cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm
Creators: name: O'Shea, Thomas M.
name: Stafstrom, Carl E.
name: Hirschberger, Rachel G.
name: Jara, Hernan
name: Kuban, Karl C.K.
name: Heeren, Tim
name: Paneth, Nigel
name: ELGAN Study Investigators
name: Hirtz, Deborah
name: Rollins, Julie V.
name: Douglass, Laurie M.
name: Joseph, Robert M.
name: Frazier, Jean A.
Publisher: name: Elsevier
Year: 2017

description: BACKGROUND: This study aims to determine the prevalence of neurodevelopmental impairments at age ten years among children born extremely preterm (less than 28 weeks gestational age) and to offer a framework for categorizing neurological limitations. METHODS: A multicenter, prospective cohort follow-up study recruited 889 ten-year-old children born from 2002 to 2004. We assessed prevalence of cognitive impairment, measured by intelligent quotient and tests of executive function, cerebral palsy (CP), autism spectrum disorder (ASD), and epilepsy singly and in combination. The three levels of impairment severity were: category I-no major neurodevelopmental impairment; category II-normal cognitive ability with CP, ASD, and/or epilepsy; and category III-children with cognitive impairment. RESULTS: A total 214 of 873 children (25%) had cognitive impairment, 93 of 849 children (11%) had CP, 61 of 857 children (7%) had ASD, and 66 of 888 children (7%) had epilepsy. Further, 19% of all children had one diagnosis, 10% had two diagnoses, and 3% had three diagnoses. Decreasing gestational age was associated with increasing number of impairments (PÂ <Â 0.001). Half the children with cognitive impairment and one third of children with CP, ASD, or epilepsy had a single impairment. Six hundred one (68% [95% CI, 64.5%-70.7%]) children were in category I, 74 (8% [95% CI, 6.6%-10.3%]) were in category II, and 214 (24% [95% CI 21.7%-27.4%]) were in category III. CONCLUSIONS: Three quarters of children had normal intellect at age ten years; nearly 70% were free of neurodevelopmental impairment. Forty percent of children with impairments had multiple diagnoses.
Cercophis auratus
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Cercophis
Cercophis auratus

description: Cercophis auratus (Schlegel, 1837)
Type locality. Suriname, restricted to surroundings of Paramaribo by Hoogmoed et al. (2019).
Distribution. Known in Brazil, and Suriname, mostly along coastal forested areas of South America (Plt. 410A). In Brazil, widespread in southern and central Atlantic Forest, as well as in eastern Pará (Plt. 410A), at low elevations (Plt. 410B). Map and taxonomy in Hoogmoed et al. (2019). Observed in the field in forest (Pontes et al., 2008).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 48, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Lioheterophis iheringi Amaral 1936
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Lioheterophis
Lioheterophis iheringi

description: Lioheterophis iheringi Amaral, 1936
Type locality. Campina Grande, state of Paraíba, Brazil.
Distribution. Endemic to Brazil (Plt. 411A). Known from a single locality within the Caatinga (Plt. 411A) at intermediate elevations (Plt. 411B). No detailed field data on habitat use for this species.
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 48, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm
Creators: name: Allred, Elizabeth N.
name: Leviton, Alan
name: Fichorova, Raina N.
name: Dammann, Olaf
name: Joseph, Robert M.
name: O'Shea, T. Michael
name: Kuban, Karl C.K.
Publisher: name: Wiley
Year: 2018

description: 
Background

Difficulties with reading and math occur more commonly among children born extremely preterm than among children born at term. Reasons for this are unclear.
Methods

We measured the concentrations of 27 inflammatory-related and neurotrophic/angiogenic proteins (angio-neurotrophic proteins) in multiple blood specimens collected a week apart during the first postnatal month from 660 children born before the 28th week of gestation who at age 10 years had an IQ ≥ 70 and a Wechsler Individual Achievement Test 3rd edition (WIAT-III) assessment. We identified four groups of children, those who had a Z-score ≤ −1 on the Word Reading assessment only, on the Numerical Operations assessment only, on both of these assessments, and on neither, which served as the referent group. We then modeled the risk of each learning limitation associated with a top quartile concentration of each protein, and with high and lower concentrations of multiple proteins.
Results

The protein profile of low reading scores was confined to the third and fourth postnatal weeks when increased risks were associated with high concentrations of IL-8 and ICAM-1 in the presence of low concentrations of angio-neurotrophic proteins. The profile of low math scores was very similar, except it did not include ICAM-1. In contrast, the profile of low scores on both assessments was present in each of the first four postnatal weeks. The increased risks associated with high concentrations of TNF-α in the first two weeks and of IL-8 and ICAM-1 in the next two weeks were modulated down by high concentrations of angio-neurotrophic proteins.
Conclusions

High concentrations of angio-neurotrophic proteins appear to reduce/moderate the risk of each learning limitation associated with systemic inflammation. The three categories of limitations have protein profiles with some similarities, and yet some differences, too.
Test Materials And Geometries Selection. Proposed Thermo-Mechanical Behaviour
Creators: name: Lalau, Y
name: Guillot, E.
Publisher: name: Zenodo
Year: 2015
Subjects: concentrated solar power
refractory ceramic
thermo-mechanical behaviour
acoustic emission

description: The work presented here focus on the selection of the samples to validate these new instruments and methods based on acoustic measurements. This selection is made by studying the acoustic and thermo-mechanical properties of the test materials.

After a brief introduction, the materials properties experimentally measured are summarized. Then, the solar setup and the new measurement methods to be developed are presented. This presentation of the development direction is required to allow the reader understands which variables are needed to be studied to determine the optimal sample size: this optimisation process is the fourth and main part of this report, followed by this work conclusion.
Acerodon Jourdan 1837
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon

description: Acerodon Jourdan 1837
Acerodon Jourdan 1837, L'Echo du Monde Savant, 4 (No. 275): 156.
Type Species: Pteropus jubatus Eschscholtz 1831
Species and subspecies: 5 species with 10 subspecies:
Species Acerodon celebensis Peters 1867
Species Acerodon humilis K. Andersen 1909
Species Acerodon jubatus (Eschscholtz 1831)
Subspecies Acerodon jubatus subsp. jubatus Eschscholtz 1831
Subspecies Acerodon jubatus subsp. lucifer Elliot 1896
Subspecies Acerodon jubatus subsp. mindanensis K. Andersen 1909
Species Acerodon leucotis Sanborn 1950
Subspecies Acerodon leucotis subsp. leucotis Sanborn 1950
Subspecies Acerodon leucotis subsp. obscurus Sanborn 1950
Species Acerodon mackloti Temminck 1837
Subspecies Acerodon mackloti subsp. mackloti Temminck 1837
Subspecies Acerodon mackloti subsp. alorensis K. Andersen 1909
Subspecies Acerodon mackloti subsp. floresii Gray 1871
Subspecies Acerodon mackloti subsp. gilvus K. Andersen 1909
Subspecies Acerodon mackloti subsp. prajae Sody 1936
Discussion: Very closely related to and possibly congeneric with Pteropus; see Musser et al. (1982 a) and Corbet and Hill (1992).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage
Creators: name: Fichorova, Raina N.
name: Leviton, Alan
name: Fordham, Lynn A.
name: O'Shea, T. Michael
name: Allred, Elizabeth N.
name: Dammann, Olaf
name: Kuban, Karl K.C.
Publisher: name: Elsevier
Year: 2018

description: AIM: To assess to what extent the blood concentrations of proteins with neurotrophic and angiogenic properties measured during the first postnatal month convey information about the risk of sonographically-identified brain damage among very preterm newborns. METHODS: Study participants were 1219 children who had a cranial ultrasound scan during their stay in the intensive care nursery and blood specimens collected on 2 separate days at least a week apart during the first postnatal month. Concentrations of selected proteins in blood spots were measured with electrochemiluminescence or with a multiplex immunobead assay and the risks of cranial ultrasound images associated with top-quartile concentrations were assessed. RESULTS: High concentrations of multiple inflammation-related proteins during the first 2 postnatal weeks were associated with increased risk of ventriculomegaly, while high concentrations of just 3 inflammation-related proteins were associated with increased risk of an echolucent/hypoechoic lesion (IL-6, IL-8, ICAM-1), especially on day 7. Concomitant high concentrations of IL6R and bFGF appeared to modulate the increased risks of ventriculomegaly and an echolucent lesion associated with inflammation. More commonly high concentrations of putative protectors/repair-enhancers did not appear to diminish these increased risks. CONCLUSION: Our findings provide support for the hypothesis that endogenous proteins are capable of either protecting the brain against damage and/or enhancing repair of damage.
Acerodon celebensis Peters 1867
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon celebensis

description: Acerodon celebensis Peters 1867
Acerodon celebensis Peters 1867, Monatsb. K. Preuss. Akad. Wiss. Berlin, 1867: 333.
Type Locality: Indonesia, Sulawesi.
Vernacular Names: Sulawesi Fruit Bat.
Synonyms: Acerodon arquatus Miller and Hollister 1921.
Distribution: Sulawesi, Saleyer Isl, Sangihe Isls, Sula Isls (Indonesia).
Conservation: CITES – Appendix II. IUCN / SSC Action Plan (1992) – No data. IUCN 2003 – Lower Risk (nt).
Discussion: Includes arquatus and Sulawesi specimens formerly in Pteropus argentatus (see Musser et al., 1982 a). Also see Flannery (1995 b).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Acerodon humilis K. Andersen 1909
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon humilis

description: Acerodon humilis K. Andersen 1909
Acerodon humilis K. Andersen 1909, Ann. Mag. Nat. Hist., ser. 7, 3: 24-25.
Type Locality: Indonesia, Talaud Isls, Lirong.
Vernacular Names: Talaud Fruit Bat.
Distribution: Talaud Isls (Indonesia).
Conservation: CITES – Appendix II. IUCN / SSC Action Plan (1992) – No Data: Limited Distribution. IUCN 2003 – Vulnerable.
Discussion: Previously known only from the holotype, which Flannery (1995 b) suggested might be a chimera consisting of a mismatched skull from an individual of celebensis and a skin of a Pteropus hypomelanus However, Feiler (1990) described two additional museum specimens, and a living population of this taxon has recently been rediscovered (Riley, 2001). It appears to represent a distinct species.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
(Un)settled: Displacement in the Syrian Refugee Crisis and the Social Model of Disability
Creators: name: Srinivas, Shikha
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: College students' writings, disability studies, Syrian refugee crisis, narrative

description: This essay won or received an honorable mention for The Boothe Prize for excellence in first-year writing. The Boothe Prize recognizes and rewards outstanding expository and argumentative writing by undergraduate students in first-year classes that satisfy the WR 1 requirement. In each award-winning essay, student writers demonstrate clarity of argument, excellent integration of research-based evidence, and compelling prose style.
This essay applies a disabilities study lens to the Syrian refugee crisis, focusing on a population that receives scant attention from humanitarian aid groups: refugees with disabilities. Refugees already occupy a position of precarity, but refugees with disabilities, Shikha argues, demand a reevaluation of the social model of disability by considering its broader application to the experiences of displaced people.
Antenatal and neonatal antecedents of learning limitations in 10-year old children born extremely preterm
Creators: name: Allred, Elizabeth N.
name: Kuban, Karl K.C.
name: Leviton, Alan
name: Joseph, Robert M.
name: O'Shea, T. Michael
Publisher: name: Elsevier
Year: 2018

description: BACKGROUND: Children born extremely preterm are at increased risk of learning limitations. AIM: To identify the antecedents of learning limitations of children born extremely preterm. STUDY DESIGN: Prospective observational study from birth to age 10years. Variables entered into the multinomial logistic regression analyses were ordered temporally, with the earliest occurring predictors/covariates of each learning limitation risk entered first and not displaced by later occurring covariates. SUBJECTS: 874 children who were born before the 28th week of gestation. OUTCOME MEASURES: A reading limitation was defined as a score one or more standard deviations below the expected mean on the WIAT-III Word Reading and a mathematics limitation was defined as a similarly low score on the Numerical Operations component. RESULTS: 56 children had a "reading ONLY" limitation, 132 children had a "math ONLY" limitation and 89 children had "reading AND math" limitations. All risk profiles included an indicator of socioeconomic disadvantage (e.g., mother's "racial" identity and eligibility for government-provided health care insurance), an indicator of newborn's immaturity/vulnerability (e.g., high illness severity score, receipt of hydrocortisone, and/or ventilator-dependence at 36weeks post-menstruation), and all but the math only limitation included an indicator of fetal growth restriction and inflammation (i.e., pregnancy urinary tract infection or late ventilator-dependence). CONCLUSIONS: The themes of socioeconomic disadvantage and immaturity/vulnerability characterize all three risk profiles, while the themes of fetal growth restriction and inflammation are characteristic of a reading limitation only, and the reading and math limitations entity.
Acerodon jubatus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon jubatus

description: Acerodon jubatus (Eschscholtz 1831)
[Pteropus] jubatus Eschscholtz 1831, Zool. Atlas, Part 4: 1.
Type Locality: Philippines, Luzon, Manila.
Vernacular Names: Golden-capped Fruit Bat.
Subspecies::
Subspecies Acerodon jubatus subsp. jubatus Eschscholtz 1831
Subspecies Acerodon jubatus subsp. lucifer Elliot 1896
Subspecies Acerodon jubatus subsp. mindanensis K. Andersen 1909
Distribution: Philippines except Palawan region.
Conservation: CITES – Appendix I (and possibly extinct) as A. lucifer, Appendix I as A. jubatus; otherwise Appendix II; IUCN / SSC Action Plan (1992) and IUCN 2003 – Endangered as A. jubatus, A. lucifer listed as Extinct.
Discussion: Includes lucifer; see Ingle and Heaney (1992) and Heaney et al. (1998).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation
Creators: name: Kasten, Florian H
name: Negahbani, Ehsan
name: Herrmann, Christoph S
name: Fröhlich, Flavio
Publisher: name: Elsevier
Year: 2018

description: Non-invasive brain stimulation to target specific network activity patterns, e.g. transcranial alternating current stimulation (tACS), has become an essential tool to understand the causal role of neuronal oscillations in cognition and behavior. However, conventional sinusoidal tACS limits the ability to record neuronal activity during stimulation and lacks spatial focality. One particularly promising new tACS stimulation paradigm uses amplitude-modulated (AM) high-frequency waveforms (AM-tACS) with a slow signal envelope that may overcome the limitations. Moreover. AM-tACS using high-frequency carrier signals is more tolerable than conventional tACS, e.g. in terms of skin irritation and occurrence of phosphenes, when applied at the same current intensities (e.g. 1-2mA). Yet, the fundamental mechanism of neuronal target-engagement by AM-tACS waveforms has remained unknown. We used a computational model of cortex to investigate how AM-tACS modulates endogenous oscillations and compared the target engagement mechanism to the case of conventional (unmodulated) low-frequency tACS. Analysis of stimulation amplitude and frequency indicated that cortical oscillations were phase-locked to the envelope of the AM stimulation signal, which thus exhibits the same target engagement mechanism as conventional (unmodulated) low frequency tACS. However, in the computational model substantially higher current intensities were needed for AM-tACS than for low-frequency (unmodulated) tACS waveforms to achieve pronounced phase synchronization. Our analysis of the carrier frequency suggests that there might be a trade-off between the use of high-frequency carriers and the stimulation amplitude required for successful entrainment. Together, our computational simulations support the use of slow-envelope high frequency carrier AM waveforms as a tool for noninvasive modulation of brain oscillations. More empirical data will be needed to identify the optimal stimulation parameters and to evaluate tolerability and safety of both, AM- and conventional tACS.
Acerodon jubatus subsp. jubatus Eschscholtz 1831
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon jubatus
Acerodon jubatus subsp. jubatus eschscholtz 1831

description: Acerodon jubatus subsp. jubatus Eschscholtz 1831
Acerodon jubatus subsp. jubatus Eschscholtz 1831, Zool. Atlas, Part 4: 1.
Type Locality: Philippines, Luzon, Manila.
Synonyms: Acerodon jubatus subsp. aurinuchalis Elliot 1896; Acerodon jubatus subsp. pyrrhocephalus Meyen 1833.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Socioemotional dysfunctions at age 10 years in extremely preterm newborns with late-onset bacteremia
Creators: name: Bright, H. Reeve
name: Joseph, Robert M.
name: O'Shea, T. Michael
name: Allred, Elizabeth N.
name: Kuban, Karl C.K.
name: Erdei, Carmina
name: Leviton, Alan
name: Dammann, Olaf
name: Babata, Kikelomo
Publisher: name: Elsevier
Year: 2018

description: Children born extremely preterm (EP) are at a higher risk of social impairment than those born at term. These difficulties emerge early and persist throughout childhood.” Among EP children, the “preterm behavioral phenotype,” a constellation of disorders and symptoms characterized by anxiety, inattention, and social and communication, problems has been described. Some of these mental health disorders might account for the lower parent-reported health-related quality of life among extremely preterm infants than in their peers born at term.
Acerodon leucotis Sanborn 1950
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon leucotis

description: Acerodon leucotis Sanborn 1950
Acerodon leucotis Sanborn 1950, Proc. Biol. Soc. Wash., 63: 189.
Type Locality: Philippines, Calamianes Isls, Busuanga Isl, Singay.
Vernacular Names: Palawan Fruit Bat.
Subspecies::
Subspecies Acerodon leucotis subsp. leucotis Sanborn 1950
Subspecies Acerodon leucotis subsp. obscurus Sanborn 1950
Distribution: Balabac, Palawan, Busuanga Isl (Philippines).
Conservation: CITES – Appendix II. IUCN / SSC Action Plan (1992) – No Data. IUCN 2003 – Vulnerable.
Discussion: Formerly included in Pteropus (see Musser et al., 1982 a).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Neurocognitive and Health Correlates of Overweight and Obesity among Ten-Year-Old Children Born Extremely Preterm
Creators: name: Linthavong, Olivia
name: Leviton, Alan
name: Kuban, Karl C.K.
name: Bauserman, Melissa
name: O'Shea, T. Michael
name: Allred, Elizabeth
name: Joseph, Robert M.
name: Perrin, Eliana
name: Heeren, Timothy C.
Publisher: name: Elsevier
Year: 2018

description: OBJECTIVE: To assess the relationship between overweight (body mass index [BMI] percentile â‰¥85 and <95) and obesity (BMI â‰¥95 percentile) and developmental and health outcomes at 10 years of age in a cohort of individuals born extremely preterm. STUDY DESIGN: This was an observational cohort study of children born extremely preterm and then assessed at age 10 years for neurocognitive function and parent-reported behavior and health outcomes. Participants included 871 children aged 10 years. To describe the strength of association between overweight or obesity and outcomes, we used logistic regression models adjusting for confounders. Neurocognitive function, academic achievement, parent-reported health outcome surveys, and height and weight were measured. RESULTS: BMI category at 10 years of age was not associated with differences in intelligence, language, or academic achievement. Parents of children with obesity were more likely to report their child had asthma (OR 2.2; 95% CI 1.4-3.5), fair/poor general health (OR 3.2; 95% CI 1.4-7.5), and decreased physical function (OR 1.7; 95% CI 1.1-2.9) but less likely to have physician diagnosed attention-deficit/hyperactivity disorder (OR 0.5; 95% CI 0.3-0.97) or an individualized education plan (OR 0.6; 95% CI 0.4-0.99). CONCLUSION: Among children born extremely preterm, an elevated BMI, compared with normal or low BMI, is not associated with a difference in neurocognitive function. However, asthma, fair/poor general health, and decreased physical function were more prevalent among study participants with obesity, and attention-deficit/hyperactivity disorder and individualized education plan were less prevalent.
Maternal obesity and attention-related symptoms in the preterm offspring
Creators: name: Leviton, Alan
name: van der Burg, Jelske W.
name: van de Bor, Margot
name: O'Shea, T. Michael
name: Kuban, Karl
name: Hooper, Stephen R.
name: Scott, Megan
name: Allred, Elizabeth N.
name: Hunter, Scott
name: Dammann, Olaf
name: Jensen, Elizabeth T.
name: Joseph, Robert M.
Publisher: name: Elsevier
Year: 2017

description: Background

Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm.
Aim

To estimate the risk of attention problems at age 10 years in children born very preterm to overweight (i.e., body mass index (BMI) 25–29 kg/m2) and obese (i.e., BMI ≥ 30 kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI < 25 kg/m2).
Study design

Multi-center prospective cohort study.
Methods

A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ ≥ 70 at age 10 years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD.
Results

Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI < 25 kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR) = 1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR = 2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR = 1.0; 95% CI: 0.6, 1.8), or obese (OR = 1.0; 95% CI: 0.6, 1.6).
Conclusion

Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10 years of age in children born extremely preterm.
Acerodon leucotis subsp. leucotis Sanborn 1950
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon leucotis
Acerodon leucotis subsp. leucotis sanborn 1950

description: Acerodon leucotis subsp. leucotis Sanborn 1950
Acerodon leucotis subsp. leucotis Sanborn 1950, Proc. Biol. Soc. Wash., 63: 189.
Type Locality: Philippines, Calamianes Isls, Busuanga Isl, Singay.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Acerodon mackloti Temminck 1837
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon mackloti

description: Acerodon mackloti Temminck 1837
Acerodon mackloti Temminck 1837, Monogr. Mamm., Vol. 2: 69.
Type Locality: Indonesia, Timor.
Vernacular Names: Sunda Fruit Bat.
Subspecies::
Subspecies Acerodon mackloti subsp. mackloti Temminck 1837
Subspecies Acerodon mackloti subsp. alorensis K. Andersen 1909
Subspecies Acerodon mackloti subsp. floresii Gray 1871
Subspecies Acerodon mackloti subsp. gilvus K. Andersen 1909
Subspecies Acerodon mackloti subsp. prajae Sody 1936
Distribution: Lombok, Sumbawa, Flores, Alor Isl, Sumba, and Timor (Indonesia).
Conservation: CITES – Appendix II. IUCN / SSC Action Plan (1992) – Not Threatened; IUCN 2003 – Lower Risk (lc).
Discussion: The subspecies nomenclature of this taxon is in need of revision (Helgen and Wilson, 2002). This name is sometimes spelled macklotii.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Pegophysema bialata
Creators: name: Jirapatrasilp, Parin
name: Cuny, Gilles
name: Kocsis, László
name: Sutcharit, Chirasak
name: Ngamnisai, Nom
name: Charoentitirat, Thasinee
name: Kumpitak, Satapat
name: Suraprasit, Kantapon
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Bivalvia
Lucinida
Lucinidae
Pegophysema
Pegophysema bialata

description: Pegophysema bialata (Pilsbry, 1895)
Figs 13 E, 15 A
 Loripes bialata Pilsbry, 1895: 133 – 134, pl. 3, figs 13, 14. Type locality: Inland Sea, Japan.
 Anodontia (? Pegophysema) bialata. Taylor and Glover 2005: 305 – 306, figs 11 a, 12 a, 22, 23.
 Pegophysema bialata. Huber 2015: 102, 455 – 456, with in-text figs; C 10244. Wells et al. 2021: 35.
Referred material.
CUF - NKNY - B 11 (3 L + 3 R shells; Figs 13 E, 15 A).
Habitat.
Muddy bottoms and sandy mud among weed in intertidal zones down to 60 m depth (Huber 2015).
Distribution.
Indian Ocean; Indo-West Pacific, from Japan to Malaysia (Taylor and Glover 2005; Huber 2015).
Record in Thailand.
Gulf of Thailand (Wells et al. 2021).
Taxonomic remarks and comparisons.
 This species differs from its similar species, Pegophysema philippiana (Reeve, 1850), by having a ligament that is shallowly inset and an absence of secondary pallial attachment scars (Taylor and Glover 2005). See also comprehensive taxonomic remarks in Taylor and Glover (2005).
 Order Venerida Gray, 1854
  Superfamily Cyrenoidea Gray, 1840
description: Published as part of Jirapatrasilp, Parin, Cuny, Gilles, Kocsis, László, Sutcharit, Chirasak, Ngamnisai, Nom, Charoentitirat, Thasinee, Kumpitak, Satapat & Suraprasit, Kantapon, 2024, Mid-Holocene marine faunas from the Bangkok Clay deposits in Nakhon Nayok, the Central Plain of Thailand, pp. 1-110 in ZooKeys 1202 on pages 1-110, DOI: 10.3897/zookeys.1202.119389
A Collaborative Intelligence (CI) Framework for Fraud Detection in U.S. Federal Relief Programs
Creators: name: Das, Rahul
name: Sirazy, Md Riad Mahamud
name: Khan, Rafiqus Salehin
name: Rahman, Sharifur
Publisher: name: 2023 ResearchBerg Publishing Group
Year: 2023

description: Fraud in U.S. Federal Relief Programs poses significant

risks to government budgets, public trust, and the sustainability

of aid programs that are designed to shore

up communities and businesses across this crisis. We

argued that a dual approach, which brings together human

expertise and state-of-the-art Artificial Intelligence

techniques-often referred to as Collaborative Intelligence

(CI)-can offer a potent means for detecting, investigating,

and preventing such fraud at scale. The

proposed model connects many data sources, such as

government registries, payroll records, banking transactions,

and open-source intelligence in one central data

lake, for general oversight. In addition, the application

of machine learning algorithms is complemented

by graph analytics and natural language processing in

underlining various anomalies, such as documentation

falsification, misrepresentations regarding eligibility,

shell companies, and suspicious patterns of transactions.

These AI-generated alerts then get refined by investigators,

compliance officers, and auditors by investigating

high-risk cases and providing the models with additional

contextual knowledge. Moreover, solid governance

practices of privacy, security, and legal compliance

assure that the personal data of individuals are

handled in a responsible manner, along with the ethical

and lawful treatment of investigative processes. This

could strengthen integrity within relief programs and

safeguard much-needed financial assistance for legitimate

recipients.
Acerodon mackloti subsp. mackloti Temminck 1837
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon mackloti
Acerodon mackloti subsp. mackloti temminck 1837

description: Acerodon mackloti subsp. mackloti Temminck 1837
Acerodon mackloti subsp. mackloti Temminck 1837, Monogr. Mamm., Vol. 2: 69.
Type Locality: Indonesia, Timor.
Synonyms: Acerodon mackloti subsp. ochraphaeus Muller and Jentink 1887.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta
Creators: name: The ELGAN Study Investigators
name: Allred, Elizabeth N.
name: Joseph, Robert M.
name: Leviton, Alan
name: Majzoub, Joseph
name: O'Shea, Thomas Michael
name: Kuban, Karl C. K.
Publisher: name: Wiley
Year: 2018

description: AIM: To evaluate the relationship between corticotropin-releasing hormone (CRH) expression in the placenta and the risk of school-related dysfunctions at the age of 10 years among children born extremely preterm (EP). METHODS: Corticotropin-releasing hormone expression was measured in the placenta of 761 EP children, who had the following assessments at the age of 10 years: Differential Ability Scales, Oral and Written Language Scales, the Wechsler Individual Achievement Test-III, NEPSY-II and the Child Symptom Inventory-4. We evaluated whether lowest and highest quartiles of CRH mRNA were associated with undesirable scores on these assessments. With 272 evaluations, we would expect 14 to be significant at p < 0.05. RESULTS: Only 16 associations were statistically significant. On the other hand, seven of these were social limitations among girls whose placenta CRH mRNA was in the top quartile. Adjusting for delivery indication or restricting the sample to one delivery indication group resulted in few differences. CONCLUSION: Overall, placenta CRH mRNA concentrations in the top or bottom quartiles were not associated with increased risks of dysfunctions 10 years later. Girls whose placenta CRH expression was in the top quartile, however, were at increased risk of seven indicators/correlates of social limitations.
Teredinidae Rafinesque 1815
Creators: name: Jirapatrasilp, Parin
name: Cuny, Gilles
name: Kocsis, László
name: Sutcharit, Chirasak
name: Ngamnisai, Nom
name: Charoentitirat, Thasinee
name: Kumpitak, Satapat
name: Suraprasit, Kantapon
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Bivalvia
Myida
Teredinidae

description: Teredinidae indet.
Fig. 16 I
Referred material.
CUF - NKNY - B 14 - 4 (83 tube pieces; Fig. 16 I).
Habitat.
Boring into submerged wood and other plant material (Poutiers 1998 a).
Taxonomic remarks and comparisons.
The calcareous burrows have a septum dividing the cavity in half, indicating that these burrows belong to the shipworm family Teredinidae (e. g., Chan and Lau 2021). Due to the absence of shells, it is impossible to assign the inhabitants to species or even genus level based on these trace fossils.
 Order Adapedonta Cossmann & Peyrot, 1909
 Superfamily Solenoidea Lamarck, 1809
description: Published as part of Jirapatrasilp, Parin, Cuny, Gilles, Kocsis, László, Sutcharit, Chirasak, Ngamnisai, Nom, Charoentitirat, Thasinee, Kumpitak, Satapat & Suraprasit, Kantapon, 2024, Mid-Holocene marine faunas from the Bangkok Clay deposits in Nakhon Nayok, the Central Plain of Thailand, pp. 1-110 in ZooKeys 1202 on pages 1-110, DOI: 10.3897/zookeys.1202.119389
Acerodon mackloti subsp. floresii Gray 1871
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Acerodon
Acerodon mackloti
Acerodon mackloti subsp. floresii gray 1871

description: Acerodon mackloti subsp. floresii Gray 1871
Synonyms: Acerodon mackloti subsp. floresianus Heude 1896.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
Thalassina undetermined
Creators: name: Jirapatrasilp, Parin
name: Cuny, Gilles
name: Kocsis, László
name: Sutcharit, Chirasak
name: Ngamnisai, Nom
name: Charoentitirat, Thasinee
name: Kumpitak, Satapat
name: Suraprasit, Kantapon
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Thalassinidae
Thalassina
Thalassina undetermined

description: Thalassina sp.
Figs 13 I, 17 D
Referred material.
CUF - NKNY - O 09 (130 pieces; Figs 13 I, 17 D).
Habitat.
Littoral and sublittoral zones, mangrove swamps and forests, and edges of estuaries (Ngoc-Ho and de Saint Laurent 2009).
Distribution.
Indo-West Pacific, from Japan to Australia (Hyžný and de Angeli 2022). Records of fossils from the Miocene to Holocene in Indo-West Pacific, and from the Oligocene in Italy (Hyžný and de Angeli 2022).
Taxonomic remarks and comparisons.
 These specimens are assigned to Thalassina based on descriptions in Ngoc-Ho and de Saint Laurent (2009), Sakai and Türkay (2012), and Hyžný and de Angeli (2022), specifically in having a subchelate pereiopod 1 with its propodus having dorsomesially tuberculated or spinuous carinae. There is a total of 13 species within this genus (Hyžný and de Angeli 2022), in which three species, T. anomala (Herbst, 1804), T. gracilis Dana, 1852, and T. squamifera De Man, 1915, are recorded from Thailand (Ngoc-Ho and de Saint Laurent 2009; Sakai and Türkay 2012) (but see the comment on the record of T. squamifera in Thailand in Moh et al. (2013)). However, the pereiopod 1 observed in our specimens is shorter and has a more quadrate shape. The dactylus that has a hooked tip is nearly as long as the fixed finger, suggesting an as yet unidentified species.
 Class Thecostraca Gruvel, 1905
 Subclass Cirripedia Burmeister, 1834
 Order Balanomorpha Pilsbry, 1916
description: Published as part of Jirapatrasilp, Parin, Cuny, Gilles, Kocsis, László, Sutcharit, Chirasak, Ngamnisai, Nom, Charoentitirat, Thasinee, Kumpitak, Satapat & Suraprasit, Kantapon, 2024, Mid-Holocene marine faunas from the Bangkok Clay deposits in Nakhon Nayok, the Central Plain of Thailand, pp. 1-110 in ZooKeys 1202 on pages 1-110, DOI: 10.3897/zookeys.1202.119389
Megabalanus tintinnabulum
Creators: name: Jirapatrasilp, Parin
name: Cuny, Gilles
name: Kocsis, László
name: Sutcharit, Chirasak
name: Ngamnisai, Nom
name: Charoentitirat, Thasinee
name: Kumpitak, Satapat
name: Suraprasit, Kantapon
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Maxillopoda
Sessilia
Balanidae
Megabalanus
Megabalanus tintinnabulum

description: Megabalanus cf. tintinnabulum (Linnaeus, 1758)
Figs 13 F, 17 F
 cf. Lepas tintinnabulum Linnaeus, 1758: 668. Type locality: Amboina, Indonesia [lectotype designation by Henry and McLaughlin (1986)].
 cf. Balanus (Megabalanus) tintinnabulum tintinnabulum. Pilsbry 1916: 55 – 57, pl. 10, fig. 1, 1 e. Hiro 1939: 258, fig. 7 a – b.
 cf. Balanus tintinnabulum var. tintinnabulum. Oliveira 1941: 11 – 14, text-fig. 1, pl. 2, figs. 1, 2; pl. 4, fig. 1; pl. 5, fig. 3; pl. 8, fig. 6.
 cf. Balanus tintinnabulum. Holthuis and Heerebout 1972: 24 – 31, pl. 1, fig. a – e.
 cf. Megabalanus tintinnabulum. Newman and Ross 1976: 68. Henry and McLaughlin 1986: 17 – 21, figs 1 e, 2 a, g, h, 3 a – c, 5 a – l. Jones et al. 2000: 282. Pitombo 2004: 275. Lozano-Cortés and Londoño-Cruz 2013: 466 – 467. Jones and Hosie 2016: 289 – 290. Pochai et al. 2017: 28 – 29, fig. 11
Referred material.
CUF - NKNY - O 06 - 2 (2 individuals; Figs 13 F, 17 F).
Habitat.
Attached on low exposed rocky shores in littoral areas, ship bottoms, and floating pontoons (Chan et al. 2009; Jones and Hosie 2016)
Distribution.
Cosmopolitan (Jones and Hosie 2016).
Record in Thailand.
Andaman Sea (Pochai et al. 2017). This is the first record of this species from Gulf of Thailand.
Taxonomic remarks and comparisons.
 These specimens are tentatively identified as belonging to Megabalanus tintinnabulum based on the descriptions and figures in Henry and McLaughlin (1986), Chan et al. (2009), and Pochai et al. (2017), specifically in having large cylindrical shells with smooth parietal surfaces and without spines.
description: Published as part of Jirapatrasilp, Parin, Cuny, Gilles, Kocsis, László, Sutcharit, Chirasak, Ngamnisai, Nom, Charoentitirat, Thasinee, Kumpitak, Satapat & Suraprasit, Kantapon, 2024, Mid-Holocene marine faunas from the Bangkok Clay deposits in Nakhon Nayok, the Central Plain of Thailand, pp. 1-110 in ZooKeys 1202 on pages 1-110, DOI: 10.3897/zookeys.1202.119389
Aethalops Thomas 1923
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Aethalops

description: Aethalops Thomas 1923
Aethalops Thomas 1923, Proc. Zool. Soc. Lond., 1923: 178.
Type Species: Aethalodes alecto Thomas 1923
Synonyms: Aethalodes Thomas 1923.
Species and subspecies: 2 species with 3 subspecies:
Species Aethalops aequalis G. M. Allen 1938
Species Aethalops alecto Thomas 1923
Subspecies Aethalops alecto subsp. alecto Thomas 1923
Subspecies Aethalops alecto subsp. boeadii Kitchener 1993
Subspecies Aethalops alecto subsp. ocypete Boeadi and Hill 1986
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Chiroptera - Family Pteropodidae, pp. 313-350 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 1, Baltimore :The Johns Hopkins University Press on page 314, DOI: 10.5281/zenodo.7316519
A novel approach for exposing and sharing clinical data: the Translator Integrated Clinical and Environmental Exposures Service
Creators: name: Bizon, Chris
name: Ahalt, Stanley C
name: Fecho, Karamarie
name: Pfaff, Emily
name: Xu, Hao
name: Tropsha, Alexander
name: Krishnamurthy, Ashok
name: Stillwell, Lisa
name: Champion, James
name: Peden, David B
name: Cox, Steve
Publisher: name: Oxford University Press (OUP)
Year: 2019

description: Objective

This study aimed to develop a novel, regulatory-compliant approach for openly exposing integrated clinical and environmental exposures data: the Integrated Clinical and Environmental Exposures Service (ICEES).
Materials and Methods

The driving clinical use case for research and development of ICEES was asthma, which is a common disease influenced by hundreds of genes and a plethora of environmental exposures, including exposures to airborne pollutants. We developed a pipeline for integrating clinical data on patients with asthma-like conditions with data on environmental exposures derived from multiple public data sources. The data were integrated at the patient and visit level and used to create de-identified, binned, “integrated feature tables,” which were then placed behind an OpenAPI.
Results

Our preliminary evaluation results demonstrate a relationship between exposure to high levels of particulate matter ≤2.5 µm in diameter (PM2.5) and the frequency of emergency department or inpatient visits for respiratory issues. For example, 16.73% of patients with average daily exposure to PM2.5 >9.62 µg/m3 experienced 2 or more emergency department or inpatient visits for respiratory issues in year 2010 compared with 7.93% of patients with lower exposures (n = 23 093).
Discussion

The results validated our overall approach for openly exposing and sharing integrated clinical and environmental exposures data. We plan to iteratively refine and expand ICEES by including additional years of data, feature variables, and disease cohorts.
Conclusions

We believe that ICEES will serve as a regulatory-compliant model and approach for promoting open access to and sharing of integrated clinical and environmental exposures data.