cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The variable OVIII Warm Absorber in MCG-6-30-15
Creators: name: Otani, C.
name: Kii, T.
name: Reynolds, C. S.
name: Fabian, A. C.
name: Iwasawa, K.
name: Hayashida, K.
name: Inoue, H.
name: Kunieda, H.
name: Makino, F.
name: Matsuoka, M.
name: Tanaka, Y.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a 4 day ASCA observation of the Seyfert galaxy MCG-6-30-15, focussing on the nature of the X-ray absorption by the warm absorber, characterizd by the K-edges of the intermediately ionized oxygen, OVII and OVIII. We confirm that the column density of OVIII changes on a timescale of $\sim 10^4$~s when the X-ray continuum flux decreases. The significant anti-correlation of column density with continuum flux gives direct evidence that the warm absorber is photoionized by the X-ray continuum. From the timescale of the variation of the OVIII column density, we estimate that it originates from gas within a radius of about $10^{17}\cm$ of the central engine. In contrast, the depth of the OVII edge shows no response to the continuum flux, which indicates that it originates in gas at larger radii. Our results strongly suggest that there are two warm absorbing regions; one located near or within the Broad Line Region, the other associated with the outer molecular torus, scattering medium or Narrow Line Region.
description: 8 pages (including figures) uuencoded gziped PS file. Submitted to Publications of the Astronomical Society of Japan
On the Heegaard Floer homology of Dehn surgery and unknotting number
Creators: name: Gibbons, Julian Charles
Publisher: name: Imperial College London
Year: 2013

description: n this thesis we generalise three theorems from the literature on Heegaard Floer homology and Dehn surgery: one by Ozsv ́ath and Szab ́o on deficiency symmetries in half-integral L -space surgeries, and two by Greene which use Donaldson’s diagonali- sation theorem as an obstruction to integral and half-integral L -space surgeries. Our generalisation is two-fold: first, we eliminate the L -space conditions, opening these techniques up for use with much more general 3-manifolds, and second, we unify the integral and half-integral surgery results into a broader theorem applicable to non- zero rational surgeries in S 3 which bound sharp, simply connected, negative-definite smooth 4-manifolds. Such 3-manifolds are quite common and include, for example, a huge number of Seifert fibred spaces. Over the course of the first three chapters, we begin by introducing background material on knots in 3-manifolds, the intersection form of a simply connected 4- manifold, Spin- and Spin c -structures on 3- and 4-manifolds, and Heegaard Floer ho- mology (including knot Floer homology). While none of the results in these chapters are original, all of them are necessary to make sense of what follows. In Chapter 4, we introduce and prove our main theorems, using arguments that are predominantly algebraic or combinatorial in nature. We then apply these new theorems to the study of unknotting number in Chapter 5, making considerable headway into the extremely difficult problem of classifying the 3-strand pretzel knots with unknotting number one. Finally, in Chapter 6, we present further applications of the main theorems, ranging from a plan of attack on the famous Seifert fibred space realisation problem to more biologically motivated problems concerning rational tangle replacement. An appendix on the implications of our theorems for DNA topology is provided at the end.
Additional file 1 of Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10
Creators: name: Chugh, Rishi Man
name: Park, Hang-soo
name: El Andaloussi, Abdeljabar
name: Elsharoud, Amro
name: Esfandyari, Sahar
name: Ulin, Mara
name: Bakir, Lale
name: Aboalsoud, Alshimaa
name: Ali, Mohamed
name: Ashour, Dalia
name: Igboeli, Prosper
name: Ismail, Nahed
name: McAllister, Jan
name: Al-Hendy, Ayman
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Human bone marrow mesenchymal stem cells (BM-hMSC) characterization. Figure S2. BM-hMSC decrease expression of steroidogenesis genes in Forskolin-treated human PCOS theca cells. Figure S3. Timeline for in vivo experimental design. Figure S4. BM-hMSC reverse brown fat tissue phenotype in the LTZ-induced PCOS mouse. Figure S5. BM-hMSC reverse adipose tissue adipokines in LTZ-induced PCOS mouse model. Figure S6. Hormonal analysis in the LTZ-induced PCOS mouse model. Figure S7. The effect of BM-hMSC on the endometrium in the LTZ-induced PCOS mouse model. Figure S8. Effect of BM-hMSC secretome injection on the ovary, white fat, brown fat, and fertility in the LTZ-induced PCOS mouse model. Figure S9. Raw data image of Western blot membranes. Table S1. List of Primers.
Alcedo erithaca Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Coraciiformes
Alcedinidae
Alcedo
Alcedo erithaca

description: Alcedo erithaca [spec. nov.]
A. brachyura, dorso caeruleo, abdomine luteo, capite uropygioque purpureo, gula nuchaque albis.
Alcedo benghalensis. Alb. av. 3. p. 28. t. 29.
Habitat in Benghala.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 115, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Nucleosynthesis in Type II supernovae and the abundances in metal-poor stars
Creators: name: Nakamura, Takayoshi
name: Umeda, Hideyuki
name: Nomoto, Ken'ichi
name: Thielemann, Friedrich-Karl
name: Burrows, Adam
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We explore the effects on nucleosynthesis in Type II supernovae of various parameters (mass cut, neutron excess, explosion energy, progenitor mass) in order to explain the observed trends of the iron-peak element abundance ratios ([Cr/Fe], [Mn/Fe], [Co/Fe] and [Ni/Fe]) in halo stars as a function of metallicity for the range $ -4 \le$ [Fe/H] $\le -2.5$. [Cr/Fe] and [Mn/Fe] decrease with decreasing [Fe/H], while [Co/Fe] behaves the opposite way and increases. We show that such a behavior can be explained by a variation of mass cuts in Type II supernovae as a function of progenitor mass, which provides a changing mix of nucleosynthesis from an alpha-rich freeze-out of Si-burning and incomplete Si-burning. This explanation is consistent with the amount of ejected $^{56}$Ni determined from modeling the early light curves of individual supernovae. We also suggest that the ratio [H/Fe] of halo stars is mainly determined by the mass of interstellar hydrogen mixed with the ejecta of a single supernova which is larger for larger explosion energy and the larger Strömgren radius of the progenitor.
description: 17 pages, LaTeX, Accepted for publication in the Astrophysical Journal, more discussion on the Galactic chemical evolution
Shear sound of two-dimensional Fermi liquids
Creators: name: Khoo, Jun Yong
name: Villadiego, Inti Sodemann
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the appearance of a sharp collective mode which features transverse current fluctuations within the bosonization approach to interacting two-dimensional Fermi liquids. This mode is analogous to the shear sound modes in elastic media, and, unlike the conventional zero sound mode, it is damped in weakly interacting Fermi liquids and only separates away from the particle-hole continuum when the quasiparticle mass becomes twice the transport mass $m^* \gtrsim 2 m$. The shear sound should be present in a large class of interacting charged and neutral Fermi liquids especially those proximate to critical points where the quasiparticle mass diverges. In metals this mode remains linearly dispersing in the presence of the long-ranged Coulomb force, unlike the conventional zero sound mode which becomes the plasma mode. We also detail a quick path between bosonization and classical Landau's Fermi liquid theory by constructing a mapping between the solutions of the classical kinetic equation and the quantized bosonic eigenmodes. By further mapping the kinetic equation into a 1D tight-binding model we solve for the entire spectrum of collective and incoherent particle-hole excitations of Fermi liquids with non-zero $F_0$ and $F_1$ Landau parameters.
description: 11 pages, 5 figures
Spatial goal-based error estimation and adaptive mesh refinement (AMR) for diamond difference discrete ordinate (DD-SN) methods
Creators: name: Jeffers, Rebecca Siân
Publisher: name: Imperial College London
Year: 2016

description: A derivation of the dual weighted residual (DWR) goal-based error estimator is given for the 1-D DD-SN discretisation of the fixed source and eigenvalue neutron transport equations. The quantity of interest (QoI) is linear and non-linear respectively. Isotropic scattering is assumed. Error correction and adaptive mesh refinement (AMR) were implemented for the 1-D code to reduce the error in the QoI as a function of the number of degrees of freedom (DoF) required for the forward solution. Higher order DD methods in the 1-D code allowed for h, p and hp AMR. Cell-wise DWRs were used to select cells for refinement. In the hp case, a merit function was used to choose between h or p refinement for a given cell. The extension of the weighted residual (WR) view of the traditional 1-D DD-SN equations to multidimensions results in a bilinear/trilinear approximation within the cell and cell vertex values as unknowns. However, traditional DD codes express the unknowns as cell-average and cell-edge average fluxes. The bilinear and trilinear components of the flux within a cell cannot be recovered from these values for use in the DWR calculation. Two 2-D codes were written, one keeping the cell-vertex values as unknowns and the other implementing the traditional DD scheme. In the former the DWR is calculated as in the 1-D case. The flux result of the latter is mapped into a discontinuous finite element space with a zero bilinear term before calculating the DWR. The vertex code provided the best error estimates. The DWR error estimate had, in general, the same convergence rate as the reference error, though the effectivity index tended towards unity only for fixed source problems with high scatter ratios. The equivalence between the vertex method and the traditional DD method means that the SPN acceleration scheme used by EDF can still be applied.
On Self-Similar Global Textures in an expanding Universe
Creators: name: Åminneborg, Stefan
name: Bergström, Lars
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We discuss self-similar solutions to $O(4)$ textures in Minkowski space and in flat Friedmann-Robertson-Walker backgrounds. We show that in the Minkowski case there exist no solutions with winding number greater than unity. However, we find besides the known solution with unit winding number also previously unknown solutions corresponding to winding number less than one. The validity of the non-linear sigma model approximation is discussed. We point out that no spherically symmetric exactly self-similar solutions exist for radiation or matter dominated FRW cosmologies, but we find a way to relax the assumptions of self-similarity that give us approximative solutions valid on intermediate scales.
description: 12 pages (LaTeX) + 1 postscript figure. To appear in Phys. Lett B
A Sample-oriented Catalogue of BL Lacertae Objects
Creators: name: Padovani, Paolo
name: Giommi, Paolo
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a catalogue of 233 BL Lacertae objects compiled through an extensive bibliographic search updated to mid-1995. A large fraction of the sources listed in the catalogue belongs to well-defined samples and can be used for statistical purposes. A smaller fraction consists of miscellaneous (but confirmed) BL Lacs and of objects classified as BL Lac candidates. We discuss the selection criteria of the different samples, report the discovery of two previously unnoticed BL Lacs in the Palomar-Green survey, and comment on the possible association of some of the still unidentified high galactic latitude gamma-ray (EGRET) sources with BL Lacs. Some statistical properties of the catalogue are also briefly discussed.
description: To appear in MNRAS, 7 pages, uses mn.tex. Two figures, table in TeX and ASCII format, and macro available at http://itovf2.roma2.infn.it/padovani/catalogue.html
Bacterial chemotaxis: from information processing to behaviour
Creators: name: Micali, Gabriele
Publisher: name: Imperial College London
Year: 2016

description: Chemotaxis allows flagellated bacteria to navigate in complex chemical environments, following nutrients and escaping toxins. The sensory system made up of chemoreceptors is constantly monitoring the extracellular concentrations of nutrients and toxins, while the signalling pathway processes and transmits the external information to the flagellated motors for movement. In the case of Escherichia coli, the chemotaxis pathway has been extensively characterised experimentally using genetics, biochemistry, and a wide range of imaging tools. This makes E. coli an ideal model organism for quantitative analysis and modelling. Several remarkable properties of the E. coli chemotaxis pathway have been summarised in terms of design principles. However, the swimming behaviour remains poorly understood, even for genetically identical cells in the artificial conditions normally used in a laboratory. Here, I propose an interdisciplinary approach, which combines theory, computational simulations, and experimental data from my collaborators, to study E. coli chemotaxis from an information-theoretic point of view. I demonstrate that the E. coli chemotaxis pathway is designed to optimally transmit environmental information over a certain range of concentrations and gradients. To do so, I develop a theory that identifies both the responses and the environmental conditions that transmit maximal environmental in- formation. Interestingly, when maximal information is transmitted, the behaviour characterised in terms of the drift velocity towards the nutrient is also maximised. A new design principle is proposed: maximal information transmission leads to maximal drift. Furthermore, the energetic cost of chemotaxis is much lower than the energy consumed to maintain the biological signalling pathway. Hence, thermodynamics does not seem to set constraints on information transmission and drift. However, to fully capitalise on my results, a closer connection with single-cell experiments is suggested.
Additional file 11 of Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype
Creators: name: Chernyakov, Dmitry
name: Groß, Alexander
name: Fischer, Annika
name: Bornkessel, Nicola
name: Schultheiss, Christoph
name: Gerloff, Dennis
name: Edemir, Bayram
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11: Figure S6. (A) RT-PCR of different RCC cell lines for RANBP3L and GAPDH. The cell lines were incubated in isoosmolar or hyperosmolar medium before RNA isolation. As a control normal kidney tissue and GAPDH was used. (B) Immunofluorescence images of different RCC cell lines showing NFAT5 nuclear translocation under hyperosmolar cultivation. Scale bar: 100 μm.
Constraints on a soft X-ray excess in the quasar 3C 279
Creators: name: Lawson, A. J.
name: McHardy, I. M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a three-week daily monitoring campaign on the quasar 3C 279 by the X-ray satellites RXTE and ROSAT. A cross correlation provides no evidence for any time lag between the very similar soft and hard X-ray light curves, and the source shows no significant spectral variability over the observing period. There is no evidence to support the presence of a soft excess, with a 99 per cent upper limit on any such component of 25 per cent of the total observed luminosity in the 0.1-2 keV band (< 3 x 10^38 W). This fraction (but not the luminosity) is significantly less than that of the soft excess observed in 3C 273.
description: 4 pages, 3 figures, accepted for publication in MNRAS. Style files needed: epsf, mn.sty and new_cite.sty (this last is included in submission)
Alcedo alcyon Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Coraciiformes
Alcedinidae
Alcedo
Alcedo alcyon

description: Alcedo alcyon [spec. nov.]
A. brachyura nigra, abdomine albo, pectore ferrugineo.
Alcyon. Catesb. car. 1. p. 69. t. 69. Raj. av. 49. n. 2. & 184. n. 14.
Ispida caroliniensis. Edw. av. 115. t. 115.
Jaguacati guacu. Marcgr. bras. 194.
Habitat in America.
Rostrum capite longius, validum s. Picae. Macula alba ante & post oculos. Lingua brevissima, carnosa, acuta, plana. Corpus nigrum. Pennae capitis longiores. Remiges nigrae, apice albae: exterioribus minoribus; omnes latere interiore albo maculatae. Rectrices 12, aequales, utrinque albo maculatae. Gula alba. Pectus & Abdomen alba, sed Pectus antice fascia ferruginea. Femora ferruginea. Tibiae brevissimae. Digitus extimus connexus cum intermedio.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on pages 115-116, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
The Cluster Distribution as a Test of Dark Matter Models. III. the Cluster Velocity Field
Creators: name: Moscardini, Lauro
name: Branchini, Enzo
name: Brunozzi, Paolo Tini
name: Borgani, Stefano
name: Plionis, Manolis
name: Coles, Peter
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the large-scale velocity fields traced by galaxy clusters in numerical simulations of a box of side 960 $h^{-1}$ Mpc, and compare them with available data on real clusters. In order to test the reliability of the simulations, which are based on an optimized version of the Zel'dovich approximation, we compare their cluster velocities with those of "exact" N-body simulations, and find a remarkable agreement between the two according to a variety of statistical tests. We analyse Cold Dark Matter models with density parameter in the range $0.2\le Ω_0\le 1$, both with and without the cosmological constant term to provide a flat geometry. We also simulate a Cold+Hot Dark Matter model, with 30% provided by the hot component. Comparison with real data is performed by applying tests based on the cumulative velocity frequency distribution (CVFD) and bulk flow statistics. For the CVFD, we use observational velocity data from different authors. By merging all available data in a combined sample, the CVFD test is able to exclude only open models with $Ω_0\le 0.4$ and flat models with $Ω_0=0.2$. However, the analysis of individual observational samples gives contradictory results; in particular the recent Giovanelli data, which imply much lower velocities (with significantly smaller uncertainties) than the other data, are actually only consistent with the open $Ω_0=0.4$ and the flat $Ω_0=0.2$ models, i.e. the models which are excluded by the other data. Furthermore, CVFD and bulk flow analyses of the Branchini et al. reconstructed velocity data disfavour precisely those models accepted on the grounds of Giovanelli's sample. Finally, we confirm that the Lauer & Postman bulk flow determination is an extremely rare event in the cosmological models we have analysed.
description: 18 pages in Latex using MN.sty + 7 figures in an additional file, submitted to MNRAS
Additional file 6: of Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing
Creators: name: Simonsen, Anita
name: Hansen, Marcus
name: Kjeldsen, Eigil
name: MĂ¸Ller, Peter
name: HindkjĂŚr, Johnny
name: Hokland, Peter
name: Aggerholm, Anni
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Figure S5. Scatter plot of OCI-AML3 chr 13 showing medial q-arm deletion and possible small distal deletion of both 50-cell assay replicates. Scatter plots of replicate allele frequencies reveal known partial chr 13 deletion. Short stretches of loss of heterozygosity, relative to the total number of called variants or size of the chromosome, does not severely affect the distribution of heterozygous variant allele frequencies. This is apparent from both Q-Q plots, frequency comparison to an unrelated bulk sequencing sample and test for normality (Anderson-Darling). (PDF 374 kb)
Epigenetic biomarkers for clinical outcomes and mechanisms driving emergence of drug resistance in ovarian cancer
Creators: name: Passey, Alun
Publisher: name: Imperial College London
Year: 2017

description: Epithelial ovarian cancer (EOC) has a poor prognosis, with a 5 year survival rate of ~40%. A major therapeutic barrier is disease chemoresistant to the standard therapeutic regimen of taxol and platinum. Efficacious therapies in chemoresistant disease, a fuller understanding of the molecular mechanisms driving tumour evolution, and drugs to prevent emergence of chemoresistance are required. Bevacizumab, a VEGF inhibitor approved for second line treatment of recurrent, chemoresistant EOC, requires stratification biomarkers to identify patients who will benefit. We investigated VEGF gene promoter methylation in EOC from ICON7 clinical trial patients. Patients with low VEGF-B methylation showed better overall survival (OS) when treated with standard chemotherapy (HR=2.07(1.23, 3.49), P=0.006) but not bevacizumab (HR=1.77(0.99, 3.15), P=0.05), potentially identifying a patient sub-group which should not be treated with bevacizumab. An association between VEGF-C methylation and progression-free survival (PFS) in ICON7 patients (HR=0.66(0.52, 0.84), P=0.0006) was confounded by stage. ICGC patient samples collected at relapse showed elevated VEGF-C compared to primary presentation. In a CRISPR-generated VEGF-C null EOC model we demonstrated an autocrine mechanism by which VEGF-C deregulation and over-expression may drive EOC stage and metastasis by suppressing anoikis-induced apoptosis and promoting growth in non-adherent conditions. Further, we investigated the role of epigenetics and heterogeneity in acquisition of resistance to platinum-based therapies. Epigenetically defined sub-populations which show a reversibly resistant "drug tolerant" phenotype have been demonstrated to exist in chemosensitive tumour populations of many cancers. We isolated reversibly cisplatin tolerant populations (CTPs) from a cisplatin sensitive EOC cell line A2780, which were re-sensitised by EZH2 and HDAC inhibitors. Epigenomic profiling of these populations revealed heavily H3K27me3-modified chromatin in CTPs, preferentially in non-coding regions of the genome, which we hypothesise as a novel mechanism of tolerance for cisplatin as an initial stage for acquisition of stable resistance.
Ring diagram analysis of near-surface flows in the Sun
Creators: name: Basu, Sarbani
name: Antia, H. M.
name: Tripathy, S. C.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Ring diagram analysis of solar oscillation power spectra obtained from MDI data is carried out to study the velocity fields in the outer part of the solar convection zone. The three dimensional power spectra are fitted to a model which has a Lorentzian profile in frequency and which includes the advection of the wave front by horizontal flows, to obtain the two components of the sub-surface flows as a function of the horizontal wave number and radial order of the oscillation modes. This information is then inverted using OLA and RLS methods to infer the variation in horizontal flow velocity with depth. The average rotation velocity at different latitudes obtained by this technique agrees reasonably with helioseismic estimates made using frequency splitting data. The shear layer just below the solar surface appears to consist of two parts with the outer part up to a depth of 4 Mm, where the velocity gradient does not show any reversal up to a latitude of 60 degrees. In the deeper part the velocity gradient shows reversal in sign around a latitude of 55 degrees. The zonal flow velocities inferred in the outermost layers appears to be similar to those obtained by other measurements. A meridional flow from equator polewards is found. It has a maximum amplitude of about 30 m/s near the surface and the amplitude is nearly constant in the outer shear layer.
description: aastex, 12 figures, to appear in Ap.J
Development of a magneto-optical trap for CaF molecules
Creators: name: Hambach, Moritz
Publisher: name: Imperial College London
Year: 2017

description: Laser cooling and trapping in a magneto-optical trap (MOT) have been essential to the success of cold atom physics in the last decades. Recently, the application of the same techniques to molecules has begun. The complexity of even a simple diatomic molecule makes laser cooling difficult, but promises new applications in many areas of research. In this thesis I describe the development of the first three-dimensional MOT of calcium fluoride (CaF) molecules. First, a cryogenic buffer gas source was set up, producing a pulsed beam of 9.3*10^10 molecules per steradian per pulse with forward velocities around 170 m/s. A similar source for very large molecules was set up during a 5 month internship at the University of Vienna. Next, the molecular pulse was slowed down to the capture velocity of a MOT using chirped laser slowing, resulting in about 7*10^5 CaF molecules passing through the typical MOT volume of 1 cm^3 at velocities of 15+-5 m/s. A new deceleration method, called Zeeman-Sisyphus deceleration, was also investigated. In this method molecules move through a spatially varying magnetic field and are optically pumped between low- and high-field seeking states in such as a way that they are always losing kinetic energy. The method promises to deliver more slow molecules because the molecules are guided transversely as they are decelerated. A small prototype was built and the optical pumping step was tested successfully. Finally, 7.6*10^3 CaF molecules were trapped in a MOT and cooled to a temperature of 8.5 mK. The radial trap frequency is 2 pi*130 Hz and the damping constant is beta=9.5*10^2 s^-1. The lifetime is about 100 ms and depends strongly on the scattering rate. This MOT is an an ideal starting point for a wide range of new experiments with ultracold molecules.
Electric dipole moments and dark matter in a CP violating MSSM
Creators: name: Abe, Tomohiro
name: Omoto, Naoya
name: Seto, Osamu
name: Shindou, Tetsuo
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate electric dipole moments (EDMs) in a CP-violating minimal supersymmetric standard model with the Bino-like neutralino dark matter (DM) annihilating through the heavy Higgs funnel. Motivated by the current experimental results, in particular, the measured mass of the standard model-like Higgs boson, we consider a mass spectrum with stop masses of about 10 TeV. For the other sfermions, we consider masses of about 100 TeV. We show that CP-violating phases of the order of ten degrees in gaugino and Higgsino mass parameters are consistent with the current bound by EDMs of the electron, the neutron, and the mercury. They are within the reach of future experiments. We also show that effects of CP-violating phases induce a difference in DM-nucleon scattering cross section by a factor.
description: 21pages, 9 figures, the version published in PRD
The distribution of pairwise peculiar velocities in the nonlinear regime
Creators: name: Sheth, Ravi K.
name: Berkeley, U. C.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The distribution of pairwise, relative peculiar velocities, $f(u;r)$, on small nonlinear scales, $r$, is derived from the Press--Schechter approach. This derivation assumes that Press--Schechter clumps are virialized and isothermal. The virialized assumption requires that the circular velocity, $V_c \propto M^{1/3}$, where $M$ denotes the mass of the clump. The isothermal assumption means that the circular velocity is independent of radius. Further, it is assumed that the velocity distribution within a clump is Maxwellian, that the pairwise relative velocity distribution is isotropic, and that on nonlinear scales clump-clump motions are unimportant when calculating the distribution of velocity differences. Comparison with $N$-body simulations shows that, on small nonlinear scales, all these assumptions are accurate. For most power spectra of interest, the resulting line of sight, pairwise, relative velocity distribution, $f(u_{\rm r})$, is well approximated by an exponential, rather than a Gaussian distribution. This simple Press--Schechter model is also able to provide a natural explanation for the observed, non-Maxwellian shape of $f(v)$, the distribution of peculiar velocities.
description: (MNRAS, in press) 16 pages, uuencoded
The effect of Poly I:C induced inflammation on hematopoietic stem and progenitor cell behaviour in the zebrafish hematopoietic transplant model
Creators: name: McBrien, Marie
Publisher: name: Imperial College London
Year: 2017

description: Hematopoietic stem cells are a small but significant population of cells fundamental for generating and maintaining the hematopoietic system. These cells are used in the treatment of cancer and auto-immune patients. Studies in mammals suggest that inflammation and infection can modulate the biology of these cells, affecting their location, self-renewal capacity and directing differentiation. The aim of this work was to study the effect of repeated stimulation on the hematopoietic stem and progenitor (HSPCs) population in zebrafish (Danio rerio) to benefit from the live imaging potential of this model organism. It was hypothesised that early post-transplant HSPC behaviour (e.g. lodgement in the niche, self-renewal, mobilisation and differentiation) could be observed and would be indicative of the success or failure of HCT. Double transgenic Tg (cd41:GFP; lysc:dsRed) donors, in which HSPCs express green fluorescent protein (GFP+) and myeloid cells express red fluorescent protein (dsRed+) were used. HSPCs were sorted from donor whole kidney marrow (WKM) and transplanted into irradiated optically-transparent recipients, which were then imaged using wide-field microscopy, individually tracked for survival and hematopoietic reconstitution was assessed after 28 days by flow cytometry. Indeed, initial experiments showed that early observations of cells in the WKM correlated with hematopoietic recovery and survival of recipients, although the strength of the correlation was not sufficiently powerful for predicting recipient outcome. This refinement of the HCT protocol lead to the potentiality of studying the behaviour of HSPCs in the context of inflammation. Inflammation was initiated with repeated intra-peritoneal injections of the viral mimic Polyinosinic:polycytidylic acid (poly I:C) in either the donor or recipient prior to transplant. Poly I:C injection of donors prior to transplant causes HSPCs to colonise the recipient WKM at a greater rate than HSPCs from sham (PBS-injected) donors. However, this did not appear to affect recipient survival or WKM reconstitution at 28 days. Poly I:C injection of recipients prior to transplant did not affect early post-transplant repopulation of the WKM, myelopoiesis, recipient survival, or WKM reconstitution at 28 days. Future work will use competitive transplants to confirm these findings and will explore alternative inflammation models. Furthermore, the confounding factor of irradiation-caused inflammation will be mitigated by transplanting HSPCs into optically-transparent bloodless recipients. Overall, this thesis has demonstrated that the zebrafish can provide valuable in vivo data for studying HSPC behaviour in the recipient post-transplant.
The electrical conductivity tensor of $β$-Ga2O3 analyzed by van der Pauw measurements: Inherent anisotropy, off-diagonal element, and the impact of grain boundaries
Creators: name: Golz, Christian
name: Hortelano, Vanesa
name: Hatami, Fariba
name: Masselink, W. Ted
name: Galazka, Zbigniew
name: Bierwagen, Oliver
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The semiconducting oxide $β$-Gallium Oxide ($β$-Ga$_{2}$O$_{3}$) possesses a monoclinic unit cell whose low symmetry generally leads to anisotropic physical properties. For example, its electrical conductivity is generally described by a polar symmetrical tensor of second rank consisting of four independent components. Using van der Pauw measurements in a well-defined square geometry on differently-oriented high-quality bulk samples and the comparison to finite element simulations we precisely determine the ratio of all elements of the $β$-Ga$_{2}$O$_{3}$ 3-dimensional electrical conductivity tensor. Despite the structural anisotropy a nearly isotropic conductivity at and above room temperature was found with the principal conductivities deviating from each other by less than 6% and the off-diagonal element being $\approx3$% of the diagonal ones. Analysis of the temperature dependence of the anisotropy and mobility of differently doped samples allows us to compare the anisotropy for dominant phonon-scattering to that for dominant ionized-impurity scattering. For both scattering mechanisms, the conductivites along the $a$ and $b$-direction agree within 2%. In contrast, the conductivity along $c$-direction amounts to $0.96\times$ and up to $1.12\times$ that along the $b$-direction for phonon and ionized impurity scattering, respectively. The determined transport anisotropies are larger than the theoretically predicted effective mass anisotropy, suggesting slightly anisotropic scattering mechanisms. We demonstrate that significantly higher anisotropies can be caused by oriented extended structural defects in the form of low-angle grain boundaries for which we determined energy barriers of multiple 10 meV.
VLA Observations of Ultraluminous IRAS Galaxies: Active Nuclei or Starbursts?
Creators: name: Crawford, Thomas
name: Marr, Jon
name: Partridge, Bruce
name: Strauss, Michael
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We employed the Very Large Array (VLA) of the National Radio Astronomy Observatory in C configuration to map 39 ultraluminous IRAS galaxies at 6~cm and 20~cm, at resolutions of ~ 4" and 15", respectively, and 24 sources at 6~cm with in the A configuration with a resolution of ~0.5". Most of the sources have radio spectral indices indicative of synchrotron emission (alpha ~ -0.65). There is one source, however, that shows an inverted spectrum with alpha = +2.1; observations at higher frequencies show that the spectrum peaks between 5 and 8 GHz, as high as any of the ``gigahertz peaked spectrum'' sources studied by O'Dea etal. We discuss the implications of this source for observations of fluctuations in the CMB. Two of the sources show multiple unresolved components, another four are doubles with at least one resolved component, 14 show extended emission which could arise from a disk, and two show arc-second long jets. Our data fit the tight correlation found by Helou etal (1985) between far-infrared and microwave luminosity; this correlation extends to the highest infrared luminosities. The correlation is weaker if only the extended or the nuclear components of the radio luminosity are used. Therefore the far-infrared emission in the majority of these higher luminosity galaxies is due to the same mechanism as the lower luminosity FIR sources, which is believed to be star formation, rather than non-thermal activity in the nucleus. Moreover, the star formation is not confined to the extended disk in these sources, but is important in the nucleus as well.
description: In press, Astrophysical Journal. 34 pages, uuencoded gzip'ed postscript of text, tables and figures. 3 figures not included; contact Margaret Best at best@ias.edu for hardcopies of these
Funding intervention projects in the water and sanitation sector: success by design
Creators: name: Al-Awar, Aida
Publisher: name: Imperial College London
Year: 2017

description: This thesis aims to evaluate the role of overseas development assistance in the delivery of water and sanitation related MDGS from a systems perspective, in order to deliver a more coherent framework that seeks to reduce developing countries’ water and sanitation needs. To achieve this, an assessment of the delivery of water and sanitation related MDGs is conducted and the main causes of concern are identified. From these, funding was isolated for further exploration, as it underpins and influences the other issues. The role and extent to which funding drives the delay in the completion of the water and sanitation MDGs is investigated on a regional level from a systems perspective, looking at the funding mechanisms as a whole. A set of hypotheses accounting for the hindrance of the MDG is determined. To test said hypothesis, the part and degree to which funding mechanisms drive the delay in completing the water and sanitation MDG on a national scale is explored using the countries in Sub-Saharan Africa as a case study. The evaluation pinpoints a series of findings recognized as root causes for the lag in the achievement of the water and sanitation MDG. Once the root causes and main areas of concern are identified and the current system is understood, a solution that answers the issues is proposed and a coherent framework that aims to reduce developing countries’ water and sanitation needs is developed. Based on better funding practices, a Needs Based Approach is recognized as a resolution that addresses all the problems.
Disk Formation In Hierarchical Hydrodynamical Simulations: A Way Out Of The Angular Momentum Catastrophe
Creators: name: Dominguez-Tenreiro, R.
name: Tissera, P. B.
name: Saiz, A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report results on the formation of disk-like structures in two cosmological hydrodynamical simulations in a hierarchical clustering scenario, sharing the same initial conditions. In the first one, a simple and generic implementation of star formation has allowed galaxy-like objects with stellar bulges and extended, populated disks to form. Gas in the disk comes from both, particles that survive mergers keeping in part their angular momentum content, and new gas supply by infall, once the merger process is over, with global specific angular momentum conservation. The stellar bulge forms from gas that has lost most of its angular momentum. In the second simulation, no star formation has been included. In this case, objects consist of an overpopulated central gas concentration, and an extended, underpopulated disk. The central concentration forms from particles that suffer an important angular momentum loss in violent events, and it often contains more than 70% of the object's baryonic mass. The external disk forms by late infall of gas, that roughly conserves its specific angular momentum. The difference between these two simulations is likely to be due to the stabilizing character of the stellar bulge-like cores that form in the first simulation, which diminishes the inflow of gas triggered by mergers and interactions.
description: 11 pages, 2 figures. Accepted by The Astrophysical Journal Letters
Additional file 10 of Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype
Creators: name: Chernyakov, Dmitry
name: Groß, Alexander
name: Fischer, Annika
name: Bornkessel, Nicola
name: Schultheiss, Christoph
name: Gerloff, Dennis
name: Edemir, Bayram
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 10: Figure S5. (A) Mean log2 expression of NFAT5 in all TCGA RCC samples compared to normal tissue. Values were analyzed with a student’s-T test and are presented in a whiskers 1–99 percentile plot, ***, p<0.001. n = the number of available samples in the indicating TCGA cohort. (B) Among RCC subtypes NFAT5 expression is downregulated in KIRC and KIRP. Values were analyzed with a student’s-T test and are represented in a whiskers 1–99 percentile plot, n.s., p > 0.05, **, p
Additional file 5: of Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing
Creators: name: Simonsen, Anita
name: Hansen, Marcus
name: Kjeldsen, Eigil
name: MĂ¸Ller, Peter
name: HindkjĂŚr, Johnny
name: Hokland, Peter
name: Aggerholm, Anni
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Figure S4. Deterioration of allele frequencies (AF) and copy number signals by decreased cell input. The plots show the median filtered (range of neighborhood was set to 100 variants) allele frequencies (AF). All AFs (replicate mean) below 0.5 was mirrored to the equal distance above for an improved signal-to-noise ratio. While the signal deteriorates for copy gains with smaller cell input, the signal of the deletions does not. (PDF 429 kb)
The propagation delay in the timing of a pulsar orbiting a supermassive black hole
Creators: name: Hackmann, Eva
name: Dhani, Arnab
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The observation of a pulsar closely orbiting the galactic center supermassive black hole would open the window for an accurate determination of the black hole parameters and for new tests of General Relativity. An important relativistic effect which has to be taken into account in the timing model is the propagation delay of the pulses in the gravitational field of the black hole. Due to the extreme mass ratio of the pulsar and the supermassive back hole we use the test particle limit to derive an exact analytical formula for the propagation delay in a Schwarzschild spacetime. We then compare this result to the propagation delays derived in the usually employed post-Newtonian approximation, in particular to the Shapiro delay up to the second post-Newtonian order. For edge-on orbits we also consider modifications of the Shapiro delay which take the lensing effects into account. Our results are then used to assess the accuracy of the different orders of the post-Newtonian approximation of the propagation delay. This comparison indicates that for (nearly) edge-on orbits the new exact delay formula should be used.
description: 13 pages, 5 figures; preprint of the journal version; GRG editor's choice publication
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Cart. 187 (11 H 72), f. 0021r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: LaMOP
subject: Chartes de la Bourgogne du Moyen Âge
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0021r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0021r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 12 of Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype
Creators: name: Chernyakov, Dmitry
name: Groß, Alexander
name: Fischer, Annika
name: Bornkessel, Nicola
name: Schultheiss, Christoph
name: Gerloff, Dennis
name: Edemir, Bayram
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12: Figure S7. (A, C, E) Plot of the wound density over time of 786–0 (A), Caki-1 (C) and Caki-2 (E). Migration assay was performed for 24–48 h. Values represent mean ± SEM (error bars). n = 2–3 (with 2–4 technical replicates). The relative migration change after 8 h (for 786–0) and after 16 h (for Caki-1 and Caki-2) was calculated by linear regression analysis using GraphPad 9 Prism. ***, p < 0.001, Student’s t test. (B, D, F). Proliferation analyzes of 786–0 (B), Caki-1 (D), and Caki-2 (F). Cells were cultivated in 96-well plates and the proliferation was measured by live-cell imaging using the IncuCyte S3 system taking an image every 4 h for 24–48 h. The relative cell density was calculated by IncuCyte S3 software and normalized to the cell density at 0 h. The data points were fitted by nonlinear exponential growth equation using GraphPad Prism to calculate the mean doubling times. Values represent mean ± SEM (error bars). n = 2–3 (with 2 technical replicates), ***, p < 0.001, Student’s t test.