Additional file 1 of Mean arterial pressure during cardiopulmonary bypass: A modifiable risk factor for acute kidney injury in cardiac surgery patients?
Creators: name: Schreiber, Nikolaus
name: Orlob, Simon
name: Fida, Stephanie
name: Klivinyi, Christoph
name: Kirsch, Alexander H.
name: Kolland, Michael
name: Schörghuber, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Additional file 1: Table S1. Baseline demographics, clinical characteristics and results. Data are reported as medians (with 25th–75th percentile in brackets) or as absolute counts (with percent in brackets). P-Values are derived from rank-sum tests. Odds ratios are derived from multivariable logistic regression models adjusted for covariates selected based on clinical plausibility: age, sex, weight, type of surgery, emergency surgery, ASA status, KDIGO—eGFR strata at admission, EuroSCORE II, diabetes mellitus, heart failure, hypertension, COPD, peripheral vascular disease, preoperative beta-blocker use, preoperative RAAS blockade, preoperative calcium antagonist use, total vasopressor-inotrope dose, fluid balance during surgery, TWA MAP under 65 mmHg during the post-CPB period, CPB time and units of pRBCs transfused intraoperatively. aORs—adjusted odds ratios; ASA—American Society of Anesthesiologists; AUC—area under the curve; CABG—coronary artery bypass grafting; CPB—cardiopulmonary bypass; CSA-AKI—cardiac surgery-associated acute kidney injury; CRRT—continuous renal replacement therapy; COPD—chronic obstructive pulmonary disease; eGFR—estimated glomerular filtration rate; KDIGO—Kidney Diseases: Improving Global Outcomes; MAP—mean arterial pressure; TWA—time-weighted average; pRBCs—packed red blood cells; RAAS—renin angiotensin aldosterone system. Table S2. Crude ORs for CSA-AKI from univariate logistic regression and adjusted ORs for CSA-AKI from multivariable logistic regression. aORs—adjusted odds ratios; ASA—American Society of Anesthesiologists; CABG—coronary artery bypass grafting; CI—confidence interval; COPD—chronic obstructive pulmonary disease; CPB—cardiopulmonary bypass; CSA-AKI—cardiac surgery-associated acute kidney injury; eGFR—estimated glomerular filtration rate; KDIGO—Kidney Diseases: Improving Global Outcomes; MAP—mean arterial pressure; min—minutes; pRBCs—packed red blood cells; RAAS—renin angiotensin aldosterone system; TWA—time-weighted average. Table S3. Time-weighted average mean arterial pressure under 75 mmHg and its effect on CSA-AKI and postoperative need of CRRT. We recalculated the TWA-MAP under 75 mmHg for both during and after the CPB period and then applied multivariable logistic regression models, adjusting for the same covariates as in our primary analysis. aORs—adjusted odds ratios; AUC—area under the curve; CSA-AKI—cardiac surgery-associated acute kidney injury; CI—confidence interval; CRRT—continuous renal replacement therapy; MAP—mean arterial pressure; TWA—time-weighted average. Table S4. Subgroup analysis separating patients with and without history of hypertension. The multivariable logistic regression models were adjusted for the same set of covariates as in the primary analysis except for prior hypertension. aORs—adjusted odds ratios; CSA-AKI—cardiac surgery-associated acute kidney injury; CI—confidence interval; MAP—mean arterial pressure; TWA—time-weighted average.