cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A multicenter, randomized, open-label, 2-arm parallel study to compare the pharmacokinetics, safety and tolerability of AVT02 administered subcutaneously via prefilled syringe or autoinjector in healthy adults
Creators: name: Wynne, Christopher
name: Schwabe, Christian
name: Stroissnig, Heimo
name: Dias, Roshan
name: Sobierska, Joanna
name: Guenzi, Eric
name: Otto, Hendrik
name: Sattar, Abid
name: Haliduola, Halimu N
name: Edwald, Elin
name: Berti, Fausto
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Virology

description: AVT02 is an adalimumab biosimilar, with bioequivalence previously established along with clinical similarity. This study assessed the pharmacokinetic (PK) similarity of a single dose of 100 mg/mL AVT02 administered via prefilled syringe (PFS) or autoinjector (AI). In this open-label, 2-arm, parallel-group study, healthy adults were randomized 1:1 to receive one 40 mg (100 mg/mL) dose of AVT02 subcutaneously via PFS (N = 102) or AI (N = 105). Primary PK parameters (Cmax, AUC0-t and AUC0-inf) were evaluated up to Day 64 of the study. Secondary PK parameters, safety, tolerability and immunogenicity were also assessed. The 90% CIs for the ratio of geometric least squares means were contained within the pre-specified 80–125% equivalence margins for the primary PK parameters, demonstrating bioequivalence of AVT02 when administered by PFS or AI. The incidence of treatment-emergent adverse events was comparable between the two groups, with a low frequency of injection site reactions observed. Immunogenicity profiles were also similar between the two groups. Bioequivalence was demonstrated for a single dose of AVT02 administered via PFS or AI. These results will help to increase availability of devices for patients, enabling treatment choice and flexibility.
Real-world observational cohort study of treatment patterns and safety outcomes of infliximab biosimilar CT-P13 for the treatment of inflammatory bowel disease (CONNECT-IBD)
Creators: name: Bokemeyer, Bernd
name: Hlavaty, Tibor
name: Allez, Matthieu
name: Selema, Pamela
name: Moosavi, Shahrzad
name: Cadatal, Mary Jane
name: Fowler, Heather
name: Mueller, Markus
name: Liau, Katherine F
name: Gisbert, Javier P
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: The objective of this non-interventional, observational prospective cohort study (CONNECT-IBD) was to assess the use of CT-P13 (Inflectra®) in the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC) in the context of treatment with reference infliximab (IFX; Remicade®). Patients (recruited April 2015 to October 2018) at 150 sites across 13 European countries were followed for up to 2 years. Primary outcomes were safety, population characteristics, and drug utilization patterns. Secondary outcomes included clinical assessment of disease activity. Data were analyzed descriptively. Overall, 2543 patients (CD, n = 1676; UC, n = 867) were included. In the CT-P13 cohort (n = 1522), median disease duration was 63 (0–579) months and 30% of patients were IFX naïve; median duration of prior IFX treatment was 5 months. During the observation period, median duration of drug exposure was 14 (0–28) months. 41% of patients reported 912 all-causality treatment-emergent adverse events (TEAEs); 24% experienced treatment-related TEAEs. Most TEAEs were of mild-to-moderate severity. Treatment-emergent serious adverse events were reported by 17% of patients. Safety information for CT-P13 in this large study was consistent with the known safety profile for IFX and did not alter the established benefit-risk profile of CT-P13.
Randomized, double-blind, multicenter study to evaluate efficacy, safety, tolerability, and immunogenicity between AVT04 and the reference product ustekinumab in patients with moderate-to-severe chronic plaque psoriasis
Creators: name: Feldman, Steven R
name: Reznichenko, Nataliya
name: Berti, Fausto
name: Duijzings, Paul
name: Ruffieux, Ruth
name: Otto, Hendrik
name: Haliduola, Halimu N
name: Leutz, Steffen
name: Stroissnig, Heimo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study compared efficacy, safety, tolerability, pharmacokinetics (PK), and immunogenicity between AVT04 and reference product (RP) ustekinumab (Stelara®) in patients with moderate-to-severe chronic plaque psoriasis (PsO). This multicenter, double-blind, 52-week study randomized patients in 1:2 ratio to AVT04 or RP. At week 16, responsive patients (≥50% improvement in psoriasis area and severity index (PASI)) previously on AVT04 continued on AVT04, while those on RP were re-randomized 1:1 to switch to AVT04 or stay on RP. The primary endpoint was a percent improvement in PASI from baseline to week 12. Therapeutic equivalence was demonstrated if the confidence interval (CI) for the adjusted difference in means was contained within the equivalence margins; ±10% (90%CI). Of the 581 patients initially randomized (AVT04:RP, 194:387), 575 completed week 16 and 544 completed end of study visit. The percent PASI improvement for AVT04 vs RP was 87.3% vs 86.8% (CI: −2.14%, 3.01%); study met its primary endpoint. Efficacy, safety and PK profiles were comparable across treatment arms throughout the entire study duration, and the incidence of antibodies to ustekinumab had no clinically meaningful impact. This study demonstrates the therapeutic equivalence between AVT04 and RP in patients with moderate-to-severe chronic PsO, with similar safety and tolerability. NCT04930042; EudraCT Number: 2020-004,493-22
An innovative concept for the AsteroidFinder/SSB focal plane assembly
Creators: name: Schindler, Karsten
name: Tschentscher, Matthias
name: Koncz, Alexander
name: Solbrig, Michael
name: Michaelis, Harald
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: This paper gives a summary on the system concept and design of the focal plane assembly of AsteroidFinder/SSB, a small satellite mission which is currently under development at the German Aerospace Center (DLR). An athermal design concept has been developed in accordance to the requirements of the instrument and spacecraft. Key aspects leading to this approach have been a trade-off study of the mechanical telescope interface, the definition of electrical and thermal interfaces and a material selection which minimizes thermally induced stresses. As a novelty, the structure will be manufactured from a machinable AlN-BN composite ceramic. To enable rapid design iterations and development, an integrated modeling approach has been used to conduct a thermo-mechanical analysis of the proposed concept in order to prove its feasibility. The steady-state temperature distribution for various load cases and the resulting stress and strain within the assembly have both been computed using a finite element simulation.
description: 12 pages, 7 figures
Scheme-Independent Calculation of $γ_{\barψψ,IR}$ for an SU(3) Gauge Theory
Creators: name: Ryttov, Thomas A.
name: Shrock, Robert
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a scheme-independent calculation of the infrared value of the anomalous dimension of the fermion bilinear, $γ_{\barψψ,IR}$ in an SU(3) gauge theory as a function of the number of fermions, $N_f$, via a series expansion in powers of $Δ_f$, where $Δ_f=(16.5-N_f)$, to order $Δ_f^4$. We perform an extrapolation to obtain the first determination of the exact $γ_{\barψψ,IR}$ from continuum field theory. The results are compared with calculations of the $n$-loop values of this anomalous dimension from series in powers of the coupling and from lattice measurements.
description: 5 page latex, 1 figure
Locking of length scales in two-band superconductors
Creators: name: Ichioka, M.
name: Kogan, V. G.
name: Schmalian, J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A model of a clean two-band s-wave superconductor with cylindrical Fermi surfaces, different Fermi velocities v_{1,2}, and a general 2x2 coupling matrix V_{alpha beta} is used to study the order parameter distribution in vortex lattices. The Eilenberger weak coupling formalism is used to calculate numerically the spatial distributions of the pairing amplitudes Delta_1_ and Delta_2_ of the two bands for vortices parallel to the Fermi cylinders. For generic values of the interband coupling V_{12}, it is shown that, independently of the couplings V_{alpha beta}, of the ratio v_1 /v_2, of the temperature, and the applied field, the length scales of spatial variation of Delta_1 and of Delta_2 are the same within the accuracy of our calculations. The only exception from this single length-scale behavior is found for V_{12} --> 0, i.e., for nearly decoupled bands.
description: 7 pages, 8 figures
Koornwinder polynomials and the stationary multi-species asymmetric exclusion process with open boundaries
Creators: name: Cantini, Luigi
name: Garbali, Alexandr
name: de Gier, Jan
name: Wheeler, Michael
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We prove that the normalisation of the stationary state of the multi-species asymmetric simple exclusion process (mASEP) is a specialisation of a Koornwinder polynomial. As a corollary we obtain that the normalisation of mASEP factorises as a product over multiple copies of the two-species ASEP.
description: 25 pages
Lithium depletion is a strong test of core-envelope recoupling
Creators: name: Somers, Garrett
name: Pinsonneault, Marc H.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Rotational mixing is a prime candidate for explaining the gradual depletion of lithium from the photospheres of cool stars during the main sequence. However, previous mixing calculations have relied primarily on treatments of angular momentum transport in stellar interiors incompatible with solar and stellar data, in the sense that they overestimate internal differential rotation. Instead, recent studies suggest that stars are strongly differentially rotating at young ages, but approach solid body rotation during their lifetimes. We modify our rotating stellar evolution code to include an additional source of angular momentum transport, a necessary ingredient for explaining the open cluster rotation pattern, and examine the consequences for mixing. We confirm that core-envelope recoupling with a $\sim$20 Myr timescale is required to explain the evolution of the mean solar-mass rotation pattern along the main sequence, and demonstrate that it also provides a more accurate description of the Li depletion pattern seen in open clusters. Recoupling produces a characteristic pattern of efficient mixing at early ages and little mixing at late ages, thus predicting a flattening of Li depletion at a few Gyr, in agreement with the observed late-time evolution. Using Li abundances, we argue that the timescale for core-envelope recoupling during the main sequence decreases sharply with increasing mass. We discuss implications of this finding for stellar physics, including the viability of gravity waves and magnetic fields as agents of angular momentum transport. We also raise the possibility of intrinsic differences in initial conditions in star clusters, using M67 as an example.
description: 15 pages, 11 figures. Accepted to ApJ
Standardization and harmonization of RE and SEE criteria
Creators: name: Fernández, Elena
name: Vermeersch, Elise
name: Scholz, Johannes
name: Wagner, Michelle
name: Cunha, Sónia
name: Wewer, Valentin
name: Rötter, Vera Susanne
Publisher: name: Zenodo
Year: 2024

description: This report outlines the CE-RISE project's efforts to map, analyze, and harmonize various methodologies for assessing product circularity and sustainability, in response to European legislation like the European Green Deal and Circular Economy Action Plan. Task 1.2 focused on identifying relevant standards, certifications, and labels, and creating standardized factsheets for 375 documents. The report highlights the lack of standardized methods in legislation, the potential of existing standards for developing circularity indicators, and the challenges in assessing socio-economic and environmental impacts. The findings emphasize the ongoing need for harmonization to support the circular economy transition.
Setting a disordered password on a photonic memory
Creators: name: Su, Shih-Wei
name: Gou, Shih-Chuan
name: Chew, Lock Yue
name: Chang, Yu-Yen
name: Yu, Ite A.
name: Kalachev, Alexey
name: Liao, Wen-Te
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Encryption is a vital tool of information technology protecting our data in the world with ubiquitous computers. While photons are regarded as ideal information carriers, it is a must to implement such data protection on all-optical storage. However, the intrinsic risk of data breaches in existing schemes of photonic memory was never addressed. We theoretically demonstrate the first protocol using spatially disordered laser fields to encrypt data stored on an optical memory, namely, encrypted photonic memory. Compare with a digital key, a continuous disorder encrypts stored light pulses with a rather long key length against brute-force attacks. To address the broadband storage, we also investigate a novel scheme of disordered echo memory with a high fidelity approaching unity. Our results pave novel ways to encrypt different schemes of photonic memory based on quantum optics and raise the security level of photonic information technology.
description: 5 pages and 4 figures
Geometrically Exact Finite Element Formulations for Curved Slender Beams: Kirchhoff-Love Theory vs. Simo-Reissner Theory
Creators: name: Meier, Christoph
name: Wall, Wolfgang A.
name: Popp, Alexander
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: The present work focuses on geometrically exact finite elements for highly slender beams. It aims at the proposal of novel formulations of Kirchhoff-Love type, a detailed review of existing formulations of Kirchhoff-Love and Simo-Reissner type as well as a careful evaluation and comparison of the proposed and existing formulations. Two different rotation interpolation schemes with strong or weak Kirchhoff constraint enforcement, respectively, as well as two different choices of nodal triad parametrizations in terms of rotation or tangent vectors are proposed. The combination of these schemes leads to four novel finite element variants, all of them based on a C1-continuous Hermite interpolation of the beam centerline. Essential requirements such as representability of general 3D, large-deformation, dynamic problems involving slender beams with arbitrary initial curvatures and anisotropic cross-section shapes or preservation of objectivity and path-independence will be investigated analytically and verified numerically for the different formulations. It will be shown that the geometrically exact Kirchhoff-Love beam elements proposed in this work are the first ones of this type that fulfill all the considered requirements. On the contrary, Simo-Reissner type formulations fulfilling these requirements can be found in the literature very well. However, it will be argued that the shear-free Kirchhoff-Love formulations can provide considerable numerical advantages when applied to highly slender beams. Concretely, several representative numerical test cases confirm that the proposed Kirchhoff-Love formulations exhibit a lower discretization error level as well as a considerably improved nonlinear solver performance in the range of high beam slenderness ratios as compared to two representative Simo-Reissner element formulations from the literature.
Observation of the anisotropic Dirac cone in the band dispersion of 112-structured iron-based superconductor Ca0.9La0.1FeAs2
Creators: name: Liu, Z. T.
name: Xing, X. Z.
name: Li, M. Y.
name: Zhou, W.
name: Sun, Y.
name: Fan, C. C.
name: Yang, H. F.
name: Liu, J. S.
name: Yao, Q.
name: Li, W.
name: Shi, Z. X.
name: Shen, D. W.
name: Wang, Z.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: CaFeAs2 is a parent compound of recently discovered 112-type iron-based superconductors. It is predicted to be a staggered intercalation compound that naturally integrates both quantum spin Hall insulating and superconducting layers and an ideal system for the realization of Majorana modes. We performed a systematical angle-resolved photoemission spectroscopy and first-principle calculation study of the slightly electron-doped CaFeAs2. We found that the zigzag As chain of 112-type iron-based superconductors play a considerable role in the low-energy electronic structure, resulting in the characteristic Dirac-cone like band dispersion as the prediction. Our experimental results further confirm that these Dirac cones only exists around the X but not Y points in the Brillouin zone, breaking the S4 symmetry at iron sites. Our findings present the compelling support to the theoretical prediction that the 112-type iron-based superconductors might host the topological nontrivial edge states. The slightly electron doped CaFeAs2 would provide us a unique opportunity to realize and explore Majorana fermion physics.
description: 5 pages, 4 figures
Measuring Turbulence in TW Hya with ALMA: Methods and Limitations
Creators: name: Teague, Richard
name: Guilloteau, Stephane
name: Semenov, Dmitry
name: Henning, Thomas
name: Dutrey, Anne
name: Pietu, Vincent
name: Birnstiel, Tilman
name: Chapillon, Edwige
name: Hollenbach, David
name: Gorti, Uma
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We obtain high spatial and spectral resolution images of the CO J=2-1, CN N=2-1 and CS J=5-4 emission with ALMA in Cycle~2. The radial distribution of the turbulent broadening is derived with three approaches: two `direct' and one modelling. The first requires a single transition and derives \Tex{} directly from the line profile, yielding a \vturb{}. The second assumes two different molecules are co-spatial thus their relative linewidths allow for a calculation of \Tkin{} and \vturb{}. Finally we fit a parametric disk model where physical properties of the disk are described by power laws, to compare our `direct' methods with previous values. The two direct methods were limited to the outer $r > 40$~au disk due to beam smear. The direct method found \vturb{} ranging from $\approx$~\vel{130} at 40~au, dropping to $\approx$~\vel{50} in the outer disk, qualitatively recovered with the parametric model fitting. This corresponds to roughly $0.2 - 0.4~c_s$. CN was found to exhibit strong non-LTE effects outside $r \approx 140$~au, so \vturb{} was limited to within this radius. The assumption that CN and CS are co-spatial is consistent with observed linewidths only within $r \lesssim 100$~au, within which \vturb{} was found to drop from \vel{100} ($\approx~0.4~c_s$) to nothing at 100~au. The parametric model yielded a near constant \vel{50} for CS ($0.2 - 0.4~c_s$). We demonstrate that absolute flux calibration is and will be the limiting factor in all studies of turbulence using a single molecule. The magnitude of the dispersion is comparable with or below that predicted by the magneto-rotational instability theory. A more precise comparison would require to reach an absolute calibration precision of order 3\%, or to find a suitable combination of light and heavy molecules which are co-located in the disk.
description: Accepted by A&A, 30/5/16
The long-term dynamical evolution of disc-fragmented multiple systems in the Solar Neighborhood
Creators: name: Li, Yun
name: Kouwenhoven, M. B. N.
name: Stamatellos, D.
name: Goodwin, S. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The origin of very low-mass hydrogen-burning stars, brown dwarfs, and planetary-mass objects at the low-mass end of the initial mass function is not yet fully understood. Gravitational fragmentation of circumstellar discs provides a possible mechanism for the formation of such low-mass objects. The kinematic and binary properties of very low-mass objects formed through disc fragmentation at early times (< 10 Myr) were discussed in Li et al. (2015). In this paper we extend the analysis by following the long-term evolution of disc-fragmented systems, up to an age of 10 Gyr, covering the ages of the stellar and substellar population in the Galactic field. We find that the systems continue to decay, although the rates at which companions escape or collide with each other are substantially lower than during the first 10 Myr, and that dynamical evolution is limited beyond 1 Gyr. By t = 10 Gyr, about one third of the host stars is single, and more than half have only one companion left. Most of the other systems have two companions left that orbit their host star in widely separated orbits. A small fraction of companions have formed binaries that orbit the host star in a hierarchical triple configuration. The majority of such double companion systems have internal orbits that are retrograde with respect to their orbits around their host stars. Our simulations allow a comparison between the predicted outcomes of disc-fragmentation with the observed low-mass hydrogen-burning stars, brown dwarfs, and planetary-mass objects in the Solar neighborhood. Imaging and radial velocity surveys for faint binary companions among nearby stars are necessary for verification or rejection for the formation mechanism proposed in this paper.
Radiative feedback and cosmic molecular gas: the role of different radiative sources
Creators: name: Maio, U.
name: Petkova, M.
name: De Lucia, G.
name: Borgani, S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present results from multifrequency radiative hydrodynamical chemistry simulations addressing primordial star formation and related stellar feedback from various populations of stars, stellar energy distributions (SEDs) and initial mass functions. Spectra for massive stars, intermediate-mass stars and regular solar-like stars are adopted over a grid of 150 frequency bins and consistently coupled with hydrodynamics, heavy-element pollution and non-equilibrium species calculations. Powerful massive population III stars are found to be able to largely ionize H and, subsequently, He and He$^+$, causing an inversion of the equation of state and a boost of the Jeans masses in the early intergalactic medium. Radiative effects on star formation rates are between a factor of a few and 1 dex, depending on the SED. Radiative processes are responsible for gas heating and photoevaporation, although emission from soft SEDs has minor impacts. These findings have implications for cosmic gas preheating, primordial direct-collapse black holes, the build-up of "cosmic fossils" such as low-mass dwarf galaxies, the role of AGNi during reionization, the early formation of extended disks and angular-momentum catastrophe.
description: 19 pages on MNRAS
A multicenter, randomized, open-label, 2-arm parallel study to compare the pharmacokinetics, safety and tolerability of AVT02 administered subcutaneously via prefilled syringe or autoinjector in healthy adults
Creators: name: Wynne, Christopher
name: Schwabe, Christian
name: Stroissnig, Heimo
name: Dias, Roshan
name: Sobierska, Joanna
name: Guenzi, Eric
name: Otto, Hendrik
name: Sattar, Abid
name: Haliduola, Halimu N
name: Edwald, Elin
name: Berti, Fausto
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Virology

description: AVT02 is an adalimumab biosimilar, with bioequivalence previously established along with clinical similarity. This study assessed the pharmacokinetic (PK) similarity of a single dose of 100 mg/mL AVT02 administered via prefilled syringe (PFS) or autoinjector (AI). In this open-label, 2-arm, parallel-group study, healthy adults were randomized 1:1 to receive one 40 mg (100 mg/mL) dose of AVT02 subcutaneously via PFS (N = 102) or AI (N = 105). Primary PK parameters (Cmax, AUC0-t and AUC0-inf) were evaluated up to Day 64 of the study. Secondary PK parameters, safety, tolerability and immunogenicity were also assessed. The 90% CIs for the ratio of geometric least squares means were contained within the pre-specified 80–125% equivalence margins for the primary PK parameters, demonstrating bioequivalence of AVT02 when administered by PFS or AI. The incidence of treatment-emergent adverse events was comparable between the two groups, with a low frequency of injection site reactions observed. Immunogenicity profiles were also similar between the two groups. Bioequivalence was demonstrated for a single dose of AVT02 administered via PFS or AI. These results will help to increase availability of devices for patients, enabling treatment choice and flexibility. NCT03983876
Perturbative approach to covariance matrix of the matter power spectrum
Creators: name: Mohammed, Irshad
name: Seljak, Uros
name: Vlah, Zvonimir
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We evaluate the covariance matrix of the matter power spectrum using perturbation theory up to dominant terms at 1-loop order and compare it to numerical simulations. We decompose the covariance matrix into the disconnected (Gaussian) part, trispectrum from the modes outside the survey (beat coupling or super-sample variance), and trispectrum from the modes inside the survey, and show how the different components contribute to the overall covariance matrix. We find the agreement with the simulations is at a 10\% level up to $k \sim 1 h {\rm Mpc^{-1}}$. We show that all the connected components are dominated by the large-scale modes ($k<0.1 h {\rm Mpc^{-1}}$), regardless of the value of the wavevectors $k,\, k'$ of the covariance matrix, suggesting that one must be careful in applying the jackknife or bootstrap methods to the covariance matrix. We perform an eigenmode decomposition of the connected part of the covariance matrix, showing that at higher $k$ it is dominated by a single eigenmode. The full covariance matrix can be approximated as the disconnected part only, with the connected part being treated as an external nuisance parameter with a known scale dependence, and a known prior on its variance for a given survey volume. Finally, we provide a prescription for how to evaluate the covariance matrix from small box simulations without the need to simulate large volumes.
description: 22 pages, 17 figures, 1 table
An imaging study of a complex solar coronal radio eruption
Creators: name: Feng, S. W.
name: Chen, Y.
name: Song, H. Q.
name: Wang, B.
name: Kong, X. L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Solar coronal radio bursts are enhanced radio emission excited by energetic electrons accelerated during solar eruptions, studies on which are important for investigating the origin and physical mechanism of energetic particles and further diagnosing coronal parameters. Earlier studies suffered from a lack of simultaneous high-quality imaging data of the radio burst and the eruptive structure in the inner corona. Here we present a study on a complex solar radio eruption consisting of a type II and three reversely-drifting type III bursts, using simultaneous EUV and radio imaging data. It is found that the type II burst is closely associated with a propagating and evolving CME-driven EUV shock structure, originated initially at the northern shock flank and later transferred to the top part of the shock. This source transfer is co-incident with the presence of shock decay and enhancing signatures observed at the corresponding side of the EUV front. The electron energy accelerated by the shock at the flank is estimated to be $\sim$ 0.3 c by examining the imaging data of the fast-drifting herringbone structure of the type II burst. The reversely-drifting type III sources are found to be within the ejecta and correlated with a likely reconnection event therein. Implications on further observational studies and relevant space-weather forecasting techniques are discussed.
description: 16 pages,5 figures
Randomized, double-blind, multicenter study to evaluate efficacy, safety, tolerability, and immunogenicity between AVT04 and the reference product ustekinumab in patients with moderate-to-severe chronic plaque psoriasis
Creators: name: Feldman, Steven R
name: Reznichenko, Nataliya
name: Berti, Fausto
name: Duijzings, Paul
name: Ruffieux, Ruth
name: Otto, Hendrik
name: Haliduola, Halimu N
name: Leutz, Steffen
name: Stroissnig, Heimo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: This studycompared efficacy, safety, tolerability, pharmacokinetics (PK), andimmunogenicity between AVT04 and reference product (RP) ustekinumab (Stelara®)in patients with moderate-to-severe chronic plaque psoriasis (PsO). Thismulticenter, double blind, 52-week study randomized patients in 1:2 ratio toAVT04 or RP. At week 16, responsive patients (≥50% improvement in psoriasis area and severity index (PASI)) previously on AVT04 continued on AVT04,while those on RP were re-randomized 1:1 to switch to AVT04 or stay on RP. Theprimary endpoint was percent improvement in PASI from baseline to week 12.Therapeutic equivalence was demonstrated if confidence interval (CI) for theadjusted difference in means contained within the equivalence margins; ±10% (90%CI). Of 581 patientsinitially randomized (AVT04:RP, 194:387), 575 completed week 16 and 544completed end of study visit. The percent PASI improvement for AVT04 vs RP was87.3% vs 86.8% (CI: -2.14%, 3.01%); study met its primary endpoint. Efficacy, safetyand PK profiles were comparable across treatment arms throughout the entirestudy duration, and the incidence of antibodies to ustekinumab had noclinically meaningful impact. The study demonstratestherapeutic equivalence between AVT04 and RP in patients withmoderate-to-severe chronic PsO, with similar safety and tolerability. NCT04930042; EudraCT Number: 2020 -004,493-22
Morbidity and long-term outcome of surgery for renal hyperparathyroidism: results from a prospective cohort
Creators: name: Van Den Heede, K.
name: Claerhout, T.
name: Jansen, S.
name: Blontrock, S.
name: Brusselaers, N.
name: Van Slycke, S.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Virology

description: Surgery remains an important treatment option for renal hyperparathyroidism (rHPT). The number of long-term outcome studies of parathyroidectomy is limited. All consecutive patients with a parathyroidectomy for rHPT between 09/2009 and 04/2021 in a Belgian tertiary referral hospital were prospectively enrolled. The main outcomes were (long-term) cured proportion and postoperative morbidity (hypocalcemia, recurrent laryngeal nerve (RLN) palsy, re-intervention for bleeding, and wound morbidity). Sixty patients with a median age of 57 years were analyzed, including 23 patients before kidney transplantation, 23 patients without kidney transplantation, and 14 patients after kidney transplantation. Median time to transplant was 15 (6–24) months after parathyroidectomy. Morbidity was low with only two non-urgent returns to theatre (wound infection and non-compressive hematoma), two temporary RLN paralyses, and no 30-day mortality. Length of hospital stay was longer in patients with parathyroidectomy before kidney transplant, due to a more severe and prolonged need for calcium supplementation. After a median follow-up of 63 months, 37 patients (62%) were still alive, and 11 patients (18%) developed a recurrence. This single-surgeon, single-center cohort with long-term follow-up confirms the safety and excellent ‘cure’ proportions of surgery for rHPT but stretches the importance of long-term follow-up.
Optical-flow-based background-oriented schlieren technique for measuring a laser-induced underwater shock wave
Creators: name: Hayasaka, Keisuke
name: Tagawa, Yoshiyuki
name: Liu, Tianshu
name: Kameda, Masaharu
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The background-oriented schlieren (BOS) technique with the physics-based optical flow method (OF-BOS) is developed for measuring the pressure field of a laser-induced underwater shock wave. Compared to BOS with the conventional cross-correlation method in PIV (called PIV-BOS), by using the OF-BOS, the displacement field generated by the small density gradient in water can be obtained at the spatial resolution of one vector per pixel. The corresponding density and pressure fields can be further extracted. It is particularly demonstrated that the sufficiently high spatial resolution of the extracted displacement vector field is required in the tomographic reconstruction to correctly infer the pressure field of the spherical underwater shock wave. The capability of the OF-BOS is critically evaluated based on synchronized hydrophone measurements. Special emphasis is placed on direct comparison between the OF-BOS with the PIV-BOS.
description: 18 pages, 17 figures
Variable stars in the Andromeda galaxy using the Gaia Data Release 3
Creators: name: Avgousti, Stella
name: Grigoris Maravelias
name: Bonanos, Alceste
Publisher: name: Zenodo
Year: 2023
Subjects: astrophysics
massive stars
Gaia DR3

description: Massive stars, although rare, are of key importance for understanding the evolution of the Universe and are the progenitors of supernovae, gamma-ray bursts and even gravitational-wave events. An important parameter of massive stars is their mass loss rate, which has a significant impact on their evolution. Despite its importance, mass loss from massive stars and especially episodic mass loss, is poorly understood. Spectroscopy is an important tool to derive stellar properties, but is a time-consuming process. Instead, the availability of large datasets from photometric surveys, provide data for thousands of sources. Hence, a machine-learning tool has been developed, within the ASSESS project (http://assess.astro.noa.gr/), to automate the classification process of evolved massive stars. Using the machine-learning classifier, which is based on mid-IR (Spitzer) and optical (Pan-STARRS) photometry, we have obtained spectral classification of about 1.1 million sources in 25 nearby galaxies. Our study focuses on massive stars in the Andromeda galaxy, for which we have predictions for ~800K sources. We used the Gaia Andromeda Photometric Survey (GAPS), which provides a significant coverage of the galaxy and offers spectral types and photometric time series. By performing a cross-match between the sources from GAPS (~1.2M sources) and our Spitzer catalogue (~800K sources) we identified approximately 26K common sources. For those we calculated the median absolute deviation to analyze the variability, to identify new variables and constrain the spectral class predictions. We plan to verify our results about the variable stars using the published data products from Gaia DR3. In total the GAPS will help us validate the performance of our machine-learning classifier and gain a deeper understanding of the nature of these objects when variability is considered. Our findings could also be used to refine the machine-learning model and improve its accuracy in classifying massive stars.
A Tale of Two Tails: Exploring Stellar Populations in the Tidal Tails of NGC 3256
Creators: name: Rodruck, Michael
name: Konstantopoulos, Iraklis
name: Knierman, Karen
name: Fedotov, Konstantin
name: Mullan, Brendan
name: Gallagher, Sarah
name: Durrell, Patrick
name: Ciardullo, Robin
name: Gronwall, Caryl
name: Charlton, Jane
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have developed an observing program using deep, multiband imaging to probe the chaotic regions of tidal tails in search of an underlying stellar population, using NGC 3256's 400 Myr twin tidal tails as a case study. These tails have different colours of $u - g = 1.05 \pm 0.07$ and $r - i = 0.13 \pm 0.07$ for NGC 3256W, and $u - g = 1.26 \pm 0.07$ and $r - i = 0.26 \pm 0.07$ for NGC 3256E, indicating different stellar populations. These colours correspond to simple stellar population ages of $288^{+11}_{-54}$ Myr and $841^{+125}_{-157}$ Myr for NGC 3256W and NGC 3256E, respectively, suggesting NGC 3256W's diffuse light is dominated by stars formed after the interaction, while light in NGC 3256E is primarily from stars that originated in the host galaxy. Using a mixed stellar population model, we break our diffuse light into two populations: one at 10 Gyr, representing stars pulled from the host galaxies, and a younger component, whose age is determined by fitting the model to the data. We find similar ages for the young populations of both tails, ($195^{-13}_{+0}$ and $170^{-70}_{+44}$ Myr for NGC 3256W and NGC 3256E, respectively), but a larger percentage of mass in the 10 Gyr population for NGC 3256E ($98^{+1}_{-3}\%$ vs $90^{+5}_{-6}\%$). Additionally, we detect 31 star cluster candidates in NGC 3256W and 19 in NGC 2356E, with median ages of 141 Myr and 91 Myr, respectively. NGC 3256E contains several young (< 10 Myr), low mass objects with strong nebular emission, indicating a small, recent burst of star formation.
description: Accepted for publication in MNRAS. 16 pages, 19 figures
Morbidity and long-term outcome of surgery for renal hyperparathyroidism: results from a prospective cohort
Creators: name: Van Den Heede, K.
name: Claerhout, T.
name: Jansen, S.
name: Blontrock, S.
name: Brusselaers, N.
name: Van Slycke, S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Virology

description: Surgery remains an important treatment option for renal hyperparathyroidism (rHPT). The number of long-term outcome studies of parathyroidectomy is limited. All consecutive patients with a parathyroidectomy for rHPT between 09/2009 and 04/2021 in a Belgian tertiary referral hospital were prospectively enrolled. The main outcomes were (long-term) cured proportion and postoperative morbidity (hypocalcemia, recurrent laryngeal nerve (RLN) palsy, re-intervention for bleeding, and wound morbidity). Sixty patients with a median age of 57 years were analyzed, including 23 patients before kidney transplantation, 23 patients without kidney transplantation, and 14 patients after kidney transplantation. Median time to transplant was 15 (6–24) months after parathyroidectomy. Morbidity was low with only two non-urgent returns to theatre (wound infection and non-compressive hematoma), two temporary RLN paralyses, and no 30-day mortality. Length of hospital stay was longer in patients with parathyroidectomy before kidney transplant, due to a more severe and prolonged need for calcium supplementation. After a median follow-up of 63 months, 37 patients (62%) were still alive, and 11 patients (18%) developed a recurrence. This single-surgeon, single-center cohort with long-term follow-up confirms the safety and excellent ‘cure’ proportions of surgery for rHPT but stretches the importance of long-term follow-up.
Why do function word frequencies vary across individuals? Evidence in favour of The Statistical Approximation Hypothesis
Creators: name: Nini, Andrea
Publisher: name: Zenodo
Year: 2023

description: A modern unsolved mystery in applied linguistics is that the frequency of function words can be effectively used to identify the author of a text. Computational methods to identify authors were developed by computer scientists or statisticians who chose to focus on function words because of their high frequency and topic obliviousness (Mosteller & Wallace 1963). However, linguistically speaking, it does not make sense to say that authors differ in their function word frequency because of personal preference. Another reason why this explanation does not make sense is that, as corpus linguistic evidence has always suggested (Sinclair 2004), the basic unit of language is not the word but something larger and more similar to a phrase, a claim compatible with cognitive linguistic and cognitive psychology evidence on language processing (Christiansen & Chater 2016; Langacker 1987). In this paper I introduce a formal theory of linguistic individuality based on cognitive linguistic principles that could offer an explanation in the form of the Statistical Approximation Hypothesis. This hypothesis says that the frequency of function words reflects the distribution of function words in our repository of linguistic units, which, according to usage-based frameworks, should be unique because of the idiosyncratic process of entrenchment (Schmid 2015). If this hypothesis is correct, then authorship analysis methods based on this principle should outperform or perform equally as methods based on function word frequencies. Preliminary evidence based on analysis of existing benchmark corpora for authorship analysis indeed shows that this is the case. New methods simply based on the presence or absence of n-grams perform as well as a sophisticated machine learning or deep learning algorithms that consider frequency of function words. This result is interpreted as indirect evidence in favour of the proposed hypothesis. References Christiansen, Morten H. & Nick Chater. 2016. The Now-or-Never bottleneck: A fundamental constraint on language. Behavioral and Brain Sciences. Cambridge University Press 39. e62. https://doi.org/10.1017/S0140525X1500031X. Langacker, Ronald W. 1987. Foundations of cognitive grammar. Stanford, CA: Stanford University Press. Mosteller, Frederick & David L Wallace. 1963. Inference in an Authorship Problem. Journal of the American Statistical Association 58. 275–309. https://doi.org/10.2307/2283270. Schmid, Hans-Jörg. 2015. A blueprint of the Entrenchment-and- Conventionalization Model. Yearbook of the German Cognitive Linguistics Association 3(1). 3–25. https://doi.org/10.1515/gcla-2015-0002. Sinclair, John. 2004. Trust the Text: Language, Corpus and Discourse. London: Routledge.
Kinematic Downsizing at z~2
Creators: name: Simons, Raymond C.
name: Kassin, Susan A.
name: Trump, Jonathan R.
name: Weiner, Benjamin J.
name: Heckman, Timothy M.
name: Barro, Guillermo
name: Koo, David C.
name: Guo, Yicheng
name: Pacifici, Camilla
name: Koekemoer, Anton
name: Stephens, Andrew W.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present results from a survey of the internal kinematics of 49 star-forming galaxies at z$\,\sim\,$2 in the CANDELS fields with the Keck/MOSFIRE spectrograph (SIGMA, Survey in the near-Infrared of Galaxies with Multiple position Angles). Kinematics (rotation velocity $V_{rot}$ and integrated gas velocity dispersion $σ_g$) are measured from nebular emission lines which trace the hot ionized gas surrounding star-forming regions. We find that by z$\,\sim\,$2, massive star-forming galaxies ($\log\,M_*/M_{\odot}\gtrsim10.2$) have assembled primitive disks: their kinematics are dominated by rotation, they are consistent with a marginally stable disk model, and they form a Tully-Fisher relation. These massive galaxies have values of $V_{rot}/σ_g$ which are factors of 2-5 lower than local well-ordered galaxies at similar masses. Such results are consistent with findings by other studies. We find that low mass galaxies ($\log\,M_*/M_{\odot}\lesssim10.2$) at this epoch are still in the early stages of disk assembly: their kinematics are often supported by gas velocity dispersion and they fall from the Tully-Fisher relation to significantly low values of $V_{rot}$. This "kinematic downsizing" implies that the process(es) responsible for disrupting disks at z$\,\sim\,$2 have a stronger effect and/or are more active in low mass systems. In conclusion, we find that the period of rapid stellar mass growth at z$\,\sim\,$2 is coincident with the nascent assembly of low mass disks and the assembly and settling of high mass disks.
description: 21 pages, 9 figures, 2 tables, submitted to ApJ
Gravitational instability of filamentary molecular clouds, including ambipolar diffusion
Creators: name: Hosseinirad, Mohammad
name: Naficy, Kazem
name: Abbassi, Shahram
name: Roshan, Mahmood
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The gravitational instability of a filamentary molecular cloud in non-ideal magnetohydrodynamics is investigated. The filament is assumed to be in hydrostatic equilibrium. We add the effect of ambipolar diffusion to the filament which is threaded by an initial uniform axial magnetic field along its axis. We write down the fluid equations in cylindrical coordinates and perform linear perturbation analysis. We integrate the resultant differential equations and then derive the numerical dispersion relation. We find that, a more efficient ambipolar diffusion leads to an enhancement of the growth of the most unstable mode, and to increase of the fragmentation scale of the filament.
description: Accepted for publication in MNRAS, 10 pages, 7 figures