cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optical properties, of waters in the Murray-Darling Basin, South-eastern Australia
Creators: name: Oliver, R. L
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Apparent and inherent optical properties were determined for a range of water types in the Murray- Darling basin by using a combination of field and laboratory techniques. The absorption coefficient was calculated directly from in situ irradiance measurements of photosynthetically active radiation, whereas the scattering coefficient was determined from the irradiance measurements in conjunction with published nomograms relating the apparent and inherent optical properties. The validity of the nomograms for use in these waters was confirmed by comparing values of the average cosine calculated directly from in situ measurements with those estimated from the nomograms. These were closely correlated except for sites with chlorophyll concentrations greater than 200 mg m-3. The scattering coefficients estimated from the nomograms were approximately numerically equal to the turbidity in nephelometric turbidity units, but the variability of the relationship made it unsuitable for checking the validity of the nomograms. The relative role of dissolved and particulate components in the absorption and scattering of irradiance was examined by using spectrophotometry and linear regression of inherent optical properties on concentrations of the components. Estimates of specific absorption and scattering coefficients for algae, non-chlorophyllous suspended particles, and dissolved yellow colour were comparable to similar coefficients reported in the literature. The relative importance of these components to absorption and scattering varied considerably between sites and demonstrated the need for information on inherent optical properties in understanding the factors causing changes in optical water quality.
The Planck clusters in the LOFAR sky: IV: LoTSS-DR2: statistics of radio halos and re-acceleration models
Creators: name: Cassano, R.
name: Cuciti, V.
name: Brunetti, G.
name: Botteon, A.
name: Rossetti, M.
name: Bruno, L.
name: Simionescu, A.
name: Gastaldello, F.
name: van Weeren, R. J.
name: Brueggen, M.
name: Dallacasa, D.
name: Zhang, X.
name: Akamatsu, H.
name: Bonafede, A.
name: Di Gennaro, G.
name: Shimwell, T. W.
name: de Gasperin, F.
name: Roettgering, H. J. A.
name: Jones, A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Diffuse cluster-scale synchrotron radio emission is discovered in an increasing number of galaxy clusters in the form of radio halos (RHs), probing the presence of relativistic electrons and magnetic fields in the intra-cluster medium. The favoured scenario to explain their origin is that they trace turbulent regions generated during cluster mergers where particles are re-accelerated. In this framework, RHs are expected to probe cluster dynamics and are predicted to be more frequent in massive systems. Statistical studies are important to study the connection of RHs with cluster dynamics and to constrain theoretical models. Furthermore, low-frequency surveys can shed light on the existence of RHs with very steep radio-spectra, a key prediction of turbulent models. We study the properties of RHs from clusters of the second catalog of Planck Sunyaev Zel'dovich detected sources that lie within the 5634 deg^2 covered by the second Data Release (DR2) of the LOFAR Two-meter Sky Survey. We find that the number of observed RHs, their radio flux density and redshift distributions are in line with what is expected in the framework of the re-acceleration scenario. In addition, the fraction of clusters with RHs increases with the cluster mass, confirming the leading role of the gravitational process of cluster formation in the generation of RHs. These models predict a large fraction of RHs with very steep spectrum in the DR2 Planck sample, this will be tested in future studies, yet a comparison of the occurrence of halos in GMRT and LOFAR samples indeed shows a larger occurrence of RHs at lower frequencies suggesting the presence of a number of very steep spectrum RH that is preferentially detected by LOFAR. Using morphological information we confirm that RHs are preferentially located in merging systems and that the fraction of newly LOFAR discovered RHs is larger in less disturbed systems.
description: 12 pages, 10 figures, accepted for publication in A&A
Inverse-kinematics proton scattering on $^{50}$Ca: Determining effective charges using complementary probes
Creators: name: Riley, L. A.
name: Agiorgousis, M. L.
name: Baugher, T. R.
name: Bazin, D.
name: Bowry, M.
name: Cottle, P. D.
name: DeVone, F. G.
name: Gade, A.
name: Glowacki, M. T.
name: Kemper, K. W.
name: Lunderberg, E.
name: McPherson, D. M.
name: Noji, S.
name: Recchia, F.
name: Sadler, B. V.
name: Scott, M.
name: Weisshaar, D.
name: Zegers, R. G. T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We have performed measurements of the $0_\mathrm{g.s.}^+ \rightarrow 2_1^+$ excitations in the neutron-rich isotopes $^{48,50}$Ca via inelastic proton scattering on a liquid hydrogen target, using the GRETINA $γ$-ray tracking array. A comparison of the present results with those from previous measurements of the lifetimes of the $2_1^+$ states provides us the ratio of the neutron and proton matrix elements for the $0_\mathrm{g.s.}^+ \rightarrow 2_1^+$ transitions. These results allow the determination of the ratio of the proton and neutron effective charges to be used in shell model calculations of neutron-rich isotopes in the vicinity of $^{48}$Ca.
description: Phys. Rev. C, accepted
New York Times Upshot/Siena College: September 2020 Nebraska Poll Wave 1
Creators: name: New York Times
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: Likelihood of voting (1); 2020 presidential election (5); vote for or against candidates (7); republican presidential candidate Donald Trump (6); democratic presidential candidate Joe Biden (6); libertarian candidate Jo Jorgenson (3); Green Party candidate Howie Hawkins (3); 2020 House election (2); democratic candidate Kara Eastman (2); republican candidate Don Bacon (2); libertarian candidate Tyler Schaeffer (2); President Donald Trump job approval (1); favorability of politicians or political movements (2); voted in previous elections (2).
Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities
Creators: name: Unsal-Kacmaz, K.
name: Sancar, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: ATR is an essential protein that functions as a damage sensor and a proximal kinase in the DNA damage checkpoint response in mammalian cells. It is a member of the phosphoinositide 3-kinase-like kinase (PIKK) family, which includes ATM, ATR, and DNA-dependent protein kinase. Recently, it was found that ATM is an oligomeric protein that is converted to an active monomeric form by phosphorylation in trans upon DNA damage, and this raised the possibility that other members of the PIKK family may be regulated in a similar manner. Here we show that ATR is a monomeric protein associated with a smaller protein called ATRIP with moderate affinity. The ATR protein by itself or in the form of the ATR-ATRIP heterodimer binds to naked or replication protein A (RPA)-covered DNAs with comparable affinities. However, the phosphorylation of RPA by ATR is dependent on single-stranded DNA and is stimulated by ATRIP. These findings suggest that the regulation and mechanism of action of ATR are fundamentally different from those of the other PIKK proteins.
Suppressor of sable, a Putative RNA-Processing Protein, Functions at the Level of Transcription
Creators: name: Brewer-Jensen, P.
name: Searles, L. L.
name: Kuan, Y.-S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The Drosophila melanogaster su(s) gene product negatively regulates the expression of mutant alleles with transposon insertions in the 5′-transcribed region by an unknown mechanism. We have investigated here su(s) function through in vivo structure-function analysis, heterologous reporter gene assays, and in vivo transcriptional induction experiments. We have shown that mutations of two arginine-rich motifs (ARMs), an acidic region, or two CCCH zinc fingers affect the ability of Su(s) to downregulate the expression of an insertion mutant allele and to autoregulate genomic su(s) transgenes. Using yeast and HeLa cell assays, we found that, when tethered to the promoter region, the N- and C-terminal regions of Su(s) can repress reporter gene expression, and all three motifs, but most significantly the ARMs, contribute to the repression activity. Finally, we showed that, in vivo, Su(s) inhibits the transcriptional induction of a transgene with an insertion in the first exon but does not affect induction of a similar transgene with a consensus 5′ splice site near the upstream boundary of the insertion. Together, these results reveal a link between Su(s), transcription, and pre-mRNA processing.
Prheri: A Foundational Logging Framework for Containerized Environments
Creators: name: Sharma, Saksham
name: Kihore, Brian
name: Shandil, Sparsh
Publisher: name: Zenodo
Year: 2025

description: Prheri is an open-source logging framework designed to provide comprehensive visibility into containerized environments, such as Kubernetes and Docker. It collects, processes, and stores logs from container runtimes, host systems, and orchestration layers, enabling efficient post-incident analysis and operational insights. With features like real-time log aggregation, metadata enrichment, and optimized storage (achieving a 3:1 compression ratio), Prheri ensures high performance and scalability in production-scale clusters.

This release focuses on foundational logging capabilities, capturing 142 distinct log event types with 99.7% data integrity while maintaining minimal resource overhead (3.8% CPU usage per node). The system supports SQL-like queries for advanced log analysis and lays the groundwork for future integrations with runtime security tools like Falco.

Key features include:

Real-time log collection from Docker and Kubernetes environments.

Metadata enrichment for enhanced contextual analysis.

Tiered storage architecture with configurable retention policies.

High throughput (14,000 log entries/second) with low query latency (230ms P95).

Future development plans include runtime anomaly detection, automated threat response workflows, and integration with threat intelligence feeds.
title: Sensitivity of a Gas Filter Correlation Instrument to Variations in Atmospheric Profile and Earth Surface Temperatures
Creators: name: Casas, Joseph C.
Publisher: name: Old Dominion University Libraries
Year: 1975

description: The Gas Filter Correlation Radiometer Analyzer (GFCR), in application to the remote sensing of trace gases in the atmosphere, is potentially limited by the sensitivity of the measured upwelling thermal radiation to surface temperature and atmospheric temperature conditions. This study has been carried out to examine the principles of operation of the GFCR Analyzer and to obtain quantitative estimates of the errors produced in GFCR Analyzer measurements of CO (4.6μ), S02 (8.6μ), NH3 (11.0μ), and CH4 (8.1μ) resulting from uncertainties in the atmospheric temperature profile and ground temperature.

A simple mathematical prototype GFCR Analyzer was assumed. A line-by-line atmospheric radiative transfer calculation was used to simulate the response of the instrument to varying concentrations of trace gases in several model atmospheres. Baseline results were calculated using the U.S. Standard 1962 Atmosphere and were then compared to results obtained using the other realistic models.
The Planck clusters in the LOFAR sky. II. LoTSS-DR2: Recovering diffuse extended emission with LOFAR
Creators: name: Bruno, L.
name: Brunetti, G.
name: Botteon, A.
name: Cuciti, V.
name: Dallacasa, D.
name: Cassano, R.
name: van Weeren, R. J.
name: Shimwell, T.
name: Taffoni, G.
name: Russo, S. A.
name: Bonafede, A.
name: Brüggen, M.
name: Hoang, D. N.
name: Röttgering, H. J. A.
name: Tasse, C.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Extended radio sources in the sky require a dense sampling of short baselines to be properly imaged by interferometers. This problem arises in many areas of radio astronomy, such as in the study of galaxy clusters, which may host Mpc-scale diffuse synchrotron sources in the form of radio halos. In clusters where no radio halos are detected, owing to intrinsic absence of emission or extrinsic (instrumental and/or observational) effects, it is possible to determine upper limits. We consider a sample of Planck galaxy clusters from the Second Data Release of the LOFAR Two Meter Sky Survey (LoTSS-DR2) where no radio halos are detected. We use this sample to test the capabilities of LOFAR to recover diffuse extended emission and derive upper limits. Through the injection technique, we simulate radio halos with various surface brightness profiles. We then predict the corresponding visibilities and image them along with the real visibilities. This method allows us to test the fraction of flux density losses owing to inadequate uv-coverage and obtain thresholds at which the mock emission becomes undetectable by visual inspection. The dense uv-coverage of LOFAR at short spacings allows to recover $\gtrsim90\%$ of the flux density of targets with sizes up to $\sim 15'$. We find a relation that provides upper limits based on the image noise and extent (in terms of number of beams) of the mock halo. This relation can be safely adopted to obtain upper limits without injecting when artifacts introduced by the subtraction of the discrete sources are negligible in the central region of the cluster. Otherwise, the injection process and visual inspection of the images are necessary to determine more reliable limits. Through these methods, we obtain upper limits for 75 clusters to be exploited in ongoing statistical studies.
description: 20 pages (including Appendices). 21 Figures. 4 Tables. Accepted for publication by A&A. For the project Webpage see https://lofar-surveys.org/planck_dr2.html
Your Consent Is Worth 75 Euros A Year -- Measurement and Lawfulness of Cookie Paywalls
Creators: name: Morel, Victor
name: Santos, Cristiana
name: Lintao, Yvonne
name: Human, Soheil
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Most websites offer their content for free, though this gratuity often comes with a counterpart: personal data is collected to finance these websites by resorting, mostly, to tracking and thus targeted advertising. Cookie walls and paywalls, used to retrieve consent, recently generated interest from EU DPAs and seemed to have grown in popularity. However, they have been overlooked by scholars. We present in this paper 1) the results of an exploratory study conducted on 2800 Central European websites to measure the presence and practices of cookie paywalls, and 2) a framing of their lawfulness amidst the variety of legal decisions and guidelines.
Target Gene-Specific Modulation of Myocardin Activity by GATA Transcription Factors
Creators: name: Olson, E. N.
name: Wang, Z.
name: Lien, C.-L.
name: Xing, W.
name: Oh, J.
name: Wang, D.-Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Myocardin is a transcriptional coactivator that regulates cardiac and smooth muscle gene expression by associating with serum response factor. We show that GATA transcription factors can either stimulate or suppress the transcriptional activity of myocardin, depending on the target gene. Modulation of myocardin activity by GATA4 is mediated by the physical interaction of myocardin with the DNA binding domain of GATA4 but does not require binding of GATA4 to DNA. Paradoxically, the transcription activation domain of GATA4 is dispensable for the stimulatory effect of GATA4 on myocardin activity but is required for repression of myocardin activity. The ability of GATA transcription factors to modulate myocardin activity provides a potential mechanism for fine tuning the expression of serum response factor target genes in a gene-specific manner.
Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops
Creators: name: Griffith, J. D.
name: Cesare, A. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: A prerequisite for cellular immortalization in human cells is the elongation of telomeres through the upregulation of telomerase or by the alternative lengthening of telomeres (ALT) pathway. In this study, telomere structure in multiple ALT cell lines was examined by electron microscopy. Nuclei were isolated from GM847, GM847-Tert, and WI-38 VA13 ALT cells, psoralen photo-cross-linked in situ, and the telomere restriction fragments were purified by gel filtration chromatography. Examination of telomere-enriched fractions revealed frequent extrachromosomal circles, ranging from 0.7 to 56.8 kb. t-loops were also observed, with the loop portion ranging from 0.5 to 70.2 kb. The total length of the loop plus tail of the t-loops corresponded to the telomere restriction fragment length from the ALT cell lines as determined by pulsed-field gel electrophoresis. The presence of extrachromosomal circles containing telomeric DNA was confirmed by two-dimensional pulsed-field gel electrophoresis. These results show that extrachromosomal telomeric DNA circles are present in ALT nuclei and suggest a roll-and-spread mechanism of telomere elongation similar to that seen in previous observations of multiple yeast species. Results presented here also indicate that expression of telomerase in GM847 cells does not affect t-loop or extrachromosomal circle formation.
The Oligo(A) Tail on Histone mRNA Plays an Active Role in Translational Silencing of Histone mRNA during Xenopus Oogenesis
Creators: name: Marzluff, W. F.
name: Sanchez, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Metazoan replication-dependent histone mRNAs end in a stem-loop sequence. The one known exception is the histone mRNA in amphibian oocytes, which has a short oligo(A) tail attached to the stem-loop sequence. Amphibian oocytes also contain two proteins that bind the 3′ end of histone mRNA: xSLBP1, the homologue of the mammalian SLBP, and xSLBP2, which is present only in oocytes. xSLBP2 is an inhibitor of histone mRNA translation, while xSLBP1 activates translation. The short A tail on histone mRNAs appears at stage II to III of oogenesis and is present on histone mRNAs throughout the rest of oogenesis. At oocyte maturation, the oligo(A) tail is removed and the xSLBP2 is degraded, resulting in the activation of translation of histone mRNA. Both SLBPs bind to the stem-loop with the oligo(A) tail with similar affinities. Reporter mRNAs ending in the stem-loop with or without the oligo(A) tail are translated equally well in a reticulocyte lysate, and their translation is stimulated by the presence of xSLBP1. In contrast, translation of the reporter mRNA with an oligo(A) tail is not activated in frog oocytes in response to the presence of xSLBP1. These results suggest that the oligo(A) tail is an active part of the translation repression mechanism that silences histone mRNA during oogenesis and that its removal is part of the mechanism that activates translation.
TRAM2 Protein Interacts with Endoplasmic Reticulum Ca2+ Pump Serca2b and Is Necessary for Collagen Type I Synthesis
Creators: name: Schnabl, B.
name: Bataller, R.
name: Stefanovic, L.
name: Stefanovic, B.
name: Brenner, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Cotranslational insertion of type I collagen chains into the lumen of the endoplasmic reticulum (ER) and their subsequent folding into a heterotrimeric helix is a complex process which requires coordinated action of the translation machinery, components of translocons, molecular chaperones, and modifying enzymes. Here we describe a role for the protein TRAM2 in collagen type I expression in hepatic stellate cells (HSCs) and fibroblasts. Activated HSCs are collagen-producing cells in the fibrotic liver. Quiescent HSCs produce trace amounts of type I collagen, while upon activation collagen synthesis increases 50- to 70-fold. Likewise, expression of TRAM2 dramatically increases in activated HSCs. TRAM2 shares 53% amino acid identity with the protein TRAM, which is a component of the translocon. However, TRAM2 has a C terminus with only a 15% identity. The C-terminal part of TRAM2 interacts with the Ca2+ pump of the ER, SERCA2b, as demonstrated in a Saccharomyces cerevisiae two-hybrid screen and by immunoprecipitations in human cells. TRAM2 also coprecipitates with anticollagen antibody, suggesting that these two proteins interact. Deletion of the C-terminal part of TRAM2 inhibits type I collagen synthesis during activation of HSCs. The pharmacological inhibitor of SERCA2b, thapsigargin, has a similar effect. Depletion of ER Ca2+ with thapsigargin results in inhibition of triple helical collagen folding and increased intracellular degradation. We propose that TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding.
title: Analysis of surface displacements caused by mine flooding for the project FloodRisk with SAR Interferometry, GNSS and Levelling
Creators: name: Even ,  Markus
name: Westerhaus ,  Malte
name: Schröder ,  Daniel
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: After operation of hard coal mines has been terminated in Germany, many of the mines are being flooded. In the project “FloodRisk: Earthquakes, uplift, and long-term liabilities – risk minimization during mine flooding”, the consequences of the rising mine water levels are investigated from a multidisciplinary perspective. Geodetic, geophysical, geomechanical and geological approaches are combined to develop a conceptional model for flooding induced surface displacements and seismicity. Saarland, Ruhr area and Ibbenbüren have been chosen as exemplary investigation areas. The DMT GmbH & Co. KG (DMT) and the Geodetic Institute Karlsruhe (GIK) contribute to the project by analyzing surveying and InSAR data. DMT installs ten low-cost GNSS-Sensors near Bergwerk Ost and includes them in DMT SAFEGUARD, a proprietary GNSS monitoring system, that provides an integrated evaluation and provision service. GIK is analyzing InSAR data from Sentinel 1a/b and intends to combine GNSS, levelling and InSAR data from different orbits to derive 3D displacements. Challenges that are typical for mining areas as the spatially as well as temporally diverse displacement patterns demand for new solutions in InSAR processing. The so found displacements of the earth’s surface will be integrated with geomechanical modeling in the final phase of the project. In this presentation, the goals, challenges and approaches of FloodRisk with regard to geodesy are discussed and first results are shown.
The exact probability law for the approximated similarity from the Minhashing method
Creators: name: Dembele, Soumaila
name: Lo, Gane Samb
Publisher: name: arXiv
Year: 2022
Subjects: subject: Probability (math.PR)
subject: Applications (stat.AP)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 62E15, 62F12, 68R05, 68R15, 68Q97

description: We propose a probabilistic setting in which we study the probability law of the Rajaraman and Ullman \textit{RU} algorithm and a modified version of it denoted by \textit{RUM}. These algorithms aim at estimating the similarity index between huge texts in the context of the web. We give a foundation of this method by showing, in the ideal case of carefully chosen probability laws, the exact similarity is the mathematical expectation of the random similarity provided by the algorithm. Some extensions are given. \noindent \textbf{Résumé.} Nous proposons un cadre probabilistique dans lequel nous étudions la loi de probabilité de l'algorithme de Rajaraman et Ullman \textit{RU} ainsi qu'une version modifiée de cet algorithme notée \textit{RUM}. Ces alogrithmes visent à estimer l'indice de la similarité entre des textes de grandes tailles dans le contexte du Web. Nous donnons une base de validité de cette méthode en montrant que pour des lois de probabilités minutieusement choisies, la similarité exacte est l'espérance mathématique de la similarité aléatoire donnée par l'algorithme \textit{RUM}. Des généralisations sont abordées.
Transforming Growth Factor  /Smad3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter
Creators: name: Liu, C.
name: Qing, J.
name: Choy, L.
name: Derynck, R.
name: Wu, R.-Y.
name: Pagano, J. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The rapid induction of alpha interferon (IFN-α) and IFN-β expression plays a critical role in the innate immune response against viral infection. We studied the effects of transforming growth factor β (TGF-β) and its intracellular effectors, the Smads, on the function of IRF-7, an essential transcription factor for IFN-α and -β induction. IRF-7 interacted with Smads, and IRF-7, but not IRF-3, cooperated with Smad3 to activate IFN-β transcription. This transcriptional cooperation occurred at the IRF-binding sequences in the IFN-β promoter, and dominant-negative interference with TGF-β receptor signaling and Smad3 function decreased IRF-7-mediated transcription. Furthermore, elimination of Smad3 expression in Smad3−/− fibroblasts delayed and decreased double-stranded RNA-induced expression of endogenous IFN-β, whereas restoration of Smad3 expression enhanced IFN-β induction. The IRF-7-Smad3 cooperativity resulted from the regulation of the transactivation activity of IRF-7 by Smad3, and dominant-negative interference with Smad3 function decreased IRF-7 activity. Consistent with the regulation by Smad3, the transcriptional activity of IRF-7 depended on and was regulated by TGF-β signaling. Our studies underscore a role of TGF-β/Smad3 signaling in IRF-7-mediated induction of IFN-β expression.
Organic matter degradation and nutrient regeneration in Australian freshwaters: II. Spatial and temporal variation, and relation with environmental conditions
Creators: name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Rates of exoenzyme activity in the water column of 17 sites in the Murray-Darling Basin were determined over a one-year period. The most active exoenzyme was aminopeptidase, followed by alkaline phosphatase, lipase, N-acetyl beta-D-glucoaminidase, alpha-D-glucosidase and beta-D-glucosidase, beta-D-galactosidase and endopeptidase. Exoenzyme activity in rivers (alkaline phosphatase, 0.9-8.2 micromoles/L/day; aminopeptidase, 3.5-32 micromoles/L/day) was within the range reported for Northern-Hemisphere systems, but activity in billabongs (alkaline phosphatase, 4.4-222 micromoles/L/day; aminopeptidase, 8.7-1134 micromoles/L/day) was generally higher than that in rivers and other previously studied systems. Strong relationships were detected between aminopeptidase activity, chlorophyll-a concentrations, bacterial numbers and concentrations of ammonium and dissolved primary amines in the billabong. These interactions were not evident in the river. There were few clear relationships between alkaline phosphatase activity and environmental conditions in either billabong or river.
Magnetic Helicity and Free Magnetic Energy as Tools to Probe Eruptions in two Differently Evolving Solar Active Regions
Creators: name: Liokati, E.
name: Nindos, A.
name: Georgoulis, M. K.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Using vector magnetograms from the HMI/SDO and a magnetic connectivity-based method, we calculate the instantaneous relative magnetic helicity and free magnetic energy budgets for several days in two solar active regions (ARs), AR11890 and AR11618, both with complex photospheric magnetic field configurations. The ARs produced several major eruptive flares while their photospheric magnetic field exhibited primarily flux decay in AR11890 and primarily flux emergence in AR11618. Throughout much of their evolution both ARs featured substantial budgets of free magnetic energy and of both positive and negative helicity. In fact, the imbalance between the signed components of their helicity was as low as in the quiet Sun and their net helicity eventually changed sign 14-19 hours after their last major flare. Despite such incoherence, the eruptions occurred at times of net helicity peaks that were co-temporal with peaks in the free magnetic energy. The losses associated with the eruptive flares in the normalized free magnetic energy were in the range 10-60%. For the helicity, changes ranged from 25% to the removal of the entire excess helicity of the prevailing sign, leading a roughly zero net helicity, but with significant equal and opposite budgets of both helicity senses. The removal of the slowly varying background component of the free energy and helicity timeseries revealed that all eruption-related peaks of both quantities exceeded the 2$σ$ levels of their detrended timeseries. There was no eruption when only one or none of these quantities exceeded its 2$σ$ level. Our results indicate that differently evolving ARs may produce major eruptive flares even when, in addition to the accumulation of significant free magnetic energy budgets, they accumulate large amounts of both negative and positive helicity without a strong dominance of one handedness over the other.
description: 17 pages, 11 figures, accepted for publication in Astronomy & Astrophysics (abbreviated abstract)
Tumor Viruses and Cell Signaling Pathways: Deubiquitination versus Ubiquitination
Creators: name: Pagano, J. S.
name: Shackelford, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: In spite of differences among human oncogenic DNA viruses, there are some common characteristics. The viral genome persists in host cells and expresses latent gene products, and the strategy of cell transformation is generally the same: tumor viruses target cell signaling pathways. The goal of oncogenic viruses is obvious: to protract cell cycle progression and protect cells from apoptosis, thus perpetuating the virus genome. Therefore, the common cellular targets for tumor virus oncoproteins are the most important transcriptional factors involved in oncogenesis, such as c-myc, NF-κB, AP-1, p53, and others (62). Because there are innumerable cellular pathways that can regulate the transcriptional machinery of the cell, there are many opportunities for tumor viruses to dysregulate them to the benefit of the virus. It would not be surprising if any cell signaling pathway implicated in oncogenesis could be corrupted by oncogenic viruses.
Tidal Waves in $^{102}$Pd: A Phenomenological Analysis
Creators: name: Macchiavelli, A. O.
name: Ayangeakaa, A. D.
name: Frauendorf, S.
name: Garg, U.
name: Caprio, M. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Rotational and electromagnetic properties of the yrast band in $^{102}$Pd are analyzed in terms of a phenomenological phonon model that includes anharmonic terms. Both the moment of inertia and $B(E2)$'s are well reproduced by the model, providing an independent confirmation of the multi-phonon picture recently proposed. The (empirical) dependence of the phonon-phonon interaction on the phonon frequency, in Ru, Pd, and Ru isotopes, follows the expectations from particle-vibration coupling.
description: 3 pages, 2 figures. To be published in Phys. Rev. C
A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100
Creators: name: Purdy, M.
name: Dominski, Z.
name: Wagner, E. J.
name: Marzluff, W. F.
name: Yang, X.-c.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Formation of the mature 3′ ends of the vast majority of cellular mRNAs occurs through cleavage and polyadenylation and requires a cleavage and polyadenylation specificity factor (CPSF) containing, among other proteins, CPSF-73 and CPSF-100. These two proteins belong to a superfamily of zinc-dependent β-lactamase fold proteins with catalytic specificity for a wide range of substrates including nucleic acids. CPSF-73 contains a zinc-binding histidine motif involved in catalysis in other members of the β-lactamase superfamily, whereas CPSF-100 has substitutions within the histidine motif and thus is unlikely to be catalytically active. Here we describe two previously unknown human proteins, designated RC-68 and RC-74, which are related to CPSF-73 and CPSF-100 and which form a complex in HeLa and mouse cells. RC-68 contains the intact histidine motif, and hence it might be a functional counterpart of CPSF-73, whereas RC-74 lacks this motif, thus resembling CPSF-100. In HeLa cells RC-68 is present in both the cytoplasm and the nucleus whereas RC-74 is exclusively nuclear. RC-74 does not interact with CPSF-73, and neither RC-68 nor RC-74 is found in a complex with CPSF-160, indicating that these two proteins form a separate entity independent of the CPSF complex and are likely involved in a pre-mRNA processing event other than cleavage and polyadenylation of the vast majority of cellular pre-mRNAs. RNA interference-mediated depletion of RC-68 arrests HeLa cells early in G1 phase, but surprisingly the arrested cells continue growing and reach the size typical of G2 cells. RC-68 is highly conserved from plants to humans and may function in conjunction with RC-74 in the 3′ end processing of a distinct subset of cellular pre-mRNAs encoding proteins required for G1 progression and entry into S phase.
Applying of the Extreme Value Theory for determining extreme claims in the automobile insurance sector: Case of a China car insurance
Creators: name: Diawara, Daouda
name: Kane, Ladji
name: Dembele, Soumaila
name: Lo, Gane Samb
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences
subject: 62-07, 60G70, 62G32

description: According to the Chinese Health Statistics Yearbook, in 2005, the number of traffic accidents was 187781 with total direct property losses of 103691.7 (10000 Yuan). This research aims to fill the gap in the literature by investigating the extreme claim sizes not only for the entire portfolio. This empirical study investigates the behavior of the upper tail of the claim size by class of policyholders.
GEOGRAFIK KO'RSATKICHLAR XALQARO MUHOFAZASI
Creators: name: Ochilova, Zilola
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada geografik ko‘rsatkichlar tushunchasi, geografik ko‘rsatkichlar bilan tovar kelib chiqqan joy nomlarining farqli va o‘xshash jihatlari, geografik ko‘rsatkichlarni huquqiy jihatdan muhofaza qilish, shuningdek, geografik ko‘rsatkichlar xorijiy muhofazasi,geografik ko‘rsatkichlarnng ro‘yxatdan o‘tishini va muhofazasini tartibga soluvchi xalqaro shartnomalar o‘z tahlilini topgan.
A Dominant Interfering Bub1 Mutant Is Insufficient To Induce or Alter Thymic Tumorigenesis In Vivo, Even in a Sensitized Genetic Background
Creators: name: Van Dyke, T.
name: Cowley, D. O.
name: Muse, G. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Aneuploidy is a common feature of human tumors, often correlating with poor prognosis. The mitotic spindle checkpoint is thought to play a major role in aneuploidy suppression. To investigate the role of the spindle checkpoint in tumor suppression in vivo, we developed transgenic mice in which thymocytes express a dominant interfering fragment of Bub1, a kinase regulator of the spindle checkpoint. We report that, despite high-level expression of dominant-negative Bub1 (Bub1DN), a protein known to inhibit spindle checkpoint activity in cultured cells, thymocytes show no evidence of spindle checkpoint impairment. Transgenic animals also failed to show an increased predisposition to spontaneous tumors. Moreover, the Bub1DN transgene failed to alter the timing or characteristics of thymic lymphoma development in p53 heterozygous or homozygous null backgrounds, indicating that the lack of tumorigenesis is not due to suppression by p53-dependent checkpoints. These results indicate that overexpression of a Bub1 N-terminal fragment is insufficient to impair the spindle checkpoint in vivo or to drive tumorigenesis in the highly susceptible murine thymocyte system, either alone or in combination with G1 checkpoint disruption.
Rotifera from Australian inland waters V. Lecanidae (Rotifera: Monogononta)
Creators: name: Koste, W
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Diagnostic keys are given to the genera and species of the rotifer family Lecanidae (Hemimonostyla, Monostyla, Lecane) recorded from Australian inland waters. All species are figured and available distribution data and ecological information are given. Some widely distributed taxa not yet recorded from the continent are included.
The chemical DNA of the Magellanic Clouds -- I. The chemical composition of 206 Small Magellanic Cloud red giant stars
Creators: name: Mucciarelli, A.
name: Minelli, A.
name: Bellazzini, M.
name: Lardo, C.
name: Romano, D.
name: Origlia, L.
name: Ferraro, F. R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the chemical composition of 206 red giant branch stars members of the Small Magellanic Cloud (SMC) using optical, high-resolution spectra collected with the multi-object spectrograph FLAMES-GIRAFFE at the ESO Very Large Telescope. This sample includes stars in three fields located in different positions within the parent galaxy. We analysed the main groups of elements, namely light- (Na), alpha- (O, Mg, Si, Ca, Ti), iron-peak (Sc, V, Fe, Ni, Cu) and s-process elements (Zr, Ba, La). The metallicity distribution of the sample displays a main peak around [Fe/H] ~ -1 dex and a weak metal-poor tail. However, the three fields display [Fe/H] distributions different with each other, in particular a difference of 0.2 dex is found between the mean metallicities of the two most internal fields.The fraction of metal-poor stars increases significantly (from ~1 to ~20%) from the innermost fields to the most external one, likely reflecting an age gradient in the SMC. Also, we found a hint of possible chemically/kinematic distinct substructures. The SMC stars have abundance ratios clearly distinct with respect to the Milky Way stars, in particular for the elements produced by massive stars (like Na, $α$ and most iron-peak elements) that have abundance ratios systematically lower than those measured in our Galaxy. This points out that the massive stars contributed less to the chemical enrichment of the SMC with respect to the Milky Way, according to the low star formation rate expected for this galaxy. Finally, we identified small systematic differences in the abundances of some elements (Na, Ti, V and Zr) in the two innermost fields, suggesting that the chemical enrichment history in the SMC has been not uniform.
description: 16 pages, 11 figures, 5 tables. Accepted for publication in Astronomy and Astrophysics
Fluidic Topology Optimization with an Anisotropic Mixture Model
Creators: name: Li, Yifei
name: Du, Tao
name: Srinivasan, Sangeetha Grama
name: Wu, Kui
name: Zhu, Bo
name: Sifakis, Eftychios
name: Matusik, Wojciech
Publisher: name: arXiv
Year: 2022
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: Fluidic devices are crucial components in many industrial applications involving fluid mechanics. Computational design of a high-performance fluidic system faces multifaceted challenges regarding its geometric representation and physical accuracy. We present a novel topology optimization method to design fluidic devices in a Stokes flow context. Our approach is featured by its capability in accommodating a broad spectrum of boundary conditions at the solid-fluid interface. Our key contribution is an anisotropic and differentiable constitutive model that unifies the representation of different phases and boundary conditions in a Stokes model, enabling a topology optimization method that can synthesize novel structures with accurate boundary conditions from a background grid discretization. We demonstrate the efficacy of our approach by conducting several fluidic system design tasks with over four million design parameters.
description: Accepted by SIGGRAPH Asia 2022. For low resolution paper see https://people.csail.mit.edu/liyifei/publication/anisotropic-stokes-fluidic-device/
Revisión de alcance de las terapias para el accidente cerebrovascular isquémico agudo dentro de las primeras 4.5 horas en la prognosis de pacientes con hemiplejia.
Creators: name: Carrillo Navarrete, Karen Adriana
Publisher: name: Zenodo
Year: 2022
Subjects: NIHSS
Stroke
Brain
mRs
Therapy

description: Revisión de alcance de las terapias para el accidente cerebrovascular isquémico agudo dentro de las primeras 4.5 horas en la prognosis de pacientes con hemiplejia.
Deflected propagation of a coronal mass ejection from the corona to interplanetary space
Creators: name: Wang, Yuming
name: Wang, Boyi
name: Shen, Chenglong
name: Shen, Fang
name: Lugaz, Noe
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Among various factors affecting the space weather effects of a coronal mass ejection (CME), its propagation trajectory in the interplanetary space is an important one determining whether and when the CME will hit the Earth. Many direct observations have revealed that a CME may not propagate along a straight trajectory in the corona, but whether or not a CME also experiences a deflected propagation in the interplanetary space is a question, which has never been fully answered. Here by investigating the propagation process of an isolated CME from the corona to interplanetary space during 2008 September 12 -- 19, we present solid evidence that the CME was deflected not only in the corona but also in the interplanetary space. The deflection angle in the interplanetary space is more than 20 degrees toward the west, resulting a significant change in the probability the CME encounters the Earth. A further modeling and simulation-based analysis suggest that the cause of the deflection in the interplanetary space is the interaction between the CME and the solar wind, which is different from that happening in the corona.
description: 15 pages, 17 figures, accepted by JGR
Rotifera from Australian inland waters VI. Proalidae, Lindiidae (Rotifera: Monogononta)
Creators: name: Koste, W
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Keys are given to the genera and species of the Rotifera: Monogononta of the families Proalidae (four genera) and Lindiidae (one genus). The proalid genus Wulfertia is not know from Australia, and a single record of Bryceella is doubtful. Two species of Proalinopsis and ten species of Proales are known from AAustralian inland waters. Proales similis exoculis (Berzins, 1953) is suppressed. Five species of the lindiid genus Lindia are confirmed, with a sixth, known from New Zealand, doubtful. All species of this genera recorded from Australian waters are described and figured with known distribution data and ecological information. Brief comments are included on current rotifer taxonomy and biogeography.
A Novel Domain in Set2 Mediates RNA Polymerase II Interaction and Couples Histone H3 K36 Methylation with Transcript Elongation
Creators: name: Hall, H.
name: Shibata, Y.
name: Kizer, K. O.
name: Greenleaf, A. L.
name: Strahl, B. D.
name: Phatnani, H. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Histone methylation and the enzymes that mediate it are important regulators of chromatin structure and gene transcription. In particular, the histone H3 lysine 36 (K36) methyltransferase Set2 has recently been shown to associate with the phosphorylated C-terminal domain (CTD) of RNA polymerase II (RNAPII), implying that this enzyme has an important role in the transcription elongation process. Here we show that a novel domain in the C terminus of Set2 is responsible for interaction between Set2 and RNAPII. This domain, termed the Set2 Rpb1 interacting (SRI) domain, is encompassed by amino acid residues 619 to 718 in Set2 and is found to occur in a number of putative Set2 homologs from Schizosaccharomyces pombe to humans. Unexpectedly, BIACORE analysis reveals that the SRI domain binds specifically, and with high affinity, to CTD repeats that are doubly modified (serine 2 and serine 5 phosphorylated), indicating that Set2 association across the body of genes requires a specific pattern of phosphorylated RNAPII. Deletion of the SRI domain not only abolishes Set2-RNAPII interaction but also abolishes K36 methylation in vivo, indicating that this interaction is required for establishing K36 methylation on chromatin. Using 6-azauracil (6AU) as an indicator of transcription elongation defects, we found that deletion of the SRI domain conferred a strong resistance to this compound, which was identical to that observed with set2 deletion mutants. Furthermore, yeast strains carrying set2 alleles that are catalytically inactive or yeast strains bearing point mutations at K36 were also found to be resistant to 6AU. These data suggest that it is the methylation by Set2 that affects transcription elongation. In agreement with this, we have determined that deletion of SET2, its SRI domain, or amino acid substitutions at K36 result in an alteration of RNAPII occupancy levels over transcribing genes. Taken together, these data indicate K36 methylation, established by the SRI domain-mediated association of Set2 with RNAPII, plays an important role in the transcription elongation process.
On x-independence of RQ = FLQ/F2Q ratio at low x
Creators: name: Abdulov, N. A.
name: Kotikov, A. V.
name: Lipatov, A. V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We give predictions for the ratio RQ(x,Q2)=FLQ(x,Q2)/F2Q(x,Q2) at small values of Bjorken variable x in the first three orders of perturbation theory. We show an approximate x-independence of RQ(x,Q2) at low x and non-large Q2 values (Q2 < 8--10 m2Q), irrespectively on the gluon density in a proton used in the calculations. This observation could be useful in subsequent phenomenological studies of the heavy flavor production at future lepton-hadron and hadron-hadron colliders.
description: 10 pages, 3 figures,