cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing
Creators: name: Wang, Jing
name: Li, Ruiyu
name: Li, Junjie
name: Yi, Yuting
name: Liu, Xiaoding
name: Chen, Jingci
name: Zhang, Hui
name: Lu, Junliang
name: Li, Cami
name: Wu, Huanwen
name: Liang, Zhiyong
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. List of genes included in the 1021 genes panel.
Smooth distributions are finitely generated
Creators: name: Drager, Lance D.
name: Lee, Jeffrey M.
name: Park, Efton
name: Richardson, Ken
Publisher: name: arXiv
Year: 2010
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 57R15, 57R30, 57R25

description: A subbundle of variable dimension inside the tangent bundle of a smooth manifold is called a smooth distribution if it is the pointwise span of a family of smooth vector fields. We prove that all such distributions are finitely generated, meaning that the family may be taken to be a finite collection. Further, we show that the space of smooth sections of such distributions need not be finitely generated as a module over the smooth functions. Our results are valid in greater generality, where the tangent bundle may be replaced by an arbitrary vector bundle.
description: 13 pages
Lung Deposition Using the Respimat® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis
Creators: name: Anna-Maria Ciciliani
name: Denny, Mark
name: Langguth, Peter
name: Voshaar, Thomas
name: Wachtel, Herbert
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Tiotropium and olodaterol are mainstay treatments for chronic obstructive pulmonary disease (COPD) and yield important clinical improvements, especially when used in fixed-dose combination. Whilst previous studies have shown consistent delivery of tiotropium to the lungs with the Respimat® inhaler, no such study has been carried out for olodaterol or the components of their fixed-dose combination (TIO/OLO). Combining in vitro and in silico models, we measured the amount of drug retained in the mouth–throat area, entering the trachea and reaching the lung periphery. We applied a hybrid deposition model that considered the experimentally determined output of an Alberta throat model (in vitro – dose to lung) combined with a computational fluid dynamic model of the lungs (in silico). Regardless of the COPD breathing pattern, ≥50% of the nominal dose of either tiotropium, olodaterol, or TIO and OLO in the fixed-dose combination reached the lung. Of the dose reaching the lungs, greater than 50% is deposited in the lung periphery (from generation 8 onwards). Our study demonstrated that aerosol delivery via the Respimat inhaler achieved high deposition deep into the lung periphery with all formulations evaluated.
PSMA-SPECIFIC ANTIBODY FRAGMENTS FOR PROSTATE CANCER IMAGING AND THERAPY
Creators: name: FRIGERIO, BARBARA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: In this study we want to evaluate the potentiality of the use of a single chain Fv (scFv) for molecular imaging and therapy of Prostate Cancer. The target of this scFv is the Prostate Specific Membrane Antigen (PSMA), a type II transmembrane protein overexpressed in advances stages of this disease. In the past we have generated the murine antibody D2B recognizing hPSMA, whose diagnostic specificity has been investigated in xenograft murine models by imaging.
In order to obtain a smaller protein able to better penetrate the tissues we decided to convert the murine monoclonal antibody D2B into a format like scFv. This format, due to its smaller size, have also the advantage, compare to the entire antibody, to have a faster clearance from the blood.
The scFv has been constructed and its functionality has been tested with success on LNCaP cells. Using BIAcore (a technology able to measure the kinetic interaction between two molecules) we showed that the affinity of our scFv is still remarkable despite its monovalent binding.
One goal of the present study is the assessment of potential role of this antibody fragment as diagnostic reagent for the development of radiopharmaceuticals for tumor characterization and molecular imaging. A second goal of the project is the production of a completely human antibody fragment against hPSMA in order to develop a reagent more suitable for therapy. We used phage display technology to convert the murine antibody in a human antibody applying guided selection technology which permits to generate an antibody with the specificity and functionality of the starting rodent mAb.
Analysis of interdiffusion between SmFeAsO0.92F0.08 and metals for ex situ fabrication of superconducting wire
Creators: name: Fujioka, Masaya
name: Matoba, Masanori
name: Ozaki, Toshinori
name: Takano, Yoshihiko
name: Kumakura, Hiroaki
name: Kamihara, Yoichi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We demonstrate the fabrication of superconducting SmFeAsO1-xFx (Sm-1111) wires by using the ex-situ powder-in-tube technique. Sm-1111 powder and a binder composed of SmF3, samarium arsenide, and iron arsenide were used to synthesize the superconducting core. Although the F content of Sm-1111 is reduced in the process of ex-situ fabrication, the binder compensates by sufficiently supplementing the F content, thereby preventing a decrease in the superconducting transition temperature and a shrinking of the superconducting volume fraction. Thus, in the superconducting Sm-1111 wire with the binder, the transport critical current density reaches the highest value of ~4000 A/cm2 at 4.2 K.
Non-conventional green strategies for NHC catalyzed carbon-carbon coupling reactions
Creators: name: Mommahed Heravi, Majid
name: Heidari, Bahareh
name: Ghavidel, Mahdieh
name: Tahereh, Ahmadi
Publisher: name: figshare
Year: 2022
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30701 Quantum Chemistry
subject: 39904 Organometallic Chemistry
subject: 40204 Organic Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30504 Organic Green Chemistry
subject: 30303 Optical Properties of Materials

description: Background: Coupling reactions, commonly can be achieved via a wide range of organometallic reagents and electrophiles, representing an important class of synthetic transformation, namely cross-coupling reaction. It is frequently catalyzed by various palladium (Pd) as species. The synthesis and characterization of an N-heterocyclic carbine (NHC) was accomplished in 1991. In 1991, the first synthesis of a stable NHC was achieved and reported. Objective: This development literally invigorated the interest and attention for this novel species being examined as a ligand for the synthesis of Pd Complexes. Conclusion: In this review, we tried to give a full account on the development of NHC Pd chemistry intended being used as catalyst under non-conventional conditions. In this light, those carbon-carbon bond formations being successfully achieved in aqueous systems, using immobilized NHC-Pd complexes under nonconventional strategies, such as being conducted under microwave irradiations (MWI) are supported and solvent- free conditions are discussed.
Additional file 3 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
Creators: name: Zeng, Zhenhao
name: He, Wenrui
name: Jiang, Yi
name: Jiang, Hao
name: Cheng, Xiaofeng
name: Deng, Wen
name: Zhou, Xiaochen
name: Zhang, Cheng
name: Wang, Gongxian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3 Figure S3. The original images for Western blot in artical. The bands were visualized using the ImageQuant LAS 500.
D2.4 Molecular characterization of TOMRES genotypes
Creators: name: Luisa Lanfranco,
name: Bendahmane, Abdelhafid
name: Benhamed, Moussa
name: Gomez-Roldan, Maria Victoria
name: Lanfranco, Luisa
name: Chialva, Matteo
name: Novero, Mara
name: Cardinale, Francesca
name: Russo, Giulia
name: Visentin, Ivan
name: Batelli, Giorgia
name: Grillo, Stefania
name: Maggio, Albino
name: Ruggiero, Alessandra
name: J Van Oosten, Michael
name: Savaldi-Goldstein, Sigal
Publisher: name: Zenodo
Year: 2021

description: Report covering findings related to unbiased molecular characterization of novel genotypes or of lines pre-existing TOMRES and that are being used in TOMRES to investigate tomato responses to combined stress, and/or endowed with superior W/NUE (including but not limited to epigenome and transcriptome).
On Two Models of the Light Pulse Delay in a Saturable Absorber
Creators: name: Zapasskii, V. S.
name: Kozlov, G. G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A comparative analysis of two approaches to description of the light modulation pulse delay in a saturable absorber is presented. According to the simplest model, the delay of the optical pulse is a result of distortion of its shape due to absorption self-modulation in the nonlinear medium. The second model of the effect, proposed at the beginning of our century, connects the pulse delay with the so-called "slow light" resulting from the group velocity reduction under conditions of the coherent population oscillations. It is shown that all the known experimental data on the light pulse delay in saturable absorbers can be comprehensively described in the framework of the simplest model of saturable absorber and do not require invoking the effect of coherent population oscillations with spectral hole-burning and anomalous modifications of the light group velocity. It is concluded that the effect of group velocity reduction under conditions of coherent population oscillations has not received so far any experimental confirmation, and the assertions about real observation of the "slow light" based on this mechanism are groundless.
description: Regretfully, the journal version of the paper (in Optics and Spectroscopy) appeared to be strongly corrupted due to ignorant editing. In particular, "coherent population oscillations" (CPO) was replaced by "population coherent oscillations" (PCO), "bleaching" - by "clearing", and "bleachable absorber " - by "clearable absorber". Here we present original version of the paper
Ratios of heavy hadron semileptonic decay rates
Creators: name: Gronau, Michael
name: Rosner, Jonathan L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Ratios of charmed meson and baryon semileptonic decay rates appear to be satisfactorily described by considering only the lowest-lying (S-wave) hadronic final states and assuming the kinematic factor describing phase space suppression is the same as that for free quarks. For example, the rate for $D_s$ semileptonic decay is known to be $(17.0 \pm 5.3)%$ lower than those for $D^0$ or $D^+$, and the model accounts for this difference. When applied to hadrons containing $b$ quarks, this method implies that the $B_s$ semileptonic decay rate is about 1% higher than that of the nonstrange $B$ mesons. This small difference thus suggests surprisingly good local quark-hadron duality for $B$ semileptonic decays, complementing the expectation based on inclusive quark-hadron duality that these differences in rates should not exceed a few tenths of a percent. For $Λ_b$ semileptonic decay, however, the inclusive rate is predicted to be about 13% greater than that of the nonstrange $B$ mesons. This value, representing a considerable departure from a calculation using a heavy quark expansion, is close to the corresponding experimental ratio $Γ(Λ_b)/ \bar Γ(B) = 1.13 \pm 0.03$ of total decay rates.
description: 12 pages, no figures. References added
Seeing the patient as a person in interprofessional health professions education
Creators: name: Bosveld, Matthijs Hugo
name: Romme, Sjim
name: de Nooijer, Jascha
name: Smeets, Hester Wilhelmina Henrica
name: van Dongen, Jerôme Jean Jacques
name: van Bokhoven, Marloes Amantia
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Increasing prevalence of chronic disease leads to an increased need for person-centered care. To prepare future health professionals for this need, educational institutions provide interprofessional education in which they actively involve patients (hereafter called experts by experience). The organization of inter-institutional, interprofessional education with the active involvement of experts by experience poses challenges. To overcome these challenges, a joint student- and expert by experience-led organization was established, named Patient as a Person Foundation. This organization functions as the linking pin between three educational institutions. Jointly, they enabled the involvement of 181 experts by experience in interprofessional education and 1313 students from nine study programs over the course of two curriculum years. To facilitate joint education involving patients, Patient as a Person Foundation realizes three main activities: (a) recruitment and instruction of experts by experience, (b) enabling the inter-institutional organization of education and facilitating its logistics and financing, and (c) universal training of teaching staff. This interprofessional Education and Practice Guide aims to provide lessons on how to sustainably organize interprofessional education involving experts by experience across multiple educational institutions. The key lessons provided in this guide, underpinned by research and key literature, aim to inspire and enable similar initiatives elsewhere.
Essay on labour supply in transition economies.
Creators: name: YULDASHEV, OYBEK
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: This study highlights the factors that influence individual hours of work decision in fi ve transition economies. Employing the modifi ed Heckman estimation procedure the
study fi nds positive and modest wage elasticities of labour supply in all the countries reviewed. This finding is consistent with stylized fact that those countries which inherited high labor force participation rates are relatively insensitive to changes in the wage rates.
Apart from wages such factors as age, marital status, type of settlement, employee
occupation, educational attainment, the presence of children and non-labour income
are found to explain signi cantly labour supply behavior in the countries studied.
Chemotactic predator-prey dynamics
Creators: name: Sengupta, Ankush
name: Kruppa, Tobias
name: Löwen, Hartmut
Publisher: name: arXiv
Year: 2010
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Biological Physics (physics.bio-ph)
subject: Medical Physics (physics.med-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: A discrete chemotactic predator-prey model is proposed in which the prey secrets a diffusing chemical which is sensed by the predator and vice versa. Two dynamical states corresponding to catching and escaping are identified and it is shown that steady hunting is unstable. For the escape process, the predator-prey distance is diffusive for short times but exhibits a transient subdiffusive behavior which scales as a power law $t^{1/3}$ with time $t$ and ultimately crosses over to diffusion again. This allows to classify the motility and dynamics of various predatory bacteria and phagocytes. In particular, there is a distinct region in the parameter space where they prove to be infallible predators.
description: 4 pages, 4 figures
A non-singular integral equation formulation of permeable semi-infinite hydraulic fractures driven by shear-thinning fluids
Creators: name: Gomez, Daniel
Publisher: name: University of British Columbia
Year: 2016

description: This thesis considers the problem of semi-infinite hydraulic fractures driven by shear-thinning power-law fluids through a permeable elastic medium. In the recent work by Dontsov and Peirce [Journal of Fluid Mechanics, 784:R1 (2015)], the authors reformulated the governing equations in a way that avoids singular integrals for the case of a Newtonian fluid. Moreover, the authors constructed an approximating ordinary differential equation (ODE) whose solutions accurately describe the fracture opening at little to no computational cost. The present thesis aims to extend their work to the more general case where the fracture is driven by a shear-thinning power-law fluid. In the first two chapters of this thesis we outline the relevant physical modelling and discuss the asymptotic propagation regimes typically encountered in hydraulic fracturing problems. This is followed by Chapters 4 and 5 where we reformulate the governing equations as a non-singular integral equation, and then proceed to construct an approximating ODE. In the final chapter we construct a numerical scheme for solving the non-singular integral equation. Solutions obtained in this way are then used to gauge the accuracy of solution obtained by solving the approximating ODE. The most important results of this thesis center on the accuracy of using the approximating ODE. In the final chapter we find that when the fluid's power-law index is in the range of 0.4 ≤ n ≤ 1, an appropriate method of solving the approximating ODE yields solutions whose relative errors are less than 1%. However, this relative error increases with decreasing values of n so that in the range 0 ≤ n < 0.4 it reaches a maximum value of approximately 6%. Thus, at least for values of 0.4 ≤ n ≤ 1 the approximating ODE presents an accurate and computationally fast alternative to solving the semi-infinite problem. The same can't be said for values of 0 ≤ n < 0.4, but the methods presented in this thesis may be used as a starting point for future work in this direction.
Femtoscopy of the system shape fluctuations in heavy ion collisions
Creators: name: Voloshin, Sergei A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Dipole, triangular, and higher harmonic flow that have an origin in the initial density fluctuations has gained a lot of attention as they can provide additional important information about the dynamical properties (e.g. viscosity) of the system. The fluctuations in the initial geometry should be also reflected in the detail shape and velocity field of the system at freeze-out. In this talk I discuss the possibility to measure such fluctuations by means of identical and non-identical particle interferometry.
description: 4 pages, Proceedings of Quark Matter 2011 Conference, May 23 - May 28, Annecy, France
Einsatz von Nickel-Katalysatoren zum Cracken von Teerprodukten aus der Niederdruckaufkohlung von Stahl mit Ethin
Creators: name: Mbadinga Mouanda, Gelase
Publisher: name: Karlsruhe
Year: 2009
Subjects: Aufkohlung
Härten
Katalysator
Abgasbehandlung
Pyrolyse

description: Die Niederdruckaufkohlung von Stahl ist ein modernes Verfahren, das zur Einsatzhärtung von Stahlbauteilen dient. Bei Temperaturen zwischen 900 und 1050 °C und Drücken unter 50 mbar werden Bauteile durch heterogene Pyrolyse von Ethin in einem Ofen einsatzgehärtet. Das während der Pyrolyse erzeugte Abgas enthält aromatische Kohlenwasserstoffe und kann katalytisch behandelt werden. Der Katalysator wird durch Rußablagerung desaktiviert und muss zyklisch durch Verbrennung mit Luft regeneriert werden.
IL DIRITTO ALL'ISTRUZIONE. STATO DI ATTUAZIONE E FINANZIAMENTO DEL SISTEMA NELLA PROSPETTIVA DEL FEDERALISMO FISCALE
Creators: name: FAGNANI, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: The present contribution intends to define the meaning of constitutional prescriptions related to the social right to education and to identify the current role of this right as it results from the recently started reformation processes which are modifying the overall educational system features.
Particularly, it defines the present regulatory framework and the structure of the distribution of the competences due to 2001 constitutional Reform, in the light of the constitutional jurisprudence. Besides the definition of the notion of ?right to education? and of its components, the analysis focuses the attention on its concrete uses, with particular regard to the actuation of the said right as it is realized by the regional government.
Finally, this dissertation analyses the funding system of Italian school, up to now mainly state centered, to find out who has at his disposal the financial and human levers. As a conclusion, the compatibility regarding the transfer of the function from the State to the local administration (fulfilled or not) has been verified as to the present funding system and the attribution of the availability of the levers to the various level of governance, also in prospect of the complex reform process, named ?fiscal federalism?.
EVALUATION OF L-ARGININE/NITRIC OXIDE METABOLIC PATHWAY IN ERYTHROCYTES IN RELATION WITH OXIDATIVE STRESS: FOCUS ON DIFFERENT CARDIOVASCULAR DISEASES
Creators: name: PORRO, BENEDETTA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Background: A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. Recent studies have shown that red blood cells (RBCs) participate in NO formation in the bloodstream.
Aim: The aim of this study was to assess the L-arginine (Arg)/NO pathway and the oxidative stress status in RBCs and in plasma of patients with microvascular angina (MVA), investigating similarities and differences with respect to coronary artery disease (CAD) patients or healthy controls (Ctrl).
Materials and Methods: Analytes involved in Arg/NO pathway and the ratio between the oxidized and the reduced forms of glutathione, as index of oxidative stress, were measured by liquid-chromatography tandem mass spectrometry (LC-MS/MS). The arginase and the NO synthase (NOS) expression were assessed by immunofluorescence staining. NOS activity was evaluated by ex-vivo experiments through the conversion of L-[15N2]arginine to L-[15N]citrulline.
Results: Both MVA and CAD patients showed alterations in the ability of RBCs to produce NO, based on an increase of NO synthesis inhibitors, parallel to that found in plasma, a reduction of NOS expression and activity and an increased arginase expression. When summary scores of NO synthesis and of oxidative stress were computed, both patient groups were associated with a positive oxidative score and a negative NO score, with the CAD group located in a more extreme position with respect to Ctrl.
Conclusions: This finding points out to an impairment of the capacity of RBCs to produce NO in pathological conditions characterized by alteration at the microvascular bed with/without no significant coronary stenosis.
Accurate ionic forces and geometry optimisation in linear scaling density-functional theory with local orbitals
Creators: name: Hine, N. D. M.
name: Robinson, M.
name: Haynes, P. D.
name: Skylaris, C. -K.
name: Payne, M. C.
name: Mostofi, A. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Linear scaling methods for density-functional theory (DFT) simulations are formulated in terms of localised orbitals in real-space, rather than the delocalised eigenstates of conventional approaches. In local-orbital methods, relative to conventional DFT, desirable properties can be lost to some extent, such as the translational invariance of the total energy of a system with respect to small displacements and the smoothness of the potential energy surface. This has repercussions for calculating accurate ionic forces and geometries. In this work we present results from \textsc{onetep}, our linear scaling method based on localised orbitals in real-space. The use of psinc functions for the underlying basis set and on-the-fly optimisation of the localised orbitals results in smooth potential energy surfaces that are consistent with ionic forces calculated using the Hellmann-Feynman theorem. This enables accurate geometry optimisation to be performed. Results for surface reconstructions in silicon are presented, along with three example systems demonstrating the performance of a quasi-Newton geometry optimisation algorithm: an organic zwitterion, a point defect in an ionic crystal, and a semiconductor nanostructure.
description: 11 pages, 9 figures
Electronic Structure of Novel Superconductor Ca4Al2O6Fe2As2
Creators: name: Miyake, Takashi
name: Kosugi, Taichi
name: Ishibashi, Shoji
name: Terakura, Kiyoyuki
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have performed the first-principles electronic structure calculation for the novel superconductor Ca4Al2O6Fe2As2 which has the smallest a lattice parameter and the largest As height from the Fe plane among the Fe-As superconductors. We find that one of the hole-like Fermi surfaces is missing around the Gamma point compared to the case of LaFeAsO. Analysis using the maximally-localized-Wannier-function technique indicates that the xy orbital becomes more localized as the As-Fe-As angle decreases. This induces rearrangement of bands, which results in the change of the Fermi-surface topology of Ca4Al2O6Fe2As2 from that of LaFeAsO. The strength of electron correlation is also evaluated using the constraint RPA method, and it turns out that Ca4Al2O6Fe2As2 is more correlated than LaFeAsO.
description: 5 pages, 6 figures, 2 tables
Dynamics of one-dimensional electron systems
Creators: name: Küchel, Tobias
Publisher: name: Karlsruhe
Year: 2009
Subjects: Hubbard model
spin-charge separation
correlated electron systems

description: We investigate the separation of spin and charge in interacting one-dimensional fermion systems. Density matrix renormalisation group (DMRG) simulations on the Hubbard model in the time domain show this phenomenon explicitely in a transport scenario. The separation of internal degrees of freedom and charge even remains when extending the problem to SU(3) fermions. Additionally, identifying signatures for spinon and holon are found for the momentum-dependent spectral function in a magnetic field.
Coercivity and the Calderon Operator on an Unbounded Domain
Creators: name: Ritterbusch, Sebastian
Publisher: name: Karlsruhe
Year: 2009
Subjects: Maxwell equations
Calderon operator
Coercivity
Integral operators
Weak solutions
Scattering theory

description: Detection of metallic objects in soil lead to the mathematical model of Maxwell's equations in a two-layered space. The full space problem is reduced to a weak formulation for a half-space with a non-local boundary condition using the exterior Calderon operator. For non-dissipative media the Calderon operator exhibits singular spectral properties at the infinite boundary plane. Using weighted Sobolev spaces the weak formulation is uniquely solvable by generalized coercivity conditions.
THE EFFECT OF INTERNATIONAL POLICIES ON BORROWING AND DEBT OF DEVELOPING COUNTRIES
Creators: name: BUA, GIOVANNA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: The first paper introduces a new dataset on the stock and structure of domestic debt in 36 Low-Income Countries over the period 1971-2011. We characterize the recent trends regarding LICs domestic public debt and explore the relevance of different arguments put forward on the benefits and costs of government borrowing in local public debt markets. The main stylized fact emerging from the data is the increase in domestic government debt since 1996. We also observe that poor countries have been able to increase the share of long-term instruments over time and that the maturity lengthening went together with a decrease in borrowing costs. However, the concentration of the investor base, mainly dominated by commercial banks and the Central Bank, may crowd out lending to the private sector.
TeRRItoria D3.1 Inventory of bottom-up governance innovation practices
Creators: name: Mezzana, Daniele
name: Caiati, Giovanni
name: Berliri, Maresa
name: Signore, Paolo
Publisher: name: Zenodo
Year: 2019
Subjects: Bottom-up governance, RRI,

description: This document contains an Inventory of 30 bottom-up governance innovation practices (called for convenience BUGIPs) realized within the framework of the TeRRItoria project. It is part of a broader work aiming at identifying useful examples, in terms of approaches, policies and tools, for the development of the 5 “Transformative Experiments” the project will implement. The Inventory focuses on those governance innovations, promoted by different kind of coalitions, that activate a process of “re-territorialisation”, i.e. they work for reversing de-territorialisation trends and thus to foster local development and social cohesion. In particular, the Inventory collects the experiences in which research and innovation actors, in different ways, exercise responsibility toward their territory as they play a pivotal role in governance innovation. The focus is on governance innovation that emerges in the territories as a “social processes” rather than as the application of a plan or a project based on top-down investments or funds, e.g. at European or at the national level.
 The features of the BUGIPs included in the inventory are summarised in the following points. BUGIPs consists of the establishment of new relationships between different social actors none of whom being able, by themselves, to control the social complexity; BUGIPs are focused on the management of a shared territorial challenge and not on the pursue of pre-established interests, thus overcoming the contrapositions among representatives of the various actors involved; BUGIPs represent an inclusive way in which R&I actors exercise their responsibility through strategically cooperating with other territorial actors: BUGIPs are understood as open social processes rather than an implementation of fund-based plans or projects.
How cytoskeleton senses abiotic/biotic stimuli in plant cells?
Creators: name: Qiao, Fei
Publisher: name: Karlsruhe
Year: 2010
Subjects: cytoskeleton
elicitor
grapevine
tabacco VBI-3
auxin transport

description: In der vorliegenden Arbeit wurde die Funktion des Cytoskeletts in der Perzeption von biotischen und abiotischen Reizen untersucht. Als Indikator der zellulären Antwort wurde die Synchronität der Zellteilung gewählt, während als biotischer Reiz ein durch einen elicitor simulierter Pathogenbefall und als abiotischer Reiz Licht genutzt wurde. Die Ergebnisse zeigen eine unterschiedliche Antwort des Cytoskeletts auf diese beiden Reize hinsichtlich Reorganisation und Signaltransduktion.
VARIATIONAL PROBLEMS INVOLVING NON-LOCAL ELLIPTIC OPERATORS
Creators: name: FISCELLA, ALESSIO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: My thesis deals with nonlinear elliptic problems involving a non-local integrodifferential operator of fractional type. Our main results concern the existence of weak solutions for these problems and they are obtained using variational and topological methods.
Effect of carrier doping on the formation and collapse of magnetic polarons in lightly hole-doped La_{1-x}Sr_xCoO_3
Creators: name: Podlesnyak, A.
name: Ehlers, G.
name: Frontzek, M.
name: Sefat, A. S.
name: Furrer, A.
name: Straessle, Th.
name: Pomjakushina, E.
name: Conder, K.
name: Demmel, F.
name: Khomskii, D. I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the doping dependence of the nanoscale electronic and magnetic inhomogeneities in the hole-doping range 0.0020.05, dominated by Co^{3+}-Co^{3+} intracluster interactions. Our conclusions are in good agreement with a recently proposed model of the phase separation in cobalt perovskites [He et al., Europhys. Lett. 87, 27006 (2009)].
Regulation der Sporenkeimung und des Sekundärmetabolismus durch Licht in Aspergillus nidulans
Creators: name: Kastner, Christian
Publisher: name: Karlsruhe
Year: 2010
Subjects: Aspergillus
Licht
Keimung
Sekundärmetabolismus

description: Licht ist ein allgegenwärtiges Signal, dass vielen Organismen wichtige Informationen über ihren Standort, ihre Umgebung oder die Tageszeit liefert. In Aspergillus nidulans wird die Keimung der Sporen wie auch die weitere Entwicklung durch Licht reguliert. Licht verzögert das Keimen der Sporen. Darüber hinaus hat Licht einen Einfluss auf die Bildung des Mycotoxins Sterigmatocystin und das Antibiotikum Penicillin. Die Wirkung des Lichts hängt allerdings maßgeblich von den Nährstoffbedingungen ab.
The application of optical satellite imagery and census data for urban population estimation: A case study for Ahmedabad, India
Creators: name: Nolte, Eike-Marie
Publisher: name: Karlsruhe
Year: 2010
Subjects: population estimation
remote sensing
census
India
megacities
GIS
disaster management

description: The rapid growth of India's urban population leads to the need to employ new technologies for population modelling. In this study,
optical satellite images and census data are used to model the population distribution for the city of Ahmedabad (northwest India. The selected spatial scales for which the population data are generated correspond to those often used for earthquake risk modelling and loss estimation.
Application of electrospray ionization mass spectrometry towards the elucidation of free radical polymerization mechanisms
Creators: name: Pin Siong Koo, Sandy
Publisher: name: Karlsruhe
Year: 2010
Subjects: Acrylate
midchain radicals
backbiting
mass spectrometry
polymer
pulsed laser polymerization
acrylate branching

description: The present thesis contributes to fundamental knowledge of acrylate polymerizations, particularly with respect to midchain radicals and the subsequent reactions they can undergo through an in-depth investigation of the mediating ability of 1-octanethiol on
n-butyl acrylate FRP, followed by the synthesis of high purity macromonomer obtained in an optimized reaction. Arrhenius parameters for the propagation rate coefficient of methyl acrylate and 2-ethylhexyl acrylate in bulk are also determined.
Expecting a ring and finding a round : sequence and order in George Herbert's The Temple
Creators: name: Warner, Matthew Gordineer
Publisher: name: University of British Columbia
Year: 2016

description: This thesis is concerned with the sequential nature of George Herbert’s The Temple. By engaging with this volume of poetry as a cohesive unit with structures that extend beyond any one poem, it is shown that that although Herbert’s poetry is richly productive, it is also limited and self-undermining, expressing the ultimately contingent nature of human art. The structures examined are of two kinds, dealt with in turn: first, those that are typographical and emerge from the physical presentation of Herbert’s poems on the pages of the first edition of 1633, and second, formal structures modelled by particular poems in the collection, which provide insight and reflection into the functioning of the whole. In the first category are poems that share common titles (“Love” (I), “Love” (II), “Love” (III), for example) as well as the particular arrangements of poems such as “Hope” and “Sinnes Round” on the page, which suggest connections and relationships between these poems that are not apparent when viewed individually or in the abstract. The second kind of feature examined is found in a wide variety of Herbert’s poems, and is the tendency of these poems to model particular kinds of reading practice that are applicable to the reading of The Temple itself. Poems such as “Prayer” (I) and “The Sacrifice” exhibit modes of accumulation and revision that suggest how multiple poems may be combined to produce larger structures of meaning, while poems such as “The Flower” and “The Pulley” demonstrate how such structures are necessarily incomplete and flawed. Finally, a turn to the poems “Vertue” and “Love” (III) explores how Herbert’s poetry engages with questions of finitude and conclusion.
Path description of type B q-characters
Creators: name: Mukhin, E.
name: Young, C. A. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Algebra (math.QA)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We give a set of sufficient conditions for a Laurent polynomial to be the q-character of a finite-dimensional irreducible representation of a quantum affine group. We use this result to obtain an explicit path description of q-characters for a class of modules in type B. In particular, this proves a conjecture of Kuniba-Ohta-Suzuki.
description: 32 pages, latex
UTILIZZO DI UNA METODICA INNOVATIVA E NON INVASIVA PER CONTROLLARE LA SINTOMATOLOGIA INFIAMMATORIA DURANTE IL DECORSO POST OPERATORIO IN INTERVENTI DI IMPLANTOLOGIA
Creators: name: MAGISTRO, MANUELA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: CONTROL OF POSTOPERATIVE DISCOMFORT BY LOCAL PHYSICAL THERAPY AFTER ORAL SURGERY

ABSTRACT

PURPOSE

Surgical treatment in implantology and dental surgery is a common procedure that often accompanied by pain, swelling and trismus.
Many patients in their postoperative complain situations of disconfot and reduced of quality of life.
The aim of the present study was to investigate how controll postoperative morbidities, whether the local application of elastic therapeutic tape (KT).

MATERIALS ANS METHODS

To adress the research purpose, the investigators designed and implemented a multicentric study with parallel-group. Patients were prospectively assigned for treatment of unilateral and bilateral implant placement and allocated to receive treatment with or without KT application according to joint patient and clinicial decision.
KT was applied directly by the same Physical Terapist after surgery and maintained for 3 days postoperatively. Facial swelling was quantified using the Laskin Method to misure inflammation, through three misurament pre surgery, post surgery after 24 hours, and 48 hours (DHS, DHC, DV,WHI). Pain score was assessed using a 0-10 level Visual Analog Scale, and pain drawing.
Mouth opening was measured, with the Laskin method using a millimeter ruler.
In addition, all patients were asked to evaluate overall satisfaction and swelling and the effect of the tape on movement and comfort after KT application, between a quality of life scale evaluation.
Inclusion criteria were: unilateral elevation of maxillary sinus, multiple implant placement, simple tooth extractions, unilateral or bilateral impacted upper and lower third molars extraction.
Exclusion criteria were: patients younger than 18 years, pregnant or lactating women, sensitivities to tape, unwillingness to shave facial hair, known allergies to medication used in the study. Patients developing unforeseen inflammatory reactions after surgery.

RESULTS

50 patients were investigate but only 30 patients were included in the study respected on inclusion criteria (17 female and 13 male; mean age KT, 57.7 yr; standard deviation KT, 12.4 yr; mean age no KT, 56.7 yr; standard deviation no KT, 12.1 yr). Application of KT after surgery for implantology had a statistically significant influence on tissue reaction and swelling, decreasing the incidence of swelling and turgidity by more than 30% inthe first 2-3 days post surgery. Although KT had significant influence on reducing pain control, patients perceived significantly lower morbidity.

CONCLUSION

The present results showed that the application of KT after implantology susrgery is a promising, simple, a-traumatic, and economical approach for managing postoperative swelling and pain that is free from systemic adverse reactions, for improving quality of life of our patients.
Keywords: Kinesio tape, implantology, dental surgery, pain, swelling, morbidity
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW SUBTYPE SELECTIVE KAINATE RECEPTOR LIGANDS
Creators: name: MASTRONARDI, FEDERICA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Glutamate receptors are the principal mediators of the excitatory transmission in the CNS. These proteins are divided into two big families: metabotropic and ionotropic receptors (mGluRs and iGluRs). Among iGluRs, kainate receptors (KARs) are of remarkable interest because they have a modulatory role and, for this reason, they could be ideal drug targets. Moreover, since kainate receptors are formed by five different type of subunits (GluK1-5) and each of them seems to be related to different neorological disorder, is much more fascinating to search for subunit-selective compounds.
On this ground, I have designed and synthesized a series of compounds using the structure/backbone of the non-selective AMPA/KA agonists L-Glutamate, L-Tricholomic acid and CIP-AS. The design strategy included the homologation of the amino acidic chain and the increase of molecular complexity, which aimed at producing respectively a modification of the profile from agonist to antagonist and selectivity toward KARs subunits. All the new derivatives were pharmacologically characterized through the evaluation of their binding affinity for native ionotropic glutamate receptors and for recombinant homomeric GluK1-3 receptors.
The attained results support the proposed strategy, since some very selective compounds have been identified. In particular, compound 1f show a very high GluK1 selectivity (Ki= 0.464 �M), while amino acids 9a and 9d are GluK3 selective ligands (Ki= 0.206 ?M and 0.117 ?M, respectively). Notably, compound 9a displayed a 10-fold selectivity for GluK3 versus GluK2 and a 35-fold selectivity for GluK3 versus GluK1. Even more interestingly, compound 9d showed a 26-fold selectivity for GluK3 versus GluK2 and a 70-fold selectivity for GluK3 versus GluK1, being the most selective GluK3 ligand yet ever discovered. Therefore, compound 9d represents a valuable probe for characterizing the molecular determinants of subunit-selective binding and could represent an ideal pharmacological tool for investigating the patho-physiological role played by the least characterized GluK3 subtype.
In conclusion, amino acid chain homologation coupled to the insertion of bulkier substituents into the L-Glutamate/CIP-AS backbones has allowed the establishment of additional interactions/steric clashes with specific amino acidic residues, which have in turn determined selectivity for the specific KAR subtype GluK1 or GluK3. The molecular determinants of the observed selectivity will be clarified through crystallographic studies on the GluK1 and GluK3 LBD, which are currently in due course, and these results will pave the way to the development of further highly potent and selective GluK receptor antagonists.
Reversible Addition-Fragmentation Chain Transfer-Hetero Diels-Alder (RAFT-HDA) Chemistry as an Efficient Conjugation Technique for Macromolecular Surface Engineering
Creators: name: Nebhani, Leena
Publisher: name: Karlsruhe
Year: 2010
Subjects: RAFT
Diels-Alder
Surface Modification
Microspheres
Silicon Wafer
Fullerenes
Solid-State NMR
Reversible Cross-linking
Grafting Density
Click Chemistry

description: In the current study - to achieve the modification of solid substrates in an efficient fashion - the next generation of RAFT agents capable of rapidly undergoing HDA reactions under ambient conditions and in the absence catalyst were synthesized. In addition, a range of highly innovative protocols for the orthogonal modification of variety solid substrates were established. The microspheres were also studied to obtain information about the amount of accessible active sites and grafting densities.
On the metric structure of space-time
Creators: name: Rau, Jochen
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: I present an analysis of the physical assumptions needed to obtain the metric structure of space-time. For this purpose I combine the axiomatic approach pioneered by Robb with ideas drawn from works on Weyl's "Raumproblem". The concept of a Lorentzian manifold is replaced by the weaker concept of an "event manifold", defined in terms of volume element, causal structure and affine connection(s). Exploiting properties of its structure group, I show that distinguishing Lorentzian manifolds from other classes of event manifolds requires the key idea of general relativity: namely that the manifold's physical structure, rather than being fixed, is itself a variable.
Hysteretic magnetoresistance and thermal bistability in a magnetic two-dimensional hole system
Creators: name: Wurstbauer, Ursula
name: Śliwa, Cezary
name: Weiss, Dieter
name: Dietl, Tomasz
name: Wegscheider, Werner
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Colossal negative magnetoresistance and the associated field-induced insulator-to-metal transition, the most characteristic features of magnetic semiconductors, are observed in n-type rare earth oxides and chalcogenides, p-type manganites, n-type and p-type diluted magnetic semiconductors (DMS) as well as in quantum wells of n-type DMS. Here, we report on magnetostransport studies of Mn modulation-doped InAs quantum wells, which reveal a magnetic field driven and bias voltage dependent insulator-to-metal transition with abrupt and hysteretic changes of resistance over several orders of magnitude. These phenomena coexist with the quantised Hall effect in high magnetic fields. We show that the exchange coupling between a hole and the parent Mn acceptor produces a magnetic anisotropy barrier that shifts the spin relaxation time of the bound hole to a 100 s range in compressively strained quantum wells. This bistability of the individual Mn acceptors explains the hysteretic behaviour while opening prospects for information storing and processing. At high bias voltage another bistability, caused by the overheating of electrons10, gives rise to abrupt resistance jumps.
Background Investigations of the KATRIN Pre-Spectrometer
Creators: name: Fränkle, Florian M.
Publisher: name: Karlsruhe
Year: 2010
Subjects: KATRIN
Pre-Spectrometer
Background
Radon
Penning-Trap

description: Measurements and analysis methods of this thesis have revealed that an electrostatic retarding spectrometer (MAC-E filter) with a rather large magnetic shielding is essentially a background-free device, if both the effects from Penning traps and Radon emanation processes are controlled by careful design and appropriate counter measures (e.g. LN2 baffles).