cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thick and Thin: The Future for Walls as Solid Masses or Delicate Layers
Creators: name: Marriage, Guy
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2021
Subjects: subject: 120199 Architecture not elsewhere classified
subject: FOS: Civil engineering
subject: 120101 Architectural Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120202 Building Science and Techniques

description: While houses built from engineered timber products such as cross‐laminated timber are an excellent structural construction solution, the mass house construction market in New Zealand still sticks with more traditional construction methods centred on individual sticks of timber. These traditional methods are however still reliant on timber sizes that are relatively weighty and volumetrically large, in relation to more advanced cladding systems such as cars or planes, where thin skins of cladding are carefully wrapped over a lightweight but structurally rigorous framework. This paper examines current and future walls, including possible structural solutions such as the stressed skin matrix and monocoque construction methods that are widely used in vehicles. Comparisons are made with other technologies where recent advances in large‐scale 3D printing have created entire houses fabricated from liquidised amorphous substances. Can they be reliably considered as practical building systems for the future? Recent advances in 3D printing are multiplying, including the ability to sinter solids directly from sand, being explored as a possible future for building “off‐shore” constructions. The paper draws upon advances being worked in freeform 3D printing and real‐life building projects as well as examining the future of student‐led research into digitally‐led building construction systems.
A BVD Wreck
Creators: name: Stout, Robert G.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: In December of 1982 a client of ours purchased 254 head of 530 pound steer calves at a local auction market, "processed" the cattle according to our recommendations and placed the cattle in their own feedlot. Within 6 days the cattle started getting sick. Despite individual and herd treatment, calves started dying-12 head within the next 4 days. A diagnosis of Bovine Virus Diarrhea (BYD) with secondary bronchopneumonia was made. This paper describes "the wreck," the experiences and prejudices of the veterinarians prior to this event, their effort to establish the pathogenesis and epidemiology involved, and finally-what effect this wreck had on their recommendations for disease prevention in a feedlot practice.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Bovine Surgery
Creators: name: Hull, Bruce L.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: Bloat in feedlot cattle often fails to respond to medical therapy. Constant tubing of the bloated animal often leads to esophageal irritation which in itself may perpetuate the bloat condition. The chronic bloat animal is often a poor doer, either because of the underlying cause of the bloat, or because of the bloat itself which interferes with feed consumption. Also one must consider the economics of constant treatment and the possibility of sudden death. Considering these things one should consider surgical methods of bloat relief in any case of bloat which fails to respond to 1-2 days of medical therapy. Often these are feedlot cattle which have recently been started on a high grain ration.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Clinical Considerations of Bovine Coccidiosis
Creators: name: Eness, Paul G.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: As bovine practitioners we probably have a poorer understanding of the protozoan diseases than of diseases of bacterial or viral etiology. This, despite the fact that coccidiosis, the most common of the protozoan diseases, is one of the major diseases of feedlot cattle. One survey indicated that coccidiosis costs an average of $54.25 per infected animal. In addition to the economic losses associated with weight loss, treatment cost and death of the acutely involved animal there are significant, more subtle costs associated with the oft unrecognized subclinical form of the disease. This paper will address both forms of the disease.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Resistance to BRAF inhibitors : EZH2 and its downstream targets as potential therapeutic options in melanoma
Creators: name: Uebel, Anne
name: Kewitz-Hempel, Stefanie
name: Willscher, Edith
name: Gebhardt, Kathleen
name: Sunderkötter, Cord
name: Gerloff, Dennis
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Activating BRAF mutations occurs in 50–60% of malignant melanomas. Although initially treatable, the development of resistance to BRAF-targeted therapies (BRAFi) is a major challenge and limits their efficacy. We have previously shown that the BRAFV600E signaling pathway mediates the expression of EZH2, an epigenetic regulator related to melanoma progression and worse overall survival. Therefore, we wondered whether inhibition of EZH2 would be a way to overcome resistance to vemurafenib. We found that the addition of an EZH2 inhibitor to vemurafenib improved the response of melanoma cells resistant to BRAFi with regard to decreased viability, cell-cycle arrest and increased apoptosis. By next-generation sequencing, we revealed that the combined inhibition of BRAF and EZH2 dramatically suppresses pathways of mitosis and cell cycle. This effect was linked to the downregulation of Polo-kinase 1 (PLK1), a key regulator of cell cycle and proliferation. Subsequently, when we inhibited PLK1, we found decreased cell viability of melanoma cells resistant to BRAFi. When we inhibited both BRAF and PLK1, we achieved an improved response of BRAFi-resistant melanoma cells, which was comparable to the combined inhibition of BRAF and EZH2. These results thus reveal that targeting EZH2 or its downstream targets, such as PLK1, in combination with BRAF inhibitors are potential novel therapeutic options in melanomas with BRAF mutations.
Proteins adsorbed during intraoperative hemoadsorption and their in vitro effects on endothelium
Creators: name: Piskovatska, Veronika
name: Navarrete Santos, Alexander
name: Kalies, Katrin Veronika Dorothea
name: Korca, Edina
name: Stiller, Markus
name: Szabó, Gábor
name: Simm, Andreas
name: Wachter, Kristina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: (1) Background: Hemoadsorption is a method of blood purification with a wide spectrum of indications. Pre-emptive use of hemoadsorption in patients undergoing heart surgery with cardiopulmonary bypass is considered to reduce the risk of postoperative systemic inflammatory response syndrome. The current study aimed to identify the spectrum of blood proteins adsorbed on the polymer matrix of the CytoSorb hemoadsorption system and to investigate their influence on cultured endothelial cells in vitro. (2) Methods: Adsorbers used for intraoperative hemoadsorption were obtained from patients undergoing on-pump valve surgery in acute endocarditis. Proteins were extracted from the adsorbers, purified, identified with mass-spectrometry and applied to cultured human aortic endothelial cells. (3) Results: A broad range of blood proteins were identified in the material eluted from the CytoSorb adsorber. When added to cultured ECs, these protein extracts caused severe reduction in cell viability and migration. After 24 h exposure, transcriptional changes with up-regulation of multiple metabolic regulators were observed and verified on the protein level. Genes responsible for control of mitosis were significantly down-regulated. (4) Conclusions: In summary, our data reveal that intraoperative hemoadsorption allows broad spectrum removal of a wide range of molecules eliciting endothelial damage.
DESIGN, COMMUNICATION & COLLABORATION IN IMMERSIVE VIRTUAL ENVIRONMENTS
Creators: name: SCHNABEL, MAKVAN
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2021
Subjects: Uncategorized

description: Virtual Environments (VE) are increasingly offered as environments for design. Using VE to visualize ideas from the initial steps of design, the architect is challenged to deal with perception of space, solid and void, without translations to and from a two dimensional media. From this new ability, we might expect new forms of design expression. The goal of our study was to identify how designers use and communicate early design ideas by using immersive three-dimensional VEs. We set-up a series of experiments including navigation- and perception-tasks, designing in immersive VE, transcription of design, remote communication between design partners and controlled observations. We explored initial intentions of three-dimensional (3D) immersive design schemes, textual descriptions and collaborations within immersive VE. This article describes the outcome of creation, interpretation and communication of architectural design, by using a 3D maze together with text-based communication in a series of collaborative design experiments. We conducted the first successful attempt of a Joint Design Studio, which uses immersive VE as tool of design and communication between remote partners. We discuss frameworks and factors influencing how architectural students communicate their proposals in an immersive Virtual Environment Design Studio (VeDS), and how this new approach of design studio enables new forms of design expressions.
Small structural differences govern the carbonic anhydrase II inhibition activity of cytotoxic triterpene acetazolamide conjugates
Creators: name: Denner, Toni C.
name: Heise, Niels
name: Zacharias, Julian
name: Kraft, Oliver
name: Hoenke, Sophie
name: Csuk, René
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Acetylated triterpenoids betulin, oleanolic acid, ursolic acid, and glycyrrhetinic acid were converted into their succinyl-spacered acetazolamide conjugates. These conjugates were screened for their inhibitory activity onto carbonic anhydrase II and their cytotoxicity employing several human tumor cell lines and non-malignant fibroblasts. As a result, the best inhibitors were derived from betulin and glycyrrhetinic acid while those derived from ursolic or oleanolic acid were significantly weaker inhibitors but also of diminished cytotoxicity. A betulin-derived conjugate held a Ki = 0.129 μM and an EC50 = 8.5 μM for human A375 melanoma cells.
“Totally Under Control”: Maintaining Stability and Managing Outbreaks of Infectious Diseases in China
Creators: name: Zhang, Jichun
Publisher: name: University of Chicago
Year: 2021
Subjects: subject: stability maintenance

description: This paper examines how China’s stability maintenance regime responded to the COVID-19 pandemic. I show how party organs in hospitals or neighborhoods worked collaboratively with the police force but shifted shared goals of keeping outsiders uninformed of the outbreak to that of controlling the society and assisting efforts of the state to contain the pandemic once the central government formally recognized the outbreak and decided to take drastic measures. Married existing theories of stability maintenance to crisis management, I argue that stability maintenance institutions undermined the autonomy of frontline health workers and therefore made not only the public but central government inaccessible to key information at the early warning stage, but they appeared to be conducive to disease control and greatly enhanced state’s mobilizational capacity at the stage of comprehensive engagement.
Towards the 4th post-Newtonian Hamiltonian for two-point-mass systems
Creators: name: Jaranowski, Piotr
name: Schäfer, Gerhard
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The article presents the conservative dynamics of gravitationally interacting two-point-mass systems up to the eight order in the inverse power of the velocity of light, i.e.\ 4th post-Newtonian (4PN) order, and up to quadratic order in Newton's gravitational constant. Additionally, all logarithmic terms at the 4PN order are given as well as terms describing the test-mass limit. With the aid of the Poincaré algebra additional terms are obtained. The dynamics is presented in form of an autonomous Hamiltonian derived within the formalism of Arnowitt, Deser and Misner. Out of the 57 different terms of the 4PN Hamiltonian in the center-of-mass frame, the coefficients of 45 of them are derived. Reduction of the obtained results to circular orbits is performed resulting in the 4PN-accurate formula for energy expressed in terms of angular frequency in which two coefficients are obtained for the first time.
description: ReVTeX 4-1, 4 pages
Fescue Toxicity Syndrome
Creators: name: Miksch, Duane
name: Lacefield, Garry
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: Tall fescue is the predominant cool-season grass in a large section of the United States bounded approximately by a line south from Topeka, KS to Tyler, TX, east to Macon, GA, northeast to Philadelphia and west to Topeka. Most of the estimated 35 million acres of tall fescue in that area is the Kentucky 31 (KY 31) cultivar. It is a persistent grass, adapted to a wide range of soil and climatic conditions. Tall fescue is a near perfect plant for soil conservation. It yields a lot of forage and responds well to nitrogen application. The chemical composition compares favorably to orchardgrass, timothy and bromegrass.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
When the Proud Boys Went to the Capitol: Presentation of Self and Other in the American Alt-Light
Creators: name: Icliyurek, Teo
Publisher: name: University of Chicago
Year: 2021
Subjects: subject: Democracy
subject: Far-right
subject: Alt-Light
subject: Proud Boys
subject: Extremism
subject: Political Sociology
subject: Culture
subject: Dramaturgical Analysis
subject: Capitol Insurrection
subject: Donald Trump

description: The Capitol Insurrection, widely condemned as anti-democratic, was an attempt to “stop the steal” of what was claimed to be a fraudulent election. It was composed not of white supremacists and traditional neo-Nazi groups but of a miscellany of actors and groups supporting Donald Trump. This article centers the founder of one of these groups, Gavin McInnes of the Proud Boys, to define a new, discrete subculture in the contemporary American right: the Alt-Light. The term seeks distance from traditional right-wing extremisms, such as white nationalisms, the Klan, and neo-Nazi organizations, revolving instead around western “culture.” This article takes a dramaturgical approach to study lawsuits and videocasts by McInnes, centering transgression and style to think about the Alt-Light as a 21st century, American performance, bounded by white supremacy on one side and “establishment” conservatism on the other.
Residue Avoidance or Veterinary Entrapment
Creators: name: Griffin, Dee
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: It details the quality assurance program covering drug and chemical residues in beef carcasses from The feedlot of Hitch Enterprises. The objecive is to ensure that all beef carcasses from the feedlots of Hitch Enterprises are within established tolerances set by FDA and EPA for pesticides, drugs, and other chemicals. This program will be operated by Hitch Enterprises and will be monitored by USDA through evaluation and review of data as well as by periodic sampling of carcasses at packing plants by FSIS.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Stephanocyathus (Stephanocyathus) platypus SA Tas Vic NSW
Creators: name: Cairns, S. D.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Caryophylliidae
Stephanocyathus
Stephanocyathus platypus

description: Stephanocyathus (S.) platypus (Moseley, 1876) Ceratotrochus platypus Moseley, 1876: 554 (NSW). Stephanocyathus platypus.– Moseley, 1881: 154, pl. 3, figs. 4a,b (description).– Cairns, 1982: 24–25, pl. 7, figs. 3–6 (description, synonymy, NZ).– Veron, 1986: 607 (listed).– Cairns & Parker, 1992: 24–25, figs. 7a–c (SA, Vic, Tas).– Cairns, 1995: 66–67, pl. 17a–c (NZ). New records. NEW SOUTH WALES: Kapala 75/05/05, 1, AM G16560; Kapala 78/27/05, 7, AM G15811; Kapala 78/27/13, 1, AM G16323; Kapala 79/20/13, 2, AM G15238; Kapala 84/08/05, 5, AM G16474. Types. Two syntypes are BM 1880.11.25.57. Type Locality: 34°13'S 151°38'E (off Sydney, New South Wales), 750 m.
description: Published as part of Cairns, S. D., 2004, The Azooxanthellate Scleractinia (Coelenterata: Anthozoa) of Australia, pp. 259-329 in Records of the Australian Museum 56 on page 286
description: {"references": ["Moseley, H. N., 1876. Preliminary report to Professor Wyville Thomson \u2026 on the true corals dredged by the H. M. S. \" Challenger \" in deep water between the dates Dec. 30 th, 1870 and August 31 st, 1875. Proceedings of the Royal Society of London 24: 544 - 569.", "Moseley, H. N., 1881. Report on certain hydroid, alcyonarian, and madreporarian corals procured during the voyage of H. M. S. Challenger, in the years 1873 - 1876. Report on the Scientific Results of the Voyage of H. M. S. Challenger during the Years 1873 - 76, Zoology 2: 248 pp., 32 pls. in three series, 17 figs.", "Cairns, S. D., 1982. Antarctic and Subantarctic Scleractinia. Antarctic Research Series 3 (1): 74 pp., 18 pls., 14 maps.", "Veron, J. E. N., 1986. Corals of Australia and the Indo-Pacific. Pp. xii + 644, many unnumbered figs. North Ryde [Sydney]: Angus & Robertson.", "Cairns, S. D., 1995. The marine fauna of New Zealand: Scleractinia (Cnidaria: Anthozoa). New Zealand Oceanographic Institute Memoir 103: 210 pp., 44 pls., 22 maps."]}
Spaying Flank Method
Creators: name: McElroy, William
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: There are many factors to be considered when determining the economics of spaying heifers. Some of these that might be considered are: I. Cost of spaying 2. Market value of spayed and non spayed heifers 3. Gaining ability of each 4. Maintaining open heifers 5. Cost of heat suppressing drugs 6. Pregnancy problems a. Cost of examination b. Cost of aborting c. Weight loss at aborting d. Pregnancy at slaughter
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Heifer Spaying
Creators: name: Bohlender, Bob
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: But spaying has been a common procedure in the western states for years. It started in Wyoming and it was a management program. When controlled weight studies were conducted, spayed nonimplanted heifers failed to gain up with the intact nonimplanted. Rupp and Kimberly, in reviewing a lot of the trials, reporting 22 of 27 in the early trials intact heifers average daily gain didn't keep up. Intacts had higher AGs than the spayed mates. Including grazing growing and finishing trials, the intact averaged 7.9% higher and this just follows the experience I was having at that time. Then in 15 trials comparing implanted spays and implanted intacts 13 of 15 showed better gain, average of 1.8 improvement, meant that they picked up the 7.9 plus the 1.8 gain. So implanted reporting to have quite a profound effect on the spayed.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Consistent LDA'+DMFT approach to electronic structure of transition metal oxides: charge transfer insulators and correlated metals
Creators: name: Nekrasov, I. A.
name: Pavlov, N. S.
name: Sadovskii, M. V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We discuss the recently proposed LDA'+DMFT approach providing consistent parameter free treatment of the so called double counting problem arising within the LDA+DMFT hybrid computational method for realistic strongly correlated materials. In this approach the local exchange-correlation portion of electron-electron interaction is excluded from self consistent LDA calculations for strongly correlated electronic shells, e.g. d-states of transition metal compounds. Then the corresponding double counting term in LDA+DMFT Hamiltonian is consistently set in the local Hartree (fully localized limit - FLL) form of the Hubbard model interaction term. We present the results of extensive LDA'+DMFT calculations of densities of states, spectral densities and optical conductivity for most typical representatives of two wide classes of strongly correlated systems in paramagnetic phase: charge transfer insulators (MnO, CoO and NiO) and strongly correlated metals (SrVO3 and Sr2RuO4). It is shown that for NiO and CoO systems LDA'+DMFT qualitatively improves the conventional LDA+DMFT results with FLL type of double counting, where CoO and NiO were obtained to be metals. We also include in our calculations transition metal 4s-states located near the Fermi level missed in previous LDA+DMFT studies of these monooxides. General agreement with optical and X-ray experiments is obtained. For strongly correlated metals LDA$^\prime$+DMFT results agree well with earlier LDA+DMFT calculations and existing experiments. However, in general LDA'+DMFT results give better quantitative agreement with experimental data for band gap sizes and oxygen states positions, as compared to the conventional LDA+DMFT.
description: 13 pages, 11 figures, 1 table. In v2 there some additional clarifications are included
A Practitioner's Approach to Mastitis Microbiology- Acute and Subclinical
Creators: name: Vandamme, Douglas M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: In cases of acute bovine mastitis, rapid treatment is essential to salvaging milk production in the affected quarter and often times in saving the life of the cow. Proper antibiotic therapy and other necessary procedures such as fluid therapy calcium administration must be instituted at the first sign of mastitis. Treatment success or failure is usually determined within the first twenty four hours of onset of signs. Acute cases of mastitis in the bovine generally are caused by coliform organisms although staphylococci and streptococci may be involved occasionally.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Linking processes to community functions : insights into litter decomposition combining fungal metatranscriptomics and environmental NMR profiling
Creators: name: Figueira Rodrigues Guerreiro, Marco Alexandre
name: Kambach, Stephan
name: Stoll, Raphael
name: Brachmann, Andreas
name: Senker, Jürgen
name: Begerow, Dominik
name: Peršoh, Derek
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: In forest ecosystems, decomposition is essential for carbon and nutrient cycling and therefore a key process for ecosystem functioning. During the decomposition process, litter chemistry, involved decomposer organisms, and enzymatic activity change interdependently. Chemical composition of the litter is the most complex and dynamic component in the decomposition process and therefore challenging to assess holistically. In this study, we aimed to characterize chemical shifts during decomposition and link them to changes in decomposer fungal activity. We characterized the chemical composition of freshly fallen autumn leaves of European beech (Fagus sylvatica) and the corresponding leaf litter after 1 year of decomposition by proton nuclear magnetic resonance spectroscopy. We further tested the applicability of spiking experiments for qualitative and quantitative characterization of leaves and litter chemistry. The composition and transcriptional activity of fungal communities was assessed by high-throughput Illumina sequencing in the same litter samples. We were able to distinguish freshly fallen leaves from 1-year-old litter based on their chemical composition. Chemical composition of leaves converged among regions with progressing decomposition. Fungal litter communities differed in composition among regions, but they were functionally redundant according to the expression of genes encoding litter degrading enzymes (CAZymes). Fungi of the saprotrophic genera Mycena and Chalara correlated with transcription of litter-degrading CAZymes in 1-year-old litter. Forestry measures influenced the diversity and transcription rate of the detected CAZymes transcripts in litter. Their expression was primarily predicted by composition of the soluble chemical fraction of the litter. Environmental NMR fingerprints thus proved valuable for inferring ecological contexts. We propose and discuss a holistic framework to link fungal activity, enzyme expression, and chemical composition.
Neriene Blackwall 1833
Creators: name: Tanasevitch, Andrei V.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Neriene

description: Neriene Blackwall, 1833
 Type species: Neriene clathrata (Sundevall, 1830), by subsequent designation.
description: Published as part of Tanasevitch, Andrei V., 2014, New species and records of linyphiid spiders from Laos (Araneae, Linyphiidae), pp. 67-89 in Zootaxa 3841 (1) on page 84, DOI: 10.11646/zootaxa.3841.1.3, http://zenodo.org/record/286780
A redox-active HybG-HypD scaffold complex is required for optimal ATPase activity during [NiFe]-hydrogenase maturation in Escherichia coli
Creators: name: Haase, Alexander
name: Sawers, R. Gary
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: Four Hyp proteins build a scaffold complex upon which the Fe(CN)2CO group of the [NiFe]-cofactor of hydrogenases (Hyd) is made. Two of these Hyp proteins, the redox-active, [4Fe-4S]-containing HypD protein and the HypC chaperone, form the basis of this scaffold complex. Two different scaffold complexes exist in Escherichia coli, HypCD, and the paralogous HybG-HypD complex, both of which exhibit ATPase activity. Apart from a Rossmann fold, there is no obvious ATP-binding site in HypD. The aim of this study, therefore, was to identify amino acid motifs in HypD that are required for the ATPase activity of the HybG-HypD scaffold complex. Amino acid-exchange variants in three conserved motifs within HypD were generated. Variants in which individual cysteine residues coordinating the iron–sulfur ([4Fe-4S]) cluster were exchanged abolished Hyd enzyme activity and reduced ATPase activity but also destabilized the complex. Two conserved cysteine residues, C69 and C72, form part of HypD's Rossmann fold and play a role in HypD's thiol-disulfide exchange activity. Substitution of these two residues individually with alanine also abolished hydrogenase activity and strongly reduced ATPase activity, particularly the C72A exchange. Residues in a further conserved GFETT motif were exchanged, but neither hydrogenase enzyme activity nor ATPase activity of the isolated HybG-HypD complexes was significantly affected. Together, our findings identify a strong correlation between the redox activity of HypD, ATPase activity, and the ability of the complex to mature Hyd enzymes. These results further highlight the important role of thiol residues in the HybG-HypD scaffold complex during [NiFe]-cofactor biosynthesis.
Unusual displacement of HI due to tidal interaction in Arp 181
Creators: name: Sengupta, Chandreyee
name: Dwarakanath, K. S.
name: Saikia, D. J.
name: Scott, T. C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present results from GMRT HI 21 cm line observations of the interacting galaxy pair Arp 181 (NGC 3212 and NGC 3215) at z =0.032. We find almost all of the detected HI (90%) displaced well beyond the optical disks of the pair with the highest density HI located ~70 kpc west of the pair. An HI bridge extending between the optical pair and the bulk of the HI together with their HI deficiencies provide strong evidence that the interaction between the pair has removed most of their HI to the current projected position. HI to the west of the pair has two approximately equal intensity peaks. The HI intensity maximum furthest to the west coincides with a small spiral companion SDSS J102726.32+794911.9 which shows enhanced mid-infrared (Spitzer), UV (GALEX) and H alpha emission indicating intense star forming activity. The HI intensity maximum close to the Arp 181 pair, coincides with a diffuse optical cloud detected in UV (GALEX) at the end of the stellar and HI tidal tails originating at NGC 3212 and, previously proposed to be a tidal dwarf galaxy in formation. Future sensitive HI surveys by telescopes like ASKAP should prove to be powerful tools for identifying tidal dwarfs at moderate to large redshifts to explore in detail the evolution of dwarf galaxies in the Universe.
description: 1 figure
title: Letztbegründung und Geschichte. Schellings Philosophie der Mythologie und Offenbarung
Creators: name: Cürsgen, Dirk
Publisher: name: epubli
Year: 2017

description: Das Buch bietet eine umfassende Rekonstruktion und Gesamtauslegung der Spätphilosophie Friedrich Wilhelm Joseph von Schellings (1775-1854), in der alle wesentlichen Gedanken im systematischen Zusammenhang zur Sprache kommen. Als letzter großer Entwurf der onto-theologischen Metaphysik und in kritischer Auseinandersetzung mit Hegel werden hier noch einmal die großen Themen dieser bestimmenden abendländischen Denkform behandelt und an ihr Ende geführt.
Additional file 1 of The prevalence and socio-behavioural and clinical covariates of oral health related quality of life in Ugandan mothers with and without HIV-1
Creators: name: Birungi, Nancy
name: Fadnes, Lars Thore
name: Engebretsen, Ingunn Marie Stadskleiv
name: Tumwine, James Kashugyera
name: Åstrøm, Anne Nordrehaug
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Table S1. Mothers’ OIDP by HIV status, socio-demographic and self-reported clinical variables. Unadjusted and adjusted OLR and negative binomial regression. Table S2. Evaluation of effects of interaction of covariates* with HIV exposure regressed with oral health impacts.
Characteristics of behavioural addiction in Parkinson’s disease patients with self-reported impulse control disorder and controls matched for levodopa equivalent dose : a matched case–control study
Creators: name: Leplow, Bernd
name: Renftle, Daniela
name: Thomas, Mareike
name: Michaelis, Katja
name: Solbrig, Susanne
name: Maetzler, Walter
name: Berg, Daniela
name: Liepelt-Scarfone, Inga
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Impulse control disorders (ICD) in Parkinson’s disease (PD) frequently occur, not always as a direct consequence of dopaminergic medication. This study investigated premorbid personality traits and behavioural characteristics in non-demented PD patients with self-reported symptoms of ICD (PD-srICD). From a total of 200 non-demented PD patients who filled out questionnaires assessing symptoms and severity of ICD, those were classified as PD-srICD (n = 32) who reported current occurrence of at least one compulsive behaviour (gambling, sexual behaviour, buying behaviour, or eating). As a control group, 32 patients with no self-reported ICD symptoms were matched for levodopa equivalent daily dose. The demographic, clinical, and premorbid personality profiles were compared between both groups. Frequency of psychological characteristics indicating substance use disorder was evaluated in patients with PD-srICD. Patients with PD-srICD were more frequently male, younger at examination, had earlier PD onset, more depression, higher non-motor burden, less quality of life (p < 0.05, respectively), and more frequently reported premorbid sensation seeking/novelty orientation (p = 0.03) and joyful experience of stress (p = 0.04) than patients in the control group. Of patients with PD-srICD, 90.6% reported at least one behavioural characteristic of substance use disorder, most frequently positive expectations following ICD behaviour and illusional beliefs about its behavioural control. Signs of addiction were common among patients with PD-srICD. Therefore, the profile of psychological characteristics in patients with PD-srICD resembled that of patients with substance use disorder. It can be concluded that dopamine replacement therapy (DRT) alone does not account for PD-srICD and that thorough psychological diagnostics are recommended.
Diversity and abundance of the Abnormal chromosome 10 meiotic drive complex in Zea mays
Creators: name: Kanizay, Lisa B.
name: Pyhäjärvi, Tanja
name: Lowry, Elizabeth G.
name: Hufford, Matthew B.
name: Peterson, Daniel G.
name: Ross-Ibarra, Jeffrey
name: Dawe, R. Kelly
Publisher: name: arXiv
Year: 2012
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Maize Abnormal chromosome 10 (Ab10) contains a classic meiotic drive system that exploits asymmetry of meiosis to preferentially transmit itself and other chromosomes containing specialized heterochromatic regions called knobs. The structure and diversity of the Ab10 meiotic drive haplotype is poorly understood. We developed a BAC library from an Ab10 line and used the data to develop sequence-based markers, focusing on the proximal portion of the haplotype that shows partial homology to normal chromosome 10. These molecular and additional cytological data demonstrate that two previously identified Ab10 variants (Ab10-I and Ab10-II) share a common origin. Dominant PCR markers were used with FISH to assay 160 diverse teosinte and maize landrace populations from across the Americas, resulting in the identification of a previously unknown but prevalent form of Ab10 (Ab10-III). We find that Ab10 occurs in at least 75% of teosinte populations at a mean frequency of 15%. Ab10 was also found in 13% of the maize landraces, but does not appear to be fixed in any wild or cultivated population. Quantitative analyses suggest that the abundance and distribution of Ab10 is governed by a complex combination of intrinsic fitness effects as well as extrinsic environmental variability.
title: Neuer YouTube-Kanal der UB Heidelberg: Mit HEIDI und DBIS effizient recherchieren
Creators: name: Homann, Benno
Publisher: name: Heidelberg University Library
Year: 2017

description: Seit Anfang 2017 betreibt die Universitätsbibliothek Heidelberg einen eigenen YouTube-Kanal.Benno Homann, Leiter des Referats für Schulung und Informationskompetenz (RSI), informiert über die Hintergründe.
Economics of Lactation Therapy Based on High Somatic Cell Counts
Creators: name: Erb, H.N.
name: McDermott, M.P.
name: Natzke, R.P.
name: Barnes-Pallesen, F.
name: Bray, D.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: Mastitis is an expensive problem. Much of the problem is attributable to subclinical infections, which are moreprevalent and longer lasting than clinical infections. Data from Virginia4 and the linear scoring work of Shook and Saerrian measured subclinical infections indirectly through somatic cell counts (SCC); these analyses showed increasing losses of milk as SCC increased. New infections can be prevented through hygiene and dry cow therapy. Existing infections can be eliminated from the herd by culling, but that means the loss of a cow. They can be eliminated often by dry cow therapy, but that means that nothing was done about the infection until the lactation was finished. On the other hand, infections sometimes can be cleared by lactation therapy.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
Neriene birmanica Thorell 1887
Creators: name: Tanasevitch, Andrei V.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Neriene
Neriene birmanica

description: Neriene birmanica (Thorell, 1887)
Figs 59–65
 Material examined. 3♂, 4♀, LAOS, Luang Nam Tha Prov., Luang Nam Tha, between Ban Tavan 1, 581 m a.s.l., 20°58.702'N 101°28.686'E and Ban Tavan 2, 657 m a.s.l., 20°58.872'N 101°28.875'E, valley with stream, disturbed primary forest, by hand, sieving, sweepnet, 9.XI.2004, leg. P. Jäger & V. Vedel. 1♀, Luang Prabang Prov., SE Luang Prabang, Nam Khan, Xieng Ngeun Distr., Ban Keng Koung, 372 m a.s.l., 19°40'963''N 102°18'442''E, disturbed forest, valley, waterfall, dry stream bed, by hand, at night, 25.II.2008, leg. P. Jäger. 3♂, 2♀, same data, 372 m a.s.l., 19°40'963''N 102°18'442''E, above waterfall, close to stream, under stones, at leaves, at rock, by hand, 23.II.2008, leg. P. Jäger. 1♀, Bolikhamsay Prov., Lak Sao (1), 18°11'09,0''N 104°53'55.0''E, 500 m a.s.l., in cave, at day, by hand, 6.III.2010, leg. P. Jäger & J. Martens. 1♀, Lak Sao (5), 18°12'41.6'' 104°50'26.6''E, 551 m a.s.l., cool valley, bed of a stream, dry, at day, sieving, leg. 10.11.2009, P. Jäger & S. Bayer. 1♀, Lak Sao (4), 18°13'38,2''N 104°44'47,3''E, 534 m a.s.l., inside cave and cave entrance, at day, by hand, 9.XI.2009, leg. P. Jäger & S. Bayer.
 Distribution. The species is known from China, India, Kashmir, Myanmar, Bali (Platnick 2014) and Laos.
description: Published as part of Tanasevitch, Andrei V., 2014, New species and records of linyphiid spiders from Laos (Araneae, Linyphiidae), pp. 67-89 in Zootaxa 3841 (1) on page 84, DOI: 10.11646/zootaxa.3841.1.3, http://zenodo.org/record/286780
Additional file 1 of Frontline healthcare workers’ experiences in implementing the TB-DM collaborative framework in Northern Ghana
Creators: name: Salifu, Rita Suhuyini
name: Hlongwana, Khumbulani W.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1.
Characterization of neuroendocrine regulation- and metabolism-associated molecular features and prognostic indicators with aid to clinical chemotherapy and immunotherapy of patients with pancreatic cancer
Creators: name: Zhang, Biao
name: Yuan, Qihang
name: Zhang, Bolin
name: Li, Shuang
name: Wang, Zhizhou
name: Liu, Hangyu
name: Meng, Fanyue
name: Chen, Xu
name: Shang, Dong
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: The worldwide prevalence of pancreatic cancer has been rising in recent decades, and its prognosis has not improved much. The imbalance of substance and energy metabolism in tumour cells is among the primary causes of tumour formation and occurrence, which is often controlled by the neuroendocrine system. We applied Cox and LASSO regression analysis to develop a neuroendocrine regulation- and metabolism-related prognostic risk score model with three genes (GSK3B, IL18 and VEGFA) for pancreatic cancer. TCGA dataset served as the training and internal validation sets, and GSE28735, GSE62452 and GSE57495 were designated as external validation sets. Patients classified as the low-risk population (category, group) exhibited considerably improved survival duration in contrast with those classified as the high-risk population, as determined by the Kaplan-Meier curve. Then, we combined all the samples, and divided them into three clusters using unsupervised clustering analysis. Unsupervised clustering, t-distributed stochastic neighbor embedding (t-SNE), and principal component analysis (PCA) were further utilized to demonstrate the reliability of the prognostic model. Moreover, the risk score was shown to independently function as a predictor of pancreatic cancer in both univariate and multivariate Cox regression analyses. The results of gene set enrichment analysis (GSEA) illustrated that the low-risk population was predominantly enriched in immune-associated pathways. “ESTIMATE” algorithm, single-sample GSEA (ssGSEA) and the Tumor Immune Estimation Resource (TIMER) database showed immune infiltration ratings were enhanced in the low-risk category in contrast with the high-risk group. Tumour immune dysfunction and exclusion (TIDE) database predicted that immunotherapy for pancreatic cancer may be more successful in the high-risk than in the low-risk population. Mutation analysis illustrated a positive link between the tumour mutation burden and risk score. Drug sensitivity analysis identified 44 sensitive drugs in the high- and low-risk population. GSK3B expression was negatively correlated with Oxaliplatin, and IL18 expression was negatively correlated with Paclitaxel. Lastly, we analyzed and verified gene expression at RNA and protein levels based on GENPIA platform, HPA database and quantitative real-time PCR. In short, we developed a neuroendocrine regulation- and metabolism-associated prognostic model for pancreatic cancer that takes into account the immunological microenvironment and drug sensitivity.
A Self-Organized Neural Comparator
Creators: name: Ludueña, Guillermo A.
name: Gros, Claudius
Publisher: name: arXiv
Year: 2012
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Biological sciences
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Learning algorithms need generally the possibility to compare several streams of information. Neural learning architectures hence need a unit, a comparator, able to compare several inputs encoding either internal or external information, like for instance predictions and sensory readings. Without the possibility of comparing the values of prediction to actual sensory inputs, reward evaluation and supervised learning would not be possible. Comparators are usually not implemented explicitly, necessary comparisons are commonly performed by directly comparing one-to-one the respective activities. This implies that the characteristics of the two input streams (like size and encoding) must be provided at the time of designing the system. It is however plausible that biological comparators emerge from self-organizing, genetically encoded principles, which allow the system to adapt to the changes in the input and in the organism. We propose an unsupervised neural circuitry, where the function of input comparison emerges via self-organization only from the interaction of the system with the respective inputs, without external influence or supervision. The proposed neural comparator adapts, unsupervised, according to the correlations present in the input streams. The system consists of a multilayer feed-forward neural network which follows a local output minimization (anti-Hebbian) rule for adaptation of the synaptic weights. The local output minimization allows the circuit to autonomously acquire the capability of comparing the neural activities received from different neural populations, which may differ in the size of the population and in the neural encoding used. The comparator is able to compare objects never encountered before in the sensory input streams and to evaluate a measure of their similarity, even when differently encoded.
Use of Individual Cow Somatic Cell Counts and Bulk Tank Samples to Monitor Herd Mastitis Status
Creators: name: Hueston, William D.
name: Heider, Lawrence E.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 1984

description: With the advent of automated cell counting, there has been a proliferation of milk somatic cell count (SCC) data for both bulk tank samples and individual cows. The optimal use of this data in monitoring mastitis is still being debated. The purpose of this paper is to discuss the use of SCC data from both individual cow and bulk tank samples for monitoring mastitis on a herd basis.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 1984
title: Georg Zehfuss: Sein Leben und seine Werke
Creators: name: Strobl, Walter
Publisher: name: Heidelberg University Library
Year: 2018

description: Es ist viel über den historischen Ursprung der Definition des Tensorproduktes von Matrizen geschrieben worden, so haben ihn einige Autoren Kronecker und anderen Autoren Zehfuss zugeschrieben. Aber bis jetzt waren bibliographische Informationen von Georg Zehfuss (1832-1901) knapp und die Liste seiner Veröffentlichungen unvollständig, so dass schwer zu verstehen ist, dass ein so unbekannter Mathematiker hier mitbestimmend war. 
Wir beabsichtigen hier diese Lücke auszufüllen, indem wir Daten aus verschiedenen bekannten und neuen Quellen sammeln, gruppieren, kategorisieren und kommentieren. Dies umfasst biographische Daten, seine Lehrer und Tutoren, viele seiner Publikationen und die Auswirkungen einiger seiner Errungenschaften in Mathematik und Physik. Die Schlussfolgerung ist, dass der Beitrag von Zehfuss zur Mathematik sich nicht auf die Definition vom Tensorprodukt von Matrizen beschränkt ist, da es weitere Beiträge zur Mathematik und nicht nur zur Determinantenttheorie, auch zur Physik von ihm gibt, und abgesehen von seinen Beiträgen zur Bildung von späteren Ingenieuren an höheren Gewerbeschulen mit seiner Lehrtätigkeit und mit seinen Büchern.
title: Gumbel, Emil Julius (18.7.1891 - 10.9.1966)
Creators: name: Dörflinger, Gabriele
Publisher: name: Heidelberg University Library
Year: 2018

description: Der Statisker und Pazifist Emil Julius Gumbel lehrte von 1923 bis 1932 an der Heidelberger Universität. Kritische Äußerungen zum 1. Weltkrieg führten 1932 zum Entzug der Lehrbefugnis.

Die Materialsammlung enthält: 1. Lexikonartikel, 2. Biographische Informationen, 3. Umfassende Informationen zu seiner Heidelberger Zeit, 4. Bestandsnachweise zum Werk (gedruckt / digital) und 5. Hinweise zu Bibliographien. Der Anhang enth. u.a.  das Plädoyer von Gustav Radbruch im Disziplinarverfahren von 1932.
Additional file 2 of Frontline healthcare workers’ experiences in implementing the TB-DM collaborative framework in Northern Ghana
Creators: name: Salifu, Rita Suhuyini
name: Hlongwana, Khumbulani W.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 2.