cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enlarging Effective DRAM Capacity through Hermes
Creators: name: Logan, Luke
name: Kougkas, Anthony
name: Sun, Xian-He
Publisher: name: Zenodo
Year: 2024

description: Traditionally, memory and I/O substrates have been considered separate entities due to their differences in terms of performance and persistence. However, modern data-intensive memory-centric workloads widespread in HPC are challenging these distinctions. Data analytics, machine learning, and deep learning codes perform large-scale computations on data which greatly exceed the bounds of memory, relying on explicit data movements to I/O systems to meet basic capacity requirements. This often leads to significantly increased development complexity and suboptimal, one-off solutions where I/O and compute happen in distinct, synchronous phases, incurring the memory wall problem in the compute phase and the notorious I/O bottleneck during the I/O phase. Conversely, scientific simulation codes are becoming increasingly memory-intensive and are developed assuming large memory capacities are provided to avoid out-of-core development complexity. To reduce complexity and I/O costs, HPC and Cloud sites have been increasing DRAM capacities. However, while many applications desire an effectively infinite memory to generate and analyze massive datasets, the ever-increasing size of data and the extreme financial and energy costs of DRAM make scaling DRAM capacity unsustainable.

In this work, we expose the Hermes I/O buffering system as a software distributed shared memory (DSM) that enlarges effective memory capacity through intelligent tiered DRAM and storage management. This DSM provides workload-aware data organization, eviction, and prefetching policies to reduce DRAM consumption while ensuring speedy access to critical data. Evaluations show that various workloads can be executed with a fraction of the DRAM while offering competitive performance.
Hermes: A Multi-Tiered Distributed I/O Buffering System
Creators: name: Logan, Luke
name: Kougkas, Anthony
name: Sun, Xian-He
Publisher: name: Zenodo
Year: 2024

description: Modern High-Performance Computing (HPC) systems are adding extra layers to the memory and storage hierarchy, named deep memory and storage hierarchy (DMSH), to increase I/O performance. New hardware technologies, such as NVMe and SSD, have been introduced in burst buffer installations to reduce the pressure for external storage and boost the burstiness of modern I/O systems. DMSH has demonstrated its strength and potential in practice. However, each layer of DMSH is an independent heterogeneous system and data movement among more layers is significantly more complex even without considering heterogeneity. How to efficiently utilize the DMSH is a subject of research facing the HPC community. In this paper, we present the design and implementation of Hermes: a new, heterogeneous-aware, multi-tiered, dynamic, and distributed I/O buffering system. Hermes enables, manages, supervises, and, in some sense, extends I/O buffering to fully integrate into the DMSH. We introduce three novel data placement policies to efficiently utilize all layers and we present three novel techniques to perform memory, metadata, and communication management in hierarchical buffering systems. Our evaluation shows that, in addition to automatic data movement through the hierarchy, Hermes can significantly accelerate I/O and outperforms by more than 2x state-of-the-art buffering platforms.
Growth of degrees of integrable mappings
Creators: name: Van Der Kamp, Pieter
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 49
subject: Mathematical sciences
classificationCode: 4901
subject: Applied mathematics
classificationCode: 4903
subject: Numerical and computational mathematics
classificationCode: 4904
subject: Pure mathematics

description: We study mappings obtained as s-periodic reductions of the lattice Korteweg-de Vries equation. For small, s ∈ℕ 2we establish upper bounds on the growth of the degree of the numerator of their iterates. These upper bounds appear to be exact. Moreover, we conjecture that for any s 1, s 2 that are co-prime, the growth is, ~(2s 1s 2) -1 n 2except when, s 1+s 2=4 where the growth is linear ~n. Also, we conjecture the degree of the nth iterate in projective space to be ~(s 1+s 2)(2s 1s 2) -1 n 2.
Update on Cloud Optimized HDF5 Files
Creators: name: Jelenak, Aleksandar
Publisher: name: Zenodo
Year: 2024

description: Ever since introducing the concept of cloud optimized HDF5 files (COH5) users were interested about specific storage settings for these files and their impact on performance. This talk will provide some answers to such questions based on the work with NASA stakeholders and their satellite HDF5 data.
Description of Scurvy Symptoms by Olaus Magnus (1555)
Creators: name: Hemilä, Harri
name: Korkiakangas, Timo
name: Chalker, Elizabeth
Publisher: name: Zenodo
Year: 2024
Subjects: Scurvy
Vitamin C
Ascorbic acid
Olaus Magnus

description: An early description of “land scurvy” was by Olaus Magnus, a Swedish writer and Catholic clergyman (1490-1557). He wrote an 800-page book about life in the Nordic countries which was published in 1555.

Two sections in the book describe symptoms which are consistent with scurvy. Olaus Magnus wrote in Latin and this document contains the English and Finnish translations of the two sections.
Growth of degrees of integrable mappings
Creators: name: Van Der Kamp, Pieter
Publisher: name: La Trobe
Year: 2022

description: We study mappings obtained as s-periodic reductions of the lattice Korteweg-de Vries equation. For small, s ∈ℕ 2we establish upper bounds on the growth of the degree of the numerator of their iterates. These upper bounds appear to be exact. Moreover, we conjecture that for any s 1, s 2 that are co-prime, the growth is, ~(2s 1s 2) -1 n 2except when, s 1+s 2=4 where the growth is linear ~n. Also, we conjecture the degree of the nth iterate in projective space to be ~(s 1+s 2)(2s 1s 2) -1 n 2.
Sports officials' intention to continue
Creators: name: Cuskelly, G
name: Hoye, Russell
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 35
subject: Commerce, management, tourism and services
classificationCode: 3504
subject: Commercial services
classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business
classificationCode: 3507
subject: Strategy, management and organisational behaviour

description: No description supplied
Emphysematous pyelonephritis in a solitary kidney
Creators: name: Tonolini, Massimo
Publisher: name: EURORAD
Year: 2016
Subjects: subject: Kidney
subject: Urinary Tract / Bladder
subject: CT
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Infection

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 55 years
description: Clinical History: Middle-aged male admitted to emergency department with high fever, dysuria, distended tender abdomen without peritonism. Laboratory studies including arterial blood gases revealed severe renal impairment (7.5 mg/dl serum creatinine), markedly increa... Final Diagnosis: Emphysematous pyelonephritis. Congenital hypoplasia of contralateral kidney.
The 'Lubra' type in Australian imaginings of the aboriginal woman from 1836-1973
Creators: name: Conor, Liz
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 43
subject: History, heritage and archaeology
classificationCode: 4303
subject: Historical studies
classificationCode: 44
subject: Human society
classificationCode: 4405
subject: Gender studies

description: No description supplied
Optimizing molecular dynamics AI model using HDF5 and DYAD
Creators: name: Devarajan, Hariharan
Publisher: name: Zenodo
Year: 2024

description: The Massively Parallel Multiscale Machine-Learned Modeling Infrastructure (MuMMI) is a framework designed to execute multiscale modeling simulations of large molecular systems integrated through ML techniques. The DL training portion of the MuMMI workflow uses NPZ arrays that lead to inefficient data loading characteristics such as I/O inefficiency, sample distribution, and sample coverage. In this talk, we will discuss our initial experience with integrating HDF5 and DYAD to improve the data access behavior of the training and improve sample distribution and sample coverage for the DL training. This talk will focus on three main directions. First, the challenges and experience of moving workloads towards HDF5. Second, features that would assist in adapting HDF5 for optimizing DL training. Finally, our experience in integrating the DYAD solution for optimizing I/O with HDF5 for this DL workload. In conclusion, we will demonstrate that we accelerated the MuMMI workflow using DYAD and HDF5 on the Corona cluster at LLNL.
On the Fourier transform of the greatest common divisor
Creators: name: Van Der Kamp, Pieter
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 4904
subject: Pure mathematics

description: The discrete Fourier transform of the greatest common divisor (formula presented) with αm a primitive m-th root of unity, is a multiplicative function that generalizes both the gcd-sum function and Euler's totient function. On the one hand it is the Dirichlet convolution of the identity with Ramanujan's sum, id[a] = id * c•(a), and on the other hand it can be written as a generalized convolution product, id[a] = id *a φ. We show that id[a](m) counts the number of elements in the set of ordered pairs (i, j) such that i · j ≡ a mod m. Furthermore we generalize a dozen known identities for the totient function, to identities which involve the discrete Fourier transform of the greatest common divisor, including its partial sums, and its Lambert series.
Acne At The Bottom Of The Main Sequence
Creators: name: Barnes, John
name: Haswell, C.
name: Jenkins, J.
name: Jeffers, S.
name: Jones, H. R. A.
name: Lohr, M.
name: Pavlenko, Y.
Publisher: name: Zenodo
Year: 2016

description: Starspots are an important manifestation of stellar activity and yet their distribution patterns on the lowest mass stars is not well known. Time series spectra of fully convective M dwarfs taken in the red-optical with UVES reveal numerous line profile distortions which are interpreted as starspots. We derive Doppler images for four M4.5V - M9V stars and find that contrast ratios corresponding to photosphere-spot temperature differences of only 200-300 K are sufficient to model the timeseries spectra. Although more starspot structure is found at high latitudes, spots are reconstructed at a range of phases and latitudes with mean spot filling factors of only a few per cent. The occurrence of low-contrast spots at predominantly high latitudes is in general likely to be responsible for the low amplitude photometric variability seen in late-M dwarfs. The recovered starspot patterns are used to assess their effect on precision radial velocity surveys aimed at detecting planets around this population of stars.
description: Contributed talk at the Splinter Session on "Variability of Solar/Stellar Magnetic Activity" (http://coolstars19.com/splinters/stellar-var/index.html) at the "Cool Stars 19" Workshop
The content of the trust: what must a trustee be obliged to do with the property?
Creators: name: Barkley, Tobias
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 48
subject: Law and legal studies
classificationCode: 4803
subject: International and comparative law
classificationCode: 4806
subject: Private law and civil obligations

description: No description supplied
Proceedings Of The Southern African Wildlife Management Association Symposium 2016. Sustainable Wildlife Management: Striking A Balance?
Creators: name: Southern African Wildlife Management Association
Publisher: name: Zenodo
Year: 2016
Subjects: Wildlife management
Southern Africa

description: Proceedings of the Southern African Wildlife Management Association symposium 2016. Sustainable Wildlife Management: Striking a Balance? Tzaneen, 19-21 September 2016.
LA POETA Y EL SILENCIO: DESAFÍOS EN LA TRADUCCIÓN DE ALEJANDRA PIZARNIK
Creators: name: Kanjere, Anastasia
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: https://www.jstor.org/stable/43803266?seq=1#metadata_info_tab_contents Title in English: The poet and the silence: Challenges in the translation of Alejandra Pizarnik
Uncharted Territory - Exploring New Frontiers for HDF5 (Keynote)
Creators: name: Koziol, Quincey
Publisher: name: Zenodo
Year: 2024

description: Blast-off: GPU Accelerated HDF5The industry's shift to accelerated computing has moved the goal posts for accessing application data, and provided dramatically faster compute resources for HDF5 transforms. This talk describes a path to directly accessing GPU memory for data access operations and moving HDF5 data transforms from the host to the GPU.

We're Breaking Up! Disaggregated HDF5 Containers on Object Storage SystemsObject storage systems dominate cloud computing and are making significant inroads into the on-premise storage deployments as well. This talk describes storing HDF5 containers (files, today) natively on object storage systems in high-performance and portable way. Disaggregating HDF5 metadata from application data and storing it in a lightweight database, e.g. SQLite, provides improvements to performance and resiliency, and adds query capabilities that are expensive with today's native file format. Sharding application data into multiple objects enables greater parallelism and performance as well, especially with cloud object stores.

Not for Spotify: Streaming HDF5 DataHDF5 is ubiquitous across science domains, but has typically targeted array-like access patterns. Streaming data from cameras, particle accelerators, and other high-speed data sources into HDF5 files is also common. This talk presents new HDF5 APIs and format extensions that are tailored to this use case and maximize performance for both writing and reading data in a streamed fashion.
From Noordwijkerhout to Bendigo: lessons learnt in developing a high-risk foot clinic in regional Australia
Creators: name: Perrin, Byron
name: Gardner, Marcus
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: In 2003 a podiatrist from Bendigo Health attended the 4th International
Symposium of the Diabetic Foot in Noorwijkerhout, the Netherlands. Since
 then the regionally-based, outpatient, multi-disciplinary Diabetic Foot
 Clinic (DFC) was developed.
From Noordwijkerhout to Bendigo: lessons learnt in developing a high-risk foot clinic in regional Australia
Creators: name: Perrin, Byron
name: Gardner, M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: In 2003 a podiatrist from Bendigo Health attended the 4th International Symposium of the Diabetic Foot in Noorwijkerhout, the Netherlands. Since then the regionally-based, outpatient, multi-disciplinary Diabetic Foot Clinic (DFC) was developed.
Australian Gay and Bisexual Men's Attitudes to HIV Treatment as Prevention in Repeated, National Surveys, 2011-2013
Creators: name: Holt, M
name: Lea, Toby
name: Murphy, Dean
name: Ellard, Jeanne
name: Rosengarten, M
name: Kippax, SC
name: De Wit, JBF
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4206
subject: Public health

description: Abstract: Objective: Assess the acceptability of HIV treatment as prevention and early antiretroviral treatment among gay and bisexual men in Australia and any changes in attitudes over time. Methods: National, online, cross-sectional surveys of gay and bisexual men were repeated in 2011 and 2013. Changes in attitudes to HIV treatment over time were assessed with multivariate analysis of variance. The characteristics of men who agreed that HIV treatment prevented transmission and thought that early treatment was necessary were identified with multivariate logistic regression. Results: In total, 2599 HIV-negative, untested and HIV-positive men participated (n = 1283 in 2011 and n = 1316 in 2013). Attitudes changed little between 2011 and 2013; most participants remained sceptical about the preventative benefits of HIV treatment. In 2013, only 2.6% of men agreed that HIV treatment prevented transmission; agreement was associated with being HIV-positive, having an HIV-positive regular partner, and having received HIV post-exposure prophylaxis. In contrast, 71.8% agreed that early antiretroviral treatment is necessary; younger men were more likely and HIV-positive men and participants with HIV-positive partners were much less likely to agree with this. Conclusions: Promoting the individual health benefits of HIV treatment rather than its preventative benefits remains more acceptable to Australian gay and bisexual men.
The impact of course title and instructor gender on student perceptions and interest in a women's and gender studies course
Creators: name: Spoor, Jennifer
name: Lehmiller, JJ
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Diversity awareness has enormous benefits, and universities in the United States increasingly require students to complete diversity-related courses. Prior research has demonstrated that students' initial attitudes toward these courses affect their subsequent engagement, as well as the quality of their learning experience; however, very little research has examined how these initial attitudes are formed. We conducted an experiment to examine this issue in the context of a women's and gender studies course in psychology. Participants read one of two identical course descriptions that varied only the course title (i.e., Psychology of Gender versus Psychology of Women) and instructor gender. Participants perceived a women-titled course to be narrowly focused compared to an identical gender-titled course and were more interested in taking the gender-titled course. Instructor gender had no effects on any of the variables. Additionally, female participants had more positive attitudes toward the course than male participants, regardless of title. Exploratory mediation analyses indicated that the main effects of course title and participant gender were mediated by perceptions of course content. Implications for improving student experiences and interest in diversity-related courses are discussed. Copyright:
Professionalism, the Public Interest, and Social Accounting
Creators: name: Boyce, Gordon
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2014 Springer Science+Business Media Dordrecht.
The tendency towards self-interest and an increasingly commercial orientation in accounting, together with a string of business and accounting scandals, brings the professional status of accounting into question. This chapter explores the how a renewed sense of professionalism within accounting may lead to greater recognition of the social within accounting. Positioned at the margins of accounting, social accounting includes emergent technologies of social accounting, focusing on silent, shadow, and counter accounting that expose values and priorities, challenge accepted understandings, generate new visibilities, and highlight the perspectives of neglected and marginalised segments of society. In so doing, social accounting may provide an important means for addressing the public interest agenda in accounting, and for strengthening the relationship between accounting and the public interest.
Intuition, metacognition, and philosophical inquiry
Creators: name: Egler, Miguel
Publisher: name: The University of St Andrews
Year: 2019
Subjects: Intuition
Philosophical inquiry
Experimental philosophy
Philosophical methodology
Expertise
Feeling of rightness
Contrastivism

description: This thesis examines whether appeals to intuition provide warrant for philosophical positions and claims. Recent empirical studies suggest that people’s intuitions are sensitive to a host of epistemically irrelevant factors. Some philosophers (Critics) take these findings to motivate scepticism about the traditional methodology of philosophy, which is often taken to rely on intuitions. In reply, others (Defenders) have argued that these empirical studies fail to support any such methodological worries. One type of argument given by Defenders is that empirical studies about intuitions are simply irrelevant for assessing the methodology of philosophy. A second type of argument is that empirical studies need to be refined before they can be fruitfully used in debates about the methodology of philosophy: for instance, some Defenders have suggested that empirical studies must account for the distinctive phenomenology of intuitions; whereas others have argued that these studies should focus exclusively on the intuitions of philosophers—which, they claim, are not prone to the deleterious effects found to afflict the intuitions of non-philosophers. In this thesis, I argue that the most prominent arguments both for and against scepticism about the methodology of philosophy are problematic. I defend instead a moderate position according to which intuitions can warrant philosophical positions and claims, but that philosophers should engage with findings in cognitive psychology in order to make better informed assessments of when to trust their intuitions, and when to refrain from relying on them in inquiry. In chapter 1, I argue that empirical findings about intuitions are indeed relevant for assessments of the traditional methodology of philosophy. In chapter 2, I appeal to recent work in cognitive psychology on the feeling of rightness to argue that a phenomenological conception of intuition does not insulate philosophical methodology from the relevant empirical concerns. In chapter 3, I argue that philosophical training can in some cases give rise to a kind of expertise that shields philosophers from the deleterious effects of biases on their intuitions; but, I contend that further empirical studies are required to establish what those cases are. And against Critics, I argue in chapter 4 that even if intuitions show marked variation with respect to epistemically irrelevant factors, this does not entail that we should be sceptical about their use in philosophical inquiry. Lastly, in chapter 5 I explore the proposal that intuitions provide warrant for philosophical positions and claims because they enable understanding of why their contents are true.
Risk of death or hospital admission among community-dwelling older adults living with dementia in Australia
Creators: name: You, EC
name: Dunt, DR
name: White, Vanessa
name: Hoorn, S Vander
name: Doyle, C
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Older people living with dementia prefer to stay at home to receive support. But they are at high risk of death and/or hospital admissions. This study primarily aimed to determine risk factors for time to death or hospital admission (combined) in a sample of community-dwelling older people living with dementia in Australia. As a secondary study purpose, risk factors for time to death were also examined. Methods. This study used the data of a previous project which had been implemented during September 2007 and February 2009. The original project had recruited 354 eligible clients (aged 70 and over, and living with dementia) for Extended Aged Care At home Dementia program services during September 2007 and 2008. Client information and carer stress had been collected from their case managers through a baseline survey and three-monthly follow-up surveys (up to four in total). The principal data collection tools included Global Deterioration Scale, Modified Barthel Index, Instrumental-Dependency OARS, Adapted Cohen-Mansfield Agitation Inventory, as well as measures of clients' socio-demographic characteristics, service use and diseases diagnoses. The sample of our study included 284 clients with at least one follow-up survey. The outcome variable was death or hospital admission, and death during six, nine and 16-month study periods. Stepwise backwards multivariate Cox proportional hazards analysis was employed, and Kaplan-Meier survival analysis using censored data was displayed. Results: Having previous hospital admissions was a consistent risk factor for time to death or hospital admission (six-month: HR = 3.12; nine-month: HR = 2.80; 16-month: HR = 2.93) and for time to death (six-month: HR = 2.27; 16-month: HR = 2.12) over time. Previously worse cognitive status was a consistent risk factor over time (six- and nine-month: HR = 0.58; 16-month: HR = 0.65), but no previous use of community care was only a short-term risk factor (six-month: HR = 0.42) for time to death or hospital admission. Conclusions: Previous hospital admissions and previously worse cognitive status are target intervention areas for reducing dementia clients' risk of time to death or hospital admission, and/or death. Having previous use of community care as a short-term protective factor for dementia clients' time to death or hospital admission is noteworthy. © 2014 You et al.; licensee BioMed Central Ltd.
Passenger list for the Empress of Canada's 12 May 1938 sailing to Honolulu
Creators: name: Canadian Pacific Steamships
name: De Laval, John
Publisher: name: The University of British Columbia
Year: 2018

description: Passenger list typed on several sheets of paper. Assembled by John de Laval, storekeeper and steward on the Empress of Asia and deck steward on the first Empress of Canada.
Research methodologies represented (or not) in AJEE
Creators: name: Gough, Noel
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: As one of the contributors to the first issue of the Australian Journal of Environmental Education (AJEE) in 1984 (and to a further seven issues between 1991 and 2009), and as a sometime member of its editorial board (1991–1994) and the editorial collective that edited four issues (1999–2002), I have been privileged to witness at close hand its development from infancy to maturity. My particular focus in this brief reflection on the journal's development is on the research methodologies that it has privileged or diminished. In the interests of brevity, I focus in detail only on some tendencies that emerged in the first few issues, with the remainder being dealt with via selective references and impressions.
Building research capacity in a regional Australian health service: a management strategy analysis
Creators: name: Murphy, Kylie
name: Stockton, D
name: Kolbe, A
name: Chambers, AL Hulme
name: Smythe, G
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health
classificationCode: 4407
subject: Policy and administration

description: Research capacity building (RCB) can be challenging for health services, especially in non-metropolitan areas. This management analysis documents the RCB strategy recently initiated by Albury Wodonga Health (AWH), a large health service in regional Australia. AWH’s strategy addresses three steps believed to be crucial in planning effective RCB: an initial needs assessment, identification of clear success indicators and multi-level structural considerations. In particular, AWH’s strategy is based on current evidence pointing to the importance of external partnerships, the need for whole-of-organisation leadership, and the need to involve appropriate personnel. Early achievements of AWH’s strategy include Executive-endorsed organisational research priorities, wide awareness of RCB as a whole-of organisation goal, agreed protocols for initiating and reviewing research proposals, formalised university partnerships, the establishment of a vibrant Research Interest Group, a number of current and planned collaborative projects, improved communication about research activities within AWH, and a program logic and evaluation framework to assist in maintaining focus and assessing the effectiveness of the strategy over the longer term. AWH’s RCB strategy may serve as a modifiable model for managers of other similar health services pursuing a stronger research culture.
Initial value problems for quad equations
Creators: name: Van Der Kamp, Pieter
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 49
subject: Mathematical sciences
classificationCode: 4901
subject: Applied mathematics
classificationCode: 490105
subject: Dynamical systems in applications
classificationCode: 4904
subject: Pure mathematics
classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: We describe a method to construct well-posed initial value problems (IVPs) for not necessarily integrable equations on not necessarily simply connected quad-graphs. Although the method does not always provide a well-posed IVP (not all quad-graphs admit well-posed IVPs) it is effective in the class of rhombic embeddable quad-graphs.
Initial value problems for quad equations
Creators: name: Van Der Kamp, Pieter
Publisher: name: La Trobe
Year: 2022

description: We describe a method to construct well-posed initial value problems (IVPs) for not necessarily integrable equations on not necessarily simply connected quad-graphs. Although the method does not always provide a well-posed IVP (not all quad-graphs admit well-posed IVPs) it is effective in the class of rhombic embeddable quad-graphs.
Bioorganic fertilizer enhances soil suppressive capacity against bacterial wilt of tomato
Creators: name: L Liu
name: C Sun
name: S Liu
name: R Chai
name: W Huang
name: X Liu
name: Caixian Tang
name: Y Zhang
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2015 Liu et al. Tomato bacterial wilt caused by Ralstonia solanacearum is one of the most destructive soilborne diseases. Many strategies have been taken to improve soil suppressiveness against this destructive disease, but limited success has been achieved. In this study, a novel bioorganic fertilizer revealed a higher suppressive ability against bacterial wilt compared with several soil management methods in the field over four growing seasons from March 2011 to July 2013. The application of the bioorganic fertilizer significantly (P<0.05) reduced disease incidence of tomato and increased fruit yields in four independent trials. The association among the level of disease incidence, soil physicochemical and biological properties was investigated. The soil treated with the bioorganic fertilizer increased soil pH value, electric conductivity, organic carbon, NH4+-N, NO3--N and available K content, microbial activities and microbial biomass carbon content, which were positively related with soil suppressiveness. Bacterial and actinomycete populations assessed using classical plate counts were highest, whereas R. solanacearum and fungal populations were lowest in soil applied with the bioorganic fertilizer. Microbial community diversity and richness were assessed using denaturing gel gradient electrophoresis profile analysis. The soil treated with the bioorganic fertilizer exhibited higher bacterial community diversity but lower fungal community diversity. Redundancy analysis showed that bacterial community diversity and richness negatively related with bacterial wilt suppressiveness, while fungal community richness positively correlated with R. solanacearum population. We concluded that the alteration of soil physicochemical and biological properties in soil treated with the bioorganic fertilizer induced the soil suppressiveness against tomato bacterial wilt.
Introduction of Non-Native Pollinators Can Lead to Trans-Continental Movement of Bee-Associated Fungi
Creators: name: Hedtke, Shannon
name: Blitzer, EJ
name: Montgomery, GA
name: Danforth, BN
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3004
subject: Crop and pasture production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3103
subject: Ecology
classificationCode: 3107
subject: Microbiology

description: Bees are essential pollinators for many flowering plants, including agriculturally important crops such as apple. As geographic ranges of bees or their host plants change as a result of human activities, we need to identify pathogens that could be transmitted among newly sympatric species to evaluate and anticipate their effects on bee communities. We used PCR screening and DNA sequencing to evaluate exposure to potentially disease-causing microorganisms in a pollinator of apple, the horned mason bee (Osmia cornifrons). We did not detect microsporidia, Wolbachia, or trypanosomes, which are common pathogens of bees, in any of the hundreds of mason bees screened. We did detect both pathogenic and apathogenic (saprophytic) fungal species in the genus Ascosphaera (chalkbrood), an unidentified species of Aspergillus fungus, and a strain of bacteria in the genus Paenibacillus that is probably apathogenic. We detected pathogenic fungal strains in asymptomatic adult bees that therefore may be carriers of disease. We demonstrate that fungi from the genus Ascosphaera have been transported to North America along with the bee from its native range in Japan, and that O. cornifrons is exposed to fungi previously only identified from nests of other related bee species. Further study will be required to quantify pathogenicity and health effects of these different microbial species on O. cornifrons and on closelyrelated native North American mason bees that may now be exposed to novel pathogens. A global perspective is required for pathogen research as geographic ranges of insects and microorganisms shift due to intentional or accidental introductions. Copyright:
Performing ethnocultural identity on the Sinophone Internet: testing the limits of minzu
Creators: name: Leibold, James
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 44
subject: Human society
classificationCode: 4408
subject: Political science
subject: FOS: Political science
classificationCode: 440807
subject: Government and politics of Asia and the Pacific
classificationCode: 4410
subject: Sociology
subject: FOS: Sociology

description: This article explores what happens to the Chinese Party-state’s notion of minzu (nationality, ethnicity or ethno-national identity) in the vastness of cyberspace. The idea that the People’s Republic of China (PRC) comprises 56 distinct yet united minzu groups has encapsulated and circumscribed the performance of ethnocultural diversity in mainland China over the last 60 plus years. In this article, I seek to demonstrate how the Internet helps to loosen the Party-state’s grip on ‘Chineseness’ and its related categories of identity, opening up new spaces for the articulation of a wide range of ethnocultural subject positions that both self-define, mediate and, at times, even transcended minzu-ness. At the same time, however, the fractured and transitory nature of these online congregations renders them largely inconsequential when faced with a powerful and authoritarian Party-state and its robust regime of minzu classification and minzu-based policies inside the PRC.
BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila
Creators: name: Doggett, K
name: Turkel, N
name: Willoughby, LF
name: Ellul, J
name: Murray, MJ
name: Richardson, Helena
name: Brumby, AM
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis
classificationCode: 321103
subject: Cancer genetics

description: During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties. To gain a greater understanding of how these properties are interlinked in cancers we used Drosophila epithelial tumor models, which are driven by orthologues of human oncogenes (activated alleles of Ras and Notch) in cooperation with the loss of the cell polarity regulator, scribbled (scrib). Within these tumors, both invasive, mesenchymal-like cell morphology and continual tumor overgrowth, are dependent upon Jun N-terminal kinase (JNK) activity. To identify JNK-dependent changes within the tumors we used a comparative microarray analysis to define a JNK gene signature common to both Ras and Notch-driven tumors. Amongst the JNK-dependent changes was a significant enrichment for BTB-Zinc Finger (ZF) domain genes, including chronologically inappropriate morphogenesis (chinmo). chinmo was upregulated by JNK within the tumors, and overexpression of chinmo with either RasV12 or Nintra was sufficient to promote JNK-independent epithelial tumor formation in the eye/antennal disc, and, in cooperation with RasV12, promote tumor formation in the adult midgut epithelium. Chinmo primes cells for oncogene-mediated transformation through blocking differentiation in the eye disc, and promoting an escargot-expressing stem or enteroblast cell state in the adult midgut. BTB-ZF genes are also required for Ras and Notch-driven overgrowth of scrib mutant tissue, since, although loss of chinmo alone did not significantly impede tumor development, when loss of chinmo was combined with loss of a functionally related BTB-ZF gene, abrupt, tumor overgrowth was significantly reduced. abrupt is not a JNK-induced gene, however, Abrupt is present in JNK-positive tumor cells, consistent with a JNK-associated oncogenic role. As some mammalian BTB-ZF proteins are also highly oncogenic, our work suggests that EMT-promoting signals in human cancers could similarly utilize networks of these proteins to promote cancer stem cell states. Copyright:
Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor
Creators: name: Portela-Esteban, Marta
name: Parsons, LM
name: Grzeschik, NA
name: Richardson, Helena
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 321103
subject: Cancer genetics

description: The evolutionarily conserved neoplastic tumor suppressor protein, Lethal (2) giant larvae (Lgl), plays roles in cell polarity and tissue growth via regulation of the Hippo pathway. In our recent study, we showed that in the developing Drosophila eye epithelium, depletion of Lgl leads to increased ligand-dependent Notch signaling. lgl mutant tissue also exhibits an accumulation of early endosomes, recycling endosomes, early-multivesicular body markers and acidic vesicles. We showed that elevated Notch signaling in lgl− tissue can be rescued by feeding larvae the vesicle de-acidifying drug chloroquine, revealing that Lgl attenuates Notch signaling by limiting vesicle acidification. Strikingly, chloroquine also rescued the lgl− overgrowth phenotype, suggesting that the Hippo pathway defects were also rescued. In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis.
Impact of an Ivermectin Mass Drug Administration on Scabies Prevalence in a Remote Australian Aboriginal Community
Creators: name: Kearns, TM
name: Speare, R
name: Cheng, AC
name: McCarthy, J
name: Carapetis, JR
name: Holt, DC
name: Currie, BJ
name: Page, W
name: Shield, Jennifer
name: Gundjirryirr, R
name: Bundhala, L
name: Mulholland, E
name: Chatfield, M
name: Andrews, RM
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Scabies is endemic in many Aboriginal and Torres Strait Islander communities, with 69% of infants infected in the first year of life. We report the outcomes against scabies of two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community. Methods: Utilizing a before and after study design, we measured scabies prevalence through population census with sequential MDAs at baseline and month 12. Surveys at months 6 and 18 determined disease acquisition and treatment failures. Scabies infestations were diagnosed clinically with additional laboratory investigations for crusted scabies. Non-pregnant participants weighing ≥15 kg were administered a single 200 μg/kg ivermectin dose, repeated after 2–3 weeks if scabies was diagnosed, others followed a standard alternative algorithm. Principal Findings: We saw >1000 participants at each population census. Scabies prevalence fell from 4% at baseline to 1% at month 6. Prevalence rose to 9% at month 12 amongst the baseline cohort in association with an identified exposure to a presumptive crusted scabies case with a higher prevalence of 14% amongst new entries to the cohort. At month 18, scabies prevalence fell to 2%. Scabies acquisitions six months after each MDA were 1% and 2% whilst treatment failures were 6% and 5% respectively. Conclusion: Scabies prevalence reduced in the six months after each MDA with a low risk of acquisition (1–2%). However, in a setting where living conditions are conducive to high scabies transmissibility, exposure to presumptive crusted scabies and population mobility, a sustained reduction in prevalence was not achieved. Clinical Trial Registration: Australian New Zealand Clinical Trial Register (ACTRN—12609000654257).
The burkholderia pseudomallei proteins BapA and BapC Are Secreted TTSS3 Effectors and BapB levels modulate expression of BopE
Creators: name: P Treerat
name: P Alwis
name: T D'Cruze
name: Meabh Cullinane
name: J Vadivelu
name: RJ Devenish
name: M Prescott
name: B Adler
name: JD Boyce
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2015 Treerat et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many Gram-negative pathogens use a type III secretion system (TTSS) for the injection of bacterial effector proteins into host cells. The injected effector proteins play direct roles in modulation of host cell pathways for bacterial benefit. Burkholderia pseudomallei, the causative agent of melioidosis, expresses three different TTSSs. One of these systems, the TTSS3, is essential for escape from host endosomes and therefore intracellular survival and replication. Here we have characterized three putative TTSS3 proteins; namely BapA, BapB and BapC. By employing a tetracysteine (TC)-FlAsHlabelling technique to monitor the secretion of TC-Tagged fusion proteins, BapA and BapC were shown to be secreted during in vitro growth in a TTSS3-dependant manner, suggesting a role as TTSS3 effectors. Furthermore, we constructed B. pseudomallei bapA, bapB and bapC mutants and used the well-characterized TTSS3 effector BopE as a marker of secretion to show that BapA, BapB and BapC are not essential for the secretion process. However, BopE transcription and secretion were significantly increased in the bapB mutant, suggesting that BapB levels modulate BopE expression. In a BALB/c mouse model of acute melioidosis, the bapA, bapB and bapC mutants showed a minor reduction of in vivo fitness. Thus, this study defines BapA and BapC as novel TTSS3 effectors, BapB as a regulator of BopE production, and all three as necessary for full B. pseudomallei in vivo fitness.
Proceedings Of The Mammal Research Institute 50Th Anniversary Symposium. Mammal Research In Southern Africa: A Blueprint For The Next Two Decades.
Creators: name: Mammal Research Institute
Publisher: name: Zenodo
Year: 2016
Subjects: Mammal
Research
Africa

description: Proceedings of the Mammal Research Institute 50th anniversary Symposium. Mammal research in southern Africa: a blueprint for the next two decades.
Rough Volatility: pushing the boundaries of quantitative modelling past the Markovian era
Creators: name: Muguruza Gonzalez, Aitor
Publisher: name: Imperial College London
Year: 2022

description: Rough volatility models have brought a breeze of fresh air into financial modelling, which historically has been mostly tied to Markovian models. Alas, this novelty comes with a number of challenges and questions that require new techniques to be answered. The present thesis first explores the numerical implementation of rough volatility models, both to provide convergence results and to ensure a competitive implementation. Our findings conclude that fractional calculus and Hölder spaces provide the right framework to set the theoretical grounds of numerical schemes related to rough volatility models and fractional diffusions in general. In addition, we explore the use of deep learning methods to leverage the speed of numerical schemes and provide state-of-the-art calibration techniques that make rough volatility models as simple and efficient to implement as the Black-Scholes formula. The second part of the thesis explores the theoretical properties of rough volatility models regarding volatility products such as VIX and realized variance options. We explore short-time asymptotics using two different techniques: Malliavin Calculus and Large Deviations Principle. Remarkably, we find that both approaches complement each other and provide a very accurate description of the short-time implied volatility smile. Building upon these short-time asymptotics, we further provide approximation formulas for the at-the-money implied volatility and its skew. Finally, in the third part of the thesis we cross the bridge between the physical P and risk-neutral Q measures. We provide sufficient conditions for such change of measure to be well defined and explore the numerical estimation of the market risk premium process in rough volatility models.
Rewording the world: narrative and nature after poststructuralism
Creators: name: Gough, Noel
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2015 Sense Publishers. All rights reserved. In this essay I address the question, ˜What am I to do?" as an outdoor and environmental educator with some responsibilities for facilitating learnersâ€™ experiences of the outdoors, by exploring some of the stories in which my colleagues and I find ourselves a part.
Advancing pressure injury prevention around the globe: from the Pan Pacific region to an international pressure injury guideline
Creators: name: Haesler, Emily
name: Carville, K
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3202
subject: Clinical sciences

description: https://journals.cambridgemedia.com.au/application/files/3616/0498/7140/2302_03.pdf Informit DOI: https://search.informit.org/doi/10.3316/informit.308994692790462
Supplementary document for Untrained deep learning-based differential phase-contrast microscopy - 6441072.pdf
Creators: name: Seong, Baekcheon
name: KIM, INGYOUNG
name: Moon, Taegyun
name: Malith, Ranathunga
name: Kim, Daesuk
name: Joo, Chulmin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement1 for supporting content.
The foot-health of adult diabetics in regional Australia: baseline findings from an epidemiological study
Creators: name: Perrin, Byron
name: Allen, Penny
name: Skinner, Isabelle
name: Gardner, Marcus
name: Chappell, Andrew
name: Phillips, Bronwyn
name: Massey, Claire
name: Skinner, Timothy
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4206
subject: Public health
classificationCode: 4207
subject: Sports science and exercise

description: No description supplied