cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation von Gebrauch und Wirkung der Verbandsklagemöglichkeiten nach dem Umwelt-Rechtsbehelfsgesetz (UmwRG)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Umwelt-Rechtsbehelfsgesetz
subject: Verbandsklage
subject: Gesetzesfolgenabschätzung
subject: Umweltverträglichkeitsprüfung
subject: Umweltrecht
subject: Verbandsklagerecht
subject: Umweltrechtsbehelfsgesetz
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Im Mittelpunkt des Projektes steht die Frage, inwieweit Rechtsbehelfe aufgrund des UmwRG - und auch bereits die Möglichkeit, solche einzulegen - dazu beitragen, dass bei der Konzeption eines Vorhabens, im Verwaltungsverfahren oder durch das Ergebnis des eigentlichen Rechtsbehelfsverfahrens bei Gericht eine vollständigere Berücksichtigung von materiellen und prozeduralen umweltrechtlichen Vorgaben erfolgt, als dies ohne die im Kontext des UmwRG erfolgte Mitwirkung eines Verbandes der Fall gewesen wäre.
Quelle: www.umweltbundesamt.de

description: Im Mittelpunkt des Projektes steht die Frage, inwieweit Rechtsbehelfe aufgrund des UmwRG – und auch bereits die Möglichkeit, solche einzulegen – dazu beitragen, dass bei der Konzeption eines Vorhabens, im Verwaltungsverfahren oder durch das Ergebnis des eigentlichen Rechtsbehelfsverfahrens bei Gericht eine vollständigere Berücksichtigung von materiellen und prozeduralen umweltrechtlichen Vorgaben erfolgt, als dies ohne die im Kontext des UmwRG erfolgte Mitwirkung eines Verbandes der Fall gewesen wäre.
Keeping Pace with the Red Queen : Identifying the Genetic Basis of Susceptibility to Infectious Disease
Creators: name: MacPherson, Ailene
name: Otto, Sarah P., 1967-
name: Nuismer, Scott L.
Publisher: name: The University of British Columbia
Year: 2020

description: Genome-wide association studies are widely used to identify “disease genes” conferring resistance/susceptibility to infectious diseases. Using a combination of mathematical models and simulations, we demonstrate that genetic interactions between hosts and parasites [genotype-by-genotype (G 3 G) interactions] can drastically affect the results of these association scans and hamper our ability to detect genetic variation in susceptibility. When hosts and parasites coevolve, these G 3 G interactions often make genome-wide association studies unrepeatable over time or across host populations. Reanalyzing previously published data on Daphnia magna susceptibility to infection by Pasteuria ramosa, we identify genomic regions consistent with G 3 G interactions. We conclude by outlining possible avenues for designing more powerful and more repeatable association studies.
'You fight like a girl': Intimate partner abuse perpetration and recidivism amongst Australian women
Creators: name: Nazarewicz, Julia
Publisher: name: Swinburne
Year: 2024

description: Compared to men, little is known about the women who come to police attention for the perpetration of intimate partner abuse. This thesis investigated patterns in the contacts women have with police for both family violence victimisation and perpetration, compared the risk factors associated with repeat police contact for intimate partner abuse in men and women, and studied the psychometric properties of three existing risk assessment tools when used by police with female perpetrators. The results add to a growing understanding of the heterogeneous nature of female intimate partner abuse and how police might assess risk in this area.
Designing and Fabricating a Prototype Air-Powered Remote-Control Car
Creators: name: Cook, Alan
name: Perkins, Adam
Publisher: name: Unknown
Year: 2025
Subjects: subject: Compressed air
subject: air-powered
subject: compressed air
subject: remote-control
subject: car

description: The objective of this project is to develop a prototype air-powered remote-controlled (RC) vehicle that demonstrates the viability and potential advantages of a compressed air-powered drivetrain. The Air-Powered RC Car (APRCC) is uniquely characterized by the integration of subsystems that closely replicate those found in full-scale automobiles. This design approach provides a more complex and realistic driving experience, while also enabling increased opportunities for user-driven mechanical tuning and experimentation. The development of the compressed air engine was guided by prior work related to pneumatic propulsion systems. Given the experimental and evolving nature of this project, it was essential to adopt an iterative design approach. This methodology involved repeated cycles of prototyping, testing, and refinement, which necessitated the extensive use of 3D-printed components to enable rapid fabrication and modification of parts throughout the development process. The project team executed the complete design, fabrication, and assembly of the APRCC. Performance testing of the finalized prototype yielded a maximum runtime of 60 seconds and a peak velocity of 5 miles per hour.
Stability of remission rates in a 3-year follow-up of naturalistic treated depressed inpatients
Creators: name: Seemueller, Florian
name: Obermeier, Michael
name: Schennach, Rebecca
name: Bauer, Michael
name: Adli, Mazda
name: Brieger, Peter
name: Laux, Gerd
name: Riedel, Michael
name: Falkai, Peter
name: Moeller, Hans-Juergen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Remission is a common outcome of short-term trials and the main goal of acute and longterm treatment. The longitudinal stability of remission has rarely been investigated under naturalistic treatment conditions. Methods Naturalistic multisite follow-up study. Three-year symptomatic long-term outcome of initially hospitalized tertiary care patients (N = 784) with major depressive episodes. Remission rates as well as the switch rates between remission and non-remission were reported. Results After one, two and three years 62 %, 59 % and 69 % of the observed patients met criteria for remission. During the follow-up 88 % of all patients achieved remission. 36 % of maintained remission from discharge to 3-years, 12 % of all patients never reached remission and 52 % percent showed a fluctuating course switching from remission to non-remission and vice versa. There was considerable transition between remission and non-remission. For example, from discharge to 1 year, from 1 to 2, and from 2 to 3 years 25 %, 21 % and 11 % lost remission. Conclusion Cumulative outcome rates are encouraging. Absolute rates at predefined endpoints as well as the fluctuations between these outcomes reflect the variable and chronic nature of major depression.
3793284.pdf
Creators: name: Metcalf, Andrew
name: Anderson, Tyler
name: Bender, Chad
name: Blakeslee, Scott
name: Brand, Wesley
name: Carlson, David
name: Cochran, William
name: Diddams, Scott
name: endl, michael
name: Fredrick, Connor
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplemental text
Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis
Creators: name: Hewing, Bernd
name: Ludwig, Antje
name: Pötzsch, Max
name: Hannemann, Carmen
name: Petry, Andreas
name: Lauer, Dilyara
name: Görlach, Agnes
name: Kaschina, Elena
name: Müller, Dominik N.
name: Baumann, Gert
name: Stangl, Verena
name: Stangl, Karl
name: Wilck, Nicola
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Atherosclerosis
subject: Peripheral vascular disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Management of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis under cytokine induced oxidative stress. The present study aimed to investigate the effect of β5i/LMP7-deficiency on the initiation and progression of atherosclerosis as a chronic inflammatory, immune cell driven disease. LDLR−/−LMP7−/− and LDLR−/− mice were fed a Western-type diet for either 6 or 24 weeks to induce early and advanced stage atherosclerosis, respectively. Lesion burden was similar between genotypes in both stages. Macrophage content and abundance of polyubiquitin conjugates in aortic root plaques were unaltered by β5i/LMP7-deficiency. In vitro experiments using bone marrow-derived macrophages (BMDM) showed that β5i/LMP7-deficiency did not influence macrophage polarization or accumulation of polyubiquitinated proteins and cell survival upon hydrogen peroxide and interferon-γ treatment. Analyses of proteasome core particle composition by Western blot revealed incorporation of standard proteasome subunits in β5i/LMP7-deficient BMDM and spleen. Chymotrypsin-, trypsin- and caspase-like activities assessed by using short fluorogenic peptides in BMDM whole cell lysates were similar in both genotypes. Taken together, deficiency of IP subunit β5i/LMP7 does not disturb protein homeostasis and does not aggravate atherogenesis in LDLR−/− mice.
Aktueller Gewässerzustand und Wasserkraftnutzung
Creators: name: Naumann, Stephan
Publisher: name: My University
Year: 2022
Subjects: EG-Wasserrahmenrichtlinie
Maßnahmenprogramm
Wasserkraft

description: Mit der Veröffentlichung der Bewirtschaftungspläne und Maßnahmenprogramme für die zehn deutschen Flussgebietseinheiten hat der dritte Bewirtschaftungszeitraum zur Umsetzung der WRRL begonnen und die aktuellen Erkenntnisse zum Gewässerzustand liegen vor. In Deutschland werden die Ziele der Wasserrahmenrichtlinie (WRRL) weiterhin großräumig verfehlt und es müssen Fristverlängerungen bis zur Zielerreichung in Anspruch genommen werden. Die häufigsten Ursachen, durch die die Ziele der WRRL verfehlt werden, sind veränderte Gewässerstrukturen, fehlende Durchgängigkeit sowie zu hohe Nähr- und Schadstoffbelastungen. Für diese Belastungen sind verschiedenste Nutzungen verantwortlich. Aus der Berichterstattung für die Umsetzung der WRRL wird jedoch auch deutlich, dass die Wasserkraft bundesweit maßgeblich zur signifikanten Gewässerbelastung beiträgt. In dem u. a. von der Wasserkraftnutzung belasteten Teil des Gewässernetzes werden die Ziele der WRRL derzeit zu 95 Prozent verfehlt. In zahlreichen Wasserkörpern müssen daher in den kommenden Jahren Maßnahmen zur Verbesserung der Durchgängigkeit, der Mindestwasserführung, der hydrologischen Situation und für den Fischschutz umgesetzt werden. Quelle: Korrespondenz Wasserwirtschaft
The impact of climate change on flood frequency distributions: A case study of the Kemptville Creek watershed
Creators: name: Ramsay, Andrea
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Engineering, Geological.
subject: Engineering, Civil.

description: Distributions of future extreme hydrologic events represent a major concern in the context of climate change and its potential impacts. The accurate inference of their probability distribution for a given period (present or future) is crucial for the safe and economic design of a range of engineering works, from hydraulic structures such as dam spillways and bridges, to flow routing infrastructure such as culverts, stormwater ponds and channels. These distributions are likely to evolve with climate change and the development of methods to estimate possible impacts on extreme event distributions has become a key area of study. In this study the impact of climate change on flood frequency distributions is ascertained through a combination of physical modeling and statistical analysis. This approach utilizes two of the most valuable tools in the field; general circulation models (GCMs) and non-stationary extreme value analysis, and seeks to capitalize on the strengths of established methods while limiting the number of unnecessary assumptions.
Galaxy Cluster Mass Reconstruction Project - II. Quantifying scatter and bias using contrasting mock catalogues
Creators: name: Old, L.
name: Wojtak, R.
name: Mamon, G. A.
name: Skibba, R. A.
name: Pearce, F. R.
name: Croton, Darren
name: Bamford, S.
name: Behroozi, P.
name: de Carvalho, R.
name: Muñoz-Cuartas, J. C.
name: Gifford, D.
name: Gray, M. E.
name: von der Linden, A.
name: Merrifield, M. R.
name: Muldrew, S. I.
name: Müller, V.
name: Pearson, R. J.
name: Ponman, T. J.
name: Rozo, E.
name: Rykoff, E.
name: Saro, A.
name: Sepp, T.
name: Sifón, C.
name: Tempel, E.
Publisher: name: Swinburne
Year: 2024

description: This article is the second in a series in which we perform an extensive comparison of various galaxy-based cluster mass estimation techniques that utilise the positions, velocities and colours of galaxies. Our aim is to quantify the scatter, systematic bias and completeness of cluster masses derived from a diverse set of 25 galaxy-based methods using two contrasting mock galaxy catalogues based on a sophisticated halo occupation model and a semi-analytic model. Analysing 968 clusters, we find a wide range in the RMS errors in log M200c delivered by the different methods (0.18 to 1.08 dex, i.e., a factor of ~1.5 to 12), with abundance matching and richness methods providing the best results, irrespective of the input model assumptions. In addition, certain methods produce a significant number of catastrophic cases where the mass is under- or over-estimated by a factor greater than 10. Given the steeply falling high-mass end of the cluster mass function, we recommend that richness or abundance matching-based methods are used in conjunction with these methods as a sanity check for studies selecting high mass clusters. We see a stronger correlation of the recovered to input number of galaxies for both catalogues in comparison with the group/cluster mass, however, this does not guarantee that the correct member galaxies are being selected. We do not observe significantly higher scatter for either mock galaxy catalogues. Our results have implications for cosmological analyses that utilise the masses, richnesses, or abundances of clusters, which have different uncertainties when different methods are used.
The association between undergraduate majors and substance use and how mental health status affects that relationship
Creators: name: Amish-Malik, Mohammed
Publisher: name: University of Iowa
Year: 2024

description: Previous findings demonstrate variability in substance use among undergraduate majors and demonstrate significant relationships between mental health status and substance use. However, there is a gap in the literature on whether mental health status plays a role in the relationship between college majors and substance use. This epidemiological study, which aims to address that gap, examined the relationship between major and substance use as the first goal. Its secondary goal was to examine how that relationship changed when accounting for mental health status. The study data stems from the Healthy Minds Survey, which is a public and cross-sectional dataset. Arts & Humanities, STEM, Business, Education, and Social Sciences, Health, and Undecided and Other college majors were considered, with STEM used as the reference group. Substance use was defined as stimulants, opioids, hallucinogens, binge drinking, marijuana, cigarettes or vaping (nicotine), kratom, and benzodiazepines. Mental health status was operationalized as two types of variables: mental health symptom scales and mental health diagnoses. This study utilized logistic regression, focusing on a yes/no outcome for each substance by undergraduate major. Two categories of models were created: one that did not adjust for mental health variables, which included the mental health symptom scales and mental health diagnoses and mental health treatment, and another that did. Covariates that were in both models included variables capturing demographics which included but were not limited to family education level, chronic disease conditions, age, sexual orientation, and gender. Other covariates included chronic health conditions and substance use screening questions. There were statistical differences in the rate of substance use across majors. The relationship between undergraduate majors and substance use had inconsistent variations when adjusted for mental health status. In general, the associations between undergraduate major and substance use were relatively stable with and without adjustment for mental health. This suggests that mental health does not play a substantial role in the relationship of undergraduate majors and substance use.
Kommunale, nicht-investive Maßnahmen im Verkehr
Creators: name: Kurzweil, Agnes
name: Raimund, Willy
name: Ansbacher, Patrick
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Nachhaltige Mobilität
subject: Ökonomische Instrumente
subject: Nicht-investive Maßnahmen
subject: Kampagnen
subject: Anreize
subject: Verhaltensveränderung
subject: Rechtliche Instrumente
subject: Verkehr

description: Mobilität bestimmt unser Leben und unsere Lebensqualität in hohem Ausmaß. Doch auch wir beeinflussen mit unserem Verhalten das Verkehrsgeschehen massiv. Der Verkehr trägt mit seinen Treibhausgasemissionen maßgeblich zur Klima- und Erderwärmung bei. Um die negativen Auswirkungen des Verkehrs zu adressieren, bedarf es eines umfassenden Bündels an Maßnahmen. Vor diesem Hintergrund initiierte das Umweltbundesamt das Forschungsvorhaben "Ökologische Wirkungsanalyse kommunaler, nicht-investiver Maßnahmen im Verkehr". Es setzt den Schwerpunkt auf Verkehrsmaßnahmen, die im nicht-investiven Bereich angesiedelt sind. Die vorliegende Broschüre stellt diese anhand von Beispielen aus der Praxis dar. Quelle: www.umweltbundesamt.de
description: Mobilität bestimmt unser Leben und unsere Lebensqualität in hohem Ausmaß. Doch auch wir beeinflussen mit unserem Verhalten das Verkehrsgeschehen massiv. Der Verkehr trägt mit seinen Treibhausgasemissionen maßgeblich zur ⁠Klima⁠- und Erderwärmung bei. Um die negativen Auswirkungen des Verkehrs zu adressieren, bedarf es eines umfassenden Bündels an Maßnahmen.Vor diesem Hintergrund initiierte das Umweltbundesamt das Forschungsvorhaben „Ökologische Wirkungsanalyse kommunaler, nicht-investiver Maßnahmen im Verkehr“. Es setzt den Schwerpunkt auf Verkehrsmaßnahmen, die im nicht-investiven Bereich angesiedelt sind. Die vorliegende Broschüre stellt diese anhand von Beispielen aus der Praxis dar.
Laminated carbon fibre reinforced composites for energy storage
Creators: name: Chan, Kit-Ying
Publisher: name: Swinburne
Year: 2024

description: Electric vehicles (EVs) have great potential to ease the environmental issues. However, current EVs have a limited range, reducing their appeal and hence their impacts. This research is to develop a new composite for energy storage by using carbon fibre reinforced composites (CFRPs) as electrodes and graphene oxide (GO) film as a dielectric separator. The composite is capable of carrying mechanical loads and storing electrical energy simultaneously. The composite can be used as the primary structural components in EVs and integrated with renewable energy technologies, in particular photovoltaics. In the near future, EVs can be powered by totally green power.
Effect of ischemia/reperfusion on the rat intrarenal renin-angiotensin system.
Creators: name: Kontogiannis, Jimmy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Animal Physiology.

description: Proliferation and differentiation of tubular cells occur after renal ischemia/reperfusion. Angiotensin II has multiple growth effects on different renal cell types, and also regulates renal blood flow In particular, proximal tubular cells locally synthesize angiotensin II, which can bind to AT$\sb1$ receptors in an autocrine/paracrine fashion. The function of the AT$\sb2$ receptor is unknown, but is linked to apoptosis in other tissues. In the current study, gene expression for intrarenal angiotensinogen, cortical AT$\sb1$ receptor and proximal tubular AT$\sb1$ receptor was determined by Northern blots, and gene expression for the AT$\sb2$ receptor was determined by RT-PCR. In rats after ischemia/reperfusion. A significant downregulation of angiotensinogen mRNA occurred from 6 to 72 hours post-ischemia/reperfusion, whereas the cortical AT$\sb1$ receptor did not change significantly. In contrast, proximal tubular AT$\sb1$ receptor mRNA significantly decreased from 0 to 24 hours post-ischemia/reperfusion, and recovered after 72 hours. New gene expression for the AT$\sb2$ receptor was observed in ischemic proximal tubular segments and in the ischemic outer medulla 120 hours after ischemia/reperfusion. By histoautoradiography, a significant decrease in the density of angiotensin II binding was noted in the ischemic cortex after 24 hours post-ischemia/reperfusion, and in the outer medulla at 3 and 24 hours. At 120 hours post-ischemia/reperfusion, intrarenal angiotensin II levels, density of angiotensin II binding and angiotensinogen gene expression recovered. In conclusion, the intrarenal renin-angiotensin system is downregulated with ischemia/reperfusion, and recovers 120 hours post-ischemia/reperfusion, with co-expression of AT$\sb1$ and AT$\sb2$ receptor mRNA at this time. These findings suggest that co-expression of AT$\sb1$ and AT$\sb2$ receptors may be involved in the remodelling of injured tissue.
Impact of DNA Damage on the Frequency of Sperm Chromosomal Aneuploidy in Normal and Subfertile Men
Creators: name: Alizadeh Nili, Hamid
name: Mozdarani, Hossein
name: Pellestor, Franck
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Determinants of Injury and Death in Canadian Firefighters : A Case for a National Firefighter Wellness Surveillance System
Creators: name: Ramsden, Rachel
name: Smith, Jennifer
name: Turcotte, Kate
name: Garis, Len
name: Kunz, Kenneth
name: Maxim, Paul
name: Thomas, Larry
name: Pike, Ian, 1958-
Publisher: name: The University of British Columbia
Year: 2021

description: Occupational injury is a significant concern facing the Canadian workforce resulting in lost work time and income, medical expenses, compensation costs, and long-term health problems or disability. Previous research has shown health risks associated with employment as a firefighter, and exposure to a variety of injury-related hazards in the course of their occupation. Extreme temperatures, toxic substances, strenuous physical labour, violence and other traumatic events are potential risks that firefighters may experience when responding to emergencysituations. The purpose of this report is to describe injury, disease and death among Canadian firefighters. The report aims to help the reader to understand the causes of injury, disease and death among Canadian firefighters through an extensive review of previous research, as well as a detailed analysis of injury claims data. Claims data from the Association of Workers’ Compensation Boards of Canada (AWCBC) and WorkSafeBC for the years 2006 to 2015 for professional and volunteer firefighters are presented to define priority issues for targeted health promotion and injury prevention interventions.
Vitamin D Supplementation and Hemoglobin Levels in Hypertensive Patients
Creators: name: Ernst, Jana B.
name: Tomaschitz, Andreas
name: Grübler, Martin R.
name: Gaksch, Martin
name: Kienreich, Katharina
name: Verheyen, Nicolas
name: März, Winfried
name: Pilz, Stefan
name: Zittermann, Armin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Epidemiological evidence suggests that circulating 25-hydroxyvitamin D (25OHD) levels are inversely associated with hemoglobin (Hb) levels and anemia risk. We evaluated whether vitamin D supplementation improves Hb levels and reduces anemia risk in hypertensive patients. Two hundred patients with 25OHD levels <75 nmol/L who attended the Styrian Vitamin D Hypertension Trial were included, of whom 188 completed the trial. Patients randomly received 2800 IU vitamin D3 daily or a matching placebo for eight weeks. Initially, the prevalence of anemic status (Hb levels <12.5 g/dL) and deficient 25OHD levels (<30 nmol/L) was 6.5% and 7.5%, respectively. All anemic patients had 25OHD levels >50 nmol/L. The mean (95% confidence interval) vitamin D effect on Hb levels was 0.04 (−0.14 to 0.22) g/dL (). Moreover, vitamin D treatment did not influence anemic status significantly (). Likewise, vitamin D had no significant effect on Hb levels in the subgroups of anemic patients or in patients with initial 25OHD levels <30 nmol/L. In conclusion, a daily vitamin D supplement of 2800 IU for eight weeks did not improve Hb levels or anemic status in hypertensive patients. Future trials should focus on anemic patients with deficient 25OHD levels (e.g., <30 nmol/L). This trial is registered with clinicaltrials.gov [NCT02136771].
Superfield supergravity and an almost no-scale scenario
Creators: name: Wonsak, Bjoern Soenke
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2004
Subjects: thesis
supergravity
supersymmetry: superfield
supersymmetry: symmetry breaking
spontaneous symmetry breaking
energy: Casimir
group theory: space-time
group theory: representation
bibliography

description: Universität Hamburg, Diplomarbeit, 2004; 70 pp., (2004). doi:10.3204/DESY-THESIS-2004-010
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Entstehung topologischer Defekte am Ende der Inflation
Creators: name: Janutta, Benjamin
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2004
Subjects: thesis
inflation: hybrid
defect: topological
critical phenomena
spontaneous symmetry breaking
supersymmetry
symmetry: Z(2)
vacuum state: decay
inflaton: fluctuation
tachyon
preheating
numerical calculations

description: Universität Hamburg, Diplomarbeit, 2004; 57 pp., (2004). doi:10.3204/DESY-THESIS-2004-051
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
The human subthalamic nucleus inhibits neural representations of attentional engagement
Creators: name: Soh, Cheol
Publisher: name: University of Iowa
Year: 2023
Subjects: Hyperdirect Pathway
Inhibition
Selective Attention
Steady State Visual Evoked Potential
Subthtlamic Nucleus
public abstract

description: The subthalamic nucleus (STN) of the basal ganglia is key to the inhibitory control of movement (Jahanshahi et al., 2015). Accordingly, it is a primary target for the neurosurgical treatment of movement disorders like Parkinson’s Disease, where modulating the STN via deep-brain stimulation (DBS) can release excess inhibition of thalamo-cortical motor circuits (Benabid et al., 2009; Lofredi et al., 2021; Wessel et al., 2022). However, the STN is also anatomically connected to other thalamo-cortical circuits, including those underlying cognitive processes like attention (Haynes & Haber, 2013; Bingham et al., 2023). This suggests that the STN may also contribute to the inhibition of those processes. We here tested this hypothesis in humans. We used a novel, wireless outpatient method to record intracranial local field potentials from STN DBS implants (Gilron et al., 2021; Feldmann et al., 2022) during a visual attention task (Soh & Wessel, 2021). We also modulated STN via DBS. In both cases, we simultaneously recorded high-density EEG to extract the steady-state visual evoked potential (SSVEP), a neural measure of visual attentional engagement (Muller et al., 1998). Introducing unexpected, distracting sounds lead to a momentary reduction of this SSVEP. This suppression was preceded by sound-related γ-frequency (>60Hz) activity in STN, which scaled with each sound’s surprisal value. The STN activity statistically mediated the suppressive effect of surprisal on the SSVEP. Finally, modulating STN activity via DBS reduced the sound-related SSVEP-suppression. Together, these findings provide the first causal evidence that the human STN contributes to the inhibition of attention, a non-motor process. Beyond their support for a domain-general inhibitory role of the STN, these findings also suggest a mechanism underlying known cognitive side-effects of STN DBS (Parsons et al., 2006; Heo et al., 2008; Combs et al., 2015).
The role and regulation of Flice-Like Inhibitory Protein (FLIP) in cisplatin resistance in human ovarian cancer cells in vitro
Creators: name: Abedini, Mohammad Reza
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Health Sciences, Oncology.

description: Human ovarian cancer is the most lethal gynecological malignancy. Although cisplatin (CDDP) and paclitaxel are the first-line chemotherapeutic agents for ovarian cancer, chemoresistance is a major therapeutic problem with mechanisms involved still not well understood. Dysregulation of the apoptotic cascade may be a causative factor for chemoresistance. Indeed gene products involved in the regulation of apoptosis, including the PI3K/Akt and Flice-Like Inhibitory Protein (FLIP) are frequently over-expressed and/or dysregulated in chemoresistant cells. FLIP, a caspase-8 analogue, modulates death receptor-mediated apoptosis by preventing caspase-8 activation. Since FLIP may have a critical involvement in ovarian cancer chemoresistance, it is importance to understand its role, the molecular and cellular mechanisms by which FLIP is regulated, and if and how dysregulated FLIP degradation is involved in the etiology of chemoresistance. Human ovarian cancer cell lines were used to establish the possible involvement of FLIP in the regulation of CDDP sensitivity in vitro and to assess the mechanism by which CDDP regulates FLIP. We demonstrated that CDDP down-regulates FLIP content, induces caspase-8 and -3 activation and apoptosis in chemosensitive ovarian cancer cells, but not in their resistant counterparts. Moreover, we observed that FLIP over-expression in chemosensitive cells attenuates CDDP sensitivity, while FLIP down-regulation sensitizes chemoresistant cells to CDDP. We further demonstrated that CDDP had no effects on FLIP mRNA abundance but down-regulated FLIP protein content in chemosensitive cells, a response attenuated by proteasome inhibitors. Itch is an E3 ligase protein involved in protein ubiquitination. CDDP also enhances FLIP-p53-Itch cell membrane co-localization, and FLIP ubiquitination in chemosensitive but not resistance cells. In addition, Itch silencing attenuates CDDP-induced FLIP ubiquitination. p53 siRNA also attenuates FLIP-Itch and FLIP-p53 interactions and FLIP ubiquitination. While Akt activation inhibits CDDP-induced FLIP degradation and apoptosis in chemosensitive cells, these responses are facilitated by dominant-negative Akt expression in their resistant variants. Finally, p53 siRNA attenuates CDDP-induced and dominant negative (DN)-Akt-facilitated FLIP-p53 binding and FLIP ubiquitination in resistant cells. These studies improve our understanding of FLIP involvement in chemoresistance, the mechanism by which CDDP regulates FLIP, and dysregulation of FLIP degradation in chemoresistance in ovarian cancer.
Umweltrelevante Produktinformationen im E-Commerce - Chancen für nachhaltigen Konsum (Anhang)
Creators: name: Hagemann, Helmut
Publisher: name: My University
Year: 2015
Subjects: subject: Einzelhandel
subject: Informationsgewinnung
subject: Informationsmanagement
subject: Konsumverhalten
subject: Marktforschung
subject: Nachhaltiger Konsum
subject: Produktbewertung
subject: Handlungsempfehlungen
subject: Internetangebote
subject: Kaufentscheidung
subject: Onlinehandel
subject: Umweltbezogene Produktkennzeichnung
subject: Produktvergleich
subject: Umweltbewusstes Konsumverhalten
subject: Umweltzeichen
subject: Blauer Engel
subject: Verbraucherinformation
subject: Verbraucherverhalten
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Das Pilotprojekt hat die Informationsrealitäten und Handlungsbedingungen im E-Commerce untersucht und im Dialog mit Unternehmen Ansätze zur besseren Ausschöpfung der Handlungsmöglichkeiten sondiert. Für das Umweltzeichen „Der Blaue Engel“ wurde eine Online-Produktdatenbank entwickelt und im Einsatz durch Preisvergleichsmaschinen erprobt. Zudem wurde ein Rechtsgutachten zu den Handlungsmöglichkeiten des E-Commerce vorgelegt. Zur weiteren, systematischen Verbesserung der ökologischen Produktinformation im E-Commerce empfiehlt sich ein staatliches Engagement insbesondere in den Bereichen Datenzugang, Kapazitätsentwicklung, Definition von Qualitätsanforderungen und ⁠Monitoring⁠.
Knowledge discovery for behavioral patterns in wireless sensor networks
Creators: name: Samarah, Samer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Engineering, Electronics and Electrical.
subject: Computer Science.

description: The research consolidated in this thesis is motivated by the recent evolvement of wireless technologies and microelectronic devices, which instigated the emergence of Wireless Sensor Networks (WSNs). Many WSN-based applications have come about; these applications are related, but not limited, to the fields of military, environment and health care. Research in WSNs is still in its early stages, and efforts have been put forward to design fast, reliable, and fault-tolerant protocols that guarantee acceptable levels of quality for events delivery, to meet the limited capabilities of sensor nodes and the effects of unreliable wireless communication. In this thesis, we focus on the design of a Knowledge-based framework for extracting behavioral patterns regarding sensor nodes from WSNs. Three types of behavioral patterns are introduced: Sensor Association Rules, Coverage-based Rules and Sensor Chronological Patterns. The proper steps in the Knowledge Discovery process that pertain to the extraction of the behavioral patterns are defined. These steps are: (i) a formal definition of the required 'knowledge'; (ii) the data preparation stage that covers the communication aspects of the process of preparing data that is needed to extract these patterns; (iii) the data mining techniques that are essential for extracting the required patterns. A set of schemes have been proposed to attain these steps, and meet the critical properties of WSNs. In contrast to other techniques, the proposed behavioral patterns are mainly about the sensor nodes, instead of the area under monitoring. The direct application of the proposed patterns is enhancing the performance of WSNs by participating in the resource management process of sensor nodes, and reducing the undesired cons of wireless communication; thus improving the Quality of Service of WSNs. Several experiments have been conducted, using synthetic and real data, to report about the performance of proposed schemes.
title: A hierarchy of sound discrimination
title: evidence from eye-tracking in the Visual World Paradigm
titleType: Subtitle
Creators: name: Lee, Nadine
Publisher: name: University of Iowa
Year: 2023
Subjects: auditory training
eye-tracking
phonemic contrasts
speech perception
word recognition
public abstract

description: Purpose: Many studies have demonstrated that Auditory Training for adult cochlear implant (CI) users is beneficial for overall speech perception. Currently, Auditory Training involves teaching perceptual distinctions of sounds based on which phonemes are easier/harder to discriminate. However, there is a lack of evidence to support the validity of the hierarchy in which Auditory Training currently instructs adult CI users. The objective of the current study is to implement psycholinguistic theories and methods to explore how typical hearing listeners discriminate phonemes within the conditions of place of articulation, manner of articulation, voicing, and nasality.
description: Method: Given a display of four images: a target (e.g., lab), a cohort (e.g., lamb), an unrelated item (e.g., ditch), and another unrelated item (e.g., dish), participants (n = 30) clicked on the image that corresponded to the target word they heard.
description: Results: We found that listeners demonstrated a higher proportion of looking given a target word within the conditions of place of articulation and manner of articulation relative to voicing and nasality.
description: Conclusion: These results suggest that psycholinguistic theories and models can be used as evidence to create a hierarchy of phoneme discrimination as it relates to auditory training in cochlear implant users.
Wirkungs- und Lokalitätsprinzip für nichtkommutative skalare Feldtheorien
Creators: name: Zahn, Jochen
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003
Subjects: thesis
axiomatic field theory
differential geometry: noncommutative
operator: algebra
phi**n model: 3
perturbation theory: higher-order
phi**n model: 4
charge: conservation law
topology

description: Universität Hamburg, Diplomarbeit, 2003; 88 pp., (2003). doi:10.3204/DESY-THESIS-2003-041
description: We develop a general framework for the formulation of the action principle and the Noether theorem for classical noncommutative field theories. We give a concrete example of an algebra that fits into this framework. It describes a scalar field theory on noncommutative Minkowski space. We develop a notion of locality for this algebra and investigate the locality properties of localised interaction terms. This leads us to the definition of local functionals on the field algebra. We propose a scheme for the quantisation of these functionals.
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Construct and predictive validity of the Psychopathy Checklist: screening version in a violent offender population in Australia
Creators: name: Veal, Ryan G.
Publisher: name: Swinburne
Year: 2024

description: The base rate of psychopathy is consistently reported to be considerably higher in offender populations compared to in the general community. A debate in the research literature concerning psychopathy assessment surrounds the role of antisocial behaviour within the conceptualisation of the Psychopathy Checklist instruments. This thesis is the first comprehensive evaluation of the screening version of the Psychopathy Checklist in an Australian offender sample. Results failed to support the established conceptualisation of this tool; yet results were consistent with international research for predicting reoffending. Findings have implications for the risk assessment, treatment, and management of Australian violent offenders.
Multi-messenger connection in high-energy neutrino astronomy
Creators: name: Sharma, Ankur
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Low fluxes of astrophysical neutrinos at TeV energies and the overwhelming background of atmospheric neutrinos below that, render the current paradigm of neutrino astronomy as a severely statistics limited one. While many hints have emerged, all the evidence gathered by IceCube and ANTARES, over the course of almost a decade and a half of operation, have fallen short of providing any conclusive answer to the puzzle of the origin of high-energy cosmic rays and neutrinos. The advancement of the field is thus closely associated with not only the neutrino observatories coming online in the next few years, but also on the coordinated efforts of the EM, GW and cosmic ray communities to develop dedicated channels and infrastructure that allows for swift and comprehensive multi-messenger follow-up of relevant events detected in any of the sectors. This paper highlights the strides that have been already taken in that direction and the fruits that they have born, as well as the challenges that lie ahead.
description: Review article; 19 pages; 7 figures
Job-related stress and work ability of dispatchers in a metropolitan fire department
Creators: name: Oldenburg, Marcus
name: Wilken, Dennis
name: Wegner, Ralf
name: Poschadel, Bernd
name: Baur, Xaver
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie::152 Sinneswahrnehmung, Bewegung, Emotionen, Triebe
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Our aim was to assess psychomental stress and strain among dispatchers in fire departments, particularly during emergency instructions by phone and to evaluate their work ability. Methods 27 dispatchers and 20 controls were examined. In a protocol, participants recorded 1. phone instructions causing mental stress (event) 2. working time without phone instructions (non-event) 3. breaks. Continuous heart rate (variability), urine catecholamine, salivary cortisol and lymphocytes were measured. To assess the job-related burden, the Work Ability Index (WAI) was applied. Results Dispatchers demonstrated significantly higher heart rates and reduced standard deviation of all NN (heartbeat-to-heartbeat) intervals (SDNN) than the controls in all phases. WAI of dispatchers was significantly lower than that of the controls. Within the dispatchers, there was a significantly higher rate of inability to work during the past year. Conclusions The increased heart rate and reduced SDNN of examined dispatchers indicate chronic stress effects as a possible preliminary stage of a health disorder. In respect of the reduced work ability among dispatchers preventive measures are required to reduce the stress situation during their job-performance.
3803541.pdf
Creators: name: Cortese, Erika
name: Carusotto, Iacopo
name: Colombelli, Raffaele
name: De Liberato, Simone
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document provides supplementary information to "Strong coupling of ionising transitions", including explicit derivations of the theoretical results presented in the main paper.
Insulin-mediated GLUT4 translocation via small molecule binding of UNC119B for the treatment of diabetes mellitus
Creators: name: Moore, Autumn E.
Publisher: name: University of Iowa
Year: 2024
Subjects: glucose transporter
insulin resistance
insulin sensitizer
Chemistry
public abstract
Diabetes

description: Type II diabetes (T2D) is a disease that is characterized by insulin resistance, hyperglycemia, and impaired insulin secretion via pancreatic b-cells. In skeletal muscle and adipose cells, T2D results in the dysregulation of downstream functions associated with the insulin signaling pathways. In this disease state, insulin is unable to bind receptors that trigger a signaling cascade that triggers GLUT4 in the vesicles to translocate to the surface of cells for glucose storage. Impaired GLUT4 translocation results in the accumulation of glucose in blood, resulting in hyperglycemia. Currently, treatments for diabetes have largely failed to control blood glucose levels through utilization of endogenous insulin or correct insulin insensitivity. As a result, a luciferase-based assay was developed to identify small molecules that could restore GLUT4 translocation in the presence of endogenous insulin in order to prevent hypoglycemia. In identifying small molecule mediators of insulin-dependent GLUT4 translocation, the X-ray crystal structure of small molecule insulin sensitizer bound to UNC119B was utilized to guide the design and synthesis of novel small molecule insulin sensitizers. Concurrently, multiple different structures that were predicted to bind UNC119B were evaluated in silico and identified synthetically tractable compounds from computational and docking analyses. Compounds C59 and 237 were amongst the most potent and efficacious agents that increased insulin-mediated GLUT4 translocation through binding of UNC119B. Issues arose in solubilizing the compounds in water due to both being comprised of aromatic and adamantyl moieties. To remedy this issue, phase solubility studies were conducted to identify the most compatible cyclodextrin to complex with C59 and 237. Of the 3 cyclodextrins tested (alpha, gamma, and hydroxypropyl-beta), hydroxypropyl-beta-cyclodextrin increased both C59 and 237 water solubility from <1 mM to >1 mM and >4 mM, respectively.
The High Time Resolution Universe survey - XI. Discovery of five recycled pulsars and the optical detectability of survey white dwarf companions
Creators: name: Bates, S. D.
name: Thornton, D.
name: Bailes, Matthew
name: Barr, Ewan
name: Bassa, C. G.
name: Bhat, N. D. R.
name: Burgay, M.
name: Burke-Spolaor, S.
name: Champion, D. J.
name: Flynn, Christopher
name: Jameson, A.
name: Johnston, S.
name: Keith, M. J.
name: Kramer, M.
name: Levin, L.
name: Lyne, A.
name: Milia, S.
name: Ng, C.
name: Petroff, E.
name: Possenti, A.
name: Stappers, B. W.
name: van Straten, Willem
name: Tiburzi, C.
Publisher: name: Swinburne
Year: 2024

description: We present the discovery of a further five recycled pulsar systems in the mid-Galactic latitude portion of the High Time Resolution Universe survey. The pulsars have rotational periods ranging from 2 to 66 ms, and four are in binary systems with orbital periods between 10.8 h and 9 d. Three of these binary systems are particularly interesting; PSR J1227−6208 has a pulse period of 34.5 ms and the highest mass function of all pulsars with near-circular orbits. The circular orbit suggests that the companion is not another neutron star, so future timing experiments may reveal one of the heaviest white dwarfs ever found (>1.3 M⊙). Timing observations of PSR J1431−4715 indicate that it is eclipsed by its companion which has a mass indicating it belongs to the redback class of eclipsing millisecond pulsars. PSR J1653−2054 has a companion with a minimum mass of only 0.08 M⊙, placing it among the class of pulsars with low-mass companions. Unlike the majority of such systems, however, no evidence of eclipses is seen at 1.4 GHz.
Automatic generation of virtual worlds from architectural and mechanical CAD models
Creators: name: Szepielak, Daniel
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003
Subjects: thesis
accelerator
buildings
hardware
programming: management

description: Silesian University of Technology, Masterarbeit, 2003; 72 pp., (2003). doi:10.3204/DESY-THESIS-2003-042
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Searching for gravitational wave memory bursts with the Parkes Pulsar Timing Array
Creators: name: Wang, J. B.
name: Hobbs, G.
name: Coles, W.
name: Shannon, Ryan
name: Zhu, X. J.
name: Madison, D. R.
name: Kerr, M.
name: Ravi, V.
name: Keith, M. J.
name: Manchester, R. N.
name: Levin, Y.
name: Bailes, Matthew
name: Bhat, N. D. R.
name: Burke-Spolaor, S.
name: Dai, S.
name: Oslowski, Stefan
name: van Straten, Willem
name: Toomey, L.
name: Wang, N.
name: Wen, L.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 5101
subject: Astronomical sciences
classificationCode: 5109
subject: Space sciences

description: Anisotropic bursts of gravitational radiation produced by events such as super-massive black hole mergers leave permanent imprints on space. Such gravitational wave 'memory' (GWM) signals are, in principle, detectable through pulsar timing as sudden changes in the apparent pulse frequency of a pulsar. If an array of pulsars is monitored as a GWM signal passes over the Earth, the pulsars would simultaneously appear to change pulse frequency by an amount that varies with their sky position in a quadrupolar fashion. Here we describe a search algorithm for such events and apply the algorithm to approximately six years of data from the Parkes Pulsar Timing Array. We find no GWM events and set an upper bound on the rate for events which could have been detected. We show, using simple models of black hole coalescence rates, that this non-detection is not unexpected.