cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanical Properties Investigation of Additive Manufactured Ti-6Al-4V Cellular Structure
Creators: name: Alnaser, Husain
Publisher: name: University of Utah
Year: 2019
Subjects: Materials science

description: Ti-6Al-4V is an alloy that has been developed to be used in medical implants due to its compatibility with the human body. Additive manufacturing technology has also become useful in constructing human bone design (marrow) from Ti-6Al-4V, imitating bone function. This research focuses on studying mechanical properties of Ti-6Al-4V using powder laser bed fusion (PLBF). This thesis describes the lattice structure for Ti-6Al-4V and discusses the design and the properties of the material based on tensile testing and other tests. This thesis focuses on understanding the mechanical properties of Ti-6Al-4V by presenting a literature review and comparing the structural strengths of the lattice and the full solid. Then, the research examines the powder comprising the fabricated specimen, the design that was chosen, and the parameters that affect the design mechanical properties in the results. Also, part of the discussion discusses heat affected zones (HAZ) comparing welding to additive manufacturing (AM) as a micro-weld. This section reveals some of the answers about the variability of mechanical properties in AM technologies, especially in PLBF. Lastly, microstructure images and CT scan images were analyzed through Image J. The image processing helps relate theoretical data and experimental results to quantitative data acquired from image processing. After compiling the analyses from the various sources, a design model was created to enhance the investigation of mechanical properties by giving visual evidence to support the conclusions.
Mechanistic Studies of Ligand Controlled Selectivity in Gold and Palladium Catalyzed Reactions
Creators: name: Niemeyer, Zachary Louis
Publisher: name: University of Utah
Year: 2019
Subjects: Chemistry

description: Linear free energy relationships have been a staple of reaction mechanistic studies for nearly 100 years, enabling the quantification of subtle steric and electronic interactions between ligand, catalyst, and substrate. Recent work has offered an integrated approach to both interrogate reaction selectivity origins and to predict more optimal conditions. Classic and modern approaches to analyze ligand effects are presented in Chapter 1. Chapter 2 focuses on the development of novel descriptors for monodentate phosphine ligands. The application of these parameters to a Suzuki reaction was complicated by multiple ligation states of the catalyst. Experimental outcomes indicated that two catalyst regimes are present in the reaction; thus, separation of the results into subclasses was necessary. Doing so simplified the selectivity models, revealing nuanced ligand effects that were quantified with the new parameters. Further applications of these phosphine descriptors are detailed in Chapter 3. First, two gold-phosphine catalyzed cycloisomerization reactions are investigated using physical organic techniques along with reaction selectivity correlations. Overall, these data are used to identify the origin of ligand induced chemoselectivity, and to predict a novel ligand to increase the desired product ratio. Second, studies of an alkyl-aryl Suzuki reaction are described. In this instance, the phosphine ligand is shown to affect the enantiospecificity and chemoselectivity in two different fundamental steps. Evidence of the role ligand size and electronics play in directing the reaction pathways are presented. Chapter 4 details our team's efforts to identify a catalyst system that favors the atypical oxidative addition pathway within a Buchwald-Hartwig coupling reaction of differentially halogenated hetero-aromatics. Bidentate phosphine ligands were found to induce moderate selectivity; thus, ligand parameterization was utilized. Guided by univariate correlations, an exceedingly selective diaminophosphine ligand was successfully predicted, the origins of which were additionally analyzed with density functional theory (DFT) calculations. Using similar multivariate techniques, Chapter 5 presents the parameterization of acyclic diaminocarbene ligands developed in the context of a gold-catalyzed rearrangement-cyclization reaction. Enantioselectivity in this case was found to be highly sensitive to two substituents on the ligand, and quantification of these effects enabled the identification of a reaction system that produces highly enantioenriched products.
Boletín Fármacos: Prescripción, Farmacia y Utilización 2024; 27(1)
Creators: name: Salud y Fármacos
Publisher: name: Salud y Fármacos
Year: 2024
Subjects: Prescripción
Farmacia
Utilización
Distribución
Uso adecuado de medicamentos
Covid
Innovación
Resistencia antimicrobiana
Cannabis medicinal
Salud de la mujer y los niños
Salud mental
Oncología
Farmacia y Dispensación

description: Boletín Fármacos es un boletín electrónico de la organización Salud y Fármacos (https://www.saludyfarmacos.org/) que se publica cuatro veces al año: febrero, mayo, agosto y noviembre.

El Boletín Fármacos: Prescripción, Farmacia y Utilización informa sobre el rol que diferentes actores (prescriptor, distribuidor, farmacéutico y paciente) y actividades (prescripción, distribución, dispensación y utilización) tienen en el uso adecuado de medicamentos, e incluye recomendaciones para mejorar estos procesos. El volumen incluye las secciones de Prescripción, Farmacia y Distribución, y Utilización. En la sección de Utilización se incluye información sobre como la producción, el consumo o la mala disposición de los remanentes de medicamentos, tanto de consumo humano como en agropecuaria, contamina en el medio ambiente.

Este documento corresponde al 2024, Vol. 27, N°1.
Additional file 1: of Health behaviour changes in partners of women with recent gestational diabetes: a phase IIa trial
Creators: name: Anne-Sophie Brazeau
name: Meltzer, Sara
name: Pace, Romina
name: Garfield, Natasha
name: Godbout, Ariane
name: Meissner, Leslie
name: Rahme, Elham
name: Costa, Deborah Da
name: Kaberi Dasgupta
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Table S1. Change in food intakes and eating behaviors. MEQ: Mindful eating questionnaire; Score out of 4; Higher values = more mindfulness WEL: Weight efficacy lifestyle questionnaire; Score out of 9; Higher values = higher self-efficacy. Table S2. Change in physical activity behaviors. PASP-Q: Physical activity and sedentary behaviour questionnaire; MVPA: Moderate to vigorous physical activity; OSPAQ: Occupational Sitting And Physical Activity Questionnaire. Table S3. Change in cardiometabolic parameters among the MoMM and MoMM-ii mothers. BMI: Body mass index; HOMA-IR: Homeostasis model-assessment-estimated insulin resistance. (DOCX 51 kb)
A comparison of classical interatomic potentials applied to highly concentrated aqueous lithium chloride solutions
Creators: name: Pethes, Ildikó
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Aqueous lithium chloride solutions up to very high concentrations were investigated in classical molecular dynamics simulations. Various force fields based on the 12-6 Lennard-Jones model, parametrized for non-polarizable water solvent molecules (SPC/E, TIP4P, TIP4PEw), were inspected. Twenty-nine combinations of ion-water interaction models were examined at four different salt concentrations. Densities, static dielectric constants and self-diffusion coefficients were calculated. Results derived from the different force fields scatter over a wide range of values. Neutron and X-ray weighted structure factors were also calculated from the radial distribution functions and compared with experimental data. It was found that the agreement between calculated and experimental curves is rather poor for several investigated potential models, even though some of them have previously been applied in computer simulations. None of the investigated models yield satisfactory results for all the tested quantities. Only two parameter sets provide acceptable predictions for the structure of highly concentrated aqueous LiCl solutions. Some approaches for adjusting potential parameters, such as those of Aragones [Aragones et al., J. Phys. Chem. B 118 (2014) 7680] and Pluharova [Pluharova et al, J. Phys. Chem. A 117 (2013) 11766], were tested as well; the simulations presented here underline their usefulness. These refining methods are suited to obtain more appropriate ion/water potentials.
description: 65 pages together with Supplementary informations, submitted to J.Mol.Liq
Methods for the Improved Detection of Tuberculosis Biomarkers with an Emphasis Towards Point-of-Need Diagnostics
Creators: name: Owens, Nicholas Andrew
Publisher: name: University of Utah
Year: 2019
Subjects: Bioengineering
Analytical chemistry
Biomedical engineering

description: The effective diagnosis of infectious diseases, like tuberculosis (TB), through the detection of biomarkers indicative of active infection, continues to challenge the scientific community. Due to the consistently high burden of disease in low-income economies, there has been a renewed interest to transition the capabilities of the diagnostic tests from the research laboratory to point-of-need (PON) applications. To identify the characteristics of these PON tests, the World Health Organization has established the ASSURED ( affordable, sensitive, specific, user-friendly, rapid, equipment-free, and delivered to those in need) guidelines. Using the detection of mannose-capped lipoarabinomannan (ManLAM), a TB biomarker, as a model system, the research presented herein focuses on approaches to meet the challenges faced by modern infectious disease diagnostics with an emphasis on transitioning state-of-the-art surface-enhanced Raman scattering (SERS) immunoassays toward PON applications within the framework of the ASSURED guidelines. First, we build on previous work investigating the underpinnings of an acid treatment method to improve the detection of ManLAM in the serum of infected individuals. This work demonstrates that while acid treatment improves the detection of ManLAM, assay performance is hindered because of the acid-induced degradation of ManLAM and the incomplete decomplexation of endogenous serum proteins. Through the application of an enzymatic sample treatment process, this work also shows that improved ManLAM recoveries lead to improved clinical accuracies. To increase assay performance, we developed, charactered, and validated a novel surface-enhanced resonance Raman scattering (SERRS) immunoassay. This improves the limit of detection (∼10x) and analytical sensitivity (∼39x) for ManLAM measurements compared to an analogous SERS immunoassay. The remainder of the work validates the use of a handheld Raman spectrometer for the detection of phospho-myo-inositol-capped LAM (PILAM), a ManLAM simulant. This work demonstrates the ability to achieve low limits of detection (∼0.2 ng/mL) for PILAM in human serum and document the impact of excitation wavelength and the plasmonic coupling between the labels and planar gold substrates as a basis for further improvements in SERS immunoassays. Taken together, this work begins to establish approaches for improved methodologies to combat the burden of infectious diseases, and to demonstrate the applicability of SERS detection beyond the research laboratory.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Cart. 189 (11 H 74), 316 folios, f. 0185r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0185r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0185r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Metabolic Regulation at the Intersection of Genes and Environment
Creators: name: Palu, Rebecca Anne Somer
Publisher: name: University of Utah
Year: 2019

description: The incidence of complex metabolic disease has risen to an alarming level in the last several decades. This elevated frequency has been accompanied by increased social and financial costs, with nearly $250 billion spent each year on diabetes alone. Despite this growing health crisis, only a small percentage of the heritable risk for these disorders has been identified. Possible sources of this missing heritability include geneenvironment interactions and gene-gene interactions, as well as the influence of parental or grandparental metabolism. In this work, I have focused on characterizing potential sources of these effects and the impacts they may have on physiology. The deacetylase Sir2 is a conserved metabolic regulator whose influence in normal and pathological physiology has been well documented but little understood. In characterizing Drosophila sir2 mutants, I discovered that loss of sir2 leads to progressive defects in carbohydrate and lipid homeostasis as well as the development of insulin resistance and glucose intolerance. I found that these functions of Sir2 are localized to the fat body and partially restore metabolic function by overexpressing the nuclear receptor dHNF4. Finally, I found that dHNF4 acetylation and stability is altered in sir2 mutants, suggesting that this factor is a key and direct target for Sir2 in the maintenance of metabolic flexibility. In the second part of this work, I focus on the development of both dietary and genetic paradigms to induce metabolic dysfunction in the parental generation that can iv lead to heritable physiological defects in their progeny. I found that either method of altering parental metabolic state can induce heritable changes in offspring metabolism under both basal and challenge conditions for at least two generations. I also identified key sources of genetic and environmental variation that influence the degree of parental dysfunction as well as the degree of physiological responses in the progeny. These studies lay the groundwork for more careful characterization of progeny responses, the molecular pathways affected in these progeny, as well as the mechanisms by which these changes are inherited.
Additional file 7: of Bidirectional promoters exhibit characteristic chromatin modification signature associated with transcription elongation in both sense and antisense directions
Creators: name: Jangid, Rahul
name: Ashwin Kelkar
name: Vijaykumar Muley
name: Galande, Sanjeev
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S7. H3K79me1 distribution on bidirectional gene with different intergenic region in H1 ES cells. The figure shows enrichment of H3K79me1 at the bidirectional genes pairs with intergenic distance up to 1000 bp. Intergenic distance is represented as the number of nucleosomes that could potentially be accommodated. Data are shown for the gene pairs which have intergenic region that could contain 2 to 6 nucleosomes assuming 170 bp length for wrapping around each octamer and inclusive of 20 bp linker. Cumulative expression is calculated by summation of fold enrichment signal at every location in a 4 KB window for each category and dividing by the highest value of signal in the respective category as described in ‘Methods’. (A) Cumulative enrichment of H3K79me1 on bidirectional genes which are asymmetric with respect to their expression profiles. (B) Cumulative enrichment of H3K79me1 on bidirectional genes which are symmetric with respect to their expression profiles. (PDF 831 kb)
Dynamical effects of the scale invariance of the empty space: The fall of dark matter ?
Creators: name: Maeder, Andre
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The hypothesis of the scale invariance of the macroscopic empty space, which intervenes through the cosmological constant, has led to new cosmological models. They show an accelerated cosmic expansion and satisfy several major cosmological tests. No unknown particles are needed. Developing the weak field approximation, we find that the here derived equation of motion corresponding to Newton's equation also contains a small outwards acceleration term. The new term is particularly significant for very low density systems. A modified virial theorem is derived and applied to clusters of galaxies. For the Coma and Abell 2029 clusters, the dynamical masses are about a factor of 5 to 10 smaller than in the standard case. This tends to let no room for dark matter in these clusters. Then, the two-body problem is studied and an equation corresponding to the Binet equation is obtained. The results are applied to the rotation curve of the outer layers of the Milky Way. Starting backwards from the present rotation curve, we calculate the past evolution of the galactic rotation and find that, in the early stages, it was steep and Keplerian. Thus, the flat rotation curves of galaxies appears as an age effect, a result consistent with recent observations of distant galaxies by Genzel et al. (2017) and Lang et al. (2017). Finally, in an Appendix we also study the long-standing problem of the increase with age of the vertical velocity dispersion in the Galaxy. The observed increase appears to result from the new small acceleration term in the equation of the harmonic oscillator describing stellar motions around the galactic plane. Thus, we tend to conclude that neither the dark energy, nor the dark matter seem to be needed in the proposed theoretical context.
description: 20 pages, 4 figures
Micrornas and Type I Interferon are Critical Immune Modulators in Lyme Arthritis
Creators: name: Lochhead, Robert Bruce Jr.
Publisher: name: University of Utah
Year: 2019

description: Lyme arthritis is the result of dysregulated immune response to infection by Borrelia burgdorferi, a tick-borne spirochete. Several immune modulators have been shown to be important to host defense and Lyme arthritis susceptibility, including toll- like receptor signaling, NF-kB activation, and various cytokines and chemokines, including type I IFN. Here we show that type I IFN and microRNAs play critical roles in modulating Lyme arthritis development. C3H mice exhibit an early, preclinical upregulation of type I IFN-responsive genes, which is associated with increased arthritis severity. Using C3H IFNAR -/- knockout mice, we showed that C3H mice lacking type I IFN signaling have a partial reduction in arthritis severity. Radiation chimeras showed that IFN signaling in both radiation sensitive and radiation resistant cells within the joint are required for maximal arthritis. Ex vivo cell sorting of cells isolated from joint tissue also showed that hematopoietic cells were the only cell types capable of initiating a type I IFN response after stimulation with B. burgdorferi, but both hematopoietic and resident cells were involved in amplification of the type I IFN response. Endothelial cells and fibroblasts were also major producers of IFN-responsive genes and inflammatory cytokines. MicroRNAs have been shown to be important immune regulators, and have been associated with several inflammatory diseases, including rheumatoid arthritis and lupus. Here we show that several microRNAs were differentially expressed in B6, C3H, and B6 IL10-/- mice infected with B. burgdorferi. MicroRNA-146a, a repressor of TLR signaling and NF-κB activation, was upregulated in all three strains, suggesting it plays an important role in the immune response to infection. B6 miR-146a-/- mice infected with B. burgdorferi developed more severe arthritis, had elevated myeloid infiltration, upregulation of inflammatory cytokines, and had fewer numbers of bacteria in joint tissue at 4 weeks postinfection, indicating that miR-146a-mediated regulation of NF-κB activation modulated immune response and arthritis development. Similar patterns of dysregulation were observed in B6 miR-146a -/- macrophages, which produced excessive cytokines, exhibited increased phagocytosis, and had elevated protein levels of TRAF6. Together, these data show that miR-146a is a critical regulator of NF-κB activation and arthritis development during infection with B. burgdorferi.
Jet Properties from Dihadron Correlations in p+p Collisions at sqrt(s)=200 GeV
Creators: name: PHENIX Collaboration
name: Adler, S. S.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The properties of jets produced in p+p collisions at sqrt(s)=200 GeV are measured using the method of two particle correlations. The trigger particle is a leading particle from a large transverse momentum jet while the associated particle comes from either the same jet or the away-side jet. Analysis of the angular width of the near-side peak in the correlation function determines the jet fragmentation transverse momentum j_T . The extracted value, sqrt()= 585 +/- 6(stat) +/- 15(sys) MeV/c, is constant with respect to the trigger particle transverse momentum, and comparable to the previous lower sqrt(s) measurements. The width of the away-side peak is shown to be a convolution of j_T with the fragmentation variable, z, and the partonic transverse momentum, k_T . The is determined through a combined analysis of the measured pi^0 inclusive and associated spectra using jet fragmentation functions measured in e^+e^-. collisions. The final extracted values of k_T are then determined to also be independent of the trigger particle transverse momentum, over the range measured, with value of sqrt() = 2.68 +/- 0.07(stat) +/- 0.34(sys) GeV/c.
description: 330 authors, 27 pages, 31 figures, 12 tables. Submitted to Physical Review D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
Mechanisms of genome degeneration and adaptation in symbiosis
Creators: name: Clayton, Adam Larsen
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Molecular biology
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology

description: Intracellular mutualistic endosymbionts are widespread among insect species and perform many different functions for their hosts. While the role of each symbiont varies among hosts, the evolution of symbiont genomes follows a similar degenerative trajectory. Genome degeneration is a consequence of relaxed selection on gene functions no longer required in the symbiotic relationship. Previous efforts to understand the forces shaping symbiont genomes have involved comparing long established symbionts with distantly related free-living bacteria. In order to characterize the mechanisms driving symbiont genome degeneration, recently established symbionts must be compared with closely related free-living relatives. This work describes the discovery of a non host-associated member of the Sodalis-allied clade of insect symbionts, Sodalis praecaptivus str. HS1. Whole genome comparisons between S. praecaptivus and the recently established symbionts, Sodalis glossinidius and Candidatus Sodalis pierantonius show that these symbionts evolved independently from an S. praecaptivus-like ancestor. Detailed genomic comparisons between S. praecaptivus and Ca. S. pierantonius reveal that insertions and deletions resulting from replication slippage errors associated with G+C-rich repeat sequences are an important driver of gene inactivation and deletion in the early stages of symbiosis. This slippage-prone phenotype is mechanistically associated with the loss of certain components of the bacterial DNA recombination machinery at an early stage in symbiotic life and is expected to facilitate rapid adaptation to the novel host environment. This work also includes a comparative analysis of the PhoP-PhoQ two-component systems of S. praecaptivus and S. glossinidius, which is involved in mediating resistance to antimicrobial peptides produced by the host immune system. Comparative transcriptomics identifies significant differences in the PhoP regulatory networks of these closely related organisms. This work also describes the discovery of a novel transcriptional regulator involved in resistance to antimicrobial peptides. The role of genome degeneration as it relates to bacterial adaptation in novel environments is also explored. Using a library of transposon Tn 5 mutants of S. praecaptivus this work shows that the inactivation of various genes, many of which are global transcriptional regulators, can provide significant fitness advantages in novel environments, including an insect host. This rapid adaptation is thought to occur by disrupting established regulatory networks allowing existing genes and metabolic pathways to be reconfigured in ways that are better suited to the novel environments encountered by the cell.
MPEC 2024-D128 : 2017 SF19
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Methylation and Somoylation Regulate LSD1-Corest Recruitment and Activity to Control Transciptional and Cellular Functions of GFI1
Creators: name: Velinder, Matthew Edward
Publisher: name: University of Utah
Year: 2019

description: Proper cell fate decisions require precise and coordinated changes in gene expression. Alterations in gene expression proceed through the functions of transcription factors, their associated coregulators and histone modifying enzymes. However, how these complex and diverse groups of proteins and enzymes coordinate their respective functions at target genes remains largely unknown. To gain additional insights into the coordinated activities of transcription factors and histone modifying enzymes, we studied how the transcription factor growth factor independence 1 (GFI1) carries out transcriptional repression through interaction with coregulator histone modifying enzymes. GFI1 is a transcriptional repressor and master regulator of normal and malignant hematopoiesis. GFI1 is comprised of a transcriptionally repressive N-terminal Snail/Slug/GFI1 (SNAG) domain, a C-terminal concatemer of DNA binding zinc fingers and a linker region which separates them. The relatively simple protein domain structure of GFI1 makes it an ideal transcription factor for studying mechanisms of transcriptional repression. We describe here two novel mechanisms of transcriptional repression by GFI1, both of which occur through posttranslational modification. First, we identify and characterize a SUMOylation event carried out by the SUMO2/3, UBC9, and PIAS3 SUMOylation machinery. SUMOylation occurs at K239 within a type I SUMO consensus element in the linker region of GFI1. We find that SUMO iv defective GFI1 derivatives fail to complement Gfi1 depletion phenotypes in zebrafish developmental erythropoiesis and in granulocyte differentiation in cultured human cells. SUMO defective GFI1 derivatives also display impaired LSD1/CoREST binding and fail to repress the GFI1 target gene MYC during granulocyte differentiation and enforced MYC expression blocks GFI1 mediated granulocyte differentiation. Second, we show SMYD2 mediated methylation at K8 within the GFI1 SNAG domain is a critical determinant of GFI1 transcriptional repression and contributes to GFI1 hematopoietic differentiation and leukemia cell survival functions. The methylation defective GFI1 SNAG domain lacks repressor function due to a failure of LSD1 recruitment and accumulation of promoter H3K4 dimethyl marks. Our findings here suggest GFI1 SUMOylation and methylation are part of a series of regulatory inputs that regulate GFI1 function. From these data we propose SNAG domain methylation and linker region SUMOylation coordinate LSD1/CoREST recruitment and enable CoREST dependent activation of LSD1 H3K4 demethylase activity for repression of GFI1 target genes. Our findings add GFI1 to the growing roster of transcription factors regulated by posttranslational modification and provides a rare mechanistic understanding into how these modifications regulate transcription factor functions through the recruitment histone modifying enzyme effectors.
Metagenomic Approach to Study Innovative Nitrogen Transformations in Natural Ecosystems
Creators: name: Bhattacharjee, Ananda Shankar
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Engineering
subject: Environmental engineering
subject: FOS: Environmental engineering

description: The global nitrogen cycle was essentially considered 'linear' as it is straightforward from the atmosphere and back again. However, discoveries of additional pathways suggested that there is still much to be learned about the nitrogen cycling, the organisms responsible, and their interactions in natural and anthropogenic ecosystems. In this research two novel innovative nitrogen transformation pathways - (a) nitrite-dependent denitrification coupled with anaerobic methane oxidation (n-DAMO) and (b) anaerobic ammonium oxidation (Anammox) - investigated to unravel the diversity and contributions of micro-organisms. The roles of aerobic (AOM) and anaerobic methane-oxidizing (n-DAMO) organisms coupled with denitrification were evaluated in (a) wetlands and (b) riverine sediments. AOM coupled with denitrification (nitrate-dependent) contributed to 9.8-7.3 and 4.5-3.5% oxidation of methane produced in wetlands and riverine ecosystems, respectively. Contributions of the n-DAMO process were also estimated, and it was more prominent in riverine sediments. Subsequently, riverine sediments were investigated for the microbial diversity using 'omics'. A laboratory-scale reactor enriched n-DAMO prokaryotes from riverine sediments. 'Omics' data and anaerobic methane oxidation rates confirmed plausible enrichment of n-DAMO prokaryotes. The plausibility to use n-DAMO prokaryotes for engineered ecosystems was investigated. After 19 months of n-DAMO reactor operation, nitrite removal rate of 2.88mmol L-1 d-1 was achieved. The increased enrichment was evident from higher 16SrRNA gene copy numbers and CH4 oxidation rates coupled with NO2- -N removal (21μM to 190μM of CH4 d-1). Novel primers targeting the unique nitric oxide dismutase (nod) gene were developed and tested. Phylogenetic analysis revealed that enriched n-DAMO organisms related to the Ca' Methylomirabilis oxyfera. The complex community existing in Anammox bioreactors were examined in two laboratory-scale reactors: (a) suspended (SGR) and (b) attached (AGR) growth. In a period of 220 days, both bioreactors achieved comparable rates in total inorganic nitrogen (TIN) removal of 88±4% and 86±2%. The investigation of the community-structure using 'omics' revealed Anammox sp. was related to Ca' B. sinica sp. with the dominant flanking community comprising of Anaerolinea, Ignavibacterium, and Rhodocyclaceae sp. Genome analysis of Anammox bacterial sp. extracted from SGR and AGR metagenome revealed species could be placed under genera Ca' Brocardia, expanding Anammox diversity.
Metallicity Effects on Mid-Infrared Colors and the 8 micron PAH Emission in Galaxies
Creators: name: Engelbracht, C. W.
name: Gordon, K. D.
name: Rieke, G. H.
name: Werner, M. W.
name: Dale, D. A.
name: Latter, W. B.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We examine colors from 3.6 micron to 24 micron as a function of metallicity (O/H) for a sample of 34 galaxies. The galaxies range over 2 orders of magnitude in metallicity. They display an abrupt shift in the 8 micron to 24 micron color between metallicities 1/3 to 1/5 of the solar value. The mean 8 micron to 24 micron flux density ratio below and above 12 + log (O/H) = 8.2 is 0.08 +/- 0.04 and 0.70 +/- 0.53, respectively. We use mid-infrared colors and spectroscopy to demonstrate that the shift is primarily due to a decrease in the 8 micron flux density as opposed to an increase in the 24 micron flux density. This result is most simply interpreted as due to a weakening at low metallicity of the mid-infrared emission bands usually attributed to PAHs (polycyclic aromatic hydrocarbons) relative to the small-grain dust emission. However, existing empirical spectral energy distribution models cannot account for the observed short-wavelength (i.e., below 8 micron) colors of the low-metallicity galaxies merely by reducing the strength of the PAH features; some other emission source (e.g., hot dust) is required.
description: accepted to ApJ Letters
Investigating the origin of cyclical wind variability in hot, massive stars - II. Hydrodynamical simulations of co-rotating interaction regions using realistic spot parameters for the O giant $ξ$ Persei
Creators: name: David-Uraz, A.
name: Owocki, S. P.
name: Wade, G. A.
name: Sundqvist, J. O.
name: Kee, N. D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: OB stars exhibit various types of spectral variability historically associated with wind structures, including the apparently ubiquitous discrete absorption components (DACs). These features have been proposed to be caused either by magnetic fields or non-radial pulsations. In this second paper of this series, we revisit the canonical phenomenological hydrodynamical modelling used to explain the formation of DACs by taking into account modern observations and more realistic theoretical predictions. Using constraints on putative bright spots located on the surface of the O giant $ξ$ Persei derived from high precision space-based broadband optical photometry obtained with the Microvariability and Oscillations of STars (MOST) space telescope, we generate two-dimensional hydrodynamical simulations of co-rotating interaction regions in its wind. We then compute synthetic ultraviolet (UV) resonance line profiles using Sobolev Exact Integration and compare them with historical timeseries obtained by the International Ultraviolet Explorer (IUE) to evaluate if the observed behaviour of $ξ$ Persei's DACs is reproduced. Testing three different models of spot size and strength, we find that the classical pattern of variability can be successfully reproduced for two of them: the model with the smallest spots yields absorption features that are incompatible with observations. Furthermore, we test the effect of the radial dependence of ionization levels on line driving, but cannot conclusively assess the importance of this factor. In conclusion, this study self-consistently links optical photometry and UV spectroscopy, paving the way to a better understanding of cyclical wind variability in massive stars in the context of the bright spot paradigm.
description: 16 pages, 10 figures, accepted for publication by MNRAS
Suppressing decoherence of quantum algorithms by jump codes
Creators: name: Kern, Oliver
name: Alber, Gernot
Publisher: name: arXiv
Year: 2005
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The stabilizing properties of one-error correcting jump codes are explored under realistic non-ideal conditions. For this purpose the quantum algorithm of the tent-map is decomposed into a universal set of Hamiltonian quantum gates which ensure perfect correction of spontaneous decay processes under ideal circumstances even if they occur during a gate operation. An entanglement gate is presented which is capable of entangling any two logical qubits of different one-error correcting code spaces. With the help of this gate simultaneous spontaneous decay processes affecting physical qubits of different code spaces can be corrected and decoherence can be suppressed significantly.
On the Case for a Super Tau-Charm Factory
Creators: name: Asner, David M.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Design studies for a Super Flavor Factory (SFF), an asymmetric energy e+e- collider utilizing International Linear Collider (ILC) techniques and technology, are in progress. The capablity to run at center-of-mass energies near 3.770 GeV could be included in the initial design. This report discusses the physics that can be probed with luminosity of 10^{35} 1/cm^2 1/s near tau-charm threshold.
description: 15 pages, Contributed to the International Workshop on Discoveries in Flavour Physics at e+e- Colliders (DIF 06), Frascati, Italy, 28 Feb - 3 Mar, 2006
The Birthplace of Low-Mass X-ray Binaries: Field Versus Globular Cluster Populations
Creators: name: Irwin, Jimmy A.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent Chandra studies of low-mass X-ray binaries (LMXBs) within early-type galaxies have found that LMXBs are commonly located within globular clusters of the galaxies. However, whether all LMXBs are formed within globular clusters has remained an open question. If all LMXBs formed within globular clusters, the summed X-ray luminosity of the LMXBs in a galaxy should be directly proportional to the number of globular clusters in the galaxy regardless of where the LMXBs currently reside. We have compared these two quantities over the same angular area for a sample of 12 elliptical and S0 galaxies observed with Chandra and found that the correlation between the two quantities is weaker than expected if all LMXBs formed within globular clusters. This indicates that a significant number of the LMXBs were formed in the field, and naturally accounts for the spread in field-to-cluster fractions of LMXBs from galaxy to galaxy. We also find that the "pollution" of globular cluster LMXBs into the field has been minimal within elliptical galaxies, but there is evidence that roughly half of the LMXBs originally in the globular clusters of S0 galaxies in our sample have escaped into the field. This is due to higher globular cluster disruption rates in S0s resulting from stronger gravitational shocks caused by the passage of globular clusters through the disks of S0 galaxies that are absent in elliptical galaxies.
description: To appear in ApJ, 1 October 2005, v631 2 issue, 9 pages, 3 figures, typos and a few minor issues corrected
MOESM1 of An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer
Creators: name: Fort, Rafael
name: Mathó, Cecilia
name: Oliveira-Rizzo, Carolina
name: Garat, Beatriz
name: Sotelo-Silveira, José
name: Duhagon, María
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Additional file 1: Figure S1. Detailed genomic view of the miR-130b/301b gene cluster region in UCSC Genome browser (GRCh37/hg19). Several ENCODE tracks are displayed.
title: High School–University Collaborations for Latinx Student Success: Navigating the Political Reality
Creators: name: Bettencourt, Genia
name: George Mwangi, Chrystal A.
name: Green, Keisha
name: Morales Morales, Daniel
Publisher: name: University of Massachusetts Amherst
Year: 2020
Subjects: subject: Latinx youth
subject: career and technical education
subject: high school-university partnerships
subject: LatCrit
subject: Higher Education

description: Latinx students are a growing population in postsecondary education but attain degrees at a pace behind their non-Latinx peers. This research examines a partnership between a research university (RU) and career and technical education (CTE) high school, Hillside Technical High School (HTHS). Through a 2-year ethnographic case study, we found that different logistics and cultural values were primary contributors to the bifurcated pathway between high school and college. These pathways were most successfully connected through strategies such as flexibility, personal relationships, and incorporation of community resources as well as viewing the students as resources. Our study suggests a need to reframe partnerships in recognition of the assets that students bring to these e orts, while also creating opportunities for additional faculty support and community involvement.
[Muy estimado Sr. Cortázar: Le agradezco su carta del 31 de julio y espero que su estadía en Nicaragua]
Creators: name: Laura, Gutiérrez-Witt
name: Gutiérrez-Witt, Laura
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Venta manuscritos de Cortázar

description: Carta de la Directora de la Benson Latin American Collection (Universidad de Texas en Austin). El nuevo presupuesto le permite comprar el manuscrito de "Rayuela" con el precio convenido. Puede enviar la obra con la factura.
description: Source: Num.Ref. : JC-DY-CAR-01.014
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
D4.3- Report on results of the capacity building workshop
Creators: name: García Alegre, María
name: Duenas-Sanchez, Rafael
Publisher: name: Zenodo
Year: 2024

description: This document is the outcome of BIObec project related to the Report on results of the capacity building workshop (contract no. 101023381) corresponding to D4.3 (M30) led by CTA. This document contains the summary of the activities conducted and the results of the workshop collected through Task 4.3.
On Upper Approximations of Pareto Fronts
Creators: name: Kaliszewski, Ignacy
name: Miroforidis, Janusz
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90

description: In one of our earlier works, we proposed to approximate Pareto fronts to multiobjective optimization problems by two-sided approximations, one from inside and another from outside of the feasible objective set, called, respectively, lower shell and upper shell. We worked there under the assumption that for a given problem an upper shell exists. As it is not always the case, in this paper we give some sufficient conditions for the existence of upper shells. We also investigate how to constructively search infeasible sets to derive upper shells. We approach this issue by means of problem relaxations. We formally show that under certain conditions some subsets of lower shells to relaxed multiobjective optimization problems are upper shells in the respective unrelaxed problems. Results presented are illustrated by a numerical example representing a~small but real mechanical problem. Practical implications of the results are discussed.
description: 31 pages, 9 figures, 33 references
Controlling quantum systems by embedded dynamical decoupling schemes
Creators: name: Kern, Oliver
name: Alber, Gernot
Publisher: name: arXiv
Year: 2005
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A dynamical decoupling method is presented which is based on embedding a deterministic decoupling scheme into a stochastic one. This way it is possible to combine the advantages of both methods and to increase the suppression of undesired perturbations of quantum systems significantly even for long interaction times. As a first application the stabilization of a quantum memory is discussed which is perturbed by one-and two-qubit interactions.
Additional file 6: of Bidirectional promoters exhibit characteristic chromatin modification signature associated with transcription elongation in both sense and antisense directions
Creators: name: Jangid, Rahul
name: Ashwin Kelkar
name: Vijaykumar Muley
name: Galande, Sanjeev
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S6. H3K27ac distribution on bidirectional gene with different intergenic region in CD4 T cells. The figure shows enrichment of H3K27ac at the bidirectional genes pairs with intergenic distance up to 1000 bp. Intergenic distance is represented as the number of nucleosomes that could potentially be accommodated. Data are shown for the gene pairs which have intergenic region that could contain 2 to 6 nucleosomes assuming 170 bp length for wrapping around each octamer and inclusive of 20 bp linker. Cumulative expression is calculated by summation of fold enrichment signal at every location in a 4 Kb window for each category and dividing by the highest value of signal in the respective category as described in ‘Methods’. (A) Cumulative enrichment of H3K27ac on bidirectional genes which are asymmetric with respect to their expression profiles. (B) Cumulative enrichment of H3K27ac on bidirectional genes which are symmetric with respect to their expression profiles. (PDF 819 kb)