cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 4 of Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study
Creators: name: Oeyen, Sandra
name: De Corte, Wouter
name: Benoit, Dominique
name: Annemans, Lieven
name: Dhondt, Annemieke
name: Vanholder, Raymond
name: Decruyenaere, Johan
name: Hoste, Eric
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Variability in SF-36. In this additional file, more detailed information is given regarding variability of the SF-36 at the different time points in the 1-year cohort and 4-year cohort. Median norm-based scores with interquartile ranges on the different domains of the SF-36 over time are given in a table. (PDF 81 kb)
Le dénouement de la Révolution française
Creators: name: Debauve, Bernard-Simon-Laurent
Publisher: name: Paris : Cocheris, Imprimeur-Libraire, Deroy, Libraire, Ponthieu, Libraire, et chez tous les Marchands de Nouveaut�s
Year: 2023

description: A pamphlet bound with glue and repaired on the spine, containing "Le dénouement de la Révolution française; Par B.S.L. Debauve." The pamphlet was published in Paris and available "chez Cocheris, Imprimeur-Libraire, cloître Benoît, No. 352, section des Thermes, Deroy, Libraire, rue du Cimetière-Saint-André, No.15, Ponthieu, Libraire, rue Saint-Jacques, vis-à-vis la place Cambrai, No. 652, et chez tous les Marchands de Nouveautés."
Additional file 2 of Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study
Creators: name: Oeyen, Sandra
name: De Corte, Wouter
name: Benoit, Dominique
name: Annemans, Lieven
name: Dhondt, Annemieke
name: Vanholder, Raymond
name: Decruyenaere, Johan
name: Hoste, Eric
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: SF-36 assessments over time. In this additional file, evolutions in SF-36 assessments are described through figures in the 1-year cohort (47 AKI-RRT (A) and 94 non-AKI-RRT patients (B)) and in the 4-year cohort (28 AKI-RRT (C) patients and 28 non-AKI-RRT patients (D)). Percentages of patients with some or severe problems in the different domains of the SF-36 are given over the different time points: baseline, 3 months and 1 year (1-year cohort) and baseline, 3 months, 1 year and 4 years (4-year cohort). (PDF 126 kb)
Evaluation of anticancer potential of tetracene-5,12-dione (A01) and pyrimidine-2,4-dione (A02) via caspase 3 and lactate dehydrogenase cytotoxicity investigations
Creators: name: Aziz, Mubashir
name: Sarfraz, Muhammad
name: Khurrum Ibrahim, Muhammad
name: Ejaz, Syeda Abida
name: Zehra, Tasneem
name: Ogaly, Hanan A.
name: Arafat, Mosab
name: Al-Zahrani, Fatimah A. M.
name: Li, Chen
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Breast cancer
subject: Drug interactions
subject: Transcription factors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Cancer stands as a significant global cause of mortality, predominantly arising from the dysregulation of key enzymes and DNA. One strategic avenue in developing new anticancer agents involves targeting specific proteins within the cancer pathway. Amidst ongoing efforts to enhance the efficacy of anticancer drugs, a range of crucial medications currently interact with DNA at the molecular level, exerting profound biological effects. Our study is driven by the objective to comprehensively explore the potential of two compounds: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione (A01) and 5-fluoro-1H-pyrimidine-2,4-dione (A02). These compounds have demonstrated marked efficacy against breast and cervical cancer cell lines, positioning them as promising anticancer candidates. In our investigation, A01 has emerged as a particularly potent candidate, with its potential bolstered by corroborative evidence from lactate dehydrogenase release and caspase-3 activity assays. On the other hand, A02 has exhibited remarkable anticancer potential. To further elucidate their molecular mechanisms and interactions, we employed computational techniques, including molecular docking and molecular dynamics simulations. Notably, our computational analyses suggest that the A01-DNA complex predominantly interacts via the minor groove, imparting significant insights into its mechanism of action. While earlier studies have also highlighted the anticancer activity of A01, our research contributes by providing a deeper understanding of its binding mechanisms through computational investigations. This knowledge holds potential for designing more effective drugs that target cancer-associated proteins. These findings lay a robust groundwork for future inquiries and propose that derivatives of A01 could be synthesized as potent bioactive agents for cancer treatment. By elucidating the distinctive aspects of our study’s outcomes, we address the concern of distinguishing our findings from those of prior research.
Additional file 1 of The COVID-19 pandemic in francophone West Africa: from the first cases to responses in seven countries
Creators: name: Bonnet, E.
name: Bodson, O.
name: Le Marcis, F.
name: Faye, A.
name: Sambieni, N. E.
name: Fournet, F.
name: Boyer, F.
name: Coulibaly, A.
name: Kadio, K.
name: Diongue, F. B.
name: Ridde, V.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1. Updated Covid-19 data July 2021.
Diffusion-plus-drift models for the mass leakage from centrifugal magnetospheres of magnetic hot-stars
Creators: name: Owocki, Stanley P.
name: Cranmer, Steven R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In the subset of luminous, early-type stars with strong, large-scale magnetic fields and moderate to rapid rotation, material from the star's radiatively driven stellar wind outflow becomes trapped by closed magnetic loops, forming a centrifugally supported, co-rotating magnetosphere. We present here a semi-analytic analysis of how this quasi-steady accumulation of wind mass can be balanced by losses associated with a combination of an outward, centrifugally driven drift in the region beyond the Kepler co-rotation radius, and an inward/outward diffusion near this radius. We thereby derive scaling relations for the equilibrium spatial distribution of mass, and the associated emission measure for observational diagnostics like Balmer line emission. We discuss the potential application of these relations for interpreting surveys of the emission line diagnostics for OB stars with centrifugally supported magnetospheres. For a specific model of turbulent field-line-wandering rooted in surface motions associated with the iron opacity bump, we estimate values for the associated diffusion and drift coefficients.
description: 11 pages, 5 figures, accepted by MNRAS
Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.
Creators: name: Bichismita  Sahu
name: Sacui, Iulia
name: Rapireddy, Srinivas
name: Zanotti, Kimberly J.
name: Bahal, Raman
name: Armitage, Bruce
name: Danith Ly
Publisher: name: Carnegie Mellon University
Year: 2011
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Developed in the early 1990s, peptide nucleic acid (PNA) has emerged as a promising class of nucleic acid mimic because of its strong binding affinity and sequence selectivity toward DNA and RNA and resistance to enzymatic degradation by proteases and nucleases; however, the main drawbacks, as compared to other classes of oligonucleotides, are water solubility and biocompatibility. Herein we show that installation of a relatively small, hydrophilic (R)-diethylene glycol ("miniPEG", R-MP) unit at the γ-backbone transforms a randomly folded PNA into a right-handed helix. Synthesis of optically pure (R-MP)γPNA monomers is described, which can be accomplished in a few simple steps from a commercially available and relatively cheap Boc-l-serine. Once synthesized, (R-MP)γPNA oligomers are preorganized into a right-handed helix, hybridize to DNA and RNA with greater affinity and sequence selectivity, and are more water soluble and less aggregating than the parental PNA oligomers. The results presented herein have important implications for the future design and application of PNA in biology, biotechnology, and medicine, as well as in other disciplines, including drug discovery and molecular engineering.
Toric G_2 and Spin(7) holonomy spaces from gravitational instantons and other examples
Creators: name: Giribet, Gaston
name: Santillan, Osvaldo P.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Non-compact G_2 holonomy metrics that arise from a T^2 bundle over a hyper-Kahler space are discussed. These are one parameter deformations of the metrics studied by Gibbons, Lu, Pope and Stelle in hep-th/0108191. Seven-dimensional spaces with G_2 holonomy fibered over the Taub-Nut and the Eguchi-Hanson gravitational instantons are found, together with other examples. By considering the Apostolov-Salamon theorem math.DG/0303197, we construct a new example that, still being a T^2 bundle over hyper-Kahler, represents a non trivial two parameter deformation of the metrics studied in hep-th/0108191. We then review the Spin(7) metrics arising from a T^3 bundle over a hyper-Kahler and we find two parameter deformation of such spaces as well. We show that if the hyper-Kahler base satisfies certain properties, a non trivial three parameter deformations is also possible. The relation between these spaces with the half-flat structures and almost G_2 holonomy spaces is briefly discussed.
description: 27 pages. Typos corrected. Accepted for publication in Commun.Math.Phys
Breakdown by a magnetic field of the superconducting fluctuations in the normal state: A simple phenomenological explanation
Creators: name: Ramallo, Manuel V.
name: Mosqueira, Jesus
name: Carballeira, Carlos
name: Soto, Felix
name: Vidal, Felix
Publisher: name: arXiv
Year: 2006
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We first summarize our recent observations, through magnetization measurements in different low-Tc superconductors, of a rather sharp disappearance of the superconducting fluctuations in the normal state when the magnetic field approaches Hc2(0), the upper critical field extrapolated to T=0K. We propose that a crude phenomenological description of the observed effects may be obtained if the quantum limits associated with the uncertainty principle are introduced in the Gaussian-Ginzburg-Landau description of the fluctuation-induced magnetization.
description: LaTeX, 8 pages, including 2 eps figures. Proceedings of SNS'04, Sitges, Spain
Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice
Creators: name: Dogra, Tanya
name: Pelz, Lars
name: Boehme, Julia D.
name: Kuechler, Jan
name: Kershaw, Olivia
name: Marichal-Gallardo, Pavel
name: Baelkner, Maike
name: Hein, Marc D.
name: Gruber, Achim D.
name: Benndorf, Dirk
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: biotechnology
subject: molecular biology
subject: OP7 chimera
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Influenza A virus (IAV) defective interfering particles (DIPs) are considered as new promising antiviral agents. Conventional DIPs (cDIPs) contain a deletion in the genome and can only replicate upon co-infection with infectious standard virus (STV), during which they suppress STV replication. We previously discovered a new type of IAV DIP “OP7” that entails genomic point mutations and displays higher antiviral efficacy than cDIPs. To avoid safety concerns for the medical use of OP7 preparations, we developed a production system that does not depend on infectious IAV. We reconstituted a mixture of DIPs consisting of cDIPs and OP7 chimera DIPs, in which both harbor a deletion in their genome. To complement the defect, the deleted viral protein is expressed by the suspension cell line used for production in shake flasks. Here, DIP preparations harvested are not contaminated with infectious virions, and the fraction of OP7 chimera DIPs depended on the multiplicity of infection. Intranasal administration of OP7 chimera DIP material was well tolerated in mice. A rescue from an otherwise lethal IAV infection and no signs of disease upon OP7 chimera DIP co-infection demonstrated the remarkable antiviral efficacy. The clinical development of this new class of broad-spectrum antiviral may contribute to pandemic preparedness.
Additional file 2 of The COVID-19 pandemic in francophone West Africa: from the first cases to responses in seven countries
Creators: name: Bonnet, E.
name: Bodson, O.
name: Le Marcis, F.
name: Faye, A.
name: Sambieni, N. E.
name: Fournet, F.
name: Boyer, F.
name: Coulibaly, A.
name: Kadio, K.
name: Diongue, F. B.
name: Ridde, V.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 2. Timing of activities, by component and country.
Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.
Creators: name: Anisha  Gupta
name: Lee, Ling-Ling
name: Subhadeep  Roy
name: Farial A. Tanious
name: W. David  Wilson
name: Danith Ly
name: Armitage, Bruce
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Molecular recognition of DNA quadruplex structures is envisioned to be a strategy for regulating gene expression at the transcriptional level and for in situ analysis of telomere structure and function. The recognition of DNA quadruplexes by peptide nucleic acid (PNA) oligomers is presented here, with a focus on comparing complementary, heteroduplex-forming and homologous, heteroquadruplex-forming PNAs. Surface plasmon resonance and optical spectroscopy experiments demonstrated that the efficacy of a recognition mode depended strongly on the target. Homologous PNA readily invades a quadruplex derived from the promoter regulatory region found upstream of the MYC proto-oncogene to form a heteroquadruplex at high potassium concentration mimicking the intracellular environment, whereas complementary PNA exhibits virtually no hybridization. In contrast, complementary PNA is superior to the homologous in hybridizing to a quadruplex modeled on the human telomere sequence. The results are discussed in terms of the different structural morphologies of the quadruplex targets and the implications for in vivo recognition of quadruplexes by PNAs.
Funneling with the Two-Beam RFQ
Creators: name: Zimmermann, H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: New high current accelerator facilities like proposed for HIDIF or ESS require a beam with a high brilliance. These beams can not be produced by a single pass rf-linac. The increase in brightness in such a driver linac is done by several funneling stages at low energies, in which two identically bunched ion beams are combined into a single beam with twice the frequency current and brightness. Our Two-Beam-RFQ funneling experiment is a setup of two ion sources, a two beam RFQ, a funnel deflector and beam diagnostic equipment to demonstrate funneling of ion beams as a model for the first funneling stage of a HIIF driver. The progress of the funneling experiment and results of simulations will be presented.
description: 3 pages, 11 figures
Lower limits on the nucleosynthezis of $^{44}$Ti and $^{60}$Fe in the dynamic spiral-arms model
Creators: name: Benyamin, David
name: Shaviv, Nir J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We have previously focused on studying the electron-capture isotopes within the dynamic spiral-arms model and empirically derived the energy dependence of the electron attachment rate using the observation of $^{49}$Ti/$^{49}$V and $^{51}$V/$^{51}$Cr ratios in cosmic rays (Benyamin et al. 2017). We have also shown how this relation recovers the energy dependence seen in the lab measurements (Letaw et al. 1985). In this work we use this relation to construct the $^{44}$Ca/$^{44}$Ti ratio and place a lower limit on the amount of $^{44}$Ti that is required to be nucleosynthesized at the source. The results also imply that the acceleration process of the radioisotopes cannot be much longer than a century time scale (or else the required nucleosynthesized amount has to be correspondingly larger). We also provide a similar lower limit on the source $^{60}$Fe by comparing to the recently observed $^{60}$Fe/$^{56}$Fe (Binns et al. 2016).
Factors Influencing Consumer Buying Behavior Towards Online Shopping in Sultanate of Oman
Creators: name: Hussain, Sajjad
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 350601
subject: Consumer behaviour
classificationCode: 350604
subject: Marketing communications
classificationCode: 350605
subject: Marketing management (incl. strategy and customer relations)

description: The fundamental objective of any business is to reach and engage the clients and converting them to purchase from you and the secret key to do it is to understand the consumer buying behavior. (Valentin Radu, 2019) Consumers use and consume things of daily use according to their needs and wants which depend upon their preferences and purchase power. Apart from their purchase power, there are other factors also which influence their buying behavior toward online shopping. In this paper, the profile of OMAN’s online business industry has been discussed in detail. Utilization of web and infiltration in Oman, Internet, e-commerce and late drivers of web-based business in Oman. Also, the difficulties of this Internet-related industry, level of trust, quality of the website, convenience and role of promotion and advertisement In last few years many key player in online market has come into Oman market which has changed the landscape of traditional trade and also influence the consumer buying behavior such as Talabat, TMdone, Akeed, Carrefour and lulu online delivery system which shows that brand-conscious residents are ordering lifestyle products, Price conscious customers has increased since COVID 19. How difference categories home care, Personal care, Food & beverages, OTC, and Tabaco is performing in traditional/modern trade and online trade. Women shopper’s behavior becoming web-savvy, Technology and internet has increased the opportunities to both buyers and sellers to fine and innovate the ways of shopping and shipping. The Internet is attracting the customer of retail market. The overall footfall has decreased in Oman Modern trade market. Apart from stable Population, an increased number of retail markets there is one of the biggest reasons which is internet shopping. That’s why it is very important to know the factors that influence the buying behavior of customers.
Additional file 3 of The COVID-19 pandemic in francophone West Africa: from the first cases to responses in seven countries
Creators: name: Bonnet, E.
name: Bodson, O.
name: Le Marcis, F.
name: Faye, A.
name: Sambieni, N. E.
name: Fournet, F.
name: Boyer, F.
name: Coulibaly, A.
name: Kadio, K.
name: Diongue, F. B.
name: Ridde, V.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 3. Some Pandemic Monitoring and Management Bodies.
Brane Decay of a (4+n)-Dimensional Rotating Black Hole. III: spin-1/2 particles
Creators: name: Casals, M.
name: Dolan, S. R.
name: Kanti, P.
name: Winstanley, E.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work, we have continued the study of the Hawking radiation on the brane from a higher-dimensional rotating black hole by investigating the emission of fermionic modes. A comprehensive analysis is performed that leads to the particle, power and angular momentum emission rates, and sheds light on their dependence on fundamental parameters of the theory, such as the spacetime dimension and angular momentum of the black hole. In addition, the angular distribution of the emitted modes, in terms of the number of particles and energy, is thoroughly studied. Our results are valid for arbitrary values of the energy of the emitted particles, dimension of spacetime and angular momentum of the black hole, and complement previous results on the emission of brane-localised scalars and gauge bosons.
description: Latex file, JHEP style, 34 pages, 16 figures Energy range in plots increased, minor changes, version published in JHEP
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00407
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00407, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: abbaye de Cîteaux
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.
Creators: name: Subhadeep  Roy
name: Zanotti, Kimberly J.
name: Murphy, Connor T.
name: Farial A. Tanious
name: W. David  Wilson
name: Danith Ly
name: Armitage, Bruce
Publisher: name: Carnegie Mellon University
Year: 2011
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.
Signed and unsigned effects of prediction error on memory: Is it a matter of choice?
Creators: name: Pupillo, Francesco
name: Bruckner, Rasmus
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Prediction error
subject: Episodic memory
subject: Computational models
subject: Choice-confirmation bias
subject: Positivity bias
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Adaptive decision-making is governed by at least two types of memory processes. On the one hand, learned predictions through integrating multiple experiences, and on the other hand, one-shot episodic memories. These two processes interact, and predictions – particularly prediction errors – influence how episodic memories are encoded. However, studies using computational models disagree on the exact shape of this relationship, with some findings showing an effect of signed prediction errors and others showing an effect of unsigned prediction errors on episodic memory. We argue that the choice-confirmation bias, which reflects stronger learning from choice-confirming compared to disconfirming outcomes, could explain these seemingly diverging results. Our perspective implies that the influence of prediction errors on episodic encoding critically depends on whether people can freely choose between options (i.e., instrumental learning tasks) or not (Pavlovian learning tasks). The choice-confirmation bias on memory encoding might have evolved to prioritize memory representations that optimize reward-guided decision-making. We conclude by discussing open issues and implications for future studies.
Additional file 4 of The COVID-19 pandemic in francophone West Africa: from the first cases to responses in seven countries
Creators: name: Bonnet, E.
name: Bodson, O.
name: Le Marcis, F.
name: Faye, A.
name: Sambieni, N. E.
name: Fournet, F.
name: Boyer, F.
name: Coulibaly, A.
name: Kadio, K.
name: Diongue, F. B.
name: Ridde, V.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 4. Updated Covid-19 data (July 2021).
Comment on "Non-Mean-Field Behavior of the Contact Process on Scale-Free Networks"
Creators: name: Ha, Meesoon
name: Hong, Hyunsuk
name: Park, Hyunggyu
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Recently, Castellano and Pastor-Satorras [1] utilized the finite size scaling (FSS) theory to analyze simulation data for the contact process (CP) on scale-free networks (SFNs) and claimed that its absorbing critical behavior is not consistent with the mean-field (MF) prediction. Furthermore, they pointed out large density fluctuations at highly connected vertices as a possible origin for non-MF critical behavior. In this Comment, we propose a scaling theory for relative density fluctuations in the spirit of the MF theory, which turns out to explain simulation data perfectly well. We also measure the value of the critical density decay exponent, which agrees well with the MF prediction. Our results strongly support that the CP on SFNs still exhibits a MF-type critical behavior.
description: 1 page, 2 figures, typos are corrected
Additional file 1: of Insights into the impact of flhF inactivation on Campylobacter jejuni colonization of chick and mice gut
Creators: name: Ren, Fangzhe
name: Li, Xiaofei
name: Tang, Haiyan
name: Jiang, Qidong
name: Yun, Xi
name: Fang, Lin
name: Huang, Pingyu
name: Tang, Yuanyue
name: Li, Qiuchun
name: Huang, Jinlin
name: Jiao, Xin-an
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. Identification of the C. jejuni isolate. Table S1. Primers used in this study. Table S2. The relative mRNA expression of other infection-related genes in the microarray assay. Table S3. The biochemical characteristics of C. jejuni strains. (DOCX 243 kb)
Pesticides in Agricultural Soils: Major Findings from Various Monitoring Campaigns in Switzerland
Creators: name: Bucheli, Thomas D.
name: Barmettler, Elias
name: Bartolomé, Nora
name: Hilber, Isabel
name: Hornak, Karel
name: Meuli, Reto G.
name: Reininger, Vanessa
name: Riedo, Judith
name: Rösch, Andrea
name: Sutter, Philipp
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Micropollutants
subject: Plant protection products
subject: Swiss National Soil Monitoring Program
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Synthetic pesticides are widely applied in modern agriculture, where they are used against diseases, pests, and weeds to secure crop yield and quality. However, their intensive application has led to widespread contamination of the environment, including soils. Due to their inherent toxicity, they might pose a risk to soil health by causing harm to non-target organisms and disrupting ecosystem services in both agricultural and other exposed soils. Following the Swiss National Action Plan on the reduction of pesticide risks, Agroscope has conducted several soil monitoring studies that are briefly presented here. All of them resort to different multi-residue trace analytical approaches to simultaneously quantify up to about 150 modern pesticides by either accelerated solvent, or Quick, Easy, Cheap, Efficient, Rugged, Safe (QuEChERS) extraction, followed by separation and detection with liquid chromatography-triple quadrupole mass spectrometry. While partly still in progress, our investigations led to the following major findings this far: Multiple pesticides are commonly present in soils, with individual concentrations in agricultural soils often reaching up to a few tens of µg/kg. Pesticide occurrence and concentrations in agricultural soils primarily depend on land use, land use history and cultivated crops. Pesticides can prevail much longer than predicted by their half-lives, and were found in soils even decades after conversion from conventional to organic farming. Corresponding residual fractions can be in the order of a few percent of the originally applied amounts. We further found negative associations of pesticide residues with the abundance of beneficial soil life, underpinning their potential risk to the fertility of agricultural soils. Traces of pesticides are also detected in soils to which they were never applied, indicating contamination, e.g., via spray drift or atmospheric deposition. These results confirm the general notion of both scientists and legislators that prospective risk assessments (RA; as executed during registration and use authorization) should be confirmed and adjusted by retrospective RA (e.g., by environmental monitoring studies of currently used compounds) to jointly lead to an overall reduced environmental risk of pesticides.
Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.
Creators: name: Sufi M. Thomas
name: Bichismita  Sahu
name: Rapireddy, Srinivas
name: Bahal, Raman
name: Wheeler, Sarah E.
name: Procopio, Eva M.
name: Kim, Joseph
name: Joyce, Sonali C.
name: Contrucci, Sarah
name: Wang, Yun
name: Chiosea, Simion I.
name: Lathrop, Kira L.
name: Watkins, Simon
name: Grandis, Jennifer R.
name: Armitage, Bruce
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence selectivity toward DNA and RNA, and resistance to enzymatic degradation by proteases and nucleases. While they have been shown to be effective in regulation of gene expression in vitro, and to a small extent in vivo, their full potential for molecular therapy has not yet been fully realized due to poor cellular uptake. Herein, we report the development of cell-permeable, guanidine-based peptide nucleic acids targeting the epidermal growth factor receptor (EGFR) in preclinical models as therapeutic modality for head and neck squamous cell carcinoma (HNSCC) and nonsmall cell lung cancer (NSCLC). A GPNA oligomer, 16 nucleotides in length, designed to bind to EGFR gene transcript elicited potent antisense effects in HNSCC and NSCLC cells in preclinical models. When administered intraperitoneally in mice, EGFRAS-GPNA was taken-up by several tissues including the xenograft tumor. Systemic administration of EGFRAS-GPNA induced antitumor effects in HNSCC xenografts, with similar efficacies as the FDA-approved EGFR inhibitors: cetuximab and erlotinib. In addition to targeting wild-type EGFR, EGFRAS-GPNA is effective against the constitutively active EGFR vIII mutant implicated in cetuximab resistance. Our data reveals that GPNA is just as effective as a molecular platform for treating cetuximab resistant cells, demonstrating its utility in the treatment of cancer.
Overview of the APT Accelerator Design
Creators: name: Tooker, J. F.
name: Bourque, R.
name: Christiansen, D.
name: Kamperschroer, J.
name: Laughon, G.
name: McCarthy, M.
name: Schulze, M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The accelerator for the APT Project is a 100 mA CW proton linac with an output energy of 1030 MeV. A High Energy Beam Transport (HEBT) conveys the beam to a raster expander, that provides a large rectangular distribution at a target/blanket (T/B) assembly. Spallation neutrons generated by the proton beam in the T/B reacts with Helium-3 to produce tritium. The design of the APT linac is an integrated normal-conducting (NC)/superconducting (SC) proton linac; the machine architecture has been discussed elsewhere [1]. The NC linac consists of a 75 keV injector, a 6.7-MeV 350-MHz RFQ (radio frequency quadrupole), a 96-MeV 700-MHz CCDTL (coupled-cavity drift-tube linac), and a 700-MHz CCL (coupled-cavity linac), with an output energy of 211 MeV. This is followed by a SC linac, that employs 700-MHz elliptical niobium 5-cell cavities to accelerate the beam to the final energy. The SC linac has two sections, optimized for beam velocities of b =0.64 and b =0.82. Each section is made up of cryomodules containing two, three, or four 5-cell cavities, driven by 1-MW 700-MHz klystrons. The singlet FODO lattice in the NC linac transitions to a doublet focusing lattice in the SC linac, with conventional quadrupole magnets in the warm inter-module spaces. This doublet lattice is continued in the HEBT. An overview of the current linac design will be presented.
description: TUD06, Linac2000, 3 pages
Security of subcarrier wave quantum key distribution against the collective beam-splitting attack
Creators: name: Kozubov, A. V.
name: Gaidash, A. A.
name: Gleim, A. V.
name: Miroshnichenko, G. P.
name: Horoshko, D. B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a subcarrier wave quantum key distribution (QKD) system, where the quantum en- coding is carried by weak sidebands generated to a coherent optical beam by means of an electrooptic phase modulation. We study the security of two protocols, B92 and BB84, against one of the most powerful attacks on the systems of this class: the collective beam splitting attack. We show that a subcarrier wave QKD system with realistic parameters is capable of distributing a cryptographic key over large distances. We show also that a modification of the BB84 protocol, with discrimina- tion of only one state in each basis, performs not worse than the original BB84 protocol for this class of QKD systems, which brings a significant simplification to the development of cryprographic networks on the basis of considered technique.
The UBP5 histone H2A deubiquitinase counteracts PRCs-mediated repression to regulate Arabidopsis development
Creators: name: Godwin, James
name: Govindasamy, Mohan
name: Nedounsejian, Kiruba
name: March, Eduardo
name: Halton, Ronan
name: Bourbousse, Clara
name: Wolff, Léa
name: Fort, Antoine
name: Krzyszton, Michal
name: Schubert, Daniel
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Epigenetics
subject: Epigenomics
subject: Gene regulation
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Polycomb Repressive Complexes (PRCs) control gene expression through the incorporation of H2Aub and H3K27me3. In recent years, there is increasing evidence of the complexity of PRCs’ interaction networks and the interplay of these interactors with PRCs in epigenome reshaping, which is fundamental to understand gene regulatory mechanisms. Here, we identified UBIQUITIN SPECIFIC PROTEASE 5 (UBP5) as a chromatin player able to counteract the deposition of the two PRCs’ epigenetic hallmarks in Arabidopsis thaliana. We demonstrated that UBP5 is a plant developmental regulator based on functional analyses of ubp5-CRISPR Cas9 mutant plants. UBP5 promotes H2A monoubiquitination erasure, leading to transcriptional de-repression. Furthermore, preferential association of UBP5 at PRC2 recruiting motifs and local H3K27me3 gaining in ubp5 mutant plants suggest the existence of functional interplays between UBP5 and PRC2 in regulating epigenome dynamics. In summary, acting as an antagonist of the pivotal epigenetic repressive marks H2Aub and H3K27me3, UBP5 provides novel insights to disentangle the complex regulation of PRCs’ activities.
The multiphase nature of the intra-cluster medium of some clusters of galaxies
Creators: name: Bonamente, Max
name: Lieu, Richard
name: Mittaz, Jonathan P. D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The discovery of EUV and soft X-ray excess emission in clusters of galaxies (the cluster soft-excess phenomenon) challenged the notion of the hot ($\sim 10^{7-8}$ K) gas as the only dominant thermal component of the intracluster medium (ICM). The spatial analysis of ROSAT PSPC 1/4 keV images presented here reveals compelling evidence for substantial amounts of cold gas (HI) in the ICM of the Coma and Virgo clusters. This finding bolsters the original interpretation of the soft excess as emission from a `warm' ($\sim 10^6$ K) gas and points to the scenario of a multiphase ICM where the hot component co-exists with gases at sub-Virial temperatures (the `warm' and `cold' phases).
description: ApJ accepted
Additional file 1 of An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis
Creators: name: Oh, Sang Hoon
name: Oh, Joo Suk
name: Kim, Young-Min
name: Park, Kyu Nam
name: Choi, Seung Pill
name: Kim, Gi Woon
name: Jeung, Kyung Woon
name: Jang, Tae Chang
name: Park, Yoo Seok
name: Kyong, Yeon Young
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Is a table presenting a list of the contributing sites and their ethical approval bodies.
Additional file 1 of Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation
Creators: name: Turunen, Heidi
name: Jakob, Stephan M
name: Ruokonen, Esko
name: Kaukonen, Kirsi-Maija
name: Sarapohja, Toni
name: Apajasalo, Marjo
name: Takala, Jukka
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: List of the ethics committees that approved the clinical trial protocols.
Kahler quantization of H*(T2,R) and modular forms
Creators: name: Loran, Farhang
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Kahler quantization of H1(T2,R) is studied. It is shown that this theory corresponds to a fermionic sigma-model targeting a noncommutative space. By solving the complex-structure moduli independence conditions, the quantum background independent wave function is obtained. We study the transformation of the wave function under modular transformation. It is shown that the transformation rule is characteristic to the operator ordering. Similar results are obtained for Kahler quantization of H2(T,R).
description: 9 pages, 1 figure
title: Supporting mastery learning by adapting exercise sequences in English as a foreign language to working memory and learner performance
Creators: name: Xiong, Yao
name: Meurers, Detmar
name: Quixal, Martí
name: Gawrilow, Caterina
name: Rudzewitz, Björn
name: Heck, Tanja
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: First and Second Language Acquisition
subject: Teacher Education and Professional Development
subject: Linguistics
subject: FOS: Languages and literature
subject: Education
subject: Social and Behavioral Sciences
subject: Computational Linguistics
subject: Secondary Education and Teaching
subject: adaptive intelligent tutoring systems
subject: computer-assisted language learning
subject: educational technologies
subject: foreign language teaching and learning

description: Individual learners benefit from adaptive teaching in teacher- orchestrated instruction settings. Thus, adaptive teaching is more effective if carried out at the individual level and more practical when supported by technology (Valle Torre et al., 2023; van de Pol et al., 2015). This paper presents a study that assesses a newly developed activity sequencing module in an Intelligent Language Tutoring System (ITS) for English as a foreign language (EFL). Through this module learning sequences can be individualized based on momentary cognitive status (i.e., working memory), previous knowledge, and ongoing performance. A total of 25 secondary school classes (N-students = 440) used the system to practice four different language constructs commonly taught in 7th grade in EFL courses in Germany: present simple, contrast between simple past and present perfect, relative clauses, and conditionals. Initial analyses show that (a) students in the control condition completed their assigned work but not always reached mastery in the target learning goals, while (b) students in the intervention condition worked through paths of different lengths and nature to reach mastery in the target learning goals. A regression analysis underway with a pre-posttest study design will evaluate if there is a significant difference in terms of learning gain.
Multispin Coding Technique for Nonequilibrium Reweighting
Creators: name: Lee, Hwee Kuan
name: Okabe, Yutaka
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present the multispin coding for the nonequlibrium reweighting method of the Monte Carlo simulation, that was developed by the present authors. As an illustration, we treat the driven diffusive lattice gas model. We use the multispin coding technique both for the spin update and for the calculation of the histogram of incremental weights, which is needed in the calculation of nonequlibrium reweighting. All the operations are executed by the bitwise logical commands.
description: accepted for publication in Int. J. Mod. Phys. C
Reconstruction of Initial Beam Conditions at the Exit of the DARHT II Accelerator
Creators: name: Paul, Arthur C.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We consider a technique to determine the initial beam conditions of the DARHT II Accelerator by measuring the beam size under three different magnetic transport settings. This may be time gated to resolve the parameters as a function of time within the 2000 nsec pulse. This technique leads to three equations in three unknowns with solution giving the accelerator exit beam radius, tilt and emittance. We find that systematic errors cancel and so are not a problem in unfolding the initial beam conditions. Random uncorrelated shot to shot errors can be managed by one of three strategies: 1) make the transport system optically de-magnifying; 2) average over many individual shots; or 3) make the random uncorrelated shot to shot errors sufficiently small. The high power of the DARHT II beam requires that the beam transport system leading to a radius measuring apparatus be optically magnifying. This means that the shot to shot random errors must either be made small (less than about 1%) or that we average each of the three beam radius determinations over many individual shots.
description: 3 pages, 3 figures, LINAC2000 paper TUB10
Printed smart devices for anti-counterfeiting allowing precise identification with household equipment
Creators: name: Zhang, Junfang
name: Tan, Rong
name: Liu, Yuxin
name: Albino, Matteo
name: Zhang, Weinan
name: Stevens, Molly M.
name: Loeffler, Felix F.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electronic devices
subject: Surfaces, interfaces and thin films
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Counterfeiting has become a serious global problem, causing worldwide losses and disrupting the normal order of society. Physical unclonable functions are promising hardware-based cryptographic primitives, especially those generated by chemical processes showing a massive challenge-response pair space. However, current chemical-based physical unclonable function devices typically require complex fabrication processes or sophisticated characterization methods with only binary (bit) keys, limiting their practical applications and security properties. Here, we report a flexible laser printing method to synthesize unclonable electronics with high randomness, uniqueness, and repeatability. Hexadecimal resistive keys and binary optical keys can be obtained by the challenge with an ohmmeter and an optical microscope. These readout methods not only make the identification process available to general end users without professional expertise, but also guarantee device complexity and data capacity. An adopted open-source deep learning model guarantees precise identification with high reliability. The electrodes and connection wires are directly printed during laser writing, which allows electronics with different structures to be realized through free design. Meanwhile, the electronics exhibit excellent mechanical and thermal stability. The high physical unclonable function performance and the widely accessible readout methods, together with the flexibility and stability, make this synthesis strategy extremely attractive for practical applications.