cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer
Creators: name: Peacock, J.
name: Routh, E. D.
name: Yeh, J. J.
name: Sandler, R. S.
name: Keku, T. O.
name: Shen, X. J.
name: Kim, H. J.
name: Martin, T. D.
name: Der, C. J.
name: Rubinas, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Phase II clinical trials of MEK inhibitors are ongoing and ERK1/2 activation is frequently used as a biomarker. In light of the mutational activation of BRAF and KRAS in colorectal cancer (CRC), inhibitors of the Raf-MEK-ERK mitogen-activated protein kinase are anticipated to be promising. Previous studies in pancreatic cancer have found little correlation between BRAF/KRAS mutation status and ERK1/2 activation, suggesting that identifying biomarkers of MEK inhibitor response may be more challenging than previously thought. The purpose of this study was to evaluate the effectiveness of MEK inhibitor therapy for CRC and BRAF/KRAS mutation status and ERK1/2 activation as biomarkers for MEK inhibitor therapy. First, we found that MEK inhibitor treatment impaired the anchorage-independent growth of nearly all KRAS/BRAF mutant, but not wild-type, CRC cells. There was a correlation between BRAF, but not KRAS, mutation status and ERK1/2 activation. Second, neither elevated ERK1/2 activation nor reduction of ERK1/2 activity correlated with MEK inhibition of anchorage-independent growth. Finally, we validated our cell line observations and found that ERK1/2 activation correlated with BRAF, but not KRAS, mutation status in 190 patient CRC tissues. Surprisingly, we also found that ERK activation was elevated in normal colonic epithelium, suggesting that normal cell toxicity may be a complication for CRC treatment. Our results suggest that although MEK inhibitors show promise in CRC, KRAS/BRAF mutation status, but not ERK activation as previously thought, may be useful biomarkers for MEK inhibitor sensitivity.
Breakup of three particles within the adiabatic expansion method
Creators: name: Garrido, E.
name: Kievsky, A.
name: Viviani, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: General expressions for the breakup cross sections in the lab frame for $1+2$ reactions are given in terms of the hyperspherical adiabatic basis. The three-body wave function is expanded in this basis and the corresponding hyperradial functions are obtained by solving a set of second order differential equations. The ${\cal S}$-matrix is computed by using two recently derived integral relations. Even though the method is shown to be well suited to describe $1+2$ processes, there are nevertheless particular configurations in the breakup channel (for example those in which two particles move away close to each other in a relative zero-energy state) that need a huge number of basis states. This pathology manifests itself in the extremely slow convergence of the breakup amplitude in terms of the hyperspherical harmonic basis used to construct the adiabatic channels. To overcome this difficulty the breakup amplitude is extracted from an integral relation as well. For the sake of illustration, we consider neutron-deuteron scattering. The results are compared to the available benchmark calculations.
Supplementary document for Soliton-pair dynamical transition in mode-locked lasers - 6067834.pdf
Creators: name: Sulimany, Kfir
name: Tziperman, Offek
name: Bromberg, Yaron
name: Gat, Omri
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplementary information
Platinum neurotoxicity pharmacogenetics
Creators: name: Goldberg, R. M.
name: McWhinney, S. R.
name: McLeod, H. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cisplatin, carboplatin, and oxaliplatin anticancer drugs are commonly used to treat lung, colorectal, ovarian, breast, head/neck, and genitourinary cancers. However, the efficacy of platinum-based drugs is often compromised because of the substantial risk for severe toxicities, including neurotoxicity. Neurotoxicity can result in both acute and chronic debilitation. Moreover, colorectal cancer patients treated with oxaliplatin more often discontinue therapy due to peripheral neuropathy than for tumor progression, potentially compromising patient benefit. Numerous methods to prevent neurotoxicity have so far proven unsuccessful. In order to circumvent this life-altering side effect, while taking advantage of the antitumor activities of the platinum agents, efforts to identify mechanism-based biomarkers are underway. In this review, we detail findings from the current literature for genetic markers associated with neurotoxicity induced by single agent and combination platinum chemotherapy. These data have the potential for broad clinical implications if mechanistic associations lead to the development of toxicity modulators to minimize the noxious sequelae of platinum chemotherapy.
What sources of organic carbon drive food webs in billabongs? A study based on stable isotope analysis
Creators: name: Bunn, Stuart E
name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

We used the stable isotopes of carbon and nitrogen to examine the food webs of three small flood-plain lakes (billabongs) in south-eastern Australia. With few exceptions, stable carbon isotope analysis could not be used to discriminate among the conspicuous potential sources of fringing, emergent or floating vegetation or benthic detritus. These primary sources showed little spatial or temporal variation in 13C values, with means ranging from-28.5 to-26.8 in spring and-29.1 to-25.4 in late summer. Submerged vegetation had similar 13C values to the above sources in spring but showed greater spatial variation and were less 13C-depleted, considerably so in some species, in late summer. Epiphytes and algae were 13C-depleted in spring compared with the other primary sources but became more 13C-enriched in late summer. Mean 13C values for primary and secondary consumers were not only far more variable (-37.4 to-22.7) but in general were more negative than the potential food sources, particularly in spring. Using the combined information from stable carbon and nitrogen isotope analysis, we could narrow down the list of potential primary sources driving food webs in these billabongs. The freshwater crayfish (Cherax) was one of the few taxa that appeared to obtain its biomass carbon from detrital material. Gastropods and leptocerid caddis larvae on emergent or submerged vegetation obtained a mixture of carbon from epiphytes and macrophytes; in both taxa, epiphytes contributed more to biomass carbon than did the macrophytes. However, other common grazers and collector/gatherers sampled from macrophytes, e.g. baetid mayflies, chironomid larvae and atyid shrimps, were often too 13C-depleted even to have derived their biomass carbon solely from epiphytes. Many other primary consumers, including zooplankton, and mussels (Velesunio), and most of the secondary consumers, including water mites (Hydracarina), phantom midge larvae (Chaoborus) and fish, were also 13C-depleted. The enormous biomass of littoral and fringing vegetation could contribute to metazoan food webs in these billabongs only if an additional highly 13C-depleted source was consumed simultaneously. Methane released from billabong sediments could provide such a 13C-depleted carbon source that is re-introduced into metazoan food webs via the consumption of methanotrophic bacteria. Alternatively, food webs in these water bodies are largely driven by an unknown and inconspicuous 13C-depleted primary producer, such as planktonic Chlorophyta.
Rechnungsbüchlein zum Sammlungsbau für das Amerbachkabinett
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1578

description: Baukosten
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Druck: Das Rechnungsbüchlein zum Sammlungsbau / hrsg. von Elisabeth Landolt, in: Beiträge zu Basilius Amerbach (=Sammeln in der Renaissance. Das Amerbach-Kabinett ; Bd. 5). - Basel : Öffentliche Kunstsammlung Basel, 1991. - S. 239-274
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
MPEC 2024-R360 : 2024 RF32
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RF32

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Galaxy Zoo: Kinematics of strongly and weakly barred galaxies
Creators: name: Géron, Tobias
name: Smethurst, Rebecca J.
name: Lintott, Chris
name: Kruk, Sandor
name: Masters, Karen L.
name: Simmons, Brooke
name: Mantha, Kameswara Bharadwaj
name: Walmsley, Mike
name: Garma-Oehmichen, L.
name: Drory, Niv
name: Lane, Richard R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the bar pattern speeds and corotation radii of 225 barred galaxies, using IFU data from MaNGA and the Tremaine-Weinberg method. Our sample, which is divided between strongly and weakly barred galaxies identified via Galaxy Zoo, is the largest that this method has been applied to. We find lower pattern speeds for strongly barred galaxies than for weakly barred galaxies. As simulations show that the pattern speed decreases as the bar exchanges angular momentum with its host, these results suggest that strong bars are more evolved than weak bars. Interestingly, the corotation radius is not different between weakly and strongly barred galaxies, despite being proportional to bar length. We also find that the corotation radius is significantly different between quenching and star forming galaxies. Additionally, we find that strongly barred galaxies have significantly lower values for R, the ratio between the corotation radius and the bar radius, than weakly barred galaxies, despite a big overlap in both distributions. This ratio classifies bars into ultrafast bars (R < 1.0; 11% of our sample), fast bars (1.0 < R < 1.4; 27%) and slow bars (R > 1.4; 62%). Simulations show that R is correlated with the bar formation mechanism, so our results suggest that strong bars are more likely to be formed by different mechanisms than weak bars. Finally, we find a lower fraction of ultrafast bars than most other studies, which decreases the recently claimed tension with ΛCDM. However, the median value of R is still lower than what is predicted by simulations.
description: 20 pages, 16 figures
Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines
Creators: name: Watson, V. G.
name: Motsinger-Reif, A.
name: Harris, T.
name: Hardison, N. E.
name: McLeod, H. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We have attempted to use a familial genetics strategy to study mechanisms of Topoisomerase 1 (Top1) inhibition. Investigations have steadily been chipping away at the pathways involved in cellular response following Top1 inhibition for more than 20 years. Our system-wide approach, which phenotypes a collection of genotyped human cell lines for sensitivity to compounds, interrogates all genes and molecular pathways simultaneously. Previously, we characterized the in vitro sensitivity of fifteen families of CEPH cell lines (n = 142) to nine camptothecin analogues. Linkage analysis revealed a pattern of seven quantitative trait loci (QTLs) shared by all of the camptothecins. To identify which, if any, QTLs are related to the general mechanism of Top1 inhibition or should be considered camptothecin-specific, we characterized the in vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top 1 inhibitors. Four QTLs on chromosomes 1, 5, 11, and 16 were shared by both the camptothecins and the indenoisoquinolines and are considered associated with the general mechanism of Top1 inhibition. The remaining three QTLs (chromosomes 6 and 20) are considered specific to camptothecin-induced cytotoxicity. Finally, eight QTLs were identified which were unique to the indenoisoquinolines.
Rektoratsrechnung vom Juni 1580 bis Juni 1581
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1580

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
A Grammar for the national English curriculum traditional, functional, structural, or what?
Creators: name: Bernard, Nan
Publisher: name: La Trobe
Year: 2023

description: This paper explores some possible approaches to grammar teaching and its role in the study of language as prescribed by the framework of the National English Curriculum (NEC). This framework provides a common base from which state education systems and schools can develop a curriculum along national guidelines, for years 1 to 12. At the time of writing, the frameworks for each area of learning, including English, were still under consideration for incorporation into state curriculums. The paper divides belt into six sections. Section 1 outlines the topic and scope of the paper; section 2 sets the background and provides some general criteria for evaluating the grammars under consideration; sections 3, 4, 5 respectively, examine three approaches to grammar, traditional, functional and structural; section 6 discusses the findings and suggests directions which may best serve students’ interests.
Solvable Dynamics of Coupled High-Dimensional Generalized Limit-Cycle Oscillators
Creators: name: Zou, Wei
name: He, Sujuan
name: Senthilkumar, D. V.
name: Kurths, Juergen
Publisher: name: arXiv
Year: 2023
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: We introduce a new model consisting of globally coupled high-dimensional generalized limit-cycle oscillators, which explicitly incorporates the role of amplitude dynamics of individual units in the collective dynamics. In the limit of weak coupling, our model reduces to the $D$-dimensional Kuramoto phase model, akin to a similar classic construction of the well-known Kuramoto phase model from weakly coupled two-dimensional limit-cycle oscillators. For the practically important case of $D=3$, the incoherence of the model is rigorously proved to be stable for negative coupling $(K<0)$ but unstable for positive coupling $(K>0)$; the locked states are shown to exist if $K>0$; in particular, the onset of amplitude death is theoretically predicted. For $D\geq2$, the discrete and continuous spectra for both locked states and amplitude death are governed by two general formulas. Our proposed $D$-dimensional model is physically more reasonable, because it is no longer constrained by fixed amplitude dynamics, which puts the recent studies of the $D$-dimensional Kuramoto phase model on a stronger footing by providing a more general framework for $D$-dimensional limit-cycle oscillators.
description: Accepted for Publication in Physical Review Letters
Nanothermal Characterization of Amorphous and Crystalline Phases in Chalcogenide Thin Films with Scanning Thermal Microscopy
Creators: name: Bosse, J. L.
name: Timofeeva, M.
name: Tovee, P. D.
name: Robinson, B. J.
name: Huey, B. D.
name: Kolosov, O. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The thermal properties of amorphous and crystalline phases in chalcogenide phase change materials (PCM) play a key role in device performance for non-volatile random-access memory. Here, we report the nanothermal morphology of amorphous and crystalline phases in laser pulsed GeTe and Ge2Sb2Te5 thin films by scanning thermal microscopy (SThM). By performing SThM measurements and applying quantitative physical models to two film thicknesses, the PCM thermal conductivities and thermal boundary conductances between the PCM and SThM probe are independently estimated for the amorphous and crystalline phase of each stoichiometry.
title: Ọ̀rúnmìliàn Film-Philosophy : An African Philosophy through Cinematic Storytelling
Creators: name: Bello, Saheed Adesumbo
name: Bayreuth Academy Of Advanced African Studies
Publisher: name: University of Bayreuth
Year: 2023
Subjects: subject: Africa
subject: Film
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Storytelling
subject: Ọ̀rúnmìlà
subject: Yorùbá
subject: 100
subject: 700

description: This paper develops a film-philosophy, (which I call “Ọ̀rúnmìliàn film-philosophy”), by exploring and analyzing the praxis of Ọ̀rúnmìlà oral philosophy and narrative aesthetics in an African cinematic storytelling. It defends a modest thesis by using Saworoide (dir. Túndé Kèlání’s, 1999) as an example of how the African/Nigerian filmmakers are influenced by their inherited oral philosophical traditions. It argues that the condition of philosophy that gives “presence to non-presence” (so that the living can dialogue with the dead) and “knowledge to the unknown” (in order to heal and to re-moralize the living) is central to the Ọ̀rúnmìliàn film-philosophy. The central argument is based on what I call the Ọ̀rúnmìlà “parable of Eégún” (masquerade); and the film-philosophy finds some philosophical similarities in Stanley Cavell’s The World Viewed on the one hand, and Christopher Falzon’s concept of cinema as philosophy, (which is based on Plato’s parable of the cave), on the other. The paper therefore stresses the intercultural correlation between an African film-Philosophy and the modern European/western traditions of film-philosophy. It contributes to film and philosophy scholarship by exploring the manifestations of Yorùbá/Ọ̀rúnmìlà philosophical texts in the contemporary Nigerian film as case study of how contemporary African filmmakers, like their oral artiste counterparts, continue to articulate their inherited traditions via cinematic storytelling.
Rektoratsrechnung vom Juni 1586 bis Juni 1587
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1586

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation
Creators: name: Coleman, W. B.
name: Fricano, C. J.
name: Timmerman, L. A.
name: Wells, W. A.
name: Chaychi, L.
name: Memoli, V. A.
name: Flanagan, A. J.
name: Kuemmerle, N. B.
name: Kinlaw, W. B.
name: Morganelli, P. M.
name: Rysman, E.
name: Swinnen, J. V.
name: Froehlich, H. M.
name: Eisenberg, B. L.
name: Lombardo, P. S.
name: Pettus, J. R.
name: Lipe, B. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Many types of cancer cells require a supply of fatty acids (FA) for growth and survival, and interrupting de novo FA synthesis in model systems causes potent anticancer effects. We hypothesized that, in addition to synthesis, cancer cells may obtain pre-formed, diet-derived fatty acids by uptake from the bloodstream. This would require hydrolytic release of FA from triglyceride in circulating lipoprotein particles by the secreted enzyme lipoprotein lipase (LPL), and the expression of CD36, the channel for cellular FA uptake. We find that selected breast cancer and sarcoma cells express and secrete active LPL, and all express CD36. We further demonstrate that LPL, in the presence of triglyceride-rich lipoproteins, accelerates the growth of these cells. Providing LPL to prostate cancer cells, which express low levels of the enzyme, did not augment growth, but did prevent the cytotoxic effect of FA synthesis inhibition. Moreover, LPL knockdown inhibited HeLa cell growth. In contrast to the cell lines, immunohistochemical analysis confirmed the presence of LPL and CD36 in the majority of breast, liposarcoma, and prostate tumor tissues examined (n = 181). These findings suggest that, in addition to de novo lipogenesis, cancer cells can use LPL and CD36 to acquire FA from the circulation by lipolysis, and this can fuel their growth. Interfering with dietary fat intake, lipolysis, and/or fatty acid uptake will be necessary to target the requirement of cancer cells for FA.
title: La pandémie de Covid-­19 a­-t­-elle créé de la pauvreté en France ? (LIEPP Policy Brief, n°65)
Creators: name: Bouchet, Célia
name: Duvoux, Nicolas
Publisher: name: Sciences Po - LIEPP
Year: 2023
Subjects: classificationCode: 5
subject: FOS: Social sciences

description: L’Institut national de la statistique et des études économiques mesure un taux de pauvreté monétaire stable entre 2019 et 2020, alors que plusieurs contributions scientifiques et associatives relèvent d'importantes difficultés socio­économiques au sein de certains groupes durant la pandémie de Covid­19. À l’aide d’une analyse secondaire de neuf enquêtes quantitatives et qualitatives récoltées par le Conseil national des politiques de lutte contre la pauvreté et l’exclusion sociale (CNLE) en 2021, nous montrons que plusieurs groupes sociaux ont été exposés à des fragilisations diverses dans leur format, leur chronologie et leurs mécanismes. Nous en développons des implications concernant les mesures de la pauvreté, les inégalités de protection sociale, les solidarités non­étatiques et les temporalités des politiques de pauvreté.
A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth
Creators: name: Ketelsen, D.
name: Patterson, C.
name: Snyder, S.
name: Ma, P.
name: Rossi, E.
name: Siamakpour-Reihani, S.
name: Hilliard, E.
name: Bone, B.
name: Mumper, R.
name: Fontenot, E.
name: Santos, C.
name: Klauber-DeMore, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Secreted frizzled related protein 2 (SFRP2) is overexpressed in human angiosarcoma and breast cancer, and stimulates angiogenesis via activation of the calcineurin/ NFATc3 pathway. There are conflicting reports in the literature as to whether SFRP2 is an antagonist or agonist of ß-catenin. The aims of these studies were to assess the effects of SFRP2 antagonism on tumor growth and Wnt-signaling, and to evaluate whether SFRP2 is a viable therapeutic target. The anti-angiogenic and anti-tumor properties of SFRP2 monoclonal antibody (mAb) were assessed using in vitro proliferation, migration, and tube formation assays; and in vivo angiosarcoma and triple negative breast cancer models. Wnt-signaling was assessed in endothelial and tumor cells treated with SFRP2 mAb using Western blotting. Pharmacokinetic (PK) and biodistribution data were generated in tumor-bearing and non-tumor bearing mice. SFRP2 mAb was shown to induce anti-tumor and anti-angiogenic effects in vitro, and inhibit activation of ß-catenin and NFATc3 in endothelial and tumor cells. Treatment of SVR angiosarcoma allografts in nude mice with the SFRP2 mAb decreased tumor volume by 58% compared to control (p=0.004). Treatment of MDA-MB-231 breast carcinoma xenografts with SFRP2 mAb decreased tumor volume by 52% (p=0.03) compared to control, while bevacizumab did not significantly reduce tumor volume. Pharmacokinetic studies show the antibody is long circulating in the blood and preferentially accumulates in SFRP2-positive tumors. In conclusion, antagonizing SFRP2 inhibits activation of ß-catenin and NFATc3 in endothelial and tumor cells, and is a novel therapeutic approach to inhibiting angiosarcoma and triple negative breast cancer.
Haushaltsbuch
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1561

description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Druck: Aus der Werkstatt der Amerbach-Edition / Ueli Dill, Beat Rudolf Jenny. - Basel : Schwabe, 2000. - S. 333-425
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Fermi-LAT Detection of Pulsed Gamma-rays Above 50 GeV from the Vela Pulsar
Creators: name: Leung, Gene C. K.
name: Takata, J.
name: Ng, C. W.
name: Kong, A. K. H
name: Tam, P. H. T.
name: Hui, C. Y.
name: Cheng, K. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The First \fermi-LAT Catalog of Sources Above 10 GeV reported evidence of pulsed emission above 25 GeV from 12 pulsars, including the Vela pulsar, which showed evidence of pulsation at $>37$ GeV energy bands. Using 62 months of \fermi-LAT data, we analyzed the gamma-ray emission from the Vela pulsar and searched for pulsed emission above 50 GeV. Having confirmed the significance of the pulsation in 30-50 GeV with the H-test (p-value $\sim10^{-77}$), we extracted its pulse profile using the Bayesian block algorithm and compared it with the distribution of the 5 observed photons above 50 GeV using the likelihood ratio test. Pulsation was significantly detected for photons above 50 GeV with p-value $=3\times10^{-5}$ ($4.2σ$). The detection of pulsation is significant above $4σ$ at $>79$ GeV and above $3σ$ at $>90$ GeV energy bands, making this the highest energy pulsation significantly detected by the LAT. We explore non-stationary outer gap scenario of the very high-energy emissions from the Vela pulsar.
description: 14 pages, 4figures, accepted by ApJ Letter
A survey of registration practices among observational researchers using preexisting datasets
Creators: name: Thibault, Robert
name: Hardwicke, Tom
name: Sarafoglou, Alexandra
name: Ioannidis, John
name: Munafo, Marcus
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: blind data analysis
subject: hold-out sample
subject: longitudinal dataset
subject: meta-research
subject: preregistration
subject: survey

description: This survey seeks to gather data on (1) the opinions and practices of observational researchers regarding rigour and reproducibility, and (2) their thoughts on the use of hold-out samples for analyzing preexisting datasets. We will use this data to refine a potential intervention aimed to improve research quality and to determine whether observational researchers find such an intervention acceptable. The study protocol is available in the file "ECAW_protocol_220923.docx".
Light scattering by radiation fields: the optical medium analogy
Creators: name: Bini, Donato
name: Fortini, Pierluigi
name: Geralico, Andrea
name: Haney, Maria
name: Ortolan, Antonello
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The optical medium analogy of a radiation field generated by either an exact gravitational plane wave or an exact electromagnetic wave in the framework of general relativity is developed. The equivalent medium of the associated background field is inhomogeneous and anisotropic in the former case, whereas it is inhomogeneous but isotropic in the latter. The features of light scattering are investigated by assuming the interaction region to be sandwiched between two flat spacetime regions, where light rays propagate along straight lines. Standard tools of ordinary wave optics are used to study the deflection of photon paths due to the interaction with the radiation fields, allowing for a comparison between the optical properties of the equivalent media associated with the different background fields.
description: 6 pages, 4 figures; published version
Dekanatsrechnung vom Juni 1585 bis Juni 1586
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1585

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Asymmetries of AGN jets in inhomogeneous media
Creators: name: Gaibler, Volker
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Considerable asymmetries in jets from active galactic nuclei (AGN) and associated double radio sources can be caused by an inhomogeneous interstellar medium of the host galaxy. These asymmetries can easily be estimated by 1D propagation models, but hydrodynamical simulations have shown that the actual asymmetries can be considerably larger. With a set of smaller-scale hydrodynamical simulations we examine these asymmetries, and find they are typically a factor of $\sim 3$ larger than in 1D models. We conclude that, at high redshift, large asymmetries in radio sources are expected in gas-rich galaxies with a clumpy interstellar medium.
description: 6 pages, 2 figures, published in the proceedings of the 4th High Energy Phenomena in Relativistic Outflows (HEPRO IV) meeting 2013
Rektoratsrechnung vom Juni 1566 bis Juni 1567
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1566

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Haushaltsbuch
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1569

description: Basilius Amerbach
description: Blätter 25a-25d sind leer.
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Aus der Werkstatt der Amerbach-Edition / Ueli Dill, Beat Rudolf Jenny. - Basel : Schwabe, 2000. - S. 333-425
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Airspace structure and mathematical modelling of oxygen diffusion, aeration and anoxia in Eleocharis sphacelata R. Br. Roots
Creators: name: Sorrell, Brian K
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

A quantitative description of the structure of the roots of Eleocharis sphacelata is presented, forming the basis of a mathematical analysis of their aeration via the intercellular airspace system. The mature aerenchymatous roots have cortical porosites as high as 70% and resistances to axial diffusion of 0.015-0.04 Ms mm-3 per mm root length. The corresponding resistance in the younger, non-aerenchymatous tissue just behind the apex is 0.08-0.14 Ms mm-3 per mm, root length. The observed maximum length of the roots (about 0.3 m) is not caused by the oxygen limitations at the apical meristem of the main axis because axial fluxes could theoretically support the meristem in much longer roots. However, the phloem and pericycle of the stele become hypoxic at 0.25 to 0.3 m, suggesting that length could be limited by the need to prevent excessive hypoxia in these tissues. Rates of root oxygen release into the sediment are predicted to be as high as 2.5 µmol h-1 per 0.3-m-long root and higher still for shorter roots. The prevention of anoxia depends greatly on the basal oxygen concentration at the root base: oxygen partial pressures below 8 kPa in the rhizome would cause meristematic anoxia in 0.3 m-long roots. A better resolution of fine-scale variations in respiratory activity in the roots and in the sediment rhizosphere could improve the accuracy of the model, but it does nevertheless indicate that roots of E. sphacelata would normally remain aerobic and significantly oxidize anaerobic sediments in situ.
Aufstellung von Reisekosten auf der Route von Padua nach Augsburg
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1555

description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
Creators: name: Janzen, William P.
name: Christoph, Sandra
name: Kireev, Dmitri
name: Hull-Ryde, Emily A.
name: Yang, Chao
name: DeRyckere, Deborah
name: Wang, Xiaodong
name: Simpson, Catherine
name: Cummings, Christopher T.
name: Trakhimets, Alesia Y.
name: Johnson, Gary L.
name: Hunter, Debra M.
name: Earp, H. Shelton
name: Liu, Jing
name: Batchelor, Lance A.
name: Schlegel, Jennifer
name: Frye, Stephen V.
name: Norris-Drouin, Jacqueline
name: Frazer, J. Kimble
name: Graham, Douglas K.
name: Sather, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although survival rates have improved, patients with certain biological subtypes still have suboptimal outcomes. Current chemotherapeutic regimens are associated with short- and long-term toxicities and novel, less toxic therapeutic strategies are needed. Mer receptor tyrosine kinase is ectopically expressed in ALL patient samples and cell lines. Inhibition of Mer expression reduces pro-survival signaling, increases chemosensitivity, and delays development of leukaemia in vivo suggesting that Mer tyrosine kinase inhibitors are excellent candidates for targeted therapies. Brain and spinal tumors are the second most common malignancies in childhood. Multiple chemotherapy approaches and radiation have been attempted, yet overall survival remains dismal. Mer is also abnormally expressed in atypical teratoid/rhabdoid tumors (ATRT), providing a rationale for targeting Mer as a therapeutic strategy. We have previously described UNC569, the first small molecule Mer inhibitor. This manuscript describes the biochemical and biological effects of UNC569 in ALL and ATRT. UNC569 inhibited Mer activation and downstream signaling through ERK1/2 and AKT, determined by western blot analysis. Treatment with UNC569 reduced proliferation/survival in liquid culture, decreased colony formation in methylcellulose/soft agar, and increased sensitivity to cytotoxic chemotherapies. MYC transgenic zebrafish with T-ALL were treated with UNC569 (4 µM for 2 weeks). Fluorescence was quantified as indicator of the distribution of lymphoblasts, which express Mer and enhanced green fluorescent protein. UNC569 induced >50% reduction in tumor burden compared to vehicle- and mock-treated fish. These data support further development of Mer inhibitors as effective therapies in ALL and ATRT.
Competitive exclusion in Cladocera through elevated mortality of adults
Creators: name: Matveev, Vladimir
name: Gabriel, Wilfried
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The population dynamics of two cladocerans, Ceriodaphnia pulchella and Diaphanosoma brachyurum competing under laboratory conditions in lake water was analysed using cross-correlations. Both mixed and isolated populations of the two cladocerans showed delayed density-dependence in the death rates of juveniles and adults as well as in fecundity rate. The regressions for each of the three rates on total density of competitors were compared between the two species. There were no significant differences in the slopes of regressions for fecundity rates and the death rates of juveniles. However, in the inferior competitor (Diaphanosoma) which went extinct in all treatments, the death rate of adults increased with total density much more quickly than in the superior competitor (Ceriodaphnia). The intraspecific comparisons indicated that while Ceriodaphnia adults survived better than juveniles under conditions of crowding, in Diaphanosoma, juveniles were better survivors than adults. These data suggest that the contention of higher vulnerability of cladoceran juveniles than adults to starvation and crowding may prove to be not a universal phenomenon.
Dark energy from cosmological fluids obeying a Shan-Chen non-ideal equation of state
Creators: name: Bini, Donato
name: Geralico, Andrea
name: Gregoris, Daniele
name: Succi, Sauro
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider a Friedmann-Robertson-Walker universe with a fluid source obeying a non-ideal equation of state with "asymptotic freedom," namely ideal gas behavior (pressure changes directly proportional to density changes) both at low and high density regimes, following a fluid dynamical model due to Shan and Chen. It is shown that, starting from an ordinary energy density component, such fluids naturally evolve towards a universe with a substantial "dark energy" component at the present time, with no need of invoking any cosmological constant. Moreover, we introduce a quantitative indicator of darkness abundance, which provides a consistent picture of the actual matter-energy content of the universe.
description: 12 pages, 9 figures; published version
KMT-2021-BLG-1122L: The first microlensing triple stellar system
Creators: name: Han, Cheongho
name: Jung, Youn Kil
name: Gould, Andrew
name: Kim, Doeon
name: Lee, Chung-Uk
name: Albrow, Michael D.
name: Chung, Sun-Ju
name: Hwang, Kyu-Ha
name: Kim, Hyoun-Woo
name: Ryu, Yoon-Hyun
name: Shin, In-Gu
name: Shvartzvald, Yossi
name: Yang, Hongjing
name: Yee, Jennifer C.
name: Zang, Weicheng
name: Cha, Sang-Mok
name: Kim, Dong-Jin
name: Kim, Seung-Lee
name: Lee, Dong-Joo
name: Lee, Yongseok
name: Park, Byeong-Gon
name: Pogge, Richard W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We systematically inspect the microlensing data acquired by the KMTNet survey during the previous seasons in order to find anomalous lensing events for which the anomalies in the lensing light curves cannot be explained by the usual binary-lens or binary-source interpretations. From the inspection, we find that interpreting the three lensing events OGLE-2018-BLG-0584, KMT-2018-BLG-2119, and KMT-2021-BLG-1122 requires four-body (lens+source) models, in which either both the lens and source are binaries (2L2S event) or the lens is a triple system (3L1S event). Following the analyses of the 2L2S events presented in \citet{Han2023}, here we present the 3L1S analysis of the KMT-2021-BLG-1122. It is found that the lens of the event KMT-2021-BLG-1122 is composed of three masses, in which the projected separations (normalized to the angular Einstein radius) and mass ratios between the lens companions and the primary are $(s_2, q_2)\sim (1.4, 0.53)$ and $(s_3, q_3) \sim (1.6, 0.24)$. By conducting a Bayesian analysis, we estimate that the masses of the individual lens components are $(M_1, M_2, M_3)\sim (0.47\,M_\odot, 0.24\,M_\odot, 0.11\,M_\odot)$. The companions are separated in projection from the primary by $(a_{\perp,2}, a_{\perp,3})\sim (3.5, 4.0)$~AU. The lens of KMT-2018-BLG-2119 is the first triple stellar system detected via microlensing.
description: 8 pages, 7 figures, 2 tables
Rektoratsrechnung vom Juni 1587 bis Juni 1588
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1587

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer
Creators: name: Mangala, S. L.
name: Armaiz-Pena, G. N.
name: Lopez-Berestein, G.
name: Gharpure, K. M.
name: Rupaimoole, R.
name: Luft, J. C.
name: Wu, S. Y.
name: Chu, K. S.
name: Bowerman, C. J.
name: Rahhal, T. B.
name: DeSimone, J. M.
name: Pradeep, S.
name: Han, H.-D.
name: Napier, M. E.
name: Miyake, T.
name: Sood, A. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and anti-angiogenic mEZH2 siRNA incorporated into chitosan nanoparticles. In vivo dose-finding studies and therapeutic experiments were conducted in well-established orthotopic mouse models of epithelial ovarian cancer. Antitumor effects were determined on the basis of reduction in mean tumor weight and number of metastatic tumor nodules in the animals. The tumor tissues from these in vivo studies were stained to evaluate the proliferation index (Ki67), apoptosis index (cleaved caspase 3), and microvessel density (CD31). The lowest dose of metronomic regimen (0.5 mg/kg) resulted in significant reduction in tumor growth. The combination of PLGA-PRINT-docetaxel and CH-mEZH2 siRNA showed significant antitumor effects in the HeyA8 and SKOV3ip1 tumor models (p<0.05). Individual as well as combination therapies showed significant anti-angiogenic, anti-proliferative, and pro-apoptotic effects, and combination therapy had additive effects. Metronomic delivery of PLGA-PRINT-docetaxel combined with CH-mEZH2 siRNA has significant antitumor activity in preclinical models of ovarian cancer.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: L’articolo presenta tre cartoline postali inedite di Cesare Pavese inviate ad Augusto Monti durante gli anni Quaranta. Nelle lettere Pavese discute il successo di critica di “Paesi tuoi” e risponde al giudizio entusiastico di Monti su “La Spiaggia”. Queste lettere ci aiutano a capire ancora meglio il legame tra Pavese e Monti.
description: The paper submits three Cesare Pavese’s unpublished postcards sent to Augusto Monti during the forties. In the letters Pavese discusses the critical success of “Paesi tuoi” and responds to Monti’s enthusiastic opinion about “La Spiaggia”. These letters help us understand better how Pavese and Monti are connected.
The evolution of single B-type stars with a large angular momentum content
Creators: name: Granada, Anahí
name: Haemmerlé, Lionel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The database of intermediate mass rotating stellar models presented in the past years by the Geneva Stellar Evolution Group can be used to build synthetic stellar populations that fully account for the effects of stellar rotation. However, up to now we still lacked stellar evolutionary tracks that rotate close to the critical limit during the whole MS phase. This occurs because the flat internal profile of rotation imposed at the Zero-Age MS (ZAMS) is modified by the action of meridional currents immediately after the ZAMS, causing the surface rotational velocity to decrease abruptly until it reaches a quasi-stationary state. We compute stellar models with non-solid rotation at the ZAMS to obtain stellar evolutionary tracks with a larger content of angular momentum, that attain rotational equatorial velocities close to the critical limit throughout their MS phase. These models have a longer MS lifetime and a higher surface chemical enrichment already at the end of the MS, particularly at Z=0.002. Stellar models with solid rotation at the ZAMS adequately represent the overall characteristics and evolution of differentially rotating models of identical angular momentum content, but with a lower initial surface rotational velocity. For these models we recommend to use as the initial rotational rate the values derived once the quasi-stationary state is reached, after the abrupt decrease in surface velocity. Interestingly, the initial equatorial rotational velocities are virtually metallicity independent for the stellar models we computed with the same mass and angular momentum content at the ZAMS. If, as some observational evidence indicates, B-type stars at Z=0.002 rotate with a higher equatorial velocity at the ZAMS than stars with Z=0.014, our finding would indicate that the angular momentum content of B-type stars in the SMC is higher than their Galactic counterparts.
description: 15 pages, Accepted for publication in A&A
On Time in Quantum Physics
Creators: name: Butterfield, Jeremy
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: First, I briefly review the different conceptions of time held by three rival interpretations of quantum theory: the collapse of the wave-packet, the pilot-wave interpretation, and the Everett interpretation (Section 2). Then I turn to a much less controversial task: to expound the recent understanding of the time-energy uncertainty principle, and indeed of uncertainty principles in general, that has been established by such authors as Busch, Hilgevoord and Uffink. Although this may at first seem a narrow topic, I point out connections to other conceptual topics about time in quantum theory: for example, the question under what circumstances there is a time operator (Section 4.3).
description: 26 pages; no figures
Response to MLN8237 in Pancreatic Cancer Is Not Dependent on RalA Phosphorylation
Creators: name: Ecsedy, J. A.
name: Yeh, J. J.
name: Stratford, J. K.
name: Der, C. J.
name: Neel, N. F.
name: Shinde, V.
name: Martin, T. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The high prevalence of KRAS mutations and importance of the RalGEF-Ral pathway downstream of activated K-Ras in pancreatic ductal adenocarcinoma (PDAC) emphasize the importance of identifying novel methods by which to therapeutically target these pathways. It was recently demonstrated that phosphorylation of RalA S194 by Aurora A kinase is critical for PDAC tumorigenesis. We sought to evaluate the Aurora A kinase-selective inhibitor MLN8237 as a potential indirect anti-RalA targeted therapy for PDAC. We utilized a site-specific phospho-S194 RalA antibody and determined that RalA S194 phosphorylation levels were elevated in a subset of PDAC cell lines and human tumors relative to unmatched normal controls. Effects of MLN8237 on anchorage-independent growth in PDAC cell lines and growth of patient-derived xenografts (PDX) were variable, with a subset of cell lines and PDX showing sensitivity. Surprisingly, RalA S194 phosphorylation levels in PDAC cell lines or PDX tumors did not correlate with MLN8237 responsiveness. However, we identified Ki67 as a possible early predictive biomarker for response to MLN8237 in PDAC. These results indicate that MLN8237 treatment may be effective for a subset of PDAC patients independent of RalA S194 phosphorylation. Ki67 may be an effective pharmacodynamic biomarker to identify response early in the course of treatment.