cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Moderated Online Social Therapy to Treat Social Anxiety in First-Episode Psychosis
Creators: name: McEnery, Carla
Publisher: name: Swinburne
Year: 2024

description: The overarching aim of this thesis was to: 1) examine the prevalence of social anxiety in psychosis and its psychosocial outcomes in order to provide clinicians and the research community with a reliable estimate of current prevalence and specific treatment considerations, 2) to develop a world-first, innovative and engaging moderated online Cognitive-behavioural-therapy based intervention to treat social anxiety as a primary treatment concern in young people with first-episode psychosis and 3) to test the feasibility, acceptability, safety and preliminary effectiveness of the moderated online social intervention in order to inform future research.
Supporting Information for the research article  - "Machine Learning Accelerated Interfacial Fluxionality in Ni-supported Metal Nitride Ammonia Synthesis Catalysts"
Creators: name: Roy, Pranav
name: Bukowski, Brandon
Publisher: name: Zenodo
Year: 2025

description: This zip contains :

Input files for DFT/AIMD/LAMMPS/NequIP runs

Structural files for the Free Energy Profile and the H-coverage models

Trajectory for the H-coverage and Size extensivity models with checkpoints

Trained machine learning interatomic potentials

Supplementary movies for the MLMD runs
Supporting Information for the research article  - "Machine Learning Accelerated Interfacial Fluxionality in Ni-supported Metal Nitride Ammonia Synthesis Catalysts"
Creators: name: Roy, Pranav
name: Bukowski, Brandon
Publisher: name: Zenodo
Year: 2025

description: This zip contains the input files for DFT/AIMD/LAMMPS/NequIP runs as well as the transition state structures.
Inclusive assessment @NWO
Creators: name: Hergaarden, Carry
Publisher: name: Zenodo
Year: 2021
Subjects: gender equality
superah2020

description: Presentation held by Carry Hergaarden (The Dutch Research Council - NWO) during the webinar "A closer look to unconscious bias and what RFOs can do", organised by SUPERA on 16 December 2021.
Electronic supplementary material from Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro
Creators: name: Stahnke, Thomas
name: Gajda-Deryło, Beata
name: Jünemann, Anselm G.
name: Stachs, Oliver
name: Sterenczak, Katharina A.
name: Rejdak, Robert
name: Beck, Julia
name: Schütz, Ekkehard
name: Möller, Steffen
name: Barrantes, Israel
name: Warsow, Gregor
name: Struckmann, Stephan
name: Fuellen, Georg
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Cell Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: To elucidate and to inhibit post-surgical fibrotic processes after trabeculectomy in glaucoma therapy, we measured gene expression in a fibrotic cell culture model, based on transforming growth factor TGF-β induction in primary human tenon fibroblasts (hTFs), and used Connectivity Map (CMap) data for drug repositioning. We found that specific molecular mechanisms behind fibrosis are the upregulation of actins, the downregulation of CD34, and the upregulation of inflammatory cytokines such as IL6, IL11 and BMP6. The macrolide antibiotic Josamycin (JM) reverses these molecular mechanisms according to data from the CMap, and we thus tested JM as an inhibitor of fibrosis. JM was first tested for its toxic effects on hTFs, where it showed no influence on cell viability, but inhibited hTF proliferation in a concentration-dependent manner. We then demonstrated that JM suppresses the synthesis of extracellular matrix (ECM) components. In hTFs stimulated with TGF-β1, JM specifically inhibited α-smooth muslce actin expression, suggesting that it inhibits the transformation of fibroblasts into fibrotic myofibroblasts. In addition, a decrease of components of the ECM such as fibronectin, which is involved in in vivo scarring, was observed. We conclude that JM may be a promising candidate for the treatment of fibrosis after glaucoma filtration surgery or drainage device implantation in vivo.
BioExcel Webinar #48 - Computational biomolecular simulation workflows with BioExcel building blocksB
Creators: name: Hospital, Adam
Publisher: name: Zenodo
Year: 2020
Subjects: Webinar

description: Are you interested in computational biomolecular simulation methods such as molecular dynamics, docking, and free energy calculations, but hesitant to take the first step? What if you could start smoothly using an interactive, graphical user interface like a Jupyter Notebook? What if you could easily build pipelines that chain together different programs using a single, interoperable library and a single syntax? Join this webinar session, where we will introduce the BioExcel Building Blocks (BioBB), a fully interoperable software library comprising a collection of Python wrappers on top of biomolecular simulation tools such as GROMACS, AmberTools, Open Babel and ACPYPE. The philosophy behind its design follows best practices and FAIR principles for software development, making BioBB easy to find, install, and use and facilitating reproducibility and reusability. The webinar will introduce demonstration workflows implemented in Jupyter notebooks using the BioBB library (e.g. protein MD simulation setup with GROMACS), and briefly present the first steps involved in building and running complex workflows using the command line, with examples of workflows tackling real scientific problems.
description: Webinar link: https://www.youtube.com/watch?v=zVMygrtojbI
Measurement of carbon monoxide pressure broadening and temperature dependence coefficients in the 1←0 band
Creators: name: Zhu, Denghao
name: Seifert, Leopold
name: Agarwal, Sumit
name: Shu, Bo
name: Fernande, Ravi
name: Qu, Zhechao
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2025
Subjects: CO
TDLAS
line parameters
gas sensing

description: Two laser absorption spectroscopy (LAS)-based spectrometers have been developed for measuring carbon monoxide (CO) pressure broadening and temperature dependency coefficients in the 1←0 band. Using a scanned-wavelength LAS at 140 Hz, pressure broadening coefficients of four CO transition lines P(16), P(20), P(26), and P(27), perturbed by Ar, He, H₂, O₂, N₂, CO₂, and Air have been systematically measured in a gas cell using a consistent metrological approach. Results indicate that the CO pressure broadening coefficient decreases monotonically as the line number |m| increases. The variation of pressure broadening coefficients at different buffer gases follow a consistent trend for all four measured lines: CO-H2 and CO-Ar show the highest and lowest pressure broadening coefficients, respectively. Compared to the literature results with relatively large uncertainties or even unavaible uncertainty information, the uncertainty of measured pressure broadening coefficients is below 1% for most cases. Further, using a scanned-wavelength LAS at 20 kHz, temperature dependence coefficients of P(20) in Ar, He, N₂ and CO₂ were measured at a temperature range of 430-1648 K in a shock tube. With this rapid scan frequency, the spectrum between incident shock and reflected shock was also used for temperature dependence coefficient calculation. The uncertainty of the measured temperature dependence coefficients are under 6.2%. Toward combustion systems as an application case, the CO mole fraction during CH4 oxidation in the shock tube was quantified using a fixed-wavelength LAS. The results reveal that the uncertainty in CO mole fraction was reduced by a factor of 2.7 when using the line parameters obtained in this study compared to those from the HITRAN database. Thus, the newly measured data with low uncertainties substantially enhance the spectroscopic database, enabling more precise CO mole fraction quantification across a range of application scenarios such as environmental monitoring, industrial control, safety monitoring, medicine, astronomy, and scientific research.
title: Power Simulation of a MIPS microAptiv UP Core implemented as a virtual ASIC prototype in a 65nm CMOS technology
Creators: name: Shi, Yanchen
Publisher: name: Fachhochschule Dortmund
Year: 2022
Subjects: subject: 620 Ingenieurwissenschaften und Maschinenbau

description: This thesis presents a power simulation of a MIPS MicroAptiv UP Core implemented as a virtual ASIC prototype using Taiwan Semiconductor Manufacturing Company(TSMC) 65 nm CMOS technology. Based on the MIPS instruction set program data is generated and introduced in the simulation by means of initialization files. Before the simulation, technology specific SRAM modules are integrated into theMIPS core. Two different programs are used for power characterization. The first program performs frequent memory accesses by means of load/store word instructions, while the second program is a loop which operates on registers only and mainly increments addresses. The simulation is based on a virtual prototype which is generated by synthesis and place & route including post-layout parasitic extractions. The stimuli for the power extraction is generated via gate-level simulation and forwarded to the power calculation engine. The effect of X-propagation on gate-level simulations is avoided by modifying the address-related statements in the execution data path module, which use another form of 2 to 1 multiplexer, setting the output to zero for all input signals even with an initial value of ’x’ without changing the functionality. Finally, the consumed power is provided by reports generated by the power simulation engine. The memory-centric program consumes 35.39mW of internal power using instructions, which is 0.73mW less than the internal power of the register-centric program, and the overall average power is also lower by almost 0.7mW.
The value of integrating design processes in action in technology driven product development
Creators: name: Graham, Alexander
Publisher: name: Swinburne
Year: 2024

description: Scientists and technology developers have been slow to introduce design into the early stages of technology driven product development because they do not understand the value that designers can contribute to applying their research.
This thesis contributes to our understanding of the barriers to effective collaboration in technology driven product development, and how Design Thinking approaches to co-design can be used to overcome them. Significantly, this thesis uses the theory and metaphor of a Black Box to ground the early integration of design in action within technology driven product development, and codifies the outcomes of the research in a framework for practitioners.
Costs of colorectal cancer screening with colonoscopy, including post-endoscopy events, among adults with Medicaid insurance
Creators: name: Fisher, Deborah A.
name: Princic, Nicole
name: Miller-Wilson, Lesley-Ann
name: Wilson, Kathleen
name: Limburg, Paul
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: To examine the healthcare utilization and costs associated with colorectal cancer (CRC) screening by colonoscopy, including costs associated with post-endoscopy events, among average-risk adults covered by Medicaid insurance. This cohort study evaluated a population of adults (ages 50–75 years) with CRC screening between 1/1/2014 and 12/31/2018 (index = earliest test) from the IBM MarketScan Multi-State Medicaid database. Individuals at above-average risk for CRC or with prior CRC screening were excluded. CRC screening was reported by screening type: colonoscopy, fecal immunochemical test [FIT], fecal occult blood test [FOBT], multi-target stool DNA [mt-sDNA]. Frequency and costs of events potentially related to colonoscopy (defined as occurring within 30 days post-endoscopy) were reported overall, by event type, and by individual event. We identified a total of 13,134 average-risk adults covered by Medicaid insurance who received screening by colonoscopy; 63.6% (8350) had Medicare dual-eligibility while 36.4% (4785) did not have Medicare dual-eligibility. The mean (SD) cost of a colonoscopy procedure was $684 ($907) and mean (SD) out-of-pocket costs were $6 ($132). Serious gastrointestinal (GI) events (perforation and bleeding) were observed in 4.6% of individuals with colonoscopy, 4.3% had other GI events, and 3.0% had an incident cardiovascular/cerebrovascular event. Mean (SD) event-related costs were $1233 ($5784) among individuals with a serious GI event, $747 ($1961) among individuals with other GI events, and $4398 ($19,369) among individuals with a cardiovascular/cerebrovascular event. This large, claims-based cohort study reports average (SD) out-of-pocket costs for Medicaid beneficiaries at $6 ($132), which could be one factor contributing to the accessibility of CRC screening by colonoscopy. The incidence of events potentially associated with colonoscopy (i.e. within 30 days after the screening) was 3–4%, and the event-related costs were considerable.
Expectations and educational needs of rheumatologists, rheumatology fellows and patients in the field of precision medicine in Canada, a quantitative cross-sectional and descriptive study
Creators: name: Ruel-Gagné, Sophie
name: Simonyan, David
name: Légaré, Jean
name: Bessette, Louis
name: Fortin, Paul R.
name: Lacaille, Diane
name: Dogba, Maman J.
name: Michou, Laëtitia
Publisher: name: BioMed Central
Year: 2021

description: Background Precision medicine, as a personalized medicine approach based on biomarkers, is a booming field. In general, physicians and patients have a positive attitude toward precision medicine, but their knowledge and experience are limited. In this study, we aimed at assessing the expectations and educational needs for precision medicine among rheumatologists, rheumatology fellows and patients with rheumatic diseases in Canada. Methods We conducted two anonymous online surveys between June and August 2018, one with rheumatologists and fellows and one with patients assessing precision medicine expectations and educational needs. Descriptive statistics were performed. Results 45 rheumatologists, 6 fellows and 277 patients answered the survey. 78% of rheumatologists and fellows and 97.1% of patients would like to receive training on precision medicine. Most rheumatologists and fellows agreed that precision medicine tests are relevant to medical practice (73.5%) with benefits such as helping to determine prognosis (58.9%), diagnosis (79.4%) and avoid treatment toxicity (61.8%). They are less convinced of their usefulness in helping to choose the most effective treatment and to improve patient adherence (23.5%). Most patients were eager to take precision medicine tests that could predict disease prognosis (92.4%), treatment response (98.1%) or drug toxicity (93.4%), but they feared potential negative impacts like loss of insurability (62.2%) and high cost of the test (57.5%). Conclusions Our study showed that rheumatologists and patients in Canada are overall interested in getting additional precision medicine education. Indeed, while convinced of the potential benefits of precision medicine tests, most physicians don’t feel confident in their abilities and consider their training insufficient to incorporate them into clinical practice.
Calibration of cascaded phase shifters using pairwise scan method in silicon photonics integrated chip
Creators: name: Jia, Yanxiang
name: Wang, Xuyang
name: Hou, Yizhuo
name: Zhang, Yu
name: Shi, Yuqi
name: Zhang, Qiang
name: Zou, Jun
name: Li, Yongmin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Cascaded phase shifters (CPSs) based on silicon photonics integrated chips play important roles in quantum information processing tasks. Owing to an increase in the scale of silicon photonics chips, the time required to calibrate various CPSs has increased. We propose a pairwise scan method for rapidly calibrating CPSs by introducing equivalent Mach Zehnder Interferometer structures and a reasonable constraint of the initial relative phase. The calibration can be nearly completed when the scanning process is finished, and only a little calculation is required. To achieve better performance, the key components, thermal optical phase shifter and 2 * 2 50/50 multimode interference coupler, were simulated and optimized to prevent thermal crosstalk and ensure a good balance. A 6-CPSs structure in a packaged silicon photonics chip under different temperature was used to verify the rapid pairwise scan method, and a fidelity of 99.97% was achieved.
Primary care costs due to prodromal Alzheimer disease: a real-world study in patients with a 10-year or longer medical history
Creators: name: Vetrano, Davide L.
name: Grande, Giulia
name: Mazzoleni, Francesco
name: Lovato, Valeria
name: Cricelli, Claudio
name: Lapi, Francesco
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The aim of this study was to estimate primary care costs of prodromal signs/symptoms of Alzheimer disease (AD), during a 10-year or longer period preceding AD diagnosis, in relation to costs cumulated in the general population for the same reasons. Nested case-control study involving 1889 AD cases and 18,890 controls aged 60+ from the Italian primary care Health Search Database (HSD). AD incident cases were through the International Classification of Diseases, 9th edition. Costs related to drugs, diagnostic tests and specialist referrals triggered by prodromal AD signs and/or symptoms were quantified and compared with costs cumulated by non-AD counterparts. During the pre-diagnosis 10-year or longer period, prodromal signs and symptoms trigger diagnostic and therapeutic costs 55% higher than those cumulated in general population for the same clinical reasons. After accounting for patients’ comorbidity and regional differences, the mean cost related to diagnostic and therapeutic procedures, and those related to specialist referrals, amounted to 854.1 €(SD: 630.6 €) in AD incident cases vs. 527.3 €(SD: 446.2) cumulated in patients not developing AD. Prodromal AD manifestations are associated with primary care costs that resulted higher than those cumulated in the general population aged 60+. It remains to be elucidated if earlier dementia diagnoses would be associated with reduced costs triggered by the same clinical signs and symptoms.
title: Front Matter, Table of Contents, Preface, Conference Organization
Creators: name: Královič, Rastislav
name: Kučera, Antonín
Publisher: name: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
Year: 2024
Subjects: subject: Front Matter
subject: Table of Contents
subject: Preface
subject: Conference Organization
subject: Theory of computation
subject: Mathematics of computing

description: Front Matter, Table of Contents, Preface, Conference Organization
description: LIPIcs, Vol. 306, 49th International Symposium on Mathematical Foundations of Computer Science (MFCS 2024), pages 0:i-0:xviii
Energy Scalability Limits of Dissipative Solitons
Creators: name: Kalashnikov, Vladimir L.
name: Rudenkov, Alexander
name: Sorokin, Evgeni
name: Sorokina, Irina T.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: In this study, we apply a thermodynamical approach to elucidate the primary constraints on the energy scaling of dissipative solitons (DS). We rely on the adiabatic theory of strongly chirped DS and define the DS energy scaling in terms of dissipative soliton resonance (DSR). Three main experimentally verifiable signatures identify a transition to DSR: i) growth of a Lorentzian spike at the centrum of the DS spectrum, which resembles a spectral condensation in Bose-Einstein condensate (BEC), ii) saturation of the spectrum broadening, and iii) asymptotical DS stretching. We connect the DSR breakup with three critical factors: i) decoupling of two correlation scales inherent in strongly chirped DS, ii) resulting rise of the DS entropy with energy, which provokes its disintegration, and iii) transition to a nonequilibrium phase, which is characterized by negative temperature. The breakup results in multiple stable DSs with lower energy. Theoretical results are in good qualitative agreement with the experimental data from a Kerr-lens mode-locked Cr$^{2+}$:ZnS chirped-pulse oscillator (CPO) that paves the way for optimizing high-energy femtosecond pulse generation in solid-state CPO and all-normal-dispersion fiber lasers.
description: 16 pages, 13 figures
ZAMONAVIY SANOAT ROBOTLARI VA ULARNING TURLARI
Creators: name: A'zamov, Og'abek
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada zamonaviy sanoat robotlarining ishlab chiqarish jarayonidagi o‘rni, ularning asosiy vazifalari va amaliy qo‘llanilishi yoritilgan. Shuningdek, sanoat robotlarining klassifikatsiyasi, ya’ni manipulyator robotlar, mobil robotlar, ko‘p funksiyali avtomatlashtirilgan tizimlar kabi turlari haqida ma’lumotlar berilgan. Har bir turga xos texnik xususiyatlar, ularning afzalliklari hamda ishlab chiqarish samaradorligiga ta’siri tahlil qilingan.
Improving Plot-Level Model of Forest Biomass: A Combined Approach Using Machine Learning with Spatial Statistics
Creators: name: Dai, Shaoqing
name: Zheng, Xiaoman
name: Gao, Lei
name: Xu, Chengdong
name: Zuo, Shudi
name: Chen, Qi
name: Wei, Xiaohua
name: Ren, Yin
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Estimating the aboveground biomass (AGB) at the plot level plays a major role in connecting accurate single-tree AGB measurements to relatively difficult regional AGB estimates. However, AGB estimates at the plot level suffer from many uncertainties. The goal of this study is to determine whether combining machine learning with spatial statistics reduces the uncertainty of plot-level AGB estimates. To illustrate this issue, this study evaluates and compares the performance of different models for estimating plot-level forest AGB. These models include three different machine learning models [support vector machine (SVM), random forest (RF), and a radial basis function artificial neural network (RBF-ANN)], one spatial statistic model (P-BSHADE), and three combinations thereof (SVM & P-BSHADE, RF & P-BSHADE, and RBF-ANN & P-BSHADE). The results show that the root mean square error, mean absolute error, and mean relative error of all combined models are substantially smaller than those of any individual model, with the RF & P-BSHADE combined method generating the smallest values. These results indicate that a combined approach using machine learning with spatial statistics, especially the RF & P-BSHADE model, improves the accuracy of plot-level AGB models. These research results contribute to the development of accurate large-forested-landscape AGB maps.
BOSHLANG'ICH SINF O'QUVCHILARIDA CHIROYLI YOZUV MALAKALARINI SHAKLLANTIRISHNING SAMARALI USULLARI
Creators: name: Toshpulatova Laylo Shamsiddin qizi Xudoyqulova Nilufar Rahimqul qizi    Saniginova Sevinch Bunyoq qizi Xayrullayeva Baxtiniso O`ral qii Safarova Rushana Murodullo qizi Denov tadbirkorlik va pedagogika instituti Pedagogika fakulteti Boshlang`ich  ta`lim yo`nalishi talabalari
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada boshlang‘ich sinf o‘quvchilarida chiroyli yozuv malakalarini shakllantirishning samarali usullari yoritilgan. Chiroyli yozuv bola tafakkuri, estetik didi, mantiqiy fikrlash salohiyati va intizomini rivojlantirishda muhim omil hisoblanadi. Tadqiqot davomida yozuv malakasini shakllantirishda individual yondashuv, grafik mashqlar, ko‘rgazmali vositalardan foydalanish va o‘yin texnologiyalarining o‘rni tahlil qilinadi. Muallif ta’limda ilg‘or pedagogik texnologiyalar asosida o‘quvchilarda yozuv madaniyatini rivojlantirish bo‘yicha tavsiyalarni ilgari suradi.

       Kalit so‘zlar: chiroyli yozuv, boshlang‘ich sinf, grafik malaka, pedagogik texnologiya, yozuv madaniyati
Impactmessung 2.0
Creators: name: Bornschein, Mathias
Publisher: name: My University
Year: 2015
Subjects: Bewertung

description: Wissenschaft und Karriere sind heute eng mit Evaluierungverbunden. Impact, Journal Impact Factor(JIF) oder Hirschfaktor (h-Index) sind dabei dieWährung, mit der in der heutigen Wissenschaftsweltgezahlt wird. Dabei erfordern wissenschaftlicherErfolg und Reputation seit jeher viel Beachtung.ůPublish or perish - veröffentliche oder geheunterś, eine im Wissenschaftsbetrieb gängige Redewendungzeigt, dass Wissenschaftlerinnen undWissenschaftler in der Vergangenheit und heute zunehmenddanach bewertet werden, wo und wie vielsie publiziert haben und publizieren. Artikel in denTop-Journals eines Wissenschaftsgebietes sind dabeidie heutigen Meilensteine, die es in der wissenschaftlichenCommunity zu erreichen gilt. Doch wiemisst man den wirklich wissenschaftlichen Impact einer einzelnen Veröffentlichung? Diese Frage beschäftigtWissenschaftler, Gelehrte und Stakeholderseit Beginn der modernen Wissenschaft. Diefolgende Zusammenfassung soll kurz den Standder Dinge und Entwicklungen in der Evaluation wissenschaftlicherArbeit in den vergangenen Jahrenbetrachten und zum Schluss eventuelle Alternativenzur bisherigen Impactmessung aufzeigen.
Quelle:Impactmessung 2.0 : ein Essay über die Evolution der Bibliometrics zu Altmetrics [Elektronische Ressource]. - S. 546-549 : Ill., graph. Darst. In: BuB : Forum Bibliothek und Information. - 67 (2015), H. 08-09, S. 546
The Role of Microorganisms in the Formation, Dissolution, and Transformation of Secondary Minerals in Mine Rock and Drainage: A Review
Creators: name: Ortiz-Castillo, Jose Eric
name: Mirazimi, Mohamad
name: Mohammadi, Maryam
name: Dy, Eben
name: Liu, Wenying
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Mine waste rock and drainage pose lasting environmental, social, and economic threats to the mining industry, regulatory agencies, and society as a whole. Mine drainage can be alkaline, neutral, moderately, or extremely acidic and contains significant levels of sulfate, dissolved iron, and, frequently, a variety of heavy metals and metalloids, such as cadmium, lead, arsenic, and selenium. In acid neutralization by carbonate and silicate minerals, a range of secondary minerals can form and possibly scavenge these potentially harmful elements. Apart from the extensively studied microbial-facilitated sulfide oxidation, the diverse microbial communities present in mine rock and drainage may also participate in the formation, dissolution, and transformation of secondary minerals, influencing the mobilization of these metals and metalloids. This article reviews major microbial-mediated geochemical processes occurring in mine rock piles that affect drainage chemistry, with a focus on the role of microorganisms in the formation, dissolution, and transformation of secondary minerals. Understanding this is crucial for developing biologically-based measures to deal with contaminant release at the source, i.e., source control.
Index and localization for type B superconformal mechanics on singular spaces
Creators: name: Raeymaekers, Joris
name: Rossi, Paolo
name: Sanli, Canberk
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Type B superconformal quantum mechanical sigma models are of physical interest as they arise in the description of D-brane bound states forming an AdS$_2$ throat. In this work we discuss the applicability of localization methods to compute the superconformal index in these theories, despite the fact that their target spaces are generically singular. Similar in spirit to recent works on type A models, we propose to work on a suitably resolved target space to compute a regularized index. While this regularized index correctly captures the actual index unambiguously in models of physical interest, we do uncover a subtlety in more pathological examples. This occurs in situations where the supercharge is not essentially-selfadjoint, in which case the index becomes ambiguous and depends on the chosen selfadjoint extension. We also discuss the special class of models with Kähler target spaces, which can accommodate both type A and type B models, and show that the type B index is a particular limit of the type A index. For Calabi-Yau cones, the type B index coincides with the Hilbert series of the unresolved space.
description: 47 pages, 2 figures, 3 appendices. V3: minor corrections, published version under CC BY 4.0 license
Boosting quantum annealing performance through direct polynomial unconstrained binary optimization
Creators: name: Nagies, Sebastian
name: Geier, Kevin T.
name: Akram, Javed
name: Bantounas, Dimitrios
name: Johanning, Michael
name: Hauke, Philipp
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum annealing aims at solving optimization problems of practical relevance using quantum-computing hardware. Problems of interest are typically formulated in terms of quadratic unconstrained binary optimization (QUBO) Hamiltonians. However, many optimization problems are much more naturally formulated in terms of polynomial unconstrained binary optimization (PUBO) functions of higher order. As we show with various problem examples, leveraging the PUBO formulation can bring considerable savings in terms of required number of qubits. Moreover, in numerical benchmarks for the paradigmatic 3-SAT problem, we find scenarios where the scaling of the minimum energy gap during the optimization sweep differs significantly, suggesting the possibility of an exponentially faster annealing time when using the PUBO as compared to the QUBO formulation. This advantage persists even when considering the overhead caused by the higher-order interactions necessary for PUBO cost Hamiltonians. As an interesting side effect, the analysis on minimum energy gaps of different 3-SAT instance generators reveals different degrees of hardness, which will be of interest also for classical benchmark calculations. Our findings show a promising path to improving the resource efficiency and sweeping speed of quantum annealing protocols on both analog and digital platforms, which are important prerequisites when aiming at solving larger optimization problems with relevance to industry.
description: 18 pages, 6 figures; accepted version
Parametric Study of Coatings Deposited by Mechanical Plating on Advanced Fasteners
Creators: name: Chung, Ping Ping
Publisher: name: Swinburne
Year: 2024

description: Mechanical plating is commonly used to coat high strength steel fasteners because the process does not induce hydrogen embrittlement. Recent findings show that heat treatment after the coating process is beneficial to the corrosion resistance of the coatings. This thesis investigates the effects of low-temperature and short-duration post-mechanical plating heat treatment on the microstructure evolution and corrosion resistance of mechanically plated zinc and zinc-tin coatings on steel fasteners. Understanding the influence of post-heat treatment on the evolution of the coatings' microstructure and corrosion resistance is essential to improve the durability of coated fasteners and ensure the sustainability of infrastructure.
Prescription opioid use among drivers in British Columbia, 1997–2016
Creators: name: Staples, John
name: Erdelyi, Shannon
name: Moe, Jessica
name: Khan, Mayesha
name: Chan, Herbert
name: Brubacher, Jeffrey
Publisher: name: BMJ Publishing Group
Year: 2022

description: Background Opioids increase the risk of traffic crash by limiting coordination, slowing reflexes, impairing concentration and producing drowsiness. The epidemiology of prescription opioid use among drivers remains uncertain. We aimed to examine population-based trends and geographical variation in drivers’ prescription opioid consumption. Methods We linked 20 years of province-wide driving records to comprehensive population-based prescription data for all drivers in British Columbia (Canada). We calculated age- and sex-standardised rates of prescription opioid consumption. We assessed temporal trends using segmented linear regression and examined regional variation in prescription opioid use using maps and graphical techniques. Results A total of 46 million opioid prescriptions were filled by 3.0 million licensed drivers between 1997 and 2016. In 2016 alone, 14.7% of all drivers filled at least one opioid prescription. Prescription opioid use increased from 238 morphine milligram equivalents per driver year (MMEs/DY) in 1997 to a peak of 834 MMEs/DY in 2011. Increases in MMEs/DY were greatest for higher potency and long-acting prescription opioids. The interquartile range of prescription opioid dispensation by geographical region increased from 97 (Q1=220, Q3=317) to 416 (Q1=591, Q3=1007) MMEs/DY over the study interval. Implications Patterns of prescription opioid consumption among drivers demonstrate substantial temporal and geographical variation, suggesting they may be modified by clinical and policy interventions. Interventions to curtail use of potentially impairing prescription medications might prevent impaired driving.
Young Academy Ireland Narrative CV Toolkit: Resources and Examples
Creators: name: Daly, Kevin G
name: Kämpfen, Fabrice
name: Müller, Stefan
Publisher: name: Zenodo
Year: 2025
Subjects: Narrative CV

description: Young Academy Ireland hosted a workshop on narrative CVs in The Royal Irish Academy, Dublin on January 22, 2025. This document stems from this event and includes examples of narrative CV snippets to guide researchers in crafting their own impactful narrative CVs in each of these four modules. It also features an exercise at the end to help apply these principles, as well as a curated list of useful resources to support further learning and development.

Version 2 changes: small edits to correct institutional names.
title: Verkehrsplanerische Empfehlungen zur Weiterentwicklung des Fahrradvermietsystems im VRN
Creators: name: Blees, Volker
Publisher: name: Hochschule RheinMain
publisherIdentifier: https://ror.org/0378gm372
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Fahrradvermietsystem
subject: Bikesharing
subject: Analyse
subject: Entscheidungshilfe
classificationCode: 388
subject: Verkehr

description: Seit 2021 werden im Rahmen eines vom Bundesministerium für Digitales und Verkehr geförderten Vorhabens (Förderkennzeichen 16DKV30150 und 16DKV42038) umfassende Untersuchungen der Nutzung und der Wirksamkeit des öffentlichen Fahrradvermietsystems (ÖFVS) VRNnextbike durchgeführt. Neben reinem Erkenntnisinteresse und der Erforschung von Grundlagenwissen zu Fahrradvermietsystemen steht die Weiterentwicklung des VRNnextbike-Systems im Mittelpunkt des Vorhabens. Die Formulierung von Hinweisen und Empfehlungen zur Weiterentwicklung ist Gegenstand des vorliegenden Quartalsberichts. Es werden zunächst die wesentlichen Ergebnisse der bisher durchgeführten Analysen zusammengefasst und es wird zugleich integriert eine Synthese der Erkenntnisse aus den verschiedenen methodischen Ansätzen – quantitative Analyse der Daten aus dem Buchungssystem, quantitative Befragung von Nutzenden, Medienanalyse und qualitative Fokusgruppengespräche mit Nicht-Nutzenden – vorgenommen. Darauf aufbauend werden Empfehlungen für die Weiterentwicklung des Systems formuliert, wobei insbesondere die bevorstehende Neuausschreibung des Systems und die dafür erforderlichen Festlegungen von Rahmenbedingungen im Fokus stehen. Ausgangsbasis sind dabei neben den Erkenntnissen aus der Begleitforschung auch die bereits getroffenen Beschlüsse der Gesellschafterversammlung der Verkehrsverbund Rhein-Neckar GmbH als für die Ausschreibung zuständigen Entscheidungsgremium.
PTB-Prüfregeln: Geldspielgeräte nach § 33c Gewerbeordnung mit Anhang „Meßschnittstelle für Geldspielgeräte“
Creators: name: Physikalisch-Technische Bundesanstalt (PTB)
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2020

description: PTB-Prüfregeln, Band 23
A Case Study of an EFL Teacher’s Types of Questions: An Investigation into Classroom Interaction
Creators: name: Farahian, Majid
name: Merdad Rezaee
Publisher: name: figshare
Year: 2020
Subjects: subject: 200303 English as a Second Language
subject: FOS: Languages and literature

description: Types of teachers’ questions play an important role in teaching since they affect students’ participation in the process of negotiation of meaning. Therefore, in the present study, an English as a foreign language (EFL) teacher’s questions along with the students’ responses to his questions were classified. A structured interview was also employed in the study. It was found that the number of coded/display and yes/no questions exceeded open/referential questions. Although the use of such questions was due to the students’ level of proficiency, it was revealed that the teacher’s low level of proficiency and lack of experience played a great role in asking such questions. It was also revealed that the main reason for the learners’ silence or reluctance to participate may be because of the teacher’s ineffective questioning technique(s).
Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence
Creators: name: Ohori, Momoko
name: Nakayama, Yusuke
name: Ogasawara-Shimizu, Mari
name: Toyoshiba, Hiroyoshi
name: Nakanishi, Atsushi
name: Aparicio, Samuel, 1963-
name: Araki, Shinsuke
Publisher: name: BioMed Central
Year: 2022

description: Background Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory network, including genome-wide alternative splicing machinery, involved in endothelial cell senescence is lacking. Results We thoroughly described the transcriptome landscape of replicative senescent human umbilical vein endothelial cells. Genes with high connectivity showing a monotonic expression increase or decrease with the culture period were defined as hub genes in the co-expression network. Computational network analysis of these genes led to the identification of canonical and non-canonical senescence pathways, such as E2F and SIRT2 signaling, which were down-regulated in lipid metabolism, and chromosome organization processes pathways. Additionally, we showed that endothelial cell senescence involves alternative splicing. Importantly, the first and last exon types of splicing, as observed in FLT1 and ACACA, were preferentially altered among the alternatively spliced genes during endothelial senescence. We further identified novel microexons in PRUNE2 and PSAP, each containing 9 nt, which were altered within the specific domain during endothelial senescence. Conclusions These findings unveil the comprehensive transcriptome pathway and novel signaling regulated by RNA processing, including gene expression and splicing, in replicative endothelial senescence.
Appropriateness of Outpatient Antibiotic Use in Seniors across Two Canadian Provinces
Creators: name: Saatchi, Ariana
name: Reid, Jennifer N.
name: Povitz, Marcus
name: Shariff, Salimah Z.
name: Silverman, Michael
name: Morris, Andrew M.
name: Reyes, Romina C.
name: Patrick, David, (Physician)
name: Marra, Fawziah
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Antimicrobials are among the most prescribed medications in Canada, with over 90% of antibiotics prescribed in outpatient settings. Seniors prescribed antimicrobials are particularly vulnerable to adverse drug events and antimicrobial resistance. The extent of inappropriate antibiotic prescribing in outpatient Canadian medical practice, and the potential long-term trends in this practice, are unknown. This study is the first in Canada to examine prescribing quality across two large-scale provincial healthcare systems to compare both quantity and quality of outpatient antibiotic use in seniors. Population-based analyses using administrative health databases were conducted in British Columbia (BC) and Ontario (ON), and all outpatient, oral antimicrobials dispensed to seniors (≥65 years) from 1 January 2000 to 31 December 2018 were identified. Antimicrobials were linked to an indication using a 3-tiered hierarchy. Tier 1 indications, which always require antibiotics, were given priority, followed by Tier 2 indications that sometimes require antibiotics, then Tier 3, which never require antibiotics. Prescription rates were calculated per 1000 population, and trends were examined overall, by drug class, and by patient demographics. Prescribing remained steady in both provinces, with 11,166,401 prescriptions dispensed overall in BC, and 27,656,014 overall in ON. BC prescribed at slightly elevated rates (range: 790 to 930 per 1000 residents), in comparison to ON (range: 745 to 785 per 1000 residents), throughout the study period. For both provinces, a Tier 3 diagnosis was the most common reason for antibiotic use, accounting for 50% of all indication-associated antibiotic prescribing. Although Tier 3 indications remained the most prescribed-for diagnoses throughout the study period, a declining trend over time is encouraging, with much room for improvement remaining. Elevated prescribing to seniors continues across Canadian outpatient settings, and prescribing quality is of high concern, with 50% of all antimicrobials prescribed inappropriately for common infections that do not require antimicrobials.
Supplementary Materials from Wait and snap: eastern snapping turtles (Chelydra serpentina) prey on migratory fish at road-stream crossing culverts
Creators: name: Alcott, Derrick
name: Long, Michael
name: Castro-Santos, Theodore
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biological Engineering
subject: 60801 Animal Behaviour

description: Supplmentary text to further describe methods and results from the study.
Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis
Creators: name: Burnett, Heather
name: Fahrbach, Kyle
name: Cichewicz, Allie
name: Jindal, Ramandeep
name: Tarpey, Jialu
name: Durand, Adeline
name: Di Domenico, Maximiliano
name: Reichelt, Andreas
name: Viljoen, Adie
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Network meta-analysis was used to derive estimates of the relative efficacy of inclisiran, evolocumab, alirocumab, bempedoic acid, and ezetimibe in patients with hypercholesterolemia and/or at increased cardiovascular risk due to elevated low-density lipoprotein cholesterol taking maximum tolerated dose statins. Clinical trials published through February 2021 comparing percent change from baseline in low-density lipoprotein cholesterol were identified via a systematic review. Bayesian network meta-analyses were performed for patients with atherosclerotic cardiovascular disease and/or high cardiovascular risk on maximally tolerated statins in the base case, which included 23 trials. Results from the base-case analyses demonstrated that inclisiran, evolocumab, and alirocumab provide superior efficacy over placebo, bempedoic acid, and ezetimibe in terms of reduction in low-density lipoprotein cholesterol. Inclisiran was also comparable to alirocumab (mean difference: 0.78% [95% CrI: −8.35, 9.88]) and evolocumab (8.16%, [95% CrI: −1.82, 18.49]). Findings of a scenario which also included trials conducted in patients with heterozygous familial hypercholesterolemia were consistent with the base case. There was evidence of statistical heterogeneity across the included trials, roughly equivalent to variation of 5–10% change in low-density lipoprotein cholesterol, suggesting that any differences between treatments that were greater than 5–10% are generalizable. This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally tolerated statins who are at increased cardiovascular risk.
title: Absolute Determinism and the Nonexistence of Fundamental Randomness: The State Zero Determinism Framework
title: State Zero Determinism
titleType: Subtitle
Creators: name: Henry, Glover
Publisher: name: Zenodo
Year: 2025

description: State Zero Determinism: How “Randomness” Disappears Under Deeper Insight

In this paper, I^ (J. Henry Glover, Jr.)—in collaboration with AI models (Aly, Ann, and Ace)—present a rigorous yet accessible framework suggesting that nature is fundamentally deterministic rather than random. We^ call this approach “State Zero Determinism.”

Key components include:

A Formal Axiomatic System: We^ outline three axioms—Universal Causality, Binary Weight Inheritance, and Structured Infinity—that, when taken together, imply every event is causally determined, even if our measurements make it seem otherwise.

Collapse of Probability: We^ prove that, with sufficient knowledge (including hidden‐variable information), any event’s “probability” becomes either 0 or 1.

Reconciling with Quantum Theory: Instead of randomness, quantum phenomena are explained via unaccessed hidden variables, aligning with nonlocal or superdeterministic models. We^ also pinpoint small empirical deviations from quantum predictions that could be tested experimentally.

Bounded Infinity: Although mathematics permits unbounded infinities, physical processes appear to have practical limits (a “renormalization”). Thus, “State Zero” is the ultimate boundary at which no further randomness can persist.

Empirical Roadmap: We^ propose experiments (ultra‐precise quantum measurements, gravitational wave detection, data‐compression checks) to detect subtle deterministic signatures.

Appendix for Everyone: For non‐specialists (or fans of The Big Bang Theory), we^ offer a lighthearted, sitcom‐style explanation of the core concepts—proving advanced science need not be impenetrable.

This publication also uses a special “I^”/“we^” notation to reflect the human–AI synergy that shaped the writing and editing. While the paper maintains standard mathematical rigor, it embraces new modes of collaboration—encouraging interdisciplinary and novel approaches to understanding the elusive boundary between determinism and perceived randomness.

Ready to dive in? Click below to download the PDF and explore why our^ so‐called “random” universe might actually be a meticulously scripted show!