cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On abelian cubic fields with large class number
Creators: name: Dousselin, Jérémy
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We investigate the large values of class numbers of cubic fields, showing that one can find arbitrary long sequences of "close" abelian cubic number fields with class numbers as large as possible. We also give a first step toward an explicit lower bound for extreme values of class numbers of abelian cubic fields.
YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment
Creators: name: Gopal, SK
name: Greening, David
name: Mathias, RA
name: Ji, H
name: Rai, A
name: Chen, Maoshan
name: Zhu, H-J
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Epithelial-mesenchymal transition (EMT) describes a morphogenetic program which confers mesenchymal cell properties, such as reduced cell-cell contact and increased cell migration and invasion, to epithelial cells. Here we investigate the role of the pleiotropic transcription/splicing factor and RNA-binding protein nucleasesensitive element-binding protein 1 (YBX1/YB-1) in increasing the oncogenic potential of epithelial MDCK cells. Characterization of MDCK cells expressing YBX1 (MDCKYBX1 cells) revealed a partial EMT phenotype, including cytosolic relocalization of E-cadherin, increased cell scattering, and anchorage-independent growth. Subcutaneous injection of parental MDCK cells into NOD/SCID mice did not form tumours. Critically, MDCKYBX1 cells established viable tumour xenografts, and immunohistochemical staining indicated murine vascularization by CD31+ endothelial cells. We analysed the total secretome (containing soluble and extracellular vesicles) of MDCKYBX1 cells to investigate regulation of the tumour microenvironment. YBX1 expression elevated release of secreted factors known to enhance angiogenesis (TGF-β, CSF-1, NGF, VGF, ADAM9 and ADAM17), compared to MDCK cells. Importantly, treatment with MDCKYBX1 cell-derived secretome increased recipient 2F-2B endothelial cell motility. This defines YBX1 as an oncogenic enhancer that can regulate tumour angiogenesis via release of secreted modulators into the extracellular microenvironment.
Term Interpretation in Patents and Trademarks
Creators: name: Warren, Leigh M.
Publisher: name: Science and Technology Law Review
Year: 2006

description: The doctrine of claim construction has remained unsettled since the Federal Circuit declared it a matter of law ten years ago. Despite recent evidentiary clarification in Phillips, courts still struggle to construe claims as a purely legal matter. Skilled artisans’ interpretive contributions are crucial to accurate constructions, yet factual findings based on those contributions command no formal recognition in current doctrine. This Note proposes a limited role for skilled artisans’ interpretive input in determining the patentee’s intended meaning of a claim term. Specifically, skilled artisans’ interpretation of terms in the specification would be a matter of fact, informing judges’ construction of the claims as a matter of law overall. The new factual component would introduce evidentiary challenges, addressable by drawing on the evidentiary approach for determining trademark distinctiveness. The virtues of joint interpretation include accuracy and trial-level certainty, though its viability is questionable in light of the Supreme Court’s insistence on jury-free construction in Markman.
description: Science and Technology Law Review, Vol 7: 2005-2006
Efficacy of customised foot orthoses in the treatment of Achilles tendinopathy: Study protocol for a randomised trial
Creators: name: Munteanu, Shannon
name: Landorf, Karl
name: Menz, Hylton
name: Cook, Jillianne
name: Pizzari, Tania
name: Scott, LA
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Achilles tendinopathy is a common condition that can cause marked pain and disability. Numerous non-surgical treatments have been proposed for the treatment of this condition, but many of these treatments have a poor or non-existent evidence base. The exception to this is eccentric calf muscle exercises, which have become a standard non-surgical intervention for Achilles tendinopathy. Foot orthoses have also been advocated as a treatment for Achilles tendinopathy, but the long-term efficacy of foot orthoses for this condition is unknown. This manuscript describes the design of a randomised trial to evaluate the efficacy of customised foot orthoses to reduce pain and improve function in people with Achilles tendinopathy.Methods: One hundred and forty community-dwelling men and women aged 18 to 55 years with Achilles tendinopathy (who satisfy inclusion and exclusion criteria) will be recruited. Participants will be randomised, using a computer-generated random number sequence, to either a control group (sham foot orthoses made from compressible ethylene vinyl acetate foam) or an experimental group (customised foot orthoses made from semi-rigid polypropylene). Both groups will be prescribed a calf muscle eccentric exercise program, however, the primary difference between the groups will be that the experimental group receive customised foot orthoses, while the control group receive sham foot orthoses. The participants will be instructed to perform eccentric exercises 2 times per day, 7 days per week, for 12 weeks. The primary outcome measure will be the total score of the Victorian Institute of Sport Assessment - Achilles (VISA-A) questionnaire. The secondary outcome measures will be participant perception of treatment effect, comfort of the foot orthoses, use of co-interventions, frequency and severity of adverse events, level of physical activity and health-related quality of life (assessed using the Short-Form-36 questionnaire - Version two). Data will be collected at baseline, then at 1, 3, 6 and 12 months. Data will be analysed using the intention to treat principle.Discussion: This study is the first randomised trial to evaluate the long-term efficacy of customised foot orthoses for the treatment of Achilles tendinopathy. The study has been pragmatically designed to ensure that the study findings are generalisable to clinical practice. Trial registration: Australian New Zealand Clinical Trials Registry Number: ACTRN12609000829213. © 2009 Munteanu et al; licensee BioMed Central Ltd.
Earth tomography with supernova neutrinos at future neutrino detectors
Creators: name: Hajjar, Rasmi
name: Mena, Olga
name: Palomares-Ruiz, Sergio
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Earth neutrino tomography is a realistic possibility with current and future neutrino detectors, complementary to geophysics methods. The two main approaches are based on either partial absorption of the neutrino flux as it propagates through the Earth (at energies about a few TeV) or on coherent Earth matter effects affecting the neutrino oscillations pattern (at energies below a few tens of GeV). In this work, we consider the latter approach focusing on supernova neutrinos with tens of MeV. Whereas at GeV energies, Earth matter effects are driven by the atmospheric mass-squared difference, at energies below $\sim 100$ MeV, it is the solar mass-squared difference what controls them. Unlike solar neutrinos, which suffer from significant weakening of the contribution to the oscillatory effect from remote structures due to the neutrino energy reconstruction capabilities of detectors, supernova neutrinos can have higher energies and thus, can better probe the Earth's interior. We shall revisit this possibility, using the most recent neutrino oscillation parameters and up-to-date supernova neutrino spectra. The capabilities of future neutrino detectors, such as DUNE, Hyper-Kamiokande and JUNO are presented, including the impact of the energy resolution and other factors. Assuming a supernova burst at 10~kpc, we show that the average Earth's core density could be determined within $\lesssim 10\%$ at $1σ$ confidence level, being Hyper-Kamiokande, with its largest mass, the most promising detector to achieve this goal.
description: 26 pages, 9 figures: matches published version, including two missing lines in the right panels of figure 3
Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways
Creators: name: Greening, David
name: Lee, Sze
name: Ji, H
name: Simpson, Richard
name: Rigopoulos, Angela
name: Murone, C
name: Fang, C
name: Gong, Sylvia
name: O'Keefe, G
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Angiogenesis and epidermal growth factor receptor (EGFR) inhibition has been shown to have anti-tumour efficacy, and enhance the therapeutic effects of cytotoxic chemotherapy in metastatic colorectal cancer. The interplay of signalling alterations and changes in metabolism and hypoxia in tumours following anti-VEGF and anti-EGFR treatment is not well understood. We aimed to explore the pharmacodynamics of cetuximab and bevacizumab treatment in human colon carcinoma tumour cells in vitro and xenograft models through proteomic profiling, molecular imaging of metabolism and hypoxia, and evaluation of therapy-induced changes in tumour cells and the tumour microenvironment. Both cetuximab and bevacizumab inhibited tumour growth in vivo, and this effect was associated with selectively perturbed glucose metabolism and reduced hypoxic volumes based on PET/MRI imaging. Global proteomic profiling of xenograft tumours (in presence of cetuximab, bevacizumab, and combination treatments) revealed alterations in proteins involved in glucose, lipid and fatty acid metabolism (e.g., GPD2, ATP5B, STAT3, FASN), as well as hypoxic regulators and vasculogenesis (e.g., ATP5B, THBS1, HSPG2). These findings correlated with western immunoblotting (xenograft lysates) and histological examination by immunohistochemistry. These results define important mechanistic insight into the dynamic changes in metabolic and hypoxic response pathways in colorectal tumours following treatment with cetuximab and bevacizumab, and highlight the ability of these therapies to selectively impact on tumour cells and extracellular microenvironment.
Object Recognition and Real-Time Tracking in Microscope Imaging
Creators: name: Wedekind, Jan
name: Boissenin, Manuel
name: Amavasai, Bala
name: Caparrelli, Fabio
name: Travis, Jon
Publisher: name: figshare
Year: 2013
Subjects: Applied Computer Science

description: As the fields of micro- and nano-technology mature, there is going to be an increased need for industrial tools that enable the assembly and manipulation of micro-parts. The feedback mechanism in a future micro-factory will require computer vision.
Within the EU IST MiCRoN project, a computer vision software based on Geometric Hashing and the Bounded Hough Transform to achieve recognition of multiple micro-objects was implemented and successfully demonstrated. In this environment, the micro-objects will be of variable distance to the camera. Novel automated procedures in biology and micro-technology are thus conceivable.
This paper presents an approach to estimate the pose of multiple micro-objects with up to four degrees-of-freedom by using focus stacks as models. The paper also presents a formal definition for Geometric Hashing and the Bounded Hough Transform.
Investigating combination HIV prevention: isolated interventions or complex system
Creators: name: Brown, Graham
name: Reeders, D
name: Dowsett, Gary
name: Ellard, Jeanne
name: Carman, Marina
name: Hendry, N
name: Wallace, John
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4202
subject: Epidemiology
classificationCode: 4206
subject: Public health

description: Introduction: Treatment as prevention has mobilized new opportunities in preventing HIV transmission and has led to bold new UNAIDS targets in testing, treatment coverage and transmission reduction. These will require not only an increase in investment but also a deeper understanding of the dynamics of combining behavioural, biomedical and structural HIV prevention interventions. High-income countries are making substantial investments in combination HIV prevention, but is this investment leading to a deeper understanding of how to combine interventions? The combining of interventions involves complexity, with many strategies interacting with non-linear and multiplying rather than additive effects. Discussion: Drawing on a recent scoping study of the published research evidence in HIV prevention in high-income countries, this paper argues that there is a gap between the evidence currently available and the evidence needed to guide the achieving of these bold targets. The emphasis of HIV prevention intervention research continues to look at one intervention at a time in isolation from its interactions with other interventions, the community and the socio-political context of their implementation. To understand and evaluate the role of a combination of interventions, we need to understand not only what works, but in what circumstances, what role the parts need to play in their relationship with each other, when the combination needs to adapt and identify emergent effects of any resulting synergies. There is little development of evidence-based indicators on how interventions in combination should achieve that strategic advantage and synergy. This commentary discusses the implications of this ongoing situation for future research and the required investment in partnership. We suggest that systems science approaches, which are being increasingly applied in other areas of public health, could provide an expanded vocabulary and analytic tools for understanding these complex interactions, relationships and emergent effects. Conclusions: Relying on the current linear but disconnected approaches to intervention research and evidence we will miss the potential to achieve and understand system-level synergies. Given the challenges in sustaining public health and HIV prevention investment, meeting the bold UNAIDS targets that have been set is likely to be dependent on achieving systems level synergies.
Quantum computation in silicon-vacancy centers based on nonadiabatic geometric gates protected by dynamical decoupling
Creators: name: Yun, M. -R.
name: Wu, Jin-Lei
name: Yan, L. -L.
name: Jia, Yu
name: Su, S. -L.
name: Shan, C. -X
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Due to strong zero-phonon line emission, narrow inhomogeneous broadening, and stable optical transition frequencies, the quantum system consisting of negatively charged silicon-vacancy (SiV) centers in diamond is highly expected to develop universal quantum computation. We propose to implement quantum computation for the first time using SiV centers placed in a one-dimensional phononic waveguide, for which quantum gates are realized in a nonadiabatic geometric way and protected by dynamical decoupling (DD). The scheme has the feature of geometric quantum computation that is robust to control errors and the advantage of DD that is insensitive to environmental impact. Furthermore, the encoding of qubits in long-lifetime ground states of silicon-vacancy centers can reduce the effect of spontaneous emission. Numerical simulations demonstrate the practicability of the SiV center system for quantum computation and the robustness improvement of quantum gates by DD pulses. This scheme may provide a promising path toward high-fidelity geometric quantum computation in solid-state systems.
My living-theory of International Development
Creators: name: Briganti, Arianna
Publisher: name: Lancaster University
Year: 2020

description: My thesis is focused on the relationally dynamic values of empathy, social and gender justice, outrage, responsibility, love for and faith in humanity and dignity. The originality lies in their use as explanatory principles in my explanation of my educational influence in my own learning, in the learning of others and in the learning of the social formations that affect my practice as a development professional. My other original contribution to knowledge is to relate the threefold nature of Living Theory methodology – a self-reflexive action-led research, a way of life, and a social movement - with my practice in International Development, which provides an example of how limitations in this sector might be overcome. My self-reflexive research conceptualizes International Development as a global responsibility. It offers instances of how to work with others at micro (community) level, meso (organizational) level and shows my developing understanding of my potential systemic influence at a political (macro) level. By drawing insights mainly from self-study and narrative enquiry methodologies, my living-theory of International Development is presented as an alternative to the neoliberal approach and rests on the idea that Development means having a chance to contribute to a good change (Chambers, 1997, p.1743). My stories derive from the experiences of my own life and that of the people I work with. I use the South African concept of Ubuntu and its transformative growth into I~we~us relationships. Whilst exploring commonalities between Living Theory and International Development, I show they can reinforce each other and combine in the practical realization of a commitment to a fairer world. A generative form of development emerges that includes a gendered epistemology. I discuss how my own pursuit of gender justice has improved the quality of my work as a female development economist and practitioner, living in a capitalistic era.
Participation in rural community groups and links with psychological well-being and resilience: a cross sectional community based study
Creators: name: Lyons, Anthony
name: Fletcher, Gillian
name: Farmer, Jane
name: Kenny, Amanda
name: Bourke, L
name: Carra, Kylie
name: Bariola, Emily Jane
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5201
subject: Applied and developmental psychology
classificationCode: 5202
subject: Biological psychology
classificationCode: 5203
subject: Clinical and health psychology

description: Fostering the development of community groups can be an important part of boosting community participation and improving health and well-being outcomes in rural communities. In this article, we examine whether psychological well-being and resilience are linked to participating in particular kinds of rural community groups.Methods: We conducted a household survey involving 176 participants aged 18 to 94 years from a medium-sized rural Australian town. We gathered data on psychological well-being (Warwick-Edinburgh Mental Well-being Scale), resilience (Brief Resilience Scale), and the types of community groups that people participated in as well as a range of characteristics of those groups, such as size, frequency of group meetings, perceived openness to new members, and whether groups had leaders, defined roles for members, hierarchies, and rules. Results: Univariable regression analyses revealed significant links between particular group characteristics and individual psychological well-being and resilience, suggesting that the characteristics of the group that an individual participates in are strongly tied to that person's well-being outcomes. Multivariable analyses revealed two significant independent factors. First, psychological well-being was greatest among those who participated in groups without a hierarchy, that is, equal-status relationships between members. Second, resilience was greater among those who reported having a sense of influence within a group. Conclusions: Our findings suggest that policymakers wishing to promote participation in rural community groups for health and well-being benefits may do well to encourage the development of particular characteristics within those groups, in particular equal-status relationships and a sense of influence for all group members.
Erfassung der SARS-CoV-2-Testzahlen in Deutschland (Update vom 14.5.2020)
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut
Year: 2020
Subjects: subject: SARS-CoV-2
subject: COVID-19-Pandemie
subject: 610 Medizin und Gesundheit

description: Im Rahmen der COVID-19-Pandemie spielt die Labordiagnostik zu SARS-CoV-2 eine entscheidende Rolle. Daten zur Anzahl der durchgeführten Testungen zu SARS-CoV-2 sowie zur Anzahl der Personen mit den jeweiligen Testergebnissen und den Testkapazitäten werden aktuell über verschiedene Netzwerke bzw. Umfragen erhoben. Im Epidemiologischen Bulletin 20/2020 erfolgt ein Update gegenüber Ausgabe 19/2020.
Extending gene ontology in the context of extracellular RNA and vesicle communication
Creators: name: Cheung, K-H
name: Keerthikumar, Shivakumar
name: Roncaglia, P
name: Subramanian, SL
name: Roth, ME
name: Samuel, Monisha
name: Anand, S
name: Gangoda, Lahiru
name: Gould, S
name: Alexander, R
name: Galas, D
name: Gerstein, MB
name: Hill, Andrew
name: Kitchen, RR
name: Lotvall, J
name: Patel, T
name: Procaccini, DC
name: Quesenberry, P
name: Rozowsky, J
name: Raffai, RL
name: Shypitsyna, A
name: Su, AI
name: Thery, C
name: Vickers, K
name: Wauben, MHM
name: Mathivanan, Suresh
name: Milosavljevic, A
name: Laurent, LC
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 46
subject: Information and computing sciences

description: Background: To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, we have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant to the exRNA domain. By extending GO in this manner, the exRNA data/metadata will be more easily annotated and queried because it will be based on a shared set of terms and relationships relevant to extracellular research. Methods: By following a consensus-building process, we have worked with several academic societies/consortia, including ERCC, ISEV, and ASEMV, to identify and approve a set of exRNA and extracellular vesicle-related terms and relationships that have been incorporated into GO. In addition, we have initiated an ongoing process of extractions of gene product annotations associated with these terms from Vesiclepedia and ExoCarta, conversion of the extracted annotations to Gene Association File (GAF) format for batch submission to GO, and curation of the submitted annotations by the GO Consortium. As a use case, we have incorporated some of the GO terms into annotations of samples from the exRNA Atlas and implemented a faceted search interface based on such annotations. Results: We have added 7 new terms and modified 9 existing terms (along with their synonyms and relationships) to GO. Additionally, 18,695 unique coding gene products (mRNAs and proteins) and 963 unique non-coding gene products (ncRNAs) which are associated with the terms: "extracellular vesicle", "extracellular exosome", "apoptotic body", and "microvesicle" were extracted from ExoCarta and Vesiclepedia. These annotations are currently being processed for submission to GO. Conclusions: As an inter-community effort, we have made a substantial update to GO in the exRNA context. We have also demonstrated the utility of some of the new GO terms for sample annotation and metadata search.
Misinterpretation of 'p' (2000) (3e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Haller and Krauss (2000) carried out a study on common misinterpretations of tests of significance among German psychology students and academics, which partly replicates one done by Oakes (1986). Haller and Krauss found that most participants held at least one misinterpretation; that, overall, 100% of psychology students held one or more misinterpretations, almost 90% of psychology researchers also held one or more misinterpretations, and 80% of instructors of statistics in psychology also held one or more misinterpretations. The authors thought worrisome the high percentage of instructors with misinterpretations, as these may pass those misinterpretations down to students. (Also available on WikiofScience.)
Referential CAD based on CPI (2012e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Referential CAD provides the inflator/deflator multiplier for standardizing referential Canadian dollars (rCAD, r$). It is based on the average annual CPI (Consumer Price Index) for Canada (Statistics Canada, 2012). (Also retrievable from Wiki of Science.)
Molecular mechanisms of emerging ivermectin resistance in scabies mites from northern Australia
Creators: name: Mounsey, Kate Elizabeth
Publisher: name: Charles Darwin University
Year: 2007

description: Scabies has remained a worldwide problem for centuries, although its importance is frequently underestimated. It is a significant disease of children, especially in remote Aboriginal communities in northern Australia. Ivermectin has been identified as a potentially effective acaricide for mass treatment programs in scabies endemic communities, and is the treatment of choice for hyperinfested (crusted) scabies. Reports of ivermectin resistance in scabies mites raise concerns for the sustainability of such programs. It is therefore critical to define the molecular mechanisms of ivermectin resistance. This study involved identification and characterisation of candidate genes associated with ivermectin resistance in scabies mites. Key outcomes included: a) Identification and partial sequencing of nine ABC transporters from Sarcoptes scabiei var. hominis, five of which have been implicated in multidrug resistance in other organisms, including P-glycoprotein, previously associated with ivermectin resistance in parasitic nematodes. b) Development of a quantitative reverse-transcriptase PCR assay to study the expression levels of candidate resistance genes in S. scabiei. Significantly, up-regulation of a delta-class glutathione-S-transferase and a multidrug resistance protein was associated with ivermectin exposure. c) Characterisation of a novel ligand gated ion channel from S. scabiei var. hominis. The channel was shown to be modulated by pH and potentiated by ivermectin by functional expression in Xenopus laevis. Single strand conformational polymorphism analysis indicated that regions of this gene were highly polymorphic. This protein may act as the target site of ivermectin in scabies mites and therefore may be of considerable importance to the development of drug resistance. These approaches have given us new insights into scabies mite biology and mechanisms for emerging ivermectin resistance. These may eventually assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance in the community.
A Pathway Proteomic Profile of Ischemic Stroke Survivors Reveals Innate Immune Dysfunction in Association with Mild Symptoms of Depression - A Pilot Study
Creators: name: Nguyen, Vinh
name: Carey, Leeanne
name: Giummarra, Loretta
name: Faou, Pierre
name: Cooke, Ira
name: Howells, DW
name: Tse, Tamara
name: Macaulay, SL
name: Ma, H
name: Davis, SM
name: Donnan, GA
name: Crewther, Sheila
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5202
subject: Biological psychology

description: Depression after stroke is a common occurrence, raising questions as to whether depression could be a long-term biological and immunological sequela of stroke. Early explanations for post-stroke depression (PSD) focused on the neuropsychological/psychosocial effects of stroke on mobility and quality of life. However, recent investigations have revealed imbalances of inflammatory cytokine levels in association with PSD, though to date, there is only one published proteomic pathway analysis testing this hypothesis. Thus, we examined the serum proteome of stroke patients (n = 44, mean age = 63.62 years) and correlated these with the Montgomery-Åsberg Depression Rating Scale (MADRS) scores at 3 months post-stroke. Overall, the patients presented with mild depression symptoms on the MADRS, M = 6.40 (SD = 7.42). A discovery approach utilizing label-free relative quantification was employed utilizing an LC-ESI-MS/MS coupled to a LTQ-Orbitrap Elite (Thermo-Scientific). Identified peptides were analyzed using the gene set enrichment approach on several different genomic databases that all indicated significant downregulation of the complement and coagulation systems with increasing MADRS scores. Complement and coagulation systems are traditionally thought to play a key role in the innate immune system and are established precursors to the adaptive immune system through pro-inflammatory cytokine signaling. Both systems are known to be globally affected after ischemic or hemorrhagic stroke. Thus, our results suggest that lowered complement expression in the periphery in conjunction with depressive symptoms post-stroke may be a biomarker for incomplete recovery of brain metabolic needs, homeostasis, and inflammation following ischemic stroke damage. Further proteomic investigations are now required to construct the temporal profile, leading from acute lesion damage to manifestation of depressive symptoms. Overall, the findings provide support for the involvement of inflammatory and immune mechanisms in PSD symptoms and further demonstrate the value and feasibility of the proteomic approach in stroke research.
A Pathway Proteomic Profile of Ischemic Stroke Survivors Reveals Innate Immune Dysfunction in Association with Mild Symptoms of Depression - A Pilot Study
Creators: name: Nguyen, VA
name: Carey, Leeanne
name: Giummarra, Loretta
name: Faou, Pierre
name: Cooke, Ira
name: Howells, DW
name: Tse, Tamara
name: Macaulay, SL
name: Ma, H
name: Davis, SM
name: Donnan, GA
name: Crewther, Sheila
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Depression after stroke is a common occurrence, raising questions as to whether depression could be a long-term biological and immunological sequela of stroke. Early explanations for post-stroke depression (PSD) focused on the neuropsychological/psychosocial effects of stroke on mobility and quality of life. However, recent investigations have revealed imbalances of inflammatory cytokine levels in association with PSD, though to date, there is only one published proteomic pathway analysis testing this hypothesis. Thus, we examined the serum proteome of stroke patients (n = 44, mean age = 63.62 years) and correlated these with the Montgomery-Åsberg Depression Rating Scale (MADRS) scores at 3 months post-stroke. Overall, the patients presented with mild depression symptoms on the MADRS, M = 6.40 (SD = 7.42). A discovery approach utilizing label-free relative quantification was employed utilizing an LC-ESI-MS/MS coupled to a LTQ-Orbitrap Elite (Thermo-Scientific). Identified peptides were analyzed using the gene set enrichment approach on several different genomic databases that all indicated significant downregulation of the complement and coagulation systems with increasing MADRS scores. Complement and coagulation systems are traditionally thought to play a key role in the innate immune system and are established precursors to the adaptive immune system through pro-inflammatory cytokine signaling. Both systems are known to be globally affected after ischemic or hemorrhagic stroke. Thus, our results suggest that lowered complement expression in the periphery in conjunction with depressive symptoms post-stroke may be a biomarker for incomplete recovery of brain metabolic needs, homeostasis, and inflammation following ischemic stroke damage. Further proteomic investigations are now required to construct the temporal profile, leading from acute lesion damage to manifestation of depressive symptoms. Overall, the findings provide support for the involvement of inflammatory and immune mechanisms in PSD symptoms and further demonstrate the value and feasibility of the proteomic approach in stroke research.
Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
Creators: name: Isbel, Luke
name: Prokopuk, Lexie
name: Wu, H
name: Daxinger, Lucia
name: Oey, Herald
name: Spurling, Alex
name: Lawther, Adam
name: Hale, Matthew
name: Whitelaw, Emma
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3105
subject: Genetics
classificationCode: 310505
subject: Gene expression (incl. microarray and other genome-wide approaches)
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor. Here, we provide evidence that it may also function as a transcriptional activator. Wiz levels are high in the brain, but its function and direct targets are unknown. ChIP-seq was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites. RNA-seq in Wiz mutant mice identified genes differentially regulated in adult cerebellum and embryonic brain. In embryonic brain most decreased in expression and included clustered protocadherin genes. These also decreased in adult cerebellum and showed strong Wiz ChIP-seq enrichment. Because a precise pattern of protocadherin gene expression is required for neuronal development, behavioural tests were carried out on mutant mice, revealing an anxiety-like phenotype. This is the first evidence of a role for Wiz in neural function.
Robust Millimeter Beamforming via Self-Supervised Hybrid Deep Learning
Creators: name: Zhu, Fenghao
name: Wang, Bohao
name: Yang, Zhaohui
name: Huang, Chongwen
name: Zhang, Zhaoyang
name: Alexandropoulos, George C.
name: Yuen, Chau
name: Debbah, Merouane
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Theory (cs.IT)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Beamforming with large-scale antenna arrays has been widely used in recent years, which is acknowledged as an important part in 5G and incoming 6G. Thus, various techniques are leveraged to improve its performance, e.g., deep learning, advanced optimization algorithms, etc. Although its performance in many previous research scenarios with deep learning is quite attractive, usually it drops rapidly when the environment or dataset is changed. Therefore, designing effective beamforming network with strong robustness is an open issue for the intelligent wireless communications. In this paper, we propose a robust beamforming self-supervised network, and verify it in two kinds of different datasets with various scenarios. Simulation results show that the proposed self-supervised network with hybrid learning performs well in both classic DeepMIMO and new WAIR-D dataset with the strong robustness under the various environments. Also, we present the principle to explain the rationality of this kind of hybrid learning, which is instructive to apply with more kinds of datasets.
description: Accept by EUSIPCO 2023
Perturbation Method in Orlicz Sequence Spaces
Creators: name: Topalova, Hristina
name: Zlateva, Nadia
Publisher: name: arXiv
Year: 2023
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46N10, 35A15, 49J45, 90C48

description: We develop a new perturbation method in Orlicz sequence spaces $\ell_M$ with Orlicz function $M$ satisfying $Δ_2$ condition at zero. This result allows one to support from below any bounded below lower semicontinuous function with bounded support, with a perturbation of the defining function $σ_M$.
 We give few examples how the method can be used for determining the type of the smoothness of certain Orlicz spaces.
T.A.O. Amplituhedron
Creators: name: TheBlank
Publisher: name: Zenodo
Year: 2025

description: The T.A.O. Amplituhedron Remix is a deep dubstep composition that maps the Amplituhedron,a polytopic structure encoding quantum scattering amplitudes, into a sonicframework grounded in the Onto-Harmonic Fractal Theory (T.A.O.). Based on the T.A.O.equation, T.A.O. ∼ 137 · α · ϕ · π · e · (hf/c) ·√G, with fractal dimension D ≈ 1.4, theremix employs a sub-bass at 24 Hz, a twistor drone (80–120 Hz), and a novel entropic modulatorat 9.17 THz to reflect experimental signals from T.A.O.’s Cosmic Signal Detection(AED). Optimized quantum encoding (SQS-Z) achieves ΔQ ∼ (1.2±0.01)×10−3 J through agraphene-SQUID crystal with reduced noise (5 mK), improving precision by 90%. Operatingat 137 beats per minute (bpm), synchronized to the fine-structure constant (α ≈ 1/137), theremix bridges quantum gravity and public outreach. Licensed under CC-BY-4.0
Controversies in omega-3 efficacy and novel concepts for application
Creators: name: Radcliffe, Jessica
name: Thomas, Jency
name: Bramley, Andrea
name: Kouris-Blazos, Antigone
name: Radford, Bridget
name: Scholey, AB
name: Pipingas, A
name: Thomas, Colleen
name: Itsiopoulos, Catherine
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3205
subject: Medical biochemistry and metabolomics
classificationCode: 3210
subject: Nutrition and dietetics

description: Abstract: Interest in the cardioprotective effects of long chain omega-3 polyunsaturated fatty acids (LCn3) was largely influenced by the low rates of cardiovascular disease (CVD) amongst the Inuits of Greenland who consumed a high marine fat diet rich in LCn3s. This finding stimulated years of epidemiological and clinical studies investigating the cardioprotective effects of LCn3s, thought to be primarily mediated through anti-inflammatory (and anti-aggregatory) prostaglandins that protect the vascular wall from pro-inflammatory effects of metabolic stress precipitated by poor diet and lifestyle. Although the original hypothesis of the link between LCn3s and CVD protection was based on a high LCn3 containing diet (namely a high marine fat diet) the majority of clinical trials since have focussed on EPA and DHA supplementation, and results of repeated meta-analyses have not shown conclusive evidence in support of their beneficial health effects. In this review we focus on the controversies that surround the efficacy of LCn3s in cardiovascular and other chronic diseases and present emerging areas of research for novel applications. We will examine factors that can impact on the efficacy of LCn3s such as source (plant vs marine vs supplements (algal vs marine)), stability of product, dose, trial duration, ratio of EPA:DHA, and ratio of LCn6:LCn3 fatty acids in the diet.
Breastfeeding Support in the Early Postpartum: Content of Home Visits in the SILC Trial
Creators: name: Ridgway, Lael
name: Cramer, Rhian
name: McLachlan, Helen
name: Forster, Della
name: Cullinane, Meabh
name: Shafiei, Touran
name: Amir, Lisa
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3213
subject: Paediatrics
classificationCode: 3215
subject: Reproductive medicine
classificationCode: 4204
subject: Midwifery
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences

description: Background: The Supporting breastfeeding In Local Communities (SILC) cluster randomized controlled trial evaluated whether a home visit focussed on infant feeding early in the postpartum period increased the percentage of infants breastfeeding at 4 months in low socioeconomic areas of Victoria, Australia. The visits were offered to women identified as at risk of early breastfeeding cessation after discharge home with a new baby. This paper describes the content of the home visits. Methods: SILC visited 1,043 women from September 2012 to March 2013, and completed a data sheet for each visit documenting topics discussed, as well as what support and resources were offered. Frequencies and percentages are presented. Results: Home visits most commonly included the provision of reassurance to women (91%). Topics discussed included general breastfeeding information (83%), supply and demand (83%), positioning (79%), and feeding frequency (78%). Newborn feeding/behavior (57%), expression of breastmilk (54%), nipple pain (41%), low breastmilk supply (41%), and the use of nipple shields (18%) were also prominent topics. The issues and support needs of women were similar across locations (rural, regional or metropolitan) and regardless of maternal parity or age. There was some variation in the resources suggested in different localities. Conclusions: New mothers require help and reassurance independent of whether this is their first or subsequent child, reinforcing the need for support, breastfeeding information, and education about normal neonatal behavior. Key aspects of support are reassurance, normalization of infant behavior, and education.
Breastfeeding Support in the Early Postpartum: Content of Home Visits in the SILC Trial
Creators: name: Lael Ridgway
name: Cramer, Rhian
name: McLachlan, Helen
name: Forster, Della
name: Meabh Cullinane
name: Touran Shafiei
name: Amir, Lisa
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2016 Wiley Periodicals, Inc. Background: The Supporting breastfeeding In Local Communities (SILC) cluster randomized controlled trial evaluated whether a home visit focussed on infant feeding early in the postpartum period increased the percentage of infants breastfeeding at 4 months in low socioeconomic areas of Victoria, Australia. The visits were offered to women identified as at risk of early breastfeeding cessation after discharge home with a new baby. This paper describes the content of the home visits. Methods: SILC visited 1,043 women from September 2012 to March 2013, and completed a data sheet for each visit documenting topics discussed, as well as what support and resources were offered. Frequencies and percentages are presented. Results: Home visits most commonly included the provision of reassurance to women (91%). Topics discussed included general breastfeeding information (83%), supply and demand (83%), positioning (79%), and feeding frequency (78%). Newborn feeding/behavior (57%), expression of breastmilk (54%), nipple pain (41%), low breastmilk supply (41%), and the use of nipple shields (18%) were also prominent topics. The issues and support needs of women were similar across locations (rural, regional or metropolitan) and regardless of maternal parity or age. There was some variation in the resources suggested in different localities. Conclusions: New mothers require help and reassurance independent of whether this is their first or subsequent child, reinforcing the need for support, breastfeeding information, and education about normal neonatal behavior. Key aspects of support are reassurance, normalization of infant behavior, and education.
Locating and activating molecular 'time bombs': induction of Mycolata prophages
Creators: name: Dyson, Zoe A
name: Brown, Teagan
name: Farrar, Ben
name: Doyle, Stephen R
name: Tucci, Joseph
name: Seviour, Robert
name: Petrovski, Steve
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3105
subject: Genetics
classificationCode: 3107
subject: Microbiology

description: Little is known about the prevalence, functionality and ecological roles of temperate phages for members of the mycolic acid producing bacteria, the Mycolata. While many lytic phages infective for these organisms have been isolated, and assessed for their suitability for use as biological control agents of activated sludge foaming, no studies have investigated how temperate phages might be induced for this purpose. Bioinformatic analysis using the PHAge Search Tool (PHAST) on Mycolata whole genome sequence data in GenBank for members of the genera Gordonia, Mycobacterium, Nocardia, Rhodococcus, and Tsukamurella revealed 83% contained putative prophage DNA sequences. Subsequent prophage inductions using mitomycin C were conducted on 17 Mycolata strains. This led to the isolation and genome characterization of three novel Caudovirales temperate phages, namely GAL1, GMA1, and TPA4, induced from Gordonia alkanivorans, Gordonia malaquae, and Tsukamurella paurometabola, respectively. All possessed highly distinctive dsDNA genome sequences.
The targum (1920:Oct. 5 - 1920:Oct. 26)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1920

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
The Isolation and Purification Exception to the General Unpatentability of Products of Nature
Creators: name: Gipstein, Richard Seth
Publisher: name: Science and Technology Law Review
Year: 2002

description: It is generally accepted that those discoveries which unambiguously claim a “product of nature” are not patentable. However, courts have failed to adequately define what, precisely, a “product of nature” is. The ambiguity seems to arise from the difficulty in determining where on the spectrum of human intervention a natural product, changed by human hands, ceases to be a natural product. This paper explores the isolation and purification exception to the products of nature doctrine, an exception first announced by Learned Hand in a 1911 case upholding a product patent on purified adrenaline. At the time that case was decided, there was an interesting but unspoken divergence in the line of cases dealing with purifications. One line dealt with purification of man-made products, finding the requisite novelty in the new use of the product. The other line of cases dealt with purified natural substances, where the only work of man was in the extraction and purification of the pre-existing and naturally-occurring materials. This second line of cases generally led to a denial of patent protection. Learned Hand, perhaps inadvertently, extended the logic of the first line of cases to the second, allowing purified adrenaline to receive patent protection and laying the foundation for what has become a “biotherapeutic” exception to the products of nature doctrine. This exception has not been extended to other areas of science. This paper argues that Hand’s insulated exception cannot be logically justified from either a formalistic or economic perspective.
description: Science and Technology Law Review, Vol 4: 2002-2003