cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transgenic mice that develop pituitary tumors. A model for Cushing's disease.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Transgenic mice that developed adrenocorticotropic hormone (ACTH)-producing pituitary tumors were generated with the polyoma early region promotor linked to a cDNA encoding polyoma large T antigen (PyLT). Light microscopic examination of the pituitaries showed normal morphology at 4 months of age, either unremarkable morphology or microadenoma formation at 9 months of age, and up to 5 mm large adenomas in clinically ill transgenic mice at 13-16 months of age. At age 9 months, transgenic mice weighed significantly more than corresponding control mice, but they began wasting at approximately 1 year of age. The adrenal glands of these older PyLT-1 mice showed a weight increase and exhibited a medullary hyperplasia. Subcutaneous transplants of transgenic pituitary tumors to nontransgenic, immunocompetent mice resulted in tumors with a morphology and ACTH immunoreactivity similar to the primary tumor. The effects of hypercorticotropism were more enhanced and occurred with a shorter latency in the mice carrying transgene pituitary transplants than in the PyLT-1 transgenic mice themselves. Moreover, these transplanted mice showed a weight increase with an axial deposition pattern and hypertrophy of the adrenal cortex that resembled the findings in human Cushing's disease. Plasma ACTH levels were significantly increased in clinically ill transgenic mice and even higher levels were found in the transplant mice. Thus, both murine models should be useful for studying Cushing's disease.
Lifshitz Holography with Isotropic Scale Invariance
Creators: name: Gary, Michael
name: Grumiller, Daniel
name: Prohazka, Stefan
name: Rey, Soo-Jong
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Is it possible for an anisotropic Lifshitz critical point to actually exhibit isotropic conformal invariance? We answer this question in the affirmative by constructing a concrete holographic realization. We study three-dimensional spin-3 higher-spin gauge theory with a z=2 Lifshitz ground state with non-trivial spin-3 background. We provide consistent boundary conditions and determine the associated asymptotic symmetry algebra. Surprisingly, we find that the algebra consists of two copies of the W_3 extended conformal algebra, which is the extended conformal algebra of an isotropic critical system. Moreover, the central charges are given by 3l/(2G). We consider the possible geometric interpretation of the theory in light of the higher spin gauge invariance and remark on the implications of the asymptotic symmetry analysis.
description: 19 pp; v2: minor edits, new refs; v3: added footnote, minor rewordings, to appear in JHEP
Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granula cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide the exception of focal staining in a few gastrointestinal malignancies, including a subpopulation of gastric carcinomas.Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granula cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide the exception of focal staining in a few gastrointestinal malignancies, including a subpopulation of gastric carcinomas.
Suppression of local and systemic responses in streptococcal cell wall-induced acute inflammation of the air pouch by cyclosporine A. Comparison with the effects of two anti-inflammatory bis-benzimidazoles.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Injection of streptococcus group A cell wall-derived peptidoglycan polysaccharide into a subcutaneous air pouch causes local outpouring of neutrophils and macrophages and distant hemopoietic proliferation in spleen and bone marrow. Cyclosponne A (CyA) suppressed neutrophil accumulation and all cell lines of hemopoiesis. trans-1,2-Bis(5-amidino-2-benximidazolyl)ethene (BBE) also interfered with neutrophil exudation, yet reduced only the erythroid component of the hemopoietic process. The ethane analogue of BBE, on the other hand, did not prevent neutrophil emigration, but held down splenic erythropoiesis and myelopoiesis.Injection of streptococcus group A cell wall-derived peptidoglycan polysaccharide into a subcutaneous air pouch causes local outpouring of neutrophils and macrophages and distant hemopoietic proliferation in spleen and bone marrow. Cyclosponne A (CyA) suppressed neutrophil accumulation and all cell lines of hemopoiesis. trans-1,2-Bis(5-amidino-2-benximidazolyl)ethene (BBE) also interfered with neutrophil exudation, yet reduced only the erythroid component of the hemopoietic process. The ethane analogue of BBE, on the other hand, did not prevent neutrophil emigration, but held down splenic erythropoiesis and myelopoiesis.
Mice with hemangiomas induced by transgenic endothelial cells. A model for the Kasabach-Merritt syndrome.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Inoculation of an established endothelial cell line from transgenic mouse hemangiomas (Py-4-1) into histocompatible mice induced vascular tumor formation at the site of infection with 100% frequency. Histological and hematological studies revealed that the mice developed hemangiomas with hematological changes similar to those found in the Kasabach-Merritt syndrome in humans, including hemolytic anemia and thrombocytopenic purpura. Modifications in the red blood cell count, hemoglobin concentration, hematocrit, and platelet count were directly correlated with the size of the hemangioma. Thus transgenic endothelial cell injection into histocompatible mice provides an in vivo model system to study the pathobiology of hemangiomas as well as the investigation of angiogenesis inhibitors.
SCALABLE - D3.1 Description of synthetic structured/unstructured data organization
Creators: name: KUATE, Raphael
name: CUIDARD, Romain
Publisher: name: Zenodo
Year: 2022

description: The main objective of SCALABLE for CS GROUP is the improvement of LaBS deployment in bigger clusters of thousands of cores, achieved by a transfer of performance technology from WaLBerla. Therefore, in this deliverable 3.1, which sums up work conducted under Task 3.1, we focus on the choice of a suitable structured/unstructured data organization for LaBS. We thus present prospective work comparing the two codes LaBS and WaLBerla in many aspects and show that on industrial applications, the structured block data organization used in WaLBerla may not improve LaBS scalability. However, the domain decomposition resulting from the structured block data organization may improve data exchange enhancement in two aspects: a scheduled communication between blocks lying in the same process, and a reduction of the size of the surfaces involved in communication between blocks of different processes. These two points will, respectively, be the future work for the next tasks: Task 3.2 “Development of appropriate scheduling”, and Task 3.3 “Development of appropriate loadbalancing".
The stellar-to-halo mass relations of local galaxies segregates by color
Creators: name: Rodriguez-Puebla, A.
name: Avila-Reese, V.
name: Yang, X.
name: Foucaud, S.
name: Drory, N.
name: Jing, Y. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We derive the stellar-to-halo mass relations, SHMR, of local blue and red central galaxies separately, as well as the fraction of halos hosting blue/red central galaxies. We find that: 1) the SHMR of central galaxies is segregated by color, with blue centrals having a SHMR above the one of red centrals; at logMh~12, the Ms/Mh ratio of the blue centrals is ~0.05, which is ~1.7 times larger than the value of red centrals. 2) The intrinsic scatters of the SHMRs of red and blue centrals are ~0.14 and ~0.11dex, respectively. The intrinsic scatter of the average SHMR of all central galaxies changes from ~0.20dex to ~0.14dex in the 11.3
description: Accepted for publication in ApJ (20/Nov/2014). 23 pages, 16 figures. This version has substantial changes after Referee's report. Parts of Section 5 from our previous version will be publish in a follow-up paper
Letter from the Oxford University Blue Ribbon Club to John Betjemen, March 28, 1971
Creators: name: Groom, S. C.
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Associations, institutions, etc.
valueUri: http://id.worldcat.org/fast/819166
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Oxford University Blue Ribbon Club
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Magdalen College (University of Oxford)
valueUri: http://id.worldcat.org/fast/594022
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945

description: Correspondence between John Betjemen and the Blue Ribbon Club (Oxford University Conservative Association). The President of the Blue Ribbon Club in Oxford University, invites Betjeman as a guest speaker to their annual dinner. Betjeman replies that he cannot make it as he will be away filming, before going to the west and then to Australia. He mentions that it is rare for him to have free time to accept these kind of invitations.
Dynamical Spin Squeezing via Higher Order Trotter-Suzuki Approximation
Creators: name: Zhang, Ji-Ying
name: Zhou, Xiang-Fa
name: Guo, Guang-Can
name: Zhou, Zheng-Wei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here we provide a scheme of transforming the one-axis twisting Hamiltonian into the two-axis twisting one based on high order Trotter-Suzuki Approximation. Compared with the paper [Y. C. Liu et al., Phys. Rev. Lett. 107, 013601 (2011)], our method can reduce the number of controlling cycles from $1000$ to $50$. Moreover, it is also spin number independent and takes shorter optimal evolution time contrast with the method in the work [C. Shen et al., Phys. Rev. A 87, 051801 (2013)]. The corresponding error analysis is also provided.
description: 6 pages, 7 figures
Measurement of the production cross-section of $ψ(2S)\to J/ψ(\toμ^+μ^-)π^+π^-$ in $pp$ collisions at $\sqrt{s}=7$ TeV at ATLAS
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The prompt and non-prompt production cross-sections for $ψ(2S)$ mesons are measured using 2.1 fb$^{-1}$ of $pp$ collision data at a centre-of-mass energy of 7 TeV recorded by the ATLAS experiment at the LHC. The measurement exploits the $ψ(2S)\to J/ψ(\toμ^+μ^-)π^+π^-$ decay mode, and probes $ψ(2S)$ mesons with transverse momenta in the range $10\leq p_T<100$ GeV and rapidity $|y|<2.0$. The results are compared to other measurements of $ψ(2S)$ production at the LHC and to various theoretical models for prompt and non-prompt quarkonium production.
description: 35 pages plus author list + cover pages (58 pages total), 14 figures, 8 tables, submitted to JHEP, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/BPHY-2013-06/
Ex Situ Residual Stress Analysis of Chemical Vapor Deposited Diamond Coated Cutting Tools by Synchrotron X‐Ray Diffraction in Transmission Geometry
Creators: name: Hinzmann, Daniel
name: Böttcher, Katrin
name: Reimers, Walter
name: Uhlmann, Eckart
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::600 Technik::600 Technik, Technologie
subject: chemical vapor deposited diamond
subject: cutting tools
subject: residual stresses

description: When machining difficult‐to‐cut, nonferrous materials, chemical vapor deposited (CVD) diamond–coated cutting tools are applied. The tools’ favorable mechanical property profile is based on the hardness of the coating as well as the adaptability of the substrate. Nevertheless, the reproducibility of machining results and process stability are limited by insufficient coating adhesion. The resulting cutting tool failure is based on coating delamination initiated by crack development. By assessing residual stress as an influence of coating adhesion, an analysis of CVD diamond–coated tools is performed using synchrotron X‐ray diffraction in transmission geometry. Investigation of a nanocrystalline and multilayer morphology on cobalt‐based tungsten carbide (WC‐Co) and a silicon nitride–based ceramic (Si3N4) provides the distribution of the principal in‐plane residual stress tensor component σ22 depending on the coating morphology and substrate material. Contrary to microcrystalline CVD diamond, nanocrystalline layers decrease the compressive residual stress. In addition, the CVD diamond coating deposited on the Si3N4 substrate material tends to induce an overall initial tensile residual stress that leads to increased tool performance compared to WC‐Co‐based coated tools. Variation of the coating morphology as well as the substrate material offers the possibility to extend the current model for residual stress–dependent tool failure.
Investigation of Low-Cost Sensors for Particulate Matter and Gases for the Application in Measuring Ambient Air Quality
Creators: name: Samad, Abdul
name: Obando, Daniel
name: Solis, Grecia
name: Laquai, Bernd
name: Vogt, Ulrich
Publisher: name: Zenodo
Year: 2023
Subjects: Low cost sensor, PM particulate matter, gas sensors, dryer, hygroscopic growth, dependency on water vapor and fog

description: • Low number of air quality monitoring stations available due to expensive measurement devices and high maintenance • Few monitoring stations do not provide information on the spatial distribution of air pollutants • Low-Cost sensors can prove the solution to measure the spatial and temporal variability of air pollution • Small, mobile and cost-effective measuring sensors are offered • These sensors could be used to map cities with the spatial distribution of air pollutants • These sensors may not be as accurate as professional equipment, however, the quality of these sensors is constantly being improved • Potential low-cost sensors available for air quality monitoring were investigated for their data quality
Minimal 3+2 sterile neutrino model at LBNE
Creators: name: Hollander, David
name: Mocioiu, Irina
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we examine the sensitivity of the Long Baseline Neutrino Oscillation Experiment to the inclusion of two new sterile neutrino flavors with masses in the eV range. We implement a model with a modified Casas-Ibarra parametrization which can accommodate medium scale mass eigenstates and introduces a new complex mixing angle. We explore the new mixing angle parameter space and demonstrate how LBNE can be used to either provide evidence for or rule out a particular model of sterile neutrinos. Certain three-flavor CP-violation scenarios cannot be distinguished from the sterile neutrinos. Constraints from the Daya Bay reactor experiment and T2K are used to help lift this degeneracy.
description: 14 pages, 17 figures v2: 17 pages, numerical corrections for figures 4 and 5, updated references and minor text changes v3: version as it appears in publication
title: “Volo ergo cogito”. Scoto e la nascita del soggetto
Creators: name: Todisco , Orlando
Publisher: name: Roma Tre-Press
Year: 2010

description: Alla linea interpretativa, incentrata sul primato della ragione, prevalente in Occidente, Scoto contrappone una linea che si ispira al primato della volontà, sia divina che umana, grazie a cui egli ci aiuta a distinguere la logica della ragione che "raccoglie" in unità, dalla lagica della volontà che "accoglie" nell'unità; la prima, che si esprime nell'identità, dalla seconda, che si esalta nella differenza. È un contributo rilevante alla definizione di logos, liberale e amante, di cui il mondo è un'espressione, tra le infinite possibili, e dell'uomo, progettato in modo che lasci un segno del suo passaggio nel tempo. In breve, ciò che si cerca di mettere in evidenza è la volontà come paradigma di libertà creativa, volto trascendente di Dio e tratto essenziale dell'uomo.

description: B@belonline vol. 9 Scienza e sapienza nel Medioevo. Agostinismo e aristotelismo a confronto
Derivation of phenobarbital-responsive immortal rat hepatocytes.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Two lines of rat hepatocytes, designated 6/15 and 6/27, were obtained from carcinogen-treated livers by cultivation in medium containing the liver tumor promoter, phenobarbital (PB). Both lines appeared to be PB-responsive and to have an unlimited in vitro proliferative lifespan, i.e., immortality. The ability of pure 6/27 hepatocytes to form colonies from single cells was strictly dependent upon PB; it was reduced by 97 to 99% in the absence of PB. These hepatocytes were not tumorigenic. For 6/27 hepatocytes in early passages where cultures contained fibroblast contaminants and later when they were a pure culture, PB was able to enhance colony growth from single cells and facilitated population expansion by sustaining DNA synthesis and by inhibiting cell lysis. The 6/15 line displayed PB-dependent colony formation and was not tumorigenic at early passages. At later passages 6/15 hepatocytes were less dependent on PB for colony formation, and they formed hepatocellular carcinoma when transplanted into livers of syngeneic rats. The demonstration that PB sustained the proliferation and viability of hepatocytes with enhanced growth capacity and indefinite proliferative lifespan suggests that PB may be necessary for progression of these chemically initiated hepatocytes to immortal and tumorigenic lines in vitro.
Austria: Bibliographical database of Austrian journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Eberwein, Tobias
name: Krakovsky, Christina
name: Oggolder, Christian
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
Bulgaria: Bibliographical database of Bulgarian journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Raycheva, Lilia
name: Miteva, Nadezhda
name: Velinova, Neli
name: Zankova, Bissera
name: Metanova, Lora
name: Pesheva, Velina
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
Argument Ranking with Categoriser Function
Creators: name: Pu, Fuan
name: Luo, Jian
name: Zhang, Yulai
name: Luo, Guiming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Recently, ranking-based semantics is proposed to rank-order arguments from the most acceptable to the weakest one(s), which provides a graded assessment to arguments. In general, the ranking on arguments is derived from the strength values of the arguments. Categoriser function is a common approach that assigns a strength value to a tree of arguments. When it encounters an argument system with cycles, then the categoriser strength is the solution of the non-linear equations. However, there is no detail about the existence and uniqueness of the solution, and how to find the solution (if exists). In this paper, we will cope with these issues via fixed point technique. In addition, we define the categoriser-based ranking semantics in light of categoriser strength, and investigate some general properties of it. Finally, the semantics is shown to satisfy some of the axioms that a ranking-based semantics should satisfy.
Measurement of Sorption Heat in Laboratory and Field Tests in Comparison with Hygrothermal Simulations
Creators: name: Flexeder, Nina
name: Nouman, Ahmad S.
name: Hepf, Christian
Publisher: name: Technical University of Munich
Year: 2022
Subjects: heat of sorption, monitoring, hygrothermal experiments, material surface

description: The temperature changes after moisture jumps on different material surfaces were demonstrated in laboratory tests. These phenomena (latent heat effects) also occur with gradual moisture changes but less pronounced amplitudes. Especially measurements in field tests, therefore, require methods that can record very small temperature differences without environmental influences. The measuring technique developed for this purpose shows promising results for measurements on different wood surfaces and might allow conclusions about the transient hygroscopic behavior. Although, we found limitations in the measurement method in the case of increased air velocities on the component surface.
SCALABLE - D3.2 Development of appropriate scheduling
Creators: name: Cuidard, Romain
name: Billière, Julien
Publisher: name: Zenodo
Year: 2023

description: The main objective of SCALABLE for CSGROUP is the improvement of LaBS deployment in bigger clusters of thousands of cores, achieved by a transfer of performance technology from WaLBerla. Therefore, in the earlier work package 3.1, we investigated the choice of an appropriate data structure organization for LABS. In this work package 3.2 and following the earlier work, we focus on the choice of an appropriate scheduling for LABS. We have implemented a “delaying” of some computations and obtained significant gains on overall simulation elapsed time. We have also examined the possibility of scheduling LABS simulation steps in terms of independently organized families and show that it would not improve significantly the simulation cost. In the other hand, the observations on the improvement of LABS amount of pdf (particle distribution functions) data exchanged examined in the earlier work package have been generalized and thus implemented at the Scheduling level.
Undifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasia.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Nasopharyngeal carcinoma (NPC) samples of distinct histological types, including squamous cell carcinoma (WHO type 1), nonkeratinizing carcinoma (WHO type 2), and undifferentiated carcinoma (WHO type 3), were analyzed for Epstein-Barr virus (EBV) infection and gene expression by using in situ and biochemical techniques. The EBV-encoded RNAs (EBER) were detected in situ in most tumor cells of all three WHO types of NPC. In foci of squamous differentiation and keratinization within less differentiated NPC and throughout the expanse of well differentiated squamous cell carcinoma, EBER expression was less abundant. Latent membrane protein, an EBV-encoded membrane protein, was detected in 72% (36/50) of all NPC and 67% (6/9) of the cases of squamous cell carcinoma. The EBV genomes were present as clonal episomal forms, without detectable linear viral DNA, in all cases of squamous cell carcinoma analyzed. Polymerase chain reaction amplification of cDNA detected EBV transcription for Epstein-Barr nuclear antigen 1, latent membrane proteins 1 and 2, and BamHI A in all samples, indicating that all forms of NPC express the same EBV genes. These results reveal that EBER expression is significantly decreased in areas with squamous differentiation and confirm that all types of NPC, regardless of histological type or differentiation contain clonal episomal EBV genomes, express specific EBV genes and are a clonal expansion of EBV-infected cells.
Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The pathogenesis of vasculitis associated with anti-neutrophil cytoplasmic antibodies is not established. The anti-neutrophil cytoplasmic antibody autoanigens proteinase 3 (PR3) and elastase induce detachment and cytolysis of endothelial cells in vitro. We investigated whether PR3 and elastase trigger endothelial cell apoptosis. Primary bovine pulmonary artery endothelial cells were treated with either PR3, elastase, or myeloperoxidase (MPO) and apoptosis assessed by four different methods. By the cell death detection enzyme-linked immunosorbent assay, DNA fragmentation increased to 208 +/- 84% or 153 +/- 27% of control with 1 micrograms/ml PR3 or elastase at 24 hours. By ultraviolet light microscopy, the percentage of apoptotic cells significantly increased (P < 0.05) with 5 or 10 micrograms/ml PR3 and 25 or 50 micrograms/ml elastase at 6, 12, or 24 hours. Values at the 24-hour time point are 15.3 +/- 6.4% or 25.8 +/- 6.6% for 5 or 10 micrograms/ml PR3 and 13.9 +/- 3.6% or 20.7 +/- 1.8% for 25 or 50 micrograms/ml elastase compared with 2.2 +/- 1.2% for control. Similarly, with flow cytometry, 5 or 10 micrograms/ml PR3 and 25 or 50 micrograms/ml elastase for 6, 12, or 24 hours demonstrated increasing apoptosis in a dose- and time-dependent manner with the highest values achieved at 24 hours (23.4 +/- 4.0% and 35.6% for 5 and 10 micrograms/ml PR3 and 31.8 +/- 4.0% and 47.8% for 25 and 50 micrograms/ml elastase compared with 7.9 +/- 2.2% in control). Typical DNA laddering was apparent from 6 to 24 hours at 5 or 10 micrograms/ml PR3 and 25 or 50 micrograms/ml elastase. Myeloperoxidase did not induce cell apoptosis. Release of PR3 and elastase by activated neutrophils during acute inflammation, including anti-neutrophil cytoplasmic antibody-associated vasculitis, may result in vascular damage by endothelial cell apoptosis.
title: Adaptive knowledge dynamics and emergent artificial societies: ethnographically based multi-agent simulations of behavioural adaptation in agro-climatic systems
Creators: name: Bharwani, Sukaina
Publisher: name: University of Kent
Year: 2022

description: The goal of this research is to enhance an ethnographic understanding of agricultural adaptation to environmental change, within the context of an anthropological theory of 'adaptive dynamics' [Bennett, 1976], using computer-based techniques. An agent-based model was developed to investigate the 'transitional' adaptive strategies of farmers in south-east England based on data collected during fieldwork. Using ethnographic evidence, the model included the interactions of differing structures of knowledge relating to possible environmental change. This resulted in a variety of adaptive, non-adaptive and indeed mal-adaptive responses by agents in the system and thus, differing degrees of success for individual actors and the group as a whole. The choices made in response to change and their consequences were analysed. Success was measured in terms of minimising vulnerability, achieving sustainable adaptation and meeting economic objectives. Adaptive responses classified using criteria proposed by John W. Bennett [1976], under the heading of adaptive dynamics and incorporated within an agent-based model, allowed a refined understanding of the ethnographic data that was collected exposing new insights and areas for further investigation. The agent-based model illustrated the importance of Bennett's model in illuminating the benefits of indigenous strategies for successful adaptation and sustainability. The broad scope of this research means that it is aimed at an interdisciplinary audience. It is organised such that each chapter will contain a general introductory overview which requires little specialist knowledge, while further reading will entail greater technical detail, which will assume some specialist knowledge. Specialist areas covered include simulation toolkits, declarative programming software and social science research methodologies amongst others. This research is intended to be a guide for non-computing anthropologists to understand the potential in developing simple computer models to complement and support their traditional research methods. Experienced modellers may also benefit from specific techniques described from the social sciences domain, such as the participatory knowledge engineering process developed using ethnographic techniques, which may enhance conventional modelling approaches.
Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Intermediate filaments have been used as cell-type-specific markers in differentiation and pathology; however, recent reports have demonstrated the coexpression of vimentin (a mesenchymal marker) and keratins (epithelial markers) in numerous neoplasms, including melanoma, which has been linked to metastatic disease. To test the hypothesis that coexpression of vimentin and keratins by melanoma cells contributes to a more migratory and invasive phenotype, we co-transfected a vimentin-positive human melanoma cell line, A375P (of low invasive ability), with cDNAs for keratins 8 and 18. The resultant stable transfectants expressed vimentin- and keratin-positive intermediate filaments and showed a two- to threefold increase in their invasion of basement membrane matrix and migration through gelatin in vitro. These findings were further corroborated by video cinematography. During attachment and spreading on fibronectin, the transfectants containing vimentin and keratins 8 and 18 demonstrated an increase in focal adhesions that stained positive for β1 integrin and phosphotyrosine, along with enhanced membrane ruffling and actin stress fiber formation. From these data, we postulate that coexpression of vimentin and keratins results in increased cytoskeletal interactions at focal contacts within extracellular matrices involving integrin cell signaling events, which contributes to a more migratory behavior.
Laplacian spectral characterization of dumbbell graphs and theta graphs
Creators: name: Liu, Xiaogang
name: Lu, Pengli
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C50

description: Let $P_n$ and $C_n$ denote the path and cycle on $n$ vertices respectively. The dumbbell graph, denoted by $D_{p,k,q}$, is the graph obtained from two cycles $C_p$, $C_q$ and a path $P_{k+2}$ by identifying each pendant vertex of $P_{k+2}$ with a vertex of a cycle respectively. The theta graph, denoted by $Θ_{r,s,t}$, is the graph formed by joining two given vertices via three disjoint paths $P_{r}$, $P_{s}$ and $P_{t}$ respectively. In this paper, we prove that all dumbbell graphs as well as theta graphs are determined by their Laplacian spectra.
Croatia: Bibliographical database of Croatian journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Trbojević, Filip
name: Vozab, Dina
name: Nenadić, Iva
name: Peruško, Zrinjka
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
More On Nonrelativistic Diffeomorphism Invariance
Creators: name: Andreev, Oleg
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Certain aspects of nonrelativistic diffeomorphisms in 2+1 dimensions are investigated. These include a nonrelativistic limit of some relativistic actions in 3 dimensions, the Seiberg-Witten map, a modification of the viscosity tensor in particular due to a non-uniform magnetic field, a redefinition of background fields, and 1/R terms on Riemann surfaces of constant curvature.
description: 19 pages. v2: minor changes, reference added; v3: improved discussion on the Seiberg-Witten map, typos corrected, reference added, version to appear in PRD
High frequency of aberrant p16(INK4A) expression in human breast cancer.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The product of the CDKN2/MTS1 gene, p16(INK4A) (16), inhibits phosphorylation of the retinoblastoma protein, pRB, and thus acts as a negative cell cycle regulator. It is inactivated in a wide range of human malignancies, including breast cancer. Using an immunohistochemical approach, we studied the expression of both p16 and pRB in 104 archival breast tumors, including 63 ductal, 33 lobular, and 8 mixed carcinomas. All specimens except one were evaluable for pRB expression, but only 87 were interpretable for p16 expression, reflecting the lower abundance and greater lability of this protein. Only six tumors showed abnormal RB expression. However, 43 carcinomas (49%) were completely (35) or focally (8) negative for p16. Abnormal p16 expression did not significantly correlate with several histopathological parameters. These findings provide evidence that aberrant p16(INK4A) expression is one of the most common abnormalities in human breast cancer.
Czechia: Bibliographical database of Czech journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Waschková Císařová, Lenka
name: Jansová, Iveta
name: Motal, Jan
name: Milecová, Renáta
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
From monastic to parochial schools north and south of the Miño: notes on rural scribes in 12th-century northwest
Creators: name: Castro Correa, Ainoa
name: Álvarez López, Francisco J.
name: Justo Sánchez, Daniel
Publisher: name: Zenodo
Year: 2022
Subjects: Paleography
Palaeography
Manuscript Studies
Medieval History
Visigothic script
Diplomatics
Cultural History

description: Video, abstract and draft transcripts of the presentations given at the International Medieval Congress, University of Leeds (4-7 July), within the framewok of the ERC project PeopleAndWriting. Session 1338 Writing across Borders Scribal Practices in Galicia and Portugal during the 12th Century Sponsor Research Project ‘The Secret Life of Writing: People, Script, and Ideas in the Iberian Peninsula (900-1200)’ ERC Starting Grant, European Commission. H2020 Grant Agreement No. 850604 Organiser Ainoa Castro Correa, Departamento de Historia Medieval, Moderna y Contemporánea, Universidad de Salamanca Moderator/Chair Wendy Davies, University College London

 Paper a The switch of two kingdoms: an historical approach to the Galician-Portuguese territorial identity up to the 12th century
 (Language: English)
 Daniel Justo Sánchez, Departamento de Historia Medieval, Moderna y Contemporánea, Universidad de Salamanca Paper b Writing across the Miño: (re-)assessing writing practices in Galicia and Portugal before 1200
 (Language: English)
 Francisco Álvarez López, Departamento de Historia Medieval, Moderna y Contemporánea, Universidad de Salamanca Paper c From monastic to parochial schools north and south of the Miño: notes on rural scribes in 12th-century northwest.
 (Language: English)
 Ainoa Castro Correa, Departamento de Historia Medieval, Moderna y Contemporánea, Universidad de Salamanca

 Abstract Around the middle of the 12th century the territories south of the river Miño were finally recognised as the independent Kingdom of Portugal. Afonso Henriques’ determination put an end to the illusory political unity of north-western Iberia which had concealed what in practice was a reality: that the natural border kept apart two different, albeit closely related, territories with their own peculiarities. From this starting point, this session aims to explore the concept of the Galician-Portuguese border as a barrier of identities, delving into the writing practices developed in rural contexts north and south of the river, before and after Portuguese independence.
Chlamydial elementary bodies are translocated on the surface of epithelial cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Infection of eukaryotic cells by intracellular pathogens such as chlamydia requires attachment to the host cell surface. Chlamydia are thought to attach to the tips of microvilli in confluent monolayers of polarized cells. In vitro evidence obtained from migrating epithelial cells suggested that during healing the route of pathogen uptake might be different from that in intact epithelia. The small size of infectious chlamydial elementary bodies (approximately 0.3 microm in diameter) has made it difficult, however, to analyze the early stages of pathogen-host cell interaction in living cells by conventional microscopy. Contrast-enhanced video microscopy was therefore used to examine the earliest events of host-pathogen interaction and test the hypothesis that chlamydial uptake into the healing epithelia can involve translocation over the host cell surface. Observations made in this way were validated by scanning and immunofluorescence microscopy. These studies revealed two fates for chlamydiae taken onto the lamellipodial surface: 1) some chlamydiae were moved in a random fashion on the cell surface or were detached into the culture medium, whereas 2) other chlamydiae were translocated across the lamellipodium in a highly directed manner toward the microvillous perinuclear region. After internalization, these latter chlamydiae were found within intracellular inclusions, which demonstrated that this route of attachment and location of uptake resulted in productive growth.
Halo Mass Dependence of HI and OVI Absorption: Evidence for Differential Kinematics
Creators: name: Mathes, Nigel L.
name: Churchill, Christopher W.
name: Kacprzak, Glenn G.
name: Nielsen, Nikole M.
name: Trujillo-Gomez, Sebastian
name: Charlton, Jane
name: Muzahid, Sowgat
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We studied a sample of 14 galaxies (0.1 < z < 0.7) using HST/WFPC2 imaging and high-resolution HST/COS or HST/STIS quasar spectroscopy of Lya, Lyb, OVI1031, and OVI1037 absorption. The galaxies, having 10.8 < log(M/M_solar) < 12.2, lie within D = 300 kpc of quasar sightlines, probing out to D/R_vir = 3. When the full range of galaxy virial masses and D/R_vir of the sample are examined, 40% of the HI absorbing clouds can be inferred to be escaping their host halo. The fraction of bound clouds decreases as D/R_vir increases such that the escaping fraction is around 15% for D/R_vir < 1, around 45% for 1 < D/R_vir < 2, and around 90% for 2 < D/R_vir < 3. Adopting the median mass log(M/M_solar) = 11.5 to divide the sample into "higher" and "lower" mass galaxies, we find mass dependency for the hot CGM kinematics. To our survey limits, OVI absorption is found in only 40% of the HI clouds in and around lower mass halos as compared to 85% around higher mass halos. For D/R < 1, lower mass halos have an escape fraction of 65%, whereas higher mass halos have an escape fraction of 5%. For 1 < D/R_vir < 2, the escape fractions are 55% and 35% for lower mass and higher mass halos, respectively. For 2 < D/R_vir < 3, the escape fraction for lower mass halos is around 90%. We show that it is highly likely that the absorbing clouds reside within 4 virial radii of their host galaxies and that the kinematics are dominated by outflows. Our finding of "differential kinematics" is consistent with the scenario of "differential wind recycling" proposed by Oppenheimer et al. We discuss the implications for galaxy evolution, the stellar to halo mass function, and the mass metallicity relationship of galaxies.
description: 23 pages, 19 figures, ApJ Accepted