cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On non-supersymmetric conformal manifolds: field theory and holography
Creators: name: Bashmakov, Vladimir
name: Bertolini, Matteo
name: Raj, Himanshu
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the constraints that a conformal field theory should enjoy to admit exactly marginal deformations, i.e. to be part of a conformal manifold. In particular, using tools from conformal perturbation theory, we derive a sum rule from which one can extract restrictions on the spectrum of low spin operators and on the behavior of OPE coefficients involving nearly marginal operators. We then consider conformal field theories admitting a gravity dual description, and as such a large-$N$ expansion. We discuss the relation between conformal perturbation theory and loop expansion in the bulk, and show how such connection could help in the search for conformal manifolds beyond the planar limit. Our results do not rely on supersymmetry, and therefore apply also outside the realm of superconformal field theories.
description: 30 pages, figures. v3: discussion on contribution of graviton exchange extended + minor corrections
Traction estimation and control for mobile robots using wheel slip velocity
Creators: name: Terry, Jared D.
Publisher: name: University of Utah
Year: 2018
Subjects: Robots - Motion
Robots - Traction

description: Mobile robots are used to venture through types of environments, at low wheel speeds, where wheel slip is a threat. Wheel slip is a hazard to mobile robots in that it introduces error in dead reckoning measurement and in some instances causes the robot to halt its forward progress. To compensate for traction loss several methods are used to determine the terrain characteristics. One of these methods is Pacejka's Tire Model. The slope of Pacejka' s Tire Model can be used to determine when traction loss occurs. One step toward realizing the slope of Pacejka's Tire Model is achieving a good estimate of wheel slip. We present a unique traction estimation algorithm for low speed applications that estimates traction loss by measuring the wheel slip velocity by coupling the dynamics of a wheel with the dynamics of a vehicle. Estimates of the wheel slip velocity are accomplished using onboard sensors. To obtain an accurate estimate of the wheel slip velocity, we propose a modified Kalman Filter that fuses a system model of a DC motor with an estimate of the disturbances acting on the system model. Using the wheel slip velocity a neighborhood can be defined between two instances in time that estimates when traction loss occurs. With means of estimating traction loss, we propose a traction control law for low speed applications that provides the ability of tracking a desired reference while mitigating traction loss. To solve the tracking problem we propose a robust tracking controller that provides the ability of following a defined path and rejecting unmodeled disturbances. To mitigate traction loss we propose a continuous robust traction controller to maximize traction forces by containing wheel slip and its derivative to a neighborhood. The unique aspect of our traction controller is it works jointly with our proposed tracking controller.
Leblond, Jean, Le printemps de l'Humble esperant, aultrement dict Jehan Leblond, seigneur de Branville , ou sont comprins plusieurs petitz oeuvres semez de fleurs, fruict et verdure qu'il a composez en son jeune aage, fort recreatifz, comme on pourra veoir à la table, 1536.
Creators: name: Leblond, Jean
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Source: https://gallica.bnf.fr/ark:/12148/bpt6k70262h
description: Source: Bibliothèque nationale de France, Rés. Ye-1652
description: Relation: vignette : https://www.nakala.fr/data/11280/6684d105
Col-OSSOS: Colors of the Interstellar Planetesimal 1I/`Oumuamua
Creators: name: Bannister, Michele T.
name: Schwamb, Megan E.
name: Fraser, Wesley C.
name: Marsset, Michael
name: Fitzsimmons, Alan
name: Benecchi, Susan D.
name: Lacerda, Pedro
name: Pike, Rosemary E.
name: Kavelaars, J. J.
name: Smith, Adam B.
name: Stewart, Sunny O.
name: Wang, Shiang-Yu
name: Lehner, Matthew J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The recent discovery by Pan-STARRS1 of 1I/2017 U1 (`Oumuamua), on an unbound and hyperbolic orbit, offers a rare opportunity to explore the planetary formation processes of other stars, and the effect of the interstellar environment on a planetesimal surface. 1I/`Oumuamua's close encounter with the inner Solar System in 2017 October was a unique chance to make observations matching those used to characterize the small-body populations of our own Solar System. We present near-simultaneous g$^\prime$, r$^\prime$, and J photometry and colors of 1I/`Oumuamua from the 8.1-m Frederick C. Gillett Gemini North Telescope, and $gri$ photometry from the 4.2 m William Herschel Telescope. Our g$^\prime$r$^\prime$J observations are directly comparable to those from the high-precision Colours of the Outer Solar System Origins Survey (Col-OSSOS), which offer unique diagnostic information for distinguishing between outer Solar System surfaces. The J-band data also provide the highest signal-to-noise measurements made of 1I/`Oumuamua in the near-infrared. Substantial, correlated near-infrared and optical variability is present, with the same trend in both near-infrared and optical. Our observations are consistent with 1I/`Oumuamua rotating with a double-peaked period of $8.10 \pm 0.42$ hours and being a highly elongated body with an axial ratio of at least 5.3:1, implying that it has significant internal cohesion. The color of the first interstellar planetesimal is at the neutral end of the range of Solar System $g-r$ and $r-J$ solar-reflectance colors: it is like that of some dynamically excited objects in the Kuiper belt and the less-red Jupiter Trojans.
description: Accepted to ApJL
Dephasing representation of quantum fidelity for general pure and mixed states
Creators: name: Vanicek, Jiri
Publisher: name: arXiv
Year: 2005
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: General semiclassical expression for quantum fidelity (Loschmidt echo) of arbitrary pure and mixed states is derived. It expresses fidelity as an interference sum of dephasing trajectories weighed by the Wigner function of the initial state, and does not require that the initial state be localized in position or momentum. This general dephasing representation is special in that, counterintuitively, all of fidelity decay is due to dephasing and none due to the decay of classical overlaps. Surprising accuracy of the approximation is justified by invoking the shadowing theorem: twice--both for physical perturbations and for numerical errors. It is shown how the general expression reduces to the special forms for position and momentum states and for wave packets localized in position or momentum. The superiority of the general over the specialized forms is explained and supported by numerical tests for wave packets, non-local pure states, and for simple and random mixed states. The tests are done in non-universal regimes in mixed phase space where detailed features of fidelity are important. Although semiclassically motivated, present approach is valid for abstract systems with a finite Hilbert basis provided that the discrete Wigner transform is used. This makes the method applicable, via a phase space approach, e. g., to problems of quantum computation.
description: 11 pages, 4 figures
Translocation of Silver Through Epithelial Cell Barriers
Creators: name: Falconer, Jonathan Leslie
Publisher: name: University of Utah
Year: 2019
Subjects: Pharmaceutical sciences

description: Silver has a long history as an antimicrobial, and its use in clinical and consumer products continues to increase. Clinical silver biomaterials have achieved mixed rates of success while nanosilver consumer products in textiles, intranasal sprays, and oral liquid products are sold without significant research evaluating either safety or efficacy. Significantly, many products and research studies fail to characterize silver ion release from silver metallic coatings, compounds, and silver nanoparticles (AgNPs). Silver ion is proposed to act as the principal biologically active agent for both antibacterial activity and mammalian cell toxicity. Studies described in this dissertation seek to characterize AgNP dissolution in biological media, determine AgNP or released silver ion translocation across epithelial cells barriers, and evaluate AgNP use as a potential intranasal therapeutic to treat bacterial rhinosinusitis. First, an evaluation of the biodistribution and biocompatibility of an oral commercial colloidal silver product was performed on human subjects. Silver (not distinguishable between silver ion or AgNP forms) was detected in human blood circulation after 3-, 7-, and 14-day administrations with no adverse events reported. Next, AgNP dissolution was determined in biological media, and significant release of silver ion from AgNPs was observed. AgNP and AgNO3 translocation in human nasal epithelial cell monolayers and human ex vivo sinus tissue explants was evaluated and AgNO3 demonstrated significantly higher levels of translocation, reflecting ion preferential transport. AgNP internalization was observed in AgNP-exposed epithelial cell monolayer cultures by scanning transmission electron microscopy (STEM) and energy-dispersive x-ray spectroscopy (EDS). Finally, AgNPs were evaluated as a potential therapeutic to treat bacterial rhinosinusitis after intranasal delivery in mice. AgNO 3 demonstrated higher bactericidal activity against S. pneumoniae and significantly higher distribution of silver in the sinus tissue and blood than AgNPs. Results suggest that AgNPs would be an inadequate treatment for bacterial rhinosinusitis due to rapid clearance of silver from the sinus cavity after intranasal delivery of AgNPs. Released silver ion from AgNPs is concluded to be ostensibly responsible for all observed silver translocation through epithelium. These results are consistent with past studies that report released silver ion as the primary biologically active agent of AgNPs.
The transformation of political discourse in Egypt during Sadat's era
Creators: name: Rabinovich, Tatiana
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Middle Eastern Studies
subject: Political science
subject: FOS: Political science

description: This work traces the transformation of official political discourse in Egypt between 1971 and 1981 through official statements and written texts. Performative practices are also analyzed as locuters of discourse. Discursive shifts concern such topics as Israel, Zionism and Imperialism; state and governance; and society. Counter-discourse of radical Islamists is also analyzed through the similar lens of texts and practices. Similarities and contradictions between these two discourses regarding various aspects are explored in this research.
The Sleeping Monster: NuSTAR observations of SGR 1806-20, 11 years after the Giant Flare
Creators: name: Younes, George
name: Baring, Matthew G.
name: Kouveliotou, Chryssa
name: Harding, Alice
name: Donovan, Sophia
name: Gogus, Ersin
name: Kaspi, Victoria
name: Granot, Jonathan
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report the analysis of 5 NuSTAR observations of SGR 1806-20 spread over a year from April 2015 to April 2016, more than 11 years following its Giant Flare (GF) of 2004. The source spin frequency during the NuSTAR observations follows a linear trend with a frequency derivative $\dotν=(-1.25\pm0.03)\times10^{-12}$ Hz s$^{-1}$, implying a surface dipole equatorial magnetic field $B\approx7.7\times10^{14}$ G. Thus, SGR 1806-20 has finally returned to its historical minimum torque level measured between 1993 and 1998. The source showed strong timing noise for at least 12 years starting in 2000, with $\dotν$ increasing one order of magnitude between 2005 and 2011, following its 2004 major bursting episode and GF. SGR 1806-20 has not shown strong transient activity since 2009 and we do not find short bursts in the NuSTAR data. The pulse profile is complex with a pulsed fraction of $\sim8\%$ with no indication of energy dependence. The NuSTAR spectra are well fit with an absorbed blackbody, $kT=0.62\pm0.06$ keV, plus a power-law, $Γ=1.33\pm0.03$. We find no evidence for variability among the 5 observations, indicating that SGR 1806-20 has reached a persistent and potentially its quiescent X-ray flux level after its 2004 major bursting episode. Extrapolating the NuSTAR model to lower energies, we find that the 0.5-10 keV flux decay follows an exponential form with a characteristic timescale $τ=543\pm75$ days. Interestingly, the NuSTAR flux in this energy range is a factor of $\sim2$ weaker than the long-term average measured between 1993 and 2003, a behavior also exhibited in SGR $1900+14$. We discuss our findings in the context of the magnetar model.
description: 10 pages, 5 figures, accepted for publication in ApJ
Information-theoretic analysis of the directional influence between cellular processes
Creators: name: Lahiri, Sourabh
name: Nghe, Philippe
name: Tans, Sander J.
name: Rosinberg, Martin Luc
name: Lacoste, David
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Information Theory (cs.IT)
subject: FOS: Biological sciences
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Inferring the directionality of interactions between cellular processes is a major challenge in systems biology. Time-lagged correlations allow to discriminate between alternative models, but they still rely on assumed underlying interactions. Here, we use the transfer entropy (TE), an information-theoretic quantity that quantifies the directional influence between fluctuating variables in a model-free way. We present a theoretical approach to compute the transfer entropy, even when the noise has an extrinsic component or in the presence of feedback. We re-analyze the experimental data from Kiviet et al. (2014) where fluctuations in gene expression of metabolic enzymes and growth rate have been measured in single cells of E. coli. We confirm the formerly detected modes between growth and gene expression, while prescribing more stringent conditions on the structure of noise sources. We furthermore point out practical requirements in terms of length of time series and sampling time which must be satisfied in order to infer optimally transfer entropy from times series of fluctuations.
description: 24 pages, 7 figures
Additional file 1 of Effect of corneal refractive surgery on accommodative and binocular dysfunctions among civilian pilots in Southwest China
Creators: name: Wu, Ye
name: Zhang, Zhen
name: Liao, Meng
name: Li, Qi
name: Tang, Xue Lin
name: Liu, Longqian
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Appendix. 19-item College of Optometrists in Vision Development Quality of Life (COVD-QOL) questionnaire.
Lettre de Louis Taulèle à Jean-François Séguier, 1782-02-21
Creators: name: Taulèle, Louis
name: Taulèle, Louis
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Antiquités (général)
Epigraphie

description: [transcription] Monsieur,

J'eus l'honneur, il y a quelque temps, de vous communiquer une inscription trouvée au Mas de Gardet. Je viens d'en trouver au château de la Sauvie près de Joyeuse une seconde qui a beaucoup de rapport à la première. J'ai cru que vous seriez bien aise de la connaître. La voici, mais nous avons le malheur de n'avoir rien que de mutilé.

......................... II GAVGPEP
PROVINCIAE .......................
NONIAE SVPERIORS

Ces deux inscriptions sont bien faites pour piquer la [fol. 101 v] curiosité. La conformité du mot oniae et le rapport de Superioris et Inferioris font présumer qu'il y était question de deux portions d'une même province, mais le voisinage de ces deux pierres ne permet pas de rapporter cette idée à la Gaule narbonnaise. Vraisemblablement, cela concernait quelque division particulière à notre pays.

Nous trouvons tous les jours de nouveaux milliaires de la voie antonine. Sur le chemin de Villeneuve-de-Berg, près de Saint Germain, il y en a un bien grand, mais à peine y connait-on la trace de quelques lettres. A cinquante pas de ce milliaire, il y a un chemin pavé d'une canne de largeur qui se sépare de celui de Villeneuve et va droit à Lussas et au Coyron. Il passe bien près de ce monument dont j'ai eu l'honneur de vous parler, qui existe à Lussas sur la rive gauche d'Aiyon et qui est peut-être une de ces stations si répétées dans la carte de Peutinger.

[fol. 2 r] Près du nouveau milliaire, il y a une pierre carrée où se trouve une inscription bien formée, mais que la pluie et l'entrée de la nuit m'empêchèrent de copier. J'en ai averti Monsieur notre syndic qui ne manquera pas de le faire enlever et je ne doute point qu'elle ne contienne quelque chose de relatif à la voie romaine.

Du reste, M. de Lachadenède me prie, Monsieur, de vous faire ses excuses de ce que ses maudites affaires l'empêchèrent de se procurer l'honneur de vous voir à son retour des états. Il vous conjure de ne rien imputer à son coeur et il aura l'honneur lui-même de vous faire bientôt ses excuses.

J'ai l'honneur d'être avec un profond respect,

Monsieur,

Votre très humble et très obéissant serviteur

Taulèle

De Joyeuse, le 21 février 1782
description: [personnes citées] Paul Jean-Baptiste Charles Sabatier de Lachadenède
description: Source: [lieu de Conservation] Nîmes, Bibliothèque Carré d'Art [cote]ms. 103_3, fol. 1-2
Three-Family $SO(10)$ Grand Unification in String Theory
Creators: name: Kakushadze, Zurab
name: Tye, S. -H. Henry
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The construction of a supersymmetric $SO(10)$ grand unification with 5 left-handed and 2 right-handed families in the four-dimensional heterotic string theory is presented. The model has one $SO(10)$ adjoint Higgs field. The $SO(10)$ current algebra is realized at level 3.
description: 9 pages, Revtex 3.0, replaced with the published version (minor misprints corrected)
Transcriptional Regulation of Xenobiotic Detoxification in Drosophila
Creators: name: Misra, Jyoti Ranjan
Publisher: name: University of Utah
Year: 2019

description: Xenobiotic compounds, such as pollutants, pesticides and other foreign chemicals, represent a constant threat to the survival of all organisms. To overcome this threat, animals mount an elaborate transcriptional response, regulating a battery of genes that provide detoxification and protective functions. Proper regulation of this response is crucial as misregulation of detoxification gene expression leads to serious consequences, including resistance to cancer chemotherapy. Similarly, insects overexpressing detoxifying genes develop resistance to pesticides, which has important implications for agricultural crop protection and the control of vector borne diseases. Although much is known about how transcription factors control xenobiotic detoxification in vertebrates, we still have a limited understanding about how this response is regulated in insects. In this thesis, I describe the use of the fruit fly, Drosophila, as a simple system to define the molecular mechanisms of xenobiotic detoxification. Exposure of flies to diverse chemicals, including phenobarbital, caffeine and chlorpromazine, triggers a rapid and coordinated change in the expression of a large battery of detoxification genes, with similar time course and dose-response profiles, suggesting that a common set of transacting factors regulate this process. I showed that the CncC/Keap1 pathway plays a central role in regulating xenobiotic responses in Drosophila. Consistent with this role of CncC in detoxification gene expression, constitutive activation of the pathway provides protection against the pesticide malathion. Further, I explored the role of the CncC/Keap1 iv pathway in acquired insecticide resistance. Several field-derived and laboratory-selected insecticide resistant strains of Drosophila overexpress a number of detoxifying genes. However, the mechanisms underlying this coordinate transcriptional response remain unknown. I showed that the CncC/Keap1 pathway is constitutively active in the two DDT resistant strains of Drosophila that are currently available. I further showed that the mutation that leads to constitutive activation of the pathway is located on the third chromosome in both of these strains. Taken together, these studies identify the evolutionarily conserved CncC/Keap1 pathway as a key regulator of xenobiotic detoxification in Drosophila, define activation of this pathway as a potential mechanism for the acquisition of metabolic insecticide resistance, and provide new directions for the control of insect populations.
Unified theory of resonances and bound states in the continuum in Hermitian tight-binding models
Creators: name: Gorbatsevich, A. A.
name: Shubin, N. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study transport properties of an arbitrary two terminal Hermitian system within a tight-binding approximation and derive the expression for the transparency in the form, which enables one to determine exact energies of perfect (unity) transmittance, zero transmittance (Fano resonance) and bound state in the continuum (BIC). These energies correspond to the real roots of two energy-dependent functions that are obtained from two non-Hermitian Hamiltonians: the Feshbach's effective Hamiltonian and the auxiliary Hamiltonian, which can be easily deduced from the effective one. BICs and scattering states are deeply connected to each other. We show that transformation of a scattering state into a BIC can be formally described as a "phase transition" with divergent generalized response function. Design rules for quantum conductors and waveguides are presented, which determine structures exhibiting coalescence of both resonances and antiresonances resulting in the formation of almost rectangular transparency and reflection windows. The results can find applications in construction of molecular conductors, broad band filters, quantum heat engines and waveguides with controllable BIC formation.
description: 17 pages, 6 figures
Training a Restricted Boltzmann Machine Using Spatial Markov Random Field Priors on Weights
Creators: name: Singhal, Shweta
Publisher: name: University of Utah
Year: 2019
Subjects: Computer science

description: Recent developments have shown that restricted Boltzmann machines (RBMs) are useful in learning the features of a given dataset in an unsupervised manner. In the case of digital images, RBMs consider the image pixels as a set of real-valued random variables, disregarding their spatial layout. However, as we know, each image pixel is correlated with its neighboring pixels, and direct modeling of this correlation might help in learning. Therefore, this thesis proposes using a Markov random field prior on the weights of the RBM model, which is designed to model these correlations between neighboring pixels. We compared the test classification error of our model with that of a traditional RBM with no prior on the weights and with RBMs with L1 and L2 regularization prior on the weights. We used the NIST dataset, which consists of images of handwritten digits for our experiments.
Compressed Token Memory: Visual Encoding for Efficient LLM Inference
Creators: name: Cem, Bagdatli
Publisher: name: Zenodo
Year: 2025
Subjects: compressed token memory
Large Language Models (LLMs)
Efficient Inference
Memory Optimization
Sustainable AI Deployment
Persistent Dialogue Memory
Preprocessing Bottleneck Elimination
Language Model Scalability
AI Storage Efficiency
Compressed Token Encoding
DeepSeek Tokenizer Integration

description: This work introduces a novel token memory system that encodes transformer token sequences into 16-bit grayscale PNG images, addressing the pervasive inefficiency of repetitive dialogue history tokenization in large language models.

The proposed method achieves a 2.93-fold reduction in storage requirements compared to uncompressed text while maintaining full compatibility with the Hugging Face ecosystem.

By converting token IDs into a GPU-ready visual format, the system eliminates redundant preprocessing steps that currently consume 30-40% of inference time in conventional pipelines.

 

 

 

Zero-Copy GPU Access

Large Language Models (LLMs)

Efficient Inference

Memory Optimization

Sustainable AI Deployment

Transformer Architecture

Persistent Dialogue Memory

Preprocessing Bottleneck Elimination

Language Model Scalability

AI Storage Efficiency

Compressed Token Encoding

DeepSeek Tokenizer Integration
The Sanford Underground Research Facility
Creators: name: Heise, Jaret
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The former Homestake gold mine in Lead, South Dakota, has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering unique research opportunities in other disciplines. The Sanford Underground Research Facility (SURF) includes two main campuses at the 4850-foot level (4300 m.w.e.) -- the Davis Campus and the Ross Campus -- that host a range of significant physics projects: the LUX dark matter experiment, the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment and the CASPAR nuclear astrophysics accelerator. Furthermore, the BHUC Ross Campus laboratory dedicated to critical material assays for current and future experiments has been operating since Fall 2015. Research efforts in biology, geology and engineering have been underway at SURF for 10 years and continue to be a strong component of the SURF research program. Plans to accommodate future experiments at SURF are well advanced and include geothermal-related projects, the next generation direct-search dark matter experiment LUX-ZEPLIN (LZ) and the Fermilab-led international Deep Underground Neutrino Experiment (DUNE) at the Long Baseline Neutrino Facility (LBNF). SURF is a dedicated research facility with significant expansion capability, and applications from other experiments are welcome.
description: XV International Conference on Topics in Astroparticle and Underground Physics (TAUP 2017) 24-28 July 2017 held in Sudbury, ON Canada
15th Annual Congress of the European Society for Photodynamic Therapy in Barcelona, Spain, February 12–13th 2016
Creators: name: Braathen, Lasse R.
name: Morton, Colin A.
name: Rolf-Markus Szeimies
Publisher: name: Adis Journals
Year: 2018
Subjects: subject: Medicine
subject: 110304 Dermatology
subject: FOS: Clinical medicine

description: Article full text
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Transport of a highly lipophilic weak acid molecule (capric acid) across a lipophilic membrane between two aqueous phases in the presence of a carrier (cyclodextrins)
Creators: name: Hymas, Richard Val
Publisher: name: University of Utah
Year: 2019
Subjects: Pharmacy sciences

description: There has been a continuing need for a better quantitative understanding of the gastrointestinal absorption of highly lipophilic drugs. With this aim in mind, the present study describes a physical model approach applicable to understanding the transport of lipophilic, ionizable drugs across a lipophilic membrane. In Chapter 3, model predictions were compared to experimental results of capric acid (HA) transport across a silicone polymer membrane in the presence and in the absence of 2-hydroxypropyl-β-cyclodextrin (HPB). Model predictions and experimental results were generally in agreement over the entire studied ranges of pH and HPB concentrations. In Chapter 4, the physical model approach was then applied to the in situ single pass perfusion system involving the rat ileum to obtain a more detailed understanding about cyclodextrin as an intestinal drug absorption enhancer through its role as a carrier. Model predictions were found to be generally in good agreement with experimental results. We also extended this model to account for the villus structure of the small intestine, resulting in equally good agreement. Both models demonstrated that HPB was able to reduce the capric acid concentration gradient across the aqueous boundary layer and increase the effective intestinal membrane surface area utilized for permeant absorption due to deeper penetration of the permeant into the villus crypts, accounting for the HPB-enhanced permeant flux. In an exploratory investigation (Chapter 5), the in situ single pass perfusion technique was then used to examine the ability of two well known chemical permeation enhancers of hydrophilic drug molecules, sodium caprate (HA) and sodium chenodeoxycholate (CDC), to enhance mannitol transport in the rat ileum in the presence and absence of different cyclodextrin carriers. Analysis of the experimental results with the villus model (VM) support the interpretation that an appropriate enhancer/carrier combination may (1) be able to increase the fraction of ileum surface area that is enhanced and, because of this, that (2) local toxicity effects of the enhancer might be avoided or reduced for any given mannitol permeability enhancement, while (3) at the same time provide increased enhancer duration of action.
Neutrosophic EOQ Model with Price Break
Creators: name: M. Mullai
name: R. Surya
Publisher: name: figshare
Year: 2018
Subjects: Algebra

description: Inventory control of an ideal resource is the most important one which fulfils various activities (functions) of an organisation. The supplier gives the discount for an item in the cost of units inorder to motivate the buyers (or) customers to purchase the large quantity of that item.
Towards a global quantum network
Creators: name: Simon, Christoph
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The creation of a global quantum network is within reach combining satellite links and quantum memory based approaches. Applications will range from secure communication and fundamental physics experiments to a future quantum internet.
description: 4 pages, 1 figure, commentary for Nature Photonics, unedited version
Ergodic theory of accessible partially hyperbolic endomorphisms
Creators: name: Tyler, Audrey
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 490412
subject: Topology
classificationCode: 490499
subject: Pure mathematics not elsewhere classified

description: In 1995 at the International Conference on Dynamical Systems a conjecture was posed. That among invertible partially hyperbolic systems ergodicity was the general case. But not all dynamical systems are invertible, a system is non-invertible when different past states lead to the same future state.
Non-invertible partially hyperbolic systems are the object of our study. To obtain our main result we first had to carefully study the current theory of invertible partially hyperbolic systems. By adapting these techniques to the non-invertible setting, we show what are sufficient conditions for ergodicity.
On the shape of the UHE cosmic ray spectrum
Creators: name: De Marco, Daniel
name: Stanev, Todor
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We fit the ultra high energy cosmic ray spectra above 10$^{19}$ eV with different injection spectra at cosmic ray sources that are uniformly and homogeneously distributed in the Universe. We conclude that the current UHE spectra are consistent with power laws of index $α$ between 2.4 and 2.7. There is a slow dependence of these indices on the cosmological evolution of the cosmic ray sources, which in this model determines the end of the galactic cosmic rays spectrum.
description: 5 pages, version accepted in PRD
Additional file 2 of Similarity and diversity of genetic architecture for complex traits between East Asian and European populations
Creators: name: Zhang, Jinhui
name: Zhang, Shuo
name: Qiao, Jiahao
name: Wang, Ting
name: Zeng, Ping
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2
أثر بعض الاستراتيجيات إدارة الموارد البشرية في تحسين أداء المؤسسات الرياضية The impact of some strategies for human resource management in improfing the performance of sports institutions
Creators: name: عبد الحليم, العياضي
name: أحمد, بن محمد
Publisher: name: Zenodo
Year: 2022
Subjects: Strategy, Human Resource managment, Performance, Sports Institution

description: The Object of the study aims to identify the extent of the impact of some strategies for human resources in achieving the efficiency of the perfomance of the sports institution, for this purpose, we used the method descriptive analytical On a sample composed of 150 administrators in mult-sports offices and youth institutions Chosen as simple random, and for data collection, we used the questionnaire tool, After collecting the results and having treated them statistically, we conclude that there is an effect of some strategies (selection, appointment) for human resources in improving the performance of sports institutions to a high degree. On this basis, the study recommended working with technology and digitizing everything related to the sector to facilitate the task of managing human resources, and the need to involve executives in the selection processes of employees
Resolving Singularities in (0,2) Models
Creators: name: Distler, J.
name: Greene, B.
name: Morrison, D.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In contrast to the familiar (2,2) case, the singularities which arise in the (0,2) setting can be associated with degeneration of the base Calabi-Yau manifold {\it and/or}\/ with degenerations of the gauge bundle. We study a variety of such singularities and give a procedure for resolving those which can be cured perturbatively. Among the novel features which emerge are models in which smoothing singularities in the base yields a gauge {\it sheaf}\/ as opposed to a gauge bundle as the structure to which left moving fermions couple. Supersymmetric $σ$-models with target data being an appropriate sheaf on a Calabi-Yau space therefore appear to be the natural arena for N=1 string models in four dimensions. We also indicate a variety of singularities which would require a nonperturbative treatment for their resolution and briefly discuss applications to heterotic models on K3.
description: 33 pages, harvmac
Gravitational lensing time delays with massive photons
Creators: name: Glicenstein, J-F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: This paper investigates the use of gravitational time delays of macro-lenses to constrain a possible photon mass. The time delay between the 2 compact images of a source of massive photons is computed. Explicit expressions are given for Schwarzschild and singular isothermal lenses. In the latter case, the time delay is very insensitive to the photon mass. Modeling lens galaxies by a singular isothermal model and a central supermassive black hole, the photon mass-dependent part of the time delay between the compact images is shown to be proportional to the mass of the black hole. The sensitivity of time delays to the photon mass is illustrated by a bound obtained from 3 AGN which have measurements in several passbands. The bound obtained is comparable to the limit with the deflection of radio waves by the Sun.
description: 10 pages, Accepted for publication in ApJ
Long-distance frequency dissemination with a resolution of 10-17
Creators: name: Daussy, Christophe
name: Lopez, Olivier
name: Amy-Klein, Anne
name: Goncharov, Andréi N.
name: Guinet, Mickael
name: Chardonnet, Christian
name: Narbonneau, François
name: Lours, Michel
name: Chambon, Damien
name: Bize, Sébastien
name: Clairon, André
name: Santarelli, Georgio
name: Tobar, Mike E.
name: Luiten, Andre N.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We use a new technique to disseminate microwave reference signals along ordinary optical fiber. The fractional frequency resolution of a link of 86 km in length is 10-17 for a one day integration time, a resolution higher than the stability of the best microwave or optical clocks. We use the link to compare the microwave reference and a CO2/OsO4 frequency standard that stabilizes a femtosecond laser frequency comb. This demonstrates a resolution of 3.10-14 at 1 s. An upper value of the instability introduced by the femtosecond laser-based synthesizer is estimated as 1.10-14 at 1 s.
Observations of Mkn 421 in 2004 with H.E.S.S. at large zenith angles
Creators: name: Collaboration, H. E. S. S.
name: :
name: Aharonian, F.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Mkn 421 was observed during a high flux state for nine nights in April and May 2004 with the fully operational High Energy Stereoscopic System (H.E.S.S.) in Namibia. The observations were carried out at zenith angles of 60$^\circ$--65$^\circ$, which result in an average energy threshold of 1.5 TeV and a collection area reaching 2~km$^2$ at 10~TeV. Roughly 7000 photons from Mkn~421 were accumulated with an average gamma-ray rate of 8 photons/min. The overall significance of the detection exceeds 100 standard deviations. The light-curve of integrated fluxes above 2~TeV shows changes of the diurnal flux up to a factor of 4.3. For nights of high flux, intra-night variability is detected with a decay time of less than 1 hour. The time averaged energy spectrum is curved and is well described by a power-law with a photon index $\egamm$ and an exponential cutoff at $\ecut$~TeV and an average integral flux above 2~TeV of 3 Crab flux units. Significant variations of the spectral shape are detected with a spectral hardening as the flux increases. Contemporaneous multi-wavelength observations at lower energies (X-rays and gamma-rays above $\approx 300$~GeV) indicate smaller relative variability amplitudes than seen above 2~TeV during high flux state observed in April 2004.
description: 5 pages, 4 figures, published in A&A
Dynamical Casimir effect in stochastic systems: photon-harvesting through noise
Creators: name: Román-Ancheyta, R.
name: Ramos-Prieto, I.
name: Perez-Leija, A.
name: Busch, K.
name: León-Montiel, R. de J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We theoretically investigate the dynamical Casimir effect in a single-mode cavity endowed with a driven off-resonant mirror. We explore the dynamics of photon generation as a function of the ratio between the cavity mode and the mirror's driving frequency. Interestingly, we find that this ratio defines a threshold---which we referred to as a metal-insulator phase transition---between an exponential growth and a low photon production. The low photon production is due to Bloch-like oscillations that produce a strong localization of the initial vacuum state, thus preventing higher generation of photons. To break localization of the vacuum state, and enhance the photon generation, we impose a dephasing mechanism, based on dynamic disorder, into the driving frequency of the mirror. Additionally, we explore the effects of finite temperature on the photon production. Concurrently, we propose a classical analogue of the dynamical Casimir effect in engineered photonic lattices, where the propagation of classical light emulates the photon generation from the quantum vacuum of a single-mode tunable cavity.
The target space geometry of N=(2,1) string theory
Creators: name: Lawrence, Albion
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe the ${\cal{O}}({α'}^0)$ constraints on the target space geometry of the $N=(2,1)$ heterotic superstring due to the left-moving $N=1$ supersymmetry and $U(1)$ currents. In the fermionic description of the internal sector supersymmetry is realized quantum mechanically, so that both tree-level and one-loop effects contribute to the order ${\cal{O}}({α'}^0)$ constraints. We also discuss the physical interpretation of the resulting target space geometry in terms of configurations of a $2+2$-dimensional object propagating in a $10+2$-dimensional spacetime with a null isometry, which has recently been suggested as a unified description of string and M theory.
description: 41 pages, 5 figures, standard LaTeX, uses epsf.tex. Some typos corrected, discussion in footnote 1 corrected
ФОРМИРОВАНИЕ УУД МЕТАСУГБЕСТ НА УРОКАХ МАТЕМАТИИ В СРЕДНЕЙ ОБРАЗОВАТЕЛЬНОЙ ШКОЛЕ
Creators: name: Сапарова, Айзада
Publisher: name: Zenodo
Year: 2024

description: В статье рассматриваются вопросы, связанные с проблемой формирования универсальных учебных действий с использованием различных средств, в том числе метапредметных характеристик, в условиях государственных образовательных стандартов.
title: Visibilizando lo Invisible: Adolescencia, bienestar e imagen corporal el rol de la familia
title: Imágenes, palabras y miradas  que moldean los cuerpos y  las mentes en la adolescencia
titleType: AlternativeTitle
Creators: name: Calado Otero, María
Publisher: name: Zenodo
Year: 2025

description: Este taller explora el impacto de los mensajes socioculturales en la construcción de la imagen corporal durante la adolescencia, destacando el rol fundamental de las familias en la prevención de la insatisfacción corporal y los trastornos alimentarios. A través de un enfoque feminista y no pesocentrista, se ofrecen pautas para crear entornos protectores que promuevan una relación saludable con el cuerpo y el bienestar integral de las adolescentes. El contenido analiza cómo los comentarios tempranos sobre el cuerpo, los estereotipos sexistas y el estigma del peso se interiorizan, afectando la autoestima, la vida social y emocional de las jóvenes. Además, se presentan herramientas prácticas para las familias, como la promoción de la autoestima, el cuestionamiento de mensajes de los medios y la búsqueda de ayuda profesional ante señales de alerta. El taller forma parte del Proyecto "Visibilizando lo Invisible", centrado en la igualdad de género y la prevención de la violencia simbólica.
On the cosmological gravitational waves and cosmological distances
Creators: name: Belinski, V. A.
name: Vereshchagin, G. V.
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that solitonic cosmological gravitational waves propagated through the Friedmann universe and generated by the inhomogeneities of the gravitational field near the Big Bang can be responsible for increase of cosmological distances.
Additional file 5 of HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis
Creators: name: Li, Ke
name: Gong, Quan
name: Xiang, Xu-Dong
name: Guo, Gang
name: Liu, Jia
name: Zhao, Li
name: Li, Jun
name: Chen, Nan
name: Li, Heng
name: Zhang, Li-Juan
name: Zhou, Chun-Yan
name: Wang, Zhi-Yong
name: Zhuang, Li
Publisher: name: figshare
Year: 2023
Subjects: Biophysics
Biochemistry
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: Additional file 5: Table S1. The sequences of the primers. Table S2. The association of HNRNPA2B1 expression with clinicopathological characteristics of LAC patients. Table S3. Cox regression analysis of HNRNPA2B1 expression as survival predictor. Table S4. The correlation of MEG3 expression with clinicopathologic characteristics of LAC patients. Table S5. The association of miR-21-5p expression with clinicopathological characteristics of LAC patients. Table S6. Cox regression analysis of miR-21-5p expression as survival predictor.
Towards a Fast NVMe Layer for a Decomposed Kernel
Creators: name: Balasubramanian, Abhiram
Publisher: name: University of Utah
Year: 2019
Subjects: Computer science

description: Operating system (OS) kernel extensions, particularly device drivers, are one of the primary sources of vulnerabilities in commodity OS kernels. Vulnerabilities in driver code are often exploited by attackers, leading to attacks like privilege escalation, denial-of-service, and arbitrary code execution. Today, kernel extensions are fully trusted and operate within the core kernel without any form of isolation. But history suggests that this trust is often misplaced, emphasizing a need for some isolation in the kernel. We develop a new framework for isolating device drivers in the Linux kernel. Our work builds on three fundamental principles: (1) strong isolation of the driver code; (2) reuse of existing driver while making no or minimal changes to the source; and (3) achieving same or better performance compared to the nonisolated driver. In comparison to existing driver isolation schemes like driver virtual machines and user-level device driver implementations, our work strives to avoid modifying existing code and implements an I/O path without incurring substantial performance overhead. We demonstrate our approach by isolating a unmodified driver for a null block device in the Linux kernel, achieving near-native throughput for block sizes ranging from 512B to 256KB and outperforming the nonisolated driver for block sizes of 1MB and higher.