cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Kontrol'nye spiski dlja izucenija i ocenki sostojanija promyslennych ob'ektov s opasnymi dlja vody vescestvami i preparatami v celljulozno-bumaznoj promyslennosti
title: Контрольный список № ЦТ. 3: Варка целлюлозы
titleType: AlternativeTitle
Creators: name: Winkelmann-Oei, Gerhard
Publisher: name: My University
Year: 2016
Subjects: subject: Papierindustrie
subject: Zellstoffindustrie
subject: Gewässerschutz
subject: Wasserverunreinigung
subject: Risikomanagement
subject: Leitfaden
subject: paper industry
subject: pulp industry
subject: pulp production
subject: water protection
subject: water pollution
subject: water pollutants
subject: risk management
subject: checklist
subject: guideline
subject: Chemikalien
subject: Chemicals

description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren. Quelle: Bericht
description: Эти отраслевые контрольные листы представляют собой руководство по проверке и оценке состояния установок с вредными для водных ресурсов материалами и растворами в целлюлозно-бумажной промышленности. При этом они предлагают обзор различных сфер деятельности, а также сферы, разделенной по производственным отраслям, для идентификации потенциальных источников риска и целей модернизации.
Three-dimensional tomography of the galactic and extragalactic magnetoionic medium with the SKA
Creators: name: Han, J. L.
name: van Straten, Willem
name: Lazio, T. J W
name: Deller, Adam
name: Sobey, C.
name: Xu, J.
name: Schnitzeler, D. H F M
name: Imai, H.
name: Chatterjee, S.
name: Macquart, Jean Pierre
name: Kramer, M.
name: Cordes, J.
Publisher: name: Swinburne
Year: 2024

description: The magneto-ionic structures of the interstellar medium of the Milky Way and the intergalactic
medium are still poorly understood, especially at distances larger than a few kiloparsecs from the
Sun. The three-dimensional (3D) structure of the Galactic magnetic field and electron density distribution may be probed through observations of radio pulsars, primarily owing to their compact
nature, high velocities, and highly-polarized short-duration radio pulses. Phase 1 of the SKA, i.e.
SKA1, will increase the known pulsar population by an order of magnitude, and the full SKA, i.e.
SKA2, will discover pulsars in the most distant regions of our Galaxy. SKA1-VLBI will produce
model-independent distances to a large number of pulsars, and wide-band polarization observations
by SKA1-LOW and SKA1-MID will yield high precision dispersion measure, scattering measure, and rotation measure estimates along thousands of lines of sight. When combined, these observations will enable detailed tomography of the large-scale magneto-ionic structure of both the Galactic disk and the Galactic halo. Turbulence in the interstellar medium can be studied through the variations of these observables and the dynamic spectra of pulsar flux densities. SKA1-LOW and SKA1-MID will monitor interstellar weather and produce sensitive dynamic and secondary spectra of pulsar scintillation, which can be used to make speckle images of the ISM, study turbulence on scales between ∼ 108 and 1013 m, and probe pulsar emission regions on scales down to ∼10 km. In addition, extragalactic pulsars or fast radio bursts to be discovered by SKA1 and SKA2 can be used to probe the electron density distribution and magnetic fields in the intergalactic medium beyond the MilkyWay.
The Hero's Journey in Player Experiences
Creators: name: Moran, Jacqueline
Publisher: name: Swinburne
Year: 2024

description: The Hero's Journey is a popular and influential storytelling tool, but the version adopted into digital games is a simplified fraction of Joseph Campbell's more dynamic and nuanced original. This thesis adds to the existing literature by examining Campbell's Hero's Journey as a tool for analysing player experiences. Detailed accounts of six participants' experiences playing two critically acclaimed videogames were combined with theories of motivation, affordances, and narrative to analyse and modify Campbell's original Hero's Journey. The result is a more flexible, modular, and phenomenological Ludic Hero's Journey.
LARR: Large Language Model Aided Real-time Scene Recommendation with Semantic Understanding
Creators: name: Wan, Zhizhong
name: Yin, Bin
name: Xie, Junjie
name: Jiang, Fei
name: Li, Xiang
name: Lin, Wei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Information Retrieval (cs.IR)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Click-Through Rate (CTR) prediction is crucial for Recommendation System(RS), aiming to provide personalized recommendation services for users in many aspects such as food delivery, e-commerce and so on. However, traditional RS relies on collaborative signals, which lacks semantic understanding to real-time scenes. We also noticed that a major challenge in utilizing Large Language Models (LLMs) for practical recommendation purposes is their efficiency in dealing with long text input. To break through the problems above, we propose Large Language Model Aided Real-time Scene Recommendation(LARR), adopt LLMs for semantic understanding, utilizing real-time scene information in RS without requiring LLM to process the entire real-time scene text directly, thereby enhancing the efficiency of LLM-based CTR modeling. Specifically, recommendation domain-specific knowledge is injected into LLM and then RS employs an aggregation encoder to build real-time scene information from separate LLM's outputs. Firstly, a LLM is continual pretrained on corpus built from recommendation data with the aid of special tokens. Subsequently, the LLM is fine-tuned via contrastive learning on three kinds of sample construction strategies. Through this step, LLM is transformed into a text embedding model. Finally, LLM's separate outputs for different scene features are aggregated by an encoder, aligning to collaborative signals in RS, enhancing the performance of recommendation model.
3883827.pdf
Creators: name: Singh, Anshuman
name: li, Qing
name: Liu, Shunfa
name: Yu, Ying
name: Lu, Xiyuan
name: Schneider, Christian
name: Höfling, Sven
name: Lawall, John
name: Verma, Varun
name: Mirin, Richard
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplementary Information
Effect of different shades and designs of facial scan markers on accuracy of the 3-dimensional virtual patient representation
Creators: name: Shareef, Hiba
Publisher: name: University of Iowa
Year: 2025

description: This study observed the effect of different shade of facial scan markers on the trueness and precision of 3D virtual patient representation, which is created by superimposition procedure between facial scans and intra-oral scans. The secondary aim was to determine whether the different designs (Spherical and Rectangular) had any significant effect on integration accuracy. Ten different combinations of extraoral scan markers were tested: A1 Spherical, A1 Rectangular, A2 Spherical, A2 Rectangular, A3 Spherical, A3 Rectangular, White Spherical, White Rectangular, Gray Spherical and Gray Rectangular.
description: With different digitization methods and a facial scan, results showed that the most reliable shade to use for extraoral scan markers to achieve ideal measurements in terms of trueness and precision were the grey scan markers, showing the least amount of deviation from the control group measurements, which were completed without the placement of an extraoral scan marker. The extraoral scan markers that were designed with Spherical design also showed a greater trueness and precision when compared to the scan markers designed with rectangular design. Measurements showed that the second most accurate scan marker shade was the A1, also showing superior trueness and precision with the spherical design. The scan marker 3D printed in white resin, with a rectangular design showed the lowest trueness and precision, making not a suitable shade nor design for prostheses planning that utilizes facial scanning technology.
ORANCHADA visual guide (Widget usage examples)
Creators: name: Kochev, Nikolay
name: Tancheva, Gergana
name: Tsoneva, Slava
name: Tsokova, Gergana
name: Georgiev, Georgi
name: Iliev, Luchesar
name: Jeliazkova, Nina
Publisher: name: Zenodo
Year: 2023
Subjects: Raman spectra, harmonization, calibration, Python, Orange workflow, open source

description: This is a user guide for the Oranchada software package, an Orange add-on , providing user friendly access to ramanchada2 Python package for Raman spectra harmonisation and calibration workflows. The Oranchada package is open source and MIT-licensed and actively developed at https://github.com/h2020charisma/oranchada. The ramanchada2, is an open-source,MIT-licensed,Python package available at https://github.com/h2020charisma/ramanchada2
 Oranchada and Ramanchada2 is published at the Python Package Index repository (PyPI).
Testing gravity with Pulsars in the SKA Era
Creators: name: Shao, Lijing
name: Stairs, I. H.
name: Antoniadis, John
name: Deller, Adam
name: Freire, P. C C
name: Hessels, Jason W T
name: Janssen, G. H.
name: Kramer, M.
name: Kunz, Jutta
name: Lämmerzahl, Claus
name: Perlick, Volker
name: Possenti, A.
name: Ransom, S. M.
name: Stappers, B.
name: van Straten, Willem
Publisher: name: Swinburne
Year: 2024

description: The Square Kilometre Array (SKA) will use pulsars to enable precise measurements of strong
gravity effects in pulsar systems, which yield tests of gravitational theories that cannot be carried
out anywhere else. The Galactic census of pulsars will discover dozens of relativistic pulsar
systems, possibly including pulsar – black hole binaries which can be used to test the “cosmic
censorship conjecture” and the “no-hair theorem”. Also, the SKA’s remarkable sensitivity will
vastly improve the timing precision of millisecond pulsars, allowing probes of potential deviations
from general relativity (GR). Aspects of gravitation to be explored include tests of strong
equivalence principles, gravitational dipole radiation, extra field components of gravitation, gravitomagnetism, and spacetime symmetries.
ORANCHADA visual guide (Widget usage examples)
Creators: name: Kochev, Nikolay
name: Tancheva, Gergana
name: Tsoneva, Slava
name: Tsokova, Gergana
name: Georgiev, Georgi
name: Iliev, Luchesar
name: Jeliazkova, Nina
Publisher: name: Zenodo
Year: 2024
Subjects: Raman spectra
calibration
harmonization
Python
Orange data mining
open source
Orange add on

description: This is a user guide for the Oranchada software package, an Orange add-on , providing user friendly access to ramanchada2 Python package for Raman spectra harmonisation and calibration workflows.

The Oranchada package is open source and MIT-licensed and actively developed at https://github.com/h2020charisma/oranchada.

The ramanchada2, is an open-source,MIT-licensed,Python package available at https://github.com/h2020charisma/ramanchada2
Oranchada and Ramanchada2 is published at the Python Package Index repository (PyPI).
CDKN2A founder mutation in pancreatic ductal adenocarcinoma patients without cutaneous features of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome
Creators: name: Cremin, Carol
name: Howard, Sarah
name: Le, Lyly
name: Karsan, Aly
name: Schaeffer, David F.
name: Renouf, Daniel J.
name: Schrader, Kasmintan A.
Publisher: name: BioMed Central
Year: 2018

description: Background: Approximately 5% to 10% of pancreatic ductal adenocarcinoma (PDAC) has a hereditary basis. In most of these defined hereditary cancer syndromes, PDAC is not the predominant cancer type. Traditional criteria for publicly funded genetic testing typically require the presence of a set combination of the predominant syndrome-associated cancer types in the family history. We report the identification of a CDKN2A pathogenic variant in a PDAC-prone family without the cutaneous features of multiple moles or melanoma that are characteristic of the Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome identified in a universal testing algorithm for inherited mutations in pancreatic cancer patients. Case presentation: We present the case of two brothers of English ancestry diagnosed with PDAC within the same 12 month period, at the respective ages of 63 and 64 years of age. Neither brother reported a personal history of multiple moles or melanoma. Family history was positive for two second-degree relatives diagnosed with PDAC but was negative for other cancers or multiple moles in first- and second-degree relatives. Due to the absence of melanoma, this family did not meet provincial criteria for publicly funded genetic testing. Clinical genetic testing offered through a research grant identified a pathogenic variant in the CDKN2A gene c.377 T > A (p.Val126Asp). This variant is a North American founder mutation believed to pre-date colonization. Conclusions: This case reminds clinicians to consider the possibility of a germline CDKN2A mutation in families with a high prevalence of PDAC, even in the absence of moles or melanoma. This case supports recent guidelines published by the American College of Medical Genetics and Genomics (ACMG) that genetics referrals are indicated in families with three or more cases of PDAC regardless of other cancer types in the family. A multi-gene panel approach is of particular benefit in diagnosing inherited cancer susceptibility in PDAC-only families.
Laser frequency combs for astronomical observations
Creators: name: Steinmetz, T.
name: Wilken, T.
name: Araujo-Hauck, C.
name: Holzwarth, R.
name: Hänsch, T. W.
name: Pasquini, L.
name: Manescau, A.
name: D'Odorico, S.
name: Murphy, Michael
name: Kentischer, T.
name: Schmidt, W.
name: Udem, Th
Publisher: name: Swinburne
Year: 2024

description: A direct measurement of the universe's expansion history could be made by observing in real time the evolution of the cosmological redshift of distant objects. However, this would require measurements of Doppler velocity drifts of ~1 centimeter per second per year, and astronomical spectrographs have not yet been calibrated to this tolerance. We demonstrated the first use of a laser frequency comb for wavelength calibration of an astronomical telescope. Even with a simple analysis, absolute calibration is achieved with an equivalent Doppler precision of ~9 meters per second at ~1.5 micrometers—beyond state-of-the-art accuracy. We show that tracking complex, time-varying systematic effects in the spectrograph and detector system is a particular advantage of laser frequency comb calibration. This technique promises an effective means for modeling and removal of such systematic effects to the accuracy required by future experiments to see direct evidence of the universe's putative acceleration.
title: Trendanalyse - eine Methode für Umweltforschung und -politik
title: Trendanalyse - eine Methode für Umweltforschung und -politik
titleType: AlternativeTitle
Creators: name: Keppner, Benno
name: Kahlenborn, Walter
name: Weiss, Daniel
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Umweltauswirkung
subject: Trendanalyse
subject: Technikfolgenabschätzung
subject: Foresight
subject: Methoden
subject: Umweltauswirkungen
subject: Nachhaltigkeit | Strategien | Internationales

description: Dieses Methodenpapier skizziert für die Umweltpolitik, wie das Instrument der "Trendanalyse" für die Untersuchung von umweltrelevanten Entwicklungen nutzbar gemacht werden kann. Durch Trendanalysen können die verschiedenen Facetten eines Trends beschrieben werden und diese systematisch hinsichtlich ihrer Wirkungen auf die Umwelt analysiert werden. Trendanalysen können so dazu beitragen, die Umweltpolitik im Sinne einer antizipativen Politikgestaltung handlungsfähig zu machen. Quelle: Forschungsbericht
description: This report outlines for environmental policy how the research method "trend analysis" can support the analysis of environmentally relevant developments. Trend analyses generally encompass the description of a trend and the systematic analysis of its impact on the environment. In this way, they can contribute to making environmental policy more effective and to shape trends in an anticipatory manner. Quelle: Forschungsbericht
description: Umweltpolitik steht vor der Aufgabe, im Sinne des Vorsorgeprinzips so früh wie möglich neue Umweltprobleme zu erkennen und zu lösen. Trends beschreiben neue Entwicklungen, die in allen Bereichen der Gesellschaft auftreten können und möglicherweise auch Auswirkungen auf die Umwelt haben. Ob und welche Auswirkungen das sind, ist zumeist erst einmal unklar, weil wissenschaftliche Untersuchungen noch fehlen. Das vorliegende Methodenpapier beschreibt ein Vorgehen, wie Trends, die keinen offensichtlichen Umweltbezug haben, so analysiert werden können, dass die komplexen, interdependenten und oft indirekten Auswirkungen auf die Umwelt systematisch erfasst und eingeschätzt werden können.
Primers: A solid-state alternative to explosive initiators
Creators: name: Lundgaard, Stefan
Publisher: name: Swinburne
Year: 2024

description: Controlled explosions are an important requirement for safe use of otherwise dangerous compounds. Airbags exist in every car, fireworks are seen during celebrations particularly for a new years eve celebration and demolition processes all use some form of explosive mixes. To prevent further potential hazard by using sensitive and very energetic explosives that require careful handling and processing, this work was performed to develop a semiconductor based device that substitutes explosive compounds. Two novel device avenues are investigated, one electrical and one optical. In this thesis, previous research is summarised, the fabrication process is detailed and analysed as well characterisation of the device during breakdown.
title: Catching light
title: concerto for alto saxophone and sinfonietta
titleType: Subtitle
Creators: name: Meier, Zachery S.
Publisher: name: University of Iowa
Year: 2024
Subjects: Alto Saxophone
Concerto

description: “Catching Light” is musical work for solo alto saxophone and chamber ensemble that explores the representation of light in three distinct ways: within a darkened storm, through crepuscular rays, and with the rising of the sun at dusk. Through quick melodic and rhythmic gestures in the first movement, cluster chord bursts of the second movement, and the orchestrated build of melodic and textural material of the final movement, I explore the saxophonist’s ability to act as a force of light working to find its way out of the darkness. This piece serves as a personal investigation of identity, revelation, and the composition process. Elements of the piece are continuously modified and stripped away throughout each movement, exposing the saxophone to new identities as a solo voice within the larger ensemble.
THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila – a systems biology study
Creators: name: Schulz, Christine
name: Lai, Xin
name: Bertrams, Wilhelm
name: Jung, Anna Lena
name: Sittka-Stark, Alexandra
name: Herkt, Christina Elena
name: Janga, Harshavadhan
name: Zscheppang, Katja
name: Stielow, Christina
name: Schulte, Leon
name: Hippenstiel, Stefan
name: Vera, Julio
name: Schmeck, Bernd
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Medical research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Immune response in the lung has to protect the huge alveolar surface against pathogens while securing the delicate lung structure. Macrophages and alveolar epithelial cells constitute the first line of defense and together orchestrate the initial steps of host defense. In this study, we analysed the influence of macrophages on type II alveolar epithelial cells during Legionella pneumophila-infection by a systems biology approach combining experimental work and mathematical modelling. We found that L. pneumophila-infected THP-1-derived macrophages provoke a pro-inflammatory activation of neighboring lung epithelial cells, but in addition render them hypo-responsive to direct infection with the same pathogen. We generated a kinetic mathematical model of macrophage activation and identified a paracrine mechanism of macrophage- secreted IL-1β inducing a prolonged IRAK-1 degradation in lung epithelial cells. This intercellular crosstalk may help to avoid an overwhelming inflammatory response by preventing excessive local secretion of pro- inflammatory cytokines and thereby negatively regulating the recruitment of immune cells to the site of infection. This suggests an important but ambivalent immunomodulatory role of macrophages in lung infection.
La cohérence du langage musical chez Debussy : une étude des rapports entre les éléments musicaux du deuxième mouvement du Quatuor à cordes, op. 10, no 1.
Creators: name: Corriveau, Martine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Music.

description: Selon certains commentateurs, entre autres Alan Street et Ruth Solie, l'unite organique represente, dans une certaine mesure, un critere incontournable en ce qu'on lui attribue une valeur esthetique dans le processus de l'analyse musicale. Au lieu de construire un discours ou la seule valeur de l'unite organique est prise en consideration, nous proposons, avec le concours de l'histoire, une serie de dechiffrements qui prend sa source dans les opinions esthetiques du compositeur. Ainsi, dans le cadre de cette etude, nous proposons trois determinations: premierement une presentation biographique et critique portant sur les protagonistes du symbolisme en France et sur l'influence que ceux-ci ont exercee sur les orientations esthetiques de Claude Debussy; deuxiemement une evaluation des effets du symbolisme germanique sur l'analyse appliquee contemporaine; troisiemement, un premier demontage analytique du deuxieme mouvement du Quatuor a cordes, op. 10, no 1 de Claude Debussy ou sont reprises a la fois les valeurs esthetiques du mode interpretatif organiciste et celles du symbolisme litteraire francais. La combinaison des approches interpretatives proposees permet de relever, dans le deuxieme mouvement du Quatuor a cordes, op. 10, no 1 de Claude Debussy, certaines valeurs esthetiques du symbolisme litteraire francais: les correspondances, l'ambiguite, le pluralisme dans l'interpretation et l'unite. La prise en consideration de ces valeurs, au cours de la procedure d'analyse musicale, n'engage pas a exclure l'unite organique. Il s'agit plutot de l'adjoindre aux autres valeurs esthetiques qui contribueront a etablir une nouvelle facon d'envisager le concept de coherence dans le cadre de l'analyse appliquee d'une oeuvre musicale.
On rings with the serial embedding property
Creators: name: Tang, Le
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract

description: The goal of this thesis is to study the embedding of modules into serial modules. It is well known that a ring is Artinian serial if and only if all its left modules are serial. Then the question of the existence of rings over which all left modules can be embedded in serial modules naturally arises. The study of this property was initiated by Tuganbaev. In this thesis, a ring $R$ is said to satisfy the (left) serial embedding property (S.E.P.) if every left $R$-module can be embedded in a serial $R$-module, while an $R$-module $M$ is said to satisfy the S.E.P. if $M$ is embeddable in a serial $R$-module.
description: This thesis consists of two major parts. In addition to providing alternative, conceptual proofs of some of Tuganbaev's results, in the first part, we further investigate the S.E.P. of rings for finite dimensional algebras, (noncommutative) domains, left semi-Artinian rings, Jacobson semisimple rings, local rings, and commutative rings. A commutative ring satisfies the S.E.P. if and only if it is a finite product of Artinian uniserial rings and discrete valuation rings. Using this premise, in the second part of this thesis, we study the S.E.P. of modules over two integral domains of Krull dimension one and describe a new characterization of Dedekind domains.
The Influence of Impact Mass, Inbound Velocity and System Compliance on the Dynamic Response of a Hybrid III Head Form
Creators: name: Coulson, Natalie R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Health Sciences, Recreation.

description: Sport helmet certification standards solely prescribe the use of vertical drop towers in their protocols; a mechanism which mimics the head impacting the ground. Athletes are more commonly injured via collisions with other players; however, and the current certification standards do not incorporate this mechanism of injury in their test methodologies. At the most basic level, these two injury mechanisms can be differentiated by impact mass. The purpose of this study was to determine the effect of impact mass on the dynamic response of a Hybrid III head form. This was carried out by impacting the front location of the un-helmeted head form over a range of inbound velocities (2.0 m/s, 3.0 m/s and 4.0 m/s) and system compliances (rigid neck, compliant neck and unrestrained head and neck) on two different test systems represented by impact mass (monorail vertical drop tower and horizontal linear impactor) to more completely characterize the relationship. Significant main effects and interactions were observed for impact mass, inbound velocity and system compliance on peak resultant translational acceleration and peak resultant rotational acceleration (p<0.05). Impacts on the monorail vertical drop tower (greater impact mass), resulted in higher acceleration values than the same impacts on the horizontal linear impactor, implying that the monorail generates more severe impacts. The greatest accelerations were also seen at the higher velocities, indicating that athletes impacted at higher velocities are at greater risk of suffering mild traumatic brain injury (mTBI). The relationship was non-linear for system compliance: the least compliant system generated the lowest translational accelerations, followed by the most compliant system, and ending with the intermediate level of system compliance. Rotational acceleration increased with increasing system compliance.
Disturbed Experience of Time in Depression - Evidence from Content Analysis
Creators: name: Vogel, David H. V.
name: Krämer, Katharina
name: Schoofs, Theresa
name: Kupke, Christian
name: Vogeley, Kai
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: epression
subject: time experience
subject: temporality
subject: phenomenological psychopathology
subject: content analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Disturbances in the experience of time have been a commonly reported feature of depressive disorders since the beginning of modern psychiatry and psychological research. However, qualitative research approaches to investigate the phenomenon are rarely used. We employed content analysis to investigate disturbances of time experience in Major Depressive Disorder. Our analysis from 25 participants showed that individuals with Major Depressive Disorder subjectively seem to have lost the ability to influence or change the present, resulting in an impersonal and blocked future. The present is rendered meaningless, the past unchangeably negative, and the passage of time turned into a dragging, inexorable, and viscous continuance. The overall,—possibly intersubjective—concept of time experience, remains largely intact, causing or adding to depressive mood and suffering. We elaborate on how these findings reflect previous theories on the experience of time in depression. This study might encourage future inquiries into both the phenomenal and neuroscientific foundation of time experience under psychopathological conditions.
CFHTLenS: The Canada-France-Hawaii telescope lensing survey - Imaging data and catalogue products
Creators: name: Erben, T.
name: Hildebrandt, H.
name: Miller, Lance
name: van Waerbeke, Ludovic
name: Heymans, Catherine
name: Hoekstra, H.
name: Kitching, Thomas
name: Mellier, Yannick
name: Benjamin, Jonathan
name: Blake, Chris
name: Bonnett, C.
name: Cordes, O.
name: Coupon, Jean
name: Fu, Liping
name: Gavazzi, R.
name: Gillis, B.
name: Grocutt, E.
name: Gwyn, S.
name: Holhjem, K.
name: Hudson, Michael J.
name: Kilbinger, Martin
name: Kuijken, Konrad
name: Milkeraitis, M.
name: Rowe, Barnaby
name: Schrabback, Tim
name: Semboloni, Elisabetta
name: Simon, P.
name: Smit, M.
name: Trader, O.
name: Vafaei, Sanaz
name: Van Uitert, E.
name: Velander, Malin
Publisher: name: Swinburne
Year: 2024

description: We present data products from the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS). CFHTLenS is based on the Wide component of the Canada-France-Hawaii Telescope Legacy Survey (CFHTLS). It encompasses 154 deg(2) of deep, optical, high-quality, sub-arcsecond imaging data in the five optical filters u*g(')r(')i(')z('). The scientific aims of the CFHTLenS team are weak gravitational lensing studies supported by photometric redshift estimates for the galaxies. This paper presents our data processing of the complete CFHTLenS data set. We were able to obtain a data set with very good image quality and high-quality astrometric and photometric calibration. Our external astrometric accuracy is between 60 and 70 mas with respect to Sloan Digital Sky Survey (SDSS) data, and the internal alignment in all filters is around 30 mas. Our average photometric calibration shows a dispersion of the order of 0.01-0.03 mag for g(')r(')i(')z(') and about 0.04 mag for u* with respect to SDSS sources down to i(SDSS) < 21. We demonstrate in accompanying papers that our data meet necessary requirements to fully exploit the survey for weak gravitational lensing analyses in connection with photometric redshift studies. In the spirit of the CFHTLS, all our data products are released to the astronomical community via the Canadian Astronomy Data Centre athttp://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/community/CFHTLens/query.html. We give a description and how-to manuals of the public products which include image pixel data, source catalogues with photometric redshift estimates and all relevant quantities to perform weak lensing studies.
Abundance, community composition, and site structure of lotic assemblages in Gatineau Park streams and streams in the Ottawa-Gatineau Region
Creators: name: Hamilton, Liza
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Ecology.
subject: Biology, Limnology.

description: Sixty-seven sample sites in 45 streams across the National Capital Region and Gatineau Park were sampled between the summers of 2001 and 2008 in order to describe communities within the Park and assess differences in stream fish and invertebrate assemblages along a gradient of urbanization. Additionally the relationships between nutrient concentration and biomass of algae, invertebrates, and fish were quantified, and changes in the size distribution of benthic invertebrates and fish along a gradient of nutrient and anthropogenic impacts were described. Principal Component Analyses indicated that urban and agricultural sites were easily distinguished from forested sites using water quality parameters. Invertebrate and fish assemblages did not differ as clearly among site categories. There were increased nutrient levels in agricultural and urbanized watersheds, however the biomass of primary producers did not proportionally track the increase in nutrients. Slopes of the relationships between biomass and nutrient concentration declined with increasing trophic level, indicating a reduction of the efficiency of energy transfer in more eutrophic systems. Size spectra from nitrogen enriched streams had elevated intercepts and increased residual variance was noted in perturbed watersheds. The current study has provided baseline data for stream communities within and outside of Gatineau Park and in doing so it is clear that Gatineau Park streams are in good, but variable health. In order to monitor change, protect diversity within the Park, and mitigate further stress to these streams, it may be useful to use aspects of the size spectra such as normalized density and the residual variance.
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy
Creators: name: Altmuueller, Franziska
name: Pothula, Santosh
name: Annamneedi, Anil
name: Nakhei-Rad, Saeideh
name: Montenegro-Venegas, Carolina
name: Marini, Claudia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Noonan syndrome (NS) is characterized by reduced growth, craniofacial abnormalities, congenital heart defects, and variable cognitive deficits. NS belongs to the RASopathies, genetic conditions linked to mutations in components and regulators of the Ras signaling pathway. Approximately 50% of NS cases are caused by mutations in PTPN11. However, the molecular mechanisms underlying cognitive impairments in NS patients are still poorly understood. Here, we report the generation and characterization of a new conditional mouse strain that expresses the overactive Ptpn11D61Y allele only in the forebrain. Unlike mice with a global expression of this mutation, this strain is viable and without severe systemic phenotype, but shows lower exploratory activity and reduced memory specificity, which is in line with a causal role of disturbed neuronal Ptpn11 signaling in the development of NS-linked cognitive deficits. To explore the underlying mechanisms we investigated the neuronal activity-regulated Ras signaling in brains and neuronal cultures derived from this model. We observed an altered surface expression and trafficking of synaptic glutamate receptors, which are crucial for hippocampal neuronal plasticity. Furthermore, we show that the neuronal activity-induced ERK signaling, as well as the consecutive regulation of gene expression are strongly perturbed. Microarray-based hippocampal gene expression profiling revealed profound differences in the basal state and upon stimulation of neuronal activity. The neuronal activity-dependent gene regulation was strongly attenuated in Ptpn11D61Y neurons. In silico analysis of functional networks revealed changes in the cellular signaling beyond the dysregulation of Ras/MAPK signaling that is nearly exclusively discussed in the context of NS at present. Importantly, changes in PI3K/AKT/mTOR and JAK/STAT signaling were experimentally confirmed. In summary, this study uncovers aberrant neuronal activity-induced signaling and regulation of gene expression in Ptpn11D61Y mice and suggests that these deficits contribute to the pathophysiology of cognitive impairments in NS.
Refined Estimates of Net Community Production in the Subarctic Northeast Pacific Derived From ΔO₂/Ar Measurements With N₂O-Based Corrections for Vertical Mixing
Creators: name: Izett, Robert W.
name: Manning, Cara C.
name: Hamme, Roberta C.
name: Tortell, Philippe Daniel, 1972-
Publisher: name: The University of British Columbia
Year: 2018

description: We present the first field application of a N₂O-based approach to correct for vertical mixing in the estimation of net community production (NCP) from mixed layer O₂ measurements. Using new ship-based observations of N₂O and biological oxygen saturation anomalies (ΔO₂/Ar) from the Subarctic Northeast Pacific, we provide refined mixed layer NCP estimates across contrasting hydrographic regimes and a comprehensive assessment of the methodological considerations and limitations of the approach. Increased vertical mixing coefficients at the base of the mixed layer, derived using N₂O measurements, corresponded with periods of heightened wind speed and coastal upwelling. Corrections were most significant in coastal regions where the vertical supply of low-O₂ water can otherwise falsely imply net heterotrophy from negative ΔO₂/Ar measurements. After correcting for the mixing flux, all coastal stations showed autotrophic signatures, with maximum NCP exceeding 100 mmol O₂ m⁻² d⁻¹ in the spring and summer. Vertical fluxes were lower in off-shelf waters but often contributed more than 50% to corrected NCP. At some oceanic stations, however, the cooccurrence of N₂O minima and O₂ maxima resulted in biased (overestimated) N₂O corrections. Evaluating vertical fluxes in these regions remains a challenge for ship-based studies. Nonetheless, our refined NCP estimates show better coherence with surface chlorophyll, temperature, and mixed layer depth than uncorrected values. Potential mixed layer N₂O production introduces some uncertainty in the approach, but errors are likely to be small. Ultimately, this work provides rationale for the adoption of the N₂O correction to refine NCP estimates, particularly in coastal waters.
Long wavelength emissions of periodic yard-glass shaped boron nitride nanotubes
Creators: name: Chen, Zhi Gang
name: Zou, J.
name: Liu, Gang
name: Li, Feng
name: Cheng, Hui Ming
name: Sekiguchi, Takashi
name: Gu, Min
name: Yao, Xiang Dong
name: Wang, Lianzhou
name: Lu, Gao Qing
Publisher: name: Swinburne
Year: 2024

description: Extraordinary and stable long wavelength emission (centered at ~685 nm) from the yard-glass shaped boron nitride nanotubes (YG-BNNTs) was observed in their cathodoluminescence and photoluminescence spectroscopy. The mechanism for this near-red light emission at ~685 nm is attributed to the periodical nature of the BNNT units with regular lattice defects. The visible-light emission from YG-BNNTs indicates that this material has great potential for applications as nano-optical and/or nano-optoelectronic devices in nanoscale surgery and spectroscopy.
Music Therapy Improves the Symptoms of Alzheimer's Disease and Dementia: A Magnetoencephalography Study of Cognitively Intense Music Therapy Doctor
Creators: name: Slade, Benjamin Michael
Publisher: name: Swinburne
Year: 2024

description: This thesis synthesises research of neural activation, ageing, and dementia, and builds a plausible theory for how music therapy can improve symptoms of dementia. This synthesis leads to predictions of how music therapy interventions target cognitive processes to improve dementia symptoms. Six participants with dementia completed eight-weeks of music therapy that involved working memory tasks and pre- and post-therapy neuroimaging. Working memory improved and neural activation changed in the dementia group. Music therapy is a viable short-term intervention that targets cognitive processes and could be a long-term intervention that incorporates positive modifiable lifestyle factors protecting the brain from dementia.
title: Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy
title: Insights from a Murine Aortic Transplantation Model
titleType: Subtitle
Creators: name: Oberhuber, Rupert
name: Riede, Gregor
name: Cardini, Benno
name: Bernhard, David
name: Messner, Barbara
name: Watschinger, Katrin
name: Steger, Christina
name: Brandacher, Gerald
name: Pratschke, Johann
name: Golderer, Georg
name: Werner, Ernst R.
name: Maglione, Manuel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Experimental models of disease
subject: Translational research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown to prevent IRI. Herein, we analysed whether tetrahydrobiopterin is also involved in TV development. Using a fully allogeneic mismatched (BALB/c to C57BL/6) murine aortic transplantation model grafts subjected to long cold ischemia time developed severe TV with intimal hyperplasia (α-smooth muscle actin positive cells in the neointima) and endothelial activation (increased P-selectin expression). Donor pretreatment with tetrahydrobiopterin significantly minimised these changes resulting in only marginal TV development. Severe TV observed in the non-treated group was associated with increased protein oxidation and increased occurrence of endothelial NOS monomers in the aortic grafts already during graft procurement. Tetrahydrobiopterin supplementation of the donor prevented all these early oxidative changes in the graft. Non-treated allogeneic grafts without cold ischemia time and syngeneic grafts did not develop any TV. We identified early protein oxidation and impaired endothelial NOS homodimer formation as plausible mechanistic explanation for the crucial role of IRI in triggering TV in transplanted aortic grafts. Therefore, targeting endothelial NOS in the donor represents a promising strategy to minimise TV.
Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals
Creators: name: Haskell, Crystal F.
name: Scholey, Andrew
name: Jackson, Philippa A.
name: Elliott, Jade
name: Defeyter, Margaret Anne
name: Greer, Joanna
name: Robertson, Bernadette C.
name: Buchanan, Tom
name: Tiplady, Brian
name: Kennedy, David O.
Publisher: name: Swinburne
Year: 2024

description: Adequate levels of vitamins and minerals are essential for optimal neural functioning. A high proportion of individuals, including children, suffer from deficiencies in one or more vitamins or minerals. This study investigated whether daily supplementation with vitamins/minerals could modulate cognitive performance and mood in healthy children. In this randomised, double-blind, placebo-controlled, parallel groups investigation, eighty-one healthy children aged from 8 to 14 years underwent laboratory assessments of their cognitive performance and mood pre-dose and at 1 and 3 h post-dose on the first and last days of 12 weeks' supplementation with a commercially available vitamins/mineral product (Pharmaton Kiddi™). Interim assessments were also completed at home after 4 and 8 weeks at 3 h post-dose. Each assessment comprised completion of a cognitive battery, delivered over the Internet, which included tasks assessing mood and the speed and accuracy of attention and aspects of memory (secondary, semantic and spatial working memory). The vitamin/mineral group performed more accurately on two attention tasks: 'Arrows' choice reaction time task at 4 and 8 weeks; 'Arrow Flankers' choice reaction time task at 4, 8 and 12 weeks. A single task outcome (Picture Recognition errors) evinced significant decrements at 12 weeks. Mood was not modulated in any interpretable manner. Whilst it is possible that the significant improvements following treatment were due to non-significant numerical differences in performance at baseline, these results would seem to suggest that vitamin/mineral supplementation has the potential to improve brain function in healthy children. This proposition requires further investigation.
Synergistic activity of the monolignol dillapiol and variation of its production in two plants, Anethum graveolens and Piper aduncum.
Creators: name: Belzile, Anne-Sophie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Entomology.

description: This study examined the plant derived monolignol dillapiol, a naturally occurring insecticide synergist. I initially compared dillapiol with the commercially-available piperonyl butoxide and showed similar synergistic activity of the two substances, combined with various natural insecticides, against the mosquito larvae (Aedes atropalpus). Subsequently, the activities of 19 synthetic dillapiol derivatives and analogues were assessed for synergism of the phototoxic activity of alpha-terthienyl towards A. atropalpus. While several promising new and patentable synthetic synergists were found, the naturally occurring lead molecule remained among the most active substances. The synergistic activity also was found to be predicted using the lipophilicity of the analogues, by Quantitative Structure-Activity Relationship analysis (QSAR). Given the practical potential of dillapiol, the second part of the thesis concentrated mainly on environmental parameters affecting dillapiol production in two plants, Indian dill, Anethum graveolens and the Central American wild pepper, Piper aduncum. It was found that a higher nutrient availability affected positively the production of dillapiol in dill in a greenhouse experiment but negatively in wild accessions of Piper aduncum. Simulation of herbivory using methyl jasmonate did not succeed in increasing the concentration of dillapiol in dill. Piper aduncum is a good commercial source of dillapiol since it produces it in very high concentrations (4% d.w.) and can be easily propagated by vegetative means.
Tissue-based methods to assess immune biomarkers within the tumor microenvironment on formalin fixed paraffin embedded clinical materials
Creators: name: Shenasa, Elahe
Publisher: name: University of British Columbia
Year: 2025

description: The tumor immune microenvironment plays a critical role in determining responses to immune-modulatory treatments, including certain types of cytotoxic chemotherapy and the new generation of immunotherapies. Given the severe and potentially long-term side effects these therapies can confer, there is an urgent need for effective immune biomarkers capable of selecting those patients who are most likely to benefit from such treatments. This thesis explores a range of methods, from standard hematoxylin and eosin staining to advanced high-plex digital spatial technologies, to study the immune microenvironment on human tumor tissue specimens and evaluate biomarkers with clinical relevance. Chapter 2 and 3 focus on assessing the prognostic and predictive values of immune biomarkers when applied to materials from randomized phase III clinical trials involving breast cancer patients. These chapters utilize and compare various techniques, including histology, immunohistochemistry, and multiplex digital spatial profiling, applied to clinical samples in tissue microarray and full-face section formats linked to treatment and long-term outcome data. Chapter 4 investigates methods with spatial capacity to detect tertiary lymphoid structures, a key biomarker associated with significant prognostic and predictive value for immunotherapy benefits, particularly in sarcomas. This chapter compares the effectiveness of tissue microarrays versus full-face sections in identifying tertiary lymphoid structures, highlighting the strengths and limitations of different approaches.