Peanut‐induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry
Creators: name: Maris, Ioana
name: Dölle‐Bierke, Sabine
name: Renaudin, Jean‐Marie
name: Lange, Lars
name: Koehli, Alice
name: Spindler, Thomas
name: Hourihane, Jonathan
name: Scherer, Kathrin
name: Nemat, Katja
name: Kemen, C.
name: Neustädter, Irena
name: Vogelberg, Christian
name: Reese, Thomas
name: Yildiz, Ismail
name: Szepfalusi, Zsolt
name: Ott, Hagen
name: Straube, Helen
name: Papadopoulos, Nikolaos G.
name: Hämmerling, Susanne
name: Staden, Ute
name: Polz, Michael
name: Mustakov, Tihomir
name: Cichocka‐Jarosz, Ewa
name: Cocco, Renata
name: Fiocchi, Alessandro Giovanni
name: Fernandez‐Rivas, Montserrat
name: Worm, Margitta
name: Grünhagen, J
name: Wittenberg, M
name: Beyer, K
name: Henschel, A
name: Küper, S
name: Möser, A
name: Fuchs, T
name: Ruëff, F
name: Wedi, B
name: Hansen, G
name: Buck, T
name: Büsselberg, J
name: Drägerdt, R
name: Pfeffer, L
name: Dickel, H
name: Körner‐Rettberg, C
name: Merk, H
name: Lehmann, S
name: Bauer, A
name: Nordwig, A
name: Zeil, S
name: Hannapp, C
name: Wagner, N
name: Rietschel, E
name: Hunzelmann, N
name: Huseynow, I
name: Treudler, R
name: Aurich, S
name: Prenzel, F
name: Klimek, L
name: Pfaar, O
name: Reider, N
name: Aberer, W
name: Varga, E
name: Bogatu, B
name: Schmid‐Grendelmeier, P
name: Guggenheim, R
name: Riffelmann, F
name: Kreft, B
name: Kinaciyan, K
name: Hartl, L
name: Ebner, C
name: Horak, F
name: Brehler, R
name: Witte, J
name: Buss, M
name: Hompes, S
name: Bieber, T
name: Gernert, S
name: Bücheler, M
name: Rabe, U
name: Brosi, W
name: Nestoris, S
name: Hawranek, T
name: Lang, R
name: Bruns, R
name: Pföhler, C
name: Eng, P
name: Schweitzer‐Krantz, S
name: Meller, S
name: Rebmann, H
name: Fischer, J
name: Stichtenoth, G
name: Thies, S
name: Gerstlauer, M
name: Utz, P
name: Neustädter, I
name: Klinge, J
name: Volkmuth, S
name: Plank‐Habibi, S
name: Schilling, B
name: Kleinheinz, A
name: Brückner, A
name: Schäkel, K
name: Manolaraki, I
name: Kowalski, M
name: Solarewicz‐Madajek, K
name: Tscheiller, S
name: Seidenberg, J
name: Cardona, V
name: Garcia, B
name: Bilo, M
name: Cabañes Higuero, N
name: Vega Castro, A
name: Poziomkowska‐Gęsicka, I
name: Büsing, S
name: Virchow, C
name: Christoff, G
name: Jappe, U
name: Müller, S
name: Knöpfel, F
name: Correard, A‐K
name: Rogala, B
name: Montoro, A
name: Brandes, A
name: Muraro, A
name: Zimmermann, N
name: Hernandez, D
name: Minale, P
name: Niederwimmer, J
name: Zahel, B
name: Dahdah, L
name: Arasi, S
name: Reissig, A
name: Eitelberger, F
name: Asero, R
name: Hermann, F
name: Zeidler, S
name: Pistauer, S
name: Geißler, M
name: Ensina, L
name: Plaza Martin, A
name: Meister, J
name: Stieglitz, S
name: Hamelmann, E
name: Network For Online Registration Of Anaphylaxis (NORA)
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: anaphylaxis
subject: food allergy
subject: paediatrics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Methods Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre. Results 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p &lt; .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&amp;Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004). Conclusions The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.