cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
АНАЛИЗ ЖИЗНЕННОГО ЦИКЛА ОРГАНИЗАЦИИ В КОНТЕКСТЕ ОТРАСЛЕВОЙ И МАКРОЭКОНОМИЧЕСКОЙ ЦИКЛИЧНОСТИ
Creators: name: С. С. Маклакова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: бизнес-анализ
жизненный цикл организации
жизненный цикл отрасли
экономический цикл
отраслевая цикличность
макроэкономическая цикличность

description: В современном мире со сложной, противоречивой, динамичной внешней средой изучение жизненного цикла организации не должно проводиться обособленно от учета влияния на него отраслевой и макроэкономической цикличности. Принято считать, что развитие, динамика и смена фаз циклов более низкого уровня обуславливаются характеристиками циклов высокого уровня, однако такая зависимость далеко не всегда является прямо пропорциональной. Выявление основных индикаторов отраслевой и макроэкономической цикличности, влияющих на показатели эффективности деятельности организации (экономической, социальной и экологической), определение характера их влияния и постоянный мониторинг их изменений позволяют прогнозировать изменение финансового состояния организации, способности удовлетворять требования основных заинтересованных сторон, а также принимать своевременные обоснованные решений о необходимости изменений на всех стадиях жизненного цикла организации.
Evaluating the effectiveness of neoadjuvant chemotherapy in reducing mastectomy for women with breast cancer
Creators: name: Mohiuddin, J.J.
name: Marks, L.B.
name: Lund, J.L.
name: Jones, E.L.
name: Chen, R.C.
name: Zagar, T.M.
name: Deal, A.M.
name: Baker, B.R.
name: Carey, L.A.
Publisher: name: Oxford University Press
Year: 2017

description: Background: Neoadjuvant chemotherapy in breast cancer reduced mastectomy rates by 7% to 13% in randomized trials. However, the differential effects for women with different stages, receptor subtypes, and ages are unknown. We compared mastectomy rates in women who did vs did not receive neoadjuvant chemotherapy in 18 patient subgroups. The main objective was to quantify the potential benefit from neoadjuvant chemotherapy in reducing mastectomy rates for each subgroup. Methods: Our retrospective analysis used data from the National Cancer Data Base, which includes approximately 70% of incident cancers across the United States. Absolute risk reductions for mastectomy were determined for 18 subgroups of clinical stage, receptor subtype, and age group. In each subgroup, propensity score weighting balanced measured covariates between women treated with vs without neoadjuvant chemotherapy. Results: A total of 55 709 patients were analyzed. In clinical stage IIA disease, only patients with human epidermal growth factor receptor 2 (HER2)-positive tumors had reduced mastectomy rates associated with neoadjuvant chemotherapy (age < 60 years, 12%; age ≥ 60 years, 12.6%). For stage IIB cancers, neoadjuvant chemotherapy was associated with an absolute reduction in mastectomy rates of 5.9% in women younger than age 60 years with hormone receptor-positive/HER2- disease, 8.2% to 10.7% for triple-negative disease, and 11.7% to 17.4% for HER2+ disease. For stage IIIA, the reductions in mastectomy rates ranged from 6.6% to 15.9%. Conclusions: In an analysis of patients treated across the United States, we found that neoadjuvant chemotherapy was associated with a reduction in mastectomy rates to a similar magnitude overall as shown in randomized trials, but this benefit varied widely by patient subgroup. This study provides novel information to help women make informed decisions regarding treatment.
H ∞ and μ - synthesis Design of Coupled Tanks Level Control
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Eliyas Alemayehu
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, the design and analysis of coupled tank water level control system is done using robust
control theory. The main aim of this work is to improve level controlling mechanisms in industries and household
areas. In this paper, H ∞ and μ –synthesis controllers are designed to improve the level control system. The coupled
tank water level control system is designed using the proposed controller’s comparison and tested for tracking a
reference level signals (step, sine wave and random) and simulation results have been analyzed successfully. Finally
the comparative simulation results prove the effectiveness of the proposed coupled tank water level control system
with H ∞ controller for improving the tracking mechanism performance of the system
РЕФОРМИРОВАНИЕ ВНЕБИРЖЕВОГО РЫНКА ПФИ В РОССИИ
Creators: name: Н. А. Максимов
name: Е. В. Рябинина
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: производные финансовые инструменты
внебиржевой рынок
Банк России
центральный контрагент
маржирование сделок
Московская биржа
внебиржевые торговые платформы

description: В данной статье рассмотрены три реализуемые на данный момент Банком России направления реформирования внебиржевого рынка ПФИ в России: введение требования об осуществлении централизованного клиринга сделок, требования о маржировании сделок и требования о заключении сделок с использованием инфраструктуры биржи или через электронные торговые площадки. В статье анализируются параметры данных реформ, необходимость осуществления, а также их текущая стадия реализации.
Biodegradable and biocompatible alginate/gelatin/MXene composite membrane with efficient osteogenic activity and its application in guided bone regeneration
Creators: name: Qin, Xiaoli
name: Pan, Hongwei
name: Yang, Kefan
name: Xie, Weibo
name: Yang, Gaochuang
name: Wang, Jinqing
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Guided bone regeneration (GBR) utilizes a barrier membrane to maintain the osteogenic space and promote osseointegration of the implants. Developing a novel biomaterial to meet the mechanical and biological performance requirements of GBR membrane (GBRM) remains a huge challenge. Here, the sodium alginate (SA, S)/gelatin (G)/MXene (M) composite membrane (SGM) was prepared by combining sol-gel and freeze-drying processes. The incorporation of MXene improved the mechanical properties and hydrophilicity of the SA/G (SG) membrane, and also enhanced its cell proliferation and osteogenic differentiation. More importantly, when the concentration of MXene is 0.25%W/V, the SGM composite membrane exhibited the best tensile strength (40 MPa), high swelling rate (1012%), and appropriate degradation rate (40%). Meanwhile, the biological improvements were more significant. Therefore, the appropriate amount addition of MXene has a positive and obvious effect on the improvements of the mechanical properties, biocompatibility, and osteogenic induction of the SG composite membranes. This work provides a more extendable development idea for the application of SGM composite membrane as GBRM.
On Unification Modulo One-Sided Distributivity: Algorithms, Variants and Asymmetry
Creators: name: Marshall, Andrew M
name: Meadows, Catherine
name: Narendran, Paliath
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: An algorithm for unification modulo one-sided distributivity is an early result by Tidén and Arnborg. More recently this theory has been of interest in cryptographic protocol analysis due to the fact that many cryptographic operators satisfy this property. Unfortunately the algorithm presented in the paper, although correct, has recently been shown not to be polynomial time bounded as claimed. In addition, for some instances, there exist most general unifiers that are exponentially large with respect to the input size. In this paper we first present a new polynomial time algorithm that solves the decision problem for a non-trivial subcase, based on a typed theory, of unification modulo one-sided distributivity. Next we present a new polynomial algorithm that solves the decision problem for unification modulo one-sided distributivity. A construction, employing string compression, is used to achieve the polynomial bound. Lastly, we examine the one-sided distributivity problem in the new asymmetric unification paradigm. We give the first asymmetric unification algorithm for one-sided distributivity.
Intra-saccadic motion streaks as cues to linking object locations across saccades
Creators: name: Schweitzer, Richard
name: Rolfs, Martin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: 610 Medizin und Gesundheit

description: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: When visual objects shift rapidly across the retina, they produce motion blur. Intra-saccadic visual signals, caused incessantly by our own saccades, are thought to be eliminated at early stages of visual processing. Here we investigate whether they are still available to the visual system and could—in principle—be used as cues for localizing objects as they change locations on the retina. Using a high-speed projection system, we developed a trans-saccadic identification task in which brief but continuous intra-saccadic object motion was key to successful performance. Observers made a saccade to a target stimulus that moved rapidly either up or down, strictly during the eye movement. Just as the target reached its final position, an identical distractor stimulus appeared on the opposite side, resulting in a display of two identical stimuli upon saccade landing. Observers had to identify the original target using the only available clue: the target's intra-saccadic movement. In an additional replay condition, we presented the observers’ own intra-saccadic retinal stimulus trajectories during fixation. Compared to the replay condition, task performance was impaired during saccades but recovered fully when a post-saccadic blank was introduced. Reverse regression analyses and confirmatory experiments showed that performance increased markedly when targets had long movement durations, low spatial frequencies, and orientations parallel to their retinal trajectory—features that promote intra-saccadic motion streaks. Although the potential functional role of intra-saccadic visual signals is still unclear, our results suggest that they could provide cues to tracking objects that rapidly change locations across saccades.
Comparative toxicity and effectiveness of trastuzumab-based chemotherapy regimens in older women with early-stage breast cancer
Creators: name: Dusetzina, S.B.
name: Reeder-Hayes, K.E.
name: Carey, L.A.
name: Hinton, S.P.
name: Meng, K.
name: Meyer, A.M.
Publisher: name: American Society of Clinical Oncology
Year: 2017

description: Purpose The combination of chemotherapy and trastuzumab is the standard of care for adjuvant treatment of human epidermal growth factor receptor 2-positive breast cancer. Two regimens have been widely adopted in the United States: doxorubicin, cyclophosphamide, paclitaxel, and trastuzumab (ACTH) and docetaxel, carboplatin, and trastuzumab (TCH). No head-to-head comparison of these regimens has been conducted in a clinical trial, and existing trial data have limited generalizability to older patients. Methods We used SEER-Medicare data from 2005 to 2013 to compare outcomes of ACTH versus TCH among patients age older than 65 years. Propensity score matching was used to balance cohort characteristics between treatment arms. Outcomes included toxicity-related hospitalization, survival, and trastuzumab completion. Data from 1,077 patients receiving ACTH or TCH were analyzed, and the propensity-matched subsample included 416 women. Results There was a significant shift toward TCH over time, with 88% of patients receiving ACTH in 2005 compared with 15% by 2011. Among propensity score-matched patients, we found no difference between regimens in health care use overall or for chemotherapy-related adverse events (ACTH, 34% v TCH, 36.5%; P = .46). Patients receiving TCH were significantly more likely to complete trastuzumab (89% v 77%; P = .001). There was no difference in 5-year breast cancer-specific survival (ACTH, 92% v TCH, 96%; hazard ratio, 2.08; 95% CI, 0.90 to 4.82) or overall survival. Conclusion Among a matched sample of older patients, ACTH compared with TCH was not associated with a higher rate of serious adverse events or hospitalizations, but it was associated with less completion of adjuvant trastuzumab.Wedid not detect a difference in 5-year survival outcomes for ACTH compared with TCH. In the context of limited evidence in older patients, selection between these two regimens on the basis of concerns about differential toxicity or efficacy may not be appropriate.
title: Understanding future skills and enriching the skills debate
title: Deliverable 6.1. 2nd Report
titleType: AlternativeTitle
Creators: name: Kohlgrüber, Michael
name: Behrend, Clara
name: Götting, Adrian
name: Cuypers, Mathias
name: Warhurst, Chris
name: Wright, Sally
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Skill requirement
subject: Skill demand
subject: Skill categorisation
subject: Future skills
subject: Skill debate
subject: Competence
subject: Data availability
subject: Digital transformation
subject: Skill supply
subject: Future work
subject: 300
subject: Kompetenz
subject: Zukunft
subject: Digitalisierung

description: Deliverable 6.1 includes a framework for new or increasingly important skills within the digital transformation. This report updates an earlier version that was submitted in December 2019 and reflects progress and new insights. It includes results from a more detailed analysis of future skill demands performed within task 6.2 (which is based on a systematic literature review on skill needs for the digital transformation). These results were used to check and refine the skills ca- tegorisation developed in the first version of the report. Another progress was made within the chapter on the quantitative part of changes in skill demand (section 5) : The availability of data was reassessed by considering several further datasets.
ПРОБЛЕМЫ РАЗВИТИЯ ЭЛЕКТРОННОЙ КОММЕРЦИИ В УЗБЕКИСТАНЕ
Creators: name: Ш. Г. Маннанова
name: Д. Э. Ишанходжаева
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: электронная коммерция
большие данные
искусственный интеллект
интернет вещей
цифровые электронные платформы
облачные технологии
виртуальная реальность
дополнительная реальность
блокчейн
криптовaлюты

description: В данной статье рассмотрены актуальные вопросы развития электронной коммерции в Республике Узбекистан, а также вопросы подготовки высококвалифицированных кадров для развития электронной коммерции. Авторами определены основные направления подготовки кадров цифровой экономики, электронного бизнеса и цифровых платформ. Рассмотрены вопросы вовлечения в этот процесс высшие учебные заведения республики и основные направления обучения.
ОЦЕНКА ВЛИЯНИЯ ОФШОРИЗАЦИИ НА НАЦИОНАЛЬНУЮ ЭКОНОМИКУ
Creators: name: А. В. Мещерякова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: офшор
офшорная экономика
налоговые платежи
налоговая льгота
прибыль.

description: Проблема бегства капитала в офшорные юрисдикции актуальна, так как изымает большую часть национального капитала. Описаны основные методы оценки анализа бегства капитала. Выявлены несколько методик для расчета величины изъятого капитала из национальной экономики. Проведен анализ принимаемых мер по деофшоризации экономики и притоку национального капитала.
Design and Simulation of a Steam Turbine Generator using Observer Based and LQR Controllers
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Eliyas Alemayehu
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Steam turbine generator is an electromechanical system which converts heat energy to electrical energy.
In this paper, the modeling, design and analysis of a simple steam turbine generator have done using
Matlab/Simulink Toolbox. The open loop system have been analyzed to have an efficiency of 76.92 %. Observer
based & linear quadratic regulator (LQR) controllers have been designed to improve the generating voltage.
Comparison of this two proposed controllers have been done for increasing the performance improvement to
generate a 220 Dc volt. The simulation result shows that the steam turbine generator with observer based controller
has a small percentage overshoot with minimum settling time than the steam turbine generator with LQR controller
and the open loop system. Finally, the steam turbine generator with observer based controller shows better
improvement in performance than the steam turbine generator with LQR controller.
СИСТЕМА УПРАВЛЕНИЯ ОФШОРНОЙ ЭКОНОМИКОЙ
Creators: name: А. В. Мещерякова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: офшор
офшорная экономика
налоговые платежи
налоговая льгота
прибыль

description: Для предотвращения бегства капитала за рубеж важное значение отдается разработке системы мер по управлению офшорной экономикой. Описаны несколько подходов к разработке мер по деофшоризации национальной экономки. Выявлены важнейшие факторы формирования офшорных зон для привлечения иностранного капитала. Разработаны методики для деофшоризации экономки. Проведен анализ принимаемых мер по деофшоризации экономики и притоку национального капитала
ДИНАМИКА ПОТРЕБЛЕНИЯ ПРЕДМЕТОВ ДЛИТЕЛЬНОГО ПОЛЬЗОВАНИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ И ФЕДЕРАЛЬНЫХ ОКРУГАХ В КОНТЕКСТЕ ПРОБЛЕМ СОЦИАЛЬНОГО РАЗВИТИЯ
Creators: name: Ю. В. Мигунова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: домохозяйство
предметы длительного пользования
потребительские предпочтения
социальное развитие
динамика показателя

description: Целью статьи является исследование динамики потребления предметов длительного пользования в домохозяйствах Российской Федерации и ее регионах в период 2007, 2017 гг. Установлено, что данный показатель является определяющим вектором социального развития региона, отражающим потребительское поведение россиян в сложившихся социально-экономических условиях. Методологическую базу статьи составил анализ данных Росстата и социологических опросов. Результаты описывались по каждому конкретному товару.
Axillary Management of Stage II/III Breast Cancer in Patients Treated with Neoadjuvant Systemic Therapy: Results of CALGB 40601 (HER2-Positive) and CALGB 40603 (Triple-Negative)
Creators: name: Ollila, D.W.
name: Hudis, C.A.
name: Berry, D.A.
name: Cirrincione, C.T.
name: Winer, E.P.
name: Sikov, W.M.
name: Golshan, M.
name: Carey, L.A.
Publisher: name: Elsevier Inc.
Year: 2017

description: Background Management of the axilla in stage II/III breast cancer undergoing neoadjuvant systemic therapy (NST) is controversial. To understand current patterns of care, we collected axillary data from 2 NST trials: HER2-positive (Cancer and Leukemia Group B [CALGB] 40601) and triple-negative (CALGB 40603). Study Design Axillary evaluation pre- and post-NST was per the treating surgeon and could include sentinel node biopsy. Post-NST, node-positive patients were recommended to undergo axillary lymph node dissection (ALND). We report pre-NST histopathologic nodal evaluation and post-NST axillary surgical procedures with correlation to clinical and pathologic nodal status. Results Seven hundred and forty-two patients were treated, 704 had complete nodal data pre-NST and post-NST. Pre-NST, 422 (60%) of 704 patients underwent at least 1 procedure for axillary node evaluation (total of 468 procedures): fine needle aspiration (n = 234; 74% positive), core needle biopsy (n = 138; 72% positive), and sentinel node biopsy (n = 96; 33% positive). Pre-NST, 304 patients were considered node-positive. Post-NST, 304 of 704 patients (43%) underwent sentinel node biopsy; 44 were positive and 259 were negative (29 and 36 patients, respectively, had subsequent ALND). Three hundred and ninety-one (56%) patients went directly to post-NST ALND and 9 (1%) pre-NST node-positive patients had no post-NST axillary procedure. Post-NST, 170 (24%) of the 704 patients had residual axillary disease. Agreement between post-NST clinical and radiologic staging and post-NST histologic staging was strongest for node-negative (81%) and weaker for node-positive (N1 31%, N2 29%), with more than half of the clinically node-positive patients found to be pathologic negative (p < 0.001). Conclusions Our results suggest there is no widely accepted standard for axillary nodal evaluation pre-NST. Post-NST staging was highly concordant in patients with N0 disease, but poorly so in node-positive disease. Accurate methods are needed to identify post-NST patients without residual axillary disease to potentially spare ALND.
ИНСТРУМЕНТЫ РАЗВИТИЯ РОССИЙСКОЙ ЭКОНОМИКИ В РАМКАХ ПЕРЕХОДА К ШЕСТОМУ ТЕХНОЛОГИЧЕСКОМУ УКЛАДУ
Creators: name: Э. Р. Минасян
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: шестой технологический уклад
теория «волн»
интеллектуализация
роботизация
экологизация
нанотехнологии

description: Статья посвящена проблемам и перспективам экономического развития России в условиях перехода к шестому технологическому укладу. В работе использованы статистический, графический, аналитический, сравнительный методы исследования. Автором рассмотрены основополагающие долгосрочные тренды в рамках шестого технологического уклада: интеллектуализация, роботизация, экологизация производства, а также развитие энергетических технологий. Обозначена историческая ретроспектива технологического развития России и современное состояние. Исследованы основные барьеры, задачи. перспективы и центральные инструменты перехода нашей страны к шестому технологическому укладу.
Electron localization and optical absorption of polygonal quantum rings
Creators: name: Sitek, Anna
name: Serra, Llorenç
name: Gudmundsson, Vidar
name: Manolescu, Andrei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate theoretically polygonal quantum rings and focus mostly on the triangular geometry where the corner effects are maximal. Such rings can be seen as short core-shell nanowires, a generation of semiconductor heterostructures with multiple applications. We show how the geometry of the sample determines the electronic energy spectrum, and also the localization of electrons, with effects on the optical absorption. In particular, we show that irrespective of the ring shape low-energy electrons are always attracted by corners and are localized in their vicinity. The absorption spectrum in the presence of a magnetic field shows only two peaks within the corner-localized state domain, each associated with different circular polarization. This picture may be changed by an external electric field which allows previously forbidden transitions, and thus enables the number of corners to be determined. We show that polygonal quantum rings allow absorption of waves from distant ranges of the electromagnetic spectrum within one sample.
description: 10 pages, 12 figures
Identifiability and experimental design in perturbation studies
Creators: name: Gross, Torsten
name: Blüthgen, Nils
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: 570 Biologie

description: Motivation A common strategy to infer and quantify interactions between components of a biological system is to deduce them from the network’s response to targeted perturbations. Such perturbation experiments are often challenging and costly. Therefore, optimizing the experimental design is essential to achieve a meaningful characterization of biological networks. However, it remains difficult to predict which combination of perturbations allows to infer specific interaction strengths in a given network topology. Yet, such a description of identifiability is necessary to select perturbations that maximize the number of inferable parameters. Results We show analytically that the identifiability of network parameters can be determined by an intuitive maximum-flow problem. Furthermore, we used the theory of matroids to describe identifiability relationships between sets of parameters in order to build identifiable effective network models. Collectively, these results allowed to device strategies for an optimal design of the perturbation experiments. We benchmarked these strategies on a database of human pathways. Remarkably, full network identifiability was achieved, on average, with less than a third of the perturbations that are needed in a random experimental design. Moreover, we determined perturbation combinations that additionally decreased experimental effort compared to single-target perturbations. In summary, we provide a framework that allows to infer a maximal number of interaction strengths with a minimal number of perturbation experiments. Availability and implementation IdentiFlow is available at github.com/GrossTor/IdentiFlow. Supplementary information Supplementary data are available at Bioinformatics online.
Deconfinement Transition at High Isospin Chemical Potential and Low Temperature
Creators: name: Cohen, Thomas D.
name: Sen, Srimoyee
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We consider QCD with two degenerate flavors of light quarks(up and down) at asymptotically high isospin chemical potential with zero baryon chemical potential and calculate for the first time a quantitative expression for the critical temperature of the deconfinement transition in this regime. At high isospin chemical potential and sufficiently low temperatures this theory becomes equivalent to a pure Yang-Mills theory and accordingly has a first order deconfinement phase transition. Although this was conjectured in a seminal paper by Son and Stephanov in the year 2001, the critical temperature of this deconfinement phase transition was not computed. This paper computes the energy scale associated with this transition as a function of the isospin chemical potential by relating the parameters of the equivalent Yang-Mills theory to those of the underlying theory. We also relate the equation of state in one strongly interacting regime of QCD namely at finite isospin density to that in pure Yang-Mills, with the latter being amenable to straightforward numerical calculation. Our results for the critical temperature of deconfinement transition can be compared with future lattice calculations.
description: Added corrections to the speed of Goldstone modes and rephrased abstract
Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment
Creators: name: McLeod, H.L.
name: Deal, A.M.
name: Hertz, D.L.
name: Walko, C.M.
name: Irvin, W.J., Jr.
name: Jones, D.R.
name: Van Wieren, E.
name: Desta, Z.
name: Ibrahim, J.G.
name: Weck, K.E.
name: Marcath, L.A.
name: Danko, W.
name: Carey, L.A.
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Objectives Tamoxifen bioactivation to endoxifen is mediated primarily by CYP2D6; however, considerable variability remains unexplained. Our aim was to perform a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen concentrations. Patients and methods Comprehensive genotyping of CYP enzymes and transporters was performed using the iPLEX ADME PGx Pro Panel in 302 tamoxifen-treated breast cancer patients. Predicted activity phenotype for 19 enzymes and transporters were analyzed for univariate association with endoxifen concentration, and then adjusted for CYP2D6 and clinical covariates. Results In univariate analysis, higher activity of CYP2C8 (regression β=0.22, P=0.020) and CYP2C9 (β=0.20, P=0.04), lower body weight (β=-0.014, P<0.0001), and endoxifen measurement during winter (each β< -0.39, P=0.002) were associated with higher endoxifen concentrations. After adjustment for the CYP2D6 diplotype, weight, and season, CYP2C9 remained significantly associated with higher concentrations (P=0.02), but only increased the overall model R2 by 1.3%. Conclusion Our results further support a minor contribution of CYP2C9 genetic variability toward steadystate endoxifen concentrations. Integration of clinician and genetic variables into individualized tamoxifen dosing algorithms would marginally improve their accuracy and potentially enhance tamoxifen treatment outcomes.
Second Landau Level Fractional Quantum Hall Effects in the Corbino Geometry
Creators: name: Schmidt, B. A.
name: Bennaceur, K.
name: Bilodeau, S.
name: Gervais, G.
name: Pfeiffer, L. N.
name: West, K. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: For certain measurements, the Corbino geometry has a distinct advantage over the Hall and van der Pauw geometries, in that it provides a direct probe of the bulk 2DEG without complications due to edge effects. This may be important in enabling detection of the non-Abelian entropy of the 5/2 fractional quantum Hall state via bulk thermodynamic measurements. We report the successful fabrication and measurement of a Corbino-geometry sample in an ultra-high mobility GaAs heterostructure, with a focus on transport in the second and higher Landau levels. In particular, we report activation energy gaps of fractional quantum Hall states, with all edge effects ruled out, and extrapolate the conductivity prefactor from the Arrhenius fits. Our results show that activated transport in the second Landau level remains poorly understood. The development of this Corbino device opens the possibility to study the bulk of the 5/2 state using techniques not possible in other geometries.
ТЕНДЕНЦИИ РАЗВИТИЯ КЛЮЧЕВЫХ ОТРАСЛЕЙ РАСТЕНИЕВОДСТВА В АЛТАЙСКОМ КРАЕ
Creators: name: А. В. Миненко
name: М. В. Селиверстов
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: сельское хозяйство
посевные площади
погодные условия
объем производства
высокоэффективные технологии

description: В статье проведен анализ развития ключевых отраслей растениеводства Алтайского крае. Указаны сложности, возникавшие при проведении весеннее полевых работ. Представлен объем производства, его доля и место среди регионов РФ. Определены лидирующие районы в растениеводческой отрасли АПК края. Дана оценка внедрения и применения высокоэффективных технологий в хозяйствах АПК края. Представлено количество техники использующей навигацию. Представлены результаты использования современных технологий.
The isospin quartic term in the kinetic energy of neutron-rich nucleonic matter
Creators: name: Cai, Bao-Jun
name: Li, Bao-An
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The energy of a free gas of neutrons and protons is well known to be approximately isospin parabolic with a negligibly small quartic term of only $0.45$ MeV at the saturation density of nuclear matter $ρ_0=0.16/\rm{fm}^3$. Using an isospin-dependent single-nucleon momentum distribution including a high (low) momentum tail (depletion) with its shape parameters constrained by recent high-energy electron scattering and medium-energy nuclear photodisintegration experiments as well as the state-of-the-art calculations of the deuteron wave function and the equation of state of pure neutron matter near the unitary limit within several modern microscopic many-body theories, we show for the first time that the kinetic energy of interacting nucleons in neutron-rich nucleonic matter has a significant quartic term of $7.18\pm2.52\,\rm{MeV}$. Such a large quartic term has significant ramifications in determining the equation of state of neutron-rich nucleonic matter using both terrestrial and astrophysical observables.
description: Discussions and references added. Version accepted as a Rapid Communication in PRC
Another breast cancer entity confirmed: Genomics of invasive lobular breast cancer
Creators: name: Gatza, M.L.
name: Carey, L.A.
Publisher: name: American Society of Clinical Oncology
Year: 2016

description: Invasive lobular carcinoma (ILC) accounts for up to 15% of all invasive breast cancers. We have long recognized the unique clinical characteristics of ILC, but an increased understanding of its biology in contrast with the more common breast cancer histologic type, infiltrating ductal carcinoma (IDC), has emerged. The article that accompanies this editorial by Desmedt et al reinforces and extends this understanding.
Untitled Item
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Eliyas Alemayehu
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper a NARMA L2, model reference and neural network predictive controller is utilized in order
to control the output flow rate of the steam in furnace by controlling the steam flow valve. The steam flow control
system is basically a feedback control system which is mostly used in cement production industries. The design of
the system with the proposed controllers is done with Matlab/Simulink toolbox. The system is designed for the
actual steam flow output to track the desired steam that is given to the system as input for two desired steam input
signals (step and sine wave). In order to analyze the performance of the system, comparison of the proposed
controllers is done by simulating the system for the two reference signals for the system with and without sensor
noise disturbance. Finally the comparison results prove the effectiveness of the presented process control system
with model reference controller
Neoadjuvant Systemic Therapy Use for Younger Patients with Breast Cancer Treated in Different Types of Cancer Centers Across the United States
Creators: name: Marks, L.B.
name: Deal, A.M.
name: Zagar, T.M.
name: Lund, J.L.
name: Mohiuddin, J.J.
name: Carey, L.A.
name: Chen, R.C.
name: Jones, E.L.
name: Baker, B.R.
Publisher: name: Elsevier Inc.
Year: 2016

description: Background Multiple clinical trials have shown that neoadjuvant systemic therapy has a benefit in women who are borderline lumpectomy candidates and in those with locally advanced breast cancers by reducing the mastectomy rate and making inoperable tumors operable. The study aim was to examine the patterns of neoadjuvant chemotherapy and endocrine therapy use among younger women in the United States treated at different types of cancer centers. Study Design Data from the National Cancer Data Base for 118,086 women younger than 65 years with clinical stage IIA (T2N0 only) to IIIC breast cancer. Following the National Comprehensive Cancer Network guideline categorization, patients were grouped into those who were borderline lumpectomy candidates (clinical stage IIA [T2N0 only], IIB, or IIIA [T3N1 only]) or those with locally advanced disease (clinical stage IIIA [T0-3N2 only], IIIB, or IIIC). The main outcome was the proportion of women who received neoadjuvant systemic therapy. Results Use of neoadjuvant chemotherapy ranged from 17% (stage IIA) to 79% (stage IIIB). Across almost all stage and receptor subtypes, the use was lower in community vs academic centers. On multivariable analysis, use of neoadjuvant chemotherapy was decreased in community vs academic centers (borderline lumpectomy candidates: adjusted risk ratio = 0.73; 95% CI, 0.69–0.77; locally advanced disease: adjusted risk ratio = 0.78; 95% CI, 0.74–0.83). Conclusions Use of guideline-concordant neoadjuvant chemotherapy is significantly higher among women treated at academic vs community centers in young and healthy women who do not commonly have contraindications to this treatment. Our study identified a potential disparity in cancer care by type of center where patients receive treatment.
Foveal vision anticipates defining features of eye movement targets
Creators: name: Kroell, Lisa
name: Rolfs, Martin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: 150 Psychologie

description: The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: High-acuity foveal processing is vital for human vision. Nonetheless, little is known about how the preparation of large-scale rapid eye movements (saccades) affects visual sensitivity in the center of gaze. Based on findings from passive fixation tasks, we hypothesized that during saccade preparation, foveal processing anticipates soon-to-be fixated visual features. Using a dynamic large-field noise paradigm, we indeed demonstrate that defining features of an eye movement target are enhanced in the pre-saccadic center of gaze. Enhancement manifested as higher Hit Rates for foveal probes with target-congruent orientation and a sensitization to incidental, target-like orientation information in foveally presented noise. Enhancement was spatially confined to the center of gaze and its immediate vicinity, even after parafoveal task performance had been raised to a foveal level. Moreover, foveal enhancement during saccade preparation was more pronounced and developed faster than enhancement during passive fixation. Based on these findings, we suggest a crucial contribution of foveal processing to trans-saccadic visual continuity: Foveal processing of saccade targets commences before the movement is executed and thereby enables a seamless transition once the center of gaze reaches the target.
МАРКЕТИНГОВАЯ ДЕЯТЕЛЬНОСТЬ ФИТНЕС СТУДИИ
Creators: name: А. В. Мусий
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: спортивный маркетинг
управление
фитнес организация

description: В данной статье рассматривается роль маркетинга в деятельности организаций фитнес индустрии. Сегодня эффективная маркетинговая деятельность фитнес организации обеспечивает львиную долю ее успеха. Тем не менее, не все организации в сфере фитнеса осуществляют активную работу в данном направлении из-за недостаточного понимания системы организации маркетинга. В этой статье описаны способы повышения эффективности деятельности фитнес организации за счет маркетинговой деятельности, а также приведены конкретные инструменты, позволяющие организовать эффективную маркетинговую деятельность в сфере фитнеса
Thermophotovoltaic conversion efficiency measurement at high view factors
Creators: name: López, Esther
name: Artacho, Irene
name: Datas, Alejandro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: A standardized method for measuring thermophotovoltaic (TPV) efficiency has not been yet established, which makes the reported results difficult to compare. Besides, most of the TPV efficiencies reported to date have been obtained using small view factors, i.e., large cell-to-emitter distances, so the impact of the series resistance is usually underestimated, and the optical cavity effects, i.e., the multiple reflections taking place between the emitter and the cell, are not accounted for experimentally. In this work, we present an experimental setup able to measure the TPV efficiency under high view factors (up to 0.98), by using small emitter-to-cell distances (< 1 mm). This allows a more accurate direct measurement of the TPV efficiency at higher power densities than previous works. As a result, a TPV efficiency of 26.4+-0.1 % and a power density of 4.3+-0.8 W/cm2 have been obtained for an InGaAs TPV cell with a back surface reflector irradiated by a graphite thermal emitter at 1592 C.
I-SPY 2 - Toward more rapid progress in breast cancer treatment
Creators: name: Winer, E.P.
name: Carey, L.A.
Publisher: name: Massachussetts Medical Society
Year: 2016

description: Clinical trials of systemic therapy for operable breast cancer are evolving. Our understanding of breast cancer as a family of biologically distinct diseases has implications for patient selection and the optimization of drug choices. In addition, there is a growing dissatisfaction with trials of adjuvant therapy that are large, take many years to complete, and often result in very small improvements in outcome. For these reasons, we must be thoughtful and rigorous in focusing the testing of promising agents in patients who could derive a meaningful benefit. These realities are in part responsible for the explosion of “neoadjuvant,” or preoperative, trials of systemic therapy in breast cancer. Neoadjuvant therapy, by virtue of the intermediate end point of complete tumor eradication before surgery (called pathological complete response), allows new regimens to be tested in much smaller trials and for results to be obtained far more rapidly than in adjuvant studies.
ГОСУДАРСТВЕННЫЙ (ФИНАНСОВЫЙ) КОНТРОЛЬ КАК ИНСТРУМЕНТ УПРАВЛЕНЧЕСКОЙ ФУНКЦИИ ГОСУДАРСТВА
Creators: name: Р. Ф. Мухаметшин
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: государственное управление
государственный контроль
финансовый контроль
национальные проекты
государство
функции государственного управления.

description: В данной статье рассмотрена важнейшая функция в государственном управлении – финансовый контроль. Также описываются понятия, виды и функции финансового контроля. В статье обозначается увеличение роли финансового контроля в деятельности государства, в связи с колоссальным вливанием бюджетных средств в экономику страны в рамках национальных проектов. Проведено исследование по повышению результативности финансового контроля как функции государственного управления для достижения поставленных целей государства
К ВОПРОСУ О ПРОБЛЕМАХ РОССИЙСКОГО РЫНКА ТРУДА
Creators: name: С. В. Назарова
name: Р. Р. Атаев
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: российский рынок труда
безработица
уровень безработицы
занятость
регистрируемая и общая безработицы

description: В данной статье рассмотрены аспекты, связанные с современными проблемами и особенностями российского рынка труда. Проанализированы причины существующего значительного разрыва между регистрируемой и общей безработицей. Рассмотрена проблема наличия диспропорций в уровнях безработицы по различным отраслям и регионам России. Проанализированы меры, предпринимаемые государством для стабилизации рынка труда. Затронута проблема перспективного роста технологической безработицы вследствие модернизации производства в России
PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline-and taxane-based chemotherapy: Correlative analysis of C9741 (alliance)
Creators: name: Winer, E.P.
name: Reed, J.P.
name: Deschryver, K.
name: Singh, B.
name: Barry, W.T.
name: Ellis, M.J.
name: Davies, S.R.
name: Pitcher, B.N.
name: Bernard, P.S.
name: Snider, J.E.
name: Friedman, P.N.
name: Liu, M.C.
name: Perez, E.A.
name: Carey, L.A.
name: Hudis, C.A.
name: Citron, M.L.
name: Nielsen, T.O.
name: Martino, S.
name: Mardis, E.R.
name: Vickery, T.L.
name: Perou, C.M.
name: Gradishar, W.J.
name: Norton, L.
Publisher: name: Nature Publishing Group
Year: 2016

description: PAM50 intrinsic breast cancer subtypes are prognostic independent of standard clinicopathologic factors. CALGB 9741 demonstrated improved recurrence-free (RFS) and overall survival (OS) with 2-weekly dose-dense (DD) versus 3-weekly therapy. A significant interaction between intrinsic subtypes and DD-therapy benefit was hypothesized. Suitable tumor samples were available from 1,471 (73%) of 2,005 subjects. Multiplexed gene-expression profiling generated the PAM50 subtype call, proliferation score, and risk of recurrence score (ROR-PT) for the evaluable subset of 1,311 treated patients. The interaction between DD-therapy benefit and intrinsic subtype was tested in a Cox proportional hazards model using two-sided alpha = 0.05. Additional multivariable Cox models evaluated the proliferation and ROR-PT scores as continuous measures with selected clinical covariates. Improved outcomes for DD therapy in the evaluable subset mirrored results from the complete data set (RFS; hazard ratio = 1.20; 95% confidence interval = 0.99–1.44) with 12.3-year median follow-up. Intrinsic subtypes were prognostic of RFS (P<0.0001) irrespective of treatment assignment. No subtype-specific treatment effect on RFS was identified (interaction P = 0.44). Proliferation and ROR-PT scores were prognostic for RFS (both P<0.0001), but no association with treatment benefit was seen (P = 0.14 and 0.59, respectively). Results were similar for OS. The prognostic value of PAM50 intrinsic subtype was greater than estrogen receptor/HER2 immunohistochemistry classification. PAM50 gene signatures were highly prognostic but did not predict for improved outcomes with DD anthracycline-and taxane-based therapy. Clinical validation studies will assess the ability of PAM50 and other gene signatures to stratify patients and individualize treatment based on expected risks of distant recurrence.
ПРОГНОЗЫ РАЗВИТИЯ ЦИФРОВОЙ ЭКОНОМИКИ В РОССИИ
Creators: name: М. В. Осадчая
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: цифровая экономика
технологии
оптимизация
бережливое производство
цифровой двойник
цифровые платформы

description: В данной статье исследуется проблема развития цифровой экономики в России, которая приобрела государственное значение. Большое место в работе занимает рассмотрение комплекса мер по стимулированию и поддержке цифровизации, принятых Российским Правительством. Внимание обращается на изучение целевых показателей паспорта национальной программы «Цифровая экономика». В статье на основе анализа выясняется, что в России существует значительное цифровое неравенство, отставание местной инфраструктуры. Также, исследование показало, что залогом успеха цифровой трансформации экономики и общества должен стать процесс цифровой трансформации государства.
Modern GPR Target Recognition Methods
Creators: name: Giovanneschi, Fabio
name: Mishra, Kumar Vijay
name: Gonzalez-Huici, Maria Antonia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Signal Processing (eess.SP)
subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Traditional GPR target recognition methods include pre-processing the data by removal of noisy signatures, dewowing (high-pass filtering to remove low-frequency noise), filtering, deconvolution, migration (correction of the effect of survey geometry), and can rely on the simulation of GPR responses. The techniques usually suffer from the loss of information, inability to adapt from prior results, and inefficient performance in the presence of strong clutter and noise. To address these challenges, several advanced processing methods have been developed over the past decade to enhance GPR target recognition. In this chapter, we provide an overview of these modern GPR processing techniques. In particular, we focus on the following methods: adaptive receive processing of range profiles depending on the target environment; adoption of learning-based methods so that the radar utilizes the results from prior measurements; application of methods that exploit the fact that the target scene is sparse in some domain or dictionary; application of advanced classification techniques; and convolutional coding which provides succinct and representatives features of the targets. We describe each of these techniques or their combinations through a representative application of landmine detection.
description: Book chapter, 56 pages, 17 figures, 12 tables. arXiv admin note: substantial text overlap with arXiv:1806.04599