cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Non-surgical septal reduction therapy in hypertrophic obstructive cardiomyopathy: current practice and future potential
Creators: name: Cooper, Robert
Publisher: name: Imperial College London
Year: 2016

description: Obstruction in hypertrophic cardiomyopathy is associated with increased morbidity and mortality. Effective resolution of outflow tract obstruction can provide relief of symptoms and perhaps improve prognosis. Non-surgical septal reduction in the form of alcohol septal ablation (ASA) has been performed since 1994 with limited progress in the last decade. ASA using traditional methods has an unacceptably high rate of failure to resolve LVOT gradient. By creating and populating a relational database I was able to show that failure to treat LVOT gradient satisfactorily was seen in 41% after one procedure and 18% after multiple procedures. This can be partly explained by inaccurate location of the iatrogenic infarction, seen on CMR. Improving accuracy of infarction in ASA could be achieved by better peri-procedural imaging. Intracardiac echocardiography (ICE) provides excellent image quality of the contact point of the mitral valve on the septum in HOCM, but is no better than standard transthoracic echocardiography in describing detail of the septum or other cardiac structures relevant to ASA. ICE cannot see myocardial contrast well and therefore cannot be used to guide ASA alone. Computed tomography (CT) angiography can visualise small septal arteries. The ability to merge angiographic images with structural detail allows description of the path of arteries to guide alcohol injection in ASA. The use of CT planning improved the success rate of ASA after one procedure from 59% to 85%. We observed less RBBB (13% vs 62%) due to improved targeting of the LV septum, confirmed by CMR. Patient selection in ASA is important. A standard operating procedure for assessment and treatment of HOCM patients is now part of routine clinical care. Some patients cannot receive trans-coronary alcohol due to arterial anatomical restrictions. Direct endocardial radiofrequency ablation of the interventricular septum with merged ICE/CARTO electrophysiology mapping system guidance was explored with encouraging results.
title: Bridging Intimacy and Disability: A Mixed-Method Study on the Potential Use of Sex Tech for Neurodiverse Individuals and People with Disabilities
Creators: name: Mühl, Lisa
name: Szczuka, Jessica M.
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Disability
subject: Mixed-Method
subject: Sex Tech
subject: Sexuality
subject: Third-Person Effect

description: Background: Despite the universal human desire for touch, intimacy, and sexual pleasure, individuals with intellectual and physical disabilities as well as neurodiverse individuals often encounter barriers that impede their ability to fully engage in these aspects of life. A conspicuous gap persists in the scholarly exploration pertaining to how sexuality-related technologies could empower these individuals to assert their sexual needs and rights. Existing literature suggests that a prevailing assumption, largely held by non-disabled individuals, underscore the perceived appropriateness of such technologies primarily for ‘others’, specifically people with disabilities and neurodiverse individuals, but not for themselves.
Objective: Consequently, this study endeavors to advance the discourse surrounding the presumed appropriateness and suitability of sex tech, inducing sex toys, sexualized chatbots, and sex robots for vulnerable user groups. This inquiry will concurrently investigate the third-person effect as an underlying mechanism elucidating disparities in perception.
Method summary: A mixed-method approach is used to compare the perspectives of experts and non-experts. Thus, semi-structured interviews will be conducted to delve into experts’ perspectives on the appropriateness, chances, and barriers associated with sex tech. The quantitative study is designed to unravel the perspective on non-disabled, non-experts regarding the appropriate utilization of sex tech and their inclination towards self-usage. Additionally, social distance, perceived knowledge about sex tech, sexual conservatism, perceived stigma related to sex tech use as well as the gender of the participants will be included as covariates.
Conclusion: The study aims to underscore the necessity of more actively engaging both experts and those affected in research endeavors focused on vulnerable populations.
Additional file 5: of The use of low-cost Android tablets to train community health workers in Mukono, Uganda, in the recognition, treatment and prevention of pneumonia in children under five: a pilot randomised controlled trial
Creators: name: OâDonovan, James
name: Kabali, Kenneth
name: Taylor, Celia
name: Chukhina, Margarita
name: Kading, Jacqueline
name: Fuld, Jonathan
name: OâNeil, Edward
Publisher: name: figshare
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Demographic data. (PDF 57 kb)
Four-point boundary connectivities in critical two-dimensional percolation from conformal invariance
Creators: name: Gori, Giacomo
name: Viti, Jacopo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We conjecture an exact form for an universal ratio of four-point cluster connectivities in the critical two-dimensional $Q$-color Potts model. We also provide analogous results for the limit $Q\rightarrow 1$ that corresponds to percolation where the observable has a logarithmic singularity. Our conjectures are tested against Monte Carlo simulations showing excellent agreement for $Q=1,2,3$.
description: 29 pages, 9 Figures. Published version: improved discussion, additional numerical tests and references
title: 02_0323
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A metabonomics study of the modulation of lipid and bile acid metabolism by the gut microbiota and consequences on obesity and fatty liver disease
Creators: name: Sarafian, Magali
Publisher: name: Imperial College London
Year: 2016

description: Obesity and fatty liver disease are characterised by an imbalance between energy intake and energy expenditure. Genetic and environmental factors strongly contribute to impaired energy homoeostasis and can trigger metabolic disorders such as hypertension, hyperglycaemia and hypercholesterolemia which are associated with type 2 diabetes, cardiovascular diseases and metabolic syndrome. The mechanisms underpinning obesity and its co-morbidity are poorly understood but dysregulation of lipid metabolism is likely to contribute and can be studied by metabolic profiling using UPLC-MS. Moreover, the host-gut axis has a strong influence on obesity and fatty liver disease development by modulation of metabolic pathways. The analytical quality of the metabolic profiling methods is critical to understand the aetiopathogenesis of obesity. Hence the aim of this PhD project is to investigate lipid metabolism in obesity and fatty liver disease. I developed and optimised a strategy for characterising the global lipid profile of plasma based on isopropanol precipitation and supplemented this with the development of a targeted assay for obtaining in depth profile of bile acids (BAs) (n=145) since BAs are known to play a specific role in obesity and fatty liver disease. Furthermore, BAs can provide insight into the role of the gut microbiota in obesity as they are metabolised by the gut microbiota. The analytical pipeline for lipid and BA analysis are subsequently applied for two human clinical studies. i) The metabolic signatures associated with subcutaneous and visceral obesity were investigated. A significant increase of LPC (16:0), unconjugated BAs and sulphated BAs with a decrease of PC (16:0/20:3), taurine conjugates was observed in visceral obesity compared to subcutaneous obesity. ii) Subtle disease progression in fatty liver disease, NAFLD and NASH was evaluated. A significant increase of triacylglycerols, hyocholic acid and tauro-conjugated BAs with a decrease of phosphocholines were observed in NASH compared to NAFLD. This phD project illustrated that metabonomic instrumentations (UPLC-MS and UPLC-MS/MS) are non-invasive and powerful analytical techniques to diagnose obesity and fatty liver disease. In addition, metabonomic analysis of urine and blood samples may offer the possibility to optimise individual diagnosis and management of patients with obesity and fatty liver disease.
Sorex Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Soricomorpha
Soricidae
Sorex

description: Sorex [gen. nov.]
Dentes Primores Superiores II, bifidi.
Inferiores IV: intermediis 2 brevioribus.
Laniarii utrinque plures.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 53, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Fluid flow in multi-scale fracture networks: from field observation to numerical modelling
Creators: name: Wang, Xiaoguang
Publisher: name: Imperial College London
Year: 2016

description: This thesis investigates the hydrodynamic behaviour of fracture and karst networks with a specific focus on a major carbonate aquifer north of Montpellier, southern France. The study is based on an extensive database including fracture measurements collected on outcrops at various scales and hydrodynamic data recorded in boreholes at the Terrieu experimental site. A novel method was developed to predict the type and preferential location of incipient karst in layered joint networks. Results indicate that the aperture ratio between the bedding plane and joints controls the magnitude of flow localisation in the networks. The aperture ratio range for various karst types was also quantified. A 3D local-scale conceptual model of the field site was developed by integrating a detailed structural characterisation of fracture networks at multi-scale outcrops with a dynamic examination of flow path networks using borehole logging and well test data. Numerical flow simulations devised by an experimental design technique were used to systematically assess the feasibility of the conceptual model and quantify the effects of geometrical and hydraulic properties on the hydrodynamic behaviour. Results indicate that the borehole connectivity to different flow features dominates the borehole transient responses. The hierarchical flow behaviour observed in the field site can to some extent be captured by the predictive flow model; however, a complete match between the real and simulated data may require an improved characterisation of the highly heterogeneous and anisotropic transmissivity field. This issue was further addressed using inverse modelling approaches. A quasi-Newton approach was firstly applied to jointly invert the steady-state cross-hole pumping test data. From the inversions, distributions of flow channels in the Terrieu site were obtained. Results show that the flow anisotropy is consistent with the fracture anisotropy mapped from outcrops close to the test site. The manner of using the multiple dynamic datasets controls emergent local transmissivity contrast. In addition, bounds for local and regional transmissivities in the studied system were determined. A novel stochastic quasi-Newton algorithm was then applied to infer the local-scale spatial transmissivity field and to quantify the uncertainty associated with the inverse analyses. Results indicate that preconditioning the transmissivity field using rock type and borehole connection data is the key to finding a rational solution for high-dimensional inverse problems.
Dense Molecular Gas Associated with the Circumnuclear Star Forming Ring in the Barred Spiral Galaxy NGC 6951
Creators: name: Kohno, Kotaro
name: Kawabe, Ryohei
name: Vila-Vilaro, Baltasar
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present high resolution (3" - 5") observations of CO(1-0) and HCN(1-0) emission from the circumnuclear star forming ring in the barred spiral galaxy NGC 6951, a host of a type-2 Seyfert, using the Nobeyama Millimeter Array and 45 m telescope. We find that most of the HCN emission is associated with the circumnuclear ring, where vigorous star formation occurs. The HCN to CO integrated intensity ratio is also enhanced in the star forming ring; the peak value of HCN/CO ratio is 0.18, which is comparable to the ratio in the starbursts NGC 253 and M82. The formation mechanism of dense molecular gas has been investigated. We find that the shocks along the orbit crowding do not promote the formation of the dense molecular gas effectively but enhance the presence of low density GMCs. Instead, gravitational instabilities of the gas can account for the dense molecular gas formation. The HCN/CO ratio toward the Seyfert nucleus of NGC 6951 is a rather normal value (0.086), in contrast with other Seyferts NGC 1068 and M51 where extremely high HCN/CO value of ~ 0.5 have been reported.
description: 33 pages, 17 figures, to appear in the Astrophysical Journal
Additional file 2: of Quantifying forest structural diversity based on large-scale inventory data: a new approach to support biodiversity monitoring
Creators: name: Storch, Felix
name: Dormann, Carsten
name: Bauhus, Jürgen
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Transformation of variables into scores (between 0 and 1) based on variable-values of NFI2002 and literature; ‘-‘: threshold values from literature not available or (needed). (PDF 61 kb)
Angular analysis of the decay B$^+$ $\to$ K$^+μ^+μ^-$ in proton-proton collisions at $\sqrt{s} =$ 8 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The angular distribution of the flavor-changing neutral current decay B$^+$ $\to$ K$^+μ^+μ^-$ is studied in proton-proton collisions at a center-of-mass energy of 8 TeV. The analysis is based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 20.5 fb$^{-1}$. The forward-backward asymmetry $A_{\mathrm{FB}}$ of the dimuon system and the contribution $F_{\mathrm{H}}$ from the pseudoscalar, scalar, and tensor amplitudes to the decay width are measured as a function of the dimuon mass squared. The measurements are consistent with the standard model expectations.
description: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/BPH-15-001 (CMS Public Pages)
The contact electrogram and its architectural determinants in persistent human atrial fibrillation: understanding the electroarchitecture of the arrhythmic substrate
Creators: name: Qureshi, Norman
Publisher: name: Imperial College London
Year: 2016

description: The understanding of the underlying mechanisms of the persistence of atrial fibrillation remains poor. Key to this is the relationship between structure - myocardial architecture, and function - electrical activity, and how these can be measured, interpreted and correlated clinically. We sought to address the hypothesis that the local electrogram morphology is determined by local atrial myocardial activation patterns, which are in turn determined by local atrial myocardial architecture. In addressing this hypothesis, we utilised improved techniques of atrial segmentation and detection of wall enhancements to more accurately delineate underlying de novo atrial myocardial fibrosis, with late-gadolinium enhanced cardiac magnetic resonance imaging (LGE- CMRI). Here, we demonstrated a predilection of native structural remodelling on the posterior left atrial wall. The electrophysiological changes underlying late-gadolinium enhancements were interrogated with high-density electroanatomic 3D mapping using a Kernel as a unit of measure, in the varying rhythms of AF, sinus and pacing, with drop in tissue voltages and conduction velocities in regions of fibrosis, but counter-intuitively, a higher extent of electrogram fractionation in healthy myocardium. We observed the rate and wavefront-activation dependency of voltage, emphasizing the importance of voltage maps being interpreted in the context of its rhythm. We have also described a novel technique of AF voltage mapping, with the metric of mean AF voltage sampled over 8 secs correlating well with LGE-CMRI defined fibrosis, and surprisingly better than that of sinus rhythm voltage suggesting that this metric may be more representative of the underlying atrial substrate. Lastly, reverse translational cell monolayer experiments in novel co-cultured neonatal ventricular rat myocytes and fibroblasts were carried out to corroborate clinical in vivo observations under the control of the basic science laboratory. These emphasized the contributions of the structural and functional changes to electrogram morphology (voltage and fractionation). The contact electrogram is the result of a complex dynamic functional electrophysiology, and its interactions with the underlying atrial myocardium. This increased understanding of structure and function (electroarchitecture) provides mechanistic insights essential if we are to progress beyond the current empiricism of catheter ablation strategies of persistent AF.
Sorex araneus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Soricomorpha
Soricidae
Sorex
Sorex araneus

description: Sorex araneus [spec. nov.]
S. cauda corpore longiore.
Sorex. Faun. svec. 33. * Syst. nat. 10.
Mus araneus. Gesn. quadr. 741. Aldr. digit. 441. t. 442. Jonst. quadr. t. 66. Raj. quadr. 239.
Habitat in Europae cryptis.
Auriculae breves, amplae. Cauda longa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 53, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
The Topology of RR Lyrae Instability Strip and the Oosterhoff Dichotomy
Creators: name: Bono, G.
name: Caputo, F.
name: Marconi, M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Convective pulsating models with Y=0.24, stellar mass M=0.65Mo, 0.75Mo, under selected assumptions about luminosities and effective temperatures, are used together with stellar atmosphere computations to get the predicted dependence of RR Lyrae instability strip on stellar mass in the observative plane MV, B-V. The comparison with observed variables belonging to the globular clusters M3 and M15 is presented. It appears that in M3 (Oosterhoff type I) the transition between ab-type and c-type RR Lyrae takes place along the fundamental blue edge, whereas in M15 (Oosterhoff type II) it occurs near the first overtone red edge. This result supports the key role of the hysteresis mechanism originally proposed by van Albada & Baker for explaining the Oosterhoff dichotomy.
description: postscript file of 7 pages plus 3 figures and 2 tables. For any problem please write to marcella@astr1pi.difi.unipi.it
The development of a performance assessment methodology for CO2 storage sites using dynamic pressure and surface deformation data
Creators: name: De La Torre Guzman, Jorge
Publisher: name: Imperial College London
Year: 2015

description: A basic requirement for safe geological storage of CO2 is the ability and integrity of the storage complex to contain the CO2. However, the storage formation and the caprock may contain fractures and/or faults that could provide a permeable conduit for CO2 migration out of the prime storage formation. Furthermore, CO2 injection may induce or reactivate fracture networks and faults providing a pathway for CO2 leakage. Recent experience from large scale industrial CO2 storage projects have shown that the geomechanical response of structural features to CO2 injection is a critical parameter controlling the injection performance. The monitoring of the geomechanical response using InSAR surface deformation, injection pressure data and seismic data have provided valuable insight into CO2 injection and storage performance. There is, however, a need for greater integration between monitored data and numerical modelling techniques used to assess performance in order to establish the conformity of the actual behaviour of the injected CO2 with the modelled behaviour. Research presented in this thesis developed an integrated performance assessment methodology for CO2 storage sites, which incorporates satellite (InSAR) monitoring data, time-lapse seismic monitoring data, bottom hole pressure (BHP) data, inverse modelling, and coupled flow-geomechanical simulations using the ensemble Kalman filter (EnKF). The developed methodology has been applied to the In Salah CO2 storage field dataset in order to demonstrate its application and usefulness for the performance assessment of CO2 storage sites. First, an inversion scheme using Weiner filters based on a numerical geomechanical model was developed and used to invert InSAR surface deformation for reservoir pressure change. A forward coupled flow-geomechanical modelling study in conjunction with an InSAR and time-lapse seismic analysis was then performed. This lead to an improved understanding of the flow and pressure behaviour at one of the injection wells. Finally, an integrated approach combining inverse and forward modelling using the EnKF was developed and applied. The EnKF tool developed provides a framework for the updating of flow and geomechanical model parameters through the joint assimilation of bottom hole pressure and InSAR data.
On the accuracy of the HSE hybrid functional to describe many-electron interactions and charge localization in semiconductors
Creators: name: Flores, Mauricio A.
name: Orellana, Walter
name: Menéndez-Proupin, Eduardo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Hybrid functionals, which mix a fraction of Hartree-Fock (HF) exchange with local or semilocal exchange, have become increasingly popular in quantum chemistry and computational materials science. Here, we assess the accuracy of the Heyd-Scuseria-Ernzerhof (HSE) hybrid functional to describe many-electron interactions and charge localization in semiconductors. We perform diffusion quantum Monte Carlo (DMC) calculations to obtain the accurate ground-state spin densities of the negatively charged (SiV)$^-$ and the neutral (SiV)$^0$ silicon-vacancy center in diamond, and of the cubic silicon carbide (3C-SiC) with an extra electron. We compare our DMC results with those obtained with the HSE functional and find a good agreement between both methods for (SiV)$^-$ and (SiV)$^0$, whereas the correct description of 3C-SiC with an extra electron crucially depends on the amount of HF exchange included in the functional. Also, we examine the case of the neutral Cd vacancy in CdTe, for which we assess the performance of HSE against the many-body \emph{GW} approximation for the description of the position of the defect states in the band gap.
Measurement of differential cross sections for Z boson pair production in association with jets at $\sqrt{s} =$ 8 and 13 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: This Letter reports measurements of differential cross sections for the production of two Z bosons in association with jets in proton-proton collisions at $\sqrt{s} =$ 8 and 13 TeV. The analysis is based on data samples collected at the LHC with the CMS detector, corresponding to integrated luminosities of 19.7 and 35.9 fb$^{-1}$ at 8 and 13 TeV, respectively. The measurements are performed in the leptonic decay modes ZZ $\to\ell^+ \ell^- \ell'^+ \ell'^-$, where $\ell,\ell' =$ e, $μ$. The differential cross sections as a function of the jet multiplicity, the transverse momentum $p_\mathrm{T}$, and pseudorapidity of the $p_\mathrm{T}$-leading and subleading jets are presented. In addition, the differential cross sections as a function of variables sensitive to the vector boson scattering, such as the invariant mass of the two $p_\mathrm{T}$-leading jets and their pseudorapidity separation, are reported. The results are compared to theoretical predictions and found in good agreement within the theoretical and experimental uncertainties.
description: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/SMP-17-005 (CMS Public Pages)
Sorex cristatus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Soricomorpha
Soricidae
Sorex
Sorex cristatus

description: Sorex cristatus [spec. nov.]
S. naribus cristatis, cauda corpore breviore.
Habitat in Pensylvania. P. Kalm.
Facies Talpae, colore atro, palmis niveis.
Auriculae nullae. Rostrum longissimum. Cauda subnuda, corpore dimidio brevior, concolor. Nares singulae stella palmata radiis 10. s. 15. subulatis, nudis ut in Erinaceo. Dentes primores superiores 2; inferiores 4. Laniarii utrinque plures.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 53, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
General multilevel Monte Carlo methods for pricing discretely monitored Asian options
Creators: name: Kahale, Nabil
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computational Finance (q-fin.CP)
subject: FOS: Economics and business
subject: 91G60

description: We describe general multilevel Monte Carlo methods that estimate the price of an Asian option monitored at $m$ fixed dates. Our approach yields unbiased estimators with standard deviation $O(ε)$ in $O(m + (1/ε)^{2})$ expected time for a variety of processes including the Black-Scholes model, Merton's jump-diffusion model, the Square-Root diffusion model, Kou's double exponential jump-diffusion model, the variance gamma and NIG exponential Levy processes and, via the Milstein scheme, processes driven by scalar stochastic differential equations. Using the Euler scheme, our approach estimates the Asian option price with root mean square error $O(ε)$ in $O(m+(\ln(ε)/ε)^{2})$ expected time for processes driven by multidimensional stochastic differential equations. Numerical experiments confirm that our approach outperforms the conventional Monte Carlo method by a factor of order $m$.
description: 22 pages. Presented at the 35th Spring International Conference of the French Finance Association, May 2018
"UCHINCHI RENESSANS: INNOVATSIYA VA TADQIQOTLAR DAVRI"
Creators: name: IJODIY TO'PLAM
Publisher: name: Zenodo
Year: 2025

description: Bu ijodiy to‘plam ilm-fan, texnologiya va innovatsiyalar sohasidagi ilg‘or izlanishlar va yutuqlarga bag‘ishlangan. Mazkur to‘plam Uchinchi Renessans g‘oyasini ilmiy va amaliy jihatdan yoritib, zamonaviy dunyoda taraqqiyotga xizmat qilayotgan yangiliklar, tadqiqotlar va mualliflarning fikrlarini jamlagan. Unda texnologik inqilob, sun’iy intellekt, ilmiy yangiliklar va innovatsion g‘oyalar haqidagi maqolalar, tahlillar va kelajak prognozlari o‘rin olgan bo‘lib, fan va texnika rivojiga qiziquvchilar uchun qimmatli manba hisoblanadi.
title: 02_1091
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 2: of Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit
Creators: name: Boutron, Isabelle
name: Haneef, Romana
name: Yavchitz, Amélie
name: Baron, Gabriel
name: Novack, John
name: Oransky, Ivan
name: Schwitzer, Gary
name: Ravaud, Philippe
Publisher: name: figshare
Year: 2019
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Information and consent. (DOCX 256 kb)
Parton distributions from nonlocal chiral SU(3) effective theory. I. Splitting functions
Creators: name: Salamu, Y.
name: Ji, Chueng-Ryong
name: Melnitchouk, W.
name: Thomas, A. W.
name: Wang, P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a new formulation of pseudoscalar meson loop corrections to nucleon parton distributions within a nonlocal covariant chiral effective field theory, including contributions from SU(3) octet and decuplet baryons. The nonlocal Lagrangian, constrained by requirements of local gauge invariance and Lorentz-invariant ultraviolet regularization, generates additional interactions associated with gauge links. We use these to compute the full set of proton $\to$ meson + baryon splitting functions, which in general contain on-shell and off-shell contributions, in addition to $δ$-function terms at zero momentum, along with nonlocal contributions associated with the finite size of the proton. We illustrate the shapes of the various local and nonlocal functions numerically using a simple example of a dipole regulator.
description: 43 pages, 6 figures, version to appear in Phys. Rev. D
Additional file 3: of Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit
Creators: name: Boutron, Isabelle
name: Haneef, Romana
name: Yavchitz, Amélie
name: Baron, Gabriel
name: Novack, John
name: Oransky, Ivan
name: Schwitzer, Gary
name: Ravaud, Philippe
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Identification of news stories reported with spin. Search strategy. (DOCX 14 kb)
A study to investigate the immune response in ovarian cancer patients treated with chemotherapy
Creators: name: Datta, Shreelata
Publisher: name: Imperial College London
Year: 2016

description: Women with ovarian cancer usually present with advanced stage disease and, although sensitive to chemotherapy initially, the majority will relapse following first line treatment. Resistance to chemotherapy contributes to poor prognosis in ovarian cancer. A potential strategy to prolong the response to treatment and reduce chemotherapy resistance is immune based therapies. These therapies are likely to be most effective when disease is minimal or subclinical, such as at completion of first line chemotherapy, but depend on the ability to mobilize a sufficient immune response. Currently, little is known about the immune competence of ovarian cancer patients undergoing chemotherapy or upon its completion. The aim of this study was twofold. By measuring the cellular and humoral immune response to Hepatitis B vaccination we evaluated the immune competence of women once they had completed first-line chemotherapy for ovarian cancer. This provided important information about the optimal time of delivery and likely efficacy of future immune therapeutic strategies, suggesting a significant difference in B cell response between patients treated with chemotherapy and healthy age-matched control patients. A vaccine was used because it essentially replaces an initial infection but still leads to the generation of memory B cells. Secondly, by quantifying peripheral blood mononuclear cell levels of the immune checkpoint inhibitory receptor PD-1 (in lymphocytes) and its ligand, PD-L1 (in monocytes) in ovarian cancer patients undergoing and completing chemotherapy, this study investigated the possibility of using PD-1 and PD-L1 as a biomarker in ovarian cancer treatment. Our results found a significant difference in lymphocytic PD-1 T cell count between patients who had recently completed chemotherapy and those who had completed chemotherapy over a year ago. This suggests further work to characterize lymphocytic PD1 changes after chemotherapy treatment is warranted, to optimize the timing of the delivery of future immunotherapy.
Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance
Creators: name: Zhang, Xiaoqing
name: Ren, Xiaomei
name: Tang, Jiayin
name: Wang, Jiangtao
name: Zhang, Xiang
name: He, Peng
name: Yao, Chang
name: Bian, Weihe
name: Sun, Lizhu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-ε-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.
Additional file 4: of The use of low-cost Android tablets to train community health workers in Mukono, Uganda, in the recognition, treatment and prevention of pneumonia in children under five: a pilot randomised controlled trial
Creators: name: OâDonovan, James
name: Kabali, Kenneth
name: Taylor, Celia
name: Chukhina, Margarita
name: Kading, Jacqueline
name: Fuld, Jonathan
name: OâNeil, Edward
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Evaluation questionnaire. (PDF 33 kb)
Sorex aquaticus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Soricomorpha
Soricidae
Sorex
Sorex aquaticus

description: Sorex aquaticus [spec. nov.]
S. plantis palmatis, palmis caudaque corpore breviore albis.
Talpa virginianus niger. Seb. mus. 1. p. 51. t. 32. f. 3.
Habitat in America septentrionali. P. Kalm.
Facies praecedentis, sed cinerea aut fusca, palmis albis.
Cauda corpore quadruplo brevior, alba. Dentes primores superiores 2; inferiores 4: intermediis brevissimis. Laniarii utrinque plures, discreti.
Sorex capensis maximus Pet. gaz. 37. t. 23. f. 9. nobis non visus est.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 53, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 3: of Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction
Creators: name: Sébastien, Muriel
name: Benoit Giannesini
name: Aubin, Perrine
name: Brocard, Julie
name: Chivet, Mathilde
name: Pietrangelo, Laura
name: Boncompagni, Simona
name: Bosc, Christophe
name: Brocard, Jacques
name: Rendu, John
name: Gory-Fauré, Sylvie
name: Andrieux, Annie
name: Fourest-Lieuvin, Anne
name: Fauré, Julien
name: Marty, Isabelle
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S1. Gastrocnemius muscle bioenergetics assessed in vivo using 31P-MRS. (DOCX 15 kb)
Effect of Radiation Drag on Hoyle-Lyttleton Accretion
Creators: name: Nio, Tomomi
name: Matsuda, Takuya
name: Fukue, Jun
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Hoyle-Lyttleton type accretion is investigated, by taking account of not only the effect of radiation pressure but the effect of radiation drag. We calculate the trajectories of particles for three cases: only the effect of gravity is considered (case A); the effect of radiation pressure is taken into account (case B); the effect of radiation drag as well as radiation pressure is taken into account (case C). The accretion radii for former two cases are $2GM/v_{\infty}^2$ for case A and $2GM(1-Γ)/v_{\infty}^2$ for case B, where M is the mass of the accreted object, $v_{\infty}$ the relative velocity, and Gamma the normalized luminosity of the accreted object. We found that the accretion radius for case C is in between those of cases A and B under the present approximation; i.e., the accretion radius decreases due to radiation pressure while it increases due to radiation drag. In addition, the accretion radius for case C becomes larger as the incident velocity becomes fast. The effect of radiation drag becomes more and more important when the velocity of the incident particle is comparable to the light speed.
description: 11 pages, LaTeX with 6 eps figures, accepted by Publications of the Astronomical Society of Japan
'Constant in gain Lead in phase' element - Application in precision motion control
Creators: name: Saikumar, Niranjan
name: Sinha, Rahul Kumar
name: HosseinNia, S. Hassan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This work presents a novel 'Constant in gain Lead in phase' (CgLp) element using nonlinear reset technique. PID is the industrial workhorse even to this day in high-tech precision positioning applications. However, Bode's gain phase relationship and waterbed effect fundamentally limit performance of PID and other linear controllers. This paper presents CgLp as a controlled nonlinear element which can be introduced within the framework of PID allowing for wide applicability and overcoming linear control limitations. Design of CgLp with generalized first order reset element (GFORE) and generalized second order reset element (GSORE) (introduced in this work) is presented using describing function analysis. A more detailed analysis of reset elements in frequency domain compared to existing literature is first carried out for this purpose. Finally, CgLp is integrated with PID and tested on one of the DOFs of a planar precision positioning stage. Performance improvement is shown in terms of tracking, steady-state precision and bandwidth.
Pricing and risk sharing in incomplete markets
Creators: name: Crosby, Albert John
Publisher: name: Imperial College London
Year: 2015

description: We consider three topics. The topics are: Exact pricing of discretely-sampled variance derivatives (Chapter 2), No Good Deals - No Bad Models (Chapter 4) and Risk sharing in international economies and market incompleteness (Chapter 5). The unifying themes are: Incomplete markets, asset pricing and ambiguity aversion (or model uncertainty).
Kurtosis in Large-Scale Structure as a Constraint on Non-Gaussian Initial Conditions
Creators: name: Chodorowski, Michał J.
name: Bouchet, François R.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We calculate the kurtosis of a large-scale density field which has undergone weakly non-linear gravitational evolution from arbitrary non-Gaussian initial conditions. It is well known that the weakly evolved {\twelveit skewness} is equal to its initial value plus the term induced by gravity, which scales with the rms density fluctuation in precisely the same way as for Gaussian initial conditions. As in the case of skewness, the evolved {\twelveit kurtosis} is equal to its initial value plus the contribution induced by gravity. The scaling of this induced contribution, however, turns out to be qualitatively different for Gaussian versus non-Gaussian initial conditions. Therefore, measurements of the kurtosis can serve as a powerful discriminating test between the hypotheses of Gaussian and non-Gaussian nature of primordial density fluctuations.
description: uuencoded compressed tar file including postscript text (17 pages) and 2 postscript figures, submitted to MNRAS
Spinal injury in underbody blast
Creators: name: Spurrier, Edward James
Publisher: name: Imperial College London
Year: 2016

description: Improvised Explosive Device (IED) is common in insurgent conflict as such devices are cheap, available, and devastating. Recent literature shows that victims of these devices often have complex injuries including spinal fractures. However, spinal injuries are not described in detail, so the mechanism and effects of these injuries are not well understood. This thesis reviews the literature with respect to spinal injuries in blast and compares it to UK military victims of IED attacks with spinal fractures. In the UK population, the majority of spinal fractures are thoracolumbar and are associated with multiple other injuries. This thesis shows that, based on the patterns of injury in UK blast victims, most fractures are caused by a combination of axial loads and flexion, with the apex of the thoracic spine and the thoracolumbar junction most affected by flexion. Military vehicles incorporate features intended to reduce the effect of blast on their occupants, and a standardised test has been established to evaluate such designs. However, the simple model of the spine used for these tests lacks validity. Understanding the behaviour of the spine in blast incidents will support development of an improved injury prediction model for future vehicle design. In this thesis an in vitro study develops a model to understand the role of posture in shaping fracture patterns when the spine is loaded at the rates seen in blast, and supports the mechanistic propositions this thesis makes about the behaviour of the spine in underbody blast. The clinical outcome and functional effect of blast related spinal fractures is unknown. In a short case series, this thesis suggests that spinal fractures lead to significant pain but the effect of spinal injuries on function is unclear as these victims also have other severe injuries.