cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Soil microbial attributes and function across multiple scales in Neotropical Savanna
Creators: name: Siewerding Meirelles, Gabriela
Publisher: name: Lancaster University
Year: 2020
Subjects: Cerrado biome
Gallery forest
Vereda
Cerrado sensu stricto
anthopogenic disturbance
topography
flooding
soil properties
soil resistance and resilience

description: Savannas are the most sensitive ecosystems to future changes in land use and climate. Therefore, understanding of the factors underpinning savanna ecosystem function is urgently required for ecologically-relevant conservation and management. This thesis aims to address this knowledge gap, investigating how local conditions and landscape features influence soil microbial attributes, and the resistance and resilience of soil functioning within the three distinct vegetation types of the Brazillian Cerrado biome: Gallery forest, Veredas and Cerrado sensu stricto. Firstly, I evaluated how local vegetation characteristics and soil physico-chemical properties interact and influence soil microbial attributes (Chapter 2). Secondly, I investigated how landscape-scale anthropogenic disturbance and topography affect soil microbial community structure and enzyme activity (Chapter 3). I also assessed how soil CO2 emissions are related to microbial attributes and topography, and the resistance and resilience of soil functioning (respiration) of the vegetation types in response to drought and drying-rewetting (Chapter 4). Lastly, I conducted an experiment to investigate the mechanisms underpinning C mineralisation in rewetted soils from the different Cerrado vegetation types (Chapter 5). At the local scale, I found different patterns in above- and below-ground interactions within the three vegetation types. Soil physico-chemical properties strongly affected soil microbial attributes in Gallery forests and Veredas, whereas vegetation characteristics were the main determinant in Cerrado sensu stricto. At the landscape scale, I found topography to be the major predictor of microbial attributes in all vegetation types, and that anthropogenic disturbance influences soil microbial communities both positively and negatively. Veredas soils were the most resistant to drought, while Gallery forests soils were the most resilient in their reponse to rewetting after drought. I also discovered that soil organic matter quality combined with nutrient availability influenced different mechanisms underpinning soil C stock and release to the atmosphere across the different Cerrado types. Based on these findings, I discuss the importance of flooding regimes in the wetland vegetation types (Gallery forest and Veredas) for ecosystem functioning, and implications for future land-use and climate change in the Cerrado biome (Chapter 5). I emphasize the need for Brazilian environmental legislation to prioritize the integral conservation of periodically flooded areas.
Ultrasound-Assisted Synthesis of 2-Amino-1,3,4-Oxadiazoles via NBS-Mediated Oxidative Cyclization of Semicarbazones
Creators: name: Borsoi, Ana Flávia
name: Coldeira, Mateus Emanuel
name: Pissinate, Kenia
name: Macchi, Fernanda Souza
name: Luiz Augusto Basso
name: Diógenes Santiago Santos
name: Machado, Pablo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A ultrasound-assisted oxidative cyclization of semicarbazones using NBS in the presence of sodium acetate was established providing efficient and rapid access to a variety of 2-amino-1,3,4-oxadiazoles. Moreover, the new synthetic protocol provides a simple procedure utilizing a safer oxidizing system that affords the target products in high regioselectivity, satisfactory yields, and elevated purities.
Orientations récentes de l'Université catholique
Creators: name: Carrier, Hervé
Publisher: name: Didaskalia
Year: 1972

description: I. Les paradoxes de l'Université catholique. II. Le passé met en relief les mutations actuelles. 1) Un regard sur le passé; 2) Les mutations actuelles. III. Les Universités catholiques définissent leur identité: 1) L'idéal de l'Université catholique; 2) Traits caractéristiques de l'Université catholique; 3) Rapports de l'Université catholique avec les autorités de l'Eglise. IV. Conclusions et perspectives d'avenir.
description: Didaskalia, v. 2 n. 1 (1972)
Facile Synthesis of Novel Dihydroquinoline-3,3-Dicarbonitriles in the Presence of Glacial Acetic Acid as Catalyst Under Solvent-Free Conditions
Creators: name: Kanaani, Elham
name: Nasr-Esfahani, Masoud
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology

description: A series of novel dihydroquinoline derivatives were synthesized using malononitrile, 2-aminobenzoic acid and benzaldehydes in the presence of a catalytic amount of acetic acid, without the use of any additional co-catalyst, under solvent-free conditions. The reaction is characterized by high efficiency, easy workup, simple purification of the products and availability of catalyst.
O Salmo 126 e o terceiro êxodo
Creators: name: Castro, Joaquim Mendes De
Publisher: name: Didaskalia
Year: 1971

description: No séc. XVI os judeus da Penínsuia viveram momentos de grande agitação e expectativa, as quais tinham raízes no magistério de Isaac Abravanel e na actividade de José Nassi, ambos figuras notáveis da comunidade israelita em Portugal. O primeiro gozou de grande influência no ânimo de D. Afonso V e nalguns nobres da Corte, nomeadamente o duque de Bragança; mas veio a cair em desgraça no tempo de D. João II, suspeito de cumplicidade na conjura contra o rei. Fugindo ao braço justiceiro do monarca, exilou-se para Espanha e mais tarde para Itália, tendo-se fixado em Veneza, onde faleceu em 1508. Antes, porém, vivera 8 anos em Nápoles, os mais fecundos do seu labor de exegeta de invulgares recursos.
description: Didaskalia, v. 1 n. 2 (1971)
O missal votivo de Santa Cruz de Coimbra
Creators: name: Bragança, Joaquim De Oliveira
Publisher: name: Didaskalia
Year: 1971

description: Não pretendemos fazer aqui a análise interna do conteúdo litúrgico do missal votivo de Santa Cruz de Coimbra, mas tão sòmente dá-lo a conhecer, e deste modo fornecer um instrumento de trabalho aos especialistas da matéria.
description: Didaskalia, v. 1 n. 2 (1971)
Supramolecular dispersive liquid–liquid microextraction-based solidification of floating organic drops combined with electrothermal atomic absorption spectrometry for determination of chromium species
Creators: name: Tafti, Elaheh Nourbala
name: Shayessteh Dadfarnia
name: Shabani, Ali Mohammad Haji
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A simple, sensitive and reliable method has been developed for separation and preconcentration of chromium (VI) from aqueous samples before determination by electrothermal atomic absorption spectrometry. The method is based on the extraction of the hydrophobic complex of chromium (VI) with ammonium pyrrolidine dithiocarbamate in the coacervates made up of decanoic acid reverse micelles in the water–tetrahydrofuran mixture. Parameters affecting the extraction efficiency of the analyte were studied and optimised. Under the optimum conditions, the linear range, enhancement factor, the limit of detection and limit of quantification were found to be 0.008–0.4 µg L−1, 127, and 1.8 ng L−1 and 6.0 ng L−1, of Cr(VI), respectively. The relative standard deviation at the concentration level of 0.1 µg L−1 Cr(VI) (n = 6) was 4.2%. Total chromium was determined after the oxidation of Cr(III) to Cr(VI) with permanganate in acidic medium. The method was successfully applied to the determination of chromium species in water and human serum samples.
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
Creators: name: Akin, Debra
name: Keisin Wang, S
name: Habibzadegah-Tari, Pouran
name: Law, Brian
name: Ostrov, David
name: Li, Min
name: Yin, Xiao-Ming
name: Kim, Jae-Sung
name: Horenstein, Nicole
name: A Dunn Jr, William
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Autophagy has been implicated in the progression and chemoresistance of various cancers. In this study, we have shown that osteosarcoma Saos-2 cells lacking ATG4B, a cysteine proteinase that activates LC3B, are defective in autophagy and fail to form tumors in mouse models. By combining in silico docking with in vitro and cell-based assays, we identified small compounds that suppressed starvation-induced protein degradation, LC3B lipidation, and formation of autophagic vacuoles. NSC185058 effectively inhibited ATG4B activity in vitro and in cells while having no effect on MTOR and PtdIns3K activities. In addition, this ATG4B antagonist had a negative impact on the development of Saos-2 osteosarcoma tumors in vivo. We concluded that tumor suppression was due to a reduction in ATG4B activity, since we found autophagy suppressed within treated tumors and the compound had no effects on oncogenic protein kinases. Our findings demonstrate that ATG4B is a suitable anti-autophagy target and a promising therapeutic target to treat osteosarcoma.
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
Creators: name: Akin, Debra
name: Keisin Wang, S
name: Habibzadegah-Tari, Pouran
name: Law, Brian
name: Ostrov, David
name: Li, Min
name: Yin, Xiao-Ming
name: Kim, Jae-Sung
name: Horenstein, Nicole
name: A Dunn Jr, William
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Autophagy has been implicated in the progression and chemoresistance of various cancers. In this study, we have shown that osteosarcoma Saos-2 cells lacking ATG4B, a cysteine proteinase that activates LC3B, are defective in autophagy and fail to form tumors in mouse models. By combining in silico docking with in vitro and cell-based assays, we identified small compounds that suppressed starvation-induced protein degradation, LC3B lipidation, and formation of autophagic vacuoles. NSC185058 effectively inhibited ATG4B activity in vitro and in cells while having no effect on MTOR and PtdIns3K activities. In addition, this ATG4B antagonist had a negative impact on the development of Saos-2 osteosarcoma tumors in vivo. We concluded that tumor suppression was due to a reduction in ATG4B activity, since we found autophagy suppressed within treated tumors and the compound had no effects on oncogenic protein kinases. Our findings demonstrate that ATG4B is a suitable anti-autophagy target and a promising therapeutic target to treat osteosarcoma.
ХАЛҚАРО ҲУҚУҚНИНГ УМУМ ЭЪТИРОФ ЭТИЛГАН ПРИНЦИПЛАРИ ВА НОРМАЛАРИ ҲАМДА ХАЛҚАРО ШАРТНОМАЛАРИ ЎЗБЕКИСТОН ҲУҚУҚИЙ ТИЗИМИНИНГ ТАРКИБИЙ ҚИСМИ СИФАТИДА
Creators: name: Ганибаева, Сурайё
Publisher: name: Zenodo
Year: 2025

description: Халқаро муносабатларнинг ривожланиши, жаҳондаги глобаллашув жараёнлари халқаро ҳуқуқ ва чет эл ҳуқуқи нормалари турли мамлакатларда ҳуқуқни қўллаш жараёнларида, жумладан судлар томонидан қўлланилишини тақазо этмоқда. Шу ўринда турли миллий ва халқаро аҳамиятли низолар юзага келишида ва уларни ҳал этишда халқаро ҳуқуқ ва чет эл ҳуқуқи нормаларини қўллаш доирасида бир қатор амалий муаммоларни келиб чиқмоқда. Миллий суд статистикасига асосан охирги уч йилда иқтисодий судлар томонидан халқаро ҳуқуқ нормалари фақат хорижий суд ва халқаро арбитраж қарорларини тан олиш ва ижро этишда, чет эл элементи билан мураккаблашган ишларда эса чет эл ҳуқуқини қўллаш ҳолати фақат иккита иш юзасидан қўлланилганлиги маълум бўлди. Ушбу кўрсаткичлар мазкур масалаларнинг миллий қонунчилик ва суд амалиёти доирасида етарлича эътиборга олинмаслиги ҳамда тадқиқ этишда долзарблигини намоён қилади.
Transient Aerodynamic Atomisation Model to Predict Aerosol Droplet Size of Pressurised Metered Dose Inhalers (pMDI)
Creators: name: B. Gavtash
name: H. K. Versteeg
name: G. Hargrave
name: B. Myatt
name: D. Lewis
name: T. Church
name: G. Brambilla
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Pressurised metered dose inhalers (pMDI) produce large numbers of droplets with size of smaller than 5 μm to treat asthma and other pulmonary diseases. The mechanism responsible for droplet generation from bulk propellant liquid is poorly understood, mainly because the small length scales and short time scales make it difficult to characterise transient spray formation events. This paper describes the development and findings of a numerical atomisation model to predict droplet size of pharmaceutical propellants from first principles. In this model, the velocity difference between propellant vapour and liquid phase inside spray orifice leads to formation of wave-like instabilities on the liquid surface. Two variants of the aerodynamic atomisation model are presented based on assumed liquid precursor geometry: (1) cylindrical jet-shaped liquid ligaments surrounded by vapour annulus, (2) annular liquid film with vapour flow in the core. The growth of instabilities on the liquid precursors surfaces and the size of the subsequently formed droplets is predicted by numerical solutions of dispersion equations. The droplet size predictions were compared with Phase Doppler Anemometry (PDA) data and the predictions were in good agreement with the number mean diameter D10, which is representative of the respirable droplets. The temporal behaviour of droplet size production was captured consistently well during the period of the first 95% of the propellant mass emission. The outcome of our modelling activities also suggests that, in addition to saturated vapour pressure of the propellant, its viscosity and surface tension are also key properties that govern pMDI droplet size.
Influence de la fraction granulaire et de l'origine des granulats recyclés sur leurs propriétés
Creators: name: Zhao, Zengfeng
name: Courard, Luc
name: Michel, Frédéric
name: Remond, Sébastien
name: Damidot, Denis
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: De très grandes quantités de déchets de construction et de démolition sont produites chaque année. Afin de faire bon usage des granulats recyclés (GR) dans le béton, il est très important d’étudier l’influence de la fraction granulaire et de l’origine des granulats recyclés sur leurs propriétés. Dans cette étude, les granulats recyclés de blocs (GR_Blocs) et de hourdis (GR_Hourdis) ont été concassés et puis séparés en 4 fractions granulaires (0/2, 2/6,3, 6,3/14, 14/20mm). Chaque fraction granulaire des GR a été caractérisée. Les résultats montrent que la teneur en pâte de ciment durcie des GR augmente lorsque la taille des particules diminue. Les sables recyclés possèdent ainsi des teneurs en pâte de ciment nettement plus élevées que les gravillons recyclés. Les sables recyclés possèdent en particulier un coefficient d’absorption d’eau très élevé par rapport aux gravillons recyclés. Les valeurs de teneur en pâte de ciment durcie obtenues pour les GR_Blocs sont plus faibles que celles mesurées sur les GR_Hourdis, ce qui provient d’une plus faible quantité de pâte de ciment initiale du bloc. Les résultats montrent que pour toutes les fractions des GR, les GR_Hourdis sont plus anguleux que les GR_Blocs.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Schopenhauer e o estatuto do conhecer
Creators: name: Moura, José Barata
Publisher: name: Didaskalia
Year: 1971

description: La présente note a pour but de montrer, à propos de l'analyse du thème de la connaissance chez Schopenhauer, le besoin où l'on est de transcender ce niveau même du connaître représentatif pour pouvoir vraiment fonder une ontologie. En effet, ne nous donnant que des «objets», la connaissance transcendentale ne nous met en rapport qu'avec une région limitée du réel, laissant de côté, comme in-connus, soit le propre fondement matériel du connaître, soit la réalité qui se donne sous le mode de la «subjectivité».
description: Didaskalia, v. 1 n. 2 (1971)
Valorisation des déchets de brique rouge dans le béton à haute performance
Creators: name: Derabla, Riad
name: Bourema, Moufida
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Le recyclage des déchets est devenu aujourd'hui la bonne solution qui peut donner des ressources renouvelables et durables qui contribuent au processus de construction dans le domaine du génie civil de manière à protéger l'environnement. Les déchets de briques rouges (DBR) constituent une alternative intéressante dans ce cas, vu que ces déchets sont disponibles dans les chantiers de construction. Pour atteindre ces objectifs, nous avons essayé à travers ce travail d’ordre expérimental de valoriser le DBR et d’exprimer sa rentabilité en l’utilisant comme constituant dans le béton à haute performance. L'incorporation de DBR a été effectuée par la substitution du ciment en trois teneurs : 10%, 15% et 20%. La procédure expérimentale mise en place vise à déterminer les caractéristiques physiques et mécaniques du BHP à base du DBR et de les comparer avec celles du BHP de référence préparé sans DBR. Les caractéristiques étudiées sont : densité à l'état frais et à l’état durci, affaissement, vitesse de propagation d’ultrasons et résistances à la compression et à la traction par flexion à l'âge de 3 et 28 jours. Les résultats obtenus montrent que la substitution du ciment par une teneur de 10% de DBR est avantageuse tant à l’état frais qu’à l’état durci.….
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A
Creators: name: Lu, Yingying
name: Dong, Shichen
name: Hao, Baixia
name: Li, Chang
name: Zhu, Kaiyuan
name: Guo, Wenjing
name: Wang, Qian
name: Cheung, King-Ho
name: WM Wong, Connie
name: Wu, Wu-Tian
name: Markus, Huss
name: Yue, Jianbo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry

description: Autophagy is a catabolic lysosomal degradation process essential for cellular homeostasis and cell survival. Dysfunctional autophagy has been associated with a wide range of human diseases, e.g., cancer and neurodegenerative diseases. A large number of small molecules that modulate autophagy have been widely used to dissect this process and some of them, e.g., chloroquine (CQ), might be ultimately applied to treat a variety of autophagy-associated human diseases. Here we found that vacuolin-1 potently and reversibly inhibited the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes. Interestingly, vacuolin-1 was less toxic but at least 10-fold more potent in inhibiting autophagy compared with CQ. Vacuolin-1 treatment also blocked the fusion between endosomes and lysosomes, resulting in a defect in general endosomal-lysosomal degradation. Treatment of cells with vacuolin-1 alkalinized lysosomal pH and decreased lysosomal Ca2+ content. Besides marginally inhibiting vacuolar ATPase activity, vacuolin-1 treatment markedly activated RAB5A GTPase activity. Expression of a dominant negative mutant of RAB5A or RAB5A knockdown significantly inhibited vacuolin-1-induced autophagosome-lysosome fusion blockage, whereas expression of a constitutive active form of RAB5A suppressed autophagosome-lysosome fusion. These data suggest that vacuolin-1 activates RAB5A to block autophagosome-lysosome fusion. Vacuolin-1 and its analogs present a novel class of drug that can potently and reversibly modulate autophagy.
Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A
Creators: name: Lu, Yingying
name: Dong, Shichen
name: Hao, Baixia
name: Li, Chang
name: Zhu, Kaiyuan
name: Guo, Wenjing
name: Wang, Qian
name: Cheung, King-Ho
name: WM Wong, Connie
name: Wu, Wu-Tian
name: Markus, Huss
name: Yue, Jianbo
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry

description: Autophagy is a catabolic lysosomal degradation process essential for cellular homeostasis and cell survival. Dysfunctional autophagy has been associated with a wide range of human diseases, e.g., cancer and neurodegenerative diseases. A large number of small molecules that modulate autophagy have been widely used to dissect this process and some of them, e.g., chloroquine (CQ), might be ultimately applied to treat a variety of autophagy-associated human diseases. Here we found that vacuolin-1 potently and reversibly inhibited the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes. Interestingly, vacuolin-1 was less toxic but at least 10-fold more potent in inhibiting autophagy compared with CQ. Vacuolin-1 treatment also blocked the fusion between endosomes and lysosomes, resulting in a defect in general endosomal-lysosomal degradation. Treatment of cells with vacuolin-1 alkalinized lysosomal pH and decreased lysosomal Ca2+ content. Besides marginally inhibiting vacuolar ATPase activity, vacuolin-1 treatment markedly activated RAB5A GTPase activity. Expression of a dominant negative mutant of RAB5A or RAB5A knockdown significantly inhibited vacuolin-1-induced autophagosome-lysosome fusion blockage, whereas expression of a constitutive active form of RAB5A suppressed autophagosome-lysosome fusion. These data suggest that vacuolin-1 activates RAB5A to block autophagosome-lysosome fusion. Vacuolin-1 and its analogs present a novel class of drug that can potently and reversibly modulate autophagy.
The Hamas Narrative on October 7: What we did and why. What we want. What we did NOT do
Creators: name: Stockton, Ronald R.
Publisher: name: My University
Year: 2024
Subjects: subject: Hamas, ADL, Netanyahu, Rules of Good Studenting, beheaded babies, Rape, Oslo Accords, Hamas Charter of 1988, US Veto, Al Aqsa Mosque, Al Qassem Brigade, Jerusalem, International Criminal Court, Nakba.
subject: Social Sciences
subject: Political Science
subject: FOS: Political science

description: In January, 2024, Hamas released a document explaining their perspective on the attack of October 7, 2023. It addressed their logic, their strategy, their concerns, and the alternatives they had tried.
Parameter Expanded Algorithms for Bayesian Latent Variable Modeling of Genetic Pleiotropy Data
Creators: name: Xu, Lizhen
name: V. Craiu, Radu
name: Sun, Lei
name: D. Paterson, Andrew
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Motivated by genetic association studies of pleiotropy, we propose a Bayesian latent variable approach to jointly study multiple outcomes. The models studied here can incorporate both continuous and binary responses, and can account for serial and cluster correlations. We consider Bayesian estimation for the model parameters, and we develop a novel MCMC algorithm that builds upon hierarchical centering and parameter expansion techniques to efficiently sample from the posterior distribution. We evaluate the proposed method via extensive simulations and demonstrate its utility with an application to an association study of various complication outcomes related to Type 1 diabetes. This article has supplementary material online.
Parameter Expanded Algorithms for Bayesian Latent Variable Modelling of Genetic Pleiotropy Data
Creators: name: Sun, Lei
name: D. Paterson, Andrew
name: Xu, Lizhen
name: V. Craiu, Radu
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences

description: Motivated by genetic association studies of pleiotropy, we propose a Bayesian latent variable approach to jointly study multiple outcomes. The models studied here can incorporate both continuous and binary responses, and can account for serial and cluster correlations. We consider Bayesian estimation for the model parameters, and we develop a novel MCMC algorithm that builds upon hierarchical centering and parameter expansion techniques to efficiently sample from the posterior distribution. We evaluate the proposed method via extensive simulations and demonstrate its utility with an application to aa association study of various complication outcomes related to type 1 diabetes. This article has supplementary material online.
Decontamination of waterborne chemical pollutants by using atmospheric pressure nonthermal plasma: a review
Creators: name: Molina, Ricardo
name: Müller, Michael
name: Hijosa-Valsero, María
name: Montràs, Anna
name: Bayona, Josep M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology

description: Water pollution abatement is a topic of growing interest worldwide, mainly due to the large number of contaminants that continental waters may contain and the need for a safe wastewater reclamation and reuse in many sectors (agriculture, industry, aquifer recharge, and landscape restoration) and industrial recycling to reduce the end-of-pipe treatment. In this review, different advanced oxidation processes based on atmospheric pressure nonthermal plasma treatment for the removal of organic contaminants from waters are critically reviewed. Factors affecting the removal efficiency and energy yield are reviewed for specific organic contaminants (e.g. VOC, phenols, organic dyes, pharmaceuticals and personal care products, surfactants) and also for conventional water quality parameters (e.g. BOD, COD, TOC, , turbidity). Moreover, effects of operational modes (e.g. type of discharge, reactor configuration, plasma gas), catalytic processes (heterogeneous: TiO2, NiO, and homogeneous: Cu2+, Fe2+, ), post-treatment reactions and external oxidant addition (O3, H2O2) are also presented.
The experience of thriving at work for managers in the private and public sector
Creators: name: Judge, Emma
Publisher: name: Lancaster University
Year: 2020
Subjects: thriving
work
positive psychology
psychological safety
Meaningful work
positive organisational psychology

description: Thriving at work is a concept that has been influenced by a range of perspectives, including the thriving as a response to trauma and concepts of wellbeing, flourishing and happiness. The most influential theory of thriving at work in the extant literature as a combination of learning and vitality has informed a series of studies leading to a conceptual framework of antecedents, behaviours and outcomes. This thesis contends that thriving at work may differ across roles and explored the experience of thriving at work for managers in one public and one private sector organisation in the UK in order to understand their perceptions of cultural and individual factors that influence this experience. An integrated literature review identified the theoretical foundations of this debate, as well as critical questions to be addressed in this study, and informed the choice of a qualitative inquiry and a social constructivist paradigm. Semi-structured interviews incorporating the critical incident technique were carried out with 30 managers, and retrieved data was analysed using template analysis. This analysis identified three themes: trust as a foundation of thriving at work; making a difference as generating thriving at work; and the iterative, cumulative and emotive nature of thriving at work. The responses amplify the importance of immediate context, compared to broader cultural and demographic influences. Furthermore, the priority and weighting given to each factor varied significantly by individual, suggesting thriving at work is more personal than has been captured by current definitions and theories. A re-examination of the theoretical determinants of thriving at work suggests psychological safety and meaningful work could offer greater insight into the phenomenon for managers, and a new paradigm is proposed that reflects this theoretical position whilst placing greater emphasis on the individual nature of the concept.
Joint Modeling and Clustering Paired Generalized Longitudinal Trajectories With Application to Cocaine Abuse Treatment Data
Creators: name: Huang, Hui
name: Li, Yehua
name: Guan, Yongtao
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Pharmacology

description: In a cocaine dependence treatment study, we have paired binary longitudinal trajectories that record the cocaine use patterns of each patient before and after a treatment. To better understand the drug-using behaviors among the patients, we propose a general framework based on functional data analysis to jointly model and cluster these paired non-Gaussian longitudinal trajectories. Our approach assumes that the response variables follow distributions from the exponential family, with the canonical parameters determined by some latent Gaussian processes. To reduce the dimensionality of the latent processes, we express them by a truncated Karhunen-Lóeve (KL) expansion allowing the mean and covariance functions to be different across clusters. We further represent the mean and eigenfunctions functions by flexible spline bases, and determine the orders of the truncated KL expansions using data-driven methods. By treating the cluster membership as a missing value, we cluster the cocaine use trajectories by a likelihood-based approach. The cluster membership and parameter estimates are jointly estimated by a Monte Carlo EM algorithm with Gibbs sampling steps. We discover subgroups of patients with distinct behaviors in terms of overall probability to use, binge verses periodic use pattern, etc. The joint modeling approach also sheds new lights on relating relapse behavior to baseline pattern in each subgroup. Supplementary materials for this article are available online.
Ambiguous influences of omnivorous fish on trophic cascade and alternative states: Implications for biomanipulation from an ecological model
Creators: name: Li, Junmin
name: Huang, Ping
name: Zhao, Zhuangming
name: Zhang, Renduo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: An ecological model was developed to systematically analyze the comprehensive influence of omnivory level and predation intensity of fish on the dynamic state and strength of trophic cascade of a lake ecosystem. Results showed that a higher fish omnivory level reduced the strength of trophic cascade and increased the occurrence of alternative states, while an increase in predation intensity resulted in opposite effects. With the combination of these two factors, the occurrence of alternative states was dependent on the relative increase in the predation intensity. The model was further applied to a subtropical shallow lake in China. Modeling results revealed that the heavy stock of omnivorous fish in the lake increased the occurrence of alternative states and decreased the strength of trophic cascade. Results indicated that the long-term effect of biomanipulation would be significant and therefore high rates of fish removal would be required. The information from this study indicated the importance of understanding the dynamic state and strength of trophic cascade when predicting the long-term effects of biomanipulation.
Recent (2008–2012) seaweed flora of Hainan Island, South China Sea
Creators: name: A. Titlyanov, Eduard
name: V. Titlyanova, Tamara
name: Li, Xiubao
name: L. Kalita, Tatyana
name: Huang, Hui
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology

description: During the period from 2008 to 2012, algal samplings were conducted off Hainan Island (China) at seven localities. A total of 252 benthic macroalgal taxa were collected where 53% were reds, 31% greens and 16% browns. The largest numbers of species belonged to the families Rhodomelaceae, Ceramiaceae, Corallinaceae (Rhodophyta), Cladophoraceae, Ulvaceae, Caulerpaceae (Chlorophyta), Sargassaceae and Dictyotaceae (Heterokontophyta). The analysis of the floristic diversity and composition during 2008–2012 revealed similarity to that of other large islands in the tropical zone of the Indo-Pacific where coral reefs are the main ecosystem. As was shown by comparative analysis of algal species composition and form diversity between the periods of 1990/1992 and 2008–2012, maximum similarity boundary values between the floras amounted to 66% (Rh), 65% (Ch) and 55% (Phaeophyceae, Ph). These decadal changes resulted in the loss of long-living volumetric forms of macrophytic algae with an increase in the number of fine filamentous algal forms, with tubular and blade-like thalli, as seawater pollution and probably natural catastrophes occurred during the period between the 1990s and 2000s.
Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment
Creators: name: Tian, Yong-qi
name: Lin, Xiu-Ping
name: Liu, Juan
name: Kaliyaperumal, Kumaravel
name: Ai, Wen
name: Ju, Zhi-ran
name: Yang, Bin
name: Wang, Junfeng
name: Yang, Xian-Wen
name: Liu, Yonghong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( − )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (1–9) were evaluated for antibacterial activity.
Comparative proteomic analysis of Arabidopsis thaliana roots between wild type and its salt-tolerant mutant
Creators: name: Guo, Meili
name: Li, Hua
name: Li, Lei
name: Gao, Weixi
name: Xu, Yulan
name: Zhou, Chunxi
name: Liu, Xin
name: Cheng, Xuemei
name: Liu, Fujun
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Two-dimensional electrophoresis (2-DE) showed the variation expression of Arabidopsis thaliana root proteins between wild type and its salt-tolerant mutant obtained from cobalt-60 γ ray radiation. Forty-six differential root protein spots were reproducibly presented on 2-DE maps, and 29 spots were identified by matrix assisted laser desorption ionization-time of flight/time of flight mass spectrometry (MS). Fifteen protein spots corresponding to 10 proteins, and 14 protein spots corresponding to 9 proteins were constitutively up-regulated and down-regulated in the salt-tolerant mutant root. Bioinformatic analysis indicated that those differential proteins might be involved in the regulation of redox homeostasis, nucleotide metabolism, signal transduction, stress response and defense, carbohydrate metabolism, and cell wall metabolism. Peroxidase 22 might be a versatile enzyme and might play dual roles in both cell wall metabolism and regulation of redox homeostasis. Our work provides not only new insights into salt-responsive proteins in root, but also the potential salt-tolerant targets for further dissection of molecular mechanism adapted by plants during salt stress.
Unexpected transformation of black hole quenchers in electrophoretic purification of the fluorescein-containing TaqMan probes
Creators: name: Ryabinin, Vladimir A.
name: Kostina, Elena V.
name: Sinyakov, Alexander N.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The fluorescence quenchers BHQ1 and BHQ2 can be modified by trace amounts of ammonium persulfate, used for initiating gel polymerization, in electrophoretic purification of TaqMan probes using a denaturing polyacrylamide gel. The case study of BHQ1 quencher has demonstrated that a Boyland–Sims reaction proceeds in the presence of ammonium persulfate to give the corresponding sulfate. The absorption maximum of the resulting quencher shifts to the short-wavelength region relative to the absorption maximum of the initial BHQ1. The TaqMan probe containing such a quencher is less efficient as compared with the probe carrying an unmodified BHQ1. The presence of fluorescein in TaqMan probe plays decisive role in this transformation: the quencher modification proceeds at a considerably lower rate when the fluorescein is absent or replaced with a rhodamine dye (for example, R6G). It is assumed that the observed reaction can take place in two ways—both in darkness and in the reaction of the quencher in an excited state due to energy transfer from the fluorophore irradiated by light.
title: Préface_Manuel de l'amateur de reliures armoriées françaises . Quatrième série
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Préface
description: ID_PARA_00969
Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline
Creators: name: Li, Guanghui
name: Wang, Nannan
name: Li, Xiaohua
name: Liu, Ping
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: In the presence of silver nanoparticles, fenoterol and orciprenaline were shown to enhance the chemiluminescence of the potassium periodate-luminol chemiluminescence system. Therefore, a new method for the determination of fenoterol and orciprenaline was developed. The catalytic effect of silver nanoparticles upon the reaction of potassium periodate and luminol was studied. The chemiluminescence characteristics of potassium periodate, luminal, and silver nanoparticles with fenoterol and orciprenaline were studied. Using univariate design, the factors influencing chemiluminescence were optimized. The optimal experimental conditions were 60 µmol L−1 of potassium periodate, 80 µmol L−1 of luminol, 6 mmol L−1 of sodium hydroxide, 2 µmol L−1 of silver nanoparticles, and a flow rate of 2.0 mL min−1. The system permitted 200 injections per hour. The linear dynamic ranges were between 0.6 and 10 ng mL−1 for fenoterol and 0.4 and 10 ng mL−1 for orciprenaline, with limits of detection of 0.1 ng mL−1 for fenoterol and 0.1 ng mL−1 for orciprenaline. The method was successfully employed to determine fenoterol and orciprenaline with recoveries in the range of 97.5% to 99.9%. Chemiluminescence reaction mechanisms for these systems were proposed.
Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation
Creators: name: Pei-Shin Jiang
name: Hsin-Yu Tsai
name: Drake, Philip
name: Fu-Nien Wang
name: Chi-Shiun Chiang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Marine Biology
subject: Cancer

description: The gadolinium-doped iron oxide nanoparticles (GdIONP) with greater specific power adsorption rate (SAR) than Fe3O4 was developed and its potential application in tumour therapy and particle tracking were demonstrated in transgenic adenocarcinoma of the mouse prostate C1 (TRAMP-C1) tumours. The GdIONPs accumulated in tumour region during the treatment could be clearly tracked and quantified by T2-weighted MR imaging. The therapeutic effects of GdIONP-mediated hyperthermia alone or in combination with radiotherapy (RT) were also evaluated. A significant increase in the tumour growth time was observed following the treatment of thermotherapy (TT) only group (2.5 days), radiation therapy only group (4.5 days), and the combined radio-thermotherapy group (10 days). Immunohistochemical staining revealed a reduced hypoxia region with vascular disruption and extensive tumour necrosis following the combined radio-thermotherapy. These results indicate that GdIONP-mediated hyperthermia can improve the efficacy of RT by its dual functions in high temperature (temperature greater than 45 °C)-mediated thermal ablation and mild-temperature hyperthermia (MTH) (temperature between 39 and 42 °C)-mediated reoxygenation.
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1
Creators: name: Zou, Jianqiu
name: Zhang, Deli
name: Qin, Guang
name: Chen, Xiangming
name: Wang, Hongmin
name: Zhang, Dong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: DNA damage response (DDR) and the centrosome cycle are 2 of the most critical cellular processes affecting the genome stability in animal cells. Yet the cross-talks between DDR and the centrosome are poorly understood. Here we showed that deficiency of the breast cancer 1, early onset gene (BRCA1) induces centrosome amplification in non-stressed cells as previously reported while attenuating DNA damage-induced centrosome amplification (DDICA) in cells experiencing prolonged genotoxic stress. Mechanistically, the function of BRCA1 in promoting DDICA is through binding and recruiting polo-like kinase 1 (PLK1) to the centrosome. In a recent study, we showed that FancJ also suppresses centrosome amplification in non-stressed cells while promoting DDICA in both hydroxyurea and mitomycin C treated cells. FancJ is a key component of the BRCA1 B-complex. Here, we further demonstrated that, in coordination with BRCA1, FancJ promotes DDICA by recruiting both BRCA1 and PLK1 to the centrosome in the DNA damaged cells. Thus, we have uncovered a novel role of BRCA1 and FancJ in the regulation of DDICA. Dysregulation of DDR or centrosome cycle leads to aneuploidy, which is frequently seen in both solid and hematological cancers. BRCA1 and FancJ are known tumor suppressors and have well-recognized functions in DNA damage checkpoint and DNA repair. Together with our recent findings, we demonstrated here that BRCA1 and FancJ also play an important role in centrosome cycle especially in DDICA. DDICA is thought to be an alternative fail-safe mechanism to prevent cells experiencing severe DNA damage from becoming carcinogenic. Therefore, BRCA1 and FancJ are potential liaisons linking early DDR with the DDICA. We propose that together with their functions in DDR, the role of BRCA1 and FancJ in the activation of DDICA is also crucial for their tumor suppression functions in vivo.