty acid composition, oil content, narrow-leafed lupin, heritability, variability, environmental stability

description: In the last decades procedures for obtaining protein isolates and concentrates derived from narrow-leafed lupins (L. angustifolius) for human nutrition have been developed. Since this processes starts with defatting of seeds, lupin oil is obtained in large quantities. Therefore, 50 genotypes of L. angustifolius were analysed regarding the fatty acid (FA) composition of seed oil and the environmental stability of fatty acid contents in order to get information on the application of lupin oil in the food industry. The results revealed an n-3/n-6 poly unsaturated fatty acid ratio of 0.13. Furthermore, the seed oil of L. angustifolius contains rather high amounts of saturated FAs (22%). Significant genotypic differences and a high heritability (h2>85%) for the content of all fatty acids are suggesting that the potential for genetic improvement of fatty acid composition by breeding is given. However, coefficients of variation below 10% for all considered traits point out that a rapid improvement in seed oil quality will be hindered by the narrow genetic base of the breeding material tested.
description: Journal of Applied Botany and Food Quality, Vol 88 (2015), p. 192-196
Normative data for COGITAB: An Italian tablet-based test battery conceived for the preclinical phase of Alzheimer’s disease
Creators: name: Beltrami, Daniela
name: Barletta-Rodolfi, Caterina
name: Bertini, Flavio
name: Braglia, Luca
name: Calzà, Laura
name: Corbo, Massimo
name: Gasparini, Federico
name: Marti, Alessandro
name: Montesi, Danilo
name: Pisano, Marta
name: Rusconi, Maria Luisa
name: Sozzi, Matteo
name: Tonon, Cecilia
name: Ghidoni, Enrico
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: The number of people with dementia is increasing worldwide. Two main approaches have been adopted to identify subjects with Alzheimer’s disease (AD): the neuropsychological evaluation and the identification of biomarkers of AD. The first method is less invasive and easier to perform. This study assesses the psychometric properties of COGITAB, a novel web application d esigned to be sensitive to the subtle cognitive changes distinctive of the early Mild Cognitive Impairment (MCI) and the preclinical phase of AD. We enrolled 518 healthy controls, classified according to several risk factors and the presence of a family history of dementia. The participants were given COGITAB after a neuropsychological screening. The COGITAB Total Score (TS) was significantly affected by age and years of education. Acquired risk factors and family history of dementia significantly impacted only the COGITAB total execution time (TET), not the TS. This study provides normative data for a newly developed web application. Control subjects with acquired risk factors performed slower, giving an important role to the TET recording. Further studies should examine the ability of this new technology to discriminate between healthy subjects and subjects with initial cognitive decline, even when not detected by standard neuropsychological assessments.
Role of Hepatic ROS in the Development of Obesity, Steatosis and NAFLD.
Creators: name: SUPREET KAUR
Publisher: name: Monash University
Year: 2019
Subjects: Biochemistry

description: Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), involve excess generation of reactive oxygen species (ROS). An imbalance in ROS generation and elimination has been linked to the development of NAFLD, but the precise mechanisms are not clear. This body of research redefines the role of ROS in the pathogenesis of NAFLD and demonstrates a protective role for ROS in NAFLD pathogenesis.
Conquer the fine structure splitting of excitons in self-assembled InAs/GaAs quantum dots via combined stresses
Creators: name: Wang, Jianping
name: Gong, Ming
name: Guo, Guang-Can
name: He, Lixin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Eliminating the fine structure splitting (FSS) of excitons in self-assembled quantum dots (QDs) is essential to the generation of high quality entangled photon pairs. It has been shown that the FSS has a lower bound under uniaxial stress. In this letter, we show that the FSS of excitons in a general self-assembled InGaAs/GaAs QD can be fully suppressed via combined stresses along the [110] and [010] directions. The result is confirmed by atomic empirical pseudopotential calculations. For all the QDs we studied, the FSS can be tuned to be vanishingly small ($
description: 4 pages, 3 figure, 1 table
Quark Number Susceptibility and Thermodynamics in HTL approximation
Creators: name: Haque, Najmul
name: Mustafa, Munshi G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In HTL perturbation theory we obtain leading order quark number susceptibility as a response to an external disturbance, viz., chemical potential (μ) that generates density fluctuation, which is related to the correlation function through the thermodynamic sum rule associated with the symmetry of the system. We also obtain various thermodynamic quantities in leading order.
description: 4 pages, 2 figures, Talk given at the 6th ICPAQGP-2010, Goa, India, December 6-10, 2010
Structural and Functional Studies of Plasmin Inhibitors
Creators: name: GUOJIE WU
Publisher: name: Monash University
Year: 2019
Subjects: subject: 30406 Proteins and Peptides
subject: FOS: Chemical sciences
subject: Biophysics
subject: 60112 Structural Biology (incl. Macromolecular Modelling)
subject: FOS: Biological sciences
subject: Biochemistry

description: Human plasmin is a plasma serine protease that plays key roles in fibrinolysis, wound healing and cell migration. Accordingly, anti-fibrinolytics targeting plasmin have been widely used for treating life-threatening bleeding during surgeries or in trauma. However, current plasmin-targeting drugs are limited by poor potency or low specificity. Our researcher here characterized the functions and structures of different plasmin specific inhibitors and illustrated the inhibition mechanisms mainly via X-ray crystallography. This work revealed distinct structural features of plasmin active-site within the serine protease family, and developed highly selective plasmin inhibitors, which rationalizes structure-aided drug design and future clinical studies.
Shocking Tails in the Major Merger Abell 2744
Creators: name: Owers, Matt S.
name: Couch, Warrick J.
name: Nulsen, Paul E. J.
name: Randall, Scott W.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We identify four rare "jellyfish" galaxies in Hubble Space Telescope imagery of the major merger cluster Abell 2744. These galaxies harbor trails of star-forming knots and filaments which have formed in-situ in gas tails stripped from the parent galaxies, indicating they are in the process of being transformed by the environment. Further evidence for rapid transformation in these galaxies comes from their optical spectra, which reveal starburst, poststarburst and AGN features. Most intriguingly, three of the jellyfish galaxies lie near ICM features associated with a merging "Bullet-like" subcluster and its shock front detected in Chandra X-ray images. We suggest that the high pressure merger environment may be responsible for the star formation in the gaseous tails. This provides observational evidence for the rapid transformation of galaxies during the violent core passage phase of a major cluster merger.
description: 7 pages, 3 figures. Accepted for publication in ApJL
A biochemical characterisation of the MACPF/CDC pore assembly
Creators: name: BRADLEY ALAN SPICER
Publisher: name: Monash University
Year: 2019
Subjects: Biochemistry

description: The blood plasma contains vital immune proteins for defending against bacteria. This thesis determines high-resolution structures of a giant pore forming protein in the plasma called the Membrane Attack Complex (MAC). Furthermore, a biochemical examination provides a mechanism of how MAC proteins assemble, and an improved understanding of the immune system.
H2M Survey Questionnaire For The Identification Of Commercialisation Training Needs Of Health Researchers
Creators: name: Altsitsiadis, Efthymios
name: Toptsidou, Maria
name: Bougiouklis, Kostas
Publisher: name: Zenodo
Year: 2015
Subjects: health
life sciences
commercialisation
health researchers
training needs analysis
questionnaire

description: Health-2-Market was a 3-year long Coordination and Support Action, funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration (Grant Agreement No 305532). H2M aimed at providing training and individual support to Health / Life Sciences researchers in the process of translating their research results into successful new business ideas.

With a view to properly adapting the training offer of the project to the needs of Health / Life Sciences researchers in terms of entrepreneurship and business skill development a Training Needs Analysis (TNA) was conducted. In this context, H2M launched an online survey targeted at Health / Life Sciences researchers who have been involved in EU health projects. In particular, the objectives of the survey were:

	To formulate  a  descriptive  understanding  of various  aspects  of  commercialisation  and  training  needs  of  the main target group of the project;
	To divide this target group into homogeneous sub-groups (clusters) along a number of key characteristics such as demographics, commercialisation attitudes and needs;
	To understand preferences and importance of different aspects and needs through the analysis of:

		Knowledge  areas  that  can  influence  commercialisation behaviour;
		Training modalities  that  have  an  effect  on  the  intention  to participate and /or on the perception of the usefulness of a commercialisation training;
		Variations identified over different sub-groups.

The survey was dispatched to a database composed of 7,991 unique contacts of participants in previous health projects, accessed through the Directorate General for Health and Food Safety of the European Commission. The initial aim of at least 50 complete responses was overwhelmingly surpassed: 637 respondents completed the survey in full.

The “H2M survey questionnaire for the identification of commercialisation training needs of Health Researchers” document contains the questionnaire that was utilised in the frame of the survey.
GEOMORPHOLOGICAL AND GEOARCHAEOLOGICAL ELEMENTS AS GEOINDICATORS FOR THE EVALUATION OF RECENT VERTICAL MOTIONS ALONG THE CAMPANIA COASTLAND
Creators: name: Stanislao, Corrado
name: Pennetta, Micla
name: Donadio, Carlo
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
Investigating the regulation of mitophagy in the yeast Saccharomyces cerevisiae
Creators: name: KAREN LOUISE DAWSON
Publisher: name: Monash University
Year: 2018
Subjects: Biochemistry

description: When stressed, yeast cells react by turning on signalling pathways to selectively degrade mitochondria. This is an important process for cells to survive. If this process does not function correctly, in humans, this could lead to diseases such as Parkinson’s disease and cancer. This thesis investigated the degradation of mitochondria in yeast cells to better understand this process. Two proteins were shown to influence this pathway, likely by affecting the cell wall. The correct positioning of mitochondria near the cell wall was also shown to influence this degradation process.
Altered learning and transfer abilities in Korsakoff’s syndrome depending on task complexity
Creators: name: Ulasoglu-Yildiz, Cigdem
name: Yildirim, Zerrin
name: Myers, Catherine E.
name: Gluck, Mark A.
name: Gurvit, Hakan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Korsakoff’s syndrome (KS) is characterized by episodic memory impairment due to damage to the medial diencephalic structures. Although commonly associated with chronic alcoholism, starvation due to the hunger strike is one of its nonalcoholic causes. Learning the stimulus-response associations and transferring the just-learned associations to novel combinations were previously tested by specific tasks in memory-impaired patients with hippocampal, basal forebrain, and basal ganglia damage. To add to this previous research, we aimed to use the same tasks in a group of patients with hunger strike-related KS presenting a stable isolated amnestic profile. Twelve patients with hunger strike-related KS and matched healthy controls were tested in two tasks varying in task complexity. Each task included two phases: the initial phase is feedback-based learning of (simple vs. complex) stimulus-response associations, and the following phase is transfer generalization (in the presence vs. absence of feedback). On a task involving simple associations, five patients with KS failed to learn the associations, while the other seven patients showed intact learning and transfer. On the other task involving more complex associations, seven patients showed slower learning and failed at transfer generalization, whereas the other five patients failed even at the acquisition phase. These findings of a task-complexity-related impairment on associative learning and transfer represent a distinct pattern from the spared learning but impaired transfer previously observed on these tasks in patients with medial temporal lobe amnesia.
The Role of ABCA12 in Type 2 Diabetes
Creators: name: GLORIA MARIA ANGELA URSINO
Publisher: name: Monash University
Year: 2018
Subjects: Biochemistry

description: Diabetes is a widespread metabolic disease that occurs when the body cannot control its blood glucose concentration due to dysfunction or absence of pancreatic β-cells. This thesis examines the role of the lipid transporter ABCA12 in β-cells. β-cells secrete insulin to lower blood glucose concentration, and their function is important for the prevention of diabetes. Using a genetically engineered mouse lacking ABCA12 specifically in the β-cell, I uncovered how loss of this protein affects the organisation of cholesterol to control insulin granule morphology and secretion, as well as how it controls the levels of potentially toxic lipid species in β-cells.
Filtered Lie conformal algebras whose associated graded algebras are isomorphic to that of general conformal algebra $gc_1$
Creators: name: Su, Yucai
name: Yue, Xiaoqing
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Algebra (math.QA)
subject: Mathematical Physics (math-ph)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 17B10, 17B65, 17B68

description: Let $G$ be a filtered Lie conformal algebra whose associated graded conformal algebra is isomorphic to that of general conformal algebra $gc_1$. In this paper, we prove that $G\cong gc_1$ or ${\rm gr\,}gc_1$ (the associated graded conformal algebra of $gc_1$), by making use of some results on the second cohomology groups of the conformal algebra $\fg$ with coefficients in its module $M_{b,0}$ of rank 1, where $\fg=\Vir\ltimes M_{a,0}$ is the semi-direct sum of the Virasoro conformal algebra $\Vir$ with its module $M_{a,0}$. Furthermore, we prove that ${\rm gr\,}gc_1$ does not have a nontrivial representation on a finite $\C[\partial]$-module, this provides an example of a finitely freely generated simple Lie conformal algebra of linear growth that cannot be embedded into the general conformal algebra $gc_N$ for any $N$.
The Recognition of Nectin (like) Ligands by Natural Killer Cell Receptors
Creators: name: FELIX ALEXANDER DEUSS
Publisher: name: Monash University
Year: 2018
Subjects: subject: Structural Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110707 Innate Immunity

description: This thesis explores the three-dimensional structures of a family of immune receptors known as the Nectin receptors. Recently, the Nectin receptors have been in the spotlight for their ability to control cancer. The results presented here shed light on the molecular basis behind their function and provide a platform for the development of novel anti-cancer therapeutics.
THE SCALE FACTOR IN THE GRAVITATIONAL MODELING OF LANDSCAPE : THE EXAMPLE OF THE CENTRAL APENNINES (ITALY)
Creators: name: Aringoli, Domenico
name: Gentili, Bernardino
name: Materazzi, Marco
name: Pambianchi, Gilberto
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
The role of the 3’ untranslated region in breast cancer
Creators: name: ANDREW PATTISON
Publisher: name: Monash University
Year: 2018
Subjects: subject: Cancer
subject: Biochemistry
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Our genes and the way in which our genetic code is read makes us who we are. Unfortunately, our genetic code can be altered or misinterpreted in cancer. The 3’ untranslated region is one such example of an important part of our genetic code that is read differently in cancer. This thesis focused on defining what changes to the 3’ untranslated region occur in breast cancer, then explored which of these changes were most associated with breast cancer outcome. Extension and validation of the work in this thesis may one day lead to a better test for breast cancer outcome.
GEOMORPHOLOGICAL EVOLUTION AND HUMAN SETTLEMENT OF THE SABAUDIA LAKE (TYRRHENIAN SEA, CENTRAL ITALY)
Creators: name: Aringoli, Domenico
name: Erbacci, Federica
name: Farabollini, Piero
name: Giacopetti, Marco
name: Materazzi, Marco
name: Pambianchi, Gilberto
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
title: Preservation of viruses
Creators: name: Illango, James
Publisher: name: The University of Edinburgh
Year: 1983
Subjects: subject: Annexe MSc Digitisation Project 2022 Block 51
subject: Dermatophilus congolensis
subject: Hypersensitivity
subject: D.N.C.B. (l-chloro-2, 4-dinitrobenzene)
subject: Rats and guinea-pigs
subject: Cell mediated response

description: A growing need exists for a better method of preservation and maintenance of virus characteristics and properties for use as seed stocks or reference agents, preservation of potencies of vaccines in the present increased application of vaccination programmes for disease-control in many countries. Two main forms of virus preservation, freezing and freeze-drying, were studied using Sendai virus. The survival and maintenance of virus activity were tested by its ability to grow in embryonated hen eggs. These were detected by haemagglutination tests of the allantoic fluids harvested 72 hours after inoculation. There was a loss of virus activity following the freeze-drying method. Electron microscopy revealed disruption of virus particles of the freeze-dried samples. Attention is drawn to the implication of these findings in the preservation of virus vaccines.
Detecting Attention Deficit Hyperactivity Disorder and its feigning using the Personality Assessment Inventory
Creators: name: Maffly-Kipp, Joseph
name: Morey, Leslie C.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Attention Deficit Hyperactivity Disorder is a relatively common and often disabling disorder in adults. However, feigning ADHD symptomatology is both easy and potentially common. We explored the most effective strategies for A) identifying individuals who had been diagnosed with ADHD based on existing PAI symptom indicators, and B), discriminating between feigned and genuine ADHD symptoms using PAI negative distortion indicators. Our sample consisted of 463 college aged participants who had been diagnosed with ADHD (n = 60), were asked to feign ADHD (n = 71), and a control group (n = 333). Self-reported diagnosis and successful feigning were corroborated by the CAARS-S: E scale. We first compared two PAI-derived ADHD indicators to determine which best differentiated between our ADHD and Control groups. Next, we compared seven negative distortion indicators to determine which could best distinguish between real and feigned ADHD symptoms. Our results revealed that the PAI-ADHD scale was the most effective symptom indicator. Further, the Negative Distortion Scale (NDS) and the Item-FAA scale were the most effective for identifying feigners. When assessing ADHD based on the PAI, the PAI-ADHD scale appears promising as an indicator of symptomatology, while the NDS and Item-FAA appear useful to rule-out feigning.
The importance of level statistics for the decoherence of a central spin due to a spin environment
Creators: name: Brox, Håkon
name: Bergli, Joakim
name: Galperin, Yuri M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the decoherence of a central spin-1/2 due to a closed environment composed of spin-1/2 particles. It is known that a frustrated spin environment, such as a spin glass, is much more efficient for decoherence of the central spin than a similar size environment without frustration. We construct a Hamiltonian where the degree of frustration is parametrized by a single parameter $κ$. By use of this model we find that the environment can be classified by two distinct regimes with respect to the strength of level repulsion. These regimes behave qualitatively different with respect to decoherence of the central spin and might explain the strong enhancement of decoherence observed for frustrated environments.
description: 9 pages, 10 figures
Regulation of breast cancer metastasis by G-CSF
Creators: name: KELLIE ANN MOUCHEMORE
Publisher: name: Monash University
Year: 2018
Subjects: subject: Cancer
subject: 110709 Tumour Immunology
subject: FOS: Clinical medicine

description: Treatment options are limited for breast cancer patients whose cancer has spread to other organs. The spreading of tumour cells can be promoted by certain immune cells, therefore this thesis examines how this occurs. It characterises how a treatment designed for inflammatory conditions such as arthritis may also benefit breast cancer patients. This treatment reduces these villain-like immune cells without increasing the risk of infection.
A functional and structural investigation of the pro- and anti-viral roles of the DDX3 DEAD-box RNA helicases
Creators: name: STEVEN MATTHEW HEATON
Publisher: name: Monash University
Year: 2018
Subjects: subject: Biochemistry
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 30406 Proteins and Peptides
subject: FOS: Chemical sciences
subject: 60108 Protein Trafficking
subject: 60111 Signal Transduction
subject: 60112 Structural Biology (incl. Macromolecular Modelling)
subject: 110707 Innate Immunity
subject: FOS: Clinical medicine

description: During infection, our immune system triggers drastic but highly regulated changes in gene activity to bring about protective immune responses. This thesis identifies, dissects and challenges the molecular mechanisms by which DDX3 interacts with the cell nucleus and controls the two main signalling and effector arcs of the human innate immune system. Several incurable viruses weaponise DDX3 and thereby hack into a nexus of immune and other cellular functions to service their own replication; we now adapt this concept and turn it against these very viruses to develop new treatments.
Structural characterisation of molecular interactions in the RIG-I antiviral signalling pathway
Creators: name: NEELAM SHAH
Publisher: name: Monash University
Year: 2018
Subjects: Structural Biology

description: The innate immune system serves to detect foreign infectious pathogens as a first line of the body's defence. After microbes, such as viruses, overcome the physical and chemical barriers, various cells in our body are capable of detecting these infectious viruses. These cells initiate a set of reactions generally known as antiviral innate immune responses. Several proteins within the cell, such as RIG-I like receptors, detect the virus-derived molecules and initiate a signalling cascade. This results in the production of antiviral cytokines such as type I interferons (IFN) and subsequent enzymes for impairing viral replication and resolving viral infection.
Articulation of cognitive-behavioral therapy and neuropsychology: A scoping review
Creators: name: Lopes, Fernanda Machado
name: Fritzen, Brena Hennemann
name: Antunes, Giulia Truppel
name: Marcondes, Mariana Valença
name: de Mendonça, Bárbara Thais Veras
name: Dias, Natália Martins
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy
Mental Health

description: Cognitive-behavioral therapy (CBT) and neuropsychology are areas of psychology that have a common focus of interest on cognitive processing. The present study aimed to map and describe in a systematic way information about the association between CBT and neuropsychology by means of a scoping review. The systematic search for empirical articles published between 2010 and 2020, without language restriction, was carried out in the Medline, PsycInfo, LILACS, and SciELO databases. We found 3,723 articles, of which 198 were duplicates, which were excluded, and 3,525 articles went on to double-blind screening. For full text reading, we selected 323 articles, while 143 of them were selected for analysis. Results showed the characteristics, methodological aspects, and possible associations identified in the studies, which were as follows: neuropsychological assessment (NPA) and CBT assessment; NPA and CBT intervention; neuropsychological intervention and CBT intervention; and CBT strategy in neuropsychological intervention. The most used interventions were classic CBT, rehabilitation, and cognitive training, with the use of psychoeducation, cognitive restructuring, and problem solving, among others, applied, on the whole, to psychiatric and neurological conditions. We conclude that a greater understanding of the possible connections between the two areas can benefit patients from the psychiatric and neurological clinic.
SEISMIC RESPONSE OF THE NEAR SURFACE QUATERNARY DEPOSITS IN AN AREA BETWEEN THE VENETIAN PRE-ALPS AND THE LAGOON OF VENICE (NORTHEASTERN ITALY)
Creators: name: Bondesan, Aldino
name: Francese, Roberto
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
The Comparative Effects of Endogenous, Synthetic and Selective Glucocorticoids during Lung Development
Creators: name: BENNET KIM LEE SEOW
Publisher: name: Monash University
Year: 2018
Subjects: Biochemistry
Developmental Biology

description: The studies presented in this thesis gains a better understanding of the molecular mechanisms behind steroid treatment of premature babies by characterising and comparing the different gene expressed in isolated lung cells treated with synthetic or normal steroids. Our findings suggest that synthetic steroids induce a stronger gene response for a large number of genes when compared to natural steroids. This unique gene signature is one that favours upregulated genes over repressed genes suggesting that steroid induced fetal lung development is more dependent on induced genes. This will ultimately lead to the development of new treatment approaches for premature babies
Globular Cluster Systems of Early-type Galaxies in Low-density Environments
Creators: name: Cho, J.
name: Sharples, R. M.
name: Blakeslee, J. P.
name: Zepf, S. E.
name: Kundu, A.
name: Kim, H. -S.
name: Yoon, S. -J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Deep images of 10 early-type galaxies in low-density environments have been obtained with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. The global properties of the globular cluster (GC) systems of the galaxies have been derived in order to investigate the role of the environment in galaxy formation and evolution. Using the ACS Virgo Cluster Survey (ACSVCS) as a high-density counterpart, the similarities and differences between the GC properties in high- and low-density environments are presented. We find a strong correlation of the GC mean colours and the degree of colour bimodality with the host galaxy luminosity in low-density environments, in good agreement with high-density environments. In contrast, the GC mean colours at a given host luminosity are somewhat bluer (Δ(g-z) ~ 0.05) than those for cluster galaxies, indicating more metal-poor (Δ[Fe/H] ~ 0.10-0.15) and/or younger (Δage > 2 Gyr) GC systems than those in dense environments. Furthermore, with decreasing host luminosity, the colour bimodality disappears faster, when compared to galaxies in cluster environments. Our results suggest that: (1) in both high- and low-density environments, the mass of the host galaxy has the dominant effect on GC system properties, (2) the local environment has only a secondary effect on the history of GC system formation, (3) GC formation must be governed by common physical processes across a range of environments.
description: 22 pages, 17 figures, 6 tables, accepted for publication in MNRAS
UPDATING AND TESTING THE LEGEND OF COASTAL GEOMORPHOLOGICAL MAPPING:  SOME ITALIAN CASE-STUDIES
Creators: name: Brandolini, Pierluigi
name: Baldassarre, Maurizio Alessio
name: Bellotti, Piero
name: Bini, Monica
name: Bontempi, Sara
name: Chelli, Alessandro
name: Davoli, Lina
name: Donadio, Carlo
name: Ferrari, Marco
name: Mastronuzzi, Giuseppe
name: Marsico, Antonella
name: Mucerino, Luigi
name: Nesci, Olivia
name: Pennetta, Micla
name: Piacentini, Daniela
name: Raffi, Rossana
name: Sansò, Paolo
name: Tarragoni, Claudia
name: Valente, Alessio
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
Controlled stochastic networks in heavy traffic: Convergence of value functions
Creators: name: Budhiraja, Amarjit
name: Ghosh, Arka P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Scheduling control problems for a family of unitary networks under heavy traffic with general interarrival and service times, probabilistic routing and an infinite horizon discounted linear holding cost are studied. Diffusion control problems, that have been proposed as approximate models for the study of these critically loaded controlled stochastic networks, can be regarded as formal scaling limits of such stochastic systems. However, to date, a rigorous limit theory that justifies the use of such approximations for a general family of controlled networks has been lacking. It is shown that, under broad conditions, the value function of the suitably scaled network control problem converges to that of the associated diffusion control problem. This scaling limit result, in addition to giving a precise mathematical basis for the above approximation approach, suggests a general strategy for constructing near optimal controls for the physical stochastic networks by solving the associated diffusion control problem.
description: Published in at http://dx.doi.org/10.1214/11-AAP784 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
The Role of Microbiota and Dietary Metabolites on Gut Homeostasis
Creators: name: KEIRAN HUGH MCLEOD
Publisher: name: Monash University
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: This thesis examines how diets can change the makeup of the bacteria in our gut. These bacteria can then go on to produce products such as short chain fatty acids which can interact improve our body’s immune system. This improved immune function can help fight serious gut infections or prevent the development of type one diabetes. The protection from type one diabetes was also found to be able to pass from mother to child improving the outcomes for subsequent generations. This opens pathways for diet to be used as a treatment in many different conditions.
Classification Of Mixed Plant Samples By Next-Generation Sequencing
Creators: name: Ankenbrand, Markus
name: Grimmer, Gudrun
name: Härtel, Stephan
name: Steffan-Dewenter, Ingolf
name: Keller, Alexander
Publisher: name: Zenodo
Year: 2014
Subjects: ITS2
Pollen
Meta-barcoding
Classification

description: Classification of Mixed Plant Samples by Next-Generation Sequencing

Identification of species in mixed plant samples plays an important role in ecology and sheds light on problems from various research fields. Examples for such samples are pollens (also in bee collections and honey), algae in water samples, food or detritus. The advent of high throughput experiments rendered it possible to obtain sequence data for such samples as an alternative to manual, microscopic classification by experts. But tools for the automated classification of such samples originating from multiple plant species have not been established yet. We developed a bioinformatical workflow to analyze sequences of mixed plant samples through the highly variable species-specific internal transcribed spacer 2 (ITS2) region of the nuclear ribosomal DNA. ITS2 sequences are classified with the naive bayesian RDPclassifier specifically trained with reference sequences from the ITS2 database. To evaluate the performance, we compared results from classical identification based on light microscopy with our sequencing results for 16 bee collected pollen samples. The sequencing technique resulted in higher taxon richness (deeper assignments and more identified taxa) compared to light microscopy. Simulation analyses of taxon specificity and sensitivity indicate that 96% of taxa present in the database are correctly identifiable at the genus level and 70% at the species level. The pipeline thus presents a useful and efficient workflow to identify pollen at the genus and species level without requiring specialized expert knowledge and with high throughput.
description: Pictures of pollen and flower are in the public domain. The Illumina sequencer is courtesy of Illumina Inc. Graphics 2 and 3 are reused from Keller et al. (2015). Plant Biology 17: 558–566 (courtesy of Wiley). The 3D structure of ITS2 has been reconstructed by Alexander Keller (see: Keller et al. (2010) Biologia 65:388-391). The copyright holder of the honey image could not be found (please contact me if you have relevant information). Please be aware of these exceptions from the general CC-BY for the poster as a whole.
Cross-evaluating Epstein-Barr virus, human papilloma virus, human cytomegalovirus and human adenovirus in nasal polyps and turbinate mucosa
Creators: name: Schindele, Alexandra
name: Holm, Anna
name: Kraft, Sofie
name: Nylander, Karin
name: Allard, Annika
name: Olofsson, Katarina
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease in which inflammatory responses to exogenic stressors, such as viral infections, has been recognised. The role of viruses in CRSwNP pathogenesis is unclear. We aimed to characterise Epstein-Barr virus (EBV), human papillomavirus (HPV), human cytomegalovirus (HCMV), and human adenovirus (HAdV) in nasal polyps and adjacent paired healthy turbinate mucosa. We used real-time PCR for EBV, HCMV, and HAdV DNA detection, combined PCR/microarrays for HPV detection and genotyping, in samples from 45 patients with CRSwNP. Additionally, we used EBER in situ hybridisation for EBV detection. EBV detection with EBER-ISH was significantly higher in polyps (36%) versus turbinate mucosa (12%). None of the viral comparisons with PCR between polyps and turbinate mucosa for EBV-, HCMV- or HAdV-DNA showed statistically significant differences. All samples were HPV negative. We report higher expression of EBV in nasal polyps (36%) than in adjacent healthy turbinate mucosa (12%), using a valid method; EBER-ISH in 45 patients with CRSwNP. EBV might be a possible stressor that can trigger polypoid inflammation.
APPLIED GEOMORPHOLOGICAL MAPPING ADDRESSED TO COASTAL ENVIRONMENT: EXPERIENCE AND VALIDATION IN LIGURIA (ITALY)
Creators: name: Brandolini, Pierluigi
name: Corradi, Nicola
name: Faccini, Francesco
name: Ferrari, Marco
name: Firpo, Marco
name: Mucerino, Luigi
name: Vacchi, Matteo
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
Global and local expansion of magnetic clouds in the inner heliosphere
Creators: name: Gulisano, Adriana Maria
name: Demoulin, Pascal
name: Dasso, Sergio
name: Ruiz, Maria Emilia
name: Marsh, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Observations of magnetic clouds (MCs) are consistent with the presence of flux ropes detected in the solar wind (SW) a few days after their expulsion from the Sun as coronal mass ejections (CMEs). Both the \textit{in situ} observations of plasma velocity profiles and the increase of their size with solar distance show that MCs are typically expanding structures. The aim of this work is to derive the expansion properties of MCs in the inner heliosphere from 0.3 to 1 AU.We analyze MCs observed by the two Helios spacecraft using \textit{in situ} magnetic field and velocity measurements. We split the sample in two subsets: those MCs with a velocity profile that is significantly perturbed from the expected linear profile and those that are not. From the slope of the \textit{in situ} measured bulk velocity along the Sun-Earth direction, we compute an expansion speed with respect to the cloud center for each of the analyzed MCs. We analyze how the expansion speed depends on the MC size, the translation velocity, and the heliocentric distance, finding that all MCs in the subset of non-perturbed MCs expand with almost the same non-dimensional expansion rate ($ζ$). We find departures from this general rule for $ζ$ only for perturbed MCs, and we interpret the departures as the consequence of a local and strong SW perturbation by SW fast streams, affecting the MC even inside its interior, in addition to the direct interaction region between the SW and the MC. We also compute the dependence of the mean total SW pressure on the solar distance and we confirm that the decrease of the total SW pressure with distance is the main origin of the observed MC expansion rate. We found that $ζ$ was $0.91\pm 0.23$ for non-perturbed MCs while $ζ$ was $0.48\pm 0.79$ for perturbed MCs, the larger spread in the last ones being due to the influence of the environment conditions on the expansion.
Identifying Sneutrino Dark Matter: Interplay between the LHC and Direct Search
Creators: name: Lee, Hye-Sung
name: Li, Yingchuan
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Under R-parity, the lightest supersymmetric particle (LSP) is stable and may serve as a good dark matter candidate. The R-parity can be naturally introduced with a gauge origin at TeV scale. We go over why a TeV scale B-L gauge extension of the minimal supersymmetric standard model (MSSM) is one of the most natural, if not demanded, low energy supersymmetric models. In the presence of a TeV scale Abelian gauge symmetry, the (predominantly) right-handed sneutrino LSP can be a good dark matter candidate. Its identification at the LHC is challenging because it does not carry any standard model charge. We show how we can use the correlation between the LHC experiments (dilepton resonance signals) and the direct dark matter search experiments (such as CDMS and XENON) to identify the right-handed sneutrino LSP dark matter in the B-L extended MSSM.
description: 5 pages, 3 figures
GEOMORPHOLOGY OF ALPE DI CISLES IN THE ODLE GROUP (DOLOMITES, ITALY)
Creators: name: Coratza, Paola
name: Ghinoi, Alessandro
name: Marchetti, Mauro
name: Soldati, Mauro
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
Host autophagic response to Burkholderia pseudomallei infection
Creators: name: ZIQING WENG
Publisher: name: Monash University
Year: 2018
Subjects: Biochemistry
Molecular Biology

description: The bacterium Burkholderia pseudomallei is the causative agent of the disease melioidosis, prevalent in tropical areas of Asia and Australia. It is classified as a category B bioterrorism agent and is known to avoid classical host cell immune defenses. This project used a mouse cell model of infection to investigate the molecular mechanism by which the bacterium avoids being eliminated from infected cells. The response of cells to infection was assessed by determining changes in mitochondrial shape, and in the expression of key genes and proteins involved in cellular defense against bacteria in mammalian cells.
MAP OF THE NATURAL AND CULTURAL HERITAGE IN THE COASTAL LANDSCAPE OF THE CARIGNANO WINE DISTRICT OF THE SULCIS REGION (SW SARDINIA)
Creators: name: Di Gregorio, Felice
name: Frongia, Paolo
name: Ledda, Ponziana
name: Piras, Giuseppe
name: Forresu, Remo
Publisher: name: Università di Cagliari
Year: 2015

description: _
description: Geomorphology for Society, Conference proceedings
Metabolome modification and underlying biomarker of noise-induced hearing loss Guinea pig cochlear fluid
Creators: name: Qi, Guowei
name: Tang, Jinge
name: Qin, Handai
name: Han, Runnan
name: Jiang, Qingqing
name: Yu, Ning
name: Yang, Shiming
name: Han, Dongyi
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Noise-induced hearing loss (NIHL) is a kind of acquired sensorineural hearing loss and has shown an increasing incidence in recent years. Hence, elucidating the exact pathophysiological mechanisms and proposing effective treatment and prevention methods become the top priority. Though a great number of researches have been carried out on NIHL, few of them were focused on metabolites. To reveal the metabolomic changes in cochlear fluid after noise injury and search for underlying inner ear biomarkers of NIHL. In this study, cochlea fluid extracted from guinea pigs after impulse noise exposure were subjected to GC-MS and LC-MS untargeted metabolomics analysis. After impulse noise exposure, 62 significantly changed metabolites in guinea pig cochlea fluid were screened out and deoxyribose 1-phosphate was selected as the key metabolite and underlying biomarker for NIHL. KEGG pathway analysis showed that oxidative phosphorylation, glycerophospholipid metabolism, pyrimidine metabolism and pentose phosphate pathway were significantly changed at all observed time points after noise. This study effectively promoted the application of metabolomics in hearing research. The pathophysiology process of NIHL in the inner ear was closely connected with oxidative phosphorylation, glycerophospholipid metabolism, pyrimidine metabolism and pentose phosphate pathway and deoxyribose 1-phosphate could be the biomarker for NIHL.