cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lettre de Johann Jacob Ferber à Jean-François Séguier, 1774-07-22
Creators: name: Ferber, Johann Jacob
name: Ferber, Johann Jacob
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Botanique
Librairie

description: [transcription] A Carlscrone en Suède ce 22 juillet 1774.

Monsieur,

Il n'y a que quinze jours que j'ai eu l'honneur de recevoir votre lettre du 28 septembre 1773 avec un paquet des plantes séchées qui m'ont été très agréables. Je vous en fais mille remerciements et je compte de vous pouvoir envoyer les plantes d'Autriche que vous désirez et que Mr de Mygind a bien promis de procurer. Je lui ferai s'en souvenir, ce qui ne manquera pas à part qu'il sera très charmé de recevoir le Rhamnus infectorinus, dont il vous devient redevable. Si je saurais quelles plantes de Suède &c vous manquent, je pourrais bien [fol. 6 v] les avoir doubles et je vous les enverrai. Ayez la bonté de m'en informer. J'écris aujourd'hui à Stockholm d'envoyer avec le premier bâtiment qui partira pour Sète ou Marseille, la Mantissa alterna de Linné pour vous, Monsieur, à l'adresse de mon frère. Il vous en donnera des nouvelles à son temps. Le malheur est que la navigation, surtout de notre port de Carlscrone, est à l'agonie jointement avec le commerce. Autrefois, c`était tout autre chose. On ne sait pas trop d'où cela vient. Les financiers du [fol. 7 r] pays et ses habitants en sont probablement la cause. L'hiver passé, j'étais à Stockholm. Mr de Linné y était aussi et je voyais ce vieillard respectable tous les jours. J'avais même le plaisir de souper avec lui presque tous les soirs ; Nous avons parlé de vous, Monsieur, très souvent. Je lui faisais vos compliments et il me pria de vous assurer de son estime et de son amitié. Il y a tant des animaux et des plantes nouvelles de conservés qu'il est obligé de donner encore une nouvelle (la 13e) édition de son Système, mais je me doute très fort qu'elle ne sera pas imprimée en Suède mais à Londres. Je le saurai et je vous en avertirai. On m'a écrit que mes lettres sur l'Italie sont traduites à Strasbourg. S'il est ainsi, vous les verrez avant que je pourrai vous envoyer l'original allemand, ce que je ferai avec plaisir sans cela. Ordonnez-moi, Monsieur. Je suis avec beaucoup de respect toute ma vie, Monsieur,

Votre très humble et très obéissant serviteur,

Jean Jacques Ferber
description: [personnes citées] Franz von Mygind
description: [reférence bibliographique citée] Linné, Carl von, Mantissa plantarum alterna Generum editionis Vi et Specierum editionis II…, Holmiae, L. Salvii, 1771.
description: Source: [lieu de Conservation] Nîmes, Bibliothèque Carré d'Art [cote]ms. 94_1, fol. 7-8
description: Source: ark:/12148/btv1b100150711
Genotypic and Phenotypic Evaluation of Off-Type Grasses in Hybrid Bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] Putting Greens using Genotyping-by-Sequencing and Morphological Characterization
Creators: name: Reasor, Eric
name: Brosnan, Jim
name: Staton, Margaret
name: Lane, Thomas
name: Trigiano, Robert
name: Wadl, Phillip
name: Conner, Joann
name: Schwartz, Brian
Publisher: name: figshare
Year: 2017
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: 60702 Plant Cell and Molecular Biology
subject: Genetics
subject: 70305 Crop and Pasture Improvement (Selection and Breeding)
subject: FOS: Agriculture, forestry and fisheries
subject: 70302 Agronomy
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Many bermudagrass cultivars established for putting greens can be genetically unstable and lead to the occurrence of undesirable off-type grasses that vary in phenotype. The objective of this research was to genetically and phenotypically differentiate off-type grasses and hybrid cultivars.
ПОВЫШЕНИЕ КОНКУРЕНТОСПОСОБНОСТИ РЕГИОНАЛЬНЫХ БАНКОВ В СОВРЕМЕННЫХ УСЛОВИЯХ
Creators: name: ВАСИЛЬЕВА Н.К.
name: ВОРОНИН В.С.
name: УВАРОВА Д.Я.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: БАНКОВСКАЯ СИСТЕМА
РЕГИОНАЛЬНЫЕ БАНКИ
КОНКУРЕНЦИЯ
КОНКУРЕНТНЫЕ ПРЕИМУЩЕСТВА
КРЕДИТНЫЙ ПОРТФЕЛЬ
ДЕПОЗИТЫ
АКТИВЫ
БАНКОВСКИЕ УСЛУГИ
КРАСНОДАРСКИЙ КРАЙ
BANKING SYSTEM
REGIONAL BANKS
COMPETITION
COMPETITIVE ADVANTAGES
LOAN PORTFOLIO
DEPOSITS
ASSETS
BANKING SERVICES
KRASNODAR TERRITORY

description: Основными факторами, определяющими конкурентоспособность и уровень надежности банка, являются финансовая устойчивость, ликвидность и эффективная стратегия развития. Банки различного уровня большое внимание уделяют развитию данных направлений свой деятельности, особенно это важно в период экономической нестабильности реального сектора экономики страны, возрастания кредитного риска и снижения капитализации банков. С этой целью в научной работе рассмотрены основные конкурентные преимущества региональных банков ПАО «Крайинвестбанк», КБ «Кубань Кредит» ООО и ПАО КБ «Центр-инвест» в современных условиях, проведен анализ результатов их деятельности за период 2014 2018 гг., выявлены направления повышения конкурентоспособности: создание и ведение Центральным банком реестра успешных кредитных организаций, внесение отдельных норм регулирования функционирования на региональном рынке банковских услуг. В ходе исследования был установлен наиболее устойчивый и конкурентоспособный региональный банк из числа рассматриваемых.
High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii
Creators: name: Plaza, Julio
name: Casuso, Rafael
Publisher: name: figshare
Year: 2017
Subjects: Molecular Biology

description: Nine male swimmers enrolled in swimming competitions for at least 8 years (y) and in swimming training for at least 13 y volunteered for the study. Their physical characteristics were as follows: age 23.0 y (range 19-26 y), weight 78.5 kg (range 63-92 kg), height 180 cm (range 174-187 cm), extended upper limb size 187 cm (range 180-197 cm), and a maximal swimming speed of 2.0 m/s (range 1.88-2.10 m/s) (Table 1). Maximal swimming speed was recorded several times before (∼1 wk) the initiation of the study, and an experienced swimming coach, independent of the study, recorded the time required for the 25 m sprint, pushing off from the wall in the swimming pool. All subjects were fully informed of the risks and discomfort associated with the study, and all signed written consent. The study was conducted in accordance with the guidelines contained in the Declaration of Helsinki II and was approved by the local ethics committee of the University of Granada, Spain (protocol: 23/CEIH72015).
ОСОБЕННОСТИ УПРАВЛЕНИЯ ФИНАНСОВЫМИ РИСКАМИ ОРГАНИЗАЦИИ
Creators: name: ГУРФОВА С.А.
name: ЭЛЬГАЙТАРОВА Н.Т.
name: ЯЛМАЕВ Р.А.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ПРЕДПРИНИМАТЕЛЬСКИЙ РИСК
АНАЛИЗ
ФАКТОРЫ
ФИНАНСОВО-ХОЗЯЙСТВЕННАЯ ДЕЯТЕЛЬНОСТЬ
КОНТРОЛЬ
ФИНАНСОВЫЙ РИСК
ФИНАНСОВЫЙ РЕЗУЛЬТАТ
ENTREPRENEURIAL RISK
ANALYSIS
FACTORS
FINANCIAL AND ECONOMIC ACTIVITY
CONTROL
FINANCIAL RISK
FINANCIAL RESULT

description: Целью каждого коммерческого предприятия является получение максимально возможных результатов его деятельности. В то же время, учитывая высокую конкуренцию, желательно, чтобы все это было сделано с минимальными затратами. Чтобы реализовать эти желания, необходимо измерить вложенные средства с результатами их деятельности. В то же время любая хозяйственная деятельность, приносящая доход, сопровождается соответствующим риском. Риском можно управлять путем разработки различных мер, которые либо уменьшат негативные последствия риска, либо избавятся от него.
Wild Life: The lived experience of artistic creativity
Creators: name: ANGELA MARY CLARKE
Publisher: name: Monash University
Year: 2017
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 190404 Drama, Theatre and Performance Studies
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This project is a Performance Research investigation that explores how binary concepts such as mind/body, subject/object, and conscious/unconscious limit our capacity to gain a more appropriate and precise understanding of human artistic creativity. The project lays out an alternative philosophical background to examine and interpret artists’ experiences of creativity, and then turns to performance practice to apply, experiment, distil, perform, and articulate how the dynamic and generative processes of life are implicated in processes of artistic creativity. My central thesis is that artistic practitioners can consciously access experience differently, through corporeal practices, to activate fundamental structures for artistic purposes.
Control and Design of Multiscale Systems
Creators: name: Leyffer, Sven
name: Woodward, Carol
name: Reynolds, Dan
name: Tartakovski, Dan
Publisher: name: figshare
Year: 2017
Subjects: subject: 10301 Numerical Analysis
subject: FOS: Mathematics
subject: 10303 Optimisation
subject: 10110 Partial Differential Equations

description:
Whitepaper submitted to the 2017 DOE ASCR Applied Math Meeting
ИНВЕСТИЦИОННАЯ ПРИВЛЕКАТЕЛЬНОСТЬ ПРЕДПРИЯТИЯ
Creators: name: ОЗОВА И.М.
name: ГАЗИЕВА Л.Р.
name: КАТЧИЕВА З.Р.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ФИНАНСОВАЯ УСТОЙЧИВОСТЬ
ИНВЕСТИЦИОННАЯ ПРИВЛЕКАТЕЛЬНОСТЬ
ФАКТОРЫ
УПРАВЛЕНИЕ
ОЦЕНКА
ВЛОЖЕНИЯ
ФИНАНСОВАЯ ОТДАЧА
ФИНАНСОВЫЕ РЕСУРСЫ
ИНВЕСТИЦИОННЫЙ ПОТЕНЦИАЛ
СТАБИЛЬНОСТЬ
ПРИБЫЛЬНОСТЬ
КАЧЕСТВО ПРИБЫЛИ
ПОТЕНЦИАЛ ОРГАНИЗАЦИЙ
FINANCIAL STABILITY
INVESTMENT ATTRACTIVENESS
FACTORS
MANAGEMENT
EVALUATION
INVESTMENTS
FINANCIAL RETURN
FINANCIAL RESOURCES
INVESTMENT POTENTIAL
STABILITY
PROFITABILITY
QUALITY OF PROFIT
POTENTIAL OF ORGANIZATIONS

description: Статья посвящена определению зависимости инвестиционной привлекательности компании от показателей финансовой устойчивости. В качестве инструмента управления рассматривается оценка инвестиционного класса, основанная на финансовых показателях. Одной из главных задач производственного предприятия наряду с максимизацией прибыли, оптимизацией структуры капитала и обеспечением его финансовой устойчивости является обеспечение инвестиционной привлекательности. Эффективность управленческих решений, принятых с целью реализации вышеуказанных задач, обусловлена многими факторами, в первую очередь качественным анализом.
Additional file 2 of Identification of an immune-related signature indicating the dedifferentiation of thyroid cells
Creators: name: Wang, Xuemin
name: Peng, Wen
name: Li, Chunyan
name: Qin, Rujia
name: Zhong, Zhaoming
name: Sun, Chuanzheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Figure S2. GSEA identified differentiation-associated immune signalling pathways.
FITART – FEMALE BODY
Creators: name: Hunziker, Esther
name: Bachzetsis, Alexandra
name: Bruckner, Johanna
name: Essyad, Giulia
name: Gampert, Juliette
name: Gross, Maëlle
name: Guta, Maria
name: Niedermeier, Katrin
name: Vittucci, Teresa
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2021
Subjects: App
In-app show
Female Body
Fitness Art Club

description: FitArt provides art shows on your phone in the form of a fitness plan. The application is designed as a series of workouts, featuring exercises created by artists. Addressing the female connoted body, the second workout and in-app show Female Body approaches issues and structures of power in reference to sexuality, identity, gender and representation. It seeks to reflect on the experiences of women in their embodiments – as situated and congruent with places and times – according to the progress of society and technologies. Female Body collects newly produced video works by fourteen artists and artist duos, each active in the multifaceted Swiss art scene: !Mediengruppe Bitnik, Alexandra Bachzetsis, Johanna Bruckner, Giulia Essyad, Juliette Gampert, Maëlle Gross, Maria Guta, Esther Hunziker, Douna Lim & Théo Pesso, Katrin Niedermeier, Simone C. Niquille / Technoflesh, Colette Sadler & Mikko Gaestel, Ramaya Tegegne & Soraya Lutangu and Teresa Vittucci.
White_paper_Huan_Lei_DOE_PI.pdf
Creators: name: Lei, Huan
name: Stinis, Panos
name: Tartakovsky, Alexandre
name: Baker, Nathan
name: Xiantao Li
Publisher: name: figshare
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description:
Whitepaper submitted to the 2017 DOE ASCR Applied Math Meeting
АНАЛИЗ ФАКТОРОВ ИНВЕСТИЦИОННОГО РАЗВИТИЯ РЕГИОНА
Creators: name: РАДЧЕНКО М.В.
name: РАШИДОВА В.Р.
name: ТИМОШЕНКО Н.В.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: КРАСНОДАРСКИЙ КРАЙ
ИНВЕСТИЦИОННАЯ ПРИВЛЕКАТЕЛЬНОСТЬ
ИНВЕСТИЦИИ
СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЕ РАЗВИТИЕ
ИНВЕСТИЦИОННЫЙ ПОТЕНЦИАЛ
KRASNODAR TERRITORY
INVESTMENT ATTRACTIVENESS
INVESTMENTS
INVESTMENT POTENTIAL
SOCIAL AND ECONOMIC DEVELOPMENT

description: Проблема инвестирования в рыночной экономике была и остается наиболее актуальной, так как инвестиции являются одним из основных источников финансирования развития экономики. В настоящее время на регионы возложены полномочия по решению задач повышения показателей экономического развития, в связи, с чем возрастает значимость его инвестиционной деятельности. Региону необходимо привлекать инвестиции, чтобы реализовывать имеющиеся и развивать новые инвестиционные проекты и добиваться экономического подъема. В работе приведен анализ основных факторов, оказывающих влияние на инвестиционную привлекательность региона: экономических, финансовых, производственных, инфраструктурных, инновационных, трудовых, социальных, природно-климатических и географических. На основе факторного анализа выявлены проблемы, которые негативно влияют на инвестиционную привлекательность края, а также сформулированы предложения, позволяющие положительно повлиять на уровень инвестиционного развития региона.
title: ADCO, Cart. 186 (11 H 71), f. 0060r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0060r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Two-step crosslinked liquid-crystalline elastomer with reversible two-way shape memory characteristics
Creators: name: Yuchang Wang
name: Xuezhen Huang
name: Jianqi Zhang
name: Bi, Meng
name: Jindi Zhang
name: Hongyan Niu
name: Chensha Li
name: Haifeng Yu
name: Binsong Wang
name: Hongrui Jiang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Liquid-crystalline elastomers (LCEs) possess large and equilibrium reversible anisotropic dimensional change in response to applied stimuli. The deformation behavior demonstrated by current LCE materials under the stimuli are generally determined by their own geometries and the alignment distributions of liquid crystal (LC) units in the LCE matrices. Here we report a LCE whose synthesis was through a two-stage crosslinking coupled with a mechanical reshaping process, where the shape was mechanically reset before the final crosslinking. It demonstrated reversible memory and change between the initial geometries formed during the first crosslinking stage and any reshaped geometries under the stimuli. Its deformation is not influenced by the geometries and the alignment distributions of LC units in the LCE matrix. This characteristic in LCEs holds promise in a wide range of application researches requiring sophisticated functions and smart structures.
Experimental and theoretical spectroscopic and structural analyses of a new chalcone single crystal derived from 4-bromo-2-thiophenecarboxaldehyde
Creators: name: Zainuri, Dian Alwani
name: Suhana Arshad
name: Nuridayanti Che Khalib
name: Razak, Ibrahim Abdul
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Computational Biology

description: A new chalcone compound, (E)-1-([1,1′-Biphenyl]-4-yl)-3-(4-bromothiophen-2-yl)prop-2-en-1-one (BBTP), crystallizes in the monoclinic space group P21/c and its structure has been characterized by Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and ultraviolet and visible (UV-Vis) absorption spectroscopy. The structural and spectroscopic analyses of the chalcone were calculated using DFT/B3LYP method. Molecular structure, crystal structure arrangement, and intermolecular hydrogen bond interactions were determined by single crystal X-ray diffraction method. In the crystal packing, intermolecular C‒H···O hydrogen bonds and C‒H···π interaction formed infinite two-dimensional sheets, thus strengthening the crystal structure. Hirshfeld surface analysis, HOMO-LUMO, and molecular electrostatic potential results are also reported.
Mit Innovation gegen Armut. Sozial innovative Projekte im Kontext der Armutsprävention und Armutsbekämpfung in Kantonen, Städten und Gemeinden
Creators: name: Dittmann, Jörg
name: Heinzmann, Stefan
name: Knöpfel, Laura
Publisher: name: Bundesamt für Sozialversicherungen (BSV)
Year: 2016
Subjects: Armut
Soziale Innovation

description: Der vorliegende Bericht fasst die Ergebnisse einer Studie zusammen, welche von der Fachhochschule Nordwestschweiz FHNW im Jahr 2015 durchgeführt wurde. Die Studie hat Projekte in unterschiedlichen Themenbereichen der Armutsprävention (frühe Förderung, berufliche Integration und Übergang von Schule in Ausbildung oder in Beruf) identifiziert und nach den folgenden Innovationskriterien untersucht: a) Neue Grundidee der Armutsbekämpfung b) Anwendung von neuartigen Ansätzen und Methoden; c) Konzentration auf neue soziale Problemstellungen; d) Fokus auf bisher wenig beachtete Zielgruppen e) besonders wirkungsvolle und auf andere Kontexte übertragbare Modelle. Die Studie gibt einen interessanten Überblick über die Projektlandschaft im Bereich der Armutsprävention und -bekämpfung in der Schweiz.
Additional file 3 of Identification of an immune-related signature indicating the dedifferentiation of thyroid cells
Creators: name: Wang, Xuemin
name: Peng, Wen
name: Li, Chunyan
name: Qin, Rujia
name: Zhong, Zhaoming
name: Sun, Chuanzheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Table S1. Univariate analysis of prognosis-associated risk factors for low-differentiated PTCs in TCGA database.
ОСОБЕННОСТИ НАЛОГООБЛОЖЕНИЯ ПРИБЫЛИ ОРГАНИЗАЦИЙ ОТРАСЛИ ЭЛЕКТРОЭНЕРГЕТИКИ
Creators: name: ТЮПАКОВА Н.Н.
name: ГЛУЩЕНКО Е.А.
name: ТРЕГУБА К.В.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ДОХОДЫ
РАСХОДЫ
ПРИБЫЛЬ
НАЛОГООБЛОЖЕНИЕ
ПОСТОЯННЫЕ РАЗНИЦЫ
ВРЕМЕННЫЕ НАЛОГООБЛАГАЕМЫЕ РАЗНИЦЫ
НАЛОГОВОЕ БРЕМЯ
INCOME
EXPENSES
PROFIT
TAXATION
PERMANENT DIFFERENCES
TEMPORARY TAXABLE DIFFERENCES
TAX BURDEN

description: Налог на прибыль организаций имеет достаточно долгую историю развития. В разные времена и в разных странах этот налог приобретал те или иные черты, обусловленные специфическими экономическими условиями его применения. Российская практика налогообложения прибыли имеет свои особенности, определяемые порядком формирования налоговой базы. В статье представлены отличительные особенности формирования обязательств по налогу на прибыль у компаний отрасли электроэнергетики, связанные со значительными расхождениями формирования налогооблагаемой базы (прибыли) по данным налогового и бухгалтерского учетов. Проведена структурно-динамическая оценка налоговых платежей организаций отрасли электроэнергетики по признаку подразделения налогов в соответствии с источниками их оплаты, что позволило рассчитать показали фискального и реального налогового бремени и оценить степень переложения налоговых обязательств на организацию, потребителей и работников.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0897
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0897, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0897, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1 of Suicidal behaviours among Ugandan university students: a cross-sectional study
Creators: name: Kaggwa, Mark Mohan
name: Arinaitwe, Innocent
name: Muwanguzi, Moses
name: Nduhuura, Elicana
name: Kajjimu, Jonathan
name: Kule, Moses
name: Najjuka, Sarah Maria
name: Nkola, Rahel
name: Ajuna, Noble
name: Wamala, Nicholas Kisaakye
name: Machacha, Ivan
name: Mamun, Mohammed A.
name: Ho, Cyrus Su-Hui
name: Griffiths, Mark D.
name: Rukundo, Godfrey Zari
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
On the Impact of Numerical Analysis
Creators: name: Webster, Clayton
name: Hauck, Cory
Publisher: name: figshare
Year: 2017
Subjects: subject: Computation Theory and Mathematics
subject: FOS: Computer and information sciences

description: Whitepaper submitted to the 2017 DOE ASCR Applied Math Meeting" as part of the whitepaper metadata in Figshare.
 The growing complexity of physical models and high performance computing architectures necessitates a resurgence in basic mathematics research in order to provide a solid foundation for future simulation capa- bilities. At the same time, increasing complexity also demands a specialization and compartmentalization of roles in the scientific computing work flow that, while also necessary, poses significant risk to mathematical research and its ability to have meaningful impact on DOE applications. Strategies should be developed to help mitigate this risk by ensuring the transfer of mathematical technologies to application domains, and to facilitate meaningful feedback from computational scientists and application specialists.
Exploring midwifery students' views and experiences of caseload midwifery: A cross-sectional survey conducted in Victoria, Australia
Creators: name: Dawson, Kate
name: Newton, Michelle
name: Forster, Della
name: McLachlan, Helen
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4204
subject: Midwifery
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: No description supplied.
Synthesis and crystal structure of 2,9-bis(2-fluorobenzyl)-β-carbolin-2-ium bromide
Creators: name: Mazlin Mohideen
name: Kamaruzaman, Nur Azzalia
name: Ramu Meesala
name: Mohd Mustaqim Rosli
name: Mohd Nizam Mordi
name: Mansor, Sharif Mahsufi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: A new compound of 2,9-bis(2-fluorobenzyl)-β-carbolinium bromide, C25H19BrF2N2 has been synthesized by the decarboxylation of ethyl β-carboline-3-carboxylate with 2-fluorobenzyl bromide in the presence of sodium hydride in DMF, with good yield (92%). Its structure was characterized by 1H and 13C NMR, FT-IR, MS (ESI-MS) spectrum and elemental analysis. Meanwhile, its crystal structure was determined by X-ray single-crystal diffraction. The crystal is of orthorhombic, space group P212121 with a = 7.4788(13), b = 15.548(3), c = 17.386(3) Å, V = 2021.7(6) Å3, Z = 4, F(000) = 944, Dc = 1.529 g/cm3, µ = 2.066 mm−1 and α = 90°, β = 90°, γ = 90°. It has potential as an anticancer agent.
МЕТОДЫ НАЧИСЛЕНИЯ АМОРТИЗАЦИИ КАК РЕЗЕРВ УЛУЧШЕНИЯ ФИНАНСОВЫХ РЕСУРСОВ
Creators: name: АБДОКОВА Л.З.
name: АБДУЕВ М.Х.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: АМОРТИЗАЦИЯ
АМОРТИЗАЦИОННАЯ ПОЛИТИКА
УСКОРЕННАЯ АМОРТИЗАЦИЯ
СПОСОБЫ НАЧИСЛЕНИЯ АМОРТИЗАЦИИ
МЕТОДЫ НАЧИСЛЕНИЯ АМОРТИЗАЦИИ
ОСНОВНЫЕ СРЕДСТВА
ПРИБЫЛЬ
DEPRECIATION
DEPRECIATION POLICY
ACCELERATED DEPRECIATION
DEPRECIATION METHODS
FIXED ASSETS
PROFIT

description: В статье изложены вопросы, связанные с формированием и применением в бухгалтерском и налоговом учете амортизационной политики, рассмотрены различные методы начисления амортизации основных средств и представлена их сравнительная характеристика, определены приоритетные направления совершенствования амортизационной политики
Public Management in Switzerland: Challenges and Solutions
Creators: name: Meyer, Matthias
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2014
Subjects: subject: Switzerland
subject: political system
subject: public administration
subject: challenges
subject: solutions
subject: 320 - Politik
subject: 330 - Wirtschaft
subject: 350 - Öffentliche Verwaltung

description: When describing a public administration it is first necessary to describe the political system of the country the administration is in. Therefore this presentation starts with the political system of Switzerland and takes than the challenges and possible solutions for the Swiss administration.
Additional file 1 of Internalizing symptoms in adolescence are modestly affected by symptoms of anxiety, depression, and neurodevelopmental disorders in childhood
Creators: name: Doering, Sabrina
name: Larsson, Henrik
name: Halldner, Linda
name: Gillberg, Christopher
name: Kuja-Halkola, Ralf
name: Lundström, Sebastian
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
ЭФФЕКТИВНОЕ УПРАВЛЕНИЕ ДЕНЕЖНЫМИ ПОТОКАМИ ЭКОНОМИЧЕСКОГО СУБЪЕКТА
Creators: name: АДАМЕНКО А.А.
name: ПЕТРОВ Д.В.
name: МАРКЕЛОВ В.В.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ДЕНЕЖНЫЕ СРЕДСТВА
ДЕНЕЖНЫЕ ПОТОКИ
УПРАВЛЕНИЕ
ЭФФЕКТИВНОСТЬ
CASH
CASH FLOWS
MANAGEMENT
EFFICIENCY

description: Денежные средства экономического субъекта представляют собой ограниченный ресурс, который участвует при реализации всех без исключения управленческих решений, и это придает особую значимость их эффективному управлению. Цель управления денежными потоками экономического субъекта состоит в создании и обеспечении оптимального остатка данных активов на счетах в банках, полученного в результате оптимизации их притоков и оттоков. Различают денежные потоки от текущих операций, от инвестиционных операций и от финансовых операций. Управление денежными потоками строится на концепции их неизменной оборачиваемости. При эффективно построенном денежном потоке у организации отсутствует необходимость использовать заемный капитал. От эффективности денежных потоков также зависит платежеспособность экономического субъекта, так несбалансированность денежного потока влечет за собой риск неплатежеспособности.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0344
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0344, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0344, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
ОСОБЕННОСТИ ВЕДЕНИЯ БУХГАЛТЕРСКОГО УЧЕТА ОСНОВНЫХ СРЕДСТВ И ИХ АМОРТИЗАЦИИ В СЕЛЬСКОХОЗЯЙСТВЕННЫХ ОРГАНИЗАЦИЯХ
Creators: name: АДАМЕНКО А.А.
name: ХОРОЛЬСКАЯ Т.Е.
name: ЛИТОВКА Ю.С.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ОСНОВНЫЕ СРЕДСТВА
АМОРТИЗАЦИЯ
УЧЕТ
ПЕРВИЧНАЯ УЧЕТНАЯ ДОКУМЕНТАЦИЯ
FIXED ASSETS
DEPRECIATION
ACCOUNTING
PRIMARY ACCOUNTING DOCUMENTATION

description: В современных условиях развитие сельскохозяйственной организации во многом зависит от комплектности обеспечения и эффективности использования основных средств. В связи с этим особенности ведения бухгалтерского учета данных активов оказывает непосредственное влияние на производство, размер затрат, и как следствие, на размер налоговой нагрузки экономического субъекта. Все факты хозяйственной жизни по учету основных средств в сельскохозяйственных организациях оформляются соответствующими формами первичных документов. На каждую классификационную группу основных средств (здания, сооружения, передаточные устройства) заводят отдельные описи инвентарных карточек. Синтетический учет наличия и движения основных средств ведется на предназначенных для этого счетах бухгалтерского учета, основными из которых являются счет 01 «Основные средства» и счет 02 «Амортизация основных средств».
Advancing Beyond Interpretive Simulation to Inference for Prediction
Creators: name: Wildey, Tim
name: Butler, Troy
name: Jakeman, John
Publisher: name: figshare
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: Multiscale, multiphysics, multifidelity modeling research
Whitepaper submitted to the 2017 DOE ASCR Applied Math Meeting
Tripurarahasya with Sthaneshwar Timalsina
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2021
Subjects: sarvamnaya-oral-tradition-archive
sarvamnaya
vimarsha-foundation

description: Vimarsha Foundation will soon be offering a course on Tripurarahasya. We invite all the enthusiasts to register at https://docs.google.com/forms/d/1Cd_qwsqCh7H3TRcWElyq-4AAYSain-cRJmupshUbO8E/edit

Original YouTube video: https://www.youtube.com/watch?v=ErfA6PLQmOc

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
МЕЖДУНАРОДНАЯ ПРАКТИКА СОСТАВЛЕНИЯ ОТЧЕТА О ДВИЖЕНИИ ДЕНЕЖНЫХ СРЕДСТВ
Creators: name: АДЖИЕВА А.И.
name: БАЙРАМУКОВА Ф.У-А.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: ДЕНЕЖНЫЕ СРЕДСТВА
АНАЛИЗ
ЧИСТАЯ ПРИБЫЛЬ
БУХГАЛТЕРСКИЙ БАЛАНС
ФИНАНСОВАЯ ОТЧЁТНОСТЬ
CASH ASSETS
ANALYSES
NET PROFIT
BALANCE SHEET
FINANCIAL STATEMENTS

description: Данная статья посвящена составлению отчета о движении денежных средств в международной практике. Актуальность темы исследования научной работы заключается в том, что в современных условиях хозяйствования денежные потоки играют ключевую роль в управлении фирмой. Денежные потоки циркулируют по всем бизнес процессам внутри организации, непрерывно снабжая ее подразделения необходимыми ресурсами. В настоящее время недостаточно разработана целостная система методического обеспечения анализа денежных потоков, базирующаяся на взаимосвязи его методологии с процессами управления и прогнозирования. В современной научной литературе работ, посвященных исследованию потоков денежных средств в различных странах, довольно мало. Статья посвящена рассмотрению стандарта финансовой отчетности в соответствии со стандартом МСФО (IAS) 7. А также приведен анализ необходимости отчета о движении денежных средств.
Exploring Reasons for the Resistance to Sustainable Management within Non-Profit Organizations
Creators: name: Daub, Claus-Heinrich
name: Scherrer, Yvonne Myrtha
name: Verkuil, Arie Hans
Publisher: name: MDPI
Year: 2014
Subjects: subject: Keywords: corporate responsibility
subject: corporate sustainability
subject: sustainable management
subject: non-profit organizations
subject: non-profit management
subject: 360 - Soziale Probleme, Sozialdienste, Versicherungen
subject: 650 - Management

description: The numerous empirical and conceptual studies that have been conducted over recent years concerning the social responsibility of enterprises and their contributions towards sustainable development have given very little consideration to non-profit organizations (NPOs). This is surprising, because NPOs are confronted with very similar challenges to profit-orientated enterprises regarding their evolution into sustainable organizations. This paper is a preliminary conceptual study and explores the question of why the corporate social responsibility, or corporate sustainability, of NPOs has to date been both neglected by research establishments and also extensively ignored by the NPOs during their day-to-day practical management. The example of church and pastoral institutions in Germany is used to demonstrate the extent to which they take account of ecological and social aspects in their management systems and processes and, thus, implement sustainable management within their day-to-day practice. The paper concludes with some proposals for further empirical and conceptual research projects, which are designed to analyze developments within NPOs with relation to the integration of sustainability into their management systems and processes.
[Querido Julio Cortázar: Espero que estés bien, mejor dicho que estés mejor]
Creators: name: Lea, Lublin
name: Lublin, Lea
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Rafael San Martín
Cárcel
Testimonio

description: Destinatario: Cortázar, Julio
description: Source: Num.Ref. : JC-DY-CAR-02.029
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Additional file 1 of The German version of the Cultural Competence Assessment (CCA-G): cross-cultural adaptation and validation study in Austrian acute care settings
Creators: name: Osmancevic, Selvedina
name: Großschädl, Franziska
name: Stijic, Marko
name: Lohrmann, Christa
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Additional file 1. Translation and adaptation process.
Additional file 6: of Direct comparison of [11C] choline and [18F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients
Creators: name: Verburg, Niels
name: Koopman, Thomas
name: Yaqub, Maqsood
name: Hoekstra, Otto
name: Lammertsma, Adriaan
name: Schwarte, Lothar
name: Barkhof, Frederik
name: Pouwels, Petra
name: Heimans, Jan
name: Reijneveld, Jaap
name: Rozemuller, Annemieke
name: Vandertop, William
name: Wesseling, Pieter
name: Boellaard, Ronald
name: Witt Hamer, Philip
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: ROC curve of [11C] choline and [18F] FET in high- and low-grade gliomas. (PDF 66 kb)
ВИДЫ КАССОВЫХ АППАРАТОВ, А ТАКЖЕ НЕОБХОДИМОСТЬ ИСПОЛЬЗОВАНИЕ ИХ ИНТЕРНЕТ-МАГАЗИНАМИ
Creators: name: АДЖИЕВА А.И.
name: БОРЛАКОВА Т.М.
Publisher: name: Вестник Академии знаний
Year: 2019
Subjects: КАССОВЫЕ АППАРАТЫ
ФИСКАЛЬНЫЕ РЕГИСТРАТОРЫ
АВТОНОМНЫЕ
НЕАВТОНОМНЫЕ
ИНТЕРНЕТ-ТОРГОВЛЯ
CASH REGISTERS
FISCAL REGISTRARS
AUTONOMOUS
NONAUTONOMOUS
ONLINE COMMERCE

description: В данной статье авторы постарались объяснить разницу между разными типами кассовых аппаратов (хотя некоторые из них даже не являются кассовыми аппаратами, но предприниматели привыкли их так называть). Они выделяют, что сегодня на рынке представлено множество видов кассовых аппаратов, однако выбор того, который будет использован в бизнесе, остается за предпринимателем. Современные контрольнокассовые аппараты различают по области их применения и по конструктивным, технологическим особенностям. Обращают внимание на отдельные тонкости и особенности: например можно сказать, что все аппараты делятся на два вида автономные и неавтономные. Авторы рыскрывают технические характеристики и сферу их применения. Рассмотрено и обосновано использование кассового аппарата для интернет магазина.
Reproducibility in Software Engineering
Creators: name: Dellaiera, Pol
Publisher: name: Zenodo
Year: 2025
Subjects: reproducibility
software engineering

description: The concept of reproducibility has long been a cornerstone in scientific research, ensuring that results are robust, repeatable, and can be independently verified. This concept has been extended to computer science, focusing on the ability to recreate identical software artefacts. However, the importance of reproducibility in software engineering is often overlooked, leading to challenges in the validation, security, and reliability of software products.

This master's thesis aims to investigate the current state of reproducibility in software engineering, exploring both the barriers and potential solutions to making software more reproducible and raising awareness. It identifies key factors that impede reproducibility such as inconsistent environments, lack of standardisation, and incomplete documentation. To tackle these issues, I propose an empirical comparison of tools facilitating software reproducibility.

To provide a comprehensive assessment of reproducibility in software engineering, this study adopts a methodology that involves a hands-on evaluation of four different methods and tools. Through a systematic evaluation of these tools, this research seeks to determine their effectiveness in establishing and maintaining identical software environments and builds.

This study contributes to academic knowledge and offers practical insights that could influence future software development protocols and standards.
Édimbourg, National Library, Adv. MS 19.2.1, fol. 1r-6v, transcription normalisée (Gregorius Digital EN1-1)
Creators: name: Andersen, Peter
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025

description: Ce document PDF est une transcription normalisée du manuscrit Édimbourg, National Library, Adv. MS 19.2.1, fol. 1r-6v, complété par des transcriptions normalisées partielles des manuscrits Oxford, Bodleian Library, MS Eng. Poet. a. 1, fol. 45r-47r, et Londres, British Library, Cotton MS Cleopatra D.IX, fol. 153v-161v, contient le récit du Bon Pécheur et est édité dans le cadre du projet Gregorius Digital sous le sigle EN1-1 (dir. Peter Andersen – ARCHE UMR 3400 – Université de Strasbourg)
Reproducibility in Software Engineering
Creators: name: Dellaiera, Pol
Publisher: name: Zenodo
Year: 2024
Subjects: reproducibility
software engineering

description: The concept of reproducibility has long been a cornerstone in scientific research, ensuring that results are robust, repeatable, and can be independently verified. This concept has been extended to computer science, focusing on the ability to recreate identical software artefacts. However, the importance of reproducibility in software engineering is often overlooked, leading to challenges in the validation, security, and reliability of software products.

This master's thesis aims to investigate the current state of reproducibility in software engineering, exploring both the barriers and potential solutions to making software more reproducible and raising awareness. It identifies key factors that impede reproducibility such as inconsistent environments, lack of standardisation, and incomplete documentation. To tackle these issues, I propose an empirical comparison of tools facilitating software reproducibility.

To provide a comprehensive assessment of reproducibility in software engineering, this study adopts a methodology that involves a hands-on evaluation of four different methods and tools. Through a systematic evaluation of these tools, this research seeks to determine their effectiveness in establishing and maintaining identical software environments and builds.

This study contributes to academic knowledge and offers practical insights that could influence future software development protocols and standards.
FlexWork Survey 2016
Creators: name: Weichbrodt, Johann
name: Berset, Martial
name: Schläppi, Michael
Publisher: name: Hochschule für Angewandte Psychologie FHNW
Year: 2016
Subjects: subject: 150 - Psychologie

description: Mit zwei verschiedenen Datenerhebungen haben wir untersucht wie a) mobil die erwerbstätige Bevölkerung in der Schweiz arbeitet (Erwerbstätigenbefragung) und wie b) unterstützend die Strukturen für mobile und flexible Arbeit in den Unternehmen sind (Unternehmensbefragung). Diese Erhebung hat nach 2014 zum zweiten Mal stattgefunden, was auch Vergleiche über die Zeit zulässt.
Advancing Raman model calibration for perfusion bioprocesses using spiked harvest libraries
Creators: name: Kolar, Jakub
name: Herwig, Christoph
name: Bielser, Jean‐Marc
name: Romann, Patrick
name: Tobler, Daniela
name: Villiger, Thomas
Publisher: name: Wiley
Year: 2022
Subjects: subject: flowcell
subject: harvestlibrary
subject: model calibration
subject: MVDA
subject: Raman spectroscopy
subject: spiking
subject: 500 - Naturwissenschaften

description: Background Raman spectroscopy has gained popularity to monitor multiple process indicators simultaneously in biopharmaceutical processes. However, robust and specific model calibration remains a challenge due to insufficient analyte variability to train the models and high cross-correlation of various media components and artifacts throughout the process. Main Methods A systematic Raman calibration workflow for perfusion processes enabling highly specific and fast model calibration was developed. Harvest libraries consisting of frozen harvest samples from multiple CHO cell culture bioreactors collected at different process times were established. Model calibration was subsequently performed in an offline setup using a flow cell by spiking process harvest with glucose, raffinose, galactose, mannose, and fructose. Major Results In a screening phase, Raman spectroscopy was proven capable not only to distinguish sugars with similar chemical structures in perfusion harvest but also to quantify them independently in process-relevant concentrations. In a second phase, a robust and highly specific calibration model for simultaneous glucose (root mean square error prediction [RMSEP] = 0.32 g L−1) and raffinose (RMSEP = 0.17 g L−1) real-time monitoring was generated and verified in a third phase during a perfusion process. Implication The proposed novel offline calibration workflow allowed proper Raman peak decoupling, reduced calibration time from months down to days, and can be applied to other analytes of interest including lactate, ammonia, amino acids, or product titer. Graphical Abstract and Lay Summary Building accurate and robust Raman models for online monitoring of cell culture processes remains a difficult and time-consuming process, particularly for perfusion processes. In this study, the authors developed a novel offline calibration approach based on design-of-experiment spiking and a harvesting library. The Raman spectra of these spiked harvest samples allowed proper peak decoupling and model generation within days instead of weeks or even months. The approach has been successfully applied to monitor various sugars in perfusion bioreactors and other compounds as well as process modes may equally benefit from the described workflow.
Exposing Latent Hierarchies for Large-Scale Design and Discovery
Creators: name: Zichao Di
name: Leyffer, Sven
name: Otten, Matthew
name: Wild, Stefan
Publisher: name: figshare
Year: 2017
Subjects: subject: 10303 Optimisation
subject: FOS: Mathematics
subject: 10399 Numerical and Computational Mathematics not elsewhere classified
subject: 10599 Mathematical Physics not elsewhere classified

description: Whitepaper submitted to the 2017 DOE ASCR Applied Math Meeting addresses the advancing in numerical optimization for large-scale scientific discovery in complex physics.