cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Solvent-free beta-carotene nanoparticles for food fortification
Creators: name: Huynh, Phong Tien
Publisher: name: No Publisher Supplied
Year: 2012

description: Most nutraceutical compounds are poorly-water soluble. Their low solubility decreases the adsorption rate in living organisms leading to their low bioavailability. Utilization of nanoparticles is a promising way to improve the solubility of hydrophobic compounds. Nanoparticles increase the total surface area of the poorly-water soluble nutraceuticals making them more bioavailable.   Some traditional methods for decreasing particle size include pearl or jet milling, where particles are broken down through grinding or collisions under high pressure. These mechanical processes not only require high energy input but also raise a concern of milling media residues. The high pressure homogenizer approach applies implosion forces and collision of particles to generate nanosuspensions. This method requires microsuspensions as starting material and consumes high energy.   Among several emulsion-based techniques for preparing nanoparticles, solvent diffusion practice is a novel approach in which a poorly-water soluble compound is transferred into nanoemulsion droplets of a partially water-soluble organic solvent. The compound then crystallizes because the solvent diffuses out of the emulsion droplets. The key point of proposed emulsion-diffusion technology is that the phase transition occurs within an isolated nanoemulsion droplet.   The main purpose of this study is to develop a “green” and scalable method for preparing nanosuspensions of highly hydrophobic compounds. We use FDA GRAS ingredients to create nanoparticles of poorly-water soluble nutraceuticals.  β-carotene is selected as a model hydrophobic nutraceutical. Triacetin, a partially- water soluble triacetate compound, is used as the dispersed phase of nanoemulsions. The influence of surfactant, water concentration, and homogenization time on particle size and stability is investigated. The impact of surfactant on diffusion flux of triacetin is studied. Kolmogorov theory is applied to reveal the breakup mechanism of emulsion droplets under shear and predict their size. A mathematical model is built to discover the size of emulsion droplet during the formation of nanosuspensions. It is hoped that the this work will greatly advance the manufacture of nanoparticles of poorly-water soluble nutraceuticals
Elachertus fenestratus Nees
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 21. Elachertus fenestratus Nees
Material examined. 1 ♀, Israel, Mt. Carmel, Nahal Oren, 14.iv.2006 (A. Freidberg); 2 ♂, Ma’agan Mikha’el, M.T., 26.iii.2009 (W. Kuslitzky); 1 ♀, Ramat haSharon, M.T., 3.x.2006 (D. Gerling); 1 ♂, Tel Aviv, M.T., 10.v.2007 (W. Kuslitzky); 1 ♀, Tel Aviv, M.T., 23.v.2007 (W. Kuslitzky).
Hosts. Ectoparasitoid of Coleophora limosipennella Duponchel (Lepidoptera: Coleophoridae) (Bouček & Askew 1968).
Distribution. Israel *; Palearctic (Bouček & Askew 1968; Zhu & Huang, 2001), Nearctic (Peck 1963) and Neotropic (De Santis 1989) ecorealms.
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 8, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Hartiellinae Danielopol 1971
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae

description: Subfamily Hartiellinae Danielopol, 1971
1971a Hartiellini nov.—Danielopol: 191, 201–202 (D, R, T).
1971b Sphaeromicolini.—Danielopol: 190 [in part] (D).
1974 Hartiellinae Danielopol, 1971.—Hart & Hart: ix, 9, 14, 16, 17, 168 (C, D, H, K, T).
1975 Hartiellinae Danielopol, 1971.—Hobbs: 280 (C, D, H).
1975 Hartiellinae Hart & Hart, 1974.—Hart & Hart: 1, 63 [erroneous authority] (C, D, H).
1977b Hartiellini.—Danielopol: 22, 23, 35, Fig. 1 (C, D, R).
1977b Hartiellinae.—Danielopol: 22 (C).
1977 Hartiellinae Danielopol, 1971.—Hobbs & Peters: 16 (C).
1978 Hartiellinae.—Hart: 727 (K).
1985 Hartiellinae.—Danielopol & Hart: 54, 55, 57, 62, Fig. 1 (C, D).
2012 Hartiellinae.—Mestre, Monrós & Mesquita-Joanes: 45 (C).
2014a Hartiellinae Danielopol, 1971.—Mestre, Monrós & Mesquita-Joanes: 928, 931, 950 (C, D).
2014b Hartiellinae.—Mestre et al.: 235 (C, R).
Remarks: Tribe Hartiellini, established by Danielopol (1971a) was elevated to subfamily in Hart & Hart (1974: 168).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 97, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Surface Science Studies of CVD and ALD Processes for Ru Depo
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The following is a proposal for the investigation of the fundamental surface chemistry of ruthenium precursors as it relates to atomic layer deposition (ALD) processes for the growth of thin films on solid surfaces. ALD is poised as one of the most promising technologies for the deposition of such films in microelectronic applications. The main issue here is the difficulty to continue to use the current physical vapor deposition (PVD) techniques as the size of the microelectronic components is reduced further and the complexity of the circuits add roughness to the surfaces in need of coating. ALD, being a chemical technique, provides to ideal properties to replace PVD: (1) it is isotropic, and can therefore handle complex topographies, and (2) by separating the overall chemistry into two half-cycles, it offers great control over the thickness of the films, to the monolayer. On the other hand, ALD is still in its early stages, and present some problems not yet solved, in particular its tendency to deposit impurities from side reactions when activating the chemical precursors used. A better understanding of the surface chemistry involved is required to minimize those effects and allow for ALD to become the next deposition technique of choice for future microelectronic manufacturing processes. Our work will help address issues currently limiting the implementation of ALD technology in the microelectronics industry.
Modeling insertion of transmembrane beta-barrels for designing outer membrane proteins
Creators: name: Hsieh, Daniel
Publisher: name: No Publisher Supplied
Year: 2012

description: Outer membrane proteins (OMPs) perform a range of important functions in the cell biology of Gram-negative bacteria, mitochondria and chloroplasts. These functions include biogenesis, virulence, signal transduction, nutrient transport and apoptosis. In contrast to their inner membrane counterparts, OMPs have been more difficult to study due to the relative paucity of crystal structures.      Although outer membrane proteins have been characterized and studied extensively by various structural and biophysical methods, our understanding of their folding, insertion and oligomerization is far behind that of inner membrane proteins. The goal of this study is to elucidate the folding and insertion mechanism of these transmembrane β-barrel proteins (TMBs) and ultimately to provide guidelines for computationally designing OMP sequences that fold and insert efficiently. Using a subset of amino acids from thirty-five outer membrane proteins from Gram-negative bacteria and mitochondria, a propensity vs depth in membrane profile for each residue was derived. Although results indicate similar trends between amino acids of inner and outer membrane proteins, there are also differences that can be explained by differences in factors such as environment, secondary structural preferences, and folding/insertion pathway.     The propensity profiles were converted into energies of insertion as a function of depth from the center of the membrane. This thesis explores the many ways of using the statistical potential to answer questions about OMP folding, insertion and oligomerization that could not have been framed due to the experimental limitations. We conclude with a discussion of ways to improve our potential, including the assumption of asymmetry of the lipid bilayer as well as incorporating homology model building.
High-throughput scanner for label-free IgG affinity assay
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Monoclonal antibodies are a class of molecules that are increasingly explored and developed as highly target-specific drugs or drug delivery vehicles against proteins and other macromolecules that are implicated in cancers and other diseases. The high specificity of monoclonal antibodies against their targets minimizes the scope of side effects or toxicity, when compared to small-molecule compounds as drugs. When a protein target elicits immunogenic response in a host, hundreds of antibodies against a handful of the epitopes on the protein are routinely produced, with different affinities, inhibition efficacy, and toxicity. Sorting these antibodies by affinity and by epitope is challenging and yet necessary when limited resources need to be focused on a few most promising candidates for further costly studies and development. To meet this challenge, we propose to combine the commercial capability of Epitomics in manufacturing a large variety of rabbit monoclonal antibodies with a proprietary RabMab technology and the optical technology developed at University of California, Davis for parallel detection of hundreds to thousands of antibody-antigen binding reactions. In particular, we propose to develop and apply a special optical detector to ranking and sorting hundreds of rabbit monoclonal antibodies against three cancer therapeutic targets, Her2, Her3, and Dkk1 by affinity and by epitopes on these protein targets. The information will be used in downstream initial drug development.
The heart of the city
Creators: name: Hayes, Christopher
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation uses New York City’s July 1964 rebellions in Central Harlem and Bedford-Stuyvesant to explore issues of civil rights, liberalism, policing and electoral politics in New York City between 1945 and 1966. The city’s rebellions, the first of the 1960s urban uprisings that would come to define the decade, had widespread repercussions and shaped political campaigns at the local, state and national levels. Looking both backward and forward from the rebellions, I examine the causes many observers gave for the rebellions as well as what outcomes the uprisings had. Using archival records, government documents, newspapers and correspondence between activists and city officials, I look at the social and economic conditions in which black New Yorkers lived during the postwar period, the various ways in which black citizens and their white allies tried to remedy pervasive segregation and its deleterious effects, and the results of those attempts at reform. In providing a previously unavailable narrative of the nearly weeklong July rebellions, I show the ways in which the city’s black citizens expressed their frustrations with city officials, the police and local black leaders and how each group responded. By 1964, many black New Yorkers were frustrated with the glacial pace of civil rights progress in the city and were searching for alternatives to integrationist movements, leading to activism and sentiments that would soon be labeled as Black Power. The civilian review board referendum of 1966 represents the last stand of the city’s interracial liberal civil rights coalition. Exploring the campaigns for and against the board helps us to see the growth of white political conservatism, the previously unknown political power of the police, the decline of support for liberalism among black and white populations and the increase in racial hostility in New York City after 1966. Through looking at civil rights in the city during the postwar period, we can see the limits of liberalism. New York was considered one of the most liberal cities in the country during the postwar period, but its black citizens still faced the same issues as their counterparts in Chicago and Detroit.
Modeling correlated mutations in computational biology using log-linear analysis and graph-theoretic probabilistic inference methods
Creators: name: Haq, Omar
Publisher: name: No Publisher Supplied
Year: 2012

description: Point mutations are random events but selection for protein stability and function fixes specific combinations of amino acid mutations in the protein population. Many mutations are not independent but are found to be strongly correlated, the signal for which is present in multiple sequence alignment data. Using HIV Protease as a model system, this work bridges the gap between the analysis of protein sequences using statistical techniques developed by the physics and computer science communities, and the biophysical modeling of protein energetics. Using information theoretic methods together with a coarse-grained (Generalized Born) energy model we have analyzed the contribution of electrostatic interactions to protein stability among mutated residues of HIV-1 protease  based on models derived from a large database of sequences which have acquired drug resistance. In the course of this work we have constructed a mean field model at the level of pair correlations (Bethe approximation) to predict the probabilities of observing mutated sequences using the HIV sequence database to parameterize the model.
Reforming charm city
Creators: name: Halpin, Dennis P.
Publisher: name: No Publisher Supplied
Year: 2012

description: “Reforming Charm City: Grassroots Activism and the Making of Modern Baltimore, 1877-1920” uses Baltimore as a case study to explore the ways that race, class, and gender shaped the urban experience in the nineteenth and twentieth century United States.  This dissertation examines the Progressive Era from the bottom up. Far from being quiescent subjects of reform, working people built the foundations for equality between 1877 and 1920.  Their efforts complicate our understandings of an era too often depicted solely as the triumph of middle-class and elite conceptions of order. Using court records, memoirs, vice reports, newspapers, and government documents this project examines the multiple ways in which Baltimore’s disenfranchised residents challenged entrenched powers, altered political debates, helped establish policies on vice, and reshaped the city’s residential landscape. In so doing, it uncovers a largely neglected history of African-American reformers who laid the foundation for the twentieth century civil rights movement and defeated the nation’s first housing segregation ordinance.  Similarly, it documents how workers and other non-elites mounted campaigns to end political corruption and economic exploitation, and how women from all of these groups addressed a range of urban woes.
Secreted proteins as detection markers for citrus diseases
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The phloem-limited and insect vector-transmitted citrus stubborn disease, caused by a bacterial pathogen Spiroplsama citri, has resulted in constant yield losses and quality reductions to the one-billion dollar California citrus industry. Depending on the citrus varieties, the reduction on the yields from this disease can be up to 100%. The currently available diagnostic methods are either labor-intensive or inaccurate due to the uneven distribution and the low titer of the pathogen in the infected trees. Especially, no economic and reliable diagnostic tool is available to support large scale testing for citrus certification programs, such as the Citrus Clonal Protection Program (CCPP). This gap in our current diagnostic capacity for citrus stubborn disease greatly impairs the fundamental control method for the disease, i.e., the use of disease-tested propagative materials. The main goal of this project is to develop an immunoassay-based diagnostic method for citrus stubborn disease by detecting abundant proteins secreted from Spiroplasma citri into citrus phloem. Secreted proteins from bacterial pathogens significantly contribute to virulence. More importantly, secreted proteins may not be restricted to the infection sites and can be relatively abundant, which enable robust detection of the disease. In this proposed research, we will first identify the secreted proteins from Spiroplasma citri using proteomic and genomic approaches. Suitable proteins will then be evaluated as detection markers. This project will provide a new and modern diagnostic method that improves the overall scheme of citrus disease diagnostics. This is essential for the safe release of new varieties to the industry and the maintenance of stubborn-free germplasm sources, which are absolutely required for a sustainable and viable California citrus industry. Furthermore, the proposed research will advance our understanding on the molecular interactions between citrus and bacterial pathogens that lead to citrus stubborn disease. This novel knowledge will be extremely important for the development of control strategies for citrus stubborn disease as well as other ecologically-related, graft-transmissible and phloem-limited citrus diseases, such as the citrus greening (Huanglongbing or HLB).
Modeling longitudinal data with mixed dropout mechanisms using extended pattern mixture model
Creators: name: Gong, Jing
Publisher: name: No Publisher Supplied
Year: 2012

description: In physical and mental health research areas, longitudinal studies are popular tool for addressing outcome changes over time within and between individuals. However, monotone-type missing data caused by dropout is unavoidable in many longitudinal studies and may lead to biased inference and incorrect conclusions if the nature of dropout is ignored. The dropout process may cause three types missingness: Missing Completely at Random (MCAR), Missing at Random (MAR), and Missing Not at Random (MNAR). Most of existed statistical methods have treated the entire dropout the same, although this assumption may not be true in practice. For a real longitudinal study, based on observed dropout reasons, it may be more realistic to assume the nature of missingness to be a mixture of MCAR, MAR and MNAR.   In this thesis, two approaches are proposed to deal the mixed nature of dropout due to different longitudinal dataset’s pattern and assumptions, and both of them are based on Pattern Mixture Model. If the outcome of interest can be assumed to follow a linear trend over time and the detailed dropout reasons for each subject are unknown, EM algorithm method will be added to Pattern Mixture Model to reflect a mixture of missing natures. If the outcome of interest is not linear with respect time and the detailed reasons for each dropout are known, available-case missing value restriction and non-future-dependent missing value restriction will be used within Pattern Mixture Model to identify the distribution of unknown measurements caused by different dropout reasons. Multiple imputation method will be combined to impute multiple complete datasets to reflect the uncertainty caused by missing values.
Elachertus inunctus Nees
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 22. Elachertus inunctus Nees
Material examined. 1 ♀, Israel, Ma’agan Mikha’el, M.T., i.2009 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., 29.ii.2009 (W. Kuslitzky).
Hosts. Ectoparasitoid of Elachistidae and Gracillariidae (Lepidoptera) (Askew & Shaw 1974). Distribution. Israel *; Palearctic (Bouček & Askew 1968; Zhu & Huang, 2001; Yefremova 2002; Hedqvist 2003).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 8, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Axina ordinis Opitz 2020, new species
Creators: name: Opitz, Weston
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cleridae
Axina
Axina ordinis

description: Axina ordinis Opitz, new species
Figures 56, 72, 117.
Type material. Holotype. Female. Type locality: Trindade (Goyaz) Ch. Pujol (Brazil) (MNHN).
Diagnosis. This is a slender species. The holotype is four times longer than broad. This characteristic will distinguish the holotype specimen from specimens of other Axina species with a partial black pronotum midline.
Description. Size. Length 12.0 mm; width 3.0 mm. Form. As in Fig. 117. Color. Cranium, thorax, and legs castaneous, except, pronotum with narrow black line that extends from mesoscutellum to discal indentation; elytra bicolorous, mostly flavotestaceous, epipleural margin broadly dark brown, dark brown region projects laterally to occupy elytral base, elytron middle, and elytral preapical region. Head. Cranium finely punctate, frons about as wide as length of antennal pedicel; EW/FW 45/10. Thorax. Pronotum finely punctate, with 2 paralateral spheroid tumescences, disc narrowly concave near middle; PW/PL 110/140; elytra, asetiferous punctures substriate, punctures extend posteriorly to elytral 3/4, width of interstitial spaces variable; EL/EW 410/90. Abdomen. Female pygidium trilobed distally (Fig. 56).
Distribution (for map see Fig. 72). This species is known from Brazil.
Etymology. The specific epithet, ordinis, is a Latin name with a meaning of “line”. I refer to the narrow black line at the base of the pronotum disc.
description: Published as part of Opitz, Weston, 2020, Taxonomic revision of the Western Hemisphere checkered beetle genus Axina Kirby (Coleoptera: Cleridae: Clerinae), pp. 1-70 in Insecta Mundi 2020 (793) on page 36, DOI: 10.5281/zenodo.4564947
Hartiella Danielopol 1971
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Hartiella

description: ** Hartiella Danielopol, 1971
1938 Sphaeromicola Paris. —Hubault: 11, 12, 23 [all in part] (C, T).
1942b Sphaeromicola.—Hoff: 63, 64, 65 [all in part] (C, T).
1948b Sphaeromicola.—Remy: 1, 3, 4 [in part] (C, R).
1962 Sphaeromicola Paris, 1916.—Hart: 121, 122, 123, 124, 125, 139, all in part (C, D, K, T).
1968 Sphaeromicola.—Roelofs: 40 (E).
1970 Hartiella n. g.—Danielopol: 148, nomen nudum (C).
1971a Hartiella.—Danielopol: 190, 201 (T).
1971b Sphaeromicola.—Danielopol: 187 [in part] (D).
1974 Hartiella Danielopol, 1971.—Hart & Hart: ix, 163, 168, Fig. 49 (C, D, H, K, T).
1974 Hartiella Danielopol, 1971.—Hartmann & Puri: 50 (C).
1975 Hartiella Danielopol, 1971.—Hart & Hart: 63 (C, D, H).
1977b Hartiella.—Danielopol: 22 (R).
1985 Hartiella.—Danielopol & Hart: 57 (C).
Remarks: A formal diagnosis for the genus Hartiella was not given in Danielopol (1971a), but as the tribe Hartiellini, now subfamily Hartiellinae, is monotypic, the diagnosis is assumed to be the same for the genus as for the higher rank.
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 97, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
A-HYPE River Input Data
Creators: Tahya Weiss-Gibbons
Publisher: name: University of Alberta Library
Year: 2023

The input runoff data used to force a ANHA4 NEMO simulation. The raw river data is provided from A-HYPE hydrological model for the Arctic and Hudson Bay, with Dai and Trenberth (2009) for the rest of the ANHA4 domain. This data has been processed to distribute large inflow points along the coastline, in a manner consistent with the ANHA4 grid.
studies on food and the body
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This MRP proposal to extend a currently funded MRG will create an intellectual home for scholars who work at the nexus of cultural and social studies of food, nutrition, and the body in the University of California. Its activities will consist of colloquia for works in progress, public conferences and events, graduate mentoring, grant collaborations, and a planned joint graduate program. Its members, first brought together as part of the 2006 UCHRI residential research group “Eating Cultures: Race and Food,” draw from the strengths of three campuses in particular, where small clusters of food scholars already exist and meet regularly. At UCSC, the “agrifood research group” has met informally for several years to share research, hold workshops, and host occasional visitors. With individual faculty strengths in the social sciences (Sociology, Anthropology, Environmental Studies, and Community Studies), student interest in alternative food systems, social justice, and the presence of the campus farm and garden, the focus has tended towards agroecology, sustainable food systems, and food security, although there is growing interest to widen the scope of concern—particularly by involving more humanities scholars in the conversation. At UC Davis, food scholars reside in the social sciences and humanities, specifically in the programs/departments of American studies, Women and Gender studies, English, Theater, and History with one recent cross appointment between American Studies and Food Science and Technology. These scholars employ diverse methodologies including historical inquiry, literary criticism, ethnographic analysis, and critical theory. At UC Berkeley, UCLA, and UC Santa Barbara, scholars in history offer breadth in scholarly considerations of food and drink, particularly in Europe. The collective expertise bridges otherwise isolated scholars in agricultural and food systems and humanities and cultural studies. The concentration of MRP members located in Northern California allows for regular fruitful collaborations without excessive travel expenditures. Its goals are to address critical issues in California, to recruit and train exceptional graduate students with cross-disciplinary expertise, to produce broad-minded work on food, health, and the body within the university that reaches an audience within and beyond the university, to engage with regional food and wine industries and the general public on issues of joint concern, and to facilitate joint grant proposals within the humanities, social sciences, and through collaborations with the sciences that address concerns of the body and food from an interdisciplinary perspective.
Antiplasmodial and phytochemical investigation of traditionally used antimalarial plants of the United States
Creators: name: Graziose, Rocky Thomas
Publisher: name: No Publisher Supplied
Year: 2012

description: Malaria is a devastating parasitic disease that causes over 200 million infections and 600,000 human deaths a year. Increased drug resistance to currently used antimalarial therapies signifies a need to discover and develop novel treatments. Although not a present day issue, malaria was once a major concern in the United States and people often utilized local plant species to treat the disease. Since the eradication of malaria from the U.S. in the 1950’s, many herbal remedies have been forgotten and survive only in written records. Such historically reported plants may hold potentially potent and novel antimalarial compounds.  This research project was designed to 1) Identify promising plant species of the United States that have been used to treat malaria; 2) Collect, extract and test the in vitro antiplasmodial activity of the selected  species; 3) Isolate, identify and characterize the phytochemicals within those plants that are responsible for the observed activity.  This work resulted in the in vitro antiplasmodial screening of 243 extracts from 46 plant species representing 28 angiosperm families. Six species were selected for bioassay guided fractionation to isolate the bioactive constituents (of which four are described in detail here). Forty two chemical compounds displaying antiplasmodial activity were isolated in pure form, of which 9 novel compounds were newly described. The IC50 values of the compounds ranged from 0.11 µM to over 100 µM. All isolated compounds were also tested for cytotoxicity and several for their in vitro ability to inhibit Leishmania tarentolae as a proxy for antileishmanial activity.   This work provides pharmacological and phytochemical support for the ethnobotanical use of plant species traditionally used to treat malaria in the United States. It also adds to the number and diversity of plant derived antiplasmodial compounds.  The rich ethnobotanical history of the United States has been overshadowed as reliance on modern medicine has become the standard. However, as evidenced by this dissertation, traditional remedies, even those that are no longer used, continue to serve as a potentially important source lead for modern drug discovery.
Next Generation Electrochemical Supercapacitors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This proposal aims to establish a world-class program of research and education in the area of capacitive energy storage. Economically viable large-scale energy storage systems are key to widespread adoption of renewable energy technologies (solar, wind) due to the need to match the intermittent nature of these energy sources with the user demand. The proposed MRPI will benefit the State of California by facilitating wider adoption of renewable energy production, increase UC’s competitiveness in the important area of clean energy technologies and lead to future extramural funding. We will focus on developing novel materials and architectures for electrochemical capacitors (ECs), also called supercapacitors, which store energy by fast and reversible surface (or near-surface) redox reactions. Supercapacitors exist over a wide range of energy and power densities that bridge the gap between high energy density and high power density (i.e., between batteries and traditional capacitors). With ECs, there is the prospect of maintaining the high energy density of batteries without compromising the high power density of capacitors, a combination offering extraordinary opportunities for energy production, storage and recovery. The proposed research program is a comprehensive one which combines experimental and computational components to achieve a fundamental understanding of charge storage processes in redox-based materials, specifically transition metal oxide systems. These materials are a particularly appealing target because with few exceptions, theoretical values of their specific capacitance are several times greater than experimentally achieved results. It is, therefore, a topic where improved fundamental understanding of pseudocapacitive materials can have a dramatic impact. Experimental studies will focus on creating pseudocapacitor materials with appropriate nanoporous architecture that has high active surface area and promotes the development of high conductivity pathways, thus facilitating high storage densities and fast charge transfer rates. First-principles calculations will complement these studies by elucidating the energies associated with the redox processes and thus help us to identify the most attractive materials systems which are capable of multi-electron redox and greater energy storage.
Elachertus pulcher Erdos
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 23. Elachertus pulcher (Erdős)
Material examined. 1 ♀, Israel, HaKefar, HaYaroq, 30.ix.1976, sweeping (D. Simon); 1 ♀, Tel Aviv, M.T., 15.xii.2006 (W. Kuslitzky); 2 ♀, Hefer Valley, 32°22’ N; 34°35’E, 31.vii. 2013, 13m suction (M. Kishenevsky). Hosts. Unknown.
Distribution. Israel *; Palearctic (Bouček & Askew 1968; Kalina 1989).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 9, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Impact of online word-of-mouth on Amazon ranks in selected product categories
Creators: name: Grinberg, Irina
Publisher: name: No Publisher Supplied
Year: 2012

description: In this thesis, I address a growing trend in how consumers obtain information prior to making their online purchasing decisions. Specifically, I investigate the relationship between online word-of-mouth (WOM; customer reviews and ratings) and sales, measured by Amazon.com “ranks”, for different product categories. I collect daily data from Amazon.com for twenty products in ten categories from December 8, 2011 to February 29, 2012 in an effort to capture changes in online WOM and how it impacts sales. I expand on the traditional metrics used to measure online WOM and mimic how consumers use review information on Amazon.com to make their purchases there.    As part of my approach, I take into account the endogenous nature of reviews via instrumental variables. Results of this thesis show that in the Electronics category (1) the number of reviews significantly impact its rank, (2) a two-star rating (compared to a one-star rating) versus a four-star rating (compared to a one-star rating) has a greater impact on its rank, (3) Amazon’s Facebook.com “Likes” feature significantly impacts rank in Books, Electronics and Music, and (4) the impact of online WOM is significant for experience goods, but not for search goods.    My findings suggest that online WOM metrics impact consumer purchase decisions through awareness and persuasion. Moreover, it underlines the emerging role of social media in sales outcomes. From a managerial standpoint, these findings suggest that businesses should use ratings, reviews, and social media to build awareness about their products and influence purchase decisions. Future research in online WOM and sales (or rank) outcomes for product categories should control for advertising and product heterogeneity within categories, as well as incorporate social media metrics, review text and length.
Hartiella dudichi Danielopol 1971
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Hartiella
Hartiella dudichi

description: † * Hartiella dudichi (Klie, 1938) Danielopol, 1971
1938 Sphaeromicola dudichi n. sp. —Klie: 317, 318–322, Figs. 1 –11 (D, H, R, T).
1938 Sphaeromicola dudichi.—Hubault: 18, 19 (R).
1942b Sphaeromicola dudichi Klie 1938.—Hoff: 66 (C, D, H).
1946 S. dudichi Klie. —Remy: 8 [also as Sphaeromicola Dudichi, lapsus calami] (R).
1948b S. Dudichi Klie. —Remy: 1, 3 (D, E, H).
1948a Sphaeromicola Dudichi Klie. —Remy: 129, 132, lapsus calami (C, R).
1951 Sphaeromicola dudichi Klie. —Kesling: 92 (D, E, H).
1951 Sphaeromicola dudichi Klie. — Rioja: 169, 170, 171, 178, 179 (R).
1960 Sphaeromicola Dudichi Klie. —Delmare-Deboutteville: 660, lapsus calami (C, D, H).
1962 Sphaeromicola dudichi Klie. —Hart: 140 (C, D, T).
1964 Sph. dudichi.—Vandel: 303 (C, E).
1966a Sphaeromicola dudichi Klie, 1938.—Roelofs: 207–212, Figs. 1a–e, 2a–g (D, H, T).
1966b Sphaeromicola dudichi.—Roelofs: 151 (E, U).
1967 Sphaeromicola dudichi, Klie, 1938.—Hart, Nair & Hart: 1 (H).
1968 Sphaeromicola dudichi Klie, 1938.—Roelofs: 40–42, 44–51, Figs. 1 –16 (D, E, H).
1970 H. dudichi Klie (Sphaeromicola dudichi).—Danielopol: 148, new comb. but nomen nudum (R).
1971a Hartiella dudichi (Klie, 1938).—Danielopol: 190 (also as Sphaeromicola dudichi), 191–201, 202, 203, 204, 205, 206, Figs. 1A–E, 2A–G, 3A–M, 4, 5A–C, 6A–D, 7A–F, 8, new comb. and redescription (A, D, H, R, T).
1971b Sphaeromicola dudichi (Klie).—Danielopol: 181 (E).
1971 Sphaeromicola dudichi Klie (1938).—Hobbs Jr.: 6, 45, 53, 54 (C, K).
1974 Hartiella dudichi (Klie, 1938).—Hart & Hart: 2 [and as Sphaeromicola dudichi Klie (1938)], 168 [and as Sphaeromicola dudichi Klie (1938)], 220, 238, Pl. XLIV Figs. 8–11, Pl. LXII; figures erroneously listed as 7–10 on p. 168 (C, D, E, H, T).
1975 Hartiella dudichi (Klie, 1938).—Hart & Hart: 63–64 (C, D, H).
1977b Sph. dudichi.—Danielopol: 22 (C).
1985 Sphaeromicola dudichi.—Danielopol & Hart: 56, 57, 61, 62, 64. Fig. 4A (C, R, T).
2005 Sphaeromicola dudichi.—Smith & Kamiya: 217, 218 (E).
2014a Hartiella dudichi (Klie, 1938).—Mestre, Monrós & Mesquita-Joanes: 950 (C).
Remarks: Remy appears to have capitalized the initial letter of the species name when derived from a personal
name; although undoubtedly deliberate, this is treated as an error retrospectively.
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on pages 97-98, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Mass infection is not an option: we must do more to protect our young.
Creators: name: Gurdasani, Deepti
name: Drury, John
name: Greenhalgh, Trisha
name: Griffin, Stephen
name: Haque, Zubaida
name: Hyde, Zoë
name: Katzourakis, Aris
name: McKee, Martin
name: Michie, Susan
name: Pagel, Christina
name: Reicher, Stephen
name: Roberts, Alice
name: West, Robert
name: Yates, Christian
name: Ziauddeen, Hisham
Publisher: name: Elsevier BV
Year: 2021
Subjects: Child
Humans
COVID-19
COVID-19 Vaccines
Disease Transmission, Infectious
Health Policy
Pandemics
Patient Acceptance of Health Care
Public Health
SARS-CoV-2
United Kingdom

description: Funder: Medical Research Council
description: Funder: Wellcome Trust
Network for Experimental Research on Evolution
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: NERE supports collaboration, communication, and graduate education concerned with research on biological evolution among UC campuses. NERE also serves as a conduit for interactions between University of California scientists and the global scientific community. “Experimental Evolution,” an edited volume is to be published by the University of California Press this year, 2009. NERE has developed proposals for collaborations among UC campuses for the purposes of both research and graduate education, and plans to continue this aspect of its activities with an application for funding as an NSF-supported network. The Western Evolutionary Biologist of the Year Prize is awarded by NERE to an individual from the west of North America (including western Canada and Mexico) who has contributed significantly to the scientific study of biological evolution and/or its understanding by the general public. NERE hosts an annual meeting of evolutionary biologists in California, drawing from the evolution research community throughout the western part of North America: the Western Evolutionary Biology (WEB) meeting. NERE currently has eight member UC campuses, and will expand to the ninth general-purpose UC campus, at Davis, if its funding is renewed.
Maintaining a positive sense of self
Creators: name: Grysman, Azriel
Publisher: name: No Publisher Supplied
Year: 2012

description: Numerous lines of research have identified that individuals are motivated to remember past events in a way that supports a positive sense of self. Memories of negative events challenge a person’s positive sense of self by suggesting that stable, positive traits that a person considers a part of his or her sense of self may not accurately describe that person. Five possible contributors to the degree to which people find an autobiographical memory challenging to the positive sense of self were identified: when the event occurred, the perspective with which the event is remembered, the person’s age, the person’s gender, and how meaningful the memory was. Participants were asked to identify a positive trait that describes them, and then to write a narrative of an event in which they did not act according to the selected trait. Each participant reported one event, either from the past year or from more than two years ago, and either from the first- or third-person perspective. After reporting the memory, participants completed a brief questionnaire, and responded to three ethical dilemmas (two hypothetical, one actual) that were used to measure participants’ tendency to engage in self-enhancement behavior after reporting the memories. Results found significant differences between emerging adults (age 18-29) and older adults (age 30 and above), and between men and women in the older adult group on numerous measures. Additionally, reported meaning and narrative indicators, such as emotion word use and reported harm to others, predicted performance on self-enhancement measures in both age groups. Time and perspective effects were more equivocal, but these two variables influenced responses, especially through interactions with participant variables (time and gender). Results suggest that threats to a positive sense of self can be alleviated by self-enhancement behavior in unrelated domains. Furthermore, results encourage the practice of analyzing memory narrative content to gain a deeper understanding of the impact of recalling significant events. Finally, results support the practice of considering adult development, both regarding changes in the sense of self and regarding influences of gender at different ages as a variable that shapes the content of autobiographical memories.
Broadband Full-Duplex Radio
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We will build a prototype broadband full-duplex radio which can send and receive data on the same frequency at the same time over a broad bandwidth. Such a radio will increase wireless communication data rates by twofold with any given spectrum allocation and overcome the limitations of current wireless networks based on half-duplex radios. We will use commercially available tools and components to build the prototype. The ingenuity of this project is a novel system-level integration of radio frequency devices and digital signal processing technologies.
Salt solid dispersions
Creators: name: Ghosh, Anasuya A.
Publisher: name: No Publisher Supplied
Year: 2012

description: Improving oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Pharmaceutical salt formation is a widely accepted approach to improve dissolution rate of poorly water-soluble ionic drugs. Nevertheless, the salt formation process is often empirical and may not always lead to desired end product profile. Alternatively, pH-modifiers have been used as formulation components for such compounds. The purpose of this study is to explore the synergies between pH modulating ability offered by a salt form and the dissolution enhancement offered by an amorphous solid dispersion. The hypothesis of this study is that for a weakly basic drug, its solid dispersion with a hydrophilic polymer and a salt-forming acidic counterion should provide dissolution enhancement similar to that of a solid dispersion of its salt. Secondly, for a weakly basic drug if a salt form with a selected counterion cannot be synthesized, then solid dispersion of the drug, the non-salt forming counterion and a hydrophilic polymer could also provide adequate dissolution enhancement. In the present investigation the dissolution enhancement of Cinnarizine, a weakly basic drug, is studied from its solid dispersions containing acidic counterions (organic acids) that have varying ability to form cinnarizine salts. The effect of adding ionic polymers as pH-modifiers is also investigated. Solid dispersions were prepared using melt extrusion technology. Molecular interactions between relevant functional groups of drug and pH-modifiers and the possibility of in situ salt formation during the melt extrusion process were explored.  The results of this study systematically offer the benefits of adding acidic counterions during melt extrusion, should a classical salt formation technique fail. A predictive computational model was used to estimate human in vivo plasma profiles by using in vitro dissolution of the developed solid dispersions and the marketed product.
Proof of Concept of a Novel Transcatheter Aortic Valve
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Transcatheter aortic valves (TAVs) are valves that are mounted on a stent, crimped to fit within a delivery catheter and then deployed within a patient with severe aortic stenosis(AS). These devices can be implanted minimally invasively via a small anterior thoracotomy or through the vasculature, i.e. femoral, subclavian artery. TAVs have revolutionized the treatment of severe AS patients that were previously inoperable as well as those of high surgical risk and TAV implantation (TAVI) has become the new paradigm in management of such patients. We became interested originally in developing a novel TAV to treat patients with prior bioprostheses that failed where the small size of these bioprostheses negatively impacts the hemodynamics of current TAVs. During the course of our development of such a supravalvular TAV, we developed additional IP that would be valuable in future iterations of TAVs. Our TAV has capabilities that current TAVs do not have--it is able to work in small annulus patients (small females), small sized bioprostheses, it is adjustable in height for patient specific conditions, it is replaceable in the future when the TAV fails, and it yields optimal hemodynamics. We submitted a patent through UCSF and have published in vitro data on our valve, but require significant funding to perform proof of concept tests in vivo. This grant would provide such funding to allow us to get to the next step of in vivo validation.
Energy efficiency indicators for the U.S. economy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The energy supply system has been the focus of most investigation and, as a result, we a have detailed understanding of where the nation's energy comes from. However, the same level of detail and accuracy does not exist on the demand side of the energy equation. We will undertake a detailed study of energy consumption on the demand side in order to provide the scientific and technical basis for sound energy efficiency policies. The goals of this study are to define useful metrics of energy efficiency for the most important end-use technologies and to accurately quantify the energy efficiency of end use.