cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spectroscopic investigation of Bovine Liver Catalase interactions with a novel phen-imidazole derivative of platinum
Creators: name: Roohollah Ghobadi
name: Adeleh Divsalar
name: Harifi-Mood, Ali Reza
name: Saboury, Ali Akbar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Successful clinical experience of using cisplatin and its derivatives in cancer therapy has encouraged scientists to synthesize new metal complexes with the aim of interacting with special targets such as proteins In this regard, biological effects of [Pt(FIP)(Phen)](NO3)2 compound which contains a novel phen-imidazole ligand, FIP, was investigated on bovine liver catalase (BLC) structure and function. Various spectroscopic methods such as UV–visible, fluorescence, and circular dichroism (CD) were applied at two temperatures 25 and 37°C for kinetics and structural studies. As a consequence, the enzymatic activity decreased slightly with increasing the platinum compound’s concentration up to 30 μM and then remained constant at near 80% after this concentration. On the other hand, the fluorescence quenching measurements revealed that despite slight changes in activity, catalase experiences notable alterations in three-dimensional environment around the chromophores of the enzyme structure with increasing platinum complex concentration. Moreover, quenching data showed that BLC has two binding sites for Pt complex and hydrogen bonding interactions play a major role in the binding process. Furthermore, CD spectroscopy data showed that Pt(II) complex induces significant decrease in α-helix content of the secondary structure of BLC, but notable increase in random coil proportion accompanying a slight decrease in β-sheet content. All in all, hydrogen bonding interactions which are mainly involved in the binding process of the novel phen-imidazole compound to BLC significantly alter the protein structure but slightly change its function. This might be a promising outcome for chemotherapists and medicinal chemists to investigate in vivo properties of this novel metal complex with significant binding tendency to a macromolecule in the low concentrations without decreasing its intrinsic function.
Molecular dynamics simulation and molecular docking studies of 1,4-Dihydropyridines as P-glycoprotein’s allosteric inhibitors
Creators: name: Omolbanin Shahraki
name: Zargari, Farshid
name: Najmeh Edraki
name: Khoshneviszadeh, Mehdi
name: Omidreza Firuzi
name: Miri, Ramin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: P-glycoprotein (P-gp) is a main factor contributing to multidrug resistance. The effect of this transporter protein on limiting the effectiveness of chemotherapy has been shown by various studies. In a previous report, we synthesized some 14-dihydropyridine (DHP) derivatives as inhibitors of human P-gp. In the present study, a computational approach has been exploited to reveal the main interactions between DHPs and P-gp. In order to do this, homology modeling was performed to obtain a model of the protein. Then, molecular dynamics simulation was used to refine the constructed model of P-gp in the presence of the lipids bilayer. Model validation was performed with several tools. Finally, molecular docking followed by MD simulation of ligand–protein complex was employed to elucidate the binding mode and the dynamical changes of protein with/without DHPs bound. The results emphasized that interaction of the residues Gln912, Ser909, Arg905, Ser474, Val472 with DHPs play a crucial role in the inhibitory of these ligands and this was in a relatively good accordance with the results reported in the experimental studies.
Il Vincenzo che c'è in me! Un viaggio con vela alla scoperta della Svizzera
Creators: name: Gerosa, Nina
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020
Subjects: Vincenzo Vela – patrimonio storico e culturale – museo – educazione civica – Svizzera – fonti storiche

description: La tesi di bachelor mira all’esplorazione e all’evoluzione dell’apprendimento scolastico del bambino in relazione al patrimonio storico culturale del territorio. Lo scopo di questa ricerca è quello di capire in che modo la vicinanza e le lezioni proposte a contatto con un patrimonio storico culturale del territorio (Museo Vela di Ligornetto) favorisca positivamente l’apprendimento e la motivazione nell’allievo e lo responsabilizzi nell’importanza del museo e della sua conservazione. Al Museo sono state progettate due giornate, riprese poi, su più lezioni in classe. Una prima infarinatura di educazione civica del nostro territorio nazionale. Gli attori di questa ricerca sono 16 allievi di quinta elementare. I dati sono stati raccolti per mezzo di questionari, grazie ai quali si sono potute raccogliere le percezioni dei bambini relative al patrimonio storico; all’influenza che ha sul loro apprendimento scolastico, sulla motivazione e sulla responsabilità nei confronti del museo e della sua conservazione. Purtroppo a causa del Coronavirus, non è stato possibile portare a termine l’itinerario e rispondere in modo esaustivo alle domande di ricerca. Dall’analisi dei dati raccolti è emerso che l’apprendimento, la motivazione, l’attenzione e la partecipazione alla costruzione del proprio sapere nell’allievo, sono favoriti in modo considerevole da una didattica incentrata sulla valorizzazione del patrimonio culturale. Relatrice: Sonia Castro Mallamaci.
title: OFROM: interview avec ilcf22a04
Creators: name: Delafontaine, François
name: RadioFribourg
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a5875uzq.v2#887da58d736c75d2649877d3243e41748dbd60bb
Progettazione ed analisi CFD di un innovativo scambiatore di calore a piastre per applicazioni ad alta temperatura
Creators: name: Centazzo, Davide
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020

description: Il seguente progetto propone lo studio e l’analisi di uno scambiatore di calore a piastre in materiale ceramico da utilizzare per preriscaldare l’azoto in ingresso all’impianto di water splitting ideato nell’ambito del progetto Hydrosol. A causa delle particolari condizioni di lavoro nel reattore la temperatura massima a cui dovrà resistere il componente arriverà a 1200 °C. Per tali ragioni l’intero scambiatore sarà composto da carburo di silicio e da studi preliminari è stato dimostrato che dovrà essere del tipo a piastre. Nella fase di progettazione si è valutato il design possibile ed è stato scelto un modello con entrambi i collettori interni e un tipo di alettatura basato sul concetto di offset strip fin, successivamente tramite un modello semplificato 1D sono state valutate le dimensioni del Core in termini di numero di piastre e geometria. I risultati ottenuti hanno indicato come lo scambiatore per ottenere un risultato vicino all’efficacia di 0,92 debba essere costruito da 20 piastre in grado complessivamente di garantire un’efficacia di 0,88. Una volta ottenuti i primi risultati ci si è concentrati sulla scelta e la geometria dei collettori, non avendo a disposizione correlazioni matematiche valide per il loro dimensionamento si è cercato di minimizzare la velocità dei gas nell’impianto. Il risultato ottenuto è stata una velocità massima predetta di ci circa 7,7 m/s mentre per quanto concerne la parte di core grazie al modello semplificato viene definita una velocità media di 1,8 m/s. Una volta in possesso di questi risultati viene definita la geometria dello scambiatore grazie ad un modello CAD di cui sono disponibili anche le messe in tavola. Durante tale fase sono stati fissate le dimensioni esterne e il modo con cui verrà connesso lo scambiatore all’impianto. Nell’ultima fase si è impostata un’analisi CFD che ha portato alla generazione di un mesh strutturata, sulla geometria semplificata dello scambiatore, di circa 5 milioni di elementi e alla successiva definizione dei parametri in Fluent in cui le alette sono state simulate grazie all’utilizzo di un mezzo poroso definito mediante correlazioni teoriche presenti in letteratura e alle impostazioni disponibili presenti nel software. A causa di errori e ritardi nell’impostazione del calcolo non è stato possibile avere a disposizione un modello computazionale completo dello scambiatore tuttavia è stato possibile definire adeguatamente il mezzo poroso atto a simulare l’alettatura e utilizzando un caso semplificato trarre alcune conclusioni in particolare sui miglioramenti di alcune zone problematiche della geometria che causano distacchi di vena e velocità eccessivamente elevate in alcune settori dello scambiatore. Complessivamente lo scambiatore è composto da 20 piastre ha un’efficacia teorica 0,88 vicino all’obbiettivo di 0,92 necessaria a ottenere la temperatura di uscita di 1150°C, presenta un’altezza di 540 mm e un peso di 270 kg
Catturare l'ascolto: lo studio dei suoni ambientali nel contesto del paesaggio sonoro come strumento per migliorare le capacità di attenzione degli studenti della scuola media
Creators: name: Rosini, Sylwia Anna
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2024
Subjects: educazione musicale
paesaggi sonori
paesaggi sonori e sviluppo dell’attenzione
educazione musicale alla scuola media

description: Questa tesi si concentra sull'analisi dell'attenzione degli studenti della scuola media nel contesto del paesaggio sonoro durante le lezioni di educazione musicale. Attraverso l'osservazione dei comportamenti di adolescenti in età compresa tra gli undici e i dodici anni, si esplora l'effetto dell'esposizione al paesaggio sonoro sullo sviluppo delle capacità di attenzione. La metodologia comprende un'indagine qualitativa di osservazione sul campo, composta da una serie di attività di ascolto attivo in classe e da due passeggiate sonore, rispettivamente in entrata e in uscita, con un’analisi dei dati, che si focalizza sulle variazioni dell’attenzione prima, durante e dopo lo svolgimento delle attività. I risultati suggeriscono la conferma dell’ipotesi in cui si presupponeva che lo studio dei paesaggi sonori potesse contribuire allo sviluppo dell’attenzione nei ragazzi di scuola media e forniscono nuove prospettive nel campo dell'utilizzo delle attività di educazione musicale come strumenti per lo sviluppo delle competenze negli ambiti della formazione generale e delle competenze trasversali. Relatrice: Anna Galassetti.
The motivation and impact of outward foreign direct investment in China
Creators: name: Pun, Chi Chung
Publisher: name: Lancaster University
Year: 2020
Subjects: China
Outward foreign direct investment
multinational firms

description: The Chinese government believed that encouraging the country’s enterprises to invest overseas would strengthen the competitiveness of domestic firms, which would, in turn, promote Chinese economic growth. However, according to theory, the Chinese firms investing overseas would require certain firm-specific advantages which they would use as leverage during the internationalisation process. Herein lies the problem, Chinese enterprises have been often perceived as lacking specific strengths. This thesis includes three empirical studies, which aim to explore the latest developments of Chinese outward foreign direct investment by investigating how Chinese enterprises acquire crucial firm-specific advantages and understand the consequence towards the local economy. The first contribution of this study focuses on Chinese investments in 34 OECD countries, with the aim of identifying the key determinants of outward investment. The work details an examination of the validity of a wide range of factors believed to underpin the motivation driving foreign direct investment. The second empirical study aims to understand the motivations of investing into Hong Kong SAR by conducting a firm level study through a survey and interviews. The results indicate the Chinese enterprises expect to add value by investing in Hong Kong SAR, where a platform is provided for equipping firm-specific advantages that may speed up the progress of internationalisation. The third empirical study evaluates the impact of Chinese outward foreign direct investment on the home economy from productivity perspectives. The findings on productivity indicate a positive impact of outward foreign direct investment on total productivity factors and provide evidence to indicate success in the catching up effect in China. The results obtained by studying the motivations of Chinese overseas investments and the impact of the investments on the local economy may encourage further studies in the area. More importantly, the significant findings have important managerial and government policy implications.
La competenza diagnostica del docente di educazione fisica
Creators: name: Cereghetti, Steven
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020

description: Il presente lavoro di ricerca, incentrato sulla competenza diagnostica dei docenti di educazione fisica, ha cercato di analizzare l’accuratezza dei docenti nel diagnosticare le competenze motorie di base degli allievi, divise nelle componenti “muoversi” e “muovere oggetti” e utilizzando il test MOBAK 1-2. Allo studio hanno partecipato cinque docenti di educazione fisica (età media = 27 ± 1 anni), i quali hanno inizialmente stimato i risultati dei loro allievi (n = 75, età media 6.6 ± 0.5 anni) di prima SE del test MOBAK. I docenti hanno poi effettuato un test reale dei loro allievi, utilizzando le prove contenute nel MOBAK 1-2, hanno completato una breve autovalutazione e risposto a domande anagrafiche di base. I risultati mostrano che il giudizio diagnostico dei docenti per la componente “muovere oggetti” è accurato. Un’analisi granulare rivela diverse sotto e sopravvalutazioni per la componente di livello. Si riscontra una leggera sottostima della componente di differenziazione. L’analisi del background ha mostrato che i docenti con esperienza professionale sociomotoria hanno un giudizio più accurato per la componente “muovere oggetti”. La presente ricerca ha sottolineato l’importanza di ulteriori approfondimenti con un campione più elevato di allievi, data anche la scarsità della letteratura in questo ambito specifico. Relatore: Giacomo Crivelli. Materia: Educazione fisica.
Security Challenges Facing the Internet of Things in Academic Libraries
Creators: name: Alluhaybi, Essa Hamed
Publisher: name: Zenodo
Year: 2021
Subjects: : Internet of Things, Academic Libraries, IoT, Security, Vulnerability, Threat Words count: 3138 words

description: Internet of Things (IoT) is a term used to conceptualise an idea of a network of connected devices communicating with each other over the internet. While IoT has presented humans with substantial scopes of convenience in the service industry, there liesinherent vulnerabilities and threats in IoT infrastructures that present security challenges. The security challenges of using IoTs in academic libraries are discussed in this paper. The 4-layered IoT architecture is presented, and vulnerabilities in each layer are discussed. The challenges are those that are inherent from sensory devices such as RFID, WSNs, barcodes, and scanners. The security challenges of IoT in academic libraries threaten the expectation of privacy of students, faculty members and university staff. The security challenges also present large financial risks to the institution and its affiliates. Non-technical, socially engineered attacks are also a security challenge to IoTs in academic libraries with grave implications to personal security of its patrons. The implications of IoT vulnerabilities for academic libraries are presented, and recommendations are made to address the security challenges of using IoTs in academic libraries.
title: OFROM: interview avec ilcf22a03
Creators: name: Delafontaine, François
name: Mariéthoz, Sarah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.3ced9178.v2#c48954b4ce26a683df926db644a853d366faa1c4
The Impact of Applying Artificial Intelligence on the Quality of Enterprises Decision-Making
Creators: name: Alluhaybi, Essa Hamed
Publisher: name: Zenodo
Year: 2021
Subjects: : artificial intelligence, machine learning, decision-making, quality of enterprises, digital competitors - e-commerce – marketing, PRIZMA.

description: Artificial Intelligence (AI) is becoming more heavily utilised in enterprise decision-making process, and it is being speculated that AI is on course to becoming capable of fully supporting autonomous decision-making. However, there are significant, nonreplicable, human elements in a decision-making process, which are inherently absent in AI systems. This raises the question of the extent to which AI is able to support decision-making in its current form. AI has been heavily researched in the literature, but its role in enterprise decision making have only been very recently realised. It is important to realise where AI assisted decision-making process stands today. Most of the research conducted on AI decisionsupport systems have focused on the possibilities, opportunities, and challenges of being integrated into an enterprise decision-making process. What is lacking in the literature is an aggregate of the findings so that future research directions and investment opportunities can be better explored. In order to fill this gap, this research qualitatively analyses the very recent existing literature on AI’s contribution to enterprise decision-making process. The methodology applied is secondary data analysis in the form of a literature review conducted using the PRISMA method. Seminal research papers have been reviewed, and their findings analysed and aggregated. The findings indicate that AI is most utilised in data processing as this requires little input from humans other than feeding large, fast-paced, real-time data. The findings further show that beyond the decision-making process, AI is used in market prediction, and in healthcare enterprises for making medical oriented decisions. Finally, the most common AI algorithms that are utilised to help in enterprise decision-making process are artificial neural networks and swarm intelligence. Based on the findings, this research also suggests future research implications for academics.
Coupled molecular dynamics and continuum electrostatic method to compute the ionization pKa’s of proteins as a function of pH. Test on a large set of proteins
Creators: name: Vorobjev, Yury N.
name: Scheraga, Harold A.
name: Vila, Jorge A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: A computational method, to predict the pKa values of the ionizable residues Asp, Glu, His, Tyr, and Lys of proteins, is presented here. Calculation of the electrostatic free-energy of the proteins is based on an efficient version of a continuum dielectric electrostatic model. The conformational flexibility of the protein is taken into account by carrying out molecular dynamics simulations of 10 ns in implicit water. The accuracy of the proposed method of calculation of pKa values is estimated from a test set of experimental pKa data for 297 ionizable residues from 34 proteins. The pKa-prediction test shows that, on average, 57, 86, and 95% of all predictions have an error lower than 0.5, 1.0, and 1.5 pKa units, respectively. This work contributes to our general understanding of the importance of protein flexibility for an accurate computation of pKa, providing critical insight about the significance of the multiple neutral states of acid and histidine residues for pKa-prediction, and may spur significant progress in our effort to develop a fast and accurate electrostatic-based method for pKa-predictions of proteins as a function of pH.
Additional file 1: Table S1. of Transcriptomic analysis of Pak Choi under acute ozone exposure revealed regulatory mechanism against ozone stress
Creators: name: Zhang, Lu
name: Xu, Bin
name: Wu, Tao
name: Wen, Mu-xuan
name: Fan, Lian-xue
name: Feng, Zhao-zhong
name: Paoletti, Elena
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Summary of sequences analysis and RNA-Seq data. (DOCX 17Â kb)
Unweighted Versus Weighted Estimation for the Multivariate Growth Curve Model Useful in the Analysis of Longitudinal Data
Creators: name: Halden, Cody
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2024
Subjects: Growth Curve Model
Longitudinal Data

description: Growth Curve Models (GCMs) are useful in analyzing longitudinal data or studies involving response curves. GCMs, a type of bilinear regression model, include within- and between individual design matrices. Assuming multivariate normality, explicit likelihood solutions exist, often optimal even for small samples. This thesis examines the estimation of mean parameters in GCMs, using simulations to compare unweighted and weighted estimators in various scenarios: large sample (n > p), near singularity (n ≈ p), and high-dimensional (n < p). Longitudinal data with different levels of within-individual correlations were considered, and estimators were compared based on bias and mean squared error (MSE). Matrix bias and matrix MSE aggregation methods were explored for comparative evaluations. Illustrations using three real datasets were provided. Simulation results showed unweighted estimators performed well in most scenarios, except with unstructured variance-covariance matrices. Unweighted estimators were more optimal for structured variance-covariance matrices, regardless of within-individual correlation strength. Further investigation is needed to evaluate weighted estimators in other covariance structures and assess robustness against model misfits and non-normality.
title: OFROM: interview avec ilcf22a02
Creators: name: Delafontaine, François
name: Mariéthoz, Sarah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.3fca8272.v2#b2eaa28ff33307a16f87bb8c2f3915ede25f6033
Progettazione di una cella robotica di assemblaggio di componenti elettronici
Creators: name: Borriello, Stefano
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2018

description: In questo progetto di diploma, viene progettata una cella robotica per automatizzare il processo d’avvitatura di bulloni M3. Tali componenti vengono adoperati per fissare componenti elettromeccanici ai pannelli degli ascensori della ditta Schindler Ascensori AG di Locarno. Attualmente il processo d’avvitatura dei bulloni M3 viene effettuato completamente da operatori. Nella progettazione della cella robotica viene svolta l’analisi del processo, per comprendere le problematiche dell’automazione del processo. Analizzando dimensioni, materiale e componenti che vengono o possono essere montati all’interno dei tre tipi di pannelli di ascensori. Nella progettazione della cella robotica è stato scelto un avvitatore automatico autoalimentato, adatto ad essere utilizzato con i robot della Universal Robots. La tipologia di robot è stata imposta dalla ditta Schindler Ascensori AG di Locarno, per il fatto che utilizzano già questa tipologia di robot. Sono stati selezionati tutti i componenti necessari per poter effettuare il processo d’avvitatura in sicurezza, entro gli spazi disponibili e considerando un’agibile manutenzione.
Unjuran Kemiskinan Melalui Imej Satelit di Sabah
Creators: name: Ating, Rashid
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390107
subject: Humanities and social sciences curriculum and pedagogy (excl. economics, business and management)
classificationCode: 460105
subject: Applications in social sciences and education

description: Penggunaan imej satelit sebagai kaedah penyelidikan dalam penulisan jurnal artikel bukanlah sesuatu yang baharu. Berdasarkan pangkalan data Web of Science (WoS) dan Scopus, iaitu dua pangkalan data yang paling dipercayai oleh para penyelidik untuk menerbitkan hasil penyelidikan mereka dalam bentuk journal artikel, kajian menggunakan kaedah ini telah bermula sejak tahun 2014 (menurut pangkalan data Scopus) dan tahun 2013 (menurut pangkalan data Web of Science). Kebanyakan kajian yang menggunakan imej satelit lebih tertumpu terhadap kajian sains komputer, kejuruteraan, sains alam sekitar, astronomi dan fizik (carian di pangkalan data Scopus), manakala teknologi sains alam sekitar, geologi, penderiaan jauh dan teknologi sains pengimejan (carian di pangkalan data Web of Science).
Supplementary material for Patterns of predicted mutation burden in 19778 domesticated barley accessions conserved ex situ
Creators: name: Fu, Yong-Bi
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310509
subject: Genomics

description: These are the supplemental files for the paper: Patterns of predicted mutation burden in 19778 domesticated barley accessions conserved ex situ, published in International Journal of Molecular Sciences (2024)
Data Justice in Practice: A Guide for Policymakers
Creators: name: Leslie, David
name: Katell, Michael
name: Aitken, Mhairi
name: Singh, Jatinder
name: Briggs, Morgan
name: Powell, Rosamund
name: Rincón, Cami
name: Perini, Antonella
name: Jayadeva, Smera
Publisher: name: Zenodo
Year: 2022
Subjects: data justice
digital rights
data ethics
AI ethics
social justice
power
access
equity
participation
knowledge
data power
digital infrastructure
human rights
data colonialism
decolonial AI
economic justice
data feminism
design justice
pluriverse
post-development theory
intercultural ethics
intercultural communication

description: The Advancing Data Justice Research and Practice project aims to broaden understanding of the social, historical, cultural, political, and economic forces that contribute to discrimination and inequity in contemporary ecologies of data collection, governance, and use. This is the consultation draft of a guide for policymakers. It provides actionable information for policymakers who wish to implement the principles and priorities of data justice in their policymaking activities. In the first section, we introduce the nascent field of data justice, from its early discussions to more recent proposals to relocate understandings of what data justice means. This section includes an account of the outreach we conducted with stakeholders throughout the world in developing a nuanced and pluralistic conception of data justice and concludes with a description of the six pillars of data justice around which this guidance revolves. Depending on their contexts, potential impacts, and scale, data policymaking activities may be carried out in a way that involves stakeholder engagement. To facilitate this process, the next section provides an explainer of the Stakeholder Engagement Process and the steps it includes—preliminary horizon scanning, policy scoping and stakeholder analysis, positionality reflection, and establishing stakeholder engagement objectives and methods. Finally, the last section presents the guiding questions that will help policymakers address issues of data, digital infrastructures, and affected areas of civic, public, and private life, throughout the policy lifecycle and in accordance with the six pillars of data justice.
description: This report was commissioned by the International Centre of Expertise in Montréal in collaboration with GPAI's Data Governance Working Group, and produced by the Alan Turing Institute. The research was supported, in part, by a grant from ESRC (ES/T007354/1), Towards Turing 2.0 under the EPSRC Grant EP/W037211/1, and from the public funds that make the Turing's Public Policy Programme possible.
Theoretical studies on the interaction between the nitrile-based inhibitors and the catalytic triad of Cathepsin K
Creators: name: C. Pitchumani Violet Mary
name: R. Shankar
name: S. Vijayakumar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology
subject: 60506 Virology

description: Computational studies on the interaction of novel inhibitor compounds with the Cathepsin K protease have been performed to study the inhibition properties of the inhibitor compounds. The quantum chemical calculations have been performed to analyze the molecular geometries, structural stability, reactivity, nature of interaction, and the charge transfer properties using B3LYP level of theory by implementing 6-311g(d,p) basis set. The calculated C–S and N–H…N bond lengths of the inhibitor-triad complexes are found to agree well with the previous literature results. The chemical reactivity of the inhibitors and catalytic triad are analyzed through frontier molecular orbital analysis and found that the inhibitors are subjected to nucleophilic attack by the catalytic triad. The nature of inhibition of the inhibitor compounds is examined using the quantum theory of Atoms in Molecules analysis and found to be partially covalent. The NBO stabilization energy for the Cys – inhibitor are found to be most stable than the other interactions. The molecular dynamic simulations were performed to study the influence of dynamic of the active site on the QM results. The many body decomposition interaction energy calculated for the final results of MD simulation reveals that the dynamic of the active site induces significant changes in the interaction energy and occupancy of H-bonds plays a major role in the stabilizing the active site inhibitor interactions. The present study reveals that the inhibitor compounds can inhibit the proteolytic activity of the proteases on binding with the catalytic active site.
Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles
Creators: name: Serçinoğlu, Onur
name: Pemra Ozbek
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Human major histocompatibility complex class I (MHC I) – or human leukocyte antigen (HLA) – proteins present intracellularly processed peptides to cytotoxic T lymphocytes in the adaptive immune response to pathogens. A high level of polymorphism in human MHC I proteins defines the peptide-binding specificity of thousands of different MHC alleles. However, polymorphism as well as the peptide ligand can also affect the global dynamics of the complex. In this study, we conducted classical molecular dynamics simulations of two HLA alleles, the ankylosing spondylitis (AS) associated/tapasin-dependent HLA-B*27:05 and nondisease-associated/tapasin-independent HLA-B*27:09, both in peptide-free forms as well as complex with four different peptides ligands. Our results indicate that in peptide-free form, the single amino acid substitution distinguishing the two alleles (D116H), leads to a weaker dynamic coupling of residues in the tapasin-dependent HLA-B*27:05. In peptide-bound form, several residues of the binding-groove, mostly in A and B pockets, show hinge-like behavior in the global motion of the MHC. Moreover, allele-dependent changes are shown in residue interactions, affecting the B-pocket as well as the beta-2-microglobulin (β2m)-facing residues of the HLA chain.
Additional file 1: Figure S1. of Diagnostic value of interleukins for tuberculous pleural effusion: a systematic review and meta-analysis
Creators: name: Zeng, Ni
name: Wan, Chun
name: Qin, Jiangyu
name: Wu, Yanqiu
name: Yang, Ting
name: Shen, Yongchun
name: Wen, Fuqiang
name: Chen, Lei
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Forest plot of the sensitivities and specificities reported by each interleukin. The Forest plots of the sensitivities and specificities reported by A. interleukin-6; B.interleukin-33; C interleukin-12; D interleukin-2; E interleukin-12p40. Figure S2. Funnel graph for the assessment of potential publication bias in each interleukin. The Funnel graphs for the assessment of potential publication bias in each interleukin: A for IL-27; B for IL-18;C for IL-6; D for IL-33; E for IL-12; F for IL-2; G for IL-12p40. (DOC 231Â kb)
Kreacje postaci bohatera (i antybohatera) prozy Ignacego Krasickiego na tle powieści oświeceniowej
Creators: name: Stasiewicz, Piotr Emil
Publisher: name: Zenodo
Year: 2017

description: The paper is an analysis of strategies of creating a protagonist in Ignacy Krasicki' novels in the context of hero and antihero categories. Krasicki's strategy is compared here with various aspects of 18th century novel with special emphasis on antiheroic narratives.
Il Rally Matematico per lo sviluppo dell’autonomia nel gruppo: un’esperienza di cooperative learning
Creators: name: Dos Santos Monteiro, Kelly
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2016

description: Il percorso realizzato attraverso questa sperimentazione didattica ha permesso di testare il “cooperative learning” all’interno di una classe di quinta elementare. Proporre attività finalizzate al miglioramento del lavoro di gruppo in autonomia per affrontare le due Prove del Rally Matematico Transalpino, ha permesso di scoprire quali delle cinque condizioni irrinunciabili relative al “cooperative learning” sarebbe stato opportuno andare a sviluppare. L’attenzione si è quindi riposta soprattutto sull’interdipendenza positiva, sulla responsabilità individuale e sull’interazione costruttiva, poiché gli aspetti legati alle abilità sociali e alla valutazione di gruppo apparivano pressoché acquisiti dalla classe. Per mezzo di un lavoro di ricerca di tipo qualitativo, che oltre all’osservazione prevedeva anche la somministrazione di uno stesso questionario all’inizio e alla fine del percorso, è stato possibile verificare quali strategie e quali atteggiamenti messi in atto avessero aiutato i bambini a lavorare in autonomia durante i lavori di gruppo e quali cambiamenti avessero apportato. Si è trattato di un itinerario molto arricchente, poiché oltre a consentire ai bambini di sviluppare un lavoro di gruppo sempre più autonomo, ha permesso di approfondire l’importanza di continuare a sperimentare questa modalità di lavoro anche negli anni avvenire, per stimolare gli allievi a diventare i principali autori delle loro conoscenze. Relatore: Davide Antognazza
title: From "Critique" to "Engagement through Experimentalism" Uncertainty as the Epistemic Basis of an Alternative Form of Critique
title: From "Critique" to "Engagement through Experimentalism" Uncertainty as the Epistemic Basis of an Alternative Form of Critique
titleType: AlternativeTitle
title: Von »Kritik« zu »Engagement durch Experimentalismus« Ungewissheit als epistemische Grundlage einer alternativen Kritikform
titleType: AlternativeTitle
Creators: name: Lehmann, Damaris
Publisher: name: Universitätsbibliothek Siegen
Year: 2021
Subjects: subject: Experimentalism+Pragmatism+STS+Science and Technology Studies+Sociology of Critique
subject: Experimentalism, Pragmatism, STS, Science and Technology Studies, Sociology of Critique

description: The thesis explores how sociology can adopt an experimental and pragmatic approach to critique by embracing uncertainty as an epistemological foundation. Through a deep engagement with the works of Dewey, Boltanski, and other sociologists, the research argues for a shift from classical critical sociology to an "experimentalism" that is inclusive of actors' reflexive abilities. This shift reimagines critique not as a top-down analytical tool, but as an interactive process rooted in the situational and contextual dynamics of everyday life. The work is structured around examining Dewey's pragmatist philosophy, emphasizing experience, reflexivity, and the rejection of fixed dualisms in understanding knowledge. It critiques traditional critical sociology’s focus on structural determinism, which often sidelines actors' agency, and instead advocates for a sociology that appreciates the dynamic, co-constructed nature of social order. In adopting an STS framework, the research leverages concepts like “epistemic modesty” and “situated knowledge,” aligning with the pragmatist emphasis on reflexivity and adaptability. STS contributes a nuanced understanding of how sociological critique can move beyond detached observation, integrating experimentalism as a method that not only observes but actively participates in shaping social realities. This approach repositions sociology as a participant within the fabric of societal issues, furthering the thesis’s call for a pragmatist, engaged sociology that is responsive to the shifting, technology-mediated landscapes of contemporary life.
Additional file 1: Table S1. of Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?
Creators: name: Hall, Michelle
name: Hinman, Rana
name: van der Esch, Martin
name: van der Leeden, Marike
name: Kasza, Jessica
name: Wrigley, Tim
name: Metcalf, Ben
name: Dobson, Fiona
name: Bennell, Kim
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Developmental Biology

description: Linear relationships between measure of peak isokinetic knee muscle strength (independent variable) and WOMAC physical function 100 scale (dependent variable), including interaction between ‘exercise program’ and ‘measure of strength’. (DOCX 20 kb)
Identification of dual kinase inhibitors of CK2 and GSK3β: combined qualitative and quantitative pharmacophore modeling approach
Creators: name: Triveni Pardhi
name: Vasu, Kamala
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: PTEN, a tumor suppressor protein, gets deactivated by casein kinase 2 (CK2) and glycogen synthase kinase 3β (GSK3β), which are the major causes of PI3K/AKT-driven tumors. To surmount this problem, the multi-target inhibitor strategy may be of great significance. The goal of this study was to design dual-target inhibitors of CK2 and GSK3β using a combination of pharmacophore modeling and molecular docking studies. The common feature-based (qualitative) and 3DQSAR-based (quantitative) pharmacophore models were generated and validated. The best pharmacophore models (Pharm18 and Hypo1) comprised two hydrogen-bond acceptors, one hydrophobic, and one ring aromatic features. The models were used to screen various chemical database and top mapped compounds from each database were selected. They were processed for Lipinski filter, Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis, and docking studies. We have obtained six hits with comparable dock score to the reported inhibitors. We have concluded Hit15 as a competent candidate based on its docking and Density Functional Theory (DFT) calculations. It showed 140.73 and 130.79 dock score in CK2 and GSK3β, respectively. The electronic property of Hit 15 showed the lowest energy gap (0.021) compared to other hits and active ligands which suggest its higher reactivity. In conclusion, this study may assist in the development of new potent dual kinase inhibitors of CK2 and GSK3β. Also, the overture effort of combined qualitative and quantitative modeling for the development of multi-target inhibitors may support the future endeavors.
title: OFROM: interview avec ilcf22a01
Creators: name: Delafontaine, François
name: Mariéthoz, Sarah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.aca0xyjb.v2#d405c537a8d5943fe313363aba1af1a5c916f456
Additional file 5: Table S2. of Transcriptomic analysis of Pak Choi under acute ozone exposure revealed regulatory mechanism against ozone stress
Creators: name: Zhang, Lu
name: Xu, Bin
name: Wu, Tao
name: Wen, Mu-xuan
name: Fan, Lian-xue
name: Feng, Zhao-zhong
name: Paoletti, Elena
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Ozone concentrations in non-filtered air (NF) and elevated ozone (E-O3) exposure. (DOCX 15Â kb)
Труды Кольского научного центра РАН, Выпуск 72020
Creators: name: Кольский научный центр Российской академии наук
Publisher: name: Труды Кольского научного центра РАН
Year: 2020

description: , Выпуск 72020
description: В 2010-м году президиум КНЦ РАН принял решение о возвращении к уже имевшейся в предыдущие годы практике издания «Трудов Кольского научного центра РАН» в виде специализированных тематических научных журналов по основным направлениям научно-исследовательской деятельности учреждений Центра.
title: 02_1554
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/