cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis
Creators: name: Kang, Sen
name: Liu, Shuxin
name: Dong, Xian
name: Li, Haoyu
name: Qian, Yuanyi
name: Dai, Anna
name: He, Wentao
name: Li, Xiaojun
name: Chen, Qianming
name: Wang, Huiming
name: Ding, Pei-Hui
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Periodontitis, a prevalent and chronic inflammatory disease, is intricately linked with macroautophagy/autophagy, which has a dual role in maintaining periodontal homeostasis. Despite its importance, the precise interplay between autophagy and periodontitis pathogenesis remains to be fully elucidated. In this study, our investigation revealed that the ubiquitination of RAB7A, mediated by reduced levels of the deubiquitinating enzyme USP4 (ubiquitin specific peptidase 4), disrupts normal lysosomal trafficking and autophagosome-lysosome fusion, thereby contributing significantly to periodontitis progression. Specifically, through genomic and histological analysis of clinical gingival samples, we observed a decreased RAB7A expression and impaired autophagic activity in periodontitis. This was further substantiated through experimental periodontitis mice, where RAB7A inactivation was shown to directly affect autophagy efficiency and drive periodontitis progression. Next, we explored the function of active RAB7A to promote lysosomal trafficking dynamics and autophagosome-lysosome fusion, which was inhibited by RAB7A ubiquitination in macrophages stimulated by Porphyromonas gingivalis (P. g.), one of the keystone pathogens of periodontitis. Last, by proteomics analysis, we revealed that the ubiquitination of RAB7A was mediated by USP4 and validated that upregulation of USP4 could attenuate periodontitis in vivo. In conclusion, these findings highlight the interaction between USP4 and RAB7A as a promising target for therapeutic intervention in managing periodontal diseases. Abbreviation: 3-MA: 3-methyladenine; Baf A1:bafilomycin A1; BECN1: beclin 1, autophagy related; CEJ-ABC: cementoenamel junctionto alveolar bone crest; IL1B/IL-1β: interleukin 1 beta; KD:knockdown; LPS: lipopolysaccharide; MOI: multiplicity of infection;OE: overexpression; P.g.: Porphyromonasgingivalis; RILP: Rabinteracting lysosomal protein; ScRNA-seq: single-cell RNA sequencing; SQSTM1/p62: sequestosome 1; S.s.: Streptococcus sanguinis; USP4:ubiquitin specific peptidase 4
Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis
Creators: name: Choi, You-Jin
name: Nam, Yoon Ah
name: Hyun, Ji Ye
name: Yu, Jihyeon
name: Mun, Yewon
name: Yun, Sung Ho
name: Lee, Wonseok
name: Park, Cheon Jun
name: Han, Byung Woo
name: Lee, Byung-Hoon
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating the lysosomal degradation of CES1 (carboxylesterase 1), crucial for triglyceride (TG) breakdown in the liver. This study explores whether SORT1 is targeted for degradation by chaperone-mediated autophagy (CMA), a selective protein degradation pathway that directs proteins containing KFERQ-like motifs to lysosomes via LAMP2A (lysosomal-associated membrane protein 2A). Silencing LAMP2A or HSPA8/Hsc70 with siRNA increased cytosolic SORT1 protein levels. Leupeptin treatment induced lysosomal accumulation of SORT1, unaffected by siLAMP2A co-treatment, indicating CMA-dependent degradation. Human SORT1 contains five KFERQ-like motifs (658VVTKQ662, 730VREVK734, 733VKDLK737, 734KDLKK738, and 735DLKKK739), crucial for HSPA8 recognition; mutating any single amino acid within these motifs decreased HSPA8 binding. Furthermore, compromised CMA activity resulted in elevated SORT1-mediated degradation of CES1, contributing to increased lipid accumulation in hepatocytes. Consistent with in vitro findings, LAMP2A knockdown in mice exacerbated high-fructose diet-induced fatty liver, marked by increased SORT1 and decreased CES1 levels. Conversely, LAMP2A overexpression promoted SORT1 degradation and CES1D accumulation, counteracting fasting-induced CES1D suppression through CMA activation. Our findings reveal that SORT1 is a substrate of CMA, highlighting its crucial role in directing CES1 to lysosomes. Consequently, disrupting CMA-mediated SORT1 degradation significantly affects CES1-dependent TG hydrolysis, thereby affecting hepatic lipid homeostasis. Abbreviations: APOB: apolipoprotein B; CES1: carboxylesterase 1; CMA: chaperone-mediated autophagy; HSPA8/Hsc70: heat shock protein family A (Hsp70) member 8; LAMP2A: lysosomal associated membrane protein 2A; LDL-C: low-density lipoprotein-cholesterol; PLIN: perilipin; SORT1: sortilin 1; TG: triglyceride; VLDL: very low-density lipoprotein; Vps10: vacuolar protein sorting 10.
QUADRILINGUAL SECRETARY FOR INTERPOL - LISTENING SKILLS AND ACTIVE ENGAGEMENT
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Quadrilingual Secretary
Interpol
Multicultural Communication
Cultural Sensitivity
Verbal Communication
Non-verbal Communication
Conflict Resolution
Professional Writing
Public Speaking
International Cooperation

description: In the dynamic and multicultural environment of Interpol, the role of a quadrilingual secretary is pivotal in ensuring seamless communication across diverse linguistic and cultural landscapes. This article explores the essential communication skills required for success in this position, including verbal and non-verbal communication, professional writing, public speaking, active listening, negotiation, conflict resolution, and relationship-building. Emphasizing the importance of cultural sensitivity and adaptability, the article illustrates how mastery of these skills enables the secretary to effectively support international operations, facilitate cooperation, and contribute to global security efforts. Through a comprehensive analysis, the article underscores the significance of communication in navigating complex, high-stakes situations at Interpol.
Supplemental Material, TS2_TPX_10.1177_0192623318765392 - Pathological and Clinical Pathological Changes Induced by Four-week, Repeated-dose, Oral Administration of the Wood Preservative Chromated Copper Arsenate in Wistar Rats
Creators: name: Naofumi Takahashi
name: Yoshida, Toshinori
name: Kojima, Sayuri
name: Yamaguchi, Satoru
name: Ohtsuka, Ryoichi
name: Makio Takeda
name: Kosaka, Tadashi
name: Harada, Takanori
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, TS2_TPX_10.1177_0192623318765392 for Pathological and Clinical Pathological Changes Induced by Four-week, Repeated-dose, Oral Administration of the Wood Preservative Chromated Copper Arsenate in Wistar Rats by Naofumi Takahashi, Toshinori Yoshida, Sayuri Kojima, Satoru Yamaguchi, Ryoichi Ohtsuka, Makio Takeda, Tadashi Kosaka, and Takanori Harada in Toxicologic Pathology
Supplemental_tables - Thirty-Day and 5-Year Readmissions following First Psychiatric Hospitalization: A System-Level Study of Ontario’s Psychiatric Care
Creators: name: Chen, Sheng
name: Collins, April
name: A. Kidd, Sean
Publisher: name: SAGE Journals
Year: 2018
Subjects: Psychiatry (incl. Psychotherapy)
Psychology not elsewhere classified

description: Supplemental_tables for Thirty-Day and 5-Year Readmissions following First Psychiatric Hospitalization: A System-Level Study of Ontario’s Psychiatric Care by Sheng Chen, April Collins and Sean A. Kidd in The Canadian Journal of Psychiatry
Supplementary document for CCS-UNet: a cross-channel spatial attention model for accurate retinal vessel segmentation - 6522243.pdf
Creators: name: Zhu, Yongfei
name: Xu, Xiang
name: Zhang, Xuedian
name: Jiang, Minshan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: List of variables
MoonSupplementalMaterial – Supplemental material for Religious People Are Trusted Because They Are Viewed as Slow Life-History Strategists
Creators: name: Moon, Jordan W.
name: Krems, Jaimie Arona
name: Cohen, Adam B.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, MoonSupplementalMaterial for Religious People Are Trusted Because They Are Viewed as Slow Life-History Strategists by Jordan W. Moon, Jaimie Arona Krems and Adam B. Cohen in Psychological Science
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease
Creators: name: Liu, Qian
name: Wang, Xin
name: Fang, Zhi-Ting
name: Zhao, Jun-Ning
name: Rui, Xue-Xiang
name: Zhang, Bing-Ge
name: He, Ye
name: Liu, Rui-Juan
name: Chen, Jian
name: Chai, Gao-Shang
name: Liu, Gong-Ping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Alzheimer disease (AD), a prevalent neurodegenerative condition in the elderly, is marked by a deficit in macroautophagy/autophagy, leading to intracellular MAPT/tau accumulation. While ISG15 (ISG15 ubiquitin like modifier) has been identified as a regulator of selective autophagy in ataxia telangiectasia (A-T), its role in AD remains unexplored. Our study reveals elevated ISG15 levels in the brains of patients with sporadic AD and AD models in vivo and in vitro. ISG15 overexpression in cells and the hippocampus inhibited HDAC6 (histone deacetylase 6) activity through C-terminal LRLRGG binding to HDAC6. Consequently, this increased CTTN (cortactin) acetylation, disrupted CTTN and F-actin recruitment to lysosomes, and impaired autophagosome (AP)-lysosome (LY) fusion. These disruptions led to MAPT/tau accumulation, synaptic damage, neuronal loss, and cognitive deficits. Conversely, ISG15 knockdown in our HsMAPT (human MAPT) pathology model restored HDAC6 activity, promoted AP-LY fusion, and improved cognitive function. This study identifies ISG15 as a key regulator of autophagic flux in AD, suggesting that targeting ISG15-mediated autophagy could offer therapeutic potential for AD.Abbreviation: AAV: adeno-associated virus; AD: Alzheimer disease; ALP: autophagy-lysosomal pathway; ANOVA: analysis of variance; AP: autophagosome; BafA1: bafilomycin A1; CHX: cycloheximide; CQ: chloroquine; CTTN: cortactin; FC: fear conditioning; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GRIN/NMDARs: N-methyl-D-aspartate glutamate ionotropic receptor NMDA types; HDAC6: histone deacetylase 6; HEK293: human embryonic kidney 293; HsMAPT: human MAPT; IF: immunofluorescence; IHC: immunohistochemistry; IP: immunoprecipitation; ISG15: ISG15 ubiquitin like modifier; LAMP1: lysosomal associated membrane protein 1; LY: lysosome; MAPT: microtubule associated protein tau; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MWM: Morris water maze; NOR: novel object recognition; SQSTM1/p62: sequestosome 1; ZnF UBP: zinc finger ubiquitin-binding protein.
FAI762113_ICMJE – Supplemental material for Correlation of Clinical Evaluation and Radiographic Hindfoot Alignment in Stage II Adult-Acquired Flatfoot Deformity
Creators: name: Netto, Cesar De Cesar
name: Kunas, Grace C.
name: Soukup, Dylan
name: Marinescu, Anca
name: Ellis, Scott J.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110323 Surgery
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, FAI762113_ICMJE for Correlation of Clinical Evaluation and Radiographic Hindfoot Alignment in Stage II Adult-Acquired Flatfoot Deformity by Cesar de Cesar Netto, Grace C. Kunas, Dylan Soukup, Anca Marinescu, and Scott J. Ellis in Foot & Ankle International
Online_supplement_Table_3_Clinical_Guidelines_of_Germany – Supplemental material for Quality Measurement Recommendations Relevant to Clinical Guidelines in Germany and the United Kingdom: (What) Can We Learn From Each Other?
Creators: name: Petzold, Thomas
name: Deckert, Stefanie
name: Williamson, Paula R.
name: Schmitt, Jochen
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Online_supplement_Table_3_Clinical_Guidelines_of_Germany for Quality Measurement Recommendations Relevant to Clinical Guidelines in Germany and the United Kingdom: (What) Can We Learn From Each Other? by Thomas Petzold, Stefanie Deckert, Paula R. Williamson, and Jochen Schmitt in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
Supplementary Table 2 -Supplemental material for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury
Creators: name: Kang, Xue-Jing
name: Chi, Ye-Nan
name: Chen, Wen
name: Liu, Feng-Yu
name: Cui, Shuang
name: Liao, Fei-Fei
name: Cai, Jie
name: Wan, You
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Aged Health Care

description: Supplemental material, Supplementary Table 2 for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury by Xue-Jing Kang, Ye-Nan Chi, Wen Chen, Feng-Yu Liu, Shuang Cui, Fei-Fei Liao, Jie Cai and You Wan in Molecular Pain
Autophagy controls neuronal differentiation by regulating the WNT-DVL signaling pathway
Creators: name: Vidyawan, Vincencius
name: Puspita, Lesly
name: Juwono, Virginia Blessy
name: Deline, Magdalena
name: Pieknell, Kelvin
name: Chang, Mi-Yoon
name: Lee, Sang-Hun
name: Shim, Jae-Won
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology

description: Macroautophagy/autophagy dysregulation is associated with various neurological diseases, including Vici syndrome. We aimed to determine the role of autophagy in early brain development. We generated neurons from human embryonic stem cells and developed a Vici syndrome model by introducing a loss-of-function mutation in the EPG5 gene. Autophagy-related genes were upregulated at the neuronal progenitor cell stage. Inhibition of autolysosome formation with bafilomycin A1 treatment at the neuronal progenitor cell stage delayed neuronal differentiation. Notably, WNT (Wnt family member) signaling may be part of the underlying mechanism, which is negatively regulated by autophagy-mediated DVL2 (disheveled segment polarity protein 2) degradation. Disruption of autolysosome formation may lead to failure in the downregulation of WNT signaling, delaying neuronal differentiation. EPG5 mutations disturbed autolysosome formation, subsequently inducing defects in progenitor cell differentiation and cortical layer generation in organoids. Disrupted autophagy leads to smaller organoids, recapitulating Vici syndrome-associated microcephaly, and validating the disease relevance of our study. Abbreviations: BafA1: bafilomycin A1; co-IP: co-immunoprecipitation; DVL2: dishevelled segment polarity protein 2; EPG5: ectopic P-granules 5 autophagy tethering factor; gRNA, guide RNA; hESC: human embryonic stem cells; KO: knockout; mDA, midbrain dopamine; NIM: neural induction media; NPC: neuronal progenitor cell; qPCR: quantitative polymerase chain reaction; UPS: ubiquitin-proteasome system; WNT: Wnt family member; WT: wild type.
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in alzheimer disease
Creators: name: Liu, Qian
name: Wang, Xin
name: Fang, Zhi-Ting
name: Zhao, Jun-Ning
name: Rui, Xue-Xiang
name: Zhang, Bing-Ge
name: He, Ye
name: Liu, Rui-Juan
name: Chen, Jian
name: Chai, Gao-Shang
name: Liu, Gong-Ping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Cell Biology
Molecular Biology
Neuroscience
Biotechnology
Science Policy
Mental Health
Hematology

description: Alzheimer disease (AD), a prevalent neurodegenerative condition in the elderly, is marked by a deficit in macroautophagy/autophagy, leading to intracellular MAPT/tau accumulation. While ISG15 (ISG15 ubiquitin like modifier) has been identified as a regulator of selective autophagy in ataxia telangiectasia (A-T), its role in AD remains unexplored. Our study reveals elevated ISG15 levels in the brains of patients with sporadic AD and AD models in vivo and in vitro. ISG15 overexpression in cells and the hippocampus inhibited HDAC6 (histone deacetylase 6) activity through C-terminal LRLRGG binding to HDAC6. Consequently, this increased CTTN (cortactin) acetylation, disrupted CTTN and F-actin recruitment to lysosomes, and impaired autophagosome (AP)-lysosome (LY) fusion. These disruptions led to MAPT/tau accumulation, synaptic damage, neuronal loss, and cognitive deficits. Conversely, ISG15 knockdown in our HsMAPT (human MAPT) pathology model restored HDAC6 activity, promoted AP-LY fusion, and improved cognitive function. This study identifies ISG15 as a key regulator of autophagic flux in AD, suggesting that targeting ISG15-mediated autophagy could offer therapeutic potential for AD.
Figure -Supplemental material for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury
Creators: name: Kang, Xue-Jing
name: Chi, Ye-Nan
name: Chen, Wen
name: Liu, Feng-Yu
name: Cui, Shuang
name: Liao, Fei-Fei
name: Cai, Jie
name: Wan, You
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Aged Health Care

description: Supplemental material, Figure for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury by Xue-Jing Kang, Ye-Nan Chi, Wen Chen, Feng-Yu Liu, Shuang Cui, Fei-Fei Liao, Jie Cai and You Wan in Molecular Pain
AUT766572_Supplementary_material – Supplemental material for Functional changes during visuo-spatial working memory in autism spectrum disorder: 2-year longitudinal functional magnetic resonance imaging study
Creators: name: Vogan, Vanessa M
name: Morgan, Benjamin R
name: Smith, Mary Lou
name: Taylor, Margot J
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Education
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, AUT766572_Supplementary_material for Functional changes during visuo-spatial working memory in autism spectrum disorder: 2-year longitudinal functional magnetic resonance imaging study by Vanessa M Vogan, Benjamin R Morgan, Mary Lou Smith and Margot J Taylor in Autism
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression
Creators: name: Mo, Jie
name: Su, Chen
name: Li, Pengcheng
name: Yang, Zhenhua
name: Tao, Ran
name: Liu, Qiumeng
name: Yuan, Chaoyi
name: Xu, Lei
name: Ge, Qianyun
name: Ning, Deng
name: Liang, Huifang
name: Zhu, Haidan
name: Luo, Yan
name: Chen, Xiaoping
name: Chen, Jin
name: Zhang, Bixiang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: RETREG1/FAM134B is known for its role as a reticulophagy receptor. Our previous study established that RETREG1 is upregulated in hepatocellular carcinoma (HCC) and contributes to disease progression by activating the AKT signaling pathway. However, the specific mechanisms underlying the elevated expression of RETREG1 in HCC remain unclear. This study unveils the interaction of RETREG1 with CKAP4 and TRIM21. We demonstrated that TRIM21 ubiquitinates RETREG1 at K247 and K252, facilitating its proteasomal degradation. Conversely, CKAP4 shields RETREG1 from degradation by competitively binding to it, revealing a novel post-translational modification mechanism for RETREG1. By modulating RETREG1 expression, CKAP4, and TRIM21 intricately regulate reticulophagy. Additionally, we observed that stress-induced TRIM21 upregulation mitigates the function of RETREG1 to restore ER stress equilibrium. The oncogenic potential of CKAP4 in HCC was demonstrated using various animal models. Clinical sample analyses suggested that CKAP4 is a potential biomarker for HCC prognosis and diagnosis. Abbreviation: AKT: thymoma viral proto-oncogene; aa: amino acid; bp: base pair; CHX: cycloheximide; co-IP: co-Immunoprecipitation; CQ: chloroquine; CKAP4: cytoskeleton-associated protein 4; DKK1: dickkopf WNT signaling pathway inhibitor 1; DUBs: deubiquitinating enzymes; EBSS: Earle’s balanced salt solution; EGFP: enhanced green fluorescent protein; ER: endoplasmic reticulum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HCC: hepatocellular carcinoma; HFD: high-fat diet; HiTV: hyperdynamic tail vein injection; IF: immunofluorescence; IHC: immunohistochemistry; IP-MS: immunoprecipitation-mass spectrometry; LIR: LC3-interacting region; mAbs: monoclonal antibodies; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; mCherry: monomeric cherry; oe: overexpression; PDX: patient-derived tumor xenograft; reticulophagy: endoplasmic reticulum selective autophagy; RETREG1: reticulophagy regulator 1; RHD: reticulon-homology domain; Tg: thapsigargin; Tm: tunicamycin; TRIM21: tripartite motif-containing 21; UB: ubiquitin; WT: wild-type.
AUT760295_Lay_Abstract – Supplemental material for Scoping the evidence for EarlyBird and EarlyBird Plus, two United Kingdom-developed parent education training programmes for autism spectrum disorder
Creators: name: John-Joe Dawson-Squibb
name: Davids, Eugene Lee
name: Vries, Petrus J De
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Education
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, AUT760295_Lay_Abstract for Scoping the evidence for EarlyBird and EarlyBird Plus, two United Kingdom-developed parent education training programmes for autism spectrum disorder by John-Joe Dawson-Squibb, Eugene Lee Davids and Petrus J de Vries in Autism
Writing Like a Poet: Intimacy and the Instant Message
Creators: name: MILLS, ADELLE LOUISE
Publisher: name: Monash University
Year: 2021
Subjects: classificationCode: 460608
subject: Mobile computing
classificationCode: 500399
subject: Philosophy not elsewhere classified
classificationCode: 360499
subject: Performing arts not elsewhere classified
classificationCode: 360199
subject: Art history, theory and criticism not elsewhere classified

description: Foregrounding the Instant Message as its primary focus, this research project explores the production and expression of intimacy in the contemporary era of networked communication. This research frames the instant message as a dynamic tool for digital communication, situating it within histories of epistolary intimacy, while aspiring to position the instant message as a critical object within visual cultures. As a writing tool shaped by its instantaneity, its proximity to the body, and its variance from social media, the instant message offers meaningful encounters in digital intimacy. While exploring how intimacy emerges through digital writing, my mobile phone—which, like most people’s, goes everywhere with me—has been the object and document of my research, as well as a tool for art production across this project and in the several years preceding.
Modelling and Forecasting Daily cases of COVID19 in Africa, Case study of ECOWAS Countires
Creators: name: Kingdom Nwuju
Publisher: name: figshare
Year: 2020
Subjects: subject: 140305 Time-Series Analysis
subject: FOS: Economics and business

description: A critical investigation into the rate of spread of Coronavirus Disease 2019 (COVID-19) pandemic has shown that, the daily confirmed cases of the disease tend to follow an upward trend. This paper aimed to develop a suitable Autoregressive Integrated Moving Average (ARIMA) model which can be used to statistically forecast the actual number of confirmed cases of COVID-19 recorded in ECOWAS as a whole. An adequate subset ARIMA (5, 1, 1) model is fitted and discussed. A forecast of 235 days from 11th May 2020 to 31st December 2020, was carried out using the fitted model, and we discovered that the COVID-19 daily confirmed cases may most likely incline over the next six months.
AUT766247_Lay_Abstract – Supplemental material for Computer vision analysis captures atypical attention in toddlers with autism
Creators: name: Campbell, Kathleen
name: Carpenter, Kimberly LH
name: Hashemi, Jordan
name: Espinosa, Steven
name: Marsan, Samuel
name: Borg, Jana Schaich
name: Zhuoqing Chang
name: Qiu, Qiang
name: Saritha Vermeer
name: Adler, Elizabeth
name: Tepper, Mariano
name: Egger, Helen L
name: Baker, Jeffery P
name: Sapiro, Guillermo
name: Dawson, Geraldine
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Education
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, AUT766247_Lay_Abstract for Computer vision analysis captures atypical attention in toddlers with autism by Kathleen Campbell, Kimberly LH Carpenter, Jordan Hashemi, Steven Espinosa, Samuel Marsan, Jana Schaich Borg, Zhuoqing Chang, Qiang Qiu, Saritha Vermeer, Elizabeth Adler, Mariano Tepper, Helen L Egger, Jeffery P Baker, Guillermo Sapiro and Geraldine Dawson in Autism
Supplemental Material, ONLINE_APPENDIX_20170305_FINAL - Responsiveness, support, and responsibility: How democratic responsiveness facilitates responsible government
Creators: name: Linde, Jonas
name: Peters, Yvette
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, ONLINE_APPENDIX_20170305_FINAL for Responsiveness, support, and responsibility: How democratic responsiveness facilitates responsible government by Jonas Linde and Yvette Peters in Party Politics
JEA_103-2_Enmarch_Ibis_hieroglyph – Supplemental material for The Son of a Chief of Sculptors Thutmose at Hatnub
Creators: name: Enmarch, Roland
name: Gourdon, Yannis
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: 200299 Cultural Studies not elsewhere classified
subject: FOS: Other humanities

description: Supplemental material, JEA_103-2_Enmarch_Ibis_hieroglyph for The Son of a Chief of Sculptors Thutmose at Hatnub by Roland Enmarch and Yannis Gourdon in The Journal of Egyptian Archaeology
Epitome of Education.pdf
Creators: name: Chauhan, Ramesh Singh
Publisher: name: figshare
Year: 2022
Subjects: subject: 50203 Environmental Education and Extension
subject: FOS: Earth and related environmental sciences

description: Today human society stands at an important crossroads wherein the path that we take hereon will not only determine our wellbeing but also that of the generations who would inhabit our planet after us. The imbalances between our greed and necessities have led to grave ecological imbalances. We can either accept this, go ahead with things as if it is business as usual, or we can take corrective actions. The present generation, to ensure that our coming generations inherit a clean planet. He called for sustainable consumption so that the world does not face a resource crunch. Climate change has become a matter of grave concern after Rio Declaration-1992 due to its potential impacts on earth’s ecosystem. Natural systems are vulnerable to climate change because of their limited adaptive capacity. The natural systems which are vulnerable include glaciers, tropical forests, mangrove, alpine ecosystem, etc. However, man has modified and altered the natural system to such an extent that the equilibrium cannot be restored by inbuilt self-regulatory system. Consequently, the modified environmental conditions adversely affect the functioning of sub-systems. Presently, the adverse effects of modified environmental system are so rapid that biological communities and other physical processes are not able to keep pace with these modifications. Environmental sustainability, the long-term management and protection of earth’s resources and ecosystems, is increasingly recognized as a societal challenge shaped by human behavior at every level of social interaction, from neighborhoods to nations. Psychological perspectives on conservation have traditionally emphasized individual determinants of pro-environmental behavior. But it is well accepted now to incorporate more ways in which both individual and group-level processes can influence conservation efforts. It is significant to incorporate cross cultural perspectives and insights from diversity science and intervention science to understand how different cultural orientations and social identity processes, such as those related to race, ethnicity, and social class, impact environmental decision making. This paper reviews the psychological processes with the emergence of environmental conservation and focus on the problem of conservation as a human cooperative dilemma. It concludes with a consideration of how social psychological perspectives can inform the development of behavioral interventions designed to increase environmental conservation. It also focuses on conservation psychology to highlight its historical and emphasize on behaviors aimed at minimizing human impacts on the natural environment.
Appendix_2_online_supp – Supplemental material for Individual Value Clarification Methods Based on Conjoint Analysis: A Systematic Review of Common Practice in Task Design, Statistical Analysis, and Presentation of Results
Creators: name: Weernink, Marieke G. M.
name: Til, Janine A. Van
name: Witteman, Holly O.
name: Fraenkel, Liana
name: IJzerman, Maarten J.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Appendix_2_online_supp for Individual Value Clarification Methods Based on Conjoint Analysis: A Systematic Review of Common Practice in Task Design, Statistical Analysis, and Presentation of Results by Marieke G. M. Weernink, Janine A. van Til, Holly O. Witteman, Liana Fraenkel and Maarten J. IJzerman in Medical Decision Making
DS_10.1177_0272989X18759488 – Supplemental material for Incorporating Genuine Prior Information about Between-Study Heterogeneity in Random Effects Pairwise and Network Meta-Analyses
Creators: name: Shijie Ren
name: Oakley, Jeremy E.
name: Stevens, John W.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, DS_10.1177_0272989X18759488 for Incorporating Genuine Prior Information about Between-Study Heterogeneity in Random Effects Pairwise and Network Meta-Analyses by Shijie Ren, Jeremy E. Oakley, and John W. Stevens in Medical Decision Making
BloemSupplementalMaterial – Supplemental material for Visual Memories Bypass Normalization
Creators: name: Bloem, Ilona M.
name: Watanabe, Yurika L.
name: Kibbe, Melissa M.
name: Ling, Sam
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, BloemSupplementalMaterial for Visual Memories Bypass Normalization by Ilona M. Bloem, Yurika L. Watanabe, Melissa M. Kibbe, and Sam Ling in Psychological Science
Supplemental material for Real-world management of juvenile autoimmune liver disease
Creators: name: Y S De Boer
name: R Liberal
name: D Vergani
name: G Mieli-Vergani
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material for Real-world management of juvenile autoimmune liver disease by Y S de Boer, R Liberal, D Vergani and G Mieli-Vergani; on behalf of the International Autoimmune Hepatitis Group (IAIHG) in United European Gastroenterology Journal
Physiological Biomarkers of the Central Nervous System in fMRI
Creators: name: Frels, Andrew John
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 400304
subject: Biomedical imaging

description: In functional magnetic resonance imaging the primary contrast is blood oxygen level dependent (BOLD) signal, changes of which are caused by a number of factors. Filtering the BOLD signal to the low frequency oscillation (LFO) band (0.01-0.1 Hz) yields the long-term fluctuations in signal from metabolic or systemic changes. A prominent component of the LFO band has been shown to originate from outside the brain, dubbed the systemic LFO (sLFO). Correlating averaged regional sLFO signals acts as an endogenous bolus to track the flow of blood. Shifts between maximal correlation correspond to the relative delay of blood arrival at these regions of interest. This provides a useful and non-invasive method to evaluate blood flow changes.In Sickle Cell Disease (SCD) this method was used to evaluate the abnormal blood flow common within the condition. In healthy patients, the relationship between the brain and its major venous outflow, the superior sagittal sinus (SSS), was normal with the SSS lagging. However, it was found that in all SCD individuals there was also a leading signal, possibly suggesting two pathways for blood to reach the SSS. These are hypothesized to be a normal pathway through the capillary bed and an alternative shunted pathway wherein blood flow bypasses the capillary bed and highly oxygenated blood reaches the venous system. Novelly, the magnitude of this shunted pathway signal increased with disease severity, implying a novel biomarker for SCD progression.Similarly, the hemodynamic relationship between the brain and spinal cord, an under-investigated topic, was assessed using sLFO techniques. It was found that the brain-spinal cord relationship is comprised of two distinct signals, one with the spinal cord leading the brain and one with it lagging. The early signal is proposed to be carried by arterial flow, reaching the spinal cord before the brain. The late path is believed to be outflow from the brain via the vertebral venous plexus, a network of veins connecting the lower brain to the cervical spine. This could provide a valuable biomarker for vascular damage in spinal cord injury.
Appendix -Supplemental material for Naphtha storage fraction and green house gas emissions in the Korean petrochemical industry
Creators: name: Hi-Chun Park
name: Patel, Martin K
Publisher: name: Figshare
Year: 2018
Subjects: Geography

description: Supplemental material, Appendix for Naphtha storage fraction and green house gas emissions in the Korean petrochemical industry by Hi-Chun Park and Martin K Patel in Energy & Environment
Enhanced Energy Absorption in Hierarchical Honeycomb Structures Using Foaming Materials: Design, Fabrication, and Characterization via Fused Filament Fabrication
Creators: name: Yuan, Haoyang
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 340309
subject: Theory and design of materials
classificationCode: 401799
subject: Mechanical engineering not elsewhere classified

description: This thesis investigates the design, fabrication, and mechanical properties of hierarchical honeycomb structures via the Fused Filament Fabrication (FFF) process. A novel hierarchical design method has been proposed in micro-, meso-, and macro-scale for tailoring relative densities and mechanical properties. The combination of foaming PLA and solid PLA enhances the advantages of honeycomb structures, addressing the shortcomings of traditional designs in terms of mechanical performance and energy absorption capability.
Online_supplemental_table_1 – Supplemental material for Revisiting the Housing–Health Relationship for HIV-Positive Persons: Qualitative Evidence From the Lower Manya Krobo District, Ghana
Creators: name: Teye-Kau, Mabel
name: Tenkorang, Eric Y.
name: Adjei, Paul B.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Online_supplemental_table_1 for Revisiting the Housing–Health Relationship for HIV-Positive Persons: Qualitative Evidence From the Lower Manya Krobo District, Ghana by Mabel Teye-kau, Eric Y. Tenkorang, and Paul B. Adjei in Qualitative Health Research
Investigating the Inverted–U Relationship between Cognitive Performance and Plasma Epinephrine: A Registered Report of a Four-arm Crossover Randomized Controlled Trial
Creators: name: Lin, Ting-Yu
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Sports Sciences
subject: Other Psychiatry and Psychology
subject: Cognitive Neuroscience
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Psychiatry and Psychology
subject: Exercise Physiology
subject: Medicine and Health Sciences
subject: Life Sciences
subject: Biological Psychology
subject: Cognitive Psychology
subject: Neuroscience and Neurobiology
subject: Cognition and Perception
subject: Biochemistry, Biophysics, and Structural Biology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Abstract Although acute resistance exercise has been suggested to enhance inhibitory control, a critical component of executive function, the mechanism by which acute exercise influences inhibitory control is unclear and there are methodological limitations in previous empirical studies. According to the locus coeruleus–norepinephrine (LC–NE) theory, the activity of the LC, the major releaser of NE in the brain, regulates inhibitory control. Because there is reciprocal communication between circulating epinephrine and the LC. Plasma epinephrine is chosen as the index of LC–NE activity. However, only one study in acute exercise–inhibitory control measured the plasma epinephrine. Therefore, this registered report aims to extend its findings by a four–arm crossover randomized controlled design with three different intensities, using free–weight, multiple–joint, and structural resistance exercises. Moreover, most studies showed some methodological limitations such as failing to report the process of randomization, implementing a familiarization of resistance exercise before the maximal strength test, and publishing the protocol. Without a transparent report on how the participants were allocated, the results were at risk of bias. Without a familiarization of resistance exercise, the maximal muscle strength was likely to be underestimated. Without publishing the protocol before data collection, these findings were threatened by undetected researchers’ degrees of freedom such as HARKing (hypothesizing after the results are known), cherry picking, and p–hacking. This registered report will address the limitations of previous studies by incorporating cognitive and resistance exercise familiarization, transparently reporting the randomization process, and submitting it as a registered report.
Pescosolido_et_al._SJPH_Appendix_Tables_3.8.17_Bonferonni – Supplemental material for Icelandic inclusion, German hesitation and American fear: A cross-cultural comparison of mental-health stigma and the media
Creators: name: Manago, Bianca
name: Pescosolido, Bernice A
name: Olafsdottir, Sigrun
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Pescosolido_et_al._SJPH_Appendix_Tables_3.8.17_Bonferonni for Icelandic inclusion, German hesitation and American fear: A cross-cultural comparison of mental-health stigma and the media by Bianca Manago, Bernice A Pescosolido & Sigrun Olafsdottir in Scandinavian Journal of Public Health
Supplemental_materials_online_supp – Supplemental material for Political Gender Stereotypes in a List-PR System with a High Share of Women MPs: Competent Men versus Leftist Women?
Creators: name: Devroe, Robin
name: Wauters, Bram
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, Supplemental_materials_online_supp for Political Gender Stereotypes in a List-PR System with a High Share of Women MPs: Competent Men versus Leftist Women? by Robin Devroe and Bram Wauters in Political Research Quarterly
DS_10.1177_0001839218769634 – Supplemental material for Multinational Firms, Labor Market Discrimination, and the Capture of Outsider’s Advantage by Exploiting the Social Divide
Creators: name: Siegel, Jordan
name: Pyun, Lynn
name: B. Y. Cheon
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, DS_10.1177_0001839218769634 for Multinational Firms, Labor Market Discrimination, and the Capture of Outsider’s Advantage by Exploiting the Social Divide by Jordan Siegel, Lynn Pyun and B. Y. Cheon in Administrative Science Quarterly
Community Event zur Lernzielmatrix 2024: Anwendungsbeispiel – Data Train Anpassungen im Rahmen von DataNord
Creators: name: Maya, Dalby
name: Tanja, Hörner
Publisher: name: Zenodo
Year: 2024

description: Das "Data Train" Programm bietet interdisziplinäres Training in Forschungsdatenmanagement und Data Science. Dieses Programm ist Teil des interdisziplinären Datenkompetenzzentrums DataNord und wurde im Rahmen der U Bremen Research Alliance entwickelt. Es umfasst verschiedene Tracks, wie den "Starter Track", "Data Steward" und "Data Scientist" Track, die auf unterschiedliche Lernniveaus und Themenbereiche abzielen. Das Curriculum wird regelmäßig evaluiert und angepasst, um die Anforderungen regionaler Zielgruppen und Forschungsschwerpunkte zu erfüllen. Zur Qualitätssicherung und Standardisierung der Datenkompetenzausbildung wird das Curriculum im Rahmen von DataNord mit internationalen und nationalen Kompetenzrahmenwerken (u. a. mit DINI/nestor’s Lernzielmatrix) abgeglichen.
761666_supp_mat – Supplemental material for Reporting non-adherence in cluster randomised trials: A systematic review
Creators: name: Schadrac C Agbla
name: DiazOrdaz, Karla
Publisher: name: Figshare
Year: 2018
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, 761666_supp_mat for Reporting non-adherence in cluster randomised trials: A systematic review by Schadrac C Agbla and Karla DiazOrdaz in Clinical Trials
CPS758753_Online_Appendix – Supplemental material for The Relevance of Relative Distribution: Favoritism, Information, and Vote Choice in Africa
Creators: name: Carlson, Elizabeth
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, CPS758753_Online_Appendix for The Relevance of Relative Distribution: Favoritism, Information, and Vote Choice in Africa by Elizabeth Carlson in Comparative Political Studies
Supplementary document for Imaging fine structures of the human trabecular meshwork in vivo using a custom design goniolens and OCT gonioscopy - 6523158.pdf
Creators: name: Martins, Alessandra Carmichael
name: Gast, Thomas
name: king, brett
name: Walker, Brittany
name: Sobczak, Marcelina
name: Burns, Stephen
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Ophthalmology and Optometry not elsewhere classified

description: Fabricating an index-matched 3D printed goniolens for high resolution imaging
Supplementary_Table_1_Final - Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison
Creators: name: Ismail, Fatima Y.
name: Gordon-Lipkin, Eliza
name: Huether, Katherine
name: Blair, Iain
name: Szólics, Miklós
name: Alsaadi, Taoufik
name: Aziz, Faisal
name: Suleiman, Jehan
name: Schiess, Nicoline
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111403 Paediatrics

description: Supplementary_Table_1_Final for Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison by Fatima Y. Ismail, Eliza Gordon-Lipkin, Katherine Huether, Iain Blair, Miklós Szólics, Taoufik Alsaadi, Faisal Aziz, Jehan Suleiman, and Nicoline Schiess in Journal of Child Neurology