cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The pharmacology of novel illicit synthetic cannabinoids
Creators: name: Stuart, Jordyn M.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Herbal smoking mixtures containing illicit synthetic cannabinoids (SCs), originally sold as legal substitutes to cannabis, have become the most rapidly growing class of recreational designer drugs since 2008. Legal restrictions on the first generation SCs created a chemist-driven structural evolution making identification and the study of their pharmacology and toxicology difficult. The consumption of these novel compounds is of major concern as the toxicity seems to be increasing with each new generation of structures. As very little is known about their pharmacological activity, it was pertinent to establish their actions at cannabinoid receptors CB₁ and CB₂. This was done using a high-throughput fluorescent-based plate reader membrane potential assay on AtT20 pituitary tumor cells stably transfected with either rat or human cDNA for CB₁ and human cDNA for CB₂. Relevant off target pathways, specifically the TRP channels, were also tested for activity by measuring the changes in intracellular calcium in a fluorescent-based plate reader assay on HEK293 cells transfected with human TRPA1 or human TRPV1. Approximately 60 SCs were tested and all showed activity at both CB₁ and CB₂ receptors with the majority having high efficacy and potency. Some compounds were up to 1,000 times more potent at CB₁ in comparison to Δ⁹-THC, the main psychoactive ingredient in cannabis. Many also differed from Δ⁹-THC by showing a selectivity for CB₂. The physiological implications of this outcome have yet to be determined but could play a role in toxicity. At the off target pathways only one SC showed partial agonist activity at TRPV1 but 28 showed agonist activity at TRPA1 ranging from partial to full agonists. As these ion channels have been implicated in the cardiovascular system, gastrointestinal system and CNS, their activation could be another mode of toxicity. Finally, a method was developed using reverse phase column chromatography and HPLC/MS/MS to measure endocannabinoid levels in cells lines after a drug stimulation. Preliminary data showed that SCs can affect the endocannabinoid system further proving their lack of specificity.
Additional file 1 of Financial incentives for hypertension control: rationale and study design
Creators: name: Liqiang Zheng
name: Yali Wang
name: Sitong Liu
name: Zheng, Rui
name: Dongmei Pei
name: Yingxian Sun
name: Zhaoqing Sun
Publisher: name: figshare
Year: 2020
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.
Playing with fantasy: how Diana Wynne Jones pushes back the boundaries of the genre
Creators: name: Rumbold, Margaret
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The purpose of this study is to explore the ways in which Diana Wynne Jones' fantasies represent a paradigm shift for the genre of fantasy literature written for children. I suggest that this can be observed in her employment of a number of postmodern strategies that problematise notions of reality, and in her construction of subjectivity. In order to fulfil this objective the study first establishes an appropriate critical discourse for examining her fantasies and concludes that they can best be understood in a postmodern framework. A representative selection of her texts is then discussed in the light of a number of postmodern characteristics. In order to examine Jones' approach to subjectivity the study then goes on to establish a set of features that characterise the construction of subjectivity in children's fantasy. I then demonstrate the way in which the construction of subjectivity in her texts has changed from representing subjectivity as a homogeneous construct to a heterogeneous construct, thus creating a paradigm shift for the genre. The study concludes by examining the one area in which her fantasies still largely conform with traditional characteristics of the genre-that of gender.
How do men permanently remove erectile problems?
Creators: name: Priscila, Priscila de Sousa Martins
Publisher: name: Zenodo
Year: 2024

description: Men facing erectile problems often seek permanent solutions to regain their sexual confidence and overall well-being. While there are various methods and treatments available, it's essential to approach the issue with a holistic mindset. Here are some effective ways for men to permanently address erectile problems:

1. Healthy Lifestyle Changes: Incorporating regular exercise, a balanced diet, and adequate sleep can significantly improve erectile function. Exercise helps improve blood flow, which is crucial for achieving and maintaining an erection.

2. Stress Management: Chronic stress can contribute to erectile problems. Learning stress-reducing techniques such as meditation, deep breathing exercises, or engaging in hobbies can help manage stress levels and improve sexual function.

3. Medical Intervention: Consulting with a healthcare professional is crucial to address any underlying medical conditions contributing to erectile problems. They can recommend treatments such as medication, hormone therapy, or surgery if necessary. Try Vidalista tablets to cure erectile problems in men.

4. Counseling or Therapy: Erectile problems can often have psychological roots. Seeking counseling or therapy can help address any emotional or mental barriers that may be affecting sexual performance.

5. Quitting Unhealthy Habits: Smoking, excessive alcohol consumption, and substance abuse can all contribute to erectile problems. Quitting these habits can have a positive impact on sexual function.

6. Communication and Support: Open communication with a partner about erectile problems can alleviate stress and improve intimacy. Seeking support from loved ones or joining support groups can also provide emotional support during the journey to overcoming erectile issues.

By taking a comprehensive approach that addresses physical, emotional, and lifestyle factors, men can work towards permanently resolving erectile problems and reclaiming their sexual vitality. It's important to remember that seeking professional guidance and support is key to finding the most effective and personalized solution.
Uncover Your Genetic Identity with Face DNA Testing
Creators: name: Jamiee
name: Russell
Publisher: name: Zenodo
Year: 2024

description: In the realm of DNA testing, advancements are continually expanding the horizons of what we can learn about ourselves. Face DNA testing, a revolutionary technology offered at Face DNA Test, brings a unique approach to uncovering your genetic identity.

Unlocking the Secrets of Your DNA through Facial Recognition

Face DNA testing takes the science of DNA analysis to a whole new level by incorporating facial recognition technology. This innovative approach allows individuals to gain insights into their genetic makeup by simply uploading a photo of their face to our secure online platform. Our advanced algorithms analyze facial features and genetic markers to provide personalized genetic reports with remarkable accuracy.

A Window into Your Ancestry and Genetic Traits

Curious about your ancestry? Wondering about inherited traits or predispositions? Face DNA testing can provide answers. Our comprehensive reports delve into various aspects of your genetic profile, including ancestry composition, ethnic origins, and genetic traits. Discover your roots, uncover hidden family connections, and gain valuable insights into your genetic predispositions with FaceDNATest.com.

Empowering Personalized Health and Wellness

Understanding your genetic makeup can also empower you to take proactive steps towards better health and wellness. Our reports highlight genetic traits related to nutrition, fitness, and health conditions, enabling you to make informed lifestyle choices tailored to your unique genetic profile. Whether it's optimizing your diet, personalizing your fitness routine, or managing potential health risks, Face DNA testing equips you with the knowledge you need to live your healthiest life.

Confidentiality and Security You Can Trust

At FaceDNATest.com, we prioritize the confidentiality and security of your genetic data. Our platform utilizes industry-leading encryption protocols to safeguard your information, ensuring that your privacy is protected every step of the way. You can trust us to handle your genetic data with the utmost care and professionalism.

Experience the Future of DNA Testing with FaceDNATest.com

Ready to embark on a journey of self-discovery through face DNA testing? Visit FaceDNATest.com today to learn more about our cutting-edge technology and how it can help you uncover the secrets hidden within your DNA. Take the first step towards unlocking the mysteries of your genetic identity and embrace a future where knowledge is power.
A data placement approach for scientific workflow execution in hybrid clouds
Creators: name: Pasdar, Amirmohammad
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Cloud computing has been widely adopted by industry practitioners and researchers. Recently, applications in science and engineering such as scientific workflows have also been increasingly deployed in clouds. As these applications are becoming resource intensive in both data and computing, private clouds struggle to cope with their resource requirements. Public clouds claim to overcome many shortcomings of private clouds. However, the complete offloading of workflow execution to public clouds may introduce excessive data transfer and privacy/governance concerns. In this thesis, we propose a hybrid cloud solution for workflow scheduling explicitly considering data placement. To this end, we present Hybrid Scheduling for Hybrid Clouds (HSHC), which schedules scientific workflows across private and public clouds incorporating a novel dynamic data placement policy. HSHC consists of two phases: static and dynamic. The former uses an extended genetic algorithm to solve the problem of workflow scheduling with static information of workflows and cloud resources. The latter adjusts scheduling and data placement decisions reflecting changing conditions of workflow execution in the hybrid cloud. We evaluate HSHC with both real-world scientific applications and random workflows in performance and cost. Experimental results demonstrate HSHC’s two-phase approach effectively deals with the dynamic nature of the hybrid cloud.
Enhance Your Truck's Performance with Top-Quality Repair Services in Fort Worth
Creators: name: Jamiee
Publisher: name: Zenodo
Year: 2024

description: 1. Comprehensive Truck Repair Solutions

When it comes to keeping your truck running smoothly, trust BS Truck Repair  for comprehensive solutions tailored to your needs. Our expert technicians specialize in a range of services, from pinpointing engine issues with advanced diagnostics to ensuring your brakes are in top condition for safe travels. Whether it's transmission troubles or issues with your suspension and steering, we've got you covered with thorough and effective repairs.

2. State-of-the-Art Facility and Equipment

At BSTruckRepair.com, we invest in the latest tools and equipment to deliver top-notch service for your truck. Our state-of-the-art facility is equipped with cutting-edge diagnostic tools, allowing us to quickly and accurately identify any issues your truck may be experiencing. Plus, we only use high-quality parts and materials to ensure lasting results and maximum performance for your vehicle.

3. Dedicated Expertise and Experience

Our team of skilled technicians at BSTruckRepair.com brings years of experience and specialized knowledge to every repair job. Whether you drive a light-duty pickup or a heavy-duty commercial truck, we have the expertise to handle repairs for various makes and models. You can trust us to diagnose and resolve any issue with precision and efficiency, getting you back on the road with confidence.

4. Prompt and Efficient Service

We understand that time is of the essence when it comes to truck repairs. That's why we pride ourselves on providing prompt and efficient service at BSTruckRepair.com. Our goal is to minimize downtime for your truck and get you back on the road as quickly as possible. With fast turnaround times and attention to detail, you can rely on us to deliver the results you need, when you need them.

5. Customer-Centric Approach

At BSTruckRepair.com, customer satisfaction is our top priority. We believe in transparent communication and strive to keep you informed throughout the repair process. Our friendly and helpful staff is always available to answer any questions you may have and ensure your experience with us is seamless and stress-free. When you choose BSTruckRepair.com, you can expect personalized service and a commitment to exceeding your expectations.

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Ready to experience the difference with BSTruckRepair.com? Schedule an appointment with us today to get your truck the quality repair and maintenance it deserves. Whether you need routine maintenance or major repairs, we're here to help. Learn more about our services and how we can keep your truck running smoothly for miles to come.
Transverse linear and orbital angular momenta of beam waves and propagation in random media
Creators: name: Charnotskii, Mikhail
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: For paraxial propagation of scalar waves the classic electromagnetic theory definition of transverse linear (TLM) and orbital angular (OAM) momenta of the beam wave are represented in terms of the coherence function. We show in examples that neither the presence of optical vortices is necessary for the intrinsic OAM, nor does the presence of optical vortices warrant the non-zero intrinsic OAM. The OAM is analyzed for homogeneously coherent and twisted partially coherent beam waves. A twisted Gaussian beam has an intrinsic OAM with a per-unit power value that can be continuously changed by varying the twist parameters. Using the parabolic propagation equation for the coherence function, we show that both total TLM and OAM are conserved for the free-space propagation, but not for propagation in an inhomogeneous medium. In the presence of the random inhomogeneous medium, the total TLM and OAM are conserved in average, but the OAM fluctuations grow with the propagation path. This growth is slower for beams with rotation-symmetric irradiance.
description: Submitted to JOSA A May 12, 2017
SpeedyPaper.com: Your Destination for Tailored Coursework Writing and Expert Essay Assistance
Creators: name: Speedy
Publisher: name: Zenodo
Year: 2024

description: SpeedyPaper.com has solidified its position as a reliable and reputable platform in the academic writing industry. With a focus on delivering quality, maintaining affordability, and ensuring customer satisfaction, SpeedyPaper.com has garnered trust and loyalty from students globally.

A standout offering from SpeedyPaper.com is its coursework writing service. Recognizing the unique challenges students face in their academic pursuits, SpeedyPaper.com offers specialized coursework writing solutions tailored to meet individual needs. Whether students are grappling with intricate topics, juggling tight deadlines, or aiming to improve the quality of their coursework, SpeedyPaper.com's coursework writing service delivers personalized and effective solutions. For those keen to explore this service in detail, they can click Speedy Paper site to uncover the comprehensive offerings and advantages.

Alongside its coursework writing service, SpeedyPaper.com also provides expert academic essay help. Mastery of essay writing is pivotal for academic success, requiring clarity, persuasive argumentation, and adherence to academic standards. Acknowledging the hurdles students face in this domain, SpeedyPaper.com extends its expertise to offer comprehensive essay help, guiding students through each step of the writing process.

With SpeedyPaper.com's academic essay help, students can expect essays that are well-researched, well-structured, and free from plagiarism and grammatical errors. The dedicated team of writers at SpeedyPaper.com excels at crafting compelling essays that resonate with readers and meet academic standards. Whether students require assistance with topic selection, research, writing, or editing, SpeedyPaper.com's academic essay help service offers personalized support to propel them toward academic excellence.

SpeedyPaper.com's commitment to excellence is further demonstrated by its customer-centric approach. Understanding the diverse backgrounds and unique needs of students, SpeedyPaper.com strives to make its services accessible and affordable without compromising on quality. Whether students are clicking Speedy Paper site to explore coursework writing services or seeking expert essay help, SpeedyPaper.com consistently upholds high standards of quality and professionalism in every assignment.

In conclusion, SpeedyPaper.com serves as a trusted and dependable platform offering specialized coursework writing services and expert essay help to students worldwide. Whether students are facing challenges with coursework writing, navigating the intricacies of essay writing, or tackling any other academic assignment, SpeedyPaper.com possesses the expertise, resources, and commitment to assist them in achieving academic success. With its proficient team of writers, dedication to quality, and customer-focused approach, SpeedyPaper.com remains the preferred choice for students striving to enhance their academic performance and confidently achieve their academic goals.
MobilizeThis 2010: Five Years On Five Years Back
Creators: name: Hayes, Alexander
Publisher: name: figshare
Year: 2017
Subjects: subject: Art
subject: 130202 Curriculum and Pedagogy Theory and Development
subject: FOS: Educational sciences
subject: Digital Humanities
subject: 130303 Education Assessment and Evaluation
subject: 130306 Educational Technology and Computing

description: A comprehensive presentation of all things Mobilizethis from over the research years.
Development of a smart sensing system for early detection of osteoporosis
Creators: name: Afsarimanesh, Nasrin
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Early detection of any disease is essential for an efficient treatment. Bone loss can be detected and monitored by regular measurement of serum or urine C-terminal telopeptide of type 1 collagen (CTx-I). Therefore, rapid, sensitive, accurate, portable and low-cost point-of-care devices are highly desirable. In this research, we have proposed a selective, sensitive, quick and inexpensive Internet of Things (IoT)-based device for the quantification of CTx-I levels in serum. A capacitive interdigital sensor with multi-sensing electrode configuration was employed to perform the experiments. Initially, natural antibodies were used to introduce selectivity for the target molecule. In spite of the high selectivity and sensitivity of the proposed system, there were some limitations in using natural antibodies. Natural antibodies are very expensive, sensitive to harsh environmental conditions and have limited stability. In order to overcome these limitations, the interdigital sensor was coated with artificial antibodies, prepared by molecular imprinting technology. Electrochemical impedance spectroscopy was used to evaluate the resistive and capacitive properties of the sample solutions. A microcontroller-based system was developed for the measurement of the level of CTx-I in serum and for data transmission to an IoT-based cloud server. The data can be provided to the medical practitioner and a detailed investigation can start for early detection and treatment. The developed sensing system responded linearly in a range of 0.1 ppb to 2.5 ppb, which covers the normal reference range of CTx-I in serum, with a limit of detection (LOD) of 0.09 ppb. The results demonstrated that the proposed portable biosensing system could provide a rapid, simple and selective approach for CTxI measurement in serum. Sheep serum samples were tested using the proposed system and the validation of the results was done using an enzyme-linked immunosorbent assay (ELISA) kit.
Memahami Prinsip Utmost Good Faith dalam Asuransi
Creators: name: Reliance Life, Reliance Life
Publisher: name: Zenodo
Year: 2023
Subjects: Reliance life

description: Asuransi merupakan salah satu instrumen keuangan yang memiliki peran vital dalam melindungi kekayaan dan keamanan finansial seseorang atau perusahaan. Dalam ranah asuransi, terdapat sebuah prinsip yang sangat mendasar, yaitu Utmost Good Faith atau Kepercayaan Mutlak. 

Dalam artikel ini, kita akan membahas dengan mendalam mengenai prinsip ini dan bagaimana penerapannya dalam dunia asuransi.

Apa itu Utmost Good Faith?

Utmost Good Faith adalah prinsip dasar yang mengharuskan semua pihak yang terlibat dalam kontrak asuransi untuk bertindak dengan itikad baik dan jujur. Pihak-pihak ini termasuk pemegang polis (asuradur) dan perusahaan asuransi (penanggung). 

Prinsip ini membentuk dasar etika dalam dunia asuransi, di mana setiap informasi yang relevan dan penting harus disampaikan dengan jujur oleh kedua belah pihak.

Baca Selengkapnya di : https://reliance-life.co.id/
Study of $Υ(nS)$ ${\to}$ $B_{c}P$ decays with perturbative QCD approach
Creators: name: Yang, Yueling
name: Sun, Junfeng
name: Guo, Yan
name: Li, Qingxia
name: Huang, Jinshu
name: Chang, Qin
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: With the potential prospects of the $Υ(nS)$ at high-luminosity dedicated heavy-flavor factories, the color-favored $Υ(nS)$ ${\to}$ $B_{c}π$, $B_{c}K$ weak decays are studied with the pQCD approach. It is found that branching ratios for the $Υ(nS)$ ${\to}$ $B_{c}π$ decay are as large as the order of ${\cal O}(10^{-11})$, which might be measured promisingly by the future experiments.
description: 14 pages, 2 figures. arXiv admin note: substantial text overlap with arXiv:1610.06986
Building skills and toolkits for the research data interviews : learnings from the Monash University Library Research Data Collections Project
Creators: name: Todd, Paula
name: Waylen, Jacqueline
name: McCulloch, Julie
Publisher: name: Monash University
Year: 2017
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Poster presented at eResearch Australasia, 2010
Small steps to building research data management capability: the Monash University Library Research Data Collections Project.
Creators: name: Todd, Paula
name: Waylen, Jacqueline
name: Brown, Kerry
Publisher: name: Monash University
Year: 2017
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Poster presented by Paula Todd, Jacqueline Waylen and Kerry Murphy at eResearch Australasia, 2011.
Mixed-effects models for health care longitudinal data with an informative visiting process: A Monte Carlo simulation study.
Creators: name: Gasparini, Alessandro
name: Abrams, Keith R
name: Barrett, Jessica K
name: Major, Rupert W
name: Sweeting, Michael J
name: Brunskill, Nigel J
name: Crowther, Michael J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Longitudinal data
Monte Carlo simulation
Selection Bias
Electronic Health Records
Mixed‐effects Models
Informative Visiting Process
Inverse Intensity Of Visiting Weighting
Recurrent‐events Models

description: Electronic health records are being increasingly used in medical research to answer more relevant and detailed clinical questions; however, they pose new and significant methodological challenges. For instance, observation times are likely correlated with the underlying disease severity: Patients with worse conditions utilise health care more and may have worse biomarker values recorded. Traditional methods for analysing longitudinal data assume independence between observation times and disease severity; yet, with health care data, such assumptions unlikely hold. Through Monte Carlo simulation, we compare different analytical approaches proposed to account for an informative visiting process to assess whether they lead to unbiased results. Furthermore, we formalise a joint model for the observation process and the longitudinal outcome within an extended joint modelling framework. We illustrate our results using data from a pragmatic trial on enhanced care for individuals with chronic kidney disease, and we introduce user-friendly software that can be used to fit the joint model for the observation process and a longitudinal outcome.
The technological innovation capabilities in Asian latecomers: patenting evidence from the solar photovoltaic industries of Taiwan, Korea, and China
Creators: name: Wu, Ching-Yan
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This Thesis builds on work previously undertaken by scholars in industries such as semiconductors and flat panel displays to investigate innovation performance and knowledge flows as these industries diffuse from advanced countries (US, Japan and Europe) to catch-up follower countries (Taiwan, Korea and China). The aim is to investigate the emergent solar photovoltaic industry by updating and applying the arguments developed in the earlier studies. The solar photovoltaic industry is of particular interest in that its exploitation is poised between first generation crystalline silicon technologies and the newer technologies based on thin films and organic compounds. This study is distinctive in that it exploits two patent datasets for solar PV technologies, from the US Patent and Trademark Office and from the Europe Patent Office; it approaches these datasets in two stages, singling out three generations of technology and four technology platforms underpinning the evolving knowledge flows and innovative technological capabilities of the solar photovoltaic industry in the Asian latecomers. A set of stylized facts is identified and used to frame the research contribution of this Thesis. The main results demonstrate that the knowledge sources for building innovation capabilities in the three latecomer countries are gradually shifting from a principal reliance on exogenous technological forerunners (US, Japan et al.) towards a greater dependence on indigenous knowledge and internalization capability, while accommodating to diverse national innovation systems. This illustrates the latecomers’ transition and transformation from imitators to innovators in the setting of the global solar photovoltaic industry. Clear policy implications for other latecomer countries and future research are also elaborated.
Crumble Junkbot - Eggbot
Creators: name: Turner, Scott
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: Turner, S. J. (2017) Junkbots - Crumble eggbot. Workshop presented to: Mozilla Festival, Ravensbourne College, London, 27-29 October 2017
Turning drinks cans, motors, tape; along with Crumble controller into simple slightly controllable bots. Add pens makes them draw (put lines on the paper) under program control.
Additional file 12: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment
Creators: name: Xu, Wanfu
name: Qian, Jiabi
name: Zeng, Fangyin
name: Li, Songyu
name: Guo, Wenjing
name: Chen, Liping
name: Li, Guihuan
name: Zhang, Zhishuai
name: Wang, Qiming
name: Deng, Fan
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Figure S10. Effect of PKD inhibitor on body weight change in vivo. (PDF 514 kb)
No-hair theorems for a static and stationary reflecting star
Creators: name: Bhattacharjee, Srijit
name: Sarkar, Sudipta
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We prove the non existence of massive scalar, vector and tensor hairs outside the surface of a static and stationary compact reflecting star. Our result is the extension of the no hair theorem for black holes to horizonless compact configurations with reflecting boundary condition at the surface. We also generalize the proof for spacetimes with a positive cosmological constant.
description: Typos corrected. New references added. Accepted for publication in Phys. Rev. D
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Creators: name: Waldron, Joseph A
name: Tack, David C
name: Ritchey, Laura E
name: Gillen, Sarah L
name: Wilczynska, Ania
name: Turro, Ernest
name: Bevilacqua, Philip C
name: Assmann, Sarah M
name: Bushell, Martin
name: Le Quesne, John
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Translation
Cancer
RNA structure
Translation initiation
DMS
G-quadruplexes
Eif4a
Polysome Profiling
Hippuristanol
Structure-seq

description: Funder: Medical Research Council
description: BACKGROUND:The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus understanding how this protein leads to the selective re-programming of the translational landscape is critical. While it is known that eIF4A1-dependent mRNAs frequently have long GC-rich 5'UTRs, the details of how 5'UTR structure is resculptured by eIF4A1 to enhance the translation of specific mRNAs are unknown. RESULTS:Using Structure-seq2 and polysome profiling, we assess global mRNA structure and translational efficiency in MCF7 cells, with and without eIF4A inhibition with hippuristanol. We find that eIF4A inhibition does not lead to global increases in 5'UTR structure, but rather it leads to 5'UTR remodeling, with localized gains and losses of structure. The degree of these localized structural changes is associated with 5'UTR length, meaning that eIF4A-dependent mRNAs have greater localized gains of structure due to their increased 5'UTR length. However, it is not solely increased localized structure that causes eIF4A-dependency but the position of the structured regions, as these structured elements are located predominantly at the 3' end of the 5'UTR. CONCLUSIONS:By measuring changes in RNA structure following eIF4A inhibition, we show that eIF4A remodels local 5'UTR structures. The location of these structural elements ultimately determines the dependency on eIF4A, with increased structure just upstream of the CDS being the major limiting factor in translation, which is overcome by eIF4A activity.
Discover Your Health from Head to Toe with Full Body Scans in Dallas
Creators: name: Jamiee
name: Russell
Publisher: name: Zenodo
Year: 2024

description: In the bustling city of Dallas, staying on top of your health is essential for living life to the fullest. At 123BodyScan, we offer state-of-the-art full body scanning services that provide comprehensive insights into your overall health and wellness.

A Comprehensive Approach to Health Monitoring

Gone are the days of relying solely on sporadic check-ups to assess your health. With full body scans at 123BodyScan, you can gain a holistic view of your body's condition from head to toe. Our advanced imaging technology captures detailed images of your internal organs, bones, and tissues, allowing our medical professionals to detect potential health issues at their earliest stages.

Early Detection Saves Lives

Early detection is key when it comes to managing and treating various health conditions. Our full body scans enable early detection of abnormalities such as tumors, cysts, and other potential health concerns that may not yet be causing symptoms. By identifying these issues early on, we can work with you and your healthcare provider to develop personalized treatment plans and interventions that can ultimately save lives.

Peace of Mind Through Proactive Health Monitoring

Maintaining optimal health isn't just about addressing existing issues; it's also about preventing future problems from arising. Our full body scans provide valuable information about your overall health status, empowering you to take proactive steps towards wellness. Whether it's adjusting your lifestyle habits, starting a new fitness regimen, or seeking further medical evaluation, our scans give you the peace of mind that comes with being proactive about your health.

State-of-the-Art Technology, Expert Analysis

123BodyScan utilizes cutting-edge imaging technology and employs experienced medical professionals to ensure the highest level of accuracy and precision in our scans. Our team of radiologists and healthcare professionals meticulously analyze the scan results, providing detailed reports and recommendations tailored to your individual health needs.

Your Health, Our Priority

At 123BodyScan, your health is our top priority. We understand that each individual is unique, which is why we take a personalized approach to every scan we perform. Whether you're seeking a baseline assessment of your health or monitoring a specific condition, our full body scans in Dallas are designed to meet your needs and exceed your expectations.

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Ready to take control of your health and wellness journey? Schedule your full body scan at 123BodyScan today. Our convenient location in Dallas, coupled with our commitment to excellence, makes us the premier choice for comprehensive health monitoring in the area. Don't wait until it's too late – invest in your health and well-being with 123BodyScan.
MOESM1 of A balanced game: chicken macrophage response to ALV-J infection
Creators: name: Feng, Min
name: Xie, Tingting
name: Li, Yuanfang
name: Zhang, Nan
name: Lu, Qiuyuan
name: Zhou, Yaohong
name: Shi, Meiqing
name: Sun, Jingchen
name: Zhang, Xiquan
Publisher: name: figshare
Year: 2019
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. List of primers used in the study.
The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response.
Creators: name: Till, Christopher J
name: Vicente, Jorge
name: Zhang, Hongtao
name: Oszvald, Maria
name: Deery, Michael J
name: Pastor, Victoria
name: Lilley, Kathryn S
name: Ray, Rumiana V
name: Theodoulou, Frederica L
name: Holdsworth, Michael J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Priming
Proteostasis
Plant Immunity
Pipecolic Acid
N‐degron Pathway
Prt1

description: N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the N-end rule pathway) control the stability of substrate proteins dependent on the amino-terminal (Nt) residue. Unlike yeast or mammalian N-recognin E3 ligases, which each recognize several different classes of Nt residues, in Arabidopsis thaliana, N-recognin functions of different N-degron pathways are carried out independently by PROTEOLYSIS (PRT)1, PRT6, and other unknown proteins. PRT1 recognizes type 2 aromatic Nt-destabilizing residues and PRT6 recognizes type 1 basic residues. These two N-recognin functions diverged as separate proteins early in the evolution of plants, before the conquest of the land. We demonstrate that loss of PRT1 function promotes the plant immune system, as mutant prt1-1 plants showed greater apoplastic resistance than WT to infection by the bacterial hemi-biotroph Pseudomonas syringae pv tomato (Pst) DC3000. Quantitative proteomics revealed increased accumulation of proteins associated with specific components of plant defense in the prt1-1 mutant, concomitant with increased accumulation of salicylic acid. The effects of the prt1 mutation were additional to known effects of prt6 in influencing the immune system, in particular, an observed over-accumulation of pipecolic acid (Pip) in the double-mutant prt1-1 prt6-1. These results demonstrate a potential role for PRT1 in controlling aspects of the plant immune system and suggest that PRT1 limits the onset of the defense response via degradation of substrates with type 2 Nt-destabilizing residues.
Enhancement of immune response against Bordetella spp. by disrupting immunomodulation.
Creators: name: Gestal, Monica C
name: Howard, Laura K
name: Dewan, Kalyan
name: Johnson, Hannah M
name: Barbier, Mariette
name: Bryant, Clare
name: Soumana, Illiassou Hamidou
name: Rivera, Israel
name: Linz, Bodo
name: Blas-Machado, Uriel
name: Harvill, Eric T
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: Well-adapted pathogens must evade clearance by the host immune system and the study of how they do this has revealed myriad complex strategies and mechanisms. Classical bordetellae are very closely related subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them to either persist for life or repeatedly infect the same host. Exploring the hypothesis that exposure to immune cells would cause bordetellae to induce expression of important immunomodulatory mechanisms, we identified a putative regulator of an immunomodulatory pathway. The deletion of btrS in B. bronchiseptica did not affect colonization or initial growth in the respiratory tract of mice, its natural host, but did increase activation of the inflammasome pathway, and recruitment of inflammatory cells. The mutant lacking btrS recruited many more B and T cells into the lungs, where they rapidly formed highly organized and distinctive Bronchial Associated Lymphoid Tissue (BALT) not induced by any wild type Bordetella species, and a much more rapid and strong antibody response than observed with any of these species. Immunity induced by the mutant was measurably more robust in all respiratory organs, providing completely sterilizing immunity that protected against challenge infections for many months. Moreover, the mutant induced sterilizing immunity against infection with other classical bordetellae, including B. pertussis and B. parapertussis, something the current vaccines do not provide. These findings reveal profound immunomodulation by bordetellae and demonstrate that by disrupting it much more robust protective immunity can be generated, providing a pathway to greatly improve vaccines and preventive treatments against these important pathogens.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Cart. 187 (11 H 72), f. 0083v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0083v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0083v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Adaption to climate change: a case study of two agricultural systems from Kenya
Creators: name: Stefanovic, Julia Olivera
name: Yang, Hong
name: Zhou, Yuan
name: Kamali, Bahareh
name: Ogalleh, Sarah Ayeri
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: This study contributes to a better understanding of climate change adaptation by investigating different farming systems and by including cognitive factors as explanatory variables. We compared a food crop and a horticultural farming system, regarding applied adaptation measures and factors influencing adaptation. The data were based on a field survey of 267 smallholder farmers in Laikipia County of Kenya. A binary logistic regression was conducted against individual adaptation measures to identify determinants of adaptation. Adaptation measures employed by food crop farmers were mainly risk-reducing, such as mixed- and inter-cropping, planting early-maturing crop varieties and early planting. In contrast, horticultural farmers tended to focus more on intensifying crop production and applied crop rotation, irrigation and application of agro-chemicals, artificial fertilizer and manure. Factors positively influencing adaptation included access to extension services and risk perception among horticultural farmers, and access to workforce and farmers groups among food crop farmers. Furthermore, food crop farmers with access to less risk-prone income sources than agriculture seemed to have less motivation to adapt. The study showed that as climate change progresses, social differences between horticultural and food crop farmers are likely to increase, hence leading to inequalities in adaptation at local levels. Adaptation planners need to address these differences if sustainable adaptation is to be achieved.
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Creators: name: anion, femin
Publisher: name: Zenodo
Year: 2024

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Additional file 2 of Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis
Creators: name: Peng, Huan-Wen
name: Lian, Lian
name: Zhang, Jun
name: Erst, Andrey S.
name: Wang, Wei
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Fig. S1. Evolutionary inference of nutrition types for Neottieae. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral states obtained by BayesTraits. Fig. S2. Ancestral range reconstruction for Neottieae using BioGeoBEARS under the statistical DEC model. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral distributions. Areas with probabilities below 5% are hidden and lumped together in black.
Adaption to climate change: a case study of two agricultural systems from Kenya
Creators: name: Stefanovic, Julia Olivera
name: Yang, Hong
name: Zhou, Yuan
name: Kamali, Bahareh
name: Ogalleh, Sarah Ayeri
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: This study contributes to a better understanding of climate change adaptation by investigating different farming systems and by including cognitive factors as explanatory variables. We compared a food crop and a horticultural farming system, regarding applied adaptation measures and factors influencing adaptation. The data were based on a field survey of 267 smallholder farmers in Laikipia County of Kenya. A binary logistic regression was conducted against individual adaptation measures to identify determinants of adaptation. Adaptation measures employed by food crop farmers were mainly risk-reducing, such as mixed- and inter-cropping, planting early-maturing crop varieties and early planting. In contrast, horticultural farmers tended to focus more on intensifying crop production and applied crop rotation, irrigation and application of agro-chemicals, artificial fertilizer and manure. Factors positively influencing adaptation included access to extension services and risk perception among horticultural farmers, and access to workforce and farmers groups among food crop farmers. Furthermore, food crop farmers with access to less risk-prone income sources than agriculture seemed to have less motivation to adapt. The study showed that as climate change progresses, social differences between horticultural and food crop farmers are likely to increase, hence leading to inequalities in adaptation at local levels. Adaptation planners need to address these differences if sustainable adaptation is to be achieved.