cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs
Creators: name: Heuzeroth, Hanno
name: Wawra, Matthias
name: Fidzinski, Pawel
name: Dag, Ramazan
name: Holtkamp, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: 4-aminopyridine
subject: in vitro
subject: lacosamide
subject: levetiracetam
subject: zonisamide
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary. So far, little attention has been paid to in vitro models, which are also able to detect antiepileptic efficacy and in principle could likewise serve for exploratory preclinical screening. One of the established in vitro models of acute seizures is the 4-aminopyridine (4-AP) model. Previous studies have shown that the 4-AP model is capable to recapitulate the antiepileptic efficacy of standard antiepileptic drugs (AEDs) such as valproate or carbamazepine. Here, we employed a dual methodological approach using electrophysiology and optical imaging to systematically test the antiepileptic efficacy of three new-generation AEDs with distinct mechanisms of action (lacosamide, zonisamide, and levetiracetam). We found that frequency of 4-AP induced seizure like events (SLE) was the most sensitive parameter to detect dose-dependent antiepileptic effects in these compounds. Specifically, levetiracetam reduced SLE frequency while lacosamide and zonisamide at higher doses completely blocked SLE incidence. Analysis of the intrinsic optical signal additionally revealed a subiculum-specific reduction of the area involved in the propagation of ictal activity when lacosamide or zonisamide were administered. Taken together, our data adds some evidence that acute seizure models in vitro are in principle capable to detect antiepileptic effects across different mechanisms of action with efficacy similar to acute models in vivo. Further studies with negative controls, e.g., penicillin as a proconvulsant, and other clinically relevant AEDs are needed to determine if this acute in vitro model might be useful as exploratory screening tool. In view of the increasing sensitivity toward animal welfare, an affective in vitro model may help to reduce the number of laboratory animals deployed in burdening in vivo experiments and to preselect substances for subsequent testing in time- and cost-laborious models of chronic epilepsy.
The optically-selected 1.4-GHz quasar luminosity function below 1 mJy
Creators: name: Malefahlo, Eliab
name: Santos, Mario G.
name: Jarvis, Matt J.
name: White, Sarah V.
name: Zwart, Jonathan T. L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the radio luminosity function (RLF) of optically-selected quasars below 1~mJy, constructed by applying a Bayesian-fitting stacking technique to objects well below the nominal radio flux-density limit. We test the technique using simulated data, confirming that we can reconstruct the RLF over three orders of magnitude below the typical $5σ$ detection threshold. We apply our method to 1.4-GHz flux-densities from the Faint Images of the Radio Sky at Twenty-cm survey (FIRST), extracted at the positions of optical quasars from the Sloan Digital Sky Survey (SDSS) over seven redshift bins up to $z=2.15$ {and measure the RLF down to two orders of magnitude below the FIRST detection threshold}. In the lowest redshift bin ($0.2
description: 20 pages, 14 figures, 5 tables
MOESM3 of Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report
Creators: name: Soliman, Hany
name: Abouelhoda, Mohamed
name: Rouby, Mahmoud
name: Ahmed, Ola
name: G. Esmat
name: Hassan, Zeinab
name: Hafez, Mohammed
name: Mehaney, Dina
name: Manojkumar Selvaraju
name: Darwish, Rania
name: Osman, Yehia
name: Zekri, Abdel-Rahman
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3: Identification of 808 SNPs.
Additional file 1 of Teledentistry as a novel pathway to improve dental health in school children: a research protocol for a randomised controlled trial
Creators: name: Estai, Mohamed
name: Kanagasingam, Yogesan
name: Mehdizadeh, Maryam
name: Vignarajan, Janardhan
name: Norman, Richard
name: Huang, Boyen
name: Spallek, Heiko
name: Irving, Michelle
name: Arora, Amit
name: Kruger, Estie
name: Tennant, Marc
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*
The sigma-Meson Production in Excited Upsilon Decay Processes
Creators: name: Komada, Toshihiko
name: Ishida, Muneyuki
name: Ishida, Shin
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the pipi production amplitudes in the excited Upsilon decay processes, Upsilon (2S) to Upsilon (1S)pi^+pi^-, Upsilon (3S) to Upsilon (1S)pi^+pi^- and Upsilon (3S) to Upsilon (2S)pi^+pi^-, and the pipi and KKbar production amplitudes in the charmonium decay processes, psi (2S) to Jpsi pi^+pi^- and Jpsi to phi pi^+pi^-, phi K^+K^-, including the possible effect of light sigma production. The amplitudes are parametrized by the sum of Breit-Wigner amplitudes for the sigma and the other relevant particles and of the direct 2pi-production amplitude, following the VMW method. All the pipi (and KKbar mass spectra are reproduced well with the obtained values of sigma-parameters, m_sigma =526(+48,-37)MeV and Gamma_sigma =301(+145,-100)MeV, which is almost consistent with the values in our previous phase shift analyses.
description: proc. of "Hadron '01," Protvino, Russia, Aug, 2001. 5 pages, uses ptptex.sty
Asymptotic approximation of the eigenvalues and the eigenfunctions for the Orr-Sommerfeld equation on infinite intervals
Creators: name: Nijimbere, Victor
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Asymptotic eigenvalues and eigenfunctions for the Orr-Sommerfeld equation in two and three dimensional incompressible flows on an infinite domain and on a semi-infinite domain are obtained. Two configurations are considered, one in which a short-wave limit approximation is used, and another in which a long-wave limit approximation is used. In the short-wave limit, WKB methods are utilized to estimate the eigenvalues, and the eigenfunctions are approximated in terms Green's functions. The procedure consists of transforming the Orr-Sommerfeld equation into a system of two second order ordinary differential equations for which eigenvalues and eigenfunctions can be approximated. The approximated eigenvalues can, for instance, be used as a starting point in predicting transitions in boundary layers with computer simulations (computational fluid dynamics). In the long-wave limit approximation, solutions are expressed in terms of generalized hypergeometric functions.
description: 30 pages; 2 figures
Additional file 11 of Transcriptomic analysis of flower induction for long-day pitaya by supplementary lighting in short-day winter season
Creators: name: Xiong, Rui
name: Liu, Chengli
name: Xu, Min
name: Wei, Shuang-shuang
name: Huang, Jia-quan
name: Tang, Hua
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 11: Supplemental S11. Three main TFs involved in pitaya flowering stage.
MOESM2 of Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report
Creators: name: Soliman, Hany
name: Abouelhoda, Mohamed
name: Rouby, Mahmoud
name: Ahmed, Ola
name: G. Esmat
name: Hassan, Zeinab
name: Hafez, Mohammed
name: Mehaney, Dina
name: Manojkumar Selvaraju
name: Darwish, Rania
name: Osman, Yehia
name: Zekri, Abdel-Rahman
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2: The best alignment of our sequence with ref. seq. JN127373.1.
Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation
Creators: name: Prüss, Harald
name: Gessner, Guido
name: Heinemann, Stefan H.
name: Rüschendorf, Franz
name: Ruppert, Ann-Katrin
name: Schulz, Herbert
name: Sander, Thomas
name: Rimpau, Wilhelm
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: KCNQ1
subject: LQT syndrome
subject: familial epilepsy
subject: genetic modifier
subject: risk haplotype
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, and the sudden unexplained death in epilepsy (SUDEP) was considered to be the pathologic overlap between the two clinical conditions. For LQT-associated KCNQ1 mutations, only few investigations reported the coincidence of cardiac dysfunction and epileptic seizures. Clinical, electrophysiological and genetic characterization of a large pedigree (n = 241 family members) with LQT syndrome caused by a 12-base-pair duplication in exon 8 of the KCNQ1 gene duplicating four amino acids in the carboxyterminal KCNQ1 domain (KCNQ1dup12; p.R360_Q361dupQKQR, NM_000218.2, hg19). Electrophysiological recordings revealed no substantial KCNQ1-like currents. The mutation did not exhibit a dominant negative effect on wild-type KCNQ1 channel function. Most likely, the mutant protein was not functionally expressed and thus not incorporated into a heteromeric channel tetramer. Many LQT family members suffered from syncopes or developed sudden death, often after physical activity. Of 26 family members with LQT, seizures were present in 14 (LQTplus seizure trait). Molecular genetic analyses confirmed a causative role of the novel KCNQ1dup12 mutation for the LQT trait and revealed a strong link also with the LQTplus seizure trait. Genome-wide parametric multipoint linkage analyses identified a second strong genetic modifier locus for the LQTplus seizure trait in the chromosomal region 10p14. The linkage results suggest a two-locus inheritance model for the LQTplus seizure trait in which both the KCNQ1dup12 mutation and the 10p14 risk haplotype are necessary for the occurrence of LQT-associated seizures. The data strongly support emerging concepts that KCNQ1 mutations may increase the risk of epilepsy, but additional genetic modifiers are necessary for the clinical manifestation of epileptic seizures.
title: Escape Velocity
Creators: name: Gatlin, Mark
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2005

description: Escape Velocity is a tale of flight with roots in a young naval aviation candidate and lost dreams, but it becomes much more. In fleeing a patterned desk job in Washington, DC, and the city's congested warren-like streets I discovered much about America, her people, and, most thoroughly, about myself. Essentially, I see the most interesting of travel writers as part rogue, part adventurer, and part minstrel and I strive to keep up this triumvirate tradition by discussing not only an adventure of sights and sounds, but also one of feel for the tangible experiences I encountered on my journey of ten thousand miles seeking a new home and reason for existence. On the road I pondered concepts of fear and a lack of courage in craven servitude to corporate America, ultimately leading to understanding what I want in life and, maybe just as importantly, that which I do not want.
Extensive Entropy Bounds
Creators: name: Gour, Gilad
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is shown that, for systems in which the entropy is an extensive function of the energy and volume, the Bekenstein and the holographic entropy bounds predict new results. More explicitly, the Bekenstein entropy bound leads to the entropy of thermal radiation (the Unruh-Wald bound) and the spherical entropy bound implies the "causal entropy bound". Surprisingly, the first bound shows a close relationship between black hole physics and the Stephan-Boltzmann law (for the energy and entropy flux densities of the radiation emitted by a hot blackbody). Furthermore, we find that the number of different species of massless fields is bounded by $\sim 10^{4}$.
description: 8 pages, revtex, To appear in Phys. Rev. D
Loop Currents in Two-leg Ladder Cuprates
Creators: name: Bounoua, Dalila
name: Mangin-Thro, Lucile
name: Jeong, Jaehong
name: Saint-Martin, Romuald
name: Pinsard-Gaudart, Loreynne
name: Sidis, Yvan
name: Bourges, Philippe
Publisher: name: arXiv
Year: 2019
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: New phases with broken discrete Ising symmetries are uncovered in quantum materials with strong electronic correlations. The two-leg ladder cuprate \textbf{$Sr_{14-x}Ca_{x}Cu_{24}O_{41}$} hosts a very rich phase diagram where, upon hole doping, the system exhibits a spin liquid state ending to an intriguing ordered magnetic state at larger $Ca$ content. Using polarized neutron diffraction, we report here the existence of short range magnetism in this material for two $Ca$ contents, whose origin cannot be ascribed to Cu spins. This magnetism develops exclusively within the two-leg ladders with a diffraction pattern at forbidden Bragg scattering which is the hallmark of loop current-like magnetism breaking both time-reversal and parity symmetries. Our discovery shows local discrete symmetry breaking in a one dimensional spin liquid system as theoretically predicted. It further suggests that a loop current-like phase could trigger the long range magnetic order reported at larger doping in two-leg ladder cuprates.
description: 6 figures, Supplementary information included
Conus malacanus Hwass
Creators: name: Franklin, J. Benjamin
name: Subramanian, K. A.
name: Fernando, S. Antony
name: Krishnan, K. S.
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Conus
Conus malacanus

description: 37. Conus malacanus Hwass in Bruguière, 1792 (Figure 38)
 Conus malacanus Hwass in Bruguière, 1792: 645, no. 43 (representation of holotype, Cuvier 1798: pl. 325, fig. 9 (53 x 31 mm) (Röckel et al. 1995); "Pres du dètroit de Malacca ").
 Conus canaliculatus Dillwyn, 1817: pl. 325, fig. 9 (lectotype same as holotype of C. malacanus (Walls 1979); "the coasts of Ceylon, and the Nicobar Islands. Chemnitz. Straits of Malacca. Bruguière").
 Conus subcarinatus Sowerby II, 1865: 518, pl. 32, figs. 12, 13 (two syntypes, BMNH (45 x 25; 40 x 23 mm); locality unknown).
 Conus cuneatus Sowerby III, 1873: 146, pl. 15, fig. 5 (holotype, ZMA (33 x 20 mm) (Röckel et al. 1995); " Nicobar Islands ").
 Material examined: MBMCS 137, 81 specimens, SL 42–68 mm; SW 22–36 mm.
 Description. Shell medium sized to moderately large, solid to heavy. Body whorl conical to broadly conical; outline variably convex at adapical third, straight below. Shoulder broad and carinate. Spire of low to moderate height; outline concave to straight; early whorls forming a small projecting cone. Body whorl smooth except for a few weak spiral ridges above base.
Ground colour white, body whorl usually with two variably broad continuous or interrupted brown spiral bands, leaving white zones below shoulder at centre and at base. Several widely spaced narrow axial stripes may be continuous from shoulder to base, or interrupted at mid-body. Spire and shoulder whitish, sparsely or heavily marked with brownish blotches and curved streaks, early whorls pale brown. Aperture moderately wide, uniform in width; outer lip thin, straight. Aperture white or sometimes cream. Periostracum yellow, thin, smooth and translucent.
 Distribution. Gravely (1942) reported C. malacanus (as ‘ C. voluminalis Hinds’ ) from Madras. Kohn (1978) collected a live specimen from PortoNovo. He also reported museum specimens collected off Ennore (at Madras), Karaikal (at IRSN) and Tranquebar (at ZMUC).
The specimens described herein were collected from the Northern and Palk Bay regions (Table 6) by trawling in 8–50 m, mainly on sand and sandy-mud bottoms.
 Remarks. Kohn (1978) stated that the distribution of C. malacanus is restricted to the east coast. In this survey we observed this species is limited to the Northern and Palk Bay regions. Its absence in the Gulf of Mannar and further south probably suggests that it is not a coral-associated species. It often occurs in the same habitat as like C. monile, C. bayani, C. amadis and C. betulinus.
description: Published as part of Franklin, J. Benjamin, Subramanian, K. A., Fernando, S. Antony & Krishnan, K. S., 2009, 2250, pp. 1-63 in Zootaxa 2250 on page 38
Photons uncertainty solves Einstein-Podolsky-Rosen paradox
Creators: name: Tommasini, Daniele
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Einstein, Podolsky and Rosen (EPR) pointed out that the quantum-mechanical description of "physical reality" implied an unphysical, instantaneous action between distant measurements. To avoid such an action at a distance, EPR concluded that Quantum Mechanics had to be incomplete. However, its extensions involving additional "hidden variables", allowing for the recovery of determinism and locality, have been disproved experimentally (Bell's theorem). Here, I present an opposite solution of the paradox based on the greater indeterminism of the modern Quantum Field Theory (QFT) description of Particle Physics, that prevents the preparation of any state having a definite number of particles. The resulting uncertainty in photons radiation has interesting consequences in Quantum Information Theory (e.g. cryptography and teleportation). Moreover, since it allows for less elements of EPR physical reality than the old non-relativistic Quantum Mechanics, QFT satisfies the EPR condition of completeness without the need of hidden variables. The residual physical reality does never violate locality, thus the unique objective proof of "quantum nonlocality" is removed in an interpretation-independent way. On the other hand, the supposed nonlocality of the EPR correlations turns out to be a problem of the interpretation of the theory. If we do not rely on hidden variables or new physics beyond QFT, the unique viable interpretation is a minimal statistical one, that preserves locality and Lorentz symmetry.
description: Published version, with updated reference
Constraints on Quasi-dilaton Massive Gravity
Creators: name: Martinovic, Katarina
name: Sakellariadou, Mairi
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The last decade has seen great advancements in the field of modified gravity, motivated by the dark energy problem, or by the search for a fundamental quantum gravity theory. With a phenomenologically-driven approach, we consider dRGT theory and its extension, quasi-dilaton massive gravity (QDMG). When looking for ways to constrain the theory, a promising direction appeared to be astrophysical tests. The scalar gravitational degree of freedom and quasi-dilaton degree of freedom alter the evolution of Bardeen potentials, which in turn affects the galaxy rotation curves. We find an upper bound on graviton mass in QDMG to be $m \leq 10^{-31} {\rm eV}$. This result agrees with bounds from LIGO and numerous Solar System tests. However, the extremely small mass of the graviton remains a detection out of reach, with LISA's sensitivity exploring the parameter space up to $m \leq 10^{-25} {\rm eV}$.
description: 8 pages
Spin Clustering of Accreting X-ray Neutron Stars as Possible Evidence of Quark Matter
Creators: name: Glendenning, Norman K.
name: Weber, F.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A neutron star in binary orbit with a low-mass non-degenerate companion becomes a source of x-rays with millisecond variability when mass accretion spins it up. Centrifugally driven changes in density profile may initiate a phase transition in a growing region of the core parallel to what may take place in an isolated millisecond pulsar, but in reverse. Such a star will spend a longer time in the spin frequency range over which the transition occurs than elsewhere because the change of phase, paced by the spinup rate, is accompanied by a growth in the moment of inertia. The population of accreters will exhibit a clustering in the critical frequency range. A phase change triggered by changing spin and the accompanying adjustment of moment of inertia has its analogue in rotating nuclei.
description: 5 pages (AIPproc latex) 6 figures. To be presented at the International Conference on Nuclear Physics, 30 July - 3 August 2001, Berkeley, California
Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
Creators: name: Blois, Sandra M.
name: Dveksler, Gabriela
name: Vasta, Gerardo R.
name: Freitag, Nancy
name: Blanchard, Véronique
name: Barrientos, Gabriela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: galectins
subject: pregnancy
subject: placentation
subject: glycans
subject: preeclampsia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Galectins are a phylogenetically conserved family of soluble beta-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
Renina Hedges, Adalsteinsson, & Branch, New Subtribe
Creators: name: Adalsteinsson, Solny A.
name: Branch, William R.
name: Trape, Sébastien
name: Vitt, Laurie J.
name: Hedges, S. Blair
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Leptotyphlopidae

description: Subtribe Renina Hedges, Adalsteinsson, & Branch, New Subtribe   Type genus. Rena Baird and Girard, 1853: 142. Type species: Rena humilus Baird and Girard, 1853, by subsequent designation by Stejneger, 1892 [dated 1891]: 501.
 Diagnosis. Renina is distinguished from Epictina by having small supraoculars (versus absent or normalsized in Epictina), lacking a striped pattern, and having a uniform brown (usually dark brown) dorsum, sometimes purplish but not with reds or yellows (Table 1). Renina is distinguished from Tetracheilostomina by having 2–3 (Rena) or 3 (Tricheilostoma) supralabials versus usually 4 in Tetracheilostomina (one species has 3–4 supralabials). The support for this group was 100% BP and 100% PP for the four-gene tree (Fig. 3); only one species was included in the nine-gene tree (Fig. 4).
 Content. Two genera and 20 species (Table 1).
 Distribution. Renina is distributed in the New World from North America (California, Utah, and Kansas) south through Middle and South America (exclusive of the high Andes) to Uruguay and Argentina on the Atlantic side.
 Remarks. Renina includes the former macrolepis Group (now Tricheilostoma) and dimidiatus Group (now Rena) of " Leptotyphlops " (Orejas-Miranda 1967; Peters 1970). These two genera are broadly similar in scalation and coloration, supporting the molecular phylogenetic results.
description: Published as part of Adalsteinsson, Solny A., Branch, William R., Trape, Sébastien, Vitt, Laurie J. & Hedges, S. Blair, 2009, Molecular phylogeny, classification, and biogeography of snakes of the Family Leptotyphlopidae (Reptilia, Squamata), pp. 1-50 in Zootaxa 2244 on page 19
Confirmation of sigma(450--600)-Meson in Upsilon' to Upsilon pipi and Other pipi-Production Processes
Creators: name: Ishida, Muneyuki
name: Ishida, Shin
name: Komada, Toshihiko
name: Matsumoto, Shin-Ichirou
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Applying the effective amplitude, which is evidently consistent with general constraints from chiral symmetry, the pipi spectra in the relevant processes are analyzed, leading to a strong evidence for existence of the light sigma meson. It is also pointed out that the pipi scattering process, which had been one of the main sources for PDG table for these many years, is, in principle, exceptionally difficult to investigate the property of sigma-meson.
description: proc. of "Hadron '01," Protvino, Russia, Aug, 2001. 5 pages, uses ptptex.sty
Photoproduction of pentaquarks states at the LHC
Creators: name: Goncalves, V. P.
name: Jaime, M. M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this paper we investigate the production of pentaquark states in the photon -- proton interactions present in hadronic collisions at the RHIC and LHC. We consider two phenomenological models for the $J/Ψ$ photoproduction that consider the presence of the $P_c(4312)$, $P_c(4440)$ and $P_c(4457)$ resonances in the $s$ -- channel of the $γp \rightarrow J/Ψp$ reaction. The rapidity distribution is estimated for $pA$ collisions at the RHIC and LHC. Predictions for $pPb$, $Pb \, Ar$ and $Pb \,He$ fixed -- target collisions at the LHC are also presented. We demonstrate that the experimental analysis of the $J/Ψ$ photoproduction in fixed -- target collisions can provide complementary and independent checks on these states, and help to understand their underlying nature.
description: 6 pages, 4 figures. Improved version published in Physics Letters B
Investigation of Genetic Effects of Nucleotide Variants Within the Goat PRNT Gene on Growth Performance
Creators: name: Bi, Yi
name: Luo, Bihao
name: Zhang, Shaoli
name: Li, Jie
name: Yang, Yuta
name: Lan, Xianyong
name: Pan, Chuanying
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Our previous study has firstly pointed that three nucleotide variants (g.−11C > T, g.117A > G, and g.149C > T) of the goat PRNT gene can significantly influence litter size. Given litter size is positively correlated with growth performance, we consider whether the PRNT gene also acts on the growth performance in goats. In this work, a correlation analysis among different litter size types and growth traits of Shaanbei white cashmere (SBWC) goats was performed, and results showed that a positive correlation did exist in our detected population (P < 0.01). Then, the association among different genotypes of three variations and goat growth performance was measured. Our results pointed to g.117A > G being significantly associated with the cannon circumference (P = 4.60E-05) while no significant effect was found between another two SNPs and growth traits after the Bonferroni’s correction (P*n < 0.05). Together, this is the first report about the influence of the PRNT gene on the growth of goat and g.117A > G can be regarded as a possible DNA marker applying for MAS breeding.
Body weight changes and incidence of cachexia after stroke
Creators: name: Scherbakov, Nadia
name: Pietrock, Charlotte
name: Sandek, Anja
name: Ebner, Nicole
name: Valentova, Miroslava
name: Springer, Jochen
name: Schefold, Joerg C.
name: Haehling, Stephan Von
name: Anker, Stefan D.
name: Norman, Kristina
name: Haeusler, Karl George
name: Doehner, Wolfram
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: stroke
subject: DXA
subject: Cachexia
subject: Body weight
subject: Body composition
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Body weight loss is a frequent complication after stroke, and its adverse effect on clinical outcome has been shown in several clinical trials. The purpose of this prospective longitudinal single-centre observational study was to investigate dynamical changes of body composition and body weight after ischemic stroke and an association with functional outcome. Methods: Sixty-seven consecutive patients (age 69 ± 11 years, body mass index 27.0 ± 4.1 kg/m2, 42% female patient, mean ± SD) with acute ischemic stroke with mild to moderate neurological deficit (National Institute of Health Stroke Scale median 4, ranged 0–12) were analysed in the acute phase (4 ± 2 days) and at 12 months (389 ± 26 days) follow-up. Body composition was examined by dual energy X-ray absorptiometry. Cachexia was defined according to the consensus definition by body weight loss ≥5% within 1 year and additional clinical signs. Lean tissue wasting was considered if a ratio of upper and lower limbs lean mass sum to squared height (kg/m2) was ≤5.45 kg/m2 for female patient and ≤7.25 kg/m2 for male patient. Results: According to the body weight changes after 12 months, 42 (63%) patients had weight gain or stable weight, 11 (16%) patients had moderate weight loss, and 14 (21%) patients became cachectic. A relative decline of 19% of fat tissue and 6.5% of lean tissue was observed in cachectic patients, while no changes of lean tissue were observed in non-cachectic patients after 12 months. The modified Rankin Scale was 48% higher (2.1 ± 1.6, P < 0.05), Barthel Index was 22% lower (71 ± 39, P < 0.01), and handgrip strength was 34% lower (21.9 ± 13.0, P < 0.05) in cachectic compared to non-cachectic patients after 12 months. The low physical performance if defined by Barthel Index <60 points was linked to the lean tissue wasting (OR 44.8, P < 0.01), presence of cachexia (OR 20.8, P < 0.01), and low body mass index <25 kg/m2 (OR 11.5, P < 0.05). After adjustment for cofounders, lean tissue wasting remained independently associated with the low physical performance at 12 months follow-up (OR 137.9, P < 0.05). Conclusions: In this cohort study, every fifth patient with ischemic stroke fulfilled the criteria of cachexia within 12 months after index event. The incidence of cachexia was 21%. Cachectic patients showed the lowest functional and physical capacity.
The $ρNN$ coupling with direct coupling and loops
Creators: name: Jido, D.
name: Oset, E.
name: Palomar, J. E.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Starting from a gauge formalism of $ρ$ mesons, pions and baryons we evaluate the $ρ$ coupling to the nucleon, including the direct coupling provided by the Lagrangians, plus contributions from loops with the virtual pion cloud. We find a contribution to the magnetic $ρ$ coupling to the nucleon from pionic loops of the same size as the direct coupling, which is, however, still small compared to the empirical values. This finding goes in line with chiral formulations of the strong interaction of mesons at low energies where, unlike the scalar mesons which are mostly built of a pion (kaon) cloud, the $ρ$ meson stands as a genuine QCD state with intrinsic properties not tied to those of the pion cloud.
description: 21 pages, 13 figures
Biomarkers in Inflammatory Myopathies – An Expanded Definition
Creators: name: Benveniste, Olivier
name: Goebel, Hans-Hilmar
name: Stenzel, Werner
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: idiopathic inflammatory myopathies (IIM)
subject: myositis-specific-autoantibodies
subject: dermatomyositis (DM)
subject: immune-mediated necrotizing myopathy (IMNM)
subject: inclusion body myositis (IBM)
subject: myositis
subject: biomarker
subject: morphology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Biomarkers as parameters of pathophysiological conditions can be of outmost relevance for inflammatory myopathies. They are particularly warranted to inform about diagnostic, prognostic, and therapeutic questions. As biomarkers become more and more relevant in daily routine, this review focusses on relevant aspects particularly addressing myopathological features. However, the level of evidence to use them in daily routine at presence is low, still since none of them has been validated in large cohorts of patients and rarely in independent biopsy series. Hence, they should be read as mere expert opinions. The evaluation of biomarkers as well as key biological parameters is an ongoing process, and we start learning about relevance of them, as we must recognize that pathophysiology of myositis is biologically incompletely understood. As such this approach should be considered an essay toward expansion of the definition “biomarker” to myositis, an emerging field of interest in biomedical research.
RegulationSpotter: annotation and interpretation of extratranscriptic DNA variants
Creators: name: Schwarz, Jana Marie
name: Hombach, Daniela
name: Köhler, Sebastian
name: Cooper, David N.
name: Schuelke, Markus
name: Seelow, Dominik
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: DNA variants
subject: Whole Genome Sequencing (WGS)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: RegulationSpotter is a web-based tool for the userfriendly annotation and interpretation of DNA variants located outside of protein-coding transcripts (extratranscriptic variants). It is designed for clinicians and researchers who wish to assess the potential impact of the considerable number of noncoding variants found in Whole Genome Sequencing runs. It annotates individual variants with underlying regulatory features in an intuitive way by assessing over 100 genome-wide annotations. Additionally, it calculates a score, which reflects the regulatory potential of the variant region. Its dichotomous classifications, ‘functional’ or ‘non-functional’, and a human-readable presentation of the underlying evidence allow a biologically meaningful interpretation of the score. The output shows key aspects of every variant and allows rapid access to more detailed information about its possible role in gene regulation. RegulationSpotter can either analyse single variants or complete VCF files. Variants located within protein-coding transcripts are automatically assessed by MutationTaster as well as by RegulationSpotter to account for possible intragenic regulatory effects. RegulationSpotter offers the possibility of using phenotypic data to focus on known disease genes or genomic elements interacting with them. RegulationSpotter is freely available at https://www.regulationspotter.org.
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice
Creators: name: Klocke, Jan
name: Ulu, Arzu
name: Wu, Kaiyin
name: Rudolph, Birgit
name: Dragun, Duska
name: Gollasch, Maik
name: Schunck, Wolf-Hagen
name: Hammock, Bruce D.
name: Riemekasten, Gabriela
name: Enghard, Philipp
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: epoxy fatty acids (EpFAs)
subject: arachidonic acid
subject: kidney
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated. We assessed the influence of EpFAs and their metabolites in lupus prone NZB/W F1 mice by pharmacological inhibition of soluble epoxide hydrolase (sEH, EPHX2). The sEH inhibitor 1770 was administered to lupus prone NZB/W F1 mice in a prophylactic and a therapeutic setting. Prophylactic inhibition of sEH significantly improved survival and reduced proteinuria. By contrast, sEH inhibitor-treated nephritic mice had no survival benefit; however, histological changes were reduced when compared to controls. In humans, urinary EpFA levels were significantly different in 47 SLE patients when compared to 10 healthy controls. Gene expression of EPHX2 was significantly reduced in the kidneys of both NZB/W F1 mice and lupus nephritis (LN) patients. Correlation of EpFAs with SLE disease activity and reduced renal EPHX gene expression in LN suggest roles for these components in human disease.
Conus tessulatus Born 1778
Creators: name: Franklin, J. Benjamin
name: Subramanian, K. A.
name: Fernando, S. Antony
name: Krishnan, K. S.
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Conus
Conus tessulatus

description: 53. Conus tessulatus Born, 1778 (Figure 54)
 Conus tessulatus Born, 1778: 1780 (representation of lectotype, Martini 1773: pl. 59, fig. 653 (Kohn 1964); "Africa").
 Cucullus pavimentum Röding, 1798: 41, no. 509/33 (lectotype same as that of C. tessulatus Born (Kohn 1975); locality unknown).
 Conus edaphus Dall, 1910: 223–224 (holotype, USNM (24.5 x 14 mm) (Röckel et al. 1995); "off Clarion Island").
 Material examined: MBMCS153, 34 specimens, SL 32–70 mm; SW 26–45 mm.
 Description. Shell medium sized to moderately large, solid to moderately heavy. Body whorl conical to broadly conical, outline convex near shoulder, straight below. Shoulder broad, subangulate to angulate. Spire low to moderate height, sharply pointed, outline slightly concave. Aperture moderately narrow and with almost uniform width, outer lip sharp and straight. Body whorl with variously spaced, weak or incised or often punctuate spiral grooves on apical third.
Ground colour white. Body whorl with spiral rows of mostly bright orange rectangular spots or bars, often alternating with white markings. These colour markings usually fuse into spiral bands in each side of the centre. Shoulder and spire with radial markings matching bars on last whorl in size and colour. Base bluish-white. Aperture white, usually with pink tones. Periostracum orange, thin and smooth.
 Distribution. Bruguière (1792) first reported C. tessulatus from the Malabar coast. Dautzenberg (1937) noted a specimen from Madras (at IRSN). Röckel et al. (1995) reported a specimen from Madras and another from India without locality data. Kohn (1978) reported museum deposited specimens collected from Tuticorin (at BMNH) and Tranquebar (at ZMUC).
The specimens described herein were collected by trawling in 5–20 m from stations 4, 5 and 19 and at depths beyond 50 m from other stations (Table 6). In Keelakarai, specimens were collected by diving in 5–8 m on sand and coral rubble bottom.
  Remarks. Conus tessulatus  occurs generally at stations with the large fishing harbours. No depth data from Indian waters was available from the previous reports. However, in this study, C. tessulatus was mostly obtained at depths of 5– 50 m.
description: Published as part of Franklin, J. Benjamin, Subramanian, K. A., Fernando, S. Antony & Krishnan, K. S., 2009, 2250, pp. 1-63 in Zootaxa 2250 on page 47
Electron momentum density in yttrium
Creators: name: Kontrym-Sznajd, G.
name: Samsel-Czekala, M.
name: Pietraszko, A.
name: Sormann, H.
name: Manninen, S.
name: Huotari, S.
name: Hamalainen, K.
name: Laukkanen, J.
name: West, R. N.
name: Schulke, W.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A simultaneous analysis of high-resolution directional Compton profiles and two-dimensional angular correlation of positron annihilation experimental data has been performed by studying both a directional anisotropy of measured spectra and reconstructed densities. The results were compared with theoretical fully-relativistic augmented plane-wave calculations with and without including correlation effects. Estimated symmetry selection rules have allowed us to establish some values of Fermi momenta. Both experiments show exactly the same shape of the anisotropy of the momentum densities, in agreement with the band structure results. In the positron annihilation data electron-positron correlations are not seen while in both experiments electron-electron correlations are observed.
Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report
Creators: name: Soll, Dominik
name: Spira, Dominik
name: Hollstein, Tim
name: Haberbosch, Linus
name: Demuth, Ilja
name: Steinhagen-Thiessen, Elisabeth
name: Bobbert, Thomas
name: Spranger, Joachim
name: Kassner, Ursula
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Lysosomal acid lipase deficiency (LALD)
subject: Cholesteryl ester storage disease
subject: Sebelipase alfa (Kanuma™)
subject: LALD registry
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We report on a case of very rare autosomal recessive cholesteryl ester storage disease due to lysosomal acid lipase deficiency (LALD). LALD is caused by mutations in the lysosomal acid lipase A (LIPA) gene resulting in cholesteryl ester accumulation in liver, spleen, and macrophages. It can lead to liver failure, accelerated atherosclerosis and premature death. Until recently, treatment options were limited to lipid-lowering medications to control dyslipidemia. Presently, a long-term enzyme replacement therapy with Sebelipase alfa, a recombinant human lysosomal acid lipase, is available for patients with LALD. Our patient's condition became conspicuous at the age of two due to a xanthogranuloma of the chin together with increased lipid levels, elevated liver enzymes and hepatomegaly. It took another five years until our patient was diagnosed with LALD after genetic testing. A bi-weekly therapy with intravenous Sebelipase alfa was started at the age of 26 years. It led to normalization of lipid levels, reduction of liver enzymes and beginning regression of hepatomegaly in the absence of adverse drug reactions after 46 infusions. Since LALD can take a fatal course even in patients with a long-term stable condition, it is essential to identify affected patients early and to treat them appropriately by enzyme replacement therapy. LALD should be suspected in patients with low high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) in conjunction with elevated liver enzymes or hepatomegaly. A registry for LALD patients shall help to advance our understanding of the disease as well as improve patient care (NCT01633489).
Tools for the Performance Optimization of Single-Photon Quantum Key Distribution
Creators: name: Kupko, Timm
name: Helversen, Martin v.
name: Rickert, Lucas
name: Schulze, Jan-Hindrik
name: Strittmatter, André
name: Gschrey, Manuel
name: Rodt, Sven
name: Reitzenstein, Stephan
name: Heindel, Tobias
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum light sources emitting triggered single photons or entangled photon pairs have the potential to boost the performance of quantum key distribution (QKD) systems. Proof-of-principle experiments affirmed these prospects, but further efforts are necessary to push this field beyond its current status. In this work, we show that temporal filtering of single-photon pulses enables a performance optimization of QKD systems implemented with realistic quantum light sources, both in experiment and simulations. To this end, we analyze the influence of temporal filtering of sub-Poissonian single-photon pulses on the expected secret key fraction, the quantum bit error ratio, and the tolerable channel losses. For this purpose, we developed a basic QKD testbed comprising a triggered solid-state single-photon source and a receiver module designed for four-state polarization coding via the BB84 protocol. Furthermore, we demonstrate real-time security monitoring by analyzing the photon statistics, in terms of $g^{(2)}(0)$, inside the quantum channel by correlating the photon flux recorded at the four ports of our receiver. Our findings are useful for the certification of QKD and can be applied and further extended for the optimization of various implementations of quantum communication based on sub-Poissonian quantum light sources, including measurement-device-independent schemes of QKD as well as quantum repeaters. Our work represents an important contribution towards the development of QKD-secured communication networks based on quantum light sources.
description: 13 pages, 8 figures, including Supplementary Information; revised version with new results and extended discussions
MOESM2 of Cost-effectiveness of the SLIMMER diabetes prevention intervention in Dutch primary health care: economic evaluation from a randomised controlled trial
Creators: name: Geerke Duijzer
name: Bukman, Andrea
name: Meints-Groenveld, Aafke
name: Haveman-Nies, Annemien
name: Jansen, Sophia
name: Heinrich, Judith
name: Hiddink, Gerrit
name: Feskens, Edith
name: G. Wit
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 2: Figure S1. Cost-effectiveness plane from 1000 bootstrap simulation for the SLIMMER intervention compared to usual health care.