cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil
Creators: name: Somrudee Saiyudthong
name: Sirinun Pongmayteegul
name: Marsden, Charles A.
name: Pansiri Phansuwan-Pujito
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Neuroscience
subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry

description: Vetiver essential oil (VEO) has been used in aromatherapy for relaxation. This study aimed to investigate the effects of VEO on an anxiety-related behavioural model (the elevated plus-maze, EPM) and immediate-early gene c-fos in amygdala, known to be involved in anxiety. Male Wistar rats were administered diazepam (1 mg/kg i.p.) for 30 min or inhalated with VEO (1%, 2.5% or 5% w/w) for 7 min prior to exposure to the EPM. Then, the effects of 2.5% VEO, the anxiolytic dose, on c-fos expression in amygdala were investigated. The rats given either 2.5% VEO or diazepam exhibited an anxiolytic-like profile in the EPM. VEO and diazepam significantly increased c-fos expression in the lateral division of the central amygdaloid nucleus (CeL). Therefore, the anxiolytic properties of VEO might be associated with altering neuronal activation in CeL. However, future studies are needed to investigate the precise mechanism of action of VEO.
In vitro antioxidant and antiproliferative activities of six international basil cultivars
Creators: name: Hosam O. Elansary
name: Mahmoud, Eman A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Microbiology
subject: Biochemistry

description: The total phenolic, flavonoid and tannin contents in leaves extracts of Ocimum basilicum (OB) (Lamiaceae) international cultivars, as well as their overall antioxidant activities using DPPH and linoleic acid assays, were investigated. Furthermore, the antiproliferative and cytotoxic activities against line HeLa, MCF-7, Jurkat, HT-29, T24, MIAPaCa-2 cancer cells and one normal human cell line HEK-293 were examined. DPPH and linoleic acid assays ranged from 75.8% to 93.3% and from 74.5% to 97.1%; respectively. O. b. ‘purple ruffle’, O. b. ‘dark opale’, O. b. ‘genovese’, O. b. ‘anise’, O. b. ‘bush green’ and O. b. L. (OBL) varied in their antiproliferative and cytotoxic activities, influenced cell cycle progression and stimulated apoptosis in most cancer cells. OBL exhibited the highest antioxidant and antiproliferative activities. OB extracts not only improve taste but also have certain anticancer activity against diverse cancer cells due to the presence of compounds such as rosmarinic acid, chicoric acid and caftaric acid. Thus, OB represents a potent source of anticancer materials.
Investigation of 1P-LSD as a Novel Drug Therapy for Autism Spectrum Disorders
Creators: name: Foster, Kayla
name: Hansen, Abigail
name: Lee, Matthew
name: Mohammed, Alan
name: Morrell, Matthew
name: Nguyen, Thach-Vu
name: Olson, Caroline
name: Pascale, Lucas
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: Animal & Avian Sciences
AGNR
Team Acid
Gemstone
Autism Spectrum Disorders
1P-LSD

description: Autism spectrum disorders (ASD), defined by repetitive behaviors or impaired social communication, is a prevalent yet relatively misunderstood set of conditions. ASD encompasses a series of neurodevelopmental disorders that have various physiological manifestations (Goines & Ashwood, 2013). Due to the heterogeneity of ASD, the true mechanisms leading to the development of ASD and its symptoms remain unclear and require more research (Rossignol & Frye, 2012; Watts, 2008). The purpose of this project is to test whether or not 1P-LSD, an analogue of LSD (lysergic acid diethylamide), has the potential to treat symptoms of ASD, specifically the hyperexcitation of N-methyl-D-aspartate (NMDA) receptors in the brain which causes the neuronal excitotoxicity highly implicated in the pathology of ASD.We will determine the two highest doses of 1P-LSD which does not result in any hallucinogenic side effects in Phase 1 of this protocol and utilize these doses towards treatment of symptoms associated with ASD in the Phase 2 of this protocol. We will monitor N-methyl-D-aspartate (NMDA) receptor activity, which is usually impaired in ASD, following microdosing of 1P-LSD. Towards these experiments, we will be using an autistic mouse model, Slc6a4, compared to normal mice (C57BL/6J). The efficacy of the treatment model will be assessed by measuring the levels of a subunit of the NMDA receptor, the NR2B subunit, using with western blotting and immunohistochemistry, and by measuring the levels of glutamate using gas chromatography-mass spectrometry (GCMS).
Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana
Creators: name: Ndongo, Joseph T.
name: Issa, Mark E.
name: Messi, Angelique N.
name: Mbing, Joséphine Ngo
name: Cuendet, Muriel
name: Pegnyemb, Dieudonné E.
name: Bochet, Christian G.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Genetics
subject: Biochemistry

description: Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3′,4′-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective
Creators: name: Vizetto-Duarte, Catarina
name: Pereira, Hugo
name: Sousa, Carolina Bruno De
name: Rauter, Amélia Pilar
name: Albericio, Fernando
name: Custódio, Luísa
name: Barreira, Luísa
name: Varela, João
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry

description: The fatty acid (FA) composition of six macroalgae from the Cystoseira genus, namely Cystoseira compressa, Cystoseira humilis, Cystoseira tamariscifolia, Cystoseira nodicaulis, Cystoseira baccata and Cystoseira barbata, was determined. Polyunsaturated fatty acids (PUFA) corresponded to 29–46% of the total FA detected. C. compressa, C. tamariscifolia and C. nodicaulis stood out for their low PUFA/saturated fatty acid, low n-6 PUFA/n-3 PUFA ratios as well as favourable unsaturation, atherogenicity and thrombogenicity indices, suggesting a high nutritional value with potential applications in the nutraceutical industry.
Effects of High Carbohydrate Supplementation on Hepatic Mitochondrial Metabolism
Creators: name: Zhang, Christine
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: Animal & Avian Sciences
AGNR
Zhang
Maryland Summer Scholars
Metabolism
Mitochondria
Carbohydrate Supplementation

description: Non-alcoholic fatty liver disease (NAFLD) is a major public health issue affecting over 75 million patients and over 70% of patients that suffer from Type 2 Diabetes Mellitus and obesity. Previous research has demonstrated that progression of NAFLD is accompanied by liver mitochondria adaptation and eventual dysfunction as they fail to respond to the influx of free fatty acids and the metabolic actions of insulin. The aim of this study was to elucidate the effects of high carbohydrate supplementation on mitochondrial metabolism, specifically the tricarboxylic acid (TCA) cycle, of hepatocytes utilizing a metabolomics centered approach. Data obtained through gas chromatography mass spectrometry (GC/MS) suggest that LF and HC fed animals exhibit higher mitochondrial (TCA) activity compared to their HF counterparts. Short-term increased mitochondrial activity suggests an increased robust metabolic response, however, long-term effects may be detrimental to metabolic flexibility through increased production of reactive oxygen species. While the comprehensive effects of high carbohydrate supplementation on metabolism are still under investigation, these results suggest that diets high in carbohydrates may lead to exacerbation of mitochondria, and ultimately metabolic dysfunction.
Chemical composition, phytotoxic and antifungal properties of Ruta chalepensis L. essential oils
Creators: name: Bouabidi, Wafa
name: Hanana, Mohsen
name: Gargouri, Samia
name: Amri, Ismail
name: Fezzani, Tarek
name: Ksontini, Mustapha
name: Jamoussi, Bassem
name: Hamrouni, Lamia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: The chemical composition, and phytotoxic and antifungal activities of the essential oils isolated by using hydrodistillation from the aerial parts of Tunisian rue were evaluated. Significant variations were observed among harvest periods. The analysis of the chemical composition by gas chromatography/mass spectrometry showed that 2-undecanone (33.4–49.8%), 2-heptanol acetate (13.5–15.4%) and α-pinene (9.8–11.9%) were the main components. The antifungal ability of rue essential oils was tested by using disc agar diffusion against ten plant pathogenic fungi. A high antifungal activity was observed for the essential oil isolated at flowering developmental phase. Furthermore, rue essential oils showed high level of herbicidal activity against several weeds.
Preparation of magnetic nanocomposite beads and optimizing the conditions for effective removal of U(VI) from aqueous solutions
Creators: name: Tavengwa, Nikita Tawanda
name: Cukrowska, Ewa
name: Chimuka, Luke
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine
subject: Physics
subject: Engineering
subject: Biochemistry

description: Magnetic ion-imprinted polymers (IIPs) were prepared by precipitate polymerization and leached with HCl to remove uranium. Their ability to remove hexavalent uranium from wastewater effluents was studied. Batch adsorption studies to determine the optimum conditions of U(VI) removal were conducted at different levels of sample pH, sorbent amount, agitation time, and initial uranium concentration. It was observed that, under optimum conditions (i.e. pH 4, adsorbent amount of 50 mg, 45 min agitation time, and initial U(VI) concentration of 2 mg L−1), the maximum removal of U(VI) cations was >98% and 80% for the magnetic IIP and the corresponding magnetic non-imprinted polymers (NIP), respectively. Langmuir and Freundlich isotherms were used to describe the adsorption of U(VI) onto magnetic IIP and NIP. The adsorption capacity of U(VI) was determined to be 1.06 and 0.85 mg g−1 for the two isotherms, respectively. The order of selectivity was found to be U(VI) > Fe(III) > Pb(II). For six cycles of regeneration and reuse, the magnetic polymers maintained their stabilities with only a 4% loss in the extraction efficiency. The average extraction efficiencies of the magnetic polymers for the spiked acid mine drainage and sewage wastewater effluents were 71% and 58% for the magnetic IIP and NIP, respectively. From powder X-ray diffraction analysis, application of the Scherrer equation yielded magnetic nanoparticles of an average mean diameter of 11.9 nm. Thermo-gravimetric analysis revealed that the HCl-leached magnetic polymers had a magnetite residual weight of 5%.
Lo que los trabajadores quieren vs. lo que las empresas necesitan. Implementación de las anclas de carrera de Edgar Schein en un contact centre
Creators: name: Cortés-Sánchez, Julián David
name: Grueso-Hinestroza, Merlín-Patricia
Publisher: name: Universidad del Rosario
Year: 2016

description: El compromiso laboral entre los trabajadores y las organizaciones es uno de los activos con mayor poder explicativo para consolidar un alto desempeño e incrementar la productividad. Para lograr eso es fundamental conocer cuáles son las vocaciones de los trabajadores actuales y futuros y de qué manera estas motivaciones de carrera encuentran articulación con la misión y la visión de la compañía. El problema es que las empresas fallan sistemáticamente en este proceso. El modelo de anclas de carrera (ac) de Edgar Schein es una metodología que permite conocer cuáles son las motivaciones de carrera de los individuos. Este documento tiene como propósito establecer un vínculo entre las ac y los procesos de selección, vinculación, y retención del capital humano en un contact centre que se desempeña en Bogotá, Colombia. Para alcanzar este propósito, se implementó el modelo de ac en una muestra de 116 trabajadores del área de gestión de esta compañía. El informe presenta el análisis de resultados y las propuestas sugeridas por los autores a la gerencia de la compañía.
title: Forecasting Recessions in Canada: An Autoregressive Probit Model Approach
Creators: name: Poulin-Moore, Antoine
name: Tuzcuoglu, Kerem
Publisher: name: Bank of Canada
publisherIdentifier: https://ror.org/05cc98565
publisherIdentifierScheme: ROR
Year: 2024

description: We forecast recessions in Canada using an autoregressive (AR) probit model. In this model, the presence of the lagged latent variable, which captures the autocorrelation in the recession binary variable, results in an intractable likelihood with a high dimensional integral. Therefore, we employ composite likelihood methods to facilitate the estimation of this complex model, and we provide their asymptotic results. We perform a variable selection procedure on a large variety of Canadian and foreign macro-financial variables by using the area under the receiver operating characteristic curve (AUROC) as the performance criterion. Our findings suggest that the AR model meaningfully improves the ability to forecast Canadian recessions, relative to a variety of probit models proposed in the Canadian literature. These results are robust to changes in the performance criteria or the sample considered. Our findings also highlight the short-term predictive power of US economic activity and suggest that financial indicators are reliable predictors of Canadian recessions.
description: Nous prévoyons les récessions au Canada à partir d’un modèle probit autorégressif. Dans ce modèle, la présence d’une variable latente retardée, qui reflète l’autocorrélation de la variable binaire indicatrice de récession, se traduit par une vraisemblance incalculable contenant une intégrale de haute dimension. Ainsi, nous employons des méthodes de vraisemblance composite pour faciliter l’estimation de ce modèle complexe, puis nous en présentons les résultats asymptotiques. Nous appliquons une procédure de sélection à une grande variété de variables macrofinancières canadiennes et étrangères en utilisant comme critère de performance la surface sous la courbe de la fonction d’efficacité du récepteur. Selon nos résultats, le modèle autorégressif améliore considérablement la capacité de prévision des récessions au Canada, comparativement à divers autres modèles probit proposés dans la littérature canadienne. Ces résultats sont robustes aux changements dans les critères de performance ou l’échantillon utilisé. Par ailleurs, ils mettent en relief le pouvoir prédictif à court terme de l’activité économique aux États-Unis, et semblent montrer que les indicateurs financiers peuvent servir à prédire de manière fiable les récessions au Canada.
Preparation of magnetic nanocomposite beads and optimizing the conditions for effective removal of U(VI) from aqueous solutions
Creators: name: Tavengwa, Nikita Tawanda
name: Cukrowska, Ewa
name: Chimuka, Luke
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine
subject: Physics
subject: Engineering
subject: Biochemistry

description: Magnetic ion-imprinted polymers (IIPs) were prepared by precipitate polymerization and leached with HCl to remove uranium. Their ability to remove hexavalent uranium from wastewater effluents was studied. Batch adsorption studies to determine the optimum conditions of U(VI) removal were conducted at different levels of sample pH, sorbent amount, agitation time, and initial uranium concentration. It was observed that, under optimum conditions (i.e. pH 4, adsorbent amount of 50 mg, 45 min agitation time, and initial U(VI) concentration of 2 mg L−1), the maximum removal of U(VI) cations was >98% and 80% for the magnetic IIP and the corresponding magnetic non-imprinted polymers (NIP), respectively. Langmuir and Freundlich isotherms were used to describe the adsorption of U(VI) onto magnetic IIP and NIP. The adsorption capacity of U(VI) was determined to be 1.06 and 0.85 mg g−1 for the two isotherms, respectively. The order of selectivity was found to be U(VI) > Fe(III) > Pb(II). For six cycles of regeneration and reuse, the magnetic polymers maintained their stabilities with only a 4% loss in the extraction efficiency. The average extraction efficiencies of the magnetic polymers for the spiked acid mine drainage and sewage wastewater effluents were 71% and 58% for the magnetic IIP and NIP, respectively. From powder X-ray diffraction analysis, application of the Scherrer equation yielded magnetic nanoparticles of an average mean diameter of 11.9 nm. Thermo-gravimetric analysis revealed that the HCl-leached magnetic polymers had a magnetite residual weight of 5%.
Improving Google glass security and privacy by changing the physical and software structure
Creators: name: Safavi, Seyedmostafa
Publisher: name: figshare
Year: 2015
Subjects: subject: Computer Engineering
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Theoretical Computer Science
subject: Applied Computer Science

description: Following the exciting first reactions, Google Glass has encountered seriously criticism, due to the
perceived threats to security and privacy. Cyber security is one of the most serious threats, both to private users and business enterprises. At present, Google Glass makes it easy for cyber hackers to gain access to our personal data, banking and credit card details, passwords or personal identification numbers. After conducting literature review and simple questionnaire survey in which 35 Glass owners and 30 privacy managers from the US took part, we analyzed the collected data to point out the weakness of the device. The response rate visibly showed problem of user privacy in design of product (16.7% satisfaction on design to protect privacy). Based on these analyses, we proposed 6 essential improvements to Glass security and privacy by redesigning the features that currently pose a threat to privacy of Google Glass users and other party involved. We can thus view Google Glass as an opportunity to draw attention to modern privacy concepts. It is likely that, given that the risks associated with Google Glass are being widely discussed, the threats have been around for much longer.
Gobierno electrónico: diagnóstico de eficiencia en municipios del programa MuNet II – Caso Panamá
Creators: name: Wong, Maribel
name: Cardona, Diego
name: Cortés-Sánchez, Julián David
Publisher: name: Universidad del Rosario
Year: 2014

description: Este documento tiene el objetivo de presentar los resultados del diagnóstico de eficiencia en 26 municipios de Panamá durante la implementación del Programa de Gobierno Electrónico de la Organización de los Estados Americanos –oea– denominado Municipios Eficientes y Transparentes –MuNet–. Este diagnóstico se efectuó en los gobiernos municipales para obtener una visión general sobre factores relacionados con el manejo financiero y administrativo, las compras y obras públicas, la prestación de servicios públicos y los trámites que efectúa el gobierno municipal. Inicialmente se realizará una revisión sucinta del concepto de eficiencia dentro del contexto de gobierno electrónico. Posteriormente se describirá el contexto general y la metodología empleada en los municipios participantes del programa MuNet en su segunda fase de implementación en Panamá.
Reviews on Cybercrime Affecting Portable Devices
Creators: name: Safavi, Seyedmostafa
Publisher: name: figshare
Year: 2015
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: Computer Engineering
subject: Computer Software
subject: Theoretical Computer Science

description: The popularity of mobile devices in the market is impressive, but this influx of different products has made it difficult for users to secure their infrastructures from potential data breaches. As the number of exposures and attacks increase, there has been a corresponding rise in security solutions offered by researchers. This article reviews the literature to prevent the cybercrime affecting portable devices especially smartphones running Android OS. Extant researches are analyzed and opportunities for
future research are identified. Four research questions have been developed and out of 493 articles retrieved, 33 articles have been selected to be analyzed. From the analysis, we have found that Data leakage resulting from device loss or theft,
unintentional disclosure of data and phishing attacks are most common between attackers.
With no doubt, security investigators have stressed the grandness of protecting classified personal data residing in Android portable devices. They have suggested to use the permission-based security model and behavior-based detection method for
protecting classified information. In result we found that Android OS can handle and apply the integrated protection model but still there are opportunities for us to improve the security of personal data.
Conceptual Privacy Framework for Health Information on Wearable Device
Creators: name: Safavi, Seyedmostafa
Publisher: name: figshare
Year: 2015
Subjects: subject: Computer Engineering
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Theoretical Computer Science
subject: Applied Computer Science

description: Wearable health tech provides doctors with the ability to remotely supervise their patients' wellness. It also makes it much easier to authorize someone else to take appropriate actions to ensure the person's wellness than ever before. Information Technology may soon change the way medicine is practiced, improving the performance, while reducing the price of healthcare. We analyzed the secrecy demands of wearable devices, including Smartphone, smart watch and their computing techniques, that can soon change the way healthcare is provided. However, before this is adopted in practice, all devices must be equipped with sufficient privacy capabilities related to healthcare service. In this paper, we formulated a new improved conceptual framework for wearable healthcare systems. This framework consists of ten principles and nine checklists, capable of providing complete privacy protection package to wearable device owners. We constructed this framework based on the analysis of existing mobile technology, the results of which are combined with the existing security standards. The approach also incorporates the market share percentage level of every app and its respective OS. This framework is evaluated based on the stringent CIA and HIPAA principles for information security. This evaluation is followed by testing the capability to revoke rights of subjects to access objects and ability to determine the set of available permissions for a particular subject for all models Finally, as the last step, we examine the complexity of the required initial setup.
Inferencia estadística módulo de regresión lineal simple
Creators: name: Cárdenas Vallejo, Edwin
name: Rivera Lozano, Miller
name: Gonzalez-Rodriguez, Javier-Leonardo
name: Cardona, Diego
Publisher: name: Universidad del Rosario
Year: 2013

description: La utilización del modelo de regresión lineal en los procesos relacionados con el análisis de datos demanda el conocimiento objetivo e instrumentación de la relación funcional de variables, el coeficiente de determinación y de correlación y la prueba de hipótesis como pilares fundamentales para verificar e interpretar su significancia estadística en el intervalo de confianza determinado. La presentación específica de los temas relacionados con el modelo de regresión lineal, el análisis de regresión, el uso de la ecuación de regresión como instrumento para estimar y predecir y la consideración del análisis de residuales ha sido realizada tomando como referente el estudio de problemas reales definidos en los entornos de la economía, la administración y la salud, utilizando como plataforma de apoyo la hoja de cálculo Excel®. Se consideran en este módulo didáctico, los elementos teóricos correspondientes al análisis de regresión lineal, como técnica estadística empleada para estudiar la relación entre variables determinísticas o aleatorias que resultan de algún tipo de investigación, en la cual se analiza el comportamiento de dos variables, una dependiente y otra independiente. Se muestra mediante la gráfica de dispersión el posible comportamiento de las variables: lineal directa, inversa, no lineal directa o no lineal inversa, con el fin de desarrollar en el lector las competencias interpretativas y propositivas requeridas para dimensionar integralmente la importancia de la estadística inferencial en la vida del profesional en ciencias económicas, administrativas y de la salud.
Análisis de la industria del té y las aromáticas en Colombia
Creators: name: Rivera-Rodriguez, Hugo-Alberto
name: Malaver-Rojas, Marleny-Natalia
name: Botero Riveros, Diana
name: Zapata Castaño, Gabriela
name: Suarez Daza, Ricardo Esteban
name: Álvarez, Juan Felipe
Publisher: name: Universidad del Rosario
Year: 2011

description: En el año 2010, en la Facultad de Administración de la Universidad delRosario se formalizó el proyecto de investigación en turbulencia empresarialen Colombia con la finalidad de avanzar en la generación de alternativaspara los directores de empresas sobre cómo pueden enfrentar el dinamismo,la incertidumbre y la complejidad del entorno. Se incorporaron estudiantesde pregrado y posgrado a la línea de investigación en estrategia, lo que diocomo resultado la publicación, entre junio del 2010 y junio del 2011, de másde quince documentos de investigación. Se identifican elementos comunessobre la manera en que las empresas se enfrentan a la turbulencia; es el casode la gestión de los stakeholders, la generación de capacidades dinámicasy la gestión de mejoramiento continuo. Este documento, desarrollado de forma conjunta por los profesores Malavery Rivera de la asignatura Estrategia de Empresa I y con estudiantes depregrado del programa de Administración de Negocios Internacionales yAdministración de Empresas, permite comprender de un modo mejor elcomportamiento del sector del té y aguas aromáticas en Colombia. Este estudiopretende contribuir al trabajo del grupo de investigación. Para ello serealiza un análisis estratégico del sector en el período comprendido entre losaños 2005 y 2010. Se utilizan algunas de las herramientas de la metodologíadesarrollada por Restrepo y Rivera (2008), denominada “análisis estructuralde sectores estratégicos”. Al final del escrito, se hará un análisis paraestablecer los elementos que permiten a las empresas perdurar en el tiempoa pesar de convivir con un entorno turbulento.
Conservation of transcriptional sensing systems in prokaryotes: A perspective from Escherichia coli
Creators: name: Heladia Salgado
name: Martínez-Antonio, Agustino
name: Sarath Chandra Janga
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Microbiology

description: Here, we introduce the notion of ‘‘triferog’’, which relates to the identification of orthologous transcription factors and effector genes across genomes and show that transcriptional sensing systems known in E. coli are poorly conserved beyond Salmonella. We also find that enzymes that act as effector genes for the production of endogenous effector metabolites are more conserved than their corresponding effector genes encoding for transport and two-component systems for sensing exogenous signals. Finally, we observe that on an evolutionary scale enzymes are more conserved than their respective TFs, suggesting a homogenous cellular metabolism across genomes and the conservation of transcriptional control of critical cellular processes like DNA replication by a common endogenous signal. We hypothesize that extensive variation in the domain architecture of TFs and changes in endogenous conditions at large phylogenetic distances could be the major contributing factors for the observed differential conservation of TFs and their corresponding effector genes encoding for enzymes, causing variations in transcriptional responses across organisms.
COMPARATIVE MECHANISMS FOR TRANSCRIPTION AND REGULATORY SIGNALS IN ARCHAEA AND BACTERIA
Creators: name: Martínez-Antonio, Agustino
name: Collado-Vides, Julio
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Microbiology

description: A review and comparisosn of genetic regulatory mechanisms in archaea and bacteria.
Proposal for a Minimal DNA Auto-Replicative System
Creators: name: Martínez-Antonio, Agustino
name: Espíndola-Serna, Laura
name: Quiñones-Valles, César
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: Microbiology

description: DNA replication allows cell division and population growth of living organisms. Here we will focus on DNA replication in prokaryotic single celled microorganisms.
Understanding the Relationship Between Theory of Mind and Anxiety in Autistic and Typically Developing Children
Creators: name: Stadler, Ryan
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: subject: Psychology
subject: FOS: Psychology
subject: BSOS
subject: Stadler
subject: Child Psychology
subject: Autism
subject: Anxiety

description: Anxiety disorder can be especially difficult to deal with for children and adolescents. Previous literature has indicated a relationship between anxiety and theory of mind ability. Theory of mind (ToM) is the ability to understand the beliefs, emotions, and intentions of another person and acknowledge that these mental states may differ from their own. Previously, individuals diagnosed with social anxiety disorder demonstrated lower ToM ability than their peers. However, these studies used a limited number of tasks and a sample of only typically developing (TD) adults. The relationship between anxiety and ToM is less understood when the presence of autism spectrum disorder (ASD) is considered. Understanding anxiety in children with ASD is important because they are diagnosed with anxiety disorder at a higher rate compared to their TD peers. To explore this relationship in both ASD and TD samples, data was collected using the Strange Stories Task and the Screening for Child Anxiety Related Disorders (SCARED) questionnaire for 44 participants ages 7-14 years old. 22 participants had an ASD diagnosis and 22 did not. Strange Stories assesses ability to accurately use ToM to answer questions about characters’ mental states in fictional stories. The SCARED questionnaire is completed by parents to evaluate how much anxiety is typically experienced by the child. From these data, the correlation between ToM accuracy and total anxiety score will be examined. Differences in ToM and anxiety scores between groups will also be investigated. The results could allow for better understanding of ToM and anxiety in children with and without autism.
Regulation by transcriptionfactors in bacteria:beyond description
Creators: name: Balleza, Enrique
name: López-Bohorquez, Lucia N.
name: Martínez-Antonio, Agustino
name: Osbaldo Resendis-Antonio
name: Lozada-Chávez, Irma
name: Yalbi Balderas-Martínez
name: Collado-Vides, Julio
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Molecular Biology
subject: Microbiology

description: In this review, we transmit the main ideas or concepts behind regulation by transcription factors and give just enough examples to sustain these main ideas, thus avoiding a classical ennumeration of facts. We review recent concepts and developments: cis elements and trans regulatory factors, chromosome organization and structure, transcriptional regulatory networks (TRNs) and transcriptomics. We also summarize new important discoveries that will probably affect the direction of research in gene regulation: epigenetics and stochasticity in transcriptional regulation, synthetic circuits and plasticity and evolution of TRNs. Many of the new discoveries in gene regulation are not extensively tested with wetlab approaches. Consequently, we review this broad area in Inference of TRNs and Dynamical Models of TRNs. Finally, we have stepped backwards to trace the origins of these modern concepts, synthesizing their history in a timeline schema.
title: 3 - Ashiq Mehbub ve Ashiq Novruz (آشیق محبوب و آشیق نوروز)
Publisher: name: Maison des Sciences de l’Homme de Clermont-Ferrand
Year: 2013

description: Voyage de Koroğlu à Tékké-Turkmène        Koroğlu qui n’a pas d’enfant, mène une  expédition à Tékké-Turkmène pour adopter un jeune homme à ses yeux digne de sa  succession. Il retrouve Eyvaz, le jeune homme repéré par son aşiq. Or, le père  du garçon résiste. Koroğlu insiste, menace et implore…Il finit par faire  d’Eyvaz, son fils adoptif et son successeur.
Operation of the Gene Regulatory Network in Escherichia coli
Creators: name: Martínez-Antonio, Agustino
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: Microbiology

description: In this chapter I present the advances of what we know about the mechanistic logic for the operation of the regulatory programme in E. coli. It is proposed that for a better understanding on the operation of the regulatory network it should be considered the globalism of transcription factors, the signal perceived by each, their co-regulating activity, the genome position of regulatory and target genes, and cellular concentration of the regulatory proteins, among others.
Problemas estructurales de empresas del sector agrícola y subsidio recurrente a otros sectores económicos en América Latina
Creators: name: Reyes-Ortiz, Giovanni-Efrain
Publisher: name: Universidad del Rosario
Year: 2012

description: La finalidad fundamental de este artículo es discutir dos rasgos esenciales delsector agrícola: primero, los problemas económico-productivos estructuralesque le son propios, segundo, abordar el rasgo de subsidio macroeconómicoque este sector ha realizado recurrentemente, a otros sectores económicosy sociales en América Latina. Se incluye en el último rasgo, repercusionesde este subsidio en las características de vida de la región, en especial lapobreza y la carencia de efectiva inclusión social. Una de las principalesconclusiones es que, mientras este esquema se mantenga, la región continuarárelegando este sector económico y aumentarán los rasgos de vulnerabilidadeconómica en los países.
Inferencia estadística módulo de regresión lineal simple
Creators: name: Rivera Lozano, Miller
name: Cárdenas Vallejo, Edwin
name: Gonzalez-Rodriguez, Javier-Leonardo
name: Cardona, Diego
Publisher: name: Universidad del Rosario
Year: 2013

description: La utilización del modelo de regresión lineal en los procesos relacionadoscon el análisis de datos demanda el conocimiento objetivo e instrumentaciónde la relación funcional de variables, el coeficiente de determinacióny de correlación y la prueba de hipótesis como pilares fundamentales paraverificar e interpretar su significancia estadística en el intervalo de confianzadeterminado.La presentación específica de los temas relacionados con el modelo deregresión lineal, el análisis de regresión, el uso de la ecuación de regresióncomo instrumento para estimar y predecir y la consideración del análisisde residuales ha sido realizada tomando como referente el estudio de problemasreales definidos en los entornos de la economía, la administracióny la salud, utilizando como plataforma de apoyo la hoja de cálculo Excel®.
Gobierno electrónico : diagnóstico de participación ciudadana en municipios del programa MuNet II – Caso Panamá
Creators: name: Cardona, Diego
name: Cortés-Sánchez, Julián David
name: Wong, Maribel
Publisher: name: Universidad del Rosario
Year: 2013

description: Este documento tiene el objetivo de presentar los resultados del diagnósticode participación ciudadana realizado en 28 municipios de Panamá durantela implementación del Programa de Gobierno Electrónico de la Organizaciónde los Estados Americanos –Oea– denominado Municipios Eficientesy Transparentes –MuNet–.
Turbulencia empresarial en Colombia : el caso del sector cementero
Creators: name: Ortega Torres, Fernando
name: Leal Vergara, Carlos
name: Figueroa García, Laura
name: Archila Saa, Helen
name: Rivera-Rodriguez, Hugo-Alberto
Publisher: name: Universidad del Rosario
Year: 2011

description: La línea de Investigación en Estrategia, perteneciente al Grupo de Investigaciónen Perdurabilidad (GIPE) de la Facultad de Administración de laUniversidad del Rosario, se ha dedicado en los últimos cinco años a estudiarla forma como las empresas enfrentan la turbulencia del entorno. En los años2010 y 2011 se han llevado a cabo estudios en sectores como el automotriz,lácteos, bebidas no alcohólicas, cosméticos, farmacéutico, alimentos, postres,aire acondicionado, salud, cines, químicos; etc. Los hallazgos encontradoshan mostrado que para enfrentar la turbulencia de industria, las empresasacuden, principalmente, al desarrollo de capacidades dinámicas.Dando continuidad a esta investigación, el presente documento, elaboradoen coautoría con estudiantes de pregrado de la Facultad de Administración,detalla la manera como algunas empresas del sector cementero enfrentaronla turbulencia presentada en el período que comprende los años de 2000 a2010.
The comprehensive updated regulatory network of Escherichia coli K-12
Creators: name: Heladia Salgado
name: Santos-Savaleta, Alberto
name: Gama-Castro, Socorro
name: Peralta-Gil, Martín
name: Peñaloza-Spinola, Monica
name: Martínez-Antonio, Agustino
name: Karp, Peter
name: Collado-Vides, Julio
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Molecular Biology
subject: Microbiology

description: One hundred and fifty new interactions have been added to our databases as a result of this specific curation effort, in addition to those added as a result of our continuous curation work. RegulonDB gene names are now based on those of EcoCyc to avoid confusion due to gene names and synonyms, and the public releases of RegulonDB and EcoCyc are henceforth synchronized to avoid confusion due to different versions. Public flat files are available providing direct access to the regulatory network interactions thus avoiding errors due to differences in database modelling and representation. The regulatory network available in RegulonDB and EcoCyc is the most comprehensive and regularly updated electronically-encoded regulatory network of E. coli K-12.
Indicador de perdurabilidad empresarial
Creators: name: Méndez Velasco, Diego Andrés
name: Beltrán Torrado, Alejandro
name: Bernardo Cadena, Javier
name: Guzman, Alexander
name: Rivera-Rodriguez, Hugo-Alberto
Publisher: name: Universidad del Rosario
Year: 2006

description: En la búsqueda de respuestas a preocupaciones permanentes de los directoresy gerentes de empresas la medición de la perdurabilidad es un temapermanente de discusión y debate en sus organizaciones. En muchos casosla permanencia en el tiempo y la consecución de resultados financieros sealcanza sin lograr identificar con claridad las razones para lograrlo, o encaso contrario la desaparición de muchas empresas no ha sido explicadacompletamente.El presente documento de investigación presenta una alternativa para lamedición de la perdurabilidad empresarial y utiliza reflexiones estratégicasapoyadas en conceptos financieros.Lo presentado complementa la propuesta denominada “Análisis estructuralde sectores estratégicos” desarrollada por el grupo de investigaciónen perdurabilidad empresarial de la Facultad de Administración de la Universidaddel Rosario de Bogotá.
EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma
Creators: name: Dong, Qiongzhu
name: Du, Yi
name: Li, Hui
name: Liu, Chunxiao
name: Wei, Yongkun
name: Chen, Mei-Kuang
name: Zhao, Xixi
name: Chu, Yu-Yi
name: Qiu, Yufan
name: Qin, Lunxiu
name: Yamaguchi, Hirohito
name: Hung, Mien-Chie
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: PARP1 inhibitors (PARPi) are currently used in the clinic for the treatment of ovarian and breast cancers, yet their therapeutic efficacy against hepatocellular carcinoma (HCC) has been disappointing. To ensure therapeutic efficacy of PARPi against HCC, a disease often diagnosed at intermediate to advanced stages with no effective treatment options, it is critical to identify not only biomarkers to predict PARPi resistance but also rational treatments to overcome this. Here, we report that a heterodimer of EGFR and MET interacts with and phosphorylates Y907 of PARP1 in the nucleus, which contributes to PARPi resistance. Inhibition of both EGFR and MET sensitized HCC cells to PARPi, and both EGFR and MET are known to be overexpressed in HCC. This report provides an explanation for the poor efficacy of PARPi against HCC and suggests combinatorial treatment consisting of EGFR, MET, and PARP inhibitors may be an effective therapeutic strategy in HCC.Significance:Regulation of PARP by the c-MET and EGFR heterodimer suggests a potentially effective combination therapy to sensitize HCC to PARPi.
Other InformationPublished in: Cancer Research
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://doi.org/10.1158/0008-5472.can-18-1273
Reglamentación para la administración y supervisión del riesgo operativo en Colombia. Segunda entrega
Creators: name: Trujillo Dávila, María Andrea
name: Guzman, Alexander
name: Mosquera Torres, Andrei
Publisher: name: Universidad del Rosario
Year: 2009

description: El documento de investigación número 31 de la Facultad de Administración,titulado “Reglamentación para la administración y supervisión del riesgo operativoen Colombia”, presentó la investigación relacionada con los avancessobre la reglamentación y supervisión de este riesgo hasta febrero del 2006,no sin antes contextualizar al lector respecto al marco teórico, y los avancesrealizados en países como México y España. Esta segunda entrega se realizadebido a la pertinencia del tema y a la falta de conocimiento por parte de laacademia de lo que en el presente ocurre en las empresas. Este documentode investigación, además de presentar la indagación realizada respecto a lareglamentación para la administración y supervisión del riesgo operativoen Chile, Perú y Ecuador, pretende resaltar el trabajo realizado por AndreiMosquera Torres respecto al sistema administrativo de riesgo operacionalpara una sociedad comisionista de bolsa. El mencionado trabajo, desarrolladopor Andrei Mosquera para optar por el título como Profesional en Finanzas yComercio Internacional de la Universidad del Rosario, recoge su experienciarespecto a la administración del riesgo operativo (operacional) en una firmacomisionista de bolsa.
Modular analysis of the transcriptional regulatory network of E. coli
Creators: name: Osbaldo Resendis-Antonio
name: Freyre-González, Julio
name: Menchaca-Médez, Ricardo
name: Gutierrez-Rios, Rosa
name: Martínez-Antonio, Agustino
name: Avila-Sánchez, Christian
name: Collado-Vides, Julio
Publisher: name: figshare
Year: 2015
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Microbiology

description: The transcriptional network of Escherichia coli is currently the best-understood regulatory network of a single cell. Motivated by statistical evidence, suggesting a hierarchical modular architecture in this network, we identified eight modules with well-defined physiological functions. These modules were identified by a clustering approach, using the shortest path to trace regulatory relationships across genes in the network. We report the type (feed forward and bifan) and distribution of motifs between and within modules. Feed-forward motifs tend to be embedded within modules, whereas bi-fan motifs tend to link modules, supporting the notion of a hierarchical network with defined functional modules.
Simulando el análisis de hacinamiento sectorial en empresas colombianas
Creators: name: Mendoza Pulido, Iván Alfredo
name: Mendoza Saboya, Liliana Adriana
name: Gómez-Cruz, Nelson Alfonso
name: Maldonado, Carlos Eduardo
name: Ortega-Hurtado, Francisco-Fernando
name: Martínez, Johann H.
Publisher: name: Universidad del Rosario
Year: 2010

description: El objetivo de este trabajo es hacer una interpretación de la herramienta “hacinamientoestratégico” la cual fue propuesta por el profesor Luis F. Restrepo P.y Hugo A. Rivera en el año 2006 a través del Centro de Estudios Empresarialespara la Perdurabilidad. El análisis de hacinamiento es una herramienta quehace parte complementaria del Análisis Estructural de Sectores Estratégicos(AESE), la cual muestra la percepción de imitación que tiene una empresasobre un sector estratégico determinado.En este trabajo se presenta una interpretación formal de los planteamientosteóricos en los cuales se basa el hacinamiento; luego de la formalización sedesarrolla una simulación que muestra nuevas formas de observar la imitaciónen un sector estratégico. Las técnicas utilizadas para la nueva observación sonel análisis de discriminante, y la probabilidad condicional.