title: ÐÐ¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ 161Tb Ð´Ð»Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ¹ Ð½Ð¸Ð·ÐºÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐ½ÑÐ¼Ð¸ Î²-ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸, ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð°Ð¼Ð¸ ÐÐ¶Ðµ Ð¸ ÐºÐ¾Ð½Ð²ÐµÑÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Possibilities of 161Tb production for targeted radionuclide therapy of tumors by low-energy Î²-particles, Auger and conversion electrons
Creators: name: ÐÐ¾Ð³Ð´Ð°Ð½Ð¾Ð²Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¾Ð¶Ðµ-ÑÐ»ÐµÐºÑÑÐ¾Ð½Ñ
ÑÐµÐ°ÐºÑÐ¾Ñ
ÑÐ¸ÐºÐ»Ð¾ÑÑÐ¾Ð½
Ð¾Ð±Ð¾Ð³Ð°ÑÐµÐ½Ð½ÑÐ¹ Ð³Ð°Ð´Ð¾Ð»Ð¸Ð½Ð¸Ð¹
Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ°ÐºÑÐ¸Ð¸
ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ
radionuclide therapy
auger electrons
reactor
cyclotron
enriched gadolinium
activity
reaction cross sections
radiochemical isolation

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ 161Tb Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼Ð°Ð»ÑÑ ÑÐ½ÐµÑÐ³Ð¸Ð¹ Ð² ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ðµ Ð¸ ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ð¼ Ð´Ð»Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐµÐ³Ð¾ Ð² ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹. 161Tb â Ð±ÐµÑÐ°-Ð¸Ð·Ð»ÑÑÐ°ÑÐµÐ»Ñ Ñ Ð¼Ð°Ð»ÑÐ¼Ð¸ ÑÐ½ÐµÑÐ³Ð¸ÑÐ¼Ð¸ Ð±ÐµÑÐ°-ÑÐ°ÑÑÐ¸Ñ, Ð½Ð¾ ÑÐ°ÐºÐ¶Ðµ Ð¾Ð½ Ð¸Ð¼ÐµÐµÑ Ð²ÑÑÐ¾ÐºÑÑ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÑ ÐºÐ¾Ð½Ð²ÐµÑÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¸ ÐÐ¶Ðµ-ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð¾Ð², Ð¿Ð¾ÑÑÐ¾Ð¼Ñ Ð¸Ð¼ Ð¼Ð¾Ð¶Ð½Ð¾ Ð»ÐµÑÐ¸ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð¼Ð°Ð»Ð¾Ð³Ð¾ Ð¸ Ð±Ð¾Ð»ÑÑÐ¾Ð³Ð¾ ÑÐ°Ð·Ð¼ÐµÑÐ°. ÐÐ°ÑÐ°Ð±Ð¾ÑÐºÐ° 161Tb Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° ÑÐµÐ°ÐºÑÐ¾ÑÐµ Ð¸ ÑÐ¸ÐºÐ»Ð¾ÑÑÐ¾Ð½Ðµ Ð¿Ð¾ ÑÐµÐ°ÐºÑÐ¸ÑÐ¼ 160Gd(n,Î³)161Gdâ161Tb Ð¸ 160Gd(d,x)161Tb. ÐÑÐ»Ð¸ ÑÑÐ¾ÑÐ½ÐµÐ½Ñ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ ÑÐµÑÐµÐ½Ð¸Ð¹ ÑÐµÐ°ÐºÑÐ¸Ð¸ 160Gd(d,x)161Tb Ð´Ð»Ñ Ð´ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð² Ð¸ ÑÐµÐ°ÐºÑÐ¸Ð¸ 160Gd(n,Î³)161Gdâ161Tb Ð´Ð»Ñ ÑÐ¿Ð¸ÑÐµÐ¿Ð»Ð¾Ð²ÑÑ Ð¸ Ð±ÑÑÑÑÑÑ Ð½ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð² Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼Ð°Ð»ÑÑ ÑÐ½ÐµÑÐ³Ð¸Ð¹, ÑÐ°Ðº ÐºÐ°Ðº Ð¾Ð½Ð¸ Ð¼Ð°Ð»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ñ Ð´Ð»Ñ Ð´ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð² Ð½Ð¸Ð¶Ðµ Ed&lt;10 ÐÑÐ Ð¸ Ð½ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð² Ð²ÑÑÐµ En&gt;3 ÐÑÐ. ÐÐ»Ñ ÑÐµÐ°ÐºÑÐ¸Ð¹ 160Gd(d,x)161Tb Ð¸ 160Gd(n,Î³)161Gdâ161Tb Ð±ÑÐ»Ð¸ ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ñ Ð¸ Ð¾ÑÐµÐ½ÐµÐ½Ñ Ð²ÑÑÐ¾Ð´Ñ Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐ¸ÑÑÐ¾ÑÐ° ÑÐµÐ»ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ° Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¿ÐµÐºÑÑÐ° Ð½ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð² Ð¸ Ð´ÐµÐ¹ÑÑÐ¾Ð½Ð¾Ð², ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð¾Ð±Ð¾Ð³Ð°ÑÐµÐ½Ð¸Ñ Ð¸ ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐ¾ÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼ÑÑ ÑÑÐ°ÑÑÐ¾Ð²ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð², Ð²ÑÐµÐ¼ÐµÐ½Ð¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸, ÑÑÐ¾ (n,Î³) ÐºÐ°Ð½Ð°Ð» ÑÐ²Ð»ÑÐµÑÑÑ Ð½Ð°Ð¸Ð»ÑÑÑÐ¸Ð¼ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ¾Ð¼ Ð´Ð»Ñ Ð½Ð°ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ð³Ð¾ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° 161Tb. ÐÐ¾ ÐµÑÐ»Ð¸ Ð¼Ñ Ð½Ðµ ÑÐ°ÑÐ¿Ð¾Ð»Ð°Ð³Ð°ÐµÐ¼ Ð¿Ð¾Ð±Ð»Ð¸Ð·Ð¾ÑÑÐ¸ ÑÐµÐ°ÐºÑÐ¾ÑÐ¾Ð¼, ÑÐ¾ Ð¼Ð¾Ð¶Ð½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ ÑÐ¸ÐºÐ»Ð¾ÑÑÐ¾Ð½ Ð´Ð»Ñ Ð½Ð°ÑÐ°Ð±Ð¾ÑÐºÐ¸ 161Tb Ð¿Ð¾ ÐºÐ°Ð½Ð°Ð»Ð°Ð¼ (d,n), (d,2n) Ð¸ (d,p), Ð½Ð¾ Ð¿ÑÐ¸ ÑÑÐ»Ð¾Ð²Ð¸Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼ÐµÑÐ°Ð»Ð»Ð¸ÑÐµÑÐºÐ¸Ñ Ð¾Ð±Ð¾Ð³Ð°ÑÐµÐ½Ð½ÑÑ Ð³Ð°Ð´Ð¾Ð»Ð¸Ð½Ð¸ÐµÐ²ÑÑ Ð¼Ð¸ÑÐµÐ½ÐµÐ¹.
description: The given work is devoted to obtaining 161Tb in the low energy region in the quantity and quality necessary for its application in radionuclide therapy of tumors. 161Tb is a beta emitter with low beta particle energies, but it also has a high component of conversion and Auger electrons, so it can be used to treat small and large tumors. The 161Tb production was carried out on the reactor and cyclotron by the reactions 160Gd(n,Î³)161Gdâ161Tb and 160Gd(d,x)161Tb. The energy dependences of the 160Gd(d,x)161Tb reaction cross sections for deuterons and the 160Gd(n,Î³)161Gdâ161Tb reaction for epithermal and fast neutrons in the low energy region have been clarified, as they are poorly studied for deuterons below Ed&lt;10 MeV and neutrons above En&gt;3 MeV. For the reactions 160Gd(d,x)161Tb and 160Gd(n,Î³)161Gdâ161Tb, the yields and radionuclide purity of the target product were calculated and evaluated as a function of the neutron and deuteron energy spectrum, the degree of enrichment and chemical purity of the starting materials used, and the irradiation time. The results showed that the (n,Î³) channel is the best option for producing the required amount of 161Tb. But if we dont have a reactor nearby, we can use a cyclotron to produce 161Tb through the (d,n), (d,2n), and (d,p) channels, but under the condition that metal enriched gadolinium targets are used.