cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Can molecular projected density-of-states (PDOS) be systematically used in electronic conductance analysis?
Creators: name: Rangel, Tonatiuh
name: Rignanese, Gian-Marco
name: Olevano, Valerio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using benzene-diamine and benzene-dithiol molecular junctions as benchmarks, we investigate the widespread analysis of the quantum transport conductance $\mathcal{G}(ε)$ in terms of the projected density of states (PDOS) onto molecular orbitals (MOs). We first consider two different methods for identifying the relevant MOs: 1) diagonalization of the Hamiltonian of the isolated molecule, and 2) diagonalization of a submatrix of the junction Hamiltonian constructed by considering only basis elements localized on the molecule. We find that these two methods can lead to substantially different MOs and hence PDOS. Furthermore, within Method 1, the PDOS can differ depending on the isolated molecule chosen to represent the molecular junction (e.g. benzene-dithiol or -dithiolate); and, within Method 2, the PDOS depends on the chosen basis set. We show that these differences can be critical when the PDOS is used to provide a physical interpretation of the conductance (especially, when it has small values as it happens typically at zero bias). In this work, we propose a new approach trying to reconcile the two traditional methods. Though some improvements are achieved, the main problems are still unsolved. Our results raise more general questions and doubts on a PDOS-based analysis of the conductance.
description: 12 pages, 9 figures
(4150) Thomas Hardwick
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision
Creators: name: Chen, Y.
name: Dotti, G.
name: Zheng, M.
name: Savoldo, B.
name: Wang, K.
name: Landoni, E.
name: Ahn, S.
name: Han, Z.
Publisher: name: Nature Research
Year: 2020

description: Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2. Although it is treatable in patients with early diagnosis, patients may lose one or two eyes. We generated GD2-specific chimeric antigen receptor T lymphocytes (GD2.CAR-Ts) and locally delivered them to mice with an in situ grafting RB. We showed that, when used in combination with the local release of interleukin-15 and an injectable hydrogel, GD2.CAR-Ts successfully eliminate RB tumor cells without impairing mouse vision.
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Creators: name: DeRenzo, C.
name: Sanber, K.
name: Gerken, C.
name: Joseph, S.K.
name: Hicks, J.
name: Robertson, C.
name: Mehta, B.
name: Byrd, T.T.
name: Dakhova, O.
name: Hegde, M.
name: Wels, W.S.
name: Zhang, H.
name: Gee, A.
name: Brenner, M.K.
name: Salsman, V.S.
name: Heslop, H.E.
name: Shree, A.
name: Kalra, M.
name: Pashankar, F.
name: Ahmed, N.
name: Dotti, G.
name: Xu, M.L.
name: Grilley, B.
name: Navai, S.
name: Gottschalk, S.
Publisher: name: Nature Research
Year: 2020

description: Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to autologous HER2 CAR T cells. Three cycles of HER2 CAR T cells given after lymphodepleting chemotherapy induces remission which is consolidated with four more CAR T-cell infusions without lymphodepletion. Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins. The disease relapses in the bone marrow at six months off-therapy. A second remission is achieved after one cycle of lymphodepletion and HER2 CAR T cells. Response consolidation with additional CAR T-cell infusions includes pembrolizumab to improve their efficacy. The patient described here is a participant in an ongoing phase I trial (NCT00902044; active, not recruiting), and is 20 months off T-cell infusions with no detectable disease at the time of this report.
Convergence of Mayer and Virial expansions and the Penrose tree-graph identity
Creators: name: Procacci, Aldo
name: Yuhjtman, Sergio A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 82B21

description: We establish new lower bounds for the convergence radius of the Mayer series and the Virial series of a continuous particle system interacting via a stable and tempered pair potential. Our bounds considerably improve those given by Penrose and Ruelle in 1963 for the Mayer series and by Lebowitz and Penrose in 1964 for the Virial series. To get our results we exploit the tree-graph identity given by Penrose in 1967 using a new partition scheme based on minumum spanning trees.
description: Final version, to be published in Letters in Mathematical Physics
(4152) Basil Mortimer Iles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Artibeus inopinatus W. B. Davis & D. C. Carter 1964
Creators: name: Wilson, Don E.
name: Mittermeier, Russell A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Phyllostomidae
Artibeus
Artibeus inopinatus

description: 188. Honduran Fruit-eating Bat Artibeus inopinatus French: Artibée du Honduras / German: Honduras-Fruchtvampir / Spanish: Artibeo hondureno Taxonomy. Artibeus inopinatus W. B. Davis & D. C. Carter, 1964. “ Choluteca, 10 ft [= 3 m], Depto. de Choluteca, Honduras.” Artibeus inopinatus is in subgenus Artibeus. Although usually considered closer to A. har sutus, molecular analyses suggested that A. inopinatus is sister to the clade A. harsutus + A. fraterculus. Monotypic. Distribution. Pacific slopes of Central America, from El Salvador to Nicaragua. Descriptive notes. Forearm 48-49 mm (males) and 51-53 mm (females); weight 24-7-35-9 g. Other measurements are not available. The Honduran Fruit-eating Bat is seemingly most closely allied to the Hairy Fruit-eating Bat (A. hirsutus) ofwestern Mexico, but it is smaller, and its uropatagium is less hairy, although it has noticeable fringe of hairs on its free edge. Upperparts are pale gray, with tips of hairs frosted whitish; fur is very short and velvety. Whitish facial stripes are faint; lower ones are sometimes absent. Ventral fur is slightly paler than dorsum. Muzzle is short and broad. Dental formula is I 2 /2, C1/1,P 2/2. M 3/3 (x2) = 32. Unlike the Hairy Fruit-eating Bat, the Honduran Fruiteating Bat lacks broad spine on posterior border of palate that projects into interpterygoid space. Chromosomal complement has 2n = 31 (males) or 30 (females) and FN = 56. X-chromosome and Y-chromosome are subtelocentric, and Y,chromosome Is acrocentric. Habitat. Dry thorn-scrub habitats, banana groves, and deciduousforests from lowlands to elevations of ¢. 1100 m. Food and Feeding. No information. Breeding. Pregnant Honduran Fruit-eating Bats were found in May in Honduras and lactating females in May and July in El Salvador and Honduras. Juveniles were caught in August in Honduras and Nicaragua. In Nicaragua, males were found with descended testes in June. Activity patterns. A small group of Honduran Fruit-eating Bats with one male, eight females, and five young was found roosting in a building. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Data Deficient on The IUCN Red List. Additional information on population status and life history of the Honduran Fruit-eating Bat is needed to understand its conservation threats. Bibliography. Davis & Carter (1964), Larsen et al. (2013), Medina-Fitoria (2014), Reid & Medina-Fitoria (2016), Webster & Jones (1983).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Phyllostomidae, pp. 444-583 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on page 571, DOI: 10.5281/zenodo.6458594
Non-Local Advantage of Quantum Coherence
Creators: name: Mondal, Debasis
name: Pramanik, Tanumoy
name: Pati, Arun Kumar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A bipartite state is said to be steerable if and only if it does not have a single system description, i.e., the bipartite state cannot be explained by a local hidden state model. Several steering inequalities have been derived using different local uncertainty relations to verify the ability to control the state of one subsystem by the other party. Here, we derive complementarity relations between coherences measured on mutually unbiased bases using various coherence measures such as the $l_1$-norm, relative entropy and skew information. Using these relations, we derive conditions under which non-local advantage of quantum coherence can be achieved and the state is steerable. We show that not all steerable states can achieve such advantage.
description: 8 pages, protocol modified, To appear in PRA-Rapid Communications
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
Creators: name: Liu, D.
name: Liu, C.
name: Jiang, J.-G.
name: Fritzky, L.
name: Badeti, S.
name: Xiong, W.
name: Tseng, H.-C.
name: Ramos, C.A.
name: Ma, M.
name: Yi, Q.
name: Yang, Y.
name: Zong, W.-X.
name: Dotti, G.
name: Liu, T.
name: Guarrera, J.
Publisher: name: Nature Research
Year: 2020

description: Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for treating multiple refractory blood cancers, but further advances are required for solid tumor CAR therapy. One challenge is identifying a safe and effective tumor antigen. Here, we devise a strategy for targeting hepatocellular carcinoma (HCC, one of the deadliest malignancies). We report that T and NK cells transduced with a CAR that recognizes the surface marker, CD147, also known as Basigin, can effectively kill various malignant HCC cell lines in vitro, and HCC tumors in xenograft and patient-derived xenograft mouse models. To minimize any on-target/off-tumor toxicity, we use logic-gated (log) GPC3–synNotch-inducible CD147-CAR to target HCC. LogCD147-CAR selectively kills dual antigen (GPC3+CD147+), but not single antigen (GPC3-CD147+) positive HCC cells and does not cause severe on-target/off-tumor toxicity in a human CD147 transgenic mouse model. In conclusion, these findings support the therapeutic potential of CD147-CAR-modified immune cells for HCC patients.
An Improved Image Mosaicing Algorithm for Damaged Documents
Creators: name: Dhokley, Waheeda
name: Munifa, Khan
name: Nazia, Shaikh
name: Saiqua, Shaikh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: It is a common phenomenon in day to day life; where in some of the document gets damaged. Out of several reasons, the main reason for documents getting damaged is shredding by hands. Recovery of such documents is essential. Manual recovery of such damaged document is tedious and time consuming task. In this paper, we are describing an algorithm which recovers the original document from such shredded pieces of the same. In order to implement this, we are using a simple technique called Image Mosaicing. In this technique a complete new image is developed using two or more torn fragments. For simplicity of implementation, we are considering only two torn pieces of a document that will be mosaiced together. The successful implementation of this algorithm would lead to recovery of important information which in turn would be beneficial in various fields such as forensic sciences, archival study, etc
description: 6 pages, 10 figures
Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis
Creators: name: Montalbano, A.
name: Liu, B.
name: Liu, K.
name: Savoldo, B.
name: Li, M.
name: Dakhova, O.
name: Ngai, H.
name: Courtney, A.N.
name: Chauvin-Fleurence, C.N.
name: Robinson, S.
name: Metelitsa, L.S.
name: Dotti, G.
name: Xu, X.
name: Di Pierro, E.J.
name: Raveh-Sadka, T.
name: Heczey, A.
name: Ghatwai, N.
Publisher: name: Nature Research
Year: 2020

description: Vα24-invariant natural killer T (NKT) cells have shown potent anti-tumor properties in murine tumor models and have been linked to favorable outcomes in patients with cancer. However, low numbers of these cells in humans have hindered their clinical applications. Here we report interim results from all three patients enrolled on dose level 1 in a phase 1 dose-escalation trial of autologous NKT cells engineered to co-express a GD2-specific chimeric antigen receptor (CAR) with interleukin-15 in children with relapsed or resistant neuroblastoma (NCT03294954). Primary and secondary objectives were to assess safety and anti-tumor responses, respectively, with immune response evaluation as an additional objective. We ex vivo expanded highly pure NKT cells (mean ± s.d., 94.7 ± 3.8%) and treated patients with 3 × 106 CAR-NKT cells per square meter of body surface area after lymphodepleting conditioning with cyclophosphamide/fludarabine (Cy/Flu). Cy/Flu conditioning was the probable cause for grade 3–4 hematologic adverse events, as they occurred before CAR-NKT cell infusion, and no dose-limiting toxicities were observed. CAR-NKT cells expanded in vivo, localized to tumors and, in one patient, induced an objective response with regression of bone metastatic lesions. These initial results suggest that CAR-NKT cells can be expanded to clinical scale and safely applied to treat patients with cancer.
Physical Layer Security for Massive MIMO: An Overview on Passive Eavesdropping and Active Attacks
Creators: name: Kapetanovic, Dzevdan
name: Zheng, Gan
name: Rusek, Fredrik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This article discusses opportunities and challenges of physical layer security integration in massive multiple-input multiple-output (MaMIMO) systems. Specifically, we first show that MaMIMO itself is robust against passive eavesdropping attacks. We then review a pilot contamination scheme which actively attacks the channel estimation process. This pilot contamination attack is not only dramatically reducing the achievable secrecy capacity but is also difficult to detect. We proceed by reviewing some methods from literature that detect active attacks on MaMIMO. The last part of the paper surveys the open research problems that we believe are the most important to address in the future and give a few promising directions of research to solve them.
description: 5 figures, to appear in IEEE Communications Magazine 2015, special issue on Wireless Physical Layer Security
(4147) Eliza Hawksworth
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Resonant inelastic x-ray scattering as a probe of band structure effects in cuprates
Creators: name: Kanász-Nagy, Márton
name: Shi, Yifei
name: Klich, Israel
name: Demler, Eugene A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We analyze within quasi-particle theory a recent resonant inelastic x-ray scattering (RIXS) experiment on $\mathrm{YBa_2Cu_3O_{6+x}}$ with the incoming photon energy detuned at several values from the resonance maximum [Minola et al., Phys. Rev. Lett. 114, 217003 (2015)]. Surprisingly, the data shows much weaker dependence on detuning than expected from recent measurements on a different cuprate superconductor, $\mathrm{Bi_2Sr_2CuO_{6+x}}$ [Guarise et al., Nat. Commun. 5, 5760 (2014)]. We demonstrate here, that this discrepancy, originally attributed to collective magnetic excitations, can be understood in terms of the differences between the band structures of these materials. We find good agreement between theory and experiment over a large range of dopings, both in the underdoped and in the overdoped regime. Moreover, we demonstrate that the RIXS signal depends sensitively on excitations at energies well above the Fermi surface, that are inaccessible to traditionally used band structure probes, such as angle-resolved photemisson spectroscopy. This makes RIXS a powerful probe of band structure, not suffering from surface preparation problems and small sample sizes, making it potentially applicable to a number of cuprate materials.
(4148) Thomas Plint
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces
Creators: name: Dotti, G.
name: Liu, L.
name: Yun, Y.
name: Aravamudhan, S.
name: Russell, T.
name: Dirar, Q.
name: Conforti, L.
name: Ahn, S.
Publisher: name: Public Library of Science
Year: 2020

description: Adoptive cell transfer of Chimeric Antigen Receptor (CAR)-T cells showed promising results in patients with B cell malignancies. However, the detailed mechanism of CAR-T cell interaction with the target tumor cells is still not well understood. This work provides a systematic method for analyzing the activation and degranulation of second-generation CAR-T cells utilizing antigen-presenting cell surfaces. Antigen-presenting cell surfaces composed of circular micropatterns of CAR-specific anti-idiotype antibodies have been developed to mimic the interaction of CAR-T cells with target tumor cells using micro-contact printing. The levels of activation and degranulation of fixed non-transduced T cells (NT), CD19.CAR-T cells, and GD2.CAR-T cells on the antigen-presenting cell surfaces were quantified and compared by measuring the intensity of the CD3ζ chain phosphorylation and the Lysosome-Associated Membrane Protein 1 (LAMP-1), respectively. The size and morphology of the cells were also measured. The intracellular Ca2+ flux of NT and CAR-T cells upon engagement with the antigen-presenting cell surface was reported. Results suggest that NT and CD19.CART cells have comparable activation levels, while NT have higher degranulation levels than CD19.CAR-T cells and GD2.CAR-T cells. The findings show that antigen-presenting cell surfaces allow a quantitative analysis of the molecules involved in synapse formation in different CAR-T cells in a systematic, reproducible manner.
Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy
Creators: name: Wen, D.
name: Li, H.
name: Gu, Z.
name: Wang, Z.
name: Dotti, G.
name: Zeng, Y.
name: Chen, G.
name: Wirz, R.E.
name: Chen, Z.
Publisher: name: National Academy of Sciences
Year: 2020

description: Despite the promise of immune checkpoint blockade (ICB) therapy against cancer, challenges associated with low objective response rates and severe systemic side effects still remain and limit its clinical applications. Here, we described a cold atmospheric plasma (CAP)mediated ICB therapy integrated with microneedles (MN) for the transdermal delivery of ICB. We found that a hollow-structured MN (hMN) patch facilitates the transportation of CAP through the skin, causing tumor cell death. The release of tumor-associated antigens then promotes the maturation of dendritic cells in the tumor-draining lymph nodes, subsequently initiating T cell-mediated immune response. Anti-programmed death-ligand 1 antibody (aPDL1), an immune checkpoint inhibitor, released from the MN patch further augments the antitumor immunity. Our findings indicate that the proposed transdermal combined CAP and ICB therapy can inhibit the tumor growth of both primary tumors and distant tumors, prolonging the survival of tumor-bearing mice.
(4145) Ellen Musgreave Bashforth
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bounds on the number of non-simple closed geodesics on a surface
Creators: name: Sapir, Jenya
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We give bounds on the number of non-simple closed curves on a negatively curved surface, given upper bounds on both length and self-intersection number. In particular, it was previously known that the number of all closed curves of length at most $L$ grows exponentially in $L$. We get exponentially tighter bounds given weak conditions on self-intersection number.
I commissari politici come educatori della guerra partigiana
Creators: name: Calvetto, Silvano
Publisher: name: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici
Year: 2025
Subjects: Politica; Educazione; Guerra partigiana; Democrazia; Politics; Education; Partisan Warfare; Democracy

description: La guerra partigiana rappresenta un momento di rottura nella storia del paese. Accanto alle ragioni politiche e militari vanno considerate quelle di tipo educativo, come conferma la presenza dei commissari politici nei gruppi combattenti. Il loro compito, infatti, è quello di occuparsi della formazione dei partigiani, non solamente intesa come indottrinamento ideologico, ma come acquisizione di una mentalità nuova, di tipo democratico, dopo l’esperienza del fascismo.

The partisan war represents a moment of rupture in the history of Italy. Beyond the political and military reasons, those of an educational nature must be considered, as confirmed by the presence of political commissars in the fighting groups. Their task, in fact, is to deal with the education of the partisans, not only understood as ideological indoctrination, but as the acquisition of a new democratic mentality after the experience of fascism.
description: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici, V. 4, N. 2 (2024)
Connectedness of cup products for polynomial representations of $GL_n$ and applications
Creators: name: Touzé, Antoine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20G10

description: We find conditions such that cup products induce isomorphisms in low degrees for extensions between stable polynomial representations of the general linear group. We apply this result to prove generalizations and variants of the Steinberg tensor product theorem. Our connectedness bounds for cup product maps depend on numerical invariants which seem also relevant to other problems, for example to study the cohomological behavior of the Schur functor.
description: 3rd version. Several references added. A few typos corrected. 'K\"unneth condition' added in theorem 3.6, and proof rewritten hopefully in a nicer way. Section 4 reorganized - for easier reading one part of the former section is now appendix B
Delegating Management, Augmenting the Mind: What could be the role for technology in commoning practices?
Creators: name: Savic, Selena
Publisher: name: University of Nicosia Research Foundation
Year: 2020
Subjects: commoning
design
technological imaginary
decentralization
agent-based modelling
communication systems
decision-making

description: In 1974, French feminist writer Françoise D' Eaubonne identified two threats to humanity: the destruction of the environment and overpopulation (d’Eaubonne, 1974). “Feminism or death”, she proclaimed alarmingly. The oil crisis of the 1970s heightened the awareness of the finiteness of resources (even though their scarcity was artificially generated in this particular case) and fuelled a plethora of thoughts about alternatives to the capitalist economic system that was perceived as consumptive of the very energy and human resources it attempted to manage. Even though such counterculture ideas did not gain mainstream recognition, and precisely because they failed to cause deeper changes to the system, similar claims are being made today. The Global Footprint Network estimates that the pace of using resources is alarmingly faster than their regeneration capacity1: in eight months we use twelve months worth of resources. Climate change activists as young as teenagers address political and business leaders at World Economic Forums2. Commons-based economy and commoning are proposed by many as more stable, resilient forms of governance (Bollier & Helfrich, 2015; Gibson-Graham, Cameron, & Healy, 2013). It is not a surprise that Elinor Ostrom was given Nobel Prize in Economics for her work on the on governing the commons (Ostrom, 1990) right after the biggest financial crisis we experience in recent times (2008). This discourse is often characterized by inflammatory statements. With the current text, I propose to think calmly about burning topics such as resource sharing, collective decision making and the role of technology in these processes. The relationship between commoning and technology is explored here in the scope of the research project Thinking Toys for Commoning3, looking into the ways media-based tools – such as computer-based models – can make complex commoning processes not only visible but also comprehensible. A multidisciplinary team gathers around questions raised by both lived experience of commoning in a community of individuals, and the experimental approach to computer modelling. We explore, expose and make explicit different phenomena related to common living. We collaborate with three Swiss housing cooperatives, probing organizational and communication challenges they face.
Cryo-shocked cancer cells for targeted drug delivery and vaccination
Creators: name: Wang, J.
name: Abdou, P.
name: Dotti, G.
name: Wang, Z.
name: Tu, Y.
name: Gu, Z.
name: Ci, T.
name: Li, H.
name: Chen, G.
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: Live cells have been vastly engineered into drug delivery vehicles to leverage their targeting capability and cargo release behavior. Here, we describe a simple method to obtain therapeutics-containing “dead cells” by shocking live cancer cells in liquid nitrogen to eliminate pathogenicity while preserving their major structure and chemo-taxis toward the lesion site. In an acute myeloid leukemia (AML) mouse model, we demonstrated that the liquid nitrogen–treated AML cells (LNT cells) can augment targeted delivery of doxorubicin (DOX) toward the bone marrow. Moreover, LNT cells serve as a cancer vaccine and promote antitumor immune responses that prolong the survival of tumor-bearing mice. Preimmunization with LNT cells along with an adjuvant also protected healthy mice from AML cell challenge.
Self-Diffusiophoretic Colloidal Propulsion Near a Solid Boundary
Creators: name: Mozaffari, Ali
name: Sharifi-Mood, Nima
name: Koplik, Joel
name: Maldarelli, Charles
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study the diffusiophoretic self-propulsion of a colloidal catalytic particle due to a surface chemical reaction in a vicinity of a solid wall. Diffusiophoresis is a chemico-mechanical transduction mechanism in which a concentration gradient of an interacting solute produces an unbalanced force on a colloidal particle and drives it along the gradient. We consider a spherical particle with an axisymmetric reacting cap covering the polar angle range $0\le θ\le θ_{cap}$ in the presence of a repulsive solute, near an infinite planar wall, and solve the coupled solute concentration and Stokes equations, using a mixture of numerical and analytic arguments. The resulting particle trajectory is determined by $θ_{cap}$ and the initial orientation of the symmetry axis with respect to the plane. At normal incidence the particle initially moves away from or towards the wall, depending on whether the cap faces towards or away, respectively, but even in the latter case the particle never reaches the wall due to hydrodynamic lubrication resistance. For other initial orientations, when $θ_{cap}\le 115^{\circ}$ the particle either moves away immediately or else rotates along its trajectory so as to cause the active side to face the wall and the particle to rebound. For higher coverage we find trajectories where the particle skims along the wall at constant separation or else comes to rest. We provide a phase diagram giving the nature of the trajectory (repulsion, rebound, skimming or stationary) as a function of $θ_{cap}$ and the initial orientation.
Artibeus schwartzi
Creators: name: Wilson, Don E.
name: Mittermeier, Russell A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Phyllostomidae
Artibeus
Artibeus schwartzi

description: 195. Schwartz’s Fruit-eating Bat Artibeus schwartzi French: Artibée de Schwartz / German: Schwartz-Fruchtvampir / Spanish: Artibeo de Schwartz Taxonomy. Artibeus jamaicensis schwartz J. K. Jones, 1978, “ Mesopotamia, 350 fi. [= 107 m], Charlotte Parish, St. Vincent (Lesser Antilles).” Artibeus schwartzi is in subgenus Artibeus. It was long considered a subspecies, but its distinction was validated through phylogenetic analyses. Later,its possible hybrid origin was proposed, with nuclear genome resulting from admixture of genomes of extant species A. jamaicensis and A. planirostris. Monotypic. Distribution. Known only from the Lesser Antilles, including St. Kitts, Nevis, Montserrat, St. Lucia, St. Vincent, the Grenadines (Union and Carriacou), and Grenada Is. Descriptive notes. Head—body 85-96 mm (tailless), ear 19-24 mm, hindfoot 18-22 mm, forearm 60-67 mm; weight 42-46 g. Schwartz’s Fruit-eating Batis large, with dorsal fur varying from dark brownish to grayish brown and hairs over shoulders paler. Furis short and dense. Facial stripes are grayish white and indistinct. Venter is dark brownish, washed with gray. Hairs have pale bases, dark subterminal band, and whitish or gray tips. Wings are brownish, paler at tips. Uropatagium is broad, with marked V-shaped groove, wide margin, and sparse hair. Dental formulas 12/2, C1/1,P 2/2, M 3/3 (x2) = 32. Skull is large and massive, lacking distinct supraorbital shield typical of the Great Fruit-eating Bat (A. lLituratus). M? is usually absent (only present in 12:9% of known specimens). Habitat. Humid forests and mangroves but now mostly transformed landscapes with farmlands, fruit (banana) groves, and residential areas from sea level to elevations of c. 120 m. Schwartz’s Fruit-eating Bats is usually recorded near streams, wet areas, and fruit groves. Food and Feeding. Schwartz's Fruit-eating Bat is primarily frugivorous. Breeding. One juvenile and two subadult (non-reproductive) Schwartz’s Fruit-eating Bats were recorded at late August. Activity patterns. Schwartz's Fruit-eating Bats are thought to roosts in caves and trees. Movements, Home range and Social organization. Schwartz's Fruit-eating Bats are gregarious. Status and Conservation. Classified as Data Deficient on The IUCN Red List. Information on population status and distribution of Schwartz’s Fruit-eating Bat are lacking. Bibliography. Jones (1978), Larsen, Hoofer et al. (2007), Larsen, Marchan-Rivadeneira & Baker (2010a), Pedersen et al. (2013), Pumo et al. (1996).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Phyllostomidae, pp. 444-583 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on pages 574-575, DOI: 10.5281/zenodo.6458594
Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells
Creators: name: Dotti, G.
name: Gu, Z.
name: Wang, C.
name: Hu, Q.
name: Ahn, S.
name: Chen, G.
name: Ligler, F.S.
name: Ogunnaike, E.A.
name: Dukhovlinova, E.
name: Chen, Q.
Publisher: name: Wiley-VCH Verlag
Year: 2019

description: Chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR T cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and the immunosuppressive tumor microenvironment usually account for the reduced efficacy of CAR T cells in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure, increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. Therefore, the combination of mild hyperthermia with the adoptive transfer of CAR T cells can potentially increase the therapeutic index of these cells in solid tumors. It is found that the chondroitin sulfate proteoglycan-4 (CSPG4)-specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. The findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR T cells within solid tumors.
Microlensing Constraints on Broad Absorption and Emission Line Flows in the Quasar H1413+117
Creators: name: O'Dowd, Matthew J.
name: Bate, Nicholas F.
name: Webster, Rachel L.
name: Labrie, Kathleen
name: Rogers, Joshua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present new integral field spectroscopy of the gravitationally lensed broad absorption line (BAL) quasar H1413+117, covering the ultraviolet to visible rest-frame spectral range. We observe strong microlensing signatures in lensed image D, and we use this microlensing to simultaneously constrain both the broad emission and broad absorption line gas. By modeling the lens system over the range of probable lensing galaxy redshifts and using on a new argument based on the wavelength-independence of the broad line lensing magnifications, we determine that there is no significant broad line emission from smaller than ~20 light days. We also perform spectral decomposition to derive the intrinsic broad emission line (BEL) and continuum spectrum, subject to BAL absorption. We also reconstruct the intrinsic BAL absorption profile, whose features allow us to constrain outflow kinematics in the context of a disk-wind model. We find a very sharp, blueshifted onset of absorption of 1,500 km/s in both C IV and N V that may correspond to an inner edge of a disk-wind's radial outflow. The lower ionization Si IV and Al III have higher-velocity absorption onsets, consistent with a decreasing ionization parameter with radius in an accelerating outflow. There is evidence of strong absorption in the BEL component which indicates a high covering factor for absorption over two orders of magnitude in outflow radius.
description: 29 pages, 8 figures
Fractional kinetics emerging from ergodicity breaking in random media
Creators: name: Molina-García, Daniel
name: Pham, Tuan Minh
name: Paradisi, Paolo
name: Manzo, Carlo
name: Pagnini, Gianni
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences
subject: 60G22, 60J60, 26A33

description: We present a modelling approach for diffusion in a complex medium characterized by a random length scale. The resulting stochastic process shows subdiffusion with a behavior in qualitative agreement with single particle tracking experiments in living cells, such as ergodicity breaking, p-variation and aging. In particular, this approach recapitulates characteristic features previously described in part by the fractional Brownian motion and in part by the continuous-time random walk. Moreover, for a proper distribution of the length scale, a single parameter controls the ergodic-to-nonergodic transition and, remarkably, also drives the transition of the diffusion equation of the process from non-fractional to fractional, thus demonstrating that fractional kinetics emerges from ergodicity breaking.
description: Extended version of arXiv:1508.01361: Gianni Pagnini, Daniel Molina-Garc\'ia, Tuan Minh Pham, Carlo Manzo, Paolo Paradisi, Ergodicity breaking in random media and the foundation of fractional kinetics
(4146) John Bashforth
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells
Creators: name: Liu, R.
name: Sun, C.
name: Kren, N.P.
name: Ma, X.
name: Chen, Y.
name: Dotti, G.
name: Herrera, S.G.
name: Hirabayashi, K.
name: Montgomery, S.A.
name: Savoldo, B.
name: Du, H.
name: Yeh, J.J.
name: Pylayeva-Gupta, Y.
name: Greene, K.
name: Michaud, D.
name: Wang, X.
name: Tiruthani, K.
name: Ahn, S.
name: Ferrone, S.
name: Mirlekar, B.
name: Ferrone, C.R.
name: Xu, Y.
Publisher: name: Cell Press
Year: 2019

description: The high expression across multiple tumor types and restricted expression in normal tissues make B7-H3 an attractive target for immunotherapy. We generated chimeric antigen receptor (CAR) T cells targeting B7-H3 (B7-H3.CAR-Ts) and found that B7-H3.CAR-Ts controlled the growth of pancreatic ductal adenocarcinoma, ovarian cancer and neuroblastoma in vitro and in orthotopic and metastatic xenograft mouse models, which included patient-derived xenograft. We also found that 4-1BB co-stimulation promotes lower PD-1 expression in B7-H3.CAR-Ts, and superior antitumor activity when targeting tumor cells that constitutively expressed PD-L1. We took advantage of the cross-reactivity of the B7-H3.CAR with murine B7-H3, and found that B7-H3.CAR-Ts significantly controlled tumor growth in a syngeneic tumor model without evident toxicity. These findings support the clinical development of B7-H3.CAR-Ts.
The king oyster mushroom Pleurotus eryngii behaves as a necrotrophic pathogen of Eryngium campestre
Creators: name: Carlavilla, Juan Ramon
name: Manjón, José Luis
Publisher: name: Italian Journal of Mycology
Year: 2023

description: Under natural conditions in Spain, the fruiting bodies of Pleurotus eryngii var. eryngii, a basidomycete of great economic and gastronomic importance, appears at the base of the stem of (mainly) Eryngium campestre, surrounded by the plant’s dried-out basal leaves. Traditionally collected in the wild of Mediterranean areas, this fungus is now cultivated all over the world for its culinary and even medicinal properties. However, controversy exists regarding its lifestyle. Some authors indicate it is a saprotroph, while others suggest it is a weak or even virulent parasite that causes male sterility in E. campestre. The present work aims to clarify whether P. eryngii behaves as a saprotroph, a weak or virulent parasite to E. campestre. The soil beside the roots of naturally growing E. campestre plants was inoculated with a commercial strain of P. eryngii, and the trophic mode of the fungus recorded. Soil and root samples were subjected to molecular analysis to confirm the absence/presence of the fungus. The death of the plants and the molecular analysis showed P. eryngii is a facultative necrotrophic parasite of E. campestre in natural conditions and a virulent parasite in greenhouse.
description: Italian Journal of Mycology, Vol. 52 (2023)
A Thesis Submitted to the School of Graduate Studies of Addis Ababa Institute of Technology, in Partial Fulfillment of the Requirements for the Degree of Master of Science in Chemical Engineering (Food Engineering Stream)
Creators: name: Abayneh Taye
Publisher: name: Zenodo
Year: 2013

description: The study was conducted with the aim of producing protein enriched extruded product that can be used as a protein supplement by combining legumes, cereal and oil seeds. Accordingly, maize, defatted soy flour and chickpea were selected based on their nutritional value, availability in the local market and affordability. By Applying mixture experimental design, formulation containing 589 g/kg corn, 291 g/kg defatted soy flour, and 120 g/kg of chickpea flour was selected as the best source of protein. The effects of extrusion parameters on the specific length, bulk density, and expansion ratio, functional properties (water solubility index, water absorption index and water holding capacity) were done, after extruding the blend with moisture content (17and 20%) barrel temperature (120, 130, and 140 0C), and screw speed (150,200 and 250 rpm). Sensory characteristics of extruded products (texture, color and overall acceptability) were also studied to evaluate the suitability of the product as extruded snack. Using the blend ratio obtained from the design, an extrudate containing 21.34% protein, 2.81 % of fat and 65.06% of carbohydrate was found to be the protein enriched product.
Cancer immunotherapy with T cells carrying bispecific receptors that mimic antibodies
Creators: name: Dotti, G.
name: Li, J.
name: Savoldo, B.
name: Gao, K.
name: Sun, C.
name: Hirabayashi, K.
name: Ahn, S.
name: Liu, R.
name: Li, H.
Publisher: name: American Association for Cancer Research Inc.
Year: 2019

description: Tumors are inherently heterogeneous in antigen expression, and escape from immune surveillance due to antigen loss remains one of the limitations of targeted immunotherapy. Despite the clinical use of adoptive therapy with chimeric antigen receptor (CAR)–redirected T cells in lymphoblastic leukemia, treatment failure due to epitope loss occurs. Targeting multiple tumor-associated antigens (TAAs) may thus improve the outcome of CAR-T cell therapies. CARs developed to simultaneously target multiple targets are limited by the large size of each single-chain variable fragment and compromised protein folding when several single chains are linearly assembled. Here, we describe single-domain antibody mimics that function within CAR parameters but form a very compact structure. We show that antibody mimics targeting EGFR and HER2 of the ErbB receptor tyrosine kinase family can be assembled into receptor molecules, which we call antibody mimic receptors (amR). These amR can redirect T cells to recognize two different epitopes of the same antigen or two different TAAs in vitro and in vivo
title: Яндекс.Дзен: новый медийный и обучающий формат
Creators: name: Каминская, Татьяна
name: Томмингас, Томас
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: Авторы статьи, являясь одновременно журналистами и преподавателями, предлагают осмысление результатов своей работы на новой платформе Яндекс.Дзен как площадке для продвижения медиа, так и инструмента для профессионального медиаобразования. Рассматривая обучение журналистов и PR-специалистов как практико-ориентированное, авторы связали его с процессом реализации медиапроекта полного цикла каждым студентом: от создания собственного канала до его монетизации. Медийная составляющая платформы рассмотрена на примере успешной монетизации (с начала 2018 года) сетевого издания «53 новости», а обучающая — в рамках подготовки журналистов и специалистов по рекламе и PR в вузе (Новгородский государственный университет им. Ярослава Мудрого: дисциплины «Основы теории СМИ» и «Медиапроекты и их продвижение в интернете»). В статье показано, почему платформа «Яндекс.Дзен» может служить подходящим инструментом как для продвижения региональных новостных изданий, так и не менее конкурентоспособным для подготовки специалистов по сравнению с группами и персональными аккаунтами в социальных медиа.