cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EnGraft: a multicentre, open-label, randomised, two-arm, superiority study protocol to assess bioavailability and practicability of Envarsus® versus Advagraf™ in liver transplant recipients
Creators: name: Wöhl, D. S.
name: James, B.
name: Götz, M.
name: Brennfleck, F.
name: Holub-Hayles, I.
name: Mutzbauer, I.
name: Baccar, S.
name: Brunner, S. M.
name: Geissler, E. K.
name: Schlitt, H. J.
name: Vondran, Florian W. R.
name: Herden, Uta
name: Mittler, Jens
name: Neumann, Ulf Peter
name: Nadalin, Silvio
name: Schnitzbauer, Andreas A.
name: Rauchfuß, Falk
name: Braun, Felix
name: Willuweit, Katharina
name: Pratschke, Johann
name: Berg, Thomas
name: Vogel, Thomas
name: Merle, Uta
name: Croner, Roland
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: EnGraft, Envarsus, Liver transplantation, Superiority study, Randomised controlled trial
subject: 610 Medizin

description: Background
Graft rejection and chronic CNI toxicity remain obstacles to organ transplant success. Current formulations of tacrolimus, such as Prograf® and Advagraf™, exhibit limitations in terms of pharmacokinetics and tolerability, related in part to suboptimal bioavailability. As dosing non-compliance can result in graft rejection, the once daily formulation of tacrolimus, Advagraf™, was developed (vs 2x/day Prograf®). Benefits of Advagraf™ are counterbalanced by delayed achievement of therapeutic trough levels and need for up to 50% higher doses to maintain Prograf®-equivalent troughs. Envarsus® is also a prolonged-release once-daily tacrolimus formulation, developed using MeltDose™ drug-delivery technology to increase drug bioavailability; improved bioavailability results in low patient drug absorption variability and less pronounced peak-to-trough fluctuations. In phase III de novo kidney transplant studies, Envarsus® proved non-inferior to twice-daily tacrolimus; however, no phase IV studies show superiority of Envarsus® vs Advagraf™ in de novo liver transplant (LTx) recipients.
Methods
The EnGraft compares bioavailability and tests superiority of Envarsus® (test arm) versus Advagraf™ (comparator arm) in de novo LTx recipients. A total of 268 patients from 15 German transplant centres will be randomised 1:1 within 14 days post-LTx. The primary endpoint is dose-normalised trough level (C/D ratio) measured 12 weeks after randomisation. Secondary endpoints include the number of dose adjustments, time to reach first defined trough level and incidence of graft rejections. Additionally, clinical and laboratory parameters will be assessed over a 3-year period.
Discussion
C/D ratio is an estimate for tacrolimus bioavailability. Improving bioavailability and increasing C/D ratio using Envarsus could reduce renal dysfunction and other tacrolimus-related toxicities; previous trials have shown that a higher C/D ratio (i.e. slower tacrolimus metabolism) is not only associated with improved renal function but also linked to reduced neurotoxic side effects. A higher C/D ratio could improve clinical outcomes for LTx recipients; EnGraft has begun, with one third of patients recruited by January 2022.
Advancing oral immunology for improving oral health
Creators: name: Deschner, James
name: Schröder, Agnes
name: Weber, Manuel
name: Galler, Kerstin
name: Proff, Peter
name: Kirschneck, Christian
name: Bozec, Aline
name: Jantsch, Jonathan
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Immune system · Oral diseases · Oral microbiota · Immune responses · Host microbial interactions
subject: 610 Medizin

description: Although substantial progress has been made in dentistry in terms of diagnosis and therapy, current treatment methods in periodontology, orthodontics, endodontics, and oral and maxillofacial surgery, nevertheless, suffer from numerous limitations, some of which are associated with a dramatic reduction in the quality of life. Many general mechanisms of inflammation and immunity also apply to the oral cavity and oral diseases. Nonetheless, there are special features here that are attributable, on the one hand, to developmental biology and, on the other hand, to the specific anatomical situation, which is characterized by a close spatial relationship of soft and hard tissues, exposure to oral microbiota, and to a rapid changing external environment. Currently, a comprehensive and overarching understanding is lacking about how the immune system functions in oral tissues (oral immunology) and how oral immune responses contribute to oral health and disease. Since advances in translational immunology have created a game-changing shift in therapy in rheumatology, allergic diseases, inflammatory bowel disease, and oncology in recent years, it is reasonable to assume that a better understanding of oral immunology might lead to practice-changing diagnostic procedures and therapies in dentistry and thereby also profoundly improve oral health in general.
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study
Creators: name: Herold, Janina M.
name: Nano, Jana
name: Gorski, Mathias
name: Winkler, Thomas W.
name: Stanzick, Kira J.
name: Zimmermann, Martina E.
name: Brandl, Caroline
name: Peters, Annette
name: Koenig, Wolfgang
name: Burkhardt, Ralph
name: Gessner, André
name: Heid, Iris M.
name: Gieger, Christian
name: Stark, Klaus J.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Polygenic scores, PGS, General adults, Elderly, Kidney function biomarkers, eGFRcrea, eGFRcys
subject: 610 Medizin

description: Background
Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFRcrea) have been applied in various study populations with different age ranges. This has shown that PGS explain less eGFRcrea variance in the elderly. Our aim was to understand how differences in eGFR variance and the percentage explained by PGS varies between population of general adults and elderly.
Results
We derived a PGS for cystatin-based eGFR (eGFRcys) from published genome-wide association studies. We used the 634 variants known for eGFRcrea and the 204 variants identified for eGFRcys to calculate the PGS in two comparable studies capturing a general adult and an elderly population, KORA S4 (n = 2,900; age 24–69 years) and AugUR (n = 2,272, age ≥ 70 years). To identify potential factors determining age-dependent differences on the PGS-explained variance, we evaluated the PGS variance, the eGFR variance, and the beta estimates of PGS association on eGFR. Specifically, we compared frequencies of eGFR-lowering alleles between general adult and elderly individuals and analyzed the influence of comorbidities and medication intake. The PGS for eGFRcrea explained almost twice as much (R2 = 9.6%) of age-/sex adjusted eGFR variance in the general adults compared to the elderly (4.6%). This difference was less pronounced for the PGS for eGFRcys (4.7% or 3.6%, respectively). The beta-estimate of the PGS on eGFRcrea was higher in the general adults compared to the elderly, but similar for the PGS on eGFRcys. The eGFR variance in the elderly was reduced by accounting for comorbidities and medication intake, but this did not explain the difference in R2-values. Allele frequencies between general adult and elderly individuals showed no significant differences except for one variant near APOE (rs429358). We found no enrichment of eGFR-protective alleles in the elderly compared to general adults.
Conclusions
We concluded that the difference in explained variance by PGS was due to the higher age- and sex-adjusted eGFR variance in the elderly and, for eGFRcrea, also by a lower PGS association beta-estimate. Our results provide little evidence for survival or selection bias.
Fractionated stereotactic radiotherapy of brain metastases: results of a retrospective study
Creators: name: Gruber, Isabella
name: Stark, Philipp
name: Weidner, Karin
name: Treutwein, Marius
name: Koelbl, Oliver
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Fractionated stereotactic radiotherapy; Brain metastases; Brain radiation necrosis; Malignant melanoma; Renal cell cancer
subject: 530 Physik
subject: 610 Medizin

description: Background
Lasting local control of brain metastases following stereotactic radiotherapy is becoming increasingly relevant since systemic treatment constantly improves the prognosis of patients with extracranial metastases.

Methods
73 patients with 103 brain metastases received hypofractionated stereotactic radiotherapy (FSRT) in 6 fractions of 5 Gy between January 2017 and December 2021 at the University Hospital Regensburg, Germany. The study retrospectively evaluated local progression free survival (LPFS), overall survival (OS) and distant brain progression free survival (DPFS) of patients without prior radiotherapy of the brain. Response rate and brain radiation necrosis were reported. Cox proportional hazard models evaluated prognostic factors of OS and LPFS.

Results
The median patient age was 61.0 years (Interquartile range, IQR 51.0, 67.5). The most common tumor types were malignant melanoma (34.2%) and non-small cell lung adenocarcinoma (26.0%). The median gross tumor volume (GTV) was 0.9 cm³ (IQR 0.4, 3.6). The median follow-up time of all patients was 36.3 months (95%CI 29.1, 43.4). The median OS was 17.4 months (95%CI 9.9, 24.9). Overall survival rates at 6-, 12-, 18-, 24-, and 30 months were 81.9%, 59.1%, 49.0%, 41.3%, and 37.2%, retrospectively. The mean LPFS was 38.1 months (95%CI 31.4, 44.9), while the median LPFS has not been reached. LPFS rates at 6-, 12-, 18-, 24- and 30 months were 78.9%, 68.7%, 64.3%, 61.6% and 58.7%, retrospectively. Median DPFS of all patients was 7.7 months (95%CI 6.1, 9.3). Six, 12-, 18-, 24- and 30 months DPFS rates were 62.1%, 36.3%, 31.1%, 24.8% and 21.7%. Five brain metastases (4.8%) developed brain radiation necrosis. In multivariate analysis, the number of brain metastases negatively affected LPFS. Non-melanoma and non-renal cell cancer was associated with a higher chance of LPFS in comparison to other cancer. A GTV > 1.5 cm³ translated into a higher risk of death compared to a GTV ≤ 1.5 cm³ and Karnofsky performance score was predictive of OS.

Conclusions
FSRT in 6 fractions of 5 Gy seems to be an effective treatment with an acceptable local control for patients with brain metastases although melanoma and renal cell cancer seem to have a worse local control in comparison to other cancer.
MOESM1 of Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation
Creators: name: Andersen, Stephen
name: Candry, Pieter
name: Thais Basadre
name: Khor, Way
name: Roume, Hugo
name: Hernandez-Sanabria, Emma
name: Coma, Marta
name: Korneel Rabaey
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Further information on composition and microbial community abundance in the applied current and control thin stillage fermentations.
Termitomorpha Wasman
Creators: name: Silva, Ruan Felipe Da
name: Caron, Edilson
name: Carvalho-Filho, Fernando Da Silva
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Termitomorpha

description: Key to the species of Termitomorpha
Adapted from Caron et al. (2018)
1 External margin of metafemur with arcuate emargination in proximal 2/3 (Fig. 3F)................ T. fissipennis (Casey)
- External margin of metafemur without arcuate emargination (Figs. 9F, G, 16F).................................... 2
2 Mandible with medial teeth (Figs. 2B, 8B, 15B)............................................................ 3
- Mandible without medial teeth (Kistner 2006, fig. 25B–C)...................................... T. huachii Seevers
3 Pronotum with sinuous lateral margin..................................................................... 4
- Pronotum with straight lateral margin (Fig. 15C; Caron et al. (2018), fig. 45)..................................... 7
4 Mentum with distal margin almost straight................................................................. 5
- Mentum with distal margin conspicuously arcuate........................................................... 6
5 Prosternum broadly elevated at middle.................................................... T. meinerti Wasmann
- Prosternum not elevated at middle................................................... T. costaricensis (Seevers)
6 Antennal article I with about the length of articles II to V combined (Caron et al. 2018, fig. 7)............................................................................................... T. sinuosa Caron, Bortoluzzi & Rosa.
- Antennal article I nearly the length of articles II to IV combined (Fig. 8E)........................ T. goeldiana sp. nov.
7 Pronotum with anterior margin strongly notched medially (Caron et al. (2018), fig. 45)....... T. alata Caron & Bortoluzzi
- Pronotum with base slightly notched medially (Fig. 15C)....................................... T. manni (Seevers)
description: Published as part of Silva, Ruan Felipe Da, Caron, Edilson & Carvalho-Filho, Fernando Da Silva, 2022, An update on Termitomorpha Wasman (Coleoptera: Staphylinidae) including a new species, species redescriptions and geographic extension, pp. 1-25 in Zootaxa 5205 (1) on pages 23-24, DOI: 10.11646/zootaxa.5205.1.1, http://zenodo.org/record/7285081
Additional file 1: of Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer
Creators: name: Hoyne, Gerard
name: Rudnicka, Caroline
name: Sang, Qing-Xiang
name: Roycik, Mark
name: Howarth, Sarah
name: Leedman, Peter
name: Schlaich, Markus
name: Candy, Patrick
name: Matthews, Vance
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Figure S1. Human prostate cancer cells proliferate faster than normal prostate epithelial cells. Cell proliferation was measured by MTS assay 1, 3 and 5 days after cells were seeded (0.25x105 cells/mL on day 0); n = 12 samples/cell type/time point; mean +/- SEM; *p
Additional file 1: Table S1. of Cardiovascular risk outcome and program evaluation of a cluster randomised controlled trial of a community-based, lay peer led program for people with diabetes
Creators: name: M. Riddell
name: J. Dunbar
name: P. Absetz
name: R. Wolfe
name: H. Li
name: M. Brand
name: Z. Aziz
name: B. Oldenburg
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Diabetes Self-care behaviours: Changes over 12 months between intervention and usual care groups in Diabetes Self-care behaviours. This table details the mean baseline and 12 month measures of diabetes self-care behaviour [35, 55] for the intervention and usual care groups and compares the change overtime between the intervention and usual care group. Table S2. MDS – support and satisfaction of support friends/ health care team: Changes over 12 months between intervention and usual care groups in perception of support received. This table details the mean baseline and 12 month measures of perceived support from family and health care team [36] in the intervention and usual care groups and compares the change overtime between the intervention and usual care group. (DOCX 23 kb)
MOESM1 of Molecular genetics of naringenin
            biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus
Creators: name: Álvarez-Álvarez, Rubén
name: Botas, Alma
name: Albillos, Silvia
name: Rumbero, Angel
name: Martín, Juan
name: Liras, Paloma
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Figure S1. A) Conserved sequences around the key amino acids located in chalcone synthases active center. The numbers given in the sequence correspond to S. clavuligerus Ncs, where the key amino acids are Cys138, Phe188, His270 and Asn303. B) Phylogenetic three of plant and Streptomyces chalcone synthases. The origin of the sequences used is indicated at the right side. Numbers at the far right side correspond to the genetic distance index.
Eigenständige Analgesie mit Piritramid durch Notfallsanitäter – retrospektive Auswertung der elektronischen Einsatzdokumentation
Creators: name: Dittmar, Michael S.
name: Kneißl, Katharina
name: Schlickeisen, Julia
name: Lamprecht, Christoph
name: Kraus, Martin
name: Glaser, Christian
name: Kanz, Karl-Georg
name: Nickl, Stephan
name: Parsch, Axel
name: Schiele, Albert
name: Prückner, Stephan
name: Bayeff-Filloff, Michael
name: Trentzsch, Heiko
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Emergency medical services · Medical director · Professional delegation · EMS standing orders · Extremity trauma
subject: 610 Medizin

description: Hintergrund
Schmerzen sind ein häufiger Behandlungsgrund in der prähospitalen Notfallmedizin. In Bayern delegieren die Ärztlichen Leiter Rettungsdienst (ÄLRD) bei subjektiv nichttolerablen Schmerzen nach isoliertem Extremitätentrauma an Notfallsanitäter (NotSan) landesweit einheitlich die Kurzinfusion von 7,5 mg des Opioidanalgetikums Piritramid.
Methode
Die Routineeinsatzdokumentation aller Einsätze im bayerischen Rettungsdienst mit Heranziehungen des Delegationsalgorithmus „Isolierte Extremitätenverletzung“ der ÄLRD nach § 4 Abs. 2 Nr. 2c Notfallsanitätergesetz wurde über einen 2‑Jahres-Zeitraum ausgewertet. Evaluiert wurden der Effekt auf die Schmerzintensität nach der numerischen Rating-Skala (NRS) und dem Vorliegen nichttolerabler Schmerzen, Auswirkungen auf die Vitalfunktionen sowie die Notwendigkeit von bestimmten weitergehenden Interventionen.
Ergebnisse
Bei 7151 identifizierten Einsätzen erfolgte in 6097 Fällen eine eigenständige Analgesie durch NotSan entlang der Delegation der ÄLRD. Die Schmerzintensität nach der NRS konnte von im Median 7 (Interquartilsabstand [IQR] 2) auf 3 (IQR 2, p < 0,001) gesenkt und in 96,9 % ein aus Patientensicht tolerables Niveau erreicht werden. In 9,4 % der Fälle wurde ein Notarzt nachgefordert und in 5,0 % eine ergänzende Analgesie verabreicht. Etwa jeder zehnte Patient erhielt Sauerstoff. Atemwegsinterventionen waren in wenigen Einzelfällen notwendig, eine Antagonisierung nur nach höheren als den delegierten Opiatdosen.
Schlussfolgerung
Eine vom ÄLRD delegierte und von NotSan eigenständig durchgeführte Opiatgabe senkt das Schmerzniveau relevant. Wesentliche Hinweise auf eine Patientengefährdung fanden sich nicht. Durch dieses Verfahren konnten in Bayern jährlich geschätzt ca. 2500 Notarzteinsätze vermieden werden.
Stroudia maria Gusenleitner & Rsa 2019, nov.sp.
Creators: name: Gusenleitner, Josef
name: Rsa, Namibia and
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Stroudia
Stroudia maria

description: Stroudia maria nov.sp. ♀ (Abb. 18-20)
Holotypus: RSA, W CAPE, Lamberts Bay, Coast, 29.10.1999, ♀, leg. M. Halada. coll. OLM.
Paratypen: Funddaten wie Holotypus, 2♀♀; RSA, W CAPE, 5 km S Lambers Bay, 20.11.2002, 1♀, leg. M. Halada; S of Lamberts Bay, 28.10.1999, 1♀, leg. M. Snižek, alle coll. OLM.
Diese Art ist ähnlich Stroudia sexpunctata (GIORDANI SOIKA, 1934) (Abb. 16, 17), aber unter anderem ist der Clypeus dichter punktiert, das Pronotum ist an den Schultern abgerundet und das 1. Tergit zwischen den Punkten glänzend, nicht matt.
♀ (Abb. 18): bei schwarzer Grundfarbe sind weiss gefärbt: schmale Querbinde an der Basis des Clypeus, breite in der Mitte unterbrochene Binde vorne auf dem Pronotum, Flecken auf den Tegulae, Endbinden auf den Tergiten 1 und 2. Rot gefärbt sind distale Hälften der Mandibeln und Beine ab den Schenkeln. Flügel sind hell durchscheinend.
Clypeus (Abb. 19) grob punktiert, Punkte fliessen zum Teil der Länge nach zusammen; Ausschnitt schmal und tief. Fühlerschäfte dicht und grob punktuliert. Stirn, Scheitel und Schläfen sehr dicht punktiert. Punktzwischenräume sehr schmal und eine Punktulierung ist selten zu erkennen. Pronotum hat abgerundete Schultern und ist wie Mesonotum, Schildchen, Hinterschildchen und Mesopleuren gleichmässig punktiert; Punktzwischenräume schmal und dicht punktuliert. Propodeum weitläufiger punktiert und die Punktulierung auf den Zwischenräumen fehlt, aber die Seitenwände sind dicht mikroskopisch quer gestreift. Tegulae glänzend und vorne mit dichter Punktulierung. Beine glänzen nicht.
1. Tergit (Abb. 20) etwas länger als breit und mit grober Punktierung. Die glänzenden Punktzwischenräume sind grösser als die Punktdurchmesser. Vor der hellen Endbinde mit Querfurche. 2. Tergit feiner als das 1. Tergit punktiert, die Zwischenräume sind matt, Der eingedrückte bräunlich durchscheinende Endsaum hat an der Basis eine Punktreihe. 2. Sternit entspricht dem 2. Tergit und die Tergite und Sternite 3 bis 6 sind fein strukturiert.
Behaarung ist nicht zu erkennen, nur die Mesopleuren haben eine anliegende silbrige Pubeszenz.
Länge: 9 mm.
Das ♂ ist nicht bekannt.
Diese Art wurde meiner Betreuerin Maria Blašková aus der Slowakei gewidmet.
description: Published as part of Gusenleitner, Josef & Rsa, Namibia and, 2019, Bemerkenswerte Faltenwespen aus der äthiopischen Region. Teil 14 (Hymenoptera, Vespidae, Eumeninae), pp. 811-819 in Linzer biologische Beiträge 51 (2) on page 813, DOI: 10.5281/zenodo.3738627
Additional file 1: Table S1. of Forewing color pattern in Micropterigidae (Insecta: Lepidoptera): homologies between contrast boundaries, and a revised hypothesis for the origin of symmetry systems
Creators: name: Schachat, Sandra
name: Brown, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plant Biology

description: Non-Sabatinca wing pattern variation. Table S2. Sabatinca wing pattern variation from New Zealand. Table S3. Sabatinca wing pattern variation from New Caledonia. (DOC 145Â kb)
Additional file 1: of Recognition of mental disorders among a multiracial population in Southeast Asia
Creators: name: Siow Chong
name: Edimansyah Abdin
name: Picco, Louisa
name: Pang, Shirlene
name: Jeyagurunathan, Anitha
name: Janhavi Vaingankar
name: Kwok, Kian
name: Mythily Subramaniam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: All the vignettes administered in this study are available in the supplementary file. (DOCX 18Â kb)
Teslasena foucarti Chassain 2005
Creators: name: Rosa, Simone Policena
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Elateridae
Teslasena
Teslasena foucarti

description: Teslasena foucarti Chassain, 2005
 (Fig. 34C)
 Teslasena foucarti Chassain, 2005: 66.
 Redescription (male, Fig. 34C): Integument brown to black, legs lighter. Total length 9.0-12.0 mm; elytra 2.3-2.4 times longer than pronotum. Head concave or with a median circular depression, frontal carina straight between antennal insertions; IEP 0.25-0.35 antenna reaching or surpassing the hind angle of pronotum by one antennomere. Pronotum 1.05-1.10x wider than long, with double punctation on disc, larger punctures 0.5-1.0 diameters apart, denser on lateral borders; densely pilose with long decumbent setae. Scutellum covered with short setae. Elytra tapered apicad from humerus.
 Aedeagus: Phallobase 0.31x the total length of aedeagus, 1.10x longer than wide, length ratio between lateroposterior and median parts 4.3; penis: basal triangular part with sides straight, apical part 0.71x as long as the triangular basal part; with a ventral sclerite.
 Holotype: [Brésil, (Mato Grosso), 14°15’50.80”S, 59°14’02.05”W, Chapada dos Parecis], [30 km N d’Uirapuru, Usine Alcomat, 1 au 15-XII-2001, A. Foucart leg.], [Holotype], [Teslasena foucarti sp. nov., Holotype, J. Chassain det. 04], male (MNHN).
 Paratypes: same data as holotype, 4 exs. (MNHN), 1 ex. (MZUSP).
 Distribution: BRAZIL. Mato Grosso: Chapada dos Parecis.
 Remarks: T. foucarti (Fig. 34C) was detailed described by Chassain (2005), who distinguished this species from T. femoralis in the shape of the anterior margin of frons, which is straight in T. foucarti, its antennomeres relatively longer, the pronotum narrower anteriorly with punctation larger on lateral and anterior borders and the metatibial inner spur with tip curved. As discussed above, the analysis of a large series of T. femoralis revealed that those features, with the exception of the curved metatibial spur, are highly variable among the specimens and do not constitute consistent diagnostic characters. On the other hand, the curved tip of the metatibial inner spur was observed only in T. foucarti specimens, which also present body pilosity longer. The most evident difference in the pilosity of these species was observed in the pronotum, which is moderately long and usually dense on T. foucarti and absent or minuscule and scarce in T. femoralis. Their aedeagus do not present significant differences.
description: Published as part of Rosa, Simone Policena, 2014, Phylogenetic analysis and taxonomic revision of Physodactylinae (Coleoptera, Elateridae), pp. 217-292 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (18) on pages 231-232, DOI: 10.1590/0031-1049.2014.54.18, http://zenodo.org/record/12641367
Additional file 8: Table S5. of Discovery and mapping of genomic regions governing economically important traits of Basmati rice
Creators: name: Lakshminarayana Vemireddy
name: Noor, Sabahat
name: VV Satyavathi
name: A Srividhya
name: A Kaliappan
name: SRN Parimala
name: Prathibha Bharathi
name: Dondapati Deborah
name: KV Rao
name: N Shobharani
name: EA Siddiq
name: Javaregowda Nagaraju
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 60506 Virology

description: Quantitative trait loci (QTLs) detected in theÂ RIL population derived from Basmati370/Jaya. (DOC 38 kb)
Additional file 8: Figure S6. of A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1
Creators: name: Canal, Frédéric
name: Anthony, Elodie
name: Lescure, Aurianne
name: Nery, Elaine Del
name: Camonis, Jacques
name: Perez, Franck
name: Ragazzon, Bruno
name: Perret, Christine
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: HCT116WT/S45del and HCT116WT/- cell growth in response to knockdown of potential lethal synthetic hits HGS; STRADA, FES, BRAF and PKMYT1. HCT116WT/S45del and HCT116WT/- cells were transfected with scramble siRNA or with siRNAs specifically designed to target HGS, STRADA, FES, BRAF or PKMYT1. Untransfected cells were also included as a control. Cell density was estimated 72 h after cell transfection by crystal violet staining, and the effect of siRNA on cell proliferation was determined by the ratio ‘O.D. target siRNA’/ ‘O.D. scramble siRNA’. Gray and black rows show the proliferation rate of HCT116WT/S45del and HCT116WT/- cells (relative to scamble), respectively. Note that cell proliferation was affected by the silencing of each genes, both in HCT116WT/S45del and HCT116WT/- cells, except for HGS, the depletion of which affected specifically HCT116WT/S45del cells. (PDF 92 kb)
Idiotropia Schwarz 1897
Creators: name: Rosa, Simone Policena
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Elateridae
Idiotropia

description: Idiotropia Schwarz, 1897
 Athous Eschscholtz, 1829 (pars); Abeille de Perrin, 1894: 91.
 Idiotropa Schwarz, 1897: 63 (misspelling recognized by Schwarz, 1906: 314).
 Idiotropia Schwarz, 1906: 310, 314; Schenkling, 1927: 510.
 Type species (by monotypy): Athous henoni Abeille de Perrin, 1894.
 Diagnosis (male): Frontal carina absent, mandibles long, bidentate directed anteriorly; pronotum quadrate, weakly convex, sides widened anteriorly, anterior angles right not produced, posterior angle without carina; scutellum cordiform wider than long, convex and perpendicular to mesoscutum at base; elytra subparallel to posterior third, not fused to each other, wings absent; legs narrow, tibia and tarsomeres 1-2 with spiniform setae, tibial spurs robust, longer than setae, tarsomeres and claws simple.
 Distribution: ALGERIA.
description: Published as part of Rosa, Simone Policena, 2014, Phylogenetic analysis and taxonomic revision of Physodactylinae (Coleoptera, Elateridae), pp. 217-292 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (18) on page 232, DOI: 10.1590/0031-1049.2014.54.18, http://zenodo.org/record/12641367
Additional file 7: Table S4. of Discovery and mapping of genomic regions governing economically important traits of Basmati rice
Creators: name: Lakshminarayana Vemireddy
name: Noor, Sabahat
name: VV Satyavathi
name: A Srividhya
name: A Kaliappan
name: SRN Parimala
name: Prathibha Bharathi
name: Dondapati Deborah
name: KV Rao
name: N Shobharani
name: EA Siddiq
name: Javaregowda Nagaraju
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Quantitative trait loci (QTLs) detected in F3 population of Basmati370/Jaya. (DOC 35 kb)
Additional file 3: Figure S3. of CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
Creators: name: Tanouchi, Aki
name: Taniuchi, Keisuke
name: Mutsuo Furihata
name: Naganuma, Seiji
name: Dabanaka, Ken
name: Kimura, Masashi
name: Watanabe, Ryohei
name: Takuhiro Kohsaki
name: Shimizu, Takahiro
name: Saito, Motoaki
name: Hanazaki, Kazuhiro
name: Saibara, Toshiji
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Subcellular localization of CCDC88A and AMPK1 in PANC-1 cells. Confocal immunofluorescence microscopic images of PANC-1 cells that were cultured on fibronectin and were then labeled with anti-AMPK1 antibody (green), anti-CCDC88A antibody (red) and phalloidin (violet; actin filaments). Arrows, AMPK1 localized in cell protrusions. Blue, nuclear DAPI staining. Bar, 10 Îźm. (DOCX 631 kb)
Additional file 2: Table S2. of Sociodemographic characteristics associated with alcohol use among low-income Mexican older adults
Creators: name: Aguila, Emma
name: Guerrero, Erick
name: Vega, William
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Wave 1 Characteristics Attriters and Panel (DOC 54Â kb)
Head and neck oncology management in the time of COVID-19: results of a head and neck cancer center
Creators: name: Heckel, Silvia
name: Bohr, Christopher
name: Meier, Johannes
name: Maurer, Julia
name: Kuenzel, Julian
name: Mueller, Karolina
name: Koelbl, Oliver
name: Reichert, Torsten E.
name: Vielsmeier, Veronika
name: Gruber, Isabella
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Pandemic · COVID-19 · Cancer care · Oncologic surgery · Head and neck cancer · Oncological performance
subject: 610 Medizin

description: Purpose

Given the concerns about the effects of the COVID-19 pandemic on cancer care, we analyzed the treatment quality of the head and neck cancer center Regensburg before and throughout 2 years of the pandemic. We included data of 3 years to reflect the extended pandemic period as new developments continued to influence its course.
Methods

This retrospective review included all patients diagnosed with head and neck cancer in 2019, 2020, and 2021 who had not started treatment elsewhere prior to being referred to the head and neck cancer center. We compared tumor characteristics and times to therapy of patients diagnosed before COVID-19 in 2019 (n = 253), during COVID-19 in 2020 (n = 206), and in a phase of partial normalization in a persistent pandemic situation in 2021 (n = 247).
Results

Our data revealed no decrease in diagnoses or drift in stages toward more advanced stages. There was an increased percentage of diagnoses confirmed at the head and neck cancer center from 2019 (57.3%) to 2020 (68.0%) and to 2021 (65.6%) compared to confirmation at other institutions (2019, 42.7%; 2020, 32.0%; 2021, 34.4%; P = 0.041). Surgery and radiotherapy were performed with the same frequency. The median days between diagnosis and surgery were decreased in 2020 (19.5 days; P = 0.049) and 2021 (20.0 days; P = 0.026) in comparison to 2019 (23 days). The days to radiotherapy were not affected.
Conclusion

The data indicate a consistent oncological performance for head and neck cancer patients in all waves of the pandemic and thereafter without a decrease in diagnoses or shift in stages.
Additional file 1: of Sequence specificity between interacting and non-interacting homologs identifies interface residues â   a homodimer and monomer use case
Creators: name: Qingzhen Hou
name: Dutilh, Bas
name: Huynen, Martijn
name: Heringa, Jaap
name: K. Feenstra
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Contains all the figures and tables that supplement the descriptions of the experiment in the main text. (PDF 1116 kb)
Additional file 2: of Systematic review of patient safety interventions in dentistry
Creators: name: Bailey, Edmund
name: Tickle, Martin
name: Campbell, Stephen
name: OâMalley, Lucy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Search Strategy (completed on 28.2.2014) (DOCX 15 kb)
Additional file 1: Table S1. of Sociodemographic characteristics associated with alcohol use among low-income Mexican older adults
Creators: name: Aguila, Emma
name: Guerrero, Erick
name: Vega, William
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Plant Biology
subject: FOS: Biological sciences

description: Wave 1 Characteristics Deceased and Alive (DOC 54Â kb)
Toxognathus coomani Fleutiaux 1940
Creators: name: Rosa, Simone Policena
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Elateridae
Toxognathus
Toxognathus coomani

description: Toxognathus coomani Fleutiaux, 1940
 (Figs. 8, 34H)
 Toxognathus coomani Fleutiaux, 1940a: 35.
 Redescription (male, 39H): Integument brown to dark brown, legs and antennae lighter. Total length 5.5-6.5 mm; elytral base 1.03-1.08x as wide as pronotum, elytra 2.65-2.67x longer than pronotum. Frons concave along the anterior margin; frontal carina complete. Antennae surpassing the posterior angle of pronotum by one antennomere; antennomeres IV-X as long as wide and convex. Mandible bidentate (Fig. 8A). Pronotum (Fig. 8B) flattened 1.11-1.16x wider than long with sides slightly rounded, convergent on anterior 1/4; lateral carina entirely lateroventral (not visible from dorsal view) (Figs. 8C, D), posterior angles subparallel and convex; posterior margin with a pair of lateral incisions adjacent to the posterior angles; punctures 0.5 diameter apart on disc, coalescent on lateral border. Elytral interstices convex. Free margin of metacoxal plate short, triangular; tibiae slightly widened apicad with dorsal apical angle truncate. Tergite IX with anterior margin bisinuous.
 Aedeagus (Figs. 8G, H): Phallobase 0.37x total length of aedeagus, 1.2x longer than wide, length ratio between lateroposterior and median parts 3; paramere with ventral anteromedian margin acute; basal struts 0.28x total length of penis; ventral sclerite linear.
 Holotype: [Ton Kin, (Lac Thô), Hoa Binh, A. de Cooman], [Toxognathus coomani, type, Collection Fleutiaux], [Type], [Muséum Paris, Coll. E. Fleutiaux], [Toxognathus coomani (Fleutiaux), J. Chassain det. 05], [Lectotype], (MNHN).
 Material examined: VETNAM. Tonkin, 4 exs. (MNHN).
 Distribution: VIETNAM. Hoa Binh: Lac Thuy.
 Remarks: Toxognathus coomani shares with T. mouhoti and T. fairmarei the bidentate mandibles. It is most similar to T. mouhoti by its body size, eye size, shape of prothorax, free margin of metacoxal plate short and triangular and widened tibiae. It can be distinguished mainly by its frons, which is concave along the anterior border, complete frontal carina, shorter antenna and a pair of short notches on posterior margin of pronotum.
description: Published as part of Rosa, Simone Policena, 2014, Phylogenetic analysis and taxonomic revision of Physodactylinae (Coleoptera, Elateridae), pp. 217-292 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (18) on pages 241-242, DOI: 10.1590/0031-1049.2014.54.18, http://zenodo.org/record/12641367
Additional file 5: Figure S3. of Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems
Creators: name: A. OâCallaghan
name: F. Bottacini
name: M. OâConnell Motherway
name: D. Van Sinderen
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Restriction analysis of B. longum genomic DNA. Restriction analysis of genomic DNA from B. longum subsp. longum NCIMB 8809 and B. longum subsp. longum CCUG 30698. Lane 1, molecular weight marker (Bioline). Lane 2: Unrestricted total DNA from B. longum subsp. longum NCIMB 8809, Lane 3 and 4 total B. longum subsp. longum NCIMB 8809 DNA restricted with lane 3 EcoRII and lane 4 PstI. Lane 5: Unrestricted total DNA from B. longum subsp. longum CCUG 30698, Lane 6 and 7 total B. longum subsp. longum CCUG 30698 DNA restricted with lane 6 EcoRII and lane 7 PstI. (PDF 93 kb)
Additional file 1: of Systematic review of patient safety interventions in dentistry
Creators: name: Bailey, Edmund
name: Tickle, Martin
name: Campbell, Stephen
name: OâMalley, Lucy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: PRISMA 2009 Checklist. (PDF 106 kb)
Additional file 1: Table S1. of Common variants in SIRT1 and human longevity in a Chinese population
Creators: name: Lin, Rong
name: Dongjing Yan
name: Yunxia Zhang
name: Xiaoping Liao
name: Gong, Gu
name: Junjie Hu
name: Yunxin Fu
name: Wangwei Cai
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Details for single-nucleotide polymorphisms (SNPs) tagged by genotyped SNPs. Table S2. Genotype and allele frequencies of SIRT1 polymorphisms in the Chinese Han long-lived individuals and controls. Table S3. Association of SIRT1 haplotypes with human longevity in the Chinese Han long-lived individuals and controls. Table S4. Genotype and allele frequencies of SIRT1 polymorphisms in the long-lived individuals and controls when stratified by gender. Table S5. Association of SIRT1 haplotypes with human longevity when stratified by gender. Table S6. Association studies of SIRT1 with human longevity. (DOC 226 kb)
Changes in adenoviral chromatin organization precede early gene activation upon infection
Creators: name: Schwartz, Uwe
name: Komatsu, Tetsuro
name: Huber, Claudia
name: Lagadec, Floriane
name: Baumgartl, Conradin
name: Silberhorn, Elisabeth
name: Nuetzel, Margit
name: Rayne, Fabienne
name: Basyuk, Eugenia
name: Bertrand, Edouard
name: Rehli, Michael
name: Wodrich, Harald
name: Laengst, Gernot
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: adenovirus; chromatin remodeling; early infection; pVII; transcription
subject: 500 Naturwissenschaften
subject: 570 Biowissenschaften, Biologie

description: Within the virion, adenovirus DNA associates with the virus-encoded, protamine-like structural protein pVII. Whether this association is organized, and how genome packaging changes during infection and subsequent transcriptional activation is currently unclear. Here, we combined RNA-seq, MNase-seq, ChIP-seq, and single genome imaging during early adenovirus infection to unveil the structure- and time-resolved dynamics of viral chromatin changes as well as their correlation with gene transcription. Our MNase mapping data indicates that the adenoviral genome is arranged in precisely positioned nucleoprotein particles with nucleosome-like characteristics, that we term adenosomes. We identified 238 adenosomes that are positioned by a DNA sequence code and protect about 60–70 bp of DNA. The incoming adenoviral genome is more accessible at early gene loci that undergo additional chromatin de-condensation upon infection. Histone H3.3 containing nucleosomes specifically replaces pVII at distinct genomic sites and at the transcription start sites of early genes. Acetylation of H3.3 is predominant at the transcription start sites and precedes transcriptional activation. Based on our results, we propose a central role for the viral pVII nucleoprotein architecture, which is required for the dynamic structural changes during early infection, including the regulation of nucleosome assembly prior to transcription initiation. Our study thus may aid the rational development of recombinant adenoviral vectors exhibiting sustained expression in gene therapy.
Additional file 3: of Systematic review of patient safety interventions in dentistry
Creators: name: Bailey, Edmund
name: Tickle, Martin
name: Campbell, Stephen
name: OâMalley, Lucy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Characteristics of excluded studies. (DOC 148 kb)