cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Calque surplombant et ras-du-réseau : temporalités et spatialités du débat historique sur les mobilités grand-parisiennes
Creators: name: Flonneau, Mathieu
Publisher: name: Collectif Inventer le Grand Paris
Year: 2022

description: Je voudrais tout d'abord rebondir sur une question de vocabulaire, récurrente dans les différentes interventions, quant à la terminologie routière. En effet on a du mal à avoir la perception d'une politique routière cohérente, car il n'y a effectivement pas eu de politique routière cohérente jusqu'à une date avancée, et j'en prendrais pour preuve une citation de Paul Delouvrier extraite d'une conférence sur les problèmes des districts de la région de Paris, publiée dans la Revue générale des routes et des aérodromes en 1964. De fait, elle pose historiquement la question du vocabulaire et du sens des problèmes routiers : ...
Pride in progress : an examination of queer shame in Shakespeare's A midsummer night's dream and Twelfth night
Creators: name: Jacobson, Eva Vanderloop
Publisher: name: University of British Columbia
Year: 2023

description: This thesis examines how Shakespeare incorporated early modern social policing and public shaming practices into his plays as a means of demonstrating and critiquing the unique role shame played in the deterrence of socially transgressive, and especially queer, behavior in Elizabethan England. It examines how the apparent disintegration of formerly immutable boundaries in the late-sixteenth and early-seventeenth centuries ignited fears of widespread disorder, leading to an increase in public shaming rituals like charivaris, rough ridings, cartings, and skimingtons. These punishments were carried out by one’s neighbors as a means of instilling order and shaming people who failed to conform to community norms. While, the Introduction will explore the historical context in which Shakespeare produced his plays (briefly outlined above), the ensuing chapters will focus on how shame features in two of Shakespeare’s comedies: A Midsummer Night’s Dream and Twelfth Night. Chapter One examines the methods used by A Midsummer Night’s Dream’s authoritarian male characters—Theseus and Oberon—to control the queer women who resist their rule. It argues that the men’s disastrous attempts to assert their dominance not only fail to effectively shame Hippolyta and Titania but result in potentially catastrophic consequences for the realms the duke and fairy king are supposed to protect. Chapter Two explores the centrality of shame in Twelfth Night and its role in punishing the disorderly behavior of queer characters who allow their transgressive desires to interfere with their obligatory roles in the gender and class hierarchies. It also examines how the Malvolio subplot exposes the myriad flaws in Elizabethan social policing and public shaming practices, as well as the hypocrisy of those who employ such methods to punish their peers. As a whole, this thesis attempts to throw into question the stability and intrinsic value of a social order which relies on the habitual and widespread application of shame for its survival.
A perturbative path integral study of active and passive tracer diffusion in fluctuating fields
Creators: name: Démery, V.
name: Dean, D. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the effective diffusion constant of a Brownian particle linearly coupled to a thermally fluctuating scalar field. We use a path integral method to compute the effective diffusion coefficient perturbatively to lowest order in the coupling constant. This method can be applied to cases where the field is affected by the particle (an active tracer), and cases where the tracer is passive. Our results are applicable to a wide range of physical problems, from a protein diffusing in a membrane to the dispersion of a passive tracer in a random potential. In the case of passive diffusion in a scalar field, we show that the coupling to the field can, in some cases, speed up the diffusion corresponding to a form of stochastic resonance. Our results on passive diffusion are also confirmed via a perturbative calculation of the probability density function of the particle in a Fokker-Planck formulation of the problem. Numerical simulations on simplified systems corroborate our results.
description: 13 pages RevTex, 4 figures
Additional file 1 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Creators: name: Liotti, Federica
name: Kumar, Narender
name: Prevete, Nella
name: Marotta, Maria
name: Sorriento, Daniela
name: Ieranò, Caterina
name: Ronchi, Andrea
name: Marino, Federica Zito
name: Moretti, Sonia
name: Colella, Renato
name: Efiso Puxeddu
name: Paladino, Simona
name: Kano, Yoshihito
name: Ohh, Michael
name: Scala, Stefania
name: Melillo, Rosa Marina
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Supplementary Table 1. Mouse immune cell density (expressed as percentage of CD45+ leukocytes) in 8505c xenografts.
title: Formation and compositional variation in igneous garnets from the Tezhsar Alkaline Complex (Lesser Caucasus, Armenia)
Creators: name: Halama, Ralf
name: Sokół, Krzysztof
name: Meliksetian, Khachatur
name: Savov, Ivan P.
name: Chew, David
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Garnet in alkaline igneous rocks is of interest due to its compositional and textural variability that provides insights into magmatic and hydrothermal processes. This study investigates textures and mineral chemistry of garnets from the Tezhsar Alkaline Complex (Armenia) to constrain their petrogenetic origin by determining whether the garnets are a primary magmatic liquidus phase or whether they have a secondary, subsolidus origin. Element mobility during garnet formation is evaluated, focusing on rare earth elements (REE), for which alkaline igneous rocks are a globally important resource and which are a valuable geochemical tracer to understand the evolution of rock-melt-fluid systems.

In the Tezhsar Alkaline Complex, K-rich plutonic and volcanic rocks occur in concentric units, representing the remnants of a palaeocaldera (Sokół et al., 2018). Garnet occurs in euhedral to subhedral clusters in pegmatitic nepheline syenite and more rarely as phenocrysts in syenites. The calcic garnets have a high Ti content (c. 2-4 wt.% TiO2), which is typical for garnet in alkaline igneous rocks. Garnet in the pegmatitic nepheline syenite is devoid of inclusions and shows only limited chemical variability, interpreted to reflect crystallization from a melt. In the syenite, garnet is rich in mineral inclusions and is interpreted to reflect a metasomatic origin during late/post-magmatic growth. Trace element data is being acquired to constrain the physicochemical conditions of garnet growth and evaluate REE incorporation into garnet.

Reference: Sokół, K. et al., 2018. Lithos 320-321, 172-191.
title: Can we characterize groundwater reservoirs in central Europe from air pressure induced seismic velocity changes?
Creators: name: Kramer, Richard
name: Lu, Yang
name: Bokelmann, Götz
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Given the increasing challenges posed by climate change, especially more frequent and severe droughts experienced globally, effective exploration and management of groundwater resources is essential to ensure a sustainable and resilient society. As part of this effort, it is necessary to acquire comprehensive knowledge of the distribution of significant and readily accessible freshwater reservoirs on continents. This outlines the critical need for an efficient and cost-effective imaging method to assess this vital resource. In response, we propose a novel imaging method that utilizes observations of air-pressure-induced seismic velocity changes. We utilize findings of our study (Kramer et al., 2023) which shows atmospheric tides and their interaction with the groundwater body are the primary cause of sub-daily seismic velocity changes. Analyzing these velocity changes can reveal valuable information on the hydro-geophysical properties of the underlying groundwater body. Building on this knowledge, we introduce this imaging method and apply it to the seismic data collected across South and Central Europe. For this purpose, we use coda-wave-interferometry to investigate four years of continuous data from AlpArray and other locations throughout Europe.

Kramer, R., Lu, Y., & Bokelmann, G. (2023). Interaction of air pressure and groundwater as main cause of sub-daily relative seismic velocity changes. Geophysical Research Letters, 50, e2022GL101298. https://doi.org/10.1029/2022GL101298
An investigation of the close environment of beta Cep with the VEGA/CHARA interferometer
Creators: name: Nardetto, N.
name: Mourard, D.
name: Tallon-Bosc, I.
name: Tallon, M.
name: Berio, P.
name: Chapellier, E.
name: Bonneau, D.
name: Chesneau, O.
name: Mathias, P.
name: Perraut, K.
name: Stee, P.
name: Blazit, A.
name: Clausse, J. M.
name: Delaa, O.
name: Marcotto, A.
name: Millour, F.
name: Roussel, A.
name: Spang, A.
name: McAlister, H.
name: Brummelaar, T. ten
name: Sturmann, J.
name: Sturmann, L.
name: Turner, N.
name: Farrington, C.
name: Goldfinger, P. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: High-precision interferometric measurements of pulsating stars help to characterize their close environment. In 1974, a close companion was discovered around the pulsating star beta Cep using the speckle interferometry technique and features at the limit of resolution (20 milli-arcsecond or mas) of the instrument were mentioned that may be due to circumstellar material. Beta Cep has a magnetic field that might be responsible for a spherical shell or ring-like structure around the star as described by the MHD models. Using the visible recombiner VEGA installed on the CHARA long-baseline interferometer at Mt. Wilson, we aim to determine the angular diameter of beta Cep and resolve its close environment with a spatial resolution up to 1 mas level. Medium spectral resolution (R=6000) observations of beta Cep were secured with the VEGA instrument over the years 2008 and 2009. These observations were performed with the S1S2 (30m) and W1W2 (100m) baselines of the array. We investigated several models to reproduce our observations. A large-scale structure of a few mas is clearly detected around the star with a typical flux relative contribution of 0.23 +- 0.02. Our best model is a co-rotational geometrical thin ring around the star as predicted by magnetically-confined wind shock models. The ring inner diameter is 8.2 +- 0.8 mas and the width is 0.6 +- 0.7 mas. The orientation of the rotation axis on the plane of the sky is PA = 60 +- 1 deg, while the best fit of the mean angular diameter of beta Cep gives UD[V] = 0.22 +- 0.05 mas. Our data are compatible with the predicted position of the close companion of beta Cep. These results bring additional constraints on the fundamental parameters and on the future MHD and asteroseismological models of the star.
description: Paper accepted for publication in A&A (in press)
title: Headward drainage basin expansion drives Miocene incision along the Yangtze River, China
Creators: name: Rohrmann, Alexander
name: Kirby, Eric
name: Schwanghart, Wolfgang
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Along the southeastern margin of the Tibetan Plateau, the onset of rapid fluvial incision during the Miocene is commonly attributed to growth of high topography. Recent recognition of lacustrine strata preserved atop interfluves, however, suggest that headward expansion of river networks drove migration of the topographic divide. Here, we explore the impact of this process on fluvial incision and sediment transport along the Yangtze River. Landscape evolution simulations using TopoToolbox (TTLEM and TVD-FVM) demonstrate that expansion of the Yangtze watershed into previously internally-drained basins since the Late Miocene could be responsible for 1-2 km of fluvial incision. The distribution of modern knickpoints and river profiles are consistent with this hypothesis. We suggest that increased erosive power associated with capture and basin integration drove accelerated incision and sediment transport during the Late Miocene. Progressive captures and integration of sub-basins could have driven punctuated episodes of rapid incision as drainage divides were progressively breached. Our results support the notion that the low-relief landscape atop the eastern Tibetan Plateau was elevated prior to Miocene time, and that basin integration and headward incision into this high-standing plateau drive rapid incision downstream of this former topographic divide.
Temps de discussion 2
Creators: name: Collectif IGP
Publisher: name: Collectif Inventer le Grand Paris
Year: 2022

description: DISCUSSION Cédric Fériel : La banlieue bleue cherche à enterrer ses infrastructures routières, phénomène que l'on observe beaucoup moins à l'est de la région parisienne... Quelle est la capacité de ces acteurs à influencer le paysage de ces infrastructures routières ? Mathieu Flonneau : Oui, en effet. Il y a traitement différencié entre l'est et l'ouest du boulevard périphérique qui procède d’un simple fait chronologique décalé entre ce que vous appelez la banlieue « bleue » et donc symétriquement la banlieue « rouge ». La portion ouest est plus récente et a bénéficié du renouvellement de la culture technique. La doctrine des ingénieurs des Ponts et...
Additional file 2 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Creators: name: Liotti, Federica
name: Kumar, Narender
name: Prevete, Nella
name: Marotta, Maria
name: Sorriento, Daniela
name: Ieranò, Caterina
name: Ronchi, Andrea
name: Marino, Federica Zito
name: Moretti, Sonia
name: Colella, Renato
name: Efiso Puxeddu
name: Paladino, Simona
name: Kano, Yoshihito
name: Ohh, Michael
name: Scala, Stefania
name: Melillo, Rosa Marina
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2: Supplementary Figure 1. Immune checkpoint expression in thyroid cancer (TC) cells. Protein expression levels assessed by western blot (A) and mRNA expression indicated as ΔCt for PD-1, PD-L1 and PD-L2 (B) in H-6040 normal thyroid epithelial cells, PTC-derived cell lines (BcPAP and TPC-1), and ATC-derived cell lines (8505c, CAL62, SW1736, FRO, BHT101, HTH7, OCUT1). A representative western blot experiment is shown. PCR data are presented as mean ± SD of 5 independent experiments.
title: Constraining the interplay of magmatic and hydrothermal processes during ore formation with numerical models
Creators: name: Gruzdeva, Yulia
name: Weis, Philipp
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Future exploration for mineral resources will target greater depths and submarine settings, which is costly and technically challenging. For this development, numerical modeling can be used to identify the governing processes within entire ore-forming systems. Capturing the dynamics of magmatic-hydrothermal interface processes requires to resolve mass and energy fluxes as a continuum that extends beyond the roots of hydrothermal systems and bridges the gaps between fluid flow and magma dynamics. Magma is mobile during intrusion events and can convect until it reaches a crystal lockup due to cooling and crystallization. During this process, the magma reservoir reaches fluid saturation and exsolves metal-bearing magmatic volatiles to the host rock. We developed a consistent formulation for fluid generation and transport in a coupled model for viscous flow according to the Navier-Stokes-Equations and porous flow with Darcy’s Law, using an up-scaled description of volatile release from reservoir to host rock and realistic magma properties from published experimental and modelling works. We explore the consequences of exsolved volatile phases on magma dynamics and its implications on fluid release and ore formation within the host rock. We distinguish three distinct stages during the evolution of magmatic bodies and their associated porphyry copper deposits with a preparation, a brecciation-stockwork-veining and an ore-formation stage.
Detection of elusive Radio and Optical emission from Cosmic-ray showers in the 1960s
Creators: name: Fegan, David J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: During the 1960s, a small but vibrant community of cosmic ray physicists, pioneered novel optical methods of detecting extensive air showers (EAS) in the Earth's atmosphere with the prime objective of searching for point sources of energetic cosmic gamma-rays. Throughout that decade, progress was extremely slow. Attempts to use the emission of optical Cherenkov radiation from showers as a basis for TeV gamma-ray astronomy proved difficult and problematical, given the rather primitive light-collecting systems in use at the time, coupled with a practical inability to reject the overwhelming background arising from hadronic showers. Simultaneously, a number of groups experimented with passive detection of radio emission from EAS as a possible cheap, simple, stand-alone method to detect and characterise showers of energy greater than 10^16 eV. By the end of the decade, it was shown that the radio emission was quite highly beamed and hence the effective collection area for detection of high energy showers was quite limited, diminishing the effectiveness of the radio signature as a stand-alone shower detection channel. By the early 1970s much of the early optimism for both the optical and radio techniques was beginning to dissipate, greatly reducing research activity. However, following a long hiatus both avenues were in time revived, the optical in the early 1980s and the radio in the early 2000s. With the advent of digital logic hardware, powerful low-cost computing, the ability to perform Monte Carlo simulations and above all, greatly improved funding, rapid progress became possible. In time this work proved to be fundamental to both High Energy Gamma-ray Astronomy and Neutrino Astrophysics. Here, that first decade of experimental investigation in both fields is reviewed.
description: 11 pages, 11 figures, Accepted for NIM-A
title: Effects of CO2 and Ocean Mixing on Miocene and Pliocene Temperature Gradients: Strongly reduced seasonality
Creators: name: Lohmann, Gerrit
name: Knorr, Gregor
name: Stepanek, Christian
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Cenozoic climate changes have been linked to tectonic activity and variations in atmospheric CO2 concentrations. Here, we present Miocene and Pliocene sensitivity experiments performed with the climate model COSMOS. The experiments contain changes with respect to paleogeography, ocean gateway configuration, and atmospheric CO2 concentrations, as well as a range of vertical mixing coefficients in the ocean. For the mid-Miocene, we show that the impact of ocean mixing on surface temperature is comparable to the effect of the possible range in reconstructed CO2 concentrations. In combination with stronger vertical mixing, relatively moderate CO2 concentrations of 450 ppmv enable global-mean surface, deep-water, and meridional temperature characteristics representative of mid-Miocene Climatic Optimum (MMCO) reconstructions. The Miocene climate shows a reduced meridional temperature gradient and reduced seasonality. In the case of enhanced mixing, surface and deep ocean temperatures show significant warming of up to 5–10°C and an Arctic temperature anomaly of >12°C. In the Pliocene simulations, the impact of vertical mixing and CO2 is less important for the deep ocean, which we interpret as a different sensitivity dependence on the background state and mixed layer dynamics. We find a significant reduction in surface albedo and effective emissivity for either a high level of atmospheric CO2 or increased vertical mixing. Our mixing sensitivity experiments provide a warm deep ocean via ocean heat uptake. We propose that the mixing hypothesis can be tested by reconstructions of the thermocline and seasonal paleoclimate data indicating a lower seasonality relative to today.
Percepção dos pesquisadores quanto à elaboração de planos de gestão de dados: a experiência do FioPGD
Creators: name: Veiga, Viviane
name: Dib, Simone
name: Penedo, Erick
name: Alves, Aline da Silva
name: Henning, Patrícia
Publisher: name: Zenodo
Year: 2021

description: Apresentação realizada na sessão Pecha Kucha I da 12ª Conferência Luso-Brasileira de Ciência Aberta, formato híbrido, de 13 a 15 de outubro de 2021.
title: Which tools did stonemasons from the Late Bronze Age use to carve stelae of hard rocks from the Iberian Peninsula?
Creators: name: Ferreiro Mählmann, Rafael
name: Araque Gonzalez, Ralph
name: Asmus, Bastian
name: Paniego Diaz, Pablo
name: Richter, Alexander
name: Vintrici, Giuseppe
name: Baptista, Pedro
name: Scheuvens, Dirk
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
This research will put emphasis on a multidisciplinary approach to examine the Iberian stelae of the Late Bronze Age (c. 1200-800 BC) involving petrographic, geochemical, and metallurgic analyses, complemented by experimental archaeology. The petrographic determination of the rock composition of 16 stelae provided evidence that hard magmatic, sedimentary, and meta-sedimentary rocks were used. The rocks were classified as quartz rich granite, leucocratic syenogranite-aplite, meta-arkose, quarzitic wacke, and silicate quartz-sandstone. Regarding the magmatic rocks, the finest available grain size was preferred. The sedimentary and meta-sedimentary rocks were carved on surfaces with a hard ground, a silicate – ferruginous cemented bed or on a joint wall.

For the archaeological experiment, a variety of lithic tools and bronze chisels with various alloys were replicated, based on original Late Bronze Age tools from Portugal and Spain. Some lithic tools were completely inapplicable, while others, for example an amoeboid diablastic and equigranular quartzite (99 % quartz), provided acceptable results. The carving results with bronze chisels were disillusioning, regardless of the alloy composition. A long-ignored iron chisel from the Late Bronze Age site of Rocha do Vigio (Portugal) was studied with metallography. It revealed a medium-high carbon content steel and the replication of this chisel resulted as the only effective tool, provided the edge was hardened. This would establish the introduction of iron technology as a terminus post quem for the group of silicate quartz-sandstone stelae in Extremadura. Indeed, many of Europe´s earliest irons were found in nearby Portugal.

*(DFG-project AR 1305/2-1), https://www.experimentalarchaeology.uni-freiburg.de/
The Phantom of the ‘Responsible Consumer’: Unmasking the Intention–Action Gap with an Indirect Questioning Technique
Creators: name: Kilian, Sven
name: Mann, Andreas
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: socially desirable responding (SDR)
subject: consumer social responsibility (CnSR)
subject: sustainable consumption
subject: indirect questioning
subject: projective techniques
subject: 330
subject: Verbraucherverhalten
subject: Soziale Verantwortung
subject: Nachhaltigkeit

description: Gefördert durch den Publikationsfonds der Universität Kassel
Bigraded Betti numbers of some simple polytopes
Creators: name: Limonchenko, Ivan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: The bigraded Betti numbers b^{-i,2j}(P) of a simple polytope P are the dimensions of the bigraded components of the Tor groups of the face ring k[P]. The numbers b^{-i,2j}(P) reflect the combinatorial structure of P as well as the topology of the corresponding moment-angle manifold \mathcal Z_P, and therefore they find numerous applications in combinatorial commutative algebra and toric topology. Here we calculate some bigraded Betti numbers of the type β^{-i,2(i+1)} for associahedra, and relate the calculation of the bigraded Betti numbers for truncation polytopes to the topology of their moment-angle manifolds. These two series of simple polytopes provide conjectural extrema for the values of b^{-i,2j}(P) among all simple polytopes P with the fixed dimension and number of vertices.
description: 15 pages, LaTex2e. Revisions in v2:(a)new references added;(b)Conjecture 2.7 reformulated and proved as Theorem 2.9 in Section 2
title: Site selection process for the deep geological repository in the Czech Republic
Creators: name: Vencl, Marek
name: Vondrovic, Lukáš
name: Valter, Martin
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The main criterion concerning the planned deep geological repository comprises its long-term safety, which must be ensured for a period of hundreds of thousands of years. Therefore, particular attention is being devoted to the selection of a suitable site for the facility. As far as the Czech Republic is concerned, it is planned that the DGR will be constructed in a suitable crystalline rock mass. Nine potential sites were originally selected for consideration, all of which were subjected to detailed geological survey assessment. The DGR site selection process was preceded by the extensive collection and evaluation of the relevant data covering the detailed site description and assessment of local conditions. Recently, SÚRAO has conducted a huge amount of research at the sites via e.g. field research, terrain reconnaissance, geological mapping, hydrogeological mapping and sampling, geophysical surveys, the measurement of seismic phenomena, etc. As a result of the research, 3D geoscientific models of the rock conditions were created, which allowed for the assessment of the sites. The nine sites were compared based on safety, feasibility and environmental impact studies following which, on 21 December 2020, the government approved the selection of the four sites recommended by SÚRAO – Březový potok, Horka, Hrádek and Janoch. Further research and exploration work aimed at the eventual selection of the final and backup sites will be conducted up to 2028. The result of this complex characterization will be compiled into a set of site descriptive models describing both – geological setting and long-term evolution of the sites.
Additional file 4 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Creators: name: Liotti, Federica
name: Kumar, Narender
name: Prevete, Nella
name: Marotta, Maria
name: Sorriento, Daniela
name: Ieranò, Caterina
name: Ronchi, Andrea
name: Marino, Federica Zito
name: Moretti, Sonia
name: Colella, Renato
name: Efiso Puxeddu
name: Paladino, Simona
name: Kano, Yoshihito
name: Ohh, Michael
name: Scala, Stefania
name: Melillo, Rosa Marina
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 4: Supplementary Figure 3. Signalling pathways downstream PD-1overexpression. A. Expression levels of PD-1 in some clones or mass populations obtained from 8505c cells stably transfection with PD-1, assessed by western blot. A representative experiment is shown. B. Expression levels of phosphorylated forms of BRAF, MEK1/2 and MAPK (p44/p42) in 8505c cells stably transfected with PD-1 or the empty vector, assessed by western blot. A representative experiment is shown. C. Activation of AKT, SRC, S6, S6K, 4EBP1 in 8505c and TPC-1 cells, transiently transfected or not with PD-1 or the relative empty vector, assessed by western blot for their phosphorylated forms. A representative experiment is shown.
Wave functions for dynamically generated resonances; the two $Λ(1405)$ and $Λ(1670)$
Creators: name: Yamagata-Sekihara, J.
name: Nieves, J.
name: Oset, E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we develop a formalism to evaluate wave functions in momentum and coordinate space for the resonant states dynamically generated in a unitary coupled channel approach. The on shell approach for the scattering matrix, commonly used, is also obtained in Quantum Mechanics with a separable potential, which allows one to write wave functions in a trivial way. We develop useful relationships among the couplings of the dynamically generated resonances to the different channels and the wave functions at the origin. The formalism provides an intuitive picture of the resonances in the coupled channel approach, as bound states of one bound channel, which decays into open ones. It also provides an insight and practical rules for evaluating couplings of the resonances to external sources and how to deal with final state interaction in production processes. As an application of the formalism we evaluate the wave functions of the two $Λ(1405)$ states in the $πΣ$, $\bar{K} N$ and other coupled channels. It also offers a practical way to study three body systems when two of them cluster into a resonance.
description: 5pages, 1 figure. To appear in the proceedings of the International Workshop on Chiral Symmetry in Hadrons and Nuclei (Chiral10), Valencia, Spain, Jun 21-24, 2010
title: Magmatic vs. metasomatic ijolite petrogenesis – constraints from the type locality Iivaara, Finland
Creators: name: Sindern, Sven
name: Hakim, Fahmi
name: Fusswinkel, Tobias
name: Ali, Sajjad
name: Kramm, Ulrich
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Complex field relationships and association to alkaline ultramafic rocks, textural diversity and locally marked isotopic heterogeneity of ijolites lead to contrasting petrogenetic concepts for these rocks. They may either be formed by magmatic differentiation from nephelinitic magmas or by assimilation of silicate wall rocks in a carbonatite melt formed after metasomatic reaction during its’ ascent from mantle to crustal levels. We show new petrographic and mineral chemical results from the ijolite type locality, Iivaara. It is the aim of this presentation to set constraints to ijolite formation in the Iivaara alkaline complex and to discuss applicability of contrasting petrogenetic concepts. Pegmatitic growth, comb layering or brecciation indicate ijolite crystallization from a low viscosity and volatile rich melt. Small scale textural heterogeneity reveals locally highly variable crystallization conditions characterized by steep temperature gradients and sudden pressure drop. Irregular clinopyroxene zonation points to repeated disturbance of magmatic crystallization at depth prior to emplacement at the actual erosion level. Veins and matrices of breccia are dominated by clinopyroxene next to titanite and apatite attesting to the high Ca-concentration of a fluid that is violently expelled from the magma. The transitional zone between wall rocks and ijolite, too, is dominated by pyroxenitic compositions. Lack of a clearly defined contact between ijolite and wall rock is in line with the observation of migmatitic textures in high grade fenites, which probably obtained plastic behavior with increasing degree of fenitization. Such fenites with syenitic composition or partial melts of them may have been assimilated by ijolite.
Additional file 3 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Creators: name: Liotti, Federica
name: Kumar, Narender
name: Prevete, Nella
name: Marotta, Maria
name: Sorriento, Daniela
name: Ieranò, Caterina
name: Ronchi, Andrea
name: Marino, Federica Zito
name: Moretti, Sonia
name: Colella, Renato
name: Efiso Puxeddu
name: Paladino, Simona
name: Kano, Yoshihito
name: Ohh, Michael
name: Scala, Stefania
name: Melillo, Rosa Marina
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 3: Supplementary Figure 2. Functional activity of intrinsic PD-1 circuit in TC cells. A. Expression levels of PD-1 in 8505c and TPC1 cells or in 8505c and TPC-1 transiently transfected with pFLAG or pFLAG PD-1, assessed by western blot. A representative experiment is shown. B. Cell cycle distribution of 8505c and TPC-1 cells transiently transfected with pFLAG or pFLAG PD-1, measured by Propidium Iodide (PI) staining by means of Flow Cytometry. The percent of the cells distributed in G0/G1, S, G2/M was indicated in each panel. Representative experiments are shown. C. Percent of apoptotic cells assessed by TUNEL reaction in 8505c and TPC-1 cells transiently transfected with pFLAG or pFLAG PD-1 and treated or not with soluble PD-L1 (sPD-L1 - 1 μg/ml). Data are presented as mean ± SD of 5 independent experiments. D. Cytofluorimetric evaluation of PD-1 expression in 8505c cells treated with siPD-1 (solid lines) or scrambled siCTR (dotted line) (100 nM). A representative experiment is shown. E. Cell cycle distribution of 8505c and TPC-1 cells treated with Nivolumab (Nivo - 10 μg/ml) or control IgG4 (10 μg/ml), measured by Propidium Iodide (PI) staining by means of Flow Cytometry. The percent of the cells distributed in G0/G1, S, G2/M was indicated in each panel. Representative experiments are shown. F. Percent of apoptotic cells assessed by TUNEL reaction in 8505c and TPC-1 cells treated with siPD-1 (100 nM) or Nivolumab (Nivo - 10 μg/ml) or the relative controls. Data are presented as mean ± SD of 5 independent experiments. G. DNA synthesis of 8505c cells transiently transfected with pCMV3, pCMV3 PD-L1 or pCMV3 PD-L2 or treated with anti-PD-L1, anti-PD-L2 blocking antibodies or IgG1 isotype control (10 μg/ml) assessed by BrdU incorporation. Data are presented as mean ± SD of 5 independent experiments. * P<0.05 compared to the relative control.
title: Hydrogen storage in depleted gas fields – THM modelling strategy and preliminary case study results
Creators: name: Roy, Sonu
name: Laredo, Daniel von Reinicke
name: Henk, Andreas
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
In the current global race towards achieving self-sufficiency and sustainability in meeting energy demands with net-zero emissions, hydrogen has emerged as a promising solution. However, hydrogen's volumetric energy density is lower compared to conventional energy sources, and the storage conditions (pressure and temperature) for hydrogen on the surface are expensive and technically challenging.

To overcome the challenge of large-scale hydrogen storage, researchers around the world have proposed storing hydrogen in subsurface geological structures, such as salt caverns and porous reservoir rocks. While hydrogen storage in salt caverns is a more advanced concept, storing hydrogen in porous rocks such as depleted reservoirs and aquifers requires further research attention. This paper outlines a preliminary workflow for a feasibility study on the use of depleted gas reservoirs for hydrogen storage. Two different fields in Germany are used as examples to illustrate the process. One of the case study fields is still producing from the carbonates of the Zechstein Group, while the other is a decommissioned field that previously produced from unconsolidated Neogene sands. The workflow involves creating a static geological model and populating it with petrophysical parameters, followed by dynamic flow simulation for history matching. Hydrodynamical parameters for hydrogen are then introduced to simulate hypothetical storage cycles. A geomechanical model is then created incorporating the pore pressure data and material properties, to assess storage integrity, fault activity, and surface deflection in response to hydrogen filling. Overall, this workflow provides a comprehensive approach to evaluate the potential for hydrogen storage in depleted reservoirs.
Additional file 5 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Creators: name: Liotti, Federica
name: Kumar, Narender
name: Prevete, Nella
name: Marotta, Maria
name: Sorriento, Daniela
name: Ieranò, Caterina
name: Ronchi, Andrea
name: Marino, Federica Zito
name: Moretti, Sonia
name: Colella, Renato
name: Efiso Puxeddu
name: Paladino, Simona
name: Kano, Yoshihito
name: Ohh, Michael
name: Scala, Stefania
name: Melillo, Rosa Marina
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 5: Supplementary Figure 4. Effects of intrinsic PD-1 on SHP2 localization and functions. A. Expression levels of PD-1, phospho-PD-1, SHP2 and phospho-SHP2 in 8505c and TPC-1 cells transiently transfected with pFLAG PD-1 or the empty vector pFLAG, assessed by western blot. A representative experiment is shown. B. Immunofluorescence microscopy of 8505c cells, transiently transfected with pFLAG PD-1 or the empty vector, with antibody specific for SHP2. Arrows indicate the surface signal of SHP2. Bars, 5 μm. A representative experiment is shown. C. Immunofluorescence microscopy of 8505c cells transiently transfected with pCMV6 PD-1-GFP and stained with antibody specific for SHP2, and the merged signal. Arrows indicate the surface signal of SHP2. Bars, 5 μm. A representative experiment is shown. D. Total protein extracts from TPC-1 cells transiently transfected with pFLAG-PD-1 or the empty vector pFLAG were subjected to a pull-down assay using the indicated recombinant proteins or to immunoprecipitation using the indicated antibodies. Proteins were immunoblotted with antibody against SHP2 or GRB2. A representative experiment is shown. E. Total cell protein extracts from 8505c cells transiently transfected with combination of pCEFL H-Ras AU5, pFLAG PD-1 or empty vector (pFLAG + pCEFL) were subjected to immunoprecipitation with anti-phospho tyrosine followed by western blotting with pan (RAS) antibody. A representative experiment is shown, together with the mean densitometric analysis ± SD of 5 independent assays. * P<0.05 compared to the relative control.
Influence of the substrate-induced strain and irradiation disorder on the Peierls transition in TTF-TCNQ microdomains
Creators: name: Solovyeva, Vita
name: Cmyrev, Anastasia
name: Sachser, Roland
name: Huth, Michael
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The influence of the combined effects of substrate-induced strain, finite size and electron irradiation-induced defects have been studied on individual micron-sized domains of the organic charge transfer compound tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ) by temperature-dependent conductivity and current-voltage measurements. The individual domains have been isolated by focused ion beam etching and electrically contacted by focused ion and electron beam induced deposition of metallic contacts. The temperature-dependent conductivity follows a variable range hopping behavior which shows a crossover of the exponent as the Peierls transition is approached. The low temperature behavior is analyzed within the segmented rod model of Fogler, Teber and Shklowskii, as originally developed for a charge-ordered quasi one-dimensional electron crystal. The results are compared with data obtained on as-grown and electron irradiated epitaxial TTF-TCNQ thin films of the two-domain type.
Mitochondrial DNA mutations and interruptions in combination antiretroviral therapy : a retrospective cohort study
Creators: name: Ziada, Adam
Publisher: name: University of British Columbia
Year: 2023

description: HIV therapy has transformed the lives of people living with HIV (PLWH), turning a once lethal condition into a chronic disease that can be carefully managed over a patient’s lifetime. However, PLWH seem to experience accelerated aging, with a reported decrease in lifespan of up to 10 years, as well as earlier onset and higher prevalence of age-related diseases. Many of these diseases have been linked to interruptions in HIV therapy and/or mutations in the mitochondrial DNA (mtDNA). Current theories of aging implicate the gradual accumulation of mtDNA mutations as a driver of biological aging and may provide a mechanism by which interruptions in HIV therapy could lead to an increased occurrence of age-related diseases. These mutations can be somatic (i.e., de novo) mutations, or higher frequency mtDNA variants (i.e., heteroplasmy). My goal was to determine if interruptions in HIV therapy are associated with an increase in mtDNA somatic or heteroplasmic mutations. Blood mtDNA mutations were characterized among participants living with (n = 219) and without (n = 72) HIV, ranging between 1 and 75 years of age, and enrolled in the Children and Women: AntiRetrovirals and Markers of Aging (CARMA) cohort. Participants living with HIV had between 0 and 17 interruptions in HIV therapy. Mutations were measured in a 264bp region of the mitochondrial D-loop, using a single strand unique molecular identifier-based sequencing to detect ultra-rate substitution mutations. Somatic mtDNA substitution mutations were independently associated with older age (p < 0.001), Indigenous ethnicity (p = 0.001), and having a peak HIV viral load ≥100,000 copies/ml among adult participants. Among all participants having exactly two interruptions was associated with a lower somatic mtDNA substitution burden (p = 0.035). The occurrence of heteroplasmy was independently associated with older age (p = 0.002) and smoking (p = 0.05) among all participants, after considering an age-smoking interaction term. Our results are consistent with the current understanding of mitochondrial aging; however, they do not support the hypothesis that interruption in HIV therapy may be driving mutations in the mitochondrial DNA. However, interruptions remain a risk factor for age-related disease and are almost universally discouraged.
title: New advances in particle size and shape measurements using complementary optical technologies based on dynamic image analysis
Creators: name: Klicpera, Andre
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Determination of particle size distribution of sediments and soils is a crucial property in several fields of industry and geoscientific research. The consequence of improper analyses can result in poor product quality, high rejection rates, or incorrect research data.

Most currently used particle sizing methods such as laser diffraction, sieve analysis or microscopy, are established over decades or even centuries and have been deployed in many different fields. However, their significance is often limited due to low resolution, limited capabilities in terms of quality control requirements or simply the lack of particle shape information. The concept of imaging particle analysis is a relatively new technology, dating back to the late 1970s as CCD sensors for capturing and computers for processing image data began to evolve. Further developments such as Dynamic Image Analysis (DIA) based on one or two high-speed cameras provided enhanced access to morphological particle size and shape information in high-resolution and with statistical robustness by a simple measurement of usually less than three minutes.

Here we introduce two new technologies in the context of dynamic image analysis. Designed as a hybrid-laser diffraction particle-analyzer, the Microtrac Sync provides conventional laser-based optics, equipped with a digital camera for precise particle size and shape information.

Another ground-breaking technology comes with the new Camsizer3D. It uses particle tracking technology, allowing to follow each particle of a sample in up to 30 different orientations. The resulting high-resolution 3D dataset provides digital size and shape information of real morphological particle geometries.
Investigating coronal saturation and super-saturation in fast-rotating M-dwarf stars
Creators: name: Jeffries, R. D.
name: Jackson, R. J.
name: Briggs, K. R.
name: Evans, P. A.
name: Pye, J. P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: At fast rotation rates the coronal activity of G- and K-type stars has been observed to "saturate" and then decline again at even faster rotation rates -- a phenomenon dubbed "super-saturation". In this paper we investigate coronal activity in fast-rotating M-dwarfs using deep XMM-Newton observations of 97 low-mass stars of known rotation period in the young open cluster NGC 2547, and combine these with published X-ray surveys of low-mass field and cluster stars of known rotation period. Like G- and K-dwarfs, we find that M-dwarfs exhibit increasing coronal activity with decreasing Rossby number N_R, the ratio of period to convective turnover time, and that activity saturates at L_x/L_bol ~ 10^-3 for log N_R < -0.8. However, super-saturation is not convincingly displayed by M-dwarfs, despite the presence of many objects in our sample with log N_R < -1.8, where super-saturation is observed to occur in higher mass stars. Instead, it appears that a short rotation period is the primary predictor of super-saturation; P <=0.3d for K-dwarfs and perhaps P <=0.2d for M-dwarfs. These observations favour the "centrifugal stripping" model for super-saturation, where coronal structures are forced open or become radiatively unstable as the Keplerian co-rotation radius moves inside the X-ray emitting coronal volume.
description: Accepted for Monthly Notices of the Royal Astronomical Society. 15 pages, 7 figures (electronic tables from the author)