cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Longitudinal Research on Aging Drivers (LongROAD): study design and methods
Creators: name: Li, Guohua
name: Eby, David W.
name: Santos, Robert
name: Mielenz, Thelma J.
name: Molnar, Lisa J.
name: Strogatz, David
name: Betz, Marian E.
name: DiGuiseppi, Carolyn
name: Ryan, Lindsay H.
name: Jones, Vanya
name: Pitts, Samantha I.
name: Hill, Linda L.
name: DiMaggio, Charles J.
name: LeBlanc, David
name: Andrews, Howard F.
name: LongROAD Research Team
Publisher: name: Columbia University
Year: 2017
Subjects: Older automobile drivers
Motor vehicle driving--Safety measures
Epidemiology
Transportation

description: Background:
As an important indicator of mobility, driving confers a host of social and health benefits to older adults. Despite the importance of safe mobility as the population ages, longitudinal data are lacking about the natural history and determinants of driving safety in older adults.

Methods:
The Longitudinal Research on Aging Drivers (LongROAD) project is a multisite prospective cohort study designed to generate empirical data for understanding the role of medical, behavioral, environmental and technological factors in driving safety during the process of aging.

Results:
A total of 2990 active drivers aged 65–79 years at baseline have been recruited through primary care clinics or health care systems in five study sites located in California, Colorado, Maryland, Michigan, and New York. Consented participants were assessed at baseline with standardized research protocols and instruments, including vehicle inspection, functional performance tests, and “brown-bag review” of medications. The primary vehicle of each participant was instrumented with a small data collection device that records detailed driving data whenever the vehicle is operating and detects when a participant is driving. Annual follow-up is being conducted for up to three years with a telephone questionnaire at 12 and 36 months and in-person assessment at 24 months. Medical records are reviewed annually to collect information on clinical diagnoses and healthcare utilization. Driving records, including crashes and violations, are collected annually from state motor vehicle departments. Pilot testing was conducted on 56 volunteers during March–May 2015. Recruitment and enrollment were completed between July 2015 and March 2017.

Conclusions:
Results of the LongROAD project will generate much-needed evidence for formulating public policy and developing intervention programs to maintain safe mobility while ensuring well-being for older adults.
Alfred Wieczorek / Patrick Perin (Hrsg.), Das Gold der Barbarenfürsten - Schätze aus Prunkgräbern des 5. Jahrhunderts n. Chr. zwischen Kaukasus und Gallien
Creators: name: Schnurbein, Rüdiger Von
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2021

description: Rezension zu: Alfred Wieczorek / Patrick Perin (Hrsg.), Das Gold der Barbarenfürsten - Schätze aus Prunkgräbern des 5. Jahrhunderts n. Chr. zwischen Kaukasus und Gallien. Begleitbuch zur Ausstellung des Reiss-Museums Mannheim und des Musée des Antiquités Narionales, Château de Saint-Germain-en-Laye. Theiss Verlag, Stuttgart 2001, 184 Seiten, 240 meist farbige Abbildungen
description: Acta Praehistorica et Archaeologica, Bd. 33 (2001)
title: Inferring patterns from tagging surveys:sampling from tracking data
Creators: name: Royer, Francois
name: Gaspar, Philippe
name: Calmettes, Beatriz
name: Senina, Inna
name: Lehodey, Patrick
Publisher: name: ASC 2009 - Theme session B
Year: 2024
Subjects: Fisheries and aquaculture
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.This paper presents a method to efficiently derive samples from movement data gathered by electronic tag datasets. This, in turn, can beused to facilitate inference at an individual and population level. The accumulation of large, heterogeneous electronic datasets over the years raises several issues regarding their processing, analysis and interpretation: deriving trajectory samples can help solve questions about temporal variability, such as 'are my dispersion patterns similar over all these years?', or 'Are two years similar, despite the difference in sampling size and tag technology?'. The sampler described herein leverages the Kalman filter and allows to derive samples from the hidden track of an animal in order to 1) perform inference in a Bayesian framework, and 2) build samples at aggregate levels. The sampler is efficient and appears to show adequate convergence and mixing properties. This preliminary approach gives confidence in its application to larger, more complex cases.
Mamoun Fansa (Hrsg.), Über allen Fronten Nordwestdeutschland zwischen Augustus und Karl dem Großen
Creators: name: Neumayer, Heino
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2021

description: Rezension zu: Mamoun Fansa (Hrsg.), Über allen Fronten Nordwestdeutschland zwischen Augustus und Karl dem Großen. Arch. Min. aus Nordwestdeutschland, Beih. 26. Isensee Verlag, Oldenburg 1999. 293 Seiten mit 196 Abbildungen
description: Acta Praehistorica et Archaeologica, Bd. 33 (2001)
Letter from V.V. Shevoroshkin to Emmett L. Bennett Jr., October 19, 1976
Creators: name: Shevoroshkin, V.V.
Publisher: name: The University of Texas at Austin
Year: 1976
Subjects: Emmett L. Bennett, Jr. Collection
Emmett L. Bennett, Jr. Collection--Correspondence
Emmett L. Bennett, Jr. Collection--Correspondence--V.V. Shevoroshkin
Nestor--publication
Yale University
Department of Linguistics

description: Shevoroshkin requests a copy of the Nestor publication from Bennett.
Gold für die Ewigkeit - Das germanische Fürstengrab von Gommern
Creators: name: Leube, Achim
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2021

description: Rezension zu: Gold für die Ewigkeit - Das germanische Fürstengrab von Gommern. Begleitband zur Sonderausstellung im Landesmuseum für Vorgeschichte Halle (Saale), 18.10.2000 bis 28.02.2001/Landesamt für Archäologie Sachsen-Anhalt; Landesmuseum für Vorgeschichte. Hrsg. von Siegfried Fröhlich. Bearb.: M. Sailer; A. Roeder. Landesamt für Archäologie (Halle 2000)
description: Acta Praehistorica et Archaeologica, Bd. 33 (2001)
Space & Climate collaboration United States of America and the Netherlands
Creators: name: van Amerongen, Aaldert
name: Bowman, Kevin
name: Dammers, Enrico
name: Denier van der Gon, Hugo
name: van Diedenhoven, Bastiaan
name: FROST, GREGORY
name: Joiner, Joanna
name: Jucks, Kenneth
name: Knobelspiesse, Kirk
name: Krotkov, Nickolay
name: Levelt, Pieternel
name: Lorenzoni, Laura
name: Maasakkers, Bram
name: Salawitch, Ross
name: da Silva, Arlindo
name: Swartz, William
name: Veefkind, Pepijn
name: Worden, Helen
name: van Zadelhoff, Gerd-Jan
Publisher: name: Zenodo
Year: 2024

description: Scientists from the United States and the Netherlands have identified opportunities to explore Scientists from the United States and the Netherlands have identified opportunities to explore avenues to further enhance the US-NL partnership, in the fields of clouds and aerosols, avenues to further enhance the US-NL partnership, in the fields of clouds and aerosols, greenhouse gases and reactive gases. In total 10 cross cutting topics between these fields have greenhouse gases and reactive gases. In total 10 cross cutting topics between these fields have been identified that will benefit from collaborative research. The subject matter experts have been identified that will benefit from collaborative research. The subject matter experts have made recommendations, that can be summarized in the following three categories:

Joint development of satellite missions and sub-orbital campaigns, including the follow on for OMI/TROPOMI and SPEXone, and the study of reactive nitrogen.

Joint research to reduce biases in satellite data, by improving methods and algorithms, calibration and validation studies, as well using the satellite data to enhance our knowledge on air quality, climate and biodiversity.

Organizing scientific workshops and exchanging students and scientists, to exchange ideas and to build the US-NL partnership for the future.
Slanging the emperor : Honoré Daumier’s Le Monde illustré caricatures of the 1867 Exposition Universelle
Creators: name: Stephens, Russell James
Publisher: name: University of British Columbia
Year: 2013

description: The staging of the greatest spectacle of Napoléon III’s Second Empire, the1867 Exposition Universelle, did not go uncontested. In a series of wood engravings produced for the conservative magazine Le Monde illustré, and which stand as testimony to the power of images, the caricaturist Honoré Daumier challenged the Emperor’s World’s Fair and the Fete Imperiale rhetoric it espoused. Two caricatures realized from the Le Monde illustré series evidence Daumier’s subversive strategies to circumvent Napoléon III’s censorship and fashion a defiant political criticism of the régime. Foremost amongst these I argue is Daumier’s deployment of slang or argot --the “unofficial” language of the streets and associated with suppressed members of the working classes under the Second Empire--prostitutes, ragpickers, and ouvriers. Daumier’s caricatures set these marginalized argot voices into collision with the “official” rhetoric of the Emperor’s World’s Fair. Drawing on Bakhtin’s concepts of Menippean satire and the ‘carnivalesque this thesis also explores how Daumier’s images mock and ridicule representations of authority and dogma. Crucially, however, stepping past the practice of a satire of negation, Daumier’s caricatures can be understood as refashioning the utopian promise and regenerative dimension of laughter derived from the ancient past into something more distinctly modern. The Second Empire was not only a time of class conflict but an era characterized by a lost revolutionary possibility. Indeed, it was the brutal reality of the unrealized ambitions of large segments of the working classes crushed in June 1848 that permeates the history of this time. Daumier’s World’s Fair images were produced at a shifting historical moment in the mid 1860’s of increasing political consciousness of the working classes. Glimpsed in this context, Daumier’s caricatures can be read at one level as “counter images” to the Exposition, disarming the politically anesthetizing phantasmagoria of the Napoléon III’s Fair, rooted in Saint- Simonian notions of progress. However, at another level they can also be understood through their mobilization of the voice of argot and the hidden suppressed language of the working classes as refashioning the fearless utopian promise of laughter as a weapon of class struggle.
title: Linking oceanography and bluefin tuna movements in the Northwest Atlantic
Creators: name: Galuardi, Benjamin
name: Royer, François
name: Lutcavage, Molly
Publisher: name: ASC 2009 - Theme session B
Year: 2024
Subjects: Fisheries and aquaculture
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.For highly mobile predators such as Atlantic bluefin tuna (ABFT), appropriate oceanographic structure and biophysical interactions create dynamic feeding opportunities. The location and persistence of appropriate watermass features along their migration routes should influence ABFT residence times, energy stores, larval and reproductive success, and vulnerability to capture. Bluefin tuna may seek specific physical conditions to aid physiological functions such as thermoregulation and food assimilation. Gutenkunst et al. (2007) previously identified two movement modes, traveling and foraging, on coastal foraging grounds. However, time and spatial scales were limited (e.g., 48 h, 150 km tracks). Recent advances in satellite and electronic tagging technology and light based geolocation have revealed the scope and complexity of ABFT distributions. Using spatial and behavioral results obtained from adult ABFT tagged with popup archival satellite tags for up to one year in the NW Atlantic, we examined the relationship between persistent oceanographic features and behavior type and depth patterns, and interplay of ABFT depth patterns and behavior. By developing a complete picture of habitat utilization of ABFT, we hope to better understand long term shifts in their distribution and abundance, and contribute to population rebuilding efforts through better understanding of their ecosystem. Our approach utilizes a framework useful for combining geolocations with depth data and the physical environment.
Depression, antidepressants and driving safety
Creators: name: Hill, Linda L.
name: Lauzon, Vanessa L.
name: Winbrock, Elise L.
name: Li, Guohua
name: Chihuri, Stanford T.
name: Lee, Kelly C.
Publisher: name: Columbia University
Year: 2017
Subjects: Antidepressants
Traffic accidents
Depression, Mental
Motor vehicle driving--Safety measures

description: Background:
The purpose of this study was to review the reported associations of depression and antidepressants with motor vehicle crashes.

Purpose:
A literature search for material published in the English language between January, 1995, and October, 2015, in bibliographic databases was combined with a search for other relevant material referenced in the retrieved articles.

Methods:
Retrieved articles were systematically reviewed for inclusion criteria: 19 epidemiological studies (17 case-control and 2 cohort studies) fulfilled the inclusion criteria by estimating the crash risk associated with depression and/or psychotropic medications in naturalistic settings.

Results:
The estimates of the odds ratio (OR) of crash involvement associated with depression ranged from 1.78 to 3.99. All classes of antidepressants were reported to have side effects with the potential to affect driving safety. The majority of studies of antidepressant effects on driving reported an elevated crash risk, and ORs ranged from 1.19 to 2.03 for all crashes, and 3.19 for fatal crashes. In meta-analysis, depression was associated with approximately 2-fold increased crash risk (summary OR = 1.90; 95% CI, 1.06 to 3.39), and antidepressants were associated with approximately 40% increased crash risk (summary OR = 1.40; 95%CI, 1.18 to 1.66).

Conclusion:
Based on the findings of the studies reviewed, depression, antidepressants or the combination of depression and antidepressants may pose a potential hazard to driving safety. More research is needed to understand the individual contributions of depression and the medications used to treat depression.
Critical scaling of finite temperature QED_3 in anisotropic space-time
Creators: name: Bonnet, Jacqueline A.
name: Fischer, Christian S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We investigate the scaling behavior of the critical temperature of anisotropic QED in 2+1 dimensions with respect to a variation of the number of fermions N_f. To this end we determine the order parameter of the chiral transition of the theory from a set of (truncated) Dyson-Schwinger equations for the fermion propagator formulated in a finite volume. We verify the validity of previously determined universal power laws for the scaling behavior of the critical temperature with N_f. We furthermore study the variation of the corresponding critical exponent with the degree of anisotropy and find considerable variations.
description: 7 pages, 6 figures v2: clarifications added, typos corrected, version accepted by Phys. Lett. B
Ralf Busch / Torsten Capelle / Friedrich Laux, Opferplatz und Heiligtum. Kult der Vorzeit in Norddeutschland
Creators: name: Hänsel, Alix
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2021

description: Rezension zu: Ralf Busch / Torsten Capelle / Friedrich Laux, Opferplatz und Heiligtum. Kult der Vorzeit in Norddeutschland. Begleitschrift zu einer Ausstellung in Hamburg-Harburg, Helms-Museum, und Frankfurt a. Main, Museum für Vor- und Frühgeschichte. Veröffentlichungen des Helms-Museums, Hamburger Museum für Archäologie und die Geschichte Harburgs 86. Wachholrz Verlag Neumünster 2000
description: Acta Praehistorica et Archaeologica, Bd. 33 (2001)
Alfred Bernhard-Walcher, Günther Dembski, Kurt Gschwantler, Vassos Karageorghis. Die Sammlung Zyprischer Antiken im Kunsthistorischen Museum
Creators: name: Brönner, Melitta
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2021

description: Rezension zu: Alfred Bernhard-Walcher, Günther Dembski, Kurt Gschwantler, Vassos Karageorghis. Die Sammlung Zyprischer Antiken im Kunsthistorischen Museum. The Collection of Cypriote Antiquities in the Kunsthistorisches Museum. Sammlungskataloge des Kunsthistorischen Museums. Bd. 2. Antikensammlung. Hrsg. Wilfried Seipel (Kunsthistorisches Museum Wien 1999). 238 Seiten, 19 Textabbildungen, vorwiegend farbig, 125 farbige Katalogabbildungen, 1 Karte
description: Acta Praehistorica et Archaeologica, Bd. 33 (2001)
Solving the At-Most-Once Problem with Nearly Optimal Effectiveness
Creators: name: Kentros, Sotirios
name: Kiayias, Aggelos
Publisher: name: arXiv
Year: 2011
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences
subject: F.1.2; F.2.m

description: We present and analyze a wait-free deterministic algorithm for solving the at-most-once problem: how m shared-memory fail-prone processes perform asynchronously n jobs at most once. Our algorithmic strategy provides for the first time nearly optimal effectiveness, which is a measure that expresses the total number of jobs completed in the worst case. The effectiveness of our algorithm equals n-2m+2. This is up to an additive factor of m close to the known effectiveness upper bound n-m+1 over all possible algorithms and improves on the previously best known deterministic solutions that have effectiveness only n-log m o(n). We also present an iterative version of our algorithm that for any $m = O\left(\sqrt[3+ε]{n/\log n}\right)$ is both effectiveness-optimal and work-optimal, for any constant $ε> 0$. We then employ this algorithm to provide a new algorithmic solution for the Write-All problem which is work optimal for any $m=O\left(\sqrt[3+ε]{n/\log n}\right)$.
description: Updated Version. A Brief Announcement was published in PODC 2011. An Extended Abstract was published in the proceeding of ICDCN 2012. A full version was published in Theoretical Computer Science, Volume 496, 22 July 2013, Pages 69 - 88
Studying a Highly Magnified Lensed Galaxy at z~2.8 with ALMA
Creators: name: Cornil-Baïotto, Carla
name: Motta, Verónica
name: Ibar, Eduardo
name: Mahler, Guillaume
Publisher: name: Zenodo
Year: 2023

description: The nature of star formation in high-z galaxies and the physical properties of the interstellar medium in which it is taking place are not very well understood as yet. Observations have shown that high-z star-forming galaxies often exhibit turbulent, clumpy, rotating discs, yet the limitations of current telescopes hinder the study of individual star-forming regions within these galaxies. The strong lensing phenomenon magnifies background galaxies located behind rich galaxy clusters, providing an excellent opportunity to study distant sources with enhanced resolution and flux. A notable case is the brightest lensed submm galaxy at z~2.8 behind the massive Bullet Cluster, which has an exceptional differential magnification up to 50 (SMMJ0658, z = 2.778). This poster presents the ALMA data reduction of SMMJ0658 (2015.1.01559.S) with CASA, including the CO(3-2) line moment maps, and the reconstructed lensed galaxy in the source plane using the software Lenstool, and its Python wrapper PyLenstool.
Reliability of Imaging-based Measures of Tumor 'Mass-Effect' -- Evidence from a Computational Study
Creators: name: Abler, Daniel
name: Büchler, Philippe
name: Rockne, Russell C.
Publisher: name: Zenodo
Year: 2018
Subjects: glioma
mass-effect
mathematical oncology
mechanically-coupled tumor growth
computational study

description: Elevated tumor mass-effect is associated to poor prognosis in GBM [1,2]. However, tumor mass-effect is poorly quantified in clinical practice. Recently, Steed et al. [2] proposed ‘Lateral ventricle displacement’ (LVd), defined as the change in center-of-mass position of the lateral ventricles between an undeformed reference and the tumor-bearing anatomy, as quantitative imaging measure of mass-effect. They found that the magnitude of LVd in GBM patients can be associated with overall survival. These results show the clinical importance of tumor mass-effect in GBM, warranting robust clinical measures. This study characterizes image-derived estimates of tumor mass-effect by their ability to measure mass-effect accurately and reliably. We use a mathematical model to simulate tumor growth, which allows us to control and objectively quantify ‘mass-effect’ [3]. For given simulation parameters and growth location, we compute estimates of mass-effect from anatomical deformation during the growth process. We use multiple regression analysis to evaluate the ability of different estimates to explain the tumor’s objective mass-effect, measured by the tumor-induced pressure on the skull. References: [1] Gamburg et al. IJROBP, 2000, 48, 5: 1359–62 [2] Steed et al. Scientific Reports, 2018, 8: 2827 [3] Abler et al. Neuro-Oncology, 2017, 19, suppl 6: vi245.
Additional file 1 of A comprehensive medical Spanish curriculum model: the Vida Medical Spanish Curriculum
Creators: name: Chang, Kyle E.
name: Lewis, Jennifer
name: Lopez Vera, Alexandra
Publisher: name: figshare
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Interaction of marijuana and alcohol on fatal motor vehicle crash risk: a case–control study
Creators: name: Chihuri, Stanford T.
name: Li, Guohua
name: Chen, Qixuan
Publisher: name: Columbia University
Year: 2017
Subjects: Traffic accidents
Drinking and traffic accidents
Marijuana
Drug interactions
Traffic fatalities

description: Background:
Concurrent use of marijuana and alcohol in drivers is of increasing concern but its role in crash causation has not been well understood.

Methods:
Using a case–control design, we assessed the individual and joint effects of marijuana and alcohol use on fatal crash risk. Cases (n = 1944) were drivers fatally injured in motor vehicle crashes in the United States at specific times in 2006, 2007 and 2008. Controls (n = 7719) were drivers who participated in the 2007 National Roadside Survey of Alcohol and Drug Use by Drivers.

Results:
Overall, cases were significantly more likely than controls to test positive for marijuana (12.2% vs. 5.9%, p
title: Simulated archival tagging programme for albacore tuna in the North East Atlantic including an analysis of factors affecting tag recovery
Creators: name: Cosgrove, Ronan
name: Arregi, Igor
name: Brophy, Deirdre
name: Arrizabalaga, Haritz
name: de Zarate, Victoria Ortiz
name: Griffin, Nigel
Publisher: name: ASC 2009 - Theme session B
Year: 2024
Subjects: Fisheries and aquaculture
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.With annual landings worth approximately €60 million, albacore tuna (Thunnus alalunga) is a highly commercially important species in the North Atlantic. Stock status has declined in recent years, however, with the latest stock assessment categorising the stock as overfished. Very little information is available on the behaviour of fish in relation to environmental variables, and evidence of the existence of sub populations within the North Atlantic is increasing. These issues which have major implications for the stock assessment process could be addressed by electronic tagging but no information is available on the survivability of albacore tuna carrying archival tags. This study aimed to assess the physiological capability of juvenile albacore to carry archival tags. Also, an ICCAT conventional tag database was analysed to examine factors at the point of release which affect recovery, which could boost recovery rates in future tagging programmes
Superembedding methods for 4d N-extended SCFTs
Creators: name: Maio, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider the embedding method of the superconformal group in four dimensions in the case of extended supersymmetry, hence generalizing the recent work of Goldberger, Skiba and Son which was restricted at N=1. Moreover, we work out explicitly the case of N=2 chiral superfields in four dimensions, putting the component fields in correspondence with Pascal's pyramid at layer N. This correspondence is a generic property of the N-extended chiral sector.
description: 26 pages; references added; published version
FCNC, CP violation and implications for some rare decays in an SU(4)_L X U(1)_X extension of the standard model
Creators: name: Jaramillo, Alejandro
name: Sanchez, Luis A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Extensions of the standard model (SM) with gauge symmetry SU(3)_c X SU(4)_L X U(1)_X (3-4-1 extensions) where anomaly cancellation takes place between the fermion families (three-family models) predict the existence of two new heavy neutral gauge bosons which transmit flavor changing neutral currents (FCNC) at tree-level. In this work, in the context of a three-family 3-4-1 extension which does not contain particles with exotic electric charges, we study the constraints coming from neutral meson mixing on the parameters of the extension associated to tree level FCNC effects. Taking into account experimental measurements of observables related to K and B meson mixing and including new CP-violating phases, we study the resulting bounds for angles and phases in the mixing matrix for the down-quark sector, as well as the implications of these bounds for the modifications in the amplitudes of the clean rare decays K^+ -> π^+ \barνν, K_{L} -> π^0 ν\barν, K_L -> π^0 l^+ l^- (l=e,μ) and B_{d/s} -> μ^+ μ^-.
description: 23 pages, 11 figures. Renormalization group QCD effects on flavor changing observables corrected. References added. Version accepted for publication in Phys. Rev. D
Additional file 2 of A comprehensive medical Spanish curriculum model: the Vida Medical Spanish Curriculum
Creators: name: Chang, Kyle E.
name: Lewis, Jennifer
name: Lopez Vera, Alexandra
Publisher: name: figshare
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2.
Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study
Creators: name: Sun, Xiangqing
name: Chandar, Apoorva K.
name: Canto, Marcia I.
name: Thota, Prashanthi N.
name: Brock, Malcom
name: Shaheen, Nicholas J.
name: Beer, David G.
name: Wang, Jean S.
name: Falk, Gary W.
name: Iyer, Prasad G.
name: Abrams, Julian A.
name: Venkat-Ramani, Medha
name: Veigl, Martina
name: Miron, Alexander
name: Willis, Joseph
name: Patil, Deepa T.
name: Nalbantoglu, Ilke
name: Guda, Kishore
name: Markowitz, Sanford D.
name: Zhu, Xiaofeng
name: Elston, Robert
name: Chak, Amitabh
Publisher: name: Columbia University
Year: 2017
Subjects: Genomics
Barrett's esophagus
Adenocarcinoma
African Americans
Human gene mapping

description: Background:
Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) are far more prevalent in European Americans than in African Americans. Hypothesizing that this racial disparity in prevalence might represent a genetic susceptibility, we used an admixture mapping approach to interrogate disease association with genomic differences between European and African ancestry.

Methods:
Formalin fixed paraffin embedded samples were identified from 54 African Americans with BE or EAC through review of surgical pathology databases at participating Barrett’s Esophagus Translational Research Network (BETRNet) institutions. DNA was extracted from normal tissue, and genotyped on the Illumina OmniQuad SNP chip. Case-only admixture mapping analysis was performed on the data from both all 54 cases and also on a subset of 28 cases with high genotyping quality. Haplotype phases were inferred with Beagle 3.3.2, and local African and European ancestries were inferred with SABER plus. Disease association was tested by estimating and testing excess European ancestry and contrasting it to excess African ancestry.

Results:
Both datasets, the 54 cases and the 28 cases, identified two admixture regions. An association of excess European ancestry on chromosome 11p reached a 5% genome-wide significance threshold, corresponding to -log10(P) = 4.28. A second peak on chromosome 8q reached -log10(P) = 2.73. The converse analysis examining excess African ancestry found no genetic regions with significant excess African ancestry associated with BE and EAC. On average, the regions on chromosomes 8q and 11p showed excess European ancestry of 15% and 20%, respectively.

Conclusions:
Chromosomal regions on 11p15 and 8q22-24 are associated with excess European ancestry in African Americans with BE and EAC. Because GWAS have not reported any variants in these two regions, low frequency and/or rare disease associated variants that confer susceptibility to developing BE and EAC may be driving the observed European ancestry association evidence.
Cosmological Radio Emission induced by WIMP Dark Matter
Creators: name: Fornengo, N.
name: Lineros, R.
name: Regis, M.
name: Taoso, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a detailed analysis of the radio synchrotron emission induced by WIMP dark matter annihilations and decays in extragalactic halos. We compute intensity, angular correlation, and source counts and discuss the impact on the expected signals of dark matter clustering, as well as of other astrophysical uncertainties as magnetic fields and spatial diffusion. Bounds on dark matter microscopic properties are then derived, and, depending on the specific set of assumptions, they are competitive with constraints from other indirect dark matter searches. At GHz frequencies, dark matter sources can become a significant fraction of the total number of sources with brightness below the microJansky level. We show that, at this level of fluxes (which are within the reach of the next-generation radio surveys), properties of the faint edge of differential source counts, as well as angular correlation data, can become an important probe for WIMPs.
description: 19 pages, 26 figures. v2: comments and references added, to appear in JCAP
The Canada Day Theorem
Creators: name: Gomez, Daniel
name: Lundmark, Hans
name: Szmigielski, Jacek
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The Canada Day Theorem is an identity involving sums of $k \times k$ minors of an arbitrary $n \times n$ symmetric matrix. It was discovered as a by-product of the work on so-called peakon solutions of an integrable nonlinear partial differential equation proposed by V. Novikov. Here we present another proof of this theorem, which explains the underlying mechanism in terms of the orbits of a certain abelian group action on the set of all $k$-edge matchings of the complete bipartite graph $K_{n,n}$.
description: 16 pages. pdfLaTeX + AMS packages + TikZ. Fixed a hyperlink problem and a few typos
Neutral evolution of drug resistant colorectal cancer cell populations is independent of their KRAS status
Creators: name: Blagoev, Krastan B.
name: Wilkerson, Julia
name: Burotto, Mauricio
name: Kim, Chul
name: Espinal-Dominguez, Edward
name: Garcia-Alfonso, Pilar
name: Alimchandani, Meghna
name: Miettinen, Markku
name: Blanco-Codesido, Montserrat
name: Fojo, Antonio Tito
Publisher: name: Columbia University
Year: 2017
Subjects: Drug resistance in cancer cells
Apoptosis
Colon (Anatomy)--Cancer
Tumors--Growth

description: Emergence of tumor resistance to an anti-cancer therapy directed against a putative target raises several questions including: (1) do mutations in the target/pathway confer resistance? (2) Are these mutations pre-existing? (3) What is the relative fitness of cells with/without the mutation? We addressed these questions in patients with metastatic colorectal cancer (mCRC). We conducted an exhaustive review of published data to establish a median doubling time for CRCs and stained a cohort of CRCs to document mitotic indices. We analyzed published data and our own data to calculate rates of growth (g) and regression (d, decay) of tumors in patients with CRC correlating these results with the detection of circulating MT-KRAS DNA. Additionally we estimated mathematically the caloric burden of such tumors using data on mitotic and apoptotic indices. We conclude outgrowth of cells harboring intrinsic or acquired MT-KRAS cannot explain resistance to anti-EGFR (epidermal growth factor receptor) antibodies. Rates of tumor growth with panitumumab are unaffected by presence/absence of MT-KRAS. While MT-KRAS cells may be resistant to anti-EGFR antibodies, WT-KRAS cells also rapidly bypass this blockade suggesting inherent resistance mechanisms are responsible and a neutral evolution model is most appropriate. Using the above clinical data on tumor doubling times and mitotic and apoptotic indices we estimated the caloric intake required to support tumor growth and suggest it may explain in part cancer-associated cachexia.
Alien others : speculative hybrids in imaginary worlds
Creators: name: Martini, Chandra
Publisher: name: University of British Columbia
Year: 2012

description: Hybridity plays a principal role in both J. R. R. Tolkien’s The Silmarillion and Octavia E. Butler’s Xenogenesis trilogy, crystallizing in the treatment of the origin of species. Through these texts I investigate how the generic condition of speculative fiction (SF), in its claims to unreality, opens up an imaginative space in which to excavate hybridity as a site of tension between the concepts of race and species. I draw on the theoretical constructs of hybridity and posthumanism, particularly as formulated by Robert Young in the first case and Cary Wolfe in the second, to argue that these concepts are fundamentally interdependent in post-Enlightenment Western humanism. Both Young and Wolfe show how a tradition of Western humanism has enabled, justified and managed the oppression of both animal and racial Others by casting them as subhuman. Tolkien’s and Butler’s representations of hybridity are haunted by historical manifestations of this logic; Tolkien’s Half Elves are informed by the threat of the Nazi programme of racial purification, and Butler’s human-alien hybrids recall a legacy of slavery and a contemporary discourse of genetics. By blurring the boundary between race and species, they expose the fact that race and species are always already mutually constituting. Drawing on Butler’s and Tolkien’s texts, I argue the importance of integrating an analysis of race into the efforts begun in posthumanist animal studies to build a more honest and ethical way of thinking through the relationship between our species and others.
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis
Creators: name: Garg, Ankur
name: Bansal, Mukesh
name: Gotoh, Noriko
name: Feng, Gen-Sheng
name: Zhong, Jian
name: Wang, Fen
name: Kariminejad, Ariana
name: Brooks, Steven E.
name: Zhang, Xin
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Neural crest
subject: Lacrimal apparatus
subject: Genetics
subject: FOS: Biological sciences
subject: Ophthalmology

description: The sequential use of signaling pathways is essential for the guidance of pluripotent progenitors into diverse cell fates. Here, we show that Shp2 exclusively mediates FGF but not PDGF signaling in the neural crest to control lacrimal gland development. In addition to preventing p53-independent apoptosis and promoting the migration of Sox10-expressing neural crests, Shp2 is also required for expression of the homeodomain transcription factor Alx4, which directly controls Fgf10 expression in the periocular mesenchyme that is necessary for lacrimal gland induction. We show that Alx4 binds an Fgf10 intronic element conserved in terrestrial but not aquatic animals, underlying the evolutionary emergence of the lacrimal gland system in response to an airy environment. Inactivation of ALX4/Alx4 causes lacrimal gland aplasia in both human and mouse. These results reveal a key role of Alx4 in mediating FGF-Shp2-FGF signaling in the neural crest for lacrimal gland development.
Benefit of early discharge among patients with low-risk pulmonary embolism
Creators: name: Wang, Li
name: Baser, Onur
name: Wells, Phil
name: Peacock, W. Frank
name: Coleman, Craig I.
name: Fermann, Gregory J.
name: Schein, Jeff
name: Crivera, Concetta
Publisher: name: Columbia University
Year: 2017
Subjects: Pulmonary embolism
Hospital utilization--Length of stay
Emergency medicine

description: Clinical guidelines recommend early discharge of patients with low-risk pulmonary embolism (LRPE). This study measured the overall impact of early discharge of LRPE patients on clinical outcomes and costs in the Veterans Health Administration population. Adult patients with ≥1 inpatient diagnosis for pulmonary embolism (PE) (index date) between 10/2011-06/2015, continuous enrollment for ≥12 months pre- and 3 months post-index date were included. PE risk stratification was performed using the simplified Pulmonary Embolism Stratification Index. Propensity score matching (PSM) was used to compare 90-day adverse PE events (APEs) [recurrent venous thromboembolism, major bleed and death], hospital-acquired complications (HACs), healthcare utilization, and costs among short (≤2 days) versus long length of stay (LOS). Net clinical benefit was defined as 1 minus the combined rate of APE and HAC. Among 6,746 PE patients, 95.4% were men, 22.0% were African American, and 1,918 had LRPE. Among LRPE patients, only 688 had a short LOS. After 1:1 PSM, there were no differences in APE, but short LOS had fewer HAC (1.5% vs 13.3%, 95% CI: 3.77–19.94) and bacterial pneumonias (5.9% vs 11.7%, 95% CI: 1.24–3.23), resulting in better net clinical benefit (86.9% vs 78.3%, 95% CI: 0.84–0.96). Among long LOS patients, HACs (52) exceeded APEs (14 recurrent DVT, 5 bleeds). Short LOS incurred lower inpatient ($2,164 vs $5,100, 95% CI: $646.8-$5225.0) and total costs ($9,056 vs $12,544, 95% CI: $636.6-$6337.7). LRPE patients with short LOS had better net clinical outcomes at lower costs than matched LRPE patients with long LOS.
Additional file 3 of A comprehensive medical Spanish curriculum model: the Vida Medical Spanish Curriculum
Creators: name: Chang, Kyle E.
name: Lewis, Jennifer
name: Lopez Vera, Alexandra
Publisher: name: figshare
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3.
Optimal stopping problems for the maximum process with upper and lower caps
Creators: name: Ott, Curdin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: This paper concerns optimal stopping problems driven by the running maximum of a spectrally negative Lévy process $X$. More precisely, we are interested in modifications of the Shepp-Shiryaev optimal stopping problem [Avram, Kyprianou and Pistorius Ann. Appl. Probab. 14 (2004) 215-238; Shepp and Shiryaev Ann. Appl. Probab. 3 (1993) 631-640; Shepp and Shiryaev Theory Probab. Appl. 39 (1993) 103-119]. First, we consider a capped version of the Shepp-Shiryaev optimal stopping problem and provide the solution explicitly in terms of scale functions. In particular, the optimal stopping boundary is characterised by an ordinary differential equation involving scale functions and changes according to the path variation of $X$. Secondly, in the spirit of [Shepp, Shiryaev and Sulem Advances in Finance and Stochastics (2002) 271-284 Springer], we consider a modification of the capped version of the Shepp-Shiryaev optimal stopping problem in the sense that the decision to stop has to be made before the process $X$ falls below a given level.
description: Published in at http://dx.doi.org/10.1214/12-AAP903 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Community assembly of coral reef fishes along the Melanesian biodiversity gradient
Creators: name: Drew, Joshua Adam
name: Amatangelo, Kathryn L.
Publisher: name: Columbia University
Year: 2017
Subjects: Coral reef fishes
Coral reef ecology
Species diversity
Fish communities

description: The Indo-Pacific is home to Earth’s most biodiverse coral reefs. Diversity on these reefs decreases from the Coral Triangle east through the islands of Melanesia. Despite this pattern having been identified during the early 20th century, our knowledge about the interaction between pattern and process remains incomplete. To evaluate the structure of coral reef fish communities across Melanesia, we obtained distributional records for 396 reef fish species in five taxa across seven countries. We used hierarchical clustering, nestedness, and multiple linear regression analyses to evaluate the community structure. We also compiled data on life history traits (pelagic larval duration, body size and schooling behavior) to help elucidate the ecological mechanisms behind community structure. Species richness for these taxa along the gradient was significantly related to longitude but not habitat area. Communities are significantly nested, indicating that species-poor communities are largely composed of subsets of the species found on species rich reefs. These trends are robust across taxonomic groups except for the Pomacentridae, which exhibit an anti-nested pattern, perhaps due to a large number of endemic species. Correlations between life history traits and the number of reefs on which species occurred indicate that dispersal and survival ability contribute to determining community structure. We conclude that distance from the Coral Triangle dominates community structure in reef fish; however, conservation of the most species-rich areas will not be sufficient alone to conserve the vivid splendor of this region.
A universal bound on N-point correlations from inflation
Creators: name: Smith, Kendrick M.
name: LoVerde, Marilena
name: Zaldarriaga, Matias
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Models of inflation in which non-Gaussianity is generated outside the horizon, such as curvaton models, generate distinctive higher-order correlation functions in the CMB and other cosmological observables. Testing for violation of the Suyama-Yamaguchi inequality tauNL >= (6/5 fNL)^2, where fNL and tauNL denote the amplitude of the three-point and four-point functions in certain limits, has been proposed as a way to distinguish qualitative classes of models. This inequality has been proved for a wide range of models, but only weaker versions have been proved in general. In this paper, we give a proof that the Suyama-Yamaguchi inequality is always satisfied. We discuss scenarios in which the inequality may appear to be violated in an experiment such as Planck, and how this apparent violation should be interpreted. We analyze a specific example, the "ungaussiton" model, in which leading-order scaling relations suggest that the Suyama-Yamaguchi inequality is eventually violated, and show that the inequality always holds.
description: reference added, typos corrected, matches PRL published version
The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing
Creators: name: Aik, Wei Shen
name: Lin, Min-Han
name: Tan, Dazhi
name: Tripathy, Ashutosh
name: Marzluff, William F.
name: Dominski, Zbigniew
name: Chou, Chi-Yuan
name: Tong, Liang
Publisher: name: Columbia University
Year: 2017
Subjects: Crosslinking (Polymerization)
Dimers
Crystals--Structure
Biology

description: Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3’-end by a mechanism distinct from cleavage and polyadenylation. They have a 3’ stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and U7 snRNP, respectively. The N-terminal domain (NTD) of Lsm11, a component of U7 snRNP, interacts with FLASH NTD and these two proteins recruit the histone cleavage complex containing the CPSF-73 endonuclease for the cleavage reaction. Here, we determined crystal structures of FLASH NTD and found that it forms a coiled-coil dimer. Using solution light scattering, we characterized the stoichiometry of the FLASH NTD-Lsm11 NTD complex and found that it is a 2:1 heterotrimer, which is supported by observations from analytical ultracentrifugation and crosslinking.
On Measure Transformed Canonical Correlation Analysis
Creators: name: Todros, Koby
name: Hero, Alfred O.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In this paper linear canonical correlation analysis (LCCA) is generalized by applying a structured transform to the joint probability distribution of the considered pair of random vectors, i.e., a transformation of the joint probability measure defined on their joint observation space. This framework, called measure transformed canonical correlation analysis (MTCCA), applies LCCA to the data after transformation of the joint probability measure. We show that judicious choice of the transform leads to a modified canonical correlation analysis, which, in contrast to LCCA, is capable of detecting non-linear relationships between the considered pair of random vectors. Unlike kernel canonical correlation analysis, where the transformation is applied to the random vectors, in MTCCA the transformation is applied to their joint probability distribution. This results in performance advantages and reduced implementation complexity. The proposed approach is illustrated for graphical model selection in simulated data having non-linear dependencies, and for measuring long-term associations between companies traded in the NASDAQ and NYSE stock markets.
Additional file 1 of Telemedical support for prehospital emergency medical service in severe emergencies: an open-label randomised non-inferiority clinical trial
Creators: name: Kowark, Ana
name: Felzen, Marc
name: Ziemann, Sebastian
name: Wied, Stephanie
name: Czaplik, Michael
name: Beckers, Stefan K.
name: Brokmann, Jörg C.
name: Hilgers, Ralf-Dieter
name: Rossaint, Rolf
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Science Policy
classificationCode: 111714
subject: Mental Health
classificationCode: 60506
subject: Virology

description: Additional file 1. Study protocol.
Segre Classes on Smooth Projective Toric Varieties
Creators: name: Moe, Torgunn Karoline
name: Qviller, Nikolay
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We provide a generalization of the algorithm of Eklund-Jost-Peterson for computing Segre classes of closed subschemes of projective k-space. The algorithm is here generalized to computing the Segre classes of closed subschemes of smooth projective toric varieties.
description: 19 pages, 1 figure, added references, corrected typos, minor text replacements