cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structural Determinants of Pannexin-1 Permeability to Cations and Lipids
Creators: name: Anderson, Connor Lindsay
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Neuroscience

description: Pannexin-1 (Panx1) is a large-pore ion and metabolite channel with broad cell/tissue expression, including neurons and glia of the central nervous system. Panx1 is best known for its efflux of adenosine 5’-triphosphate (ATP), contributing to a multitude of pathophysiological mechanisms. However, there is no shortage of molecular diversity amongst the molecules that permeate these channels under numerous signalling conditions. Recently, the Panx1 cryo-EM structures were reported, uncovering unique gating mechanisms and insights into its biophysics that will help better understand its physiology. Given that Panx1 is an attractive drug target based on its involvement in pathophysiological mechanisms like cancer, ischemic stroke, and inflammation, it is important to understand the entire scope of molecules that permeate these channels during these mechanisms. Evidence from our lab has suggested that Panx1 is permeable to the endocannabinoid, anandamide (AEA) and cation, calcium (Ca2+) under different physiological settings. This thesis explores the biophysical gating mechanisms of Panx1 by undergoing a targeted mutational profile of its structural domains we hypothesize are important in AEA or Ca2+ permeability. My over-arching hypothesis is that the signalling lipid, AEA and cation, Ca2+ are permeants of Panx1. This thesis shows that in vitro Panx1 expression increases the uptake of a fluorescent AEA compound. Additionally, I identify key domains and residues that when mutated, create switch-of-function characteristics where a decrease in ion permeability results in increased AEA permeability and vice-versa. I propose that Panx1 rapidly switches between ion and AEA conducting states. Furthermore, I show that Panx1 is weakly permeable to cations and that mutagenesis of the Panx1 selectivity filter does not increase Ca2+ permeability. In conclusion, the work presented in this thesis has identified unique structural features of Panx1 that mediate the direct flux of AEA across the plasma membrane. Additionally, the structural domains that convey ion/size selectivity do not permit Ca2+, giving reason to believe that secondary signalling characteristics may give rise to this putative Panx1 function. Overall, this thesis uncovers a novel functionality of Panx1 that will have implications for its drug development and contributions to cellular physiology.
Additional file 1: of Exosomal TRIM3 is a novel marker and therapy target for gastric cancer
Creators: name: Fu, Hailong
name: Yang, Huan
name: Zhang, Xu
name: Wang, Bo
name: Mao, Jiahui
name: Li, Xia
name: Wang, Mei
name: Zhang, Bin
name: Sun, Zixuan
name: Qian, Hui
name: Xu, Wenrong
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Table S1. Sequences of TRIM3-siRNA. (DOCX 18 kb)
On achieving size-independent stability margin of vehicular lattice formations with distributed control
Creators: name: Hao, He
name: Barooah, Prabir
Publisher: name: arXiv
Year: 2011
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Optimization and Control (math.OC)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study the stability margin of a vehicular formation with distributed control, in which the control at each vehicle only depends on the information from its neighbors in an information graph. We consider a D-dimensional lattice as information graph, of which the 1-D platoon is a special case. The stability margin is measured by the real part of the least stable eigenvalue of the closed-loop state matrix, which quantifies the rate of decay of initial errors. In [1], it was shown that with symmetric control, in which two neighbors put equal weight on information received from each other, the stability margin of a 1-D vehicular platoon decays to 0 as O(1/N^2), where N is the number of vehicles. Moreover, a perturbation analysis was used to show that with vanishingly small amount of asymmetry in the control gains, the stability margin scaling can be improved to O(1/N). In this paper, we show that, with judicious choice of non-vanishing asymmetry in control, the stability margin of the closed loop can be bounded away from zero uniformly in N. Asymmetry in control gains thus makes the control architecture highly scalable. The results are also generalized to D-dimensional lattice information graphs that were studied in [2], and the correspondingly stronger conclusions than those derived in [2] are obtained. In addition, we show that the size-independent stability margin can be achieved with relative position and relative velocity (RPRV) feedback as well as relative position and absolute velocity (RPAV) feedback, while the analysis in [1], [2] was only for the RPAV case.
description: Accepted to IEEE Transactions on Automatic Control
A semi-discrete finite element method for a class of time-fractional diffusion equations
Creators: name: Sun, HongGuang
name: Chen, Wen
name: Sze, K. Y.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: As fractional diffusion equations can describe the early breakthrough and the heavy-tail decay features observed in anomalous transport of contaminants in groundwater and porous soil, they have been commonly employed in the related mathematical descriptions. These models usually involve long-time range computation, which is a critical obstacle for its application, improvement of the computational efficiency is of great significance. In this paper, a semi-analytical method is presented for solving a class of time-fractional diffusion equations which overcomes the critical long-time range computation problem of time fractional differential equations. In the procedure, the spatial domain is discretized by the finite element method which reduces the fractional diffusion equations into approximate fractional relaxation equations. As analytical solutions exist for the latter equations, the burden arising from long-time range computation can effectively be minimized. To illustrate its efficiency and simplicity, four examples are presented. In addition, the method is employed to solve the time-fractional advection-diffusion equation characterizing the bromide transport process in a fractured granite aquifer. The prediction closely agrees with the experimental data and the heavy-tail decay of anomalous transport process is well-represented.
description: 24 pages, 7 figures
Personal data protection in the Vatican City State: Views on the applicability and enforceability of Italian data protection legislation
Creators: name: Morelli, Dario
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Santa Sede e Città del Vaticano

description: Article subjected to peer review
SUMMARY: 1. General framework of the applicability of Italian legislation within the Vatican City State - 2. The right to privacy under European and canon law - 3. Applicability and enforceability of the Italian Data Protection Code within the Vatican City State.
Abstract: In the Vatican City State no specific laws have been adopted either by the Supreme Pontiff, the Pontifical Commission, or other legitimate Vatican City State authorities in relation to the fundamental right to privacy of natural and legal persons. Canon 220 of the Code of Canon Law refers to the protection of a good reputation and of intimitas, but does not provide for specific or self-contained rules related to personal data protection; it contains only general principles that can (and should) be articulated in more specific regulations. Therefore, it seems feasible that the provisions of the Italian Data Protection Code concerning the processing of personal data and the protection of privacy in the telecommunications sector - as well as any other provision concerning the sector of telecommunications and relevant services, both of landline and mobile networks, in their entirety - should be automatically applicable within the Vatican City State, pursuant to Article 12.1.a.5 of Law no. LXXI on the sources of law of the Vatican City State.
Keywords: personal data protection, intimitas, Vatican City State, sources of law
description: Stato, Chiese e pluralismo confessionale, 2012: 5 novembre
L’impercettibile confine a quasi venticinque anni dalla sentenza n. 203 del 1989 della Corte costituzionale
Creators: name: Tavani, Angela Patrizia
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Laicità e pluralismo

description: Il contributo, sottoposto a valutazione, è destinato alla pubblicazione negli Atti del Convegno di studio organizzato dall’ADEC sul tema “Dimensione pubblica e fattore religioso – Stato attuale e prospettive” (Bari, Aula Magna “Aldo Moro”, 17-18 settembre 2009), in corso di stampa
SOMMARIO: 1. La posizione del Presidente della Repubblica Giorgio Napolitano – 2. Laicismo e anticlericalismo – 3. Un’auspicabile prospettiva circa la laicità.
ABSTRACT An event that has sparked discussions on neutrality and assumed centrality in the debate on the public dimension of the religious factor is related to the non-participation of Benedict XVI at the inauguration of the academic year at the University of Rome "La Sapienza", scheduled for January 17, 2008. In its judgment no. 203/1989, the Constitutional Court stated that neutrality "does not imply indifference to religion but the state guarantee for the protection of freedom of religion, under the religious and cultural pluralism." The debate on the issue of the University "La Sapienza" has fueled confusion about the meaning of the word to make the invisible boundary between neutrality, laicism and anti-clericalism. Decisive contribution to the construction of some carefully sentinels, among which there are those who have authoritatively explained that neutrality is to be understood: "... not as an attitude of estrangement, indifference or hostility of the state and its elites, with respect to the religious consciousness of the people, under the confessional pluralism, atheism is not excluded, but the protection of the equal freedom of all faiths (...) The true neutrality and the true faith are made to compete fairly in the conduct man to the full meaning of the days that are given to live".
KEYWORDS: Neutrality, public dimension of the religious factor, laicism, anti-clericalism
description: Stato, Chiese e pluralismo confessionale, 2012: 5 novembre
Perinatal outcomes in multiple sclerosis
Creators: name: Lu, Ellen Meng-I
Publisher: name: University of British Columbia
Year: 2013

description: Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system, affecting many adults of childbearing age. Although extensive research has examined the association between MS and traditional perinatal outcomes (i.e. cesarean section, birth weight and preterm birth), other important outcomes are understudied, partly due to existing methodological challenges. Using comprehensive populationbased databases including the British Columbia (BC) MS Database, BC Perinatal Database Registry, Vital Statistics Birth Registry, Population Data BC Consolidation File and Census GeoData, this dissertation investigated the association between MS (and related clinical factors) with: labour induction and augmentation; obstetrical epidural and spinal anesthesia; length of birth hospitalization in mothers and their newborns; as well as birth outcomes in fathers with MS. Overall, individuals with MS were not at increased risk for the investigated outcomes compared to the general population with the exception that multiparous women with MS had higher rates of epidural anesthesia compared to multiparous women in the general population. Within MS women, those with longer disease duration had less epidural anesthesia and those with greater disability had more labor induction. Men with greater MS disability tended to father offspring with lower mean birth weight, but their newborns were still within the normal range for the general population. Individuals with MS who wish to have children must also decide between initiating disease-modifying drug (DMD) early to minimize relapses (i.e. MS attacks) or delaying/stopping therapy prior to conception to avoid potential fetal harm from in utero DMD exposure. This dissertation explored perinatal outcomes in women and men with iii MS exposed to DMDs and includes a systematic review of DMD exposure on perinatal outcomes. Data from BC suggest that DMD exposure in men and women with MS does not increase the risk of unfavorable perinatal outcomes. However, best evidence from the systematic review indicates that interferon-beta exposure in women with MS is associated with preterm birth, lower mean birth weight and shorter mean birth length in newborns; nonetheless, growth parameters of exposed newborns remained within normal values for the general population and preterm births tended to be close to term.
Sana laicità o laicità positiva?
Creators: name: Dalla Torre, Giuseppe
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Laicità e pluralismo

description: Il saggio, accettato dal Direttore, è destinato agli Studi in onore del Cardinale Zenon Grocholewski.
SOMMARIO: 1. Per superare la polisemia del termine “laicità” - 2. Cenni sulla dottrina cattolica in tema di laicità - 3. Una aggettivazione risalente: la “sana” laicità - 4. Le più moderne espressioni della “laicità positiva” - 5. Note conclusive
description: Stato, Chiese e pluralismo confessionale, 2012: 12 novembre
On Solvent-Rich Recovery Processes
Creators: name: Liu, Jianbo
Publisher: name: Schulich School of Engineering
Year: 2023
Subjects: subject: Heavy oil
subject: Solvent recovery
subject: Asphaltene precipitation
subject: Solubility
subject: Emulsion
subject: Bitumen
subject: Asphaltene deposition
subject: Engineering--Petroleum
subject: Engineering--Chemical

description: Current steam-based recovery processes such as Steam-Assisted Gravity Drainage (SAGD) are very effective at recovering bitumen (extra heavy oil) from oil sands reservoirs but these recovery processes have significant emissions making bitumen among the most emission intensive oils globally. Solvent-based recovery processes are one option that would lower the emissions intensity of oil sands recovery yielding a potentially upgraded oil product to the surface leaving a fraction of the asphaltenes and sulphur within the reservoir. This would not only be beneficial for upstream emissions reduction but also for downstream processing emissions since there would be less petroleum coke and sulphur generated in the upgrading and refining of the upgraded oil product. However, there are many uncertainties for solvent-based recovery processes that render it a challenge to move these processes forward commercially. The research in this thesis is different than other research – it attempts to examine the solvent-based processes and the connected physical phenomena including solvent solubility, viscosity reduction in dilution, onset of asphaltene precipitation and onset of asphaltene depostion, viscosity of the upgraded oil after asphaltene precipitation, W/O emulsions in bitumen and the effect of solvent on emulsions, and an examination of the performance of solvent-based recovery processes in two-dimensional prototypical physical model experiments in a holistic manner, for the first time. The results provide new data on asphaltene, the impact of solvent dilution on viscosity before and after asphaltene precipitation onset, new solubility data, new insights from rich-solvent Hele-Shaw gravity drainage experiments, and effect of solvent on emulsions. The outcomes provide a basis for optimized design of the solvent-based recovery processes.
More on the O(n) model on random maps via nested loops: loops with bending energy
Creators: name: Borot, G.
name: Bouttier, J.
name: Guitter, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We continue our investigation of the nested loop approach to the O(n) model on random maps, by extending it to the case where loops may visit faces of arbitrary degree. This allows to express the partition function of the O(n) loop model as a specialization of the multivariate generating function of maps with controlled face degrees, where the face weights are determined by a fixed point condition. We deduce a functional equation for the resolvent of the model, involving some ring generating function describing the immediate vicinity of the loops. When the ring generating function has a single pole, the model is amenable to a full solution. Physically, such situation is realized upon considering loops visiting triangles only and further weighting these loops by some local bending energy. Our model interpolates between the two previously solved cases of triangulations without bending energy and quadrangulations with rigid loops. We analyze the phase diagram of our model in details and derive in particular the location of its non-generic critical points, which are in the universality classes of the dense and dilute O(n) model coupled to 2D quantum gravity. Similar techniques are also used to solve a twisting loop model on quadrangulations where loops are forced to make turns within each visited square. Along the way, we revisit the problem of maps with controlled, possibly unbounded, face degrees and give combinatorial derivations of the one-cut lemma and of the functional equation for the resolvent.
description: 40 pages, 9 figures, final accepted version
E ET TH HI IO OP PI IA AN N  J JO OU UR RN NA AL L  O OF F  E EC CO ON NO OM MI IC CS S  VOLUME XVIII
Creators: name: Naill Kishtany And Alemayehu Seyoum Taffesse
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2009

description: No abstract available for this resource
I progetti per l’introduzione del divorzio in Italia in epoca post-unitaria
Creators: name: Franceschi, Fabio
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Famiglia

description: Contributo sottoposto a valutazione.
SOMMARIO: 1. Premessa – 2. Cenni sulla legislazione matrimoniale nell’Italia preunitaria – 3. L’introduzione del matrimonio civile nella codificazione unitaria del 1865 e la questione del divorzio – 4. I primi fermenti divorzisti: i progetti Morelli (1878-1880) – 5. Il progetto Villa del 1881 – 6. Il progetto Zanardelli del 1883 – 7. Il divorzio sul finire del XIX secolo: un problema aperto – 8. Il secondo progetto Villa (1892) – 9. Il terzo progetto Villa (1892-1893) – 10. L’inizio del nuovo secolo e il rinnovato entusiasmo divorzista. Il progetto Berenini-Borciani (1901) – 11. Il progetto Zanardelli-Cocco Ortu (1902) – 12. Il divorzio nel periodo giolittiano e il progetto Comandini (1914) – 13. Il progetto Marangoni-Lazzari (1920): fine di un’epoca – 14. Considerazioni conclusive.
description: Stato, Chiese e pluralismo confessionale, 2012: 12 novembre
Synthetic modifications of guest host properties in calix[6]arenes
Creators: name: Vandel, Mason Sheldon
Publisher: name: University of British Columbia
Year: 2013

description: This project investigated the synthesis and characterization of several calix[6]arene azo dyes and attempts to link calix[6]arenes with terpyridine moieties with various alkyl chains. Mass spectrometry was used to confirm the presence of the fully substituted dyes as well as several partially substituted calix[6]arenes. ¹H NMR spectroscopy was used to propose a possible conformation of one of the calix[6]arene dyes as well as characterize several allyl substituted calix[6]arenes. NMR studies were also used to identify the product of a Mitsunobu cross coupling reaction between calix[6]arene and terpyridine.
I diversi modelli di finanziamento pubblico: uno sguardo d’insieme
Creators: name: Pistolesi, Ingrid
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Confessioni religiose

description: Il contributo, sottoposto a valutazione, riproduce, con l’aggiunta delle note, il testo della relazione svolta al Convegno organizzato dall'Istituto Internazionale di Diritto canonico e diritto comparato delle religioni della Facoltà di Teologia di Lugano sul tema “Il finanzamento pubblico delle Chiese: sguardi incrociati tra Svizzera ed Europa” (Lugano, 13-14 settembre 2012), ed è destinato alla pubblicazione negli Atti.
SOMMARIO: 1. Premessa – 2. Il sistema dell’imposta ecclesiastica – 3. L’assegnazione di una quota del gettito fiscale – 4. Erogazioni dirette a favore delle confessioni religiose - 5. Conclusioni.
description: Stato, Chiese e pluralismo confessionale, 2012: 12 novembre
title: Breast Fat Necrosis: clinical and imaging findings
Creators: name: Carmona, Maria
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Trauma
subject: Inflammation
subject: Biopsy
subject: Ultrasound
subject: MR
subject: Mammography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Our purpose is to describe the clinical presentation,to review the findingsin different imaging modalities including mammography, ultrasound, and magnetic resonance, andtoevaluate the management of fat necrosis in the...
Successful attack on permutation-parity-machine-based neural cryptography
Creators: name: Seoane, Luís F.
name: Ruttor, Andreas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cryptography and Security (cs.CR)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: An algorithm is presented which implements a probabilistic attack on the key-exchange protocol based on permutation parity machines. Instead of imitating the synchronization of the communicating partners, the strategy consists of a Monte Carlo method to sample the space of possible weights during inner rounds and an analytic approach to convey the extracted information from one outer round to the next one. The results show that the protocol under attack fails to synchronize faster than an eavesdropper using this algorithm.
description: 4 pages, 2 figures; abstract changed, note about chaos cryptography added, typos corrected
Lower Bounds for Bruss' Odds Problem with Multiple Stoppings
Creators: name: Matsui, Tomomi
name: Ano, Katsunori
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We give asymptotic lower bounds of the value for Bruss' optimal stopping problem with multiple stopping chances. It interestingly consists of the asymptotic threshold values in the optimal multiple stopping strategy. Another interesting implication of the result is that the asymptotic value for each secretary problem with multiple stoppings is in fact a typical lower bound in a much more general class of multiple stopping problems as modifications of odds problem.
description: 41 pages, 4 figures
Network Slicing and Resource Allocation in Cloud Radio Access Networks
Creators: name: Shirzad, Fatemeh
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Radio Access Network Slicing
subject: Cloud Radio Access Network
subject: Radio Access Network Virtualization
subject: Wireless Resource Allocation
subject: Education--Sciences

description: Wireless networks based on 5G and beyond 5G technologies are required to support high data traffic demand and diverse service requirements, such as different delay or throughput requirements. Radio Access Network (RAN) slicing has been introduced to address these requirements by virtualizing and sharing the network resources among multiple service providers (SP), which has gained significant attention in recent years. However, most of the current studies are on traditional decentralized network architectures where distributed base stations manage their resources independently from each other, leading to energy and cost inefficiency. We investigate RAN slicing in Cloud Radio Access Networks (C-RAN) as a centralized architecture for virtualizing and sharing the baseband computing resources among several Remote Radio Heads. From the perspective of slicing granularity, the existing solutions are categorized into two groups, user-level and SP-level slicing. In the former, the resources are allocated in small granularity and directly to end-users from all SPs, resulting in higher utilization of resources. In the latter, resources are allocated in bulk to different SPs, resulting in more isolated slices. We study three problems by considering different types of resources in C-RAN and different levels of slicing. First, we consider spectrum resource slicing, where the problem is modeled as a multiple knapsacks with assignment restriction problem, and several heuristic algorithms are proposed to solve it. Then, we investigate RAN slicing in joint transmission (an advanced technique in 5G to increase user data rate) based C-RANs. Taking a user-level slicing approach, we formulate the problem as a sum-rate maximization problem, and a successive convex approximation-based algorithm is proposed to solve it. In the third problem, we study RAN slicing in C-RAN with Multi-access Edge Computing capability, where computation-intensive tasks are offloaded to edge servers. A machine learning-based and user-level slicing framework is proposed to slice the resources among SPs intelligently and efficiently. In this work, the resource allocation decisions are made in multiple stages, rather than a onetime decision-making framework in the existing studies, resulting in higher resource utilization and success rate for requests as evidenced by simulation studies.
Sur la reconnaissance de la compétence exclusive des groupements religieux afin d‘instaurer leur structure intrinsèque et les normes intérieures des relations en tant qu’une des garanties ...
Creators: name: Ryabykh, Philip
name: Ponkin, Igor
name: Ponkina, Alena
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Lavoro

description: Version étendue de la déclaration de l'Eglise orthodoxe russe, en tant que tierce partie dans l’affaire «Syndicat “Le Bon Pasteur” c. Roumanie» (requête 2330/09), envoyée à la Grande Chambre de la Cour européenne des droits de l'homme
SOMMAIRE: 1. Brève histoire de l’affaire – 2. Préambule – 3. Protection de la compétence exclusive des groupements religieux en vue d’instaurer leur structure intrinsèque et les normes intérieures des relations au point de vue de la législation de la Roumanie – 4. Application du principe de l’autonomie des groupements religieux et du principe de l’inadmissibilité d’intervenir pour l’État aux affaires intérieures des groupements religieux – 5. Non-contradiction de la Convention des exigences intérieures des groupements religieux sur la loyauté et la conformité des personnes se trouvant dans les relations de service avec le groupement religieux – 6. Absence des raisons fournies par les faits juridiques suffisantes et justifiant réellement l’assimilation (la mise au même niveau) des groupements religieux avec n’importe quelles autres organisations-employeurs dans la sphère de la réglementation des relations de travail – 7. Légalité de l’instauration des restrictions à la création et les activités des syndicats dans les certaines sphères des relations publiques – 8. Compétence de la Roumanie de fixer dans la législation les restrictions à la liberté des syndicats conformément à la sphère des relations religieuses – 9. Signification des résultats du jugement de l’affaire «Syndicat “Le Bon Pasteur” c. Roumanie» (requête 2330/09) pour L’Église Orthodoxe Russe- 10. Conclusion.
description: Stato, Chiese e pluralismo confessionale, 2012: 12 novembre
Enti religiosi e fund raising: un binomio possibile (anzi, necessario)
Creators: name: Franceschi, Fabio
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Enti ecclesiastici

description: Contributo sottoposto a valutazioni
SOMMARIO: 1. Premessa - 2. Il fund raising: inquadramento concettuale - 3. (segue) Strategie, strumenti e tecniche di fund raising - 4. Il fund raising come fattore di potenziale sviluppo delle organizzazioni non profit - 5. Enti religiosi e fund raising: un binomio che necessita di essere consolidato (e potenziato) - 6. Peculiarità dell’azione di fund raising degli enti religiosi - 7. Fund raising e aspetti economici e gestionali degli enti religiosi - 8. Considerazioni conclusive.
Abstract:
Religious organizations and fundraising: a possible combination (indeed necessary) Fund-raising activities represent the principal livelihood and sources of growth and development for non-profit organisations. Fund-raising is, also, an increasingly important part of religious organizations life. Almost each of them engages in some kind of fund-raising activity, with the purpose of generating income to sustain the organization’s programs and activities. The present study analyzes the relationship between religious organizations and fund-raising activities: a correlation that always existed, but now calls for consolidation and improvement in order to allow religious organizations to achieve economic sustainability. Therefore, religious organizations should develop competency and capacity to design and implement fund-raising activities, through appropriate policies, tools and methodologies. In this perspective, the author examines all the facets of fund-raising activities related to the religious organizations sector and, more in general, the possible applications of business administration principles to the management of religious bodies (so-called “church management”).
Parole chiave: enti religiosi; fund raising; sostenibilità economica; management
description: Stato, Chiese e pluralismo confessionale, 2012: 19 novembre
The role of cancer and non-cancer cell infections in systemic VSV∆M51 therapy
Creators: name: Rajwani, Jahanara
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Oncolytic viruses
subject: Cancer Immunotherapy
subject: Vesicular stomatitis virus
subject: Host-pathogen interactions
subject: Virology
subject: Immunology
subject: FOS: Clinical medicine
subject: Oncology

description: Oncolytic viruses (OVs) such as Vesicular stomatitis virus (VSV∆M51) have been built to selectively kill cancer cells while eliciting potent antitumour immune responses. However, the mechanisms by which VSV∆M51 induces antitumour immunity are poorly understood. We employed intravital microscopy to study the association between cancer cell infection and tumour regression in multiple mouse tumour models. Surprisingly, we found that several tumours showing little evidence of cancer cell infection underwent complete regression. To investigate this further, I engineered VSV∆M51 infection-resistant tumour lines by knocking out the low-density lipoprotein receptor (LDL-R) gene family, known as the entry receptor for several oncolytic rhabdoviruses. Interestingly, mice bearing infection-resistant tumours still responded to VSV∆M51 therapy, suggesting that cancer cell infection is not required for therapeutic outcome. I then focused on understanding how VSV∆M51 elicits antitumour immunity in infection-resistant tumours. I found that VSV∆M51 treatment improved antigen presentation in the tumour draining lymph node (TdLN), since treating mice bearing mCherry+ tumours with VSV∆M51 induced migration of mCherry+ dendritic cells (DCs) to the TdLN. This migration was partially dependent on the systemic release of cytokines from the spleen, as VSV∆M51-induced DC recruitment to lymph nodes was attenuated in splenectomized mice. Congruently, I found that after transferring OT-I T cells into mice bearing OVA+ tumours, proliferation of OT-I T cells in the TdLN was increased post VSV∆M51 treatment. Together, these data suggest that VSV∆M51 infection of non-cancer cells enhances antitumour immunity by increasing antigen presentation and T cell activation in the TdLN. Finally, I asked how cancer cell infections, when present, contribute to antitumour immunity. To do this, I engineered cell lines that were hypersensitive to infection. In the absence of CD8+ T cells, VSV∆M51 infection within the tumour led to transient tumour regression, suggesting that these infections may cause oncolysis and debulking of the tumour. However, durable cures required CD8+ T cells. Further, the presence of an infectable tumour increased regression of a contralateral infection-resistant tumour, demonstrating that infection of cancer cells induces antitumour activity that can act at an abscopal site. Altogether, these data suggest that VSV∆M51 infection of both cancer and non-cancer cells contributes to antitumour immunity.
Lagrangian theory of structure formation in relativistic cosmology I: Lagrangian framework and definition of a nonperturbative approximation
Creators: name: Buchert, Thomas
name: Ostermann, Matthias
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this first paper we present a Lagrangian framework for the description of structure formation in general relativity, restricting attention to irrotational dust matter. As an application we present a self-contained derivation of a general-relativistic analogue of Zel'dovich's approximation for the description of structure formation in cosmology, and compare it with previous suggestions in the literature. This approximation is then investigated: paraphrasing the derivation in the Newtonian framework we provide general-relativistic analogues of the basic system of equations for a single dynamical field variable and recall the first-order perturbation solution of these equations. We then define a general-relativistic analogue of Zel'dovich's approximation and investigate its implications by functionally evaluating relevant variables, and we address the singularity problem. We so obtain a possibly powerful model that, although constructed through extrapolation of a perturbative solution, can be used to put into practice nonperturbatively, e.g. problems of structure formation, backreaction problems, nonlinear properties of gravitational radiation, and light-propagation in realistic inhomogeneous universe models. With this model we also provide the key-building blocks for initializing a fully relativistic numerical simulation.
description: 21 pages, content matches published version in PRD, discussion on singularities added, some formulas added, some rewritten and some corrected
title: Chest x-ray: Incidentaloma
Creators: name: Musa, Eiman
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Education and training
subject: Computer Applications-Detection, diagnosis
subject: Digital radiography
subject: Thorax

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Definition of incidentaloma. Provide relevant and irrelevant incidental finding cases of chest x-rays. Define the impact of indicentaloma on patient management and quality of life. Value of detailed chest x-ray...
Patriots for Empire: Unionism, Imperialism, and Scottish Colonial Administrators in the British Atlantic, 1698-1776
Creators: name: Bates, Zachary Adam
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: British Empire
subject: Colonial America
subject: Scotland
subject: Political Thought
subject: Intellectual History
subject: History--European
subject: History--United States

description: This study expands on understandings of the first British Empire by integrating several Scottish colonial administrators who served in Britain’s North American colonies into its intellectual and political history. It argues that these officials manifested, modified, and maintained a Scoto-British view of the British Empire that developed as a result of the Glorious Revolution in 1688 – which established Britain as a polity ruled by Parliamentary sovereignty – and the Act of Union in 1707 – which forged England and Scotland into a united kingdom. Their intent was to extend their understanding of the revolution and union settlement throughout the British Atlantic empire, and they took great interest in extending Britain’s North American colonial possessions westward and conquering islands in the Caribbean. However, they encountered a colonial understanding of these same events that empowered assemblies and colonial institutions to challenge royal authority, and they expressed concern that the colonies were becoming more republican and would potentially become independent. By the 1720s, many of these officials began to contribute tracts and advice to the Board of Trade, often recommending stricter oversight of the colonies and reforms in their governance, such as direct taxation or Parliamentary intervention; and by the 1730s, they also began to construct a British history that celebrated a progressive vision of Britain’s past that focused on the expansion of liberty, the mixing of different races (Britons, Saxons, Danes, Romans, and others), Britain’s overseas possessions, and continued westward expansion. The Scoto-British view of the empire became increasingly untenable in the 1750s and 1760s due to colonial opposition, and it eventually dissolved with the dismemberment of much of Britain’s North American colonies. Yet, the Scoto-British vision of the empire – based on unionism and imperialism – lingered in the vision of Alexander Hamilton and in the imaginations of several nineteenth-century adherents of Manifest Destiny and in the idea of America as a melting pot. This study fills a gap in the study of the British Empire by reintegrating this view, and it suggests that many of the concepts normally attributed to American exceptionalism had their origins in a larger, British history.
Organization and evolution of synthetic idiotypic networks
Creators: name: Agliari, Elena
name: Asti, Lorenzo
name: Barra, Adriano
name: Ferrucci, Luca
Publisher: name: arXiv
Year: 2011
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We introduce a class of weighted graphs whose properties are meant to mimic the topological features of idiotypic networks, namely the interaction networks involving the B-core of the immune system. Each node is endowed with a bit-string representing the idiotypic specificity of the corresponding B cell and a proper distance between any couple of bit-strings provides the coupling strength between the two nodes. We show that a biased distribution of the entries in bit-strings can yield fringes in the (weighted) degree distribution, small-worlds features, and scaling laws, in agreement with experimental findings. We also investigate the role of ageing, thought of as a progressive increase in the degree of bias in bit-strings, and we show that it can possibly induce mild percolation phenomena, which are investigated too.
description: 13 pages
title: Uncommon and Rare Presentations of Tuberculosis from Head to Toe: An imaging overview
Creators: name: gulati, shrea
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Infection
subject: Education
subject: Diagnostic procedure
subject: CT
subject: Thorax
subject: Head and neck
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim is to illustrate the various uncommon and atypical presentations and complications of tuberculosis from head to...
title: Ethical considerations for artificial intelligence implementation in radiology
Creators: name: Akinci D'Antonoli, Tugba
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Education and training
subject: Ethics
subject: PET-CT
subject: MR
subject: CT
subject: Artificial Intelligence

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: By the end of this educational exhibit, the readers will able to: Discuss the opportunities and challenges of artificial intelligence (AI) Describe the pillars of biomedical ethics and how they might be affected by AI Outline the present regulations...
Athletes’ Intrateam Social Identities and Perceptions of Performance, Group Cohesion, and Group Membership in Female Rugby Teams
Creators: name: Coffey, Monique
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Social identity
subject: Clique
subject: Subgroup
subject: Intragroup relationships
subject: Sport psychology
subject: Recreation
subject: Psychology--Social

description: Social identities (i.e., social group membership) have an impact on individual and team variables within sports teams. Although the benefits of strong perceptions of group membership with one’s team have shown to have benefits for athletes, social identities within sports teams have received much less attention. At the university and elite male sport level, subgroups and cliques within sports teams have been demonstrated to impact interpersonal processes within the team as well as the group environment and team performance. Nevertheless, the presence of these subgroups has not yet been examined at other levels of competition. This gap must be addressed for coaches and sports practitioners to better understand how to create the most positive and successful sports team environments. Informed by the social identity approach, this study aimed to examine how female provincial rugby players use self-categorization and social comparison to form social identities with and within their sports teams. Through purposive sampling, 27 female rugby players were selected from three senior women’s provincial teams to each participate in a one-time semi-structured interview. The results of this study revealed that each team had a unique identity reinforced by the behaviours of team members and teams’ position within the league. Players further discussed the subgroups within their teams and their impact on performance and group cohesion within the team. They described the nature of cliques as negative revealing the negative connotations associated with the word. Based on the results of this study, to reduce the presence of negative subgroups within sports teams, it is recommended that interactions are created between players, especially between those where faultlines, traits which can act to separate a subgroup from another, exist. Furthermore, awareness about the impact of subgroups within teams should be promoted so that players understand the effect of their social identities on the team environment and teammates.
Additional file 2: of Exosomal TRIM3 is a novel marker and therapy target for gastric cancer
Creators: name: Fu, Hailong
name: Yang, Huan
name: Zhang, Xu
name: Wang, Bo
name: Mao, Jiahui
name: Li, Xia
name: Wang, Mei
name: Zhang, Bin
name: Sun, Zixuan
name: Qian, Hui
name: Xu, Wenrong
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Table S2. Primer sequences and amplified fragment products. (DOCX 19 kb)
title: Фейки и «Covid-19»
Creators: name: Мариева, Е. А.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: Фейковая информация распространяется с огромной скоростью. Фейки приводят к панике, неверным действиям множества людей и непоправимым последствиям. Они подрывают доверие людей к источникам правдивой информации в стране и мире. Фейки во время пандемии коронавирусной инфекции сыграли на страхах людей. Во время паники стало гораздо сложнее анализировать полученную информацию и разбираться в ее достоверности. Фейков стало еще больше. В работе рассмотрено понятие фейка, приведены критерии, по которым можно определить, какая информация ложная или правдивая. Подчеркивается важность медиаобразования широкой аудитории.
Secondary Batteries Using a Zinc Negative Electrode
Creators: name: ShakeriHosseinabad, Fatemeh
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Alkaline air cathode
subject: Degradation
subject: Durability
subject: Hydrophobicity
subject: Thickness of active layer
subject: Zinc-iodide
subject: Zinc deposition
subject: Flow field design
subject: Flow-by-through
subject: Battery performance
subject: X-ray computed tomography
subject: Electrode materials
subject: Atomic force microscopy
subject: Engineering

description: Redox flow batteries are considered the most viable option for energy storage among various electrochemical technologies used for electrochemical energy storage. The use of aqueous zinc-based flow batteries offers numerous advantages, such as being environmentally friendly, and constructed from low-cost materials that are abundant and inherently safe. These batteries also have the potential for high theoretical energy density. Alkaline fuel cells / zinc-air batteries face a major hurdle in commercialization due to the degradation of the cathode, which limits their cycle life. In this study, to investigate the durability and degradation of an alkaline air cathode, a novel combination of in-situ and post-mortem analyses was employed. This included modifying the thickness and ratio of carbon/binder in the active layer, as well as monitoring the electrode potential and electrochemical impedance spectroscopy via in-situ analysis. The increased potential loss was found to be caused by the flooding of electrolyte within the primary macro structure of the active layer, leading to an increased mass transfer resistance for oxygen transport. The capability to achieve high power density and prolonged cycle life in zinc-based batteries is hindered by the formation of dendrites on the anode. To address this issue, a new cell design featuring a narrow gap between the electrode and membrane was implemented in a zinc-iodide flow battery. In this novel design, a portion of the electrolyte flows over the electrode surface, and a fraction of the flow passes through the porous felt electrode in the direction of current flow. The power density achieved with the novel flow mode ranks among the highest reported for the zinc-iodide battery. In order to attain high power density and energy density at high current densities, the study employed an electrocatalyst on the positive electrode of the zinc-iodide flow battery, while a perforated copper foil with excellent electrical conductivity was utilized on the negative side. In-situ and ex-situ characterization techniques, including atomic force microscopy coupled with optical microscopy and x-ray diffraction, were employed to elucidate the relationship between the morphology of zinc deposition on the perforated copper foil and battery performance under two different flow field conditions.