cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Coplas nuevas en alabanza de María santísima de la Aurora: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake
Creators: name: Zubaida Saifudeen
name: El-Dahr, Samir S.
name: Kopkan, Libor
name: Husková, Zuzana
name: Šárka Jíchová
name: Červenková, Lenka
name: Luděk Červenka
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: We elucidated the role of collecting duct kinin B2 receptor (B2R) in the development of salt-sensitivity and angiotensin II (ANG II)-induced hypertension. To this end, we used a Cre-Lox recombination strategy to generate mice lacking Bdkrb2 gene for B2R in the collecting duct (Hoxb7-Cretg/+:Bdkrb2flox/flox). In 3 groups of control (Bdkrb2flox/flox) and 3 groups of UBBdkrb2−/− mice, systolic blood pressure (SBP) responses to high salt intake (4 or 8% NaCl; HS) were monitored by radiotelemetry in comparison with standard salt diet (0.4% NaCl) prior to and during subcutaneous ANG II infusion (1000 ng/min/kg) via osmotic minipumps. High salt intakes alone for 2 weeks did not alter SBP in either strain. ANG II significantly increased SBP equally in control (121 ± 2 to 156 ± 3 mmHg) and UBBdkrb2−/− mice (120 ± 2 to 153 ± 2 mmHg). The development of ANG II-induced hypertension was exacerbated by 4%HS in both control (125 ± 3 to 164 ± 5 mmHg) and UBBdkrb2−/− mice (124 ± 2 to 162 ± 3 mmHg) during 2 weeks. Interestingly, 8%HS caused a more profound and earlier ANG II-induced hypertension in UBBdkrb2−/− (129 ± 2 to 166 ± 3 mmHg) as compared to control (128 ± 2 to 158 ± 2 mmHg) and it was accompanied by body weight loss and increased mortality. In conclusion, targeted inactivation of B2R in the renal collecting duct does not cause salt-sensitivity; however, collecting duct B2R attenuates the hypertensive actions of ANG II under conditions of very high salt intake.
ANALYSIS OF WASTEWATER CONTENT IN THE SOAP INDUSTRY
Creators: name: Sanjarbek Xusinbay Ugli Shamuratov
name: Umarbek Kadirberganovich Alimov
name: Adamov, Anvar Nurullayevich
name: Kamilovna Saparbaeva Nasiba
name: Muborak Saparbaevna Xusainova
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Soap stock
crude fat acid
alkali
acid waste water

description: The issues of environmental protection, including wastewater treatment, are of great importance for the functioning of soap production. Soap production generates waste that must be treated before being dumped into the sewer. An important component of soap are alkalis, mainly sodium (in the production of solid soaps) and potassium (in the production of liquid and ointment soaps). Salts of alkaline earth and heavy metals in the composition of household soaps: are a harmful impurity.
A Convenient Stereoselective Reduction of Gem-Dibromides with a Combination of Dimethyl Phosphite and Potassium Carbonate
Creators: name: Yalei Zhao
name: Tieqiao Chen
name: Wang, Xiang-Bo
name: Li-Biao Han
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Engineering

description: GRAPHICAL ABSTRACT
Synthesis, Crystal Structure, and Biological Activity of Some Novel Sulfoxide Compounds Containing 1,2,3-Thiadiazole Moiety
Creators: name: Min, Li-Jing
name: Yang, Ming-Yan
name: Sun, Zhao-Hui
name: Tan, Cheng-Xia
name: Weng, Jian-Quan
name: Liu, Xing-Hai
name: Zhang, Yong-Gang
name: Mu, Jin-Xia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: GRAPHICAL ABSTRACT
ANALYZING OF PHYSICAL LOAD IN TRAINING AND COMPETITION ACTIVITY IN COMBAT SPORTS
Creators: name: Rishad Badayev
name: Farkhod Kulbulov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: training
combat
physical load
analyzing
comparison

description: Analyzing training and competition load is important factor for identifying of athletes preparedness. In this article training and competition load of combat sports are studied. Results of the research showed that training load is lower than competition. According to these indicators coaches can plan their training and competition programs more efficiently.
Bismuth(III) Chloride Mediated Michaelis–Arbuzov Reaction: A Facile Synthesis of Substituted Arylphosphonates/Phosphinates and Bioactivity Evaluation
Creators: name: Ch. Subramanyam
name: G. Madhava
name: S. K. Thaslim Basha
name: S. Rasheed
name: C. Naga Raju
name: A. Uday Sankar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences

description: GRAPHICAL ABSTRACT
Coplas nuevas en alabanza de María santísima de la Aurora: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Coplas nuevas en alabanza de María santísima de la Aurora: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
APPLICATION FEATURES METHOD IN PROCESS OF EDUCATIONAL DISCUSSION IN THE FOREIGN LANGUAGE CLASSROOM
Creators: name: Yusupova, Nigina
name: Abduramanova, Diana Valeryevna
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: teaching foreign language
speech
language skills
speech activity
interactive methods of teaching.

description: Teaching a foreign language includes various types of speech and mental activity, contributes to the formation of the ability to think clearly, perceive information critically, highlight the main idea in it and find means and arguments to confirm and substantiate it, and, therefore, facilitate the understanding of any theoretical material. Conscious mastering by students of the relevant material presented by the teacher presupposes the possession of the skills of argumentative perception of speech. In addition, mastering the norms of rational speech communication, the rules for conducting discussions forms a responsible attitude to speech, which is one of the most important requirements for a modern specialist in any field of activity. In addition, the formation of debatable and argumentative skills is necessary for the full development of the communicative and intellectual self-sufficiency of the individual. The discussion method, as one of the methods of problem-based learning, is increasingly used in foreign language classes, including professionally oriented learning, mainly because it allows you to seamlessly integrate the knowledge of students from different fields when solving a problem, makes it possible apply language knowledge and skills in practice, while generating new ideas
APTAMERS AND THEIR USE IN BIOLOGY AND MEDICINE APTAMERS AND THEIR APPLICATIONS IN NANOTECHNOLOGIES, VIROLOGY AND BIOLOGY
Creators: name: M. A. Mustafakulov
name: A. A. Ibragimov
name: A. A. Ashurov
name: A. I. Uralov
name: Sh. Kuziev
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: aptamers
use
biology
medicine
applications
nanotechnologies
virology

description: Aptamers are single-stranded DNA or RNA molecules that have a specific spatial structure and, due to this, are able to recognize other molecules or even exhibit catalytic activity. Note that such spatial structures can only be formed by singlestranded DNA or RNA, since their double-stranded forms have a double helix structure regardless of sequence. The name aptamer comes from the Latin aptus, meaning suitable
AVTOMOBILLARAGA EKSPLUATATSIYA SHAROITIDA TURG’UNLIGINI SAQLASHGA TA’SIR QILUVCH VA ULARNI TA’SIRINI KAMAYTIRISH CHORA-TADBIRLARINI KO’RISH
Creators: name: Norqo’Ziyev, Akmal Baxtiyor O’G’Li
name: Halilov, Bobur Baxtiyorovich
name: Bolqiboyev, Nurali Ilhom O‘G‘Li
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: turg’unlik
sirpanish
ekspluatatsiya
ko’ndalang turg’unlik
bo’ylama turg’unlik
ag’darilish
kritik tezlik
avtomobil koleyasi
Stability
skidding
operation
lateral stall
longitudinal stall
rollover
critical speed
highway

description: Ushbu maqolaqda, Avtomobil turg’unligini saqlashiga ekspluatatsiya sharoitida ta’sir qiluvchi kuchlar va ularni ta’sirini kamaytirish usullari xaqida tushuntirilgan
description: This article explains the forces that affect the stability of a vehicle in service conditions and how to reduce their impact.
AVTOMOBIL SHINALARINI ISHLAB CHIQARISH VA ESKIRGAN AVTOMOBIL SHINALARINI UTILIZATSIYA QILISH BO'YICHA EKSPERIMENT O'TKAZISH USULI
Creators: name: Qaxramon Xusanboy O’G’Li Masodiqov
name: Xujamqulov, Sardor
name: Jaxongir Xasanboy O’G’Li Masodiqov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Shina
component
radial
dioganal
Michelin
Goodyear
Continental
Bridgestone
Kama
Medved

description: Ushbu maqola avtomobil shinalari ishlash samaradorligini oshirishga qaratilgan.
Tween 20-/H2O Promoted Green Synthesis, Computational and Antibacterial Activity of Amino Acid Substituted Methylene Bisphosphonates
Creators: name: S. Siva Prasad
name: S. H. Jayaprakash
name: P. Sreelakshmi
name: C. Suresh Reddy
name: Ch. Syamasundar
name: C. Bhuvaneswar
name: B. Vijaya Bhaskar
name: W. Rajendra
name: S. K. Nayak
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
AVTOTRANSPORT VOSITALARINING EKSPLUATATSION XUSUSIYATLARINI KUZATISH BO'YICHA VAZIFALARNI SHAKLLANTIRISH
Creators: name: Xujamqulov, Sardor Umidjon O‘G‘Li
name: Qahramon Xusanboy O‘G‘Li Masodiqov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: avtotransport
ekspluatatsiya
avtomobil
transport
konstruksiya
texnika
avtobus

description: Ushbu maqolada avtotransport vositalarining ekspluatatsion xususiyatlarini kuzatish bilan bog'liq vazifalar shakllantirilgan
BEHINING (CYDONIA OBLONGA MILL) MORFO-BIOLOGIK XUSUSIYATLARI VA ISTIQBOLLI NAVLARINI O‘RGANISH
Creators: name: Ixtiyor Choriyevich Namozov
name: Xoliqov, Akmal
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: behi
nav
o„simlik
daraxt
meva
mevalar tarkibi
tuproq
harorat
namlik
kasallik
zararkunanda
hosil.
quince
variety
plant
tree
fruit
content
soil
temperature
humidity
diseases
pests
yield

description: Maqolada behining morfo-biologik xususiyatlari, kelib chiqishi, tarqalishi va mevasining foydali xususiyatlari to„g„risidagi ma‟lumotlar keltirilgan. Respublikamizda qishloq xo„jaligi ekinlarining yo„qolib ketish xavfi ostida bo„lgan noyob belgi va xususiyatlarga ega meva turlariga, shu jumladan shifobaxsh ahamiyatga ega bo„lgan behi o„simligining qadimiy navlarini ko„paytirish, ona bog„larini yaratish hamda seleksiya uchun birlamchi manbalar ajratib olish muhim ahamiyatga ega hisoblanadi.
description: The article presents data on the morpho-biological characteristics, origin, distribution and useful properties of quince fruits. Particular attention is paid to the conservation of species of fruit crops with unique characteristics and properties that are on the verge of extinction, in particular, the reproduction of native varieties of quince with high useful properties, the laying of their mother gardens, and the allocation of primary materials for breeding purposes is an urgent issue
BOSHLANG‘ICH SINFLARDA MIQDORLAR TUSHUNCHASINI KOMPETENSIYAVIY YONDASHUV ASOSIDA O’RGATISH
Creators: name: Ra’No Erjigitovna Shakarbayeva
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: ta’lim
tarbiya
boshlang’ich ta’lim
matematika
miqdorlar
hajm
sig’im
kompetensiya
natija
kompetentlik
education
upbringing
primary education
mathematics
quantities
compensation
the result
competence

description: Umumiy o‘rta-ta‘lim jarayonining sifati va samaradorligini oshirish uchun, jumladan miqdorlarni o‘rgatishda uzluksiz matematik ta‘lim tizimi jarayonida pedagogik tajribani o‘rganish, zamonaviy talablar asosida miqdorlarni o‘rgatishda kompetensiyaviy yondashuv zarurdir. Maqolada boshlang’ich sinflarda miqdorlar tushunchasini o’rgatishda kompetensiyaviy yondashuv haqida so’z boradi.
description: Improve the quality and efficiency of the process of general secondary education, including the study of pedagogical experience in the process of continuous mathematical education in teaching quantities, a competence-based approach to teaching quantities based on modern requirements is necessary. The article will focus on the competence-based approach to teaching the concept of quantities in primary schools.
BROKKOLI KARAMINING OZIQ OVQAT HAVSIZLIGIDA TUTGAN OʻRNI
Creators: name: Sirojiddin Qo‘Shoqovich Qahhorov
name: Sobir Toyirovich Sanayev
name: Botirov, Alisher Ekinovich
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Brokkoli karami
karamboshi
asosiy ingrediyentlar
protein
K vitamini
foydali xususiyatlari
oziq-ovqat xavfsizligi.
broccoli
eatible part
main ingredients
vitamin K
useful properties
food safety

description: Brokkoli (Brassica oleracea var. Italica) karamdoshlar oilasiga mansub bo‘lib o‘zining kimyoviy tarkibi, oziqaviylik xususiyati va shifobaxshligi bilan ajralib turadi. Bu maqolada brokkoli karamining ahamiyati, biokimyoviy tarkibi va foydali xususiyatlarini hisobga olgan holda insonlarning oziq ovqat havfsizligida tutgun oʻrniga eʼtibor qaratgan holda bir qancha adabiyotlar yuzasidan tahlil qilindi. Shu asnoda quyidagi xulosalar jamlandi; havo harorati +20°С ga yetgandan buning karamboshi yaxshi shakillanishi, organizmga nisbatan yengil hazm bo’lishi va inson organizmidagi xolistirin moddasini yig’ilishini oldini olishi kabi xususiyatlari o’rganildi. Brokkoli karami bugungi kunda kundalik oziq-ovqat ratsionida o‘zining dietalik xususiyatini hisobga olgan holda keng jamoaga tadbiq qilsa maqsadga muvofiq bo‘ladi.
description: Broccoli (Brassica oleracea var. Italica) belongs to the cauliflower family and is distinguished by its chemical composition, nutritional properties and medicinal properties. This article analyzes a number of publications, focusing on the role of broccoli in human food safety, given its importance, biochemical composition and beneficial properties. In this regard, the following conclusions were made; when the air temperature reaches + 20 ° C, its properties such as good formation of cabbage, easy digestion by the body and prevention of accumulation of cholesterol in the human body have been studied. Broccoli cabbage is now widely used in the daily diet, taking into account its dietary properties
Synthesis and Characterization of New 3″,5″-DIARYL-3″H-Dispiropyran/Thiopyran[4,2′-Chroman-3′,2″-[1,3,4-Thiadiazol]-4′-One Derivatives and Related Compounds as Anticancer and Antiviral Agents
Creators: name: Ali, Mamdouh M.
name: Hegab, Mohamed I.
name: Eman. M. H. Morsy
name: El-Megeid, Ahmed E. Abd
name: W. M. El-Senousy
name: Tolan, Hala E. M.
name: Gad, Farouk A.
name: Abdel-Megeid, Farouk M. E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
A Highly Efficient and Eco-Friendly Approach for the Synthesis of Triarylpyridine and Novel Triaryl-[1,3]Thiazepine Derivatives Via Ring Transformation and Expansion of Triarylthiopyrylium Salts
Creators: name: Mouradzadegun, Arash
name: Somayeh Elahi
name: Parastoo Ghanbarzadeh
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences

description: GRAPHICAL ABSTRACT
GENERAL RULES FOR CREATING AND USING MULTIMEDIA ELECTRONIC TEXTBOOKS ON "DIGITAL AND INFORMATION TECHNOLOGY" IN HIGHER EDUCATION
Creators: name: Mersaid Mirsidikovich Aripov
name: Tillaev, Azamat Ibragimovich
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Digital and information technology
electronic textbooks
multimedia technologies
video lecture
high education
educational process
multimedia software tools
distance education.

description: This article describes the rules and methods of using multimedia e-textbooks to increase the effectiveness of the educational process in higher education. The possibilities and general rules of software used in the creation of multimedia electronic textbooks on the example of the subject "Digital and Information Technology" are also described.
Catherine Hordelalay (UVSQ)
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (1 page).
HELIANTHUS ANNUUS L. ЎСИМЛИГИ НАМУНАЛАРИДА СУВ АЛМАШНУВ ХУСУСИЯТЛАРИ
Creators: name: Ориф Хушбоқович Омонов
name: Ойбек Одил Ўғли Муротов
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: кунгабоқар
физиология
сув ушлаш
намуна
донор
ҳосилдор
вариация коэффициенти

description: Мақолада Helianthus annuus L. турига мансуб хорижий намуналари Тошкент вилояти шароитига экилиб, ўсимликнинг физиологик хусусиятларидан баргларни сув ютиш ва сувни ушлаш хусусиятлари таҳлил қилинган. Тошкент вилояти дала шароитида кунгабоқар ўсимлигининг маҳаллий ва хорижий сув ушлаш ва сув ютиш хусусиятлари Жахонгир, 9848Степняк (Россия), 30835-C 207 (Туркия), 9859-S 01 (АҚШ) нав ва намуналарида юқори кўрсаткичлар аниқланди. Мойли экинлар селекциясида физиологик хусусиятларга эга бўлган намуналар бошланғич манба сифатида тавсия этилади.
Synthesis of Novel Silanes Functionalized with Mono- and Bis-Fluoroalkylated [1,2,3]-Triazoles
Creators: name: Cai, Lu
name: Zhanxiong Li
name: Wanjun Wang
name: Yanhua Yuan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry

description: GRAPHICAL ABSTRACT
HISTORICAL-LEGAL DEVELOPMENT OF CONCEPT OF LOBBYISM
Creators: name: Sohibjon Olimjon Ogli Olimjonov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Lobbying
term
task
function
types
foreign experience
stages
normative-legal document
foreign countries

description: In this thesis, it describes the definition of lobbying by foreign scholars, issues aimed at revealing its essence, as well as the positive and negative features of this phenomenon.
IKKINCHI JAHON URUSHI YILLARIDA O`ZBEKISTONDA EVAKUATSIYA JARAYONLARI: MUAMMOLAR VA YECHIMLAR (OLIY TA'LIM MUASSASALARI MISOLIDA)
Creators: name: Ismoil Salomov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Evakuatsiya
institut
inventarizatsiya
auditoriya
universitet
oliy ta`lim

description: Ushbu maqolada Ikkinchi jahon urushi yillarida amalga oshirilgan evakuatsiya jarayonlari (asosan, oliy o`quv yurtlari va ilmiy tashkilotlar) haqida ma`lumot berilgan. Evakuatsiya jarayonlarida vujudga kelgan muammolar va ularning bartaraf etilishi, ko`chirib keltirilgan oliy ta`lim muassalari va tashkilotlari uchun o`quv binolari va talabalar turar-joylarining ajratilishi, o`quv jarayonlarining urush talablari asosida qayta qurilganligi, ko`chirilgan oliy ta`lim muassalarining mahalliy oliy o`quv yurtlari bilan birlashtirilishi haqidagi ma`lumotlar arxiv materiallari yordamida ochib berishga harakat qilingan.
ILK O’RTA ASRLARDAGI AFROSIYOB DEVORIY SURATLARI
Creators: name: Sa’Dullayev, Sanjar
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: innovatsiya
devoriy suratlar
arablar istilosi
Yui shaharcha
ensiz naqsh
Varxumana
zandanachi
Domision tobuti
so’g’dlar turmushi

description: Ilk o’rta asrlar rang-tasvir san’atining O’rta Osiyo miqyosidagi rivoji Afrosiyob devoriy suratlarida yaqqol namoyon bo’ladi. Afrosiyob devoriy suratlari faqatgina ilk o’rta asrlar ma’naviyati, madaniyati rivojidan dalolat berib qolmay, balki o’sha davr ichki va tashqi siyosati, iqtisodiyoti hamda hunarmandchilik rivojining ham yaqqol isbotidir.
1-Isothiocyanatosilatrane Derived from Asymmetric Tetradentate Ligand: Synthesis, Structural Analyses, Reactivity, and Computational Studies
Creators: name: Gurjaspreet Singh
name: Shally Girdhar
name: Amandeep Saroa
name: , Promila
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
INGLIZ TILI FANINI BILINGUAL O‘QITISH VA FAKULTATIV DARSLAR UCHUN CASE STUDY METODIDAN FOYDALANISH
Creators: name: Bog‘Dagul Faxriddinovna Qarshiyeva
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: rotate through angle
terminal speed
muammoli vaziyatlar (case studies)

description: Ushbu maqolada ingliz tili fanini bilingual o„qitish va fakultativ darslar uchun case study metodidan foydalanish masalasi ilmiy asoslarga tayanib ko‟rib chiqiladi.
One-Pot Synthesis of Functionalized Pyrimido[2,1-B][1,3]Thiazin-6-Ones Via a Multicomponent Reaction
Creators: name: Yadollahzadeh, Khadijeh
name: Azizian, Javad
name: Haleh Sanaeishoar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
INGLIZ VA O'ZBEK TILLARIDA TURIZM LEKSEMALARI
Creators: name: Oglonoy Allamurodovna Xudoynazarova
name: Torayeva, Dilbar Shuhrat Qizi
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: subject: Tourism
subject: FOS: Economics and business
subject: tourism word units
subject: touristic expressions

description: Ushbu maqola turizm so'zlari, turizm bilan bog`liq birliklari va ularning ma'nolarini ingliz tillarida ifodalashga bag'ishlangan.
Introduction of a New Ionic Liquid Catalyst for the Trimethylsilyl and Tetrahydropyranyl Protection of Alcohols
Creators: name: Shirini, Farhad
name: Abedini, Masoumeh
name: Nosratollah Mahmoodi
name: Biglari, Mohammad
name: Mohaddeseh Safarpoor Nikoo Langrudi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
INSON ORGANIZMINING OG’IR METALLAR BILAN ZARARLANISH YO’LLARI
Creators: name: Karimov, Amir Andarmonovich
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Zirabuloq tog’-kon sanoati korxonalari
og’ir metallar
yer osti suvlari
suv sifati
og’ir metallarning inson organizmiga ta’siri
metallarning zaharliligi
og’ir metallarning tarqalish manbalari.
Zirabulak mining enterprises
heavy metals
groundwater
water quality
the impact of heavy metals on the human body
toxicity of metals
sources of heavy metals.

description: Atrof-muhitning og’ir metallar bilan ifloslanishi muammosining dolzarbligi birinchi navbatda, inson organizmiga ta’sirining keng doirasi bilan izohlanadi. Og’ir metallar oraganizmning deyarli barcha tizimlariga ta’sir qiladi, toksik, allergik, kanserogen, gonadotrop kabi ta’sir ko’rsatish xususiyatlariga ega.
description: The urgency of the problem of environmental pollution with heavy metals is explained, first of all, by a wide range of effects on the human body. Heavy metals affect almost all body systems, have toxic, allergic, carcinogenic, gonadotropic properties.
Synthesis, Antioxidant, Anti-Inflammatory, and Antimicrobial Screening of Newer Thiophene-Fused Arylpyrazolyl 1,3,4-Oxadiazoles
Creators: name: Pravin Mahajan
name: Nikam, Mukesh
name: Chate, Asha
name: Urja Nimbalkar
name: Vrushali Patil
name: Bobade, Anil
name: Chaudhari, Abhay
name: Dattatray Deolankar
name: Balasaheb Javale
name: Charansingh Gill
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology

description: GRAPHICAL ABSTRACT
Graphene Oxide-Assisted One-Pot and Odorless Synthesis of Symmetrical Disulfides Using Primary and Secondary Alkyl Halides (Tosylates) and Thiourea as Sulfur Source Reagent
Creators: name: Khalili, Dariush
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
Novel Aryl Substituted Silanes Part I: Synthesis and Characterization of Diaryl Silicon Dichlorides
Creators: name: Flock, Michaela
name: Torvisco, Ana
name: Uhlig, Frank
name: Binder, Judith
name: Fischer, Roland C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: GRAPHICAL ABSTRACT
Implications of external price referencing of pharmaceuticals in Middle East countries
Creators: name: Vokó, Zoltán
name: Kaló, Zoltán
name: Alabbadi, Ibrahim
name: Ahdab, Ola Ghaleb Al
name: Alowayesh, Maryam
name: Elmahdawy, Mahmoud
name: Abdulaziz H Al-Saggabi
name: Tanzi, Vito Luigi
name: Al-Badriyeh, Daoud
name: Alsultan, Hamad S
name: Faleh Mohamed Hussain Ali
name: Gihan H Elsisi
name: Akhras, Kasem S
name: Kanavos, Panos
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Pharmacology

description: Introduction: External price referencing (EPR) is applied frequently to control pharmaceutical prices. Our objective was to analyse how EPR is used in Middle Eastern (ME) countries and to compare the price corridor for original pharmaceuticals to non-pharmaceutical services not subjected to EPR. Methods: We conducted a survey on EPR regulations and collected prices of 16 patented pharmaceuticals and 14 non-pharmaceutical services in seven Middle Eastern (ME) countries. Maximum and minimum prices of each pharmaceutical and non-pharmaceutical technology were compared to mean prices in the countries studied by using market exchange rates. Influencing factors of pharmaceutical prices were assessed by multivariate linear regression analysis. Results: The average price corridor is narrower for pharmaceuticals (−39.8%; +35.9%) than for outpatient and hospital services (−81.7%; +96.3%). Conclusion: Our analysis revealed the importance of population size and EPR implementation on drug price levels; however, EPR results in higher pharmaceutical prices in lower-income countries compared to non-pharmaceutical services.
Targeting different RNA motifs by beta carboline alkaloid, harmalol: a comparative photophysical, calorimetric, and molecular docking approach
Creators: name: Paromita Bhattacharjee
name: Sarkar, Sarita
name: Prateek Pandya
name: Kakali Bhadra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: RNA has attracted recent attention for its key role in gene expression and targeting by small molecules for therapeutic intervention. This work focuses towards understanding interaction of harmalol, a DNA intercalator, with RNAs of different motifs viz. single-stranded A-form poly(A), double-stranded A-form of poly(C)·poly(G), and clover leaf tRNAphe by different spectroscopic, calorimetric, and molecular modeling techniques. Results of this study converge to suggest that (i) binding constant varied in the order poly(C)·poly(G) > tRNAphe > poly(A), (ii) non-cooperative binding of harmalol to poly(C)·poly(G) and poly(A) and cooperative binding with tRNAphe, (iii) significant structural changes of poly(C)·poly(G) and tRNAphe with concomitant induction of optical activity in the bound achiral alkaloid molecules, while with poly(A) no induced Circular dichroism (CD) perturbation was observed, (iv) the binding was predominantly exothermic, enthalpy-driven, entropy-favored with poly(C)·poly(G), while it was entropy driven with tRNAphe and poly(A), (v) a hydrophobic contribution and comparatively large role of non polyelectrolytic forces to Gibbs energy changes with poly(C)·poly(G) and tRNAphe and (vi) intercalated state of harmalol inside poly(C)·poly(G) structure as revealed from molecular docking was supported by the viscometric and ferrocyanide quenching data. All these findings unequivocally pointed out that harmalol prefers binding with poly(C)·poly(G), compared to tRNAphe and poly(A); this results serve as data for the development of RNA-based antiviral drugs. This work focuses to understand the interaction of harmalol with RNAs of different motifs viz. single-stranded A-form poly(A), double-stranded A-form of poly(C)·poly(G) and clover leaf tRNAphe by different spectroscopic, and calorimetric techniques, and molecular docking methods. The findings unequivocally point out that harmalol prefers to bind strongly to poly(C)·poly(G) in an intercalative mode, compared to a weak binding to tRNAphe and poly(A). The results may serve in the design of RNA-targeted antiviral drugs.
INTELLEKTUAL MATN TAHLILI
Creators: name: Sabohat Yusupboyevna Allanazarova
name: Abduraxmonova, Nilufar Zaynobiddin Qizi
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: sentiment tahlili
tonallik
ijtimoiy tarmoq
ma‟lumotlar bazasi
xizmatlarni baholash
sentiment analysis
tonality
social network
database
evaluation of services

description: Fan va texnikaning yuksak darajada rivojlanishi natijasida ijtimoiy saytlar orqali qabul qilinadigan ma‟lumotlar hajmi boshqarib bo„lmaydigan tarzda keskin oshib ketdi. Ko'pchilik foydalanuvchilar duch keladigan asosiy muammo vaqt yetishmasligi. Sababi, barcha ma‟lumotlarni o„qishning iloji yo„q. Bu esa ushbu ma‟lumotlarni saralash zaruratini tug‟diradi. Shu sababli Tabiiy tillar jarayoni (NLP), Mashinaviy o‟qitish (Machine learning), Ma‟lumotlarga ishlov berish (Data Science) va Sun‟iy intellekt kabi sohalarga qiziqishning o„sishi kuzatildi. XXI asr texnologiyalar va intellektual salohiyat asrida insonlarning fikrini o„rganish bo„yicha yangi metod paydo bo„ldi.
description: As a result of the high level of development of science and technology, the amount of information received through social sites has increased dramatically. The main problem that most users face is lack of time. Because not all data can be read. Which makes it necessary to sort this data. Therefore, there has been an increase in interest in areas such as the natural language process (NLP), machine learning, data science and artificial intelligence. The 21st century, in the age of technology and intellectual potential, a new method of studying people's opinions has emerged.
ITALYAN VA INGLIZ TILLARIDAGI AYRIM RANG KOMPONENTLI IBORALARNING SEMANTIKASI
Creators: name: Behzod Xudoyqulov
name: Mushtariybonu Yangiboyeva
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Frazeologiya
ibora
tarjima
asliyat
ekvivalent
Phraseology
phraseological unit
translation
originality
equivalent.

description: Har bir tilda bo’lgani kabi italyan va ingliz tillarida ham frazeologik iboralar muhim tadqiqot mavzusi bo’lib, shu paytgacha ko’plab tilshunoslar tomonidan o’rganilib kelinmoqda. Boshqa chet tillari kabi italyan va ingliz tillari ham iboralarga boy til hisoblanadi. Shuning uchun ham bu tillardagi iboralarni turli jihatdan o’rganish, jumladan, tematik tasniflash yoki tarjima orqali ma’nolarini tadqiq etish muhimdir. Mazkur maqolada italyan va ingliz tillaridagi rang komponentli iboralar tahliliga bag’ishlangan. Maqolada rang komponentli iboralar va ularning semantik xususiyatlari turli misollar orqali tahlil qilingan
description: As in any language, phraseology in Italian and English is an important research topic and has been studied by many linguists to this day. Like other foreign languages, Italian and English are rich in expressions. That is why it is important to study the meanings of phrases in these languages from different angles, including thematic classification or translation. This article analyzes the colour component phrases in Italian and English. The article analyses color component phrases and their semantic properties through various examples.
title: Efficacy and safety of cannabinoids in the treatment of spasticity in patients with multiple sclerosis: a rapid review
Creators: name: Pereira, Viviane
name: Camargo, Erika Barbosa
name: De Melo Barbosa, Aurélio
name: Ferreira, Fernanda Pimenta Simon
name: Silvério, Lilyan Oliveira
name: Nascimento, Maria Helha Fernandes Do
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Cannabinoids
subject: Multiple sclerosis
subject: Rapid review
subject: Spasticity

description: This project aims to conduct a rapid review to evaluate the safety and efficacy of cannabinoid medications in treating spasticity in adult patients with Multiple Sclerosis (MS), compared to placebo or standard treatments. The team consists of health professionals and researchers from various fields, indicating a multidisciplinary approach. The protocol follows guidelines from the Joanna Briggs Institute and the PRISMA statement, emphasizing a transparent and systematic process in the selection and analysis of evidence. The review seeks to contribute valuable insights into alternative therapies for managing spasticity in MS, a challenging symptom of the disease, to improve the quality of life of individuals affected by MS.
JAMOATCHILIK NAZORATI VA UNI TASHKIL ETISHDA YOSHLARNING O‘RNI VA ROLI
Creators: name: Ikramov, Ravshan Aktamovich
name: Umidbek Xaitbayevich Adambayev
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: jamoatchilik
nazorat
jamiyat
mahalla
oila
ijtimoiy tarmoq
yoshlar
davlat
hokimiyat.
public
control
society
neighborhood
family
social network
youth
state
government.

description: Ushbu maqolada jamoatchilik nazorati tushunchasiga g‘arb olimlarining mulohazalari, jamoatchilik nazoratini tashkil etishda davlatning roli, Yangi O‘zbekistonda yangidan qad rostlayotgan mahallalar va ularda yashovchi oilalarning jamoatchilik nazoratini tashkil etishdagi faolligi, mahalla yoshlarning mamlakatda bo‘layotgan siyosiy jarayonlardagi ishtiroki, davlat rahbari tomonidan yoshlarga qaratilayotgan e’tibor va yoshlarning jamoatchilik nazoratini tashkil etishdagi harakatlari to‘g‘risida mulohazalar berilgan.
description: This article discusses the concept of public control, the role of the state in organizing public control, the activity of newly formed microdistricts and their families in organizing public control in new Uzbekistan, the participation of district youth in political processes in the country. y attention and feedback on the actions of young people in the organization of public control.
JON GOLSUORSINING “ADABIYOTDA XARAKTER YARATISH” ASARI BADIIY VA FALSAFIY XUSUSIYATLARI
Creators: name: Abror Samad O„G„Li Ismatov
name: Hakimov, Bobur Yangiboy O„G„Li
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: adabiyot
Yevropa
sanoq
sahna
Gamlet
Shekispir

description: Badiiy tafakkur orqali borliq ranglarini uqish va o„qish usul va uslublari behisob. Bu borada Yevropa adabiyotshunoslarining tadqiqotlari e‟tiborga sazovor. Badiiy g„oya yaratish jarayonida muallifning tip, xarakter va obrazning paradigmatik imkoniyatlaridan foydalanish mahorati germenevtik sharoitni to„g„ri belgilash imkoniyatini yaratib, bu hodisa ko„plab tadqiqotlarning markazida turgan.
Cytotoxic scalarane-type sesterterpenes from the Saudi Red Sea sponge Hyrtios erectus
Creators: name: Walied M. Alarif
name: Al-Lihaibi, Sultan S.
name: Ghandourah, Mohamed A.
name: Orif, Mohamed I.
name: Basaif, Salim A.
name: Seif-Eldin N. Ayyad
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry

description: The CHCl3/MeOH extract of the marine sponge Hyrtios erectus showed cytotoxicity against three cancer cell lines HepG2, A549, and PC-3 with IC50 0.055, 0.044, and 0.023 μg/ml, respectively. The CH2Cl2 soluble fraction afforded three scalarane sesterterpenes (1–3) along with a cholestane derivative (4) and an indole alkaloid (5). Chemical structures were established by spectroscopic techniques and comparison with data reported in the literature. Scalarinol (1) was found as a new metabolite, while heteronemin (2) and 12-O-deacetyl-19-deoxyscalarin (3) are known compounds. 1–3 exhibited cytotoxic activity against the cancer cell lines with IC50 values ranging from 14 to 230 μM. The molecular affinity to the DNA was employed as marker to examine the proposed mechanism of cytotoxic activities. Compound 2, with IC50 28 μg/ml, displayed the highest affinity to the DNA.
JO’XORINING QURG’OQCHILIK VA SHO’RLANISHGA TA’SIRI
Creators: name: Jo’Rayeva, Ozoda Toirovna
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Sho’rga chidamli o’simliklar
transpirasiya koeffisienti
havo ildizlar
ildiz bachkilari
pestitsid
ro’vak
so’ta
o’tmishdosh o’simlik
harorat yig’indisi.
Salt-tolerant plants
transpiration coefficient
aerial roots
rootstocks
pesticide
rhubarb
soybean
past plant
temperature sum

description: Jo’xori eng qurg’oqchil o’simlik 200 ga yaqin, u jazirama issiqqa eng chidamli don ekinlaridan biri. Jo’xori urug’i tuproq harorati 12-14°Cda yaxshi, 16-18°C da tez unib chiqadi. Yosh va voyaga etgan o’simliklari mutlaqo sovuqqa chidamsiz. Havo harorati 35-40°C da ham o’sa oladi. Urug’i ekilgandan pishib etilguncha 22502500°C foydali harorat yig’indisi zarur. Yorug’likka talabchan, qisqa kun o’simligi. Bulut kam bo’lgan quyoshli tumanlarda yuqori hosil beradi. Jo’xorining transpirasiya koeffisienti boshqa don ekinlariga qaraganda past, ildizlari tuproqqa chuqur kirib, bor namlikdan tejab foydalanadi. Hosildor, unumdorligi yuqori bo’z, o’tloqi bo’z, qora, kashtan tuproqlarda yaxshi o’sib yuqori hosil beradi. Jo’xori tuproqqa unchalik talabchan emas, sho’r erlarda ham yaxshi o’sadi. Lekin suv va havo aerasiyasi yaxshi tuproqlar uning uchun juda mos keladi. Hamma tariqsimon ekinlar singari jo’xori ham dastlabki paytda sekin o’sadi va dalani o’t bosishiga chidamsiz bo’ladi. Jo’xori ekilgandan 10-15 kundan keyin maysalaydi, 25-30 kundan keyin tulanish fazasiga kiradi. Maysalagandan 40-50 kundan keyin nay o’raydi, 55-65 kundan keyin ro’vak chiqaradi. Ro’vak chiqargandan 5-6 kundan keyin gullaydi. Navlarning tez pisharligiga qarab o’suv davri 90-145 kun davom etadi. Sho’rlangan tuproqlarda o’suvchi o’simliklarni aniqlash va ularning vegitatsiya davridagi o’zgarishlari haqida ma’lumotlar keltirilgan
description: Corn is the driest plant of about 200, making it one of the most heat-resistant cereals. Corn seeds germinate well at a soil temperature of 12-14 ° C and quickly at 16-18 ° C. Young and mature plants are absolutely resistant to cold. Temperatures can rise as high as 35-40 ° C. A useful total temperature of 22502500 ° C is required from sowing to ripening. Light-demanding, short-day plant. Yields high in low-cloud areas. Corn has a lower transpiration coefficient than other cereals, and its roots penetrate deep into the soil, saving moisture. Grows well in fertile, high-yielding gray, meadow gray, black, chestnut soils and gives high yields. Corn is not very demanding on the soil and grows well in saline soils. But water and air aeration good soils are very suitable for it. Like all cereals, corn grows slowly at first and is resistant to fire. Corn sprouts 10-15 days after sowing and enters the ripening phase after 25-30 days. After 40-50 days of mowing, the reeds are wrapped, and after 55-65 days, the stalks emerge. It blooms 5-6 days after emergence. The growing season lasts 90-145 days, depending on the rapid ripening of the varieties. Information on the identification of plants growing in saline soils and their changes during the growing season
Targeting different RNA motifs by beta carboline alkaloid, harmalol: a comparative photophysical, calorimetric, and molecular docking approach
Creators: name: Paromita Bhattacharjee
name: Sarkar, Sarita
name: Prateek Pandya
name: Kakali Bhadra
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: RNA has attracted recent attention for its key role in gene expression and targeting by small molecules for therapeutic intervention. This work focuses towards understanding interaction of harmalol, a DNA intercalator, with RNAs of different motifs viz. single-stranded A-form poly(A), double-stranded A-form of poly(C)·poly(G), and clover leaf tRNAphe by different spectroscopic, calorimetric, and molecular modeling techniques. Results of this study converge to suggest that (i) binding constant varied in the order poly(C)·poly(G) > tRNAphe > poly(A), (ii) non-cooperative binding of harmalol to poly(C)·poly(G) and poly(A) and cooperative binding with tRNAphe, (iii) significant structural changes of poly(C)·poly(G) and tRNAphe with concomitant induction of optical activity in the bound achiral alkaloid molecules, while with poly(A) no induced Circular dichroism (CD) perturbation was observed, (iv) the binding was predominantly exothermic, enthalpy-driven, entropy-favored with poly(C)·poly(G), while it was entropy driven with tRNAphe and poly(A), (v) a hydrophobic contribution and comparatively large role of non polyelectrolytic forces to Gibbs energy changes with poly(C)·poly(G) and tRNAphe and (vi) intercalated state of harmalol inside poly(C)·poly(G) structure as revealed from molecular docking was supported by the viscometric and ferrocyanide quenching data. All these findings unequivocally pointed out that harmalol prefers binding with poly(C)·poly(G), compared to tRNAphe and poly(A); this results serve as data for the development of RNA-based antiviral drugs. This work focuses to understand the interaction of harmalol with RNAs of different motifs viz. single-stranded A-form poly(A), double-stranded A-form of poly(C)·poly(G) and clover leaf tRNAphe by different spectroscopic, and calorimetric techniques, and molecular docking methods. The findings unequivocally point out that harmalol prefers to bind strongly to poly(C)·poly(G) in an intercalative mode, compared to a weak binding to tRNAphe and poly(A). The results may serve in the design of RNA-targeted antiviral drugs.
KUCHALA (ARUM KOROLKOWII REGEL) ILDIZI EKSTRAKTI ERKAK GVINEYA CHO‘CHQALARIDA TESTOSTERON GARMONIGA TA`SIRI
Creators: name: M. Sh. Jabborov
name: A. I. Uralov
name: M. A. Mustafakulov
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: tuber
Arum korolkowii Regel
10% spirtli damlamasi
qon zardobi biokimyosi
testosteron
gvineya cho'chqasi

description: O`rta Osiyo xalq tabobatida qadim zamonlardan beri tez-tez qo`llaniladigan, hozir ham o`z ahamiyatini yo`qotmagan dorivor o`simliklardan biri Arum korolkowii Regel hisoblanadi. Xalqda bu dorivor o'simlik kuchala deb ataladi. Oʻsimlik juda zaharli boʻlib, xalq tabobatida inson kuchini oshirish uchun dorivor xom ashyo sifatida kichik dozadagi tuber damlamasi qoʻllaniladi [1, 7]. Bu oʻsimlikning shifobaxsh xususiyatlari Avitsenna [4] asarlarida, shuningdek, qirgʻiz xalq dostonlari “Manas” [5, 6] va Semetey [3] da tilga olingan.