cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The metallicity dependence of envelope inflation in massive stars
Creators: name: Sanyal, D.
name: Langer, N.
name: Szécsi, D.
name: Yoon, S. -C
name: Grassitelli, L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recently it has been found that models of massive stars reach the Eddington limit in their interior, which leads to dilute extended envelopes. We perform a comparative study of the envelope properties of massive stars at different metallicities, with the aim to establish the impact of the stellar metallicity on the effect of envelope inflation. We analyse published grids of core-hydrogen burning massive star models computed with metallicities appropriate for massive stars in the Milky Way, the LMC and the SMC, the very metal poor dwarf galaxy I Zwicky 18, and for metal-free chemical composition. Stellar models of all the investigated metallicities reach and exceed the Eddington limit in their interior, aided by the opacity peaks of iron, helium and hydrogen, and consequently develop inflated envelopes. Envelope inflation leads to a redward bending of the zero-age main sequence and a broadening of the main sequence band in the upper part of the Hertzsprung-Russell diagram. We derive the limiting L/M-values as function of the stellar surface temperature above which inflation occurs, and find them to be larger for lower metallicity. While Galactic models show inflation above ~29 Msun, the corresponding mass limit for Population III stars is ~150 Msun. While the masses of the inflated envelopes are generally small, we find that they can reach 1-100 Msun in models with effective temperatures below ~8000 K, with higher masses reached by models of lower metallicity. Envelope inflation is expected to occur in sufficiently massive stars at all metallicities, and is expected to lead to rapidly growing pulsations, high macroturbulent velocities, and might well be related to the unexplained variability observed in Luminous Blue Variables like S Doradus and Eta Carina.
description: 16 pages (with Appendix), accepted in A&A
Optimizing the Vertical Vibration on Rail Vehicle Dynamic for Passenger Comfort
Creators: name: Wenzie, Amare
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2016

description: Investigation of vibration is an important topic for the purposes of ride comfort in railway engineering. The vibration of rail vehicles becomes very complex because it is affected by the condition of vehicles, including suspensions and wheel profile, condition of track sections, including rail profile, rail irregularities, cant and curvature. This thesis aims at optimizing validated modelling methods to study its dynamics, how it influences on vertical vibration, how it excited on track and how it interacts with the passengers. The primary interest is ride comfort, considering the standard vibrations frequency range. In the standard frequency range, the structural flexibility of the carbody is concern. The models are intended for use in time-domain simulation, calling for small-sized models to reduce computational time and costs. Key parameters are proposed to select carbody eignmodes for inclusion in a flexible multibody model. Numerical simulations can be used to evaluate the comfort index at the railway vehicles. To this purpose, a melty-body modelling system is used that takes into account a string of factors influencing the level of the vertical vibrations, thus allowing a correct evaluation of the dynamic behavior in the railway vehicles, mainly at high velocities. The influence of the vertical suspension features upon the vibrating comfort will be examined, as a function of velocity. The concept of the critical point of the rail vehicle vibration behavior is introduced, as the point where the comfort index is the highest. While assuming the idea to minimize the level of vibrations in the critical point, it is thus proven the possibility of establishing the best damping of the vertical suspension that leads to the best values of the comfort index. Finally, the effects of different parameters and the optimized parameters are carried.
NEW INSIGHTS ON THE AGAMOUS SUBFAMILY GENES IN ORYZA SATIVA
Creators: name: RAVASIO, ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: More than 30 years of plant biology have assessed the tight relationship existing between MADS-box genes and plant development and reproduction. Transcription factors of the MADS-box family have been associated with crucial processes throughout the whole life plant: germination, hormonal signalling, vegetative growth, transition from vegetative to reproductive phase, flower, fruit and seed development, embryogenesis. MADS-box are key regulators of the gene networks behind all of these processes; therefore, they have been (and continue to be) the subject of a number of molecular and functional studies which aim to add more and more details on the overall picture of how plants are made. Among MADS-box, the AGAMOUS subfamily plays a fundamental role in plant reproduction; genes belonging to this subfamily have been associated with reproductive organ development and seed and fruit development in many different species. During evolution, the AGAMOUS subfamily underwent various events of duplication which led to the presence, in the extant plant species, of multiple AGAMOUS-like genes, often acquiring different functions thanks to subfunctionalization and neofunctionalization. The aim of this thesis is to shed some more light upon the AGAMOUS-like genes present in rice (Oryza sativa). In the first part, we demonstrate how the alternative splicing of a single aminoacid in rice AGAMOUS ortholog OsMADS3 can alter its functionality, as proven by the different ability of the two isoforms to interact with other MADS-box proteins and by the different phenotype generated by their ectopic expression in A. thaliana. In the second part, we present preliminary data about the role of rice AGAMOUS subfamily genes in controlling rice seed development. AGAMOUS-like genes have been associated with fruit and seed development in various species, but functional characterization experiments are difficult to perform on fruit plants because of their long life cycle; thus, rice represent the perfect model species to start with. Our experiments show that in multiple mutants in AGAMOUS-like genes fertility and seed development are severely impaired.
Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine
Creators: name: Wang, Shao-Ming
name: Wu, Hsiang-En
name: Yasui, Yuko
name: Geva, Michal
name: Hayden, Michael
name: Maurice, Tangui
name: Cozzolino, Mauro
name: Su, Tsung-Ping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: Macroautophagy/autophagy is an essential process for cellular survival and is implicated in many diseases. A critical step in autophagy is the transport of the transcription factor TFEB from the cytosol into the nucleus, through the nuclear pore (NP) by KPNB1/importinβ1. In the C9orf72 subtype of amyotrophic lateral sclerosis-frontotemporal lobar degeneration (ALS-FTD), the hexanucleotide (G4C2)RNA expansion (HRE) disrupts the nucleocytoplasmic transport of TFEB, compromising autophagy. Here we show that a molecular chaperone, the SIGMAR1/Sigma-1 receptor (sigma non-opioid intracellular receptor 1), facilitates TFEB transport into the nucleus by chaperoning the NP protein (i.e., nucleoporin) POM121 which recruits KPNB1. In NSC34 cells, HRE reduces TFEB transport by interfering with the association between SIGMAR1 and POM121, resulting in reduced nuclear levels of TFEB, KPNB1, and the autophagy marker LC3-II. Overexpression of SIGMAR1 or POM121, or treatment with the highly selective and potent SIGMAR1 agonist pridopidine, currently in phase 2/3 clinical trials for ALS and Huntington disease, rescues all of these deficits. Our results implicate nucleoporin POM121 not merely as a structural nucleoporin, but also as a chaperone-operated signaling molecule enabling TFEB-mediated autophagy. Our data suggest the use of SIGMAR1 agonists, such as pridopidine, for therapeutic development of diseases in which autophagy is impaired. Abbreviations: ALS-FTD, amyotrophic lateral sclerosis-frontotemporal dementiaC9ALS-FTD, C9orf72 subtype of amyotrophic lateral sclerosis-frontotemporal dementiaCS, citrate synthaseER, endoplasmic reticulumGSS, glutathione synthetaseHRE, hexanucleotide repeat expansionHSPA5/BiP, heat shock protein 5LAMP1, lysosomal-associated membrane protein 1MAM, mitochondria-associated endoplasmic reticulum membraneMAP1LC3/LC3, microtubule-associated protein 1 light chain 3NP, nuclear poreNSC34, mouse motor neuron-like hybrid cell lineNUPs, nucleoporinsPOM121, nuclear pore membrane protein 121SIGMAR1/Sigma-1R, sigma non-opioid intracellular receptor 1TFEB, transcription factor EBTMEM97/Sigma-2R, transmembrane protein 97
An analysis of fluctuations in unitary synaptic potentials evoked in cat motoneurones
Creators: name: Wong., K.T.K.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Rollingstock Maintenance Strategy Selection by Application of the Analytic Network Process Algorithm
Creators: name: Catherine, Atuheise
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: Industries are facing a lot of challenges such as the optimization of operation and maintenance function due to the continually evolving world of technologies, global competitiveness, environmental and safety requirements. Thus, this study sets out to select an appropriate maintenance strategy with the use of one of the various Multi-Criteria Decision Making (MCDM) methods known as Analytic Network Process (ANP). This study is aimed at selecting an appropriate maintenance strategy to be adopted at AALRTS. This consists of determination of evaluating criteria and maintenance strategies to be used in the study. Thereafter, there is formation of a model, pairwise comparisons based on the model formulated and validation of a model and to achieve this, a survey is carried out in three phases using questionnaires to be filled by a group of experts from the Addis Ababa University, Ethiopian Railway Corporation and Addis Ababa Light Rail Transit depot maintenance and management personnel to narrow down the evaluating criteria that were gotten from the literature review. The model used to analyze and evaluate the data is Analytic Network Process (ANP) and a software, SUPERDECISION is used to assist with the analysis. The results obtained is Total Productive Maintenance as the most recommended suitable maintenance strategies and Corrective maintenance as the least recommended alternative. The strategies currently being utilized at AALRT are preventive maintenance and corrective maintenance. Application of the new recommended strategy (CBM & TPM) can improve company operations, improve the whole system safety, improve company profitability and hence competitiveness.
The Importance of the Electron Mean Free Path for Superconducting RF Cavities
Creators: name: Maniscalco, J. T.
name: Gonnella, D.
name: Liepe, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Impurity-doping is an exciting new technology in the field of SRF, producing cavities with record-high quality factor $Q_0$ and BCS surface resistance that decreases with increasing RF field. Recent theoretical work has offered a promising explanation for this anti-Q-slope, but the link between the decreasing surface resistance and the short mean free path of doped cavities has remained elusive. In this work we investigate this link, finding that the magnitude of this decrease varies directly with the mean free path: shorter mean free paths correspond with stronger anti-Q-slopes. We draw a theoretical connection between the mean free path and the overheating of the quasiparticles, which leads to the reduction of the anti-Q-slope towards the normal Q-slope of long-mean-free-path cavities. We also investigate the sensitivity of the residual resistance to trapped magnetic flux, a property which is greatly enhanced for doped cavities, and calculate an optimal doping regime for a given amount of trapped flux.
description: 17 pages, 15 figures (including subfigures)
Skyrme model study of proton and neutron properties in a strong magnetic field
Creators: name: He, Bing-Ran
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The proton and neutron properties in a uniform magnetic field are investigated. The Gell-Mann-Nishijima formula is shown to be satisfied for baryon states. It is found that with increasing magnetic field strength, the proton mass first decreases and then increases, while the neutron mass always increases. The ratio between magnetic moment of proton and neutron increases with the increase of the magnetic field strength. With increasing magnetic field strength, the size of proton first increases and then decreases, while the size of neutron always decreases. The present analyse implies that in the core part of the magnetar, the equation of state depend on the magnetic field, which modifies the mass limit of the magnetar.
description: 5 pages, 6 figures
Newsletter 3. Half of the project achieved
Creators: name: Edenway
Publisher: name: Zenodo
Year: 2018
Subjects: subject: newsletter
subject: https://shoutout.wix.com/so/dM0nT6iP#/main

description: CHESS SETUP: STEP 3 CHESS SETUP coming into tangible actions Welcome to our 3rd newsletter, we wish you a pleasant reading
The Role of Hexokinase 2 in the Regulation of Histone Lactylation
Creators: name: Rho, Hyunsoo
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Lactate, previously considered as a metabolic waste product, has been implicated in the induction of gene expression in activated hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains unknown. We demonstrate that the catalytic activity of hexokinase 2 (HK2) is sufficient to alter gene expression by histone lactylation but not histone acetylation. Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of HK2 expression in activated HSCs is required for the induction of gene expression in activated HSCs via an increase in histone lactylation. Inhibiting histone lactylation through genetic deletion of Hk2 or pharmacological inhibition of lactate production diminishes HSC activation, whereas exogenous lactate supplementation, but not acetate supplementation, restores the activation phenotype. Thus, lactate produced by activated HSCs determines the HSC fate via histone lactylation. We also found that histone acetylation and lactylation are in competition, which could explain why class I HDAC inhibitors impede HSC activation and subsequent gene expression. Lastly, we found that HSC-specific or systemic deletion of Hk2 inhibits HSC activation and liver fibrosis in vivo. Therefore, we provide evidence that HK2 may be an effective therapeutic target for liver fibrosis.
Function and Structure of Damaged and Regenerating Corneal Cold Sensitive Nerves
Creators: name: Ivakhnitskaia, Evguenia
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Corneal sensory nerves help protect the ocular surface from damage. Although these nerve endings are able to regenerate from injury, their structure and function can be compromised leading to pain and propagating ocular surface damage. Corneal cold sensitive nerves are the major subtype regulating ocular surface homeostasis. By using extracellular electrophysiology of the trigeminal ganglion combined with immunohistochemistry, this work seeks to show the consequences of corneal nerve damage and regeneration on both the structure and function of corneal cold sensitive nerves. First, it is demonstrated that Benzalkonium chloride (BAK), a common ocular drop preservative, damages the nerve endings of corneal cold sensitive nerves. Subsequently the consequences of corneal regeneration from BAK or ocular debridement injuries are demonstrated, highlighting that different injury models may lead to prolonged and differential effects on corneal nerve properties after regeneration. The findings of this dissertation work help to elucidate the sensory disturbances experienced by people who experience ocular surface damage due to iatrogenic or traumatic causes.
Improved parameters and procedures for flood routing in rivers
Creators: name: Fatt., Tony Wong Hoong
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Resonances in Coupled-Channel Scattering
Creators: name: Wilson, David J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Excited hadrons are seen as resonances in the scattering of lighter stable hadrons like $π$, $K$ and $η$. Many decay into multiple final states necessitating coupled-channel analyses. Recently it has become possible to obtain coupled-channel scattering amplitudes from lattice QCD. Using large diverse bases of operators it is possible to obtain reliable finite volume spectra at energies where multiple channels are open. Utilising the finite volume formalism proposed by Lüscher and extended by several others, scattering amplitudes can be extracted from the finite volume spectra. Recent applications will be discussed where the energy dependence of scattering amplitudes is mapped out in several quantum numbers. These are then continued to complex energies to extract resonance poles and couplings.
description: Invited topical plenary contribution to the 34th International Symposium on Lattice Field Theory (Lattice 2016), 24-30 July 2016, University of Southampton, UK. 15 pages, 10 figures
The Effect of Anticipated Embarrassment on Consumer Preference for Using Chatbots
Creators: name: Sengupta, Rumela
Publisher: name: University of Illinois at Chicago
Year: 2023

description: In recent years, businesses have started using a variety of conversational chatbots to help improve their customer support efforts. The current research examines the influence of anticipated embarrassment on consumers’ willingness to use chatbots for online searches, develop a deeper understanding of the boundary conditions of this effect, and identify design cues that can be employed to encourage chatbot adoption during embarrassing contexts. When faced with a decision of whether to conduct an online search using a chatbot, consumers are less likely to do so when they anticipate feeling embarrassed about the search than when they do not. This reluctance to use chatbots results from a sense of perceived social presence while interacting with a chatbot, which in turn results in fear of being judged by the chatbot while conducting an embarrassing search. Across nine experiments exploring scenarios related to online search, this research demonstrates the phenomenon and investigates the underlying process. A second set of studies investigates individual self-esteem and individual tendency to anthropomorphize as the boundary conditions for the primary effect. Finally, the third set of studies investigates different design cues, e.g., de-anthropomorphizing and imbuing chatbots with empathetic design cues, that can be employed to increase the usage likelihood of chatbots during embarrassing searches. Further, as theorized, consumers (i) prefer to use traditional search tools (vs. chatbots) to conduct embarrassing online searches (because unlike chatbots, these search tools do not possess humanlike features and therefore do not result in feelings of social presence or anticipated judgment) and (ii) are more willing to conduct non-embarrassing (vs. embarrassing) product searches using chatbots (because individuals do not fear being judged for conducting non-embarrassing searches). Together, the findings reveal an unexamined negative impact of anthropomorphizing chatbots, which has important implications for both theory and practice.
The analemma criterion: accidental quasi-satellites are indeed true quasi-satellites
Creators: name: Marcos, C. de la Fuente
name: Marcos, R. de la Fuente
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In the Solar system, a quasi-satellite is an object that follows a heliocentric path with an orbital period that matches almost exactly with that of a host body (planetary or not). The trajectory is of such nature that, without being gravitationally attached, the value of the angular separation between host and quasi-satellite as seen from the Sun remains confined within relatively narrow limits for time-spans that exceed the length of the host's sidereal orbital period. Here, we show that under these conditions, a quasi-satellite traces an analemma in the sky as observed from the host in a manner similar to that found for geosynchronous orbits. The analemmatic curve (figure-eight-, teardrop-, ellipse-shaped) results from the interplay between the tilt of the rotational axis of the host and the properties of the orbit of the quasi-satellite. The analemma criterion can be applied to identify true quasi-satellite dynamical behaviour using observational or synthetic astrometry and it is tested for several well-documented quasi-satellites. For the particular case of 15810 (1994 JR1), a putative accidental quasi-satellite of dwarf planet Pluto, we show explicitly that this object describes a complex analemmatic curve for several Plutonian sidereal periods, confirming its transient quasi-satellite status.
description: 7 pages, 2 figures, 1 table. Revised to match version published in MNRAS
Modeling and Structural Analysis of Railway Vehicle body with Finite Element Method
Creators: name: Belete, Jirru
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2015

description: A train running along a track is one of the most complicated dynamic and static systems in engineering due to having various nature of contacting wheel and rail. The railway vehicle structures generally have the main components of shells, center sill, under frame, and beams, and behavior of these members directly affects static and dynamic structural behaviors of these vehicles. The central structural design Requirements are given by the main static and dynamic loads. The purpose of the study is to model and analyze a rail vehicle carbody structure that solves the issue of strength and comfort. Modern rail vehicles passenger carbodies are designed as lightweight structures with the aim to minimize mass and thus operational energy demand. At the same time the vehicle carbody shall be designed as stiff as possible to withstand exceptional loads. The output of the analysis shows that the maximum deflection occurs at midway of the span of the length and the selected sections for the different components of the rail vehicle are capable of carrying the intended purpose. In addition, the first six natural frequencies are calculated using ANSYS design and modeling software. The frequency is compared to the sensitivity range of human being in vertical ride comfort. The design and analysis is became an input to Railway Corporation and local manufacturer"s that has plant to substitute import by local manufacturing of passenger rail vehicle car bodies.
How Sports-Based Youth Development Staff Support Marginalized Youth Through Multiple Public Health Crises
Creators: name: Tran, Melanie
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Dual public health crises—the COVID-19 pandemic and systemic racism—have amplified existing health inequities, particularly for racial and ethnic minority youth in the United States. Need is high, yet treatment accessibility for vulnerable youth and capacity of traditional school/mental health services are limited. Out-of-school time programs reach >18% of U.S. youth, have a rich history of tackling social issues, and benefit youth academic, physical, and mental health outcomes. One type of program, Sports-Based Youth Development, typically serves underserved youth and is well-positioned to address persistent and rising physical and mental health inequities. SBYD staff are key to delivering quality programs that yield positive outcomes and have been critical in responding to youth needs during the public health crises. Thus, supporting staff is crucial for youth. In this community-based study we collaborated with 6 SBYD programs serving low-child opportunity neighborhoods in Chicago to 1) Describe the well-being of SBYD staff at work, and 2) Characterize how SBYD staff supported youth through dual public health crises. Within a larger study that utilized a mixed method design, surveys were collected to assess staff well-being (e.g., burnout). Maximum variation sampling was used to select participants for 1-hr semi-structured interviews. Ten were eligible and seven were interviewed. SBYD staff (n = 7) answered questions about how they supported youth though the COVID-19 pandemic and a period of heightened racial tensions. Interviews were analyzed via thematic analysis (Braun & Clarke, 2006). Survey results indicated moderate staff burnout and average work engagement. Qualitative findings yielded three main themes: 1) Staff provided holistic support to youth through a range of emotional, instrumental, and informational supports, as well as through building trusted relationships across settings; 2) Staff provided contextually-responsive support; 3) Staff were flexible in responding to youth needs. Findings will be shared with partners to tailor staff support and development, with implications for improving program quality and youth outcomes in communities most impacted by COVID-19 and racial upheaval.
Humanoid navigation on rough terrain with a walking staff
Creators: name: Wong., Edward
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Improving Compressive and Tensile Strength of Slab Sleepers for Railway Bridge by Mechanism of Steel Fiber Reinforced Concrete
Creators: name: Meresa, Tesfay
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: Concrete is a material that needs strengthening in tension in order to meet the structural requirements. New techniques of strengthening concrete, besides the usual ordinary reinforcement bars, are developing; fiber reinforced concrete is one of them. Fibre reinforcement is a method that has been in use over the last 30 years, yet it is unfamiliar in our country Ethiopia. This research study deals with experimental investigation of C-30 grade concrete with the addition of 1% ,1.5% and 2% of steel fiber, 4% & 5% glass fiber and deferent percentage mix of glass steel fibre. For comparison purposes, plain control samples were also considered. This study was undertaken aiming to investigate the mechanical behavior of concrete reinforced with the addition of steel fibers, glass fibre and mix of steel glass fibre hoping to improve the compressive and tensile strength of the plain concrete in order to use on railway bridges slab track in Ethiopia railway projects to prevent cracks on bridge slab sleepers from the reputedly application of static and dynamic loads of the train. The test program was included slump test, compressive strength test, flexural strength test and toughness tests including load-deflection curve for each mix series. And the results show that, workability of fresh concrete was largely influenced by the presence of steel fiber and glass fibre; on the other hand it was unlikely to achieve considerable improvements in compressive strength by glass fiber inclusion but it was steel fiber indicates good improvement on the concrete compressive strength up to 26.37% of relative strength grain comparing with the plain concrete and the flexural tensile strength and the post crack energy absorption were greatly increased with relative strength gain 66.2% and 273.73% respectively. However, further, study is still necessary in order to have a more in-depth understanding of the material interactions and possible practical applications.
Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells
Creators: name: Desideri, Enrico
name: Castelli, Serena
name: Dorard, Coralie
name: Toifl, Stefanie
name: Grazi, Gian Luca
name: Ciriolo, Maria Rosa
name: Baccarini, Manuela
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Impaired degradation of the transcriptional coactivator YAP1 and IL6ST (interleukin 6 cytokine family signal transducer), two proteins deregulated in liver cancer, has been shown to promote tumor growth. Here, we demonstrate that YAP1 and IL6ST are novel substrates of chaperone-mediated autophagy (CMA) in human hepatocellular carcinoma (HCC) and hepatocyte cell lines. Knockdown of the lysosomal CMA receptor LAMP2A increases protein levels of YAP1 and IL6ST, without changes in mRNA expression. Additionally, both proteins show KFERQ-dependent binding to the CMA chaperone HSPA8 and accumulate into isolated lysosomes after stimulation of CMA by prolonged starvation. We further show that LAMP2A downregulation promotes the proliferation and migration in HCC cells and a human hepatocyte cell line, and that it does so in a YAP1- and IL6ST-dependent manner. Finally, LAMP2A expression is downregulated, and YAP1 and IL6ST expression is upregulated, in human HCC biopsies. Taken together, our work reveals a novel mechanism that controls the turnover of two cancer-relevant proteins and suggests a tumor suppressor function of CMA in the liver, advocating for the exploitation of CMA activity for diagnostic and therapeutic purposes. Abbreviations: ACTB: actin beta; ATG5: autophagy related 5; ATG7: autophagy related 7; CMA: chaperone-mediated autophagy; eMI: endosomal microautophagy; HCC: hepatocellular carcinoma; HSPA8: heat shock protein family A (Hsp70) member 8; IL6ST: interleukin 6 cytokine family signal transducer; JAK: Janus kinase; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; MAPK8: mitogen-activated protein kinase 8; P6: pyridine 6; SQSTM1: sequestosome 1; TUBA: tubulin alpha; VDAC1: voltage dependent anion channel 1; VP: verteporfin; YAP1: Yes1 associated transcriptional regulator.
Operator Mixing in Large $N$ Superconformal Field Theories on $\mathbb{S}^4$ and Correlators with Wilson loops
Creators: name: Rodriguez-Gomez, Diego
name: Russo, Jorge G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We find a general formula for the operator mixing on the $\mathbb{S}^4$ of chiral primary operators (CPO) for the ${\cal N}=4$ theory at large $N$ in terms of Chebyshev polynomials. As an application, we compute the correlator of a CPO and a Wilson loop, reproducing an earlier result by Giombi and Pestun obtained from a two-matrix model proposal. Finally, we discuss a simple method to obtain correlators in general ${\cal N}=2$ superconformal field theories in perturbation theory in terms of correlators of the ${\cal N}=4$ theory.
description: 15 pages, no figures
IL CONTRIBUTO ITALIANO ALLA COSTRUZIONE DEL MITO LETTERARIO PESSOANO
Creators: name: ALBERANI, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: This research aims at enlarging the understanding of the value and importance of the Italian contributions which helped create the literary myth of Fernando Pessoa. This kind of research was carried out with a practical approach, in order to collect every Italian publication, in particular works by Pessoa translated into Italian, critical essays about the Portuguese poet, anthologies text book extracts, journal articles, tourist guides and intertextual operations (narrative works, movies, songs, plays?) where Fernando Pessoa?s works and personality are remediated. From a methodological point of view, it was necessary to create a database to collect and analyse the materials and therefore understand the reception of the Portuguese author in our country. The chronological boundaries were established during the works analysis and were determined from the end of the 1930s (the years of the first Italian translation of a Pessoa?s poem) to the present day. The study reveals the main Italian key to the interpretation of Pessoa?s works, while at the same time suggesting to what extent the Italian interpretations were fundamental in the construction of Pessoa?s myth. This research therefore revolves around conceptualizing how the figure of the Portuguese writer is perceived by Italian readers. And which Italian ?filters? returned to the reader, and in general to the Italian ?imaginary?, the Portuguese writer.
Competitive Analysis of Online Cloud Scheduling with Fare Classes
Creators: name: Giarduz, Andrea
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Online cloud scheduling is becoming a key factor in today's market due to the ubiquity of cloud computing. From the cloud providers' point of view, many online algorithms have been created to decide which customers' requests to accept or reject, in order to maximize profits. However, these solutions give performance guarantees based on strict assumptions, such as the input coming from a probability distribution, or by having the customer wait for a decision. A different setting that employs online algorithms to serve similar purposes is the airline industry, and some of its work ensures a certain level of performance without any assumptions or system parameter knowledge. This thesis addresses online cloud scheduling issues using techniques and models from the airline industry. In particular, it divides the incoming requests into fare classes and applies a Nested Protection Level policy to make acceptance decisions. Theoretical results provide bounds on the resulting competitive ratio.
Mentalism, Monthly Illustrated Occult Magazine, No. 03 (February 1907)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Occultism
valueUri: http://id.worldcat.org/fast/1043123
subject: Pseudoscience
valueUri: http://id.worldcat.org/fast/1080912
subject: Medicine, Magic, mystic, and spagiric
valueUri: http://id.worldcat.org/fast/1015272
subject: Parapsychology
valueUri: http://id.worldcat.org/fast/1053079
subject: Psychometry (Parapsychology)
valueUri: http://id.worldcat.org/fast/1081647
subject: Occultism and science
valueUri: http://id.worldcat.org/fast/1043151
subject: Mysticism
valueUri: http://id.worldcat.org/fast/1031629

description: “The Mentalism magazine was published in Moscow in 1906-1908 and 1911. The publication initiative belonged to Russia's first circle of mentalists, and the editor was Nikolai Borisovich Butovt, president of the circle of mentalists, author of the book "The Complete Course of Medical Magnetism and Vitaopathy". The journal included articles, both original and translated, devoted to the popular interpretation of the occult sciences. They cover such issues as mentalism, hypnotism, personal magnetism, therapeutic magnetism, phrenology, physiognomy, graphology, chirosophy and others.” -- translated description from a Russian auction house previously selling individual copies. "These are the equivalent to scientific articles, presented as ‘factually true’ wherein authors detail phenomena, provide research narratives, methodologies, anecdotal evidence and other reflections on occultism and mystical pseudo-science. It is similar to works by Alistair Crowley in England. It also possess a degree of medical and psychological relevance as some of the articles are related to the implementation of occult science in the curing or treatment of common maladies at the time. The founder/editor/publisher was Nikolai Borisovich Butovt (1860-1936) of the first circle of mentalists. The initial pieces in each issue indicate that they had been published in Moscow in the given year. However, the bound volume was likely printed in Minsk, Belarus which at the time was part of the Russian Empire." -- Dr. Tucker D. Farris
Mentalism, Monthly Illustrated Occult Magazine, No. 02 (January 1907)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Occultism and science
valueUri: http://id.worldcat.org/fast/1043151
subject: Pseudoscience
valueUri: http://id.worldcat.org/fast/1080912
subject: Parapsychology
valueUri: http://id.worldcat.org/fast/1053079
subject: Psychometry (Parapsychology)
valueUri: http://id.worldcat.org/fast/1081647
subject: Medicine, Magic, mystic, and spagiric
valueUri: http://id.worldcat.org/fast/1015272
subject: Mysticism
valueUri: http://id.worldcat.org/fast/1031629
subject: Occultism
valueUri: http://id.worldcat.org/fast/1043123

description: “The Mentalism magazine was published in Moscow in 1906-1908 and 1911. The publication initiative belonged to Russia's first circle of mentalists, and the editor was Nikolai Borisovich Butovt, president of the circle of mentalists, author of the book "The Complete Course of Medical Magnetism and Vitaopathy". The journal included articles, both original and translated, devoted to the popular interpretation of the occult sciences. They cover such issues as mentalism, hypnotism, personal magnetism, therapeutic magnetism, phrenology, physiognomy, graphology, chirosophy and others.” -- translated description from a Russian auction house previously selling individual copies. "These are the equivalent to scientific articles, presented as ‘factually true’ wherein authors detail phenomena, provide research narratives, methodologies, anecdotal evidence and other reflections on occultism and mystical pseudo-science. It is similar to works by Alistair Crowley in England. It also possess a degree of medical and psychological relevance as some of the articles are related to the implementation of occult science in the curing or treatment of common maladies at the time. The founder/editor/publisher was Nikolai Borisovich Butovt (1860-1936) of the first circle of mentalists. The initial pieces in each issue indicate that they had been published in Moscow in the given year. However, the bound volume was likely printed in Minsk, Belarus which at the time was part of the Russian Empire." -- Dr. Tucker D. Farris
title: Anomalous origin of left pulmonary artery from ascending aorta – A case report
Creators: name: Isamalla, Chaithanya
Publisher: name: EURORAD
Year: 2022
Subjects: subject: Cardiovascular
subject: Anatomy
subject: Cardiovascular system
subject: Contrast agents
subject: Paediatric
subject: Pulmonary vessels
subject: CT
subject: CT-Angiography
subject: Congenital
subject: Anatomy and Functional Imaging

description: Clinical History: An 18-year-old female with known history of tetralogy of fallot presented to the paediatric Outpatient department with complaints of dyspnoea. On examination, there was deep cyanosis. A2, S1 and S2 heart sounds were loud on auscultation. Echocardiography revealed ventricular septal defect and pulmonary atresia.  Hence, CT pulmonary angiogram was advised.

description: 18 year, female
Epidemiologia e filodinamica dei genotipi e sottogenotipi di HBV pi� diffusi in Italia e in Albania
Creators: name: SHKJEZI, RENATA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: The molecular epidemiology and phylodynamic history of HBV in Italy and Albania was studied on 230 Italian isolates drawn during the period 1980-2007 and 73 Albanian isolates drawn between 2005-2007 from patients living in a homogenous geographical area. Evolutionary rates were estimated and HBV demographic history was reconstructed by using a statistical approach based on coalescent theory. In Italy, the predominant genotype resulted was D (72%) followed by genotype A (20%), F and G (3%) both; among the subgenotypes, D3 was predominant in intravenous drug users (IVDUs) and A2 in men-having-sex-with-men (MSM). In Albania, the only genotype resulted was D, the predominant subgenotypes were D2 (72%), followed by D1 and D3 (14%) both. The evolutionary rates in Albanian D2 and Italian D3 subgenotype were equal. In Italy, the diffusion of D3 subgenotype was identified between 1950 and 1980 probably by use of non safely blood transfusions. In Albania, the entry and diffusion of D2 subgenotype was identified between 1986 and 1995 probably by parenteral transmission of the HBV. The exponential growth rate of D3 epidemic in Italy was significantly lower than that of D2 in Albania.
Plastic scintillation detectors for precision time-of-flight measurements of relativistic heavy ions
Creators: name: Lin, Wen-Jian
name: Zhao, Jian-Wei
name: Sun, Bao-Hua
name: He, Liu-Chun
name: Lin, Wei-Ping
name: Liu, Chuan-Ye
name: Tanihata, Isao
name: Terashima, Satoru
name: Tian, Yi
name: Wang, Feng
name: Wang, Meng
name: Zhang, Guang-Xin
name: Zhang, Xue-Heng
name: Zhu, Li-Hua
name: Duan, Li-Min
name: Hu, Rong-Jiang
name: Liu, Zhong
name: Lu, Chen-Gui
name: Ren, Pei-Pei
name: Sheng, Li-Na
name: Sun, Zhi-Yu
name: Wang, Shi-Tao
name: Wang, Tao-Feng
name: Xu, Zhi-Guo
name: Yan, Duo
name: Yue, Ke
name: Zheng, Yong
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Plastic scintillation detectors for Time-of-Flight (TOF) measurements are almost essential for event-by-event identification of relativistic rare isotopes. In this work, a pair of plastic scintillation detectors of 50 $\times$ 50 $\times$ 3$^{t}$ mm$^3$ and 80 $\times$ 100 $\times$ 3$^{t}$ mm$^3$ have been set up at the external target facility (ETF), Institute of Modern Physics. Their time, energy and position responses are measured with $^{18}$O primary beam at 400 MeV/nucleon. After the off-line walk-effect and position corrections, the time resolution of the two detectors are determined to be 27 ps ($σ$) and 36 ps ($σ$), respectively. Both detectors have nearly the same energy resolution of 3$\%$ ($σ$) and position resolution of 2 mm ($σ$). The detectors have been used successfully in nuclear reaction cross section measurements, and will be be employed for upgrading RIBLL2 beam line at IMP as well as for the high energy branch at HIAF.
description: 6 pages, 11 figures
Plain language summary for the manuscript: Bosutinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia: final 3-year follow-up results of a phase 2 study
Creators: name: Ono, Takaaki
name: Hino, Masayuki
name: Matsumura, Itaru
name: Fujisawa, Shin
name: Ishizawa, Kenichi
name: Sakaida, Emiko
name: Sekiguchi, Naohiro
name: Ono, Chiho
name: Aizawa, Mana
name: Tanetsugu, Yusuke
name: Koide, Yuichiro
name: Takahashi, Naoto
Publisher: name: Pfizer
Year: 2022
Subjects: Haematological tumours

description: This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the orignial manuscript was not involved in the preparation of this PLS and has neither reviewed not approved its content.
Issues on video on demand service policies and disk scheduling
Creators: name: Tho., Wong Wai
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Condition Monitoring of Rail Vehicle Wheel Profile
Creators: name: Melese, Gurmu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2015

description: Condition based maintenance or condition monitoring and fault detection systems are now becoming increasingly important in rail vehicles maintenance and operation, ensuring safety and reliability improvement. Up to now light rail vehicles were not the main target for this trend, because of low operation speed and lower safety factors. Nevertheless public transport operators begin to pay a closer attention to the condition monitoring of tramways, in order to reduce maintenance cost and increase safety and ride comfort for passengers, which is a very important task for public transport competitiveness in this century. To meet the above mentioned goal, this paper models rail-wheel condition monitoring program based on rail vehicle wheel profile analysis by using mathematical analysis and matlab simulation to extract different features. By extracting different features and using matlab simulation, it obtained graphical indication for monitoring of the wheel condition by setting expected goal. So it can be applied in any types of rail vehicles because it reduces maintenance cost and increase safety factors. Good or bad wheel profile can easily be identified by using such matlab algorithm for specified rail vehicles. Therefore, this paper focuses on identification of proper wheel profile for any types of rail vehicles. Moreover, other monitoring system such as vibration, sound and etc can also be applied by using such algorithm.