cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Geometric phases of d-wave vortices in a model of lattice fermions
Creators: name: Zhou, Zhenyu
name: Vafek, Oskar
name: Seidel, Alexander
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the local and topological features of Berry phases associated with the adiabatic transport of vortices in a d-wave superconductor of lattice fermions. At half filling, where the local Berry curvature must vanish due to symmetries, the phase associated with the exchange of two vortices is found to vanish as well, implying that vortices behave as bosons. Away from half filling, and in the limit where the magnetic length is large compared to the lattice constant, the local Berry curvature gives rise to an intricate flux pattern within the large magnetic unit cell. This renders the Berry phase associated with an exchange of two vortices highly path dependent. However, it is shown that "statistical" fluxes attached to the vortex positions are still absent. Despite the complicated profile of the Berry curvature away from half filling, we show that the average flux density associated with this curvature is tied to the average particle density. This is familiar from dual theories of bosonic systems, even though in the present case, the underlying particles are fermions.
description: 5 pages, 1 figure
Additional file 2: of MicroRNA-374a, -4680, and -133b suppress cell proliferation through the regulation of genes associated with human cleft palate in cultured human palate cells
Creators: name: Suzuki, Akiko
name: Li, Aimin
name: Gajera, Mona
name: Abdallah, Nada
name: Zhang, Musi
name: Zhao, Zhongming
name: Iwata, Junichi
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Table S2. Gene mutations found in cases of human CP. (PDF 704 kb)
Character sums for primitive root densities
Creators: name: Lenstra, H. W.
name: Moree, P.
name: Stevenhagen, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: Primary 11R45, Secondary 11L03, 11N13

description: It follows from the work of Artin and Hooley that, under assumption of the generalized Riemann hypothesis, the density of the set of primes $q$ for which a given non-zero rational number $r$ is a primitive root modulo $q$ can be written as an infinite product $\prod_p δ_p$ of local factors $δ_p$ reflecting the degree of the splitting field of $X^p-r$ at the primes $p$, multiplied by a somewhat complicated factor that corrects for the `entanglement' of these splitting fields. We show how the correction factors arising in Artin's original primitive root problem and some of its generalizations can be interpreted as character sums describing the nature of the entanglement. The resulting description in terms of local contributions is so transparent that it greatly facilitates explicit computations, and naturally leads to non-vanishing criteria for the correction factors. The method not only applies in the setting of Galois representations of the multiplicative group underlying Artin's conjecture, but also in the GL$_2$-setting arising for elliptic curves. As an application, we compute the density of the set of primes of cyclic reduction for Serre curves.
description: 23 pages. This version is to appear in the Mathematical Proceedings of the Cambridge Philosophical Society
Lembit Põlma välipäevik nr 27
Creators: name: Põlma, Lembit
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1986
Subjects: Ordovician
drill cores
Latvia
Kaliningrad Oblast
geological descriptions
lithology

description: Field notebook with descriptions of Ordovician drill cores from Latvia and Kaliningrad Oblast.
Mexican refugee claimants : cheating the system?
Creators: name: Abogado, Andrés
Publisher: name: University of British Columbia
Year: 2014

description: Between the years 2008 and 2009, Mexican refugee claims accounted for 25% of the total amount of applications for asylum made in Canada. However, the rate of acceptance of this particular group went as low as 11% in 2008 and 9% in 2009. For the Canadian government, these numbers were an indicator of fraud on the part of Mexicans who just wanted to collect welfare benefits and immigrate as economic refugees. In 2009, in an attempt to decrease these numbers, the Canadian government imposed visa restrictions in order prevent Mexicans from getting into Canada without having a pre-screening process. In 2012, Canada added Mexico onto a list of countries considered safe, as a means of preventing them from appealing adverse decisions and to expedite their claims for asylum. These measures were criticized by Canadian refugee scholars and the press on the basis that the Canadian government was ignoring the reality of thousands of Mexicans who are in need of international protection. Nevertheless, despite all the attention and controversy about Mexican refugees, there has been no in-depth analysis of this issue from a legal perspective. Because a refugee determination requires the participation of the claimant and the adjudicator, the author felt it not fair to treat Mexicans as the sole source of the problem, while failing to question and examine the role played by the Canadian refugee decision makers in contributing to the high rates at which Mexican refugee claims are denied. In order to determine the degree of responsibility of the Canadian government in this situation, the author undertook a close examination of the Immigration and Refugee Board decisions that granted and denied refugee status to Mexicans. Their legal arguments are analyzed in order to determine if this administrative tribunal has been fairly applying the principles contained in the 1951 Refugee Convention and its interpretation by the Canadian courts. This thesis concludes with a general overview of the past and current practices of the Immigration and Refugee Board of Canada and analyses the role that the Canadian government plays in the high rate of denial of Mexican refugee claims.
A note on the observational evidence for the existence of event horizons in astrophysical black hole candidates
Creators: name: Bambi, Cosimo
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Black holes have the peculiar and intriguing property of having an event horizon, a one-way membrane causally separating their internal region from the rest of the Universe. Today astrophysical observations provide some evidence for the existence of event horizons in astrophysical black hole candidates. In this short paper, I compare the constraint we can infer from the non-observation of electromagnetic radiation from the putative surface of these objects with the bound coming from the ergoregion instability, pointing out the respective assumptions and limitations.
description: 4 pages, no figures. v2: some typos corrected
Scaling, Finite Size Effects, and Crossovers of the Resistivity and Current-Voltage Characteristics in Two-Dimensional Superconductors
Creators: name: Andersson, Andreas
name: Lidmar, Jack
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We revisit the scaling properties of the resistivity and the current-voltage characteristics at and below the Berezinskii-Kosterlitz-Thouless transition, both in zero and nonzero magnetic field. The scaling properties are derived by integrating the renormalization group flow equations up to a scale where they can be reliably matched to simple analytic expressions. The vortex fugacity turns out to be dangerously irrelevant for these quantities below Tc, thereby altering the scaling behavior. We derive the possible crossover effects as the current, magnetic field, or system size is varied, and find a strong multiplicative logarithmic correction near Tc, all of which is necessary to account for when interpreting experiments and simulation data. Our analysis clarifies a longstanding discrepancy between the finite size dependence found in many simulations and the current-voltage characteristics of experiments. We further show that the logarithmic correction can be avoided by approaching the transition in a magnetic field, thereby simplifying the scaling analysis. We confirm our results by large-scale numerical simulations, and calculate the dynamic critical exponent z, for relaxational Langevin dynamics and for resistively and capacitively shunted Josephson junction dynamics.
description: 5 pages, 2 figures
Stress-induced failure modes in high-tuning range RF MEMS varactors
Creators: name: Chokshi, Trushal
name: Peroulis, Dimitrios
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: In this paper we focus on electromechanical
modeling of high-tuning range MEMS varactors with a focus
on failures caused by residual compressive stress. In
particular, we quantitatively evaluate for the first time a
high-tuning range parallel-plate MEMS varactor in the presence
of residual compressive stress. A 3D model generated
in ANSYS agrees very favorably with the measured
data and explains non-ideal discontinuities in the varactor’s
C − V curve. It is interesting to note that, although the
failures considered in this paper are not encountered in
RF MEMS switches, they become particularly important
in analog MEMS varactors since they directly impact their
effective tuning range.
Highly linear 20 GHz-Micromixer in SiGe bipolar technology
Creators: name: Doand, M.N.
name: Dubuc, D.
name: Coustou, A.
name: Tournier, E.
name: Ancey, P.
name: Plana, R.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: An active mixer operating at 20 GHz based
on the Gilbert Micromixer topology was designed and
fabricated in SiGe technology. High performances are
measured and especially an excellent linearity for moderate
current consumption is demonstrated. The circuit shows an
Output IP3 of +12 dBm and a conversion gain Gc of +7.7 dB
for an optimum LO power of only -2 dBm. The bias current
in the entire circuit is only 25 mA for a chip size of 1.8 x 2
mm².
Entwicklung neuartiger 1,4-Dihydropyridine und deren Käfigdimere als MDR-Modulatoren in der Therapie von malignen Tumoren
Creators: name: Döring, Henry
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Ein Grund für das Versagen einer Krebstherapie kann unter anderem die Entwicklung einer multiple drug resistance (MDR) sein. Ein Mechanismus, der zur Entstehung einer MDR beiträgt, ist die Überexpression von ATP-binding cassette (ABC)-Transportern. Das multidrug resistance-associated protein (MRP) 4 spielt aufgrund seiner ubiquitären Verbreitung im Körper und Überexpression bei einigen Krebsarten eine tragende Rolle bei der Entstehung einer MDR. In dieser Arbeit wird die Synthese von 1,4-Dihydropyridinen sowie deren Umsetzung zu alkoholischen Käfigdimerstrukturen in zwei weiteren Reaktionsschritten beschrieben. Sowohl die Dihydropyridine als auch die alkoholischen Käfigdimere wurden auf ihr Inhibitionspotential gegenüber MRP4 getestet. Die drei aktivsten Substanzen zeigten im MTT-Zellassay mit 6-Mercaptopurin resensibilisierende Eigenschaften auf die resistente Colo357MRP4-Zelllinie. Verbindung 14 resensibiliserte die Zelllinie nahezu vollständig gegenüber 6-Mercaptopurin.
description: One reason for the failure of cancer therapy can be the development of multiple drug resistance (MDR). One mechanism that contributes to the development of MDR is the overexpression of ATP-binding cassette (ABC) transporters. The multidrug resistance-associated protein (MRP) 4 plays a major role in the development of MDR due to its ubiquitous distribution in the body and overexpression in several types of cancer. In this paper, the synthesis of 1,4-dihydropyridines and their conversion to alcoholic cage dimer structures in two further reaction steps are described. Both the dihydropyridines and the alcoholic cage dimers were tested for their inhibition potential against MRP4. The three most active compounds showed resensitising properties to the resistant Colo357MRP4 cell line in the MTT cell assay with 6-mercaptopurine. Compound 14 resensitised the cell line almost completely to 6-mercaptopurine.
Guaranteed clustering and biclustering via semidefinite programming
Creators: name: Ames, Brendan P. W.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optimization and Control (math.OC)
subject: Machine Learning (cs.LG)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Identifying clusters of similar objects in data plays a significant role in a wide range of applications. As a model problem for clustering, we consider the densest k-disjoint-clique problem, whose goal is to identify the collection of k disjoint cliques of a given weighted complete graph maximizing the sum of the densities of the complete subgraphs induced by these cliques. In this paper, we establish conditions ensuring exact recovery of the densest k cliques of a given graph from the optimal solution of a particular semidefinite program. In particular, the semidefinite relaxation is exact for input graphs corresponding to data consisting of k large, distinct clusters and a smaller number of outliers. This approach also yields a semidefinite relaxation for the biclustering problem with similar recovery guarantees. Given a set of objects and a set of features exhibited by these objects, biclustering seeks to simultaneously group the objects and features according to their expression levels. This problem may be posed as partitioning the nodes of a weighted bipartite complete graph such that the sum of the densities of the resulting bipartite complete subgraphs is maximized. As in our analysis of the densest k-disjoint-clique problem, we show that the correct partition of the objects and features can be recovered from the optimal solution of a semidefinite program in the case that the given data consists of several disjoint sets of objects exhibiting similar features. Empirical evidence from numerical experiments supporting these theoretical guarantees is also provided.
Vergleich der Weil-Osteotomie und der distalen minimalinvasiven metatarsalen Osteotomie zur Behandlung einer chronischen Metatarsalgie : eine klinische, radiologische und pedobarografische Analyse
Creators: name: Kröber, Isabella
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: In dieser Studie wurden 77 Patienten mit chronischer Metatarsalgie untersucht, welche mittels distaler minimalinvasiver metatarsaler Osteotomie (DMMO) (44 Füße) bzw. Weil-Osteotomie (40 Füße) behandelt wurden. Es erfolgten prä –und postoperativ klinische, radiologische und pedobarografische Untersuchungen mit Bestimmung des Foot Function Index bzw. American Orthopaedic Foot and Ankle Society (AOFAS)-Vorfußsscores. In beiden Gruppen zeigte sich eine deutliche Verbesserung des AOFAS-Scores. Nach Weil-Osteotomie wurden signifikant häufiger Wundheilungsstörungen und –infektionen beobachtet. Die radiologischen Ergebnisse waren vergleichbar. Es konnte eine verbesserte Druckverteilung unter dem Vorfuß erzielt werden, mit signifikanter Mehrbelastung des lateralen Vorfußes nach Weil-Osteotomie. Im Rahmen der Vorfußkorrektur bietet die DMMO mehr Vorteile als die Weil-Osteotomie und sollte insbesondere bei Patienten mit Risikoprofil bevorzugt werden.
description: In this study, 77 patients with chronic metatarsalgia treated by distal minimally invasive metatarsal osteotomy (DMMO) (44 feet) or Weil osteotomy (40 feet) were examined. Pre- and postoperative clinical, radiological, and pedobarographic examinations were performed with determination of the Foot Function Index and American Orthopaedic Foot and Ankle Society (AOFAS) forefoot score. Both groups showed a significant improvement in the AOFAS score. Wound healing problems and infections were observed significantly more often after Weil osteotomy. Radiological results were comparable. Improved pressure distribution under the forefoot was achieved, with significantly increased loading of the lateral forefoot after Weil osteotomy. In the context of forefoot correction, DMMO offers more advantages than Weil osteotomy and should be preferred, especially in patients with a risk profile.
A wideband balanced AlGaN/GaN HEMT MMIC low noise amplifier for transceiver front-ends
Creators: name: Seo, Sanghyun
name: Pavlidis, Dimitris
name: Moon, Jeong-Sun
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: A 3-16 GHz wideband AlGaN/GaN high
electron mobility transistor (HEMT) low noise amplifier
(LNA), using balanced configuration with a coplanar
waveguide (CPW) Lange coupler, is designed and fabricated.
The LNA shows a minimum noise figure of 4 dB with
associated gain of 20 dB and gain flatness of +/
SPDT RF MEMS switch using a single bias voltage and based on dual series and shunt capacitive MEMS switches
Creators: name: Ketterl, T.
name: Weller, T.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: A coplanar waveguide (CPW) single-pole double-throw (SPDT) X-band RF MEMS switch that can be actuated between states by applying a single voltage is introduced. Since a signal can be transmitted to one of the output ports without biasing, this has the potential to reduce the complexity of the required biasing network. The switch consists of a series and a shunt capacitive MEMS switch separated by a quarter wavelength transmission line. The shunt switch section was fabricated and measured separately and shown to have an insertion loss of 0.25 dB and isolation of 33 dB at 10 GHz. A SPDT 3-port switch was fabricated and port isolations of about 15 dB and an insertion loss of 1 dB were obtained in the up-state. In the down-sate, 40 dB of isolation with a 1 dB insertion loss were measured. The actuation voltage was 35 V.
God in National Constitutions
Creators: name: Mager, Robert
Publisher: name: International Academy of Practical Theology. Conference Series
Year: 2021

description: Political constitutions often entail references to God, even in modern secularized countries. Those references testify to very salient political issues, and they are normally analyzed as such, either from a historical, political or legal perspective. This article adopts a theological point of view to explore the different ways in which God is referred to in national constitutions and the significance of such mentions. Four representations are identified: God as Liberator, Ruler, Judge or Creator. Those various ways of referring to God testify to the traditional theologico-political problem: how can a contingent political sphere be related to an absolute foundation? Constitutional references to God represent an attempt to achieve such a connection, but many are questionable from a theological point of view. The main issue for political discourse might be to find other ways to hint at transcendence.
description: International Academy of Practical Theology. Conference Series, Vol 2 (2021): (De)coloniality and religious practices: liberating hope; edited by Valburga Schmiedt Streck, Júlio Cézar Adam and Cláudio Carvalhaes
Fatty acid-modified poly(glycerol adipate) as a versatile matrix for parenteral depot formulations
Creators: name: Steiner, Jonas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Fettsäuremodifiziertes Poly(glyceroladipat) (FA-PGA) ist ein neuartiges bioabbaubares Polymer mit großem Potenzial für die Verwendung in verschiedenen parenteralen Depotarzneiformen. Durch die Veresterung der freien Hydroxylgruppe der PGA-Hauptkette mit verschiedenen Fettsäuren ist eine flexible Anpassung der Polymereigenschaften möglich. Diese FA-PGAs dienten als Matrices für die Herstellung von Mikropartikeln und vorgeformten Implantaten. Es war möglich die Eigenschaften dieser Depotarzneiformen durch die unterschiedlichen Polymermodifikationen zu optimieren und verschiedene Freisetzungsprofile zu erreichen. Die gute Verträglichkeit ausgewählter Mikropartikelformulierungen konnte im Mausmodell belegt werden. Durch einen Vergleich mit PLGA-Mikropartikeln konnte die Position von FA-PGA als Alternative zu PLGA gefestigt werden.
description: Fatty acid-modfied poly(glycerol adipate) is a novel biodegradable polymer with great potential for the preparation of various parenteral depot formulations. Through esterification of the pendant hydroxyl group in the PGA-backbone with different fatty acids, a flexible adjustment of the polmer’s properties is possible. These FA-PGAs served as matrices for the preparation of microparticles and preformed implants. By modification of the polymer, the optimization of the corresponding depot formulation was achieved and different release profiles were obtained. The good tolerability of the microparticle formulations was demonstrated in the mouse model. By comparison to PLGA microparticles the position of FA-PGA as an alternative to PLGA was consolidated.
Psychometrische Analyse des Beck Depressions-Inventars-II mittels Item Response Theorie
Creators: name: Wittmann, Johanna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Ziel der Studie war es, die psychometrischen Charakteristika des deutschen Beck Depressions-Inventars-II (BDI-II) mittels Item Response Theorie (IRT) zu analysieren. Hierfür erfolgte anhand einer Stichprobe junger Menschen (n=2419) eine strukturierte Evaluation der Eignung des BDI-II für IRT-Analysen, eine schrittweise Auswertung der IRT-Analyse, sowie eine Evaluation auf differentielle Itemfunktionsweise bzgl. Alter und Geschlecht. Die Items deckten mit ihren Schwierigkeitsparametern ein breites Spektrum der De-pressivität ab, wodurch das BDI-II als Gesamtes im Bereich durchschnittlicher bis ausgeprägter Depressivität eine sehr hohe Reliabilität erreichte. Das Item ‚Wertlosigkeit‘ konnte hierbei am besten, das Item ‚Appetitveränderung‘ am schlechtesten diskriminieren. Während sich für ‘Weinen’ geschlechtsabhängig signifikant unterschiedliches Antwortverhalten – jedoch ohne signifikanten Einfluss auf den Testscore – abzeichnete, zeigten sich bzgl. des Alters keine derartigen Hinweise.
description: The study´s objective was to evaluate central psychometric properties of the revised version of the german Beck Depression Inventory (BDI-II) through the framework of Item Response Theory (IRT). Therefore the study performed a structured assessment of the general IRT model fit in a non-clinical sample (n=2419), a stepwise analysis of IRT based psychometric properties of BDI-II and an investigation of potential differential item functioning (DIF) by age and gender. Findings suggest, that the symptom ‚worthlessness‘ was the strongest, whereas ‚changes in appetite‘ was the lowest discriminating indicator. The severity parameters of all items embrased a broad range along the symptomatic continuum of depression. In general, BDI-II could reliably detect depressive manifestation in a wide range from normal to severe. While the item ‚crying‘ was flagged for DIF by gender – eventhough the global weight of DIF on the total test score was negligible – the items showed no evidenve of DIF by age.
Trichromatic Open Digraphs for Understanding Qubits
Creators: name: Lang, Alex
name: Coecke, Bob
Publisher: name: arXiv
Year: 2011
Subjects: subject: Category Theory (math.CT)
subject: Logic in Computer Science (cs.LO)
subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We introduce a trichromatic graphical calculus for quantum computing. The generators represent three complementary observables that are treated on equal footing, hence reflecting the symmetries of the Bloch sphere. We derive the Euler angle decomposition of the Hadamard gate within it as well as the so-called supplementary relationships, which are valid equations for qubits that were not derivable within Z/X-calculus of Coecke and Duncan. More specifically, we have: dichromatic Z/X-calculus + Euler angle decomposition of the Hadamard gate = trichromatic calculus.
description: In Proceedings QPL 2011, arXiv:1210.0298
Race, socioeconomic status, and autonomy support in the classroom
Creators: name: Gonzalez, Melanie Shanae
name: 0000-0003-0740-5740
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Autonomy
Racial bias
Socioeconomic bias
Teachers

description: Autonomy-supportive teaching practices are effective at improving the quality of students’ motivation and engagement. However, little is known about whether teachers employ autonomy-supportive practices equitably with students from different social groups. Through three national studies, this dissertation aims to investigate whether and why U.S. teachers might be biased against offering autonomy support to Black students and low-socioeconomic status (SES) students. The first study examines the joint causal effect that student race and SES have on adults’ likelihood of offering autonomy-supportive rationales for completing class activities. The second study examines how teachers’ likelihood of self-generating autonomy-supportive rationales covaries with their own students’ racial and socioeconomic composition. The third study extends the first by a) investigating the unique causal effects of student race and student SES, and b) exploring psychological mediators of these effects. Together, these three studies aim to highlight potentially consequential group disparities in students’ receipt of support for autonomy and provide an account of why biases in autonomy-supportive teaching might emerge.
Neue Strategien für den Einsatz von Betulinsäurederivaten in zwei unterschiedlichen Tumorentitäten
Creators: name: Funtan, Anne
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 540

description: In dieser Arbeit soll durch Modifizierung von Betulin und Betulinsäure (BS) ein Konzept entwickelt werden, mit welchen zwei unabhängige Tumorentitäten bearbeitet werden können. Im ersten Teil wurden zunächst unterschiedliche Carboanhydraseinhibitoren synthetisiert und charakterisiert. Alle neuen Verbindungen wurden einer zytotoxischen Untersuchung unterzogen. Für eine Bestätigung der CA-Inhibierung, wurde ein Enzym-Kinetik-Assay etabliert. Ein zweiter wichtiger Ansatzpunkt ist die Entwicklung topischer Applikationsmöglichkeiten für die gezielte äußerliche Behandlung von Hauttumoren. Hierbei lag das Ziel in der biologischen Evaluierung potentieller Wirkstoffe, um in einem zweiten Schritt eine topische Formulierung zur Behandlung von equinen Melanomen entwickeln zu können. Eine weiter wichtige Einschätzung lieferte die Untersuchung der Zelltodmechanismen. Aufgrund der guten Verfügbarkeit und überzeugenden Wirkung, wurden BS und NVX-207 für alle nachfolgenden Untersuchungen verwendet.
description: In this work, a concept is developed by modification of betulin and betulinic acid (BS), with which two independent tumor entities can be treated. In the first part, different carbonic anhydrase inhibitors were synthesized and characterized. All new compounds were subjected to cytotoxic assays. To confirm the CA inhibition, an enzyme kinetics assay was established. A second important starting point was the development of topical application options for the targeted external treatment of skin tumors. Here, the goal was the biological evaluation of potential active ingredients in order to be able to develop a topical formulation for the treatment of equine melanomas in a second step. Another important assessment was the investigation of cell death mechanisms. Due to their good availability and convincing efficacy y, BS and NVX-207 were used for all subsequent studies.
Additional file 3 of Degradome sequencing reveals an integrative miRNA-mediated gene interaction network regulating rice seed vigor
Creators: name: Zhou, Shiqi
name: Huang, Kerui
name: Zhou, Yan
name: Hu, Yingqian
name: Xiao, Yuchao
name: Chen, Ting
name: Yin, Mengqi
name: Liu, Yan
name: Xu, Mengliang
name: Jiang, Xiaocheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S4. The prediction of subcellular distributions and proportions of proteins encoded by miRNA target genes corresponding to the degradome transcripts. The value in the outer circle represents the percentage of the number of degradome transcripts of each category, the value in the inner circle represents the number of degradome transcripts of each category.
Standard sulla competenza informativa per gli studi universitari
Creators: name: College, The Association Of
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2000
Subjects: M-STO/08 Archivistica, bibliografia e biblioteconomia

description: Questo documento è la traduzione italiana degli "Standard sulla competenza informativa per gli studi universitari" ("Information Literacy Competency Standards for Higher Education") emanati dalla Association of College and Research Libraries dell'ALA. Per competenza informativa si intende quell'insieme di abilità che vengono richieste agli individui "per riconoscere quando è necessario reperire informazioni, e per essere capaci di localizzare, valutare e utilizzare efficacemente l'informazione necessaria". La competenza informativa sta diventando sempre più importante nell'attuale contesto di rapidi cambiamenti tecnologici e di continua proliferazione di risorse informative. La competenza informativa costituisce la base dell'educazione permanente: è comune a tutte le discipline, a tutti gli ambienti d'apprendimento, ad ogni livello d'istruzione; è ciò che pone in grado coloro che apprendono di padroneggiare i contenuti e di ampliare le proprie ricerche, di diventare più autonomi e di assumere il controllo sul proprio apprendimento.
Unlearning Religion
Creators: name: Schulze, Alexander
Publisher: name: International Academy of Practical Theology. Conference Series
Year: 2021

description: When South West Africa was placed on the agenda of the UN General Assembly as the first decolonization case, no one could foresee that Namibia would be one of the last independent territories of the world. While the political decolonization of most of the former colonies was essentially completed in the mid-1970s, on May 4th, 1978 the SWAPO (South West African People's Organization) suffered its biggest military setback so far. As a result of the attack on the Kassinga refugee camp, between 1979 and 1989 a total of 423 children were brought to the GDR (German Democratic Republic). Experiencing their childhood and youth in the safe socialist state, they were educated according to the ideals of the SWAPO and the curricula of the GDR in order to become the elite of the new Namibia. Religion was not taught and largely suppressed. After their sudden repatriation to independent Namibia in 1990, the “GDR children” felt like strangers in their own country. Despite their good education, they were denied the opportunity to make a significant contribution to the development of the young country. Left alone and disappointed by the promises of the SWAPO, the churches began to play an unexpected role in the lives of the “GDR children”. So it became possible to link to early childhood and henceforth suppressed religious imprints. This article analyzes the religious practices of the “GDR children from Namibia”. Based on the data available so far, the role of the churches can be described as ambivalent. By filling the vacuum, the churches made it possible to reintegrate the “GDR children” into the existing system. In the medium term, however, they indirectly contributed to leveling out their unique competencies. The potential of the “GDR children” for the decoloniality process of independent Namibia was not recognized.
description: International Academy of Practical Theology. Conference Series, Vol 2 (2021): (De)coloniality and religious practices: liberating hope; edited by Valburga Schmiedt Streck, Júlio Cézar Adam and Cláudio Carvalhaes
The Dominance of Neutrino-Driven Convection in Core-Collapse Supernovae
Creators: name: Murphy, Jeremiah W.
name: Dolence, Joshua C.
name: Burrows, Adam
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Multi-dimensional instabilities have become an important ingredient in core-collapse supernova (CCSN) theory. Therefore, it is necessary to understand the driving mechanism of the dominant instability. We compare our parameterized three-dimensional CCSN simulations with other buoyancy-driven simulations and propose scaling relations for neutrino-driven convection. Through these comparisons, we infer that buoyancy-driven convection dominates post-shock turbulence in our simulations. In support of this inference, we present four major results. First, the convective fluxes and kinetic energies in the neutrino-heated region are consistent with expectations of buoyancy-driven convection. Second, the convective flux is positive where buoyancy actively drives convection, and the radial and tangential components of the kinetic energy are in rough equipartition (i.e. K_r ~ K_θ + K_ϕ). Both results are natural consequences of buoyancy-driven convection, and are commonly observed in simulations of convection. Third, buoyant driving is balanced by turbulent dissipation. Fourth, the convective luminosity and turbulent dissipation scale with the driving neutrino power. In all, these four results suggest that in neutrino-driven explosions, the multi-dimensional motions are consistent with neutrino-driven convection.
description: Accepted by the Astrophysical Journal
The epidemiology of osteoarthritis and its association with cardiovascular disease and diabetes
Creators: name: Rahman, Md Mushfiqur
Publisher: name: University of British Columbia
Year: 2014

description: Background: Osteoarthritis (OA) is a highly prevalent chronic condition and the most common form of rheumatic disease. The relationship between OA and cardiovascular disease (CVD) and diabetes has not been observed prospectively and the data on descriptive epidemiology of administratively defined OA are limited. Objectives: 1) to determine whether OA increases the risk of CVD (myocardial infarction, ischemic heart disease, congestive heart failure, and stroke) and diabetes; 2) to examine the association between OA and prevalent CVD; 4) to estimate the prevalence, incidence, and trends of OA; and 5) to validate the administrative diagnosis of OA. Methods: Using a random sample (n = 640,000) from the British Columbia administrative database during the period 1991-2009, the crude and age-standardized incidence rates and the prevalence of OA were calculated. Administrative OA Definition 1 required at least one physician diagnosis or hospital admission, and Definition 2 required, at least two physician diagnoses in two years or one hospital admission. The relative risks (RR) of CVD and diabetes in persons with OA, compared to age-sex matched non-OA individuals, were estimated using Cox proportional hazards models. Based on the Canadian Community Health Survey (CCHS) data, odds ratio (OR) between OA and heart disease was obtained. The validity of the two administrative definitions was determined using four clinical reference standards. Results: The overall prevalence of OA on March 2009, was 19.7%, and the incidence rate in the year 2008/09 was 14.6/1000 person-years under Definition 1. The adjusted RRs (95% CI) for CVD were 1.26 (1.13-1.42), 1.17 (1.07-1.26), 1.08 (0.97-1.19), and 1.15 (1.04-1.27), among younger women, older women, younger men, and older men, respectively. For diabetes, adjusted RRs (95% CI) were 1.27 (1.18-1.38), 1.23 (1.12-1.34), 1.19 (1.09-1.29), and 0.94 (0.82-1.09) for younger women, older women, younger men, and older men, respectively. In the CCHS sample, ORs (95% CI) for heart disease were 1.35 (1.21-1.50) among men and 1.51 (1.39-1.64) among women. Conclusions: These novel findings update current knowledge of OA epidemiology and highlight the risks of CVD and diabetes among persons with OA. These data are useful in formulating public health policies around OA treatment and prevention.
Studiare, documentarsi, incontrarsi. Indagine sull'utenza delle biblioteche dell'Università di Bologna
Creators: name: Alma Mater Studiorum, Università Di Bologna
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2006
Subjects: M-STO/08 Archivistica, bibliografia e biblioteconomia
SECS-S/05 Statistica sociale

description: Nel 2004 il Sistema bibliotecario, in collaborazione con l'Osservatorio statistico, ha effettuato una rilevazione sulla soddisfazione degli utenti tramite questionario-intervista.

L'indagine è stata condotta nelle otto biblioteche centralizzate della sede di Bologna e in quattro delle maggiori biblioteche di dipartimento, una per ognuna delle aree disciplinari dello SBA (biosfera, scientifico-tecnica, sociale e umanistica). Allo scopo di raccogliere le valutazioni di un campione rappresentativo dell'utenza delle dodici biblioteche nel medesimo periodo di calendario, la rilevazione è stata interamente condotta nella settimana compresa fra il 22 ed il 26 novembre 2004.

Il questionario di indagine, predisposto dallo SBA, è stato somministrato e compilato direttamente dai rilevatori (intervista face to face). Complessivamente, sono state effettuate nei 5 giorni della rilevazione oltre 3.600 interviste, a fronte di un'utenza giornaliera che nelle biblioteche interessate è stimata prossima alle 2.400 unità.

I primi mesi del 2005 sono stati dedicati alla scannerizzazione delle schede raccolte, al successivo controllo e correzione dei risultati della lettura ottica, all'elaborazione ed alla produzione della documentazione statistica.

I risultati complessivi sono stati illustrati nel corso di una conferenza stampa il 20 maggio e sono raccolti in questo rapporto, mentre quelli relativi ad ogni singola biblioteca sono stati inviati ai responsabili della struttura.
Prädiktoren der Einstellung von Schülerinnen und Schülern zu Wildnis in Deutschland unter besonderer Berücksichtigung von Vorstellungen und Migrationshintergrund : kumulative Dissertation
Creators: name: Reinboth, Alma
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 910

description: In der vorliegenden kumulativen Promotion wurden im Rahmen von drei separaten Teilstudien die Einstellung zu Wildnis von Schülerinnen und Schülern sowie die potenziellen Einstellungs-prädiktoren der Wildnisvorstellung und des Migrationshintergrundes untersucht. Hierbei diente die erste quantitative Schülerbefragung (n1 = 280) der Validierung eines Erhe-bungsinstrumentes zur Erfassung der Einstellung zu Wildnis. Im Rahmen der zweiten Erhebung (n2 = 266) erfolgte eine deskriptive Beschreibung von Wildniseinstellungen und -vorstellungen sowie ein Nachweis des prädiktiven Einflusses der Vorstellung von Wildnis auf die Einstellung zu Wildnis. In der dritten Fragebogenerhebung (n3 = 1356) zeigten sich hauptsächlich signifi-kante Einstellungs- und Vorstellungsunterschiede zwischen Personen ohne Migrationshinter-grund sowie Personen mit eigenen Migrationserfahrungen oder zwei Elternteilen mit einem Migrationshintergrund. Im Rahmen einer Mediationsanalyse konnte zudem aufgezeigt werden, dass sich der Migrationshintergrund sowohl indirekt über die Vorstellung von Wildnis als auch direkt negativ auf die Einstellung zu Wildnis auswirkt.
description: In the present cumulative dissertation wilderness attitudes of students as well as the potential attitude predictors of wilderness perception and migratory background were assessed within the scope of three separate sub-studies. The first quantitative student survey (n1 = 280) served for the validation of the survey instru-ment about attitudes towards wilderness. In the scope of the second inquiry (n2 = 266) wilder-ness attitudes and perceptions of students were described and the predictive influence of wil-derness perceptions on wilderness attitudes was verified. The third inquiry (n3 = 1356) showed mainly significant differences in the attitudes and perceptions of persons without migrant back-ground and those who had personal migration experience or two parents with a migrant back-ground. Moreover, a mediation analysis could prove that the migrant background served on the one hand as a negative direct and on the other as a negative indirect attitude predictor via the wilderness perception.
Psectrocladius (Psectrocladius) oligosetus Wuelker 1956
Creators: name: Bitušík, Peter
name: Slobodníková, Veronika
name: Novikmec, Milan
name: Dudáš, Adam
name: Hamerlík, Ladislav
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Psectrocladius
Psectrocladius oligosetus

description: Psectrocladius (Psectrocladius) oligosetus Wuelker, 1956
Material examined.
• 26 pupal exuviae, Taul Hardau (R 3), 6 July 2023; 59 pupal exuviae, Taul Muced (R 12), 7 July 2023 • 1 pupal exuviae, Lake Gargalau 1 (R 7), 6 July 2023.
Distribution.
Palaearctic. Recorded from several European countries ranging from the south (Sicily) to the north (Scandinavia) and from the west (Ireland) to the eastern part of Russia (Ashe and O’Connor 2009).
Habitat.
Cold-stenothermic species occurring in lakes in mountain regions (e. g., Laville and Vinçon 1986, Bitušík et al. 2007, Boggero 2018), although Rieradevall et al. (2007) found it in intermittent mountain headstreams. The species shows an apparent affinity for low pH humic waters (e. g., Ruse 2002; Bitušík and Svitok 2006; Moller Pillot 2013; Bitušík et al. 2020).
Remarks.
This finding, along with an earlier record from Ukraine (Bitušík et al. 2020), partially fills the distribution gap of the species extending from the Baltic republics across Poland to the Balkans.
description: Published as part of Bitušík, Peter, Slobodníková, Veronika, Novikmec, Milan, Dudáš, Adam & Hamerlík, Ladislav, 2025, Chironomidae (Diptera) from mountain lakes of the Eastern Carpathians, Romania: First records and insight into diversity, pp. 107-123 in ZooKeys 1233 on pages 107-123, DOI: 10.3897/zookeys.1233.142856
Generation of induced pluripotent stem cells and their differentiation into microglia for the analysis of Alzheimer’s disease
Creators: name: Ehrhardt, Toni
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 572

description: Alzheimer (AD) ist die häufigste Ursache für Demenz bei älteren Menschen dessen Ursachen aus einem komplexen Zusammenspiel von genetischen Faktoren und Umweltfaktoren wirken. Mikroglia, die Immunzellen des Gehirns, sind involviert in die Schlüsselprozesse für die Akkumulation von Plaques. Genomweite Assoziationsstudien (GWAS) konnten DNA-Variationen identifizieren, die mit einem erhöhten Risiko für die AD assoziiert sind und nahelegen, dass das Immunsystem bei der Progression von AD eine wichtige Rolle spielt. Zum Untersuchen dieser Hypothese, wurden in dieser Arbeit induzierte pluripotente Stammzellen aus Patienten generiert und ein Protokoll zur Mikroglia Differenzierung etabliert. Ergebnisse der funktionellen Analysen wie der Motilität, Zytokinfreisetzung und Zellaktivierung sowie einer anschließenden Proteomanalyse brachten neue Erkenntnisse zu relevanten molekularen Mechanismen, welche die aus der GWAS abgeleiteten Hypothese zur Beteiligung des Immunsystem an der AD verifiziert.
description: Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is caused by a complex interaction of genetic and environmental factors. Microglia, the immune cells of the brain, are involved in key processes for plaque accumulation. Genome-wide association studies (GWAS) have been able to identify DNA variations associated with increased risk for AD, suggesting that the immune system plays an important role in AD progression. To investigate this hypothesis, this work generated induced pluripotent stem cells from patients and established a protocol for microglia differentiation. Results of functional analyses such as motility, cytokine release, and cell activation, as well as a subsequent proteomic analysis, provided new insights into relevant molecular mechanisms that verified the hypothesis derived from GWAS on the involvement of the immune system in AD.
Additional file 4 of Degradome sequencing reveals an integrative miRNA-mediated gene interaction network regulating rice seed vigor
Creators: name: Zhou, Shiqi
name: Huang, Kerui
name: Zhou, Yan
name: Hu, Yingqian
name: Xiao, Yuchao
name: Chen, Ting
name: Yin, Mengqi
name: Liu, Yan
name: Xu, Mengliang
name: Jiang, Xiaocheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S5. Source data for Fig. 9A.
Risk Premia and Optimal Liquidation of Credit Derivatives
Creators: name: Leung, Tim
name: Liu, Peng
Publisher: name: arXiv
Year: 2011
Subjects: subject: Pricing of Securities (q-fin.PR)
subject: Risk Management (q-fin.RM)
subject: Trading and Market Microstructure (q-fin.TR)
subject: FOS: Economics and business

description: This paper studies the optimal timing to liquidate credit derivatives in a general intensity-based credit risk model under stochastic interest rate. We incorporate the potential price discrepancy between the market and investors, which is characterized by risk-neutral valuation under different default risk premia specifications. We quantify the value of optimally timing to sell through the concept of delayed liquidation premium, and analyze the associated probabilistic representation and variational inequality. We illustrate the optimal liquidation policy for both single-named and multi-named credit derivatives. Our model is extended to study the sequential buying and selling problem with and without short-sale constraint.
description: 30 pages
title: Ein einfaches weich strukturvariables Anti-Windup
Creators: name: Ortseifen, Andreas
name: Adamy, Jürgen
Publisher: name: De Gruyter
Year: 2021

description: Dieser Beitrag stellt eine neue, nichtlineare Anti-Windup-Maßnahme für lineare Systeme vor, die auf der weich strukturvariablen Zustandsregelung mittels impliziter Ljapunov-Funktionen basiert. Durch die variable Struktur des Anti-Windup (AW) kann zum einen die Regelgüte im Vergleich zu linearen AW-Ansätzen beträchtlich gesteigert werden. Der Vorteil gegenüber existierenden strukturvariablen AW-Strategien ist zum anderen ein geringerer Entwurfsaufwand und eine einfacher zu implementierende Regelstrategie bei gleicher Regelgüte, wie anhand eines Beispiel demonstriert wird.