cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Serological Response to Three, Four and Five Doses of SARS-CoV-2 Vaccine in Kidney Transplant Recipients
Creators: name: Osmanodja, Bilgin
name: Ronicke, Simon
name: Budde, Klemens
name: Jens, Annika
name: Hammett, Charlotte
name: Koch, Nadine
name: Seelow, Evelyn
name: Waiser, Johannes
name: Zukunft, Bianca
name: Bachmann, Friederike
name: Choi, Mira
name: Weber, Ulrike
name: Eberspächer, Bettina
name: Hofmann, Jörg
name: Grunow, Fritz
name: Mikhailov, Michael
name: Liefeldt, Lutz
name: Eckardt, Kai-Uwe
name: Halleck, Fabian
name: Schrezenmeier, Eva
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: kidney transplantation
subject: COVID-19
subject: vaccination
subject: immunosuppression
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mortality from COVID-19 among kidney transplant recipients (KTR) is high, and their response to three vaccinations against SARS-CoV-2 is strongly impaired. We retrospectively analyzed the serological response of up to five doses of the SARS-CoV-2 vaccine in KTR from 27 December 2020 until 31 December 2021. Particularly, the influence of the different dose adjustment regimens for mycophenolic acid (MPA) on serological response to fourth vaccination was analyzed. In total, 4277 vaccinations against SARS-CoV-2 in 1478 patients were analyzed. Serological response was 19.5% after 1203 basic immunizations, and increased to 29.4%, 55.6%, and 57.5% in response to 603 third, 250 fourth, and 40 fifth vaccinations, resulting in a cumulative response rate of 88.7%. In patients with calcineurin inhibitor and MPA maintenance immunosuppression, pausing MPA and adding 5 mg prednisolone equivalent before the fourth vaccination increased the serological response rate to 75% in comparison to the no dose adjustment (52%) or dose reduction (46%). Belatacept-treated patients had a response rate of 8.7% (4/46) after three vaccinations and 12.5% (3/25) after four vaccinations. Except for belatacept-treated patients, repeated SARS-CoV-2 vaccination of up to five times effectively induces serological response in kidney transplant recipients. It can be enhanced by pausing MPA at the time of vaccination.
title: Does dynamic volumetric CT angiography of endoleak after endovascular aortic aneurysm repair using 320-detector row CT add additional information with dynamic CT angiography?
Creators: name: Inoue, Masanori
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Vascular
subject: CT-Angiography
subject: Computer Applications-Detection, diagnosis
subject: Aneurysms

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Introduction Endovascular aneurysm repair (EVAR) has become established as a minimal invasive treatment of choice for abdominal aortic aneurysm (AAA) ; however, unlike open repair, it is essential after EVAR to perform lifelong imaging surveillance...
Late time behavior of non-conformal plasmas
Creators: name: Gursoy, Umut
name: Jarvinen, Matti
name: Policastro, Giuseppe
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We determine analytically the dependence of the approach to thermal equilibrium of strongly coupled plasmas on the breaking of scale invariance. The theories we consider are the holographic duals to Einstein gravity coupled to a scalar with an exponential potential. The coefficient in the exponent, $X$, is the parameter that controls the deviation from the conformally invariant case. For these models we obtain analytic solutions for the plasma expansion in the late-time limit, under the assumption of boost-invariance, and we determine the scaling behaviour of the energy density, pressure, and temperature as a function of time. We find that the temperature decays as a function of proper time as $T\sim τ^{-s/4}$ with $s$ determined in terms of the non-conformality parameter $X$ as $s=4(1-4X^2)/3$. This agrees with the result of Janik and Peschanski, $s=4/3$, for the conformal plasmas and generalizes it to non-conformal plasmas with $X\neq 0$. We also consider more realistic potentials where the exponential is supplemented by power-law terms. Even though in this case we cannot have exact solutions, we are able under certain assumptions to determine the scaling of the energy, that receives logarithmic corrections.
description: 31 pages
La fine del mondo.
Creators: name: Pazienti, Paola
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: Maurice Merleau-Ponty’s concept of the world could be intended, on the one hand, as a structure of horizon drawn around an individual or a social group, which can be declined into a plurality of “phenomena-of-the-world”, both real or virtual; on the other, as a primordial ground or “flesh of the world”, which re-proposes the metaphysical-theological question of the foundation. This essay attempts to provide an analysis of the dynamic of institution and sedimentation at the base of every cultural world and its exposure to the risk of “the end of the world”, as formulated by the Italian anthropologist Ernesto De Martino in his last and unfinished project about the possibility of psychopathological and cultural apocalypses. Our thesis is that Merleau-Ponty’s final phenomenological ontology, deployed in The Visible and the Invisible, receives new light from this interpretation, especially for what concerns the use of a mythical language in an indirect approach to Being.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
role of Poincaré’s study of the celestial mechanics in the development of Deleuze and Guattari’s chaosmological thinking
Creators: name: Beaulieu, Alain
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: This paper explores the way Henri Poincaré’s study of the dynamic movements of celestial bodies – which announces the theory of chaos – coheres with Deleuze and Guattari’s chaosmological thinking. The paper demonstrates how topics associated with chaos theory, including the limits of quantitative solutions, phenomena of orbital resonance, fractal attractors, and Poincaré’s conception of unsolvable problems, intermingle with Deleuze and Guattari’s philosophy. The paper supports the idea that the lines of interference between the new scientific study of chaos initiated by Poincaré, and a chaosmological thinking, are consistent within a partly undetermined universe, or chaosmos.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Multifractal characterization of gold market: a multifractal detrended fluctuation analysis
Creators: name: Mali, Provash
name: Mukhopadhyay, Amitabha
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Finance (q-fin.ST)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: The multifractal detrended fluctuation analysis technique is employed to analyze the time series of gold consumer price index (CPI) and the market trend of three world's highest gold consuming countries, namely China, India and Turkey for the period: 1993-July 2013. Various multifractal variables, such as the generalized Hurst exponent, the multifractal exponent and the singularity spectrum, are calculated and the results are fitted to the generalized binomial multifractal (GBM) series that consists of only two parameters. Special emphasis is given to identify the possible source(s) of multifractality in these series. Our analysis shows that the CPI series and all three market series are of multifractal nature. The origin of multifractality for the CPI time series and Indian market series is found due to a long-range time correlation, whereas it is mostly due to the fat-tailed probability distributions of the values for the Chinese and Turkey markets. The GBM model series more or less describes all the time series analyzed here.
description: 20 pages, 7 figures, 1 table
Impact evaluation of the Urban Health Initiative in urban Uttar Pradesh, India
Creators: name: Lance, Peter M.
name: Sengupta, Ranajit
name: Kebede, Essete
name: Calhoun, Lisa M.
name: Stewart, John F.
name: Achyut, Pranita
name: Speizer, Ilene S.
name: Benson, Aimee
name: Winston, Jennifer
name: Corroon, Meghan
name: Mishra, Anurag
name: Guilkey, David K.
name: Nanda, Priya
name: O'Hara, Rick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The Urban Health Initiative (UHI) was initiated in 2009 with the goal of increasing family planning (FP) use among the poor in urban areas of Uttar Pradesh, India. The Measurement, Learning & Evaluation project (MLE) was tasked with rigorous impact evaluation of the UHI. This paper presents the impact evaluation findings of the UHI program.
Assessment of Renal Transplant Perfusion by Contrast-Enhanced Ultrasound after Switch from Calcineurin Inhibitor to Belatacept: A Pilot Study
Creators: name: Osmanodja, Bilgin
name: Muench, Frédéric
name: Holderied, Alexander
name: Budde, Klemens
name: Fischer, Thomas
name: Lerchbaumer, Markus Herbert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: kidney transplantation
subject: calcineurin inhibitors
subject: ultrasonography
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Calcineurin inhibitors (CNIs) have improved short-term kidney allograft survival but are nephrotoxic and vasoconstrictive. Vasoconstriction is potentially reversible after switching from CNIs to belatacept. The kidney allograft shows optimal requirements for dynamic perfusion imaging using contrast-enhanced ultrasound (CEUS). We performed standardized CEUS in patients after switching from CNIs to belatacept for clinical indication to study the suitability of CEUS, in order to assess the effects of CNI cessation on kidney allograft perfusion. Eleven kidney transplant patients were enrolled from February 2020 until November 2020. Demographic, clinical, and laboratory parameters, as well as perfusion imaging, were assessed at baseline and 6 months after switching immunosuppression. Quantification of perfusion imaging on CEUS was performed using a post-processing software tool on uncompressed DICOM cine loops. After CNI cessation, estimated glomerular filtration rate increased by 4.8 mL/min/1.73 m(2) (16%). Despite good quality of fit and comparable regions of interest in baseline and follow-up CEUS examinations, quantification of perfusion imaging showed a slightly improved cortical perfusion without reaching statistical significance after CNI cessation. This is the first study that systematically investigates the suitability of CEUS to detect changes of microvascular perfusion in kidney transplant recipients in vivo. No significant differences could be detected in perfusion measurements before and after CNI cessation.
Can heterotrophic uptake of dissolved organic carbon and zooplankton mitigate carbon budget deficits in annually bleached corals?
Creators: name: Grottoli, Andréa G.
name: Bauer, James E.
name: Aschaffenburg, Matthew
name: Schoepf, Verena
name: Baumann, Justin
name: Warner, Mark E.
name: Levas, Stephen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Annual coral bleaching events due to increasing sea surface temperatures are predicted to occur globally by the mid-century and as early as 2025 in the Caribbean, and severely impact coral reefs. We hypothesize that heterotrophic carbon (C) in the form of zooplankton and dissolved organic carbon (DOC) is a significant source of C to bleached corals. Thus, the ability to utilize multiple pools of fixed carbon and/or increase the amount of fixed carbon acquired from one or more pools of fixed carbon (defined here as heterotrophic plasticity) could underlie coral acclimatization and persistence under future ocean-warming scenarios. Here, three species of Caribbean coral—Porites divaricata, P. astreoides, and Orbicella faveolata—were experimentally bleached for 2.5 weeks in two successive years and allowed to recover in the field. Zooplankton feeding was assessed after single and repeat bleaching, while DOC fluxes and the contribution of DOC to the total C budget were determined after single bleaching, 11 months on the reef, and repeat bleaching. Zooplankton was a large C source for P. astreoides, but only following single bleaching. DOC was a source of C for single-bleached corals and accounted for 11–36 % of daily metabolic demand (CHARDOC), but represented a net loss of C in repeat-bleached corals. In repeat-bleached corals, DOC loss exacerbated the negative C budgets in all three species. Thus, the capacity for heterotrophic plasticity in corals is compromised under annual bleaching, and heterotrophic uptake of DOC and zooplankton does not mitigate C budget deficits in annually bleached corals. Overall, these findings suggest that some Caribbean corals may be more susceptible to repeat bleaching than to single bleaching due to a lack of heterotrophic plasticity, and coral persistence under increasing bleaching frequency may ultimately depend on other factors such as energy reserves and symbiont shuffling.
Declining Course of Humoral Immune Response in Initially Responding Kidney Transplant Recipients after Repeated SARS-CoV-2 Vaccination
Creators: name: Ronicke, Simon
name: Osmanodja, Bilgin
name: Budde, Klemens
name: Jens, Annika
name: Hammett, Charlotte
name: Koch, Nadine
name: Zukunft, Bianca
name: Bachmann, Friederike
name: Choi, Mira
name: Weber, Ulrike
name: Eberspächer, Bettina
name: Hofmann, Jörg
name: Grunow, Fritz
name: Mikhailov, Michael
name: Halleck, Fabian
name: Schrezenmeier, Eva
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: SARS-CoV-2
subject: COVID-19
subject: vaccination
subject: immunogenicity
subject: kidney transplantation
subject: immunosuppression
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The immunogenicity of SARS-CoV-2 vaccines in kidney transplant recipients is limited, resulting in inadequately low serological response rates and low immunoglobulin (Ig) levels, correlating with reduced protection against death and hospitalization from COVID-19. We retrospectively examined the time course of anti-SARS-CoV-2 Ig antibody levels after up to five repeated vaccinations in 644 previously nonresponding kidney transplant recipients. Using anti SARS-CoV-2 IgG/IgA ELISA and the total Ig ECLIA assays, we compared antibody levels at 1 month with levels at 2 and 4 months, respectively. Additionally, we correlated the measurements of the used assays. Between 1 and 2 months, and between 1 and 4 months, mean anti-SARS-CoV-2 Ig levels in responders decreased by 14% and 25%, respectively, depending on the assay. Absolute Ig values and time course of antibody levels showed high interindividual variability. Ig levels decreased by at least 20% in 77 of 148 paired samples with loss of sufficient serological protection over time occurring in 18 out of 148 (12.2%). IgG ELISA and total Ig ECLIA assays showed a strong positive correlation (Kendall's tau = 0.78), yet the two assays determined divergent results in 99 of 751 (13.2%) measurements. IgG and IgA assays showed overall strong correlation but divergent results in 270 of 1.173 (23.0%) cases and only weak correlation of antibody levels in positive samples. Large interindividual variability and significant loss of serological response after 4 months supports repeated serological sampling and consideration of shorter vaccination intervals in kidney transplant recipients.
title: Assessment of diagnostic low dose CT chest protocols in the province of Nova Scotia
Creators: name: Tonkopi, Elena
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Thorax
subject: CT
subject: Dosimetry

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The aim of this study was to evaluate diagnostic low dose chest (LDC) CT protocols in the province and to identify hospital sites which require protocol optimization. Radiologic examinations represent the largest and most rapidly growing man-made...
Come il cosmo finì per diventare abisso: horror fati e rottura rivoluzionaria nella lettura benjaminiana dell’Eternité par les astres di Blanqui
Creators: name: Nutini, Anna
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The concept of the cosmos presents itself as an aseptic construct when used in the scientific sphere, or refers to a chimerical metaphysical speculation detached from reality and therefore seemingly harmless. Instead, it contains an irreducible political character. The encounter with Blanqui's Eternité par les astres allows Benjamin to explore the relationship between the transformations of society within advanced capitalism and the cosmic doctrines that accompanied them. In Blanqui's writing, in particular, the cosmos becomes the screen onto which the capitalist fair of repetition is projected. The universe thus becomes an immense showcase and the stars that populate it are transformed into a crowd of commodities whose apparent novelty imprisons the masses in an obsessive spell. Behind the celebration of progress, supported by the perennial spectacle of consumption, Blanqui glimpses, by contrast, the repetition that leads towards catastrophe. The cosmos is revealed to be sustained by an infernal cycle that leads it to sink towards the abyss. In Benjamin's later works, the critique of the positivist doctrine of progress and the Nietzschean doctrine of the eternal return finds a decisive foothold in Blanqui's cosmic sentence. At the same time, however, Benjamin recognises the surrender that closes Blanqui's work as a further bewitching phantasmagoria to which it is necessary to react by unlocking the revolutionary chance that dwells in every moment of history. The concept of revolution itself is thus rethought by Benjamin through the original recovery of the link that this term has with the sphere of astronomy.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Fuzzy dark matter constraints from a single VLBI observation of a gravitationally lensed radio jet
Creators: name: Powell, Devon
Publisher: name: Zenodo
Year: 2023

description: Strong gravitational lensing by galaxies provides us with a powerful laboratory for testing dark matter models. Various particle models for dark matter give rise to different small-scale distributions of mass in the lens galaxy, which can be differentiated if the observation is sensitive enough. The sensitivity of a gravitational lens observation to the presence (or absence) of low-mass dark structures in the lens galaxy is determined mainly by the angular resolution of the instrument and the spatial structure of the source.
 In this talk, I will present results from the analysis of a global VLBI observation of a gravitationally lensed radio jet. With an angular resolution better than 5 milli-arcseconds and a highly extended, spatially resolved arc, we are able to place competitive constraints on the particle mass in fuzzy dark matter models using this single observation. I will also present preliminary results from our analysis of warm dark matter models using this lens system. Our results illustrate the key role that VLBI observations will play in revealing the nature of dark matter, especially in light of the ~10^5 gravitational lens systems with radio-bright sources which will be discovered by the Square Kilometre Array.
How “Neuronal” Are Human Skin Mast Cells?
Creators: name: Babina, Magda
name: Franke, Kristin
name: Bal, Gürkan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: mast cells
subject: neurons
subject: degranulation
subject: dopamine
subject: adhesion molecules
subject: solute carriers
subject: calbindin
subject: transcription factors
subject: skin
subject: monoamine oxidase B
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mast cells are evolutionarily old cells and the principal effectors in allergic responses and inflammation. They are seeded from the yolk sac during embryogenesis or are derived from hematopoietic progenitors and are therefore related to other leukocyte subsets, even though they form a separate clade in the hematopoietic system. Herein, we systematically bundle information from several recent high-throughput endeavors, especially those comparing MCs with other cell types, and combine such information with knowledge on the genes' functions to reveal groups of neuronal markers specifically expressed by MCs. We focus on recent advances made regarding human tissue MCs, but also refer to studies in mice. In broad terms, genes hyper-expressed in MCs, but largely inactive in other myelocytes, can be classified into subcategories such as traffic/lysosomes (MLPH and RAB27B), the dopamine system (MAOB, DRD2, SLC6A3, and SLC18A2), Ca2+-related entities (CALB2), adhesion molecules (L1CAM and NTM) and, as an overall principle, the transcription factors and modulators of transcriptional activity (LMO4, PBX1, MEIS2, and EHMT2). Their function in MCs is generally unknown but may tentatively be deduced by comparison with other systems. MCs share functions with the nervous system, as they express typical neurotransmitters (histamine and serotonin) and a degranulation machinery that shares features with the neuronal apparatus at the synapse. Therefore, selective overlaps are plausible, and they further highlight the uniqueness of MCs within the myeloid system, as well as when compared with basophils. Apart from investigating their functional implications in MCs, a key question is whether their expression in the lineage is due to the specific reactivation of genes normally silenced in leukocytes or whether the genes are not switched off during mastocytic development from early progenitors.
Non-Abelian Binding Energies from the Lightcone Bootstrap
Creators: name: Li, Daliang
name: Meltzer, David
name: Poland, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analytically study the lightcone limit of the conformal bootstrap for 4-point functions containing scalars charged under global symmetries. We show the existence of large spin double-twist operators in various representations of the global symmetry group. We then compute their anomalous dimensions in terms of the central charge $C_T$, current central charge $C_J$, and the OPE coefficients of low dimension scalars. In AdS, these results correspond to the binding energy of two-particle states arising from the exchange of gravitons, gauge bosons, and light scalar fields. Using unitarity and crossing symmetry, we show that gravity is universal and attractive among different types of two-particle states, while the gauge binding energy can have either sign as determined by the representation of the two-particle state, with universal ratios fixed by the symmetry group. We apply our results to 4D $\mathcal{N}=1$ SQCD and the 3D O(N) vector models. We also show that in a unitary CFT, if the current central charge $C_J$ stays finite when the global symmetry group becomes infinitely large, such as the $N\rightarrow\infty$ limit of the O(N) vector model, then the theory must contain an infinite number of higher spin currents.
description: Added comments on the weak gravity conjecture
Gravitational lensing in the age of the ILT and SKA-VLBI
Creators: name: McKean, John
Publisher: name: Zenodo
Year: 2023

description: The first VLBI observations of strong gravitational lensing were reported about 44 years ago, and since then, the field has grown to become an important tool for studying galaxy formation, dark matter and the distant Universe at the highest angular resolutions possible in astronomy. Unfortunately, only a handful of radio-bright lenses are known, identified mainly from the first systematic lens surveys and some serendipitous discoveries over the last four decades. However, this is set to change with the large area all-sky surveys being carried out now with the Low Frequency Array (LOFAR) and with the Square Kilometre Array (SKA) in the future, which will discover tens of thousands of new systems. Here, we present the first results from observations of known gravitational lenses with LOFAR and the new discoveries being made with the International LOFAR Telescope (ILT). For the latter, we will present a novel machine-learning based method for identifying lenses with the ILT, from which, we have determined the types of lenses that the ILT is likely to find. We will show the first results from applying this and standard catalogue-based searches for lenses in the first batch of data from the ILT, and will present the first set of new lens candidates to be identified with LOFAR. Finally, we will discuss the prospects for lens discovery with the SKA and the importance of having a VLBI array within Africa for realising the unique science cases that are only possible with strong gravitational lensing.
title: Radiation dose reduction on lens and thyroid in orthopantomography exams
Creators: name: Pinheiro, Joao
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Radioprotection / Radiation dose
subject: Professional issues
subject: Conventional radiography
subject: Digital radiography
subject: Technical aspects
subject: Radiation safety
subject: Health policy and practice
subject: Occupational / Environmental hazards
subject: Dosimetric comparison
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Measure entrance surface dose into the crystalline, thyroid and body, in an anthropomorphic phantom, in panoramic radiography exams. Check the efficiency of radiological protections, and compare to the diagnostic reference levels and other...
The Association Between the MAOA 2R Genotype and Delinquency Over Time Among Men: The Interactive Role of Parental Closeness and Parental Incarceration
Creators: name: Boardman, Jason D.
name: Guo, Guang
name: Roettger, Michael E.
name: Harris, Kathleen Mullan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Using a panel of 6,001 males from the National Longitudinal Study of Adolescent and Adult Health, we examine potential moderation by paternal incarceration and parent-child closeness altering the relationship between the rare 2R MAOA genotype and delinquency. By jointly examining moderation patterns for both the mother and father with the transmission of the MAOA genotype from mother to son, we are able to make inferences about the specific genetic model that best explains these outcomes. In line with prior research, we find a direct relationship between the MAOA 2R genotype and delinquency, independent of parental incarceration and closeness. Examining moderation patterns, we find that delinquency risk for the 2R allele is buffered for males close to their biological or social father, but not their biological mother. We conclude that the 2R delinquency association is not due to passive gene-environment correlation but is best characterized as a social control gene-environment interaction.
title: 3T MR spectroscopy in the multi-parametric MRI evaluation of breast lesions: a pattern recognition approach
Creators: name: Cavedon, Carlo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: MR-Spectroscopy
subject: MR-Diffusion/Perfusion
subject: MR
subject: Computer Applications-Detection, diagnosis
subject: Diagnostic procedure
subject: Decision analysis
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To assess the role of 3T-MR spectroscopy (MRS) in the multi-parametric MRI evaluation of breast lesions, using a pattern recognition...
La problematica natura onto-teologica del cosmo in Numenio di Apamea
Creators: name: Volpe, Enrico
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The metaphysical system of Numenius of Apamea is structured according to an onto-theological hierarchy, which presents three levels of reality that Numenius calls “Gods”. Even though the role of the first and the second God is of paramount importance in the metaphysics of Numenius, the third God, which is also defined “cosmos”, has a troublesome ontological status. According to Numenius, the cosmos has “dianoetic thought” since his nature derives from the “encounter” of two metaphysical principles, the demiurge, and the matter. My investigation starts from the testimony of Proclus and then it focuses on Eusebius' Praeparatio Evangelica, in which he quotes directly some passages from the work on Numenius On the Good. My goal in this article is to show that Numenius conceives of the third God not as the cosmos in a material sense, but rather as the rational principle which rules the universe. In this respect, the discursive intellect and the divine nature of the cosmos seem to fit well together. The main question, however, concerns the possibility that Numenius understands the presence (or the identification) of the cosmos with a World Soul. My purpose is to show that even though Numenius does not define the third God explicitly as a “Soul”, its rational principle works as a Soul. Finally, I try to show that this conception of third God by Numenius lays the ground for the Plotinian concept of the Third Hypostasis.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Il sole al tramonto
Creators: name: Chiaravalli, Iacopo
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The essay aims to show the importance of Brecht’s theory of epic theatre for Benjamin’s reshape of historical cognition in On the Concept of History. Brecht’s influence on Benjamin is usually restricted to works such as The Author as Producer or The Work of Art in the Age of Its Technological Reproducibility. On the contrary, I argue that Benjamin makes use of typical Brechtian elements in strategic conceptual passages of his challenging new version of the historical knowledge. This situation can be evident, like in Thesis VII where Benjamin assimilates Brecht’s critics against the Einfühlung as core of the traditional theatre. Otherwise, we find Brechtian references in other central passages. The most important is Thesis III where Benjamin articulates Brecht’s concept of citation as a way to rethink the relation between the present and the past. The citation of gesture in Brecht’s theatre points out the possibility to free an element from its starting condition. In this sense, Brechtian citation could be taken as a model for a free relationship with the tradition. In Brecht’s strategy Benjamin discovers the elements for a new concept of history. The article ends pointing out the structural difference between Benjamin and Brecht on the notion of interruption as source of the dialectical understanding of historical reality.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection
Creators: name: Bastarache, Julie A.
name: Rondina, Matthew T.
name: Mackman, Nigel
name: Tatsumi, Kohei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: To identify plasma biomarkers that can be early predictors of mortality in critically ill patients with primary influenza A/H1N1.
Cell-Type Specific Inhibition Controls the High-Frequency Oscillations in the Medial Entorhinal Cortex
Creators: name: Gurgenidze, Shalva
name: Bäuerle, Peter
name: Schmitz, Dietmar
name: Vida, Imre
name: Gloveli, Tengis
name: Dugladze, Tamar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: inhibitory synaptic transmission
subject: opioid signaling
subject: cortical microcircuits
subject: oscillatory network activity
subject: interneurons
subject: pyramidal cells
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The medial entorhinal cortex (mEC) plays a critical role for spatial navigation and memory. While many studies have investigated the principal neurons within the entorhinal cortex, much less is known about the inhibitory circuitries within this structure. Here, we describe for the first time in the mEC a subset of parvalbumin-positive (PV+) interneurons (INs)-stuttering cells (STUT)-with morphological, intrinsic electrophysiological, and synaptic properties distinct from fast-spiking PV+ INs. In contrast to the fast-spiking PV+ INs, the axon of the STUT INs also terminated in layer 3 and showed subthreshold membrane oscillations at gamma frequencies. Whereas the synaptic output of the STUT INs was only weakly reduced by a mu-opioid agonist, their inhibitory inputs were strongly suppressed. Given these properties, STUT are ideally suited to entrain gamma activity in the pyramidal cell population of the mEC. We propose that activation of the mu-opioid receptors decreases the GABA release from the PV+ INs onto the STUT, resulting in disinhibition of the STUT cell population and the consequent increase in network gamma power. We therefore suggest that the opioid system plays a critical role, mediated by STUT INs, in the neural signaling and oscillatory network activity within the mEC.
title: Can MRI features before and after neoadjuvant chemotherapy predict surgical margins?
Creators: name: zhao, qiufeng
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: MR
subject: Treatment effects
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Neoadjuvant chemotherapy (NAC) is currently considered for nearly all breast cancer patients who will require adjuvant systemic chemotherapy (1).Theadvantages of NAC include the possibilities of increasing eligibility rates for breast-conserving...
Il mondo locale: l’esperienza dell’osservatore fra fisica relativistica e neuroscienze
Creators: name: Laino, Luigi
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: In this paper, I have defended a transcendental interpretation of the concept of «world» in relativity theory. I have shown that despite the objectification implied by the unification of space and time (section one), subjective conditions are still relevant for the construction of spacetime. Therefore, I have tackled Weyl’s and Eddington’s interpretations of relativity in the second section. Weyl, influenced by Husserl, endorsed the vision that local reality is built via the temporal form of consciousness. Although with less famous philosophical references, Eddington peculiarly sided with idealistic trends. He defined the physical world as the description of events or objects from the standpoint of no one in particular. Therefore, world-geometry, that is, spacetime diagrams and the geometry adopted in relativity, is conceived regardless of its actualizations. However, it turned out that the mind imposes its demands (such as permanence or contiguity) on the physical world and that measurements set up particular conditions. Finally, I have tried to revise these statements in light of the contemporary debate in the philosophy of physics and neuroscience. I have shown that the world, conceived of as local reality, should be studied by combining assumptions on the nature of the mind or brain with the physical properties of signals.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
The challenge of relativistic cosmology to describe the universe
Creators: name: Schettino, Giulia
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The search for a theory capable to describe the origin, the evolution and the structure of the universe is a long-standing issue. Recently, experimental cosmology has reached an astonishing accuracy. Nevertheless, a comprehensive theory of the universe has not been entirely formulated and developed thus far. Cosmology as an experimental science has to face unique challenges, due to the inaccessibility of the phenomena and processes under study and to the impossibility to reproduce them in a laboratory. These limits entail an extensive use of computer simulations, which become a fundamental tool of investigation, allowing to confront theoretical models and observations. This background arouses an intriguing philosophical debate concerning the inferential power of simulations in cosmology and their epistemic role. This paper reviews the cornerstones of relativistic cosmology and of the main alternative proposals to relativity and proposes some considerations on the contribution that philosophy of cosmology can provide to the contemporary debate in cosmology.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
La vita divina degli astri. Cosmologia e fisica in Giordano Bruno
Creators: name: Del Prete, Antonella
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The aim of this paper is to investigate Bruno’s astrobiology. The life of the stars can help us to highlight the characteristics of the infinite universe and to determine what relationship it has with God. Deeply hostile to Christianity, Bruno in fact holds that God and the world are inseparable. The ineffability of divinity can never be separated from its explication in the infinite universe. Human beings can find their place among the infinite worlds if they are able to understand that the universe is the unique nature, the true intermediary with God. Bruno enhances the capacities of the frenzied hero, without ever yielding to the temptation of anthropocentrism.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Universality and quantized response in bosonic nonfractionalized tunneling
Creators: name: Yin, Shaoyu
name: Béri, Benjamin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that tunneling involving bosonic wires and/or boson integer quantum Hall (bIQH) edges is characterized by universal features which are absent in their fermionic counterparts. Considering a pair of minimal geometries, we find a low energy enhancement and a universal high versus zero energy relation for the tunnel conductance that holds for all wire/bIQH edge combinations. Features distinguishing bIQH edges include a current imbalance to chemical potential bias ratio that is quantized despite the lack of conductance quantization in the bIQH edges themselves. The predicted phenomena require only initial states to be thermal and thus are well suited for tests with ultracold bosons forming wires and bIQH states. For the latter, we highlight a potential realization based on single component bosons in the recently observed Harper-Hofstadter bandstructure.
Implementing Electronic Tablet-Based Education of Acute Care Patients
Creators: name: Sawyer, Tenita
name: Nelson, Monica J.
name: Bowers, Margaret T.
name: Brewer, Cheryl
name: Abernethy, Amy
name: Meggitt, Corilin
name: Locke, Susan C.
name: Washington, Delphine
name: Gilliss, Catherine L.
name: Saladino, Louise
name: Baxt, Sarah K.
name: Granger, Bradi B.
name: Lehman, E. Philip
name: McKee, Vickie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Poor education-related discharge preparedness for patients with heart failure is believed to be a major cause of avoidable rehospitalizations. Technology-based applications offer innovative educational approaches that may improve educational readiness for patients in both inpatient and outpatient settings; however, a number of challenges exist when implementing electronic devices in the clinical setting. Implementation challenges include processes for "on-boarding" staff, mediating risks of cross-contamination with patients' device use, and selling the value to staff and health system leaders to secure the investment in software, hardware, and system support infrastructure. Strategies to address these challenges are poorly described in the literature. The purpose of this article is to present a staff development program designed to overcome challenges in implementing an electronic, tablet-based education program for patients with heart failure.
Galileons as the Scalar Analogue of General Relativity
Creators: name: Klein, Remko
name: Ozkan, Mehmet
name: Roest, Diederik
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We establish a correspondence between general relativity with diffeomorphism invariance and scalar field theories with Galilean invariance: notions such as the Levi-Civita connection and the Riemann tensor have a Galilean counterpart. This suggests Galilean theories as the unique nontrivial alternative to gauge theories (including general relativity). Moreover, it is shown that the requirement of first-order Palatini formalism uniquely determines the Galileon models with second-order field equations, similar to the Lovelock gravity theories. Possible extensions are discussed.
description: 6 pages, v2: Version appeared in Phys. Rev. D
title: Contrast enhanced ultrasound in axillary sentinel node assessment: does risk stratification improve yield
Creators: name: Larkman, Neal
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Interventional non-vascular
subject: Contrast agents
subject: Ultrasound
subject: Contrast agent-other
subject: Localisation
subject: Efficacy studies
subject: Outcomes
subject: Cancer
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Contrast enhanced ultrasound (CEUS) of the axilla is a developing technique which could reduce the need for two stage axillary surgical operations. It has been shown to have a sensitivity of 61% and specificity of 100% in a recent study (1). The...
Eriugena on the eternity and creation of the world
Creators: name: Wade, Maxwell
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: John Scotus Eriugena devotes a substantial portion of his Periphyseon to a longstanding cosmological question of whether the cosmos is eternal or created at a moment in time. This paper explores his examination of the question in light of the broader history of cosmology, as he straddles both antiquity and the Middle Ages by trying to integrate a Platonic ontology within a particular Christian framework. As a result, Eriugena produces a highly original solution to the debate that has been hitherto neglected in the broader conversation on this question. Finally, the paper situates this within Eriugena’s broader philosophical system and its significance in relation to his methodological approach.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
title: Accuracy and time-efficiency of an automated software tool to assess left ventricular volumes in cardiac MRI
Creators: name: Bastarrika Alemañ, Gorka
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: MR
subject: Comparative studies
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To assess the accuracy, reliability and time-efficiency of a recently commercialized fully automated left ventricular (LV) segmentation software tool to calculate LV volumes and function compared with conventional manual...
Joining Forces for Cancer Treatment: From “TCR versus CAR” to “TCR and CAR”
Creators: name: Teppert, Karin
name: Wang, Xueting
name: Anders, Kathleen
name: Evaristo, César
name: Lock, Dominik
name: Künkele, Annette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: immunotherapy
subject: tumor immunology
subject: adoptive T cell therapies
subject: immune synapse
subject: signaling
subject: endosomal trafficking
subject: T cell engineering
subject: chimeric antigen receptor
subject: T cell receptor
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: T cell-based immunotherapy has demonstrated great therapeutic potential in recent decades, on the one hand, by using tumor-infiltrating lymphocytes (TILs) and, on the other hand, by engineering T cells to obtain anti-tumor specificities through the introduction of either engineered T cell receptors (TCRs) or chimeric antigen receptors (CARs). Given the distinct design of both receptors and the type of antigen that is encountered, the requirements for proper antigen engagement and downstream signal transduction by TCRs and CARs differ. Synapse formation and signal transduction of CAR T cells, despite further refinement of CAR T cell designs, still do not fully recapitulate that of TCR T cells and might limit CAR T cell persistence and functionality. Thus, deep knowledge about the molecular differences in CAR and TCR T cell signaling would greatly advance the further optimization of CAR designs and elucidate under which circumstances a combination of both receptors would improve the functionality of T cells for cancer treatment. Herein, we provide a comprehensive review about similarities and differences by directly comparing the architecture, synapse formation and signaling of TCRs and CARs, highlighting the knowns and unknowns. In the second part of the review, we discuss the current status of combining CAR and TCR technologies, encouraging a change in perspective from "TCR versus CAR" to "TCR and CAR".