cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Caloric dose-responsive genes in blood cells differentiate the metabolic status of obese men
Creators: name: Gille, Doreen
name: Zangger, Nadine
name: Soneson, Charlotte
name: Bütikofer, Ueli
name: Delorenzi, Mauro
name: Schwander, Flurina
name: Kopf, Katrin Annika
name: Chollet, Magali
name: Walther, Barbara
name: Laederach, Kurt
name: Vergères, Guy
Publisher: name: Elsevier
Year: 2017

description: We have investigated the postprandial transcriptional response of blood cells to increasing caloric doses of a meal challenge to test whether the dynamic response of the human organism to the ingestion of food is dependent on metabolic health. The randomized crossover study included seven normal weight and seven obese men consuming three doses (500/1000/1500 kcal) of a high-fat meal. The blood cell transcriptome was measured before and 2, 4, and 6 h after meal ingestion (168 samples). We applied univariate and multivariate statistics to investigate differentially expressed genes in both study groups. We identified 624 probe sets that were up- or down-regulated after the caloric challenge in a dose-dependent manner. These transcripts were most responsive to the 1500 kcal challenge in the obese group and were associated with postprandial insulin and oxidative phosphorylation. Furthermore, the data revealed a separation of the obese group into individuals whose response was close to the normal weight group and individuals with a transcriptional response indicative of a loss of metabolic flexibility. The molecular signature provided by the postprandial transcriptomic response of blood cells to increasing caloric doses of a high-fat meal challenge may represent a sensitive way to evaluate the qualitative impact of food on human health.
MOESM3 of Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara
Creators: name: Mahamadou Thera
name: Drissa Coulibaly
name: Abdoulaye Kone
name: Guindo, Ando
name: Traore, Karim
name: Abdourhamane Sall
name: Diarra, Issa
name: Modibo Daou
name: Idrissa Traore
name: Tolo, Youssouf
name: Sissoko, Mady
name: Amadou Niangaly
name: Arama, Charles
name: Mounirou Baby
name: Bourema Kouriba
name: Mahamadou Sissoko
name: Issaka Sagara
name: Ousmane Toure
name: Amagana Dolo
name: Dapa Diallo
name: Remarque, Edmond
name: Chilengi, Roma
name: Ramadhani Noor
name: Sesay, Sanie
name: Thomas, Alan
name: Kocken, Clemens
name: Faber, Bart
name: Egeruan Imoukhuede
name: Leroy, Odile
name: Ogobara Doumbo
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Abnormal laboratory parameters grading intensity.
Additional file 16: Figure S15. of Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Creators: name: Genshaft, Alex
name: Shuqiang Li
name: Gallant, Caroline
name: Darmanis, Spyros
name: Prakadan, Sanjay
name: Ziegler, Carly
name: Lundberg, Martin
name: Fredriksson, Simon
name: Hong, Joyce
name: Regev, Aviv
name: Livak, Kenneth
name: Landegren, Ulf
name: Shalek, Alex
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Analyzing population lysate dilution data. The Ct values observed for the two PEA standards: the extension control (a) and oligo reference (b). Across time points (0 hr = purple, 24 hr = green, 48 hr = blue) and cell dilutions, the deviations from the lysis buffer control are quite small except for the 42.5 and 21.25 cell equivalent dilutions (0.05 and 0.01 probability cutoffs from the background shown in green and gray, respectively). In these deviations are quite small except for the 42.5 and 21.25 cell equivalent dilutions. Therefore, those measurements are excluded from the dilution plots in Additional files 2, 3, and 4: Figures S1, S2, and S3. (PDF 143 kb)
2023DESARROLLO DE UN VIDEOJUEGO QUE EJERCE LA FUNCIÓN DE SER UNA HERRAMIENTA DE APOYO EMOCIONAL PARA ADOLESCENTES Y ADULTOS
Creators: name: Gamboa Rodríguez, Patricia Guadalupe
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390303
subject: Higher education
classificationCode: 390305
subject: Professional education and training
classificationCode: 520101
subject: Child and adolescent development
classificationCode: 520102
subject: Educational psychology
classificationCode: 461202
subject: Empirical software engineering
classificationCode: 460105
subject: Applications in social sciences and education

description: El presente estudio resalta la relevancia de abordar los cambios en la vida de los jóvenes, en particular durante la preadolescenciay la adolescencia, así como la importancia de reconocer la relación entre los videojuegos y el manejo de las emociones. El videojuego propuesto se basa en una comprensión sólida de estas dinámicas y tiene el potencial de ser una herramienta efectiva para brindar apoyo emocional a su audiencia. Este trabajo tiene como objetivo demostrar que los videojuegos no solo pueden ser herramientas de entretenimiento, sino también valiosas herramientas terapéuticas que a la par que pueden mejorar el bienestar emocional y ayudar a las personas a sobrellevar y adaptarse a las transiciones y cambios de la vida también pueden brindar una experiencia entretenida. La investigación presentada en esta tesis tiene el potencial de arrojar luz sobre cómo aprovechar plenamente el poder de los videojuegos para apoyar a las personas en su viaje de adaptación a situaciones de cambio, promoviendo una mayor comprensión y apertura hacia esta innovadora forma de terapia y apoyo emocional.Palabras Clave: Videojuego, cambios, emociones
Carex capitata L.
Creators: name: Info Flora
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Carex
Carex capitata

description: Carex capitata L.
Art ISFS: 84800 Checklist: 1009500 Cyperaceae Carex Carex capitata L.
Bestimmungsschlüssel
ZusammenfassungKEINE ANGABE
Ökologie
Lebensraum Lebensraumnach Delarze & al. 2015
KEINE ANGABE
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Nomenklatur
Gültiger Name (Checklist 2017):Carex capitataL.
Volksname
Deutscher Name: -- Nom français: -- Nome italiano: --
Übereinstimmung mit anderen Referenzwerken
RelationNomReferenzwerkeNo=Carex capitata L.Index synonymique 199684800=Carex capitata L.Landolt 1977459=Carex capitata L.SISF/ISFS 284800
= Taxon stimmt mit akzeptiertem Taxon überein (Checklist 2017)  Taxon enthält (neben anderen) auch das akzeptierte Taxon (Checklist 2017)
Status Indigenat: -
Liste der gefährdeten Pflanzen IUCN(nach Walter & Gillett 1997): Nein
description: Published as part of Info Flora, 2021,
Additional file 12: Figure S11. of Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Creators: name: Genshaft, Alex
name: Shuqiang Li
name: Gallant, Caroline
name: Darmanis, Spyros
name: Prakadan, Sanjay
name: Ziegler, Carly
name: Lundberg, Martin
name: Fredriksson, Simon
name: Hong, Joyce
name: Regev, Aviv
name: Livak, Kenneth
name: Landegren, Ulf
name: Shalek, Alex
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 60506 Virology

description: Analyzing gene trajectories through a time course of PMA stimulation. Genes quantified as both RNA and protein were made binary for each value based on detection or lack thereof. The vector of the proportion of cells in the four quadrants of detected and undetected for RNA and protein across the three stimulation time points were clustered using Spearman correlation. Clusters are divided using a distance metric of 0.75; representative trajectories through time (depicted by color 0 hr = purple, 24 hr = green, 48 hr = blue) are shown for the genes evaluated in situ with the bottom left quadrant representing undetected protein and undetected RNA, the bottom right quadrant representing undetected protein and detected RNA, the top left quadrant representing detected protein and undetected RNA, and the top right quadrant representing detected protein and detected RNA. The size of the dots corresponds to the fraction of cells in that quadrant. (PDF 179 kb)
Laser Patterning of High‐Mass‐Loading Graphite Anodes for High‐​Performance Li‐​Ion Batteries
Creators: name: Dubey, Romain
name: Zwahlen, Marcel-David
name: Shynkarenko, Yevhen
name: Yakunin, Sergii
name: Fuerst, Axel
name: Kovalenko, Maksym V
name: Kravchyk, Kostiantyn V.
Publisher: name: Wiley
Year: 2021

description: Given the ongoing efforts to build Li-ion batteries with higher volumetric energy and power densities, the research on enhancing Li-ion transport within compressed high-mass-loading electrodes at fast cycling conditions is imperative. In this work, we show that the rate capability of graphite electrodes with high areal capacity of 4.5 mAh cm2 and density of 1.79 g cm3 (15% of porosity) can be considerably improved by laser patterning, namely by the fabrication of arrays of vertically aligned channels serving as diffusion paths for rapid Li-ion transport. Resultant laser patterned graphite electrodes delivered enhanced volumetric capacity as compared to that of non-patterned electrodes (450 vs. 396 mAh cm3 at C/2 rate). The reduction of the total steady-state concentration drop within the graphite electrodes after their patterning was also assessed.
Uniparodentata Wang & Cao 1993
Creators: name: Das, Priyanka
name: Chandra, Kailash
name: Gupta, Devanshu
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Uniparodentata

description: Genus Uniparodentata Wang & Cao, 1993
Type species. Epilachna paramagna Pang & Mao, 1979.
description: Published as part of Das, Priyanka, Chandra, Kailash & Gupta, Devanshu, 2020, Redescription of Afissa gibbera (Crotch, 1874) and Uniparodentata circummaculata (Pang & Mao, 1977) (Coccinellidae: Epilachnini) from India, pp. 248-256 in Zootaxa 4822 (2) on page 252, DOI: 10.11646/zootaxa.4822.2.6, http://zenodo.org/record/4401509
Additional file 6: Figure S2. of Differential variability and correlation of gene expression identifies key genes involved in neuronal differentiation
Creators: name: Ando, Tatsuya
name: Kato, Ryuji
name: Honda, Hiroyuki
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Co-expression networks at six time points. (PDF 1213 kb)
A Concept for Improving Cross-Sector Care by a Mobile Patient Navigator App
Creators: name: Denecke, Kerstin
name: Kyburz, Philip
name: Gfeller, Sascha
name: Deng, Yihan
name: Bürkle, Thomas
Publisher: name: IOS Press
Year: 2018

description: Hip and knee joint prosthetic implants are common surgical interventions in Switzerland, as well as in other countries. Different care providers are involved in the care process which constitutes a potential risk of inefficiency and communication deficits. A patient can get lost on his cross-sectoral clinical pathway, miss appointments or underestimate the relevance of certain control visits or examinations. To address this, we introduce a concept for a mobile application that guides patients along the cross-sectoral clinical pathway. The information on appointments is consistently retrieved from information systems at the care provider's side. This facilitates the coordination of activities and appointments not only for the patient, but also for the care providers. The aim is to promote the patients' autonomy, to support their management of appointments, to increase the understanding for their clinical condition and to improve their adherence to the prescribed measures – all of which lead to an improved outcome. Another aim is to increase patient satisfaction in terms of adequate information and quality of treatment. The advantages and disadvantages of the concept will be discussed. goes here.
Additional file 1: Table S1. of Analysis of age-dependent trends in Ov16 IgG4 seroprevalence to onchocerciasis
Creators: name: Golden, Allison
name: Faulx, Dunia
name: Kalnoky, Michael
name: Stevens, Eric
name: Yokobe, Lindsay
name: Peck, Roger
name: Potochoziou Karabou
name: MĂŠba Banla
name: Ramakrishna Rao
name: Kangi Adade
name: Gantin, Richard
name: Kossi Komlan
name: Soboslay, Peter
name: Santos, Tala De Los
name: Domingo, Gonzalo
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Village name, number of study participants, Ov16 prevalence and MF prevalence values used to generate Fig.Â 4b. (DOCX 15Â kb)
Development of a diet quality score and adherence to the Swiss dietary recommendations for vegans
Creators: name: Bez, Natalie Sara
name: Haddad, Joyce
name: Tedde, Giulia Simona
name: Rose, Karolin
name: Ivanov, Aljoscha Vladimir
name: Milazzo, Marina
name: Wickart, Joëlle
name: Casale, Giulia
name: D'Ascanio, Michele
name: Van Der Horst, Klazine
name: Herter-Aeberli, Isabelle
name: Bogl, Leonie-Helen
Publisher: name: BMC Springer Nature
Year: 2024
Subjects: Diet index Diet quality score Dietary patterns Vegan diet Vegan dietary guidelines Vegan recommendations

description: Background: Vegan diets have recently gained popularity in Switzerland as well as globally. The aim of the present study was to develop a diet quality score for vegans (DQS-V) based on the Swiss dietary recommendations for vegans. Methods: The dataset included 52 healthy vegan adults. Dietary intake data were assessed by three-day weighed food records. Body weight and height were measured, and a venous blood sample for the analysis of vitamin and mineral status was collected. Spearman rank correlation coefficients were used due to not-normally distributed data. Dietary patterns were identified using principal component analysis (PCA). Results: The DQS-V score (mean ± SD) was 48.9 ± 14.7. Most vegans adhered to the recommended portions of vegetables, vitamin C-rich vegetables, fruits, omega-3-rich nuts, fats and oils, and iodized salt. However, the intake of green leafy vegetables, vitamin C-rich fruits, wholegrains, legumes, nuts and seeds, selenium-rich nuts, zero caloric liquid, and calcium-fortified foods was suboptimal. The sample overconsumed sweet-, salty-, fried foods, and alcohol. The DQS-V had a significantly positive correlation with intakes of fibre, polyunsaturated fatty acids, potassium, zinc, and phosphorus intakes (p's < 0.05) but was negatively correlated with vitamin B12 and niacin intakes (p's < 0.05). Two dietary patterns were derived from PCA: 1) refined grains and sweets and 2) wholegrains and nuts. The correlation between the DQS-V and the first dietary pattern was negative (- 0.41, p = 0.004) and positive for the second dietary pattern (0.37, p = 0.01). The refined grains and sweets dietary pattern was inversely correlated with beta-carotene status (- 0.41, p = 0.004) and vitamin C status (r = - 0.51, p = 0.0002). Conclusion: The newly developed DQS-V provides a single score for estimating diet quality among vegan adults. Further validation studies examining the DQS-V in relation to an independent dietary assessment method and to biomarkers of nutritional intake and status are still needed before the general application of the DQS-V. Keywords: Diet index; Diet quality score; Dietary patterns; Vegan diet; Vegan dietary guidelines; Vegan recommendations.
Additional file 3: of Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma
Creators: name: Borasi, Giovanni
name: Nahum, Alan
name: Margarethus Paulides
name: Gibin Powathil
name: Russo, Giorgio
name: Fariselli, Laura
name: Lamia, Debora
name: Cirincione, Roberta
name: Forte, Giusi
name: Borrazzo, Cristian
name: Caccia, Barbara
name: Castro, Elisabetta Di
name: Pozzi, Silvia
name: Gilardi, Maria
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Location of isolines in ablative and HT US pulses. (DOCX 19 kb)
Methodische Aspekte des chorischen Sprechens
Creators: name: Kiesler, Julia
Publisher: name: Frank & Timme
Year: 2024

description: Das zeitgenössische Theater bringt Arbeits- und Erscheinungsformen gesprochener Sprache hervor, die eine veränderte Perspektive auf Prozesse des Darstellens und Sprechens auf der Bühne werfen. Als ein Beispiel für einen performativen Umgang mit dem Text, beschreibt der Artikel Möglichkeiten für eine chorisch-musikalische Texterarbeitung.
Metabolic discrimination of Thymus, Zataria, and Ziziphora genera by NMR-based metabolomics
Creators: name: Aalinezhad, Shokoufeh
name: Emami, Seyed Ahmad
name: Iranshahi, Mehrdad
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Thyme is a commercial spice widely used in food, cosmetics, and pharmaceutical industries. Three popular genera in food and traditional medicine, including Zataria Boiss., Thymus L., and Ziziphora L., are considered as thyme-like plants in Iran. Thyme has been standardised based on phenolic monoterpenes, which are abundant in the essential oils of these three genera. Apart from monoterpenes, the flavonoid naringenin, the triterpene oleanolic acid, and phytosterols such as β-sitosterol were abundant in Zataria, Thymus, and Ziziphora samples, respectively. Therefore, employing current analytical techniques on the basis of thymol and carvacrol may be insufficient to differentiate Thymus spp from similar medicinal plants including Zataria and Ziziphora spp. In this study, we applied NMR-based metabolomics using multivariate analyses to develop quality control of thyme and their similar products. Our findings revealed that NMR-based metabolomics can be a useful approach in differentiating Zataria, Thymus, and Ziziphora.
Universal consistency of the $k$-NN rule in metric spaces and Nagata dimension. II
Creators: name: Kumari, Sushma
name: Pestov, Vladimir G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: 62H30, 54F45

description: We continue to investigate the $k$ nearest neighbour ($k$-NN) learning rule in complete separable metric spaces. Thanks to the results of Cérou and Guyader (2006) and Preiss (1983), this rule is known to be universally consistent in every such metric space that is sigma-finite dimensional in the sense of Nagata. Here we show that the rule is strongly universally consistent in such spaces in the absence of ties. Under the tie-breaking strategy applied by Devroye, Györfi, Krzyżak, and Lugosi (1994) in the Euclidean setting, we manage to show the strong universal consistency in non-Archimedian metric spaces (that is, those of Nagata dimension zero). Combining the theorem of Cérou and Guyader with results of Assouad and Quentin de Gromard (2006), one deduces that the $k$-NN rule is universally consistent in metric spaces having finite dimension in the sense of de Groot. In particular, the $k$-NN rule is universally consistent in the Heisenberg group which is not sigma-finite dimensional in the sense of Nagata as follows from an example independently constructed by Korányi and Reimann (1995) and Sawyer and Wheeden (1992).
description: Latex 2e, 27 pages, 1 figure. Minor revisions to conform with the last set of journal page proofs: two typos corrected, the bibliography rearranged in the order of citations (the ESAIM:PS home style), and two articles that were no longer cited removed
Additional file 4: Figure S3. of Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Creators: name: Genshaft, Alex
name: Shuqiang Li
name: Gallant, Caroline
name: Darmanis, Spyros
name: Prakadan, Sanjay
name: Ziegler, Carly
name: Lundberg, Martin
name: Fredriksson, Simon
name: Hong, Joyce
name: Regev, Aviv
name: Livak, Kenneth
name: Landegren, Ulf
name: Shalek, Alex
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Standard RNA probe curves using lysed and diluted MCF7 cells. Two-fold dilutions of population lysate were backloaded into the C1 IFC and processed according to the PEA/STA protocol. Shown here are the STA measurements with the y-axis values representing ∆Ct values from lysis buffer alone or a threshold value of 24 if undetected in pure lysate. Certain assays (e.g. ACTB_R) display a “hook” effect, as seen in Additional files 2 and 3: Figures S1 and S2, potentially due to reagent saturation. Each data point plotted is the average of eight separate capture sites in the C1 IFC with error bars showing the standard error of the mean. Gray (green) dashes show the level above which the probability for a detection event being real is p = 0.01 (0.05). Points used for fitting the red trend line are colored blue, the background plot color indicates which treatment cells were taken from (0 hr = purple, 24 hr = green, 48 hr = blue). Genes are categorized as (a) usable or (b) unusable. (PDF 1087 kb)
Additional file 5: Figure S1. of Differential variability and correlation of gene expression identifies key genes involved in neuronal differentiation
Creators: name: Ando, Tatsuya
name: Kato, Ryuji
name: Honda, Hiroyuki
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Gene expression profile of the Yamanaka factors during neuronal differentiation. (PDF 8 kb)
Relative age effects in Swiss junior soccer and their relationship with playing position
Creators: name: Romann, Michael
name: Fuchslocher, Jörg
Publisher: name: Taylor & Francis
Year: 2013
Subjects: Talent development Selection Female soccer Birth date Children Relative age effect

description: Abstract Relative age effects (RAEs) refer to age differences between children in the same selection year. The present study investigated the prevalence of RAEs and their link to playing positions in Swiss junior soccer. Swiss male junior soccer players (n 50,581) representing 11% of the age-matched population members of extra-curricular soccer teams were evaluated to determine the influence of RAEs on Swiss junior soccer. Subgroups were the national talent development programme (n 2880), and U-15 to U-21 national teams (n 630). While no RAEs were found for the self-selected extracurricular soccer teams or for the U-20 teams (P 0.05), significant RAEs were found for talent development and the national U-15 to U-19 and U-21 teams (PB0.01). Additionally, defenders born early in the year were significantly overrepresented compared with goalkeepers, midfielders and strikers (PB0.05). In Switzerland, RAEs apparently have substantial influence on the talent identification process for U-15 to U-18 teams, significantly influencing the selection of players in talent development teams already at an early age, but do not influence self-selected participation in extracurricular soccer. Additionally, the RAE bias may be a predictor of playing positions in national teams. To minimise RAEs in Swiss soccer, systematic education for all coaches regarding RAEs should be established, in addition to a slotting system with rotating calendar cut-off dates.
Carcharhinus tjutjot Bleeker 1852
Creators: name: Straube, Nicolas
name: White, William T.
name: Ho, Hsuan-Ching
name: Rochel, Elisabeth
name: Corrigan, Shannon
name: Li, Chenhong
name: Naylor, Gavin J. P.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Carcharhinus
Carcharhinus tjutjot

description: Carcharhinus tjutjot (Bleeker, 1852)
Type locality: Jakarta, Java, Indonesia.
The two Taiwanese samples of C. tjutjot included in this analysis formed a single cluster that includes a sample of this species from Indonesian Borneo (GN4597), and is sister to the C. dussumieri clade from the northwestern Indian Ocean (Supplementary Material 1). A recent revision of the C. dussumieri-C. sealei complex informed by both molecular and morphological data resurrected Carcharhinus tjujot as a valid nominal species (White, 2012).
description: Published as part of Straube, Nicolas, White, William T., Ho, Hsuan-Ching, Rochel, Elisabeth, Corrigan, Shannon, Li, Chenhong & Naylor, Gavin J. P., 2013, A DNA sequence-based identification checklist for Taiwanese chondrichthyans, pp. 256-278 in Zootaxa 3752 (1) on page 271, DOI: 10.11646/zootaxa.3752.1.16, http://zenodo.org/record/285357
Graviton Mass Bounds in Very Special Relativity from Binary Pulsar's Gravitational Waves
Creators: name: Santoni, Alessandro
name: Alfaro, Jorge
name: Soto, Alex
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we study the gravitational radiation produced by a keplerian binary system within the context of Very Special Linear Gravity (VSLG), a novel theory of linearized gravity in the framework of Very Special Relativity (VSR) allowing for a gauge-invariant mass $m_g$ of the graviton. For this task, we exploit Effective Field Theory's techniques, which require, among others, the calculation of the squared amplitude of the emission process and therefore the polarization sum for VSLG gravitons. Working in the radiation zone and using the standard energy momentum tensor's expression for keplerian binaries, we derive and study the properties of the VSLG energy loss and period decrease rates, also verifying they reduce to the correct General Relativity limit when sending $m_g\to0$. Finally, using astronomical data from the Hulse-Taylor binary and the Double Pulsar J0737-3039, we obtain an upperbound on the VSLG graviton mass of $m_g\sim 10^{-21}eV$ that, while being comparable to bounds obtained in this same way for other massive gravity models, is still weaker than the kinematical bound $\sim 10^{-22}eV$ obtained from the combined observation of the astronomical events GW170817 and GRB170817A, which should still hold in VSLG.
Additional file 2: of Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma
Creators: name: Borasi, Giovanni
name: Nahum, Alan
name: Margarethus Paulides
name: Gibin Powathil
name: Russo, Giorgio
name: Fariselli, Laura
name: Lamia, Debora
name: Cirincione, Roberta
name: Forte, Giusi
name: Borrazzo, Cristian
name: Caccia, Barbara
name: Castro, Elisabetta Di
name: Pozzi, Silvia
name: Gilardi, Maria
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Reports US pulses fitted with the Parker's equation, using nonlinear least squared method. (DOCX 21 kb)
Cost Effectiveness and Budget Impact of Nivolumab Plus Ipilimumab Versus Platinum Plus Pemetrexed (with and Without Bevacizumab) in Patients with Unresectable Malignant Pleural Mesothelioma in Switzerland
Creators: name: Barbier, Michaela Carla
name: Fengler, Alicia
name: Pardo, Esther
name: Bhadhuri, Arjun
name: Meier, Niklaus
name: Gautschi, Oliver
Publisher: name: Springer
Year: 2023

description: Background Malignant pleural mesotheliomas (MPMs) are aggressive and often unresectable. In the past, chemotherapy was the standard for palliative treatment. However, immunotherapy with nivolumab+ipilimumab has recently received marketing approval. Objectives This study evaluated the cost effectiveness of nivolumab+ipilimumab versus pemetrexed+platinum (with/without bevacizumab) for Swiss patients with unresectable MPM, overall and by histological subtype. Methods We developed a three-state Markov cohort model with a cycle length of 1 month, a 30-year time horizon, and a discount rate of 3% per year for costs and benefits. The model included the updated survival and treatment-dependent utility results from the Checkmate-743 and MAPS registration trials. A Swiss statutory health insurance perspective was considered with unit costs for 2022 from publicly available and real-world sources. We assumed a willingness-to-pay (WTP) threshold of CHF100,000/QALY. Model robustness was explored in sensitivity and scenario analyses. Results Compared with chemotherapy, nivolumab+ipilimumab incurred additional costs of CHF109,115 and 0.57 additional quality-adjusted life-years (QALYs), yielding an incremental cost-effectiveness ratio (ICER) of CHF192,585/QALY (i.e. USD201,829/QALY) gained. Relative to their 2022 list price, nivolumab+ipilimumab may be cost effective if priced at 48% across all histologies. Assuming cisplatin-based instead of carboplatin-based chemotherapy reduced the ICER to CHF158,911/QALY (i.e. USD166,539/QALY). For the non-epithelioid subtype, nivolumab+ipilimumab was cost effective compared with chemotherapy (ICER of CHF97,894/QALY, i.e. USD102,593/QALY). Chemotherapy+bevacizumab was often a dominated strategy or would require a bevacizumab cost reduction to 28%. Conclusions Our model projected nivolumab+ipilimumab to be cost effective for the non-epithelioid subtype but not for all histologies. Substantial discounts for nivolumab+ipilimumab would be necessary to achieve cost effectiveness for all histologies.
Bathynomus undetermined
Creators: name: Huang, Ming-Chih
name: Kawai, Tadashi
name: Bruce, Niel L.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Cirolanidae
Bathynomus
Bathynomus undetermined

description: Bathynomus sp.
Material
TMCD 003326 and TMCD 003334
One ovigerous female, collected by bottom trawl in the northern South China Sea between North Vereker Bank (221.061°N, 116.109°E) and Pratas Island (20.717°N, 116.700°E) by the crew of Keelung-based fishing vessel Jin Ruiyi 37 on 17 June 2019 (Figure 1) voucher numbers TMCD003326. One male, captured in waters of the South China Sea (19.084°N, 115.250°E) by the crew of Keelung-based fishing vessel Jing yang on 12 May 2020; the water depth was about 420–550 m, TMCD003334. TL 309 and 356 mm, CL 150 and 173 mm, wet weight 1100 and 1600 g, respectively (Table 1).
Remarks
Two apparently sympatric species of Bathynomus are present in the material examined. Both of these had been identified as Bathynomus jamesi (Kou, Chen and Li, 2017); that identification was confirmed by COI data (NCBI Acc. No. MW575424 and MW577652).
The second apparent species, while having the same clypeus and pleonite characters as B. jamesi, differs from B. jamesi s. str. in a number of significant characters (state of B. jamesi in parentheses): the body is slender, with the pereon lateral margins relatively straight (vs convex); the pleotelson is 0.70 times as long as wide (vs 0.42–0.56); the pleotelson spines are flat and proximally broad (vs round, proximally narrow). These morphological character differences would be considered indicative of a separate species, but at present we are unable to discern further differentiating characters. Furthermore, COI data indicates that this material is conspecific with the South China Sea material identified as B. jamesi. At present we regard the identity of these specimens as inconclusive, and prefer to exclude the material from B. jamesi until further specimens are available to either evaluate variation within B. jamesi or confirm that the material represents a distinct species.
description: Published as part of Huang, Ming-Chih, Kawai, Tadashi & Bruce, Niel L., 2022, A new species of Bathynomus Milne-Edwards, 1879 (Isopoda: Cirolanidae) from the southern Gulf of Mexico with a redescription of Bathynomus jamesi Kou, Chen and Li, 2017 from off Pratas Island, Taiwan, pp. 885-921 in Journal of Natural History 56 (13 - 16) on pages 902-903, DOI: 10.1080/00222933.2022.2086835, http://zenodo.org/record/7012152
title: Epistemic paternalism and political normative epistemology
Creators: name: Pang, Jeanne To Man
Year: 2024

description: Diese Masterarbeit argumentiert, dass epistemischer Paternalismus ein Instrument epistemischer Interventionen sein kann, die sowohl epistemische als auch nicht-epistemische Unterdrückungen bekämpfen können. Die Masterarbeit basiert auf Konzepten wie epistemischen Werten, (epistemischer) Autonomie und ihrem Verhältnis zu unserem Handlungsspielraum. Wir müssen den sozialen und interaktiven Charakter unserer epistemischen Handlungsfähigkeit (epistemic agency) anerkennen, um zu verstehen, wie sie gedeiht oder verkümmert, und dadurch zu erfassen, was epistemisch wertvoll für uns ist. Damit epistemischer Paternalismus wirksam sein kann, muss er auf dem Verständnis beruhen, dass sowohl epistemische als auch nicht-epistemische Unterdrückungen unser epistemisches Wirken beeinflussen. Er muss auch der Ansicht verpflichtet sein, dass wir aktiv danach streben, diese Unterdrückungen zu mindern oder zu beseitigen, da sie unsere epistemische Entfaltung behindert, andernfalls besteht die Gefahr, Unterdrückungen zu verstärken. Um dieses Projekt zu veranschaulichen, befasst sich diese Arbeit auch mit bestehenden Debatten rund um den epistemischen Paternalismus, einschließlich des Paternalismus des epistemischen Zugangs (epistemic access paternalism) und des epistemischen Nudgings. Die Untersuchung grundlegender Konzepte und Annahmen, die in diesen Debatten eine Rolle spielen, hilft zu klären, worum es bei epistemischen Interventionen geht, sowie um ein Modell zu entwickeln, das unser beeinträchtigtes epistemisches Wirken berücksichtigt. Schließlich wird ein Fallbeispiel einer epistemisch paternalistischen Handlung diskutiert: die Verwendung des Pluralspronomen ,,they'' als Singular im Englischen.
description: This thesis argues that epistemic paternalism can be a tool of providing epistemic interventions that address both epistemic and non-epistemic oppressions. This thesis is based on concepts such as epistemic values, (epistemic) autonomy, and their relation to our agency. We must recognise the social and interactive character of our epistemic agency to understand how it flourishes and shrinks, and thus to be able to account for what is epistemically valuable for us. For epistemic paternalism to be effective, it must be grounded in an understanding of how both epistemic and non-epistemic oppressions affect our epistemic agency. It must also be committed to the view that we actively strive to mitigate or undermine these oppressions as they hinder our epistemic flourishing, or else we risk perpetuating them. To illustrate this project, this thesis also engages with existing debates surrounding epistemic paternalism, including Epistemic Access Paternalism and Epistemic Nudging. Exploring core conceptions and assumptions involved in these debates helps to clarify what epistemic interventions involve and to develop an account that addresses our compromised epistemic agency. Finally, one example case of an act of epistemic paternalism is discussed, the use of singular "they" in English.
Additional file 1: of Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models
Creators: name: E. López De Maturana
name: A. Picornell
name: A. Masson-Lecomte
name: M. Kogevinas
name: M. Márquez
name: A. Carrato
name: A. Tardón
name: J. Lloreta
name: M. García-Closas
name: D. Silverman
name: N. Rothman
name: S. Chanock
name: F. Real
name: M. Goddard
name: N. Malats
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics
subject: Hematology
subject: 60506 Virology

description: Table S1. Clinico-pathological variables included in the predictive models for time to first recurrence (TFR) and time to progression (TP). Table S2. Summary of censored patients and events (%) for each event in each time interval defined for the statistical analyses. Table S3. Area under the ROC curve (AUC) and coefficient of determination (R probit 2 ) obtained for each testing set in the 10 fold-crossvalidation analyses of time to first recurrence. Table S4. Area under the ROC curve (AUC) and coefficient of determination (R probit 2 ) obtained for each testing set in the 10 fold-crossvalidation analyses of time to progression. Table S5. Area under the ROC curve (AUC) and coefficient of determination (R probit 2 ) obtained for each testing set in the 2 fold-crossvalidation analyses of time to progression in patients at high risk. Table S6. Area under the ROC curve (AUC) and coefficient of determination (R probit 2 ) obtained for each testing set in the 2 fold-crossvalidation analyses of time to progression in patients at low risk. Table S7. Coefficient of determination (R probit 2 ) obtained for each testing set in the 10 fold-crossvalidation analyses of time to first recurrence (TFR), time to progression (TP) in the whole cohort, and time to progression (TP) in the high and low risk cohorts (TPHiR and TPLR). (DOC 113 kb)
DECIPHERING CANCER CELL METABOLISM: IMPLICATIONS  FOR TARGETED THERAPIES
Creators: name: Kethiswar Raj Rajendran
name: Vinodhini Priyanka Radhakrishnan
name: Murugesan K
Publisher: name: Zenodo
Year: 2024
Subjects: Cancer Angiogenesis, Metabolomic Reprogramming, Cancer Cell Metabolism, Warburg Effect, Synergistic Effects

description: Abstract

Understanding the intricate metabolic alterations in cancer cells is crucial for the development of effective targeted therapies. Cancer cell metabolism is characterized by rewired pathways that support rapid proliferation, survival, and metastasis. The Warburg effect, a hallmark of cancer metabolism, involves increased aerobic glycolysis even in the presence of oxygen, leading to elevated glucose uptake and lactate production. Beyond glycolysis, cancer cells exhibit alterations in glutamine metabolism, lipid synthesis, and amino acid metabolism to meet their energy and biosynthetic demands. Deciphering these metabolic adaptations offers insights into the vulnerabilities of cancer cells and the potential for targeted intervention. Targeting key metabolic enzymes and pathways has emerged as a promising strategy in cancer therapy. Small molecule inhibitors targeting glycolytic enzymes, such as hexokinase and pyruvate kinase, have shown efficacy in preclinical models and early-phase clinical trials. Similarly, inhibitors of glutamine metabolism, such as glutaminase inhibitors, disrupt cancer cell proliferation and survival. Moreover, the development of combination therapies targeting multiple metabolic pathways offers synergistic effects and improved treatment outcomes. Integration of metabolomic data, imaging techniques, and computational modeling enables the identification of metabolic signatures, predictive biomarkers, and personalized treatment strategies. Additionally, metabolic targeting holds promise for overcoming therapeutic resistance and enhancing the efficacy of current cancer therapies. In conclusion, deciphering cancer cell metabolism provides valuable insights into the molecular mechanisms driving tumorigenesis and informs the development of targeted therapies tailored to the metabolic vulnerabilities of cancer cells. By exploiting these metabolic dependencies, researchers aim to improve patient outcomes and advance precision medicine approaches in cancer therapy.
Additional file 1: Table S1. of Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD
Creators: name: Calverley, Peter
name: Rennard, Stephen
name: Clerisme-Beaty, Emmanuelle
name: Metzdorf, Norbert
name: Zubek, Valentina
name: ZuWallack, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Energy and fatigue questionnaire. Patients were asked to choose one option in each question that best described how they felt. (PDF 12Â kb)
Additional file 3 of Integrated single cell data analysis reveals cell specific networks and novel coactivation markers
Creators: name: Ghazanfar, Shila
name: Bisogni, Adam
name: Ormerod, John
name: Lin, David
name: Yang, Jean
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Figure S3. Scatterplot of number of olfactory genes with non-zero values against number of olfactory genes classified as active (highly expressed). The gray solid line is the diagonal line and other dotted lines are fitted lines for each dataset. (PDF 225 KB)
Additional file 2: of Adverse pregnancy outcomes in rural Uganda (1996–2013): trends and associated factors from serial cross sectional surveys
Creators: name: Gershim Asiki
name: Baisley, Kathy
name: Newton, Rob
name: Marions, Lena
name: Seeley, Janet
name: Kamali, Anatoli
name: Smedman, Lars
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Factors associated with abortion, among 2557 women aged 15–49 years reporting a pregnancy in the past 12 months (1996–2013). (DOCX 17 kb)
Französische Fagottlehrwerke des 19. Jahrhunderts aus der Sicht der heutigen Instrumentalpädagogik
Creators: name: Kilchenmann, Marc
Publisher: name: Edition Argus
Year: 2017

description: Solistische Literatur für Fagott aus dem 19. Jahrhundert ist selten. Zwar bedienten sich die Komponisten gerne des Fagotts als Orchesterinstrument, aber nach Carl Maria von Webers Fagottkonzert op. 75 sind bedeutende Beiträge zur Sololiteratur rar geworden. Die Fagottkonzerte von Franz Berwald, Bernhard Crusell oder das jüngst gefundene, Gioachino Rossini zugeschriebene Werk sind aber aufgrund ihres großen Schwierigkeitsgrads im Unterricht kaum zu verwenden. Das Teilprojekt »Französische Fagottlehrwerke des 19. Jahrhunderts aus Sicht der heutigen Instrumentalpädagogik« im Rahmen des vom Schweizerischen Nationalfonds (dore) geförderten Forschungsvorhabens »Le basson Savary« hatte sich deshalb zum Ziel gesetzt, die französische Unterrichtsliteratur aus der Zeit von Jean-Nicolas Savary le jeune für den heutigen Instrumentalunterricht nutzbar zu machen.1 Als besonders lohnend erwiesen sich dabei die Bearbeitungen in ihrer Zeit populärer Opernarien und Melodien, denn Frédéric Berr, Friedrich Blumer und Eugène Jancourt verfassten eine Vielzahl auch für den heutigen Unterricht geeigneter Stücke.