cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells
Creators: name: Spike, Benjamin T.
name: Dravis, Christopher
name: Wahl, Geoffrey M.
name: Harrell, J. Chuck
name: Johns, Claire
name: Trejo, Christy L.
name: Perou, Charles M.
name: Southard-Smith, E. Michelle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SummaryTo discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for fetal and adult mammary development. These analyses identified a signaling axis between FGF signaling and the transcription factor Sox10. Here, we show that Sox10 is specifically expressed in mammary cells exhibiting the highest levels of stem/progenitor activity. This includes fetal and adult mammary cells in vivo and mammary organoids in vitro. Sox10 is functionally relevant, as its deletion reduces stem/progenitor competence whereas its overexpression increases stem/progenitor activity. Intriguingly, we also show that Sox10 overexpression causes mammary cells to undergo a mesenchymal transition. Consistent with these findings, Sox10 is preferentially expressed in stem- and mesenchymal-like breast cancers. These results demonstrate a signaling mechanism through which stem and mesenchymal states are acquired in mammary cells and suggest therapeutic avenues in breast cancers for which targeted therapies are currently unavailable.
Public and Law Enforcement Safety in the Implementation of Red Flag Laws
Creators: name: Taylor, Bruce
name: Weiwei Liu
name: Sheridan-Johnson, Jackie
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Criminology and Criminal Justice
subject: Law Enforcement and Corrections
subject: Legal Studies
subject: Social and Behavioral Sciences
subject: Law
subject: FOS: Law

description: NORC at the University of Chicago conducted 17 interviews with command staff and officers from 10 law enforcement agencies (LEAs) in six states with Extreme Risk Protection Order (ERPO) laws to gain understanding of ERPO implication in LEAs.

We asked four research questions:
RQ1: How do agencies align and vary in the level of support for ERPOs? We examined whether agencies think ERPOs are effective in reducing firearm violence and what kind of firearm violence agencies think ERPOs are most effective in reducing.
RQ2: What are the volumes and practices and their variations? We examined to what extent agencies align and vary in volumes and practices of ERPOs and identified best practices for implementing ERPOs in agencies that implement high volumes.
RQ3: What are the commonalities and differences in terms of ERPO policy and training? We examined the extent to which agencies have formal written policies and training specific to ERPOs.
RQ4: What are some of the common barriers and challenges that LEAs have regarding the implementation of ERPOs?
Vom Bauchgefühl zur Strategie
Creators: name: Vonhof, Cornelia
Publisher: name: Humboldt-Universität zu Berlin, Philosophische Fakultät I, Institut für Bibliotheks- und Informationswissenschaft
Year: 2017
Subjects: subject: Öffentliche Bibliothek
subject: Förderverein
subject: Freundeskreis
subject: Best-Practice-Beispiele
subject: 020 Bibliotheks- und Informationswissenschaft

description: Ohne Partnerschaften, Kooperationen und Netzwerke geht heute fast nichts mehr. Dies gilt für den öffentlichen wie für den privaten Sektor, und es gilt für Bibliotheken aller Größen und Sparten ebenso wie für Fördervereine von Bibliotheken. Wenn dies aber so ist, dann ist es geboten, diese Beziehungen durch ein Partnerschaftsmanagement systematisch und bewusst zu entwickeln und zu pflegen. Der Beitrag stellt Instrumente und Vorgehensweisen für ein Partnerschaftsmanagement vor.
Two Functionally Distinct Sources of Actin Monomers Supply the Leading Edge of Lamellipodia
Creators: name: McMillen, Laura M.
name: Vavylonis, Dimitrios
name: Gomez, Shawn M.
name: Vitriol, Eric A.
name: Zheng, James Q.
name: Kapustina, Maryna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and disassembly into actin monomers (G-actin). Traditionally, G-actin is thought to exist as a homogeneous pool. Here, we show that there are two functionally and molecularly distinct sources of G-actin that supply lamellipodial actin networks. G-actin originating from the cytosolic pool requires the monomer binding protein thymosin β4 (Tβ4) for optimal leading edge localization, is targeted to formins, and is responsible for creating an elevated G/F-actin ratio that promotes membrane protrusion. The second source of G-actin comes from recycled lamellipodia F-actin. Recycling occurs independently of Tβ4 and appears to regulate lamellipodia homeostasis. Tβ4-bound G-actin specifically localizes to the leading edge because it doesn’t interact with Arp2/3-mediated polymerization sites found throughout the lamellipodia. These findings demonstrate that actin networks can be constructed from multiple sources of monomers with discrete spatiotemporal functions.
On the Characterization, Detection and Impact of Batch Refactoring in Practice
Creators: name: Bibiano, Ana Carla
name: Garcia, Alessandro
Publisher: name: Zenodo
Year: 2020
Subjects: batch refactoring
code smel
literature review
internal structural quality

description: Up to 60% of the refactorings in software projects are constituted of a set of interrelated transformations, the so-called batches (or composite refactoring), rather than single transformations applied in isolation. However, a systematic characterization of batch characterization is missing, which hampers the elaboration of proper tooling support and empirical studies of how(batch) refactoring is applied in practice. This paper summarizes the research performed under the context of a Master’s dissertation, which aimed at taming the aforementioned problems. To the best of our knowledge, our research is the first work published that provides a conceptual foundation, detection sup-port, and large impact analysis of batch refactoring on code maintainability. To this end, we performed two complementary empirical studies as well as de-signed a first heuristic aimed at explicitly detecting batch refactorings. Our first study consisted of a literature review that synthesizes the otherwise scattered, partial conceptualization of batch refactoring mentioned in 29 studies with different purposes. We identified and defined seven batch characteristics such as the scope and typology of batches, plus seven types of batch effect on software maintainability, including code smell removal. All batches’ characteristics and possible impacts were systematized in a conceptual framework, which assists, for instance, the proper design of batch refactoring studies and batch detection heuristics. We defined a new heuristic for batch detection, which made it possible to conduct a large study involving 4,607 batches discovered in 57 open and closed software projects. Amongst various findings, we reveal that most batches in practice occur entirely within one commit (93%), affect multiple methods(90%). Surprisingly, batches mostly end up introducing (51%) or not removing (38%) code smells. These findings contradict previous investigations limited to the impact analysis of each transformation in isolation. Our findings also enabled us to reveal beneficial or harmful patterns of batches that respectively induces the introduction or removal of certain code smells. These patterns: (i)were not previously documented even in Fowler’s refactoring catalog, and (ii)provide concrete guidance for both researchers, tool designers, and practitioners.
A Time-parallel Approach to Strong-constraint Four-dimensional Variational Data Assimilation
Creators: name: Rao, Vishwas
name: Sandu, Adrian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: A parallel-in-time algorithm based on an augmented Lagrangian approach is proposed to solve four-dimensional variational (4D-Var) data assimilation problems. The assimilation window is divided into multiple sub-intervals that allows to parallelize cost function and gradient computations. Solution continuity equations across interval boundaries are added as constraints. The augmented Lagrangian approach leads to a different formulation of the variational data assimilation problem than weakly constrained 4D-Var. A combination of serial and parallel 4D-Vars to increase performance is also explored. The methodology is illustrated on data assimilation problems with Lorenz-96 and the shallow water models.
description: 22 Pages
AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function
Creators: name: Stewart, David M.
name: Yang, Ze
name: Jiang, Jun
name: Zhang, Yi
name: Yamane, Kenichi
name: Qi, Shankang
name: Wong, Jiemin
name: Li, Jiwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: LSD1 (KDM1 under the new nomenclature) was the first identified lysine-specific histone demethylase belonging to the flavin-dependent amine oxidase family. Here, we report that AOF1 (KDM1B under the new nomenclature), a mammalian protein related to LSD1, also possesses histone demethylase activity with specificity for H3K4me1 and H3K4me2. Like LSD1, the highly conserved SWIRM domain is required for its enzymatic activity. However, AOF1 differs from LSD1 in several aspects. First, AOF1 does not appear to form stable protein complexes containing histone deacetylases. Second, AOF1 is found to localize to chromosomes during the mitotic phase of the cell cycle, whereas LSD1 does not. Third, AOF1 represses transcription when tethered to DNA and this repression activity is independent of its demethylase activity. Structural and functional analyses identified its unique N-terminal Zf-CW domain as essential for the demethylase activity-independent repression function. Collectively, our study identifies AOF1 as the second histone demethylase in the family of flavin-dependent amine oxidases and reveals a demethylase-independent repression function of AOF1.
(401544) Agnes Ogilvie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Subarachnoid hemorrhage patterns. What the radiologist should know.
Creators: name: Diaz, Israel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Emergency
subject: Neuroradiology brain
subject: CT
subject: CT-Angiography
subject: MR
subject: Education
subject: Aneurysms
subject: Arteriovenous malformations
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Know the patterns of subarachnoid hemorrhage (SaH). Recognize the main findings of each SaH patterns in images. Know important etiologies of each pattern, mainly focused on the cerebral convexity pattern of...
Exact solutions in $\mathcal{R}^{2}$ SUGRA
Creators: name: Cisterna, Adolfo
name: Hassaïne, Mokhtar
name: Oliva, Julio
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: This letter is devoted to show that the bosonic sector of the $\mathcal{R}^{2}$-SUGRA in four dimensions, constructed with the F-term, admits a variety of exact and analytic solutions which include, pp- and AdS waves, asymptotically flat and AdS black holes and wormholes, as well as product spacetimes. The existence of static black holes and wormholes implies that a combination involving the Ricci scalar plus the norm of the field strength of the auxiliary two-form $B_{μν}$, must be a constant. We focus on this sector of the theory which has two subsectors depending on whether such a combination vanishes or not.
description: 11 pages, 1 figure. V2: minor changes and references added. To appear in PRD
Role of H3K27 methylation in the regulation of lncRNA expression
Creators: name: Zhang, Yi
name: Wu, Susan C.
name: Kallin, Eric M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Once thought to be transcriptional noise, large non-coding RNAs (lncRNAs) have recently been demonstrated to be functional molecules. Cell-type specific expression patterns of lncRNAs suggest that their transcription may be regulated epigenetically. Using a custom-designed microarray, here we examine the expression profile of lncRNAs in embryonic stem (ES) cells, lineage-restricted neuronal progenitor cells (NPC), and terminally differentiated fibroblasts. In addition, we also analyze the relationship between their expression and their promoter H3K4 and H3K27 methylation patterns. We find that numerous lncRNAs in these cell types undergo changes in the levels of expression and promoter H3K4me3 and H3K27me3. Interestingly, lncRNAs that are expressed at lower levels in ES cells exhibit higher levels of H3K27me3 at their promoters. Consistent with this result, knockdown of the H3K27me3 methyltransferase Ezh2 results in derepression of these lncRNAs in ES cells. Thus, our results establish a role for Ezh2-mediated H3K27 methylation in lncRNA silencing in ES cells and reveal that lncRNAs are subject to epigenetic regulation in a similar manner to that of protein coding genes.
Supplement
Creators: name: Ratzenberger, Julius
name: Kiseleva, Iuliia
name: Koppitz, Boris
name: Beyreuther, Elke
name: Zahn, Manuel
name: Gössel, Joshua
name: Hegarty, Peter
name: Amber, Zeeshan
name: Rüsing, Michael
name: Eng, Lukas
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Several additional more detailed tables, figures, descriptions
(401538) Dorothy Alberta Albermarle Cator
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
FluidNET abstract - Modelling fluid flow and water-rock interaction in fractured crust using a Discrete Fracture Network approach
Creators: name: Harb, Ibrahim
name: Grandia, Fidel
name: Trinchero, Paolo
name: Hyman, Jeffrey
Publisher: name: Zenodo
Year: 2022

description: Modelling fluid flow and water-rock interaction in fractured crust using a Discrete Fracture Network approach Groundwater accounts for around 25% of the world’s fresh water supply. Due to the increasing anthropogenic pressure on shallow aquifers as well as climate change that is impacting global groundwater recharge, there is an increasing need to access deeper groundwater resources, which are frequently hosted in fractured-rock formations. The migration of groundwater (and other types of fluids, in general) in fractured rocks allows the contact between fluids in geochemical disequilibrium with the host rocks (i.e., large geochemical gradients) promoting water-rock reactions inside the fractures. These reactions may influence the permeability and porosity, as well as they may lead to fracture sealing. So, a thorough understanding of the coupled hydro-chemical processing that occur in fractured media is important for applications such as the sustainable exploitation of the afore-mentioned reserves, the protection and remediations of aquifers used for drinking water production or the safety analyses of deep geological repositories for spent nuclear fuel. In fractured rocks, groundwater flows in specific pathways and interacts with the host rock which may lead to the change in the hydro-geochemical conditions. The prediction of these interactions become critical for a proper management of the different applications. Therefore, the understanding and modelling of fluid-fracture interaction is of high scientific and commercial interest. Using the software dfnWorks, it is possible to model the fluid transport using a non-reactive Lagrangian method (particle tracking). In this contribution, we intend to implement geochemical reactions in dfnWorks to quantify the impact of these reactions in the fracture network. In fact, flow of water through Discrete Fracture Networks leads to interaction between water and the minerals occurring in the fracture plane and thus alters the underlying groundwater flow patterns. Thus, using these DFN-based reactive transport simulations, we aim at predicting the effect that chemical reactions have on flow and channeling. Besides presenting a proof-of-concept set of calculations, we will also present preliminary results of a real-case application, where fracture filling is produced as a result of a chemical imbalance.
title: Role of dynamic cardiac stress CT perfusion for the assessment of significant coronary artery disease: our preliminary experience
Creators: name: Biondo, Andrea
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT-Angiography
subject: Diagnostic procedure
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Computed tomography myocardial perfusion imaging (CTP) is a recently developed CT-based technique that combines anatomical and functional evaluation of coronary artery disease (CAD) in a single imaging modality. Stress CTP allows the assessment of...
title: Learning from Excellence in a multinational healthcare organization
Creators: name: Paraskevopoulou, Chryssa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Management
subject: Conventional radiography
subject: CT
subject: Mammography
subject: Safety
subject: Workforce

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Safety in healthcare has traditionally focused on learning from error. This approach may miss opportunities to learn from excellent practice. Striving for excellence is highly prevalent, however there is often no formal system to capture it. We tend...
Di-photon "Ridge" in p+p and p+A collisions at RHIC and the LHC
Creators: name: Kovner, Alex
name: Rezaeian, Amir H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We obtain prompt di-photon cross-section in proton-nucleus collisions in Hamiltonian light-cone approach within a hybrid approximation, treating the projectile proton in the parton model and the target nucleus in the Color-Glass-Condensate approach. We study in details the di-photon correlations in quark-nucleus and proton-nucleus collisions at RHIC and the LHC. We show that the single fragmentation di-photon produces the away side correlations peak, and the double fragmentation component of prompt di-photon is responsible for the near-side peak, and the long-range in rapidity near-side azimuthal collimation, the so-called "ridge" structure. We study the transverse momentum, density and energy dependence of the di-photon ridge and show that it strongly depends on the kinematics and saturation dynamics. We show that while di-photon ridge exists at the LHC in quark-nucleus collisions, the effect disappears in proton-nucleus collisions at the LHC. At RHIC the ridge-type structure persists at low transverse momenta of di-photon even in proton-nucleus collisions. We argue that di-photon correlation measurments in p+A collisions can help to discriminate among models and understand the true origin of the observed di-hadron ridge in p+A collisions. We also show that in addition to the ridge structure, prompt di-photon correlation also exhibits some distinct novel features, including the emergence of away side double-peak structure at intermediate transverse momenta.
description: 23 pages, 11 figures; v2: results unchanged, a clarifying Appendix added. The version to appear in PRD
Supplementary material from Modelling the anisotropic inelastic response of polymeric scaffolds for in situ tissue engineering applications
Creators: name: Terzano, Michele
name: Wollner, Maximilian P.
name: Kainz, Manuel P.
name: Rolf-Pissarczyk, Malte
name: Götzen, Nils
name: Holzapfel, Gerhard A.
Publisher: name: The Royal Society
Year: 2023
Subjects: Biomechanics
Biomedical Engineering not elsewhere classified

description: Additional derivations and results
title: Allowing machine learning models to say “I don’t know”: Improving automated clinical decision-making by balancing performance against abstention
Creators: name: Wesp, Philipp
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT-Colonography
subject: Experimental investigations
subject: Pathology

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: As machine learning becomes further integrated into the clinical routine, the quantification and communication of uncertainty for individual predictions can lead to an improved decision-making and safe clinical deployment [1]. The purpose of this...
title: Diagnostic imaging of the thoracic outlet syndrome
Creators: name: Sidorova, Julia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Head and neck
subject: Musculoskeletal system
subject: CT
subject: CT-Angiography
subject: Computer Applications-Detection, diagnosis
subject: Congenital
subject: Dysplasias
subject: Hyperplasia / Hypertrophy

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explore the possibilities of computed tomography in diagnosing patients with upper thoracic outlet syndrome (TOS). Describe normal anatomy and major abnormalities of bone and muscular structures of the upper thoracic outlet. To determine the role of...
(401536) Jane Robertson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Measurement of transverse energy-energy correlations in multi-jet events in $pp$ collisions at $\sqrt{s} = 7$ TeV using the ATLAS detector and determination of the strong coupling constant $α_{\mathrm{s}}(m_Z)$
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: High transverse momentum jets produced in pp collisions at a centre of mass energy of 7 TeV are used to measure the transverse energy-energy correlation function and its associated azimuthal asymmetry. The data were recorded with the ATLAS detector at the LHC in the year 2011 and correspond to an integrated luminosity of 158 $\mathrm{pb}^{-1}$. The selection criteria demand the average transverse momentum of the two leading jets in an event to be larger than 250 GeV. The data at detector level are well described by Monte Carlo event generators. They are unfolded to the particle level and compared with theoretical calculations at next-to-leading-order accuracy. The agreement between data and theory is good and provides a precision test of perturbative Quantum Chromodynamics at large momentum transfers. From this comparison, the strong coupling constant given at the $Z$ boson mass is determined to be $α_{\mathrm{s}}(m_Z) = 0.1173 \pm 0.0010 \mbox{ (exp.) }^{+0.0065}_{-0.0026} \mbox{ (theo.)}$.
description: 19 pages plus author list (35 pages total), 4 figures, 4 tables, submitted to Phys. Lett. B, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2014-03/
(401537) Kenneth Robertson Baxter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development
Creators: name: Dai, Qing
name: He, Chuan
name: Inoue, Azusa
name: Zhang, Yi
name: Shen, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: One of the recent advances in the epigenetic field is the demonstration that the Tet family of proteins are capable of catalyzing conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC). Interestingly, recent studies have shown that 5hmC can be further oxidized by Tet proteins to generate 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), which can be removed by thymine DNA glycosylase (TDG). To determine whether Tet-catalyzed conversion of 5mC to 5fC and 5caC occurs in vivo in zygotes, we generated antibodies specific for 5fC and 5caC. By immunostaining, we demonstrate that loss of 5mC in the paternal pronucleus is concurrent with the appearance of 5fC and 5caC, similar to that of 5hmC. Importantly, instead of being quickly removed through an enzyme-catalyzed process, both 5fC and 5caC exhibit replication-dependent dilution during mouse preimplantation development. These results not only demonstrate the conversion of 5mC to 5fC and 5caC in zygotes, but also indicate that both 5fC and 5caC are relatively stable and may be functional during preimplantation development. Together with previous studies, our study suggests that Tet-catalyzed conversion of 5mC to 5hmC/5fC/5caC followed by replication-dependent dilution accounts for paternal DNA demethylation during preimplantation development.
Sensitive survey for 13CO, CN, H2CO, and SO in the disks of T Tauri and Herbig Ae stars II: Stars in $ρ$ Oph and upper Scorpius
Creators: name: Reboussin, L.
name: Guilloteau, S.
name: Simon, M.
name: Grosso, N.
name: Wakelam, V.
name: Di Folco, E.
name: Dutrey, A.
name: Piétu, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We attempt to determine the molecular composition of disks around young low-mass stars in the $ρ$ Oph region and to compare our results with a similar study performed in the Taurus-Auriga region. We used the IRAM 30 m telescope to perform a sensitive search for CN N=2-1 in 29 T Tauri stars located in the $ρ$ Oph and upper Scorpius regions. $^{13}$CO J=2-1 is observed simultaneously to provide an indication of the level of confusion with the surrounding molecular cloud. The bandpass also contains two transitions of ortho-H$_2$CO, one of SO, and the C$^{17}$O J=2-1 line, which provides complementary information on the nature of the emission. Contamination by molecular cloud in $^{13}$CO and even C$^{17}$O is ubiquitous. The CN detection rate appears to be lower than for the Taurus region, with only four sources being detected (three are attributable to disks). H$_2$CO emission is found more frequently, but appears in general to be due to the surrounding cloud. The weaker emission than in Taurus may suggest that the average disk size in the $ρ$ Oph region is smaller than in the Taurus cloud. Chemical modeling shows that the somewhat higher expected disk temperatures in $ρ$ Oph play a direct role in decreasing the CN abundance. Warmer dust temperatures contribute to convert CN into less volatile forms. In such a young region, CN is no longer a simple, sensitive tracer of disks, and observations with other tracers and at high enough resolution with ALMA are required to probe the gas disk population.
description: 18 pages, 5 figures, accepted for publication in A&A
Data-Flow Analysis Heuristic for Vulnerability Detection on Configurable Systems
Creators: name: Gleyberson Andrade
name: Elder Cirilo
name: Durelli, Vinicius
name: Cafeo, Bruno
name: Adachi, Eiji
Publisher: name: Zenodo
Year: 2020

description: Configurable software systems offer a variety of benefits such as supporting easy configuration of custom behaviors for distinctive needs. However, it is known that the presence of configuration options in source code complicates maintenance tasks and requires additional effort from developers when adding or editing code statements. They need to consider multiple configurations when executing tests or performing static analysis to detect vulnerabilities. Therefore, vulnerabilities have been widely reported in configurable software systems. Unfortunately, the effectiveness of vulnerability detection depends on how the multiple configurations (i.e., samples sets) are selected. In this paper, we tackle the challenge of generating more adequate system configuration samples by taking into account the intrinsic characteristics of security vulnerabilities. We propose a new sampling heuristic based on data-flow analysis for recommending the subset of configurations that should be analyzed individually. Our results show that we can achieve high vulnerability-detection effectiveness with a small sample size.
FluidNET abstract - Characterization of Aqueous Silica Species and In-situ Dissolution-Precipitation Monitoring Using Raman and FTIR Spectroscopy
Creators: name: Cedillo, Andrea Billarent
name: Goudswaard, Cédric
name: King, Helen
name: Plümper, Oliver
Publisher: name: Zenodo
Year: 2022

description: Characterization of aqueous silica species and in-situ dissolution-precipitation monitoring using Raman and FTIR spectroscopy. In the permeable upper crust, dissolution and precipitation reactions between silicate minerals and the silica species in aqueous fluids affect the porosity and permeability of the rocks, sealing existing fluid pathways or producing new ones. Understanding the evolution of these pathways is highly significant in the improvement of resource exploitation and the sequestration of contaminants and greenhouse gases. Silica reactivity is important in diverse geological, biogeochemical, and material science studies. Yet, there is no experimental research on the spatial and temporal tracing of dissolution-precipitation reactions in silica-rich fluid systems. Previous studies have used 18O-doped water to identify the chemical reaction mechanisms and trace the transportation of material during these reactions. This method has been effectively used in the oxyanion systems PO43- and CO32- using vibrational spectroscopy 1. Silica in aqueous fluids is more complex than the PO43- and CO32- oxyanions, as it can be present in multiple forms such as silicic acid, monomers, and polymers and may form particles such as colloids and even gels whose structure evolves with time. The stability and presence of different silica species and phases can be sensitive to the physicochemical conditions of the fluid. Therefore, in this work, we have built a comprehensive overview of silica behavior related to temperature (22-100 °C), pH (7-13), and ionic strength (varying Na-, K-, Ca-, and Mg chloride salts) that would be applicable to geothermal systems. Silica in these systems was analyzed in-situ with Raman and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Using vibrational spectroscopy also enabled us to observe changes in the water structure under different conditions, which may affect the exchange rate of 18O from doped water into silica. This information was then combined to test if 18O-exchange from doped water coupled with vibrational spectroscopy can be used as a reaction tracer for the silica system. King & Geisler Minerals 8, 1–15 (2018).
(401539) Grace Margaret Gay Baxter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Radiological features of caseous calcification of mitral annulus
Creators: name: Ishchenko, Michael
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Thorax
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Calcifications / Calculi
subject: Image verification
subject: Metabolic disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Caseous calcification of mitral annulus is a rare variant of calcification of the mitral valve annulus. The aim of the study was to describe the typical radiological features in patients with caseous calcification of mitral annulus...
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
Creators: name: Jiang, Wei
name: Wang, Jinzhao
name: Zhang, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Definitive endoderm differentiation is crucial for generating respiratory and gastrointestinal organs including pancreas and liver. However, whether epigenetic regulation contributes to this process is unknown. Here, we show that the H3K27me3 demethylases KDM6A and KDM6B play an important role in endoderm differentiation from human ESCs. Knockdown of KDM6A or KDM6B impairs endoderm differentiation, which can be rescued by sequential treatment with WNT agonist and antagonist. KDM6A and KDM6B contribute to the activation of WNT3 and DKK1 at different differentiation stages when WNT3 and DKK1 are required for mesendoderm and definitive endoderm differentiation, respectively. Our study not only uncovers an important role of the H3K27me3 demethylases in definitive endoderm differentiation, but also reveals that they achieve this through modulating the WNT signaling pathway.
Analyzing Continuous Integration Bad Practices in Closed-Source Projects: An Initial Study
Creators: name: Silva, Ruben B. T.
name: Bezerra, Carla I. M.
Publisher: name: Zenodo
Year: 2020

description: SBES 2020 NIER - Continuous integration (CI) is a process widely used in projects of different types and sizes, generally aimed at improving development and also ensuring the quality of the software. However, some bad practices can mitigate or invalidate the beneficial effects of CI. In this context, we present an initial study to analyze CI bad practices in two closed-source projects. The study had as main research questions: (i) the frequency of CI bad practices in projects, (ii) the time that builds failures remain unresolved in projects, and (iii) the effects of CI bad practices on software health from the perspective of developers and project managers. For this, we carried out a mapping of the existence of bad practices through a questionnaire directed to the projects team. Also, it was realized the analysis of the pipeline history of the projects. Our findings indicate that the most common CI bad practices are related to improper management of the CI repository, and defective builds usually take a long time to fix. Besides, we found that the difficulties resulting from CI bad practices promote an increase in the development cost and reduction of software quality assurance.
SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
Creators: name: Morozova, Olena
name: Miller, Freda D.
name: Pevny, Larysa
name: Biernaskie, Jeffrey
name: Marra, Marco
name: Paris, Maryline
name: Fagan, B. Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Despite the remarkable regenerative capacity of mammalian skin, an adult dermal stem cell has not yet been identified. Here, we investigated whether skin-derived precursors (SKPs) might fulfill such a role. We show that SKPs derive from Sox2+ hair follicle dermal cells, and that these two cell populations are similar with regard to their transcriptome and functional properties. Both clonal SKPs and endogenous Sox2+ cells induce hair morphogenesis, differentiate into dermal cell types, and home to a hair follicle niche upon transplantation. Moreover, hair follicle-derived SKPs self-renew, maintain their multipotency, and serially reconstitute hair follicles. Finally, grafting experiments show that follicle-associated dermal cells move out of their niche to contribute cells for dermal maintenance and wound-healing. Thus, SKPs derive from Sox2+ follicle-associated dermal precursors and display functional properties predicted of a dermal stem cell, contributing to dermal maintenance, wound-healing, and hair follicle morphogenesis.
Analyzing Continuous Integration Bad Practices in Closed-Source Projects: An Initial Study
Creators: name: Silva, Ruben B. T.
name: Bezerra, Carla I. M.
Publisher: name: Zenodo
Year: 2020

description: SBES RESEARCH TRACK - Continuous integration (CI) is a process widely used in projects of different types and sizes, generally aimed at improving development and also ensuring the quality of the software. However, some bad practices can mitigate or invalidate the beneficial effects of CI. In this context, we present an initial study to analyze CI bad practices in two closed-source projects. The study had as main research questions: (i) the frequency of CI bad practices in projects, (ii) the time that builds failures remain unresolved in projects, and (iii) the effects of CI bad practices on software health from the perspective of developers and project managers. For this, we carried out a mapping of the existence of bad practices through a questionnaire directed to the projects team. Also, it was realized the analysis of the pipeline history of the projects. Our findings indicate that the most common CI bad practices are related to improper management of the CI repository, and defective builds usually take a long time to fix. Besides, we found that the difficulties resulting from CI bad practices promote an increase in the development cost and reduction of software quality assurance.
Quasicontinuous and separately continuous functions with values in Maslyuchenko spaces
Creators: name: Banakh, Taras
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54C08, 54E18, 54E20, 54E35, 54E52

description: We generalize some classical results about quasicontinuous and separately continuous functions with values in metrizable spaces to functions with values in certain generalized metric spaces, called Maslyuchenko spaces. We establish stability properties of the classes of Maslyuchenko spaces and study the relation of these classes to known classes of generalized metric spaces (such as Piotrowski or Stegall spaces). One of our results says that for any $\aleph_0$-space $Z$ and any separately continuous function $f:X\times Y\to Z$ defined on the product of a topological space $X$ and a second-countable space $Y$, the set $D(f)$ of discontinuity points of $f$ has meager projection on $X$.
description: 15 pages
MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
Creators: name: Gomez, Shawn M.
name: Li, Leping
name: Mieczkowski, Piotr A.
name: Huang, Weichun
name: Prat, Aleix
name: Midland, Alicia A.
name: Johnson, Gary L.
name: Johnson, Nancy L.
name: Abell, Amy N.
name: Jordan, Nicole Vincent
name: Granger, Deborah A.
name: Perou, Charles M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone acetyltransferase CBP, and that acetylation of histones H2A and H2B by CBP is required to maintain the epithelial phenotype. Combined loss of MAP3K4/CBP activity represses expression of epithelial genes and causes TS cells to undergo EMT while maintaining their self-renewal and multipotency properties. The expression profile of MAP3K4 deficient TS cells defines an H2B acetylation regulated gene signature that closely overlaps with that of human breast cancer cells. Taken together, our data define an epigenetic switch that maintains the epithelial phenotype in TS cells and reveal previously unrecognized genes potentially contributing to breast cancer.
Elektronische Ressourcen im Geschäftsgang
Creators: name: Rüter, Christian
Publisher: name: Humboldt-Universität zu Berlin, Philosophische Fakultät I, Institut für Bibliotheks- und Informationswissenschaft
Year: 2010
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Online-Ressourcen erfordern aufgrund ihrer im Gegensatz zu traditionellen Medien andersartigen Beschaffenheit, Erwerbung und Nutzungsszenarien neue und anders fokussierte Geschäftsgänge in Bibliotheken. Einzelerwerbungen und -katalogisierungen treten in den Hintergrund zugunsten von Paketkäufen, Datenmigrationsszenarien und Updateverfahren. Diese Anforderungen müssen in die nach wie vor vorhandenen alten Abläufe integriert werden bzw. diese ergänzen und/oder neu konstituieren. Am konkreten Beispiel der Universitätsbibliothek der Humboldt-Universität zu Berlin werden die analysierten Gegebenheiten in neu entworfene Geschäftsgänge integriert. Wichtig ist dabei, die Bearbeitung von Online-Ressourcen nicht zu einem „Expertenthema“ innerhalb der Bibliothek werden zu lassen und gleichzeitig doch Spezialisierungen möglich zu machen, die der Aufgabe gerecht werden. Darüber hinaus sind erste Überlegungen zu einer realen Umsetzung der Geschäftsgänge die Voraussetzung für deren erfolgreiche Einführung.
(401535) David Baxter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
INO80 Facilitates Pluripotency Gene Activation in Embryonic Stem Cell Self-Renewal, Reprogramming, and Blastocyst Development
Creators: name: Du, Ying
name: Lackford, Brad
name: Fargo, David C.
name: Jothi, Raja
name: Zheng, Xiaofeng
name: Ward, James M.
name: Williams, Carmen J.
name: Han, Leng
name: Miao, Yi Liang
name: Shimbo, Takashi
name: Wang, Li
name: Zhou, Bingying
name: Wade, Paul A.
name: Hu, Guang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The master transcription factors play integral roles in the pluripotency transcription circuitry of embryonic stem cells (ESCs). How they selectively activate expression of the pluripotency network while simultaneously repressing genes involved in differentiation is not fully understood. Here we define a requirement for the INO80 complex, a SWI/SNF family chromatin remodeler, in ESC self-renewal, somatic cell reprogramming, and blastocyst development. We show that Ino80, the chromatin remodeling ATPase, co-occupies pluripotency gene promoters with the master transcription factors, and its occupancy is dependent on Oct4 and Wdr5. At the pluripotency genes, Ino80 maintains open chromatin architecture and licenses recruitment of Mediator and RNA Polymerase II for gene activation. Our data reveal an essential role for INO80 in the expression of the pluripotency network, and illustrate the coordination among chromatin remodeler, transcription factor, and histone modifying enzyme in the regulation of the pluripotent state.