cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phase sensitivity bounds for two-mode interferometers
Creators: name: Pezzè, Luca
name: Hyllus, Philipp
name: Smerzi, Augusto
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We provide general bounds of phase estimation sensitivity in linear two-mode interferometers. We consider probe states with a fluctuating total number of particles. With incoherent mixtures of state with different total number of particles, particle entanglement is necessary but not sufficient to overcome the shot noise limit. The highest possible phase estimation sensitivity, the Heisenberg limit, is established under general unbiased properties of the estimator. When coherences can be created, manipulated and detected, a phase sensitivity bound can only be set in the central limit, with a sufficiently large repetition of the interferometric measurement.
description: comments and remarks are welcome
Generation of Lung Adenocarcinoma DNA Aptamers for Cancer Studies
Creators: name: Chen, Hui William
name: López-Colón, Dalia
name: Sefah, Kwame
name: Tan, Weihong
name: Jiménez, Elizabeth
name: Van Simaeys, Dimitri
name: Tockman, Melvyn S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Lung cancer is the most lethal malignancy in the world, and each year thousands of people die from this disease. Early detection has proven to increase the 5-year survival for this cancer in general, independent of the origination site in the lung. To address this challenge, we have used cell-based SELEX (Systematic Evolution of Ligands by Exponential Enrichment) to select a panel of aptamers capable of distinguishing lung adenocarcinoma cells from normal lung epithelial cells. These aptamers bind at physiological and formalin-fixed conditions and display affinity for their targets with apparent Kd's in the nanomolar range. Our findings suggest that the selected aptamers have the potential to be used in clinical settings, as well as to improve classification of nonsurgical specimens, another current challenge in lung cancer.
BUXORO TURISTIK DESTINATSIYASI IJTIMOIY MEDIA TARG'IBOTIDA KONTENT TURINING BO'LINISHI
Creators: name: Xalimova, Nigina
Publisher: name: Zenodo
Year: 2024

description: Ijtimoiy media orqali e’lon qilinadigan kontent umumiy ko‘rinishda besh turda bo‘ladi. Buxoro turistik destinatsiyasining ijtimoiy mediadagi faoliyatining kontent turida bir qancha o‘zgarishlar paydo bo‘ladi. Turistik destinatsiya shaxs yoki korxona bo‘lmaganligi uchun, uning shaxsiyati mavjud bo‘lmaydi, ya’ni, shaxsiy (axborot ko‘rinishidagi) kontent turining foiz ko‘rsatkichlari promo (brend) kontent turiga qo‘shiladi va natijada ushbu turdagi kontentda turistik brend targ‘ib qilinadi. Masalan, destinatsiya to‘g‘risidagi video lavhalar, rasmlar to‘plami va boshqalar. Ushbu kontent taqsimotini quyidagi chizmada ko‘rish mumkin:
A dissipative force between colliding viscoelastic bodies: Rigorous approach
Creators: name: Brilliantov, Nikolay V.
name: Pimenova, Anastasiya V.
name: Goldobin, Denis S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A collision of viscoelastic bodies is analysed within a mathematically rigorous approach. We develop a perturbation scheme to solve continuum mechanics equation, which deals simultaneously with strain and strain rate in the bulk of the bodies' material. We derive dissipative force that acts between particles and express it in terms of particles' deformation, deformation rate and material parameters. It differs noticeably from the currently used dissipative force, found within the quasi-static approximation and does not suffer from inconsistencies of this approximation. The proposed approach may be used for other continuum mechanics problems where the bulk dissipation is addressed.
description: 6 pages, 1 figure
Fannie Mae National Housing Survey Monthly Key Indicators--June, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Fannie Mae National Housing Survey Monthly Key Indicators--July, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Penrose Tilings as Jammed Solids
Creators: name: Stenull, Olaf
name: Lubensky, T. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Penrose tilings form lattices, exhibiting 5-fold symmetry and isotropic elasticity, with inhomogeneous coordination much like that of the force networks in jammed systems. Under periodic boundary conditions, their average coordination is exactly four. We study the elastic and vibrational properties of rational approximants to these lattices as a function of unit-cell size $N_S$ and find that they have of order $\sqrt{N_S}$ zero modes and states of self stress and yet all their elastic moduli vanish. In their generic form obtained by randomizing site positions, their elastic and vibrational properties are similar to those of particulate systems at jamming with a nonzero bulk modulus, vanishing shear modulus, and a flat density of states.
description: 5 pages, 4 figures
Molecular interplay of ADAMTS13-MDTCS and von willebrand Factor-A2: deepened insights from extensive atomistic simulations
Creators: name: Geist, Norman
name: Nagel, Felix
name: Delcea, Mihaela
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Medicine
Cell Biology
Biological Sciences not elsewhere classified
Computational Biology

description: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening disease. One hallmark is severe ADAMTS13 deficiency, causing ultra-large von Willebrand factor (VWF) multimers to accumulate, leading to microthrombi and lastly to microangiopathic hemolytic anemia and severe thrombocytopenia. Despite great success in recent decades, the molecular picture of the interaction between VWF and ADAMTS13 remains vague. Here, we utilized modern replica-exchange molecular dynamics simulations with the TIGER2h method to sample a vast configurational space of the isolated ADAMTS13-MDTCS domains and the exposure to its substrate and activating cofactor – the unraveled VWF-A2 domain. The sampling of binding sites and conformations was guided and filtered in agreement with available experimental evidence. We provide comprehensive information on exosites for each domain and direct pairs of interacting amino acids, for the first time. The major binding cluster for the active site of the MP domain contrasts the previous mapping of VWF-A2 residues and reciprocal binding pockets. Two major binding modes are revealed and provide access to conformational changes of an extended gatekeeper tetrad upon overcoming local latency during substrate binding and to a dedicated recruitment mechanism. Our work adds the first molecular interaction model that places previous experimental results in perspective to better understand disease-related mutations towards improved therapies. Numerous empirical targets are proposed to verify the given binding modes, to refine the overall picture of MP binding pockets, the role of Dis binding in MP activation and the passage of the Cys-rich domain through VWF-A2, thus deepening the understanding of a highly dynamic interplay. Communicated by Ramaswamy H. Sarma
Fannie Mae National Housing Survey Monthly Key Indicators-August, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Quantum chaos in supersymmetric Yang-Mills-like model: equation of state, entanglement, and spectral form-factors
Creators: name: Buividovich, Pavel
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze in detail a sharp transition between the low-energy, low-dimensional eigenstates and the high-energy chaotic bulk of the spectrum for a simple supersymmetric quantum-mechanical model with Hamiltonian $\hat{H}_S = \left(\hat{p}_1^2 + \hat{p}_2^2 + \hat{x}_1^2 \, \hat{x}_2^2 \right) \otimes I + \hat{x}_1 \otimes σ_1 + \hat{x}_2 \otimes σ_3$, which mimics the structure of the Banks-Fischler-Susskind-Stanford (BFSS) matrix model, the spatially compactified $\mathcal{N} = 1$ super-Yang-Mills theory. We conjecture that this transition might be similar to the transition between the $D0$-brane and $M$-theory regimes in the BFSS model, and find that it does not lead to irregularities in the thermodynamic equation of state. We demonstrate that real-time spectral form-factor for our supersymmetric model exhibits the ``ramp'' behavior typical for quantum chaos. We also analyze the entanglement entropy and the spectrum of the reduced density matrix of the eigenstates of $\hat{H}_S$, considering one of the bosonic degrees of freedom as a subsystem. The entanglement entropy of low-energy eigenstates appears to be practically energy-independent. Exactly at the onset of random-matrix-type level spacing fluctuations, this behavior rapidly changes into a steady growth of entanglement with energy. We demonstrate that the spectrum of the reduced density matrix also exhibits universal level-spacing fluctuations towards its higher end, even for the ground state of the supersymmetric model. Thus even the regularly spaced, non-chaotic eigenstates contain some information about semi-classical chaotic dynamics at high energies.
description: Proceedings of the 39th International Symposium on Lattice Field Theory (Lattice 2022), 8-12 August 2022, Bonn, Germany. v2: updated references, published version. 17 pages, 6 figures, PoS style
Two years of ALMA bibliography - lessons learned
Creators: name: Meakins, Silvia
name: Grothkopf, Uta
name: Bishop, Marsha J.
name: Stoehr, Felix
name: Tatematsu, Ken
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Digital Libraries (cs.DL)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Telescope bibliographies are integral parts of observing facilities. They are used to associate the published literature with archived observational data, to measure an observatory's scientific output through publication and citation statistics, and to define guidelines for future observing strategies. The ESO and NRAO librarians as well as NAOJ jointly maintain the ALMA (Atacama Large Millimeter/submillimeter Array) bibliography, a database of refereed papers that use ALMA data. In this paper, we illustrate how relevant articles are identified, which procedures are used to tag entries in the database and link them to the correct observations, and how results are communicated to ALMA stakeholders and the wider community. Efforts made to streamline the process will be explained and evaluated, and a first analysis of ALMA papers published after two years of observations will be given.
description: 7 pages; to be published in the Proceedings of SPIE, vol. 9149, 9149-81 (2014)
Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation
Creators: name: Pérez-Otaño, Isabel
name: Lipton, Stuart A.
name: Henson, Maile A.
name: Nakanishi, Nobuki
name: Lawson, Shelikha N.
name: Larsen, Rylan S.
name: Philpot, Benjamin D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Glutamatergic synapse maturation is critically dependent upon activation of NMDA-type glutamate receptors (NMDARs); however, the contributions of NR3A subunit-containing NMDARs to this process have only begun to be considered. Here we characterized the expression of NR3A in the developing mouse forebrain and examined the consequences of NR3A deletion on excitatory synapse maturation. We found that NR3A is expressed in many subcellular compartments, and during early development, NR3A subunits are particularly concentrated in the postsynaptic density (PSD). NR3A levels dramatically decline with age and are no longer enriched at PSDs in juveniles and adults. Genetic deletion of NR3A accelerates glutamatergic synaptic transmission, as measured by AMPAR-mediated postsynaptic currents recorded in hippocampal CA1. Consistent with the functional observations, we observed that the deletion of NR3A accelerated the expression of the glutamate receptor subunits NR1, NR2A, and GluR1 in the PSD in postnatal day (P) 8 mice. These data support the idea that glutamate receptors concentrate at synapses earlier in NR3A-knockout (NR3A-KO) mice. The precocious maturation of both AMPAR function and glutamate receptor expression are transient in NR3A-KO mice, as AMPAR currents and glutamate receptor protein levels are similar in NR3A-KO and wildtype mice by P16, an age when endogenous NR3A levels are normally declining. Taken together, our data support a model whereby NR3A negatively regulates the developmental stabilization of glutamate receptors involved in excitatory neurotransmission, synaptogenesis, and spine growth.
Fannie Mae National Housing Survey Monthly Key Indicators-September, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, NNK and NNN
Creators: name: Thasweer, A. M.
name: Devi, P. Renuka
name: Thirunavukkarasu, Velusamy
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Smoking constitutes a major global health problem. As it triggers various health hazards including cancers, cardiac and pulmonary illness, it is imperative to understand the mechanism of action of various smoke constituents on our cellular processes. Various in vitro studies have compiled the affinity of cigarette smoke constituents on various nicotinic acetylcholine receptors (nAChRs). But the nature of the intermolecular interactions contributing to this affinity and the key amino acids in the receptor active sites involved in this are not investigated so far. Here, we are examining the interaction of α7nAChR and α4β2nAChR on nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosornicotine (NNN), the physiologically significant constituents in smoke, through molecular docking and dynamics simulations study. The docking of α4β2nAChR structure with the ligands nicotine, NNK and NNN yielded docking scores of −41.45 kcal/mol, −59.28 kcal/mol and −54.60 kcal/mol, respectively, and that of α7nAChR receptor molecule with the ligands yielded docking scores of −59.54 kcal/mol, −71.06 kcal/mol and −70.86 kcal/mol, respectively. The study showed that NNK exhibited the highest affinity with the ligands which was confirmed by dynamics simulation. But higher stability of interactions as surmised from Molecular dynamics simulations was found for nicotine with α4β2nAChR and NNN with α7nAChR. The findings validate the in vitro studies comparing the affinities of these compounds. The study will be useful in formulating effective nAChR agonists to treat neurological disorders and antagonists for smoke deaddiction and improve health standards. Communicated by Ramaswamy H. Sarma
Genetic Dissection of the Canq1 Locus Governing Variation in Extent of the Collateral Circulation
Creators: name: Zhang, Hua
name: Wang, Shiliang
name: Sealock, Robert
name: Faber, James E.
name: Wiltshire, Tim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundNative (pre-existing) collaterals are arteriole-to-arteriole anastomoses that interconnect adjacent arterial trees and serve as endogenous bypass vessels that limit tissue injury in ischemic stroke, myocardial infarction, coronary and peripheral artery disease. Their extent (number and diameter) varies widely among mouse strains and healthy humans. We previously identified a major quantitative trait locus on chromosome 7 (Canq1, LOD = 29) responsible for 37% of the heritable variation in collateral extent between C57BL/6 and BALB/c mice. We sought to identify candidate genes in Canq1 responsible for collateral variation in the cerebral pial circulation, a tissue whose strain-dependent variation is shared by similar variation in other tissues.Methods and FindingsCollateral extent was intermediate in a recombinant inbred line that splits Canq1 between the C57BL/6 and BALB/c strains. Phenotyping and SNP-mapping of an expanded panel of twenty-one informative inbred strains narrowed the Canq1 locus, and genome-wide linkage analysis of a SWRxSJL-F2 cross confirmed its haplotype structure. Collateral extent, infarct volume after cerebral artery occlusion, bleeding time, and re-bleeding time did not differ in knockout mice for two vascular-related genes located in Canq1, IL4ra and Itgal. Transcript abundance of 6 out of 116 genes within the 95% confidence interval of Canq1 were differentially expressed >2-fold (p-value<0.05÷150) in the cortical pia mater from C57BL/6 and BALB/c embryos at E14.5, E16.5 and E18.5 time-points that span the period of collateral formation.ConclusionsThese findings refine the Canq1 locus and identify several genes as high-priority candidates important in specifying native collateral formation and its wide variation.
How structurally stable are global socioeconomic systems?
Creators: name: Saavedra, Serguei
name: Rohr, Rudolf P.
name: Gilarranz, Luis J.
name: Bascompte, Jordi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Populations and Evolution (q-bio.PE)
subject: General Finance (q-fin.GN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences
subject: FOS: Economics and business

description: The stability analysis of socioeconomic systems has been centered on answering whether small perturbations when a system is in a given quantitative state will push the system permanently to a different quantitative state. However, typically the quantitative state of socioeconomic systems is subject to constant change. Therefore, a key stability question that has been under-investigated is how strong the conditions of a system itself can change before the system moves to a qualitatively different behavior, i.e., how structurally stable the systems is. Here, we introduce a framework to investigate the structural stability of socioeconomic systems formed by the network of interactions among agents competing for resources. We measure the structural stability of the system as the range of conditions in the distribution and availability of resources compatible with the qualitative behavior in which all the constituent agents can be self-sustained across time. To illustrate our framework, we study an empirical representation of the global socioeconomic system formed by countries sharing and competing for multinational companies used as proxy for resources. We demonstrate that the structural stability of the system is inversely associated with the level of competition and the level of heterogeneity in the distribution of resources. Importantly, we show that the qualitative behavior of the observed global socioeconomic system is highly sensitive to changes in the distribution of resources. We believe this work provides a methodological basis to develop sustainable strategies for socioeconomic systems subject to constantly changing conditions.
Fannie Mae National Housing Survey Monthly Key Indicators-October, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene developed under an international agreement with Sweden
Creators: name: Mattie, D.R.
name: Wong, B.A.
name: Mumy, K.L.
name: McInturf, S.M.
name: Shafer, L.M.
name: Allen, R.
name: Edwards, J.T.
name: Sibomana, I.
name: Sterner, T.R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Alcohol-to-jet (ATJ) Synthetic Kerosene with Aromatics (SKA) fuels are produced by dehydration and refining of alcohol feed stocks. ATJ SKA fuel known as SB-8 was developed by Swedish Biofuels as a cooperative agreement between Sweden and AFRL/RQTF. SB-8 including standard additives was tested in a 90-day toxicity study with male and female Fischer 344 rats exposed to 0, 200, 700, or 2000 mg/m3 fuel in an aerosol/vapor mixture for 6 hr/day, 5 days/week. Aerosols represented 0.04 and 0.84% average fuel concentration in 700 or 2000 mg/m3 exposure groups. Examination of vaginal cytology and sperm parameters found no marked changes in reproductive health. Neurobehavioral effects were increased rearing activity (motor activity) and significantly decreased grooming (functional observational battery) in 2000 mg/m3 female rats. Hematological changes were limited to elevated platelet counts in 2000 mg/m3 exposed males. Minimal focal alveolar epithelial hyperplasia with increased number of alveolar macrophages was noted in some 2000 mg/m3 males and one female rat. Additional rats tested for genotoxicity by micronucleus (MN) formation did not detect bone marrow cell toxicity or alterations in number of MN; SB-8 was not clastogenic. Inhalation results were similar to effects reported for JP-8. Both JP-8 and SB fuels were moderately irritating under occlusive wrapped conditions but slightly irritating under semi-occlusion. Exposure to SB-8, alone or as 50:50 blend with petroleum-derived JP-8, is not likely to enhance adverse human health risks in the military workplace.
A Survey of the Molecular ISM Properties of Nearby Galaxies using the Herschel FTS
Creators: name: Kamenetzky, J.
name: Rangwala, N.
name: Glenn, J.
name: Maloney, P. R.
name: Conley, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The 12CO J=4-3 to J=13-12 lines of the interstellar medium from nearby galaxies, newly observable with the Herschel SPIRE Fourier Transform Spectrometer (FTS), offer an opportunity to study warmer, more luminous molecular gas than that traced by 12CO J=1-0. Here we present a survey of 17 nearby infrared-luminous galaxy systems (21 pointings). In addition to photometric modeling of dust, we modeled full 12CO spectral line energy distributions from J=1-0 to J=13-12 with two components of warm and cool CO gas, and included LTE analysis of [CI], [CII], [NII] and H2 lines. CO is emitted from a low-pressure/high-mass component traced by the low-J lines and a high-pressure/low-mass component which dominates the luminosity. We found that, on average, the ratios of the warm/cool pressure, mass, and 12CO luminosity are 60 +/- 30, 0.11 +/- 0.02, and 15.6 +/- 2.7. The gas-to-dust-mass ratios are < 120 throughout the sample. The 12CO luminosity is dominated by the high-J lines and is 4 $\times 10^{-4}$ LFIR on average. We discuss systematic effects of single-component and multi-component CO modeling (e.g., single-component J < 3 models overestimate gas pressure by ~ 0.5 dex), as well as compare to Galactic star-forming regions. With this comparison, we show the molecular interstellar medium of starburst galaxies is not simply an ensemble of Galactic-type GMCs. The warm gas emission is likely dominated by regions resembling the warm extended cloud of Sgr B2.
description: Accepted by ApJ
Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels
Creators: name: Hesker, Pamela R.
name: Nguyen, MyTrang
name: Koller, Beverly H.
name: Ting, Jenny P.-Y.
name: Kovarova, Martina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encodes the protein pyrin/TRIM20/Marenostrin. The mechanism by which mutations in pyrin alter protein function to cause episodic inflammation is controversial. To address this question, we have generated a mouse line lacking the Mefv gene by removing a 21 kb fragment containing the entire Mefv locus. While the development of immune cell populations appears normal in these animals, we show enhanced interleukin (IL) 1β release by Mefv−/− macrophages in response to a spectrum of inflammatory stimuli, including stimuli dependent on IL-1β processing by the NLRP1b, NLRP3 and NLRC4 inflammasomes. Caspase-1 activity, however, did not change under identical conditions. These results are consistent with a model in which pyrin acts to limit the release of IL-1β generated by activation and assembly of inflammasomes in response to subclinical immune challenges.
Identification and molecular modeling of novel endogenous activator proteins of Sirt-1: an in silico study
Creators: name: A., Shanitha
name: Sudhakar, Manu
name: Nair, Achuthsankar S.
name: Kamalamma, Saja
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Sirt-1 is one of the most extensively studied mammalian Sirtuins that deacetylates histones and several non-histone proteins critical to cellular homeostasis. As a key sensor of cellular metabolism, it is regulated at multiple levels including transcriptional and post translational levels. As an allosteric enzyme, its activity is also modulated by ligands and certain endogenous proteins. The present study is an in silico approach to identify novel Sirt-1 binding proteins. Bioinformatic search for similarity in sequence, structure, and topology of binding region to Lamin-A, a known activator of Sirt-1, identified three proteins viz. Epididymis secretory sperm binding protein (ESSBP), xylosyltransferase 1 (XT-1), and Adenylyl cyclase 9 (ADCY-9). Molecular docking studies revealed binding of ESSBP and ADCY-9 to the N-terminal region of Sirt-1 while XT-1 docks at both N-terminal and C-terminal region of Sirt-1 with Z-Dock score better than Lamin-A; XT-1 and ADCY-9 showed better Z-Rank score as well. MD simulation studies for extended time followed by MM-PBSA analysis showed that the Sirt-1-protein complexes were stable with favourable binding energy and minimal change in RMSD relating to backbone structure and RMSF relating to residue fluctuations. Further, H-bond analysis showed only minimal changes in H bonding interactions. Docking of these proteins to Sirt-1 through interaction with several residues particularly to its N-terminal region spanning 1–243 residues, in a manner similar to the docking of the activator Lamin-A and different from the inhibitor DLBC-1 binding site, suggests that these proteins may also positively modulate Sirt-1 activity. Further experimental data would be required to validate the computational prediction and to understand its physiological role. Communicated by Ramaswamy H. Sarma
Midiendo la calidad de la informacion gestionada: algunas reflexiones conceptuales-metodologicas
Creators: name: González-Valiente, C. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: The study, based on a documental classic analysis, presents conceptual and methodological guidelines concerning the design of methodologies that help to measure the quality of information that is managed in organizations. It is described the process of information management and the importance of implementing quality principles in it. There are exposed the four dimensions of information quality as part of an indicators integration which characterize the informational contents. There are defined each of the phases in the methodological design to evaluate the information. There also are indicated the implications of this activity for information professionals.
description: in Spanish
Glycerol-3-Phosphate Acyltransferase-2 Is Expressed in Spermatic Germ Cells and Incorporates Arachidonic Acid into Triacylglycerols
Creators: name: Rabassa, Martin E.
name: Pellon-Maison, Magali
name: Gonzalez-Baro, Maria R.
name: Lacunza, Ezequiel
name: Coleman, Rosalind A.
name: Cattaneo, Elizabeth R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundDe novo glycerolipid synthesis begins with the acylation of glycerol-3 phosphate catalyzed by glycerol-3-phosphate acyltransferase (GPAT). In mammals, at least four GPAT isoforms have been described, differing in their cell and tissue locations and sensitivity to sulfhydryl reagents. In this work we show that mitochondrial GPAT2 overexpression in CHO-K1 cells increased TAG content and both GPAT and AGPAT activities 2-fold with arachidonoyl-CoA as a substrate, indicating specificity for this fatty acid.Methods and ResultsIncubation of GPAT2-transfected CHO-K1 cells with [1-14C]arachidonate for 3 h increased incorporation of [14C]arachidonate into TAG by 40%. Consistently, arachidonic acid was present in the TAG fraction of cells that overexpressed GPAT2, but not in control cells, corroborating GPAT2's role in synthesizing TAG that is rich in arachidonic acid. In rat and mouse testis, Gpat2 mRNA was expressed only in primary spermatocytes; the protein was also detected in late stages of spermatogenesis. During rat sexual maturation, both the testicular TAG content and the arachidonic acid content in the TAG fraction peaked at 30 d, matching the highest expression of Gpat2 mRNA and protein.ConclusionsThese results strongly suggest that GPAT2 expression is linked to arachidonoyl-CoA incorporation into TAG in spermatogenic germ cells.
Identification of small molecule modulators of class II transactivator-I using computational approaches
Creators: name: Nagasubramanian, Kishore
name: Jha, Shanker
name: Rathore, Anuranjan Singh
name: Gupta, Krishnakant
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Major histocompatibility complex II (MHCII), a mediator of the innate and adaptive immune system, plays a central role in regulating inflammation and its progression. Class II transactivator (CIITA) is a master regulator of MHCII expression and controls antigen presentation followed by T-cell activation. Regulation of inflammation by modulation of CIITA has been suggested as a promising intervention for several disorders, including neuroinflammation, rheumatoid arthritis and other autoimmune diseases. This study aimed to (i) identify possible pharmacological agents which could bind to and inhibit isoform I of CIITA (CIITA-I) and (ii) determine their strength of interactions. The structure of CIITA-I isoform was predicted using phyre2 and refined via 3D refine. Loops were refined using ModBase, followed by quality assessment based on ERRAT value. The refined 3D structure was subjected to docking via Maestro (from Schrodinger) using glide module against small molecule databases. Molecules having the least glide score and favorable ADME properties were subjected to molecular simulation by GROMACS. We used the 3D refined structure of CIITA-I, with a score of 83.4% in ERRAT for docking studies. The ligand 4-(2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl) thio) acetamido) benzamide (ZINC5154833), showed maximum glide score (−6.591) followed by N-[4-(3-oxo-3-{4-[3-(trifluoromethyl) phenyl] piperazin-1-yl} propyl)-1,3-thiazol-2-yl] benzamide (F5254-0161, glide score −6.41). Simulation studies using GROMACS showed F5254-0161 to have a more stable interaction with CIITA-I. Based on our analysis, we propose ZINC5154833 and F5254-0161 as potential modulators for CIITA-I. Communicated by Ramaswamy H. Sarma
Fannie Mae National Housing Survey Monthly Key Indicators-November, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
Screening of potential antiplasmodial agents targeting cysteine protease-Falcipain 2: a computational pipeline
Creators: name: Verma, Kanika
name: Lahariya, Ayush Kumar
name: Verma, Garima
name: Kumari, Monika
name: Gupta, Divanshi
name: Maurya, Neha
name: Verma, Anil Kumar
name: Mani, Ashutosh
name: Schneider, Kristan Alexander
name: Bharti, Praveen Kumar
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The spread of antimalarial drug resistance is a substantial challenge in achieving global malaria elimination. Consequently, the identification of novel therapeutic candidates is a global health priority. Malaria parasite necessitates hemoglobin degradation for its survival, which is mediated by Falcipain 2 (FP2), a promising antimalarial target. In particular, FP2 is a key enzyme in the erythrocytic stage of the parasite’s life cycle. Here, we report the screening of approved drugs listed in DrugBank using a computational pipeline that includes drug-likeness, toxicity assessments, oral toxicity evaluation, oral bioavailability, docking analysis, maximum common substructure (MCS) and molecular dynamics (MD) Simulations analysis to identify capable FP2 inhibitors, which are hence potential antiplasmodial agents. A total of 45 drugs were identified, which have positive drug-likeness, no toxic features and good bioavailability. Among these, six drugs showed good binding affinity towards FP2 compared to E64, an epoxide known to inhibit FP2. Notably, two of them, Cefalotin and Cefoxitin, shared the highest MCS with E64, which suggests that they possess similar biological activity as E64. In an investigation using MD for 100 ns, Cefalotin and Cefoxitin showed adequate protein compactness as well as satisfactory complex stability. Overall, these computational approach findings can be applied for designing and developing specific inhibitors or new antimalarial agents for the treatment of malaria infections. Communicated by Ramaswamy H. Sarma
Fast Disk Conformal Parameterization of Simply-connected Open Surfaces
Creators: name: Choi, Pui Tung
name: Lui, Lok Ming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Geometry (cs.CG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: Multimedia (cs.MM)
subject: Differential Geometry (math.DG)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Surface parameterizations have been widely used in computer graphics and geometry processing. In particular, as simply-connected open surfaces are conformally equivalent to the unit disk, it is desirable to compute the disk conformal parameterizations of the surfaces. In this paper, we propose a novel algorithm for the conformal parameterization of a simply-connected open surface onto the unit disk, which significantly speeds up the computation, enhances the conformality and stability, and guarantees the bijectivity. The conformality distortions at the inner region and on the boundary are corrected by two steps, with the aid of an iterative scheme using quasi-conformal theories. Experimental results demonstrate the effectiveness of our proposed method.
Fannie Mae National Housing Survey Monthly Key Indicators-December, 2013 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); change in income (1); household expenses (1).
A CLASS OF LOGARITHMIC-CUM-EXPONENTIAL ESTIMATORS FOR POPULATION MEAN WITH RISK ANALYSIS USING DOUBLE SAMPLING
Creators: name: Diwakar Shukla
name: Astha Jain
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Exponential estimator
Logarithmic estimator
Mean squared error
Bias
Risk function
Risk Analysis
Survey sampling
Double sampling
Simple random sampling without replacement( SRSWOR)

description: In order to improve upon the efficiency of an estimate in double sampling for estimating population mean of character under study using an auxiliary variable, a part of survey resources are used to collect the information on auxiliary variable. Some authors have suggested exponential-type estimators and some others advocated for log-type estimators. But combination of such is required for specific situation. This paper presents a class of logarithmic-cum-exponential ratio estimators in double sampling setup. The expressions for the mean squared error and bias of the proposed class of estimators are derived for two different cases(sub-sample and independent sample). Sometimes the persons involved in the sample survey have to undergo for risk on life. For example, data collection in naxalites area, working in intense forest, interview during spread of epidemic or data collection in politically disturbed region. Such risk may affect the accuracy, efficiency of estimation. A linear Risk function is used for the proposed class of estimators. Two cases of double sampling are compared in terms of relative efficiency in view to risk aspect.It is found that the proposed class of estimators has a lower mean squared error than the simple mean estimator, usual ratio, usual exponential, usual log estimators in the double sampling setup. In addition, these theoretical results are supported by a numerical example. Risk function based simulated study is performed for the support of findings of the content. Optimal sample sizes under risk are derived and compared under two cases.
ALGORITHMS FOR APPROXIMATING A FUNCTION BASED ON INACCURATE OBSERVATIONS
Creators: name: G.Sh. Tsitsiashvili
name: M.A. Osipova
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: trigonometric functions
inaccurate observations
error in function estimation
experimental plan

description: This paper is devoted to the approximation of a function by a trigonometric polynomial based on its inaccurate values at selected points. Two methods of observation are considered. The first method is to make observations at points evenly distributed on the segment where the function is specified. The second method is to take observations at the points of division into a finite number of equal parts of the neighbourhoods of the selected points. Upper estimates of the standard deviation of the function from trigonometric polynomials are constructed and the rate of their convergence is estimated. Differences were found in the computational complexity of these approximations and in the number of observations of the function values at the selected points. Thus, the problem of approximating a function from inaccurate observations of their values at selected points is a multi-criteria one and its solution depends on the choice of observation points.
Impact of WACC on Firm Profitability: Evidence from Food and Allied Industry of Bangladesh
Creators: name: Rahman, Farhana
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: The research paper aims to analyze the underlying relationship in between the profitability and cost of funds of a firm. A total of twelve companies were selected as a sample for this study which are listed in Dhaka Stock Exchange under Food and Allied Industry. A panel data set of 15 years from 2005 to 2019 was used to conduct the necessary analysis. In this paper, Return on Asset (ROA) is used as the accounting criteria of profitability. WACC is the independent variable while Firm Size, Firm Age and Firm Leverage are used as control variable for the study. Fixed Effects Panel Regression Model is used to analyze the dataset. The result of the analysis shows that WACC is negatively related with the profitability measure and this relationship is significant. The study has potential to be replicated by other industries like textile, cement, pharmaceutical & chemical, fuel & power, tannery etc.
A PAndAS view of M31 dwarf elliptical satellites: NGC147 and NGC185
Creators: name: Crnojević, D.
name: Ferguson, A. M. N.
name: Irwin, M. J.
name: McConnachie, A. W.
name: Bernard, E. J.
name: Fardal, M. A.
name: Ibata, R. A.
name: Lewis, G. F.
name: Martin, N. F.
name: Navarro, J. F.
name: Noël, N. E. D.
name: Pasetto, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We exploit data from the Pan-Andromeda Archaeological Survey (PAndAS) to study the extended structures of M31's dwarf elliptical companions, NGC147 and NGC185. Our wide-field, homogeneous photometry allows to construct deep colour-magnitude diagrams (CMDs) which reach down to $\sim3$ mag below the red giant branch (RGB) tip. We trace the stellar components of the galaxies to surface brightness of $μ_g \sim 32$ mag arcsec$^{-2}$ and show they have much larger extents ($\sim5$ kpc radii) than previously recognised. While NGC185 retains a regular shape in its peripheral regions, NGC147 exhibits pronounced isophotal twisting due to the emergence of symmetric tidal tails. We fit single Sersic models to composite surface brightness profiles constructed from diffuse light and star counts and find that NGC147 has an effective radius almost 3 times that of NGC185. In both cases, the effective radii that we calculate are larger by a factor of $\sim2$ compared to most literature values. We also calculate revised total magnitudes of $M_g=-15.36\pm0.04$ for NGC185 and $M_g=-16.36\pm0.04$ for NGC147. Using photometric metallicities computed for RGB stars, we find NGC185 to exhibit a metallicity gradient of [Fe/H]$\sim-0.15$ dex/kpc over the radial range 0.125 to 0.5 deg. On the other hand, NGC147 exhibits almost no metallicity gradient, $\sim-0.02$ dex/kpc from 0.2 to 0.6 deg. The differences in the structure and stellar populations in the outskirts of these systems suggest that tidal influences have played an important role in governing the evolution of NGC147.
description: 17 pages, 13 figures; MNRAS accepted
Weak lensing in the blue: a counter-intuitive strategy for stratospheric observations
Creators: name: Shaaban, Mohamed M.
name: Gill, Ajay S.
name: McCleary, Jacqueline
name: Massey, Richard J.
name: Benton, Steven J.
name: Brown, Anthony M.
name: Damaren, Christopher J.
name: Eifler, Tim
name: Fraisse, Aurelien A.
name: Everett, Spencer
name: Galloway, Mathew N.
name: Henderson, Michael
name: Holder, Bradley
name: Huff, Eric M.
name: Jauzac, Mathilde
name: Jones, William C.
name: Lagattuta, David
name: Leung, Jason
name: Li, Lun
name: Nagy, Thuy Vy T. Luu Johanna M.
name: Netterfield, C. Barth
name: Redmond, Susan F.
name: Rhodes, Jason D.
name: Robertson, Andrew
name: Schmoll, Jurgen
name: Sirks, Ellen
name: Sivanandam, Suresh
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The statistical power of weak lensing measurements is principally driven by the number of high redshift galaxies whose shapes are resolved. Conventional wisdom and physical intuition suggest this is optimised by deep imaging at long (red or near IR) wavelengths, to avoid losing redshifted Balmer break and Lyman break galaxies. We use the synthetic Emission Line EL-COSMOS catalogue to simulate lensing observations using different filters, from various altitudes. Here were predict the number of exposures to achieve a target z > 0.3 source density, using off-the-shelf and custom filters. Ground-based observations are easily better at red wavelengths, as (more narrowly) are space-based observations. However, we find that SuperBIT, a diffraction-limited observatory operating in the stratosphere, should instead perform its lensing-quality observations at blue wavelengths.