cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity
Creators: name: Metushi, Imir G.
name: Wriston, Amanda
name: Banerjee, Priyanka
name: Gohlke, Bjoern Oliver
name: English, A. Michelle
name: Lucas, Andrew
name: Moore, Carrie
name: Sidney, John
name: Buus, Soren
name: Ostrov, David A.
name: Mallal, Simon
name: Phillips, Elizabeth
name: Shabanowitz, Jeffrey
name: Hunt, Donald F.
name: Preissner, Robert
name: Peters, Bjoern
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir- induced hypersensitivity syndrome is a CD8+ T cell dependent IM-ADR that is exclusively mediated by HLA-B*57:01. We and others have previously shown that abacavir can occupy the floor of the peptide binding groove of HLA-B*57:01 molecules, increasing the affinity of certain self peptides resulting in an altered peptide-binding repertoire. Here, we have identified another drug, acyclovir, which appears to act in a similar fashion. As with abacavir, acyclovir showed a dose dependent increase in affinity for peptides with valine and isoleucine at their C-terminus. In agreement with the binding studies, HLA-B*57:01 peptide-elution studies performed in the presence of acyclovir revealed an increased number of endogenously bound peptides with a C-terminal isoleucine. Accordingly, we have hypothesized that acyclovir acts by the same mechanism as abacavir, although our data also suggest the overall effect is much smaller: the largest changes of peptide affinity for acyclovir were 2-5 fold, whereas for abacavir this effect was as much as 1000-fold. Unlike abacavir, acyclovir is not known to cause IM-ADRs. We conclude that the modest effect of acyclovir on HLA binding affinity in contrast to the large effect of abacavir is insufficient to trigger a hypersensitivity syndrome. We further support this by functional in vitro studies where acyclovir, unlike abacavir, was unable to produce an increase in IFN-γ upon expansion of HLA-B*57:01+ PBMCs from healthy donors. Using abacavir and acyclovir as examples we therefore propose an in vitro pre-clinical screening strategy, whereby thresholds can be applied to MHC-peptide binding assays to determine the likelihood that a drug could cause a clinically relevant IM-ADR.
Opportunities and challenges to connecting creators and consumers online
Creators: name: Hutley, Vanessa
Publisher: name: Swinburne
Year: 2024

description: Over the past decade Australia's digital economy has become a key driver of national productivity, employment and social well-being. The online landscape is providing exciting new ways for Australians to connect with each other and for businesses to deliver new, more efficient and better services to consumers. Within this digital revolution, Australia's copyright industries play a significant role in generating the content carried through the digital pipelines. These industries are at the frontline of innovation as they develop new content, new businesses and business models to deliver entertainment and information to Australian consumers. However, while the Internet, and particularly the promise of the National Broadband Network, brings with it great opportunity, it also carries many challenges. This paper discusses the challenge of online copyright theft to ongoing Australian innovation and culture and considers possible solutions that may materialise in the near future, particularly on the back of recent positive announcements in the United States.
Perceptions of efficacy of gifted young women in different learning environments.
Creators: name: Navan, Joy L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Women's Studies.

description: The primary purpose of this study was to determine perceptions of academic efficacy of gifted young women in three different learning environments---a public high school, an early college entrance program and a private high school affiliated with the Coalition for Essential Schools. The second purpose of the study was to ascertain which factors in the learning environments influenced the students' perceptions of academic efficacy. The participants in the study were twenty gifted high school females in Grades 11 or 12, and, in the case of the early entrance program, in their first year of college. All were studying in the northeastern United States. The qualitative design of the study entailed an emerging analysis of data gathered through separate focus groups in each environment, close observation of the students in the environments, and reconvening the participants in a follow-up focus group. In addition, individual reflective assessments completed by participants and interviews with the directors of the programs provided triangulation data. A computer-assisted analysis of the data for each site was followed with analysis across-sites, from which emerged significant themes and constructs regarding efficacy and learning environments. Results of the study indicated that gifted young women have perceptions of academic efficacy that differed in the different learning environments. All students reported perceptions of strong academic efficacy. Students in the public high school perceived themselves strongest in specific subject matter efficacy. Young women in the early entrance program revealed strong global self-efficacy as well as an emerging sense of self-agency. Gifted young women in the private high school demonstrated significant metacognitive efficacy. Consistent with social learning theory, students' perceptions, behaviors and environments were reciprocally influenced in each of the learning climates. In addition, analysis revealed significant findings regarding early perceptions of intelligence and placement in the family constellation. The concluding chapters examine major themes and constructs that emerged regarding the psychosocial development of gifted young women and how learning environments can assist their development more effectively.
Posgrado Curso Visibilidad - Modulo 3 - Taller 1
Creators: name: MORENATE, RA.
Publisher: name: Zenodo
Year: 2020
Subjects: visibilidad de los investigadores y sus producciones
cienciasnea
fhycs unam argentina
ra morenate

description: Posgrado visibilidad de las producciones científicas y sus autores
Planet 9: Rhea - A Comprehensive Analysis Based on the Light-Pi Framework
Creators: name: Needham, Eric
Publisher: name: Zenodo
Year: 2025
Subjects: Planet 9
Trans-Neptunian Object
Rhea
φπ-scaling
Light-Pi Framework
Recursive cosmology
Vacuum emergence
Orbital shell model
Sub-Neptunian planet
JWST prediction
Cold gas giant
Cryogenic atmosphere
Scalar harmonic resonance
ENSO Project

description: This paper presents a novel, fully theoretical prediction of a trans-Neptunian planet—named Rhea—derived using the Light-Pi Framework, a recursive cosmological model grounded in φπ-scaling and emergent vacuum structure. Rhea is predicted to reside in the N₀+18 orbital shell at approximately 480 AU with an orbital period of ~10,520 years and a mass of ~0.687 Earth masses.

Unlike prior empirical searches, this prediction is based entirely on first principles, without post hoc curve fitting or observational adjustment. The paper details the predicted mass, orbital dynamics, atmospheric composition, and internal structure of the planet, as well as precise RA/Dec coordinates for JWST visibility during October 11–22, 2025.

Visual and mathematical models are included, alongside an artistic rendering consistent with predicted high winds, methane storms, and cryogenic weather bands. The paper represents a testable, timestamped assertion of planetary emergence driven by vacuum harmonic resonance—placing Rhea as the first theoretically derived planetary body of the 21st century.

Author: Eric NeedhamProject: The ENSO Framework, 2025

If you would like more information about the ENSO Framework, contact Eric Needham: ensotheory1@gmail.com
Prevalence of mental health disorders in inflammatory bowel disease: An Australian outpatient cohort
Creators: name: Tribbick, Davina
name: Salzberg, Michael
name: Ftanou, Maria
name: Connell, William
name: Macrae, Finlay
name: Kamm, Michael
name: Bates, Glen
name: Cunningham, Georgina
name: Austin, David
name: Knowles, Simon
Publisher: name: Swinburne
Year: 2024

description: This study aimed to characterize prevalence of anxiety and depressive conditions and uptake of mental health services in an Australian inflammatory bowel disease (IBD) outpatient setting.
Design and implementation of a policy management in an agent-based system.
Creators: name: Guennoun, Mouhcine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Engineering, Electronics and Electrical.

description: Personal Mobility Management System, a distributed application developed at the Multimedia & Mobile Agent Research Laboratory, allows users to move across a virtual network of predefined sites. Each site provides personalized services to its visitors. The purpose of this thesis is to introduce an agent-based architecture to create and manage policies on each site involved in the virtual network. The architecture defines an administrative infrastructure that allows each site to restrict access to the local resources and to sensitive information by visiting users. These restrictions are expressed in terms of policies that are stored in a policy server at each site. Policies are also related to the privacy and ownership levels attached to resources as well as to profiles of visiting users. The thesis presents a model to detect conflicts that may occur between different agents as a result of rules imposed by different policies. These conflicts are resolved through negotiation between agents.
Preparation, characterization and reactivity of mono- and dinuclear silica-supported titanium(IV) complexes.
Creators: name: Bouh, Abdillahi Omar.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Chemistry, Physical.

description: This thesis deals with the preparation, characterization and reactivity of silica-supported titanium(IV) complexes. The room temperature reactions of excess Ti(OiPr)4 with the hydroxyl groups of a nonporous silica yield dinuclear surface complexes regardless of the degree of partial dehydroxylation of the silica. The surface reactions were studied by in situ IR transmission spectroscopy, DRUV-vis, 13C CP/MAS NMR, GC/MS and elemental analysis. The spontaneous stoichiometric formation of both 2-propanol and propene during grafting indicates that interaction of Ti(OiPr)4 with the silica surface induces disproportionation of alkoxide ligands with concomitant formation of a Ti-O-Ti bridge. A synthetic route to mononuclear silica-supported Ti alkoxide complexes was developed by reaction of grafted amide complexes (≡SiO)nTi(NEt 2)4-n (n = 1 or 2) with alcohols. Subsequent reactions of the mononuclear surface alkoxide complexes with Ti(OiPr) 4 yield dinuclear species identical to those prepared by the direct reaction of Ti(OiPr)4 with silica. Both mono- and dinuclear supported alkoxide complexes undergo ligand exchange reactions with tert-butylhydroperoxide, but only the dinuclear alkylperoxo titanium surface complexes react with olefins to generate epoxides, which are formed quantitatively as the exclusive product at short reaction times. At longer contact times, the yield of epoxide decreases, without the appearance of other volatile oxidation products. It was discovered that the epoxide reacts with the catalyst and the product blocks the active site, inhibiting further epoxidation reaction with tert-butylhydroperoxide.
Laser shadowgraph study of early flame propagation in swirling flows near the lean misfire limit.
Creators: name: Sheikhi, Abdolreza.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Automotive.

description: The effects of swirling flow and spark locations on the specific rate of growth of flame area, the flame speed and the convection velocity are investigated experimentally in a constant volume vessel near the lean misfire limit for an equivalence ratio of 0.645 using the shadowgraph technique. The circular and the elliptical models are used as flame contours to calculate the flame speed and the convection velocity. The circular model indicates that the flame speed decreases as the swirl flow decays and as the spark location is moved towards the center of the combustion chamber. The modified elliptical model shows the same result for the average flame speed $S\sb{ws}$. Both models show an overlap in convection velocity when comparison is made at a given spark location for different swirl levels because of cyclic variation; even though the average is higher for higher swirl level. The specific rate of growth of flame area (${1\over A}{dA\over dt}$) is obtained using three models for flame area A: (i) 2-D flame area $A\sb{f}$ measured from the photographs, (ii) spherical flame geometry model, and (iii) ellipsoidal geometry model. The stretch factor $K=({\delta\sb{l}\over u\sb{l}}) ({1\over A}{dA\over dt})$ at 0.5 ms from ignition time for the 2-D and the spherical models at ${r\over R}=0.68$ was within the range 0.63-0.97 and at ${r\over R}=0.55$ was within the range 0.5-0.59. The stretch factor for the ellipsoidal model at ${r\over R}=0.68$ was within the range 0.53-1.05 and at ${r\over R}=0.55$ was within the range 0.46-0.53. All three models for flame area indicate that the specific rate of growth of flame area and stretch factor at 0.5 ms from ignition time decrease as the swirl flow decays and as the spark location approaches the center of the combustion chamber.
title: Parabens in urine of children and adolescents in Germany - human biomonitoring results of the german environmental survey 2014-2017 (GerES V)
title: Parabens in urine of children and adolescents in Germany
titleType: AlternativeTitle
Creators: name: Kolossa-Gehring, Marike
name: Murawski, Aline
name: Tschersich, Carolin
name: Rucic, Enrico
name: Schwedler, Gerda
Publisher: name: My University
Year: 2020
Subjects: Endokrin wirksame Substanz
Exposition

description: Parabens are antimicrobial preservatives used in a wide range of consumer products such as personal care products, cosmetics, pharmaceuticals, and food. Consequently, the general population is ubiquitously exposed to these substances via dermal absorption, ingestion, and inhalation. Parabens promote estrogenic activity and are hence under assessment as endocrine disrupting substances. Urine samples from 3- to 17-year-old children and adolescents (N = 516) living in Germany were analysed for concentrations of nine parabens in the population representative German Environmental Survey for Children and Adolescents 2014-2017 (GerES V). Detection rates and urinary concentrations of the parabens decreased with increasing length of the alkyl chain. Methyl paraben was quantified in 97% of the samples with a geometric mean (GM) concentration of 7.724 (my)g/L (6.714 (my)g/gcreatinine), ethyl paraben was quantified in 69% (GM: 0.943 (my)g/L and 0.825 (my)g/gcrea), and n-propyl paraben in 31% (GM: 0.563 (my)g/L and 0.493 (my)g/gcrea). Concentrations of iso-propyl paraben, butyl paraben, iso-butyl paraben, and benzyl paraben were below the limit of quantification in most samples. Pentyl paraben and heptyl paraben were not detected in any of the samples. Paraben concentrations in urine were found to be associated with frequent usage of leave-on personal care products and cosmetics. Cumulative exposure to parabens (back-calculated daily intakes, expressed as hazard index) was found to be on a level raising concern in up to 14% of the population, mainly driven by n-propyl paraben, and depending on the level of conservativeness and point-of departures used for calculation. © 2020 The Author(s)
Palladium catalyzed thiocarbonylation and related reactions of functionally substituted alkenes and alkynes, allenes, and enynes.
Creators: name: Xiao, Wen-Jing.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Chemistry, Organic.

description: A systematic investigation has been carried out on the palladium-catalyzed thiocarbonylation and related reactions of unsaturated substrates such as propargylic and allylic alcohols, 1,2- and 1,3-dienes, and conjugated enynes with thiols and carbon monoxide. It has been first demonstrated that the reaction of allylic alcohols with thiols and CO in the presence of catalytic quantities of Pd(OAc) 2 (3 mol%), triphenylphosphine (12 mol%), and p-TsOH (5 mol%) leads to a novel reaction, namely thiocarbonylation, to afford beta,gamma-usaturated thiol esters in good to excellent yields. Other catalyst systems such as Pd 2(dba)3·CHCl3/PPh3/p-TsOH, Pd(PPh 3)4/p-TsOH, and Pd(OAC)2/dppb/ p-TsOH are also effective for this transformation. The thiocarbonylation reaction is believed to proceed via a eta3-allylpalladium intermediate. The reaction occurs in a highly regioselective manner, at the least hindered allylic terminal carbon of the substrate, to give the products. The new carbonylation procedure was readily applied to a variety of allylic alcohols, and to both aromatic and aliphatic thiols. Palladium (0) as well as palladium (II) complexes with added phosphine ligands catalyze the thiocarbonylation of propargylic compounds. Depending on the reaction conditions employed, the reaction can afford mono- and di-thioesters or beta-thio-substituted gamma-lactones as the principal products in good yields, respectively. Thus, in the presence of 3 mol% of Pd(OAC)2, 5 mol% of p-TsOH, and 12 mol% of PPh3, propargylic alcohols react with thiols in THF under 400 psi of carbon monoxide at 100°C to give monothioesters in excellent yields. beta-Thio-alpha,beta-unsaturated-gamma-lactones can be prepared in high yields by the thiolactonization of propargylic alcohols using Pd(PPh3)4 as the catalyst and DME as the solvent. Propargylic mesylates undergo dithiocarbonylation when they are treated with catalytic amounts of Pd(PPh3)4. This reaction exclusively gives dithioesters under milder conditions (90°C, 400 psi). A series of mono- and di-substituted allenes undergo direct thiocarbonylation with thiols and carbon monoxide to form the corresponding unsaturated thioesters in 73--94% isolated yields. This reaction requires catalytic quantities of Pd(OAC)2 (3 mol%) and triphenylphosphine (12 mol%) in THF under an atmosphere of CO (400 psi) at 100°C for 48 h. The reaction is believed to proceed via pi-allylpalladium complex. The reaction exhibits high regioselectivity, in which the thiophenyl group adds to the less substituted double bond of allenes. (Abstract shortened by UMI.)
Prevalence and Factors Associated with Depression among Elderly in San Ton Kok Village, Chiang Rai, Thailand
Creators: name: Teeraporn Chamroon
Publisher: name: School of Health Science Mae Fah Luang University
Year: 2020
Subjects: Depression
Elderly
Prevalence
factors
Thailand

description: Journal of Health Science and Alternative Medicine, 2, 1, 19-24
A feasibility study to derive two clinical decision rules for patients with urinary calculi: For the use of urgent intravenous pyelography and for predicting complications of delayed urinary calculus passage.
Creators: name: Papa, Linda.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Health Sciences, Medicine and Surgery.

description: Background. About 5--15% of the North American and European populations pass a urinary stone in their lifetime. The most accurate way of detecting degree of urinary obstruction is with a radiograph called an intravenous pyelogram or IVP. Objectives. (1) To assess the feasibility of developing a clinical decision rule that would identify the clinical factors that are sensitive in predicting which patients with suspected ureteral calculi have severe obstruction and require urgent pyelography by: (i) defining severe obstruction; (ii) determining the incidence of severe obstruction; (iii) identifying potential predictor variables; and (iv) calculating a sample size for the definitive decision rule study. (2) To prospectively assess clinical predictors of complications from urinary calculi after discharge from the ED by: (i) determining the incidence of complications; (ii) identifying preliminary predictor variables; (iii) calculating a sample size for the definitive study. (Abstract shortened by UMI.)
Readiness in Response the Epidemic of Coronavirus Disease-2019 (COVID-19) Among Young Adults in Chiang Rai Province, Thailand
Creators: name: Ratipark Tamornpark
Publisher: name: School of Health Science Mae Fah Luang University
Year: 2020
Subjects: COVID-19
Readiness
Knowledge
Perception
Young adult

description: Journal of Health Science and Alternative Medicine, 2, 1, 25-30
La focalización y lo real extraño en la cuentística de Lino Novás Calvo.
Creators: name: Caner Camejo, Asbrúbal.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Literature, Latin American.

description: Lino Novas Calvo (1905--1983) was an outstanding Cuban short-story writer and a pioneer in the modern narrative in his country. I consider point of view as a web of stances that the narrator takes vis-a-vis his narrative world---mainly perceptual and phraseological stances---made possible by a certain status of the narrator, and semiosically contributing to the expression of an ideological stance attributable to the implied or inferred author. My thesis concentrates on the perceptual stance or focalization in three of the most characteristic short stories by Novas Calvo---"La noche de Ramon Yendia", "Cayo Canas" and "La vision de Tamaria"---this stance constituting the central one in the functioning of point of view in Novas Calvo's narrative; the main focus of this stance is triple: character, space and time, and it often produces sequences of a cinematic kind. I also pay close attention to the modes of phraseological stance that generate the principal perceptual-stance phenomenon, namely the mediation of focalization. Coupled to these techniques, I examine the role of Cuban and popular language as well as poetic language. (Abstract shortened by UMI.)
The immunological reactivity of several species of animals to Leptospira pomona and fractions thereof.
Creators: name: Robertson, Alexander.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1962
Subjects: subject: Biology, Microbiology.

description: This investigation had two objectives: (a) to determine the relative susceptibility of several animal species to L. pomona infection and (b) to study the immunological reactivity of guinea pigs and calves to killed suspensions of the organism and fractions thereof. An examination was also made into some of the methods presently used to detect infection or immunity. The relative susceptibility of several animal species to L. pomona infection was compared with that of guinea pigs. Therefore it was first necessary to assay the infectivity of the organism in this species. Bacterial counts were made of young leptospiral culture which was then diluted to provide appropriate dose levels. Sixty guinea pigs in groups of four animals each were injected with infective material ranging down from 100,000 to 13 organisms per inoculum. The level of 50 leptospirae per inoculum was selected as the guinea pig infective dose since it was the lowest in which all animals in the group became infected and showed a regular response. The larger doses of leptospirae did not produce more severe disease as judged by the temperature response. In fact, disease appeared to be less severe at the higher dose but occurred sooner after exposure. Ultimate agglutination-lysis titres not affected by the number of organisms in the infective dose. (Abstract shortened by UMI.)
Intertextualidad y androginia en la literatura posmodernista de Lourdes Ortiz: "Eva", "Salome", "La Liberta", "Urraca" y "Aquiles y Pentesilea"
Creators: name: Meagle-Molina, Elizabeth
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Literature, Modern.
subject: Literature, Romance.

description: This thesis studies five pieces of Spanish postmodern literature, written by the Spanish author Lourdes Ortiz between 1982 and 2001: two historical novels (Urraca and La liberta), two short stories ("Eva" and "Salome", included in the collection Los motivos de Circe), and a play (Aguiles y Pentesilea ). Departing from the notion "intertextuality" and playing with the concepts of "History" and "Truth", these works establish a dialogue with fundamental canonical texts such as the Old and New Testaments, Platonism, Stoicism, and Greco-Roman Mythology. Based on a "metaphysics of essence", Occidental patriarchy has always counted on some extra-textual entity (i.e. God, the Law) that possesses the power of creation, that is, the Word. This misogynist ideology also believes in words' inherent masculine sexuality/textuality, therefore subjugating "feminine" constructs to an insignificant position under the presupposed "masculine" hegemony. This duality has served to maintain a symbolic order that makes a radical distinction between body/soul, "Other"/"I", a distinction which also refers to the opposition between passive women and active men. In these alienating circumstances, Ortiz's works use an ancient figure and tradition labeled as heresy by hegemonic voices: the myth of the androgyne, whose two components are considered equivalents. It is worth noting that despite all violent attempts to suppress this "undesirable counter-narrative", the encounter and transcendence of opposites embodied in this symbol recurs through History in texts such as the Hebrew myth of Lilith, the first chapter of Genesis, the discourse of Aristophanes in Plato's Symposium, and the alchemical notion of the "Purified Androgyne". Confronting orthodox and ex-centric discourses, the works by Lourdes Ortiz reveal, sometimes ironically, some subtle strategies hegemonic discourses employ to appear as a self-sufficient construction. In order to demystify logocentric Master Narratives and vindicate the anti-essentialist nature of the word, the fictions analyzed empower traditionally silenced female voices (Eva, Salome, Acte, Urraca, Pentesilea). These biblical, historical, and mythological women are considered by Ortiz as doers of their own deeds, women that fight to activate their right to negotiate significant and signifying places within the web of texts all individuals are embedded in.
Identifying The Contextual Factors Of Indirect Bullying Situations That Influence Canadian Teachers' Intervention Behaviour
Creators: name: Blain-Arcaro, Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Education, Educational Psychology.

description: Indirect bullying is a form of peer victimization that is observed as frequently occurring in both males and females yet is often overlooked by teachers. Nine bullying situation characteristics were created, which contained 3 to 4 descriptive levels. These bullying situation characteristics were then used to create unique randomly generated questionnaires consisting of 17 unique choice tasks. One hundred and ninety four teachers participated. Using latent class analysis two segments with different influences on intervention were identified. The Group 1 segment teachers (28%) were found to be less influenced by specific information regarding bullies and victims while making intervention decisions and instead assimilated more elements of a bullying situation into consideration. Furthermore, these teachers were found to be more sensitive to covert acts of indirect bullying. The Group 2 segment teachers (72%) decisions were more influenced by the vulnerability of the child who is victimized as well as to physical components of bullying situations. These findings indicate that there is a need for greater focus on the vulnerability of children who bully as well as greater emphasis on indirect bullying within bullying prevention training for teachers.
Romanian supine constructions.
Creators: name: Ionescu, Rodica.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Language, Linguistics.

description: The present research attempts to provide a synchronic syntactic analysis of two Modern Romanian non-finites: the De-Supine and the 'Nominalized' Supine. They are studied in the much debated framework of the similarities and differences between the noun phrase and the sentence. Their external and internal debatable status has been controversial both in early and recent generative grammar. These categories were expected to be so much different and yet very much alike. Their status as two cyclic nodes and two most fundamental categories in every language explains why there has always been an attempt to claim an identical structure for both, to bring them together under a common structure, or to separate them. The present thesis tries to range among recent attempts to provide a common structure for both noun phrase and sentence in the Non-Finite domain. However, by trying to provide the non-finites and the 'nominalized' non-finites with a similar sentential structure, it becomes quite clear and non-derived nouns and 'nominalizations' are quite different structures. The absence of a verbal stem is essential in claiming two complete different structures for them. The attempt of the present study to provide the Romanian Supines with a sentential analysis and structure has been done in the background of three crucial analyses: the analysis of the Balkan IP structures (Joseph, 1983, Rivero, 1988), the DP analysis (Abney, 1987) and the recent analysis of PRO in the Government and Binding framework. Particular emphasis is given to the special nature of PRO as implicit agent identified through Singular in the 'Nominalized' Supine.
Analytical Operations Relate Structural and Functional Connectivity in the Brain
Creators: name: Saggio, Maria Luisa
name: Ritter, Petra
name: Jirsa, Viktor K.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Resting-state large-scale brain models vary in the amount of biological elements they incorporate and in the way they are being tested. One might expect that the more realistic the model is, the closer it should reproduce real functional data. It has been shown, instead, that when linear correlation across long BOLD fMRI time-series is used as a measure for functional connectivity (FC) to compare simulated and real data, a simple model performs just as well, or even better, than more sophisticated ones. The model in question is a simple linear model, which considers the physiological noise that is pervasively present in our brain while it diffuses across the white- matter connections, that is structural connectivity (SC). We deeply investigate this linear model, providing an analytical solution to straightforwardly compute FC from SC without the need of computationally costly simulations of time-series. We provide a few examples how this analytical solution could be used to perform a fast and detailed parameter exploration or to investigate resting-state non-stationarities. Most importantly, by inverting the analytical solution, we propose a method to retrieve information on the anatomical structure directly from functional data. This simple method can be used to complement or guide DTI/DSI and tractography results, especially for a better assessment of inter-hemispheric connections, or to provide an estimate of SC when only functional data are available.
Multiscale Modeling of Bone Healing
Creators: name: Borgiani, Edoardo
name: Duda, Georg N.
name: Checa, Sara
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: bone healing
subject: computer modeling
subject: multiscale modeling
subject: systems biology
subject: tissue regeneration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Bone is a living part of the body that can, in most situations, heal itself after fracture. However, in some situations, healing may fail. Compromised conditions, such as large bone defects, aging, immuno-deficiency, or genetic disorders, might lead to delayed or non-unions. Treatment strategies for those conditions remain a clinical challenge, emphasizing the need to better understand the mechanisms behind endogenous bone regeneration. Bone healing is a complex process that involves the coordination of multiple events at different length and time scales. Computer models have been able to provide great insights into the interactions occurring within and across the different scales (organ, tissue, cellular, intracellular) using different modeling approaches [partial differential equations (PDEs), agent-based models, and finite element techniques]. In this review, we summarize the latest advances in computer models of bone healing with a focus on multiscale approaches and how they have contributed to understand the emergence of tissue formation patterns as a result of processes taking place at the lower length scales.
Groundwater flow system in a mountainous region, Mount Myra, Vancouver Island, British Columbia.
Creators: name: Stapinsky, Martin John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Geology.

description: The objectives of this thesis are to collect baseline data on meteorological and hydrological processes and the geometry and hydrogeological characteristics of the fracture network, in order to improve the knowledge for the development of a site-specific conceptual model of deep groundwater flow systems in British Columbia's mountainous terrain. To reach the objectives of this project, a monitoring network consisting of surface and underground equipment was installed in the Price Mine area, which is located on the Price Hillside of the east flank of Mount Myra, Vancouver Island. Rainfall, air temperature, atmospheric pressure, hydraulic heads in surface and underground drillholes and discharge from mine drifts were measured from August 1994 to June 1997. Also, as part of the project, a structural and hydrogeological mapping of major structural features within Mount Myra's underground workings was carried out to obtain an estimate of the hydrological importance of each geological structure in the Price Mine. The results have demonstrated the large impact of the rainy season on the hydrogeological system on the Price Hillside. Water levels in drillholes, along with discharge, increase drastically at the beginning of the first severe storms during the fall and maintain high levels until the end of the spring. The correlation and spectral analyses of the hydraulic data have shown the fast response of the hydraulic system following rainfall events and indicate that a substantial part of the Price Mine outflow is associated with water circulating in the fracture network intersected by the drillholes located in the fault area. The water levels in drillholes located in more-fractured rocks, near large faults, fluctuated more and showed a strong stormflow component as opposed to water in drillholes located in more-massive rock. In the fault areas in particular, the groundwater flow system adjusts to the rainy season by the upgradient displacement of the hinge point, which is the limit between recharge and discharge areas, in order to cope with this substantial increase in winter recharge. Since the change in groundwater flow appears to occur only in the most fractured areas this observation suggests that the fault zones act as the major flow channels that may control the entire groundwater flow on the Price Hillside. A conceptual model of the hydrogeological system of the Price Hillside was therefore developed on the basis of the observations made during the course of this project. (Abstract shortened by UMI.)
Multi-haul quasi network flow model for vertical alignment optimization
Creators: name: Beiranvand, Vahid
name: Hare, Warren
name: Lucet, Yves
name: Hossain, Shahadat
Publisher: name: Taylor & Francis
Year: 2019

description: The vertical alignment optimization problem for road design aims to generate a vertical alignment of a new road with a minimum cost, while satisfying safety and design constraints. A new model called multi-haul quasi network flow (MH-QNF) for vertical alignment optimization is presented with the goal of improving the accuracy and reliability of previous mixed integer linear programming models. The performance of the new model is compared with two state-of-the-art models in the field: the complete transportation graph (CTG) and the quasi network flow (QNF) models. The numerical results show that, within a 1% relative error, the proposed model is robust and solves more than 93% of test problems compared to 82% for the CTG and none for the QNF. Moreover, the MH-QNF model solves the problems approximately eight times faster than the CTG model.
title: Plastics waste management and prevention of marine litter in a circular economy: push and pull instruments to enhance the use of recyclates
title: Plastics waste management and prevention of marine litter in a circular economy
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2016
Subjects: subject: waste management
subject: plastics waste
subject: plastics
subject: Abfall | Ressourcen
subject: Waste | Resources

description: The European Commission plans a common strategy for plastics in its Action Plan for the Circular Economy. This strategy for plastics is going to address marine litter as one priority issue, with three-quarters of all marine litter being plastic materials. To prevent marine litter as well as to enhance plastics waste management in a circular economy, the plastics strategy needs to put forward a fine-adjusted common policy-mixture. The policy mixture needs to include concrete and binding instruments to efficiently strengthen recycling and recyclate use in Europe. Quelle: https://www.umweltbundesamt.de
description: The European Commission plans a common strategy for plastics in its Action Plan for the Circular Economy. This strategy for plastics is going to address marine litter as one priority issue, with three-quarters of all marine litter being plastic materials. To prevent marine litter as well as to enhance plastics waste management in a circular economy, the plastics strategy needs to put forward a fine-adjusted common policy-mixture. The policy mixture needs to include concrete and binding instruments to efficiently strengthen recycling and recyclate use in Europe.
La fonction de l'art chez Platon : un instrument au service de l'État.
Creators: name: Laroche, Philippe.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Fine Arts.

description: Il y a une certaine ambivalence, dans les écrits de Platon, au sujet de l'art. D'une part, le philosophe se montre très sévère envers les artistes, voyant en eux des virtuoses de l'apparence, étrangers au savoir et inutiles à tout point de vue. Le philosophe se montre toutefois, dans certains textes, très favorable à l'art, au point même de lui confier une grande partie de l'éducation des gardiens 1 . Comment expliquer cette ambiguïté de Platon devant les beaux-arts? Cette ambiguïté peut être réduite si l'on considère la fonction de l'art dans la Cité: l'art est, chez Platon, un instrument au service de l'État. Ce que Platon condamne n'est pas que l'art soit incapable d'atteindre la vérité, mais qu'il puisse servir à transmettre des opinions et des habitudes contraires au Bien de l'État. En épurant l'art de son contenu nocif, il devient toutefois possible, pour le législateur, d'utiliser l'art à des fins éducatives: l'art sert à créer, chez les jeunes, de bonnes habitudes intellectuelles et affectives.
Simulation of reactive components by the TLM method.
Creators: name: Yue, Yuan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Engineering, Electronics and Electrical.

description: Several new models for the simulation of nonlinear components have been developed in this thesis. Firstly, the model of the stub terminated with a constant capacitance is established. Simulations of a lumped capacitance connected to a transmission line, as well as modelling of relative permittivity can be done by this approach. Secondly, the algorithm for the modelling of voltage-dependent capacitance is developed based on the model of the stub terminated with variable capacitance. Thirdly, a configuration for the simulation of series capacitance in the TLM mesh is derived. The scattering matrix and the transmission formula for the structure are developed. The structure can also be used to simulate series-connected varactor diodes. Finally, the simulation of a varactor diode is performed in the three-dimensional expanded-node scheme. In order to show the application of different models, some examples, simulation results and discussions are given in this thesis.
Analysis of partial differential equations with time-periodic forcing, applications to Navier-Stokes equations
Creators: name: Coros, Corina Alexandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Mathematics.

description: Flows with time-periodic forcing can be found in various applications, such as the circulatory and respiratory systems, or industrial mixers. In this thesis, we address few questions in relation with the time-periodic forcing of flows and related partial differential equations (PDE), including the linear Advection-Diffusion equation. In Chapter 2, we first study linear PDE's with non-symmetric operators subject to time-periodic forcing. We prove that they have a unique time-periodic solution which is stable and attracts any initial solution if the bilinear form associated to the operator is coercive, and we obtain an error estimate for finite element method with a backward Euler time-stepping scheme. That general theory is applied to the Advection-Diffusion equation and the Stokes problem. The first equation has a non-symmetric operator, while the second has a symmetric operator but two unknowns, the velocity and pressure. To apply the general theory, we prove an error estimate for a Riesz projection operator, using a special Aubin-Nistche argument for the Advection-Diffusion equation with a tune-dependent advective velocity. A spectral analysis for the 1-D Advection-Diffusion equation, relevant parameters that control the speed of convergence of any initial solution to the time-periodic solution are identified. In Chapter 3, we extend a theorem of J.L. Lions about the existence of time-periodic solutions of Navier-Stokes equations under periodic distributed forcing with homogeneous Dirichlet boundary conditions to the case of non-homogeneous time-periodic Dirichlet boundary conditions. Our theorem predicts the existence of a time-periodic solution for Navier-Stokes equations subject to time-periodic forcing but the stability of these time-periodic solutions is not known. In Chapter 4, we investigate the stability of these time-periodic solutions, through numerical simulations with test cases in a 2-D time-periodic lid driven cavity and a 2-D constricted channel with a time-periodic inflow. From our numerical simulations, it seems that a bifurcation occurs in the range 3000--8000 in the periodically driven cavity, and the range 400--1200 in the periodically driven channel.
The adoption of asynchronous online courses by professors at Memorial University of Newfoundland: A case study
Creators: name: Reid, Scott
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Education, Technology of.
subject: Education, Higher.

description: This study examined the experiences of university professors at one university as they adopted and used online courses. It drew on various theories of change to analyze the adoption of online courses by professors. Qualitative methods, involving semi-structured interviews with 32 university professors, were used to gather information about the various factors influencing university professors' adoption of online courses. Three levels of analysis---societal, institutional, and individual---were used to organize the qualitative data. The findings provide insight into the adoption experiences of professors at this university and also the future development of this new technology for teaching. These insights expand understanding of this new teaching medium for professors, university administrators, and researchers undertaking work in this area. Avenues for further research are also identified.
PTF10iya: a short-lived, luminous flare from the nuclear region of a star-forming galaxy
Creators: name: Cenko, S. Bradley
name: Bloom, Joshua S.
name: Kulkarni, S. R.
name: Strubbe, Linda E.
name: Miller, Adam A.
name: Butler, Nathaniel R.
name: Quimby, Robert M.
name: Gal-Yam, Avishay
name: Ofek, Eran O.
name: Quataert, Eliot
name: Bildsten, Lars
name: Poznanski, Dovi
name: Perley, Daniel A.
name: Morgan, Adam N.
name: Filippenko, Alexei V.
name: Frail, Dale A.
name: Arcavi, Iair
name: Ben-Ami, Sagi
name: Cucchiara, Antonio
name: Fassnacht, Christopher D.
name: Green, Yoav
name: Hook, Isobel M.
name: Howell, D. Andrew
name: Lagattuta, David
name: Law, Nicholas M.
name: Kasliwal, Mansi M.
name: Nugent, Peter E.
name: Silverman, Jeffrey M.
name: Sullivan, Mark
name: Tendulkar, Shriharsh P.
name: Yaron, Ofer
Publisher: name: Swinburne
Year: 2024

description: We present the discovery and characterization of PTF10iya, a short-lived (Δt≈ 10 d, with an optical decay rate of ∼0.3 mag d−1), luminous ( mag) transient source found by the Palomar Transient Factory. The ultraviolet/optical spectral energy distribution is reasonably well fitted by a blackbody with T≈ (1–2) × 104 K and peak bolometric luminosity LBB≈ (1–5) × 1044 erg s−1 (depending on the details of the extinction correction). A comparable amount of energy is radiated in the X-ray band that appears to result from a distinct physical process. The location of PTF10iya is consistent with the nucleus of a star-forming galaxy (z= 0.224 05 ± 0.000 06) to within 350 mas (99.7 per cent confidence radius), or a projected distance of less than 1.2 kpc. At first glance, these properties appear reminiscent of the characteristic ‘big blue bump’ seen in the near-ultraviolet spectra of many active galactic nuclei (AGNs). However, emission-line diagnostics of the host galaxy, along with a historical light curve extending back to 2007, show no evidence for AGN-like activity. We therefore consider whether the tidal disruption of a star by an otherwise quiescent supermassive black hole may account for our observations. Though with limited temporal information, PTF10iya appears broadly consistent with the predictions for the early ‘super-Eddington’ phase of a solar-type star being disrupted by a ∼107 M⊙ black hole. Regardless of the precise physical origin of the accreting material, the large luminosity and short duration suggest that otherwise quiescent galaxies can transition extremely rapidly to radiate near the Eddington limit; many such outbursts may have been missed by previous surveys lacking sufficient cadence.