cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Tet-on system for controllable gene expression in the rock-inhabiting black fungus Knufia petricola
Creators: name: Erdmann, Eileen A.
name: Brandhorst, Antonia K. M.
name: Gorbushina, Anna A.
name: Schumacher, Julia
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Microcolonial fungi
subject: Inducible promoter
subject: Bimolecular fluorescence complementation
subject: 2A peptide
subject: CRISPR/Cas9-mediated genome editing
subject: Pigment synthesis
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Knufia petricola is a black fungus that colonizes sun-exposed surfaces as extreme and oligotrophic environments. As ecologically important heterotrophs and biofilm-formers on human-made surfaces, black fungi form one of the most resistant groups of biodeteriorating organisms. Due to its moderate growth rate in axenic culture and available protocols for its transformation and CRISPR/Cas9-mediated genome editing, K. petricola is used for studying the morpho-physiological adaptations shared by extremophilic and extremotolerant black fungi. In this study, the bacteria-derived tetracycline (TET)-dependent promoter (Tet-on) system was implemented to enable controllable gene expression in K. petricola. The functionality i.e., the dose-dependent inducibility of TET-regulated constructs was investigated by using GFP fluorescence, pigment synthesis (melanin and carotenoids) and restored uracil prototrophy as reporters. The newly generated cloning vectors containing the Tet-on construct, and the validated sites in the K. petricola genome for color-selectable or neutral insertion of expression constructs complete the reverse genetics toolbox. One or multiple genes can be expressed on demand from different genomic loci or from a single construct by using 2A self-cleaving peptides, e.g., for localizing proteins and protein complexes in the K. petricola cell or for using K. petricola as host for the expression of heterologous genes.
Declaration of Intention of Harry Adolf William Strassburg
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1918

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Harry Adolf William Strassburg Applicant age:50Occupation: Liquor BusinessCountry of Origin:GermanyDate of Birth: 3 May 1867Sailed to the US aboard the vessel: LahnCity of residence at time of declaration: Atlantic City, NJDeclaration submitted and sworn on date:21 January 1918
The impact of highly active antiretroviral therapy on prevalence and incidence of cervical human papillomavirus infections in HIV-positive adolescents
Creators: name: Smith, Jennifer
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background The implementation of highly active antiretroviral therapy (HAART) among HIV-positive patients results in immune reconstitution, slower progression of HIV disease, and a decrease in the occurrence of opportunistic infections. However, the impact of HAART on cervical human papillomavirus (HPV) infection, clearance, and persistence in high-risk adolescents remains controversial. Methods HIV-positive and high-risk HIV-negative female adolescents were enrolled in the Reaching for Excellence in Adolescent Care and Health (REACH) longitudinal cohort study. At each semi-annual clinical visit, cervical lavage samples were tested for 30 HPV types. Type-specific and carcinogenic risk-specific HPV prevalence and incidence were compared in 373 eligible participants: 146 HIV-negative female adolescents with a median follow-up of 721.5 [IQR: 483-1301] days and 227 HIV-positive female adolescents. Of the 227 HIV-positive participants, a fixed set (n = 100) were examined both before and after HAART initiation; 70 were examined only before HAART initiation; and 57 were examined only after HAART initiation, with overall median follow-up of 271 [IQR: 86.5-473] and 427.25 [IQR: 200-871] days respectively for before and after HAART initiation. Results Of the 373 eligible participants, 262 (70%) were infected with at least one type of HPV at baseline, and 78 of the remaining 111 (70%) became infected with at least one type of HPV by the end of the study. Overall, the incidence and prevalence of HPV types 58, 53/66, 68/70, and 31/33/35 were much higher than the established carcinogenic and HPV vaccine types 16 and 18, especially in HIV-positive females both before and after HAART initiation. Baseline prevalence for individual high-risk HPV types ranged, depending on type, from 0.7-10%, 1-17%, and 1-18% in the HIV-negative group, the HIV-positive before HAART initiation group, and the HIV-positive after HAART initiation group, respectively. Likewise, the incidence ranged, depending on HPV type, from 0.64-9.83 cases/100 PY, 3.00-12.80 cases/100 PY, and 1.49-17.05 cases/100 PY in the three groups, respectively. The patterns of each HPV type infection, clearance, and persistence did not differ considerably before or after the introduction of HAART and were clearly independent of CD4+ change within the short post-HAART follow-up period. Conclusions HAART did not immediately affect the incidence of type-specific HPV infections within a short-period follow-up; however, future studies are warranted in larger populations to evaluate HAART's impact over longer periods.
Effects of Venture Capital Network Centrality on Earnings Management During an IPO Lockup: Evidence from the US Market
Creators: name: Yosavee Niranvichaiya
Publisher: name: Chulalongkorn Business school, Chulalongkorn University.
Year: 2022
Subjects: Venture Capital
Earnings Management
Network Centrality

description: Creative Business and Sustainability Journal, 44, 2, 41-60
One-loop matching for transversity generalized parton distribution
Creators: name: Xiong, Xiaonu
name: Zhang, Jian-Hui
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent developments showed that light cone parton distributions can be studied by investigating the large momentum limit of the so-called quasiparton distributions, which are defined in terms of spacelike correlators, and therefore can be readily computed on the lattice. These two distributions can be connected to each other by a perturbative factorization formula or matching condition that allows one to convert the latter into the former. Here we present the one-loop matching condition for the transversity generalized quark distribution in the nonsinglet case
Declaration of Intention of Hans Fred Letsch
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1916

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Hans Fred Letsch Applicant age: 23Occupation: CookCountry of Origin: GermanyDate of Birth: 18 June 1893Sailed to the US aboard the vessel: Cincinnati City of residence at time of declaration: Atlantic City, NJDeclaration submitted and sworn on date: 19 September 1916
Session 3 Figures du plan : La ceinture verte
Creators: name: Tiry-Ono, Corinne
Publisher: name: Collectif Inventer le Grand Paris
Year: 2023

description: Je voudrais tout d'abord remercier les organisateurs de cette journée passionnante de mise en miroir, ou en résonance, du Grand Paris et du Grand Tokyo, à travers le sujet de la métropole et des parcs. Cette troisième et dernière session va s'intéresser plus particulièrement à la question métropolitaine à travers la figure de la ceinture verte, notamment de la place et du rôle de cette figure dans la définition et l'aménagement du Grand Tokyo, comme du Grand Paris, à l'échelle d'un siècle environ, entre les années 1920 et les années 2020. Dans l'histoire de l'urbanisme, le principe de ceinture...
Apolipoprotein epsilon-4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
Creators: name: North, Kari
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract: Background: We sought to examine whether ε4 carrier status modifies the relation between body mass index (BMI) and HDL. The National Heart, Lung, and Blood Institute Family Heart Study included 657 families with high family risk scores for coronary heart disease and 588 randomly selected families of probands in the Framingham, Atherosclerosis Risk in Communities, and Utah Family Health Tree studies. We selected 1402 subjects who had ε4 carrier status available. We used generalized estimating equations to examine the interaction between BMI and ε4 allele carrier status on HDL after adjusting for age, gender, smoking, alcohol intake, mono- and poly-unsaturated fat intake, exercise, comorbidities, LDL, and family cluster. Results: The mean (standard deviation) age of included subjects was 56.4(11.0) years and 47% were male. Adjusted means of HDL for normal, overweight, and obese BMI categories were 51.2(± 0.97), 45.0(± 0.75), and 41.6(± 0.93), respectively, among 397 ε4 carriers (p for trend < 0.0001) and 53.6(± 0.62), 51.3(± 0.49), and 45.0(± 0.62), respectively, among 1005 non-carriers of the ε4 allele (p-value for trend < 0.0001). There was no evidence for an interaction between BMI and ε4 status on HDL(p-value 0.39). Conclusion: Our findings do not support an interaction between ε4 allele status and BMI on HDL.
Effects of a Governing Body on Internal Audit Quality: Empirical Evidence from Thailand
Creators: name: Usarat Thirathon
Publisher: name: Chulalongkorn Business school, Chulalongkorn University.
Year: 2022
Subjects: Governing Body
Internal Audit Support
Internal Audit Quality
Corporate Governance

description: Creative Business and Sustainability Journal, 44, 2, 61-79
Declaration of Intention of Anton Mark
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1908

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Anton Mark Applicant age: 38Occupation: FarmerCountry of Origin: HungaryDate of Birth: 29 April 1869Sailed to the US aboard the vessel: FatherlandCity of residence at time of declaration: Egg Harbor City, NJDeclaration submitted and sworn on date: 13 March, 1908
Do You Think Your Students are into Online Learning? Brain Responses Using Electroencephalography
Creators: name: Arisaphat Suttidee
Publisher: name: Chulalongkorn Business school, Chulalongkorn University.
Year: 2022
Subjects: Cognitive
EEG
Brain
Affective Cognitive
Online Instruction

description: Creative Business and Sustainability Journal, 44, 2, 80-94
Building CSR Communication in the Banking Business in Thailand: The Mediating Effects of Social Media Influencers and Consumer Skepticism
Creators: name: Fauzan, Nizar
Publisher: name: Chulalongkorn Business school, Chulalongkorn University.
Year: 2022
Subjects: Social Media Influencers
Consumer Skepticism
CSR communication
Customer Value Co-creation

description: Creative Business and Sustainability Journal, 44, 2, 95-113
Demand control law for total energy angle tested at manual steep approaches
Creators: name: Schreiter, Karolin
name: Müller, Simon
name: Luckner, Robert
name: Manzey, Dietrich
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: nxControl system
subject: manual flight
subject: flight control system
subject: augmented flight control
subject: human machine interface
subject: total energy angle
subject: flight simulator study
subject: workload
subject: flight precision
subject: steep RNP approach

description: With rising demands on flight precision and more complex flight trajectories, pilots' workload during manual flight is increasing. This is especially the case for flight path and speed control with thrust and spoilers during approach and landing. The objective of the nxControl system is to enable pilots to manually control the longitudinal load factor nx instead of engine parameters and spoiler deflections. This load factor is equivalent to total energy angle. It is directly influenced by engine thrust and aerodynamic drag. The nxController shall complement the existing fly-by-wire control laws of today's commercial airliners. It aims at higher precision with lower workload during manual flight. The pilots set and monitor the controller input and impact by an adapted human-machine interface consisting of a thrust-lever-like inceptor and additional display elements to enhance energy awareness. This paper describes the nxControl system with focus on the demand control law and an evaluation study with 24 airline pilots in a research flight simulator. The task was a demanding, steep, and curved approach in the mountainous area of Salzburg airport with required navigation performance RNP 0.1. The results show that despite minimal training the pilots achieved higher precision in speed and energy control with lower physical workload with the nxControl system.
Learning the kernel matrix via predictive low-rank approximations
Creators: name: Stražar, Martin
name: Curk, Tomaž
Publisher: name: arXiv
Year: 2016
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Efficient and accurate low-rank approximations of multiple data sources are essential in the era of big data. The scaling of kernel-based learning algorithms to large datasets is limited by the O(n^2) computation and storage complexity of the full kernel matrix, which is required by most of the recent kernel learning algorithms. We present the Mklaren algorithm to approximate multiple kernel matrices learn a regression model, which is entirely based on geometrical concepts. The algorithm does not require access to full kernel matrices yet it accounts for the correlations between all kernels. It uses Incomplete Cholesky decomposition, where pivot selection is based on least-angle regression in the combined, low-dimensional feature space. The algorithm has linear complexity in the number of data points and kernels. When explicit feature space induced by the kernel can be constructed, a mapping from the dual to the primal Ridge regression weights is used for model interpretation. The Mklaren algorithm was tested on eight standard regression datasets. It outperforms contemporary kernel matrix approximation approaches when learning with multiple kernels. It identifies relevant kernels, achieving highest explained variance than other multiple kernel learning methods for the same number of iterations. Test accuracy, equivalent to the one using full kernel matrices, was achieved with at significantly lower approximation ranks. A difference in run times of two orders of magnitude was observed when either the number of samples or kernels exceeds 3000.
description: 10 pages, 4 figures
Matchings with lower quotas: algorithms and complexity
Creators: name: Arulselvan, Ashwin
name: Cseh, Ágnes
name: Groß, Martin
name: Manlove, David F.
name: Matuschke, Jannik
Publisher: name: Technische Universität Berlin
Year: 2016
Subjects: subject: 510 Mathematik
subject: 004 Datenverarbeitung; Informatik
subject: maximum matching
subject: many-to-one matching
subject: project allocation
subject: inapproximability
subject: bounded treewidth

description: We study a natural generalization of the maximum weight many-to-one matching problem. We are given an undirected bipartite graph G=(A∪˙P,E) with weights on the edges in E, and with lower and upper quotas on the vertices in P. We seek a maximum weight many-to-one matching satisfying two sets of constraints: vertices in A are incident to at most one matching edge, while vertices in P are either unmatched or they are incident to a number of matching edges between their lower and upper quota. This problem, which we call maximum weight many-to-one matching with lower and upper quotas (WMLQ), has applications to the assignment of students to projects within university courses, where there are constraints on the minimum and maximum numbers of students that must be assigned to each project. In this paper, we provide a comprehensive analysis of the complexity of WMLQ from the viewpoints of classical polynomial time algorithms, fixed-parameter tractability, as well as approximability. We draw the line between NP-hard and polynomially tractable instances in terms of degree and quota constraints and provide efficient algorithms to solve the tractable ones. We further show that the problem can be solved in polynomial time for instances with bounded treewidth; however, the corresponding runtime is exponential in the treewidth with the maximum upper quota umax as basis, and we prove that this dependence is necessary unless FPT=W[1]. The approximability of WMLQ is also discussed: we present an approximation algorithm for the general case with performance guarantee umax+1, which is asymptotically best possible unless P=NP. Finally, we elaborate on how most of our positive results carry over to matchings in arbitrary graphs with lower quotas.
Relazione quinquennale sull'attuazione dei principi della Scienza Aperta nell'Università di Trento (2015-2020)
Creators: name: Ufficio Pubblicazioni Scientifiche-Open Access, Anagrafe Ricerca
name: Divisione Biblioteca Digitale
name: Divisione Supporto Ricerca Scientifica E Trasferimento Tecnologico
name: Ufficio Gestione Patrimonio Informativo E Processi
name: Delegato Del Rettore Per L'Open Access E Le Politiche Contro Il Plagio
Publisher: name: Zenodo
Year: 2023
Subjects: Università di Trento
Report
Open Science

description: La relazione riporta lo stato d'attuazione dei principi e delle politiche per la Scienza Aperta presso l'Università di Trento negli anni 2015-2020.
Declaration of Intention of August Janitzky
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: August Janitzky Applicant age:35Occupation: ButcherCountry of Origin: GermanyDate of Birth: 6th May 1885Sailed to the US aboard the vessel: Sicily City of residence at time of declaration: Egg Harbor City NJDeclaration submitted and sworn on date: 28th September 1917
Declaration of Intention of Jacob Michol Roesch
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Jacob Michol Roesch Applicant age:41Occupation: BakerCountry of Origin:GermanyDate of Birth: 24th July 1875Sailed to the US aboard the vessel: Unknown City of residence at time of declaration: Atlantic City NJDeclaration submitted and sworn on date: 26th March 1917
Declaration of Intention of Eugene Zimmermann
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Eugene Zimmermann Applicant age: 35Occupation: laborerCountry of Origin: GermanyDate of Birth: 12 June 1881Sailed to the US aboard the vessel: Hamburg Germany City of residence at time of declaration: Mays Landing, NJDeclaration submitted and sworn on date: 9 February 1917
Evaluation of an energy- and exergy-based generic modeling approach of combined heat and power plants
Creators: name: Mollenhauer, Eike
name: Christidis, Andreas
name: Tsatsaronis, George
Publisher: name: Technische Universität Berlin
Year: 2016
Subjects: subject: 333.7 Natürliche Ressourcen, Energie und Umwelt
subject: CHP
subject: combined heat and power
subject: MILP
subject: mixed integer linear programs
subject: district heating
subject: cogeneration
subject: extraction condensing turbine
subject: thermodynamic simulation
subject: exergy
subject: unit commitment

description: Reduced models of combined heat and power plants are required for different applications. Among other usages, they are implemented as mixed integer linear programs (MILP) in energy market models or price-based unit commitment problems to study the economic feasibility and optimal operation strategies of different units. Generic models are particularly useful when limited information is available for each considered plant. This paper presents a MILP modeling approach for combined heat and power (CHP) plants. The approach is based on energy and exergy balances and a few typical plant characteristics for different operating conditions. The reduction of electrical power output due to heat extraction is estimated by the transferred exergy to the district heating network. Furthermore, the accuracy, strengths and limitations of this approach are investigated for various CHP plant types with extraction condensing turbines designed for district heating systems. Therefore, detailed thermodynamic cycle simulations of CHP plants including part load operations are used to obtain the real plant operating conditions to compare them to the results of the described generic approach. The validation of the reduced, generic model shows that the accuracy mainly depends on the effectiveness of the heat extraction from the CHP plant. In addition, it can be seen that the main advantage of the presented exergy-based method is the inherent consideration of the feed flow temperature for the calculation of the power reduction due to heat extraction.
Are maximum magnitudes of induced earthquakes controlled by pressure diffusion?
Creators: name: Langenbruch, Cornelius
name: Moein, Mohammad J. A.
name: Shapiro, Serge A.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: induced earthquakes
subject: seismic hazard
subject: seismology
subject: geo-energy
subject: magnitude
subject: earthquake physics
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: There is an ongoing discussion about how to forecast the maximum magnitudes of induced earthquakes based on operational parameters, subsurface conditions and physical process understanding. Although the occurrence of damage caused by induced earthquakes is rare, some cases have caused significant economic loss, injuries and even loss of life. We analysed a global compilation of earthquakes induced by hydraulic fracturing, geothermal reservoir stimulation, water disposal, gas storage and reservoir impoundment. Our analysis showed that maximum magnitudes scale with the characteristic length of pressure diffusion in the brittle Earth’s crust. We observed an increase in the nucleation potential of larger-magnitude earthquakes with time and explained it by diffusion-controlled growth of the pressure-perturbed part of faults. Numerical and analytical fault size modelling supported our findings. Finally, we derived magnitude scaling laws to manage induced seismic hazard of upcoming energy projects prior to operation. This article is part of the theme issue ‘Induced seismicity in coupled subsurface systems’.
An asymptotic formula for the number of irreducible transformation shift registers
Creators: name: Cohen, Stephen D.
name: Hasan, Sartaj Ul
name: Panario, Daniel
name: Wang, Qiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Information Theory (cs.IT)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 5B33, 12E20, 11T71, 12E05

description: We consider the problem of enumerating the number of irreducible transformation shift registers. We give an asymptotic formula for the number of irreducible transformation shift registers in some special cases. Moreover, we derive a short proof for the exact number of irreducible transformation shift registers of order two using a recent generalization of a theorem of Carlitz.
description: 14 pages
Incorporating higher-order representative features improves prediction in network-based cancer prognosis analysis
Creators: name: Kosorok, Michael
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background In cancer prognosis studies with gene expression measurements, an important goal is to construct gene signatures with predictive power. In this study, we describe the coordination among genes using the weighted coexpression network, where nodes represent genes and nodes are connected if the corresponding genes have similar expression patterns across samples. There are subsets of nodes, called modules, that are tightly connected to each other. In several published studies, it has been suggested that the first principal components of individual modules, also referred to as "eigengenes", may sufficiently represent the corresponding modules. Results In this article, we refer to principal components and their functions as representative features". We investigate higher-order representative features, which include the principal components other than the first ones and second order terms (quadratics and interactions). Two gradient thresholding methods are adopted for regularized estimation and feature selection. Analysis of six prognosis studies on lymphoma and breast cancer shows that incorporating higher-order representative features improves prediction performance over using eigengenes only. Simulation study further shows that prediction performance can be less satisfactory if the representative feature set is not properly chosen. Conclusions This study introduces multiple ways of defining the representative features and effective thresholding regularized estimation approaches. It provides convincing evidence that the higher-order representative features may have important implications for the prediction of cancer prognosis.
Declaration of Intention of Max Leblang
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Max Leblang Applicant age: 29Occupation: Storage ManCountry of Origin: Hungary Date of Birth: 30th October 1887Sailed to the US aboard the vessel: Prince Oscar City of residence at time of declaration: Atlantic City NJ Declaration submitted and sworn on date: 2nd June 1917
Consolidated_Air_Quality_Analysis_2021_2022_Manual.ipynb
Creators: name: Altamar, Astrid
Publisher: name: figshare
Year: 2023
Subjects: Machine learning not elsewhere classified
Data engineering and data science
Air pollution processes and air quality measurement

description: Using the Python ® language in the file called Análisis_Calidad_Aire_Consolidado_2021-2022_Manual.ipynb, the description of the data from each of the aforementioned data sources was made, as well as the completeness of the missing data by means of imputation methods with the technique of Machine Learning called KNNImputer available in the library sklearn.impute to Python,
L’ « espace libres » et son développement dans la ceinture verte au Japon
Creators: name: Noriko Akita 秋田典子
Publisher: name: Collectif Inventer le Grand Paris
Year: 2023

description: Le concept français d'"espace libre" a été introduit comme politique d'espace vert dans les premières années de la modernisation du Japon. Introduit pour la première fois au Japon par Hiroshi Ikeda en 1919, le concept d'"espace libre" a d'abord été accepté mais s'est progressivement transformé sous l'influence des plans de reconstruction du grand tremblement de terre du Kanto de 1923 et de la Conférence internationale d'urbanisme tenue à Amsterdam en 1924. Cette présentation se concentrera sur Hiroshi Ikeda, qui a introduit ce concept, et tentera de répondre à la question difficile de savoir comment le concept d'"espace libre" a été reçu au Japon et comment il a conduit au concept de ceinture verte.
Gene processing control loops suggested by sequencing, splicing, and RNA folding
Creators: name: Jeffries, Clark D
name: Perkins, Diana
name: Guan, Xiaojun
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Small RNAs are known to regulate diverse gene expression processes including translation, transcription, and splicing. Among small RNAs, the microRNAs (miRNAs) of 17 to 27 nucleotides (nts) undergo biogeneses including primary transcription, RNA excision and folding, nuclear export, cytoplasmic processing, and then bioactivity as regulatory agents. We propose that analogous hairpins from RNA molecules that function as part of the spliceosome might also be the source of small, regulatory RNAs (somewhat smaller than miRNAs). Results Deep sequencing technology has enabled discovery of a novel 16-nt RNA sequence in total RNA from human brain that we propose is derived from RNU1, an RNA component of spliceosome assembly. Bioinformatic alignments compel inquiring whether the novel 16-nt sequence or its precursor have a regulatory function as well as determining aspects of how processing intersects with the miRNA biogenesis pathway. Specifically, our preliminary in silico investigations reveal the sequence could regulate splicing factor Arg/Ser rich 1 (SFRS1), a gene coding an essential protein component of the spliceosome. All 16-base source sequences in the UCSC Human Genome Browser are within the 14 instances of RNU1 genes listed in wgEncodeGencodeAutoV3. Furthermore, 10 of the 14 instances of the sequence are also within a common 28-nt hairpin-forming subsequence of RNU1. Conclusions An abundant 16-nt RNA sequence is sourced from a spliceosomal RNA, lies in a stem of a predicted RNA hairpin, and includes reverse complements of subsequences of the 3'UTR of a gene coding for a spliceosome protein. Thus RNU1 could function both as a component of spliceosome assembly and as inhibitor of production of the essential, spliceosome protein coded by SFRS1. Beyond this example, a general procedure is needed for systematic discovery of multiple alignments of sequencing, splicing, and RNA folding data.
Declaration of Intention of Hermann Heinrich Wilhelm George Holtfort
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Herman Heinrich Wilhelm George Holtfort Applicant age:25Occupation: PianistCountry of Origin:GermanyDate of Birth: 29 January 1892Sailed to the US aboard the vessel: President LincolnCity of residence at time of declaration: Atlantic City, NJDeclaration submitted and sworn on date:26 February 1917
Lack of Free Choice Reveals the Cost of Having to Search for More Than One Object
Creators: name: Ort, Eduard
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Visual search, visual attention, eye movements, attentional template, cognitive control

description: Data and material of: Ort, Fahrenfort, and Olivers (in press). Lack of Free Choice Reveals the Cost of Having to Search for More Than One Object. Psychological Science.
Declaration of Intention of Karl Kunz
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Karl Kunz Applicant age: 53Occupation: LaborerCountry of Origin: HungaryDate of Birth: 25th December 1863Sailed to the US aboard the vessel: Kaiserina Victoria August City of residence at time of declaration: Atlantic City NJDeclaration submitted and sworn on date: 6th June 1917
Addressing ecoanxiety through the lens of childrens literature in the elementary art classroom
Creators: name: Andre, Dara
Publisher: name: Georgia State University
Year: 2023

description:
The purpose of this thesis is to investigate the how as an art educator I can incorporate environmentalism into my art lessons without furthering ecoanxiety in my elementary classroom. Through looking into the many years of research behind the field of eco-art education I found that there were many teachers already finding ways to make their classrooms environmentally conscious. I chose to further explore this topic through the medium of illustrated childrens literature in an attempt to uncover new ways to address environmentalism in the classroom without causing further harm to student mental health. Through the process of writing and illustrating a story about young environmentalists, I made personal discoveries about myself as an artists and teacher, and developed my identity as an eco-art educator.
Engraftment of mouse breast cancer cells and treatment with CD47 targeted antibodies
Creators: name: Horrigan, Stephen
name: Iorns, Elizabeth
name: Williams, Stephen
name: Perfito, Nicole
name: Errington, Timothy
Publisher: name: Open Science Framework
Year: 2022

description: Replication attempt of Figures 6A-C and Table S4 from Willingham et al., 2012
On the almost-palindromic width of free groups
Creators: name: Staiger, Manuel
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Free groups
subject: Words
subject: Palindromes
subject: Width
subject: Palindromic width
subject: Almost-palindromic width
subject: 500 Naturwissenschaften und Mathematik::510 Mathematik::510 Mathematik

description: We answer a question of Bardakov (Kourovka Notebook, Problem 19.8) which asks for the existence of a pair of natural numbers (c, c, m ) with the property that every element in the free group on the two-element set { a, b } can be represented as a concatenation of c , or fewer, m-almost-palindromes in letters a +/- 1, +/- 1 , b +/- 1 . Here, an m-almost-palindrome is a word which can be obtained from a palindrome by changing at most m letters. We show that no such pair (c, c, m ) exists. In fact, we show that the analogous result holds for all non-abelian free groups.
Declaration of Intention of Paul Nelke
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1916

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Paul Nelke Applicant age:31Occupation: painterCountry of Origin:GermanyDate of Birth: 23 October 1884Sailed to the US aboard the vessel:Sicilia City of residence at time of declaration:Mays Landing, NJ Declaration submitted and sworn on date:6 October 1916
3D pyCloudy modelling of bipolar planetary nebulae: evidence for fast fading of the lobes
Creators: name: Gesicki, K.
name: Zijlstra, A. A.
name: Morisset, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We apply an axially symmetric pseudo-3D photoionization model, pyCloudy, to derive the structures of 6 bipolar nebulae and 2 suggested post-bipolars in a quest to constrain the bipolar planetary nebulae evolution. HST images and VLT/UVES spectroscopy are used for the modelling. The targets are located in the direction of the Galactic bulge. A 3D model structure is used as input to the photoionization code, so as to fit the HST images. Line profiles of different ions constrain the velocity field. The model and associated velocity fields allow us to derive masses, velocities, and ages. The 3D models find much lower ionized masses than required in 1D models: ionized masses are reduced by factors of 2-7. The selected bi-lobed planetary nebulae show a narrow range of ages: the averaged radii and velocities result in values between 1300 and 2000 yr. The lobes are fitted well with velocities linearly increasing with radius. These Hubble-type flows have been found before, and suggest that the lobes form at a defined point in time. The lobes appear to be slightly younger than the main (host) nebulae, by ~500 yr, they seem to form at an early phase of PN evolution, and fade after 1-2 kyr. We find that 30-35% of bulge PNe pass through a bipolar phase.
description: 14 pages, 13 figures, 2 tables, accepted for Astronomy & Astrophysics
Enhancing manual flight precision and reducing pilot workload using a new manual control augmentation system for energy angle
Creators: name: Schreiter, Karolin
name: Müller, Simon
name: Luckner, Robert
name: Manzey, Dietrich
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: nxControl system
subject: manual flight
subject: flight control system
subject: augmented flight control
subject: human machine interface
subject: total energy angle
subject: flight simulator study
subject: workload
subject: flight precision
subject: steep RNP approach

description: With rising demands on flight precision and more complex flight trajectories, pilots' workload during manual flight is increasing. This is especially the case for thrust and spoiler control during approach and landing. The presented nxControl system enables pilots to manually control the longitudinal load factor nx instead of engine parameters and spoiler deflections. This load factor is equivalent to total energy angle and is directly influenced by engine thrust and aerodynamic drag. The nxController complements existing control augmentation systems such as the fly-by-wire control laws of today's commercial airliners. It aims at higher precision with lower workload during manual flight. The controller input can be set and monitored by an adapted human-machine interface consisting of a thrust-lever-like inceptor and additional display elements to enhance energy awareness. This paper presents the nxControl system with focus on the command control system and an evaluation study with 24 airline pilots in a research flight simulator. The task was a demanding and steep approach with required navigation performance RNP 0.1 in a mountainous area. The results show higher precision and lower workload with the nxControl system despite minimal amount of training.
Stress, resilience, and coping resources in the context of war, terror, and migration
Creators: name: Schwarzer, Ralf
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: coping resources
subject: recovery
subject: traumatic experiences
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Within the transactional framework of stress, resilience may be conceptualized as a dynamic process wherein individuals, when confronted with adversity, utilize both internal and external coping resources. This article focuses on two resources, namely self-efficacy and social support, examining their roles in the context of war, terrorism, and forced migration. These resources are perceived as protective factors capable of mitigating the impact of adversity and aiding in the recovery from traumatic experiences. They facilitate individuals in reshaping their perspectives and engaging in cognitive restructuring as integral components of the coping process, ultimately leading to a rebound from adversity or even the development of higher levels of functioning post trauma. When scrutinizing the trajectories of coping resources over time, distinct mechanisms may come to the fore. A causation model posits a positive effect of resources on recovery outcomes, while an erosion model elucidates the wear and tear that ongoing adversity may inflict upon these resources. In exploring the interplay between self-efficacy and social support within the resilience process, diverse mechanisms may emerge. These include the enabling effect, where support enhances self-efficacy, and the cultivation effect, wherein self-efficacy contributes to the development of robust social networks.
Optimizing spinning time-domain gravitational waveforms for Advanced LIGO data analysis
Creators: name: Devine, Caleb
name: Etienne, Zachariah B.
name: McWilliams, Sean T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: 83C35

description: The Spinning Effective One Body-Numerical Relativity (SEOBNR) series of gravitational wave approximants are among the best available for Advanced LIGO data analysis. Unfortunately, SEOBNR codes as they currently exist within LALSuite are generally too slow to be directly useful for standard Markov-Chain Monte Carlo-based parameter estimation (PE). Reduced-Order Models (ROMs) of SEOBNR have been developed for this purpose, but there is no known way to make ROMs of the full eight-dimensional intrinsic parameter space more efficient for PE than the SEOBNR codes directly. So as a proof of principle, we have sped up the original LALSuite SEOBNRv2 approximant code, which models waveforms from aligned-spin systems, by nearly 300x. Our optimized code shortens the timescale for conducting PE with this approximant to months, assuming a purely serial analysis, so that even modest parallelization combined with our optimized code will make running the full PE pipeline with SEOBNR codes directly a realistic possibility. A number of our SEOBNRv2 optimizations have already been applied to SEOBNRv3, a new approximant capable of modeling sources with all eight (precessing) intrinsic degrees of freedom. We anticipate that once all of our optimizations have been applied to SEOBNRv3, a similar speed-up may be achieved.
description: 17 pages, 5 figures. Matches published version
Three approaches to glucose monitoring in non-insulin treated diabetes: a pragmatic randomized clinical trial protocol
Creators: name: Buse, John
name: Donahue, Katrina
name: Blakeney, Tamara
name: Young, Laura A
name: Grimm, Kimberlea
name: Rees, Jennifer
name: Mitchell, C Madeline
name: Vu, Maihan B
name: Weaver, Mark
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background For the nearly 75% of patients living with type 2 diabetes (T2DM) that do not use insulin, decisions regarding self-monitoring of blood glucose (SMBG) can be especially problematic. While in theory SMBG holds great promise for sparking favorable behavior change, it is a resource intensive activity without firmly established patient benefits. This study describes our study protocol to assess the impact of three different SMBG testing approaches on patient-centered outcomes in patients with non-insulin treated T2DM within a community-based, clinic setting. Methods/Design Using stakeholder engagement approach, we developed and implemented a pragmatic trial of patient with non-insulin treated T2DM patients from five primary care practices randomized to one of three SMBG regimens: 1) no testing; 2) once daily testing with standard feedback consisting of glucose values being immediately reported to the patient through the glucose meter; and 3) once daily testing with enhanced patient feedback consisting of glucose values being immediately reported to the patient PLUS automated, tailored feedback messaging delivered to the patient through the glucose meter following each testing. Main outcomes assessed at 52 weeks include quality of life and glycemic control. Discussion This pragmatic trial seeks to better understand the value of SMBG in non-insulin treated patients with T2DM. This paper outlines the protocol used to implement this study in fifteen community-based primary care practices and highlights the impact of stakeholder involvement from the earliest stages of project conception and implementation. Plans for stakeholder involvement for result dissemination are also discussed. Trial registration ClinicalTrials.gov NCT02033499 , January 9, 2014.
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing
Creators: name: Haltenhof, Tom
name: Preußner, Marco
name: Heyd, Florian
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: alternative splicing
subject: body temperature
subject: nonsense-mediated decay
subject: RNA
subject: SR proteins
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to adapt to varying environmental temperatures. In mammals, even slight fluctuations in body temperature are sufficient to drive significant AS changes in a concerted manner. This dynamic regulation allows organisms to finely tune gene expression and protein isoform diversity in response to temperature cues, ensuring proper cellular function and physiological adaptation. Understanding the molecular mechanisms underlying temperature-dependent AS thus provides valuable insights into the intricate interplay between environmental stimuli and gene expression regulation. In this review, we provide an overview of recent advances in understanding temperature-regulated AS across various biological processes and systems. We will discuss the machinery sensing and translating temperature cues into changed AS patterns, the adaptation of the splicing regulatory machinery to extreme temperatures, the role of temperature-dependent AS in shaping the transcriptome, functional implications and the development of potential therapeutics targeting temperature-sensitive AS pathways.
Declaration of Intention of Gerald Frederick Hawkins
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1917

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by:Gerald Frederick Hawkins Applicant age:23Occupation: FarmerCountry of Origin:EnglandDate of Birth: 26 August 1893Sailed to the US aboard the vessel: Oceanic City of residence at time of declaration: Elwood NJDeclaration submitted and sworn on date:19 April 1917
Declaration of Intention of John Jacob Queck
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1915

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: John Jacob Queck Applicant age:36Occupation: FarmerCountry of Origin: GermanyDate of Birth: 23rd October 1878Sailed to the US aboard the vessel: Witteking City of residence at time of declaration: Egg Harbor City NJDeclaration submitted and sworn on date: 18th February 1915
Declaration of Intention of Joseph Dvorak
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1924

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Joseph Dvorak Applicant age:63Occupation: FarmerCountry of Origin:BohemiaDate of Birth:19 March 1860 Sailed to the US aboard the vessel:Bremen City of residence at time of declaration: Dorothy NJDeclaration submitted and sworn on date:28 November 1924
Towards Inducing Weight Perception in Virtual Reality Through a Liquid-based Haptic Controller
Creators: name: Kalus, Alexander
name: Kocur, Martin
name: Henze, Niels
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: virtual reality, haptic controllers, weight perception
subject: 004 Informatik

description: Rendering haptic sensations while interacting with virtual objects, such as experiencing weight is essential for creating natural virtual reality (VR) experiences. However, accurately providing the forces required to sense an object’s weight poses a demanding challenge. Hence, standard VR setups do not allow users to experience different weight sensations. In this paper, we propose a haptic VR controller design that renders the weight of virtual objects by regulating the mass of the controller through liquid transfer. Our planned system consists of two tracked controllers that contain a water bag. They are connected to a liquid reservoir in the back, to or from which water is transferred to change the weight of the controller. A Microcontroller determines the weight of each reservoir via a bi-directional water pump and a set of solenoid valves. To evaluate the prototype, we are planning to investigate in a study whether our system can enhance the VR experience and sense of presence while lifting and swinging virtual objects. Furthermore we plan to examine, whether the device can be used to amplify avatar embodiment.