cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The effectiveness of microwave ablation in the treatment of liver tumours and correlation of the achieved ablation zone with the manufacturer's expected ablation zone
Creators: name: Doan, Emily
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Ablation procedures
subject: CT
subject: Interventional non-vascular
subject: Liver
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Hepatic lesions including hepatocellular carcinoma and metastases are a leading cause of cancer-related deaths worldwide. 1,2 Hepatectomy offers curative potential, however, concurrent cirrhosis and advanced disease stage often exclude surgical...
The jet and the disk of the HH 212 low-mass protostar imaged by ALMA: SO and SO2 emission
Creators: name: Podio, L.
name: Codella, C.
name: Gueth, F.
name: Cabrit, S.
name: Bachiller, R.
name: Gusdorf, A.
name: Lee, C. -F.
name: Lefloch, B.
name: Leurini, S.
name: Nisini, B.
name: Tafalla, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: To investigate the disk formation and jet launch in protostars is crucial to comprehend the earliest stages of star and planet formation. We aim to constrain the properties of the molecular jet and the disk of the HH 212 protostellar system at unprecedented angular scales through ALMA observations of sulfur-bearing molecules, SO 9(8)-8(7), SO 10(11)-10(10), SO2 8(2,6)-7(1,7). SO 9(8)-8(7) and SO2 8(2,6)-7(1,7) show broad velocity profiles. At systemic velocity they probe the circumstellar gas and the cavity walls. Going from low to high blue-/red-shifted velocities the emission traces the wide-angle outflow and the fast (~100-200 km/s) and collimated (~90 AU) molecular jet revealing the inner knots with timescales <50 years. The jet transports a mass loss rate >0.2-2e-6 Msun/yr, implying high ejection efficiency (>0.03-0.3). The SO and SO2 abundances in the jet are ~1e-7-1e-6. SO 10(11)-10(10) emission is compact and shows small-scale velocity gradients indicating that it originates partly from the rotating disk previously seen in HCO+ and C17O, and partly from the base of the jet. The disk mass is >0.002-0.013 Msun, and the SO abundance in the disk is ~1e-8-1e-7. SO and SO2 are effective tracers of the molecular jet in the inner few hundreds AU from the protostar. Their abundances indicate that 1% - 40% of sulfur is in SO and SO2 due to shocks in the jet/outflow and/or to ambipolar diffusion at the wind base. The SO abundance in the disk is 3-4 orders of magnitude larger than in evolved protoplanetary disks. This may be due to an SO enhancement in the accretion shock at the envelope-disk interface or in spiral shocks if the disk is partly gravitationally unstable.
description: 13 pages, 10 figures, accepted for publication by A&A
Additional file 2 of Effect of Omega-3 fatty acids supplementation on serum level of C-reactive protein in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Taha, Amira Mohamed
name: Shaarawy, Ahmad Shehata
name: Omar, Mohamed Mosad
name: Abouelmagd, Khaled
name: Shalma, Noran Magdy
name: Alhashemi, Mais
name: Ahmed, Hala Mahmoud
name: Allam, Ahmed Hafez
name: Abd-ElGawad, Mohamed
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2: Search strategy.
Employing Helicity Amplitudes for Resummation
Creators: name: Moult, Ian
name: Stewart, Iain W.
name: Tackmann, Frank J.
name: Waalewijn, Wouter J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Many state-of-the-art QCD calculations for multileg processes use helicity amplitudes as their fundamental ingredients. We construct a simple and easy-to-use helicity operator basis in soft-collinear effective theory (SCET), for which the hard Wilson coefficients from matching QCD onto SCET are directly given in terms of color-ordered helicity amplitudes. Using this basis allows one to seamlessly combine fixed-order helicity amplitudes at any order they are known with a resummation of higher-order logarithmic corrections. In particular, the virtual loop amplitudes can be employed in factorization theorems to make predictions for exclusive jet cross sections without the use of numerical subtraction schemes to handle real-virtual infrared cancellations. We also discuss matching onto SCET in renormalization schemes with helicities in $4$- and $d$-dimensions. To demonstrate that our helicity operator basis is easy to use, we provide an explicit construction of the operator basis, as well as results for the hard matching coefficients, for $pp\to H + 0,1,2$ jets, $pp\to W/Z/γ+ 0,1,2$ jets, and $pp\to 2,3$ jets. These operator bases are completely crossing symmetric, so the results can easily be applied to processes with $e^+e^-$ and $e^-p$ collisions.
description: 41 pages + 20 pages in Appendices, 1 figure, v2: journal version
O'ZBEKISTONDA GASTRONOMIK TURIZM: HOZIRGI TENDENSIYALAR VA ISTIQBOL.
Creators: name: Qilichov, Sobir
Publisher: name: Zenodo
Year: 2024

description: O‘zbekistonda gastronomik turizmni rivojlantirish tendensiyalarini o‘rganish hamda gastronomik turistik subyektlar faoliyatining iqtisodiy samaradorligining tahlilini amalga oshirish. Ushbu maqoladan ko‘zlangan asosiy maqsad gastronomik turizmning kelib chiqishi va uning mohiyatini keng yoritib berishdan iborat, chunki, bugungi kunda dunyoning rivojlangan juda ko‘plab davlatlarida turizmning asosiy turi sifatida gastronomik turizm etirof etilmoqda, negaki gastronomik turizm sohasini jadal rivojlantirish iqtisodiy o‘sishning muhim omili sanaladi. Shu tufayli gastronomik turizmni rivojlantirish nazariy-uslubiy va amaliy jihatlari bo‘yicha ilmiy-tadqiqot ishlarini olib borish dolzarb masala hisoblanadi.
title: The effectiveness of microwave ablation in the treatment of small renal tumours and correlation of the achieved ablation zone with the manufacturer's expected ablation zone
Creators: name: Doan, Emily
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Kidney
subject: CT
subject: Ablation procedures
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Renal cell carcinomas (RCC) are increasingly detected incidentally, at an earlier stage. 1,2 However, with increasing co-morbidities, minimally-invasive percutaneous therapies such as microwave ablation (MWA) are an important alternative for...
Occurrence of some rarely reported fish species in eastern Mediterranean marine caves
Creators: name: GEROVASILEIOU, Vasilis
name: GANIAS, Konstantinos
name: DAILIANIS, Thanos
name: VOULTSIADOU, Eleni
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: This study reports the occurrence of three rarely reported fish species of conservation interest, in marine caves of the Aegean Sea, updating the limited knowledge on their distribution and ecology. One of them, Grammonus ater, observed in the dark sector of a marine cave in the island of Crete (southern Aegean), is reported for the first time from the eastern Mediterranean. The other two are gobiid species found in a marine cave of Lesvos Island (northern Aegean): Corcyrogobius liechtensteini in cavities of the sponge Agelas oroides at the entrance of the cave and Thorogobius ephippiatus on the muddy bottom of the semidark and dark cave sectors.
The Bulgarian solitaire and the mathematics around it
Creators: name: Drensky, Vesselin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: Primary: 00A08, Secondary: 05A17, 11P81, 97A20

description: The Bulgarian solitaire is a mathematical card game played by one person. A pack of n cards is divided into several decks (or "piles"). Each move consists of the removing of one card from each deck and collecting the removed cards to form a new deck. The game ends when the same position occurs twice. It has turned out that when n=k(k+1)/2 is a triangular number, the game reaches the same stable configuration with size of the piles 1,2,...,k. The purpose of the paper is to tell the (quite amusing) story of the game and to discuss mathematical problems related with the Bulgarian solitaire. The paper is dedicated to the memory of Borislav Bojanov (1944-2009), a great mathematician, person, and friend, and one of the main protagonists in the story of the Bulgarian solitaire.
description: This is an invited talk at the 44-th Spring Conference of the Union of Bulgararian Mathematicians, SOK-Kamchia, April 2-6, 2015 (13 pages, contains 10 figures).
title: Serial multiparametric MRI in head and neck cancer treated with radical radiotherapy
Creators: name: Rumley, Christopher
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Head and neck
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: Radiation therapy / Oncology
subject: VMAT and Tomotherapy
subject: Cancer
subject: Outcomes
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Head and neck cancer is the 7th most common cancer in Australia, with 4,956 cases predicted in 2017. Curativetreatment of mucosal head and neck cancer typically consists of radical radiotherapy (with or without chemotherapy) or surgical resection...
(3991) Hector McAllister
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Parotids in RapidPlan Oropharynx Models: To Split or not to Split
Creators: name: O'Toole, Andrew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Head and neck
subject: CT
subject: Cone beam CT
subject: PET-CT
subject: Radiation therapy / Oncology
subject: VMAT and Tomotherapy
subject: Radiotherapy techniques

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Combined Chemo-Radiotherapy has become the preferred treatment option for patients with primary oropharyngeal cancer. It has been shown that with this treatment regime, the overall 2 year disease free survival is 82.4% with many good-risk patients...
Entanglement Holographic Mapping of Many-Body Localized System by Spectrum Bifurcation Renormalization Group
Creators: name: You, Yi-Zhuang
name: Qi, Xiao-Liang
name: Xu, Cenke
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce the spectrum bifurcation renormalization group (SBRG) as a generalization of the real-space renormalization group for the many-body localized (MBL) system without truncating the Hilbert space. Starting from a disordered many-body Hamiltonian in the full MBL phase, the SBRG flows to the MBL fixed-point Hamiltonian, and generates the local conserved quantities and the matrix product state representations for all eigenstates. The method is applicable to both spin and fermion models with arbitrary interaction strength on any lattice in all dimensions, as long as the models are in the MBL phase. In particular, we focus on the $1d$ interacting Majorana chain with strong disorder, and map out its phase diagram using the entanglement entropy. The SBRG flow also generates an entanglement holographic mapping, which duals the MBL state to a fragmented holographic space decorated with small blackholes.
description: 18 pages + 4 pages of appendixes and references, 20 figures
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
Creators: name: Ye, Rui
name: Selby, Christopher P.
name: Sancar, Aziz
name: Annayev, Yunus
name: Ozturk, Nuri
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The current consensus model for the circadian clock in mammals is based on a transcription-translation feedback loop. In this model, CRY and PER proteins repress their own transcription by suppressing the transactivator function of the CLOCK:BMAL1 heterodimer directly (physical model) and by facilitating post-translational modifications (chemical model). Most of the data for this model come from genetic and cell biological experiments. Here, we have purified all of the core clock proteins and performed in vitro and in vivo biochemical experiments to test the physical model. We find that CLOCK:BMAL1 binds to an E-box sequence in DNA and that CRY binds stably to the CLOCK:BMAL1:E-box ternary complex independently of PER. Both CRY and PER bind to CLOCK and BMAL1 off DNA but, in contrast to CRY, PER does not bind to the CLOCK:BMAL1:E-box complex. Unexpectedly, PER actually interferes with the binding of CRY to the CLOCK:BMAL1:E-box ternary complex. CRY likely destabilizes the CLOCK:BMAL1 heterodimer on DNA by a post-translational mechanism after binding to the complex. These findings support some aspects of the canonical model, but also suggest that some key features of the model need to be revised.
title: Tracing the ureters and VUJ on unenhanced CT KUB: does experience count?
Creators: name: Slater, Alexandra
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Diagnostic procedure
subject: CT
subject: Urinary Tract / Bladder
subject: Emergency
subject: Anatomy
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Urolithiasis is a common cause for presentation to the emergency department [1, 2] and for admission to hospital. It can cause significant morbidity and mortality [3]. Patients with renal colic receive an unenhanced, low-dose CT of the...
End-of-Life Care for Patients with Metastatic Renal Cell Carcinoma in the Era of Oral Anticancer Therapy
Creators: name: Baggett, C.D.
name: Jackson, B.E.
name: Zhang, T.
name: Scales, C.D., Jr.
name: Wilson, L.E.
name: Spees, L.P.
name: Gross, C.P.
name: Greiner, M.A.
name: Wheeler, S.B.
name: Dinan, M.A.
name: George, D.
name: Pritchard, J.E.
name: Dzimitrowicz, H.E.
name: Kaye, D.R.
name: Leapman, M.
Publisher: name: Lippincott Williams and Wilkins
Year: 2023

description: PURPOSE:New therapies including oral anticancer agents (OAAs) have improved outcomes for patients with metastatic renal cell carcinoma (mRCC). However, little is known about the quality of end-of-life (EOL) care and systemic therapy use at EOL in patients receiving OAAs or with mRCC.METHODS:We retrospectively analyzed EOL care for decedents with mRCC in two parallel cohorts: (1) patients (RCC diagnosed 2004-2015) from the University of North Carolina's Cancer Information and Population Health Resource (CIPHR) and (2) patients (diagnosed 2007-2015) from SEER-Medicare. We assessed hospice use in the last 30 days of life and existing measures of poor-quality EOL care: systemic therapy, hospital admission, intensive care unit admission, and > 1 ED visit in the last 30 days of life; hospice initiation in the last 3 days of life; and in-hospital death. Associations between OAA use, patient and provider characteristics, and EOL care were examined using multivariable logistic regression.RESULTS:We identified 410 decedents in the CIPHR cohort (53.4% received OAA) and 1,508 in SEER-Medicare (43.5% received OAA). Prior OAA use was associated with increased systemic therapy in the last 30 days of life in both cohorts (CIPHR: 26.5% v 11.0%; P <.001; SEER-Medicare: 23.4% v 11.7%; P <.001), increased in-hospital death in CIPHR, and increased hospice in the last 30 days in SEER-Medicare. Older patients were less likely to receive systemic therapy or be admitted in the last 30 days or die in hospital.CONCLUSION:Patients with mRCC who received OAAs and younger patients experienced more aggressive EOL care, suggesting opportunities to optimize high-quality EOL care in these groups.
Spontaneous Edge Accumulation of Spin Currents in Finite-Size Two-Dimensional Diffusive Spin-Orbit Coupled SFS Heterostructures
Creators: name: Alidoust, Mohammad
name: Halterman, Klaus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically study spin and charge currents through finite-size two-dimensional $s$-wave superconductor/uniform ferromagnet/s-wave superconductor (SFS) junctions with intrinsic spin-orbit interactions (ISOIs) using a quasiclassical approach. Considering experimentally realistic parameters, we demonstrate that the combination of spontaneously broken time-reversal symmetry and lack of inversion symmetry can result in spontaneously accumulated spin currents at the edges of finite-size two-dimensional magnetic SF hybrids. Due to the spontaneous edge spin accumulation, the corners of the F wire host the maximum spin current density. We further reveal that this type edge phenomena are robust and independent of either the actual type of ISOIs or exchange field orientation. Moreover, we study spin current-phase relations in these diffusive spin-orbit coupled SFS junctions. Our results unveil net spin currents, not accompanied by charge supercurrent, that spontaneously accumulate at the sample edges through a modulating superconducting phase difference. Finally, we discuss possible experimental implementations to observe these edge phenomena.
description: 11 pages, 6 figures
Cell Cycle-dependent Phosphorylation and Ubiquitination of a G Protein α Subunit
Creators: name: Clement, Sarah T.
name: Dohlman, Henrik G.
name: Torres, Matthew P.
name: Cappell, Steven D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A diverse array of external stimuli, including most hormones and neurotransmitters, bind to cell surface receptors that activate G proteins. Mating pheromones in yeast Saccharomyces cerevisiae activate G protein-coupled receptors and initiate events leading to cell cycle arrest in G1 phase. Here, we show that the Gα subunit (Gpa1) is phosphorylated and ubiquitinated in response to changes in the cell cycle. We systematically screened 109 gene deletion strains representing the non-essential yeast kinome and identified a single kinase gene, ELM1, as necessary and sufficient for Gpa1 phosphorylation. Elm1 is expressed in a cell cycle-dependent manner, primarily at S and G2/M. Accordingly, phosphorylation of Gpa1 in G2/M phase leads to polyubiquitination in G1 phase. These findings demonstrate that Gpa1 is dynamically regulated. More broadly, they reveal how G proteins can simultaneously regulate, and become regulated by, progression through the cell cycle.
(3992) Hector Sym
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Timescale of asteroid resurfacing by regolith convection resulting from the impact-induced global seismic shaking
Creators: name: Yamada, Tomoya M.
name: Ando, Kousuke
name: Morota, Tomokatsu
name: Katsuragi, Hiroaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: A model for the asteroid resurfacing by regolith convection is built to estimate its timescale. In the model, regolith convection is driven by the impact-induced global seismic shaking. The model consists of three steps: (i) intermittent impact of meteoroids, (ii) impact-induced global vibration (seismic shaking), and (iii) vibration-induced regolith convection. In order to assess the feasibility of the resurfacing process driven by regolith convection, we estimate the resurfacing timescale as a function of the size of a target asteroid. In the estimate, a set of parameter values is assumed on the basis of previous works. However, some of them (e.g., seismic quality factor $Q$, seismic efficiency $η$, and seismic frequency $f$) are very uncertain. Although these parameter values might depend on asteroid size, we employ the standard values to estimate the representative behavior. To clarify the parameter dependences, we develop an approximated scaling form for the resurfacing timescale. According to the estimated result, we find that the regolith-convection-based resurfacing timescale is shorter than the mean collisional lifetime in most of the parameter uncertainty ranges. These parameter ranges are within those reported by previous works for small asteroids. This means that the regolith convection can be a possible mechanism for the asteroid resurfacing process.
description: 14pages, 8figures
Characterization of an Interferon-stimulated Response Element (ISRE) in the Il23a Promoter
Creators: name: Matsuoka, Katsuyoshi
name: Sheikh, Shehzad Z.
name: Kobayashi, Taku
name: Onyiah, Joseph C.
name: Plevy, Scott E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We have demonstrated previously that IFN-γ plays a protective role in the initiation of chronic intestinal inflammation through attenuation of Toll-like receptor-mediated IL-23 induction in macrophages. Here, an interferon-stimulated response element (ISRE) is identified in a region of conserved nucleotide sequences in the Il23a promoter. This ISRE mediated, in part, Il23a promoter induction by LPS and inhibition of LPS-induced activity by IFN-γ. LPS and IFN-γ recruit interferon regulatory factors (IRFs) to the Il23a ISRE in murine bone marrow-derived macrophages (BMMs). Functionally, IRF-1 is a negative regulator of Il23a in LPS-stimulated BMMs. IRF-1−/− BMMs demonstrated enhanced LPS-induced Il23a expression compared with WT BMMs. Moreover, IRF-1 deficiency resulted in prolonged occupancy of RelA on the Il23a promoter. Consequently, IRF-1−/− mice were more susceptible to colonic injury by trinitrobenzenesulfonic acid, and IL-10/IRF-1 double-deficient (IL-10/IRF-1−/−) mice demonstrated more severe colonic inflammation compared with IL-10−/− mice. The severity of colitis in both models correlated with increased colonic IL-23. CD11b+ lamina propria mononuclear cells, comprising predominantly macrophages, were identified as the major source of IL-23 in colitis-prone mice. Basal and heat-killed Escherichia coli-stimulated levels of Il23a were increased in IL-10/IRF-1−/− compared with WT and IL-10−/− colonic CD11b+ lamina propria mononuclear cells. In conclusion, these experiments characterize IRF-ISRE interactions on the Il23a promoter, which have in vivo relevance as a homeostatic checkpoint in chronic intestinal inflammation.
title: Validation of Knowledge based planning for Rectal VMAT Radiotherapy – A plan comparison using Rapidplan
Creators: name: Wu, Kenny
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Gastrointestinal tract
subject: CT
subject: Comparative studies
subject: Radiation therapy / Oncology
subject: VMAT and Tomotherapy
subject: Radiotherapy techniques

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Volumetric modulated arc therapy (VMAT) has been utilized to treat rectal cancer patients since 2014 at Northern Sydney Cancer Centre (NSCC). VMAT is preferred due to superior plan quality in both target volume coverage and dose...
Characterization of the Oligomeric Structure of the Ca 2+ -activated Cl − Channel Ano1/TMEM16A
Creators: name: Yu, Kuai
name: Sheridan, John T.
name: Tarran, Robert
name: Worthington, Erin N.
name: Gabriel, Sherif E.
name: Hartzell, H. Criss
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Members of the Anoctamin (Ano)/TMEM16A family have recently been identified as essential subunits of the Ca2+-activated chloride channel (CaCC). For example, Ano1 is highly expressed in multiple tissues including airway epithelia, where it acts as an apical conduit for transepithelial Cl− secretion and helps regulate lung liquid homeostasis and mucus clearance. However, little is known about the oligomerization of this protein in the plasma membrane. Thus, utilizing mCherry- and eGFP-tagged Ano1 constructs, we conducted biochemical and Förster resonance energy transfer (FRET)-based experiments to determine the quaternary structure of Ano1. FRET and co-immunoprecipitation studies revealed that tagged Ano1 subunits directly associated before they reached the plasma membrane. This association was not altered by changes in cytosolic Ca2+, suggesting that this is a fixed interaction. To determine the oligomeric structure of Ano1, we performed chemical cross-linking, non-denaturing PAGE, and electromobility shift assays, which revealed that Ano1 exists as a dimer. These data are the first to probe the quaternary structure of Ano1. Understanding the oligomeric nature of Ano1 is an essential step in the development of therapeutic drugs that could be useful in the treatment of cystic fibrosis.
Claudin-2 Forms Homodimers and Is a Component of a High Molecular Weight Protein Complex
Creators: name: Anderson, James M.
name: Van Itallie, Christina M.
name: Mitic, Laura L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Tight junctions are multiprotein complexes that form the fundamental physiologic and anatomic barrier between epithelial and endothelial cells, yet little information is available about their molecular organization. To begin to understand how the transmembrane proteins of the tight junction are organized into multiprotein complexes, we used blue native-PAGE (BN-PAGE) and cross-linking techniques to identify complexes extracted from MDCK II cells and mouse liver. In nonionic detergent extracts from MDCK II cells, the tight junction integral membrane protein claudin-2 was preferentially isolated as a homodimer, whereas claudin-4 was monomeric. Analysis of the interactions between chimeras of claudin-2 and -4 are consistent with the transmembrane domains of claudin-2 being responsible for dimerization, and mutational analysis followed by cross-linking indicated that the second transmembrane domains were arranged in close proximity in homodimers. BN-PAGE of mouse liver membrane identified a relatively discrete high molecular weight complex containing at least claudin-1, claudin-2, and occludin; the difference in the protein complex sizes between cultured cells and tissues may reflect differences in tight junction protein or lipid composition or post-translational modifications. Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure.
A new genus and species of cirolanid isopod (Crustacea) from Zanzibar, Tanzania, western Indian Ocean
Creators: name: BRUCE, Niel L.
name: SVAVARSSON, Jörundur
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Baharilana gen. nov. is diagnosed and described. The genus contains two species and is distributed from the Red
 Sea to Tanzania, Western Indian Ocean from the shallow sub-tidal to a recorded depth of 1850 metres. The species included
 are the type species Baharilana richmondi sp. nov., which is here described and Baharilana bisulcata comb. nov. The genus
 is characterized by having a ventrally flat, pentagonal clypeus; pereopods 1–3 with the superior distal margin of the ischium
 moderately produced and setose, the merus anterodistal margin also moderately produced and setose but not overriding the
 propodus; paired flattened and articulating penial processes; pleopod 1 endopod narrow, half as wide as the sub-circular
 exopod; pleopod 2 appendix masculina sub-medially inserted, curving laterally around the ramus; and the uropod peduncle
 lateral margin with a row of plumose setae.
Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability
Creators: name: Wu, Susan C.
name: Zhang, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group protein that plays important roles in many biological processes including cellular differentiation, stem cell biology, and cancer development. Up-regulation of Ezh2 is observed in various human cancers consistent with its role in cell proliferation. Thus, understanding the regulation of Ezh2 may reveal how it contributes to the cellular proliferation process. Here, we demonstrate that Ezh2 can be regulated by the cyclin-dependent kinase, CDK1, which phosphorylates Ezh2 at threonines 345 and 487. Consistent with the cell cycle phase during which CDK1 exhibits peak activity, Ezh2 phosphorylation is enriched in cells arrested in mitosis when compared with S-phase. Phosphorylation of Thr-345 and Thr-487 promotes Ezh2 ubiquitination and subsequent degradation by the proteasome. Furthermore, expression of T345A/T487A confers a proliferative disadvantage when compared with cells expressing wild-type Ezh2, which suggests that phosphorylation of Ezh2 is important for cell proliferation. Collectively, these results establish a novel function for CDK1-mediated Ezh2 phosphorylation and provide a mechanism by which Ezh2 protein levels can be regulated in cells.
Additional file 1 of Communication of palliative care needs in discharge letters from hospice providers to primary care: a multisite sequential explanatory mixed methods study
Creators: name: Weetman, Katharine
name: Dale, Jeremy
name: Mitchell, Sarah J.
name: Ferguson, Claire
name: Finucane, Anne M.
name: Buckle, Peter
name: Arnold, Elizabeth
name: Clarke, Gemma
name: Karakitsiou, Despoina-Elvira
name: McConnell, Tracey
name: Sanyal, Nikhil
name: Schuberth, Anna
name: Tindle, Georgia
name: Perry, Rachel
name: Grewal, Bhajneek
name: Patynowska, Katarzyna A.
name: MacArtney, John I.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1. Data extraction form.
Deletion of Betaine-Homocysteine S -Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas
Creators: name: Mehedint, Mihai G.
name: Teng, Ya Wen
name: Zeisel, Steven H.
name: Garrow, Timothy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Betaine-homocysteine S-methyltransferase (BHMT) uses betaine to catalyze the conversion of homocysteine (Hcy) to methionine. There are common genetic polymorphisms in the BHMT gene in humans that can alter its enzymatic activity. We generated the first Bhmt−/− mouse to model the functional effects of mutations that result in reduced BHMT activity. Deletion of Bhmt resulted in a 6-fold increase (p < 0.01) in hepatic and an 8-fold increase (p < 0.01) in plasma total Hcy concentrations. Deletion of Bhmt resulted in a 43% reduction in hepatic S-adenosylmethionine (AdoMet) (p < 0.01) and a 3-fold increase in hepatic S-adenosylhomocysteine (AdoHcy) (p < 0.01) concentrations, resulting in a 75% reduction in methylation potential (AdoMet:AdoHcy) (p < 0.01). Bhmt−/− mice accumulated betaine in most tissues, including a 21-fold increase in the liver concentration compared with wild type (WT) (p < 0.01). These mice had lower concentrations of choline, phosphocholine, glycerophosphocholine, phosphatidylcholine, and sphingomyelin in several tissues. At 5 weeks of age, Bhmt−/− mice had 36% lower total hepatic phospholipid concentrations and a 6-fold increase in hepatic triacyglycerol concentrations compared with WT (p < 0.01), which was due to a decrease in the secretion of very low density lipoproteins. At 1 year of age, 64% of Bhmt−/− mice had visible hepatic tumors. Histopathological analysis revealed that Bhmt−/− mice developed hepatocellular carcinoma or carcinoma precursors. These results indicate that BHMT has an important role in Hcy, choline, and one-carbon homeostasis. A lack of Bhmt also affects susceptibility to fatty liver and hepatocellular carcinoma. We suggest that functional polymorphisms in BHMT that significantly reduce activity may have similar effects in humans.
title: Anatomical distribution of ureteric calculi in CT KUB studies: a single-centre audit
Creators: name: Slater, Alexandra
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Emergency
subject: Urinary Tract / Bladder
subject: Kidney
subject: CT
subject: Diagnostic procedure
subject: Obstruction / Occlusion

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The ureter is described to have three sites where it anatomically narrows and these are widely regarded as common sites for ureteric calculi to lodge ( Fig. 1 ): The pelviureteric junction (PUJ) The mid ureter where it crosses the iliac vessels, at...
Pressure-driven metal-insulator transition in BiFeO$_3$ from Dynamical Mean-Field Theory
Creators: name: Shorikov, A. O.
name: Lukoyanov, A. V.
name: Anisimov, V. I.
name: Savrasov, S. Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A metal-insulator transition (MIT) in BiFeO$_3$ under pressure was investigated by a method combining Generalized Gradient Corrected Local Density Approximation with Dynamical Mean-Field Theory (GGA+DMFT). Our paramagnetic calculations are found to be in agreement with experimental phase diagram: Magnetic and spectral properties of BiFeO3 at ambient and high pressures were calculated for three experimental crystal structures $R3c$, $Pbnm$ and $Pm\bar{3}m$. At ambient pressure in the $R3c$ phase, an insulating gap of 1.2 eV was obtained in good agreement with its experimental value. Both $R3c$ and $Pbnm$ phases have a metal-insulator transition that occurs simultaneously with a high-spin (HS) to low-spin (LS) transition. The critical pressure for the $Pbnm$ phase is 25-33 GPa that agrees well with the experimental observations. The high pressure and temperature $Pm\bar{3}m$ phase exhibits a metallic behavior observed experimentally as well as in our calculations in the whole range of considered pressures and undergoes to the LS state at 33 GPa where a $Pbnm$ to $Pm\bar{3}m$ transition is experimentally observed. The antiferromagnetic GGA+DMFT calculations carried out for the $Pbnm$ structure result in simultaneous MIT and HS-LS transitions at a critical pressure of 43 GPa in agreement with the experimental data.
(3993) Christina Milne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Short and long term evolution of a stellar disk around a massive black hole: The role of binaries, the cusp and stellar evolution
Creators: name: Mikhaloff, Diego N.
name: Perets, Hagai B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the dynamical evolution of a stellar disk orbiting a massive black hole. We explore the role of two-body relaxation, mass segregation, stellar evolution and binary heating in affecting the disk evolution, and consider the impact of the nuclear cluster structure and the stellar-disk mass-function. We use analytic arguments and numerical calculations, and apply them to study the evolution of a stellar disk (similar to that observed in the Galactic center; GC), both on the short (few Myr) and longer (100 Myr) evolutionary timescales. We find the dominant processes affecting the disk evolution are two-body relaxation and mass segregation where as binary heating have only a little contribution. Massive stars play a dominant role in kinematically heating low mass stars, and driving them to high eccentricities/inclinations. Multi-mass models with realistic mass-functions for the disk stars show the disk structure to be mass stratified, with the most massive stars residing in thinner structures. Stellar evolution plays an important role in decreasing the number of massive stars with time, thereby leading to slower relaxation, where the remnant compact objects of these stars are excited to higher eccentricities/inclinations. At these later evolutionary stages dynamical heating by the nuclear cluster plays a progressively more important role. We conclude that the high eccentricities of the disk-stars in the Galactic Center suggest that the disk formed with initially high eccentricities, or that collective or secular processes dominate the disk evolution. Finally, we find that the disk structure is expected to keep a thin structure even after 100 Myrs. It therefore suggests earlier disks now containing only older, lower mass stars might still be observed in the Galactic center, unless destroyed/smeared by other non-two-body relaxation processes.
description: Comments are welcome
title: Patterns of care and outcome of rectal cancer in the Illawarra Shoalhaven Local Health District
Creators: name: Rabbani, Romina
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Cancer
subject: Radiation therapy / Oncology
subject: Chemotherapy
subject: Surgery
subject: MR
subject: CT
subject: Oncology
subject: Gastrointestinal tract
subject: Outcomes
subject: Multidisciplinary cancer care

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Evaluate patterns of care in the Illawarra Shoalhaven Local Health District (ISHLD) over an 8 year period. To describe patterns of recurrence and survival outcomes in patients with rectal...
Additional file 1 of The score after 10 years of registration of systematic review protocols
Creators: name: van der Braak, Kim
name: Ghannad, Mona
name: Orelio, Claudia
name: Heus, Pauline
name: Damen, Johanna A. A.
name: Spijker, René
name: Robinson, Karen
name: Lund, Hans
name: Hooft, Lotty
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Search string
A new species of Paranerilla (Polychaeta: Nerillidae) from Northeast Greenland Waters, Arctic Ocean
Creators: name: WORSAAE, Katrine
name: MØBJERG KRISTENSEN, Reinhardt
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Paranerilla cilioscutata sp. nov. is described from high arctic waters, off Northeast Greenland. It was found in
 muddy sediments at depths of 32 to 590 m between 77°09'N and 82°11'N and between 8°40.42'W and 30°24'W in
 Independence Fjord and the Greenland Sea. The new species expands the distribution of Nerillidae into the Arctic. It is
 compared with Paranerilla limicola which is the only other species of the genus. New material of P. limicola was collected
 at the type locality in the Gullmar Fjord, Sweden (58°16'N, 11°28'E). Both species were studied with light microscopy (alive
 and preserved) and scanning electron microscopy. Both have seven segments with compound chaetae and the characteristic
 prostomium of Paranerilla, with two lateral horns and a dense covering of cilia. The new species differs from P. limicola by
 a much denser dorsal ciliation and lack of prostomial ciliated sensory fields. The dorsal ciliation of P. cilioscutata sp. nov.,
 totally covers the prostomium and segment 1, and is seen as ciliary plates on segments 2-6 (versus partly ciliated prostomium
 and segment 1, and narrow double or single ciliary bands on segments 2-6 in P. limicola). The present studies of P. limicola
 revealed two new groups of sensory cilia (absent in P. cilioscutata sp. nov.) located on the anterior and posterior part of the
 prostomium, respectively.
Is the Higgs Mechanism of Fermion Mass Generation a Fact? A Yukawa-less First-Two-Generation Model
Creators: name: Ghosh, Diptimoy
name: Gupta, Rick Sandeepan
name: Perez, Gilad
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is now established that the major source of electroweak symmetry breaking (EWSB) is due to the observed Higgs particle. However, whether the Higgs mechanism is responsible for the generation of all the fermion masses, in particular, the fermions of the first two generations, is an open question. In this letter we present a construction where the light fermion masses are generated through a secondary, subdominant and sequestered source of EWSB. This fits well with the approximate U(2) global symmetry of the observed structure of the flavor sector. We first realize the above idea using a calculable two Higgs doublet model. We then show that the first two generation masses could come from technicolor dynamics, while the third generation fermions, as well as the electroweak gauge bosons get their masses dominantly from the Higgs mechanism. We also discuss how the small CKM mixing between the first two generations and the third generation, and soft mixing between the sequestered EWSB components arise in this setup. A typical prediction of this scenario is a significant reduction of the couplings of the observed Higgs boson to the first two generation of fermions.
description: Version to be published in PLB
title: Comparison of Contrast-Enhanced Magnetic Resonance Angiography and Carotid Ultrasound findings in Stroke/TIA patients
Creators: name: Ng, Andrew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Cardiovascular system
subject: Anatomy
subject: Vascular
subject: MR-Angiography
subject: Ultrasound
subject: Diagnostic procedure
subject: Comparative studies
subject: Embolism / Thrombosis
subject: Ischaemia / Infarction
subject: Obstruction / Occlusion

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Background: Carotid stenosis is implicated in up to 20% of strokes.[1] Thereforeit is important to evaluate extra-cranial vasculature post acute cerebral ischaemia. This is done in order to attempt to idetify the mechanism of the stroke/transient...
A new species of scale-worm (Polychaeta: Polynoidae), Levensteiniella iris sp. nov., from the Rainbow and Lucky Strike vent fields (Mid-Atlantic Ridge)
Creators: name: HOURDEZ, Stéphane
name: DESBRUYÈRES, Daniel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: A new species of scale-worm belonging to the sub-family Macellicephalinae, Levensteiniella iris sp. nov., is
 described. It was collected on the Mid-Atlantic Ridge, on the Lucky Strike and Rainbow vent sites, associated to the mussel
 Bathymodiolus azoricus on very low flow hydrothermal vents.
title: Development and Validation of Knowledge based planning for oropharyngeal VMAT radiotherapy
Creators: name: Wu, Kenny
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Radiotherapy techniques
subject: VMAT and Tomotherapy
subject: Radiation therapy / Oncology
subject: Comparative studies
subject: CT
subject: Head and neck

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Synchronous Chemo-Radiotherapy has become the treatment of choice for patients diagnosed with primary oropharyngeal cancer. It has been shown that with this treatment regime, the overall 2 year disease free survival is 82.4% with many good-risk...
Five-list-coloring graphs on surfaces II. A linear bound for critical graphs in a disk
Creators: name: Postle, Luke
name: Thomas, Robin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Let $G$ be a plane graph with outer cycle $C$ and let $(L(v):v\in V(G))$ be a family of sets such that $|L(v)|\ge 5$ for every $v\in V(G)$. By an $L$-coloring of a subgraph $J$ of $G$ we mean a (proper) coloring $ϕ$ of $J$ such that $ϕ(v)\in L(v)$ for every vertex $v$ of $J$. We prove a conjecture of Dvorak et al. that if $H$ is a minimal subgraph of $G$ such that $C$ is a subgraph of $H$ and every $L$-coloring of $C$ that extends to an $L$-coloring of $H$ also extends to an $L$-coloring of $G$, then $|V(H)|\le 19|V(C)|$. This is a lemma that plays an important role in subsequent papers, because it motivates the study of graphs embedded in surfaces that satisfy an isoperimetric inequality suggested by this result. Such study turned out to be quite profitable for the subject of list coloring graphs on surfaces.
description: 25 pages, 2 figures
title: Patterns of Outcome Study over 20 years in metastatic Squamous cell carcinoma of Parotid –The Royal Adelaide Hospital Experience
Creators: name: Chen, Anni
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Radiation therapy / Oncology
subject: CT
subject: Head and neck
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Metastatic parotid cutaneous squamous cell carcinoma is the most common parotid gland malignancy in New Zealand and Australia. [1] Postoperative radiotherapy (RT) improves outcomes for patients with advanced cutaneous squamous cell carcinoma of the...