cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality
Creators: name: Thomas, Jacob
name: Sen, Buer
name: Xie, Zhihui
name: Styner, Maya
name: Case, Natasha
name: Rubin, Janet
name: Rowe, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Exercise-generated signals are pro-osteogenic and anti-adipogenic within the marrow. In vitro studies indicate that mechanical signals directly block adipogenic differentiation through activation of β-catenin and by limiting PPARγ2 expression. Whether mechanically generated β-catenin can inhibit adipogenesis during PPARγ transactivation is unknown. We evaluated the ability of mechanical signals to limit adipogenesis in marrow derived mesenchymal stem cells (mdMSC) distal to activation of PPARγ. First, we established that mdMSC attained an adipogenic phenotype within 2-4 days in the presence of rosiglitazone (1-25 μM) and that β-catenin activation via GSK3β inhibition interfered with this process. Similarly, mechanical strain (3600 cycles, 2% strain daily) inhibited adipogenesis at 3 days, preventing rosiglitazone-induced PPARγ upregulation as well as aP2 and adiponectin protein expression. To assess whether a reduction in PPARγ expression was necessary for anti-adipogenic action, PPARγ2 was overexpressed: both mechanical strain and GSK3β inhibition prevented expression of aP2 and adiponectin proteins despite abundant PPARγ2 and its ligand. To understand the fate of single cells experiencing mechanical strain we generated mdMSC from aP2-GFP reporter expressing mice. Rosiglitazone treatment for 3 days induced GFP expression in more than 80% of cells. Sorting by GFP expression revealed that the highest 20% of aP2-GFP expressing cells was responsible for the majority of adipogenic protein expression. This highly expressing GFP fraction had a reduced ability to respond to an osteogenic stimulus: BMP-2 treatment increased osterix by 12-fold in contrast to the 42-fold increase in osterix expression that resulted from BMP-2 treatment of the bottom 75% of GFP expressing cells. This suggested that highly expressing aP2-GFP cells represented more terminally differentiated adipocytes, with reduced multipotentiality. Application of mechanical strain to aP2-GFP mdMSC treated with rosiglitazone caused a two-fold decrease in the size of the upper cell fraction, suggesting that mechanical strain preserved MSC in a multipotent state. Our data show that mechanical strain restricts adipogenesis both by limiting PPARγ2 expression and by preventing PPARγ action, protecting the potential of MSC to enter other lineages.
Spin-Phonon Coupling and High-Temperature Phase Transition in Multiferroic Material YMnO3
Creators: name: Gupta, Mayanak Kumar
name: Mittal, Ranjan
name: Zbiri, Mohamed
name: Sharma, Neetika
name: Rols, Stephane
name: Schober, Helmut
name: Chaplot, Samrath Lal
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have carried out temperature-dependent inelastic neutron scattering measurements of YMnO3 over the temperature range 50 - 1303 K, covering both the antiferromagnetic to paramagnetic transition (70 K), as well as the ferroelectric to paraelectric transition (1258 K). Measurements are accompanied by first principles calculations of phonon spectra for the sake of interpretation and analysis of the measured phonon spectra in the room temperature ferroelectric (P63cm) and high temperature paraelectric (P63/mmc) hexagonal phases of YMnO3. The comparison of the experimental and first-principles calculated phonon spectra highlight unambiguously a spin-phonon coupling character in YMnO3. This is further supported by the pronounced differences in the magnetic and non-magnetic phonon calculations. The calculated atomistic partial phonon contributions of the Y and Mn atoms are not affected by inclusion of magnetic interactions, whereas the dynamical contribution of the O atoms is found tochange. This highlights the role of the super-exchange interactions between the magnetic Mn cations, mediated by O bridges. Phonon dispersion relations have also been calculated, in the entire Brillouin zone, for both the hexagonal phases. In the high-temperature phase, unstable phonon mode at the K point is highlighted. The displacement pattern at the K-point indicates that the freezing of this mode along with the stable mode at the Γ-point may lead to a stabilization of the low-temperature (P63cm) phase, and inducing ferroelectricity. Further, we have also estimated the mode Grüneisen parameter and volume thermal expansion behavior. The latter is found to agree with the available experimental data.
description: 23 pages, 8 Figures
„Bridging the gap“ – Zur Verringerung der Kluft zwischen allgemeinen Lehr-Lernmodellen und konkreter Unterrichtsgestaltung am Beispiel der Förderung dynamischer Problemlösekompetenz in der Biologie
Creators: name: Rieß, Werner
name: Mischo, Christoph
Publisher: name: Zeitschrift für Didaktik der Biologie (ZDB) - Biologie Lehren und Lernen
Year: 2017

description: Die Förderung naturwissenschaftsbezogener Problemlösekompetenz ist ein wichtiges Ziel der naturwissenschaftlichen Ausbildung an Schulen und Hochschulen. Wie aber können entsprechende Kompetenzen evidenzbasiert gefördert werden? Die Autoren referieren zunächst wichtige Merkmale und Konzepte des Problemlösens in naturwissenschaftlichen Kontexten, stellen anschließend Ansätze und Effekte eher instruktivistischer vs. konstruktivistischer Lehr-Lernverfahren zur Förderung von Problemlösefähigkeiten dar und diskutieren die empirische Befundlage kritisch. Auf der Basis vielfach empirisch bewährter Lehr-Lernprinzipien und in Anlehnung an ein Lehr-Lernmodell von Van Merriënboer (2013) entwickeln die Autoren ein Modell problemorientierten Lehrens und Lernens (MopoLL), das die Kluft zwischen bereichsübergreifenden und adressaten- sowie inhaltsunspezifischen Lehr-Lernmodellen einerseits und den Bedürfnissen praktisch Lehrender nach einer Konkretisierung für die Unterrichtsplanung andererseits überbrückt und als Ansatz zur evidenzbasierten Förderung dynamischer Problemlösekompetenz (zumindest) biologischer Inhalte gelten kann. Abschließend werden Desiderata für die weitere Forschung aufgezeigt.
description: Zeitschrift für Didaktik der Biologie (ZDB) - Biologie Lehren und Lernen, Bd. 21 (2017)
Barjols, près de l'abattoir, parachèvement de la décoration du char
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Presentation of activities of EUROAGEISM Horizont 2020 project (oral presentation in Czech)
Creators: name: Fialová, Daniela
Publisher: name: Zenodo
Year: 2019
Subjects: EUROAGEISM H2020 project
national presentation
FIP7 program EUROAGEISM H2020
inappropriate prescribing
aged

description: Activities of the whole EUROAGEISM H2020 project in all 15 FIPs were introduced at this national event, as well as activities of FIP7 "Inappropriate prescribing and availability of medication safety and medication management services in older patients in Europe and other countries" during the XXIIIrd Working days of clinical pharmacy in Prague, Czech Republic, on June 7th, 2019. Presentation (in Czech) was included in the Book of abstracts and ESR7 J. Brkič, MSc. helped to co-organize this event.
Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice
Creators: name: Kelly, Scott A.
name: Pomp, Daniel
name: Farber, Charles R.
name: Leamy, Larry J.
name: Hua, Kunjie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Osteoporosis, characterized by low levels of bone mineral density (BMD), is a prevalent medical condition in humans. We investigated its genetic and environmental basis by searching for quantitative trait loci (QTLs) affecting six skeletal (including three BMD) traits in a G10 advanced intercross population produced from crosses of mice from the inbred strain C57BL/6J with mice from a strain selected for high voluntary wheel running. The mice in this population were fed either a high-fat or a matched control diet throughout the study, allowing us to test for QTL by diet interactions for the skeletal traits. Our genome scan uncovered a number of QTLs, the great majority of which were different from QTLs previously found for these same traits in an earlier (G4) generation of the same intercross. Further, the confidence intervals for the skeletal trait QTLs were reduced from an average of 18.5 Mb in the G4 population to an equivalent of about 9 Mb in the G10 population. We uncovered a total of 50 QTLs representing 32 separate genomic sites affecting these traits, with a distal region on chromosome 1 harboring several QTLs with large effects on the BMD traits. One QTL was located on chromosome 5 at 4.0 Mb with a confidence interval spanning from 4.0 to 4.6 Mb. Only three protein coding genes reside in this interval, and one of these, Cyp51, is an attractive candidate as others have shown that developing Cyp51 knockout embryos exhibit shortened and bowed limbs and synotosis of the femur and tibia. Several QTLs showed significant interactions with sex, although only two QTLs interacted with diet, both affecting only mice fed the high-fat diet.
Barjols, près de l'abattoir, groupe d'hommes près du char décoré et chargé du boeuf embroché
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
A new two--parameter family of isomonodromic deformations over the five punctured sphere
Creators: name: Girand, Arnaud
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E22, 20G05, 20G20, 32D15, 32G08, 32G34, 34M50, 34M56, 51N15, 55R10

description: The object of this paper is to describe an explicit two--parameter family of logarithmic flat connections over the complex projective plane. These connections have dihedral monodromy and their polar locus is a prescribed quintic composed of a circle and three tangent lines. By restricting them to generic lines we get an algebraic family of isomonodromic deformations of the five--punctured sphere. This yields new algebraic solutions of a Garnier system. Finally, we use the associated Riccati one--forms to construct an interesting non--generic family of transversally projective Lotka--Volterra foliations.
description: English text, 30 pages
Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise
Creators: name: Galior, Kornelia
name: Wu, Xin
name: Kadari, Sanjay
name: Sen, Buer
name: Uzer, Gunes
name: Rubin, Janet
name: Romaine, Andrew
name: Case, Natasha
name: Xie, Zhihui
name: Horowitz, Mark C.
name: Styner, Martin A.
name: Rubin, Clinton T.
name: Pagnotti, Gabriel M.
name: Styner, Maya
name: Thompson, William R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Marrow adipose tissue (MAT), associated with skeletal fragility and hematologic insufficiency, remains poorly understood and difficult to quantify. We tested the response of MAT to high fat diet (HFD) and exercise using a novel volumetric analysis, and compared it to measures of bone quantity. We hypothesized that HFD would increase MAT and diminish bone quantity, while exercise would slow MAT acquisition and promote bone formation. Eight week-old female C57BL/6 mice were fed a regular (RD) or HFD, and exercise groups were provided voluntary access to running wheels (RD-E, HFD-E). Femoral MAT was assessed by μCT (lipid binder osmium) using a semi-automated approach employing rigid co-alignment, regional bone masks and was normalized for total femoral volume (TV) of the bone compartment. MAT was 2.6-fold higher in HFD relative to RD mice. Exercise suppressed MAT in RD-E mice by more than half compared with RD. Running similarly inhibited MAT acquisition in HFD mice. Exercise significantly increased bone quantity in both diet groups. Thus, HFD caused significant accumulation of MAT; importantly running exercise limited MAT acquisition while promoting bone formation during both diets. That MAT is exquisitely responsive to diet and exercise, and its regulation by exercise appears to be inversely proportional to effects on exercise induced bone formation, is relevant for an aging and sedentary population.
Microgravity control of autophagy modulates osteoclastogenesis
Creators: name: Bateman, Ted A.
name: Townsend, Molly T.
name: Reddy, Sakamuri V.
name: Sambandam, Yuvaraj
name: Pierce, Jason J.
name: Lipman, Cecilia M.
name: Haque, Azizul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Evidence indicates that astronauts experience significant bone loss during space mission. Recently, we used the NASA developed rotary cell culture system (RCCS) to simulate microgravity (μXg) conditions and demonstrated increased osteoclastogenesis in mouse bone marrow cultures. Autophagy is a cellular recycling process of nutrients. Therefore, we hypothesize that μXg control of autophagy modulates osteoclastogenesis. Real-time PCR analysis of total RNA isolated from mouse bone marrow derived non-adherent cells subjected to modeled μXg showed a significant increase in autophagic marker Atg5, LC3 and Atg16L mRNA expression compared to ground based control (Xg) cultures. Western blot analysis of total cell lysates identified an 8.0-fold and 7.0-fold increase in the Atg5 and LC3-II expression, respectively. Confocal microscopy demonstrated an increased autophagosome formation in μXg subjected RAW 264.7 preosteoclast cells. RT2 profiler PCR array screening for autophagy related genes identified that μXg upregulates intracellular signaling molecules associated with autophagy, autophagosome components and inflammatory cytokines/growth factors which coregulate autophagy in RAW 264.7 preosteoclast cells. Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in μXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation. Furthermore, RANKL treatment significantly increased (8-fold) p-CREB transcription factor levels under μXg as compared to Xg cultures and 3-MA inhibited RANKL increased p-CREB expression in these cells. Also, 3-MA suppresses μXg elevated osteoclast differentiation in mouse bone marrow cultures. Thus, our results suggest that μXg induced autophagy plays an important role in enhanced osteoclast differentiation and could be a potential therapeutic target to prevent bone loss in astronauts during space flight missions.
Study of ECG signal Processing for Reliable Detection and Distinguishing of atypical Beats in ECG Signals
Creators: name: E N, ganesh
Publisher: name: figshare
Year: 2022
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: An ECG signal processing algorithm for reliable detection and discrimination of atypical beats in electrocardiogram (ECG) is proposed. The optimal linear transform is derived from the first derivative signal that maximizes a certain criterion for distinguishing atypical beats from typical beats. These optimal transformations are assumed to be novel ECG leads in which atypical beats are enhanced and easily distinguished from typical beats. Two variants of the method with different optimization criteria are experimentally validated on a 4-channel ECG database of 42 recordings.
Comorbidity burden in patients with chronic GVHD
Creators: name: Wolff, D.
name: Arora, M.
name: Weisdorf, D.
name: Mitchell, S.
name: Wood, W. A.
name: Pidala, J.
name: Jagasia, M.
name: Lee, S. J.
name: Pavletic, S. Z.
name: Arai, S.
name: Inamoto, Y.
name: Cutler, C.
name: Palmer, J. M.
name: Chai, X.
name: Martin, P. J.
name: Storer, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chronic graft-versus-host disease (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients with cGVHD (n=239), we examined the performance of two comorbidity scales, the Functional Comorbidity Index (FCI) and the Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Both scales detected a higher number of comorbidities at cGVHD cohort enrollment than pre-HCT (p<0.001). Higher HCT-CI scores at the time of cGVHD cohort enrollment were associated with higher non-relapse mortality (HR 1.21:1.04–1.42,p=0.01). For overall mortality, we detected an interaction with platelet count. Higher HCT-CI scores at enrollment were associated with an increased risk of overall mortality when the platelet count was less than or equal to 100,000/µl (HR 2.01: 1.20–3.35, p=0.01), but not when it was greater than 100,000/µl (HR 1.05: 0.90–1.22, p=0.53). Comorbidity scoring may help better predict survival outcomes in patients with cGVHD. Further studies to understand vulnerability unrelated to cGVHD activity in this patient population are needed.
Comparing cervical mucus changes in response to an oral progestin or oestrogen withdrawal in ovarian-suppressed women: a clinical pilot
Creators: name: Han, Leo
name: Padua, Emily
name: Hart, Kyle D.
name: Edelman, Alison
name: Jensen, Jeffrey T.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Purpose: Prior studies evaluating the effect of administered progestogens on peak cervical mucus have not controlled for the influence of endogenous hormones. To address this, we treated women with a gonadotropin-releasing hormone (GnRH) agonist to suppress the hypothalamus–pituitary–ovarian (HPO) axis and used transdermal oestradiol replacement to stimulate peak cervical mucus and then evaluated the effects of an oral progestin or oestradiol withdrawal. Materials and methods: We used a crossover design to examine cervical mucus changes in women receiving transdermal oestradiol replacement following intramuscular administration of leuprolide acetate. After increasing oestradiol patches to mid-cycle levels, subjects were assigned to either 0.35 mg oral norethindrone with continuation of the patches (NET) or oestradiol withdrawal by patch removal (E2WD). We collected serum and cervical mucus samples at 0, 2, 4, 6, 22 and 24 h following the intervention. Results: We analysed 12 cycles (6 NET, 6 E2WD) from three subjects. Baseline cervical mucus scores were favourable to sperm penetration [NET median 11, interquartile range (9–12), E2WD 13 (12–13)]. Two hours after removal of oestradiol patch or administration of norethindrone, cervical mucus scores declined [NET 8.5 (4–9), E2WD 10.5 (10–12)]. Low cervical mucus scores persisted at 24 h with NET [8.0 (7–8)] but not E2WD [10.5 (8–11)]. Conclusions: We observed a rapid decline in cervical mucus Insler scores following administration of a single dose of oral norethindrone, and scores remained lower and unfavourable through 24 h. Oestradiol withdrawal did not result in similar unfavourable changes.
Effectiveness of etoposide chemomobilization in lymphoma patients undergoing auto-SCT
Creators: name: Rao, K. V.
name: Serody, J. S.
name: Goyal, R.
name: Armistead, P. M.
name: Coghill, J. M.
name: Gabriel, D. A.
name: Whitley, J.
name: Shea, T. C.
name: Brown, P. M.
name: Sharf, A.
name: Sarantopoulos, S.
name: Essenmacher, A.
name: Wood, W. A.
name: Irons, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The effectiveness of stem cell mobilization with G-CSF in lymphoma patients is suboptimal. We reviewed our institutional experience using chemomobilization with etoposide (VP-16; 375 mg/m2 on days +1 and +2) and G-CSF (5 μg/kg twice daily from day +3 through the final day of collection) in 159 patients with lymphoma. This approach resulted in successful mobilization (>2 × 106 CD34+ cells collected) in 94% of patients (83% within 4 apheresis sessions). Fifty-seven percent of patients yielded at least 5 × 106 cells in 2 days and were defined as good mobilizers. The regimen was safe with a low rate of rehospitalization. Average costs were $14 923 for good mobilizers and $27 044 for poor mobilizers (P<0.05). Using our data, we performed a ‘break-even’ analysis that demonstrated that adding two doses of Plerixafor to predicted poor mobilizers at the time of first CD34+ cell count would achieve cost neutrality if the frequency of good mobilizers were to increase by 21%, while the frequency of good mobilizers would need to increase by 25% if three doses of Plerixafor were used. We conclude that chemomobilization with etoposide and G-CSF in patients with lymphoma is effective, with future opportunities for cost-neutral improvement using novel agents.
Barjols, près de l'abattoir, parachèvement de la décoration du char chargé du boeuf embroché
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD
Creators: name: Jagasia, M.
name: Jacobsohn, D.
name: Palmer, J.
name: Pavletic, S. Z.
name: Weisdorf, D.
name: Carpenter, P. A.
name: Khera, N.
name: Lee, S. J.
name: Inamoto, Y.
name: Pidala, J.
name: Flowers, M. E.D.
name: Martin, P. J.
name: Wood, W. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The 2005 National Institutes of Health (NIH) consensus criteria for chronic graft-versus-host disease (cGVHD) have set standards for reporting. Many questions, however, have arisen regarding implementation and utilization. To identify perceived areas of controversy, we conducted an international survey on diagnosis and scoring of cGVHD. Agreement was observed for 50% to 83% of the 72 questions in 7 topic areas. There was agreement in the need for modifying criteria in 6 situations: 2 or more distinctive manifestations should be enough to diagnose cGVHD, symptoms not due to cGVHD should be scored differently, active disease and fixed deficits should be distinguished, a minimum threshold body surface area of hidebound skin involvement should be required for a skin score 3, asymptomatic oral lichenoid changes should be considered a score 1, and lung biopsy should be unnecessary to diagnose cGVHD in a patient with bronchiolitis obliterans as the only manifestation. The survey also identified 26 points of controversy. Whenever possible, studies should be conducted to confirm the appropriateness of any revisions. In cases where data are not available, clarification of the NIH recommendations by consensus is necessary. This survey should inform future research in the field and revisions of the current consensus criteria.
Comparing cervical mucus changes in response to an oral progestin or oestrogen withdrawal in ovarian-suppressed women: a clinical pilot
Creators: name: Han, Leo
name: Padua, Emily
name: Hart, Kyle D.
name: Edelman, Alison
name: T. Jensen, Jeffrey
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Purpose: Prior studies evaluating the effect of administered progestogens on peak cervical mucus have not controlled for the influence of endogenous hormones. To address this, we treated women with a gonadotropin-releasing hormone (GnRH) agonist to suppress the hypothalamus–pituitary–ovarian (HPO) axis and used transdermal oestradiol replacement to stimulate peak cervical mucus and then evaluated the effects of an oral progestin or oestradiol withdrawal. Materials and methods: We used a crossover design to examine cervical mucus changes in women receiving transdermal oestradiol replacement following intramuscular administration of leuprolide acetate. After increasing oestradiol patches to mid-cycle levels, subjects were assigned to either 0.35 mg oral norethindrone with continuation of the patches (NET) or oestradiol withdrawal by patch removal (E2WD). We collected serum and cervical mucus samples at 0, 2, 4, 6, 22 and 24 h following the intervention. Results: We analysed 12 cycles (6 NET, 6 E2WD) from three subjects. Baseline cervical mucus scores were favourable to sperm penetration [NET median 11, interquartile range (9–12), E2WD 13 (12–13)]. Two hours after removal of oestradiol patch or administration of norethindrone, cervical mucus scores declined [NET 8.5 (4–9), E2WD 10.5 (10–12)]. Low cervical mucus scores persisted at 24 h with NET [8.0 (7–8)] but not E2WD [10.5 (8–11)]. Conclusions: We observed a rapid decline in cervical mucus Insler scores following administration of a single dose of oral norethindrone, and scores remained lower and unfavourable through 24 h. Oestradiol withdrawal did not result in similar unfavourable changes.
A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma
Creators: name: Satwani, P.
name: Kamble, R. T.
name: Cohen, J. B.
name: Vose, J. M.
name: Nishihori, T.
name: Ganguly, S.
name: Keating, A.
name: Hertzberg, M. S.
name: Olsson, R. F.
name: Cashen, A.
name: Ahn, K. W.
name: Cairo, M. S.
name: Smith, S. M.
name: Dandoy, C.
name: Hayashi, R. J.
name: Ghosh, N.
name: Fenske, T. S.
name: Gale, R. P.
name: Costa, L. J.
name: Prestidge, T. D.
name: Abdel-Azim, H.
name: Chen, A. I.
name: Kharfan-Dabaja, M. A.
name: Savani, B. N.
name: Rolon, J. M.
name: Inwards, D. J.
name: Freytes, C. O.
name: Sureda, A.
name: Carreras, J.
name: Kanate, A. S.
name: Marks, D. I.
name: Bachanova, V.
name: Maloney, D. G.
name: Hamadani, M.
name: Wood, W. A.
name: Lazarus, H. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Autologous hematopoietic cell transplantation (AutoHCT) is a potentially curative treatment modality for relapsed/refractory Hodgkin lymphoma (HL). However, no large studies have evaluated pre-transplant factors predictive of outcomes of AutoHCT in children, adolescents and young adults (CAYA, age <30 years). In a retrospective study, we analyzed 606 CAYA patients (median age 23 years) with relapsed/refractory HL who underwent AutoHCT between 1995–2010. The probabilities of progression free survival (PFS) at 1, 5 and 10 years were 66% (95% CI: 62–70), 52% (95% CI: 48–57) and 47% (95% CI: 42–51), respectively. Multivariate analysis for PFS demonstrated that at the time of AutoHCT patients with Karnofsky/Lansky score ≥90, no extranodal involvement and chemosensitive disease had significantly improved PFS. Patients with time from diagnosis to first relapse of <1 year had a significantly inferior PFS. A prognostic model for PFS was developed that stratified patients into low, intermediate and high-risk groups, predicting for 5-year PFS probabilities of 72% (95% CI: 64–80), 53% (95% CI: 47–59) and 23% (95% CI: 9–36), respectively. This large study identifies a group of CAYA patients with relapsed/refractory HL who are at high risk for progression after AutoHCT. Such patients should be targeted for novel therapeutic and/or maintenance approaches post-AutoHCT.
A presente memoria ovvero Perché questo lavoro s'ha da fare...
Creators: name: Ribaudo, Masi (Tommaso)
Publisher: name: Zenodo
Year: 2013
Subjects: Intangible Cultural Heritage, Literature, Sound Libraries, Digital Archives, Radio Broadcasts, RAI, CRICD, Sicily

description: Published on L’intellettuale al caffè: incontri con testimoni e interpreti del nostro tempo. Interviste a Leonardo Sciascia, Vincenzo Consolo, Gesualdo Bufalino, Ignazio Buttitta. CRICD Regione Siciliana, Palermo 2013. ISBN 978-88-904949-9-4 Index: Un viaggio radiofonico nei luoghi simbolo della Sicilia
 Giulia Davì
 Il labirinto delle voci
 Salvatore Cusimano
 Le ragioni dell’ascolto
 Orietta Sorgi
 I miei amici scrittori. Conversazione con Aldo Scimè
 Salvatore Cusimano
 Per Ignazio
 Antonino Buttitta
 Sentire le voci
 Matteo Di Gesù
 Leonardo Sciascia, la sua voce
 Marcello Benfante
 Utopie e disincanti nella scrittura di Consolo
 Flora Di Legami
 Quel tarlo mai sazio
 Salvatore Ferlita
 Pesci
 Gian Mauro Costa
 A presente memoria ovvero Perché questo lavoro s’ha da fare...
 Masi Ribaudo
 Le Teche RAI e le trasmissioni d’argomento letterario. Un tesoro da (ri)scoprire
 Maurizio Zerbo
 L’intellettuale al caffè. Incontri con testimoni e interpreti del nostro tempo
 Loredana Cacicia
 Guida all’ascolto de “La cultura e i suoi luoghi”
 Sergio Palumbo
 GUIDA ALL’ASCOLTO DEI CD
 CD 1
 CD 2 Book downloadable at http://www.arcadeisuoni.org/index.php/download/file/19-l-intellettuale-al-caff%C3%A8
description: CRICD Regione Siciliana http://www.cricd.it/ - RAI Regione Siciliana http://www.regionesicilia.rai.it/dl/sicilia/hp/Page-6bbde67e-e04d-48c0-809f-44d388256eee.html
Allogeneic hematopoietic cell transplant for AML: no impact of pre-transplant extramedullary disease on outcome
Creators: name: Freytes, C.
name: Copelan, E. A.
name: Gale, R. P.
name: Bunjes, D. W.
name: Tallman, M. S.
name: Kamble, R. T.
name: De Lima, M.
name: Savani, B. N.
name: Goyal, S. D.
name: Uy, G. L.
name: Reshef, R.
name: Lazarus, H. M.
name: Akpek, G.
name: Nishihori, T.
name: Wang, H. L.
name: Inamoto, Y.
name: Ritchie, D. S.
name: Wirk, B.
name: Zhang, M. J.
name: Marks, D. I.
name: Hamadani, M.
name: Olsson, R. F.
name: Weisdorf, D. J.
name: Seber, A.
name: Devine, S. M.
name: Saber, W.
name: Shea, T. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The impact of extramedullary disease (EMD) in AML on the outcomes of allogeneic hematopoietic cell transplantation (alloHCT) is unknown. Using data from the Center for International Blood and Marro ...
Electromagnetic fields with vanishing scalar invariants
Creators: name: Ortaggio, Marcello
name: Pravda, Vojtěch
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We determine the class of $p$-forms $F$ which possess vanishing scalar invariants (VSI) at arbitrary order in a $n$-dimensional spacetime. Namely, we prove that $F$ is VSI if and only if it is of type N, its multiple null direction $l$ is "degenerate Kundt", and $\nabla_{l}F=0$. The result is theory-independent. Next, we discuss the special case of Maxwell fields, both at the level of test fields and of the full Einstein-Maxwell equations. These describe electromagnetic non-expanding waves propagating in various Kundt spacetimes. We further point out that a subset of these solutions possesses a universal property, i.e., they also solve (virtually) any generalized (non-linear and with higher derivatives) electrodynamics, possibly also coupled to Einstein's gravity.
description: v2: a few comments added (including new Proposition A3), minor corrections, main results unchanged. 24 pages
Science, Identity and Belonging: Engaging through co-design with young people at a science museum: a qualitative study of process
Creators: name: Skatun, Torhild
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: The Science, identity and belonging (SIB) research project aims at shedding light on codesign processes from several perspectives from within the educational department of a science museum. Over a period of four years, an interdisciplinary museum team has collaborated with a group of young people. With the research and temporary exhibition project FOLK from racial types to DNA sequences (FOLK) as the pivot point, two phases of co-design workshops have been facilitated. First eight sessions resulting in the digital sound installation the Sound of FOLK, followed by a workshop where we collaborated with two partners from phase one arranging a workshop with children in the FOLK exhibition. SIB illuminates how a museum can connect with young people outside of school hours and through it disrupt how museums think about their educational role in society. Moreover, co-design gives opportunities for young people to enter into close conversation on topics that are difficult, complex and sensitive, interchanges that can be used in acting as humans in the society. This practice-based PhD has resulted in three academic papers: One investigates how co-design has an impact on curatorial reflexivity, a second thematizes how co-design can foster engagement in the interaction between museum professionals and youths.The third looks more closely at how knowledge develops and travels from partaking in collaboration of a digital installation into a post-production phase co-facilitating an activity program. A professional paper elaborates on the usage of Future workshop and a podcast discuss how co-design encourage socially engaged practices. The SIB process has highlighted issues around the sharing of museum authority, multivocality, long-term partnerships, mutual learning and experts working along non-experts. It explores how museum development can include external partners in reflexive processes, and how it in turn ensures a process that is rewarding for all partners involved.
Barjols, foule masculine massée devant la collégiale
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Jet Luminosity of Gamma-ray Bursts: Blandford-Znajek Mechanism v.s. Neutrino Annihilation Process
Creators: name: Liu, Tong
name: Hou, Shu-Jin
name: Xue, Li
name: Gu, Wei-Min
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A neutrino-dominated accretion flow (NDAF) around a rotating stellar-mass black hole (BH) is one of the plausible candidates for the central engine of gamma-ray bursts (GRBs). Two mechanisms, i.e., Blandford-Znajek (BZ) mechanism and neutrino annihilation process, are generally considered to power GRBs. Using the analytic solutions from Xue et al. (2013) and ignoring the effects of the magnetic field configuration, we estimate the BZ and neutrino annihilation luminosities as the functions of the disk masses and BH spin parameters to contrast the observational jet luminosities of GRBs. The results show that, although the neutrino annihilation processes could account for most of GRBs, the BZ mechanism is more effective, especially for long-duration GRBs. Actually, if the energy of afterglows and flares of GRBs is included, the distinction between these two mechanisms is more significant. Furthermore, massive disk mass and high BH spin are beneficial to power high luminosities of GRBs. Finally, we discuss possible physical mechanisms to enhance the disk mass or the neutrino emission rate of NDAFs and relevant difference between these two mechanisms.
description: 20 pages, 3 tables, 2 figures, accepted for publication in ApJS
title: Effects of Soil Amendments on Water Quality and Hydrologic Properties in Low Impact Development Systems
Creators: name: Wetterlin, Lily
Publisher: name: Utah State University
Year: 2023

description: Low impact development (LID) systems are practices that use natural elements, such as soils and vegetation, to absorb and filter stormwater to protect water quality and aquatic habitats. Many LID designs use native soils; however, urban soils typically have a limited potential for infiltrating and treating stormwater. Incorporation of soil amendments, such as compost and biochar, into LID soils can improve the physical properties of soil. However, soil amendments may increase or decrease pollutants in the water leaving the site. A comparison of the effects of different types and application rates of amendments on water quality is necessary to determine the appropriate use of amendments in LID systems. The objective of this study was to evaluate the use of soil amendments in LID systems by examining the effects of sources and amendment rates on soil properties and water quality. Water draining from soils amended with three types of compost and one type of biochar at different amendment rates (0, 5, 10, 25, and 50% by volume) were monitored during five simulated storm events. Results showed that compost treatments increased nitrate and phosphate concentrations, with higher concentrations occurring with higher amendment rates. Nitrate was flushed from the soils within the first storm events, and phosphate was released steadily across all five storms. Biochar exported less nutrients than the compost treatments, and ammonium, copper, lead, and zinc were removed in all treatments. The export of dissolved arsenic resulted from the addition of all amendments to the control soil and was closely linked to dissolved organic carbon. The chemistry and amendment rates of compost and biochar were the primary drivers of pollutant export. Overall, biochar improved water quality and soil physical properties to a greater degree than compost. This study shows that amendment type and amendment rate can affect water quality when utilized in LID. Biochar was shown to outperform compost in water quality treatment and may be an optimal soil amendment source where available. The results of this study will help inform guidelines in statewide design standards for LID practices using soil amendments to improve stormwater capture and treatment.
title: The Relationship Between Career Choice and Indecision Within the Career and Technical Education Pathway Model
Creators: name: Konakis, Zak A.
Publisher: name: Utah State University
Year: 2023

description: The United States is shifting the public education model toward one that favors increasing skill complexity to lead students into future careers. It is uncertain, however, if these changes are benefiting students and having the desired impact on the future workforce. Utilizing the Swiss and German dual apprenticeship and work-based learning model, Utah is attempting to bring more practical and hands-on experiential learning opportunities to students across the state. This study intended to understand if these changes are accomplishing the intended result in students in rural eastern Utah.
Furthermore, the study found that students who engage in early experiential learning opportunities in these rural counties were more likely to begin planning their career decisions. Individual career pathways were not a significant indicator of career decision-making ability for rural Utah students. However, the perceived difficulty and awareness of career choice anxiety was the most significant indicator for career-choice dysfunction within the model.
Future research will expand the research group and identify if characteristics indicate Carbon and Emery County school districts or are symptomatic across the secondary education system. Additional research on ameliorating choice anxiety will be undertaken with the intention of positive intervention strategies that lead to confident career choices.
title: Big Fish and More of Them: Salmonid Habitat Availability, Quality, and Use Across Multiple Scales Within a River-Reservoir System
Creators: name: McLaren, John S.
Publisher: name: Utah State University
Year: 2023

description: Reservoirs and their associated rivers provide water for agricultural and municipal uses, ecological benefits for fish and wildlife, and associated recreational activity. However, in the Greater Yellowstone Ecosystem climate change and population growth are putting pressure on water quality and supply, potentially damaging the unique and economically important coldwater trout habitat that these systems support. In this study, the author investigates the impact of changing water quality and supply on trout habitat quality, quantity, and selection to assist conservation goals in the Henry’s Fork Watershed in eastern Idaho. The study found that higher availability of cold-water refuge habitat in Island Park Reservoir during the hot summer months increased trout and salmon populations. The amount of cold-water refuge habitat was positively related to Island Park Reservoir water levels. The study also found that submerged aquatic vegetation were a critical part of fish habitat in the Henry’s Fork River, creating habitats that could provision both food and predator avoidance simultaneously. This study also found that increasing submerged aquatic vegetation in the Henrys Fork River has the potential to affect fish movement to improve angling. More research is needed to determine the net effect of submerged aquatic vegetation on trout populations in river ecosystems. This study highlights the importance of refuge habitat and reservoir conditions to fish populations in connected river-reservoir systems, as well as the importance of submerged aquatic vegetation for trout habitat quantity, quality, and preferences. The findings of this study have important implications for adaptive management actions that seek to improve fish habitat refuges while maintaining important water supply benefits for all stakeholders.
title: Durability of Wireless Charging Systems Embedded Into Concrete Pavements for Electric Vehicles
Creators: name: Vaikasi, Pilaiwan
Publisher: name: Utah State University
Year: 2023

description: The interest in electric vehicles (EVs) has been growing around the world significantly. EVs run on electricity by charging power to their batteries. However, a concern in the operation of the EVs is raised because they have an insufficient battery charge to reach their destination. In-motion, inductive power transfer (IPT) embedded into the roadway for the EVs can ease the need to use a charging stationary. This project focused on the durability of the dynamic charging IPT electronics integrated into concrete pavements. This research collaborated with electrical and mechanical engineering colleagues from the Advancing Sustainability through Powered Infrastructure for Roadway Electrification (ASPIRE) at Utah State University to develop dynamic charging. The mechanical behavior of the electrified precast concrete pavement (EPCP) was examined through a 3D finite element analysis (FEA) model in ANSYS and an experimental work. The EPCPs were subjected to cyclic thermal load from the IPT operation and structural load from a heavy truck. The ultimate failure loading test was conducted to determine the flexural strength of the EPCPs. For the physical test, the EPCP panel specimens were constructed. Embedded fiber optic strain and temperature gauges collected data from IPT heat load in the thermal testing. The internal embedded fiber optic and external strain gauges measured the strain data in the cyclic wheel load testing. For model validation, the results of the FEA models, such as strain and crack patterns on the concrete, were calibrated with the experimental data from strain and temperature readings. Then, the models were updated to develop reasonable mechanical behavior of the entire structure.
Helical bunching and symmetry lowering inducing multiferroicity in Fe langasites
Creators: name: Chaix, Laura
name: Ballou, Rafik
name: Cano, Andres
name: Petit, Sylvain
name: De Brion, Sophie
name: Ollivier, Jacques
name: Regnault, Louis-Pierre
name: Ressouche, Eric
name: Constable, Evan
name: Colin, Claire
name: Zorko, A.
name: Scagnoli, Valerio
name: Balay, Joël
name: Lejay, Pascal
name: Simonet, Virginie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The chiral Fe-based langasites represent model systems of triangle-based frustrated magnets with a strong potential for multiferroicity. We report neutron scattering measurements for the multichiral Ba3MFe3Si2O14 (M = Nb, Ta) langasites revealing new important features of the magnetic order of these systems: the bunching of the helical modulation along the c-axis and the in-plane distortion of the 120{\textdegree} Fe-spin arrangement. We discuss these subtle features in terms of the microscopic spin Hamiltonian, and provide the link to the magnetically-induced electric polarization observed in these systems. Thus, our findings put the multiferroicity of this attractive family of materials on solid ground.
title: Generalizing Deep Learning Methods for Particle Tracing Using Transfer Learning
Creators: name: Gupta, Shubham
Publisher: name: Utah State University
Year: 2023

description: Particle tracing is a very important method for scientific visualization of vector fields, but it is computationally expensive. Deep learning can be used to speed up particle tracing, but existing deep learning models are domain-specific. In this work, we present a methodology to generalize the use of deep learning for particle tracing using transfer learning. We demonstrate the performance of our approach through a series of experimental studies that address the most common simulation design scenarios: varying time span, Reynolds number, and problem geometry. The results show that our methodology can be effectively used to generalize and accelerate the training and practical use of deep learning models for visualization of unsteady flows.
Barjols, près de l'abattoir, groupe masculin à côté du char chargé du boeuf embroché
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Barjols, place de la Rouguière, gros plan sur le boeuf embroché
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract