cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Precision Shock Tuning on the National Ignition Facility
Creators: name: Robey, H. F.
name: Celliers, P. M.
name: Kline, J. L.
name: Mackinnon, A. J.
name: Boehly, T. R.
name: Landen, O. L.
name: Eggert, J. H.
name: Hicks, Damien
name: Le Pape, S.
name: Farley, D. R.
name: Bowers, M. W.
name: Krauter, K. G.
name: Munro, D. H.
name: Jones, O. S.
name: Milovich, J. L.
name: Clark, D.
name: Spears, B. K.
name: Town, R. P. J.
name: Haan, S. W.
name: Dixit, S.
name: Schneider, M. B.
name: Dewald, E. L.
name: Widmann, K.
name: Moody, J. D.
name: Döppner, T. D.
name: Radousky, H. B.
name: Nikroo, A.
name: Kroll, J. J.
name: Hamza, A. V.
name: Horner, J. B.
name: Bhandarkar, S. D.
name: Dzenitis, E.
name: Alger, E.
name: Giraldez, E.
name: Castro, C.
name: Moreno, K.
name: Haynam, C.
name: LaFortune, K. N.
name: Widmayer, C.
name: Shaw, M.
name: Jancaitis, K.
name: Parham, T.
name: Holunga, D. M.
name: Walters, C. F.
name: Haid, B.
name: Malsbury, T.
name: Trummer, D.
name: Coffee, K. R.
name: Burr, B.
name: Berzins, L. V.
name: Choate, C.
name: Brereton, S. J.
name: Azevedo, S.
name: Chandrasekaran, H.
name: Glenzer, S.
name: Caggiano, J. A.
name: Knauer, J. P.
name: Frenje, J. A.
name: Casey, D. T.
name: Gatu Johnson, M.
name: Séguin, F. H.
name: Young, B. K.
name: Edwards, M. J.
name: Van Wonterghem, B. M.
name: Kilkenny, J.
name: MacGowan, B. J.
name: Atherton, J.
name: Lindl, J. D.
name: Meyerhofer, D. D.
name: Moses, E.
Publisher: name: Swinburne
Year: 2024

description: Ignition implosions on the National Ignition Facility [J. D. Lindl et al., Phys. Plasmas 11, 339 (2004)] are underway with the goal of compressing deuterium-tritium fuel to a sufficiently high areal density (ρR) to sustain a self-propagating burn wave required for fusion power gain greater than unity. These implosions are driven with a very carefully tailored sequence of four shock waves that must be timed to very high precision to keep the fuel entropy and adiabat low and ρR high. The first series of precision tuning experiments on the National Ignition Facility, which use optical diagnostics to directly measure the strength and timing of all four shocks inside a hohlraum-driven, cryogenic liquid-deuterium-filled capsule interior have now been performed. The results of these experiments are presented demonstrating a significant decrease in adiabat over previously untuned implosions. The impact of the improved shock timing is confirmed in related deuterium-tritium layered capsule implosions, which show the highest fuel compression (ρR∼1.0  g/cm2) measured to date, exceeding the previous record [V. Goncharov et al., Phys. Rev. Lett. 104, 165001 (2010)] by more than a factor of 3. The experiments also clearly reveal an issue with the 4th shock velocity, which is observed to be 20% slower than predictions from numerical simulation.
Glimpsing mirrors
Creators: name: Bennett, Madison
Publisher: name: University of Iowa
Year: 2022
Subjects: book arts
book history
calligraphy
manuscript
palimpsest
parchment
public abstract

description: Glimpsing Mirrors is a multi-year project through which I explored the traditional craft of parchment making and leveraged my 12 years of calligraphy experience to create contemporary palimpsests. In manuscript studies, a palimpsest refers to a page that features several layers of effaced writing. In other words, a historical palimpsest is the unintentional result of recycling parchment (a valuable material made of stretched and dried animal skin) or censoring text. This essay serves as a catalog of the 14 pieces featured in my MFA thesis exhibition. The work examines the materiality of parchment and the metaphorical nature of palimpsests as creations of layers that are built up and broken down over time.
MRI-based diagnostic biomarkers for early onset pediatric multiple sclerosis
Creators: name: Weygandt, Martin
name: Hummel, Hannah-Maria
name: Schregel, Katharina
name: Ritter, Kerstin
name: Allefeld, Carsten
name: Dommes, Esther
name: Huppke, Peter
name: Haynes, John-Dylan
name: Wuerfel, Jens
name: Gaertner, Jutta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Pediatric multiple sclerosis
subject: Early onset pediatric multiple sclerosis
subject: Biomarkers
subject: Diagnostic information
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Currently, it is unclear whether pediatric multiple sclerosis (PMS) is a pathoetiologically homogeneous disease phenotype due to clinical and epidemiological differences between early and late onset PMS (EOPMS and LOPMS). Consequently, the question was raised whether diagnostic guidelines need to be complemented by specific EOPMS markers. To search for such markers, we analyzed cerebral MRI images acquired with standard protocols using computer-based classification techniques. Specifically, we applied classification algorithms to gray (GM) and white matter (WM) tissue probability parameters of small brain regions derived from T2-weighted MRI images of EOPMS patients (onset <12 years), LOPMS patients (onset ≥12 years), and healthy controls (HC). This was done for PMS subgroups matched for disease duration and participant age independently. As expected, maximal diagnostic information for distinguishing PMS patients and HC was found in a periventricular WM area containing lesions (87.1% accuracy, p < 2.2 × 10−5). MRI-based biomarkers specific for EOPMS were identified in prefrontal cortex. Specifically, a coordinate in middle frontal gyrus contained maximal diagnostic information (77.3%, p = 1.8 × 10−4). Taken together, we were able to identify biomarkers reflecting pathognomonic processes specific for MS patients with very early onset. Especially GM involvement in the separation between PMS subgroups suggests that conventional MRI contains a richer set of diagnostically informative features than previously assumed.
The identity and diversity of attributes in the absolute idealism of Spinoza.
Creators: name: Thomas, James A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1989
Subjects: subject: Philosophy.

description: The issue addressed in this thesis is one in the absolute idealism of Spinoza. It is one of specifying an interpretation of substance-attribute identity as a solution to the problem of reconciling it with the diversity of the attributes and the oneness of substance. As a testing ground for any proposed solution, a list of questions is generated. Given the countable diversity of the attributes, can we conceive of the identity of each of them with the one substance? Why, if I am identical to a mode of each of infinite attributes, do I perceive only a body? What is the rational explanation for the infinite countable diversity of the attributes and our being directly acquainted with only two? In what manner can we reconcile the divisibility of substance with the activity of thought? How does one reconcile the order of extension seeming to be one of external relations with the essentially internal order of any finite thinking thing? How does one reconcile the independent being of modes of extension with the truth-functionality of ideas? In what manner is it possible to understand the appearance of the uniqueness of the one thing conceived under the idea of the body and the one-among-severalness of the same thing conceived under the idea of the individual's mind? In what manner can it be said that substance, consisting of infinite attributes, is accurately and completely conceived through any one of them while each is conceptually independent of every other? How can the one thing which is mind and body be wholly and accurately conceived to be a mode of either of their respective attributes while modes of differing attributes are also conceptually independent? The interpretations of substance-attribute identity given by John Clark Murray, T. L. S. Sprigge, and Errol E. Harris, in their writings in which they advocate reading Spinoza as an absolute idealist, are argued to be disadvantageous in dealing with the evident parallelism of the attributes. Finally, a proposed solution, offered by an alternative absolute idealist interpretation of substance-attribute identity, is developed in response to each of the above questions.
Insulin signaling in heart failure
Creators: name: Autenried, Rebecca Katharine
Publisher: name: University of Iowa
Year: 2022
Subjects: Human Cardiac Tissue
Insulin Signaling
Interdisciplinary
Western Blot
Medicine
public abstract
Diabetes
Heart Failure

description: Insulin is the hormone released by the pancreas following the consumption of a meal containing carbohydrates and allows for the carbohydrates to enter into and power the necessary functions of the cells of the organs of the body. In diseases like diabetes, the ability of insulin to have its necessary function is out of balance which can cause other health problems including diseases of the heart. Since a lot of people are developing diabetes there is a global demand for improved ways to manage the disease. Basic science allows for new knowledge to be developed on which clinical treatments of the future can be designed. Through studying human heart tissue samples, genetic mouse models of disease, and the development of new tools at the molecular level, the author has built the foundation to be able to make a meaningful contribution to the field of translational endocrinology. The main scholarly contribution of this work is a molecular level understanding of insulin signaling in the end-stage failing human heart. Oftentimes after someone experiences a heart attack, their heart’s ability to function is chronically impaired and progresses to failure which can be fatal. The only way to treat heart failure is through transplanting a functional heart from a donor into a recipient. The removed failing hearts from transplant recipients were studied for differences in insulin signaling at the molecular level and several key findings were made that differed from insulin signaling in non-failing donor hearts.
Interaction of HPA axis genetics and early life stress shapes emotion recognition in healthy adults
Creators: name: Hartling, Corinna
name: Fan, Yan
name: Weigand, Anne
name: Trilla, Irene
name: Gärtner, Matti
name: Bajbouj, Malek
name: Dziobek, Isabel
name: Grimm, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: early life stress
subject: HPA axis
subject: G-x-E-interaction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Early life stress (ELS) affects facial emotion recognition (FER), as well as the underlying brain network. However, there is considerable inter-individual variability in these ELS-caused alterations. As the hypothalamic-pituitary-adrenal (HPA) axis is assumed to mediate neural and behavioural sequelae of ELS, the genetic disposition towards HPA axis reactivity might explain differential vulnerabilities. Methods: An additive genetic profile score (GPS) of HPA axis reactivity was built from 6 SNPs in 3 HPA axisrelated genes (FKBP5, CRHR1, NR3C1). We studied two independent samples. As a proof of concept, GPS was tested as a predictor of cortisol increase to a psychosocial challenge (MIST) in a healthy community sample of n=40. For the main study, a sample of n=170 completed a video-based FER task and retrospectively reported ELS experiences in the Childhood Trauma Questionnaire (CTQ). Results: GPS positively predicted cortisol increase in the stress challenge over and above covariates. CTQ and genetic profile scores interacted to predict facial emotion recognition, such that ELS had a detrimental effect on emotion processing only in individuals with higher GPS. Post-hoc moderation analyses revealed that, while a less stress-responsive genetic profile was protective against ELS effects, individuals carrying a moderate to high GPS were affected by ELS in their ability to infer emotion from facial expressions. Discussion: These results suggest that a biologically informed genetic profile score can capture the genetic disposition to HPA axis reactivity and moderates the influence of early environmental factors on facial emotion recognition. Further research should investigate the neural mechanisms underlying this moderation. The GPS used here might prove a powerful tool for studying inter-individual differences in vulnerability to early life stress.
A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia
Creators: name: Leroy, Sandrine
name: Caumette, Elsa
name: Waddington, Chandra
name: Hébert, Audrey
name: Brant, Rollin
name: Lavoie, Pascal M.
Publisher: name: National Library of Medicine
Year: 2024

description: Objective: To precisely delineate the timing and contribution of inflammation to bronchopulmonary dysplasia (BPD) in preterm infants during the neonatal period. Study Design: Longitudinal study of blood inflammatory biomarkers (IL-6, IL-8 and GCSF) measured between birth and 42 days of age, at high temporal (daily) resolution, in infants born at or below 30 weeks of gestation. Cytokine predictors of BPD at 36 weeks post-menstrual age were adjusted for infant-specific and time-dependent factors, using hierarchical mixed effects regressions models. Results: A total of 1518 data points were obtained in 62 infants (mean GA 27 weeks). Infants who developed BPD later on presented increased inflammation after birth compared to infants without BPD. Inflammation was sustained, with gradual attenuation over three weeks (IL-8: OR: 6.5 [95%CI: 1.8 – 24]; GCSF: 3.3 [1.5 – 7.6]) and was higher in boys and in infants of lower birth weight. This inflammation preceded the clinical increased requirement in supplemental oxygen characteristic of BPD, and preceded the peak occurrence of neonatal sepsis or necrotizing enterocolitis. Conclusion: Systemic inflammation occurs early in the neonatal period and precedes clinical symptoms in infants with BPD. These data provide a discrete vulnerability window period, supporting a role for targeted intensive care interventions during the early phase of BPD.
title: The z-expansion
title: applications in particle decay and scattering processes
titleType: Subtitle
Creators: name: Simons, Daniel
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: The z-expansion is an exciting mathematical tool that has been used to study a variety of different particle decay and scattering events over the last few decades. The decay rates and scattering cross sections are functions of objects called form factors, which can be described by the z-expansion. The z-expansion is only a function of the particle momentum transfer. I will show its application in two independent investigations: in the vector form factor that appears in B meson decays and in the axial form factor that appears in neutrino-nucleon scattering.
description: For B meson decays, we investigate two different parameterizations of the vector form factor that both use the z-expansion. By fitting these parameterizations to experimental data collected by the Belle collaboration, we are able to determine the goodness of the fit and the self-consistency of each parameterization with differing numbers of free parameters. This will be useful for future lattice QCD simulations that only have manageable uncertainties in a small range of momentum transfer values.
description: For neutrino scattering, we investigate the historical dipole ansatz for the axial form factor which does not involve the z-expansion and the more modern description of the axial form factor with the z-expansion. By using the results of external z-expansion fits, we are able to determine a quantitative description of how the uncertainties in the axial form factor propagates into the scattering cross section. This will be useful for future neutrino oscillation experiments which require extremely high precision cross section calculations.
Studies of blood monocytes from patients infected with the human immunodeficiency virus-1 (HIV-1).
Creators: name: Shen, Yuenan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Health Sciences, Immunology.

description: To determine if blood monocytes from HIV-1 seropositive patients contain HIV-1 antigen and genome, we separated monocytes and T cell subsets using monoclonal antibodies (mAbs) conjugated to magnetic beads and by monocyte adherence to glass. We found: (1) Monocytes cultured without depletion of CD4$\sp+$ T cells (11 of 11 patients) were HIV-1 antigen positive and showed dramatically increased spontaneous formation of MGCs. (2) Monocytes cultured after depletion of CD4$\sp+$ T cells (3 experiments) were HIV-1 antigen negative and MGC formation was markedly decreased. (3) In 14 subsequent patients analyzed by PCR, all patients were positive for HIV-1 proviral DNA in cells enriched for CD4$\sp+$ T cells. In 11 of 14 patients (79%), the monocyte fractions were HIV-1 proviral DNA negative, while in the remaining 3 patients, the monocytes were positive for HIV-1 proviral DNA. In conclusion, the major reservoir for HIV-1 infection in human peripheral blood is CD4$\sp+$ T cells (14 of 14 cases). Fresh blood monocytes from HIV-1 seropositive patients were HIV-1 proviral DNA negative in 11 of 14 cases (79%). Blood monocyte-derived macrophages from HIV-1 seropositive patients may acquire HIV-1 infection in vitro from contaminating infected CD4$\sp+$ T cells. The pathogenic and clinical significance of HIV-1 infected monocytes (21% of patients) remains to be determined. (Abstract shortened by UMI.)
Herschel -ATLAS: Blazars in the science demonstration phase field
Creators: name: González-Nuevo, J.
name: De Zotti, G.
name: Andreani, P.
name: Barton, E. J.
name: Bertoldi, F.
name: Birkinshaw, M.
name: Bonavera, L.
name: Buttiglione, S.
name: Cooke, Jeff
name: Cooray, A.
name: Danese, G.
name: Dunne, L.
name: Eales, S.
name: Fan, L.
name: Jarvis, M. J.
name: Klöckner, H.-R.
name: Hatziminaoglou, E.
name: Herranz, D.
name: Hughes, D. H.
name: Lapi, A.
name: Lawrence, A.
name: Leeuw, L.
name: Lopez-Caniego, M.
name: Massardi, M.
name: Mauch, T.
name: Michałowski, M. J.
name: Negrello, M.
name: Rawlings, S.
name: Rodighiero, G.
name: Samui, S.
name: Serjeant, S.
name: Vieira, J. D.
name: White, G.
name: Amblard, A.
name: Auld, R.
name: Baes, M.
name: Bonfield, D. G.
name: Burgarella, D.
name: Cava, A.
name: Clements, D. L.
name: Dariush, A.
name: Dye, S.
name: Frayer, D.
name: Fritz, J.
name: Ibar, E.
name: Ivison, R. J.
name: Lagache, G.
name: Maddox, S.
name: Pascale, E.
name: Pohlen, M.
name: Rigby, E.
name: Sibthorpe, B.
name: Smith, D. J. B.
name: Temi, P.
name: Thompson, M.
name: Valtchanov, I.
name: Verma, A.
Publisher: name: Swinburne
Year: 2024

description: To investigate the poorly constrained sub-mm counts and spectral properties of blazars we searched for these in the Herschel-ATLAS (H-ATLAS) science demonstration phase (SDP) survey catalog. We cross-matched 500 μm sources brighter than 50 mJy with the FIRST radio catalogue. We found two blazars, both previously known. Our study is among the first blind blazar searches at sub-mm wavelengths, i.e., in the spectral regime where little is still known about the blazar SEDs, but where the synchrotron peak of the most luminous blazars is expected to occur. Our early results are consistent with educated extrapolations of lower frequency counts and question indications of substantial spectral curvature downwards and of spectral upturns at mm wavelengths. One of the two blazars is identified with a Fermi/LAT γ-ray source and a WMAP source. The physical parameters of the two blazars are briefly discussed. These observations demonstrate that the H-ATLAS survey will provide key information about the physics of blazars and their contribution to sub-mm counts.
The potentiating effects of neuropeptide Y on vascular smooth muscle.
Creators: name: Small, Daniel L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Animal Physiology.

description: In the present study, the roles of nifedipine-sensitive calcium channels and the endothelium in the potentiating effect of neuropeptide Y (NPY) in the rat tail artery were investigated. Contractile responses to KCl, $\alpha,\beta$-methylene ATP (mATP), and NA were compared. KCl- and mATP-induced vasoconstriction is closely linked to nifedipine-sensitive calcium channels while NA-induced vasoconstriction is not. The role of the endothelium in potentiating effects of NPY was also tested by comparing intact arterial ring segments with denuded arterial ring segments. Freshly isolated single smooth muscle cells in which the influences of the endothelium and the nerves were unequivocally eliminated were examined to verify the results of the ring segments. Contractile responses to KCl and mATP were potentiated by NPY (50 nM) while NA responses were not potentiated at 50 nM but were at 500 nM NPY. The potentiating effect of NPY was antagonized by nifedipine. The intact and denuded arteries responded similarly. The shortening of single smooth muscle cells in response to KCl and mATP was potentiated by NPY (50 nM) while the noradrenaline response was potentiated by NPY at 500 nM but not at 50 nM. (Abstract shortened by UMI.)
Screening the baseline fish bioconcentration factor of various types of surfactants using phospholipid binding data
Creators: name: Droge, Steven T. J.
name: Scherpenisse, Peter
name: Arnot, Jon A.
name: Von Der Ohe, Peter C.
Publisher: name: My University
Year: 2021

description: Fish bioconcentration factors (BCFs) are commonly used in chemical hazard and risk assessment. For neutral organic chemicals BCFs are positively correlated with the octanol-water partition ratio (KOW), but KOW is not a reliable parameter for surfactants. Membrane lipid-water distribution ratios (DMLW) can be accurately measured for all kinds of surfactants, using phospholipid-based sorbents. This study first demonstrates that DMLW values for ionic surfactants are more than 100â€č000 times higher than the partition ratio to fish-oil, representing neutral storage lipid. A non-ionic alcohol ethoxylate surfactant showed almost equal affinity for both lipid types. Accordingly, a baseline screening BCF value for surfactants (BCFbaseline) can be approximated for ionic surfactants by multiplying DMLW by the phospholipid fraction in tissue, and for non-ionic surfactants by multiplying DMLW by the total lipid fraction. We measured DMLW values for surfactant structures, including linear and branched alkylbenzenesulfonates, an alkylsulfoacetate and an alkylethersulfate, bis(2-ethylhexyl)-surfactants (e.g., docusate), zwitterionic alkylbetaines and alkylamine-oxides, and a polyprotic diamine. Together with sixty previously published DMLW values for surfactants, structure-activity relationships were derived to elucidate the influence of surfactant specific molecular features on DMLW. For 23 surfactant types, we established the alkyl chain length at which BCFbaseline would exceed the EU REACH bioaccumulation (B) threshold of 2000 L kg-1, and would therefore require higher tier assessments to further refine the BCF estimate. Finally, the derived BCFbaseline are compared with measured literature in vivo BCF data where available, suggesting that refinements, most notably reliable estimates of biotransformation rates, are needed for most surfactant types. © Royal Society of Chemistry 2021
title: Translating young adult fiction
title: the good, the bad and the scary
titleType: Subtitle
Creators: name: Beauchamp, Madi
Publisher: name: University of Iowa
Year: 2025
Subjects: Celle Qui Marche La Nuit
Delphine Bertholon
English Language Arts
French
Young Adult Fiction
public abstract
Translation

description: Delphine Bertholon (1976-) is a writer of novels and screenplays from Lyon, France. Her novel 'Celle qui marche la nuit' or 'The One that Walks at Night' was published in 2019 and is an award- winning young adult thriller told through the diary of 15-year-old boy, Malo. This story explores themes of grief, change and fear. This translation is accompanied by a paratext as well as sample discussion questions for a demonstration of the potential of teaching translated texts into American English Language Arts classrooms.
The Cosmopolitan Club movement at the University of Iowa
Creators: name: Schwarz, Molly J
Publisher: name: University of Iowa
Year: 2024

description: The Cosmopolitan Club Movement began at the University of Wisconsin in 1903. By 1907, eight universities joined the Wisconsin club to form a national association called the Association of Cosmopolitan Clubs (ACC). In 1908, at the State University of Iowa (SUI) a cohort of engineering students from the Philippines and Mexico began the State University of Iowa Cosmopolitan Club (SUI CC) and joined the ACC. By 1913, when the SUI hosted the Seventh Annual National ACC Convention in Iowa City, thirty chapters belonged to the ACC.
description: In the early twentieth century, Cosmopolitan Clubs provided opportunities for foreign and domestic students to work toward internationalism on university campuses. The ACC pioneered foreign student support systems and outreach in US higher education, leading to the implementation of foreign student advisors on college campuses and governmental handbooks to assist international students in navigating the US higher education system.
description: Specifically looking at the SUI CC, my research illuminates the interactions among Cosmopolitan Club international student members, fellow domestic students, SUI faculty, SUI administration, and residents of Iowa City. In addition, I examine the role of Sudhindra Bose, a key figure within the local and national Cosmopolitan Club Movement. More broadly, I examine the Cosmopolitan Club Movement at the national level, arguing that despite challenges faced by the national association, at the local level, the foreign student members of the SUI CC and Sudhindra Bose played key roles in laying the foundation for dynamic international exchange and began a legacy of internationalism at SUI.
title: Überprüfung der Eignung reaktiver Methacrylatklebstoffe für die Restaurierung musealer Steinobjekte
Creators: name: Pung, Olaf
Publisher: name: HAWK Hildesheim/Holzminden/Göttingen
Year: 2000
Subjects: Conservation science

description: Heute sind in der Steinrestaurierung hauptsächlich Reaktionsklebstoffe auf Epoxid- und Polyesterbasis gebräuchlich. Die Tatsache, daß diese Klebstoffe die in der Restaurierung allgemein gestellte Forderung nach Reversibilität nicht erfüllen, war Ausgangspunkt dieser Arbeit. Eine Alternative bieten gewisse Reaktionsharze auf der Basis von Methylmethacrylat (MMA): Diese besitzen zwar die Vorteile eines Reaktionsklebstoffes, durch die Härtungsreaktion entsteht jedoch kein duromerer Kunststoff wie bei Epoxid oder Polyester, sondern der thermoplastische Kunststoff Polymethylmethacrylat (PMMA). Dieser läßt sich durch Erwärmung oder mittels organischer Lösungsmittel wie Aceton erweichen, wodurch eine solche Klebung leichter wieder zu trennen ist.
Die Arbeit erbrachte folgende Ergebnisse: Reaktive MMA-Klebstoffe ohne vernetzende Zusätze sind grundsätzlich geeignet für die Verklebung musealer Steinobjekte. Problematisch sind die geringe Topfzeit sowie die schlechtere Adhäsion im Vergleich zu Epoxidharzen. Die Langzeitbeständigkeit der Klebstoffe ist hervorragend. Es ist zu erwarten, daß über einen längeren Zeitraum weder Schrumpfung, Degradation oder Verlust der Löslichkeit auftreten. Auf dem Markt konnten keine MMA-Reaktionsharze gefunden werden, die explizit als Klebstoffe gedacht sind und die Forderung nach Wiederanlösbarkeit erfüllen. Es gibt zwar zwei Gießharze mit den geforderten Eigenschaften, das Verarbeitungssystem dieser Produkte ist jedoch für eine Anwendung als Klebstoff weniger geeignet. Eines der selbstformulierten Produkte besitzt hier bessere Eigenschaften.
The Detection of a Population of Submillimeter-Bright, Strongly Lensed Galaxies
Creators: name: Negrello, M.
name: Hopwood, R.
name: De Zotti, G.
name: Cooray, A.
name: Verma, A.
name: Bock, J. J.
name: Frayer, D. T.
name: Gurwell, Mark A.
name: Omont, A.
name: Neri, R.
name: Dannerbauer, H.
name: Leeuw, L.
name: Barton, Elizabeth J.
name: Cooke, Jeff
name: Kim, S.
name: Lima Da Cunha, Elisabete
name: Rodighiero, G.
name: Cox, P.
name: Bonfield, D. G.
name: Jarvis, M. J.
name: Serjeant, S.
name: Ivison, R. J.
name: Dye, S.
name: Aretxaga, I.
name: Hughes, D. H.
name: Ibar, E.
name: Bertoldi, F.
name: Valtchanov, I.
name: Eales, S. A.
name: Dunne, L.
name: Driver, S. P.
name: Auld, R.
name: Buttiglione, S.
name: Cava, A.
name: Grady, C. A.
name: Clements, D. L.
name: Dariush, A.
name: Fritz, J.
name: Hill, D.
name: Hornbeck, J. B.
name: Kelvin, L.
name: Lagache, G.
name: Lopez-Caniego, M.
name: González-Nuevo, J.
name: Maddox, S.
name: Pascale, E.
name: Pohlen, M.
name: Rigby, E. E.
name: Robotham, A.
name: Simpson, C.
name: Smith, D. J. B.
name: Temi, P.
name: Thompson, M. A.
name: Woodgate, B. E.
name: York, D. G.
name: Aguirre, J. E.
name: Beelen, A.
name: Blain, A. W.
name: Baker, A. J.
name: Birkinshaw, M.
name: Blundell, R.
name: Bradford, C. M.
name: Burgarella, D.
name: Danese, L.
name: Dunlop, J. S.
name: Fleuren, S.
name: Glenn, J.
name: Harris, A. I.
name: Kamenetzky, J.
name: Lupu, R. E.
name: Maddalena, R. J.
name: Madore, Barry F.
name: Maloney, P. R.
name: Matsuhara, H.
name: Michaowski, M. J.
name: Murphy, E. J.
name: Naylor, B. J.
name: Nguyen, H. T.
name: Popescu, C.
name: Rawlings, Steve
name: Rigopoulou, D.
name: Scott, Douglas
name: Scott, K. S.
name: Seibert, Mark
name: Smail, I.
name: Tuffs, R. J.
name: Vieira, J. D.
name: van der Werf, P.
name: Zmuidzinas, J.
Publisher: name: Swinburne
Year: 2024

description: Gravitational lensing is a powerful astrophysical and cosmological probe and is particularly valuable at submillimeter wavelengths for the study of the statistical and individual properties of dusty star-forming galaxies. However, the identification of gravitational lenses is often time-intensive, involving the sifting of large volumes of imaging or spectroscopic data to find few candidates. We used early data from the Herschel Astrophysical Terahertz Large Area Survey to demonstrate that wide-area submillimeter surveys can simply and easily detect strong gravitational lensing events, with close to 100% efficiency.
Preserved partner-specific audience design in multiparty conversation in people with Parkinson’s disease
Creators: name: Woepking, Mallory M.
Publisher: name: University of Iowa
Year: 2023
Subjects: subject: audience design
subject: cognition
subject: multiparty
subject: Parkinson's
subject: social communication
subject: virtual modality
subject: Linguistics
subject: FOS: Languages and literature
subject: public abstract

description: Social communication is vital to everyday human interaction. One facet of social communication skills highlights the ability to adapt language to reflect the knowledge state of a given audience. This process is called audience design. To demonstrate this skill, a speaker must acknowledge their conversational partner’s level of familiarity with the topic of focus. If we are speaking to someone who is less familiar with a given topic, we use more extensive language to bridge the gap of understanding. The opposite is true for someone who we recognize as more familiar with the topic of interest.
description: People with Parkinson’s disease (PwPD) demonstrate motor and non-motor symptoms. While most of PD research and treatment targets motor symptoms, our focus is on the growing body of literature concerning cognition and language in PwPD. The preliminary study found that PwPD have intact audience design when speaking with one partner over the virtual modality. The current study aims to generalize these findings to face-to-face conversations. Furthermore, this is the first study to look at the language production of PwPD in multiparty conversation.
description: Expression length and referential expression (article) type were measured during a communication task in which PwPD described abstract images to a familiar partner, unfamiliar partner, or both (multiparty setting). No significant difference between PD and healthy controls was found, suggesting that PwPD demonstrate intact audience design at the multiparty conversational level. An exploratory analysis comparing the preliminary versus current study suggests that PwPD may be more sensitive to the downfalls of virtual communication. This is a topic that should be studied further. Overall, the study is an initial step in understanding the ability of PwPD to adapt language during social interactions with one or more people.
Structural properties of one-tape Turing machines.
Creators: name: Lin, Jack Chen-Hung.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Computer Science.

description: The model of Turing machines has been studied since its birth in 1936. Researchers have continuously proposed variants of such a model. Upon imposing different constraints, the power of each model varies or even remains the same, accordingly. Some well-known result (for example, the equivalence of finite state automata and one-tape linear-time deterministic Turing machines) has proven that the abilities of overwriting the tape content and scanning the tape content more than once cannot gain any advantage under certain restrictions. In this thesis, we study the behaviors and the fundamental properties of variants of one-tape Turing machines, such as deterministic, reversible, nondeterministic, probabilistic, and quantum Turing machines. This gives us a better understanding about the strength and the weakness of each machine type. For example, under the one-tape linear-time restriction, reversible, nondeterministic, co-nondeterministic, and bounded-error probabilistic computations recognize exactly regular languages whereas probabilistic and quantum Turing machines can recognize even non-regular languages.
PTF10ops - a subluminous, normal-width light curve Type Ia supernova in the middle of nowhere
Creators: name: Maguire, K.
name: Sullivan, M.
name: Thomas, R. C.
name: Nugent, P.
name: Howell, D. A.
name: Gal-Yam, A.
name: Arcavi, I.
name: Ben-Ami, S.
name: Blake, S.
name: Botyanszki, J.
name: Buton, C.
name: Cooke, Jeff
name: Ellis, R. S.
name: Hook, I. M.
name: Kasliwal, M. M.
name: Pan, Y.-C.
name: Pereira, R.
name: Podsiadlowski, P.
name: Sternberg, A.
name: Suzuki, N.
name: Xu, D.
name: Yaron, O.
name: Bloom, J. S.
name: Cenko, S. B.
name: Kulkarni, S. R.
name: Law, N.
name: Ofek, E. O.
name: Poznanski, D.
name: Quimby, R. M.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: PTF10ops is a Type Ia supernova (SN Ia), whose light curve and spectral properties place it outside the current SN Ia subtype classifications. Its spectra display the characteristic lines of subluminous SNe Ia, but it has a normal-width light curve with a long rise time, typical of normal-luminosity SNe Ia. The early-time optical spectra of PTF10ops were modelled using a spectral fitting code and found to have all the lines typically seen in subluminous SNe Ia, without the need to invoke more uncommon elements. The host galaxy environment of PTF10ops is also unusual with no galaxy detected at the position of the SN down to an absolute limiting magnitude of r≥−12.0 mag, but a very massive galaxy is present at a separation of ∼148 kpc and at the same redshift as suggested by the SN spectral features. The progenitor of PTF10ops is most likely a very old star, possibly in a low-metallicity environment, which affects its explosion mechanism and observational characteristics. PTF10ops does not easily fit into any of the current models of either subluminous or normal SN Ia progenitor channels.
Supportive communication processes of caregivers involved in the child welfare system
Creators: name: Conrad, Jordan B.
Publisher: name: University of Iowa
Year: 2023
Subjects: Support discrepancies
Supportive communication
Child Welfare

description: This study aims to examine the unique perspective of caregivers who have lost custody of their children due to maltreatment, focusing on their experiences with supportive communication from caseworkers in the child welfare system. Previous research has overlooked the caregiver's viewpoint and their communication with caseworkers, limiting our understanding of their support needs. To address this gap, optimal matching models and support gap theories were utilized to explore the types and amounts of supportive communication desired by caregivers and the associated outcomes related to the support they receive. Furthermore, this study introduces and empirically tests the concept of communicative advocacy support, a form of support that involves triangulated communication between three or more individuals.
description: Contrary to previous studies, which suggested a preference for emotional support, the findings indicate that caregivers in this context express a preference for action-facilitated types of support from caseworkers. Additionally, significant discrepancies between desired and received support were reported, highlighting the unique support expectations and desires of caregivers. Importantly, the results reveal that caregivers generally desire more support than they receive across various contexts.
description: Moreover, this study illuminates the complex and sometimes counterintuitive impact of being under or over-benefitted in support of relational, emotional, and behavioral outcomes for caregivers. Lastly, the study contributes to existing supportive communication theory by introducing advocacy support as a distinct support type. Caregivers expect and desire advocacy support from caseworkers but often feel undersupported in this area. These findings emphasize the importance of prioritizing caregiver perspectives in child welfare research and practice, underscoring the need for further investigation into their unique support needs.
Fighting words: Trauma and re-covery in/and the discourses of Pugilism.
Creators: name: Conway, Brett Alan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Anthropology, Cultural.

description: This thesis applies trauma theory to three boxing genres: autobiography, fiction, and film, respectively. I examine boxing, a sport that puts the male body on display, as being constitutionally split between sadism and masochism, masculinity and femininity. I argue that boxing culture, as well as the culture beyond the ring, attempts to overcome the fragmentation, the trauma, that results from this division by identifying with the winning, not the losing, boxer, thereby reintrenching the myth of male presence; however, by examining David Savran's and Kaja Silverman's theories of male subjectivity as well as Joyce Carol Oates's On Boxing, I demonstrate that what we call "male presence" is really a cover for "male absence." In the conclusion, therefore, I argue that Muhammad Ali, rather than asserting a re-covery from trauma, attests to the trauma at the heart of male subjectivity, thereby undermining male presence, what Kaja Silverman calls the "dominant fiction."
Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells
Creators: name: Buckley, Alysia G.
name: Looi, Kevin
name: Iosifidis, Thomas
name: Ling, Kak-Ming
name: Sutanto, Erika N.
name: Martinovich, Kelly M.
name: Kicic-Starcevich, Elizabeth
name: Garratt, Luke W.
name: Shaw, Nicole C.
name: Lannigan, Francis J.
name: Larcombe, Alexander N.
name: Zosky, Graeme
name: Knight, Darryl
name: Rigby, Paul J.
name: Kicic, Anthony
name: Stick, Stephen M.
Publisher: name: BioMed Central
Year: 2018

description: Background: Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. Alterations in their expression may lead to disruptions in barrier integrity, which subsequently facilitates entry of potential bacterial and other pathogens into the host. Furthermore, there is emerging evidence that the barrier integrity of the airway in certain airway inflammatory diseases may be altered. However, there is little consensus on the way this is assessed and measured and the type of cells used to achieve this. Methods: Here, we assessed four fixation methods including; (i) 4% (v/v) paraformaldehyde; (ii) 100% methanol; (iii) acetone or; (iv) 1:1 methanol: acetone. Pre-extraction with Triton X-100 was also performed and assessed on cells prior to fixation with either methanol or paraformaldehyde. Cells were also permeabilized with 0.1% (v/v) Saponin in 1× TBS following fixation and subsequently stained for tight junction proteins. Confocal microscopy was then used to visualise, compare and evaluate staining intensity of the tight junctional complexes in order to determine a standardised workflow of reproducible staining. Results: Positive staining was observed following methanol fixation for claudin-1 and ZO-1 tight junction proteins but no staining was detected for occludin in 16HBE14o- cells. Combinatorial fixation with methanol and acetone also produced consistent positive staining for both occludin and ZO-1 tight junction proteins in these cells. When assessed using primary cells cultured at air-liquid interface, similar positive staining for claudin-1 and ZO-1 was observed following methanol fixation, while similar positive staining for occludin and ZO-1 was observed following the same combinatorial fixation with methanol and acetone. Conclusions: The present study demonstrates the importance of a personalised approach to optimise staining for the visualisation of different tight junction proteins. Of significance, the workflow, once optimised, can readily be translated into primary airway epithelial cell air-liquid interface cultures where it can be used to assess barrier integrity in chronic lung diseases.
3603285.pdf
Creators: name: Yao, C
name: Jia, Zhixu
name: Li, Zhenrui
name: Jia, Shijie
name: Zhao, Zhipeng
name: Zhang, Lei
name: Feng, Yan
name: Qin, Guanshi
name: Ohishi, Yasutake
name: Qin, WP
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
GPCR-SSFE 2.0—a fragment-based molecular modeling web tool for Class A G-protein coupled receptors
Creators: name: Worth, Catherine L.
name: Kreuchwig, Franziska
name: Tiemann, Johanna K. S.
name: Kreuchwig, Annika
name: Ritschel, Michele
name: Kleinau, Gunnar
name: Hildebrand, Peter W.
name: Krause, Gerd
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: helix (snails)
subject: g-protein-coupled receptors
subject: fingerprints
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: G-protein coupled receptors (GPCRs) are key players in signal transduction and therefore a large proportion of pharmaceutical drugs target these receptors. Structural data of GPCRs are sparse yet important for elucidating the molecular basis of GPCR-related diseases and for performing structure-based drug design. To ameliorate this problem, GPCR-SSFE 2.0 (http://www.ssfa- 7tmr.de/ssfe2/), an intuitive web server dedicated to providing three- dimensional Class A GPCR homology models has been developed. The updated web server includes 27 inactive template structures and incorporates various new functionalities. Uniquely, it uses a fingerprint correlation scoring strategy for identifying the optimal templates, which we demonstrate captures structural features that sequence similarity alone is unable to do. Template selection is carried out separately for each helix, allowing both single- template models and fragment-based models to be built. Additionally, GPCR-SSFE 2.0 stores a comprehensive set of pre-calculated and downloadable homology models and also incorporates interactive loop modeling using the tool SL2, allowing knowledge-based input by the user to guide the selection process. For visual analysis, the NGL viewer is embedded into the result pages. Finally, blind-testing using two recently published structures shows that GPCR-SSFE 2.0 performs comparably or better than other state-of-the art GPCR modeling web servers.
The molecular cloning, cellular expression, and functional study of human caveolin-1.
Creators: name: Links, Philip Harold.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Molecular.

description: This thesis will discuss the molecular cloning, cellular expression, and functional study of human caveolin-1. This 21 kDa inter-membrane protein is found in cell surface invaginations termed caveolae (Gk: little caves). The expression of caveolin-1 has been shown to be sufficient to form caveolae in cell culture. Caveolin-1 was cloned from human adipose tissue by RT-PCR, sequenced and subcloned into vectors for its eukaryotic over-expression. The eukaryotic expression vectors contained either myc or myc and poly-histidine epitopes to assist in purification. Vectors containing antisense caveolin-1 and a ribozyme targeting caveolin-1 were also created for the targeted disruption of caveolin-1. Caveolin-1 cDNA was transfected into McA-RH7777 rat hepatoma cells, human fibroblasts, human umbilical vein endothelial cells (HUVEC), and Cos-7 cells to evaluate candidate cell lines for stable expression models. Stable cell lines over expressing caveolin-1 were generated in McA-RH7777 and HUVEC models. Confluent HUVEC cells that display cobblestone monolayer morphology were used for the study of transcellular trafficking on Falcon 3-D cell culture inserts. We studied the effect of caveolin-1 expression on cellular cholesterol transport and efflux. (Abstract shortened by UMI.)