cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optimization on biodistribution and antitumor activity of tripterine using polymeric nanoparticles through RES saturation
Creators: name: Yin, Juntao
name: Wang, Peiqing
name: Yin, Yuyun
name: Hou, Yantao
name: Song, Xiaoyong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Cancer

description: Systemic delivery of tripterine (TPR) is challenged by its insoluble property and unsuitable pharmacokinetics. This work aimed to develop polymeric nanoparticles (NPs) combined with the reticuloendothelial system (RES) saturation to improve the in vivo distribution and antitumor activity of TPR. TPR-loaded nanoparticles (TPR-NPs) were prepared by the low-energy emulsification/evaporation method and characterized with particle size, entrapment efficiency, and morphology. The resulting TPR-NPs were 75 nm around in particle size and displayed a sustained drug release in pH 7.4 medium. Pharmacokinetic studies revealed that TPR-NPs had the advantage in bettering the pharmacokinetic properties of TPR over the solution formulation. However, the ameliorative effect on pharmacokinetics was more significant in the case of RES saturation (i.e. preinjection of blank NPs). Preinjection of blank NPs followed by injection of TPR-NPs resulted in higher distribution of TPR into the tumor due to reduced sequestration of TPR-NPs by RES. In tumor-bearing mice (prostatic cancer model), TPR-NPs treatment with RES saturation exhibited a superior antitumor efficacy to free TPR and TPR-NPs alone. It can be concluded that formulating TPR into polymeric NPs in combination with RES saturation is an effective means to address the systemic delivery of TPR.
Sonnenfleckenzeichnung Nr. 23337 (Replikat).
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.05.1970, erstellt von Werner Scheidegger.
Zusätzlich ist vermerkt: Sonnenturm.
Die Nummer 23337, bereits benutzt für die originale Zeichnung vom 06.05.1970, wurde mit dem Vermerk "Copie", hier "Copia specolare", ergänzt
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Ergänzende Angaben aufgrund auswärtiger Beobachtungen sind auch hier direkt auf der Fleckenzeichnung hinzugefügt
Performance and cost effectiveness of centralized infiltration basins and decentralized low impact development practices ina semi-arid urban watershed
Creators: name: Sochanska, Marianna Dorota
Publisher: name: University of Utah
Year: 2014

description: Low impact development (LID) is gaining popularity for its ability to revert developed landscapes to their historical hydrology and thus enhance sustainability. Utilizing a case study of a low impact development in the Salt Lake City Valley in Utah, a comparison of the effects of centralized infiltration to different LID technologies was conducted. Stormwater simulated rainfall-runoff models were created using the U.S. Environmental Protection Agency's Storm Water Management Model (SWMM). To evaluate several scenarios models with different features were developed: no controls (developed land with no stormwater control); centralized infiltration (large infiltration basins); rainwater harvesting (rain barrels); porous pavement; bioretention; and a comprehensive model with all of the LID features together. The results of the models show statistically significant (p<0.05 and t stat>t critical) decreases in average annual total flow volume, average annual mean flows, and average annual peak flows from the no controls model. For all reductions, a comparison of model performance in wet and dry years (a classification based on precipitation amounts) was completed. This revealed that the centralized infiltration model performs better in dry years, the comprehensive LID, porous pavement, and bioretention models perform better in wet years, and finally that rainwater harvesting generates similar reductions in outflow regardless of the type of year. A cost analysis of the models was conducted in order to help quantify the use of the technologies. In terms of costs per volume reductions, bioretention proved to be the least expensive option, followed by rainwater harvesting, centralized infiltration basins, comprehensive LID, and finally porous pavement. Based on these results, the final recommendation is that projects should first consider bioretention and then rainwater harvesting as options for stormwater management. Porous pavement is an effective choice, however, its cost is a deterrent. Comprehensive LID model provides successful reductions but at a higher cost due to the inclusion of porous pavement. Centralized infiltration is still a good choice for new developments since it is shown to be very effective, however the land amount it requires for implementation may be a deterrent for using this type of stormwater management in retrofitting projects.
Sonnenfleckenzeichnung Nr. 23393.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Study of the sulphur in coal and its distribution between the gases and the residue in coking
Creators: name: Wenger, Arthur W.
Publisher: name: University of Utah
Year: 2012
Subjects: Coke
Coal-tar products
Sulphur
Coal, Utah

description: Sulphur exists in metallurgical coke as a source of annoyance and difficulties in the economic progress of the metal industries. It ie present in coal in several different forms under two heads as organic and inorganic sulphur. The percentage of the forms vary widely in different coals.  In the manufacture of coke, varying ajnounte of sulphur a=a retained by the same coal under different methods of carbonization, and, by different coals under the same method of treatment .  It is desirable to know the factors that influence the distribution of the element between the gases and the residues of coal in the manufacture of metallurgical coke, and, for that reason it is an important problem at present which means a saving of millions of dollars to the metal industry.  Analyses of the forms of sulphur in several samples of Utah coals appear elsewhere in this paper. The samples were received from the offices of the yards in Salt Lake Oity and analyzed according to the methods used by Prof- S. W. Parr and A. R. Powell on several Eastern coals.
Sonnenfleckenzeichnung Nr. 23432.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Electrosteric stealth Rivastigmine loaded liposomes for brain targeting: preparation, characterization, ex vivo, bio-distribution and in vivo pharmacokinetic studies
Creators: name: El-Helaly, Sara Nageeb
name: Elbary, Ahmed Abd
name: Kassem, Mohamed A.
name: El-Nabarawi, Mohamed A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Being one of the highly effective drugs in treatment of Alzheimer’s disease, Rivastigmine brain targeting is highly demandable, therefore liposomal dispersion of Rivastigmine was prepared containing 2 mol% PEG-DSPE added to Lecithin, Didecyldimethyl ammonium bromide (DDAB), Tween 80 in 1:0.02:0.25 molar ratio. A major challenge during the preparation of liposomes is maintaining a stable formulation, therefore the aim of our study was to increase liposomal stability by addition of DDAB to give an electrostatic stability and PEG-DSPE to increase stability by steric hindrance, yielding what we called an electrosteric stealth (ESS) liposomes. A medium nano-sized liposome (478 ± 4.94 nm) with a nearly neutral zeta potential (ZP, −8 ± 0.2 mV) and an entrapment efficiency percentage of 48 ± 6.22 was prepared. Stability studies showed no major alteration after three months storage period concerning particle size, polydispersity index, ZP, entrapment efficiency and in vitro release study confirming the successful formation of a stable liposomes. No histopathological alteration was recorded for ESS liposomes of the sheep nasal mucosa. While ESS liposomes showed higher % of drug permeating through the sheep nasal mucosa (48.6%) than the drug solution (28.7%). On completing the in vivo pharmacokinetic studies of 36 rabbits showed 424.2% relative bioavailability of the mean plasma levels of the formula ESS compared to that of RHT intranasal solution and 486% relative bioavailability of the mean brain levels.
The role of Cox20 in Cox2 maturation and cytochrome C oxidase assembly
Creators: name: Ferris, Elliott Carter
Publisher: name: University of Utah
Year: 2012
Subjects: Cox2
Cox20
Cyclooxygenase 2
Cyclooxygenases
Cytochrome oxidase
C oxidase assembly
Mitochondrial respiration
Cox2 assembly factor

description: Proper assembly of Cytochrome c Oxidase (CcO) is vital to mitochondrial respiration. The metallation and incorporation of CcO subunit 2 (Cox2) are important  assembly steps that remain poorly understood. The Cox2 assembly factor Cox20 may provide a unique window on CcO assembly. Cox20 is known to bind Cox2 before the latter is incorporated into the larger CcO assembly in S. cerevisiae. Conservation of  Cox20 in higher organisms and the lethality of its deletion in Drosophila melanogaster may suggest Cox20 plays a conserved role in CcO assembly.  In an attempt to understand the nature of the hypothesized conserved role of Cox20, conserved residues within Cox20 were mutated and the resulting mutants studied.  Mutation of a conserved cysteine pair impacted mitochondrial respiration, but did not block CcO assembly. The mutant Cox20 C87A forms a mixed disulfide species.  Identifying the partner molecule may shed light on the role of Cox20.  The present study finds Cox20, a 23 kD protein, in high molecular weight complexes that are unlikely to be homo-oligomeric. Identifying any other proteins in  these complexes may shed light on the role Cox20 plays in CcO assembly. To this end, Cox20 was purified and analyzed by mass spectrometry (MS) to identify any  accompanying proteins. Small quantities of the known CcO assembly factors Mss2, Coa1, and Mss51 were identified.
Damage tolerance predictions for spar web cracking in a diminishing stress field
Creators: name: Heller, Randal Evan
Publisher: name: University of Utah
Year: 2012
Subjects: Web cracking
Damage tolerance
Fatigue
Fracture mechanics
Airplanes -- Maintenance and repair

description: Current United States Air Force (USAF) Damage Tolerance Analysis (DTA) methodology yields short crack growth lives for webs in built-up beams as used in the construction of wing spars. This results in very short inspection intervals for these types of structures. Inspection data from fleet usage and fatigue tests do not support the analytically-based assertion that spar webs are as damage tolerant critical as typically predicted. Current analytical methods involve short edge distances predicting failure when the crack reaches the edge-of-  part. In reality, there is remaining residual strength in the spar web.   Current continuing damage methods allow for cracks that grow up into the part after the lower ligament fails. The assumption for this secondary cracking has been to use the same driving force as in the initial crack. However, the high driving force from bending found near the extreme fiber diminishes as the crack grows toward the neutral axis.  This paper utilizes the test results from two specimens to help validate an analytical approach toward crack growth predictions in spar webs. The goal of this approach is to extend short inspection intervals currently required on some USAF aircraft.   I would like to thank my wife, Mindy, for all of her encouragement and support during this long effort. Without you, I never would have started. Thanks to my  children, Evan, Austin and Erin for your patience during the long hours away from home that this effort required. Thanks also to Dr. Paul Clark and Dr. Mark Thomsen of the United States Air Force. You rekindled my love of learning and convinced me that I had what it takes to tackle graduate work. A final thanks to Dr. David Hoeppner of the University of Utah Mechanical Engineering department. You have inspired me to pursue professional development and to strive to blend wisdom, skill, and ethics in all of my engineering endeavors.
Sonnenfleckenzeichnung Nr. 23498.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Induced polarization effect in time domain: theory, modeling, and applications
Creators: name: Fu, Lei
Publisher: name: University of Utah
Year: 2012
Subjects: Exploration
GEMTIP
Induced polarization
Mineral exploration
Resistivity
Time domain

description: A new theoretical and experimental method of induced polarization (IP) in the time domain is tested with resistivity data and detailed mineralogy of rock samples.  The Generalized Effective Medium Theory of Induced Polarization (GEMTIP) was originally developed in the frequency domain for explaining the structure-property  relationship of rocks. The geoelectrical parameters of this model are determined by the intrinsic petrophysical and geometric characteristics of composite media: the  mineralization and/or fluid  content of rocks and the matrix composition, porosity, anisotropy, and polarizability of formations. The physical properties of rock samples from exploration or mining sites are often used to assist in planning geological surveys or interpretation of geophysical results. However, electrical property data are often recorded in the time domain. In this paper, the Generalized Efective Medium Theory of Induced Polarization (GEMTIP) is tested with the time domain resistivity data transformed from complex resistivity data. It is demonstrated that the time-domain GEMTIP method can be used to study the induced polarization (IP) effect. Results indicate that the time domain resistivity data from laboratory measurements can be used in inversion routines. With advances in the understanding of the IP effect through the GEMTIP model and wide application of the time domain measurements, detection, and discrimination capability will improve  for porphyry systems and other geologic targets, leading to greater efficiency in mineral exploration.
Sonnenfleckenzeichnung Nr. 23403.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Pathways in the diagnosis and treatment of breast cancer: the significance of delay
Creators: name: Bungay, Hilary
Publisher: name: University of Kent
Year: 2022

description: Delay in the diagnosis and treatment of all types of cancer is now on the policy agenda. A recent government directive compels hospitals to ensure that all patients with a suspected breast cancer see a specialist within two weeks of an urgent referral from their General Practitioner. However the impact of system delay (the time taken for a women to be evaluated, diagnosed and treated once she has sought help) on the stage of disease and outcome in terms of survival is thought to be negligible. This empirical study aimed to explore the pathways that women followed in the process of diagnosis and treatment of breast cancer to determine how long each stage of the process took. To achieve this a prospective quantitative survey was undertaken that plotted the pathways of 300 women referred to three hospitals breast clinics, to determine whether differences in the organisations of services could explain any variations in the length of the process. The data was collected during observation of active clinics, and in addition interviews with health professionals and patients explored their perceptions of the process. The study found that there were differences in the way that services for patients with symptomatic breast problems were organised at each of the research sites. Variations were also found in the length of time taken for each stage of the process of diagnosis and treatment both within and between the sites. The variations in the time taken for the process appeared to reflect the differences in the way in which the sites were organised. Although the study did not explore the clinical outcome of delay, it was found to be important because of the anxiety experienced by women waiting for appointments and results. Minimising delay would reduce the length of time women suffer the anxiety of uncertainty.
Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers
Creators: name: Elkomy, Mohammed H.
name: Menshawe, Shahira F. El
name: Abou-Taleb, Heba A.
name: Elkarmalawy, Marwa H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel for transbuccal delivery of LTD. Transfersomes bearing LTD were prepared by conventional thin film hydration method and optimized using sequential Quality-by-Design approach that involved Placket–Burman design for screening followed by constrained simplex-centroid design for optimization of a Tween-80/Span-60/Span-80 mixture. The transferosomes were characterized for entrapment efficiency, particle size, and shape. Optimized transferosomes were incorporated in a mucoadhesive gel. The gel was characterized for rheology, ex vivo permeation across chicken pouch buccal mucosa, in vitro release, and mucoadhesion. Pharmacokinetic behavior of LTD formulations was investigated in healthy volunteers following administration of a single 10-mg dose. Optimal transferosomes characterized by submicron size (380 nm), spherical shape and adequate loading capacity (60%) were obtained by using quasi-equal ratio surfactant mixture. In terms of amount permeated, percentage released, and mucoadhesion time, the transferosomal gel proved superior to control, transferosome-free gel. Bioavailability of the transferosomal gel was comparable to Claritin® oral tablets. However, inter-individual variability in Cmax and AUC was reduced by 76 and 90%, respectively, when the buccal gel was used. Linear Correlation of in vitro release with in vivo buccal absorption fractions was established with excellent correlation coefficient (R2>0.97). In summary, a novel buccal delivery system for LTD was developed. However, further clinical investigation is warranted to evaluate its therapeutic effectiveness and utility.
The Effects of Educational Messaging within the Expanded Food and Nutrition Education Program
Creators: name: Snow, Mary Michelle
Publisher: name: University of Utah
Year: 2014

description: Foodborne illnesses continue to threaten the health of consumers throughout the United States, as evidenced by multiple foodborne illness outbreaks being reported annually. The leading cause of death among patients with foodborne illnesses is listeriosis. Over the years, health educators have researched, developed, and implemented multiple educational methods aimed at reducing the number of listeriosis cases. Yet, foodborne illnesses and related deaths attributed to listeriosis continue to be reported annually. Using data from the 2009 EFNEP Giving Your Body the Best curriculum (N = 588) and listeriosis photo novella development project (N = 247); we explored the effectiveness of food safety preventive messaging within the Expand Food and Nutrition Education Program (EFNEP) community. Univariate and multivariate linear regression was conducted to model the effectiveness of the Giving your Body the Best curriculum and the listeriosis photo novella messaging on food safety knowledge and preventive behaviors. This study revealed three important findings. First, EFNEP client's food related skills and food safety behaviors improved in all categories after completion of the Giving Your Body the Best curriculum. Second, both educational interventions were equally effective at increasing participant's listeriosis knowledge and preventive food preparation and storage behaviors. Lastly, 108 of 152 (71%) photo novella study participants shared iv the photo novella with 255 spouses, family, or coworkers. This study significantly contributes to the field of foodborne illness prevention in four ways. First, this is the first study to examine the effectiveness of the Giving Your Body the Best curriculum. Second, it is the first study to develop a photo novella using principles of CBPR and health behavior and health education theories. Third, this is the first study to compare the effectiveness of a photo novella with that of a traditional didactic curriculum. And lastly, it is the first study to examine the impact of the photo novella on others outside of the immediate study population. This foundational study is only the first step in understanding the effectiveness, utility, and generalizability of the Giving Your Body the Best curriculum and the use of photo novella in terms of preventive foodborne illness education.
Sonnenfleckenzeichnung Nr. 23465.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Relationships among physique, body composition and performance characteristics of preprofessional, collegiate ballet dancers
Creators: name: Gudgeon, James Michael
Publisher: name: University of Utah
Year: 2014
Subjects: Ballet dancers
Body composition
Physique

description: The purpose of this study was to examine relationships among staged appearance, technical dance skill, selected anthropometric measures and body composition in preprofessional, collegiate female ballet dancers. The subjects (n = 45) were all full time ballet majors (16-22 years) attending the University of Utah in the Dance Department. The subjects represented a variety of levels of dance proficiency. Stage appearance (STAGE) was determined by the dance faculty using a 5 point Likert scale. A technical dance skill rating (TOTAL) was derived from the sum of seven elements of dance proficiency as assessed by the faculty utilizing seven separate Likert scales. Body composition was determined by hydrostatic weighing. The following anthropometric measures were assessed: height, weight, wrist, forearm, extended biceps, shoulder, chest, waist, hips, thigh, knee, calf, and ankle girths, biacromial and bitrochanteric diameters, triceps skinfold, and waist to tip of coccyx. The zero order correlations revealed significant relationships between TOTAL and weight, wrist, forearm, extended biceps, and waist girths (r - -0.57, -0.49, -0.56, -0.56, -0.53), respectively; and STAGE and weight, percent fat, extended biceps, and waist girths (r - -0.66, -.050, -0.72, -0.69), respectively. Multiple regression analysis revealed that prediction of STAGE was best accomplished by combining the two girth measures of biceps and hip (R = 0.755). Prediction of TOTAL was best achieved with a combination of weight and % fat (R = 0.620). Factor analysis revealed that girths of the extremities measured essentially the same underlying factor; the same was revealed for girth measures of the trunk (i.e., shoulder, breast, and waist). While these results indicate that physique and body composition are related to successful performance and achievement of appearance standards in female ballet dancers, the anthropometric and body composition variables measured in this study do not account for all of the variability in dance performance capabilities or stage appearance. Further research is needed to identify additional factors which might influence success as a ballerina.
Optical quantification of hemolysis, icterus, and lipemia in human serum
Creators: name: Kasagani, Vimal Kumar
Publisher: name: University of Utah
Year: 2014
Subjects: Hemolysis
Human serum
Icterus
Lipemia
Optical

description: In order to increase the automation and efficiency for a national reference laboratory, the ability to quantify interferences like Hemolysis, Icterus, and Lipemia in serum samples is investigated. The system is intended as a screening step prior to clinical analysis of medical samples to prevent false results caused by the interferences. The system is based on selective absorption of transmitted light by the interferences that cause loss of light at specific wavelengths. The absorption spectra of interferences are analyzed to identify the appropriate wavelengths, resulting in a mathematical formulation between the absorbance and concentrations. An absorption wavelength is selected so that the transmitted power of light through a tube with the sample significantly decreased due to the presence of condition of interest, while the reference wavelength is selected so that the transmitted light varies mostly due to the presence of tube material and labels and does not vary due to the presence of interference. A computational model is formulated using a commercial software package, ANSYS FLUENT, in order to understand the absorption and scattering effects, the thermal effects of higher power irradiation on the biological samples, as well as to determine the radiant power of transmitted light through the sample for different power levels. The Discrete Ordinates Method is used to model the radiation through a participating medium. The temperature distribution and spectral power of transmitted radiation are determined for water in a tube for different wavelengths used in the current system.
Axillary and rectal temperatures in females of varying age
Creators: name: Rae, Lonieda E. Eskelson
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Pediatric Nursing

description: Temperature is used daily as criteria for diagnosis, for decision, and for plan of care; therefore, the measurement must be accurate for valid use.  However, consistant information is not available for the  placement time for taking children's temperatures, and the studies that have been done on adults show a variation in age group.  to clarify the problem, this study was done.  The hypotheses tested were the following:  1. The optimum placement time from a female child's rectal temperature will compare to within three minutes of that established for adults by Nichols, et al., which is two minutes.  2. The optimum placement time for a female child's axillary temperature will compare to within three minutes of  that established for adults by Nichols, et.al., which is nine minutes.  Temperature placement times will vary with age.  The study was done on thirty-three, normal, healthy female children who were put into groups according to age.  The three groups consisted of three year olds, six year olds, and nine year olds.  Then, axillary and rectal temperatures were taken simultaneously and read every two minutes with standardized thermometers.  The environmental temperature ranged from 72° to 78° Fahrenheit, and the same watch was used for all procedures.  The optimum, rectal placement time for the total group was six minutes.  The optimum, axillary placement time for the total group was ten minutes.  Both were longer than adult placement time in other studies.  However, the girl's rectal placement time was greater than the adults by four minutes; thus, the first hypothesis was rejected and the second accepted.  There was no significant difference between groups in this study; so the third hypothesis was rejected.
Sonnenfleckenzeichnung Nr. 23381.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Queer identity and travel agency: place-based arguments in the It Gets Better Project
Creators: name: Solomonov, Aleksandra
Publisher: name: University of Utah
Year: 2012
Subjects: Critical rhetoric
Deification
Place
Place-based arguments
Queer identity
Rural/Urban

description: Media shape and fuel migratory imaginations and are a powerful resource in selfmaking for all sorts of persons. The It Gets Better Project, a product of contemporary media, provides numerous rich texts produced by both queer and heterosexual subjects that make place-based arguments about how life gets better for queer youth. In this thesis, I explore how notions of marginality and migration are mobilized within and through rhetorics of place within the project. Using an amalgamation of critical rhetoric and queer theory, and particularly through the application of Scott Herring's concept of metronormativity, I examine the ways in which mythologies of geography-specifically, around rurality and urbanity-are configured in interesting and revealing ways for queer identity. Through a close reading of 100 video samples, my analysis yields a problematic of queerness articulated around place through the rhetorical anchors of safety, innocence, and authenticity. While urbanity is asserted as a place of safety, love, and creativity, rurality is structured as the direct opposite; the small town becomes a symbol for hostility, homophobia, and conformity. The queer individual emerges from these associations with the city as a creative agent, yet one whose self-worth is conflated with work, and more specifically, power and profit. Furthermore, culturally received notions of childhood innocence are troubled and inverted within the narratives, revealing childhood as not innocent, pure, or chaste. In this inversion, queer adulthood retains the mythical wonder of childhood; queer adulthood in the city maintains the wonder, magic, and social validation that was absent for the narrators in their youth. However, the love, magic, and discovery rearticulated with queer identity are contingent on the suppression and erasure of queer sexuality in both youth and adulthood. The narrow construction of queer identity rearticulated within the project produces an "authentic" queer identity, one that is almost exclusively based within the city and, interestingly, crafts queerness as ahistorical. Notably, the agency, creativity, asexuality, and ahistoricity of queerness that are articulated in the It Gets Better Project valorize and deify queerness, but specifically in ways that tame and contain it.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.11.1970, erstellt von Emilia Tifrea, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 23496.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
title: Piezoelectric nanofibers as biomaterials for bone regeneration and wound healing
Creators: name: Gibbs, Alex
name: McNamee, Emerson
name: Daniel, Slade
Publisher: name: URMSE
Year: 2020

description: Piezoelectric properties of materials are becoming a more relevant area of research for biomaterials. Examples of these materials are polyvinylidene fluoride (PVDF), collagen, and a combination of these with other materials like polycaprolactones (PCL) and multi-walled carbon nanotubes (MWCNT). These materials offer the unique ability to respond to an applied electric field with a mechanical response or vice versa, with an electric response to an applied mechanical force. This behavior can be instrumental in modern medicine for wound healing and bone regeneration. A variety of cells (osteoblasts, epithelial cells, mesenchymal cells) have all shown piezoelectric properties. This would allow for the use of piezoelectric materials to aid in cell migration, proliferation, and differentiation, facilitating the end goal of wound healing and bone regeneration.
Sonnenfleckenzeichnung Nr. 23411.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Absolute quantification of pharmacokinetic parameters in dynamic contrast enhanced magnetic resonance imaging
Creators: name: Fluckiger, Jacob U.
Publisher: name: University of Utah
Year: 2012
Subjects: Arterial input function
Blind estimation
DCE-MRI

description: We present a method for absolutely quantifying pharmacokinetic parameters in dynamic contrast-enhanced (DCE)-MRI. This method, known as alternating mini-mization with model (AMM), involves jointly estimating the arterial input function (AIF) and pharmacokinetic parameters from a characteristic set of measured tissue concentration curves. By blindly estimating the AIF, problems associated with  AIF measurement in pharmacokinetic modeling, such as signal saturation, flow and partial volume eff ects, and small arterial lumens can be ignored. The blind estimation  method described here introduces a novel functional form for the AIF, which serves to simplify the estimation process and reduce the deleterious e ffects of noise on  the deconvolution process. Computer simulations were undertaken to assess the performance of the estimation process as a function of the input tissue curves. A  con fidence metric for the estimation quality, based on a linear combination of the SNR and diversity of the input curves, is presented. This con fidence metric is then  used to allow for localizing the region from which input curves are drawn. Local blood supply to any particular region can then be blindly estimated, along with some  measure of con fidence for that estimation. Methods for evaluating the utility of the blind estimation algorithm on clinical data are presented, along with preliminary  results on quantifying tissue parameters in soft-tissue sarcomas.  The AMM method is applied to in vivo data from both cardiac perfusion and breast cancer scans. The cardiac scans were conducted using a dual-bolus protocol,  which provides a measure of truth for the AIF. Twenty data sets were processed with this method, and pharmacokinetic parameter values derived from the blind AIF were compared with those derived from the dual-bolus measured AIF. For seventeen of the  twenty datasets there were no statistically signifi cant  differences in Ktrans estimates. The cardiac AMM method presented here provides a way to quantify perfusion of myocardial tissue with a single injection of contrast agent and without a special pulse sequence. The resulting parameters are similar to those given by the dual bolus method. The breast cancer scans were processed with the AMM method and the results were compared to an analysis done with the semiquantitative DCE-MRI scans. The e ffects of the temporal sampling rate of the data on the AMM method are examined. The ability of the AMM-derived parameters to distinguish benign and malignant tumors is compared to more conventional methods.
Quantifying groundwater-surface water exchange: development and testing of shelby tubes and seepage blankets as discharge measurement and sample collections devices
Creators: name: Solder, John Edward Eberly
Publisher: name: University of Utah
Year: 2014
Subjects: Hydraulic conductivity
Seepage blanket
Seepage meter
Shelby tube
Specific discharge
Water exchange

description: Quantification of groundwater-surface water exchange and the role of hyporheic flow in this exchange is increasingly of interest to a wide range of disciplines (e.g., hydrogeology, geochemistry, biology, ecology). The most direct method to quantify groundwater-surface water exchange is a seepage meter, first developed in the 1940s. Widespread use of the traditional 1970s-era 55-gallon half-barrel seepage meter has shown that the method is subject to potential errors, particularly in flowing waters (e.g., streams, rivers, tidal zones). This study presents two new direct seepage measurement devices, the Shelby tube and the seepage blanket, designed to minimize potential measurement errors associated with flowing surface waters. The objective of the study is to develop and test the new methods by comparing results (specific discharge, hydraulic conductivity, and dissolved constituent concentration) to established methods. Results from both laboratory and field testing suggest that the new devices have utility in quantifying the water and dissolved constituent exchange between surface water and groundwater.
A novel tumor-activated ALA fusion protein for specific inhibition on the growth and invasion of breast cancer cells MDA-MB-231
Creators: name: Liu, Xiufeng
name: Liu, Xintong
name: Sunchen, Suwen
name: Liu, Meixia
name: Shen, Chen
name: Wu, Juanjuan
name: Zhao, Wanli
name: Yu, Boyang
name: Liu, Jihua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Objective: The aim of this research was to develop a novel ALA fusion protein for target to the malignant cells surface with high uPAR expression and locally release of the scorpion toxin AGAP in an uPA-cleavable manner. It will provide an effective approach for controlled release of the peptide toxins to treat cancerous cells. Methods: The ALA fusion proteins were expressed in pichia pastoris, and the recombinant proteins were purified by Ni-NTA affinity chromatography. The proteins were added to human breast cancer cells (MDA-MB-231) and human embryonic kidney cells (HEK-293) in order to investigate the characteristic of selective targeting and releasing of scorpion toxin AGAP in cancer cells with high uPAR expression. The inhibitory effect of ALA on MDA-MB-231, MCF7, LO2 and HEK-293 was evaluated by MTT assay. Moreover, the antiproliferation mechanism of ALA was determined by flow cytometric and western blot analysis. Results: The results showed that ALA could target MDA-MB-231 cells and the scorpion toxin AGAP could be released with high efficiency and selectivity. ALA inhibited the growth and invasion of breast cancer cells MDA-MB231. Also, cell apoptosis pathway was found to be associated with the inhibition mechanism of ALA according to the data of flow cytometric and western blot analysis. Therefore, ALA could be a novel antitumor candidate for targeting treatment of malignant cell. Conclusions: This study successfully demonstrated that fusion of biotoxins with tumor target domain could provide a simple yet effective way to delivery of peptide or protein drugs.
Statistical tools in cosmology: model selection and covariance matrix comparison
Creators: name: Ferreira, Tassia
Publisher: name: Zenodo
Year: 2021
Subjects: Cosmology
Model selection
Statistical tools
Interacting dark energy models
Covariance matrices

description: Albeit LCDM's fame as the concordance model, there are many interesting mysteries worth exploring, such as the nature of dark energy. Here, we test the viability of several classes of scenarios of the dark sector with linear and non-linear interacting terms. To do so, we use a Bayesian model selection with data from type Ia supernovae, cosmic chronometers, cosmic microwave background and two sets of baryon acoustic oscillations measurements: 2-dimensional angular measurements (BAO2), and 3-dimensional angle-averaged measurements (BAO3). On the other hand, we consider covariance matrices, which are important tools for parameter estimation. We explore ways of compressing them by analysing their eigenvalues and signal-to-noise ratio, by employing a tomographic compression and, lastly, with the Massively Optimized Parameter Estimation and Data compression (MOPED). We find that MOPED is a powerful tool in the comparison of covariance matrices and, towards that end, we build a python code that uses a fast Monte Carlo simulation to obtain comprehensible values for differences between two covariance matrices. This method thus eliminates the need for a full cosmological analysis as we relate its output to the corresponding parameter constraints.