cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Repurposing of Chronically Used Drugs in Cancer Therapy: A Chance to Grasp
Creators: name: Hijazi, Mohamad Ali
name: Gessner, André
name: El-Najjar, Nahed
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: repurposing drugs; oncology; off-targets; anti-hypertensives; anti-diabetic agents
subject: 610 Medizin

description: Despite the advancement in drug discovery for cancer therapy, drug repurposing remains an exceptional opportunistic strategy. This approach offers many advantages (faster, safer, and cheaper drugs) typically needed to overcome increased challenges, i.e., side effects, resistance, and costs associated with cancer therapy. However, not all drug classes suit a patient’s condition or long-time use. For that, repurposing chronically used medications is more appealing. This review highlights the importance of repurposing anti-diabetic and anti-hypertensive drugs in the global fight against human malignancies. Extensive searches of all available evidence (up to 30 March 2023) on the anti-cancer activities of anti-diabetic and anti-hypertensive agents are obtained from multiple resources (PubMed, Google Scholar, ClinicalTrials.gov, Drug Bank database, ReDo database, and the National Institutes of Health). Interestingly, more than 92 clinical trials are evaluating the anti-cancer activity of 14 anti-diabetic and anti-hypertensive drugs against more than 15 cancer types. Moreover, some of these agents have reached Phase IV evaluations, suggesting promising official release as anti-cancer medications. This comprehensive review provides current updates on different anti-diabetic and anti-hypertensive classes possessing anti-cancer activities with the available evidence about their mechanism(s) and stage of development and evaluation. Hence, it serves researchers and clinicians interested in anti-cancer drug discovery and cancer management.
Paulus als Theologe und sein Einfluß in der frühen Kirche, 2. Teil
Creators: name: Giesen, Heinz
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
title: Rapport de voyage, De Grasse (1924) : Ligne de New-York, 1948, voyage n°6
Creators: name: Bellet, Robert
name: Champy, Jean
name: Le Mancheo, Jean
name: Verdot, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Compagnie Générale Transatlantique
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport général / du capitaine - Rapport du commissaire - Rapport du second - Rapport de l'officier de sécurité - Rapport de l'officier de navigation - Rapport du médecin - Rapport contentieux
description: Source: French Lines & Compagnies, 1997 004 4979-20
description: Coverage: 1948-06-09/1948-06-30
Blarinomys breviceps
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Blarinomys
Blarinomys breviceps

description: Blarinomys breviceps (Winge 1887)
[Oxymycterus] breviceps Winge 1887, E Museo Lundii, Vol. 1, 3: 34.
Type Locality: Brazil, Minas Gerais, Rio das Velhas, Pleistocene cave deposits near Lagoa Santa.
Vernacular Names: Blarinine Akodont.
Distribution: Atlantic Forest region of SE Brazil (Bahia to São Paulo; Silva et al., 2003) and NE Argentina (Misiones Prov.; Massoia, 1993).
Conservation: IUCN – Lower Risk (nt).
Discussion: Based on compilation of old and new records, Silva et al. (2003) suggested that B. breviceps is extinct at the type locality, now set within Cerrado vegetation, and confined to the more mesic Atlantic Forest zone. See Matson and Abravaya (1977, Mammalian Species, 74).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1104, DOI: 10.5281/zenodo.7316535
Ctenoplusia polycampta Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia polycampta

description: * Ctenoplusia polycampta Dufay, 1972
(Fig. 23, 54, 55, 56, 57)
Material examined. Gambella region, Gambella, 400 m, VIII.1987. Leg. Kravchenko V.
Literature. Dufay 1972.
General distribution pattern. in tropical Africa: Angola, Cameroon, Central African Republic, Democratic Republic of Congo, Gabon, Ivory Coast and Sierra Leone.
Distribution in Ethiopia. Western Ethiopia (Gambella region). Common.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 241, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Brucepattersonius Hershkovitz 1998
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius

description: Brucepattersonius Hershkovitz 1998
Brucepattersonius Hershkovitz 1998, Bonn. Zool. Beitr., Vol. 47: 227.
Type Species: Brucepattersonius soricinus Hershkovitz 1998
Species and subspecies: 8 species:
Species Brucepattersonius albinasus Hershkovitz 1998
Species Brucepattersonius griserufescens Hershkovitz 1998
Species Brucepattersonius guarani Mares and Braun 2000
Species Brucepattersonius igniventris Hershkovitz 1998
Species Brucepattersonius iheringi (Thomas 1896)
Species Brucepattersonius misionensis Mares and Braun 2000
Species Brucepattersonius paradisus Mares and Braun 2000
Species Brucepattersonius soricinus Hershkovitz 1998
Discussion: Akodontini. Morphological traits resemble those of Oxymycterus, considered its probable nearest generic relative by Hershkovitz (1998). Parsimony and likelihood trees derived from cytochrome b data instead most closely relate the genus to Blarinomys, within a clade that includes Lenoxus, Kunsia, and Scapteromys (D’Elía et al., 2003; Smith and Patton, 1999). With recognition of this distinctive genus, attention should be directed to documenting the status and distributions of the newly described forms, most known only from their type locality and based on differentiating traits that intimate age and-or individual variation.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1104, DOI: 10.5281/zenodo.7316535
Ctenoplusia perispomena Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia perispomena

description: Ctenoplusia perispomena (Dufay, 1972)
(Figs. 24; 58, 59)
Material examined. Oromia Region, Wonchi Crater, 3300 m, V.2009. Leg. Kravchenko V.; Oromia Region, Jimma. 1900 m, V.2009. Leg. Kravchenko V.
Literature. Dufay 1972; Dufay & Laporte 1977.
General distribution pattern. In tropics of East Africa: Ethiopia, Kenya, Tanzania and Uganda.
Distribution in Ethiopia. Everywhere except deserts. Common.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 242, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Witchellia striata Sandoval 2022, n. sp.
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Witchellia
Witchellia striata

description: Witchellia striata n. sp. [M]
(Figs 11D; 13 G-H)
urn:lsid:zoobank.org:act: 565D9D7B-5E38-4DA9-82A3-74C76491E98B
Witchellia rubra – Sandoval 1990: 146, pl. 1, fig.7, non Buckman, 1926.
DIAGNOSIS. — Macroconch, planulate, relatively involute with shallow umbilicus, compressed rectangular section with a very shallow depression in the lower part of the flanks, tabulate venter with a relatively high hollow keel. Weak falcate ribbing that progressively fades, being replaced by bundles of striae. The septal suture is simple.
TYPE MATERIAL. — Holotype: specimen JAC11.4.27, held in the Department of Stratigraphy and Palaeontology, Faculty of Sciences, University of Granada (Spain).
TYPE LOCALITY AND OCCURRENCE. — Sierra Alta Coloma (JAC11 section; Jaén Province), central sector of the Median Subbetic, Betic Cordillera, S Spain, Lower Bajocian (Laeviuscula Zone, Trigonalis Subzone).
DERIVATION OF NAME. — Ornamentation composed mainly of striae.
MATERIAL EXAMINED. — Two specimens: JAC4.36.1, JAC11.4.27 (HT).
MEASUREMENTS. — See Table 20.
DESCRIPTION
Planulate semi-involute, medium-sized shells, with appreciable uncoiling throughout ontogeny and with medium-wide, shallow umbilicus. An almost rectangular compressed whorl section (Fig. 11D), which has a vertical umbilical wall, an abrupt umbilical edge at right angles, and almost flat flanks with a very shallow depression (barely noticeable) in its lower part. The venter is clearly tabulate with a high hollow keel. The aperture is not well preserved, although the holotype is almost complete and appears to be adult. The inner and middle whorls support fine falcate ribs, which are single or divided into the inner third of the flanks. The weak and poorly marked secondaries strongly project forward along the ventrolateral edge. From the last part of the PH, ribbing progressively weakens, being replaced by bundles of striae or by very faint ribs in the BC. The septal suture, typical of Witchellia, has short lobes and low saddles.
REMARKS
These Subbetic forms are quite similar to the HT of W. hyalina but are slightly more involute, have less marked ribs on inner whorls, falcate rather than sinuous ornamentation, and bear striae that form bundles in the BC. Moreover, the new species appears to be chronostratigraphically earlier. W. romanoides is more evolute, has any depression in the lower part of the flank and has more pronounced and less striate ornamentation.
DISTRIBUTION
Laeviuscula Zone, Trigonalis Subzone; Sierra de Alta Coloma (sections JAC4 and JAC11; Jaén Province).
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on pages 835-836, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Predictors of Mortality in Head-Preserving Treatment for Dislocated Proximal Humerus Fractures: A Retrospective Analysis of 522 Cases with a Minimum Follow-Up of 5 Years
Creators: name: Klute, Lisa
name: Henssler, Leopold
name: Pfeifer, Christian
name: Berner, Arne
name: Schneider, Teresa
name: Kobeck, Miriam
name: Alt, Volker
name: Kerschbaum, Maximilian
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: mortality; humerus fractures; proximal humerus; shoulder
subject: 610 Medizin

description: Purpose: Proximal humerus fractures (PHFs) are among the most common fractures in elderly patients, but there is still inadequate knowledge about mortality risk factors after such injuries. In order to provide the best possible therapy, individual risk factors have to be considered and evaluated thoroughly. There is still controversy regarding treatment decisions for proximal humerus fractures, particularly for the elderly. Methods: In this study, patient data from 522 patients with proximal humerus fractures were obtained from 2004 to 2014 at a Level 1 trauma centre. After a minimum follow-up of 5 years, the mortality rate was assessed, and independent risk factors were evaluated. Results: A total of 383 patients (out of 522) were included in this study. For our patient collective, the mean follow-up was at 10.5 ± 3.2 years. The overall mortality rate was 43.8% in our respondent group and was not significantly impacted by concomitant injuries. The binary logistic regression model showed an increased risk for mortality by 10% per life year, a 3.8 times higher mortality risk for men as well as for conservative treatment. The most powerful predictor was a Charlson Comorbidity Index of more than 2, with a 16 times higher mortality risk. Conclusions: Outstanding independent predictors of death in our patient collective were serious comorbidities, male patients, and conservative treatment. This patient-related information should influence the process of decision making for the individual treatment of patients with PHFs.
title: Rapport de voyage, Chantilly (1922) : Ligne de l'Indochine, 1947, voyage n°30
Creators: name: Angaud, Georges
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Compagnie des Messageries Maritimes
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport du commandant - Rapport de mer
description: Source: French Lines & Compagnies, 1997 002 3993-25
description: Coverage: 1947-07-01/1947-09-15
In situ veritas: combining omics and multiplex imaging can facilitate the detection and characterization of cell-cell interactions in tissues
Creators: name: Ritter, Uwe
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: proteomics, RNA-seq, spatial transcriptomics, multiplex imaging, physically interacting cells, dendritic cells, T cells
subject: 610 Medizin

description: In 1898, microscopic examinations were used to study changes in lymphoid tissues and cell distribution in pathological settings (1). More than 100 years after these first discoveries, the complexity of lymphoid organ composition and the existence of distinct immune-cell subpopulations with a diverse set of functions has been described.

For the adaptive immune system to function efficiently, complex series of spatial and temporal interactions between specialized immune cells must take place. This has been a field of vigorous interest, exemplified by the fact that nearly 100.000 papers have been published dealing with the keywords “interaction” and “immune cells” (PubMed search March 2023). Understanding cell-cell communication—resulting in immunological pathways—is being supported by a range of sophisticated analysis pipelines, ranging from in vitro and ex vivo single-cell sequencing analysis to genic analysis of immunological alterations. In this context, it is commonly accepted that cells can communicate through juxtacrine and paracrine processes (2). Signal transmission and reception between neighboring cells is fundamentally involved in the regulation of immunological processes, ranging from tissue homeostasis to defense mechanisms against tumour cells or pathogens. However, the final decryption of immunological programs responsible for coordinated and dynamic immunological adaption is multi-factorial and remains challenging.
Proximal Humerus Fractures in the Elderly U.S. Population: A Cross-Sectional Study of Treatment Trends and Comparison of Complication Rates after Joint Replacement, Open Reduction and Internal Fixation, and Non-Surgical Management
Creators: name: Walter, Nike
name: Szymski, Dominik
name: Riedl, Moritz
name: Kurtz, Steven M.
name: Alt, Volker
name: Lowenberg, David W.
name: Lau, Edmund C.
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: complication rates; epidemiology; proximal humerus fractures; risk factors; treatment
subject: 610 Medizin

description: Proximal humerus fracture (PHF) treatment remains challenging. Multiple therapy options exist, and the optimal choice of management has been increasingly discussed in the literature. The aim of this study was to (1) analyze trends in the propensity of proximal humerus fracture treatments and (2) compare complication rates after joint replacement, surgical repair, and non-surgical treatment in terms of mechanical complications, union failure, and infection rates. In this cross-sectional study, patients aged 65 years or older with proximal humerus fractures occurring between 1 January 2009 and 31 December 2019 were identified from Medicare physician service claims records. The Kaplan–Meier method with the Fine and Gray adjustment was used to calculate the cumulative incidence rates for malunion/nonunion, infection, and mechanical complications for the following treatment categories: shoulder arthroplasty, open reduction and internal fixation (ORIF), and non-surgical treatment, respectively. Semiparametric Cox regression was performed incorporating 23 demographic, clinical, and socioeconomic covariates to determine risk factors. Between 2009 through 2019, conservative procedures decreased by 0.9%. ORIF procedures decreased from 9.51% (95% CI: 8.7–10.4) to 6.95% (95% CI: 6.2–7.7), whereas shoulder arthroplasties rose from 1.99% (95% CI: 1.6–2.4), to 5.45% (95% CI: 4.8–6.2). PHFs managed through ORIF were associated with higher union failure rates compared to conservatively treated fractures (HR = 1.31, 95% CI: 1.15–1.5, p < 0.001). The risk of developing an infection was increased after joint replacement compared to ORIF (2.66% vs. 1.09%, HR = 2.09, 95% CI: 1.46–2.98, p < 0.001). Mechanical complications were more common after joint replacement (6.37% vs. 4.85%, HR = 1.66, 95% CI: 1.32–2.09, p < 0.001). Complication rates differed significantly across treatment modalities. This should be considered when choosing a management procedure. Vulnerable elderly patient cohorts could be identified, and the optimization of modifiable risk factors might lead to a decrease of complication rates in both surgically and non-surgically treated patients.
The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery
Creators: name: Rupp, Markus
name: Walter, Nike
name: Szymski, Dominik
name: Taeger, Christian
name: Langer, Martin Franz
name: Alt, Volker
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Soft tissue defects resulting from trauma and musculoskeletal infections can complicate surgical
treatment. Appropriate temporary coverage of these defects is essential to achieve the best outcomes for necessary
plastic soft tissue defect reconstruction. The antibiotic bead pouch technique is a reasonable surgical
approach for managing temporary soft tissue defects following adequate surgical debridement. This technique
involves the use of small diameter antibiotic-loaded bone cement beads to fill the dead space created by debridement.
By applying antibiotics to the bone cement and covering the beads with an artificial skin graft, high local
dosages of antibiotics can be achieved, resulting in the creation of a sterile wound that offers the best starting
position for soft tissue and bone defect reconstruction.
This narrative review describes the rationale for using this technique, including its advantages and disadvantages,
as well as pearls and pitfalls associated with its use in daily practice. In addition, the article provides a
comprehensive overview of the literature that has been published since the technique was introduced in surgical
practice.
Brucepattersonius albinasus Hershkovitz 1998
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius albinasus

description: Brucepattersonius albinasus Hershkovitz 1998
Brucepattersonius albinasus Hershkovitz 1998, Bonn. Zool. Beitr., Vol. 47: 235.
Type Locality: Brazil, Minas Gerais State, Parque Nacional de Caparaó, Pico de Bandeira, 2700 m.
Vernacular Names: White-nosed Akodont.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1104, DOI: 10.5281/zenodo.7316535
title: Activité du port de Saint-Malo – 1746 – Morlaix
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits exotiques et ultramarins
subject: dopants

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1746 avec le port "Morlaix"
description: Marchandises au départ de Saint-Malo : tabac
description: Catégories de marchandises au départ de Saint-Malo : produits exotiques et ultramarins ; dopants
description: Coverage: Petit cabotage
description: Bibliographic citation: FONTENEAU, Yves-Luc. L'Activité du port de Saint-Malo : deux aspects de la guerre de course entre 1744 et 1748. Théorie et réalités, déserteurs et mutins. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1040)
description: Bibliographic citation: LEFUR, Anne-Marie. Activités du port de Saint-Malo en 1745-1746. DES : Histoire : Rennes : 1965 (Bibliothèque François-Lebrun, MH 1039)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Ctenoplusia furcifera subsp. ogowana
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia furcifera
Ctenoplusia furcifera ogowana (holland, 1894)

description: Ctenoplusia furcifera ogowana (Holland, 1894)
(Fig. 25)
Material examined. Oromia Region, Wonchi Crater. 3300 m., V.2009. Leg. Kravchenko V.; Oromia Region, Jimma. 1900 m. V.2009. Leg. Kravchenko V.
Literature. Behounek & Ronkay 1989; Behounek et al. 2010; Berio et al. 1984; Dufay 1970; Hacker et al. 2001; Hacker et al. 1999; Kravchenko et al. 2007; Ronkay 1987; Rougeot 1983.
General distribution pattern. In tropical and subtropical Africa: Burkina Faso, Cameroon, Comoros, Equatorial Guinea, including Island Bioko, Ethiopia, Gabon, Ivory Coast, Madagascar, Nigeria, South Africa, Tanzania, Zambia and Zimbabwe. In the Palearctic region it was found in Saudi Arabia.
Distribution in Ethiopia. Everywhere except deserts, in Bale Mts common on elevations up to 3.300 m. Common.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 242, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
All-oral low-dose chemotherapy TEPIP is effective and well-tolerated in patients with peripheral T-cell lymphoma
Creators: name: Fante, Matthias A.
name: Harrer, Dennis C.
name: Zartner, Barbara
name: Lüke, Florian
name: Mayer, Stephanie
name: Menhart, Karin
name: Reichle, Albrecht
name: Herr, Wolfgang
name: Vogelhuber, Martin
name: Heudobler, Daniel
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: TEPIP, relapsed/refractory PTCL, PTCL, metronomic chemotherapy, all-oral treatment, relapsed lymphoma, palliative treatment
subject: 610 Medizin

description: Purpose: Peripheral T-cell lymphoma (PTCL) is a rare and heterogenous hematologic malignancy with poor prognosis especially in elderly and frail patients who are not eligible for intensive treatment. The resulting palliative setting necessitates tolerable but effective schedules for outpatient treatment. TEPIP is a locally developed, all-oral low-dose regimen comprising trofosfamide, etoposide, procarbazine, idarubicin, and prednisolone.

Methods: In this observational retrospective, single-center study, the safety and efficacy of TEPIP was evaluated in 12 patients (pts.) with PTCL treated at the University Medical Center Regensburg between 2010 and 2022. The endpoints were overall response rate (ORR) and overall survival (OS), and adverse events were individually reported according to the Common Terminology Criteria for Adverse Events (CTCAE) criteria.

Results: The enrolled cohort was characterized by advanced age (median 70 years), extensive disease (100% Ann Arbor ≥stage 3), and poor prognosis (75% high/high-intermediate international prognostic index). The most common subtype was angioimmunoblastic T-cell lymphoma (8/12), and 11/12 patients had relapsed or refractory disease at TEPIP onset with a median of 1.5 prior treatment regimens. After a median of 2.5 TEPIP cycles (total of 83 cycles), the ORR was 42% (complete remission 25%), and the OS reached a median of 185 days. Any grade of adverse event (AE) occurred in 8/12 patients, with four patients showing AE ≥CTCAE grade 3 (33%), and the AEs were mainly non-hematological.

Conclusion: TEPIP demonstrated competitive efficacy with a tolerable safety profile in a highly palliative cohort of patients with difficult-to-treat PTCL. The all-oral application, which makes outpatient treatment possible, is particularly noteworthy.
title: Activité du port de Saint-Malo – 1734 – Newcastle
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits combustibles

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1734 avec le port "Newcastle"
description: Marchandises arrivées à Saint-Malo : charbon de terre
description: Catégories de marchandises arrivées à Saint-Malo : produits combustibles
description: Coverage: Grand commerce
description: Bibliographic citation: LE THUAUT, Gabrielle. Étude du commerce malouin en 1734. DES : Histoire : Rennes : 1965 (Bibliothèque François-Lebrun, MH 1031)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Witchellia minima
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Witchellia
Witchellia minima

description: Witchellia minima (Hiltermann, 1939) [m] (Fig. 14J)
Sonninia deltafalcata minima Hiltermann, 1939: 174, pl. 12, figs 4, 6.
Sonninia (Poecilomorphus) boweri minima – Huf 1968: 50, pl. 4, figs 4(LT refigured)-6.
Pelekodites minimus – Morton 1975: 66, pl. 10, figs 23, 24, 31-34.
Maceratites minimus – Fernández-López 1985: 104, pl. 11, fig. 16.
? Pelekodites aff. minimus [m] – Dietze et al. 2007: 6, fig. 4c.
MATERIAL EXAMINED. — JAC22.26.2 and JAC22.43.26.
MEASUREMENTS. — See Table 23.
DESCRIPTION
Small evolute microconch with slightly compressed ovate whorl section, rounded umbilical edge and barely convex flanks, as well as a rounded venter with a faint keel. It is scarcely ornamented with smooth inner whorls; intermediate whorls have barely visible irregular sigmoid ribs, some bifurcating near the umbilical edge. The outer whorls are smooth or almost so. The peristome has spatulate lappets and a small ventral rostrum. The septal suture is not preserved in the Subbetic specimen.
REMARKS W. macer is the most similar species to W. minima, but it is somewhat larger and has a more marked ribbing. In the Subbetic, both taxa appear at equivalent stratigraphic levels. W.minima may represent an extreme morphotype of W. macer.
DISTRIBUTION
In Scotland, W. minima occurs in the Laeviuscula and Propinquans? zones (Morton 1975). Dietze et al. (2007) cited “ P.” aff. minimus in the Ovale Zone of Dundry Hill, Somerset (SW England). In the Iberian range (Spain), the species is present in the Ovale and Laeviuscula zones (Fernández-López 1985) and in the Atlas (Morocco) it occurs in the Laeviuscula Zone (Sadki 1996). The Subbetic specimens are from the Laeviuscula Zone of JAC22 section, Sierra de Alta Coloma area (Jaén Province).
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on page 838, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Brucepattersonius griserufescens Hershkovitz 1998
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius griserufescens

description: Brucepattersonius griserufescens Hershkovitz 1998
Brucepattersonius griserufescens Hershkovitz 1998, Bonn. Zool. Beitr., Vol. 47: 233.
Type Locality: Brazil, Minas Gerais State, Parque Nacional de Caparaó, Terreirao, 2400 m.
Vernacular Names: Gray-bellied Akodont.
Distribution: Humid montane forest and scrub, 1300-2700 m, E Minas Gerais and Espírito Santo to Rio de Janeiro, SE Brazil.
Discussion: Distribution amplified and karyotype reported by Bonvicino et al. (1998 b), who noted that it (2n = 52, FN = 52-53) differs from all Oxymycterus species so far examined (2n = 54, FN = 64; see Bonvicino et al., 1998 b).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1104, DOI: 10.5281/zenodo.7316535
Intestinal IgA positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both, graft-versus-host disease and relapse related mortality
Creators: name: Scheidler, Lucia
name: Hippe, Katrin
name: Ghimire, Sakhila
name: Weber, Daniela
name: Weber, Markus
name: Meedt, Elisabeth
name: Hoffmann, Petra
name: Lehn, Petra
name: Burkhardt, Ralph
name: Mamilos, Andreas
name: Edinger, Matthias
name: Wolff, Daniel
name: Poeck, Hendrik
name: Evert, Matthias
name: Gessner, André
name: Herr, Wolfgang
name: Holler, Ernst
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Intestinal IgA is strongly involved in microbiota homeostasis. Since microbiota disruption is a major risk factor of acute GvHD, we addressed the kinetics of intestinal IgA-positive (IgA+) plasma cells by immunohistology in a series of 430 intestinal biopsies obtained at a median of 1,5 months after allogeneic stem cell transplantation from 115 patients (pts) at our center. IgA+ plasma cells were located in the subepithelial lamina propria and suppressed in the presence of histological aGvHD (GvHD lerner stage 0: 131+/- 8 IgA+ plasma cells/mm2; stage 1-2: 108 +/-8 IgA+ plasma cells/ mm2; stage 3-4: 89+/-16 IgA+ plasma cells/ mm2, p 0.004). Overall, pts with IgA+ plasma cells below median had an increased treatment related mortality (p = 0.04). Time courses suggested a gradual recovery of IgA+ plasma cells after day 100 in the absence but not in the presence of GvHD. Vice versa IgA+ plasma cells above median early after SCT were predictive of relapse and relapse related mortality (RRM): Pts with low IgA+ cells had a 15% RRM at 2 and at 5 yrs, while pts with high IgA+ cells had a 31% RRM at 2 years and more than 46% at 5 years; multivariate analysis indicated high IgA+ plasma cells in biopsies (HR 2.7 (95% CI 1.04-7.00) as independent predictors of RRM, whereas Lerner stage and disease stage themselves did not affect RRM. In contrast, IgA serum levels at the time of biopsy were not predictive for RRM. In summary, our data indicate that IgA+ cells are highly sensitive indicators of alloreaction early after allo-SCT showing association with TRM but also allowing prediction of relapse independently from the presence of overt GvHD.
Ctenoplusia dargei Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia dargei

description: * Ctenoplusia dargei Dufay, 1972
(Figs. 26, 60, 61)
Material examined. Gambella region, Gambella. 400 m. VIII.1988. Leg. Kravchenko V.
Literature. Dufay 1972; Dufay & Laporte 1977.
General distribution pattern. In tropics of West Africa: Cameroon, Equatorial Guinea, including Island Bioko, and Ghana.
Distribution in Ethiopia. Western Ethiopia (Gambella region). Rare.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 242, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities
Creators: name: Harrer, Dennis Christoph
name: Bezler, Valerie
name: Hartley, Jordan
name: Herr, Wolfgang
name: Abken, Hinrich
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: CAR, IRF4, exhaustion, sensitivity, tumor
subject: 610 Medizin

description: Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors. Crucial barriers to long-term CAR T cell success encompass loss of functional capacities known as “exhaustion”, among others. To extend CAR T cell functionality, we reduced interferon regulatory factor 4 (IRF4) levels in CAR T cells using a one-vector system encoding a specific short-hairpin (sh) RNA along with constitutive CAR expression. At baseline, CAR T cells with downregulated IRF4 showed equal cytotoxicity and cytokine release compared to conventional CAR T cells. However, under conditions of repetitive antigen encounter, IRF4low CAR T cells displayed enhanced functionality with superior cancer cell control in the long-term compared with conventional CAR T cells. Mechanistically, the downregulation of IRF4 in CAR T cells resulted in prolonged functional capacities and upregulation of CD27. Moreover, IRF4low CAR T cells were more sensitive to cancer cells with low levels of target antigen. Overall, IRF4 downregulation capacitates CAR T cells to recognize and respond to target cells with improved sensitivity and endurance.
Brucepattersonius guarani Mares and Braun 2000
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius guarani

description: Brucepattersonius guarani Mares and Braun 2000
Brucepattersonius guarani Mares and Braun 2000, Occas. Pap. Sam Noble Oklahoma Mus. Nat. Hist., 9: 9.
Type Locality: Argentina, Misiones Prov., Guaraní Dept., 6 km NE (by Hwy 2) junction of Hwy 2 and Arroyo Paraíso, 360 m.
Vernacular Names: Guarani Akodont.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1104, DOI: 10.5281/zenodo.7316535
title: Activité du port de Saint-Malo – 1752 – Île Royale
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: produits manufacturés
subject: épices et condiments
subject: poissons
subject: produits combustibles
subject: matériaux de construction

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1752 avec le port "Ile Royale"
description: Marchandises au départ de Saint-Malo : sel ; ustensiles de pêche
description: Catégories de marchandises au départ de Saint-Malo : produits de la mer ; produits manufacturés ; épices et condiments
description: Marchandises arrivées à Saint-Malo : morues ; huile ; bois
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; poissons ; produits combustibles ; matériaux de construction
description: Coverage: Grand commerce
description: Bibliographic citation: PAITRY, Daniel. Les Activités commerciales et la vie du port de Saint-Malo en 1752. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1043)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Plasma Chemerin Is Induced in Critically Ill Patients with Gram-Positive Infections
Creators: name: Amend, Pablo
name: Mester, Patricia
name: Schmid, Stephan
name: Müller, Martina
name: Buechler, Christa
name: Pavel, Vlad
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: COVID-19; C-reactive protein; sepsis; bacterial infection; sepsis biomarker; Gram-positive bacteria
subject: 610 Medizin

description: Chemerin is a chemoattractant protein abundantly expressed in hepatocytes. Chemerin exerts pro- and anti-inflammatory effects and acts as a pro-resolving protein. Chemerin levels are low in patients with liver cirrhosis and are increased in sepsis. The aim of this study was to identify associations between plasma chemerin levels and underlying diseases as well as causes of severe illness. The cohort included 32 patients with liver cirrhosis who had low systemic chemerin, and who were not considered for further evaluation. Plasma chemerin levels were similar between the 27 patients with systemic inflammatory response syndrome (SIRS), the 34 patients with sepsis and the 63 patients with septic shock. Chemerin in plasma correlated with C-reactive protein and leukocyte count but not with procalcitonin, a clinical marker of bacterial infection. Plasma chemerin did not differ among patients with and without ventilation and patients with and without dialysis. Vasopressor therapy was not associated with altered plasma chemerin levels. Infection with severe acute respiratory syndrome coronavirus 2 had no effect on plasma chemerin levels. Baseline levels of plasma chemerin could not discriminate between survivors and non-survivors. Notably, Gram-positive infection was associated with higher chemerin levels. In summary, the current study suggests that plasma chemerin might serve as an early biomarker for the diagnosis of Gram-positive infections in patients with sepsis.
Ctenoplusia phocea Hampson 1910
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia phocea

description: Ctenoplusia phocea (Hampson, 1910)
(Fig. 27)
Material examined. Gambella region, Gambella, 400 m, VIII.1987. Leg. Kravchenko V.; Bako Gazer woreda, Mago National Park, 600 m, VIII.2011. Leg. Kravchenko V.
Literature. Behounek & Ronkay 1989; Behounek et al. 2010; Dufay 1970; Dufay & Laporte 1977; Kravchenko et al. 2007.
General distribution pattern. throughout tropical and subtropical Africa: Burundi, Cameroon, Equatorial Guinea including Island Bioco, Ethiopia, Gabon, Ghana, Ivory Coast, Kenya, Nigeria, South Africa, São Tomé & Principe, Tanzania, Uganda and Zimbabwe. In the Palearctic region it is known from Yemen.
Distribution in Ethiopia. In western and southern Ethiopia (Gambella, Oromia and Omo regions).
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 242, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Rustic Capital Writing in Herculaneum papyri
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 76
description: "Study of the following Latin papyri classified under the name 'Capitale rustique classique': P.Herc. 1066, 1067, 1070, 1472, 1475, 1484, 1535, 1558, 1644 (the folder contains a brief description of P.Herc 1066). All the mentioned papyri are listed on the cover page of the main folder together with all the papyri studied in 4MAR_9_2_5-12 (classified as 'Capitale livresque'). The numbers of the papyri studied in 4MAR_9_2_5-12 are marking in different ink meaning 'recopié'; some numbers are accompanied by the indication 'micro' (in different ink). In addition to some bibliographical notes, the indication 'Vu 54 - fini - Revue 58' is written at the end of the list. The study related to each papyrus is enclosed in one folder with the number of the papyrus written on the upper right corner; in some cases the sheets related to two papyri are inserted in one single folder, and one of the two numbers is written in a different ink."
description: Source: 4MAR_9_2_5-16
description: Relation: 4MAR_2_5-12,
description: created: n.d., 1957
Sensory-Processing Sensitivity Is Associated with Increased Neural Entropy
Creators: name: Walter, Nike
name: Meinersen-Schmidt, Nicole
name: Kulla, Patricia
name: Loew, Thomas
name: Kruse, Joachim
name: Hinterberger, Thilo
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: sensory-processing sensitivity; EEG; self-organized criticality; nonlinear dynamics; entropy
subject: 610 Medizin

description: Background: This study aimed at answering the following research questions: (1) Does the self-reported level of sensory-processing sensitivity (SPS) correlate with complexity, or criticality features of the electroencephalogram (EEG)? (2) Are there significant EEG differences comparing individuals with high and low levels of SPS? 
Methods: One hundred fifteen participants were measured with 64-channel EEG during a task-free resting state. The data were analyzed using criticality theory tools (detrended fluctuation analysis, neuronal avalanche analysis) and complexity measures (sample entropy, Higuchi’s fractal dimension). Correlations with the ‘Highly Sensitive Person Scale’ (HSPS-G) scores were determined. Then, the cohort’s lowest and the highest 30% were contrasted as opposites. EEG features were compared between the two groups by applying a Wilcoxon signed-rank test. 
Results: During resting with eyes open, HSPS-G scores correlated significantly positively with the sample entropy and Higuchi’s fractal dimension (Spearman’s ρ = 0.22, p < 0.05). The highly sensitive group revealed higher sample entropy values (1.83 ± 0.10 vs. 1.77 ± 0.13, p = 0.031). The increased sample entropy in the highly sensitive group was most pronounced in the central, temporal, and parietal regions. 
Conclusion: For the first time, neurophysiological complexity features associated with SPS during a task-free resting state were demonstrated. Evidence is provided that neural processes differ between low- and highly-sensitive persons, whereby the latter displayed increased neural entropy. The findings support the central theoretical assumption of enhanced information processing and could be important for developing biomarkers for clinical diagnostics.
La serietà norma di sé e del fatuo
Creators: name: Regina, Luciana
Publisher: name: Spazio Filosofico
Year: 2016

description: The intuition from which we start is that the conceptual crisis affecting seriousness is one of the major features that characterize our time. In this context, by “conceptual crisis” one should understand a condition of extreme vagueness affecting a concept whose task should be instead that of accurately educating individuals to the kind of respect due to reality in all its specific manifestations.


One could say of seriousness what Spinoza thought of truth, namely, that seriousness is the standard of both itself and the fatuous. What seriousness discloses in its rare epiphanies is its a posteriori unequivocality. Combining this element with its irrelevance in everyday affairs creates a philosophical problem and several social issues.
description: Spazio Filosofico, 18. Serietà
The patients‘ perspective - a qualitative analysis of experiencing a fracture-related infection
Creators: name: Wimalan, Bravena
name: Rupp, Markus
name: Alt, Volker
name: Walter, Nike
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: qualitative analysis, fracture-related infection, emotional impact, psychological resources, multidisciplinary management
subject: 610 Medizin

description: Introduction: Fracture-related infection is a devastating complication confronting the patient with several challenges. To improve the management and to enhance the patients’ wellbeing the focus of this study was to understand the emotional impact and patients’ experiences during the process to identify challenges, difficulties, and resources. For this, a qualitative content analysis of semi-structured interviews according to Graneheim and Lundman was performed.

Methods: In total n = 20 patients of a German university orthopedic trauma centre specialized in bone and joint infections were recruited using a purposive sampling strategy. The patients were treated at the hospital between 2019 and 2021 and underwent at least one surgery. Individual in-person interviews were performed by one researcher based on a semi-structured guide, which was previously conceptualized. Content analysis according to Graneheim and Lundman was performed on the transcripts by two of the researchers independently.

Results: The following major themes emerged: (i) the emotional and mental aspects highlighting the fact that FRI patients faced severe restrictions in their day-to-day life, which resulted in dependency on others and frustration, as well as future concerns showing that patients could not overcome a state of anxiety and fear even after successful treatment, (ii) socioeconomic consequences confronting patients with consequences on the job and in finances where they often feel helpless, and (iii) resources emphasizing the role of spirituality as a coping strategy and yoga exercises for keeping the positivity.

Conclusion: This study emphasized the challenge of fracture-related infection management and associated consequences from the patients’ perspective. Not being well informed about possible negative outcomes or restrictions makes it harder for patients to accept the situation and patients expressed a need for better information and certainty. Also, patients developed constant anxiety and other psychological disturbances, highlighting the potential benefit of psychological support and patient-peer support to exchange experiences.