cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Creators: name: Wang, Xin
name: Sun, Qian
name: Wang, Weiwen
name: Liu, Baohui
name: Gu, Ying
name: Chen, Liang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Fig. S1. Quantification control (QC) for scRNA-seq data. A–C Violin plots for the number of genes (A), number of counts (B), and percentage of mitochondrial genes (C) in each sample after QC. D–F t-SNE plots labeled by sample (D), cluster (E), and malignant status inferred by inferCNV (F).
Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina
Creators: name: Mitasova, H.
name: Berkowitz, S.
name: Kotlarz, N.
name: de los Reyes, F.L., III
name: Guidry, V.T.
name: Engel, L.S.
name: Hoppin, J.A.
name: Reckling, S.
name: Harris, A.
name: Bailey, E.
name: Daly, S.
name: Palani, S.
name: Lai, Y.-C.
name: Christensen, A.
name: Holcomb, D.A.
name: Kays, J.
name: Tanvir Pasha, A.B.M.
Publisher: name: American Public Health Association Inc.
Year: 2023

description: Objectives. To compare 4 COVID-19 surveillance metrics in a major metropolitan area. Methods. We analyzed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater influent and primary solids in Raleigh, North Carolina, from April 10 through December 13, 2020. We compared wastewater results with lab-confirmed COVID-19 cases and syndromic COVID-like illness (CLI) cases to answer 3 questions: (1) Did they correlate? (2) What was the temporal alignment of the different surveillance systems? (3) Did periods of significant change (i.e., trends) align? Results. In the Raleigh sewershed, wastewater influent, wastewater primary solids, lab-confirmed cases, and CLI were strongly or moderately correlated. Trends in lab-confirmed cases and wastewater influent were observed earlier, followed by CLI and, lastly, wastewater primary solids. All 4 metrics showed sustained increases in COVID-19 in June, July, and November 2020 and sustained decreases in August and September 2020. Conclusions. In a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab-confirmed case, and syndromic case surveillance of COVID-19 were in general agreement.
Predictors of cannabis use disorder among people living with chronic pain that use cannabis: A protocol for a systematic review and meta-analysis of observational studies
Creators: name: De Luca, Christopher
name: Foroutan, Farid
name: Darzi, Andrea
name: Busse, Jason
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Cannabis use for therapeutic purposes among those living with chronic pain is becoming more common. As an alternative to traditional opioid use, which often comes with dangers of addiction, overdose, and death in longterm uses, physicians have promoted cannabis use due its absence of such dangers. However, cannabis use could lead to cannabis use disorder (CUD). Few studies have looked into the prevalence of CUD among cannabis users but currently, there is no in-depth review of the predictive factors associated with developing CUD. Our aim is to conduct a systematic review and meta-analysis of observational studies to establish prognostic factors associated with the development of CUD among people living with chronic pain that use cannabis for treatment.
Observational Study of the Development of Diabetic Macular Edema Following Panretinal (Scatter) Photocoagulation Given in 1 or 4 Sittings
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To compare the effects of single-sitting vs. four-sitting panretinal photocoagulation (PRP) on macular edema in subjects with severe non-proliferative or early proliferative diabetic retinopathy with relatively good visual acuity and no or mild center involved macular edema.
Association of Retinal Vascular Endothelial Growth Factor With Avascular Retina in a Rat Model of Retinopathy of Prematurity
Creators: name: Budd, Steven J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To determine the effect of oxygen fluctuations on the expression of vascular endothelial growth factor (VEGF) and VEGF receptor 1(R1) and VEGFR2 using a rat model of retinopathy of prematurity (ROP).
Immunohistochemical localization of matrixmetalloproteinase-2 in human coronal dentin
Creators: name: Boushell, Lee W.
name: Yamauchi, Mitsuo
name: Kaku, Masaru
name: Bagnell, Robert
name: Mochida, Yoshiyuki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: While it is known that matrixmetalloproteinase-2 (MMP-2) is present in dentin, its distribution and role in human dentin formation and pathology are not well understood.
Risk of longer-term neurological conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort Study – Five years of follow-up
Creators: name: Rusiecki, J.A.
name: Buchanich, J.M.
name: Miller, R.G.
name: Talbott, E.O.
name: Thomas, D.L.
name: Cook, G.A.
name: Denic-Roberts, H.
name: Engel, L.S.
name: Costacou, T.
Publisher: name: BioMed Central Ltd
Year: 2023

description: Background: Long-term neurological health risks associated with oil spill cleanup exposures are largely unknown. We aimed to investigate risks of longer-term neurological conditions among U.S. Coast Guard (USCG) responders to the 2010 Deepwater Horizon (DWH) oil spill. Methods: We used data from active duty members of the DWH Oil Spill Coast Guard Cohort Study (N=45224). Self-reported oil spill exposures were ascertained from post-deployment surveys. Incident neurological outcomes were classified using International Classification of Diseases, 9th Revision, codes from military health encounter records up to 5.5 years post-DWH. We used Cox Proportional Hazards regression to calculate adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for various incident neurological diagnoses (2010–2015). Oil spill responder (n=5964) vs. non-responder (n= 39260) comparisons were adjusted for age, sex, and race, while within-responder comparisons were additionally adjusted for smoking. Results: Compared to those not responding to the spill, spill responders had reduced risks for headache (aHR=0.84, 95% CI: 0.74-0.96), syncope and collapse (aHR=0.74, 95% CI: 0.56-0.97), and disturbance of skin sensation (aHR=0.81, 95% CI: 0.68-0.96). Responders reporting ever (n=1068) vs. never (n=2424) crude oil inhalation exposure were at increased risk for several individual and grouped outcomes related to headaches and migraines (aHR range: 1.39-1.83). Crude oil inhalation exposure was also associated with elevated risks for an inflammatory nerve condition, mononeuritis of upper limb and mononeuritis multiplex (aHR=1.71, 95% CI: 1.04-2.83), and tinnitus (aHR=1.91, 95% CI: 1.23-2.96), a condition defined by ringing in one or both ears. Risk estimates for those neurological conditions were higher in magnitude among responders reporting exposure to both crude oil and oil dispersants than among those reporting crude oil only. Conclusion: In this large study of active duty USCG responders to the DWH disaster, self-reported spill cleanup exposures were associated with elevated risks for longer-term neurological conditions.
Additional file 2 of Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Creators: name: Wang, Xin
name: Sun, Qian
name: Wang, Weiwen
name: Liu, Baohui
name: Gu, Ying
name: Chen, Liang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Fig. S2. rGBM GS genes are upregulated in GBM cells at recurrence. A Scatter plot showing the DEGs of pGBM and rGBM cells compared with astrocytes respectively. B Bar plot showing the enriched GO terms (biological processes) for DEGs from Fig. S2A. The color corresponds to Fig. S2A. C Bar plots showing the expression of rGBM GS genes in primary and recurrent samples. D Scatter plot showing the regulatory activity score for deduced TFs activated in GBM cells from primary samples by RABIT [36]. E Venn diagram showing the intersection of deduced TFs by scRNA-seq data and differential motifs from scATAC-seq data [15]. F Overall survival curves of glioma patients stratified by MAFK expression using GlioVis [27].
Pressure and Phase Equilibria in Interacting Active Brownian Spheres
Creators: name: Solon, A. P.
name: Stenhammar, J.
name: Wittkowski, R.
name: Kardar, M.
name: Kafri, Y.
name: Cates, M. E.
name: Tailleur, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We derive from first principles the mechanical pressure $P$, defined as the force per unit area on a bounding wall, in a system of spherical, overdamped, active Brownian particles at density $ρ$. Our exact result relates $P$, in closed form, to bulk correlators and shows that (i) $P(ρ)$ is a state function, independent of the particle-wall interaction; (ii) interactions contribute two terms to $P$, one encoding the slow-down that drives motility-induced phase separation, and the other a direct contribution well known for passive systems; (iii) $P(ρ)$ is equal in coexisting phases. We discuss the consequences of these results for the motility-induced phase separation of active Brownian particles, and show that the densities at coexistence do not satisfy a Maxwell construction on $P$.
description: 6p (main text) + 4p (SI)
Patterns of genetic variation in European plant species depend on altitude
Creators: name: Reisch, Christoph
name: Rosbakh, Sergey
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: AFLP, alpine plant species, Alps, genetic differentiation, genetic diversity, mountain plant, topography
subject: 580 Pflanzen (Botanik)

description: Aim: High mountain regions exhibit a much stronger environmental heterogeneity and a more complex glacial history than lowland regions. In this study, we compared the genetic variation of plant species occurring in different altitudinal zones. We tested the assumption that environmental and historic differences among high mountain regions and lowlands result in different patterns of genetic diversity and differentiation. Location: Central Europe and the European Alps. Methods: We first compiled a data set on genetic variation of 179 plant species occurring in Central Europe and the European Alps measured by AFLPs from the literature. Then, we compared genetic diversity and differentiation between species occurring in the lowland, montane, subalpine and alpine vegetation zone with the help of linear models. Geographic distance among sampled populations, plant frequency and three plant traits (life span, mating system and pollination mode) were included into the models, to account for their potential effects on level of genetic variation. Results: Our analysis revealed different patterns of genetic variation in plant species occurring in the alpine and non‐alpine zone. Genetic differentiation was significantly higher among populations of species from the alpine than subalpine, montane or lowland zone. In contrast, genetic diversity was significantly lower within populations from the alpine zone compared to the other zones. Main conclusions: We argue that the observed pattern of genetic variation most likely results from restricted gene flow, both past and present, among spatially and environmentally isolated populations in alpine habitats.
Identification and characterization of neural crest-derived cells in adult periodontal ligament of mice
Creators: name: Mishina, Yuji
name: Mochida, Yoshiyuki
name: Komatsu, Yoshihiro
name: Yamauchi, Mitsuo
name: Kaku, Masaru
name: Ko, Ching-Chang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Cells derived from the neural crest (NC) contribute to the development of several adult tissues, including tooth and periodontal tissue. Here, two transgenic lines, Wnt1-Cre/ZEG and P0-Cre/ZEGwere analyzed to determine the fate and distribution of neural crest cells (NCCs) in adult mouse periodontal ligament (PDL).
California dreaming: Tech media giants and the re-conception of property, commodities and tax
Creators: name: Graham, Ciara
name: SILKE, HENRY
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 47
subject: Language, communication and culture

description: Tech media giants are no strangers to controversy in relation to the payment of corporate tax, such as the cases of Apple and Facebook (Meta) in Ireland, Alphabet (Google) in the UK and Amazon in Luxembourg. While the tech media giants are not the only global corporations that take advantage of international tax avoidance opportunities, this paper argues that their hypermobility and unprecedented cash assets place them especially well to take advantage of these practices. Moreover, the nature of some of the commodities, such as information, software or intellectual property that can be moved at the touch of a button; or even a simple re-conception of where the property resides can mean a state gaining or losing billions of dollars. This paper will explore how tech media giants are redefining property and commodity forms and how this allows for creative tax policies. Moreover, the conception of where immaterial commodities, such as pure information, is located (or not located) challenges tax collection strategies for the state. To explore these conceptions, this paper discusses the ideology surrounding the tech media industry, a particular brand of liberalism coined the ‘Californian Ideology’: An ideology that can sometimes be described as transgressive, but also one that may legitimise tax avoidance. The ideology gives a somewhat nebulous definition of what property is (and isn’t) and its location or non-location, thereby negating justification for taxation.
Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay
Creators: name: Gakhar, Lokesh
name: Guthmiller, Janet M.
name: Brogden, Kim A.
name: Bartlett, Jennifer A.
name: Johnson, Georgia K.
name: McCray, Paul B.
name: Burnell, Kindra K.
name: Kohlgraf, Karl G.
name: Joly, Sophie A.
name: Srikantha, Rupasree N.
name: Ackermann, Abbey R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The short palate lung and nasal epithelial clone 1 (SPLUNC1) protein may be differentially expressed in oral infections, oral inflammatory disorders, or oral malignancies and may be involved in innate immune responses in the oral cavity. However, the actual concentration of SPLUNC1 in saliva has not previously been determined. In this study, we determined the concentrations of SPLUNC1 in saliva using a particle-based antibody capture and detection immunoassay. A commercial goat anti-rhSPLUNC1 polyclonal antibody (AF1897) was linked to fluorescent polystyrene microspheres and used as the capture antibody. A commercial mouse IgG2b anti-rhSPLUNC1 monoclonal antibody (MAB1897) was biotinylated and used as the detection antibody. Western blot and 2-dimensional fluorescence difference gel electrophoresis (2-D DIGE) analysis of immunoprecipitated rhSPLUNC1 and SPLUNC1 from saliva were used to show that the capture AF1897 and detection MAB1897 antibodies both recognized SPLUNC1. Protein concentrations in saliva from 20 subjects ranged from 0.9 to 23.9 mg/ml; SPLUNC1 concentrations ranged from 34.7 ng/ml to 13.8 μg/ml; and SPLUNC concentrations normalized per mg of total salivary protein ranged from 4.7 ng/ml to 5.3 μg/ml. These results show that SPLUNC1 is detected in saliva in a variety of concentrations. This immunoassay may prove to be useful in determining the concentration of SPLUNC1 in saliva for assessing its role in the pathogenesis of oral infections, oral inflammatory disorders, or oral malignancies.
Additional file 3 of Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Creators: name: Wang, Xin
name: Sun, Qian
name: Wang, Weiwen
name: Liu, Baohui
name: Gu, Ying
name: Chen, Liang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3. Fig. S3. Subpopulations for GBM cells across the longitudinal samples. A t-SNE plot showing the sample type origins of GBM cells (i.e., primary and recurrent samples). B t-SNE of GBM cell subpopulations split by primary and recurrent samples. C and D t-SNE plots labeled by sample (C) and patient (D). E Heatmap showing the expression of top 50 DEGs for each GBM cell subpopulations. F and G Bar plots showing the enriched GO terms of DEGs in GBM cell subpopulations, including C1 (F) and C4 (G). H and I t-SNE plot showing the expression scores of TNF pathway (H) and AP1 family (I) in GBM cell subpopulations. (J) Dot plot showing the expression of the known diagnostic markers across GBM cell subpopulations.
Exposure patterns among coast guard responders to the Deepwater Horizon Oil Spill: A latent class analysis
Creators: name: Denic-Roberts, H.
name: Rusiecki, J.A.
name: Gribble, M.O.
name: Engel, L.S.
name: Keshav, T.
Publisher: name: Wolters Kluwer Health
Year: 2022

description: Background: The Deepwater Horizon Oil Spill was an environmental crisis for which multiple groups, including the United States Coast Guard (USCG), provided emergency response services. A cohort of 5,665 USCG oil spill responders completed postdeployment surveys eliciting information on a variety of topics, including oil spill-related exposures and experiences. Our objective was to determine the most common exposure patterns among USCG responders. Methods: We used latent class analysis based on six indicator variables reflecting different aspects of the responders' experiences: exposure to oil, exposure to engine exhaust fumes or carbon monoxide, hand sanitizer use, sunblock use, mosquito bites, and level of anxiety. We validated our interpretation of these latent classes using ancillary variables. Results: The model distinguished four distinct exposure profiles, which we interpreted as "low overall exposure" (prevalence estimate = 0.18), "low crude oil/exhaust and moderate time outdoors/anxiety (prevalence estimate = 0.18), "high crude oil/exhaust and moderate time outdoors/anxiety" (prevalence estimate = 0.25), and "high overall exposure" (prevalence estimate = 0.38). The validation analysis was consistent with our interpretation of the latent classes. Conclusions: The exposure patterns identified in this analysis can help inform future studies of the health impacts of exposure mixtures among USCG oil spill responders.
Validation of Interobserver Agreement in Lung Cancer Assessment: Hematoxylin-Eosin Diagnostic Reproducibility for Non–Small Cell Lung Cancer: The 2004 World Health Organization Classification and Therapeutically Relevant Subsets
Creators: name: Nance, Keith V.
name: Travis, William D.
name: Leslie, Kevin O.
name: Christensen, Rebecca
name: Hayes, D. Neil
name: Allen, Timothy Craig
name: Banks, Peter M.
name: Cabanski, Christopher R.
name: Qaqish, Bahjat F.
name: Wilkerson, Matthew D.
name: Jones, Kirk D.
name: Yin, Xiaoying
name: Hart, Craig F.
name: Miller, C. Ryan
name: Grilley-Olson, Juneko E.
name: Beasley, Mary B.
name: Graziano, Paolo
name: Socinski, Mark A.
name: Deblois, Georgean G.
name: Cagle, Philip T.
name: Thorne, Leigh B.
name: Moore, Dominic T.
name: Maia, Diane M.
name: Funkhouser, William K.
name: Colby, Thomas V.
name: Hayward, Michele C.
name: Elmberger, Göran
name: Stinchcombe, Thomas E.
name: Borczuk, Alain C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Precise subtype diagnosis of non–small cell lung carcinoma is increasingly relevant, based on the availability of subtype-specific therapies, such as bevacizumab and pemetrexed, and based on the subtype-specific prevalence of activating epidermal growth factor receptor mutations.
Metacognition and knowledge application: an empirical study in product design education
Creators: name: Zhang, Yang
Publisher: name: Figshare
Year: 2019
Subjects: subject: 120399 Design Practice and Management not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: The relationship between creativity and knowledge has been a debated topic in creativity and design research. Current studies have made a great effort to emphasise the significance to creativity of a specific type of knowledge, e.g. domain-specific/general, rather than interpreting their application, i.e. how they are used. That is, there is still a lack of studies to investigate the ways in which knowledge and skills within or across domains are actually used, since Christiaans and Venselaar (2005) have claimed. The lack of a performance-based measurement of creativity probably renders it difficult to ascertain whether a specific knowledge item is related to a specific creative performance. Moreover, the methodologies applied by current studies to design knowledge and creativity were based on qualitative approaches drawn from data collected from a single school in one country, ignoring the importance of the cultural context.
This thesis is supported by an investigation of a creativity-relevant construct that connects to knowledge application within the context of Product Design Education. The principal creativity-relevant construct is identified as metacognition: this identification was achieved by conducting a literature survey focusing on creativity research, which is linked to creative thinking, according to current understanding of applied knowledge, and is thought to predict creative performance. Different kinds of knowledge applied in product design students’ final-year design projects (FYDPs) have been assembled and arranged into three categories. An empirical study was conducted in the form of a survey to examine the relationship between metacognition and the frequency of applying each kind of knowledge in the process of the FYDP. Cultural factors were also considered in this study based on 375 samples collected from China (228 samples) and the UK (147 samples), representing Western and Eastern cultures.
The findings identified the shared and different frequencies of applying subject-related knowledge among students with different levels of creative thinking ability. The thesis proposes five aspects of subject-related knowledge, including product-oriented, reflection-facilitating, socio-cultural environment related, conceptual-process related, and cross-disciplinary knowledge. The data indicates that product-oriented, reflection-facilitating, and socio-cultural environment related knowledge are frequently applied by students who reported higher metacognition scores. The main contribution to knowledge made through this thesis is towards design education research, where these findings may inform and extend academic support for design tutors and students to improve the FYDP process and offer further insights into China’s design education.
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Properties of the Higgs boson with mass near 125 GeV are measured in proton-proton collisions with the CMS experiment at the LHC. Comprehensive sets of production and decay measurements are combined. The decay channels include gamma gamma, ZZ, WW, tau tau, bb, and mu mu pairs. The data samples were collected in 2011 and 2012 and correspond to integrated luminosities of up to 5.1 inverse femtobarns at 7 TeV and up to 19.7 inverse femtobarns at 8 TeV. From the high-resolution gamma gamma and ZZ channels, the mass of the Higgs boson is determined to be 125.02 +0.26 -0.27 (stat) +0.14 -0.15 (syst) GeV. For this mass value, the event yields obtained in the different analyses tagging specific decay channels and production mechanisms are consistent with those expected for the standard model Higgs boson. The combined best-fit signal relative to the standard model expectation is 1.00 +/- 0.09 (stat) +0.08 -0.07 (theo) +/- 0.07 (syst) at the measured mass. The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays. No significant deviations are found.
description: Replaced with published version. Added journal reference and DOI
Additional file 2 of Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study
Creators: name: Yamashita, Takahiro
name: Obara, Taku
name: Yonezawa, Yudai
name: Takahashi, Ippei
name: Ishikuro, Mami
name: Murakami, Keiko
name: Ueno, Fumihiko
name: Noda, Aoi
name: Onuma, Tomomi
name: Iwama, Noriyuki
name: Hamada, Hirotaka
name: Sugawara, Junichi
name: Suzuki, Shigenori
name: Suganuma, Hiroyuki
name: Saito, Masatoshi
name: Yaegashi, Nobuo
name: Kuriyama, Shinichi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 2.
Additional file 4 of Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Creators: name: Wang, Xin
name: Sun, Qian
name: Wang, Weiwen
name: Liu, Baohui
name: Gu, Ying
name: Chen, Liang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Fig. S4. Expression of signatures depicts the characteristic of GBM cell subpopulations. A t-SNE feature plot showing the expression of genes from P and GS signatures. B SNE showing the expression of genes from Ivy anatomic features. C and D Spatial transcriptomic images showing the expression scores of C7 DEGs (C) and CancerSEA signatures (D) across ST samples. C7 cells increased in rGBM and concentrated in a niche with highly ECM, MVP, angiogenesis, EMT, and invasion scores.
Objectively Measured Physical Activity in Sixth-Grade Girls
Creators: name: Sallis, James F.
name: Welk, Gregory
name: Pratt, Charlotte
name: Young, Deborah R.
name: Pate, Russell R.
name: Schmitz, Kathryn H.
name: Webber, Larry S.
name: Stevens, June
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Objectives: To describe the objectively measured physical activity characteristics of a diverse sample of sixth-grade girls, to examine influences on physical activity, and to report compliance with physical activity guidelines. Design: Cross-sectional study. Setting: Six locations across the United States. Participants: A total of 1578 sixth-grade girls. Accelerometers were worn for 7 days, and data for 6 days were included in the analyses. Main Exposures: Race/ethnicity, free or reduced-price lunch, and geographic region. Main Outcome Measures: Six operational definitions of adequate activity (60 or 30 minutes of daily moderate to vigorous physical activity at or above 4.6, 3.8, or 3.0 metabolic equivalents) were used to examine whether girls met physical activity guidelines. Results: Average times spent in sedentary, light, moderate, and vigorous activities were 460, 342, 18, and 6 min/d, respectively. White girls were more active than girls in other race/ethnic groups, and girls who did not receive free or reduced-price lunch were more active than girls who did. Girls in western states were most active. Percentages of girls in compliance with the 6 thresholds for adequate activity varied widely and ranged from 0.6% to 100.0%. Conclusions: When physical activity is measured objectively and a 4.6-metabolic equivalents cut point for moderate to vigorous physical activity is used, most sixth-grade girls do not meet guidelines for adequate physical activity. One notable finding was the effect of different accelerometer scoring protocols on estimates of compliance. Conceptual and empirical work is needed to define appropriate physical activity for youth using objective physical activity measures.
Estimation of Aerosol Concentrations of Oil Dispersants COREXIT™ EC9527A and EC9500A during the Deepwater Horizon Oil Spill Response and Clean-up Operations
Creators: name: Pratt, G.C.
name: Stenzel, M.R.
name: Ramachandran, G.
name: Arnold, S.
name: Stewart, P.A.
name: Kwok, R.K.
name: Engel, L.S.
name: Sandler, D.P.
Publisher: name: Oxford University Press
Year: 2022

description: The April 2010 Deepwater Horizon drilling unit explosion at the Macondo oil well resulted in the release of approximately 779 million l of oil into the Gulf of Mexico. As part of the response effort to break up oil slicks on the water's surface, 6.81 million l of chemical dispersants COREXIT™ EC9500A and COREXIT™ EC9527A were applied by plane or vessel or injected near the seabed. The GuLF Long-term Follow-up Study is investigating possible adverse health effects of workers involved in the oil spill response and clean-up (OSRC). In this paper, we describe potential dispersant-related air concentrations generated from aerial spraying of dispersants to provide insight as to what concentrations OSRC workers may have been exposed under worst-case conditions. Personal exposure measurement data were not collected. Modeling, therefore, was conducted to estimate airborne concentrations of total aerosol to COREXIT™ EC9527A and EC9500A. Using the AgDISP model, we estimated air concentrations to dispersant total aerosols, defined as all components of the dispersant including active ingredients, surfactants, and water, resulting from aerial and vessel applications, as average 1-h and 2-min concentrations. For comparison, 1-h air concentrations associated with aerial spraying were estimated using another model, AERMOD. At 152 m horizontal to the flight path, average 1-h total aerosol concentrations associated with aerial applications were estimated to be as high as 49.3 μg m-3 (9527A) and 45.4 μg m-3 (9500A), and both decreased with increased distance from the flight line. The estimates for spraying 9500A from vessels indicated that total aerosol concentrations were potentially as high as 0.33 μg m-3 at 10 m from the nozzles. These results suggest that personal exposures to dispersant aerosols were negligible.
title: La fiscalité de l'immobilier en question (Débats du LIEPP, n°4)
Creators: name: Wasmer, Etienne
name: Antonin, Céline
name: Touze, Vincent
name: Taly, Michel
name: Coloos, Bernard
name: Ellickson, Robert
name: Trannoy, Alain
Publisher: name: Sciences Po - LIEPP
Year: 2017
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Cette table ronde consacrée à la fiscalité de l’immobilier tombe à pic, car elle se tient le lende-main de l’annonce d’Emmanuel Macron sur France Inter de son intention de « réformer en profondeur » l’ISF et en particulier de supprimer de l’assiette « la part qui finance l'économie réelle » c’est-à-dire les actions et obligations (la part mobilière) et de transformer l’ISF en « impôt sur la rente immobilière ". Or, ce débat est ancien : les travaux de Thomas Pi-ketty ont notamment montré que le patrimoine des Français a augmenté relativement à la production nationale. Les travaux que nous avions mené avec Odran Bonnet, Guillaume Chapelle et Pierre-Henri Bono ont souligné qu’il s’agissait essentiellement de la conséquence de la hausse des prix de l’immobilier ; cf. notamment le graphique 1 et 2 ; plus récemment, des travaux ont montré que c’était même essentiellement liés à la part de la terre.
Topological anomalies for Seifert 3-manifolds
Creators: name: Imbimbo, Camillo
name: Rosa, Dario
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study globally supersymmetric 3d gauge theories on curved manifolds by describing the coupling of 3d topological gauge theories, with both Yang-Mills and Chern-Simons terms in the action, to background topological gravity. In our approach the Seifert condition for manifolds supporting global supersymmetry is elegantly deduced from the topological gravity BRST transformations. A cohomological characterization of the geometrical moduli which affect the partition function is obtained. In the Seifert context Chern-Simons topological (framing) anomaly is BRST trivial. We compute explicitly the corresponding local Wess-Zumino functional. As an application, we obtain the dependence on the Seifert moduli of the partition function of 3d supersymmetric gauge theory on the squashed sphere by solving the anomalous topological Ward identities, in a regularization independent way and without the need of evaluating any functional determinant.
description: 31 pages; v2: some comments added, references added; v3: published version, 1+34 pages, one appendix explaining the relation with the supergravity approach added, minor comments and two references added
Estimation of Dermal Exposure to Oil Spill Response and Clean-up Workers after the Deepwater Horizon Disaster
Creators: name: Engel, L.S.
name: Blair, A.
name: Jones, A.
name: Cherrie, J.W.
name: Stenzel, M.R.
name: Ng, M.G.
name: Stewart, P.A.
name: Sandler, D.P.
name: Kwok, R.K.
Publisher: name: Oxford University Press
Year: 2022

description: The GuLF STUDY is investigating health outcomes associated with oil spill-related chemical exposures among workers involved in the spill response and clean-up following the Deepwater Horizon disaster. Due to the lack of dermal exposure measurements, we estimated dermal exposures using a deterministic model, which we customized from a previously published model. Workers provided information on the frequency of contact with oil, tar, chemical dispersants applied to the oil spill and sea water, as well as the use of protective equipment, by job/activity/task. Professional judgment by industrial hygienists served as a source of information for other model variables. The model estimated dermal exposures to total hydrocarbons (THC), benzene, ethylbenzene, toluene, xylene, n-hexane (BTEX-H), polycyclic aromatic hydrocarbons (PAHs), and dispersants in GuLF DREAM units (GDUs). Arithmetic means (AMs) of THC exposure estimates across study participants ranged from <0.02 to 5.50 GDUs for oil and <0.02 to 142.14 GDUs for tar. Statistical differences in the estimates were observed among the AMs of the estimates for some broad groups of worker activities over time and for some time periods across the broad groups of activities. N-Hexane had ranges similar to THC for oil exposures (e.g. AMs up to 2.22 GDUs) but not for tar (up to 5.56 GDUs). Benzene, ethylbenzene, toluene, and xylene, in contrast, were characterized by higher exposure levels than THC for oil (AMs up to 12.77, 12.17, 17.45, and 36.77 GDUs, respectively) but lower levels than THC to tar (AMs up to 3.69, 11.65, 42.37, and 88.18 GDUs, respectively). For PAHs, the AMs were as high as 219.31 and 587.98 for oil and tar, respectively. Correlations of these seven substances to each other were high (>0.9) for most of the substances in oil but were lower for some of the substances in tar. These data were linked to the study participants to allow investigation of adverse health effects that may be related to dermal exposures.
Optimal modeling of 1D azimuth correlations in the context of Bayesian inference
Creators: name: De Kock, Michiel B.
name: Eggers, Hans C.
name: Trainor, Thomas A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Analysis and interpretation of spectrum and correlation data from high-energy nuclear collisions is currently controversial because two opposing physics narratives derive contradictory implications from the same data---one narrative claiming collision dynamics is dominated by dijet production and projectile-nucleon fragmentation, the other claiming collision dynamics is dominated by a dense, flowing QCD medium. Opposing interpretations seem to be supported by alternative data models, and current model-comparison schemes are unable to distinguish between them. There is clearly need for a convincing new methodology to break the deadlock. In this study we introduce Bayesian Inference (BI) methods applied to angular correlation data as a basis to evaluate competing data models. For simplicity the data considered are projections of 2D angular correlations onto 1D azimuth from three centrality classes of 200 GeV AuAu collisions. We consider several data models typical of current model choices, including Fourier series (FS) and a Gaussian plus various combinations of individual cosine components. We evaluate model performance with BI methods and with power-spectrum (PS) analysis. We find that the FS-only model is rejected in all cases by Bayesian analysis which always prefers a Gaussian. A cylindrical quadrupole cos(2ϕ) is required in some cases but rejected for 0-5%-central AuAu collisions. Given a Gaussian centered at the azimuth origin "higher harmonics" cos(mϕ) for m > 2 are rejected. A model consisting of Gaussian + dipole cos(ϕ) + quadrupole cos(2ϕ) provides good 1D data descriptions in all cases.
description: 24 pages, 24 figures
Novel electrosynthetic methods: focus on carbon dioxide utilisation
Creators: name: Vlod Tabas
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: Uncategorized
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The release of CO2 into the earth's atmosphere has been increasing exponentially since the dawn of the industrial age. Mainly due to the burning of fossil fuels; needed for power generation this increased amount of CO2 has been a direct cause to the increased greenhouse effect which in turn brings about severe consequences. Various ways of limiting the release CO2 have been developed over the years, with varying degrees of efficiency and success. Carbon Dioxide utilisation (CDU) is a relatively new technique which utilises CO2 rather than storing it. The main challenges associated with this technique stem from a sustainability aspect, therefore research is placed into developing methods which are environmentally friendly as well as energy and cost efficient. Many research groups from around the world have developed various techniques and approaches to incorporate CO2 into a variety of organics ranging from haloalkanes to alkynes. These techniques have ranged from using standard chemical reactions, intricate photocatalysts to using electrochemical processes, all with the main goal of forming a stable C-C bond, however all these methods possess some form of shortcomings. This project addresses the shortcomings in electrochemical methods associated with CO2. The discovery of a novel electrochemical process using non-sacrificial carbon electrodes in the hydrocarboxylation of styrenes was achieved under mild conditions, (10 Volts, 1 atm CO2 pressure, room temperature, non-sacrificial electrodes) was achieved producing the corresponding mono-carboxylic acids in a highly regioselective manner in good to excellent yields (50-85%). The novel method also proved successful in incorporating CO2 in alkynes, dienes, and acrylates as well as the reducing of internal double bonds. Furthermore, mechanistic analysis was undertaken to deduce the mode of action, this included the use of deuterium labelled reagents, cyclopropyl traps as well as common radical traps. This work has shown the potential of non-sacrificial electrochemical cells, by-passing the environmental and efficiency issues attributed with common electrochemical cells. The bonus of high regioselectivity, robustness towards various functional groups and potential to apply to various starting materials further enhances the potential of this method in become a valuable tool in organic synthesis.
Travel by Walking Before and After School and Physical Activity Among Adolescent Girls
Creators: name: Strikmiller, Patty
name: Catellier, Diane J.
name: Going, Scott
name: Saksvig, Brit I.
name: Treuth, Margarita S.
name: Pfeiffer, Karin
name: Conway, Terry
name: Ward, Dianne
name: Schmitz, Kathryn H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: To examine how travel by walking before and after school contributes to total physical activity of adolescent girls.
ANECA_CoARA Action Plan_2024-2027
Creators: name: Blanco Palencia, María
name: Paneque Salgado, Pilar
name: Ramos Vielba, Irene
Publisher: name: Zenodo
Year: 2024
Subjects: ANECA
CoARA
Action Plan

description: This Action Plan of ANECA (National Agency for Quality Assessment and Accreditation of Spain) is defined within the CoARA framework for the period 2024-2027, and foresees the development of 18 actions organised around 6 action lines. This 2024-2027 Action Plan is a first proposal for internal and external activities to advance the reform and thus improve the assessment of scientific production in line with the CoARA commitments.
Additional file 1 of Protocol: a simple method for biosensor visualization of bacterial quorum sensing and quorum quenching interaction on Medicago roots
Creators: name: Rosier, Amanda
name: Bais, Harsh P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1: Figure S1. Spectinomycin resistant bacteria tests of the KYC55 biosensor. Left plate: top row is Rm8530-spec, bottom row is Rm8530-spec with UD1022 ycbU. Right plate: top row is Rm8530-spec, middle row is Rm8530-spec with 100 µg ml-1 YtnP, bottom row is Rm8530-spec with 100 µg ml-1 heat killed YtnP.
Higher derivative Chern-Simons extension in the noncommutative QED$_{3}$
Creators: name: Ghasemkhani, M.
name: Bufalo, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The noncommutative (NC) massive quantum electrodynamics in $2+1$ dimensions is considered. We show explicitly that the one-loop effective action arising from the integrating out the fermionic fields leads to the ordinary NC Chern-Simons and NC Maxwell action at the long wavelength limit (large fermion mass). In the next to leading order, the higher-derivative contributions to NC Chern-Simons are obtained. Moreover, the gauge invariance of the outcome action is carefully discussed. We then consider the higher-derivative modification into the pure NC Chern-Simons Lagrangian density and evaluate the one-loop correction to the pole of the photon propagator.
description: 20 pages, published version
Linear Relationships Between Total Hydrocarbons and Benzene, Toluene, Ethylbenzene, Xylene, and n-Hexane during the Deepwater Horizon Response and Clean-up
Creators: name: Stewart, P.A.
name: Ramachandran, G.
name: Quick, H.
name: Banerjee, S.
name: Sandler, D.P.
name: Groth, C.P.
name: Huynh, T.B.
name: Engel, L.S.
name: Stenzel, M.R.
name: Blair, A.
name: Kwok, R.K.
Publisher: name: Oxford University Press
Year: 2022

description: Objectives: Our objectives were to (i) determine correlations between measurements of THC and of BTEX-H, (ii) apply these linear relationships to predict BTEX-H from measured THC, (iii) use these correlations as informative priors in Bayesian analyses to estimate exposures. Methods: We used a Bayesian left-censored bivariate framework for all 3 objectives. First, we modeled the relationships (i.e. correlations) between THC and each BTEX-H chemical for various overarching groups of measurements using linear regression to determine if correlations derived from linear relationships differed by various exposure determinants. We then used the same linear regression relationships to predict (or impute) BTEX-H measurements from THC when only THC measurements were available. Finally, we used the same linear relationships as priors for the final exposure models that used real and predicted data to develop exposure estimate statistics for each individual exposure group. Results: Correlations between measurements of THC and each of the BTEX-H chemicals (n = 120 for each of BTEX, 36 for n-hexane) differed substantially by area of the Gulf of Mexico and by time period that reflected different oil-spill related exposure opportunities. The correlations generally exceeded 0.5. Use of regression relationships to impute missing data resulted in the addition of >23 000 n-hexane and 541 observations for each of BTEX. The relationships were then used as priors for the calculation of exposure statistics while accounting for censored measurement data. Conclusions: Taking advantage of observed relationships between THC and BTEX-H allowed us to develop robust exposure estimates where a large amount of data were missing, strengthening our exposure estimation process for the epidemiologic study.
Additional file 2 of Protocol: a simple method for biosensor visualization of bacterial quorum sensing and quorum quenching interaction on Medicago roots
Creators: name: Rosier, Amanda
name: Bais, Harsh P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2: Figure S2. Six day after germination (DAG) M. truncatula seedlings do not QQ oxo-C16 AHL. Left plate: top row is Rm8530 alone, bottom row is 10 µM oxo-C16 AHL alone. Right plate: M. truncatula with 10 µM oxo-C16 AHL.
Obesity in the Transition to Adulthood: Predictions Across Race/Ethnicity, Immigrant Generation, and Sex
Creators: name: Perreira, Krista M.
name: Harris, Kathleen Mullan
name: Lee, Dohoon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: With longitudinal data we traced how race, ethnic, and immigrant disparities in body mass index (BMI) change over time as adolescents (ages 11–19) transition to young adulthood (ages 20–28).
Short-term Change in Body Mass Index in Overweight Adolescents Following Cholesterol Screening
Creators: name: Perrin, Eliana M.
name: Lazorick, Suzanne
name: Esserman, Denise
name: Steiner, Michael J.
name: Doshi, Nipa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To determine the relationship between routine screening for cholesterol level and subsequent change in body mass index (BMI; calculated as weight in kilograms divided by height in meters squared).