cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Human Placental Proteomics: Understanding the Effects of Cigarette Smoking and Cannabinoid Use
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Maternal cigarette smoking has severe negative effects on pregnancy. Little is known about how maternal tobacco use dramatically increases infertility and serious pregnancy complications. We hypothesize that smoking harms the placenta—a transient fetal organ with a lifespan matched to the length of pregnancy. Its unique functions are vital to a baby’s normal prenatal development. The unborn child must grow for many months before its organ systems are functional. During this time the placenta carries out the roles played by the heart, lungs, digestive system and kidneys after birth. Thus, toxic substances that harm the placenta also harm the child it supports in utero.

 Our group studies human placental development. One of the most important experimental tools we have is our ability to model this process in the laboratory. Previously, funded by the TRDRP, we used this model to identify specific mechanisms by which nicotine damages the placenta. Importantly, we found the same changes in the placentas of women who smoked cigarettes or were exposed to second-hand smoke during pregnancy. The results of this work were published in 5 papers.

 The experiments we now propose are based on our recent advances. First, we acquired cutting-edge global protein profiling and quantification technologies. Since proteins carry out the vast majority of biological functions, these capabilities bring us closer to linking causes and effects. Second, we discovered that human placental cells have the brain-type receptor for Δ9-tetrahydrocannabinol (Δ9-THC) that is responsible for the psychotropic effects of Cannabis. Furthermore, activating this receptor changed how placental cells function, suggesting that marijuana use during pregnancy could harm in utero development.

 Based on our previous results and new data, we now propose using global protein profiling technologies to determine the impact of nicotine ± Δ9-THC on human placental cells. The protein signatures that are associated with each exposure will be tested in our experimental model to determine how these targets alter placental functions. We envision that the results of this work will help pregnant women better understand the dangers of smoking cigarettes and marijuana during pregnancy. In addition, the information could be used to formulate new labeling requirements for nicotine- and Δ9-THC-containing products.
Données laboratoire des dates radiocarbone de la grotte de Gabillou. Laboratory data for radiocarbon dates from the Gabillou Cave.
Creators: name: Ducasse, Sylvain
name: Langlais, Mathieu
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: archéologie
Préhistoire
Chronologie
radiocarbone
Archaeology
Prehistory
chronology
Paléolithique
Magdalénien
France
Aquitaine
Dordogne
palaeolithic
Magdalenian

description: Tableau de données laboratoire des dates radiocarbone. 
Table of Laboratory data for radiocarbon dates.
Andrena (Melandrena) albifacies Alfken 1927
Creators: name: Wood, Thomas J.
name: Ismael, Halgurd R.
name: Baiocchi, Daniele
name: Hamad, Mudhafar I.
name: Bapir, Tahseen T.
name: Selis, Marco
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Andrenidae
Andrena
Andrena albifacies

description: 4.Andrena(Melandrena)albifaciesAlfken, 1927
Literature records.
Warncke (1969); Gusenleitner and Schwarz (2002: dot map 17); Grace (2010); Augul (2018); Wood and Monfared (2022); Ascher and Pickering (2023).
Remarks.
We have not examined any specimens of this species, but the presence of this species in Iraq is highly plausible based on its known global distribution, the mention of this species from southern Iraq (Warncke 1969), the map records indicated by Gusenleitner and Schwarz (2002), and the presence of this species in neighbouring Iran.
Distribution.
Morocco, Algeria, Tunisia, Libya, Egypt, Israel and West Bank, Jordan, Syria, Iraq, Iran (Warncke 1969; Gusenleitner and Schwarz 2002; Wood and Monfared 2022; Ascher and Pickering 2023).
description: Published as part of Wood, Thomas J., Ismael, Halgurd R., Baiocchi, Daniele, Hamad, Mudhafar I., Bapir, Tahseen T. & Selis, Marco, 2024, A first revision of the Andrena of Iraq (Hymenoptera, Andrenidae), with the description of two new species from Iraqi Kurdistan and additional records from surrounding countries, pp. 267-298 in ZooKeys 1205 on pages 267-298, DOI: 10.3897/zookeys.1205.120033
Cryptops Leach 1814
Creators: name: Tuf, Ivan Hadrián
name: Barjadze, Shalva
name: Maghradze, Eter
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Chilopoda
Scolopendromorpha
Cryptopidae
Cryptops

description: Key to species of Cryptops from the Caucasus
1. Tergite 1 lacks transversal suture............................................ Cryptops hortensis (Donovan, 1810)
- Tergite 1 with transversal suture......................................................................... 2
2. Tergite 1 with distinct cruciform suture..................................... Cryptops anomalans (Newport, 1844)
- Tergite 1 without cruciform suture only................................................................... 3
3. Cephalic plate, forcipular coxosternum, tergites and sternites of several anterior leg-bearing segments with dense setal sockets with short setae................................................. Cryptops anomalans hirsutus Folkmanova, 1958
- Cephalic plate, forcipular coxosternum, tergites and sternites of several anterior leg-bearing segments with only a sparse, moderately long and short setae.......................................................................... 4
4. Middle antennal articles 1.5 times longer than wide, prefemur and femur of ultimate legs 3 times longer than wide............................................................................... Cryptops caucasius Verhoeff, 1934
- Middle antennal articles 2 times longer than wide, prefemur of ultimate legs 4 times and femur 5 times longer than wide................................................................................ Cryptops datviensis sp. nov.
description: Published as part of Tuf, Ivan Hadrián, Barjadze, Shalva & Maghradze, Eter, 2022, The first troglobiotic cryptopid centipede (Chilopoda: Scolopendromorpha: Cryptopidae) from the Caucasus, pp. 436-444 in Zootaxa 5205 (5) on pages 439-440, DOI: 10.11646/zootaxa.5205.5.2, http://zenodo.org/record/7318477
Elucidating the Mechanism of Prenatal Nicotine Exposure-Induced Cardiac Defects
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoking during pregnancy is harmful to unborn babies. Exposure to smoking during tissue development can cause severe birth defects. Maternal smoking during pregnancy results in 40,000 babies born with heart diseases every year in the United States. Despite adverse consequences, approximately 20% of pregnant women still smoke in the United States. Thus, it is necessary to understand how these heart defects happen when mothers smoke during pregnancy. Yet, due to the limited access to human heart tissues and embryos, the understanding of how maternal smoking results in heart defects remains unclear. The cutting-edge technology of human-induced pluripotent stem cells (hiPSCs) enables us to investigate the pathogenic mechanism of maternal smoking-caused congenital heart diseases (CHDs).
 In this proposal, I aim to investigate the changes at the molecular level of maternal smoking-caused CHDs leveraging the iPSC technology. I will differentiate iPSCs into heart muscle cells (cardiomyocytes, CMs), the major cell type in heart tissues, to model the development of heart tissue. I will determine how CMs respond to nicotine treatment at the molecular level and identify druggable targets using this heart development model.
 The completion of this proposal will not only provide potential therapeutic targets for maternal smoking-induced CHDs through the mechanistic study but also help formulate the policies on nicotine exposure during pregnancy.
Peptide and Recombinant Allergen Vaccines for Food Allergy
Creators: name: Cook, Quindelyn S.
name: Burks, A. Wesley
Publisher: name: Springer Nature
Year: 2018

description:
Food allergy is a significant public health problem, with no suitable treatments available for patients. Currently, patients are limited to avoidance and the use of readily available emergency medications. Immunotherapy is an appealing therapeutic strategy for inducing tolerance. Studies with whole native allergens have demonstrated the efficacy of immunotherapy for food allergy; however, the risk of IgE-mediated reactions with such treatment is significant. Advances in molecular biology techniques, including purification, sequencing, and cloning, have allowed researchers to identify specific allergen components and T cell binding epitopes. Support for the use of recombinant and peptide vaccines for food allergy comes from prior studies involving aeroallergens and hymenoptera venom. By manipulating allergen structure and IgE binding, allergenicity can be reduced, thereby reducing systemic reactions, making recombinant and peptide vaccines a safe and effective form of immunotherapy. Pre-clinical studies using in vitro and murine models demonstrated a more tolerant state following the use of these therapies. Studies with human subjects will be necessary to characterize the effects of recombinant and peptide food allergy vaccines and to demonstrate a safe treatment option for patients.
Mimosa bimucronata Kuntze, Revis. Gen. Pl.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Mimosa
Mimosa bimucronata

description: 2.6 Mimosa bimucronata (DC.) Kuntze, Revis. Gen. Pl. 1: 198. 1891.
Arbustos a arvoretas, 2-7 m alt.; ramos puberulentos, armados. Estípulas 2,8-3 × 7 mm, triangulares, livres, persistentes. Folhas bipinadas, 10-pinadas; pecíolos ca. 10 mm compr., puberulentos; raque foliar ca. 30 mm compr., pubescente; foliólulos 44-48, 7-9 × 1-1,5 mm, elípticos, base oblíqua, ápice agudo a arredondado, margem inteira, faces adaxial e abaxial glabras; nectários foliares ausentes. Inflorescências capituliformes, 22-26-floras, axilares. Flores actinomorfas, pentâmeras, não ressupinadas; cálice gamossépalo, pentâmero, ca. 0,7 × 0,4 mm, campanulado, creme, glabro; corola gamopétala, ca. 2 × 1 mm, subinfundibuliforme, creme; estames 8, livres, ca. 7 mm compr., homodínamos; filetes brancos; anteras uniformes, ca. 0,1 mm, rimosas, estaminódios ausentes; ovário ca. 7 mm compr., estipitado, glabro; estilete 7 mm compr., glabro. Craspédios 3,1 × 0,7-0,8 cm, glabros, deiscentes. Sementes 3-7, circulares, 3 × 2 mm, oliváceas.
Espécie ocorrente no Paraguai, Argentina, Brasil, cultivada na Guiana e naturalizada na Jamaica, Singapura, China e África tropical (Barneby 1991). No Brasil ocorre nas regiões Norte (AC, AM), Nordeste (BA, CE, PB, PE), Centro-Oeste (DF, MT), Sudeste (ES, MG, RJ, SP) e Sul (PR), nos Domínios Fitogeográficos da Amazônia, Caatinga, Cerrado e Mata Atlântica (Silva & Tozzi 2011; BFG 2015, material suplementar). No PNMJ ocorre em Floresta Inundável, Mata Degradada e Arbustiva Fechada Não Inundável. Coletada com flores em fevereiro, maio, outubro e frutos em maio e junho.
As características diagnósticas da espécie para o PNMJ são o hábito arbustivo a arbóreo, o fruto do tipo craspédio, a inflorescência capituliforme e as flores com filetes brancos. Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema, 30. V.2012, L. A. Silva 171 (VIES); 28. VI.2012, L. A. Silva 157 (VIES); 27.X.2012, L. A. Silva 279 (VIES); 16.II.2013, L. A. Silva 345 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on pages 275-276, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
MOESM11 of A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase
Creators: name: Minkovsky, Alissa
name: Sahakyan, Anna
name: Bonora, Giancarlo
name: Damoiseaux, Robert
name: Dimitrova, Elizabeth
name: Liudmilla Rubbi
name: Pellegrini, Matteo
name: Caius Radu
name: Plath, Kathrin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Additional file 11: Figure S10. Synergistic effect of HU and 5-aza-2’dC on myeloid leukemia cell line proliferation. A. Graphs represent cell counts measured with the hemocytometer after trypan blue staining compared to viable cell number measurement determined by CellTiter-Glo reagent (Promega) for four myeloid leukemia cell lines. High correlation coefficient, R2, demonstrates linear relationship. B. Dose response curves as in Fig. 4A, except for THP1 cells using a fixed concentration ratio of 1000:1 HU:Aza. C. Dose response curves as in Fig. 4A, except for U937 cells using a fixed concentration ratio of 300:1 HU:Aza. D. Soft agar assay of K562 cells plated in DMSO or 5-aza-2’dC (0.05 uM) and/or HU (0.05 mM) in a final concentration of 3% agar and stained with crystal violet after 8 days of growth.
Mimosa caesalpiniifolia Benth., J. Bot. (Hooker
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Mimosa
Mimosa caesalpiniifolia

description: 2.7 Mimosa caesalpiniifolia Benth., J. Bot. (Hooker) 4 (31): 392. 1841.
Arbustos, ca. 3 m alt.; ramos glabros a puberulentos, armados. Estípulas 4-7,5 × 0,4 mm, estreitamente triangulares a lanceoladas, livres, persistentes. Folhas bipinadas, 6-pinadas; pecíolos 8-20 mm compr., pubescentes; raque foliar 40-56 mm compr., glabra; foliólulos 4-8, 17-44 × 9-21 mm, ovados a obovados, assimétricos, base oblíqua, ápice agudo, margem inteira, glabros; nectários foliares ausentes. Inflorescências espiciformes, ca. 144-floras, terminais. Flores actinomorfas, trímeras, não ressupinadas; cálice gamossépalo, ca. 0,5 × 0,5 mm, campanulado, branco a bege, esparso-puberulento; corola gamopétala, ca. 2 × 1 mm, campanulada, bege a branca; estames 7, livres, 6-7 mm compr., homodínamos; filetes brancos; anteras uniformes, ca. 0,4 mm compr., rimosas; estaminódios ausentes; ovário não observado. Frutos não observados.
Espécie endêmica do Brasil ocorrendo nas regiões Norte (AM, PA, RO), Nordeste (AL, BA, CE, MA, PB, PE, PI, RN), Centro-Oeste (DF, GO, MS), Sudeste (ES, MG, RJ, SP), e Sul (PR, SC), nos Domínios Fitogeográficos da Amazônia, Caatinga, Cerrado e Mata Atlântica (BFG 2015, material suplementar). No PNMJ ocorre em Área antropizada. Coletada com flores em agosto.
Esta espécie pode ser identificada pelo número de folíolulos, que variam de 4 a 8 e pela inflorescência espiciforme, com estames de filetes brancos. Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema, 29.VIII.2012, L. A. Silva 246 B (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 276, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Testing Persuasive Messages for California’s Tobacco Endgame Among Diverse & Underserved Communities
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: California’s Tobacco Endgame seeks to remove the tobacco industry’s influence and harm by 2035 through building a statewide movement that prepares communities, especially among groups that have historically been targeted by the tobacco industry, to (a) end the for-profit tobacco epidemic, (b) protect public health, and (c) eliminate tobacco-related health effects that disproportionately impact communities. For the next 13 years, this movement will take shape as tobacco control advocates, policy makers, and educators work to implement Tobacco Endgame initiatives and policies. Although these efforts are important, what is missing is an understanding of how to most effectively secure public support for the overall Tobacco Endgame goal. The purpose of this study is to develop and test Tobacco Endgame-related messages to measure support for the Tobacco Endgame Initiative among priority groups, including racial and ethnically underserved minorities, individuals with lower socio-status, and members of the LGBTQ+ community. Guided by McGuire’s Input/Output model, this study will look at how messages are more or less persuasive depending on the role of factors such as race, ethnicity, gender, age, income, and education (i.e., social determinants). Messages will be developed and tested in two stages among priority groups in California; both stages will recruit participants from an online website. During Year 1, participants (n=126) will engage in focus groups regarding the Tobacco Endgame. Focus group responses will be used to develop messages that seek to educate Californians about the importance of Endgame initiatives. In Year 2, participants (n=1,920) will complete an online survey to review the developed messages. The primary measures will assess participant knowledge, perceptions, perceived capability, and behavioral intentions regarding California’s tobacco endgame policies and initiatives. Results from this study will be shared with the tobacco prevention community, including advocates, scholars, and educators, to provide a comprehensive persuasive messaging strategy that will gain support among California’s diverse communities for the Tobacco Endgame initiative. Increased public support for tobacco policies around the state will create fewer public barriers to achieve tobacco control policy goals and, thus, making achieving the 2035 deadline feasible.
Enabling Insider Research with Priority Populations to Achieve Tobacco-Related Health Equity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Health disparities have been defined as avoidable differences in illness and/or death that hurt socially disadvantaged groups more. For example, Black and Brown communities are hurt more by the tobacco industry than whites. Nonetheless, most tobacco research has either failed to focus on these communities or it has been conducted by researchers outside of these communities, limiting the rigor and impact of the studies. Conversely, insider researchers (individuals who come from Black and Brown priority populations) improve rigor by using their community cultural wealth to improve inclusion of study participants, and by strengthening research methodology through better consideration of cultural norms and understandings. Thus, insider researchers are critical to California’s tobacco Endgame efforts, and we will prepare them through the proposed educational activities and mentored research experiences.

 The overall goal of our proposed training program is to develop insider researchers to improve understanding about local tobacco-related issues and to effect change. This is best achieved when insider researchers engage with communities to change practices and policies as shown by successful research outcomes of the SF BUILD project. This project partners San Francisco State University (SF State) and the University of California, San Francisco (UCSF) to enhance diversity of the health-related workforce. The SF BUILD infrastructure will be leveraged in the proposed activities. We will also strategically engage the Metro College Success Program (based at SF State and City College of San Francisco) and The Center for Tobacco Control Research and Education at UCSF (Research Institution). The resulting mutually beneficial collective will build upon the evidence-based approaches to inclusive and affirming classroom-based instruction and research training developed at SF State, and the internationally-recognized tobacco control research and rigorous tobacco research training program at UCSF. Taken together, these existing resources will enable SF State and transfer students from City College of San Francisco who have community cultural wealth to meaningfully engage in tobacco control studies as insider researchers to achieve health equity.
MOESM3 of MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen
Creators: name: Tagscherer, Katrin
name: Fassl, Anne
name: Sinkovic, Tabea
name: Richter, Jutta
name: Schecher, Sabrina
name: Macher-Goeppinger, Stephan
name: Roth, Wilfried
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Additional file 3: Figure S3. a CRC cell lines were transfected with an ISCU specific siRNA and a control siRNA, respectively. ROS generation was measured 48 h after transfection (left panel; mean ± SEM; n = 3; *p
Detection and Characterization of Illegal Tobacco, ENDS, and Cannabis Vaping Product Sales Online
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed project will address a critical public health challenge that is a cross-cutting issue in tobacco control and emerging patient harm: identifying and characterizing how social media and the dark web is used to market, distribute and sell unregulated and illegal Electronic Nicotine Delivery Systems (ENDS) and vaping products containing cannabis and tetrahydrocannabinol (THC) that have been identified as associated with electronic-cigarette, or vaping, product use-associated lung injury (EVALI) and adverse events (AE). We will carry out these aims by collecting and analyzing large volumes of data from popular social media platforms and dark web marketplaces with accounts that target California consumers using an advanced methodology involving data mining and machine learning. Importantly, the proposed project addresses key TRDRP research objectives that have a specific public need including research that focuses on poly tobacco and substance abuse (e.g., nicotine and cannabis), addressing the changing landscape surrounding electronic cigarettes and THC vaporizers, and cross-cutting issues of leveraging technology and driving innovation. We will first collect large volumes of data filtered for vaping and THC/marijuana product-related keywords used on multiple social media platforms and dark web posts, comments, and other messages using big data mining approaches. We will focus on vendors located and licensed in California (including cross-referencing tobacco licensed retailers and licensed marijuana dispensaries), online sellers who are discoverable using a CA Internet Protocol address, and sellers who purport to sell or ship to the state. We will then conduct in-depth analysis of illegal ENDS and marijuana vaping product sales using different machine learning and natural language processing approaches to characterize their selling tactics, marketing, and other online activity. Finally, we will characterize the scope and availability of these illegal products online while identifying specific risk factors of user groups that are exposed to this unregulated access.
Mimosa elliptica Benth., J. Bot. (Hooker
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Mimosa
Mimosa elliptica

description: 2.8 Mimosa elliptica Benth., J. Bot. (Hooker) 4 (32): 400.184 2.
Ervas, 1,2 m de alt.; ramos esparsamente pubescentes, armados. Estípulas, 5 × 1 mm, lanceoladas, livres, persistentes; folhas bipinadas, 7-10 pinas, 30-52-folioladas; pecíolos 7-8 mm compr., pubescentes; raque foliar 35-45 mm compr., pubescente a tomentosa; foliólulos 6-7 × 1 mm, elípticos, base assimétrica, ápice mucronulado, margem inteira, faces adaxial e abaxial glabras a puberulentas, pubescente na margem; nectário foliar ausente. Inflorescências capituliformes, ca. 39-floras, terminais. Flores actinomorfas, tetrâmeras, homomórficas, flores não ressupinadas; cálice gamossépalo, 0,45 × 0,25 mm, campanulado, verde, glabro; corola gamopétala; rosa, 1,4 × 1,4 mm, tubular; estames 6, livres, 7,8 mm compr., homodínamos; filetes brancos; anteras uniformes, 0,2 mm compr., rimosas; estaminódios ausentes; ovário 1 mm compr., estipitado, esparsamente puberulento; estilete 8 mm compr., glabro. Craspédios não observados.
Espécie ocorrente no Brasil e na Argentina. No Brasil ocorre nas regiões Nordeste (BA) e Sudeste (RJ, SP), nos Domínios Fitogeográficos da Mata Atlântica (BFG 2015, material suplementar). No PNMJ ocorre em área aberta não inundável. Coletada com flores em fevereiro e outubro.
Mimosa elliptica possui espinhos nos ramos, de 6-7 mm compr., pecíolos de 7-8 mm compr. Difere de Mimosa pudica por possuir espinhos menores, de cerca de 2 mm compr., menor número de pinas (4 vs. 7-10) e pecíolos maiores, com 28-33 mm de comprimento (vs. 8 mm compr.). Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL. ESPÍRITO SANTO: Parque Natural Municipal de Jacarenema: Vila Velha, 27.X.2012, L. A. Silva 285 (VIES); 17.II.2014, L. A. Silva 366 (VIES); 21.II.2014, L. A. Silva 369 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 276, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Toxicity of Recyclable Hookah Tobacco Use Waste and Recycling Behaviors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The global increase in popularity of hookah tobacco (HT), due in part to its numerous flavors, raises serious concerns about the harmful impact of its use on health, and its disposed waste on the environment. The U.S. imports of HT increased by 14%, from 738 metric tons in 2012 to 841 metric tons in 2019, providing evidence of its increased use. HT waste that may adversely impact the environment could occur from the various components involved in assembling the hookah device for smoking. We propose a novel HT study to assess toxicity of HT use waste. The hookah water pipe consists of a head, a body, a hose, and a water jar. HT is placed in the head of the water pipe and is covered with a perforated aluminum foil. Burning charcoal is placed on top of the aluminum foil. Characterization, quantification and control of HT use waste to inform limiting its level of accumulation in the environment are warranted. The aim of this study is to assess nicotine and metal contamination of HT and recyclable waste from HT use in homes of HT smokers. We will recruit 40 young adult HT smokers who usually host HT social events in their home with at least 2 HT smoker friends and family members in San Diego communities, California. At the end of one HT event, we will collect the following to characterize and quantify nicotine and metals in fresh and smoked HT use waste; quantify metals in fresh and burned hookah charcoal, and quantify nicotine on aluminum foil, and on surfaces of HT packages used for the HT social event. We will also survey participating HT smokers on tobacco use history, location of disposal of HT use waste in their homes, their HT waste recycling behaviors, and awareness of toxicity of HT use and HT use waste. Findings will inform a follow-up study aimed to design strategies to mitigate the potential adverse environmental impact of disposal of HT use waste, such as developing a HT waste recycling program with upcycling options, which does not landfill HT waste, instead turn it into fuel and energy products.
Engaging Communities in the Tobacco Endgame: Mapping Tobacco Product Litter in the Neighborhood
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: An essential approach to engaging communities in the tobacco endgame is to demonstrate the direct environmental impact of the tobacco epidemic in local neighborhoods. Traditional tobacco products (T), electronic cigarettes (E), and cannabis (C) create large quantities of non-biodegradable and toxic materials, including filters, unsmoked and charred tobacco, electronic device components, cannabis blunts, and packaging. Discarded waste accumulates on streets, parks, and beaches, flows into storm drains, and eventually ends up in waterways. TEC waste is acutely toxic to aquatic organisms and may accumulate within the human food chain. Because TEC waste is so common in all locations where humans gather, it is the most visible daily reminder that the tobacco epidemic affects all Californians. This study proposes to educate Californians about the origins and consequences of TEC waste in their communities and engage them in efforts to eliminate TEC waste as one step toward ending commercial tobacco sales by 2035. To accomplish these goals, we will (1) develop an interactive smartphone app to educate, map, record, and share observations of TEC waste distribution in local neighborhoods, (2) pilot the app with local businesses, environmental groups, and community organizations in an Adopt-a-Block study, and (3) evaluate the effectiveness of the app to increase understanding of TEC waste and engage users in efforts to finding solutions. We will test and refine the app in a sample of N=50 users from the participating organizations. This project has three significant policy implications consistent with the California Endgame Policy Platform to reduce tobacco product waste. The study will address false beliefs about tobacco filters' health benefits and harmless nature. This study will also draw attention to communities particularly affected by the tobacco epidemic and engage the public to support comprehensive tobacco control efforts. The study will contribute to pricing policies and industry-focused policies to hold producers accountable for the disposal of hazardous TEC waste. Finally, this study will provide a community-level outcome measure to track progress toward a smoke- and tobacco-free California.
Offspring effect of preconception exposure to nicotine, nicotine cessation and nicotine substitutes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The main goal of this proposal is to demonstrate whether tobacco-related exposures prior to conception lead to perturbations of how genomes are arranged in the cell nucleus of the unexposed offspring, which predispose them to metabolic disease.

 Because of the cultural and economic significance of tobacco and its adverse health outcomes, the human relationship with tobacco is complex. Smokers consume tobacco products to various extents, frequently fail quitting, and consume tobacco alternatives often in conjunction with more traditional tobacco products.

 Due to the recent decline in tobacco consumption, it is argued that in an imminent tobacco-free world we would not need to worry about tobacco-related adverse health outcomes. To spoil such rosy prospects, it is increasingly appreciated that environmental exposures can lead to adverse health outcomes in descendants of multiple generations. Whether the past widespread tobacco consumption and its lingering, specially in underserved communities, doomed the health of current and future smoke-free citizens is concerning. Much attention is directed to study whether tobacco consumption alters in utero development of smoker descendants. Less clear is whether tobacco-related exposures can lead to epigenetic alterations, i.e., perturbations that can be propagated across generations in the absence of DNA mutations, that cause or predispose to disease.

 I contributed recently to identify a new mechanism to explain how environmental exposures lead to adverse health outcomes in unexposed great-great-grand-descendants. We proposed that mouse exposure to the biocide tributyltin (TBT) leads to perturbations of nuclear genome organization (NGO) able to self-propagate and to predispose to metabolic disease across generations. I am currently establishing a new mouse model to study how preconception exposure to metabolic disruptors such as high-fat diets, TBT, or tobacco-related arsenic lead to NGO perturbations in the next generation with metabolic-disrupting and intergenerational-propagation potential, and to develop minimally-invasive cost-effective tools to diagnose such environmental NGO perturbations.

 I propose here to use this experimental model to assess whether preconception exposure to nicotine, nicotine cessation, and nicotine alternatives lead to metabolic-disrupting NGO perturbations in the next generation.
Influence of the high-risk APOL1 genotypes on tobacco-related heart disease in African Americans
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: African American people (AA) are 30% more likely to die from heart disease than Whites. Tobacco smoking (smoking) is a leading cause of heart disease, and recently AA smokers were found to be at > 2 times higher risk from heart disease than non-smokers. More than 50% of AA carry genetic variations for a component of high-density lipoproteins (HDL). HDL metabolism constitutes a crucial pathway involved in the removal of excessive cholesterol from the body and is one of the essential mechanisms supporting cardiovascular health. These genetic variations are extremely rare among Whites. Several studies reported the association of the HDL variants with increased risk for heart disease. While the magnitude of the increase in risk from tobacco varies with a presence of other factors, tobacco-related heart disease in AA has been understudied, especially in relation to these highly prevalent HDL variants.
 The goal of this research is to determine the relationship between smoking and heart disease, in particular coronary artery disease (CAD) and myocardial infarction (MI), and to identify inflammatory markers that will help determine relevant inflammatory processes, focusing on the presence of the HDL variants. To achieve this goal, I will use genomic and plasma resources, and questionnaire data from 531 AA already acquired from the UCSF Lipid Clinic. The experimental part of the project will include identification of the HDL variants at the DNA level, validation of smoking status, and measuring inflammatory markers from plasma samples. By combining experimental and questionnaire data, which includes information on CAD and MI history, we will be able to explore the association between heart disease and smoking history, and to characterize distinctive inflammatory markers, with respect to the highly prevalent HDL variants among AA. The knowledge from this research is urgently needed for a better understanding of the AA-specific genetic background that is likely increasing a risk for heart disease among AA, especially those with a smoking history, and for providing directions for targeted intervention to reduce disparities in heart disease mortality between AA and Whites.
Legacy of redlining: Policy remedies for disparities in tobacco retail density and lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer deaths in California, with a higher mortality rate for Black residents than all other racial/ethnic groups. Retailers that sell tobacco, the leading cause of lung cancer, are heavily concentrated in Black, Latino and low-income neighborhoods. This exposes residents to more tobacco advertising and lower prices, particularly for menthol cigarettes and little cigars in Black neighborhoods. However, scant research focuses on the historical and political determinants that advanced these disparities. To fill this important gap, a multidisciplinary team will investigate whether residential redlining is associated with current disparities in tobacco retailer density and lung cancer, above and beyond conventional drivers of health disparities. Newly digitized maps originally created in the 1930s by the federal Home Owners’ Loan Corporation illustrate the discriminatory practice of grading neighborhoods (A, B, C or D) on perceived mortgage investment risk based on Black, foreign-born, and low-income residents. Nearly 1 in 4 Californians now reside in the 8 cities that were graded: Fresno, Los Angeles, Oakland, Sacramento, San Diego, San Francisco, San Jose, Stockton. Aim 1 tests whether redlined tracts (grade D) have higher tobacco retailer density currently and experienced a slower annual rate of decline over time (2005-2022). With California Cancer Registry data (2016-2020), Aim 2 tests associations between: (1) redlining grades and lung cancer incidence within the 8 cities, and (2) tobacco retailer density and lung cancer incidence statewide. Analyses will adjust for population demographics and change in neighborhood gentrification. Focusing on policy solutions, Aim 3 will conduct city-specific geospatial simulation models to assess whether a combination of strategies that limit the number, type and location of tobacco retailers reduce and equalize retailer density across redlined areas within cities (pro-equity impact). Our team will engage a Community Advisory Board (CAB) of tobacco control leaders from the 8 cities and interview key stakeholders about the mechanisms through which historical redlining may impact current tobacco-related inequities to inform model predictors. CAB input will also refine city-specific dissemination products to enhance the reach and relevance of this research for state/local tobacco control.
Andrena (Truncandrena) albopicta Radoszkowski 1874
Creators: name: Wood, Thomas J.
name: Ismael, Halgurd R.
name: Baiocchi, Daniele
name: Hamad, Mudhafar I.
name: Bapir, Tahseen T.
name: Selis, Marco
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Andrenidae
Andrena
Andrena albopicta

description: 5.Andrena(Truncandrena)albopictaRadoszkowski, 1874
Literature records.
Gusenleitner and Schwarz (2002: dot map 18); Grace (2010); Augul (2018); Ascher and Pickering (2023).
Remarks.
We have not examined any specimens of this species, but the presence of this species in Iraq is plausible: the species is present in south-eastern Turkey (see specimen records presented by Wood and Monfared 2022), and the dot map presented by Gusenleitner and Schwarz (2002) seems to indicate the presence of this species in northern Iraq. It is therefore tentatively accepted as present.
Distribution.
Turkey, Armenia, Iraq, Iran (Gusenleitner and Schwarz 2002; Ascher and Pickering 2023), note that previous records from European Russia were erroneous, see Proshchalykin et al. (2023).
description: Published as part of Wood, Thomas J., Ismael, Halgurd R., Baiocchi, Daniele, Hamad, Mudhafar I., Bapir, Tahseen T. & Selis, Marco, 2024, A first revision of the Andrena of Iraq (Hymenoptera, Andrenidae), with the description of two new species from Iraqi Kurdistan and additional records from surrounding countries, pp. 267-298 in ZooKeys 1205 on pages 267-298, DOI: 10.3897/zookeys.1205.120033
Enhanced Multicomponent Proactive Navigator-Assisted Cessation of Tobacco Use in Low-Income Patients
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: California’s relatively low smoking rate (10.1%) masks deep disparities among low-income populations, where smoking rates are nearly double that of their middle- to upper-income peers. Low-income smokers report a similar desire to quit and similar rates of recent quit attempts as other smokers, yet they often face barriers in accessing effective resources that help them stay engaged in quit plans and achieve their smoking cessation goals.

 The proposed study builds upon findings from a TRDRP CPPRA pilot study (2020-2022). Dr. Jie Liu from Family Health Centers of San Diego (FHCSD), a large, urban community healthcare system that primarily serves low-income, racial and ethnic minority patients, and Dr. David Strong from the University of California San Diego will test the effectiveness of Enhanced Multicomponent Proactive Navigator-Assisted Cessation of Tobacco Use (EMPACT-Us), an innovative suite of tobacco cessation services designed in partnership with patients, providers, and other community stakeholders during the pilot study. FHCSD’s electronic health record (EHR) system will prompt health care providers to comprehensively screen for tobacco use and have more targeted conversations with patients who wish to quit. The EHR now enables bi-directional electronic referrals with Kick It California. Proactive patient navigation will help patients overcome barriers to care and improve access to tobacco cessation services such as counseling, medication, or both, as best fits their needs. Eight of FHCSD’s largest primary care clinics will be included in the study, which will compare the effectiveness of EMPACT-Us versus newly-enhanced usual care on improving engagement in tobacco treatments, quit attempts, and biochemically verified cessation at 6 and 12 months. Community engagement will continue throughout project implementation, evaluation, and the dissemination of findings. We also will explore whether EMPACT-Us is similarly effective for racial/ethnic, gender and sexual minorities, and other priority populations. The results of this study will advance health equity by equipping low-income tobacco users, who otherwise lack access to tailored cessation options, with a suite of treatment services that meet their unique needs. The study holds great promise as a ground-breaking approach to tobacco cessation care for low-income populations.
Mimosa pudica
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Mimosa
Mimosa pudica

description: 2.9 Mimosa pudica L., Sp. Pl. 1: 518. 1753. (Fig. 5O)
Ervas prostradas; ramos esparso-tomentosos a glabros, armados. Estípulas 5-6 × 2 mm compr., triangulares, livres, persistentes. Folhas bipinadas, 1-2-pinadas; pecíolos 28-33 mm compr., esparso-tomentosos a glabros; raque foliar 1-2 mm compr., esparso-tomentosa; foliólulos 28,9 × 2,4 mm, elípticos, base oblíqua, ápice agudo a arredondado, margem inteira, face adaxial glabra, face abaxial de esparso-tomentosa a esparso-puberulenta; nectários foliares ausentes. Inflorescências capituliformes, ca. 40-floras, axilares ou terminais. Flores actinomorfas, tetrâmeras, não ressupinadas; cálice gamossépalo, 0,2- 0,4 × 0,2 mm, campanulado, castanho, glabro; corola gamopétala, castanha, 1,5-2,5 × 1,2 mm, infundibuliforme a campanulada; estames 4, monadelfos, 5-7 × 0,2 mm, homodínamos, tubo estaminal 2-3 mm compr.; filetes róseos; filetes brancos; anteras uniformes, ca. 0,5 mm, rimosas; estaminódios ausentes; ovário 5-7 mm compr., glabro; estilete, 5-7 mm compr., séssil, glabro. Craspédios 1-1,7 × 0,4-0,5 cm, glabros, deiscentes. Sementes 1-2, circulares, 2,6 × 2,6 mm, pretas.
Espécie ocorrente nas Américas do Norte e do Sul, África e Ásia (Barneby 1991). No Brasil é ocorrente nas regiões Norte (AM, PA, RO, RR), Nordeste (BA), Centro-Oeste (DF, MS, MT), Sudeste (ES, MG, RJ, SP) e Sul (PR, RS, SC). Habita a Amazônia, Caatinga, Cerrado e Mata Atlântica (BFG 2015, material suplementar). No PNMJ ocorre em Área antropizada. Coletada com flores e frutos em maio.
Assemelha-se à Mimosa elliptica. Os carateres que diferenciam estas espécies foram discutidos anteriormente. Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL. ESPÍRITO SANTO: Parque Natural Municipal de Jacarenema: Vila Velha, 30.V.2012, L. A. Silva 176 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on pages 276-277, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818