cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neutral current quasielastic (anti)neutrino scattering beyond the Fermi gas model at MiniBooNE and BNL kinematics
Creators: name: Ivanov, M. V.
name: Antonov, A. N.
name: Barbaro, M. B.
name: Giusti, C.
name: Meucci, A.
name: Caballero, J. A.
name: Gonzalez-Jimenez, R.
name: de Guerra, E. Moya
name: Udias, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Neutral current quasielastic (anti)neutrino scattering cross sections on a $^{12}$C target are analyzed using a realistic spectral function $S(p,E)$ that gives a scaling function in accordance with the ($e,e'$) scattering data. The spectral function accounts for the nucleon-nucleon (NN) correlations by using natural orbitals (NOs) from the Jastrow correlation method and has a realistic energy dependence. The standard value of the axial mass $M_A= 1.032$ GeV is used in all calculations. The role of the final-state interaction (FSI) on the spectral and scaling functions, as well as on the cross sections is accounted for. A comparison of the calculations with the empirical data of the MiniBooNE and BNL experiments is performed. Our results are analyzed in comparison with those when NN correlations are not included, and also with results from other theoretical approaches, such as the relativistic Fermi gas (RFG), the relativistic mean field (RMF), the relativistic Green's function (RGF), as well as with the SuperScaling Approach (SuSA) based on the analysis of quasielastic electron scattering.
description: 12 pages, 7 figures
Continuum percolation of polydisperse hyperspheres in infinite dimensions
Creators: name: Grimaldi, Claudio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We analyze the critical connectivity of systems of penetrable $d$-dimensional spheres having size distributions in terms of weighed random geometrical graphs, in which vertex coordinates correspond to random positions of the sphere centers and edges are formed between any two overlapping spheres. Edge weights naturally arise from the different radii of two overlapping spheres. For the case in which the spheres have bounded size distributions, we show that clusters of connected spheres are tree-like for $d\rightarrow \infty$ and they contain no closed loops. In this case, we find that the mean cluster size diverges at the percolation threshold density $η_c\rightarrow 2^{-d}$, independently of the particular size distribution. We also show that the mean number of overlaps for a particle at criticality $z_c$ is smaller than unity, while $z_c\rightarrow 1$ only for spheres with fixed radii. We explain these features by showing that in the large dimensionality limit the critical connectivity is dominated by the spheres with the largest size. Assuming that closed loops can be neglected also for unbounded radii distributions, we find that the asymptotic critical threshold for systems of spheres with radii following a lognormal distribution is no longer universal, and that it can be smaller than $2^{-d}$ for $d\rightarrow\infty$.
description: 11 pages, 5 figures
Statistical methodology from Effects of mismatches between dispersal traits and landscape structure on dispersal success in fragmented landscapes
Creators: name: Atkins, Justine L.
name: Perry, George L. W.
name: Dennis, Todd E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Description of Broken-Stick random-number generation techniques used as part of model analysis.
The SL1-SL2 (Stem-Loop) Domain Is the Primary Determinant for Stability of the Gamma Retroviral Genomic RNA Dimer
Creators: name: Gherghe, Cristina
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Retroviral genomes are assembled from two sense-strand RNAs by noncovalent interactions at their 5' ends, forming a dimer. The RNA dimerization domain is a potential target for antiretroviral therapy and represents a compelling RNA folding problem. The fundamental dimerization unit for the Moloney murine sarcoma gamma retrovirus spans a 170-nucleotide minimal dimerization active sequence. In the dimer, two self-complementary sequences, PAL1 and PAL2, form intermolecular duplexes, and an SL1-SL2 (stem-loop) domain forms loop-loop base pairs, mediated by GACG tetraloops, and extensive tertiary interactions. To develop a framework for assembly of the retroviral RNA dimer, we quantified the stability of and established nucleotide resolution secondary structure models for sequence variants in which each motif was compromised. Base pairing and tertiary interactions between SL1-SL2 domains contribute a large free energy increment of -10 kcal/mol. In contrast, even though the PAL1 and PAL2 intermolecular duplexes span 10 and 16 bp in the dimer, respectively, they contribute only -2.5 kcal/mol to stability, roughly equal to a single new base pair. First, these results emphasize that the energetic costs for disrupting interactions in the monomer state nearly balance the PAL1 and PAL2 base pairing interactions that form in the dimer. Second, intermolecular duplex formation plays a biological role distinct from simply stabilizing the structure of the retroviral genomic RNA dimer.
(1545) Edward Thompson Simmons
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Entanglement rates for bipartite open systems
Creators: name: Vershynina, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We provide upper bound on the maximal rate at which irreversible quantum dynamics can generate entanglement in a bipartite system. The generator of irreversible dynamics consists of a Hamiltonian and dissipative terms in Lindblad form. The relative entropy of entanglement is chosen as a measure of entanglement in an ancilla-free system. We provide an upper bound on the entangling rate which has a logarithmic dependence on a dimension of a smaller system in a bipartite cut. We also investigate the rate of change of quantum mutual information in an ancilla-assisted system and provide an upper bound independent of dimension of ancillas.
Supplementary table S1 and figures S1-S4 from Development of behavioural automaticity by extended Pavlovian training in an insect.
Creators: name: Mizunami, Makoto
name: Hirohata, Sho
name: Sato, Ai
name: Arai, Ryoichi
name: Terao, Kanta
name: Sato, Misato
name: Yukihisa Matsumoto
Publisher: name: The Royal Society
Year: 2019
Subjects: Neuroscience

description: Table S1 and figures S1-S4
Overview, Design Concepts, Details and Preliminary testing and parameterisation of the dispersal model from Effects of mismatches between dispersal traits and landscape structure on dispersal success in fragmented landscapes
Creators: name: Atkins, Justine L.
name: Perry, George L. W.
name: Dennis, Todd E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Full dispersal model description following the standard Overview, Design Concepts, Details (ODD) format. Description and figures showing results of initial tests performed on the simulation model: software checks and tests to determine stopping points, numbers of replicates, and parameter ranges.
Supplementary DATA set from Development of behavioural automaticity by extended Pavlovian training in an insect.
Creators: name: Mizunami, Makoto
name: Hirohata, Sho
name: Sato, Ai
name: Arai, Ryoichi
name: Terao, Kanta
name: Sato, Misato
name: Yukihisa Matsumoto
Publisher: name: The Royal Society
Year: 2019
Subjects: Neuroscience

description: Supplementary DATA set
Supplementary table S1 and figures S1-S4 from Development of behavioural automaticity by extended Pavlovian training in an insect
Creators: name: Mizunami, Makoto
name: Hirohata, Sho
name: Sato, Ai
name: Arai, Ryoichi
name: Terao, Kanta
name: Sato, Misato
name: Yukihisa Matsumoto
Publisher: name: The Royal Society
Year: 2018
Subjects: Neuroscience

description: Table S1 and figures S1-S4
A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes
Creators: name: Vuagniaux, Grégoire
name: Harris, Michael
name: Firsov, Dmitri
name: Rossier, Bernard C.
name: Stutts, M. Jackson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The amiloride-sensitive epithelial sodium channel (ENaC) constitutes a limiting step in sodium reabsorption across distal airway epithelium and controlling mucociliary clearance. ENaC is activated by serine proteases secreted in the extracellular milieu. In cystic fibrosis lungs, high concentrations of secreted neutrophil elastase (NE) are observed. hNE could activate ENaC and contribute to further decreased mucociliary clearance. The aims of this study were (i) to test the ability of an engineered human neutrophil elastase inhibitor (EPI-hNE4) to specifically inhibit the elastase activation of ENaC-mediated amiloride-sensitive currents (I(Na)) and (ii) to examine the effect of elastase on cell surface expression of ENaC and its cleavage pattern (exogenous proteolysis). Oocytes were exposed to hNE (10-100 microg/ml) and/or trypsin (10 microg/ml) for 2-5 min in the presence or absence of EPI-hNE4 (0.7 microm). hNE activated I(Na) 3.6-fold (p < 0.001) relative to non-treated hENaC-injected oocytes. EPI-hNE4 fully inhibited hNE-activated I(Na) but had no effect on trypsin- or prostasin-activated I(Na). The co-activation of I(Na) by hNE and trypsin was not additive. Biotinylation experiments revealed that cell surface gamma ENaC (but not alpha or beta ENaC) exposed to hNE for 2 min was cleaved (as a 67-kDa fragment) and correlated with increased I(Na). The elastase-induced exogenous proteolysis pattern is distinct from the endogenous proteolysis pattern induced upon preferential assembly, suggesting a causal relationship between gamma ENaC cleavage and ENaC activation, taking place at the plasma membrane.
Supplementary DATA set from Development of behavioural automaticity by extended Pavlovian training in an insect
Creators: name: Mizunami, Makoto
name: Hirohata, Sho
name: Sato, Ai
name: Arai, Ryoichi
name: Terao, Kanta
name: Sato, Misato
name: Yukihisa Matsumoto
Publisher: name: The Royal Society
Year: 2018
Subjects: Neuroscience

description: Supplementary DATA set
(1546) Susanna Fish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1547) Edward Simmons
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1544) Grace Simmons
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Outage Minimization for a Fading Wireless Link with Energy Harvesting Transmitter and Receiver
Creators: name: Zhou, Sheng
name: Chen, Tingjun
name: Chen, Wei
name: Niu, Zhisheng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper studies online power control policies for outage minimization in a fading wireless link with energy harvesting transmitter and receiver. The outage occurs when either the transmitter or the receiver does not have enough energy, or the channel is in outage, where the transmitter only has the channel distribution information. Under infinite battery capacity and without retransmission, we prove that threshold-based power control policies are optimal. We thus propose disjoint/joint threshold-based policies with and without battery state sharing between the transmitter and receiver, respectively. We also analyze the impact of practical receiver detection and processing on the outage performance. When retransmission is considered, policy with linear power levels is adopted to adapt the power thresholds per retransmission. With finite battery capacity, a three dimensional finite state Markov chain is formulated to calculate the optimal parameters and corresponding performance of proposed policies. The energy arrival correlation between the transmitter and receiver is addressed for both finite and infinite battery cases. Numerical results show the impact of battery capacity, energy arrival correlation and detection cost on the outage performance of the proposed policies, as well as the tradeoff between the outage probability and the average transmission times.
description: 15 pages, 8 figures, accepted by IEEE Journal on Selected Areas in Communications
Architecture of the Bacteriophage T4 Replication Complex Revealed with Nanoscale Biopointers
Creators: name: Makhov, Alexander M.
name: Chastain II, Paul D.
name: Nossal, Nancy G.
name: Griffith, Jack D.
name: Jones, Charles E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Our previous electron microscopy of DNA replicated by the bacteriophage T4 proteins showed a single complex at the fork, thought to contain the leading and lagging strand proteins, as well as the protein-covered single-stranded DNA on the lagging strand folded into a compact structure. "Trombone" loops formed from nascent lagging strand fragments were present on a majority of the replicating molecules (Chastain, P., Makhov, A. M., Nossal, N. G., and Griffith, J. D. (2003) J. Biol. Chem. 278, 21276-21285). Here we probe the composition of this replication complex using nanoscale DNA biopointers to show the location of biotin-tagged replication proteins. We find that a large fraction of the molecules with a trombone loop had two pointers to polymerase, providing strong evidence that the leading and lagging strand polymerases are together in the replication complex. 6% of the molecules had two loops, and 31% of these had three pointers to biotin-tagged polymerase, suggesting that the two loops result from two fragments that are being extended simultaneously. Under fixation conditions that extend the lagging strand, occasional molecules show two nascent lagging strand fragments, each being elongated by a biotin-tagged polymerase. T4 41 helicase is present in the complex on a large fraction of actively replicating molecules but on a smaller fraction of molecules with a stalled polymerase. Unexpectedly, we found that 59 helicase-loading protein remains on the fork after loading the helicase and is present on molecules with extensive replication.
Self-similar structure and experimental signatures of suprathermal ion distribution in inertial confinement fusion implosions
Creators: name: Kagan, Grigory
name: Svyatskiy, D.
name: Rinderknecht, H. G.
name: Rosenberg, M. J.
name: Zylstra, A. B.
name: Huang, C. -K.
name: McDevitt, C. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The distribution function of suprathermal ions is found to be self-similar under conditions relevant to inertial confinement fusion hot-spots. By utilizing this feature, interference between the hydro-instabilities and kinetic effects is for the first time assessed quantitatively to find that the instabilities substantially aggravate the fusion reactivity reduction. The ion tail depletion is also shown to lower the experimentally inferred ion temperature, a novel kinetic effect that may explain the discrepancy between the exploding pusher experiments and rad-hydro simulations and contribute to the observation that temperature inferred from DD reaction products is lower than from DT at National Ignition Facility.
description: Revised version accepted for publication in PRL. "Copyright (2015) by the American Physical Society."
Supplementary figures and tables from Trait variation in extreme thermal environments under constant and fluctuating temperatures.
Creators: name: Salinas, Santiago
name: Irvine, Shannon E.
name: Schertzing, Claire L.
name: Golden, Shelby Q.
name: Munch, Stephan B.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Fig S1: Temperature records (from 09/18/2013 to 08/18/2017), recorded in 15-min intervals, from the Lake Superior National Estuarine Research Reserve (Pokegama Bay station [lkspowq], water depth 1-2 m). Note that fathead minnows prefer shallower waters, making the maximum temperatures experienced likely higher than 27-28°C as observed in this plot. Fig S2: Growth trajectories for all fish analyzed in the experiment. Table S1: Model selection results for breakpoint regression analysis of every trait measured vs. temperature. Table S2: Model selection results for breakpoint regression analysis of variance in length-at-age vs. temperature. Table S3: MANOVA results on (a) all of the traits combined, (b) all the length-at-age measurements, (c) all of the morphometric and meristic traits, and (d) all the fluctuating asymmetry (FA) traits. Models = “full”: intercept + temp+fluct+temp*fluct; “no interaction”: intercept + temp+fluct; “no temp”: intercept + fluct; “no fluct”: intercept + temp.
title: Local Self-Governance in the Context of Weak Statehood in Antiquity and the Modern Era. A Program for a Fresh Perspective
Creators: name: Pfeilschifter, Rene
name: Lauth, Hans-Joachim
name: Fischer, Doris
name: Rothfuß, Eberhard
name: Schachner, Andreas
name: Schmitz, Barbara
name: Werthmann, Katja
Publisher: name: Universität Würzburg
Year: 2020
Subjects: subject: 220 Bibel

description: LoSAM Working Papers; 1(eng)
Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4
Creators: name: Benovic, Jeffrey L.
name: Bhandari, Deepali
name: Trejo, Joann
name: Marchese, Adriano
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The chemokine receptor CXCR4 is rapidly targeted for lysosomal degradation by the E3 ubiquitin ligase atrophin-interacting protein 4 (AIP4). Although it is known that AIP4 mediates ubiquitination and degradation of CXCR4 and that perturbations in these events contribute to disease, the mechanisms mediating AIP4-dependent regulation of CXCR4 degradation remain poorly understood. Here we show that AIP4 directly interacts with the amino-terminal half of nonvisual arrestin-2 via its WW domains. We show that depletion of arrestin-2 by small interfering RNA blocks agonist-promoted degradation of CXCR4 by preventing CXCR4 trafficking from early endosomes to lysosomes. Surprisingly, CXCR4 internalization and ubiquitination remain intact, suggesting that the interaction between arrestin-2 and AIP4 is not required for ubiquitination of the receptor at the plasma membrane but perhaps for a later post-internalization event. Accordingly, we show that activation of CXCR4 promotes the interaction between AIP4 and arrestin-2 that is consistent with a time when AIP4 co-localizes with arrestin-2 on endocytic vesicles. Taken together, our data suggest that the AIP4.arrestin-2 complex functions on endosomes to regulate sorting of CXCR4 into the degradative pathway.
(1542) George Frederick Newton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Equilibrium Points and Periodic Orbits in the Vicinity of Asteroids with an Application to 216 Kleopatra
Creators: name: Jiang, Yu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In this study, equilibrium points and periodic orbits in the potential field of asteroids are investigated. We present the linearized equations of motion relative to the equilibrium points and characteristic equations. We find that the distribution of characteristic multipliers of periodic orbits around the equilibrium point and the distribution of eigenvalues of the equilibrium point correspond to each other. The distribution of eigenvalues of the equilibrium point confirms the topology and the stability of periodic orbits around the equilibrium point.
description: 21 pages, 6 figures, Earth, Moon, and Planets 2015
Skyrmion dynamics in chiral ferromagnets
Creators: name: Komineas, Stavros
name: Papanicolaou, Nikos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the dynamics of skyrmions in Dzyaloshinskii-Moriya materials with easy-axis anisotropy. An important link between topology and dynamics is established through the construction of unambiguous conservation laws obtained earlier in connection with magnetic bubbles and vortices. In particular, we study the motion of a topological skyrmion with skyrmion number $Q=1$ and a non-topological skyrmionium with $Q=0$ under the influence of an external field gradient. The $Q=1$ skyrmion undergoes Hall motion perpendicular to the direction of the field gradient with a drift velocity proportional to the gradient. In contrast, the non-topological $Q=0$ skyrmionium is accelerated in the direction of the field gradient, thus exhibiting ordinary Newtonian motion. When the external field is switched off the $Q=1$ skyrmion is spontaneously pinned around a fixed guiding center, whereas the $Q=0$ skyrmionium moves with constant velocity $v$. We give a systematic calculation of a skyrmionium traveling with any constant velocity $v$ that is smaller than a critical velocity $v_c$.
description: 9 pages, 11 figures
Quantum Structure of Negation and Conjunction in Human Thought
Creators: name: Aerts, Diederik
name: Sozzo, Sandro
name: Veloz, Tomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We analyse in this paper the data collected in a set of experiments performed on human subjects on the combination of natural concepts. We investigate the mutual influence of conceptual conjunction and negation by measuring the membership weights of a list of exemplars with respect to two concepts, e.g., 'Fruits' and 'Vegetables', and their conjunction 'Fruits And Vegetables', but also their conjunction when one or both concepts are negated, namely, 'Fruits And Not Vegetables', 'Not Fruits And Vegetables' and 'Not Fruits And Not Vegetables'. Our findings sharpen existing analysis on conceptual combinations, revealing systematic and remarkable deviations from classical (fuzzy set) logic and probability theory. And, more important, our results give further considerable evidence to the validity of our quantum-theoretic framework for the combination of two concepts. Indeed, the representation of conceptual negation naturally arises from the general assumptions of our two-sector Fock space model, and this representation faithfully agrees with the collected data. In addition, we find a further significant deviation and a priori unexpected from classicality, which can exactly be explained by assuming that human reasoning is the superposition of an 'emergent reasoning' and a 'logical reasoning', and that these two processes can be successfully represented in a Fock space algebraic structure.
description: 44 pages. arXiv admin note: text overlap with arXiv:1406.2358
(1543) Margaret Mary [Newton]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Leptogenesis via Higgs Condensate Relaxation
Creators: name: Yang, Louis
name: Pearce, Lauren
name: Kusenko, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: An epoch of Higgs relaxation may occur in the early universe during or immediately following postinflationary reheating. It has recently been pointed out that leptogenesis may occur in minimal extensions of the Standard Model during this epoch. We analyse Higgs relaxation taking into account the effects of perturbative and non-perturbative decays of the Higgs condensate, and we present a detailed derivation of the relevant kinetic equations and of the relevant particle interaction cross sections. We identify the parameter space in which a sufficiently large asymmetry is generated.
description: 18 pages, 14 figures
Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif
Creators: name: Der, Channing J.
name: Sondek, John
name: Karnoub, Antoine E.
name: Snyder, Jason T.
name: Rossman, Kent L.
name: Yohe, Marielle E.
name: Gardner, Olivia S.
name: Graves, Lee M.
name: Gershburg, Svetlana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catalyze exchange. Because the ability of many Dbl-family proteins to catalyze exchange is constitutively activated by truncations N-terminal to their DH domains, it has been proposed that the activity of Dbl-family proteins is regulated by auto-inhibition. However, the exact mechanisms of regulation of Dbl-family proteins remain poorly understood. Here we show that the Dbl-family protein, Tim, is auto-inhibited by a short, helical motif immediately N-terminal to its DH domain, which directly occludes the catalytic surface of the DH domain to prevent GTPase activation. Similar to the distantly related Vav isozymes, auto-inhibition of Tim is relieved by truncation, mutation, or phosphorylation of the auto-inhibitory helix. A peptide comprising the helical motif inhibits the exchange activity of Tim in vitro. Furthermore, substitutions within the most highly conserved surface of the DH domain designed to disrupt interactions with the auto-inhibitory helix also activate the exchange process.
Automated Penetration Testing Framework for Smart-Home-Based IoT Devices
Creators: name: Akhilesh, R
name: Bills, O
name: Chilamkurti, Naveen
name: Chowdhury, Mohammad Jabed Morshed
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 46
subject: Information and computing sciences

description: Security testing is fundamental to identifying security vulnerabilities on smart home-based IoT devices. For this, penetration testing is the most prominent and effective solution. However, testing the IoT manually is cumbersome and time-consuming. In addition, penetration testing requires a deep knowledge of the possible attacks and the available hacking tools. Therefore, this study emphasises building an automated penetration testing framework to discover the most common vulnerabilities in smart home-based IoT devices. This research involves exploring (studying) different IoT devices to select five devices for testing. Then, the common vulnerabilities for the five selected smart home-based IoT devices are examined, and the corresponding penetration testing tools required for the detection of these vulnerabilities are identified. The top five vulnerabilities are identified from the most common vulnerabilities, and accordingly, the corresponding tools for these vulnerabilities are discovered. These tools are combined using a script which is then implemented into a framework written in Python 3.6. The selected IoT devices are tested individually for known vulnerabilities using the proposed framework. For each vulnerability discovered in the device, the Common Vulnerability Scoring System (CVSS) Base score is calculated and the summation of these scores is taken to calculate the total score (for each device). In our experiment, we found that the Tp-Link Smart Bulb and the Tp-Link Smart Camera had the highest score and were the most vulnerable and the Google Home Mini had the least score and was the most secure device of all the devices. Finally, we conclude that our framework does not require technical expertise and thus can be used by common people. This will help improve the field of IoT security and ensure the security of smart homes to build a safe and secure future.
Supplementary figures and tables from Trait variation in extreme thermal environments under constant and fluctuating temperatures
Creators: name: Salinas, Santiago
name: Irvine, Shannon E.
name: Schertzing, Claire L.
name: Golden, Shelby Q.
name: Munch, Stephan B.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Fig S1: Temperature records (from 09/18/2013 to 08/18/2017), recorded in 15-min intervals, from the Lake Superior National Estuarine Research Reserve (Pokegama Bay station [lkspowq], water depth 1-2 m). Note that fathead minnows prefer shallower waters, making the maximum temperatures experienced likely higher than 27-28°C as observed in this plot. Fig S2: Growth trajectories for all fish analyzed in the experiment. Table S1: Model selection results for breakpoint regression analysis of every trait measured vs. temperature. Table S2: Model selection results for breakpoint regression analysis of variance in length-at-age vs. temperature. Table S3: MANOVA results on (a) all of the traits combined, (b) all the length-at-age measurements, (c) all of the morphometric and meristic traits, and (d) all the fluctuating asymmetry (FA) traits. Models = “full”: intercept + temp+fluct+temp*fluct; “no interaction”: intercept + temp+fluct; “no temp”: intercept + fluct; “no fluct”: intercept + temp.
Studies on cellular- based additive manufacturing panels as enablers of specific stiffness requirements
Creators: name: Castillo Acero, Miguel Á.
name: Martín de la Escalera, Federico
Publisher: name: Zenodo
Year: 2017
Subjects: Clean Sky 2 Joint Undertaking
European Union (EU)
Horizon 2020
HLFC
EASN
Aernnova

description: This presentation describes studies on cellular- based additive manufacturing panels as enablers of specific stiffness requirements. This project has received funding from the Clean Sky 2 Joint Undertaking (JU) under grant agreement CS2-LPA-GAM-2016-2017. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Clean Sky 2 JU members other than the Union. The results, opinions, conclusions, etc. presented in this work are those of the author(s) only and do not necessarily represent the position of the JU; the JU is not responsible for any use made of the information contained herein.
(1540) Robert Hutton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An Empirical Analysis of Rice Exports Using the Export Supply Function: The Case of Major Rice Exporting Countries
Creators: name: Kang, Hyunsoo
name: Kang, Hyunsoo
Publisher: name: Unknown
Year: 2005
Subjects: subject: International Relations/Trade
subject: rice exports
subject: economic growth
subject: foreign direct investment

description: The paper analyzes the relationship between rice exports and economic growth for the world's top four exporting countries (Thailand, Vietnam, India, and U.S.). The main objective of this paper is to determine to what extent economic growth impacts the countries’ rice export. The three stage least squares method is used to estimate the simultaneous relationship between the rice export and the economic growth. Results show that the elasticity of rice export price on export volume is shown be inelastic, and economic growth of major rice exporting countries have contribute to increase of rice export volume.
(1541) Elizabeth [Hutton]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Origin of Strong Dispersion in Hubbard Insulators
Creators: name: Wang, Yao
name: Wohlfeld, Krzysztof
name: Moritz, Brian
name: Jia, Chunjing
name: van Veenendaal, Michel
name: Wu, Kai
name: Chen, Cheng-Chien
name: Devereaux, Thomas P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using cluster perturbation theory, we explain the origin of the strongly dispersive feature found at high binding energy in the spectral function of the Hubbard model. By comparing the Hubbard and $t\small{-}J\small{-} 3s$ model spectra, we show that this dispersion does not originate from either coupling to spin fluctuations ($\propto\! J$) or the free hopping ($\propto\! t$). Instead, it should be attributed to a long-range, correlated hopping $\propto\! t^2/U$, which allows an effectively free motion of the hole within the same antiferromagnetic sublattice. This origin explains both the formation of the high energy anomaly in the single-particle spectrum and the sensitivity of the high binding energy dispersion to the next-nearest-neighbor hopping $t^\prime$.
description: 8 pages, 6 figures
Ca 2+ /Calmodulin Directly Interacts with the Pleckstrin Homology Domain of AKT1
Creators: name: Dong, Biao
name: Liu, Rihe
name: Valencia, C. Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: AKT kinase, also known as protein kinase B, is a key regulator of cell growth, proliferation, and metabolism. The activation of the AKT signaling pathway is one of the most frequent molecular alterations in a wide variety of human cancers. Dickson and coworkers recently observed that Ca(2+).calmodulin (Ca(2+).CaM) may be a common regulator of AKT1 activation (Deb, T. B., Coticchia, C. M., and Dickson, R. B. (2004) J. Biol. Chem. 279, 38903-38911). In our efforts to scan the mRNA-displayed proteome libraries for Ca(2+).CaM-binding proteins, we found that both human and Caenorhabditis elegans AKT1 kinases bound to CaM in a Ca(2+)-dependent manner (Shen, X., Valencia, C. A., Szostak, J., Dong, B., and Liu, R. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 5969-5974 and Shen, X., Valencia, C. A., Gao, W., Cotten, S. W., Dong, B., Chen, M., and Liu, R. (2007) submitted for publication). Here we demonstrate that Ca(2+).CaM and human AKT1 were efficiently co-immunoprecipitated, and their interaction was direct rather than mediated by other proteins. The binding is in part attributed to the first 42 residues of the pleckstrin homology (PH) domain, a region that is critical for the recognition of its lipid ligands. The PH domain of human AKT1 can disrupt the complex of the full-length AKT1 with Ca(2+).CaM. In addition, Ca(2+).CaM competes with phosphatidylinositol 3,4,5-trisphophate for interaction with the PH domain of human AKT1. Our findings suggest that Ca(2+).CaM is directly involved in regulating the functions of AKT1, presumably by releasing the activated AKT1 from the plasma membrane and/or prohibiting it from re-association with phosphoinositides on plasma membrane.
Supplemental Figure 1 from Transgenerational effects of parental light environment on progeny competitive performance and lifetime fitness.
Creators: name: Baker, Brennan H.
name: Sultan, Sonia E.
name: Lopez-Ichikawa, Maya
name: Waterman, Robin
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: Genotypic variation for competitive performance of target plants grown in competitive arrays. Genotypic means ± s.e. are shown for (a) the effect of the target plant's Parental Treatment (Sun vs Shade) on its own reproductive output (competitive response, pooled across both background parental treatments); and (b) the effect of the background plants' Parental Treatment (Sun vs Shade) on the target plant's reproductive output (competitive effect; pooled across both target plant parental treatments). Significance tests are shown for the effect of Parental Shade versus Parental Sun on each genotype (Simple Effects Tests; † p < 0.10, **p < 0.01, ***p < 0.001, ns p ≥ 0.10. Details in Methods).
Chaperone Functions of the E3 Ubiquitin Ligase CHIP
Creators: name: Cyr, Douglas M.
name: Patterson, Cam
name: Rosser, Meredith F.N.
name: Washburn, Erin
name: Muchowski, Paul J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The carboxyl terminus of the Hsc70-interacting protein (CHIP) is an Hsp70 co-chaperone as well as an E3 ubiquitin ligase that protects cells from proteotoxic stress. The abilities of CHIP to interact with Hsp70 and function as a ubiquitin ligase place CHIP at a pivotal position in the protein quality control system, where its entrance into Hsp70-substrate complexes partitions nonnative proteins toward degradation. However, the manner by which Hsp70 substrates are selected for ubiquitination by CHIP is not well understood. We discovered that CHIP possesses an intrinsic chaperone activity that enables it to selectively recognize and bind nonnative proteins. Interestingly, the chaperone function of CHIP is temperature-sensitive and is dramatically enhanced by heat stress. The ability of CHIP to recognize nonnative protein structure may aid in selection of slow folding or misfolded polypeptides for ubiquitination.
Supplemental Figure 2 from Transgenerational effects of parental light environment on progeny competitive performance and lifetime fitness.
Creators: name: Baker, Brennan H.
name: Sultan, Sonia E.
name: Lopez-Ichikawa, Maya
name: Waterman, Robin
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: Effects of Parental Sun vs Parental Shade on height extension over time for plants grown in three contrasting offspring treatments, (a) Severe Shade; (b) Neighbor Shade; (c) Sunny Dry. Means ± s.e. are shown (pooled across 5 genotypes). The parental treatment effect varied significantly over time (Parental Treatment x Time interaction term, multivariate repeated-measures ANOVA) in the Sunny Dry offspring treatment (p = 0.039) but was marginally nonsignificant in Severe Shade (p = 0.074) and nonsignificant in Neighbor Shade (p = 0.269), where extension curves over time are nearly parallel. Significance tests are shown for the effect of Parental Shade versus Parental Sun on in each Offspring Treatment (Simple Effects Tests; † p < 0.10, *p < 0.05, **p < 0.01. Details in Methods).
(1537) Walter Bernard Hutton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain α7A and Influences Myoblast Differentiation
Creators: name: Wixler, Viktor
name: Will, Carola
name: Knoblauch, Alexander
name: Von Der Mark, Klaus
name: Samson, Thomas
name: Burridge, Keith
name: Sharek, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Integrin alpha7beta1 is the major laminin binding integrin receptor of muscle cells. The alpha7 chain occurs in several splice isoforms, of which alpha7A and alpha7B differ in their intracellular domains only. The fact that the expression of alpha7A and alpha7B is tightly regulated during skeletal muscle development suggests different and distinct roles for both isoforms. However, so far, functional properties and interacting proteins were described for the alpha7B chain only. Using a yeast two-hybrid screen, we have found that Def-6, a guanine nucleotide exchange factor for Rac1, binds to the intracellular domain of the alpha7A subunit. The specificity of the Def-6-alpha7A interaction has been shown by direct yeast two-hybrid binding assays and coprecipitation experiments. This is the first description of an alpha7A-specific and -exclusive interaction, because Def-6 did not bind to any other tested integrin cytoplasmic domain. Interestingly, the binding of Def-6 to alpha7A was abolished, when cells were cotransfected with an Src-related kinase, which is known to phosphorylate Def-6 and stimulate its exchange activity. We found expression of Def-6 was not only restricted to T-lymphocytes as described thus far but in a more widespread manner, including different muscle tissues. In cells, Def-6 is seen in newly forming cell protrusions and focal adhesions, and its localization partially overlaps with the alpha7A integrin receptor. C2C12 myoblasts overexpressing Def-6 show a delay of Rac1 inactivation during myogenic differentiation and abnormal myotube formation. Thus, our data suggest a role for Def-6 in the fine regulation of Rac1 during myogenesis with the integrin alpha7A chain guiding this regulation in a spatio-temporal manner.
The QCD Dynamics of Tetraquark Production
Creators: name: Brodsky, Stanley J.
name: Lebed, Richard F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We use the twist dimensions of the operators underlying the dynamical behavior of exclusive production processes as a tool for determining the structure of exotic heavy-quark states such as the $Z_c^+(4430)$ tetraquark. The resulting counting rules predict distinctive fall-offs of the cross sections in center-of-mass energy, thus distinguishing whether the tetraquarks are segregated into di-meson molecules, diquark-antidiquark pairs, or more democratically arranged four-quark states. In addition, we propose straightforward methods of experimentally producing additional exotic multiquark states.
description: 7 pages, no figures, REVTeX. Corrects minor typos present in published version