cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Regulation of Satellite Cell Function and Myogenesis by Isoforms of C/EBPβ
Creators: name: Lee, Hwabin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: C/EBPβ
Isoforms
Transcription factor
Satellite cell
Duchenne muscular dystrophy
Primary myoblast
Myogenesis
LIP
LAP

description: Adult skeletal muscles have remarkable regenerative capacity. Muscle regeneration occurs when muscle tissue experiences injury, causing a population of normally quiescent muscle-resident stem cells, called satellite cells, to become activated. The CCAAT/enhancer binding proteins known as C/EBPs are transcription factors belonging to the bZIP family. Previous work from our lab has identified C/EBPβ as an important negative regulator of myogenesis. C/EBPβ expression is localized to muscle satellite cells and is downregulated upon induction to differentiate, mirroring the loss of Pax7 expression in early myogenesis. C/EBPβ expression also negatively regulates MyoD protein expression. Leaky ribosomal scanning of the Cebpb mRNA produces three C/EBPβ isoforms: LAP*, LAP and LIP, though the individual role of each of these isoforms has not been investigated in myoblasts. This thesis focuses on determining the role of each of the C/EBPβ isoforms during skeletal muscle differentiation. Forced expression of the C/EBPβ-LIP isoform in myoblasts led to a decrease in Myf5, MyoD, and myogenin expression under differentiation conditions when compared to empty vector controls. Further, the fusion of cells was greatly reduced following differentiation. C/EBPβ-LIP expressing cells also demonstrated a growth defect, with pronounced G1 arrest and features of senescence. In contrast, myoblasts expressing the C/EBPβ-LAP isoform has impaired differentiation, though this was not as pronounced as in C/EBPβ-LIP expressing cells and proliferated normally. While LIP is not normally expressed in primary myoblasts from healthy muscle, the ratio of LIP:LAP was increased in primary myoblasts isolated from mdx mice, an animal model for Duchenne muscular dystrophy. These findings suggest that the regulation of C/EBPβ isoform expression could regulate stem cell stamina and may contribute to defects in muscle regeneration in disease.
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 12/23
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2023, no. 12
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 03/23
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2023, no. 03
Trichoferus campestris
Creators: name: COCQUEMPOT, Christian
name: HENIN, Jean-Marc
name: JOUREZ, Benoit
name: RAPUZZI, Pierpaolo
name: ROQUES, Alain
name: DRUMONT, Alain
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Trichoferus
Trichoferus campestris

description: Trichoferus campestris (Faldermann, 1835)   Figs 1, 2 a-c, 4
 Callidium campestris Faldermann, 1835: Coleopterorum ab illustrissimo Bungio in China boreali, Mongolia et montibus Alaicis collectorum, nec non ab ill. Turczaninoffio et Stschukino e provincia Irkutzk missorum illustrationes. Mémoires présentés à l'Académie Impériale des Sciences de Saint-Pétersbourg (Sixième Série), Sciences Mathématiques, Physiques et Naturelles 2, p. 435.
Holotype femelle dans la collection de l’Institut Zoologique de l’Académie des Sciences de Russie à Saint-Petersbourg (Russie).
Localité typique: Chine (Chine boréale).
SYNONYMES.
 Stromatium turkestanicum Heyden, 1886: Deutsche Entomologische Zeitschrift, 30 (1):
p. 182, 193.
 Holotype femelle in collection du Senckenberg Deutsches Entomologisches Institut, Müncheberg (Allemagne).
 Localité typique: Kazakhstan (Turkestan), Wilhelm Koltze leg,
 Hesperophanes flavopubescens Kolbe, 1886: Archiv für Naturgeschichte, 52 (1): p. 219-220. Syntypes in Museum für Naturkunde - Leibniz Institute for Evolution and Biodiversity Science, Berlin (Allemagne).
 Localité typique: Corée du Sud, Séoul, août 1884, C. Gottsche leg.
 Hesperophanes rusticus Ganglbauer, 1887: Horae Societatis Entomologicae Rossicae, 20 (3- 4): p. 131, 133.
 Holotype in Naturhistorisches Museum Wien (Autriche); ex collection G. Sievers> L. Ganglbauer.
 Localité typique: Corée du Nord: Centre de la presqu’île coréenne, Pung-tung (Province de Kangwon), Otto Herz leg.
De nombreuses combinaisons taxonomiques ont été employées. Nous suggérons au lecteur intéressé de consulter la base de données Titan: http://titan.gbif.fr/sel_genann1.php?numero=9788
description: Published as part of COCQUEMPOT, Christian, HENIN, Jean-Marc, JOUREZ, Benoit, RAPUZZI, Pierpaolo, ROQUES, Alain & DRUMONT, Alain, 2022, État de l'invasion de Trichoferus campestris (Faldermann, 1835) au plan international et réflexion sur sa première interception en Belgique, pp. 1-24 in Belgian Journal of Entomology 129 on pages 4-6, DOI: 10.5281/zenodo.11584317
title: The Effect of Contacts on the Performance of Electron-Beam Controlled GaAs and Diamond Switches
Creators: name: Kennedy, Michael Kevin
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1992

description: The performance of GaAs and diamond as electron-beam controlled closing and opening switches has been studied. An emphasis has been placed on the effect of contacts on the current-voltage characteristics. The two materials studied were GaAs and diamond. Using the same semi-insulating GaAs wafer as a source of material, a bulk device and a p-i-n device have been fabricated and compared. The asymmetry of the pin diode allows operation at higher voltage because of the ability to suppress the lock-on effect. Whereas GaAs was ionized through cathodoluminescence; diamond, in the form of thin films, has been directly ionized by the electron-beam. The metal/diamond/n-silicon device studied has polarity dependent characteristics similar to the GaAs pin diode. It was shown that the lock-on effect is not dependent on whether the semiconductor is direct or indirect, but on the carrier injection mechanisms at the contacts.
Dances With 'Religion': A Critical History of the Strategic Uses of the Category of Religion by the Government of Canada and First Nations, 1885 to 1951
Creators: name: Ruecker, Michael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Canada
First Nations
Theory of Religion

description: This thesis examines the historical record of the late 19th and early 20th century Canadian law against indigenous ceremonies, such as the potlatch and the sun dance, in order to investigate whether an alternative narrative of this history is possible. The main source of data is the archive of the Department of Indian Affairs, containing all the official correspondence that the department sent and received regarding these ceremonies during the time that the law was in effect. Classifying these practices as religious ceremonies, I will argue, was not an obvious or necessary classification, but a strategic move that was beneficial in the short term, both for First Nations advocates of the ceremonies and for their federal government opponents. This research sheds light on the political relationships between Canada and its First Nations, as well as clarifying the ways in which 'religion' is a strategic, rather than an absolute, category.
Emerging economies - potentials, pledges and fair shares of greenhouse gas reduction
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: emerging economy
subject: greenhouse gas
subject: greenhouse gas reduction
subject: China
subject: Mexico
subject: Brasilien
subject: Indien
subject: South Africa
subject: Klima | Energie
subject: Climate | Energy

description: In this report we assess how ambitious emission reduction pledges of emerging economies are compared to business as usual emissions, the countries' mitigation potential and respective efforts based on different equity principles.
L'évaluation de la fiabilité de sites web sur la santé par les usagers réguliers de « l’internet santé » : le cas des étudiants universitaires
Creators: name: Levert-Gagnon, Valérie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: internet-santé
entrevues semi-dirigées

description: L’internet-santé a pris une importance croissante sur le Web au cours des dernières années. En effet, on recensait déjà en 2008 plus de 100 000 sites internet consacrés à la santé dans le monde (Donnely & al., 2008). Force est toutefois de constater qu’une proportion non négligeable de ces sites ne sont pas toujours dignes de confiance, ce qui invite à la vigilance des internautes. Dans le cadre de notre thèse de maîtrise en communication, nous nous sommes penchés sur l’évaluation subjective de la fiabilité de sites internet-santé par les usagers quotidiens de « l’internet-santé ». La question centrale à laquelle nous avons tenté de répondre est la suivante : « Comment les usagers de sites internet consacrés à la santé discriminent-ils, dans leur quotidien, les sites qu’ils considèrent comme étant fiables de ceux qui ne le sont pas ? ». Pour répondre à cette question, nous nous sommes intéressés au cas des étudiants universitaires milléniaux. La recherche a été effectuée sous forme d’entrevues individuelles semi-dirigées avec 19 étudiants de l’Université d’Ottawa. Tous les participants souffraient préalablement d’une condition médicale diagnostiquée, ce qui nous a permis d’entreprendre une discussion riche avec eux. À la lumière des témoignages, nous constatons que les jeunes usagers de l’internet-santé utilisent des stratégies de vérification de l’information, comme la comparaison des sources en ligne et l’appel à l’expertise d’un médecin, ainsi que des indicateurs de fiabilité qu’ils observent de façon subjective. Somme toute, nous pensons avoir contribué à l’étude des usages de l’internet-santé par les jeunes adultes, alors que cet outil génère beaucoup d’attention de la part des médias et du public.
Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. XII. Reverberation Mapping Results for 15 PG Quasars from a Long-Duration High-Cadence Campaign
Creators: name: Hu, Chen
name: Li, Sha-Sha
name: Yang, Sen
name: Yang, Zi-Xu
name: Guo, Wei-Jian
name: Bao, Dong-Wei
name: Jiang, Bo-Wei
name: Du, Pu
name: Li, Yan-Rong
name: Xiao, Ming
name: Songsheng, Yu-Yang
name: Yu, Zhe
name: Bai, Jin-Ming
name: Ho, Luis C.
name: Brotherton, Michael S.
name: Aceituno, Jesús
name: Winkler, Hartmut
name: Wang, Jian-Min
Publisher: name: arXiv
Year: 2025
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first results from long-term high-cadence spectroscopic monitoring of 15 PG quasars with relatively strong Fe II emission as a part of a broader reverberation mapping campaign performed with the Calar Alto Observatory 2.2m telescope. The $V$-band, 5100 Å continuum, and H$β$ broad emission line light curves were measured for a set of quasars for between dozens to more than a hundred epochs from May 2017 to July 2020. Accurate time lags between the variations of the H$β$ broad line fluxes and the optical continuum strength are obtained for all 15 quasars, ranging from $17.0_{-3.2}^{+2.5}$ to $95.9_{-23.9}^{+7.1}$ days in the rest frame. The virial masses of the central supermassive black holes are derived for all 15 quasars, ranging between $0.50_{-0.19}^{+0.18}$ and $19.17_{-2.73}^{+2.98}$ in units of $10^7 M_\odot$. For 11 of the objects in our sample, this is the first reverberation analysis published. Of the rest, two objects have been the subject of previous reverberation studies, but we determine time lags for these that are only half as long as found in the earlier investigations, which had only been able to sample much more sparsely. The remaining two objects have previously been monitored with high sampling rates. Our results here are consistent with the earlier findings in the sense that the time lag and the line width vary inversely consistent with virialization.
description: 21 pages, 20 figures, published in ApJS, March 2021
The gendering of part-time work in Victoria Police
Creators: name: Van Den Ham, Annigje
Publisher: name: Swinburne
Year: 2024

description: In police services, both in Australia and internationally, attention has been focused on increasing the representation of women. The diversity approach favored by Human Resource Management and organisational theorists has contended that flexible working practices, specifically part-time employment, are a crucial mechanism to achieving this. However, as this study highlights, part-time work has become increasingly sex-segregated and associated with lower status and lower paid work, resulting in poor career prospects relative to full-time employment. The current study draws upon quantitative research collected in Victoria Police in 2004 exploring the experiences of, and attitudes toward part-time work (Victoria Police 2004). Utilising Acker’s (1990) theory of gendered organisation as a theoretical framework for investigation, a feminist comparative research methodology was applied to secondary data, using gender as an explanatory construct. This research suggests that part-time employment is a ‘double jeopardy’ for women, as gender inequalities inherent to policing are further exacerbated. Part-time women have lower organisational status, compared to men. Women chose part-time work to care for young children, whereas men do so for personal and career interests. Relatedly, police women and men work part-time differently; men work part-time for less time and enjoy more flexible shift arrangements, compared to women. Finally, full-time women and men deem part-time work to be of less value than full-time. The application of a feminist comparative research methodology to gender-neutral research which emphasised diversity, offers a unique insight into a deeply gendered organisation, with mutually reinforcing structures and processes that serve to persistently uphold and repeatedly reproduce women’s marginalised place in the organisation, albeit in a new form. The growth of part-time work in Victoria Police, taken up predominately by women, if not closely monitored and adjusted accordingly, may be reinforcing the low value of part-time work and thereby exacerbating the gender inequality that already exists.
Geochemistry of Forest Rings in Northern Ontario: Identification of Ring Edge Processes in Peat and Soil
Creators: name: Brauneder, Kerstin M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: forest ring
reduced chimney
H2S
CH4
oxidation-reduction potential (ORP)

description: Forest rings are large features common in Ontario’s boreal forests that comprise circular topographic depressions in carbonate mineral soil that are filled with peat. This thesis documents differences in peat and soil chemistry along transects across the “Bean” and “Thorn North” rings, which are centered on accumulations of CH4 and H2S, respectively. Within the mineral soil, ring edges are characterized by strong negative anomalies in pH, ORP and carbonate, as well as positive anomalies of Al, Fe and Mn in the results of aqua regia and hydroxylamine-hydrochloride digestions. Within the peat, positive carbonate and pH anomalies are recorded. This antithetic relationship suggests vertical migration of carbonate species from clay to peat. An inverse relationship exists between ORP, versus redox inferred from aqua regia. Strong ORP lows occur where oxidized products show highest concentrations. This is interpreted to reflect the proliferation of autotrophic organisms occupying the strong redox gradient at the ring edge.
Whose Safety Matters? Exaltation, Risky Refugees, and Canadian Safe Country Practices
Creators: name: Field, Emily
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Canada
Designated Country of Origin
Exaltation
Safe Country
Safe Third Country Agreement
United States

description: This thesis seeks to examine what cultural work is done on behalf of the state by the Safe Third Country Agreement and Bill C-31’s designated country of origin policy? I will be drawing on the work of Critical Race feminists and Critical Security Studies theorists to examine the concept of safety, systems of domination, and the parameters of national belonging. I will be performing a discourses analysis of the government’s and the Canadian Council for Refugee’s year one report of the Safe Third Country Agreement. I will also be performing a discourse analysis of the Citizenship and Immigration Canada website’s discussion of designated countries of origin. I will argue that state exaltation constructs the state, refugees, and safety in a way that reifies systems of domination.
Les facteurs liés à la perception du soutien dans un contexte de douleur chronique : une analyse interprétative phénoménologique auprès de femmes francophones
Creators: name: Laliberté, Geneviève
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Douleur chronique
Étude qualitative
Analyse interprétative phénoménologique
Soutien social
Relation de couple
Concept de soi
Attachement

description: L’objectif de cette étude a été d’examiner les facteurs liés à la perception du soutien offert de la part de son partenaire, telle que rapportée par des femmes francophones ayant une condition chronique impliquant la douleur comme symptôme primaire. Cinq participantes francophones, âgées de 32 à 66 ans, ont fait partie de l’étude en participant à une entrevue semi-structurée. Les résultats ont été obtenus en utilisant la méthode d’analyse interprétative phénoménologique (Interpretative Phenomenological Analysis, [Smith & Osborn, 2003]). Les analyses ont indiqué 8 sous-thèmes classifiés parmi 3 thèmes superordonnés : 1) la perception du soutien, 2) le concept de soi, et 3) la relation de couple. Ces thèmes, ainsi que les applications empiriques et les retombées cliniques, sont discutés.
Guidance for conducting feasibility and pilot studies for implementation trials
Creators: name: Pearson, Nicole
name: Naylor, Patti-Jean
name: Ashe, Maureen C.
name: Fernandez, Maria
name: Yoong, Sze L.
name: Wolfenden, Luke
Publisher: name: BioMed Central
Year: 2020

description: Background Implementation trials aim to test the effects of implementation strategies on the adoption, integration or uptake of an evidence-based intervention within organisations or settings. Feasibility and pilot studies can assist with building and testing effective implementation strategies by helping to address uncertainties around design and methods, assessing potential implementation strategy effects and identifying potential causal mechanisms. This paper aims to provide broad guidance for the conduct of feasibility and pilot studies for implementation trials. Methods We convened a group with a mutual interest in the use of feasibility and pilot trials in implementation science including implementation and behavioural science experts and public health researchers. We conducted a literature review to identify existing recommendations for feasibility and pilot studies, as well as publications describing formative processes for implementation trials. In the absence of previous explicit guidance for the conduct of feasibility or pilot implementation trials specifically, we used the effectiveness-implementation hybrid trial design typology proposed by Curran and colleagues as a framework for conceptualising the application of feasibility and pilot testing of implementation interventions. We discuss and offer guidance regarding the aims, methods, design, measures, progression criteria and reporting for implementation feasibility and pilot studies. Conclusions This paper provides a resource for those undertaking preliminary work to enrich and inform larger scale implementation trials.
Constraining the Source Distribution of Meltwater Pulse 1A Using Near- and Far-Field Sea-level Data
Creators: name: Liu, Jean
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: sea-level
geophysics
glacial isostatic adjustment
sea-level modelling
climate change

description: Meltwater pulse 1A (MWP-1A) is the largest land ice melt event of the last deglaciation. In a period of no more than 340 years, between 14.65 and 14.31 ka (Dechamps et al, 2012), ~10% of the total deglacial sea-level rise occurred (Hanebuth et al, 2000; Peltier and Fairbanks, 2006; Deschamps et al, 2012), resulting in the highest reported rate of global mean sea-level rise in the geological record, which may have exceeded 4 m per century (Deschamps et al, 2012). Yet, the implications of MWP-1A for constraining the rates of the underlying processes and its role in the sequence of climate events during Termination 1 remain unclear due to the lack of information on its melt source distribution. While glacial isostatic adjustment (GIA) modelling experiments (Clark et al, 2002; Bassett et al, 2005; Deschamps et al, 2012) and recent assessments of ice-sheet histories (Carlson and Clark, 2012) suggest that at least 50% of the event may have come from Antarctica, other interpretations of Antarctic ice-extent and sea-level records suggest a substantially smaller (including zero) Antarctic contribution (Ackert et al, 2007; Mackintosh et al, 2011; Whitehouse et al, 2012). In this study, we show that after reassessments of local MWP-1A amplitudes at Barbados and Sunda Shelf based on the well-constrained timing derived from the Tahiti sea-level record (Deschamps et al, 2012), the sea-level data from Barbados, Sunda Shelf, and Tahiti do not provide as tight of a constraint on the Antarctic contribution as previously thought. We find that between 1 to 10 m sea-level equivalent (sle) could have melted from the Antarctic, compared to 7 to 15 m sle from previous analyses (Clark et al, 2002; Bassett et al, 2005; Deschamps et al, 2012). To better constrain the source of MWP-1A, we also consider sea-level data from Scotland (Shennan et al, 2000), which have, until now, been excluded from MWP-1A fingerprinting experiments because they are strongly influenced by local ice unloading. To overcome this, we isolate the elastic MWP-1A amplitude (i.e. fingerprint signal) at this location using a suite of models that provide optimal fits to the Scottish data, and thereby remove near-field contamination. Preliminary results show that the inclusion of these data leads to an improved MWP-1A source distribution constraint compared to that obtained using the far- and intermediate-field data alone.
On Inverse Problems for a Beam with Attachments
Creators: name: Mir Hosseini, Farhad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Vibration
Beam with attachments
Fundamental Frequency
Inverse problems
Eigenvalue

description: The problem of determining the eigenvalues of a vibrational system having multiple lumped attachments has been investigated extensively. However, most of the research conducted in this field focuses on determining the natural frequencies of the combined system assuming that the characteristics of the combined vibrational system are known (forward problem). A problem of great interest from the point of view of engineering design is the ability to impose certain frequencies on the vibrational system or to avoid certain frequencies by modifying the characteristics of the vibrational system (inverse problem). In this thesis, the effects of adding lumped masses to an Euler-Bernoulli beam on its frequencies and their corresponding mode shapes are investigated for simply-supported as well as fixed-free boundary conditions. This investigation paves the way for proposing a method to impose two frequencies on a system consisting of a beam and a lumped mass by determining the magnitude of the mass as well as its position along the beam.
Supplementary document for Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry - 5420487.pdf
Creators: name: Nakamichi, Yu
name: Chiu, Kai-Shih
name: Sun, Chia-Wei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document and figures
Whole Exome Sequencing to Identify Disease-Causing Mutations in Lower Motor Neuron Disease and Peripheral Neuropathy
Creators: name: Wagner, Justin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Charcot-Marie-Tooth
Next Generation Sequencing
Whole-Exome Sequencing
Peripheral Neuropathy
Lower Motor Neuron Disease

description: Lower motor neuron diseases and peripheral neuropathies are two groups of diseases that include multiple rare disorders where many causes are unknown and definitive treatments are unavailable. Understanding the molecular etiology of these genetic diseases provides an opportunity for rapid diagnosis, preconception genetic counseling and, in a subset, direction for the development of future treatment options. The recent introduction of whole exome sequencing (WES) marks a new era in Mendelian genetic disease research as the majority of the coding region of the genome can be sequenced in a timely and cost-effective manner. In this study, WES was used to investigate the molecular etiology of a cohort of 37 patients presenting with lower motor neuron disease or peripheral neuropathy. A molecular diagnosis was determined for seven patients informing the diagnostic utility of WES. Novel phenotypes were found for three genes originally associated with a different disorder. Finally, the foundation has been laid, through the use of functional studies and large scale data-sharing, to identify novel disease-causing genes for lower motor neuron disease and peripheral neuropathy.
L’influence de l’accentuation dans l’apprentissage de nouveaux mots chez les jeunes enfants unilingues et bilingues
Creators: name: Godbout-Beaulieu, Sophie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: apprentissage lexical
bilinguisme
accentuation
développement de la phonologie

description: Les présentes études ont comme but d’examiner les relations entre l’accentuation et la perception des contrastes consonantiques lors de l’apprentissage de nouveaux mots chez les nourrissons unilingues anglophones et bilingues de 17 et 20 mois. La tâche de choix visuel est utilisée à travers deux études afin d’explorer cette question de recherche. La première étude s’intéresse aux nourrissons unilingues, tandis que la seconde étude explore la performance des nourrissons bilingues. Nous prédisons que la sensibilité aux détails phonologiques s’améliore avec l’âge, que le contraste phonologique est mieux perçu lorsqu’il est accentué, que les nourrissons unilingues distinguent mieux les contrastes en syllabe initiale, que les nourrissons bilingues distinguent les contrastes consonantiques aussi bien en syllabe initiale qu’en syllabe finale et que les nourrissons unilingues et bilingues réussissent la tâche d’apprentissage lexical. Les résultats de la première étude suggèrent que les nourrissons anglophones de 20 mois distinguent particulièrement mieux le contraste consonantique lorsque le changement est accentué et situé en position syllabique initiale, comme démontré par un temps de fixation de l’objet cible plus élevé lorsque le mot est prononcé correctement que lorsqu’il est prononcé incorrectement. L’accentuation semble aider les nourrissons de 17 et 20 mois à mettre en relief le changement consonantique en position syllabique initiale dans les premières 2 000 ms des essais. Les résultats de la deuxième étude indiquent que les nourrissons bilingues de17 et 20 mois distinguent les prononciations incorrectes des prononciations correctes. La position de l’accentuation semble influencer la perception du changement phonétique chez les nourrissons bilingues, avec une meilleure discrimination des détails phonétiques dans les mots iambiques. Toutefois, l’accentuation du contraste phonétique ne semble pas influencer leurs réponses. En somme, des différences développementales et linguistiques sont notées et discutées à travers nos études avec un avantage développemental chez les nourrissons bilingues.
Gender-Responsive Public Transportation in the Dammam Metropolitan Region, Saudi Arabia
Creators: name: Al-Rashid, Muhammad Ahmad
name: Nahiduzzaman, Kh  Md
name: Ahmed, Sohel
name: Campisi, Tiziana
name: Akgün, Nurten
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: The limited availability of public transportation in Saudi Arabia leads to an increased demand for private vehicles. An increase in using private cars does not meet the global sustainability goals, e.g., reducing energy consumption and improving the air quality. Road users should be encouraged to use sustainable mobility modes, particularly public transportation, equally accessible to both men and women However, women’s mobility has been somewhat limited and challenged in spatio-temporal terms, and partly due to socio-cultural barriers. This study attempts to understand the gender experience of a sample of public transport users and consider their aspirations and needs into daily mobility. A survey campaign (structured interviews and online questionnaires) was launched in the Dammam Metropolitan Region (DMR), taking four different types of respondents into account. The results suggest a predominant preference for taxis for shopping and leisure activities due to a poor public transport service, pivotally characterized by limited operational routes, hours, and infrastructure. This study ponders upon the adequacy of the supporting infrastructures and interior design of the public buses to women’s needs and compare them with global best practices. The results suggest that, due to the absence of a gender-responsive design and infrastructure, women are forced to use taxis, although privacy and a sense of insecurity often become concerns when traveling alone or with children. The study results allow future research to be expanded, considering women’s mobility patterns, needs, and embedded barriers by comparing the results with current transport policies, plans, and practices.
Le seidr des anciens Scandinaves et le noaidevuohta des Sâmes : aspects chamaniques et influences mutuelles
Creators: name: Leduc, Céline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: seidr
noaidevuohta
anciens Scandinaves
Sâmes
Vikings
Lapons
rituels
acculturation

description: La thèse analyse le rituel du seidr (pratique utilisée entre autres pour la divination, la guérison et la guerre sur des plans surnaturels) des anciens Scandinaves et celui du noaidevuohta (rituel chamanique pratiqué par les Sâmes) chez les Sâmes. Le seidr était pratiqué surtout par des femmes qui se déplaçaient d’une ferme à l’autre. Il était directement lié au dieu Ódinn, tel que décrit dans l’Ynglinga saga. Quant au noaidevuohta, apparemment l’apanage des hommes, il participait au complexe circumpolaire des chasseurs/éleveurs du renne ou du caribou. Les deux complexes rituels ont été intégrés dans leur culture respective, tout en possèdant des différences. Il est impossible, dans l’état actuel de la recherche, de déterminer s’il y a eu des emprunts de part et d’autre. Selon les conclusions de nos recherches, les deux rituels sont de nature chamanique, s’inscrivant au nouveau paradigme circumpolaire des études contemporaines. En revanche, il n’existe pas de consensus au sujet de la nature chamanique ou non, ni au sujet de l’origine, des rituels en question. Il y a très peu de recherches en langue française sur le sujet, la majorité des études ont été réalisées en langue anglaise ou dans des langues scandinaves. Les textes originaux ne sont d’ailleurs pas tous traduits en français. Notre thèse contribuera de manière significative à la recherche. Nous avons établi un lexique des catégories « prêtre », « sorcier » et « chamane » de la Scandinavie préchrétienne. De plus, nous avons remis dans leur contexte culturel les textes et les objets de la culture matérielle, en utilisant des méthodes de l’anthropologie culturelle et de l’histoire, tout en intégrant les recherches archéologiques pertinentes et l’étude des textes. L’objectif de cette thèse est de démontrer 1) que le seidr et le noaidevuohta sont apparentés et de nature chamanique, et 2) qu’il est impossible de déterminer la direction (des anciens Scandinaves vers les Sâmes ou le contraire) des échanges et des influences pour chacun des deux rituels.
title: Newsletter Allgemeinmedizin Ausgabe 01/2020
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2020
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2020, no. 1
Restoring Calibration for Aligned Large Language Models: A Calibration-Aware Fine-Tuning Approach
Creators: name: Xiao, Jiancong
name: Hou, Bojian
name: Wang, Zhanliang
name: Jin, Ruochen
name: Long, Qi
name: Su, Weijie J.
name: Shen, Li
Publisher: name: arXiv
Year: 2025
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: One of the key technologies for the success of Large Language Models (LLMs) is preference alignment. However, a notable side effect of preference alignment is poor calibration: while the pre-trained models are typically well-calibrated, LLMs tend to become poorly calibrated after alignment with human preferences. In this paper, we investigate why preference alignment affects calibration and how to address this issue. For the first question, we observe that the preference collapse issue in alignment undesirably generalizes to the calibration scenario, causing LLMs to exhibit overconfidence and poor calibration. To address this, we demonstrate the importance of fine-tuning with domain-specific knowledge to alleviate the overconfidence issue. To further analyze whether this affects the model's performance, we categorize models into two regimes: calibratable and non-calibratable, defined by bounds of Expected Calibration Error (ECE). In the calibratable regime, we propose a calibration-aware fine-tuning approach to achieve proper calibration without compromising LLMs' performance. However, as models are further fine-tuned for better performance, they enter the non-calibratable regime. For this case, we develop an EM-algorithm-based ECE regularization for the fine-tuning loss to maintain low calibration error. Extensive experiments validate the effectiveness of the proposed methods.
Using HIT to Support Informal Caregivers of Cancer Patients at Home: a Needs Assessment
Creators: name: Al Awar, Zeina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Informal Caregiving
Family Caregiving
Caregiving
Home Care
Health Information Technology
Informational Needs
User Personas
User-Centered Design
Palliative Care
Needs Assessment
Cancer Care

description: Introduction: This research investigated the requirements of an HIT solution that is usable and useful to informal caregivers of cancer patients on home palliative care. Methodology: A needs assessment method was used with an exploratory and a confirmatory stage. Eight semi-structured interviews and two focus groups were used for data collection. Qualitative content analysis was used to analyse caregiver experiences with both inductive and deductive coding. Results/Discussion: Expressed and unexpressed caregiver needs were extracted into four categories, Implementation, Presentation, Information, and Practical Caregiving, and used to create the application requirements. Five user personas were created based on caregiving intensity and the functional level of the patients, a method of tailoring the application content to the different personas was created, and a low-fidelity prototype of the application was designed. Conclusion: The findings of this research can improve the preparedness and coping of informal caregivers of cancer patients on home palliative care.
Amyloid Beta Peptide Induces D-serine Dependent NMDAR Dysfunction in the Mouse Hippocampus
Creators: name: Wang, Boyang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: D-serine
Amyloid beta
Alzheimer's Disease
NMDA receptor

description: The amyloid beta peptide (Aβ) plays an important role in Alzheimer’s disease (AD). Increasing evidence suggest that overactivation of extrasynaptic N-methyl-D-aspartate receptors (NMDARs) mediate Aβ-induced excitotoxicity. In serine racemase knockout (SRKO) mice with significantly depleted D-serine levels, Aβ-induced excitotoxicity is attenuated. Using SRKO mice, this thesis attempts to determine the effects of Aβ on synaptic and extrasynaptic NMDAR function, and how D-serine can alter these Aβ- mediated effects. In CA1 pyramidal neurons, Aβ significantly depresses evoked synaptic NMDAR excitatory postsynaptic currents (EPSCs), and this effect is even greater in SRKO mice. The same effect was also observed on isolated evoked extrasynaptic NMDAR currents. During synaptic NMDAR current recordings, Aβ potentiated the holding current in wild type (WT) mice, but not SRKO mice, suggesting an increase in extrasynaptic NMDAR activation in WT, but not in SRKO mice. SRKO mice attenuated Aβ-induced holding current shift and had reduced basal tonic NMDAR activation. These data, along with evidence from previous studies in the literature, suggest that low levels of D-serine can alter NMDAR function in the presence of Aβ. These findings provide insight for future experiments in exploring the importance of D-serine in AD.
title: Newsletter Allgemeinmedizin Ausgabe 02/2020
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2020
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2020, no. 2
Automatic Recognition of Speech-Evoked Brainstem Responses to English Vowels
Creators: name: Samimi, Hamed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Neural networks
Automatic speech recognition
Speech-evoked auditory brainstem response
Principal component analysis

description: The objective of this study is to investigate automatic recognition of speech-evoked auditory brainstem responses (speech-evoked ABR) to the five English vowels (/a/, /ae/, /ao (ɔ)/, /i/ and /u/). We used different automatic speech recognition methods to discriminate between the responses to the vowels. The best recognition result was obtained by applying principal component analysis (PCA) on the amplitudes of the first ten harmonic components of the envelope following response (based on spectral components at fundamental frequency and its harmonics) and of the frequency following response (based on spectral components in first formant region) and combining these two feature sets. With this combined feature set used as input to an artificial neural network, a recognition accuracy of 83.8% was achieved. This study could be extended to more complex stimuli to improve assessment of the auditory system for speech communication in hearing impaired individuals, and potentially help in the objective fitting of hearing aids.
title: Newsletter Allgemeinmedizin Ausgabe Dezember 2020
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2020
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2020, no. 4
title: Newsletter Institut für Allgemeinmedizin Ausgabe März 2021
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2021
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2021, no. 1
Positive Youth Development's 6th C: The Nature of Contribution in University Athletes
Creators: name: Deal, Colin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: 5Cs model
emerging adulthood
self-determination theory
university athletes
PYD

description: The overall purpose of this Master’s thesis was to gain an in-depth understanding of university student-athletes’ contributions. The first manuscript included in this thesis assesses the suitability of the Positive Youth Development Very Short Form (PYD-VSF) for use with an emerging adult athlete population, using data from 74 university student-athletes who completed an online questionnaire. The findings suggest that the PYD-VSF is not an appropriate measure for this population. The second and third manuscript used data from 10 interviews. The second manuscript examined university student-athletes’ motivations to contribute and found participants reported that contributing served as a way to satisfy the basic psychological needs and possessed multiple motives simultaneously. The third manuscript explored the facilitators and barriers relating to university student-athletes’ contributions and found that academic and athletic time constraints were significant barriers to contribution and teammates, coaches, and staff members of the athletics department facilitated contributions.
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Juli 2021
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2021
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2021, no. 2
A Clinical and Economic Perspective of Ophthalmological Disease in Rural India
Creators: name: Turpin, MacKenzie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Blindness
Cataract
India
Economics
Epidemiology
Ophthalmology

description: Background: Cataracts represent the major cause of blindness worldwide, disproportionately affecting such low-income countries as India. Accordingly, these cases are largely preventable, resulting in avoidable clinical and economic effects. Methods: This analysis consists of three parts: i) an exploratory systematic review of the literature to determine the extent to which the economic impact of blindness in India is known; ii) an epidemiological investigation of ophthalmological diagnosis in school age children in rural India; and iii) an examination of the determinants of cataract incidence and cataract surgical outcomes in a special Indian population through binomial logistic regression. Results: Cost estimates for blindness in India were $4.4 billion in 1997 – further investigation with current figures is needed. Costs also stem from more qualitative effects such as caregivers missing work as a result of depression. Vitamin A deficiency was not evident in school age children, though select ophthalmic diagnoses were associated with age and gender. In the adult population, determinants of cataract incidence included age, gender, occupation and caste, while surgical outcome was mainly dependent on occupation and severity of ophthalmic disease. Conclusions: The issue of blindness in India is multifaceted, and complicated by lack of knowledge of current prevalence. Further investigation into how select factors contribute to ophthalmic health, and into possible preventative strategies, is needed.
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Oktober 2021
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2021
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2021, no. 3
Organizational Resilience Indicators Based on a Salutogenic Orientation
Creators: name: Tracey, Shannon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Organizational Resilience
Business Continuity Planning
Salutogenesis
Indicators

description: Disasters such as the recent parliament shooting in Ottawa, Superstorm Sandy, and the Great Japan Sea Earthquake and tsunami are reminders of the roles essential service organizations have in maintaining public health. On a daily basis, organizations are expected to operate under normal conditions, providing goods, services, and community supports. In crisis situations, it is critical that these organizations continue to operate and contribute to adaptive response and recovery in a community. Business continuity planning focuses on ensuring continued functioning of core operations during a disruption. Inherent to the business continuity field is a prevent-and-protect approach to preparedness activities. Asset-mapping exercises have the potential to balance the predominantly risk-based field by focusing on the strengths and capabilities already present within an organization. To understand the value of asset-mapping activities in business continuity plans (BCPs), indicators for organizational resilience are needed. Indicators have the potential to provide essential service organizations with a way to gauge the value of their BCP activities. In addition, this information can help guide decision-makers when developing BCPs. This research is part of a larger project at the University of Ottawa focused on building the empirical evidence base for BCPs and organizational resilience. This thesis, as a sub-study within the larger project, explores assets and indicators for organizational resilience to contribute to the effective evaluation and engagement of organizations in business continuity planning efforts. Emergent themes highlight the importance of assets and their contribution to the adaptive capacity of an organization in the event of a disaster. This study also provides an example list of 28 SMARTT organizational resilience indicators directly derived from organizational assets, providing information that researchers and essential service organizations can use to evaluate business continuity planning activities in relation to organizational resilience.
Development and Validation of UV Spectroscopic Method for Estimation of Empagliflozin in Tablet Dosage Form
Creators: name: Bachhav UL*
name: Chaudhari SP
name: Manure SS
name: Joshi KS
name: Patil NM
name: Patil RR
Publisher: name: Zenodo
Year: 2024

description: Abstract

To develop and validate simple, rapid, linear, accurate, precise and economical UV Spectroscopic method for estimation of Empagliflozin in tablet dosage form.

The drug is freely soluble in analytical grade methanol. The drug was identified in terms of solubility studies and on the basis of melting point done on melting point apparatus of Equiptronics. It showed absorption maxima were determined in analytical grade methanol. The drug obeyed the Beer’s law and showed good correlation of concentration with absorption which reflect in linearity. The UV spectroscopic method was developed for estimation of Empagliflozin in tablet dosage form and also validated as per ICH guidelines.

The drug is soluble in analytical grade methanol, slightly soluble in ethanol and very slightly soluble in water. So, the analytical grade methanol is used as a diluent in method. The melting point of Empagliflozin was found to be 151-152˚C (uncorrected). It showed absorption maxima 276 nm in analytical grade methanol. On the basis of absorption spectrum the working concentration was set on 50µg/ml (PPM). The linearity was observed between 10-90 μg/ml (PPM). The results of analysis were validated by recovery studies. The recovery was found to be 98.75, 99.00 and 99.17% for three levels respectively. The % RSD for precision was found to be 0.90% and for Ruggedness is 0.56%.

A simple, rapid, linear, accurate, precise and economical UV Spectroscopic method has been developed for estimation of Empagliflozin in tablet dosage form. The method could be considered for the determination of Empagliflozin in quality control laboratories.

Keywords: Empagliflozin, UV Spectrophotometer, Melting Point, Assay Method, Validation, Accuracy, Linearity, Ruggedness, Precision.