cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The role of cardiac microvascular endothelial cells in drug induced cardiovascular toxicity
Creators: name: Smith, Emma
Publisher: name: University of Liverpool Repository
Year: 2016

description: Cardiovascular toxicity is defined as a severe and potentially fatal adverse reaction to certain drugs. It is one of the leading causes of attrition in drug development. Cardiovascular toxicity research has primarily focused on the role of cardiomyocytes in functional and structural cardiovascular toxicity. However, there is a growing awareness that non-myocyte cells may contribute to cardiovascular toxicity. The heart is a highly vascularised organ. Endothelial cells from the heart were compared between rat and human, as well as between different vascular beds with the use of human cardiac microvascular endothelial cells (HCMECs) and human dermal microvascular endothelial cells (HDMECs). This data demonstrated ligand induced activation of EGFR-1 in HCMEC indicating the presence of functional EGFR1. Analysis of mRNA expression of EGFR1-4 revealed higher expression of both EGFR1 and EGFR2 in HCMEC compared with HDMEC. The role of EGFR-2 (Her2) in drug-induced cardiovascular toxicity was analysed with use of Herceptin® and doxorubicin treatment. Herceptin® and doxorubicin are known to induce cardiovascular toxicity in the clinic. The effect of these drugs on the endothelial tight junction barrier was tested, revealing that Herceptin® and doxorubicin are able to induce barrier perturbment and decreased barrier function in HCMEC. Herceptin® treatment had no effect on the tight junction barrier function in HDMECs. Previous work in the group has identified a role for extracellular-signal-regulated kinase 5 (ERK5) in regulation of endothelial cell survival. The role of ERK5 in endothelial tight junction regulation was investigated using small molecule inhibitors, siRNA transient gene silencing and adenoviral–mediated overexpression of ERK5 to reveal that ERK5 plays an important role in tight junction regulation and endothelial barrier function. Statins are clinically used to lower plasma LDL-cholesterol levels in patients via inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). Simvastatin activated ERK5 in endothelial cells via a pathway requiring MEKK3 and MEK5 leading to increased tight junction formation and increased barrier function, providing a possible mechanism for the pleiotropic effects of statins on endothelial cells. Analysis of the effects of a range of anti-cancer drugs with known cardiovascular toxicity liability revealed these drugs could disrupt tight junctions and decrease barrier function. Pre-incubation with simvastatin protected the endothelial cells from drug induced perturbment of endothelial tight junction formation and the associated decrease in barrier function. The data shows the importance of drug-induced endothelial injury in cardiovascular toxicity and highlights potential for therapeutically targeting vasculature to protect against drug-induced vascular injury.
РОЛЬ РОСФИНМОНИТОРИНГА В ФИНАНСОВОМ КОНТРОЛЕ
Creators: name: Коваленко Е.В.
name: Мазняк В.К.
name: Тарновский А.А.
Publisher: name: Образование и право
Year: 2022
Subjects: Федеральная служба по финансовому мониторингу
Росфинмониторинг
финансовый мониторинг
финансовый контроль
финансовое право
функции
федеральный орган исполнительной власти
проблемы правоприменения.

description: В статье приводятся общие положения о финансовом мониторинге и финансовом контроле. В работе раскрываются функции и задачи Федеральной службы по финансовому мониторингу, подчеркивающие роль данного федерального органа исполнительной власти. Также в статье раскрываются вопросы в взаимодействия и сотрудничества Федеральной службы по финансовому мониторингу с иными органами власти Российской Федерации и проблемные аспекты данного взаимодействия. На основе выявленных проблем были предложены различные пути решения для оптимизации деятельности и взаимодействия данного федерального органа исполнительной власти с иными участниками в процессе финансового контроля.
SISO Output Affine Feedback Transformation Group and Its Faa di Bruno Hopf Algebra
Creators: name: Gray, W. Steven
name: Ebrahimi-Fard, Kurusch
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The general goal of this paper is to identify a transformation group that can be used to describe a class of feedback interconnections involving subsystems which are modeled solely in terms of Chen-Fliess functional expansions or Fliess operators and are independent of the existence of any state space models. This interconnection, called an output affine feedback connection, is distinguished from conventional output feedback by the presence of a multiplier in an outer loop. Once this transformation group is established, three basic questions are addressed. How can this transformation group be used to provide an explicit Fliess operator representation of such a closed-loop system? Is it possible to use this feedback scheme to do system inversion purely in an input-output setting? In particular, can feedback input-output linearization be posed and solved entirely in this framework, i.e., without the need for any state space realization? Lastly, what can be said about feedback invariants under this transformation group? A final objective of the paper is to describe the Lie algebra of infinitesimal characters associated with the group in terms of a pre-Lie product.
description: revised manuscript; title and abstract changed; new material added
САМООГРАНИЧЕНИЕ ВЕРХОВНОЙ ВЛАСТИ В ПЕРИОД АБСОЛЮТИЗМА: ТЕНДЕНЦИИ И НОРМАТИВНОЕ ЗАКРЕПЛЕНИЕ
Creators: name: Гаврикова А.М.
Publisher: name: Образование и право
Year: 2022
Subjects: верховная власть
самоограничение
монархия
абсолютизм
самодержавие
история государства и права.

description: В статье рассматриваются становление и основные этапы формирования правовых механизмов ограничения верховной власти в Российской империи в период со второй половины XVIII века до начала XX века. В хронологической последовательности исследуется система государственного управления, определяется роль создаваемых Императорами государственных органов в становлении демократического общества в истории России.
Biochemical and bioinformatic analysis of the MYO19 motor domain
Creators: name: Yengo, Christopher M.
name: Adikes, Rebecca C.
name: Quintero, Omar A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Mitochondrial dynamics are dependent on both the microtubule and actin cytoskeletal systems. Evidence for the involvement of myosin motors has been described in many systems, and until recently a candidate mitochondrial transport motor had not been described in vertebrates. Myosin-XIX (MYO19) was predicted to represent a novel class of myosin and had previously been shown to bind to mitochondria and increase mitochondrial network dynamics when ectopically expressed. Our analyses comparing ∼40 MYO19 orthologs to ∼2000 other myosin motor domain sequences identified instances of homology well-conserved within class XIX myosins that were not found in other myosin classes, suggesting MYO19-specific mechanochemistry. Steady-state biochemical analyses of the MYO19 motor domain indicate that Homo sapiens MYO19 is a functional motor. Insect cell-expressed constructs bound calmodulin as a light chain at the predicted stoichiometry and displayed actin-activated ATPase activity. MYO19 constructs demonstrated high actin affinity in the presence of ATP in actin-cosedimentation assays, and translocated actin filaments in gliding assays. Expression of GFP-MYO19 containing a mutation impairing ATPase activity did not enhance mitochondrial network dynamics, as occurs with wild-type MYO19, indicating that myosin motor activity is required for mitochondrial motility. The measured biochemical properties of MYO19 suggest it is a high-duty ratio motor that could serve to transport mitochondria or anchor mitochondria, depending upon the cellular microenvironment.
title: Emancipatory horizons: The possibility of a revolutionary architectural practice
Creators: name: De Stefani Casanova, Patricio
Publisher: name: University of Liverpool Repository
Year: 2013

description: Architecture has always been tied to social change, but also to social reproduction. Architects have sought to challenge social structures before, but this tendency seems to be in utter decline, is an emancipatory practice of architecture still possible? What prevents architecture from engaging in radical social and spatial transformation? To find out if it can still have a progressive function within society, its material relation to capital must be unravelled. The active human body, abstract labour, abstract space, fixed capital, landed property, and rent are crucial concepts to understand the spatial logic of capitalism. This research examines these theoretical issues through the historical case of UNCTAD III building in Chile, one of the last attempts to challenge the capitalist production of space. Through this case the difficult questions concerning the role of architecture within capitalist society and what are the possibilities for an alternative practice in our current conditions can be addressed. A radical alternative through architecture must acknowledge both its autonomy and dependence from the cities produced by capitalism if it wishes to address concrete change. To examine the function of architecture within the capitalist mode of production in its general or abstracted form, and assess the possibility of an architectural practice which actively confronts such function, constitutes the main objective of this research. A secondary aim is to analyse a concrete historical example of an antagonist relation between architecture and capital, in order to test the feasibility of my theoretical hypotheses. The achievement of this research has been to examine (theoretically and historically) the relations between architecture and capitalism in order to realistically confront the question of its political role in the struggle for the transformation of this mode of production.
СОЦИОЛОГИЧЕСКОЕ НАПРАВЛЕНИЕ В СОВЕТСКОЙ ЮРИСПРУДЕНЦИИ 1920-30-Х ГОДОВ
Creators: name: Львов А.В.
name: Звонарев А.В.
name: Пашенцев Д.А.
Publisher: name: Образование и право
Year: 2022
Subjects: советская юриспруденция
теория права
понятие права
социологическая юриспруденция
Стучка
Пашуканис
Вышинский
правопонимание.

description: В статье показаны особенности и направления развития социологического подхода к праву в работах ученых-правоведов конца 1920начала 1930-х годов. Отмечается, что формирование советской теории права с самого начала столкнулось с целым рядом принципиальных проблем, что породило острые дискуссии и разные позиции. Проанализированы взгляды на право П. И. Стучки, который дал определение права в широком и узком смысле. Исследованы воззрения Е.Б. Пашуканиса, который считал, что право представляет собой систему правоотношений, которые являются материальной формой права, тогда как нормы и правосознание составляют его идеологическую форму. Подчеркивается роль Совещания по вопросам науки советского государства и права 1938 года, на котором было утверждены официальные понятия права вообще и советского права, остававшиеся каноническими вплоть до конца 1980-х годов.
title: Development of techniques for the analysis of protein: glycosaminoglycan interactions in solution.
Creators: name: Hughes, Ashley
Publisher: name: University of Liverpool Repository
Year: 2015

description: Glycosaminoglycans (GAGs), such as Heparan Sulfate (HS), are vital components, of all multicellular organisms, with confirmed roles in development, cell-cell communication and diseases such as dementia and cancer. As such, the interaction of this important group of molecules with proteins is an important process to comprehend and improvements to current techniques are sought. To achieve this HS and its structural analogue heparin, were investigated in various biological systems to simultaneously improve our collective knowledge of the biological systems employed and to improve techniques available to study them. Hen Egg White Lysozyme (HEWL), a model amyloid forming protein, is found to be destabilised with a complex of HS in the zinc (HS(Zn)) from 67.7 °C to 57.6 °C compared to 65.3 °C in the presence of HS in the Na form (as measured by differential scanning fluorimetry). These complexes were studied structurally using synchrotron radiation circular dichroism (SRCD) and found to contain extremely similar secondary structure. To differentiate these similar structures principal component analysis (PCA) of thermal and UV degradations of the complexes using CD were analysed. The HS and HS(Zn) ligands were hypothesised to interact with the two tryptophan residues (Trp) in the active site of HEWL. To confirm this, magnetic circular dichroism (MCD) was also developed as a technique to observe direct Trp:ligand interactions. MCD demonstrated an interaction between HS/HS(Zn) and Trp in HEWL using a signal at the novel position of 286 nm. Antithrombin (AT) was studied in relation to the active pentasaccharide drug and inactive shrimp heparinoids (SH) that contain the important 3-O-sulfate, thought to be key for AT activity against factor Xa. These active and inactive complexes were found to be structurally similar again when studied with SRCD so were subjected to UV degradation. The active and non-active compounds were finally differentiated via their induced stability in AT to thermal degradation. This important correlation challenges the current dogma, which relates activity with a particular pentasaccharide sequence. 2D generalised correlation techniques were applied to the data obtained in this thesis increasing the resolution of the data significantly, allowing for
Coherent-Classical Estimation for Linear Quantum Systems
Creators: name: Roy, Shibdas
name: Petersen, Ian R.
name: Huntington, Elanor H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Physical sciences

description: We study a coherent-classical estimation scheme for a class of linear quantum systems, where the estimator is a mixed quantum-classical system that may or may not involve coherent feedback. We show that when the quantum plant or the quantum part of the estimator (coherent controller) is an annihilation operator only system, coherent-classical estimation without coherent feedback can provide no improvement over purely-classical estimation. Otherwise, coherent-classical estimation without feedback can be better than classical-only estimation for certain homodyne detector angles, although the former is inferior to the latter for the best choice of homodyne detector angle. Moreover, we show that coherent-classical estimation with coherent feedback is no better than classical-only estimation, when both the plant and the coherent controller are annihilation operator only systems. Otherwise, coherent-classical estimation with coherent feedback can be superior to purely-classical estimation, and in this case, the former is better than the latter for the optimal choice of homodyne detector angle.
description: Minor corrections; 10 pages, 13 figures, journal version. arXiv admin note: substantial text overlap with arXiv:1403.5348
Reliable Diversity-Based Spatial Crowdsourcing by Moving Workers
Creators: name: Cheng, Peng
name: Lian, Xiang
name: Chen, Zhao
name: Fu, Rui
name: Chen, Lei
name: Han, Jinsong
name: Zhao, Jizhong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: With the rapid development of mobile devices and the crowdsourcig platforms, the spatial crowdsourcing has attracted much attention from the database community, specifically, spatial crowdsourcing refers to sending a location-based request to workers according to their positions. In this paper, we consider an important spatial crowdsourcing problem, namely reliable diversity-based spatial crowdsourcing (RDB-SC), in which spatial tasks (such as taking videos/photos of a landmark or firework shows, and checking whether or not parking spaces are available) are time-constrained, and workers are moving towards some directions. Our RDB-SC problem is to assign workers to spatial tasks such that the completion reliability and the spatial/temporal diversities of spatial tasks are maximized. We prove that the RDB-SC problem is NP-hard and intractable. Thus, we propose three effective approximation approaches, including greedy, sampling, and divide-and-conquer algorithms. In order to improve the efficiency, we also design an effective cost-model-based index, which can dynamically maintain moving workers and spatial tasks with low cost, and efficiently facilitate the retrieval of RDB-SC answers. Through extensive experiments, we demonstrate the efficiency and effectiveness of our proposed approaches over both real and synthetic data sets.
description: 16 pages
СОЧИНЕНИЕ ПО КАРТИНЕ КАК СПОСОБ РАЗВИТИЯ РЕЧЕМЫСЛИТЕЛЬНОЙ СПОСОБНОСТИ УЧАЩИХСЯ НА УРОКАХ РУССКОГО ЯЗЫКА И ЛИТЕРАТУРЫ
Creators: name: Баширова М.А.
name: Шилханова А.Н.
name: Ибрагимов М.К.
Publisher: name: Образование и право
Year: 2022
Subjects: сочинения по картине
развитие речи
методика русского языка
виды сочинений
развитие умственных способностей
коммуникативное сотрудничество.

description: Статья посвящена одному из самых распространенных и давно применяемых в школе видов сочинения. В ней подробно рассматриваются этапы работы над сочинениями по картине. Авторы приходят к выводу, что в настоящее время существует настоятельная потребность педагогов, психологов, родителей в усовершенствованных методах психолого-педагогического воздействия на формирующуюся личность ученика с целью развития интеллектуальных, коммуникативных и творческих способностей.
title: Liquidity prediction in limit order book markets
Creators: name: Dong, Keren
Publisher: name: University of Liverpool Repository
Year: 2015

description: Limit order book markets are a rich research area, not only because these markets generated huge amounts of data (at an exceedingly high rate), but also because the fine level of detail that their data enables one to explore market microstructure in unprecedented ways. Due to the large quantity and rich details of the data in such market, one has to leverage the power of computers to perform both the analysis and modeling work. This calls for both new algorithms and infrastructure to perform the computing tasks effectively and efficiently. Motivated by the questions and challenges I see there, I started my research first from a engineering perspective and then moved to a quantitative perspective. My aim was to find my way through this newly emerging area and develop a systematic approach to seek, study and solve the potential questions in it. I will graph and explain my findings and results in this thesis, hoping that they will help and inspire further research work. To discipline and guide myself with a clear goal in the long journey exploring the world of limit order book markets, I focus on liquidity modeling. I try to predict trading volume from a daily scale to intra-day distributions, with the aim to design trading algorithms to reduce transaction costs and market impact. Within a microstructure context, I try to model the self-exciting nature of trading events with both a stochastic process approach and a statistical approach. Prediction methods are proposed to help trading algorithms to react to big trade events in real time. I use two different modelling approaches. One is based on stochastic processes that have nice mathematical properties, while the other one is driven by statistics extracted directly from the data. I try to examine them in a unified and scientific way so that it is easy to compare the strengthes and weaknesses of each of them. Empirical findings are given to support the rationale behind all of the proposed algorithms.
Characterization of microfluidic human epidermal keratinocyte culture
Creators: name: O’Neill, Adrian T.
name: Monteiro-Riviere, Nancy A.
name: Walker, Glenn M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Human epidermal keratinocytes (HEK) are skin cells of primary importance in maintaining the body’s defensive barrier and are used in vitro to assess the irritation potential and toxicity of chemical compounds. Microfluidic systems hold promise for high throughput irritant and toxicity assays, but HEK growth kinetics have yet to be characterized within microscale culture chambers. This research demonstrates HEK patterning on microscale patches of Type I collagen within microfluidic channels and maintenance of these cells under constant medium perfusion for 72 h. HEK were shown to maintain 93.0%–99.6% viability at 72 h under medium perfusion ranging from 0.025–0.4 μl min−1. HEK maintained this viability while ∼100% confluent—a level not possible in 96 well plates. Microscale HEK cultures offer the ability to precisely examine the morphology, behavior and viability of individual cells which may open the door to new discoveries in toxicological screening methods and wound healing techniques.
New Experimental Method for Investigating AC-losses in Concentric HTS Power Cables
Creators: name: Elschner, Steffen
name: Demencik, Eduard
name: Douine, Bruno
name: Grilli, Francesco
name: Kudymow, Andrej
name: Stemmle, Mark
name: Strauss, Severin
name: Zermeno, Victor
name: Goldacker, Wilfried
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The optimization of a HTS cable design with respect to AC-losses is of crucial importance for the economic viability of the respective concept. However the experimental determination of AC-losses is not straightforward since for short cable samples the distribution of current among the super-conducting tapes is mainly determined by the contact resistances of the individual tapes. The resulting inhomogeneous current distribution definitely falsifies the results. To solve this experimental problem we present a new experimental technique. The setup is a 2m-long three phase concentric cable model for which, within each phase, the superconducting tapes (up to 30) are connected in series. The Cu-braid backwards conductors were assembled in a rotational symmetric cage type arrangement, such that their self fields at the cable cancel. If experimental peculiarities of this setup, as the strong inductive coupling between the phases and the suitable positioning of the voltage contact leads, are correctly taken into account, the currents can be controlled independently and the electrical properties of the cable can be measured unambiguously. In this paper preliminary results are presented. The work is part of the German government funded cable project AMPACITY (1 km / 20 kV/ 2 kA)
On Newtonian singularities in higher derivative gravity models
Creators: name: Modesto, Leonardo
name: Netto, Tibério de Paula
name: Shapiro, Ilya L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the problem of Newtonian singularity in the wide class of higher derivative gravity models, including the ones which are renormalizable and super-renormalizable at the quantum level. The simplest version of the singularity-free theory has four derivatives and is pretty well-known. We argue that in all cases of local higher-derivative theories, when the poles of the propagator are real and simple, the singularities disappear due to the cancellation of contributions from scalar and tensor massive modes.
description: Added comment about the black hole solutions in Conclusions section. Fits published version, plus some misprints corrected in formulas at the end of Sect. 3
3-D Numerical Simulations of Twisted Stacked Tape Cables
Creators: name: Krüger, Philipp A. C.
name: Zermeño, Victor M. R.
name: Takayasu, Makoto
name: Grilli, Francesco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Different magnet applications require compact high current cables. Among the proposed solutions, the Twisted Stacked Tape Cable (TSTC) is easy to manufacture and has very high tape length usage efficiency. In this kind of cables the tapes are closely packed, so that their electromagnetic interaction is very strong and determines the overall performance of the cable. Numerical models are necessary tools to precisely evaluate this interaction and to predict the cable's behavior, e.g. in terms of effective critical current and magnetization currents. For this purpose, we developed a fully three-dimensional model of a TSTC, which not only takes into account the twisted geometry of these cables, but is also able to account for the contact resistances of the current terminations. The latter can have profound influence on the way the current is partitioned among the tapes, especially on short laboratory prototypes. In this paper, we first use the numerical model to compute the critical current and the magnetization AC loss of a twisted tape, showing the differences with the case of a straight tape. Then, we use it to calculate the current distribution in a TSTC cable, comparing the results with those experimentally obtained on a cable composed of four straight stacked tapes. The results show the ability of the model to simulate twisted conductors and constitutes a first step toward the simulation of TSTC in high-field magnet applications. The presented modeling approach is not restricted to the TSTC geometry, but may be used for any cable configuration with periodical translational symmetry.
title: 'Man is a dining animal': the archaeology of the English at table, c.1750-1900
Creators: name: Gray, Marianne
Publisher: name: University of Liverpool Repository
Year: 2012

description: This study investigates the role of gender and, within that, class in changing English dining styles in the eighteenth and nineteenth centuries. The period c.1750-1900 has been chosen to cover a major period for dining change, as it is during this time that service à la Russe superseded service à la Française as the dominant formal dining style. This change has been much discussed by food historians and sociologists, but the materiality of change has not hitherto been placed within an archaeologically-informed framework. Equally, while the artefacts of dining are among the most frequently recorded finds in domestic contexts in the historical period, archaeologists have rarely considered them in the context of long-term dining development. Drawing on data from country houses, collections, and published material on middle class and elite settings, this thesis investigates the hypothesis that dining change was driven by women, specifically middle class wives; and that dining-related ephemera must therefore be understood in its relationship with women. It also proposes a narrative of stylistic change using historical archaeological paradigms, introducing the concept of a third, clearly identifiable stage between à la Française and à la Russe. After introducing the data sets and giving a background to dining in the historical period, the first part of the study uses table plans and etiquette, together with depictions of dishes, food moulds and experimental archaeology in the form of historic cookery, to demonstrate the way in which the process of change was driven by middle class women. It argues that à la Russe suited gender and class-specific needs and that, far from being emulative, as has hitherto been assumed, the adaption of à la Russe broke with aristocratic habits. It proposes that a transitional stage in dining style should be recognised, and interprets food design and serving style in the light of this intermediate phase. The setting of dining is explored next, with data on dining décor, plates and physical location interpreted to support the conclusions of the previous section. Following this, the impact of change on food preparation will be used to demonstrate that à la Russe was the result of changes in underlying mentalities which also affected household structure and organisation. The ways women used the materiality of food, including cookbooks, to negotiate status will be demonstrated. A final section will broaden the discussion of gender, class and food. Tea has been chosen as a case study for the further testing of the conclusions drawn from the study of dinner for two reasons: firstly it was, from its introduction, immediately associated with women; and, secondly, tea-related artefacts are among the commonest of archaeological finds, but are rarely understood as engendered and active objects in a domestic context.
title: An experimental study of particle sizing in static condition and in shear flow by diffusing-wave spectroscopy
Creators: name: Huang, Huan
Publisher: name: University of Liverpool Repository
Year: 2013

description: This thesis focuses on the micro/nanoparticle size measurement by using Diffusing-wave Spectroscopy, investigating the laser power and concentration effect on the measurement and researching the measuring method for particles in shear flow. A DWS-CCD backscattering experiment set-up was used in this project. By using this set-up, in all about 2000 experiments were performed during the project, including system testing, laser power influence study, concentration effect study and shear flow study. In the beginning, a detailed analysis of the particle sizing for particles in static condition was carried out by summarising the principles and procedures. The results revealed that the experimental set-up in this work was reliable and repeatable. A calibration process was still required for the CCD’s frame rate and resolution, the light absorption and the CCD’s position in the set-up. After determining some important parameters, the research was extended to laser power and concentration influence study. The autocorrelation functions were produced under different laser power and for different concentration of particle solution. Analysis confirmed the influences, and the results were expressed in formulas to describe specific effects for laser power and solution concentration. Based on the formulas, new equations for particle sizing were derived for different concentration ranges. After that, particle’s motion and light scattering in shear flow were investigated. It was concluded that three regions could be used to describe the particle’s movement under shear force; in different regions, the autocorrelation functions were different due to the variation of the characteristic time scales. The Brownian motion and shear strain dominated particle’s movement under specific flow velocities. Therefore, for particles subjected to high flow velocities, a new particle sizing formula was produced to distinguish the general formula which was only valid for particles under Brownian motion. Contributions made by this research are applying DWS application to micro/nanoparticle sizing in different conditions. In static condition, the laser power and concentration influence were described in formulas; new equations were produced for particle sizing for different concentration range. In shear flow, the thresholds of Brownian motion domination and shear flow domination were found; a new particle sizing equation was derived for particles only controlled by shear force.
A High Efficiency MAC Protocol for WLANs: Providing Fairness in Dense Scenarios
Creators: name: Sanabria-Russo, Luis
name: Barcelo, Jaume
name: Bellalta, Boris
name: Gringoli, Francesco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Collisions are a main cause of throughput degradation in WLANs. The current contention mechanism used in IEEE 802.11 networks is called Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA). It uses a Binary Exponential Backoff (BEB) technique to randomise each contender attempt of transmitting, effectively reducing the collision probability. Nevertheless, CSMA/CA relies on a random backoff that while effective and fully decentralised, in principle is unable to completely eliminate collisions, therefore degrading the network throughput as more contenders attempt to share the channel. To overcome these situations, Carrier Sense Multiple Access with Enhanced Collision Avoidance (CSMA/ECA) is able to create a collision-free schedule in a fully decentralised manner using a deterministic backoff after successful transmissions. Hysteresis and Fair Share are two extensions of CSMA/ECA to support a large number of contenders in a collision-free schedule. CSMA/ECA offers better throughput than CSMA/CA and short-term throughput fairness. This work describes CSMA/ECA and its extensions. Additionally, it provides the first evaluation results of CSMA/ECA with non-saturated traffic, channel errors, and its performance when coexisting with CSMA/CA nodes. Furthermore, it describes the effects of imperfect clocks over CSMA/ECA and present a mechanism to leverage the impact of channel errors and the addition/withdrawal of nodes over collision-free schedules. Finally, experimental results on throughput and lost frames from a CSMA/ECA implementation using commercial hardware and open-source firmware are presented.
description: This work has been submitted to the IEEE/ACM Transactions on Networking journal
CGDSNPdb: a database resource for error-checked and imputed mouse SNPs
Creators: name: Churchill, G. A.
name: Hutchins, L. N.
name: Smith, R. V.
name: Ding, Y.
name: de Villena, F. P.-M.
name: Szatkiewicz, J. P.
name: Yang, H.
name: Graber, J. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The Center for Genome Dynamics Single Nucleotide Polymorphism Database (CGDSNPdb) is an open-source value-added database with more than nine million mouse single nucleotide polymorphisms (SNPs), drawn from multiple sources, with genotypes assigned to multiple inbred strains of laboratory mice. All SNPs are checked for accuracy and annotated for properties specific to the SNP as well as those implied by changes to overlapping protein-coding genes. CGDSNPdb serves as the primary interface to two unique data sets, the ‘imputed genotype resource’ in which a Hidden Markov Model was used to assess local haplotypes and the most probable base assignment at several million genomic loci in tens of strains of mice, and the Affymetrix Mouse Diversity Genotyping Array, a high density microarray with over 600 000 SNPs and over 900 000 invariant genomic probes. CGDSNPdb is accessible online through either a web-based query tool or a MySQL public login.
title: Strategic communication in Spanish as L2: exploring the effects of proficiency, task and interlocutor
Creators: name: Rosas Maldonado, Maritza
Publisher: name: University of Liverpool Repository
Year: 2013

description: This thesis investigates the way English L2 learners of Spanish communicate face-to-face with other learners (NNS), and native speakers (NS) by means of communication strategies (CSs). The final aim is to examine the learners’ strategic use of the target language as influenced by three variables: the proficiency level, the type of task and the type of dyad. Learners with different proficiency levels interacted face-to-face when carrying out two types of tasks. 36 interactions with different combinations of dyad and task were elicited by means of video and audio recording, observation of participants’ interactions and stimulated recall methodology. Quantitative and qualitative analyses were conducted to investigate possible associations between CSs and tasks, dyads and proficiency levels in each setting. The major findings in this study indicate a higher use of CSs in beginner levels, which was reflected in the lower level learners’ concern for solving lexis-related problems, and their tendency to focus on less complex grammatical features of the language. The higher level learners, however, seemed to focus more on grammar-related problems, as well as on more complex aspects of the target language. A similar lexis-grammar distinction was observed for the task variable. The open task, a free-conversation activity, involved higher cognitive demands due to the lack of visual support and the linguistic freedom provided by the topics given. This pushed the learners to invest more in the conversation, by attempting to produce more L2 and more conceptually complex ideas, thus making it a more grammar-oriented activity. Conversely, the closed task, a jigsaw activity, resulted in a more linguistically demanding task due to its linguistic restrictions, through the visual context provided, posing more lexis-related problems. Finally, the NNS-NS’s non-shared status was the major influence on the learners’ CSs. The NS – through their linguistic expertise – did not only assist and guide the learners, when this help was elicited through the learners’ CSs, but also triggered comprehension problems because of their more complex speech. The NNSs’ similar status, on the other hand, although also triggered the learners’ appeal for help – albeit to a lesser extent – the interlocutor was less likely to provide the assistance required, and just acknowledged their peer’s message to avoid a communication breakdown and maintain the conversation. It seemed that the learners do not expect this assistance as much as when interacting with a NS, as they are aware of their mutual lack of L2 resources, and because their shared characteristics also promote a mutual, implicit understanding between them.
СТАБИЛЬНОСТЬ ГОСУДАРСТВА В КОНТЕКСТЕ СООТНОШЕНИЯ АВТОРИТАРНОГО И ДЕМОКРАТИЧЕСКОГО НАЧАЛ
Creators: name: Чемшит А.А.
Publisher: name: Образование и право
Year: 2022
Subjects: авторитаризм
демократизм
государство
политическая система
правовая система
политический процесс
права и свободы.

description: . В центр внимания статьи вынесена идея поиска оптимального соотношения авторитаризма и демократизма в поддержании стабильности государства и политической системы в целом. В исследовании применён системный метод, обеспечивающий рассмотрение институтов государственной власти и гражданского общества через призму их места и роли в изменяющейся политической системе. Акцентируется внимание на правовой системе как важнейшей структуре системы политической. Отмечается, что взаимодействие элементов правовой системы (процессуальный уровень) определяется моделью государственного строя (Конституцией государства), которая в свою очередь строится на основе соответствующей социально-философской концепции (концептуальный уровень). Обосновывается вывод, что стабильность государства и всей социальной системы сохраняется в том случае если её централизация (авторитаризм) обеспечивается 80% национальных ресурсов. Оставшаяся часть составляет ресурсную базу обеспечения демократических прав и свобод.
СУДЕБНОЕ ПРАВОТВОРЧЕСТВО, РЕАЛИЗУЕМОЕ ПОСРЕДСТВОМ ПРИМЕНЕНИЯ АНАЛОГИИ ЗАКОНА И АНАЛОГИИ ПРАВА
Creators: name: Межеккей А.В.
Publisher: name: Образование и право
Year: 2022
Subjects: судебное правотворчество
аналогия закона
аналогия права
восполнение пробелов правового регулирования.

description: В статье рассматриваются такие способы судебного правотворчества как аналогия закона и аналогия права, применяемые судом при осуществлении гражданского судопроизводства, а также правосудия в сфере предпринимательской и иной экономической деятельности для восполнения пробелов в правовом регулировании. Рассматриваются примеры из судебной практики как обоснованного, так и необоснованного применения судами аналогии закона, а также сам механизм судебного правотворчества при применении судом аналогии закона. Помимо применения судом аналогии гражданского закона при осуществлении гражданского судопроизводства, а также правосудия в сфере предпринимательской и иной экономической деятельности, рассматривается применение судом аналогии гражданского закона при осуществлении правосудия по уголовным делам. Далее рассматривается пример судебного правотворчества при применении аналогии права, а также механизм судебного правотворчества при применении аналогии права. Автором сделаны следующие выводы. Если пробел в правовом регулировании, послуживший поводом для применения судом аналогии закона или аналогии права в последующем не устранен законодателем, следующее судебное разбирательство по делу со схожими обстоятельствами, весьма вероятно, также закончится применением аналогии закона или аналогии права. То есть суд, применяя аналогию закона и аналогию права, совершает правотворчество не только в данном конкретном деле, но и создает предпосылку для правотворчества в будущих судебных разбирательствах. Законодатель, в свою очередь, не только допускает возможность судебного правотворчества в форме применения аналогии закона и аналогии права, но и осознает ее необходимость, вызванную объективной невозможностью создать беспробельное законодательство.
An overview of the BioCreative 2012 Workshop Track III: interactive text mining task
Creators: name: Chatr-aryamontri, A.
name: Li, Y.
name: Roberts, P.
name: Jimenez, S.
name: Wilbur, W. J.
name: Van Slyke, C. E.
name: Licata, L.
name: Park, J.
name: Haendel, M.
name: Mabee, P.
name: Drabkin, H.
name: Matthews, L.
name: Balhoff, J. P.
name: Carterette, B.
name: Arighi, C. N.
name: Cohen, K. B.
name: Li, D.
name: Cui, H.
name: Becker, K.
name: Fey, P.
name: Chi-Yang Wu, J.
name: Van Auken, K.
name: Bello, S.
name: Gillespie, M.
name: Schaeffer, M. L.
name: Chan, J.
name: Dahdul, W.
name: Muller, H.-M.
name: Cooper, L.
name: Harris, B.
name: Krallinger, M.
name: Dodson, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In many databases, biocuration primarily involves literature curation, which usually involves retrieving relevant articles, extracting information that will translate into annotations and identifying new incoming literature. As the volume of biological literature increases, the use of text mining to assist in biocuration becomes increasingly relevant. A number of groups have developed tools for text mining from a computer science/linguistics perspective, and there are many initiatives to curate some aspect of biology from the literature. Some biocuration efforts already make use of a text mining tool, but there have not been many broad-based systematic efforts to study which aspects of a text mining tool contribute to its usefulness for a curation task. Here, we report on an effort to bring together text mining tool developers and database biocurators to test the utility and usability of tools. Six text mining systems presenting diverse biocuration tasks participated in a formal evaluation, and appropriate biocurators were recruited for testing. The performance results from this evaluation indicate that some of the systems were able to improve efficiency of curation by speeding up the curation task significantly (∼1.7- to 2.5-fold) over manual curation. In addition, some of the systems were able to improve annotation accuracy when compared with the performance on the manually curated set. In terms of inter-annotator agreement, the factors that contributed to significant differences for some of the systems included the expertise of the biocurator on the given curation task, the inherent difficulty of the curation and attention to annotation guidelines. After the task, annotators were asked to complete a survey to help identify strengths and weaknesses of the various systems. The analysis of this survey highlights how important task completion is to the biocurators’ overall experience of a system, regardless of the system’s high score on design, learnability and usability. In addition, strategies to refine the annotation guidelines and systems documentation, to adapt the tools to the needs and query types the end user might have and to evaluate performance in terms of efficiency, user interface, result export and traditional evaluation metrics have been analyzed during this task. This analysis will help to plan for a more intense study in BioCreative IV.
The mechanism of long-term coarsening of granular mixtures in rotating drums
Creators: name: Finger, Tilo
name: Schröter, Matthias
name: Stannarius, Ralf
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Three fundamental segregation and pattern formation processes are known in granular mixtures in a rotating cylindrical drum: radial segregation, axial banding, and coarsening of the band pattern. While the mechanism for the first effect is well understood and for the second effect, several models have been proposed, the long-term coarsening mechanism remained unexplained so far. We demonstrate that the unidirectional flow between the bands in an axially segregated pattern is driven by small differences in size of the small beads at the band edges. Due to a process of microsegregation inside each band of small particles, which was so far unrecognized, this difference in diameter will be effective in all experiments with polydisperse beads. In consequence the stability of individual bands can be easily controlled by minor alterations of their composition. Our results make evident that a new mechanism as the driving force behind the axial particle flow has to be sought. We suggest possible hypotheses for such a mechanism.
СУДЕБНЫЕ МЕХАНИЗМЫ УРЕГУЛИРОВАНИЯ СПОРОВ, ВОЗНИКАЮЩИХ В ОБЛАСТИ СПОРТА: НАЦИОНАЛЬНЫЙ И МЕЖДУНАРОДНЫЙ АСПЕКТ
Creators: name: Янишевская Я.А.
Publisher: name: Образование и право
Year: 2022
Subjects: спорт
международный спортивный арбитражный суд
третейский суд
спортивный спор
спортсмен.

description: В современном мире принята практика использования специализированных третейских судов при решении спортивных споров, поскольку это позволяет сочетать наличие необходимых знаний в области спорта, независимость и оперативность функционирования с обязательностью решений. В статье автор анализирует национальные и международные судебные правовые механизмы разрешения спортивные споры.
D7.2: Dissemination and Communication Plan update 1
Creators: name: Ntina, Georgia
name: Sargent, David
name: Mavromanolaki, Eirini
name: Vliora, Maria
name: Moreira, Rosa
name: Pinto, Maria
name: Landers, Fabian
name: Stivaktakis, Polychronis
name: Vidal, Salvador
Publisher: name: Zenodo
Year: 2024
Subjects: Dissemination; communication;

description: The Dissemination and Communications Plan provides the ANGIE project with a solid framework, roadmap, and practical tools to help disseminate project results and activities. This report provides the details of the efforts taken and the results at the halfway point of the ANGIE project. The report describes the efforts undertaken to publicize the goals and results of the ANGIE project to target audiences so far: specifically, this involves the setting up of the ANGIE website, social media accounts, workshops and conferences that have been organized, scientific publications, and conference presentations.