Metadata record for the article: Crown-Like Structures in Breast Adipose Tissue of Breast Cancer Patients: Associations with CD68 Expression, Obesity, Metabolic Factors and Prognosis
Creators: name: Chang, Martin C.
name: Eslami, Zohreh
name: Ennis, Marguerite
name: Goodwin, Pamela J.
Publisher: name: figshare
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: <b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related article: “Crown-Like Structures in Breast Adipose Tissue of Breast Cancer Patients: Associations with CD68 Expression, Obesity, Metabolic Factors and Prognosis”. The related study examined associations of H&amp;E and CD68-detected crown-like structures of the breast (CLS-B) with clinicopathologic features using chi-squared tests, with metabolic factors using Wilcoxon rank sum tests and with disease free and overall survival using Cox regression models. Type of data: clinical data Subject of data: <i>Homo sapiens; </i>antibodies Sample size: 535 Population characteristics: The population comprised a consecutive cohort of women who underwent treatment for operable breast cancer at Mount Sinai Hospital (Toronto, Canada) between June 1989 and June 1996. Women were included if they had age less than 75 years, complete resection of breast cancer and axillary dissection for previously untreated breast cancer. Women were excluded if they had prior malignancy (except cervical in situ lesion or nonmelanoma skin cancer), a serious coexisting medical condition, including diabetes, use of medications that modified key study variables, or inability to provide consent. Recruitment: Consecutive women were recruited from those women undergoing surgery for breast cancer (see above). Women were excluded if they had prior malignancy (except cervical in situ lesion or nonmelanoma skin cancer), a serious coexisting medical condition, including diabetes, use of medications that modified key study variables, or inability to provide consent. No systematic source of bias was identified. <b>Data access</b> All data underlying the claims of the related article are contained in the tab-delimited text file ‘NRF database.txt’. These data are housed on institutional storage and are not publicly available in order to protect patient privacy, as no Ethics approval to share data was received. However, the data will be made available upon request to individual investigators. Data enquiries should be addressed to the corresponding author. <b>Corresponding author(s) for this study</b> Dr. Martin C. Chang, University of Vermont Medical Center, Department of Pathology &amp; Laboratory Medicine, Main Pavilion 1st Floor, 111 Colchester Avenue, Burlington, VT 05401. Martin.Chang@uvmhealth.org <br> <b>Study approval </b> Ethics oversight was provided by Mount Sinai Hospital, Toronto, Canada, Research Ethics Board. Informed consent was obtained from all participants for both the original prospective trial, and for the use of all data in future research-ethics-board-approved research.