cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lectures on quantization of gauge systems
Creators: name: Reshetikhin, N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A gauge system is a classical field theory where among the fields there are connections in a principal G-bundle over the space-time manifold and the classical action is either invariant or transforms appropriately with respect to the action of the gauge group. The lectures are focused on the path integral quantization of such systems. Here two main examples of gauge systems are Yang-Mills and Chern-Simons.
description: 63 pages, 22 figures. Based on lectures given at the Summer School "New paths towards quantum gravity", Holbaek, Denmark, 2008
Distinct Effects of Interleukin-1β Inhibition upon Cytokine Profile in Patients with Adult-Onset Still’s Disease and Active Articular Manifestation Responding to Canakinumab
Creators: name: Ghannam, Khetam
name: Zernicke, Jan
name: Kedor, Claudia
name: Listing, Joachim
name: Burmester, Gerd-R.
name: Foell, Dirk
name: Feist, Eugen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: adult-onset Still's disease
subject: canakinumab
subject: cytokines
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Adult-onset Still’s disease (AOSD) is a systemic auto-inflammatory disease characterized by the presence of immunologically mediated inflammation and deficient resolution of inflammation. Canakinumab is an approved IL-1β inhibitor in the treatment of AOSD with a balanced efficacy and safety profile. Since inflammatory cytokines play a major role in the pathogenesis of AOSD, we investigated the effects of canakinumab on the cytokine profile of AOSD patients from a randomized controlled trial. Multiplex analysis and ELISA were used to test the concentrations of several cytokines at three time points—week 0 (baseline), week 1 and week 4—in two patient groups—placebo and canakinumab. Two-way repeated-measures analysis of variance revealed a significant temporal effect on the concentrations of MRP 8/14, S100A12, IL-6 and IL-18 with a significant decrease at week 4 in the canakinumab group exclusively. Comparing responders with non-responders to canakinumab showed a significant decrease in MRP 8/14, IL-1RA, IL-18 and IL-6 in responders at week 4, while S100A12 levels decreased significantly in responders and non-responders. In summary, canakinumab showed a striking effect on the cytokine profile in patients with AOSD, exhibiting a clear association with clinical response.
Bouguer gravity field of the Tuscan Archipelago (central Italy)
Creators: name: Milano, M.
name: Pierri, I.
name: Florio, G.
name: Cella, F.
name: Fedi, M.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: In this paper, we present a new Bouguer gravity map of the Northern Tuscan offshore (central Italy), based on original gravity data acquired on the islands of the Tuscan Archipelago. Our dataset integrates 274 unpublished gravity field measurements with 126 available marine gravity data of the northern Tyrrhenian Sea. The Bouguer anomaly map shows a westward and southward increase of the regional gravity field associated with the uplift of the Moho boundary from central Apennines towards the Tyrrhenian Sea. At a local scale, several Bouguer anomalies are well associated with the igneous plutons of the Elba, Montecristo and Capraia islands, as a result of a deep density contrast between the granitoid intrusive rocks and the embedding metamorphic basement. The presented Bouguer anomaly map represents a useful tool for future studies of the complex geological and geodynamical setting of the Tuscan Archipelago and of the buried and deep igneous structures.
Promoting Integrated Care through a Global Treatment Budget
Creators: name: Afraz, Farideh Carolin
name: Vogel, Amyn
name: Dreher, Carsten
name: Berghöfer, Anne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: global treatment budget
subject: flexible
subject: integrated treatment models FIT
subject: cross-sectoral care
subject: Rogers’ innovation diffusion theory
subject: qualitative study
subject: qualitative content analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Since 2003, as a means of enabling integrated care the German mental health care system has offered the innovative option of agreeing a Global Treatment Budget (GTB, also known as a regional psychiatric budget or innovative flexible and integrative forms of treatment FIT) with health insurers and regional care providers across sectors. Despite promoting legal frameworks and positive evidence on improving quality of patient care, this model has not spread widely. The aim of this study is to identify inhibiting and facilitating factors for the innovation diffusion. Theory and methods: We conducted expert interviews with 19 actors from nine German regions involved in GTBs, using a self-developed questionnaire based on Rogers' theory on innovation diffusion extended by the innovation system approach. Interviews were analysed applying qualitative content analysis. Code categories were built deductively operationalising Rogers' theory and inductively from the data generated. Results: Observability of the innovation was perceived as good, but trialability, reversibility, compatibility with regular care structures as low, and thus the perceived risks of adoption as high. Complexity up to implementation is high, caused by numerous individuals and stakeholder groups involved. Diffusion took place in environments of strong individuals with venturesomeness, opinion leadership, and informal networking. As favourable framework conditions the monopoly and non-profit position of hospitals in well-defined care regions were identified. Discussion and conclusions: Diffusion of integrated care could be accelerated by dissolving the multi-actor constellation, changing the communication strategy, and adapting the legal framework.
Nonmonotonic inelastic tunneling spectra due to emission of surface magnons in itinerant electron ferromagnetic junctions
Creators: name: Tkachov, Grygoriy
Publisher: name: Universität Regensburg
Year: 2004
Subjects: subject: 530 Physik

description: We propose an itinerant electron theory of nonmonotonic inelastic tunneling spectra of ferromagnetic junctions observed in several recent experiments. Assuming that the Coulomb interaction between electrons across the barrier is poorely screened due to the exponential suppression of the band electron density inside the barrier, we consider a process where a hot electron from one ferromagnet during the tunneling excites a magnon at the surface of the other ferromagnet in the course of the exchange scattering with a Fermi sea electron from the opposite side. For this process one can derive an inelastic transfer Hamiltonian in which the matrix elements of the electron- magnon coupling depend on the magnon wave-vector (and hence on its energy) via the long-range Coulomb potential. This dependence can account for the sharp peaks observed in the low-temperature tunneling spectra of a number of ferromagnetic junctions at the excitation energies much smaller than the Curie temperature of the ferromagnets.
title: Epigallocatechin Gallate in Progressive MS
title: A Randomized, Placebo-Controlled Trial
titleType: Subtitle
Creators: name: Rust, Rebekka
name: Chien, Claudia
name: Scheel, Michael
name: Brandt, Alexander U.
name: Dörr, Jan
name: Wuerfel, Jens
name: Klumbies, Katharina
name: Zimmermann, Hanna
name: Lorenz, Mario
name: Wernecke, Klaus-Dieter
name: Bellmann-Strobl, Judith
name: Paul, Friedemann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Catechin
subject: Magnetic Resonance Imaging
subject: Disease Progression
subject: Double-Blind Method
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: To examine whether treatment with epigallocatechin gallate (EGCG) influences progression of brain atrophy, reduces clinical and further radiologic disease activity markers, and is safe in patients with progressive multiple sclerosis (PMS). Methods: We enrolled 61 patients with primary or secondary PMS in a randomized double-blind, parallel-group, phase II trial on oral EGCG (up to 1,200 mg daily) or placebo for 36 months with an optional open-label EGCG treatment extension (OE) of 12-month duration. The primary end point was the rate of brain atrophy, quantified as brain parenchymal fraction (BPF). The secondary end points were radiologic and clinical disease parameters and safety assessments. Results: In our cohort, 30 patients were randomized to EGCG treatment and 31 to placebo. Thirty-eight patients (19 from each group) completed the study. The primary endpoint was not met, as in 36 months the rate of decrease in BPF was 0.0092 +/- 0.0152 in the treatment group and -0.0078 +/- 0.0159 in placebo-treated patients. None of the secondary MRI and clinical end points revealed group differences. Adverse events of EGCG were mostly mild and occurred with a similar incidence in the placebo group. One patient in the EGCG group had to stop treatment due to elevated aminotransferases (>3.5 times above normal limit). Conclusions: In a phase II trial including patients with multiple sclerosis (MS) with progressive disease course, we were unable to demonstrate a treatment effect of EGCG on the primary and secondary radiologic and clinical disease parameters while confirming on overall beneficial safety profile. Clinicaltrial.gov Identifier NCT00799890. Classification of Evidence This phase II trial provides Class II evidence that for patients with PMS, EGCG was safe, well tolerated, and did not significantly reduce the rate of brain atrophy.
Two-Nucleon Bound States in Quenched Lattice QCD
Creators: name: Yamazaki, T.
name: Kuramashi, Y.
name: Ukawa, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We address the issue of bound state in the two-nucleon system in lattice QCD. Our study is made in the quenched approximation at the lattice spacing of a = 0.128 fm with a heavy quark mass corresponding to m_pi = 0.8 GeV. To distinguish a bound state from an attractive scattering state, we investigate the volume dependence of the energy difference between the ground state and the free two-nucleon state by changing the spatial extent of the lattice from 3.1 fm to 12.3 fm. A finite energy difference left in the infinite spatial volume limit leads us to the conclusion that the measured ground states for not only spin triplet but also singlet channels are bounded. Furthermore the existence of the bound state is confirmed by investigating the properties of the energy for the first excited state obtained by 2x2 diagonalization method. The scattering lengths for both channels are evaluated by applying the finite volume formula derived by Luscher to the energy of the first excited states.
description: 34 pages, 28 figures
Characterisation of the new Vps35 p.D620N KI mouse model of Parkinson's disease
Creators: name: Cataldi, Stefano
Publisher: name: University of British Columbia
Year: 2019

description: Vacuolar protein sorting 35 (VPS35) is a core component of the retromer trimer required for endosomal membrane-associated protein trafficking. The discovery of a missense mutation, Vps35 p.D620N, implicates retromer dysfunction in the pathogenesis of Parkinson’s disease (PD). Our group have generated and characterized a knock-in mouse with a Vps35 p.D620N substitution (herein referred to as VKI) from 3 to 18 months of age. Stereological counting of tyrosine hydroxylase (TH)-positive nigral neurons was comparable between mutant and wild-type animals. Quantification of extracellular dopamine by striatal microdialysis of freely moving animals, and high performance liquid chromatography, was comparable across genotypes at all ages. However, dopamine metabolites appear increased in young VKI mice, suggesting increase dopamine turnover. Assessment of nigrostriatal function by ex-vivo fast scan cyclic voltammetry (FSCV) revealed an increase in dopamine release in brain slices from 3-month-old VKI, and a reduction in older animals. Western blot analysis of VKI striata revealed increased in the vesicular monoamine transporter 2 (VMAT2), and decreased in dopamine transporter (DAT) levels, at 3 and 18 months of age. These results were supported by confocal imaging of the dorsolateral striatum, showing an increase in the size of VMAT2-positive synaptic structures, and a significant loss of DAT cluster density in VKI mice. Standardized behavioural testing failed to observe overt movement disorder. Cognitive evaluation showed altered exploratory behaviour and perseveration in both young and old VKI animals. These alterations in dopaminergic activity and behaviour are reminiscent of prodromal PD. Together these results implicate retromer in dopaminergic function and early PD stage symptoms and provide a molecular mechanism for dopamine dysregulation in VPS35 p.D620N parkinsonism.
Geohazards of Saudi Arabia
Creators: name: Hird, Robert
name: Di Matteo, Nicola
name: Gulerce, Umit
name: Babu, Vijai Lal Sunderlal
name: Rafiq, Atif
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Geohazards play an important role in land development and have serious impacts if not considered at early planning stages. Identification of potential geohazards, assessment of their likelihood and severity is a complex task that requires integration of various information through a multi-disciplinary approach. An introductory level assessment of potential geohazards in Saudi Arabia with compilation and interpretation of publicly available data using geographic information system tools is presented in this study. The outcome is a geohazard map presenting reported and predicted geohazards including tectonics and volcanism, rock subsidence, expansive and collapsible soils and slope instability, which summarize all available information for further interpretation. The 1:2.500.000 scale composite geohazard main map provides a valuable tool for initial assessment and review in early planning stages of land development projects.
Macroscopic Pure State of Light Free of Polarization Noise
Creators: name: Iskhakov, Timur Sh.
name: Chekhova, Maria V.
name: Rytikov, Georgy O.
name: Leuchs, Gerd
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The preparation of completely non-polarized light is seemingly easy: an everyday example is sunlight. The task is much more difficult if light has to be in a pure quantum state, as required by most quantum-technology applications. The pure quantum states of light obtained so far are either polarized or, in rare cases, manifest hidden polarization: even if their intensities are invariant to polarization transformations, higher-order moments are not. We experimentally demonstrate the preparation of the macroscopic singlet Bell state, which is pure, completely non-polarized, and has no polarization noise. Simultaneous fluctuation suppression in three Stokes observables below the shot-noise limit is demonstrated, opening perspectives for noiseless polarization measurements. The state is shown to be invariant to polarization transformations. This robust highly entangled isotropic state promises to fuel important applications in photonic quantum technologies.
description: 4 pages, 2 figures, 1 table
Seabed sediments of Søre Sunnmøre, Norway
Creators: name: Elvenes, Sigrid
name: Bøe, Reidulv
name: Lepland, Aave
name: Dolan, Margaret
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: An increasing number of activities compete for space in the Norwegian coastal zone, making access to detailed seabed information particularly valuable. We present a suite of thematic marine base maps of the near-shore areas of five municipalities in west Norway (567 km2; at 62°N/5°E). This set of full-coverage seabed maps includes sediment grain size, seabed terrain (shaded relief), slope, sediment accumulation basins, anchoring conditions, and diggability (trenching properties). The sediment grain size map is a geological interpretation of multibeam echosounder data supported by video observations and physical samples of seabed sediments. The other maps in the suite are derived from this sediment map, and/or directly from the bathymetry data. All maps are at a scale of 1:20,000 and are freely accessible for download or online viewing. Marine base maps are intended for all end-users with a need for knowledge of seabed conditions and may be especially valuable for marine spatial planning.
TimeSeriesStreaming.vi: LabVIEW program for reliable data streaming of large analog time series
Creators: name: Czerwinski, Fabian
name: Oddershede, Lene B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: With modern data acquisition devices that work fast and very precise, scientists often face the task of dealing with huge amounts of data. These need to be rapidly processed and stored onto a hard disk. We present a LabVIEW program which reliably streams analog time series of MHz sampling. Its run time has virtually no limitation. We explicitly show how to use the program to extract time series from two experiments: For a photodiode detection system that tracks the position of an optically trapped particle and for a measurement of ionic current through a glass capillary. The program is easy to use and versatile as the input can be any type of analog signal. Also, the data streaming software is simple, highly reliable, and can be easily customized to include, e.g., real-time power spectral analysis and Allan variance noise quantification.
description: 11 pages, 4 figures, program URL: http://www.nbi.dk/~czerwin/TimeSeriesStreaming.html
Validation and Classification of the 9-Item Voice Handicap Index (VHI-9i)
Creators: name: Caffier, Felix
name: Nawka, Tadeus
name: Neumann, Konrad
name: Seipelt, Matthias
name: Caffier, Philipp P.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Voice Handicap Index (VHI-9i)
subject: international short scale
subject: VHI-9i severity levels
subject: test-retest reliability
subject: validation of classification ranges
subject: self-assessed vocal impairment (VHIs)
subject: hoarseness
subject: dysphonia severity categories
subject: voice diagnostics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The international nine-item Voice Handicap Index (VHI-9i) is a clinically established short-scale version of the original VHI, quantifying the patients’ self-assessed vocal handicap. However, the current vocal impairment classification is based on percentiles. The main goals of this study were to establish test–retest reliability and a sound statistical basis for VHI-9i severity levels. Between 2009 and 2021, 17,660 consecutive cases were documented. A total of 416 test–retest pairs and 3661 unique cases with complete multidimensional voice diagnostics were statistically analyzed. Classification candidates were the overall self-assessed vocal impairment (VHIs) on a four-point Likert scale, the dysphonia severity index (DSI), the vocal extent measure (VEM), and the auditory–perceptual evaluation (GRB scale). The test–retest correlation of VHI-9i total scores was very high (r = 0.919, p < 0.01). Reliability was excellent regardless of gender or professional voice use, with negligible dependency on age. The VHIs correlated best with the VHI-9i, whereas statistical calculations proved that DSI, VEM, and GRB are unsuitable classification criteria. Based on ROC analysis, we suggest modifying the former VHI-9i severity categories as follows: 0 (healthy): 0 ≤ 7; 1 (mild): 8 ≤ 16; 2 (moderate): 17 ≤ 26; and 3 (severe): 27 ≤ 36.
Tensor-optimized few-body model for s-shell nuclei
Creators: name: Horii, Kaori
name: Toki, Hiroshi
name: Myo, Takayuki
name: Ikeda, Kiyomi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: As a new scheme of treating the tensor interaction of the nucleon-nucleon interaction, there is a proposal of a tensor-optimized shell-model (TOSM) for the study of medium and heavy nuclei. The TOSM includes the deuteron-like tensor correlation and provides quite a good reproduction of the binding energy and the size of $^4$He as compared with rigorous few body calculations. We propose a tensor-optimized few-body model (TOFM) using the spirit of the TOSM approximation in the few body framework with bare nucleon-nucleon interaction. We find that the TOFM can account for the strength of the tensor interaction very well and almost reproduces the full energy and various energy components as compared with rigorous few body calculations.
description: 4 pages, 2 figures and 2 tables
Seabed classification around Lampione islet, Pelagie Islands Marine Protected area, Sicily Channel, Mediterranean Sea
Creators: name: Innangi, Sara
name: Di Martino, Gabriella
name: Romagnoli, Claudia
name: Tonielli, Renato
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry

description: We present the first seabed map of the shallow-water areas of Lampione, the islet of the Pelagie Islands Marine Protected Area (Sicily Channel, Italy). The seafloor was mapped from the coast to a depth of about 75 m, using high-resolution multibeam systems (both for bathymetry and backscatter) along with ground-truth data in the form of grab samples and ROV video-observations. By integrating these original data, a first seabed classification was produced through the use of the Remote Sensing Object Based Image Analysis, a semi-automatic segmentation approach. The resulting 1: 5.000 scale map includes sediment types and habitat distribution contributing to the knowledge of the peculiar marine ecosystem observed at Lampione. In particular, the map provides the first indication of the wide occurrence of rhodolith/maërl habitats at Lampione, which are among the most important ecosystems in the Mediterranean Sea.
How Are Techno-Stressors Associated with Mental Health and Work Outcomes? A Systematic Review of Occupational Exposure to Information and Communication Technologies within the Technostress Model
Creators: name: Borle, Prem
name: Reichel, Kathrin
name: Niebuhr, Fiona
name: Voelter-Mahlknecht, Susanne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: digitalisation
subject: ICT demands
subject: workplace well-being
subject: knowledge workers
subject: platform work
subject: sociotechnical systems
subject: methodology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The technostress model has introduced different factors to consider when assessing how information and communication technologies impact individuals in different work settings. This systematic review gathers evidence regarding associations between occupational exposure to technostress and health or work outcomes. In addition, we highlight typical methodological constraints of the technostress model. We conducted electronic literature searches in June 2020 (PubMed, PubMed Central, Web of Science, Scopus, PsycInfo, PsycArticles) and independently screened 321 articles. We report on 21 articles meeting eligibility criteria (working population, technostress exposure, health or work outcome, quantitative design). The most frequently examined techno-stressors, i.e., factors of technostress, were techno-overload and techno-invasion. Techno-stressors were consistently associated with adverse health and work outcomes, apart from a positive impact on work engagement. However, studies may be subject to considerable conceptual overlap between exposure and outcome measures. Future technostress research would benefit from reducing heterogeneity in technostress measures, assessing their external validity and focussing on specific techno-stressors.
MPEC 2023-X153 : 2023 XL4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 XL4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Geomorphology of Las Derrumbadas dome complex, Puebla Mexico
Creators: name: Muñiz-Jáuregui, J. A.
name: Guzmán-Cervantes, C. S.
name: Garduño-Monroy, V. H.
name: Jiménez-Haro, A.
name: Layer, P.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: This paper comprises a geomorphologic map of the Las Derrumbadas (LDR) volcanic complex in Mexico. The complex stretches over more than 285 km2, the stratigraphic column encompasses a range age from Cretacious to Quaternary. The methodology used involved the analysis of digital morphometric models, satellite imagery and absolute datings. The result is a 1:40,000 scale map, which is divided into two large geomorphologic groups in terms of the dominant processes: exogenic and endogenic This, in turn, are divided into various subgroups representing the morphological complexity of the study area, principally related to volcanic processes and their coherence with slope processes.
Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells
Creators: name: Simon, Michèle
name: Lücht, Christian
name: Hosp, Isa
name: Zhao, Hongfan
name: Wu, Dashan
name: Heidecke, Harald
name: Witowski, Janusz
name: Budde, Klemens
name: Riemekasten, Gabriela
name: Catar, Rusan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: systemic sclerosis
subject: scleroderma renal crisis
subject: PAR-1 receptor
subject: IL-6
subject: autoantibodies
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background. Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc). Autoantibodies (Abs) against endothelial cell antigens have been implicated in SSc and SRC. However, their detailed roles remain poorly defined. Pro-inflammatory cytokine interleukin-6 (IL-6) has been found to be increased in SSc, but its role in SRC is unclear. Here, we aimed to determine how the autoantibodies from patients with SSc and SRC affect IL-6 secretion by micro-vascular endothelial cells (HMECs). Methods. Serum IgG fractions were isolated from either SSc patients with SRC (n = 4) or healthy individuals (n = 4) and then each experiment with HMECs was performed with SSc-IgG from a separate patient or separate healthy control. IL-6 expression and release by HMECs was assessed by quantitative reverse transcription and quantitative PCR (RT-qPCR) and immunoassays, respectively. The mechanisms underlying the production of IL-6 were analyzed by transient HMEC transfections with IL-6 promoter constructs, electrophoretic mobility shift assays, Western blots and flow cytometry. Results. Exposure of HMECs to IgG from SSc patients, but not from healthy controls, resulted in a time- and dose-dependent increase in IL-6 secretion, which was associated with increased AKT, p70S6K, and ERK1/2 signalling, as well as increased c-FOS/AP-1 transcriptional activity. All these effects could be reduced by the blockade of the endothelial PAR-1 receptor and/or c-FOS/AP-1silencing. Conclusions. Autoantibodies against PAR-1 found in patients with SSc and SRC induce IL-6 production by endothelial cells through signalling pathways controlled by the AP-1 transcription factor. These observations offer a greater understanding of adverse endothelial cell responses to autoantibodies present in patients with SRC.
Geomorphology of the northern sector of the Alfambra-Teruel depression (Iberian ranges, NE Spain)
Creators: name: Sánchez-Fabre, Miguel
name: Peña-Monné, José Luis
name: Sampietro-Vattuone, María Marta
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: The area of Alfambra (NE Spain) is very representative of the relief evolution of the Eastern Iberian ranges. The geomorphological cartography (Main Map) includes the northern sector of the Alfambra-Teruel Neogene depression and its mountainous surroundings. The cartographic process started by using aerial photographs (1:30000 scale) and fieldwork. The structural reliefs, erosion surfaces, karst landforms, Quaternary pediments and terraces, and fluvial network are represented over a lithological background. The main cartography is complemented with two maps of lithological and geomorphological units. The obtained information enabled the main geological and geomorphological stages of the regional relief to be established.
Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice
Creators: name: Marbach-Breitrück, Eugenia
name: Rohwer, Nadine
name: Infante-Duarte, Carmen
name: Romero-Suarez, Silvina
name: Labuz, Dominika
name: Machelska, Halina
name: Kutzner, Laura
name: Schebb, Nils Helge
name: Rothe, Michael
name: Reddanna, Pallu
name: Weylandt, Karsten H.
name: Wieler, Lothar H.
name: Heydeck, Dagmar
name: Kuhn, Hartmut
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: eicosanoids
subject: lipoxygenase
subject: inflammation
subject: pain
subject: leukotrienes
subject: resolvins
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating wildtype enzyme. These mice were leukotriene deficient but exhibited an elevated linoleic acid oxygenase activity. Here we characterized the polyenoic fatty acid metabolism of these mice in more detail and tested the animals in three different experimental inflammation models. In experimental autoimmune encephalomyelitis (EAE), Alox5-KI mice displayed an earlier disease onset and a significantly higher cumulative incidence rate than wildtype controls but the clinical score kinetics were not significantly different. In dextran sodium sulfate-induced colitis (DSS) and in the chronic constriction nerve injury model (CCI), Alox5-KI mice performed like wildtype controls with similar genetic background. These results were somewhat surprising since in previous loss-of-function studies targeting leukotriene biosynthesis (Alox5(-/-) mice, inhibitor studies), more severe inflammatory symptoms were observed in the EAE model but the degree of inflammation in DSS colitis was attenuated. Taken together, our data indicate that these mutant Alox5-KI mice respond differently in two models of experimental inflammation than Alox5(-/-) animals tested previously in similar experimental setups.
Application of a Localized Chaos Generated by RF-Phase Modulations in Phase-Space Dilution
Creators: name: Lee, S. Y.
name: Ng, K. Y.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Physics of chaos in a localized phase-space region is exploited to produce a longitudinally uniformly distributed beam. Theoretical study and %numerical simulations are used to study its origin and applicability in phase-space dilution of beam bunch. Through phase modulation to a double-rf system, a central region of localized chaos bounded by invariant tori are generated by overlapping parametric resonances. Condition and stability of the chaos will be analyzed. Applications include high-power beam, beam distribution uniformization, and industrial beam irradiation.
description: 6 pages including 1 cover, 15 figures
Immunoinformatics-guided designing and in silico analysis of epitope-based polyvalent vaccines against multiple strains of human coronavirus (HCoV)
Creators: name: Sarkar, Bishajit
name: Ullah, Md. Asad
name: Araf, Yusha
name: Islam, Nafisa Nawal
name: Zohora, Umme Salma
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The group of human coronaviruses (HCoVs) consists of some highly pathogenic viruses that have caused several outbreaks in the past. The newly emerged strain of HCoV, the SARS-CoV-2 is responsible for the recent global pandemic that has already caused the death of hundreds of thousands of people due to the lack of effective therapeutic options. In this study, immunoinformatics methods were used to design epitope-based polyvalent vaccines which are expected to be effective against four different pathogenic strains of HCoV i.e., HCoV-OC43, HCoV-SARS, HCoV-MERS, and SARS-CoV-2. The constructed vaccines consist of highly antigenic, non-allergenic, nontoxic, conserved, and non-homologous T-cell and B-cell epitopes from all the four viral strains. Therefore, they should be able to provide strong protection against all these strains. Protein-protein docking was performed to predict the best vaccine construct. Later, the MD simulation and immune simulation of the best vaccine construct also predicted satisfactory results. Finally, in silico cloning was performed to develop a mass production strategy of the vaccine. If satisfactory results are achieved in further in vivo and in vitro studies, then the vaccines designed in this study might be effective as preventative measures against the selected HCoV strains.
The Herschel revolution: unveiling the morphology of the high mass star formation sites N44 and N63 in the LMC
Creators: name: Hony, S.
name: Galliano, F.
name: Madden, S. C.
name: Panuzzo, P.
name: Meixner, M.
name: Engelbracht, C.
name: Misselt, K.
name: Galametz, M.
name: Sauvage, M.
name: Roman-Duval, J.
name: Gordon, K.
name: Lawton, B.
name: Bernard, J. -P.
name: Bolatto, A.
name: Okumura, K.
name: Chen, C. -H. R.
name: Indebetouw, R.
name: Israel, F. P.
name: Kwon, E.
name: Li, A.
name: Kemper, F.
name: Oey, M. S.
name: Rubio, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the structure of the medium surrounding sites of high-mass star formation to determine the interrelation between the HII regions and the environment from which they were formed. The density distribution of the surroundings is key in determining how the radiation of the newly formed stars interacts with the surrounds in a way that allows it to be used as a star formation tracer. We present new Herschel/SPIRE 250, 350 and 500 mum data of LHA 120-N44 and LHA 120-N63 in the LMC. We construct average spectral energy distributions (SEDs) for annuli centered on the IR bright part of the star formation sites. The annuli cover ~10-~100 pc. We use a phenomenological dust model to fit these SEDs to derive the dust column densities, characterise the incident radiation field and the abundance of polycyclic aromatic hydrocarbon molecules. We see a factor 5 decrease in the radiation field energy density as a function of radial distance around N63. N44 does not show a systematic trend. We construct a simple geometrical model to derive the 3-D density profile of the surroundings of these two regions. Herschel/SPIRE data have proven very efficient in deriving the dust mass distribution. We find that the radiation field in the two sources behaves very differently. N63 is more or less spherically symmetric and the average radiation field drops with distance. N44 shows no systematic decrease of the radiation intensity which is probably due to the inhomogeneity of the surrounding molecular material and to the complex distribution of several star forming clusters in the region.
description: Accepted for publication in A&A letters (Herschel special issue)
How the Fungi got into shape : cellular organization and morphogenetic gene evolution in phylum Chytridiomycota reveals mechanisms underlying the evolution of fungal body diversity
Creators: name: Dee, Jaclyn Marie
Publisher: name: University of British Columbia
Year: 2018

description: With their threadlike hyphal cells, fungi can invade the surface of a cheese, secreting digestive enzymes and soaking up the spoils. Although most fungi feed with hyphae, phylum Chytridiomycota produces various alternative cell shapes. Here I address three hypotheses regarding the evolution of cell shape. Firstly, Fungi inherited core genes for cellular morphogenesis from their most recent common ancestor and diversification of these genes through evolutionary time potentially contributed to morphological novelty. My phylogenomic surveys revealed duplications in seven families of actin-binding proteins predating the radiation of fungal phyla. Synthesizing previous studies of the function, localization and evolutionary history of septin, myosin, and actin-binding proteins in yeasts and hyphal fungi enabled me to further hypothesize their roles during development in Chytridiomycota. Since Chytridiomycota diverged from moulds and mushrooms, each group evolved unique mechanisms for constructing different cell shapes using a shared ancestral molecular toolkit. Hyphal growth and septation require actin. My second hypothesis was that actin, a major cytoskeletal component, is also involved in morphogenesis in Chytridiomycota. Using fluorescence microscopy, I documented rhodamine phalloidin-stained actin cables, patches, sheets and perinuclear shells through development in Chytriomyces hyalinus. I disrupted the actin cytoskeleton with the chemical inhibitor latrunculin B. Observing actin patches concentrated at rhizoid tips and at cytoplasmic cleavage planes, and finding that actin integrity was essential for rhizoid proliferation in C. hyalinus both support a conserved role for actin in polarized growth and cytokinesis. Thirdly, I hypothesized that sustained tip growth and nuclear migration underlie the convergent evolution of hyphae and hypha-like growth forms. Chytriomyces hyalinus shows determinate growth that ceases once a zoosporangium matures. Phylogenies indicate that filamentous species in Chytridiomycota with indeterminate growth arose independently from ancestors with a determinate growth mode. I determined that actin organization and nuclear migration patterns in each species differed from one another and from hyphae, most likely as a result of their independent origins. In combination, phylogenetic analyses, molecular genetics, and microscopy are tearing away the curtains of time that mask the ever-changing molecular machinery that gave rise to an astounding diversity of form and function in modern fungi.
Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells
Creators: name: Zhu, Jiaqi
name: Langer, Peter
name: Ulrich, Claas
name: Eberle, Jürgen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: cutaneous SCC
subject: indirubin
subject: apoptosis
subject: reactive oxygen species (ROS)
subject: antioxidants
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before. Here, we investigated the efficacy of three indirubin derivatives (DKP-071, -073 and -184) in four cSCC cell lines. High efficacy was seen in SCL-I, SCL-II, SCC-12 and SCC-13, resulting in up to 80% loss of cell proliferation, 60% loss of cell viability and 30% induced apoptosis (10 µM). Apoptosis was further enhanced in combinations with TNF-related apoptosis-inducing ligand (TRAIL). Induction of reactive oxygen species (ROS) appeared as critical for these effects. Thus, antioxidative pretreatment completely abolished apoptosis as well as restored cell proliferation and viability. Concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic PKCδ (protein kinase C delta), inhibition of STAT3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic XIAP (X-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic Bcl-2 protein Puma and the cell cycle inhibitor p21 were obtained. Importantly, all activation steps were prevented by antioxidants, thus proving ROS as a master regulator of indirubins’ antitumor effects. ROS induction presently develops as an important issue in anticancer therapy.
31908: Looking for the silver linings
Creators: name: Project, Lockdown2020 and Beyond
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: Far too much evening and weekend working supporting staff from across the Medical Sciences Division in moving their teaching online - despite the frantic pace of work, there is a monotony to work and life, often lived through Teams or Zoom. However: - we have enough space for my wife and I, and our four children to work, each in our own space; - the ethical broadband we have is just about holding up; - we are all well and everyone we know is fine; - we have a garden; - the weather's been lovely and the days are long enough that there's still plenty of light and warmth in the day after work; - and my son is still over the moon at not having to sit GCSEs. The high point of every day is taking the dog for a walk on Port Meadow and in Burgess Field with one or more children - really appreciating the opportunity to notice nature and the seasons in a way that I haven't done since I was a child, and the extra time with our children, particularly the youngest, who comes with me on most walks. Weekends without adult or child activities now yield time for board games, kitchen table tennis, making elderflower cordial, family artworks, reading, etc...as well as the fighting, screaming, tears and laughter that are inevitable when a family of six spend so long together in the same space.