cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development, implementation, and evaluation of a computerized pediatric infection surveillance system
Creators: name: Rocha, Beatriz Helena de Souza Campos
Publisher: name: University of Utah
Year: 2012
Subjects: Software
Infant
Child

description: This project had two main objectives. The first objective was to determine if a computerized expert system could improve the detection of infections in hospitalized pediatric patients, and consequently help with the surveillance of hospital-acquired infections. The second objective was to analyze if computer-generated alerts and reminders about infections could influence clinicians (staff physicians, physicians' assistants, and nurse practitioners) practicing patterns. To accomplish these objectives, a computerized expert system (denominated COMPISS) using boolean rules was developed and validated in a retrospective study. During the retrospective study, newborn patient data for a two-year period from the LDS Hospital database were processed to validate COMPISS. During the retrospective validation COMPISS had a sensitivity of 84.5% and specificity of 92.8%. After the validation study, COMPISS was evaluated in two prospective studies. In the first prospective study, COMPISS was implemented into Primary Children's Medical Center (PCMC) Infection Control Program. COMPISS results were compared to the results produced by the manual surveillance done by an Infection Control Coordinator (ICC). COMPISS had a sensitivity of 100.0% for bloodstream infections and 57.1% for surgical wound infections. The ICC manual surveillance had a sensitivity of 42.6% for bloodstream infections and 47.6% for surgical wound infections. The first experiment demonstrated that COMPISS could help with the surveillance of the two studied infections and could also reduce the time required for the detection of these infections. In the second prospective study, the conclusions produced by COMPISS were presented directly to the attending clinicians in some units at PCMC. Clinician interventions were compared before and after the implementation of COMPISS. The results obtained in the second experiment failed to demonstrate a statistical difference between the clinicians' practice patterns before and after COMPISS implementation. The findings suggest that a larger sample size was required to demonstrate the small effect of the reminders. The clinicians and nurses' opinion about COMPISS were assessed through a paper questionnaire following of the second experiment. The questionnaire results demonstrated that the respondents appreciated COMPISS alerts and reminders and agreed that they should be continued and implemented in other units of the hospital.
Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard
Creators: name: Stephanie, Dietagoum Madjouka
name: Stéphane, Fongang Fotsing Yannick
name: Jules, Bankeu Kezetas Jean
name: Kaaniche, Fatma
name: Mawabo, Isabelle Kamga
name: Ngouela, Silvère Augustin
name: Sewald, Norbert
name: Lenta, Bruno Ndjakou
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: The phytochemical investigation of the methanol extract of the stem bark of Gilbertiodendron dewevrei led to the isolation of two new secondary metabolites, 5,7-dihydroxy-4′-methoxyisoflavan-2,4-dione (1) and 23-hydroxy-2-tricosanone (2) along with 19 known compounds (3–21). The structure of these compounds were established by interpretation of their spectral data, mainly HR-TOFESIMS, 1 D NMR (1H, 13C and DEPT) and 2 D NMR (1H–1H COSY, HSQC, HMBC, and NOESY), and by comparison with those reported in the literature. The methanol extract and some isolates were screened for their antiradical, antibacterial, and inhibitory properties against acetylcholinesterase.
HEDGING ORIGINAL SENT 4 PUBLICATION.doc
Creators: name: Nwoko, Chibuzo
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470404
subject: Corpus linguistics

description: This paper underscores the use of hedging as a linguistic resource literary artists deploy in their fictional texts to give their works a sense of reality., By the application of hedging in fiction, a once phantasmagoric world turns to a world of reality to the audience.
Additional file 1 of Machine learning for the prediction of 1-year mortality in patients with sepsis-associated acute kidney injury
Creators: name: Li, Le
name: Guan, Jingyuan
name: Peng, Xi
name: Zhou, Likun
name: Zhang, Zhuxin
name: Ding, Ligang
name: Zheng, Lihui
name: Wu, Lingmin
name: Hu, Zhicheng
name: Liu, Limin
name: Yao, Yan
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Additional file 1 of Machine learning-enabled prediction of prolonged length of stay in hospital after surgery for tuberculosis spondylitis patients with unbalanced data: a novel approach using explainable artificial intelligence (XAI)
Creators: name: Yasin, Parhat
name: Yimit, Yasen
name: Cai, Xiaoyu
name: Aimaiti, Abasi
name: Sheng, Weibin
name: Mamat, Mardan
name: Nijiati, Mayidili
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 1.
Volatile constituents of leaf, stem and flower of the traditional shrub Pogostemon plectranthoides Desf. from the Western Ghats, India
Creators: name: Joshi, Rajesh K.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: The volatile organic constituents from the leaf, stem and flower of Pogostemon plectranthoides Desf. were obtained by hydro-distillation and analysed using gas chromatography equipped with a flame ionisation detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). Sixty-two, fifty-seven and forty-four compounds were identified from leaf oil (LO), stem oil (SO) and flower oil (FO). The identification was done according to their mass spectra, and their relative retention indices were determined on a non-polar stationary phase capillary column (ZB-5), representing 96.4% (LO), 94.9% (SO) and 95.2% (FO) of the total oil constituents. The major constituents were identified as (E)-β-ocimene (42.6–6.9%), germacrene D (21.1–5.9%), trans-β-guaiene (10.6–6.8%) and β-caryophyllene (9.6–6.3%) from various parts of the plant P. plectranthoides. The oil was found (E)-β-ocimene-germacrene D-trans-β-guaiene chemotypes from the plant growing in the Western Ghats of this region.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.03.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Chemical composition of essential oils from four Piper species, differentiation using multivariate analysis and antioxidant activity
Creators: name: Araujo, Carolina Alves
name: da Camara, Claudio A. G.
name: de Moraes, Marcilio Martins
name: de Vasconcelos, Geraldo J. N.
name: Pereira, Marta R.
name: Zartman, Charles E.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry

description: Essential oils from the leaves of four species of Piper obtained through hydrodistillation were analyzed using GC-MS andmultivariate data analysis. The chemical analysis enabled the identification of qualitative and quantitative differences among the oils. β-selinene (32.44 ± 1.14%), (E)-nerolidol (44.23 ± 2.23%), β-caryophyllene (19.11 ± 0.40%) and caryophyllene oxide (16.92 ± 0.21%) were identified as the major constituents of the P. mollipilosum, P. brachypetiolatum, P. glandulosissimum and P. madeiranum oils, respectively. The differences in the chemical profiles of the oils were confirmed by principal component analysis. All four species exhibited antioxidant activity. The oil from P. brachypetiolatum achieved the best results on the DPPH test (EC50 = 64.8 µg/ml) and with the ABTS radical (EC50 = 159.7 µg/ml).
Additional file 1 of A non-linear approach to the establishment of local biological control agent production units: a case study of fall armyworm in Bangladesh
Creators: name: Kadzamira, Mariam A. T. J.
name: Chaudhary, Malvika
name: Williams, Frances
name: Dutta, Nirmal K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Annex S1. Data collected from Agricultural Research Institute (BARI) regional research stations. Annex S2. Baseline data – BARI research station – headquarters. Annex S3. a Baseline data for FPOs included in study. b Summary statistics of FPOs included in study.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.02.1968, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.02.1968, erstellt von Annie Hovaere, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung Nr. 22710.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.02.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Organoid Kidney Culture for Drug Toxicity Screening
Creators: name: Astashkina, Anna
Publisher: name: University of Utah
Year: 2014

description: Experimental models that faithfully reflect both normal physiological and pathological conditions represent an essential cornerstone of both the basic and applied sciences. However, the degrees to which these models represent actual in vivo conditions and environments greatly affect their ability to accurately produce clinically relevant responses to stimuli such as drug exposures. This dissertation introduces an in vitro kidney proximal tubule model that aims to retain tissue architecture, cell organization, cell-matrix and cell-cell interactions, and physiological cellular responses in long-term culture, and assess its ability to preserve differentially and functionally stable primary cells during exposure to drugs known to be nephrotoxic. These features are achieved by encapsulating suspended harvested viable proximal tubule fragments containing their epithelial cells in a three-dimensional hyaluronic acid (HA) hydrogel matrix. Proximal tubule fragment (i.e., "organoid") encapsulation, and not their isolated cells suspensions, in the hydrogel endows the model with the capability to retain native cellular organization, extracellular matrix, and intra- and extra-cellular interactions, while limiting non-native cell-polymer interfaces. Data collected for these cultures indicate that proximal tubule epithelial cells sustain cellular gluconeogenic potential, differential markers, and functional ligands. Moreover, these kidney cells in vitro were capable of responding to exogenous agents (i.e., drug introductions) with induction of in vivo-relevant gene and protein biomarkers as well as accurate cytokine, cytochrome, and iv metabolite expression patterns. The utility of the model for assessing potential nephrotoxic agents was further validated by comparison to the "gold standard" of current in vitro toxicology: immortalized cell monolayers grown on plastic. Results demonstrate significant improvements in cell phenotypic fidelity for 3D organoid cultures over cells supported via standard in vitro culture techniques that produce most clinically measured biomarkers. The obtained results indicate that preservation of the cellular microenvironment is key to not only sustaining functional proximal tubule cells in vitro but also in preserving their natural responses to the same nephrotoxic indicators as expressed in animal toxicity models. The proposed 3D in vitro culture model bridges the gap between overly simplistic cellular and costly in vivo assessment, and opens possibilities for direct, reliable and predictive comparisons between in vitro and clinical data.
Sonnenfleckenzeichnung Nr. 22695.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity
Creators: name: Pham, Ty Viet
name: Bach, Hieu Kim Thi
name: Ho, Duc Viet
name: Nguyen, Bao Chi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Two new compounds, designated as knecorticosanones A–B (1–2), along with three known compounds (3–5) were isolated from the fruits of Knema globularia. Their structures were elucidated by extensive spectroscopy analysis, including 1D- and 2D-NMR, UV, IR, and HRESIMS and by comparison with the reported data in the literature. Compounds 1–5 were evaluated for their cytotoxicity. Knecorticosanone B (2) and malabaricone D (5) exhibited moderate cytotoxic effect against Hep-G2, MCF-7 and SK-LU-1 cell lines with IC50 values ranging from 8.76 ± 1.02 to 18.74 ± 1.75 μM while knecorticosanone A (1), virolane (3) and 7-hydroxy-3′,4′-methylenedioxyflavan (4) exhibited weak inhibitory effect against these cell lines with IC50 values ranging from 25.85 ± 2.75 to 66.75 ± 2.08 μM.
Detection of protein and small molecule interactions with lipid membranes using second harmonic generation and ultraviolet-visible sum-frequency generation
Creators: name: Nguyen, Trang Thao
Publisher: name: University of Utah
Year: 2012
Subjects: Lipid membranes
Second harmonic generation
Ultraviolet-visible sum-frequency generation
Ligand-protein recognition
Drug-membrane associations
Ibuprofen
Azithromycin
Tetracaine
Tolnaftate

description: This work describes the use of second harmonic generation (SHG) and ultraviolet-visible sum-frequency generation (UV-Vis SFG) to directly detect ligand-protein recognitions and drug-membrane associations. First, SHG spectroscopy was employed to detect protein-ligand binding for several model systems: avidin, streptavidin, neutrAvidinTM and anti-biotin antibody binding to biotin. The equilibrium binding affinities of these model systems were measured and compared with those values reported in literature to validate the ability of SHG to detect protein-ligand interactions without any chemical modification. Furthermore, the energetics of the protein-ligand binding and the protein nonspecific adsorption were evaluated to provide useful information about these protein-ligand pairs which are commonly used in many bioanalytical applications.  Next, UV-Vis SFG spectroscopy was developed and utilized to detect drug-lipid membrane association for four drugs: ibuprofen, azithromycin, tetracaine, and tolnaftate. Drug association was measured on planar supported lipid bilayers composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine. The drugs' equilibrium association constants were obtained and correlated with the drugs' partition coefficients in the membrane-water system. Furthermore, the drug surface excess in the lipid membrane was quantitatively determined using the combination of the UV-Vis SFG and the bulk partition coefficient. It was shown that UV-Vis SFG is a powerful and novel technique to directly measure the association of drugs to a lipid membrane without chemical modification.  Finally, SHG imaging was employed in the label-free detection of the interactions between tetracaine and a multicomponent planar supported lipid bilayer array (MLBA). The MLBAs allowed the effects of lipid phase and cholesterol content on tetracaine binding to be examined simultaneously. Additionally, tetracaine binding at different charge states and the effect of the charged lipids were investigated. The maximum surface excess of tetracaine in the lipid bilayers was also determined. This demonstrates that SHG imaging is a sensitive technique which can directly image and quantitatively measure the association of tetracaine in a high-throughput manner.  This work has demonstrated that SHG and UV-Vis SFG are valuable alternatives in detection of biomolecular interactions at a lipid bilayer surface. The use of SHG or UV-Vis SFG imaging in combination with the MLBAs offer potential applications in high-throughput screenings of proteins and small molecules.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.02.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Existence of solutions to nonlinear elliptic equations
Creators: name: Nguyen, Loc Hoang
Publisher: name: University of Utah
Year: 2012
Subjects: Boundary value problems
Solutions
Nonlinear elliptic equations

description: This dissertation is concerned with the existence of solutions to fully nonlinear elliptic equations of the form  Au = Fu,  where A is a differential operator acting on a subspace of the Sobolev space W1,p loc (?), p > 1, ? is a bounded domain in RN and F is an operator depending on lower order terms which also satisfies certain growth conditions. In our study, we use variational methods,  fixed point theorems and, especially, sub-supersolution theorems. Our sub-supersolution theorems obtained are motivated by and are more general than those of Vy Le and Schmitt. With our approach, the operator F is allowed to be singular, to contain convection terms and to involve nonlocal terms.
Additional file 1 of Impact of machined versus structured implant shoulder designs on crestal bone level changes: a randomized, controlled, multicenter study
Creators: name: Rothamel, Daniel
name: Heinz, Maria
name: Ferrari, Daniel
name: Eissing, Alfons
name: Holtmann, Henrik
name: Schorn, Lara
name: Fienitz, Tim
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology

description: Additional file 1. Implant positions, implant diameters and implant lengths of included patients.
Dendropaemon (Rutilopaemon) refulgens Waterhouse 1891
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dendropaemon
Dendropaemon refulgens

description: Dendropaemon (Rutilopaemon) refulgens Waterhouse, 1891
Dendropemon refulgens Waterhouse 1891b: 56 (French Guiana)
Distribution. French Guiana: Waterhouse 1891b: 56 (as Dendropemon refulgens); Olsoufieff 1924: 125; Blut 1939: 271; Brûlé et al. 2014: 183; Génier and Arnaud 2016: 66; Boilly et al. 2016: 94. “Guianas”: Gillet 1911b: 88 (as Dendropemon refulgens); Blackwelder 1944: 211 (as Dendropemon refulgens). Brazil: Olsoufieff 1924: 125; Vaz-de-Mello 2000: 192 (as Dendropaenon [sic] (Coprophanaeoides) refulgens refulgens). Venezuela (EO): Martínez and Clavijo 1990: 154 (EO). Other: Medina et al. 2001: 140 (Colombia).
Note. According to Génier and Arnaud (2016: 52), the specimen of Dendropaemon refulgens mentioned for Venezuela in Martínez and Clavijo (1990: 154) was actually a new species that they described as D. (Glaphyropaemon) inemarginatus. Concerning the true D. refulgens, Génier and Arnaud (2016) only studied the holotype and thus restrict its known range to the type locality French Guiana. They do not discuss the records of this species for Brazil in Olsoufieff (1924: 125) and Vaz-de-Mello (2000: 192), nor the record for Colombia in Medina et al. (2001: 140). We regard the occurrence of this species in Brazil and Colombia as in need of confirmation. Pending future results, it seems unwise to fully exclude the option that the species might occur in Venezuela, as this country is situated between French Guiana and Colombia.
Subgenus STREBLOPAEMON Génier and Arnaud, 2016
Dendropaemon (Streblopaemon) Génier and Arnaud 2016: 68
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 100, DOI: 10.5281/zenodo.3678492
Profiling of the lipophilic components of seed oil obtained from two medicinal plants Corchorus capsularis L. and Hibiscus sabdariffa L.
Creators: name: Sahu, Pravin Kumar
name: Sipeniece, Elise
name: Radziejewska-Kubzdela, Elżbieta
name: Grygier, Anna
name: Patel, Khageshwar Singh
name: Rudzińska, Magdalena
name: Radzimirska-Graczyk, Monika
name: Górnaś, Paweł
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: The minor lipophilic composition of seed oils obtained from two medicinal plants (C. capsularis and H. sabdariffa L.), tocopherol, tocotrienols, sterols, carotenoids and squalene, was studied. The oil yield from the seeds of H. sabdariffa and C. capsularis was 19.1 and 12.7%, respectively. The main three fatty acids of the oils from both species were – linoleic, oleic, and palmitic acid (over 95% of all). γ-Tocopherol consisted of over 65% of total tocopherol content of four detected homologues, in both species. Nine and ten sterols were detected in H. sabdariffa and C. capsularis seed oil, respectively. β-Sitosterol was the main sterol (over 50% of all). Lutein was the main carotenoid detected in both species. The total amount of tocopherols, carotenoids and sterols in C. capsularis vs. H. sabdariffa seed oil were 117.2 vs. 159.2, 0.27 vs. 0.74, and 247.1 vs. 968.0 mg/100 g oil, respectively.
Cellular and Molecular Mechanisms of FGF8 Signaling in Cardiac Outflow Tract Development and Remodeling
Creators: name: Park, Eon Joo
Publisher: name: University of Utah
Year: 2012
Subjects: Heart
Fibroblast Growth Factors

description: The heart is the central organ of the cardiovascular system. It pumps the oxygenrich  blood to the body and the oxygen-poor blood to the lung. The correct septation of  cardiac chambers and connection of blood vessels are required for normal circulation.  Abnormal development during embryogenesis can result in congenital heart defects,  which are the most common birth defect. Thus, understanding how the heart develops  normally is important. The mechanisms and the signaling involved in heart  morphogenesis have been studied extensively, but much remains unknown. This chapter  will provide an overview of mouse cardiac development, known regulatory mechanisms  of outflow tract remodeling and known roles of fibroblast growth factor signaling in  cardiac development. I will also introduce the four projects in my thesis.
Additional file 1 of Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors
Creators: name: Porter, Lucy L.
name: Simons, Koen S.
name: Corsten, Stijn
name: Westerhof, Brigitte
name: Rettig, Thijs C. D.
name: Ewalds, Esther
name: Janssen, Inge
name: Jacobs, Crétien
name: van Santen, Susanne
name: Slooter, Arjen J. C.
name: van der Woude, Margaretha C. E.
name: van der Hoeven, Johannes G.
name: Zegers, Marieke
name: van den Boogaard, Mark
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file1 (DOCX 8703 kb)
A regioselective synthesis of 7-methyl juglone and its derivatives
Creators: name: Cui, Jiahua
name: Li, Shaoshun
name: Jia, Jinping
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: 7-Methyl juglone as a naturally occurring naphthoquinone showed striking antibacterial, antifungal, antivirus and anticancer activity. Its derivatives had also been characterized as key intermediates in the preparation of natural naphthoquinones and anthraquinones. Herein, we reported a regioselective synthesis of 7-methyl juglone via the construction of fused polycyclic systems. The key steps of the strategy involved Stobbe condensation of 2,5-dimethoxy benzaldehyde with diethyl succinate, intramolecular cyclization, reduction, acid-facilitated debenzylation and further cerium(IV) ammonium nitrate-mediated oxidation. Compared with the reported methods employing Birch conditions in liquid ammonia or Friedel-Crafts cycloacylation with melting heat of aluminum salts, the reaction conditions in the new synthetic route were milder and suitable for large scale preparations. In addition, all of the starting materials in the synthesis were readily available. It has great implications for the design and synthesis of structurally asymmetric naphthoquinones derivatives.
An analysis of PHA-4 and its cofactors during pharynx development in C; elegans
Creators: name: Updike, Dustin L.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Genetic Regulation

description: As development progresses, cells become specialized and adopt a regional, cellular, tissue, or organ specific fate. This fate is directed by a specialized group of transcription factors called selector genes. Selector genes act at the top of a hierarchy and orchestrate expression of multiple target genes, thereby enacting developmental differentiation programs. One of these selector genes is the winged helix transcription factor FoxA. FoxA is essential for digestive tract development in all animals that it has been studied. For example, in the nematode Caenorhabditis elegans the FoxA homolog, pha-4, specifies pharyngeal, or foregut, cells. When it is disrupted, cells that would have become the pharynx develop as ectoderm. Despite the importance of FoxA proteins during foregut development, little is known about FoxA regulators and cofactors. To identify cofactors of FoxA, we performed a mutagenesis in  C. elegans to screen for loci that interact genetically with pha-4. From this screen, 2 recessive and 11 dominant regulators of PHA-4 expression or activity were identified that suppress lethality associated with a partial loss of pha-4 function. Single nucleotide polymorphisms were used to map the 13 pha-4 suppressors, which showed that at least 9 genes were obtained from the screen. One of the dominant suppressors was identified as an allele of pha-4 itself, which demonstrated the effectiveness of the screen. Next, we looked in depth at a second pha-4 suppressor that was identified as a loss-of-function in the predicted DNA helicase ruvb-1.  ruvb-1 is a known component of the Esa1/TIP60 and Swr1/p400 chromatin modifying and remodeling complex in eukaryotes. We investigated the role of chromatin remodeling during pharyngeal development and discovered that homologous components of the Esa1/TIP60 and Swr1/p400 remodeling complex act synergistically with pha-4 by associating the H2A histone variant, HTZ-1/H2AZ, to pharyngeal promoters. These findings are the first to demonstrate an in vivo requirement for chromatin remodeling during foregut development. Finally, we investigated additional phenotypes associated with the ruvb-1 mutant, which resemble mutations in the TOR kinase nutrient sensing pathway in C. elegans. The roles of ruvb-1 and pha-4 in nutrient sensing and metabolism during postembryonic development were examined.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 22706.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.02.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Palladium-catalyzed functionalization of alkenes to provide biologically relevant scaffolds
Creators: name: Pathak, Tejaskumar Pankajbhai
Publisher: name: University of Utah
Year: 2012
Subjects: Alkene functionalization
Biological study
Difunctionalization
Enantioselective
Indole
Palladium
Biologically relevant scaffolds

description: ortho-Quinone methides (o-QMs) are highly reactive intermediates with various applications in chemical and biological sciences. In the last decade, chemists have  utilized o-QM reactivity to develop numerous synthetic transformations that provide access to biologically relevant scaffolds, such as chromanes. However, enantioselective functionalization of o-QM is still a challenge. Presented herein are functionalization  reactions of o-QMs with a chiral Pd-catalyst to provide biologically relevant chromane and bis-arylmethane scaffolds in excellent enantioselectivity. These studies are followed by development of hydrofunctionalization of vinyl phenols and vinyl indoles to provide the corresponding bis-arylmethanes.  In the first study, a unique approach to alkene difunctionalization was taken based on a mechanistic hypothesis of a quinone methide intermediate in a related reaction. Substrates containing an alkene adjacent to an ortho-phenol and a tethered nucleophile were prepared, allowing for the regioselective addition of two distinct nucleophiles. The reaction was applied to the dialkoxylation of alkenes, resulting in the enantioselective  formation of heterocyclic compounds bearing two adjacent chiral centers.  In the second study, a Pd-catalyzed enantioselective reaction of indoles with o-QMs was developed, using a similar strategy as above, to provide bis-arylmethanes.  Since many biologically active compounds contain bis-arylmethane functionality, several of the newly synthesized compounds were screened against breast cancer cell lines. Two of newly synthesized bis-arylmethanes, 69 and 72, demonstrated micromolar anti-cancer activity against breast cancer cell lines with different phenotypes.  Inspired by promising biological activity of bis-arylmethanes, a unique hydrofunctionalization reaction of vinyl phenol with heteroaromatics was developed to provide analogous structures. The key development in this process is use of alkyl  chloride as a sacrificial hydride source to provide the requisite Pd-hydride.  Finally, acid-catalyzed hydrofunctionalization of vinyl indoles with heteroaromatics was developed. This process provides unsymmetrical bisindolylmethanes  in high yields. The biological studies of newly synthesized compounds demonstrated anti-cancer activity against breast cancer cell lines. One of the newly synthesized compound, 149, demonstrated excellent deferential activity between wildtype breast cell lines and cancerous cell lines.
MPEC 2024-J66 : 2024 JH1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 JH1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.02.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Heterophynone and methyl ester of Colic acid, two new compounds with antimicrobial activity from Cola heterophylla (Sterculiaceae)
Creators: name: Noah, Martin Mbané
name: Fotsing, Maurice Tagatsing
name: de Théodore Atchadé, Alex
name: Mkounga, Pierre
name: Boyom, Fabrice Fekam
name: Talla, Emmanuel
name: Henoumont, Celine
name: Sophie, Laurent
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The ethyl acetate fraction, the stem bark and the residual methanolic extracts from the leaves of Cola heterophylla (Sterculiaceae) led to the isolation of two new compounds: Heterophynone (1) and methyl ester of Colic acid (6), along with four known triterpenes: betulinic acid (2), oleanolic acid (3), ursolic acid (4) and chletric acid (5). Structures of compounds were established by different spectroscopic methods that included 1D and 2D NMR experiment. The antimicrobial activity of isolated compounds was evaluated against two yeasts, Candida Albicans NR 29456 and Candida Krusei 1415; and five Gram-positive bacterial, Salmonella enteric Serovar Muenchem, Salmonella enteric Serovar Thyphimurium, Staphylococcus aureus NR 46003, Staphylococcus aureus NR46374 and Pseudomonas aeruginosa HM 601). Among tested compounds, Heterophynone was found to be the most active with significant antimicrobial activity against Salmonella enteric Serovar Thyphimurium (MIC = 7.82 μg/mL and MBC = 62.5 μg/mL) and good activity against Candida Albicans NR 29456 (MIC = 62.5 μg/mL).
Optic Tract Formation: Retinal Axons' Interaction with Their Pioneers and Peers, and a Strategy to Analyze Variants of Guidance Receptor Messengers RNAs
Creators: name: Law, Mei Yee
Publisher: name: University of Utah
Year: 2014

description: How neural connections are established spontaneously to generate a functioning nervous system remains an important question in the field of developmental biology. Axons and dendrites extended from various cell types have to form at the right place and right time to make appropriate connections. An enormous number of molecules is present in the developing embryos. Experimental analyses are further complicated by virtue of these molecules' ability to interact and affect the function of other molecules. I first set out to test the role of a cell biological mechanism-axon fasciculation-in guiding axon pathfinding within the zebrafish visual system. I then focused on the role of a transmembrane receptor, Robo2, and its splice variants in axon guidance. In Chapter 1, I present some important questions in axon guidance and alternative splicing, along with reviews of factors involved in retinal axon guidance. I also introduce the roles of alternative splicing in increasing protein diversity and thus contributing to various responses in pathfinding along the axon trajectory. Chapter 2 is a collaborative peer-reviewed paper published in Development showing that early-born retinal ganglion cells guide later-born cells within and outside of the eye. In Chapter 3, I described my observation of robo2 alternative splice forms in developing zebrafish embryos and my experiments using morpholinos to test the domains iv functionally. Finally, Chapter 4 discusses the findings and future directions of the studies.
Sonnenfleckenzeichnung Nr. 22693.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.02.1968, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Applicability of colloid filtration theory in size-distributed, reduced porosity, granular media in the absence of energy barriers
Creators: name: Pazmin?o, Eddy Fernando
Publisher: name: University of Utah
Year: 2012
Subjects: Colloid transport
Favorable conditions
Filtration theory
Low porosity
Size-distributed media

description: The vast majority of colloid transport experiments have been conducted in granular porous media with narrow size distribution, which allows a single collector size and narrow values of porosity to be used in colloid filtration theory to predict deposition rates under favorable conditions (absence of energy barriers). In this work, deposition of colloids (ranging from 0.21 mm to 9.1 mm)  in packed columns was examined with three different borosilicate glass bead porous media: uniform, monomodal nonuniform and bimodal nonuniform. The corresponding porosities to these media were 0.38, 0.34 and 0.28. The effect of reduced porosity on the flow field was studied using high resolution computerized X-ray micro tomography (HRXMT), Lattice-Boltzmann (LBM) flow simulation methods, and direct observations in packed flow cells. This allowed discerning the influence of preferential flow paths on fluid velocities, and it demonstrated that straining in pore throats too small to pass was not a significant contributor to colloid retention even up to particle to grain size ratios of 0.05. Mechanistic simulations successfully predicted the experimentally-observed sensitivity to porosity and absolute values of the deposition rate coefficients when a  number-based mean grain size was used to represent the size-distributed porous media.
The impact of indoor and outdoor exercise programs on anthropometric, body composition, metabolic status, cardiovascular response, and neuromuscular capacity in individuals with Intellectual Developmental Disabilities
Creators: name: Jacinto, Miguel
name: Matos, Rui
name: Monteiro, Diogo
name: Antunes, Raul
name: Caseiro, André
name: Gomes, Beatriz
name: Campos, Maria João
name: Ferreira, José Pedro
Publisher: name: Motricidade
Year: 2024

description: The increase in overweight and obesity among individuals with Intellectual and Developmental Disabilities (IDD) also increases the deterioration of functionality and the risk of developing chronic diseases. Physical exercise has been identified as an effective strategy for reducing overweight and obesity and promoting health. The aim of this study was to investigate the effects of an indoor and outdoor exercise programme on individuals with IDD. Were split by convenience into three groups twenty-one adults with IDD (43.04 ± 11.18 years): i) an indoor training group (IG; N=7; 24-week machine-based gym intervention), ii) an outdoor training group (OG; N=7; 24-week outdoor intervention with low-content materials), and iii) a control group (CG; N=7). Various variables were assessed, including indicators of health and neuromuscular capacity. The Shapiro-Wilk (n<50) and Levene tests were used to verify data normality and homoscedasticity. A Kruskal-Wallis test was performed to understand if there were differences between the groups. The Wilcoxon signed-rank test and the Friedman test were used to understand if there were differences between moments. The effect size was calculated, and the significance level was defined at 0.05. There was a difference in fat mass in OG (pré ≠ intermediate; Bonferroni corrected: t=2.405; p=0.048; W=0.08 and pré ≠ post moments; Bonferroni corrected: t=2.405; p=0.048; W=0.08). Indoor intervention programs seem to be more effective than outdoor intervention programs for reducing heart rate rest (t=-2.912; p=0.011; W=-0.104) when compared with CG. A low-cost outdoor exercise program intervention in contact with nature seems more effective in reducing fat mass. An indoor exercise program intervention using weight machines appears to be a suitable method for promoting neuromuscular capacity.
description: Motricidade, Vol. 20 No. S1 (2024): CIDESD International Congress 2023