cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kappa Snyder deformations of Minkowski spacetime, realizations and Hopf algebra
Creators: name: Meljanac, Stjepan
name: Meljanac, Daniel
name: Samsarov, Andjelo
name: Stojic, Marko
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present Lie-algebraic deformations of Minkowski space with undeformed Poincaré algebra. These deformations interpolate between Snyder and $κ$-Minkowski space. We find realizations of noncommutative coordinates in terms of commutative coordinates and derivatives. By introducing modules, it is shown that although deformed and undeformed structures are not isomorphic at the level of vector spaces, they are however isomorphic at the level of Hopf algebraic action on corresponding modules. Invariants and tensors with respect to Lorentz algebra are discussed. A general mapping from $κ$-deformed Snyder to Snyder space is constructed. Deformed Leibniz rule, the Hopf structure and star product are found. Special cases, particularly Snyder and $κ$-Minkowski in Maggiore-type realizations are discussed. The same generalized Hopf algebraic structures are as well considered in the case of an arbitrary allowable kind of realisation and results are given perturbatively up to second order in deformation parameters.
description: 38 pages, LaTeX2e class file
Stability of anterior vertebral body screws after kyphoplasty augmentation : An experimental study to compare anterior vertebral body screw fixation in soft and cured kyphoplasty cement
Creators: name: Linhardt, O.
name: Lüring, C.
name: Matussek, J.
name: Hamberger, C.
name: Herold, T.
name: Plitz, W.
name: Grifka, J.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: The goal of this cadaver study was to compare the stability of anterior vertebral body screws after implantation in soft or cured kyphoplasty cement. Anterior vertebral body screws were inserted in a total of 30 thoracolumbar vertebrae of ten different human specimens: ten screws were implanted in non-augmented vertebrae (group 1), ten screws were placed in soft cement (group 2), and ten screws were placed in cured cement (group 3). The screws were then tested for biomechanical axial pullout resistance. Mean axial pullout strength was 192 N (range: 10-430 N) in group 1, 364 N (range: 65-875 N) in group 2, and 271 N (range: 35-625 N) in group 3. The paired Student's t-test demonstrated a significant difference between pullout strength of groups 1 and 2 (p= 0.0475). No significant difference was seen between pullout strength of groups 1 and 3 (p= 0.2646) and between groups 2 and 3 (p= 0.3863). We achieved a 1.9 times higher pullout strength with kyphoplasty augmentation of osteoporotic vertebrae compared with the pullout strength of non-augmented vertebrae. Implantation of anterior vertebral body screws in cured cement is a satisfactory method. With this method we found a 1.4 times higher pullout strength than non-augmented vertebrae.
Additional file 1 of Brain activity and upper limb movement analysis in children with Down syndrome undergoing transcranial direct current stimulation combined with virtual reality training: study protocol for a randomized controlled trial
Creators: name: Lopes, Jamile Benite Palma
name: Miziara, Isabela Marques
name: Kahani, Danial
name: Parreira, Rodolfo Borges
name: de Almeida Carvalho Duarte, Natalia
name: Lazzari, Roberta Delasta
name: Santos, Lucas Villalta
name: de Mello Monteiro, Carlos Bandeira
name: da Silva Cardoso, Deborah Carvalho
name: de Oliveira Hassel Mendes, Juliana
name: dos Santos Alves, Vera Lucia
name: Silva, Iransé Oliveira
name: Oliveira, Luis Vicente
name: Conway, Bernard Arthur
name: Galli, Manuela
name: Cimolin, Veronica
name: Oliveira, Claudia Santos
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.
title: Diagnostik und Therapie der Osteomyelitis
Creators: name: Zagrodnick, Joachim
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Die Osteomyelitis ist eine seit langem bekannte Knocheninfektion. Ihre Behandlung stellt jeden Arzt wegen der mit der demografischen Entwicklung zunehmenden Polymorbidität unserer Patienten und zunehmenden Resistenzentwicklungen gegen Antibiotika vor große Herausforderungen.    Ziel der Behandlung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Spectral Evolution of the Unusual Slow Nova V5558 Sgr
Creators: name: Tanaka, Jumpei
name: Nogami, Daisaku
name: Fujii, Mitsugu
name: Ayani, Kazuya
name: Kato, Taichi
name: Maehara, Hiroyuki
name: Kiyota, Seiichiro
name: Nakajima, Kazuhiro
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report on the spectral evolution of the enigmatic, very slow nova V5558 Sgr, based on the low-resolution spectra obtained at the Fujii-Bisei Observatory and the Bisei Astronomical Observatory, Japan during a period of 2007 April 6 to 2008 May 3. V5558 Sgr shows a pre-maximum halt and then several flare-like rebrightenings, which is similar to another very slow nova V723 Cas. In our observations, the spectral type of V5558 Sgr evolved from the He/N type toward the Fe II type during the pre-maximum halt, and then toward the He/N type again. This course of spectral transition was observed for the first time in the long history of the nova research. In the rebrightening stage after the initial brightness maximum, we could identify many emission lines accompanied by a stronger absorption component of the P-Cygni profile at the brightness maxima. We found that the velocity of the P-Cygni absorption component measured from the emission peak decreased at the brightness maxima. Furthermore, we compared the spectra of V5558 Sgr with V723 Cas, and other novae which exhibited several rebrightenings during the early phase.
description: 8 pages, 7figures, accepted for publication in PASJ
Spin effects in the phasing of gravitational waves from binaries on eccentric orbits
Creators: name: Klein, Antoine
name: Jetzer, Philippe
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We compute here the spin-orbit and spin-spin couplings needed for an accurate computation of the phasing of gravitational waves emitted by comparable-mass binaries on eccentric orbits at the second post-Newtonian (PN) order. We use a quasi-Keplerian parametrization of the orbit free of divergencies in the zero eccentricity limit. We find that spin-spin couplings induce a residual eccentricity for coalescing binaries at 2PN, of the order of $10^{-4}$-$10^{-3}$ for supermassive black hole binaries in the LISA band. Spin-orbit precession also induces a non-trivial pattern in the evolution of the eccentricity, which could help to reduce the errors on the determination of the eccentricity and spins in a gravitational wave measurement.
description: 7 pages, 1 figure; Accepted for publication in Phys. Rev. D
Expression of tumor necrosis factor alpha and its receptors during cellular differentiation
Creators: name: Schling, Petra
name: Rudolph, Christian
name: Heimerl, Susanne
name: Fruth, Sabine
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Adipocyte; Chondrocyte; Epithelial cell; Osteocyte; Peripheral blood monocyte
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Tumor necrosis factor alpha (TNFalpha) is a potent proinflammatory cytokine also involved in cellular differentiation processes. TNFalpha and both of its receptors (TNFR1 and TNFR2) can be co-expressed on the same cell, allowing for local signaling. This study has examined the expression of all components necessary for autocrine cytokine regulation during human hematopoietic, epithelial, and mesenchymal models of cellular differentiation. Macrophage and dendritic differentiation of human peripheral blood monocytes decreased their TNFalpha and TNFR2 expression while increasing the TNFR1 mRNA. In colon epithelial cell lines (HT-29 and Caco-2) TNFalpha-, TNFR1-, and TNFR2-expression was decreased upon differentiation. No changes, however, were seen during human skin keratinocyte differentiation. TNFR1 expression was unchanged in all three mesenchymal lineages (adipogenesis, chondrogenesis, osteogenesis) tested. Differentiation decreases the TNFalpha message in adipocytes and the TNFR2 mRNA in adipocytes and osteocytes. Our results demonstrate that there is no general principle for TNFalpha signaling during conversion of cells from progenitor to a more differentiated phenotype. Paracrine signaling by TNFalpha to orchestrate different cell types during tissue development and remodeling, therefore, probably overrides the autocrine regulation of differentiation by TNFalpha. Non-signaling TNF-receptors may protect chondrocytes and osteocytes from the anti-differentiation effects of local TNFalpha production.
title: Leitlinie zur Behandlung der Hidradenitis suppurativa/Acne inversa
Creators: name: Zouboulis, Christos C.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Nach einer früheren empirischen Analyse traditioneller konservativer Behandlungsmaßnahmen zur Therapie der Hidradenitis suppurativa/Acne inversa (HS) erreichten nur ein 1-prozentiges Clindamycingel, die orale systemische Kombination von Clindamycin und Rifampicin und eine hormonelle Antiandrogenkombination[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Metastasis of a malignant melanoma 2 years after carbon dioxide laser treatment of a pigmented lesion: case report and review of the literature
Creators: name: Gottschaller, Christina
name: Hohenleutner, Ulrich
name: Landthaler, Michael
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: A 64-year-old woman with a clinically diagnosed 'lentigo simplex' on her right cheek was dermatologically treated several times with a CO2 laser. Three years later she showed a metastasis of a malignant melanoma in her right parotid gland. Considering this case, as well as other published cases reporting malignant melanomas occurring after laser treatment, we again underscore that naevomelanocytic lesions are not a routine indication for laser treatment.
title: Akademische Wund-Weiterbildung im Zertifikatsstudienlehrgang und Regelstudiengang Physician Assistant an der HS Anhalt
Creators: name: Karbe, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: In den USA stellen die Tätigkeitsmerkmale des Physician Assistants (PA) einen wichtigen Stellenwert innerhalb des amerikanischen Gesundheitssystems bereits seit den frühen 60er Jahren dar. Historisch entstand diese „Profession“ bereits während des II. Weltkrieges aus Mangel[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
title: Kooperation und Konkurrenz von biochemischen, zellulären und mikrobiellen Komponenten in chronischen Wunden
Creators: name: Wiegand, Cornelia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Chronische Wunden haben eine herausragende medizinische, soziale und gesundheitsökonomische Bedeutung, da sie zu einer langdauernden Einschränkung der Lebensqualität des Betroffenen führen. Zu den häufigsten Ursachen chronischer Wunden gehören das Ulcus cruris venosum (57%),[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Vacancy decay in endohedral atoms: the role of non-central position of the atom
Creators: name: Korol, Andrey V.
name: Solov'yov, Andrey V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate that the Auger decay rate in an endohedral atom is very sensitive to the atom's location in the fullerene cage. Two additional decay channels appear in an endohedral system: (a) the channel due to the change in the electric field at the atom caused by dynamic polarization of the fullerene electron shell by the Coulomb field of the vacancy, (b) the channel within which the released energy is transferred to the fullerene electron via the Coulomb interaction. % The relative magnitudes of the correction terms are dependent not only on the position of the doped atom but also on the transition energy $\om$. Additional enhancement of the decay rate appears for transitions whose energies are in the vicinity of the fullerene surface plasmons energies of high multipolarity. % It is demonstrated that in many cases the additional channels can dominate over the direct Auger decay resulting in pronounced broadening of the atomic emission lines. % The case study, carried out for Sc$^{2+}$@C$_{80}^{6-}$, shows that narrow autoionizing resonances in an isolated Sc$^{2+}$ within the range $\om = 30... 45$ eV are dramatically broadened if the ion is located strongly off-the-center. % Using the developed model we carry out quantitative analysis of the photoionization spectrum for the endohedral complex Sc$_3$N@C$_{80}$ and demonstrate that the additional channels are partly responsible for the strong modification of the photoionization spectrum profile detected experimentally by Müller et al. (J. Phys.: Conf. Ser. 88, 012038 (2008)).
description: 32 pages, 11 figures
title: Konsensus der Fachgremien zu den mikrobiologischen Untersuchungen bei Wundinfektionen
Creators: name: Papke, Roald
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Voraussetzung für die Entscheidung für eine mikrobiologische Wunddiagnostik sind der Verdacht oder die klinische Diagnose einer Wundinfektion. Dafür werden valide klinische Kriterien der Wundinfektion ohne und mit systemischer Beteiligung einschließlich laborchemischer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Decrease of thalamic gray matter following limb amputation
Creators: name: Draganski, B.
name: Moser, T.
name: Lummel, N.
name: Gänssbauer, S.
name: Bogdahn, U.
name: Haas, F.
name: May, A.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Neuroplasticity; Thalamus; SMA; Limb amputation; Cortex; Voxel-based morphometry; Phantom pain
subject: 610 Medizin

description: Modern neuroscience has elucidated general mechanisms underlying the functional plasticity of the adult mammalian brain after limb deafferentation. However, little is known about possible structural alterations following amputation and chronic loss of afferent input in humans. Using voxel-based morphometry (VBM), based on high-resolution magnetic resonance images, we investigated the brain structure of 28 volunteers with unilateral limb amputation and compared them to healthy controls. Subjects with limb amputation exhibited a decrease in gray matter of the posterolateral thalamus contralateral to the side of the amputation. The thalamic gray matter differences were positively correlated with the time span after the amputation but not with the frequency or magnitude of coexisting phantom pain. Phantom limb pain was unrelated to thalamic structural variations, but was positively correlated to a decrease in brain areas related to the processing of pain. No gray matter increase was detected. The unilateral thalamic differences may reflect a structural correlate of the loss of afferent input as a secondary change following deafferentation.
Tertium datur : making contact in Don DeLillo's Ratner's Star
Creators: name: Streit, Michael
Publisher: name: University of British Columbia
Year: 2018

description: Ratner’s Star is considered one of Don DeLillo’s more inaccessible texts, and with good reason: taking the history of mathematical progress as its major temporal arc, Ratner’s Star eschews many conventions of fiction in order to create a unique system that operates—as many critics have noted—on a complex interplay of opposites. Fewer critics, however, have noted the importance of genre to this text. Going beyond the customary nod to Menippean satire, critics David Cowart, John Johnston and Mark Osteen, in particular, investigate the history of this genre to pose texts such as Gulliver’s Travels and Alice in Wonderland as important models for Ratner’s Star. Extending existent scholarship, this present study roots DeLillo’s text firmly within the tradition of Menippean satire as defined by M. M. Bakhtin, not only to situate DeLillo’s concerns within the context of satire (this has already been accomplished) but also to activate a full-scale analysis of Ratner’s Star in Bakhtinian terminology. With Raphael’s School of Athens as a visual touchstone, this study investigates how DeLillo frames and re-frames the tension between the mathematically abstract and the materially tangible by employing Bakhtin’s definitions of the grotesque and heteroglossia. As a strongly grotesque character, Robert Hopper Softly and the “antrum” of his creation encapsulate such interplay of the abstract and the tangible while leaving this tension ambivalent and unresolved. The “New York episodes,” brief flashbacks where DeLillo grounds his protagonist in prosaic life, present a world according to the Menippean style of carnivalesque “slum naturalism,” wherein languages live and are lived in, rooted to their surroundings. On the other hand, Logicon, an artificial “universal” language, opposes the lived experience and heteroglossia of these New York episodes. In order to demonstrate DeLillo's suspicion of the destructive capability of such a universal language, this study concludes by defining Logicon as the primary antagonist of the novel, a tyrannical and abstracting force that threatens heteroglossic language and the plural realities it represents, Menippean satire as a genre embracing relativity, and most crucially, the artistic discourse of the novel itself.
Second-order post-Hartree-Fock perturbation theory for the electron current
Creators: name: Dzhioev, Alan A.
name: Kosov, D. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Based on the super-fermion representation of quantum kinetic equations we develop nonequilibrium, post-Hartree-Fock many-body perturbation theory for the current through a region of interacting electrons. We apply the theory to out of equilibrium Anderson model and discuss practical implementation of the approach. Our calculations show that nonequilibrium electronic correlations may produce significant quantitative and qualitative corrections to mean-field electronic transport properties. We find that the nonequilibrium leads to enhancement of electronic correlations.
Additional file 2 of Brain activity and upper limb movement analysis in children with Down syndrome undergoing transcranial direct current stimulation combined with virtual reality training: study protocol for a randomized controlled trial
Creators: name: Lopes, Jamile Benite Palma
name: Miziara, Isabela Marques
name: Kahani, Danial
name: Parreira, Rodolfo Borges
name: de Almeida Carvalho Duarte, Natalia
name: Lazzari, Roberta Delasta
name: Santos, Lucas Villalta
name: de Mello Monteiro, Carlos Bandeira
name: da Silva Cardoso, Deborah Carvalho
name: de Oliveira Hassel Mendes, Juliana
name: dos Santos Alves, Vera Lucia
name: Silva, Iransé Oliveira
name: Oliveira, Luis Vicente
name: Conway, Bernard Arthur
name: Galli, Manuela
name: Cimolin, Veronica
name: Oliveira, Claudia Santos
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2. Appendix A: Consent form for participation in clinical research.
Condon Domain Phase Diagram and Hysteresis Size for Beryllium
Creators: name: Kramer, R. B. G.
name: Egorov, V. S.
name: Jansen, A. G. M.
name: Joss, W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The Condon domain phase diagram for beryllium is determined in magnetic fields up to 10 T and at temperatures down to 1.3 K using a standard ac pick-up coil method to measure the de Haas-van Alphen (dHvA) effect. The detection of the transition point from the homogeneous state to the Condon domain state (CDS) is based on the extremely non-linear response to the modulation field resulting from a small irreversibility in the dHvA magnetization. The experimental results are compared with theoretical predictions calculated from the Fermi surface (FS) of beryllium. The width h_m of the hysteresis loop in the CDS is measured in a wide temperature and field region. A model for the hysteresis size is proposed and numerically calculated for the whole phase diagram.
Non-canonical roles of Bcl-xL in regulating mitochondrial function and morphology in pancreatic beta-cells
Creators: name: Shi, Rocky Qiushi
Publisher: name: University of British Columbia
Year: 2018

description: Glucose-stimulated insulin secretion from pancreatic β-cells depends on mitochondrial oxidative metabolism. Mitochondrial dysfunction is believed to be a significant factor in the development of type 2 diabetes (T2D). Mitochondria exist as dynamic networks and the control of mitochondrial biomass and fusion/fission dynamics is essential for cellular health and function. The anti-apoptotic protein Bcl-xL has recently been demonstrated to dampen β-cell mitochondrial metabolism and studies in other cell types suggest Bcl-xL regulates mitochondrial biomass and dynamics. We hypothesize that Bcl-xL is important for β-cell adaptation to metabolic stress by regulating mitochondrial dynamics and mass. To quantitatively study mitochondrial structural changes, we developed an image analysis pipeline for 2D/3D confocal imaging of mitochondria in FIJI. We applied the pipeline to primary islet cells and found that glucose stimulation is correlated with a more fragmented mitochondrial morphology. In vitro Bcl-xL overexpression causes β-cell mitochondria to lose their tubular network structure and aggregate. These changes to network morphology and kinetics are associated with decreased total mitochondrial volume and a marked impairment of β-cell O2 consumption. β-cell specific Bcl-xL knockout islet cells demonstrated increased basal activity and decreased average mitochondrion size, suggesting that they behave more similarly to β-cells undergoing glucose stimulation. Challenging β-cells with prolonged high glucose culture increased the size and overall connectivity of their mitochondrial network. In Bcl-xL knockout β-cells this increase in total mitochondrial mass and networking was significantly amplified, but was associated with reduced morphological and functional glucose-responsiveness of the individual mitochondrion. In conclusion, our in vitro data demonstrate that Bcl-xL affects mitochondrial networking, function, and adaptation to stress in pancreatic β-cells.
Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro
Creators: name: Kunz-Schughart, Leoni A.
name: Schroeder, Josef A.
name: Wondrak, Marit
name: Rey, Frank van
name: Lehle, Karla
name: Hofstaedter, Ferdinand
name: Wheatley, Denys N.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: endothelium; angiogenesis; human umbilical vein endothelial cell; multicellular spheroid; coculture; tubular structures
subject: 610 Medizin

description: The development of vessel-like structures in vitro to mimic as well as to realize the possibility of tissue-engineered small vascular networks presents a major challenge to cell biologists and biotechnologists. We aimed to establish a three-dimensional (3-D) culture system with an endothelial network that does not require artificial substrates or ECM compounds. By using human skin fibroblasts and endothelial cells (ECs) from the human umbilical vein (HUVECs) in diverse spheroid coculture strategies, we verified that fibroblast support and modulate EC migration, viability, and network formation in a 3-D tissue-like stromal environment. In mixed spheroid cultures consisting of human ECs and fibroblasts, a complex 3-D network with EC tubular structures, lumen formation, pinocytotic activity, and tight junction complexes has been identified on the basis of immunohistochemical and transmission electron microscopic imaging. Tubular networks with extensions up to 400 mum were achieved. When EC suspensions were used, EC migration and network formation were critically affected by the status of the fibroblast. However, the absence of EC migration into the center of 14-day, but not 3-day, precultured fibroblast spheroids could not be attributed to loss of F viability. In parallel, it was also confirmed that migrated ECs that entered cluster-like formations became apoptotic, whereas the majority of those forming vessel-like structures remained viable for >8 days. Our protocols allow us to study the nature of tubule formation in a manner more closely related to the in vivo situation as well as to understand the basis for the integration of capillary networks in tissue grafts and develop methods of quantifying the amount of angiogenesis in spheroids using fibroblast and other cells isolated from the same patient, along with ECs.
Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy
Creators: name: Dittmar, Michael S.
name: Vatankhah, Bijan
name: Fehm, Nando P.
name: Schuierer, Gerhard
name: Bogdahn, Ulrich
name: Horn, Markus
name: Schlachetzki, Felix
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Cerebral ischemia; Focal; Disease models; Animal; Rats; Middle cerebral artery occlusion; Carotid artery; Internal
subject: 610 Medizin

description: Middle cerebral artery occlusion (MCAO) in Fischer-344 rats results in a small variance of infarct size. However, complications are frequent especially in aged Fisher-344 rats undergoing endovascular suture occlusion of the middle cerebral artery. Analyzing our experiences with 165 Wistar, 13 Sprague-Dawley and 10 F-344 rats, we compared the incidence of impossible thread advancement and subarachnoid hemorrhage, respectively. Magnetic resonance angiography (MRA) was applied to study the course of the internal carotid artery (ICA) in Fischer and Wistar rats. Finally, we performed a structured review of the literature from 1991 to 2005 evaluating reports on Fischer rats subjected to intraluminal filament MCAO. Complications like fruitless filament advancement or subarachnoid hemorrhage were found to be significantly more frequent in Fischer rats than in other strains. MRA revealed significantly more pronounced kinking of the ICA in F-344 than in Wistar rats. In seven publications available on filament MCAO in F-344 rats, complication rates of 50-100% were reported, corroborating our data. Surgical difficulties accompanied by high complication rates due to their cerebrovascular anatomy make Fischer rats unsuitable for filament MCAO. If the use of Fischer rats for studies on focal cerebral ischemia is indicated, other ischemia models than intraluminal suture occlusion should be chosen.
A new pumpless extracorporeal interventional lung assist in critical hypoxemia/hypercapnia
Creators: name: Bein, Thomas
name: Weber, Frank
name: Philipp, Alois
name: Prasser, Christopher
name: Pfeifer, Michael
name: Schmid, Franz-Xaver
name: Butz, Bernhard
name: Birnbaum, Dietrich
name: Taeger, Kai
name: Schlitt, Hans J.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: OBJECTIVE: Pump-driven extracorporeal gas exchange systems have been advocated in patients suffering from severe acute respiratory distress syndrome who are at risk for life-threatening hypoxemia and/or hypercapnia. This requires extended technical and staff support. DESIGN: We report retrospectively our experience with a new pumpless extracorporeal interventional lung assist (iLA) establishing an arteriovenous shunt as the driving pressure. SETTING: University hospital. PATIENTS: Ninety patients with acute respiratory distress syndrome. INTERVENTIONS: Interventional lung assist was inserted in 90 patients with acute respiratory distress syndrome. MEASUREMENTS AND MAIN RESULTS: Oxygenation improvement, carbon dioxide elimination, hemodynamic variables, and the amount of vasopressor substitution were reported before, 2 hrs after, and 24 hrs after implementation of the system. Interventional lung assist led to an acute and moderate increase in arterial oxygenation (Pao2/Fio2 ratio 2 hrs after initiation of iLA [median and interquartile range], 82 mm Hg [64-103]) compared with pre-iLA (58 mm Hg [47-78], p < .05). Oxygenation continued to improve for 24 hrs after implementation (101 mm Hg [74-142], p < .05). Hypercapnia was promptly and markedly reversed by iLA within 2 hrs (Paco2, 36 mm Hg [30-44]) in comparison with before (60 mm Hg [48-80], p < .05], which allowed a less aggressive ventilation. For hemodynamic stability, all patients received continuous norepinephrine infusion. The incidence of complications was 24.4%, mostly due to ischemia in a lower limb. Thirty-seven of 90 patients survived, creating a lower mortality rate than expected from the Sequential Organ Failure Assessment score. CONCLUSIONS: Interventional lung assist might provide a sufficient rescue measure with easy handling properties and low cost in patients with severe acute respiratory distress syndrome and persistent hypoxia/hypercapnia.
title: Evidenz der Antiseptik
Creators: name: Daeschlein, Georg
name: Temboulatow, M.
name: Jünger, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Chronische Ulcuswunden, zunehmend älterer Patienten, stellen eine ständig wachsende Herausforderung der Wundversorgung in Praxis und Klinik dar. Welche Behandlungsform auch gewählt wird, in jedem Fall kommt es für die Patientensicherheit bezüglich Infektionsverhütung wie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Observations and properties of candidate high frequency GPS radio sources in the AT20G survey
Creators: name: Hancock, Paul J.
name: Sadler, Elaine M.
name: Mahony, Elizabeth K.
name: Ricci, Roberto
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We used the Australia Telescope Compact Array (ATCA) to obtain 40 GHz and 95 GHz observations of a number of sources that were selected from the Australia Telescope Compact Array 20 GHz (AT20G) survey . The aim of the observations was to improve the spectral coverage for sources with spectral peaks near 20 GHz or inverted (rising) radio spectra between 8.6 GHz and 20 GHz. We present the radio observations of a sample of 21 such sources along with optical spectra taken from the ANU Siding Spring Observatory 2.3m telescope and the ESO-New Technology Telescope (NTT). We find that as a group the sources show the same level of variability as typical GPS sources, and that of the 21 candidate GPS sources roughly 60% appear to be genuinely young radio galaxies. Three of the 21 sources studied show evidence of being restarted radio galaxies. If these numbers are indicative of the larger population of AT20G radio sources then as many as 400 genuine GPS sources could be contained within the AT20G with up to 25% of them being restarted radio galaxies.
description: 21 pages, 24 figures, Table 1 truncated at 11 columns
Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor
Creators: name: Gamulescu, Maria-Andreea
name: Chen, Youxin
name: He, Shikun
name: Spee, Christine
name: Jin, Manlin
name: Ryan, Stephen J.
name: Hinton, David R.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: mesenchymal transdifferentiation; transforming growth factor; hepatocyte growth factor; extracellular matrix; fibronectin; alpha-smooth muscle actin
subject: 610 Medizin

description: Retinal pigment epithelial (RPE) cells possess the potential to transdifferentiate into myofibroblasts after stimulation with transforming growth factor beta (TGFbeta) and are implicated in the pathogenesis of proliferative vitreoretinopathy. In this study we evaluated how TGFbeta2 and various extracellular matrix (ECM) proteins modulate the transdifferentiation of human fetal retinal pigment epithelial cells (RPE) cells into myofibroblast-like cells. Furthermore, we investigated whether hepatocyte growth factor (HGF) can suppress this transdifferentiation. RPE cells were cultured on ECM coated or uncoated surfaces in the presence or absence of TGFbeta2. HGF was added to certain cultures only once or on a daily basis during the treatment. Transdifferentiation of RPE cells into myofibroblasts was assessed by the quantitation of alpha-smooth muscle actin (alpha-SMA) using immunocytochemistry, flow cytometry, real-time PCR and Western blotting. TGFbeta2 induced a significant increase of alpha-SMA expression in a dose-dependent manner. Compared with growth on uncoated surfaces, RPE cultured on fibronectin (FN)-coated surfaces and stimulated with TGFbeta2 showed a significantly higher alpha-SMA expression than untreated cells. This upregulation of alpha-SMA could be markedly reduced by daily treatment with HGF; however, a single HGF administration did not significantly reduce alpha-SMA. These findings are important for further understanding the interaction of cytokines, RPE cells and their environment in mesenchymal transformation as well as its possible modulation. Continuous or long-term treatment with HGF should be further investigated for its potential to prevent mesenchymal transdifferentiation of RPE cells, and ultimately, PVR in vivo.
Qualitative and Quantitative Assessment of Hydrocarbons in Soil Profiles of Auto-Mechanic Workshop: A Case Study of Akure City, Nigeria
Creators: name: Adenike Bosede Alabi
name: Ademola Festus Aiyesanmi
name: Ololade, Isaac Ayodele
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology

description: The total petroleum hydrocarbons (TPH) and polycyclic aromatic hydrocarbon (PAH) contents of soils collected at various depths (0–15 cm, 15–30 cm, and 30–45 cm) within automobile repair workshops in Akure metropolis, Nigeria were qualitatively and quantitatively assessed using gas chromatographic-mass spectrometer (GC-MS). Long chain n-alkanes (n C8–C32) were detected across all soils. TPH concentration (in mg/kg) for the top soils ranged from 85.42 ± 3.42 to123.76 ± 4.37. The middle had a concentration range of 63.45 ± 3.47–90. 80 ± 3.97 and a range of 12.59 ± 3.34–72.97 ± 3.97 recorded for the 30–45 cm depths measured. Similarly, the mean total PAHs concentrations in top, middle and bottom soils ranged from 0.14 to 0.21 mg/kg, 0.11 to 0.17 mg/kg, and <0.01 to 0.11 mg/kg respectively. Positive correlation in TPAH and particle sizes and organic carbon was recorded (R2 > 0.890). Partitioning of the more hydrophobic high molecular weight (HMW)-PAHs occurs to a greater extent (72–93%) compared with low molecular weight (LMW)-PAHs. The overall results showed that the soils of the area were highly contaminated and might be detrimental to living existence, through contamination of ground and surface water.
The exponential sum over squarefree integers
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11L07

description: We give an upper bound for the exponential sum over squarefree integers. This establishes a conjecture by Brüdern and Perelli.
Additional file 3 of Brain activity and upper limb movement analysis in children with Down syndrome undergoing transcranial direct current stimulation combined with virtual reality training: study protocol for a randomized controlled trial
Creators: name: Lopes, Jamile Benite Palma
name: Miziara, Isabela Marques
name: Kahani, Danial
name: Parreira, Rodolfo Borges
name: de Almeida Carvalho Duarte, Natalia
name: Lazzari, Roberta Delasta
name: Santos, Lucas Villalta
name: de Mello Monteiro, Carlos Bandeira
name: da Silva Cardoso, Deborah Carvalho
name: de Oliveira Hassel Mendes, Juliana
name: dos Santos Alves, Vera Lucia
name: Silva, Iransé Oliveira
name: Oliveira, Luis Vicente
name: Conway, Bernard Arthur
name: Galli, Manuela
name: Cimolin, Veronica
name: Oliveira, Claudia Santos
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 3. Appendix B: Minor consent form.
Synthesis, Kinetics and a Full Mechanistic Investigation of Four-Component Reaction for Preparation of 2-Amino-3-Cyanopyridine Derivatives in the Presence of Green Catalysts
Creators: name: Sadegh Talaiefar
name: Sayyed Mostaf Habibi-Khorassani
name: Sharaki, Mehdi
name: Mollashahi, Ebrahim
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: 2-Amino-3-cyanopyridine derivatives have been synthesized via a four-component reaction of malononitrile (1), aromatic aldehyde (2), cyclohexanone (3), and amines (4) in the presence of fructose and maltose catalysts with good to excellent yields. In addition, for the first time we describe the experimental kinetics study and a full mechanistic investigation of title reaction. To determine the right position of each component in the reaction path, kinetic study of the reaction was carried out using UV–vis spectrophotometry technique. Based on temperature effects on the reaction rate, activation energy (Ea= 28.97 ± 0.21 kJ mol−1) and its parameters (ΔH‡ = 26.49 ± 0.23 kJ mol−1, ΔS‡ = −122.88 ± 0.67 J mol−1 K−1 and ΔG‡ = 63.12 ± 0.46 kJ mol−1) were determined, so the reaction was enthalpy and chemically controlled and also its mechanism was associative. By the change in the solvent polarity, it was found that polar solvents increase the reaction rate and the mixture of water/ethanol (50/50) was the best choice. Changing the structure of aniline (4) and benzaldehyde (2) by the substituent groups exhibited that the reaction proceeds faster in a poor electronic ring, regarding benzaldehyde (2), which is the result of the electron-withdrawing groups and a rich electronic ring for aniline, which is because of the electron donating groups. Further investigations on the partial orders of reactants approved the independency of the rate law to the concentrations of components (3) and (4), so the reaction was second-order kinetics corresponding to compounds (1) and (2) with the right rate law = k7k2k112Catk−6. Step7 was recognized as the RDS.
Colorimetric Detection of Pollutant Trivalent Cations and HSO4− in Aqueous Media Using a New Schiff-base Probe: An Experimental and DFT Studies
Creators: name: Orojloo, Masoumeh
name: Saeid Amani
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In the present study, a novel colorimetric Schiff-base receptor 4-((2-nitrophenyl) diazenyl)-2-((3-methylpyridin-2-ylimino)methyl)phenol was successfully synthesized via the condensation reaction of an azo-coupled precursor to 2-amino-3-methylpyridine in absolute ethanol and a good yield. The probe provided the selective detection of trivalent Cr3+, Fe3+, and Al3+ cations with different color changes. The binding constants of complexation (ka), the molar absorption coefficient (ɛ), and the limit of detection parameters of trivalent ions were measured for Cr3+, Fe3+, and Al3+. The results revealed a high sensitivity for the selective detection of Fe3+ ions. Moreover, the devised receptor rapidly detected the HSO4− anion through absorption spectra and color changes. The HSO4− and Al3+ coordination properties were checked by the 1HNMR titration method. The sensing behavior of the L receptor was further emphasized in computational studies. Accordingly, quantum-chemical studies via Density Functional Theory (DFT) were carried out using the 6–31 + G (d) basis set of the Gaussian 03 program package in order to more supplement the detecting behavior of the L receptor in case of HSO4− anions. The HSO4− and Al3+ coordination properties were investigated by the 1HNMR titration.
Quasi-Two-Dimensional Fermi Surfaces and Coherent Interlayer Transport in KFe$_2$As$_2$
Creators: name: Kimata, M.
name: Terashima, T.
name: Kurita, N.
name: Satsukawa, H.
name: Harada, A.
name: Kodama, K.
name: Sato, A.
name: Imai, M.
name: Kihou, K.
name: Lee, C. H.
name: Kito, H.
name: Eisaki, H.
name: Iyo, A.
name: Saito, T.
name: Fukazawa, H.
name: Kohori, Y.
name: Harima, H.
name: Uji, S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report the results of the angular-dependent magnetoresistance oscillations (AMROs), which can determine the shape of bulk Fermi surfaces in quasi-two-dimensional (Q2D) systems, in a highly hole-doped Fe-based superconductor KFe$_2$As$_2$ with $T_c \approx$ 3.7 K. From the AMROs, we determined the two Q2D FSs with rounded-square cross sections, corresponding to 12% and 17% of the first Brillouin zone. The rounded-squared shape of the FS cross section is also confirmed by the analyses of the interlayer transport under in-plane fields. From the obtained FS shape, we infer the character of the 3d orbitals that contribute to the FSs.
description: 4 pages, 4 figures, accepted in Phys. Rev. Lett
Stone-Wales--type transformations in carbon nanostructures driven by electron irradiation
Creators: name: Kotakoski, J.
name: Meyer, J. C.
name: Kurasch, S.
name: Santos-Cottin, D.
name: Kaiser, U.
name: Krasheninnikov, A. V.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Observations of topological defects associated with Stone-Wales-type transformations (i.e., bond rotations) in high resolution transmission electron microscopy (HRTEM) images of carbon nanostructures are at odds with the equilibrium thermodynamics of these systems. Here, by combining aberration-corrected HRTEM experiments and atomistic simulations, we show that such defects can be formed by single electron impacts, and remarkably, at electron energies below the threshold for atomic displacements. We further study the mechanisms of irradiation-driven bond rotations, and explain why electron irradiation at moderate electron energies (\sim100 keV) tends to amorphize rather than perforate graphene. We also show via simulations that Stone-Wales defects can appear in curved graphitic structures due to incomplete recombination of irradiation-induced Frenkel defects, similar to formation of Wigner-type defects in silicon.
Induction of Raf kinase inhibitor protein contributes to macrophage differentiation
Creators: name: Schuierer, Marion M.
name: Heilmeier, Ursula
name: Boettcher, Alfred
name: Ugocsai, Peter
name: Bosserhoff, Anja K.
name: Schmitz, Gerd
name: Langmann, Thomas
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Gene expression; Raf kinase inhibitor protein; Macrophage differentiation; NFκB; Scavenger receptors; THP-1 cells
subject: 610 Medizin

description: Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation. Using realtime RT-PCR and Western blot analysis we were able to confirm the initial DNA-microarray findings of RKIP induction on mRNA and protein levels. RKIP upregulation in primary cells and overexpression in THP-1 cells did not alter ERK activity but strongly reduced the amount of the NFkappaB subunit p65 in the nucleus. mRNA levels and cell surface expression of maturation markers including the integrin CD11c and the scavenger receptor CD36 were significantly increased in RKIP transfected THP-1 cells. Our data show for the first time that RKIP is upregulated during macrophage and dendritic cell differentiation on mRNA and protein levels and we conclude that RKIP contributes to the monocytic differentiation process via inhibition of the NFkappaB signaling cascade independent from the canonical Ras/Raf/MEK/ERK pathway.
Perturbative improvement of SU(2) gauge theory with two Wilson fermions in the adjoint representation
Creators: name: Karavirta, Tuomas
name: Mykkanen, Anne-Mari
name: Rantaharju, Jarno
name: Rummukainen, Kari
name: Tuominen, Kimmo
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present a perturbative calculation of the improvement coefficients of SU(2) gauge theory with adjoint representation Wilson-clover fermions and using Schrodinger functional boundary conditions. The computation of the boundary improvement terms is necessary for the full O(a) improvement. With two flavours of adjoint representation fermions this theory is called Minimal Walking Technicolor model.
description: Contribution for the Proceedings of the XXVIII International Symposium on Lattice Field Theory, Lattice2010