cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pre-Clinical Assessment of the Proteasomal Inhibitor Bortezomib as a Generalized Therapeutic Approach for Recessively Inherited Disorders
Creators: name: Jary, Calvin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: rare diseases
bortezomib
recessive disorders
velcade
drug repurposing
proteasome inhibitor

description: The number of known monogenic rare diseases (~7000) exceeds the number of effective treatments (~500) by more than an order of magnitude underlining the pressing need for generalizable therapeutic approaches for this class of conditions. In this regard, the majority of recessive and x-linked recessive disorders are caused by missense mutations encoding proteins that frequently have residual function but are rapidly degraded by the 26S proteasome. Bortezomib is a small molecule that inhibits the 26S proteasome and has been approved for use in patients for an unrelated condition; multiple myeloma. Previous work has shown that, for a small number of disorders, bortezomib can inhibit the degradation of the mutant protein, thereby increasing the protein level and activity, holding out the promise of a beneficial therapeutic effect by the repurposing of this agent. We present here a high level western blot based survey of nine recessive disorders to characterize the general effectiveness of such an approach. Thirteen patient fibroblast cell lines comprising 9 different diseases with 19 known mutations were selected on the basis of missense mutations protein expression data when available. The cell lines were incubated with bortezomib (10 nM and 50 nM; 24 hrs) and levels of the mutated protein were quantified by western blot. Unfortunately, no consistent, appreciable increase was observed for any of the conditions tested. The general therapeutic value of re-purposing bortezomib for recessive and x-linked diseases appears limited at best. The few reported cases of bortezomib successfully working in increasing mutated protein levels appear to be the exceptions and not the norm. Moreover successes are more often limited to cell lines carrying a transgene expressing the mutated protein rather than endogenous mutated protein in patient cell lines.
Supply Chain Discovery Services in an Internet of Things Environment
Creators: name: Dahbi, Abdelmounaim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Discovery Services
EPCglobal Network
Internet of Things
Supply Chain

description: Electronic Product Code (EPC) refers to a numbering standard developed to uniquely identify physical objects, loads, locations, assets and other entities which are to be tracked or otherwise identified. The tracking technology consists of assigning Radio Frequency Identification (RFID) tags, holding universally unique EPC codes, to the entities to be identified. While the EPC-RFID technology is used to identify and capture data about the physical objects to be tracked in a supply chain, the EPCglobal Network ensures the exchange of the captured data between supply chain stakeholders. Such a real-time data exchange increases visibility and efficiency throughout the supply chain, and thus it increases both company profitability and customer satisfaction. The EPCglobal Network can be regarded as the backbone for the future Internet of Things (IoT). We focus our work in this thesis on Discovery Services (DS); a suite of network lookup services enabling users to retrieve all relevant information sources with regards to a given EPC. They can be viewed as search engines for the future business infrastructure deployed in the IoT. Motivated by the unprecedented and incessantly growing amount of EPC data, the expected epidemic growth in the solicitation frequency of the lookup service, and also the foreseen exceptionally large flow of highly sensitive EPC information, we focus on proposing solutions to problems pertaining to two main challenges; architecture design of Discovery Services and their security. On the architecture design level, we propose novel DS architectures with focus directed towards meeting four major requirements; network scalability, query responsiveness, service extensibility and acceptance. On the security level, we propose probabilistic security schemes aiming at securing even further Discovery Services in the IoT in general, and in the EPCglobal network in particular.
Biology and physiology of Calbindin-D9k in female reproductive tissues: Involvement of steroids and endocrine disruptors
Creators: name: Choi, Kyung-Chul
name: Leung, P. C. K.
name: Jeung, Eui-Bae
Publisher: name: BioMed Central
Year: 2015

description: Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen (E2) and progesterone (P4), in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.
Molecular and Clinical Delineation of Rare Disorders of Stature
Creators: name: Hood, Rebecca
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Floating-Harbor syndrome
Weaver syndrome
Sotos syndrome with cutis laxa
high-throughput sequencing
exome sequencing
methylation array
rare genetic disorders
molecular genetics
SRCAP
EZH2
NSD1

description: There are more than 7000 described rare genetic disorders; however, the molecular basis underlying approximately half of these disorders is unknown, and the majority are currently untreatable. Stature and growth abnormalities are a common clinical feature of many rare disorders including: Floating-Harbor syndrome (FHS), a short stature syndrome characterized by delayed osseous maturation, language deficits, and unique dysmorphic facial features; Weaver syndrome, an overgrowth syndrome characterized by advanced osseous maturation, developmental delay, and macrocephaly; and Sotos syndrome with cutis laxa, an overgrowth syndrome with marked tissue laxity in addition to the typical Sotos characteristics of developmental delay, macrocephaly, and a unique facial gestalt. The genetic basis underlying these three rare stature conditions were unknown at the outset of this study. We utilized high-throughput exome sequencing approaches to investigate the molecular etiology of these rare disorders and identified truncating mutations in the final exon of SRCAP as the genetic cause underlying FHS, missense mutations in EZH2 in Weaver syndrome, and novel mutations in the Sotos syndrome gene NSD1 in Sotos syndrome with cutis laxa. Next, we investigated the spectrum of SRCAP mutations in FHS and established the clustering of truncating SRCAP mutations in the final exon as being highly suggestive of a non-haploinsufficiency mutational mechanism in FHS. Finally, global methylation array analysis identified a unique methylation ‘epi-signature’ in FHS individuals, providing further insight into FHS disease mechanism and a diagnostic signature. These studies have delineated the molecular etiology of these three rare stature/growth disorders, furthered our understanding of the associated clinical spectrum, and provided biological insight into disease pathogenesis.
Des « Ménagères Conservatrices » ?: Le militantisme des femmes des Maritimes à l’heure de la Commission royale d’enquête sur la situation de la femme au Canada, 1967-1970
Creators: name: Mélanie, Morin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Femmes
Canada
Féminisme
Deuxième vague
Histoire

description: Cette thèse s’intéresse au militantisme des femmes des Maritimes et comment elles conçoivent le féminisme et ses objectifs à l’heure de la Commission royale d’enquête sur la situation de la femme au Canada (CRESFC) en 1967. En partant d’une citation de la présidente de la Commission qui se dit déçue du militantisme des femmes de cette région, cette étude démontre que l’accolement des étiquettes aux mouvements féministes, tels que « conservateurs » et « libéraux », se complexifie lorsque les objectifs de ses militantes servent plutôt à répondre aux besoins des femmes de leur milieu à l’instar d’un agenda féministe précis. Par l’entremise d’une étude des mouvements féministes populaires et régionaux sous une commission d’enquête, cette thèse démontre simultanément que le militantisme des femmes des Maritimes sous la CRESFC déborde de ces étiquettes affiliées aux agendas féministes et que malgré les similitudes entre les militantes nationales et régionales, celles-ci doivent adapter leurs agendas afin de convenir à leur milieu. Afin de soutenir cette assertion, cette thèse propose un regard sur les entrevues avec les militantes des Maritimes devant la CRESFC, les sources audio et manuscrites des travaux de la CRESFC, les multiples fonds des groupes et associations de femmes de la région et la couverture du militantisme par la presse régionale durant cette période charnière de l’histoire du mouvement féministe sous la « deuxième vague » au Canada. D’abord, il sera démontré qu’avant même le passage de la CRESFC dans les Maritimes, les caractéristiques de la CRESFC et de la situation des femmes des Maritimes prédéterminent déjà la relation complexe entre ces deux instances. Ensuite, par une étude de la participation des femmes des Maritimes à la CRESFC, il est possible de démontrer que leur militantisme est bien plus diversifié et complexe que ce que laisse entrevoir l’historiographie actuelle et les commissaires dans les médias. Enfin, un regard sur la sphère publique des Maritimes, par le biais de la presse, démontre que les militantes de la région étaient aussi confrontées à un espace qui comporte des limites quant à la réception de leurs activités et revendications.
Zur Tagung der King Mahendra Stiftung für Naturschutz in Nepal, Deutsches Komitee, über Angepasste Technologien und Umwelterziehung als Möglichkeiten interkulturellen Verstehens im Himalayaraum
Creators: name: Von Der Heide, Susanne
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 51 (1994): ASIEN (April)
Epidemiology and Clinical Characteristics of Iatrogenic Urogenital Fistulas of Gynecological and Obstetric Origin: A 2013-2023 Study at CNHU-HKM Cotonou
Creators: name: Dodji Magloire I.
name: YEVI, Akim KOGUI DOURO,
name: Adénikè Andréa H. GBOTCHE
name: Immaculée Falone VIDEGLA
name: Jean SOSSA
name: Fred HODONOU
name: Michel Michaël AGOUNKPE
name: Gilles NATCHAGANDE
name: Hadidjatou OUAKE
name: Josué D.G. AVAKOUDJO
Publisher: name: Zenodo
Year: 2024
Subjects: Uro-genital fistula, cesarean section, hysterectomy, Benin.

description: Abstract: -

Introduction: The management of uro-genital fistulas of gynecological and obstetrical origin is a common practice in urology. This study aimed to investigate the epidemiological, clinical, and therapeutic aspects of these fistulas at the CNHU HKM in Cotonou.

Patients and Methods: This was a retrospective, descriptive, and cross-sectional study examining the epidemiological, clinical, and therapeutic aspects of uro-genital fistulas of gynecological and obstetrical origin at the CNHU HKM in Cotonou from 2013 to 2023.

Results: A total of 94 cases were collected during the study period. The average annual incidence was 12.6 cases, with a range from 1 to 37 cases. The most affected women were primarily traders (24.47%), aged between 25 and 45 years (76.59%), uneducated (43.62%), multiparous (68.09%), and with low financial income (48.94%). Uro-genital fistulas were predominantly vesico-vaginal fistulas (72.34%), mostly secondary to cesarean sections (54.26%), with 52.13% of these procedures performed urgently. Surgical treatment was predominant in 47.87% of cases. The surgical approach included 41.48% of cases treated through vaginal repair and 41.48% through abdominal repair. The success rate of surgical interventions was 87.23%.

Conclusion: The management of uro-genital fistulas of gynecological and obstetrical origin remains a challenge for urologists in Africa.
The International Classification of Functioning as an explanatory model of health after distal radius fracture: A cohort study
Creators: name: Harris, Jocelyn E
name: MacDermid, Joy C
name: Roth, James
Publisher: name: BioMed Central
Year: 2016

description: Background: Distal radius fractures are common injuries that have an increasing impact on health across the lifespan. The purpose of this study was to identify health impacts in body structure/function, activity, and participation at baseline and follow-up, to determine whether they support the ICF model of health. Methods: This is a prospective cohort study of 790 individuals who were assessed at 1 week, 3 months, and 1 year post injury. The Patient Rated Wrist Evaluation (PRWE), The Wrist Outcome Measure (WOM), and the Medical Outcome Survey Short-Form (SF-36) were used to measure impairment, activity, participation, and health. Multiple regression was used to develop explanatory models of health outcome. Results: Regression analysis showed that the PRWE explained between 13% (one week) and 33% (three months) of the SF-36 Physical Component Summary Scores with pain, activities and participation subscales showing dominant effects at different stages of recovery. PRWE scores were less related to Mental Component Summary Scores, 10% (three months) and 8% (one year). Wrist impairment scores were less powerful predictors of health status than the PRWE. Conclusion: The ICF is an informative model for examining distal radius fracture. Difficulty in the domains of activity and participation were able to explain a significant portion of physical health. Post-fracture rehabilitation and outcome assessments should extend beyond physical impairment to insure comprehensive treatment to individuals with distal radius fracture.
Seismic Fragility Analysis of Reinforced Concrete Shear Wall Buildings in Canada
Creators: name: Rafie Nazari, Yasamin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: fragility curves
vulnerability analysis
nonlinear modelling
dynamic analysis
seismic assessment
shear wall buildings

description: Damage observed after previous earthquakes indicates that a large number of existing buildings are vulnerable to seismic hazard. This research intends to assess seismic vulnerability of regular and irregular shear wall buildings in Canada, having different heights and different levels of seismic design and detailing. As seismic hazard is a probabilistic event, a probabilistic methodology has been adopted to assess the seismic vulnerability of the shear wall buildings. The proposed research encompasses a comprehensive fragility analysis for seismic vulnerability of shear wall buildings in Canada. The first phase of the investigation involves shear wall buildings with different heights (hence different structural periods), designed based on the 2010 National Building Code of Canada. The second phase involves shear wall buildings designed prior to 1975, representing pre-modern seismic code era. The third phase involves the evaluation of pre-1975 shear wall buildings with irregularities. 3-Dimensional simulations of the buildings were constructed by defining nonlinear modelling for shear wall and frame elements. These models were subjected to dynamic time history analyses conducted using Perform 3D software. Two sets of twenty earthquake records, compatible with western and eastern Canadian seismicity, were selected for this purpose. Spectral acceleration and peak ground acceleration were chosen as seismic intensity parameters and the first storey drift was selected as the engineering demand parameter which was further refined for irregular cases. The earthquake records were scaled to capture the structural behaviour under different levels of seismic excitations known as Incremental Dynamic Analysis. The resulting IDA curves were used as the input for seismic fragility analysis. Fragility curves were derived as probabilistic tools to assess seismic vulnerability of the buildings. These curves depict probability of exceeding immediate occupancy, life safety and collapse prevention limit states under different levels of seismic intensity.
A stepwise framework for the normalization of array CGH data
Creators: name: Khojasteh, Mehrnoush
name: Lam, Wan
name: Ward, Rabab Kreidieh
name: MacAulay, Calum
Publisher: name: BioMed Central
Year: 2016

description: Background: In two-channel competitive genomic hybridization microarray experiments, the ratio of the two fluorescent signal intensities at each spot on the microarray is commonly used to infer the relative amounts of the test and reference sample DNA levels. This ratio may be influenced by systematic measurement effects from non-biological sources that can introduce biases in the estimated ratios. These biases should be removed before drawing conclusions about the relative levels of DNA. The performance of existing gene expression microarray normalization strategies has not been evaluated for removing systematic biases encountered in array-based comparative genomic hybridization (CGH), which aims to detect single copy gains and losses typically in samples with heterogeneous cell populations resulting in only slight shifts in signal ratios. The purpose of this work is to establish a framework for correcting the systematic sources of variation in high density CGH array images, while maintaining the true biological variations. Results: After an investigation of the systematic variations in the data from two array CGH platforms, SMRT (Sub Mega base Resolution Tiling) BAC arrays and cDNA arrays of Pollack et al., we have developed a stepwise normalization framework integrating novel and existing normalization methods in order to reduce intensity, spatial, plate and background biases. We used stringent measures to quantify the performance of this stepwise normalization using data derived from 5 sets of experiments representing self-self hybridizations, replicated experiments, detection of single copy changes, array CGH experiments which mimic cell population heterogeneity, and array CGH experiments simulating different levels of gene amplifications and deletions. Our results demonstrate that the three-step normalization procedure provides significant improvement in the sensitivity of detection of single copy changes compared to conventional single step normalization approaches in both SMRT BAC array and cDNA array platforms. Conclusion: The proposed stepwise normalization framework preserves the minute copy number changes while removing the observed systematic biases.
Mercury Bioavailability in Traditional Food and the Effect of Selenium
Creators: name: Yassine, Rami
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Mercury
Bioavailability
Selenium
Food
Aboriginal

description: Methylmercury (MeHg) is a potent neurotoxin capable of crossing the blood-brain barrier causing a profound negative impact on the central nervous system. After its release, Hg may be transported worldwide and eventually deposited in colder Arctic regions. Exposure of Aboriginal communities to MeHg occurs primarily through the consumption of traditional food. Dietary exposure studies are conducted using the total concentration of mercury in the food multiplied by the food consumption rate. This method does not take into account the oral bioavailability of Hg. Therefore, this study determines the bioavailability of Hg in four key traditional foods to provide a better estimation of Hg exposure and to improve the characterization of overall Hg risk to human health. We found that Hg concentrations significantly decreased for all foods after undergoing an in-vitro digestion process. Hg bioaccessibility percentage of ringed seal liver was 32.3%, ringed seal muscle was 69.0%, lake trout muscle was 28.8%, and lastly air-dried beluga muscle was 34.0%. Furthermore, no relationship was observed between bioaccessible Hg concentrations and original Hg concentrations in the raw food. The concentration of MeHg in the bioaccessible fraction was also examined and found to be significantly higher in muscle tissues than in the liver. Bioavailability of the foods was determined using Caco-2 cells. Hg bioavailability percentages were found to be 0.42% for RSL 5.24% for RSM, 7.30% for ADB, and finally, 12.70% for LT. Correlations were found between increased Hg uptake and higher percentages of bioaccessible MeHg as well as lower concentrations of bioaccessible selenium. Lastly, a significant decrease in MeHg uptake after 24 hours was observed when co-incubating with selenium. These results suggest that risk assessments should incorporate bioaccessibility and bioavailability when estimating mercury exposure. Additionally, nutrients such as selenium in traditional food may play a role in reducing mercury uptake in the gut.
The Wisdom of the Scribe: A Socio-Rhetorical and Theological Interpretation of Sirach 38:24–39:11
Creators: name: Finbow, Douglas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: wisdom
scribe
Sirach
Septuagint

description: This thesis contends that the Greek text of Sirach 38:24–39:11 is a rhetorical elaboration of σοφι'α γραμματε'ως as a divinely inspired wisdom uttered by a learned scholar who embodies a dynamic correlation of the universal wisdom “poured out” at creation with the particular wisdom revealed to Israel in its covenantal history. Specifically, the thesis contends that Sirach uses the Hellenistic social concept σχολη' to argue that freedom from manual labour, engagement in ε λευθε' ριος παιδει'α and an appropriate piety before the creator, disposes the scribe to being filled with “the spirit of understanding” and to uttering a new, superior wisdom which will be manifest in a continued, but divinely informed, correlation of παιδει'α with “glory (καυχα' ομαι) in the law of the Lord’s covenant.” Beginning with a review of the complex textual and interpretive history of Sirach 38:24-39:11, the dissertation proposes a socio-rhetorical interpretive analytics as an innovative and productive approach to the Greek text of the discourse. After considering innertexture, intertexture, socio-cultural texture and ideological texture, the research argues that this passage is a discrete and coherent rhetorical unit intended to elaborate σοφι'α γραμματε'ως as a divine gift of understanding bestowed on a learned scholar who embodies the discipline of παιδει'α, theachievement of personal excellence (α ρετη') and a faithful piety before the God of creation, election and covenant with Israel. The result is that Jewish intellectual and wisdom traditions are presented in a register equal with and superior to the highest levels of Hellenistic wisdom. Faithful scribes of the Jewish Egyptian Diaspora community may now live and practice their vocation within the social expectations of Hellenistic scribal culture and at the same time remain deeply faithful to their traditional identity rooted in election and covenant.
E2F6: A Unique Regulator of Post-natal Cardiac Growth, Death, and Function
Creators: name: Major, Jennifer Lynn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Dilated Cardiomyopathy
E2F

description: Rationale/Background: The adult mammalian heart has a very limited potential for regeneration due to cardiomyocyte cell cycle withdrawal which occurs shortly after birth. One potential avenue to repair the heart following stress/injury is to reprogram pre-existing cardiomyocytes to re-enter the cell cycle. The E2F family is a group of transcription factors which ubiquitously regulate the cell cycle, but it has previously been difficult to fully appreciate their role in the post-natal myocardium due to either redundancy or embryonic lethality of genetic models. Thus we generated a dominant negative model of the E2F/Rb pathway via expression of the unique transcriptional repressor E2F6 in postnatal myocardium. E2F6 transgenic (Tg) mice developed dose dependent Dilated Cardiomyopathy (DCM) and sudden death without hypertrophy or apoptosis. This was accompanied by the partial loss of E2F3 (critical for cardiac development) and connexin-43 important for metabolic and electrical coupling. Methods/Results: In this thesis E2F6-Tg mice were examined for markers of cardiac differentiation/ function and exposed to stressors to evaluate the capacity for the E2F pathway to regulate cardiomyocyte growth (isoproterenol) and death (doxorubicin and cobalt chloride). E2F6-Tg mice were twice as sensitive to isoproterenol as their Wt counterparts due to the observed activation of a β2-adrenergic survival pathway. Cardiac hypertrophy in E2F6-Tg mice was accompanied by the rescue of E2F3 expression. Treatment of neonatal cardiomyocytes isolated from Wt and E2F6-Tg pups with cobalt chloride revealed a protective effect for E2F6 against apoptosis. Doxorubicin exposure led to the loss of E2F6 protein and abolished its protective effect. Examination of neonatal hearts and cardiomyocytes isolated from them demonstrated a shift in the cell cycle and metabolic profiles of E2F6-Tg myocardium. Tg cardiomyocytes show decreased glycolysis and a dramatic increase in the regulator of ketolysis, β-hydroxybutyrate dehydrogenase (BDH1), prior to DCM. The substrate of BDH1 (β-hydroxybutyrate) was demonstrated to influence the levels of CX-43 in cardiomyocytes. E2F6 also deregulated expression of T-cap which has been linked to human DCM. Conclusions: I provide evidence that the E2F pathway can regulate growth, death, and differentiation through a variety of mechanisms which link the cell cycle and metabolism to growth and survival to critically govern post-natal cardiac function. Furthermore, I reveal a new biomarker (BDH1) for early DCM which may be useful in diagnosis/ treatment of idiopathic cases of disease.
Exploring Conspicuous Luxury Consumption In Iran: The Role Of Individual Factors and Consumer Knowledge
Creators: name: Kermani, Mohammad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Conspicuous consumption
Luxury
Status
Culture
Iranian
Bandwagon consumption
Snob consumption
Consumer Knowledge

description: This research tested a conceptual model predicting the propensity to engage in two distinct forms of conspicuous consumption (bandwagon and snob consumption) that was developed by Kastanakis and Balabanis (2014) in a collectivistic Iranian context. This study found that this conceptual model was more successful in accounting for the variance in bandwagon consumption (i.e., conformity seeking conspicuous luxury consumption) than snob consumption (i.e., uniqueness seeking conspicuous luxury consumption) in the Iranian context. In addition to status seeking, it was found that consumer susceptibility to normative influence (CSNI) and consumer need for uniqueness (CNFU) mediates the influence of self-concept on bandwagon consumption. This finding suggests that the relationship between snob consumption and CNFU may differ in the Iranian context. Results also show that the relationships between CSNI, unpopular counter choice conformity (a sub-construct of CNFU) and status seeking with bandwagon consumption were all negatively moderated by consumer knowledge for fashion luxury goods. These findings extend the original conspicuous consumption model and provide some insight for the development of marketing strategies in Iran.
Phosphatidylinositol 4-kinase III Beta Promotes Oncogenic Signaling In Breast Cancer by Controlling Endocytosis
Creators: name: MacDonald, Spencer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Breast cancer
Rab11a
Phosphatidylinositol 4-phosphate
Recycling
Endocytosis
Signaling

description: Endosomes are now recognized as important sites for regulating signal transduction. Here we show that the lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIβ) regulates both endocytic kinetics and receptor signaling in breast cancer cells. PI4KIIIβ generates phosphatidylinositol 4-phosphate from phosphatidylinositol and is highly expressed in a subset of breast cancers. However, the molecular mechanism by which PI4KIIIβ promotes breast cancer is unclear. We demonstrate that ectopic PI4KIIIβ expression increases the rates of both endocytic internalization and recycling. Furthermore, PI4KIIIβ deletion reduces endocytic kinetics. Regulation of endocytic function by PI4KIIIβ is independent of its kinase activity but requires interaction with the Rab11a GTPase. Additionally, we find that PI4KIIIβ activates IGF-IRβ signaling, dependent on endosome function. Finally, we observe that PI4KIIIβ deletion decreases the growth rate of mammary tumours in mice. Our work suggests a novel regulatory role for PI4KIIIβ in endosome function and plasma membrane receptor signaling, providing a mechanism by which increased PI4KIIIβ expression could promote breast cancer oncogenesis.
Formation and stability of cubic ice in water droplets
Creators: name: Murray, Benjamin J.
name: Bertram, Allan K.
Publisher: name: Royal Society of Chemistry
Year: 2016

description: There is growing evidence that a metastable phase of ice, cubic ice, plays an important role in the Earth’s troposphere and stratosphere. Cubic ice may also be important in diverse fields such as cryobiology and planetary sciences. Using X-ray diffraction, we studied the formation of cubic ice in pure water droplets suspended in an oil matrix as a function of droplet size. The results show that droplets of volume median diameter 5.6 μm froze dominantly to cubic ice with stacking faults. These results support previous suggestions that cubic ice is the crystalline phase that nucleates when pure water droplets freeze homogeneously at [similar]235 K. It is also shown that as the size of the water droplets increased from 5.6 to 17.0 μm, the formation of the stable phase of ice, hexagonal ice, was favoured. This size dependence can be rationalised with heat transfer calculations. We also investigated the stability of cubic ice that forms in water droplets suspended in an oil matrix. We observe cubic ice up to 243 K, much higher in temperature than observed in many previous studies. This result adds to the existing literature that shows bulk ice Ic can persist up to [similar]240 K. The transformation of cubic ice to hexagonal ice also showed a complex time and temperature dependence, proceeding rapidly at first and then slowing down and coming to a halt. These combined results help explain why cubic ice forms in some experiments described in the literature and not others.
Ulysses - an application for the projection of molecular interactions across species
Creators: name: Kemmer, Danielle
name: Huang, Yong
name: Shah, Sohrab P.
name: Lim, Jonathan
name: Brumm, Jochen
name: Yuen, Macaire M.
name: Ling, John
name: Xu, Tao
name: Wasserman, Wyeth W.
name: Ouellette, B. F. F.
Publisher: name: BioMed Central
Year: 2015

description: We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins, and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface http://www.cisreg.ca/ulysses .
Development of real-time functional magnetic resonance imaging pipeline at Donders Institute
Creators: name: Niazi, Adnan
Publisher: name: figshare
Year: 2012
Subjects: subject: Neuroscience
subject: Behavioral Neuroscience
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Engineering

description: Real-time functional magnetic resonance (rtfMRI) imaging is a relatively new technique to compute moment-to-moment changes in brain activations corresponding to a particular experimental manipulation. In this report, the inner workings of the Donder rtfMRI pipeline is described.
Investigating N2pc ERP for its use in brain computer interface (BCI) applications
Creators: name: Niazi, Adnan
name: Yap, Sebastian
Publisher: name: figshare
Year: 2012
Subjects: subject: Neuroscience
subject: Behavioral Neuroscience
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Engineering

description: This study investigated the use of N2pc (Negativity around 200 ms in posterior contralateral) ERP for its potential use in brain computer interface applications. To the best of our knowledge, the N2pc feature has never been investigated in this context before. All existing N2pc research is mainly focused on the psychological aspects of N2pc as a neural correlate of spatial attention. In this paper, a two phase research is described which culminated in the final BCI application. Exploratory offline tests were conducted in the first phase to identify the challenges involved in using N2pc for BCI. This was followed by the development of an online audio based game in the second phase, controlled by the N2pc in the EEG signals. Both online and offline studies used single trial classification. The results of the study implicates that N2pc has a very promising future with regards to its use in a robust two or three class BCI.
Generation of Vortex Beam Superpositions Using Angular Gratings
Creators: name: Dicaire, Marie-Claude
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: vortex beam
angular grating
integrated optics device

description: Beams of light carrying orbital angular momentum, such as vortex beams, have many applications in imaging and micromanipulation. We focus on applications in communication, in particular for quantum key distribution, where the security of communication channels is enhanced with the laws of quantum mechanics. However, this procedure requires superpositions of vortex beams. We want to generate such beams using integrated optics components due to their small size and their advantages in scalability and stability. Angular gratings, which are ring resonators with an embedded Bragg grating, are integrated structures known to generate vortex beams. We propose that a ring resonator with two embedded Bragg gratings, each on the inner and outer sidewalls, would generate a superposition of vortex beams. We verify this claim through analytical models, simulations and experiments.
Bias in Parental Reports? The Moderating Effect of Parents’ Childhood Peer Victimization on Their Reports of Their Child’s Current Experiences with Bullying and Depression Symptoms
Creators: name: Dubeau, Katherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Bullying
Peer victimization
Parent
Depression

description: Bullying is a prevalent and pervasive issue that can have both immediate and long-term detrimental effects on victims. Researchers have shown that victims of bullying may continue to experience negative outcomes into adulthood, where they may possibly have victimized children of their own. We examined whether parents’ history of peer victimization moderated the relation between their children’s self-reported peer victimization and children’s depression symptoms in a sample of 417 parent-child dyads from the McMaster Teen Study. Possible confounding variables, such as sex of the child, parent’s relationship to the child, parental education, and household income, were controlled for statistically. Consistent with our initial prediction, results indicated that parents’ past victimization moderated the relation between child peer victimization and depression symptoms, but only when parent reports of child depression symptoms were used, not child self-reports. Implications for parental history of bullying as a potential source of bias in reports are discussed.
Additional file 1 of Has cross-level clinical coordination changed in the context of the pandemic? The case of the Catalan health system
Creators: name: Campaz-Landazabal, Daniela
name: Vargas, Ingrid
name: Sánchez, Elvira
name: Cots, Francesc
name: Plaja, Pere
name: Perez-Castejón, Joan Manuel
name: Sánchez-Hidalgo, Antonio
name: Vázquez, María Luisa
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Science Policy

description: Supplementary Material 1
„Frieden im Pazifik!? Bougainville, Salomonen, Fidschi und West- Papua: Westpazifische Inselstaaten zwischen Auflösungen und Friedenslösungen"
Creators: name: Holtz, Andreas
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 108 (2008): ASIEN (Juli)
Debat onderwijsachterstandenbeleid: the show must go on
Creators: name: Driessen, Geert
Publisher: name: Didactief
Year: 2018
Subjects: onderwijsachterstanden
budget
extra geld

description: Minister Slob van Onderwijs heeft een brief geschreven over hetonderwijsachterstandenbeleid (oab). Het debat daarover vindt aanstaandedonderdag plaats. Let op, het gaat in dit beleid louter nog om het verdelen vangeld, schrijft Geert Driessen.
Additional file 2 of Has cross-level clinical coordination changed in the context of the pandemic? The case of the Catalan health system
Creators: name: Campaz-Landazabal, Daniela
name: Vargas, Ingrid
name: Sánchez, Elvira
name: Cots, Francesc
name: Plaja, Pere
name: Perez-Castejón, Joan Manuel
name: Sánchez-Hidalgo, Antonio
name: Vázquez, María Luisa
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Science Policy

description: Supplementary Material 2
Additional file 3 of Has cross-level clinical coordination changed in the context of the pandemic? The case of the Catalan health system
Creators: name: Campaz-Landazabal, Daniela
name: Vargas, Ingrid
name: Sánchez, Elvira
name: Cots, Francesc
name: Plaja, Pere
name: Perez-Castejón, Joan Manuel
name: Sánchez-Hidalgo, Antonio
name: Vázquez, María Luisa
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Science Policy

description: Supplementary Material 3
Implementation of Fixed Point FFT(512,1K,2K,4K) on FPGA.pdf
Creators: name: Niazi, Adnan
Publisher: name: figshare
Year: 2012
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Engineering

description: The fast Fourier transform (FFT) is one of the most widely used and important signal processing functions, for example, in applications related to digital communications and image processing. Since the computational complexity of the FFT is O(N log2N), where N the number of inputs, the FFT potentially requires multi-cycle processing, and can become a major bottleneck for overall system performance. To relieve this bottleneck, many commercial FPGA IP blocks provide a streaming form of the FFT with single-cycle-per-sample throughput. This high-throughput form of FFT comes by exploiting the locality of reference and massive parallelism offered by modern FPGA fabrics. Multiple butterflies can be easily implemented on the FPGA. The twiddle factors and the intermediates data samples can be stored either in block RAM or Distributed RAM or a combination of both. This completely eliminates the need for off chip memory access which may slow down the FFT considerably. This report descirbes the implementation of FFT on a Xilinx-6 FPGA.
Efficacy and Safety of Pharmacological Thromboprophylactic Agents for the Prevention of Venous Thromboembolism after Major Abdominal Surgery
Creators: name: Al Rawahi, Bader
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: thrombosis
thromboprophylaxis
abdominal
surgery

description: Statement of the problem: The type and duration of pharmacological thromboprophylaxis post major abdominal surgery remains controversial. Methods of investigation: A systematic review and pooled analysis of literature was performed to assess the risk benefit ratio of the different pharmacological thromboprophylaxis agents compared to placebo or no thromboprophylaxis post major abdominal surgery. A survey of the clinical practice among both general surgeons and thrombosis expert was conducted. Results: The systematic review demonstrated that all five pharmacological thromboprophylaxis regimens were associated with similar rates of overall VTE. The 95% CI of the different estimates overlapped indicating no statistically significant difference between any of the pharmacological interventions and placebo. While all the surgeons and thrombosis experts recommended thromboprophylaxis post major abdominal surgery, over 70% of them recommended it during hospitalization only. Conclusion: Pharmacological thromboprophylaxis was not associated with a significant benefit in reducing the rate of overall VTE events post major abdominal surgery. There is an agreement between general surgeons and thrombosis experts in using LMWH for thromboprophylaxis post major abdominal surgery. However, there is still equipoise around the use of pharmacological thromboprophylaxis post discharge.
Effect of music tempo in First-Person Shooter on arousal and aggression
Creators: name: Niazi, Adnan
Publisher: name: figshare
Year: 2012
Subjects: Computer Engineering

description: The present study used a between subjects, post-test only design to investigate the impact of background music (low tempo music vs. high tempo music) on arousal and aggression of a player playing a first person shooter video game: Counter-Strike. Arousal was measured using Skin Conductance Level (SCL) and aggression using an Implicit Attitude Test (IAT). Results indicate no significant differences in the arousal and aggression between the two conditions implying that music tempo plays no role in manipulating the arousal and aggression of a player in gaming context. The study did, however, find a significant correlation between arousal and aggression in high tempo condition, suggesting a general trend that more aroused subjects showed more aggressive cognitions. No significant correlation was found in low tempo condition.
Additional file 5 of Has cross-level clinical coordination changed in the context of the pandemic? The case of the Catalan health system
Creators: name: Campaz-Landazabal, Daniela
name: Vargas, Ingrid
name: Sánchez, Elvira
name: Cots, Francesc
name: Plaja, Pere
name: Perez-Castejón, Joan Manuel
name: Sánchez-Hidalgo, Antonio
name: Vázquez, María Luisa
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Science Policy

description: Supplementary Material 5
Akrav Levy 2007
Creators: name: Fet, Victor
name: Soleglad, Michael E.
name: Zonstein, Sergei L.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Akravidae
Akrav

description: Genus AKRAV Levy, 2007
 Akrav Levy, 2007: 92. Type species Akrav israchanani Levy, 2007 (by original designation).
No other species known. RECORDS:
 Akrav: Lubin & Gavish-Regev, 2008: 135; Soleglad, Kovařík & Fet, 2009: 3; Vignoli & Prendini, 2009: 3 (Table I).
description: Published as part of Fet, Victor, Soleglad, Michael E. & Zonstein, Sergei L., 2011, The genus Akrav Levy, 2007 (Scorpiones: Akravidae) revisited, pp. 1-49 in Euscorpius 2011 (134) on pages 1-49, DOI: 10.18590/euscorpius.2011.vol2011.iss134.1, http://zenodo.org/record/13222252
Seasonality and weather-driven variability of transpacific transport
Creators: name: Holzer, Mark
name: Hall, Timothy M.
name: Stull, Roland B., 1950-
Publisher: name: American Geophysical Union
Year: 2011

description: We quantify transport from the industrialized regions of E Asia using the transit-time probability density function, , to isolate the role of transport from any other factors, such as chemistry and deposition. Using the offline transport model MATCH driven by NCEP reanalyses, we calculate , which is the mass fraction of air that had its last contact with the E-Asian source region during a given day, for each day of a three-year period. Ensemble means of  establish the climatological seasonal-mean transport from E Asia. Export from the source region is most efficient in spring, with nearly all E-Asian air involved in transpacific transport. In summer, E-Asian air is transported aloft across the Pacific and, in nearly equal measure, west over SE Asia to the Middle East. Winter transport is similar to that of spring, except winter has low-level transport to SE Asia. Fall transport is intermediate between that of summer and winter. For all seasons, the most probable transit times to N America are 6–8 days in the mid-to-upper troposphere and approximately one week (two for summer) longer at the surface. The surface signal of E-Asian air over N America is strongest in spring. Daily variability of transpacific transport is quantified in terms of the transit-time partitioned burden of E-Asian air over western N America. The standard deviation of the transit-time partitioned fluctuations has a nearly universal dependence on the corresponding seasonal-mean burden. The standard deviation peaks several days before the burden at a transit time of ∼7 days. Lagged event and nonevent composites, based on the western N-American burden of E-Asian air, reveal that transport events are associated with dipolar wind perturbations over the eastern Pacific that are positioned and phased to receive enhanced Asian outflow. Surface-pressure correlations are consistent with an associated strengthened Pacific High and weakened Aleutian Low. An edited version of this paper was published by AGU. Copyright 2005 American Geophysical Union.
Weingartener Asiengespräche 2008: Wirtschaftliche Vernetzungen im asiatisch-pazifischen Raum und ihre politischen und kulturellen Rahmenbedingungen
Creators: name: Rother, Stefan
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 108 (2008): ASIEN (Juli)
Additional file 1 of Chinook salmon depth distributions on the continental shelf are shaped by interactions between location, season, and individual condition
Creators: name: Freshwater, Cameron
name: Anderson, Sean C.
name: Huff, David D.
name: Smith, Joseph M.
name: Jackson, Doug
name: Hendriks, Brian
name: Hinch, Scott G.
name: Johnston, Stephen
name: Trites, Andrew W.
name: King, Jackie
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1. Supplementary analyses evaluating alternative model structures.
Akrav Levy 2007
Creators: name: Fet, Victor
name: Soleglad, Michael E.
name: Zonstein, Sergei L.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Akravidae
Akrav

description: Akrav ’s place within Recent scorpions
 Based on the detailed character descriptions discussed above, we now consider Akrav ’s position within Recent scorpions.
description: Published as part of Fet, Victor, Soleglad, Michael E. & Zonstein, Sergei L., 2011, The genus Akrav Levy, 2007 (Scorpiones: Akravidae) revisited, pp. 1-49 in Euscorpius 2011 (134) on pages 1-49, DOI: 10.18590/euscorpius.2011.vol2011.iss134.1, http://zenodo.org/record/13222252