cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplemental Material, Supplement_JICM_revision1_v3 - A Tool to Predict Readmission to the Intensive Care Unit in Surgical Critical Care Patients—The RISC Score
Creators: name: Hammer, Maximilian
name: Grabitz, Stephanie D.
name: Teja, Bijan
name: Wongtangman, Karuna
name: Serrano, Marjorie
name: Neves, Sara
name: Siddiqui, Shahla
name: Xinling Xu
name: Eikermann, Matthias
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, Supplement_JICM_revision1_v3 for A Tool to Predict Readmission to the Intensive Care Unit in Surgical Critical Care Patients—The RISC Score by Maximilian Hammer, Stephanie D. Grabitz, Bijan Teja, Karuna Wongtangman, Marjorie Serrano, Sara Neves, Shahla Siddiqui, Xinling Xu and Matthias Eikermann in Journal of Intensive Care Medicine
Supplementary_File_Detailing_Procedures_for_Calculating_Composite_Effect_Sizes – Supplemental material for Production and comprehension of pronouns in individuals with autism: A meta-analysis and systematic review
Creators: name: Finnegan, Elizabeth G
name: Asaro-Saddler, Kristie
name: Zajic, Matthew C
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, Supplementary_File_Detailing_Procedures_for_Calculating_Composite_Effect_Sizes for Production and comprehension of pronouns in individuals with autism: A meta-analysis and systematic review by Elizabeth G Finnegan, Kristie Asaro-Saddler and Matthew C Zajic in Autism
Mariner: explore the Hi-Cs
Creators: name: Phanstiel, Douglas H
name: Kramer, Nicole E
name: Parker, Sarah M
name: Davis, Eric S
name: Flores, J P
name: Kiran, Manjari
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: MOTIVATION: 3D chromatin structure plays an important role in regulating gene expression and alterations to this structure can result in developmental abnormalities and disease. While genomic approaches like Hi-C and Micro-C can provide valuable insights in 3D chromatin architecture, the resulting datasets are extremely large and difficult to manipulate. RESULTS: Here, we present mariner, a rapid and memory efficient tool to extract, aggregate, and plot data from Hi-C matrices within the R/Bioconductor environment. Mariner simplifies the process of querying and extracting contacts from multiple Hi-C files using a parallel and block-processing approach. Modular functions allow complete workflow customization for advanced users, yet all-in-one functions are available for running the most common types of analyses. Finally, tight integration with existing Bioconductor infrastructure enables complete analysis and visualization of Hi-C data in R. AVAILABILITY AND IMPLEMENTATION: Available on GitHub at https://github.com/EricSDavis/mariner and on Bioconductor at https://www.bioconductor.org/packages/release/bioc/html/mariner.html.
Morseidora acuta Cadena-Castañeda & Quintana-Arias & Infante & Silva & Tavares 2025, comb. nov.
Creators: name: Cadena-Castañeda, Oscar J.
name: Quintana-Arias, Ronald Fernando
name: Infante, Ivette Coque
name: Silva, Daniela Santos Martins
name: Tavares, Gustavo Costa
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tetrigidae
Morseidora
Morseidora acuta

description: Morseidora acuta (Günther, 1939), comb. nov.
(Fig. 58)
Metrodora acuta Günther, 1939: 294. Holotype: male, ECUADOR: Loja: Loja. Depository: MZPW.
Remarks. Here, this species is transferred from Metrodora to the genus Morseidora gen. nov.
description: Published as part of Cadena-Castañeda, Oscar J., Quintana-Arias, Ronald Fernando, Infante, Ivette Coque, Silva, Daniela Santos Martins & Tavares, Gustavo Costa, 2025, Studies on pygmy grasshoppers: On the current Metrodorinae sensu lato classification (Orthoptera: Tetrigidae) with emphasis on American and Malagasy taxa, pp. 1-265 in Zootaxa 5597 (1) on page 90, DOI: 10.11646/zootaxa.5597.1.1, http://zenodo.org/record/14966503
Additional file 1 of Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study
Creators: name: Cronjé, Héléne T.
name: Karhunen, Ville
name: Hovingh, G. Kees
name: Coppieters, Ken
name: Lagerstedt, Jens O.
name: Nyberg, Michael
name: Gill, Dipender
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1: Table S1. Instrument SNPs used for NPR2- and NPR3-predicted height. Table S2. Mendelian randomization results of genome-wide, NPR2-, and NPR3-predicted height on cardiovascular disease risk, risk factors and comorbidities. Table S3. Instrument SNPs used for NPR3-predicted SBP. Table S4. Mendelian randomization results of genome-wide, and NPR3-predicted SBP on cardiovascular disease risk. Table S5. Colocalization results for the genetic associations between NPR2- and NPR3-predicted height and cardiovascular disease risk and risk factors. Table S6. Mendelian randomization statistical sensitivity analyses for the associations between NPR3-predicted height and cardiovascular disease risk and systolic blood pressure.
The Pipe Roll for 1295, Surrey Membrane (1924)
Creators: name: Wills, MH
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 7, 1-63
description: The Surrey section of the Exchequer Pipe Roll for the period Michaelmas 1294 to Michaelmas 1295 [TNA ref E 372/140]. Edited with translation. This volume has become the classical elucidation of this aspect of medieval finance. Serial number 21. Paperback reprint (1968)
Lambeth Churchwardens' Accounts 1504-1645 and Vestry Book 1610 Part 2 (1941)
Creators: name: Drew, Charles
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 18, 133-292
description: An edition of the earliest surviving churchwardens' account book for the parish of St Mary, Lambeth, covering the years 1504/5 to 1645; and the first vestry minute book covering 1610-1693 (originals held by London Metropolitan Archives). Part 2 containing the second portion of the text of the churchwardens' account book (pp.133-292) covering the years 1579-1617
Masked convolutional neural network for supervised learning problems
Creators: name: Liu, Yufeng
name: Liu, Leo Yu-Feng
name: Zhu, Hongtu
Publisher: name: Wiley
Year: 2020

description: Convolutional neural networks (CNNs) have exhibited superior performance in various types of classification and prediction tasks, but their interpretability remains to be low despite years of research effort. It is crucial to improve the ability of existing models to interpret deep neural networks from both theoretical and practical perspectives and to develop new neural network models with interpretable representations. The aim of this paper is to propose a set of novel masked CNN (MCNN) models with better ability to interpret networks and more accurate prediction. The key ideas behind MCNNs are to introduce a latent binary network to extract informative regions of interest that contain important signals for prediction and to integrate the latent binary network with CNNs to achieve better prediction in various supervised learning problems. Extensive numerical studies demonstrate the competitive performance of the proposed MCNN models.
Lambeth Churchwardens' Accounts 1504-1645 and Vestry Book 1610 Part 4 (1950)
Creators: name: Drew, Charles
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 18, 277-434
description: An edition of the earliest surviving churchwardens' account book for the parish of St Mary, Lambeth, covering the years 1504/5 to 1645; and the first vestry minute book covering 1610-1693 (originals held by London Metropolitan Archives). Part 4 containing appendix and index
Chertsey Abbey Cartularies Volume 1 Part 3 (1932)
Creators: name: Guiseppi, MS
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 12, 279-427
description: Edition of the 15th century cartulary in The National Archives (TNA E 164/25) with other illustrative matter. Part 3 of volume 1 containing continuation of introduction (pp.xxiii-xxxiv) and calendar entries 473-664 (on pp.279-376) and an index to the whole of volume 1
Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort
Creators: name: Mhango, Wilberforce
name: Gopal, Satish
name: Tomoka, Tamiwe
name: Fedoriw, Yuri
name: Kaimila, Bongani
name: Krysiak, Robert
name: Zuze, Takondwa
name: Chiyoyola, Sarah
name: Kampani, Coxcilly
name: Montgomery, Nathan D.
name: Chimzimu, Fred
name: Painschab, Matthew S.
name: Chikasema, Maria
name: Mtangwanika, Asekanadziwa
name: Dhungel, Bal M.
name: Shea, Thomas C.
name: Mulenga, Maurice
name: Tewete, Blessings
name: Nyirenda, Ruth
name: Nyasosela, Richard
name: Kasonkanji, Edwards
Publisher: name: Wiley
Year: 2018

description: Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are poorly described. We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled in Malawi 2013-2017. Participants were treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive for human immunodeficiency virus (HIV+). Eighty-six participants (mean age 47 years, standard deviation 13) were enrolled: 54 (63%) were male and 51 (59%) were HIV+, of whom 34 (67%) were on ART at DLBCL diagnosis. Median CD4 count was 0·113 cells x 109 /l (interquartile range [IQR] 0·062-0·227) and 25 (49%) had HIV viral load <400 copies/μl. Participants received median six cycles CHOP (IQR 4-6). No patients were lost to follow-up and the 2-year overall survival was 38% (95% confidence interval 28-49). In multivariable analyses, Eastern Cooperative Oncology Group performance status (PS) ≥2 and lactate dehydrogenase (LDH) >2x upper limit of normal (ULN) were associated with mortality. HIV status was not associated with mortality. A simplified prognostic model of LDH >2x ULN and PS ≥2 performed at least as well as the age-adjusted International Prognostic Index. DLBCL can be successfully treated in SSA and outcomes did not differ by HIV status. A simplified prognostic model prognosticates well and may be easier to use in resource-limited settings but requires validation.
Mechanisms of Electrochemical N2 Splitting by a Molybdenum Pincer Complex
Creators: name: Malakar, Santanu
name: Miller, Alexander J. M.
name: Goldman, Alan S.
name: Bruch, Quinton J.
Publisher: name: American Chemical Society (ACS)
Year: 2022

description: Molybdenum complexes supported by tridentate pincer ligands are exceptional catalysts for dinitrogen fixation using chemical reductants, but little is known about their prospects for electrochemical reduction of dinitrogen. The viability of electrochemical N2 binding and splitting by a molybdenum(III) pincer complex, (pyPNP)MoBr3 (pyPNP = 2,6-bis(tBu2PCH2)-C5H3N)), is established in this work, providing a foundation for a detailed mechanistic study of electrode-driven formation of the nitride complex (pyPNP)Mo(N)Br. Electrochemical kinetic analysis, optical and vibrational spectroelectrochemical monitoring, and computational studies point to two concurrent reaction pathways: In the reaction-diffusion layer near the electrode surface, the molybdenum(III) precursor is reduced by 2e- and generates a bimetallic molybdenum(I) Mo2(μ-N2) species capable of N-N bond scission; and in the bulk solution away from the electrode surface, over-reduced molybdenum(0) species undergo chemical redox reactions via comproportionation to generate the same bimetallic molybdenum(I) species capable of N2 cleavage. The comproportionation reactions reveal the surprising intermediacy of dimolybdenum(0) complex trans,trans-[(pyPNP)Mo(N2)2](μ-N2) in N2 splitting pathways. The same "over-reduced" molybdenum(0) species was also found to cleave N2 upon addition of lutidinium, an acid frequently used in catalytic reduction of dinitrogen.
Mechanisms underlying the control of dynamic regulatory element activity and chromatin accessibility during metamorphosis
Creators: name: McKay, Daniel J
name: Niederhuber, Matthew J
Publisher: name: Elsevier
Year: 2020

description: Cis-regulatory modules of metazoan genomes determine the when and where of gene expression during development. Here we discuss insights into the genetic and molecular mechanisms behind cis-regulatory module usage that have come from recent application of genomics assays to insect metamorphosis. Assays including FAIRE-seq, ATAC-seq, and CUT&RUN indicate that sequential changes in chromatin accessibility play a key role in mediating stage-specific cis-regulatory module activity and gene expression. We review the current understanding of what controls precisely coordinated changes in chromatin accessibility during metamorphosis and describe evidence that points to systemic hormone signaling as a primary signal to trigger genome-wide shifts in accessibility patterns and cis-regulatory module usage.
Data from: Responses of subsoil organic carbon to climate warming and cooling is determined by microbial community rather than its molecular composition
Creators: name: Li, Yuzhang
name: Wei, Yao
name: He, Lile
name: Fan, Bo
name: Liu, Kunhe
name: Ding, Mingli
name: Hu, Yigang
name: Jin, Xin
name: Zhu, Biao
name: Wang, Shiping
name: He, Jin-Sheng
name: Zhao, Xinquan
name: Zhang, Zhenhua
Publisher: name: Zenodo
Year: 2025
Subjects: warming
cooling
alpine grassland
plant-derived molecular components
microbial-derived molecular components
microbial community properties

description: Little is currently known about how long-term climate changes modulate the relationship between soil organic carbon (SOC) molecular composition, microbial community and SOC storage, and the mechanisms involved. Here, we show substantial changes in subsoil SOC in the Qinghai-Tibetan alpine grasslands over 16 years of soil warming and cooling. Warming reduced SOC content by 8.5%, while cooling increased it by 7.0%. Neither warming nor cooling affected plant- and microbial-derived molecular components. However, warming elevated fungal-to-bacterial biomass ratio (F/B) and gram-positive to gram-negative bacterial biomass ratio (G+/G-) by 15.0% and 8.6%, respectively, whereas cooling reduced them by 4.5% and 9.6%. Warming reduced SOC storage by directly increasing F/B and G+/G- and indirectly decreasing the soil carbon-to-nitrogen ratio, whereas cooling enhanced SOC storage primarily by decreasing F/B. Conventional warming experiments, which consider only climate warming and neglect cooling, may underestimate the negative impacts of warming on subsoil SOC pools in alpine grasslands.
Abstracts of Surrey Feet of Fines 1509-1558 (1946)
Creators: name: Meekings, CAF
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 19, 1-179
description: The enormous series of Feet of Fines in The National Archives, enrolled among the records of the Court of Common Pleas, is a vital source to local and family historians, documenting as it does conveyances and agreements relating to the transfer of land. In 1894 Surrey Archaeological Society, published a volume listing Surrey Fines from the reign of Richard I to that of Henry VII and this volume documents in fuller detail fines of the reigns of Henry VIII, Edward VI and Mary I. It includes a meticulous introduction by C A F Meekings, the renowned legal historian. Two parts in one. Paperback reprint (1968).
Mechanistic investigation of a visible light mediated dehalogenation/cyclisation reaction using iron( iii ), iridium( iii ) and ruthenium( ii ) photosensitizers
Creators: name: Troian-Gautier, Ludovic
name: Elias, Benjamin
name: Sampaio, Renato N.
name: Cadranel, Alejandro
name: Singleton, Michael L.
name: De Kreijger, Simon
name: Aydogan, Akin
name: Meyer, Gerald J.
name: Caui«t, Emilie
name: Dickenson, John C.
name: Bangle, Rachel E.
Publisher: name: Royal Society of Chemistry (RSC)
Year: 2021

description: The identification of reaction mechanisms unique to the iron, ruthenium, and iridium PS represents progress towards the long-sought goal of utilizing earth-abundant, first-row transition metals for emerging energy and environmental applications. The mechanism of a visible light-driven dehalogenation/cyclization reaction was investigated using ruthenium( ii ), iridium( iii ) and iron( iii ) photosensitizers by means of steady-state photoluminescence, time-resolved infrared spectroscopy, and nanosecond/femtosecond transient absorption spectroscopy. The nature of the photosensitizer was found to influence the product distribution such that the dehalogenated, non-cyclized products were only detected for the iron photosensitizer. Strikingly, with the iron photosensitizer, large catalytic yields required a low dielectric solvent such as dichloromethane, consistent with a previous publication. This low dielectric solvent allowed ultrafast charge-separation to outcompete geminate charge recombination and improved cage escape efficiency. Further, the identification of reaction mechanisms unique to the iron, ruthenium, and iridium photosensitizer represents progress towards the long-sought goal of utilizing earth-abundant, first-row transition metals for emerging energy and environmental applications.
title: Computerliebe. KI-Partner*innen im Film
Creators: name: Beaufaÿs, Sandra
Publisher: name: DuEPublico
Year: 2024
Subjects: classificationCode: 5.4
subject: FOS: Sociology
classificationCode: 5.8
subject: FOS: Media and communications

description: Die idealisierten Rollen, die Frauen und Männer (in dieser Dualität auftretend) in romantischen Spielfilmen einnehmen, stoßen uns zuweilen schmerzlich darauf, dass die heterosexuelle Liebesbeziehung kein machtfreier Raum ist. Ein Kontrastprogramm zu den üblichen Girl-meets-Boy-Schnulzen bieten die Filme Her (USA, 2013, R: Spike Jonze) und Ich bin dein Mensch (D, 2021, R: Maria Schrader), in denen jeweils die Annäherung zwischen einem menschlichen und einem KI-betriebenen Pendant durchgespielt wird. Die Filme eröffnen eine interessante Reflexionsgrundlage, um zu räsonieren, wie die Geschlechterordnung in technisch verwirklichten ‚Idealpartner*innen‘ bzw. in Interaktion mit ihnen wirksam bleibt oder auch unterlaufen wird.
Lambeth Churchwardens' Accounts 1504-1645 and Vestry Book 1610 Part 1 (1940)
Creators: name: Drew, Charles
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 18, 1-134
description: An edition of the earliest surviving churchwardens' account book for the parish of St Mary, Lambeth, covering the years 1504/5 to 1645; and the first vestry minute book covering 1610-1693 (originals held by London Metropolitan Archives). Part 1 containing introduction (pp.vii-lix) and the first portion of the text of the churchwardens' account book (pp.1-134) covering the years 1504-1579
Digital Library Information Communication Process, Media and Diffusion: a Analysis
Creators: name: Khan, Dr. Abdul Musref
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Library sciences

description: Modern digital library role of information communication is progress under ICT (Information Communication Technology) moderate, feature of library conception machine barcode label provide particular information source indicate location library resource RAFID technology, Information is multimedia in nature comprising text, pictures, drawings, audio, video, animation and computer graphics. When represented in digital form, information of any kind appears as a string of ones and zeros. This helps in building systems that are capable of handling ones and zeros only and such systems can be made very robust. This is the underlying consideration for adopting digital technology. A large volume of information in nature appears in analogy form that requires to be converted to digital form. The advent of Information and Communication Technology (ICT) has offered a tremendous opportunity to generate new knowledge, disseminate, distribute, and provide access and many other facilities cutting across space.
Medical Image Synthesis with Deep Convolutional Adversarial Networks
Creators: name: Petitjean, Caroline
name: Lian, Jun
name: Wang, Li
name: Trullo, Roger
name: Shen, Dinggang
name: Nie, Dong
name: Wang, Qian
name: Ruan, Su
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2018

description: Medical imaging plays a critical role in various clinical applications. However, due to multiple considerations such as cost and radiation dose, the acquisition of certain image modalities may be limited. Thus, medical image synthesis can be of great benefit by estimating a desired imaging modality without incurring an actual scan. In this paper, we propose a generative adversarial approach to address this challenging problem. Specifically, we train a fully convolutional network (FCN) to generate a target image given a source image. To better model a nonlinear mapping from source to target and to produce more realistic target images, we propose to use the adversarial learning strategy to better model the FCN. Moreover, the FCN is designed to incorporate an image-gradient-difference-based loss function to avoid generating blurry target images. Long-term residual unit is also explored to help the training of the network. We further apply Auto-Context Model to implement a context-aware deep convolutional adversarial network. Experimental results show that our method is accurate and robust for synthesizing target images from the corresponding source images. In particular, we evaluate our method on three datasets, to address the tasks of generating CT from MRI and generating 7T MRI from 3T MRI images. Our method outperforms the state-of-the-art methods under comparison in all datasets and tasks.
Supplemental Material, ONLINE_SUPPLEMENT - Prognostic Significance of Preoperative Neutrophil-Lymphocyte Ratio in Vascular Surgery: Systematic Review and Meta-Analysis
Creators: name: Jackson, Sarah M.
name: Perry, Luke A.
name: Borg, Carla
name: Dhruvesh M. Ramson
name: Campbell, Ryan
name: Zhengyang Liu
name: Nguyen, Jacqueline
name: Douglas, Ned
name: Kok, Juliana
name: Penny-Dimri, Jahan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental Material, ONLINE_SUPPLEMENT for Prognostic Significance of Preoperative Neutrophil-Lymphocyte Ratio in Vascular Surgery: Systematic Review and Meta-Analysis by Sarah M. Jackson, Luke A. Perry, Carla Borg, Dhruvesh M. Ramson, Ryan Campbell, Zhengyang Liu, Jacqueline Nguyen, Ned Douglas, Juliana Kok and Jahan Penny-Dimri in Vascular and Endovascular Surgery
Metabolic and functional impairment of CD8+ T cells from the lungs of influenza-infected obese mice
Creators: name: Beck, Melinda A
name: Gowdy, Kymberly M
name: Al-Shaer, Abrar E
name: Shaikh, Saame Raza
name: Green, William D
name: MacIver, Nancie J
name: Milner, J Justin
name: Shi, Qing
Publisher: name: Oxford University Press (OUP)
Year: 2021

description: Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pulmonary CD8+ T cell metabolism, cytokine production, and transcriptome as a potential mechanism of impairment during influenza virus infection in mice. Male C57BL/6J lean and obese mice were infected with sub-lethal mouse-adapted A/PR/8/34 influenza virus, generating a pulmonary anti-viral and inflammatory response. Extracellular metabolic flux analyses revealed pulmonary CD8+ T cells from obese mice, compared with lean controls, had suppressed oxidative and glycolytic metabolism at day 10 post-infection. Flow cytometry showed the impairment in pulmonary CD8+ T cell metabolism with obesity was independent of changes in glucose or fatty acid uptake, but concomitant with decreased CD8+ GrB+ IFNγ+ populations. Notably, the percent of pulmonary effector CD8+ GrB+ IFNγ+ T cells at day 10 post-infection correlated positively with total CD8+ basal extracellular acidification rate and basal oxygen consumption rate. Finally, next-generation RNA sequencing revealed complex and unique transcriptional regulation of sorted effector pulmonary CD8+ CD44+ T cells from obese mice compared to lean mice following influenza infection. Collectively, the data suggest diet-induced obesity increases influenza virus pathogenesis, in part, through CD8+ T cell-mediated metabolic reprogramming and impaired effector CD8+ T cell function.
Repeat database, RNA annotation, Interproscan analysis result and software and algorithms for Correlophus ciliatus
Creators: name: Huang, Ruyi
name: Zhang, Jinghang
name: Lu, Liang
name: Huang, Song
name: Li, Chenhong
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310508
subject: Genome structure and regulation

description: Supplemental_File1 for InterProScan-5.69-101.0 resultSupplemental_File2 for base on RepeatModeler2 database RepeatMasker resultSupplemental_File3 for repeat sequences database, from RepeatModeler2Supplemental_File4 for RNA annotationSupplemental_File5 for Software and algorithms used in the article
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate
Creators: name: Bivins, Marissa M.
name: Sekela, Josh J.
name: Borlandelli, Valentina B.
name: Overkleeft, Hermen
name: Sorgen, Alicia A.
name: Redinbo, Matthew. R.
name: Simpson, Joshua B.
name: Bhatt, Aadra P.
name: Mordant, Angie L.
name: Barker, Natalie K.
name: Johnson, Rebecca L.
name: Graboski, Amanda L.
name: Lee, John R.
name: Herring, Laura E.
name: Fodor, Anthony A.
Publisher: name: Taylor & Francis
Year: 2022

description: Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the drug, mycophenolic acid (MPA), undergoes extensive enterohepatic recirculation by bacterial β-glucuronidase (GUS) enzymes, which reactivate MPA from mycophenolate glucuronide (MPAG) within the gastrointestinal tract. GUS enzymes demonstrate distinct substrate preferences based on their structural features, and gut microbial GUS enzymes that reactivate MPA have not been identified. Here, we compare the fecal microbiomes of transplant recipients receiving MMF to healthy individuals using shotgun metagenomic sequencing. We find that neither microbial composition nor the presence of specific structural classes of GUS genes are sufficient to explain the differences in MPA reactivation measured between fecal samples from the two cohorts. We next employed a GUS-specific activity-based chemical probe and targeted metaproteomics to identify and quantify the GUS proteins present in the human fecal samples. The identification of specific GUS enzymes was improved by using the metagenomics data collected from the fecal samples. We found that the presence of GUS enzymes that bind the flavin mononucleotide (FMN) is significantly correlated with efficient MPA reactivation. Furthermore, structural analysis identified motifs unique to these FMN-binding GUS enzymes that provide molecular support for their ability to process this drug glucuronide. These results indicate that FMN-binding GUS enzymes may be responsible for reactivation of MPA and could be a driving force behind MPA-induced GI toxicity.
Supplemental Material, sj-docx-1-tpx-10.1177_0192623320950633 - Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of Göttingen Minipigs
Creators: name: Hvid, Henning
name: Skydsgaard, Mikala
name: Jensen, Nikolai K.
name: Viuff, Birgitte M.
name: Jensen, Henrik E.
name: Oleksiewicz, Martin B.
name: Kvist, Peter H.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-1-tpx-10.1177_0192623320950633 for Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of Göttingen Minipigs by Henning Hvid, Mikala Skydsgaard, Nikolai K. Jensen, Birgitte M. Viuff, Henrik E. Jensen, Martin B. Oleksiewicz and Peter H. Kvist in Toxicologic Pathology
Metal-Organic Coordination Polymer for Delivery of a Subunit Broadly Acting Influenza Vaccine
Creators: name: Moore, Kathryn M.
name: Duggan, Eliza
name: Amouzougan, Eva A.
name: Ross, Ted M.
name: Eckshtain-Levi, Meital
name: Lifshits, Liubov M.
name: Stiepel, Rebeca T.
name: Bachelder, Eric M.
name: Batty, Cole J.
name: McCammitt, Brandon
name: Ainslie, Kristy M.
Publisher: name: American Chemical Society (ACS)
Year: 2022

description: A zinc-carnosine (ZnCar) metal-organic coordination polymer was fabricated in biologically relevant N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid (HEPES) buffer for use as a vaccine platform. In vitro, ZnCar exhibited significantly less cytotoxicity than a well-established zeolitic imidazolate framework (ZIF-8). Adsorption of CpG on the ZnCar surface resulted in enhanced innate immune activation compared to soluble CpG. The model antigen ovalbumin (OVA) was encapsulated in ZnCar and exhibited acid-sensitive release in vitro. When injected intramuscularly on days 0 and 21 in C57BL/6 mice, OVA-specific serum total IgG and IgG1 were significantly greater in all groups with ZnCar and antigen compared to soluble controls. Th1-skewed IgG2c antibodies were significantly greater in OVA and CpG groups delivered with ZnCar for all time points, regardless of whether the antigen and adjuvant were co-formulated in one material or co-delivered in separate materials. When broadly acting Computationally Optimized Broadly Reactive Antigen (COBRA) P1 influenza hemagglutinin (HA) was ligated to ZnCar via its His-tag, significantly greater antibody levels were observed at all time points compared to soluble antigen and CpG. ZnCar-formulated antigen elicited increased peptide presentation to B3Z T cells in vitro and production of IL-2 after ex vivo antigen recall of splenocytes isolated from vaccinated mice. Overall, this work displays the formation of a zinc-carnosine metal-organic coordination polymer that can be applied as a platform for recombinant protein-based vaccines.
Repeat database, RNA annotation and Interproscan analysis result for Correlophus ciliatus
Creators: name: Huang, Ruyi
name: Zhang, Jinghang
name: Lu, Liang
name: Huang, Song
name: Li, Chenhong
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310508
subject: Genome structure and regulation

description: .cmscan and .tblout file for RNA annotation_repmodeler_db.fa for repeat sequences database, from RepeatModeler2_repmasker.tbl file for base on RepeatModeler2 database RepeatMasker resultipscan_result.txt file for InterProScan-5.69-101.0 result
Additional file 1 of Arts on prescription intervention for primary healthcare patients with poor mental health or social isolation: a mixed-method study
Creators: name: Jensen, Anita
name: Halling, Anders
name: Pirouzifard, Mirnabi
name: Lindström, Martin
Publisher: name: figshare
Year: 2025
Subjects: Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health
Computational Biology

description: Supplementary Material 1
Surrey Hearth Tax 1664 (1940)
Creators: name: Meekings, CAF
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 17, 1-194
description: An edition of the 1664 Surrey Heath Tax roll in The National Archives (in class E 179), comprising a detailed introduction (pp.ix-cxxxix) including transcripts of select illustrative documents and analytical tables; followed by an alphabetical list by surname (pp.1-176); and a general index. Two parts in one, serial numbers 41, 42.
Method G: Uncertainty Quantification for Distributed Data Problems Using Generalized Fiducial Inference
Creators: name: Hannig, Jan
name: Lee, Thomas C. M.
name: Lai, Randy C. S.
Publisher: name: Taylor & Francis
Year: 2021

description: It is not unusual for a data analyst to encounter datasets distributed across several computers. This can happen for reasons such as privacy concerns, efficiency of likelihood evaluations, or just the sheer size of the whole dataset. This presents new challenges to statisticians as even computing simple summary statistics such as the median becomes computationally challenging. Furthermore, if other advanced statistical methods are desired, then novel computational strategies are needed. In this article, we propose a new approach for distributed analysis of massive data that is suitable for generalized fiducial inference and is based on a careful implementation of a "divide-and-conquer" strategy combined with importance sampling. The proposed approach requires only small amount of communication between nodes, and is shown to be asymptotically equivalent to using the whole dataset. Unlike most existing methods, the proposed approach produces uncertainty measures (such as confidence intervals) in addition to point estimates for parameters of interest. The proposed approach is also applied to the analysis of a large set of solar images. Supplementary materials for this article are available online.
Methodological Considerations in Scale Refinement with Diverse Populations: A Case Example Using the CES-D with a Community Sample of American Indian Women
Creators: name: Knafl, George J.
name: Berry, Diane C.
name: Adams, Leslie B.
name: Corbie-Smith, Giselle M.
name: Woods-Giscombé, Cheryl L.
name: Currin, Emily G.
name: Brooks, Jada L.
Publisher: name: Taylor & Francis
Year: 2022

description: Although many psychometric assessments are used extensively in population-based research to determine psychopathology, these tools have not been thoroughly validated or appropriately adapted for use in diverse populations. Indeed, depression measurement studies among American Indian and female populations are scarce, omitting key opportunities to tailor psychological measurement for this population. To build psychometric evidence of measures in this population, we used a procedural method to examine a standard psychological instrument-the Center for Epidemiological Studies Depression Scale (CES-D)-with a community sample of southeast American Indian women. Our results showed strong psychometric reliability of the 20-item CES-D. The "effort" item presented diminished validity, as demonstrated by a negative counter-intuitive item-to-total correlation (ITC) value. Dropping the "effort" item resulted in a 19-item scale with a better fit in the within-group examination of community-based American Indian women. Compared to the 20-item CES-D scale, the revised 19-item measure ("effort" item removed) resulted in minimal changes to women's depression categories. However, we did detect patterns in shifts such that the 19-item scale generally underestimated (i.e., placed women in a lower category) depressive symptoms compared to the 20-item scale. Depending on their study goals, researchers engaging in population-based research should carefully weigh the use of original scales that allow for consistency in reporting with refined scales that fit psychometrically. We present the outlined method as a tool that expands on current approaches in scale refinement, and aids researchers in making more informed decisions regarding refined scales with diverse populations.
The 1258-9 Special Eyre of Surrey and Kent (2004)
Creators: name: H Hershey, Andrew
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 38, 1-322
description: In 1258-9 the recently appointed justiciar of England, Hugh Bigod, visited Surrey and Kent to hear the complaints and pleas brought to him by commissions of knights appointed in each county. Bigod's appointment was a key part of the enforcement of the proposals for the reform of Henry III's government, the Provisions of Oxford, which the king was obliged to accept in June 1258. The surviving plea roll, transcribed and translated here, allows researchers access to a key source for the quality of local government during the personal rule of Henry III and the grievances against local officials and royal favourites which had fed this crisis in the king's reign.
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Creators: name: Parsonnet, Julie
name: Liu, LinShu
name: Cloer, Erica W.
name: Beaty, Violet V.
name: Overkleeft, Hermen S.
name: Goldfarb, Dennis
name: Zhang, Guodong
name: Minter, Lisa M.
name: Jariwala, Parth B.
name: Redinbo, Matthew R.
name: Yang, Jun
name: Xiao, Hang
name: Gibbons, John G.
name: Yeliseyev, Vladimir
name: Walker, Morgan E.
name: Panigrahy, Anand
name: Wang, Guangqiang
name: Zhang, Hongna
name: Simpson, Joshua B.
name: Li, Zhengze
name: Kim, Daeyoung
name: Zhao, Ermin
name: Haggerty, Thomas D.
name: Chacon-Vargas, Katherine
name: Zhang, Jianan
name: Yang, Haixia
name: Liang, Yanshan
name: Major, Michael B.
name: Borlandelli, Valentina
name: Sanidad, Katherine Z.
name: Cai, Zongwei
Publisher: name: Springer Nature
Year: 2022

description: Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. While the intestinal toxicities of TCS require the presence of gut microbiota, the molecular mechanisms involved have not been defined. Here we show that intestinal commensal microbes mediate metabolic activation of TCS in the colon and drive its gut toxicology. Using a range of in vitro, ex vivo, and in vivo approaches, we identify specific microbial β-glucuronidase (GUS) enzymes involved and pinpoint molecular motifs required to metabolically activate TCS in the gut. Finally, we show that targeted inhibition of bacterial GUS enzymes abolishes the colitis-promoting effects of TCS, supporting an essential role of specific microbial proteins in TCS toxicity. Together, our results define a mechanism by which intestinal microbes contribute to the metabolic activation and gut toxicity of TCS, and highlight the importance of considering the contributions of the gut microbiota in evaluating the toxic potential of environmental chemicals.
Minutes of the Board of Directors of the Reading, Guildford and Reigate Railway Company (1987)
Creators: name: Course, Edwin
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 33, 1-338
description: The coming of the railway to Surrey permanently transformed the county in the mid 19th century. This volume records the minutes of the Board of Directors of the Reading, Guildford and Reigate Railway Company from 1845 when the line was first proposed, through the cutting of the first sod in 1847, the opening of the line in 1849, and the company's amalgamation with the South Eastern Railway Company in 1852. The financing, tendering process, construction of the railway and the interaction of the company with the local populace and with other local transport undertakings are chronicled in the minutes.
Additional file 1 of The cost of the diagnostic odyssey of patients with suspected rare diseases
Creators: name: Glaubitz, Rick
name: Heinrich, Luise
name: Tesch, Falko
name: Seifert, Martin
name: Reber, Katrin Christiane
name: Marschall, Ursula
name: Schmitt, Jochen
name: Müller, Gabriele
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Supplementary_table_1 - Development of new or worsening headache after cochlear implant activation: A hypothesis-generating pilot study of incidence, timing, and clinical factors
Creators: name: Riggins, Nina
name: Chae, Ricky
name: Levin, Morris
name: Ehrlich, Annika
name: Sawhney, Henna
name: Polite, Colleen
name: Goadsby, Peter J
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplementary_table_1 for Development of new or worsening headache after cochlear implant activation: A hypothesis-generating pilot study of incidence, timing, and clinical factors by Nina Riggins, Ricky Chae, Morris Levin, Annika Ehrlich, Henna Sawhney, Colleen Polite and Peter J Goadsby in Cephalalgia Reports
Correlophus ciliatus genome assembly
Creators: name: Huang, Ruyi
name: Zhang, Jinghang
name: Lu, Liang
name: Huang, Song
name: Li, Chenhong
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310509
subject: Genomics

description: We generated a high-quality chromosome-level genome assembly of the crested gecko by combining Nanopore, Illumina, and Hi-C data. The genome assemble has a size of 1.66 Gb, with scaffold N50 of 109.97 Mb, and 99.52% of the scaffold anchored on 19 chromosomes. The BUSCO analysis indicated a gene completeness of 90.3% (n=7,480), including 6,673 (89.2%) single-copy genes and 84 (1.1%) duplicated genes. Additionally, we identified 21,065 protein-coding genes using the MAKER3 annotation toolkit, with 41.98% (697.51 Mb) consisting of repetitive elements. Among these, 21,037 genes were validated through InterProScan5.
Additional file 1 of Production, purification, characterization and application of two novel endoglucanases from buffalo rumen metagenome
Creators: name: Meng, Zhenxiang
name: Yang, Chengjian
name: Leng, Jing
name: Zhu, Weiyun
name: Cheng, Yanfen
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Fig. S1a. The predicted secondary structure of TrepCel3. Fig. S1b. The predicted secondary structure of TrepCel4.
Supplement_table_1 – Supplemental material for Dyslipidemia in HIV-Infected Children and Adolescents on Antiretroviral Therapy Receiving Care at Kilimanjaro Christian Medical Centre in Tanzania: A Cross-Sectional Study
Creators: name: Irira, Michael E
name: Philemon, Rune N
name: Mmbaga, Joshua Y
name: Komba, Venancia
name: Bartlett, John
name: Kinabo, Grace D
name: Mmbaga, Blandina T
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, Supplement_table_1 for Dyslipidemia in HIV-Infected Children and Adolescents on Antiretroviral Therapy Receiving Care at Kilimanjaro Christian Medical Centre in Tanzania: A Cross-Sectional Study by Michael E Irira, Rune N Philemon, Joshua Y Mmbaga, Venancia Komba, John Bartlett, Grace D Kinabo and Blandina T Mmbaga in Infectious Diseases: Research and Treatment
title: Learning Quality Inventory for In-Company Training in VET (VET-LQI)
Creators: name: Deutscher, V.
name: Böhn, S.
Publisher: name: ZIS - GESIS Leibniz Institute for the Social Sciences
Year: 2023
Subjects: subject: Vocational Training
subject: In-Company Training
subject: Training Quality
subject: Apprentice Questionnaire
subject: VET
subject: Training Quality Survey

description: The “Learning Quality Inventory for In-Company Training in VET” (VET-LQI) is a survey instrument aiming for a valid and comprehensive measurement of vocational training quality in companies. The validated instrument comprises 22 short scales with 76 items, enabling a broad approach to the construct of training quality. The survey instrument was developed by conducting a qualitative meta-synthesis of all existing instruments regarding training quality. 43 test instruments were integrated into the general theoretical framework on workplace learning by Tynjälä (2013). Item and confirmatory factor analyses (CFA) indicate satisfactory reflection of all common workplace characteristics regarding validity and reliability*. Overall, the VET-LQI overcomes the limited applicability of prior instruments by covering all identified content areas of training quality from the literature.
*Except for ‘Relevance of Tasks’ (Scale 7), which is still included to maintain a broad coverage of the construct vocational training quality.
description: ZIS - The Collection of Items and Scales for the Social Sciences
Additional file 1 of An unbeatable opponent? Coaches’ perspectives on the impact of climate change in outdoor sports
Creators: name: Schneider, Sven
name: Reinmuth, Janina
name: Leer, Sophie
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
Surrey Probate Inventories 1558-1603 (2005)
Creators: name: Herridge, Marion
Publisher: name: Archaeology Data Service
Year: 2024

description: Surrey Record Society Monographs, 39, 1-558
description: For any student of the domestic interior, levels of wealth, the circulation of goods, the tools and utensils of various trades, indeed of the material surroundings in which people from all sections of society lived out their lives, probate inventories are a fundamental source. The inventories and valuations of domestic goods were drawn up after a person's death as part of the process of proving the will and this volume brings together transcripts of surviving inventories from the reign of Elizabeth I. Together they provide a fascinating window on the way people lived, from the bustle of Southwark to the remote rural areas in the south of the county.
Additional file 1 of Disparity in access to orthopedic surgery between public and private healthcare insurance: a nationwide population-based study
Creators: name: Lira, María Jesús
name: Pino, Paula
name: Vidal, Catalina
name: Mery, Pamela
name: Irarrázaval, Sebastián
name: Cerda, Jaime
name: Vergara, Jorge
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Annex 1
Mimicking Biological Recognition: Lessons in Binding Hydrophilic Guests in Water
Creators: name: Harrison, Emily E.
name: Johns, Hannah P. Ferguson
name: Waters, Marcey L.
name: Stingley, Kyla J.
Publisher: name: Wiley
Year: 2021

description: Selective molecular recognition of hydrophilic guests in water plays a fundamental role in a vast number of biological processes, but synthetic mimicry of biomolecular recognition in water still proves challenging both in terms of achieving comparable affinities and selectivities. This Review highlights strategies that have been developed in the field of supramolecular chemistry to selectively and non-covalently bind three classes of biologically relevant molecules: nucleotides, carbohydrates, and amino acids. As several groups have systematically modified receptors for a specific guest, an evolutionary perspective is also provided in some cases. Trends in the most effective binding forces for each class are described, providing insight into selectivity and potential directions for future work.