cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization of PRA2 and VAP-A, two regulators of protein trafficking between the endoplasmic reticulum and Golgi compartments
Creators: name: Gougeon, Pierre-Yves
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Neuroscience.

description: Regulation of vesicle trafficking is required to maintain the specific make-up of each membrane compartment. Prenylated Rab acceptor 1 (PRA1) is known to interact with Rab GTPases and VAMP2, proteins involved in vesicle trafficking, suggesting PRA isoforms could regulate vesicle trafficking. The first aim was to characterize PRA's interaction with Rabs and VAMP2. Using point mutations and in vitro binding assays, I discovered that PRAs interact with multiple Rabs independent of their guanine nucleotide-bound state and identified three residues (N70, S76, H166), whose mutation induced a strong modification to PRA1's interaction with both Rab3A and VAMP2. These results suggest PRA might employ the same binding site to interact with multiple proteins. The second aim was to identify novel PRA-interacting proteins and clarify the function of PRAs. I initiated a yeast two-hybrid screen with PRA1 as bait, and identified VAMP-associated protein A (VAP-A), a protein also believed to be involved in vesicle trafficking. In CHO cells, VAP-A extensively co-localized with the ER-localized PRA2 rather than the predominantly Golgi-localized PRA1, and co-immunoprecipitation confirmed the in vivo PRA2-VAP-A interaction. In immunofluorescence and biochemical assays, overexpression of VAP-A or PRA2 delayed the ER-to-Golgi trafficking of the secretory pathway marker VSVGts045. Also, FRAP assays demonstrated that unlike PRA2, VAP-A achieved this by inhibiting the ER-lateral movement of VSVG ts045, thereby delaying the protein's exit from the ER. ER budding assays confirmed that VAP-A overexpression reduced VSVGts045 sequestration onto vesicles. The addition of the microtubule-depolymerizing agent nocodazole rescued the VAP-A-induced reduction in VSVGts045 budding. This suggests that VAP-A creates static subcompartments of the ER via its interaction with microtubules preventing the lateral movement of VSVG ts045. Overexpression of PRA2 also reduced the levels of VSVG ts045 found on vesicles collected in the budding assay, and unexpectedly, microtubule depolymerization resulted in a doubling of VSVGts045 release from the ER. This suggests PRA2 overexpression has two effects: PRA2 can increase vesicle formation from the ER, but only when its dominant microtubule-dependent inhibitory effect is alleviated by microtubule depolymerization. The results I obtained suggest that both PRA2 and VAP-A delay the ER-to-Golgi trafficking of VSVGts045, but achieve this through different mechanisms.
Fiber Loop Quantum Buffer for Photonic Qubits
Creators: name: Lee, Kim Fook
name: Gul, Gamze
name: Jim, Zhao
name: Kumar, Prem
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report a fiber loop quantum buffer based on a low-loss 2$\times$2 switch and a unit delay made of a fiber delay line. We characterize the device by using a two-photon polarization entangled state in which one photon of the entangled photon pair is stored and retrieved at a repetition rate up to 78$\,\rm{kHz}$. The device, which enables integer multiples of a unit delay, can store the qubit state in a unit of fiber delay line up to 5.4$\,\rm{km}$ and the number of loop round-trips up to 3. Furthermore, we configure the device with other active elements to realize integer multiplies and divider of a unit delay of a qubit. The quantum state tomography is performed on the retrieved photon and its entangled photon. We obtain a state fidelity $>94\%$ with a maximum storage time of 52$\,μ\rm{sec}$. To further characterize the storing and retrieving processes of the device, we perform entanglement-assisted quantum process tomography on the buffered qubit state. The process fidelity of the device is $>$ 0.98. Our result implies that the device preserves the superposition and entanglement of a qubit state from a two-photon polarization-entangled state. This is a significant step towards facilitating applications in optical asynchronous transfer mode (ATM) based quantum networks.
description: 12 pages, 5 figures
title: Patología Ginecológica en urgencias.
Creators: name: Moreu Gamazo, Manuel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Genital / Reproductive system female
subject: Emergency

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Resumir las principales patologías ginecológicas a las que un residente se puede llegar a enfrentar en el servicio de urgencias. Conocer los principales hallazgos de estas patologías: Folículo hemorrágico Torsión ovárica Embarazo ectópico...
Supplementary document for All optical neural network with nonlinear activation functions - 4082710.pdf
Creators: name: Du, Shengwang
name: Zuo, Ying
name: Li, Bohan
name: Zhao, Yujun
name: JIANG, Yue
name: Chen, YOU-CHIUAN
name: Chen, Peng
name: Jo, Gyu-Boong
name: Liu, Junwei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Nonlinear Optics and Spectroscopy

description: Supplemental document
National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
Creators: name: Hauser, A.
name: Hofmann, A.
name: Hanke, K.
name: Bremer, V.
name: Bartmeyer, B.
name: Kuecherer, C.
name: Bannert, N.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p
title: Imagen de la función y disfunción tibial posterior: un enfoque multimodal
Creators: name: Berrocal Morales, Lara
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal soft tissue
subject: Musculoskeletal bone
subject: Anatomy
subject: MR
subject: Ultrasound
subject: Education

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar el espectro de la disfunción tibial posterior (DTP),
centrándonos en el principal estabilizador del arco plantar,
el tendón tibial posterior (TTP),
y su asociación con otras estructuras anatómicas,
como el ligamento calcáneo-navicular...
Fitness and Aortic Stiffness: Modifiable Predictors of Cognitive Ageing
Creators: name: Kennedy, Gregory Ian
Publisher: name: Swinburne
Year: 2024

description: Older age is accompanied by progressive decline in memory and thinking, often culminating in cognitive impairment and dementias such as Alzheimer's disease. With no pharmacological interventions available, research has shifted towards identifying and understanding potentially modifiable risk factors.
This thesis revealed that both physical fitness and stiffness of the aorta are important interventional targets for slowing cognitive decline in older people. However, it was also found that a `one size fits all' approach to intervention strategies may not necessarily be ideal.
These findings contribute towards international efforts to reduce the rates of cognitive impairment and dementia in our ever-ageing society.
An adjoint-based approach to computing time-domain sensitivity of multi-port systems described by reduced-order models
Creators: name: Ahmed, Tamer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: The present thrust in the electronics industry towards integrating multiple functions on a single chip while operating at very high frequencies has highlighted the need for efficient Electronic Design Automation (EDA) tools to shorten the design cycle and capture market windows. One of the fundamental tasks performed by modern EDA tools is the sensitivity analysis, which is concerned with computing the derivatives of various circuit performance metrics w.r.t. the circuit designable parameters. However, the increasing complexity of modern circuit design has made simulation and sensitivity analysis a computationally cumbersome task. Furthermore, the presence of non-linearity in virtually all designs in the form of buffers, driving circuitry, and analog blocks necessitates that these tasks be carried out in the time domain. This thesis describes a new algorithm to compute the time-domain sensitivity using the concept of Model-Order Reduction (MOR). The proposed algorithm enables an interconnected set of large linear systems, that have been abstracted by reduced-order models for the purpose of simulation, to have their sensitivity evaluated in the time domain. Therefore, the key advantage of the proposed work stems from the fact that it brings the computational efficiency of MOR in areas of simulation to bear on the problem of sensitivity analysis. The large systems are assumed to be interconnected within a larger network using lumped linear or nonlinear components, and the desired sensitivity is to be evaluated w.r.t. their internal designable parameters. The proposed algorithm can thus be applied in computing the sensitivity of circuits constructed from microwave devices, such as multi-conductor transmission lines, which when discretized produce large linear systems. The proposed technique also employs the concept of adjoint networks in the sensitivity computation. In addition it can also be used to obtain the sensitivity information in the frequency domain.
Structure and transcriptional regulation of the major intrinsic protein gene family in grapevine
Creators: name: Wong, Darren C. J.
name: Zhang, Li
name: Merlin, Isabelle
name: Castellarin, Simone D.
name: Gambetta, Gregory A.
Publisher: name: BioMed Central
Year: 2018

description: Background: The major intrinsic protein (MIP) family is a family of proteins, including aquaporins, which facilitate water and small molecule transport across plasma membranes. In plants, MIPs function in a huge variety of processes including water transport, growth, stress response, and fruit development. In this study, we characterize the structure and transcriptional regulation of the MIP family in grapevine, describing the putative genome duplication events leading to the family structure and characterizing the family’s tissue and developmental specific expression patterns across numerous preexisting microarray and RNAseq datasets. Gene co-expression network (GCN) analyses were carried out across these datasets and the promoters of each family member were analyzed for cis-regulatory element structure in order to provide insight into their transcriptional regulation. Results: A total of 29 Vitis vinifera MIP family members (excluding putative pseudogenes) were identified of which all but two were mapped onto Vitis vinifera chromosomes. In this study, segmental duplication events were identified for five plasma membrane intrinsic protein (PIP) and four tonoplast intrinsic protein (TIP) genes, contributing to the expansion of PIPs and TIPs in grapevine. Grapevine MIP family members have distinct tissue and developmental expression patterns and hierarchical clustering revealed two primary groups regardless of the datasets analyzed. Composite microarray and RNA-seq gene co-expression networks (GCNs) highlighted the relationships between MIP genes and functional categories involved in cell wall modification and transport, as well as with other MIPs revealing a strong co-regulation within the family itself. Some duplicated MIP family members have undergone sub-functionalization and exhibit distinct expression patterns and GCNs. Cis-regulatory element (CRE) analyses of the MIP promoters and their associated GCN members revealed enrichment for numerous CREs including AP2/ERFs and NACs. Conclusions: Combining phylogenetic analyses, gene expression profiling, gene co-expression network analyses, and cis-regulatory element enrichment, this study provides a comprehensive overview of the structure and transcriptional regulation of the grapevine MIP family. The study highlights the duplication and sub-functionalization of the family, its strong coordinated expression with genes involved in growth and transport, and the putative classes of TFs responsible for its regulation.
Learning Model Predictive Control with Error Dynamics Regression for Autonomous Racing
Creators: name: Xue, Haoru
name: Zhu, Edward L.
name: Dolan, John M.
name: Borrelli, Francesco
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This work presents a novel Learning Model Predictive Control (LMPC) strategy for autonomous racing at the handling limit that can iteratively explore and learn unknown dynamics in high-speed operational domains. We start from existing LMPC formulations and modify the system dynamics learning method. In particular, our approach uses a nominal, global, nonlinear, physics-based model with a local, linear, data-driven learning of the error dynamics. We conducted experiments in simulation and on 1/10th scale hardware, and deployed the proposed LMPC on a full-scale autonomous race car used in the Indy Autonomous Challenge (IAC) with closed loop experiments at the Putnam Park Road Course in Indiana, USA. The results show that the proposed control policy exhibits improved robustness to parameter tuning and data scarcity. Incremental and safety-aware exploration toward the limit of handling and iterative learning of the vehicle dynamics in high-speed domains is observed both in simulations and experiments.
description: Accepted by ICRA 2024
The Availability of Psychological Services for Aged Care Residents in Australia: A Survey of Facility Staff
Creators: name: Stargatt, Jennifer
name: Bhar, Sunil
name: Davison, Tanya
name: Pachana, Nancy A.
name: Mitchell, Leander
name: Koder, Deborah
name: Hunter, Carol
name: Doyle, Colleen
name: Wells, Yvonne
name: Helmes, Edward
Publisher: name: Swinburne
Year: 2024

description: Objective: rates of depression and anxiety are high among older adults in residential aged care facilities (RACFs). This study examined the extent to which psychological services are made available to facility residents in Australia, and investigated barriers to accessing such services. Method: the sample consisted of 90 senior staff from a random sample of RACFs. Participants completed self-report questionnaires regarding their perspectives on the availability of psychological services and potential barriers to access psychological services. Results: access to psychological services was poor. Psychologists were employed at a rate only one third that of other providers of mental health services. Residents were rarely referred to psychologists or to psychological treatments. The most important barriers to access, as perceived by participants, were the low availability of psychologists specialising in treating older adults, lack of government funding for such access, and limited staff training in detecting depression and anxiety. Conclusion: access to psychologists and psychological services remains poor in Australian residential aged care settings. Such access may be improved by developing a workforce of clinical geropsychologists, improving funding mechanisms for residents to access psychological services, and addressing staff knowledge about depression and anxiety.
Supplementary document for All optical neural network with nonlinear activation functions - 4082710.pdf
Creators: name: Du, Shengwang
name: Zuo, Ying
name: Li, Bohan
name: Zhao, Yujun
name: JIANG, Yue
name: Chen, YOU-CHIUAN
name: Chen, Peng
name: Jo, Gyu-Boong
name: Liu, Junwei
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Nonlinear Optics and Spectroscopy

description: Supplemental document
Instrumente zur Wiederverwendung von Bauteilen und hochwertigen Verwertung von Baustoffen
Creators: name: Dechantsreiter, Ute
name: Horst, Peter
name: Mettke, Angelika
Publisher: name: My University
Year: 2015
Subjects: subject: Baustoffrecycling
subject: Bergbauabfall
subject: Betonabbruch
subject: Kreislaufwirtschaft
subject: Mineralstoffabfall
subject: Baustoffwiederverwendung
subject: Gebäuderückbau
subject: Betonrecycling
subject: Bauabfälle
subject: Recyclingbaustoff
subject: Gebrauchtbaustoff
subject: Abfall | Ressourcen
subject: Waste | Resources

description: Die Herstellung von Baustoffen und Bauteilen ist sehr ressourcenintensiv. Deren Recycling und Wiederverwendung können daher einen Beitrag zur Einsparung von Ressourcen und Energie leisten. Bisher ist die Wiederverwendung durchaus funktionsfähiger Bauteile  jedoch noch nicht etabliert und erst in geringem Umfang umgesetzt. Die vorliegende Studie identifiziert daher geeignete Instrumente, die die Wiederverwendung von Bauteilen und eine hochwertige Verwertung von Baustoffen deutlich verbessern und bewertet diese hinsichtlich ihrer ökologischen, technischen und regulativen Kriterien. Dazu wurden in einer Hemmnisanalyse zunächst die Rahmenbedingungen beschrieben, die einem optimalen Umgang mit bereits verwendeten Bauteilen entgegenstehen. Hierauf aufbauend wurden Lösungsansätze formuliert sowie dafür notwendige Weichenstellungen benannt. Hemmnisse einer Wiederverwendung von gut erhaltenen Bauteilen als Ganzes ergeben sich aus Informationsdefiziten zu den Einsatzmöglichkeiten und dem Aufkommen gebrauchter Bauteile und Imageproblemen von Sekundärprodukten. Zudem sind die eindeutigen wirtschaftlichen und ökologischen Vorteile eines Produktrecyclings im Vergleich zum Materialrecycling nicht geklärt. Oftmals mangelt es an verfügbaren Kenndaten zu Betonbauteilen, Haftungs- und Gewährleistungsfragen sind nicht geklärt und es besteht bislang keine Regelung zum Wiedereinsatz von Bauteilen als Bauprodukte. Für Händler fehlen wirtschaftliche Vorteile durch hohe Abbruch- und Aufbereitungsaufwendungen. Um die Wiederverwendung von Bauteilen verbessern zu können, müssten daher Verwertungsstrukturen auf Bundesebene hergestellt werden. Dazu sind weiterführende Informationen für die beteiligten Akteure einschließlich von Hinweisen auf bestehende Annahme- und Verkaufsstellen in kommunalen Medien und die Erarbeitung von Regularien zur Haftung und Gewährleistung von gebrauchten Bauteilen notwendig. Ein einheitliches Prüfsiegel für entsprechende Produkte könnte hierzu ein nützliches Instrument sein.
Towards the use of mixed methods inquiry as best practice in health outcomes research
Creators: name: Regnault, Antoine
name: Willgoss, Tom
name: Barbic, Skye
Publisher: name: Springer International Publishing
Year: 2018

description: Mixed methods research (MMR) has found an increased interest in the field of health outcomes research. Consideration for both qualitative and quantitative perspectives has become key to contextualising patient experiences in a clinically meaningful measurement framework. The purpose of this paper is to outline a process for incorporating MMR in health outcomes research to guide stakeholders in their understanding of the essence of mixed methods inquiry. In addition, this paper will outline the benefits and challenges of MMR and describe the types of support needed for designing and conducting robust MMR measurement studies. MMR involves the application of a well-defined and pre-specified research design that articulates purposely and prospectively, qualitative and quantitative components to generate an integrated set of evidence addressing a single research question. Various methodological design options are possible depending on the research question. MMR designs allow a research question to be studied thoroughly from different perspectives. When applied, it allows the strengths of one approach to complement the restrictions of another. Among other applications, MMR can be used to enhance the creation of conceptual models and development of new instruments, to interpret the meaningfulness of outcomes in a clinical study from the patient perspective, and inform health care policy. Robust MMR requires research teams with experience in both qualitative and quantitative research. Moreover, a thorough understanding of the underlying principles of MMR is recommended at the point of study conception all the way through to implementation and knowledge dissemination. The framework outlined in this paper is designed to encourage health outcomes researchers to apply MMR to their research and to facilitate innovative, patient-centred methodological solutions to address the complex challenges of the field.
Requirements for the façade sound insulation for different types of outdoor noise
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019

description: Buildings are exposed to a wide variety of external noise situations. The time course of the sound pressure level and the frequency response of external noise can vary greatly between the vicinity of roads compared to the vicinity of airports or railways. The sound insulation of facades protect the indoor space s and the residents against external noise day and night. The German standard DIN 4109 "Sound insulation in building constructionâ€Ì contains the minimum requirements for sound insulation for all new buildings in Germany. All requirements are b ased on a single number value, the equivalent sound pressure level, without adequate respecting to the particularities of the frequency response and time structure of a sound source. The presentation shows the German standard values in building acoustics and the subject of external noise. The results of measurements of different sound sources will be shown. A new approach and an outlook for further possibilities to protect inhabitants appropriately to the noise situation will be discussed. Quelle: http://pub.dega-akustik.de
The standard polynomial as an identity on symplectic matrices.
Creators: name: Adamsson, Jay M. H.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Mathematics.

description: The symplectic involution s is defined on $2n \times 2n$ matrices by $$\pmatrix{A&B\cr C&D\cr}\sp{s} = \pmatrix{D\sp{t}&-B\sp{t}\cr -C\sp{t}&A\sp{t}\cr}$$ where A, B, C, and D are $n\times n$ matrices, and t is the standard transpose operation. This thesis investigates the value of the standard polynomial $S\sb{k} := \sum\sb{\sigma\in{\cal S}\sb{k}} (-1)\sp{\sigma} x\sb{\sigma(1)}\cdots x\sb{\sigma(k)}$ evaluated over the ring of matrices which are symmetric with respect to the symplectic involution, denoted $H\sb{n}(F, s).$ In this thesis the value of $S\sb{4n-3}$ for $n \ge 3$ is studied. In particular, it is shown that $S\sb{4n-3}$ is not an identity for n = 3 and n = 4. Moreover, a reduction is obtained in the general case. We choose a particular basis where each basis element can be represented on a graph of 2n points by a pair of labelled, directed edges. A pseudo-Eulerian path on this graph is defined as a path in which exactly one edge of each pair of edges is traversed exactly once. By counting the number of pseudo-Eulerian paths and assigning a value of $-$1 or +1 to each, the value of $S\sb{k}$ can be determined. (Abstract shortened by UMI.)
Iterative Learning Based Controller for Motion Error Correction of an industrial Robot
Creators: name: Stanceski, Sasha
Publisher: name: Swinburne
Year: 2024

description: This research project engaged in, dimensioning the effect of robot user programming, on the positional accuracy, delivered by an industrial robot. User programming was shown to effect the robot positional accuracy, by up to 0.4mm. The positional error was shown to vary within the robot work envelope. Introducing a correction would therefore need to be pose dependent. In a production setting, dimensioning the value of the correction for each pose within the workspace, is time consuming and becomes impractical. Therefore three novel algorithm's were created and used to learn the value of the correction variable, required for any given pose. The benefit of applying the algorithm's, includes, a standardized and automated approach, able to significantly reduce the effect of user programming on the robot positional accuracy.
A discrete chemo-dynamical model of the giant elliptical galaxy NGC 5846: dark matter fraction, internal rotation, and velocity anisotropy out to six effective radii
Creators: name: Zhu, Ling
name: Romanowsky, Aaron J.
name: van de Ven, Glenn
name: Long, R. J.
name: Watkins, Laura L.
name: Pota, Vincenzo
name: Napolitano, Nicola R.
name: Forbes, Duncan
name: Brodie, Jean
name: Foster, Caroline
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We construct a suite of discrete chemo-dynamical models of the giant elliptical galaxy NGC 5846. These models are a powerful tool to constrain both the mass distribution and internal dynamics of multiple tracer populations. We use Jeans models to simultaneously fit stellar kinematics within the effective radius Re, planetary nebula (PN) radial velocities out to 3 Re, and globular cluster (GC) radial velocities and colours out to 6 Re. The best-fitting model is a cored dark matter halo which contributes ~10 per cent of the total mass within 1 Re, and 67 per cent ± 10 per cent within 6 Re, although a cusped dark matter halo is also acceptable. The red GCs exhibit mild rotation with vmax/σ0 ~ 0.3 in the region R > Re, aligned with but counter-rotating to the stars in the inner parts, while the blue GCs and PNe kinematics are consistent with no rotation. The red GCs are tangentially anisotropic, the blue GCs are mildly radially anisotropic, and the PNe vary from radially to tangentially anisotropic from the inner to the outer region. This is confirmed by general made-to-measure models. The tangential anisotropy of the red GCs in the inner regions could stem from the preferential destruction of red GCs on more radial orbits, while their outer tangential anisotropy - similar to the PNe in this region - has no good explanation. The mild radial anisotropy of the blue GCs is consistent with an accretion scenario.
Regenerative tourism within the context of climate disasters
Creators: name: Heschuk, Gabrielle
Publisher: name: University of British Columbia
Year: 2025

description: The financial importance of the tourism industry in BC is well known and continues to be supported by a number of tourism growth strategies at local and provincial levels that are aimed to increase economic profit further. However, in the pursuit of ever increasing economic gain, many believe the tourism industry also actively degrades the natural environment on which it is reliant, simultaneously increasing its vulnerability. Additionally, climate disasters are continuing to increase in prevalence, disrupting tourism industries and the destinations that they support. The objective of this research is to consider the relationship between continued tourism growth and the environment within the context of climate disasters. The approach considers resiliency and regenerative tourism models as a basis for sustainable community development in the City of Kelowna in British Columbia, Canada. This project uncovers destination-specific recovery, resiliency, sustainability and regenerative strategies. This project applied a community-engaged research approach within a case study context in order to collect data that was grounded in the community’s experience. The research was completed in partnership with Tourism Kelowna, a not-for-profit tourism organization based in Kelowna, BC. This project worked directly on their 2022-2025 Destination Development Plan focusing on the second goal to foster the sustainable growth of the destination (Tourism Kelowna, n.d). Using this goal a collaborative research design was used to guide the research project which applies a qualitative, multi-method case study approach of Kelowna, BC using semi-structured interviews that follow a community-engaged research model. Industry and community key-informants were interviewed, to uncover destination specific recovery, resiliency, sustainability and regenerative strategies. These strategies were organized, translated and modified to fit into an accessible and tangible emergency management toolkit for Tourism Kelowna to provide their stakeholders. There are four main findings. Firstly, understanding the factors that increase a destination’s vulnerability is essential in enhancing and implementing resiliency strategies. Secondly, leveraging tourism’s role in a community-based setting is vital to create sustainable and regenerative tourism strategies. Thirdly, there is a critical role that social capital has on building a resilient community. Lastly, tourism plays an important and vital role in emergency management.
Dark-ages reionization and galaxy-formation simulation - VI. The origins and fate of the highest known redshift galaxy
Creators: name: Mutch, Simon J.
name: Liu, Chuanwu
name: Poole, Gregory B.
name: Geil, Paul M.
name: Duffy, Alan
name: Trenti, Michele
name: Oesch, Pascal A.
name: Illingworth, Garth D.
name: Mesinger, Andrei
name: Wyithe, J. Stuart B.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: Using Hubble data, including new grism spectra, Oesch et al. (2016) recently identified GN-z11, a MUV=-21.1 galaxy at z=11.1 (just 400 Myr after the Big Bang). With an estimated stellar mass of ∼109M⊙, this galaxy is surprisingly bright and massive, raising questions as to how such an extreme object could form so early in the Universe. Using Meraxes, a semi-analytic galaxy formation model developed as part of the Dark-ages Reionization And Galaxy-formation Observables from Numerical Simulations (DRAGONS) programme, we investigate the potential formation mechanisms and eventual fate of GN-z11. The volume of our simulation is comparable to that of the discovery observations and possesses two analogue galaxies of similar luminosity to this remarkably bright system. Existing in the two most massive subhaloes at z=11.1 (Mvir=1.4×1011M⊙ and 6.7×1010M⊙), our model analogues show excellent agreement with all available observationally derived properties of GN-z11. Although they are relatively rare outliers from the full galaxy population at high-z, they are no longer the most massive or brightest systems by z=5. Furthermore, we find that both objects possess relatively smooth, but extremely rapid mass growth histories with consistently high star formation rates and UV luminosities at z>11, indicating that their brightness is not a transient, merger driven feature. Our model results suggest that future wide-field surveys with JWST may be able to detect the progenitors of GN-z11 analogues out to z∼13-14, pushing the frontiers of galaxy-formation observations to the early phases of cosmic reionization and providing a valuable glimpse of the first galaxies to reionize the Universe on large scales.
Nilotinib Is More Potent than Imatinib for Treating Plexiform Neurofibroma In Vitro and In Vivo
Creators: name: Wei, Jiang
name: Freytag, Marcus
name: Schober, Yvonne
name: Nockher, Wolfgang A.
name: Mautner, Victor F.
name: Friedrich, Reinhard E.
name: Manley, Paul W.
name: Kluwe, Lan
name: Kurtz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Plexiform neurofibromas (PNFs) are benign nerve sheath tumors mostly associated with neurofibromatosis type 1. They often extend through multiple layers of tissue and therefore cannot be treated satisfactorily by surgery. Nilotinib is a tyrosine kinase inhibitor used to treat leukemia, with advantages over the prototype imatinib in terms of potency and selectivity towards BCR-ABL, and the DDR, PDGFR, and KIT receptor kinases. In this study, we compared efficacies of the two drugs on cultured cells of PNF in vitro and on xenografted tumor fragments on sciatic nerve of athymic nude mice. Xenografts were monitored weekly using a high resolution ultrasound measurement. Treatment with nilotinib at a daily dose of 100 mg/kg for four weeks led to a reduction of the graft sizesstd by 68±7% in the 8 treated mice, significantly more than the 33±8% reduction in the 8 untreated mice (P<0.05) and the 47±15% in the 7 mice treated with imatinib (P<0.05). The peak plasma nilotinib concentration 6.6±1.1 µM is within the pharmacological range of clinical application. Imatinib, but not nilotinib significantly hindered body weight increase of the mice and elevated cytotoxicity of mouse spleen cells (P<0.05). Our results suggest that nilotinib may be more potent than imatinib for treating PNFs and may also be better tolerated. Imatinib seems to have some off-target effect in elevating immunity.
Ordered groups and crossed products of AF-related C*-algebras
Creators: name: Rada, Catalin Constantin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Mathematics.

description: Let C be the canonical diagonal MASA in an AF algebra A. We show that an automorphism &phis; of C extends to an approximately inner automorphism alpha of A iff p is Murray-von Neumann equivalent in A to &phis;( p) for every projection p ∈ C. We determine some classes of AF algebras for which the ordered K 0-groups of the two crossed products, arising from these dynamical systems, are isomorphic and we show that the entropies of &phis; and alpha are equal. Along the way, we obtain results about when K0( A ⋉aZ ) (equipped with natural order) is pre-order isomorphic with K0(A)/Im(id-- K0(alpha)) (equipped with the quotient order) for a large class of automorphisms alpha of the AF algebra A. I. Putnam has proved that C(X) ⋉fZ is a (simple) AT algebra when X is the Cantor set and &phis; is a minimal self-homeomorphism of X. We extend his results to non-commutative AF algebras that have the set of extremal tracial states homeomorphic with the Cantor set, and satisfy a certain lifting property. The proof is based (as in the commutative case) on constructions of intermediate AF subalgebras (associated to closed subsets of deltaeT (A)) of the crossed product and on the lifting. We study the structure of the crossed products by Z of algebras of type C(X) ⊗ B, where X is the Cantor set, B is a unital, simple, topological tracial rank zero or one C*-algebra and the automorphism is alphaT ⊗ beta, where T is a minimal homeomorphism of X and beta ∈ Aut0. Using the work of Matui and Lin we show that the crossed product algebra has still topological tracial rank zero or one. The last topic addressed in this thesis concerns the natural map: Asa → AffT(A), where T(A) is the simplex of tracial states of a unital C*-algebra A. Considering the natural orders on Asa and on AffT(A ), we found examples of C*-algebras for which the natural maps lifts positive functions to positive elements in A.
RCSLenS: The Red Cluster Sequence Lensing Survey
Creators: name: Hildebrandt, H.
name: Choi, A.
name: Heymans, C.
name: Blake, Chris
name: Erben, T.
name: Miller, L.
name: Nakajima, R.
name: van Waerbeke, L.
name: Viola, M.
name: Buddendiek, A.
name: Harnois-Déraps, J.
name: Hojjati, A.
name: Joachimi, B.
name: Joudaki, Shahab
name: Kitching, T. D.
name: Wolf, C.
name: Gwyn, S.
name: Johnson, N.
name: Kuijken, K.
name: Sheikhbahaee, Z.
name: Tudorica, A.
name: Yee, H. K. C.
Publisher: name: Swinburne
Year: 2024

description: We present the Red Cluster Sequence Lensing Survey (RCSLenS), an application of the methods developed for the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS) to the similar to 785 deg(2), multi-band imaging data of the Red-sequence Cluster Survey 2. This project represents the largest public, sub-arcsecond seeing, multi-band survey to date that is suited for weak gravitational lensing measurements. With a careful assessment of systematic errors in shape measurements and photometric redshifts, we extend the use of this data set to allow cross-correlation analyses between weak lensing observables and other data sets. We describe the imaging data, the data reduction, masking, multi-colour photometry, photometric redshifts, shape measurements, tests for systematic errors, and a blinding scheme to allow for more objective measurements. In total, we analyse 761 pointings with r-band coverage, which constitutes our lensing sample. Residual large-scale B-mode systematics prevent the use of this shear catalogue for cosmic shear science. The effective number density of lensing sources over an unmasked area of 571.7 deg(2) and down to a magnitude limit of r similar to 24.5 is 8.1 galaxies per arcmin(2) (weighted: 5.5 arcmin(-2)) distributed over 14 patches on the sky. Photometric redshifts based on four-band griz data are available for 513 pointings covering an unmasked area of 383.5 deg(2). We present weak lensing mass reconstructions of some example clusters as well as the full survey representing the largest areas that have been mapped in this way. All our data products are publicly available through Canadian Astronomy Data Centre at http://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/en/community/rcslens/query.html in a format very similar to the CFHTLenS data release.
Preparing pure $^{43}$Ca$^+$ samples in an ion trap with photoionization and parametric excitations
Creators: name: Kuo, C. -H.
name: Hsiao, Y. -C.
name: Jhang, C. -Y.
name: Chen, Y. -D.
name: Tung, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a practical scheme for the efficient preparation of laser-cooled $^{43}$Ca$^+$ ions in an ion trap. Our approach integrates two well-established methods: isotope-selective photoionization and isotope-specific parametric excitation. Drawing inspiration from the individual merits of each method, we have successfully integrated these techniques to prepare extended chains of $^{43}$Ca$^+$ ions, overcoming the challenge posed by their low natural abundance of 0.135\% in a natural source. Furthermore, we explore the subtleties of our scheme, focusing on the influence of different factors on the purification process. Our investigation contributes to a broader understanding of the technique and highlights the adaptability of established methods in addressing specific isotopic challenges.
description: 10 pages with 6 figures
Developing a Relationship between Subjective and Objective Pavement Condition Data
Creators: name: Tasmin, Tamina
Publisher: name: Swinburne
Year: 2024

description: Several subjective pavement surface condition rating systems are used by highway departments as an expedient tool to determine the potential need for periodic resurfacing maintenance work. This visual rating is prone to be biased, causes traffic disruptions, and is risky for the assessors required to carry it out. Therefore, in the current study, a set of relationships are developed to relate subjective ratings to objective/directly measured pavement condition data, in the hope that the need for visual pavement surface rating in triggering resurfacing program, at the network level, may be reduced or removed.
Genome rearrangement algorithms applied to comparative maps
Creators: name: Zheng, Chunfang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Bioinformatics.

description: The Hannenhalli-Pevzner algorithm for computing the evolutionary distance between two genomes is very efficient when the genomes are signed and totally ordered. But in real comparative maps, the data suffer from problems such as coarseness, missing data, no signs, paralogy, order conflicts and mapping noise. In this thesis we have developed a suite of algorithms for genome rearrangement analysis in the presence of noise and incomplete information. For coarseness and missing data, we represent each chromosome as a partial order, summarized by a directed acyclic graph (DAG). We augment each DAG to a directed graph (DG) in which all possible linearizations are embedded. The chromosomal DGs representing two genomes are combined to produce a single bicoloured graph. The major contribution of the thesis is an algorithm for extracting a maximal decomposition of some subgraph into alternating coloured cycles, determining an optimal sequence of rearrangements, and hence the genomic distance. Also based on this framework, we have proposed an algorithm to solve all the above problems of comparative maps simultaneously by adding heuristic preprocessing to the exact algorithm approach. We have applied this to the comparison of maize and sorghum genomic maps on the GRAMENE database. A further contribution treats the inflation of genome distance by high levels of noise due to incorrectly resolved paralogy and error at the mapping, sequencing and alignment levels. We have developed an algorithm to remove the noise by maximizing strips and tested its robustness as noise levels increase.
Constraints on the broad-line region properties and extinction in local Seyferts
Creators: name: Schnorr-Müller, Allan
name: Davies, Rebecca
name: Korista, K. T.
name: Burtscher, L.
name: Rosario, D.
name: Storchi-Bergmann, T.
name: Contursi, A.
name: Genzel, R.
name: Graciá-Carpio, J.
name: Hicks, E. K. S.
name: Janssen, A.
name: Koss, M.
name: Lin, M. -Y.
name: Lutz, D.
name: Maciejewski, W.
name: Müller-Sánchez, F.
name: Orban de Xivry, G.
name: Riffel, R.
name: Riffel, Rogemar A.
name: Schartmann, Marc
name: Sternberg, A.
name: Sturm, E.
name: Tacconi, L.
name: Veilleux, S.
name: Ulrich, O. A.
Publisher: name: Swinburne
Year: 2024

description: We use high-spectral resolution (R > 8000) data covering 3800-13 000 Å to study the physical conditions of the broad-line region (BLR) of nine nearby Seyfert 1 galaxies. Up to six broad H i lines are present in each spectrum. A comparison - for the first time using simultaneous optical to near-infrared observations - to photoionization calculations with our devised simple scheme yields the extinction to the BLR at the same time as determining the density and photon flux, and hence distance from the nucleus, of the emitting gas. This points to a typical density for the H i emitting gas of 1011 cm-3 and shows that a significant amount of this gas lies at regions near the dust sublimation radius, consistent with theoretical predictions. We also confirm that in many objects, the line ratios are far from case B, the best-fitting intrinsic broad-line Hα/H β ratios being in the range 2.5-6.6 as derived with our photoionization modelling scheme. The extinction to the BLR, based on independent estimates from H i and He ii lines, is AV ≤ 3 for Seyfert 1-1.5s, while Seyfert 1.8-1.9s have AV in the range 4-8. A comparison of the extinction towards the BLR and narrow-line region (NLR) indicates that the structure obscuring the BLR exists on scales smaller than the NLR. This could be the dusty torus, but dusty nuclear spirals or filaments could also be responsible. The ratios between the X-ray absorbing column NH and the extinction to the BLR are consistent with the Galactic gas-to-dust ratio if NH variations are considered.
Ballet teachers: A source of perceived weight loss pressure in female ballet students.
Creators: name: Bottamini, Gina L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Dance.

description: The main purpose of this study was to examine the role of the ballet teacher as a perceived source of weight loss pressure for the ballet student. Another purpose was to examine whether there could be a positive relationship between the reported use of unhealthy methods of losing weight and the perception of the teacher as a source of weight loss pressure. Finally, we sought to identify the forms of communication used by the teachers that could be construed as weight loss pressures by the students. Forty ballet students participated in the study and completed the BALLET Scale, Eating Behaviors Scale and the Athletic Image Scale. Students were placed into one of two groups based on their answers to the Athletic Image Scale (combined-pressures, no-pressures). The results showed that students did perceive the teacher as a source of weight loss pressure. Further, a positive relationship existed between students who perceived the teacher as a source of weight loss pressure and unhealthy eating behaviors. The results also showed that students in the combined-pressures group perceived more forms of communication by the teacher as weight loss pressures.
RCSLenS: A new estimator for large-scale galaxy-matter correlations
Creators: name: Buddendiek, A.
name: Schneider, P.
name: Hildebrandt, H.
name: Blake, Chris
name: Choi, A.
name: Erben, T.
name: Heymans, C.
name: van Waerbeke, L.
name: Viola, M.
name: Harnois-Deraps, J.
name: Koens, L.
name: Nakajima, R.
Publisher: name: Swinburne
Year: 2024

description: We present measurements of the galaxy bias b and the galaxy-matter cross-correlation coefficient r for the Baryon Oscillation Spectroscopic Survey LOWZ luminous red galaxy sample. Using a new statistical weak lensing analysis of the Red Cluster Sequence Lensing Survey (RCSLenS), we find the bias properties of this sample to be higher than previously reported with b=2.45_{-0.05}^{+0.05} and r=1.64_{-0.16}^{+0.17} on scales between 3 and 20 arcmin. We repeat the measurement for angular scales of 20 arcmin ≤ ϑ ≤ 70 arcmin, which yields b=2.39_{-0.07}^{+0.07} and r=1.24_{-0.25}^{+0.26}. This is the first application of a data compression analysis using a complete set of discrete estimators for galaxy-galaxy lensing and galaxy clustering. As cosmological data sets grow, our new method of data compression will become increasingly important in order to interpret joint weak lensing and galaxy clustering measurements and to estimate the data covariance. In future studies, this formalism can be used as a tool to study the large-scale structure of the Universe to yield a precise determination of cosmological parameters.