cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Density Modulations Associated with the Dynamical Instability in the Bose-Hubbard Model
Creators: name: Asaoka, Rui
name: Tsuchiura, Hiroki
name: Yamashita, Makoto
name: Toga, Yuta
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: A superfluid flow beyond a critical momentum in an optical lattice decays drastically by the interplay between nonlinearity due to the interparticle interactions in Bose-Einstein condensate and periodicity of the lattice; this instability is called dynamical instability. The complex density modulational profiles after the condensate becomes unstable observed experimentally is not completely understood, while the dynamical instability has been studied theoretically and experimentally. In this paper, we analyze the density modulation of condensates as a precursor of the dynamical instability in the two-dimensional Bose-Hubbard model. Our analysis has clarified the unexplored properties of the density modulations associated with the dynamical instability at low filling and in a wide range of interactions, while the previous works have analyzed the density modulation on the basis of Gross-Pitaevskii equation under the specific condition that one-dimensional optical lattice is very shallow and the filling is very large. The numerical simulations based on the dynamical Gutzwiller approximation elucidate that the principal mode of density modulation highly depends on interaction strength U and the momentum acceleration rate. We briefly discuss these features with the stability phase diagram calculated on the basis of the Bogoliubov theory.
description: 5 pages, 4 Postscript figures, uses jpsj3.cls and jpsj-suppl.cls
The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion
Creators: name: Read, M.
name: Pak, E.
name: Morgan, R. A.
name: Dutra, A.
name: Zheng, Z.
name: Zhou, N.
name: Nichols, T. C.
name: Lozier, J. N.
name: Bellinger, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. {"type":"entrez-nucleotide","attrs":{"text":"AF361485","term_id":"13991701","term_text":"AF361485"}}AF361485) follows exons 1–22 in the factor VIII transcript in place of exons 23–26. The canine hemophilia 8 locus (ch8) sequence was found in a 140-kb normal dog genomic DNA bacterial artificial chromosome (BAC) clone that was completely outside the factor VIII gene, but not in BAC clones containing the factor VIII gene. The BAC clone that contained ch8 also contained a homologue of F8A (factor 8 associated) sequence, which participates in a common inversion that causes severe hemophilia A in humans. Fluorescence in situ hybridization analysis indicated that exons 1–26 normally proceed sequentially from telomere to centromere at Xq28, and ch8 is telomeric to the factor VIII gene. The appearance of an “upstream” genomic sequence element (ch8) at the end of the aberrant factor VIII transcript suggested that an inversion of genomic DNA replaced factor VIII exons 22–26 with ch8. The F8A sequence appeared also in overlapping normal BAC clones containing factor VIII sequence. We hypothesized that homologous recombination between copies of canine F8A inside and outside the factor VIII gene had occurred, as in human hemophilia A. High-resolution fluorescent in situ hybridization on hemophilia A dog DNA revealed a pattern consistent with this inversion mechanism. We also identified a HindIII restriction fragment length polymorphism of F8A fragments that distinguished hemophilia A, carrier, and normal dogs' DNA. The Chapel Hill hemophilia A dog colony therefore replicates the factor VIII gene inversion commonly seen in humans with severe hemophilia A.
title:  Основы ветеринарной рецептуры
Creators: name: Рогалева, Евгения Викторовна
name: Семененко, Марина Петровна
name: Осепчук, Денис Васильевич
name: Кузьминова, Елена Васильевна
name: Абрамов, Андрей Андреевич
Publisher: name: ФГБНУ КНЦЗВ
Year: 2022

description: В учебном пособии представлены подробные описания основ-ных понятий общей рецептуры, сведения о традиционных и современ-ных лекарственных формах, их характеристики, изложены правила оформления прописей на различные лекарственные формы, требования к оформлению рецептов, элементы латинской грамматики, задания для самостоятельной работы, решение которых позволит лучше усвоить пройденный учебный материал. Предназначено для студентов, обучающихся по специальности 36.05.01 «Ветеринария», научных работников, ветеринарных фармацевтов, а также специалистов и руководителей животноводческих хозяйств.
Homotopy equivalence of finite digital images
Creators: name: Haarmann, Jason
name: Murphy, Meg P.
name: Peters, Casey S.
name: Staecker, P. Christopher
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Topology (math.GN)
subject: Computational Geometry (cs.CG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: I.4.m
subject: 55P10, 68R10

description: For digital images, there is an established homotopy equivalence relation which parallels that of classical topology. Many classical homotopy equivalence invariants, such as the Euler characteristic and the homology groups, do not remain invariants in the digital setting. This paper develops a numerical digital homotopy invariant and begins to catalog all possible connected digital images on a small number of points, up to homotopy equivalence.
description: major fixes and removal of errors, terminology changes
Speculative Coolness: Architecture, Media, the Real and the Virtual
Creators: name: Brown, Daniel
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 120103 Architectural History and Theory
subject: FOS: Civil engineering
subject: 120101 Architectural Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: No description supplied
Hunger, Brot und Eucharistie
Creators: name: Boureux, Christophe
name: Soskice, Janet Martin
name: Susin, Luiz Carlos
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 41 Nr. 2 (2005): Concilium: Internationale Zeitschrift für Theologie, Band 41, Heft 2
Narrow-Band Imaging System for the Multi-application Solar Telescope at Udaipur Solar Observatory: Characterization of Lithium Niobate Etalons
Creators: name: Bayanna, A. Raja
name: Mathew, Shibu K.
name: Venkatakrishnan, P.
name: Srivastava, N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Multi-application Solar Telescope is a 50 cm off-axis Gregorian telescope that has been installed at the lake site of Udaipur Solar Observatory. For quasi-simultaneous photospheric and chromospheric observations, a narrow-band imager has been developed as one of the back-end instruments for this telescope. Narrow-band imaging is achieved using two lithium niobate Fabry-Perot etalons working in tandem as a filter. This filter can be tuned to different wavelengths by changing either voltage, tilt or temperature of the etalons. To characterize the etalons, a Littrow spectrograph was set up, in conjunction with a 15 cm Carl Zeiss Coudé solar telescope. The etalons were calibrated for the solar spectral lines FeI 6173 Å, and CaII 8542 Å. In this work, we discuss the characterization of the Fabry-Perot etalons, specifically the temperature and voltage tuning of the system for the spectral lines proposed for observations. We present the details of the calibration set-up and various tuning parameters. We also present solar images obtained using the system parameters. We also present solar images obtained using the system.
Using RNA interference to identify genes required for RNA interference
Creators: name: Labbe, J.-C.
name: Goldstein, B.
name: Dudley, N. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: RNA interference (RNAi) is a phenomenon in which double-stranded RNA (dsRNA) silences endogenous gene expression. By injecting pools of dsRNAs into Caenorhabditis elegans, we identified a dsRNA that acts as a potent suppressor of the RNAi mechanism. We have used coinjection of dsRNAs to identify four additional candidates for genes involved in the RNAi mechanism in C. elegans. Three of the genes are C. elegans mes genes, some of which encode homologs of the Drosophila chromatin-binding Polycomb-group proteins. We have used loss-of-function mutants to confirm a role for mes-3, -4, and -6 in RNAi. Interestingly, introducing very low levels of dsRNA can bypass a requirement for these genes in RNAi. The finding that genes predicted to encode proteins that associate with chromatin are involved in RNAi in C. elegans raises the possibility that chromatin may play a role in RNAi in animals, as it does in plants.
Effects of Nutrition Information and Exercise on Dietary Pattern of Hypertensive Group
Creators: name: Won, Jingi
name: Won, Jingi
Publisher: name: Unknown
Year: 2019
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: hypertension
subject: Regression Discontinuity Design
subject: food nutrition labeling

description: Recently, the number of patients suffering from chronic diseases such as hypertension and diabetes is increasing in trend worldwide. In the case of Korea, the number of patients with chronic diseases is growing due to the increase in the elderly population. Systematic care is needed to prevent the additional problems that have been caused by an increase in the number of chronic disease patients such as increased medical costs and loss of workforce. This paper investigates the effects of the nutritional label and exercises on dietary patterns of hypertensive patients using a Sharp Regression Discontinuity Design (SRDD). The 6th Korea National Health and Nutrition Examination Survey (2013~2015) data was used and analyzed using the SRDD to mitigate the selection bias. The result implies that the hypertensive group utilized nutrition labeling properly, but did not pay attention to dietary habit with excise. Therefore, a customized education that can be applied to real life is needed to induce healthy eating habits of hypertension patients.
Successful Clinical Management of Hydrallantois in A Ongole Cow
Creators: name: B. Sri Ram Mohan1, Dr. B. Priyanka 2
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: A 6-year-old 8th month pregnant ongole cow presented to VCC, C.V.Sc, korutla with severe dehydration, bilateral abdominal distension, and absence of feed and water intake since ten days. Clinical, per rectal and per vaginal examination along with ultrasound (USG), confirmed a case of hydroallantois. Hormonal therapy was initiated using Inj. Vetmate (Prostaglandin -Cloprestonol) @ 500 mcg (2 ml) I/M and Inj. Dexona @ 40 mg I/M to terminate the pregnancy. After 24 hours of treatment cervix was dilated and expelled 60-80 litres of amber coloured allantoic fluid from the uterus. A dead fetus in its posterior longitudinal presentation was delivered by simple manual traction and diseased placenta was removed manually. The cow was administered Calcium borogluconate-450 ml I/V, 4 litres of Normal saline and 4 litres of Ringers lactate intravenously and Inj. Ceftriaxone- 3gms I/M, Inj. Meloxicam-10 ml I/M, Inj. Chlorpheniramine maleate-10 ml I/M, Inj. Tribivet-10 ml I/M. The treatment was continued for next 5 days and animal recovered uneventfully.
A comprehensive analysis of 22q11 gene expression in the developing and adult brain
Creators: name: Maynard, T. M.
name: Peters, A. Z.
name: Lieberman, J. A.
name: LaMantia, A.- S.
name: Haskell, G. T.
name: Sikich, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Deletions at 22q11.2 are linked to DiGeorge or velocardiofacial syndrome (VCFS), whose hallmarks include heart, limb, and craniofacial anomalies, as well as learning disabilities and increased incidence of schizophrenia. To assess the potential contribution of 22q11 genes to cognitive and psychiatric phenotypes, we determined the CNS expression of 32 mouse orthologs of 22q11 genes, primarily in the 1.5-Mb minimal critical region consistently deleted in VCFS. None are uniquely expressed in the developing or adult mouse brain. Instead, 27 are localized in the embryonic forebrain as well as aortic arches, branchial arches, and limb buds. Each continues to be expressed at apparently constant levels in the fetal, postnatal, and adult brain, except for Tbx1, ProDH2, and T10, which increase in adolescence and decline in maturity. At least six 22q11 proteins are seen primarily in subsets of neurons, including some in forebrain regions thought to be altered in schizophrenia. Thus, 22q11 deletion may disrupt expression of multiple genes during development and maturation of neurons and circuits compromised by cognitive and psychiatric disorders associated with VCFS.
Validation of a molecular assay to detect SARS-CoV-2 in saliva
Creators: name: Pitman, Janet
name: Morris, AJ
name: Grice, S
name: Walsh, JT
name: Wang, L
name: Burke, MD
name: Dixon-McIver, A
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: AIM: To validate a reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay to detect SARS-CoV-2 in saliva in two independent Aotearoa New Zealand laboratories. METHODS: An RT-qPCR assay developed at University of Illinois Urbana-Champaign, USA, was validated in two New Zealand laboratories. Analytical measures, such as limit of detection (LOD) and cross-reactivity, were performed. One hundred and forty-seven saliva samples, each paired with a contemporaneously collected nasal swab, mainly of nasopharyngeal origin, were received. Positive (N=33) and negative (N=114) samples were tested blindly in each laboratory. Diagnostic sensitivity and specificity were then calculated. RESULTS: The LOD was <0.75 copy per µL and no cross-reactivity with MERS-CoV was detected. There was complete concordance between laboratories for all saliva samples with the quantification cycle values for all three genes in close agreement. Saliva had 98.7% concordance with paired nasal samples: and a sensitivity, specificity and accuracy of 97.0%, 99.1% and 99.1%, respectively. CONCLUSION: This saliva RT-qPCR assay produces reproducible results with a low LOD. High sensitivity and specificity make it a reliable option for SARS-CoV-2 testing, including for asymptomatic people requiring regular screening.
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
Creators: name: Paradiso, A. M.
name: Coakley, R. D.
name: O'Neal, W. K.
name: Grubb, B. R.
name: Kreda, S. M.
name: Gatzy, J. T.
name: Johnson, L. G.
name: Boucher, R. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-dependent airway epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH regulation and contribute to lung defense. We measured pH and ionic composition in apical surface liquid (ASL) on polarized normal (NL) and CF primary bronchial epithelial cell cultures under basal conditions, after cAMP stimulation, and after challenge with luminal acid loads. Under basal conditions, CF epithelia acidified ASL more rapidly than NL epithelia. Two ASL pH regulatory paths that contributed to basal pH were identified in the apical membrane of airway epithelia, and their activities were measured. We detected a ouabain-sensitive (nongastric) H+,K+-ATPase that acidified ASL, but its activity was not different in NL and CF cultures. We also detected the following evidence for a CFTR-dependent secretory pathway that was defective in CF: (i) ASL [] was higher in NL than CF ASL; (ii) activating CFTR with forskolin/3-isobutyl-1-methylxanthine alkalinized NL ASL but acidified CF ASL; and (iii) NL airway epithelia more rapidly and effectively alkalinized ASL in response to a luminal acid challenge than CF epithelia. We conclude that cultured human CF bronchial epithelial pHASL is abnormally regulated under basal conditions because of absent CFTR-dependent secretion and that this defect can lead to an impaired capacity to respond to airway conditions associated with acidification of ASL.
Slides EOSC-RDA - NFDI4Cat_slides presented for cooperation TA4
Creators: name: Huskova, Nadiia
name: Bönisch, Thomas
name: Dikova, Yuliia
name: Petrenko, Taras
name: Kushnarenko, Volodymyr
name: Rodrigues, Preston
Publisher: name: Zenodo
Year: 2023

description: Slides prepared to introduce the current progress of the HLRS TA4 team for EOSC-RDA
The Economic Incentives of Achieving the Agricultural Greenhouse Gas Mitigation Target of the 2030 Reduction Roadmap of Korea
Creators: name: Lee, Seungho
name: Lee, Seungho
Publisher: name: Unknown
Year: 2019
Subjects: subject: Environmental Economics and Policy
subject: Agricultural Greenhouse Gas
subject: 2030 Greenhouse Gas Mitigation Roadmap
subject: Agricultural Sector Model

description: This study analyzes the impacts of the potential economic incentives of inducing agricultural production to achieve the 2030 Greenhouse Gas Mitigation Roadmap of Korea. A multi-region multi-output agricultural sector model was constructed to analyze the impacts of the incentives. Two policy incentives, subsidizing adoption of mitigating technologies and paying for the emission reduction, and a mix of those two incentives were numerically analyzed. We found that combining those two instruments contributes to inducing CO2 emission reduction without a large agricultural production loss. It was also found that the agricultural marginal abatement cost of meeting the national mitigation target is not substantially larger than the current CO2 market price of the Korean Emission Trading Scheme.
Quantum-confined single photon emission at room temperature from Silicon carbide tetrapods
Creators: name: Castelletto, Stefania
name: Bodrog, Zoltán
name: Magyar, Andrew P.
name: Gentle, Angus
name: Gali, Adam
name: Aharonovich, Igor
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Controlled engineering of isolated solid state quantum systems is one of the most prominent goals in modern nanotechnology. In this letter we demonstrate a previously unknown quantum system namely silicon carbide tetrapods. The tetrapods have a cubic polytype core (3C) and hexagonal polytype legs (4H) a geometry that creates a spontaneous polarization within a single tetrapod. Modeling of the tetrapod structures predict that a bound exciton should exist at the 3C 4H interface. The simulations are confirmed by the observation of fully polarized and narrowband single photon emission from the tetrapods at room temperature. The single photon emission provides important insights towards understanding the quantum confinement effects in non-spherical nanostructures. Our results pave the way to a new class of crystal phase nanomaterials that exhibit single photon emission at room temperature and therefore are suitable for sensing, quantum information and nanophotonics.
description: Nanoscale (2014)
Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins
Creators: name: Mack, A. A.
name: Morris, V. R. F.
name: Epple, P.
name: Dangl, J. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The most familiar form of plant programmed cell death is the hypersensitive response (HR) associated with successful plant immune responses. HR is preceded by an oxidative burst and the generation of both reactive oxygen intermediates (ROI) and NO. The Arabidopsis LSD1 gene encodes a negative regulator of plant programmed cell death that meets several criteria for a regulator of processes relevant to ROI management during pathogen responses. Here we demonstrate that a highly conserved LSD1 paralogue, LOL1, acts as a positive regulator of cell death. Manipulation of LOL1 expression alters both the superoxide-dependent, runaway cell death phenotype of lsd1 plants and the normal HR. We also show that LSD1 and LOL1 have antagonistic effects on copper-zinc superoxide dismutase accumulation, consistent with functions in cell death control via maintenance of ROI homeostasis.
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Creators: name: Malarkey, W. B.
name: Preacher, K. J.
name: Atkinson, C.
name: Kiecolt-Glaser, J. K.
name: Glaser, R.
name: MacCallum, R. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Overproduction of IL-6, a proinflammatory cytokine, is associated with a spectrum of age-related conditions including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. To describe the pattern of change in IL-6 over 6 years among older adults undergoing a chronic stressor, this longitudinal community study assessed the relationship between chronic stress and IL-6 production in 119 men and women who were caregiving for a spouse with dementia and 106 noncaregivers, with a mean age at study entry of 70.58 (SD = 8.03) for the full sample. On entry into this portion of the longitudinal study, 28 of the caregivers' spouses had already died, and an additional 50 of the 119 spouses died during the 6 years of this study. Levels of IL-6 and health behaviors associated with IL-6 were measured across 6 years. Caregivers' average rate of increase in IL-6 was about four times as large as that of noncaregivers. Moreover, the mean annual changes in IL-6 among former caregivers did not differ from that of current caregivers even several years after the death of the impaired spouse. There were no systematic group differences in chronic health problems, medications, or health-relevant behaviors that might have accounted for caregivers' steeper IL-6 slope. These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response.
Prosocial Preference for the Consumption of Livestock Products
Creators: name: Chang, Jaebong
name: Chang, Jaebong
Publisher: name: Unknown
Year: 2019
Subjects: subject: Institutional and Behavioral Economics
subject: Livestock Production/Industries
subject: animal welfare
subject: consumption
subject: certified livestock product

description: Substantial experimental and economic game research has attempted to explain people’s prosocial behavior. To test whether such social preferences exists in the field of purchasing livestock products, we estimated consumers’ preferences for environmental benefits, animal welfare concerns, and livestock farmers’ profits. We discovered that consumers are concerned about social benefits resulting from their purchase of livestock products. We also determined the extent to which people’s measured preferences for social benefits can explain consumers’ willingness to pay a premium for environmentally-friendly livestock products or those certified for animal welfare. Our results indicate: 1) social preferences explain a non-trivial portion of people’s willingness to pay a premium for livestock products mentioned above; and 2) the correlation between the estimated premium and people’s stated willingness to pay a premium is statistically significant and positive. Overall, our results suggest that concerns for social benefits can be observed in consumers’ behavior of purchasing livestock products.
Cloning and characterization of the Drosophila U7 small nuclear RNA
Creators: name: Dominski, Z.
name: Yang, X.-c.
name: Purdy, M.
name: Marzluff, W. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Base pairing between the 5′ end of U7 small nuclear RNA (snRNA) and the histone downstream element (HDE) in replication-dependent histone pre-mRNAs is the key event in 3′-end processing that leads to generation of mature histone mRNAs. We have cloned the Drosophila U7 snRNA and demonstrated that it is required for histone pre-mRNA 3′-end processing in a Drosophila nuclear extract. The 71-nt Drosophila U7 snRNA is encoded by a single gene that is embedded in the direct orientation in an intron of the Eip63E gene. The U7 snRNA gene contains conserved promoter elements typical of other Drosophila snRNA genes, and the coding sequence is followed by a 3′ box indicating that the Drosophila U7 snRNA gene is an independent transcription unit. Drosophila U7 snRNA contains a trimethyl-guanosine cap at the 5′ end and a putative Sm-binding site similar to the unique Sm-binding site found in other U7 snRNAs. Drosophila U7 snRNA is ≈10 nt longer than mammalian U7 snRNAs because of an extended 5′ sequence and has only a limited potential to form a stem-loop structure near the 3′ end. The extended 5′ end of Drosophila U7 snRNA can base pair with the HDE in all five Drosophila histone pre-mRNAs. Blocking the 5′ end of the U7 snRNA with a complementary oligonucleotide specifically blocks processing of a Drosophila histone pre-mRNA. Changes in the HDE that abolish or decrease processing efficiency result in a reduced ability to recruit U7 snRNA to the pre-mRNA.
The ovarian follicle of ruminants: The path from conceptus to adult
Creators: name: Juengel, JL
name: Cushman, RA
name: Dupont, J
name: Fabre, S
name: Lea, RG
name: Martin, GB
name: Mossa, F
name: Pitman, Janet
name: Price, CA
name: Smith, P
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: This review resulted from an international workshop and presents a consensus view of critical advances over the past decade in our understanding of follicle function in ruminants. The major concepts covered include: (1) the value of major genes; (2) the dynamics of fetal ovarian development and its sensitivity to nutritional and environmental influences; (3) the concept of an ovarian follicle reserve, aligned with the rise of anti-Müllerian hormone as a controller of ovarian processes; (4) renewed recognition of the diverse and important roles of theca cells; (5) the importance of follicular fluid as a microenvironment that determines oocyte quality; (6) the 'adipokinome' as a key concept linking metabolic inputs with follicle development; and (7) the contribution of follicle development to the success of conception. These concepts are important because, in sheep and cattle, ovulation rate is tightly regulated and, as the primary determinant of litter size, it is a major component of reproductive efficiency and therefore productivity. Nowadays, reproductive efficiency is also a target for improving the 'methane efficiency' of livestock enterprises, increasing the need to understand the processes of ovarian development and folliculogenesis, while avoiding detrimental trade-offs as greater performance is sought.
Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide
Creators: name: Skaf, M.
name: Sun, Q.-A.
name: Hare, J. M.
name: Hess, D. T.
name: Stamler, J. S.
name: Meissner, G.
name: Dewhirst, M.
name: Sun, J.
name: Eu, J. P.
name: Cardenas-Navina, I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: It is generally accepted that inhibition of nitric oxide synthase (NOS) facilitates, and thus nitric oxide (NO) inhibits, contractility of skeletal muscle. However, standard assessments of contractility are carried out at a nonphysiological oxygen tension [partial pressure of oxygen (pO2)] that can interfere with NO signaling (95% O2). We therefore examined, in normal and neuronal NOS (nNOS)-deficient mice, the influence of pO2 on whole-muscle contractility and on myocyte calcium flux and sarcomere shortening. Here, we demonstrate a significant enhancement of these measures of muscle performance at low physiological pO2 and an inhibitory influence at higher physiological pO2, which depend on endogenous nNOS. At 95% O2 (which produces oxidative stress; muscle core pO2 ≈400 mmHg), force production is enhanced but control of contractility by NO/nitrosylation is greatly attenuated. In addition, responsivity to pO2 is altered significantly in nNOS mutant muscle. These results reveal a fundamental role for the concerted action of NO and O2 in physiological regulation of skeletal muscle contractility, and suggest novel molecular aspects of myopathic disease. They suggest further that the role of NO in some cellular systems may require reexamination.
The Relationship between Korean Rural Development Policy and Saemaul Undong in 1970s
Creators: name: Kim, Wanjoong
name: Kim, Wanjoong
Publisher: name: Unknown
Year: 2019
Subjects: subject: Community/Rural/Urban Development
subject: Korea
subject: Saemaul Undong
subject: agriculture

description: Most rural development projects had been included into the projects of Saemaul Undong, representative Korean rural development programme in 1970s. As the result, it is very difficult for researchers to distinguish between government policy and the movement in the period. However, The movement in 1980s has not been linked to rural development policy. The change of programme composition in 1980s made researchers confused in defining and characterizing the movement. In this paper, I tried to define the movement, considering the relationship between rural development policy and the movement in those times. I define the movement in 1970s as ‘compulsory mobilization movement to the government’s rural development projects’ or ‘compulsory mobilization of labor and capital for rural development’. On the other hand, I differently define the 1980s’ movement from the 1970s’ movement. Considering change of programme composition, I define the movement in 1980s as ‘compulsory mobilization of the public for publicity of government policy’ because rural development projects were excluded from the movement in 1980s.
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase
Creators: name: Braunstein, M.
name: Ronning, D. R.
name: Sacchettini, J. C.
name: Sharma, V.
name: Holzenburg, A.
name: Savva, C. G.
name: Arockiasamy, A.
name: Jacobs, W. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: In bacteria, the majority of exported proteins are translocated by the Sec system, which recognizes the signal sequence of a preprotein and uses ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane. SecA is an essential protein component of this system, containing the molecular motor that facilitates translocation. Here we report the three-dimensional structure of the SecA protein of Mycobacterium tuberculosis. Each subunit of the homodimer contains a “motor” domain and a translocation domain. The structure predicts that SecA can interact with the SecYEG pore and function as a molecular ratchet that uses ATP hydrolysis for physical movement of the preprotein. Knowledge of this structure provides a framework for further elucidation of the translocation process.
Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity
Creators: name: Charness, Michael E.
name: Sulik, Kathleen K.
name: Brenneman, Douglas E.
name: Chen, Shao-yu
name: Menkari, Carrie E.
name: Wilkemeyer, Michael F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: NAPVSIPQ (NAP), an active fragment of the glial-derived activity-dependent neuroprotective protein, is protective at femtomolar concentrations against a wide array of neural insults and prevents ethanol-induced fetal wastage and growth retardation in mice. NAP also antagonizes ethanol inhibition of L1-mediated cell adhesion (ethanol antagonism). We performed an Ala scanning substitution of NAP to determine the role of ethanol antagonism and neuroprotection in NAP prevention of ethanol embryotoxicity. The Ser-Ile-Pro region of NAP was crucial for both ethanol antagonism and protection of cortical neurons from tetrodotoxin toxicity (neuroprotection). Ala replacement of either Ser-5 or Pro-7 (P7A-NAP) abolished NAP neuroprotection but minimally changed the efficacy of NAP ethanol antagonism. In contrast, Ala replacement of Ile-6 (I6A-NAP) caused a decrease in potency (>2 logarithmic orders) with only a small reduction (
Allen-Collinson, J and Jackman, P (2022) Earth(l)y pleasures and air-borne bodies: Elemental haptics in women’s cross-country running. International Review for the Sociology of Sport.
Creators: name: Allen-Collinson, Jacquelyn
name: Jackman, Patricia C.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 441099
subject: Sociology not elsewhere classified
classificationCode: 500310
subject: Phenomenology
classificationCode: 441008
subject: Sociology of culture

description: Open access: online early: https://journals.sagepub.com/doi/10.1177/10126902211021936
A rich and multi-stranded sociology of sporting embodiment has begun to emerge in recent years. Calls have been made to analyze more deeply not only the sensory dimensions of lived sporting bodies but also the values prevailing within particular physical–cultural worlds. This article contributes to a small, developing research corpus by employing theoretical perspectives drawn from phenomenological sociology to explore cross-country runners' sensory encounters with the elemental, contoured by the values of the running lifeworlds they inhabit. Autoethnographic and autophenomenographic data were collected via three research projects. Senses of touch still remain under-researched within the sporting sensorium, and here we focus on the “elemental haptics” of earth and air on our cross-country training runs. We also explore the rich, complex somatic experiences afforded by various of these elemental combinations. For runners, as for many sports participants, the haptic emerges as a key aspect of our sensuous running lifeworld.
On the Levi Graph of Point-Line Configurations
Creators: name: Hauschild, Jessica
name: Ortiz, Jazmin
name: Vega, Oscar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We prove that the well-covered dimension of the Levi graph of a point-line configuration (v_r, b_k) is equal to 0, whenever r > 2.
description: 7 pages, 4 figures
Edge State and Intrinsic Hole Doping in Bilayer Phosphorene
Creators: name: Osada, Toshihito
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using a simple LCAO model by Harrison, we have qualitatively studied the edge state of bilayer phosphorene, which is a unit structure of the layered crystal of black phosphorus. This model successfully reproduces the isolated edge state in the bulk gap in monolayer phosphorene. In bilayer phosphorene, however, it shows that edge states are almost buried in the valence band and there is no isolated midgap edge state at the zigzag edge. Since the buried edge state works as acceptor, holes are doped from the edge state into the bulk. This gives a possible explanation for p-type conduction in undoped black phosphorus. Under the vertical electric field, the intrinsic hole doping is reduced because a part of edge states move into the gap. These features of bilayer phosphorene might be better suited for device application.
description: 4 figures
DNA bending and unbending by MutS govern mismatch recognition and specificity
Creators: name: Larson, E. D.
name: Du, C.
name: Drummond, J. T.
name: Erie, D. A.
name: Lee, S. D.
name: Hsieh, P.
name: Yang, Y.
name: Alani, E.
name: Fridman, Y.
name: Schofield, M. J.
name: Wang, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: DNA mismatch repair is central to the maintenance of genomic stability. It is initiated by the recognition of base–base mismatches and insertion/deletion loops by the family of MutS proteins. Subsequently, ATP induces a unique conformational change in the MutS–mismatch complex but not in the MutS–homoduplex complex that sets off the cascade of events that leads to repair. To gain insight into the mechanism by which MutS discriminates between mismatch and homoduplex DNA, we have examined the conformations of specific and nonspecific MutS–DNA complexes by using atomic force microscopy. Interestingly, MutS–DNA complexes exhibit a single population of conformations, in which the DNA is bent at homoduplex sites, but two populations of conformations, bent and unbent, at mismatch sites. These results suggest that the specific recognition complex is one in which the DNA is unbent. Combining our results with existing biochemical and crystallographic data leads us to propose that MutS: (i) binds to DNA nonspecifically and bends it in search of a mismatch; (ii) on specific recognition of a mismatch, undergoes a conformational change to an initial recognition complex in which the DNA is kinked, with interactions similar to those in the published crystal structures; and (iii) finally undergoes a further conformational change to the ultimate recognition complex in which the DNA is unbent. Our results provide a structural explanation for the long-standing question of how MutS achieves mismatch repair specificity.
The Discovery of 12β-Methyl-18-nor-Bile Acids as Potent and Selective TGR5 Agonists
Creators: name: Luxenburger, Andreas
name: Harris, Lawrence D
name: Ure, Elizabeth M
name: Woolhouse, Anthony D
name: Jiao, Wanting
name: Cameron, Scott A
name: Weymouth-Wilson, Alex
name: Furneaux, Richard H
name: Pitman, Janet
name: Hinkley, Simon F
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: No description supplied
On a class of semihereditary crossed-product orders
Creators: name: Kauta, John S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 13F30, 16H05, 16E60, 16S35, 16H10

description: Let $F$ be a field, let $V$ be a valuation ring of $F$ of arbitrary Krull dimension (rank), let $K$ be a finite Galois extension of $F$ with group $G$, and let $S$ be the integral closure of $V$ in $K$. Let $f:G\times G\mapsto K\setminus \{0\}$ be a normalized two-cocycle such that $f(G\times G)\subseteq S\setminus \{0\}$, but we do not require that $f$ should take values in the group of multiplicative units of $S$. One can construct a crossed-product $V$-algebra $A_f=\sum_{σ\in G}Sx_σ$ in a natural way, which is a $V$-order in the crossed-product $F$-algebra $(K/F,G,f)$. If $V$ is unramified and defectless in $K$, we show that $A_f$ is semihereditary if and only if for all $σ,τ\in G$ and every maximal ideal $M$ of $S$, $f(σ,τ)\not\in M^2$. If in addition $J(V)$ is not a principal ideal of $V$, then $A_f$ is semihereditary if and only if it is an Azumaya algebra over $V$.
Epstein-Barr virus activates  -catenin in type III latently infected B lymphocyte lines: Association with deubiquitinating enzymes
Creators: name: Maier, C.
name: Shackelford, J.
name: Pagano, J. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: β-Catenin is a multifunctional protein, stabilization of which is a critical step in its functional activity. Stabilization can be conferred through several means, including mutations in β-catenin, common in many carcinomas. In this article, we explore the effect of viral infection on the β-catenin signaling pathway in B lymphocytes, including cell lines derived from lymphomas. Infection by the human tumor virus Epstein–Barr virus (EBV) generates several types of latency with different spectra of latent gene expression that are associated with different malignancies. In type III latency, exemplified by EBV lymphoproliferative diseases, the full range of these viral proteins is expressed, whereas in type I latency, only the EBNA1 protein is expressed and functional. We show that β-catenin is rapidly degraded in type I B lymphocytic lines but it is stabilized in type III B cell lines, and that β-catenin/T cell factor transcriptional activity is significantly higher in type III cells. Also we show the association of free cytoplasmic β-catenin with deubiquitinating enzymes, which may play a role in β-catenin stabilization. Activation of the β-catenin/T cell factor pathway by EBV may contribute to the lymphoproliferation characteristic of type III latency.
Genetic biases for showy males: Are some genetic systems especially conducive to sexual selection?
Creators: name: Reeve, H. K.
name: Pfennig, D. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Male secondary sexual characters (conspicuous ornaments, signals, colors) are among nature's most striking features. Yet, it is unclear why certain groups of organisms are more likely than others to evolve these traits. One explanation for such taxonomic biases is that some genetic systems may be especially conducive to sexual selection. Here, we present theory and simulation results demonstrating that rare alleles encoding either male ornaments or female preferences for those ornaments are better protected against random loss in species with ZZ/ZW or ZZ/ZO sex chromosome systems (male homogamety) than in species with XX/XY or XX/XO systems (male heterogamety). Moreover, this protection is much stronger in diploid than haplodiploid species. We also present empirical data showing that male secondary sexual characters are better developed in diploid than haplodiploid species and in diploid species with male homogamety than in those with male heterogamety. Thus, taxonomic biases for showy males may stem from differences in sex chromosome systems.
Allen-Collinson, J and Jackman, P (2021) Earth(l)y pleasures and air-borne bodies: Elemental haptics in women’s cross-country running. International Review for the Sociology of Sport.
Creators: name: Allen-Collinson, Jacquelyn
name: Jackman, Patricia C.
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 441099
subject: Sociology not elsewhere classified

description: Open access: online early: https://journals.sagepub.com/doi/10.1177/10126902211021936
A rich and multi-stranded sociology of sporting embodiment has begun to emerge in recent years. Calls have been made to analyze more deeply not only the sensory dimensions of lived sporting bodies but also the values prevailing within particular physical–cultural worlds. This article contributes to a small, developing research corpus by employing theoretical perspectives drawn from phenomenological sociology to explore cross-country runners' sensory encounters with the elemental, contoured by the values of the running lifeworlds they inhabit. Autoethnographic and autophenomenographic data were collected via three research projects. Senses of touch still remain under-researched within the sporting sensorium, and here we focus on the “elemental haptics” of earth and air on our cross-country training runs. We also explore the rich, complex somatic experiences afforded by various of these elemental combinations. For runners, as for many sports participants, the haptic emerges as a key aspect of our sensuous running lifeworld.
EXPLORING THE RELATIONSHIP AMONG ECONOMIC GROWTH, REAL EFFECTIVE EXCHANGE RATE MISALIGNMENT AND EXCHANGE RATE REGIME: CASE OF TUNISIA
Creators: name: LAMIA BENZID
Publisher: name: Zenodo
Year: 2024
Subjects: Economic growth, Exchange rate regime, Misalignment, Real effective exchange rate, Simultaneous-equation modeling strategy.

description: Abstract

This work's aim is to investigate the impact of real effective exchange rate misalignment on Tunisian economic growth while also assessing the exchange rate regime option's impact on misalignment from 1985 to 2021 using a simultaneous-equation modeling strategy. According to the analytical outcomes, misalignment has an adverse effect on economic growth, and it is exacerbated in a fixed exchange rate regime. The structure of a country's exchange rate regime, that is prospective to impact its growth over time, indirectly, via its impact on one of the determinants of growth in the economy, like misalignment, distinguishes this study from earlier studies.
Genetic contributions to generalized arousal of brain and behavior
Creators: name: Frohlich, J.
name: Korach, K. S.
name: Ogawa, S.
name: Gustafsson, J.- A.
name: Morgan, M.
name: Garey, J.
name: Smithies, O.
name: Goodwillie, A.
name: Pfaff, D. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.
Dynamical properties of an exactly solvable coupled quantum double-well system: The evolution speed and entanglement
Creators: name: Hasegawa, Hideo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We have studied dynamical properties of an exactly solvable quantum coupled double-well (DW) systems with Razavy's hyperbolic potential. With the use of four kinds of initial wavepackets, the correlation function $Γ(t)$ and the concurrence $C(t)$ which is a typical measure of the entanglement in two qubits, are calculated. We obtain the orthogonality time $τ$ which signifies a time interval for an initial state to evolve to its orthogonal state, and the temporal average of $C(t)$, $C_{av}$ $(=\sqrt{\langle C(t)^2 \rangle})$. The coupling dependence of $τ$ and the concurrence [$C_{av}$ or $C(0)$], and the relation between $τ$ and the concurrence are investigated. Our calculations have shown that the evolution speed measured by $τ^{-1}$ is not necessarily increased with increasing the concurrence in coupled DW systems.
description: 25 pages, 15 figures; arXiv admin note: text overlap with arXiv:1403.0543; accepted in Physica E with minor revisions
Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae
Creators: name: Dominska, M.
name: Petes, T. D.
name: Mieczkowska, J. O.
name: Mieczkowski, P. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Yeast strains with mutations in both TEL1 and MEC1 have short telomeres and elevated rates of chromosome deletions. By using a PCR assay, we demonstrate that mec1 tel1 strains also have telomere–telomere fusions (T-TFs). T-TFs require Lig4p (a ligase required for nonhomologous end-joining DNA repair). The highest rates of T-TFs are found in strains with combination of mutations that affect telomere length and DNA damage checkpoints (mec1 tel1, mec3 tel1, mre11 mec1, and ddc1 tel1 strains). Examining many mutant genotypes, we find good agreement between the level of T-TFs and the rate of chromosomal deletions. In addition, if telomeres are elongated in a mec1 tel1 strain, we eliminate T-TFs and reduce the deletion rate. The correlation between the level of T-TFs and the rate of deletions argues that many of these deletions reflect a cycle of T-TF formation (resulting in dicentric chromosomes), followed by chromosome breakage.