cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Project for the Synopia of the Integrated City. MODEL I: Harbor-Center with Water-Sea-Earth Communication Routes
Creators: name: Cattabriga, Ilaria
Publisher: name: Histories of Postwar Architecture
Year: 2023

description: This paper wants to introduce Leonardo Ricci’s project for the integrated town identifiable on two kinds of archival series: the pictures of a three-dimensional model titled MODEL I: Harbor-center with water-sea-earth communication routes kept in Casa Studio Ricci in Florence and the bidimensional drawings kept in CSAC (Centro Studi e Archivio della Comunicazione) Archive, by framing it in his architectural work and research of the Sixties, which saw an intense exchange with the United States. It will be outlined in its fundamental aspects by explaining firstly the theoretical then the applied research Ricci dedicated to the elaboration of the model, as he maybe would have presented it according to its strong belief in the intertwining between these two layers. The final part will deal with a comparison of the analyzed project to the coeval model for the “Casa Abitata” exhibition, presented one year before in Florence. Both models show the same purposes and final similar morphological results, the first elaborated in the United States, the second one in Italy, as a consequence of Ricci’s research for a synthesis between architecture and sculpture and as a necessary melting between the physical and the social structures, thus the search for the most livable and useful spaces for the best development of modern life.
description: Histories of Postwar Architecture, No. 9 (2021): Leonardo Ricci (1918-1994). Archives I
Ethical guidance for research with a potential for human enhancement
Creators: name: Erden, Yasemin J.
name: Brey, Philip
Publisher: name: Zenodo
Year: 2021
Subjects: ethical guidance
human enhancement
research
human enhancement projects
ethical issues
ethical assessment
ethical framework
research ethics
medical ethics
Horizon Europe

description: This guidance document aims to help researchers to consider, examine, and address ethical issues associated with human enhancement. Human enhancement refers to a wide field of interventions and technologies that aim at improving human beings beyond what might otherwise be considered typical or average. The guidance in this document is designed to be cross-disciplinary, and not limited to a particular field of science, engineering or medicine. It aims to cover all fields in research and development (R&D) where human enhancement potential may occur. Although it has wider application, this document has been composed for Horizon Europe ethics review and it thereby also complements other documentation for the ethics review procedure in Horizon Europe. This document is intended for the following types of projects: (1) Projects in which human enhancement is an explicit aim, either through research intended to facilitate human enhancement applications, or through the development of products or techniques intended for human enhancement; (2) Projects that have unforeseen, unpredicted or unintended potential enhancement applications, by which is meant that research and/or development is undertaken for therapeutic or other non-enhancement purposes, but the results of the project also have a clear potential for human enhancement.
title: Patterns of 31 new autoantibodies against G-protein-coupled receptors and growth factors in systemic sclerosis can be described by latent factors
Creators: name: Bittern, Hannah
name: Carvalho-Marques, Alexandre
name: Cabral-Marques, Otavio
name: Fouodo, Cesaire Joris Kuete
name: König, Inke
name: Heidecke, Harald
name: Riemekasten, Gabriela
name: Schinke, Susanne
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Systemic sclerosis (SSc) is a rare autoimmune multisystemic disease with a significant disease burden and impact on life quality and survival. Disease specific, diagnostic and prognostic antibodies (ab) are known such as Scl70 and centromer (ACA) ab [1] or recently endothelin or[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Changes in Statin Adherence Following an Acute Myocardial Infarction Among Older Adults: Patient Predictors and the Association With Follow‐Up With Primary Care Providers and/or Cardiologists
Creators: name: Fang, Gang
name: Cole, Ashley L.
name: Hickson, Ryan P.
name: Korhonen, Maarit Jaana
name: Robinson, Jennifer G.
name: Annis, Izabela E.
name: Killeya-Jones, Ley A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Hospitalizations for acute myocardial infarctions (AMIs) are associated with changes in statin adherence. It is unclear to what extent adherence changes, which patients are likely to change, and how post-discharge follow-up is associated with statin adherence change.

METHODS AND RESULTS: This retrospective study used Medicare data for all fee-for-service beneficiaries 66 years and older with an AMI hospitalization in 2008-2010 and statin use before their index AMI. Multivariable multinomial logistic regression models (odds ratio [OR] and 99% confidence interval [CI]) were applied to assess associations between both patient characteristics and follow-up with a primary care provider and/or cardiologist with the outcome of statin adherence change (increase or decrease) from the 6-month pre- to 6-month post-AMI periods. Of 113 296 patients, 64.0% had no change in adherence, while 19.7% had increased and 16.3% had decreased adherence after AMI hospitalization. Black and Hispanic patients were more likely to have either increased or decreased adherence than white patients. Patients who required coronary artery bypass graft surgery (OR, 1.34; 99% CI, 1.21-1.49) or percutaneous transluminal coronary angioplasty/stent procedure (OR, 1.25; 99% CI, 1.17-1.32) during their index hospitalization were more likely to have increased adherence. Follow-up with a primary care provider was only mildly associated with increased adherence (OR, 1.08; 99% CI, 1.00-1.16), while follow-up with a cardiologist (OR, 1.15; 99% CI, 1.05-1.25) or both provider types (OR, 1.21; 99% CI, 1.12-1.30) had stronger associations with increased adherence.

CONCLUSIONS: Post-AMI changes in statin adherence varied by patient characteristics, and improved adherence was associated with post-discharge follow-up care, particularly with a cardiologist or both a primary care provider and a cardiologist.
Towards the Macrostructure. Leonardo Ricci’s Ideas for the Unbuilt Pleydell Bouverie House (1958-1960)
Creators: name: Conforti, Beatrice
Publisher: name: Histories of Postwar Architecture
Year: 2023

description: The essay tries to make more widely known the project of the Pleydell Bouverie House, which was designed by Leonardo Ricci in 1958-60 but never built. In addition, to describe the drawings, many of which have been put in a new light thanks to the Centenary of the architect’s death, the text attempts to use the description of two other realized works to highlight certain characteristics. This is also supported by some three-dimensional diagrams produced during the analysis of the project. These diagrams are part of a wider research carried out by the author of the essay within the dissertation The density of space. Forms of living in the work of Leonardo Ricci at the Department of Architecture Theories and Design of La Sapienza University of Rome. The assumption is that, through this house in particular, Ricci tested architectural elements and strategies aimed at the realization of the macrostructure. A comparison is made with the Cardon House in Castiglioncello and, at the same time, with the building La Nave in the Sorgane district, in Florence. We find this approach interesting in order to imagine both the origins of certain ideas and what the results of the realization of Pleydell Bouverie House might have been. The present paper, therefore, tries to provide not only a description of a single-family house that Ricci never built, but to contribute with a precise observation of certain aspects, aimed at placing this work in the broader discussion of Leonardo Ricci’s approach and vision about architecture.
description: Histories of Postwar Architecture, No. 9 (2021): Leonardo Ricci (1918-1994). Archives I
Additional file 1 of Barriers and facilitators to the utilization of the intensive adherence counselling framework by healthcare providers in Uganda: a qualitative study
Creators: name: Musinguzi, Pius
name: Najjuma, Josephine Nambi
name: Arishaba, Adellah
name: Ochen, Eric
name: Ainembabazi, Racheal
name: Keizirege, Fred
name: Sabano, Racheal Lillian
name: Wakida, Edith K.
name: Obua, Celestino
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 1.
title: Pathophysiological role of type I and III interferons in systemic lupus erythematosus (SLE)
Creators: name: Meineck, Myriam
name: Kommer, Andreas
name: Saurin, Sabrina
name: Pautz, Andrea
name: Schwarting, Andreas
name: Weinmann-Menke, Julia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Systemic Lupus erythematosus (SLE) is an autoimmune disease characterized by activated autoreactive lymphocytes and autoantibody production, resulting in tissue damage in multiple organs. A frequent observed severe manifestation is Lupus nephritis (LN), possibly resulting in limited kidney[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Mercato dei Fiori in Pescia (1948-1951): Design Inventiveness and Constructional Experimentation in Italy after the Second World War
Creators: name: Antonucci, Micaela
name: Fantoni, Alice
Publisher: name: Histories of Postwar Architecture
Year: 2023

description: After the Second World War, Italy shifted within a few years from post-war reconstruction to the economic “boom”, attracting international attention with a series of highly original works and extraordinary examples of structural and constructional experimentation despite a strong technological delay compared to other industrialised countries. In the immediate aftermath of the war, projects in which formal invention was closely linked to innovation in materials and structures developed all over Italy, creating a “built catalogue” of experimental techniques. Brick was among the materials that were widely available and deeply rooted in the traditional building. Indeed, the development of the so-called “reinforced brick” in the interwar period had paved the way to the construction of thin, light structures that could be built saving time and costs. One of the first and most significant Italian experiments with this material was the Mercato dei Fiori (Flowers Market) in Pescia, Tuscany. It was the work of a team composed of architects Giuseppe Giorgio Gori, Leonardo Ricci, Leonardo Savioli, and Enzo Gori, along with the engineer Emilio Brizzi. The presence of four architects and one engineer in the group meant that the two aspects of the project – design and construction – were both thoroughly studied and intimately connected. This was the key to the successful combination of structural boldness and formal originality that made this building a case study in post-war Italian architecture and also earned it international fame. This structure still remains an important testimony to a formidable period of constructional experimentation in post-war Italy; the analyses of its material and structural aspects, which have not been considered so far by scholarly studies on either the building or its authors, represent fundamental investigative tools for fully understanding its value and innovation. The paper proposes an analysis of the Market’s space and compositional principles relying upon a deep understanding of its structural conception, since the simplicity and lightness of the final result were only possible thanks to the innovative adoption of technological solutions that were widely known but still used infrequently or in different settings.
description: Histories of Postwar Architecture, No. 9 (2021): Leonardo Ricci (1918-1994). Archives I
A THEORETICAL ANALYSIS OF NEW HRM CHALLENGES IN 21ST CENTURY
Creators: name: Mrs.R.Umadevi1   Mr.N.Thiagarajan2
Publisher: name: Zenodo
Year: 2022
Subjects: Globalization, Strategic Partner, Technological Advancement, Dynamic Environment, Change Management.

description: Abstract Two decades ago, the globe transitioned from traditional to strategic HRM, the emphasis of HR practises also changed from merely assuring financial advantages to ensuring an increase in personal value and the welfare of the employees. The advent of the New Ways of Working (NWOW), wherein employees are no longer compelled to abide by the time and space constraints of the workspace, has fundamentally changed how HR responsibilities are carried out. Organizational psychology provided the foundation for the human resource management discipline, which has since emerged as a crucial management tool. With time, this practice's strategic role started to take shape. HR managers now have a difficult job because HR has developed into a crucial strategic partner in a firm. Human resource management departments are now essential to running modern firms in the twenty-first century. This article focuses in particular on how human resource management practises have changed in the twenty-first century. The purpose of this theoretical essay is to emphasise the significance of human resource management, HR practises, and the factors that influence them. In addition, this article describes the forthcoming difficulties that HR managers will have in the twenty-first century. The purpose of the literature analysis was to illustrate contemporary practises, difficulties, and developing topics in the field of human resource management.
Impact of Regional Systems of Care on Disparities in Care Among Female and Black Patients Presenting With ST‐Segment–Elevation Myocardial Infarction
Creators: name: Al-Khalidi, Hussein R.
name: Monk, Lisa
name: Granger, Christopher B.
name: Tamis-Holland, Jacqueline E.
name: Wilson, B. Hadley
name: Jollis, James G.
name: Corbett, Claire C.
name: Roettig, Mayme L.
name: Berger, Peter B.
name: Fordyce, Christopher B.
name: Sherwood, Matthew W.
name: Gu, Xiangqiong
name: Hinohara, Tomoya T.
name: Burchenal,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: The American Heart Association Mission: Lifeline STEMI (ST-segment-elevation myocardial infarction) Systems Accelerator program, conducted in 16 regions across the United States to improve key care processes, resulted in more patients being treated within national guideline goals (time from first medical contact to device: <90 minutes for direct presenters to hospitals capable of performing percutaneous coronary intervention; <120 minutes for transfers). We examined whether the effort reduced reperfusion disparities in the proportions of female versus male and black versus white patients.

METHODS AND RESULTS: In total, 23 809 patients (29.3% female, 82.3% white, and 10.7% black) presented with acute STEMI between July 2012 and March 2014. Change in the proportion of patients treated within guideline goals was compared between sex and race subgroups for patients presenting directly to hospitals capable of performing percutaneous coronary intervention (n=18 267) and patients requiring transfer (n=5542). The intervention was associated with an increase in the proportion of men treated within guideline goals that presented directly (58.7-62.1%, P=0.01) or were transferred (43.3-50.7%, P<0.01). An increase was also seen among white patients who presented directly (57.7-59.9%, P=0.02) or were transferred (43.9-48.8%, P<0.01). There was no change in the proportion of female or black patients treated within guideline goals, including both those presenting directly and transferred.

CONCLUSION: The STEMI Systems Accelerator project was associated with an increase in the proportion of patients meeting guideline reperfusion targets for male and white patients but not for female or black patients. Efforts to organize systems of STEMI care should implement additional processes targeting barriers to timely reperfusion among female and black patients.
Decoherence in current induced forces: Application to adiabatic quantum motors
Creators: name: Fernández-Alcázar, Lucas J.
name: Bustos-Marún, Raúl A.
name: Pastawski, Horacio M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Current induced forces are not only related with the discrete nature of electrons but also with its quantum character. It is natural then to wonder about the effect of decoherence. Here, we develop the theory of current induced forces including dephasing processes and we apply it to study adiabatic quantum motors (AQMs). The theory is based on Büttiker's fictitious probe model which here is reformulated for this particular case. We prove that it accomplishes fluctuation-dissipation theorem. We also show that, in spite of decoherence, the total work performed by the current induced forces remains equal to the pumped charge per cycle times the voltage. We find that decoherence affects not only the current induced forces of the system but also its intrinsic friction and noise, modifying in a non trivial way the efficiency of AQMs. We apply the theory to study an AQM inspired by a classical peristaltic pump where we surprisingly find that decoherence can play a crucial role by triggering its operation. Our results can help to understand how environmentally induced dephasing affects the quantum behavior of nano-mechanical devices.
title: Auftreten des Makrophagenaktivierungssyndroms unter Therapie mit Biologika – aktuelle Daten aus dem BIKER Register
Creators: name: Hospach, Anton
name: Conzelmann, Dennis
name: Horneff, Gerd
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Das Makrophagenaktivierungssyndrom (MAS) ist eine lebensbedrohliche Komplikation der systemischen juvenilen Arthritis (sJIA). Wenngleich bis zu 15% daran erkranken, sind die publizierten Fallzahlen gering. Die ursprüngliche Annahme einer „Mitbehandlung“ des MAS im[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Histories of Postwar Architecture, No. 9 (2021): Leonardo Ricci (1918-1994). Archives I
title: Leonardo Ricci (1918-1994). Archives I
titleType: AlternativeTitle
Creators: name: Histories Of Postwar Architecture
Publisher: name: Histories of Postwar Architecture
Year: 2023

description: New Research on Leonardo Ricci’s Archives...4-9 The Bourgeois in Revolt against Themselves. Cultural Revolution in the U. S....57-64 “A Sculpture that Allows a Journey through Expressionism”: a Reply to Nello Ponente...91-94 Architecture in Relationship to the Other Arts...97-110 “My life as an architect is but an episode of my inner life, an ordinary act like so many acts make up our day”: a Letter to Tullio Vinay...13-16 Hon. Pleydell Bouverie House...43-44 Staging of the Costume Sector in the Italian Pavilion of Expo 67...138-140 Flowers Market of Pescia...17-18 Dei Leggieri Theatre...87-88 “Orfeo” Scenographies and Dressing...95-96 F. D. Roosevelt Memorial...55-56 Savona Palace of Justice...244-247 Macrostructure for an Integrated Town...111-113 Goti Factory...65-67 Staging of “Espressionismo: pittura scultura architettura”...89-90 Directional Center of Florence...217-219 Fausto Maria Ricci House...36-37 Arnaldo Ricci House...38-40 Balmain House...41-42 Ecumenical Village of Agàpe...10-12 Leonardo Ricci and the Project for the “Man-Machine Space”: the Goti Factory (1959)...68-86 Erratum: The Urban Imaginary in Doha, Qatar...258 Staging of the Costume Sector in the Italian Pavilion of Expo 67 in Montréal, Canada (1966-1967). From “Urschrei” to “Correalism”. Considerations on Some Motifs in Leonardo Ricci (1962-1967)...141-216 Too Good to Be True: the Savona Courthouse...248-257 Leonardo Ricci’s Palace of Justice in Florence. A Desolate Fragment of an Urban Ideal (1987-1994)...220-243 A Project for the Synopia of the Integrated City. MODEL I: Harbor-Center with Water-Sea-Earth Communication Routes...114-137 Towards the Macrostructure. Leonardo Ricci’s Ideas for the Unbuilt Pleydell Bouverie House (1958-1960)...45-54 Mercato dei Fiori in Pescia (1948-1951): Design Inventiveness and Constructional Experimentation in Italy after the Second World War ...19-35
Canopy bridges: Preventing and mitigating anthropogenic impacts on mantled howler monkeys in Costa Rica
Creators: name: Rojas, Inés Azofeifa
name: Gregory, Tremaine
Publisher: name: Brill Online
Year: 2022
Subjects: Ecology not elsewhere classified

description: Increasing levels of anthropogenic modification, degradation, and fragmentation of arboreal mammal habitats substantially influence wildlife movement and behavior. In Costa Rica, there has been a surge in infrastructure development in the past decade. This infrastructure puts wildlife at high risk of mortality from electrocution, vehicle collisions, falls, and attacks by domestic animals. To prevent and mitigate the mortality of arboreal animals, canopy bridges have been implemented in several parts of the country. In Playa Hermosa, Guanacaste, a coastal community, we implemented a canopy bridge project for mantled howler monkeys (Alouatta palliata). For the first year of our study (2015–2016), we performed monthly three-day censuses and follows of all howler monkey groups. After the first five months of data collection, we identified 20 high-use arboreal pathways that would benefit from reinforcement with canopy bridges and installed camera traps in the pathways to verify their use outside of sampling periods. After use was verified, we installed canopy bridges at those 20 sites. We continued to identify high-use paths via group follows, ad libitum sightings from community members, and annual group censuses between 2018 and 2021 and installed an additional 91 bridges (N = 111 total). We also developed a system for community reporting of howler monkey injuries and fatalities and advocated for better insulation of electric cables, with 8,341 m insulated between 2015 and 2021. Between 2015 and 2021, we saw the number of monkey groups grow from five to seven, group home ranges grow, the population grow from 59 to 99, and fatalities decrease from five to one annually. We conclude that the bridges likely contribute to howler monkey population growth via decreased fatalities and safer access to feeding resources and mates. Costa Rica is currently adopting legislation to make connectivity mitigation measures for wildlife mandatory in infrastructure development, making it a global leader.
Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition
Creators: name: Parry, Traci L.
name: Huang, Wei
name: Jensen, Brian C.
name: Beak, Ju Youn
name: Stuhlmiller, Timothy J.
name: Chen, Xin
name: Hicks, Sean T.
name: Sciaky, Noah
name: Willis, Monte S.
name: Zawistowski, Jon S.
name: Angus, Steven P.
name: Johnson, Gary L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Most novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe. The basis for this distinction is unclear, as are the molecular effects of kinase inhibitors in the heart.

METHODS AND RESULTS: We administered clinically relevant doses of sorafenib, sunitinib (cardiotoxic multitargeted kinase inhibitors), or erlotinib (a cardiosafe epidermal growth factor receptor inhibitor) to mice daily for 2 weeks. We then compared the effects of these 3 kinase inhibitors on the cardiac transcriptome using RNAseq and the cardiac kinome using multiplexed inhibitor beads coupled with mass spectrometry. We found unexpectedly broad molecular effects of all 3 kinase inhibitors, suggesting that target kinase selectivity does not define either the molecular response or the potential for cardiotoxicity. Using in vivo drug administration and primary cardiomyocyte culture, we also show that the cardiosafety of erlotinib treatment may result from upregulation of the cardioprotective signal transducer and activator of transcription 3 pathway, as co-treatment with erlotinib and a signal transducer and activator of transcription inhibitor decreases cardiac contractile function and cardiomyocyte fatty acid oxidation.

CONCLUSIONS: Collectively our findings indicate that preclinical kinome and transcriptome profiling may predict the cardiotoxicity of novel kinase inhibitors, and suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription/epidermal growth factor receptor inhibition for cancer treatment.
Additional file 1 of Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Creators: name: Vallejo, Jenifer
name: Saigusa, Ryosuke
name: Gulati, Rishab
name: Armstrong Suthahar, Sujit Silas
name: Suryawanshi, Vasantika
name: Alimadadi, Ahmad
name: Durant, Christopher P.
name: Ghosheh, Yanal
name: Roy, Payel
name: Ehinger, Erik
name: Pattarabanjird, Tanyaporn
name: Hanna, David B.
name: Landay, Alan L.
name: Tracy, Russell P.
name: Lazar, Jason M.
name: Mack, Wendy J.
name: Weber, Kathleen M.
name: Adimora, Adaora A.
name: Hodis, Howard N.
name: Tien, Phyllis C.
name: Ofotokun, Igho
name: Heath, Sonya L.
name: Shemesh, Avishai
name: McNamara, Coleen A.
name: Lanier, Lewis L.
name: Hedrick, Catherine C.
name: Kaplan, Robert C.
name: Ley, Klaus
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Supplementary Figures and Tables. Figure S1. (Related to Figure 1). Design of the study comparison between study participants. Figure S2. (Related to Figure 1). (A) Ridgeline plots of the unthresholded expressions of all the 40 surface markers for each main cell types. (B) Age projection (below and above median) onto CM, INT, NCM, CD4+ T cells and CD8+ T cell UMAPs. Figure S3. (Related to Figure 5). Dotplots of DEG for disease types for subsets. Table S1. Reagents. Table S2. The cell viability of each frozen PBMC tube. Table S3. List of 40 titrated oligonucleotide-tagged monoclonal antibodies. Table S4. List of selected genes included in the custom panel. Table S5. Threshold values of each antibody. Table S6. Antibodies not used for cell clustering. Table S7. Number of Cells in each of the clusters. Table S8. Significantly differentially expressed genes for each cell type (A-E). Table S9. Number of Cells for each participant. Table S10. Non-negative Spearman correlation between antibody and gene in each cell type.
Classroom experiments: Testing the asymmetric convergence in a new framing (firm-worker instead of buyer-seller)
Creators: name: Nax
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: asymmetric convergence
subject: competitive equilibrium
subject: experiment
subject: micro
subject: non-durables

description: This is another robustness check. Instead of focusing on the DA, we now change the framing of classical OTC (a la Chamberlin, JPE, 1948) trading experiments from the usual buyer-seller frame to an employer-employee frame. Roberto Weber from UZH conjectured during a seminar at UZH in 2022 that this might neutralize or reverse the kind of asymmetry of convergence that we previously found (see Ikica et al., 2023, IER). This project flanks the registration "Testing the asymmetric convergence in a new framing (firm-worker instead of buyer-seller)" of the corresponding DA analysis, which we shall pursue as a controlled online experiment.
Production cross section estimates for strongly-interacting Electroweak Symmetry Breaking Sector resonances at particle colliders
Creators: name: Dobado, Antonio
name: Guo, Feng-Kun
name: Llanes-Estrada, Felipe J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We are exploring a generic strongly-interacting Electroweak Symmetry Breaking Sector (EWSBS) with the low-energy effectie field theory for the four experimentally known particles ($W_L^\pm$, $Z_L$, $h$) and its dispersion-relation based unitary extension. In this contribution we provide simple estimates for the production cross section of pairs of the EWSBS bosons and their resonances at proton-proton colliders as well as in a future $e^-e^+$ (or potentially a $μ^-μ^+$) collider with a typical few-TeV energy. We examine the simplest production mechanisms, tree-level production through a $W$ (dominant when quantum numbers allow) and the simple effective boson approximation (in which the electroweak bosons are considered as collinear partons of the colliding fermions). We exemplify with custodial isovector and isotensor resonances at 2 TeV, the energy currently being discussed because of a slight excess in the ATLAS 2-jet data. We find it hard, though not unthinkable, to ascribe this excess to one of these $W_LW_L$ rescattering resonances. An isovector resonance could be produced at a rate smaller than, but close to earlier CMS exclusion bounds, depending on the parameters of the effective theory. The $ZZ$ excess is then problematic and requires additional physics (such as an additional scalar resonance). The isotensor one (that would describe all charge combinations) has a smaller cross section.
description: 15 pages, 8 figures
Two Transiting Earth-size Planets Near Resonance Orbiting a Nearby Cool Star
Creators: name: Petigura, Erik A.
name: Schlieder, Joshua E.
name: Crossfield, Ian J. M.
name: Howard, Andrew W.
name: Deck, Katherine M.
name: Ciardi, David R.
name: Sinukoff, Evan
name: Allers, Katelyn N.
name: Best, William M. J.
name: Liu, Michael C.
name: Beichman, Charles A.
name: Isaacson, Howard
name: Hansen, Brad M. S.
name: Lépine, Sébastien
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Discoveries from the prime Kepler mission demonstrated that small planets (< 3 Earth-radii) are common outcomes of planet formation. While Kepler detected many such planets, all but a handful orbit faint, distant stars and are not amenable to precise follow up measurements. Here, we report the discovery of two small planets transiting K2-21, a bright (K = 9.4) M0 dwarf located 65$\pm$6 pc from Earth. We detected the transiting planets in photometry collected during Campaign 3 of NASA's K2 mission. Analysis of transit light curves reveals that the planets have small radii compared to their host star, 2.60 $\pm$ 0.14% and 3.15 $\pm$ 0.20%, respectively. We obtained follow up NIR spectroscopy of K2-21 to constrain host star properties, which imply planet sizes of 1.59 $\pm$ 0.43 Earth-radii and 1.92 $\pm$ 0.53 Earth-radii, respectively, straddling the boundary between high-density, rocky planets and low-density planets with thick gaseous envelopes. The planets have orbital periods of 9.32414 days and 15.50120 days, respectively, and have a period ratio of 1.6624, very near to the 5:3 mean motion resonance, which may be a record of the system's formation history. Transit timing variations (TTVs) due to gravitational interactions between the planets may be detectable using ground-based telescopes. Finally, this system offers a convenient laboratory for studying the bulk composition and atmospheric properties of small planets with low equilibrium temperatures.
description: Updated to ApJ accepted version; photometry available alongside LaTeX source; 10 pages, 7 figures
Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community
Creators: name: Wu, Aozhou
name: Tanaka, Hirofumi
name: Heiss, Gerardo
name: Selvin, Elizabeth
name: Matsushita, Kunihiro
name: Coresh, Josef
name: Hirsch, Alan T.
name: Jaar, Bernard G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Evidence regarding the association of lower extremity peripheral arterial disease with quality of life (QOL) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community-derived populations.

METHODS AND RESULTS: Using data of 5115 participants aged 66 to 90 years from visit 5 (2011-2013) of the Atherosclerosis Risk in Communities Study, we quantified the associations of ankle-brachial index (ABI) with several QOL parameters, including 12-item Short-Form Health Survey (SF-12), after accounting for potential confounders using linear and logistic regression models. Peripheral arterial disease defined by an ABI <0.90 (n=402), was independently associated with a low SF-12 Physical Component Summary score (-3.26 [95% CI -5.60 to -0.92]), compared to the ABI reference 1.10 to 1.19 (n=1900) but not with the Mental Component Summary score (-0.07 [-2.21 to 2.06]). A low ABI was significantly associated with poorer status of all SF-12 physical domains (physical functioning, role-physical, bodily pain, and general health) but only vitality out of 4 mental domains. Similarly, low ABI values were more consistently associated with other physically related QOL parameters (leisure-time exercise/activity/walking) than mentally related parameters (significant depressive symptoms and hopeless feeling). Lower physical QOL was observed even in individuals with borderline low ABI (0.90 to 0.99; n=426).

CONCLUSIONS: Low ABI (even borderline) was independently associated with poor QOL, especially for physical components, in community-dwelling older adults. QOL is a critical element for older adults, and thus, further studies are warranted to assess whether peripheral arterial disease-specific management can improve QOL in older populations.
Objectively Measured Sedentary Time and Cardiovascular Risk Factor Control in US Hispanics/Latinos With Diabetes Mellitus: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Creators: name: Hua, Simin
name: Mossavar-Rahmani, Yasmin
name: Wang, Tao
name: Wang, Xueyin
name: Gellman, Marc D.
name: Qi, Qibin
name: Sotres-Alvarez, Daniela
name: O'Brien, Matthew J.
name: Larissa Avilés-Santa,
name: Buelna, Christina
name: Gallo, Linda C.
name: Stoutenberg, Mark
name: Kaplan, Robert C.
name: Strizich, Garrett
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate-to-vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus.

METHODS AND RESULTS: This cross-sectional analysis included 1699 participants with diabetes mellitus from the Hispanic Community Health Study/Study of Latinos (2008-2011). Logistic regression models were used to estimate the odds ratios (ORs) of meeting the following 5 major CVD risk factor control goals: hemoglobin A1c <7.0%; systolic/diastolic blood pressure <140/80 mm Hg; triglycerides <150 mg/dL; low-density lipoprotein cholesterol <100 mg/dL; and high-density lipoprotein cholesterol >40/50 mg/dL for men/women. After adjustment for covariates including moderate-to-vigorous physical activity, less sedentary time was associated with increased odds of reaching hemoglobin A1c (OR=1.76 [95% CI: 1.10, 2.82]) and triglyceride control goals (OR=2.16 [1.36, 3.46]), and reaching ≥3 CVD risk factor control goals (OR=2.08 [1.34, 3.23]) (all ORs for comparisons of extreme tertiles of sedentary time). Moderate-to-vigorous physical activity was not associated with reaching any CVD risk factor control goals. Substituting 60-min/day of sedentary time with light-intensity physical activity was associated with increased odds of reaching hemoglobin A1c (OR=1.18 [1.04, 1.35]), high-density lipoprotein cholesterol (OR=1.17 [1.04, 1.32]), and triglyceride (OR=1.20 [1.05, 1.36]) control goals.

CONCLUSIONS: Among US Hispanic/Latino adults with diabetes mellitus, less sedentary time, but not moderate-to-vigorous physical activity, was associated with improved CVD risk factor control, specifically in reaching hemoglobin A1c and triglyceride control goals.
THE EFFECT OF PLYOMETRIC TRAINING ON EXPLOSIVE STRENGTH VARIABLE OF INTER COLLEGIATE CANOE-KAYAKING PLAYERS
Creators: name: Prof. Dr. Dnyaneshwer S. Gadakh
Publisher: name: Zenodo
Year: 2022
Subjects: Plyometric training, Explosive strength and Canoe-kayakers.

description: Abstract: The present study was an experimental research which was conducted with purpose to examine effect of plyometric training on explosive strength of Inter collegiate Canoe-kayaking players. True experimental pre-test and post-test equivalent group design was used for this study to check the hypothesis. The sample of this study was Nashik zone team selected intercollegiate male n=20 Canoe-kayaking players (10 each experimental and control groups) between the age group of 18-24 years selected through simple random sampling technique from Nashik district. Independent variable is plyometric training program and dependent variable is explosive strength. The selected subjects were pre-tested by Vertical jump, Leg strength dynamometer and 50 m Dash tests and eight weeks Plyometric training program was manipulated only on experimental group not control group. After training programs implemented experimental group’s i.e, experimental and control groups were post tested for data collection. After data collection, data of pre-test and post-test of both the groups i.e. experimental and control group, compared by independent sample t-test and interpretations were drawn. Result of the study effects of plyometric training program on was significantly effective to the vertical jump, 50 meter dash & leg strength dynamometer tests for Canoe-kayakers which indicate significant improvement of experimental group compare to the control group.
Additional file 1 of l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study
Creators: name: Zhao, Jie V.
name: Burgess, Stephen
name: Fan, Bohan
name: Schooling, C. Mary
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Summary of genome-wide association studies included in this study. Table S2. Genetic predictors for l-carnitine and acetyl-carnitine. Table S3. Associations of genetic predictors for l-carnitine and acetyl-carnitine with potential confounders. Table S4. Heterogeneity statistics for overall and sex-specific analyses on genetically predicted l-carnitine and cardiovascular disease and its risk factors. Table S5. Outliers detected in MR-PRESSO for overall and sex-specific associations of genetically predicted l-carnitine with CVD and CVD risk factors. Table S6. Power calculation for the associations of genetically predicted l-carnitine and acetyl-carnitine with cardiovascular disease and its risk factors.
Probabilistic Object Tracking using a Range Camera
Creators: name: Wüthrich, Manuel
name: Pastor, Peter
name: Kalakrishnan, Mrinal
name: Bohg, Jeannette
name: Schaal, Stefan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: We address the problem of tracking the 6-DoF pose of an object while it is being manipulated by a human or a robot. We use a dynamic Bayesian network to perform inference and compute a posterior distribution over the current object pose. Depending on whether a robot or a human manipulates the object, we employ a process model with or without knowledge of control inputs. Observations are obtained from a range camera. As opposed to previous object tracking methods, we explicitly model self-occlusions and occlusions from the environment, e.g, the human or robotic hand. This leads to a strongly non-linear observation model and additional dependencies in the Bayesian network. We employ a Rao-Blackwellised particle filter to compute an estimate of the object pose at every time step. In a set of experiments, we demonstrate the ability of our method to accurately and robustly track the object pose in real-time while it is being manipulated by a human or a robot.
Peripheral Artery Disease Prevalence and Incidence Estimated From Both Outpatient and Inpatient Settings Among Medicare Fee‐for‐Service Beneficiaries in the Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Wruck, Lisa
name: Kalbaugh, Corey A.
name: Selvin, Elizabeth
name: Bengtson, Lindsay G.S.
name: Lund, Jennifer L.
name: Heiss, Gerardo
name: Kucharska-Newton, Anna
name: Matsushita, Kunihiro
name: Loehr, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Outpatient ascertainment of peripheral artery disease (PAD) is rarely considered in the measurement of PAD clinical burden; therefore, the clinical burden of PAD likely has been underestimated while contributing to a decreased awareness of PAD in comparison to other circulatory system disorders.

METHODS AND RESULTS: The purpose of this study was to estimate the age-standardized annual period prevalence and incidence of PAD in the outpatient and inpatient settings using data from the Atherosclerosis Risk in Communities (ARIC) study linked with Centers for Medicare and Medicaid Services claims. The majority (>70%) of all PAD encounters occurred in the outpatient setting. The weighted mean age-standardized prevalence and incidence of outpatient PAD was 11.8% (95% CI 11.5-12.1) and 22.4 per 1000 person-years (95% CI 20.8-24.0), respectively. Black patients had higher weighted mean age-standardized prevalence (15.6%; 95% CI 14.6-16.4) compared with white patients (11.4%; 95% CI 11.1-11.7). Black women had the highest weighted mean age-standardized prevalence (16.9%; 95% CI 16.0-17.8). Black patients also had a higher incidence rate of PAD (31.3 per 1000 person-years; 95% CI 27.3-35.4) compared with white patients (25.4 per 1000 person-years; 95% CI 23.5-27.3). PAD prevalence and incidence did not differ by sex alone.

CONCLUSIONS: This study provides comprehensive estimates of PAD in the inpatient and outpatient settings where the majority of PAD burden was found. PAD is an important circulatory system disorder similar in prevalence to stroke and coronary heart disease.
Insights into benthic macroinvertebrate ecology in the northern Bering and southern Chukchi Seas from stable isotope analysis
Creators: name: Green, Emma Mackenzie
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Environmental science
subject: Biology
subject: Biogeochemistry
subject: benthic macroinvertebrates
subject: ecology
subject: food web
subject: Pacific Arctic
subject: stable isotope analysis

description: In the Pacific Arctic Region, the northern Bering Sea and southern Chukchi Sea support large and diverse communities of benthic macroinvertebrates that provide an important link to the pelagic communities and marine mammals that rely on the benthic populations for food. While the abundance and biomass of these benthic macroinvertebrates are well documented, little is known about how benthic macroinvertebrates interact with each other and how these interactions are affected by climate change. I measured the stable isotope composition (bulk δ15N and δ13C values) of similar species collected in 2014, 2016, 2017, and 2021 in the northern Bering and southern Chukchi Seas. Although there was little change over time in either δ15N or δ13C values, both stable isotope ratios were significantly different between stations with differing production phenologies. The southern Chukchi Sea (a productive set of sites with high chlorophyll concentrations throughout the summer) had lower δ15N values and higher δ13C values, while the northern Bering Sea site with production mostly associated with the period of sea ice breakup had higher δ15N values and lower δ13C values. This pattern was observed across similar species and feeding types. The higher δ15N values in the northern Bering Sea could be due to an extra step in the food chain from bacterial reworking. The contrast between these two regions in δ13C might indicate higher primary production in the southern Chukchi Sea compared to the northern Bering Sea. The differing food web dynamics between these two sites highlight the benthic diversity across small scales and similar organisms in Pacific Arctic food webs.
Additional file 2 of l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study
Creators: name: Zhao, Jie V.
name: Burgess, Stephen
name: Fan, Bohan
name: Schooling, C. Mary
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Fig. S1. Flow chart of the data sources in the study. Fig. S2. Sensitivity analysis on genetically predicted l-carnitine and cardiovascular disease using different analytic methods. Fig. S3. Sensitivity analysis on genetically predicted l-carnitine and cardiovascular disease by sex using different analytic methods. Fig. S4. Genetically predicted acetyl-carnitine and cardiovascular disease overall. Fig. S5. Genetically predicted acetyl-carnitine and cardiovascular disease by sex. Fig. S6. Sensitivity analysis on genetically predicted l-carnitine and CVD risk factors overall using different analytic methods. Fig. S7. Genetically predicted acetyl-carnitine and cardiovascular disease overall. Fig. S8. Sensitivity analysis on genetically predicted l-carnitine and CVD risk factors by sex using different analytic methods. Fig. S9. Genetically predicted acetyl-carnitine and cardiovascular risk factors by sex.