cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Systematic changes in serpentine Si isotope signatures across the Mariana forearc – a new proxy for slab dehydration processes
Creators: name: Geilert, Sonja
name: Albers, Elmar
name: Frick, Daniel A.
name: Hansen, Christian T.
name: Blanckenburg, Friedhelm Von
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Mariana forearc
subject: serpentinization
subject: in situ Si isotopes
subject: slab dehydration
subject: sediment proxy
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: The Mariana forearc is a unique location for exploring the role serpentinization plays in the marine Si cycle by means of Si stable isotope variations. Here, active mud volcanism transports deep, serpentinized mantle wedge material to the surface and thus offers a natural window to slab dehydration processes in dependence of changing temperature and pressure with depth. Si isotopes were measured in situby femtosecond laser ablation MC-ICPMS in serpentine within ultramafic clasts from three mud volcanoes (Yinazao, Fantangisna, and Asut Tesoru) sampled during International Ocean Discovery Program Expedition 366. To corroborate the results, serpentinization of olivine was studied in batch experiments. The Si isotope ratios show large variations between the mud volcanoes and between individual serpentine generations within a given mud volcano. Serpentine that formed early under low water/rock ratios exhibits delta Si-30 of -0.41 +/- 0.04 parts per thousand (1SD) similar to unaltered olivine which agrees well with experimental findings predicting no significant isotope fractionation during early serpentinization. In contrast, late serpentine veins formed under higher water/rock ratios span a wide range of Si isotope ratios that differ significantly between the individual mud volcanoes. With increasing distance to the trench, delta Si-30 of late veins are -0.10 +/- 0.07 parts per thousand, -1.94 +/- 0.13 parts per thousand, and -0.80 +/- 0.22 parts per thousand and -0.93 +/- 0.21 parts per thousand. These delta Si-30 values are interpreted to record the isotopic composition of the fluid source, namely subducted biogenic silica and pore fluids, clays, and altered oceanic crust that dehydrate as consequence of rising pressure and temperature with depth. We show that Si isotopes of mantle wedge serpentinites can be used as a reliable new proxy for slab dehydration processes. They may be used in paleo-forearc systems to unravel oceanic sediment and silica biomineralization evolution through geological time.
Impacto da violência doméstica na saúde mental da mulher durante a gestação e pós-parto: prevenção e abordagem clínica
Creators: name: SILVA, CAROLINE CRISTINA GOMES DA
name: ESPÍRITO SANTO, JONATHAN SALES DO
name: MARTINS, LAÍZA FERREIRA PESSOTTI
name: KRAUZER, ALAIAN SOARES
name: COSTA, GEOVANA CARLA DE GODOY
name: PIMENTA, ISADORA DE MARCHI
name: PEREIRA, JÚLIA MENDONÇA
name: ARANTES, MARINA GABRIELA DE ALMEIDA
name: MARQUES, LUÍZA
name: BARBOSA, FLÁVIA FERNANDES
Publisher: name: Zenodo
Year: 2024

description: PERIÓDICO MÉDICO NÃO INDEXADO Á NENHUMA BASE DE DADOS
A HET-CAM based vascularized intestine tumor model as a screening platform for nano-formulated photosensitizers
Creators: name: Elberskirch, Linda
name: Le Harzic, Ronan
name: Scheglmann, Dietrich
name: Wieland, Gerhard
name: Wiehe, Arno
name: Mathieu-Gaedke, Maria
name: Golf, Hartwig R. A.
name: Briesen, Hagen Von
name: Wagner, Sylvia
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: PLGA-nanoparticles
subject: Liposomes
subject: Pharmaceutical test system
subject: Simulated endoscopic irradiation
subject: Angiogenesis
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The development of new tumor models for anticancer drug screening is a challenge for preclinical research. Conventional cell-based in vitro models such as 2D monolayer cell cultures or 3D spheroids allow an initial assessment of the efficacy of drugs but they have a limited prediction to the in vivo effectiveness. In contrast, in vivo animal models capture the complexity of systemic distribution, accumulation, and degradation of drugs, but visualization of the individual steps is challenging and extracting quantitative data is usually very difficult. Furthermore, there are a variety of ethical concerns related to animal tests. In accordance with the 3Rs principles of Replacement, Reduction and Refinement, alternative test systems should therefore be developed and applied in preclinical research. The Hen's egg test on chorioallantoic membrane (HET-CAM) model provides the generation of vascularized tumor spheroids and therefore, is an ideal test platform which can be used as an intermediate step between in vitro analysis and preclinical evaluation in vivo. We developed a HET-CAM based intestine tumor model to investigate the accumulation and efficacy of nano-formulated photosensitizers. Irradiation is necessary to activate the phototoxic effect. Due to the good accessibility of the vascularized tumor on the CAM, we have developed a laser irradiation setup to simulate an in vivo endoscopic irradiation. The study presents quantitative as well as qualitative data on the accumulation and efficacy of the nano-formulated photosensitizers in a vascularized intestine tumor model.
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry
Creators: name: Großkopf, Henning
name: Vogel, Sarah
name: Damaris Müller, Claudia
name: Köhling, Sebastian
name: Dürig, Jan-Niklas
name: Möller, Stephanie
name: Schnabelrauch, Matthias
name: Rademann, Jörg
name: Hempel, Ute
name: Bergen, Martin Von
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: GAG-biotin
subject: hBMSC
subject: LC-MS/MS
subject: pull-down approach
subject: SaOS2/osteoblast cell line
subject: sulfated glycosaminoglycan derivatives
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). Artificial GAGs like sulfated hyaluronan (sHA) exhibit pro-osteogenic properties and boost healing processes. Hence, they are of high interest for supporting bone regeneration and wound healing. Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative interaction partners is scarce. Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). Overall, 477 proteins were found interacting with at least one of four distinct sGAGs. Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. Respecting the preferentially intracellular localization of sGAG in vesicle-like structures, also the interaction data indicate sGAG-specific modulation of vesicle-based transport processes. By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects.
Supplementary document for Unveiling the relative timing jitter in counter-propagating all-normal dispersion (CANDi) dual-comb fiber laser - 5880366.pdf
Creators: name: Huang, Shu-Wei
name: Prakash, Neeraj
name: Li, Bowen
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Information
Pencil and paper neural networks: an undergraduate laboratory exercise in computational neuroscience
Creators: name: Crisp, Kevin
name: Sutter, Ellen
name: Westerberg, Jacob
Publisher: name: figshare
Year: 2022
Subjects: Neuroscience

description: Although it has been more than 70 years since McCulloch and Pitts published their seminal work on artificial neural networks, such models remain primarily in the domain of computer science departments in undergraduate education. This is unfortunate, as simple network models offer undergraduate students a much-needed bridge between cellular neurobiology and processes governing thought and behavior. Here, we present a very simple laboratory exercise in which students constructed, trained and tested artificial neural networks by hand on paper. They explored a variety of concepts, including pattern recognition, pattern completion, noise elimination and stimulus ambiguity. Learning gains were evident in changes in the use of language when writing about information processing in the brain.
Comparison of mosquito and fly derived DNA as a tool for sampling vertebrate biodiversity in suburban forests in Berlin, Germany
Creators: name: Danabalan, Renita
name: Planillo, Aimara
name: Butschkau, Susanne
name: Deeg, Sita
name: Pierre, Gras
name: Thion, Cincia
name: Calvignac-Spencer, Sébastien
name: Kramer‐Schadt, Stephanie
name: Mazzoni, Camila
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: DNA metabarcoding
subject: iDNA
subject: mammals
subject: mosquito bloodmeal
subject: non‐invasive sampling
subject: urban ecology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The use of invertebrate‐derived DNA (iDNA) is a promising non‐invasive tool to monitor wildlife. While most studies have been carried out in dense tropical and sub‐tropical forests and have focused on the use of a single category of invertebrates, this study compares the use of flies and mosquitoes‐derived DNA to assess vertebrate diversity in semi‐urban environments. We conducted our sampling in four different forest plots in Berlin, Germany. Pools of flies and non‐bloodfed mosquitoes were metabarcoded using 108‐bp vertebrate‐specific 12 S rRNA (12 S‐V5) and 94‐bp mammal‐specific 16 S rRNA (16Smam) mitochondrial markers, and individual bloodfed mosquitoes were sequenced using the 340‐bp vertebrate‐specific 12 S rRNA fragment (Mam‐12 S‐340). Most sequencing was only successful for mammal species. From the fly pools, we detected 10 mammal species using 16Smam, and six species using 12 S‐V5. From the non‐bloodfed mosquito pools, we only amplified putative contaminant DNA, indicating that mosquito females without visual signs of a blood meal carry no traces of vertebrate DNA. Finally, in the bloodfed mosquitoes, we identified four mammal species. We did not find significant differences in the proportion of mammal species detected regarding the total available number of species between sampling localities. Fly samples were easier to obtain and more abundant over the sampled localities compared to mosquito samples. We conclude that, while there are a few advantages in using mosquito blood meals, the use of flies in the detection of wildlife in a suburban environment is more effective in terms of collection of samples and detection of vertebrates, although this technique is limited to few mammal species in the urban environment.
Colectomia parcial em pacientes com diverticulite aguda complicada
Creators: name: OLIVEIRA, MARCELA FERNANDES PEIXOTO DE
name: COSTA, GEOVANA CARLA DE GODOY
name: PIMENTA, ISADORA DE MARCHI
name: PEREIRA, JULIA MENDONÇA
name: BARBOSA, FLÁVIA FERNANDES
name: LEMBRANCE, LARA MACEDO
name: TAVARES, LUDMYLLA BARBOSA
name: BARROSO, BERNARDO ZAIDAN
name: ARANTES, MARINA GABRIELA DE ALMEIDA
name: MARQUES, LUIZA
Publisher: name: Zenodo
Year: 2024

description: PERIÓDICO MÉDICO NÃO INDEXADO Á NENHUMA BASE DE DADOS
The Upper Limit of Denudation Rate Measurement From Cosmogenic 10Be(Meteoric)/9Be Ratios in Taiwan
Creators: name: Deng, Kai
name: Wittmann, Hella
name: Yang, Shouye
name: Blanckenburg, Friedhelm Von
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: meteoric cosmogenic 10Be
subject: erosion and weathering
subject: landslide
subject: soil-bedrock mixing
subject: Taiwan rivers
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: The tectonically active Taiwan orogen features numerous rivers that yield a high amount of sediment with fluxes exceeding 104 t/km2/yr. Amongst these, the landslide-dominated Liwu River is well studied regarding its dynamic surface processes. However, the quantification of denudation in the Liwu Basin is still an ongoing task as rates obtained to date are subject to substantial differences depending on methods that differ in their spatio-temporal scales. We constrain an upper limit of global denudation using the cosmogenic nuclide 10Be(meteoric) and its ratio to stable 9Be. Meteoric cosmogenic 10Be is delivered to Earth’s surface by precipitation, whereas stable 9Be is released from rock weathering. In contrast to in situ cosmogenic 10Be measured in quartz, the 10Be(meteoric)/9Be ratio can be analyzed in quartz-poor settings. 10Be(meteoric)/9Be-derived denudation rates (Dmet) vary from 8.1 to >30 mm/yr in the Liwu mainstem, and from 3.4 to 21.5 mm/yr in the tributaries. These new Dmet are among the highest cosmogenic nuclide-derived rates ever measured. Most of these rates agree with rates from sediment gauging or channel incision. We propose that stochastic landsliding plays a major role in denudation processes here. Using a soil-bedrock mixing model and published riverine organic 14C data as a soil tracer, we estimate the fractional contribution of bedrock landslide material to mainstem sediments to be 55%–97%, which explains the magnitude and large variability (4-fold) in Dmet. We demonstrate the complexity associated with denudation rates determination in landslide-dominated routing systems; but also the potential of 10Be(meteoric)/9Be for tracing stochastic landsliding processes.
River-to-ocean pathways of beryllium-9 through estuaries
Creators: name: Wang, Chenyu
name: Blanckenburg, Friedhelm Von
name: Lian, Ergang
name: Yang, Shouye
name: Perez, Jeffrey Paulo H.
name: Wittmann, Hella
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Beryllium-9
subject: Changjiang Estuary
subject: Pathways
subject: Benthic flux
subject: Hypoxia
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Estuarine processes are key in modulating the riverine input of particle-reactive trace elements to the ocean. An important, but still under-utilized member of these elements is beryllium-9 (9Be) that together with cosmogenic 10Be has been suggested to serve as a quantitative tracer of present and past continental weathering flux. This study investigates different pathways of terrigenous 9Be through coastal areas into the ocean, based on dissolved 9Be concentrations in surface and bottom waters together with corresponding particulate 9Be concentrations along the salinity gradient in the Changjiang Estuary. Dissolved 9Be in the Changjiang Estuary shows a non-conservative behavior: At low to mid-salinity where water is well-mixed, 9Be is removed from both surface and bottom waters at low salinity and then released back into the water column at mid-salinity. At high salinity where water is stratified, dissolved 9Be is removed from surface waters, but is released back into bottom waters. In combination with hydrochemical (e.g., dissolved oxygen) and particulate 9Be data obtained from different extracted phases, we attribute the removal of dissolved 9Be at low salinity to salt-induced colloidal flocculation, whereas in surface waters at high salinity, we ascribe the removal to biological scavenging facilitated by phytoplankton blooms. The release of 9Be into mid- and high-salinity bottom waters is likely dominated by benthic processes, including porewater diffusion and/or submarine groundwater discharge. The contribution from desorption of 9Be from suspended particulate matter is negligible throughout the entire estuary. We propose that the release of 9Be through benthic processes potentially presents the most important contributor to the marine 9Be budget, where this benthic flux of 9Be is likely enhanced by hypoxic conditions in coastal bottom waters.
3D shear wave velocity imaging of the subsurface structure of granite rocks in the arid climate of Pan de Azúcar, Chile, revealed by Bayesian inversion of HVSR curves
Creators: name: Trichandi, Rahmantara
name: Bauer, Klaus
name: Ryberg, Trond
name: Heit, Benjamin
name: Araya Vargas, Jaime
name: Blanckenburg, Friedhelm Von
name: Krawczyk, Charlotte M.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: seismic methods
subject: subsurface
subject: weathering zone
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Seismic methods are emerging as efficient tools for imaging the subsurface to investigate the weathering zone. The structure of the weathering zone can be identified by differing shear wave velocities as various weathering processes will alter the properties of rocks. Currently, 3D subsurface modelling of the weathering zone is gaining increasing importance as results allow the identification of the weathering imprint in the subsurface not only from top to bottom but also in three dimensions. We investigated the 3D weathering structure of monzogranite bedrock near the Pan de Azúcar National Park (Atacama Desert, northern Chile), where the weathering is weak due to the arid climate conditions. We set up an array measurement that records seismic ambient noise, which we used to extract the horizontal-to-vertical spectral ratio (HVSR) curves. The curves were then used to invert for 1D shear wave velocity ( Vs) models, which we then used to compile a pseudo-3D model of the subsurface structure in our study area. To invert the 1D Vsmodel, we applied a transdimensional hierarchical Bayesian inversion scheme, allowing us to invert the HVSR curve with minimal prior information. The resulting 3D model allowed us to image the granite gradient from the surface down to ca. 50 m depth and confirmed the presence of dikes of mafic composition intruding the granite. We identified three main zones of fractured granite, altered granite, and the granite bedrock in addition to the mafic dikes with relatively higher Vs. The fractured granite layer was identified with Vsof 1.4 km s -1at 30–40 m depth, while the granite bedrock was delineated with Vsof 2.5 km s -1and a depth range between 10 and 50 m depth. We compared the resulting subsurface structure to other sites in the Chilean coastal cordillera located in various climatic conditions and found that the weathering depth and structure at a given location depend on a complex interaction between surface processes such as precipitation rate, tectonic uplift and fracturing, and erosion. Moreover, these local geological features such as the intrusion of mafic dikes can create significant spatial variations to the weathering structure and therefore emphasize the importance of 3D imaging of the weathering structure. The imaged structure of the subsurface in Pan de Azúcar provides the unique opportunity to image the heterogeneities of a rock preconditioned for weathering but one that has never experienced extensive weathering given the absence of precipitation.
Lithium isotopes in water and regolith in a deep weathering profile reveal imbalances in Critical Zone fluxes
Creators: name: Cai, Di
name: Henehan, Michael J.
name: Uhlig, David
name: Blanckenburg, Friedhelm Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Lithium budget
subject: Chemical weathering
subject: Black Forest
subject: Secondary mineral formation
subject: Cation exchange
subject: Hydrological budget
subject: Groundwater
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: To trace Critical Zone processes and to quantify Li fluxes from one Critical Zone compartment into another, we investigated the Li concentration and isotopic composition (δ7Li) of time-series water samples (including subsurface flow, groundwater and creek water), vegetation, bedrock (including separated minerals from bedrock), and regolith (including exchangeable fraction and clay-sized fraction of regolith) in a temperate forested headwater catchment in the Black Forest, Conventwald, Germany. Our estimation of the Li budget shows that atmospheric deposition and biological processes played minor roles in the Li cycle relative to chemical weathering. All water samples (δ 7Li value of 6.5 to 20.4 ‰) were enriched in 7Li compared to bedrock (-1.3 ‰) and regolith (∼-1.7 ‰), but δ7Li differed between water pathways: δ7Li variations in subsurface flow, creek water and groundwater were controlled by conservative mixing, exchangeable pool buffering and Li incorporation/adsorption, respectively. Fractionated heavy Li isotopes in water samples resulted from the formation of secondary solids which preferentially incorporated 6Li, with the separated clay-sized fraction of the regolith exhibiting more negative δ7Li values (-5.4 to −3.5 ‰) than the bulk regolith (∼-1.7 ‰). However, Li in secondary solids only accounted for 8 ± 6 % of the total Li hosted in bulk regolith, and consequently δ7Li in soil did not differ significantly from δ 7Li in bedrock. This is unexpected considering water is continuously removing 7Li in preference over 6Li from regolith. Mass balance calculations applied at the catchment scale point to an irreconcilable imbalance with our data. On one hand, the regolith’s δ7Li values are not negative enough to balance the 7Li export by river water, and on the other hand Li in the riverine dissolved load only accounts for ∼ 30 % of the Li solubilized from regolith. Therefore, we suggest that there might be a “hidden export pathway” for Li at our site, possibly subsurface removal of fine particles enriched in 6Li. In light of increasingly frequent observations of such isotopic imbalances in the Critical Zone this phenomenon deserves increased attention.
Table S5: Case 2 Full Results
Creators: name: Nandy, Debmalya
Publisher: name: figshare
Year: 2022
Subjects: subject: 70703 Veterinary Diagnosis and Diagnostics
subject: FOS: Veterinary sciences

description: Table S5: Medians (median absolute deviation in parentheses) of RF classification metrics (across 75 repetitions of random training/test splits), sensitivity (“Sens”), specificity (“Spec”), and total accuracy (“Tot Acc”), corresponding to Case 2 scenarios. Values closer to 1 indicate better performance. For post-ComBat lower bounds: 1) bold indicates significantly greater value (p-value < 0.05, Wilcoxon’s signed-rank paired one-sided test with continuity correction) compared to the corresponding pre-ComBat lower bound; 2) underline indicates corresponding upper bound is not significantly higher. Therefore, bold and underline together are the best results using ComBat.
A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways
Creators: name: Höper, Tessa
name: Karkossa, Isabel
name: Dumit, Verónica I.
name: Bergen, Martin Von
name: Schubert, Kristin
name: Haase, Andrea
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Allergic contact dermatitis
subject: Proteomics
subject: THP-1 cells
subject: Monocyte-derived dendritic cells
subject: SILAC
subject: LFQ
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Allergic contact dermatitis (ACD) is the predominant form of immunotoxicity in humans. The sensitizing potential of chemicals can be assessed in vitro. However, a better mechanistic understanding could improve the current OECD-validated test battery. The aim of this study was to get insights into toxicity mechanisms of four contact allergens, p-benzoquinone (BQ), 2,4-dinitrochlorobenzene (DNCB), p-nitrobenzyl bromide (NBB) and NiSO4, by analyzing differential proteome alterations in THP-1 cells using two common proteomics workflows, stable isotope labeling by amino acids in cell culture (SILAC) and label-free quantification (LFQ). Here, SILAC was found to deliver more robust results. Overall, the four allergens induced similar responses in THP-1 cells, which underwent profound metabolic reprogramming, including a striking upregulation of the TCA cycle accompanied by pronounced induction of the Nrf2 oxidative stress response pathway. The magnitude of induction varied between the allergens with DNCB and NBB being most potent. A considerable overlap between transcriptome-based signatures of the GARD assay and the proteins identified in our study was found. When comparing the results of this study to a previous proteomics study in human primary monocyte-derived dendritic cells, we found a rather low share in regulated proteins. However, on pathway level, the overlap was high, indicating that affected pathways rather than single proteins are more eligible to investigate proteomic changes induced by contact allergens. Overall, this study confirms the potential of proteomics to obtain a profound mechanistic understanding, which may help improving existing in vitro assays for skin sensitization.
ResearchBox 558, 'Study on Doxastic Voluntarism', https://researchbox.org/558
Creators: name: Lomholt, Rune Hejli
name: Nottelmann, Nikolaj
name: Booth, Anthony
Publisher: name: Zenodo
Year: 2022

description: Box title: 'Study on Doxastic Voluntarism'   Reference: Nottelmann N, Booth A, Lomholt R. (2022) 'Are We Pre-Theoretically Committed to Doxastic Voluntarism?'. Review of Philosophy and Psychology. . doi: 10.1007/s13164-022-00615-3Note: this backup was created automatically by a ResearchBox bot
Using Response Times for Joint Modeling of Careless Responding and Attentive Response Styles
Creators: name: Ulitzsch, Esther
name: Pohl, Steffi
name: Khorramdel, Lale
name: Kroehne, Ulf
name: Davier, Matthias Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: response bias
subject: careless responding
subject: response styles
subject: response times
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung

description: Questionnaires are by far the most common tool for measuring noncognitive constructs in psychology and educational sciences. Response bias may pose an additional source of variation between respondents that threatens validity of conclusions drawn from questionnaire data. We present a mixture modeling approach that leverages response time data from computer-administered questionnaires for the joint identification and modeling of two commonly encountered response bias that, so far, have only been modeled separately—careless and insufficient effort responding and response styles (RS) in attentive answering. Using empirical data from the Programme for International Student Assessment 2015 background questionnaire and the case of extreme RS as an example, we illustrate how the proposed approach supports gaining a more nuanced understanding of response behavior as well as how neglecting either type of response bias may impact conclusions on respondents’ content trait levels as well as on their displayed response behavior. We further contrast the proposed approach against a more heuristic two-step procedure that first eliminates presumed careless respondents from the data and subsequently applies model-based approaches accommodating RS. To investigate the trustworthiness of results obtained in the empirical application, we conduct a parameter recovery study.
Shear-wave velocity imaging of weathered granite in La Campana (Chile) from Bayesian inversion of micro-tremor H/V spectral ratios
Creators: name: Trichandi, Rahmantara
name: Bauer, Klaus
name: Ryberg, Trond
name: Wawerzinek, Britta
name: Vargas, Jaime Araya
name: Blanckenburg, Friedhelm Von
name: Krawczyk, Charlotte M.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: H/V spectral ratio
subject: Shear wave velocity
subject: Bayesian inversion
subject: Weathering zone
subject: Velocity gradient
subject: Bedrock detection
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Subsurface imaging of the regolith layer is an important tool for weathering zone characterization. For example, the extent of bedrock modification by weathering processes can be modelled by means of differing seismic velocities. We acquired a 360 m-long seismic profile in central Chile to characterise weathering at a semi-arid site. We used 87 3-component geophones, which continuously recorded ambient seismic noise for three days. The seismic line was centered at an 88 m deep borehole, providing core and downhole logging data for calibration. We extract Horizontal-to-Vertical Spectral Ratio (HVSR) curves along the seismic line to image the subsurface. Temporal analysis of the HVSR curves shows that the ambient noise vibrations recorded during the nighttime provide more stable HVSR curves. The trans-dimensional Bayesian Markov chain Monte Carlo (McMC) approach was used to invert the micro-tremor HVSR curves at each station to reconstruct 1D shear-wave velocity (Vs) models. The resulting individual 1D Vs models were merged to create a 2D Vs model along the linear seismic array in La Campana. The resulting Vs model shows an increase from 0.85 km/s at the surface to ca. 2.5 km/s at 100 m depth. We use the interface probability as a by-product of the Bayesian inversion to apply a more data-driven approach in identifying the different weathering layers. This method identified the boundary between saprolite and fractured bedrock at 42 m depth at the borehole, as evidenced by the interpretation of downhole logging data such as magnetic susceptibility. The resulting 2D Vs model of this site in Mediterranean climate shows a strong correlation between the interpreted weathering front at around 90-m depth and a higher precipitation rate in the study site compared to arid sites. The horizontal alignment of the weathering front indicates a correlation between the weathering front depth with topography and fractures in the bedrock.
Imbalances in Dissolved Elemental Export Fluxes Disclose “Hidden” Critical Zone Compartments
Creators: name: Uhlig, David
name: Sohrt, J.
name: Blanckenburg, Friedhelm Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: concentration - discharge relationship
subject: chemostasis
subject: solute fluxes
subject: dissolved export efficiency (DEE)
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: In streams, short-term element-specific solute fluxes are often not balanced with long-term chemical weathering fluxes determined in the residual solids from fractional element loss and denudation rate. The ratio of both estimates—the “Dissolved Export Efficiency” (DEE)—is frequently <1, indicating deficits in the stream dissolved load. To explore the cause of the stream deficits, we performed a daily water sampling campaign for one year in a forested headwater watershed in Southern Germany. We sampled surface runoff, above-canopy and below-canopy precipitation, subsurface flow from the organic soil layer, upper, and deep mineral soil, and groundwater. Regolith samples were obtained from a drill core and revealed the weathering front to lie between 7 and 15 m depth. We found a DEE < 1 for K, Si, Al, Fe. These elements are characterized by shallow slopes in C-Q relationships, and the imbalances were found to originate in the deep saprolite. Their export pathway potentially includes “hidden” Critical Zone compartments or fluxes, presumably unsampled colloids that are exported preferentially during rare flushing events with stochastic temporal distribution. The DEE of nutritive elements like Ca, Mg, and P is also <1. These elements are characterized by steeper C-Q slopes, and their imbalance can be explained by deep nutrient uptake followed by nutrient retainment in re-growing forest biomass or export in plant debris. The collective evidence for these imbalances, including previous evidence from metal stable isotopes, suggests that the deep Critical Zone represents the location for chemical or biogenic retention and release of solutes.
Precipitation Control on Weathering Intensity and Depositional Flux of Meteoric 10Be Revealed From Soil Profiles Along a Climate Gradient (Chile)
Creators: name: Krone, Laura V.
name: Wittmann, Hella
name: Blanckenburg, Friedhelm Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Meteoric 10Be
subject: Weathering Intensity
subject: Depositional Flux
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Along a climate gradient in the Chilean coastal mountains, we investigated denudation rates using the meteoric cosmogenic nuclide 10Be and its ratio to stable 9Be, and chemical depletion fractions (CDFs) in bulk soil samples. We find that the fraction of 9Be released from bedrock is a sensitive indicator of weathering, similar to CDF. Meteoric 10Be decreases exponentially with depth, reflecting the reactive nature of this tracer. We also measured denudation rates by the well-understood in situ cosmogenic 10Be system on quartz. Assuming that both systems record the same denudation rate we calculated the depositional flux of meteoric 10Be for each study site. The flux agrees to that derived from atmospheric models in the mediterranean and humid areas. In contrast, in the arid and semi-arid areas, the calculated flux agrees with a precipitation-derived flux, indicating delivery of 10Be to be affected by small-scale climatic variations not reflected by current atmospheric models.
ResearchBox 560, 'How Signals of Status Undermine Cooperation', https://researchbox.org/560
Creators: name: Shalena Srna
name: Alixandra Barasch
name: Deborah Small
Publisher: name: Zenodo
Year: 2022

description: Box title: 'How Signals of Status Undermine Cooperation'   Reference: Shalena Srna; Alixandra Barasch; Deborah A. Small, 'On the Value of Modesty: How Signals of Status Undermine Cooperation', Journal of Personality and Social Psychologyhttps://doi.org/10.1037/pspa0000303Note: this backup was created automatically by a ResearchBox bot
International franchise expansion: The role of institutions and transaction costs
Creators: name: Hoffman, Richard C.
name: Munemo, Jonathan
name: Watson, Sharon
Publisher: name: Maryland Shared Open Access Repository
Year: 2016
Subjects: Intentional expansion
Franchise companies
Institutional theory

description: In this study, we examine how a country’s institutional environment affects the international expansion activities of U.S. franchise companies. We draw on institutional and transaction cost theories to develop a model and a set of hypotheses regarding the effect of political, regulatory and infrastructural institutions, as well as economic instability, on international franchise expansion. Using a sample of U.S. franchise firms and data from a combination of secondary sources, we test these hypotheses by estimating a panel regression model. Our results demonstrate for the first time that, in addition to favorable political governance, a country’s business climate, including entry regulations, taxes, and communications infrastructure, is an important predictor of foreign franchise firms’ expansion into that country. Implications for practice and future research also are discussed.
Interspecific differences in swimming performance, behavior and survival between native Italian gudgeon (Gobio benacensis Pollini, 1816) and non-native European gudgeon (Gobio gobio Linnaeus, 1758)
Creators: name: Nyqvist, D.
name: Schiavon, Alfredo
name: Candiotto, Alfredo
name: Comoglio, C.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Invasive species
subject: maximum swimming speed
subject: activity
subject: freezing
subject: boldness
subject: mortality
subject: 500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::590 Tiere (Zoologie)

description: Introduction of non-native species is an important cause of biodiversity decline in rivers. Separated by mountains and salt water, the freshwater fish fauna in Italy has experienced a natural isolation from fish in continental Europe. As a consequence, several Italian fish species have diverged from their European sister species, likely with unique adaptations to the local environment. Relatedly, the region is also susceptible to the invasion of non-native fish, and today almost half the fish species present are of non-native origin. Several of these non-native species have Italian congeners susceptible to competition and hybridizations, and, in the long run, displacements and extinctions. One such example is the Italian gudgeon (Gobio benacensis) and its European congener European gudgeon (Gobio gobio). During the last few decades the European gudgeon was introduced in Italian waters and has since spread rapidly, causing progressive declines in the Italian species. As for several other similar species pairs, little is known about potential differences in ecology and behavior. Here we study differences between Italian and European gudgeons in a controlled laboratory environment, using a combined open field and provoked escape response test, as well as tracking their sympatric survival over time in the hatchery. The smaller Italian gudgeon displayed a lower maximum swimming speed compared to the larger European gudgeon. The Italian gudgeon also experienced substantially higher sympatric mortality, resulting in only European gudgeon surviving to the end of the experiment. Contrary to expectations, no difference was seen in boldness and the Italian gudgeon displayed a higher movement activity, moving a larger distance in an open field test, compared to its European sister species. The reported differences could play a role in the replacement process, and may also have impacts on the surrounding ecosystem, and the prey and predators that have coevolved with the Italian species.
title: Sex Work, Sensibility, and Virtue
title: Isabelle de Charrière’s Response to Rousseau
titleType: Subtitle
Creators: name: Stacey, Jessica
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: sensibility
subject: prostitution in fiction
subject: moral hygiene in fiction
subject: eighteenth-century women's writing
subject: 800 Literature::840 Literatures of Romance languages::843 French fiction

description: In Julie (1761), Jean-Jacques Rousseau changed courtesan Laure’s projected happy matrimonial ending and cut most of her story, consigning her to a convent and to the narrative’s margins. Why was the former sex worker judged, despite her virtue and sensibility, an element inassimilable to the virtuous environment of Clarens? Conversely, Isabelle de Charrière, a dedicated reader of Rousseau, makes courtesan Caliste the main character of a novella. Caliste, too, is denied a happy ending, yet repeatedly and convincingly she makes the case that she is not only virtuous but also (like Julie) able to craft an environment conducive to virtue—against those who argue that lost sexual honour renders a woman toxic. Rousseau’s reworked depiction of Laure, this article argues, is best understood with reference to his philosophy of sensation, hygiene, and ethics: la morale sensitive. Although Charrière never names this philosophy, her Caliste develops and challenges it.
Increasing vaccinations through an on‐site school‐based education and vaccination program: A city‐wide cluster randomized controlled trial
Creators: name: Bethke, Norma
name: O'Sullivan, Julie L.
name: Keller, Jan
name: Bernuth, Horst Von
name: Gellert, Paul
name: Seybold, Joachim
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: educational
subject: measles
subject: school‐based
subject: self‐efficacy
subject: theory‐based
subject: vaccination
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::614 Inzidenz und Prävention von Krankheiten

description: Vaccination rates for mumps, measles, and rubella (MMR) and tetanus, diphtheria, pertussis, and polio (Tdap‐IPV) fall short of global targets, highlighting the need for vaccination interventions. This study examines the effectiveness of a city‐wide school‐based educational vaccination intervention as part of an on‐site vaccination program aimed at increasing MMR and Tdap‐IPV vaccination rates versus on‐site vaccination alone among sociodemographically diverse students from Berlin, Germany. The study was a 1:1 two‐arm cluster randomized controlled trial, with schools randomly assigned to either the Educational Class Condition (ECC) or the Low‐Intensity Information Condition (LIIC). Both received an on‐site vaccination program, while students in the ECC received an additional educational unit. Primary outcomes were MMR and Tdap‐IPV vaccination rates. In total, 6512 students from 25 randomly selected urban area secondary schools participated. For students providing their vaccination documents on the day of the intervention (2273, 34.9%), adjusted Poisson mixed models revealed significant between‐group differences in favor of the ECC (MMR: logRR = 0.47, 95%CI [0.01,0.92], RR = 1.59; Tdap‐IPV: logRR = 0.28, 95%CI [0.10,0.47], RR = 1.32). When adjusting for socioeconomic and migration background, between‐group differences became non‐significant for MMR but remained significant for Tdap‐IPV. Findings suggest that educational, school‐based on‐site vaccination appears to be a promising strategy for increasing vaccination uptake in adolescents.
DIGITAL TRANSFORMATION OF BUSINESS MODELS OF PROVIDING LOGISTICS SERVICES TO CUSTOMERS
Creators: name: O.M.Rajabov, Samarkand Institute of Economics and Service is an independent researcher
Publisher: name: Zenodo
Year: 2024

description: High-quality service is the basis of successful business in the 21st century. Even in production, only half of the success of economic activity is the production of high-quality advanced products. The other half is hard to imagine without knowing how to sell and high-quality service. Any product developer should be able to arouse customer interest in his product. High-level sales and service play an important role in this.
Proteomic analysis of extracellular vesicles derived from canine mammary tumour cell lines identifies protein signatures specific for disease state
Creators: name: Gutierrez-Riquelme, Tania
name: Karkossa, Isabel
name: Schubert, Kristin
name: Liebscher, Gudrun
name: Packeiser, Eva-Maria
name: Nolte, Ingo
name: Bergen, Martin Von
name: Murua Escobar, Hugo
name: Aguilera-Rojas, Matias
name: Einspanier, Ralf
name: Stein, Torsten
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Canine mammary tumour
subject: Cell culture
subject: Extracellular vesicles
subject: Proteomics
subject: Size exclusion chromatography
subject: WGCNA
subject: Biglycan
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Background Canine mammary tumours (CMT) are among the most common types of tumours in female dogs. Diagnosis currently requires invasive tissue biopsies and histological analysis. Tumour cells shed extracellular vesicles (EVs) containing RNAs and proteins with potential for liquid biopsy diagnostics. We aimed to identify CMT subtype-specific proteome profiles by comparing the proteomes of EVs isolated from epithelial cell lines derived from morphologically normal canine mammary tissue, adenomas, and carcinomas. Methods Whole-cell protein lysates (WCLs) and EV-lysates were obtained from five canine mammary cell lines: MTH53A (non-neoplastic); ZMTH3 (adenoma); MTH52C (simple carcinoma); 1305, DT1406TB (complex carcinoma); and their proteins identified by LC-MS/MS analyses. Gene Ontology analysis was performed on differentially abundant proteins from each group to identify up- and down-regulated biological processes. To establish CMT subtype-specific proteomic profiles, weighted gene correlation network analysis (WGCNA) was carried out. Results WCL and EVs displayed distinct protein abundance signatures while still showing the same increase in adhesion, migration, and motility-related proteins in carcinoma-derived cell lines, and of RNA processing and RNA splicing factors in the adenoma cell line. WGCNA identified CMT stage-specific co-abundant EV proteins, allowing the identification of adenoma and carcinoma EV signatures not seen in WCLs. Conclusions EVs from CMT cell lines exhibit distinct protein profiles reflecting malignancy state, allowing us to identify potential biomarkers for canine mammary carcinomas, such as biglycan. Our dataset could therefore potentially serve as a basis for the development of a less invasive clinical diagnostic tool for the characterisation of CMT.
The impact of leaving group anomericity on the structure of glycosyl cations of protected galactosides
Creators: name: Greis, Kim
name: Lettow, Maike
name: Kirschbaum, Carla
name: Moon, Sooyeon
name: Pardo‐Vargas, Alonso
name: Seeberger, Peter H.
name: Pagel, Kevin
name: Mucha, Eike
name: Thomas, Daniel A.
name: Helden, Gert Von
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: anomeric memory
subject: IR spectroscopy
subject: glycosylation
subject: mass spectrometry
subject: glycosyl cations
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie

description: It has been reported that fragments produced by glycosidic bond breakage in mass spectrometry‐based experiments can retain a memory of their anomeric configuration, which has major implications for glycan sequencing. Herein, we use cryogenic vibrational spectroscopy and ion mobility‐mass spectrometry to study the structure of B‐type fragments of protected galactosides. Cationic fragments were generated from glycosyl donors carrying trichloroacetimidate or thioethyl leaving groups of different anomeric configuration. The obtained infrared signatures indicate that the investigated fragments exhibit an identical structure, which suggests that there is no anomeric memory in B‐type ions of fully protected monosaccharides.
Supplementary document for 36 Hz integral linewidth laser based on a photonic integrated 4.0-meter coil resonator - 5880593.pdf
Creators: name: Blumenthal, Daniel
name: LIU, KAIKAI
name: Chauhan, Nitesh
name: Wang, Jiawei
name: Isichenko, Andrei
name: Brodnik, Grant
name: Morton, Paul
name: Behunin, Ryan
name: Papp, Scott
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Non-Redlined