cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
Creators: name: Picardi, Paola
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: MED/04 PATOLOGIA GENERALE
subject: N6-Isopentenyladenosine
subject: Angiogenesis
subject: MAPK

description: 2012 - 2013
description: N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be deregulated in cancer. iPA is an endogenous isoprenoid-derived product present in mammalian cells as a free nucleoside in the cytoplasm, or in a tRNA-bound form, displaying well established pleiotropic biological effects, including a direct anti-tumor activity against several cancers. However, the precise mechanism of action of iPA in inhibiting cancer cell proliferation remains to be clarified. In this work, we investigated whether iPA could directly interfere with the angiogenic process, fundamental to cancer growth and progression, and if the growth and proliferation of human melanoma cells, known for their highly angiogenic phenotype, could be affected by the treatment with iPA. Finally, we investigated if iPA could have an immunomodulatory role targeting directly human natural killer (NK) cells, components of innate immunity that participate in immunity against neoplastic cells, in order to provide a cooperative and multifactorial mode of action of iPA to arrest cancer growth. To evaluate the potential involvement of iPA in angiogenesis, we employed human umbilical vein endothelial cells (HUVECs) as a suitable in vitro model of angiogenesis, by evaluating the viability, proliferation, migration, invasion, tube formation, and molecular mechanisms involved. Data were corroborated in mice by using a gel plug assay. iPA dose- and time-dependently inhibited all the neoangiogenesis stages, with an IC50 of 0.98 μM. We demonstrated for the first time that iPA was monophosphorylated into iPA 5'-monophosphate (iPAMP) by adenosine kinase (ADK) inside the cells. iPAMP is the active form that inhibits angiogenesis through the direct activation of AMP-kinase (AMPK). Indeed, all effects were completely reversed by pre-treatment with 5-iodotubercidin (5-Itu), an ADK inhibitor. The isoprenoid intermediate isopentenyl pyrophosphate (IPP), which shares the isopentenyl moiety with iPA, was ineffective in the inhibition of angiogenesis, thus showing that the iPA structure is specific for the observed effects. Thus, iPA is a novel AMPK activator and could represent a useful tool for the treatment of diseases where excessive neoangiogenesis is the underlying pathology... [edited by author]
Documenting the Natural History of Patients With Resected Stage II Adenocarcinoma of the Colon After Random Assignment to Adjuvant Treatment With Edrecolomab or Observation: Results From CALGB 9581
Creators: name: Perry, Michael C.
name: Colacchio, Thomas A.
name: Mayer, Robert J.
name: Eckhardt, S. Gail
name: Niedzwiecki, Donna
name: Alberts, Steven
name: Kerr, David J.
name: O'Rourke, Mark
name: Benson, Al Bowen
name: Fields, Anthony
name: Schwartz, Joel H.
name: Porjosh, Gity N.
name: Bertagnolli, Monica M.
name: Kemeny, Nancy E.
name: Rougier, Philippe
name: Pipas, J. Marc
name: Atkins, James
name: Goldberg, Richard M.
name: Compton, Carolyn C.
name: Warren, Robert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We conducted a randomized trial comparing adjuvant treatment with edrecolomab versus observation in patients with resected, low-risk, stage II colon cancer. This study also prospectively studied patient- and tumor-specific markers of treatment outcome.
Successive spin-flop transitions of Neel-type antiferromagnet Li$_2$MnO$_3$ single crystal with honeycomb-lattice
Creators: name: Balamurugan, K.
name: Lee, Sang-Hyun
name: Kim, Jun-Sung
name: Ok, Jong-Mok
name: Jo, Youn-Jung
name: Song, Young-Mi
name: Kim, Shin-Ae
name: Choi, E. S.
name: Le, Manh Duc
name: Park, Je-Geun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have carried out high magnetic field studies of single-crystalline Li$_2$MnO$_3$, a honeycomb lattice antiferromagnet. Its magnetic phase diagram was mapped out using magnetization measurements at applied fields up to 35 T. Our results show that it undergoes two successive meta-magnetic transitions around 9 T fields applied perpendicular to the ab-plane (along the c*-axis). These phase transitions are completely absent in the magnetization measured with field applied along the ab-plane. In order to understand this magnetic phase diagram, we developed a mean-field model starting from the correct Neel-type magnetic structure, consistent with our single crystal neutron diffraction data at zero field. Our model calculations succeeded in explaining the two meta-magnetic transitions that arise when Li$_2$MnO$_3$ enters two different spin-flop phases from the zero field Neel phase.
description: 23 pages, 5 figures; Phys. Rev. B (accepted)
Future Directions in the Treatment of Neuroendocrine Tumors: Consensus Report of the National Cancer Institute Neuroendocrine Tumor Clinical Trials Planning Meeting
Creators: name: Jaffe, Deborah
name: Posner, Mitchell C.
name: Tepper, Joel E.
name: mprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Coordinating Center for Clinical Trials, Office of the Director, National Cancer Institute, Rockville, MD; Abramson Cancer Center, University of Pennsylvania; Fox...
name: Oberg, Kjell
name: Bergsland, Emily K.
name: Kulke, Matthew H.
name: Fisher, George
name: Ellis, Lee M.
name: Pingpank, James
name: Hobday, Timothy J.
name: Benedetti, Jacqueline K.
name: Yao, James C.
name: Cohen, Steven J.
name: Van Cutsem, Eric
name: Haller, Daniel G.
name: Siu, Lillian L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Neuroendocrine tumors (NETs) arise from a variety of anatomic sites and share the capacity for production of hormones and vasoactive peptides. Because of their perceived rarity, NETs have not historically been a focus of rigorous clinical research. However, the diagnosed incidence of NETs has been increasing, and the estimated prevalence in the United States exceeds 100,000 individuals. The recent completion of several phase III studies, including those evaluating octreotide, sunitinib, and everolimus, has demonstrated that rigorous evaluation of novel agents in this disease is both feasible and can lead to practice-changing outcomes. The NET Task Force of the National Cancer Institute GI Steering Committee convened a clinical trials planning meeting to identify key unmet needs, develop appropriate study end points, standardize clinical trial inclusion criteria, and formulate priorities for future NET studies for the US cooperative group program. Emphasis was placed on the development of well-designed clinical trials with clearly defined efficacy criteria. Key recommendations include the evaluation of pancreatic NET separately from NETs of other sites and the exclusion of patients with poorly differentiated histologies from trials focused on low-grade histologies. Studies evaluating novel agents for the control of hormonal syndromes should avoid somatostatin analog washout periods when possible and should include quality-of-life end points. Because of the observed long survival after progression of many patients, progression-free survival is recommended as a feasible and relevant primary end point for both phase III studies and phase II studies where a delay in progression is expected in the absence of radiologic responses.
Судьба мощей преподобного Сергия Радонежского в контексте «Мощейной эпопеи» советской власти
Creators: name: Кашеваров Анатолий Николаевич
Publisher: name: Палеоросия. Древняя Русь во времени, в личностях, в идеях
Year: 2015
Subjects: АНТИЦЕРКОВНАЯ КАМПАНИЯ
ANTI-ECCLESIASTICAL CAMPAIGN
МОЩИ ПРАВОСЛАВНЫХ СВЯТЫХ
RELICS OF THE ORTHODOX SAINTS
ПРАВОСЛАВНОЕ ДУХОВЕНСТВО
ORTHODOX CLERGY
ВЕРУЮЩИЕ
RELIGIOUS

description: Статья посвящена изучению обстоятельств осмотра и конфискации представителями советской власти мощей преподобного Сергия Радонежского в разгар кампании по вскрытию мощей православных святых, показу места этой акции в общей антицерковной политике советской власти. Особое внимание уделено попыткам православного духовенства и верующих отстоять мощи святого от конфискации и увоза из Троице-Сергиевой лавры, а также усилиям священноначалия по их возвращению Церкви в короткий период потепления государственно-церковных отношений во второй половине 1940-х годов.Article examines the circumstances of the inspection and seizure of the relics of St. Sergius of Radonezh by the Soviet authorities in the in the midst of the campaign for the opening of the relics of Orthodox saints, the place of this action in the general antiecclesiastical policy of the Soviet government. Particular attention is paid to the attempts of the Orthodox clergy and believers to defend the saint's relics from seizure and abduction from the Trinity-Sergius Lavra, as well as the efforts of the hierarchy of the Church to bring them back in a short period of warming of the church-state relations in the second half of the 1940s.
Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study
Creators: name: Weck, Karen E.
name: Anderson, Steven M.
name: Ogburn, Evan T.
name: Flockhart, David A.
name: Friedman, Kenneth J.
name: McLeod, Howard L.
name: Desta, Zeruesenay
name: Ibrahim, Joseph G.
name: Walko, Christine M.
name: Irvin, William J.
name: Canale, Sean T.
name: Corso, Steven W.
name: Carey, Lisa A.
name: Moore, Susan G.
name: Olajide, Oludamilola A.
name: Graham, Mark L.
name: Raab, Rachel E.
name: Dees, E. Claire
name: Evans, James P.
name: Chiu, Wing K.
name: Peppercorn, Jeffrey M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We examined the feasibility of using CYP2D6 genotyping to determine optimal tamoxifen dose and investigated whether the key active tamoxifen metabolite, endoxifen, could be increased by genotype-guided tamoxifen dosing in patients with intermediate CYP2D6 metabolism.
Electromechanical phase-field fracture modelling of piezoresistive CNT-based composites
Creators: name: Quinteros, L.
name: García-Macías, E.
name: Martínez-Pañeda, E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We present a novel computational framework to simulate the electromechanical response of self-sensing carbon nanotube (CNT)-based composites experiencing fracture. The computational framework combines electrical-deformation-fracture finite element modelling with a mixed micromechanics formulation. The latter is used to estimate the constitutive properties of CNT-based composites, including the elastic tensor, fracture energy, electrical conductivity, and linear piezoresistive coefficients. These properties are inputted into a coupled electro-structural finite element model, which simulates the evolution of cracks based upon phase-field fracture. The coupled physical problem is solved in a monolithic manner, exploiting the robustness and efficiency of a quasi-Newton algorithm. 2D and 3D boundary value problems are simulated to illustrate the potential of the modelling framework in assessing the influence of defects on the electromechanical response of meso- and macro-scale smart structures. Case studies aim at shedding light into the interplay between fracture and the electromechanical material response and include parametric analyses, validation against experiments and the simulation of complex cracking conditions (multiple defects, crack merging). The presented numerical results showcase the efficiency and robustness of the computational framework, as well as its ability to model a large variety of structural configurations and damage patterns. The deformation-electrical-fracture finite element code developed is made freely available to download.
Evidence of Galaxy Assembly Bias in SDSS DR7 Galaxy Samples from Count Statistics
Creators: name: Wang, Kuan
name: Mao, Yao-Yuan
name: Zentner, Andrew R.
name: Guo, Hong
name: Lange, Johannes U.
name: Bosch, Frank C. van den
name: Mezini, Lorena
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present observational constraints on the galaxy-halo connection, focusing particularly on galaxy assembly bias, from a novel combination of counts-in-cylinders statistics, $P(N_{\rm{CIC}})$, with the standard measurements of the projected two-point correlation function, $w_{\rm{p}}(r_{\rm{p}})$, and number density, $n_{\rm{gal}}$, of galaxies. We measure $n_{\rm{gal}}$, $w_{\rm{p}}(r_{\rm{p}})$ and $P(N_{\rm{CIC}})$ for volume-limited, luminosity-threshold samples of galaxies selected from SDSS DR7, and use them to constrain halo occupation distribution (HOD) models, including a model in which galaxy occupation depends upon a secondary halo property, namely halo concentration. We detect significant positive central assembly bias for the $M_r<-20.0$ and $M_r<-19.5$ samples. Central galaxies preferentially reside within haloes of high concentration at fixed mass. Positive central assembly bias is also favoured in the $M_r<-20.5$ and $M_r<-19.0$ samples. We find no evidence of central assembly bias in the $M_r<-21.0$ sample. We observe only a marginal preference for negative satellite assembly bias in the $M_r<-20.0$ and $M_r<-19.0$ samples, and non-zero satellite assembly bias is not indicated in other samples. Our findings underscore the necessity of accounting for galaxy assembly bias when interpreting galaxy survey data, and demonstrate the potential of count statistics in extracting information from the spatial distribution of galaxies, which could be applied to both galaxy-halo connection studies and cosmological analyses.
description: 16+5 pages, 9+3 figures, 5+2 tables, Fig. 6 shows the main result. To be submitted to MNRAS, comments welcome
Impact of Young Age on Treatment Efficacy and Safety in Advanced Colorectal Cancer: A Pooled Analysis of Patients From Nine First-Line Phase III Chemotherapy Trials
Creators: name: Bot, Brian M.
name: Blanke, Charles D.
name: Thomas, David M.
name: Sargent, Daniel J.
name: Seymour, Matthew T.
name: de Gramont, Aimery
name: Goldberg, Richard M.
name: Kohne, Claus-Henning
name: Bleyer, Archie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Colorectal cancer predominantly occurs in the elderly, but approximately 5% of patients are 50 years old or younger. We sought to determine whether young age is prognostic, or whether it influences efficacy/toxicity of chemotherapy, in patients with advanced disease.
Quantum estimation of Kerr nonlinearity in driven-dissipative systems
Creators: name: Xie, Dong
name: Xu, Chunling
name: Wang, An Min
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We mainly investigate the quantum measurement of Kerr nonlinearity in the driven-dissipative system. Without the dissipation, the measurement precision of the nonlinearity parameter $χ$ scales as "super-Heisenberg scaling" $1/N^2$ with $N$ being the total average number of particles (photons) due to the nonlinear generator. Here, we find that "super-Heisenberg scaling" $1/N^{3/2}$ can also be obtained by choosing a proper interrogation time. In the steady state, the "super-Heisenberg scaling" $1/N^{3/2}$ can only be achieved when the nonlinearity parameter is close to 0 in the case of the single-photon loss and the one-photon driving or the two-photon driving. The "super-Heisenberg scaling" disappears with the increase of the strength of the nonlinearity. When the system suffers from the two-photon loss in addition to the single-photon loss, the optimal measurement precision will not appear at the nonlinearity $χ=0$ in the case of the one-photon driving. Counterintuitively, in the case of the two-photon driving we find that it is not the case that the higher the two-photon loss, the lower the measurement precision. It means that the measurement precision of $χ$ can be improved to some extent by increasing the two-photon loss.
description: 8pages,5figures
Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
Creators: name: Palladino, Carmela
name: Bruno, Benedetto
name: Boccadoro, Mario
Publisher: name: Universita' degli Studi di Salerno
Year: 2014
Subjects: MGUS
Monoclonal gammopathy of undetrmined significance
Non malignant haematological disorders
Pre-malignant haematological neoplasms

description: Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular neoplasms, Waldenstrom Macroglobulinemia or light chain amyloidosis). It is a quite common finding, especially in the population above the age of 50 and it can also present in association with many non malignant conditions. Differential diagnosis of symptomatic and asymptomatic forms is the determinant for starting therapy. Over the last few years many advances in the understanding of the biology of MGUS, together with large epidemiological studies, allowed to define risk models to estimate the risk of progression to MM according to MGUS isotype and, more recently, to peculiar flow cytometry findings. The goal of many recent studies aims at evaluating individual patients and their overall risk of progression, the detection of early signs of progression and the development of timely treatment strategies.
A survey for variable young stars with small telescopes: VI -- Analysis of the outbursting Be stars NSW284, Gaia19eyy, and VES263
Creators: name: Froebrich, Dirk
name: Hillenbrand, Lynne A.
name: Herbert, Carys
name: De, Kishalay
name: Eislöffel, Jochen
name: Campbell-White, Justyn
name: Kahar, Ruhee
name: Hambsch, Franz-Josef
name: Urtly, Thomas
name: Popowicz, Adam
name: Bernacki, Krzysztof
name: Malcher, Andrzej
name: Lasota, Slawomir
name: Fiolka, Jerzy
name: Jozwik-Wabik, Piotr
name: Dubois, Franky
name: Logie, Ludwig
name: Rau, Steve
name: Phillips, Mark
name: Fleming, George
name: Farfán, Rafael Gonzalez
name: Alfaro, Francisco C. Soldán
name: Nelson, Tim
name: Futcher, Stephen R. L.
name: Rolfe, Samantha M.
name: Campbell, David A.
name: Vale, Tony
name: Devine, Pat
name: Moździerski, Dawid
name: Mikołajczyk, Przemysław J.
name: Eggenstein, Heinz-Bernd
name: Rodriguez, Diego
name: Walton, Ivan L
name: Vanaverbeke, Siegfried
name: Merrikin, Barry
name: Öğmen, Yenal
name: Perez, Alex Escartin
name: Aimar, Mario Morales
name: Piehler, Georg
name: Dover, Lord
name: Patel, Aashini L.
name: Miller, Niall
name: Finch, Jack
name: Hankins, Matt
name: Moore, Anna M.
name: Travouillon, Tony
name: Szczepanski, Marek
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: This paper is one in a series reporting results from small telescope observations of variable young stars. Here, we study the repeating outbursts of three likely Be stars based on long-term optical, near-infrared, and mid-infrared photometry for all three objects, along with follow-up spectra for two of the three. The sources are characterised as rare, truly regularly outbursting Be stars. We interpret the photometric data within a framework for modelling light curve morphology, and find that the models correctly predict the burst shapes, including their larger amplitudes and later peaks towards longer wavelengths. We are thus able to infer the start and end times of mass loading into the circumstellar disks of these stars. The disk sizes are typically 3-6 times the areas of the central star. The disk temperatures are ~40%, and the disk luminosities are ~10% of those of the central Be star, respectively. The available spectroscopy is consistent with inside-out evolution of the disk. Higher excitation lines have larger velocity widths in their double-horned shaped emission profiles. Our observations and analysis support the decretion disk model for outbursting Be stars.
description: Accepted for publication by MNRAS. 20 pages, 11 figures, 2 tables
Cross section measurement of the 144Sm(alpha,n)147Gd reaction for studying the alpha-nucleus optical potential at astrophysical energies
Creators: name: Gyürky, Gy.
name: Mohr, P.
name: Angyal, A.
name: Halász, Z.
name: Kiss, G. G.
name: Mátyus, Zs.
name: Szegedi, T. N.
name: Szücs, T.
name: Fülöp, Zs.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Nuclear reactions involving alpha particles play an important role in various astrophysical processes such as the gamma-process of heavy element nucleosynthesis. The poorly known low-energy alpha-nucleus optical (AOMP) potential is a key parameter to estimate the rates of these reactions. The AOMP can be tested by measuring the cross section of alpha-scattering as well as alpha-induced reactions. Low energy elastic alpha-scattering on 144Sm has recently been measured with high precision. The aim of the present work was to complement that work by measuring the (a,n) cross sections on 144Sm at low energies. The experimental data shall be used to constrain the AOMP. From this potential the 144Sm(a,g)148Gd reaction rate can be derived with reduced uncertainties. The 144Sm(a,n)147Gd reaction was studied by bombarding Sm targets with alpha-beams provided by the cyclotron accelerator of Atomki. The cross section was determined using the activation method. The gamma-radiation following the decay of the 147Gd reaction product was measured with a HPGe detector. The experimental data are analyzed within the statistical model. The cross section was measured in the alpha-energy range between 13 and 20 MeV in 1 MeV steps, i.e., from close above the (a,n) threshold. The results were compared with statistical model calculations using various approaches and parametrizations for the AOMP, and excellent agreement was obtained for two recent potentials. However, these potentials cannot reproduce literature data for the 144Sm(a,g)148Gd reaction with the same accuracy. Constraints for the AOMP were derived from an analysis of the new 144Sm(a,n)147Gd data and literature data for 144Sm(a,g)148Gd. These constraints enable a determination of the reaction rate of the 144Sm(a,g)148Gd reaction with significantly reduced uncertainties of less than a factor of two.
description: Accepted for publication in Phys. Rev. C
[Fe II] 1.64 um Imaging Observations of the Outflow Features around Ultracompact H II Regions in the 1st Galactic Quadrant
Creators: name: Shinn, Jong-Ho
name: Kim, Kee-Tae
name: Lee, Jae-Joon
name: Lee, Yong-Hyun
name: Kim, Hyun-Jeong
name: Pyo, Tae-Soo
name: Koo, Bon-Chul
name: Kyeong, Jaemann
name: Hwang, Narae
name: Park, Byeong-Gon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present [Fe II] 1.644 um features around ultracompact H II regions (UCHIIs) found on a quest for the "footprint" outflow features of UCHIIs---the feature produced by the outflowing materials ejected during the earlier, active accretion phase of massive young stellar objects (MYSOs). We surveyed 237 UCHIIs in the 1st Galactic quadrant, employing the CORNISH UCHII catalog and UWIFE data which is an imaging survey in [Fe II] 1.644 um performed with UKIRT-WFCAM under ~ 0.8" seeing condition. The [Fe II] features were found around five UCHIIs, one of which is of low plausibility. We interpret that the [Fe II] features are shock-excited by outflows from YSOs, and estimate the outflow mass loss rates from the [Fe II] flux, which are ~ 1 x 10^-6 - 4 x 10^-5 Ms yr^-1. We propose that the [Fe II] features might be the "footprint" outflow features, but more studies are required to clarify it. This is based on the morphological relation between the [Fe II] and 5 GHz radio features, the outflow mass loss rate, the travel time of the [Fe II] features, and the existence of several YSO candidates near the UCHIIs. The UCHIIs accompanying the [Fe II] features have a relatively higher peak flux density. The fraction of UCHIIs accompanying the [Fe II] features, 5/237, is small when compared to the ~ 90 % detection rate of high-velocity CO gas around UCHIIs. We discuss some possible explanations on the low detection rate.
description: ApJS accepted, 40 pages, 7 figures, 4 tables
The modulation of anomalous and galactic cosmic ray oxygen over successive solar cycle minima
Creators: name: Strauss, R. D.
name: Leske, R. A.
name: Rankin, J. S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Both the recent 2009 and 2020 solar minima were classified as unusually quiet and characterized with unusually high galactic cosmic ray (GCR) levels. However, unlike the trends from previous decades in which anomalous cosmic ray (ACR) and GCR levels strongly agreed, the ACR intensities did not reach such high record-setting levels.This discrepancy between the behaviour of GCRs and ACRs is investigated in this work by simulating the acceleration and transport of GCR and ACR oxygen under different transport conditions. After using recent observations to constrain any remaining free parameters present in the model, we show that less turbulent conditions are characterized by higher GCR fluxes and low ACR fluxes due to less efficient ACR acceleration at the solar wind termination shock. We offer this as an explanation for the ACR/GCR discrepancy observed during 2009 and 2020, when compared to previous solar cycles.
description: Accepted to ApJ
Evolution properties of the knot's defect
Creators: name: Morozov, A.
name: Tselousov, N.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Geometric Topology (math.GT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The defect of differential (cyclotomic) expansion for colored HOMFLY-PT polynomials is conjectured to be invariant under any antiparallel evolution and change linearly with the evolution in any parallel direction. In other words, each ${\cal R}$-matrix can be substituted by an entire 2-strand braid in two different ways: the defect remains intact when the braid is antiparallel and changes by half of the added length when the braid is parallel.
Microsatellite Instability and Loss of Heterozygosity at Chromosomal Location 18q: Prospective Evaluation of Biomarkers for Stages II and III Colon Cancer—A Study of CALGB 9581 and 89803
Creators: name: Warren, Robert S.
name: Goldberg, Richard M.
name: Saltz, Leonard B.
name: Colacchio, Thomas A.
name: Redston, Mark
name: Mayer, Robert J.
name: Compton, Carolyn C.
name: Bertagnolli, Monica M.
name: Niedzwiecki, Donna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Colorectal cancer (CRC) develops as a result of a series of accumulated genomic changes that produce oncogene activation and tumor suppressor gene loss. These characteristics may classify CRC into subsets of distinct clinical behaviors.
Spectral variations among different scenarios of PAH processing or formation
Creators: name: Maragkoudakis, A.
name: Peeters, E.
name: Ricca, A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We examine the variations in the spectral characteristics and intensities of PAHs in two different scenarios of PAH processing (or formation): (1) small PAHs are being destroyed (or equivalently large PAHs are being formed, referred to as SPR i.e. small PAHs removed), and (2) large PAHs are being destroyed (or equivalently small PAHs are being formed referred to as LPR i.e. large PAHs removed). PAH emission was measured considering both the presence or absence of plateau components. The variation in the PAH band intensities as a function of the average number of carbon atoms has the highest dynamic range in the SPR case suggesting that smaller PAHs have higher impact on the PAH band strengths. The plateaus show overall declining emission with , and their higher dynamic range in the SPR case also suggests that smaller PAHs are mainly contributing to the plateau emission. The 7.7/(11.0+11.2) $μ$m PAH band ratio presents the least amount of variance with the lowest dynamic range, rendering this ratio as the better choice for tracing PAH charge. The 3.3/(11.2+11.0) $μ$m PAH band ratio is the only ratio that has both a monotonic variance and fully separated values among the SPR and LPR scenarios, highlighting its efficiency as PAH size tracer but also allowing the characterization of the dominant scenario of processing or formation in a given region or source. We present new PAH charge $-$ size diagnostic diagrams, which can provide insights on the average, maximum, or minimum N$_{C}$ within astrophysical sources.
description: 20 pages, 14 figures, 1 table, Accepted for publication in MNRAS
Влияние русского монашества на церковную жизнь Болгарии в 1920-1940-е гг
Creators: name: Кострюков Андрей Александрович
Publisher: name: Палеоросия. Древняя Русь во времени, в личностях, в идеях
Year: 2015
Subjects: БОЛГАРСКАЯ ПРАВОСЛАВНАЯ ЦЕРКОВЬ
РУССКАЯ ПРАВОСЛАВНАЯ ЦЕРКОВЬ
РУССКАЯ ПРАВОСЛАВНАЯ ЦЕРКОВЬ ЗАГРАНИЦЕЙ
РУССКАЯ ЭМИГРАЦИЯ
АРХИЕПИСКОП СЕРАФИМ (СОБОЛЕВ)
АРХИЕПИСКОП ДАМИАН (ГОВОРОВ)
ЕРЕСЬ "ДОБРЫХ САМАРЯН"
BULGARIAN ORTHODOX CHURCH
RUSSIAN ORTHODOX CHURCH
RUSSIAN ORTHODOX CHURCH ABROAD
RUSSIAN EMIGRATION
ARCHBISHOP SERAPHIM (SOBOLEV)
ARCHBISHOP DAMIAN (GOVOROV)
THE SECT OF GOOD SAMARITANS

description: Статья посвящена влиянию русских эмигрантов и, прежде всего, монашествующих, на жизнь Болгарской Церкви. В первой половине ХХ века в Болгарской Церкви накопилось немало вопросов богословского и богослужебного характера. Серьезной проблемой был и упадок общежительного монашества. Большую роль в преодолении недостатков церковной жизни сыграли русские архипастыри, оказавшиеся в Болгарии архиепископы Серафим (Соболев) и Дамиан (Говоров). Заслугой архиепископа Серафима стало основание Покровского монастыря, борьба с церковным модернизмом и ересью «добрых самарян».The article is devoted the influence of Russian emigrants primarily monks on the life of the Bulgarian Church. In the first half of the 20th century, there were a lot of problems of theological and liturgical nature in the Bulgarian Church. The large problem was that the monkhood fell into decline. The main role in overcoming of shortcomings of the Church's life have played by archbishop Seraphim (Sobolev) and archbishop Damian (Govorov). The creation of the Pokrovsky monastery, the fight against Church modernism and the sect of Good Samaritans it's all merits of archbishop Seraphim.
Additional file 1 of A systematic review defining non-beneficial and inappropriate end-of-life treatment in patients with non-cancer diagnoses: theoretical development for multi-stakeholder intervention design in acute care settings
Creators: name: Lo, Jamie Jay-May
name: Graves, Nicholas
name: Chee, Joyce Huimin
name: Hildon, Zoe Jane-Lara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. PRISMA 2020 checklist and PRISMA 2020 for Abstracts checklist.
Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma
Creators: name: Lush, Richard M.
name: Strosberg, Jonathan R.
name: Kazi, Aslamuzzaman
name: Learoyd, Maria
name: Sullivan, Daniel M.
name: Bekaii-Saab, Tanios S.
name: Goff, Laura W.
name: Kauh, John Sae Wook
name: Sebti, Said M.
name: Lee, Ruey-min
name: O'Neil, Bert H.
name: Moore, Dominic T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Hepatocellular carcinoma (HCC) is a common and deadly malignancy with few systemic therapy options. The RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) pathway is activated in approximately 50% to 60% of HCCs and represents a potential target for therapy. Selumetinib is an orally available inhibitor of MEK tyrosine kinase activity.
The Odd Dark Matter Halos of Isolated Gas-rich Ultradiffuse Galaxies
Creators: name: Kong, Demao
name: Kaplinghat, Manoj
name: Yu, Hai-Bo
name: Fraternali, Filippo
name: Piña, Pavel E. Mancera
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze circular velocity profiles of seven ultradiffuse galaxies (UDGs) that are isolated and gas-rich. Assuming that the dark matter halos of these UDGs have a Navarro-Frenk-White (NFW) density profile or a Read density profile (which allows for constant-density cores), the inferred halo concentrations are systematically lower than the cosmological median, even as low as $-0.6$ dex (about $5σ$ away) in some cases. Alternatively, similar fits can be obtained with a density profile that scales roughly as $1/r^2$ for radii larger than a few kiloparsecs. Both solutions require the radius where the halo circular velocity peaks ($R_{\rm max}$) to be much larger than the median expectation. Surprisingly, we find an overabundance of such large-$R_{\rm max}$ halos in the IllustrisTNG dark-matter-only simulations compared to the Gaussian expectation. These halos form late and have higher spins compared to median halos of similar masses. The inner densities of the most extreme among these late-forming halos are higher than their NFW counterparts, leading to a $\sim 1/r^2$ density profile. However, the two well-resolved UDGs in our sample strongly prefer lower dark matter densities in the center than the simulated ones. Comparing to IllustrisTNG hydrodynamical simulations, we also find a tension in getting both low enough circular velocities and high enough halo mass to accommodate the measurements. Our results indicate that the gas-rich UDGs present a significant challenge for galaxy formation models.
description: 21 pages, 18 figures, accepted for publication in ApJ
Development of polygon forming processes for aerospace engineering
Creators: name: Müller, Philipp
name: Behrens, Bernd-Arno
name: Hübner, Sven
name: Jepkens, Jan
name: Wester, Hendrik
name: Lautenbach, Sven
Publisher: name: Millersville, PA : Materials Research Forum LLC
Year: 2023
Subjects: subject: Aluminum
subject: Polygon Forming
subject: Sheet Metal
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: The focus of this research lays on the further development of the Polygon Forming Technology, which is already successfully used for cold forming components in the aerospace industry. One example is the fuselage shell of the Airbus Beluga XL. According to the current state of the art it is possible to incrementally form large cylindrical or conical fuselage components by Polygon Forming. With the use of so-called infills, the Polygon Forming process can also be used to form components with pockets milled in the initial plane state. The limits of this technology exclude the creation of spherical geometries, such as those used in the front or rear fuselage sections of aircrafts. Presently, such components are produced by more complex stretch forming processes, which result in a considerable amount of scrap. In this work, a tool is developed to replicate the Polygon Forming process on experimental scale at the Institute of Forming Technology and Machines (IFUM) for materials commonly used in aerospace engineering. In addition, a downscaled pre-test tool is developed to investigate different tool geometries for incremental spherical forming inexpensive and easy according to the method of rapid prototyping.
Chaotic instability in the BFSS matrix model
Creators: name: Fukushima, Osamu
name: Yoshida, Kentaroh
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Chaotic scattering is a manifestation of transient chaos realized by the scattering with non-integrable potential. When the initial position is taken in the potential, a particle initially exhibits chaotic motion, but escapes outside after a certain period of time. The time to stay inside the potential can be seen as lifetime and this escape process may be regarded as a kind of instability. The process of this type exists in the Banks-Fischler-Shenker-Susskind (BFSS) matrix model in which the potential has flat directions. We discuss this chaotic instability by reducing the system with an ansatz to a simple dynamical system and present the associated fractal structure. We also show the singular behavior of the time delay function and compute the fractal dimension. This chaotic instability is the basic mechanism by which membranes are unstable, which is also common to supermembranes at quantum level.
description: 17 pages, 11 figures, figures added, minor improvements
Duplicate Table Detection with Xash
Creators: name: Koch, Maximilian
name: Esmailoghli, Mahdi
name: Auer, Sören
name: Abedjan, Ziawasch
Publisher: name: Bonn : Ges. für Informatik
Year: 2023
Subjects: subject: data discovery
subject: data lakes
subject: duplicate table detection
subject: Konferenzschrift
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: Data lakes are typically lightly curated and as such prone to data quality problems and inconsistencies. In particular, duplicate tables are common in most repositories. The goal of duplicate table detection is to identify those tables that display the same data. Comparing tables is generally quite expensive as the order of rows and columns might differ for otherwise identical tables. In this paper, we explore the application of Xash, a hash function previously proposed for the discovery of multi-column join candidates, for the use case of duplicate table detection. With Xash, it is possible to generate a so-called super key, which serves like a bloom filter and instantly identifies the existence of particular cell values. We show that using Xash it is possible to speed up the duplicate table detection process significantly. In comparison to SimHash and other competing hash functions, Xash results in fewer false positive candidates.
Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B
Creators: name: Zhao, Ming
name: O'Rourke, Joseph G.
name: Wright, Jason T.
name: Knutson, Heather A.
name: Burrows, Adam
name: Fortney, Johnathan
name: Ngo, Henry
name: Fulton, Benjamin J.
name: Baranec, Christoph
name: Riddle, Reed
name: Law, Nicholas M.
name: Muirhead, Philip S.
name: Hinkley, Sasha
name: Showman, Adam P.
name: Curtis, Jason
name: Burruss, Rick
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/WIRC in H and Ks bands and with Spitzer/IRAC at 3.6 and 4.5 micron. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.923" +/- 0. 004" and a position angle 110.64 deg +/- 0.12 deg. We measure the flux ratios of the binary in g' r' i' z' and H & Ks bands, and determine Teff = 3565 +/- 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090 +/- 0.033%, 0.178 +/- 0.057%, 0.364 +/- 0.016%, and 0.438 +/- 0.020% in the H, Ks, 3.6 and 4.5 micron bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well-described by a blackbody model for the planet with Tp = 2042 +/- 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 +/- 1.3 min from the predicted mid-eclipse time, which constrains e = 0.0072 +0.0700/-0.0064 when combined with RV data and is more consistent with a circular orbit.
description: 16 pages, 12 figures. Accepted for publication in ApJ
«Подвиг св. Сергия Радонежского и дело митрополита Сергия»: к вопросу об оправданности сопоставления
Creators: name: Мазырин Александр
Publisher: name: Палеоросия. Древняя Русь во времени, в личностях, в идеях
Year: 2015
Subjects: РУССКАЯ ПРАВОСЛАВНАЯ ЦЕРКОВЬ
RUSSIAN ORTHODOX CHURCH
ЦЕРКОВНОГОСУДАРСТВЕННЫЕ ОТНОШЕНИЯ
CHURCH-STATE RELATIONS
МОНГОЛЬСКОЕ ИГО
THE MONGOL YOKE
РУССКОЕ ЗАРУБЕЖЬЕ
RUSSIAN DIASPORA

description: В статье рассматривается вопрос об уместности допускавшегося в церковной полемической литературе 1920-1930-х гг. уподобления компромисса с советской властью Заместителя Патриаршего Местоблюстителя митрополита Сергия (Страгородского) позиции преподобного Сергия Радонежского и таких его современников, как св. митрополит Алексий, в отношении ордынских завоевателей. Делается вывод, что проводить такие сопоставления не очень оправдано.The article deals with the question of the appropriateness allowed in the church polemical literature of 1920-1930. assimilation of the compromise with the Soviet authorities from vice Patriarch locum tenens Metropolitan Sergius (Stragorodsky) with the position of Sergius of Radonezh and his contemporaries such as St. Metropolitan Alexy, in respect of the Horde invaders. It is concluded that it is not very justified to make such comparison.
Additional file 2 of A systematic review defining non-beneficial and inappropriate end-of-life treatment in patients with non-cancer diagnoses: theoretical development for multi-stakeholder intervention design in acute care settings
Creators: name: Lo, Jamie Jay-May
name: Graves, Nicholas
name: Chee, Joyce Huimin
name: Hildon, Zoe Jane-Lara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. Reference list for Tables 2, 3, 4 citations and study characteristics.
Time reversal and $\boldsymbol{CP}$ invariance in Calabi-Yau compactifications
Creators: name: Bönisch, Kilian
name: Elmi, Mohamed
name: Kashani-Poor, Amir-Kian
name: Klemm, Albrecht
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit the question of time reversal and $CP$ invariance in Calabi-Yau compactifications. We show that time reversal invariance is respected by quantum corrections to the prepotential. In particular, field independent $θ$ angles whose presence is dictated by requiring integrality of relevant monodromy transformations can take precisely the quantized values compatible with time reversal invariance. Furthermore, monodromy symmetry enlarges the region on moduli space on which time reversal is not spontaneously broken. We define the action of the $CP$ transformation for multi-parameter models and argue that on the slice of moduli space where it is defined, $CP$ is trivially a symmetry of the theory. For supersymmetric vacua that lie in this slice, we derive a condition on the third cohomology of the compactification manifold which determines whether $CP$ preserving fluxes exist that stabilize the moduli to such points. In the case of one-parameter models, the condition is always satisfied.
description: 45 pages
Modelling of an induction heating process and resulting material distribution of a hybrid semi-finished product after impact extrusion
Creators: name: Behrens, Bernd-Arno
name: Wester, Hendrik
name: Schäfer, Stefan
name: Büdenbender, Christoph
Publisher: name: Liège : ULiège Library
Year: 2021
Subjects: subject: Finite element method
subject: Induction heating
subject: Tailored forming
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::670 | Industrielle und handwerkliche Fertigung

description: Multi-material solutions offer benefits, as they, in contrary to conventional monolithic parts, are customised hybrid components with properties that optimally fit the application locally. Adapted components offer the possibility to use high strength material in areas where external loads require it and substitute them by lightweight material in the other areas. The presented study describes the manufacturing of a hybrid shaft along the process chain Tailored Forming, which uses serial pre-joined semi-finished products in the forming stage. Subject of this study is the numerical modelling of the heating process by induction heating of a hybrid semi-finished product and the resulting material distribution after the impact extrusion process. For this endeavour, a numerical model of an inhomogeneous induction heating process was developed. The main challenge is to determine the boundary conditions such as current intensity acting in the induction coil and the electromagnetic properties of the used material. The current intensity was measured by a Rogowski coil during experimental heating tests. The relative magnetic permeability was modelled as a function of temperature using the method of Zedler. The results show the importance of using a relative magnetic permeability as a function of temperature to guarantee a high quality of the numerical model. Subsequently, the model was applied to the heating of the hybrid semi-finished product consisting of a steel and aluminium alloy. By using inductive heating and thus a resulting inhomogeneous temperature field, good agreement of the material distribution between experiment and simulation could be achieved after the forming process.
Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08
Creators: name: O'Connell, Michael J.
name: Yothers, Greg
name: Colangelo, Linda H.
name: Sharif, Saima
name: Atkins, James N.
name: Wolmark, Norman
name: Chu, Luis
name: O'Reilly, Seamus
name: Petrelli, Nicholas J.
name: Seay, Thomas E.
name: Allegra, Carmen J.
name: Goldberg, Richard M.
name: Azar, Catherine A.
name: Lopa, Samia
name: Fehrenbacher, Louis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The National Surgical Adjuvant Breast and Bowel Project C-08 trial was designed to investigate the safety and efficacy of adding bevacizumab to modified FOLFOX6 (mFOLFOX6; ie, infusional/bolus fluorouracil, leucovorin, and oxaliplatin) for the adjuvant treatment of patients with stages II to III colon cancer.