cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Vom Krieg gegen Terror bis zum Klimawandel: Demokratien und die vier Notstände des 21. Jahrhunderts (bisher)
Creators: name: Greene, Alan
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2022
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
title: Farewell to “Personenwahl”: The Traffic Light Coalition’s Draft for the Electoral Law Reform in Germany
Creators: name: Michl, Fabian
name: Mittrop, Johanna
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
The formation of person’s health: experience of Waldorf school
Creators: name: Ionova, Elena
Publisher: name: figshare
Year: 2013
Subjects: Education

description: In the article is presented the results of comparative researches of the state of health of Waldorf and traditional schools of students, conducted in different countries (Austria, Holland, Germany, Denmark, Russia, Ukraine, Finland, Switzerland, Sweden). It is set that health saving orientation of Waldorf school brings to the considerable successful results of Waldorf education: Waldorf schoolchildren as compared to the students of traditional schools have the best indexes of physical and psychical health, developed cognitive flairs, personality qualities (individual initiativeness, work, independence of decisions, collaboration with people, social mobility). Due to it among the graduating students of Waldorf schools there almost are not unemployed persons (as well as people with asocial behavior). Among the formers Waldorf students there is a high percent of workers of social, educational and medicine sphere; among them there are many also well-known in the west statesmen, financiers, literati, representatives of art and other.
of physical fitness of athletes specializing in combat sambo
Creators: name: Tron, Ruslan
name: Ilyin, V.N.
name: Bitsyura, R.V.
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Confiscation of informative educational tests to assess motor qualities of skilled athletes. The survey was attended by 94 athletes (18 to 30 years). This group of tests includes: running too far on the bridge (second) coups in space (second); perform 100 punches on the punching bag (second), perform 50 kicks on the punching bag (second). It was found that the highest correlation between the result and the qualifications of athletes seen in tests involving the use of wrestling skills (rushing on the bridge and from the place of revolutions). It is shown that in the groups of athletes of medium and heavy weight categories in tests measuring the speed of the application of various attacks on the punching bag have a weak relationship with the level of sportsmanship. The trend is strengthening correlation sports training and exercise, describing the power of athletes of different skills to increase their weight classes.
Scientific knowledge genesis of physical education and sport origin in Ukraine (the investigation were based on the Soviet scientists’ essays)
Creators: name: Taniana Ustinova
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Purpose: Dynamics of development and priority research areas in the field of Soviet science were viewed with the aim of elucidating scientific knowledge genesis of physical education and sport origin in Ukraine. Material: Problematic of the research is revealed in the following periodization: (1939-1965 years) (1966-1990 years). 232 abstracts of essays on physical education and sport origin of the Soviet scientists were analyzed. Results: Nihilism of the Soviet scientists on the physical education and sport origin in the pre-Soviet period of Ukrainian and other ethnic groups who lived on the territories annexed to the USSR in 1939, 1940 and 1945 years is observed. We note the lack of working out of the problem of physical education and sport origin in the Soviet period, within the territory of the USSR. Conclusions: In the Soviet period, the science genesis of physical education and sport origin in Ukraine is characterized as a stage of scientific knowledge formation.
Determining the level of physical development of preschool children
Creators: name: Harina, Dina
Publisher: name: figshare
Year: 2013
Subjects: Education

description: An assessment of the physical development of preschool children. The study involved 74 children - 5 years (34 girls and 40 boys) and 84 pre-school children - 6 years (37 girls and 47 boys). Functional status was determined by measuring the heart rate at rest, lung capacity and sample Rufe. It was established that the children surveyed index indicator corresponds to the level of physical development is above average. Determined that the parameters of the functional state of preschool children meet the age norm. It is established that the determination of physical performance in preschool children 5-year life of the average level detected, and the children of the 6th year of life - satisfactory. It is shown that the average anthropometric measures sex-age groups correspond to the performance of preschool children surveyed, except for girls 6 years.
Correlation between the cadmium, calcium and potassium in the body and indices of cardiovascular system of athletes
Creators: name: Reshetniak, Olga
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Performed a functional examination of the cardiovascular system in 80 students (40 players, 40 students are not involved in sports). Used the method of electrocardiography and computer rheography. The study was conducted in a state of physiological rest during exercise and during the recovery period. The level of chemical elements in the hair was determined by X-ray fluorescence analysis. The element of balance of athletes showed that the elemental balance of athletes in terms of the built environment is more satisfactory than the students. Students have a shortage of essential items. The study features of response of the cardiovascular system to exercise physiological significance of cadmium found in athletes. Character correlations essential elements with indices cardiovascular system conform to their known roles in physiological processes at the cellular level.
Technology of formation of vertical stability bodies of children aged 7 - 10 years of hearing loss
Creators: name: Storozhik, Anna
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Purpose - the development of technology forming the vertical stability of the body of primary school children with impaired hearing. We study the main directions, methods and techniques used in the process of physical education primary school children with impaired hearing. There was a significant backlog of children in this nosology in the development of the equilibrium function. Highlighted the principles of technology forming the vertical stability of hearing children. The technology includes: the goals, objectives, direction and implementation stages, means and methods, criteria for evaluation and the expected effect of the pedagogical impact. The technology will fulfill its function in the event that the child was significantly improved lung function equilibrium amplitude common center of gravity of the body in the main stand on a fixed support with their eyes open; amplitude common center of gravity in the sample Romberg, while retaining posture in the test Bondarevsky. It is noted that the criterion of efficiency of the technology are: improved posture, increase the level of physical fitness, the appearance of confidence in his walk and accuracy in the movements and gestures.
title: Das Konzept der Treuhandschaft für die Erde
Creators: name: Bosselmann, Klaus
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2022
Subjects: subject: Nachhaltigkeit
subject: 340

description: Seit dem ersten Erdgipfel 1972 in Stockholm hat sich ein Völkerrecht entwickelt, das eine generelle Rechtspflicht der Staaten zum Schutz der globalen Umwelt in sich trägt. Bis heute wird diese Verpflichtung aber nur in Ausschnitten wahrgenommen - Luft, Gewässer, Arten, Klima - und in völlig unzureichender Weise. Nach 50 Jahren hat die Ökologiekrise ein Ausmaß angenommen, das die Menschheit insgesamt und mit ihr ein Großteil des Lebens auf der Erde existenziell gefährdet. Um diese katastrophale Fehlentwicklung umzukehren, reicht stärkerer Druck auf Regierungen, so wichtig dies ist, allein nicht aus. Wir alle und insbesondere Staaten müssen sich als Treuhänder der Erde verstehen und danach handeln. Die Treuhandverantwortung für Gemeingüter und Natur ist Teil der vorindustriellen Rechtsgeschichte, wird in indigenen Kulturen nach wie vor gelebt und muss zu einer Verantwortung gegenüber der Erde insgesamt entwickelt werden. Der Vortrag zeigt, wie dies rechtlich und institutionell zu verstehen ist und welche Schritte zu einer Treuhandschaft für die Erde bisher unternommen wurden.
DNA methylation differentiates smoking from vaping and non-combustible tobacco use
Creators: name: Andersen, Allan
name: Reimer, Rachel
name: Dawes, Kelsey
name: Becker, Ashley
name: Hutchens, Natasha
name: Miller, Shelly
name: Dogan, Meesha
name: Hundley, Brandon
name: Mills, James A
name: Long, Jeffrey D
name: Philibert, Robert
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Increasing use of non-combusted forms of nicotine such as e-cigarettes poses important public health questions regarding their specific risks relative to combusted tobacco products such as cigarettes. To fully delineate these risks, improved biomarkers that can distinguish between these forms of nicotine use are needed. Prior work has suggested that methylation status at cg05575921 may serve as a specific biomarker of combusted tobacco smoke exposure. We hypothesized combining this epigenetic biomarker with conventional metabolite assays could classify the type of nicotine product consumption. Therefore, we determined DNA methylation and serum cotinine values in samples from 112 smokers, 35 e-cigarette users, 19 smokeless tobacco users, and 269 controls, and performed mass spectroscopy analyses of urine samples from all nicotine users and 22 verified controls to determine urinary levels of putatively nicotine product-specific substances; propylene glycol, 2-cyanoethylmercapturic acid (CEMA), and anabasine. 1) Cigarette smoking was associated with a dose dependent demethylation of cg05575921 and increased urinary CEMA and anabasine levels, 2) e-cigarette use did not demethylate cg05575921, 3) smokeless tobacco use also did not demethylate cg05575921 but was positively associated with anabasine levels 4) CEMA and cg05575921 levels were highly correlated and 5) propylene glycol levels did not reliably distinguish use groups. Cg05575921 assessments distinguish exposure to tobacco smoke from smokeless sources of nicotine including e-cigarettes and smokeless tobacco, neither of which are associated with cg05575921 demethylation. A combination of methylomic and metabolite profiling may allow for accurate classification use status of a variety of nicotine containing products.
Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects
Creators: name: Tian, Tian
name: Lai, Xinyuan
name: Xiang, Kuanhui
name: Han, Xiao
name: Yin, Shengju
name: Cabrera, Robert M.
name: Steele, John W.
name: Lei, Yunping
name: Cao, Xuanye
name: Finnell, Richard H.
name: Wang, Linlin
name: Ren, Aiguo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Neural tube defects (NTDs) are a group of common and severe congenital malformations. The PI3K-AKT signalling pathway plays a crucial role in the neural tube development. There is limited evidence concerning any possible association between aberrant methylation in PI3K-AKT signalling pathway genes and NTDs. Therefore, we aimed to investigate potential associations between aberrant methylation of PI3K-AKT pathway genes and NTDs. Methylation studies of PI3K-AKT pathway genes utilizing microarray genome-methylation data derived from neural tissues of ten NTD cases and eight non-malformed controls were performed. Targeted DNA methylation analysis was subsequently performed in an independent cohort of 73 NTD cases and 32 controls to validate the methylation levels of identified genes. siRNAs were used to pull-down the target genes in human embryonic stem cells (hESCs) to examine the effects of the aberrant expression of target genes on neural cells. As a result, 321 differentially hypermethylated CpG sites in the promoter regions of 30 PI3K-AKT pathway genes were identified in the microarray data. In target methylation analysis, CHRM1, FGF19, and ITGA7 were confirmed to be significantly hypermethylated in NTD cases and were associated with increased risk for NTDs. The down-regulation of FGF19, CHRM1, and ITGA7 impaired the formation of rosette-like cell aggregates. The down-regulation of those three genes affected the expression of PAX6, SOX2 and MAP2, implying their influence on the differentiation of neural cells. This study for the first time reported that hypermethylation of PI3K-AKT pathway genes such as CHRM1, FGF19, and ITGA7 is associated with human NTDs.
title: #DefendingTheDefenders – Episode 6: The European Union
Creators: name: Kokott, Lennart
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 342

description: In the sixth episode of our rule of law podcast #DefendingTheDefenders with Deutscher Anwaltverein, we talk about the European Union and the state of the professional freedom of attorneys there. Within the jurisdiction of the European Union, there are a number of issues attorneys and their associations are worried about. The right to defence and legal services as well as the attorney-client-relationship is being targeted in an unjustified manner in areas such as the fight against money laundering or terrorism as well as in sanctions packages against Russian corporations in the wake of Russia’s ongoing war against Ukraine, they say. EU institutions feel differently, however. They see the instruments under criticism as a proportionate way to address the professional freedom of lawyers as well as the right to defence on the one side and general interests on the other side. We talk to both sides to learn more about the concerns and the regulators‘ reasons. Our guests in this episode are James MacGuill, the president of the Council of Bars and Law Societies in Europe (CCBE) in 2022, and Florian Geyer, Head of Unit in the Directorate-General for Justice and Consumers at the European Commission.
description: Verfassungsblog: On Matters Constitutional
Determining the level of motivation and attitude of students for classes in physical education in higher education institutions
Creators: name: Taniana Pavlenko
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Pressing questions of the motivation of students to attend physical education classes in high schools. Shows the level of their physical fitness. Presented by the personal attitude to studies and evaluated for a target orientation, forms and practical training. The study involved 79 students. It was stated that the motivation of students to the motor activity generated from them is wrong. Found that the greatest preference is given to students of the development of force: a meager 26 students (33%), flexibility - 20 students (25.3%), speed - 18 students (22.8%), endurance - 11 students (13.9 %), agility - 4 students (5%). The data on the poor state of physical fitness of today's youth and its negative attitude to physical education and sport.
Analysis of the relationship of lifestyle and some of the parameters of respiratory diseases of children 7 - 9 years old in Poland and Ukraine
Creators: name: Radziyevska, Mariya
name: Knotowicz, J.
name: Radziyevsky, P.A.
name: DybaT.G.
name: Nesterova, T.V.
name: Dyba, E.V.
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Purpose - defining the relationship between the state of knowledge in the field of preventive health care, lifestyle characteristics, health status of students 7-9 years after an illness of the respiratory system. Developed a diagnostic system for the study of health status and level of physical fitness. Anthropometric measurements were carried out and samples Genchi and Stange, heart rate, blood pressure at rest. The level of adaptation was determined by the method of R.M. Baevsky. Opinion of parents, morphology and function, and medical records 553 students of secondary schools of Kiev and 538 students of Szczecin and Konin. Found that the incidence of respiratory systematically increased. It was found that the lack of physical activity of the body is 60-75% needed to maintain the health and development of physical standards. The ratio of 28 hours of lessons on general subjects with 2 hours of physical training per week in school indicates non-compliance with the physiological regulation of mental and physical stress during the growth and development of children.
Extension manual on production of quality catfish seed
Creators: name: Fregene, Bernadette Tosan
name: Bolorunduro, Paul
name: Yossa, Rodrigue
name: Karisa, Harrison C.
name: Ajibola  Olaniyi
name: Ajose, Israel
Publisher: name: Gates Open Research
Year: 2024

description: The "Extension Manual on Production of Quality Catfish Seed" is designed to enhance aquaculture productivity and improve the livelihoods of fish farmers in Africa. Developed by WorldFish under the TAAT program, this manual addresses the challenges in producing high-quality catfish fingerlings.

Focusing on best management practices (BMPs) for hatcheries, it covers broodstock selection, hatchery operations, fish health management, and business planning. The African catfish (Clarias gariepinus), known for its fast growth and hardiness, is a key species targeted in these efforts.

This manual aims to equip extension workers and fish farmers with the knowledge and skills needed to produce healthy, fast-growing catfish fingerlings, thereby boosting productivity and profitability. This initiative supports sustainable aquaculture practices across Africa, contributing to enhanced food security and economic development.
Schiff Base Complexes of Di(2-Pyridyl) Ketone Derivatives with Transition Metals, Synthesis and Characterization
Creators: name: A.O.Ebune, N.M.Bello, K.B Ahmad, A.S Oknakpa, A.Shehu
Publisher: name: Zenodo
Year: 2025

description: This study focuses on the synthesis of novel Schiff bases derived from aminopyridine and ketone, followed bytheir complexation with transition metals to form coordination compounds. The structure of these complexes was evaluated.The classical method of Schiff base synthesis which involves refluxing at 70°C for 5 hours, followed by solvent removal using a rotary evaporatorwas employed in this study. In the synthesis process, di(2-pyridyl) ketone is dissolved in absolute methanol, then combined with a solution of 2-aminopyridine, followed by refluxing. Transition metal salts in methanol were added, and further refluxing occurs. After crystallization and filtration, the products were formed and subjected to characterization using solubility test, melting point, molar conductivity, elemental analysis, and FTIR spectroscopy. The compounds show varied properties, with melting points from 123°C to 298°C, and conductivity ranging from 12.4 µScm-1 to 21.2 µScm-1, indicating nonelectrolytic behaviour. Elemental analysis validates experimental accuracy. FTIR spectra reveal imine bond formation in synthesized compounds. Coordination with metals is evident in complex spectra. Notably, M-N and M-Cl absorptions suggest metal-ligand bonding.The ligands exhibit both bidentate and monodentate coordination with transition metals, leading to diverse geometries, including octahedral.
DNA Methylation Differentiates Smoking from Vaping and Non-combustible Tobacco Use.
Creators: name: Andersen, Allan
name: Reimer, Rachel
name: Dawes, Kelsey
name: Becker, Ashley
name: Hutchens, Natasha
name: Miller, Shelly
name: Dogan, Meesha
name: Hundley, Brandon
name: Mills, James A
name: Long, Jeffrey D
name: Philibert, Robert
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Background: Increasing use of non-combusted forms of nicotine such as e-cigarettes poses important public health questions regarding their specific risks relative to combusted tobacco products such as cigarettes. To fully delineate these risks, improved biomarkers that can distinguish between these forms of nicotine use are needed. Prior work has suggested that methylation status at cg05575921 may serve as a specific biomarker of combusted tobacco smoke exposure. We hypothesized combining this epigenetic biomarker with conventional metabolite assays could classify the type of nicotine product consumption. Therefore, we determined DNA methylation and serum cotinine values in samples from 112 smokers, 35 e-cigarette users, 19 smokeless tobacco users and 269 controls, and performed mass spectroscopy analyses of urine samples from all nicotine users and 22 verified controls to determine urinary levels of putatively nicotine product specific substances; propylene glycol, 2-cyanoethylmercapturic acid (CEMA) and anabasine. Results: 1) Cigarette smoking was associated with a dose dependent demethylation of cg05575921 and increased urinary CEMA and anabasine levels, 2) e-cigarette use did not demethylate cg05575921, 3) smokeless tobacco use also did not demethylate cg05575921 but was positively associated with anabasine levels 4) CEMA and cg05575921 levels were highly correlated and 5) propylene glycol levels did not reliably distinguish use groups. Conclusions: Cg05575921 assessments distinguish exposure to tobacco smoke from smokeless sources of nicotine including e-cigarettes and smokeless tobacco, neither of which are associated with cg05575921 demethylation. A combination of methylomic and metabolite profiling may allow for accurate classification use status of a variety of nicotine containing products.
Sesgos de género y masculinización de la ciencia escolar. Un estudio de casos de clases de ciencias naturales en escuelas sostenidas con fondos públicos de la región de Valparaíso
Creators: name: Venegas-Espinoza, J.
Publisher: name: Zenodo
Year: 2022
Subjects: Women, Science, CBHE, EU, gender, STEM, W-STEM, Latin-America

description: En el contexto del proyecto W-STEM ERASMUS + Capacity-building in Higher Education European Project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP) se ha celebrado la Conferencia Internacional W-STEM Chile los días 19 y 20 de abril de 2022 de forma presencial en Valparaíso (Chile), auspiciada por la Pontificia Universidad Católica de Valparaíso y por la Universidad Técnica Federico Santa María, tras más de dos años trabajando virtualmente por la pandemia mundial de COVID-19. La Dra. Jennifer Venegas-Espinoza impartió la conferencia titulada “Sesgos de género y masculinización de la ciencia escolar. Un estudio de casos de clases de ciencias naturales en escuelas sostenidas con fondos públicos de la región de Valparaíso”. En ella presenta como la forma de enseñar ciencias en primaria promueve saberes vinculados con una ciencia generizada tendiente a su masculinización.

description: The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
Extension manual on quality low-cost fish feed formulation and production
Creators: name: Fregene, Bernadette Tosan
name: Yossa, Rodrigue
name: Karisa, Harrison C.
name: Ajibola Olaniyi
name: Bolorunduro, Paul
Publisher: name: Gates Open Research
Year: 2024

description: The "Extension Manual on Quality Low-Cost Fish Feed Formulation and Production" by WorldFish provides comprehensive guidelines for producing affordable, high-quality fish feed. Targeted primarily at catfish breeders and other stakeholders in the aquaculture value chain, this manual addresses key challenges such as access to quality feed ingredients and the skills necessary for effective feed formulation.

Developed under the Technologies for African Agricultural Transformation (TAAT) program, this manual aims to enhance the productivity of fish farming by promoting best management practices (BMPs) in fish feed production. It covers essential topics including the nutritional requirements of fish, feed ingredient selection, formulation techniques, and business planning for sustainable feed production.

The manual supports extension workers, feed millers, and fish farmers in Africa by providing practical, context-specific solutions to improve fish growth, health, and overall farm profitability, thereby contributing to increased food security and better livelihoods.
Middle Bronze Age Drayton—A Deverel-Rimbury Cemetery Assemblage [from West Sussex, UK]
Creators: name: SEAGER THOMAS, Mike
Publisher: name: Artefact Services
Year: 2010
Subjects: Sussex prehistoric pottery
Deverel-Rimbury
Sussex Coastal Plain
Bronze Age cemetery
Sussex Bronze Age
Bucket Urn
Drayton Quarry

description: This report discusses the dominant fraction of a prehistoric pottery assemblage excavated at Drayton Quarry, West Sussex, UK. The greater part of the prehistoric assemblage from Drayton belongs to the Deverel-Rimbury pottery tradition. It comprises c. 60 kilograms of pottery. Most of this comes from 26 truncated, probable cinerary urns, belonging to a single large or several small cemeteries extending across the site. A smaller domestic-looking assemblage (comprising a wider range of pottery types) comes from the same general area but a more extendsive range of features. With one or two exceptions, the DR forms and fabrics are wholly characteristic of Sussex DR traditions, but the assemblage is of interest on a number of other counts. First amongst these are the configuration and condition of the urns, which provide internal evidence that most are cinerary urns, and the composition of the different feature-assemblages, both funerary and domestic-looking, and the similarities to and differences between these and other similarly interpreted regional assemblages. These support the foregoing interpretation and highlight a local depositional idiosyncrasy. Also of interest are the stony fills of several of the urns and the possible interpretation of these. Finally, we address the depositional, typological and fabric differences between pottery groups in the context both of radiocarbon dates from the site, and some local and non-local analogues, in the hope that this will begin the process of untangling individual expression in pottery making locally from developments that occurred in the DR tradition over time.
Hypermethylation of PI3K-AKT signaling pathway genes is associated with human neural tube defects
Creators: name: Tian, Tian
name: Lai, Xinyuan
name: Xiang, Kuanhui
name: Han, Xiao
name: Yin, Shengju
name: Cabrera, Robert M.
name: Steele, John W.
name: Lei, Yunping
name: Cao, Xuanye
name: Finnell, Richard H.
name: Wang, Linlin
name: Ren, Aiguo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Neural tube defects (NTDs) are a group of common and severe congenital malformations. The PI3K-AKT signaling pathway plays a crucial role in the neural tube development. There is limited evidence concerning any possible association between aberrant methylation in genes of the PI3K-AKT signaling pathway and NTDs. Therefore, we aimed to investigate potential associations between aberrant methylation of PI3K-AKT pathway genes and NTDs. Methylation studies of PI3K-AKT pathway genes utilizing microarray genome-methylation data derived from neural tissues of ten NTD cases and eight non-malformed controls were performed. Targeted DNA methylation analysis was subsequently performed in an independent cohort of 73 NTD cases and 32 controls to validate the methylation levels of identified genes. siRNAs were used to pull-down the target genes in human embryonic stem cells (hESCs) to examine the effects of the aberrant expression of target genes on neural cells. As a result, 321 differentially hypermethylated CpG sites in the promoter regions of 30 PI3K-AKT pathway genes were identified in the microarray data. In subsequent target methylation analysis, CHRM1, FGF19, and ITGA7 were confirmed to be significantly hypermethylated in NTD cases and were associated with increased risk for NTDs. The down-regulation of FGF19, CHRM1, and ITGA7 impaired the formation of rosette-like cell aggregates. Besides, the down-regulation of those three genes affected the expression of PAX6, SOX2 and MAP2, implying their influence on the differentiation of neural cells. This study for the first time reported that hypermethylation of PI3K-AKT pathway genes such as CHRM1, FGF19, and ITGA7 is associated with human NTDs.Keywords: Neural tube defects, PI3K-AKT signaling pathway, methylation
Gender differences in relation of students to sports activity
Creators: name: Marchenko, Oksana
Publisher: name: figshare
Year: 2013
Subjects: Education

description: The problem of gender approach in the modern physical education in schools is considered. The experiment was conducted with students of 5-11 grades of secondary schools in the city of Poltava in the amount of 419 people. By the experiment, the students were involved in I-year students (35 girls and 16 boys). It is noted that for the normal socialization are important sex and gender roles. They are associated with the awareness itself as the representative of a particular sex with the norms of behavior, characteristic of members of this sex. Show the direction of consideration for the interests, motivations, values in the process of physical education. Found that to attract students to the sports activity requires consideration of the physiological and morphological and functional characteristics of the individual through the process of gender mainstreaming in the school system.
Model features as the basis of preparation of boxers individualization principal level (elite)
Creators: name: Pavelec, Alexander
name: Ostyanov, V.N.
name: Maydanyuk, O.V.
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Purpose - to improve the system of training boxers of higher categories (elite). Individualization of the training process using the model characteristics special physical preparedness. Materials: The study was conducted during 2000-2010. Participated boxers national team of Ukraine in the amount of 43 people. Of those honored masters of sport - 6, masters of sports of international class - 16, masters of sports - 21. The average age of the athletes - 23.5 years. Results: justified and features a specially designed model of physical fitness boxing class. It is established that the boxers middle weight classes (64 - 75 kg) have an advantage over other boxers weight categories (light and after a hard) in the development of speed and strength endurance. The presented model characteristics can guide the professional fitness boxing (elite), as representatives of the sport. Conclusions: It is established that the structure of the special physical training boxers depends on many components, such as weight category, tactical fighter role, skill level, stage of preparation.
Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
Creators: name: Laplana, Marina
name: Bieg, Matthias
name: Faltus, Christian
name: Melnik, Svitlana
name: Bogatyrova, Olga
name: Gu, Zuguang
name: Muley, Thomas
name: Meister, Michael
name: Dienemann, Hendrik
name: Herpel, Esther
name: Amos, Christopher I.
name: Schlesner, Matthias
name: Eils, Roland
name: Plass, Christoph
name: Risch, Angela
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carcinoma (NSCLC) to identify novel, clinically targetable genes and mechanisms in carcinogenesis. A targeted bisulphite-sequencing approach was used to comprehensively investigate DNA methylation changes occurring within lung cancer risk regions in 17 NSCLC and adjacent normal tissue pairs. We report differences in differentially methylated regions between adenocarcinoma and squamous cell carcinoma. Among the minimal regions found to be differentially methylated in at least 50% of the patients, 7 candidates were replicated in 2 independent cohorts (n = 27 and n = 87) and the potential of 6 as methylation-dependent regulatory elements was confirmed by functional assays. This study contributes to understanding the pathways implicated in lung cancer initiation and progression, and provides new potential targets for cancer treatment.
The Unacceptable Spectre of Under-Aged Forced Marriage in Turkey
Creators: name: Öcal Apaydin, Bahar
name: Maviş, Volkan
Publisher: name: University of Bologna Law Review
Year: 2020
Subjects: Forced Marriage; Child Marriage; Women's Rights; Consent

description: In many respects, Turkey is an exception among Muslim countries. Whilst being a secular democratic state, Turkey still struggles, however, with some remnants of its religious and socio-cultural heritage. The issue of forced marriage of children is one of those issues. Marriage is commonly defined as a union concluded by parties with their full and free consent. If consent is lacking, a forced marriage occurs. In the case of a forced marriage, consent is lacking because one of the prospective spouses does not give her/his consent freely, or sometimes because she/he is incapable of giving consent because of her/his age. As a founding member of the Council of Europe, Turkey not only ratified the European Convention on Human Rights (ECHR) in 1954 and Protocol Nr. 1, but it has also ratified many of the core international documents on human rights and the rights of children, such as the U.N. Convention on the Rights of the Child, the U.N. Convention on the Elimination of All Forms of Discrimination against Women. Nevertheless, the forced marriage of children is still a prevalent social problem in Turkey, and in the majority of cases, girls are the victims of such practices. This article examines the factors behind the forced marriage of children in Turkey, while exploring the current legal background and Turkey’s international legal commitments to fight against such practices. Finally, the article suggests the reinforcement of available legal remedies in order to prevent the forced marriage of children
description: University of Bologna Law Review, Vol 5, No 1 (2020)
Addressing the Gender Gap in Computer Science
Creators: name: S. McKeever
name: A. O'Reilly
Publisher: name: Zenodo
Year: 2022
Subjects: Women, Science, CBHE, EU, gender, STEM, W-STEM, Latin-America; Gender Gap in Computer Science

description: In the context of the W-STEM ERASMUS + Capacity-building in Higher Education European Project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP), the W-STEM Chile International Conference was held on 19-20 April 2022 in Valparaíso (Chile), hosted by the Pontificia Universidad Católica de Valparaíso and the Universidad Técnica Federico Santa María, after more than two years working virtually on the global COVID-19 pandemic. The keynote by Susan McKeever and Ayesha O’Reilly, researchers of the TU Dublin, was devoted to address the gender gap in computer science in their institution.

description: The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
title: #DefendingTheDefenders – Episode 7: UN Special Rapporteur Margaret Satterthwaite
Creators: name: Kokott, Lennart
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 342

description: On the 24th of January, the Day of the Endangered Lawyer, we conclude our podcast with a conversation with Margaret Satterthwaite. She is a professor of Clinical Law at New York University and was appointed as United Nations Special Rapporteur on the independence of judges and lawyers in October 2022. In this season, we have been looking at the challenges and dangers lawyers and human rights defenders face in their work in many different countries. We have been talking about Poland, Belarus, Turkey, Afghanistan, Colombia and the European Union. From harassments over identifications of lawyers with their clients to media pressure, SLAPP suits, imprisonments and violent attacks, we have talked about a range of threats lawyers face particularly in countries where the rule of law is fragile or where there is democratic backsliding, but not only there. In this conversation, Margaret Sattertwhaite offers a global perspective on the topic of our podcast, the defence of the defenders. We talk about global trends in challenges to the independence of lawyers, and we talk about structural problems that need to be addressed to defend the defenders around the globe. In addition, we circle back to Afghanistan, the country in focus of this year’s Day of the Endangered Lawyer, and the horrific situation of lawyers, in particular women, there.
description: Verfassungsblog: On Matters Constitutional
ANALYSIS OF THE CURRENT SITUATION OF THE MORTGAGE MARKET OF UZBEKISTAN
Creators: name: Abdullayev, Muhammadsodiq
Publisher: name: Zenodo
Year: 2024

description: Today, the need for modern housing for a large segment of the population is increasing day by day. A mortgage loan is one of the effective means of solving social, economic and legal problems in our country. Also, the creation of favorable conditions for meeting the population's demand for housing is inextricably linked with the development and expansion of the system of long-term mortgage housing loans.
Additional file 1 of A phase III randomized clinical trial comparing laparoscopic radical hysterectomy based on open state with abdominal radical hysterectomy in patients with early-stage cervical cancer
Creators: name: Zhao, Xin
name: Liu, Yansong
name: Niu, Jumin
name: Shi, Yulin
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Mathematical Sciences not elsewhere classified
Cancer
Mental Health

description: Additional file 1. SPIRIT checklist.
The definition of psychological aspects in the formation of student-centered motivation of students for classes in physical education
Creators: name: Gruzhevsky, Valeriy
Publisher: name: figshare
Year: 2013
Subjects: Education

description: An analysis of the publications, which demonstrates the importance of the emotional state in the formation of motivation as a psychological phenomenon. Shows the impact of physical education on the state of mental and emotional stress. Presented scientific analysis of psycho-emotional states in the 3rd year students with the region of residence and ethnicity. The study used survey results found that the circumstances are displayed on the psycho-emotional state of students. In their view, were: irritability, lack of confidence, fatigue, concern, guilt, etc. These conditions are more common in women of ethnic groups and from rural areas. It should be noted that the girls are very carefully described their emotional state and chose the answer in the questionnaire (sometimes), this response was dominant. Young men in many positions were more restrained. It is established that the formation of student-centered motivation of students to physical education should be adjusted in their emotional state. In this strategy the learning process of physical education is built on individual, ethnic differences.
Modelling of technical tactical actions as the management factor competitive process and preparation of basketball players of high qualification
Creators: name: Doroshenko, Eduard
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Application of modelling indicators of technical-tactical actions in a control system of preparation and competitive process of basketball players is considered. In research the official statistical data of the European championship on basketball of 2013 is used. It is shown that modelling indicators of technical-tactical actions allow to form an optimum orientation of training process with application of specialised means at various stages of a year cycle of preparation, to supervise indicators of technical-tactical actions in competitive process. It is recommended as modelling to use following ranges of indicators of technical-tactical activity: (in one game): efficiency of two game point throws (44 - 48 %, throws in game in number 46 - 50); efficiency of three game point throws (35 - 39 %, throws in game in number 15 - 19); efficiency of penal throws (64 - 72 %, throws in game in number 16 - 21); indicators of a parity of the typed and passed points (1,2 - 1,3); ball selections (37 - 40); ball interceptions (6 - 10); goal passes (13 - 16); ball losses (12-14); the block-shot (2,5 - 3,0).
The dynamics of indicators of physical qualities of boys aged 10-13 years under the influence of different types of tourism activities
Creators: name: Taniana Grynova
name: Mulik, E.V.
Publisher: name: figshare
Year: 2013
Subjects: Education

description: Compared to the development of physical qualities of young men engaged in hiking, biking and water sports tourism. Shows the development of the physical qualities of young men who do not engage in sports clubs. The study involved 18 children (age 10-13 years) in each of the groups. Classes are held on standard programs tourist sports clubs, which provide for 216 hours per year (2 sessions per week with duration of 3 hours each). Determined that the long-term and systematic training tourism contribute to the level of physical fitness tourists. Found that different types of tourism have a different effect on the development of a variety of physical properties. Classes hiking more improves flexibility, agility and speed-strength, cycling - speed, agility, and speed-strength, water tourism - force.
Transversalización de la perspectiva de género en Ingeniería y Ciencias. Experiencia de la Facultad de Ciencias Físicas y Matemáticas – Universidad de Chile
Creators: name: Gerdtzen, Z.
Publisher: name: Zenodo
Year: 2022
Subjects: Women, Science, CBHE, EU, gender, STEM, W-STEM, Latin-America

description: En el contexto del proyecto W-STEM ERASMUS + Capacity-building in Higher Education European Project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP) se ha celebrado la Conferencia Internacional W-STEM Chile los días 19 y 20 de abril de 2022 de forma presencial en Valparaíso (Chile), auspiciada por la Pontificia Universidad Católica de Valparaíso y por la Universidad Técnica Federico Santa María, tras más de dos años trabajando virtualmente por la pandemia mundial de COVID-19. Ziomara Gerdtzen, Directora de la Dirección de Diversidad y Género de la Universidad de Chile, impartió la conferencia titulada “Transversalización de la perspectiva de género en Ingeniería y Ciencias. Experiencia de la Facultad de Ciencias Físicas y Matemáticas – Universidad de Chile”. En ella presenta la evolución de la presencia de la mujer en esta Facultad hasta la creación de la Dirección de Diversidad y Género, que tiene como objetivos:
 • Promover una cultura inclusiva en la Facultad de Ciencias Físicas y Matemáticas.
 • Aumentar la representación de diversidades en todos los estamentos y áreas de la Facultad de Ciencias Físicas y Matemáticas.
 • Generar y difundir conocimiento sobre políticas y prácticas equitativas en STEM.
 • Transversalizar el enfoque de género.

description: The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
On fast calculation of square roots and logarithms
Creators: name: Camosso, Simone
Publisher: name: figshare
Year: 2021
Subjects: classificationCode: 490401
subject: Algebra and number theory

description: In this brief article we review basic algorithms for a fast calculation of square roots and logarithms. The necessity to have
“good” approximations of these mathematical entities arises
from the ancient Chinese civilization.
Improving athletic performance of basketball student team with the classical yoga exercises
Creators: name: Brinzak, Savva
name: Burko, S.V.
Publisher: name: figshare
Year: 2013
Subjects: Education

description: The results of the study of the effect of yoga exercises on the preparedness of the student basketball team. The study involved 25 athletes aged 17-20 years. The experimental group consisted of 13 players dealt in accordance with the proposed set of yoga exercises, which were used in the introductory, preparatory and final part. In the main part of the problem solved basketball directions. Classes in both groups were conducted 4 times a week for 2 hours for 9 months. Found that the use of exercises yoga pose direct impact on the physical indicators of preparedness players. Found an increase in the level of indicators: vertical jump, speed endurance, speed, retention of equilibrium (balance), free throw, with the movement, three-point shots, free throws, tactical execution.