cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hamiltonian Purification
Creators: name: Orsucci, Davide
name: Burgarth, Daniel
name: Facchi, Paolo
name: Nakazato, Hiromichi
name: Pascazio, Saverio
name: Yuasa, Kazuya
name: Giovannetti, Vittorio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The problem of Hamiltonian purification introduced by Burgarth et al. [D. K. Burgarth et al., Nat. Commun. 5, 5173 (2014)] is formalized and discussed. Specifically, given a set of non-commuting Hamiltonians {h1, . . ., hm} operating on a d-dimensional quantum system Hd, the problem consists in identifying a set of commuting Hamiltonians {H1,...,Hm} operating on a larger dE-dimensional system H_{dE} which embeds H_d as a proper subspace, such that hj = PHjP with P being the projection which allows one to recover Hd from HdE . The notions of spanning-set purification and generator purification of an algebra are also introduced and optimal solutions for u(d) are provided.
description: 13 pages, 3 figures
Setting the stage for data science: integration of data management skills in introductory and second courses in statistics
Creators: name: Horton, Nicholas J.
name: Baumer, Benjamin S.
name: Wickham, Hadley
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: Computers and Society (cs.CY)
subject: Other Statistics (stat.OT)
subject: FOS: Computer and information sciences
subject: 62-01

description: Many have argued that statistics students need additional facility to express statistical computations. By introducing students to commonplace tools for data management, visualization, and reproducible analysis in data science and applying these to real-world scenarios, we prepare them to think statistically. In an era of increasingly big data, it is imperative that students develop data-related capacities, beginning with the introductory course. We believe that the integration of these precursors to data science into our curricula-early and often-will help statisticians be part of the dialogue regarding "Big Data" and "Big Questions".
The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing
Creators: name: Skop, A.
name: Spichal, M.
name: Flibotte, S.
name: Heestand, B.
name: Billmyre, K.K.
name: Moerman, D.
name: Belicard, T.
name: Sato-Carlton, A.
name: Sarkies, P.
name: Simon, M.
name: Ahmed, S.
name: Gnazzo, M.
name: Carlton, P.M.
name: Doebley, A.-L.
Publisher: name: Public Library of Science
Year: 2019

description: Germ cell immortality, or transgenerational maintenance of the germ line, could be promoted by mechanisms that could occur in either mitotic or meiotic germ cells. Here we report for the first time that the GSP-2 PP1/Glc7 phosphatase promotes germ cell immortality. Small RNAinduced genome silencing is known to promote germ cell immortality, and we identified a separation-of-function allele of C. elegans gsp-2 that is compromised for germ cell immortality and is also defective for small RNA-induced genome silencing and meiotic but not mitotic chromosome segregation. Previous work has shown that GSP-2 is recruited to meiotic chromosomes by LAB-1, which also promoted germ cell immortality. At the generation of sterility, gsp-2 and lab-1 mutant adults displayed germline degeneration, univalents, histone methylation and histone phosphorylation defects in oocytes, phenotypes that mirror those observed in sterile small RNA-mediated genome silencing mutants. Our data suggest that a meiosisspecific function of GSP-2 ties small RNA-mediated silencing of the epigenome to germ cell immortality. We also show that transgenerational epigenomic silencing at hemizygous genetic elements requires the GSP-2 phosphatase, suggesting a functional link to small RNAs. Given that LAB-1 localizes to the interface between homologous chromosomes during pachytene, we hypothesize that small localized discontinuities at this interface could promote genomic silencing in a manner that depends on small RNAs and the GSP-2 phosphatase.
(502042) Mary Gowans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Collective String Interactions in AdS/QCD and High-Multiplicity pA Collisions
Creators: name: Iatrakis, Ioannis
name: Ramamurti, Adith
name: Shuryak, Edward
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: QCD strings originate from high-energy scattering in the form of Reggeons and Pomerons, and have been studied in some detail in lattice numerical simulations. Production of multiple strings, with their subsequent breaking, is now a mainstream model of high energy $pp$ and $pA$ collisions. Recent LHC experiments revealed that high multiplicity end of such collisions show interesting collective effects. This ignited an interest in the interaction of QCD strings and multi-string dynamics. Holographic models, collectively known as AdS/QCD, developed in the last decade, describe both hadronic spectroscopy and basic thermodynamics, but so far no studies of the QCD strings have been done in this context. The subject of this paper is to do this. First, we study in more detail the scalar sector of hadronic spectroscopy, identifying "glueballs" and "scalar mesons," and calculate the degree of their mixing. The QCD strings, holographic images of the fundamental strings, thus have a "gluonic core" and a "sigma cloud." The latter generates $σ$ exchanges and collectivization of the strings, affecting, at a certain density, the chiral condensate and even the minimum of the effective string potential, responsible for the very existence of the QCD strings. Finally, we run dynamical simulations of the multi-string systems, in the "spaghetti" setting approximating central $pA$ collisions, and specify conditions for their collectivization into a black hole, or the dual QGP fireball.
description: 14 pages, 10 figures
[ARTICLE] Extended Sine and Cosine Functions for Scalene Triangles (Canadian Journal of Mathematics Research / 2022) - GAMMA TRIGONOMETRY
Creators: name: Teia, Luis
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 490499
subject: Pure mathematics not elsewhere classified
classificationCode: 499999
subject: Other mathematical sciences not elsewhere classified

description: This article pushes the role of sine and cosine functions beyond the traditional purpose of determining the sides of a right triangle, into the realm of determining the lengths of the sides of any triangle with practically the same ease. Extended functions are formulated dependent on two angles (instead of the traditional one) — sin*(α,γ) and cos*(α,γ) — that allow (via direct application) the computation of the lengths of the two shorter sides of a scalene triangle, as a result of the angular projection (from reference angle α and a variable obtuse angle γ) of the longer side or extended hypotenuse (for right triangles, the obtuse angle is fixed to γ= 90 deg, allowing only the variation of α — a significant limitation). When integrated into larger more complex mathematical formula, the extended sine and cosine functions add greater flexibility and open the door for the mathematician or scientist to explore possibilities that are non-orthogonal. Solved exercises are provided at the end, with the purpose of illustrating the robustness and advantage of the application of these new extended sine and cosine functions to determine the normalized sides of a scalene triangle — a requirement that is present virtually in any technical discipline.
CopyrightsCopyright for this article is retained by the author(s), with first publication rights granted to the journal. This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).-------------------------------------------------------------------------For more public data, please visit my Figshare profile: https://figshare.com/authors/Luis_Teia/10811244
Measurements of the Sunyaev-Zel'dovich Effect in MACS J0647.7+7015 and MACS J1206.2-0847 at High Angular Resolution with MUSTANG
Creators: name: Young, Alexander H.
name: Mroczkowski, Tony
name: Romero, Charles
name: Sayers, Jack
name: Balestra, Italo
name: Clarke, Tracy E.
name: Czakon, Nicole
name: Devlin, Mark
name: Dicker, Simon R.
name: Ferrari, Chiara
name: Girardi, Marisa
name: Golwala, Sunil
name: Intema, Huib
name: Korngut, Phillip M.
name: Mason, Brian S.
name: Mercurio, Amata
name: Nonino, Mario
name: Reese, Erik D.
name: Rosati, Piero
name: Sarazin, Craig
name: Umetsu, Keiichi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present high resolution (9$^{\prime \prime}$) imaging of the Sunyaev-Zel'dovich Effect (SZE) toward two massive galaxy clusters, MACS J0647.7+7015 ($z=0.591$) and MACS J1206.2-0847 ($z=0.439$). We compare these 90 GHz measurements, taken with the MUSTANG receiver on the Green Bank Telescope, with generalized Navarro-Frenk-White (gNFW) models derived from Bolocam 140 GHz SZE data as well as maps of the thermal gas derived from {\it Chandra} X-ray observations. For MACS J0647.7+7015, we find a gNFW profile with core slope parameter $γ= 0.9$ fits the MUSTANG image with $χ^{2}_{red}=1.005$ and probability to exceed (PTE) = 0.34. For MACS J1206.2-0847, we find $γ=0.7$, $χ^{2}_{red}=0.993$, and PTE = 0.70. In addition, we find a significant ($>$3-$σ$) residual SZE feature in MACS J1206.2-0847 coincident with a group of galaxies identified in VLT data and filamentary structure found in a weak-lensing mass reconstruction. We suggest the detected sub-structure may be the SZE decrement from a low mass foreground group or an infalling group. GMRT measurements at 610 MHz reveal diffuse extended radio emission to the west, which we posit is either an AGN-driven radio lobe, a bubble expanding away from disturbed gas associated with the SZE signal, or a bubble detached and perhaps re-accelerated by sloshing within the cluster. Using the spectroscopic redshifts available, we find evidence for a foreground ($z=0.423$) or infalling group, coincident with the residual SZE feature.
description: 14 pages, 14 figures, 7 tables
[ARTICLE] Extended Sine and Cosine Functions for Scalene Triangles (Canadian Journal of Mathematics Research / 2022)
Creators: name: Teia, Luis
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 490402
subject: Algebraic and differential geometry
classificationCode: 490499
subject: Pure mathematics not elsewhere classified
classificationCode: 490411
subject: Real and complex functions (incl. several variables)
classificationCode: 490199
subject: Applied mathematics not elsewhere classified
classificationCode: 490401
subject: Algebra and number theory

description: ABSTRACT This article pushes the role of sine and cosine functions beyond the traditional purpose of determining the sides of a right triangle, into the realm of determining the lengths of the sides of any triangle with practically the same ease. Extended functions are formulated dependent on two angles (instead of the traditional one) — sin*(α,γ) and cos*(α,γ) — that allow (via direct application) the computation of the lengths of the two shorter sides of a scalene triangle, as a result of the angular projection (from reference angle α and a variable obtuse angle γ) of the longer side or extended hypotenuse (for right triangles, the obtuse angle is fixed to γ= 90 deg, allowing only the variation of α — a significant limitation). When integrated into larger more complex mathematical formula, the extended sine and cosine functions add greater flexibility and open the door for the mathematician or scientist to explore possibilities that are non-orthogonal. Solved exercises are provided at the end, with the purpose of illustrating the robustness and advantage of the application of these new extended sine and cosine functions to determine the normalized sides of a scalene triangle — a requirement that is present virtually in any technical discipline.
Telomeric small RNAs in the genus Caenorhabditis
Creators: name: Ahmed, S.
name: Frenk, S.
name: Lister-Shimauchi, E.H.
Publisher: name: Cold Spring Harbor Laboratory Press
Year: 2019

description: Telomeric DNA is composed of simple tandem repeat sequences and has a G-rich strand that runs 5′′ to 3′′ toward the chromosome terminus. Small RNAs with homology to telomeres have been observed in several organisms and could originate from telomeres or from interstitial telomere sequences (ITSs), which are composites of degenerate and perfect telomere repeat sequences found on chromosome arms. We identified Caenorhabditis elegans small RNAs composed of the Caenorhabditis telomere sequence (TTAGGC)n with up to three mismatches, which might interact with telomeres. We rigorously defined ITSs for genomes of C. elegans and for two closely related nematodes, Caenorhabditis briggsae and Caenorhabditis remanei. Most telomeric small RNAs with mismatches originated from ITSs, which were depleted from mRNAs but were enriched in introns whose genes often displayed hallmarks of genomic silencing. C. elegans small RNAs composed of perfect telomere repeats were very rare but their levels increased by several orders of magnitude in C. briggsae and C. remanei. Major small RNA species in C. elegans begin with a 5′′ guanine nucleotide, which was strongly depleted from perfect telomeric small RNAs of all three Caenorhabditis species. Perfect G-rich or C-rich telomeric small RNAs commonly began with 5′′ UAGGCU and 5′′ UUAGGC or 5′′ CUAAGC, respectively. In contrast, telomeric small RNAs with mismatches had a mixture of all four 5′′ nucleotides. We suggest that perfect telomeric small RNAs have a mechanism of biogenesis that is distinct from known classes of small RNAs and that a dramatic change in their regulation occurred during recent Caenorhabditis evolution.
Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause
Creators: name: Heestand, B.
name: Titov, D.
name: Frenk, S.
name: Ahmed, S.
name: Simon, M.
Publisher: name: Elsevier B.V.
Year: 2018

description: Environmental stress can induce adult reproductive diapause, a state of developmental arrest that temporarily suspends reproduction. Deficiency for C. elegans Piwi protein PRG-1 results in strains that reproduce for many generations but then become sterile. We found that sterile-generation prg-1/Piwi mutants typically displayed pronounced germ cell atrophy as L4 larvae matured into 1-day-old adults. Atrophied germlines spontaneously reproliferated across the first days of adulthood, and this was accompanied by fertility for day 2–4 adults. Sterile day 5 prg-1 mutant adults remained sterile indefinitely, but providing an alternative food source could restore their fertility. Our data imply that late-generation prg-1 mutants experience a dynamic form of adult reproductive diapause, promoted by stress response, cell death, and RNAi pathways, where delayed fertility and reproductive quiescence represent parallel adaptive developmental outcomes. This may occur in response to a form of “heritable stress” that is transmitted by gametes and epigenetic in nature. Heestand et al. examine a form of diapause that occurs in late-generation C. elegans Piwi/prg-1 mutants. They argue that the sterility of late-generation prg-1 mutants may be a consequence of “heritable stress.” Thus, an endogenous form of stress may be transmitted by germ cells to modulate heredity and fertility.
(502035) Jane Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502037) Benjamin Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A law of the iterated logarithm for Grenander's estimator
Creators: name: Duembgen, Lutz
name: Wellner, Jon A.
name: Wolff, Malcolm
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 60F15, 60F17, 62E20, 62F12, 62G20

description: In this note we prove the following law of the iterated logarithm for the Grenander estimator of a monotone decreasing density: If $f(t_0) > 0$, $f'(t_0) < 0$, and $f'$ is continuous in a neighborhood of $t_0$, then \begin{eqnarray*} \limsup_{n\rightarrow \infty} \left ( \frac{n}{2\log \log n} \right )^{1/3} ( \widehat{f}_n (t_0 ) - f(t_0) ) = \left| f(t_0) f'(t_0)/2 \right|^{1/3} 2M \end{eqnarray*} almost surely where $ M \equiv \sup_{g \in {\cal G}} T_g = (3/4)^{1/3}$ and $ T_g \equiv \mbox{argmax}_u \{ g(u) - u^2 \} $; here ${\cal G}$ is the two-sided Strassen limit set on $R$. The proof relies on laws of the iterated logarithm for local empirical processes, Groeneboom's switching relation, and properties of Strassen's limit set analogous to distributional properties of Brownian motion.
description: 11 pages, 3 figures
[ARTICLE] Extended Angle Sum and Difference Identity Rules for Scalene Triangles (Canadian Journal of Mathematics Research / 2022) - GAMMA TRIGONOMETRY
Creators: name: Teia, Luis
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 490401
subject: Algebra and number theory
classificationCode: 490402
subject: Algebraic and differential geometry
classificationCode: 490499
subject: Pure mathematics not elsewhere classified
classificationCode: 490411
subject: Real and complex functions (incl. several variables)
classificationCode: 490199
subject: Applied mathematics not elsewhere classified

description: The present article extends the applicability of the angle sum and difference identity rules sin(A±B) and cos(A±B) beyond the particular case of a right-angled triangle into the general case of scalene triangles as sin*(A±B,γ) and cos*(A±B,γ), adding the effect of independently varying both the reference angle α = A±B and the obtuse angle γ. Accompanied by appropriate theorems and proofs, the mathematical end result are four updated equations that supersede the traditional expressions sin(A±B) = sin(A)cos(b)± cos(A)sin(B) and cos(A±B) = cos(α)cos(B) ∓ sin(A) sin(B), where the conventional sin(α) and cos(α) functions are replaced by the [already proven] extended versions sin*(α,γ) and cos*(α,γ) enclosing modifications including two angles α and γ. An open-source program scripted in Octave is provided for the verification of the derived expressions, including plotting the geometric results as a figure for both the cases of angle summation and subtraction.NOTE: The second link at the bottom provides access to the article about the extended sine function sin*(α,γ) and extended cosine function cos*(α,γ).
CopyrightsCopyright for this article is retained by the author(s), with first publication rights granted to the journal. This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).-------------------------------------------------------------------------For more public data, please visit my Figshare profile: https://figshare.com/authors/Luis_Teia/10811244
Modeling the anomaly of surface number densities of galaxies on the Galactic extinction map due to their FIR emission contamination
Creators: name: Kashiwagi, Toshiya
name: Suto, Yasushi
name: Taruya, Atsushi
name: Kayo, Issha
name: Nishimichi, Takahiro
name: Yahata, Kazuhiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The most widely used Galactic extinction map (Schlegel, Finkbeiner, & Davis 1998, SFD) is constructed assuming that the observed FIR fluxes entirely come from the Galactic dust. According to the earlier suggestion by Yahata et al. (2007), we consider how far-infrared (FIR) emission of galaxies affects the SFD map. We first compute the surface number density of SDSS DR7 galaxies as a function of the $r$-band extinction, $A_{r,\rm SFD}$. We confirm that the surface densities of those galaxies positively correlate with $A_{r,\rm SFD}$ for $A_{r,\rm SFD}<0.1$, as first discovered by Yahata et al. (2007) for SDSS DR4 galaxies. Next we construct an analytic model to compute the surface density of galaxies taking account of the contamination of their FIR emission. We adopt a log-normal probability distribution for the ratio of $100μ{\rm m}$ and $r$-band luminosities of each galaxy, $y \equiv (νL)_{100μ{\rm m}}/(νL)_r$. Then we search for the mean and r.m.s values of $y$ that fit the observed anomaly using the analytic model. The required values to reproduce the anomaly are roughly consistent with those measured from the stacking analysis of SDSS galaxies (Kashiwagi, Yahata, & Suto 2013). Due to the limitation of our statistical modeling, we are not yet able to remove the FIR contamination of galaxies from the extinction map. Nevertheless the agreement with the model prediction suggests that the FIR emission of galaxies is mainly responsible for the observed anomaly. While the corresponding systematic error in the Galactic extinction map is 0.1 to 1mmag, it is directly correlated with galaxy clustering, and thus needs to be carefully examined in precision cosmology.
description: 20 pages, 12 figures, accepted for publication in ApJ
[ARTICLE] Extended Angle Sum and Difference Identity Rules for Scalene Triangles (Canadian Journal of Mathematics Research / 2022) - GAMMA TRIGONOMETRY
Creators: name: Teia, Luis
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 490401
subject: Algebra and number theory
classificationCode: 490199
subject: Applied mathematics not elsewhere classified
classificationCode: 490402
subject: Algebraic and differential geometry
classificationCode: 490499
subject: Pure mathematics not elsewhere classified
classificationCode: 490411
subject: Real and complex functions (incl. several variables)

description: ABSTRACT The present article extends the applicability of the angle sum and difference identity rules sin(A±B) and cos(A±B) beyond the particular case of a right-angled triangle into the general case of scalene triangles as sin*(A±B,γ) and cos*(A±B,γ), adding the effect of independently varying both the reference angle α = A±B and the obtuse angle γ. Accompanied by appropriate theorems and proofs, the mathematical end result are four updated equations that supersede the traditional expressions sin(A±B) = sin(A)cos(b)± cos(A)sin(B) and cos(A±B) = cos(α)cos(B) ∓ sin(A) sin(B), where the conventional sin(α) and cos(α) functions are replaced by the [already proven] extended versions sin*(α,γ) and cos*(α,γ) enclosing modifications including two angles α and γ. An open-source program scripted in Octave is provided for the verification of the derived expressions, including plotting the geometric results as a figure for both the cases of angle summation and subtraction.
(502039) Elizabeth Webb
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dual-targeting CAR-T cells with optimal co-stimulation and metabolic fitness enhance antitumor activity and prevent escape in solid tumors
Creators: name: Xu, Y.
name: Du, H.
name: Savoldo, B.
name: Dotti, G.
name: Hirabayashi, K.
name: Chen, Y.
name: Landoni, E.
name: Fucá, G.
name: Shou, P.
name: Zhou, X.
name: Sun, C.
Publisher: name: Nature Research
Year: 2021

description: Chimeric antigen receptor (CAR)-T cells showed great activity in hematologic malignancies. However, heterogeneous antigen expression in tumor cells and suboptimal CAR-T-cell persistence remain critical aspects to achieve clinical responses in patients with solid tumors. Here we show that CAR-T cells targeting simultaneously two tumor-associated antigens and providing trans-acting CD28 and 4-1BB co-stimulation, while sharing the same CD3ζ-chain cause rapid antitumor effects in in vivo stress conditions, protection from tumor re-challenge and prevention of tumor escape due to low antigen density. Molecular and signaling studies indicate that T cells engineered with the proposed CAR design demonstrate sustained phosphorylation of T-cell-receptor-associated signaling molecules and a molecular signature supporting CAR-T-cell proliferation and long-term survival. Furthermore, metabolic profiling of CAR-T cells displayed induction of glycolysis that sustains rapid effector T-cell function, but also preservation of oxidative functions, which are critical for T-cell long-term persistence.
(502040) Benjamin Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Introduction
Creators: name: Nzongola-Ntalaja, Georges
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: I am extremely proud to present this sixth volume of our undergraduate research journal in the
Department of African, African American, and Diaspora Studies. Some of the papers in this
issue were originally presented at our annual undergraduate research conference, where the best
of our students exhibit their love of learning and commitment to research in the sciences and the
humanities.
Model derivation and toggle switch simulation from Modelling co-translational dimerization for programmable nonlinearity in synthetic biology
Creators: name: Stoof, Ruud
name: Goñi-Moreno, Ángel
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified

description: Derivation of the parameter alpha in Equation 3, and simulation of the toggle switch at alpha = 0.
title: Semi-parametric mixture models with ranked set samples
Creators: name: Moniri, Seyed Jalaleddin
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: Simple random sampling (SRS) is the common method in data collection. In many applications, measuring the variable of interest is costly, but ranking the units can be done easily. In these situations, one can use rank set sampling (RSS) to get more representative samples from the population. This thesis investigates the estimation of the semi-parametric finite mixture models (FMMs) with RSS. We develop a semiparametric version of the Expectation-Maximization (EM) algorithm to obtain the maximum likelihood (ML) estimate of the population with RSS data. We then propose the ML estimation of FMM with RSS data in a semi-parametric framework. Our numerical studies show that the proposed EM algorithm estimates more efficiently the FMM. The proposed methods are finally applied to analyze the bone mineral data.
(502033) Ann Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502034) Thomas Benjamin Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502036) Charles Benjamin Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The influence of hydrostatic pressure on the macro- and micro-structures of aluminium-4% copper alloys
Creators: name: Ho-In Lee
Publisher: name: Loughborough University
Year: 2020
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: The influence of hydrostatic pressure on the macro- and micro-structures of aluminium-4% copper alloys
“The Color of African Unity”: The Pan-Africanist Rhetoric and Praxis of Thomas Sankara in the Burkina Faso Revolution, 1983–87
Creators: name: Muiruri, Kimathi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: In 1983, Captain Thomas Sankara was hoisted to the position of chairman of Upper Volta’s
Conseil National de la Révolution on the back of a military coup, and at once became the
president of the small West African state. He assumed office by pronouncing bold promises that
his regime would be different than those of the nation’s past, including a commitment to a
transformational development scheme that would make the country economically self-sufficient.
Sankara, as a self-described African revolutionary, contended with not only the behemoth selfimposed
task of national development, but also with another challenge: the expectation that he
live up to the legacies of Africa’s past post-colonial revolutionaries—many of whom were out of
power by the time of his ascension. During his short reign, from 1983 to 1987, he would not only
re-name the nation to Burkina Faso and launch massive programs to ameliorate the
underdevelopment that plagued rural areas, but also made concerted efforts to build upon the
ideals of Pan-Africanism on a continent where political agency was uneven and uncertain. This
article analyzes how, from the mantle of a poor, aid-dependent country, Sankara approached the
project of discursively and materially advancing Pan-Africanism. This article concludes that
Sankara’s rhetoric, endogenous development, and international policy promoted a specific brand
of Pan-Africanism that privileged solidarity with working-class Africans at the expense of intergovernmental
harmony. Simultaneously, the material reality of Burkina Faso’s capacity limited
his substantive efforts to those that affected continental Pan-African influence, rather than
international connections with the diaspora.
Coppedge v. Franklin and Swann v. Charlotte-Mecklenburg: The Contributions Toward the Fight for Desegregation in North Carolina Public Schools
Creators: name: Fantauzzi, Sophia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The fight for school desegregation in North Carolina was a hard fought and long battle. Despite
1954–55 Brown v. Board of Education decisions of the US Supreme Court, school desegregation
persisted. The significance of the first and second Brown decisions (often referred to as Brown I
and Brown II) was not overlooked but challenged because of how the Brown decision
underestimated how to fully eliminate barriers that manifested through unequal treatment and
funding of segregated schools. North Carolina politicians employed mechanisms such as
freedom of choice plans, the Pupil Assignment Act, and the Pearsall Plan to ensure the slow
integration of North Carolina public schools. The evaluation of public opinion, North Carolina
politics, and legal decisions employs a robust image of the battle between those who wanted
integration and those who were staunch proponents of segregated schooling. This article
provides an understanding of North Carolina’s “moderate” reputation and evaluates the
compliance of North Carolina government officials to national legislation such as the Civil
Rights Act of 1964 and federal financial assistance measures through the 1965 Elementary and
Secondary Education Act. By analyzing national government legislation put forth in congruence
with the fourth circuit district court case Coppedge v. Franklin County Board of Education
[1967] and the Supreme Court case Swann v. Charlotte-Mecklenburg Board of Education [1971],
this article shows the contributions of two legal cases to the desegregation of North Carolina
public schools
The chemical evolution of galaxies with a variable IGIMF
Creators: name: Recchi, S.
name: Kroupa, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Standard analytical chemical evolution modelling of galaxies has been assuming the stellar initial mass function (IMF) to be invariant and fully sampled allowing fractions of massive stars to contribute even in dwarf galaxies with very low star formation rates (SFRs). Recent observations show the integrated galactic initial mass function (IGIMF) of stars, i.e. the galaxy-wide IMF, to become systematically top-heavy with increasing SFR. This has been predicted by the IGIMF theory, which is here used to develop the analytical theory of the chemical evolution of galaxies. This theory is non-linear and requires the iterative solution of implicit integral equations due to the dependence of the IGIMF on the metallicity and on the SFR. It is shown that the mass-metallicity relation of galaxies emerges naturally, although at low masses the theoretical predictions overestimate the observations by 0.3--0.4 dex. A good agreement with the observation can be obtained only if gas flows are taken into account. In particular, we are able to reproduce the mass--metallicity relation observed by Lee et al. (2006) with modest amounts of infall and with an outflow rate which decreases as a function of the galactic mass. The outflow rates required to fit the data are considerably smaller than required in models with invariant IMFs.
description: 8 pages, 5 figures, MNRAS, accepted
Negative anomalous dimensions in N=4 SYM
Creators: name: Kimura, Yusuke
name: Suzuki, Ryo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We elucidate aspects of the one-loop anomalous dimension of $so(6)$-singlet multi-trace operators in $\mathcal{N}=4\ SU(N_c)$ SYM at finite $N_c$. First, we study how $1/N_c$ corrections lift the large $N_c$ degeneracy of the spectrum, which we call the operator submixing problem. We observe that all large $N_c$ zero modes acquire non-positive anomalous dimension starting at order $1/N_c^2$, and they mix only among the operators with the same number of traces at leading order. Second, we study the lowest one-loop dimension of operators of length equal to $2N_c$. The dimension of such operators becomes more negative as $N_c$ increases, which will eventually diverge in a double scaling limit. Third, we examine the structure of level-crossing at finite $N_c$ in view of unitarity. Finally we find out a correspondence between the large $N_c$ zero modes and completely symmetric polynomials of Mandelstam variables.
description: 34+31 pages, many figures, a Mathematica file attached, v2: typos corrected, references added, section 5 revised, v3: revised Section 4 on correlators, and small details
Toward Air-Stable Multilayer Phosphorene Thin-Films and Transistors
Creators: name: Kim, Joon-Seok
name: Liu, Yingnan
name: Zhu, Weinan
name: Kim, Seohee
name: Wu, Di
name: Tao, Li
name: Dodabalapur, Ananth
name: Lai, Keji
name: Akinwande, Deji
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Few-layer black phosphorus (BP), also known as phosphorene, is poised to be the most attractive graphene analogue owing to its high mobility approaching that of graphene, and its thickness- tunable band gap that can be as large as that of molybdenum disulfide. In essence, phosphorene represents the much sought after high-mobility, large direct band gap two-dimensional layered crystal that is ideal for optoelectronics and flexible devices. However, its instability in air is of paramount concern for practical applications. Here, we demonstrate air-stable BP devices with dielectric and hydrophobic encapsulation. Microscopy, spectroscopy, and transport techniques were employed to elucidate the aging mechanism, which can initiate from the BP surface for bare samples, or edges for samples with thin dielectric coating highlighting the ineffectiveness of conventional scaled dielectrics. Our pioneering months-long studies indicate that a double layer of Al2O3 and hydrophobic fluoropolymer affords BP devices and transistors with indefinite air-stability for the first time, overcoming a critical material challenge for applied research and development.
description: 22 pages, 4 figures
(502030) Mary Frances Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502031) Frances Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Interconnectedness of Black Liberation: The Cross-Political Relationship of African and African American Leaders in the Struggle for Independence and the Civil Rights Movement (1950–60)
Creators: name: Yakubu, Mina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The linkages between African and African American freedom advocates began long before their
demands actualized in the latter half of the 1950s and early 1960s. Some of the leaders of this
global Black movement for self-determination met when they were students at historically Black
colleges and universities (HBCUs) in the United States, notably, Lincoln University and Howard
University. While these movements and their aims were generally connected, this article
examines the close relationships of their political leaders. It was partly through their relationships
that they were able to advance their political demands for freedom. The article explores the
cross-political ties of African leaders Kwame Nkrumah and Nnamdi Azikiwe, and of African
American leaders like W.E.B. Du Bois, in their respective movements for human rights
recognition from 1950 to the early 1960s. This was a time in which legal segregation and racial
violence targeted Black people in the United States and the presence of European colonialism
encroached on the sovereignty of Africans. This article explores how these political relations and
the events of these movements influenced one another. This research intends to help readers
understand the interconnectedness of the global Black struggle for self-determination,
specifically as it relates to African American Civil Rights leaders and the leaders of
independence movements in Africa like Azikiwe and Nkrumah, who would become the first
presidents of Nigeria and Ghana, respectively.
The Green Belt Movement: Women, Land, and Development
Creators: name: Kinoti, Kyende
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Environmental degradation is one of the most prevalent and devastating issues in our
contemporary world. As discourses on how to curb increasing environmental deterioration
continue to emerge, it has become clear that the Earth’s ecosystems cannot thrive in tandem with
hyper-modernization projects pursuing Western conceptions of development. As the
ramifications of environmental degradation become more apparent in our daily lives, it is also
evident that Southern women are disproportionately affected by ills brought about by the
destruction of ecosystems. In light of our current gendered environmental crisis, this article
offers a historical exploration of how the Green Belt Movement (GBM)—an organization
founded in Kenya in 1977—engaged in programs and advocacy to empower rural women and
conserve the environment. The GBM’s activities were particularly groundbreaking due to their
occurrence at a time when conversations surrounding environmental protection were not
mainstream and took the backseat to development goals evoked by modernization theory. To
contextualize the GBM’s emergence, the article explores how agrarian policies in colonial and
post-colonial Kenya led to deforestation and natural resource depletion. The article then offers
gender and development (GAD) and intersectionality literature as ways to better understand the
GBM’s interventions to restore natural habitats. The GBM’s tree planting, education, and
advocacy programs are underlined as being instrumental in encouraging authentic design within
communities, challenging hyper-modernization in Kenya, and shifting rural women’s gender
roles. The article ultimately aims to highlight the importance of indigenous knowledge and local
activism in creating a sustainable future.
(502032) Robert Benjamin Woodman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.