cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Radial Covariance Functions Motivated by Spatial Random Field Models with Local Interactions
Creators: name: Hristopulos, Dionissios T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62M30, 62H11, 62-07, 62H10, 62H12, 62-07

description: We derive explicit expressions for a family of radially symmetric, non-differentiable, Spartan covariance functions in $\mathbb{R}^2$ that involve the modified Bessel function of the second kind. In addition to the characteristic length and the amplitude coefficient, the Spartan covariance parameters include the rigidity coefficient $η_{1}$ which determines the shape of the covariance function. If $ η_{1} >> 1$ Spartan covariance functions exhibit multiscaling. We also derive a family of radially symmetric, infinitely differentiable Bessel-Lommel covariance functions valid in $\mathbb{R}^{d}, d\ge 2$. We investigate the parametric dependence of the integral range for Spartan and Bessel-Lommel covariance functions using explicit relations and numerical simulations. Finally, we define a generalized spectrum of correlation scales $λ^{(α)}_{c}$ in terms of the fractional Laplacian of the covariance function; for $0 \le α\le1$ the $λ^{(α)}_{c}$ extend from the smoothness microscale $(α=1)$ to the integral range $(α=0)$. The smoothness scale of mean-square continuous but non-differentiable random fields vanishes; such fields, however, can be discriminated by means of $λ^{(α)}_{c}$ scales obtained for $α<1$.
description: 14 pages, 10 figures, 5 Appendices; Version 2: minor typos corrected
A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki
Creators: name: Negulescu, Horia
name: Guo, Youzhong
name: Garner, Thomas P.
name: Goodwin, Octavia Y.
name: Henderson, Gregg
name: Laine, Roger A.
name: Macnaughtan, Megan A.
Publisher: name: Columbia University
Year: 2015
Subjects: Proteins--Structure
Proteins--Secretion
Rhinotermitidae
Amino acid sequence
Protease inhibitors
Formosan subterranean termite
Biochemistry
Entomology

description: Coptotermes formosanus is an imported, subterranean termite species with the largest economic impact in the United States. The frontal glands of the soldier caste termites comprising one third of the body mass, contain a secretion expelled through a foramen in defense. The small molecule composition of the frontal gland secretion is well-characterized, but the proteins remain to be identified. Herein is reported the structure and function of one of several proteins found in the termite defense gland secretion. TFP4 is a 6.9 kDa, non-classical group 1 Kazal-type serine protease inhibitor with activity towards chymotrypsin and elastase, but not trypsin. The 3-dimensional solution structure of TFP4 was solved with nuclear magnetic resonance spectroscopy, and represents the first structure from the taxonomic family, Rhinotermitidae. Based on the structure of TFP4, the protease inhibitor active loop (Cys8 to Cys16) was identified.
Bias Characterization in Probabilistic Genotype Data and Improved Signal Detection with Multiple Imputation
Creators: name: Palmer, Cameron Douglas
name: Pe’er, Itsik
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Multiple imputation (Statistics)
subject: Missing observations (Statistics)
subject: Genetics--Statistical methods
subject: Genetics
subject: FOS: Biological sciences
subject: Statistics
subject: FOS: Mathematics

description: Missing data are an unavoidable component of modern statistical genetics. Different array or sequencing technologies cover different single nucleotide polymorphisms (SNPs), leading to a complicated mosaic pattern of missingness where both individual genotypes and entire SNPs are sporadically absent. Such missing data patterns cannot be ignored without introducing bias, yet cannot be inferred exclusively from nonmissing data. In genome-wide association studies, the accepted solution to missingness is to impute missing data using external reference haplotypes. The resulting probabilistic genotypes may be analyzed in the place of genotype calls. A general-purpose paradigm, called Multiple Imputation (MI), is known to model uncertainty in many contexts, yet it is not widely used in association studies. Here, we undertake a systematic evaluation of existing imputed data analysis methods and MI. We characterize biases related to uncertainty in association studies, and find that bias is introduced both at the imputation level, when imputation algorithms generate inconsistent genotype probabilities, and at the association level, when analysis methods inadequately model genotype uncertainty. We find that MI performs at least as well as existing methods or in some cases much better, and provides a straightforward paradigm for adapting existing genotype association methods to uncertain data.
Dactylomys I. Geoffrey 1838
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Echimyidae
Dactylomys

description: Dactylomys I. Geoffrey, 1838. Ann. Sci. Nat. Paris Zool., ser. 2, 10: 126. COMMENT: Includes Lachnomys; see Cabrera, 1961:543. ISIS NUMBER: 5301410029012000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 586, DOI: 10.5281/zenodo.7353039
Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation
Creators: name: Zhu, Jun
name: Hou, Qiang
name: Da Dong, Xiang
name: Wang, Zhenlian
name: Chen, Xiaoyan
name: Zheng, Dandan
name: Zhou, Linglin
name: He, Chao
name: Liu, Mingyao
name: Tu, LiLi
name: Qu, Jia
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Cataract--Etiology
subject: G proteins--Receptors
subject: Antioxidants--Physiological effect
subject: Cataract in old age
subject: Medical genetics--Research
subject: Oxidative stress--Pathophysiology
subject: Genetics
subject: FOS: Biological sciences
subject: Biomedical engineering
subject: Ophthalmology
subject: Pathology

description: Oxidative stress contributes to the formation of cataracts. The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes. Since deletion of Lgr4 has previously been shown to lead to cataract formation in mice, we sought to determine the specific role that Lgr4 plays in the formation of cataracts. Initially, the lens opacities of Lgr4−/− mice at different ages without ocular anterior segment dysgenesis (ASD) were evaluated with slit-lamp biomicroscopy. Lenses from both Lgr4−/− and wild-type mice were subjected to oxidation induced protein denaturation to assess the ability of the lens to withstand oxidation. The expression of antioxidant enzymes was evaluated with real-time quantitative PCR. Phenotypically, Lgr4−/− mice showed earlier onset of lens opacification and higher incidence of cataract formation compared with wild-type mice of similar age. In addition, Lgr4−/− mice demonstrated increased sensitivity to environmental oxidative damage, as evidenced by altered protein expression. Real-time quantitative PCR showed that two prominent antioxidant defense enzymes, catalase (CAT) and superoxidase dismutase-1 (SOD1), were significantly decreased in the lens epithelial cells of Lgr4−/− mice. Our results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging. Oxidative stress and altered expression of several antioxidant defense enzymes contribute to the formation of cataracts.
Practical Black-Box Analysis for Network Functions and Services
Creators: name: Moon, Soo-Jin
Publisher: name: Carnegie Mellon University
Year: 2020
Subjects: Computer Engineering

description: Modern networks are exploding with an increasing array of diverse network functions (e.g., network firewalls) and services (e.g., public servers). Despite their critical role in our modern infrastructure, they remain largely black-box in nature, given that they are proprietary or configured and deployed by third parties. This black-box nature makes it fundamentally difficult for operators and Internet securityexperts to reason about security implications and correctness of these functions and services. Unfortunately, this lack of understanding and analysis leaves gaps forhigh-impact network attacks exploiting their insecurities and network outages. This dissertation aims to bridge this operational gap by building techniques to automatically analyze the behavior and vulnerabilities of these network devices and services. Specifically, we design techniques to (1) automatically infer high-fidelity models to enable accurate testing and verification, and (2) identify new avenues for potential abuse against network functions and services. Given that we only have black-box access, our techniques do not require access to the code or binary forinstrumentation. However, designing these techniques is challenging. First, we need to reason about their behavior under a large traffic space and possible configurations.Second, they may exhibit complicated (hidden) behaviors. Our high-level approach in building these tools is to leverage structural properties inherent to black-boxes and their input and configuration space. This insight allows us to reduce the relevant search space and efficiently search over the relevant part of the search space. The key contributions of this thesis are three concrete tools. First, is Alembic, atool that can automatically synthesize high-fidelity models of stateful network functions, for accurate testing and verification workflow. Second, is Pryde, a tool whichprovides operators with capabilities for identifying subtle evasion vulnerabilities in stateful firewalls. Lastly, is AmpMap, a low-footprint measurement framework thatcan systematically quantify the amplification risk against black-box protocol servers at scale. In presenting each of these tools, we highlight how each tool (1) uncoveredunexpected behavior and new security vulnerabilities, and (2) highlighted significant variability in the behavior and security implications of these black-boxes acrossvendors and implementations. Our findings and results affirm the need for automatic tools to analyze the behaviors for black-box functions and services to properly understand their security implications.
British Columbia Legislative Assembly sessional clipping book (1915-01)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Performing well in financial management and quality of care: evidence from hospital process measures for treatment of cardiovascular disease
Creators: name: Dong, Gang Nathan
Publisher: name: Columbia University
Year: 2015
Subjects: Hospitals--Finance
Cardiovascular system--Diseases--Treatment
Health services administration
Medical care

description: Background: Fiscal constraints faced by U.S. hospitals as a result of the recent economic downturn are leading to business practices that reduce costs and improve financial and operational efficiency in hospitals. There naturally arises the question of how this finance-driven management culture could affect the quality of care. This paper attempts to
determine whether the process measures of treatment quality are correlated with hospital financial performance. Methods: Panel study of hospital care quality and financial condition between 2005 and 2010 for cardiovascular disease treatment at acute care hospitals in the United States. Process measures for condition-specific treatment of heart attack and heart failure and hospital-level financial condition ratios were collected from the CMS databases of Hospital Compare and Cost Reports.
Results: There is a statistically significant relationship between hospital financial performance and quality of care. Hospital profitability, financial leverage, asset liquidity, operating efficiency, and costs appear to be important factors of health care quality. In general, public hospitals provide lower quality care than their nonprofit counterparts, and urban
hospitals report better quality score than those located in rural areas. Specifically, the first-difference regression results indicate that the quality of treatment for cardiovascular patients rises in the year following an increase in hospital profitability, financial leverage, and labor costs.
Conclusions: The results suggest that, when a hospital made more profit, had the capacity to finance investment using debt, paid higher wages presumably to attract more skilled nurses, its quality of care would generally improve. While the pursuit of profit induces hospitals to enhance both quantity and quality of services they offer, the lack of financial strength may result in a lower standard of health care services, implying the importance of monitoring the quality of care among those hospitals with poor financial health.
title: DIe zVVeIJte Messe eInes PrIesters Vnserer GeseLLsChafft JesV; [1726]
title: Die Kirch des heiligen Ertz-Engels Michaël der Gesellschafft Jesu in der Stadt Steyr Wünschet Glück Dem Ehrwürdigen P. Jacobo Marell Aus gemeldter Gesellschaft Jesu, Durch heilige Weyhen und Biblische Gastmahl, so von der Dicht-Kunst in Vers gebunden, da selber nach zuruckgelegten fünffzig Jahren seines Priesterthums Gott zum zweytenmahl das unblutige Opffer dargeboten. Jn dem Jubel-Jahr M.DCC.XXVI. den neunten Junij
titleType: Subtitle
Creators: name: Marell, Jakob
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Vorlageform des Erscheinungsvermerks: Gedruckt zu Steyr bey Joseph Grünenwald.
Randomly Fluctuating Potential Controlled Multistable Resonant Tunneling Current through a Quantum Dot
Creators: name: Wang, Pei
name: Xianlong, Gao
name: Xu, Shaojun
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the transport through a quantum dot subject to a randomly fluctuating potential, generated by a sequence of pulses in the gate voltage with the help of the autoregressive model. We find that the tunneling current is multistable when the fluctuating potential with a finite correlation time is applied before the non-equilibrium steady state is built up. The non-equilibrium stationary current is heavily dependent on the history of the fluctuating potential during the transient period if the potential has a finite correlation time. Furthermore, the averaged current over the path of the fluctuating potential is a function of its strength and correlation time. Our work therefore provides a robust theoretical proposal for the controlling of the non-equilibrium stationary current through a quantum dot in a randomly fluctuating potential.
description: 6 pages, 5 figures
AIXtal – AI aided Web Refinement Platform for First-Time Users
Creators: name: Houben, Andreas
name: Hartwig, Jannes
name: Nachtigall, Noah
name: Dronskowski, Richard
Publisher: name: Zenodo
Year: 2024

description: AIXtal is a web-based easy-access refinement platform to cater specifically first-time users. AIXtal offers a simplified user interface with reduced complexity, including tutorials, tooltips, and AI helpers for assistance. Currently, AIXtal supports GSAS-II and Fullprof refinements on X-ray powder diffraction data.

 The platform provides the visualization of structural, experimental and refinement data, including a simplified, graphical background selection. The user is assisted by on-demand assistance on refinement parameters, either by short tooltips or by an AI-guide semi-quantitatively judging the last refinement result/parameters and thereby recommending next refinement steps. For more in-depth investigation, the user may also access a compact view (web or PDF) of refinement parameters, including esd’s. If unfavorable refinement steps are indicated, the user can trust on the history function to jump back to any time wanted. Additionally, AIXtal allows users to export the refinement results in GPX format, allowing for further analysis with GSAS-II, if needed at all.

 Current status, AI-helpers and features of AIXtal as well as its technical design principles are shown.
Connectivity and circuitry in a dish versus in a brain
Creators: name: Chinchalongpom, Vorapin
name: Koppensteiner, Peter
name: Prè, Deborah
name: Thangnipon, Wipawan
name: Bilo, Leonilda
name: Arancio, Ottavio
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Neural circuitry
subject: Neurosciences
subject: FOS: Clinical medicine

description: In order to understand and find therapeutic strategies for neurological disorders, disease models that recapitulate the connectivity and circuitry of patients’ brain are needed. Owing to many limitations of animal disease models, in vitro neuronal models using patient-derived stem cells are currently being developed. However, prior to employing neurons as a model in a dish, they need to be evaluated for their electrophysiological properties, including both passive and active membrane properties, dynamics of neurotransmitter release, and capacity to undergo synaptic plasticity. In this
review, we survey recent attempts to study these issues in human induced pluripotent stem cell-derived neurons. Although progress has been made, there are still many hurdles to overcome before human induced pluripotent stem cell-derived neurons can fully recapitulate all of the above physiological properties of adult mature neurons. Moreover, proper integration of neurons into pre-existing circuitry still needs to be achieved. Nevertheless, in vitro neuronal stem cell-derived models hold great promise for clinical application in neurological diseases in the future.
The HIV epidemic and sexual and reproductive health policy integration: views of South African policymakers
Creators: name: Cooper, Diane
name: Mantell, Joanne E.
name: Moodley, Jennifer
name: Mall, Sumaya
Publisher: name: Columbia University
Year: 2015
Subjects: HIV (Viruses)--Government policy
Public health

description: Background: Integration of sexual and reproductive health (SRH) and HIV policies and services delivered by the same provider is prioritised worldwide, especially in sub-Saharan Africa where HIV prevalence is highest. South Africa has the largest antiretroviral treatment (ART) programme in the world, with an estimated 2.7 million people on ART,
elevating South Africa’s prominence as a global leader in HIV treatment. In 2011, the Southern African HIV Clinicians Society published safer conception guidelines for people living with HIV (PLWH) and in 2013, the South African government published contraceptive guidelines highlighting the importance of SRH and fertility planning services for people living with HIV. Addressing unintended pregnancies, safer conception and maternal health issues is crucial for improving PLWH’s SRH and combatting the global HIV epidemic. This paper explores South African policymakers’ perspectives on public sector SRH-HIV policy integration, with a special focus on the need for national and regional policies on safer conception for PLWH and contraceptive guidelines implementation. Methods: It draws on 42 in-depth interviews with national, provincial and civil society policymakers conducted between 2008–2009 and 2011–2012, as the number of people on ART escalated. Interviews focused on three key
domains: opinions on PLWH’s childbearing; the status of SRH-HIV integration policies and services; and thoughts and suggestions on SRH-HIV integration within the restructuring of South African primary care services. Data were coded and analysed according to themes. Results: Participants supported SRH-HIV integrated policy and services. However, integration challenges identified included a lack of policy and guidelines, inadequately trained providers, vertical programming, provider work
overload, and a weak health system. Participants acknowledged that SRH-HIV integration policies, particularly for safer conception, contraception and cervical cancer, had been neglected. Policymakers supported public sector adoption of safer conception policy and services. Participants interviewed after expanded ART were more positive about safer conception policies for PLWH than participants interviewed earlier.
Conclusion: The past decade’s HIV policy changes have increased opportunities for SRH–HIV integration. The findings provide important insights for international, regional and national SRH-HIV policy and service integration initiatives.
Resurgence theory, ghost-instantons, and analytic continuation of path integrals
Creators: name: Basar, Gokce
name: Dunne, Gerald V.
name: Unsal, Mithat
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A general quantum mechanical or quantum field theoretical system in the path integral formulation has both real and complex saddles (instantons and ghost-instantons). Resurgent asymptotic analysis implies that both types of saddles contribute to physical observables, even if the complex saddles are not on the integration path i.e., the associated Stokes multipliers are zero. We show explicitly that instanton-anti-instanton and ghost--anti-ghost saddles both affect the expansion around the perturbative vacuum. We study a self-dual model in which the analytic continuation of the partition function to negative values of coupling constant gives a pathological exponential growth, but a homotopically independent combination of integration cycles (Lefschetz thimbles) results in a sensible theory. These two choices of the integration cycles are tied with a quantum phase transition. The general set of ideas in our construction may provide new insights into non-perturbative QFT, string theory, quantum gravity, and the theory of quantum phase transitions.
description: 35 pages, 10 figures, v2: references added
Molecular differences between stromal cell populations from deciduous and permanent human teeth
Creators: name: Kaukua, Nina
name: Chen, Mo
name: Guarnieri, Paolo
name: Dahl, Markus
name: Lim, Mei Ling
name: Yucel-Lindberg, Tülay
name: Sundström, Erik
name: Adameyko, Igor
name: Mao, Jeremy J.
name: Fried, Kaj
Publisher: name: Columbia University
Year: 2015
Subjects: Mesenchymal stem cells
Teeth
Medicine

description: Introduction: Deciduous and permanent human teeth represent an excellent model system to study aging of stromal populations. Aging is tightly connected to self-renewal and proliferation and thus, mapping potential molecular differences in these characteristics between populations constitutes an important task. Methods: Using specifically designed microarray panels, Real-Time Quantitative Polymerase Chain Reaction (RT q-PCR), Western blot, immunohistochemistry and siRNA-mediated knock down experiments, we have detected a number of molecules that were differentially expressed in dental pulp from deciduous and permanent teeth extracted from young children and adults, respectively. Results: Among the differentially regulated genes, high-mobility group AT-hook 2 (HMGA2), a stem cell-associated marker, stood out as a remarkable example with a robust expression in deciduous pulp cells. siRNA-mediated knock down of HMGA2 expression in cultured deciduous pulp cells caused a down-regulated expression of the pluripotency marker NANOG. This finding indicates that HMGA2 is a pulpal stem cell regulatory factor. In addition to this, we discovered that several proliferation-related genes, including CDC2A and CDK4, were up-regulated in deciduous pulp cells, while matrix
genes COL1A1, fibronectin and several signaling molecules, such as VEGF, FGFr-1 and IGFr-1 were up-regulated in the pulp cells from permanent teeth.
Conclusions: Taken together, our data suggest that deciduous pulp cells are more robust in self- renewal and proliferation, whereas adult dental pulp cells are more capable of signaling and matrix synthesis.
Observations of low- and intermediate-frequency-peaked BL Lacs above 100 GeV with VERITAS
Creators: name: Errando, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Most of the ~50 blazars detected to date at TeV energies (E>0.1 TeV) are high-frequency-peaked BL Lacs (HBLs). Only a handful episodic TeV detections of low- and intermediate-frequency-peaked BL Lacs (LBL/IBLs, with synchrotron peak frequencies in the infrared and optical regime) have been reported, typically during high-flux states. The VERITAS array, a ground-based TeV observatory located in southern Arizona has observed five known TeV LBL/IBLs since 2009: 3C 66A, W Comae, PKS 1424+240, S5 0716+714 and BL Lacertae, with at least 5-10 hours/year, which so far resulted in the detection of a bright, sub-hour timescale gamma-ray flare of BL Lacertae in June 2011. We also report the detection and characterization of two new IBLs: VER J0521+211 and B2 1215+30.
description: 4 pages, 4 figures, 1 table. To appear in the proceedings of "The Innermost Regions of Relativistic Jets and Their Magnetic Fields", Granada, Spain
Tailored approaches to stroke health education (TASHE): study protocol for a randomized controlled trial
Creators: name: Ravenell, Joseph
name: Leighton-Herrmann, Ellyn
name: Abel-Bey, Amparo C.
name: DeSorbo, Alexandra
name: Teresi, Jeanne
name: Valdez, Lenfis
name: Gordillo, Madeleine C.
name: Gerin, William
name: Hecht, Michael
name: Ramirez, Mildred
name: Noble, James M.
name: Cohn, Elizabeth
name: Jean-Louis, Giardin
name: Spruill, Tanya
name: Waddy, Salina
name: Ogedegbe, Gbenga
name: Williams, Olajide A.
Publisher: name: Columbia University
Year: 2015
Subjects: Minorities
Cerebrovascular disease
Health education

description: Background: Stroke is a leading cause of adult disability and mortality. Intravenous thrombolysis can minimize disability when patients present to the emergency department for treatment within the 3 − 4½ h of symptom onset. Blacks and Hispanics are more likely to die and suffer disability from stroke than whites, due in part to delayed hospital arrival and ineligibility for intravenous thrombolysis for acute stroke. Low stroke literacy (poor knowledge of stroke symptoms and when to call 911) among Blacks and Hispanics compared to whites may contribute to disparities in acute stroke treatment and outcomes. Improving stroke literacy may be a critical step along the pathway to reducing stroke disparities. The aim of the current study is to test a novel intervention to increase stroke literacy in minority populations in New York City. Design and Methods: In a two-arm cluster randomized trial, we will evaluate the effectiveness of two culturally
tailored stroke education films – one in English and one in Spanish – on changing behavioral intent to call 911 for suspected stroke, compared to usual care. These films will target knowledge of stroke symptoms, the range of severity of symptoms and the therapeutic benefit of calling 911, as well as address barriers to timely presentation to the hospital. Given the success of previous church-based programs targeting behavior change in minority populations, this trial will be conducted with 250 congregants across 14 churches (125 intervention; 125 control). Our proposed outcomes are (1) recognition of stroke symptoms and (2) behavioral intent to call 911 for suspected stroke, measured using the Stroke Action Test at the 6-month and 1-year follow-up. Discussion: This is the first randomized trial of a church-placed narrative intervention to improve stroke outcomes in urban Black and Hispanic populations. A film intervention has the potential to make a significant public health impact,
as film is a highly scalable and disseminable medium. Since there is at least one church in almost every neighborhood in the USA, churches have the ability and reach to play an important role in the dissemination and translation of stroke prevention programs in minority communities.
Mechanisms of chronic pain
Creators: name: Scholz, Joachim
Publisher: name: Columbia University
Year: 2014
Subjects: Nociceptive pain
Chronic pain
Medicine

description: Chronic pain is classified as nociceptive or neuropathic, depending on whether the integrity of the somatosensory nervous system is compromised by the underlying disease. Nociceptive pain results from the activation of receptors (nociceptors) sensitive to noxious stimuli. Prolonged or intense exposure to these stimuli, for example, chemical mediators released during inflammation, enhances the responsiveness of nociceptive nerve fibers. This process, termed peripheral sensitization, involves a shift in the activation threshold of nociceptors and upregulation of voltage-gated sodium channels. Peripheral sensitization leads to increased action potential firing and transmitter release in the dorsal horn of the spinal cord, where somatosensory information is processed. Dorsal horn neurons react to the rising input with heightened excitability, a process termed central sensitization. Enhanced depolarization leads to the recruitment of N-methyl-D-aspartate (NMDA)-type glutamate receptors. NMDA and neuropeptide receptor activation produces a sharp increase in intracellular calcium, triggering signaling pathways and gene expression changes that promote a long-term shift in the activity of nociceptive circuits. In some aspects, central sensitization even resembles long-term potentiation of excitatory transmission in the hippocampus. Central sensitization generates an exaggerated response to painful stimuli (hyperalgesia) and contributes to pain elicited by normally nonpainful stimuli (allodynia). Clinical findings suggest that pain hypersensitivity produces structural changes in the brain over time. These changes are, however, reversible upon pain relief. The pathophysiology of neuropathic pain is fundamentally different. Peripheral nerve lesion evokes stimulus-independent (ectopic) activity in nerve fibers. Innate immune cells react at the lesion site, in the dorsal root ganglion, where the cell bodies of peripheral somatosensory neurons reside, and in the dorsal horn of the spinal cord. Active microglia of the dorsal horn releases chemical mediators that modulate the activity of neurons in the vicinity. One of these mediators, brain-derived neurotrophic factor, reduces the inhibitory effect of γ-aminobutyric acid (GABA) and glycine. Disinhibition opens polysynaptic connections in the dorsal horn, further enhancing the abnormal input from the lesioned nerve. Similarly to nociceptive pain, central sensitization occurs. Worsened by a relative deficit in transmitter uptake, increased glutamatergic transmission causes excitotoxic cell death, reducing the number of inhibitory interneurons. Their loss and a shift in descending modulatory pathways from the brainstem produce a profound imbalance between inhibition and excitation. The complexity of chronic pain mechanisms poses a major therapeutic challenge. Without biomarkers, it will remain difficult to develop targeted strategies for chronic pain reduction or prevention in the individual patient. Disclosures: No conflict of interest.
Simulation of mirror inversion of quantum states in an XY spin chain using NMR
Creators: name: Rao, K. Rama Koteswara
name: Mahesh, T. S.
name: Kumar, Anil
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report an experimental quantum simulation of unitary dynamics of an XY spin chain with pre-engineered couplings. Using this simulation, we demonstrate the mirror inversion of quantum states, proposed by Albanese et al. [Phys. Rev. Lett. 93, 230502 (2004)]. The experiment is performed with a 5-qubit dipolar coupled spin system using nuclear magnetic resonance techniques. To perform quantum simulation we make use of the recently proposed unitary operator decomposition algorithm of Ajoy et al. [Phys. Rev. A 85, 030303 (2012)] along with numerical pulse optimization techniques. Further, using mirror inversion, we demonstrate that entangled states can be transferred from one end of the chain to the other end. The simulations are implemented with high experimental fidelity, which implies that these kind of simulations may be possible in larger systems.
description: 9 pages, 6 figures
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1
Creators: name: Rudd, Meghan
name: Mohamed, Hassan
name: Price, Jessica Caughman
name: O’Hara, Andrea
name: Le Gallo, Matthieu
name: Urick, Mary
name: Cruz, Pedro L.
name: Zhang, Suiyuan
name: Hansen, Nancy
name: Godwin, Andrew
name: Sgroi, Dennis
name: Wolfsberg, Tyra
name: Mullikin, James
name: Merino, Maria
name: Bell, Daphne
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Protein-tyrosine kinase
subject: Endometrium--Cancer
subject: Genetics
subject: FOS: Biological sciences

description: Background: Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clinically aggressive tumors for which alternative therapeutic approaches are needed. The purpose of this study was to search for somatic mutations in the tyrosine kinome of serous and clear cell ECs, because mutated kinases can point to potential therapeutic targets. Methods: In a mutation discovery screen, we PCR amplified and Sanger sequenced the exons encoding the catalytic domains of 86 tyrosine kinases from 24 serous, 11 clear cell, and 5 mixed histology ECs. For somatically mutated genes, we next sequenced the remaining coding exons from the 40 discovery screen tumors and sequenced all coding exons from another 72 ECs (10 clear cell, 21 serous, 41 endometrioid). We assessed the copy number of mutated kinases in this cohort of 112 tumors using quantitative real time PCR, and we used immunoblotting to measure expression of these kinases in endometrial cancer cell lines. Results: Overall, we identified somatic mutations in TNK2 (tyrosine kinase non-receptor, 2) and DDR1 (discoidin domain receptor tyrosine kinase 1) in 5.3% (6 of 112) and 2.7% (3 of 112) of ECs. Copy number gains of TNK2 and DDR1 were identified in another 4.5% and 0.9% of 112 cases respectively. Immunoblotting confirmed TNK2 and DDR1 expression in endometrial cancer cell lines. Three of five missense mutations in TNK2 and one of two missense mutations in DDR1 are predicted to impact protein function by two or more in silico algorithms. The TNK2P761Rfs*72 frameshift mutation was recurrent in EC, and the DDR1R570Q missense mutation was recurrent across tumor types. Conclusions: This is the first study to systematically search for mutations in the tyrosine kinome in clear cell endometrial tumors. Our findings indicate that high-frequency somatic mutations in the catalytic domains of the tyrosine kinome are rare in clear cell ECs. We uncovered ten new mutations in TNK2 and DDR1 within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.
Using the collaborative intervention planning framework to adapt a health-care manager intervention to a new population and provider group to improve the health of people with serious mental illness
Creators: name: Cabassa, Leopoldo J.
name: Gomes, Arminda
name: Meyreles, Quisqueya
name: Capitelli, Lucia
name: Younge, Richard G.
name: Dragatsi, Dianna
name: Alvarez, Juana
name: Manrique, Yamira
name: Lewis-Fernández, Roberto
Publisher: name: Columbia University
Year: 2014
Subjects: Community mental health services
Hispanic Americans--Services for
Mental health

description: Background: Health-care manager interventions improve the physical health of people with serious mental illness (SMI) and could be widely implemented in public mental health clinics. Local adaptations and customization may be needed to increase the reach of these interventions in the public mental health system and across different racial and ethnic communities. In this study, we describe how we used the collaborative intervention planning framework to customize an existing health-care manager intervention to a new patient population (Hispanics with SMI) and provider group (social workers) to increase its fit with our local community. Methods: The study was conducted in partnership with a public mental health clinic that serves predominantly Hispanic clients. A community advisory board (CAB) composed of researchers and potential implementers (e.g., social workers, primary care physicians) used the collaborative intervention planning framework, an approach that combines community-based participatory research principles and intervention mapping (IM) procedures, to inform intervention adaptations. Results: The adaptation process included four steps: fostering collaborations between CAB members; understanding the needs of the local population through a mixed-methods needs assessment, literature reviews, and group discussions; reviewing intervention objectives to identify targets for adaptation; and developing the adapted intervention. The application of this approach enabled the CAB to identify a series of cultural and provider level-adaptations without compromising the core elements of the original health-care manager intervention. Conclusions: Reducing health disparities in people with SMI requires community engagement, particularly when preparing existing interventions to be used with new communities, provider groups, and practice settings. Our study illustrates one approach that can be used to involve community stakeholders in the intervention adaptation process from the very beginning to enhance the transportability of a health-care manager intervention in order to improve the health of people with SMI.
Dactylomys boliviensis Anthony 1920
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Echimyidae
Dactylomys
Dactylomys boliviensis

description: Dactylomys boliviensis Anthony, 1920. J. Mammal., 1:82. TYPE LOCALITY: Bolivia, Cochabamba Dept., Mision de San Antonio. DISTRIBUTION: C. Bolivia; S.E. Peru. ISIS NUMBER: 5301410029012001001 as D. bolivensis (sic).
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 586, DOI: 10.5281/zenodo.7353039
Disputatio Physico-Moralis De Temperamento Primi Hominis In Statu Integritatis; [1709]
Creators: name: Werther, Georg Christian
name: Biel, Johannes
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Vorlageform des Erscheinungsvermerks: Lipsiæ, Typiis Immanuelis Titii.
Research results from a registry supporting efforts to improve maternal and child health in low and middle income countries
Creators: name: Goldenberg, Robert L.
name: McClure, Elizabeth M.
name: Bose, Carl L.
name: Jobe, Alan H.
name: Belizán, José M.
Publisher: name: Columbia University
Year: 2015
Subjects: Child health services
Maternal health services
Public health

description: The National Institute of Child Health and Human Development created and continues to support the Global Network for Women's and Children's Health Research, a partnership between research institutions in the US and low-middle income countries. This commentary describes a series of 15 papers emanating from the Global Network’s Maternal and Newborn Health Registry. Using data from 2010 to 2013, the series of papers describe
nearly 300,000 pregnancies in 7 sites in 6 countries – India (2 sites), Pakistan, Kenya, Zambia, Guatemala and Argentina. These papers cover a wide range of topics including several dealing with efforts made to ensure data quality, and others reporting on specific pregnancy outcomes including maternal mortality, stillbirth and neonatal mortality. Topics ranging from antenatal care, adolescent pregnancy, obstructed labor, factors associated with early initiation of breast feeding and maintenance of exclusive breast feeding and contraceptive usage are presented. In addition, case studies evaluating changes in mortality over time in 3 countries - India, Pakistan and Guatemala - are presented. In order to make progress in improving pregnancy outcomes in low-income countries, data of this quality are needed.
Construction of dynamics and time-ordered exponential for unbounded non-symmetric Hamiltonians
Creators: name: Futakuchi, Shinichiro
name: Usui, Kouta
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Functional Analysis (math.FA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We prove under certain assumptions that there exists a solution of the Schrodinger or the Heisenberg equation of motion generated by a linear operator H acting in some complex Hilbert space H, which may be unbounded, not symmetric, or not normal. We also prove that, under the same assumptions, there exists a time evolution operator in the interaction picture and that the evolution operator enjoys a useful series expansion formula. This expansion is considered to be one of the mathematically rigorous realizations of so called "time-ordered exponential", which is familiar in the physics literature. We apply the general theory to prove the existence of dynamics for the mathematical model of Quantum Electrodynamics (QED) quantized in the Lorenz gauge, the interaction Hamiltonian of which is not even symmetric or normal.
description: 41 pages
British Columbia Legislative Assembly sessional clipping book (1916-03)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
CONSPIRACY OFFENSES IN NIGERIA AND THE COMMONWEALTH: A COMPARATIVE ANALYSIS
Creators: name: Dr. Omote King, Osarenotor
Publisher: name: keith journal
Year: 2025
Subjects: Inchoate Offences, Conspiracy, English Law, Commonwealth Jurisdictions, Comparative Analysis

description: English law encompasses inchoate offences, crimes that address conduct before the full commission of a substantive crime. One such inchoate offence is conspiracy. This paper delves into the examination of conspiracy across three Commonwealth jurisdictions: Nigeria, India, and the Australian State of Queensland. The foundation for this exploration is the English legal system, the source of common law, given that these three jurisdictions base their legal systems on English common law principles. While the English legal system lays the groundwork, the analysis extends to the regulation of conspiracy in each jurisdiction. In Nigeria, the Penal Code and the Criminal Code govern this offence, while in India, the Indian Penal Code provides the legal framework. In the Australian State of Queensland, the Criminal Code of 1899, which influenced the Nigerian Criminal Code, serves as the guiding statute. This comparative analysis aims to shed light on the varying approaches to conspiracy in these Commonwealth jurisdictions and their alignment with English law principles.