cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
Creators: name: Yohe, Marielle E
name: Rossman, Kent L
name: Mitin, Natalia
name: Sondek, John
name: Der, Channing J
name: Betts, Laurie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor suppressor. Here we show that binding of the armadillo repeats of APC to a ‘core APC-binding’ (CAB) motif within ASEF, or truncation of the SH3 domain of ASEF, relieves autoinhibition, allowing the specific activation of CDC42. Structural determination of autoinhibited ASEF reveals that the SH3 domain forms an extensive interface with the catalytic DH and PH domains to obstruct binding and activation of CDC42, and the CAB motif is positioned adjacent to the SH3 domain to facilitate activation by APC. In colorectal cancer cell lines, full-length, but not truncated, APC activates CDC42 in an ASEF-dependent manner to suppress anchorage-independent growth. We therefore propose a model in which ASEF acts as a tumor suppressor when activated by APC and inactivation of ASEF by mutation or APC truncation promotes tumorigenesis.
Tourism Experience Development in Alberta During the Coronavirus Pandemic
Creators: Kos, Krasna
Publisher: name: University of Alberta Library
Year: 2022

In an increasingly competitive global marketplace, the need for destinations to create compelling and memorable experiences to differentiate themselves and power economic growth has become an important destination development strategy following significant tourism industry disruption resulting from the Coronavirus pandemic. The purpose of this study was to explore key concepts in tourism experience development and gather knowledge on how tourism experiences, markets, and consumer behaviour have changed in Alberta, Canada because of the COVID-19 pandemic. Using exploratory qualitative methodology, this study involved semi-structured interviews with 15 tourism operators in Alberta to explore the evolution of tourism experiences as the province emerges from the pandemic.

The interview results found operators shifted their focus to domestic visitor markets during the pandemic, but following the pandemic international visitation is still lagging behind pre-pandemic levels and corporate markets have been slow to return. Tourism operators reported both pent-up demand for experiences as well as audiences who are still hesitant to travel and gather. Consumer buying habits have become more non-committal, trending towards last-minute purchasing and flexible buying options. Further to this, the tourism experience adaptations that occurred during the pandemic resulted from COVID-19 safety measures such as masking, hand sanitization, reducing capacities, and distancing guests. Technology accelerated as a driver of innovation and brought about improvements in visitor experiences, allowed businesses to reach more diverse and international audiences, and improved accessibility for some audiences. However, effective use of technology was challenging for some and there is a strong desire by tourism operators to go back to the way things were done pre-pandemic.

This was an important study not only to understand the experiences of tourism operators in Alberta but to bring forth timely considerations for the future of Alberta’s tourism industry such as meeting consumers’ diverse needs, bringing back skilled labour, building adaptive business strategies, and ensuring personalization is backed by data. The question overwhelmingly on tourism operators’ minds is “what do people want from their experiences now?” As we enter an era of regrowth for Alberta’s tourism industry, the time is ripe for the creation of impactful and engaging experiences that strengthen Alberta’s tourism economy and inspire the world to visit Alberta. The question we must ask ourselves is how do we best support the industry in developing memorable Canadian experiences?
Crystal structure of the multifunctional Gβ5–RGS9 complex
Creators: name: Siderovski, David P
name: Gershburg, Svetlana
name: Snyder, Jason T
name: Cheever, Matthew L
name: Sondek, John
name: Harden, T Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein α (Gα) subunits and are vital for proper signaling kinetics downstream of G protein–coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein β5 (Gβ5) subunit through an internal G protein γ (Gγ)-subunit–like (GGL) domain. Here we present the 1.95-Å crystal structure of the Gβ5–RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.
Letter from Joseph Logan to Claudia Nissley, Rehabilitation of Building 902, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Department of the Air Force
Year: 1991
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Military Structure
valueUri: https://core.tdar.org/browse/site-type/322/military-structure
subject: Building 902
valueUri: https://core.tdar.org/browse/other-keyword/146467/building-902
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Randolph Air Force Base has begun an undertaking that may affect Building 902, which is potentially eligible for listing on the National Register of Historic Places. It has been discovered that the Section 106 process was not completed prior to the expenditure of Federal funds for the subject undertaking. This letter was written in an attempt to correct this mistake. This letter is part of correspondence and extensive summary documentation on an undertaking in progress to rehabilitate Building 902, Randolph Air Force Base, Texas. The letters also indicate that the Section 106 process was not completed prior to the expenditure of Federal funds for the subject undertaking.
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
Creators: name: Gomes, Michelle M
name: Herr, Andrew B
name: Xu, Zhen
name: Kohli, Ekta
name: Misra, Saurav
name: Nix, Jay C
name: Page, Richard C
name: Patterson, Cam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Cochaperones are essential for Hsp70/Hsc70-mediated folding of proteins and include nucleotide exchange factors (NEF) that assist protein folding by accelerating ADP/ATP exchange on Hsp70. The cochaperone Bag2 binds misfolded Hsp70 clients and also acts as a NEF, but the molecular basis of its functions is unclear. We show that, rather than being a member of the Bag domain family, Bag2 contains a new type of Hsp70 NEF domain, which we call the “Brand New Bag” (BNB) domain. Free and Hsc70-bound crystal structures of Bag2-BNB show its dimeric structure in which a flanking linker helix and loop bind to Hsc70 to promote nucleotide exchange. NMR analysis demonstrates that the client-binding sites and Hsc70 interaction sites of Bag2-BNB overlap, and that Hsc70 can displace clients from Bag2-BNB, indicating a distinct mechanism for the regulation of Hsp-70-mediated protein folding by Bag2.
Magnetic-field-induced electronic instability of Weyl-like fermions in compressed black phosphorus
Creators: name: Zheng, Lixuan
name: Luo, Kaifa
name: Sun, Zeliang
name: Zhao, Dan
name: Li, Jian
name: Song, Dianwu
name: Li, Shunjiao
name: Kang, Baolei
name: Nie, Linpeng
name: Shan, Min
name: Wu, Zhimian
name: Zhou, Yanbing
name: Dai, Xi
name: Weng, Hongming
name: Yu, Rui
name: Wu, Tao
name: Chen, Xianhui
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Revealing the role of Coulomb interaction in topological semimetals with Dirac/Weyl-like band dispersion shapes a new frontier in condensed matter physics. Topological node-line semimetals (TNLSMs), anticipated as a fertile ground for exploring electronic correlation effects due to the anisotropy associated with their node-line structure, have recently attracted considerable attention. In this study, we report an experimental observation for correlation effects in TNLSMs realized by black phosphorus (BP) under hydrostatic pressure. By performing a combination of nuclear magnetic resonance measurements and band calculations on compressed BP, a magnetic-field-induced electronic instability of Weyl-like fermions is identified under an external magnetic field parallel to the so-called nodal ring in the reciprocal space. Anomalous spin fluctuations serving as the fingerprint of electronic instability are observed at low temperatures, and they are observed to maximize at approximately 1.0 GPa. This study presents compressed BP as a realistic material platform for exploring the rich physics in strongly coupled Weyl-like fermions.
description: 10 pages, 4 figures
Кадровое обеспечение сельского хозяйства Дальнего Востока в годы Великой Отечественной войны
Creators: name: Дурнев Алексей Яковлевич
name: Ткачева Г.А.
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: В статье рассматриваются государственные мероприятия по обеспечению квалифицированными кадрами сельскохозяйственного производства в условиях военного времени. Раскрывается функционирование региональной системы обучения массовым сельскохозяйственным профессиям и ее результативность. Особое внимание уделяется ситуации, сложившейся в обеспечении аграрного сектора региона дипломированными специалистами сельского хозяйства и руководящими работниками низового звена.
«Болонский процесс» и некоторые вопросы преподавания иностранных языков в неязыковых вузах
Creators: name: Карпова Татьяна Степановна
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: В статье рассматриваются преимущества и опасности процесса глобализации образования, а также некоторые проблемы, которые необходимо учитывать нашим преподавателям, решающим вопросы подготовки всесторонне развитых специалистов.
Space and habitat use of polar bears (Ursus maritimus) in Davis Strait in relation to sea ice conditions and harp seals (Pagophilus groenlandicus)
Creators: Thelin, Larissa
Publisher: name: University of Alberta Library
Year: 2022

Patterns of space use and habitat selection by polar bears (Ursus maritimus) vary among subpopulations where they have been studied. The Davis Strait subpopulation is one of the least researched polar bear subpopulations and their spatial ecology is largely unknown. As an obligate carnivore, polar bears rely largely on seals as their primary prey, yet predator-prey spatial relationships are poorly studied. In order to assess the spatial relationship between polar bears in Davis Strait and harp seals, one of their primary prey, we first analyzed trends in sea ice dynamics to understand sea ice conditions that may affect each species’ distribution. We found that the availability of sea ice for polar bears decreased over time, resulting in a significant lengthening of the ice-free season (10.9 d/decade). We used remotely sensed imagery of sea ice (1979 – 2021) in relation to the movements of both polar bears (n=27) and harp seals (n=29) as determined by satellite telemetry. We calculated annual home range sizes, seasonal movement rates, and seasonal directionality for the Davis Strait subpopulation of polar bears (1991 – 2001). The mean annual home range size of polar bears was 101,775 km2 (range=699-280,539 km2) but varied with the statistical method used. Bears travelled a mean speed of 0.53 km/h (range=0-2.19 km/h) with the fastest rates in winter and slowest in freeze-up. Bears showed significant southward orientation during break-up and northward orientation during freeze-up but had no significant orientation in winter. We used resource selection functions to analyze seasonal habitat selection for both polar bears (1991 – 2001) and harp seals (1993 – 2005). The only covariate important to bear resource selection was distance to land during break-up, with null models placing top for the other seasons. For harp seals, ocean depth, sea ice concentration, distance to land, distance to open water, and distance to open water 2 were selected but their importance varied by season. To investigate the seasonal overlap in habitat between these two species, we compared resource selection and mapped seasonal kernel density overlap. We found that sea ice season affected space use and habitat selection for both species. Polar bears and harp seals were more likely to overlap during break-up and freeze-up but did so to a greater extent during freeze-up, but this may be due to sampling methods. This study illustrates the need to collect more polar bear telemetry data, particularly for those in less-studied regions. With climate change altering available habitats for all polar bear subpopulations, there is an urgency to understand how they are being spatially affected by a changing environment and our study provides a starting point for future studies.
Интегрированные занятия по немецкому языку в Дальневосточном государственном аграрном университете
Creators: name: Елуфимова Ольга Леонидовна
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: В статье анализируется вопрос взаимосвязи иностранного языка с другими учебными дисциплинами, обсуждается возможность и необходимость проведения интегрированных занятий в неязыковом вузе. Предлагается разработка интегрированного занятия по теме «Электрический ток».
Non-LTE Abundances in OB stars: Preliminary Results for 5 Stars in the Outer Galactic Disk
Creators: name: Bragança, G. A.
name: Lanz, T.
name: Daflon, S.
name: Cunha, K.
name: Garmany, C. D.
name: Glaspey, J. W.
name: Fernandes, M. Borges
name: Oey, M. S.
name: Bensby, T.
name: Hubeny, I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The aim of this study is to analyse and determine elemental abundances for a large sample of distant B stars in the outer Galactic disk in order to constrain the chemical distribution of the Galactic disk and models of chemical evolution of the Galaxy. Here, we present preliminary results on a few stars along with the adopted methodology based on securing simultaneous O and Si ionization equilibria with consistent NLTE model atmospheres.
description: 2 pages, 1 figure. To be published in the IAU Symposium 307 proceedings
Telomeric circles: universal players in telomere maintenance?
Creators: name: Kramara, Juraj
name: Griffith, Jack D
name: Tomaska, Lubomir
name: Nosek, Jozef
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To maintain linear DNA genomes, organisms have evolved numerous means of solving problems associated with DNA ends (telomeres), including telomere-associated retrotransposons, palindromes, hairpins, covalently bound proteins and the addition of arrays of simple DNA repeats. Telomeric arrays can be maintained through various mechanisms such as telomerase activity or recombination. The recombination-dependent maintenance pathways may include telomeric loops (t-loops) and telomeric circles (t-circles). The potential involvement of t-circles in telomere maintenance was first proposed for linear mitochondrial genomes. The occurrence of t-circles in a wide range of organisms, spanning yeasts, plants and animals, suggests the involvement of t-circles in many phenomena including the alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD). In this Perspective, we summarize these findings and discuss how t-circles may be related to t-loops and how t-circles may have initiated the evolution of telomeres.
Letter from Emmitt Smith to Curtis Tunnell, Install Privacy Fencing, Randolph Air Force Base, Texas
Creators: name: Smith, Emmitt G.
Publisher: name: Randolph Air Force Base
Year: 1996
Subjects: subject: Randolph Field Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/83364/randolph-field-historic-landmark-district
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Fencing
valueUri: https://core.tdar.org/browse/other-keyword/112368/fencing
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This letter from Randolph Air Force Base provides summary documentation for the Texas Historical Commission's review. The proposed undertaking involves the installation of privacy fencing at Randolph Air Force Base and has the determination of no adverse effect on the property or the district.
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA
Creators: name: Griffith, Jack D
name: Compton, Sarah A
name: Lekomtsev, Sergey
name: West, Stephen C
name: Petronczki, Mark
name: McIlwraith, Michael J
name: Thorslund, Tina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Individuals with BRCA2 mutations are predisposed to breast cancers owing to genome instability. To determine the functions of BRCA 2, the human protein was purified. It was found to bind selectively to single-stranded DNA (ssDNA), and to ssDNA in tailed duplexes and replication fork structures. Monomeric and dimeric forms of BRCA 2 were observed by EM. BRCA 2 directed the binding of RA D51 recombinase to ssDNA, reduced the binding of RA D51 to duplex DNA and stimulated RA D51-mediated DNA strand exchange. These observations provide a molecular basis for the role of BRCA 2 in the maintenance of genome stability.
EYE-SYNC Saccade Outcomes and Health/Demographic Factors in CFL Athletes
Creators: Ree-Fedun, Bradyn
Publisher: name: University of Alberta Library
Year: 2022

The purpose of the present study was to examine the relationship between demographic and health factors, and oculomotor functioning during baseline testing in professional athletes. Four hundred twenty-eight male athletes consented and participated in the baseline concussion assessments of the Canadian Football League (CFL). Athletes ranged from 21 to 40 years of age (M =26.44, SD =2.873), and reported a history of 0, 1, or 2+ sport-related concussions (SRCs). All athlete participants completed the Head Check questions of demographics and medical history, and the EYE-SYNC saccade test to explore how the presence of a history of concussions, Attention-Deficit/Hyperactivity Disorder (ADHD), Learning Disability (LD), age, and post-exertion influenced baseline measures of oculomotor functioning using the EYE-SYNC saccade outcomes of accuracy and precision. Correlations revealed no significant relationships between combined vertical and horizontal saccade outcomes (LeftAccuracyXY, LeftPrecisionXY, RightAccuracyXY, RightPrecisionXY) and the demographic/health variables (p > .05). Independent t-tests indicated no significant differences in mean saccade performance between athletes with and without ADHD and/or LD (p > .05). Furthermore, three-way multiple analysis of variance (MANOVA) run with age group (21-25, 26-30, 31-40) and concussion group (0, 1, 2+) revealed no main effects of age, F(8, 844) = .914, p = .504, Wilks’ = .983, partial η2 = .0) or history of concussion, F(8, 510) = .856, p = .554, Wilks’ = .974, partial η2 = .013). A one-way repeated measures analysis of variance (MANOVA) revealed no significant differences from pre- to post-exertion assessments, F(4, 56) = .411, p = .800, Wilks’ = .971. The oculomotor functioning of CFL athletes at baseline, measured using the EYE-SYNC saccade task, does not appear to be influenced by a history of concussion, ADHD, LD, age, or physical exertion. This information may help professionals with their clinical decision-making regarding the diagnosis of SRCs, and return-to-play.
Sustained active site rigidity during synthesis by human DNA polymerase μ
Creators: name: Ramsden, Dale A
name: Bebenek, Katarzyna
name: Moon, Andrea F
name: Pedersen, Lars C
name: Kunkel, Thomas A
name: Pryor, John M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: DNA polymerase mu (Pol μ) is the only template-dependent human DNA polymerase capable of repairing double strand DNA breaks (DSBs) with unpaired 3′-ends in non-homologous end joining (NHEJ). To probe this function, we structurally characterized Pol μ’s catalytic cycle for single nucleotide incorporation. These structures indicate that, unlike other template-dependent DNA polymerases, there are no large-scale conformational changes in protein subdomains, amino acid side chains, or DNA upon dNTP binding or catalysis. Instead, the only major conformational change is seen earlier in the catalytic cycle, when the flexible Loop1 region repositions upon DNA binding. Pol μ variants with changes in Loop1 have altered catalytic properties and are partially defective in NHEJ. The results indicate that specific Loop1 residues contribute to Pol μ’s unique ability to catalyze template-dependent NHEJ of DSBs with unpaired 3′-ends.
A complete study of the lack of compactness and existence results of a Fractional Nirenberg Equation via a flatness hypothesis: Part I
Creators: name: Abdelhedi, W.
name: Chtioui, H.
name: Hajaiej, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35J60, 35B33, 35B99, 35R11, 58E30

description: In this paper we establish existence results for the Fractional Nirenberg Equation via the flatness hypothesis. We have been able to include the Morse functions in our study. This extends the previous results obtained bY Yan Yan Li and Coauthors. We also discuss the loss of compactness. Our method is self-contained and hinges on the breakthrough results of Bahri andBahri and Coron.
description: 34 pages. arXiv admin note: text overlap with arXiv:math/0305197 by other authors
Topic Modelling via Community Mining of Term Co-occurrence Networks
Creators: Austin, Eric
Publisher: name: University of Alberta Library
Year: 2022

Topic modelling seeks to uncover the conceptual and thematic content of collections of documents. These topics can be used as features for document indexing and classification. However, topic models are increasingly important as tools of applied research. As we seek to develop agents capable of having real conversations with humans, topic models are needed to control topic drift and guide the conversation. Unfortunately, the most popular topic models in use today do not provide a suitable topic structure for these purposes and the state-of-the-art models based on neural networks suffer from many of the same drawbacks while requiring specialized hardware and many hours to train.

We take a fundamentally different approach to topic modelling. Our algorithm, Community Topic, is based on mining communities of terms from term-occurrence networks extracted from the documents. In addition to providing interpretable collections of terms as topics, the network representation provides a natural topic structure. The topics form a network, so topic similarity is inferred from the weights of the edges between them. Super-topics can be found by iteratively applying community detection on the topic network, grouping similar topics together. Sub-topics can be found by iteratively applying community detection on a single topic community. This can be done dynamically, with the user or conversation agent moving up and down the topic hierarchy as desired.

We evaluate Community Topic against two contenders. We find that our algorithm detects topics with the highest coherence as measured by two standard automated metrics. Our algorithm has the fastest run time and detects topics in few seconds with no specialized hardware required. It is hyperparameter free and can detect topics at multiple scales. It finds coherent sub- and super-topics at multiple levels. This makes Community Topic an ideal topic modelling algorithm for both applied research and practical applications like conversational agents.
Multiple phase estimation in quantum cloning machines
Creators: name: Yao, Yao
name: Ge, Li
name: Xiao, Xing
name: Wang, Xiao-guang
name: Sun, Chang-pu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Since the initial discovery of the Wootters-Zurek no-cloning theorem, a wide variety of quantum cloning machines have been proposed aiming at imperfect but optimal cloning of quantum states within its own context. Remarkably, most previous studies have employed the Bures fidelity or the Hilbert-Schmidt norm as the figure of merit to characterize the quality of the corresponding cloning scenarios. However, in many situations, what we truly care about is the relevant information about certain parameters encoded in quantum states. In this work, we investigate the multiple phase estimation problem in the framework of quantum cloning machines, from the perspective of quantum Fisher information matrix (QFIM). Focusing on the generalized d-dimensional equatorial states, we obtain the analytical formulas of QFIM for both universal quantum cloning machine (UQCM) and phase-covariant quantum cloning machine (PQCM), and prove that PQCM indeed performs better than UQCM in terms of QFIM. We highlight that our method can be generalized to arbitrary cloning schemes where the fidelity between the single-copy input and output states is input-state independent. Furthermore, the attainability of the quantum Cramer-Rao bound is also explicitly discussed.
description: 10 pages, 3 figures. Any suggestions and comments are welcome!
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Creators: name: McCorvy, John D
name: Roth, Bryan L
name: Huang, Xi-Ping
name: Sassano, Maria F
name: Lansu, Katherine
name: Kroeze, Wesley K
name: Sciaky, Noah
name: Giguère, Patrick M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: G protein-coupled receptors (GPCRs) are essential mediators of cellular signaling and important targets of drug action. Of the approximately 350 non-olfactory human GPCRs, more than 100 are still considered “orphans” as their endogenous ligand(s) remain unknown. Here, we describe a unique open-source resource that provides the capacity to interrogate the druggable human GPCR-ome via a G protein-independent β-arrestin recruitment assay. We validate this unique platform at more than 120 non-orphan human GPCR targets, demonstrate its utility for discovering new ligands for orphan human GPCRs, and describe a method (PRESTO-TANGO; Parallel Receptor-ome Expression and Screening via Transcriptional Output - TANGO) for the simultaneous and parallel interrogation of the entire human GPCR-ome.
title: Literary Primary Sources: manuscripts and papyri
title: A textbook on digital humanities
titleType: AlternativeTitle
title: Η φιλολογία και οι πρωτογενείς πηγές της: πάπυροι και χειρόγραφα
title: Ένα εγχειρίδιο στις ψηφιακές ανθρωπιστικές επιστήμες
titleType: AlternativeTitle
Creators: name: Konstantinidou, Maria
name: Bouses, Stamatis
Publisher: name: Kallipos, Open Academic Editions
Year: 2022
Subjects: Ψηφιακές Ανθρωπιστικές Επιστήμες
Παπυρολογία
Παλαιογραφία
Ψηφιοποίηση χειρόγραφων τεκμηρίων
Μηχανική ανάγνωση χειρόγραφου κειμένου
Ψηφιακές εκδόσεις
Ψηφιακή απεικόνιση
Ψηφιακή Παπυρολογία
Ψηφιακή Παλαιογραφία
Ψηφιακή διαχείριση πολιτιστικής κληρονομιάς
Digital Humanities
Papyrology
Palaeography
Manuscript digitization
Handwritten Text Recognition
Digital Editions
Digital Imaging
Digital Papyrology
Digital Palaeography
Digital Cultural Heritage

description: This is a handbook on digital methods in the disciplines of papyrology and paleography. It presents aspects of digitization of ancient textual objects, management of digitized manuscripts, new research techniques offered by modern technologies, as well as methods of accessing these records by researchers and the public. It is aimed at readers with a background in humanities and no technical training. This book offers an overview of digital papyrology and palaeography. It examines issues of preservation, digitization, management of digitized records, machine handwritten text recognition and analysis, as well as aspects of digital scholarly editions. It also touches upon commonly used digital tools and technologies and presents them in a way accessible to the non-expert. Through this study, it highlights the role of scholars in designing, implementing and using these tools.
description: Το βιβλίο αυτό αποτελεί εγχειρίδιο για τις ψηφιακές μεθόδους στις επιστήμες της παπυρολογίας και της παλαιογραφίας. Στοχεύει να παρουσιάσει τη διαδικασία της ψηφιοποίησης των αρχαίων κειμενικών τεκμηρίων, την διαχείριση των ψηφιοποιημένων χειρογράφων, τις νέες τεχνικές έρευνας που προσφέρουν οι σύγχρονες τεχνολογίες, καθώς και τις μεθόδους και δυνατότητες πρόσβασης στα τεκμήρια αυτά από τους ερευνητές και το ευρύτερο κοινό. Απευθύνεται σε αναγνώστες με σπουδές στις ανθρωπιστικές επιστήμες που δεν διαθέτει τεχνική κατάρτιση. Το εγχειρίδιο παρουσιάζει μια σφαιρική εικόνα της ψηφιακής παπυρολογίας και παλαιογραφίας. Εξετάζει ζητήματα συντήρησης, ψηφιοποίησης, διαχείρισης των ψηφιοποιημένων τεκμηρίων, μηχανικής ανάγνωσης και ανάλυσης γραφής, καθώς και των ηλεκτρονικών εκδόσεων. Παρουσιάζονται τα πιο ευρέως χρησιμοποιούμενα ψηφιακά εργαλεία και οι αντίστοιχες τεχνολογίες τους με τρόπο κατανοητό στους μη-ειδικούς. Παράλληλα, μέσα από την επισκόπηση αυτή, αναδεικνύεται ο ρόλος του φιλολόγου (ή άλλων ειδικών των ανθρωπιστικών επιστημών) στο σχεδιασμό και τη χρήση αυτών των εργαλείων.
Asymmetric synthesis of Heterocyclic Compounds through cascade Carbon-Carbon and Carbon-Heteroatom bond forming processes
Creators: name: Serusi, Lorenzo
Publisher: name: Universita degli studi di Salerno
Year: 2023
Subjects: subject: CHIM/06 CHIMICA ORGANICA

description: 2021 - 2022
description: The aim of my PhD thesis was focused on the asymmetric synthesis of new heterocyclic compounds using cascade and tandem processes involving the formation of new binding Carbon-Carbon and Carbon- Heteroatom. Heterocyclic structure are meaningful in organic synthesis for the role they hold in many fields such as pharmaceutical chemistry, polymers synthesis and vehicles in synthesis of other heterocyclic compounds. The project was focused on three mainly classes of heterocyclic compounds structurally related: Isoindolinones, Phtalides and Isoquinolones. These classes of molecules have been found in many naturally and synthetic compounds biologically active. The activity they show is strictly related to stereochemistry of asymmetric centers they host in their structure, about that the need of develop new synthetic routes to reach out them with high level of enantiopurity. In this project we design new starting materials with group enable to trigger important cascade reaction, under organocatalytic conditions, for easy access to important derivatives in high selectivity. Herein we reported the main three goals of this thesis: -Design of N-tosylbenzilidenimine (3.1) and α-amidosulphones (3.2) , derived by 2-formylbenzoates, for constructing γ-lactam ring of isoindolinone scaffold functionalized with sulphur group and nitromethyl side chain. -Synthesis of new imines derived by 2-formyl phenylacetate (3.5) for construction of 1-substituted isoquinolones through convenient solvent and catalyst free lactamization process. -Use of 2-cyanobenzaldehyde (3.4) and 2-formylbenzonitrile (3.3) in cascade reaction to access synthesis of phtalides and isoindolinones anologs of biologically active products bearing tetrasubstituted stereocenters. Through convenient design of structurally related starting materials, we achieved very satisfying results for synthesis of new class of heterocyclic compounds overcoming the limits of previous synthetic routes and giving new insights for exploring the synthetic power of these new starting materials. [edited by Author]
Comparative analysis of the role of Bacillus species as food fermenting and food spoilage organisms
Creators: Li,Zhen
Publisher: name: University of Alberta Library
Year: 2022

Bacillus species are fermenters in some food fermentation but spoilage organisms in other food products. For instance, bacilli and fungi are the predominant organisms in daqu fermentation. The antifungal lipopeptides produced by bacilli, including surfactins, fengycins and iturins, may impact fungal growth during daqu fermentation, thereby influencing the microbial community. The interaction between Bacillus lipopeptides and fungi in daqu is unclear. Therefore, a simulated model of daqu was created to investigate the role of antifungal lipopeptides in situ. The results showed that iturin A displayed the strongest antifungal activities in vitro. B. velezensis FUA2155 exhibit higher antifungal activity than two strains of B. amyloliquefaciens in the daqu model, due to the production of iturin A. Additionally, hydrolytic enzymes produced by Bacillus spp. can cause ropy bread spoilage, which leads to economic losses in bakeries. Bacillus spp. are wheat grain endophytes and form heat resistant endospores, consequently, process hygiene and heating during baking are insufficient to prevent ropy spoilage. Therefore, to reduce the negative impact of Bacillus and increase the shelf life of bread, sourdough was investigated as a biopreservative. The results indicated more than 2 d delay of spoilage with an addition of 12 % sourdough fermented by lactic acid bacteria. Bread with reutericyclin exhibited a bactericidal mode of action against strains of Bacillus.

In food industries, the high thermal loads that are required for inactivation of Bacillus spores can result in significant loss of food quality. Pressure-assisted thermal sterilization is a promising approach for spore inactivation without the need for high thermal stress. Nevertheless, the pressure resistance of Bacillus spores varies greatly. The spoVA2mob operon increases heat resistance of spores and multiple copies of the operon further increases the heat resistance. However, the role of spoVA2mob operon in pressure resistance is not well explored. In this study, the pressure resistance of 17 strains of Bacillus were correlated with the copy number of the spoVA2mob operon. To study the role of spoVA2mob operon in pressure resistance and spore germination triggered by different germinants, an isogenic mutant strain of Bacillus subtilis 168 with insertion of spoVA2mob operon was created. The spoVA2mob operon increased pressure resistance and decreased pressure induced spore germination significantly.

Overall, this research provides insights into the interaction of Bacillus and other microorganisms, such as fungi and lactic acid bacteria in food fermentations, to better understand the role of Bacillus as fermenting or food spoilage organisms.
Проблемы и перспективы технического и технологического переоснащения АПК Дальнего Востока
Creators: name: Чайка Анатолий Климентьевич
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: Сельское хозяйствоДальнего Востока в настоящее время развивается в соответствии с реализацией приоритетного национального проекта (ПНП) «Развитие АПК». На Дальнем Востоке производство продукции сельского хозяйства значительно отстает от среднего по России и эта тенденция все более усиливается. Минсельхозом подготовлен ряд мер, необходимых для реализации нацпроекта, в том числе Государственную программу развития сельского хозяйства и регулирования рынка сельскохозяйственной продукции, сырья и продовольствия на 2008-2012 гг.
Corrupting Neuron Explanations of Deep Visual Features
Creators: name: Srivastava, Divyansh
name: Oikarinen, Tuomas
name: Weng, Tsui-Wei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: The inability of DNNs to explain their black-box behavior has led to a recent surge of explainability methods. However, there are growing concerns that these explainability methods are not robust and trustworthy. In this work, we perform the first robustness analysis of Neuron Explanation Methods under a unified pipeline and show that these explanations can be significantly corrupted by random noises and well-designed perturbations added to their probing data. We find that even adding small random noise with a standard deviation of 0.02 can already change the assigned concepts of up to 28% neurons in the deeper layers. Furthermore, we devise a novel corruption algorithm and show that our algorithm can manipulate the explanation of more than 80% neurons by poisoning less than 10% of probing data. This raises the concern of trusting Neuron Explanation Methods in real-life safety and fairness critical applications.
Mycorrhizas and root traits of the riparian tree species Populus fremontii
Creators: Schaefer, Elena A.
Publisher: name: University of Alberta Library
Year: 2022

In hot and arid environments, trees may be particularly carbon-limited. In addition to supporting their own growth and activities, trees also lose carbon to associate with mycorrhizal fungi. Most trees form associations with either ecto- or arbuscular mycorrhizal fungi, and these fungi can have distinct effects on quantities of carbon released from fine roots and other root traits. Forests in arid regions are not uncommon, however trees in these areas must budget carbon as a limited resource, suggesting variation in carbon allocation to roots  and mycorrhizal fungi could be important for overall tree fitness. Populus fremontii occurs in the southwest United States, a region that has experienced more droughts with climate change. Increasing aridity throughout its range means P. fremontii’s future will be progressively more carbon-limited. Moreover, unlike most other plant species, this species simultaneously associates with both ecto- and  arbuscular mycorrhizal fungi, thus making it possible to decouple the effects of mycorrhizal type from tree species identity.

I tested the influence of mycorrhizal type on root traits, including fine root carbon flux, using provenances of P. fremontii known to vary in dominance of the two mycorrhizal types. In both a field study and greenhouse experiment, I confirmed not only that P. fremontii forms ecto- and arbuscular mycorrhizas simultaneously, but depending on provenance and environment, individuals also preferentially associate with one mycorrhizal type over the other. While I did not measure carbon allocation from P. fremontii to each mycorrhizal type, high colonization rates of both mycorrhizal types suggests carbon is transferred from trees to support these fungi. Mycorrhizal type, however, did not affect fine root carbon flux in either experiment, and overall, I measured extremely low fine root carbon-flux rates. In addition, root traits were variable and disconnected from mycorrhizal type, revealing highly context-dependent patterns. These results suggest that P. fremontii minimizes exudation of carbon across a range of environments, and the distinct effects of mycorrhizal type on root traits are nuanced. Compared with other tree species in wetter environments, P. fremontii is a conservative species in regard to fine root flux, with no indication that mycorrhizal fungi moderate this belowground process. As aridity increases in regions with historically wetter environments,  P. fremontii could signal how other tree species under increasing  carbon-limitation, might modify root traits including fine-root carbon flux and how this could influence belowground processes such as carbon cycling.
Кадровое обеспечение АПК Дальнего Востока в свете выполнения национального проекта «Развитие АПК»
Creators: name: Бумбар Иван Васильевич
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: Реализация приоритетного национального проекта «Развитие АПК» в значительной степени будет определяться качеством кадрового потенциала сельского хозяйства, что требует проведения постоянного мониторинга обеспечения квалифицированными кадрами. В последние годы Правительство РФ обратило серьезное внимание на закрепление кадров на селе как в производственной, так и социальной сфере. Появилась законодательная база врегионах, в том числеАмурской области.
OAHP Inventory, Building 2051 and 2052 Bath House, Fort Sam Houston, Texas
Creators: name: Office Of Archeology And Historic Preservation, Department Of The Interior
Publisher: name: Office of Archeology and Historic Preservation, Department of the Interior
Year: 1978
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Communal / Public Structure
valueUri: https://core.tdar.org/browse/site-type/314/communal-public-structure
subject: Historic Communal / Public Structure
valueUri: https://core.tdar.org/browse/site-type/316/historic-communal-public-structure
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Building 2052
valueUri: https://core.tdar.org/browse/other-keyword/146759/building-2052
subject: Building 2051
valueUri: https://core.tdar.org/browse/other-keyword/146758/building-2051
subject: Bath House
valueUri: https://core.tdar.org/browse/other-keyword/55993/bath-house
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An Office of Archaeology and Historic Preservation inventory form for Buildings 2051 and 2052 at Fort Sam Houston, Texas. The structures were built in 1929 and served as bath houses. The inventory gives a brief description of the buildings' construction, materials, and soundness.
Новые технологии в производстве сои
Creators: name: Тильба Владимир Арнольдович
Publisher: name: Дальневосточный аграрный вестник
Year: 2007

description: В статье рассматриваются проблемы технологического обновления отрасли соеводства, включая технические средства и технологию возделывания культуры. Как инновационный подход характеризуется стимуляция развития в посевах сои процессов симбиотической азотфиксации и возможности обновления технологии создания новых сортов.
Der RCDS - prinzipiell auf dem gleichen Boden wie die CDU; 1968
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Technischen Universität Berlin
Year: 2018

description: Enthält u. a.: Information über Ring Christlich Demokratischer Studenten (RCDS).- Presseerklärung vom 27. Juni 1968 (Abschrift).- Ich bin am RCDS interessiert (abtrennbares Formular).- Stempel des RCDS. 1 Seite. S/w.
Non-extensive Statistics and a Systematic Study of Meson-Spectra at LHC Energy $\sqrt{s_{NN}}=2.76$ TeV
Creators: name: De, Bhaskar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The transverse momentum spectra of secondary pions and kaons, produced in $P+P$ and various central $Pb+Pb$ collisions at $\sqrt{s_{NN}}=2.76$ TeV at LHC, have been analyzed systematically with an approach based on Tsallis non-extensive statistics. The analytical results have been utilized to determine some of the very important thermodynamical parameters bearing characteristic signatures of the partonic medium produced in such collisions.
description: 16 pages, 24 figures
Herzlichen Glückwunsch. Die GoN; 1968
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Technischen Universität Berlin
Year: 2018

description: Enthält u. a.: Darstellung des Mißtrauensantrags vom 9. Mai 1968, der Abwahl des Vorstand der Studentenvertretung am 9. Mai 1968 sowie des Verlaufs der folgenden Neuwahl am 17. Mai 1968 durch den Hochschulpolitischen Ausschuß der Berliner Burschenschaften. Handschriftliche Formeln mit Skizze ohne inhaltlichen Zusammenhang (Rückseite). 1 Seite. S/w.
Minimal Massive Gravity: Conserved Charges, Excitations and the Chiral Gravity Limit
Creators: name: Tekin, Bayram
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We find the excitations and construct the conserved charges ( mass and angular momentum) of the recently found Minimal Massive Gravity (MMG) in 2+1 dimensions in asymptotically Anti-de Sitter (AdS) spacetimes. The field equation of the theory does not come from an action and hence lacks the required Bianchi Identity needed to define conserved charges. But the theory, which also provides a healthy extension of the Topologically Massive Gravity in the bulk and boundary of spacetime, does admit conserved charges for metric that are solutions. Our construction is based on background Killing vectors and imperative to provide physical meaning to the integration constants in the black hole type metrics. We also study the chiral gravity limit of MMG.
description: 9 pages, reference added, typos corrected