Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Creators: name: Delanty, Norman
name: Fisher, Simon E
name: Byerley, William F.
name: Wendland, Jens R
name: Craddock, Nick
name: Ferrucci, Luigi
name: Fanous, Ayman H
name: Mather, Karen A.
name: Li, Miaoxin
name: Martin, Nicholas G.
name: Melle, Ingrid
name: Cohen, David
name: Pütz, Benno
name: Keller, Matthew C
name: Ann Chong, Siow
name: St Clair, David
name: Eichhammer, Peter
name: Seidman, Larry J.
name: Jack, Clifford R.
name: Drevets, Wayne C
name: Meyer-Lindenberg, Andreas
name: Yao, Yin
name: Müller-Myhsok, Bertram
name: Qin Wu, Jing
name: Dikeos, Dimitris
name: Albus, Margot
name: Lopez, Lorna M.
name: Mowry, Bryan J.
name: Dale, Anders M.
name: Carless, Melanie A.
name: Kucinskas, Vaidutis
name: Kähler, Anna K.
name: Roiz-Santiañez, Roberto
name: Pocklington, Andrew J.
name: Simon Xi, Hualin
name: Wen, Wei
name: O'Donovan, Michael C.
name: Ramasamy, Adaikalavan
name: O'Dushlaine, Colm
name: Djurovic, Srdjan
name: Fox, Peter T.
name: Hegenscheid, Katrin
name: Kochunov, Peter
name: Schmaal, Lianne
name: Lencz, Todd
name: Penninx, Brenda W.J.H.
name: Cookson, Mark R.
name: Black, Donald W.
name: Freedman, Robert
name: Levinson, Douglas F.
name: Hartberg, Cecilie B.
name: Dudbridge, Frank
name: Laurent, Claudine
name: Valdés Hernández, Maria C.
name: Straub, Richard E.
name: Hulshoff Pol, Hilleke E.
name: Mattingsdal, Morten
name: Nelis, Mari
name: Liang, Kung-Yee
name: Wolf, Christiane
name: Walsh, Dermot
name: Reichenberg, Abraham
name: Klein, Marieke
name: Cai, Guiqing
name: Szatkiewicz, Jin P.
name: Wassink, Thomas H.
name: Li, Qingqin S.
name: Scott Stroup, 
name: Limborska, Svetlana
name: Drapeau, Elodie
name: Royle, Natalie A.
name: Amin, Farooq
name: Espeseth, Thomas
name: Hoogman, Martine
name: Stahl, Eli A.
name: Knight, Jo
name: Hofman, Andrea
name: Fromer, Menachem
name: Arias-Vasquez, Alejandro
name: Gurling, Hugh
name: van Haren, Neeltje E.M.
name: Nyquist, Paul
name: Holsboer, Florian
name: Nestadt, Gerald
name: Aribisala, Benjamin S.
name: Lerer, Bernard
name: Brouwer, Rachel M.
name: Svrakic, Dragan M
name: Keil, Maria
name: Homuth, Georg
name: Kuzelova-Ptackova, Hana
name: Van Os, Jim
name: Johnson, Robert
name: Lee Chee Keong, Jimmy
name: Guadalupe, Tulio
name: Hashimoto, Ryota
name: Holmans, Peter A.
name: Franke, Barbara
name: Parkhomenko, Elena
name: Liu, Xinmin
name: Brunner, Han G
name: van Tol, Marie-Jose
name: Schall, Ulrich
name: Heslenfeld, Dirk J.
name: Zheng, Xuebin
name: Salomaa, Veikko
name: Schulze, Thomas G.
name: Meijer, Carin J.
name: Zonderman, Alan
name: Nilsson, Lars G.
name: Nikitina-Zake, Liene
name: Rietschel, Marcella
name: Rosen, Glenn D.
name: Buitelaar, Jan K
name: Del Favero, Jurgen
name: Nalls, Michael A.
name: Blackwood, Douglas H.R.
name: Fernández, Guillén
name: Loughland, Carmel M.
name: Olvera, Rene L.
name: van 't Ent, Dennis
name: Crowley, James J.
name: Perkins, Diana O.
name: Desrivières, Sylvane
name: Sussmann, Jessika E.
name: Paus, Tomas
name: Luting, Xue
name: Rasmussen, Henrik B
name: Nichols, Thomas E.
name: Cairns, Murray J.
name: Grimm, Oliver
name: Weiner, Michael W.
name: Visscher, Peter M.
name: Bevilacqua, Elizabeth
name: Zai, Clement C.
name: Sämann, Philipp G.
name: Cheung, Eric F.C.
name: Curtis, David
name: Marsal, Sara
name: Matarin, Mar
name: Gibbs, Raphael
name: Suvisaari, Jaana
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name: Pike, G. Bruce
name: Iwata, Nakao
name: Chambert, Kimberley D.
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name: Steen, Vidar M.
name: Klovins, Janis
name: Giddaluru, Sudheer
name: Toro, Roberto
name: Ehrenreich, Hannelore
name: Alexander, Madeline
name: Mokrab, Younes
name: Nertney, Deborah A
name: Bacanu, Silviu A.
name: Fukunaga, Masaki
name: Bernard, Manon
name: Ching, Christopher R.K.
name: Czisch, Michael
name: Walton, Esther
name: Hoffmann, Wolfgang
name: Mohnke, Sebastian
name: Ophoff, Roel A.
name: Shen, Li
name: LeHellard, Stephanie
name: Kent, Jack W.
name: van Duijn, Cornelia M.
name: Roussos, Panos
name: Papiol, Sergi
name: Hougaard, David M.
name: Reimers, Mark A.
name: van Hulzen, Kimm J.E.
name: Anttila, Verneri
name: Göring, Harald H.H.
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name: Pietiläinen, Olli
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name: Mattay, Venkata S.
name: Demontis, Ditte
name: Davidson, Michael
name: Powell, John
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name: Jenkinson, Mark
name: Nisenbaum, Laura
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name: Stein, Jason L
name: Depondt, Chantal
name: Hosten, Norbert
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name: Bis, Joshua C.
name: Singleton, Andrew
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name: Donohoe, Gary
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name: Sullivan, Patrick F.
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name: van Bokhoven, Hans
name: van Donkelaar, Marjolein M.J.
name: Chakravarty, M. Mallar
name: Michie, Patricia T.
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name: Zimprich, Fritz
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name: Meisenzahl, Eva
name: Liewald, David C.M.
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name: Cavalleri, Gianpiero L.
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name: Milani, Lili
name: Tooney, Paul A.
name: Naber, Marlies A.M.
name: Arepalli, Sampath
name: Magnusson, Patrik K.E.
name: Kasperaviciute, Dalia
name: Abramovic, Lucija
name: Hottenga, Jouke-Jan
name: Papadimitriou, George N.
name: Vinke, Louis N
name: Wang, Qiang
name: Hernandez, Dena G.
name: Needham, Margaret
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name: Herms, Stefan L.
name: Mallet, Jacques
name: Schubert, Christian R
name: Kendler, Kenneth S.
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name: Silverman, Jeremy M.
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name: Frank, Josef
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name: Hong Lee, 
name: Erk, Susanne
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name: Seiler, Stephan
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name: Becker, James T.
name: Haroutunian, Vahram
name: Green, Robert C.
name: Scolnick, Edward M.
name: Salami, Alireza
name: Agartz, Ingrid
name: Hartman, Catharina A.
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name: Ruderfer, Douglas M.
name: Macek Jr, Milan
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name: Begemann, Martin
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name: Boks, Marco P.
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name: Wormley, Brandon K.
name: Armstrong, Nicola J.
name: Li, Tao
name: Spencer, Chris C.A.
name: Owen, Michael J.
name: Williams, Stephanie
name: Julià, Antonio
name: Escott-Price, Valentina
name: Moran, Jennifer L.
name: Blangero, John
name: Mortensen, Preben B.
name: Buxbaum, Joseph D.
name: Slominsky, Petr
name: Sim, Kang
name: Pulver, Ann E.
name: de Zubicaray, Greig I.
name: Jahanshad, Neda
name: Fischl, Bruce
name: Kelly, Brian J.
name: Chauhan, Ganesh
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name: Schmidt, Helena
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name: den Braber, Anouk
name: Hager, Reinmar
name: Waddington, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders.