cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The moment of tooth: rate, fate, and pattern of Pacific lingcod dentition revealed by pulse-chase
Creators: name: Carr, Emily
name: Summers, Adam
name: Cohen, Karly
Publisher: name: Zenodo
Year: 2021

description: Tooth replacement rates of polyphyodont cartilaginous and bony fishes are hard to determine because of lack of obvious patterning, and maintaining specimens long enough to observe replacement. Pulse-chase is a fluorescent technique that differentially colours developing mineralized tissue. We present in-situ tooth replacement rate and position data for the oral and pharyngeal detentions of Ophiodon elongatus (Pacific lingcod). We assessed over 10,000 teeth, in 20 fish, and found a daily replacement rate of about two teeth (3.6% of the dentition). The average tooth is in the dental battery for 27 days. Replacement was higher in the lower pharyngeal jaw (LPJ). We found no difference between replacement rates of feeding and non-feeding fish, suggesting feeding was not a driver of tooth replacement. Lingcod teeth have both a size and location fate; smaller teeth at one spot will not grow into larger teeth, even if a large tooth nearby is lost. We also found increased rates of replacement at the posterior of the LPJ relative to the anterior. We propose that lingcod teeth do not migrate in the jaw as they develop; their teeth are fated in size and location, erupting in their functional position.
title: Lerncoaching als Chance für Chancenlose?
Creators: name: Mödritscher, Barbara Christina
Year: 2009

description: Die vorliegende Diplomarbeit setzt sich mit der sozialen und emotionalen Situation von Jugendlichen mit Migrationshintergrund und dem Lerncoachingprojekt MIGRA auseinander. Es wird aufgezeigt, mit welchen Schwierigkeiten die Jugendlichen im Zuge ihrer dualen Ausbildung bzw. integrativen Lehre zu kämpfen haben und inwiefern ein Projekt wie MIGRA bedeutsam für das erfolgreiche Lernen und die emotionale Entwicklung der jungen MigrantInnen ist. Der Status „Ausländer“ zeigt sich, vergleichbar mit dem Etikett „Behinderung“, als hemmendes Element in sozialen Interaktionen und kann ein Hindernis für schulisches Vorankommen und den Eintritt ins Berufsleben darstellen. Die Rolle von Arbeitsintegrationsprojekten und im Speziellen dem Lerncoachingprojekt MIGRA wird in der Arbeit beleuchtet und auf ihre Bedeutung für junge MigrantInnen untersucht. Zu diesem Zweck wird in einem empirischen Teil der Arbeit eine qualitative Analyse von Interviews mit fünf Jugendlichen, die an MIGRA teilgenommen haben bzw. teilnehmen, von der Autorin vorgenommen.
sj-pdf-1-tae-10.1177_20420188231220120 – Supplemental material for Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations
Creators: name: Rout, Madhusmita
name: Wander, Gurpreet S.
name: Ralhan, Sarju
name: Singh, Jai Rup
name: Aston, Christopher E.
name: Blackett, Piers R.
name: Chernausek, Steven
name: Sanghera, Dharambir K.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Endocrinology
Paediatrics
Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-tae-10.1177_20420188231220120 for Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations by Madhusmita Rout, Gurpreet S. Wander, Sarju Ralhan, Jai Rup Singh, Christopher E. Aston, Piers R. Blackett, Steven Chernausek and Dharambir K. Sanghera in Therapeutic Advances in Endocrinology and Metabolism
Additional file 5 of Plastid genome data provide new insights into the dynamic evolution of the tribe Ampelopsideae (Vitaceae)
Creators: name: Zhang, Lei
name: Meng, Ying
name: Wang, Da
name: He, Guan-Hao
name: Zhang, Jun-Ming
name: Wen, Jun
name: Nie, Ze-Long
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Supplementary Material 5.
Additional file 1 of The highlighting divide: does highlighting strategy help explain international gaps in reading achievement?
Creators: name: Anghel, Ella
name: von Davier, Matthias
Publisher: name: figshare
Year: 2025
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 1.
An optimal control framework for the automated design of personalized cancer treatments
Creators: name: Angaroni, Fabrizio
name: Graudenzi, Alex
name: Rossignolo, Marco
name: Maspero, Davide
name: Calarco, Tommaso
name: Piazza, Rocco
name: Montangero, Simone
name: Antoniotti, Marco
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: personalized therapy
subject: optimal control theory
subject: pharmacodynamics
subject: RedCRAB
subject: chronic myeloid leukemia
subject: DDC 610 / Medicine & health
subject: Neoplasms; Drug therapy
subject: Precision medicine
subject: Pharmacokinetics
subject: Krebs
subject: Chronisch-myeloische Leukämie
subject: Individualisierte Medizin
subject: Pharmakokinetik

description: One of the key challenges in current cancer research is the development of computational strategies to support clinicians in the identification of successful personalized treatments. Control theory might be an effective approach to this end, as proven by the long-established application to therapy design and testing. In this respect, we here introduce the Control Theory for Therapy Design (CT4TD) framework, which employs optimal control theory on patient-specific pharmacokinetics (PK) and pharmacodynamics (PD) models, to deliver optimized therapeutic strategies. The definition of personalized PK/PD models allows to explicitly consider the physiological heterogeneity of individuals and to adapt the therapy accordingly, as opposed to standard clinical practices. CT4TD can be used in two distinct scenarios. At the time of the diagnosis, CT4TD allows to set optimized personalized administration strategies, aimed at reaching selected target drug concentrations, while minimizing the costs in terms of toxicity and adverse effects. Moreover, if longitudinal data on patients under treatment are available, our approach allows to adjust the ongoing therapy, by relying on simplified models of cancer population dynamics, with the goal of minimizing or controlling the tumor burden. CT4TD is highly scalable, as it employs the efficient dCRAB/RedCRAB optimization algorithm, and the results are robust, as proven by extensive tests on synthetic data. Furthermore, the theoretical framework is general, and it might be applied to any therapy for which a PK/PD model can be estimated, and for any kind of administration and cost. As a proof of principle, we present the application of CT4TD to Imatinib administration in Chronic Myeloid leukemia, in which we adopt a simplified model of cancer population dynamics. In particular, we show that the optimized therapeutic strategies are diversified among patients, and display improvements with respect to the current standard regime.
Chem/bio sensing with non-classical light and integrated photonics
Creators: name: Haas, Julian
name: Schwartz, Mario
name: Rengstl, Ulrich
name: Jetter, Michael
name: Michler, Peter
name: Mizaikoff, Boris
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Chem/bio sensing
subject: Non-classical light
subject: Integrated photonics
subject: Quantum technology
subject: Infrared quantum photonics
subject: Chem/bio sensors
subject: On-chip chem/bio quantum photonic sensing
subject: DDC 500 / Natural sciences & mathematics
subject: Biosensors
subject: Chemical detectors
subject: Photonics
subject: Integrated optics
subject: Biosensor
subject: Chemischer Sensor
subject: Photonik
subject: Integrierte Optik

description: Modern quantum technology currently experiences extensive advances in applicability in communications, cryptography, computing, metrology and lithography. Harnessing this technology platform for chem/bio sensing scenarios is an appealing opportunity enabling ultra-sensitive detection schemes. This is further facilliated by the progress in fabrication, miniaturization and integration of visible and infrared quantum photonics. Especially, the combination of efficient single- photon sources together with waveguiding/sensing structures, serving as active optical transducer, as well as advanced detector materials is promising integrated quantum photonic chem/bio sensors. Besides the intrinsic molecular selectivity and non-destructive character of visible and infrared light based sensing schemes, chem/bio sensors taking advantage of non-classical light sources promise sensitivities beyond the standard quantum limit. In the present review, recent achievements towards on-chip chem/bio quantum photonic sensing platforms based on N00N states are discussed along with appropriate recognition chemistries, facilitating the detection of relevant (bio)analytes at ultra-trace concentration levels. After evaluating recent developments in this field, a perspective for a potentially promising sensor testbed is discussed for reaching integrated quantum sensing with two fiber-coupled GaAs chips together with semiconductor quantum dots serving as single-photon sources
Additional file 1 of A “silent storm”: uncovering the escalating crisis in mental healthcare for children and adolescents in Slovenia during and after the COVID-19 pandemic
Creators: name: Zupanič Mali, Sanja
name: Karakatič, Sašo
name: Drobnič Radobuljac, Maja
Publisher: name: figshare
Year: 2025
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Supplementary Material 1
Atom interferometry with quantized light pulses
Creators: name: Soukup, Katharina
name: Di Pumpo, Fabio
name: Aßmann, Tobias
name: Schleich, Wolfgang P.
name: Giese, Enno
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Quantized light field
subject: DDC 530 / Physics
subject: Atom interferometry
subject: Quantum optics
subject: Quantenoptik

description: The far-field patterns of atoms diffracted from a classical light field or from a quantum one in a photon-number state are identical. On the other hand, diffraction from a field in a coherent state, which shares many properties with classical light, displays a completely different behavior. We show that in contrast to the diffraction patterns, the interference signal of an atom interferometer with light-pulse beam splitters and mirrors in intense coherent states does approach the limit of classical fields. However, low photon numbers reveal the granular structure of light, leading to a reduced visibility since welcher-Weg (which-way) information is encoded into the field. We discuss this effect for a single photon-number state as well as a superposition of two such states.
Impact of X-ray exposure on the proliferation and differentiation of human pre-adipocytes
Creators: name: Shreder, Kateryna
name: Rapp, Felicitas
name: Tsoukala, Ioanna
name: Rzeznik, Vanessa
name: Wabitsch, Martin
name: Fischer-Posovszky, Pamela
name: Fournier, Claudia
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: adipogenic differentiation
subject: SGBS
subject: low dose radiation therapy
subject: radiation response
subject: photon irradiation
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 570 / Life sciences
subject: Radiotherapy
subject: Adipocytes
subject: Adipokines
subject: Radiation dosage
subject: Radiation exposure
subject: Strahlentherapie
subject: Strahlendosis
subject: Fettzelle
subject: Adipokine

description: Radiotherapy is a widely used treatment option for cancer patients as well as for patients with musculoskeletal disorders. Adipocytes, the dominant cell type of adipose tissue, are known to constitute an active part of the tumor microenvironment. Moreover, adipocytes support inflammatory processes and cartilage degradation in chronic inflammatory diseases, i.e., rheumatoid and osteoarthritis. Since the production of inflammatory factors is linked to their differentiation stages, we set out to explore the radiation response of pre-adipocytes that may influence their inflammatory potential and differentiation capacity. This is the first study investigating the effects of X-ray irradiation on the proliferation and differentiation capacity of human primary pre-adipocytes, in comparison to Simpson–Golabi–Behmel Syndrome (SGBS) pre-adipocytes, an often-used in vitro model of human primary pre-adipocytes. Our results demonstrate a dose-dependent reduction of the proliferation capacity for both cell strains, whereas the potential for differentiation was mostly unaffected by irradiation. The expression of markers of adipogenic development, such as transcription factors (PPARγ, C/EBPα and C/EBPβ), as well as the release of adipokines (visfatin, adiponectin and leptin) were not significantly changed upon irradiation. However, after irradiation with high X-ray doses, an increased lipid accumulation was observed, which suggests a radiation-induced response of adipocytes related to inflammation. Our results indicate that pre-adipocytes are radio-resistant, and it remains to be elucidated whether this holds true for the overall inflammatory response of adipocytes upon irradiation.
Supplemental Material - Using Independent Contracting Arrangements in Integrated Care Programs for Older Adults: Implications for Clients and the Home Care Workforce in a Time of Neoliberal Restructuring
Creators: name: Kehoe MacLeod, Krystal
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material for Using Independent Contracting Arrangements in Integrated Care Programs for Older Adults: Implications for Clients and the Home Care Workforce in a Time of Neoliberal Restructuring by Krystal Kehoe MacLeod in Journal of Applied Gerontology
Tailoring formulations for intranasal nose-to-brain delivery: a review on architecture, physico-chemical characteristics and mucociliary clearance of the nasal olfactory mucosa
Creators: name: Gänger, Stella
name: Schindowski, Katharina
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: olfactory epithelium
subject: respiratory epithelium
subject: NALT
subject: semisolid
subject: CNS drug delivery
subject: biopharmaceuticals
subject: dosage form
subject: medical device
subject: DDC 610 / Medicine & health
subject: Central nervous system diseases; Drug therapy
subject: Drug delivery systems
subject: Blood-brain barrier
subject: Respiratory mucosa
subject: Olfactory mucosa
subject: Nanoparticles
subject: Zentralnervensystem
subject: Targeted drug delivery
subject: Blut-Hirn-Schranke
subject: Bronchialschleimhaut
subject: Nasenschleimhaut
subject: Nanopartikel

description: The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in central nervous system (CNS) drug delivery, since they block most molecules from entering the brain. Alternative drug delivery routes like intraparenchymal or intrathecal are invasive methods with a remaining risk of infections. In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain. In particular, the skull base located at the roof of the nasal cavity is in close vicinity to the CNS. This area is covered with olfactory mucosa. To design and tailor suitable formulations for nose-to-brain drug delivery, the architecture, structure and physico-chemical characteristics of the mucosa are important criteria. Hence, here we review the state-of-the-art knowledge about the characteristics of the nasal and, in particular, the olfactory mucosa needed for a rational design of intranasal formulations and dosage forms. Also, the information is suitable for the development of systemic or local intranasal drug delivery as well as for intranasal vaccinations.
Die Messungen der Obliquität
Creators: name: Keim, Frank
name: Seemann, Dominik
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Knochenflöte
subject: Prähistorische Kunst
subject: Prehistoric figurine
subject: DDC 930 / History of the ancient world (to ca. 499)
subject: Bone flute
subject: Lion man (Prehistoric figurine)
subject: Figurines, Prehistoric
subject: Sphinx
subject: Achtal
subject: Adorant
subject: Archäologie
subject: Eiszeitkunst
subject: GeoPark Schwäbische Alb
subject: Jungpaläolithikum
subject: Löwenmensch
subject: Präzession
subject: Steinzeit
subject: Stellarastronomie
subject: Venus vom Hohlefels

description: Zusammenfassung: Mit der Venus vom Hohle Fels beginnt vor 40.000 Jahren die planetarische Astronomie. In diese Zeit fallen Funde von Flöten – die ersten Musikinstrumente der Welt. Der berühmte Löwenmensch eröffnet die stellare Phase, in deren Zentrum die lunisolare Präzession steht. Wir stoßen erstmals auf die Sternbilder Löwe, Krebs, Widder und Steinbock. Gegen Ende des Aurignacien verlagerte sich das Interesse zur Sonne. Seit der Venus vom Galgenberg (36.000 Jahre) liegen erstmals Messungen der Ekliptikebene vor. Diskutiert werden außerdem die Venusstatuetten aus Laussel (Frankreich) und Dolni Vestonice (Tschechien).
description: Summary: The Venus from Hohle Fels (Germany) from 40.000 B.P. was the starting point for the planetary astronomy. In the same period flutes has been found – the first musical instruments of mankind. The famous lion-man opened the stellar phase in which the lunisolar precession was central. We will meet the constellations of Leo, Cancer, Aries and Capricornus. At the end of the Aurignacien the interest changed to the sun. Since the Venus of Galgenberg (36.000 B.P.) we registrate measurements of the obliquity of the ecliptic. Furthermore, we discuss figures of Venus from Laussel (France) and Dolni Vestonice (Czech Republic).
Paraphlomis longicalyx (Lamiaceae), a new species from the limestone area of Guangxi and Guizhou Provinces, southern China
Creators: name: Chen, Ya-Ping
name: Sun, Zeng-Peng
name: Xiao, Jin-Fei
name: Yan, Ke-Jian
name: Xiang, Chun-Lei
Publisher: name: Zenodo
Year: 2021

description: Consisting of approximately 30 species, the genus Paraphlomis of the mint family are mostly restricted to the subtropical area of China. In this study, Paraphlomis longicalyx, a new species from southern China, is described and illustrated. Molecular phylogenetic studies were carried out to investigate the placement of the new species within Paraphlomis based on two nuclear ribosomal DNA and four plastid DNA regions. The results show that P. longicalyx is recovered as a distinct lineage within the genus. Morphologically, the new species is similar to P. javanica and P. foliata, but can be distinguished by its densely hispidulous plants, much longer calyces, and pale-yellow corollas with reddish-purple spots on the lower lips.
description: Funding provided by: National Natural Science Foundation of China
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001809
Award Number: 31800168Funding provided by: National Natural Science Foundation of China
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001809
Award Number: 31872648Funding provided by: Yunnan Fundamental Research Projects*
Crossref Funder Registry ID:
Award Number: 2019FI009Funding provided by: Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100018576
Award Number: YNWR-QNBJ-2018-279Funding provided by: Yunnan Fundamental Research Projects
Crossref Funder Registry ID:
Award Number: 2019FI009
Targeting DNA damage repair mechanisms in pancreas cancer
Creators: name: Perkhofer, Lukas
name: Golan, Talia
name: Cuyle, Pieter-Jan
name: Matysiak-Budnik, Tamara
name: Van Laethem, Jean-Luc
name: Macarulla, Teresa
name: Cauchin, Estelle
name: Kleger, Alexander
name: Beutel, Alica K.
name: Gout, Johann
name: Stenzinger, Albrecht
name: Van Cutsem, Eric
name: Bellmunt, Joaquim
name: Hammel, Pascal
name: O’Reilly, Eileen M.
name: Seufferlein, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: pancreatic ductal adenocarcinoma
subject: PARP inhibition
subject: platinum
subject: homologous repair deficiency
subject: BRCA1/2
subject: DDC 610 / Medicine & health
subject: Pancreatic neoplasms
subject: DNA damage
subject: DNA repair
subject: Homologous recombination
subject: Bauchspeicheldrüsenkrebs
subject: DNS-Schädigung
subject: DNS-Reparatur
subject: Gen BRCA 1
subject: Gen BRCA 2

description: Impaired DNA damage repair (DDR) is increasingly recognised as a hallmark in pancreatic ductal adenocarcinoma (PDAC). It is estimated that around 14% of human PDACs harbour mutations in genes involved in DDR, including, amongst others, BRCA1/2, PALB2, ATM, MSH2, MSH6 and MLH1. Recently, DDR intervention by PARP inhibitor therapy has demonstrated effectiveness in germline BRCA1/2-mutated PDAC. Extending this outcome to the significant proportion of human PDACs with somatic or germline mutations in DDR genes beyond BRCA1/2 might be beneficial, but there is a lack of data, and consequently, no clear recommendations are provided in the field. Therefore, an expert panel was invited by the European Society of Digestive Oncology (ESDO) to assess the current knowledge and significance of DDR as a target in PDAC treatment. The aim of this virtual, international expert meeting was to elaborate a set of consensus recommendations on testing, diagnosis and treatment of PDAC patients with alterations in DDR pathways. Ahead of the meeting, experts completed a 27-question survey evaluating the key issues. The final recommendations herein should aid in facilitating clinical practice decisions on the management of DDR-deficient PDAC.
Additional file 1 of Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties
Creators: name: Abdelwahab, Reham E.
name: Elwahy, Ahmed H. M.
name: Ibrahim, Nada S.
name: Abdelmoniem, Amr M.
name: Abdelhamid, Ismail A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Additional file 1 of ‘It’s about time’: policymakers’ and health practitioners’ perspectives on implementing fertility care in the Gambian health system
Creators: name: Afferri, Anna
name: Dierickx, Susan
name: Allen, Haddijatou
name: Bittaye, Mustapha
name: Marena, Musa
name: Pacey, Allan
name: Balen, Julie
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Computational Biology

description: Supplementary Material 1: A1? Interview guides
sj-docx-4-npx-10.1177_1934578X221120215 - Supplemental material for Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of Qi Wei Wan Formula for Treating Non-Small Cell Lung Carcinoma
Creators: name: Zhang, Minghe
name: Wang, Ye
name: Amin, Aftab
name: Khan, Muhammad Ajmal
name: Yu, Zhiling
name: Liang, Chun
Publisher: name: SAGE Journals
Year: 2022
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-4-npx-10.1177_1934578X221120215 for Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of Qi Wei Wan Formula for Treating Non-Small Cell Lung Carcinoma by Minghe Zhang, Ye Wang, Aftab Amin, Muhammad Ajmal Khan, Zhiling Yu and Chun Liang in Natural Product Communications
The effects of a standardized cognitive-behavioural therapy and an additional mindfulness-based training on interoceptive abilities in a depressed cohort
Creators: name: Karanassios, Georgios
name: Schultchen, Dana
name: Möhrle, Matthias
name: Berberich, Götz
name: Pollatos, Olga
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: MBSR
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Mindfulness-based cognitive therapy
subject: Interoception
subject: Cognitive behavioral therapy
subject: Mindfulness; Methods
subject: Depressive disorder; Therapy
subject: Interozeption
subject: Kognitive Verhaltenstherapie
subject: Achtsamkeitsbasierte Stressreduktion
subject: Depression

description: Background: Interoceptive accuracy and sensibility are decreased in depressive samples. However, different studies showed that cognitive-behavioural therapy (CBT) and mindfulness interventions are promising approaches to improve interoceptive abilities. Based on these findings, the study aims to investigate the pre–post effect of CBT in a depressive sample. Additionally, we examined the effect of mindfulness-based stress reduction (MBSR) training in the context of CBT. Methods: Sixty depressive patients were investigated over four weeks, with two conditions—CBT vs. CBT + MBSR. Further, the changes in interoceptive abilities (interoceptive accuracy and sensibility) of the depressive patients were compared to baseline data of healthy controls. Results: The depressive patients showed significantly higher levels of depression and lower mindfulness and interoceptive abilities than healthy controls. The depressive sample showed a significant decrease in depressive symptoms and increased mindfulness and interoceptive abilities after CBT. Lastly, depressive patients of the CBT + MBSR condition did not differ from those who only received CBT in the levels of depression, mindfulness or interoceptive abilities over the time course. Discussion: This study demonstrates a positive effect of CBT on interoceptive abilities in a depressive sample. It is shown that the depressive sample did not profit from additional mindfulness training. It can be concluded that CBT is an efficient treatment, resulting in increased interoceptive abilities. Unexpectedly, the combination of CBT and MBSR has no additional effect on these changes. Future studies should investigate the effect of MBSR as a stand-alone therapy.
sj-pdf-9-pie-10.1177_09544089221126439 - Supplemental material for Radiative flow of nanofluid past a convected vertical Riga plate with activation energy and nonlinear heat generation
Creators: name: Alhowaity, Awatif
name: Mehmood, Yasir
name: Hamam, Haneen
name: Bilal, Muhammad
Publisher: name: SAGE Journals
Year: 2022
Subjects: Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-9-pie-10.1177_09544089221126439 for Radiative flow of nanofluid past a convected vertical Riga plate with activation energy and nonlinear heat generation by Awatif Alhowaity, Yasir Mehmood, Haneen Hamam and Muhammad Bilal in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Additional file 1 of A “silent storm”: uncovering the escalating crisis in mental healthcare for children and adolescents in Slovenia during and after the COVID-19 pandemic
Creators: name: Mali, Sanja Zupanič
name: Karakatič, Sašo
name: Radobuljac, Maja Drobnič
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Supplementary Material 1
Additional file 2 of ‘It’s about time’: policymakers’ and health practitioners’ perspectives on implementing fertility care in the Gambian health system
Creators: name: Afferri, Anna
name: Dierickx, Susan
name: Allen, Haddijatou
name: Bittaye, Mustapha
name: Marena, Musa
name: Pacey, Allan
name: Balen, Julie
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Computational Biology

description: Supplementary Material 2: A2? COREQ checklist
Auditing Bias in Large Language Models
Creators: name: Robinson, Katherine-Marie
name: Turri, Violet
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: Software Engineering

description: How do you analyze a large language model (LLM) for harmful biases? The 2022 release of ChatGPT launched LLMs onto the public stage. Applications that use LLMs are suddenly everywhere, from customer service chatbots to LLM-powered healthcare agents. Despite this widespread use, concerns persist about bias and toxicity in LLMs, especially with respect to protected characteristics such as race and gender.  In this blog post, we discuss our recent research that uses a role-playing scenario to audit ChatGPT, an approach that opens new possibilities for revealing unwanted biases. At the SEI, we’re working to understand and measure the trustworthiness of artificial intelligence (AI) systems. When harmful bias is present in LLMs, it can decrease the trustworthiness of the technology and limit the use cases for which the technology is appropriate, making adoption more difficult. The more we understand how to audit LLMs, the better equipped we are to identify and address learned biases.
How can nanoparticle‐based technologies revolutionize the topical therapy in psoriasis?
Creators: name: Sindrilaru, Anca
name: Filip, Adriana
name: Scharffetter‐Kochanek, Karin
name: Crisan, Diana
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: green technology
subject: inflammation models
subject: nanomaterials
subject: pro‐inflammatory cytokines
subject: skin‐directed treatment
subject: DDC 610 / Medicine & health
subject: Psoriasis; Drug therapy
subject: Inflammation
subject: Schuppenflechte
subject: Pharmakotherapie

description: Abstract Psoriasis is one of the most common dermatoses with a heterogeneous pathogenesis which can be successfully exploited therapeutically as it is increasingly well understood. Topical therapy is the gold standard for psoriasis patients with mild disease courses and for complementary and maintenance treatment in moderate and severe forms. However, while new systemic therapies are rapidly implemented in the daily routine as our pathomechanistic understanding of psoriasis evolves, the development of topical psoriasis therapies stagnates. Modern topical treatments though would require not only new active substances but also improved galenics. Due to their unique ability to directly exert biological functions, but also to deliver drugs in optimal concentrations, enabling increased therapeutic efficacy, reduced adverse effects and improved patient compliance, nanoparticles may represent ideal drug carriers for local therapeutics in psoriasis. In recent years, a series of reports added important insights into the biology of skin‐nanoparticles interactions and on how they impact the epidermal and dermal inflammatory compartments in vitro and in psoriasis plaques. Furthermore, by targeting anti‐inflammatory substances to specific skin compartments, nanotechnological advances offer the exciting opportunity to fine‐tune skin inflammation at molecular and cellular levels, paving the road to a high‐precision, skin‐directed topical therapy in psoriasis. However, nanoparticle‐based therapies have not yet found their way into clinical routine in dermatology. We here resume the current advances in the research of nanoparticles and skin inflammation in general and psoriasis in particular and discuss how this promising technology should develop in order to fulfil the requirements of an optimal skin therapy.
Additional file 3 of ‘It’s about time’: policymakers’ and health practitioners’ perspectives on implementing fertility care in the Gambian health system
Creators: name: Afferri, Anna
name: Dierickx, Susan
name: Allen, Haddijatou
name: Bittaye, Mustapha
name: Marena, Musa
name: Pacey, Allan
name: Balen, Julie
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Computational Biology

description: Supplementary Material 3: A3? Thematic analysis codebook
sj-docx-2-pch-10.1177_21501351231211590 - Supplemental material for Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children: A Randomized Controlled Trial
Creators: name: Rahmat, Budi
name: Siswanto, Bambang Budi
name: Fakhri, Dicky
name: Sakidjan, Indriwanto
name: Murni, Tri Wahyu
name: Timan, Ina Susianti
name: Kekalih, Aria
name: Kurniawati, Yovi
name: Fardhani, Dwi Gunawan
name: Arya Wardana, Putu Wisnu
Publisher: name: SAGE Journals
Year: 2023
Subjects: Cardiology
Paediatrics
Surgery

description: Supplemental material, sj-docx-2-pch-10.1177_21501351231211590 for Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children: A Randomized Controlled Trial by Budi Rahmat, Bambang Budi Siswanto, Dicky Fakhri, Indriwanto Sakidjan, Tri Wahyu Murni, Ina Susianti Timan, Aria Kekalih, Yovi Kurniawati, Dwi Gunawan Fardhani and Putu Wisnu Arya Wardana in World Journal for Pediatric and Congenital Heart Surgery
Additional file 2 of The highlighting divide: does highlighting strategy help explain international gaps in reading achievement?
Creators: name: Anghel, Ella
name: von Davier, Matthias
Publisher: name: figshare
Year: 2025
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 2.
Controlling an intelligent operating room with spoken language
Creators: name: Gerstenlauer, Nadine
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Intelligent environments
subject: Intelligent operating assistance
subject: Voice interaction systems
subject: Surgical environment
subject: Natural spoken language
subject: DDC 004 / Data processing & computer science
subject: Human-computer interaction
subject: Surgery, computer-assisted; Methods
subject: Sprachdialogsystem
subject: Assistenzsystem
subject: Mensch-Maschine-Kommunikation
subject: Operationssaal

description: With the emergence of new technologies, the surgical working environment becomes increasingly complex and comprises many medical devices which have to be taken care of. However, the operating personnel cannot be extended infinitely, which is why new strategies are needed for keeping the working environment manageable. Existing research projects in the field of intelligent medical environments mostly concentrate on workflow modelling or single smart features rather than building up a complete Intelligent Environment. In this work, we present an intelligent spoken language operation assistant, providing the surgeon assistance in many different situations before and during an ongoing procedure. The speech interface enables the surgeon to concentrate on the surgery and control the technical environment at the same time, without taking care of how to interact with the system. Furthermore, the implemented system observes the context of the surgery and controls several devices autonomously at the appropriate time during the procedure.
Data archiving and sharing survey
Creators: name: Mulligan, Connie
Publisher: name: Zenodo
Year: 2021

description: Open data sharing improves the quality and reproducibility of scholarly research. Open data are defined as data that can be freely used, reused, and redistributed by anyone. Open data sharing democratizes science by making data more equitably available throughout the world regardless of funding or access to other resources necessary for generating cutting-edge data. For an interdisciplinary field like biological anthropology, data sharing is critical since one person cannot easily collect data across multiple domains. The goal of this paper is to encourage broader data sharing by exploring the state of data sharing in the field of biological anthropology. Our paper is divided into four parts: the first section describes the benefits, challenges, and emerging solutions to open data sharing; the second section presents the results of our data archiving and sharing survey that was completed by over 700 researchers; the third section presents personal experiences of data sharing by the authors; and the fourth section discusses the strengths of different types of data repositories and provides a list of recommended data repositories. The data archiving and sharing survey and the raw data collected from the survey are deposited here.
description: Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: BCS 1826885
description: An online survey was developed to query researchers on their attitudes and practices with data archiving and sharing across biological anthropology and related fields. The survey was administered through Qualtrics and was open from May 23 – July 18, 2021. The link to the survey was sent via listserv and/or posted on the website of 19 professional societies and informal groups interested in data sharing. Responses from 722 participants were received and the full Qualtrics survey report is available at https://ql.tc/4reI82. The raw data as exported from Qualtrics (Excel file) and the full survey (Word file) are deposited in this submission.
Transport of ions in a segmented linear Paul trap in printed-circuit-board technology
Creators: name: Huber, G.
name: Deuschle, T.
name: Schnitzler, W.
name: Reichle, R.
name: Singer, K.
name: Schmidt-Kaler, F.
Publisher: name: Universität Ulm
Year: 2008
Subjects: subject: DDC 530 / Physics
subject: Trapped ions
subject: Ionenfalle

description: We describe the construction and operation of a segmented linear Paul trap, fabricated in printed-circuit-board technology with an electrode segment width of 500 μm. We prove the applicability of this technology to reliable ion trapping and report the observation of Doppler-cooled ion crystals of 40Ca+ with this kind of trap. Measured trap frequencies agree with numerical simulations at the level of a few percent from which we infer a high fabrication accuracy of the segmented trap. To demonstrate its usefulness and versatility for trapped ion experiments we study the fast transport of a single ion. Our experimental results show a success rate of 99.0(1)% for a transport distance of 2×2 mm in a round-trip time of T = 20 μs, which corresponds to 4 axial oscillations only. We theoretically and experimentally investigate the excitation of oscillations caused by fast ion transports with error-function voltage ramps: for a slightly slower transport (a round-trip shuttle within T = 30 μs) we observe non-adiabatic motional excitation of 0.89(15) meV.
Die Kopernikus-Porträts Giorgiones und Raffaels
Creators: name: Keim, Frank
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Giorgio da Castelfranco
subject: DDC 100 / Philosophy
subject: Copernicus, Nicolaus 1473-1543; Portraits
subject: Bildnismalerei
subject: Giorgione
subject: Kopernikus, Nikolaus
subject: Raffaello

description: According to Wasiutynski Nicolaus Copernicus is recognized in the "Bildnis eines jungen Mannes" (Berlin). The astronomer from Thorn, staying in Padua since 1501, was portrayed by Giorgione. The second portrait can be found in the School of Athens, Raphael´s canonical masterpiece.
Additional file 1 of Reduction of cardiovascular risk factors by the diet – Evaluation of the MoKaRi concept by a parallel-designed randomized study
Creators: name: Dawczynski, Christine
name: Drobner, Timo
name: Weidauer, Thomas
name: Schlattmann, Peter
name: Kiehntopf, Michael
name: Weber, Daniela
name: Grune, Tilman
name: März, Winfried
name: Kleber, Marcus E.
name: Lorkowski, Stefan
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Table S1. Biochemical methods [52–54].
Successful long-term prophylactic treatment with subcutaneous C1 esterase inhibitor in a patient with hereditary angioedema
Creators: name: Hahn, Janina
name: Nordmann-Kleiner, Melanie
name: Trainotti, Susanne
name: Hoffmann, Thomas K.
name: Greve, Jens
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: C1 inhibitor
subject: DDC 610 / Medicine & health
subject: Angioedemas, Hereditary; Therapy
subject: Complement C1 inhibitor protein
subject: Bradykinin
subject: Hereditäres Angioödem
subject: Therapie
subject: Komplement C1
subject: Bradykinin

description: Background: Hereditary angioedema (HAE) patients suffer from recurrent swellings. Current standard therapy consists of C1 esterase inhibitor (C1-INH) and bradykinin receptor B2 antagonists. Severe courses require prophylactic treatment. For such patients, it has been demonstrated that the intravenous (IV) administration of C1-INH [C1-INH(IV)] is safe and effective. A new prophylactic option is subcutaneous (SC) treatment with C1-INH. Methods and Case: We present the case of an HAE patient placed on prophylactic C1-INH(IV) therapy due to frequent attacks when managed with on-demand therapy. An implanted port allowed the periodical and safe application of medication until the device was explanted due to an infection. Due to the poor venous access, repeated IV application failed. Therefore, we began a SC treatment with 1500 IU C1-INH [C1-INH(SC)] as long-term prophylaxis and analyzed the clinical course over 16 months. Results: Under the SC prophylaxis, the number of attacks were reduced to 1/month in comparison to 4.33/month with no prophylactic treatment and 1.83/month with C1-INH(IV). No severe attacks and no attack within the upper airway occurred over the 16 months of C1-INH(SC) treatment. As a result, quality of life improved, as measured by the Angioedema quality of life questionaire (AE-QoL). Conclusion: Self-administered SC prophylactic use of C1-INH over a period of 16 months seems to be a well tolerated and efficient. The patient’s quality of life improved, and by learning self-application, the patient gained independence.
title: Emanzipation und Agency
title: Das Computerspiel als exemplarische Neuverhandlung gesellschaftlicher Ordnung
titleType: Subtitle
Creators: name: Unterhuber, Tobias
Publisher: name: Graduate School Practices of Literature
Year: 2017
Subjects: 800 Literatur, Rhetorik, Literaturwissenschaft

description: Ausgehend von der Behauptung, dass ›die Frau‹ und Spiel in der Moderne den Mann in die Kultur bringen, ohne selbst Teil von Kultur zu sein, soll aufgezeigt werden, dass das Computerspiel sich nicht zufällig als Aushandlungsort von Gleichberechtigung und Emanzipation und damit als Ort des Kulturkampfes ergibt, sondern dies in seiner spezifischen Medialität begründet ist.
title: Die medizinische Versorgung der Bezirkshauptstadt Mistelbach a.d. Zaya vom 14. bis 20. Jahrhundert
Creators: name: Riegler, Melitta
Year: 2009

description: Beantwortung der Fragestellungen aus der Einleitung - Zusammenfassung auf 7 Seiten.
title: Auditing Bias in Large Language Models
Creators: name: Robinson, Katherine-Marie
name: Turri, Violet
Publisher: name: Software Engineering Institute
publisherIdentifier: https://ror.org/01xqjjn94
publisherIdentifierScheme: ROR
Year: 2024

description: How do you analyze a large language model (LLM) for harmful biases? This blog post from the Carnegie Mellon University Software Engineering Institute discusses recent research that uses a role-playing scenario to audit ChatGPT, an approach that opens new possibilities for revealing unwanted biases.
Additional file 1 of Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Creators: name: Suzuki, Hidefumi
name: Egawa, Naohiro
name: Imamura, Keiko
name: Kondo, Takayuki
name: Enami, Takako
name: Tsukita, Kayoko
name: Suga, Mika
name: Yada, Yuichiro
name: Shibukawa, Ran
name: Takahashi, Ryosuke
name: Inoue, Haruhisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Mental Health

description: Additional file 1: Figure S1. Characterization of the iPSCs. A Representative images of iPSCs showing embryonic stem cells (ESCs)-like morphology (phase images) and expression of the pluripotent stem cell markers TRA-1-60, SSEA4, NANOG. Three iPSC lines were established from healthy individuals (CTL#, CTL#2, and CTL#3) and Parkinson’s disease (PD) patients carrying SNCA A53T mutation (PD#1, PD#2-1, and PD#2-2), respectively. Scale bar = 100 μm. B DNA sequencing analysis illustrating a heterozygous mutation (c.G209A), which resulted in p.A53T mutation in the SNCA gene of the iPSCs derived from the PD patients. C Representative images of in vitro embryoid body formation assay showing the expression of an ectoderm marker (TUBB3), an endoderm marker (SOX17), and a mesoderm marker (αSMA). Scale bar = 100 μm. Figure S2. Characterization of the cortical neurons related to α-Syn. A SNCA mRNA expression analyzed by real-time qPCR on day 8 after neuronal induction (n = 3 biological replicates; two-tailed Student’s t-test; N.S. not significant). B, C Full lengths of western blot images for Figure 1C. D Representative low-magnification images obtained with anti-α-Syn oligomer specific antibodies in cortical neurons. Scale bar = 200 μm. E Orthogonal view of α-Syn-positive small aggregates (red) detected with anti-α-Syn oligomer specific antibodies in PD#1-derived cortical neurons (green). Scale bar = 20 μm. Figure S3. Full-length western blot images related to MAPK cascades. A–C Full-length blot images for Fig. 4A. D–F Full length blot images for Fig. 4C. G–I Full length blot images for Fig. 4E. Table S1. List of the iPSC lines.
Additional file 1 of Increased maternal consumption of methionine as its hydroxyl analog improves placental angiogenesis and antioxidative capacity in sows
Creators: name: Zhou, Rui
name: Lai, Shanshan
name: Yuan, Peiqiang
name: Zhe, Li
name: Yang, Lunxiang
name: Mercier, Yves
name: Hu, Liang
name: Zhang, Xiaoling
name: Hua, Lun
name: Zhuo, Yong
name: Xu, Shengyu
name: Lin, Yan
name: Feng, Bin
name: Che, Lianqiang
name: Wu, De
name: Fang, Zhengfeng
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Fig. S1. The protein detection for placental samples.