cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Carnet nº 13, commencé à Hiroshima (p. 43)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 31-10-1930
Breaking symmetry, breaking ground
Creators: name: Hindmarsh, Mark
Publisher: name: arXiv
Year: 2016
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: I give a short commentary on a seminal article by T W B Kibble in 1976, "Topology of cosmic domains and strings".
description: Published in J. Phys. A as part of a series of Viewpoints on 50 influential papers, celebrating the 50th anniversary of the Journal of Physics series. The article is dedicated to Tom, who died while it was being prepared
Local optical control of the resonant dipole-dipole interaction between Rydberg atoms
Creators: name: de Léséleuc, Sylvain
name: Barredo, Daniel
name: Lienhard, Vincent
name: Browaeys, Antoine
name: Lahaye, Thierry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on the local control of the transition frequency of a spin-$1/2$ encoded in two Rydberg levels of an individual atom by applying a state-selective light shift using an addressing beam. With this tool, we first study the spectrum of an elementary system of two spins, tuning it from a non-resonant to a resonant regime, where "bright" (superradiant) and "dark" (subradiant) states emerge. We observe the collective enhancement of the microwave coupling to the bright state. We then show that after preparing an initial single spin excitation and letting it hop due to the spin-exchange interaction, we can freeze the dynamics at will with the addressing laser, while preserving the coherence of the system. In the context of quantum simulation, this scheme opens exciting prospects for engineering inhomogeneous XY spin Hamiltonians or preparing spin-imbalanced initial states.
description: 5 pages, 3 figures
Estuarine sediment regimes, Far South Coast, N.S.W.
Creators: name: Kidd, Roderick William
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This dissertation presents the results of an integrated regional study of sediment exchanges between land and sea along a relatively unspoiled section of coastline in southern N.S.W. The regional climate is a temperate one with no seasonal moisture deficiency, while the shoreline is subject to a microtidal, high energy swell regime. Grainsize distribution, quartz roundness and sand mineralogy of sediments collected from fourteen rivers, their estuaries and the impounding barrier sands are analysed in order to determine the source(s) of local coastal sands. The factors and processes which control sediment distribution patterns in the three environments are also considered. Comparatively angular, poorly sorted river sands and gravels with significant proportions of non-quartz minerals are deposited at the heads of smaller estuaries as deltas. River mud accumulates on estuary floors as prodelta deposits or is flushed through the system and dispersed at sea. Estuary basin floors have been partly buried by landward prograding flood tide deltas whose sands are derived from the rounded, well sorted, predominantly quartzose sands which dominate most of the coastal embayments. Four estuaries have been infilled to the extent that terrigenous sands now travel through them to the sea. At two localities, advanced infilling reflects the dominance of fluvial activity, at another two, flood tide currents have performed the same role. Rates of terrigenous infilling are explained mainly by runoff and lithological characteristics of the drainage basins. Maximum infilling has occurred where large rivers drain granite catchments. Rates of infilling from seawards are greatest where inlet closure is least likely, a situation favoured by large tidal prisms, persistent stream flow and lower levels of incident wave power. In essence, most of the estuaries are sediment traps for both terrigenous and marine sands at the present time. Delivery of sand to the beaches from the continental shelf appears to have ceased; headland erosion is an unimportant source. Carbonate sands are a minor component of the coastal sediments. As estuary infilling nears completion, the potential for delivery of terrigenous sand to the sea by coastal rivers may be realised.
Prospects for a dominantly microwave-diagnosed magnetically confined fusion reactor
Creators: name: Volpe, Francesco A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Compared to present experiments, tokamak and stellarator reactors will be subject to higher heat loads, sputtering, erosion and subsequent coating, tritium retention, higher neutron fluxes, and a number of radiation effects. Additionally, neutral beam penetration in tokamak reactors will only be limited to the plasma edge. As a result, several optical, beam-based and magnetic diagnostics of today's plasmas might not be applicable to tomorrow's reactors, but the present discussion suggests that reactors could largely rely on microwave diagnostics, including techniques based on mode conversions and Collective Thomson Scattering.
description: 13 pages, 3 tables. 4th International Conference Frontiers in Diagnostic Technologies, Frascati (Italy), 30 March - 1 April 2016
Additional file 8: of Overexpression of RNF38 facilitates TGF-Î˛ signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
Creators: name: Peng, Rui
name: Zhang, Peng-Fei
name: Yang, Xuan
name: Wei, Chuan-Yuan
name: Huang, Xiao-Yong
name: Cai, Jia-Bin
name: Lu, Jia-Cheng
name: Gao, Chao
name: Sun, Hai-Xiang
name: Gao, Qiang
name: Bai, Dou-Sheng
name: Shi, Guo-Ming
name: Ke, Ai-Wu
name: Fan, Jia
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Table S3. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Down-regulated) (DOCX 37 kb)
Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans
Creators: name: Yaakoub, Hajar
name: Staerck, Cindy
name: Mina, Sara
name: Godon, Charlotte
name: Fleury, Maxime
name: Bouchara, Jean-Philippe
name: Calenda, Alphonse
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: The slowing-down de novo drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporium species and Lomentospora prolificans. Recent studies on Scedosporium responses to oxidative stress underscored the importance of targeting the underlying mechanisms. Auranofin, ebselen, PX-12, honokiol, and to a lesser extent, conoidin A are known to disturb redox-homeostasis systems in many organisms. Their antifungal activity was assessed against 27 isolates belonging to the major Scedosporium species: S. apiospermum, S. aurantiacum, S. boydii, S. dehoogii, S. minutisporum, and Lomentospora prolificans. Auranofin and honokiol were the most active against all Scedosporium species (mean MIC50 values of 2.875 and 6.143 μg/ml, respectively) and against L. prolificans isolates (mean MIC50 values of 4.0 and 3.563 μg/ml respectively). Combinations of auranofin with voriconazole or honokiol revealed additive effects against 9/27 and 18/27 isolates, respectively. Synergistic interaction between auranofin and honokiol was only found against one isolate of L. prolificans. The effects of auranofin upon exposure to oxidative stress were also investigated. For all species except S. dehoogii, the maximal growth in the presence of auranofin significantly decreased when adding a sublethal dose of menadione. The analysis of the expression of genes encoding oxidoreductase enzymes upon exposure of S. apiospermum to honokiol unveiled the upregulation of many genes, especially those coding peroxiredoxins, thioredoxin reductases, and glutaredoxins. Altogether, these data suggest that auranofin and honokiol act via dampening the redox balance and support their repurposing as antifungals against Scedosporium species and L. prolificans.
Additional file 6: of Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
Creators: name: Zhong, Jian
name: Zhenqing Ye
name: Lenz, Samuel
name: Clark, Chad
name: Bharucha, Adil
name: Gianrico Farrugia
name: Robertson, Keith
name: Zhiguo Zhang
name: Ordog, Tamas
name: Jeong-Heon Lee
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Measuring global ChIP enrichment by FRiP (fraction of reads in peaks). The score of FRiP (fraction of reads in peaks) was calculated by the previously published method [3]. FRiP scores for H3K4me3 and H3K27me3 ChIP-seq are visualized from the ENCODE reference (ENB and ENw) and the corresponding datasets obtained either with standard protocol for the lab (St) or by using different purification reagents as identified in Fig. 1. (PDF 94Â kb)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Cart. 193 (11 H 78), f. 0084r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Archives départementales de la Côte-d'Or, Cart. 193 (11 H 78), f. 0084r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Archives départementales de la Côte-d'Or, Cart. 193 (11 H 78), f. 0084r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
An investigation of systemic haemodynamic correlates of intracranial pressure
Creators: name: Hernandez, Julio Antonio Lara
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Monitoring intracranial pressure (ICP) is vital to decide the appropriate clinical treatment of patients with conditions potentially causing high ICP (e.g. brain injury, cerebral tumor, and hydrocephalus). On the path for finding an alternative means to invasive ICP measurement, the only means to date for accurate ICP monitoring, this study investigates the relationship of ICP with systemic cardiovascular signals ─heart rate (HR), aortic blood pressure (aBP), and carotid blood flow (cBF)─ via rat experiments and signal analysis techniques. Whilst induced changes in aBP and cBF resulted in evident alterations of ICP magnitude, increases of mean ICP up to 49 mmHg showed minimal effect on HR, aBP, or cBF signals. Thus, a stepwise mixed-model regression proved that the cardiovascular parameters here studied have minimal but significant predictive value of ICP magnitude. Changes in HR were found to modify the waveforms observed in ICP, aBP, and cBF signals, without altering the magnitude or phase of transfer function models. The transfer function models were constructed as a function of mean ICP, mean aBP, and aBP or cBF waveforms, and they showed potential to reproduce the ICP waveform (Root Mean Square Error (RMSE)≤4 mmHg), being more accurate for mean aBP above 100 mmHg and mean ICP below 20 mmHg (RMSE≤0.5 mmHg). Likewise, estimation of pulse ICP showed a small error (<1±1.0 mmHg) for mean ICP below 20 mmHg across a range of mean aBP (70-130 mmHg), proving considerable accuracy improvement in relation to previous studies.
Additional file 8 of Asymmetric expression of homoeologous genes contributes to dietary adaption of an allodiploid hybrid fish derived from Megalobrama amblycephala (♀) × Culter alburnus (♂)
Creators: name: Li, Wuhui
name: Wang, Shi
name: Hu, Jie
name: Tang, Chenchen
name: Wu, Chang
name: Liu, Junmei
name: Ren, Li
name: Sun, Chengfei
name: Dong, Junjian
name: Liu, Shaojun
name: Ye, Xing
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8. Supplement tables (Table S1, Table S2 and Table S3).
Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells
Creators: name: Peng, Ju-Yi
name: Shin, Dai-Lun
name: Li, Guangxing
name: Wu, Nai-Huei
name: Herrler, Georg
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Coronaviruses and influenza viruses are circulating in humans and animals all over the world. Co-infection with these two viruses may aggravate clinical signs. However, the molecular mechanisms of co-infections by these two viruses are incompletely understood. In this study, we applied air-liquid interface (ALI) cultures of well-differentiated porcine tracheal epithelial cells (PTECs) to analyze the co-infection by a swine influenza virus (SIV, H3N2 subtype) and porcine respiratory coronavirus (PRCoV) at different time intervals. Our results revealed that in short-term intervals, prior infection by influenza virus caused complete inhibition of coronavirus infection, while in long-term intervals, some coronavirus replication was detectable. The influenza virus infection resulted in (i) an upregulation of porcine aminopeptidase N, the cellular receptor for PRCoV and (ii) in the induction of an innate immune response which was responsible for the inhibition of PRCoV replication. By contrast, prior infection by coronavirus only caused a slight inhibition of influenza virus replication. Taken together, the timing and the order of virus infection are important determinants in co-infections. This study is the first to show the impact of SIV and PRCoV co- and super-infection on the cellular level. Our results have implications also for human viruses, including potential co-infections by SARS-CoV-2 and seasonal influenza viruses.
Diversification and prevalence of the quinolone resistance crpP genes and the crpP-carrying Tn6786-related integrative and conjugative elements in Pseudomonas aeruginosa
Creators: name: Zhu, Zhichen
name: Yang, Huiying
name: Yin, Zhe
name: Jing, Ying
name: Zhao, Yuee
name: Fu, Hongyu
name: Du, Hong
name: Zhou, Dongsheng
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: The quinolone resistance crpP genes can mediate decreased susceptibility to quinolones. However, diversification and prevalence of crpP genes and crpP-carrying integrative and conjugative elements (ICEs) still need to be elucidated. In this study, genome sequencing was conducted for 200 Chinese Pseudomonas aeruginosa isolates, 16 of which were fully sequenced. All the 37 available CrpP variants were collected for phylogenetic analysis, 10 CrpP enzymes were chosen to conduct cloning and antimicrobial susceptibility test, and 22 crpP-carrying Tn6786-related ICEs were selected for detail genetic dissection analysis. Then, typing/nomenclature schemes for crpP variants and crpP-carrying ICEs were established for the first time. The 10 representative CrpP enzymes were confirmed to mediate decreased susceptibility to one to three quinolones. Tn6786-related ICEs displayed high-level diversification in both nucleotide sequences and modular structures. Mainly, massive gene acquisition/loss occurred across the whole genomes of Tn6786-related ICEs. 53.5% (107/200) of the tested clinical P. aeruginosa isolates from China carried crpP genes, which were exclusively located within chromosome-borne Tn6786-related ICEs. The crpP-carrying ICEs were at active stages of evolution and had the high potential to be an important vector for the dissemination of resistance genes besides crpP. The present study furthered the understanding of the bioinformatics and epidemiology of crpP genes and crpP-carrying ICEs.
Blues down under the covers: canonisation and reinterpretive practices in Australia's blues music culture
Creators: name: Pleffer, Andrew James
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This dissertation examines the manner in which contemporary musicians participate in and contribute to the construction of canons in blues music. Focussing primarily on engagements with the genre by Australian artists, this analysis looks at the ways in which male African-American blues musicians consistently function as a fundamental presence and influence, even in internationally disseminated contexts. This is demonstrated particularly via perpetuated stereotypes of "the bluesman" as well as through the practice of recording versions of previously released blues "standards'. -- After an initial assessment of the existing literature, discussion immediately addresses "the bluesman" as a discursive construct and the preconceptions it subsequently (and inevitably) conveys to audiences about blues music. Working backwards toward the source, this study then discusses the musicians, songs, playing styles and equipment typically associated with blues music before identifying the integral role of recordings in representing, disseminating and reiterating the canon. -- From here discussion leads into a historical analysis of the practice of versioning previously recorded songs. Before focussing exclusively on how this applies to blues, this thesis reassesses the terminology currently attached to versioning practices in popular music and constructs a new glossary of terms that more aptly describes the creative processes applied by musicians to pre-existing material. The effectiveness of this language is then analysed with regard to various existing methodologies in blues literature, namely David Evans' Big Road Blues (1982). Following this, the new terminology is employed while carrying out a case study of an Australian compilation comprising entirely of local "reinterpretations" of the blues canon---The dig Australian Blues Project (Various, 2005). -- The remainder of the thesis is specifically concerned with three Australian artists who regularly engage with the blues genre by way of performing versions (or "covers") of blues songs previously recorded by African-American blues musicians. These case studies each provide biographical information and an overview of recorded output as well as discussion about how each artist fits into Australia's blues community. Most importantly though, each case study assesses the manner in which these contemporary musicians take part in constructing the blues canon by analysing five of their recorded versions and the patterns that appear in their respective approaches to recontextualising the genre for Australian audiences.
Cross-over to quasi-condensation: mean-field theories and beyond
Creators: name: Henkel, Carsten
name: Sauer, Tim-O.
name: Proukakis, N. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We analyze the cross-over of a homogeneous one-dimensional Bose gas from the ideal gas into the dense quasi-condensate phase. We review a number of mean-field theories, perturbative or self-consistent, and provide accurate evaluations of equation of state, density fluctuations, and correlation functions. A smooth crossover is reproduced by classical-field simulations based on the stochastic Gross-Pitaevskii equation, and the Yang-Yang solution to the one-dimensional Bose gas.
description: 21 pages, 16 figures
Additional file 5: of Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
Creators: name: Zhong, Jian
name: Zhenqing Ye
name: Lenz, Samuel
name: Clark, Chad
name: Bharucha, Adil
name: Gianrico Farrugia
name: Robertson, Keith
name: Zhiguo Zhang
name: Ordog, Tamas
name: Jeong-Heon Lee
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Mapping results of ChIP-seq reads generated through different purification reagents. (PDF 94Â kb)
title: ADCO, Cart. 186 (11 H 71), f. 0049r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0049r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1: of Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs
Creators: name: J. Dumková
name: T. Smutná
name: L. Vrlíková
name: P. Le Coustumer
name: Z. Večeřa
name: B. Dočekal
name: P. Mikuška
name: L. Čapka
name: P. Fictum
name: A. Hampl
name: M. Buchtová
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Calculation of deposited dose of PbO nanoparticles in the experiments. Figures S1, S2: The size distribution of nanoparticles with respect to the number of particles per unit volume in inhaled air and STEM images of PbO nanoparticles collected on TEM grids. Figures S3, S4: Weight of organs in the experiments. Figure S5: Effect of lead nanoparticles on spleen following 6 weeks exposure to PbO nanoparticles. Figure S6: Detection of proliferating cells in brain tissue. Tables S1, S2: Lead concentration in organs following 6 weeks exposure in the experiments. Tables S3, S4: Pathological changes in kidney, liver and lung in the experiments. (DOCX 4862 kb)
Particle swarm optimization for performance enhancement of electromagnetic band gap resonator antennas
Creators: name: Lalbakhsh, Ali
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis investigates the use of particle swarm optimization (PSO) algorithm for performance improvement of the electromagnetic band gap resonator antennas (ERAs) with a significantly less computational cost compared to other methods. Our recent investigations into aperture field phase distribution of ERAs indicates that the phase distribution is quite non-uniform for conventional ERAs, resulting in poor quality of radiation patterns and below-optimal directivity. A PSO algorithm is implemented to design two phase correcting structures (PCSs), one made from all dialectric heights and the other made from triple printed layers. A performance comparison between the proposed PSO algorithm and the embedded optimizer in CST Microwave Studio (CST MWS) revealed that the proposed PSO algorithm reached the final design fourteen times faster than the built-in PSO optimizer in CST MWS. The all-dialectric PCS designed by PSO has significantly enhanced the phase uniformity of the ERA, improving radiation patterns by 4.6 dB in peak directivity. Following this approach, a printed PCS was designed by the PSO algorithm to achieve a planar structure. The use of PSO resulted in creating the printed PCS by 2480 unit-cell simulations. On the other hand, to design such a PCS by parametric sweep, 729,000 unit-cell simulations are required. The printed PCS greatly outperforms its dialectric counterpart in terms of phase uniformity and radiation patterns. Aperture efficiency increased by almost ten times and the peak directivity also improved by 9.6 dB compared to the ERA without PCS. In the end, a low-profile bandpass frequency selective surface (FSS) was designed using the PSO algorithm to verify the versatility of the proposed algorithm in designing various electromagnetic devices. Such FSS can also be designed by the parametric sweep at a significantly higher computational cost.
Investigation into the pathogenic cyclin FE624K sporadic mutation in amyotrophic lateral sclerosis and frontotemporal dementia
Creators: name: de los Angeles Morales Villalva, Maria
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Motor neuron disease (MND) is an umbrella term for many neurodegenerative disorders that are characterised with a range of symptoms and signs, from dysfunction to an individual's locomotion to abnormalities in cognitive functions. Two fatal neurodegenerative diseases that share molecular and pathogenic characteristics are amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which have been shown to present dysfunction in mechanisms that regulate protein homeostasis (proteostasis). Dysfunction of proteostasis may arise due to the presence of aggregated protein inclusions, potentially an underlying cause of ALS/FTD pathology. Recently, the CCNF gene has been identified to present various ALS/FTD mutants, that have been discovered in both familial and sporadic cases. The CCNF gene encodes for cyclin F, a protein involved in cell-cycle processes and ubiquitylation, specifically a module of the Skp1-Cul1-F-Box (SCF) E3 ubiquitin ligase complex, which is involved in quality control mechanisms that regulate proteostasis levels. Recent studies have focused on the familial cyclin FS621G mutation, demonstrating hyper-ubiquitylation due to autophagy pathway dysfunction and impairment of regulatory phosphorylation. However, further research is needed to identify whether other CCNF mutants, such as the sporadic cyclin FE624K mutant presents with similar or different familial ALS/FTD pathogenesis. For this thesis, the aim is to generate and characterise the cyclin FE624K mutant in HEK293 cells and investigate whether it causes any perturbations to cellular pathways as well as perturbed protein-protein interactions that may be shared or unique to the familial cyclin FS621G mutant and cyclin F wild-type. Expression of sporadic cyclin FE624K mutant revealed a decrease in phosphorylation and no change in K48-ubiquitylation of proteins. Global proteomic analysis revealed inhibition of pathways involved in actin cytoskeleton regulation. Proteomic analysis of immunoprecipitated cyclin FE624K identified proteins that clustered within a ubiquitin- and proteasome-associated protein network and proteins that clustered within the oxidative stress response. Perturbed cyclin FE624K protein interactors involved in these networks suggests dysregulation may lead to cellular proteostasis impairments and ultimately lead to neurodegeneration. Comparative analysis with the familial cyclin FS621G mutant elucidates differences in cellular mechanisms between sporadic and familial mutations that govern ALS/FTD pathology.
title: ADCO, Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0308
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0308, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0308, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Saint-Seine
description: Provenance: http://www.wikidata.org/entity/Q2820709
Additional file 1: of Gastric Parietal Cell and Intestinal Goblet Cell Secretion: a Novel Cell-Mediated In Vivo Metal Nanoparticle Metabolic Pathway Enhanced with Diarrhea Via Chinese Herbs
Creators: name: Liu, Yanlei
name: Liu, Kunlu
name: Yang, Meng
name: Han, Yue
name: Zhang, Qian
name: Conde, João
name: Yang, Yuming
name: Alfranca, Gabriel
name: Wang, Yuxia
name: Ma, Lijun
name: Zhang, Yingge
name: Song, Jie
name: Pan, Yunxiang
name: Ni, Jian
name: Cui, Daxiang
Publisher: name: figshare
Year: 2019
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Figure S1. Characterization of Fe3O4 magnetic nanoparticles by HR-TEM. Figure S2. Characterization of Au clusters by HR-TEM. Scale bar, 5 nm. Figure S3. (A) TEM image of GNRs. Scale bar, 100 nm; (B) absorption spectra of GNRs. Figure S4. Distribution of Au nanoclusters in intestinal tissues. (A) Control groups; (B) ligation groups. Figure S5. Distribution of magnetic nanoparticles in goblet cells of mice with CBD ligation. Figure S6. Distribution of gold nanorods in goblet cells of mice with CBD ligation. Figure S7. Quantitative analysis of nanoparticles in feces based on ICP-MS. (DOCX 2987 kb)
Additional file 4: of Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
Creators: name: Zhong, Jian
name: Zhenqing Ye
name: Lenz, Samuel
name: Clark, Chad
name: Bharucha, Adil
name: Gianrico Farrugia
name: Robertson, Keith
name: Zhiguo Zhang
name: Ordog, Tamas
name: Jeong-Heon Lee
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology

description: DNA profiles in H3K4me3 and H3K27me3 ChIP-seq libraries generated through different purification reagents. After library amplification with 12 cycles of PCR, DNAs were analyzed by the Fragment Analyzer. Lane 1 (EDL St), the library from 1 ng of purified ChIP DNA from aliquot A; Lane 2 (1 ng QmM), the library from stored DNA in MaxyClear tube after purification by MinElute PCR Purification Kit from aliquot B; Lane 3 (1 ng QmP), the library from stored DNA in Premium Tube after purification by MinElute PCR Purification Kit from aliquot B; Lane 4 (Input), the library from 1 ng of purified input DNA from the aliquot A. Left panel is the profile of H3K4me3 libraries, and right panel is the profile of H3K27me3 libraries. (PDF 123 kb)
Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone
Creators: name: Robbe-Saule, Marie
name: Foulon, Mélanie
name: Poncin, Isabelle
name: Esnault, Lucille
name: Varet, Hugo
name: Legendre, Rachel
name: Besnard, Alban
name: Grzegorzewicz, Anna E.
name: Jackson, Mary
name: Canaan, Stéphane
name: Marsollier, Laurent
name: Marion, Estelle
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and the third most common mycobacterial disease worldwide. Without early treatment, M. ulcerans provokes massive skin ulcers, caused by the mycolactone toxin, its main virulence factor. However, spontaneous healing may occur in Buruli ulcer patients several months or years after the disease onset. We have shown, in an original mouse model, that bacterial load remains high and viable in spontaneously healed tissues, with a switch of M. ulcerans to low levels of mycolactone production, adapting its strategy to survive in such a hostile environment. This original model offers the possibility to investigate the regulation of mycolactone production, by using an RNA-seq strategy to study bacterial adaptation during mouse infection. Pathway analysis and characterization of the tissue environment showed that the bacillus adapted to its new environment by modifying its metabolic activity and switching nutrient sources. Thus, M. ulcerans ensures its survival in healing tissues by reducing its secondary metabolism, leading to an inhibition of mycolactone synthesis. These findings shed new light on mycolactone regulation and pave the way for new therapeutic strategies.
Dry surface biofilm a persistent source of pathogens in hospital: decontamination and infection control
Creators: name: Chowdhury, Durdana
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Environmental surface cleaning and disinfection is crucial for preventing HAI and maintaining patient safety. However, biofilms incorporating multiple bacterial species form on dry hospital surfaces. These biofilms are tolerant to biocides making their eradication difficult. Persistence of pathogens on surfaces increases the risk of transmission and development of HAI. Aims:1) To determine if bacteria can be transmitted from dry surface biofilm (DSB) to healthcare workers' hands and through cotton sheets. 2) To develop and test new removal chemistries against dry surface biofilm utilising laboratory models. 3) To develop a mixed species biofilm model analogous to the hospital surface DSB to determine its composition, the effect of multiple species on biofilm's susceptibility to detergents and disinfectants and analyse proteomics and transcriptomics technique. 4) To investigate protein regulatory changes in DSB compared with traditional hydrated biofilm and confirmation with RT PCR. This study revealed that: 1) DSB is highly transmissible. The total bacterial number transferred are sufficient to cause disease. 2) Soil inactivates the commonly used disinfectants. Peracetic acid reduces 64% of the biofilm mass and >6 Log10 viability in single species DSB, 48% of the biofilm mass in mixed DSB in the presence of soil. 3) This study developed a mixed species DSB model with reproducible cell number within and between repeated experiments. This mixed biofilm model was employed to assess the effectiveness of disinfectants. 4) These findings clearly imply that S. aureus biofilms represent a unique growth condition in terms of overall numbers of differentially expressed distinct proteins and genes. This study establishes the transmissibility of bacteria from DSB affirming it to be a potential source of HAI and determined that currently surface disinfectants and methods are insufficient to completely eradicate DSB. This study also established different changes in protein and genetic expression in biofilm, this might act as target group to invent new effective disinfectant for complete eradication of DSB.
On the integral law of thermal radiation
Creators: name: Gusev, Yuri V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Classical Physics (physics.class-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Optics (physics.optics)
subject: FOS: Physical sciences
subject: 78A40

description: The integral law of thermal radiation by finite size emitters is studied. Two geometrical characteristics of a radiating body or a cavity, its volume and its boundary area, define two terms in its radiance. The term defined by the volume corresponds to the Stefan-Boltzmann law. The term defined by the boundary area is proportional to the third power of temperature and inversely proportional to the emitter's effective size, which is defined as the ratio of its volume to its boundary area. It is shown that the cubic temperature contribution is observed in experiments. This term explains the intrinsic uncertainty of the NPL experiment on radiometric determination of the Stefan-Boltzmann constant. It is also quantitatively confirmed by data from the NIST calibration of cryogenic blackbodies. Its relevance to the size of source effect in optical radiometry is proposed. The conjecture that this generalized law is valid for arbitrary temperature and effective size is supported by the experiments on thermal emission from nano-heaters.
description: 23 pages, 1 table
Oral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice
Creators: name: Zhu, Wenwen
name: Wang, Jia
name: Zhao, Na
name: Zheng, Rui
name: Wang, Dalu
name: Liu, Weiwei
name: Liu, Beixing
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Changes in the intestinal microbiota indirectly impact the health of mucosa distal to the intestine, particularly the respiratory tract. However, the effects of intestinal microbiota dysbiosis on the regulation of respiratory syncytial virus (RSV) infection are not clear. In this study, we examined the effects of altering the intestinal microbiota on the pulmonary immune response against RSV infection. BALB/c mice were treated with streptomycin before infection with RSV to study the altered immune response. The ingestion of streptomycin led to a marked alteration in the intestinal microbiota with a reduced abundance of Lactobacillus and Clostridium genera, followed by greatly aggravated pulmonary inflammation in response to RSV infection. This aggravated inflammation was associated with a dysregulated immune response against RSV infection, characterized by the increased expression of IFN-γ and IL-17 and increased pulmonary M1-like macrophage polarization, and decreased expression of IL-5. Supplementation of Clostridium butyricum (CB) prevented aggravated inflammation and the dysregulated immune response characterized by greater M2 polarization of pulmonary macrophages and decreased release of IFN-γ and IL-17 as well as increased IL-5 levels. Furthermore, in vitro and in vivo experiments identified that butyrate, the main metabolite produced by CB, promoted M2 polarization of macrophages in RSV-infected mice exposed to streptomycin. Together, these results demonstrate the mechanism by which intestinal microbiota modulate the pulmonary immune response to RSV infection.
Additional file 1: of Does being physically active prevent future disability in older people? Attenuated effects when taking time-dependent confounders into account
Creators: name: Kreisel, Stefan
name: Blahak, Christian
name: HansjĂśrg BĂ¤Zner
name: Hennerici, Michael
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supporting information. The Supporting information provides a non-technical introduction on how marginal structural models can be estimated generically. We provide a practical demonstration of how to implement this type of modeling using standard statistical software, discussing benefits and caveats. We include an additional figure that highlights the underpinnings of time-varying treatment, time-varying confounding and the inverse probability of treatment weight. The estimation steps presented in the main manuscript are cross-referenced in the Supporting information. (DOC 1488Â kb)
Whole genome analysis unveils genetic diversity and potential virulence determinants in Vibrio parahaemolyticus associated with disease outbreak among cultured Litopenaeus vannamei (Pacific white shrimp) in India
Creators: name: Prithvisagar, Kattapuni Suresh
name: Kumar, Ballamoole Krishna
name: Kodama, Toshio
name: Rai, Praveen
name: Iida, Tetsuya
name: Karunasagar, Iddya
name: Karunasagar, Indrani
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Vibrio parahaemolyticus has caused widespread mortality in Indian shrimp aquaculture in recent years. However, there are insufficient genome data for the isolates from Indian shrimp vibriosis to analyze genetic diversity and track the acquisition of genetic features that could be involved in virulence and fitness. In this study, we have performed genome analysis of V. parahaemolyticus isolated from moribund shrimps collected from shrimp farms along coastal Karnataka, India, for better understanding of their diversity and virulence. Five newly sequenced genomes of V. parahaemolyticus along with 40 genomes retrieved from NCBI were subjected to comparative genome analysis. The sequenced genomes had an overall genome size of 5.2 Mb. MLST analysis and core genome phylogenomic analysis revealed considerable genetic diversity among the isolates obtained from the moribund shrimps. Interestingly, none of the V. parahaemolyticus isolates possessed the classical features (PirAB) of the strains associated with Acute Hepatopancreatic Necrosis Disease (AHPND). This study also revealed the presence of multiple virulence attributes, including ZOT, ACE and RTX toxins, secretion systems, and mobile genetic elements. The findings of this study provide insights into the possible transition of an environmental V. parahaemolyticus to emerge as pathogens of aquaculture species by increasing its virulence and host adaptation. Future studies focusing on continuous genomic surveillance of V. parahaemolyticus are required to study the evolution and transmission of new variants in shrimp aquaculture, as well as to design and implement biosecurity programs to prevent disease outbreaks.
Environmental stress proteomics-investigating the effects of heavy metal pollution and ocean acidification in agriculturally important marine species
Creators: name: Muralidharan, Sridevi
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis is aimed at furthering our understanding of the biological impacts in important marine species of two environmental issues facing Australia - heavy metal pollution from anthropogenic activities and ocean acidification from increasing carbon dioxide levels. The effects of these stressors were explored by investigating the stress responses in agriculturally important aquatic marine animals, such as oysters and amphipods, using quantitative proteomics. We demonstrated the usefulness of labeled as well as label-free proteomics approaches in gaining insight of such environmental stresses in these animals at the cellular and molecular level.