cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study
Creators: name: Fisser, Christoph
name: Winkler, Maren
name: Malfertheiner, Maximilian Valentin
name: Philipp, Alois
name: Foltan, Maik
name: Lunz, Dirk
name: Zeman, Florian
name: Maier, Lars S.
name: Lubnow, Matthias
name: Müller, Thomas
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ; ECMO; Anticoagulation; Argatroban; Heparin; Thrombosis; Bleeding; Costs
subject: 610 Medizin

description: Background During venovenous extracorporeal membrane oxygenation (vvECMO), direct thrombin inhibitors are considered by some potentially advantageous over unfractionated heparin (UFH). We tested the hypothesis that Argatroban is non-inferior to UFH regarding thrombosis and bleeding during vvECMO. Methods We conducted a propensity-score matched observational non-inferiority study of consecutive patients without heparin-induced-thrombocytopenia (HIT) on vvECMO, treated between January 2006 and March 2019 in the medical intensive care unit at the University Hospital Regensburg. Anticoagulation was realized with UFH until August 2017 and with Argatroban from September 2017 onwards. Target activated partial thromboplastin time was 50 +/- 5seconds in both groups. Primary composite endpoint was major thrombosis and/or major bleeding. Major bleeding was defined as a drop in hemoglobin of >= 2 g/dl/day or in transfusion of >= 2 packed red cells/24 h, or retroperitoneal, cerebral, or pulmonary bleeding. Major thrombosis was defined as obstruction of > 50% of the vessel lumen diameter by means of duplex sonography. We also assessed technical complications such as oxygenator defects or pump head thrombosis, the time-course of platelets, and the cost of anticoagulation (including HIT-testing). Results Out of 465 patients receiving UFH, 78 were matched to 39 patients receiving Argatroban. The primary endpoint occurred in 79% of patients in the Argatroban group and in 83% in the UFH group (non-inferiority for Argatroban, p = 0.026). The occurrence of technical complications was equally distributed (Argatroban 49% vs. UFH 42%, p = 0.511). The number of platelets was similar in both groups before ECMO therapy but lower in the UFH group after end of ECMO support (median [IQR]: 141 [104;198]/nl vs. 107 [54;171]/nl, p = 0.010). Anticoagulation costs per day of ECMO were higher in the Argatroban group (euro26 [13.8;53.0] vs. euro0.9 [0.5;1.5], p < 0.001) but not after accounting for blood products and HIT-testing (euro63 [42;171) vs. euro40 [17;158], p = 0.074). Conclusion In patients without HIT on vvECMO, Argatroban was non-inferior to UFH regarding bleeding and thrombosis. The occurrence of technical complications was similarly distributed. Argatroban may have less impact on platelet decrease during ECMO, but this finding needs further evaluation. Direct drug costs were higher for Argatroban but comparable to UFH after accounting for HIT-testing and transfusions.
Computer-Assisted Interpreting: Cognitive Task Analysis and Evidence-Informed Instructional Design Recommendations
Creators: name: Frittella, Francesca Maria
Publisher: name: University of Surrey
Year: 2024
Subjects: Four-Component Instructional Design
Cognitive Task Analysis
Educational Design Research
Computer-Assisted Interpreting

description: Computer-assisted interpreting (CAI)—the use of support tools powered by automatic speech recognition and artificial intelligence during simultaneous interpreting—may be regarded as the epitome of ‘skill of the future’ for interpreters. CAI tools bear the potential to increase output quality and productivity and help interpreters cope with the demands of a fast-changing and increasingly technologized profession. Despite a growing demand for CAI training, no research has been conducted to specify the necessary skills and instruction. The present dissertation aims to identify crucial CAI skills and develop research-based recommendations for the design of CAI training. A Cognitive Task Analysis (CTA) was conducted on data gathered in two empirical cycles exploring experienced simultaneous interpreters’ performance, behaviour, and perception in a CAI test. The key outcomes of the CTA are a model of the CAI task, an inventory of CAI skills specifying their cognitive nature, and the analysis of the knowledge and attitudes required to successfully acquire and perform those skills. Starting from CTA results, recommendations for CAI training were developed through the application of the Four-Component Instructional Design Model (4C/ID). The study informs CAI training practice, expands the current scientific understanding of this complex task, and provides methodological inputs for future educational research on interpreting technology and beyond.
Additional file 7: Figure S7. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors
Creators: name: Fang, Xiao-Qian
name: Qiao, Haifa
name: Groveman, Bradley
name: Feng, Shuang
name: Pflueger, Melissa
name: Wen-Kuan Xin
name: Ali, Mohammad
name: Shuang-Xiu Lin
name: Jindong Xu
name: Duclot, Florian
name: Kabbaj, Mohamed
name: Wang, Wei
name: Ding, Xin-Sheng
name: Santiago-Sim, Teresa
name: Jiang, Xing-Hong
name: Salter, Michael
name: Yu, Xian-Min
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Infection of PKD1 shRNA reduces PKD1 expression. (PDF 103 kb)
Additional file 11: Figure S7. of DNA microarray revealed and RNAi plants confirmed key genes conferring low Cd accumulation in barley grains
Creators: name: Hongyan Sun
name: Chen, Zhong-Hua
name: Chen, Fei
name: Lupeng Xie
name: Guoping Zhang
name: Vincze, Eva
name: Feibo Wu
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Integrated schematic of the mechanisms involved in Cd high accumulation and tolerance. (PDF 183 kb)
Trichopagurus trichophthalmus Forest 1954
Creators: name: Komai, Tomoyuki
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Paguridae
Trichopagurus
Trichopagurus trichophthalmus

description: Trichopagurus trichophthalmus (Forest, 1954)
Catapaguroides? trichophthalmus Forest, 1954: 74, figs. 20–24.
Trichopagurus trichophthalmus. — de Saint Laurent 1968: 927; 1970: 212, figs. 1–16. — Baba 1982: 68 (part). — Komai & Osawa 2005: 11, figs. 4–6. — McLaughlin et al. 2010: 36.
Material examined. Japan. Apo-gama Cave, Onna Village, Okinawa Island, 30 m, 13 April 2009, SCUBA diving, coll. Yusuke Yamada, 1 ovigerous female (sl 1.3 mm), CBM-ZC 9640.
Taiwan. Shangjianwan, Kenting, 3–8 m, fore reef of nearshore fringing reef, 29 October 2000, coll. Gustav Paulay, 1 ovigerous female (sl 1.8 mm), FMNH 3769.
Marianas. Camel Rock, Guam, 15 m, 8 May 2001, coll. R. Riston-Williams, 1 female (sl 1.5 mm), FMNH 1402.
French Polynesia. Point Faaupo, Moorea, Society Islands, 0–2 m, under rocks, 21 October 2001, coll. G. Paulay, 1 male (sl 2.0 mm), 3 females (sl 1.4–2.0 mm), FMNH 1756.
Distribution. Widely distributed in the tropical Indo-West Pacific; intertidal to subtidal. Newly recorded from Taiwan and Marianas.
description: Published as part of Komai, Tomoyuki, 2013, Additional records of the pagurid hermit crab genus Trichopagurus de Saint Laurent, 1968 (Crustacea: Decapoda: Anomura), with description of a new species from the Philippines, pp. 274-282 in Zootaxa 3670 (2) on page 280, DOI: 10.11646/zootaxa.3670.2.10, http://zenodo.org/record/217940
Additional file 3: Figure S3. of DNA microarray revealed and RNAi plants confirmed key genes conferring low Cd accumulation in barley grains
Creators: name: Hongyan Sun
name: Chen, Zhong-Hua
name: Chen, Fei
name: Lupeng Xie
name: Guoping Zhang
name: Vincze, Eva
name: Feibo Wu
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Chlorophyll content in leaves of two barley genotypes. (DOC 150 kb)
Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review
Creators: name: Huber, D.
name: Seitz, S.
name: Kast, K.
name: Emons, G.
name: Ortmann, Olaf
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Hormone replacement therapy; Breast cancer; Ovarian cancer; BRCA1; BRCA2
subject: 610 Medizin

description: Purpose BRCA mutation carriers have an increased risk of developing breast or ovarian cancer. Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is associated with a decrease in risk for tubal and ovarian cancer. Hormone replacement therapy (HRT) may increase breast, ovarian, and endometrial cancer risk in the general population. This review analyses the published data on HRT and risk of cancer in BRCA mutation carriers with and without RRBSO. Methods We included all relevant articles published in English from 1995 to October 2020. Sources were identified through a search on PubMed and Cochrane Library. Results We included one case-control and one retrospective cohort study on ovarian and one case-control study on endometrial cancer risk and HRT in BRCA mutation carriers. Regarding breast cancer risk, one case-control study on BRCA mutation carriers with and without RRBSO and one case-control study, one Markov chain decision model, two prospective cohort studies, and one metaanalysis on carriers after RRBSO were included. For ovarian cancer, results were ambiguous. For breast cancer, most studies did not find an adverse effect associated with HRT. However, some of the studies found a risk modification associated with different formulations and duration of use. Conclusion Although data are limited, HRT does not seem to have a relevant effect on cancer risk in BRCA mutation carriers. RRBSO should not be postponed to avoid subsequent HRT in this population. Adequate HRT after RRBSO should be offered to avoid chronic diseases resulting from low estrogen levels. However, further data on the safety of different formulations are needed.
Recull de recursos sobre ciència ciutadana
Creators: name: Bellmunt, Fidel
Publisher: name: Item: revista de biblioteconomia i documentació
Year: 2024

description: Aquest recull vol complementar la informació oferida pels articles d’aquest número, aportant de manera sintètica les referències bàsiques per valorar l’interès o potencial de cadascun. El criteri de selecció seguit és el de rellevància global combinat amb la proximitat a la realitat catalana.
description: Item: revista de biblioteconomia i documentació, 2024: Núm.:76
Additional file 3: Figure S3. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: BDNF can stimulate TeA maturation and somato-dendritic coupling. A: DIV20 cultures immunocytochemically labelled with the dendritic-associated marker MAP2 under control (TeA) and BDNF treatment (TeA + BDNF) on DIV6 (50 ng/ml). Scale bar = 50 μm. B: Summary data showing the density of MAP2 positive dendrites in DIV12–20 cultures between control and BDNF treatment (t (12) = 5.28 p = 0.0002; n = 7 cultures). C: Single-cell GFP-labelled neurons under control (left) and BDNF-treated (right) conditions. TeA neurons were transfected with GFP plasmid on DIV12 and visualized on DIV13. Scale bar = 20 μm. D: Summary data of TeA neurite length between control and BDNF conditions (control n = 34 and BDNF-treated n = 29; t (61) = 7.31 p
Transient hypoglycemia as a rare cause of recurring transient loss of consciousness: a case report
Creators: name: Wester, Michael
name: Bergmann, Tanja
name: Müller-Schilling, Martina
name: Maier, Lars S.
name: Sossalla, Samuel T.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Syncope, Hypoglycemia, Transient loss of consciousness
subject: 610 Medizin

description: Background
Syncopes and transient loss of consciousness affect a large number of patients. Determining the underlying mechanism of a syncope is key to effectively treating and preventing future events. However, given the broad differential diagnosis of transient loss of consciousness, it can be challenging to determine the exact etiology.

Case presentation
This case presents a 42-year-old Caucasian female patient with recurrent transient loss of consciousness due to a hitherto undiagnosed impaired glucose tolerance and hyperinsulinism. The patient had been thoroughly tested for all typical causes of syncope without finding any causal explanation. An oral glucose tolerance test confirmed rapidly dropping blood glucose levels associated with rapidly fading consciousness as the underlying cause of transient loss of consciousness. Further diagnostic workup revealed that the patient suffered from impaired glucose tolerance and subsequent hyperinsulinism without overt diabetes mellitus. Nutritional counseling including reduction of glucose intake and frequently eating smaller meal portions led to a significant reduction in the frequency of transient loss of consciousness and overall improvement in quality of life.

Conclusions
The current European Society of Cardiology (ESC) guideline on syncope does not list hypoglycemia as a cause of transient loss of consciousness. However, this case report stresses that metabolic dysregulation can indeed lead to self-limited transient loss of consciousness. Thus, in the case of recurrent syncope with an unclear underlying mechanism, physicians should consider transient hypoglycemia and metabolic workup as a possible differential diagnosis.
绘制植物中 RNA 修饰的研究数据：从苔藓植物到开花植物的新发现和进化模式
Creators: name: Zhou, Zhongyan
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310802
subject: Plant biochemistry
classificationCode: 340101
subject: Analytical spectrometry

description: RNA 修饰对于基因表达的调节至关重要。RNA 修饰的全面分析是揭示其身份和功能的先决条件。植物激素生长素在调节植物生长、发育和环境反应中起着关键作用。与对动物的广泛研究相反，关于植物中 RNA 修饰的存在和功能的知识很少。这是由于修饰的核糖核苷丰度低且缺乏准确的分析方法。本研究采用最先进的亲水相互作用液相色谱-串联-质谱 （HILIC-MS/MS） 平台，实现了对 pM 至 nM 水平的 12 种核苷的灵敏检测。利用这个平台，我们能够在植物中鉴定出以前未表征的 RNA 修饰 N4,2'-O-二甲基胞苷 （m4Cm）。此外，还进行了全面调查，以检查从苔藓植物 （Marchantia polymorpha） 到开花植物 （拟南芥、水稻和玉米） 等一系列原型植物中的 12 种 RNA 修饰及其对生长素的反应模式。描绘了从苔藓植物到开花植物的 12 种 RNA 修饰的进化模式，并揭示了它们在植物生长、发育和生长素反应中的潜在功能。
Additional file 1: of Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia
Creators: name: Alpatov, Roman
name: Carstens, Billie
name: Harding, Kimberly
name: Jarrett, Carolyn
name: Sudabeh Balakhani
name: Lincoln, Jessica
name: Brzeskiewicz, Peter
name: Guo, Yu
name: Ohene-Mobley, Alex
name: LeRoux, Jamie
name: McDaniel, Veronica
name: Meltesen, Lynne
name: Minka, Diane
name: Patel, Mahendra
name: Manavi, Cyrus
name: Swisshelm, Karen
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Experimental procedures. (PDF 269 kb)
Additional file 4: Figure S4. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Ecology
subject: Developmental Biology
subject: Plant Biology

description: Dormant cells are neuronal in nature. A: A biocytin-filled dormant neuron (left) and NeuN co-staining of the same section (right) illustrating the nuclear region of the same cell (dotted circle). Scale bar = 25 μm. B: Summary data (t (4) = 6.83 p = 0.0024 n = 5; one-sample t test) of NeuN immunoreactivity. To make individual fluorescence measurements comparable, we normalized the ’co-labelled’ NeuN signals to the highest NeuN signals (i.e. pixel density) obtained from the same sections. Co-labelled cells generally had a less dense and more diffuse NeuN staining pattern. C: To ensure that diffuse NeuN staining was not due to recording conditions, NeuN signals were analysed for a population of TeA neurons and normalized for comparison in the same way as in panel B: a high percentage of TeA neurons have moderate to low levels of NeuN staining. **p
Trichopagurus
Creators: name: Komai, Tomoyuki
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Paguridae
Trichopagurus

description: Key to species of Trichopagurus
In the following key, non-dichotomous characters are included with brackets.
1. Chelipeds and ambulatory legs distinctly setose. Carpus of right cheliped subcylindrical, dorsomesial margin not delimited. [Carpus of left cheliped with dorsomesial spines]................................. T. trichophthalmus (Forest, 1954)
- Chelipeds and ambulatory legs only sparsely setose. Carpus of right cheliped flattened dorsoventrally.................. 2
2. Palm of right cheliped with scattered low tubercles on dorsal surface. Carpus without spines on dorsomesial margin. [Carpus of left cheliped with spines on dorsolateral and dorsomesial margins...................... T. asper Komai & Poupin, 2012
- Palm of right cheliped almost smooth on dorsal surface, carpus with spines on dorsomesial margin..................... 3
3. Carpus of left cheliped without conspicuous spines on dorsal surface. Dactylus of left third pereopod moderately slender, 10–11 times longer than broad............................................. T. macrochela Komai & Osawa, 2005
- Carpus of left cheliped armed with spines on dorsolateral and dorsomesial margins. Dactylus of left third pereopod very slen- der, about 14 times longer than broad..................................................... T. tenuidactylus n. sp.
description: Published as part of Komai, Tomoyuki, 2013, Additional records of the pagurid hermit crab genus Trichopagurus de Saint Laurent, 1968 (Crustacea: Decapoda: Anomura), with description of a new species from the Philippines, pp. 274-282 in Zootaxa 3670 (2) on page 280, DOI: 10.11646/zootaxa.3670.2.10, http://zenodo.org/record/217940
Additional file 1: of Life-table studies revealed significant effects of deforestation on the development and survivorship of Anopheles minimus larvae
Creators: name: Xiaoming Wang
name: Guofa Zhou
name: Daibin Zhong
name: Xiaoling Wang
name: Wang, Ying
name: Zhaoqing Yang
name: Liwang Cui
name: Guiyun Yan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Raw data on the survivorship of Anopheles minimus larvae in three land use and land cover conditions under natural conditions and with larval food supplemented. (DOCX 13 kb)
Additional file 6: Figure S6. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: TTX-sensitive spikes in spiking neurons from mature tissue. A: Representative current-clamp step-protocol traces from a spiking neuron under pre (Control) and post-tetrodotoxin (sodium channel blocker) application (TTX). The step protocol consisted of an initial –200 pA step followed by eight 50 pA steps (750 ms in duration) from an initial V m of –70 mV. B: Summarized data (n = 5) on the effect of TTX (1–0.1 μM) on the number of spikes per second (normalized) under control and TTX conditions in spiking neurons from tissue slices around 1 month old (t (4) = –29.7; p
Additional file 1: Table S1. of Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE
Creators: name: Yilun Wang
name: Liang, Jun
name: Haihong Qin
name: Ge, Yan
name: Du, Juan
name: Jinran Lin
name: Xiaohua Zhu
name: Wang, Jie
name: Jinhua Xu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: The top ten enriched Gene Ontology (GO) terms for target genes of all the 18 differentially expressed miRNAs. (DOCX 72Â kb)
The role of the endogenous oxytocin system under psychosocial stress conditions in adolescents suffering from anxiety disorder: study protocol for a parallel group controlled trial
Creators: name: Goetz, Leonie
name: Jarvers, Irina
name: Schleicher, Daniel
name: Mikan, Kathrin
name: Brunner, Romuald
name: Kandsperger, Stephanie
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: HPA AXIS RESPONSES; MENTAL-HEALTH; INTRANASAL OXYTOCIN; SALIVARY OXYTOCIN; PUBERTAL STATUS; SOCIAL ANXIETY; CHILD ANXIETY; CORTISOL; BRAIN; PHARMACOTHERAPY; Anxiety disorder; Case-control study; Oxytocin; Cortisol; Trier social stress test; Stress mechanisms; Children and adolescents
subject: 610 Medizin

description: Background: In social neuroscience, the linkage between the endocrinological system and the etiology and symptomatology of mental health problems has received increasing attention. A particular focus is given to the neuropeptide oxytocin with its anxiolytic and stress-buffering effect and the resulting therapeutic potential for anxiety disorders. Even though anxiety disorders are the most prevalent mental health disorders in childhood and adolescence worldwide, the reactivity of the endogenous oxytocin system to an acute stressor (Trier Social Stress Test, TSST) has so far only been investigated in healthy children. It has been shown that peripheral oxytocin levels increased under psychosocial stress conditions. In the present study, it is hypothesized that the endogenous oxytocin system in children and adolescents suffering from a clinically diagnosed anxiety disorder is dysregulated. Three primary outcome parameters will be analyzed: significant differences between participants with anxiety disorders compared to healthy controls in basal oxytocin levels, varying salivary oxytocin release after stress exposure and the correlation between the cortisol peak/-decrease and oxytocin level over time. Secondary outcome criteria are significant differences in physiological (heart rate) and psychological (perceived stress, anxiety, insecurity, tension) responses. Methods: The present study is a single-center experimental observation study to investigate the reactivity of the endocrinological system to a psychosocial stressor (TSST). 32 children and adolescents (11-18 years) suffering from anxiety disorder will be compared to a matched healthy control group. After a detailed psychological assessment, saliva samples will be taken to measure oxytocin levels before and after psychosocial stress exposure at eight different time points. Additionally, the stress hormone cortisol will be analyzed according to the same procedure. Discussion: Due to the high prevalence and comorbidity rate with numerous other psychiatric disorders and mental health problems, there is an urgent need to strengthen research in possible neurobiological underpinnings of anxiety disorders. To our knowledge, the proposed experiment is the first study to examine the endocrinological oxytocin and cortisol reaction to an acute psychosocial stressor in children and adolescents with mental health disorders.
Conventional 3D conformal radiotherapy and volumetric modulated arc therapy for cervical cancer: Comparison of clinical results with special consideration of the influence of patient- and treatment-related parameters
Creators: name: Dröge, Leif Hendrik
name: von Sivers, Franziska-Felicitas
name: Schirmer, Markus Anton
name: Wolff, Hendrik Andreas
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: PELVIC RADIOTHERAPY; ENDOMETRIAL CANCER; TARGET VOLUME; CONSENSUS GUIDELINES; FIXED FIELD; TOXICITY; CARCINOMA; OUTCOMES; IMRT; DELINEATION; Gynecologic cancer; Radiochemotherapy; Intensity-modulated radiotherapy; Urinary toxicity; Small bowel toxicity; Body mass index
subject: 610 Medizin

description: Purpose Intensity-modulated radiotherapy (IMRT) for cervical cancer yields favorable results in terms of oncological outcomes, acute toxicity, and late toxicity. Limited data are available on clinical results with volumetric modulated arc therapy (VMAT). This study's purpose is to compare outcome and toxicity with VMAT to conventional 3D conformal radiotherapy (3DCRT), giving special consideration to the influence of patient- and treatment-related parameters on side effects. Materials and methods Patients with cervical cancer stage I-IVA underwent radiotherapy alone or chemoradiotherapy using 3DCRT (n = 75) or VMAT (n = 30). Survival endpoints were overall survival, progression-free survival, and locoregional control. The National Cancer Institute Common Terminology Criteria for Adverse Events and the Late Effects of Normal Tissues criteria were used for toxicity assessment. Toxicity and patient- and treatment-related parameters were included in a multivariable model. Results There were no differences in survival rates between treatment groups. VMAT significantly reduced late small bowel toxicity (OR = 0.10, p = 0.03). Additionally, VMAT was associated with an increased risk of acute urinary toxicity (OR = 2.94, p = 0.01). A low body mass index (BMI; OR = 2.46, p = 0.03) and overall acute toxicity >= grade 2 (OR = 4.17, p < 0.01) were associated with increased overall late toxicity. Conclusion We demonstrated significant reduction of late small bowel toxicity with VMAT treatment, an improvement in long-term morbidity is conceivable. VMAT-treated patients experienced acute urinary toxicity more frequently. Further analysis of patient- and treatment-related parameters indicates that the close monitoring of patients with low BMI and of patients who experienced relevant acute toxicity during follow-up care could improve late toxicity profiles.
Apistophonte Gheerardyn and Fiers
Creators: name: Gheerardyn, Hendrik
name: Fiers, Frank
name: Vincx, Magda
name: Troch, Marleen De
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Maxillopoda
Harpacticoida
Laophontidae
Apistophonte

description: Genus Apistophonte Gheerardyn and Fiers gen. n.
Diagnosis. Laophontidae. Body fusiform prehensile. Rostrum prominent. Integument of cephalothorax and somites pitted. Posterodorsal margin of prosomites, urosomites and anal operculum serrate. Ventral surface of third male urosomite with several short rows of long spinules. Caudal rami cylindrical without dorsal processes. Female antennule 6­ segmented; first segment short, nearly quadrate; bearing small, blunt process along the outer margin. Second segment with distinct, posteriorly directed hook along the outer margin. Syncoxa of maxilla with 3 endites. P1 with 2­segmented exopod and endopod. Swimming legs P2–P4 with 3­segmented exopods and 2­segmented endopods; without sexual dimorphism except for a curved, stronger outer spine on exp­2 of the male P3. Chaetotaxy of the ultimate exopodal segments of P2–P4: 122, 222 and 222. Endopodal lobe of female P5 reaching to middle of exopod, bearing 4 setae. Exopod of female P5 ovate, bearing 5 setae. Male P5 baseoendopod obsolete, without endopodal seta; exopod small, bearing 3 setae.
Type species. Apistophonte wasiniensis gen. n. sp. n., monotypy.
Etymology. The generic name is a conjunction of apistos (Greek meaning treacherous, perfidious) and the suffix – phonte, and refers to the superficial and misleading resemblance of the genus to Propephonte gen. n. (gender feminine).
The above diagnosis coincides with that of its only known and type species, and must, therefore, be considered tentative. A differential diagnosis is presented in the discussion.
description: Published as part of Gheerardyn, Hendrik, Fiers, Frank, Vincx, Magda & Troch, Marleen De, 2006, Two new genera of Laophontidae (Copepoda: Harpacticoida) without sexual dimorphism in the endopods of the swimming legs, pp. 41-62 in Zootaxa 1327 on page 43, DOI: 10.5281/zenodo.174137
Additional file 2: Figure S2. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology

description: Recordable currents from TeA dendrites. A: Differential interference contrast (DIC) microscopy images of the same pyramidal neuron illustrating recordings targeted to a dendrite (left) and to that of the soma (right). Scale bar = 20 μm. B: Corresponding current traces from somatic (red) and dendritic (black) recordings in response to a voltage ramp from –120 to +50 mV. The corresponding traces from panel A are shown in purple and blue for the dendrite and soma respectively for the same cell example. Note that a total of four traces have been shown for each group (i.e. soma and dendrite). C–D: Summary data demonstrating significantly lower membrane conductance (G) at both hyperpolarized (–100 mV; t (5) = 3.18 Welch-corrected p = 0.024) and depolarized (+50 mV; t (5) = 3.29 Welch-corrected p = 0.022) potentials from somatic (n = 11) compared to dendritic (n = 6) recordings. *p
Additional file 2: Table S2. of Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE
Creators: name: Yilun Wang
name: Liang, Jun
name: Haihong Qin
name: Ge, Yan
name: Du, Juan
name: Jinran Lin
name: Xiaohua Zhu
name: Wang, Jie
name: Jinhua Xu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: The top ten enriched pathways for target genes of all the 18 differentially expressed miRNAs. (DOCX 68Â kb)
АНАЛИЗ ВЛИЯНИЯ ПРОЦЕССОВ ПРИВАТИЗАЦИИ НА ЗАНЯТОСТЬ В РЕСПУБЛИКЕ УЗБЕКИСТАН
Creators: name: Кадыров, Тохиржан
Publisher: name: Zenodo
Year: 2024

description: В данной статье изучены вопросы влияния процессов приватизации на занятость в Республике Узбекистан. Проведен анализ развития доли приватизированных предприятий и вновь созданных предприятий, количества занятых, уровня занятости, количества безработных в период 2021-2023гг. Проведен корреляционный анализ взаимосвязи между показателями приватизации и показателями занятости. На основе проведенного анализа получены результаты исследования, показывающие взаимосвязь между данными показателями, позволяющими определить дальнейшие направления и темпы проведения приватизации.
Additional file 7: Figure S7. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Hematology

description: Presence of anionic but not cationic membrane current. A: Representative current traces (left) for both low free bicarbonate (red; n = 15; pH 3.5–4; 50 mM NaHCO3) and high free bicarbonate ion (black; n = 14; pH 8–8.5; 50 mM NaHCO3) internal pipette recording conditions are shown in A. Cells were held at –60 mV and a voltage command ramp from –120 to +50 mV was applied. (Right) Group data illustrating a significant larger slope conductance (G) under alkaline conditions (t (13) = 3.80 Welch-correction p = 0.0022 on square rooted-transformed data to minimize distribution skew). Importantly, under these conditions, cells still failed to demonstrate action potential and rectifying currents under both ramp or step protocols. B: Given the lack of any observable current under acidic recording conditions, the membrane impermeable amphipathic dye FM1-43 (≈40 μM) was included in the pipette (n = 10). Scale bar = 20 μm. C: Current traces (left) from the same cell under high free bicarbonate internal recording conditions before (black) and after (orange) bath application of the anionic (chloride and electrogenic NBC co-transporter) channel blockers SITS and DIDS (≈1 mM). Cells were held at a holding potential of –60 mV and a voltage command ramp from –160 to +80 mV was applied. (Right) Summary data showing that the high free bicarbonate internal recording condition membrane current is sensitive to both SITS and/or DIDS. Bath application of SITS and/or DIDS led to a significant decrease in recordable current (Wilcoxon signed-rank test W = –36.0, p = 0.0039 n = 8). When stratified into individual or combined drug application, similar findings were observed (t (3) = 5.60 p = 0.011 one-sample t test and t (3) = 33.38 p
Breastfeeding behavior is not associated with health literacy: evidence from the German KUNO-Kids birth cohort study
Creators: name: Graus, Teresa M.
name: Brandstetter, Susanne
name: Seelbach-Göbel, Birgit
name: Melter, Michael
name: Kabesch, Michael
name: Apfelbacher, Christian J.
name: Fill Malfertheiner, Sara
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: PUBLIC-HEALTH; DURATION; VERSION; TREND; Health literacy; Health care; Breastfeeding; Breastfeeding promotion
subject: 610 Medizin

description: Purpose Despite the health benefits of full breastfeeding for both infants and mothers, less than 50% of mothers in Germany practice this method for at least 4 months after childbirth. Because of the growing importance of health literacy to improve public health, we investigated the role of maternal health literacy in breastfeeding behavior. Methods We analyzed the data of 1172 mother-child dyads of the KUNO-Kids health study of the University Children's and Maternity Hospital Regensburg. Maternal health literacy was assessed with the HLS-EU-Q47 questionnaire (sub-index health care) up to 48 h after childbirth. Outcome was analyzed 6 months after childbirth and categorized into full breastfeeding for less than 4 months or for at least 4 months. The association between breastfeeding and maternal health literacy was calculated with univariable and multivariable logistic regression analyses. Results 38.8% of mothers showed inadequate or limited health literacy. 75.9% of mothers had fully breastfed their child for at least 4 months. Univariable logistic regression analysis showed that health literacy and full breastfeeding for at least 4 months were not associated (OR = 0.995 [CI 0.977-1.015], p = 0.60). After adjusting for all potentially confounding variables with a significant association (p <= 0.05) on both health literacy and breastfeeding, the multivariable model showed no association between health literacy and breastfeeding (OR = 0.984 [CI 0.963-1.007], p = 0.170). Conclusion Surprisingly, we found no association between health literacy and breastfeeding behavior in our study. Therefore, future research with comparable measurements of health literacy and breastfeeding is required to validate this result and to identify reasons for early breastfeeding cessation.
The epidemiology of fracture-related infections in Germany
Creators: name: Rupp, Markus
name: Walter, Nike
name: Lang, Siegmund
name: Alt, Volker
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: INTERNAL-FIXATION; RISK-FACTORS; COMPLICATIONS; PREVALENCE; TRAUMA; TRENDS
subject: 610 Medizin

description: The epidemiology of fracture-related infection (FRI) is unknown, which makes it difficult to estimate future demands and evaluate progress in infection prevention. Therefore, we aimed to determine the nationwide burden's development over the last decade as a function of age group and gender. FRI prevalence as a function of age group and gender was quantified based on annual ICD-10 diagnosis codes from German medical institutions between 2008 through 2018, provided by the Federal Statistical Office of Germany (Destatis). The prevalence of FRI increased by 0.28 from 8.4 cases per 100,000 inhabitants to 10.7 cases per 100,000 inhabitants between 2008 and 2018. The proportion of fractures resulting in FRI increased from 1.05 to 1.23%. Gender distribution was equal. Patients aged 60-69 years and 70-79 years comprised the largest internal proportion with 20.2% and 20.7%, respectively, whereby prevalence increased with age group. A trend towards more diagnoses in older patients was observed with a growth rate of 0.63 for patients older than 90 years. Increasing rates of fracture-related infection especially in older patients indicate an upcoming challenge for stakeholders in health care systems. Newly emerging treatment strategies, prevention methods and interdisciplinary approaches are strongly required.
Additional file 8: Figure S8. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: Hematology

description: Optical changes driven by the imposed pipette tonicity. A–B: A schematic illustration of the experiments to confirm a whole-cell configuration based on the characteristic feature that, under whole-cell conditions, the properties of the pipette solution are imposed to the cytosol through dialysis. Here a hypotonic pipette solution was used to provide a driving force for the movement of ions from the cell interior to the pipette during dialysis (red arrow; panel A). Following dialysis (e.g. >3 min) the interior of the cell becomes like the pipette solution (i.e. hypotonic), thus leading to a crenation-like effect in cell shape as water moves out of the cell (panel A). Conversely, using a hypertonic pipette solution will result in the opposite effect; ions move into the cell and ultimately lead to cell swelling membrane dimpling (panel B). C: Representative examples of these types of responses, which were quite robust occurring in 100 % of cells tested. Under these conditions cells still failed to demonstrate action potential and rectifying currents. D: This response can be partially quantified using an ImageJ profile analysis where the grey value represents regions of high contrast (e.g. edges) from the DIC image region of interest (orange line; the coloured arrows correspond to the same spatial locations as in panel C). It should be mentioned that unlike the XY planes of the cell which are associated with the coverslip, changes could also be observed in the Z plane but were difficult to quantify. The colors correspond to the initial condition (green) and the dialyzed condition (orange) for both panels C and D. E: The summarized data represent the proportional change in cross-sectional distance of dormant cells for both the hypertonic (light grey; n = 6; t (5) = 4.28, one-sampled t test p = 0.0079) and hypotonic (dark grey; n = 5; t (4) = 10.51, one-sampled t test p = 0.0005) conditions. Note that volume increases non-linearly with distance. * denotes p
Additional file 5: Figure S5. of Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation
Creators: name: Chomiak, Taylor
name: Hung, Johanna
name: Nguyen, Minh
name: Hu, Bin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Lack of age-dependent increase in cell number in TeA. A: Representative images of juvenile and mature tissue sections illustrating a comparable pattern of DAPI (blue) and NeuN (green) staining. Neurofilament-200 (red) was also included here to illustrate the surrounding neuropil. Note that the intensity of DAPI staining appears, in general, weaker and more dispersed in older animals. Scale bar = 50 μm. B–C: Summarized cell count data based on DAPI (B) and NeuN (C) staining normalized for comparison. Note that there does not appear to be an increase in cell number for both the total number of cells and NeuN positive cells between juvenile (P19; n = 3 animals) and mature (P57; n = 3 animals) animals using both counting methods (t (4) = 1.45 p = 0.22 for DAPI and t (4) = 1.69 p = 0.17 for NeuN). These results are consistent with the general notion that the postnatal neocortex does not appear to produce more neurons [51]. (PDF 695 kb)
Additional file 1: of The gut microbiota in young and middle-aged rats showed different responses to chicken protein in their diet
Creators: name: Yingying Zhu
name: Li, He
name: Xinglian Xu
name: Chunbao Li
name: Guanghong Zhou
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Table S1. Richness and diversity indexes relative to each sample. Table S2. The differentially fecal bacterial communities between Young-0d and Middle aged-0d using LEfSe at the OTU level. Table S3. The differentially fecal bacterial communities between Young-14d and Middle aged-14d using LEfSe at the OTU level. Table S4. The differentially fecal bacterial communities between Young-0d and Young-14d using LEfSe at the OTU level. Table S5. The differentially fecal bacterial communities between Middle aged-0d and Middle aged-14d using LEfSe at the OTU level. (DOC 254 kb)
Chlaenius (Agostenus) Fischer von Waldheim 1829
Creators: name: Sundukov, Yurii N.
name: Makarov, Kirill V.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Chlaenius

description: Key to the Far Eastern species of the subgenus Agostenus Fischer von Waldheim, 1829, genus Chlaenius Bonelli, 1810
1. Even intervals of elytra more densely punctured, with denser yellow pubescence; odd intervals with less dense black hairs; suture elevated and shining (Figs 16–18). Unicolour black with slight bronze tint. Length 14–18 mm ................... …............................................................................. Chlaenius quadrisulcatus
- All intervals of elytra with dense wrinkled punctures and uniform yellow or grey pubescence; elytral suture neither elevated nor shining (Figs 13–15).................................................................................. 2
2. Prosternal process not bordered and punctured. Larger (length 13–15 mm) and wider. Head without green sheen (Figs 14–15) Chlaenius sulcicollis
- Prosternal process distinctly bordered and smooth. Smaller (length 12–13 mm) and narrower. Head often with green or copper sheen (Figs 13)...................................................................... Chlaenius alutaceus
description: Published as part of Sundukov, Yurii N. & Makarov, Kirill V., 2022, Notes on the systematics and nomenclature of some taxa of the genus Chlaenius Bonelli, 1810 (Coleoptera, Carabidae) from the Far East, pp. 190-200 in Zootaxa 5222 (2) on page 198, DOI: 10.11646/zootaxa.5222.2.7, http://zenodo.org/record/7456761
Additional file 1: Figure S1. of Knockdown of five trehalase genes using RNA interference regulates the gene expression of the chitin biosynthesis pathway in Tribolium castaneum
Creators: name: Tang, Bin
name: Wei, Ping
name: Zhao, Lina
name: Zuokun Shi
name: Qida Shen
name: Mengmeng Yang
name: Guoqiang Xie
name: Shigui Wang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Synthesis and degradation of trehalose and glycogen in insects. Adapted from Rockstein [16], Elbein et al. [17], Montooth et al. [18], Kunieda et al. [19], and Tang et al. [20]. The red arrow and dotted arrow indicate that the enzyme in this pathway was analysed and that this pathway is unknown, respectively. Figure S2: Alignment of the nucleotide sequences of five TcTre genes in the region of the dsRNAs. (DOCX 21Â kb)