title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°Ð»Ð»Ð¾Ð³ÐµÐ½Ð½ÑÑ ÑÐ¸Ð±ÑÐ¾Ð±Ð»Ð°ÑÑÐ¾Ð² Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¾Ð¶Ð¾Ð³Ð¾Ð²ÑÑ Ð¿Ð¾ÑÐ°Ð¶ÐµÐ½Ð¸Ð¹ III ÑÑÐµÐ¿ÐµÐ½Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Evaluation of the efficiency of the drug based on allogeneic fibroblasts for the treatment of III-degree burns
Creators: name: Ð Ð¾Ð´Ð¸Ð¾Ð½Ð¾Ð²Ð°, ÐÑÐ¸ÑÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¾Ð¶Ð¾Ð³ III ÑÑÐµÐ¿ÐµÐ½Ð¸
ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¹ Ð¿ÑÐ¾Ð´ÑÐºÑ
Ð°Ð»Ð»Ð¾Ð³ÐµÐ½Ð½ÑÐµ ÑÐ¸Ð±ÑÐ¾Ð±Ð»Ð°ÑÑÑ
ÑÐ°Ð½Ð¾Ð·Ð°Ð¶Ð¸Ð²Ð»ÐµÐ½Ð¸Ðµ
Ð³Ð¸ÑÑÐ¾Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸Ñ ÐºÐ¾Ð¶Ð¸
Ð³ÑÐ°Ð½ÑÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐºÐ°Ð½Ñ
III-degree burn
cell product
allogeneic fibroblasts
wound healing
skin histomorphology
granulation tissue

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description: Wound healing is a complex cell process involving various mechanisms and making it critical for designing new approaches of treatment of different skin defects, in particular burns. This work deals with the assessment of the wound-healing ability of biomedical cell product Â«FibrogelÂ» based on allogeneic fibroblasts on the rat model of III-degree burn. There were planimetric significant differences in wound healing rates between the main and control groups of animals. With the use of cytological and histological studies, the quantitative and qualitative indicators of tissue healing were evaluated, respectively. By the 16th day of the experiment, a regenerative type of cytograms was detected in the Â«FibrogelÂ» group, consisting in a significant number of fibroblasts in the wound area (3,5 times more than in the control groups). Moreover, biopsy samples of the main group showed the presence of mature granulation tissue and a large number of vessels of microvasculature by the end of the experiment, which demonstrates the specific wound-healing ability of the studied cell product.