cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fiche d'inventaire - Objet n° 64SS30 (2/2) - Jarre à col roulé
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Grès

description: Source: FCA/3/2
description: Relation: Double de 64SS30 (1/2)
description: IIIF manifest
description: created: 1950/1970
Investigation of rapid evaporative ionisation mass spectrometry (REIMS) in minimally invasive surgery
Creators: name: Manoli, Eftychios
Publisher: name: Imperial College London
Year: 2022

description: Precision surgery requires technologies that can be used in-situ and can deliver real-time analysis of intra-operative pathology. Currently, surgical strategy is conceived using pre-operative imaging and visual assessment of anatomy intraoperatively, with postoperative histology guiding the necessity for any future intervention. This approach is often subjective, time-consuming, and costly. This project describes the validation of the Harmonic scalpel; an energy device commonly used in minimally invasive surgery, as a new surgical aerosol source for REIMS analysis. The generated surgical aerosol produced during the dissection of different porcine tissues was collected and analysed by REIMS, producing tissue-specific lipid profiles in positive and negative ionisation modes. Comparison with other surgical energy tools, such as monopolar electrosurgery and CO2 laser was made. Classification performance of the Harmonic-REIMS platform was assessed on different porcine tissue models showing 100% accuracy. To further understand how different technical and environmental conditions can impact the metabolic composition of colorectal mucosa tissue and affect REIMS spectra using the Harmonic device, a phantom environment was designed and developed. Real-time measurements of different conditions and spectral information were assessed, showing how REIMS is most likely to be impacted by changes in humidity, temperature, and presence of mucosal contamination, during the in vivo translation of the technology. Using the Harmonic-REIMS platform, a clinically annotated spectral database (n=286) was created ex vivo, including colorectal tissue from 23 patients. The diagnostic accuracy of REIMS in differentiating normal and tumour samples was assessed showing an overall diagnostic accuracy of 94%. Finally, as part of the translation of REIMS technology in minimally invasive surgery, in vivo human feasibility studies were made in laparoscopic and robotic surgery.
Exploring the impact of online networks available to BIPOC applicants of genetic counseling master’s programs
Creators: name: King, Destini
Publisher: name: No Publisher Supplied
Year: 2024

description: The genetic counseling field remains largely homogenous with 89% of practicing genetic counselors identifying as Non-Hispanic White (National Society of Genetic Counselors, 2023). Although there have been many diversity and recruitment initiatives, these efforts have not resulted in a notable change in demographics (Channaoui et al., 2020). A number of online networks have emerged with the mission of helping prospective students, including: Minority Genetic Professionals Network (MGPN), Genetics Opportunities, Learning, Development, and Empowerment Network (GOLDEN), Genetic Counseling Prospective Student Network (GCPSN), and GC Chat on Discord. Given the initiative to recruit and sustain more diversity in the field, a look into the utilization of these networks by Black, indigenous, and people of color (BIPOC) applicants is an important next step. The purpose of this study is to determine the extent to which BIPOC applicants are using online networks and the perceived impact of these networks. We found that common reasons for joining these online networks include needing help with applications and seeking connection to other BIPOC individuals. These networks may be offering those with limited connections and resources a way to get the exposure and experience they need to have a more competitive application. Mentors and genetic counselors are found to be major sources of support in the application process and these networks offer an avenue of connection. Overall, the utilization of these networks increased feelings of connection to the genetic counseling field, with networks aimed to support BIPOC applicants seeming to deepen that connection.
Neuroepithelial signalling of tactile stimulus in the human hair follicle
Creators: name: Agramunt, Julià
Publisher: name: Imperial College London
Year: 2022

description: Touch relies upon the most intimate of our senses. It enables us to feel our surroundings, to feel pleasure or pain and to interact with our loved ones. The hair follicle (HF) is an important mediator of touch perception innervated by low-threshold mechanoreceptors (LTMRs), a diverse group of tactile sensory neurons forming lanceolate and circumferential endings around the follicle. In this thesis I used a combination of immunofluorescent and microscopy approaches, combined with electroanalytical methods to evaluate the role of the HF epithelium in touch perception. I found that terminal human HFs are innervated by 5 different types of these neurons in the outer root sheath (ORS) where the HF epithelium has its stem cell niche. HF epithelial cells are capable to respond to tactile-like stimulus by activation of mechanosensitive ion channel, once activated, ORS cells are able to send signalling molecules such as ATP, serotonin and histamine to surrounding LTMRs. Using pharmacology to block specific histamine and serotonin receptors, LTMRs diminishes their response, suggesting that ORS cells can activate neurons using these neurotransmitters after tactile-like stimulus. Comparing to skin keratinocytes, both cell types can release histamine but interestingly, only ORS cells release serotonin. These results suggest that the HF epithelium is a special niche in the way it responds to tactile-like stimuli. Overall, these results are the first stone to investigate the relationship between ORS cells and LTMRs in touch perception.
Nanofabrication of semiconductor nanostructures for biological applications
Creators: name: Sun, Julia
Publisher: name: Imperial College London
Year: 2022

description: Advancements in nanotechnology have transformed our ability to characterize and manipulate biological systems and enabled significant progress in the studies of biology and medicine. An exciting area of growth is the development of strategies to non-destructively interface artificial materials with biological membranes, specifically with bioinspired technologies that mimic the endogenous membrane architecture. Previous work in developing biomimetic stealth probes has demonstrated the ability to recreate the plasma membrane’s hydrophilic-hydrophobic-hydrophilic architecture by self-assembling hydrophobic molecules onto a thin band of gold sandwiched between two layers of chromium. This unique interfacial architecture enabled the formation of high-strength interfaces between the probe and the plasma membrane. Building upon this work, this thesis aimed to create multilayered Au and Cr nanoparticles capable of spontaneous and non-destructive integration into cell membranes and function as inorganic gap junctions for cellular sensing, molecular drug delivery, and more. This thesis reports on the design and fabrication of doughnut-shaped Au and Cr nanoparticles measuring approximately 200 nm in diameter using electron beam lithography. By utilizing the dual-toned behavior of polymethyl methacrylate resists, sub-50 nm diameter centrally located holes spanning the full thickness of the nanoparticles were created. During nanoparticle release from the fabrication substrate, discovery of unexpected gold-catalyzed etching of silicon in fluorine-based plasma prompted investigation into the phenomenon termed ‘metal-assisted plasma etching (MAPE)’. Experiments systematically examined the effect of the catalyst architecture and the silicon substrate in MAPE and established a proposed mechanism for this interfacial-driven process. Lastly, colloidal patterning and nanoimprint lithography were explored as alternative fabrication methods for nanoparticle fabrication. The work presented in this thesis introduces the biomimetic nanoparticle as a novel platform technology and represents significant progress toward realizing full integration of artificial structures into biological membranes.
Regulation of adiposity in Drosophila
Creators: name: Vincent, Alec Jacques
Publisher: name: Imperial College London
Year: 2021

description: Obesity is a complex pathophysiology that is influenced by both cellular and systemic processes, highlighting the importance of in vivo experimental models to study the regulation of adiposity and obesity-associated diseases. Using the genetic tractability of Drosophila, I explore the role of the metabolite asymmetric dimethylarginine (ADMA) in the regulation of adiposity. ADMA levels were experimentally increased in vivo by genetically reducing its metabolic clearance by knocking-out dimethylarginine dimethylaminohydrolase (DDAH). DDAH knock-out animals (DDAHXP) display a range of metabolic phenotypes including a reduction in fat storage, increased mitochondrial content, elevated levels of respiration and altered sleep. Phenotypic differences between DDAHXP and an independently generated DDAH knock-out allele led me to identify an uncharacterised neighbouring gene as a novel putative regulator of adiposity. Knockdown of this gene was associated with downregulation of the aminotransferase dAGXT. In humans, AGXT deficiency is associated with primary hyperoxaluria type 1 (PH1), an autosomal recessive disorder of glyoxylate metabolism. Despite its relevance to human disease, AGXT is almost completely unstudied in Drosophila. I found that knockdown of dAGXT resulted in the formation of renal stones, recapitulating the major pathological feature of PH1. I identified previously uncharacterised short dAGXT transcripts that lack the sequence encoding its putative N-terminal mitochondrial targeting signal. I suggest that differential transcript choice, and hence organelle targeting, could underlie an important regulatory mechanism of metabolic activity. Of relevance, the most common mutations associated with PH1 cause mitochondrial mistargeting. Finally, I develop a model of obesity-associated nephrolithiasis and explore the underlying aetiology. Overall, work here highlights the usefulness of Drosophila as a model to study adiposity and obesity-associated disease.
Inteligencia Artificial en el proceso de investigación
Creators: name: Vázquez, Henry
name: Mendoza, Luz Omaira
Publisher: name: Universidad Alonso de Ojeda
Year: 2024

description: La inteligencia artificial puede colaborar con la episteme de la investigación de diversas maneras, tomando como criterio válido el poder profundizar con herramientas que colaboren en el procesamiento de lenguaje natural, para identificar y clasificar documentos relevantes, permitiendo a los investigadores procesar de manera más rápida; así como, precisar las evidencias científicas pertinentes a sus investigaciones.
Phyllogonostreptus silvestris Demange 1970
Creators: name: Golovatch, Sergei I.
name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Spirostreptida
Harpagophoridae
Phyllogonostreptus
Phyllogonostreptus silvestris

description: Phyllogonostreptus silvestris Demange, 1970
Phyllogonostreptus silvestris Demange, 1970: 80 (D). India, Madhya-Pradesh, Muki-Balaghat. Phyllogonostreptus silvestris — Demange, 1975: 161 (D); Bano, 1998b: 186 (M); Jeekel, 2006: 31 (M).
description: Published as part of Golovatch, Sergei I. & Wesener, Thomas, 2016, A species checklist of the millipedes (Myriapoda, Diplopoda) of India, pp. 1-75 in Zootaxa 4129 (1) on page 29, DOI: 10.11646/zootaxa.4129.1.1, http://zenodo.org/record/257571
Fiche d'inventaire - Objet n° 2358
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 901 - Fragment de couvercle
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Deep Learning for Climate Change Impact Assessment: Analyzing Satellite Imagery and Climate Models for Environmental Monitoring
Creators: name: Billah, Muhammad Maruf
name: Rakib, Abdullah Al
name: Md Imamul, Haque
name: Ahamed, Asif Shakil
name: Sharker, Diponkar
Publisher: name: Zenodo
Year: 2024

description: Climate change, driven by the emission of heat-trapping gases, poses significant challenges to global ecosystems and biodiversity. The Intergovernmental Panel on Climate Change (IPCC) aims to equip governments with the scientific knowledge needed to address these changes effectively. The rise in global temperatures, attributed to human activities such as deforestation and the emission of greenhouse gases, has led to more frequent and severe climate-related events. Climate change threatens to raise global sea levels, affect freshwater availability, and displace millions of people, necessitating coordinated global efforts like the Paris Agreement to mitigate its impacts.

Environmental monitoring is crucial in understanding and managing climate change. The use of satellite imagery and Earth observation data allows for the collection of comprehensive, high-resolution data essential for informed decision-making and policy development. These technologies enable the monitoring of critical Earth systems, including temperature variations, snow and ice cover, and vegetation health. Satellite imagery, processed through advanced machine learning algorithms, provides detailed analyses of land surface changes, aiding in climate change impact assessments.

Climate models play a pivotal role in environmental assessment, simulating the interactions within Earth's climate system to predict future conditions. These models, ranging from simple statistical tools to complex general circulation models, help forecast changes in weather patterns, water cycles, and ecosystem dynamics. The integration of deep learning techniques in climate change research enhances the accuracy and efficiency of these models, offering new insights into the potential impacts on agriculture, infrastructure, and human settlements. Effective environmental monitoring and robust climate models are essential for developing strategies to mitigate and adapt to climate change, ensuring sustainable progress and resilience for future generations.
Fiche d'inventaire - Objet n° 2808 - Fond fragmentaire de boîte
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 891 - Fond de boîte plate
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Spirostreptus
Creators: name: Golovatch, Sergei I.
name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Spirostreptida
Spirostreptidae
Spirostreptus

description: “ Spirostreptus ” asthenes Pocock, 1892
Spirostreptus asthenes Pocock, 1892: 137, 161 (D). India, Madras; Agarkovil Hills near Madurai; much of southern India.
Spirostreptus asthenes— Attems, 1914: 290 (M); 1936: 297 (M); Demange, 1961: 265 (M); Dwarakanath & Job, 1965a: 142, 143 (R); 1965b: 224 (M); 1974: 11 (M); Rajulu, 1970b: 142 (M); Chowdaiah & Kanaka, 1970: 41 (R) 1979: 17 (M); Subramoniam, 1971: 1296 (M); 1972: 200 (M); 1973: 250 (M); 1974a: 182 (M); 1974b: 200 (M); Dwarakanath, 1971: 351 (M); Dwarakanath et al., 1972: 185 (M); Kanaka & Chowdaiah, 1974: 261, 262 (M); Satyam & Ramamurthi, 1978: 325 (M); Rangaswamy et al., 1978c: 102 (R); 1983: 4 (M, R); Somasundaram & Chockalingam, 1981: 49 (R); Satyam et al., 1982: 913 (M); Bano, 1983: 169 (M); 1990: 2 (M); Achar, 1983a: 540, 541 (R); 1983b: 191 (M, R); 1987: 148, 150 (M); Nadarajalingam & Subramoniam, 1984: 229, 230 (R); 1987: 53, 54 (M); 1991: 8 (M); Prasath & Subramoniam, 1991: 865 (R); Reddy, 1991: 405 (R); Bai, 2001: 46, 51 (R); Jeekel, 2006: 46 (M); Reddy et al., 2007: 146 (M).
“ Spirostreptus ” asthenes — Bano, 1998b: 187 (M).
Remark: Since the original description mentions no male characters, the numerous subsequent records require verification.
description: Published as part of Golovatch, Sergei I. & Wesener, Thomas, 2016, A species checklist of the millipedes (Myriapoda, Diplopoda) of India, pp. 1-75 in Zootaxa 4129 (1) on page 29, DOI: 10.11646/zootaxa.4129.1.1, http://zenodo.org/record/257571
Fiche d'inventaire - Objet n° 1008 - Petite coupe
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 64SS382 (6/7) - Jarre
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre cuite

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 652 - Petit bol
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
中国西南地区肠道微生物多样性队列研究（人群遗传背景）
Creators: name: 钱, 晓波
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Genome sequencing
Multiisolate
Medical

description: 中国西南地区肠道微生物多样性队列研究（人群遗传背景）
Prognostic significance of Dickkopf-1 in head and neck squamous cell carcinoma
Creators: name: Chen, Kai
name: Li, Jin
name: Ouyang, Yanfeng
name: Xie, Yulong
name: Xu, Guiqiong
name: Xia, Tianliang
name: You, Rui
name: Liu, Guichao
name: He, Han
name: Huang, Rong
name: Chen, Mingyuan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Dickkopf-1 (DKK1) exhibits abnormal expression in various cancers and correlates with poor prognosis. This study investigates DKK1’s prognostic relevance in head and neck squamous cell carcinoma (HNSC). We conducted a comprehensive search across literature and sequencing databases to gather eligible studies and HNSC datasets. We calculated pooled standardized mean differences (SMD) and 95% confidence intervals (CI) for clinical characteristics, as well as hazard ratios (HR) with 95% CIs for overall survival (OS) and progression-free/disease-free survival (PFS/DFS). Sensitivity analysis gauged result stability, and Egger’s test assessed publication bias. Pooled results indicated that HNSC patients with higher T-stage exhibited elevated DKK1 expression levels, and this elevated expression was associated with shorter OS and PFS/DFS. While sensitivity analysis identified some studies significantly affecting pooled results, most were unaffected, and no publication bias was detected. DKK1 holds promise as a potential biomarker for predicting poor prognosis in HNSC patients, but further research is needed for confirmation.
Alpine oak genome
Creators: name: 杜芳(Fang K. Du)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Raw sequence reads
Monoisolate
Evolution

description: Q.aquifolioides, is endemic but widely distributed in the Himalaya–Hengduanshan biodiversity hotspot, and it occurs at the highest elevations, reaching the tree line in some areas. The species displays extreme environmental adaptations, including tolerance to cold dry environments, at an elevation ranging from 1,900 to 4,600 m a.s.l. Because of Q. aquifolioides widespread distribution and large ecological amplitude, its genome may provide useful insights into the genetic makeup and molecular mechanism behind the adaptation to high altitude environments.
Towards a Smarter Waste Management: Developing and Evaluating a Smart Waste Management Decision Support Framework
Creators: name: Sosunova, Inna
name: Happonen, Ari
name: Porras, Jari
name: Wolff, Annika
Publisher: name: Zenodo
Year: 2024

description: Appendix A - Context parameters of the city and WM system

Appendix B - The goals challenges and its KPIs

Appendix C - Evaluation and testing questionnaires
植物拟南芥愈伤组织再生
Creators: name: 李洁
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Transcriptome or Gene expression
Multiisolate

description: 植物器官从头再生是植物再生的重要方式之一。对芽从头再生机制认识的不足阻碍着众多植物遗传转化和离体组织培养技术的广泛应用1,2，对芽再生过程的解析对深入理解植物细胞全能性的基础和提高植物再生效率具有重要意义。芽的从头再生，依赖于对外植体诱导培养获得的愈伤组织。愈伤组织是一团具有较高分化再生能力的细胞，将愈伤组织转移到高细胞分裂素浓度的生芽培养基 (shoot-inducing medium, SIM) 上可经过重编程逐渐重新建立茎尖分生组织，再生获得芽器官3。在此过程中经历复杂的细胞命运转换和细胞重构4。
UMUMIY O'RTA TA'LIM MAKTABLARIDA FIZIKA TA'LIMNI    RIVOJLANTIRISHNING ASOSIY MUAMMOLARI
Creators: name: Ismoilov Sardorbek Bekmurod o'g'li Jizzах pоlitехnikа instituti Enеrgеtikа vа rаdiоelеktrоnikа fаkultеti"Fizikа" kаfеdrаsi asistenti
name: Ismoilova Muqaddas Bekmurod qizi O'zbekiston Milliy Unversiteti Biologiya fаkul`tеti Biotexnologiya (Tarmoqlari bo'yicha) 21.01 guruх tаlаbаsi
Publisher: name: Zenodo
Year: 2024

description: Mamlakatimizning  XXI asrdagi muvaffaqiyoti, tabiat resurslaridan samarali foydalanish, ekologik muammolarni yechish, kosmosni o‘zlashtirish, mudofa salohiyati, texnika va energetikaning rivojlanishi, fan manbalari uchun materiallar hamda zamonaviy texnologiyalarni yaratish kabi barcha yo‘nalishlar fizika fani va fizika ta’limi darajasiga bog‘liq.

Kalit so’zlar: Zamonaviy kompyuterlar, Internet tarmog‘i ta’limda fizikani o‘rganishda bir qator ijobiy xususiyatlarga ega dasturlari, kompyuterda namoyish etiladigan videolavhalar, avtomatlashtirilgan laboratoriya qurilmalari  va boshqalar uzluksiz ta’lim tizimida fizika fanini o‘qitishni zamonaviy darajasini oshiradi.
Towards a Smarter Waste Management: Developing and Evaluating a Smart Waste Management Decision Support Framework
Creators: name: Sosunova, Inna
name: Happonen, Ari
name: Porras, Jari
name: Wolff, Annika
Publisher: name: Zenodo
Year: 2024

description: Appendix A - Context parameters of the city and WM system

Appendix B - The goals challenges and its KPIs

Appendix C - Demography of evaluation and testing participants

Appendix D - Evaluation and testing questionnaires
Fiche d'inventaire - Objet n° 64SS547 (5/8) - Fond de jarre
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: Relation: Voir 64SS547 (1/8)
description: IIIF manifest
description: created: 1950/1970
Efficacy and safety of neoadjuvant combination immunotherapy in surgically resectable malignant solid tumors: a systematic review and meta-analysis
Creators: name: Feng, Yuqian
name: Guo, Kaibo
name: Jin, Huimin
name: Jiang, Jing
name: Wang, Menglei
name: Lin, Shengyou
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Neoadjuvant immunotherapy has emerged as a prominent research focus recently. For potentially operable patients, neoadjuvant therapy serves as a primary method to reduce tumor load and facilitate surgical interventions. We retrieved articles from PubMed, Embase, Cochrane Library, American Society of Clinical Oncology, and European Society of Medical Oncology websites from inception to December 2023. Statistical analyses were performed using the R software. Primary outcomes assessed included major pathological response (MPR), pathological complete response (pCR), and treatment-related adverse events (trAEs). 29 studies encompassing 1163 patients were included. The MPR rate of neoadjuvant combination immunotherapy was 38% (95% confidence interval [CI]: 25%–52%), and the pCR rate was 33% (95%CI: 25%–42%). These values were significantly higher than those obtained with single agent immunotherapy (p < 0.001). The pooled incidence of overall trAEs was 83% (95%CI: 73%–92%), and grade (G) 3–4 trAEs was 22% (95%CI: 15%–29%), both significantly higher than those observed with single agent immunotherapy (p < 0.05). This study demonstrated the efficacy of neoadjuvant combination immunotherapy. Given that the majority of the included trials were phase II with small sample sizes, further multicenter phase III randomized controlled trials should be conducted to validate the findings of the review.
Efficacy of third-generation epidermal growth factor receptor-tyrosine kinase inhibitors in advanced NSCLC with different T790M statuses tested via digital droplet polymerase chain reaction ddPCR and next-generation sequencing
Creators: name: Xu, Ziyi
name: Li, Yan
name: Wang, Lin
name: Hao, Xuezhi
name: Ying, Jianming
name: Li, Junling
name: Xing, Puyuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: We hypothesize that digital droplet polymerase chain reaction (ddPCR) would optimize the treatment strategies in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) relapsed patients. In this study, we compared the efficacy of third-generation TKIs with various T790M statuses via ddPCR and next-generation sequencing (NGS). NGS was performed on blood samples of patients progressed from previous EGFR-TKIs for resistance mechanism. T790M-negative patients received further liquid biopsy using ddPCR for T790M detection. A cohort of 40 patients were enrolled, with 30.0% (12/40) T790M-positive via NGS (Group A). In another 28 T790M-negative patients by NGS, 11 (39.3%) were T790M-positive (Group B) and 17 (60.7%) were T790M-negative (Group C) via ddPCR. A relatively longer progression-free survival (PFS) was observed in group A (NR) and group B (10.0 months, 95% CI 7.040–12.889) than in group C (7.0 months, 95% CI 0.000–15.219), with no significant difference across all three groups (p = 0.196), or between group B and C (p = 0.412). EGFR-sensitive mutation correlated with inferior PFS (p = 0.041) and ORR (p = 0.326), and a significantly lower DCR (p = 0.033) in T790M-negative patients via NGS (n = 28). This study indicates that ddPCR may contribute as a supplement to NGS in liquid biopsies for T790M detection in EGFR-TKIs relapsed patients and help to optimize the treatment strategies, especially for those without coexistence of EGFR-sensitive mutation. www.clinicaltrials.gov identifier is NCT05458726.
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes
Creators: name: 张方亮(Fangliang Zhang)
Publisher: name: CNGB
Year: 2024
Subjects: Transcriptome or Gene expression
Monoisolate
Medical

description: MDSSRP95H+DoxDMSO-2-SP2104010565
MDSSRP95H+DoxDMSO-3-SP2104010564
MDSSRP95H+Doxtala-1-SP2104010560
MDSSRP95H+Doxtala-2-SP2104010558
MDSSRP95H+Doxtala-3-SP2104010559
MDSSRP95H-DoxDMSO-1-SP2104010569
MDSSRP95H-DoxDMSO-2-SP2104010567
MDSSRP95H-DoxDMSO-3-SP2104010568
MDSSRP95H-Doxtala-1-SP2104010561
MDSSRP95H-Doxtala-2-SP2104010562
MDSSRP95H-Doxtala-3-SP2104010563
title: Universitätsbibliothek Marburg Ms. or. 41: [Mahmud Han bin Mustafa el-muzaffer dâimâ, Erlass]
Creators: name: Mahmud I., Osmanisches Reich, Sultan
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Manuscripts & rare books
Handschriften, seltene Bücher

description: Elektronische Reproduktion von: [Handschrift] Universitätsbibliothek Marburg Ms. or. 41: [Mahmud Han bin Mustafa el-muzaffer dâimâ, Erlass]. - Konstantinopel, 1143/1722. - 1 Blatt. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: Ms. or. 41. - 
Bemerkungen: In arabischer Schrift, osmanisch. - 
Digitalisiert 2024
Multi-omics analysis identifies multilevel predictors and therapeutic targets of MTX in psoriasis
Creators: name: 尚潇潇(SHANGXIAOXIAO)
Publisher: name: CNGB
Year: 2024
Subjects: Metagenome
Environment
Medical

description: We collected biological samples at different time points during a clinical trial and analyzed these samples with a multi-omics approach, using cytometry of time of flight (CyTOF), luminex, metabolomics, and metagenomics. In general, we observed significant imbalances in the ratio of T cells versus myeloid cells and CD4 and CD8 double negative T cells (DNT) versus gamma-delta-T cells in the peripheral blood of psoriasis patients. When discriminating between good (GR) and poor responders (PR) towards MTX treatment, we observed a more pronounced immune cell disbalance in the GR group of patients compared to the PR group. The complexity and diversity of the immune cell network of psoriasis patients decreased remarkably, but partially restored to a network similar to healthy individuals after treatment in GR. Our multi-omics approach identified potential predictors of immune cell subsets, serum metabolites, and gut microbiota of the MTX response, and we constructed related prediction models. Several immune cell subsets changed upon MTX treatment and are therefore defined as potential targets of MTX. The regulation of these targets was specifically linked to alterations of immune molecules, serum metabolites, and gut microbiota. Of note, the PDL1+NK cells subset, which was identified as a target of MTX as well as a potential indicator for psoriasis relapse, appears strongly linked to the level of various serum metabolites. Among these metabolites, 2,3-Dinor,6-keto-PGF1alpha, likely serves as critical linchpin and can contribute to the impact of the gut microbiome and the immune cell subsets on the proportional change of PDL1+NK cells. Our findings provide valuable insights for improving the precision of MTX treatment and understanding its immune regulatory mechanisms.
Fiche d'inventaire - Objet n° 64SS42 (3/4) - Fond de boîte
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
A rapid and versatile genome-wide evolutionary engineering approach for developing robust and productive industrial yeast
Creators: name: 王云(Yun Wang)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Raw sequence reads
Transcriptome or Gene expression
Monoisolate
Industrial

description: Developing more robust and productive industrial yeast is crucial for high-efficient bio-manufacture, However, the challenges posed by time consumption and abundance of mutations generated through genome-wide evolutionary engineering hinder the optimization of host systems for industrial applications. To address these challenges, we present a novel solution called Genome-wide Evolution based CRISPR/Cas with Donor-free (GEbCD) system. The system combines targeted sgRNAs and multiple environmental stresses to rapidly evolute millions mutant phenotypes in several rounds of iterative evolution based hypermutation. Using the GEbCD approach, we obtained an industrial Saccharomyces cerevisiae SISc-rad52-G4-72 (G4-72) with significant robustness and productivity within three weeks. The pilot scale fermentation of G4-72 in industry showed that under the multiple stresses of high solid content liquefied mash, the maximum fermentation temperature was increased by 8 degrees Celsius, and ethanol production was increased by 7.9%, with excellent robustness. Overall, the GEbCD system presents a powerful tool for effectively generating mutant library and rapidly improving productivity and multiple tolerance of industrial strains, offers a novel strategy for optimizing microbial chassis cell regarding various demands in industrial applications.
Novel early warning technique for colorectal cancer based on 16S gut microbes
Creators: name: 韩书文(Han Shuwen)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multispecies
Medical

description: This project takes the key population of colorectal cancer in 8 community hospitals of the urban medical consortium led by the applicant unit (covering all central urban areas) as the research object. It intends to screen out the high-risk population of colorectal cancer through questionnaire survey and fecal occult blood test. Stool samples before the first colonoscopy were collected from all high-risk groups and stored to provide technical support for the screening of gut microbes for the early warning of colorectal cancer.
Spirostreptus
Creators: name: Golovatch, Sergei I.
name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Spirostreptida
Spirostreptidae
Spirostreptus

description: “ Spirostreptus ” cinctatus Newport, 1844
Spirostreptus cinctatus Newport, 1844a: 270 (D). India, Madras.
Spirostreptus cinctatus — Newport, 1844b: 14 (M); Preudhomme de Borre, 1884b: 65 (M); Pocock, 1892: 136 (M); Attems, 1914: 290 (M); 1936: 298 (M); Demange, 1961: 265 (M); Rajulu, 1970b: 142 (M). Iulus (sic!) cinctatus — Gervais, 1847: 164 (D).
“ Spirostreptus ” cinctatus — Bano, 1998b: 187 (M).
Remark: All available descriptions mention no male characters.
description: Published as part of Golovatch, Sergei I. & Wesener, Thomas, 2016, A species checklist of the millipedes (Myriapoda, Diplopoda) of India, pp. 1-75 in Zootaxa 4129 (1) on page 29, DOI: 10.11646/zootaxa.4129.1.1, http://zenodo.org/record/257571
Decoding the cellular and molecular basis of cattle horn development from single-cell multi-omics data
Creators: name: 王禹(Yu Wang)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multiisolate
Agricultural

description: we applied single-nucleus multiomics and spatial methods, integrating 4 snRNA-seq, 4 snATAC-seq and one spatial transcriptional data of horn bud and adjacent frontal skin as well as 77 bulk transcriptomes of multiple tissues (including 20 horn bud samples on different fetal stages and frontal skin, heart, liver, spleen, lung, kidney, brain, rumen and skeletal muscle) to characterize horn morphogenesis through time.
Plasma-derived exosomal miRNAs profiles in Postmenopausal osteoporosis
Creators: name: 高攀(Pan Gao)
Publisher: name: CNGB
Year: 2024
Subjects: Transcriptome or Gene expression
Multiisolate
Medical

description: The plasma-derived exosomes from 272 postmenopausal women ( including 60 postmenopausal osteoporosis, 52 healthy controls and 160 osteopenia ) were sampled for miRNA sequencing, and then portray transcriptiome profiles using systematic analysis.
Fiche d'inventaire - Objet n° 705 - Fond de coupe
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
SHARQ MUTAFAKKIRLARI ASARLARIDA O'QITUVCHI VA MURABBIYLARNING O'RNI
Creators: name: Saffarova, Mohidil
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada sharq mutafakkirlarining va pedagoglarining o‘qituvchi va murabiylar haqidagi fikrlari o‘rganildi va tahlil qilindi.
Single-cell Transcriptome of Inactivated COVID-19 Vaccine PBMCs after 4 Month
Creators: name: 祝中一(ZhongYi Zhu)
Publisher: name: CNGB
Year: 2024
Subjects: Transcriptome or Gene expression
Multiisolate

description: This project involves single-cell transcriptome data from PBMCs of 27 healthy individuals four months after receiving the inactivated COVID-19 vaccine.
Microbial metagenomic sequencing data of pig faeces from smallholder and large-scale farming models
Creators: name: 文仁桥(Wen Renqiao)
Publisher: name: CNGB
Year: 2024
Subjects: Metagenome
Metagenomic assembly
Environment
Agricultural

description: The smallholder farming model is an important one and occupies a considerable share in many underdeveloped regions. We collected and analysed several faeces from pigs from smallholder farming as well as pigs from large-scale farming, and obtained their high-depth metagenomic sequencing data, which provides a basis for in-depth study of the faecal microbiome of pigs from smallholder farming models.
Whole genome sequence of Escherichia coli ESBL of porcine origin
Creators: name: 文仁桥(Wen Renqiao)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Monoisolate
Agricultural

description: Whole genome sequence of ESBL Escherichia coli isolated from Sichuan large-scale farms and smallholder farming pigs.
cfDNA end motif GWAS summary statistics
Creators: name: 李霖轩(Li Linxuan)
Publisher: name: CNGB
Year: 2024
Subjects: Variation
Targeted Locus (Loci)
Monoisolate
Medical

description: The GWAS results of 4-mer cfDNA (cell free DNA) end motifs in a dataset of 28,016 Chinese women.
Open Access Monitoring Brandenburg
Creators: name: Falkenburg, Philipp
name: Heinemann, Yan
name: Stadler, Heike
Publisher: name: Zenodo
Year: 2024
Subjects: Publikationsanalyse
BiblioCon
BiblioCon 2024
Open Access Monitoring
Brandenburg
Kennzahlen
Report

description: Das Poster präsentiert das Open Access Monitoring Brandenburg (OAMBB) als einen methodologisch neuen Ansatz für ein landesbezogenes Monitoring von Open-Access-Aktivitäten. Das Verfahren ist partizipativ ausgerichtet und bildet den Open-Access-Status an den Hochschulen des Landes Brandenburg anhand bestimmter Kriterien wie dem Publikationsaufkommen, der Open-Access-Quote und Publikationskosten ab und betont in Wechselbeziehung zum Gesamtportfolio der Vernetzungs- und Kompetenzstelle Open Access Brandenburg Prinzipien wie Kompetenzstärkung, Bibliodiversität, Nachhaltigkeit und Partizipation. Dabei identifiziert der Ansatz zugleich eine Reihe von Herausforderungen, aus denen sich wiederum weiterführende methodische Anpassungen ergeben. Diese liegen in der Vielfalt der Wissenschafts- und Publikationskulturen, Hochschulstrukturen und Datenqualität der genutzten Quellen. Auf dem Poster präsentieren wir die Erkenntnisse (Best Practice, Lessons Learned) aus dem Prozess des Landesmonitorings für das Land Brandenburg sowie Entwicklungsmöglichkeiten des Ansatzes. Publikation des Berichts siehe https://doi.org/10.5281/zenodo.10666013
description: Gefördert mit Mitteln des Ministeriums für Wissenschaft, Forschung und Kultur des Landes Brandenburg.
Fiche d'inventaire - Objet n° 64SS536 (3/3) - Jarre à col
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: Relation: Suite de 64SS536 (1/3)
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 64SS94 (13/16) - Couvercle
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: Relation: Suite de 64SS94 (12/16)
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 281 - Fragments de coupe
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Spirostreptus
Creators: name: Golovatch, Sergei I.
name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Spirostreptida
Spirostreptidae
Spirostreptus

description: “ Spirostreptus ” jerdani Pocock, 1892
Spirostreptus jerdani Pocock, 1892: 137, 161 (D). India, Madras. Spirostreptus jerdani— Attems, 1936: 298 (M); Demange, 1961: 265 (M); Rajulu, 1970b: 142 (M); Jeekel, 2006: 49 (M).
Spirostreptus Jerdani (sic!)— Attems, 1914: 290 (M).
“ Spirostreptus ” jerdani— Bano, 1998b: 187 (M).
Remark: The original description mentions no male characters.
description: Published as part of Golovatch, Sergei I. & Wesener, Thomas, 2016, A species checklist of the millipedes (Myriapoda, Diplopoda) of India, pp. 1-75 in Zootaxa 4129 (1) on page 29, DOI: 10.11646/zootaxa.4129.1.1, http://zenodo.org/record/257571
Fiche d'inventaire - Objet n° 2862 - Coupelle fragmentaire à bords droits
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 619 - Creuset
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre cuite

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 64SS547 (7/8) - Creuset
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre cuite

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 2806 - Fragment de couvercle ? Coupe à bouton ?
Creators: name: Conservation D'Angkor
name: École Française D'Extrême-Orient
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre cuite

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 64SS64 (6/6) - Couvercle
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: Relation: Suite de 64SS64 (1/6)
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 968 - Fragment de céramique
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Terre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Target Identification
Creators: name: CD ComputaBio
Publisher: name: Zenodo
Year: 2024

description: Regular methods are based on high throughput omics-datasets, such as genome-wide association scans, gene expression analysis from tissue to a single cell, miRNA analysis, proteomics, metabolomics, post-translational modifications, cellular imaging, etc. Target-based and phenotypic screening are most commonly used approaches for finding and validating drug targets. Computational approaches offer novel testable hypotheses for systematic, unbiased identification of molecular targets of known drugs. With the rapid development of AI and machine learning technologies, unstructured information from omics, text and image analytics, public databases, systems biology can be integrated. Our expert team can help clients extracting knowledge from a multitude of resources and thus enabling science-based decisions.
Spirostreptus
Creators: name: Golovatch, Sergei I.
name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Spirostreptida
Spirostreptidae
Spirostreptus

description: “ Spirostreptus ” maculatus Newport, 1844
Spirostreptus maculatus Newport, 1844a: 270 (D). India, Calcutta (= Kolkata).
Spirostreptus maculatus — Newport, 1844b: 14 (M); Preudhomme de Borre, 1884b: 68 (M); Pocock, 1892: 136 (M); Attems, 1914: 290 (M); 1936: 298 (M); Demange, 1961: 265 (M); Rajulu, 1970b: 142 (M); Jeekel, 2006: 49 (M).
Iulus (sic!) maculatus — Gervais, 1847: 164 (D).
“ Spirostreptus ” maculatus — Bano, 1998b: 187 (M).
Remark: All available descriptions mention no male characters.
description: Published as part of Golovatch, Sergei I. & Wesener, Thomas, 2016, A species checklist of the millipedes (Myriapoda, Diplopoda) of India, pp. 1-75 in Zootaxa 4129 (1) on pages 29-30, DOI: 10.11646/zootaxa.4129.1.1, http://zenodo.org/record/257571
Soil Mapping is a Key component of Environmental Sustainability
Creators: name: R. Srinivasan1 and V. Kasthuri Thilagam2
Publisher: name: trends in Agriculture Science
Year: 2024

description: Soil is the loose surface material that covers most land. It consists of inorganic particles and organic matter. Soil provides the structural support for plants used in agriculture and is also their source of water and nutrients. Soils vary greatly in their chemical and physical properties. Processes such as leaching, weathering and microbial activity combine to make a whole range of different soil types. Each type has particular strengths and weaknesses for agricultural production.
BOSHLANG'ICH SINF TARBIYA DARSLARIDA MAISHIY KO'NIKMALARNI SHAKLLANTIRISH METODIKASI
Creators: name: Radjabova, Gulnoza
Publisher: name: Zenodo
Year: 2024

description: Maqolada boshlangʻich sinf tarbiya fani dars jarayonini tashkil etish usul vositalari haqida misollar keltirilgan. Didaktik vositalardan foydalanishda oʻquvchilarning psixologik, yosh xususiyatlarini inobatga olish zarurligi misollar asosida isbotlangan. Dars jarayonini tashkil etishning samarali usul va vositalari keltirilgan.
Fiche d'inventaire - Objet n° 23 - Fragment de couvercle de vase
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Porcelaine

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970