cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 02_1037
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Hirota bilinear equations for Painlevé transcendents
Creators: name: Hone, A. N. W.
name: Zullo, F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We present some observations on the tau-function for the fourth Painlevé equation. By considering a Hirota bilinear equation of order four for this tau-function, we describe the general form of the Taylor expansion around an arbitrary movable zero. The corresponding Taylor series for the tau-functions of the first and second Painlevé equations, as well as that for the Weierstrass sigma function, arise naturally as special cases, by setting certain parameters to zero.
description: This is version n.2, some typos have been fixed (e.g. formula 31), a formula for the coefficients \hat{A}_j in section 4 has been added, the references have been updated
title: ADCO, Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Cart. 198-01 (11 H 1055), 185 folios, f. 0037
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0037, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0037, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
The Constitutional Dimension of European Criminal Law
Creators: name: Mitsilegas, Valsamis
Publisher: name: University of Bologna Law Review
Year: 2019
Subjects: Constitutional Law; European Criminal Law; Supranational Litigation; Taricco Case; European Integration

description: Keynote speech for the Annual Colloquium of the University of Bologna Law Review, February 20th, 2019, Alma Mater Studiorum University of Bologna (Bologna, Italy).
description: University of Bologna Law Review, Vol 4, No 2 (2019)
CPT for PTSD: connections to psychodynamic theory and implications for the APA PTSD clinical practice guideline
Creators: name: Cohen, Donald
Publisher: name: No Publisher Supplied
Year: 2024

description: Cognitive Processing Therapy (“CPT”) is an effective treatment for posttraumatic stress disorder (“PTSD”), as discussed in the American Psychological Association’s Clinical Practice Guideline for the Treatment of PTSD (APA, 2017). Resick & Schnicke (1992, 1993) originally presented cognitive processing therapy as an extension of information processing theories for PTSD and did not explicitly discuss any connections to psychodynamic theory or practice. Nevertheless, as discussed by Resick and Schnicke (1990), the theories that led up to the creation of CPT had connections to analytic theory (i.e., Horowitz, 1976) and practice (i.e., McCann, Sakheim, & Abrahamson, 1988). This dissertation explores how psychodynamic concepts were influential, integrated, or duplicated in the information processing theories that Resick and Schnicke (1992, 1993) discussed in the creation of CPT, as well as in CPT itself. Every information processing theory of PTSD referenced by Schnicke and Resick (1992, 1993) in the creation of CPT had a connection to psychodynamic theory. As information processing theories progressed, the explicit influence of psychodynamic thought was lost in the literature. CPT’s connections to psychodynamic theory range from broader conceptual issues to the inclusion of an unaltered sentence from a psychodynamic article in the original CPT manual (Resick & Schnicke, 1993) that appeared without citations. In a parallel process, when the APA (2017) published their Clinical Practice Guidelines for the Treatment of PTSD, the authors did not explicitly mention psychodynamic theory or practice. The influence of psychodynamic theory on the field of trauma treatment underscores the importance of the open exchange of ideas and psychotherapy integration. The implications of the exclusion of psychodynamic psychotherapy from the clinical practice guidelines are discussed.
Additional file 9: Figure S6. of The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies
Creators: name: Ando, Toshiya
name: Fujiwara, Haruhiko
name: Kojima, Tetsuya
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology

description: The reconstructed exon sequences of al1 mRNA isoforms. Yellow, open reading frame; pink, homeobox. (PDF 108Â kb)
Eu-China Bit and FTA Enhance Labor Cooperation and Protection
Creators: name: Brown, Ronald C.
Publisher: name: University of Bologna Law Review
Year: 2019
Subjects: China; EU-China Free Trade Agreement; International Labor Cooperation EU and China

description: Presentation at the 17th International Conference in Commemoration of Professor Marco Biagi, "The Collective Dimensions of Employment Relations: Organisational and Regulatory Challenges in a World of Work in Transformation", March 18th-19th, 2019, Marco Biagi Foundation - University of Modena and Reggio Emilia (Modena, Italy).
description: University of Bologna Law Review, Vol 4, No 2 (2019)
Fast Low-Rank Kernel Matrix Factorization through Skeletonized Interpolation
Creators: name: Cambier, Léopold
name: Darve, Eric
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: Integral equations are commonly encountered when solving complex physical problems. Their discretization leads to a dense kernel matrix that is block or hierarchically low-rank. This paper proposes a new way to build a low-rank factorization of those low-rank blocks at a nearly optimal cost of $\mathcal{O}(nr)$ for a $n \times n$ block submatrix of rank r. This is done by first sampling the kernel function at new interpolation points, then selecting a subset of those using a CUR decomposition and finally using this reduced set of points as pivots for a RRLU-type factorization. We also explain how this implicitly builds an optimal interpolation basis for the Kernel under consideration. We show the asymptotic convergence of the algorithm, explain his stability and demonstrate on numerical examples that it performs very well in practice, allowing to obtain rank nearly equal to the optimal rank at a fraction of the cost of the naive algorithm.
Structural characterization and immunosuppressive activity of a new pregnane glycoside from Epigynum cochinchinensis
Creators: name: Shao, Yu-Ting
name: Zhao, Yan
name: Zhang, Hong
name: Jiang, Meng-Jun
name: Khan, Afsar
name: Cai, Sheng-Bao
name: Zhao, Tian-Rui
name: Cheng, Gui-Guang
name: Cao, Jian-Xin
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Phytochemical investigation on the ethyl acetate fraction of the leaves of Epigynum cochinchinensis led to the isolation of a new C21 pregnane glycoside, epigycoside B (1), together with three known analogues. Their structures were elucidated on the basis of extensive spectroscopic techniques, including UV, MS, and NMR experiments, as well as the chemical methods. Compound 1 displayed in vitro immunosuppressive activity against concanavalin A (Con A)/Lipopolysaccharides (LPS)-stimulated proliferation of mice splenocyte. The activity was significant as compared with control group at 50 μM concentration.
Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.
Creators: name: Sanchez, Mateo I
name: Vries, Laura E De
name: Lehmann, Christine
name: Lee, Jeong T
name: Ang, Kenny K
name: Wilson, Christopher
name: Chen, Steven
name: Arkin, Michelle R
name: Bogyo, Matthew
name: Deu, Edgar
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Model organisms
Biochemistry & Proteomics
Infectious Disease
Cell Biology
Computational & Systems Biology

description: Dipeptidyl aminopeptidases (DPAPs) are cysteine proteases that cleave dipeptides from the N-terminus of protein substrates and have been shown to play important roles in many pathologies including parasitic diseases such as malaria, toxoplasmosis and Chagas's disease. Inhibitors of the mammalian homologue cathepsin C have been used in clinical trials as potential drugs to treat chronic inflammatory disorders, thus proving that these enzymes are druggable. In Plasmodium species, DPAPs play important functions at different stages of parasite development, thus making them potential antimalarial targets. Most DPAP inhibitors developed to date are peptide-based or peptidomimetic competitive inhibitors. Here, we used a high throughput screening approach to identify novel inhibitor scaffolds that block the activity of Plasmodium falciparum DPAP1. Most of the hits identified in this screen also inhibit Plasmodium falciparum DPAP3, cathepsin C, and to a lesser extent other malarial clan CA proteases, indicating that these might be general DPAP inhibitors. Interestingly, our mechanism of inhibition studies indicate that most hits are allosteric inhibitors, which opens a completely new strategy to inhibit these enzymes, study their biological function, and potentially develop new inhibitors as starting points for drug development.
Cancellation and homotopy rigidity of classical functors
Creators: name: Huang, Ruizhi
name: Wu, Jie
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55P65, 55P45, 55P35, 55P40, 55P30

description: We first show that simply connected co-$H$-spaces and connected $H$-spaces can be uniquely decomposed into prime factors in the homotopy category of pointed $p$-local spaces of finite type, which is used to develop a $p$-local version of Gray's correspondence between homotopy types of prime co-$H$-spaces and homotopy types of prime $H$-spaces, and the split fibration which connects them as well. Further, we use the unique decomposition theorem to study the homotopy rigidity problem for classic functors. Among others, we prove that $ΣΩ$ and $Ω$ are homotopy rigid on simply connected $p$-local co-$H$-spaces of finite type, and $ΩΣ$ and $Σ$ are homotopy rigid on connected $p$-local $H$-spaces of finite type.
A ROS multi-ontology references services: OWL reasoners and application prototyping issues
Creators: name: Buoncompagni, Luca
name: Capitanelli, Alessio
name: Mastrogiovanni, Fulvio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: 68T40

description: This paper introduces a ROS Multi Ontology References (ARMOR) service, a general-purpose and scalable interface between robot architectures and OWL reasoners. ARMOR addresses synchronisation and communication issues among heterogeneous and distributed software components. As a guiding scenario, we consider a prototyping approach for the use of symbolic reasoning in human-robot interaction applications.
description: Presented to the IEEE RO-MAN 2017 Workshop on "Autonomous Robot Ontology", Lisbon Portugal, August 28, 2017. Published in: Proceedings of the 5th Italian Workshop on Artificial Intelligence and Robotics (AIRO) A workshop of the XVII International Conference of the Italian Association for Artificial Intelligence (AIXIA), Trento, Italy (2018). CEUR-WS, Vol-2352, pages 36-41
A dynamic network perspective on the evolution of the use of multiple mobile instant messaging apps
Creators: name: Xu, Yu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Information Systems not elsewhere classified
Science Policy

description: Mobile instant messaging (MIM) services have emerged as digital platforms for closed and private modes of communication. The present study adopts a dynamic network approach to understanding how MIM apps are used in combination with each other. The changing patterns of cross-platform MIM use are reflected in the structural dynamics of the audience overlap network among 58 MIM apps over March 2019 to March 2021 period. The results of the separable temporal exponential random graph model indicated that the formation and persistence of audience overlap was explained by network self-organization and app reach, but not by app engagement. These effects were observed when app-level confounding factors were held constant.
Structural basis for Fullerene geometry in a human endogenous retrovirus capsid
Creators: name: Acton, Oliver
name: Grant, Tim
name: Nicastro, Giuseppe
name: Ball, Neil J
name: Goldstone, David C
name: Robertson, Laura E
name: Sader, Kasim
name: Nans, Andrea
name: Ramos, Andres
name: Stoye, Jonathan P
name: Taylor, Ian A
name: Rosenthal, Peter B
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Model organisms
Imaging
Genetics & Genomics
Structural Biology & Biophysics
Cell Biology
Infectious Disease
Ecology,Evolution & Ethology

description: The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores.
Additional file 4: of Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family
Creators: name: Sieben, Anne
name: Mossevelde, Sara Van
name: Wauters, Eline
name: Engelborghs, Sebastiaan
name: Zee, Julie Van Der
name: Langenhove, Tim Van
name: Santens, Patrick
name: Praet, Marleen
name: Boon, Paul
name: Miatton, Marijke
name: Hoecke, Sofie Van
name: Vandenbulcke, Mathieu
name: Vandenberghe, Rik
name: Cras, Patrick
name: Cruts, Marc
name: Deyn, Peter De
name: Broeckhoven, Christine Van
name: Jean-Jacques Martin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Results: imaging data. (DOCX 16 kb)
Extraction, purification and antioxidant activity of novel polysaccharides from Dendrobium officinale by deep eutectic solvents
Creators: name: Liang, Jing
name: Zeng, Yingjie
name: Wang, Hongfeng
name: Lou, Wenyong
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Two novel polysaccharides DOP1-DES and DOP2-DES with molecular weight of 297,911 Da and 30,400 Da were extracted by using DESs from Dendrobium officinale for the first time, and purified with macroporous resin AB-8, Sephadex G75 and Sephadex G200 chromatography. Besides, the effect of extraction temperature, molar ratio of DES, reaction time and compound enzymes concentration on the extraction yield of polysaccharides were investigated. Monosaccharide composition analysis showed DOP1-DES and DOP2-DES were composed of D-glucose and D-mannose with the ratio of 2.2:1 and 3.7:1, respectively. Structural features of DOP1-DES and DOP2-DES were investigated by a combination of FT-IR, methylation analysis and NMR, which indicated that both polysaccharides had a similarly backbone consisting of (1, 4)-linked β-D-Manp and (1, 4)-linked β-D-Glcp with different ratio. Simultaneously, the two fractions possessed considerable antioxidant activity.
Unlocking Mare Infertility: A Systematic Approach to Diagnosis and Treatment
Creators: name: Bhautik Saripadiya, Naiya Parikh
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Infertility is the most common reproductive complaint of horse owners. It can be a perplexing problem for the veterinarian as identification of the cause is frequently difficult. Owners may not keep accurate records, the mare may change owners often, the stallion may be infertile, or reproductive management may be poor. Decreased pregnancy rates may be due to logistical problems such as an inappropriate breeding to ovulation interval because of limited stallion (Thoroughbred-natural mating) or semen availability (cooled shipped semen limited to3 days/week). Infertility may seem to be an irresolvable problem, however, if one approaches each mare in a systematic manner the majority of infertile mares can be diagnosed.
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Creators: name: Novellasdemunt, Laura
name: Kucharska, Anna
name: Jamieson, Cara
name: Prange-Barczynska, Maria
name: Baulies, Anna
name: Antas, Pedro
name: Vaart, Jelte Van Der
name: Gehart, Helmuth
name: Maurice, Madelon M
name: Li, Vivian SW
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Stem Cells
Developmental Biology
Human Biology & Physiology
Tumour Biology
Signalling & Oncogenes

description: The intestinal stem cell (ISC) marker LGR5 is a receptor for R-spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO receptor LGR5 expression. Despite its pivotal role in homeostasis, regeneration and cancer, little is known about the post-translational regulation of LGR5. Here, we show that the HECT-domain E3 ligases NEDD4 and NEDD4L are expressed in the crypt stem cell regions and regulate ISC priming by degrading LGR receptors. Loss of Nedd4 and Nedd4l enhances ISC proliferation, increases sensitivity to RSPO stimulation and accelerates tumour development in Apcmin mice with increased numbers of high-grade adenomas. Mechanistically, we find that both NEDD4 and NEDD4L negatively regulate Wnt/β-catenin signalling by targeting LGR5 receptor and DVL2 for proteasomal and lysosomal degradation. Our findings unveil the previously unreported post-translational control of LGR receptors via NEDD4/NEDD4L to regulate ISC priming. Inactivation of NEDD4 and NEDD4L increases Wnt activation and ISC numbers, which subsequently enhances tumour predisposition and progression.
Neolignan glycosides from Spiraea salicifolia and their inhibitory activity on pro-inflammatory cytokine interleukin-6 production in lipopolysaccharide-stimulated RAW 264.7 cells
Creators: name: Sun, Shiwei
name: Liu, Yang
name: Liu, Xiaohong
name: Zhang, Shuang
name: Wang, Wei
name: Wang, Rongrong
name: Hou, Yuxue
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Phytochemical investigation of the ethanol extract from the roots of Spiraea salicifolia L. (Rosaceae) led to the isolation of one new neolignan glycoside, (7S,8R)-3,5-dimethoxy-4′,7-epoxy-8,5′-neolignan-3′,4,9,9′-tetraol 9-O-α-L-rhamnopyranoside (1), along with two known neolignan glycosides, (7S,8R)-3-methoxy-4′,7-epoxy-8,5′-neolignan-3′,4,9,9′-tetraol 9-O-α-L-rhamnopyranoside (2) and (7R,8S)-dihydrodehydrodiconiferyl alcohol 9′-O-β-d-glucopyranoside (3). The structural characterisations of the isolated compounds were elucidated by spectroscopic data and comparison with the literatures reported on the chemical constituents from Juniperus communis var. depressa. All compounds were isolated for the first time from the Spiraea genus. Furthermore, the isolated compounds were subjected to assay inhibitory activity on pro-inflammatory cytokine interleukin-6 production in lipopolysaccharide-stimulated RAW 264.7 cells and all the compounds showed anti-inflammatory effects.
Additional file 1: of Applying GRADE-CERQual to qualitative evidence synthesis findingsâ paper 4: how to assess coherence
Creators: name: Colvin, Christopher
name: Garside, Ruth
name: Wainwright, Megan
name: Munthe-Kaas, Heather
name: Glenton, Claire
name: Bohren, Meghan
name: Carlsen, Benedicte
name: ĂZge TunĂ§Alp
name: Noyes, Jane
name: Booth, Andrew
name: Rashidian, Arash
name: Flottorp, Signe
name: Lewin, Simon
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Key definitions relevant to CERQual. (PDF 619 kb)
Additional file 1 of Modelling new insecticide-treated bed nets for malaria-vector control: how to strategically manage resistance?
Creators: name: Madgwick, Philip G.
name: Kanitz, Ricardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Comparison of methods between this study and Levick et al. [17].
Half-BPS Wilson loop and AdS$_2$/CFT$_1$
Creators: name: Giombi, Simone
name: Roiban, Radu
name: Tseytlin, Arkady A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study correlation functions of local operator insertions on the 1/2-BPS Wilson line in ${\cal N}=4$ super Yang-Mills theory. These correlation functions are constrained by the 1d superconformal symmetry preserved by the 1/2-BPS Wilson line and define a defect CFT$_1$ living on the line. At strong coupling, a set of elementary operator insertions with protected scaling dimensions correspond to fluctuations of the dual fundamental string in AdS$_5 \times S^5$ ending on the line at the boundary and can be thought of as light fields propagating on the AdS$_2$ worldsheet. We use AdS/CFT techniques to compute the tree-level AdS$_2$ Witten diagrams describing the strong coupling limit of the four-point functions of the dual operator insertions. Using the OPE, we also extract the leading strong coupling corrections to the anomalous dimensions of the "two-particle" operators built out of elementary excitations. In the case of the circular Wilson loop, we match our results for the 4-point functions of a special type of scalar insertions to the prediction of localization to 2d Yang-Mills theory.
description: 29 pages, 2 figures. v5: typos corrected
Shame, suicidal ideation, and urges for non-suicidal self-injury: the mediating role of anger
Creators: name: Weatherford, Jessica
Publisher: name: No Publisher Supplied
Year: 2024

description: Self-injurious thoughts and behaviors (SITB) are particularly prevalent within the diagnosis of borderline personality disorder (BPD). Shame has been shown to occur more frequently among individuals with BPD and shame-proneness predicts non-suicidal self-injury (NSSI), suicidal ideation (SI), and suicidal behaviors beyond BPD symptom severity. Moreover, anger and anger rumination may also play significant roles in processes related to shame and SITB, as they appear to mediate the relationship between shame and BPD symptoms. To date, these relationships have not been examined within a clinical sample of individuals who meet criteria for BPD. The present study has three aims: 1) to examine the relationships between shame, anger, and SITB urges in a treatment-seeking BPD sample; 2) to investigate the potential mediating role of anger on the relationship between shame and SITB urges; and 3) to conduct an exploratory analysis on whether a global measure of shame or daily reported shame is more closely related to daily reported SI and urges for NSSI. It is hypothesized that (1) higher daily levels of shame and anger independently will be associated with SI and NSSI urges; and (2) daily ratings of anger will mediate the relationship between daily ratings of shame intensity and SI and NSSI urges. Participants were 110 clients who meet criteria for BPD and who were engaged in treatment at a 6-month DBT research and training clinic at Rutgers University (DBT-RU). Daily diary card ratings were analyzed utilizing multi-level mediation to examine the relationships between variables. Results provided support for both hypotheses. Daily ratings of shame and anger were significantly associated with daily ratings of suicidal ideation and urges for NSSI. Furthermore, anger acted as a partial mediator between shame and SI as well as urges for NSSI. Global ratings of shame were not significantly associated with either suicidal ideation or urges for NSSI. This study contributes both to an understanding of emotion states and patterns that predict SITB within a BPD population. This study also points clinicians and administrators towards potential assessments and interventions in efforts to decrease SITB within a treatment setting.
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing.
Creators: name: Perez-Rodriguez, Diego
name: Kalyva, Maria
name: Leija-Salazar, Melissa
name: Tammaryn Lashley
name: Tarabichi, Maxime
name: Chelban, Viorica
name: Gentleman, Steve
name: Schottlaender, Lucia
name: Franklin, Hannah
name: Vasmatzis, George
name: Houlden, Henry
name: Schapira, Anthony HV
name: Warner, Thomas T
name: Holton, Janice L
name: Jaunmuktane, Zane
name: Proukakis, Christos
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Genetics & Genomics
Human Biology & Physiology
Ecology,Evolution & Ethology
Tumour Biology
Computational & Systems Biology

description: Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson's disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-synuclein) copy number variants (CNVs, specifically gains) in synucleinopathies, using Fluorescent in-situ Hybridisation for SNCA, and single-cell whole genome sequencing for the first time in a synucleinopathy. In the cingulate cortex, mosaicism levels for SNCA gains were higher in MSA and PD than controls in neurons (> 2% in both diseases), and for MSA also in non-neurons. In MSA substantia nigra (SN), we noted SNCA gains in > 3% of dopaminergic (DA) neurons (identified by neuromelanin) and neuromelanin-negative cells, including olig2-positive oligodendroglia. Cells with CNVs were more likely to have α-synuclein inclusions, in a pattern corresponding to cell categories mostly relevant to the disease: DA neurons in Lewy-body cases, and other cells in the striatonigral degeneration-dominant MSA variant (MSA-SND). Higher mosaicism levels in SN neuromelanin-negative cells may correlate with younger onset in typical MSA-SND, and in cingulate neurons with younger death in PD. Larger sample sizes will, however, be required to confirm these putative findings. We obtained genome-wide somatic CNV profiles from 169 cells from the substantia nigra of two MSA cases, and pons and putamen of one. These showed somatic CNVs in ~ 30% of cells, with clonality and origins in segmental duplications for some. CNVs had distinct profiles based on cell type, with neurons having a mix of gains and losses, and other cells having almost exclusively gains, although control data sets will be required to determine possible disease relevance. We propose that somatic SNCA CNVs may contribute to the aetiology and pathogenesis of synucleinopathies, and that genome-wide somatic CNVs in MSA brain merit further study.
Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica
Creators: name: Yang, Qin
name: Yao, Qing-Shou
name: Kuang, Yi
name: Zhang, Yue-Zhi
name: Feng, Ling-Ling
name: Zhang, Lu
name: Guo, Lin
name: Xie, Ze-Ping
name: Zhang, Shu-Min
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Juglonols A−C (1−3), three new juglone derivatives possessing a hydroxyethyl side chain, were isolated from an organic extract of the immature exocarps of Juglans mandshurica together with five known tetralones (4–8). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The new juglone derivatives exhibited inhibitory activities towards a panel of bacteria and fungi, as well as cancer cell lines. In contrast, the known tetralone homologues (4−8) appeared to be much less efficacy.
title: Dalla giustizia spaziale alla “giustizia” delle città e dei territori
Creators: name: De Donno, Marzia
Publisher: name: Italian Society for Law and Literature (ISLL)
Year: 2024

description: [From Spatial Justice to the “Justice” of Cities and Territories] Partendo dalle teorie sulla spatial justice e sulla legal geography elaborate in altri settori delle scienze sociali, con il contributo si sviluppano alcune riflessioni in ordine ad una loro traduzione giuridica nell’ambito dei processi di riforma e di riordino territoriale attualmente in atto nel nostro Paese. Soprattutto alla luce della tendenza, sviluppatasi a livello europeo, di definire e incentivare sistemi di governance territoriale differenziati e improntati a forme di cooperazione di tipo policentrico (c.d. functional regions), in conclusione si punta a dimostrare come un simile modello, anche tramite la relativizzazione dei confini amministrativi e il superamento di disparità territoriali che si coagulano all’interno dei territori – urbani e rurali –, possa essere preso concretamente in considerazione per assicurare la “giustizia” nei e tra i territori.
Additional file 2: of Applying GRADE-CERQual to qualitative evidence synthesis findingsâ paper 6: how to assess relevance of the data
Creators: name: Noyes, Jane
name: Booth, Andrew
name: Lewin, Simon
name: Carlsen, Benedicte
name: Glenton, Claire
name: Colvin, Christopher
name: Garside, Ruth
name: Bohren, Meghan
name: Rashidian, Arash
name: Wainwright, Megan
name: ĂZge TunĎAlp
name: Chandler, Jacqueline
name: Flottorp, Signe
name: Pantoja, Tomas
name: Tucker, Joseph
name: Munthe-Kaas, Heather
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Plant Biology

description: External relevance of data. (PDF 643Â kb)
Additional file 3: of Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family
Creators: name: Sieben, Anne
name: Mossevelde, Sara Van
name: Wauters, Eline
name: Engelborghs, Sebastiaan
name: Zee, Julie Van Der
name: Langenhove, Tim Van
name: Santens, Patrick
name: Praet, Marleen
name: Boon, Paul
name: Miatton, Marijke
name: Hoecke, Sofie Van
name: Vandenbulcke, Mathieu
name: Vandenberghe, Rik
name: Cras, Patrick
name: Cruts, Marc
name: Deyn, Peter De
name: Broeckhoven, Christine Van
name: Jean-Jacques Martin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 60506 Virology

description: Results: clinical and neuropsychological assessment. (DOCX 24 kb)
Additional file 2 of Modelling new insecticide-treated bed nets for malaria-vector control: how to strategically manage resistance?
Creators: name: Madgwick, Philip G.
name: Kanitz, Ricardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Figure legends for supporting conditional inference trees.
MOESM1 of Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography
Creators: name: Kim, Chang
name: Ingato, Dominique
name: Wilder-Smith, Petra
name: Zhongping Chen
name: Kwon, Young
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 1. Additional figures and tables.
The vanishing cycles of curves in toric surfaces II
Creators: name: Crétois, Rémi
name: Lang, Lionel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14M25, 20F38, 32S30

description: We resume the study initiated in \cite{CL}. For a generic curve $C$ in an ample linear system $\vert \mathcal{L} \vert$ on a toric surface $X$, a vanishing cycle of $C$ is an isotopy class of simple closed curve that can be contracted to a point along a degeneration of $C$ to a nodal curve in $\vert \mathcal{L} \vert$. The obstructions that prevent a simple closed curve in $C$ from being a vanishing cycle are encoded by the adjoint line bundle $K_X \otimes \mathcal{L}$. In this paper, we consider the linear systems carrying the two simplest types of obstruction. Geometrically, these obstructions manifest on $C$ respectively as an hyperelliptic involution and as a Spin structure. In both cases, we determine all the vanishing cycles by investigating the associated monodromy maps, whose target space is the mapping class group $MCG(C)$. We show that the image of the monodromy is the subgroup of $MCG(C)$ preserving respectively the hyperelliptic involution and the Spin structure. In particular, we provide an explicit finite set of generators for the Spin mapping class group. The results obtained here support the Conjecture $1$ in \cite{CL} aiming to describe all the vanishing cycles for any pair $(X, \mathcal{L})$.
description: 20 pages, 6 figures, main proofs simplified
Convergence analysis of quasi-Monte Carlo sampling for quantile and expected shortfall
Creators: name: He, Zhijian
name: Wang, Xiaoqun
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65D30, 65C05

description: Quantiles and expected shortfalls are usually used to measure risks of stochastic systems, which are often estimated by Monte Carlo methods. This paper focuses on the use of quasi-Monte Carlo (QMC) method, whose convergence rate is asymptotically better than Monte Carlo in the numerical integration. We first prove the convergence of QMC-based quantile estimates under very mild conditions, and then establish a deterministic error bound of $O(N^{-1/d})$ for the quantile estimates, where $d$ is the dimension of the QMC point sets used in the simulation and $N$ is the sample size. Under certain conditions, we show that the mean squared error (MSE) of the randomized QMC estimate for expected shortfall is $o(N^{-1})$. Moreover, under stronger conditions the MSE can be improved to $O(N^{-1-1/(2d-1)+ε})$ for arbitrarily small $ε>0$.
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression.
Creators: name: Kazachenka, Anastasiya
name: Young, George R
name: Attig, Jan
name: Kordella, Chrysoula
name: Lamprianidou, Eleftheria
name: Zoulia, Emmanuela
name: Vrachiolias, George
name: Papoutselis, Menelaos
name: Bernard, Elsa
name: Papaemmanuil, Elli
name: Kotsianidis, Ioannis
name: Kassiotis, George
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: subject: Model organisms
subject: Genetics & Genomics
subject: Structural Biology & Biophysics
subject: Infectious Disease
subject: Ecology,Evolution & Ethology
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational & Systems Biology

description: BACKGROUND: Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement in half of treated patients. Although the mechanisms underlying therapy success are not yet clear, induction of endogenous retroelements (EREs) has been hypothesised. METHODS: Using RNA sequencing (RNA-seq), we compared the transcription of EREs in bone marrow HSCs from a new cohort of MDS and chronic myelomonocytic leukaemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and AML patients. We further examined ERE transcription using the most comprehensive annotation of ERE-overlapping transcripts expressed in HSCs, generated here by de novo transcript assembly and supported by full-length RNA-seq. RESULTS: Consistent with prior reports, we found that treatment with 5-AZA increased the representation of ERE-derived RNA-seq reads in the transcriptome. However, such increases were comparable between treatment responses and failures. The extended view of HSC transcriptional diversity offered by de novo transcript assembly argued against 5-AZA-responsive EREs as determinants of the outcome of therapy. Instead, it uncovered pre-treatment expression and alternative splicing of developmentally regulated gene transcripts as predictors of the response of MDS and CMML patients to 5-AZA treatment. CONCLUSIONS: Our study identifies the developmentally regulated transcriptional signatures of protein-coding and non-coding genes, rather than EREs, as correlates of a favourable response of MDS and CMML patients to 5-AZA treatment and offers novel candidates for further evaluation.
Additional file 3 of Modelling new insecticide-treated bed nets for malaria-vector control: how to strategically manage resistance?
Creators: name: Madgwick, Philip G.
name: Kanitz, Ricardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Supporting conditional inference trees.
Additional file 7: Table S2. of The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies
Creators: name: Ando, Toshiya
name: Fujiwara, Haruhiko
name: Kojima, Tetsuya
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Sequences of siRNA used in RNAi experiments. (PDF 271Â kb)
Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829
Creators: name: Niaz, Shah-Iram
name: Zhang, Panpan
name: Shen, Hongjie
name: Li, Jing
name: Chen, Bin
name: Chen, Senhua
name: Liu, Lan
name: He, Jianguo
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Seven polyketides, including two new isochromanes, penisochromanes A and B (1 and 2), as well as five known compounds were obtained from an ascidian-derived fungus Penicillium sp. 4829. Their structures were identified by extensive spectroscopic analyses. The structures of compounds 1 and 3 were further determined by the X-ray crystallography. Compounds 1 and 2 were the first example of isochromane with three adjacent oxy substituents in natural source. Compound 4 exhibited selective activities against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, with MIC values 6.25 and 12.5 μM, respectively.
Spectral Form Factor in Non-Gaussian Random Matrix Theories
Creators: name: Gaikwad, Adwait
name: Sinha, Ritam
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider Random Matrix Theories with non-Gaussian potentials that have a rich phase structure in the large $N$ limit. We calculate the Spectral Form Factor (SFF) in such models and present them as interesting examples of dynamical models that display multi-criticality at short time-scales and universality at large time scales. The models with quartic and sextic potentials are explicitly worked out. The disconnected part of the Spectral Form Factor (SFF) shows a change in its decay behavior exactly at the critical points of each model. The dip-time of the SFF is estimated in each of these models. The late time behavior of all polynomial potential matrix models is shown to display a certain universality. This is related to the universality in the short distance correlations of the mean-level densities. We speculate on the implications of such universality for chaotic quantum systems including the SYK model.
description: Introduction modified, section 2 moved to the Appendix, main text slightly modified, section on Paley-Wiener theorem omitted, new perspective on the results provided in sec V, typos corrected, footnotes added, references added, conclusion unchanged