cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Subcutaneous inoculation of Escherichia coli in broiler chickens causes cellulitis and elicits innate and specific immune responses
Creators: name: Jonare, Liv
name: Wattrang, Eva
name: Östlund, Emma
name: Wall, Helena
name: Jacobson, Magdalena
name: Jansson, Désirée S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1. Gating strategy for of heterophils, monocytes, lymphocytes, thrombocytes and B-cells in whole blood. Gating strategy to define different leukocyte populations for flow cytometric analysis of leukocyte populations in whole blood using panel 1 (Table 1). Identification of heterophils, monocytes, lymphocytes, thrombocytes, B-cells and counting beads through singlet gating, FSC/SSC characteristics and using CD45-PerCp/Cy5.5, CD41/61-Fitc, KUL01-PE (MRC1L-B) and Bu-1-pacific blue. From the initial dot-plot in A, beads were identified as high Fitc and high PE in B. From A singlet gating (FSC-H vs FSC-A) was performed in C. From the singlet gate in C, CD45 high and CD45 intermediate/SSC low events were gated in D. From the gate in D, the SSC high events were gated in E and from this gate CD45 high/PE low events were gated in F and back-gated as heterophils (high SSC) in G. From the gate in D, thrombocytes (CD41/61 positive) and KUL01 positive events were gated in H. From the KUL01 gate in H, events were gated as monocytes based on FSC/SSC characteristics in I. Non-thrombocyte events in H were gated on FSC low/SSC low profile as lymphocytes in J. From the CD45 gate in D Bu-1 positive events were gated in K and the Bu-1 positive events were gated as B-cells based on FSC/SSC characteristics in L. A representative chicken blood sample from a B group chicken (no. 37) on day 1 is shown
Nonhoff, Winfried (Hrsg.): Amen, so sei es
Creators: name: Jockwig, Klemens
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
Monkeypox in a Patient with Controlled HIV Infection Initially Presenting with Fever, Painful Pharyngitis, and Tonsillitis
Creators: name: Fischer, Fabian
name: Mehrl, Alexander
name: Kandulski, Melanie
name: Schlosser, Sophie
name: Müller, Martina
name: Schmid, Stephan
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: ; monkeypox; fever; pharyngitis; tonsillitis; HIV
subject: 610 Medizin

description: Background and Objectives: With more and more cases emerging outside central and west African countries, where the disease is endemic, the World Health Organization (WHO) has recently declared human monkeypox a Public Health Emergency of International Concern. Typical symptoms of the disease include fever, myalgia, and lymphadenopathy followed by a rash, but other symptoms may occur. Immunocompromised patients, including patients with uncontrolled Human Immunodeficiency Virus (HIV) infection, may be at risk for more severe courses. Case presentation: We present the case of a 30-year-old male patient of Brazilian descent with monkeypox. Initial symptoms were fever and general discomfort, with painful pharyngitis and tonsillitis and finally a papular rash of the anogenital area as the disease progressed. The presumed date of infection was a sexual contact with an unknown male eight days before the first symptoms occurred. The patient had a known and controlled HIV infection. The main reason for the initial presentation at the hospital was painful pharyngitis and tonsillitis, limiting food intake. Monkeypox infection was confirmed via PCR testing from a swab sample of cutaneous lesions. Adequate systemic and local analgesia enabled oral food uptake again. Antiviral therapy with Tecovirimat was not administered due to the stable immune status of the patient and the mild clinical symptoms. To cover a possible bacterial superinfection or Syphilis infection of the tonsil, antibiotic therapy with Ceftriaxone was added. Several days after presentation, the inflammation of the pharynx resolved and was followed by non-painful mucosal peeling. The patient was followed up with telephone calls and reported a complete recovery. The skin lesions were completely dried out 18 days after the first symptoms. Conclusions: Painful pharyngitis and tonsillitis can be rare early symptoms of monkeypox, which is highly relevant in everyday clinical practice. Particularly in patients with risk factors for monkeypox infection, further clinical and microbiologic testing for monkeypox should be performed if there is a clinical presentation with pharyngitis and tonsillitis.
title: Establishing a relationship between particle size distribution & thaw weakening susceptibility in soils
Creators: name: Leak, James
name: Dimitriadi, Vasiliki
name: Barreto, Daniel
name: Bernal-Sanchez, Juan
name: Imre, Emöke
Publisher: name: Strathprints - University of Strathclyde
Year: 2025

description: Susceptibility to frost action in soils is an important consideration in cold and seasonably cold regions. Whilst the particle size distribution (PSD) is commonly used to measure susceptibility to frost action, this method is typically seen as unreliable. Moreover, susceptibility criteria are generally specific to frost heave despite heave and thaw weakening both being described by the term frost action. Therefore, the effect of PSD on thaw weakening has not been fully explored. This study sets out to establish a relationship between PSD and thaw weakening susceptibility considering a better set of PSD descriptors than those traditionally used (e.g. d50, Cu and Cc) towards the entire PSD. By examining available experimental data in the literature, in particular studies used to establish existing thaw weakening susceptibility criteria and testing set out in ASTM D5918–13, it was found that PSD influences thaw weakening susceptibility. PSDs located to the right of the stability line in the normalised entropy diagram (used to characterise PSDs) were found to be largely non-susceptible, whereas finer PSDs to the left the stability line were found to be highly susceptible to thaw weakening. It was also found that PSD greatly affects changes in bearing capacity after thawing. The analyses presented here demonstrate that the grading entropy stability criteria has significant potential as a method of predicting thaw weakening susceptibility.
Cell-Enriched Lipotransfer (CELT) Improves Tissue Regeneration and Rejuvenation without Substantial Manipulation of the Adipose Tissue Graft
Creators: name: Prantl, Lukas
name: Eigenberger, Andreas
name: Reinhard, Ruben
name: Siegmund, Andreas
name: Heumann, Kerstin
name: Felthaus, Oliver
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: fat grafting; lipofilling; mesenchymal stem cells; adipose tissue-derived stem cells; regeneration; regenerative medicine; reconstructive surgery
subject: 610 Medizin

description: The good availability and the large content of adult stem cells in adipose tissue has made it one of the most interesting tissues in regenerative medicine. Although lipofilling is one of the most frequent procedures in plastic surgery, the method still struggles with high absorption rates and volume losses of up to 70%. Therefore, many efforts have been made to optimize liposuction and to process the harvested tissue in order to increase fat graft retention. Because of their immunomodulatory properties, their cytokine secretory activity, and their differentiation potential, enrichment with adipose tissue-derived stem cells was identified as a promising tool to promote transplant survival. Here, we review the important parameters for lipofilling optimization. Finally, we present a new method for the enrichment of lipoaspirate with adipose tissue-derived stem cells and discuss the parameters that contribute to fat graft survival.
Does recognition matter? Exploring patron penetration of de-facto state structures
Creators: name: Blakkisrud, Helge
name: Gelashvili, Tamta
name: Kemoklidze, Nino
name: Kolstø, Pål
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Physical Sciences not elsewhere classified
Medicine
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: De facto states seek international recognition. But do patron states that extend such recognition to their de-facto state clients treat them differently than they would have done otherwise? Will patrons, having extended official recognition, be more inclined to treat their clients as ‘regular’ states? Or does recognition only make the client more beholden to the patron? To investigate this, we explore whether granting recognition affects the degree of patron-state penetration of two sectors critical to the de facto state for retaining (internal) sovereignty and agency: the executive branch, and the military.
Trichoplusia
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Trichoplusia

description: Trichoplusia ni (Hübner, [1803])
(Fig. 2)
Material examined. Wolaita Zone, Sodo. 2000 m. VIII.2011. Leg. Kravchenko V.
Literature. Behounek & Ronkay 1989; Behounek et al. 2010; Dufay 1970; Dufay & Laporte 1977; Goater et al. 2003; Lafontaine & Poole 1991; Pinhey 1975; Wiltshire 1990.
General distribution pattern. Throughout the southern Palearctic region including the Mediterranean basin, Levant and most of the Indo-Pacific region. Throughout Africa including in oases located in desert habitats. Also common in the Nearctic and Neotropical regions.
Distribution in Ethiopia. Throughout the country. In the arid region, concentrated in oases. Abundant.
Host plants. Polyphagous on numerous herbaceous plants including garden flowers, vegetables and melons.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 236, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
title: Toujours plus de murs dans un "monde sans frontières"
title: More and more walls in a "world of open borders"
titleType: AlternativeTitle
Creators: name: Lambert, Nicolas
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: frontière
subject: migration
subject: immigration
subject: mur
subject: libre circulation
subject: barrière économique
subject: clôture
subject: conflit territorial
subject: zone de conflit

description: Carte présentée dans la première partie de l'Atlas des migrants en Europe : Des migrations mondialisées mais entravées - Quatrième sous-partie : Difficiles libertés de circulation
description: Source: Origine des données : Élisabeth Vallet, Chaire Raoul-Dandurand, UQAM et compilation, 2011.
description: Relation: https://www.nakala.fr/data/11280/9400d78f
description: Relation: https://www.nakala.fr/data/11280/501a20b0
description: Relation: https://www.nakala.fr/data/11280/50615426
description: Coverage: Monde
description: Cette carte décrit les murs, barrières et clôtures dans le monde en 2011. A cette date, il y avait 48 murs recensés dans le monde, souvent construits dans le but d’empêcher les migrations (en rouge sur la carte). Au total, ces murs représentent plus de 30 000 kilomètres linéaire. Un graphique adossé à la carte nous apprend également que le nombre de murs, barrières et clôtures dans le monde a triplé depuis la chute du mur de Berlin. Toujours plus de murs dans un monde sans frontières…
description: Temporal: start=1945; end=2011;
description: Bibliographic citation: LAMBERT, Nicolas. Toujours plus de murs dans un "monde sans frontières" [carte].In MIGREUROP. Atlas des migrants en Europe. Géographie critique des politiques migratoires.Paris: Armand Colin Atlas Editeur, 2012. P. 25
Abrawayaomys Souza Cunha and Cruz 1979
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Abrawayaomys

description: Abrawayaomys Souza Cunha and Cruz 1979
Abrawayaomys Souza Cunha and Cruz 1979, Bol. Mus. Biol. Prof. Mello-Leitao Zool., 96: 2.
Type Species: Abrawayaomys ruschii Cunha and Cruz 1979
Species and subspecies: 1 species:
Species Abrawayaomys ruschii Cunha and Cruz 1979
Discussion: Sigmodontinae incertae sedis. Diagnostic traits seem to combine aspects of Neacomys, Oryzomys, and Akodon, and both Reig (1987) and Smith and Patton (1999) acknowledged the enigmatic affinities of Abrawayaomys as uncertain. Certain cranial features of Abrawayaomys suggest an archaic "thomasomyine," perhaps distantly related to the other endemic genera of SE Brazil (e.g., see comments under Delomys).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1088, DOI: 10.5281/zenodo.7316535
Foliaro nº 20 (Japanio nº6 Ĉinio nº1) (p. 24)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Gravaj P.N. antaŭforlasi Japanion en 1930a.
Treatment of Periprosthetic Joint Infection and Fracture-Related Infection With a Temporary Arthrodesis Made by PMMA-Coated Intramedullary Nails – Evaluation of Technique and Quality of Life in Implant-Free Interval
Creators: name: Walter, Nike
name: Baertl, Susanne
name: Lang, Siegmund
name: Szymski, Dominik
name: Weber, Johannes
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: EUROQOL; COMBINATION; NONUNIONS; TITANIUM; SPACERS; polymethyl methacrylate (PMMA); coated implants; temporary arthrodesis; quality of life; psychological outcomes; periprosthetic joint infection; fracture-related infection
subject: 610 Medizin

description: Background: Antimicrobial coating of intramedullary nails with polymethyl methacrylate (PMMA) bone cement promises infection control and stabilization for subsequent bone healing. However, when removing the implant, bone cement can debond and remain in the medullary cavity of the long bones, representing a nidus for reinfection. This work presents a technique comprising reinforcement of PMMA-coated intramedullary nails with cerclage wire to prevent such problems in patients treated for fracture-related infection (FRI) or knee periprosthetic joint infection (PJI) with a static spacer as temporary arthrodesis allowing weight-bearing in the implant-free interval. Outcomes of this surgical treatment were evaluated in terms of (i) associated complications and (ii) patient-reported quality of life. Methods: In this retrospective case series, 20 patients with PJI (n = 14, 70%) and FRI (n = 6, 30%) treated with PMMA-coated intramedullary nails reinforced with cerclage wire between January 2021 and July 2021 were included. Quality of life during the implant-free interval was evaluated with the EQ-5D, SF-36, and an ICD-10 based psychological symptom rating and compared with previously analyzed cohorts of successfully treated PJI and FRI patients in whom eradication of infection and stable bone consolidation was achieved. Results: Complications during the implant-free interval comprised a broken nail in one case (5.0%) and a reinfection in one case (5.0%). Coating-specific side effects and cement debonding during removal did not occur. The mean physical health component score of SF-36 was 26.1 +/- 7.6, and the mean mental health component score reached a value of 47.1 +/- 18.6. The mean EQ-5D index value was 0.36 +/- 0.32 and the mean EQ-5D visual analogue scale rating was 47.4 +/- 19.4. The scores were significantly lower than those in the successfully treated FRI cohort but not in the PJI cohort. The mean ICD-10-based symptom rating scores revealed psychological symptom burden on the depression scale and enhanced levels of anxiety in comparison with healed FRI and PJI patients. Conclusion: Reinforcement of PMMA bone cement-coated implants seems to be a reasonable treatment option to create a temporary arthrodesis, preventing detachment of the bone cement when the implant was removed.
Nebria meurguesae Ledoux 1985
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria meurguesae

description: Nebria meurguesae LEDOUx, 1985
Paratypes: 2 ♀, Paratype [red label, printed // Afghan. Kunar (Kouchtous), vallée de l'Ourlah [handwritten] // 2700–3250 m Névé, 21.8.1976, G. Ledoux [handwritten] // N. (Himalayonebria) meurguesae Ledoux [handwritten] (SMNS).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 7, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Lytocarpia spiralis
Creators: name: Galea, Horia R.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Leptothecata
Aglaopheniidae
Lytocarpia
Lytocarpia spiralis

description: Lytocarpia cf. spiralis (Totton, 1930)
Figs 16A, 17 A–B
Thecocarpus spiralis Totton, 1930: 238, fig. 69c–d.
Thecocarpus spiralis – Ralph 1961: 59, figs 8i–j, 10d.
Lytocarpia spiralis – Vervoort & Watson 2003: 321, figs 77d–h, 78a–e.
Material examined
PACIFIC OCEAN • 1 colony, ca 46 cm high, bearing 11 plumose side branches, without gonothecae, hydrothecae with mostly damaged rims; off New Caledonia, stn DW5038; 19°55ʹ S, 158°35ʹ E; 340 m; 22 Sep. 2017; KANADEEP leg.; MNHN-IK-2015-546.
Remarks
The present material agrees well with descriptions of Lytocarpia spiralis (Totton, 1930) by Ralph (1961) and Vervoort & Watson (2003) but, since it is devoid of its gonosome and the condition of the hydrothecal rim could not be assessed properly, it is assigned with a query to it.
Distribution
Previously known from waters around New Zealand (Vervoort & Watson 2003); New Caledonia (present study).
description: Published as part of Galea, Horia R., 2020, Aglaopheniid hydroids (Cnidaria: Hydrozoa: Aglaopheniidae) from off New Caledonia collected during KANACONO and KANADEEP expeditions of the French Tropical Deep-Sea Benthos Program, pp. 1-47 in European Journal of Taxonomy 615 on page 33, DOI: 10.5852/ejt.2020.615, http://zenodo.org/record/3711000
Les conquestes du Marquis de Grana dans les Pays-Bas
Creators: name: de Sandras de Courtilz, Gatien
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Cuir de Rus., filets tranches dorées; Reliure de Purgold
description: Source: Bibliothèque patrimoniale Villon (Rouen). Cote : Leberp-2313
Gottschalk, Joseph: Hedwig von Andechs - Herzogin von Schlesien
Creators: name: Jockwig, Klemens
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain
Creators: name: Kozole, Judith
name: Heydn, Rosmarie
name: Wirkert, Eva
name: Küspert, Sabrina
name: Aigner, Ludwig
name: Bruun, Tim-Henrik
name: Bogdahn, Ulrich
name: Peters, Sebastian
name: Johannesen, Siw
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: WAXHOLM SPACE ATLAS; HIPPOCAMPAL NEUROGENESIS; STEM-CELLS; PROTEIN; FAMILY; brain repair; neurodegeneration; neurogenesis; neuronal stem cells; G-CSF; high-dose G-CSF; cellular brain therapy; cerebellum; filgrastim safety
subject: 610 Medizin

description: The hematopoietic granulocyte-colony stimulating growth factor (G-CSF, filgrastim) is an approved drug in hematology and oncology. Filgrastim's potential in neurodegenerative disorders is gaining increasingly more attention, as preclinical and early clinical studies suggest it could be a promising treatment option. G-CSF has had a tremendous record as a safe drug for more than three decades; however, its effects upon the central nervous system (CNS) are still not fully understood. In contrast to conceptual long-term clinical application with lower dosing, our present pilot study intends to give a first insight into the molecular effects of a single subcutaneous (s.c.) high-dose G-CSF application upon different regions of the rodent brain. We analyzed mRNA-and in some instances-protein data of neurogenic and non-neurogenic differentiation markers in different regions of rat brains five days after G-CSF (1.3 mg/kg) or physiological saline. We found a continuous downregulation of several markers in most brain regions. Remarkably, cerebellum and hypothalamus showed an upregulation of different markers. In conclusion, our study reveals minor suppressive or stimulatory effects of a single exceptional high G-CSF dose upon neurogenic and non-neurogenic differentiation markers in relevant brain regions, excluding unregulated responses or unexpected patterns of marker expression.
Abrawayaomys ruschii Cunha and Cruz 1979
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Abrawayaomys
Abrawayaomys ruschii

description: Abrawayaomys ruschii Cunha and Cruz 1979
Abrawayaomys ruschii Cunha and Cruz 1979, Bol. Mus. Biol. Prof. Mello-Leitao Zool., 96: 2.
Type Locality: Brazil, Espírito Santo, Forno Grande, Castelo.
Vernacular Names: Ruschi's Rat.
Distribution: Known from scattered localities in Espírito Santo and Minas Gerais, Brazil, and Misiones Prov., Argentina (see Massoia et al., 1991).
Conservation: IUCN – Endangered.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1088, DOI: 10.5281/zenodo.7316535
Nebria molendai HUBER & SCHMIDT 2007
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria molendai

description: Nebria molendai HUBER & SCHMIDT, 2007
Holotype ♂: Nepal, Rolwaling valley, Na to Omai Tsho lake, 4100–4500 m, 22.5.2000, leg. Schmidt (NMBE).
Paratypes: 32 specimens same data as holotype (NMBE, cSCHM).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 7, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Real-world study of patients with HR+/ HER2- metastatic breast cancer treated with palbociclib and fulvestrant
Creators: name: Robert, Nicholas
name: Chen, Connie
name: Doan, Justin
name: Venkatasetty, Divea
name: Espirito, Janet L.
name: Aguilar, Kathleen M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: To investigate real-world treatment patterns and outcomes among patients with hormone receptor-positive/human epidermal growth factor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) who initiated first-line palbociclib-fulvestrant. Retrospective observational study of iKnowMed electronic health records among patients who initiated first-line palbociclib-fulvestrant between 1 February 2016 and 31 December 2019 and were followed through 30 June 2020. Demographic, clinical, and treatment characteristics were evaluated descriptively. Endpoints including real-world progression-free survival, overall survival, time to chemotherapy, real-world duration of therapy, and time to next treatment were assessed using Kaplan–Meier methods from first-line treatment initiation. 317 patients were included (median age 67.3 years, 90.5% post-menopausal, 36.9% bone-only disease, 15.9 months median follow-up). Among those with prior adjuvant treatment (n = 269), 66.2% (n = 178) had disease-free intervals less than 12 months. Median real-world progression-free survival was 19.6 months (95% CI 15.2–23.6). These results suggest favorable real-world clinical outcomes associated with first-line palbociclib-fulvestrant among patients with HR+/HER2- mBC. (clinical trial registration: NCT04498481).
Additional file 2 of Subcutaneous inoculation of Escherichia coli in broiler chickens causes cellulitis and elicits innate and specific immune responses
Creators: name: Jonare, Liv
name: Wattrang, Eva
name: Östlund, Emma
name: Wall, Helena
name: Jacobson, Magdalena
name: Jansson, Désirée S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 2. Gating strategy for TCR𝛾/𝛿+ , CD8+ and CD4+ lymphocyte subpopulations in whole blood. Gating strategy for flow cytometric analysis of leukocyte populations in whole blood using panel 2 (Table 1 ). Identification of lymphocyte sub populations TCR𝛾/𝛿+CD8-, TCR𝛾/𝛿+CD8𝛼β + , TCR𝛾/𝛿+CD8𝛼𝛼 + , TCR𝛾/𝛿-CD8𝛼β + (CTL), TCR𝛾/𝛿-CD8𝛼𝛼+ , CD4+CD8-, CD4+CD8𝛼𝛼+ and CD25 expression on some of these as well as counting beads through singlet gating, FSC/SSC characteristics and using CD41/61-Fitc, CD8β-PE, CD8𝛼-Cy5, CD4-pacific blue, TCR1-PerCPCy5.5 and CD25-PECy5. From the initial dot-plot in A, beads were identified as high Fitc and high PE in B. From A singlet gating (FSC-H vs FSC-A) was performed in C. From the singlet gate in C non-thrombocyte events (CD41/61 negative) were identified in D and were gated on a FSC low/SSC low profile as lymphoid in E. Lymphoid events from E were gated as TCR𝛾/𝛿+ in F. TCR𝛾/𝛿+ events were defined according to CD8 expression as TCR𝛾/𝛿+CD8-, TCR𝛾/𝛿+CD8𝛼β + or TCR𝛾/𝛿+CD8𝛼𝛼+ in G and CD25 expression on TCR𝛾/𝛿+CD8- in H. Non-TCR𝛾/𝛿+ events from F were defined according to CD4 expression in I and CD4 positive events defined according to CD8 expression as CD4+CD8- or CD4+CD8𝛼𝛼+ in J and CD25 expression on these populations were defined in K and L. CD4 negative events defined in I were defined according to CD8 expression in M as TCR𝛾/𝛿-CD8𝛼β+ (CTL) or TCR𝛾/𝛿-CD8𝛼𝛼+ and CD25 expression on TCR𝛾/𝛿-CD8𝛼β+ was defined N. The CD4-CD8𝛼𝛼+ , TCR𝛾/𝛿+CD8𝛼𝛼+ and TCR𝛾/𝛿+CD8𝛼β+ populations had very few events (< 77 in mean events) and CD25 expression was therefore not relevant to analyse for these populations. A representative chicken blood sample from a group B chicken (no. 38) on day 1 is shown
Successful Use of Interferon-Gamma for Refractory Disseminated Candida Tropicalis Infection in a Pediatric Patient with Acute Myeloid Leukemia and Heterozygous CARD9 Mutation
Creators: name: Kleinschmidt, Katharina
name: Troeger, Anja
name: Foell, Juergen
name: Jakob, Marcus
name: Corbacioglu, Selim
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: AML; Infections in Immunocompromised Hosts; Immunology; Immunotherapy; Molecular Genetics; Stem Cell Transplantation
subject: 610 Medizin

description: Invasive fungal infections remain among the most frequent severe and fatal complications of oncology, despite effective antifungal agents. Genetic aberrations may additionally increase the individual patient’s susceptibility to invasive mycosis, with the need for an intensified treatment, such as adjunctive immunotherapy combined with standard antifungal medication. Interferon-gamma (IFN-γ) as an immunostimulatory agent may represent a promising surrogate to reactivate the cytotoxic activity of macrophages in patients with ‘blind spots’. We report the case of a pediatric patient with AML and disseminated candida tropicalis infection, bearing a heterozygous CARD9 mutation, who was treated successfully with combined IFN-γ and conventional antifungal therapy.
title: Formation doctorale (2022-2023) – Atelier PGD de sa thèse
Creators: name: Delay-Artous, Cécile
name: Mathelier, Daphné
name: Reymonet, Nathalie
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: science ouverte
subject: données SHS
subject: Doctorat, Thèses de

description: Atelier « PGD de sa thèse » proposée régulièrement durant l’année universitaire 2022-2023 dans le cadre d’une collaboration entre le service Humanités numériques de la MSH Mondes, le service commun de la documentation (SCD) et le service de la formation doctorale de la direction de la recherche et des études doctorales (DRED) de l’Université Paris Nanterre.

Objectif : présenter ce qu'est un PGD et aider les doctorants à rédiger celui de leur thèse
description: Support de l'atelier « Atelier PGD de sa thèse » (2022-2023)
Graphical Introduction to AI Security Risks for Space Applications
Creators: name: Warsaw University of Technology
name: KP Labs
name: European Space Operations Centre
name: European Space Research and Technology Centre
Publisher: name: European Space Agency
Year: 2025
Subjects: subject: Artificial intelligence
subject: Artificial Intelligence
subject: Computer Security
subject: Computer security
subject: Space Research
subject: Space research

description: This document is a graphical introduction and summary of the Catalogue of Security Risks for AI Applications in Space (SAI Catalogue) created as a part of the "PINEBERRY: Explainable, Robust and Secure AI for Demystifying Space Operations" activity funded by the European Space Agency. The full SAI catalogue is accessible for registered users from ESA Member States on the Space CODEV platform. 

The graphical introduction is a user-friendly educational material for anyone working with AI applications in the space domain, but also any other domains where security is a critical issue, e.g., aviation, autonomous driving, defence, energy, medicine, fintech, etc. It contains descriptions of 9 common AI security risks together with their possible mitigations and mapping to existing standards issued by NIST, OWASP, and Snowflake.

More information about the project can be found at its website: https://assurance-ai.space-codev.org/
Soll in klösterlichen oder bischöflichen Internaten der Priesterberuf aktiv angestrebt werden?
Creators: name: Randak, Oskar
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
The relationship between adolescents' externalizing and internalizing symptoms and brain development over a period of three years
Creators: name: Jarvers, Irina
name: Kandsperger, Stephanie
name: Schleicher, Daniel
name: Ando, Ayaka
name: Resch, Franz
name: Koenig, Julian
name: Kaess, Michael
name: Brunner, Romuald
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: DIFFICULTIES QUESTIONNAIRE; CORTICAL THICKNESS; DSM-IV; VOLUME; METAANALYSIS; DISORDERS; CHILDHOOD; BEHAVIORS; STRENGTHS; CHILDREN; Brain development; Psychopathology; Externalizing; Internalizing; Adolescence
subject: 610 Medizin

description: Background: Adolescence is a crucial period for both brain maturation and the emergence of mental health disorders. Associations between brain morphology and internalizing/externalizing symptomatology have been identified in clinical or at-risk samples, but age-related developmental differences were rarely considered. The current study investigated the longitudinal relationship between internalizing/externalizing symptoms and brain development in the absence of psychiatric disorders during early and late adolescence.Methods: 98 healthy adolescents within two cohorts (younger: 9 years, older: 12 years) participated in annual assessments for three years; a clinical assessment measuring their externalizing and internalizing symptoms (SDQ) and an MRI assessment measuring their brain volume and white matter microstructure, including frac-tional anisotropy (FA), mean diffusivity (MD) and average path length.Results: Linear mixed effect models and cross-lagged panel models showed that larger subcortical gray matter volume predicted more externalizing symptoms in older adolescents whereas decreases of subcortical gray matter volume predicted more externalizing symptoms for younger adolescents. Additionally, longer average white matter path length predicted more externalizing symptoms for older adolescents, while decreases in ce-rebral white matter volume were predictive of more externalizing symptoms for younger adolescents. There were no predictive effects for internalizing symptoms, FA or MD.Conclusions: Delays in subcortical brain maturation, in both early and late adolescence, are associated with in-creases in externalizing behavior which indicates a higher risk for psychopathology and warrants further investigations.
Abrothrix Waterhouse 1837
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Abrothrix

description: Abrothrix Waterhouse 1837
Abrothrix Waterhouse 1837, Proc. Zool. Soc. Lond., 1837: 21.
Type Species: Mus longipilis Waterhouse 1837
Synonyms: Chroeomys Thomas 1916; Habrothrix Wagner 1843.
Species and subspecies: 9 species:
Species Abrothrix andinus Philippi 1858
Species Abrothrix hershkovitzi Patterson, Gallardo, and Freas 1984
Species Abrothrix illuteus Thomas 1925
Species Abrothrix jelskii Thomas 1894
Species Abrothrix lanosus Thomas 1897
Species Abrothrix longipilis Waterhouse 1837
Species Abrothrix markhami Pine 1973
Species Abrothrix olivaceus Waterhouse 1837
Species Abrothrix sanborni Osgood 1943
Discussion: Akodontini (S Andean clade). An assemblage of species whose level of taxonomic recognition has come full circle: early employed as a genus (Gyldenstolpe, 1932; Thomas, 1916); later viewed as subgenus of Akodon (Cabrera, 1961; Ellerman, 1941; Musser and Carleton, 1993; Reig, 1978, 1981, 1987) or even a full synonym of Microxus (Hershkovitz, 1966 c); and recently reinstated to genus based on congruence of morphological, karyological, and genetic traits that set it apart from typical Akodon (Apfelbaum and Reig, 1989; Barrantes et al., 1993; Gallardo et al., 1988; Smith and Patton, 1993, 1999; Spotorno et al., 1990). See Reig (1987), Spotorno et al. (1990), and Barrantes et al. (1993) for a review of the treatment of Abrothrix and its specific contents. Sister genus to the long-clawed akodonts (Chelemys, etc.) according to cladistic interpretations of allozymic and cytochrome b data (Barrantes et al., 1993; D’Elía, 2003; D’Elía et al., 2003; Smith and Patton, 1993, 1999).
Working with N species of the S Andean clade (i.e., jelskii and andinus), Patton et al. (1989; and later Smith and Patton, 1991, 1993, and Patton and Smith, 1992) conveyed their genetic divergence and cladistic separation by employing the local genus-group taxon Chroeomys (type species in Perú). Described as a genus (Thomas, 1916 c), Chroeomys, like Abrothrix, was afterwards conventionally viewed as a subgenus of Akodon (Cabrera, 1961; Ellerman, 1941; Gardner and Patton, 1976; Reig, 1987) until the studies of Patton and Smith. Although Smith and Patton (1999) have continued to recognize Chroeomys as a genus (including jelskii but not andinus which they returned to Abrothrix), their own gene-sequence analyses consistently nest jelskii among species of Abrothrix, not basal to them. These results, together with the persuasive body of evidence cited above, recommend the junior synonymy of Chroeomys.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1088, DOI: 10.5281/zenodo.7316535
title: Activité du port de Saint-Malo – 1701 – Brest
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: fruits et légumes
subject: épices et condiments
subject: produits manufacturés
subject: produits laitiers
subject: produits de la mer
subject: poissons
subject: alcool
subject: viande, bétail
subject: minerais et métaux
subject: armes et munitions
subject: matériaux de construction
subject: céréales

description: Marchandises au départ de Saint-Malo : pain ; pois ; poivre ; savon ; huile ; beurre ; morues séchées ; cidre ; vin ; vin d'Espagne ; bière ; boeuf ; fer
description: Catégories de marchandises au départ de Saint-Malo : produits agroalimentaires ; fruits et légumes ; épices et condiments ; produits manufacturés ; produits laitiers ; produits de la mer ; poissons ; alcool ; viande, bétail ; minerais et métaux
description: Marchandises arrivées à Saint-Malo : boulets ; canons ; bombes ; goudron ; sardines ; ardoises ; vin ; riz ; morues séchées ; sel
description: Catégories de marchandises arrivées à Saint-Malo : produits manufacturés ; armes et munitions ; matériaux de construction ; produits de la mer ; poissons ; produits agroalimentaires ; alcool ; céréales ; épices et condiments
description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1701 avec le port "Brest"
description: Coverage: Petit cabotage
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Abrothrix andinus Philippi 1858
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Abrothrix
Abrothrix andinus

description: Abrothrix andinus Philippi 1858
Abrothrix andinus Philippi 1858, Arch. Naturgesch., 23 (1): 77.
Type Locality: Chile, Santiago Prov., Altos Andes.
Vernacular Names: Andean Akodont.
Synonyms: Abrothrix cinnamomea (Philippi 1896); Abrothrix dolichonyx (Philippi 1896); Abrothrix gossei (Thomas 1920); Abrothrix jucundus (Thomas 1913); Abrothrix polius Osgood 1944.
Distribution: Altiplano, generally above 3500 m, from SC Perú, through extreme W Bolivia, to NW Argentina and C Chile (as far as 34ºS; Muñoz Pedreros, 2000).
Conservation: IUCN – Lower Risk (lc) as Chroeomys andinus.
Discussion: Anderson (1997) employed dolichonyx as subspecies for Bolivian populations but emphasized the need for fresh evaluation of intraspecific variation.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1088, DOI: 10.5281/zenodo.7316535
Additional file 4 of Subcutaneous inoculation of Escherichia coli in broiler chickens causes cellulitis and elicits innate and specific immune responses
Creators: name: Jonare, Liv
name: Wattrang, Eva
name: Östlund, Emma
name: Wall, Helena
name: Jacobson, Magdalena
name: Jansson, Désirée S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 4. Summary of findings. Summary of individual general appearance, culture results, outcome and post-mortem findings in control chickens (n=15) and chickens inoculated subcutaneously on experimental day 0 with E. coli strain ECA18 (group A, n=15) or strain ECB11 (group B, n=15). Only chickens with findings are included
Nebria nouristanensis LEDOUx 1985
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria nouristanensis

description: Nebria nouristanensis LEDOUx, 1985
Paratype ♀: Paratype [red label, printed] //Afghan. Kunar Hte. Vallée de l'Agôk Khwar [handwritten] // 3900 m Névé, 23.8.1976, leg. G. Ledoux [handwritten] // N. (Himalayonebria) nouristanensis G. Ledoux [handwritten] (SMNS).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 7, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition
Creators: name: Glehr, Gunther
name: Riquelme, Paloma
name: Yang Zhou, Jordi
name: Cordero, Laura
name: Schilling, Hannah-Lou
name: Kapinsky, Michael
name: Schlitt, Hans J.
name: Geissler, Edward K.
name: Burkhardt, Ralph
name: Schmidt, Barbara
name: Haferkamp, Sebastian
name: Hutchinson, James A.
name: Kronenberg, Katharina
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: ADVANCED MELANOMA; BLOOD-COUNT; IPILIMUMAB; TOXICITY; REGULARIZATION; AUTOIMMUNITY; THERAPY; biomarker; checkpoint inhibition; irAEs; immune-related adverse events; validation; prediction
subject: 610 Medizin

description: Immune checkpoint inhibitors have revolutionized treatment of advanced melanoma, but commonly cause serious immune-mediated complications. The clinical ambition of reserving more aggressive therapies for patients least likely to experience immune-related adverse events (irAE) has driven an extensive search for predictive biomarkers. Here, we externally validate the performance of 59 previously reported markers of irAE risk in a new cohort of 110 patients receiving Nivolumab (anti-PD1) and Ipilimumab (anti-CTLA-4) therapy. Alone or combined, the discriminatory value of these routine clinical parameters and flow cytometry biomarkers was poor. Unsupervised clustering of flow cytometry data returned four T cell subsets with higher discriminatory capacity for colitis than previously reported populations, but they cannot be considered as reliable classifiers. Although mechanisms predisposing some patients to particular irAEs have been described, we are presently unable to capture adequate information from pre-therapy flow cytometry and clinical data to reliably predict risk of irAE in most cases.
Multiparametric Sonographic Imaging of Thyroid Lesions: Chances of B-Mode, Elastography and CEUS in Relation to Preoperative Histopathology
Creators: name: Brandenstein, Moritz
name: Wiesinger, Isabel
name: Künzel, Julian
name: Hornung, Matthias
name: Stroszczynski, Christian
name: Jung, Ernst-Michael
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: CONTRAST-ENHANCED ULTRASOUND; NODULES; IDENTIFICATION; GUIDELINES; BENIGN; solid thyroid lesions; B-mode; shear-wave elastography; CEUS; histopathology
subject: 610 Medizin

description: Simple Summary As the incidence of thyroid lesions in Europe is rising, more and more people affected by thyroid pathologies seek treatment in a clinic. Every suspicious thyroid nodule needs to be confirmed as benign or malignant in order to be treated correctly. Unnecessary invasive diagnostics and thyroid surgery should be avoided. The aim of this retrospective study was to improve the distinction between benign and malignant nodules by using new high-performance multiparametric ultrasound examination techniques. By analyzing 122 thyroid nodules we created a score-based system combining B-mode, shear-wave elastography and contrast-enhanced ultrasound malignancy criteria. This system allows for a quite accurate detection of thyroid carcinomas with a sensitivity of 95% and specificity of 75.49%. Shear-wave elastography and contrast-enhanced ultrasound can detect unique malignancy features, which cannot be found in B-mode. Therefore, these criteria would present a relevant addition to the B-mode TI-RADS classification. Background: The aim was to improve preoperative diagnostics of solid non-cystic thyroid lesions by using new high-performance multiparametric ultrasound examination techniques. Methods: Multiparametric ultrasound consists of B-mode, shear-wave elastography and contrast enhanced ultrasound (CEUS) including Time-Intensity-Curve (TIC) analysis. A bolus of 1-2.4 mL Sulfur Hexafluorid microbubbles was injected for CEUS. Postoperative histopathology was the diagnostic gold standard. Results: 116 patients were included in this study. 102 benign thyroid nodules were diagnosed as well as 20 carcinomas. Suspicious B-mode findings like microcalcifications, a blurry edge and no homogeneous sonomorphological structure were detected in 60, 75 and 80% of all carcinomas but only in 13.7, 36.3 and 46.1% of all benign lesions. The average shear-wave elastography measurements of malignant lesions (4.6 m/s or 69.8 kPa centrally and 4.2 m/s or 60.1 kPa marginally) exceed the values of benign nodules. Suspicious CEUS findings like a not-homogeneous wash-in and a wash-out were detected almost twice as often in carcinomas. Conclusion: Multiparametric ultrasound offers new possibilities for the preoperative distinction between benign and malignant thyroid nodules. A score based system of B-mode, shear-wave and CEUS malignancy criteria shows promising results in the detection of thyroid carcinomas. It reaches a sensitivity of 95% and specificity of 75.49%.
Additional file 2 of Adoption of a sustainable land management practice for invasive Prosopis juliflora in East Africa
Creators: name: Eschen, René
name: Kaaya, Omega Emmanuel
name: Kilawe, Charles Joseph
name: Malila, Barnabas Philip
name: Mbwambo, John Richard
name: Mwihomeke, Mickfanaka Steven
name: Nunda, Winnie
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Supplementary Material 2.