cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessment of myelination in infants and young children by T1 relaxation time measurements using the magnetization-prepared 2 rapid acquisition gradient echoes sequence
Creators: name: Kühne, Fabienne
name: Neumann, Wolf-Julian
name: Hofmann, Philip
name: Marques, José
name: Kaindl, Angela M.
name: Tietze, Anna
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Children
subject: Infants
subject: Magnetic resonance imaging
subject: Magnetization-prepared 2 rapid acquisition gradient echoes
subject: Myelination
subject: R1 relaxometry
subject: Reference measurements
subject: T1 measurements
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Axonal myelination is an important maturation process in the developing brain. Increasing myelin content correlates with the longitudinal relaxation rate (R1=1/T1) in magnetic resonance imaging (MRI). Objective: By using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) on a 3-T MRI system, we provide R1 values and myelination rates for infants and young children. Materials and methods: Average R1 values in white and grey matter regions in 94 children without pathological MRI findings (age range: 3 months to 6 years) were measured and fitted by a saturating-exponential growth model. For comparison, R1 values of 36 children with different brain pathologies are presented. The findings were related to a qualitative evaluation using T2, magnetization-prepared rapid acquisition gradient echo (MP-RAGE) and MP2RAGE. Results: R1 changes rapidly in the first 16 months of life, then much slower thereafter. R1 is highest in pre-myelinated structures in the youngest subjects, such as the posterior limb of the internal capsule (0.74-0.76 +/- 0.04 s(-1)) and lowest for the corpus callosum (0.37-0.44 +/- 0.03 s(-1)). The myelination rate is fastest in the corpus callosum and slowest in the deep grey matter. R1 is decreased in hypo- and dysmyelination disorders. Myelin maturation is clearly visible on MP2RAGE, especially in the first year of life. Conclusion: MP2RAGE permits a quantitative R1 mapping method with an examination time of approximately 6 min. The age-dependent R1 values for children without MRI-identified brain pathologies are well described by a saturating-exponential function with time constants depending on the investigated brain region. This model can serve as a reference for this age group and to search for indications of subtle pathologies. Moreover, the MP2RAGE sequence can also be used for the qualitative assessment of myelinated structures.
Supplementary document for Digital labeling for 3D histology: segmenting blood vessels without vascular contrast agent using deep learning - 6313147.pdf
Creators: name: Lapierre-Landry, Maryse
name: Liu, Yehe
name: Bayat, Mahdi
name: Wilson, David
name: Jenkins, Michael
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Knowledge Representation and Machine Learning

description: supplemental figure 1-4
Challenges arising for older workers from participating in a workplace intervention addressing work ability: a qualitative study from Germany
Creators: name: Sippli, Khira
name: Schmalzried, Pia
name: Rieger, Monika A.
name: Voelter-Mahlknecht, Susanne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Aging workforce
subject: Aging
subject: Older worker
subject: Work ability
subject: Workplace intervention
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Studies examining what renders workplace interventions to sustain and promote work ability of older workers successful have largely neglected older workers ' perspective. This paper outlines the results of a study with regard to older workers ' experiences and expectations of a workplace intervention. Based on these findings, some reflections on how to improve the design and the implementation of workplace interventions for older workers are provided. Methods: Semi-structured interviews were conducted with older workers (N = 8) participating in a workplace intervention undertaken at one production site of a large manufacturing company in Baden-Wurttemberg/Germany. The interview guide included questions on participants ' experiences with and expectations of the intervention. The interviews were recorded, transcribed verbatim and analyzed using qualitative content analysis according to Mayring (2014). Results: Older workers' reported some challenges they face due to their participation in the workplace intervention. These resulted from the work environment (physical challenges), the work process design (new long work cycle), the work organization (tight time allowances, little job rotation, change of teams, age stereotypes) and the management of the workplace intervention (bad information, feeling of occupational insecurity and lack of being valued). Conclusions: The study shows that challenges arising for older workers from their participation in the workplace intervention may have counteracted the promotion of work ability. As findings suggest, some of these challenges might have been avoided either by considering workers ' perspective during design and implementation of an intervention or by referring to evidence on aging and work ability.
The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents
Creators: name: Scheer, Monika
name: Vokuhl, Christian
name: Bauer, Sebastian
name: Fuchs, Jörg
name: Loff, Steffan
name: Timmermann, Beate
name: Münter, Marc
name: Henssen, Anton George
name: Kazanowska, Bernarda
name: Niggli, Felix
name: Ladenstein, Ruth
name: Ljungman, Gustaf
name: Koscielniak, Ewa
name: Klingebiel, Thomas
name: European Cooperative Weichteilsarkom Studiengruppe [CWS]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Synovial sarcoma
subject: Soft-tissue sarcoma
subject: Pediatric sarcoma
subject: Adjuvant therapies
subject: Chemotherapy
subject: Radiotherapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The benefit of adjuvant therapy in synovial sarcoma (SS) treatment is under debate. Long-term follow-up data are missing. Methods: SS patients treated in the consecutive trials CWS-81, CWS-86, CWS-91, CWS-96, CWS-2002-P, and the SoTiSaR-registry till 2013 were analyzed. Results: Median age of 185 patients was 13.9 years (0.1-56)-with median follow-up of 7.4 years for 163 survivors. Most tumors (76%) were located in extremities. Size was < 3 cm in 58 (31%), 3-5 cm in 59 (32%), 5-10 cm in 42 (23%), and > 10 cm in 13 (7%) (13 missing). In 84 (45%) tumors, first excision was complete (R0 corresponding to IRS-I-group) and in 101 (55%) marginal (R1 corresponding to IRS-II-group). In a subsequent surgical intervention during chemotherapy, R0-status was accomplished in 23 additional IRS-II-group patients with secondary surgery. Radiotherapy was administered to 135 (73%), thereof 62 with R0-status and 67 R1-status (6 missing information). Adjuvant chemotherapy was administered to all but six patients. 5-year event-free (EFS) and overall survival (OS) was 82.9% +/- 5.7 (95%CI) and 92.5% +/- 3.9. Local and metastatic relapse-free survival was 91.3% +/- 4.3 and 92.3% +/- 4.1 at 5 years, respectively. In the multivariate analysis, tumor size and no chemotherapy were independently associated with EFS. Size and site were associated with OS. In a detailed analysis of local and metastatic events, tumor size was associated with an independent risk for developing metastases. No independent factor for suffering local recurrence could be identified. Discussion: Omission of chemotherapy in a non-stratified way seems not justified. Size governs survival due to high linear association with risk of suffering metastatic recurrence in a granular classification.
Effect of a common UMOD variant on kidney function, blood pressure, cognitive and physical function in a community-based cohort of older adults
Creators: name: Villagomez Fuentes, Linda Elizabeth
name: Algharably, Engi Abdel–Hady
name: Toepfer, Sarah
name: König, Maximilian
name: Demuth, Ilja
name: Bertram, Lars
name: Kreutz, Reinhold
name: Bolbrinker, Juliane
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: UMOD gene
subject: kidney function
subject: blood pressure
subject: cognitive and physical function
subject: older adults
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In genome-wide association studies, genetic variants in the UMOD gene associate with kidney function, blood pressure (BP), and hypertension. Elevated BP is linked to kidney function and impaired cognitive as well as physical performance in later life. We investigated the association between UMOD rs4293393-A > G and kidney function, BP, cognitive and physical function in the Berlin Aging Study II (BASE-II). Data of 1556 older BASE-II participants (mean age 68.2 +/- 3.7 years) were analyzed. BP was determined by standardized automated measurements, estimated glomerular filtration rate (eGFR) by CKD Epidemiology Collaboration creatinine equation. Cognitive function was assessed by Mini-Mental State Examination and Digit Symbol Substitution Test, while physical function by Handgrip Strength and Timed Up and Go-Test. Association analyses were performed by covariance and logistic regression models adjusting for sex. G-allele carriers at UMOD rs4293393 exhibited significantly higher eGFR values compared to non-carriers (AA, 76.4 ml/min/1.73 m(2), CI: 75.7-77.2 vs. AG, 78.4 ml/min/1.73 m(2), CI: 77.3-79.5 vs. GG, 78.5 ml/min/1.73 m(2), CI: 75.4-81.7; P = 0.010), and a lower risk of eGFR < 60 mL/min/1.73 m(2) (AG, OR: 0.63, CI: 0.41-0.97, P = 0.033). However, UMOD rs4293393 genotypes were not associated with BP, diagnosis of hypertension or cognitive and physical function parameters. Our data corroborate previous findings on the association of UMOD rs4293393-G with better kidney function in older adults. However, no association between UMOD and BP or physical and cognitive parameters in these community-dwelling older adults was detected.
Unveiling the structure of RNA using EPR spectroscopy
Creators: name: Papa, Maria
Publisher: name: The University of St Andrews
Year: 2023
Subjects: Click chemistry
Site directed spin labelling
Electron paramagnetic resonance (EPR)
Structural biology
RNA transcription

description: This thesis describes work on the application of Electron Paramagnetic Resonance (EPR) to long non-coding RNA (lncRNA), which are transcribed from non-protein coding regions present in the human genome. As little is known about lncRNA secondary and tertiary structures, investigating the correlation between their conformation and their function is of great interest. EPR is a spectroscopy technique used to analyse and identify chemical species defined as paramagnetic and since RNA is not, the labelling of RNA with radical probes is necessary. This is implemented through a technique called site directed spin labelling (SDSL), which consists in the transcription of RNA with suitably modified nucleotides triphosphate (NTP) in specific positions to which probes are attached. Labelling is implemented using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) and strain promoted alkyne-azide cycloaddition (SPAAC). These require two reactant species: an alkyne and an azide. Therefore, the aim is to synthesise spin labels and nucleotides suitably modified with these functional groups to allow spin labelling via click reaction. In St Andrews, the problems of labelling RNA for Förster resonance energy transfer (FRET) studies have been a focus of Professor Carlos Penedo. His group has worked on an enzymatic method for stepwise transcription and labelling of a long non-coding RNA, specifically a 71 nt pbuE bacterial riboswitch, using the T7 RNA Polymerase and Escherichia coli RNA polymerase (RNAP). Once the transcribed RNA has been obtained (modified at specific sites), the FRET labelling has been carried out incorporating fluorescent probes using click chemistry methods. In this way it was possible to study the riboswitch conformations using FRET spectroscopy. Following this approach, the aim of this thesis is to adapt the concept for producing spin-labelled RNA in sufficient quantity for EPR measurements. My aim is to demonstrate a post-transcriptional spin labelling approach to allow the incorporation spin labels at specific positions. I tested which modified-for-click RNA uridine (U) nucleotides can be incorporated via transcription, and I tested how feasible the click reaction is for spin labelling the RNA. Further, I developed the stepwise strategy for allowing the site directed spin labelling of long RNA at specific positions. Success in these approaches, and extension to other modified nucleotides, should lead to a flexible and high yielding method for producing spin-labelled RNA without limit on length (as for chemical approaches) or position (as for ligation).
Glycosylation is a key in SARS-CoV-2 infection
Creators: name: Reis, Celso A.
name: Tauber, Rudolf
name: Blanchard, Véronique
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: SARS-CoV-2
subject: Glycosylation
subject: Spike protein
subject: Blood group antigen
subject: Infection
subject: COVID-19
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing.
High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity
Creators: name: Bender, Katja
name: Perez, Eilís
name: Chirica, Mihaela
name: Onken, Julia
name: Kahn, Johannes
name: Brenner, Winfried
name: Ehret, Felix
name: Euskirchen, Philipp
name: Koch, Arend
name: Capper, David
name: Kaul, David
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: High-grade astrocytoma with piloid features
subject: HGAP
subject: Anaplastic astrocytoma with piloid features
subject: MC AAP
subject: Methylation-based classification
subject: Case series
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: High-grade astrocytoma with piloid features (HGAP) is a recently described brain tumor entity defined by a specific DNA methylation profile. HGAP has been proposed to be integrated in the upcoming World Health Organization classification of central nervous system tumors expected in 2021. In this series, we present the first single-center experience with this new entity. Methods: During 2017 and 2020, six HGAP were identified. Clinical course, surgical procedure, histopathology, genome-wide DNA methylation analysis, imaging, and adjuvant therapy were collected. Results: Tumors were localized in the brain stem (n = 1), cerebellar peduncle (n = 1), diencephalon (n = 1), mesencephalon (n = 1), cerebrum (n = 1) and the thoracic spinal cord (n = 2). The lesions typically presented as T1w hypo- to isointense and T2w hyperintense with inhomogeneous contrast enhancement on MRI. All patients underwent initial surgical intervention. Three patients received adjuvant radiochemotherapy, and one patient adjuvant radiotherapy alone. Four patients died of disease, with an overall survival of 1.8, 9.1, 14.8 and 18.1 months. One patient was alive at the time of last follow-up, 14.6 months after surgery, and one patient was lost to follow-up. Apart from one tumor, the lesions did not present with high grade histology, however patients showed poor clinical outcomes. Conclusions: Here, we provide detailed clinical, neuroradiological, histological, and molecular pathological information which might aid in clinical decision making until larger case series are published. With the exception of one case, the tumors did not present with high-grade histology but patients still showed short intervals between diagnosis and tumor progression or death even after extensive multimodal therapy.
Frequency and phenotype of thalamic aphasia
Creators: name: Rangus, Ida
name: Fritsch, Merve
name: Endres, Matthias
name: Udke, Birgit
name: Nolte, Christian H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Thalamus
subject: Stroke
subject: Aphasia
subject: Language
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Aphasia is a recognized presenting symptom of thalamic lesions. Little is known regarding its frequency and phenotype. We examined the frequency of thalamic aphasia following Isolated Acute unilateral ischemic Lesions in the Thalamus (IALT) with respect to lesion location. Furthermore, we characterized thalamic aphasia according to affected language domains and severity. Methods: Fifty-two patients with IALT were analyzed [44% female, median age: 73 years (IQR: 60-79)]. Lesion location was determined using 3-Tesla magnetic resonance imaging and categorized as anterior, posterior, paramedian or inferolateral. Standardized language assessment was performed using the validated Aphasia checklist (ACL) directly after symptom onset. Aphasia was defined as an ACL sum score of < 135 (range: 0-148). Results: Of 52 patients, 23 (44%) fulfilled the ACL diagnostic criteria for aphasia, including nearly all lesion locations and both sides. The average ACL sum score was 132 +/- 11 (range: 98-147). Aphasia was characterized by deficits within domains of complex understanding of speech and verbal fluency. Patients with left anterior IALT were most severely affected, having significantly lower ACL scores than all other patients (117 +/- 13 vs. 135 +/- 8; p < 0.001). In particular, aphasia in patients with left anterior IALT was characterized by significantly worse performance in the rating of verbal communication, verbal fluency, and naming (all p <= 0.001). Conclusion: Aphasia occurs in almost half of patients with focal thalamic lesions. Thalamic aphasia is not confined to one predefined thalamic lesion location, but language deficits are particularly pronounced in patients with left anterior IALT presenting with a distinct pattern.
Di-Gozd Digital Forest Inventory - Internet app
Creators: name: Gačo, Amina
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity and nature managment
Supply chain
Marketing and consumption
Wood mobilization

description: The online application helps users evaluate their forest land using public data and estimate annual yields. It allows users to analyze their own images, calculate tree values, and monitor forest events. Users gain insights into forest condition, interventions, and planned harvests.
Differences and Similarities in the Mechanisms and Clinical Expression of Bradykinin-Mediated vs. Mast Cell–Mediated Angioedema
Creators: name: Maurer, Marcus
name: Magerl, Markus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Angioedema
subject: Bradykinin
subject: Mast cell
subject: Hereditary angioedema
subject: Urticaria
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Angioedema (AE), transient localized swelling due to extravasated fluid, is commonly classified as mast cell mediator-induced, bradykinin-mediated or of unknown cause. AE often occurs more than once, and it is these recurrent forms of AE that are challenging for patients and physicians, and they are the ones we focus on and refer to as AE in this review. Since effective treatment depends on the causative mediator, reliable and early diagnosis is essential. Although their clinical presentations bear similarities, many forms of angioedema exhibit specific patterns of clinical appearance or disease history that may aid in diagnosis. Here, we describe the most common differences and similarities in the mechanisms and clinical features of bradykinin-mediated and mast cell mediator-induced types of angioedema. We first provide an overview of the diseases that manifest with mast cell mediator-induced versus bradykinin-mediated angioedema as well as their respective underlying pathogenesis. We then compare these diseases for key clinical features, including angioedema location, course and duration of swelling, attack frequency, prevalence and relevance of prodromal signs and symptoms, triggers of angioedema attacks, and other signs and symptoms including wheals, age of onset, and duration. Our review and comparison of the clinical profiles of different types of angioedema incorporate our own clinical experience as well as published information. Our aim is to highlight that mast cell mediator-induced and bradykinin-mediated angioedema types share common features but are different in many aspects. Knowledge of the differences in underlying pathomechanisms and clinical profiles between different types of angioedema can help with the diagnostic approach in affected patients and facilitate targeted and effective treatment.
Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum
Creators: name: Buelow, Markus
name: Süßmuth, David
name: Smith, Laurie D.
name: Aryani, Omid
name: Castiglioni, Claudia
name: Stenzel, Werner
name: Bertini, Enrico
name: Schuelke, Markus
name: Knierim, Ellen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: SPTBN4-related genetic spectrum
subject: SPTBN4-related phenotypic spectrum
subject: bi-allelic variants
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Neurodevelopmental disorder with hypotonia, neuropathy, and deafness (NEDHND, OMIM #617519) is an autosomal recessive disease caused by homozygous or compound heterozygous variants in SPTBN4 coding for type 4 beta IV-spectrin, a non-erythrocytic member of the beta-spectrin family. Variants in SPTBN4 disrupt the cytoskeletal machinery that controls proper localization of ion channels and the function of axonal domains, thereby generating severe neurological dysfunction. We set out to analyze the genetic causes and describe the clinical spectrum of suspected cases of NEDHND. Variant screening was done by whole exome sequencing; clinical phenotypes were described according to the human phenotype ontology, and histochemical analysis was performed with disease-specific antibodies. We report four families with five patients harboring novel homozygous and compound heterozygous SPTBN4 variants, amongst them a multi-exon deletion of SPTBN4. All patients presented with the key features of NEDHND; severe muscular hypotonia, dysphagia, absent speech, gross motor, and mental retardation. Additional symptoms comprised horizontal nystagmus, epileptiform discharges in EEG without manifest seizures, and choreoathetosis. Muscle histology revealed both characteristics of myopathy and of neuropathy. This report expands the SPTBN4 variant spectrum, highlights the spectrum of morphological phenotypes of NEDHND-patients, and reveals clinical similarities between the NEDHND, non-5q SMA, and congenital myopathies.
Cost-effectiveness of noninvasive telemedical interventional management in patients with heart failure: health economic analysis of the TIM-HF2 trial
Creators: name: Sydow, Hanna
name: Prescher, Sandra
name: Koehler, Friedrich
name: Koehler, Kerstin
name: Dorenkamp, Marc
name: Spethmann, Sebastian
name: Westerhoff, Benjamin
name: Wagner, Christoph J.
name: Liersch, Sebastian
name: Rebscher, Herbert
name: Wobbe-Ribinski, Stefanie
name: Rindfleisch, Heike
name: Müller-Riemenschneider, Falk
name: Willich, Stefan N.
name: Reinhold, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Heart failure
subject: Cost-effectiveness
subject: Health economics
subject: Telemedicine
subject: Remote patient management
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Noninvasive remote patient management (RPM) in patients with heart failure (HF) has been shown to reduce the days lost due to unplanned cardiovascular hospital admissions and all-cause mortality in the Telemedical Interventional Management in Heart Failure II trial (TIM-HF2). The health economic implications of these findings are the focus of the present analyses from the payer perspective. Methods and results: A total of 1538 participants of the TIM-HF2 randomized controlled trial were assigned to the RPM and Usual Care group. Health claims data were available for 1450 patients (n = 715 RPM group, n= 735 Usual Care group), which represents 94.3% of the original TIM-HF2 patient population, were linked to primary data from the study documentation and evaluated in terms of the health care cost, total cost (accounting for intervention costs), costs per day alive and out of hospital (DAOH), and cost per quality-adjusted life year (QALY). The average health care costs per patient year amounted to (Sic) 14,412 (95% CI 13,284-15,539) in the RPM group and (sic) (17,537 (95% CI 16,179-18,894) in the UC group. RPM led to cost savings of (sic) 3125 per patient year (p = 0.001). After including the intervention costs, a cost saving of (Sic) 1758 per patient year remained (p = 0.048). Conclusion: The additional noninvasive telemedical interventional management in patients with HF was cost-effective compared to standard care alone, since such intervention was associated with overall cost savings and superior clinical effectiveness. [GRAPHICS] .
Inanspruchnahme von Notaufnahmen durch sog. Mehrfachnutzer/-innen: Ergebnisse einer prospektiven Studie unter besonderer Berücksichtigung des Migrationsstatus
Creators: name: David, Matthias
name: Richter, Rolf
name: Naghavi, Baharan
name: Borde, Theda
name: Razum, Oliver
name: Somasundaram, Rajan
name: Stein, Hendrike
name: Sehouli, Jalid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Utilization
subject: Emergency
subject: Emergency room
subject: Migrants
subject: Migration background
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Can we identify predictive factors for the group of so-called multiple users (MU; 4 and more uses of an emergency department [ED] in the past 12 months)? Are people with a migration background more likely to be classified in the MU group? Methodology: Included were consecutive patients who visited three EDs in Berlin from July 2017 to July 2018. Using a questionnaire, diseases, reasons for visiting the ED and socioeconomic factors were recorded. Comparisons between migrants (1st generation), their descendants (2nd generation) and nonmigrants were assessed using logistic regression. Results: A total of 2339 patients were included in the evaluation (repeat rate 56%), of which 901 had a migration background. Young women (<30 years), chronically ill, pregnant women, patients with severe complaints and people with (self-assessed) moderate and poor health quality as well as those without medical referral had a greater chance of multiple use of ED. Conclusion: MU burden the already increasing patient volume of ED. However, they represent a heterogeneous group of patients, among whom people with a migration background are not common. Further research is warranted to better understand the factors that lead to frequent use and to develop effective strategies to address the complex health needs of MUs.
Dietary supplement use in ambulatory cancer patients: a survey on prevalence, motivation and attitudes
Creators: name: Tank, Maja
name: Franz, Kristina
name: Cereda, Emanuele
name: Norman, Kristina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Dietary supplements
subject: Dietary habits
subject: Patients with cancer
subject: Nutritional counselling
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Patients with cancer often believe dietary supplements (DS) such as micronutrients and botanical products to be health supporting and non-toxic despite growing concerns regarding potential pharmacological interactions. Studies on the prevalence of DS use among patients with cancer are heterogeneous and mainly conducted at university-based cancer centers. This survey focused on a particular cancer patient group treated in an ambulatory setting without regular access to professional nutritional counselling. Methods: Patients with a history of cancer or hematological malignancy were included in this survey. A self-reported questionnaire was used to evaluate the different aspects of DS use, changes in dietary habits and patients' demographic characteristics. Results: Almost every second patient reported using DS (47.2%). Women (56.3%), patients with an academic degree (56.0%) and non-smokers (84.8%) were more inclined to use DS. Along with magnesium (16.6%), calcium (14.3%), multivitamins (12.0%) and vitamin C (9.4%), use of herbal supplements (12.6%) was common. Women (84.8% vs. 74.9% of men, p = < 0.001) and patients younger than 65 years (84.4% vs. 77.2% of patients > 65 y, p = 0.002) sought dietary advice more often. Support of the immune system was the main reason for DS use (26.4%) and a relevant number of patients (49.6%) reported to have changed their dietary habits following cancer diagnosis. Conclusion: DS use is common among patients with cancer treated in an ambulatory setting. This finding should encourage oncologists to implement detailed questioning about DS use and dietary habits to prevent potential interactions and offer substantial advice.
Evaluation of a new body-focused group therapy versus a guided self-help group program for adults with psychogenic non-epileptic seizures (PNES): a pilot randomized controlled feasibility study
Creators: name: Senf-Beckenbach, Philine
name: Hoheisel, Matthias
name: Devine, Janine
name: Frank, Arnina
name: Obermann, Laura
name: Rose, Matthias
name: Hinkelmann, Kim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Psychogenic non-epileptic seizures
subject: Dissociative seizures
subject: Body psychotherapy
subject: Group psychotherapy treatment
subject: Randomized clinical feasibility study
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Psychogenic non-epileptic seizures (PNES), a common phenomenon in neurological settings, are regarded as a paroxysmal type of functional neurological disorder (FND). In a substantial proportion, PNES are disabling with poor long-term outcomes and high economic costs. Despite the clinical and financial consequences of PNES, there is still a lack of controlled clinical trials on the treatment of this challenging disorder. The study aims to evaluate the feasibility and collect first evidence of the efficacy of a group based-intervention in PNES-patients. Methods: A pilot randomized controlled feasibility study with a parallel-group design was performed in adult outpatients with PNES to evaluate a new body-focused group therapy (CORDIS) versus guided self-help groups. Self-assessment of dissociation (Dissociation Experience Scale-DES-20) and seizure severity (Liverpool Seizure Severity Scale-LSSS) were assessed two weeks before and two weeks after the treatment intervention and also six months after treatment as primary outcome parameters. Results: A total of 53 patients were recruited from a specialized outpatient clinic, and out of those, 29 patients completed either the body-focused group therapy program (n = 15) or a guided self-help group (SHG) therapy (n = 14). When analyzing the ITT sample (n = 22 CORDIS group, n = 20 SHG), both groups showed an effect on seizure severity and level of dissociation. In the per protocol sample (n = 13 CORDIS group, n = 12 SHG), CORDIS was superior to the self-help group for reducing seizure severity 6 months after the treatment. Significance: CORDIS is a newly developed body-focused group therapy program for adults with PNES. Further studies should include a multicentric design with a higher number of participants.
Supplementary document for Cone Contrast Test-HD: Sensitivity and Specificity in Red–green Dichromacy and the Impact of Age - 6313722.pdf
Creators: name: Iizuka, Tatsuya
name: Kawamorita, Takushi
name: Handa, Tomoya
name: Ishikawa, Hitoshii
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Figure S1 and Table S1
title: Behrend, Paul
title: Catalogus Professorum Halensis
titleType: Subtitle
title: Biografienportal Sachsen-Anhalt
titleType: Other
Creators: name: Catalogus Professorum Halensis
name: Eberle, Henrik
Publisher: name: Historisches Datenzentrum Sachsen-Anhalt,Institut für Landesgeschichte (Sachsen-Anhalt)
Year: 2025
Subjects: subject: History
classificationCode: 4023025-9
subject: Halle (Saale)
valueUri: https://d-nb.info/gnd/4023025-9
classificationCode: 4006804-3
subject: Biografie
valueUri: https://d-nb.info/gnd/4006804-3
classificationCode: 4166546-6
subject: Landesgeschichte
valueUri: https://d-nb.info/gnd/4166546-6
classificationCode: 4051181-9
subject: Sachsen-Anhalt
valueUri: https://d-nb.info/gnd/4051181-9
classificationCode: 1048495779
subject: Universität Halle (Saale) | Halle (Saale)
valueUri: https://d-nb.info/gnd/1048495779
classificationCode: 2024276-1
subject: Martin-Luther-Universität Halle-Wittenberg | Halle (Saale); Wittenberg
valueUri: https://d-nb.info/gnd/2024276-1
classificationCode: 4020517-4
subject: Geschichte
valueUri: https://d-nb.info/gnd/4020517-4
classificationCode: 7504326-9
subject: Universitätsgeschichte
valueUri: https://d-nb.info/gnd/7504326-9
classificationCode: 7504427-4
subject: Wissenschaftsgeschichte
valueUri: https://d-nb.info/gnd/7504427-4
subject: Biografienportal Sachsen-Anhalt
subject: Catalogus Professorum Halensis
classificationCode: 120134756
subject: Eberle, Henrik | 1970– | Historiker
valueUri: https://d-nb.info/gnd/120134756
classificationCode: 135894417
subject: Behrend, Paul Gerhard | 1853–1905 | Agrikulturchemiker
valueUri: https://d-nb.info/gnd/135894417

description: Das Biografienportal Sachsen-Anhalt versammelt in Erst- und Zweitveröffentlichung oder zu Zwecken der Langzeitarchivierung Biografien von Menschen aus und in Sachsen-Anhalt. Integriert wurde der Catalogus Professorum Halensis, der durch Mitarbeitende des Instituts für Geschichte der Martin-Luther-Universität Halle-Wittenberg entstand. Dabei handelt es sich um ein bio-bibliografisches Online-Lexikon zu den Professoren der Universität Halle zwischen 1694 und 1968. Die Texte wurden vor allem von Henrik Eberle und anderen Mitarbeitenden zwischen 2005 und 2010 recherchiert und erstellt. Etliche Artikel zum Zeitraum 1694 bis 1817 verfasste Julia Schopferer. Bei der Überführung in das Biografienportal wurden die Lebensangaben neu recherchiert und Metadaten über Verfahren des Named Entity Recogniton erschlossen. Automatisiert erkannt wurden Personennamen, Ortsbezeichnungen und Körperschaften, die in der hier vorhandenen RTF-Datei indexiert vorliegt. Zudem wurden diese mit GND-Einträgen abgeglichen. Weiterhin erfolgte ein Abgleich mit der „Ontologie der historischen, deutschsprachigen Amts- und Berufsbezeichnungen“. Die Texte liegen im Jahr 2024 in zweifacher Ausgabe im Catalogus Professorum Halensis des Universitätsarchivs und des Biografienportals des Historischen Datenzentrums Sachsen-Anhalts vor. Sie werden hier für die Langzeitarchivierung der ursprünglichen Fassung archiviert.
description: https://www.catalogus-professorum-halensis.de/
description: Biografienportal Sachsen-Anhalt: https://www.histdata.uni-halle.de/
Recursive Light Resonance Framework: A Unified Model of Emergent Particle Properties with Prediction of a Third Scalar Resonance at 285.3 GeV
Creators: name: Needham, Eric
Publisher: name: Zenodo
Year: 2025
Subjects: Recursive Resonance
Pi-Phi Framework
Emergent Particle Mass
Resolution Gap
Standard Model Particles
Scalar Resonance
First Principles Physics
Vacuum Structure
Recursive Harmonics
SMEFT
Effective Field Theory
Golden Ratio
Fundamental Constants
Particle Mass Formula
285.3 GeV Scalar Prediction
Needham Recursive Scaling
Light as Scaling Metric
Quantum Field Emergence

description: This paper extends the Pi-ϕ Light Framework to include a rigorous mathematical and physical derivation of three exact Standard Model particle masses—electron, muon, and proton—using only the mathematical constants π and ϕ. No empirical fitting or free parameters are introduced at any stage. We demonstrate that these masses emerge naturally from a unified recursive resonance structure, revealing a deeper generative order to the quantum vacuum.

The framework predicts and confirms known particle properties with extraordinary precision, and provides a testable pathway to future discoveries, including the confirmed resonances at 227.78 and 250.00 GeV, and a third predicted scalar resonance at 285.3 GeV.

This paper includes full code, derivations, and resonance shell structure, and is published alongside two prior studies detailing SMEFT resonance observations:

Observation of Scalar Resonances at 227.78 and 250.00 GeV: Interpretation within a ϕ-Extended Effective Field Theory Framework📄 https://doi.org/10.5281/zenodo.15353023

Observation of Novel Scalar Resonances at 227.8 and 250.0 GeV: Analysis Within an Extended SMEFT Framework and Prediction of a Third Resonance📄 https://doi.org/10.5281/zenodo.15341059

The convergence of independent theoretical methods and the emergence of resonance patterns from first principles strongly supports the Pi-ϕ Light Framework as a foundational model of mass emergence and vacuum symmetry.

 

If you would like more information about the ENSO Framework, contact Eric Needham: ensotheory1@gmail.com
Patient-specific resurfacing implant knee surgery in subjects with early osteoarthritis results in medial pivot and lateral femoral rollback during flexion: a retrospective pilot study
Creators: name: Moewis, Philippe
name: Kaiser, René
name: Trepczynski, Adam
name: Tycowicz, Christoph Von
name: Krahl, Leonie
name: Ilg, Ansgar
name: Holz, Johannes
name: Duda, Georg N.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Metallic resurfacing implants
subject: Episealer implants
subject: Osteoarthritis
subject: Focal chondral lesions
subject: Osteochondral lesions
subject: UKA
subject: TKA
subject: Knee kinematics
subject: Fluoroscopy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Metallic resurfacing implants have been developed for the treatment of early, small, condylar and trochlear osteoarthritis (OA) lesions. They represent an option for patients who do not fulfill the criteria for unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA) or are too old for biological treatment. Although clinical evidence has been collected for different resurfacing types, the in vivo post-operative knee kinematics remain unknown. The present study aims to analyze the knee kinematics in subjects with patient-specific episealer implants. This study hypothesized that patient-specific resurfacing implants would lead to knee kinematics close to healthy knees, resulting in medial pivot and a high degree of femoral rollback during flexion. Methods: Retrospective study design. Fluoroscopic analysis during unloaded flexion-extension and loaded lunge was conducted at > 12 months post-surgery in ten episealer knees, and compared to ten healthy knees. Pre- and post-operative clinical data of the episealer knees were collected using a visual analog scale (VAS), the EQ 5d Health, and the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaires. Results: A consistent medial pivot was observed in both episealer and healthy knees. Non-significant differences were found in the unloaded (p = 0.15) and loaded (p = 0.51) activities. Although lateral rollback was observed in both groups, it was significantly higher for the episealer knees in both the unloaded (p = 0.02) and loaded (p = 0.01) activities. Coupled axial rotation was significantly higher in the unloaded (p = 0.001) but not in the loaded (p = 0.06) activity in the episealer knees. Improved scores were observed at 1-year post-surgery in the episealer subjects for the VAS (p = 0.001), KOOS (p = 0.001) and EQ Health (p = 0.004). Conclusion: At 12 month follow-up, a clear physiological knee kinematics pattern of medial pivot, lateral femoral rollback and coupled axial external femoral rotation during flexion was observed in patients treated with an episealer resurfacing procedure. However, higher femoral rollback and axial external rotation in comparison to healthy knees was observed, suggesting possible post-operative muscle weakness and consequent insufficient stabilization at high flexion.
title: Der Weg zu Routinedaten aus 16 Notaufnahmen für die sektorenübergreifende Versorgungsforschung
title: Erfahrungen, Herausforderungen und Lösungsansätze aus der Extraktion pseudonymer Daten für das Projekt INDEED
titleType: Subtitle
Creators: name: Fischer-Rosinský, Antje
name: Slagman, Anna
name: King, Ryan
name: Zimmermann, Grit
name: Drepper, Johannes
name: Brammen, Dominik
name: Lüpkes, Christian
name: Reinhold, Thomas
name: Roll, Stephanie
name: Keil, Thomas
name: Möckel, Martin
name: Greiner, Felix
name: Behringer, Wilhelm
name: Bernhard, Michael
name: Blaschke, Sabine
name: Busch, Hans-Jörg
name: Erdmann, Bernadett
name: Flasch, Bernhard
name: Gries, André
name: Höger-Schmidt, Heike
name: Schöpke, Timo
name: Schwarz, Constanze
name: Somasundaram, Rajan
name: Weidmann, Erik
name: Wolfrum, Sebastian
name: Wrede, Christian
name: INDEED-Projekt
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Emergency care
subject: Data integration
subject: Secondary data
subject: Documentation
subject: Standardization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In Germany there is currently no health reporting on cross-sectoral care patterns in the context of an emergency department care treatment. The INDEED project (Utilization and trans-sectoral patterns of care for patients admitted to emergency departments in Germany) collects routine data from 16 emergency departments, which are later merged with outpatient billing data from 2014 to 2017 on an individual level. Aim: The methodological challenges in planning of the internal merging of routine clinical and administrative data from emergency departments in Germany up to the final data extraction are presented together with possible solution approaches. Methods: Data were selected in an iterative process according to the research questions, medical relevance, and assumed data availability. After a preparatory phase to clarify formalities (including data protection, ethics), review test data and correct if necessary, the encrypted and pseudonymous data extraction was performed. Results: Data from the 16 cooperating emergency departments came mostly from the emergency department and hospital information systems. There was considerable heterogeneity in the data. Not all variables were available in every emergency department because, for example, they were not standardized and digitally available or the extraction effort was judged to be too high. Conclusion: Relevant data from emergency departments are stored in different structures and in several IT systems. Thus, the creation of a harmonized data set requires considerable resources on the part of the hospital as well as the data processing unit. This needs to be generously calculated for future projects.
title: Collective Confinement: How Perceptions of Collective Efficacy Influence Feelings of Safety Among Individuals Living in Restricted Housing Units
Creators: name: Hartwell, Taylor Nicole
Publisher: name: George Mason University
Year: 2020
Subjects: subject: Solitary confinement
subject: Restricted housing units
subject: Perceptions of safety
subject: Collective efficacy

description: Solitary confinement (i.e., Restricted Housing Unit/RHU) is traditionally defined as a “prison within a prison” (Brown, Cambier, & Agha, 2011). Individuals residing in RHUs experience heightened rules including restricted movement and interaction. It is expected that these heightened restrictions will influence residents’ perceptions of collective efficacy and safety while residing in restricted housing. This research uses survey and semi-structured interview data collected from individuals residing in RHUs to explore perceptions of collective efficacy and safety, and more specifically examine how the presence/absence of collective efficacy influences perceptions of safety while living in RHUs. Implications for this research include extending theoretical concepts regarding collective efficacy and perceptions of safety in carceral environments. Additionally, this work provides insight on the living experiences inside restricted housing units, and practical/policy recommendations for improving prisoner, unit, and institutional safety.