cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization
Creators: name: Dai, Shipeng
name: Xu, Fan
name: Xu, Xiaozhang
name: Huang, Tian
name: Wang, Yiming
name: Wang, Hongyu
name: Xie, Yucheng
name: Yue, Lei
name: Zhao, Wenhu
name: Xia, Yongxiang
name: Gu, Jian
name: Qian, Xiaofeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 2
Vom Saasberg gegen Fronalpstock bis Magereu
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Federzeichnung. Auf blauem Papier
Format: 136:148 mm
Zusätzlich vermerkt ist:
Glarus Nr. 107 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
title: Überlegungen zur Verknüpfung von Daten der Integrierten Erwerbsbiographien (IEB) und der Verdienststrukturerhebung (VSE)
Creators: name: Himmelreicher, Ralf
name: Vom Berge, Philipp
name: Fitzenberger, Bernd
name: Günther, Roland
name: Müller, Dana
Publisher: name: German Data Forum ( RatSWD)
Year: 2017

description: RatSWD Working Paper Series
Gravasalvas Gruppe von der SE-Seite des Silsersees
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Federzeichnung, mit geologischem Kolorit
Format: 235:620 mm
Zusätzlich vermerkt ist:
Tab. II, Fig. 1
description: ETH-Bibliothek
Pedon war bont ar naoned
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
title: Ist Berufsbildung ein Mittel zur Minderung von Migrationsdruck? Zum Verhältnis zwischen Migration, Berufsbildung und Entwicklung
Creators: name: Langthaler, Margarita
name: Gündüz, Dilara
Publisher: name: Austrian Foundation for Development Research
publisherIdentifier: https://ror.org/054z0bn29
publisherIdentifierScheme: ROR
Year: 2020

description: Migration ist auch in der Entwicklungszusammenarbeit zu einem Schwerpunktthema geworden. In den Strategien zur Minderung von Migrationsdruck spielen Bildung und Berufsbildung eine wesentliche Rolle. Berufsbildung soll dabei helfen, die Ursachen von Migration zu bekämpfen, indem sie den Menschen in Entwicklungsländern Lebensperspektiven eröffnet. Doch wie evidenzbasiert sind diese Strategien? Was sagt die Forschung zum Zusammenhang zwischen (Berufs)Bildung und Migration? Dazu fand im Jänner 2020 eine Konferenz in Wien statt. Die vorliegende Policy Note fasst deren Ergebnisse zusammen.
Additional file 2 of Analytical and clinical performance evaluation of a new NT-proBNP assay
Creators: name: Feng, Pingfeng
name: Qin, Junlong
name: Chai, Zhixin
name: Zhang, Yajie
name: Zhao, Minghai
name: Liu, Liya
name: Zhang, Lijun
name: Chen, Yaqiong
name: Xiong, Yufeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Supplementary Material 2: Supplementary Fig. 1. Linearity of NT-proBNP in Low concentration interval.
Skizze S vom Klein Aubrig gegen Köpfenstock, Gross Aubrig (Vorderseite). Goris, Diethelm (Rückseite)
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung
Format: 216:83 mm
Zusätzlich vermerkt ist:
Schwyz Nr. 217 a - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Vom Fostöckli gegen Ringelspitzen, Ofen, Richetli
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung, mit geologischem Kolorit
Format: 145:630 mm
Zusätzlich vermerkt ist:
Glarus Nr. 184 - nicht entschlüsselter Verweis oder Zusatz
XI S. 785 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Hohmättli. Skizze von seinem NE-Fuss
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung, mit geologischer Bemerkung
Format: 135:257 mm
Zusätzlich vermerkt ist:
St. Gallen Nr. 301 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
РОЛЬ ФОЛЬКЛОРА В ВОСПИТАНИИ И ОБРАЗОВАНИИ МОЛОДЁЖИ: ТРАДИЦИИ И СОВРЕМЕННЫЕ РЕАЛИИ
Creators: name: Пардабоева, Дилфуза
Publisher: name: Zenodo
Year: 2025

description: Фольклор, являясь важнейшей частью культурного наследия народов, представляет собой уникальное средство воспитания и образования. В статье рассматривается значение народного творчества в формировании мировоззрения молодёжи, его роль в сохранении культурных традиций и передаче ценностей через поколения. Особое внимание уделено анализу использования фольклора в современных образовательных подходах и методах работы с молодёжью.
The Installation Design of Solar Panels for Village Houses HK with Optimization-based Efficiency for Sustainable Environmental
Creators: name: AIRCC
Publisher: name: Zenodo
Year: 2025

description: The primary objective of this project is to provide a meaningful contribution towards the sustainable development of rural communities via the facilitation of solar panel installations on residential houses in Sai Kung Village, located in Hong Kong. Additionally, the project aims to build a comprehensive framework for the sale of excess power generated from these solar panels to CLP. The suggested system aims to fulfill the electrical requirements of the designated household, so making a valuable contribution towards the sustainable and economic development. This installation design using optimization of the energy and financial efficiency with sustainable environmental protections.
Markus Tauschek (Hrsg.): Macht, Politische Kultur, Widerstand. Studentischer Protest an der Universität Kiel, Münster / New York: Waxmann 2016, 198 pp., hardcover 24.90 €, ISBN 978-3-8309-3388-5.
Creators: name: Sepp, Benedikt
Publisher: name: Moving the Social
Year: 2018

description: This is a review of Markus Tauschek (Hrsg.): Macht, Politische Kultur, Widerstand. Studentischer Protest an der Universität Kiel, Münster / New York: Waxmann 2016, 198 pp., hardcover 24.90 €, ISBN 978-3-8309-3388-5.
description: Moving the Social, Vol 60 (2018): Social Movements, Protest, and Academic Knowledge Formation. Interactions since the 1960s
Vorderglärnisch von Riedern aus
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Federzeichnung, mit Schichtensignatur
Format: 115:118 mm
Zusätzlich vermerkt ist:
Glarus Nr. 256 a - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Svea Koischwitz: Der Bund Freiheit der Wissenschaft in den Jahren 1970 – 1976: Ein Interessenverband zwischen Studentenbewegung und Hochschulreform, Wien / Köln / Weimar: Böhlau Verlag 2017, 541 pp., € 70.00 [D] / € 72.00 [A], ISBN 978-3-412-50554-7.
Creators: name: Keim, Michaela
Publisher: name: Moving the Social
Year: 2018

description: This is a review of Svea Koischwitz: Der Bund Freiheit der Wissenschaft in den Jahren 1970 – 1976: Ein Interessenverband zwischen Studentenbewegung und Hochschulreform, Wien / Köln / Weimar: Böhlau Verlag 2017, 541 pp., € 70.00 [D] / € 72.00 [A], ISBN 978-3-412-50554-7.
description: Moving the Social, Vol 60 (2018): Social Movements, Protest, and Academic Knowledge Formation. Interactions since the 1960s
Zwischen dem Räderten und Ochsenstock gegen Twirrenkette
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1835

description: Federzeichnung
Format: 123:195 mm
Zusätzlich vermerkt ist:
Glarus Nr. 326 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Landschaft ob Bergün mit Passweg u. Steg. Aquarell von Hans Konrad Escher von der Linth
Creators: name: Escher, Hans Conrad (von der Linth)
Publisher: name: [s.n.]
Year: 1806

description: Federzeichnung, aquarelliert
Format: 215:235 mm
Zusätzlich vermerkt ist:
Bünden Nr. 396 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Von der Aberli Hütte gegen Klein Muttstein
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung
Format: 208:130 mm
Zusätzlich vermerkt ist:
Schwyz Nr. 208 a - nicht entschlüsselter Verweis oder Zusatz
I 244, 25 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Additional file 2 of Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients
Creators: name: Hovorkova, Lenka
name: Winkowska, Lucie
name: Skorepova, Justina
name: Krumbholz, Manuela
name: Benesova, Adela
name: Polivkova, Vaclava
name: Alten, Julia
name: Bardini, Michela
name: Meyer, Claus
name: Kim, Rathana
name: Trahair, Toby N.
name: Clappier, Emmanuelle
name: Chiaretti, Sabina
name: Henderson, Michelle
name: Sutton, Rosemary
name: Sramkova, Lucie
name: Stary, Jan
name: Polakova, Katerina Machova
name: Marschalek, Rolf
name: Metzler, Markus
name: Cazzaniga, Giovanni
name: Cario, Gunnar
name: Trka, Jan
name: Zaliova, Marketa
name: Zuna, Jan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: Virology

description: Supplementary Material 2
title: Erneuerbare Energien in Deutschland 2019
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Erneuerbare Energie
subject: Regenerative Energie
subject: Windenergie
subject: Photovoltaik
subject: AGEE-Stat
subject: Arbeitsgruppe Erneuerbare Energien-Statistik
subject: Klima | Energie

description: Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat) bilanziert im Auftrag des Bundesministeriums für Wirtschaft und Energie regelmäßig die Nutzung der erneuerbaren Energien in Deutschland. Jährlich erstellt die AGEE-Stat in diesem Rahmen eine erste amtliche Abschätzung zur Entwicklung der erneuerbaren Energien im jeweiligen Vorjahr und veröffentlicht die Erkenntnisse im Hintergrundpapier „Erneuerbare Energien in Deutschland“.Die nun vorliegende Publikation beschreibt die aktuellen Entwicklungen in den Bereichen Strom, Wärme und Verkehr, ergänzt um Zahlen zu den wirtschaftlichen Effekten und der Emissionsvermeidung durch erneuerbare Energien. Die Ergebnisse sind graphisch aufbereitet und stehen im Anhang vollständig als Datensatz zur Verfügung.
Dracontogena schnirchi Karisch 2005
Creators: name: Aarvik, Leif
name: Karisch, Timm
name: Marthinsen, Gunnhild
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Tortricidae
Dracontogena
Dracontogena schnirchi

description: Dracontogena schnirchi Karisch, 2005
(Figs. 74, 75)
Dracontogena schnirchi Karisch 2005: 464, text fig. 17, pl. 1, fig. 11.
Type material. Holotype, Ƥ, ZAIRE: Prov. Equateur, Kalamba 55 km südl. Mbandaka, 3 km östlich Ort, 8.viii.1991, T. Karisch, genitalia slide T. Karisch 1676 (MNVD).
Diagnosis. Wingspan 24.5 mm. The forewing is blackish brown; the dorsal maculae are broadly interconnected, with dark dots and streaks. The female genitalia has a quadrate sterigma with rounded corners, with the posterior edge strongly sclerotised; and the sclerites posterior of the sterigma are united, forming a broad plate.
Remarks. Known only from the holotype. The broadly interconnected dorsal maculae with tiny marks are characteristic. Without knowledge of the male, the position of D. schnirchi within the genus cannot be determined.
description: Published as part of Aarvik, Leif, Karisch, Timm & Marthinsen, Gunnhild, 2012, Review of the Afrotropical genus Dracontogena Diakonoff, 1970 (Lepidoptera, Tortricidae) with descriptions of eight new species, pp. 345-372 in Zootaxa 3478 on page 365, DOI: 10.11646/zootaxa.3478.1.32, http://zenodo.org/record/282268
Am Abhang der Siwillen (Diestal) gegen Ortstock, Glärnisch
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1864

description: Federzeichnung über Bleistift, mit Schichtensignatur
Format: 128:418 mm
Zusätzlich vermerkt ist:
Glarus Nr. 123 b - nicht entschlüsselter Verweis oder Zusatz
XI S. 423 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Skizze S der Kapelle von Gross beim Wasserkanälchen gegen Amsleten
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung
Format: 222:81 mm
Zusätzlich vermerkt ist:
Schwyz Nr. 138 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Skizze auf dem Eisenoolith
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung, teilweise mit geologischem Kolorit und Geländesignatur
Format: 176:225 mm
Zusätzlich vermerkt ist:
Bünden Nr. 75 i - nicht entschlüsselter Verweis oder Zusatz
XI S. 695 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Additional file 1 of The effect of transcranial magnetic stimulation on cognitive function in post-stroke patients: a systematic review and meta-analysis
Creators: name: Zhu, Mingjin
name: Huang, Siyu
name: Chen, Wenjun
name: Pan, Guoyuan
name: Zhou, Yibo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Mental Health

description: Supplementary Material 1
Understanding farmers’ intention to perform result-based agri-environmental schemes for the improved provision of biodiversity and soil quality
Creators: name: Eichhorn, Theresa
name: Kantelhardt, Jochen
name: Schaller, Lena Luise
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This article investigates the influence of socio-psychological factors on farmers’ intention to perform result-based agri-environmental schemes for the improved provision of biodiversity and soil quality. We present a Structural Equation Model, which uses an extended Technology Acceptance Model as a theoretical basis for better understanding farmers’ decision-making. Results from a survey of 235 Austrian farmers show that behavioural factors such as self-efficacy, perceived risk, and subjective norm directly or indirectly impact farmers’ intention to perform result-based schemes. Findings stress the importance of farmers’ surrounding networks for the successful implementation of such schemes and the need for including mechanisms into their design, which are suited to diversify risk and increase self-efficacy. In conclusion, our results emphasize that considering the influence of socio-psychological factors on farmers’ decision-making may offer new levers in the design of more environmentally effective and efficient agri-environmental-climate measures.
Gamperdun. Skizze zwischen Oberriseten und Bützi
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistiftzeichnung, mit Schichtensignatur
Format: 108:172 mm
Zusätzlich vermerkt ist:
Glarus Nr. 200 a - nicht entschlüsselter Verweis oder Zusatz
XI S. 783 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Probing the structural stability of R-phycocyanin under pressure
Creators: name: Minic, Simeon
name: Velickovic, Luka
name: Annighöfer, Burkhard
name: Thureau, Aurélien
name: Gligorijevic, Nikola
name: Jovanovic, Zorana
name: Brûlet, Annie
name: Combet, Sophie
Publisher: name: arXiv
Year: 2024
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: The red macroalgae Porphyra, commonly known as Nori, is widely used as food around the world due to its high nutrient content, including the significant abundance of coloured phycobiliproteins (PBPs). Among these, R-phycocyanin (R-PC) stands out for its vibrant purple colour and numerous bioactive properties, making it a valuable protein for the food industry. However, R-PC's limited thermal stability necessitates alternative processing methods to preserve its colour and bioactive properties. Our study aimed to investigate the in-situ stability of oligomeric R-PC under high pressure (HP) conditions (up to 4,000 bar) using a combination of absorption, fluorescence, and small-angle X-ray scattering (SAXS) techniques. The unfolding of R-PC is a multiphase process. Initially, low pressure induces conformational changes in the R-PC oligomeric form (trimers). As pressure increases above 1,600 bar, these trimers dissociate into monomers, and at pressures above 3,000 bar, the subunits begin to unfold. When returned to atmospheric pressure, R-PC partially refolds, retaining 50% of its original colour absorbance. In contrast, heat treatment causes irreversible and detrimental effects on R-PC colour, highlighting the advantages of HP treatment in preserving both the colour and bioactive properties of R-PC compared to heat treatment. SIGNIFICANCE: HP is a powerful probe that reveals intermediate states of proteins through subtle structural changes not accessible by other denaturation methods. By combining HP-small-angle-Xray scattering with HP-absorption and fluorescence spectroscopy, we elucidate the multiphase unfolding process of R-phycocyanin. This process includes: 1) conformational changes, 2) oligomer dissociation at moderate pressures, and 3) monomer unfolding. Our approach provides new opportunities for the structural determination of protein intermediates and oligomers using HP.
Von der Miesegg gegen Rigi
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1846

description: Federzeichnung, grau laviert
Format: 113:193 mm
Zusätzlich vermerkt ist:
Schwyz Nr. 217 a - nicht entschlüsselter Verweis oder Zusatz
II S. 81 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Aus dem Hintergrunde von Val d'Agnici
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1837

description: Federzeichnung über Bleistift
Format: 85:175 mm
Zusätzlich vermerkt ist:
Bünden Nr. 287 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Dracontogena lucki Karisch 2005
Creators: name: Aarvik, Leif
name: Karisch, Timm
name: Marthinsen, Gunnhild
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Tortricidae
Dracontogena
Dracontogena lucki

description: Dracontogena lucki Karisch, 2005
(Figs. 76, 77)
Dracontogena lucki Karisch 2005: 463, text fig. 16, pl. 1, fig. 6.
Type material. Holotype, Ƥ, KENYA: Mugaga, vi.1968, E.S Brown, genitalia slide BMNH 30598 (BMNH).
Diagnosis. Wingspan 28.0 mm. The forewing has the typical Dracontogena pattern, blackish brown with two white, triangular marks on the dorsum. The female genitalia resemble those of D. kingstoni n. sp. with a large oval sterigma, but differ from the latter by the lack of a broad sclerotised lateral edge of sterigma and paired sclerites posterior of the sterigma.
Remarks. Known only from the holotype. Judging from the genitalia, it appears to be closely related with D. kingstoni n. sp.
description: Published as part of Aarvik, Leif, Karisch, Timm & Marthinsen, Gunnhild, 2012, Review of the Afrotropical genus Dracontogena Diakonoff, 1970 (Lepidoptera, Tortricidae) with descriptions of eight new species, pp. 345-372 in Zootaxa 3478 on page 368, DOI: 10.11646/zootaxa.3478.1.32, http://zenodo.org/record/282268
MEASURED project dissemination activities 1
Creators: name: PNO
Publisher: name: Zenodo
Year: 2025

description: Deliverable D7.9 focuses on the dissemination activities planned for the MEASURED project, which will be carried out in the upcoming months of implementation. This document highlights the initiatives already planned by the consortium for publicly disclosing the results achieved within MEASURED.
description: Deliverable D7.9 focuses on the dissemination activities planned for the MEASURED project, which will be carried out in the upcoming months of implementation. This document highlights the initiatives already planned by the consortium for publicly disclosing the results achieved within MEASURED.
Im Walenstädterberg gegen Kuhmettlen
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1857

description: Federzeichnung, mit Schichtensignatur und geologischer Bemerkung. Auf blauem Papier
Format: 134:217 mm
Zusätzlich vermerkt ist:
St. Gallen Nr. 159 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Additional file 1 of Primary health care utilisation and delivery in remote Australian clinics during the COVID-19 pandemic
Creators: name: Mathew, Supriya
name: Fitts, Michelle S.
name: Liddle, Zania
name: Bourke, Lisa
name: Campbell, Narelle
name: Murakami-Gold, Lorna
name: Russell, Deborah J
name: Humphreys, John S.
name: Rossingh, Bronwyn
name: Zhao, Yuejen
name: Jones, Michael P.
name: Boffa, John
name: Ramjan, Mark
name: Tangey, Annie
name: Schultz, Rosalie
name: Mulholland, Edward
name: Wakerman, John
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Tetramorium forte Forel
Creators: name: Güsten, R.
name: Schulz, A.
name: Sanetra, M.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium forte

description: The name we stabilize here for this taxon, Tetramorium forte Forel, 1904, has occasionally been applied to other taxonomic species, including eastern European ones (e.g. T. moravicum Kratochvil, 1941), while T. forte as defined here has often been referred to by its junior synonyms T. ruginode Stitz, 1917 or T. hispanicum Bondroit, 1918. The prevalent confusion has been at least partly caused by the type material containing several taxonomic species. Thus, to achieve nomenclatural stability for this ant species after 100 years, a lectotype of T. forte is designated.
description: Published as part of Güsten, R., Schulz, A. & Sanetra, M., 2006, Redescription of Tetramorium forte Forel, 1904 (Insecta: Hymenoptera: Formicidae), a western Mediterranean ant species., pp. 1-35 in Zootaxa 1310 on page 2
title: Predicting Satisfaction With Chat-Counseling at a 24/7 Chat Hotline for the Youth
title: Natural Language Processing Study
titleType: Subtitle
Creators: name: Hornstein, Silvan
name: Lueken, Ulrike
name: Wundrack, Richard
name: Hilbert, Kevin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2025
Subjects: subject: digital mental health
subject: mental illness
subject: mental disorder
subject: adolescence
subject: chat counseling
subject: machine learning
subject: artificial intelligence
subject: large language model
subject: natural language processing
subject: deep learning
subject: 150 Psychologie

description: The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: Background: Chat-based counseling services are popular for the low-threshold provision of mental health support to youth. In addition, they are particularly suitable for the utilization of natural language processing (NLP) for improved provision of care. Objective: Consequently, this paper evaluates the feasibility of such a use case, namely, the NLP-based automated evaluation of satisfaction with the chat interaction. This preregistered approach could be used for evaluation and quality control procedures, as it is particularly relevant for those services. Methods: The consultations of 2609 young chatters (around 140,000 messages) and corresponding feedback were used to train and evaluate classifiers to predict whether a chat was perceived as helpful or not. On the one hand, we trained a word vectorizer in combination with an extreme gradient boosting (XGBoost) classifier, applying cross-validation and extensive hyperparameter tuning. On the other hand, we trained several transformer-based models, comparing model types, preprocessing, and over- and undersampling techniques. For both model types, we selected the best-performing approach on the training set for a final performance evaluation on the 522 users in the final test set. Results: The fine-tuned XGBoost classifier achieved an area under the receiver operating characteristic score of 0.69 (P<.001), as well as a Matthews correlation coefficient of 0.25 on the previously unseen test set. The selected Longformer-based model did not outperform this baseline, scoring 0.68 (P=.69). A Shapley additive explanations explainability approach suggested that help seekers rating a consultation as helpful commonly expressed their satisfaction already within the conversation. In contrast, the rejection of offered exercises predicted perceived unhelpfulness. Conclusions: Chat conversations include relevant information regarding the perceived quality of an interaction that can be used by NLP-based prediction approaches. However, to determine if the moderate predictive performance translates into meaningful service improvements requires randomized trials. Further, our results highlight the relevance of contrasting pretrained models with simpler baselines to avoid the implementation of unnecessarily complex models.
Ob dem Taufstein gegen Kärpf
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1865

description: Bleistiftzeichnung, mit geologischem Kolorit
Format: 174:215 mm
Zusätzlich vermerkt ist:
Glarus Nr. 185 a - nicht entschlüsselter Verweis oder Zusatz
XI S. 816 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Additional file 1 of Potential association of rheumatic diseases with bone mineral density and fractures: a bi-directional mendelian randomization study
Creators: name: Hong, Chen-xuan
name: Pan, Yan-zheng
name: Dai, Feng-bo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 1
Detailprofile in der Gegend Seewen-Fronalp: [kein Untertitel]
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1849

description: Federzeichnung, teilweise mit geologischem Kolorit und Bemerkungen
Format: 185:110 mm
Zusätzlich vermerkt ist:
S. 45 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Bei S. Giovanni ob Perdatsch an der Mündung des V. Cristallina
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1853

description: Federzeichnung, mit geologischem Kolorit
Format: 103:153 mm
Zusätzlich vermerkt ist:
Bünden Nr. 16 c - nicht entschlüsselter Verweis oder Zusatz
VIII S. 686 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Vom Saasberg gegen Siwellen
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Federzeichnung, teilweise mit geologischem Kolorit
Format: 128:208 mm
Zusätzlich vermerkt ist:
Glarus Nr. 107 g - nicht entschlüsselter Verweis oder Zusatz
XI S. 424 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Kerndatensatz Forschung – Inhalte, Implementation Und Unterstützungsangebote
Creators: name: Biensenbender, Sophie
Publisher: name: Zenodo
Year: 2018
Subjects: Kerndatensatz Forschung (KDSF)

description: Der Vortrag gibt einen Einblick in die Grundzüge des KDSF, seine Ziele und Prinzipien, sowie Inhalte und Struktur.
Additional file 1 of Association between life’s essential 8 and metabolic dysfunction-associated steatotic liver disease among US adults
Creators: name: Wang, Zheng
name: Huang, Bohan
name: Ding, Yixuan
name: Cao, Feng
name: Li, Fei
name: Li, Prof Fei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
Selbsanft vom Gemsifurkeli aus
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1840

description: Federzeichnung
Format: 117:176 mm
Zusätzlich vermerkt ist:
Glarus Nr. 21 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Additional file 2 of Association between life’s essential 8 and metabolic dysfunction-associated steatotic liver disease among US adults
Creators: name: Wang, Zheng
name: Huang, Bohan
name: Ding, Yixuan
name: Cao, Feng
name: Li, Fei
name: Li, Prof Fei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 2
Skizze vom Dampfschiff gegen Vitznauerstock
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1862

description: Bleistiftzeichnung
Format: 111:213 mm
Zusätzlich vermerkt ist:
Schwyz Nr. 83 c - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Additional file 2 of Assessing the value and knowledge gains from an online tick identification and tick-borne disease management course for the Southeastern United States
Creators: name: Lippi, Catherine A.
name: Gaff, Holly D.
name: White, Alexis L.
name: Ryan, Sadie J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Von der Höhe der Tömil Alp. Pass zwischen Vals u. Safien gegen SW u. W
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1837

description: Federzeichnung, aquarelliert
Format: 120:388 mm
Zusätzlich vermerkt ist:
Bünden Nr. 191 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Additional file 3 of Assessing the value and knowledge gains from an online tick identification and tick-borne disease management course for the Southeastern United States
Creators: name: Lippi, Catherine A.
name: Gaff, Holly D.
name: White, Alexis L.
name: Ryan, Sadie J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 3
Impacts of climate change on irrigation water management by the Bhumibol dam in Thailand
Creators: name: Tuantan Kitpaisalsakul
Publisher: name: Nakhon Pathom Rajabhat University
Year: 2018
Subjects: trends of climate change, irrigation water management, Bhumibol dam, Chao Phraya basin

description: Journal of Thai Interdisciplinary Research, 13, 4, 49
Tetramorium chefketi Forel
Creators: name: Güsten, R.
name: Schulz, A.
name: Sanetra, M.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium chefketi

description: Tetramorium chefketi Forel, 1911
Tetramorium caespitum var. chefketi Forel, 1911
Tetramorium chefketi Forel: Agosti & Collingwood 1987a, 1987b
According to Agosti and Collingwood (1987a), the species (misspelled “chefteki”), which was described from the European part of Turkey, occurs also in Greece and Anatolia. We compared specimens from these areas with the worker syntypes (MHNG) and support this view. Schulz (1996) presented characters differentiating T. chefketi from the closely similar T. moravicum and T. forte, and Sanetra and Buschinger (2000) as well as Schlick-Steiner et al. (2005) studied its phylogenetic position in relation to T. forte, T. moravicum and T. semilaeve. Csösz et al. (unpubl.) ascribe the paralectotypes of T. forte from Alušta (Crimea, Ukraine) to T. caespitum sarkissiani Forel, 1911 and regard that taxon as synonymous to T. chefketi, which has equal priority.
description: Published as part of Güsten, R., Schulz, A. & Sanetra, M., 2006, Redescription of Tetramorium forte Forel, 1904 (Insecta: Hymenoptera: Formicidae), a western Mediterranean ant species., pp. 1-35 in Zootaxa 1310 on page 26
Additional file 1 of Integrating virtual patients into undergraduate health professions curricula: a framework synthesis of stakeholders’ opinions based on a systematic literature review
Creators: name: Fąferek, Joanna
name: Cariou, Pierre-Louis
name: Hege, Inga
name: Mayer, Anja
name: Morin, Luc
name: Rodriguez-Molina, Daloha
name: Sousa-Pinto, Bernardo
name: Kononowicz, Andrzej A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Ob Ratzmatt in Enetseeben gegen Vrenelisgärtli. Geol. Profil
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1864

description: Federzeichnung, mit Schichtensignatur
Format: 111:175 mm
Zusätzlich vermerkt ist:
Glarus Nr. 237 a - nicht entschlüsselter Verweis oder Zusatz
XI S. 410 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Nahe unter Niederen Oberste Stafelhütte gegen Naturbrücke
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Federzeichnung, mit geologischem Kolorit
Format: 108:172 mm
Zusätzlich vermerkt ist:
Glarus Nr. 132 - nicht entschlüsselter Verweis oder Zusatz
XI S. 409 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
СОДЕРЖАНИЕ И СУЩНОСТЬ ИСПОЛЬЗОВАНИЯ ИНТЕРАКТИВНЫХ МЕТОДОВ В ПРЕПОДАВАНИИ «ВОСПИТАНИЕ» В НАЧАЛЬНЫХ КЛАССАХ
Creators: name: Иноятова, З.Х.
name: Дускулова, М.К.
Publisher: name: Zenodo
Year: 2025

description: Использование интерактивных методов в преподавании предмета «Воспитание» в начальных классах имеет большое значение для эффективного усвоения материала и формирования у детей навыков взаимодействия и сотрудничества.
Tetramorium alternans Güsten, Schulz & Sanetra, 2006, nov. stat.
Creators: name: Güsten, R.
name: Schulz, A.
name: Sanetra, M.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium alternans

description: Tetramorium alternans Santschi, 1929 nov. stat.
Tetramorium caespitum v. alternans Santschi, 1929
Cagniant (1997), treating this taxon as a subspecies of T. caespitum, cites records from diverse sites throughout Morocco. We have recently procured further samples, including the first known gyne (Morocco, Middle Atlas, Reg. Meknes, in CAS), and regard it as a good species which may occur throughout the Maghreb. Some specimens from Tunisia (in NHMB) are very similar, as are workers from the northeastern mountains of Teneriffa.
description: Published as part of Güsten, R., Schulz, A. & Sanetra, M., 2006, Redescription of Tetramorium forte Forel, 1904 (Insecta: Hymenoptera: Formicidae), a western Mediterranean ant species., pp. 1-35 in Zootaxa 1310 on page 27
Evaluating Vision Transformer Models for Visual Quality Control in Industrial Manufacturing
Creators: name: Alber, Miriam
name: Hönes, Christoph
name: Baier, Patrick
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: I.2.m

description: One of the most promising use-cases for machine learning in industrial manufacturing is the early detection of defective products using a quality control system. Such a system can save costs and reduces human errors due to the monotonous nature of visual inspections. Today, a rich body of research exists which employs machine learning methods to identify rare defective products in unbalanced visual quality control datasets. These methods typically rely on two components: A visual backbone to capture the features of the input image and an anomaly detection algorithm that decides if these features are within an expected distribution. With the rise of transformer architecture as visual backbones of choice, there exists now a great variety of different combinations of these two components, ranging all along the trade-off between detection quality and inference time. Facing this variety, practitioners in the field often have to spend a considerable amount of time on researching the right combination for their use-case at hand. Our contribution is to help practitioners with this choice by reviewing and evaluating current vision transformer models together with anomaly detection methods. For this, we chose SotA models of both disciplines, combined them and evaluated them towards the goal of having small, fast and efficient anomaly detection models suitable for industrial manufacturing. We evaluated the results of our experiments on the well-known MVTecAD and BTAD datasets. Moreover, we give guidelines for choosing a suitable model architecture for a quality control system in practice, considering given use-case and hardware constraints.
Additional file 2 of Integrating virtual patients into undergraduate health professions curricula: a framework synthesis of stakeholders’ opinions based on a systematic literature review
Creators: name: Fąferek, Joanna
name: Cariou, Pierre-Louis
name: Hege, Inga
name: Mayer, Anja
name: Morin, Luc
name: Rodriguez-Molina, Daloha
name: Sousa-Pinto, Bernardo
name: Kononowicz, Andrzej A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Von Nauders aus gegen Piz Mundin
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1850

description: Federzeichnung, teilweise mit geologischem Kolorit und Schichtensignatur
Format: 118:188 mm
Zusätzlich vermerkt ist:
Bünden Nr. 696 - nicht entschlüsselter Verweis oder Zusatz
VIII S. 46 - Hinweis auf Band/Seite der handschriftlichen Tagebücher Arnold Eschers (im Teilbestand Hs 4a)
description: ETH-Bibliothek
Tetramorium maurum Santschi
Creators: name: Güsten, R.
name: Schulz, A.
name: Sanetra, M.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium maurum

description: Tetramorium maurum Santschi, 1918
Tetramorium caespitum st. maura Santschi, 1918
Tetramorium maurum Santschi: Santschi 1929
The taxonomy of this species is unsettled: the type series contains syntypes from all three Maghreb countries and is probably heterogeneous. However, the principal collection series among the syntypes in NHMB, comprising gynes, originate from northern Tunisia. We base the comparison with T. forte on these gynes. There is currently no indication that the species occurs in Morocco.
description: Published as part of Güsten, R., Schulz, A. & Sanetra, M., 2006, Redescription of Tetramorium forte Forel, 1904 (Insecta: Hymenoptera: Formicidae), a western Mediterranean ant species., pp. 1-35 in Zootaxa 1310 on page 27
Kette der Fronalp vom Rofayen
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1840

description: Federzeichnung, teilweise mit geologischem Kolorit
Format: 130:404 mm
Zusätzlich vermerkt ist:
Uri Nr. 143 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Tetramorium caespitum
Creators: name: Güsten, R.
name: Schulz, A.
name: Sanetra, M.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium caespitum

description: “ Tetramorium caespitum sensu lato”
Species morphologically similar to T. caespitum (Linnaeus, 1758) are the dominant Tetramorium ants in temperate parts of Eurasia. Cammaerts et al. (1985) distinguished T. impurum (Foerster, 1850) from T. caespitum in central Europe based on male genitalic characters. It has recently become clear that the T. caespitum / impurum species complex constitutes in fact an assembly of cryptic species, which cannot yet be delimited clearly or assigned valid names (Steiner et al. 2002; Schlick-Steiner et al., 2006). More than one species is included within the current concepts of both T. caespitum and T. impurum. Throughout this paper we use the term “ T. caespitum s.l.” to denote species of the complex.
description: Published as part of Güsten, R., Schulz, A. & Sanetra, M., 2006, Redescription of Tetramorium forte Forel, 1904 (Insecta: Hymenoptera: Formicidae), a western Mediterranean ant species., pp. 1-35 in Zootaxa 1310 on page 27
Additional file 3 of Integrating virtual patients into undergraduate health professions curricula: a framework synthesis of stakeholders’ opinions based on a systematic literature review
Creators: name: Fąferek, Joanna
name: Cariou, Pierre-Louis
name: Hege, Inga
name: Mayer, Anja
name: Morin, Luc
name: Rodriguez-Molina, Daloha
name: Sousa-Pinto, Bernardo
name: Kononowicz, Andrzej A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 3
Grosse Mÿthe : von Alp Holzegg
Creators: name: Heim, Albert
name: Müller, Johann
Publisher: name: [s.n.]
Year: 1860
Subjects: Berg

description: Copie nach A. Heim ; IM.
description: Unterhalb des Titels: "NB oberst. Spitze ist nicht sichtbar"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Das Publikationsdatenmanagement Und Das Forschungsinformationssystem An Der Uni Göttingen. Ein Bericht Aus Sicht Der Sub Göttingen
Creators: name: Beucke, Daniel
Publisher: name: Zenodo
Year: 2018
Subjects: Forschungsinformationssystem

description: Der Vortrag gibt einen Einblick in das Forschungsinformationssystem der SUB Göttingen.
Measuring the Magnetic Field Amplitude of rf Radiation by the Quasistatic Magnetic Field Effect in Organic Light-Emitting Diodes
Creators: name: Grünbaum, Tobias
name: Bange, Sebastian
name: Jiang, Wei
name: Leung, Anna E.
name: Darwish, Tamim A.
name: Burn, Paul L.
name: Lupton, John M.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ROOM-TEMPERATURE; MAGNETORESISTANCE; POLYMER
subject: 530 Physik

description: Electron paramagnetic resonance (EPR) is a versatile tool to probe spin physics in organic semiconductor materials. A common method used to detect the spin-%2 paramagnetic resonance in organic light-emitting diodes (OLEDs) is to measure the device resistance under EPR conditions, i.e., to record electrically detected magnetic resonance (EDMR). Here, we present ultralow-frequency EDMR experiments on OLEDs that exhibit a qualitatively new line shape because of a quasistatic magnetic field effect: the modulation of the static ultrasmall field-effect magnetoresistance arising from the magnetic field amplitude B1 of the radio frequency (rf) radiation. The disappearance of spin-%2 Zeeman resonances of individual charge carriers in the OLED, i.e., the resonances at magnetic fields where the Zeeman splitting matches the photon energy of the incident rf radiation, coincides with the emergence of the quasistatic effect. We discuss the origin of this quasistatic magnetic field effect, its characteristic line shape in terms of the magnetic field dependence, the influence of experimental parameters, and the application potential with regards to EDMR experiments. The EDMR line shape can be inferred numerically from the magnetoresistance measurements. This approach enables a unique means of determining the drive-field strength B1 in EDMR under driving conditions where alternative methods employing an analysis of the Zeeman resonance-such as power broadening and Rabi flopping-are not applicable.
Skizze vom Mürtschenstock u. Stockloch: Mürtschenstock Ost-Abfall
Creators: name: Escher von der Linth, Arnold
Publisher: name: [s.n.]
Year: 1827

description: Bleistift- und Federzeichnung
Format: 217:142 mm
Zusätzlich vermerkt ist:
Glarus Nr. 420 - nicht entschlüsselter Verweis oder Zusatz
description: ETH-Bibliothek
Insulin and IGF-1 receptor autocrine loops are not required for Exendin 4.pdf
Creators: name: Cruzat, Vinicius
Publisher: name: Figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 7.0px Times}
span.s1 {font: 7.0px Helvetica}

Pharmacological long lasting Glucagon-like peptide-1 (GLP-1) analogues, such as Exendin-4, have become
widely used diabetes therapies. Chronic GLP-1R stimulation has been linked to β-cell protection and these prosurvival
actions of GLP-1 are dependent on the activation of the mammalian target of rapamycin (mTOR) leading
to accumulation of Hypoxia inducible factor 1 alpha (HIF-1α). Recent studies from our lab indicate that prolonged
GLP-1R stimulation promotes metabolic reprograming of β-cells towards a highly glycolytic phenotype
and activation of the mTOR/HIF-1α pathway was required for this action. We hypothesised that GLP-1 induced
metabolic changes depend on the activation of mTOR and HIF-1α, in a cascade that occurs after triggering of a
potential Insulin-like growth factor 1 receptor (IGF-1R) or the Insulin receptor (IR) autocrine loops. Loss of
function of these receptors, through the use of small interfering RNA, or neutralizing antibodies directed towards
their products, was undertaken in conjunction with functional assays. Neither of these strategies mitigated the
effect of GLP-1 on glucose uptake, protein expression or bioenergetic flux. Our data indicates that activation of
IGF-1R and/or the IR autocrine loops resulting in β-cell protection and function, involve mechanisms independent
to the enhanced metabolic effects resulting from sustained GLP-1R activation.