cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
NON-OVERLAPPING DOMAIN DECOMPOSITION METHODS FOR CARDIAC REACTION-DIFFUSION MODELS AND APPLICATIONS
Creators: name: ZAMPINI, STEFANO
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: In this thesis we consider different aspects related to the mathematical modeling of cardiac electrophysiology, either from the cellular or from the tissue perspective, and we develope novel numerical methods for the parallel iterative solution of the resulting reaction-diffusion models. In Chapter one we develope and validate the HHRd model, which accounts for transmural cellular heterogeneities of the canine left ventricle. Next, we introduce the reaction-diffusion models describing the spread of excitation in cardiac tissue, namely the anisotropic Bidomain and Monodomain models. For their discretization, we consider trilinear isoparametric finite elements in space and a semi-implicit (IMEX) method in time. In order to reduce the computational costs of parallel three-dimensional cardiac simulations, in Chapter three we consider different strategies to accelerate convergence of the Preconditioned Conjugate Gradient method. We consider novel choices for the Krylov initial guess in order to reduce the number of iterations per time step, either lagrangian interpolants in time or the Proper Orthogonal Decomposion technique combined with a usual Galerkin projection. In the last three chapters we construct non-overlapping domain decomposition methods for both cardiac reaction-diffusion models. In Chapter four we deal with preconditioners of the Neumann-Neumann type, in particular we consider the additive Neumann-Neumann method for the Monodomain model and the Balancing Neumann-Neumann method for the Bidomain model. In Chapter five we construct a Balancing Domain Decomposition by Constraint (BDDC) method for the Bidomain model, whereas in Chapter six we investigate the use of an approximate BDDC method for the Bidomain model. For all preconditioners considered, we develope novel theoretical estimates for the condition number of the preconditioned systems with respect to the spatial discretization, to the subdomains' diameter and to the time step, also in case of discontinuity in the conductivity coefficients of the cardiac tissue, with jumps aligned with the interface among subdomains. We prove scalability and quasi-optimality for the balancing methods, providing parallel numerical results confirming the theoretical estimates.
Brain Mechanisms of Emotions: An overview
Creators: name: Miladinovic, Aleksandar
Publisher: name: figshare
Year: 2020
Subjects: Neuroscience

description: Studying emotions and feelings can be extremely challenging job, especially consideringthat feeling include subjective component. In this regard affective neuroscience was borntrying to investigate neural basis of emotions, moods and feelings. This topic is especiallyinteresting for me since even though emotions and feeling sound self-explanatory, there isno single accepted definition of these terms. However, term emotions has root in term mo-tion (movement), including all sorts of movement (hormone release, muscular movementetc.) that can serve us as point of departure for further explanation.There is probably not a single system of emotion, for sure modern tools in neurosciencehelped us to identify brain regions that are involved in the processing of emotions, andthese are: (1) Hypothalamus, (2) Amygdala and (3) Parts of the cerebral cortex.
Constraining the galaxy mass content in the core of A383 using velocity dispersion measurements for individual cluster members
Creators: name: Monna, A.
name: Seitz, S.
name: Zitrin, A.
name: Geller, M. J.
name: Grillo, C.
name: Mercurio, A.
name: Greisel, N.
name: Halkola, A.
name: Suyu, S. H.
name: Postman, M.
name: Rosati, P.
name: Balestra, I.
name: Biviano, A.
name: Coe, D.
name: Fabricant, D. G.
name: Hwang, H. S.
name: Koekemoer, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use velocity dispersion measurements of 21 individual cluster members in the core of Abell 383, obtained with MMT Hectospec, to separate the galaxy and the smooth dark halo (DH) lensing contributions. While lensing usually constrains the overall, projected mass density, the innovative use of velocity dispersion measurements as a proxy for masses of individual cluster members breaks inherent degeneracies and allows us to (a) refine the constraints on single galaxy masses and on the galaxy mass-to-light scaling relation and, as a result, (b) refine the constraints on the DM-only map, a high-end goal of lens modelling. The knowledge of cluster member velocity dispersions improves the fit by 17% in terms of the image reproduction $χ^2$, or 20% in terms of the rms. The constraints on the mass parameters improve by ~10% for the DH, while for the galaxy component, they are refined correspondingly by ~50%, including the galaxy halo truncation radius. For an L$^*$ galaxy with M$^*_B$=-20.96, for example, we obtain best fitting truncation radius r$^*_{tr}=20.5^{+9.6}_{-6.7}$ kpc and velocity dispersion $σ^*=324\pm17 km/s$. Moreover, by performing the surface brightness reconstruction of the southern giant arc, we improve the constraints on r$_{tr}$ of two nearby cluster members, which have measured velocity dispersions, by more than ~30%. We estimate the stripped mass for these two galaxies, getting results that are consistent with numerical simulations. In the future, we plan to apply this analysis to other galaxy clusters for which velocity dispersions of member galaxies are available.
description: 19 pages, 14 figures, 5 tables; submitted to MNRAS on 29 Oct. 2014, Accepted for publication on 28 Nov. 2014
OBJECTS OF CIVIL LAW RELATIONS
Creators: name: Kostruba, Anatoliy
Publisher: name: Zenodo
Year: 2020
Subjects: civi law
legal fact
civil legal relations
content of legal relations
OBJECTS OF CIVIL LAW RELATIONS
OBJECTS OF LAW

description: The existence of civil law relations is associated with a certain good, which is of a corresponding interest for their participants. The good is an object and means of meeting the needs of a person. Efforts to obtain such goods are the basis for the formation of civil relations by their participants. In civil law, such a good is called the object of civil law relations. Such objects are possessions, including money and securities, other property, property rights, deliverables, services, intellectual and creative deliverables, information, as well as other tangible and intangible good, objects of human and animal physiology. Objects of civil law relations may be freely alienated or transferred from one person to another by way of succession or inheritance, unless they are withdrawn from civil circulation, limited in circulation or inseparable from an individual or legal entity. Thus, the signs of the objects of civil law relations are the following: Value - is the property of an object or phenomenon to meet the needs, wishes, interests of a social subject (individual, group of people in society) Circulability - is the property of free alienation in favor of others.
description: https://youtu.be/5Bm9lAgSmkg https://youtu.be/c7k3MpKM3tc
description: {"references": ["https://youtu.be/c7k3MpKM3tc", "https://youtu.be/5Bm9lAgSmkg"]}
Sleep and Dreaming: An overview from the neuroscience perspective
Creators: name: Miladinovic, Aleksandar
Publisher: name: figshare
Year: 2020
Subjects: Neuroscience
Neuroscience and Physiological Psychology

description: For many centuries, scholars are trying to make sense and to understand what consciousness is. As a cognitive science student, I am interested in a scientific approach to studyinghuman mind, where sleeping and dreaming have important functions in general. One of thesimplest philosophical definitions of consciences is “Consciousness is that thing you got fromthe time you wake up in the morning until the time you go to sleep at night” - with the implication that during our sleeping we are not consciousness. Thing about this problem manyinteresting questions arise, as a function of the sleeping and dreaming; what is the role ofsleep, learning and memory, etc. From practical aspect insomnia and other sleep disordersare major problems for healthcare. Sleep and dreams can also help us to address the aspectsof the mind-body problem, especially the problem of neural correlates of sleep, in sense thatif we lose consciousness when falling asleep, we are expecting to see some changes in neurophysiology in wake and sleep states.
Особенности продуктивности сахарной свёклы, повреждённой гербицидами – ингибиторами фермента ГФПД
Creators: name: Е.А. Дворянкин
Publisher: name: Сахар
Year: 2022
Subjects: сахарная свёкла
гербициды
фитотоксичность
факторы среды
продуктивность
sugar beet
herbicides
phytotoxicity
environment factors
productivity.

description: Проведены полевые испытания действия сублетальных и изреживающих посев доз гербицидов – ингибиторов фермента ГФПД на растения сахарной свёклы в зависимости от фазы развития культуры и погодных условий. Описаны характерные симптомы повреждения гербицидами сахарной свёклы на ранних стадиях развития. Гербициды «Каллисто» и «Мерлин» в малых дозах активно подавляли нарастание массы, изреживали посев, снижали продуктивные показатели сахарной свёклы. Показано, что примеси гербицидов –ингибиторов ГФПД в растворе БЭОФ, 1,3 л/га вызывали синергический эффект усиления негативного воздействия смеси гербицидов на растения сахарной свёклы.
description: Field trials testing effect of sublethal and reducing plant density doses of herbicides – inhibitors of GFPD enzyme on sugar beet plants depending on the crop development stage and weather conditions have been conducted. Characteristic symptoms of sugar beet damage by herbicides at early development stages are described. Herbicides «Kallisto» and «Merlin» in small doses actively inhibited mass increase, reduced plant density, and decreased sugar beet productivity indices. It has been shown that admixtures of herbicides – inhibitors of GFPD in solution of Betanal Expert OF (1.3 l/ha) cause a synergetic effect enhancing negative influence of the herbicides’ mixture on sugar beet plants.
Разработка гранулированных антиоксидантных продуктов на основе сахарозы
Creators: name: А.А. Славянский
name: Д.П. Митрошина
name: В.А. Грибкова
Publisher: name: Сахар
Year: 2022
Subjects: гранулирование
белый сахар
кристаллизация
гранулированный сахарсодержащий продукт
β-каротин
зелёный чай
granulation
white sugar
crystallization
granulated sugar product
β-carotene
green tea

description: Важнейшим направлением развития науки о питании является создание продуктов функционального назначения, имеющих в своём составе как основные нутриенты, так и микронутриенты, в частности витамины и антиоксиданты. Поскольку белый сахар относится к продуктам повседневного спроса и по своему химическому составу представляет собой чистейший дисахарид (сахароза), он является наиболее универсальным сырьём для производства новых видов функциональных продуктов. В ходе исследования была разработана технология производства гранулированного сахарсодержащего продукта, обогащённого веществами антиоксидантной направленности – β-каротином и экстрактом зелёного чая. Установлено, что полученный гранулированный сахарсодержащий продукт представляет собой перспективный источник антиоксидантов для производства пищевых продуктов.
description: The most important direction in the development of nutrition science is the creation of functional products, known in their composition as the main nutrients and micronutrients, in particular vitamins and antioxidants. White sugar is a product of everyday consumption and, according to its usual chemical composition, is a pure disaccharide (sucrose), that is, it is the most versatile raw material for the production of new types of functional products. In the course of the study, a technology was developed for the production of a granular sugar-containing product enhanced by the absorption of antioxidant cravings β-carotene and green tea extract. It has been established that the resulting granulated sugar-containing product is a promising source of antioxidants for food production.
Sleep and Dreaming : Introduction to Neuroscience
Creators: name: Miladinovic, Aleksandar
Publisher: name: figshare
Year: 2020
Subjects: Neuroscience
Neuroscience and Physiological Psychology

description: For many centuries, scholars are trying to make sense and to understand what consciousness is. As a cognitive science student, I am interested in a scientific approach to studyinghuman mind, where sleeping and dreaming have important functions in general. One of thesimplest philosophical definitions of consciences is “Consciousness is that thing you got fromthe time you wake up in the morning until the time you go to sleep at night” - with the implication that during our sleeping we are not consciousness. Thing about this problem manyinteresting questions arise, as a function of the sleeping and dreaming; what is the role ofsleep, learning and memory, etc. From practical aspect insomnia and other sleep disordersare major problems for healthcare. Sleep and dreams can also help us to address the aspectsof the mind-body problem, especially the problem of neural correlates of sleep, in sense thatif we lose consciousness when falling asleep, we are expecting to see some changes in neurophysiology in wake and sleep states.
Preguntas encuesta y entrevista ByD 2020
Creators: name: López-Borrull, Alexandre
name: Abadal, Ernest
name: Ollé, Candela
Publisher: name: figshare
Year: 2020
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Preguntas de las entrevistas y las encuestas
An atomic resolution, single-spin magnetic resonance detection concept based on tunneling force microscopy
Creators: name: Payne, A.
name: Ambal, K.
name: Boehme, C.
name: Williams, C. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A comprehensive study of a force detected single-spin magnetic resonance measurement concept with atomic spatial resolution is presented. The method is based upon electrostatic force detection of spin-selection rule controlled single-electron tunneling between two electrically isolated paramagnetic states. Single spin magnetic resonance detection is possible by measuring the force detected tunneling charge noise on and off spin resonance. Simulation results of this charge noise, based upon physical models of the tunneling and spin physics, are directly compared to measured AFM system noise. The results show that the approach could provide single spin measurement of electrically isolated qubit states with atomic spatial resolution at room temperature.
description: 26 pages, 8 figures
Совместная переработка сахарной свёклы и сахара-сырца
Creators: name: Ю.И. Зелепукин
name: С.Ю. Зелепукин
Publisher: name: Сахар
Year: 2022
Subjects: совместная переработка свёклы и сахара-сырца
хлорная известь
керамзитовый порошок
oint processing of beetroot and raw sugar
bleach
expanded clay powder

description: Свеклосахарные заводы должны иметь гибкую технологическую схему, которая предусматривала бы возможность совместной переработки сахарной свёклы и сахара-сырца. Целесообразность совместной переработки может возникнуть в любой момент, так как обстановка на мировом сахарном рынке постоянно меняется и вероятность поступления на отечественный рынок сахара-песка не исключена, а значит, свеклосахарные заводы должны быть мобильны к совместной переработке свёклы и сахара-сырца. Это позволит увеличить период активной работы на сахарных заводах, повысив тем самым рентабельность и технико-экономические показатели завода в целом.
description: Sugar beet factories should have a flexible technological scheme that would provide for the possibility of joint processing of sugar beet and raw sugar. The expediency of joint processing can arise at any time, because the situation on the world sugar market is constantly changing and the probability of entering the domestic market of granulated sugar is not excluded, which means sugar beet factories should be mobile to the joint processing of beet and raw sugar. This will increase the period of active work in sugar fields, thereby increasing the profitability and technical and economic indicators of the plant as a whole.
Polynomials on Parabolic Manifolds
Creators: name: Aytuna, Aydın
name: Sadullaev, Azimbay
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: Primary 32U05, 32U15, 46A61, Secondary 46A63

description: A Stein manifold X is called S-parabolic if it possesses a plurisub- harmonic exhaustion function p that is maximal outside a compact subset of X: In analogy with (Cn; ln jzj), one defines the space of polynomials on a S- parabolic manifold (X; p) as the set of all analytic functions with polynomial growth with respect to p. In this work, which is, in a sense continuation of [7], we will primarily study polynomials on S-parabolic Stein manifolds. In Section 2, we review different notions of paraboliticity for Stein manifolds, look at some examples and go over the connections between parabolicity of a Stein manifold X and certain linear topological properties of the Fréchet space of global analytic functions on X. In Section 4 we construct an example of a S-parabolic manifold, with no nontrivial polynomials. This example leads us to divide S-parabolic manifolds into two groups as the ones whose class of polynomials is dense in the corresponding space of analytic functions and the ones whose class of polynomials is not so rich. In this way we introduce a new notion of regularity for S-parabolic manifolds. In the final section we investigate linear topolog- ical properties of regular S-parabolic Stein manifolds and show in particular that the space of analytic functions on such manifolds have a basis consisting of polynomials. We also give a criterion for closed submanifolds of a regular S-parabolic to be regular S-parabolic, in terms of existence of tame extension operators for the spaces of analytic functions defined on these submanifolds.
description: 22 pages
Propagation Length of Self-healing Slip Pulses at the Onset of Sliding: A Toy Model
Creators: name: Braun, Oleg
name: Scheibert, J
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Macroscopic sliding between two solids is triggered by the propagation of a micro-slip front along the frictional interface. In certain conditions, sliding is preceded by the propagation of aborted fronts, spanning only part of the contact interface. The selection of the characteristic size spanned by those so-called precursors remains poorly understood. Here, we introduce a 1D toy model of precursors between a slider and a track in which the fronts are quasi-static self-healing slip pulses. When the slider's thickness is large compared to the elastic correlation length and when the interfacial stiffness is small compared with the bulk stiffness, we provide an analytical solution for the length of the first precursor, Λ, and the shear stress field associated with it. These quantities are given as a function of the bulk material parameters, the frictional properties of the interface and the macroscopic loading conditions. Analytical results are in quantitative agreement with the numerical solution of the model. In contrast with previous models, our model predicts that Λ does not depend on the frictional breaking threshold of the interface. Our results should be relevant to the various systems in which self-healing slip pulses have been observed.
description: 10 pages, 3 figures
Polarons in Ultracold Fermi Superfluids
Creators: name: Yi, Wei
name: Cui, Xiaoling
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study a new type of Fermi polaron induced by an impurity interacting with an ultracold Fermi superfluid. Due to the three-component nature of the system, the polaron can become trimer-like with a non-universal energy spectrum. We identify multiple avoided crossings between impurity- and trimer-like solutions in both the attractive and the repulsive polaron spectra. In particular, the widths of avoided crossings gradually increase as the Fermi superfluid undergoes a crossover from the BCS side towards the BEC side, which suggests instabilities towards three-body losses. Such losses can be reduced for interaction potentials with small effective ranges. We also demonstrate, using the second-order perturbation theory, that the mean-field evaluation of the fermion-impurity interaction energy is inadequate even for small fermion-impurity scattering lengths, due to the essential effects of Fermi superfluid and short-range physics in such a system. Our results are practically useful for cold atom experiments on mixtures.
description: 7 pages, 6 figures, updated with the published version
title: Analysis of Giovan Battista Bellaso’s Cipher Challenges of 1555
Creators: name: Biermann, Norbert
Publisher: name: Universität der Künste Berlin
Year: 2020

description: This is an Accepted Manuscript of an article published by Taylor & Francis in Cryptologia on 12 Feb 2018. Abstract: In his book ‘Noui et singolari modi di cifrare’, Giovan Battista Bellaso presents to his readers three challenge ciphertexts. Two of them are based on a polyalphabetic cipher with a mixed primary reciprocal alphabet and a long key, whereas the third one uses four independent homophonic substitution alphabets which change after each word. A successful approach to solving these ciphers, to which Bellaso gave the name ‘terzo modo’ and ‘quarto modo’, performs a simulated annealing attack directly on the primary alphabet respectively the four homophonic alphabets at once. This paper focusses on the various applied fitness functions. The solutions for the ciphertexts are given and finally discussed, with a view toward the possibility of a hidden message within the plaintexts.
Cell therapies in the clinic
Creators: name: Kumbhojkar, N.
name: Wang, L.L.-W.
name: Anselmo, A.C.
name: Mitragotri, S.
name: Heavey, M.K.
name: Janes, M.E.
name: Clegg, J.R.
name: Prakash, S.
name: Kapate, N.
name: Zhao, Z.
Publisher: name: Blackwell Publishing Ltd
Year: 2021

description: Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics. Particularly, living cells can simultaneously and dynamically perform complex biological functions in ways that conventional drugs cannot; cell therapies have expanded the spectrum of available therapeutic options to include key cellular functions and processes. As such, cell therapies are currently one of the most investigated therapeutic modalities in both preclinical and clinical settings, with many products having been approved and many more under active clinical investigation. Here, we highlight the diversity and key advantages of cell therapies and discuss their current clinical advances. In particular, we review 28 globally approved cell therapy products and their clinical use. We also analyze >1700 current active clinical trials of cell therapies, with an emphasis on discussing their therapeutic applications. Finally, we critically discuss the major biological, manufacturing, and regulatory challenges associated with the clinical translation of cell therapies.
Measurement of Angle Emissivity of Smoothness Materials using Thermographic Methods
Creators: name: E N, ganesh
Publisher: name: figshare
Year: 2022
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Various smoothnesses and types of materials are used in microelectronics. The body's own emissions are used to measure temperature using the distance method. This requires knowledge of the emissivity from different viewing angles. This paper presents the results of an experimental evaluation of the emissivity of various materials used in microelectronics and electronics
Diagnosing the burst influence upon accretion in the clocked burster GS 1826--238
Creators: name: Ji, Long
name: Zhang, Shu
name: Chen, YuPeng
name: Zhang, Shuang-Nan
name: Torres, Diego F.
name: Kretschmar, Peter
name: Kuulkers, Erik
name: Li, Jian
name: Chang, Zhi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Type-I X-ray bursts on the surface of a neutron star are a unique probe to the accretion in X-ray binary systems. However, we know little about the feedback of the burst emission upon accretion. Hard X-ray shortages and enhancements of the persistent emission at soft X-rays have been observed. To put these findings in context with the aim of understanding the possible mechanism underneath, we investigated 68 bursts seen by RXTE from the clocked burster GS 1826--238. We diagnosed jointly the burst influence at both soft and hard X-rays, and found that the observations can be described as the CompTT model with variable normalization, electron temperature and optical depth. Putting these results in a scenario of coronal Compton cooling via the burst emission would lead to a shortage of the cooling power, which may suggest that additional consideration like the influence of the burst on the corona formation should be accounted for as well.
description: 14 pages, 4 figures, accepted for publication in ApJ
NATURE DEL BENESSERE. GLI EFFETTI PSICOLOGICI DELL'AMBIENTE NATURALE IN UNA PROSPETTIVA BIO-CULTURALE.
Creators: name: RAINISIO, NICOLA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: The research in Environmental Psychology stated that visit or simply perceive natural landscapes is clearly linked with some positive psychological outcomes on stress, attention restoration, cognitive functioning. These effects have been poorly investigated in wider perspective, favouring a limited evolutionary orientation that attempting to establish universal processes. Our contribution criticizes this mainstream view, suggesting that the results of recent researches indicate the relevance of other factors: positive emotions, identification and place attachment, optimal experiences, social ties, cultural belonging. A new bio-cultural framework is proposed, linking these different factors in a systemic perspective, encompassing natural areas, evolutionary needs, positive place experiences and cultures. The model is tested by two studies. The first states the importance of attachment, familiarity and flow in influencing the preferences for different biomes and their perceived restorativeness. The second replicates the first introducing as a causal factor the cultural differences between two groups.
Batch Culture Formulation of Live Biotherapeutic Products
Creators: name: Anselmo, A.C.
name: Qiu, K.
Publisher: name: Blackwell Publishing Ltd
Year: 2021

description: Live biotherapeutic products (LBPs) are an emerging therapeutic modality that have been clinically investigated for treating pathogenic infections and inflammatory diseases. A major class of LBPs are feces-derived microbial consortiums which require numerous process development steps (e.g., separation, purification, blending) to facilitate LBP formulation into oral dosage forms. A subset of these LBPs circumvents the need for continuous fecal processing by batch culture for individual strains of microbes that are rationally defined and combined in the final LBP formulation. Separately, delivery formulations (e.g., polymer encapsulation) are being developed for LBPs to improve storage and intestinal engraftment; however, formulation requires additional manufacturing processes distinct from fecal processing or batch culture. Here, a streamlined approach termed batch culture formulation (BCF) is developed to combine the individual batch culture and formulation processes into a single-step process. Based on a previously described polymeric film formulation that encapsulates LBPs, BCF is shown to reduce the number of required processes to formulate LBP-films without altering LBP phenotype, function, or storage profiles compared to the standard LBP-film formulation approach. Additionally, it is demonstrated that BCF facilitates scaled-fabrication from the milligram to gram scale with predictable loading, highlighting the potential that BCF has for clinical translation.
The MaxEnt extension of a quantum Gibbs family, convex geometry and geodesics
Creators: name: Weis, Stephan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss methods to analyze a quantum Gibbs family in the ultra-cold regime where the norm closure of the Gibbs family fails due to discontinuities of the maximum-entropy inference. The current discussion of maximum-entropy inference and irreducible correlation in the area of quantum phase transitions is a major motivation for this research. We extend a representation of the irreducible correlation from finite temperatures to absolute zero.
description: 8 pages, 3 figures, 34th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering, 21-26 September 2014, Ch\^ateau du Clos Luc\'e, Amboise, France
MOLECULAR CHARACTERIZATION OF CLATHRIN-DEPENDENT EGFR ENDOCYTOSIS UNVEILS DISTINCT INTERNALIZATION MECHANISMS THAT COUPLE WITH DIFFERENT SIGNALING OUTPUTS
Creators: name: ALGISI, VERONICA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that induces cell differentiation, proliferation and migration upon ligand activation. EGFR endocytosis is critical for the regulation of its signalling. Despite the enormous amount of work on this topic, the endocytic mechanisms that regulate EGFR signalling have not been completely elucidated. The EGFR can be endocytosed through either clathrin-mediated endocytosis (CME) or non-clathrin endocytosis (NCE), depending on ligand concentration. NCE of the EGFR is mainly associated with receptor degradation; CME, on the other hand, primarily leads to EGFR recycling and sustained signaling, although a minority of receptors is also delivered to degradation through this pathway. Recent proteomic and imaging studies have revealed a complex molecular portrait of CME with more than 30 proteins involved in the assembly and maturation of clathrin-coated pits. The involvement of such a wealth of proteins in CME ? together with the large variety of endocytic sorting signals ? raises the possibility of the existence of distinct types of clathrin-coated pits, specialized in terms of cargo-selection and intracellular fate. To investigate this possibility, we carried out a complete characterization of ligand-induced EGFR internalization and signaling, upon RNA interference of different endocytic adaptor proteins. Molecular genetics and biochemical assays were employed in this study allowing a comprehensive analysis of EGFR endocytosis. Our results indicate the existence of specialized clathrin adaptors involved in EGFR internalization, namely eps15, eps15R and epsin1, which function in parallel with AP2, previously considered to be the exclusive clathrin adaptor. Importantly, our data show that this molecular heterogeneity of EGFR clathrin vesicles ultimately impacts on EGF-dependent signaling and biological response. On the mechanistic level, we found that monoubiquitination of these adaptors is absolutely required for AP2-independent EGFR internalization through CME. Importantly, this is the first demonstration of a positive role of monoubiquitination in early EGFR internalization events.
Study of Elevator system using Fault-Injection Tool
Creators: name: E N, ganesh
Publisher: name: figshare
Year: 2022
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This document describes the Fault Injection Environment (FIE) for the (DES) distributed elevator system. Presented. FIE is able to assess the correctness of the design and implementation of the hardware and software mechanisms present in embedded microprocessor-based systems and calculate the fault coverage they provide. This whitepaper describes and analyzes different solutions for implementing the most important modules. Powerful hardware fault emulation technology is also under development. Communication is a very important segment given that embedded systems are hierarchical. Safety-critical systems require fault-tolerant communication between components. This is especially important for distributed real-time systems based on communication results. Moreover, given that the FIE implementation is used in a distributed structure elevator processor, a large number of experimental runs can be performed in a relatively short time. On the other hand, many bugs have been introduced into the simulation model of the prototype implementation and the behavior of the system in the real environment has been observed.
Superradiant Quantum Heat Engine
Creators: name: Hardal, Ali Ü. C.
name: Müstecaplıoglu, Özgür E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum physics revolutionized classical disciplines of mechanics, statistical physics, and electrodynamics. One branch of scientific knowledge however seems untouched: thermodynamics. Major motivation behind thermodynamics is to develop efficient heat engines. Technology has a trend to miniaturize engines, reaching to quantum regimes. Development of quantum heat engines (QHEs) requires emerging field of quantum thermodynamics. Studies of QHEs debate whether quantum coherence can be used as a resource. We explore an alternative where it can function as an effective catalyst. We propose a QHE which consists of a photon gas inside an optical cavity as the working fluid and quantum coherent atomic clusters as the fuel. Utilizing the superradiance, where a cluster can radiate quadratically faster than a single atom, we show that the work output becomes proportional to the square of the number of the atoms. In addition to practical value of cranking up QHE, our result is a fundamental difference of a quantum fuel from its classical counterpart.
description: 10 pages, 2 figures. Revised version. Newly added discussions on cost of coherence and effects of atomic decoherence. To be published in Nature Scientific Reports
PER UNA LOGICA DELL'UMANO. ANTROPOLOGIA FILOSOFICA E WERTLEHRE IN WINDELBAND, RICKERT E LASK
Creators: name: REDAELLI, ROBERTO
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Il presente lavoro si pone un duplice obiettivo. In primo luogo, esso intende rintracciare, nell?alveo dell?ideale linea di pensiero che unisce le filosofie di Windelband, Rickert e Lask, una teoria formale dell?uomo, una logica dell?umano, tesa a riconoscere le strutture invarianti della vita umana nel mondo. Tale logica informa trasversalmente il procedere filosofico dei tre pensatori, pervenendo all?individuazione di diverse categorie proprie dell?umano (l?essere mondano, storico ed etico) ripensate attraverso il prisma concettuale offerto dal dispositivo valoriale. A questo primo obiettivo, di natura squisitamente storiografica, con il quale si intende riconoscere un?indagine formale sull?uomo entro l?intricata trama concettuale ordita dalle ricerche metodologiche dei filosofi in questione, si lega il secondo: vagliare l?attualit� e i limiti di tale teoria. Sottoposta al vaglio del presente, la logica dell?umano si rivela ancora feconda sotto alcuni aspetti (la rivalutazione della dimensione corporea del soggetto umano, una peculiare nozione di teleologismo, il concetto di soggetto etico), i quali possono concorre ancora oggigiorno alla riproposizione della Menschenfrage. A partire da questo duplice obiettivo, il presente lavoro propone di ripensare lo statuto del neocriticismo di Windelband, Rickert e Lask alla luce di motivi antropologici, senza, tuttavia, postulare una qualche diretta parentela tra tale movimento di pensiero e l?antropologia filosofica inaugurata, negli anni venti del Novencento, da Scheler, Plessner e Gehlen.
АУДИТ РАСЧЕТОВ С ПОКУПАТЕЛЯМИ И ЗАКАЗЧИКАМИ И ЕГО ЗНАЧЕНИЕ В СНИЖЕНИИ РИСКОВ ОРГАНИЗАЦИИ
Creators: name: А. В. Антюшина
name: А. А. Бжассо
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: аудит
цели и задачи аудита
расчеты
покупатели и заказчики
существенность
аудиторский риск
процедуры
этапы проведения аудита
бухгалтерский учет
кризис
риски.

description: В статье рассмотрены понятие аудита, цели и задачи учета расчетов с покупателями и заказчиками, в современных условиях. Обоснована необходимость оценки существенности и аудиторского риска в ходе аудита. Описано, значение аудита учета расчетов с покупателями и заказчиками для снижения рисков организации. Отражены процедуры, которые необходимо выполнить в ходе проведения аудита учета расчетов с покупателями и заказчиками.
Viral vector-based gene therapies in the clinic
Creators: name: Anselmo, A.C.
name: Mitragotri, S.
name: Zhao, Z.
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: Gene therapies are currently one of the most investigated therapeutic modalities in both the preclinical and clinical settings and have shown promise in treating a diverse spectrum of diseases. Gene therapies aim at introducing a gene material in target cells and represent a promising approach to cure diseases that were thought to be incurable by conventional modalities. In many cases, a gene therapy requires a vector to deliver gene therapeutics into target cells; viral vectors are among the most widely studied vectors owing to their distinguished advantages such as outstanding transduction efficiency. With decades of development, viral vector-based gene therapies have achieved promising clinical outcomes with many products approved for treating a range of diseases including cancer, infectious diseases and monogenic diseases. In addition, a number of active clinical trials are underway to further expand their therapeutic potential. In this review, we highlight the diversity of viral vectors, review approved products, and discuss the current clinical landscape of in vivo viral vector-based gene therapies. We have reviewed 13 approved products and their clinical applications. We have also analyzed more than 200 active trials based on various viral vectors and discussed their respective therapeutic applications. Moreover, we provide a critical analysis of the major translational challenges for in vivo viral vector-based gene therapies and discuss possible strategies to address the same.
ОСОБЕННОСТИ АДАПТАЦИИ ПЕРСОНАЛА В КАЛУЖСКОЙ ТАМОЖНЕ
Creators: name: Р. Р. Ахмедзянов
name: Е. В. Ключникова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: таможенные органы
персонал
адаптация
поведение
условия труда
потенциал.

description: На протяжении всей деятельности таможенные органы сталкивается с проблемой адаптации персонала. Вновь вышедший на работу сотрудник включается в систему организационных требований, занимая в ней определенную позицию. Каждой должности соответствует совокупность должностных требований, норм, правил поведения. От сотрудника ожидается соответствие этой позиции поведения. В статье рассматриваются особенности адаптации персонала в Калужской таможне. Большое внимание уделяется работе наставников и воспитательной работе проводимой кадровой службой таможенных органов.
Relaxors, spin-, Stoner- and cluster-glasses
Creators: name: Sherrington, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: It is argued that the main characteristic features of displacive relaxor ferrolectrics of the form ${\rm{A(B,B')}\rm{O}}_3$ with isovalent ${\rm{B,B'}}$ can be explained and understood in terms of a soft-pseudospin analogue of conventional spin glasses as extended to itinerant magnet systems. The emphasis is on conceptual comprehension and on stimulating new perspectives with respect to previous and future studies. Some suggestions are made for further studies both on actual real systems and on test model systems to probe further. The case of heterovalent systems is also considered briefly.
Evaluation of Surface Modified Live Biotherapeutic Products for Oral Delivery
Creators: name: Anselmo, A.C.
name: Vargason, A.M.
Publisher: name: American Chemical Society
Year: 2021

description: Live biotherapeutic products (LBPs), including symbiotic and genetically engineered bacteria, are a promising class of emerging therapeutics that are widely investigated both preclinically and clinically for their oral delivery to the gastrointestinal (GI) tract. One emergent delivery strategy involves the direct functionalization of LBP surfaces through noncovalent or covalent modifications to control LBP interactions with the GI microenvironment, thereby improving their viability, attachment, or therapeutic effect. However, unlike other therapeutic modalities, LBPs are living organisms which present two unique challenges for surface modifications: (1) this approach can directly interfere with key LBP biological processes (e.g., colonization, metabolite secretion) and (2) modification can be variable due to the dynamic nature of LBP surfaces. Collectively, these factors remain uncharacterized as they relate to the oral delivery of LBPs. Herein, we leverage our previously reported surface modification platform, which enables LBP surface-presentation of targeting ligands, to broadly evaluate and characterize surface modifications on LBPs. Specifically, we evaluate how LBP growth affects the dilution of surface-presented targeting ligands and the subsequent loss of specific target attachment over time. Next, we describe key surface modification parameters (e.g., concentration, residence time) that can be optimized to facilitate LBP target attachment. We then characterize how bioconjugation influences the suitability of LBPs for oral delivery by evaluating their growth, viability, storage, toxicity against mammalian cells, and in vivo colonization. Broadly, we describe key parameters that influence the performance of surface modified LBPs and subsequently outline an experimental pipeline for characterizing and evaluating their suitability for oral delivery.
ПРИЧИНЫ АДАПТАЦИИ ПЕРСОНАЛА В ТАМОЖЕННЫХ ОРГАНАХ
Creators: name: Р. Р. Ахмедзянов
name: Е. В. Ключникова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: таможенные органы
персонал
адаптация
поведение
условия труда
потенциал.

description: На сегодняшний момент современные компании, поняв нужность адаптации, разрабатывают и применяют методики, направленные на максимально быстрое и эффективное включение нового работника в деловую жизнь фирмы. Важным моментом в улучшении процесса адаптации являются сплочение коллектива, разрешение конфликтных ситуаций, улучшение адаптации новичка в коллективе, индивидуальные психологические консультации сотрудников и руководителей, развитие наставничества. В статье рассматриваются этапы адаптации сотрудников таможенных органов за счет создания команд единомышленников, объединенных ценностями организации и корпоративной этикой.
Surface Modifications for Improved Delivery and Function of Therapeutic Bacteria
Creators: name: Vargason, A.M.
name: Anselmo, A.C.
name: Santhosh, S.
Publisher: name: Wiley-VCH Verlag
Year: 2020

description: Live therapeutic bacteria (LTBs) hold promise to treat microbiome-related diseases. However, few approaches to improve the colonization of LTBs in the gastrointestinal tract exist, despite colonization being a prerequisite for efficacy of many LTBs. Here, a modular platform to rapidly modify the surface of LTBs to enable receptor-specific interactions with target surfaces is reported. Inspired by bacterial adhesins that facilitate colonization, synthetic adhesins (SAs) are developed for LTBs in the form of antibodies conjugated to their surface. The SA platform is nontoxic, does not alter LTB growth kinetics, and can be used with any antibody or bacterial strain combination. By improving adhesion, SA-modified bacteria demonstrate enhanced in vitro pathogen exclusion from cell monolayers. In vivo kinetics of SA-modified LTBs is tracked in the feces and intestines of treated mice, demonstrating that SA-modified bacteria alter short-term intestinal transit and improve LTB colonization and pharmacokinetics. This platform enables rapid formation of an intestinal niche, leading to an increased maximum concentration and a 20% improvement in total LTB exposure. This work is the first application of traditional pharmacokinetic analysis to design and evaluate LTB drug delivery systems and provides a platform toward controlling adhesion, colonization, and efficacy of LTBs.
Abell 1033: birth of a radio phoenix
Creators: name: de Gasperin, F.
name: Ogrean, G. A.
name: van Weeren, R. J.
name: Dawson, W. A.
name: Brüggen, M.
name: Bonafede, A.
name: Simionescu, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Extended steep-spectrum radio emission in a galaxy cluster is usually associated with a recent merger. However, given the complex scenario of galaxy cluster mergers, many of the discovered sources hardly fit into the strict boundaries of a precise taxonomy. This is especially true for radio phoenixes that do not have very well defined observational criteria. Radio phoenixes are aged radio galaxy lobes whose emission is reactivated by compression or other mechanisms. Here, we present the detection of a radio phoenix close to the moment of its formation. The source is located in Abell 1033, a peculiar galaxy cluster which underwent a recent merger. To support our claim, we present unpublished Westerbork Synthesis Radio Telescope and Chandra observations together with archival data from the Very Large Array and the Sloan Digital Sky Survey. We discover the presence of two sub-clusters displaced along the N-S direction. The two sub-clusters probably underwent a recent merger which is the cause of a moderately perturbed X-ray brightness distribution. A steep-spectrum extended radio source very close to an AGN is proposed to be a newly born radio phoenix: the AGN lobes have been displaced/compressed by shocks formed during the merger event. This scenario explains the source location, morphology, spectral index, and brightness. Finally, we show evidence of a density discontinuity close to the radio phoenix and discuss the consequences of its presence.
description: accepted MNRAS