cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Gli Epicurei romani sulla medicina: Senocle, Alessandro, Zopiro e Lucrezio
Creators: name: Piergiacomi, Enrico
Publisher: name: Ciceroniana on line
Year: 2019

description: Il saggio ricostruisce il pensiero di quattro Epicurei romani sulla medicina: Senocle di Delfi, Alessandro e Zopiro, che figurano nei libri 2-3 delle Questioni conviviali di Plutarco, e Lucrezio. La tesi generale che si sostiene è che questi personaggi hanno in comune il fatto di essere esperti conoscitori di medicina e, nello stesso tempo, filosofi che usano questo sapere con il fine etico di condurre gli esseri umani alla felicità e alla salute. Senocle ricorre forse alla dottrina medica di Asclepiade di Bitinia per spiegare il fenomeno dell’appetito e indirizzare alla sazietà. Alessandro guarda forse alla medicina per razionalizzare e confutare il comando orfico-pitagorico di astenersi dalle fave. Zopiro e Lucrezio presentano, infine, la riflessione di Epicuro sui piaceri sessuali, invitando a coltivarli con temperanza e una prassi igienica. The paper reconstructs the thought of four Roman Epicureans on the medicine: Xenocles of Delphi, Alexander, Zopyrus, who appear in books 2 and 3 of Plutarch’s Table Talk, and Lucretius. I argue that these characters are not only experts in medicine, but also share the common aim of making ethical use of this knowledge to lead humans towards happiness and good health. In turn, I explore the possibility that Xenocles draws on the medical doctrines of Asclepiades of Bithynia in order both to explain appetite and to exhort us to seek satiety; that Alexander uses medicine to explain and then reject the Orphic-Pythagorean injunction to abstain from beans; finally, that Zopyrus and Lucretius give an account of Epicurus’ reflection on sexual pleasure with the goal of encouraging the youth to seek it with moderation and with an hygienic regime.
description: Ciceroniana on line, V. 3 N. 1 (2019)
Time-resolved spectroscopy in time dependent density functional theory: An exact condition
Creators: name: Fuks, Johanna I.
name: Luo, Kai
name: Sandoval, Ernesto D.
name: Maitra, Neepa T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A fundamental property of a quantum system driven by an external field is that when the field is turned off the positions of its response frequencies are independent of the time at which the field is turned off. We show that this leads to an exact condition for the exchange-correlation potential of time-dependent density functional theory. The Kohn-Sham potential typically continues to evolve after the field is turned off, which leads to time-dependence in the response frequencies of the Kohn-Sham response function. The exchange-correlation kernel must cancel out this time-dependence. The condition is typically violated by approximations currently in use, as we demonstrate by several examples, which has severe consequences for their predictions of time-resolved spectroscopy.
description: 5 pages, 1 figure
Additional file 2: of MicroRNA suppression of stress-responsive NDRG2 during dexamethasone treatment in skeletal muscle cells
Creators: name: Mir, Bilal
name: Islam, Rabia
name: Kalanon, Ming
name: Russell, Aaron
name: Foletta, Victoria
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S2. MiRNA expression following combined miRNA mix transfection. MiRNA levels of (A) miR-23a (dark grey bars), (B) miR-23b, (light grey bars), and (C) miR-28 (white bars) following transfection of miRNA mix or negative control (NC) miRNA (black bars) at 48 h post transfection. Data are representative of two independent experiments with n = 4 per sample group. ***p
State Medical Board Policy and Opioid Prescribing: A Controlled Interrupted Time Series
Creators: name: Fulcher, N.
name: Ranapurwala, S.I.
name: Pence, B.W.
name: Marshall, S.W.
name: McCort, A.
name: Schiro, S.
name: DiPrete, B.L.
name: Ringwalt, C.L.
Publisher: name: Elsevier Inc.
Year: 2021

description: Introduction: In March 2016, the Centers for Disease Control and Prevention issued opioid prescribing guidelines for chronic noncancer pain. In response, in April 2016, the North Carolina Medical Board launched the Safe Opioid Prescribing Initiative, an investigative program intended to limit the overprescribing of opioids. This study focuses on the association of the Safe Opioid Prescribing Initiative with immediate and sustained changes in opioid prescribing among all patients who received opioid and opioid discontinuation and tapering among patients who received high-dose (>90 milligrams of morphine equivalents), long-term (>90 days) opioid therapy. Methods: Controlled and single interrupted time series analysis of opioid prescribing outcomes before and after the implementation of Safe Opioid Prescribing Initiative was conducted using deidentified data from the North Carolina Controlled Substances Reporting System from January 2010 through March 2017. Analysis was conducted in 2019–2020. Results: In an average study month, 513,717 patients, including patients who received 47,842 high-dose, long-term opioid therapy, received 660,912 opioid prescriptions at 1.3 prescriptions per patient. There was a 0.52% absolute decline (95% CI= −0.87, −0.19) in patients receiving opioid prescriptions in the month after Safe Opioid Prescribing Initiative implementation. Abrupt discontinuation, rapid tapering, and gradual tapering of opioids among patients who received high-dose, long-term opioid therapy increased by 1% (95% CI= −0.22, 2.23), 2.2% (95% CI=0.91, 3.47), and 1.3% (95% CI=0.96, 1.57), respectively, in the month after Safe Opioid Prescribing Initiative implementation. Conclusions: Although Safe Opioid Prescribing Initiative implementation was associated with an immediate decline in overall opioid prescribing, it was also associated with an unintended immediate increase in discontinuations and rapid tapering among patients who received high-dose, long-term opioid therapy. Better policy communication and prescriber education regarding opioid tapering best practices may help mitigate unintended consequences of statewide policies.
Is the Composite Fermion a Dirac Particle?
Creators: name: Son, Dam Thanh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose a particle-hole symmetric theory of the Fermi-liquid ground state of a half-filled Landau level. This theory should be applicable for a Dirac fermion in the magnetic field at charge neutrality, as well as for the $ν=\frac12$ quantum Hall ground state of nonrelativistic fermions in the limit of negligible inter-Landau-level mixing. We argue that when particle-hole symmetry is exact, the composite fermion is a massless Dirac fermion, characterized by a Berry phase of $π$ around the Fermi circle. We write down a tentative effective field theory of such a fermion and discuss the discrete symmetries, in particular, $\mathcal C\mathcal P$. The Dirac composite fermions interact through a gauge, but non-Chern-Simons, interaction. The particle-hole conjugate pair of Jain-sequence states at filling factors $\frac n{2n+1}$ and $\frac{n+1}{2n+1}$, which in the conventional composite fermion picture corresponds to integer quantum Hall states with different filling factors, $n$ and $n+1$, is now mapped to the same half-integer filling factor $n+\frac12$ of the Dirac composite fermion. The Pfaffian and anti-Pfaffian states are interpreted as $d$-wave Bardeen-Cooper-Schrieffer paired states of the Dirac fermion with orbital angular momentum of opposite signs, while $s$-wave pairing would give rise to a particle-hole symmetric non-Abelian gapped phase. When particle-hole symmetry is not exact, the Dirac fermion has a $\mathcal C\mathcal P$-breaking mass. The conventional fermionic Chern-Simons theory is shown to emerge in the nonrelativistic limit of the massive theory.
description: 13 pages; v2: added discussion of experimental signatures, Kohn's theorem; v3: typo fixed, published version
Additional file 1 of Diagnostic utility of brain MRI volumetry in comparing traumatic brain injury, Alzheimer disease and behavioral variant frontotemporal dementia
Creators: name: Raji, Cyrus A.
name: Meysami, Somayeh
name: Porter, Verna R.
name: Merrill, David A.
name: Mendez, Mario F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Supplementary Material 1
Aquitourism: Synergy between aquaculture and tourism
Creators: name: Basnayake, Ruwini
name: De Silva, Devarahandhi Achini Melda
Publisher: name: figshare
Year: 2022
Subjects: subject: 70499 Fisheries Sciences not elsewhere classified
subject: FOS: Agriculture, forestry and fisheries

description: Aquitourism, aquaculture related tourism in Sri Lanka
Cryptopone gilvagrande Branstetter & Longino 2022, New Species
Creators: name: Branstetter, Michael G.
name: Longino, John T.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Cryptopone
Cryptopone gilvagrande

description: Cryptopone gilvagrande, New Species (Figs. 6 [map],8,9,10) (Zoobank LSID: urn:lsid:zoobank.org:act: CD67CA6D-8BF0-470E-854C-EF12E2AC314B) Type material. Holotype worker: Guatemala, Baja Verapaz, Biotopo Quetzal, 15.21345, −90.21851 ± 50 m, 1725 m, 7 May 2009, cloud forest, ex sifted leaf litter (LLAMA Wa-B-02-2-05) [USNM, unique specimen identifier CASENT0614525]. Paratypes: same data as holotype [1 worker, UVGC, CASENT0614526; 1 worker, CAS, CASENT0640156; 1 worker, MCZC, CASENT0640157; 1 worker, UNAM, CASENT0640158; 1 worker, UCDC, CASENT0640159].
description: Published as part of Branstetter, Michael G. & Longino, John T., 2022, UCE Phylogenomics of New World Cryptopone (Hymenoptera: Formicidae) Elucidates Genus Boundaries, Species Boundaries, and the Vicariant History of a, pp. 1-23 in Insect Systematics and Diversity 6 (1) on page 16, DOI: 10.1093/isd/ixab031
Additional file 1: of Integration of HIV testing services into family planning services: a systematic review
Creators: name: Manjulaa Narasimhan
name: Yeh, Ping
name: Haberlen, Sabina
name: Warren, Charlotte
name: Kennedy, Caitlin
Publisher: name: Figshare
Year: 2019
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Translation of this article into French. (PDF 304 kb)
Safety and efficacy of Option B+ ART in Malawi: few severe maternal toxicity events or infant HIV infections among pregnant women initiating tenofovir/lamivudine/efavirenz
Creators: name: Jumbe, A.N.
name: DiPrete, B.L.
name: Harrington, B.J.
name: Hosseinipour, M.C.
name: Wallie, S.D.
name: Limarzi, L.
name: Ngongondo, M.
name: the S4 Study Team
name: Chagomerana, M.B.
Publisher: name: Blackwell Publishing Ltd
Year: 2019

description: Objectives: Malawi's Option B+ universal antiretroviral therapy (ART) program for pregnant and breastfeeding women does not include routine laboratory monitoring. We report safety outcomes of pregnant women who initiated ART through Option B+. Methods: We analysed 12-month data from an observational cohort study on Option B+ among women newly initiating tenofovir/lamivudine/efavirenz (TDF/3TC/EFV) at a government antenatal clinic in Lilongwe, Malawi. Proportions of women engaged in care, incidence of DAIDS grade ≥ 2 laboratory toxicity, grade ≥ 3 adverse events (AEs), viral suppression (<1000 copies/mL), birth outcomes and infant HIV infections are reported. Results: At ART initiation, participants (n = 299) had a median age of 26 years (IQR 22–30), median CD4 count of 352 cells/μl (IQR 231–520) and 94% were in WHO Stage 1. We noted 76 incident DAIDS Grade ≥ 2 laboratory results among 58 women, most commonly elevated liver function tests (n = 30 events) and low haemoglobin (n = 27). No women had elevated creatinine. Clinical AEs (n = 45) were predominantly infectious diseases and Grade 3. Five participants (2%) discontinued TDF/3TC/EFV due to virologic failure (3) or toxicity (2). Twelve months after ART initiation, most women were engaged in care (89%) and had HIV RNA < 1000 copies/ml (90%). 8% of pregnancies resulted in preterm birth, 9% were low birthweight (<2500 g), and 2% resulted in infant HIV infection at 6 weeks post-delivery. Conclusion: Most women remained on ART and were virally suppressed 12 months after starting Option B+. Few infants contracted HIV perinatally. While some women experienced adverse laboratory events, clinical symptom monitoring is likely reasonable.
Symmetry-protected topological order in magnetization plateau states of quantum spin chains
Creators: name: Takayoshi, Shintaro
name: Totsuka, Keisuke
name: Tanaka, Akihiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A symmetry-protected topologically ordered phase is a short-range entangled state, for which some imposed symmetry prohibits the adiabatic deformation into a trivial state which lacks entanglement. In this paper we argue that magnetization plateau states of one-dimensional antiferromagnets which satisfy the conditions $S-m\in$ odd integer, where $S$ is the spin quantum number and $m$ the magnetization per site, can be identified as symmetry-protected topological states if an inversion symmetry about the link center is present. This assertion is reached by mapping the antiferromagnet into a nonlinear sigma model type effective field theory containing a novel Berry phase term (a total derivative term) with a coefficient proportional to the quantity $S-m$, and then analyzing the topological structure of the ground state wave functional which is inherited from the latter term. A boson-vortex duality transformation is employed to examine the topological stability of the ground state in the absence/presence of a perturbation violating link-center inversion symmetry. Our prediction based on field theories is verified by means of a numerical study of the entanglement spectra of actual spin chains, which we find to exhibit twofold degeneracies when the aforementioned condition is met. We complete this study with a rigorous analysis using matrix product states.
description: 12 pages, 8 figures
Looking for Integrability on the Worldsheet of Confining Strings
Creators: name: Cooper, Patrick
name: Dubovsky, Sergei
name: Gorbenko, Victor
name: Mohsen, Ali
name: Storace, Stefano
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study restrictions on scattering amplitudes on the worldvolume of branes and strings (such as confining flux tubes in QCD) implied by the target space Poincare symmetry. We focus on exploring the conditions for the string worldsheet theory to be integrable. We prove that for a higher dimensional membrane the scattering amplitudes for the translational Goldstone modes ("branons") are double soft. At one-loop double softness is generically violated for the string worldsheet scattering as a consequence of collinear singularities. Violation of double softness implies in turn the breakdown of integrability. We prove that if branons are the only gapless degrees of freedom then the worldsheet integrability is compatible with target space Poincare symmetry only if the number of space-time dimensions is equal to D = 26 (a critical bosonic string), and for D = 3. We extend the analysis to include massless worldsheet fermions, resulting from spontaneous breakdown of the target space supersymmetry. We check that the tree-level integrability in this case is in one-to-one correspondence with the existence of a kappa-symmetric Green-Schwarz (GS) action. As a byproduct we show that at the leading order in the derivative expansion an N = 1 superstring without kappa-symmetry in D = 3,4,6,10 dimensions exhibits an accidental enhanced supersymmetry and is equivalent to a kappa-symmetric N = 2 GS superstring.
description: 28 pages, 9 figures, v2: typos corrected, references added, published version
Accurate algorithms for identifying the median ranking when dealing with weak and partial rankings under the Kemeny axiomatic approach
Creators: name: Amodio, Sonia
name: D'Ambrosio, Antonio
name: Siciliano, Roberta
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences
subject: G.3
subject: 62C99, 91B06, 90B50

description: Preference rankings virtually appear in all field of science (political sciences, behavioral sciences, machine learning, decision making and so on). The well-know social choice problem consists in trying to find a reasonable procedure to use the aggregate preferences expressed by subjects (usually called judges) to reach a collective decision. This problem turns out to be equivalent to the problem of estimating the consensus (central) ranking from data that is known to be a NP-hard Problem. Emond and Mason in 2002 proposed a branch and bound algorithm to calculate the consensus ranking given $n$ rankings expressed on $m$ objects. Depending on the complexity of the problem, there can be multiple solutions and then the consensus ranking may be not unique. We propose a new algorithm to find the consensus ranking that is equivalent to Emond and Mason's algorithm in terms of at least one of the solutions reached, but permits a really remarkable saving in computational time.
Measurement of depression treatment among patients receiving HIV primary care: Whither the truth?
Creators: name: Grelotti, D.J.
name: Pence, B.W.
name: DiPrete, B.L.
name: Gaynes, B.N.
Publisher: name: Elsevier B.V.
Year: 2018

description: Background: Prescription records, manual chart review, and patient self-report are each imperfect measures of depression treatment in HIV-infected adults. Methods: We compared antidepressant prescription records in an electronic data warehouse with antidepressant treatment and psychotherapy identified via manual chart review and self-report for patients at 6 academic HIV treatment centers. We examined concordance among these three sources, and used latent class analysis (LCA) to estimate sensitivity and specificity of each measure. Results: In our charts sample (n = 586), 59% had chart indication of “any depression treatment” and 46% had a warehouse prescription record. Antidepressant use was concordant between charts and data warehouse for 77% of the sample. In our self-report sample (n = 677), 52% reported any depression treatment and 43% had a warehouse prescription record. Self-report of antidepressant treatment was consistent with prescription records for 71% of the sample. LCA estimates of sensitivity and specificity for “any depression treatment” were 67% and 90% (warehouse), 87% and 75% (self-report), and 96% and 77% (chart). Limitations: There is no gold standard to measure depression treatment. Antidepressants may be prescribed to patients for conditions other than depression. The results may not be generalizable to patient populations in non-academic HIV clinics. Regarding LCA, dependence of errors may have led to overestimation of sensitivity and specificity. Conclusions: Prescription records were largely concordant with self-report and chart review, but there were discrepancies. Studies of depression in HIV-infected patients would benefit from using multiple measures of depression treatment or correcting for exposure misclassification.
Additional file 2: of CDKN2A copy number and p16 expression in malignant pleural mesothelioma in relation to asbestos exposure
Creators: name: Kettunen, Eeva
name: Savukoski, Sauli
name: Salmenkivi, Kaisa
name: Bรถhling, Tom
name: Vanhala, Esa
name: Kuosma, Eeva
name: Anttila, Sisko
name: Wolff, Henrik
Publisher: name: Figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure legend for Additional file 4. (PDF 1005 kb)
Additional file 3: of CDKN2A copy number and p16 expression in malignant pleural mesothelioma in relation to asbestos exposure
Creators: name: Kettunen, Eeva
name: Savukoski, Sauli
name: Salmenkivi, Kaisa
name: Bรถhling, Tom
name: Vanhala, Esa
name: Kuosma, Eeva
name: Anttila, Sisko
name: Wolff, Henrik
Publisher: name: Figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: A table - Relation of the CDKN2A copy number and p16 staining status in tumor cells of malignant pleural mesothelioma patients in general and with different asbestos-burden and in quality controls. (PDF 762 kb)
Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study
Creators: name: Osman, I.
name: Berwick, M.
name: InterMEL
name: Luo, L.
name: Rees, J.R.
name: Holmen, S.
name: Ko, J.
name: Conway, K.
name: Funchain, P.
name: Ernstoff, M.S.
name: Reynolds, A.Z.
name: Thomas, N.
name: Bosenberg, M.
name: Seshan, V.E.
name: Arora, A.
name: Boyce, T.
name: Ngo, P.
name: Schwartz, M.
name: Thompson, C.L.
name: Gorlov, I.
name: Fang, S.
name: Kuan, P.F.
name: Mann, G.
name: Orlow, I.
name: Hernando, E.
name: Nagore, E.
name: Wilmott, J.
name: Scolyer, R.
name: Bogner, P.
name: Busam, K.J.
name: Lee, T.K.
name: Gerstenblith, M.
name: Gould Rothberg, B.
name: Begg, C.B.
name: Cust, A.E.
name: Wiggins, C.
name: Brunsgaard, E.
name: Edmiston, S.N.
name: Saenger, Y.
name: Ollila, D.
name: Lezcano, C.
name: Amos, C.
name: Shen, R.
name: Lee, J.E.
name: Googe, P.B.
Publisher: name: John Wiley and Sons Inc
Year: 2022

description: It is unclear why some melanomas aggressively metastasize while others remain indolent. Available studies employing multi-omic profiling of melanomas are based on large primary or metastatic tumors. We examine the genomic landscape of early-stage melanomas diagnosed prior to the modern era of immunological treatments. Untreated cases with Stage II/III cutaneous melanoma were identified from institutions throughout the United States, Australia and Spain. FFPE tumor sections were profiled for mutation, methylation and microRNAs. Preliminary results from mutation profiling and clinical pathologic correlates show the distribution of four driver mutation sub-types: 31% BRAF; 18% NRAS; 21% NF1; 26% Triple Wild Type. BRAF mutant tumors had younger age at diagnosis, more associated nevi, more tumor infiltrating lymphocytes, and fewer thick tumors although at generally more advanced stage. NF1 mutant tumors were frequent on the head/neck in older patients with severe solar elastosis, thicker tumors but in earlier stages. Triple Wild Type tumors were predominantly male, frequently on the leg, with more perineural invasion. Mutations in TERT, TP53, CDKN2A and ARID2 were observed often, with TP53 mutations occurring particularly frequently in the NF1 sub-type. The InterMEL study will provide the most extensive multi-omic profiling of early-stage melanoma to date. Initial results demonstrate a nuanced understanding of the mutational and clinicopathological landscape of these early-stage tumors.
Сборник тезисов ХX Международной научной конференции «Лазаревские чтения» (5-6 октября 2022 года, г. Севастополь)
Creators: name: Филиал ФГБУ ВО "Московский государственный университет имени М.В. Ломоносова" в городе Севастополе
Publisher: name: Филиал ФГБУ ВО "Московский государственный университет имени М.В. Ломоносова" в городе Севастополе
Year: 2022

description: Сборник тезисов ХX Международной научной конференции «Лазаревские чтения» (5-6 октября 2022 года, г. Севастополь)
Additional file 1: of Switch from reference etanercept to SDZ ETN, an etanercept biosimilar, does not impact efficacy, safety, and immunogenicity of etanercept in patients with moderate-to-severe rheumatoid arthritis: 48-week results from the phase III, randomized, double-blind EQUIRA study
Creators: name: Jaworski, Janusz
name: Matucci-Cerinic, Marco
name: Schulze-Koops, Hendrik
name: Buch, Maya
name: Kucharz, Eugeniusz
name: Allanore, Yannick
name: Kavanaugh, Arthur
name: Young, Philip
name: Babic, Goran
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Protocol deviations defined as major by category. Table S2. HAQ-DI and FACIT-fatigue scores over 48â  weeks (TP2 per-protocol set). Table S3. TEAEs of special interest (TP2 safety set). Table S4. Summary of anti-drug antibodies up to week 48 using a 1% false-positive cut-point (Safety set). (DOCX 37 kb)
Comparison of the service life, life-cycle costs and assessment of hybrid and traditional reinforced concrete through a case study of bridge edge beams in Sweden
Creators: name: Chen, E.
name: Berrocal, Carlos G.
name: Löfgren, Ingemar
name: Lundgren, Karin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: The edge beams of reinforced concrete bridges with de-icing salts sprayed experience extensive corrosion damage. The average service life of edge beams needing replacement in Sweden has been reported as only 45 years, causing great economic loss to both owners and users. Hence, finding a durable solution for edge beams would benefit society. Hybrid reinforced concrete structures, produced by adding a low-to-moderate fibre content into traditional reinforced concrete, can effectively limit the service crack width and improve resistance to chloride-induced corrosion damage. In this paper, different alternatives of hybrid and traditional reinforced edge beams were designed for a case study. The service life of the alternatives was compared by conducting chloride diffusion calculations and by applying a corrosion-induced cracking model. The economic and environmental (indicated by greenhouse gas emissions) benefits of using hybrid reinforced edge beams were assessed by life-cycle cost analysis and life-cycle assessment. The results showed that the service life of edge beams made of hybrid reinforced concrete can be prolonged by over 58%, thereby enabling a significant reduction in the total life-cycle costs and annual total greenhouse gas emissions.
observational-study-on-clinical-features-treatment-and-outcome-of-covid-19-in-a-tertiary-care-centre-in-india--a-retrospective-case-series.
Creators: name: Rishav Mukherjee
Publisher: name: figshare
Year: 2020
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Till date, no proven therapy exists for treatment of SARS-coV-2 infections which has been declared a pandemic by WHO in March, 2020. OBJECTIVE: This study will attempt to explore the demographic prole and outcome in the patients receiving multidisciplinary, personalised approach including use of Broad Spectrum Antivirals - Ivermectin, anti-inammatory and antioxidants roles of Statins and N-acetyl-cysteine along with Standard of Care (SOC) in hospitalised COVID19 patients in a tertiary care centre. SETTING: Inpatient department (designated COVID ward) PARTICIPANTS: COVID-19 patients with laboratory conrmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the year 2020 between June 14- 28, 2020 Main outcome measures: The outcome of Interests are : a. Studying the demographic prole of COVID 19 cases b. Study the treatment outcomes in terms of death or discharge in patients receiving Ivermectin+N-acetyl-cysteine+Statin along with Standard of care.RESULTS: 148 patients were included in the study. All of them had conrmed COVID19 infection by the rtPCR method. Average age of the patients was 57.57 years ( Range = 17 - 88), 49% were male, 51% female. 81% of the patients had at least one or more comorbidities. Most common comorbidities included diabetes( 32%), Hypertension (27%),Ischaemic Heart Disease (8%). More comorbidities. The in hospital, Case Fatality Rate was 1.35 %. The remaining 146 were discharged from the facility after an average 12 days duration of stay. CONCLUSIONS:. Triple therapy with Ivermectin, N-acetyl-cysteine and Atorvastatin along with standard of care is safe and effective in SARS-coV-2 infection.
APLICATIVO PARA TOMADA DE DECISÕES FINANCEIRAS RELACIONADAS A RISCOS FISCAIS
Creators: name: Pinto, Murillo José Torelli
name: Segura, Liliane Cristina
name: Geron, Cecília Moraes Santostaso
name: Formigoni, Henrique
Publisher: name: Zenodo
Year: 2023
Subjects: incertezas fiscais
IFRIC 23
ICPC 22

description: As incertezas fiscais tratadas no IFRIC 23/ ICPC 22 têm relação com ajustes efetuados ou não efetuados nos livros contábeis/fiscais de apuração dos tributos sobre o lucro. As decisões para esses ajustes estão relacionadas com as interpretações e decisões dos gestores da empresa além da interpretação do fiscalizador, que no Brasil é feita pela RFB (Receita Federal do Brasil). O produto apresenta um modelo de tomada de decisão no ambiente de incerteza tributária, baseado nas respostas do questionário foi criado uma planilha dinâmica no Excel, onde o usuário aponta os usuários das demonstrações financeiras com o risco fiscal e recebe a recebe as recomendações dos respondentes da pesquisa.
title: Oltre il topos letterario: il locus amoenus come spazio vissuto nei dialoghi ciceroniani
Creators: name: Calcò, Valentina
Publisher: name: Ciceroniana on line
Year: 2018

description: This paper seeks to examine the existential significance of the description of place in Cicero’s works. Descriptions of the locations in which philosophical dialogues are set serve more than an ornamental function, adding an essential element to the discourse. The presence of loci amoeni in the dialogues’ frames constitutes a generic sphragis for the philosophical dialogue, as these loci are imbued with an atmosphere that identifies them as lived spaces. In view of the lack of ancient perspectives on the perception of space, my reading draws on recent phenomenological theories to investigate this theme. The possibility of deploying this modern lens to interpret the ancient material is granted by the transhistorical nature of the object of our study, as characterised in the phenomenological literature: place is not a cultural product, subject to the change, but something universal that concerns an essential aspect of human life. Il contributo mira a mettere in luce il valore esistenziale che può assumere la descrizione di un luogo nell’opera ciceroniana. Le descrizioni dei luoghi in cui sono ambientati i dialoghi filosofici non sono meramente ornamentali, ma aggiungono qualcosa di essenziale al discorso. La presenza dei loci amoeni nelle cornici non solo costituisce una sphragis di genere per il dialogo filosofico, poiché essi possiedono anche un’atmosfera che li connota come spazi vissuti. Pur nell’assenza di una riflessione antica sulla percezione dello spazio, tale aspetto può essere indagato attraverso l’apporto di riflessioni recenti di stampo fenomenologico. La possibilità di impiegare strumenti moderni per leggere l’antico è data dal carattere stesso dell’oggetto di indagine: non un prodotto culturale, soggetto al mutamento del tempo, ma un universale che concerne un aspetto essenziale della vita umana. Cet article vise à mettre en lumière la valeur existentielle qui peut prendre la description d’un lieu dans l’oeuvre cicéronienne. Les descriptions des lieux où se déroulent les dialogues philosophiques n’ont pas une valeur simplement ornementale, mais elles apportent quelque chose d’essentiel au discours: le locus amoenus n’est pas employé seulement comme une vraie sphragis pour le genre du dialogue philosophique, mais il est aussi porteur d’une atmosphère qui lui confère un caractère d’espace vécu. En dépit de l’absence d’une réflexion antique sur la perception de l’espace, cet aspect peut être analysé grâce aux modernes réflexions nées de la phénoménologie. L’emploi de catégories modernes pour lire les classiques est justifié par l’objet même de la recherche: non pas un produit culturel, sujet à l’évolution, mais un universel qui concerne un aspect essentiel de la vie humaine.
description: Ciceroniana on line, V. 2 N. 2 (2018)
Additional file 2 of NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Creators: name: Tsesmelis, Miltiadis
name: Büttner, Ulrike F. G.
name: Gerstenlauer, Melanie
name: Manfras, Uta
name: Tsesmelis, Konstantinos
name: Du, Ziwei
name: Sperb, Nadine
name: Weissinger, Stephanie Ellen
name: Möller, Peter
name: Barth, Thomas F. E.
name: Maier, Harald J.
name: Chan, Lap Kwan
name: Wirth, Thomas
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2.
An Extended Matter Bounce Scenario: current status and challenges
Creators: name: de Haro, Jaume
name: Cai, Yi-Fu
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: As an alternative to the paradigm of slow roll inflation, we propose an extended scenario of the matter bounce cosmology in which the Universe has experienced a quasi-matter contracting phase with a variable background equation of state parameter. This extended matter bounce scenario can be realized by considering a single scalar field evolving along an approximately exponential potential. Our result reveals that the rolling of the scalar field in general leads to a running behavior on the spectral index of primordial cosmological perturbations and a negative running can be realized in this model. We constrain the corresponding parameter space by using the newly released Planck data. To apply this scenario, we revisit bouncing cosmologies within the context of modified gravity theories, in particular, the holonomy corrected loop quantum cosmology and teleparallel $F(T)$ gravity. A gravitational process of reheating is presented in such a matter bounce scenario to demonstrate the condition of satisfying current observations. We also comment on several unresolved issues that often appear in matter bounce models.
description: Final version
Effect of Six Weeks Plyometric Training Program on Arm Strength among Baseball and Volleyball Players
Creators: name: Mr. Ravindra A. Kalane
name: Dr. Bhaskar Reddy S., N.
Publisher: name: Zenodo
Year: 2022
Subjects: Plyometric Training, Baseball, Volleyball Male Players, Arm Strength.

description: Abstract: The objective of this study was to examin.e the effect of six weeks plyometric training program and ability to improve the arms strength in baseball and volleyball players. A total no. of baseball 20 players, volleyball 20 players and control group 20 players selected by simple random sampling method from which participated in intercollegiate level served as subjects of Ahmednagar district. Study was restricted to six weeks plyometric exercise training program. The experimental group implement program to the players by the concerned proper instructions also pre & post test data collected. Statically analyzed by using analysis of variance (ANOVA) and group means were compared. The study concludes better improvement in arm strength of male baseball players compared than volleyball male players.
Additional file 1 of Toxoplasma infection induces an aged neutrophil population in the CNS that is associated with neuronal protection
Creators: name: Bergersen, Kristina V.
name: Kavvathas, Bill
name: Ford, Byron D.
name: Wilson, Emma H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
Characterization of the CpG Island Hypermethylated Phenotype Subclass in Primary Melanomas
Creators: name: Hao, H.
name: Kuan, P.F.
name: Scott, G.A.
name: Thomas, N.E.
name: Conway, K.
name: Ollila, D.W.
name: Frank, J.S.
name: Edmiston, S.N.
name: Parker, J.S.
name: Tsai, Y.S.
name: Googe, P.
name: Parrish, E.A.
Publisher: name: Elsevier B.V.
Year: 2022

description: Cutaneous melanoma can be lethal even if detected at an early stage. Epigenetic profiling may facilitate the identification of aggressive primary melanomas with unfavorable outcomes. We performed clustering of whole-genome methylation data to identify subclasses that were then assessed for survival, clinical features, methylation patterns, and biological pathways. Among 89 cutaneous primary invasive melanomas, we identified three methylation subclasses exhibiting low methylation, intermediate methylation, or hypermethylation of CpG islands, known as the CpG island methylator phenotype (CIMP). CIMP melanomas occurred as early as tumor stage 1b and, compared with low-methylation melanomas, were associated with age at diagnosis ≥65 years, lentigo maligna melanoma histologic subtype, presence of ulceration, higher American Joint Committee on Cancer stage and tumor stage, and lower tumor-infiltrating lymphocyte grade (all P < 0.05). Patients with CIMP melanomas had worse melanoma-specific survival (hazard ratio = 11.84; confidence interval = 4.65‒30.20) than those with low-methylation melanomas, adjusted for age, sex, American Joint Committee on Cancer stage, and tumor-infiltrating lymphocyte grade. Genes hypermethylated in CIMP compared with those in low-methylation melanomas included PTEN, VDR, PD-L1, TET2, and gene sets related to development/differentiation, the extracellular matrix, and immunity. CIMP melanomas exhibited hypermethylation of genes important in melanoma progression and tumor immunity, and although present in some early melanomas, CIMP was associated with worse survival independent of known prognostic factors.
Search for charged Higgs bosons decaying via $H^{\pm} \rightarrow τ^{\pm}ν$ in fully hadronic final states using $pp$ collision data at $\sqrt{s} = 8$ TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The results of a search for charged Higgs bosons decaying to a $τ$ lepton and a neutrino, $H^{\pm} \rightarrow τ^{\pm} ν$, are presented. The analysis is based on 19.5 fb$^{-1}$ of proton-proton collision data at $\sqrt{s}=8$ TeV collected by the ATLAS experiment at the Large Hadron Collider. Charged Higgs bosons are searched for in events consistent with top-quark pair production or in associated production with a top quark. The final state is characterised by the presence of a hadronic $τ$ decay, missing transverse momentum, $b$-tagged jets, a hadronically decaying $W$ boson, and the absence of any isolated electrons or muons with high transverse momenta. The data are consistent with the expected background from Standard Model processes. A statistical analysis leads to 95\% confidence-level upper limits on the product of branching ratios $ {\cal B}(t\rightarrow bH^\pm) \times {\cal B} (H^\pm\rightarrow τ^{\pm}ν) $, between 0.23% and 1.3% for charged Higgs boson masses in the range 80-160 GeV. It also leads to 95% confidence-level upper limits on the production cross section times branching ratio, $σ(pp \rightarrow tH^{\pm} + X) \times {\cal B}(H^{\pm} \rightarrow τ^{\pm} ν)$, between 0.76 pb and 4.5 fb, for charged Higgs boson masses ranging from 180 GeV to 1000 GeV. In the context of different scenarios of the Minimal Supersymmetric Standard Model, these results exclude nearly all values of $\tanβ$ above one for charged Higgs boson masses between 80 GeV and 160 GeV, and exclude a region of parameter space with high $\tanβ$ for $H^{\pm}$ masses between 200 GeV and 250 GeV.
description: 27 pages plus author list + cover pages (50 pages total), 8 figures, 5 tables, submitted to JHEP, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2013-30/. arXiv admin note: text overlap with arXiv:1204.2760
Long-term climate variability of the Baltic Sea region
Creators: name: Börgel, Florian
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 530 Physics

description: This thesis analyzes the impact of the Atlantic Multidecadal Oscillation (AMO) on North European climate and traces the AMO signal into the Baltic Sea region. With a frequency of 50 - 90 years, effects of the AMO are difficult to evaluate, since observations are limited to about 150 years. To overcome this lack of observational data, a combination of a general circulation model (GCM) and a regional climate model (RCM) is used to analyze the preindustrial period from 950 - 1800. In summary, this work shows that the AMO plays an important role for the climate of the Baltic Sea.
Additional file 2 of Multilocus sequence typing and phenotypic properties of Streptococcus mutans from Thai children with different caries statuses
Creators: name: Lapirattanakul, Jinthana
name: Nomura, Ryota
name: Okawa, Rena
name: Tantivitayakul, Pornpen
name: Kaypetch, Rattiporn
name: Lehrkinder, Anna
name: Lingström, Peter
name: Birkhed, Dowen
name: Matsumoto-Nakano, Michiyo
name: Nakano, Kazuhiko
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Table S2 Allelic profiles and STs of 115 S. mutans strains from the Oral Streptococcus PubMLST database.
Warped Conformal Field Theory as Lower Spin Gravity
Creators: name: Hofman, Diego M.
name: Rollier, Blaise
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Two dimensional Warped Conformal Field Theories (WCFTs) may represent the simplest examples of field theories without Lorentz invariance that can be described holographically. As such they constitute a natural window into holography in non AdS space-times, including the near horizon geometry of generic extremal black holes. It is shown in this paper that WCFTs posses a type of boost symmetry. Using this insight, we discuss how to couple these theories to background geometry. This geometry is not Riemannian. We call it Warped Geometry and it turns out to be a variant of a Newton-Cartan structure with additional scaling symmetries. With this formalism the equivalent of Weyl invariance in these theories is presented and we write two explicit examples of WCFTs. These are free fermionic theories. Lastly we present a systematic description of the holographic duals of WCFTs. It is argued that the minimal setup is not Einstein gravity but an SL(2,R) x U(1) Chern-Simons Theory, which we call Lower Spin Gravity. This point of view makes manifest the definition of boundary for these non AdS geometries. This case represents the first step towards understanding a fully invariant formalism for W_N field theories and their holographic duals.
description: 53 pages, v3: matches version published in Nuclear Physics B
PHYSICAL COORDINATION AS A CUE OF FORMIDABILITY
Creators: name: Penate, Michael Andrew
Publisher: name: Zenodo
Year: 2023
Subjects: coordination
formidability
assessment mechanisms

description: Violent conflict and other costly behaviors can often be the result of competition that can occur between conspecifics living within a local area. Consequently, animals that possessed psychological mechanisms that allowed for the ability to estimate a potential threat’s formidability were much better fit for survival. Correspondingly, there are vast amount of literature that suggests humans possess internal mechanisms that allow for the accurate assessment of formidability of another human based of reliable cues similar to animals. Consequently, this study sought to further contribute to the current formidability assessment literature by offering coordination as another reliable cue of formidability. The current study hypothesized that coordinated individuals will be seen as more formidable than uncoordinated individuals. Results of these analyses suggest that coordination does influence perceptions surrounding formidability. Specifically, coordinated individuals were perceived as stronger, more physically attractive, more entitled, having experienced more fights, appearing physically tougher, and as better fighters than uncoordinated individuals.
Prognostic significance of RNA-based TP53 pathway function among estrogen receptor positive and negative breast cancer cases
Creators: name: Olshan, A.F.
name: Hurson, A.N.
name: Conway, K.
name: Hoadley, K.A.
name: Perou, C.M.
name: Garcia-Closas, M.
name: Abubakar, M.
name: Love, M.I.
name: Hamilton, A.M.
name: Troester, M.A.
Publisher: name: Nature Research
Year: 2022

description: TP53 and estrogen receptor (ER) are essential in breast cancer development and progression, but TP53 status (by DNA sequencing or protein expression) has been inconsistently associated with survival. We evaluated whether RNA-based TP53 classifiers are related to survival. Participants included 3213 women in the Carolina Breast Cancer Study (CBCS) with invasive breast cancer (stages I–III). Tumors were classified for TP53 status (mutant-like/wildtype-like) using an RNA signature. We used Cox proportional hazards models to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer-specific survival (BCSS) among ER- and TP53-defined subtypes. RNA-based results were compared to DNA- and IHC-based TP53 classification, as well as Basal-like versus non-Basal-like subtype. Findings from the diverse (50% Black), population-based CBCS were compared to those from the largely white METABRIC study. RNA-based TP53 mutant-like was associated with BCSS among both ER-negatives and ER-positives (HR (95% CI) = 5.38 (1.84–15.78) and 4.66 (1.79–12.15), respectively). Associations were attenuated when using DNA- or IHC-based TP53 classification. In METABRIC, few ER-negative tumors were TP53-wildtype-like, but TP53 status was a strong predictor of BCSS among ER-positives. In both populations, the effect of TP53 mutant-like status was similar to that for Basal-like subtype. RNA-based measures of TP53 status are strongly associated with BCSS and may have value among ER-negative cancers where few prognostic markers have been robustly validated. Given the role of TP53 in chemotherapeutic response, RNA-based TP53 as a prognostic biomarker could address an unmet need in breast cancer.