cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Implementation of Bus Rapid Transit in Copenhagen: A Mesoscopic Model Approach
Creators: name: Ingvardson, Jesper Bláfoss
name: Jensen, Jonas Kornerup
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Bus Rapid Transit (BRT) has shown to be an efficient and cost-effective mode of public transport, and has gained popularity in many cities around the world. To optimise the operations and infrastructure it is advantageous to deploy transport models. However, microscopic models are very inefficient for large scale corridors due to the vast amount of data and resources required. Hence, it is relevant to investigate how to model and evaluate BRT efficiently. In this paper the effects of implementing BRT in Copenhagen is discussed including how to evaluate and model bus operations. For this purpose, a mesoscopic simulation model is developed. In the model bus operations are modelled on a microscopic level whereas the interactions with other traffic are modelled macroscopically. This makes it possible to model high-frequency bus services such as BRT lines in more details without the time consumption of micro-simulation models. The developed model is capable of modelling bus operations in terms of travel time and reliability including important mode-specific issues such as bus bunching. The model is applied to a BRT project proposal with different combinations of BRT elements. The model results show that infrastructure upgrades (busways and enhanced stations) ensure a reduction to travel time whereas no improvements to reliability occur. Upgrades to technology and service planning (pre-paid fare collection, boarding and alighting from all doors, special BRT vehicles, ITS, and active bus control) ensure an increase in service reliability whereas only small reductions to travel time are observed. By combining all BRT elements it is possible to obtain synergies where the improved reliability due to planning and technology elements makes it possible to utilise the infrastructure optimally. Hence, it is possible to increase commercial speed from 14.8 to 19.9 km/h and service reliability in terms of headway time regularity from 46% to 84% aggregated on both directions for the morning peak period making the implementation of BRT feasible from a pure financial point of view.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
An argumentation-centred approach to translation quality assessment.
Creators: name: Williams, Malcolm.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Language, Linguistics.

description: Translation quality assessment (TQA) types may be divided into two main types: (1) models with a quantitative dimension, such as SEPT (1979), Sical (1986) and GTS (2000), and (2) non-quantitative, more textological models such as Nord (1991) and House (1997). Because it tends to focus on microtextual (lexical, syntactic) analysis, sampling and error counts, Type 1 suffers from major shortcomings. First, because of time constraints, it cannot assess, except on the basis of statistical probabilities, the acceptability of the content of the translation as discourse. Second, the microtextual analysis inevitably hinders any serious assessment of the content macrostructure of the translation. Third, the establishment of an acceptability threshold based on a specific number of errors is vulnerable to criticism both theoretically and in the marketplace. Type 2 cannot offer a cogent acceptability threshold either, precisely because it does not propose error weighting and quantification for individual texts. Another drawback of Type 2 is that it is applied almost exclusively to literary and advertising texts. What is needed is a model that combines the quantitative and textological dimensions, along the lines proposed by Bensoussan and Rosenhouse (1990) and Larose (1987, 1998), and targets instrumental (pragmatic) translations. The goal of this thesis is to develop an argumentation-centred model to meet this need. With Toulmin's argument macrostructure (1984) as a starting point, a set of argumentation parameters are developed: macrostructure, propositional functions (Widdowson 1978) and reasoning structure (Thomas 1986), conjunctives and inference indicators (Halliday and Hasan 1976; Roulet et al. 1985; and Thomas 1986), argument types (Corbett and Connors 1999), figures of speech, and narrative strategy (Ouellet 1992). These parameters provide a framework for assessing the degree to which translations preserve the argumentation, coherence and cohesion of the message of the source text, for determining critical passages for TQA, and for proposing a new breakdown of errors based on three levels of seriousness. A weighting grid is then added to the model to enable evaluators to take account of conventional parameters such as target-language errors. Finally, a new set of quality standards is proposed for instrumental texts produced by professionals and students alike.
Efficient associative data structures for bitemporal databases.
Creators: name: Eid, Ashraf.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Computer Science.

description: Most applications require storing multiple versions of data and involve a lot of temporal semantics in their schema. This requires maintenance and querying of temporal relations. A Bitemporal DBMS will simplify the development and maintenance of such applications by moving temporal support from the application into the DBMS engine. The success of such Bitemporal DBMSs relies mainly on the availability of high performance indices that handle update and search operations efficiently. A successful associative data structure (index) is the one that can efficiently partition the space of the attributes that are used within the keys. Temporal attributes have unique characteristics and should support now-relative intervals. These intervals grow as time grows and thus we need an index that can handle attributes with variable values. The proposed bitemporal index partitions the bitemporal space into four subspaces according to the end value of the temporal intervals. This results in separating those keys that have variable intervals from those that have fixed interval(s). In this thesis we have used on-the-shelf index that successfully indexes spatial attributes. But instead of representing the two temporal dimensions as a rectangle, we have represented them as 4 dimensional points. This results in better partitioning of each subtree space and in better search performance.
Tourismus und Umwelt
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: subject: UFORDAT
subject: Tourismus
subject: Forschungsprojekte
subject: Umweltforschungsdatenbank
subject: Umweltfreundlicher Tourismus
subject: Nachhaltigkeit | Strategien | Internationales

description: In dem aktuellen Themenauszug der Umweltforschungsdatenbank sind Forschungsprojekte zum Thema Tourismus und Umwelt zusammengestellt, die seit 2005 neu begonnen wurden. Ergänzt wird die Dokumentation durch eine Auswertung zur Forschungsstruktur: Wie entwickelt sich die Forschung? Wer forscht? Wer finanziert die Forschung?
Effekter ved afsluttede puljeprojekter
Creators: name: Amelung, Sine
name: Hansen, Henrik Severin
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Trafikstyrelsens to buspuljer, Fremkommelighedspuljen og Passagerpuljen, har siden 2009 igangsat mere end 200 projekter, og indtil nu er over 90 projekter afsluttede. Projekterne har bl.a. skabt passagervækst, mere tilfredse kunder samt mere innovation, samarbejde og udvikling i den kollektive trafik.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Central monoaminergic pathways in appetite regulation
Creators: name: Aklan, Iltan
Publisher: name: University of Iowa
Year: 2023
Subjects: AgRP neuron
appetite
Catecholamine
Serotonin
public abstract

description: Obesity is a major health and economic concern worldwide. It decreases life quality and increases mortality rate. The high risk of mortality is linked to life-threatening comorbidities such as cardiovascular disease and oncologic diseases. It is estimated that almost 1 in 2 people will be obese by 2030. While there are new promising pharmaceutical treatments that have recently hit the market, these treatments have varying levels of efficacy in patients. Thus, it is crucial to understand the underlying causes of obesity. Sustained overconsumption of high calorie food leads to positive energy balance which promotes obesity. Most of the current therapeutic agents used to combat obesity work by reducing appetite, which highlights the importance of understanding how the brain controls feeding. In the central nervous system (CNS), there are many molecules and cell types that regulate food intake. This thesis is mainly focused on the role of monoaminergic neural pathways in appetite regulation. The first part of this dissertation will focus on serotonin, a well-known anorectic molecule produced by the dorsal raphe nucleus (DRN). Through this work, we demonstrate that DRNSERTforebrain circuits regulate satiety. Second, we examine novel appetite regulation in a unique brain region called the nucleus solitary tract (NTS). The NTS is a crucial hub transferring gustatory and endocrine signals from the periphery to the brain. Our work reveals that NTS catecholaminergic (CA) neurons project to the paraventricular hypothalamic nucleus (PVN) to regulate appetite control. Anterior NTSCAPVN increases appetite, while posterior NTSCAPVN causes satiety. Also, stimulation of posterior NTSCAPVN pathway shows anxiety-like behavior. The last section of this dissertation will examine the central control of feeding time. To accomplish this, we focus primarily on agouti-related peptide (AgRP) neurons which are known as “hunger neurons.” We reveal that rhythmic AgRP neuronal activation partially mimics food entrainment. Also, we examined the effect of opioidergic signaling onto AgRP neurons and found that activation of mu opioid receptor directly decreases AgRP neuronal activity which may lead to satiety.
description: Overall, my thesis work reveals unique neural pathways that regulate appetite which may be helpful for future drug developments to combat obesity and eating disorders.
A compact concentration of large grains in the HD 142527 protoplanetary dust trap
Creators: name: Casassus, Simon
name: Wright, Chris M.
name: Marino, Sebastian
name: Maddison, Sarah
name: Wootten, Al
name: Roman, Pablo
name: Pérez, Sebastian
name: Pinilla, Paola
name: Wyatt, Mark
name: Moral, Victor
name: Ménard, Francois
name: Christiaens, Valentin
name: Cieza, Lucas
name: Plas, Gerrit van der
Publisher: name: Swinburne
Year: 2024

description: A pathway to the formation of planetesimals, and eventually giant planets, may occur in concentrations of dust grains trapped in pressure maxima. Dramatic crescent-shaped dust concentrations have been seen in recent radio images at submillimeter wavelengths. These disk asymmetries could represent the initial phases of planet formation in the dust trap scenario, provided that grain sizes are spatially segregated. A testable prediction of azimuthal dust trapping is that progressively larger grains should be more sharply confined and should follow a distribution that is markedly different from the gas. However, gas tracers such as 12CO and the infrared emission from small grains are both very optically thick where the submillimeter continuum originates, so previous observations have been unable to test the trapping predictions or to identify compact concentrations of larger grains required for planet formation by core accretion. Here we report multifrequency observations of HD 142527, from 34 to 700 GHz, that reveal a compact concentration of grains approaching centimeter sizes, with a few Earth masses, embedded in a large-scale crescent of smaller, submillimeter-sized particles. The emission peaks at wavelengths shorter than ∼1 mm are optically thick and trace the temperature structure resulting from shadows cast by the inner regions. Given this temperature structure, we infer that the largest dust grains are concentrated in the 34 GHz clump. We conclude that dust trapping is efficient enough for grains observable at centimeter wavelengths to lead to compact concentrations.
Udbygning af den kollektive trafik i København
Creators: name: Bønløkke, Peter
name: Elle, Søren
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Hovedstaden står over for store trafikale udfordringer. Udbygningen af metrosystemet og anlæg af nye letbaner er Københavns bedste bud på en attraktiv storby med høj mobilitet og god tilgængelighed. Derfor peges der nu efter flere års screenings og analysearbejde på at gå videre med to konkrete projekter, nemlig metro til Ny Ellebjerg via Sydhavn og analyse af letbane på Frederikssundsvej.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
The Characterization of a Human Disease-Associated Mutation Nkx2.5 R142C Using In vitro and In vivo Models
Creators: name: Zakariyah, Abeer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Transcription factors
Congenital heart defects
mouse embryonic stem cells
cardiac muscle differentiation

description: Nkx2.5 is a cardiac transcription factor that plays a critical role in heart development. In humans, heterozygous mutations in the NKX2.5 gene result in congenital heart defects (CHDs), but the molecular mechanisms by which these mutations cause the defects are still unknown. NKX2.5 R142C is a mutation that is found to be associated with atrial septal defect and atrioventricular block in 13 patients from one family. The R142C mutation is located within both the DNA-binding domain and the nuclear localization sequence of NKX2.5 protein. The pathogenesis of CHDs in humans with R142C point mutation is not well understood. Also, a previous study in our laboratory has identified Mypt1/PP1 as a novel interacting partner of Nkx2.5 in stem cells during cardiomyogenesis. Nkx2.5 has a PP1-binding consensus sequence RVxF located in the N-terminus of the homeodomain. Notably, the PP1-binding sequence, RVxF, is mutated from arginine to cysteine in patients with the R142C heterozygous mutation. However, the ability of the R142C mutation to bind to the Mypt1/PP1 complex has not been investigated yet. The following thesis addresses the functional deficit associated with R142C by utilizing a combination of in vitro, and in vivo models. It also addresses the interaction of Mypt1/PP1 with the R142C mutation. We have generated a heterozygous mouse embryonic stem cell (mESC) line, harboring the murine homologue (R141C) of the human mutation R142C in Nkx2.5 gene. We show reduced cardiomyogenesis and impaired subcellular localization of Nkx2.5 protein in Nkx2.5R141C/+ mESCs. Gene expression profiling of Nkx2.5R141C/+ mESCs revealed a global misregulation of genes important for heart development and identified putative direct target genes of Nkx2.5 that are affected by the R141C heterozygous mutation. We also generated a mouse model harboring the human mutation R142C. We show that the Nkx2.5R141C/R141C homozygous embryos are developmentally arrested around E10.5 with delayed heart morphogenesis. Moreover, Nkx2.5R141C/+ newborn mice are grossly normal but show variable cardiac defects and downregulation of ion channel genes that later cause AV block in adult mice. Finally, we show that the R141C mutant binds to the Mypt1/PP1 complex but is not inhibited or translocated to the perinuclear region in the presence of Mypt1/PP1 as the WT Nkx2.5 is.
ZFIRE: GALAXY CLUSTER KINEMATICS, Hα STAR FORMATION RATES, and GAS PHASE METALLICITIES of XMM-LSS J02182-05102 at zcl=1.6233
Creators: name: Tran, Kim Vy H
name: Nanayakkara, Themiya
name: Yuan, Tiantian
name: Kacprzak, Glenn
name: Glazebrook, Karl
name: Kewley, Lisa J.
name: Momcheva, Ivelina
name: Papovich, Casey J.
name: Quadri, Ryan
name: Rudnick, Greg
name: Saintonge, Amélie
name: Spitler, Lee R.
name: Straatman, Caroline
name: Tomczak, Adam
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We spectroscopically survey the galaxy cluster XMM-LSS J02182-05102 (hereafter IRC 0218) using LRIS (optical) and MOSFIRE (near-infrared) on Keck I as part of the ZFIRE survey. IRC 0218 has a narrow redshift range of 1.612 < zspec < 1.635 defined by 33 members of which 20 are at Rproj < 1Mpc. The cluster redshift and velocity dispersion are zcl =  1.6233 0.0003 and scl =  254 50 km s−1 . We reach NIR line sensitivities of ∼0.3 × 10−17 erg s−1 cm−2 that, combined with multi-wavelength photometry, provide extinction-corrected Hα star formation rates (SFR), gas phase metallicities from [N II]/Hα, and stellar masses. We measure an integrated Hα SFR of ∼325 M yr-1  (26 members; Rproj < 2 Mpc) and show that the elevated star formation in the cluster core (Rproj < 0.25 Mpc) is driven by the concentration of star-forming members, but the average SFR per Hα-detected galaxy is half that of members at Rproj ∼ 1 Mpc. However, we do not detect any environmental imprint when comparing attenuation and gas phase metallicities: the cluster galaxies show similar trends with M as to the field, e.g., more massive galaxies have larger stellar attenuation. IRC 0218’s gas phase metallicity–M relation (MZR) is offset to lower metallicities relative to z ~ 0 and has a slope of 0.13 ± 0.10. Comparing the MZR in IRC 0218 to the COSMOS cluster at z = 2.1 shows no evolution (Dt ~ 1 Gyr): the MZR for both galaxy clusters are remarkably consistent with each other and virtually identical to several field surveys at z ~ 2.
title: Ausweitung des Emissionshandels auf Kleinemittenten im Gebäude- und Verkehrssektor
title: Ausweitung des Emissionshandels auf Kleinemittenten im Gebäude- und Verkehrssektor
titleType: AlternativeTitle
Creators: name: Hermann, Hauke
name: Cludius, Johanna
name: Förster, Hannah
Publisher: name: My University
Year: 2014
Subjects: subject: Klimapolitik
subject: Emissionshandel
subject: Verkehr
subject: Gebäude
subject: Energiesteuer
subject: Emissionshandel im Verkehr
subject: Kleinemittent
subject: Klima | Energie
subject: Climate | Energy
subject: Verkehr
subject: Transport

description: Im Rahmen dieses Projektes wurde untersucht, inwieweit bisher nicht erfasste Treibhaus-gasemissionen in Deutschland mittels eines upstream-ausgerichteten Emissionshandelssystems (Upstream-Emissionshandelssystem) in den EU ETS einbezogen werden könnten. Verschiedene Möglichkeiten zur Ausgestaltung wurden ökologisch, ökonomisch und juristisch bewertet. Ein wichtiger Untersuchungsgegenstand war dabei auch das Zusammenspiel mit existierenden deutschen und europäischen klima- und energiepolitischen Instrumenten. Die Studie kommt zu dem Ergebnis, dass die Einführung eines Upstream- Emissionshandelssystems juristisch möglich ist und administrativ mit überschaubarem Aufwand umsetzbar wäre.
Quelle: Forschungsbericht
description: Within the scope of this project the extent to which the GHG emissions in Germany not covered up to now could be included in the EU ETS by means of an upstream emissions trading scheme (upstream ETS) was analysed. Different options have been assessed from an envi-ronmental, economic and legal perspective. The specific analysis conducted in this report arrives at the conclusion that the introduction of an upstream ETS cannot be recommended at present since it can hardly solve the problems of the existing EU ETS - e.g. excessively high surpluses - on its own. Currently it is more important to repair the existing scheme than to expand the scope of emissions trading. Additionally, in the current mix of climate policy instruments, the incorporation of small emitters from the transport or households sectors in the EU ETS would not provide any significant added value. But the implementa-tion of an upstream ETS remains an attractive option in the long term, particularly with a view to the increasing interaction between sectors. Quelle: Forschungsbericht
description: Im Rahmen dieses Projektes wurde untersucht, inwieweit bisher nicht erfasste Treibhaus-gasemissionen in Deutschland mittels eines upstream-ausgerichteten Emissionshandelssystems (Upstream-Emissionshandelssystem) in den EU ETS einbezogen werden könnten. Verschiedene Möglichkeiten zur Ausgestaltung wurden ökologisch, ökonomisch und juristisch bewertet. Ein wichtiger Untersuchungsgegenstand war dabei auch das Zusammenspiel mit existierenden deutschen und europäischen klima- und energiepolitischen Instrumenten. Die Studie kommt zu dem Ergebnis, dass die Einführung eines Upstream- Emissionshandelssystems juristisch möglich ist und administrativ mit überschaubarem Aufwand umsetzbar wäre.
Telomere Length Is Not Related to Established Cardiovascular Risk Factors but Does Correlate with Red and White Blood Cell Counts in a German Blood Donor Population
Creators: name: Neuner, Bruno
name: Lenfers, Anna
name: Kelsch, Reinhard
name: Jäger, Kathrin
name: Brüggmann, Nina
name: Harst, Pim Van Der
name: Walter, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Telomere length (TL) is considered a marker of biological aging and has been associated with the presence of various coronary risk factors in patients. Much less is known about the relationships between TL and classic coronary risk factors in other populations. We measured TL in peripheral blood leukocytes of 343 middle-aged blood donors (mean age 40.2 ± 12.4 years; 201 men, 142 women) using quantitative polymerase chain reaction. Median TL was 0.86 (range: 0.48–1.85) relative TL units. In linear regression analyses with natural log-transformed T to S ratio as the dependent variable, there was a significant association with age (per year: beta = -0.007, p<0.001) and sex (males vs. females: beta = 0.075, p = 0.007) with longer telomeres in men. After adjusting for these two variables, we observed no association of TL with classic coronary risk factors including cholesterol (p = 0.36), triglyceride (p = 0.09), HDL-cholesterol (p = 0.26), LDL-cholesterol (p = 0.36), smoking (p = 0.97), and personal (p = 0.46) or family history (p = 0.63) of cardiovascular disease. However, we did find a significant positive association with white (p = 0.011) and red blood cell count (p = 0.031), hemoglobin (p = 0.014) and hematocrit (p = 0.013); we also found a borderline positive association with thrombocytes (p = 0.074). Positive associations remained significant for hemoglobin (p = 0.017), hematocrit (p = 0.023), and leukocytes (p = 0.009) in a subgroup with no reported vascular disease; associations were of borderline significance for erythrocytes (p = 0.053) and thrombocytes (p = 0.088) in this subgroup. The data do not support the concept that classic coronary risk factors contribute to telomere attrition in a blood donor population. However, telomere attrition may be a marker for reduced proliferation reserve in hematopoietic progenitor cells.
Uncovering the latent structure of visuospatial ability and predicting visuospatial dysfunction from lesion location
Creators: name: Skye, Jax Dimitri
Publisher: name: University of Iowa
Year: 2023
Subjects: brain lesion
clinical predictive model
lesion network mapping
lesion-symptom mapping
visuospatial ability
public abstract
Stroke

description: Visuospatial ability is the ability to perceive, understand, and utilize visual sensory data to construct a spatial map of one’s environment. Visuospatial dysfunction commonly occurs following brain lesions and often improves in the first few months post-injury; however, some patients continue to have chronic visuospatial dysfunction which can have a devastating impact on recovery trajectory, the ability to live independently, and quality of life. Prognoses for these patients are often made based on clinical intuition, but an evidence-based approach for predicting long-term visuospatial dysfunction in the acute epoch of recovery remains elusive. This study sought to identify the latent structure of visuospatial ability, investigate brain regions and networks involved in visuospatial ability independent of the tests used to measure it, and develop a model to predict long-term visuospatial dysfunction in two out-of-sample cohorts. Exploratory factor analysis was used to identify potential latent variables representing domain-general visuospatial ability across twelve neuropsychological tests in patients from the Iowa Neurological Patient Registry (n = 480). One latent variable, “domain-general visuospatial ability”, described variance in this sample best. Brain regions and networks associated with domain-general visuospatial ability were identified using multivariate lesion-symptom mapping and lesion network mapping. Finally, models were compared to determine the best predictors of long-term visuospatial dysfunction in the Benton Neuropsychology Clinic cohort (n = 80) and the Washington University cohort (n = 104). Domain-general visuospatial ability was associated with right hemisphere damage to the putamen and bilateral damage to posterior white matter tracts constituting the dorsal visual stream in the lesion-symptom map. After controlling for general cognitive ability, only right white matter damage was implicated. Damage to regions in the dorsal attention network and visual network along with posterior inter- and intra-hemispheric white matter was also associated with visuospatial dysfunction. A model including functional lesion network mapping, structural lesion network mapping, and lesion volume best predicted outcomes in both validation cohorts. This study provides novel evidence for the right putamen’s importance in visuospatial ability and confirms the previously identified involvement of the dorsal visual stream, dorsal attention network, and visual network in visuospatial ability. Furthermore, my predictive model is one step towards the broader goal of predicting long-term outcomes of brain damage in the acute epoch.
Correction to: FLAGS, frequently mutated genes in public exomes
Creators: name: Shyr, Casper
name: Tarailo-Graovac, Maja
name: Gottlieb, Michael
name: Lee, Jessica J.
name: Van Karnebeek, Clara
name: Wasserman, Wyeth W.
Publisher: name: BioMed Central
Year: 2017

description: Correction Unfortunately, the original article [1] contained an error. The additional files were included incorrectly. The correct additional files 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 and 14 are published in this correction.
Intestinal microbiota and the innate immune system – a crosstalk in Crohn’s disease pathogenesis
Creators: name: Haag, Lea-Maxie
name: Siegmund, Britta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Crohn’s disease
subject: innate immune system
subject: inflammation
subject: microbiota
subject: dysbiosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Crohn’s disease (CD) is a chronic, relapsing inflammatory disorder that can occur anywhere along the gastrointestinal tract. The precise etiology of CD is still unclear but it is widely accepted that a complex series of interactions between susceptibility genes, the immune system and environmental factors are implicated in the onset and perpetuation of the disease. Increasing evidence from experimental and clinical studies implies the intestinal microbiota in disease pathogenesis, thereby supporting the hypothesis that chronic intestinal inflammation arises from an abnormal immune response against the microorganisms of the intestinal flora in genetically susceptible individuals. Given that CD patients display changes in their gut microbiota composition, collectively termed “dysbiosis,” the question raises whether the altered microbiota composition is a cause of disease or rather a consequence of the inflammatory state of the intestinal environment. This review will focus on the crosstalk between the gut microbiota and the innate immune system during intestinal inflammation, thereby unraveling the role of the microbiota in CD pathogenesis.
title: Checklisten für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie
title: Zellulose- und Papierindustrie: Checkliste Nr. ZT. 5: Ablauge
titleType: AlternativeTitle
Creators: name: Winkelmann-Oei, Gerhard
Publisher: name: My University
Year: 2016
Subjects: subject: Papierindustrie
subject: Zellstoffindustrie
subject: Gewässerschutz
subject: Wasserverunreinigung
subject: Risikomanagement
subject: Leitfaden
subject: Zelluloseindustrie
subject: Zellstoffproduktion
subject: Wasserverschmutzung
subject: Wasserschadstoffe
subject: Checkliste
subject: Chemikalien
subject: Chemicals

description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren. Quelle: Bericht
description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren.
Small scatter and nearly isothermal mass profiles to four half-light radii from two-dimensional stellar dynamics of early-type galaxies
Creators: name: Cappellari, Michele
name: Romanowsky, Aaron J.
name: Brodie, Jean
name: Forbes, Duncan
name: Strader, Jay
name: Foster, Caroline
name: Kartha, Sreeja S.
name: Pastorello, Nicola
name: Pota, Vincenzo
name: Spitler, Lee R.
name: Usher, Christopher
name: Arnold, Jacob A.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We study the total mass-density profile for a sample of 14 fast-rotator early-type galaxies (stellar masses 10.2 ≲ logM/M* ⊙ ≲ 11.7). We combine observations from the SLUGGS and Atlas3D surveys to map out the stellar kinematics in two-dimensions, out to a median radius for the sample of four half-light radii Re (or 10 kpc), and a maximum radius of 2.0-6.2 Re (or 4-21 kpc). We use axisymmetric dynamical models based on the Jeans equations, which allow for a spatially varying anisotropy, and employ quite general profiles for the dark halos, and in particular do not place any restriction on the profile slope. This is made possible by the availability of spatially extended two-dimensional kinematics. We find that our relatively simple models provide a remarkably good description of the observed kinematics. The resulting total density profiles are well described by a nearly-isothermal power law ρtot(r)∝r−γ from Re/10 to at least 4Re, the largest average deviation being 11%. The average logarithmic slope is ⟨γ⟩=2.19±0.03 with observed rms scatter of just σγ=0.11. This scatter out to large radii, where dark matter dominates, is as small as previously reported by lensing studies around r≈Re/2, where the stars dominate. Our bulge-halo conspiracy places much tighter constraints on galaxy formation models. It illustrates the power of two-dimensional stellar kinematics observations at large radii. It would now be important to test the generality of our results for different galaxy types and larger samples.
Central Office Coherence in Hamilton County Schools
Creators: name: Rice, John
Publisher: name: University of Iowa
Year: 2023
Subjects: central office
coherence
district office
district leadership
theory of action
public abstract

description: Background: Central offices play a critical but often overlooked role in student achievement in school districts. Prior research has suggested that central offices that prioritize coherence in the beliefs, communication, and structures of a focused theory of action can achieve improved results in student achievement.
description: Setting: Hamilton County Schools, a public school district in the Chattanooga, Tennessee metro area serving 45,000 students across 79 schools in the 2022-2023 school year.
description: Participants: Ten senior leaders in the school district’s central office.
description: Research Design: Qualitative case study based on interviews of senior leaders, district communications, and central office structures
description: Data Collection and Analysis: Summative content analysis and document analysis were used to examine interviews and district documents to assess the level of coherence in three areas: senior leaders’ beliefs, communication, and structures around a focused theory of action.
description: Findings: For the 2022-2023 school year, the Hamilton County Schools central office has ample evidence of coherence in beliefs, communication, and structures. However, several areas of incoherence emerged from the analysis that are barriers to more widespread implementation.
description: Conclusions: This case study demonstrates that central offices can and should create organizational coherence to best serve their students.
title: Sociodemographic, home environment and parental influences on total and device-specific screen viewing in children aged 2 years and below
title: an observational study
titleType: Subtitle
Creators: name: Goh, Si Ning
name: Teh, Long Hua
name: Tay, Wei Rong
name: Anantharaman, Saradha
name: Dam, Rob M. Van
name: Tan, Chuen Seng
name: Chua, Hwee Ling
name: Wong, Pey Gein
name: Müller-Riemenschneider, Falk
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective This study aimed to investigate total and device-specific screen viewing (SV) and its determinants in children aged 2 years and below. Design Cross-sectional study conducted in February 2014. Setting Well-child clinics in Singapore national polyclinics. Participants Parents of children (Singapore citizens or permanent residents) aged 2 years and below were enrolled during routine clinic visits. Out of 794 eligible parent–child dyads, 725 (91.3%) provided informed consent and were included in the analysis. Main outcome measures Device-specific information on SV and determinants was ascertained using interviewer-administered survey questionnaires. The prevalence and duration of aggregate and device-specific SV were reported. Associations with potential determinants were investigated using multiple logistic regression analysis. A p value less than 0.05 was considered statistically significant. Results The prevalence of daily SV and SV ≥2 h/day constituted 53.5% and 16.3%, respectively. The majority of children aged 18–24 months (88.2%) engaged in daily SV. TVs and mobile devices were the most commonly used screen devices, followed by computers and video consoles. In multivariable analysis, younger child age, Chinese ethnicity and setting rules on time of SV were strongly and consistently associated with lower levels of any SV and SV ≥2 h/day. Parental knowledge of SV recommendations and less parental SV were additionally associated with lower levels of SV ≥2 h/day. The number of screen devices was not associated with children's SV. Conclusions In contrast to recommendations, SV prevalence in children aged less than 2 years is high and appears to increase steadily across age groups. TVs and mobile devices are most frequently used. Improving parental knowledge of SV recommendations, reducing parental SV and especially the implementation of strict rules on SV time could be successful strategies to reduce SV in young children.
Perceived environmental control over interuniversity athletics in Canada: A resource dependence perspective.
Creators: name: Armstrong, Alison J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Education, Finance.

description: The purpose of this study was to determine whether those environmental elements which provide financial resources to the organization were perceived by the athletics directors to have control over the interuniversity athletics program. A theoretical framework, which incorporated the Emerson (1962) power-dependence theory of social exchange relations, and the concepts of resource dependence and power, was developed to examine the following hypothesis: The interuniversity athletics organization is perceived to be controlled by the elements (individuals, groups, organizations) in its environment in relation to its relative resource dependence on those elements. Another purpose of the study was to examine Emerson's power-dependence theory in the context of interuniversity athletics. Athletics directors from 34 (75.5%) of the 45 interuniversity athletics organizations in Canada completed the Survey of Canadian Interuniversity Athletics Programs and an accompanying interview. The survey elicited information about the organization's resource dependence on various sources in its environment, in terms of relative funding, as well as perceptions of the control of 15 environmental elements over seven basic activities of the organization, and overall. The interview was useful for further investigating the dynamics of perceived control. The organization, itself, was included as one of the elements. Univariate ANOVAs with repeated measures on the environmental elements were used to further describe organizational autonomy and perceived environmental control, and t-tests were employed to compare the organization's relative resource dependencies. The study concluded that perceived environmental control was varyingly associated with the organization's resource dependence on its environment. The findings imply that perceived control may be based in other dependencies, which warrant examination. Although there was limited support for the power-dependence theory in the context of interuniversity athletics and financial dependence, it may be more appliable when other relevant dependencies are considered. (Abstract shortened by UMI.)
Green public procurement
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2018
Subjects: subject: Umweltfreundliche Beschaffung
subject: Produktkennzeichnung
subject: Öffentliche Beschaffung
subject: green procurement
subject: environmental friendly procurement
subject: Blue Angel
subject: public procurement
subject: sustainable product
subject: Wirtschaft | Konsum

description: Each year, German contracting authorities purchase some âą 300 billion worth of products ranging from pencils to city buses. This massive purchasing power can potentially be used to reduce environmental pollution, improve environmental product and service portfolios, and promote more targeted market launches of innovative eco-friendly products. When it comes to public procurement, itâ€Ìs often a relatively simple matter to make a conscious decision to procure more eco-friendly products. The aim of this flyer is to explain how this can be done. Quelle: https://www.umweltbundesamt.de
description: Each year, German contracting authorities purchase some €300 billion worth of products ranging from pencils to city buses. This massive purchasing power can potentially be used to reduce environmental pollution, improve environmental product and service portfolios, and promote more targeted market launches of innovative eco-friendly products. When it comes to public procurement, it’s often a relatively simple matter to make a conscious decision to procure more eco-friendly products. The aim of this flyer is to explain how this can be done.Note: The leaflet is optimized for A3 printing.
Warren D. Chandler to T. Bayles Minuse, August 1, 1955
Creators: name: Chandler, Warren D.
Publisher: name: Unknown
Year: 1955
Subjects: Stony Brook
Publishers
Newspapers
Advertising
Advertisements
Correspondence

description: This letter is written by Warren D. Chandler of Publishers' Association of New York City to T. Bayles Minuse on August 1, 1955, in regards to a request for a questionnaire.
ASKAP HI imaging of the galaxy group IC 1459
Creators: name: Serra, P.
name: Koribalski, B.
name: Kilborn, Virginia
name: Allison, J. R.
name: Amy, S. W.
name: Ball, L.
name: Bannister, K.
name: Bell, M. E.
name: Bock, D. C.-J.
name: Bolton, R.
name: Bowen, M.
name: Boyle, B.
name: Broadhurst, S.
name: Brodrick, D.
name: Brothers, M.
name: Bunton, J. D.
name: Chapman, J.
name: Cheng, W.
name: Chippendale, A. P.
name: Chung, Y.
name: Cooray, F.
name: Cornwell, T.
name: DeBoer, D.
name: Diamond, P.
name: Forsyth, R.
name: Gough, R.
name: Gupta, N.
name: Hampson, G. A.
name: Harvey-Smith, L.
name: Hay, S.
name: Hayman, D. B.
name: Heywood, I.
name: Hotan, A. W.
name: Hoyle, S.
name: Humphreys, B.
name: Indermuehle, B.
name: Jacka, C.
name: Jackson, C. A.
name: Jackson, S.
name: Jeganathan, K.
name: Johnston, S.
name: Joseph, J.
name: Kamphuis, P.
name: Leach, M.
name: Lenc, E.
name: Lensson, E.
name: Mackay, S.
name: Marquarding, M.
name: Marvil, J.
name: McClure-Griffiths, N.
name: McConnell, D.
name: Meyer, M.
name: Mirtschin, P.
name: Neuhold, S.
name: Ng, A.
name: Norris, R. P.
name: O'Sullivan, J.
name: Pathikulangara, J.
name: Pearce, S.
name: Phillips, C.
name: Popping, A.
name: Qiao, R. Y.
name: Reynolds, J. E.
name: Roberts, P.
name: Sault, R. J.
name: Schinckel, A. E. T.
name: Shaw, R.
name: Shimwell, T. W.
name: Staveley-Smith, L.
name: Storey, M.
name: Sweetnam, A. W.
name: Troup, E.
name: Tzioumis, A.
name: Voronkov, M. A.
name: Westmeier, T.
name: Whiting, M.
name: Wilson, C.
name: Wong, O. I.
name: Wu, X.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We present H i imaging of the galaxy group IC 1459 carried out with six antennas of the Australian Square Kilometre Array Pathfinder equipped with phased-array feeds. We detect and resolve H i in 11 galaxies down to a column density of ∼1020 cm−2 inside a ∼6 deg2 field and with a resolution of ∼1 arcmin on the sky and ∼8  km s−1 in velocity. We present H i images, velocity fields and integrated spectra of all detections, and highlight the discovery of three H i clouds – two in the proximity of the galaxy IC 5270 and one close to NGC 7418. Each cloud has an H i mass of ∼109 M⊙ and accounts for ∼15 per cent of the H i associated with its host galaxy. Available images at ultraviolet, optical and infrared wavelengths do not reveal any clear stellar counterpart of any of the clouds, suggesting that they are not gas-rich dwarf neighbours of IC 5270 and NGC 7418. Using Parkes data, we find evidence of additional extended, low-column-density H i emission around IC 5270, indicating that the clouds are the tip of the iceberg of a larger system of gas surrounding this galaxy. This result adds to the body of evidence on the presence of intragroup gas within the IC 1459 group. Altogether, the H i found outside galaxies in this group amounts to several times 109 M⊙, at least 10 per cent of the H i contained inside galaxies. This suggests a substantial flow of gas in and out of galaxies during the several billion years of the group's evolution.
Development of sensory processing in rat primary motor cortex
Creators: name: Glanz, Ryan
Publisher: name: University of Iowa
Year: 2022
Subjects: Development
Motor cortex
Myoclonic twitching
Neural information
Rat
REM sleep
public abstract

description: Primary motor cortex (M1) undergoes protracted development in mammals, functioning initially as a sensory structure. Throughout the first postnatal week in rats, M1 is strongly activated by self-generated forelimb movements—especially by the twitches that occur during active (or REM) sleep. In this dissertation, we quantify the kinematic features of forelimb movements to reveal receptive-field properties of individual units within the forelimb region of M1. At postnatal day (P) 8, nearly all units are strongly modulated by movement amplitude, especially during active sleep. By P12, only a minority of units continue to exhibit amplitude-tuning, regardless of behavioral state. At both ages, movement direction also modulates M1 activity, though to a lesser extent.
description: We also demonstrate that M1 activity is discontinuous at P8: Periods of silence are punctuated by bursts of activity arising from limb movements. At P12, cortical activity dramatically shifts to become continuous (near-constant). Because continuous activity may “hide” important kinematic information, we use a computational approach to reveal this information by reconstructing twitches and wake movements from M1 activity. Surprisingly, information related to wake movements, but not to twitches, was revealed by neural decoding after the transition to continuous activity. Finally, we perform a series of computational experiments to demonstrate that M1 activity is informationally denser and more individuated to a particular pup at P12 than at P8.
description: Altogether, these findings reveal a transition toward a more complex and informationally rich representation of movement long before M1 develops its motor functionality.
From the faculty perspective: Factors that influence the development of organizational culture within a new school of education
Creators: name: Addison, Emily
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Education, Sociology of.
subject: Education, Teacher Training.
subject: Education, Higher.

description: This study examines the process of organizational culture development within a new school of education, focusing on the various factors that influence culture as perceived by faculty. The research is situated within a mid-sized university in Canada. From the data analysis emerged the following factors that participants saw as influencing culture: leadership; other members of the organization; programmatic influences; the mission statement, goals, and conceptual framework; organization structure and size; physical space and location; resource and financial considerations; the fact that everything was new; workload and time constraints; the wider university; other external influences; and the field of study. The significance of the study is threefold. One is that it contributes to a sparse body of literature regarding the development of culture in educational organizations. Secondly, it informs organizations of considerations to be made in regards to the development of culture, and finally, the study informs the research locale.