cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Leucothoe occidentalis
Creators: name: White, Kristine N.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ericaceae
Leucothoe
Leucothoe occidentalis

description: Leucothoe occidentalis (Reid, 1951)
 L. spinicarpa var. occidentalis Reid, 1951: 225, 226, fig. 24.
 L. spinicarpa Serejo, 1998: 108, 109, figs 1, 2.
 L. occidentalis Krapp-Shickel & Menioui, 2005: 71, 72, fig. 6.
 Type locality and specimens. Tropical West Africa, 9°30'N 14– 15°W. Males and females, 4–5 mm.
 Material examined. No material available for examination. Diagnosis based on description by Reid (1951) and Krapp-Schickel & Menioui (2005).
 Diagnosis. Gnathopod 1 basis with facial setae. Gnathopod 2 carpus distally truncate; propodus mediofacial setal row displaced to midline. Epimeron 1 with anteroventral tuft of setae. Uropod 3 peduncle elongate. Telson apex with a strong point. Red banding on the body with black eyes.
 Female (sexually dimorphic characters). Without red bands on body, pink eyes.
 Habitat. Among sand, sponges and corals; 0–30 m.
 Host. Unknown.
 Distribution. Atlantic Ocean: West Africa (Reid 1951), Brazil (Serejo 1998), Morocco (Krapp-Schickel & Menioui 2005).
description: Published as part of White, Kristine N., 2011, A taxonomic review of the Leucothoidae (Crustacea: Amphipoda) 3078, pp. 1-113 in Zootaxa 3078 (1) on page 63, DOI: 10.11646/zootaxa.3078.1.1, http://zenodo.org/record/5243821
Functionalisation of a heat-derived and bio-inert albumin hydrogel with extracellular matrix by air plasma treatment
Creators: name: Ong, John
name: Zhao, Junzhe
name: Levy, Galit Katarivas
name: Macdonald, James
name: Justin, Alexander W.
name: Markaki, Athina E.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/45
/631/1647
/631/61
/639/638
/639/301
article

description: Funder: Cambridge Commonwealth, European and International Trust; doi: https://doi.org/10.13039/501100003343
description: Funder: Trinity College, University of Cambridge; doi: https://doi.org/10.13039/501100000727
description: Funder: Blavatnik Family Foundation; doi: https://doi.org/10.13039/100011643
description: Funder: Reuben Foundation
description: Funder: Worshipful Council of Engineers
description: Funder: Isaac Newton Trust; doi: https://doi.org/10.13039/501100004815
description: Abstract: Albumin-based hydrogels are increasingly attractive in tissue engineering because they provide a xeno-free, biocompatible and potentially patient-specific platform for tissue engineering and drug delivery. The majority of research on albumin hydrogels has focused on bovine serum albumin (BSA), leaving human serum albumin (HSA) comparatively understudied. Different gelation methods are usually employed for HSA and BSA, and variations in the amino acid sequences of HSA and BSA exist; these account for differences in the hydrogel properties. Heat-induced gelation of aqueous HSA is the easiest method of synthesizing HSA hydrogels however hydrogel opacity and poor cell attachment limit their usefulness in downstream applications. Here, a solution to this problem is presented. Stable and translucent HSA hydrogels were created by controlled thermal gelation and the addition of sodium chloride. The resulting bio-inert hydrogel was then subjected to air plasma treatment which functionalised its surface, enabling the attachment of basement membrane matrix (Geltrex). In vitro survival and proliferation studies of foetal human osteoblasts subsequently demonstrated good biocompatibility of functionalised albumin hydrogels compared to untreated samples. Thus, air plasma treatment enables functionalisation of inert heat-derived HSA hydrogels with extracellular matrix proteins and these may be used as a xeno-free platform for biomedical research or cell therapy.
Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression with Alopecia Areata in Males: A Case–control Study
Creators: name: Toraih, Eman A.
name: Ameen, Hatem M
name: Hussein, Mohammad H.
name: Elabd, Ahmed A. Youssef
name: Mohamed, Abeer M.
name: Abdelhady Ragab Abdel-Gawad
name: Fawzy, Manal S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Alopecia areata (AA) is a non-scarring hair loss of autoimmune etiology. The autoimmune regulator (AIRE) gene is believed to be an important driver in AA pathogenesis. Genetic variants can alter mRNA expression levels which may provoke an autoimmune response. A total of 337 males (97 AA patients and 240 controls) were enrolled in the current case–control study. On screening of the most frequent variants in the gene, rs2075876 (A/G) polymorphism in intron 5 was selected and genotyped using Real-Time PCR (polymerase chain reaction) technology. Additionally, circulatory AIRE expression levels were quantified by quantitative reverse-transcription PCR (qRT-PCR). Allelic discrimination analysis revealed GG genotype to be more frequent in patients (90.7% in AA compared to 32.5% in controls, p < .001). G variant conferred increased risk to alopecia under homozygote comparison (GG versus AA: OR = 16.1, 95%CI = 5.57–46.3), dominant model (GG+AG versus AA: OR = 7.24, 95%CI = 2.5–20.5), recessive model (GG versus AG+AA: OR = 20.3, 95%CI = 9.7–42.4), and allelic model (G versus A: OR = 11.6, 95%CI = 6.47–21.1). The expression levels of AIRE gene did not differ significantly between patients and controls and were not related to rs2075876 variant. In conclusion, the intronic variant (rs2075876) is suggested to be a potent susceptibility variant for AA development in the studied population. Abbreviations: AA: Alopecia areata; AIRE: Autoimmune Regulator; APECED: Autoimmune, Polyendocrinopathy Candidiasis Ectodermal Dystrophy; DLQI: Dermatology life quality index questionnaire; MIQE: Minimum information for publication of quantitative real-time PCR experiments; mTEC: Medullary thymic epithelial cells; PHD: Plant homeodomain; qRT-PCR: Quantitative reversetranscription-polymerase chain reaction; RA: Rheumatoid arthritis
Additional file 5 of LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Creators: name: Zhao, Peng
name: Xu, Yuanzhong
name: Jiang, Lu-Lin
name: Fan, Xuejun
name: Ku, Zhiqiang
name: Li, Leike
name: Liu, Xiaoye
name: Deng, Mi
name: Arase, Hisashi
name: Zhu, Jay-Jiguang
name: Huang, Timothy Y.
name: Zhao, Yingjun
name: Zhang, Chengcheng
name: Xu, Huaxi
name: Tong, Qingchun
name: Zhang, Ningyan
name: An, Zhiqiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 5: Supplementary Figure 5. Ab29 increases microglial responses to amyloid plaques in vivo. a. Representative amyloid plaque-microglia co-localization immunofluorescence staining of 5-month-old 5XFAD mice cortex as treated in Fig. 6a. Scale bar = 20 μm. IBA1, microglia marker; 6E10, amyloid plaque marker. b. Quantification of IBA1 area within 30 μm of amyloid plaques in the cortex of mice treated as described in Fig. 6a. n = 5 independent mice. c. Representative amyloid plaque-CD68 co-localization immunofluorescence staining of the cortex of 5XFAD mice treated as described in Fig. 6a. CD68, microglia phagocytic marker. Scale bar = 20 μm. d. Quantification of CD68 area within 30 μm of amyloid plaques in the cortex of mice treated as described in Fig. 6a. n = 5 independent mice. e. Quantification of Aβ co-localized with CD68 per plaque in the cortex of mice treated as described in Fig. 6a. n = 5 independent mice. For all the data presented, bar graphs with error bars represent mean ± SD. For the statistical analysis, *** P < 0.001, two-tailed Student t-test.
A SYSTEMATIC REVIEW AND META-ANALYSIS OF PLAYING-RELATED MUSCULOSKELETAL DISORDERS IN MUSICIANS RELATING TO BIOLOGICAL SEX AND INSTRUMENT PLAYED
Creators: name: Coley, Katherine M.
name: Widmer, Abigail G.
name: Dapkus, Katherine M.
name: Kapoor, Divya S.
name: Murphy, Lucas J.
name: Patriarca, Laura E.
name: Rhee, Hannah J.
name: Solomon, Julianna A.
name: Waugh, Lauren J.
name: Bell, Elizabeth
Publisher: name: Digital Repository at the University of Maryland
Year: 2021
Subjects: Gemstone Team METR

description: Gemstone Team METR
description: Playing-related musculoskeletal disorders (PRMDs) are occupational health concerns that cause pain, discomfort, or disability for musicians. We utilized a systematic review and meta-analysis to analyze disparities in prevalence based on sex and instrument, and assess whether instrument choice was associated with sex-based prevalence disparities. Six databases were searched for studies containing prevalence rates for males or females, or specific instruments. Studies were evaluated for methodological quality and data was statistically evaluated in a meta-analysis. Our initial search yielded 5961 articles, of which 23 articles met quality assessment criteria and were included in quantitative analyses. Sex-based disparities were observed such that being female increased one’s odds of having a PRMD by 88% when compared to males. Limited available studies with relevant data prevented analysis of the interaction between instrument and sex.
Households Demand for Staple Cereal Commodities in Burkina Faso
Creators: name: Traore, Togo M.
name: Fields, Deacue
name: Traore, Togo M.
name: Fields, Deacue
Publisher: name: Unknown
Year: 2016
Subjects: subject: Consumer/Household Economics
subject: Demand and Price Analysis
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: AIDS model
subject: staple cereals demand
subject: consumption patterns
subject: Burkina Faso.

description: With a population increasing rapidly and agricultural yields stagnant over the years, access to food is a major challenge in Burkina Faso. This study investigates households demand for staple cereal commodities in Burkina Faso, using data from the 2009/10 integrated household living condition survey. A complete demand system (AIDS) model is estimated taking into account demographics and zero consumption. Results show that maize, millet and sorghum are necessities while rice is considered a luxury. Demand for maize, millet and sorghum are less price elastic than rice. These results are consistent for most households except for wealthy, educated households living in urban areas where rice becomes a necessity. The analysis of the evolution of cereal prices shows an overall increase leaving many people in food insecurity and causing food riots.
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Creators: name: Maes, Mailis
name: Dyson, Zoe A.
name: Smith, Sarah E.
name: Goulding, David A.
name: Ludden, Catherine
name: Baker, Stephen
name: Kellam, Paul
name: Reece, Stephen T.
name: Dougan, Gordon
name: Scott, Josefin Bartholdson
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/326/41
/631/326/421
/631/154/51/1568
/631/154/1435/2163
/631/154/1435/2417
/631/326
/631/326/22/1434
article

description: Funder: National Institute for Health Research; doi: http://dx.doi.org/10.13039/501100000272
description: Funder: MRC Proximity to Discovery: Industry Engagement Fund Biomedical Research Exchange Programme
description: Abstract: The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated anti-bacterial efficacy of a humanised monoclonal antibody (mAb) targeting the O25b O-antigen of Escherichia coli ST131. To evaluate the phenotypic effects of antibody binding to diverse clinical E. coli ST131 O25b bacterial isolates in high-throughput, we designed a novel mAb screening method using high-content imaging (HCI) and image-based morphological profiling to screen a mAb targeting the O25b O-antigen. Screening the antibody against a panel of 86 clinical E. coli ST131 O25:H4 isolates revealed 4 binding phenotypes: no binding (18.60%), weak binding (4.65%), strong binding (69.77%) and strong agglutinating binding (6.98%). Impaired antibody binding could be explained by the presence of insertion sequences or mutations in O-antigen or lipopolysaccharide core biosynthesis genes, affecting the amount, structure or chain length of the O-antigen. The agglutinating binding phenotype was linked with lower O-antigen density, enhanced antibody-mediated phagocytosis and increased serum susceptibly. This study highlights the need to screen candidate mAbs against large panels of clinically relevant isolates, and that HCI can be used to evaluate mAb binding affinity and potential functional efficacy against AMR bacteria.
$B^*_s\rightarrow l^+l^-$ decays in light of recent $B$ anomalies
Creators: name: Kumbhakar, Suman
name: Saini, Jyoti
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Some of the recent measurements in the neutral current sector $b\rightarrow s l^+l^-$ ($l=e$ or $μ$) as well as in the charged current sector $b \rightarrow c τ\barν$ show significant deviations from their Standard Model predictions. It has been shown that two different new physics solutions, in the form of vector and/or axial vector, can explain all the anomalies in $b\rightarrow s l^+l^-$ sector. We show that the muon longitudinal polarization asymmetry in $B^*_s\rightarrow μ^+\,μ^-$ decay is a good discriminant between the two solutions if it can be measured to a precision of $\sim 10\%$, provided the new physics Wilson coefficients are real. We also investigate the potential impact of $b \rightarrow c τ\barν$ anomalies on $B_s^* \rightarrow τ^+ τ^-$ decay. We consider a model where the new physics contributions to these two transitions are strongly correlated. We find that two orders of magnitude enhancement in the branching ratio of $B^*_s\rightarrow τ^+\,τ^-$ is allowed by the present $b \rightarrow c τ\barν$ data.
description: 6 pages, 1 figure, Contribution to proceedings of XXIII DAE-BRNS HEP Symposium 2018, Dec. 10-14, 2018, Chennai, India
Supersymmetry Changing Bubbles in String Theory
Creators: name: Kachru, S.
name: Liu, X.
name: Schulz, M.
name: Trivedi, S. P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We give examples of string compactifications to 4d Minkowski space with different amounts of supersymmetry that can be connected by spherical domain walls. The tension of these domain walls is tunably lower than the 4d Planck scale. The ``stringy'' description of these walls is known in terms of certain configurations of wrapped Dirichlet and NS branes. This construction allows us to connect a variety of vacua with 4d N=4,3,2,1 supersymmetry.
description: 11 pages, harvmac, no figures, reference added, minor corrections
ОЦЕНКА ЭФФЕКТИВНОСТИ ЭКСИМЕРНЫЙ ЛАЗЕР  У БОЛЬНЫХ С ХРОНИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ С ДИАГНОЗОМ АЛОПЕЦИЯ.
Creators: name: Юсупов, Дилшод
Publisher: name: Zenodo
Year: 2025

description: в данной статье приведены результаты оценки эффективности эксимерный лазер  у 38 пациентов с диагнозом алопеция, находившихся на лечении в областном отделении РИД и КИАТМ Бухарской области. Цель исследования, определение изменений у больных с диагнозом алопеция с помощью комплексных методов обследования и, соответственно, дальнейшая оптимизация комплексных методов лечения.
EFFICIENCY EVALUATION OF RICE PRODUCTION IN BANGLADESH
Creators: name: Regmi, Madhav
name: Oladipo, Obembe
name: Jason, Bergtold
name: Regmi, Madhav
name: Oladipo, Obembe
name: Jason, Bergtold
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: International Development
subject: Production Economics
subject: Productivity Analysis
subject: Rice
subject: Technical Efficiency
subject: Cost Efficiency
subject: Allocative Efficiency
subject: DEA
subject: Tobit
subject: Bangladesh

description: The purpose of this paper is to compare and explain the production efficiencies across rice varieties grown in Bangladesh. Specifically, this study compares the efficiencies among three main rice varieties (Local Aman, HYV Aman and HYV Boro), between two monsoon season varieties (Local Aman and HYV Aman), and between high yielding varieties of monsoon (HYV Aman ) and dry season (HYV Boro) across the seven administrative divisions of Bangladesh. Result indicates that HYV Boro is more efficient (technical, cost and allocative) among all three main rice varieties in Bangladesh. HYV Aman is more efficient than Local Aman in all seven divisions and HYV Boro is more efficient than HYV Aman across all divisions except Sylhet. Several determinants of these efficiency scores were identified using the Tobit regression. The coefficient estimates suggest that off-farm activities of households, loan status, farm subsidies, extension services, household head characteristics (age, literacy, gender and occupation), and dependency ratio of households are the key explanatory variables of these efficiency scores.
Clean, Robust Alkali Sources by Intercalation within Highly-Oriented Pyrolytic Graphite
Creators: name: Kohn, Rudolph N.
name: Bigelow, Matthew S.
name: Spanjers, Mary
name: Stuhl, Benjamin K.
name: Kasch, Brian L.
name: Olson, Spencer E.
name: Imhof, Eric A.
name: Hostutler, David A.
name: Squires, Matthew B.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report the fabrication, characterization, and use of rubidium vapor dispensers based on highly-oriented pyrolytic graphite (HOPG) intercalated with metallic rubidium. Compared to commercial chromate salt dispensers, these intercalated HOPG (IHOPG) dispensers hold an order of magnitude more rubidium in a similar volume, require less than one-fourth the heating power, and emit less than one-half as many impurities. Appropriate processing permits exposure of the IHOPG to atmosphere for over ninety minutes without any adverse effects. Intercalation of cesium and potassium into HOPG have also been demonstrated in the literature, which suggests that IHOPG dispensers may also be be made for those metals.
description: 20 pages, 6 figures. The following article has been accepted by Review of Scientific Instruments. After it is published, it will be found at http://dx.doi.org/10.1063/1.5128120
Additional file 1 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Creators: name: Liu, Huan
name: Wang, Qiyu
name: Wang, Jinglong
name: Liu, Yunfei
name: Renzeng, Wangdui
name: Zhao, Guiqin
name: Niu, Kuiju
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Gene ID and sequences of primers.
Need for Critical Cyber Defence, Security Strategy and Privacy Policy in Bangladesh - Hype or Reality?
Creators: name: Haque, AKM Bahalul
Publisher: name: arXiv
Year: 2019
Subjects: subject: Social and Information Networks (cs.SI)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Cyber security is one of the burning issues in modern world. Increased IT infrastructure has given rise to enormous chances of security breach. Bangladesh being a relatively new member of cyber security arena has its own demand and appeal. Digitalization is happening in Bangladesh for last few years at an appreciable rate. People are being connected to the worldwide web community with their smart devices. These devices have their own vulnerability issues as well as the data shared over the internet has a very good chances of getting breached. Common vulnerability issues like infecting the device with malware, Trojan, virus are on the rise. Moreover, a lack of proper cyber security policy and strategy might make the existing situation at the vulnerable edge of tipping point. Hence the upcoming new infrastructures will be at a greater risk if the issues are not dealt with at an early age. In this paper common vulnerability issues including their recent attacks on cyber space of Bangladesh, cyber security strategy and need for data privacy policy is discussed and analysed briefly.
description: 14 Pages, 8 Figures , 1 Table
Willingness to donate genomic and other medical data: results from Germany
Creators: name: Voigt, Torsten H.
name: Holtz, Verena
name: Niemiec, Emilia
name: Howard, Heidi C.
name: Middleton, Anna
name: Prainsack, Barbara
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/706/689/179
/631/208
article

description: Abstract: This paper reports findings from Germany-based participants in the “Your DNA, Your Say” study, a collaborative effort among researchers in more than 20 countries across the world to explore public attitudes, values and opinions towards willingness to donate genomic and other personal data for use by others. Based on a representative sample of German residents (n = 1506) who completed the German-language version of the survey, we found that views of genetic exceptionalism were less prevalent in the German-language arm of the study than in the English-language arm (43% versus 52%). Also, people’s willingness to make their data available for research was lower in the German than in the English-language samples of the study (56% versus 67%). In the German sample, those who were more familiar with genetics, and those holding views of genetic exceptionalism were more likely to be willing to donate data than others. We explain these findings with reference to the important role that the “right of informational self-determination” plays in German public discourse. Rather than being a particularly strict interpretation of privacy in the sense of a right to be left alone, the German understanding of informational self-determination bestows on each citizen the responsibility to carefully consider how their personal data should be used to protect important rights and to serve the public good.
The 2010-2011 Drought Impacts on Cattle Market Integration in the Horn of Africa: A preliminary Evaluation using VAR and Structural Break Analysis
Creators: name: Bizimana, Jean-Claude
name: Bessler, David A.
name: Angerer, Jay P.
name: Bizimana, Jean-Claude
name: Bessler, David A.
name: Angerer, Jay P.
Publisher: name: Unknown
Year: 2016
Subjects: subject: Food Security and Poverty
subject: International Development
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: livestock
subject: drought
subject: market integration vector auto-regression
subject: directed acyclic graph
subject: structural break

description: Livestock rearing is an important risk reduction strategy for vulnerable communities in developing countries and a major provider of nutrients and traction for crop production. However there is a great concern for pastoral population in the arid and semi-arid zones of East Africa due to recurring drought. Drought leads to the decline in forage and water availability which in return deteriorates the overall livestock health and reduces livestock prices and revenues. This study analyzes the level of price interaction among livestock markets in Ethiopia and Kenya and the impact of the 2010-2011’s drought on cattle prices using time series analysis. The results on cattle price dynamics show limited interaction among cattle markets in both countries. The structural break analysis indicates the period around 2010-2011 as a predominant break date for the markets in Ethiopia and Kenya. A lack of market integration in addition to drought prevent cattle herders from using markets as a mitigating mechanism against drought, by selling livestock to destock during drought and buying livestock to restock after drought. In brief, a high level of livestock markets integration can lower the risk of losing animals during a drought.
Two-bag intravenous N-acetylcysteine, antihistamine pretreatment and high plasma paracetamol levels are associated with a lower incidence of anaphylactoid reactions to N-acetylcysteine
Creators: name: Daoud, Alaa
name: Dalhoff, Kim Peder
name: Christensen, Mikkel Bring
name: Bøgevig, Søren
name: Petersen, Tonny Studsgaard
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Context:N-acetylcysteine (NAC) is used worldwide to prevent liver injury after paracetamol overdoses. Anaphylactoid reactions to NAC occur frequently and often lead to treatment interruptions or discontinuations. In Denmark in 2013, the NAC treatment regimen was simplified from a three-bag to a two-bag NAC regimen. Factors of importance for the development of anaphylactoid reaction to this new regimen are poorly explored. Previous studies have suggested a protective effect of high plasma levels of paracetamol on the development of anaphylactoid reactions. Likewise, exposure to antihistamines prior to NAC treatment may protect against these reactions. Methods: This is a retrospective cohort study of patients treated with NAC and with at least one plasma paracetamol sample performed in the Capital Region of Denmark from 2010 to 2017. The primary outcome was the incidence of anaphylactoid reactions to NAC requiring intravenous treatment with antihistamines and/or glucocorticoids. Logistic regression analyses were carried out to identify the risk of developing an anaphylactoid reaction to NAC affected by influencing factors. Results: Of 4315 admissions included in the study, 259 (6.0%) developed an anaphylactoid reaction to NAC. The two-bag regimen (adjusted OR 0.44 [95%CI: 0.32–0.60]), increasing age (adjusted OR 0.84 [95%CI: 0.78–0.90] per 10-year increase) or children <10 years (adjusted OR 0.14 [95%CI: 0.04–0.36]) and antihistamine co-ingestion in overdose (adjusted OR 0.17 [95%CI: 0.02–0.64]) were associated with significantly fewer anaphylactoid reactions. High plasma paracetamol concentrations protected against development of anaphylactoid reactions during the two-bag regimen (adjusted OR 0.59 [95%CI: 0.47–0.71] and three-bag regimen 0.82 [95%CI: 0.72–0.94] per doubling of paracetamol concentration). The effect differed between the two regimens (p = .004 for interaction). Conclusion: In this retrospective cohort, a high peak plasma paracetamol concentration, age, antihistamine co-ingestion and use of the two-bag NAC regimen were associated with fewer anaphylactoid reactions to NAC.
Leucothoe orkneyi Holman & Watling 1983
Creators: name: White, Kristine N.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ericaceae
Leucothoe
Leucothoe orkneyi

description: Leucothoe orkneyi Holman & Watling, 1983
 Leucothoe orkneyi Holman & Watling, 1983: 231–233, figs 12–14.
 Type locality and specimens. Southern Ocean, South Orkney Islands, 61°26'–25' S 41°055'W. Holotype, male, 9.0 mm; paratypes, male and female, 4.5–9 mm.
 Material examined. No material available for examination. Diagnosis based on description by Holman & Watling (1983).
 Diagnosis. Ventral keel anterior margin excavate; anteroventral corner with projection. Maxilla 1 palp constricted. Maxilliped outer plate tuberculate. Gnathopod 1 carpus and propodus narrow; dactylus short. Gnathopod 2 carpus short with large subdistal tooth; dactylus geniculate. Coxa 6 with facial setae. Pereopods 5–7 bases narrowly expanded. Epimeron 3 posteroventral corner produced.
 Female (sexually dimorphic characters). No significant sexually dimorphic character.
 Habitat. Habitat not reported; 593–604 m.
 Host. Unknown.
 Distribution. Southern Ocean: South Orkney Islands (Holman & Watling 1983).
description: Published as part of White, Kristine N., 2011, A taxonomic review of the Leucothoidae (Crustacea: Amphipoda) 3078, pp. 1-113 in Zootaxa 3078 (1) on page 64, DOI: 10.11646/zootaxa.3078.1.1, http://zenodo.org/record/5243821
Astrophysical Neutrino Event Rates and Sensitivity for Neutrino Telescopes
Creators: name: Albuquerque, Ivone F. M.
name: Lamoureux, Jodi
name: Smoot, George F.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Spectacular processes in astrophysical sites produce high-energy cosmic rays which are further accelerated by Fermi-shocks into a power-law spectrum. These, in passing through radiation fields and matter, produce neutrinos. Neutrino telescopes are designed with large detection volumes to observe such astrophysical sources. A large volume is necessary because the fluxes and cross-sections are small. We estimate various telescopes' sensitivities and expected event rates from astrophysical sources of high-energy neutrinos. We find that an ideal detector of km^2 incident area can be sensitive to a flux of neutrinos integrated over energy from 10^5 and 10^{7} GeV as low as 1.3 * 10^(-8) * E^(-2) (GeV/cm^2 s sr) which is three times smaller than the Waxman-Bachall conservative upper limit on potential neutrino flux. A real detector will have degraded performance. Detection from known point sources is possible but unlikely unless there is prior knowledge of the source location and neutrino arrival time.
description: Section added +modifications
Modeling breast cancer progression to bone: how driver mutation order and metabolism matter
Creators: name: Ascolani, Gianluca
name: Liò, Pietro
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Research
Driver mutations
Metabolic mutations
Mutation order
Breast cancer
Subordinated processes
Non-commuting operators

description: Abstract: Background: Not all the mutations are equally important for the development of metastasis. What about their order? The survival of cancer cells from the primary tumour site to the secondary seeding sites depends on the occurrence of very few driver mutations promoting oncogenic cell behaviours. Usually these driver mutations are among the most effective clinically actionable target markers. The quantitative evaluation of the effects of a mutation across primary and secondary sites is an important challenging problem that can lead to better predictability of cancer progression trajectory. Results: We introduce a quantitative model in the framework of Cellular Automata to investigate the effects of metabolic mutations and mutation order on cancer stemness and tumour cell migration from breast, blood to bone metastasised sites. Our approach models three types of mutations: driver, the order of which is relevant for the dynamics, metabolic which support cancer growth and are estimated from existing databases, and non–driver mutations. We integrate the model with bioinformatics analysis on a cancer mutation database that shows metabolism-modifying alterations constitute an important class of key cancer mutations. Conclusions: Our work provides a quantitative basis of how the order of driver mutations and the number of mutations altering metabolic processis matter for different cancer clones through their progression in breast, blood and bone compartments. This work is innovative because of multi compartment analysis and could impact proliferation of therapy-resistant clonal populations and patient survival. Mathematical modelling of the order of mutations is presented in terms of operators in an accessible way to the broad community of researchers in cancer models so to inspire further developments of this useful (and underused in biomedical models) methodology. We believe our results and the theoretical framework could also suggest experiments to measure the overall personalised cancer mutational signature.
The impacts of anthropogenic sound on marine mammals in the Persian Gulf; current status and need for future research
Creators: name: Sabet, Saeed Shafiei
Publisher: name: figshare
Year: 2021
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Sound-generating human activities so-called "anthropogenic sound" have increased ambient sound levels considerably in aquatic habitats that are markedly diverse in time and space. Sound-generating human activities is now recognized as a potential driver of environmental changes in freshwater and marine habitats. Iran has 750 km coastline along the Caspian Sea located in the north and around 2250 km coastline along the Persian Gulf and the Oman Sea located in the south. However, there is a lack of knowledge concerning whether anthropogenic sound may cause detrimental impacts in migratory and/or endemic marine mammals but also other taxa in the Persian Gulf. Therefore, here I argue that it is necessary to assess natural ambient sound levels but also sound-generating human activities to characterize soundscapes in the Persian Gulf. Moreover, both laboratory and field studies are needed to explore acoustic background and sound impacts on marine mammals and other species. Such knowledge appears to be useful to identify and address the potential impacts of anthropogenic sound and the underlying mechanisms of these impacts on biodiversity in the Persian Gulf.
The Rett Syndrome Gross Motor Scale – Dutch Version (RSGMS-NL) Can Reliably Assess Gross Motor Skills in Dutch Individuals with Rett Syndrome
Creators: name: Borst, Hanneke
name: Weeda, Josianne
name: Downs, Jenny
name: Curfs, Leopold
name: de Bie, Rob
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The Rett Syndrome Gross Motor Scale (RSGMS) is an observational measurement, assessing gross motor skills in individuals with Rett syndrome. A Dutch version is lacking. The current study aims to translate and cross-culturally adapt the original RSMGS to Dutch and assess its inter-rater and intra-rater reliability. Translation and cross-cultural adaptation were performed in concordance with internationally accepted guidelines. A pretest was performed, and expert validation was assured. Video data of three girls with Rett syndrome was independently assessed by 27 physiotherapists via an online webinar to measure inter-rater reliability. Additionally, videos of 17 individuals with Rett syndrome were scored twice by two raters to assess intra-rater reliability. The reliability of the total score, the three subscale scores and the new items were analyzed using Intraclass Correlation Coefficients (ICC). Good comprehensibility and expert validation of the RSMGS-NL was achieved, and four items were added to the original scale. Inter-rater reliability for the total score was excellent (ICC 0.97, 95% CI 0.89–0.99), and good to perfect inter-rater reliability for the three subscales; Sitting, Standing & walking and Challenge was found (ICC values 1.0 (95% CI 0), 0.98 (95% CI 0.91–0.99) and 0.82 (95% CI 0.93–0.99) respectively). The intra-rater reliability was excellent for the total test score (ICC 0.98, 95% CI 0.97–0.99) and good to excellent for the subscale scores (ICC values 0.87 (95% CI 0.75–0.94), 0.99 (95% CI 0.98–1.0) and 0.97 (95% CI 0.95–0.99) respectively). The four new items (Standing to sitting, walking down a slope, ascending the stairs, descending the stairs) showed good to excellent intra-rater reliability. The RSGMS-NL is a reliable measure of gross motor skills in Dutch individuals with Rett syndrome.
Optics robustness of the ATLAS Tile Calorimeter
Creators: name: Pedro, R.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: TileCal, the central hadronic calorimeter of the ATLAS detector is composed of plastic scintillators interleaved by steel plates, and wavelength shifting optical fibres. The optical properties of these components are known to suffer from natural ageing and degrade due to exposure to radiation. The calorimeter was designed for 10 years of LHC operating at the design luminosity of $10^{34}$cm$^{-2}$s$^{-1}$. Irradiation tests of scintillators and fibres have shown that their light yield decrease by about 10% for the maximum dose expected after 10 years of LHC operation. The robustness of the TileCal optics components is evaluated using the calibration systems of the calorimeter: Cs-137 gamma source, laser light, and integrated photomultiplier signals of particles from proton-proton collisions. It is observed that the loss of light yield increases with exposure to radiation as expected. The decrease in the light yield during the years 2015-2017 corresponding to the LHC Run 2 will be reported. The current LHC operation plan foresees a second high luminosity LHC (HL-LHC) phase extending the experiment lifetime for 10 years more. The results obtained in Run 2 indicate that following the light yield response of TileCal is an essential step for predicting the calorimeter performance in future runs. Preliminary studies attempt to extrapolate these measurements to the HL-LHC running conditions.
description: 8 pages, 9 figures, proceedings of CALOR 2018, Eugene, OR, USA, May 2018
Qualität durch Kooperation: UR Library Services
Creators: name: Doß, Brigitte
name: Häusler, Ines
name: Schüller-Zwierlein, André
name: Weisheit, Silke
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Das Datenbank-Infosystem (DBIS), die Elektronische Zeitschriftenbibliothek (EZB) und die Regensburger Verbundklassifikation (RVK) sind seit Jahrzehnten wichtige Services für Bibliotheken und Forschungseinrichtungen und tragende Pfeiler der deutschen und internationalen Informationsinfrastruktur. An der Universitätsbibliothek Regensburg verwurzelt, werden sie durch eine vielfältige und internationale Bibliotheks-Community getragen. EZB und DBIS, entstanden aus Drittmittelprojekten, haben im vergangenen Jahr im Kreise ihrer Anwenderschaft ihr 25- bzw. 20-jähriges Jubiläum gefeiert. Die RVK, die im Jahr 2014 50 Jahre alt wurde, hat sich seitdem zu einer der populärsten Klassifikationen im deutschsprachigen Raum entwickelt.Die drei Services DBIS, EZB und RVK bilden nun die Produktfamilie UR Library Services. Auf der 111.BiblioCON in Hannover fand zum ersten Mal ein gemeinsames Community-Treffen statt. Die Idee dieser Produktfamilie, ihre konkrete Umsetzung und weiterführende Planungen werden im Folgenden erläutert. Zuerst aber werden die drei Services einzeln vorgestellt.
Isostructural Mott transition in 2D honeycomb antiferromagnet V 0.9 PS 3
Creators: name: Coak, Matthew J.
name: Son, Suhan
name: Daisenberger, Dominik
name: Hamidov, Hayrullo
name: Haines, Charles R. S.
name: Alireza, Patricia L.
name: Wildes, Andrew R.
name: Liu, Cheng
name: Saxena, Siddharth S.
name: Park, Je-Geun
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/639/766/119/995
/639/766/119/997
article

description: Abstract: The MPX3 family of magnetic van-der-Waals materials (M denotes a first row transition metal and X either S or Se) are currently the subject of broad and intense attention for low-dimensional magnetism and transport and also for novel device and technological applications, but the vanadium compounds have until this point not been studied beyond their basic properties. We present the observation of an isostructural Mott insulator–metal transition in van-der-Waals honeycomb antiferromagnet V0.9PS3 through high-pressure x-ray diffraction and transport measurements. We observe insulating variable-range-hopping type resistivity in V0.9PS3, with a gradual increase in effective dimensionality with increasing pressure, followed by a transition to a metallic resistivity temperature dependence between 112 and 124 kbar. The metallic state additionally shows a low-temperature upturn we tentatively attribute to the Kondo effect. A gradual structural distortion is seen between 26 and 80 kbar, but no structural change at higher pressures corresponding to the insulator–metal transition. We conclude that the insulator–metal transition occurs in the absence of any distortions to the lattice—an isostructural Mott transition in a new class of two-dimensional material, and in strong contrast to the behavior of the other MPX3 compounds.
Lifetime of short-period binaries measured from their Galactic kinematics
Creators: name: Hwang, Hsiang-Chih
name: Zakamska, Nadia
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: As a significant fraction of stars are in multiple systems, binaries play a crucial role in stellar evolution. Among short-period (<1 day) binary characteristics, age remains one of the most difficult to measure. In this paper, we constrain the lifetime of short-period binaries through their kinematics. With the kinematic information from Gaia Data Release 2 and light curves from {\it Wide-field Infrared Survey Explorer} (WISE), we investigate the eclipsing binary fraction as a function of kinematics for a volume-limited main-sequence sample. We find that the eclipsing binary fraction peaks at a tangential velocity of $10^{1.3-1.6}$ km/s, and decreases towards both low and high velocity end. This implies that thick disk and halo stars have eclipsing binary fraction $\gtrsim 10$ times smaller than the thin-disk stars. This is further supported by the dependence of eclipsing binary fraction on the Galactic latitude. Using Galactic models, we show that our results are inconsistent with any known dependence of binary fraction on metallicity. Instead, our best-fit models suggest that the formation of these short-period binaries is delayed by 0.6-3 Gyr, and the disappearing time is less than the age of the thick disk. The delayed formation time of $\gtrsim0.6$ Gyr implies that these short-period main-sequence binaries cannot be formed by pre-main sequence interaction and the Kozai-Lidov mechanism alone, and suggests that magnetic braking plays a key role in their formation. Because the main-sequence lifetime of our sample is longer than 14 Gyr, if the disappearance of short-period binaries in the old population is due to their finite lifetime, our results imply that most ($\gtrsim90$%) short-period binaries in our sample merge during their main-sequence stage.
description: Accepted for publication in MNRAS. Figure 5 is the key result
Discriminating between effective theories of U_{A}(1) symmetry breaking
Creators: name: Dmitrasinovic, V.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We address the question if one can empirically distinguish between the two proposed solutions to the ``$U_A (1)$ problem'': the 't Hooft, and the Veneziano-Witten $U_{A}(1)$ symmetry breaking effective interactions. Two hadronic observables are offered as discriminants: (1) The scalar ($0^{+}$) meson spectrum; (2) Weinberg's second spectral sum rule. Their present experimental status is discussed.
description: 6 pages, 1 eps file, Yonsei "Hadrons and Nuclei" conference proceedings
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer
Creators: name: Deen, Surrin S.
name: Priest, Andrew N.
name: McLean, Mary A.
name: Gill, Andrew B.
name: Brodie, Cara
name: Crawford, Robin
name: Latimer, John
name: Baldwin, Peter
name: Earl, Helena M.
name: Parkinson, Christine
name: Smith, Sarah
name: Hodgkin, Charlotte
name: Patterson, Ilse
name: Addley, Helen
name: Freeman, Susan
name: Moyle, Penny
name: Jimenez-Linan, Mercedes
name: Graves, Martin J.
name: Sala, Evis
name: Brenton, James D.
name: Gallagher, Ferdia A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/67/2321
/631/67/1059/99
/59/57
article

description: Abstract: This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant chemotherapy (NACT). Seventeen patients with HGSOC were imaged at 3 T and had biopsy samples taken prior to any treatment. The patients were divided into two groups: responders and non-responders based on Response Evaluation Criteria In Solid Tumours (RECIST) criteria. The following imaging metrics were calculated: apparent diffusion coefficient (ADC), apparent diffusion (Dapp) and apparent kurtosis (Kapp). Tumour cellularity and proliferation were quantified using histology and Ki-67 immunohistochemistry. Mean Kapp before therapy was higher in responders compared to non-responders: 0.69 ± 0.13 versus 0.51 ± 0.11 respectively, P = 0.02. Tumour cellularity correlated positively with Kapp (rho = 0.50, P = 0.04) and negatively with both ADC (rho = −0.72, P = 0.001) and Dapp (rho = −0.80, P < 0.001). Ki-67 expression correlated with Kapp (rho = 0.53, P = 0.03) but not with ADC or Dapp. In conclusion, Kapp was found to be a potential predictive biomarker of NACT response in HGSOC, which suggests that DKI is a promising clinical tool for use oncology and radiology that should be evaluated further in future larger studies.