title: Ð§Ð¸ÑÐ»ÐµÐ½Ð½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ° Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸Ñ Ð¿Ð¾Ð´ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ Ð³Ð¸Ð´ÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¸Ð» Ð¸ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Numerical simulation of directional transport of microparticles under the influence of hydrodynamic forces and electric field
Creators: name: Ð¢ÐµÑÐµÑÐµÐ½ÐºÐ¾Ð²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐ¹ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑ
ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÐ¹ ÑÐ¾ÑÑÐ´
ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð¾Ð»Ðµ
ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ
Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ðµ ÑÐ°ÑÑÐ¸Ñ
Comsol Multiphysics
targeted delivery
blood vessel
electric field
numerical model
particle deposition

description: ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â Ð°Ð´ÑÐµÑÐ½Ð°Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ° Ð»ÐµÐºÐ°ÑÑÑÐ² Ð² ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ Ð¿Ð¾Ð´ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ Ð³Ð¸Ð´ÑÐ°Ð²Ð»Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¸Ð» Ð¸ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ñ. Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ â ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ° Ð·Ð°ÑÑÐ¶ÐµÐ½Ð½ÑÑ ÑÐ°ÑÑÐ¸Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð°, Ð²Ð²ÐµÐ´ÐµÐ½Ð½ÑÑ Ð² ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÑÐµÐ¼ÑÐ¼Ð¸ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾Ð»ÐµÐ¼, Ð¸ Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸ÑÑ Ð¸Ñ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ðµ Ð½Ð° ÑÑÐµÐ½ÐºÑ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ´Ð°. ÐÐ»Ñ ÑÐ°ÑÑÐµÑÐ¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¾ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾-Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ COMSOL Multiphysics. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð° ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð°Ñ 3D-Ð¼Ð¾Ð´ÐµÐ»Ñ Ð¼Ð°ÑÑÐ¾Ð¿ÐµÑÐµÐ½Ð¾ÑÐ° Ð´Ð¸ÑÐºÑÐµÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾ÐºÐ° ÑÐ¼ÐµÑÐ¸ ÑÐ°ÑÑÐ¸Ñ Ñ ÑÐ°Ð·Ð½ÑÐ¼Ð¸ Ð·Ð°ÑÑÐ´Ð°Ð¼Ð¸, Ð¸Ð¼Ð¸ÑÐ¸ÑÑÑÑÐ¸Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÐ¹ Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ. ÐÐ±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð¸ÑÐºÐ»ÑÑÐµÐ½Ð¸Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¾Ð½Ð½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð² Ð¸Ð·-Ð·Ð° Ð¸Ñ Ð¼Ð°Ð»Ð¾ÑÑÐ¸. Ð£ÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÑ ÑÑÐµÑÐ° Ð±ÑÐ»Ð° Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð° Ð´Ð»Ñ ÑÐ°Ð·Ð½ÑÑ ÑÐ°ÑÑÐµÑÐ½ÑÑ ÑÐµÑÐ¾Ðº. Ð­ÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ² ÑÐ¾ÑÑÐ°Ð²Ð»ÑÐµÑ 70-80 Ð¿ÑÐ¾ÑÐµÐ½ÑÐ¾Ð², ÑÑÐ¾ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¸ÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ°. ÐÐ±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð½Ð°Ð»Ð¸ÑÐ¸Ðµ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² Ð´Ð»Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ¾Ð² Ð¼Ð½Ð¾Ð³Ð¾ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ½Ð¾Ð¹ ÑÐ¼ÐµÑÐ¸, ÑÑÐ¾ Ð² Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ðµ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ñ Ð¿Ð¾Ð´Ð±Ð¸ÑÐ°ÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´ÑÑÐ¸Ðµ ÑÑÐ»Ð¾Ð²Ð¸Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ð¾Ð¹ Ð´Ð»Ñ ÐºÐ°Ð¶Ð´Ð¾Ð³Ð¾ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ»ÑÑÐ°Ñ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐ±Ð»Ð¸ÐºÐ¾Ð²Ð°Ð½Ñ Ð² ÑÐµÐ·Ð¸ÑÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ð¹ Â«ÐÐµÐ´ÐµÐ»Ñ Ð½Ð°ÑÐºÐ¸ ÐÐ­ÐÐ¢ 2023Â» (20â25 Ð½Ð¾ÑÐ±ÑÑ 2023 Ð³Ð¾Ð´Ð°), XII ÐÑÐµÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ ÐÐ°ÑÑÐ½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ð¸ Ñ Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÐ¼ ÑÑÐ°ÑÑÐ¸ÐµÐ¼ Â«ÐÐ°ÑÐºÐ° Ð½Ð°ÑÑÐ¾ÑÑÐµÐ³Ð¾ Ð¸ Ð±ÑÐ´ÑÑÐµÐ³Ð¾Â» (16â17(18) Ð¼Ð°Ñ 2024),Â  Ð¸ Ð²ÐºÐ»ÑÑÐµÐ½Ñ Ð² Ð¾ÑÑÐµÑ ÐÐ°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð¼ÐµÑÐ¸ÑÐµÐ»ÑÐ½ÑÑ Ð±Ð¸Ð¾- Ð¸ ÑÐµÐ¼Ð¾ÑÐµÐ½ÑÐ¾ÑÐ½ÑÑ Ð¼Ð¸ÐºÑÐ¾ÑÐ¸ÑÑÐµÐ¼ ÐÐ½ÑÑÐ¸ÑÑÑÐ° Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¸Ð±Ð¾ÑÐ¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð ÐÐ.
description: The object of the study is targeted drug delivery in the blood system under the action of hydraulic and electric field forces. The aim of the work is development of a model of directed transport of charged drug particles injected into the circulatory system and controlled by electric field, and to provide their deposition on the wall of the blood vessel. Specialized software and mathematical software COMSOL Multiphysics was used for computations. As a result of the study, a numerical 3D model of mass transfer for the flow of a discrete particles mixture with different charges mimicking a drug was constructed. The ability to exclude diffusion effects due to their negligibility was substantiated. The stability of the computation was confirmed for different meshes. The efficiency of this drug delivery model is 70-80 percent, which corresponds to the results of similar studies of targeted delivery. The existence of optimal modes for different components of the multicomponent particles mixture was found, which in the future will allow selecting the appropriate system control conditions for individual clinical cases. The results of the study were published in the abstracts of the conferences âIEIT Science Week 2023â (November 20-25, 2023), XII International Conference âScience: the Present and Futureâ (May 16-17(18), 2024), and included in the report of the Laboratory of Information-Measuring Bio- and Chemosensor Microsystems of the Institute of Analytical Instrumentation.