cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Die "Rudimenta musices" von Wolfgang Michael Mylius : eine bedeutende deutsche Quelle zur Gesangspraxis im 17. Jahrhundert
Creators: name: Bassani Grampp, Florian
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Christoph Bernhards Gesangslehrwerk 'Von der Singe-Kunst oder Manier' gehört heute zu den zentralen Quellenwerken für den gesanglichen Vortrag barocker Musik. Bei aller Anschaulichkeit der Darstellung bleiben für den heutigen Leser gleichwohl zahlreiche Fragen, insbesondere zum Manierengebrauch, unbeantwortet. Ein Schüler Bernhards erkannte diese Schwachpunkte bereits: Der Thüringer Wolfgang Michael Mylius, der in den Jahren 1661/1662 den Unterricht Bernhards genossen hatte, verfasste 1685, auf der Darstellung seines Lehrers aufbauend, die Rudimenta musices, eine 'kurtze und Grund-richtige Anweisung zur Singe-Kunst'. Die besondere Bedeutung dieses Traktates liegt in einer entscheidenden Neuerung bei der Vermittlung der Lehrinhalte: In einer Serie von Soloarien werden nun Ort und Art der anzubringenden Manieren explizit im Notentext vermerkt. Auf diese Weise erhält der Leser kostbare Direktiven über den Einsatz der Manieren im Dienst des künstlerischen Vortrags. Die kritische Neuausgabe der den Gesangsvortrag betreffenden Abschnitte der Rudimenta musices steht gleichsam in einer Reihe mit der von Joseph Müller-Blattau in den 1920er Jahren realisierten Edition von Bernhards Traktat. In der vorliegenden Arbeit werden, zusätzlich zum mylius'schen Lehrstoff, die Arien mit Manieren in einer vollständigen Umschrift vorgelegt, die als reichhaltiges und in der didaktischen Literatur beispielloses Anschauungsmaterial dem Leser ein erstaunlich detailliertes Bild von den Gesangsmanieren des 17. Jahrhunderts bietet. (Autor) Quelle: Bibliographie des Musikschrifttums online
description: Schütz-Jahrbuch, Bd. 30 (2008)
Wingspread Article, Oldest Courtroom, Randolph Air Force Base, Texas
Creators: name: Walter, Chelsea
Publisher: name: Wingspread
Year: 1995
Subjects: subject: Universal City
valueUri: https://core.tdar.org/browse/geographic-keyword/42082/universal-city
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research

description: An article from Wingspread's May 26, 1995 publication. The clipping shows Captains Chris Aluotto and Ron Ratton standing next to a plaque designating Randolph Air Force Base's courtroom as the Air Force's oldest courtroom still in use. The article goes on to give a brief historical overview of the courtroom and the award given.
Dirac Coupled Channel Analyses of the 2$^-$ Gamma Vibrational band excitation in $^{20}$Ne
Creators: name: Shim, Sugie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Dirac coupled channel analyses are performed using optical potential model for the high-lying excited states that belong to the 2$^-$ gamma vibrational band at the 800 MeV unpolarized proton inelastic scatterings from $^{20}$Ne. The first order vibrational collective models are used to obtain the transition optical potentials to describe the high-lying excited vibrational collective states and Lorentz-covariant scalar and time-like vector potentials are used as direct optical potentials. The complicated Dirac coupled channel equations are solved phenomenologically to reproduce the differential cross sections data by varying the optical potential and deformation parameters using minimum chi-square method. It is found that relativistic Dirac coupled channel calculation could describe the excited states of the 2$^-$ gamma vibrational band in $^{20}$Ne much better than the nonrelativistic coupled channel calculation, especially for the 2$^-$ and 3$^-$ states of the band. It is shown that the multistep excitation process via channel coupling with the $3^-$ state is essential to describe the $2^-$ state excitation and pure direct transition from the ground state is dominant for the 3$^-$ state excitation of the 2$^-$ gamma vibrational band in $^{20}$Ne.
description: 5 figures, 10 pages
Thermal and residual stress modeling of functionally graded deposits using the PTAAM
Creators: Bonias, Geoffrey
Publisher: name: University of Alberta Library
Year: 2022

High maintenance costs due to significant abrasive wear of components is experienced in the energy and mining sectors despite the current use of tough and hard coatings. During the coating process significant detrimental residual stresses may build up and result in premature failure of a component. These stresses can be reduced by adopting functionally graded structures of the composite. The main goal of the present study is to design an ideal additively manufactured path and print functionally graded geometries using plasma transferred arc (PTA) with WC-Ni alloy composite. To develop a comprehensive analysis of the functionally graded deposit, the thermal history of the WC and Ni alloy powders must first be simulated as they travel through the plasma and deposit on the substrate. Predictions of particle trajectories in the plasma are compared to experimentally tracked powder particles to validate the model. The power transferred from the arc to the anode is divided into an electronic, a convective and a radiative contribution and is then estimated. The dependency of the thermal history of the WC and Ni powder particles and of the heat input from the arc to the anode on the PTA operating parameters is discussed quantitatively. Inferences from this preliminary work are then used as input data to simulate the additive manufacturing of functionally graded materials at the macro scale level. The thermal history followed by the thermal stress history of the process is predicted, and finally the residual stress distribution is obtained for a wall-shaped printed part. Simulations are performed on Abaqus for different material gradients under the same operating conditions. The residual stress profiles of each material gradient are compared to each other and to a wall without gradient. Conclusions are drawn as to the material gradation that is most susceptible to enhance the coating wear resistance from a residual stress perspective. Future work could focus on validating the thermal and residual stress model and establishing the wear characteristics of the graded deposits. Using the model, strategies could be established to optimize the temperature history of the graded coating during its printing to further reduce tensile residual stresses and reduce WC settling in the liquid bead to improve homogeneity.
Breslau als Zentrum der Musikkultur Schlesiens im 17. Jahrhundert
Creators: name: Pospiech, Remigiusz
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Im 17. Jahrhundert wirkte Breslau als Zentrum der Musikkultur Schlesiens. Dieser Artikel gibt Einblick in die Musikkultur Breslaus zu dieser Zeit und trennt zwischen dem Musikleben der evangelischen Gemeinden und katholischen Kirchen und Klöstern.
description: Schütz-Jahrbuch, Bd. 32 (2010)
Search for the lepton flavor violating decay $Z \rightarrow e μ$ in pp collisions at $\sqrt{s}$ = 8 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ATLAS detector at the Large Hadron Collider is used to search for the lepton flavor violating process $Z \rightarrow e μ$ in pp collisions using 20.3 $fb^{-1}$ of data collected at $\sqrt{s}$ = 8 TeV. An enhancement in the $e μ$ invariant mass spectrum is searched for at the Z boson mass. The number of Z bosons produced in the data sample is estimated using events of similar topology, $Z \rightarrow ee$ and $μμ$, significantly reducing the systematic uncertainty in the measurement. There is no evidence of an enhancement at the Z boson mass, resulting in an upper limit on the branching fraction, $B(Z \rightarrow e μ)$ < 7.5 x 10$^{-7}$ at the 95% confidence level.
description: 6 pages plus author list + cover pages (19 pages total), 3 figures, 1 table, submitted to Phys. Rev. D, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2013-02/
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Creators: name: Valdar, William
name: Sullivan, Patrick F
name: Kim, Yunjung
name: Pardo-Manuel de Villena, Fernando
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Complex human traits are influenced by variation in regulatory DNA through mechanisms that are not fully understood. Since regulatory elements are conserved between humans and mice, a thorough annotation of cis regulatory variants in mice could aid in this process. Here we provide a detailed portrait of mouse gene expression across multiple tissues in a three-way diallel. Greater than 80% of mouse genes have cis regulatory variation. These effects influence complex traits and usually extend to the human ortholog. Further, we estimate that at least one in every thousand SNPs creates a cis regulatory effect. We also observe two types of parent-of-origin effects, including classical imprinting and a novel, global allelic imbalance in favor of the paternal allele. We conclude that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals.
The 2002 Australasian Journal of Podiatric Medicine members' survey - a summary of results
Creators: name: Raspovic, Anita
Publisher: name: La Trobe
Year: 2023

description: The principle aims of the survey were to evaluate the AJPM in regards to the following: current levels of satisfaction; perceptions of whether professional needs are being met; additional journal requirements; and preferences regarding the future provision of a professional journal.
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Creators: name: Altshuler, David
name: Morris, Andrew P
name: Gaulton, Kyle J
name: McCarthy, Mark I
name: Boehnke, Michael
name: Teslovich, Tanya M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We performed fine-mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in/near KCNQ1. “Credible sets” of variants most likely to drive each distinct signal mapped predominantly to non-coding sequence, implying that T2D association is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine-mapping implicated rs10830963 as driving T2D association. We confirmed that this T2D-risk allele increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D-risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
Wraparound School Supports: Exploring Students’ Experiences of Meaningful Relationships with Caring Adults
Creators: Schultz, Jessica Lynne
Publisher: name: University of Alberta Library
Year: 2022

Relationships are not only important to healthy youth development but may be the key ingredient which make intervention programs with youth successful. This study used data from evaluation of a wraparound school initiative called All in For Youth which has, among others, an aim of building and maintaining meaningful relationships between students and caring adults. This study explored students’ experiences of how caring adults built positive relationships with them. Results showed three themes that illustrate how adults built these relationships. The first theme reveals that adults build relationships through their interactions with youth. Three subthemes highlight interactions that provide support, promote growth, and involve a social component. The second theme identifies caring skills adults demonstrated that nurtured close relationships. The three associated subthemes show adults were dependable, encouraging, and emotionally intelligent. The third theme discusses how adults build relationships through fostering supportive environments. Three subthemes describe that adults enabled connections, created safe spaces, and utilized team communication. In addition to the three core themes that illustrate how adults build relationships, a fourth theme discussed the evolving nature of student-adult relationships, where it was found that some relationships progressed after students’ high school graduation. This study aligns with current research on developmental relationships and highlights the potential that wraparound school support initiatives, like the AIFY program, have for continuing research on these important relationships between youth and non-family adults.
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Creators: name: Rahman, Nazneen
name: Lush, Michael J
name: Bojesen, Stig E
name: Wang, Qin
name: Nordestgaard, Børge G
name: Maranian, Mel J
name: Turnbull, Clare
name: Bolla, Manjeet K
name: Shah, Mitul
name: Brand, Judith S
name: Darabi, Hatef
name: Lindstrom, Sara
name: Eilber, Ursula
name: Perkins, Barbara J
name: Nevanlinna, Heli
name: Beesley, Jonathan
name: Dennis, Joe
name: Nielsen, Sune F
name: Behrens, Sabine
name: Michailidou, Kyriaki
name: Flesch-Janys, Dieter
name: dos-Santos-Silva, Isabel
name: Czene, Kamila
name: Flyger, Henrik
name: Muranen, Taru A
name: Canisius, Sander
name: Chang-Claude, Jenny
name: Fletcher, Olivia
name: Eriksson, Mikael
name: Gibson, Lorna
name: Peto, Julian
name: Rudolph, Anja
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Genome wide association studies (GWAS) and large scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS comprising of 15,748 breast cancer cases and 18,084 controls, and 46,785 cases and 42,892 controls from 41 studies genotyped on a 200K custom array (iCOGS). Analyses were restricted to women of European ancestry. Genotypes for more than 11M SNPs were generated by imputation using the 1000 Genomes Project reference panel. We identified 15 novel loci associated with breast cancer at P<5×10−8. Combining association analysis with ChIP-Seq data in mammary cell lines and ChIA-PET chromatin interaction data in ENCODE, we identified likely target genes in two regions: SETBP1 on 18q12.3 and RNF115 and PDZK1 on 1q21.1. One association appears to be driven by an amino-acid substitution in EXO1.
MPEC 2023-R38 : 2023 RR
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 RR

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Response from Sharon Fleming to John Brenneman, Landscape Master Plan, Fort Sam Houston, Texas
Creators: name: Fleming, Sharon E.
name: Graves, Stanley O.
Publisher: name: Texas Historical Commission
Year: 1995
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Texas Historical Commission has received and reviewed from Fort Sam Houston a copy of the "Landscape Master Plan." The Plan is a model planning project which combines historic preservation with other important concerns such as water conservation. This letter details comments and concerns of the Commission concerning the project. Copied to this correspondence is Mike Hilger, Historical Architect, Fort Sam Houston.
Instabilities in large economies: aggregate volatility without idiosyncratic shocks
Creators: name: Bonart, Julius
name: Bouchaud, Jean-Philippe
name: Landier, Augustin
name: Thesmar, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Economics (econ.GN)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: We study a dynamical model of interconnected firms which allows for certain market imperfections and frictions, restricted here to be myopic price forecasts and slow adjustment of production. Whereas the standard rational equilibrium is still formally a stationary solution of the dynamics, we show that this equilibrium becomes linearly unstable in a whole region of parameter space. When agents attempt to reach the optimal production target too quickly, coordination breaks down and the dynamics becomes chaotic. In the unstable, "turbulent" phase, the aggregate volatility of the total output remains substantial even when the amplitude of idiosyncratic shocks goes to zero or when the size of the economy becomes large. In other words, crises become endogenous. This suggests an interesting resolution of the "small shocks, large business cycles" puzzle.
Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Creators: name: Day, Felix R
name: McArdle, Patrick F
name: Johnson, Andrew D
name: Lunetta, Kathryn L
name: Yao, Jie
name: Keller, Margaux F
name: Huffman, Jennifer E
name: Teumer, Alexander
name: Thompson, Deborah J
name: Finucane, Hilary K
name: Rose, Lynda M
name: Nutile, Teresa
name: Franke, Lude L
name: Vuckovic, Dragana
name: He, Chunyan
name: Bulik-Sullivan, Brendan
name: Porcu, Eleonora
name: Franceschini, Nora
name: Zhao, Wei
name: Chasman, Daniel I
name: Pervjakova, Natalia
name: Altmaier, Elisabeth
name: Stolk, Lisette
name: Elks, Cathy E
name: Sulem, Patrick
name: Ruth, Katherine S
name: Robino, Antonietta
name: Smith, Jennifer A
name: Esko, Tõnu
name: Brody, Jennifer A
name: Schick, Ursula M
name: Traglia, Michela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.
Bucking the Trend: Large-Scale Cost-Focused Active Learning for Statistical Machine Translation
Creators: name: Bloodgood, Michael
name: Callison-Burch, Chris
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: I.2.7; I.2.6; I.5.1; I.5.4

description: We explore how to improve machine translation systems by adding more translation data in situations where we already have substantial resources. The main challenge is how to buck the trend of diminishing returns that is commonly encountered. We present an active learning-style data solicitation algorithm to meet this challenge. We test it, gathering annotations via Amazon Mechanical Turk, and find that we get an order of magnitude increase in performance rates of improvement.
description: 11 pages, 14 figures; appeared in Proceedings of the 48th Annual Meeting of the Association for Computational Linguistics, July 2010
Intermediate Coupling Model of the Cuprates
Creators: name: Das, Tanmoy
name: Markiewicz, R. S.
name: Bansil, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We review the intermediate coupling model for treating electronic correlations in the cuprates. Spectral signatures of the intermediate coupling scenario are identified and used to adduce that the cuprates fall in the intermediate rather than the weak or the strong coupling limits. A robust, `beyond LDA' framework for obtaining wide-ranging properties of the cuprates via a GW-approximation based self-consistent self-energy correction for incorporating correlation effects is delineated. In this way, doping and temperature dependent spectra, from the undoped insulator to the overdoped metal, in the normal as well as the superconducting state, with features of both weak and strong coupling can be modeled in a material-specific manner with very few parameters. Efficacy of the model is shown by considering available spectroscopic data on electron and hole doped cuprates from angle-resolved photoemission (ARPES), scanning tunneling microscopy/spectroscopy (STM/STS), neutron scattering, inelastic light scattering, optical and other experiments. Generalizations to treat systems with multiple correlated bands such as the heavy-fermions, the ruthenates, and the actinides are discussed.
description: Review to be published in Advances in Physics. 120 pages, 58 figures
Ein Stammbuchblatt von Heinrich Schütz?
Creators: name: Pegah, Rashid-S.
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag widmet sich einem Stammbuch mit einem Eintrag eines Heinrich Schütz, das sich als fotographische Reproduktion in der Handschriftenabteilung der Universitätsbibliothek Kassel befindet. Es soll sich um ein Stammbuch von Schütz‘ Bruder Georg handeln, worauf vor allem Tuschezeichnung mit musikalischen Motiven hinweisen.
description: Schütz-Jahrbuch, Bd. 32 (2010)
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Seguendo gli itinerari che percorre Hugo von Hofmannsthal nel corso della sua vita, il saggio si propone di analizzare la sua opera, nello specifico i racconti in prosa, da una prospettiva geo-critica. L’esperienza del viaggio, e in particolare il luogo visitato, sono il fondamentale punto di partenza per un percorso di maturazione artistica e personale. Soprattutto nell’opera tarda, i resoconti dei viaggi in Grecia, Sicilia e Marocco mostrano lo sviluppo di una geopoetica, che delinea una profonda presa di consapevolezza linguistico-letteraria.
description: The aim of this essay is to analyze Hugo von Hofmannsthal’s work from a geo-critical perspective, by following the routes of travel throughout his life. The travel experiences, and in particular the places he visited, are the fundamental starting point for a path of artistic and personal maturation. Especially in the late work, the reports of his travels to Greece, Sicily and Morocco outline the development of a geopoetics, which shows a heightened awareness of his linguistic and literary value.
"Musica noster Amor" : Musikereinträge im Stammbuch von Sethus Calvisius d. J.
Creators: name: Maul, Michael
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag untersucht Musikereinträge im Stammbuch von Sethus Calvisius (1606-1663), das sich im Handschriftenbestand der Forschungs- und Universitätsbibliothek Gotha befindet.
description: Schütz-Jahrbuch, Bd. 32 (2010)
Base Engineer Work Request, Building 661 Room 102, Randolph Air Force Base, Texas
Creators: name: , Stanley
name: Loser, Gregory A.
Year: 1993
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Room 102
valueUri: https://core.tdar.org/browse/other-keyword/158781/room-102
subject: Building 661
valueUri: https://core.tdar.org/browse/other-keyword/146442/building-661
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Work request form for Building 661, Randolph Air Force Base, Texas. The proposed undertaking is focused on Room 102 and includes the installation of infrared motion detectors, an alarm system panel and keypad, seal off and/or secure entrance doors with deadbolt, balanced magnetic sensor, automatic door closer, deadbolt, and cypher lock on entrance door.
Population genetic differentiation of height and body mass index across Europe
Creators: name: Visscher, Peter M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Across-nation differences in the mean of complex traits such as obesity and stature are common1–8, but the reasons for these differences are not known. Here, we find evidence that many independent loci of small effect combine to create population genetic differences in height and body mass index (BMI) in a sample of 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased estimates of effect sizes from 17,500 sib pairs, we estimate that 24% (95% CI: 9%, 41%) and 8% (95% CI: 4%, 16%) of the captured additive genetic variance for height and BMI across Europe are attributed to among-population genetic differences. Population genetic divergence differed significantly from that expected under a null model (P <3.94e−08 for height and P<5.95e−04 for BMI), and we find an among-population genetic correlation for tall and slender nations (r = −0.80 (95% CI: −0.95, −0.60), contrasting no genetic correlation between height and BMI within populations (r = −0.016, 95% CI: −0.041, 0.001), consistent with selection on height genes that also act to reduce BMI. Observations of mean height across nations correlated with the predicted genetic means for height (r = 0.51, P<0.001), so that a proportion of observed differences in height within Europe reflect genetic factors. In contrast, observed mean BMI did not correlate with the genetic estimates (P<0.58), implying that genetic differentiation in BMI is masked by environmental differences across Europe.
The genomic landscape of juvenile myelomonocytic leukemia
Creators: name: Mahoney, Donald H
name: Yu, Ariel
name: Stewart, Chip
name: Costello, Joseph F
name: Stine, Kimo C
name: Stieglitz, Elliot
name: Cooper, Todd
name: Liu, Y Lucy
name: Olshen, Adam B
name: Gerbing, Robert B
name: Goyal, Rakesh K
name: Hugge, Christopher
name: Beckman, Kyle
name: Brown, Patrick A
name: Toretsky, Jeffrey A
name: Briones, Michael
name: Ma, Jing
name: Nemecek, Eneida R
name: Roehrs, Philip A
name: Abusin, Ghada
name: Schore, Reuven J
name: Hitzler, Johann
name: Li, Yongjin
name: Hayashi, Robert J
name: Monteleone, Philip
name: Carcamo, Benjamin
name: Emanuel, Peter D
name: Messinger, Yoav H
name: Archambeault, Sophie L
name: Takemoto, Clifford M
name: Fluchel, Mark N
name: Dahl, Gary V
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 and CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and therefore be candidates for experimental therapies. In addition, there have been few other molecular pathways identified aside from the Ras/MAPK pathway to serve as the basis for such novel therapeutic strategies. We therefore sought to genomically characterize serial samples from patients at diagnosis through relapse and transformation to acute myeloid leukemia in order to expand our knowledge of the mutational spectrum in JMML. We identified recurrent mutations in genes involved in signal transduction, gene splicing, the polycomb repressive complex 2 (PRC2) and transcription. Importantly, the number of somatic alterations present at diagnosis appears to be the major determinant of outcome.
Targeting Apoptosis and Necroptosis Inhibition to Improve Islet Graft Function
Creators: Aggarwal, Saloni
Publisher: name: University of Alberta Library
Year: 2022

Islet cell transplantation is an effective method to treat type 1 diabetes mellitus, however, significant barriers currently exist preventing its implementation as the gold standard therapy. Of note, cell death in the acute post-transplant period accounts for loss of up to 80% of newly transplanted islets. Cell death can be mediated in multiple different ways, and the two primary forms of cell death are apoptosis and necrosis. Significant efforts have been applied in preventing apoptosis following islet transplantation, however, concurrent inhibition of both pathways simultaneously is a relatively new approach. In this thesis, we investigated the effect of apoptosis and regulated necrosis inhibition on β-cell survival and function, both in vivo and in vitro. MIN6 cells, derived from an immortalized mouse insulinoma, were cultured with and without apoptosis (ZVAD-FMK) and regulated necrosis inhibitors (Necrostatin 1, Necrostatin 1s) for 24-72 hours, and under basal and stressed conditions. Cell vitality, glucose stimulated insulin secretion, and oxygen consumption rates were measured and analyzed. This revealed statistically significant differences between treated and untreated cells, suggesting the therapeutic potential of treating islets with apoptosis and regulated necrosis inhibitors prior to islet transplantation.

Next, human islets were treated for 24h with apoptosis and regulated necrosis inhibitors, and marginal mass transplantation of these islets under the kidney capsule of diabetic mice was performed. Mice were followed for 60 days, and improved reversal of diabetes and maintenance of glycemic control was observed in mice treated with the inhibitors in combination and alone. This indicates that pre-treatment of islets with apoptosis and regulated necrosis inhibitors prior to transplantation may reduce cell death following transplantation, and potentially improve islet engraftment. This is of great clinical relevance, as targeting regulated cell death effectively may in the future lead to improved single donor success rates, reduced islet mass required in each transplant, and long-term insulin independence following the procedure.
The Rhetoric of Interruption in Giovanni Felice Sances's "Motetti a voce sola" (1638)
Creators: name: Weaver, Andrew H.
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Andrew Weaver analysiert die Motette „Solvatur lingua mea“ für Solotenor (1638) von Giovanni Felice Sances (ca. 1600-1679) und geht dabei besonders auf die rhetorische Figur der Unterbrechung ein. Im Appendix ist die Motette selbst angefügt.
description: Schütz-Jahrbuch, Bd. 32 (2010)
The effects of salinity on aquatic plant germination and zooplankton hatching from two wetland sediments
Creators: name: Nielsen, Daryl L
name: Brock, Margaret A
name: Crossle, Katharine
name: Harris, Ken
name: Healey, Michael
name: Jarosinski, Irene
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

1. The effect of increasing salinity on the emergence of zooplankton eggs and the germination of aquatic plant seeds from the sediment of two wetlands was examined. Salinity was found to cause reductions in species richness and abundance of aquatic plants and zooplankton at salinities between 1000 and 5000 mg L−1. Aquatic plants also had an associated decrease in above ground biomass.2. Individual taxa showed different responses to salinity, and four response patterns were identified: (i) increased number of organisms emerging at 1000 mg L−1; (ii) decreased number of organisms emerging above 1000 mg L−1; (iii) decreased number of organisms emerging between 300 and 1000 mg L−1; (iv) no difference in number of organisms emerging across the range of salinities. Response patterns (iii) and (iv) were common to both plants and zooplankton, whereas response patterns (i) and (ii) were only identified for zooplankton.3. Results indicate that there is potential for the increasing salinity in Australian rivers and wetlands to decrease the species richness of aquatic communities resulting in loss of wetland biodiversity.
Symbolische Kommunikation und musikalische Repräsentation: der Friede von Nijmegen (1679) im Spiegel zeitgenössischer Kompositionen
Creators: name: Rathey, Markus
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Eine strikte Trennung zwischen geistlicher und weltlicher Sphäre ist in der vormodernen Gesellschaft kaum möglich. Dieser Artikel beleuchtet unter anderem die Verschränkung dieser beiden Sphären oder dieser beiden „Reiche“ in Heinrich Schütz‘ doppelchöriger Motette Da pacem, Domine (1627, SWV 465), vor allem in derer Mehrtextigkeit. Auch andere Kompositionen werden in ihrer intertextuellen Verflechtung zwischen weltlicher und geistlicher Ebene untersucht.
description: Schütz-Jahrbuch, Bd. 32 (2010)
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Creators: name: Justesen, Johanne M
name: Verweij, Niek
name: Stram, Daniel O
name: Asselbergs, Folkert W
name: Chambers, John C
name: Ueshima, Hirotsugu
name: Elliott, Paul
name: Deloukas, Panos
name: Chong, Yap-Seng
name: Kooner, Jaspal S
name: Dorajoo, Rajkumar
name: Franke, Lude
name: Akiyama, Koichi
name: Liewald, David C M
name: Tai, E Shyong
name: Campanella, Gianluca
name: van der Harst, Pim
name: Abbott, James
name: Esko, Tõnu
name: Lee, Jong-Young
name: Wijmenga, Cisca
name: Takeuchi, Fumihiko
name: Ohnaka, Keizo
name: Spiering, Wilko
name: Ye, Xingwang
name: Kleber, Marcus E
name: Linneberg, Allan
name: Nakatochi, Masahiro
name: Soong, Richie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
Towards Efficient Co-Simulation of Cyber-Physical Systems
Creators: Aziz, Talha I
Publisher: name: University of Alberta Library
Year: 2022

A cyber-physical system (CPS) is composed of interacting physical and computational components. CPS research addresses the combined sensing and actuating to monitor and control a CPS. Simulation techniques are used in advance of costly CPS deployments to provide sufficient understanding of the complex interactions within a CPS, but such simulations involve the simulation across multiple domains. High fidelity simulators for specific domains already exist, but are not built to interact with other simulators. To address this issue we adopt a co-simulation approach. Co-simulation requires a means of interaction and coordination among multiple simulators, guaranteeing that each simulator is informed of changes in the state of the other simulators that could influence its own state, and that events across multiple simulators do not violate causality. We adopt MOSAIK as the co-simulation framework and we illustrate how existing simulators are adapted to interface with the framework. We produce examples of co-simulation scenarios to capture a class of CPS problems, namely, smart-grid applications. The legacy simulators used, and partly modified, to interface with MOSAIK are OpenDSS, a power flow simulator for electrical grids, and ns-3, a data networking simulator. We address the problem of the joint configuration of the simulators using a combined ontology expressing the union of the simulated domains. We evaluate the performance of our co-simulation by simulating large scale smart-grid applications. The results demonstrate that with some additional programming effort, refinements in the handling of events within each individual simulator can improve the overall co-simulation efficiency.
The influence of vertical mixing on the photoinhibition of variable chlorophyll a fluorescence and its inclusion in a model of phytoplankton photosynthesis
Creators: name: Oliver, Roderick L
name: Whittington, John
name: Lorenz, Zygmunt
name: Webster, Ian T
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The maximum effective quantum yield of photosystem II was estimated from measurements of variable chlorophyll a fluorescence [(F'm - F'o)/F'm = F'v/F'm] in samples of phytoplankton collected from various depths in Chaffey Reservoir, Australia. During stratified conditions, F'v/F'm showed depth-dependent decreases as irradiance increased during the morning, and increases asirradiance reduced in the afternoon. Wind-induced mixing disrupted the diel pattern, but even under well-mixed conditions a vertical gradient in F'v/F'm remained. Differences in F'v/F'm values between samples incubated at fixed depths and unconstrained lake samples enabled identification of the phytoplankton mixing depth. Recovery of F'v/F'm was modelled as a function of time and the degree of F'v/F'm inhibition, while damage was considered a function of photon dose. A combined, numerical model was fitted to diel sequences of F'v/F'm to estimate rate constants for damage and repair. Recovery rate constants ranged from r = 0.7 x 10-4 to 9.1 x 10-4 s-1, while damage rate constants ranged from k = 0.03 to 0.22 m2 mol photon-1. A fluorescence-based model of photosynthesis was used to investigate the effects of wind speed, euphotic depth and mixed layer depth on photoinhibition. At different mixing rates, depth-integrated photosynthesis was enhanced by up to 16% under the conditions tested, while increases of 9% occurred between phytoplankton with different measured damage and repair characteristics.
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
Creators: name: Iacobuzio-Donahue, Christine A
name: Hollingsworth, Michael A
name: Yeh, Jen Jen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes capturing precise tumor-specific molecular information difficult. Here, we have overcome this problem by applying blind source separation to a diverse collection of PDAC gene expression microarray data, which includes primary, metastatic, and normal samples. By digitally separating tumor, stroma, and normal gene expression, we have identified and validated two tumor-specific subtypes including a “basal-like” subtype which has worse outcome, and is molecularly similar to basal tumors in bladder and breast cancer. Furthermore, we define “normal” and “activated” stromal subtypes which are independently prognostic. Our results provide new insight into the molecular composition of PDAC which may be used to tailor therapies or provide decision support in a clinical setting where the choice and timing of therapies is critical.
A pair of oscillators interacting with a common heat bath
Creators: name: Ford, G. W.
name: O'Connell, R. F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here the problem considered is that of a pair of oscillators coupled to a common heat bath. Many, if not most, discussions of a single operator coupled to a bath have used the independent oscillator model of the bath. However, that model has no notion of separation, so the question of phenomena when the oscillators are near one another compared with when they are widely separated cannot be addressed. Here the Lamb model of an oscillator attached to a stretched string is generalized to illustrate some of these questions. The coupled Langevin equations for a pair of oscillators attached to the string at different points are derived and their limits for large and small separations obtained. Finally, as an illustration of a different phenomenon, the fluctuation force between a pair of masses attached to the string is calculated, with closed form expressions for the force at small and large separations.
Electric Power Allocation in a Network of Fast Charging Stations
Creators: name: Bayram, I. Safak
name: Michailidis, George
name: Devetsikiotis, Michael
name: Granelli, Fabrizio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: In order to increase the penetration of electric vehicles, a network of fast charging stations that can provide drivers with a certain level of quality of service (QoS) is needed. However, given the strain that such a network can exert on the power grid, and the mobility of loads represented by electric vehicles, operating it efficiently is a challenging problem. In this paper, we examine a network of charging stations equipped with an energy storage device and propose a scheme that allocates power to them from the grid, as well as routes customers. We examine three scenarios, gradually increasing their complexity. In the first one, all stations have identical charging capabilities and energy storage devices, draw constant power from the grid and no routing decisions of customers are considered. It represents the current state of affairs and serves as a baseline for evaluating the performance of the proposed scheme. In the second scenario, power to the stations is allocated in an optimal manner from the grid and in addition a certain percentage of customers can be routed to nearby stations. In the final scenario, optimal allocation of both power from the grid and customers to stations is considered. The three scenarios are evaluated using real traffic traces corresponding to weekday rush hour from a large metropolitan area in the US. The results indicate that the proposed scheme offers substantial improvements of performance compared to the current mode of operation; namely, more customers can be served with the same amount of power, thus enabling the station operators to increase their profitability. Further, the scheme provides guarantees to customers in terms of the probability of being blocked by the closest charging station. Overall, the paper addresses key issues related to the efficient operation of a network of charging stations.
description: Published in IEEE Journal on Selected Areas in Communications July 2013
Response from Claudia Nissley to Donald Peterson, Rehabilitation of Building 902, Randolph Air Force Base, Texas
Creators: name: Nissley, Claudia
Publisher: name: Advisory Council on Historic Preservation
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 902
valueUri: https://core.tdar.org/browse/other-keyword/146467/building-902
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Advisory Council has received Randolph Air Force Base's letter that outlines the measures taken to meet the requirements of Section 110 and 106 for the rehabilitation project at Building 902. This letter is part of correspondence concerning the rehabilitation and replacement of windows and doors at Building 902, Randolph Air Force Base, Texas. Also included are notes and discussion on organization and the process of gaining permission for the undertakings.
Harmonie des Klanglichen und der Erscheinungsform: die Bedeutung der Orgelbauerfamilien Beck und Compenius für die mitteldeutsche Orgelkunst der Zeit vor Heinrich Schütz
Creators: name: Aumüller, Gerhard
name: Hobohm, Wolf
name: Schröder, Dorothea
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag widmet sich den Orgelbauerfamilien Beck und Compenius und ihrer Bedeutung für die mitteldeutsche Orgelkunst der Zeit vor Heinrich Schütz. Zahlreiche Orgelbauten werden aufgezählt.
description: Schütz-Jahrbuch, Bd. 32 (2010)
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Creators: name: Lei, Yu
name: Wen, Haitao
name: Huang, Max Tze-Han
name: Zhang, Lu
name: Gris, Denis
name: Brickey, Willie June
name: Ting, Jenny P-Y
name: Jha, Sushmita
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance; yet, how IL-1β is induced by fatty acid with HFD, and how this alters insulin signaling is unclear. We show that the saturated fatty acid, palmitate, but not unsaturated oleate, induces the activation of NLRP3-PYCARD inflammasome, causing caspase-1, IL-1β, and IL-18 production. This involves mitochondrial reactive oxygen species and the AMP-activated protein kinase and ULK1 autophagy signaling cascade. Inflammasome activation in hematopoietic cells impairs insulin signaling in several target tissues to reduce glucose tolerance and insulin sensitivity. Furthermore, IL-1β affects insulin sensitivity via TNF-independent and dependent pathways. These findings provide insights into the association of inflammation, diet and T2D.