cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IMPACT OF WHOLE EXOME SEQUENCING (WES) ON THE CLINICAL MANAGEMENT OF PATIENTS WITH ADVANCED NONALCOHOLIC FATTY LIVER (NAFL)
Creators: name: PELUSI, SERENA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Abstract Non-alcoholic fatty liver disease (NAFLD) is a potentially progressive disorder, possibily leading to cirrhosis and hepatocellular carcinoma (HCC). Both acquired and genetic risk factors play an important role in disease progression. In this respect, the presence of metabolic comorbidities such as obesity and type two diabetes mellitus has been associated to a more severe phenotype, while genetic factors modulating hepatic lipid metabolism such as the variants in PNPLA3 (patatin-like phospholipase domain-containing protein 3), TM6SF2 (transmembrane 6 superfamily member 2), MBOAT7 (membrane bound O-acyltranferase domain containing 7), GCKR (glucokinase regulatory protein) and APOB (apolipoprotein B) have been demostrated to influence disease predisposition. Secondly, a consistent fraction of patients with liver disorders are diagnosed at advanced stage and in approximately one third of cases it is not possible to establish an etiological diagnosis (cryptogenic cirrhosis). By exploiting Whole Exome Sequencing (WES) technology, in this work we aimed to: 1) identify the prevalence of known pathogenic mutations in candidate genes mutated in genetic liver diseases and hereditary cancer syndromes in patients with HCC and cirrhosis due to NAFLD or cryptogenic disease, to compare it to that of healthy individuals and to evaluate in the aforementioned genes the burden of rare or novel mutations of unknown significance, that determine an alteration of protein sequence, and are therefore likely pathogenic; 2) test the functional and clinical significance of the mutations identified, by bioinformatics algorithms and in vitro assays; 3) identify novel genetic risk factors predisposing to progressive NAFLD; 4) implement a genetic risk score (GRS) aiming to improve the stratification of the risk of progressive NAFLD; 5) test the impact of WES on the clinical management of six patients with cryptogenic liver disease. Briefly, we detected an enrichment in pathogenic (p = 0.024), and likely pathogenic variants (p = 1.9*10?6), particularly in APOB (p = 0.047). APOB variants were associated with lower circulating triglycerides and higher HDL cholesterol (p < 0.01). A genetic risk score predicted NAFLD-HCC (OR 4.96, 3.29?7.55; p = 5.1*10?16), outperforming the diagnostic accuracy of common genetic risk variants, and of clinical risk factors (p < 0.05). Furthermore, in one third of the six patients with cryptogenic liver disease and aggressive phenotype it was possible to identify a probable genetic disorder expleining the phenotype. In conclusion, rare pathogenic variants in genes involved in liver disease and cancer predisposition are associated with NAFLD-HCC development. Genetic study by WES can represent a precious instrument for risk stratification and allow a Precision Medicine approach in the context of liver disease aimed at the targeted treatment of the underlying cause of the disease.
Hidden magnetism uncovered in charge ordered bilayer kagome material ScV_6Sn_6
Creators: name: Guguchia, Z.
name: Gawryluk, D. J.
name: Shin, Soohyeon
name: Hao, Z.
name: Mielke, C.
name: Das, D.
name: Plokhikh, I.
name: Liborio, L.
name: Shenton, K.
name: Hu, Y.
name: Sazgari, V.
name: Medarde, M.
name: Deng, H.
name: Cai, Y.
name: Chen, C.
name: Jiang, Y.
name: Amato, A.
name: Shi, M.
name: Hasan, M. Z.
name: Yin, J. -X.
name: Khasanov, R.
name: Pomjakushina, E.
name: Luetkens, H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Charge ordered kagome lattices have been demonstrated to be intriguing platforms for studying the intertwining of topology, correlation, and magnetism. The recently discovered charge ordered kagome material ScV_6Sn_6 does not feature a magnetic groundstate or excitations, thus it is often regarded as a conventional paramagnet. Here, using advanced muon-spin rotation spectroscopy, we uncover an unexpected hidden magnetism of the charge order. We observe a striking enhancement of the internal field width sensed by the muon ensemble, which takes place within the charge ordered state. More remarkably, the muon spin relaxation rate below the charge ordering temperature is substantially enhanced by applying an external magnetic field. Taken together with the hidden magnetism found in AV_3Sb_5 (A = K, Rb, Cs) and FeGe kagome systems, our results suggest ubiqitous time-reversal symmetry-breaking in charge ordered kagome lattices.
description: 9 pages, 4 figures
Two-dimensional Lattice Gauge Theories with Superconducting Quantum Circuits
Creators: name: Marcos, D.
name: Widmer, P.
name: Rico, E.
name: Hafezi, M.
name: Rabl, P.
name: Wiese, U. -J.
name: Zoller, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A quantum simulator of U(1) lattice gauge theories can be implemented with superconducting circuits. This allows the investigation of confined and deconfined phases in quantum link models, and of valence bond solid and spin liquid phases in quantum dimer models. Fractionalized confining strings and the real-time dynamics of quantum phase transitions are accessible as well. Here we show how state-of-the-art superconducting technology allows us to simulate these phenomena in relatively small circuit lattices. By exploiting the strong non-linear couplings between quantized excitations emerging when superconducting qubits are coupled, we show how to engineer gauge invariant Hamiltonians, including ring-exchange and four-body Ising interactions. We demonstrate that, despite decoherence and disorder effects, minimal circuit instances allow us to investigate properties such as the dynamics of electric flux strings, signaling confinement in gauge invariant field theories. The experimental realization of these models in larger superconducting circuits could address open questions beyond current computational capability.
description: Published version
ESSAYS ON POPULATION, HUMAN CAPITAL AND ECONOMIC GROWTH
Creators: name: ERAYDIN, LEVENT
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: This thesis is composed by three independent chapters: two of them are original research papers, and one of them is a review-paper. Their common feature is represented by the ?unit of analysis?: namely the economic (growth) impact of population under endogenous choices of human capital investment by agents. The first paper is a survey article that mainly reviews the literatures of international migration and economic growth. The main motivation is to identify how and to what extent migration affects human capital accumulation, and thus, economic growth. The paper reveals that the research on migration requires a multi-dimensional perspective in explaining the human capital related economic questions and shows that that the impact of migration on human capital accumulation can be observed via three channels: The impacts of migration on (i) skill formation, (ii) fertility decisions and (iii) wage (income) levels. This review addresses that the changes in those factors generally drive many of the differences in results (either positive or negative or neutral) across studies. The second paper provides a complementary dimension to the directed technological change literature by introducing the human capital accumulation and migration to an Acemoglu-type growth model. The motivation behind this study is the lack of economic analyses on how skill-biased technological change (SBTC) affects the human capital accumulation in both sending and receiving countries under migration. The main results show that, while a SBTC in a technologically advanced country has positive effects on human capital accumulation in technologically less developed countries via migration, it may adversely affect the incentives of local (natives) low skilled individuals to invest in education at advanced countries. Therefore, the net effect of SBTC is ambiguous (either positive or negative or neutral) in developed countries under migration. The last paper analyzes the impact of population growth on economic growth under endogenous technological change and human capital investment. The novelty of this chapter is the inclusion of a ?dilution effect? of population growth on per capita human capital accumulation, which is not present in the original Uzawa-Lucas model. This study has showed that an increase in the population growth rate yields an ambiguous impact on the growth rate of per-capita income due to the relative contribution of two distinct effects of population growth: The direct dilution effect and the indirect ideas effect. This study revealed that the dilution effect has a central role in explaining the ambiguous impact of population growth on economic growth. Another result is that more population growth generates an indirect ideas effect on the rate of innovation and economic growth. These evidences are empirically checked for the advanced countries.
Влияние массы поросят при рождении на их рост, развитие и сохранность в подсосный период
Creators: name: Сайфутдинов М.Р.
name: Файзуллин Р.А.
Publisher: name: Владимирский земледелец
Year: 2018
Subjects: КРУПНАЯ БЕЛАЯ ПОРОДА
ПОДСОСНЫЕ ПОРОСЯТА
КОЛИЧЕСТВО ПОРОСЯТ ПРИ РОЖДЕНИИ
РАЗВИТИЕ
СОХРАННОСТЬ ПОРОСЯТ

description: На базе ООО «Зуринский Агрокомплекс» Удмуртской Республики было изучено влияния массы поросят крупной белой породы при рождении на их рост, развитие и сохранность. Изучение роста и развития животных в подсосный период проводили путем их взвешивания при рождении, в 20 дней, в 40 дней и при отъеме в 2 месяца. С учетом живой массы при рождении, были сформированы три группы поросят. Особи 2-ой и 3-ей групп с живой массой при рождении 1,28 ± 0,005 кг и 1,51 ± 0,03 кг развивались лучше мелкоплодных сверстников с живой массой при рождении 1,16 ± 0,005 кг. При этом поросята-сосуны 2-ой и 3-ей групп, достоверно превосходили сверстников 1-ой группы по живой массе при рождении на 0,12-0,35 кг (P> 0,999), в 20 днейна 0,51-1,25 кг (P> 0,999), в 40 дней на 0,68-1,95 кг и в 2 месяца на 0,86-2,64 кг (P> 0,999). Превосходство 2-ой и 3-ей групп над 1-ой по сохранности составило 9,79 % (P> 0,999) и 6,92 % (P> 0,90) соответственно.
Strong-coupling ansatz for the one-dimensional Fermi gas in a harmonic potential
Creators: name: Levinsen, Jesper
name: Massignan, Pietro
name: Bruun, Georg M.
name: Parish, Meera M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A major challenge in modern physics is to accurately describe strongly interacting quantum many-body systems. One-dimensional systems provide fundamental insights since they are often amenable to exact methods. However, no exact solution is known for the experimentally relevant case of external confinement. Here, we propose a powerful ansatz for the one-dimensional Fermi gas in a harmonic potential near the limit of infinite short-range repulsion. For the case of a single impurity in a Fermi sea, we show that our ansatz is indistinguishable from numerically exact results in both the few- and many-body limits. We furthermore derive an effective Heisenberg spin-chain model corresponding to our ansatz, valid for any spin-mixture, within which we obtain the impurity eigenstates analytically. In particular, the classical Pascal's triangle emerges in the expression for the ground-state wavefunction. As well as providing an important benchmark for strongly correlated physics, our results are relevant for emerging quantum technologies, where a precise knowledge of one-dimensional quantum states is paramount.
description: 13 pages, 6 figures. Published version
The Landscape of the Neutrino Mechanism of Core-Collapse Supernovae: Neutron Star and Black Hole Mass Functions, Explosion Energies and Nickel Yields
Creators: name: Pejcha, Ondrej
name: Thompson, Todd A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: If the neutrino luminosity from the proto-neutron star formed during a massive star core collapse exceeds a critical threshold, a supernova (SN) results. Using spherical quasi-static evolutionary sequences for hundreds of progenitors over a range of metallicities, we study how the explosion threshold maps onto observables, including the fraction of successful explosions, the neutron star (NS) and black hole (BH) mass functions, the explosion energies (E_SN) and nickel yields (M_Ni), and their mutual correlations. Successful explosions are intertwined with failures in a complex pattern that is not simply related to initial progenitor mass or compactness. We predict that progenitors with initial masses of 15 +/- 1, 19 +/- 1, and 21-26 M_Sun are most likely to form BHs, that the BH formation probability is non-zero at solar-metallicity and increases significantly at low metallicity, and that low luminosity, low Ni-yield SNe come from progenitors close to success/failure interfaces. We qualitatively reproduce the observed E_SN-M_Ni correlation, we predict a correlation between the mean and width of the NS mass and E_SN distributions, and that the means of the NS and BH mass distributions are correlated. We show that the observed mean NS mass of ~1.33 M_Sun implies that the successful explosion fraction is higher than 0.35. Overall, we show that the neutrino mechanism can in principle explain the observed properties of SNe and their compact objects. We argue that the rugged landscape of progenitors and outcomes mandates that SN theory should focus on reproducing the wide ranging distributions of observed SN properties.
description: 28 pages, 29 figures, 2 tables, accepted to ApJ. Our results are available at http://www.astro.princeton.edu/~pejcha/synth_sne/
OPPORTUNITIES FOR ORGANIC MARKET DEVELOPMENT IN PORTUGAL
Creators: name: CRISOSTOMO, CATARINA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: This study applies the theory of planned behaviour (TPB) to examine Portuguese consumers? purchasing behaviour with regard to certified organic food products. Drawing on survey and focus group data, consumers? attitudes are found to play a determinant role in purchase decisions, namely, to the extent that their beliefs about the consequences of purchasing organic food are grounded in product knowledge and experience. Perceived behavioural control and subjective norms also exert a significant, although smaller, influence on consumers? purchase intentions. An extended version of the TPB, including personal norms as an additional predictor of purchase intention, is also tested but there is no evidence to support an independent role of moral considerations in this context. Still, results suggest that the attainment of one?s personal values is inextricably linked to the most strong and stable favourable attitudes towards purchasing certified organic food. Practical implications of research findings are offered for all who have an interest in enhancing the market share of organic food products.
Constraints on parity and Lorentz violations in gravity from GWTC-3 through a parametrization of modified gravitational wave propagations
Creators: name: Zhu, Tao
name: Zhao, Wen
name: Yan, Jian-Ming
name: Wang, Yuan-Zhu
name: Gong, Cheng
name: Wang, Anzhong
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gravitational wave (GW) observations provide sensitive tests of parity and Lorentz symmetries of gravity. Any violation of these fundamental symmetries induces possible deviations in the GW propagations. Through a systematic parametrization for characterizing possible derivations from GW propagations in general relativity, we construct the modified GW waveforms generated by the coalescence of compact binaries with the effects of the parity and Lorentz violations as predicted by many parity- and Lorentz-violating gravities and then analyze them with the open data of compact binary merging events detected by LIGO-Virgo-KAGRA Collaboration. No signature of gravitational parity and Lorentz violations are found for most GW events, thereby allowing us to place several of the most stringent constraints on parity and Lorentz violations in gravity and a first constraint on the Lorentz-violating damping effect in GW.
description: 6 pages, 3 tables, and 1 figure; v2: 11 pages, 3 figures, 5 tables, version published in PRD
Additional file 2 of Elucidating the cellular response of silver nanoparticles as a potential combinatorial agent for cisplatin chemotherapy
Creators: name: Miranda, Renata Rank
name: Micaella Pereira Da Fonseca
name: Korzeniowska, Barbara
name: Skytte, Lilian
name: Rasmussen, Kaare Lund
name: Kjeldsen, Frank
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Additional file 2. List of proteins deregulated in HepG2 cells after 24 h exposure to AgNP, CDDP and AgNP/CDDP.
Kompetenzzentrum Forschungsdaten an der Universität Bielefeld - Poster
Creators: name: Vompras, Johanna
Publisher: name: Bielefeld University
Year: 2018
Subjects: subject: 020
subject: Forschungsdatenmanagement
subject: Kompetenzzentrum Forschungsdaten
subject: Data Science
subject: Forschungsunterstützung

description: Dieses Poster wurde an dem Bielefelder Data Science Day (23.05.2018) präsentiert. Es diente vor allem als Blickfang zum Thema Forschungsdatenmanagement an der Universität Bielefeld und zur Bekanntmachung des neu gegründeten Kompetenzzentrums. Das Poster kann/soll beliebig zu Werbe- und Informationszwecken, bei denen es darauf ankommt, die Supportdienstleistungen des Kompetenzzentrums prominent ins Licht zu rücken (z.B. bei Begehungen der Sonderforschungsbereiche oder FDM-relevanten Fachtagungen), nachgenutzt werden.

 Das Poster kann/soll es im Sinne von Openness an der Universität nachgenutzt und verbreitet werden. Die digitale Version ist unter der Creative Commons Namensnennung 4.0 International Lizenz (CC-BY 4.0) über PUB veröffentlicht (Zitationsempfehlung s. unten, Stil: APA).
Universal phenomenology at critical exceptional points of nonequilibrium $O(N)$ models
Creators: name: Zelle, Carl Philipp
name: Daviet, Romain
name: Rosch, Achim
name: Diehl, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In thermal equilibrium the dynamics of phase transitions is largely controlled by fluctuation-dissipation relations: On the one hand, friction suppresses fluctuations, while on the other hand the thermal noise is proportional to friction constants. Out of equilibrium, this balance dissolves and one can have situations where friction vanishes due to antidamping in the presence of a finite noise level. We study a wide class of $O(N)$ field theories where this situation is realized at a phase transition, which we identify as a critical exceptional point. In the ordered phase, antidamping induces a continuous limit cycle rotation of the order parameter with an enhanced number of $2N-3$ Goldstone modes. Close to the critical exceptional point, however, fluctuations diverge so strongly due to the suppression of friction that in dimensions $d<4$ they universally either destroy a preexisting static order, or give rise to a fluctuation-induced first order transition. This is demonstrated within a non-perturbative approach based on Dyson-Schwinger equations for $N=2$, and a generalization for arbitrary $N$, which can be solved exactly in the long wavelength limit. We show that in order to realize this physics it is not necessary to drive a system far out of equilibrium: Using the peculiar protection of Goldstone modes, the transition from an $xy$ magnet to a ferrimagnet is governed by an exceptional critical point once weakly perturbed away from thermal equilibrium.
Diffusion-induced dissipation and mode coupling in nanomechanical resonators
Creators: name: Edblom, Christin
name: Isacsson, Andreas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study a system consisting of a particle adsorbed on a carbon nanotube resonator. The particle is allowed to diffuse along the resonator, in order to enable study of e.g. room temperature mass sensing devices. The system is initialized in a state where only the fundamental vibration mode is excited, and the ring-down of the system is studied by numerically and analytically solving the stochastic equations of motion. We find two mechanisms of dissipation, induced by the diffusing adsorbate. First, short-time correlations between particle and resonator motions means that the net effect of the former on the latter does not average out, but instead causes dissipation of vibrational energy. For vibrational amplitudes that are much larger than the thermal energy this dissipation is linear; for small amplitudes the decay takes the same form as that of a nonlinearly damped oscillator. Second, the particle diffusion mediates a coupling between vibration modes, enabling energy transfer from the fundamental mode to excited modes, which rapidly reach thermal equilibrium.
description: 8 pages, 7 figures
LA SCIENZA TRA LIBERT� E POTERE: COSTITUZIONE E VALUTAZIONI TECNICO-SCIENTIFICHE
Creators: name: DEL CORONA, LAVINIA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Il presente lavoro analizza il rapporto, complesso e mutevole, sussistente tra scienza e potere politico al fine precipuo di verificare sotto quali aspetti e in che termini tale rapporto possa incidere sulla tutela dei diritti fondamentali. Il diritto, quale strumento tramite il quale le interazioni tra scienza e potere politico trovano disciplina e formalizzazione, assume a riguardo rilevanza centrale, tanto che i rapporti tra scienza e diritto possono dirsi ?specchio? dei rapporti sussistenti tra scienza e potere politico. In particolare, i rapporti tra scienza e potere politico sono strettamente correlati ad aspetti formali e procedurali ? dai rilevanti risvolti sostanziali ? come, in primo luogo, la ripartizione nell?ordinamento della competenza allo svolgimento di valutazioni tecnico-scientifiche e la determinazione delle modalit� in cui lo svolgimento di tali valutazioni � organizzato e disciplinato. Lo studio di tali profili � dunque centrale e necessario per individuare soluzioni in grado di garantire la massima tutela delle libert� e dei diritti fondamentali su cui la valutazione tecnico-scientifica pu� incidere. A tal fine, assumono grande rilevanza l?analisi del testo costituzionale e la ricerca in esso di indicazioni e principi che possano essere punto di riferimento per la disciplina di questioni tecnico-scientifiche. Nella prima parte del presente lavoro sono analizzati i concetti di norma tecnica, di valutazione tecnica, di discrezionalit� tecnica e opinabilit� scientifica nonch� le disposizioni che la Costituzione dedica alla scienza e la portata precettiva delle stesse. Nella seconda parte del lavoro � approfondito il rapporto tra scienza e potere legislativo. In particolare, si cerca di verificare, anche alla luce della giurisprudenza costituzionale sul tema, se e in che termini le caratteristiche proprie del sapere scientifico e l?esigenza di tutela dei diritti incisi dalle norme possono indurre a concludere che la scienza costituisce un limite alla discrezionalit� legislativa o, addirittura, a escludere l?opportunit� e la costituzionalit� di un intervento legislativo su questioni tecnico-scientifiche. Infine, nella terza parte del lavoro, l?attenzione � rivolta alla pubblica amministrazione e al procedimento amministrativo, al fine di verificare se la scientificit� delle questioni sottese alla scelta pubblica sia in grado di conferire un maggior rilievo al procedimento amministrativo come luogo di svolgimento della valutazione tecnica e se ci� possa essere considerato conforme alla Costituzione e utile per una massimizzazione della tutela dei diritti coinvolti.
Chiral and non-chiral swift mode conversion near an exception point with dynamic adiabaticity engineering
Creators: name: Wang, Dong
name: Huang, Wen-Xi
name: Zhou, Bo
name: Yu, Wenduo
name: Cao, Pei-Chao
name: Peng, Yu-Gui
name: Zhou, Zhengyang
name: Chen, Hongsheng
name: Zhu, Xue-Feng
name: Li, Ying
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The eigenvalue of a non-Hermitian Hamiltonian often forms a self-intersecting Riemann surface, leading to a unique mode conversion phenomenon when the Hamiltonian evolves along certain loop paths around an exceptional point (EP). However, two fundamental problems exist with the conventional scheme of EP encircling: the speed of mode conversion is restricted by the adiabatic requirement, and the chirality cannot be freely controlled. Here, we introduce a method which dynamically engineers the adiabaticity in the evolution of non-Hermitian Hamiltonians that allows for both chiral and non-chiral mode conversion on the same path. Our method is based on quantifying and controlling the instantaneous adiabaticity, allowing for non-uniform evolution throughout the entire path. We apply our method into the microwave waveguide system and by optimizing the distributed adiabaticity along the evolution loop, we achieve the same quality of mode conversion as conventional quasi-adiabatic evolution in only one-fourth of the time. Our approach provides a comprehensive and universal solution to address the speed and chirality challenges associated with EP encircling. It also facilitates the dynamic manipulation and regulation of non-adiabatic processes, thereby accelerating the operation and allowing for a selection among various mode conversion patterns.
title: Muskeln für das Gute
Creators: name: Lackner, Lucas
Year: 2021

description: Bei der vorliegenden Arbeit handelt es sich um eine sportethische Diskussion. Thema der Arbeit ist das Krafttraining im Breitensport aus der Sicht der Tugendethik. Das Krafttraining im Breitensport erfreut sich immer größerer Beliebtheit und nimmt immer größere Dimensionen an. Dabei stellt sich die Frage, ob es eine Grenze gibt, ab der das Krafttraining im Breitensport ethisch nicht mehr vertreten werden kann. Für die Beantwortung dieser Frage wurde der Standpunkt der Tugendethik gewählt. Die Tugendethik geht von der Haltung und Einstellung des Individuums aus. Weshalb sich letztlich die Frage gestellt werden muss, mit welcher Intention aus tugendethischer Sicht an das Krafttraining im Breitensport herangegangen werden sollte. Dafür werden zunächst die relevanten Begrifflichkeiten wie Sport, Ethik und Tugend erläutert. Danach werden die verschiedenen Einteilungsmöglichkeiten von Sport aufgezeigt, um das Krafttraining im Breitensport einordnen zu können. Zudem findet eine Abgrenzung zum klassischen Bodybuilding statt. Es erfolgt ein kurzer Überblick über die positiven Auswirkungen des Krafttrainings auf den menschlichen Körper. Es gibt verschiedene Motive und Gründe für das Krafttraining. Im freizeitlichen Krafttraining spielt vor allem das Motiv der Gesundheitsförderung und das ästhetische Motiv eine entscheidende Rolle. Diese beiden Motive werden von Personen, die ein Fitnessstudio besuchen, am häufigsten genannt. Dadurch dient das Krafttraining vielmehr als Mittel zum Zweck. Aus tugendethischer Sicht stellt sich die Frage, ob die Gesundheitsförderung und das Verändern der äußeren Erscheinung ein Endziel sind, oder nicht nur ein Zwischenziel sind und wiederum einem höheren Ziel dienen sollten. Aus dem Standpunkt der Tugendethik stellen beide Ziele im besten Fall ein Zwischenziel dar. Das Endziel ist die Glückseligkeit bzw. ein tugendhaftes Leben. Daher lohnt es sich diese beiden Ziele nur anzustreben, wenn sie zu einem tugendhaften Leben beitragen. Um jedoch das freizeitliche Krafttraining nicht zu voreilig zu beurteilen werden die positiven Aspekte des Krafttrainings aus ethischer Sicht aufgezeigt. Das Krafttraining kann ein Lehrer für das Leben sein, dabei ist die Haltung und der individuelle Stellenwert des Sports entscheidend.
title: Regulation of the Human Papillomavirus E7 Oncoprotein
Creators: name: Trejo Cerro, Oscar
Publisher: name: The Open University
Year: 2023

description: HPV-induced carcinogenesis is mainly associated with the uncontrolled expression of the oncoproteins E6 and E7. HPV E7 lacks enzymatic activity, however, it can target several cellular proteins to induce cell transformation and promote unregulated proliferation. Although numerous cellular target proteins have been reported to interact with the HPV E7 oncoprotein, the mechanisms involved in HPV-induced malignancy and the maintenance of cell transformation are still lacking. In this work, using a small HPV16 E7 peptide in a proteomic approach, we report Memo1 as a new E7 binding partner, interacting through the aspartic and glutamic acid residues (ED80-81) in the C-terminal region of HPV16 E7. The levels and localization of Memo1 in HPV-positive cell lines are regulated by HPV E7 and high expression of Memo1 correlates with reduced cell proliferation. In addition, we show that overexpression of Memo1 decreases HPV16 E7-induced transformation and is involved in the invasive capacity of transformed cells. Mechanistically, knock-down of Memo1 correlates with activation of the Akt pathway in HPV-positive cell lines, which seems to be regulated through a mechanism that is downstream of phosphatidylinositol 3-kinase (PI3K) activation. Although the E7-Memo1 interaction seems to be conserved across different HPV E7 types, including high and low-risk, we observed reduction of Memo1 levels only in the context of the high-risk HPV types. Our results show Memo1 as a new E7 binding partner and describe novel functions of Memo1 in the context of HPV-induced carcinogenesis.

 Furthermore, we found that the CKI and GSK3 kinases phosphorylate HPV16 E7 at threonine 5, 7 and 19-20 residues. The novel HPV16 E7 TT19-20 phosphorylation site seems to be important for E7-induced transformation and cell proliferation. Negative charges at this site enhance the binding of pRb to E7. Moreover, using a phosphorylated peptide of this region of HPV16 E7, we found new, potentially specific, phospho-E7 interactors. This data reveals novel phosphorylation sites in HPV16 E7, which modulate its interaction with pRb and might regulate the binding/function of other potential phospho-E7 interactors.
Strong decays of higher excited heavy-light mesons in a chiral quark model
Creators: name: Xiao, Li-Ye
name: Zhong, Xian-Hui
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The strong decay properties of the higher excited heavy-light mesons from the first radially excited states up to the first $F$-wave states are studied in a constituent quark model. It is found many missing excitations have good potentials to be found in future experiments for their narrow widths, some of them dominantly decay into the first orbital excitations rather than into ground states. In future observations, one should focus on the decay processes not only into the ground states, but also into the low-lying $P$-wave excitations with $J^P=0^+,1^+$. Furthermore, the nature of the newly observed states $D_J(3000)$, $D_J^*(3000)$ and B(5970) is discussed. It is predicted that $D_J(3000)$ seems to be a partner of $D_{sJ}(3040)$, which could be identified as the high-mass mixed state $|2{P_1}>_L$ ($J^P=1^+$) via the $2^1P_1$-$2^3P_1$ mixing. The $D_J^*(3000)$ resonance seems to favor the $1^3F_4$ state, however, the quantum numbers $J^P=0^+$ and $2^+$ can not be excluded complectly, more experimental observations are needed to determine its $J^P$ values. The B(5970) resonance is most likely to be the $1^3D_3$ with $J^P=3^-$.
description: 21 pages, 15 figures
Data Management Handbook Atlantos
Creators: name: Harscoat, Valerie
name: Pouliquen, Sylvie
name: Atlantos Wp7 Partners (Representatives Of Networks And Integrators),
Publisher: name: AtlantOS
Year: 2016

description: The H2020 AtlantOS project aims to optimize and enhance the Integrated Atlantic Ocean Observing System. One goal is to ensure that data from different and diverse in-situ observing Networks are readily accessible and useable to a wider community, including the international ocean science community and other stakeholders in this field. To achieve that, the strategy is to move towards an integrated data system within AtlantOS that harmonizes work flows, data processing and distribution across in-situ observing network systems, and integrates in-situ observations into existing European and international data infrastructures, termed Integrators (e.g. Copernicus INS TAC, SeaDataNet NODCs, EMODnet, EurOBIS, GEOSS). This handbook aims to help the Networks to implement recommendations agreed upon within AtlantOS WP7 to achieve a better integration of their data, and to provide best practices guidelines for both Networks and Integrators for enhanced services to users. First it presents the roadmap for the AtlantOS integrated system and its actors, both Networks and Integrators. Then the elements of (1) standardization across the Networks relying on existing European and international standards and protocols, and of (2) of the data exchange backbone of the AtlantOS system, are described with the guidelines on how to set them up. Finally this handbook describes ways to facilitate data discovery at the Network level and enhancements at the Integrator level for better fit-for-purpose services to users.
Critical behavior of AdS black holes surrounded by dark fluid with Chaplygin-like equation of state
Creators: name: Li, Xiang-Qian
name: Yan, Hao-Peng
name: Xing, Li-Li
name: Zhou, Shi-Wei
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Supposing the existence of Dark Fluid with a Chaplygin-like equation of state $p=-B/ρ$ (CDF) as a cosmic background, we obtain a static spherically-symmetric black hole (BH) solution to the Einstein gravitational equations. We study the $P-V$ critical behavior of AdS BH surrounded by the CDF in the extended phase space where the cosmological constant appears as pressure, and our results show the existence of the Van der Waals like small/large BH phase transition. Also, it is found that such a BH displays a first-order low/high-$Φ$ BH phase transition and admits the same criticality with van der Waals liquid/gas system in the non-extended phase space, where the normalization factor $q$ is considered as a thermodynamic variable, while the cosmological constant being fixed. In both $P-V$ and the newly proposed $q-Φ$ phase spaces, we calculate the BH equations of state and then numerically study the corresponding critical quantities. Moreover, the critical exponents are derived and the results show the universal class of the scaling behavior of thermodynamic quantities near criticality. Finally, we study the shadow thermodynamics of AdS BHs surrounded by the CDF. We find that, there exists a positive correlation between the shadow radius and the event horizon radius in our case. By analyzing the temperature and heat capacity curves under the shadow context, we discover that the shadow radius can replace the event horizon radius to demonstrate the BH phase transition process, and the changes of the shadow radius can serve as order parameters for the small/large BH phase transition, indicating that the shadow radius could give us a glimpse into the BH phase structure from the observational point of view.
description: 19 pages, 12 figures. PRD accepted version. arXiv admin note: text overlap with arXiv:2012.13271, arXiv:1407.0011 by other authors
Climate change assemblies as spaces for the potential mitigation of climate policy misperceptions: A survey experiment
Creators: name: Suiter, Jane
name: Saude, Kevin
name: McNally, Brenda
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 4407
subject: Policy and administration

description: Climate action stands as one of the paramount challenges in contemporary society. A significant impediment lies in the prevalence of misperceptions, notably the dissemination of narratives that either endorse climate policy delay or outright climate denial, often perpetuated by vested interests. The World Economic Forum, recognising the gravity of this issue, has underscored” misinformation and disinformation” as the preeminent global risk in the coming biennium, while the UN IPCC has stated that rampant disinformation is delaying climate action. Significantly, misinformation has been linked to climate misperceptions, for example, the belief in technological utopianism, for example, that climate change policies are ineffective and technological solutions will fix the problem in the future, which normalises acceptance of the status quo despite the urgent need for transformative actions. Recent scholarly literature posits that deliberative forums, commonly referred to as mini-publics, can contribute to mitigating such misperceptions while ensuring democratic legitimacy (Muradova et al. 2023) by informing the public. This paper contributes to the special issue on how Climate Change Assemblies (CAs) can contribute to reflexive environmental governance and help societies address the climate emergency, by exploring how CAs perform for the mitigation of climate policy misperceptions. In particular, we focus on whether communication about the procedural, aspects of citizen assemblies to the broader public emerges as a critical component. We understand these mechanisms to be contingent upon complex institutional dynamics, including mechanisms integral to their functioning such as the roles of representation, competence, and voice within assemblies. This empirical inquiry is situated within the framework of a survey experiment conducted across five European countries with varying climate policy salience and emissions levels. We find for most people reading about a climate citizens’ assembly makes little difference. We do find some minimal effects for the wider citizenry in general related to voice, although there are larger effects for some more sceptical cohorts, particularly for representation.
Additional file 3 of Walking cadence (steps/min) and intensity in 41 to 60-year-old adults: the CADENCE-adults study
Creators: name: Tudor-Locke, Catrine
name: Ducharme, Scott W.
name: Aguiar, Elroy J.
name: Schuna, John M.
name: Barreira, Tiago V.
name: Moore, Christopher C.
name: Chase, Colleen J.
name: Gould, Zachary R.
name: Amalbert-Birriel, Marcos A.
name: Mora-Gonzalez, Jose
name: Chipkin, Stuart R.
name: Staudenmayer, John
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 3. Table displaying a classification accuracy analysis for 125 steps/min as a candidate heuristic cadence threshold for 6 METs.
SeaDataNet. Second release of the aggregated data sets products
Creators: name: Simoncelli, Simona
name: Coatanoan, Christine
name: Myroshnychenko, Volodymyr
name: Sagen, Helge
name: Bäck, Örjan
name: Scory, Serge
name: Grandi, Alessandro
name: Schlitzer, Reiner
name: Fichaut, Michele
Publisher: name: SeaDataNet
Year: 2015

description: This document describes the V2 datasets per sea region (Mediterranean Sea, Black Sea, Arctic Sea, Baltic Sea, North Sea and the North Atlantic Ocean).
Structure and Osmotic Pressure of Ionic Microgel Dispersions
Creators: name: Hedrick, Mary M.
name: Chung, Jun Kyung
name: Denton, Alan R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate structural and thermodynamic properties of aqueous dispersions of ionic microgels -- soft colloidal gel particles that exhibit unusual phase behavior. Starting from a coarse-grained model of microgel macroions as charged spheres that are permeable to microions, we perform simulations and theoretical calculations using two complementary implementations of Poisson-Boltzmann (PB) theory. Within a one-component model, based on a linear-screening approximation for effective electrostatic pair interactions, we perform molecular dynamics simulations to compute macroion-macroion radial distribution functions, static structure factors, and macroion contributions to the osmotic pressure. For the same model, using a variational approximation for the free energy, we compute both macroion and microion contributions to the osmotic pressure. Within a spherical cell model, which neglects macroion correlations, we solve the nonlinear PB equation to compute microion distributions and osmotic pressures. By comparing the one-component and cell model implementations of PB theory, we demonstrate that the linear-screening approximation is valid for moderately charged microgels. By further comparing cell model predictions with simulation data for osmotic pressure, we chart the cell model's limits in predicting osmotic pressures of salty dispersions.
description: 14 pages, 10 figures
NOURDEM Seine : bilan de la campagne 2017
Creators: name: Le Goff, Ronan
name: Drogou, Mickael
name: Le Ru, Loic
name: Garren, Francois
name: Martin, Stephane
name: Bouche, Ludovic
name: Le Roy, Didier
name: Berthele, Olivier
Publisher: name: Ifremer
Year: 2017
Subjects: Bar européen, Dicentrarchus labrax
Nourricerie de l’estuaire de Seine
échantillonnage au chalut
Indice d’abondance 2017.
European Sea Bass
Dicentrarchux labrax
Nurserie of the Seine estuary
2017 Abundance index
trawling net samplings

description: Rapport de la campagne d’échantillonnage réalisée au moyen du chalut GOV « Bargip-NOURDEM » en août 2017 dans l’estuaire de la Seine afin d’y produire l’indice d’abondance 2017 en juvéniles de bar (et de quelques autres espèces d’intérêt commercial). Définition du plan d’échantillonnage applicable à l’avenir en cas de pérennisation d’une campagne annuelle.
Campagne réalisée dans le cadre d'un partenariat entre l'Ifremer, le Comité Régional des Pêches Maritimes de Normandie, le Comité Régional des Pêches Maritimes et Elevages Marins des Hauts de France, et les organisations de producteurs OP CME, OP Normandie, OP COBRENORD, OP FROM NORD et OP Pêcheurs de Bretagne.
Basic Physics Analyses Implemented Using Apache Spark
Creators: name: Canali, Luca
Publisher: name: Zenodo
Year: 2022

description: Apache Spark is a very successful open-source tool for data processing. This talk will focus on the use of Spark and its DataFrame API in the context of HEP. We will go through a few demos of some simple and outreach-style analyses implemented using Jupyter notebooks and the Spark Python API (PySpark). We will wrap up with a short discussion of the key features in Spark and its ecosystem that can be useful for Physics analysis and what still needs improvements.
Instanton Bags, High Density Holographic QCD and Chiral Symmetry Restoration
Creators: name: Bolognesi, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe the simplest example of an instanton bag in Euclidean space. It consists of a monopole wall and a Kaluza-Klein monopole wall, lifted to one higher dimension, trapping the instanton charge in the middle. This object has finite instanton density in a three-dimensional volume. Baryon physics in holographic QCD models gets translated into a multi-instanton problem in the bulk, and a state with a high density baryonic charge consists of a non-diluted multi-instanton solution. The instanton bag is a good candidate for this high-density state. We compute its parameters via moduli stabilization. Chiral symmetry restoration is exhibited by this state, and it is a direct consequence of its non-diluted features.
description: 32 pages, 11 figures; v2: revised version, accepted on prd
Superheavy dark matter and IceCube neutrino signals:bounds on decaying dark matter
Creators: name: Rott, Carsten
name: Kohri, Kazunori
name: Park, Seong Chan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Superheavy dark matter may show its presence in high energy neutrino signals detected on earth. From the latest results of IceCube, we could set the strongest lower bound on the lifetime of dark matter beyond 100 TeV around $10^{28} {\rm sec}$. The excess around a PeV is noticed and may be interpreted as the first signal of DM even though further confirmation and dedicated searches are invited.
description: 5 pages, 2 figures
Cosmological constraints on $R^2$-corrected Appleby-Battye model
Creators: name: Ribeiro, Bruno
name: Bernui, Armando
name: Campista, Marcela
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Nowadays, efforts are being devoted to the study of alternative cosmological scenarios in which modifications of General Relativity have been proposed to explain the late cosmic acceleration without assuming the existence of dark energy. In this scenario, we investigate the $R^2$-AB model, which consists of an $f(R)$ model with only one extra free parameter, $b$, in addition to the 6 of the flat-$Λ$CDM. Regarding this model, it was already shown that a positive value for $b$ is required for the model to be consistent with Solar System tests, moreover, the condition for the existence of a de~Sitter state requires $b \ge 1.6$. To impose observational constraints on the $R^2$-AB model we consider three datasets: 31 $H(z)$ measurements from Cosmic Chronometers (CC), 20 $[{fσ}_{8}](z)$ measurements from Redshift-Space Distortion (RSD), and the most recent type Ia Supernovae (SNe Ia) sample from Pantheon+. Next, we perform two different analyses: we have considered only SNe Ia data and the combined likelihood SNe+CC+RSD. The first one has provided $b=2.28^{+6.52}_{-0.55}$, while the second one $b=2.18^{+5.41}_{-0.55}$. In the first case it was necessary to set the absolute magnitude $M_B = -19.253$ from SH0ES collaboration, while in the second we did a marginalization over the Hubble constant $H_0$ in the normalized growth function. We have also observed that the $H_0-M_B$ degeneracy was broken by adding CC data to the SNe data. Additionally, we perform illustrative analyses that compare this $f(R)$ model with the flat-$Λ$CDM model, considering several values of the parameter $b$, for diverse cosmological functions like the Hubble function $H(z)$, the equation of state $w_{\rm eff}(z)$, the parametrized growth rate of cosmic structures $[fσ_8](z)$, and $σ_8(z)$. We conclude that the model fits well the data, but the parameter $b$ was not unambiguously constrained.