cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
How Teen Mothers Participating in a Teen Mother and Child Program Narrate Their Own Identities as Mothers and Women
Creators: name: Macintosh, Janelle LaNae Bassett
Publisher: name: University of Utah
Year: 2014

description: Women undergo many changes associated with pregnancy, both biological and psychological. The focus of this study was to explore the construction of motherhood identity by teen mothers. Specifically I explored how pregnant teens narrate and perform motherhood in a Teen Mother and Child Program. Data were gathered using observation, informal and formal interviews, and field notes. Narrative analysis and the Burkean Pentad were used to analyze these data. Teens were cast a supporting cast members by the omnipresent narrator in the Teen Mother and Child Program, the certified nurse-midwives (CNM). The positioning of cast members was performed by the CNMs and not challenged by teen mothers and often supported in their position of power by the teen mothers and their support people. The star of the narrative in the clinic was the unborn child. In the personal narratives, from in-depth interviews, the teen mothers told stories of change, in three acts. The three acts are labeled, The Test, The Loss of My Body, and In My Arms. The cast members were similar but arranged in different positions of lead and supporting roles. Teen mothers cast themselves as the lead throughout the three acts of their narratives. The casting illuminated a disconnect between the clinic and the personal narratives of teen mothers. The implications to nurses and nurse-midwives abound and include the need to understand how teen mothers position themselves in the construction of their own mother identity.
Phytochemical properties of essential oil from Artemisia sieberi Besser (Iranian accession) and its antioxidant and antifungal activities
Creators: name: Ghasemi, Ghader
name: Alirezalu, Abolfazl
name: Ishkeh, Shirin Rahmanzadeh
name: Ghosta, Youbert
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: In this study, the phytochemical profile, the essential oil composition of an Iranian accession of Artemisia sieberi and their antioxidant and antifungal properties were investigated. The amount of essential oil yield was 1.5% (w/v) and twenty two components were identified by GC-MS analysis being camphor (33.64%), 1,8-cineole (25.66%) and chrysanthenone (7.86%) the major compounds. The amount of total polyphenols and flavonoids, total ascorbic acid and carotenoid content of A. sieberi extract were determined, and resulted in 666.26 mg GAE/100g DW, 54.77 mg QUE/100g DW, 153.585 mg/100g DW, and 907.18 mg/100g FW, respectively. Highest antioxidant activity based on DPPH bioassay was recorded in essential oil (84.04%) and extract (89.33%). Furthermore, the essential oil of A. sieberi tested for its antifungal activity, demonstrated to reduce significantly the mycelium growth rate of Botrytis cinerea, that is, no mycelial growth was observed at concentrations 1000 and 1500 μll−1.
Sonnenfleckenzeichnung Nr. 22595.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.08.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Musculoskeletal modeling for intrafacicular multielectrode stimulation of the feline hindlimb
Creators: name: MacFadden, Lisa Ness
Publisher: name: University of Utah
Year: 2012
Subjects: Musculoskeletal modeling
Biarticular muscles
Control
Monoarticular muscles
Neuroengineering
Neuroprosthesis
Spinal cord injury
Intrafascular multielectrode stimulation
Feline hindlimb
Utah array
IFMS

description: Spinal cord injuries result in a loss of control of the muscles and organs innervated by the nerves below the level of the injury and can have a significant impact  on the quality of life for the individuals affected. Functional electrical stimulation (FES) techniques have provided a way, via neural prosthetics, to regenerate limited control of the musculoskeletal system for persons with spinal cord injuries. Intrafascicular multielectrode stimulation (IFMS) is a form of functional electrical stimulation which utilizes penetrating electrodes such as the Utah Slanted Electrode Array. This array has 100 electrodes which are inserted into the nerve and provide selective control of muscles innervated by the peripheral nervous system. Before IFMS or FES can be used to restore muscle control for spinal cord injury patients, the muscles which are to be stimulated must be selected and stimulation paradigms must be determined. By using a  musculoskeletal model in conjunction with numerical simulations, muscle activation paradigms can be determined for a given behavior. Additionally, muscle subsets (which can be selectively stimulated instead of the full set of available muscles) can be explored  parametrically.
Sonnenfleckenzeichnung Nr. 22658.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.11.1967, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Velucarpin D, a new pterocarpan from the stems of Dalbergia velutina and its cytotoxicity
Creators: name: Kaennakam, Sutin
name: Sukandar, Edwin Risky
name: Hongnak, Siriwat
name: Rassamee, Kitiya
name: Siripong, Pongpun
name: Tip-Pyang, Santi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2–10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2, and HT-29). Compound 2 showed potent cytotoxicity against all the five human cancer cell lines with IC50 values in the range of 4.74–8.46 µM. In addition, compounds 1, 3, 4, 5 and 9 showed moderate cytotoxicity against both KB and HeLa S-3 cells with IC50 values in the range of 14.23–29.35 µM.
Sonnenfleckenzeichnung Nr. 22591.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.08.1967, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 22611.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.09.1967, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
(+)-7-O-Methylisomiroestrol, a new chromene phytoestrogen from the Pueraria candollei var. mirifica root
Creators: name: Yusakul, Gorawit
name: Juengsanguanpornsuk, Wipawee
name: Sritularak, Boonchoo
name: Phaisan, Suppalak
name: Juengwatanatrakul, Thaweesak
name: Putalun, Waraporn
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer

description: (+)-7-O-Methylisomiroestrol (MeI), a novel chromene, was discovered as a phytoestrogen in the Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (PM) root having been used as an active agent against oestrogen depletion disorders. The identification of PM phytochemicals is crucial for the development of standardised botanical drugs of PM. MeI was purified from the root cortex of PM, and its structure was elucidated using NMR and mass spectrometry. The content of MeI in the root bark of the PM root was 2.1–6.5 × 10−3% (w/w). The oestrogenic potency of MeI was stronger than that of isomiroestrol but less than that of deoxymiroestrol and miroestrol. Therefore, MeI is a new oestrogenic biomarker for the effective chemical standardisation of the PM extract for health product development.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.10.1967, erstellt von Dursun Koçer an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728
Creators: name: Saepua, Siriporn
name: Kornsakulkarn, Jittra
name: Auncharoen, Patchanee
name: Rachtawee, Pranee
name: Kongthong, Surisa
name: Boonyuen, Nattawut
name: Harding, David J.
name: Nehira, Tatsuo
name: Thongpanchang, Tienthong
name: Thongpanchang, Chawanee
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher’s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).
Synthesis and cytotoxicity of novel 14α-O-(andrographolide-3-subsitutedisoxazole-5-carboxylate) derivatives
Creators: name: Mokenapelli, Sudhakar
name: Yerrabelli, Jayaprakash Rao
name: Das, Neeladrisingha
name: Roy, Partha
name: Chitneni, Prasad Rao
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Simple and efficient method was established for the synthesis of a new family of 14α-O-(andrographolide-3-subsitutedisoxazole-5-carboxylate) derivatives (10a-j) from naturally occurring andrographolide (1) by selective esterification with propiolic acid at C-14 using protection and deprotection strategy followed by metal free 1,3-dipolar cycloaddition with aryl nitrile oxides. All the synthesised derivatives were tested for their cytotoxicity against HCT-15, HeLa and DU145 cell lines. Most of the compounds exhibited improved cytotoxic activity compared to the parent molecule andrographolide (1), as the compounds 10b, 10c, 10i, 10j, 11d and 11f showed significant cytotoxicity against three cancer cell lines. Except the compound 10b and 11d, all the compounds did not inhibit the normal cell line (VERO). Based on these studies isoxazole ester derivatives at C-14 of andrographolide with various substitutions promoting anticancer activities and better safety profiles. Further studies in this direction with improved water solubility and oral bioavailability are in progress in future.
Antimicrobial compounds isolated from Tropaeolum tuberosum
Creators: name: Ticona, Luis Apaza
name: Sánchez, Ángel Rumbero
name: Gonzáles, Óscar Orozco
name: Doménech, Montserrat Ortega
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Activity-guided fractionations of black tubers of Tropaeolum tuberosum led to the isolation of 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl] benzonitrile (1) and [3,5-Bis (1,1-dimethylethyl)-4-hydroxyphenyl] ethenylidene] bis-phosphonic acid tetraethyl ester (2). Compounds 1 and 2 showed an antibacterial effect against almost all the strains assayed, especially compound 2, showing the same inhibition potential for Enterococcus faecalis and Salmonella enteritidis as the ampicillin (MIC = 1.5 μM) and a better potential than chloramphenicol which has a MIC of 3.5 μM. In addition, compounds 1 and 2 showed a relevant antifungal inhibition against Candida tropicalis with MICs of 100 μM and 50 μM, and against Saccharomyces kudriavzevii with MICs of 25 μM and 1.5 μM. This is in comparison to fluconazole which had MICs of 150 μM (against Candida tropicalis) and 3.5 μM (against Saccharomyces kudriavzevii). This is the first time that compounds 1 and 2 are reported as showing antimicrobial activities.
Essential oils of Taxandria fragrans and Melaleuca alternifolia have effective antidermatophytic activities in vitro and in vivo that are antagonised by ketoconazole and potentiated in gold nanospheres
Creators: name: Carmo, Paulo H. F.
name: Costa, Marliete C.
name: Franco, Pedro H. C.
name: Lage, Anna C. P.
name: Rocha, Cláudia E. V.
name: Chaves, Claudilene R.
name: Faraco, André A. G.
name: Ladeira, Luiz O.
name: Aguilar, Jorge L. López
name: César, Isabela C.
name: Paixão, Tatiane A.
name: Resende-Stoianoff, Maria A.
name: Santos, Daniel A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: The investigation of the effects of three essential oils (EOs) from Taxandria fragrans (FRA), Melaleuca alternifolia (TTO) and Boswellia serrata (IF), alone and combined with ketoconazole (KTZ), and their functionalised gold nanoparticles (AuNP) against Trichophyton interdigitale both in vitro and in vivo indicated that EOs presented activity against T. interdigitale. The combination of EOs and KTZ was antagonistic. FRA, TTO, gold nanoparticles capped with T. fragrans (AuNPFRA) and gold nanoparticles capped with M. alternifolia (AuNPTTO) presented antidermatophytic activity in vivo, with the capacity to reduce fungal burden and to preserve tissue architecture; however, combination treatment with KTZ increased fungal burden and caused tissue damage. The combination of EO with KTZ exhibited antagonistic activity and was histologically harmful. In contrast, FRA, TTO, AuNPFRA and AuNPTTO are promising treatments for dermatophytosis.
Environmental differences in tropical soil temperatures in Kenya
Creators: name: Mace, William Davis
Publisher: name: University of Utah
Year: 2013
Subjects: Climate
Kenya
Lake Turkana
Modeling
Soil Temperature
Turkana

description: Environmental temperature differences within tropical soils are a function of the total solar radiation received at the surface, and also depend on woody vegetation cover. Environmental soil temperature is recorded by carbon isotope substitutions during the formation of calcite, which is preserved in paleosols. Therefore, analysis of preserved carbonates can be used as a proxy indicator of paleotemperatures. Preliminary data from hominid sites in the Turkana Basin show that soil temperatures have been in excess of 30°C for much of the past 4-6 million years in that region. In this study two years of continual subsurface soil monitoring were conducted at 28 sites within and around Kenyan National Parks and we present annual and seasonal averages of soil temperatures at a depth of 25 cm within different microclimates, which should approximate the absolute formation temperature of soil carbonates in present day tropical soils. In addition, we use an iterative method to solve the heat diffusion equation to estimate the soil surface temperature. In the tropics, where the solar angle is high throughout the year, observed environmental temperature differences over small spatial distances are as high as 30°C in the most extreme contrasts between grassland and forested microclimates. Average soil temperatures at 25 cm depth are highest in the Turkana basin where annual and seasonal averages are in excess of 30°C. These results are consistent with the paleotemperature measurements, indicating that temperatures are as hot today as they have been over the past several million years.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.11.1967, als Blatt eröffnet dank auswärtiger Beobachtungen, ausgewertet in Zürich, beschriftet mit: Waldmeier / Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung bzw. Auswertung aufgrund auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, erstellt durch Mitarbeitende der Eidgenössischen Sternwarte Zürich
Generalized inverse problem in electrocardiography: theoretical, computational and experimental results
Creators: name: Johnson, Christopher Ray
Publisher: name: University of Utah
Year: 2012
Subjects: Multicomponent Computer Model

description: The electrical behavior within the heart gives rise to electrostatic potentials on the body surface.  These potentials are related to potentials on the epicardial surface and are dependent on the geometry and resistive properties of the passive volume conductor between the heart and body surface.  The determination of detailed information about the heart from noninvasive electrical measurements taken on the body surface is defined as the inverse problem in electrocardiography.  In this study the generalized inverse problem in electrocardiography is solved for an anisotropic inhomogeneous volume conductor utilizing epicardial and torso potentials.  The strategy includes a multicomponent computer model which consists of 1) a finite element program to solve the electrocardiographic field equation by utilizing the Ritz technique to reformulate  the differential equation into a global  integral equation;  2)  a penalty method algorithm that is applied to the Dirichlet condition to assure accuracy at the boundaries;  and 3) a local Tikhonov regularizing algorithm,  used to  constrain  the  solution by restoring continuous dependence of the solution on the data.  This is achieved by utilizing a general discrepancy principle that makes use of measurement errors of torso potentials and discretization errors to optimize the choice of the regularization parameter.  Objectives included theoretical, computational, and experimental studies of the effectiveness of the homogeneous assumption using a realistic geometry as well as optimization of the a priori regularization parameter.  The studies were carried out using a concentric spheres model and a realistic torso model, which is the computational equivalent of an electrolytic tank.  Forward and inverse calculations were performed using both models.     It was shown that the multi-component computer model was effective for solving forward and inverse problems in anisotropic, inhomogeneous media exhibiting realistic geometry.  It was also shown that the homogeneous assumption is not valid for recovering detailed electrical information on the epicardial surface through an anisotropic,   inhomogeneous torso.  The difficulty lies, not in the new ideas, but in escaping the old ones, which ramify, for those brought up as most of us have been, into every corner of our minds.
Additional file 3 of The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers
Creators: name: Sundet, Birgitte Kordt
name: Kreyberg, Ina
name: Staff, Anne Cathrine
name: Carlsen, Karin Cecilie Lødrup
name: Bains, Karen Eline Stensby
name: Berg, Jens Petter
name: Granum, Berit
name: Haugen, Guttorm
name: Hedlin, Gunilla
name: Jonassen, Christine Monceyron
name: Nordhagen, Live Solveig
name: Nordlund, Björn
name: Rehbinder, Eva Maria
name: Rudi, Knut
name: Rueegg, Corina Silvia
name: Sjøborg, Katrine Dønvold
name: Skjerven, Håvard Ove
name: Söderhäll, Cilla
name: Vettukattil, Riyas
name: Sugulle, Meryam
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3: Table S3. Effect of nicotine exposure on midpregnancy PlGF, stratified by fetal sex.
Additional file 1 of Municipal healthcare professionals’ interprofessional collaboration during older patients’ transitions in the municipal health and care services: a qualitative study
Creators: name: Eika, Marianne
name: Hvalvik, Sigrun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 1.
Sonnenfleckenzeichnung Nr. 22642.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.10.1967, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Anti-leukemic activity of semisynthetic derivatives of lupeol
Creators: name: Machado, Vanessa Rocha
name: Jacques, Amanda Virtuoso
name: Marceli, Natália Stefanes
name: Biavatti, Maique Weber
name: Santos-Silva, Maria Cláudia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In our previous work, lupeol was isolated from aerial parts of V. scorpioides and modified by semisynthetic approach. The purpose of this study was to investigate the cytotoxicity of lupeol and its derivatives previously prepared on the human K562 acute myeloid leukemia cell and human Jurkat acute lymphoid leukemia cell in vitro. Compounds 3β-hydroxylup-20(29)-en-30-al (2), lup-20(30)-en-3β,29-diol (3), 3β-acetoxylup-20(29)-en-30-al (5) and 3β-acetoxy-30-hydroxylup-20(29)-ene (6) presented cytotoxicity with IC50 ranging from 11.72 to 56.15 µM at 24 h of incubation for both cell lines. Most of the active compounds (3, 5 and 6) were selective to leukemia cells, in compare with healthy cells. The hemolysis assay showed high blood compatibility of the cytotoxic lupeol derivatives which makes possible an intravenous administration of these compounds aiming to the potential to development of anti-leukemic drugs.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.12.1967, erstellt von Gisèle Evrard-Kesteloot, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Women's recollections regarding the initiation of oral contraceptives and their perceived importance upon compliance a descriptive study
Creators: name: Butters, Cindy
Publisher: name: University of Utah
Year: 2012
Subjects: Adverse Effects
Hormones

description: Oral contraceptives (OCs) represent one of the most popular and efficacious reversible forms of birth control available to women in the United States. However, there continues to be a high rate of discontinuation due to experiences of side effects. Most women (80%) should be able to tolerate at least one of the available OC preparations without side effects of any type. Previous studies conducted on OC discontinuation have suggested that an increase in patient education regarding side effects improves compliance. The purpose of this study was to describe women's recollections of their experience with OCs and their perceptions of the significance of education provided to them as it related to side effect severity perception and compliance. A sample of 30 women who had initiated OCs within the past 2 years at Planned Parenthood Association of Utah, located in Salt Lake City, was obtained by convenience sampling. Quantitative data were gathered using a questionnaire developed for this study. Data were analyzed using frequency distributions, t tests, and Pearson's r. Results included that side effect severity was perceived as higher if the side effect was unexpected. In addition, the unexpected side effects led to the most OC discontinuations in the sample. There was an overall low frequency of side effects discussed with the provider. Neither discussion of the side effect with the provider nor presence of a 3-month follow-up were significantly related to side effect severity perception. The educational points listed on the protocol had an extremely high recall rate and were ranked by the subjects to be mostly important to them. Implications from the data suggest that expanding the side effect patient education at initiation and follow-up to include specific side effect anticipatory guidance may reduce the unexpectedness of the side effect and thereby limit the number of discontinuations. Information gained from this study can be used to plan future research surrounding OC management.
Sonnenfleckenzeichnung Nr. 22583.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.08.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 2 of Municipal healthcare professionals’ interprofessional collaboration during older patients’ transitions in the municipal health and care services: a qualitative study
Creators: name: Eika, Marianne
name: Hvalvik, Sigrun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 2.
Transcriptional Regulation of Lipid Homeostasis in Drosophila
Creators: name: Sieber, Matthew H.
Publisher: name: University of Utah
Year: 2014

description: The ability to sense metabolic status and coordinately regulate specific aspects of metabolism is central to human health and disease. The second chapter of this dissertation defines a role for the Drosophila nuclear receptor, DHR96, as a key regulator that coordinates triacylglycerol (TAG) and cholesterol homeostasis. Studies presented in this dissertation show that DHR96 maintains whole animal TAG levels by promoting the breakdown of dietary TAG through regulation of the intestinal lipase Magro. Previous studies have shown that DHR96 binds cholesterol in its ligand-binding domain and regulates the transcriptional response to dietary cholesterol. The third chapter of this dissertation describes how, in conjunction with its role in promoting dietary TAG digestion, DHR96 functions through magro to prevent the accumulation of excess sterols in the fly. Magro exerts this role in cholesterol homeostasis through its cholesterol esterase activity, cleaving stored cholesterol esters to promote sterol excretion. Taken together, these studies define a key role for DHR96 in coordinating dietary TAG digestion and maintaining cholesterol homeostasis through its regulation of magro. Observations made during my studies of Drosophila lipid metabolism suggested that the metabolic state of the progeny is dependent on the health and nutritional status of their parents. The fourth chapter of this dissertation shows that temporary dietary restriction during the parental iv generation influences TAG and glycogen levels in the resulting progeny, as well as specific changes in metabolic gene expression. This work also defines roles for both DHR96 and HP1 as key regulators of these transgenerational effects on metabolism, suggesting that transcriptional regulation and chromatin are a central part of this pathway. Overall, these studies establish a new genetic system and framework for detailed molecular characterization of the mechanisms that facilitate the transgenerational regulation of metabolism, including an investigation of nuclear receptor and chromatin factors in this process.
The Contribution of Heme Electrostatics and Active-site Conformational Dynamics to CYP3A4-Mediated Dehydrogenation of Raloxifene and 4-Hydroxy-Tamoxifen
Creators: name: Shahrokh, Kiumars
Publisher: name: University of Utah
Year: 2014

description: The characterization of novel and reactive Phase I metabolites of xenobiotics, such as those frequently produced by P450 enzymes, is an area of interest that has led to increased research efforts during preclinical drug-testing and development. A key interest is improving our understanding of factors that contribute to competing Phase I reaction mechanisms, some of which produce stable products that can be further metabolized and excreted, and others that produce reactive metabolites capable of causing toxicities. Due to the highenergy nature of the P450 catalytic oxyferryl heme species, Compound I, P450 enzymes can also catalyze different oxidation reaction mechanisms, including dehydrogenation reactions. Dehydrogenation reactions are more difficult to predict than the more common P450 oxygenation and dealkylation reactions. Moreover, dehydrogenation mechanisms can compete with hydroxylation mechanisms to produce unstable desaturated electrophilic metabolites capable of forming potentially toxic biomolecular adducts. The work presented here focuses on improving existing computational tools for the prediction of P450 metabolism of two model substrates, raloxifene and 4-hydroxy-tamoxifen. These two compounds are FDA-approved selective estrogen receptor modulators currently used in the treatment of breast cancer. In Chapter 2 the development, iv testing and refinement of molecular mechanics parameters for key species of the heme prosthetic group during the P450 catalytic cycle is presented. It is shown that the assignment of atomic partial charges for key heme species improves the identification of the sites of metabolism of raloxifene by CYP3A4. Building on this work, in Chapter 3 it is shown that despite using these new heme parameters, extensive quantum mechanics calculations to probe substrate reactivity, molecular dynamics of the enzyme structure to find representative active site conformations makes the greatest improvement in the identification of the sites of metabolism for 4-hydroxy-tamoxifen. In summary, this work identifies that heme electrostatics and enzyme conformational dynamics play important roles in enzyme function and that the ability to predict sites of metabolism for P450- substrates requires the integration of both for the improvement of future in silico tools.
Sonnenfleckenzeichnung Nr. 22636.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.10.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Canthon (Canthon) podagricus Harold 1868
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Canthon
Canthon podagricus

description: Canthon (Canthon) podagricus Harold, 1868
Canthon podagricus Harold 1868a: 38 (Brazil)
Distribution. French Guiana: A. Schmidt 1922a: 79; Blackwelder 1944: 201 (as C. podagricum). Brazil: Harold 1868a: 38; Gillet 1911b: 32; A. Schmidt 1922a: 79; Balthasar 1939e: 214; Blackwelder 1944: 201 (as C. podagricum); Vulcano and Pereira 1964: 626; Vaz-de-Mello 2000: 191 (as C. (Canthon) podagricum). Other: A. Schmidt 1922a: 79 (Argentina); Blackwelder 1944: 201 (Argentina - as C. podagricum); Vulcano and Pereira 1964: 626 (Argentina).
Note. Canthon podagricus has only been reported for French Guiana in A. Schmidt (1922a: 79) and Blackwelder (1944: 201), with the latter likely based on the former. The absence of any other records for the research area makes us doubt the validity of this record. The presence of this species in the research area needs confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 63, DOI: 10.5281/zenodo.3678492
Geophysical signatures of volcano-hosted geothermal systems
Creators: name: Raharjo, Imam Baru
Publisher: name: University of Utah
Year: 2012
Subjects: Geothermal
Heat and fluid simulations
Magnetotellurics
Microseismic
Resistivity
Volcanoes

description: Geophysical signatures of volcano-hosted geothermal systems in Indonesia are com-piled and synthesized. Parameters include electrical resistivity, seismicity, downhole logging, and pressure/temperature data; temperature and pressure states of systems are simulated through numerical models. The systems are Sungai Penuh, Hululais, Lumutbalai, Ulubelu, Kamojang, Kotamobagu, Tompaso, and Lahendong. The general resistivity structure of the systems comprises a vertical conductor under the volcano peak (< 10 ohm.m), a lateral conductor under the volcano   ank (< 10 ohm.m), and an intermediate resistivity zone under the lateral conductor. Background formations  are generally resistive with a resistivity > 70 ohm.m. The vertical conductor is the expression of either an active or inactive volcanic neck / magmatic chimney. The lateral conductor is the claycap of the geothermal system containing an argillic alteration zone  that keeps the hot Fluids and the heat inside the reservoir. The topography of the volcano  dictates the hydrology and shapes the extent of the lateral conductor. The hydrothermal fluids themselves are kept within the intermediate resistivity region, 10-60 ohm.m for a liquid-dominated system, and up to 100 ohm.m for a vapor-dominated system, preferably  with the temperature of 200-300 °C. On the margins, the reservoir may have either sharp or diff use contact with the background or the claycap; vapor-dominated systems have a sharp contact. A di ffuse contact is usually associated with a gradational change in  temperature, with temperature reversal at depth. The caprock of a geothermal system has an aseismic character possibly due to its ductile behavior from the clay and from its low permeability structure. The low permeability property impedes liquid movement  and ashing that could induce seismicity. The propylitic reservoir is seismogenic due to less clay content and its high permeability that promotes liquid movement and   ashing into steam which induces seismicity. Modeling studies suggest that the most favorable permeability con guration for a vapor-dominated reservoir similar to Kamojang con-tains a caprock with the permeability of 3 x 10-16 m2 accompanied with a rechargeregion/hostrock having the permeability of 10-18 m2 to 10-17 m2. A heat ow of 8 MW/km2 for 9 kyr is the minimum combination to produce a thick vapor-dominated zone (> 1000 meter) in a 2.8 km thick reservoir with the permeability of 10-13 m2.  Model simulations are produced that reach steady state at 10.7 kyr, with 38-40 bar and 250-252 °C reservoir yielding a heat loss of 90 MW and 35 kg/s of steam escaping from the reservoir. This study provided an unusual opportunity to characterize and model  volcano-hosted geothermal systems.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.11.1967, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm). Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt.
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Bioassay-guided purification, GC-MS characterization and quantification of phyto-components in an antibacterial extract of Searsia lancea leaves
Creators: name: Vambe, M.
name: Naidoo, D.
name: Aremu, A. O.
name: Finnie, J. F.
name: Van Staden, J.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Phytocompounds in an aqueous methanol (70% MeOH) leaf extract of Searsia lancea were separated using liquid-liquid partitioning techniques and gravity-assisted column chromatography. The resultant fractions were screened for antibacterial properties (minimum inhibitory concentration, MIC) against four bacterial strains (Enterococcus faecalis, Klebsiella pneumoniae, Neisseria gonorrhoeae and Staphylococcus aureus). Bioactive fractions were purified using preparative thin layer chromatography (TLC) and subjected to further antibacterial screening. Phytocompounds in antibacterial sub-fractions were characterized and quantified using Gas Chromatography-Mass Spectrometry (GC-MS). An ethyl acetate sub-fraction purified from the aqueous methanol extracts of the leaves demonstrated potent antibacterial properties (MIC range: 31-61 µg/ml against E. faecalis and S. aureus). Based on GC-MS analysis, 81.5% of the sub-fraction consisted of broad-spectrum antibacterial compounds namely tetracosanol (43.98%) and nonadecanol (37.5%). Current research findings support the traditional use of S. lancea leaves to manage gastro-intestinal disorders and gonorrhoea.
The development of an aerial robotics laboratory highlighting the first experimental validation of optimal reciprocal collision avoidance
Creators: name: Conroy, Parker James
Publisher: name: University of Utah
Year: 2013
Subjects: Collision avoidance
ORCA
Quadrotor
ROS
UAV
VO

description: This thesis details the development of the Algorithmic Robotics Laboratory, its experimental software environment, and a case study featuring a novel hardware validation of optimal reciprocal collision avoidance. We constructed a robotics laboratory in both software and hardware in which to perform our experiments. This lab features a netted flying volume with motion capture and two custom quadrotors. Also, two experimental software architectures are developed for actuating both ground and aerial robots within a Linux Robot Operating System environment. The first of the frameworks is based upon a single finite state machine program which managed each aspect of the experiment. Concerns about the complexity and reconfigurability of the finite state machine prompted the development of a second framework. This final framework is a multimodal structure featuring programs which focus on these specific functions: State Estimation, Robot Drivers, Experimental Controllers, Inputs, Human Robot Interaction, and a program tailored to the specifics of the algorithm tested in the experiment. These modular frameworks were used to fulfill the mission of the Algorithmic Robotics Lab, in that they were developed to validate robotics algorithms in experiments that were previously only shown in simulation. A case study into collision avoidance was used to mark the foundation of the laboratory through the proving of an optimal reciprocal collision avoidance algorithm for the first time in hardware. In the case study, two human-controlled quadrotors were maliciously flown in colliding trajectories. Optimal reciprocal collision avoidance was demonstrated for the first time on completely independent agents with local sensing. The algorithm was shown to be robust to violations of its inherent assumptions about the dynamics of agents and the ability for those agents to sense imminent collisions. These experiments, in addition to the mathematical foundation of exponential convergence, submits th a t optimal reciprocal collision avoidance is a viable method for holonomic robots in both 2-D and 3-D with noisy sensing. A basis for the idea of reciprocal dance, a motion often seen in human collision avoidance, is also suggested in demonstration to be a product of uncertainty about the state of incoming agents. In the more than one hundred tests conducted in multiple environments, no midair collisions were ever produced.