Additional file 1 of Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies
Creators: name: Gou, Wanglong
name: Wang, Huijun
name: Tang, Xin-yi
name: He, Yan
name: Su, Chang
name: Zhang, Jiguo
name: Sun, Ting-yu
name: Jiang, Zengliang
name: Miao, Zelei
name: Fu, Yuanqing
name: Zhao, Hui
name: Chen, Yu-ming
name: Zhang, Bing
name: Zhou, Hongwei
name: Zheng, Ju-Sheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 1: Supplementary methods. Fig. S1. Flow diagram of participants selection process. Fig. S2. Associations of famine exposure with gut microbial diversity. Fig. S3. Association of Observed OTUs with type 2 diabetes. Fig. S4. Association of in utero famine exposed with gut microbial diversity in the three cohorts. Fig. S5. Association of famine exposure with gut microbial diversity after age balance. Fig. S6. Shifts in the principal components of the microbial variation relative to the no-exposed control group. Fig. S7. Co-abundance network construction and keystone taxa identification in the GNHS cohort. Fig. S8. Co-abundance network construction and keystone taxa identification in the GGMP cohort. Fig. S9. Co-abundance network construction and keystone taxa identification in the CHNS cohort. Fig. S10. Mean relative abundance of keystone taxa in the three cohorts. Fig. S11. Association of keystone taxa with type 2 diabetes. Fig. S12. Association of early-life famine exposure with keystone taxa. Table S1. Characteristics of the participants included in the GNHS cohort. Table S2. Characteristics of the participants included in the GGMP cohort. Table S3. Characteristics of the participants included in the CHNS cohort. Table S4. Association of famine exposure with gut microbial diversity in the GNHS cohort (Model 1). Table S5. Association of famine exposure with gut microbial diversity in the GGMP cohort (Model 1). Table S6. Association of famine exposure with gut microbial diversity in the CHNS cohort (Model 1). Table S7. Association of famine exposure with gut microbial diversity in the GNHS cohort (Model 2). Table S8. Association of famine exposure with gut microbial diversity in the GGMP cohort (Model 2). Table S9. Association of famine exposure with gut microbial diversity in the CHNS cohort (Model 2). Table S10. Association of famine exposure with gut microbial diversity in the GNHS cohort (Model 3). Table S11. Association of famine exposure with gut microbial diversity in the GGMP cohort (Model 3). Table S12. Association of famine exposure with gut microbial diversity in the CHNS cohort (Model 3). Table S13. Association of famine exposure with gut microbial diversity in the GGMP cohort (Model 4). Table S14. Association of famine exposure with gut microbial diversity in the CHNS cohort (Model 4). Table S15. Association of in utero famine exposed with gut microbial diversity in the three cohorts. Table S16. Association of famine exposure with gut microbial diversity after age balance. Table S17. Shifts in the gut microbial composition relative to the no-exposed control group in the three cohorts.