title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð»Ð¸-Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð¾Ð²ÑÑ Ð¼Ð°ÑÑÐ¸Ñ ÑÐ¾ ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾Ð²ÐµÑÑ Ð½Ð¾ÑÑÑÑ Ð´Ð»Ñ ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¼ÐµÐ·ÐµÐ½Ñ Ð¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÑÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Formation of poly-Îµ-caprolactone matrices with a structured surface for a cultivation of mesenchymal stem cells
Creators: name: Ð¡ÐµÑÐµÐ´ÐºÐ¸Ð½Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¿Ð¾Ð»Ð¸--ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½
Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ°
Ð¼ÐµÐ·ÐµÐ½Ñ Ð¸Ð¼Ð°Ð»ÑÐ½ÑÐµ ÑÑÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÐµ ÐºÐ»ÐµÑÐºÐ¸
Ð°ÑÐ³Ð¸Ð½Ð¸Ð½
poly--caprolactone
polymer modification
mesenchymal stem cells
arginine

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð»Ð¸-Îµ-ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½Ð¾Ð²ÑÑ (ÐÐÐ) Ð¼Ð°ÑÑÐ¸Ñ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¿ÑÐ¸ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ, Ð½Ð° Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð°ÑÐ³Ð¸Ð½Ð¸Ð½Ð¾Ð¼ Ð¸ ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÐ·ÐµÐ½ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÑÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº (ÐÐ¡Ð). ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: â ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¼Ð°ÑÑÐ¸ÑÑ ÑÐ¾ ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÑÑ; â Ð¾ÑÐµÐ½Ð¸ÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ ÐÐÐ Ð¼Ð°ÑÑÐ¸Ñ Ð½Ð° ÑÐ¾ÑÐ±ÑÐ¸Ñ Ð°ÑÐ³Ð¸Ð½Ð¸Ð½Ð°; â Ð¸Ð·ÑÑÐ¸ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð¼Ð°ÑÑÐ¸Ñ Ð´Ð¾ Ð¸ Ð¿Ð¾ÑÐ»Ðµ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸; â Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÑ Ð°Ð´Ð³ÐµÐ·Ð¸Ñ Ð¸ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ñ ÐÐ¡Ð Ð½Ð° Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÐÐÐ Ð¼Ð°ÑÑÐ¸ÑÐ°Ñ. ÐÑÐ»Ð¾ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¾ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ðµ Ð¼Ð°ÑÑÐ¸Ñ ÑÐ¾ ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÑÑ Ð¸ Ð´Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ ÐµÐµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð°ÑÐ³Ð¸Ð½Ð¸Ð½Ð¾Ð²ÑÑ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ Ð¼Ð°ÑÑÐ¸Ñ. ÐÑÐ»Ð¾ ÑÐ°ÐºÐ¶Ðµ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ÑÑÑÑÑÐ²Ð¸Ðµ Ð°ÑÐ³Ð¸Ð½Ð¸Ð½Ð° Ð½Ð° Ð¼Ð°ÑÑÐ¸ÑÐµ ÑÐ»ÑÑÑÐ°ÐµÑ Ð°Ð´Ð³ÐµÐ·Ð¸Ñ Ð¸ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ñ ÐÐ¡Ð. Ð ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÑ Ð±ÐµÐ· Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¹ Ð½Ðµ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ ÑÑÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð½Ð° ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÐÐ¡Ð. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð² Ð³ÑÑÐ¿Ð¿Ðµ ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð¹ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ð¸ Ð½Ð° Ð±Ð°Ð·Ðµ Ð¦ÐµÐ½ÑÑÐ° ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÐÐÐ¦ Ð ÐÐ. ÐÑÐ¸ Ð½Ð°Ð¿Ð¸ÑÐ°Ð½Ð¸Ð¸ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð·Ð¾ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð±Ð°Ð·Ñ Ð´Ð°Ð½Ð½ÑÑ: Elsevier, ResearchGate Ð¸ Pubmed. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Microsoft Excel, GraphPad Prism 9 Ð¸ Image J.
description: This work is devoted to the study of the effect of arginine modification of poly-Îµ-caprolactone (PCL) matrices obtained under various conditions of formation on the cultivation of mesenchymal stem cells. Tasks that were solved during the study: â to develop matrices with a structured surface; â to evaluate the effect of the surface structure of the PCL matrices on a sorption of arginine; â to study properties of the matrices before and after the modification; â to analyze the adhesion and proliferation of MSCs on the modified PCL matrices. The preparation of matrices with a structured surface was described and its effect on the arginine modification and characteristics of the matrices was proved. The presence of arginine on the matrix has been shown to improve MSCs adhesion and proliferation. A structured surface without modifications does not significantly affect the cultivation of MSCs. The work was performed in the tissue engineering group at the Center for Cell Technologies of the INC of the Russian Academy of Sciences. When writing the literary review, the following databases were used: Elsevier, ResearchGate and Pubmed. Statistical processing of experimental data was carried out using the Microsoft Excel software package, GraphPad Prism 9 and Image J.