cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of romantic themes in erotica on plethysmographically-assessed sexual arousal in males
Creators: name: Quackenbush, Debra Marie
Publisher: name: University of Utah
Year: 2012

description: The present study was designed as an extension of our earlier work which examined the gender effects associated with self-reports of sexual arousal to romantic themes in sexually explicit videos. In our previous study, we found that both male and female college students reported greater arousal to explicit videos with, than without, expressions of love and affection portrayed in the video. It was proposed that males may have been distorting their reports of sexual arousal in order to appear socially desirable. The present study addressed this concern by (1) utilizing the penile plethysmograph in order to provide a cross-validation of sexual arousal, and (2) including a measure of social desirability in order to determine its relationship to self-reported sexual arousal.  In the current study, 42 male subjects, run individually, viewed a baseline video and one of two experimental videos while wearing a penile strain gauge. One experimental video contained a couple interacting affectionately followed by the same couple engaging in explicit, sexual behaviors (High Love/Affection condition). The other video (Low Love/Affection condition) contained a still photo of the couple followed by sexual content identical to that of the other video. Following the videos, subjects were asked to self-report their sexual arousal as well as complete several demographics and attitudinal measures.  Plethysmographic data suggested that subjects who viewed the High Love/Affection video demonstrated some sexual arousal to the romantic content alone. Subjects who viewed the Low Love/Affection video demonstrated no sexual arousal until the sexual portion of the video commenced. After about 50 seconds of sexual content, group differences in plethysmographically-assessed sexually arousal disappeared. Further, unlike in our previous study, self-reports of sexual arousal did not statistically differ between the two groups.  Attitudes about the role of love and affection in sexual activity were statistically unrelated to both physiologically-assessed and self- reported sexual arousal. The meaning of the data, the differences between the results of our past and present studies, and implications for future research, are discussed.
Polyunsaturated fatty acid-based targeted nanotherapeutics to enhance the therapeutic efficacy of docetaxel
Creators: name: Ramasamy, Thiruganesh
name: Sundaramoorthy, Pasupathi
name: Ruttala, Hima Bindu
name: Choi, Yongjoo
name: Hyun Shin, Woo
name: Jeong, Jee-Heon
name: Ku, Sae Kwang
name: Choi, Han-Gon
name: Kim, Hwan Mook
name: Yong, Chul Soon
name: Kim, Jong Oh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo. They showed high payload carrying capacity with controlled release characteristics and selective endocytic uptake in folate receptor-overexpressing MCF-7 and MDA-MB-231 cells. PUFA synergistically improved the anticancer efficacy of DTX in both tested cancer cell lines by inducing a G2/M phase arrest and cell apoptosis. Combination of PUFA and DTX remarkably downregulated the expression levels of pro-apoptotic and anti-apoptotic markers, and blocked the phosphorylation of AKT signaling pathways. Compared to DTX alone, FA-PLN/DTX showed superior antitumor efficacy, with no signs of toxic effects in cancer xenograft animal models. We propose that PUFA could improve the therapeutic efficacy of anticancer agents in cancer therapy. Further studies are necessary to fully understand these findings and achieve clinical translation.
Sonnenfleckenzeichnung Nr. 23421.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23405.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats
Creators: name: Ibrahim, Shaimaa S.
name: Osman, Rihab
name: Mortada, Nahed D.
name: Geneidy, Ahmed-Shawky
name: Awad, Gehanne A. S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Pulmonary bed can retain microparticles (MP) larger than their capillaries’ diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP for IV use. Lung tolerability and targeting efficiency of Enox-Alb MS were tested, and the pharmacokinetic profile following IV administration to albino rats was constructed. In vivo studies confirmed high lung targeting efficiency of Enox-Alb MS with lack of potential tissue toxicity. The anticoagulant activity of the selected Alb MS was significantly sustained for up to 38 h compared to 5 h for the market product. Alb MS are promising delivery carriers for controlled and targeted delivery of Enox to the lungs for prophylaxis and treatment of pulmonary embolism.
Magnetically ordered non-Prussian blue structured manganese(II) Prussian blue analogues
Creators: name: Kareis, Christopher Michael
Publisher: name: University of Utah
Year: 2013

description: Of the many different classes of molecule-based magnets (MBMs) none are better understood or studied than Prussian blue (PB) and its analogues. Even though this field is centuries old there still remain many interesting aspects about Prussian blue analogues (PBAs) left to be discovered. The work described within details an in depth investigation into magnetically ordered non-Prussian blue structured Mn(II) PBAs. The reaction of the alkali metal cyanides with Mn(II) salts (e.g., Mn(O2CMe)2) formed a material of composition A2Mnn[Mnn(CN)6] (A = K, Rb, Cs) and Na2Mnn[Mnn(CN)6]^2H2O which was dehydrated to form Na2Mnn[Mnn(CN)6]. While the Cs analogue exhibited the typical face centered cubic (fcc) structure expected for Prussian blue structured materials; the K, Rb, and hydrated Na analogues have monoclinic unit cells. Even further reduced from the fcc unit cell is the dehydrated Na analogue which has a hexagonal unit cell. The linearity of the Mn-N^c bonds increases as the size of the alkali metal cation increases [142.4° (Na+) > 148.8° (K+) > 153.3° (Rb+) > 165.3° (Na+^2H2O) > 180° (Cs+)] which directly effects the magnetic ordering temperature, Tc [59 K (Na+) > 41 K (K+) > 34.6 K (Rb+) > 30 K (Na+^2H2O) > 21 K (Cs+)]. Currently, the structure of the material which resulted from the reaction of LiCN^DMF and Mn(O2CMe)2 has not been solved hindering further conclusions about this material. The reaction of tetraethylammonium cyanide and Mn(II) salts yielded a new PBA of [Et4N]2 MnII3 (CN) 8 composition that exhibited an unprecedented layered two-dimensional (2-D) structure with both octahedral and tetrahedral Mn(II) sites. Due to negligible intralayer coupling, [NEt4]2[Mn3(CN)8] orders as a ferrimagnet at 25 K with a coercive field and remnant magnetization of 1140 Oe and 22,800 emuOe/mol, respectively. When the reaction is carried out in methanol a material of [Et4N]Mn''3(CN)7 composition formed in which the 2-D layers, similar to that observed for [Et4N]2Mn''3(CN)8, are bridged through the tetrahedral sites forming an extraordinary threedimensional (3-D) bridged layered structure. [NEt4]Mn3(CN)7 orders as an antiferromagnetic and is the first Prussian blue analogue possessing an antiferromagnetic ground state lacking both a coercive field and remanant magnetization. The reaction of tetramethylammonium cyanide with Mn(O2CMe)2 yielded [NMe4]3Mn5(CN)13 which is the first material to incorporate a pentacyanomanganate ion. Thermal decomposition of either [Et4N]2MnII3(CN)8, [Et4N]MnII3(CN)7, or [NMe4]3Mn5(CN)13 led to the formation of a material of MnII(CN)2 composition which possess an interpenetrating sphalerite-type 3-D framework similar to that of Mn"[Mn"(CN)4].
Sonnenfleckenzeichnung Nr. 23514.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.11.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways
Creators: name: Pi, Jiang
name: Jiang, Jinhuan
name: Cai, Huaihong
name: Yang, Fen
name: Jin, Hua
name: Yang, Peihui
name: Cai, Jiye
name: Chen, Zheng W.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer

description: Selenium nanoparticles (Se NPs) have attracted increasing interest in recent decades because of their anticancer, immunoregulation, and drug carrier functions. In this study, GE11 peptide-conjugated Se NPs (GE11-Se NPs), a nanosystem targeting EGFR over-expressed cancer cells, were synthesized for oridonin delivery to achieve enhanced anticancer efficacy. Oridonin loaded and GE11 peptide conjugated Se NPs (GE11-Ori-Se NPs) were found to show enhanced cellular uptake in cancer cells, which resulted in enhanced cancer inhibition against cancer cells and reduced toxicity against normal cells. After accumulation into the lysosomes of cancer cells and increase of oridonin release under acid condition, GE11-Ori-Se NPs were further transported into cytoplasm after the damage of lysosomal membrane integrity. GE11-Ori-Se NPs were found to induce cancer cell apoptosis by inducting reactive oxygen species (ROS) production, activating mitochondria-dependent pathway, inhibiting EGFR-mediated PI3K/AKT and inhibiting Ras/Raf/MEK/ERK pathways. GE11-Se NPs were also found to show active targeting effects against the tumor tissue in esophageal cancer bearing mice. And in nude mice xenograft model, GE11-Ori-Se NPs significantly inhibited the tumor growth via inhibition of tumor angiogenesis by reducing the angiogenesis-marker CD31 and activation of the immune system by enhancing IL-2 and TNF-α production. The selenium contents in mice were found to accumulate into liver, tumor, and kidney, but showed no significant toxicity against liver and kidney. This cancer-targeted design of Se NPs provides a new strategy for synergistic treating of cancer with higher efficacy and reduced side effects, introducing GE11-Ori-Se NPs as a candidate for further evaluation as a chemotherapeutic agent for EGFR over-expressed esophageal cancers.
Protein kinase C and calcium binding proteins in Balanus photoreceptors
Creators: name: Burnham, Jeffrey Wentworth
Publisher: name: University of Utah
Year: 2012
Subjects: Immunocytochemistry
Phototransduction

description: Phototransduction in visual receptors consists of the conversion of light energy to an intracellular chemical signal which culminates in generation of a receptor potential. The intracellular mechanisms that mediate between these input-output events remain to be clearly elucidated. The purpose of the present investigation was to determine, largely with immunocytochemical techniques, whether certain putative second messengers of visual transduction could be identified and localized in giant Balanus eburneus photoreceptors. Based on previous eletrophysiological experiments, protein kinase C (PKC), phospholipase C (PLC) and certain Ca2+ binding proteins were of particular interest. Several different methods were employed to establish the existence and locale of the putative messengers: 1) light microscopy of thick frozen sections, 2) light and electron microscopy of thin and ultrathin plastic-embedded sections, and 3) SDS polyacrylamide gel electrophorsis and Western blotting of separated cell proteins. These methods were used in conjunction with antibodies to label different isoforms of PKC and the Ca2+ binding proteins Calbindin D28k (Cal D), Calmodulin and Calsequestrin. Results from three different anti-PKC antibodies used on cryosections collectively indicated the presence of PKC in the photoreceptors. SDS polyacrylamide gels of phtoreceptors revealed a positive reaction product when stained with anti-PKC (381-394); the band corresponded to the molecular weight of PKC (80,000). Experimental results from plastic sections proved to be less consistent than experiments with cryosections. Antiserum to Phospholipase C (PLC) showed no positve reaction product in the photoreceptors. A polyclonal antibody to Calbindin D28k proved reactive in cryosections of the photoreceptors. A calcium indicator, Stainsall," prouced several strong bands on protein gels suggesting the present of several Ca2+ binding proteins in the photoreceptor. Antibody reactions to calsequestrin and calmodulin proved negetive. These results provide evidence that one member of the phophoinositide cascade, PKC, is demonstrable in Balanus photoreceptors. It was not possible in these studies to demonstrate any qualitative differences in the amount or locale of this kinase in light an dark adapted specimens. However, the apparent location of PKC in the rhabdomes and PLC in a region adjacent to them is suggestive of a role for them in transduction. The significance of the finding that Cal D resides in the photoreceptors is unknown, but its identity and the tentative identifcation of other Ca2+ binding proteins indicate potential intracellular stores of this important ion.
GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways
Creators: name: Pi, Jiang
name: Jiang, Jinhuan
name: Cai, Huaihong
name: Yang, Fen
name: Jin, Hua
name: Yang, Peihui
name: Cai, Jiye
name: W. Chen, Zheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer

description: Selenium nanoparticles (Se NPs) have attracted increasing interest in recent decades because of their anticancer, immunoregulation, and drug carrier functions. In this study, GE11 peptide-conjugated Se NPs (GE11-Se NPs), a nanosystem targeting EGFR over-expressed cancer cells, were synthesized for oridonin delivery to achieve enhanced anticancer efficacy. Oridonin loaded and GE11 peptide conjugated Se NPs (GE11-Ori-Se NPs) were found to show enhanced cellular uptake in cancer cells, which resulted in enhanced cancer inhibition against cancer cells and reduced toxicity against normal cells. After accumulation into the lysosomes of cancer cells and increase of oridonin release under acid condition, GE11-Ori-Se NPs were further transported into cytoplasm after the damage of lysosomal membrane integrity. GE11-Ori-Se NPs were found to induce cancer cell apoptosis by inducting reactive oxygen species (ROS) production, activating mitochondria-dependent pathway, inhibiting EGFR-mediated PI3K/AKT and inhibiting Ras/Raf/MEK/ERK pathways. GE11-Se NPs were also found to show active targeting effects against the tumor tissue in esophageal cancer bearing mice. And in nude mice xenograft model, GE11-Ori-Se NPs significantly inhibited the tumor growth via inhibition of tumor angiogenesis by reducing the angiogenesis-marker CD31 and activation of the immune system by enhancing IL-2 and TNF-α production. The selenium contents in mice were found to accumulate into liver, tumor, and kidney, but showed no significant toxicity against liver and kidney. This cancer-targeted design of Se NPs provides a new strategy for synergistic treating of cancer with higher efficacy and reduced side effects, introducing GE11-Ori-Se NPs as a candidate for further evaluation as a chemotherapeutic agent for EGFR over-expressed esophageal cancers.
El corazon de la cebolla: a mini-ethnographic study of Mexicana/o symptom interpretation and management
Creators: name: French, Melody Weaver
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Utah
subject: Demography
subject: FOS: Sociology
subject: Health Servies

description: The purpose of this urban mini-ethnographic qualitative study was to examine Mexicana/o symptom interpretation and management utilizing the Common Sense Model of Illness Representation as a guiding framework. Latina/os are a growing part of the population in the United States and are estimated to comprise 25% of the total population by the year 2050. The Latina/o population is diverse. Mexicana/os represent 68% of the Latina/o population in Utah. Despite growing numbers of Latina/os living within the borders of the United States, little work has been conducted that addresses the healthcare needs of this population. Research to date has focused on issues of health status, utilization of health promotion and disease prevention services, barriers to healthcare, and explication of culture-based syndromes. In addition, little work has been performed to assess the interpretation and management of common symptoms. Multiple methods of data collection were used, including meetings with key informants, interviews with participants, participant observations, photography, literature, documents, and artifacts. Immersion into the data and the development of a coding scheme were the initial steps in data analysis. Data management was accomplished with the assistance of QSR NUD*IST4©. The Common Sense Model guided the research process. Participants told complex stories of symptom interpretation, with cost of healthcare emerging as the overall theme affecting decisions regarding management of the symptoms they selected. Although I initially believed that culture would play a much larger role in how the participants addressed their symptoms, cost was an even greater issue. Poverty may be a factor affecting healthcare and access to healthcare that is even more important than culture. Further inquiry is warranted. However, clinical practice will be enhanced through an understanding of the illness representation and decision-making processes of the participants. Culture is an important factor affecting specific ways in which participants address a particular symptom. What may be considered by clinicians to be noncompliant behavior may be implementation of self-care modalities prior to entering the conventional healthcare system or following ineffective treatment by the conventional healthcare system-decisions influenced by the cost of healthcare services.
Nanoemulsion-based delivery system for enhanced oral bioavailability and caco-2 cell monolayers permeability of berberine hydrochloride
Creators: name: Li, Yong-Jiang
name: Hu, Xiong-Bin
name: Lu, Xiu-Ling
name: Liao, De-Hua
name: Tang, Tian-Tian
name: Wu, Jun-Yong
name: Xiang, Da-Xiong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Berberine hydrochloride (BBH) has a variety of pharmacological activities such as antitumor, antimicrobial, anti-inflammation, and reduce irritable bowel syndrome. However, poor stability and low oral bioavailability limited its usage. Herein, an oil-in-water nanoemulsion system of BBH was developed to improve its stability and oral bioavailability. The pseudoternary phase diagrams were constructed for the determination of composition of various nanoemulsions. The nanoemulsions of BBH composed of Labrafil M 1944 CS (oil phase), RH-40 (surfactant), glycerin (co-surfactant), and water (aqueous phase). The O/W nanoemulsion of BBH showed a relative bioavailability of 440.40% compared with unencapsulated BBH and was stable in our 6-month stability study. Further, there was a significant increase in intestinal permeability of BBH as assessed by Caco-2 cell monolayers and a significant reduction in efflux of BBH by the multidrug efflux pump P-glycoprotein. This study confirmed that the nanoemulsion formulation could be used as an alternative oral formulation of BBH to improve its stability, oral bioavailability and permeability.
Electrical impedance of human urine
Creators: name: Roberts, Deanne Davis
Publisher: name: University of Utah
Year: 2012
Subjects: Impedance, Bioelectric

description: Electrical impedance measurements were taken on 269 samples of human urine to compare the mean impedance of abnormal urine to the mean impedance of normal urine. Samples obtained from the population of specimens sent to The University of Utah Clinical Chemistry Lab were assigned to seven different categories based on their urinalysis results. The methodology controlled for the following variables:  (1) solution volume; (2) type, size and distance between electrodes; (3) frequency and amperage of the input current; and, (4) temperature of the solution. Impedance measurements were taken using a High Resolution Impedance Convertor (Transmed Scientific Model 2991), which provided 50 uA constant current at 50 kHz.  The results of this study indicate that:  (1) There is no significant difference in mean impedance between normal urine and urine containing higher than normal amounts of either red blood cells, white blood cells, protein, glucose, bacteria, or Pyridium; and, (2) there is a significant difference between the mean impedance of normal urine and urine that is either concentrated (specific gravity ? 1.025) or dilute (specific gravity ? 1.003).  It was also found that impedance readings varied considerably within each category. These findings suggest that factors other than those identified for this study may significantly influence the electrical impedance of human urine.
Sonnenfleckenzeichnung Nr. 23448.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Investigation of the primary stimulus and mechanism of the ammonium chloride-induced increase in the content of potassium in choroid plexus epithelial cells
Creators: name: Harbut, Ronald Eugene Daniel
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism
Potassium

description: After young adult male rate were injected intraperitoneally with NH4C1, the content of K (hereafter, CP [K]) within the epithelial cells of the choroid plexus increased greatly while that of  Na (CP [K]) decreased.  This dissertation has focused on elucidating the primary stimulus and mechanism of the NH4C1-induced increase in CP [K], with some investigative focus on the induced decrease in CP [Na].  The primary stimuli under consideration are the NH4C1-induced increases in plasma [NH4], [K]. and [H], and decreases in [HCO3] and [Na].  An acidosis-induced augmentation in the concentration of catecholamines available to CP beta-adrenoceptors has also been considered.  Since sympathectomy, adrenalectomy or pretreatment with beta-adrenoceptor blockers did not reduce the effects of NH4C1, it was possible to rule out an involvement of catecholamines as the stimulus.  A comparison of the time-courses of plasma [ammonia] with CP [K] and [Na} indicated that the primary stimulus was not plasma [NH4].  A comparison of the effects of nine individual salt treatments on plasma [K] with CP [K] and [Na}, revealed that plasma [K] was not the primary stimulus.  Significant statistical correlations were drawn between plasma [H] and the induce increase in CP [K] and decrease in CP [Na].  Since an elevation of plasma [H] was most consistently associated with and increase in CP [K], the mechanism through which [H] operates was investigated. The increase in CP [K] and decrease in CP [Na] must result from wither an increase in Na-k exchange (Na-K Atpase), or from a decrease in K efflux and Na influx; or perhaps a combination of both.  With a physiological analog of K (i.e., Rb), it was demonstrated that acidosis does not increase the slope of the initial ‘linear uptake of 86Rb in vitro; thus no effect of acidosis to increase Na-Rb exchange (i.e., Na-K exchange) was found.  Since acidosis augments the steady-state volume of distribution of 86Rb in vitro, without an increase in Na-Rb exchange, it would appear that acidosis augments CP Rb by effecting a reduction in Rb efflux and, by analogy, would also reduce the efflux of CP K.  In conclusion, NH4C1 induces an increase in CP [K] by increasing plasma [H] which in turn acts to reduce the efflux of K across the apical and/or basolateral membranes of the CP.  An in vivo indication that acidosis reduces the efflux of K across the apical membrane was suggested by a decrease in CSF [K].
Satellite and ground based observations of lightning flashes in the stratiform and anvil regions of convective systems
Creators: name: Peterson, Michael Jay
Publisher: name: University of Utah
Year: 2012
Subjects: Anvil region
Lightning
LIS
Stratiform region
TRMM
TWP-ICE
Convective systems
Convective clouds

description: Flashes in the anvil and stratiform regions of storms are identified and their statistics are analyzed from Tropical Rainfall Measuring Mission (TRMM) observations  between 1998 and 2009. In total, ~5% of all lightning flashes are observed in either the anvil or stratiform region. Global distributions and seasonal and diurnal variations of these flashes are discussed. Electric Charging Regions (ECRs) are identified by grouping  areas with 30 dBZ radar echo at 6 km from TRMM Precipitation Radar (PR) observations. Then, flashes in the anvil and stratiform regions are associated to their  nearest ECRs. About ~15% of all ECRs near lightning have been found to be associated with at least one stratiform or anvil lightning flash. The relationships between these flashes and their nearest ECRs are discussed.  To validate the results from TRMM observations, ground-based observations from the Tropical Warm Pool International Cloud Experiment (TWP-ICE) are analyzed.  Based on the results of both data sets, flashes in the anvil region are found to often occur near the edges of convective cells within single cell systems, and many of them occur in relatively early stages of convection. Stratiform flashes, on the other hand, are more  common as convective systems weaken, and many of them occur within multicellular systems.
KESS: Knowledge Engineering Support System
Creators: name: Ben Said, Mohamed
Publisher: name: University of Utah
Year: 2012
Subjects: Artificial Intelligence
Medical Informatics Applications
Expert Systems
Decision Making, Computer-Assisted

description: Building an expert system in medicine is a difficult, time-consuming job.  It involves many meetings of people from various disciplines.  In each of the sessions, statements about the relationships used in decision-making are made by experts, data are examined from medical literature and hypothetical relationships are tested against local patient data bases.  In order to maintain continuity and provide future reference to this process, a relational information management system know as Knowledge Engineering Support System or KESS was created at the University of Utah.  KESS utilizes many-to-many links with multiple files and central link files to track the different kinds of information generated and used in the four knowledge building projects.  It is used on-line during the expert meetings or knowledge engineering sessions to enter new data or to revise and update information already entered in previous sessions.  The data can be retrieved using indexed fields or by using macros to generate reports.  The reports can be printed or sent via modem to the expert at his or her workstation.  KESS uses a commercial software that has the advantage of being immediately available, thereby avoiding the design of a database management systems from scratch.  It also has the advantage of allowing easy and safe data transfer between different version of KESS program.  The condition of the development and the use of KESS will be described in more detail in the thesis.
Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats
Creators: name: Ibrahim, Shaimaa S.
name: Osman, Rihab
name: Mortada, Nahed D.
name: Geneidy, Ahmed-Shawky
name: A. S. Awad, Gehanne
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Pulmonary bed can retain microparticles (MP) larger than their capillaries’ diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP for IV use. Lung tolerability and targeting efficiency of Enox-Alb MS were tested, and the pharmacokinetic profile following IV administration to albino rats was constructed. In vivo studies confirmed high lung targeting efficiency of Enox-Alb MS with lack of potential tissue toxicity. The anticoagulant activity of the selected Alb MS was significantly sustained for up to 38 h compared to 5 h for the market product. Alb MS are promising delivery carriers for controlled and targeted delivery of Enox to the lungs for prophylaxis and treatment of pulmonary embolism.
Descriptive study of electronic fetal monitoring in a rural community: does it make a difference?
Creators: name: Edwards, Ronald Jonathan
Publisher: name: University of Utah
Year: 2012
Subjects: Tooele Valley Hospital
Utah
Electrical Fetal Monitoring

description: Electronic fetal monitoring (EFM) has become a standard of care in many labor and delivery settings.  Studies of the effects of such monitoring have been inconclusive, although among high-risk women there have been some impressive results attributed to EFM.  The present study investigated the effects of introducing EFM in a rural hospital labor and delivery setting.  Using a retrospective cohort design, charts of 749 obstetrical cases admitted to the Tooele valley Hospital were reviewed and abstracted.  These cases covered a four-year period:  two year before EFM was installed and two years after.  No significant differences (p
Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human
Creators: name: Morsi, Nadia M.
name: Abdelbary, Ghada A.
name: Elshafeey, Ahmed H.
name: Ahmed, M. Abdallah
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosphatidylinositol enriched soybean lecithin to form MSP-phospholipid complex (MSP-PLCP). Changes in physicochemical properties were assessed and the optimum MSP-PLCP formula was then used for formulation into a flushing resistant platform using two mucoadhesive polymers; sodium alginates and sodium carboxymethylcellulose at different concentrations. Design of experiment approach was used to characterize and optimize the formulated flushing resistant platform. The optimized formulation was then used in a comparative pharmacokinetics study with the market formulation in human volunteers. Results showed a marked change in MSP physicochemical properties of MSP-PLCP compared to MSP. Addition of mucoadhesive polymers to flushing resistant platform at an optimum concentration balanced between desired mucoadhesive properties and a reasonable drug release rate. The optimized formulation showed significantly a superior bioavailability in humans when compared to the market sublingual product. Finally, the novel developed sublingual flushing resistant platform offers a very promising and efficient tool to extend the use of sublingual route and widen its applications.
Sonnenfleckenzeichnung Nr. 23494.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Surrogate theory for Hertzian contact pairs: application to simplify wear testing of ceramic hip prosthesis materials
Creators: name: Sanders, Anthony Paul
Publisher: name: University of Utah
Year: 2012
Subjects: Ceramic
Edge loading
Hip
Prosthesis
Squeaking
Wear

description: This dissertation presents a series of research projects aimed at uncovering the causes of severe wear in ceramic-on-ceramic (CoC) hip prostheses and at devising novel contact and wear test methods that accurately replicate its root cause mechanics. CoC prostheses can provide lower wear rates than other types of prostheses; however, their clinical adoption has been inhibited by reports that they are liable to squeak annoyingly. Prior authors have theorized that acetabular edge loading is a precursor to squeaking. In this dissertation, one project has demonstrated the suitability of Hertzian contact theory for predicting the contact mechanics of edge-loaded CoC implants. Another project has shown that a small manufacturing artifact on the edge of ceramic acetabular liners exacerbates edge-loading wear. A third project has discovered the key to reproducing lubricated, recurrent CoC squeaking in vitro using a novel testing approach. The culminating project has engineered a novel approach to averting the CoC squeaking problem. This project has designed and validated a new wear test method to efficiently evaluate ceramic materials' edge-loading wear performance. The new method uses simply shaped surrogate test specimens to substitute for full-scale ceramic hip implants, with the surrogates designed to accurately replicate the severe edge-loading contact stresses of the implants. Three series of wear tests were performed, one using the new approach with surrogate specimens, and the other two using a more direct but complicated approach with edge-loaded full-scale implants; each series included three different ceramic material pairs. The first key outcome was that the surrogate test series yielded the same wear factor ranking as the two series performed using the more complicated method. The second key outcome was that the materials exhibited similar temporal trends in the measured friction force, which implies that the materials became damaged and fragmented by essentially the same mechanisms. These congruent results, comparing surrogate and full-scale test methods, demonstrate that the project has achieved its overarching objective of developing a simple, surrogate specimen wear test that will facilitate screening a larger pool of candidate new materials, at early stages in their development, for their wear performance under severe edge-loading contact stresses.
Effect of pets on spousal bereavement over a two-year period
Creators: name: Bernstein, Vicki Ellen
Publisher: name: University of Utah
Year: 2012
Subjects: Pets
Loneliness

description: The purpose of this thesis was to examine the effect of pet ownership on bereavement outcomes over a 2-year period. One hundred ninety-two individuals, age 50 to 93 years old, were divided into categories and type of pet ownership and were interviewed six times during 2 years of bereavement. Questionnaires were completed that measured bereavement outcomes (perceived stress, perceived coping, depression, and loneliness). Respondent-generated responses to pet helpfulness also were measured. Findings indicate that pet ownership does not seem to affect bereavement outcomes over time. Loneliness was the response given most frequently in all pet categories to the question: 'What has been the single greatest problem for you related to the death of your spouse?' When compared to mixed species' owners, dog owners had significantly higher stress levels at Time 1. Compared to cat owners, dog owners were significantly more depressed than cat owners at Time 5. Dog owners had decreased depression levels over time. Cat owners had higher perceived coping ability over the last 6 months of bereavement. A majority of pet owners reported that their pets helped them through the bereavement process because of the companionship they provided and, in some cases, a greater sense of protection. The findings of this study suggest that the role of pet ownership in bereavement is complex. Extensive research that examines pet ownership over the life course is needed to understand this phenomenon.
Sonnenfleckenzeichnung Nr. 23372.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Implementierung eines prädiktiven Biomarkers in den diagnostischen Routinealltag am Beispiel der Anaplastischen Lymphom Kinase (ALK) im nicht-kleinzelligen Lungenkarzinom (NSCLC)
Creators: name: Laffert, Maximilian Von
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: nicht-kleinzelliges Lungenkarzinom (NSCLC)
subject: Anaplastische Lymphom Kinase (ALK)
subject: Fluoreszenz in-situ Hybridisierung (FISH)
subject: Immunhistologie (IHC)
subject: anaplastic lymphoma kinase
subject: non-small cell lung cancer
subject: fluorescence in situ hybridization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Im aktuellen Zeitalter der zielgerichteten Krebstherapien müssen sich pathologische Institute in regelmäßigen Abständen auf immer wieder neu zu testende prädiktive Biomarker einstellen. Das bedeutet, dass potentielle Testverfahren validiert werden müssen, sowie der Nachweis der entsprechenden diagnostischen Güte im Rahmen von Ringversuchen gezeigt werden muss. Je seltener das zu testende Ereignis bei der entsprechenden Erkrankung vorkommt, umso schwieriger wird die Gesamtsituation. Dies erfordert institutsübergreifende Kooperationen. In der vorliegenden Arbeit konnten wir den Stellenwert der Ringversuche am Beispiel der ALK-Alterationen im NSCLC herausarbeiten. Wir konnten zeigen, dass der diagnostische Goldstandard (FISH) unter gewissen Umständen kritisch betrachtet werden muss. Hinsichtlich der in den Ringversuchen eingesetzten ISH-Verfahren (FISH und CISH), sowie bezüglich der verschiedenen Sonden unterschiedlicher Anbieter zeigten sich keine Vor- oder Nachteile. Die Daten zeigen weiterhin, dass nur bestimmte Antikörper-Klone nach Harmonisierung der Methodik im immunhistologisch diagnostischen Alltag verlässlich eingesetzt werden können. Dieser Ansatz ist nicht nur zeit- und kostensparend, sondern verbessert zusätzlich die diagnostische Sicherheit insbesondere bei den „Borderline“-Fällen. Bisherige und zukünftig NGS-basierte Daten werden dabei helfen, die IHC nicht nur als Screening-Methode, sondern gegebenenfalls als „stand-alone“ Test zu etablieren. Dennoch, in immunhistologisch unklaren Fällen sollte mindestens eine weitere Methode (ISH, NGS) angewendet werden können. Hierbei ist das Wissen um deren Vor- und Nachteile und der damit verbundenen Ergebnisinterpretation entscheidend. In der Folge wird die FISH, welche die Methode der Wahl in den zur Medikamentenzulassung führenden Studien war, möglicherweise an ihrer zentralen Bedeutung verlieren. Begründet ist dies nicht nur in etwaigen technischen Artefakten, auch wirtschaftliche Argumente (Kosten, technischer und zeitlicher Aufwand, Bearbeitungszeit) spielen letztendlich eine Rolle. Ein Screening aller Lungenkrebsfälle mittels FISH ist nicht in jeder Institution umzusetzen, mittels IHC ist dies leichter möglich. Ferner erlauben es die zur Verfügung stehenden NGS-Panel neben ALK weitere Marker wie z.B. ROS1 parallel mit zu testen, um eine qualifizierte Entscheidung für eine optimale Therapie zu ermöglichen.
Brief an [Gottfried] Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1683

description: von Joh[ann] Wölffing
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog