cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Theory of Conductivity of Chiral Particles
Creators: name: Kailasvuori, Janik
name: Sopik, Bretislav
name: Trushin, Maxim
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this methodology focused paper we scrutinize the application of the band-coherent Boltzmann equation approach to calculating the conductivity of chiral particles. As the ideal testing ground we use the two-band kinetic Hamiltonian with an N-fold chiral twist that arise in a low-energy description of charge carriers in rhombohedrally stacked multilayer graphene. To understand the role of chirality in the conductivity of such particles we also consider the artificial model with the chiral winding number decoupled from the power of the dispersion. We first utilize the approximate but analytically solvable band-coherent Boltzmann approach including the ill-understood principal value terms that are a byproduct of several quantum-many body theory derivations of Boltzmann collision integrals. Further on, we employ the finite-size Kubo formula with the exact diagonalization of the total Hamiltonian perturbed by disorder. Finally, we compare several choices of Ansatz in the derivation of the Boltzmann equation according to the qualitative agreement between the Boltzmann and Kubo conductivities. We find that the best agreement can be reached in the approach where the principle value terms in the collision integral are absent.
description: 21 pages, 5 figures
Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health
Creators: name: Williams, Ronald
name: Özkaynak, Haluk
name: Neas, Lucas
name: Edwards, Stephen
name: Gallagher, Jane
name: Andrews, Gina
name: Heidenfelder, Brooke
name: Williams, Ann
name: Johnson, Markey
name: Reif, David
name: Inmon, Jefferson
name: Hubal, Elaine
name: Hudgens, Edward
name: Rhoney, Scott
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions. Methods/Design 205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specific Immunoglobulin E, polycyclic aromatic hydrocarbons, volatile organic carbon metabolites) and clinical indicators of health outcome (immunological, cardiovascular and respiratory). In addition, blood gene expression and candidate SNP analyses were conducted. Discussion Based on an integrative design, the MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes. Project approval IRB Number 05-EPA-2637: The human subjects' research protocol was reviewed by the Institutional Review Board (IRB) of the University of North Carolina; the IRB of Westat, Inc., the IRB of the Henry Ford Health System; and EPA's Human Subjects' Research Review Official.
Der Einfluss kurzzeitiger intermittierender Hypoxie auf die Leistungsfähigkeit
Creators: name: Schomburg, Nadine
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität Hannover
Year: 2008
Subjects: subject: Neocytolyse
subject: Ventilation
subject: Ausdauerleistung
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: [no abstract]
"Wie viel Gefängnis braucht die Gesellschaft heute?" : Expertenbefragung : Statements zum Schwerpunktthema
Creators: name: Kinzig, Jörg
name: Denigot, Anaïs
name: Arloth, Frank
name: Coester, Marc
Publisher: name: Universität Tübingen
Year: 2018

description: Nur Beitrag von Prof. Jörg Kinzig
Interplay of the electronic and lattice degrees of freedom in A_{1-x}Fe_{2-y}Se_{2} superconductors under pressure
Creators: name: Bendele, M.
name: Marini, C.
name: Joseph, B.
name: Pierantozzi, G. M.
name: Caporale, A. S.
name: Pomjakushina, E.
name: Conder, K.
name: Krzton-Maziopa, A.
name: Irifune, T.
name: Shinmei, T.
name: Pascarelli, S.
name: Bianconi, A.
name: Dore, P.
name: Saini, N. L.
name: Postorino, P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The local structure and electronic properties of Rb$_{1-x}$Fe$_{2-y}$Se$_2$ are investigated by means of site selective polarized x-ray absorption spectroscopy at the iron and selenium K-edges as a function of pressure. A combination of dispersive geometry and novel nanodiamond anvil pressure-cell has permitted to reveal a step-like decrease in the Fe-Se bond distance at $p\simeq11$ GPa. The position of the Fe K-edge pre-peak, which is directly related to the position of the chemical potential, remains nearly constant until $\sim6$ GPa, followed by an increase until $p\simeq 11$ GPa. Here, as in the local structure, a step-like decrease of the chemical potential is seen. Thus, the present results provide compelling evidence that the origin of the reemerging superconductivity in $A_{1-x}$Fe$_{2-y}$Se$_2$ in vicinity of a quantum critical transition is caused mainly by the changes in the electronic structure.
Applying GRADE-CERQual to qualitative evidence synthesis findings–paper 6: how to assess relevance of the data
Creators: name: Pantoja, Tomas
name: Booth, Andrew
name: Chandler, Jacqueline
name: Flottorp, Signe
name: Tucker, Joseph
name: Wainwright, Megan
name: Tunςalp, Özge
name: Glenton, Claire
name: Carlsen, Benedicte
name: Noyes, Jane
name: Garside, Ruth
name: Bohren, Meghan A
name: Munthe-Kaas, Heather
name: Lewin, Simon
name: Colvin, Christopher J
name: Rashidian, Arash
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The approach has been developed to support the use of findings from qualitative evidence syntheses in decision-making, including guideline development and policy formulation. CERQual includes four components for assessing how much confidence to place in findings from reviews of qualitative research (also referred to as qualitative evidence syntheses): (1) methodological limitations, (2) coherence, (3) adequacy of data and (4) relevance. This paper is part of a series providing guidance on how to apply CERQual and focuses on CERQual’s relevance component. Methods We developed the relevance component by searching the literature for definitions, gathering feedback from relevant research communities and developing consensus through project group meetings. We tested the CERQual relevance component within several qualitative evidence syntheses before agreeing on the current definition and principles for application. Results When applying CERQual, we define relevance as the extent to which the body of data from the primary studies supporting a review finding is applicable to the context (perspective or population, phenomenon of interest, setting) specified in the review question. In this paper, we describe the relevance component and its rationale and offer guidance on how to assess relevance in the context of a review finding. This guidance outlines the information required to assess relevance, the steps that need to be taken to assess relevance and examples of relevance assessments. Conclusions This paper provides guidance for review authors and others on undertaking an assessment of relevance in the context of the CERQual approach. Assessing the relevance component requires consideration of potentially important contextual factors at an early stage in the review process. We expect the CERQual approach, and its individual components, to develop further as our experiences with the practical implementation of the approach increase.
Paratesba rougemonti Bordoni, 2011, nov.sp.
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Paratesba
Paratesba rougemonti

description: Paratesba rougemonti nov.sp. (Figs 2, 13-14, 31-33) H o l o t y p e: Sabah, Danum Vallery BRL, G. de Rougemont 14-16.II.2007, Fit (cR); paratypes: same data, 1 (cB); Malaysia, Sabah, Lahad Datu, Ulu Segama For. Res., Danum Valley Forest Centre, 04° 57.9'N- 117° 48.1'E, 200 mt, XI.2005, 1° Forest, FIT, coll. Mann, Slade & Villanueva, OUMNH-2006-051, 1 (OUMNH). D e s c r i p t i o n: Body length 15 mm; length from anterior margin of head to posterior margin of elytra 6,5 mm. Body narrow. Similar to the previous species but larger, with labrum reddish brown of a different shape; abdominal segments more reddened, with 5° and 6° segments to the posterior margin and the genital segment reddish. Head with barely visible carinae (Fig. 13), and very superficial punctuation, arranged in more or less regular series. On the clypeus are striolae and the punctuation on the sides is larger and deeper. Labrum as in Fig 2. Pronotum similar to that to Paratesba minuta but with more abundant punctuation; anterior margin as in Fig. 14. Abdomen with fine and dense polygonal microreticulation and with fine and sparse punctuation, concentrated on the sides. Tergite and sternite of the male genital segment as in Figs 32-33. Aedeagus (Fig. 31). D i s t r i b u t i o n: It is known only from the type locality. E t y m o l o g y: Dedicated to Guillaume de Rougemont.
description: Published as part of Bordoni, A., 2011, New data on the Oriental Xantholinini. XXIV. Nine new taxa of Paratesba from Danum Valley, Sabah, and dichotomic key of the bornean species (Coleoptera, Staphylinidae). 221 ° contribution to the knowledge of the Staphylinidae, pp. 483-499 in Linzer biologische Beiträge 43 (1) on page 485
Paratesba silvestris Bordoni, 2011, nov.sp.
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Paratesba
Paratesba silvestris

description: Paratesba silvestris nov.sp. (Figs 4, 17-18) H o l o t y p e: Malaysia, Sabah, Lahad Datu, Ulu Segama For. Res., Danum Valley Forest Centre, 04° 57.9'N- 117° 48.1'E, 200 mt, XI.2005, 1° Forest, FIT, coll. Mann, Slade & Villanueva, OUMNH-2006-051 (OUMNH); Paratype: same data, 04°58.660'N, 117°53.410'E, 2° Forest, FIT, Slade & Villanueva III.2005, 1, (cB). D e s c r i p t i o n: Body length 20 mm; length from anterior margin of head to posterior margin of elytra 9 mm. Narrow body. Colour similar to that of Paratesba minuta: I describe the species that is devoid of the genital segment and aedeagus because especially recognizable for the shape of the labrum, colour and punctuation. Head with carinae well clear and smooth, arranged as in Fig. 17; punctuation of medium size, deep, larger on the sides; there are some minute irregular striolae on the clypeus. Labrum as in Fig. 4. Puntuation on the head confluent. Pronotum much longer and the width of the head; anterior margin as in Fig. 18. Puntuation at the anterior angles very sharp, deep, thinner at the posterior angles; dorsal series of 6 spots in front and back 2-3 spots. Elytra with the usual shape and punctuation. Abdomen similar to Paratesba sabahensis D i s t r i b u t i o n: It is known only from the type locality. E t y m o l o g y: Fromthelatin silvestris - e (sylvan).
description: Published as part of Bordoni, A., 2011, New data on the Oriental Xantholinini. XXIV. Nine new taxa of Paratesba from Danum Valley, Sabah, and dichotomic key of the bornean species (Coleoptera, Staphylinidae). 221 ° contribution to the knowledge of the Staphylinidae, pp. 483-499 in Linzer biologische Beiträge 43 (1) on page 486
Paratesba lithocarpi Bordoni, 2011, nov.sp.
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Paratesba
Paratesba lithocarpi

description: Paratesba lithocarpi nov.sp. (figs 9, 27-28, 48-50) H o l o t y p e: Malaysia, Sabah, Lahad Datu, Ulu Segama For. Res., Danum Valley Forest Centre, 04° 57.9'N- 117° 48.1'E, 200 mt, XI.2005, 1° Forest, FIT, coll. Mann, Slade & Villanueva, OUMNH-2006-051 (OUMNH); paratypes: same data, 2 (OUMNH), 2 (cB), 1 (cR). D e s c r i p t i o n: Body length 22,5 mm; length from anterior margin of head to posterior margin of elytra 10,5 mm. Body very robust. Head, pronotum, scutellum, abdomen blacks; elytra red ligth orange, almost yellow; apex of genital segment red. Head with carinae arranged as in Fig.27, with punctuation similar to Paratesba fluvialis but more dense. Clypeus with minute striolae, more or less obvious. Antennae with 3° article muh longer than 2°. Labrum as in Fig. 9. Pronotum massive, broad, with anterior margin as in Fig. 28, with Paratesba fluvialis -like punctuation, but with dorsal series of 5-6 spots in front and 3 spots behind. Elytra with the usual form and punctuation. Abdomen with traces of transverse microstriature and Paratesba fluvialis -like punctuation, but much thicker. Tergite and sternite of the male genital segment as in Figs 49-50. Aedeagus (Fig. 48). D i s t r i b u t i o n: It is known only from the type locality. E t y m o l o g y: The specific epithet refers to the lithocarp forest in where live the species.
description: Published as part of Bordoni, A., 2011, New data on the Oriental Xantholinini. XXIV. Nine new taxa of Paratesba from Danum Valley, Sabah, and dichotomic key of the bornean species (Coleoptera, Staphylinidae). 221 ° contribution to the knowledge of the Staphylinidae, pp. 483-499 in Linzer biologische Beiträge 43 (1) on page 488
Irradiated Interfaces in the Ara OB1, Carina, Eagle Nebula, and Cyg OB2 Massive Star Formation Regions
Creators: name: Hartigan, P.
name: Palmer, J.
name: Cleeves, L. I.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Regions of massive star formation offer some of the best and most easily-observed examples of radiation hydrodynamics. Boundaries where fully-ionized H II regions transition to neutral/molecular photodissociation regions (PDRs) are of particular interest because marked temperature and density contrasts across the boundaries lead to evaporative flows and fluid dynamical instabilities that can evolve into spectacular pillar-like structures. When detached from their parent clouds, pillars become ionized globules that often harbor one or more young stars. H2 molecules at the interface between a PDR and an H II region absorb ultraviolet light from massive stars, and the resulting fluoresced infrared emission lines are an ideal way to trace this boundary independent of obscuring dust. This paper presents H2 images of four regions of massive star formation that illustrate different types of PDR boundaries. The Ara OB1 star formation region contains a striking long wall that has several wavy structures which are present in H2, but the emission is not particularly bright because the ambient UV fluxes are relatively low. In contrast, the Carina star formation region shows strong H2 fluorescence both along curved walls and at the edges of spectacular pillars that in some cases have become detached from their parent clouds. The less-spectacular but more well-known Eagle Nebula has two regions that have strong fluorescence in addition to its pillars. While somewhat older than the other regions, Cyg OB2 has the highest number of massive stars of the regions surveyed and contains many isolated, fluoresced globules that have head-tail morphologies which point towards the sources of ionizing radiation. These images provide a collection of potential astrophysical analogs that may relate to ablated interfaces observed in laser experiments of radiation hydrodynamics.
MN Lup: X-rays from a weakly accreting T Tauri star
Creators: name: Guenther, H. M.
name: Wolter, U.
name: Robrade, J.
name: Wolk, S. J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Young T Tauri stars (TTS) are surrounded by an accretion disk, which over time disperses due to photoevaporation, accretion, and possibly planet formation. The accretion shock on the central star produces an UV/optical veiling continuum, line emission, and X-ray signatures. As the accretion rate decreases, the impact on the central star must change. In this article we study MN Lup, a young star where no indications of a disk are seen in IR observations. We present XMM-Newton and VLT/UVES observations, some of them taken simultaneously. The X-ray data show that MN Lup is an active star with L_X/L_bol close to the saturation limit. However, we find high densities (n_e > 3e10 /cm^3) in the X-ray grating spectrum. This can be well fitted using an accretion shock model with an accretion rate of 2e-11 M_sun/yr. Despite the simple Halpha line profile which has a broad component, but no absorption signatures as typically seen on accreting TTS, we find rotational modulation in Ca II K and in photospheric absorption lines. In the Halpha line we see a prominence in absorption about 2R_* above the stellar surface - the first of its kind on a TTS. MN Lup is also the only TTS where accretion is seen, but no dust disk is detected that could fuel it. We suggest that MN Lup presents a unique and short-lived state in the disk evolution. It may have lost its dust disk only recently and is now accreting the remaining gas at a very low rate.
description: 13 pages, 7 figures, accepted by ApJ
CPT-Frames for PT-symmetric Hamiltonians
Creators: name: Cao, Huai-Xin
name: Guo, Zhi-Hua
name: Chen, Zheng-Li
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: PT-symmetric quantum mechanics is an alternative formulation of quantum mechanics in which the mathematical axiom of Hermiticity (transpose and complex conjugate) is replaced by the physically transparent condition of space-time reflection symmetry (PT-symmetry). A Hamiltonian H is said to be PT-symmetric if it commutes with the operator PT. The key point of PT-symmetric quantum theory is to build a new positive definite inner product on the given Hilbert space so that the given Hamiltonian is Hermitian with respect to the new inner product. The aim of this note is to give further mathematical discussions on this theory. Especially, concepts of PT-frames, CPT-frames on a Hilbert space and for a Hamiltonian are proposed, their existence and constructions are discussed.
Cyprinidae Schuster, Nelson, Grigarick and Christenberry
Creators: name: Marley, Nigel J.
name: Mcinnes, Sandra J.
name: Sands, Chester J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes

description: Order PARACHELA Schuster, Nelson, Grigarick and Christenberry  Cephalic papillae absent. Two, external and internal, claws per leg; each delineated into basal section, secondary branch and primary branch.
description: Published as part of Marley, Nigel J., Mcinnes, Sandra J. & Sands, Chester J., 2011, Phylum Tardigrada: A re-evaluation of the Parachela, pp. 51-64 in Zootaxa 2819 on page 58, DOI: 10.5281/zenodo.201757
On Lorentzian Connections with Parallel Skew Torsion
Creators: name: Ernst, Igor
name: Galaev, Anton
Publisher: name: Deutsche Mathematiker-Vereinigung
Year: 2022

description: DOCUMENTA MATHEMATICA, Vol 27 (2022), p. 2333-2383
description: DOCUMENTA MATHEMATICA, Vol 27 (2022), p. 2333-2383
description: The paper is devoted to metric connections with parallel skew-symmetric torsion in Lorentzian signature. This is motivated by recent progress in the Riemannian signature and by possible applications to supergravity theories. We provide a complete information about holonomy algebras, torsion and curvature of the considered connections up to the corresponding objects from the Riemannian signature. Various examples are constructed. It is shown how to construct all simply connected Lorentzian naturally reductive homogeneous spaces of arbitrary dimension from Riemannian naturally reductive homogeneous spaces. This leads to complete classification of Lorentzian naturally reductive homogeneous spaces in low dimensions.
description: DOCUMENTA MATHEMATICA, Vol 27 (2022), p. 2333-2383
Correspondence Between Classical and Quantum Theory by $f$-Deformed Coherent State
Creators: name: Roknizadeh, R.
name: Ghorashi, S. A. A.
name: Heydari, H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Generalized $f$-coherent state approach in deformation quantization framework is investigated by using a $\ast $-eigenvalue equation. For this purpose we introduce a new Moyal star product called $f$-star product, so that by using this ${\ast}_{f}$-eigenvalue equation one can obtain exactly the spectrum of a general Hamiltonian of a deformed system.
description: Presented in QTRF-6, June 11-14, 2012-Sweden
Prevalence and risk factors associated with self-reported carpal tunnel syndrome (CTS) among office workers in Kuwait.
Creators: name: Raman, Sudha R
name: Al-Halabi, Becher
name: Landry, Michel D
name: Hamdan, Elham
Publisher: name: BioMed Central Ltd
Year: 2012

description: AbstractBackgroundThe prevalence of carpal tunnel syndrome (CTS) is not well understood in many Arabian Peninsula countries. The objective of this study was to investigate the prevalence and factors associated with self-reported CTS in Kuwait.FindingsA cross-sectional, self-administered survey of CTS-related symptoms was used in this study. Multivariate logistic regression was also used to estimate adjusted odds ratios for factors of interest. Participants in this study were adult office workers in Kuwait (n = 470, 55.6% males), who worked in companies employing more than 50 people. Self-reported CTS was reported in 18.7% of the group (88/470). CTS was significantly associated with the following demographic factors: female gender, obesity and number of comorbid conditions. Self-identification of CTS was also associated with key symptoms and impairment in daily activities (e.g., wrist pain, numbness, weakness, night pain, difficulty carrying bags, difficulty grasping [Chi-Square Test for Association: P < 0.05 for all symptoms/activities]). However, symptoms such as wrist pain, weakness, and functional disabilities were also frequently reported among those who do not self report CTS (range: 12.1%–38.2%).ConclusionsPrevalence of self-reported CTS among office workers in Kuwait is 18.7%, and the risk factors for CTS in this population included female gender, obesity and number of related comorbidities. The frequency of symptoms in the sample who did not self report CTS suggest that CTS may be under-recognized, however further research is required to assess the prevalence of clinically diagnosed CTS.
Crataegus oxyacantha
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: C. Oxyacantha L. (Mespilus Oxyacantha Crantz) Cat. 140. Bis 1665m. l: Ob Evionnaz (J., Marietan); zwischen L'Epegnaz und Cocorier, bis 1650 m (F.); Outre-Rhone, bis 1665m (Garns). - 2: Ob Fully, 1160-1500m (Garns). (Gepflanzt in Hecken: Sitten [Chenevard].) Fehlt als urwüchsige Art. im Mittel- und Oberwallis sowie auf der Simplonsüdseite.
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Exploring Saudi Third Culture Kids’ Identity Development in Australia: A Narrative Approach
Creators: name: ALGHAMDI, ABDULRAHMAN MOSHREF S
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 470208
subject: Culture, representation and identity

description: This qualitative research study examines the sociocultural identity development of Saudi third culture kids living and studying in Australia. The study focuses on the challenges these children face in adapting to their host culture, including school, relationships, and navigating their Islamic and cultural identities. Four themes emerged: prioritising connections to Saudi heritage, experiencing culture shock from interactions with Australian society, recognising Victoria's multicultural society as supportive of faith practises, and blending Saudi cultural values with Australian values. The findings suggest that schools and educational policymakers can improve the learning needs of Saudi TCKs.
Novel therapies for resistant focal segmental glomerulosclerosis (FONT) phase II clinical trial: study design
Creators: name: Pinsk, Maury
name: Trachtman, Howard
name: Somers, Michael
name: Joy, Melanie
name: Vento, Suzanne
name: Savin, Virginia
name: Gassman, Jennifer
name: Greene, Tom
name: Gipson, Debbie
name: Wickman, Larysa
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background The lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in patients who fail to respond to corticosteroids and immunosuppressive therapies. Recent basic science advances have led to development of alternative treatments that specifically target aberrant pathways of fibrosis which are relevant to disease progression in FSGS. There is a need for a flexible Phase II study design which will test such novel antifibrotic strategies in order to identify agents suitable for phase III testing. Methods/Design The Novel Therapies for Resistant Focal Segmental Glomerulosclerosis (FONT) project is a multicenter Phase I/II RCT designed to investigate the potential efficacy of novel therapies for resistant FSGS. Adalimumab and galactose will be evaluated against conservative therapy consisting of the combination of lisinopril, losartan and atorvastatin. The sample size is defined to assure that if one of the treatments has a superior response rate compared to that of the other treatments, it will be selected with high probability for further evaluation. Comparison of primary and secondary endpoints in each study arm will enable a choice to be made of which treatments are worthy of further study in future Phase III RCT. Discussion This report highlights the key features of the FONT II RCT including the two-step outcome analysis that will expedite achievement of the study objectives. The proposed phase II study design will help to identify promising agents for further testing while excluding ineffective agents. This staged approach can help to prevent large expenditures on unworthy therapeutic agents in the management of serious but rare kidney diseases Trial Registration ClinicalTrials.gov, NCT00814255
Relative photometry of HAT-P-1b occultations
Creators: name: Béky, Bence
name: Holman, Matthew J.
name: Gilliland, Ronald L.
name: Bakos, Gáspár Á.
name: Winn, Joshua N.
name: Noyes, Robert W.
name: Sasselov, Dimitar D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present HST STIS observations of two occultations of the transiting exoplanet HAT-P-1b. By measuring the planet to star flux ratio near opposition, we constrain the geometric albedo of the planet, which is strongly linked to its atmospheric temperature gradient. An advantage of HAT-P-1 as a target is its binary companion ADS 16402 A, which provides an excellent photometric reference, simplifying the usual steps in removing instrumental artifacts from HST time-series photometry. We find that without this reference star, we would need to detrend the lightcurve with the time of the exposures as well as the first three powers of HST orbital phase, and this would introduce a strong bias in the results for the albedo. However, with this reference star, we only need to detrend the data with the time of the exposures to achieve the same per-point scatter, therefore we can avoid most of the bias associated with detrending. Our final result is a 2 sigma upper limit of 0.64 for the geometric albedo of HAT-P-1b between 577 and 947 nm.
description: 8 pages, 2 figures, 3 tables
Neue statistische Analysen zum Freispruch (nach Untersuchungshaft)
Creators: name: Kinzig, Jörg
name: Stelly, Wolfgang
Publisher: name: Universität Tübingen
Year: 2017
Subjects: subject: Deutschland
subject: Freispruch
subject: Empirische Forschung

description: Digitalisat weicht in der Seitenzählung vom Original ab
Entwicklung und Synthese allosterischer Hemmstoffe des Apicomplexa Bewegungs- und Invasionsapparates
Creators: name: Malcev, Dmitrij
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2019
Subjects: subject: Invasionshemmung
subject: Apicomplexa
subject: Malaria
subject: Myosine
subject: Carbazole
subject: Inhibitoren
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Die WHO-Agenda zur Malariaeradikation erfordert hohe Investitionen und das Anpassungspotential der Plasmodium-Parasiten betont den Bedarf an kontinuierlicher Entwicklung von neuen effektiven Ansätzen. Der unter allen Apicomplexa- Parasiten konservierte Fortbewegungs- und Invasionsapparat, das Glideosom, gemeinsam mit seinem zentralen Motorprotein Myosin A, stellt ein attraktives Ziel zur erfolgreichen Hemmung der parasitären Aktivität dar. In dieser Studie wurde die Erhöhung des Effektes eines potentiellen Myosin A-Inhibitors mit biarylischer Grundstruktur durch die Funktionalisierung der ortho-Position geprüft. Eine Reihe von ortho-substituierten Biarylen wurde aus den in silico durchgeführten Strukturmodifizierungen abgeleitet und synthetisiert. Die one-pot SUZUKI-MIYAURA-Kreuzkupplung mit angeschlossener Benzylierung lieferte einen effizienten Zugang zu den potentiellen Inhibitormolekülen. Titrierungsexperimente unter Quantifizierung des Effektes der Biaryle auf die ATPase-Aktivität des Myosin A-Modells über die mittlere inhibitorische Konzentration ergaben inhibitorische Aktivitäten der Substanzen im unteren mikrooder nanomolaren Bereich. Die Proliferation von nicht resistenten und multiresistenten Plasmodium falciparum Stämmen 3D7 und 7G8 wurde durch die Biaryle in vergleichbaren Konzentrationsbereichen effektiv gehemmt, wobei die Glideosomgesteuerten Prozesse der Erythrozyteninvasion und des Egress deutlich inhibiert wurden. In den in vitro Flashphotolyse-Experimenten wurden Biaryl-bedingte Veränderungen der Akto-Myosin-Kinetik und der ATP-Umsetzungsgeschwindigkeit, sowie eine starke Herabsetzung der Bindeaffinität des Myosin A-Modells zum ATP festgestellt. MD-Simulationen ergaben Interaktionen des veränderten Grundgerüstes im allosterischen Bereich der Aktininteraktion um das LYS274, die mit den in vitro Ergebnissen korrelieren und auf eine aktive Veränderung der allosterischen Kommunikation zwischen der Aktin- und Nukleotidbindestelle durch die Biaryle deuten. Der strukturbasierte Ansatz ermöglichte ebenfalls eine potentielle Erklärung für die selektive Aktivität des Carbazols DBC gegenüber Myosin-9b, während mehrere Isoformen von Myosinen der Klassen 1, 2 und 5 nicht beeinflusst wurden. Ensemblebasierten Dockings und beschleunigte MD-Simulationen deuten auf eine stabile Interaktion des DBC in einer spezifischen Bindestelle im Myosin-9b in der Nähe des Bindebereiches von Blebbistatin hin, die zur Störung der Motoraktivität führen kann. Die entsprechenden Bereiche der Myosine 1, 2 und 5 weisen eine niedrige Homologie zum Myosin-9b auf und sind durch DBC weniger populiert.
Globular clusters: equally old, but dynamically different
Creators: name: Lanzoni, Barbara
Publisher: name: Zenodo
Year: 2023

description: Galactic globular clusters share the same old age (~12 Gyr) but can be in very different stages of their internal dynamical evolution: some have only slightly modified their structure since formation (dynamically-young systems), while others have significantly increased their central density and already reached the core collapse phase (dynamically-old clusters). This is because the time-scale of internal dynamical evolution depends on many different factors, ranging from the initial mass and size of the cluster, to its primordial binary fraction, the population of black holes and neutron stars, and even the effect of an external tidal field. Hence, predicting the dynamical evolutionary stage of star clusters from first principles is unfeasible and the only solution is to find empirical diagnostics. In this talk I will describe two powerful methods based on the radial distribution of blue straggler stars and the central segregation of "normal" stellar populations, and discuss the main results obtained so far not only in the  Milky Way, but also out to the Magellanic Clouds.
Gulyaevilepis Kornienko & Binkiene 2014
Creators: name: Kornienko, Svetlana A.
name: Binkienė, Rasa
name: Dokuchaev, Nikolai E.
name: Tkach, Vasyl V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Cestoda
Cyclophyllidea
Hymenolepididae
Gulyaevilepis

description: GULYAEVILEPIS KORNIENKO & BINKIENė, 2014
Diagnosis (according to Kornienko & Binkienė, 2014): Small cestode with serial heteronomous maturation. Each series ends with one or two sterile proglottides. Proglottides acraspedote, wider than long, gravid longer than wide. Rostellum rudimentary. Suckers elongate, inside dorsal and ventral bothrium-like depressions of scolex. Osmoregulatory canals without transverse anastomoses. Three testes situated in a triangle, one poral and two antiporal. Cirrus armed. Internal seminal vesicles absent. External seminal vesicles elongate. Cirrus-sac reaches or slightly crosses midline of proglottis. Genital pores dextral. Vagina armed. Seminal receptacle indistinct. Ovary beanshaped, entire or slightly bilobed. Vitellarium entire. Uterus initially horseshoe-shaped, then transforms to become sacciform. European part of the Palaearctic.
Type and only species: Gulyaevilepis tripartita (Zarnowski, 1955) Kornienko & Binkienė, 2014.
Remarks: Besides male and hermaphroditic proglottides, G. tripartita has one or two sterile proglottides in each series of the strobila (Fig. 3B). The uterus transforms from horseshoe-shaped to sacciform without coalescence of the walls (Kornienko & Binkienė, 2014).
description: Published as part of Kornienko, Svetlana A., Binkienė, Rasa, Dokuchaev, Nikolai E. & Tkach, Vasyl V., 2019, Molecular phylogeny and systematics of cestodes with rudimentary rostellum (Cestoda: Hymenolepididae) from Holarctic Sorex shews (Eulipotyphla: Soricidae), pp. 965-986 in Zoological Journal of the Linnean Society 187 on page 979
Modeling of surface generation in contour grinding of optical molds
Creators: name: Heinzel, Carsten
name: Grimme, Daniel
Publisher: name: Elsevier
Year: 2006
Subjects: subject: Modeling
subject: Surface
subject: Grinding
subject: 620

description: The objective of this paper is the modeling of kinematics of precision contour grinding and resulting workpiece topography. Changes within the contact zone of grinding wheel and workpiece as well as speed ratios are analyzed and evaluated. The generated surface patterns caused by the runout of the grinding wheel are simulated. In the kinematic-geometrical model single grains on the peripheral surface of a grinding wheel, which interact with the workpiece, are considered. After describing the kinematics of the contour grinding process, changes in feed speeds and rotational speed ratios are examined and their effects on generated surfaces are simulated and compared with ground surfaces.
Comparision and analysis of photo image forgery detection techniques
Creators: name: Murali, S.
name: Chittapur, Govindraj B.
name: S, Prabhakara H.
name: Anami, Basavaraj S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Cryptography and Security (cs.CR)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Digital Photo images are everywhere, on the covers of magazines, in newspapers, in courtrooms, and all over the Internet. We are exposed to them throughout the day and most of the time. Ease with which images can be manipulated; we need to be aware that seeing does not always imply believing. We propose methodologies to identify such unbelievable photo images and succeeded to identify forged region by given only the forged image. Formats are additive tag for every file system and contents are relatively expressed with extension based on most popular digital camera uses JPEG and Other image formats like png, bmp etc. We have designed algorithm running behind with the concept of abnormal anomalies and identify the forgery regions.
description: 12 pages, International Journal on Computational Sciences & Applications (IJCSA) Vo2, No.6, December 2012
Adapting to New Needs in a Complex Research Environment
Creators: name: Richardson, Lee M.
name: Walker, Jennifer S.
name: Renner, Barbara Rochen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: At the request of deans of health sciences schools for increased librarian involvement in the research process, library leadership recognized librarians may not have the broad understanding of research necessary to provide optimal support at an R1 research intensive university. An online guide for librarians was developed to help address this.
Networks of free-living nematodes and co-extracted fungi, associated with symptoms of apple replant disease
Creators: name: Kanfra, Xorla
name: Wrede, Andreas
name: Mahnkopp-Dirks, Felix
name: Winkelmann, Traud
name: Heuer, Holger
Publisher: name: Amsterdam : Elsevier
Year: 2021
Subjects: subject: Apple replant disease
subject: Association network
subject: Disease complex
subject: Free-living nematodes
subject: Nematode community
subject: Nematode-microbe interaction
subject: Dewey Decimal Classification::600 | Technik::630 | Landwirtschaft, Veterinärmedizin
subject: Dewey Decimal Classification::600 | Technik::640 | Hauswirtschaft und Familienleben

description: Apple replant disease affects tree nurseries and apple production globally. After repeated planting in the same soil, apple roots show accumulation of phytoalexins, stunting, and blackening. Recently, we showed that nematodes extracted from replanted soil and co-extracted microbes triggered these symptoms, while pathogens or plant-parasitic nematodes could not explain the early disease development. To identify nematode-microbe complexes that coincide with replant disease, apple rootstocks were grown in the greenhouse in soils from five replanted sites for eight weeks. Nematodes were extracted by floatation from pots with stunted or normal plant growth, washed on a 20-μm sieve, and used for DNA extraction. Nematode communities and co-extracted fungi and bacteria were analyzed by high-throughput sequencing of amplified ribosomal fragments. The experiment was repeated in the next year. Regardless of soil type or year, the nematode and fungal communities significantly differed between pots with differential plant growth. Bacteria were not significantly associated with growth depression. Plant-parasitic nematodes or pathogens were not abundant in numbers that could explain the observed root damage. Free-living nematodes Prsimatolaimus, Acrobeles, Tylencholaimus, Acrobeloides, and Aphelenchus, and associated fungi Exophiala, Hohenbuehelia, Naganishia, Psathyrella, and unidentified members of Orbiliales, Helotiales, and Rhytismataceae significantly correlated with reduced plant growth. Isolating and investigating such disease complexes will give a chance to understand external biotic stress of apple roots and design mitigation measures. © 2021 The Authors
Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim
Creators: name: Takhar, Suchreet
name: Huang, Shuang
name: Dohn, Michael
name: Periyasamy-Thandavan, Sudharsan
name: Singer, Adam
name: Welborn, April
name: Marrero, Mario
name: Thangaraju, Muthusamy
name: LeRoith, Derek
name: Schoenlein, Patricia
name: Jackson, William
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Introduction In this pre-clinical in vitro study conducted in estrogen receptor positive (ER+) breast cancer cells, we have characterized the effects of insulin-like growth factor I (IGF-1) on the cytostatic and cytotoxic action of antiestrogen treatment when used as a single agent or in combination with the antiprogestin mifepristone (MIF). Our goal was to identify new molecular targets to improve the efficacy of hormonal therapy in breast cancer patients that have a poor response to hormonal therapy, in part, due to high circulating levels of unbound insulinIGF-1. Methods IGF-1-mediated effects on cytostasis and apoptotic cell death were determined with cell counts conducted in the presence and absence of trypan blue; enzyme-linked immunosorbent assays to determine the intracellular levels of cleaved cytokeratin 18, a marker of epithelial cancer cell apoptosis; and immunoblot analysis to determine the levels of cleaved poly-ADP ribose polymerase (PARP) and lamin A that result from caspase-dependent apoptosis. Cytotoxicity was further characterized by determination of the levels of reactive oxygen species (ROS) and the percent of mitochondrial membrane depolarization in cell populations treated with the different hormones in the presence and absence of IGF-1. Small molecule inhibitors of the dual-specificity protein kinase MEK1, MEK1 siRNA, Bim siRNA, and vectors overexpressing MEK1 wild type and mutant, dominant negative cDNA were used to identify key IGF-1 downstream prosurvival effectors. Results IGF-1, at physiologically relevant levels, blocked the cytotoxic action(s) of the antiestrogens 4-hydroxytamoxifen (4-OHT) and tamoxifen (TAM) when used as single agents or in combination with the antiprogestin MIF. The antiapoptotic action of IGF-1 was mediated primarily through the action of MEK1. MEK1 expression reduced the levels of ROS and mitochondrial membrane depolarization induced by the hormonal treatments via a mechanism that involved the phosphorylation and proteasomal turnover of the proapoptotic BH3-only Bcl-2 family member Bim. Importantly, small-molecule inhibitors of MEK1 circumvented the prosurvival action of IGF-1 by restoring Bim to levels that more effectively mediated apoptosis in ER+ breast cancer cells. Conclusion his study provides strong support for the use of MEK1 inhibitors in combination with hormonal therapy to effectively affect cytostasis and activate a Bim-dependent apoptotic pathway in ER+ breast cancer cells. We discuss that MEK1 blockade may be a particularly effective treatment for women with high circulating levels of IGF-1, which have been correlated to a poor prognosis.
Prevention of wheel clogging in creep feed grinding by efficient tool cleaning
Creators: name: Heinzel, Carsten
name: Antsupov, Grigory
Publisher: name: Elsevier
Year: 2012
Subjects: subject: Grinding
subject: Tool
subject: Cleaning
subject: 620

description: This paper is dealing with the identification of efficient cleaning nozzle configuration to prevent the wheel from loading in creep feed grinding. The properties of different cleaning nozzles types were analyzed in terms of jet velocity and jet impact on the wheel surface using high speed imaging and pressure sensitive sheets. In grinding experiments the cleaning efficiency of each nozzle configuration was evaluated by optical measurement of wheel clogging inside the machine tool. With this newly developed procedure of tool cleaning optimization a significant reduction of process forces (up to 30%) and of the tool wear (up to 20%) was achieved.
Does adsorption in a single nanogroove exhibit hysteresis?
Creators: name: Malijevsky, Alexandr
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A simple fluid, in a microscopic capillary capped at one end, is studied by means of fundamental measure density functional. The model represents a single, infinitely long nanogroove with long-range wall-fluid attractive (dispersion) forces. It is shown that the presence or absence of hysteresis in adsorption isotherms is determined by wetting properties of the wall as follows: Above wetting temperature, $T_w$, appropriate to a single wall of the groove, the adsorption is a continuous process corresponding to a rise of a meniscus from the capped to the open end of the groove. For a sufficiently deep capillary the meniscus rise is shown to be a steep, yet continuous process taking place near the capillary condensation of a corresponding slit. However, for temperatures lower than $T_w$ the condensation exhibits a first-order transition accompanied by hysteresis of the adsorption isotherm. Finally, it is shown that hysteresis may occur even for $T>T_w$ as a consequence of prewetting on the side and bottom walls of the groove.
Preliminary Investigation of Possible Biochar Use as Carbon Source in Polyacrylonitrile Electrospun Fiber Production
Creators: name: Schirra, Aaron
name: Ali, Annas Bin
name: Renz, Franz
name: Sindelar, Ralf
name: Pedrazzi, Simone
name: Allesina, Giulio
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: biochar
subject: carbon fibers
subject: gasification
subject: nanofibers
subject: polyacrylonitrile
subject: Dewey Decimal Classification::600 | Technik

description: Electrospinning with consequent thermal treatment consists in a carbon fiber production method that spins a polymer solution to create fibers with diameters around a few hundred nanome-ters. The thermal treatments are used for the cyclization and then carbonization of the material at 1700◦C for one hour. The unique structure of micro-and nano-carbon fibers makes them a promis-ing material for various applications ranging from future battery designs to filtration. This work investigated the possibility of using milled gasification biochar, derived from a 20 kW fixed-bed gasifier fueled with vine pruning pellets, as an addictive in the preparation of electrospinning solu-tions. This study outlined that solvent cleaning and the consequent wet-milling and 32 µm sifting are fundamental passages for biochar preparation. Four different polyacrylonitrile-biochar shares were tested ranging from pure polymer to 50–50% solutions. The resulting fibers were analyzed via scanning electron microscopy, and energy-dispersive X-ray and infrared spectroscopy. Results from the morphological analysis showed that biochar grains dispersed themselves well among the fiber mat in all the proposed shares. All the tested solutions, once carbonized, exceeded 97%wt. of carbon content. At higher carbonization temperatures, the inorganic compounds naturally showing in biochar such as potassium and calcium disappeared, resulting in an almost carbon-pure fiber matrix with biochar grains in between. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Radioskopie an schmelzflüssigen Metallen zur Prozeßoptimierung
Creators: name: Reichert, Christian
Publisher: name: Hannover : Universität
Year: 2001
Subjects: subject: Microfocus-radioscopy
subject: casting
subject: laser dispersing
subject: process optimization
subject: Dewey Decimal Classification::600 | Technik

description: [no abstract]