cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Antimalarial Iron Chelator, FBS0701, Shows Asexual and Gametocyte Plasmodium falciparum Activity and Single Oral Dose Cure in a Murine Malaria Model
Creators: name: Hand, Carla Cerami
name: Clark, Martha A.
name: Ferrer, Patricia
name: Sullivan, David J.
name: Rienhoff, Hugh Young
name: Tripathi, Abhai K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by the unsuitable absorption and pharmacokinetic properties of the few available iron chelators. FBS0701, (S)3”-(HO)-desazadesferrithiocin-polyether [DADFT-PE], is an oral iron chelator currently in Phase 2 human studies for the treatment of transfusional iron overload. The drug has very favorable absorption and pharmacokinetic properties allowing for once-daily use to deplete circulating free iron with human plasma concentrations in the high µM range. Here we show that FBS0701 has inhibition concentration 50% (IC50) of 6 µM for Plasmodium falciparum in contrast to the IC50 for deferiprone and deferoxamine at 15 and 30 µM respectively. In combination, FBS0701 interfered with artemisinin parasite inhibition and was additive with chloroquine or quinine parasite inhibition. FBS0701 killed early stage P. falciparum gametocytes. In the P. berghei Thompson suppression test, a single dose of 100 mg/kg reduced day three parasitemia and prolonged survival, but did not cure mice. Treatment with a single oral dose of 100 mg/kg one day after infection with 10 million lethal P. yoelii 17XL cured all the mice. Pretreatment of mice with a single oral dose of FBS0701 seven days or one day before resulted in the cure of some mice. Plasma exposures and other pharmacokinetics parameters in mice of the 100 mg/kg dose are similar to a 3 mg/kg dose in humans. In conclusion, FBS0701 demonstrates a single oral dose cure of the lethal P. yoelii model. Significantly, this effect persists after the chelator has cleared from plasma. FBS0701 was demonstrated to remove labile iron from erythrocytes as well as enter erythrocytes to chelate iron. FBS0701 may find clinically utility as monotherapy, a malarial prophylactic or, more likely, in combination with other antimalarials.
Performance of Localized-Orbital Coupled Cluster Approaches for the Conformational Energies of Longer n-alkane Chains
Creators: name: Santra, Golokesh
name: Martin, Jan M. L.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We report an update and enhancement of the ACONFL (conformer energies of large alkanes [Ehlert, S.; Grimme, S.; Hansen, A. J. Phys. Chem. A 2022, 126, 3521-3535]) dataset. For the ACONF12 (n-dodecane) subset, we report basis set limit canonical CCSD(T) reference data obtained from MP2-F12/cc-pV{T,Q}Z-F12 extrapolation, [CCSD(F12*)-MP2-F12]/aug-cc-pVTZ-F12, and a (T) correction from conventional CCSD(T)/aug-cc-pV{D,T}Z calculations. Then we explored the performance of a variety of single and composite localized-orbital CCSD(T) approximations, ultimately finding an affordable LNO-CCSD(T)-based post-MP2 correction that agrees to 0.008 kcal/mol MAD (mean absolute deviation) with the revised canonical reference data. In tandem with canonical MP2-F12/CBS extrapolation, this was then used to re-evaluate the ACONF16 and ACONF20 subsets for n-hexadecane and n-icosane, respectively. A revised ACONFL set was thus obtained. It was then used to assess the performance of different localized-orbital coupled cluster approaches, such as PNO-LCCSD(T) as implemented in MOLPRO, DLPNO-CCSD (T1) as implemented in ORCA, and LNO-CCSD(T) as implemented in MRCC, at their various accuracy settings. A three-tier LNO-CCSD(T)-based composite scheme disagrees by only 0.02 kcal/mol from the revised ACONFL reference data. When extrapolated to the complete PNO space limit, DLPNO-CCSD(T1, Tight) and a composite method are the best picks among all the localized coupled cluster methods tested for the dodecane conformers. Dispersion-corrected dRPA-based double hybrids perform remarkably well for the ACONFL set. While the revised reference data do not affect any conclusions on the less accurate methods, they may upend orderings for more accurate methods with error statistics on the same order as the difference between reference datasets.
description: Revised MS submitted to JPC A: level of theory for reference calculations upgraded; many other changes
Brief communication: A submarine wall protecting the Amundsen Sea intensifies melting of neighboring ice shelves
Creators: name: Gürses, Özgür
name: Kolatschek, Vanessa
name: Wang, Qiang
name: Rodehacke, Christian B.
Publisher: name: Zenodo
Year: 2019

description: Disintegration of ice shelves in the Amundsen Sea has the potential to cause sea level rise by inducing an acceleration of grounded ice streams. Moore et al. (2018) proposed that using a submarine wall to block the penetration of warm water into the ice shelf cavities could reduce this risk. We use a global sea ice-ocean model to show that a wall shielding the Amundsen Sea below 350 m depth successfully suppresses the inflow of warm water and reduces ice shelf melting. However, the warm water gets redirected towards neighboring ice shelves, which reduces the effectiveness of the wall.
Association of Coagulation Activation with Clinical Complications in Sickle Cell Disease
Creators: name: Delaney, John
name: Brittain, Julia E.
name: Hinderliter, Alan
name: Strayhorn, Dell
name: Desai, Payal
name: May, Ryan
name: Ataga, Kenneth I.
name: Key, Nigel S.
name: Jones, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundThe contribution of hypercoagulability to the pathophysiology of sickle cell disease (SCD) remains poorly defined. We sought to evaluate the association of markers of coagulation and platelet activation with specific clinical complications and laboratory variables in patients with SCD.Design and MethodsPlasma markers of coagulation activation (D-dimer and TAT), platelet activation (soluble CD40 ligand), microparticle-associated tissue factor (MPTF) procoagulant activity and other laboratory variables were obtained in a cohort of patients with SCD. Tricuspid regurgitant jet velocity was determined by Doppler echocardiography and the presence/history of clinical complications was ascertained at the time of evaluation, combined with a detailed review of the medical records.ResultsNo significant differences in the levels of D-dimer, TAT, soluble CD40 ligand, and MPTF procoagulant activity were observed between patients in the SS/SD/Sβ0 thalassemia and SC/Sβ+ thalassemia groups. Both TAT and D-dimer were significantly correlated with measures of hemolysis (lactate dehydrogenase, indirect bilirubin and hemoglobin) and soluble vascular cell adhesion molecule-1. In patients in the SS/SD/Sβ0 thalassemia group, D-dimer was associated with a history of stroke (p = 0.049), TAT was associated with a history of retinopathy (p = 0.0176), and CD40 ligand was associated with the frequency of pain episodes (p = 0.039). In multivariate analyses, D-dimer was associated with reticulocyte count, lactate dehydrogenase, NT-proBNP and history of stroke; soluble CD40 ligand was associated with WBC count and platelet count; and MPTF procoagulant activity was associated with hemoglobin and history of acute chest syndrome.ConclusionsThis study supports the association of coagulation activation with hemolysis in SCD. The association of D-dimer with a history of stroke suggests that coagulation activation may contribute to the pathophysiology of stroke in clinically severe forms of SCD. More research is needed to evaluate the contribution of coagulation and platelet activation to clinical complications in SCD.
CST software
Creators: name: MARSOP
name: ASEMARS
name: E-Agri
name: AGRICAB
name: SIGMA
Publisher: name: GEO Knowledge Hub
Year: 2022

description: CST software is designed to support the development and selection of crop yield forecast models to facilitate national and sub national crop yield forecasting. Time trend analysis of yield statistics is followed by regression or scenario analysis using biophysical indicators to explain yield statistics and search for similar years. Constructed models are used to predict yield of the current growing season.  
The CGMS statistical tool has been developed for the MARS unit of JRC in the framework of several MARS related projects (MARSOP, ASEMARS, E-Agri, AGRICAB and SIGMA). These projects contributed to development of the initial version and a number of subsequent updates. The original objective was to support the national crop yield forecasting activities of the MARS Crop Yield Forecasting System (MCYFS). Later, through EU research project like E-Agri, AGRICAB and SIGMA the CGMS statistical tool has been introduced to other (non)-governmental organizations having a mandate in monitoring and forecasting crop production.  
CST can be used in connection with SPIRITS to combine image processing with statistical crop yield forecast modelling. A selection of ASAP indicators available in the data download page, can also be used as yield proxies in CST.
title: Ποιότητα υπηρεσιών Δημοσίου Τομέα – Μέτρηση ικανοποίησης πολιτών από την διεύθυνση Μεταφορών και Επικοινωνιών Περιφερειακής Ενότητας Χανίων
title: Quality of Public Sector Services – Citizens Satisfaction Measurement from Transportations and Communications Department of the Regional Unit of Chania»
Creators: name: Μπουλταδακη Ζαχαρουλα
Publisher: name: Technical University of Crete
Year: 2024

description:  H Διεύθυνση Μεταφορών και Επικοινωνιών της Περιφερειακής Ενότητας Χανίων ασκεί όλες τις αρμοδιότητες του Τομέα Μεταφορών και Επικοινωνιών που έχουν ανατεθεί στις Περιφέρειες σε τοπικό επίπεδο Νομού. Ετησίως, από τα τέσσερα (4) τμήματα της Διεύθυνσης διεκπεραιώνονται πάνω από 25.000 υποθέσεις πολιτών και επαγγελματιών.
Στόχος της διοίκησης είναι η αναζήτηση πρακτικών βελτίωσης της διοικητικής λειτουργίας για την παροχή ποιοτικότερων υπηρεσιών προς τον πολίτη και τoυς επαγγελματίες (Αντιπροσώπους αυτοκινήτων, εκπαιδευτές υποψηφίων οδηγών, γραφεία διεκπεραιώσεων, μηχανικοί κλπ.). Η δυσκολία που συναντάται είναι στο γεγονός ότι, μέχρι σήμερα, δεν έχει γίνει κάποια προσπάθεια μέτρησης - καταγραφής των απόψεων των συναλλασσόμενων πολιτών/πελατών.
Σκοπός της μεταπτυχιακής εργασίας είναι η διερεύνηση των απόψεων των συναλλασσόμενων πολιτών/πελατών αναφορικά με την ποιότητα των παρεχόμενων σε αυτούς υπηρεσιών. Για  την επίτευξη του σκοπού αυτού θα σχεδιασθούν ειδικά ερωτηματολόγια μέτρησης της ικανοποίησης, τα οποία θα διανεμηθούν στους εξυπηρετούμενους πολίτες/πελάτες κατά τις ημέρες και ώρες λειτουργίας της υπηρεσίας. Στην συνέχεια θα ακολουθήσει η ανάλυση των συγκεντρωμένων δεδομένων με χρήση μεθόδων ανάλυσης δεδομένων και πολυκριτήριας ανάλυσης για τον εντοπισμό των σημείων που χρήζουν περαιτέρω βελτίωσης.
Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome
Creators: name: Wolfe, Michelle
name: Martin, Christopher F.
name: Sandler, Robert S.
name: Galanko, Joseph A.
name: Hoskins, Janelle M.
name: McLeod, Howard L.
name: Ong, Pei-Shi
name: Keku, Temitope O.
name: Coleman, Clint A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundLow-penetrance genetic variants have been increasingly recognized to influence the risk of tumor development. Risk variants for colorectal cancer (CRC) have been mapped to chromosome positions 8q23.3, 8q24, 9p24.1, 10p14, 11q23, 14q22.2, 15q13, 16q22.1, 18q21, 19q13.1 and 20p12.3. In particular, the 8q24 single nucleotide polymorphism (SNP), rs6983267, has reproducibly been associated with the risk of developing CRC. As the CRC risk SNPs may also influence disease outcome, thus in this study, we evaluated whether they influence patient survival.Methodology/Principal FindingsDNA samples from 583 CRC patients enrolled in the prospective, North Carolina Cancer Care Outcomes Research and Surveillance Consortium Study (NC CanCORS) were genotyped for 11 CRC susceptibility SNPs at 6 CRC risk loci. Relationships between genotypes and patient survival were examined using Cox regression analysis. In multivariate analysis, patients homozygous for the CRC risk allele of rs7013278 or rs7014346 (both at 8 q24) were only nominally significant for poorer overall survival compared to patients homozygous for the protective allele (hazard ratio = 2.20 and 1.96, respectively; P<0.05). None of these associations, however, remained statistically significant after correction for multiple testing. The other nine susceptibility SNPs tested were not significantly associated with survival.Conclusions/SignificanceWe did not find evidence of association of CRC risk variants with patient survival.
Attrition among Human Immunodeficiency Virus (HIV)- Infected Patients Initiating Antiretroviral Therapy in China, 2003–2010
Creators: name: Zhu, Hao
name: Eron, Joseph
name: Zhao, Decai
name: Dou, Zhihui
name: Napravnik, Sonia
name: Zhang, Yao
name: Cole, Stephen
name: Zhang, Fujie
name: Liu, Zhongfu
name: Cohen, Myron
name: Wohl, David
name: Ma, Ye
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundMortality and morbidity from HIV have dramatically decreased in both high- and low-income countries. However, some patients may not benefit from combination antiretroviral therapy (cART) because of inadequate access to HIV care, including attrition after care initiation.Methodology/Principal FindingsThe study population included all HIV-infected patients receiving cART through the Chinese National Free Antiretroviral Treatment Program from 1 January 2003 to 31 December 2010 (n = 106,542). We evaluated retention in HIV care and used multivariable Cox proportional hazard models to identify independent factors predictive of attrition. The cumulative probability of attrition from cART initiation was 9% at 12 months, 13% at 18 months, 16% at 24 months and 24% at 60 months. A number of factors were associated with attrition, including younger age, male gender, and being single or divorced. Patients with higher CD4 cell counts at cART initiation were more likely to drop out of HIV care. The proportion of patients remaining in HIV care increased in more recent calendar years and among patients who initiated modern cART regimens.Conclusions/SignificanceRetention in HIV care is essential for optimizing individual and public health outcomes. Attrition, even the degree observed in our study, can lead to premature morbidity and mortality, and possibly affect further transmission of HIV and HIV resistant drug variants. Effective strategies to promote retention in HIV care programs are needed. In China these strategies may include focusing particularly on younger male patients and those with higher CD4 cell counts at therapy initiation.
Solution based synthesis of mixed phase materials in the Li2TiO3 - Li4SiO4 system
Creators: name: Hanaor, Dorian A. H.
name: Kolb, Matthias H. H.
name: Gan, Yixiang
name: Kamlah, Marc
name: Knitter, Regina
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: As candidate tritium breeder materials for use in the ITER helium cooled pebble bed, ceramic multiphasic compounds lying in the region of the quasi-binary lithium metatitanate- lithium orthosilicate system may exhibit mechanical and physical advantages relative to single phase materials. Here we present an organometallic solution-based synthesis procedure for the low-temperature fabrication of compounds in the Li2TiO3 - Li4SiO4 region and investigate phase stability and transformations through temperature varied X-ray diffraction and scanning calorimetry. Results demonstrate that the metatitanate and metasilicate phases Li2TiO3 and Li2SiO3 readily crystallise in nanocrystalline form at temperatures below 180°C. Lithium deficiency in the region of 5% results from Li sublimation from Li4SiO4 and/or from excess Li incorporation in the metatitanate phase and brings about a stoichiometry shift and product compounds with mixed lithium orthosilicate/ metasilicate content towards the Si rich region and predominantly Li2TiO3 content towards the Ti rich region. Above 1150°C the transformation of monoclinic to cubic γ-Li2TiO3 disordered solid-solution occurs while the melting of silicate phases indicates a likely monotectic type system with a solidus line in the region 1050°-1100°C. Synthesis procedures involving a lithium chloride precursor are not likely to be a viable option for breeder pebble synthesis as this route was found to yield materials with a more significant Li-deficiency exhibiting the crystallisation of the Li2TiSiO5 phase at intermediate compositions.
Autoreactive Effector/Memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage
Creators: name: Wang, Bo
name: Spidale, Nicholas
name: Garland, Alaina
name: Johnson, Mark C.
name: Vincent, Benjamin G.
name: Diz, Ramiro
name: Tisch, Roland
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Islet transplantation provides a “cure” for type 1 diabetes but is limited in part by recurrent autoimmunity mediated by β cell-specific CD4+ and CD8+ T cells. Insight into the T cell receptor (TCR) repertoire of effector T cells driving recurrent autoimmunity would aid the development of immunotherapies to prevent islet graft rejection. Accordingly, we used a multi-parameter flow cytometry strategy to assess the TCR variable β (Vβ) chain repertoires of T cell subsets involved in autoimmune-mediated rejection of islet grafts in diabetic NOD mouse recipients. Naïve CD4+ and CD8+ T cells exhibited a diverse TCR repertoire, which was similar in all tissues examined in NOD recipients including the pancreas and islet grafts. On the other hand, the effector/memory CD8+ T cell repertoire in the islet graft was dominated by one to four TCR Vβ chains, and specific TCR Vβ chain usage varied from recipient to recipient. Similarly, islet graft- infiltrating effector/memory CD4+ T cells expressed a limited number of prevalent TCR Vβ chains, although generally TCR repertoire diversity was increased compared to effector/memory CD8+ T cells. Strikingly, the majority of NOD recipients showed an increase in TCR Vβ12-bearing effector/memory CD4+ T cells in the islet graft, most of which were proliferating, indicating clonal expansion. Importantly, TCR Vβ usage by effector/memory CD4+ and CD8+ T cells infiltrating the islet graft exhibited greater similarity to the repertoire found in the pancreas as opposed to the draining renal lymph node, pancreatic lymph node, or spleen. Together these results demonstrate that effector/memory CD4+ and CD8+ T cells mediating autoimmune rejection of islet grafts are characterized by restricted TCR Vβ chain usage, and are similar to T cells that drive destruction of the endogenous islets.
AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana
Creators: name: Chung, Eui-Hwan
name: Sondek, John
name: Dangl, Jeffery L.
name: Cherkis, Karen A.
name: Temple, Brenda R. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Plants recognize microbes via specific pattern recognition receptors that are activated by microbe-associated molecular patterns (MAMPs), resulting in MAMP-triggered immunity (MTI). Successful pathogens bypass MTI in genetically diverse hosts via deployment of effectors (virulence factors) that inhibit MTI responses, leading to pathogen proliferation. Plant pathogenic bacteria like Pseudomonas syringae utilize a type III secretion system to deliver effectors into cells. These effectors can contribute to pathogen virulence or elicit disease resistance, depending upon the host plant genotype. In disease resistant genotypes, intracellular immune receptors, typically belonging to the nucleotide binding leucine-rich repeat family of proteins, perceive bacterial effector(s) and initiate downstream defense responses (effector triggered immunity) that include the hypersensitive response, and transcriptional re-programming leading to various cellular outputs that collectively halt pathogen growth. Nucleotide binding leucine-rich repeat sensors can be indirectly activated via perturbation of a host protein acting as an effector target. AvrRpm1 is a P. syringae type III effector. Upon secretion into the host cell, AvrRpm1 is acylated by host enzymes and directed to the plasma membrane, where it contributes to virulence. This is correlated with phosphorylation of Arabidopsis RIN4 in vivo. RIN4 is a negative regulator of MAMP-triggered immunity, and its modification in the presence of four diverse type III effectors, including AvrRpm1, likely enhances this RIN4 regulatory function. The RPM1 nucleotide binding leucine-rich repeat sensor perceives RIN4 perturbation in disease resistant plants, leading to a successful immune response. Here, demonstrate that AvrRpm1 has a fold homologous to the catalytic domain of poly(ADP-ribosyl) polymerase. Site-directed mutagenesis of each residue in the putative catalytic triad, His63-Tyr122-Asp185 of AvrRpm1, results in loss of both AvrRpm1-dependent virulence and AvrRpm1-mediated activation of RPM1, but, surprisingly, causes a gain of function: the ability to activate the RPS2 nucleotide binding leucine-rich repeat sensor.
Extending the Energy Framework for Network Simulator 3 (ns-3)
Creators: name: Tapparello, Cristiano
name: Ayatollahi, Hoda
name: Heinzelman, Wendi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The problem of designing and simulating optimal transmission protocols for energy harvesting wireless networks has recently received considerable attention, thus requiring for an accurate modeling of the energy harvesting process and a consequent redesign of the simulation framework to include it. While the current ns-3 energy framework allows the definition of new energy sources that incorporate the contribution of an energy harvester, the integration of an energy harvester component into an existing energy source is not straightforward using the existing energy framework. In this poster, we propose an extension of the energy framework currently released with ns-3 in order to explicitly introduce the concept of an energy harvester. Starting from the definition of the general interface, we then provide the implementation of two simple models for the energy harvester. In addition, we extend the set of implementations of the current energy framework to include a model for a supercapacitor energy source and a device energy model for the energy consumption of a sensor. Finally, we introduce the concept of an energy predictor, that gathers information from the energy source and harvester and use this information to predict the amount of energy that will be available in the future, and we provide an example implementation. As a result of these efforts, we believe that our contributions to the ns-3 energy framework will provide a useful tool to enhance the quality of simulations of energy-aware wireless networks.
description: 2 pages, 4 figures. Poster presented at WNS3 2014, Atlanta, GA
Hole dynamics and spin currents after ionization in strong circularly polarized laser fields
Creators: name: Barth, Ingo
name: Smirnova, Olga
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We apply the time-dependent analytical R-matrix theory to develop a movie of hole motion in a Kr atom upon ionization by strong circularly polarized field. We find rich hole dynamics, ranging from rotation to swinging motion. The motion of the hole depends on the final energy and the spin of the photoelectron and can be controlled by the laser frequency and intensity. Crucially, hole rotation is a purely non-adiabatic effect, completely missing in the framework of quasistatic (adiabatic) tunneling theories. We explore the possibility to use hole rotation as a clock for measuring ionization time. Analysing the relationship between the relative phases in different ionization channels we show that in the case of short-range electron-core interaction the hole is always initially aligned along the instantaneous direction of the laser field, signifying zero delays in ionization. Finally, we show that strong-field ionization in circular fields creates spin currents (i.e. different flow of spin-up and spin-down density in space) in the ions. This phenomenon is intimately related to the production of spin-polarized electrons in strong laser fields [Barth I and Smirnova O 2013 Phys. Rev. A 88 013401]. We demonstrate that rich spin dynamics of electrons and holes produced during strong field ionization can occur in typical experimental conditions and does not require relativistic intensities or strong magnetic fields.
Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage
Creators: name: Kirby, Margaret L.
name: Muller-Borer, Barbara
name: Fox, Raymond
name: Maeda, Nobuyuo
name: Esch, Gwyn
name: Hutson, Mary
name: Jin, Jian Ping
name: Shepherd, Neal
name: Aldina, Rob
name: Anderson, Page
name: Malouf, Nadia N.
name: Bursac, Nenad
name: Hiller, Sylvia
name: Woon, Woohyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming of one cell type into another has been achieved with transduction and over expression of exogenous defined transcription factors emphasizing their role in specifying cell fate. To discover early and novel endogenous transcription factors that may have a role in adult-derived stem cell acquisition of a cardiomyocyte phenotype, mesenchymal stem cells from human and mouse bone marrow and rat liver were co-cultured with neonatal cardiomyocytes as an in vitro cardiogenic microenvironment. Cell-cell communications develop between the two cell types as early as 24 hrs in co-culture and are required for elaboration of a myocardial phenotype in the stem cells 8–16 days later. These intercellular communications are associated with novel Ca2+ oscillations in the stem cells that are synchronous with the Ca2+ transients in adjacent cardiomyocytes and are detected in the stem cells as early as 24–48 hrs in co-culture. Early and significant up-regulation of Ca2+-dependent effectors, CAMTA1 and RCAN1 ensues before a myocardial program is activated. CAMTA1 loss-of-function minimizes the activation of the cardiac gene program in the stem cells. While the expression of RCAN1 suggests involvement of the well-characterized calcineurin-NFAT pathway as a response to a Ca2+ signal, the CAMTA1 up-regulated expression as a response to such a signal in the stem cells was unknown. Cell-cell communications between the stem cells and adjacent cardiomyocytes induce Ca2+ signals that activate a myocardial gene program in the stem cells via a novel and early Ca2+-dependent intermediate, up-regulation of CAMTA1.
Aktuelle Informationen zum Eichensterben und weiteres Vorgehen 2012/13; Waldschutzinfo Nr. 03 / 2012
Creators: name: Langer, Gitta Jutta
name: Bressem, Ulrich
name: Habermann, Michael
Publisher: name: Zenodo
Year: 2012
Subjects: Eichensterben; Quercus

description: Seit dem Spätsommer 2011 werden in Eichenbeständen örtlich schlechte Vitalitätszustände bis hin zu massiven
 Absterbeerscheinungen beobachtet. Hallimasch- und Prachtkäferbefall (Spechtabschläge, Ausbohrlöcher) sind
 auffällige Begleiterscheinungen bei abgängigen Bäumen. Die Heftigkeit und das Ausmaß der Absterbeprozesse
 haben 2011 und 2012 örtlich überrascht.
Opening the era of quasar host studies at high redshift with JWST
Creators: name: Ding, Xuheng
name: Silverman, John D.
name: Onoue, Masafusa
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We measure the host galaxy properties of five quasars with $z\sim 1.6 - 3.5$ selected from SDSS and AEGIS, which fall within the JWST/HST CEERS survey area. A PSF library is constructed based on stars in the full field-of-view of the data and used with the 2-dimensional image modeling tool galight to decompose the quasar and its host with multi-band filters available for HST ACS+WFC3 and JWST NIRCAM (12 filters covering HST F606W to JWST F444W). As demonstrated, JWST provides the first capability to detect quasar hosts at $z>3$ and enables spatially-resolved studies of the underlying stellar populations at $z\sim2$ within morphological structures (spiral arms, bar) not possible with HST. Overall, we find quasar hosts to be disk-like, lack merger signatures, and have sizes generally more compact than typical star-forming galaxies at their respective stellar mass, thus in agreement with results at lower redshifts. The fortuitous face-on orientation of SDSSJ1420+5300A at $z = 1.646$ enables us to find higher star formation and younger ages in the central $2-4$ kpc region relative to the outskirts, which may help explain the relatively compact nature of quasar hosts and pose a challenge to AGN feedback models.
description: 12 pages, 1 table, 6 figures; ApJL accepted; Comments welcome
Pressure-induced Superconductivity in CaC2
Creators: name: Li, Yan-Ling
name: Luo, Wei
name: Zeng, Zhi
name: Lin, Hai-Qing
name: Mao, Ho-kwang
name: Ahuja, Rajeev
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Carbon can exist as isolated dumbbell, one-dimensional (1D) chain, 2D plane, and 3D network in carbon solids or carbon-based compounds, which attributes to its rich chemical binding way, including sp-, sp2-, and sp3-hybridized bonds. Sp2 hybridizing carbon always captures special attention due to its unique physical and chemical property. Here, using evolutionary algorithm in conjunction with ab initio method, we found that under compression, dumbbell carbon in CaC2 can be polymerized firstly into one-dimensional chain and then into ribbon and further into two dimensional graphite sheet at higher pressure. The C2m structure transforms into an orthorhombic Cmcm phase at 0.5 GPa, followed by another orthorhombic Immm phase, which is stabilized at wide pressure range of 15.2-105.8 GPa and then forced into MgB2-type phase with wide range stability up to at least 1 TPa. Strong electron-phonon coupling in cold compressed CaC2 is found, in particular for Immm phase, which has the highest lambda value (0.562-0.564) among them, leading to its high superconducting critical temperature (7.9~9.8 K), wihich is comparable to 11.5K value of CaC6. Our research results show that calcium can not only stabilize carbon sp2 hybridization at larger range of pressure but make them present superconducting behavior, which would further ignite experimental and theoretical research interests on Alkali-Earth metal carbides to uncover their peculiar physical properties under extreme conditions.
description: 34 pages, 4 Tables, 13 figures
Capturing Single Cell Genomes of Active Polysaccharide Degraders: An Unexpected Contribution of Verrucomicrobia
Creators: name: Xie, Gary
name: Swan, Brandon K.
name: Chain, Patrick S. G.
name: Gleasner, Cheryl D.
name: Masland, Dashiell E. D.
name: Arnosti, Carol
name: Lo, Chien-Chi
name: Bellows, Wendy K.
name: Poulton, Nicole J.
name: Ziervogel, Kai
name: Thompson, Brian
name: Reitenga, Krista G.
name: Gomez, Monica Lluesma
name: Stepanauskas, Ramunas
name: Martinez-Garcia, Manuel
name: Ahmed, Sanaa
name: Detter, Chris J.
name: Brazel, David M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Microbial hydrolysis of polysaccharides is critical to ecosystem functioning and is of great interest in diverse biotechnological applications, such as biofuel production and bioremediation. Here we demonstrate the use of a new, efficient approach to recover genomes of active polysaccharide degraders from natural, complex microbial assemblages, using a combination of fluorescently labeled substrates, fluorescence-activated cell sorting, and single cell genomics. We employed this approach to analyze freshwater and coastal bacterioplankton for degraders of laminarin and xylan, two of the most abundant storage and structural polysaccharides in nature. Our results suggest that a few phylotypes of Verrucomicrobia make a considerable contribution to polysaccharide degradation, although they constituted only a minor fraction of the total microbial community. Genomic sequencing of five cells, representing the most predominant, polysaccharide-active Verrucomicrobia phylotype, revealed significant enrichment in genes encoding a wide spectrum of glycoside hydrolases, sulfatases, peptidases, carbohydrate lyases and esterases, confirming that these organisms were well equipped for the hydrolysis of diverse polysaccharides. Remarkably, this enrichment was on average higher than in the sequenced representatives of Bacteroidetes, which are frequently regarded as highly efficient biopolymer degraders. These findings shed light on the ecological roles of uncultured Verrucomicrobia and suggest specific taxa as promising bioprospecting targets. The employed method offers a powerful tool to rapidly identify and recover discrete genomes of active players in polysaccharide degradation, without the need for cultivation.
Non-isothermal direct bundle simulation of SMC compression molding with a non-Newtonian compressible matrix
Creators: name: Meyer, Nils
name: Ilinzeer, Sergej
name: Hrymak, Andrew N.
name: Henning, Frank
name: Kärger, Luise
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: Compression molding of Sheet Molding Compounds (SMC) is a manufacturing process in which a stack of discontinuous fiber-reinforced thermoset sheets is formed in a hot mold. The reorientation of fibers during this molding process can be either described by macroscale models based on Jeffery's equation or by direct mesoscale simulations of individual fiber bundles. In complex geometries and for long fibers, direct bundle simulations outperform the accuracy of state-of-the-art macroscale approaches in terms of fiber orientation and fiber volume fraction. However, it remains to be shown that they are able to predict the necessary compression forces considering non-isothermal, non-Newtonian and compaction behavior. In this contribution, both approaches are applied to the elongational flow in a press rheometer and compared to experiments with 23% glass fiber volume fraction. The results show that both models predict contributions to the total compression force and orientation reasonably well for short flow paths. For long flow paths and thick stacks, complex deformation mechanisms arise and potential origins for deviation between simulations models and experimental observations are discussed. Furthermore, Jeffery's basic model is able to predict orientations similar to the high-fidelity mesoscale model. For planar SMC flow, this basic model appears to be even better suited than the more advanced orientation models with diffusion terms developed for injection molding.
Roper Commercial # 47: Ohio Teachers Study
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Teaching personal grooming (1); school responsibility (2); teaching cleanliness (1); curriculum (18); cleanliness teaching materials (1); available teaching aids (16); cleanliness inspection (2); hand washing inspection (1); reasons for clean hands (3); teaching obstacles (8); hand washing facilities (8); pupils using facilities (6); hot water availability (1); providing soap (4); hand-drying facilities (4); hand-drying facilities adequacy (2); toilet locations (4); student population (3).
Cerebrospinal Fluid Pressure Decreases with Older Age
Creators: name: Allingham, R. Rand
name: Zaydlarova, Jana
name: Berdahl, John P.
name: Stinnett, Sandra
name: Fautsch, Michael P.
name: Fleischman, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Clinical studies implicate low cerebrospinal fluid pressure (CSFP) or a high translaminar pressure difference in the pathogenesis of primary open angle glaucoma (POAG) and normal tension glaucoma (NTG). This study was performed to examine the effect of age, sex, race and body mass index (BMI) on CSFP.
Colloidal Titanium Nitride Nanobars for Broadband Inexpensive Plasmonics and Photochemistry from Visible to Mid-IR Wavelengths
Creators: name: Rej, Sourav
name: Santiago, Eva Yazmin
name: Baturina, Olga
name: Zhang, Yu
name: Burger, Sven
name: Kment, Stepan
name: Govorov, Alexander O.
name: Naldoni, Alberto
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Developing colloidal plasmonic nanomaterials with high carrier density that show optical resonances and photochemical activity extending from the visible to the mid-infrared (MIR) ranges remains a challenging pursuit. Here, we report the fabrication of titanium nitride (TiN) nanobars obtained using a two step procedure based on a wet chemical route synthesis of TiO2 nanowires and their subsequent high temperature annealing in ammonia flow. Electromagnetic simulations of the resulting TiN nanobars reveal a rich set of optical resonances featuring transverse, longitudinal and mixed transverse longitudinal plasmonic modes that cover energies from the visible to MIR region. TiN nanobars decorated with Pt co catalyst nanocrystals show enhanced photocatalytic hydrogen evolution activity in comparison to both isotropic TiN nanospheres of similar size and TiN nanocubes under near infrared excitation at 940 nm due to the enhanced hot electron generation. We also demonstrate that plasmonic TiN nanobars can be used for the detection of furfural molecular vibrations by providing a strong surface enhanced infrared absorption (SEIRA) effect in the MIR region.
description: 78 pages, 4 Figures main article, 39 Figures for Supporting Information
Roper Commercial #104: Party Line III -- Public Pulse
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Most important problems (2); education emphasis (1); amount of prosperity (1); reason for price increase (1); nuclear tests (1); communist threat (2); Civil Defense (1); family decisions (1); teenage behavior (1); sex before marriage (1); importance of marital relations (1); alcoholism (1); death sentence (1); best leader (1); worst leader (1); labor union opinion (1); Eisenhower Administration rating (2); government regulation (1); welfare measures (1); Supreme Court opinion (1); congressional investigating committees (1); most efficient armed service (1); black suffrage (1); favorable senators (16); unfavorable senators (16); Catholic president (1); Billy Graham opinion (1); China in the U.N. (1); trading with China (1).
Iris: an Extensible Application for Building and Analyzing Spectral Energy Distributions
Creators: name: Laurino, Omar
name: Budynkiewicz, Jamie
name: D'Abrusco, Raffaele
name: Bonaventura, Nina
name: Busko, Ivo
name: Cresitello-Dittmar, Mark
name: Doe, Stephen M.
name: Ebert, Rick
name: Evans, Janet D.
name: Norris, Patrick
name: Pevunova, Olga
name: Refsdal, Brian
name: Thomas, Brian
name: Thompson, Randy
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Iris is an extensible application that provides astronomers with a user-friendly interface capable of ingesting broad-band data from many different sources in order to build, explore, and model spectral energy distributions (SEDs). Iris takes advantage of the standards defined by the International Virtual Observatory Alliance, but hides the technicalities of such standards by implementing different layers of abstraction on top of them. Such intermediate layers provide hooks that users and developers can exploit in order to extend the capabilities provided by Iris. For instance, custom Python models can be combined in arbitrary ways with the Iris built-in models or with other custom functions. As such, Iris offers a platform for the development and integration of SED data, services, and applications, either from the user's system or from the web. In this paper we describe the built-in features provided by Iris for building and analyzing SEDs. We also explore in some detail the Iris framework and software development kit, showing how astronomers and software developers can plug their code into an integrated SED analysis environment.
description: 18 pages, 8 figures, accepted for publication in Astronomy & Computing
Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice
Creators: name: Willcockson, Helen H.
name: Caron, Kathleen M.
name: Hoopes, Samantha L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryonic lymphatic development. To determine the role of Calcrl in adulthood, we used an inducible Cre-loxP system to temporally and ubiquitously delete Calcrl in adult mice. Following tamoxifen injection, Calcrlfl/fl/CAGGCre-ER™ mice rapidly developed corneal edema and inflammation that was preceded by and persistently associated with dilated corneoscleral lymphatics. Lacteals and submucosal lymphatic capillaries of the intestine were also dilated, while mesenteric collecting lymphatics failed to properly transport chyle after an acute Western Diet, culminating in chronic failure of Calcrlfl/fl/CAGGCre-ER™ mice to gain weight. Dermal lymphatic capillaries were also dilated and chronic edema challenge confirmed significant and prolonged dermal lymphatic insufficiency. In vivo and in vitro imaging of lymphatics with either genetic or pharmacologic inhibition of AM signaling revealed markedly disorganized lymphatic junctional proteins ZO-1 and VE-cadherin. The maintenance of AM signaling during adulthood is required for preserving normal lymphatic permeability and function. Collectively, these studies reveal a spectrum of lymphatic defects in adult Calcrlfl/fl/CAGGCre-ER™ mice that closely recapitulate the clinical symptoms of patients with corneal, intestinal and peripheral lymphangiectasia.
Roper Commercial # 98: Pre-Convention Election Study
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Election interest (1); most important election issues (3); party affiliation (1); elections not voted in (1); 1956 Dwight Eisenhower-Adlai Stevenson election (1); voter participation (1); Ricahrd Nixon-Eisenhower comparison (1); best party for various issues (12); Democratic candidate (2); Republican candidate (2); Presidential candidate preferences (12); disliked candidates (2); candidate quality (2); candidate strong points (18); Summit crisis (2); future world war (1); Catholic president (1).
A probabilistic virtual process chain to quantify process-induced uncertainties in Sheet Molding Compounds
Creators: name: Meyer, Nils
name: Gajek, Sebastian
name: Görthofer, Johannes
name: Hrymak, Andrew
name: Kärger, Luise
name: Henning, Frank
name: Schneider, Matti
name: Böhlke, Thomas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: The manufacturing process of Sheet Molding Compound (SMC) influences the properties of a component in a non-deterministic fashion. To predict this influence on the mechanical performance, we develop a virtual process chain acting as a digital twin for SMC specimens from compounding to failure. More specifically, we inform a structural simulation with individual fields for orientation and volume fraction computed from a direct bundle simulation of the manufacturing process. The structural simulation employs an interpolated direct deep material network to upscale a tailored SMC damage model. We evaluate hundreds of virtual specimens and conduct a probabilistic analysis of the mechanical performance. We estimate the contribution to uncertainty originating from the process-induced inherent random microstructure and from varying initial SMC stack configurations. Our predicted results are in good agreement with experimental tensile tests and thermogravimetric analysis.
Roper Commercial # 126: Speculation
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Amount of prosperity (1); confidence in leaders (2); management concerns (2); domestic companies overseas (3); underdeveloped countries (3); amount of imports (1); import restrictions (4); most interesting article (1); best company for employees (1); future prospects of various industries (8); government inspections (7); amount of profit (3); best research oil companies (1); favorability of various companies (3); Standard Oil companies (1); evaluation of various business practices (14); company heard most about (1); personal investments in companies (3); company-government cooperation (2); most troublesome companies (2); companies involved in multiple branches (18); gasoline brand names (3); stock ownership (1); investment preferences (5); oil company stock ownership (7); automobile ownership (1); preferred gasoline brand (5); company descriptions (30).
Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice
Creators: name: Callaway, Justin B.
name: Ting, Jenny P.-Y.
name: Arthur, Janelle C.
name: Lich, John D.
name: Tilley, Stephen L.
name: Roberts, Reid A.
name: Jania, Corey M.
name: Allen, Irving C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Among the 22 members of the nucleotide binding-domain, leucine rich repeat-containing (NLR) family, less than half have been functionally characterized. Of those that have been well studied, most form caspase-1 activating inflammasomes. NLRP12 is a unique NLR that has been shown to attenuate inflammatory pathways in biochemical assays and mediate the lymph node homing of activated skin dendritic cells in contact hypersensitivity responses. Since the mechanism between these two important observations remains elusive, we further evaluated the contribution of NLRP12 to organ specific adaptive immune responses by focusing on the lung, which, like skin, is exposed to both exogenous and endogenous inflammatory agents. In models of allergic airway inflammation induced by either acute ovalbumin (OVA) exposure or chronic house dust mite (HDM) antigen exposure, Nlrp12−/− mice displayed subtle differences in eosinophil and monocyte infiltration into the airways. However, the overall development of allergic airway disease and airway function was not significantly altered by NLRP12 deficiency. Together, the combined data suggest that NLRP12 does not play a vital role in regulating Th2 driven airway inflammation using common model systems that are physiologically relevant to human disease. Thus, the allergic airway inflammation models described here should be appropriate for subsequent studies that seek to decipher the contribution of NLRP12 in mediating the host response to agents associated with asthma exacerbation.