The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
Creators: name: Hacker, Kathryn E.
name: Leraas, Kristen M.
name: Smith, Angela B.
name: Seiler, Michael
name: Clarke, Amanda
name: Jensen, Mark A.
name: Liu, Yingchun
name: Wang, Qiaoyan
name: Wood, Christopher G.
name: Kwiatkowski, David J.
name: Chao, Hsu
name: Thorne, Leigh
name: Wong, Tina
name: Czerniak, Bogdan A.
name: Tarnuzzer, Roy W.
name: Davidsen, Tanja
name: Hanf, Benjamin
name: Guin, Ranabir
name: Peterson, James
name: Stojanov, Petar
name: Park, Peter J.
name: Laird, Peter W.
name: Bristow, Christopher A.
name: Lichtenberg, Tara M.
name: Murray, Bradley A.
name: Fan, Yu
name: Cho, Juok
name: Doddapaneni, Harsha
name: Zenklusen, Jean Claude
name: Gabriel, Stacey B.
name: Hoyle, Alan P.
name: Getz, Gad
name: Fargo, David
name: Tickoo, Satish K.
name: Zhul, Jingchun
name: Seth, Sahil
name: Morgan, Margaret
name: Seidman, Jonathan
name: Akbani, Rehan
name: Signoretti, Sabina
name: Benz, Christopher C.
name: Waring, Scot
name: Zhang, Hailei
name: Balasundaram, Miruna
name: Dahdouli, Mike
name: Xi, Liu
name: Bootwalla, Moiz S.
name: Zhang, Jiashan
name: Zmuda, Erik
name: Hawes, Alicia
name: Lee, Junehawk
name: Beroukhim, Rameen
name: Hayes, D. Neil
name: Chin, Lynda
name: Hall, Tracy M.
name: Chen, Fengju
name: Sofia, Heidi J.
name: Kalra, Divya
name: Hoadley, Katherine A.
name: Perou, Charles M.
name: Shuch, Brian
name: Drummond, Jennifer
name: Santoso, Netty
name: Hsieh, James J.
name: Chu, Andy
name: Lewis, Lora
name: Yang, Lixing
name: Butterfield, Yaron S.N.
name: Muzny, Donna
name: Wilkerson, Matthew D.
name: Demchok, John A.
name: Spellman, Paul T.
name: Lee, Semin
name: Kucherlapati, Raju
name: Felau, Ina
name: Marra, Marco A.
name: Tan, Donghui
name: Zhang, Jianhua
name: Hutter, Carolyn M.
name: Ma, Yussanne
name: Mungall, Andrew J.
name: Sheth, Margi
name: Wang, Wenyi
name: Huang, Mei
name: Birol, Inanc
name: Mose, Lisle E.
name: English, Adam
name: Gordenin, Dmitry A.
name: Choi, Yoon La
name: Lim, Emilia
name: Ramirez, Nilsa C.
name: Kaipparettu, Benny A.
name: Buda, Elizabeth
name: Lee, Darlene
name: Vocke, Cathy
name: Lai, Phillip H.
name: Gastier-Foster, Julie M.
name: Jones, Steven J.M.
name: Cherniack, Andrew D.
name: Park, Woong Yang
name: Worrell, Robert
name: Simons, Janae V.
name: Guyer, Mark S.
name: Sougnez, Carrie
name: Shaw, Kenna R.Mills
name: Balu, Saianand
name: Wise, Lisa
name: Bhanot, Gyan
name: Klimczak, Leszek J.
name: Meng, Qingchang
name: Kaelin, William G.
name: Wang, Zhining
name: Boice, Lori
name: Schmidt, Laura S.
name: Meng, Shaowu
name: Downs, Brittany
name: Veluvolu, Umadevi
name: Kim, Jaegil
name: Baboud, Julien
name: Wallen, Eric M.
name: Tabak, Barbara
name: Wu, Junyuan
name: Liu, Jia
name: Baylin, Stephen B.
name: Roach, Jeffrey
name: Roberts, Steven A.
name: Weisenberger, Daniel J.
name: Frazer, Scott
name: Tam, Angela
name: Ma, Singer
name: Jefferys, Stuart R.
name: Eley, Greg
name: Henske, Elizabeth P.
name: Weinstein, John N.
name: Lawrence, Michael S.
name: Hakimi, A. Ari
name: Biehl, Michael
name: Morton, Donna
name: Parfenov, Michael
name: Carter, Scott L.
name: Walton, Jessica
name: Li, Haiyan I.
name: Ally, Adrian
name: Van Den Berg, David J.
name: Protopopov, Alexei
name: Reid, Jeffrey G.
name: Wu, Ye
name: Saksena, Gordon
name: Di-Cara, Daniel
name: Tamboli, Pheroze
name: Walker, Kimberly
name: Auman, J. Todd
name: Kim, Sang Cheol
name: Pantazi, Angeliki
name: Schumacher, Steven E.
name: Buhay, Christian
name: Lin, Pei
name: Donehower, Lawrence A.
name: Kovar, Christie
name: Gibbs, Richard A.
name: Luquette, Lovelace J.
name: Stuart, Josh M.
name: Yang, Liming
name: Sipahimalani, Payal
name: Aldape, Kenneth D.
name: Haussler, David
name: Gehlenborg, Nils
name: Mieczkowski, Piotr A.
name: Fahey, Catherine C.
name: Schein, Jacqueline E.
name: Parker, Joel S.
name: Robertson, A. Gordon
name: Kang, Hyojin
name: Meyerson, Matthew
name: Song, Xingzhi
name: Coarfa, Cristian
name: Rathmell, W. Kimryn
name: Hadjipanayis, Angela
name: Voet, Doug
name: Merino, Maria
name: Jones, Corbin D.
name: Chuah, Eric
name: Black, Aaron D.
name: Xu, Andrew W.
name: Davis, Caleb F.
name: Radenbaugh, Amie
name: Brooks, Denise
name: Kakkar, Nipun
name: Noble, Michael S.
name: Choueiri, Toni K.
name: Zou, Lihua
name: Chudamani, Sudha
name: Cheville, John
name: Thompson, R. Houston
name: Thiessen, Nina
name: Hale, Walker
name: Dhalla, Noreen
name: Shen, Hui
name: Zack, Travis I.
name: Heiman, David I.
name: Ahn, Jaeil
name: Wan, Yunhu
name: Wheeler, David A.
name: Triche, Timothy
name: Lee, Eunjung
name: Pihl, Todd
name: Bodenheimer, Tom
name: Wang, Min
name: Ozenberger, Bradley A.
name: Lang, Martin
name: Reuter, Victor
name: Holt, Robert A.
name: Lee, June Koo
name: Ricketts, Christopher J.
name: Mayo, Michael
name: Kasaian, Katayoon
name: Soloway, Mathew G.
name: Bowen, Jay
name: Moore, Richard A.
name: Atkins, Michael B.
name: Gunaratne, Preethi H.
name: Velaga, Sudhakar
name: Linehan, W. Marston
name: Creighton, Chad J.
name: Ayala, Brenda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations.