The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D for the potential Symptom Reducer, Prevention and Treatment for Coronavirus Disease 2019 (COVID-19)
Creators: name: Orzechowski, Michelle
name: Ahmed, Amr
name: Elkazzaz, Mahmoud
name: Al.Katten, Abdullah
Publisher: name: figshare
Year: 2021
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110799 Immunology not elsewhere classified
subject: FOS: Clinical medicine
subject: 30104 Immunological and Bioassay Methods
subject: FOS: Chemical sciences
subject: 110705 Humoural Immunology and Immunochemistry
subject: 110702 Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
subject: 110704 Cellular Immunology
subject: 30105 Instrumental Methods (excl. Immunological and Bioassay Methods)

description: Hypotheses:<br>The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D when taken together may Inhibit the Viral Replication of Anti-Cytokine Storm and an Antiviral against RNA Viruses like Coronavirus Disease 2019 (COVID-19) by using the formulations including Zinc; Zinc Ionophores (Quercetin); Bromelain, EGCG, Retinoic Acid, Vitamin C and Vitamin D. Zinc Ionophores possibly enhance transport of Zinc into the Cells to effect Intra-Cellular Zinc levels and potentially impair intracellular replication of Coronavirus Disease 2019 (COVID-19). [12]<br>Zinc regulates Adaptive Immune Cell Functions with High levels of Intracellular pH as RNA-dependent and RNA polymerase decreases the replication of RNA viruses like COVID-19. Quercetin has chelate Zinc Ions and act as a Zinc Ionophore.<br>Bromelain activates Natural Killer Cells and production of Granulocyte Macrophage Colony Stimulating Factor, Interleukin-2 and Interleukin-6 decreases the activation of T-helper Cells. <br>EGCG can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2, which mediate cell entry of the virus.<br>Retinoic Acid has a characteristic of antiviral, Immunity induction, ACE2 upregulation or downregulation and anti-clotting. <br>Vitamin C has Enzymatic Co-Factor for Hormone Production, Collagen Synthesis and Immune Potentiation.<br>Vitamin D regulates the Inflammatory Cytokine Response. Vitamin D deficiency has been associated with increased COVID-19 mortality and is commonly confounded by increasing age, obesity, diabetes, darker skin tones, and lack of fitness.<br>Introduction:Zinc alone is a potent inhibitor of viral replication. Zinc in combination of Quercetin potentially synergistic in reducing viral replication since Quercetin is potentially a Zinc Ionophore facilitating intracellular entry and inhibition of intracellular viral replication.Zinc in combination of Quercetin can access the DNA cellular layer and stop SARS-CoV-2 from replicating RNA cells, potentially resetting replicated cells, Treating the Coronavirus disease 2019 (COVID-19). Quercetin 800 mg, bromelain 165 mg, zinc acetate 50 mg and ascorbic acid 1 g once daily as supplements for 3 to 5 days were safe for patients infected with SARS-CoV-2 and may prevent poor prognosis through restraining from hyper-inflammation and cytokine storm. Randomized clinical trials are needed in the future to ensure the efficacy of quercetin, bromelain, zinc and ascorbic acid combination. [11.2]The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D should immediately be approved by the FDA as a Symptom Reducer and possible Prevention and Treatment for COVID-19. Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D are currently available over the counter and easily accessible without a prescription, The Combination of in addition to proper PPE and the FDA approved COVID-19 vaccination. The FDA recommended doses for Zinc, Vitamin C and Vitamin D; and Quercetin, Bromelain, EGCG and Retinoic Acid doses be suggested by the FDA. The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D should be approved as a Symptom Reducer for Coronavirus Disease 2019 (COVID-19) to provide over the counter relief for Coronavirus Disease 2019 (COVID-19) [14]On 09/30/2021 The Center for Biologics Evaluation and Research Vaccines and Related Biological Products Advisory Committee will meet. [15]The pathogen, a novel coronavirus (SARS-CoV-2), was identified by local hospitals using a surveillance mechanism for “pneumonia of unknown etiology” that was established in the wake of the 2003 SARS outbreak with the aim of allowing timely identification of novel pathogens. The immune system plays a critical role in protecting the human body from infectious diseases. T-cell counts are reduced significantly in COVID-19 patients, and the surviving T-cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μ L may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition. Further research on the severity of comorbidities and all medication received by the patients is mandatory to shed light on these associations. [11]Significance: The Over the Counter use of Quercetin and Bromelain is available for ages Two Years Old and older at a Maximum Suggested Dose of: Quercetin 800 mg, and Bromelain 200 mg. [6.3] [7.5]Conclusion: Over the Counter Quercetin 800 mg QD, Bromelain 200 mg QD, Zinc 11mg QD, Vitamin A 900 mcg QD, Vitamin C 90 mg QD and Vitamin D 20 mcg QD taken in combination together with Green Tea is potentially safe together for reducing the severity of symptoms in COVID-19 infection from ages Two Years Old and Older. The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D might help reduce the COVID-19 vaccine symptoms and would potentially be a promising addition to proper PPE with COVID-19 Vaccinations to help combat the fight on Coronavirus Disease 2019 (COVID-19).As a prescription is not needed, this combination is available online and in stores around the world. <br><br>