cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway
Creators: name: Zhang, Yixin
name: Zeng, Youcheng
name: Huang, Ming
name: Cao, Guodong
name: Lin, Liang
name: Wang, Xiaoyue
name: Cheng, Qinghong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Sepsis is a systemic inflammatory response syndrome caused by infection, which causes renal dysfunction known as sepsis-associated acute kidney injury (S-AKI). Ferroptosis is a form of lipid peroxidation dependent on iron and reactive oxygen species that differs from other forms of programmed cell death at the morphological and biochemical levels. Andrographolide (AG), a natural diterpenoid lactone compound extracted from Andrographis paniculata, has been shown to have therapeutic effects in kidney disease. In this study, we investigated the novel mechanism by which AG attenuates septic acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells (HK-2) through the Nrf2/FSP1 pathway. Cecum ligation and puncture (CLP)-induced septic rats and lipopolysaccharide (LPS)-induced HK-2 cells were used for in vivo and in vitro experiments. Firstly, in septic rats and HK-2 cells, AG effectively decreased the levels of kidney injury indicators, including blood creatinine, urea nitrogen, and markers of kidney injury such as neutrophil gelatinase-associated lipid transport protein and kidney injury molecule-1 (KIM-1). In addition, AG prevented ferroptotosis, by avoiding the accumulation of iron and lipid peroxidation, and an increase in SLC7A11 and GPX4 in AG-treated HK-2 cells. Furthermore, AG attenuated mitochondrial damage, including mitochondrial swelling, outer membrane rupture, and a reduction in mitochondrial cristae in LPS-treated HK-2 cells. Ferrostatin-1 (Fer-1), a ferroptosis inhibitor, significantly inhibited LPS-induced ferroptosis in HK-2 cells. Importantly, our results confirm that Nrf2/FSP1 is an important pathway for ferroptosis resistance. Nrf2 siRNA hindered the effect of AG in attenuating acute kidney injury and inhibiting ferroptosis. These findings demonstrate that Nrf2/FSP1-mediated HK-2 ferroptosis is associated with AG, alleviates septic acute kidney injury, and indicates a novel avenue for therapeutic interventions in the treatment of acute kidney injury in sepsis.
The reciprocal nature of the relationship between parenting and adolescent problem behaviors
Creators: name: Arim, Rubab Gozde
Publisher: name: University of British Columbia
Year: 2009

description: This research is comprised of three separate studies which utilized adolescent self-report data from the Canadian National Longitudinal Survey of Children and Youth (NLSCY). The first study evaluated the factor structure and the equality of measurement properties of three parenting behavior scales (i.e., Parental Nurturance, Parental Rejection, and Parental Monitoring) over a four-year period and found that the factor structure of the NLSCY parenting behavior scales did not show a good fit across three age groups. Revised models for Parental Nurturance and Monitoring were tested and confirmed, however, these models exhibited only configural invariance over time. The second study examined the factor structure and the equality of measurement properties of three problem behavior scales (i.e., Indirect Aggression, Direct Aggression, and Property Offence) across gender and three adolescent age groups (10-11, 12-13, and 14-15 years). This study found support for the structure of the three problem behavior scales, but failed to provide evidence for measurement invariance across groups. All three scales achieved configural invariance across gender and age groups. In addition, the Indirect Aggression scale achieved loading invariance across gender and for the 12 versus 14 year-olds; whereas the Direct Aggression scale exhibited loading invariance for only the 10 versus 12 year-olds. The third study investigated the reciprocal relationship between parental nurturance and adolescent aggression (both indirect and direct aggression) over a four-year period and found that, for girls, parental nurturance at age 10 was associated with both indirect and direct aggression at age 12. For boys, parental nurturance at age 12 was associated with both aggressive behaviors at age 14. The implications of these results for the measurement of parenting and problem behaviors and for the examination of the reciprocal influences in transactional models are discussed, with suggestions for future research.
Fractional solubility of iron in mineral dust aerosols over coastal Namibia: a link to marine biogenic emissions?
Creators: name: Desboeufs, Karine
name: Formenti, Paola
name: Torres-Sánchez, Raquel
name: Schepanski, Kerstin
name: Chaboureau, Jean-Pierre
name: Andersen, Hendrik
name: Cermak, Jan
name: Feuerstein, Stefanie
name: Laurent, Benoit
name: Klopper, Danitza
name: Namwoonde, Andreas
name: Cazaunau, Mathieu
name: Chevaillier, Servanne
name: Feron, Anaïs
name: Mirande-Bret, Cécile
name: Triquet, Sylvain
name: Piketh, Stuart J.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: fractional solubility of iron
subject: mineral dust aerosols
subject: coastal Namibia
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: This paper presents the first investigation of the solubility of iron in mineral dust aerosols collected at the Henties Bay Aerosol Observatory (HBAO), in Namibia, from April to December 2017. During the study period, 10 intense dust events occurred. Elemental iron reached peak concentrations as high as 1.5 µg m−3, significantly higher than background levels. These events are attributed to wind erosion of natural soils from the surrounding gravel plains of the Namib desert. The composition of the sampled dust is found to be overall similar to that of aerosols from northern Africa but is characterized by persistent and high concentrations of fluorine which are attributed to local fugitive dust. The fractional solubility of Fe (%SFe) for both the identified dust episodes and background conditions ranged between 1.3 % and 20 % and averaged at 7.9 % (±4.1 %) and 6.8 (±3.3 %), respectively. Even under background conditions, the %SFe was correlated with that of Al and Si. The solubility was lower between June and August and increased from September onwards during the austral spring. The relation to measured concentrations of particulate MSA (methane sulfonic acid), solar irradiance, and wind speed suggests a possible two-way interaction whereby marine biogenic emissions from the coastal Benguela upwelling to the atmosphere would increase the solubility of iron-bearing dust according to the photo-reduction processes. This first investigation points to the western coast of southern Africa as a complex environment with multiple processes and active exchanges between the atmosphere and the Atlantic Ocean, requiring further research.
Additional file 4: of A bioenergetic assessment of photosynthetic growth of Synechocystis sp. PCC 6803 in continuous cultures
Creators: name: Touloupakis, Eleftherios
name: Cicchi, Bernardo
name: Torzillo, Giuseppe
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Plant Biology

description: Table S3. Comparison of amino acid composition of Synechocystis cultured at three different dilution rates.
Interannual variations in the seasonal cycle of extreme precipitation in Germany and the response to climate change
Creators: name: Peter, Madlen
name: Rust, Henning W.
name: Ulbrich, Uwe
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: extreme precipitation
subject: interannual variations
subject: Germany
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Annual maxima of daily precipitation sums can be typically described well with a stationary generalized extreme value (GEV) distribution. In many regions of the world, such a description does also work well for monthly maxima for a given month of the year. However, the description of seasonal and interannual variations requires the use of non-stationary models. Therefore, in this paper we propose a non-stationary modeling strategy applied to long time series from rain gauges in Germany. Seasonal variations in the GEV parameters are modeled with a series of harmonic functions and interannual variations with higher-order orthogonal polynomials. By including interactions between the terms, we allow for the seasonal cycle to change with time. Frequently, the shape parameter ξ of the GEV is estimated as a constant value also in otherwise instationary models. Here, we allow for seasonal–interannual variations and find that this is beneficial. A suitable model for each time series is selected with a stepwise forward regression method using the Bayesian information criterion (BIC). A cross-validated verification with the quantile skill score (QSS) and its decomposition reveals a performance gain of seasonally–interannually varying return levels with respect to a model allowing for seasonal variations only. Some evidence can be found that the impact of climate change on extreme precipitation in Germany can be detected, whereas changes are regionally very different. In general, an increase in return levels is more prevalent than a decrease. The median of the extreme precipitation distribution (2-year return level) generally increases during spring and autumn and is shifted to later times in the year; heavy precipitation (100-year return level) rises mainly in summer and occurs earlier in the year.
Exsul alfredoi Barbosa & Couri, 2013, sp. n.
Creators: name: Barbosa, Leandro Silva
name: Couri, Márcia Souto
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Muscidae
Exsul
Exsul alfredoi

description: Exsul alfredoi sp. n.
(Figs. 12–16)
Holotype male, deposited at Auckland Museum.
Type-locality: New Zealand, southwest of South Island.
Diagnosis. Its appearance is very similar to E. tenuis differing as follows: dorsocentrals 4+4; katepisternals 2+3; notopleurals 4. Aedeagal apodema thicker than the others species, paramere end not pointed; sternite 5 rounded; cercal plate slender with upper concavity deeper than others species. Wings similar to E. tenuis.
Male. Body length: 10 mm; wing: 13 mm
General coloration. Similar to previous species.
Head. frontal row with six pairs of setae
Abdomen. Cylindrical.
Terminalia. Hypandrium plate-like. Aedeagus enlarged; distiphallus complex with sclerotized structure and distal membrane short; gonopod developed and paramere subrounded (Fig. 12). Sternite 5 setulose, rounded (Fig. 13). Cercal plate slender with a deep posterior concavity (Fig. 14).
Female. Length: 11 mm, wing: 12 mm
Similar to Exsul tenuis female, except for dorsocentrals 4+4. Wings hyaline. Abdomen elliptic.
Ovipositor. Moderately long, with large tergites with setae on posterior edge. Sternite 6 broad and 7 arrowshape with six setae (Fig. 15–16).
Etymology: The specific name is in honor of first author’s father, Carlos Alfredo Barbosa, present in all aspects of my life.
Material examined. NEW ZEALAND: McKinnon Pass, 29–30.xii.1919, [no collector name] [Holotype 13 (nº 85.708), Paratype 1Ƥ (nº 85711) AMNZ].
Discussion
The disposition of dorsocentrals 4+ 4 in both sexes, the presence of 4 notopleurals and 2+3 katepisternals in males, and the genital structures of the new species are very distinctive from the other species. The three species can be easily separated especially by the dorsocentral setae. The color pattern does not show a significant difference. All three species show an accentuated dimorphism, where the males are more distinguishable than females.
description: Published as part of Barbosa, Leandro Silva & Couri, Márcia Souto, 2013, New species and redescriptions of the New Zealand genus Exsul Hutton (Diptera: Muscidae: Coenosiinae), pp. 382-389 in Zootaxa 3647 (2) on pages 386-389, DOI: 10.11646/zootaxa.3647.2.9, http://zenodo.org/record/223965
Cold stress induces rapid gene-specific changes in the levels of H3K4me3 and H3K27me3 in Arabidopsis thaliana
Creators: name: Faivre, Léa
name: Kinscher, Nathalie-Francesca
name: Kuhlmann, Ana Belén
name: Xu, Xiaocai
name: Kaufmann, Kerstin
name: Schubert, Daniel
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: chromatin
subject: histone methylation
subject: cold stress
subject: polycomb
subject: trithorax
subject: Arabidopsis
subject: 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::580 Pflanzen (Botanik)

description: When exposed to low temperatures, plants undergo a drastic reprogramming of their transcriptome in order to adapt to their new environmental conditions, which primes them for potential freezing temperatures. While the involvement of transcription factors in this process, termed cold acclimation, has been deeply investigated, the potential contribution of chromatin regulation remains largely unclear. A large proportion of cold-inducible genes carries the repressive mark histone 3 lysine 27 trimethylation (H3K27me3), which has been hypothesized as maintaining them in a silenced state in the absence of stress, but which would need to be removed or counteracted upon stress perception. However, the fate of H3K27me3 during cold exposure has not been studied genome-wide. In this study, we offer an epigenome profiling of H3K27me3 and its antagonistic active mark H3K4me3 during short-term cold exposure. Both chromatin marks undergo rapid redistribution upon cold exposure, however, the gene sets undergoing H3K4me3 or H3K27me3 differential methylation are distinct, refuting the simplistic idea that gene activation relies on a switch from an H3K27me3 repressed chromatin to an active form enriched in H3K4me3. Coupling the ChIP-seq experiments with transcriptome profiling reveals that differential histone methylation only weakly correlates with changes in expression. Interestingly, only a subset of cold-regulated genes lose H3K27me3 during their induction, indicating that H3K27me3 is not an obstacle to transcriptional activation. In the H3K27me3 methyltransferase curly leaf (clf) mutant, many cold regulated genes display reduced H3K27me3 levels but their transcriptional activity is not altered prior or during a cold exposure, suggesting that H3K27me3 may serve a more intricate role in the cold response than simply repressing the cold-inducible genes in naïve conditions.
Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells
Creators: name: Ganguly, Upasana
name: Singh, Sukhpal
name: Bir, Aritri
name: Ghosh, Arindam
name: Chakrabarti, Sankha Shubhra
name: Saini, Reena V
name: Saso, Luciano
name: Bisaglia, Marco
name: Chakrabarti, Sasanka
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: Ferroptosis has been characterized as a form of iron-dependent regulated cell death accompanied by an accumulation of reactive oxygen species and lipid oxidation products along with typical morphological alterations in mitochondria. Ferroptosis is activated by diverse triggers and inhibited by ferrostatin-1 and liproxstatin-1, apart from iron chelators and several antioxidants, and the process is implicated in multiple pathological conditions. There are, however, certain ambiguities about ferroptosis, especially regarding the final executioner of cell death subsequent to the accumulation of ROS. This study uses a typical inducer of ferroptosis such as erastin on SH-SY5Y cells, and shows clearly that ferroptotic death of cells is accompanied by the loss of mitochondrial membrane potential and intracellular ATP content along with an accumulation of oxidative stress markers. All these are prevented by ferrostatin-1 and liproxstatin-1. Additionally, cyclosporine A prevents mitochondrial alterations and cell death induced by erastin implying the crucial role of mitochondrial permeability transition pore (mPTP) activation in ferroptotic death. Furthermore, an accumulation of α-synuclein occurs during erastin induced ferroptosis which can be inhibited by ferrostatin-1 and liproxstatin-1. When the knock-down of α-synuclein expression is performed by specific siRNA treatment of SH-SY5Y cells, the mitochondrial impairment and ferroptotic death of the cells induced by erastin are markedly prevented. Thus, α-synuclein through the involvement of mPTP appears to be the key executioner protein of ferroptosis induced by erastin, but it needs to be verified if it is a generalized mechanism of ferroptosis by using other inducers and cell lines.
Additional file 5: Figure S5. of Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone
Creators: name: Walsh, Jennifer
name: W. Shriver
name: Olsen, Brian
name: Kovach, Adrienne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Genomic clines estimated in introgress for A. caudacutus and A. nelsoni. Each plot represents a marker and includes the name of each locus and a P value from the analysis. Solid color lines represent genomic clines for caudacutus homozygote genotypes, dashed lines represent genomic clines for heterozygote genotypes. Shaded areas represent 95Â % confidence intervals. (PDF 1572Â kb)
Survival of highly related ESBL- and pAmpC- producing Escherichia coli in broiler farms identified before and after cleaning and disinfection using cgMLST
Creators: name: Robé, Caroline
name: Projahn, Michaela
name: Boll, Katrin
name: Blasse, Anja
name: Merle, Roswitha
name: Roesler, Uwe
name: Friese, Anika
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: ESBL
subject: pAmpC
subject: Escherichia coli
subject: Broiler chicken
subject: Cleaning and disinfection
subject: Intervention
subject: Whole genome sequencing
subject: Transmission
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Background Broiler chickens are frequently colonized with Extended-Spectrum Beta-Lactamase- (ESBL-) and plasmid mediated AmpC Beta-Lactamase- (pAmpC-) producing Enterobacterales, and we are confronted with the potential spread of these resistant bacteria in the food chain, in the environment, and to humans. Research focused on identifying of transmission routes and investigating potential intervention measures against ESBL- and pAmpC- producing bacteria in the broiler production chain. However, few data are available on the effects of cleaning and disinfection (C&D) procedures in broiler stables on ESBL- and pAmpC- producing bacteria. Results We systematically investigated five broiler stables before and after C&D and identified potential ESBL- and pAmpC- colonization sites after C&D in the broiler stables, including the anteroom and the nearby surrounding environment of the broiler stables. Phenotypically resistant E. coli isolates grown on MacConkey agar with cefotaxime were further analyzed for their beta-lactam resistance genes and phylogenetic groups, as well as the relation of isolates from the investigated stables before and after C&D by whole genome sequencing. Survival of ESBL- and pAmpC- producing E. coli is highly likely at sites where C&D was not performed or where insufficient cleaning was performed prior to disinfection. For the first time, we showed highly related ESBL-/pAmpC- producing E. coli isolates detected before and after C&D in four of five broiler stables examined with cgMLST. Survival of resistant isolates in investigated broiler stables as well as transmission of resistant isolates from broiler stables to the anteroom and surrounding environment and between broiler farms was shown. In addition, enterococci (frequently utilized to detect fecal contamination and for C&D control) can be used as an indicator bacterium for the detection of ESBL-/pAmpC- E. coli after C&D. Conclusion We conclude that C&D can reduce ESBL-/pAmpC- producing E. coli in conventional broiler stables, but complete ESBL- and pAmpC- elimination does not seem to be possible in practice as several factors influence the C&D outcome (e.g. broiler stable condition, ESBL-/pAmpC- status prior to C&D, C&D procedures used, and biosecurity measures on the farm). A multifactorial approach, combining various hygiene- and management measures, is needed to reduce ESBL-/pAmpC- E. coli in broiler farms.
Additional file 1 of Previously unidentified duplicate registrations of clinical trials: an exploratory analysis of registry data worldwide
Creators: name: Valkenhoef, Gert Van
name: Loane, Russell
name: Zarin, Deborah
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Similarity scoring method. A PDF document containing the mathematical details of our similarity scoring method. (PDF 125 kb)
Computationally Designed Epitope-Mediated Imprinted Polymers versus Conventional Epitope Imprints for the Detection of Human Adenovirus in Water and Human Serum Samples
Creators: name: Sehit, Ekin
name: Yao, Guiyang
name: Battocchio, Giovanni
name: Radfar, Rahil
name: Trimpert, Jakob
name: Mroginski, Maria A.
name: Süssmuth, Roderich
name: Altintas, Zeynep
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: virus detection
subject: epitope imprinting
subject: QCM sensor
subject: molecular dynamics
subject: in silico-designed epitope-mediatedadenovirus receptors
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Detection of pathogenic viruses for point-of-care applications has attracted great attention since the COVID-19 pandemic. Current virus diagnostic tools are laborious and expensive, while requiring medically trained staff. Although user-friendly and cost-effective biosensors are utilized for virus detection, many of them rely on recognition elements that suffer major drawbacks. Herein, computationally designed epitope-imprinted polymers (eIPs) are conjugated with a portable piezoelectric sensing platform to establish a sensitive and robust biosensor for the human pathogenic adenovirus (HAdV). The template epitope is selected from the knob part of the HAdV capsid, ensuring surface accessibility. Computational simulations are performed to evaluate the conformational stability of the selected epitope. Further, molecular dynamics simulations are executed to investigate the interactions between the epitope and the different functional monomers for the smart design of eIPs. The HAdV epitope is imprinted via the solid-phase synthesis method to produce eIPs using in silico-selected ingredients. The synthetic receptors show a remarkable detection sensitivity (LOD: 102 pfu mL–1) and affinity (dissociation constant (Kd): 6.48 × 10–12 M) for HAdV. Moreover, the computational eIPs lead to around twofold improved binding behavior than the eIPs synthesized with a well-established conventional recipe. The proposed computational strategy holds enormous potential for the intelligent design of ultrasensitive imprinted polymer binders.
Additional file 12: of Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Creators: name: Slieker, Roderick
name: Iterson, Maarten Van
name: RenĂŠ Luijk
name: Beekman, Marian
name: Zhernakova, Daria
name: Moed, Matthijs
name: Hailiang Mei
name: Galen, Michiel Van
name: Deelen, Patrick
name: Bonder, Marc
name: Zhernakova, Alexandra
name: AndrĂŠ Uitterlinden
name: Tigchelaar, Ettje
name: Stehouwer, Coen
name: Schalkwijk, Casper
name: Kallen, Carla Van Der
name: Hofman, Albert
name: Heemst, Diana Van
name: Eco De Geus
name: Dongen, Jenny Van
name: Deelen, Joris
name: Berg, Leonard Van Den
name: Meurs, Joyce Van
name: Jansen, Rick
name: Hoen, Peter
name: Franke, Lude
name: Wijmenga, Cisca
name: Veldink, Jan
name: Swertz, Morris
name: Greevenbroek, Marleen Van
name: Duijn, Cornelia Van
name: Dorret Boomsma
name: P. Slagboom
name: Heijmans, Bastiaan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Description of external datasets used. (PDF 79 kb)
Additional file 2: of A bioenergetic assessment of photosynthetic growth of Synechocystis sp. PCC 6803 in continuous cultures
Creators: name: Touloupakis, Eleftherios
name: Cicchi, Bernardo
name: Torzillo, Giuseppe
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Plant Biology

description: Table S1. The M0 (initial slope at the beginning of the variable fluorescence), VJ (the variable fluorescence at phase J), ΦE0 (the quantum yield of electron transport), Ψ0 (the efficiency with which a trapped exciton can move an electron further than Q A - into the electron transport chain) and the parameter Sm of Synechocystis in a continuous culture. Values are mean ± standard deviations calculated over the steady state for each dilution rate.
Additional file 7: Table S2. of Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone
Creators: name: Walsh, Jennifer
name: W. Shriver
name: Olsen, Brian
name: Kovach, Adrienne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Restriction Fragment Length Polymorphism (RFLP) assay information for ND2, SLC30A-5, and RAG-1. Table includes the restriction enzyme used for each assay and the approximate sizes of bands produced for each species. Conditions for the restriction digests followed manufacturer protocols. (PDF 71Â kb)
Daochia Wei, Zhang & Webb 2006
Creators: name: Fang, Yongqin
name: Webb, Mick
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Daochia

description: Daochia Wei, Zhang & Webb, 2006
Daochia Wei, Zhang & Webb, 2006: 2062.
Type species: Daochia reticulata Wei, Zhang & Webb, 2006
Diagnosis. This genus is similar to Stegelytra and Honguchia in having reticulate forewing venation and lateral frontal sutures extending to corresponding ocellus, but differs from Stegelytra by: (i) forewing apex truncate; (ii) the anteclypeus broad and convex with latero-apical areas depressed, lora very narrow; (iii) pronotum with lateral carina straight and the posterior margin sinuate; (iv) scutellum without median or posterolateral ridge or keel; (v) valve fused with the subgenital plate; (vi) paramere very elongate and by the apically fimbriolate aedeagus. And it also differs from Honguchia by: (i) the lateral margin of the postclypeus more strongly convex, apical veins of the forewing modified but not reticulate; (ii) the unusual triangular shaped basal lobe of the subgenital plate projecting into the pygofer; (iii) the styles much longer.
description: Published as part of Fang, Yongqin, Webb, Mick & Xing, Jichun, 2020, An unusual new leafhopper species of Daochia Wei, Zhang & Webb, 2006 (Hemiptera: Cicadellidae: Deltocephalinae: Stegelytrini) described from China, pp. 378-386 in Zootaxa 4758 (2) on page 381, DOI: 10.11646/zootaxa.4758.2.11, http://zenodo.org/record/3734385
Fear of Falling Carries Over into Overprotection in Old Age: A Cross-Lagged Panel Analysis
Creators: name: Steckhan, Greta M.
name: Fleig, Lena
name: Wurm, Susanne
name: Wolff, Julia K.
name: Schwarzer, Ralf
name: Warner, Lisa M.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: fear of falling
subject: overprotection
subject: social support
subject: loss of independence
subject: older adults
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Fear of falling might result in overprotection by one's social environment. In turn, feeling dependent could increase fear of falling. However, the association between fear of falling and perceived overprotection and its temporal order is unknown. This longitudinal study explores this potential mutual longitudinal association. This study presents secondary analyses from a larger trial. We tested the association between fear of falling and perceived overprotection in a cross-lagged path model controlled for falls, health-related quality of life, age, gender, and trial condition. N = 310 participants (M = 70 years, range: 64–92) completed self-reports at Time 1, 7 (Time 2), and 11 weeks (Time 3) after baseline assessment. We found a positive association from fear of falling to perceived overprotection (β = .12, 95% CI[0.02, 0.21], p = .02; β = .10; [0.01, 0.18], p = .03). The reversed cross-lagged paths were not significant. Findings suggest higher fear of falling translates into perceived overprotection, which may in turn increase loss of independence in old age.
MOESM1 of A systems analysis of biodiesel production from wheat straw using oleaginous yeast: process design, mass and energy balances
Creators: name: Karlsson, Hanna
name: Ahlgren, Serina
name: Sandgren, Mats
name: Passoth, Volkmar
name: Wallberg, Ola
name: Per-Anders Hansson
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 1: Table S1. Energy demand for unit processes.
Isolation and propagation of an Egyptian Theileria annulata infected cell line and evaluation of its use as a vaccine to protect cattle against field challenge
Creators: name: AL-Hosary, Amira
name: Radwan, Ahmed M.
name: Ahmed, Laila S.
name: Abdelghaffar, Sary Kh.
name: Fischer, Susanne
name: Nijhof, Ard M.
name: Clausen, Peter-Henning
name: Ahmed, Jabbar S.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Theileria annulata
subject: Cell line
subject: Cattle
subject: Vaccine
subject: Egypt
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Tropical theileriosis is an important protozoan tick-borne disease in cattle. Vaccination using attenuated schizont-infected cell lines is one of the methods used for controlling the disease. This study describes the production of attenuated schizont-infected cell lines from Egypt and an evaluation of its use as a vaccine to protect calves against clinical disease upon field challenge. Two groups of exotic and crossbred male calves were divided into vaccinated and control groups. The vaccinated groups were inoculated with 4 ml (1 × 106 cells/ml) of the attenuated cell line. Three weeks after vaccination, calves of both groups were transported to the New Valley Governorate (Egyptian oasis) where they were kept under field conditions and exposed to the natural Theileria annulata challenge. All animals in the control group showed severe clinical signs and died despite treatment with buparvaquone, which was administered after two days of persistent fever due to a severe drop in packed cell volume (PCV). Animals in the vaccinated group became seropositive without developing severe clinical signs other than transient fever. Post-mortem examinations revealed enlarged and fragile lymph nodes, spleen, and liver with necrosis and hemorrhages. These findings indicate that the Egyptian attenuated cell line was successful in protecting both exotic and crossbred animals against tropical theileriosis under field conditions.
Additional file 11: of Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Creators: name: Slieker, Roderick
name: Iterson, Maarten Van
name: RenĂŠ Luijk
name: Beekman, Marian
name: Zhernakova, Daria
name: Moed, Matthijs
name: Hailiang Mei
name: Galen, Michiel Van
name: Deelen, Patrick
name: Bonder, Marc
name: Zhernakova, Alexandra
name: AndrĂŠ Uitterlinden
name: Tigchelaar, Ettje
name: Stehouwer, Coen
name: Schalkwijk, Casper
name: Kallen, Carla Van Der
name: Hofman, Albert
name: Heemst, Diana Van
name: Eco De Geus
name: Dongen, Jenny Van
name: Deelen, Joris
name: Berg, Leonard Van Den
name: Meurs, Joyce Van
name: Jansen, Rick
name: Hoen, Peter
name: Franke, Lude
name: Wijmenga, Cisca
name: Veldink, Jan
name: Swertz, Morris
name: Greevenbroek, Marleen Van
name: Duijn, Cornelia Van
name: Dorret Boomsma
name: P. Slagboom
name: Heijmans, Bastiaan
Publisher: name: Figshare
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: BIOS Consortium (Biobank-based Integrative Omics Study). (PDF 68 kb)
Daochia Wei, Zhang & Webb, 2006: 2062
Creators: name: Fang, Yongqin
name: Webb, Mick
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Daochia

description: Key to species of Daochia from China
1. Aedeagus with long preatrium and pair of elongate process arising from its base (Figs. 12,13; Wei et al., 2006: Figs 30, 31).. ................................................................................................... 2
- Aedeagus not as above (Wei et al, 2006: Figs 25, 26, 36, 37)................................................... 3
2. Aedeagus shaft with pair of papilla-like processes apically on ventral surface (Figs. 12, 13)........... D. fenstrata sp. nov.
- Aedeagus shaft with one pair of short and one pair of long lateral appendages basally (Wei et al., 2006: Figs 30,31)............................................................................................. D. longshengensis
3. Aedeagus with anterior processes short and posterior processes long (Wei et al., 2006: Figs 25, 26............ D.reticulata
- Aedeagus broadly U-shaped with single pair of sub-basal processes (Wei et al., 2006: Figs 36,37).............. D.bicornis
description: Published as part of Fang, Yongqin, Webb, Mick & Xing, Jichun, 2020, An unusual new leafhopper species of Daochia Wei, Zhang & Webb, 2006 (Hemiptera: Cicadellidae: Deltocephalinae: Stegelytrini) described from China, pp. 378-386 in Zootaxa 4758 (2) on page 381, DOI: 10.11646/zootaxa.4758.2.11, http://zenodo.org/record/3734385
The potential of arbuscular mycorrhizal fungi to enhance metallic micronutrient uptake and mitigate food contamination in agriculture: prospects and challenges
Creators: name: Moreno Jiménez, Eduardo
name: Ferrol, Nuria
name: Corradi, Nicolas
name: Peñalosa, Jesús M.
name: Rillig, Matthias C.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: agriculture
subject: arbuscular mycorrhizal fungi
subject: biofortification
subject: contamination
subject: metalloids
subject: metals
subject: micronutrients
subject: mitigation
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Optimizing agroecosystems and crops for micronutrient uptake while reducing issues with inorganic contaminants (metal(loid)s) is a challenging task. One promising approach is to use arbuscular mycorrhizal fungi (AMF) and investigate the physiological, molecular and epigenetic changes that occur in their presence and that lead to changes in plant metal(loid) concentration (biofortification of micronutrients or mitigation of contaminants). Moreover, it is important to understand these mechanisms in the context of the soil microbiome, particularly those interactions of AMF with other soil microbes that can further shape crop nutrition. To address these challenges, a two-pronged approach is recommended: exploring molecular mechanisms and investigating microbiome management and engineering. Combining both approaches can lead to benefits in human health by balancing nutrition and contamination caused by metal(loid)s in the agro-ecosystem.
Concerted transformation of a hyper-paused transcription complex and its reinforcing protein
Creators: name: Zuber, Philipp K.
name: Said, Nelly
name: Hilal, Tarek
name: Wang, Bing
name: Loll, Bernhard
name: González-Higueras, Jorge
name: Ramírez-Sarmiento, César A.
name: Belogurov, Georgiy A.
name: Artsimovitch, Irina
name: Wahl, Markus C.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Cryoelectron microscopy
subject: Transcriptional regulatory elements
subject: RfaH
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the RNAP-binding site. Upon recruitment to RNAP paused at an ops site, KOW is released and refolds into a β-barrel, which binds the ribosome. Here, we report structures of ops-paused transcription elongation complexes alone and bound to the autoinhibited and activated RfaH, which reveal swiveled, pre-translocated pause states stabilized by an ops hairpin in the non-template DNA. Autoinhibited RfaH binds and twists the ops hairpin, expanding the RNA:DNA hybrid to 11 base pairs and triggering the KOW release. Once activated, RfaH hyper-stabilizes the pause, which thus requires anti-backtracking factors for escape. Our results suggest that the entire RfaH cycle is solely determined by the ops and RfaH sequences and provide insights into mechanisms of recruitment and metamorphosis of NusG homologs across all life.
Tránsito
Creators: name: Eduardo, Manet
name: Manet, Eduardo
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Cinéma
''Tránsito''

description: Encart promotionnel pour le film ''Tránsito'' réalisé par Eduardo Manet, présenté par l’Institut Cubain des Arts et de l'Industrie Cinématographique (ICAIC). Les acteur principaux sont  : José Antonio Rodríguez, René de la Cruz, Carlos Ruíz de la Tejera, Asenneh Rodríguez, Ofelia González et Omar Valdés.
description: Anuncio publicitario de la película “Tránsito” dirigida por Eduardo Manet, presentado por el Instituto Cubano de las Artes y la Industria Cinematográfica (ICAIC). Los actores principales son: José Antonio Rodríguez, René de la Cruz, Carlos Ruíz de la Tejera, Asenneh Rodríguez, Ofelia González y Omar Valdés.
description: Notes : Le nom d’Eduardo Manet est entouré au stylo noir sur l’encart.
description: Titre de la publication : El Mundo
description: Périodicité : Quotidien.
description: Source: EM-E1-1964-10-27
description: Source: Localisation de la ressource : Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Additional file 1: Figure S1. of Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone
Creators: name: Walsh, Jennifer
name: W. Shriver
name: Olsen, Brian
name: Kovach, Adrienne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Selection tests for 24 genetic markers for A. caudacutus and A. nelsoni populations. F ST is plotted as a function of heterozygosity. Markers located in the gray area are within neutral expectation, markers in the red area are candidates for positive selection, and markers in the yellow section are candidates for balancing selection. (PDF 305Â kb)
Additional file 9: File S4. of Global transcriptional analysis suggests Lasiodiplodia theobromae pathogenicity factors involved in modulation of grapevine defensive response
Creators: name: Paolinelli-Alfonso, Marcos
name: Villalobos-Escobedo, José
name: Rolshausen, Philippe
name: Herrera-Estrella, Alfredo
name: Galindo-Sánchez, Clara
name: López-Hernández, José
name: Hernandez-Martinez, Rufina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Statistical support of data distribution for differential gene expression quantification (PDF 620 kb)
Additional file 4: Figure S4. of Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone
Creators: name: Walsh, Jennifer
name: W. Shriver
name: Olsen, Brian
name: Kovach, Adrienne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Plot of introgression patterns for 29 markers (24 microsatellites, 1 nuclear gene, 2 mitochondrial genes, and 2 z-linked genes). Each column represents a marker and each row represents an individual (allopatric individuals are not included). Colors correspond to parental alleles: 2 nelsoni alleles (white), 2 caudacutus alleles (black), and 1 allele from each parental population (grey). (PDF 74Â kb)
Additional file 6: of Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
Creators: name: Staley, Lyndsay
name: Ebbert, Mark
name: Bunker, Daniel
name: Bailey, Matthew
name: Ridge, Perry
name: Goate, Alison
name: Kauwe, John
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: File include the command to run METAL software. (DOCX 29Â kb)
Daochia superba Fang & Webb & Xing 2020, comb. nov.
Creators: name: Fang, Yongqin
name: Webb, Mick
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Daochia
Daochia superba

description: Daochia superba (Wei & Webb, 2010) comb. nov.
Honguchia superba Wei & Webb, 2010: 29, figs 1D, 4.
Remarks. In the absence of males this species is tentatively placed in Daochia. Although much larger in size than other congeners and having characteristically shaped second valvulae, D. superba has all the external diagnostic features of Daochia. It was originally placed in Honguchia Wei & Webb, 2010, a genus which is very similar but differs in having the lateral margin of the postclypeus more strongly convex, apical veins of the forewing modified but not reticulate (as in Daochia) and in the male genitalia by the much shorter styles.
description: Published as part of Fang, Yongqin, Webb, Mick & Xing, Jichun, 2020, An unusual new leafhopper species of Daochia Wei, Zhang & Webb, 2006 (Hemiptera: Cicadellidae: Deltocephalinae: Stegelytrini) described from China, pp. 378-386 in Zootaxa 4758 (2) on page 385, DOI: 10.11646/zootaxa.4758.2.11, http://zenodo.org/record/3734385
Additional file 5: of Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
Creators: name: Staley, Lyndsay
name: Ebbert, Mark
name: Bunker, Daniel
name: Bailey, Matthew
name: Ridge, Perry
name: Goate, Alison
name: Kauwe, John
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: File include the contents of METAL meta analysis script. (DOCX 44Â kb)
Additional file 1: Table S1. of A mortality prediction rule for non-elderly patients with community-acquired pneumonia
Creators: name: Tashiro, Masato
name: Kiyohide Fushimi
name: Takazono, Takahiro
name: Kurihara, Shintaro
name: Miyazaki, Taiga
name: Tsukamoto, Misuzu
name: Yanagihara, Katsunori
name: Mukae, Hiroshi
name: Tashiro, Takayoshi
name: Kohno, Shigeru
name: Izumikawa, Koichi
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Definition of scores for each item of the Barthel index used in this study. (DOCX 49.2kb)
Additional file 1: of Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres
Creators: name: Jo, Helen
name: Corte, Tamera
name: Yuben Moodley
name: Kovi Levin
name: Westall, Glen
name: Hopkins, Peter
name: Chambers, Daniel
name: Glaspole, Ian
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Survey Questions. (DOCX 28Â kb)