cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epstein-Barr Virus Latent Membrane Protein-1 Effects on Junctional Plakoglobin and Induction of a Cadherin Switch
Creators: name: Raab-Traub, Nancy
name: Shair, Kathy H.Y.
name: Schnegg, Caroline I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Latent membrane protein-1 (LMP1) is considered the major oncoprotein of Epstein-Barr virus (EBV) and is frequently expressed in nasopharyngeal carcinoma (NPC). LMP1 promotes growth and migration of epithelial cells, and the loss of plakoglobin has been identified as a contributing factor to LMP1-induced migration. Plakoglobin is a junctional protein that can also serve as a transcription factor in Tcf/Lef signaling. To determine the effects of LMP1 on the molecular and functional properties of plakoglobin, LMP1 was over-expressed in the NPC cell line, C666-1. LMP1 did not affect plakoglobin stability but did decrease plakoglobin transcription. The resultant decreased levels of nuclear plakoglobin did not affect Tcf/Lef activity or the amount of plakoglobin bound to Tcf4. Although LMP1 induced and stabilized β-catenin, a protein with common binding partners to plakoglobin, the loss of plakoglobin did not affect its association with Tcf4. However LMP1 did induce a cadherin switch from E- to N-cadherin, a process involved in cancer progression, and enhanced the association of junctional β-catenin with N-cadherin. LMP1 decreased overall levels of junctional plakoglobin but the remaining junctional plakoglobin was found associated with the induced N-cadherin. This increased association of junctional plakoglobin with N-cadherin was a distinguishing feature of LMP1-expressing cells that have reduced migration due to restoration of plakoglobin. Low levels of plakoglobin were also detected in human NPC tissues. These findings reveal that the effects of LMP1 on junctional plakoglobin and the initiation of a cadherin switch likely contribute to metastasis of NPC.
Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer
Creators: name: Knudsen, Karen E.
name: Weissman, Bernard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10-12 unique subunits. While the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease.
title: Missed fractures in AE two-point audit
Creators: name: Awad Alkareem, Mohamed
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Plain radiographic studies
subject: Audit and standards
subject: Acute

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To dettermine the frequency of missed fracutres in AE (false negatives). To determine the type and locations of fractures missed in AE. False postives are less likely to be detrimental to patients so not examined in this...
Modelo para Caracterização e Evolução de Sistemas com Arquitetura Baseada em Serviços
Creators: name: Rosa, Thatiane de Oliveira
name: Goldman, Alfredo
name: Guerra, Eduardo Martins
Publisher: name: Zenodo
Year: 2020
Subjects: Arquitetura de software
Sistemas baseados em serviços
Microsserviços
Modelo para caracterização e evolução

description: Construir uma boa arquitetura é fundamental para obter sucesso no processo de desenvolvimento de software. Porém, essa não é uma atividade trivial, pois envolve uma série de decisões de domínio do negócio, técnicas e de estrutura. Assim, com a finalidade de apoiar a construção de uma arquitetura mais adequada a um determinado contexto, constantemente surgem novas abordagens como microsserviços e monolitos modulares, que propõem decompor um software complexo em pequenas partes fracamente acopladas. Entretanto, ao analisar o estado da arte e da prática, percebe-se que existe um limite nebuloso na classificação dessas diferentes abordagens, especialmente as baseadas em serviços. Além de existir pouco suporte para caracterizar e direcionar arquiteturas baseadas em serviços. Diante disso, com base em pesquisas bibliográficas e estudos de caso, pretende-se desenvolver um modelo para caracterização e evolução da arquitetura de sistemas baseados em serviços, adotando diretrizes de microsserviços. Esse modelo apresenta dimensões que medem características estruturais da arquitetura relacionadas ao tamanho de módulos, compartilhamento de bases de dados e acoplamento entre serviços. Como contribuição final, esse modelo facilitará o mapeamento e medição de diferentes impactos gerados na arquitetura de software, a partir de incrementos e refatorações realizados. Assim como dará suporte a decisões arquiteturais que considerem diferentes atributos de qualidade para alcançar o equilíbrio entre independência e colaboração de serviços para um determinado sistema.
description: Trabalho aceito para apresentação no Workshop de Teses e Dissertações do CBSoft 2020 - Thatiane de Oliveira Rosa
title: A pictorial review of radiological-pathological discordant cases after percutaneous breast needle biopsies
Creators: name: Nasute Fauerbach, Paola
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Biopsy
subject: Diagnostic procedure
subject: Education
subject: Cancer
subject: Education and training
subject: Quality assurance

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: 1. To illustrate mammographic, sonographic, and MRI findings that should raise concern for lack of concordance with pathological results after a percutaneous core needle biopsy (CNB) 2. To review the importance of including patients’ clinical...
Modeling of Speech-dependent Own Voice Transfer Characteristics for Hearables with In-ear Microphones
Creators: name: Ohlenbusch, Mattes
name: Rollwage, Christian
name: Doclo, Simon
Publisher: name: arXiv
Year: 2023
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Many hearables contain an in-ear microphone, which may be used to capture the own voice of its user. However, due to the hearable occluding the ear canal, the in-ear microphone mostly records body-conducted speech, typically suffering from band-limitation effects and amplification at low frequencies. Since the occlusion effect is determined by the ratio between the air-conducted and body-conducted components of own voice, the own voice transfer characteristics between the outer face of the hearable and the in-ear microphone depend on the speech content and the individual talker. In this paper, we propose a speech-dependent model of the own voice transfer characteristics based on phoneme recognition, assuming a linear time-invariant relative transfer function for each phoneme. We consider both individual models as well as models averaged over several talkers. Experimental results based on recordings with a prototype hearable show that the proposed speech-dependent model enables to simulate in-ear signals more accurately than a speech-independent model in terms of technical measures, especially under utterance mismatch and talker mismatch. Additionally, simulation results show that talker-averaged models generalize better to different talkers than individual models.
description: 20 pages, 11 figures; Extended version of arXiv:2309.08294 (more detailed description of the problem, additional models considered, more systematic evaluation conducted on a different, larger dataset) -> Updated version (20th march 2024): major changes after internal review; in submission
title: Calcifications with suspicious morphology: CESM findings and radiologic-pathologic correlation
Creators: name: Calvo Gijón, Daniel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: Diagnostic procedure
subject: Calcifications / Calculi
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To describe the most common contrast-enhanced spectral mammography (CESM) features of calcifications with suspicious morphology (BI-RADS ≥ 4) in comparison with the final diagnosis. To compare the lesion characteristics based on CESM with the...
Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis
Creators: name: O'Quinn, Ryan
name: Schliekelman, Mark
name: Oliver, Trudy G.
name: Salmon, E. D.
name: Van Dyke, Terry
name: Cowley, Dale O.
name: Lu, Cy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in mice cause embryonic lethality. We produced mice harboring a Bub1 mutant allele lacking exons 2 and 3, resulting in a hypomorphic mutant expressed at <5% of wild-type levels. Despite this significant reduction, homozygous mutant animals are viable on a mixed 129P2/B6 or FVB background but display increased tumorigenesis with aging, whereas mice with a C57Bl/6J background die perinatally. Bub1 mutant murine embryonic fibroblasts (MEFs) display defects in chromosome congression to the metaphase plate, severe chromosome missegregation, and aneuploidy accompanied by high levels of premature senescence. Mutant MEFs have a robust SAC in response to nocodazole treatment but an impaired response to Taxol. Mutant MEFs also show reduced kinetochore localization of BubR1, but not of Mad2. The significant reduction in SAC response to Taxol, but not nocodazole, coupled with the reduced binding of BubR1, but not Mad2, indicates that Bub1 is particularly critical for the SAC response to a lack of tension on kinetochores. Thus, Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
(401779) Angelica Chisholm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Proyecto VIRTIGATION Hoja de Hechos
Creators: name: RTDS Group
name: AGAPA
Publisher: name: Zenodo
Year: 2022

description: Este hoja de hechos fue creado por RTDS Group y AGAPA como socios del proyecto VIRTIGATION - Enfermedades víricas emergentes en tomates y cucurbitáceas: aplicación de estrategias de mitigación para la gestión sostenible de enfermedades. Este proyecto ha recibido financiación del programa de investigación e innovación H2020 de la Unión Europea bajo el Acuerdo de Subvención número 101000570.
A data transfer agreement template for South Africa
Creators: name: Swales, Lee
name: Ogendi, Paul
name: Botes, Marietjie
name: Townsend, Beverley
name: Donnelly, Dusty-Lee
name: Abdulrauf, Lukman
name: Thaldar, Donrich
Publisher: name: Zenodo
Year: 2023
Subjects: DTA
POPIA
South Africa

description: This is version 1.0 of a data transfer agreement (DTA) for use by the South African research community, together with an explanatory memorandum.
description: Comments can be submitted to healthlaw@ukzn.ac.za
Event-chain algorithm for the Heisenberg model: Evidence for $z \simeq 1$ dynamic scaling
Creators: name: Nishikawa, Yoshihiko
name: Michel, Manon
name: Krauth, Werner
name: Hukushima, Koji
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We apply the event-chain Monte Carlo algorithm to the three-dimensional ferromagnetic Heisenberg model. The algorithm is rejection-free and also realizes an irreversible Markov chain that satisfies global balance. The autocorrelation functions of the magnetic susceptibility and the energy indicate a dynamical critical exponent $z \approx 1$ at the critical temperature, while that of the magnetization does not measure the performance of the algorithm. This seems to be the first report that the event-chain Monte Carlo algorithm substantially reduces the dynamical critical exponent from the conventional value of $z\simeq 2$.
description: 4 pages, 5 figures
title: Bloody hell: who is the bleeder?
Creators: name: Cayón Somacarrera, Silvia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Interventional vascular
subject: Pelvis
subject: Vascular
subject: Catheter arteriography
subject: CT
subject: Ultrasound-Colour Doppler
subject: Arterial access
subject: Catheters
subject: Embolisation
subject: Blood
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aim of this work is to give easy tips to determine on CT the most probable bleeding artery in pelvic hemorraghes based upon a map which shows an approximation of the zonal pelvic...
Excitation functions of proton-induced reactions on natural Nd and production of radionuclides relevant for double beta decay: Completing measurement in 5-35 MeV energy range
Creators: name: Lebeda, O.
name: Lozza, V.
name: Petzoldt, J.
name: Stursa, J.
name: Zdychova, V.
name: Zuber, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Cross-sections for the proton-induced reactions on natural neodymium in energy regions 5-10 MeV and 30-35 MeV were measured using the cyclotron U-120M at the Nuclear Physics Institute at Rez near Prague. This measurement completes the investigation previously done in the 10-30 MeV energy range. Results revealed practical production thresholds and secondary maxima and minima in the excitation functions. It allowed for more appropriate calculation of thick target yields and production rates of many longer-lived radionuclides potentially disturbing the search for neutrinoless double beta decay. Measured cross-sections are consistent with our previously published data.
Molecular Dosimetry of 1,2,3,4-Diepoxybutane-Induced DNA-DNA Cross-Links in B6C3F1 Mice and F344 Rats Exposed to 1,3-Butadiene by Inhalation
Creators: name: Walker, Vernon E.
name: Swenberg, James A.
name: Tretyakova, Natalia
name: Goggin, Melissa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: 1,3-butadiene (BD) is an important industrial and environmental chemical classified as a human carcinogen based on epidemiological studies in occupationally exposed workers and animal studies in laboratory rats and mice. BD is metabolically activated to three epoxides that can react with nucleophilic sites in biomolecules. Among these, 1,2,3,4-diepoxybutane (DEB) is considered the ultimate carcinogen due to its high genotoxicity and mutagenicity attributed to its ability to form DNA-DNA crosslinks. Our laboratory has developed quantitative HPLC-µESI+-MS/MS methods for two DEB-specific DNA-DNA cross-links, 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) and 1-(guan-7-yl)-4-(aden-1-yl)-2,3-butanediol (N7G-N1A-BD). This report describes molecular dosimetry analysis of these adducts in tissues of B6C3F1 mice and F344 rats exposed to a range of BD concentrations (0–625 ppm). Much higher (4–10-fold) levels of DEB-DNA cross-links were observed in mice as compared to rats exposed to the same BD concentrations. In both species, bis-N7G-BD levels were 1.5–4 fold higher in the liver than in other tissues examined. Interestingly, tissues of female animals exposed to BD contained higher concentrations of bis-N7G-BD adducts than tissues of male animals, which is in accord with previously reported differences in tumor incidence. The molecular dosimetry data presented herein suggests that species and gender differences observed in BD-induced cancer are directly related to differences in the extent of BD metabolism to DEB. Furthermore, a rat model of sensitivity to BD may be more appropriate than a mouse model for assessing human risk associated with BD exposure, since rats and humans appear to be similar in respect to DEB formation.
title: Pelvic Paget and differential diagnosis: what radiologists need to know
Creators: name: Di Mari, Alessia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: CT
subject: Digital radiography
subject: MR
subject: Diagnostic procedure
subject: Education
subject: Metabolic disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Pelvic Paget’s disease (PD) can mimic neoplastic and non-neoplastic disease that involve frequently the pelvis in the older age. The goal of this work is describing the radiological typical features of pelvic Paget and helping the radiologists in...
A Dark Census: Statistically Detecting the Satellite Populations of Distant Galaxies
Creators: name: Cyr-Racine, Francis-Yan
name: Moustakas, Leonidas A.
name: Keeton, Charles R.
name: Sigurdson, Kris
name: Gilman, Daniel A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In the standard structure formation scenario based on the cold dark matter paradigm, galactic halos are predicted to contain a large population of dark matter subhalos. While the most massive members of the subhalo population can appear as luminous satellites and be detected in optical surveys, establishing the existence of the low mass and mostly dark subhalos has proven to be a daunting task. Galaxy-scale strong gravitational lenses have been successfully used to study mass substructures lying close to lensed images of bright background sources. However, in typical galaxy-scale lenses, the strong lensing region only covers a small projected area of the lens's dark matter halo, implying that the vast majority of subhalos cannot be directly detected in lensing observations. In this paper, we point out that this large population of dark satellites can collectively affect gravitational lensing observables, hence possibly allowing their statistical detection. Focusing on the region of the galactic halo outside the strong lensing area, we compute from first principles the statistical properties of perturbations to the gravitational time delay and position of lensed images in the presence of a mass substructure population. We find that in the standard cosmological scenario, the statistics of these lensing observables are well approximated by Gaussian distributions. The formalism developed as part of this calculation is very general and can be applied to any halo geometry and choice of subhalo mass function. Our results significantly reduce the computational cost of including a large substructure population in lens models and enable the use of Bayesian inference techniques to detect and characterize the distributed satellite population of distant lens galaxies.
description: 21 pages + appendices, 7 figures. v2: Some derivations streamlined, extended appendices. Matches version published in PRD
Valuations and Frobenius
Creators: name: Datta, Rankeya
name: Smith, Karen E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13A35, 13F30, 14B05

description: The behavior of the Frobenius map is investigated for valuation rings of prime characteristic. We show that valuation rings are always F-pure. We introduce a generalization of the notion of strong F-regularity, which we call F-pure regularity, and show that a valuation ring is F-pure regular if and only if it is Noetherian. For valuations on function fields, we show that the Frobenius map is finite if and only if the valuation is divisorial; in this case the valuation ring is Frobenius split. For Noetherian valuation rings in function fields, we show that the valuation ring is Frobenius split if and only if Frobenius is finite, or equivalently, if and only if the valuation ring is excellent.
description: An Erratum has been added correcting Theorem 5.1 on the equivalence of F-finite and Abhyankar valuations. Comments are welcome
PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer
Creators: name: Phommaly, Chanpheng
name: Crowder, Robert J.
name: Hoog, Jeremy
name: Perou, Charles M.
name: Snider, Jacqueline
name: Olson Jr., John A.
name: Miller, Melinda A.
name: Davies, Sherri R.
name: Tao, Yu
name: Parker, Joel S.
name: Lin, Li
name: Luo, Jingqin
name: Weber, Jason D.
name: Watson, Mark A.
name: Huntsman, David G.
name: Saporita, Anthony
name: Ellis, Matthew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Several phosphoinositide-3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between pharmacological inhibition and somatic mutations in PI3K catalytic subunits in ER+ breast cancer, where these mutations are particularly common. RNA interference (RNAi) was used to determine the effect of selective inhibition of PI3K catalytic subunits, p110α and p110β, in ER+ breast cancer cells harboring either mutation (PIK3CA) or gene amplification (PIK3CB). p110α RNAi inhibited growth and promoted apoptosis in all tested ER+ breast cancer cells under estrogen deprived-conditions, whereas p110β RNAi only affected cells harboring PIK3CB amplification. Moreover, dual p110α/p110β inhibition potentiated these effects. In addition, treatment with the clinical grade PI3K catalytic subunit inhibitor BEZ235 also promoted apoptosis in ER+ breast cancer cells. Importantly, estradiol suppressed apoptosis induced by both gene knockdowns and by BEZ235 treatment. Our results suggest that PI3K inhibitors should target both p110α and p110β catalytic subunits, whether wild-type or mutant, and be combined with endocrine therapy for maximal efficacy when treating ER+ breast cancer.
Theory of tunneling conductance of anomalous Rashba metal / superconductor junctions
Creators: name: Fukumoto, Toshiyuki
name: Taguchi, Katsuhisa
name: Kobayashi, Shingo
name: Tanaka, Yukio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically study the charge conductance in anomalous Rashba metal (ARM)/superconductor junctions for various types of the pairing symmetries in the superconductor. The exotic state dubbed ARM, where one of the spin resolved Fermi surface is absent, is realized when the chemical potential is tuned both in the presence of Rashba spin-orbit interaction (RSOI) and an exchange field. Although a fully polarized ferromagnet metal (FPFM) is also a system where the electron's spin degrees of a freedom is reduced to be half, the electrons in an ARM have distinct features from those in FPFM. For the ARM/spin-singlet superconductor junctions, the obtained tunneling conductance within the bulk energy gap is enhanced with the increase in the magnitude of the RSOI. In particular, in ARM/$d_{xy}$-wave superconductor junctions, the zero bias conductance peak is enhanced owing to the presence of the RSOI. For ARM/$p_{x}$-wave superconductor junctions, the condition of the existence of the zero bias conductance peak is significantly sensitive to the direction of the d-vector of the $p_{x}$-wave superconductor. Furthermore, the obtained conductance in ARM/chiral $p$-wave superconductor junctions shows different behaviors as compared to those in ARM/helical $p$-wave superconductor junctions. This feature gives a guide to determine the spin structure of the Cooper pair in spin-triplet superconductor Sr$_{2}$RuO$_{4}$.
description: 18 pages, 18 figures, 1 table
MQT Predictor: Automatic Device Selection with Device-Specific Circuit Compilation for Quantum Computing
Creators: name: Quetschlich, Nils
name: Burgholzer, Lukas
name: Wille, Robert
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Fueled by recent accomplishments in quantum computing hardware and software, an increasing number of problems from various application domains are being explored as potential use cases for this new technology. Similarly to classical computing, realizing an application on a particular quantum device requires the corresponding (quantum) circuit to be compiled so that it can be executed on the device. With a steadily growing number of available devices and a wide variety of different compilation tools, the number of choices to consider when trying to realize an application is quickly exploding. Due to missing tool support and automation, especially end-users who are not quantum computing experts are easily left unsupported and overwhelmed. In this work, we propose a methodology that allows one to automatically select a suitable quantum device for a particular application and provides an optimized compiler for the selected device. The resulting framework -- called the MQT Predictor -- not only supports end-users in navigating the vast landscape of choices, it also allows mixing and matching compiler passes from various tools to create optimized compilers that transcend the individual tools. Evaluations of an exemplary framework instantiation based on more than 500 quantum circuits and seven devices have shown that -- compared to both Qiskit's and TKET's most optimized compilation flows for all devices -- the MQT Predictor produces circuits within the top-3 out of 14 baselines in more than 98% of cases while frequently outperforming any tested combination by up to 53% when optimizing for expected fidelity. MQT Predictor is publicly available as open-source on GitHub (https://github.com/cda-tum/mqt-predictor) and as an easy-to-use Python package (https://pypi.org/p/mqt.predictor).
description: 25 pages, 11 figures, minor adjustments, published in the ACM Transactions on Quantum Computing (TQC)
MarMot: Metamorphic Runtime Monitoring of Autonomous Driving Systems
Creators: name: Ayerdi, Jon
name: Iriarte, Asier
name: Valle, Pablo
name: Roman, Ibai
name: Illarramendi, Miren
name: Arrieta, Aitor
Publisher: name: arXiv
Year: 2023
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Autonomous Driving Systems (ADSs) are complex Cyber-Physical Systems (CPSs) that must ensure safety even in uncertain conditions. Modern ADSs often employ Deep Neural Networks (DNNs), which may not produce correct results in every possible driving scenario. Thus, an approach to estimate the confidence of an ADS at runtime is necessary to prevent potentially dangerous situations. In this paper we propose MarMot, an online monitoring approach for ADSs based on Metamorphic Relations (MRs), which are properties of a system that hold among multiple inputs and the corresponding outputs. Using domain-specific MRs, MarMot estimates the uncertainty of the ADS at runtime, allowing the identification of anomalous situations that are likely to cause a faulty behavior of the ADS, such as driving off the road.
 We perform an empirical assessment of MarMot with five different MRs, using two different subject ADSs, including a small-scale physical ADS and a simulated ADS. Our evaluation encompasses the identification of both external anomalies, e.g., fog, as well as internal anomalies, e.g., faulty DNNs due to mislabeled training data. Our results show that MarMot can identify up to 65\% of the external anomalies and 100\% of the internal anomalies in the physical ADS, and up to 54\% of the external anomalies and 88\% of the internal anomalies in the simulated ADS. With these results, MarMot outperforms or is comparable to other state-of-the-art approaches, including SelfOracle, Ensemble, and MC Dropout-based ADS monitors.
description: Accepted at ACM Transactions on Software Engineering and Methodology
A Metadata Handling API for Framework Development: a Comparative Study
Creators: name: Guerra, Eduardo
Publisher: name: Zenodo
Year: 2020

description: Frameworks play an essential role in software development, providing not only code reuse, but also design reuse. Several Java frameworks and APIs such as Spring, JPA, and CDI rely on the use of metadata, mainly defined by code annotations. These frameworks usually use the Java Reflection API to consume code annotations, which only returns the annotations in a given code element. This strategy, however, is far from the needs of a real framework. The goal of this paper is to propose a novel API, named Esfinge Metadata, to assist in the development of frameworks based on metadata and applications based on custom annotations. Being based on annotations itself, this new API uses them to map metadata to class members. We carried out an experiment to evaluate our API and its impact on aspects such as code structure, complexity, and coupling, while also performing a comparison with the direct use of the Java Reflection API. The participants implemented a metadata-based framework based on realistic requirements in a sequence of 10 tasks that took an average of nine hours. As a result, participants that used our API maintained a more stable code evolution, regarding complexity and coupling as opposed to participants using the Java Reflection API, where the code metrics evolution and structure vary greatly.
Angular Momentum Flows without anything carrying it
Creators: name: Aharonov, Yakir
name: Collins, Daniel
name: Popescu, Sandu
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Transfer of conserved quantities between two remote regions is generally assumed to be a rather trivial process: a flux of particles carrying the conserved quantities propagates from one region to another. We however demonstrate a flow of angular momentum from one region to another across a region of space in which there is a vanishingly small probability of any particles (or fields) being present. This shows that the usual view of how conservation laws work needs to be revisited.
description: V4: 8 Pages, 2 Figures, minor improvements
title: Radiofrequency ablation of thyroid nodules. Indications and technique.
Creators: name: Pérez Naranjo, Paula
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: Interventional non-vascular
subject: Thyroid / Parathyroids
subject: Ultrasound
subject: Ablation procedures
subject: Diagnostic procedure
subject: Education and training
subject: Endocrine disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describe the existing interventional technique for percutaneous locoregional treatment for thyroid gland nodules. Study the selection criteria for the selected...
On-Chip Quantum Interference from a Single Silicon Ring Resonator Source
Creators: name: Preble, Stefan F.
name: Fanto, Michael L.
name: Steidle, Jeffrey A.
name: Tison, Christopher C.
name: Howland, Gregory A.
name: Wang, Zihao
name: Alsing, Paul M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Here we demonstrate quantum interference of photons on a Silicon chip produced from a single ring resonator photon source. The source is seamlessly integrated with a Mach-Zehnder interferometer, which path entangles degenerate bi-photons produced via spontaneous four wave mixing in the Silicon ring resonator. The resulting bi-photon N00N state is controlled by varying the relative phase of the integrated Mach-Zehnder interferometer, resulting in high two-photon interference visibilities of V~96%. Furthermore, we show that the interference can be produced using pump wavelengths tuned to all of the ring resonances accessible with our tunable lasers (C+L band). This work is a key demonstration towards the simplified integration of multiple photon sources and quantum circuits together on a monolithic chip, in turn, enabling quantum information chips with much greater complexity and functionality.
title: Central Nervous System manifestations of Type 1 Neurofibromatosis: spectrum of MRI findings
Creators: name: Di Pietro, Stefano
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Neuroradiology spine
subject: MR
subject: MR-Spectroscopy
subject: Diagnostic procedure
subject: Imaging sequences
subject: Genetic defects

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To illustrate the main Central Nervous System (CNS) manifestations of Type 1 Neurofibromatosis (NF1) – focusing on its magnetic resonance imaging (MRI)...
(401780) John Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Multidisciplinary approach of maxillofacial tumors: 3D imaging planning
Creators: name: Cayón Somacarrera, Silvia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Computer applications
subject: Head and neck
subject: Management
subject: Cone beam CT
subject: CT
subject: MR
subject: Computer Applications-3D
subject: Intensity Modulated Radiotherapy (IMRT)
subject: VMAT and Tomotherapy
subject: Multidisciplinary cancer care

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To learn about the role of the radiologist in 3D imaging analysis and planning in craniomaxillofacial surgery. To learn about the multidisciplinary management of head and neck cancer, including surgical, radiotherapy and pathological...
title: Classic signs and artifacts in hepatobiliary ultrasonography
Creators: name: Mota, Cristina
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Biliary Tract / Gallbladder
subject: Liver
subject: Ultrasound
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: We aim to provide a “pictorial review” of the classic signs and artifacts in hepatobiliary...
Observational constraints on cosmological models with Chaplygin gas and quadratic equation of state
Creators: name: Sharov, G. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Observational manifestations of accelerated expansion of the universe, in particular, recent data for Type Ia supernovae, baryon acoustic oscillations, for the Hubble parameter $H(z)$ and cosmic microwave background constraints are described with different cosmological models. We compare the $Λ$CDM, the models with generalized and modified Chaplygin gas and the model with quadratic equation of state. For these models we estimate optimal model parameters and their permissible errors with different approaches to calculation of sound horizon scale $r_s(z_d)$. Among the considered models the best value of $χ^2$ is achieved for the model with quadratic equation of state, but it has 2 additional parameters in comparison with the $Λ$CDM and therefore is not favored by the Akaike information criterion.
description: 20 pages, 4 figures, revised version for JCAP
(401775) Isabella [Lyon]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway
Creators: name: Siamakpour-Reihani, Sharareh
name: Arbiser, Jack L.
name: Livasy, Chad
name: Hilliard, Eleanor
name: Patterson, Cam
name: Fried, Levi
name: Banet, Natalie
name: Ketelsen, David
name: Courtwright, Andrew
name: Nepal, Desh Bandhu
name: Klauber-DeMore, Nancy
name: Perou, Charles M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Secreted frizzle-related protein 2 (SFRP2), a modulator of Wnt-signaling, has recently been found to be overexpressed in the vasculature of 85% of human breast tumors, however its role in angiogenesis is unknown. We found that SFRP2 induced angiogenesis in the mouse Matrigel plug assay and the chick chorioallantoic membrane assay. SFRP2 inhibited hypoxia induced endothelial cell apoptosis, increased endothelial cell migration, and induced endothelial tube formation. The canonical Wnt-pathway was not affected by SFRP2 in endothelial cells, however, a component of the non-canonical Wnt/Ca++ pathway was affected by SFRP2, as demonstrated by an increase in NFATc3 in the nuclear fraction of SFRP2-treated endothelial cells. Tacrolimus, a calcineurin inhibitor which inhibits dephosphorylation of NFAT, inhibited SFRP2-induced endothelial tube formation. Tacrolimus 3 mg/kg/daily inhibited the growth of SVR angiosarcoma xenografts in mice by 46% (p=0.04). In conclusion, SFRP2 is a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway, and may be a favorable target for the inhibition of angiogenesis in solid tumors.
Re-evaluating Retrosynthesis Algorithms with Syntheseus
Creators: name: Maziarz, Krzysztof
name: Tripp, Austin
name: Liu, Guoqing
name: Stanley, Megan
name: Xie, Shufang
name: Gaiński, Piotr
name: Seidl, Philipp
name: Segler, Marwin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Automated Synthesis Planning has recently re-emerged as a research area at the intersection of chemistry and machine learning. Despite the appearance of steady progress, we argue that imperfect benchmarks and inconsistent comparisons mask systematic shortcomings of existing techniques, and unnecessarily hamper progress. To remedy this, we present a synthesis planning library with an extensive benchmarking framework, called syntheseus, which promotes best practice by default, enabling consistent meaningful evaluation of single-step models and multi-step planning algorithms. We demonstrate the capabilities of syntheseus by re-evaluating several previous retrosynthesis algorithms, and find that the ranking of state-of-the-art models changes in controlled evaluation experiments. We end with guidance for future works in this area, and call the community to engage in the discussion on how to improve benchmarks for synthesis planning.
description: Accepted for publication in Faraday Discussions
Phegea 51-1. Book Review. Klausnitzer B., Klausnitzer H. & Wachmann E. 2022. Marienkäfer. Coccinellidae. 5., stark überarbeitete und erweiterte Auflage.
Creators: name: De Prins, Willy
Publisher: name: figshare
Year: 2023
Subjects: Invertebrate biology

description: Dit is inmiddels het 451ste deel uit de bekende Brehm-Bücherei en deze vijfde uitgave lijkt helemaal niet meer op de vorige edities die veel minder soorten en foto's bevatten en ook heel wat minder informatie over de biologie, het voorkomen, de verspreiding, enz. van de verschillende soorten lieveheersbeestjes. Deze bekende insectengroep, algemeen bekend bij het brede publiek, en geliefd bij kinderen die door het aantal stippen op de dekschilden de leeftijd van de diertjes proberen te bepalen, verdiende inderdaad wat meer aandacht in deze prestigieuze reeks boeken. Nieuw in deze uitgave is o.a. dat alle 99 in Midden-Europa voorkomende Coccinellidae-soorten in het boek zijn opgenomen, met daarbij ook 7 geïmporteerde soorten en nog eens 11 soorten die net buiten het besproken areaal voorkomen. De soorten uit volgende landen worden integraal behandeld: België, Duitsland, Frankrijk (enkel het noordoostelijke deel), Liechtenstein, Luxemburg, Nederland, Oostenrijk, Polen, Slowakije, Tsjechië en Zwitserland. In het eerste hoofdstuk worden de morfologie en systematiek van lieveheersbeestjes behandeld. Dit gebeurt met vele schematische tekeningen en tabellen maar ook met mooie kleurenfoto's. In een afzonderlijke paragraaf wordt de uitzonderlijke individuele variabiliteit van enkele soorten besproken, met daarbij een overzicht van niet minder dan 107 vormen bij Adalia decempunctata, voorgesteld door evenveel duidelijke pentekeningen.
title: Cervical metastatic lymphadenopathy as first presentation of remotely neoplastic disease
Creators: name: Silaghi, Horia-Mircea
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: Lymph nodes
subject: Oncology
subject: CT
subject: MR
subject: Ultrasound
subject: Education
subject: Radiation therapy / Oncology
subject: Cancer
subject: Metastases
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Cervical lymphadenopathy is a common clinical finding and the most usual causes are related to head and neck pathologies. The purpose of this educational exhibit is to discuss the role of imaging techniques in the assessment of cervical lymph nodes,...
Dimensionality crossover to 2D vestigial nematicity from 3D zigzag antiferromagnetism in an XY-type honeycomb van der Waals magnet
Creators: name: Sun, Zeliang
name: Ye, Gaihua
name: Huang, Mengqi
name: Zhou, Chengkang
name: Huang, Nan
name: Li, Qiuyang
name: Ye, Zhipeng
name: Nnokwe, Cynthia
name: Deng, Hui
name: Mandrus, David
name: Meng, Zi Yang
name: Sun, Kai
name: Du, Chunhui
name: He, Rui
name: Zhao, Liuyan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Fluctuations and disorder effects are substantially enhanced in reduced dimensionalities. While they are mostly considered as the foe for long-range orders, fluctuations and disorders can also stimulate the emergence of novel phases of matter, for example, vestigial orders. Taking 2D magnetism as a platform, existing efforts have been focused on maintaining 2D long-range magnetic orders by suppressing fluctuations, whereas the other side, exploiting fluctuations for realizing new 2D magnetic phases, remains as an uncharted territory. Here, using a combination of NV spin relaxometry, optical spectroscopy, and Monte Carlo simulations, we report, in an XY-type honeycomb magnet NiPS3, the phase transition from the zigzag AFM order in 3D bulk to a new Z3 vestigial Potts-nematicity in 2D few layers. Spin fluctuations are shown to significantly enhance over the GHz-THz range as the layer number of NiPS3 reduces, using the NV spin relaxometry and the optical Raman quasi-elastic scattering. As a result, the Raman signatures of the zigzag AFM for bulk NiPS3, a zone-folded phonon at ~30cm-1 from the broken translational symmetry (PBTS) and a degeneracy lift of two phonons at ~180cm-1 for the broken 3-fold rotational symmetry (PBRS), evolve into the disappearance of PBTS and the survival of PBRS in few-layer NiPS3, with a critical thickness of ~10nm. The optical linear dichroism microscopy images all three nematic domain states in a single few-layer NiPS3 flake. The large-scale Monte Carlo simulations for bilayer NiPS3 model confirms the absence of long-range zigzag AFM order but the formation of the Z3 vestigial Potts-nematic phase, corroborating with the experimental finding. Our results demonstrate the positivity of strong fluctuations in creating new phases of matter after destroying more conventional ones, and offer an unprecedented pathway for developing novel 2D phases.
(401776) Margaret Cobb
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.