cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supporting Spectral and Mass Characterization from De novo synthetic biliprotein design, assembly and excitation energy transfer
Creators: name: Mancini, Joshua A.
name: Sheehan, Molly
name: Goutham Kodali
name: Chow, Brian Y.
name: Bryant, Donald A.
name: P. Leslie Dutton
name: Moser, Christopher C.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 60104 Cell Metabolism
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: Bilins are linear tetrapyrrole chromophores with a wide range of visible and near-visible light absorption and emission properties. These properties are tuned upon binding to natural proteins and exploited in photosynthetic light-harvesting and non-photosynthetic light-sensitive signalling. These pigmented proteins are now being manipulated to develop fluorescent experimental tools. To engineer the optical properties of bound bilins for specific applications more flexibly, we have used first principles of protein folding to design novel, stable and highly adaptable bilin-binding four-α-helix bundle protein frames, called maquettes, and explored the minimal requirements underlying covalent bilin ligation and conformational restriction responsible for the strong and variable absorbance, fluorescence and excitation energy transfer of these proteins. Biliverdin, phycocyanobilin and phycoerythrobilin bind covalently to maquette cysteines (Cys) in vitro. A blue-shifted tripyrrole (TPB) formed from maquette-bound PCB displays a quantum yield of 26%. Although unrelated in fold and sequence to natural phycobiliproteins, bilin lyases nevertheless interact with maquettes during co-expression in Escherichia coli to improve the efficiency of bilin binding and alter bilin conformation. Bilins bind in vitro and in vivo to Cys residues placed in loops, towards the amino end or in the middle of helices but bind poorly at the carboxyl end of helices. Bilin-binding efficiency and fluorescence yield are improved by Arg and Asp residues adjacent to the ligating Cys on the same helix and by His residues on adjacent helices.
Ulipristal Acetate: A Review in Uterine Fibroids
Creators: name: Garnock-Jones, Karly
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine

description: Compliance with Ethical Standards Funding: The preparation of this review was not supported by any external funding. Conflicts of interest: Karly P. Garnock-Jones is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here. Abstract Oral ulipristal acetate (Esmya®; Fibristal®), a synthetic selective progesterone receptor modulator, is the first selective progesterone modulator to be approved for the treatment of uterine fibroids. It was initially approved for the preoperative treatment of moderate to severe uterine fibroid symptoms in women of reproductive age. Recently, the indication was extended in the EU to include the intermittent treatment of moderate to severe uterine fibroid symptoms. This narrative review summarizes pharmacological, efficacy and tolerability data relevant to the preoperative and intermittent use of ulipristal acetate in patients with symptomatic uterine fibroids. Ulipristal acetate is an effective and generally well tolerated treatment for patients with symptomatic uterine fibroids, both as preoperative, single-course treatment and as intermittent, longer-term treatment. It is noninferior in efficacy to intramuscular leuprolide acetate, as a preoperative treatment, and is associated with a lower rate of hot flashes, a common adverse event with gonadotropin-releasing hormone analogues. Thus, ulipristal acetate is an effective option for both preoperative and intermittent treatment of moderate to severe, symptomatic uterine fibroids in women of reproductive age. Access to the full article can be found here. © Springer International Publishing AG, part of Springer Nature 2017
GP2015: An Etanercept Biosimilar
Creators: name: Deeks, Emma D.
Publisher: name: Adis Journals
Year: 2019
Subjects: subject: Medicine
subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Compliance with Ethical Standards Disclosure: The preparation of this review was not supported by any external funding. Emma Deeks is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here. Abstract GP2015 is the second biosimilar of the reference p75 TNF receptor-Fc fusion protein etanercept. It is approved for use in all indications for which reference etanercept is approved, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis and paediatric plaque psoriasis. GP2015 has similar physiochemical and pharmacodynamic properties to those of reference etanercept, and the pharmacokinetic biosimilarity of the agents has been shown in healthy volunteers. GP2015 demonstrated clinical efficacy equivalent to that of reference etanercept in patients with moderate-to-severe plaque psoriasis; the tolerability, safety and immunogenicity profiles of the two agents were also generally similar. Switching between GP2015 and reference etanercept had no impact on clinical efficacy, tolerability or immunogenicity. The role of reference etanercept in the management of inflammatory autoimmune conditions is well established and GP2015 provides an effective biosimilar alternative for patients requiring etanercept therapy. Access to the full article can be found here. © Springer International Publishing AG, part of Springer Nature 2017
GP2015: An Etanercept Biosimilar
Creators: name: Deeks, Emma D.
Publisher: name: Adis Journals
Year: 2018
Subjects: subject: Medicine
subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Compliance with Ethical Standards Disclosure: The preparation of this review was not supported by any external funding. Emma Deeks is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here. Abstract GP2015 is the second biosimilar of the reference p75 TNF receptor-Fc fusion protein etanercept. It is approved for use in all indications for which reference etanercept is approved, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis and paediatric plaque psoriasis. GP2015 has similar physiochemical and pharmacodynamic properties to those of reference etanercept, and the pharmacokinetic biosimilarity of the agents has been shown in healthy volunteers. GP2015 demonstrated clinical efficacy equivalent to that of reference etanercept in patients with moderate-to-severe plaque psoriasis; the tolerability, safety and immunogenicity profiles of the two agents were also generally similar. Switching between GP2015 and reference etanercept had no impact on clinical efficacy, tolerability or immunogenicity. The role of reference etanercept in the management of inflammatory autoimmune conditions is well established and GP2015 provides an effective biosimilar alternative for patients requiring etanercept therapy. Access to the full article can be found here. © Springer International Publishing AG, part of Springer Nature 2017
Relating CKM Parametrizations and Unitarity Triangles
Creators: name: Lebed, Richard F.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Concise variable transformations between the four angles of the CKM matrix in the standard representation advocated by the Particle Data Group and the angles of the unitarity triangles are derived. The behavior of these transformations in various limits is explored. The straightforward extension of this calculation to other representations and more generations is indicated.
description: 14 pages, 1 epsf figure, uses revtex and hyperlatex
Investigation into the crystal morphology and acidity of LLM-105 in recrystallization
Creators: name: Chang, Shuang-Jun
name: Wang, Jiu-Ning
name: Wu, Hao
name: Qin, Liang
name: Wang, Na
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Sensitivities and compatibilities of the explosives are greatly influenced by their crystal morphology and acidity. In order to improve the crystal morphology and reduce the acidity, a molecular dynamics simulation of the recrystallization of LLM-105 (2,6-diamino-3,5-dinitropyrazine-1-oxide) with nitric acid as solvent were carried out, and the influences of the process conditions on the acidity of LLM-105 in the process of recrystallization were investigated by the solvent–antisolvent method. The result shows that the nitric acid concentration, water bath temperature, undercooling, stirring speed and dropping mode have the significant effect on acidity. The LLM-105 crystal obtained from the recrystallization with the dropping mode by normal phase, HNO3 (85%) as solvent, water bath temperature of 70°C, anti-solvent temperature of 60°C, dropping rate of 12.5 ml/min and stirring speed of 330 r/min has the regular morphology (blocky and inclined prismatic) and good fluidity, with the acidity less than 0.05% (calculated by HNO3). By means of the mechanical sensitivity and differential heat analysis, the impact sensitivity and friction sensitivity of the LLM-105 crystal from the recrystallization were decreased by 58.4% and 20%, respectively, and the exothermic peak was increased by 14.6°C in comparison with the raw material.
A study protocol for a simulation study to test the efficacy of statistical and design interventions to improve reproducibility in biomedical research
Creators: name: Wever, Kimberley
name: Voelkl, Bernhard
name: Nilsonne, Gustav
name: Zellers, Stephanie
name: Heyard, Rachel
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Physical Sciences and Mathematics
subject: Medicine and Health Sciences
subject: Life Sciences
subject: iRISE
subject: intervention study
subject: reproducibility
subject: statistical methods
subject: study protocol

description: This is the pre-registration for one of the intervention studies initiated by the iRISE (improving the Reproducibility in SciencE, https://www.irise-project.eu/) consortium, a project that receives funding from the European Union's Horizon Europe research and innovation programme under grant agreement No 101094853. iRISE also receives funding from the Swiss State Secretariat for Education, Research and Innovation (SERI): Direct Funding for Collaborative Projects as part of the transitional measures, and from UK Research and Innovation (UKRI). The protocols for all intervention studies follow a template, available from the iRISE open knowledge base (https://osf.io/x95u3). The registration of this protocol is part of a deliverable due by “Work package 5.5 - Testing interventions”.
Soliton splitting by external delta potentials
Creators: name: Holmer, Justin
name: Marzuola, Jeremy
name: Zworski, Maciej
Publisher: name: arXiv
Year: 2006
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We show that a soliton scattered by an external delta potential splits into two solitons and a radiation term. Theoretical analysis gives the amplitudes and phases of the reflected and transmitted solitons with errors going to zero as the velocity of the incoming soliton tends to infinity. Numerical analysis shows that this asymptotic relation is valid for all but very slow solitons. We also show that the total transmitted mass, that is the square of the $L^2$ norm of the solution restricted on the transmitted side of the delta potential is in good agreement with the quantum transmission rate of the delta potential. This paper is a numerical companion to our analytical paper on the same topic, "Fast soliton scattering by delta impurities," math.AP/0602187.
Crassula cultrata Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula cultrata

description: Crassula cultrata, spec. nov.
 4. Crassula foliis oppositis obtuse ovatis integerrimis: hinc angustioribus. Hort. cliff. 496. Roy. lugdb. 455.
 Crassula anacampserotis folio. Dill. elth. 115. t.97. f.114.
 Habitat in AEthiopia . ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Avaliação do efeito da recirculação de lixiviados num aterro sanitário.
Creators: name: Brás, Isabel Paula Lopes
name: Ferreira, Bruna Sofia
name: Silva, Maria Elisabete Ferreira
Publisher: name: Millenium - Journal of Education, Technologies, and Health
Year: 2017

description: Introdução: O aterro sanitário é uma técnica que aplica princípios de engenharia para confinar os resíduos numa menor área possível, reduzindo o seu volume. Deste tratamento resultam nomeadamente a produção de lixiviados, pelo que se impõe o estudo da sua recirculação. Objetivos: Fornecer uma perspetiva da prática do efeito da recirculação de lixiviados e de questões técnicas que o diferenciam dos aterros convencionais, tendo por base o aterro sanitário de Bigorne. Métodos: Efetuou-se o levantamento de diversos parâmetros físicos e químicos durante um período de 10 anos exploração do aterro, seguindo-se o respectivo tratamento estatístico. Resultados: A análise dos dados mostrou que a produção de lixiviados diminui com o início da recirculação de lixiviados, assim como a condutividade, após um aumento gradual, a carência bioquímica de O2 (CBO5) e carência química de O2 (CQO). Por sua vez, a concentração de azoto amoniacal tende a permanecer elevada e o pH aumenta para valores com caracter básico. As concentrações dos elementos minerais apresentaram um perfil variável. O chumbo e manganês tendem a diminuir, enquanto as concentrações dos elementos crómio, sódio e potássio tendem a aumentar. Quanto aos restantes elementos minerais (zinco, cobre, ferro, níquel, magnésio e cálcio), verifica-se que as suas concentrações tendem a se manter constantes. A maioria das correlações efetuadas entre a idade do aterro, o caudal recirculado e os elementos minerais não evidenciou correlações significativas. Salienta-se apenas a correlação significativa positiva entre o caudal recirculado com o crómio e potássio, evidenciando o efeito do caudal no aumento da concentração destes elementos minerais no interior do aterro. Conclusões: Estudar os mecanismos que controlam o comportamento de aterros com recirculação de lixiviados, permite o desenvolvimento de ferramentas de gestão adequadas às especificidades dos aterros.
description: Millenium - Journal of Education, Technologies, and Health, Series 2, no. 2e: special edition: june 2017
Comment on ``The Dispersion Velocity of Galactic Dark Matter Particles''
Creators: name: Gates, Evalyn
name: Kamionkowski, Marc
name: Turner, Michael S.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In a recent Letter (astro-ph/9605001), Cowsik et al. claim that a self-consistent treatment of the dark Galactic halo requires that the local velocity dispersion of dark-matter particles be $600$ km~s$^{-1}$ or greater, more than a factor of two larger than the canonical value of 270 km~s$^{-1}$. If true, this would significantly affect rates and signatures for detection of baryonic and nonbaryonic dark matter. We believe that this work is incorrect, probably because not all the observational constraints were taken into account and because the models were forced to satisfy arbitrary constraints on the halo density.
description: 4 pages, RevTeX, submitted to Physical Review Letters
IAEVG 2016 – międzynarodowa konferencja: Promoting Equity Through Guidance: Reflections, Actions and Impact (Promowanie równości poprzez doradztwo: działania, refleksje i wpływ), 15–18 listopada 2016, Madryt
Creators: name: Gorna, Joanna
Publisher: name: Studia Poradoznawcze
Year: 2019

description: Studia Poradoznawcze, Tom 5 (2016)
White, Man, and Highly Followed: Gender and Race Inequalities in Twitter
Creators: name: Messias, Johnnatan
name: Vikatos, Pantelis
name: Benevenuto, Fabricio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Social media is considered a democratic space in which people connect and interact with each other regardless of their gender, race, or any other demographic factor. Despite numerous efforts that explore demographic factors in social media, it is still unclear whether social media perpetuates old inequalities from the offline world. In this paper, we attempt to identify gender and race of Twitter users located in U.S. using advanced image processing algorithms from Face++. Then, we investigate how different demographic groups (i.e. male/female, Asian/Black/White) connect with other. We quantify to what extent one group follow and interact with each other and the extent to which these connections and interactions reflect in inequalities in Twitter. Our analysis shows that users identified as White and male tend to attain higher positions in Twitter, in terms of the number of followers and number of times in user's lists. We hope our effort can stimulate the development of new theories of demographic information in the online space.
description: In Proceedings of the IEEE/WIC/ACM International Conference on Web Intelligence (WI'17). Leipzig, Germany. August 2017
Spark discharge modeling in internal combustion engines
Creators: name: Pyszczek, Rafał
name: Hahn, Jooyoung
name: Prieshing, Peter
name: Teodorczyk, Andrzej
Publisher: name: Zenodo
Year: 2018

description: The spark ignition model has been extensively investigated in a number of studies in the past and is well understood. However, the complexity of ignition process brings a lot of difficulties to correctly describe a whole physical model. Many RANS and LES studies of this phenomenon have been carried out in a certain accuracy depending on the simplifications and physically reasonable assumptions. In order to comprehensively describe spark ignition process we propose to combine specific sub-models describing individual phenomena of the spark ignition into one ignition model.
On Words with the Zero Palindromic Defect
Creators: name: Pelantová, Edita
name: Starosta, Štěpán
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 68R15

description: We study the set of finite words with zero palindromic defect, i.e., words rich in palindromes. This set is factorial, but not recurrent. We focus on description of pairs of rich words which cannot occur simultaneously as factors of a longer rich word.
Z' Search in e+e- Annihilation
Creators: name: Leike, A.
name: Riemann, S.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Expectations for constraints on extra Z bosons are derived for LEP 2 and future linear e+e- colliders. For typical GUTs, a Z' with M_{Z'} \le 3 to 6 \sqrt{s} may cause observable effects. The Z' discovery limits are dominated by statistical errors. However, if a Z' signal is observed, the discrimination between different models becomes much worse if systematic errors are taken into account. Discrimination between models is possible for M_{Z'} < 3 \sqrt{s}. A determination of Z' f \bar f couplings independently of models becomes attractive with future colliders. Anticipated bounds are determined.
description: 15 pages, LaTex, 11 figures, 3 tables; table 3 changed. Version to appear in Zeitschrift f. Physik C
Modulating synaptic plasticity with acute exercise and cardiorespiratory fitness in health and ageing
Creators: name: CADWALLADER, CLAIRE JEAN
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 520203
subject: Cognitive neuroscience

description: This thesis was motivated by evidence showing the benefits of exercise for brain plasticity - a mechanism that underlies memory, and shows a decline with ageing. A single session of exercise had an effect on plasticity in the visual area of the brain. Additionally, the boost in plasticity seen following a single session of exercise was a mechanism that explained the positive relationship between fitness and memory function in older adults. These findings show the widespread effects of exercise in the brain, and contribute to evidence of the benefits of exercise for supporting memory in ageing.
Copanlisib: First Global Approval
Creators: name: Markham, Anthony
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine
Cancer

description: Compliance with Ethical Standards
Funding: The preparation of this review was not supported by any external funding.
Conflicts of interest: A. Markham is a contracted employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.
Additional information about this Adis Drug Review can be found here.
Abstract
Bayer are developing copanlisib (Aliqopa™) – a pan-class I phosphoinositide 3-kinase (PI3K) inhibitor – as a treatment for various haematological and solid malignancies. The US FDA has granted copanlisib accelerated approval for the treatment of adults with relapsed follicular lymphoma who have received at least two prior treatments based on the results of a phase II trial. Phase III trials are underway evaluating copanlisib as treatment for relapsed/refractory diffuse large B-cell lymphoma and in combination with rituximab or rituximab-based chemotherapy or standard immunochemotherapy in patients with relapsed indolent B-cell non-Hodgkin's lymphoma. Phase I/II studies are underway in relapsed or refractory peripheral T-cell or NK/T-cell lymphoma, advanced cholangiocarcinoma, hormone receptor-positive HER2-negative stage I-IV breast cancer, HER2-positive breast cancer and recurrent and/or metastatic head and neck squamous cell carcinomas harbouring a PI3KCA mutation/amplification and/or a PTEN loss. This article summarizes the milestones in the development of copanlisib leading to this first approval for relapsed follicular lymphoma.Access to the full article can be found here.
© Springer International Publishing AG, part of Springer Nature 2017
Nonlinear theory of transverse beam echoes
Creators: name: Sen, Tanaji
name: Li, Yuan Shen
Publisher: name: arXiv
Year: 2017
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Transverse beam echoes can be excited with a single dipole kick followed by a single quadrupole kick. They have been used to measure diffusion in hadron beams and have other diagnostic capabilities. Here we develop theories of the transverse echo nonlinear in both the dipole and quadrupole kick strengths. The theories predict the maximum echo amplitudes and the optimum strength parameters. We find that the echo amplitude increases with smaller beam emittance and the asymptotic echo amplitude can exceed half the initial dipole kick amplitude. We show that multiple echoes can be observed provided the dipole kick is large enough. The spectrum of the echo pulse can be used to determine the nonlinear detuning parameter with small amplitude dipole kicks. Simulations are performed to check the theoretical predictions. In the useful ranges of dipole and quadrupole strengths, they are shown to be in reasonable agreement.
description: 32 pages, 11 figures
Crassula ciliata Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula ciliata

description: Crassula ciliata, spec. nov.
 5. Crassula foliis oppositis oblongis planiusculis distinctis ciliatis. Hort. cliff. 496. Roy. lugdb. 455.
 Crassula caulescens, foliis sempervivi cruciatis. Dill. elth. 116. t.98. f.116.
 Habitat in AEthiopia . ♃
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Democratic Fair Allocation of Indivisible Goods
Creators: name: Segal-Halevi, Erel
name: Suksompong, Warut
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: We study the problem of fairly allocating indivisible goods to groups of agents. Agents in the same group share the same set of goods even though they may have different preferences. Previous work has focused on unanimous fairness, in which all agents in each group must agree that their group's share is fair. Under this strict requirement, fair allocations exist only for small groups. We introduce the concept of democratic fairness, which aims to satisfy a certain fraction of the agents in each group. This concept is better suited to large groups such as cities or countries. We present protocols for democratic fair allocation among two or more arbitrarily large groups of agents with monotonic, additive, or binary valuations. For two groups with arbitrary monotonic valuations, we give an efficient protocol that guarantees envy-freeness up to one good for at least $1/2$ of the agents in each group, and prove that the $1/2$ fraction is optimal. We also present other protocols that make weaker fairness guarantees to more agents in each group, or to more groups. Our protocols combine techniques from different fields, including combinatorial game theory, cake cutting, and voting.
description: Appears in the 27th International Joint Conference on Artificial Intelligence and the 23rd European Conference on Artificial Intelligence (IJCAI-ECAI), 2018
Crassula scabra Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula scabra

description: Crassula scabra, spec. nov.
6. Crassula foliis oppositis patentibus scabris.
 Crassula mesembryanthemi facie, foliis longioribus asperis. Dill. elth. 117. t.99. f.117.
 Cotyledon africana frutescens, foliis asperis angustis acuminatis, flore virescente. Mart. cent. 24. t.24.
 Habitat in Africa ?
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Crassula alternifolia Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula alternifolia

description: Crassula alternifolia, spec. nov.
 7. Crassula foliis serrato-dentatis planis alternis, caule simplicissimo, floribus pendulis. Hort. cliff. 497. * Roy. lugdb. 455.
 Cotyledon, flore luteo, media. Herm. lugdb. 191.
 Habitat - - - - -
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Linking connectivity, dynamics and computations in low-rank recurrent neural networks
Creators: name: Mastrogiuseppe, Francesca
name: Ostojic, Srdjan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Large scale neural recordings have established that the transformation of sensory stimuli into motor outputs relies on low-dimensional dynamics at the population level, while individual neurons exhibit complex selectivity. Understanding how low-dimensional computations on mixed, distributed representations emerge from the structure of the recurrent connectivity and inputs to cortical networks is a major challenge. Here, we study a class of recurrent network models in which the connectivity is a sum of a random part and a minimal, low-dimensional structure. We show that, in such networks, the dynamics are low dimensional and can be directly inferred from connectivity using a geometrical approach. We exploit this understanding to determine minimal connectivity required to implement specific computations, and find that the dynamical range and computational capacity quickly increase with the dimensionality of the connectivity structure. This framework produces testable experimental predictions for the relationship between connectivity, low-dimensional dynamics and computational features of recorded neurons.
Crassula nudicaulis Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula nudicaulis

description: Crassula nudicaulis, spec. nov.
 8. Crassula foliis subulatis radicatis, caule nudo. Hort. cliff. 116. Roy. lugdb. 455.
 Crassula cesposa longifolia. Dill. elth. 116. t.98. f.115.
 Habitat in AEthiopia . ♃
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Crassula orbicularis Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula orbicularis

description: Crassula orbicularis, spec. nov.
 9. Crassula caule flaccido prolifero determinate-folioso, foliis patentissimis imbricatis. Hort. cliff. 496. Roy. lugdb. 455.
 Crassula orbicularis repens, foliis sempervivi. Dill. elth. 119. t.100. f.118.
 Habitat in AEthiopia . ♃
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Minkowski Functionals of Abell/ACO Clusters
Creators: name: Kerscher, M.
name: Schmalzing, J.
name: Retzlaff, J.
name: Borgani, S.
name: Buchert, T.
name: Gottl"ober, S.
name: M"uller, V.
name: Plionis, M.
name: Wagner, H.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We determine the Minkowski functionals for a sample of Abell/ACO clusters, 401 with measured and 16 with estimated redshifts. The four Minkowski functionals (including the void probability function and the mean genus) deliver a global description of the spatial distribution of clusters on scales from $10$ to $60\hMpc$ with a clear geometric interpretation. Comparisons with mock catalogues of N--body simulations using different variants of the CDM model demonstrate the discriminative power of the description. The standard CDM model and the model with tilted perturbation spectrum cannot generate the Minkowski functionals of the cluster data, while a model with a cosmological constant and a model with breaking of the scale invariance of perturbations (BSI) yield compatible results.
description: 10 pages, 13 Postscript figures, uses epsf.sty and mn.sty (included), submitted to MNRAS
The glitch activity of neutron stars
Creators: name: Fuentes, J. R.
name: Espinoza, C. M.
name: Reisenegger, A.
name: Stappers, B. W.
name: Shaw, B.
name: Lyne, A. G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a statistical study of the glitch population and the behaviour of the glitch activity across the known population of neutron stars. An unbiased glitch database was put together based on systematic searches of radio timing data of 898 rotation-powered pulsars obtained with the Jodrell Bank and Parkes observatories. Glitches identified in similar searches of 5 magnetars were also included. The database contains 384 glitches found in the rotation of 141 of these neutron stars. We confirm that the glitch size distribution is at least bimodal, with one sharp peak at approximately $20\, \rm{μ\,Hz}$, which we call large glitches, and a broader distribution of smaller glitches. We also explored how the glitch activity $\dotν_{\rm{g}}$, defined as the mean frequency increment per unit of time due to glitches, correlates with the spin frequency $ν$, spin-down rate $|\dotν|$, and various combinations of these, such as energy loss rate, magnetic field, and spin-down age. It is found that the activity is insensitive to the magnetic field and that it correlates strongly with the energy loss rate, though magnetars deviate from the trend defined by the rotation-powered pulsars. However, we find that a constant ratio $\dotν_{\rm{g}}/|\dotν| = 0.010 \pm 0.001$ is consistent with the behaviour of all rotation-powered pulsars and magnetars. This relation is dominated by large glitches, which occur at a rate directly proportional to $|\dotν|$. The only exception are the rotation-powered pulsars with the highest values of $|\dotν|$, such as the Crab pulsar and PSR B0540$-$69, which exhibit a much smaller glitch activity, intrinsically different from each other and from the rest of the population. The activity due to small glitches also shows an increasing trend with $|\dotν|$, but this relation is biased by selection effects.
description: Accepted for publication in A&A
Olmesartan medoxomil/amlodipine/hydrochlorothiazide 20 mg/5 mg/12.5 mg fixed-dose combination in hypertension: a profile of its use
Creators: name: Lyseng-Williamson, Katherine A.
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine

description: Conflicts of interest: K.A. Lyseng-Williamson is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Funding: The preparation of this review was not supported by any external funding. Additional information about this Adis Drug Review may be found here. Abstract The triple-component fixed-dose combination of olmesartan medoxomil (OLM)/amlodipine (AML)/hydrochlorothiazide (HCT) is a rational choice for patients who require treatment with three or more antihypertensives. The three drugs in the FDC have complementary mechanisms of action, with OLM, AML and HCT being an angiotensin II receptor blocker, calcium channel blocker and diuretic, respectively. Once-daily OLM/AML/HCT 20 mg/5 mg/12.5 mg reduced systolic and diastolic blood pressure, thereby enabling patients to achieve blood pressure goals, and was generally well tolerated in clinical trials. Moreover, the use of a fixed-dose combination comprising three antihypertensive components reduces pill burden, which may improve patient adherence to treatment and, ultimately, clinical outcomes. Access to the full article can be found here.

 © Springer International Publishing AG, part of Springer Nature 2017
Effects of an intermediate scale in SUSY grand unification
Creators: name: Deshpande, N. G.
name: Dutta, B.
name: Keith, E.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the production of lepton flavor violation and EDMs and the viability of the $b-τ$ unification hypothesis in SUSY grand unification with an intermediate gauge symmetry breaking scale.
description: 3 pages (Latex, esprc2.sty used), talk given at 4th International Conference on Supersymmetry (SUSY '96, College Park, MD, May 29 - June 1, 1996)
Crassula pellucida Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Crassula
Crassula pellucida

description: Crassula pellucida, spec. nov.
10. Crassula caule flaccido repente, foliis oppositis.
 Crassula, portulacae facie, repens. Dill. elth. 119. t.100. f.119.
 Habitat in AEthiopia .
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 283, DOI: 10.5281/zenodo.3931989
Aripiprazole Lauroxil: A Review in Schizophrenia
Creators: name: Frampton, James E
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine

description: Compliance with Ethical Standards Funding: The preparation of this review was not supported by any external funding. Conflicts of interest: James Frampton is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here. Abstract Aripiprazole lauroxil long-acting injectable (LAI) [Aristada®] is an intramuscularly administered, extended-release prodrug of aripiprazole, an established atypical antipsychotic agent that, in terms of its relative position within the class, is at the low end of the risk spectrum for metabolic side effects. In the USA, aripiprazole lauroxil LAI is indicated for the treatment of schizophrenia; approved doses of the drug can be injected once-monthly (q4w), every 6 weeks (q6w) or every 2 months (q8w). The efficacy of the 441 and 882 mg q4w dosages in the treatment of acute exacerbations of schizophrenia and as long-term maintenance therapy in stable schizophrenia has been directly demonstrated in a phase III clinical trial and extension, while the efficacy of the 662 mg q4w, 882 mg q6w and 1064 mg q8w dosing regimens has been established on the basis of pharmacokinetic bridging studies. Aripiprazole lauroxil LAI therapy was generally well tolerated, with an adverse event profile consistent with that of oral aripiprazole (with the exception of injection-site reactions), including a low propensity to cause metabolic disturbances. Thus, aripiprazole lauroxil LAI extends the treatment regimen options for patients with schizophrenia; as with other LAI formulations of antipsychotic agents, it can be particularly recommended for patients with recurrent relapses related to nonadherence to oral preparations and for those who prefer this mode of administration. Moreover, unlike aripiprazole monohydrate LAI, the only other commercially available long-acting formulation of aripiprazole, aripiprazole lauroxil LAI offers more than one dosing interval option, which may be a potential advantage in terms of tailoring therapy to the needs of individual patients. Access to the full article can be found here. © Springer International Publishing AG, part of Springer Nature 2017
The MACHO Project 2nd Year LMC Microlensing Results and Dark Matter Implications
Creators: name: Pratt, M. R.
name: Alcock, C.
name: Allsman, R. A.
name: Alves, D.
name: Axelrod, T. S.
name: Becker, A. C.
name: Bennett, D. P.
name: Cook, K. H.
name: Freeman, K. C.
name: Griest, K.
name: Guern, J.
name: Lehner, M. J.
name: Marshall, S. L.
name: Peterson, B. A.
name: Quinn, P. J.
name: Rodgers, A. W.
name: Stubbs, C. W.
name: Sutherland, W.
name: Welch, D. L.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The MACHO Project is searching for galactic dark matter in the form of massive compact halo objects (Machos). Millions of stars in the Large Magellanic Cloud (LMC), Small Magellanic Cloud (SMC), and Galactic bulge are photometrically monitored in an attempt to detect rare gravitational microlensing events caused by otherwise invisible Machos. Analysis of two years of photometry on 8.5 million stars in the LMC reveals 8 candidate microlensing events, far more than the $\sim1$ event expected from lensing by low-mass stars in known galactic populations. From these eight events we estimate the optical depth towards the LMC from events with $2 < \that < 200$ days to be $τ_2^{200} \approx 2.9 ^{+1.4}_{-0.9} \ten{-7}$. This exceeds the optical depth of $0.5\ten{-7}$ expected from known stars and is to be compared with an optical depth of $4.7\ten{-7}$ predicted for a ``standard'' halo composed entirely of Machos. The total mass in this lensing population is $\approx 2^{+1.2}_{-0.7} \ten{11} \msun$ (within 50 kpc from the Galactic center). Event timescales yield a most probable Macho mass of $0.5^{+0.3}_{-0.2}\msun$, although this value is quite model dependent.
description: 10 pages, 6 epsf figures and style file included, 451k, also at http://wwwmacho.mcmaster.ca/Pubs/Pubs.html; To appear in the Proceedings of "Sources and Detection of Dark Matter in the Universe", Santa Monica, CA, Feb., 1996
Viral infection model with diffusion and state-dependent delay: stability of classical solutions
Creators: name: Rezounenko, Alexander
Publisher: name: arXiv
Year: 2017
Subjects: subject: Dynamical Systems (math.DS)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 93C23, 34K20, 35K57, 97M60

description: A class of reaction-diffusion virus dynamics models with intracellular state-dependent delay and a general non-linear infection rate functional response is investigated. We are interested in classical solutions with Lipschitz in-time initial functions which are adequate to the discontinuous change of parameters due to, for example, drug administration. The Lyapunov functions technique is used to analyse stability of interior infection equilibria which describe the cases of a chronic disease.
description: 17 pages
Intervenção em pessoas com demência e cuidadores: Café Memória um espaço privilegiado de relação
Creators: name: Amante, Maria João
name: Alvarez, Catarina
name: Araújo, Lia
name: Sousa, Isabel
Publisher: name: Millenium - Journal of Education, Technologies, and Health
Year: 2017

description: Introdução: o Café Memória assume-se como uma estratégia inovadora em vários países da Europa e nos USA. Trata-se de um encontro com periodicidade mensal, realizado em ambiente informal e comunitário, destinado a pessoas com problemas de memória ou demência, aos seus familiares e cuidadores e outras pessoas interessadas nesta problemática. Objetivo: o presente estudo procura apresentar evidências sobre este tipo de abordagem. Métodos: foram recolhidos dados de caracterização dos participantes em 12 Cafés Memória de Portugal e, em apenas num dos Cafés do projeto, das mais-valias emergentes da participação nestas sessões. Resultados: ao longo dos últimos 3 anos, foram desenvolvidas 268 sessões que contaram com 322 voluntários, 566 convidados e 1500 participantes, tendo estes últimos avaliado as sessões que frequentaram muito positivamente. As categorias que emergiram da análise de conteúdo da informação recolhida com participantes e voluntários (n = 30) apontam para valorização das relações interpessoais (86.7%); seguem-se os benefícios ao nível do bem-estar (76.7%) e das aprendizagens (56.7%). Conclusões: os resultados apontam para a importância das relações e contactos sociais, ainda pouco valorizadas nas intervenções não-farmacológicas com estes doentes e cuidadores.
description: Millenium - Journal of Education, Technologies, and Health, Series 2, no. 2e: special edition: june 2017
Bezlotoxumab: A Review in Preventing Clostridium Difficile Infection Recurrence
Creators: name: Deeks, Emma D
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine

description: Compliance with Ethical Standards Funding: The preparation of this review was not supported by any external funding. Conflicts of interest: Emma Deeks is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here. Abstract Bezlotoxumab (Zinplava™) is a fully human monoclonal antibody against Clostridium difficile toxin B indicated for the prevention of C. difficile infection (CDI) recurrence in patients with a high recurrence risk. It is the first agent approved for recurrence prevention and is administered as a single intravenous infusion in conjunction with standard-of-care (SoC) antibacterial treatment for CDI. In well-designed, placebo-controlled, phase 3 trials (MODIFY 1 and 2), a single infusion of bezlotoxumab, given in combination with SoC antibacterial therapy for CDI in adults, was effective in reducing CDI recurrence in the 12 weeks post-treatment, with this benefit being seen mainly in the patients at high recurrence risk. Bezlotoxumab did not impact the efficacy of the antibacterials being used to treat the CDI and, consistent with its benefits on CDI recurrence, appeared to reduce the need for subsequent antibacterials, thus minimizing further gut microbiota disruption. Longer term, there were no further CDI recurrences over 12 months’ follow-up among patients who had received bezlotoxumab in MODIFY 2 and entered an extension substudy. Bezlotoxumab has low immunogenicity and is generally well tolerated, although the potential for heart failure in some patients requires consideration; cost-effectiveness data for bezlotoxumab are awaited with interest. Thus, a single intravenous infusion of bezlotoxumab during SoC antibacterial treatment for CDI is an emerging option for reducing CDI recurrence in adults at high risk of recurrence. Access to the full article can be found here. © Springer International Publishing AG, part of Springer Nature 2017