cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pimozide and adipic acid: a new multicomponent crystalline entity for improved pharmaceutical behavior
Creators: name: Buscarini, Alessandra
name: Zaworotko, Michael
name: Matos, Catiúcia R. M. O.
name: Grepioni, Fabrizia
name: Contini, Laura
name: Capsoni, Doretta
name: Friuli, Valeria
name: Maggi, Lauretta
name: Bruni, Giovanna
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Pimozide is a first-generation antipsychotic used in the treatment of schizophrenia, Gilles de la Tourette syndrome, and other chronic psychoses. Its in vivo efficacy is limited by poor solubility and consequent poor bioavailability. Therefore, adipic acid was used as a coformer for the preparation of a binary product with improved pharmaceutical properties. The thermal behavior of the liquid-assisted grinding products of compositions included in the range 0.1 < XPMZ < 0.9 has been interpreted using a thermo-dynamic model according to which the two components originate a new crystalline entity in molar ratio pimozide:adipic acid 0.66:0.33, which forms an eutectic system with adipic acid. The model was confirmed using the quantitative analysis of the melting peaks and using the X-ray diffraction measurements from powders and single crystals. In particular, the latter have demonstrated that the new entity resulting from the pimozide:adipic acid 0.66:0.33 composition is actually salt [PMZH]2 [adipate]. The crystalline product was characterized, from a pharmaceutical perspective, in terms of solubility and wettability (contact angle). Then, a tablet formulation was developed, and its dissolution behavior was compared to a commercial product considered as a reference. The new entity showed improved pharmaceutical properties in terms of solubility and wettability compared to the pure drug in both deionized water and bio-relevant fluids simulating oral administration in fed and fasted conditions. The tablets containing the new crystalline form can make this virtually insoluble drug available for absorption within minutes regardless of the variability in gastric conditions
Evolution and organization of the human protein C gene.
Creators: name: Plutzky, J.
name: Long, G. L.
name: Crabtree, G. R.
name: Hoskins, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: We have isolated overlapping phage genomic clones covering an area of 21 kilobases that encodes the human protein C gene. The gene is at least 11.2 kilobases long and is made up of nine exons and eight introns. Two regions homologous to epidermal growth factor and transforming growth factor are encoded by amino acids 46-91 and 92-136 and are precisely delimited by introns, as is a similar sequence in the genes for coagulation factor IX and tissue plasminogen activator. When homologous amino acids of factor IX and protein C are aligned, the positions of all eight introns correspond precisely, suggesting that these genes are the product of a relatively recent gene duplication. Nevertheless, the two genes are sufficiently distantly related that no nucleic acid homology remains in the intronic regions and that the size of the introns varies dramatically between the two genes. The similarity of the genes for factor IX and protein C suggests that they may be the most closely related members of the serine protease gene family involved in coagulation and fibrinolysis.
Interactive Video and Multiple Choice Question ‘Flipped Classrooms’
Creators: name: Timmins, V. M. S.
Publisher: name: The School of Education and Communities, University of East London
Year: 2018

description: As part of the Postgraduate Certificate course in Teaching and Learning in Higher Education (PGCert), I wrote a plan involving the creation of ‘flipped classroom’ sessions that may form part of the BSc Psychology first-year (Level 4) research methods module at the University of East London (UEL). Psychology students generally do not find this statistics-heavy module very easy, seemingly due to a lack of understanding of the underlying, more basic concepts. The proposed sessions would encompass short ‘micro-teach’ videos on those basic concepts, interspersed with multiple choice questions (MCQs) to test learning. These would then be followed by in-class discussions on the areas of weakness highlighted by the MCQ answers. A pilot session is proposed with one set of four or five mini-topics, covered in a ‘flipped classroom’ video/MCQ format. (At the point of submitting this paper, the pilot session has not yet been put in place.)
Caught in the act: Measuring the changes in the corona that cause the extreme variability of 1H 0707-495
Creators: name: Wilkins, D. R.
name: Kara, E.
name: Fabian, A. C.
name: Gallo, L. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The X-ray spectra of the narrow line Seyfert 1 galaxy, 1H 0707-495, obtained with XMM-Newton, from time periods of varying X-ray luminosity are analysed in the context of understanding the changes to the X-ray emitting corona that lead to the extreme variability seen in the X-ray emission from active galactic nuclei (AGN). The emissivity profile of the accretion disc, illuminated by the X-ray emitting corona, along with previous measurements of reverberation time lags are used to infer the spatial extent of the X-ray source. By fitting a twice-broken power law emissivity profile to the relativistically-broadened iron K fluorescence line, it is inferred that the X-ray emitting corona expands radially, over the plane of the accretion disc, by 25 to 30 per cent as the luminosity increases, contracting again as the luminosity decreases, while increases in the measured reverberation lag as the luminosity increases would require also variation in the vertical extent of the source above the disc. The spectrum of the X-ray continuum is found to soften as the total X-ray luminosity increases and we explore the variation in reflected flux as a function of directly-observed continuum flux. These three observations combined with simple, first-principles models constructed from ray tracing simulations of extended coron self-consistently portray an expanding corona whose average energy density decreases, but with a greater number of scattering particles as the luminosity of this extreme object increases.
description: 12 pages, 4 figures. Accepted for publication in MNRAS
Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors.
Creators: name: Ball, L. A.
name: Collins, P. L.
name: Young, K. K.
name: Anderson, K.
name: Wertz, G. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The major glycoprotein, G, of human respiratory syncytial (RS) virus is a M
Challenges in the Use of Alternative Fuels: Solutions to handle Boil-Off Gas in Agricultural Machines
Creators: name: Pult, Felix
name: Stein, Alexander
name: Geimer, Marcus
Publisher: name: VDI Verlag
Year: 2022

description: To meet the climate targets, it is necessary to reduce greenhouse gas emissions from all areas. Liquefied Natural Gas (LNG), which consists largely of methane, can be produced sustainably and it is suitable for mobile machines due to its high energy density. When storing LNG at ambient temperatures, evaporation creates boil-off gas. Methane is a climate-damaging greenhouse gas that must not be released into the environment. Therefore, in this paper, concepts are developed and evaluated that enable the use of LNG in mobile machines without blowing off gas during dormant periods. Using a simulation model, the components of the most suitable concept for a combine harvester are selected and dimensioned.
Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen.
Creators: name: Bishop, G. A.
name: Haughton, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The present study used cocultures of clonally derived B and T cells, together with an antigen reactive with the membrane Ig of the clonal B cells, to address the issue of B-cell differentiation requirements. The B cells were CH12.LX, an in vitro grown subclone of a murine B-cell lymphoma, which bears surface IgM reactive with sheep erythrocytes. The T cells were alloreactive T-helper-cell hybridomas. Very small numbers of T-helper cells could induce differentiation of cloned B cells without the presence of accessory cells, but such induction was dependent upon the presence of the antigen recognized by the B cell. Induced differentiation of the B cells did not depend on metabolic activity of the T cells, and metabolically active T cells could be replaced by fixed cells or by monoclonal antibody reactive with the class II molecule of the B cell to deliver an Ia-specific differentiative signal. T cells, or alloantibody that reacted with the I-E molecule, induced differentiation of the B cells; those that reacted with the I-A molecule did not. These results define the minimal requirements for major histocompatibility complex-restricted, T-cell-mediated induction of B-cell differentiation.
Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.
Creators: name: Kole, R.
name: Furdon, P. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Human beta-globin mRNAs truncated in the second exon or in the first intron have been processed in vitro in a HeLa cell nuclear extract. Transcripts containing a fragment of the second exon as short as 53 nucleotides are efficiently spliced, whereas transcripts truncated 24 or 14 nucleotides downstream from the 3' splice site are spliced inefficiently, if at all. All of these transcripts, however, are efficiently and accurately cleaved at the 5' splice site. In contrast, RNA truncated in the first intron, 54 nucleotides upstream from the 3' splice site, is not processed at all. These findings suggest that cleavage at the 5' splice site and subsequent splicing steps--i.e., cleavage at the 3' splice site and exon ligation--need not be coupled. Anti-Sm serum inhibits the complete splicing reaction and cleavage at the 5' splice site, suggesting involvement of certain ribonucleoprotein particles in the cleavage reaction. ATP and Mg2+ are required for cleavage at the 5' splice site at concentrations similar to those for the complete splicing reaction.
q-Frequently hypercyclic operators
Creators: name: Gupta, Manjul
name: Mundayadan, Aneesh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A16

description: We introduce q-frequently hypercyclic operators and derive a sufficient criterion for a continuous operator to be q-frequently hypercyclic on a locally convex space. Applications are given to obtain q-frequently hypercyclic operators with respect to the norm-, F-norm- and weak*- topologies. Finally, the frequent hypercyclicity of the non-convolution operator $T_μ$ defined by $T_μ(f)(z) = f'(μz)$, $μ\ge1$ on the space $H(\mathbb{C})$ of entire functions equipped with the compact-open topology is shown.
description: 13 pages, to appear
Conceptualizing fairness in the secondary use of health data for research: a scoping review
Creators: name: Cervera de la Cruz, Patricia
name: Shabani, Mahsa
Publisher: name: Zenodo
Year: 2023

description: With the introduction of the European Health Data Space (EHDS), the secondary use of health data for research purposes is set to rapidly escalate. Secondary health data processing promises to address novel research questions, inform the design of future research and improve healthcare delivery generally. To comply with the existing data protection regulations, the secondary data use must be fair to individuals, among other things. However, there is no clear understanding of what fairness means in the context of secondary use of health data for scientific research purposes. In response, we conducted a scoping review of argument-based literature to explore how fairness for the individuals in the secondary use of health data has been conceptualized. Our review has revealed that balancing individual and public interests, reducing power asymmetries, setting conditions for commercial involvement and implementing benefit sharing were essential to guarantee fair secondary use research for individuals. The findings of this review can inform current and future research practices and policy development in order to adequately address concerns about fairness in the secondary use of health data.
Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.
Creators: name: Errede, B.
name: Teague, M. A.
name: Chaleff, D. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The nucleotide sequence of the STE7 gene from Saccharomyces cerevisiae has been determined. It is one of several regulatory genes implicated in the control of cell-type-specific gene expression in yeast. The predicted amino acid sequence shows homology to several members of the protein kinase family. These results suggest protein phosphorylation may play a key role in regulation leading to cell-type specialization in yeast.
Nucleotide sequences for the gene junctions of human respiratory syncytial virus reveal distinctive features of intergenic structure and gene order.
Creators: name: Dickens, L. E.
name: Camargo, E.
name: Olmsted, R. A.
name: Buckler-White, A.
name: Collins, P. L.
name: Spriggs, M. K.
name: Coelingh, K. V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Complete sequences for the intergenic regions of the genome of human respiratory syncytial virus were obtained by dideoxynucleotide sequencing using synthetic oligonucleotides. These experiments established that the 10 respiratory syncytial viral genes are arranged, without additional intervening genes, in the order 3' 1C-1B-N-P-M-1A-G-F-22K-L 5'. For the first nine genes, the exact gene boundaries were identified by comparison of the genomic sequences with previously determined mRNA sequences. The intergenic regions varied in length from 1 to 52 nucleotides and lacked any obvious conserved features of primary or secondary structure except that each sequence ended (3' to 5') with an adenosine residue. The exact start site of the 10th gene, the L gene, was not determined. However, RNA blot hybridization using a synthetic oligonucleotide designed from the genomic sequence mapped the L gene to within 54 nucleotides of the end of the penultimate 22K gene. The lack of conservation of chain length and nucleotide sequence for the respiratory syncytial viral intergenic regions, together with the complexity of the genetic map, contrasts with previous observations for other nonsegmented negative-strand viruses.
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.
Creators: name: Pledger, W. J.
name: O'Keefe, E. J.
name: Olashaw, N. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Platelet-derived growth factor (PDGF) and phorbol 12-myristate 13-acetate (PMA) decrease high affinity binding of 125I-labeled epidermal growth factor (EGF) and potentiate mitogenesis in BALB/c 3T3 cells, and both have been shown to induce the phosphorylation of the EGF receptor at threonine residues. These similarities suggest that the actions of PDGF on EGF binding may be mediated by protein kinase C, the cellular effector of PMA. We show that in density-arrested BALB/c 3T3 cells PDGF and PMA induce a rapid, transient, cycloheximide-independent loss of EGF binding activity. As has been previously shown for PDGF, the ability of PMA to reduce EGF binding was enhanced by cholera toxin, a potent activator of adenylate cyclase. In contrast to PMA, however, PDGF induced a further reduction in EGF binding that was strictly dependent upon continued protein synthesis. Furthermore, PDGF effectively reduced EGF binding in cells refractory to PMA. Cells desensitized to PMA, presumably due to the loss of protein kinase C activity, also remained mitogenically responsive to PDGF. These data suggest that the mechanism by which PDGF modulates EGF binding differs from that of PMA and thus, at least in part, is independent of protein kinase C.
Steady-state ab initio laser theory for complex gain media
Creators: name: Cerjan, Alexander
name: Chong, Y. D.
name: Stone, A. Douglas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We derive and test a generalization of Steady-State Ab Initio Laser Theory (SALT) to treat complex gain media. The generalized theory (C-SALT) is able to treat atomic and molecular gain media with diffusion and multiple lasing transitions, and semiconductor gain media in the free carrier approximation including fully the effect of Pauli blocking. The key assumption of the theory is stationarity of the level populations, which leads to coupled self-consistent equations for the populations and the lasing modes that fully include the effects of openness and non-linear spatial hole-burning. These equations can be solved efficiently for the steady-state lasing properties by a similar iteration procedure as in SALT, where a static gain medium with a single transition is assumed. The theory is tested by comparison to much less efficient Finite Difference Time Domain (FDTD) methods and excellent agreement is found. Using C-SALT to analyze the effects of varying gain diffusion constant we demonstrate a cross-over between the regime of strong spatial hole burning with multimode lasing to a regime of negligible spatial hole burning, leading to gain-clamping, and single mode lasing. The effect of spatially inhomogeneous pumping combined with diffusion is also studied and a relevant length scale for spatial inhomogeneity to persist under these conditions is determined. For the semiconductor gain model, we demonstrate the frequency shift due to Pauli blocking as the pumping strength changes.
description: 15 pages, 5 figures
Platelets contain a peptide inhibitor of endothelial cell replication and growth.
Creators: name: Clemmons, D. R.
name: Brown, M. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Platelets release specific growth factors that stimulate division of aortic endothelial cells. Acidification or heating to 56 degrees C of platelet extracts is required to detect these factors. Nonheated platelet extracts inhibit endothelial growth. To determine if this inhibitory effect is due to a discrete chemical substance, a crude extract obtained by freezing and thawing human platelets was incubated with an endothelial cell mitogen and found to inhibit the endothelial cell incorporation of [
7 Briefe an Gebrüder [Johann Leonhart] Hartmann, Hartmann
Brief an Hartmann ...
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1772

description: von Johann Caspar Lavater
description: Davon 2 Briefe nur an Johann Leonhart Hartmann
description: Davon 1 Brief mit Beischrift von Anna Lavater-Schinz an die Gebr. Hartmann in St. Gallen, dat. 14.10.1775
description: Gebrüder Hartmann: in St. Gallen
Tips & Tricks informatiques
Creators: name: Maire, Mariana
Publisher: name: Zenodo
Year: 2022
Subjects: formation
informatique
windows

description: Support de formation présentant des trucs et astuces informatiques basiques sous Windows : raccourcis clavier, paramètres d’affichage, outils pratiques (linguistiques, graphiques), outils de collaboration (partage de documents, organisation).
RecA protein filaments can juxtapose DNA ends: an activity that may reflect a function in DNA repair.
Creators: name: Griffith, J.
name: Register, J. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: To further characterize the role of RecA protein-DNA filaments in general recombination and DNA repair, we have examined interactions of these filaments with themselves following formation. When linear double-stranded DNA was incubated with RecA in the presence of Mg2+ and adenosine 5'-[gamma-thio]triphosphate, monomer-length (1n) nucleoprotein filaments were observed. Following continued incubation, filaments having 2n, 3n, ... lengths were observed, indicating that an end-to-end joining of the monomer-length filaments had occurred. When linear single-stranded DNA was covered by RecA protein under several conditions, the ends of the resulting filaments joined together rapidly, producing circular filaments. The end-to-end joining of single-stranded DNA-RecA filaments appeared to require that 3' DNA ends be juxtaposed with 5' DNA ends, because double-stranded DNA molecules having long single-stranded DNA tails with only 3' or 5' termini did not join end-to-end. However, when both 5' and 3' ends were present in the reaction, joining was observed. We suggest that this end-to-end joining activity may help explain the role of RecA protein in both the protection of damaged DNA ends and the repair of double-stranded DNA breaks.
title: Community care experiments for frail older people : two care management programmes evaluated
Creators: name: Chesterman, John Francis
Publisher: name: University of Kent
Year: 2003

description: The inadequacy of community-based services for frail older people in the 1970s pointed to the need for providing co-ordinated care responsive to multiple needs. The fully evaluated Kent Community Care Project (KCCP), a care management experiment which pioneered this new approach, successfully maintained users for longer at home with enhanced quality of life at no additional cost. While the KCCP benefited from intensive support from the evaluation team, there was a need to investigate whether schemes set up in other areas could be successful when the promotion of good practice was limited to that provided by the agency. The schemes evaluated in this study were early replications of the KCCP in two contrasting parts of Kent. County-wide mechanisms were set up to encourage good practice, such as regular meetings of field staff and managers on policy and practice issues, a working group to develop procedures, peer review and monitoring and feedback. A full cost-effectiveness analysis was undertaken on each of the two schemes using a quasi-experimental design with before/after evaluation interviews on matched experimental and control groups over a one year period which was costed. Both schemes successfully maintained users at home for significantly longer, and achieved significant improvements in quality of life, quality of care and health status, though less striking than in the KCCP, again at no additional cost. However, they differed from the KCCP in causing a considerable shift in expenditure from health services to social services, with a consequent striking reduction in hospital bed-blocking as well as care home use. Cost-outcomes analyses suggested that budget caps were too generous for resources to be deployed most efficiently. Because this study took place during the early 1980s, it has been treated largely in its historical context. Nevertheless, the investigation also suggests some important ways in which the current practice of post-reform care management might be improved.
Measuring the orbital periods of low mass X-ray binaries in the X-ray band
Creators: name: Chou, Yi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A low mass X-ray binary (LMXB) contains either a neutron star or a black hole accreting materials from its low mass companion star. It is one of the primary astrophysical sources for studying the stellar size compact objects and the accreting phenomena. As with other binary systems, the most important parameter of an LMXB is the orbital period, which allows us to learn about the nature of the binary system and constrain the properties of the system's components, including the compact object. As a result, measuring the orbital periods of LMXBs is essential for investigating these systems even though fewer than half of them have known orbital periods. This article introduces the different methods for measuring the orbital periods in the X-ray band and reviews their application to various types of LMXBs, such as eclipsing and dipping sources, as well as pulsar LMXBs.
description: 19 pages, 8 figures, invited review to appear in RAA
On Cohomology for Product Systems
Creators: name: Hong, Jeong Hee
name: Son, Mi Jung
name: Szymanski, Wojciech
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L08, 46L65, 18G10

description: A cohomology for product systems of Hilbert bimodules is defined via the Ext functor. For the class of product systems corresponding to irreversible algebraic dynamics, relevant resolutions are found explicitly and it is shown how the underlying product system can be twisted by the 2-cocycles. In particular, this process gives rise to cohomological deformations of the C*-algebras associated with the product system. Concrete examples of deformations of the Cuntz's algebra Q_N arising this way are investigated and we show they are simple and purely infinite.
description: 15 pages
[2 Ansichten von Basel]
Creators: name: Höflinger, Jakob
Publisher: name: [s.n.]
Year: 1875
Subjects: Vedute

description: Basler Stadtansichten
description: [Augustinergasse in Richtung Münster]
description: [Statue des Joahnnes Oekolampad vor dem Kreuzgang des Basler Münster]
description: J. Höflinger
description: Es handelt sich bei den Fotografien um Albuminabzüge
Using AI Technologies - a resource for lecturers to use with their students
Creators: name: Seery, Michael
K.
Publisher: name: National Teaching Repository
Year: 2023
Subjects: Higher education

description: This resource shares some materials for lecturers to incorporate into their teaching regarding the support of meaningful use of AI tools. It intends to show some positive aspects of the role of AI, and includes a variety of practice-based exemplars, discussion prompts, and considerations to share with students.
Lehrplan für eine Klasse für textile Flächenkunst an der Itten-Schule Berlin
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1932

description: Beilagen: Fotokopie des Lehrplans; Mitteilung an die Schüler der Itten-Schule Berlin; Notiz von Anneliese Itten
Structure and expression of a tandem duplication of the Drosophila metallothionein gene.
Creators: name: Otto, E.
name: Young, J. E.
name: Maroni, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: A strain of cadmium-resistant Drosophila containing a chromosomal duplication of the metallothionein gene was isolated. This duplication is stably inherited in the absence of selective pressure, and larvae homozygous for it can produce approximately twice as much metallothionein RNA as wild-type larvae. The entire duplication was cloned within a 5.7-kilobase fragment; this fragment contained a direct, tandem repeat of 2.2 kilobases of DNA: 228 bases of 5' flanking DNA, the entire transcription unit, and 1.4 kilobases of 3' flanking sequences. The 3' region of the first repeated unit is joined to the 5' region of the second unit by a 6-base-pair segment we define as the novel joint. This joint forms part of a 10-base-pair inverted repeat of a segment within the 3' region of the first unit. Comparison of the sequences of the 5' and 3' boundaries revealed no extensive regions of similarity at a position corresponding to the novel joint, thus suggesting that a mechanism other than homologous recombination was involved in the origin of this duplication.
Fingering versus stability in the limit of zero interfacial tension
Creators: name: Bischofberger, Irmgard
name: Ramachandran, Radha
name: Nagel, Sidney R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The invasion of one fluid into another of higher viscosity in a quasi-two dimensional geometry typically produces complex fingering patterns. Because interfacial tension suppresses short-wavelength fluctuations, its elimination by using pairs of miscible fluids would suggest an instability producing highly ramified singular structures. Previous studies focused on wavelength selection at the instability onset and overlooked the striking features appearing more globally. Here we investigate the non-linear growth that occurs after the instability has been fully established. We find a rich variety of patterns that are characterized by the viscosity ratio between the inner and the outer fluid, $η_{in}$/$η_{out}$, as distinct from the most-unstable wavelength, which determines the onset of the instability. As $η_{in}$/$η_{out}$ increases, a regime dominated by long highly-branched fractal fingers gives way to one dominated by blunt stable structures characteristic of proportionate growth. Simultaneously, a central region of complete outer-fluid displacement grows until it encompasses the entire pattern at $η_{in}$/$η_{out}$$\approx$0.3.
Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension
Creators: name: Logantha, Sunil Jit R. J.
name: Yamanushi, Tomoko T.
name: Absi, Mais
name: Temple, Ian P.
name: Kabuto, Hideaki
name: Hirakawa, Eiichiro
name: Quigley, Gillian
name: Zhang, X.
name: Gurney, Alison M.
name: Hart, George
name: Zhang, Henggui
name: Dobrzynski, Halina
name: Boyett, Mark R.
name: Yanni, Joseph
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Physiology
subject: FOS: Biological sciences

description: Electronic supplementary material: methods, results, references, table and figure
Too many shoes? An exploratory study of footwear and sustainability
Creators: name: Braithwaite, Naomi J.
name: Marroncelli, Rose
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 500 Naturwissenschaften und Mathematik
subject: 600 Technik, Technologie
subject: 300 Sozialwissenschaften
subject: footwear
subject: consumer attitudes
subject: sustainability
subject: trainers
subject: high heels

description: As the debates surrounding fashion and its impact on the environment gain momentum, there is an urgent need to address footwear’s impact on sustainability. Over the last decade a fast fashion industry has developed in the UK which could result in a shorter life expectancy of shoes. As sales increase so has the volume of footwear going to landfill. Despite all of this, shoes are notably absent from the research and discussions on the environmental implications of fashion. This exploratory paper draws from findings of a research project that investigates the UK shoe industry over the last 20 years, with a particular focus on understanding consumer relationships with shoes from purchase, use and disposal, and how that raises questions for the development of a more sustainable footwear industry. The paper will use findings from a literature review and the creation of a footwear dataset which stems from object analysis of a contemporary shoe archive, to investigate the relationship between the footwear industry and sustainability. Reflecting on data from interviews, wardrobe studies and focus groups with consumers, the paper will present perspectives on the under explored field of shoes and sustainability, addressing gaps in knowledge and fleshing out areas for future research.
Line arrangements with the maximal number of triple points
Creators: name: Dumnicki, Marcin
name: Farnik, Lucja
name: Glowka, Agata
name: Lampa-Baczynska, Magdalena
name: Malara, Grzegorz
name: Szemberg, Tomasz
name: Szpond, Justyna
name: Tutaj-Gasinska, Halszka
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 52C30, 05B30, 14Q10

description: The purpose of this note is to study configurations of lines in projective planes over arbitrary fields having the maximal number of intersection points where three lines meet. We give precise conditions on ground fields F over which such extremal configurations exist. We show that there does not exist a field admitting a configuration of 11 lines with 17 triple points, even though such a configuration is allowed combinatorially. Finally, we present an infinite series of configurations which have a high number of triple intersection points.
description: 16 pages, 10 figures
SPIRITS: Software for the Processing and Interpretation of Remotely Sensed Image Time Series
Creators: name: Vito
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Satellite Image Time Series
Interpretation
Processing
Sensed image

description: SPIRITS (Software for the Processing and Interpretation of Remotely Sensed Image Time Series) was developed by VITO for the Food Security unit of the Joint Research Centre. It is a software environment for analyzing satellite derived image time series for crop and vegetation monitoring in an integrated and flexible analysis environment and with a user-friendly graphical interface. With this toolbox, you can process and examine time series of low and medium resolution sensors. It can be used to perform and to automate many spatial and temporal processing steps on time series and to extract spatially aggregated statistics. Vegetation indices and their anomalies can be rapidly mapped and statistics can be plotted in seasonal graphs to be shared with analysts and decision makers.  
This presentation introduces the main features available in SPIRITS.
Financial schemes for energy efficiency projects: lessons learnt from in-country demonstrations
Creators: name: Karakosta, Charikleia
name: Papapostolou, Aikaterini
name: Vasileiou, George
name: Psarras, John
Publisher: name: Zenodo
Year: 2020
Subjects: Energy Efficiency
Funding Schemes
Risk Mitigation
Stakeholder Dialogue
Best Practices
Lessons Learnt
Capacity Building
Knowledge Transfer
In-Country Demonstrations

description: Description: This is the final accepted manuscript of the book chapter "Financial schemes for energy efficiency projects: lessons learnt from in-country demonstrations", of book "Energy Services Fundamentals and Financing 1st Edition". Abstract: Traditional investment institutions face a lack of understanding regarding the technical aspects of energy efficiency investments. Indeed, due to the heterogeneity of such investments and to the immaturity of the market the entry into this business is unattractive for many financial institutions, although energy efficiency projects can often present a guaranteed return. The aim of this paper is to propose a methodological framework on energy efficiency investments and robust financing programs/models in targeted case study countries that will act as first-of-a-kind demonstration for the banks, institutional investors and asset managers, with the use of approaches based on knowledge transfer and capacity building among key actors. The experience gathered from in-country demonstration will also facilitate and accelerate the replicability, while findings could then be used to lead to concrete recommendations towards a successfully energy efficiency financing.
Vortrag "Schöpferischer Automatismus"
Creators: name: Itten, Johannes
Publisher: name: [s.n.]
Year: 1958

description: Enthält: 2 Entwurfsmanuskripte von der Hand Johannes Ittens; 1 Typoskript (3 Exemplare); 1 Typoskript zu Lichtbildervortrag; 1 Typoskript (wohl fragmentarisch) / Johannes Itten hielt diesen Vortrag im August 1958 beim Kongress der Internationalen Vereinigung für Kunsterziehung in Basel.
Vortrag "Subjektive und objektive Gestaltung"
Creators: name: Itten, Johannes
Publisher: name: [s.n.]
Year: 1964

description: Enthält: 1) Manuskript "Vortrag: Subjektive und objektive Gestaltung" (9 Blätter), letztes Blatt mit Notizen Johannes Ittens; 2) Typoskript "Vortrag: Subjektive und objektive Gestaltung" (4 Blätter), 3 Exemplare, 2 davon mit eingezeichneten Korrekturen, 1 Exemplar mit Notizen von Anneliese Itten
The Anonymus Harvardianus, Alessandro Bondino (alias Ἀλέξανδρος Ἀγαθήμερος), and the Role of the Manuscript Napoli III D 37 in Some Editiones Principes of Aristotelian Works
Creators: name: Maksimczuk, José
Publisher: name: Parekbolai. An Electronic Journal for Byzantine Literature
Year: 2023
Subjects: Aristotle; Organon; Aldus Manutius

description: This paper probes the history of the Organon manuscript Napoli III D 37 (ca. 1360-1375). The author offers palaeographical, historical, and text-critical evidence that the Neapolitanus passed through the hands of the so-called Anonymus Harvardianus and Alessandro Bondino by the late 15th and early 16th century. In the second part of the article, the author provides arguments that Napoli III D 37 was one of the manuscripts used by Aldus Manutius and his coadjutors to produce the text of the editio princeps of Aristotle's Analytica priora in 1495.
description: Parekbolai. An Electronic Journal for Byzantine Literature, Vol 13 (2023)
WASP-104b and WASP-106b: two transiting hot Jupiters in 1.75-day and 9.3-day orbits
Creators: name: Smith, A. M. S.
name: Anderson, D. R.
name: Armstrong, D. J.
name: Barros, S. C. C.
name: Bonomo, A. S.
name: Bouchy, F.
name: Brown, D. J. A.
name: Cameron, A. Collier
name: Delrez, L.
name: Faedi, F.
name: Gillon, M.
name: Chew, Y. Gómez Maqueo
name: Hébrard, G.
name: Jehin, E.
name: Lendl, M.
name: Louden, T. M.
name: Maxted, P. F. L.
name: Montagnier, G.
name: Neveu-VanMalle, M.
name: Osborn, H. P.
name: Pepe, F.
name: Pollacco, D.
name: Queloz, D.
name: Rostron, J. W.
name: Segransan, D.
name: Smalley, B.
name: Triaud, A. H. M. J.
name: Turner, O. D.
name: Udry, S.
name: Walker, S. R.
name: West, R. G.
name: Wheatley, P. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the discovery from the WASP survey of two exoplanetary systems, each consisting of a Jupiter-sized planet transiting an 11th magnitude (V) main-sequence star. WASP-104b orbits its star in 1.75 d, whereas WASP-106b has the fourth-longest orbital period of any planet discovered by means of transits observed from the ground, orbiting every 9.29 d. Each planet is more massive than Jupiter (WASP-104b has a mass of $1.27 \pm 0.05 \mathrm{M_{Jup}}$, while WASP-106b has a mass of $1.93 \pm 0.08 \mathrm{M_{Jup}}$). Both planets are just slightly larger than Jupiter, with radii of $1.14 \pm 0.04$ and $1.09 \pm 0.04 \mathrm{R_{Jup}}$ for WASP-104 and WASP-106 respectively. No significant orbital eccentricity is detected in either system, and while this is not surprising in the case of the short-period WASP-104b, it is interesting in the case of WASP-106b, because many otherwise similar planets are known to have eccentric orbits.
description: 8 pages, 6 figures, 5 tables. Accepted for publication in A&A
Range-separated meta-GGA functional designed for noncovalent interactions
Creators: name: Modrzejewski, Marcin
name: Chałasiński, Grzegorz
name: Szczęśniak, Małgorzata M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The accuracy of applying density functional theory to noncovalent interactions is hindered by errors arising from low-density regions of interaction-induced change in the density gradient, error compensation between correlation and exchange functionals, and dispersion double counting. A new exchange-correlation functional designed for noncovalent interactions is proposed to address these problems. The functional consists of the range-separated PBEsol exchange considered in two variants, pure and hybrid, and the semilocal correlation functional of Modrzejewski et al. [J. Chem. Phys. 137, 204121 (2012)] designed with the constraint satisfaction technique to smoothly connect with a dispersion term. Two variants of dispersion correction are appended to the correlation functional: the atom-atom pairwise additive DFT-D3 model and the density-dependent many-body dispersion with self-consistent screening (MBD-rsSCS). From these building blocks a set of four functionals is created to systematically examine the role of pure versus hybrid exchange and the underlying models for dispersion. The new functional is extensively tested on benchmark sets with diverse nature and size. The truly outstanding performance is demonstrated for water clusters of varying size, ionic hydrogen bonds, and thermochemistry of isodesmic n-alkane fragmentation reactions. The merits of each component of the new functional are discussed.
DYNAMIC INTERPLAY BETWEEN SPECTRIN, ACTIN AND PLASMA MEMBRANE DURING CELL MECHANORESPONSE
Creators: name: GALLI, CAMILLA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: The spectrin cytoskeleton is a major component of the mammalian cell cortex. While long known and ubiquitously expressed, its dynamic behaviour and cooperation with other major components of the cell cortex is poorly understood. Here we investigated spectrin reactions upon different mechanical cues, such as cell-driven perturbations, like cell adhesion, spreading and contraction, or environmentally driven ones, like compression, stretch and osmotic changes. Upon all of these challenges we observed that spectrin meshwork spatially adapts and reorganizes under the plasma membrane together with the acto-myosin cytoskeleton. Working together to maintain cell integrity, both cytoskeletons define specific membrane territories. Actin-rich regions control protrusions, adhesions and stress fibers, whereas spectrin-rich regions concentrate in retractile zones, covering low actin density territories of the cortex. Given this interplay, we wondered if spectrin could be potentially involved in the spatial and temporal regulation of membrane trafficking. We followed spectrin, actin and clathrin dynamics through live TIRF microscopy and observed an inverted correlation between spectrin and actin densities and endocytic capacities, suggesting a spectrin contribution to clathrin-mediated endocytosis. Our results pinpoint a role for spectrin in the support of the lipid bilayer in regions where actin cytoskeleton is not established, creating a fencing mechanism for actin remodelling and cargoes internalization. All these mechanisms potentially unveil why the spectrin family of protein is evolutionary highly conserved and ubiquitously expressed in eukaryotic cells, and might explain its involvement in a broad range of pathological condition.
Magnetic structure of GdBiPt: A candidate antiferromagnetic topological insulator
Creators: name: Müller, R. A.
name: Lee-Hone, N. R.
name: Lapointe, L.
name: Ryan, D. H.
name: Pereg-Barnea, T.
name: Bianchi, A. D.
name: Mozharivskyj, Y.
name: Flacau, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A topological insulator is a state of matter which does not break any symmetry and is characterized by topological invariants, the integer expectation values of non-local operators. Antiferromagnetism on the other hand is a broken symmetry state in which the translation symmetry is reduced and time reversal symmetry is broken. Can these two phenomena coexist in the same material? A proposal by Mong {\it et al.}\cite{Mong2010} asserts that the answer is yes. Moreover, it is theoretically possible that the onset of antiferromagnetism enables the non-trivial topology since it may create spin-orbit coupling effects which are absent in the non-magnetic phase. The current work examines a real system, half-Heusler GdBiPt, as a candidate for topological anti ferromagnetism. We find that the magnetic moments of the gadolinium atoms form ferromagnetic sheets which are stacked antiferromagnetically along the body diagonal. This magnetic structure may induce spin orbit coupling on band electrons as they hop perpendicular to the ferromagnetic sheets.
description: 6 pages, 4 figures. Accepted for publication in Phys. Rev. B Rapid Comm
Approaching the Asymptotic Regime of Rapidly Rotating Convection: Boundary Layers vs Interior Dynamics
Creators: name: Stellmach, S.
name: Lischper, M.
name: Julien, K.
name: Vasil, G.
name: Cheng, J. S.
name: Ribeiro, A.
name: King, E. M.
name: Aurnou, J. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Rapidly rotating Rayleigh-Bénard convection is studied by combining results from direct numerical simulations (DNS), laboratory experiments and asymptotic modeling. The asymptotic theory is shown to provide a good description of the bulk dynamics at low, but finite Rossby number. However, large deviations from the asymptotically predicted heat transfer scaling are found, with laboratory experiments and DNS consistently yielding much larger Nusselt numbers than expected. These deviations are traced down to dynamically active Ekman boundary layers, which are shown to play an integral part in controlling heat transfer even for Ekman numbers as small as $10^{-7}$. By adding an analytical parameterization of the Ekman transport to simulations using stress-free boundary conditions, we demonstrate that the heat transfer jumps from values broadly compatible with the asymptotic theory to states of strongly increased heat transfer, in good quantitative agreement with no-slip DNS and compatible with the experimental data. Finally, similarly to non-rotating convection, we find no single scaling behavior, but instead that multiple well-defined dynamical regimes exist in rapidly-rotating convection systems.
description: Submitted to Physical Review Letters on 17 July 2014
Penguin decline - Victims, villains and heroes
Creators: name: Butterworth, Doug
Publisher: name: University of Cape Town
Year: 2023
Subjects: Biological mathematics
Applied statistics
Biostatistics

description: Doug Butterworth writes in response to a column by Melanie Verwoerd in which she reflected on the dwindling African penguin numbers, asking if the evidence is clear that it is the fishing industry that is contributing to the loss.
Theoretical and experimental evidence of non-symmetric doubly localized rogue waves
Creators: name: He, Jingsong
name: Guo, Lijuan
name: Zhang, Yongshuai
name: Chabchoub, Amin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present determinant expressions for vector rogue wave solutions of the Manakov system, a two-component coupled nonlinear Schrödinger equation. As special case, we generate a family of exact and non-symmetric rogue wave solutions of the nonlinear Schrödinger equation up to third-order, localized in both space and time. The derived non-symmetric doubly-localized second-order solution is generated experimentally in a water wave flume for deep-water conditions. Experimental results, confirming the characteristic non-symmetric pattern of the solution, are in very good agreement with theory as well as with numerical simulations, based on the modified nonlinear Schrödinger equation, known to model accurately the dynamics of weakly nonlinear wave packets in deep-water.
description: 15 pages, 7 figures, accepted by Proceedings of the Royal Society A
Consent form for A comparative study to monitor drug adherence to antihypertensive drugs among preeclamptic women and to determine factors contributing to drug compliance restrictions.
Creators: name: Agrawal, Harshita
Publisher: name: Zenodo
Year: 2023
Subjects: Preeclampsia
Antihypertensive drugs
Monitoring Drug Adherence

description: Consent form for A comparative study to monitor drug adherence to antihypertensive drugs among preeclamptic women and to determine factors contributing to drug compliance restrictions.