cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bivariate Random Effects Meta-Analysis of Diagnostic Studies Using Generalized Linear Mixed Models
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Bivariate random effect models are currently one of the main methods recommended to synthesize diagnostic test accuracy studies. However, only the logit-transformation on sensitivity and specificity has been previously considered in the literature. In this paper, we consider a bivariate generalized linear mixed model to jointly model the sensitivities and specificities, and discuss the estimation of the summary receiver operating characteristic curve (ROC) and the area under the ROC curve (AUC). As the special cases of this model, we discuss the commonly used logit, probit and complementary log-log transformations. To evaluate the impact of misspecification of the link functions on the estimation, we present two case studies and a set of simulation studies. Our study suggests that point estimation of the median sensitivity and specificity, and AUC is relatively robust to the misspecification of the link functions. However, the misspecification of link functions has a noticeable impact on the standard error estimation and the 95% confidence interval coverage, which emphasizes the importance of choosing an appropriate link function to make statistical inference.
The Impact of a Novel Computer-Based Decision Aid on Shared Decision-Making for Colorectal Cancer Screening: A Randomized Trial (Running head: SDM for CRC Screening)
Creators: name: Emmons, Karen
name: Robinson, Patricia A.
name: Pignone, Michael
name: Evans, Stephen
name: Peters, Ellen
name: Glick, Julie T.
name: Heeren, Timothy C.
name: Chaisson, Christine
name: Schroy, Paul C.
name: Prout, Marianne
name: Davidson, Peter
name: Mylvanaman, Shamini
name: Lydotes, Maria A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Eliciting patients’ preferences within a framework of shared decision-making (SDM) has been advocated as a strategy for increasing colorectal cancer (CRC) screening adherence. Our objective was to assess the effectiveness of a novel decision aid on SDM in the primary care setting.
Estimating the Cost of No-Shows and Evaluating the Effects of Mitigation Strategies
Creators: name: Pignone, Michael
name: Murr, Michael
name: Sandler, Robert S.
name: Denton, Brian T.
name: Chermak, David
name: Berg, Bjorn P.
name: Woodall, Jonathan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To measure the cost of non-attendance (“no-shows”) and benefit of overbooking and interventions to reduce no-shows for an outpatient endoscopy suite.
A Generalized Write Channel Model for Bit-Patterned Media Recording
Creators: name: Naseri, Sima
name: Yazdani, Somaie
name: Razeghi, Behrooz
name: Hodtani, Ghosheh Abed
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we propose a generalized write channel model for bit-patterned media recording by considering all sources of errors causing some extra disturbances during write process, in addition to data dependent write synchronization errors. We investigate information-theoretic bounds for this new model according to various input distributions and also compare it numerically to the last proposed model.
description: Accepted for publication in the IEEE International Symposium on Information Theory and its Applications (ISITA 2014), Melbourne, Australia, Oct. 2014
Relationship between Physicians’ Uncertainty about Clinical Assessments and Patient-Centered Recommendations for Colorectal Cancer Screening in the Elderly
Creators: name: Lewis, Carmen L.
name: Pignone, Michael P.
name: Pathman, Donald E.
name: Dalton, Alexandra F.
name: Esserman, Denise
name: Golin, Carol E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The goal of this study was to examine associations between physicians’ clinical assessments, their certainty in these assessments, and the likelihood of a patient-centered recommendation about colorectal cancer (CRC) screening in the elderly.
Изучение возможных биохимических и морфологических маркеров феномена "no-reflow" в эксперименте
Creators: name: Калинин Р.Е.
name: Пшенников Александр Сергеевич
name: Деев Р.В.
Publisher: name: Клиническая и экспериментальная хирургия
Year: 2018
Subjects: ФЕНОМЕН "NO-REFLOW"
РЕПЕРФУЗИЯ
ОКИСЛИТЕЛЬНЫЙ СТРЕСС
КАРБОНИЛЬНЫЕ ПРОИЗВОДНЫЕ ПРОТЕИНОВ
КАТЕПСИНЫ
ЭНДОТЕЛИЙ
"NO-REFLOW" PHENOMENON
REPERFUSION
OXIDATIVE STRESS
CARBONYL DERIVATIVES OF PROTEINS
CATHEPSINS
ENDOTHELIUM

description: Цель работы изучить взаимосвязь карбонильных производных протеинов и повреждение эндотелия сосудов как потенциальных предикторов развития феномена «no-reflow» в условиях экспериментального моделирования реперфузии. Методы. Исследование выполнено на лабораторных животных (крысах линии Wistar) в соответствии с этическими нормами, изложенными в Конвенции по защите позвоночных животных, используемых для экспериментальных и других научных целей (Страсбург, 1986) и приказе Минздрава России № 267 от 19.06.2003 «Об утверждении правил лабораторной практики». Модель реперфузии создавали путем пережатия брюшного отдела аорты с последующим кондиционированием. Определяли активность лизосомальных цистеиновых протеиназ, уровень окислительно-модифицированных белков в плазме, в гомогенатах стенки сосудов и в интактной стенке, выделенной дистальнее операционного вмешательства. Трансмиссионная электронная микроскопия проведена на просвечивающем электронном микроскопе «Libra 120» с автоматическим сканированием изображений (Carl Zeiss, Германия). Статистический анализ результатов исследования проведен, согласно руководству по медицинской статистике с применением современных методов виртуального математического анализа и использованием программы «Statistica 10.0». Для оценки статистической значимости различий независимых выборок использовали критерий Манна-Уитни (U-тест). Результаты. В ходе проведенного исследования доказано, что при экспериментальном моделировании реперфузии окислительный стресс развивается с 1-х по 7-е сутки в плазме и с 3-х по 7-е сутки в сосудистой стенке. Окислительный стресс в сосудистой стенке характеризуется истощением резервно-адаптационного потенциала и преобладанием вторичных маркеров на фоне активации катепсинов В и L на 3-й и 5-е сутки, что нашло подтверждение в поражении структур интимы. Вывод. Достоверное увеличение вторичных метаболитов окислительного стресса в стенке сосуда вызвало повреждение эндотелиальных клеток, что может определять важное структурное звено патогенеза феномена «no-reflow».
Priorities for Generative AI Regulation in the UK: CREATe response to the Digital Regulation Cooperation Forum (DRCF)
Creators: name: Eben, Magali
name: Erickson, Kristofer
name: Kretschmer, Martin
name: Cifrodelli, Gabriele
name: Li, Zihao
name: Luca, Stefan
name: Meletti, Bartolomeo
name: Schlesinger, Philip
Publisher: name: Zenodo
Year: 2023

description: In July 2023 the UK Digital Regulation Cooperation Forum (DRCF) issued a request for comment on the status of generative AI and priority regulatory concerns. The DRCF is comprised of four of the UK’s major regulators: the Competition and Markets Authority (CMA), the Financial Conduct Authority (FCA), the Information Commissioner’s Office (ICO) and Ofcom. As a research centre with a focus on technology regulation and evidence-based policy making, CREATe is undertaking research that addresses the specific questions raised by the DRCF. As we lay out in our response, the challenges posed by generative AI will be complex, imposing a need for regulators to actively engage with evidence on these dynamic and multifaceted effects. This response addresses key questions raised by the DRCF. Notably, the anticipated direction of travel of innovation of GenAI in the near term, an assessment of what citizens and consumers are currently doing with GenAI, how regulated services are making use of GenAI, what gaps in regulation currently exist, and how future regulation can be balanced with competition, innovation, consumer wellbeing and people’s rights and freedoms. We suggest that addressing these issues requires an interdisciplinary approach. Regulatory responses will need to be cross-domain, adaptable, and scalable to confront these multi-faceted challenges. Research which takes a holistic view incorporating various legal and policy domains can contribute to supporting cross-domain regulatory initiatives.
Additional file 3 of Genomic and phenotypic landscapes of X-linked hereditary hearing loss in the Chinese population
Creators: name: Feng, Haifeng
name: Huang, Shasha
name: Ma, Ying
name: Yang, Jinyuan
name: Chen, Yijin
name: Wang, Guojian
name: Han, Mingyu
name: Kang, Dongyang
name: Zhang, Xin
name: Dai, Pu
name: Yuan, Yongyi
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Table S3. Overview of pathogenic variants identified in SMPX gene.
A Technique to Derive Improved Proper Motions for Kepler Objects of Interest
Creators: name: Benedict, G. Fritz
name: Tanner, Angelle M.
name: Cargile, Phillip A.
name: Ciardi, David R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We outline an approach yielding proper motions with higher precision than exists in present catalogs for a sample of stars in the Kepler field. To increase proper motion precision we combine first moment centroids of Kepler pixel data from a single Season with existing catalog positions and proper motions. We use this astrometry to produce improved reduced proper motion diagrams, analogous to a Hertzsprung-Russell diagram, for stars identified as Kepler Objects of Interest. The more precise the relative proper motions, the better the discrimination between stellar luminosity classes. With UCAC4 and PPMXL epoch 2000 positions (and proper motions from those catalogs as quasi-bayesian priors) astrometry for a single test Channel (21) and Season (0) spanning two years yields proper motions with an average per-coordinate proper motion error of 1.0 millisecond of arc per year, over a factor of three better than existing catalogs. We apply a mapping between a reduced proper motion diagram and an HR diagram, both constructed using HST parallaxes and proper motions, to estimate Kepler Object of Interest K-band absolute magnitudes. The techniques discussed apply to any future small-field astrometry as well as the rest of the Kepler field.
description: Accepted to The Astronomical Journal 15 August 2014
Computing total energies in complex materials using charge self-consistent DFT+DMFT
Creators: name: Park, Hyowon
name: Millis, Andrew J.
name: Marianetti, Chris A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have formulated and implemented a fully charge-self-consistent density functional theory plus dynamical mean field theory methodology which enables an efficient calculation of the total energy of realistic correlated electron systems. The density functional portion of the calculation uses a plane wave basis set within the projector augmented wave method enabling study of systems with large, complex unit cells. The dynamical mean field portion of the calculation is formulated using maximally localized Wannier functions, enabling a convenient implementation which is independent of the basis set used in the density functional portion of the calculation. The importance of using a correct double counting term is demonstrated. A generalized form of the standard double counting correction, which we refer to as the $U^\prime$ form, is described in detail and used. For comparison the density functional plus U method is implemented within the same framework including the generalized double counting. The formalism is validated via a calculation of the metal-insulator and structural phase diagrams of the rare-earth nickelate perovskites as functions of applied pressure and A-site rare-earth ions. The calculated density functional plus dynamical mean field results are found to be consistent with experiment. The density functional plus U method is shown to grossly overestimate the tendency for bond-disproportionation and insulating behavior.
description: 19 pages, 13 figures
Ultrasound-guided three-dimensional needle steering in biological tissue with curved surfaces
Creators: name: Abayazid, Momen
name: Alterovitz, Ron
name: Moreira, Pedro
name: Shahriari, Navid
name: Misra, Sarthak
name: Patil, Sachin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In this paper, we present a system capable of automatically steering a bevel-tipped flexible needle under ultrasound guidance toward a physical target while avoiding a physical obstacle embedded in gelatin phantoms and biological tissue with curved surfaces. An ultrasound pre-operative scan is performed for three-dimensional (3D) target localization and shape reconstruction. A controller based on implicit force control is developed to align the transducer with curved surfaces to assure the maximum contact area, and thus obtain an image of sufficient quality. We experimentally investigate the effect of needle insertion system parameters such as insertion speed, needle diameter and bevel angle on target motion to adjust the parameters that minimize the target motion during insertion. A fast sampling-based path planner is used to compute and periodically update a feasible path to the target that avoids obstacles. We present experimental results for target reconstruction and needle insertion procedures in gelatin-based phantoms and biological tissue. Mean targeting errors of 1.46 ± 0.37 mm, 1.29 ± 0.29 mm and 1.82 ± 0.58 mm are obtained for phantoms with inclined, curved and combined (inclined and curved) surfaces, respectively, for insertion distance of 86–103 mm. The achieved targeting errors suggest that our approach is sufficient for targeting lesions of 3 mm radius that can be detected using clinical ultrasound imaging systems.
Expectations and experiences of practising veterinarians throughout an 8-week mindfulness-based stress reduction programme
Creators: name: Djokovic, A
name: Cooper-Thomas, HD
name: Gardner, D
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: To explore practising veterinarians’ expectations of an 8-week mindfulness training programme, their perceived barriers to participating in the programme, their experiences of the programme and the extent to which they continued to engage in mindfulness practices following training. Participants were 10 companion animal veterinarians practising in Auckland, New Zealand. All took part in an 8-week mindfulness-based training programme. A longitudinal qualitative design was used: data were collected by structured interviews prior to the programme, upon completion of the programme and 3 months after completion. Data were analysed using thematic analysis to identify recurring themes, or patterns, within the data. Before commencing the programme, participants generally thought mindfulness training would provide some benefits for wellbeing but were otherwise not clear on what to expect. The main concerns about taking part were time constraints and apprehensions about potentially having to share personal information, and consequently how they might be perceived by other participants. On completion of the training programme, the opportunity to share experiences within the group with the support of a trained facilitator was reported as the most valuable aspect of the programme, rather than the mindfulness practices themselves. At the 3-month follow-up, participants reported they had learnt some useful techniques for managing stressful thoughts and situations, but despite the perceived benefits, few were still practicing mindfulness techniques. Training in mindfulness practices may have some value for helping practicing veterinarians manage their wellbeing, but it is not a complete solution in itself. Participants reported that the greatest benefits came from facilitated peer support.
Additional file 1 of Prevalence, risk factors, and characterisation of extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) in horses entering an equine hospital and description of longitudinal excretion
Creators: name: Eskola, Katarina
name: Aimo-Koivisto, Elina
name: Heikinheimo, Annamari
name: Mykkänen, Anna
name: Hautajärvi, Tiina
name: Grönthal, Thomas
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1. Antimicrobial resistance genes of the extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) isolates in the prevalence study
Additional file 1 of Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021
Creators: name: Lyimo, Eric
name: Fougeroux, Cyrielle
name: Malabeja, Anangisye
name: Mbwana, Joyce
name: Hayuma, Paul M.
name: Liheluka, Edwin
name: Turner, Louise
name: Gesase, Samwel
name: Lavstsen, Thomas
name: Lusingu, John P. A.
name: Minja, Daniel T. R.
name: Wang, Christian W.
Publisher: name: figshare
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Baseline characteristics of the study populations from before the COVID-19 pandemic.
Organic nanofibers embedding stimuli-responsive threaded molecular components
Creators: name: Fasano, Vito
name: Baroncini, Massimo
name: Moffa, Maria
name: Iandolo, Donata
name: Camposeo, Andrea
name: Credi, Alberto
name: Pisignano, Dario
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: While most of the studies on molecular machines have been performed in solution, interfacing these supramolecular systems with solid-state nanostructures and materials is very important in view of their utilization in sensing components working by chemical and photonic actuation. Host polymeric materials, and particularly polymer nanofibers, enable the manipulation of the functional molecules constituting molecular machines, and provide a way to induce and control the supramolecular organization. Here, we present electrospun nanocomposites embedding a self-assembling rotaxane-type system that is responsive to both optical (UV-visible light) and chemical (acid/base) stimuli. The system includes a molecular axle comprised of a dibenzylammonium recognition site and two azobenzene end groups, and a dibenzo[24]crown-8 molecular ring. The dethreading and rethreading of the molecular components in nanofibers induced by exposure to base and acid vapors, as well as the photoisomerization of the azobenzene end groups, occur in a similar manner to what observed in solution. Importantly, however, the nanoscale mechanical function following external chemical stimuli induces a measurable variation of the macroscopic mechanical properties of nanofibers aligned in arrays, whose Young's modulus is significantly enhanced upon dethreading of the axles from the rings. These composite nanosystems show therefore great potential for application in chemical sensors, photonic actuators and environmentally responsive materials.
description: 39 pages, 16 figures
Towards a reliability assessment of the Cn2 and wind speed vertical profiles retrieved from GeMS
Creators: name: Neichel, Benoit
name: Masciadri, Elena
name: Guesalaga, Andrés R.
name: Lascaux, Franck
name: Béchet, Clémentine
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The advent of a new generation of Adaptive Optics systems called Wide Field AO (WFAO) mark the beginning of a new era. By using multiple Guide Stars (GSs), either Laser Guide Stars (LGSs) or Natural Guide Stars (NGSs), WFAO significantly increases the field of view of the AO-corrected images, and the fraction of the sky that can benefit from such correction. Different typologies of WFAO have been studied over the past years. They all require multiple GSs to perform a tomographic analysis of the atmospheric turbulence. One of the fundamental aspects of the new WFAO systems is the knowledge of the spatio-temporal distribution of the turbulence above the telescope. One way to get to this information is to use the telemetry data provided by the WFAO system itself. Indeed, it has been demonstrated that WFAO systems allows one to derive the Cn2 and wind profile in the main turbulence layers (see e.g. Cortes et al. 2012). This method has the evident advantage to provide information on the turbulence stratification that effectively affects the AO system, property more difficultly respected by independently vertical profilers. In this paper, we compare the wind speeds profiles of GeMS with those predicted by a non-hydrostatical mesoscale atmospherical model (Meso-NH). It has been proved (Masciadri et al., 2013), indeed, that this model is able to provide reliable wind speed profiles on the whole troposphere and stratosphere (up to 20-25 km) above top-level astronomical sites. Correlation with measurements revealed to be very satisfactory when the model performances are analyzed from a statistical point of view as well on individual nights. Such a system appears therefore as an interesting reference to be used to quantify the GeMS wind speed profiles reliability.
description: 10 pages, 5 figures - Proceedings of the SPIE, Adaptive Optics Systems IV, 9148-236
Inhalant withdrawal as a clinically significant feature of inhalant dependence disorder
Creators: name: Perron, Brian E.
name: Jarman, Christopher N.
name: Vaughn, Michael G.
name: Howard, Matthew O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Inhalant use is the intentional inhalation of vapors from commercial products or specific chemical agents for the purpose of achieving intoxication. Inhalants are among the most common and pernicious forms of substance use and the least studied of the major drugs. Diagnosis of inhalant dependence, according to the DSM-IV [1] excludes inhalant withdrawal symptoms, as expert opinion has suggested that an inhalant withdrawal syndrome is neither common nor clinically significant. This article draws from multiple sources of data to suggest that withdrawal symptoms can be part of inhalant dependence and are clinically significant. This hypothesis needs rigorous evaluation to ensure the diagnostic validity of inhalant use disorders.
Modulated trapping of interacting bosons in one dimension
Creators: name: Quinn, Eoin
name: Haque, Masudul
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate the response of harmonically confined bosons with contact interactions (trapped Lieb-Liniger gas) to modulations of the trapping strength. We explain the structure of resonances at a series of driving frequencies, where size oscillations and energy grow exponentially. For strong interactions (Tonks-Girardeau gas), we show the effect of resonant driving on the bosonic momentum distribution. The treatment is `exact' for zero and infinite interactions, where the dynamics is captured by a single-variable ordinary differential equation. For finite interactions the system is no longer exactly solvable. For weak interactions, we show how interactions modify the resonant behavior for weak and strong driving, using a variational approximation which adds interactions to the single-variable description in a controlled way.
description: 9 pages, 8 figures
Additional file 2 of Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021
Creators: name: Lyimo, Eric
name: Fougeroux, Cyrielle
name: Malabeja, Anangisye
name: Mbwana, Joyce
name: Hayuma, Paul M.
name: Liheluka, Edwin
name: Turner, Louise
name: Gesase, Samwel
name: Lavstsen, Thomas
name: Lusingu, John P. A.
name: Minja, Daniel T. R.
name: Wang, Christian W.
Publisher: name: figshare
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2 The number of SARS-CoV-2 seropositive and negative infants in Kwamasimba and Mkokola villages based on age in months.
Development of hard water sensor using Fluorescence Resonance Energy Transfer
Creators: name: Dey, Dibyendu
name: Bhattacharjee, D.
name: Chakraborty, S.
name: Hussain, Syed Arshad
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A method is presented for the sensing of water hardness by determining the concentration of calcium and magnesium in water, based on Fluorescence resonance energy transfer (FRET) process. The principle of the proposed sensor is based on the change of FRET efficiency between two laser dyes Acriflavine (Acf) and Rhodamine B (RhB) in presence of permanent hard water components (CaCl2 and MgCl2). Nanodimensional clay platelet laponite was used to enhance the efficiency of the sensor.
description: 27 pages, 5 figures. arXiv admin note: substantial text overlap with arXiv:1408.6556
Elevating Bergenline Avenue: connecting rooftops to embrace Latin culture
Creators: name: Ruiz, Anthony
Publisher: name: No Publisher Supplied
Year: 2023

description: Bergenline Avenue is a commercial road that intersects the municipalities of North Bergen, Guttenberg, West New York, and Union City within Hudson County. Of the four, the three latter municipalities are considered to be amongst the most densely populated cities in the United States. This overabundance of people is amplified by the attractions that the road brings. Bergenline Avenue serves as a central location where people can access a multitude of storefronts that range from restaurants, retail stores, to medical offices all within a block’s radius. This convenience allows for consumers to visit the bustling hub as a destination that can cater to any need. Beyond the provision of services, the road also serves as a symbol of over a century’s worth of urbanization that reflects changes in transportation, demographics, and industry within the region. Despite this historical significance and appeal, a visiting person’s experience is diminished due to a lack of available space that is caused by overcrowded sidewalks, heavy traffic with consistent honking, and a lack of pedestrian friendly infrastructure in seating and vegetation for shading. As an urbanized city, this exploration will allow for public spaces to be reimagined and created amidst heavy development. This design exploration will involve a skyward expansion that takes advantage of the existing density of buildings found along the road. By utilizing currently unused rooftop spaces, publicly accessible spaces will be created that celebrates the existing population’s culture and the history of the region. This new rooftop experience will create a key destination that will enhance the experience of visitors, embrace Latin culture, create unique viewsheds, and give back to the community.
Targeting cognitive-affective risk mechanisms in stress-precipitated alcohol dependence: An integrated, biopsychosocial model of automaticity, allostasis, and addiction
Creators: name: Garland, Eric L.
name: Boettiger, Charlotte A.
name: Howard, Matthew O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: This paper proposes a novel hypothetical model integrating formerly discrete theories of stress appraisal, neurobiological allostasis, automatic cognitive processing, and addictive behavior to elucidate how alcohol misuse and dependence are maintained and re-activated by stress. We outline a risk chain in which psychosocial stress initiates physiological arousal, perseverative cognition, and negative affect that, in turn, triggers automatized schema to compel alcohol consumption. This implicit cognitive process then leads to attentional biases toward alcohol, subjective experiences of craving, paradoxical increases in arousal and alcohol-related cognitions due to urge suppression, and palliative coping through drinking. When palliative coping relieves distress, it results in negative reinforcement conditioning that perpetuates the cycle by further sensitizing the system to future stressful encounters. This model has implications for development and implementation of innovative behavioral interventions (such as mindfulness training) that disrupt cognitive-affective mechanisms underpinning stress-precipitated dependence on alcohol.
African swine fever in wild boar
Creators: name: Schulz, Katja
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 630 Agriculture

description: African swine fever (ASF) has been a concern for 100 years. However, after the disease reached Georgia in 2007 and spread rapidly, researchers worldwide became even more interested. The role of wild boar in the current epidemic is prominent. The epidemiology of ASF in wild boar was therefore examined in detail and existing knowledge gaps closed. The enclosed participatory studies with hunters helped to identify starting points whose inclusion could help to improve ASF surveillance, make it more effective and thus increase the chance of its successful application.
Challenging diagnosis and successful treatment of localised Mycobacterium avium subsp. hominissuis glossitis in a dog on long-term immunomodulatory therapy
Creators: name: Häußler, TC
name: Thom, N
name: Prenger-Berninghoff, E
name: Köhler, K
name: Barth, SA
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A 3-year-old, intact female mixed-breed dog, weighing 7 kg, was presented with generalised swelling of the tongue, leading to impaired deglutition and episodes of dyspnoea. From the age of 2 years, the dog had been under immunosuppressive therapy due to atopic dermatitis. Multiple nodular lesions at the apex of the tongue were noted as well as mandibular and retropharyngeal lymph node enlargement. Serum biochemistry results showed inflammatory changes. The results of several biopsies taken over 7 months indicated persistent pyogranulomatous and necrotising glossitis despite ongoing antimicrobial treatment, first with amoxicillin/clavulanic acid and then pradofloxacin. No foreign material, acid-fast bacteria or fungal hyphae were detected throughout. The final diagnosis of Mycobacterium avium subsp. hominissuis (Mah) was reached after PCR and bacterial culture were carried out on the third biopsy sample. Therapy was initiated with rifampicin, clarithromycin and doxycycline, leading to complete remission of the lesions. Severe chronic pyogranulomatous and necrotising glossitis associated with infection by Mah. This report describes challenges in the diagnosis and therapy of a localised Mah infection in an iatrogenically immunocompromised dog. Successful treatment was only achieved with a specific combination of antibiotics administered long-term. AF: Acid-fast; ALP: Alkaline phosphatase; CT: Computed tomography; MAC: Mycobacterium avium complex; Mah: Mycobacterium avium subsp. hominissuis
Additional file 1 of Genomic and phenotypic landscapes of X-linked hereditary hearing loss in the Chinese population
Creators: name: Feng, Haifeng
name: Huang, Shasha
name: Ma, Ying
name: Yang, Jinyuan
name: Chen, Yijin
name: Wang, Guojian
name: Han, Mingyu
name: Kang, Dongyang
name: Zhang, Xin
name: Dai, Pu
name: Yuan, Yongyi
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. The 227 HL-related genes included in the predefined panel.
Ephrin–Eph signaling as a potential therapeutic target for the treatment of myocardial infarction
Creators: name: Griffin, William F.
name: Kent, Susan D.
name: O’Neal, Wesley T.
name: Chen, Jin
name: Willis, Monte S.
name: Virag, Jitka A.I.
name: Dries-Devlin, Jessica L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Although numerous strategies have been developed to reduce the initial ischemic insult and cellular injury that occurs during myocardial infarction (MI), few have progressed into the clinical arena. The epidemiologic and economic impact of MI necessitates the development of innovative therapies to rapidly and effectively reduce the initial injury and subsequent cardiac dysfunction. The Eph receptors and their cognate ligands, the ephrins, are the largest family of receptor tyrosine kinases, and their signaling has been shown to play a diverse role in various cellular processes. The recent advances in the study of ephrin– Eph signaling have shown promising progress in many fields of medicine. They have been implicated in the pathophysiology of various cancers and in the regulation of inflammation and apoptosis. Recent studies have shown that manipulation of ephrin–Eph cell signaling can favorably influence cardiomyocyte viability and ultimately preserve cardiac function post-MI. In this article, we explore the hypothesis that manipulation of ephrin–Eph signaling may potentially be a novel therapeutic target in the treatment of MI through alteration of the cellular processes that govern injury and wound healing.
Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating
Creators: name: Cefalu, William T.
name: Boettiger, Charlotte A.
name: Brownley, Kimberly A.
name: Young, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Dietary chromium supplementation for the treatment of diabetes remains controversial. The prevailing view that chromium supplementation for glucose regulation is unjustified has been based upon prior studies showing mixed, modest-sized effects in patients with type 2 diabetes (T2DM). Based on chromium's potential to improve insulin, dopamine, and serotonin function, we hypothesize that chromium has a greater glucoregulatory effect in individuals who have concurrent disturbances in dopamine and serotonin function – that is, complex patients with comorbid diabetes, depression, and binge eating. We propose, as suggested by the collective data to date, the need to go beyond the “one size fits all” approach to chromium supplementation and put forth a series of experiments designed to link physiological and neurobehavioral processes in the chromium response phenotype.
From the lightest nuclei to the equation of state of asymmetric nuclear matter with realistic nuclear interactions
Creators: name: Gandolfi, S.
name: Lovato, A.
name: Carlson, J.
name: Schmidt, Kevin E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present microscopic calculations of light and medium mass nuclei and the equation of state of symmetric and asymmetric nuclear matter using different nucleon-nucleon forces, including a new Argonne version that has the same spin/isospin structure as local chiral forces at next-to-next-to-leading order (N2LO). The calculations are performed using Auxiliary Field Diffusion Monte Carlo (AFDMC) combined with an improved variational wave function. We show that the AFDMC method can now be used to successfully calculate the energies of very light to medium mass nuclei as well as the energy of isospin-asymmetric nuclear matter, demonstrating microscopically the quadratic dependence of the energy on the symmetry energy.
description: 6 pages, 2 figures
Rassegna storica salernitana. A.4, n.1/2(1943)
Creators: name: (:Unkn) Unknown
Publisher: name: Salerno : Linotypografia Matteo Spadafora
Year: 1943

description: A.4, n.1/2(1943): D. Mustilli, Il tempio di Hera Argiva alle foci del Sele, P. 5; C. Carucci, Una svolta nelle elezioni episcopali vista nella Diocesi di Salerno, P. 16; R. Guariglia, Un ambasciatore salernitano del sec. XV: l'Abate Ruggi, P. 27; A. Fava, L'ultimo dei baroni: Ferrante Sanseverino , P. 57; C. Carucci, Nota all'articolo di A. Fava, "L'ultimo dei baroni: Ferrante Sanseverino", P. 82 ; G.M. Monti, Il commercio marittimo medioevale e borbonico di Salerno e dintorni, P. 85; M. Fiore, Il teatro a Salerno nei secoli XVIII e XIX. Note di cronaca (parte I), P. 90; A. Genoino, Note su la Scuola di Posillipo dal carteggio inedito di un artista, P. 106; P. Zancani Montuoro, recensione di “Krauss F., Paestum…”, P. 116; G. Rosi, recensione di “Schiavo A. Monumenti della costa d'Amalfi”, P. 120; G. Rosi, recensione di “Pirri P. Il Duomo di Amalfi e il Chiostro del Paradiso”, P. 123; A. Sorrentino, recensione di “Masuccio Salernitano. Il Novellino”, P. 124; C. Barbagallo, recensione di “Carucci Carlo. Un Feudo ecclesiastico nell'Italia Meridionale: Olevano sul Tusciano”, P. 128; L. Cassese, recensione di “Genoino Andrea. Vicende del libro nel Reame di Napoli, 1815-1860”, P. 129; C. Carucci, Pel IV Centenario dell'apertura del Concilio di Trento, P. 131; C. Carucci, A proposito del monumento a Giovanni da Procida in Salerno, P.132.
description: La Società Salernitana di Storia Patria aderisce al progetto EleA e autorizza la pubblicazione dei fascicoli.
Analyzing attributes of vessel populations
Creators: name: JUNG, I
name: LIN, W
name: BULLITT, E
name: AYLWARD, S
name: MULLER, K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Almost all diseases affect blood vessel attributes (vessel number, radius, tortuosity, and branching pattern). Quantitative measurement of vessel attributes over relevant vessel populations could thus provide an important means of diagnosing and staging disease. Unfortunately, little is known about the statistical properties of vessel attributes. In particular, it is unclear whether vessel attributes fit a Gaussian distribution, how dependent these values are upon anatomical location, and how best to represent the attribute values of the multiple vessels comprising a population of interest in a single patient.
Investigating the cell biology of plant infection by the rice blast fungus Magnaporthe oryzae
Creators: name: Quime, Berlaine G.
name: Yan, Xia
name: Were, Vincent M.
name: Ryder, Lauren S.
name: Talbot, Nicholas J.
Publisher: name: Zenodo
Year: 2023

description: Rice blast disease, caused by the filamentous, ascomycete fungus, Magnaporthe oryzae, is one of the most important limiting factors in rice production. Infection starts when a three-celled conidium lands on the leaf surface, carried by wind or splash dispersal. To enter the rice leaf, the fungus forms a dome-shaped infection structure called an appressorium. The melanized appressorium develops a penetration peg, which differentiates into a narrow primary invasive hypha (IH) and subsequently into bulbous invasive hyphae that colonize the first host cell. Previous live-cell imaging studies have demonstrated that IH are surrounded by the extra-invasive hyphal membrane (EIHM), an invagination of the host plasma membrane, which bounds IH as they proliferate in epidermal rice cells. We have generated a series of rice (cv. Kitaake) transgenic lines expressing green fluorescent protein (GFP)-labelled subcellular components, including the plasma membrane, endoplasmic reticulum (ER), Golgi, nuclei, F-actin, microtubules, early and late endosomes. Using these transgenic lines, we aim to characterize the temporal development of blast disease and create a spatial atlas of the major cellular changes associated with blast infection, in both compatible and incompatible interactions. We have shown that blast infection is associated with disintegration of the F-actin cytoskeleton. We have also classified major changes in membrane organization and integrity during invasive growth. We will report the major plant cellular changes that accompany host tissue colonization by M. oryzae.
Type I interferons drive MAIT cell functions against bacterial pneumonia
Creators: name: López-Rodríguez, Juan Carlos
name: Hancock, Steven J
name: Li, Kelin
name: Crotta, Stefania
name: Barrington, Christopher
name: Suárez-Bonnet, Alejandro
name: Priestnall, Simon L
name: Aubé, Jeffrey
name: Wack, Andreas
name: Klenerman, Paul
name: Bengoechea, Jose A
name: Barral, Patricia
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: subject: Model organisms
subject: Tumour Biology
subject: Genetics & Genomics
subject: Genome Integrity & Repair
subject: Human Biology & Physiology
subject: Chemical Biology & High Throughput
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational & Systems Biology

description: Mucosal-associated invariant T (MAIT) cells are abundant in the lung and contribute to host defense against infections. During bacterial infections, MAIT cell activation has been proposed to require T cell receptor (TCR)–mediated recognition of antigens derived from the riboflavin synthesis pathway presented by the antigen-presenting molecule MR1. MAIT cells can also be activated by cytokines in an MR1-independent manner, yet the contribution of MR1- dependent vs. -independent signals to MAIT cell functions in vivo remains unclear. Here, we use Klebsiella pneumoniae as a model of bacterial pneumonia and demonstrate that MAIT cell activation is independent of MR1 and primarily driven by type I interferons (IFNs). During Klebsiella infection, type I IFNs stimulate activation of murine and human MAIT cells, induce a Th1/cytotoxic transcriptional program, and modulate MAIT cell location within the lungs. Consequently, adoptive transfer or boosting of pulmonary MAIT cells protect mice from Klebsiella infection, with protection being dependent on direct type I IFN signaling on MAIT cells. These findings reveal type I IFNs as new molecular targets to manipulate MAIT cell functions during bacterial infections.
Multi-modal image set registration and atlas formation
Creators: name: Gerig, Guido
name: Davis, Brad
name: Prastawa, Marcel
name: Joshi, Sarang
name: Bullitt, Elizabeth
name: Lorenzen, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: In this paper, we present a Bayesian framework for both generating inter-subject large deformation transformations between two multi-modal image sets of the brain and for the forming of multi-class brain atlases. In this framework, the estimated transformations are generated using the maximal information about the underlying neuroanatomy present in each of the different modalities. This modality independent registration framework is achieved by jointly estimating the posterior probabilities associated with the multi-modal image sets and the high-dimensional registration transformations mapping the two subjects. To maximally use the information present in all the modalities for registration, Kullback-Leibler divergence between the estimated posteriors is minimized. Registration results for image sets composed of multi-modal MR images of healthy adult human brains are presented. Atlas formation results are presented for a population of five infant human brains.
Additional file 1 of Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease: a study protocol of an evidence map
Creators: name: Colombijn, Julia M. T.
name: Idema, Demy L.
name: van der Braak, Kim
name: Spijker, Rene
name: Meijvis, Sabine C. A.
name: Bots, Michiel L.
name: Hooft, Lotty
name: Verhaar, Marianne C.
name: Vernooij, Robin W. M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Appendix 1. search strategy in ClinicalTrials.gov. Appendix 2. search strategy for validation study.
Structural origin of the anomalous temperature dependence of the local magnetic moments in the CaFe$_{2}$As$_{2}$ family of materials
Creators: name: Ortenzi, L.
name: Gretarsson, H.
name: Kasahara, S.
name: Matsuda, Y.
name: Shibauchi, T.
name: Finkelstein, K. D.
name: Wu, W.
name: Julian, S. R.
name: Kim, Young-June
name: Mazin, I. I.
name: Boeri, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report a combination of Fe K$β$ x-ray emission spectroscopy and $ab$-intio calculations to investigate the correlation between structural and magnetic degrees of freedom in CaFe$_{2}$(As$_{1-x}$P$_{x} $)$_{2}$. The puzzling temperature behavior of the local moment found in rare earth-doped CaFe$_{2}$As$_{2}$ [\textit{H. Gretarsson, et al., Phys. Rev. Lett. {\bf 110}, 047003 (2013)}] is also observed in CaFe$_{2}$(As$_{1-x}$P$_{x}$)$_{2}$. We explain this phenomenon based on first-principles calculations with scaled magnetic interaction. One scaling parameter is sufficient to describe quantitatively the magnetic moments in both CaFe$_{2}$(As$_{1-x}$P$_{x} $)$_{2}$ ($x=0.055$) and Ca$_{0.78}% $La$_{0.22}$Fe$_{2}$As$_{2}$ at all temperatures. The anomalous growth of the local moments with increasing temperature can be understood from the observed large thermal expansion of the $c$-axis lattice parameter combined with strong magnetoelastic coupling. These effects originate from the strong tendency to form As-As dimers across the Ca layer in the CaFe$_{2}$As$_{2}$ family of materials. Our results emphasize the dual local-itinerant character of magnetism in Fe pnictides.