cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Circumstances and toxicology of violence-related deaths among young people who have had contact with the youth justice system: a data linkage study
Creators: name: Willoughby, Melissa
name: Young, Jesse T.
name: Hail-Jares, Katie
name: Spittal, Matthew J.
name: Borschmann, Rohan
name: Patton, George
name: Sawyer, Susan M.
name: Janca, Emilia
name: Teplin, Linda
name: Heffernan, Ed
name: Kinner, Stuart A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 2.
AK-type stability theorems on cross t-intersecting families
Creators: name: Lee, Sang June
name: Siggers, Mark
name: Tokushige, Norihide
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05D05

description: Two families, ${\mathcal A}$ and ${\mathcal B}$, of subsets of $[n]$ are cross $t$-intersecting if for every $A \in {\mathcal A}$ and $B \in {\mathcal B}$, $A$ and $B$ intersect in at least $t$ elements. For a real number $p$ and a family ${\mathcal A}$ the product measure $μ_p ({\mathcal A})$ is defined as the sum of $p^{|A|}(1-p)^{n-|A|}$ over all $A\in{\mathcal A}$. For every non-negative integer $r$, and for large enough $t$, we determine, for any $p$ satisfying $\frac r{t+2r-1}\leq p\leq\frac{r+1}{t+2r+1}$, the maximum possible value of $μ_p ({\mathcal A})μ_p ({\mathcal B})$ for cross $t$-intersecting families ${\mathcal A}$ and ${\mathcal B}$. In this paper we prove a stronger stability result which yields the above result.
description: 24 pages, 4 figures
Phase II Archaeological Investigation Curation Inventory, Ballast House, 2000.029_0006
Creators: name: System User
Publisher: name: Adelphi Research Laboratory
Year: 2000
Subjects: Blossom Point
Maryland (State / Territory)
18CH216
Ballast House
Domestic Structures
House
Domestic Structure or Architectural Complex
Ceramic
Fauna
Glass
Building Materials
Macrobotanical
Metal
Collections Management
Archaeological Overview
Heritage Management
Site Evaluation / Testing

description: Adelphi Research Laboratories curation task list for the Blossom Point Farm house Phase II archaeological investigation.
Optical absorption properties of laser-dressed matter
Creators: name: Gu, Bing
name: Franco, Ignacio
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Characterizing and controlling matter driven far from equilibrium represents a major challenge for science and technology. Here we develop a theory for the optical absorption of electronic materials driven far from equilibrium by resonant and non-resonant lasers. In it, the interaction between matter and the driving light is treated exactly through a Floquet analysis, while the effects of the probing light are captured to first order in perturbation theory. The resulting equations are reminiscent to those for equilibrium absorption but with the Floquet modes playing the role of the pristine eigenstates. The formalism is employed to characterize the optical properties of a model nanoscale semiconductor dressed by non-resonant light of intermediate intensity (non-perturbative, but non-ionizing). As shown, non-resonant light can reversibly turn this transparent semiconductor into a broadband absorber and open strong absorption/stimulated emission bands at very low frequencies (~ meV). Further, the absorption spectra of the driven material exhibit periodic features energetically spaced by the photon energy of the driving light that reflect the periodic structure of the Floquet bands. These developments offer a general approach to understand and predict the emergent optical properties of materials dressed by the electric field of light, and catalyze the design of laser-dressed materials with desired optical properties.
description: 17 pages, 8 figures
Electromagnetic dipole radiation of oscillating D-branes
Creators: name: Savvidy, G. K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: I emphasize analogy between Dp-branes in string theories and solitons in gauge theories comparing their common properties and showing differences. We will show that for certain excitations of the string/D3-brane system Neumann boundary conditions emerge from the Born-Infeld dynamics. The excitations which are coming down the string with a polarization along a direction parallel to the brane are almost completely reflected. For the wavelengths much larger than the string scale only a small fraction of the energy escapes in the form of dipole radiation. The physical interpretation is that a string attached to the 3-brane manifests itself as an electric charge, and waves on the string cause the end point of the string to freely oscillate and produce electromagnetic dipole radiation in the asymptotic outer region. The magnitude of emitted power is in fact exactly equal to the one given by Thompson formula in ordinary electrodynamics.
description: 9 pages, Latex, espcrc2.sty, psfig.sty; Based on talk given at QG99, Third Meeting on Constrained Dynamics and Quantum Gravity, Villasimius,(Sardinia, Italy), September 13-17, 1999
Site Information, Cedar Point, 2000.027_0254
Creators: name: Roudebush, Ray
name: Bertels, Henry J.
name: Steponaitis, Laurie C.
name: Crouse, Richard
name: Murtland, Douglas
name: Mastrogianis, George H.
name: Clark, Wayne E.
name: Couchenour, Barbara
name: Bastian, Tyler
Year: 1980
Subjects: Mathias Point
Cedar Point Neck
Goose Creek
Nanjemoy Creek
Pope's Creek
Blossom Point
Maryland (State / Territory)
Charles (County)
Port Tobacco River
18CH216
18CH109
18CH80
Ballast House
18CH76
Domestic Structures
House
Domestic Structure or Architectural Complex
Shell
Ceramic
Chipped Stone
Fauna
Flora
Collections Management
Collections Research
Records Search / Inventory Checking
Heritage Management

description: Background information for Cedar Point, Nanjamoy Creek, and Port Tobacco areas from the mid to late 1800's. Includes letters about the Ballast House and maps of Cedar Point. In addition, there also includes a 106 Case Report and Mitigation Plan, for Ballast House, Blossom Point Testing Facility, Charles County, Maryland.
Phase I Archaeological Investigation Curation Inventory, Ballast House, 2000.029_0005
Creators: name: System User
Publisher: name: Adelphi Research Laboratory
Year: 1990
Subjects: Blossom Point
Maryland (State / Territory)
18CH216
Ballast House
House
Shell
Ceramic
Chipped Stone
Rubber
Fauna
Glass
Plastic
Building Materials
Quartzite
Metal
Weapons Shell Casings
Collections Management
Archaeological Overview
Heritage Management

description: This is the Adelphi Research Laboratories curation inventory list for the phase I investigation completed at the Blossom Point Farmhouse, site 18CH216.
Back Gate Guard Station for the Adelphi Laboratory Center, Adelphi, Maryland, Project Report
Creators: name: System User
Year: 2018
Subjects: Charles County (County)
Nanjemoy Creek
Potomac River
Maryland (State / Territory)
Port Tobacco River
Blossom Point, MD
Cedar Neck Point
18CH216
Ballast House
Collections Management
Heritage Management

description: The project proposes the relocation of an existing Guard House which has been removed from its existing site due to construction activity and the acquisition of additional land from the Naval Surface Warfare Center. In addition to the Guard House an 8 foot high double swing gate will be placed across Floral Drive. In addition, an 8 foot high metal chain link fence will be installed perpendicular to the existing fence along Floral Drive and across to the perimeter fence, located in back of The Cherry Mill Road community. The gate and fence will be secured with barbed wire. The Guard Station will be supported with electricity and communications. Electricity will be drawn from the 600 Area to provide heating and lighting.
Picobia galerida Skoracki 2011
Creators: name: LIU, DONG
name: YI, TIAN-CI
name: XU, YUN
name: ZHANG, ZHI-QIANG
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Syringophilidae
Picobia
Picobia galerida

description: Picobia galerida Skoracki, 2011: 367
— Holotype female (AMU–SYR.269), from Galerida cristata (Linnaeus) (Passeriformes: Alaudidae), near Swinoujscie, Zachodniopomorskie, Poland.
description: Published as part of LIU, DONG, YI, TIAN-CI, XU, YUN & ZHANG, ZHI-QIANG, 2013, Hotspots of new species discovery: new mite species described during 2007 to 2012, pp. 1-102 in Zootaxa 3663 (1) on page 64, DOI: 10.11646/zootaxa.3663.1.1, http://zenodo.org/record/5630595
Adelphi Project Collection Notes
Creators: name: Veterans Curation Program
Year: 2017
Subjects: Adelphi, MD
Maryland (State / Territory)
Collections Management
Heritage Management

description: This document contains information on the resources contained in the Adelphi, Maryland archaeological investigations including; General Adelphi Project Collections notes, Maryland Archaeological Conservation (MAC) Lab Collection, and Adelphi Lab Collections.
Additional file 2: of Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study
Creators: name: Candlish, Jane
name: M. Teare
name: Munyaradzi Dimairo
name: Flight, Laura
name: Mandefield, Laura
name: Walters, Stephen
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional details including: model fitting code for Stata, R, and SAS for the homoscedastic and heteroscedastic partially nested models; performance measures; and results tables. (DOCX 189 kb)
Epigenetic Regulation Of Gene Expression Domains In Pluripotent Stem Cells
Creators: name: Nikic, Svetlana
Publisher: name: Imperial College London
Year: 2009

description: Transcriptional and histone modification profiles were analysed in detail across several regions of the mouse genome in order to examine how tissue-specificity is determined at early stages of development and how it is maintained during cell commitment. The analysis was mainly focused on a 2 Mb gene-dense region containing 68 known closely situated genes, having very diverse expression patterns. Transcriptional profiling of this region showed that clustered tissue-restricted and housekeeping genes are associated with clearly defined monovalent or bivalent epigenetic domains. In ES cells, the actively transcribed housekeeping genes were enriched for histone H3K4me1, H3K4me2, H3K4me3, H3K9ac and binding of Pol II. Most of the silent tissue-restricted genes were marked by bivalent domains and had background levels of Pol II. In few cases, substantial levels of Pol II were found at inactive genes situated close to housekeeping genes, suggesting that transcriptional read-through could be occurring at these genes in ES cells. Epigenetic profiling of the gene-dense region in LPS-activated B cells showed that B cells have a very similar histone modification profile to ES cells. Specifically, the analysis showed that bivalent domains which were thought to be a defining characteristic of pluripotent stem cells are equally prevalent in B cells, suggesting that the epigenetic marking of silent genes is quite similar in these two very different cell types. Analysis of a large gene-poor region containing four genes encoding GABAA neurotransmitter receptor subunits showed that the this locus acquires a large bivalent domain of approximately 1.3 Mb following differentiation of ES cells into NS cells and astrocytes. The results obtained in this study demonstrate the complex and diverse nature of histone modifications at tissue-restricted genes and suggest that trans-acting factors are responsible for generating highly specific combinations of histone modifications at each individual gene at different stages of cell differentiation.
A Submillimeter Perspective on the GOODS Fields (SUPER GOODS). III. A Large Sample of ALMA Sources in the GOODS-S
Creators: name: Cowie, Lennox L.
name: Gonzalez-Lopez, Jorge
name: Barger, Amy J.
name: Bauer, Franz E.
name: Hsu, Li-Yen
name: Wang, Wei-Hao
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyze the >4-sigma sources in the most sensitive 100 arcmin^2 area (rms <0.56 mJy) of a SCUBA-2 850 micron survey of the GOODS-S and present the 75 band 7 ALMA sources (>4.5-sigma) obtained from high-resolution interferometric follow-up observations. The SCUBA-2---and hence ALMA---samples should be complete to 2.25 mJy. Of the 53 SCUBA-2 sources in this complete sample, only five have no ALMA detections, while 13% (68% confidence range 7-19%) have multiple ALMA counterparts. Color-based high-redshift dusty galaxy selection techniques find at most 55% of the total ALMA sample. In addition to using literature spectroscopic and optical/NIR photometric redshifts, we estimate FIR photometric redshifts based on an Arp 220 template. We identify seven z>4 candidates. We see the expected decline with redshift of the 4.5 micron and 24 micron to 850 micron flux ratios, confirming these as good diagnostics of z>4 candidates. We visually classify 52 ALMA sources, finding 44% (68% confidence range 35-53%) to be apparent mergers. We calculate rest-frame 2-8 keV and 8-28 keV luminosities using the 7 Ms Chandra X-ray image. Nearly all of the ALMA sources detected at 0.5-2 keV are consistent with a known X-ray luminosity to 850 micron flux relation for star-forming galaxies, while most of those detected at 2-7 keV are moderate luminosity AGNs that lie just above the 2-7 keV detection threshold. The latter largely have substantial obscurations of log N_H = 23-24 cm^-2, but two of the high-redshift candidates may even be Compton thick.
description: 44 pages, 35 figures. Submitted to ApJ
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00285
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00285, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00285, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Letter from Maryland Historical Trust to US Army Research Laboratory, Adelphi Phase I/II Second Draft
Creators: name: J. Rodney Little
Publisher: name: Maryland Historical Trust
Year: 1995
Subjects: Adelphi, MD
Maryland (State / Territory)
18PR465
18PR466
Ceramic
Coins
Metal
Collections Management
Heritage Management

description: A letter from the Maryland Historical Trust Office to the Chief of Division of Public Works, US Army Research Laboratory in regards to the second draft of the Phase I/II Archaeology, Site W - US Naval Surface Warfare Center, in Prince George's County, Maryland.
Additional file 9 of Overexpression of miR-340 inhibits cell proliferation and induces apoptosis of human bladder cancer via targeting Glut-1
Creators: name: Xu, Gang
name: Pan, Shouhua
name: Zhu, Zhirong
name: Li, Junlong
Publisher: name: figshare
Year: 2021
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 9. Fig. S9: p-AKT.
Picobia glossopsitta Skoracki, Glowska & Sikora 2008
Creators: name: LIU, DONG
name: YI, TIAN-CI
name: XU, YUN
name: ZHANG, ZHI-QIANG
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Syringophilidae
Picobia
Picobia glossopsitta

description: Picobia glossopsitta Skoracki, Glowska & Sikora, 2008: 67
— Holotype female (AMU, Syr. 139), from the Purplecrowned Lorikeet Glossopsitta porphyrocephala (Dietrichsen) (Psittaciformes: Psittacidae), New Holland, Australia.
description: Published as part of LIU, DONG, YI, TIAN-CI, XU, YUN & ZHANG, ZHI-QIANG, 2013, Hotspots of new species discovery: new mite species described during 2007 to 2012, pp. 1-102 in Zootaxa 3663 (1) on page 64, DOI: 10.11646/zootaxa.3663.1.1, http://zenodo.org/record/5630595
Development of an Ex Vivo Three Dimensional (3-D) Model of Acute Myeloid Leukaemia (AML)
Creators: name: Mortera Blanco, Teresa
Publisher: name: Imperial College London
Year: 2008

description: Acute Myeloid Leukaemia (AML) is a cancer of hematopoietic stem cells that develops in the three-dimensional (3-D) niches provided by the bone marrow microenvironment in vivo. The study of AML has been hampered by the lack of appropriate ex vivo models, which can mimic this microenvironment. It was hypothesised that the fabrication of scaffolds for the biomimetic growth of leukemic cells ex vivo could facilitate the study of the disease in its native 3-D niche. The growth of different leukemic cell lines was first evaluated, namely K- 562, HL-60 and Kasumi-6 on highly porous scaffolds fabricated from biodegradable and non-biodegradable polymeric materials: poly (L-lactic-co-glycolic acid) (PLGA), polyurethane (PU), poly (methyl-methacrylate) (PMMA), poly (D, L-lactade) (PDLLA), poly (caprolactone) (PCL), and polystyrene (PS). These results were compared with two commercially available scaffolds from BD™ Biosciences. Overall, out of all the scaffolds, PLGA and PU displayed the best seeding efficiency and leukemic cellular growth, assessed by MTS assay, scanning electron microscopy and immunohistochemistry. In order to improve the ex vivo 3-D leukemic cell culture, PLGA and PU scaffolds were coated with bone marrow extracellular matrix (ECM) proteins, collagen (62.5 or 125 μg/ml) and fibronectin (25 or 50 μg/ml) and a combination of both proteins: collagen + fibronectin (62.5 + 25 μg/ml) respectively. Once the abnormal hematopoietic 3-D model was established, a new model to culture normal hematopoietic cord blood mononuclear cells was studied and compared. All 3 leukemic cell lines and cord blood cells grew better in PU scaffolds coated with collagen type I using the low concentration and sustained growth in the absence of exogenous cytokines. As a result, it was concluded that PU-collagen scaffold could provide a practical model with which to study the biology and treatment of primary AML in an ex vivo mimicry without the use of animal models.
Damping of giant resonances in asymmetric nuclear matter
Creators: name: Morawetz, K.
name: Fuhrmann, U.
name: Walke, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The giant collective modes in asymmetric nuclear matter are investigated within a dynamic relaxation time approximation. We derive a coupled dispersion relation and show that two sources of coupling appear: (i) a coupling of isoscalar and isovector modes due to different mean-fields acting and (ii) an explicit new coupling in asymmetric matter due to collisional interaction. We show that the latter one is responsible for a new mode arising besides isovector and isoscalar modes.
description: Varenna conference proceedings
Local migration quantification method for scratch assays
Creators: name: Bobadilla, Ana Victoria Ponce
name: Arévalo, Jazmine
name: Sarró, Eduard
name: Byrne, Helen
name: Maini, Philip K
name: Carraro, Thomas
name: Balocco, Simone
name: Meseguer, Anna
name: Alarcón, Tomás
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: Motivation: The scratch assay is a standard experimental protocol used to characterize cell migration. It can be used to identify genes that regulate migration and evaluate the efficacy of potential drugs that inhibit cancer invasion. In these experiments, a scratch is made on a cell monolayer and recolonisation of the scratched region is imaged to quantify cell migration rates. A drawback of this methodology is the lack of its reproducibility resulting in irregular cell-free areas with crooked leading edges. Existing quantification methods deal poorly with such resulting irregularities present in the data. Results: We introduce a new quantification method that can analyse low quality experimental data. By considering in-silico and in-vitro data, we show that the method provides a more accurate statistical classification of the migration rates than two established quantification methods. The application of this method will enable the quantification of migration rates of scratch assay data previously unsuitable for analysis. Availability and Implementation: The source code and the implementation of the algorithm as a GUI along with an example dataset and user instructions, are available in https://bitbucket.org/anavictoria-ponce/local_migration_quantification_scratch_assays/src/master/. The datasets are available in https://ganymed.math.uni-heidelberg.de/~victoria/publications.shtml.
Characterisation of T cell surface phenotype and effector function in a surrogate model of rheumatoid arthritis
Creators: name: Smith, Nicola Marianne Godwin
Publisher: name: Imperial College London
Year: 2009

description: TNFα plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), however the mechanisms underlying its dysregulation are not completely understood. TNFα production by macrophages is dependent on their contact with synovial T cells. In an in vitro model of RA, peripheral blood lymphocytes stimulated with a cocktail of cytokines mimic this RA T cell effector function. This thesis defines and characterises the effector population of cytokine-activated human T cells through two different approaches. Studies presented here show that within a population of cytokine-activated T cells, CD4+CD45RO+CCR7- cells induce the highest levels of TNFα when co-cultured with monocytes. Cytokine-activated CD4+ memory T cells phenotypically and functionally resemble lymphocytes isolated from RA synovial tissue. The cytokine cocktail induces proliferation and differentiation of peripheral blood T cells into highly potent effectors. These cells upregulate specific activation markers, adhesion molecules and chemokine receptors; such as CD25, CD69, CD62L, VLA-4, LFA-1 and CXCR4 which directly or indirectly, contribute to the induction of TNFα. By defining the phenotype of the lymphocytes most capable of inducing TNFα in our model, I isolated a population of T cells on which to focus my studies. The molecular nature of contact-dependent monocyte activation by cytokineactivated T cells was further investigated through proteomic profiling of the T cell surface. Plasma membrane protein-enriched samples were resolved in one- and two-dimensions. Subsequent mass spectrometry identified two molecules of interest. CD97 was found to be highly expressed by cytokine-activated CD4+ memory T cells, and contributed to both the induction of monocyte TNFα and spontaneous TNFα release from rheumatoid synovial tissue. Expression of CD81 and other tetraspanin family members increased on cytokine activation and was observed in synovial tissue. The results presented in this thesis provide further insight into the contribution of T cells in RA.
Additional file 1 of Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study
Creators: name: Xin, Junyi
name: Jiang, Xia
name: Ben, Shuai
name: Yuan, Qianyu
name: Su, Li
name: Zhang, Zhengdong
name: Christiani, David C.
name: Du, Mulong
name: Wang, Meilin
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Summary of cancer-specific GWAS data included in Mendelian randomization (MR) analysis. Table S2. ICD-10 diagnosis codes for ten cancers in the UK Biobank cohort. Table S3. Characteristics of circulating vitamin E-associated instrumental variants (IVs). Table S4. Associations of circulating vitamin E instrumental variants (IVs) with multiple cancer risk in cancer-specific GWAS. Table S5. Mendelian randomization (MR) analysis for the associations of circulating vitamin E with cancer risk in cancer-specific GWAS. Table S6. Leave-one-out analysis for the associations between circulating vitamin E and cancer risk in cancer-specific GWAS. Table S7. Summary of 24 traits related to circulating vitamin E associated SNPs. Table S8. Sensitivity analysis of genetic risk score (GRS) analysis for the associations of vitamin E with cancer risk in the UK Biobank cohort. Table S9. Summary of dietary vitamin E intake associated SNPs derived from the UK Biobank cohort. Table S10. Functional annotation of dietary vitamin E intake associated SNPs. Table S11. Summary of dietary vitamin E associated variants in the UK Biobank cohort. Figure S1. Conceptual framework of Mendelian randomization (MR) analysis in this study. Figure S2. The effect of each variant on circulating vitamin E (exposure) and cancer risk (outcome) in cancer-specific GWAS. Figure S3. Manhattan and quantile-quantile (QQ) plots for the dietary vitamin E intake-related GWASs in the UK Biobank cohort.
Aziridine–Metathesis based Approaches to Alkaloid Synthesis
Creators: name: Lu, Pengfei
Publisher: name: Imperial College London
Year: 2009

description: The aim of the project is to synthesise (–)-morphine utilising aziridine and metathesis chemistry. The thesis is divided into three chapters. Chapter 1 provides brief reviews on the subjects of total synthesis of morphine; ringrearrangement metathesis (RRM) and regioselective ring-opening of aziridines. Chapter 2 focuses on the research findings in the past three years. Two routes, A and B, were investigated in attempts to synthesise morphine (Scheme 1). In route A, sulfonyl cyclopentene II was prepared from ring-closing metathesis of a diene precursor, which was synthesised from lithiated cinnamylsulfone and butadiene monoxide. Subsequently, RRM reactions of several α-SO2Ph allyl derivatives of II were investigated and some interesting results were obtained. The synthesis of 2,3-trans vinylaziridine III was achieved in seven steps beginning with a Grignard reaction of (4- methoxyphenyl)magnesium bromide with butadiene monoxide. Subsequently, some highly regioselective ring-opening reactions of III with sulfur-stabilised anionic nucleophiles were achieved. However, in an attempt to synthesise compound I from II and III, no reaction was observed. This led to the investigation of route B, in which five methods for the synthesis of compound IV were investigated. The practical approach deployed a novel Al-mediated substitution of the 4-tosyl group of the tosyl tetrahydropyridine counterpart of IV, prepared from V and III, with a phenylthio group. Chapter 3 provides the experimental details and characterisation data.
The MicroTCA fast control board for generic control and data acquisition applications in HEP experiments
Creators: name: Zhang, Jie
name: Li, Hangxu
name: Gu, Jingzi
name: Jiang, Xiaoshan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: To provide the generic clock, trigger and control function and fulfill the data transmission performance requirement in high energy physics (HEP) experiments, a MicroTCA Fast Control board (uFC) was developed based on the Advanced Mezzanine Card (AMC) specification. Built around the Xilinx Kintex-7 FPGA, the uFC provides users with a platform with data memory, reference clock, trigger and SFP+ (Small Form-factor Pluggable) connections that are required in general experiment. In addition, it has access to two on-board FPGA Mezzanine Card (FMC) sockets with a large array of configurable I/O and high-speed links up to 10 Gbps. This paper presents test results from the first set of pre-production prototypes and reports on the application in High Energy Photon Source in China.
description: 5 pages, 8 figures, proceedings of 21st IEEE Real Time Conference Colonial Williamsburg 9-15 June 2018
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis
Creators: name: Wang, Hongfeng
name: Wang, Nana
name: Xu, Delai
name: Ma, Qilian
name: Chen, Yang
name: Xu, Shiqiang
name: Xia, Qin
name: Zhang, Yan
name: Prehn, Jochen H. M.
name: Wang, Guanghui
name: Ying, Zheng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Significant evidences indicate that reactive oxygen species (ROS) can induce macroautophagy/autophagy under both physiological and pathological conditions. Although the relationship between ROS and autophagy regulation has been well studied, the basic mechanism by which ROS affects autophagy and the biological role of this regulation are still not fully understood. In the present study we show that multiple MiT-TFE transcription factors including TFEB, TFE3 and MITF, which are master regulators of autophagy and lysosomal biogenesis, can be activated upon direct cysteine oxidation by ROS. Oxidation promotes the nuclear translocation of these MiT-TFE transcription factors by inhibiting the association of them with RRAG GTPases, which in turn leads to enhanced global gene expression level in autophagy-lysosome system. Our study highlights the role of oxidation of MiT-TFE transcription factors in ROS-linked autophagy, and provides novel mechanism that MiT-TFE transcription factors-mediated transcriptional control of autophagy may govern cell homeostasis in response to oxidative stress, a biological process tightly linked to human diseases including neurodegenerative diseases and cancer. Bafi A1: bafilomycin A1; EBSS: Earle’s balanced salt solution; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTORC1: mechanistic target of rapamycin kinase complex 1; ROS: reactive oxygen species; RPS6KB/p70S6K: ribosomal protein S6 kinase B; TFEB: transcription factor EB; WT: wild type.
Electoral systems, ehtnic heterogeneity and party system fragmentation
Creators: name: Lublin, David
Publisher: name: American University
Year: 2023

description: Taking into proper account the geographic distribution of ethnic groups and the operation of electoral systems within individual countries reveals that the impact of ethnic diversity and electoral systems on the number of parties has been underestimated. Contrary to earlier findings, this study reveals that ethnic diversity spurs party proliferation in countries with both majoritarian and proportional electoral systems, though the effect is stronger in the latter. The insights gained here provide a theoretically derived measure of ethnic diversity that is useful for estimating its effect on specifically political phenomena and generating an improved holistic measure of the impact of electoral systems. More crucially, the results indicate that electoral system designers have a greater capacity to structure electoral outcomes. The results rely on multivariate models created using a new database with election results from 1990 through 2011 in sixty-five free democracies.
Rapid counter-diabatic sweeps in lattice gauge adiabatic quantum computing
Creators: name: Hartmann, Andreas
name: Lechner, Wolfgang
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We present a coherent counter-diabatic quantum protocol to prepare ground states in the lattice gauge mapping of all-to-all Ising models (LHZ) with considerably enhanced final ground state fidelity compared to a quantum annealing protocol. We make use of a variational method to find approximate counter-diabatic Hamiltonians that has recently been introduced by Sels and Polkovnikov [Proc. Natl. Acad. Sci. 114, 3909 (2017)]. The resulting additional terms in our protocol are time-dependent local on-site y-magnetic fields. These additional Hamiltonian terms do not increase the minimal energy gap, but instead rely on coherent phase maximization. A single free parameter is introduced which is optimized via classical updates. The protocol consists only of local and nearest-neighbor terms which makes it attractive for implementations in near term experiments.
description: 11 pages, 9 figures
Extended Gauge Invariance in Geometrical Particle Models and the Geometry of W-Symmetry
Creators: name: Ramos, E.
name: Roca, J.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We prove that particle models whose action is given by the integrated $n$-th curvature function over the world line possess $n+1$ gauge invariances. A geometrical characterization of these symmetries is obtained via Frenet equations by rephrasing the $n$-th curvature model in $\reals^d$ in terms of a standard relativistic particle in $S^{d-n}$. We ``prove by example'' that the algebra of these infinitesimal gauge invariances is nothing but $\W_{n+2}$, thus providing a geometrical picture of the $\W$-symmetry for these models. As a spin-off of our approach we give a new global invariant for four-dimensional curves subject to a curvature constraint.
description: plain TeX (macros included). Slightly modified version published in Nuc. Phys. B
Review of Draft Report, "Phase II Cultural Resource Investigations at Locus I (18MO396) , Army Research Laboratory Adelphi Laboratory Center, Montgomery and Prince Georges County, Maryland"
Creators: name: Fickel, William
Publisher: name: US Army Corps of Engineers, Fort Worth District
Year: 1995
Subjects: Adelphi, MD
Maryland (State / Territory)
18MO396
Collections Management
Heritage Management

description: This is a review of the draft report submitted to the US Army Research Laboratory and the US Army Corps of Engineers, Baltimore District which was prepared by Hunter Research, Inc. In general, the report appears to satisfy the requirements for the Phase II testing of site 18MO396. However, this office still disagrees with the contractor’s conclusions regarding the National Register of Historic Places (NR) eligibility of the site under Criterion D (36 CFR § 60.4). The report does not, in our opinion, justify the recommendations for further work at site 18MO396. The contractor states the principal basis for their recommendations as the presence of two temporally-distinct horizontal concentrations (two diagnostics) of prehistoric material and the discovery of a possible Paleoindian fluted point fragment.
Additional file 1: of Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study
Creators: name: Candlish, Jane
name: M. Teare
name: Munyaradzi Dimairo
name: Flight, Laura
name: Mandefield, Laura
name: Walters, Stephen
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Example Stata code used to run the simulations described in the manuscript text. (DOCX 16 kb)
Letter from Harry Diamond Laboratories to US Army Materiel Development and Readiness Command, Ballast House Protection at Blossom Point
Creators: name: Chapman, Glenn P.
Publisher: name: US Army Material Development and Readiness Command
Year: 1979
Subjects: Charles County (County)
Nanjemoy Creek
Potomac River
Maryland (State / Territory)
Port Tobacco River
Blossom Point, MD
Cedar Neck Point
18CH216
Ballast House
Collections Management
Heritage Management

description: Letter from Harry Diamond Laboratories to US Army Materiel Development and Readiness Command, in regards to the archaeological surveys for the Ballast House Protection at Blossom Point.
Regulation of the IGK Locus and B Cell Development
Creators: name: Taylor, Benjamin James Miles Taylor
Publisher: name: Imperial College London
Year: 2008

description: Allelic exclusion coupled to lineage and stage specific regulation ensure the Igκ locus undergoes RAG mediated V-J recombination only at the small pre-BII stage of lymphocyte development. These mechanisms also ensure the final antigen receptor is monospecific and allow self-specific receptors to be recognised and altered at later stages of development. Allelic exclusion is controlled by mechanism involving either epigenetic based allele selection early in development or probabilistic activation of a single allele at the small pre-BII stage. Current models favour the probabilistic model based on an elegant GFP reporter system. We present a reappraisal of this models based on an absence of the originally detected probabilistic activation. We find the absence to be explained in part by an aberrant splice event generated by developmentally regulated Igκ germline promoter usage. The activity of the promoter was investigated using in-vitro models of critical events during the B cell development but their role remains elusive. Intense investigation for the last 20 years has determined that chromatic regulation underpins the stage and lineage specification of rearrangement. The protein factors responsible for this regulation remain unknown. Using transgene reporters of cis-acting sequences and in-vitro model systems of B cell development, we find an involvement for members of the zinc finger family of Ikaros transcription factors, IRF4 and LEF1. We determined a bipartite role for Ikaros whereby its activity could both suppress rearrangement prior to pre-BCR signalling and promote rearrangement thereafter, possibly through an IRF4 based mechanism. Finally we present evidence for a role for Ikaros protein in later stages of B cell development. We find modulation of Ikaros activity directly influences the ability of cells to differentiate to the plasma cell fate. We used a transgenic model to allow genome-wide mapping of the transcriptional events regulated by Ikaros and find multiple small modulations of factors and pathways.
Critical density of topological defects upon a continuous phase transition
Creators: name: Sorokin, A. O.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using extensive Monte Carlo simulations, we test the hypothesis that the density of corresponding topological defects has an universal value at the temperature of a continuous phase transition. We consider several simple two-dimensional models where domain walls, vortices, so-called $\mathbb{Z}_2$ vortices or their combinations are presented. These topological defects are relevant correspondingly to an Ising second-order phase transition, a Berezinskii-Kosterlitz Thouless transition and an explicit crossover. We compare results for square and triangular lattices as well as for the complicated situation when two types of defects are presented and two transitions occur separated in temperature. All considered cases demonstrate consentient results confirming the hypothesis.
description: 25 pages, 26 figures, 3 tables
'Mafias' in the waterscape : Urban informality and everyday public authority in Bangalore
Creators: name: Ranganathan, Malini
Publisher: name: American University
Year: 2023

description: This article investigates the phenomenon of Bangaloreʼs urban 'water mafias', operators who extract and deliver groundwater to scores of informal residential areas in Indian cities. The term 'mafia' here is treated as a semantic area of situated meanings and cultural interpretations that needs to be historicised and prised open in order to better understand how the urban waterscape is produced and inhabited. It situates the provenance and workings of mafias within wider debates on urban informality, state formation, and urban infrastructure and space. Rather than seeing mafias as filling a gap where government water supply has failed, as mainstream narratives suggest, the paper argues that mafias must be seen as formative of the post-colonial state. It further suggests that the specific form of public authority exercised by water mafias explains the production of informality in Bangaloreʼs waterscape. Based on ethnographic research in 2007-2009, the paper characterises the everyday authority wielded by mafias along three main registers: (i) the ability of mafias to make and break discursive and material boundaries between the formal and informal, public and private, and state and society, (ii) the varied nature of mafiasʼ political practices, ranging from exploitation to electoral lobbying to social protection to the provision of welfare, and iii) mafiasʼ complicity in both water and land regimes in a neo-liberalised urban political economy.
On the multilevel internal structure of the asymptotic distribution of resonances
Creators: name: Albeverio, Sergio
name: Karabash, Illya M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 35B34, 35P20, 35J10, 35P25, 81Q37, 81Q35, 78A45, 81Q80, 70J10, 05C90

description: We prove that the asymptotic distribution of resonances has a multilevel internal structure for the following classes of Hamiltonians H: Schrödinger operators with point interactions in $\mathbb{R}^3$, quantum graphs, and 1-D photonic crystals. In the case of $N \ge 2$ point interactions, the set of resonances $Σ(H)$ essentially consists of a finite number of sequences with logarithmic asymptotics. We show how the leading parameters $μ$ of these sequences are connected with the geometry of the set $Y=\{y_j\}_{j=1}^N$ of interaction centers $y_j \in \mathbb{R}^3$. The minimal parameter $μ^{min}$ corresponds to the sequences with `more narrow' and so more observable resonances. The asymptotic density of such narrow resonances is described by the multiplicity of $μ^{\min}$, which occurs to be connected with the symmetries of Y and naturally introduces a finite number of classes of configurations of $Y$. In the case of quantum graphs and 1-D photonic crystals, the decomposition of $Σ(H)$ into a finite number of asymptotic sequences is proved under additional commensurability conditions. To address the case of a general quantum graph, we introduce families of special counting and asymptotic density functions for two types of curved complex strips. The obtained results and effects are compared with those of obstacle scattering.
description: 32 pages. Typos are corrected. Minor inaccuracies are corrected in condition (C1) of Section 4.2 and in Example 4.7. References are updated
Letter from Harry Diamond Laboratories to Interagency Archeological Services-Atlanta, Memorandum of Agreement
Creators: name: Chapman, Glenn P.
Publisher: name: Harry Diamond Laboratories
Year: 1979
Subjects: Charles County (County)
Nanjemoy Creek
Potomac River
Maryland (State / Territory)
Port Tobacco River
Blossom Point, MD
Cedar Neck Point
18CH216
Ballast House
Domestic Structures
House
Domestic Structure or Architectural Complex
Collections Management
Heritage Management

description: Letter from Harry Diamond Laboratories to Interagency Archeological Services-Atlanta, in regards to the Memorandum of Request for Determination of Eligibility for Inclusion in the National Register. Enclosed is a DA Form 2496, Disposition Form.
Relativistic mean-field description of the dynamics of giant resonances
Creators: name: Vretenar, D.
name: Ring, P.
name: Lalazissis, G. A.
name: Paar, N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The relativistic mean-field theory provides a framework in which the nuclear many-body problem is described as a self-consistent system of nucleons and mesons. In the mean-field approximation, the self-consistent time evolution of the nuclear system describes the dynamics of collective motion: nuclear compressibility from monopole resonances, regular and chaotic dynamics of isoscalar and isovector collective vibrations.
description: LaTeX, 10 pages, 5 figures, Invited Talk, Topical Conference on Giant resonances, Varenna, May 1998, to be published in Nucl. Phys. A
Human proteomic profiles in latent and active tuberculosis
Creators: name: Sandhu, Gurjinder Singh
Publisher: name: Imperial College London
Year: 2010

description: Distinguishing patients with active tuberculosis (TB) from those with latent TB is an important clinical problem. The SELDI-TOF MS (Surface Enhanced Laser Desorption Ionisation – Time of Flight Mass Spectrometry) platform allows for high throughput detection of multiple proteins in biological fluids. Proteomic patterns reflecting host-pathogen interaction can be used as a tool to aid our understanding of the Natural History of Tuberculosis. Methods: Plasma samples were collected prospectively in a shanty town in Lima, Peru. Latent and active TB status was defined using the Tuberculin Skin Test (TST), Quantiferon (QFN) assay and TB culture. Crude plasma and fractionated plasma samples were analysed on weak cationic CM10 chip surfaces using a Biomek 3000 Laboratory Automation Workstation. Spectra were generated using a ProteinChip System 4000 Mass spectrometer. Data was analysed using a Support Vector Machine. Results: Samples were collected from 154 patients with active TB, 112 patients with respiratory symptoms suggestive of TB and 151 healthy controls. Multiple peaks differed significantly between active TB patients and unhealthy controls. Trained optimal classifiers discriminate between: i) active TB and unhealthy controls with 84% accuracy (87% sensitivity, 79% specificity) in crude plasma and up to 89% accuracy (90% sensitivity, 88% specificity) in fractionated plasma ii) active TB and latent TB with 89% accuracy (90% sensitivity, 89% specificity) iii) latent TB and no TB in healthy controls with 77% accuracy (67% sensitivity, 84% specificity). Conclusions: SELDI-TOF MS proteomic profiles in combination with trained optimal classifiers accurately discriminate active TB from other respiratory disorders. The classifier for latent TB was not as accurate, but active TB could be discriminated from latent TB.