cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Aerodynamic properties of urban areas derived from analysis of surface form.
Creators: name: Grimmond, C. S. B.
name: Oke, Timothy R.
Publisher: name: American Meteorological Society
Year: 2011

description: Several methods to determine the aerodynamic characteristics of a site through analysis of its surface form (morphometry) are considered in relation to cities. The measures discussed include zero-plane displacement length (zd), roughness length (z0), depth of the roughness sublayer, and aerodynamic conductance. A sensitivity analysis is conducted on seven formulas to estimate zd and nine to estimate z0, covering a wide range of probable urban roughness densities. Geographic information systems developed for 11 sites in 7 North American cities are used to characterize their morphometry—the height, shape, three-dimensional area, and spatial distribution of their roughness elements (buildings and trees). Most of the sites are in residential suburbs, but one is industrial and two are near city centers. This descriptive survey of urban geometric form is used, together with the morphometric formulas, to derive the apparent aerodynamic characteristics of the sites. The resulting estimates of zd and z0 are compared with values obtained from analysis of wind and turbulence observations. The latter are obtained from a survey of approximately 60 field studies and 14 laboratory studies of real and scale model cities. Despite the comprehensive nature of the survey, very few studies are found to be acceptable and their scatter is large, hence they do not provide a standard against which to test the morphometric algorithms. Further, the data show only weak relations between measured zd and z0 and roughness density. The relative merits of morphometric and wind-based estimates of aerodynamic parameters are discussed. Recommendations are made concerning the choice of method to estimate zd and z0 in urban areas and their most likely magnitude. Copyright 1999 American Meteorological Society (AMS). Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108, as revised by P.L. 94-553) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a web site or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. Additional details are provided in the AMS Copyright Policy, available on the AMS Web site located at (http://www.ametsoc.org/) or from the AMS at 617-227-2425 or copyright@ametsoc.org.
An Investigation in-to the Possible Effects of Physical Features of Nesting Beaches on the Nest Site Beach Selection by Chelonia mydas (the green turtle) and Caretta caretta ( the loggerhead turtle)
Creators: name: McDermott, Mike
Publisher: name: figshare
Year: 2013
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: An investigation in to possible effects of physical beach parameters on the magnitude and success of nesting effort in the marine turtles Chelonia mydas, (green turtle), and Caretta caretta, (loggerhead turtle).The physical parameters measured were: beach length, beach width, beach slope, beach digability, beach waterlogging, sand grain size. Parameters describing marine turtle nesting were: number of activities, number of nests, nesting density, percentage emergence success and proportion of nests. It is known that marine turtles nest on a variety of sandy substrates but there have been very few investigations as to the factors responsible, (if any), for the selection of the nesting beaches. Data were collected during the 1997 nesting season and analysed by the use of multivariate statistics, (multiple regression). Results showed that some of the measures of beach selection significantly correlated, (both positive and negative), with some of the physical measurements, (nesting density correlated well with beach orientation in C caretta and with beach digability in C mydas). Results allowed conclusions to be drawn as to which factors had greatest effect on nesting beach selection and suggested areas of future possible research. Due to interseasonal nesting differences the actual predictions made from the regression analyses may vary from year to year. There may be other unmeasured physical parameters that exert an effect. There is scope for further study in to the effect that these and other physical parameters may be having in clutch viability and hatching success.
ASALARICHILIK SANOATINING MAMLAKATIMIZNING MINTAQAVIY RIVOJLANISHIGA QO'SHAYOTGAN HISSASI
Creators: name: Muxitdinov, Xudayar
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada asalari sanoatining mamlakatimizning mintaqaviy rivojlanishiga qo'shayotgan hissasi tahlil qilinadi. Asalarichilikning iqtisodiy va ekologik foydalari, qishloq xo'jaligi bilan bog'liq bo'lgan ijobiy ta'siri va mintaqaviy iqtisodiyotni rivojlantirishdagi roli ko'rib chiqiladi. Shuningdek, bu sohaning rivojlanishiga ta'sir etuvchi omillar va kelajak istiqbollari ham muhokama qilinadi.
Assessment of applicability domain for multivariate counter-propagation artificial neural network predictive models by minimum Euclidean distance space analysis: A case study
Creators: name: Minovski, Nikola
name: Špela Župerl
name: Drgan, Viktor
name: Novič, Marjana
Publisher: name: figshare
Year: 2013
Subjects: Cheminformatics
Theoretical Computer Science

description: Alongside the validation, the concept of applicability domain (AD) is probably one of the most important
aspects which determine the quality as well as reliability of the established quantitative structure–activity relationship (QSAR) models. To date, a variety of approaches for AD estimation have been devised which can be applied to particular type of QSAR models and their practical utilization is extensively elaborated in the literature. The present study introduces a novel, simple, and effective distance-based method for estimation of the AD in case of developed and validated predictive counter-propagation artificial neural network (CP ANN) models through a proficient exploitation of the Euclidean distance (ED) metric in the
structure-representation vector space. The performance of the method was evaluated and explained in a case study by using a pre-built and validated CP ANN model for prediction of the transport activity of the transmembrane protein bilitranslocase for a diverse set of compounds. The method was tested on two more datasets in order to confirm its performance for evaluation of the applicability domain in CP ANN models. The chemical compounds determined as potential outliers, i.e., outside of the CP ANN model AD, were confirmed in a comparative AD assessment by using the leverage approach. Moreover, the method offers a graphical depiction of the AD for fast and simple determination of the extreme points.
Terugblik Wikipedian-in-Residence en mogelijkheden met Wikipedia in de toekomst - Congres Collectie Nederland in Context, Utrecht, 08-10-2014
Creators: name: Janssen, Olaf
name: de Haan, Tim
Publisher: name: Zenodo
Year: 2024
Subjects: Koninklijke Bibliotheek
Olaf Janssen
Tim de Haan
Nationaal Archief
National Archives of the Netherlands
GLAM
Wikipedian in Residence
Wikipedia
GLAMwiki
KB, national library of the Netherlands

description: De Koninklijke Bibliotheek en het Nationaal Archief zijn de eerste Nederlandse erfgoedinstellingen die een Wikipedian-in-Residence in huis hebben gehaald. Het afgelopen jaar heeft deze huiswikipediaan een brug gebouwd tussen de rijke collecties van de KB en het NA en het hergebruik van deze content op Wikipedia.

Na een korte inleiding op de wereld achter Wikipedia laten Tim en Olaf zien hoe het project de kennis, vaardigheden en bewustwording over ‘Wiki en erfgoed’ binnen en buiten de instellingsmuren heeft vergroot en hoe de content van beide instellingen wereldwijd breder toegankelijk en herbruikbaar is gemaakt. Aan het einde blikken ze vooruit hoe de KB en het NA ook in 2015 met Wikipedia kunnen blijven samenwerken.

Olaf Janssen is Open Data coördinator bij de Koninklijke Bibliotheek in Den Haag. Ook was hij namens de KB coördinator van het eerste Wikipedian-in-Residence project van Nederland. Hij was nauw betrokken bij de beginjaren van Europeana en was een van de oprichters van The European Library.

Tim de Haan werkt aan de digitale dienstverlening van het Nationaal Archief in Den Haag. Ook is hij namens het NA coördinator van het eerste Wikipedian-in-Residence project van Nederland. In de afgelopen jaren is hij nauw betrokken geweest bij het beschikbaar stellen van collectiedata als open data www.gahetna.nl/opendata.

Presentatie tijdens het Congres Collectie Nederland in Context, Utrecht, 08-10-2014 - http://www.siob.nl/thema-s/programma-congres-collectie-nederland-in-context-8-oktober-2014/item2772
European elections and digital policy: German party positions
Creators: name: Güttel, Licinia
Publisher: name: Zenodo
Year: 2024

description: From the 6th to the 9th of June 2024, the tenth European Parliament elections will take place. To what extent are German parties addressing digital policy? This blog post analyses the election programmes of the parties represented in the Bundestag and examines where and in what contexts digital issues appear. From the SPD’s call for a “Digital Union” to the AfD’s populist rhetoric around the rejection of a digital euro, parties prioritise different aspects of digital policy. What does this mean for Europe’s digital future, especially in light of a potential shift to the right in the Parliament?
Heat storage in urban areas: Local-scale observations and evaluation of a simple model.
Creators: name: Grimmond, C. S. B.
name: Oke, Timothy R.
Publisher: name: American Meteorological Society
Year: 2011

description: The flux density of sensible heat to or from storage in the physical mass of the city is determined for seven cities (Chicago, Illinois; Los Angeles, California; Mexico City, Distrito Federal; Miami, Florida; Sacramento, California; Tucson, Arizona; and Vancouver, British Columbia) in North America across a 30° latitudinal range. These cities have a variety of synoptic-scale climates and surface cover and structural morphologies. In all cases the “measured” storage heat flux is determined as the energy balance residual from direct observations of net all-wave radiation, and sensible and latent heat fluxes conducted using the same radiometer and eddy correlation techniques. Databases describing the surface characteristics around each site are developed from analysis of aerial photography and field surveys. Results indicate that storage heat flux is a significant component of the surface energy balance at all sites and is greatest at downtown and light industrial sites. Hysteresis behavior, of varying degrees, is seen at all locations. A simple objective hysteresis model (OHM), which calculates storage heat flux as a function of net all-wave radiation and the surface properties of the site, is found to perform well in the mean for most cases, with the notable exception of Tucson; but considerable scatter is observed at some sites. Some of this is attributed to the moisture, wind, and synoptic controls at each of the sites, and to hour-to-hour variability in the convective fluxes that the OHM does not simulate. Averaging over 2 to 3 h may be a more appropriate way to use the model. Caution should be used when employing the OHM in windy environments. Copyright 1999 American Meteorological Society (AMS). Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108, as revised by P.L. 94-553) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a web site or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. Additional details are provided in the AMS Copyright Policy, available on the AMS Web site located at (http://www.ametsoc.org/) or from the AMS at 617-227-2425 or copyright@ametsoc.org.
Cluster-based molecular docking study for in silico identification of novel 6-fluoroquinolones as potential inhibitors against Mycobacterium tuberculosis
Creators: name: Minovski, Nikola
name: Perdih, Andrej
name: Novič, Marjana
name: Solmajer, Tom
Publisher: name: figshare
Year: 2013
Subjects: subject: Theoretical Computer Science
subject: Crystallography
subject: Computational Biology
subject: Cheminformatics
subject: Microbiology
subject: FOS: Biological sciences

description: A classical protein sequence alignment and homology modeling strategy were used for building three Mycobacterium tuberculosis-DNA gyrase protein models using the available topoII-DNA-6FQ crystal structure complexes originating from different organisms. The recently determined M. tuberculosis-DNA gyrase apoprotein structures and topoII-DNA-6FQ complexes were used for defining the 6-fluoroquinolones (6-FQs) binding pockets. The quality of the generated models was initially validated by docking of the cocrystallized ligands into their binding site, and subsequently by quantitative evaluation of their discriminatory performances (identification of active/inactive 6-FQs) for a set of 145 6-FQs with known biological activity values. The M. tuberculosis-DNA gyrase model with the highest estimated discriminatory power was selected and used afterwards in an additional molecular docking experiment on a mixed combinatorial set of 427 drug-like 6-FQ analogs for which the biological activity values were predicted using a prebuilt counter-propagation artificial neural network model. A novel three-level Boolean-based [T/F (true/false)] clustering algorithm was used to assess the generated binding poses: Level 1 (geometry properties assessment), Level 2 (score-based clustering and selection of the (T)-signed highly scored Level 1 poses), and Level 3 (activity-based clustering and selection of the most “active” (T)-signed Level 2 hits). The frequency analysis of occurrence of the fragments attached at R1 and R7 position of the (T)-signed 6-FQs selected in Level 3 revealed several novel attractive fragments and confirmed some previous findings. We believe that this methodology could be successfully used in establishing novel possible structure-activity relationship recommendations in the 6-FQs optimization, which could be of great importance in the current antimycobacterial hit-to-lead processes.
Dionisia Pérez Losada. Nueva y curiosa relación: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Dionisia Pérez Losada. Nueva y curiosa relación: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
In Silico Assessment of Adverse Effects of a Large Set of 6-Fluoroquinol- ones Obtained from a Study of Tuberculosis Chemotherapy
Creators: name: Tušar, Marjan
name: Minovski, Nikola
name: Fjodorova, Natalja
name: Novič, Marjana
Publisher: name: figshare
Year: 2013
Subjects: subject: Theoretical Computer Science
subject: Cheminformatics
subject: Toxicology
subject: Microbiology
subject: FOS: Biological sciences

description: Among the different chemotherapeutic classes available today, the 6-fluoroquinolone (6-FQ) antibacterials are still one of the most effective cures in fighting tuberculosis (TB). Nowadays, the development of novel 6-FQs for treatment of TB mainly depends on understanding how the structural modifications of the main quinolone scaffold at specific positions affect the anti-mycobacterial activity. Alongside the structure-activity relationship (SAR) studies of the 6-FQ antibacterials, which can be considered as a golden rule in the development of novel active antitubercular 6-FQs, the structure side-effects relationship (SSER) of these drugs must be also taken into account. In the present study we focus on a proficient implementation of the existing knowledge-based expert systems for design of novel 6-FQ antibacterials with possible enhanced biological activity against Mycobaterium tuberculosis as well as lower toxicity. Following the SAR in silico studies of the quinolone antibacterials against M. tuberculosis performed in our laboratory, a large set of 6-FQs was selected. Several new 6-FQ derivatives were proposed as drug candidates for further research and development. The 6- FQs identified as potentially effective against M. tuberculosis were subjected to an additional SSER study for prediction of their toxicological profile. The assessment of structurally-driven adverse effects which might hamper the potential of new drug candidates is mandatory for an effective drug design. We applied publicly available knowledge-based (expert) systems and Quantitative Structure-Activity Relationship (QSAR) models in order to prepare a priority list of active compounds. A preferred order of drug candidates was obtained, so that the less harmful candidates were identified for further testing. TOXTREE expert system as well as some QSAR models developed in the framework of EC funded project CAESAR were used to assess toxicity. CAESAR models were developed according to the OECD principles for the validation of QSAR and they turn to be appropriate tools for in silico tests regarding five different toxicity endpoints. Those endpoints with high relevance for REACH are: bioconcentration factor, skin sensitization, carcinogenicity, mutagenicity, and developmental toxicity. We used the above-mentioned freely available models to select a set of less harmful active 6-FQs as candidates for clinical studies.
QSTR modelling of the acute toxicity of pharmaceuticals to fish
Creators: name: Tuğcu, Gülçin
name: Saçan, Melek Türker
name: Vračko, Marjan
name: Novič, Marjana
name: Minovski, Nikola
Publisher: name: figshare
Year: 2013
Subjects: Toxicology
Cheminformatics
Marine Biology
Theoretical Computer Science

description: Extensive use of pharmaceuticals as human and veterinary medication raises concerns for their adverse effects on non-target organisms. The purpose of this study was to employ multiple linear regression (MLR) to predict the toxicities of a diverse set of pharmaceuticals to fish. The descriptor pool consisted of about 1500 descriptors calculated using Dragon 5.4, Spartan 06 and Codessa 2.2 software. Descriptor selection was made by the heuristic method available in Codessa 2.2. The data set was divided into training and test sets using Kohonen networks. The training set contained approximately 65% of the compounds of the full data set (99 compounds). The training set model contained eight descriptors from all dimensions, all of which were obtained from Dragon 5.4. The statistical parameters of the model for the training set are R(2 )= 0.664, F = 13.588, and R(cv)(2) (LOO) = 0.542 while it achieves R(2 )= 0.605 for the test set. The training, test and external sets have no response outliers considering the standardized residual greater than three. The external validation of the model was made with a set of pharmaceuticals obtained from several databases. The R(pred)(2) is 0.777, reflecting a relatively good predictive power for the external set.
Dionisia Pérez Losada. Nueva y curiosa relación: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
The effectiveness of mobile preschool (Northern Territory) in improving school readiness for very remote indigenous children
Creators: name: Nutton, Georgina
Publisher: name: Charles Darwin University
Year: 2013

description: This study provided the first systematic data regarding efficacy of preschool programs for very remote Northern Territory Indigenous children including baselines for socio-demographic and health characteristics. The study quantified the effects of program availability, attendance and preschool program quality on follow-up measures of development and school readiness using the Australian Early Development Index. When controlling for mothers smoking during pregnancy, children attending more than 80 days of mobile preschool were 4.9 times more likely to not be developmentally vulnerable than children attending less than 80 days, (95% CI: 1.72 - 13.95). The results inform future improvements in children’s developmental outcomes by improving children’s attendance and professional learning for preschools educators to achieve high quality curriculum, pedagogy and assessment practices matched to the needs of children and families in disadvantaged and complex learning environments.
Investigation of 6-fluoroquinolones activity against Mycobacterium tuberculosis using theoretical molecular descriptors: a case study
Creators: name: Minovski, Nikola
name: Mazzarello, Aneta Jezierska
name: Vračko, Marjan
name: Šolmajer, Tom
Publisher: name: figshare
Year: 2013
Subjects: subject: Theoretical Computer Science
subject: Cheminformatics
subject: Microbiology
subject: FOS: Biological sciences

description: A quantitative structure-activity relationship (QSAR) study on a set of 66 structurally-similar 6-fluoroquinolones was performed using a large pool of theoretical molecular descriptors. Ab initio geometry optimizations were carried out to reproduce the geometrical and electronic structure parameters. The resulting molecular structures were confirmed to be minima via harmonic frequency calculations. Obtained atomic charges, HOMO and LUMO energies, orbital electron densities, dipole moment, energy and many other properties served as quantum-chemical descriptors. A multiple linear regression (MLR) technique was applied to generate a linear model for predicting the biological activity, Minimal Inhibitory Concentration (MIC), treated as negative decade logarithm, (pMIC). The heuristic method was used to optimize the model parameters and select the most significant descriptors. The model was tested internally using the CV LOO procedure on the training set and validated against the external validation set. The result (Q 2 ext = 0.7393), which was obtained on an external, previously excluded validation data set, shows the predictive performances of this model (R 2 tr = 0.7416, Q 2 tr = 0.6613) in establishing (Q)SAR of 6-fluoroquinolones. This validated model could be proficiently used to design new 6-fluoroquinolones with possible higher activity.
A construção de modelos educativos na Antiguidade: pais e mães das Histórias de Heródoto
Creators: name: Soares, Carmen Isabel Leal
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2008

description: Com base em episódios que retratam situações formativas de relacionamento entre pais e filhos, busca-se uma avaliação de tópicos essenciais ao tema da educação nas Histórias. O presente estudo assenta na resposta às seguintes questões: os modelos paternos e maternos são sempre diferentes ou convergem em determinados valores e/ou atitudes? O Autor apresenta apenas exempla construtivos ou também ilustra tipos a rejeitar? Os comportamentos têm uma relação directa com a origem cultural dos indivíduos? Ou seja, ser Grego ou Bárbaro determina retratos de mães e pais forçosamente distintos?
description: Ágora. Estudos Clássicos em Debate, n.º 10 (2008)
Are Anomaly Detection Models Suitable for Code Smell Detection? A Preliminary Study
Creators: name: De Stefano, Manuel
name: Pecorelli, Fabiano
name: Lomio, Francesco
name: lenarduzzi, valentina
name: Palomba, Fabio
name: De Lucia, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Code Smells are symptoms of poor design and implementation choices. Researchers spent a great effort studying them for a long time, as they are known causes of complex code maintainability, change, and fault proneness. Many (semi) automatic approaches to detect and correct code smells have been proposed in recent years, both heuristic-based and machine learning-based. While the former present some issues (threshold dependent, lack of agreement, subjective interpretation) that are thought to be solved by the latter, ML-based approaches suffer from shallow performances, particularly a very high false-positive rate. Past studies explained this given the unbalanced nature of the problem: code smells are indeed a needle in the haystack of a software system. Hence, inspired by this assertion, in this paper we explore a different perspective on code smell detection, as if they were anomaly code components. Exploiting this idea, in this paper, we explore the possibility of using anomaly detection models to detect code smells in software systems. The achieved results showed models scoring a very high recall and a very low precision. To comprehend why anomaly detection outcomes are limited, this study investigates the role and significance given by the code metrics. As a result, we believe that the code metrics exploited to distinguish between smelly and non-smelly code components are insufficient.
El matón de Andalucía: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Mercenarismo grego e tradição militar helenística: uma análise das questões bélicas no mediterrâneo do séc. III A.C.
Creators: name: Sant’Anna, Henrique Modanez De
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2008

description: Este artigo apresenta o mercenarismo grego (misthotiké) como elemento difusor da tradição militar helenística, formada no cenário pós-guerra do Peloponeso, expressa nos exércitos taticamente integrados e estendida tanto nos reinos sucessores de Alexandre, o Grande quanto na reforma do exército cartaginês, sob a forma de uma escola tática que vincula as tropas mercenárias gregas de fins do século V a.C. a Pirro e Xantipo, no séc. III a.C.
description: Ágora. Estudos Clássicos em Debate, n.º 10 (2008)
Quantitative structure-activity relationships (QSARs) using the novel marine algal toxicity data of phenols
Creators: name: M. Doğa Ertürk
name: Saçan, Melek Türker
name: Novič, Marjana
name: Minovski, Nikola
Publisher: name: figshare
Year: 2013
Subjects: Toxicology
Cheminformatics
Marine Biology
Theoretical Computer Science

description: The present study reports for the first time in its entirety the toxicity of 30 phenolic compounds to
marine alga Dunaliella tertiolecta. Toxicity of polar narcotics and respiratory uncouplers was strongly
correlated to hydrophobicity as described by the logarithm of the octanol/water partition coefficient (LogP). Compounds expected to act by more reactive mechanisms, particularly hydroquinones, were shown to have toxicity in excess of that predicted by Log P. A quality quantitative structure–activity relationship (QSAR) was obtained with Log P and a 2D autocorrelation descriptor weighted by atomic polarizability (MATS3p) only after the removal of hydroquinones from the data set. In an attempt to model the whole data set including hydroquinones, 3D descriptors were included in the modeling process and three quality QSARs were developed using multiple linear regression (MLR). One of the most significant results of the present study was the superior performance of the consensus MLR model, obtained by averaging the predictions from each individual linear model, which provided excellent prediction accuracy for the test set (Q2test=0.94). The four-parameter Counter Propagation Artificial Neural Network (CP ANN) model, which was constructed using four out of six descriptors that appeared in the linear models, also provided
an excellent external predictivity (Q2test=0.93).
The proposed algal QSARs were further tested in their predictivity using an external set comprising
toxicity data of 44 chemicals on freshwater alga Pseudokirchneriella subcapitata. The two-parameter global model employing a 3D descriptor (Mor24m) and a charge-related descriptor (Cortho) not only had high external predictivity (Q2ext=0.74), but it also had excellent external data set coverage (%97).
Subordinate uncertainty and manager fairness enactment: A pilot study to test the validity of the manipulation materials that will be used in the focal experimental study
Creators: name: Nishioka, Midori
name: Bobocel, D. Ramona
name: Beck, James W.
Publisher: name: OSF Registries
Year: 2020
Subjects: subject: Industrial and Organizational Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is a pilot study in which we test the validity of our manipulation materials for a future experimental study. The experimental study will involve manipulating subordinate uncertainty and job performance through vignettes describing hypothetical employees. This pilot study will test whether the vignettes manipulate the intended constructs in the expected direction.
Os labirintos da cidade: Marcial em Roma
Creators: name: Torrão, João Manuel Nunes
name: Andrade, António Manuel Lopes
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2008

description: Marcial conhecia como ninguém a cidade de Roma e serve de guia aos leitores da actualidade através das ruas labirínticas da Urbe. Essa cidade apresentava características específicas que dificultavam a circulação quer de pessoas quer de viaturas, apesar dos esforços de alguns políticos para irem melhorando o tecido urbano.
description: Ágora. Estudos Clássicos em Debate, n.º 10 (2008)
MINTAQA ASALARICHILIKNI SAMARADORLIKNI OSHIRISHNI KLASTERLASH YO'LLARI
Creators: name: Muxitdinov, Xudayar
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola mintaqa asalarichiligida klasterlash metodini qo'llash orqali iqtisodiy, geografik va biologik samaradorlikni oshirishning mohiyati va ilmiy asoslarini o'rganishga bag'ishlangan. Klasterlash texnologiyasi asalarichilikda qo'llanilganda, asalarichilik faoliyatining samaradorligini oshirish, mahsulot sifatini yaxshilash, ishlab chiqarish xarajatlarini kamaytirish va asalarichilikni barqaror rivojlantirish imkoniyatlarini yaratadi. Ushbu maqolada klasterlashning asosiy afzalliklari, ilmiy jihatlari, iqtisodiy samaradorlikka ta'siri va geografik hamda biologik omillar bilan aloqadorligi tahlil qilinadi. Shu bilan birga, ushbu metodni amalga oshirishning mintaqaviy xususiyatlari va qiyinchiliklari haqida ham muhim ma'lumotlar keltiriladi.
Des arts de prêcher à la rhétorique sacrée: la prédication au Portugal pendant la Renaissance
Creators: name: Pereira, Belmiro Fernandes
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2008

description: Nous avons cherché à interpréter l’évolution de la parénétique portugaise durant les XVe et XVIe siècles, d’après l’action des prêcheurs de la Cour, des reportationes vernaculaires des chroniqueurs royaux, des sermons et des orationes de Martinho de Viana, Gil Vicente, Garcia de Resende e Fr. Heitor Pinto. La compa-raison avec les arts de prêcher permet de montrer: premièrement, comment la tradition du sermo modernus a su résister à la force conformatrice de la rhétorique classique; deuxièmement, comment les rhétoriques sacrées, en conséquence de l’action de contre-réforme, en sont venues à utiliser les langages de l’humanisme — les spolia Aegyptii mentionnés dans les textes normatifs des jésuites; troisièmement, à quel niveau les rhétoriques tridentines procèdent à une récupération partielle du modèle médiéval.
description: Ágora. Estudos Clássicos em Debate, n.º 10 (2008)
El matón de Andalucía: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
BioExcel Webinar #64: BioExcel HPC Workflows: predictive power and its applications in pharmacology
Creators: name: Hospital, Adam
name: Battistini, Federica
name: Miłosz Wieczór
Publisher: name: Zenodo
Year: 2022
Subjects: webinar

description: One of the main goals of the BioExcel CoE is the design and development of biomolecular simulation workflows combining the BioExcel key applications (GROMACS, HADDOCK, PMX) to tackle exciting scientific projects. Over the last few years, particular focus has been placed in workflows with predictive power, combining HPC and AI. Developed workflows have been tested in different use cases with an important link to the pharmacological field, demonstrating the predictive power of the BioExcel key applications assisted by HPC workflows. Three different workflows/studies designed as a collaborative project effort from the CoE partners (NBD, IRB, BSC, KTH, MPG) will be briefly presented in this webinar: * High-throughput prediction of the impact of genetic variability on drug sensitivity and resistance patterns for clinically relevant EGFR mutations from atomistic simulations.
 * Large-scale SARS-CoV2 mutation analysis, including a study on the evolutionary path and host-selection mechanism of SARS-CoV-2.
 * DNAffinity: A Machine-Learning approach to predict DNA Binding affinities of Transcription Factors.
Mindfulness for Prejudice Reduction
Creators: name: Ash, Tory
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social and Behavioral Sciences

description: There are pervasive, consistent, and consequential racial disparities in educational outcomes (Quintana & Mahgoub, 2016). These disparities can be explained, in part, by teachers’ implicit biases (Kumar et al., 2015). Given that disparate educational outcomes contribute to widespread racial inequities (Olneck, 2005), there is a need to address the mechanisms responsible for racial bias in education. Devine and colleagues (2012) posit that in order to reduce bias, individuals must be aware of their biases, be concerned about the consequences of their biases, and learn strategies that they can enact to actively reduce their biases. Theoretically, mindfulness-based practices are well-suited to address the three necessary components for prejudice reduction. Specifically, mindfulness practices can be deployed to facilitate the detection of bias (Lueke & Gibson, 2015), cultivate concern for others (Luberto et al., 2014), and leveraged as a prejudice reduction strategy (Yang, 2020). In support of this, prior research on pre-service teachers found that training in mindfulness practices led to lasting reductions in implicit race bias (Hirschberg et al., 2019). However, prior research has exclusively relied on Implicit Association Task (Greenwald et al., 1998), which has been found to be unrelated to discriminatory teaching practices (Quinn et al., 2020). Therefore, the proposed research will examine the relationship between mindfulness and teacher bias using ecologically valid, behavioral, and consequential measures. As such, this study represents a novel application of contemplative science and has the potential to add to the literature on the documented success of mindfulness programming for both teachers and students.
El matón de Andalucía: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Where are we? : individual geographic location using two different sources of postal code information in BC
Creators: name: McGrail, Kimberlyn M.
name: Fung, Patrick Wong
Publisher: name: Centre for Health Services and Policy Research (CHSPR)
Year: 2014

description: The purpose of this project was to compare, on an age-specific basis, the postal codes from these two sources as recorded in 1999. They have been compared at three levels: six-digit postal code, local health area (LHA) and Health Region (HR). The results should provide researchers with information on the reliability of geographic location based on the different sources and therefore about potential difficulties with regional analyses. The results will also provide an empirical basis for the decision about which source of postal codes ought to be used for research purposes.
A justificação do tiranicídio na Écloga Gérion de Lucas Pereira
Creators: name: Fernandes, José Sílvio Moreira
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2008

description: Lucas Pereira escreveu uma écloga dramática para ser representada nas cerimónias de encerramento do ano escolar no Colégio de Coimbra, no ano de 1612. A matéria escolhida foi o décimo trabalho de Hércules contra o triforme Gérion, o monstro que a tradição situava no sudoeste da Península Ibérica. Nesta adaptação do mito, o autor opta por centrar na Lusitânia a acção tiranicida de Hércules que bate o adversário em combate singular numa colina perto de Coimbra. Pretendemos demons-trar que uma das intencionalidades da peça reside na apresentação de uma teoria de legitimação do tiranicídio, praticado contra o tirano usurpador, cuja aparência tripla podia representar os inimigos de Portugal, no início de séc. XVII: leões (Castela), leopardos (Inglaterra) e Pigmeus (aliados internos da União Ibérica).
description: Ágora. Estudos Clássicos em Debate, n.º 10 (2008)
Chemometrical Exploration of Combinatorially Generated Drug-like Space of 6-fluoroquinolone Analogs: A QSAR Study
Creators: name: Minovski, Nikola
name: Šolmajer, Tom
Publisher: name: figshare
Year: 2013
Subjects: subject: Theoretical Computer Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cheminformatics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A classical virtual combinatorial chemistry approach (CombiChem) was applied for combinatorial generation of 5590 novel structurally-similar 6-fluoroquinolone analogs by using a virtual synthetic pathway with selected primary (43) and secondary amines (130). The obtained virtual combinatorial library was filtered using an in-house developed set of cheminformatics drug-likeness filters with pre-integrated Boolean options (TRUE/FALSE) for compounds reduc-tion/selection. The retained number (304) of fluoroquinolone analogs (with TRUE outcome) defines the drug-like che-mical space (CombiData). Quantitative structure-activity relationships (QSAR) study on these 304 virtually generated 6-fluoroquinolone analogs with unknown activity values was performed using a pre-built five-parameter multiple linear regression (MLR) model developed on a set of compounds with experimentally determined activity values (R tr = 0.8417, R tr-cv = 0.7884). The obtained activity values for the unknown compounds together with the model results were used to define the applicability domain (AD). The obtained AD offers a good graphical representation and establishment of structure-activity relationships (SAR) which could be used for design of new 6-fluoroquinolones with possible better activity.
title: Identification of a Spatio-Temporal Temperature Model for Laser Metal Deposition
Creators: name: Kahl, Matthias
name: Schramm, Sebastian
name: Neumann, Max
name: Kroll, Andreas
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: spatio-temporal dynamics
subject: system identification
subject: laser metal deposition
subject: additive manufacturing
subject: 620
subject: Metallabscheidung
subject: Dynamik
subject: Laser
subject: Rapid Prototyping

description: Gefördert durch den Publikationsfonds der Universität Kassel
Coplas nuevas para cantar los aficionados: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Les études latines au Brésil
Creators: name: Tuffani, Eduardo
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2007

description: Nous cherchons à montrer l’importance qu’a eu l’enseignement du latin dans la période coloniale au Brésil, en donnant une attention particulière au rôle de la Compagnie de Jésus. Ainsi, nous analysons le long processus de réorganisation de l’enseignement secondaire et de la création des études supérieures. Nous arborons une époque allant de la fin du secondaire de tradition littéraire jusqu’à la fondation des premiers cours de Lettres et de Philosophie. Nous dressons donc un bilan des études latines de 1940 à 1970 au Brésil, période de grande vitalité pour celles-ci, tout en traitant la Loi Capanema de 1942 et l’ancienne Loi de Directives et Bases de l’Education Nationale. La rétrospective se clôt par le descriptif des activités jusqu’en 1996, compte tenu de la conjoncture à l’occasion de la nouvelle Loi de Directives et Bases.
description: Ágora. Estudos Clássicos em Debate, n.º 9 (2007)
Coplas nuevas para cantar los aficionados: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Does perceived control change in the face of a consequential chance event?
Creators: name: Johnson, Tim
Publisher: name: OSF Registries
Year: 2020
Subjects: subject: Business
subject: Organizational Behavior and Theory
subject: Public Affairs, Public Policy and Public Administration
subject: Economics
subject: Political Science
subject: FOS: Political science
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: The degree to which individuals perceive their lives as the result of individual volition, versus chance, predicts a wide range of economic, social, and health outcomes. But what causes perceptions of control in the first place? Here we propose to test the intuitive hypothesis that exposure to a life-changing, stochastic event shifts perceptions of control. Using data from two nationally representative surveys (the National Longitudinal Study of Youth and the Health Retirement Survey), we examine how numbers assigned in the Vietnam-Era Selective Service Lotteries affected individuals’ perceptions of personal control over their lives on the whole, as well as salient categories of life outcomes including their personal finances, social well-being, and health.