cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Evidence for validity of the Swedish self-rated 36-item version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in patients with mental disorders: a multi-centre cross-sectional study using Rasch analysis
Creators: name: Svanborg, Cecilia
name: Amer, Ahmed
name: Nordenskjöld, Axel
name: Ramklint, Mia
name: Söderberg, Per
name: Tungström, Stefan
name: Ginsberg, Ylva
name: Hermansson, Liselotte
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Figure S2. Rating scale category structure for the Swedish WHODAS 2.0 in psychiatric patients.
Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study
Creators: name: O’Hearn, Katie
name: MacDonald, Cameron
name: Tsampalieros, Anne
name: Kadota, Leo
name: Sandarage, Ryan
name: Jayawarden, Supun Kotteduwa
name: Datko, Michele
name: Reynolds, John M.
name: Bui, Thanh
name: Sultan, Shagufta
name: Sampson, Margaret
name: Pratt, Misty
name: Barrowman, Nick
name: Nama, Nassr
name: Page, Matthew
name: McNally, James D.
Publisher: name: BioMed Central
Year: 2021

description: Background Standard practice for conducting systematic reviews (SRs) is time consuming and involves the study team screening hundreds or thousands of citations. As the volume of medical literature grows, the citation set sizes and corresponding screening efforts increase. While larger team size and alternate screening methods have the potential to reduce workload and decrease SR completion times, it is unknown whether investigators adapt team size or methods in response to citation set sizes. Using a cross-sectional design, we sought to understand how citation set size impacts (1) the total number of authors or individuals contributing to screening and (2) screening methods. Methods MEDLINE was searched in April 2019 for SRs on any health topic. A total of 1880 unique publications were identified and sorted into five citation set size categories (after deduplication): < 1,000, 1,001–2,500, 2,501–5,000, 5,001–10,000, and > 10,000. A random sample of 259 SRs were selected (~ 50 per category) for data extraction and analysis. Results With the exception of the pairwise t test comparing the under 1000 and over 10,000 categories (median 5 vs. 6, p = 0.049) no statistically significant relationship was evident between author number and citation set size. While visual inspection was suggestive, statistical testing did not consistently identify a relationship between citation set size and number of screeners (title-abstract, full text) or data extractors. However, logistic regression identified investigators were significantly more likely to deviate from gold-standard screening methods (i.e. independent duplicate screening) with larger citation sets. For every doubling of citation size, the odds of using gold-standard screening decreased by 15 and 20% at title-abstract and full text review, respectively. Finally, few SRs reported using crowdsourcing (n = 2) or computer-assisted screening (n = 1). Conclusions Large citation set sizes present a challenge to SR teams, especially when faced with time-sensitive health policy questions. Our study suggests that with increasing citation set size, authors are less likely to adhere to gold-standard screening methods. It is possible that adjunct screening methods, such as crowdsourcing (large team) and computer-assisted technologies, may provide a viable solution for authors to complete their SRs in a timely manner.
title: The training of governors, headteachers and senior staff in preparation for Local Management of Schools (LMS) with particular reference to financial management
Creators: name: Varnon, Nicholas Charles Harbord
Publisher: name: The Open University
Year: 1991

description: The Education (Number 2) Act 1986 and the Education Reform Act 1988 transferred and increased the responsibility for the management of schools from Local Education Authorities to school governing bodies: "Local Management of Schools". In managing, governing bodies would remain partially accountable to Local Authorities and HMI in terms of National Curriculum delivery, and to Local Authorities in the auditing of their use of budget resources. The introduction of a wider accountability to the local community, focused on the annual report to parents, would increase responsibility. Transferred and increased responsibility requires governing bodies, headteachers and senior staff to acquire the knowledge, skills and attitudes (management attributes) necessary to manage effectively, carry out responsibilities and account for their management record. The strategies adopted to provide for the acquisition of management attributes were designed by Local Authorities as a short-term response to the immediate needs of school managers: this was management "training". The strategies, content and processes of providing management training are analysed and assessed, focusing on the first two years of Local Management implementation (1988 to 1990). Financial management training is of particular interest. For the longer-term continuity of management, training will contribute to, but not entirely provide, adequate support for governors, headteachers and senior staff at 'Authority level'. Managers will need to acquire attributes of self-analysis, identifying the organisational management needs which require client-orientated support programmes; this is management "development". Recommendations are presented to effect a change from management "training" to management "development", the Authorities no longer being the automatic providers but acting more as development agencies.
Additional file 4 of Evidence for validity of the Swedish self-rated 36-item version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in patients with mental disorders: a multi-centre cross-sectional study using Rasch analysis
Creators: name: Svanborg, Cecilia
name: Amer, Ahmed
name: Nordenskjöld, Axel
name: Ramklint, Mia
name: Söderberg, Per
name: Tungström, Stefan
name: Ginsberg, Ylva
name: Hermansson, Liselotte
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Table S2. Conversion of total raw scores to Rasch scaled scores for the Swedish self-rated 36-item WHODAS 2.0.
Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease
Creators: name: Chen, Tao
name: Tsai, Amy Po Yu
name: Hur, Seo Am
name: Wong, Alyson
name: Sadatsafavi, Mohsen
name: Fisher, Jolene H.
name: Johannson, Kerri A.
name: Assayag, Deborah
name: Morisset, Julie
name: Shapera, Shane
name: Khalil, Nasreen
name: Fell, Charlene D.
name: Manganas, Helene
name: Cox, Gerard
name: To, Teresa
name: Gershon, Andrea S.
name: Hambly, Nathan
name: Halayko, Andrew J.
name: Wilcox, Pearce
name: Kolb, Martin
name: Ryerson, Christopher J.
Publisher: name: BioMed Central
Year: 2021

description: Rationale The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum important difference (MID) in fibrotic interstitial lung disease (ILD). We aimed to describe the key performance characteristics of the UCSDSOBQ in this population. Methods UCSDSOBQ scores and selected anchors were measured in 1933 patients from the prospective multi-center Canadian Registry for Pulmonary Fibrosis. Anchors included the St. George’s Respiratory Questionnaire (SGRQ), European Quality of Life 5 Dimensions 5 Levels questionnaire (EQ-5D-5L) and EQ visual analogue scale (EQ-VAS), percent-predicted forced vital capacity (FVC%), diffusing capacity of the lung for carbon monoxide (DLCO%), and 6-min walk distance (6MWD). Concurrent validity, internal consistency, ceiling and floor effects, and responsiveness were assessed, followed by estimation of the MID by anchor-based (linear regression) and distribution-based methods (standard error of measurement). Results The UCSDSOBQ had a high level of internal consistency (Cronbach’s alpha = 0.97), no obvious floor or ceiling effect, strong correlations with SGRQ, EQ-5D-5L, and EQ-VAS (|r| > 0.5), and moderate correlations with FVC%, DLCO%, and 6MWD (0.3 < |r| < 0.5). The MID estimate for UCSDSOBQ was 5 points (1–8) for the anchor-based method, and 4.5 points for the distribution-based method. Conclusion This study demonstrates the validity of UCSDSOBQ in a large and heterogeneous population of patients with fibrotic ILD, and provides a robust MID estimate of 5–8 points.
Additional file 1 of Combining nucleotide variations and structure variations for improving astaxanthin biosynthesis
Creators: name: Jin, Jin
name: Jia, Bin
name: Yuan, Ying-Jin
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Plasmids used in this study. Table S2. Primers used in this study. Table S3. Variations in YSA103, YSA104 and YSA105 with respect to YSA001. Table S4. Transcriptional analyses of genes in MVA pathway of YJR116W deletion strain YSA448. Figure S1. The volcano plot of transcriptome of YJR116W deletion strain YSA448. No-differentially expressed genes are shown in gray, up expressed genes are shown in red and down genes are shown in blue. Figure S2. Plasmid map of CRISPR/Cas9 were expression with two gRNA used in this study. Figure S3. The HPLC separation results of astaxanthin standards and products of YSA001. Figure S4. ESI scan for astaxanthin by LC–MS.
Additional file 1 of Perceptions towards childhood asthma and barriers to its management among patients, caregivers and healthcare providers: a qualitative study from Ethiopia
Creators: name: Kassa, Eden
name: Kebede, Rahel Argaw
name: Habte, Bruck Messele
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Interview guide for patients and caregivers.
Additional file 2 of Perceptions towards childhood asthma and barriers to its management among patients, caregivers and healthcare providers: a qualitative study from Ethiopia
Creators: name: Kassa, Eden
name: Kebede, Rahel Argaw
name: Habte, Bruck Messele
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Interview guide for the healthcare providers.
Additional file 1 of Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
Creators: name: López-Cano, Adrià
name: Martínez-Miguel, Marc
name: Guasch, Judith
name: Ratera, Imma
name: Arís, Anna
name: Garcia-Fruitós, Elena
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Bacterial survival of P. aeruginosa in the presence and absence of 5 μM of soluble GFP-H6. Figure S2. Antimicrobial activity of soluble HD5-GFP-H6 (dark grey) and synthetic HD5 (light grey) against MRSA and P. aeruginosa. Different letters indicate statistical differences between tested strains and proteins P = 0.0001.
Additional file 1 of A scoping review on women’s sexual health in the postpartum period: opportunities for research and practice within low-and middle-income countries
Creators: name: Wood, Shannon N.
name: Pigott, Alexandria
name: Thomas, Haley L.
name: Wood, Chloe
name: Zimmerman, Linnea A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. PubMed MeSH Terms
Pubblicare: la parola ai ricercatori (Publishing Open)
Creators: name: Sarretta, Alessandro
Publisher: name: Zenodo
Year: 2019
Subjects: open science
open access
scholarly publishing

description: Presentazione all'interno del seminario "Servizi e strumenti per la ricerca a Ca’ Foscari". 29 maggio 2019 ore 9.15 – 14.30. Aula Morelli, Palazzo Malcanton Marcorà, Venezia (https://www.unive.it/data/agenda/11/29128)
Additional file 1 of Trace amounts of antibiotic altered metabolomic and microbial profiles of weaned pigs infected with a pathogenic E. coli
Creators: name: Kim, Kwangwook
name: Jinno, Cynthia
name: Ji, Peng
name: Liu, Yanhong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Fig. S1. Partial Least Squares Discriminant Analysis (PLS-DA) 2D score plot of the metabolites in serum revealed significant differences on d 0 before E. coli challenge, d 5 and 11 post-inoculation between the TRA and REC groups (A-C) and CON and REC (D-E), respectively. ● = CON (Control); ● = TRA (Trace amounts of antibiotic); ● = REC (Label-recommended dose of antibiotic). Shaded areas in different colors represent in 95% confidence interval. Fig. S2. Significantly changed pathways in serum between the control (CON) and label-recommended dose of antibiotic (REC) groups (A), and trace amounts of antibiotic (TRA) and REC groups (B) on d 0 before E. coli challenge. The x-axis represents the pathway impact values and the y-axis represents the -log(P) values from the pathway enrichment analysis. Metabolite set enrichment analysis (C, D) shows the metabolic pathways were enriched in CON compared to REC, and TRA compared to REC on d 0 before E. coli challenge, respectively. Both pathway analysis and metabolite set enrichment analysis were performed using identified metabolites with VIP > 1. Fig. S3. Significantly changed pathways in serum between the control (CON) and label-recommended dose of antibiotic (REC) groups (A), and trace amounts of antibiotic (TRA) and REC groups (B) on d 11 post-inoculation. The x-axis represents the pathway impact values and the y-axis represents the -log(P) values from the pathway enrichment analysis. Metabolite set enrichment analysis (C, D) shows the metabolic pathways were enriched in CON compared to REC, and TRA compared to REC on d 11 post-inoculation, respectively. Both pathway analysis and metabolite set enrichment analysis were performed using identified metabolites with VIP > 1. Fig. S4. Partial Least Squares Discriminant Analysis (PLS-DA) 2D score plot of the metabolites in colon digesta revealed significant differences between the TRA and REC groups on d 5 (A) and 11 (B) post-inoculation. ● = TRA (Trace amounts of antibiotic); ● = REC (Label-recommended dose of antibiotic). Shaded areas in different colors represent in 95% confidence interval. Fig. S5. Alpha diversity as indicated by Chao 1 (A) and Shannon (B) indices in colon digesta of enterotoxigenic E. coli F18 challenged pigs fed diets supplemented with different dose of antibiotic on d 5 and 11 post-inoculation. a-bMeans without a common superscript are different across both time points (Diet × day, P
Researchers’ perspectives on methodological challenges and outcomes selection in interventional studies targeting medication adherence in rheumatic diseases: an OMERACT-adherence study
Creators: name: Salmasi, Shahrzad
name: Kelly, Ayano
name: Bartlett, Susan J.
name: De Wit, Maarten
name: March, Lyn
name: Tong, Allison
name: Tugwell, Peter
name: Tymms, Kathleen
name: Verstappen, Suzanne
name: De Vera, Mary
Publisher: name: BioMed Central
Year: 2021

description: Background Research on adherence interventions in rheumatology is limited by methodological issues, particularly heterogeneous outcomes. We aimed to describe researchers’ experiences with conducting interventional studies targeting medication adherence in rheumatology and their perspectives on establishing core outcomes. Methods Semi-structured interviews using audio conference were conducted with researchers who had conducted an adherence study of any design in the past 10 years. Data collection and thematic analysis were performed iteratively, until saturation. Results We interviewed 13 researchers, most of whom worked in academia and specialized in epidemiology and/or health services research. We identified three themes: 1) improving measurement of adherence (considering all phases of adherence, using appropriate and relevant measures, and establishing clinically meaningful thresholds); 2) challenges in designing and appraising adherence intervention studies (considering the confusion over a plethora of outcomes, difficulties with powering studies to demonstrate meaningful changes, and suboptimal descriptions of adherence interventions in published studies); and 3) advancing outcome assessment in adherence intervention studies (capturing rationale for developing a core domain set as well as recommendations and anticipated challenges by participants). Conclusions Uniquely gathering perspectives from international adherence researchers, our findings led to researcher-informed recommendations for improving adherence research including specifying the targeted adherence phase in designing interventions and studies and providing a glossary of terms to promote consistency in reporting. We also identified recommendations for developing a core domain set for interventional studies targeting medication adherence including involvement of patients, clinicians, and other stakeholders and methodological and practical considerations to establish rigor and support uptake.
INTERIM IMPACT REPORT ON SUPPORT FOR EU PARTICIPATION IN RDA
Creators: name: Biro, Timea
name: Harrower, Natalie
Publisher: name: Zenodo
Year: 2019
Subjects: RDA, Research Data Alliance, Early Careers, Experts, RDA Ambassadors, RDA Plenaries

description: The present deliverable outlines the work of the RDA EU project on the programmes designed to support the participation in RDA processes including activities of the Working and Interest groups, the RDA working meetings and workshops. In particular, under the project WP2 “Support to European participation in RDA processes”, RDA Europe has developed and sustained three different platforms to engage and support the EU individual participation to RDA. Two of the programmes have a particular focus on supporting participation to the RDA working meetings, the RDA Plenaries, and the work of the RDA groups, for two specific categories of RDA membership: Experts and the Early Careers. The third programme developed, the one dedicated to the Ambassadors, was, on the other hand, aimed at supporting participation by engaging specific discipline communities and building a two communication channel streamlining RDA outputs and contributions to domain communities and ensuring their vice-versa input in terms of requirements and best practices into the RDA. This document outlines the different support programmes, the results and aspects related to the impact of these in relation to the RDA Europe 4.0 objectives.
Study 4 Vaccine Effectiveness Explanation & Vaccine Hesitancy Study
Creators: name: Burgeno, Jessica Noel
name: Joslyn, Susan
name: Qin, Chao
name: Vi Tran
name: Savelli, Sonia
name: Han, Jee Hoon
name: Agrawal, Nidhi
Publisher: name: OSF
Year: 2021

description: Two COVID-19 vaccines that have been shown to be about 95% effective are now available. However, surveys have shown that many people are reluctant to get vaccinated (30% in May 2020 study conducted by Reiter, Pennell, & Katz, 2020). Recent research suggests that there are several reasons for COVID-19 vaccine hesitancy. Several of these have to do with specific misunderstandings, including:
1) How the vaccine works
2) The potential side effects of the vaccine
3) Sufficiency of testing
4) What 95% effectiveness means

Previous research suggests that simple explanations of complex issues such as climate change can increase understanding if they are designed to target known misunderstandings. These same explanations were shown to change peoples’ attitudes toward the efficacy of strategies to combat climate change. If the same principles operate in the context of COVID19, carefully designed explanations may dispel misunderstandings as well as encourage more people to get vaccinated.

This study provides an explanation that addresses a misunderstanding concerning the effectiveness of the Pfizer and Moderna COVID-19 vaccines. The effectiveness manipulations are focused on people’s mental models or understanding of what it means to be “95% effective.” We focus here on issues related to of the vaccine itself rather than the effects of COVID (some do not believe the disease is sufficiently dangerous to take any risks to protect against it). We do not address conspiracy theories.
Additional file 1 of Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan
Creators: name: Mukry, Samina Naz
name: Shahni, Aneeta
name: Zaidi, Uzma
name: Sultan Shamsi, Tahir
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Impact of combination of multiple polymorphic defects in different DME genes on occurrence of CML.
Forschendes Lernen als Hochschulreform? Zum 50-Jahr-Jubiläum der Programmschrift der Bundesassistentenkonferenz
Creators: name: Reinmann, Gabi (Herausgeber/in der Reihe)
name: Tremp, Peter (Herausgeber/in)
Publisher: name: Zenodo
Year: 2020
Subjects: Forschendes Lernen
BAK-Schrift
Deutsche Gesellschaft für Hochschuldidaktik
Bundesassistentenkonferen BAK

description: Vor 50 Jahren erschien erstmals die Schrift «Forschendes Lernen – Wissenschaftliches Prüfen der damaligen Bundesassistentenkonferenz BAK. Ein exzeptioneller Erfolg.» Eine Publikation präsentiert nun ausgewählte Überlegungen, welche anlässlich der beiden Jahrestagungen der Deutschen Gesellschaft für Hochschuldidaktik und der Gesellschaft für Hochschulforschung im März 2020 (und also im Jubiläumsjahr der BAK-Schrift) präsentiert und diskutiert werden sollten – und antwortet damit auf das grosse Interesse, das dieser Gesprächsrunden bereits im Vorfeld entgegengebracht wurde.
description: + ID der Publikation: phlu_12390 + Art des Beitrages: Journal/Magazin + Sprache: Deutsch + Letzte Aktualisierung: 2020-09-15 13:56:53
Computational Complexity Studies on the Robust Design and Scheduling of Chemical Batch Processes
Creators: name: de Miranda, Joao Luis
Publisher: name: Zenodo
Year: 2020
Subjects: Computational complexity;
design and scheduling;
chemical batch processes;
robust optimization;
supply chains

description: The design and scheduling of chemical batch process (DSCBP) is a very well studied problem, due to the wide application in multiple industry sectors, for example, in agri-food, fine chemicals, food specialties, and pharmaceutical. Multi Criteria Decision Making (MCDM) tools are also utilized to address the agri-food supply chains, dealing with uncertainty, coping with computational issues, and developing robust optimization (RO) models. At present, the enlarged version of the problem MS (multiple machines and SPC policy) is shown to be NP-hard in the strong sense: the robust problem RObatch_MS. In this way, heuristics and approximation procedures can be strong options to effectively address these enlarged DSCBP problems, while polynomial algorithms to exactly solve them can be neglected. These computational complexity studies can support innovative approaches and methodologies, improve modeling techniques and solving approaches for agri-food supply chains, while promoting robustness both on models and on solutions.
description: The Author thanks: COST Action CA15118 Mathematical and Computer Science Methods for Food Science and Industry (FoodMC), supported by COST (European Cooperation in Science and Technology); Escola Superior de Tecnologia e Gestão, Instituto Politécnico de Portalegre (ESTG/IPP); and Centro de Recursos Naturais e Ambiente, Instituto Superior Técnico (CERENA/IST) within the support of FCT-Fundação para a Ciência e a Tecnologia through the strategic project FCT-UID/ECI/04028/2020
Classification of Landforms for Digital Soil Mapping in Urban Areas Using LiDAR Data Derived Terrain Attributes: A Case Study from Berlin, Germany
Creators: name: Mohamed, Mohamed Ali
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: digital soil mapping
subject: landforms classification
subject: morphometric attributes
subject: LiDAR data
subject: Berlin
subject: 550 Geowissenschaften

description: In this study, a knowledge-based fuzzy classification method was used to classify possible soil-landforms in urban areas based on analysis of morphometric parameters (terrain attributes) derived from digital elevation models (DEMs). A case study in the city area of Berlin was used to compare two different resolution DEMs in terms of their potential to find a specific relationship between landforms, soil types and the suitability of these DEMs for soil mapping. Almost all the topographic parameters were obtained from high-resolution light detection and ranging (LiDAR)-DEM (1 m) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER)-DEM (30 m), which were used as thresholds for the classification of landforms in the selected study area with a total area of about 39.40 km2. The accuracy of both classifications was evaluated by comparing ground point samples as ground truth data with the classification results. The LiDAR-DEM based classification has shown promising results for classification of landforms into geomorphological (sub)categories in urban areas. This is indicated by an acceptable overall accuracy of 93%. While the classification based on ASTER-DEM showed an accuracy of 70%. The coarser ASTER-DEM based classification requires additional and more detailed information directly related to soil-forming factors to extract geomorphological parameters. The importance of using LiDAR-DEM classification was particularly evident when classifying landforms that have narrow spatial extent such as embankments and channel banks or when determining the general accuracy of landform boundaries such as crests and flat lands. However, this LiDAR-DEM classification has shown that there are categories of landforms that received a large proportion of the misclassifications such as terraced land and steep embankments in other parts of the study area due to the increased distance from the major rivers and the complex nature of these landforms. In contrast, the results of the ASTER-DEM based classification have shown that the ASTER-DEM cannot deal with small-scale spatial variation of soil and landforms due to the increasing human impacts on landscapes in urban areas. The application of the approach used to extract terrain parameters from the LiDAR-DEM and their use in classification of landforms has shown that it can support soil surveys that require a lot of time and resources for traditional soil mapping.
title: The Role of Telomeric DNA Damage Response RNAs in Alternative Lengthening of Telomeres
Creators: name: Jones-Weinert, Corey Winston
Publisher: name: The Open University
Year: 2022

description: The Alternative Lengthening of Telomeres (ALT) pathway, active in 10-15% of cancers, is characterized by homologous recombination (HR)-dependent telomere lengthening. Telomeres consist of hexameric TTAGGG repeats, which makes them difficult to replicate, and are prone to DNA replication stress. ALT cells display elevated basal levels of replication stress at their telomeres, and this damage has been intimately linked to the ALT phenotype. We recently discovered that non-coding RNAs transcribed de novo at sites of damage, including at telomeres, support local DNA damage signaling and repair. Inhibition of telomeric non-coding RNAs (tncRNAs) with antisense oligonucleotides (ASOs) leads to a reduction in DNA damage responses at uncapped telomeres in cultured cells, as well as in vivo. To further investigate the role of tncRNAs, we quantify their levels in ALT cells and find them to be more highly expressed than in non-ALT cells. We then inhibit tncRNA function with ASOs to further probe their role in ALT cells. Interestingly, inhibition of C- rich tncRNAs, transcribed from the TTAGGG repeats, with antiteloC ASOs induces apoptosis and reduces cell number in ALT-positive cells, but does not affect telomerase- positive or mortal cells. AntiteloC ASOs also induce an S-phase accumulation and inhibition of DNA replication in ALT cells, and non-cycling ALT-positive cells display no sensitivity to antiteloC ASOs, suggesting a prominent role for tncRNAs in overcoming endogenous ALT replication stress. Hydroxyurea treatment, which induces replication stress at common fragile sites such as telomeres, induces tncRNA transcription as well as enhanced sensitivity to antiteloC ASOs both in ALT-positive and ALT-negative cells.

 Taken together, these results suggest that tncRNA transcription is induced upon telomeric replication stress, that teloC species are important in the replication stress response, and that ALT cells are sensitive to antiteloC ASOs due to their high levels of endogenous replication stress.
title: Detrimental and Protective Action of Microglial Extracellular Vesicles on Myelin Lesions: Astrocyte Involvement in Remyelination Failure
Creators: name: Lombardi, Marta
Publisher: name: The Open University
Year: 2020

description: Microglia (MG) are the immune cells of the brain. They have an enormous plasticity in response to brain injury, acquiring different activated phenotypes depending on the stimuli they receive. During multiple sclerosis, MG participate to myelin injury and repair by influencing the function of oligodendrocyte precursor cells (OPCs), the brain cells that differentiate into myelin-forming cells. However, the mode(s) of action of MG in promoting or inhibiting brain repair is still largely unknown. Here, we explored the action of Extracellular Vesicles (EVs) produced in vitro by either pro-inflammatory or pro-regenerative MG on OPCs at myelin lesion induced by lysolecithin injection in the mouse corpus callosum. Immunolabelling for myelin proteins and electron microscopy showed that EVs released by pro-inflammatory MG (i-EVs) impaired remyelination, whereas EVs produced by MG co-cultured with immunosuppressive mesenchymal stem cells (MSC-EVs) promoted OPC recruitment and differentiation at the lesion site. The molecular mechanisms underlying the detrimental/beneficial action of MG EVs were dissected using primary OPC cultures, a powerful system with easy access for EVs. i-EVs promoted OPC differentiation in monoculture, while they caused a clear block of OPC maturation when OPCs were co-cultured with astrocytes, implicating these cells in remyelination failure. Moreover, biochemical fractionation of EV components revealed that astrocyte may be converted in oligotoxic cells by i-EV cargo whereas the lipid components of EVs promoted OPC maturation and migration as indicated by immunohistochemical and qPCR analyses. While the lipid species that enhance OPC maturation remains undefined, we demonstrated a central role for EV-associated S1P in stimulating OPC migration, a fundamental process in remyelination. Collectively, these results uncover a role for microglial EVs as key players in myelin repair, given their ability to influence OPC and astrocyte functions at myelin lesion, and support the study of EV content and function for developing novel approaches for remyelination.
title: Performing Miracles
title: The real magic behind the performance
titleType: Subtitle
Creators: name: Issitt, James
Publisher: name: Lancaster University
Year: 2020

description: Whilst the study of magic, for many years, has examined the mechanics of legerdemain there remains the need for a reflective analytical and pedagogical framework that can be utilised for the exposition and development of the close-up magician’s practice. As a premise, if there are two magicians, Magician A has the best sleight of hand in the world but lacking in performance skills; and Magician B can competently execute ten tricks but has excellent performance – to the layperson, who is the better magician? This text synthesises the theories of magic and performance, in order to create a new analytical tool for the improvement of the skills of the close-up magician. It takes Kowzan’s (1968) 13 Point System as its basis to formulate a new analytical tool. The Issitt 12-point System can be used to analyse a performance of close-up magic and assist in the teaching of performance skills. It offers that the close-up magician’s set comprises three discrete areas: Technical Ability, Performance and Audience Relationship. It suggests that a close-up magician’s practice can be enhanced when all the elements within the new System are considered. The Issitt 12-point System has been tested on the writer’s own practice, that of an apprentice magician, and an expert in the field of close-up magic, Fay Presto. Practitioners in other forms of magic, other performance fields and beyond may consider the new System as a model which can be adapted within their own disciplines.
Study 2 Vaccine Side Effects Explanation & Vaccine Hesitancy Study
Creators: name: Vi Tran
name: Savelli, Sonia
name: Qin, Chao
name: Burgeno, Jessica Noel
name: Agrawal, Nidhi
name: Han, Jee Hoon
name: Joslyn, Susan
Publisher: name: OSF
Year: 2021

description: Two COVID-19 vaccines that have been shown to be about 95% effective are now available. However, surveys have shown that many people are reluctant to get vaccinated (30% in May 2020 study conducted by Reiter, Pennell, & Katz, 2020). Recent research suggests that there are several reasons for COVID-19 vaccine hesitancy. Several of these have to do with specific misunderstandings, including:
1) How the vaccine works
2) The potential side effects of the vaccine
3) Sufficiency of testing
4) What 95% effectiveness means

Previous research suggests that simple explanations of complex issues such as climate change can increase understanding if they are designed to target known misunderstandings. These same explanations were shown to change peoples’ attitudes toward the efficacy of strategies to combat climate change. If the same principles operate in the context of COVID19, carefully designed explanations may dispel misunderstandings as well as encourage more people to get vaccinated.

This study provides an explanation that addresses a misunderstanding concerning the potential side effects of the COVID-19 vaccine. These side effects explanations are focused on people’s mental models or understanding of these side effects. We focus here on issues related to of the vaccine itself, in particular, mRNA vaccines, rather than the effects of COVID (some do not believe the disease is sufficiently dangerous to take any risks to protect against it). We do not address conspiracy theories.
Incremental Data Flow Analysis Algorithms
Creators: name: Paull, Marvin C.
name: Ryder, Barbara G.
Publisher: name: Rutgers University
Year: 1986

description: ACINCF and ACINCB are two incremental update algorithms for global data flow analysis which are based on our linear equations models of Allen/Cocke interval analysis. We have studied their performance on a robust structured programming language L. Given a set of localized program changes in a program in L, we can identify a priori the nodes in its flow graph whose corresponding data flow equations may be affected by the changes. We can characterize these affected nodes by their corresponding program structures and their relation to the original change sites, and do so without actually performing the incremental update algorithm. Our results can be refined to characterize the reduced equations affected when the structured loop exit mechanisms are used singly or together, thereby relating the richness of programming language usage to the ease of incremental updating.
The Importance of the Mentor-Mentee Relationship in Women's Desistance From Destructive Behaviors
Creators: name: Garcia, Janet
Publisher: name: Sage
Year: 2015
Subjects: Reentry
Prisoners--Deinstitutionalization
Reintegration
Desistance
Women
Mentoring

description: According to the literature on desistance, the process of reentering society after imprisonment is distinct from the process of desistance as the former is a broader, institutional process that may influence the latter. Scholars have also acknowledged gendered differences in both reentry and desistance processes. Among the array of players in the lives of formerly incarcerated individuals, mentors have become an increasingly popular form of social support in postincarceration programs—particularly for women in reentry. Given the increasing interest in mentoring programs, this study uses semistructured interviews with mentors (n = 10) and clients (n = 11) in a women’s postincarceration mentoring program to assess the role of mentors in the reentry process and the desistance process. It was found that mentors aid in these processes by serving as facilitators of change for women who are open to such change and by facilitating in constructive behavioral adjustments.
Next-to-Leading Order QCD Corrections to Higgs Boson Production and Mixed QCD-Electroweak Corrections to Z Boson Production at High Transverse Momentum
Creators: name: Kudashkin, Kirill
Publisher: name: Karlsruhe
Year: 2020

description: In this thesis we study two processes: the Higgs boson production when the Higgs transverse momentum larger than the top-quark mass $p_{H,T}\gg m_t$ and the Z boson production at high transverse momentum. The key point of our study is the evaluation of master integrals. Both processes share a similar signature at the high transverse momentum: a hierarchy of scales. This signature is exploited to construct asymptotic expansions of master integrals which allows us to simplify their evaluation. Master integrals are then evaluated using differential equations. The analytical results are expressed in terms of Goncharov polylogarithms. In the case of the Higgs boson production, the evaluation of relevant master integrals allows us to compute two-loop amplitudes for partonic processes $gg\to Hg,\, q\bar{q}\to Hg$ and $qg\to Hg$. These two-loop amplitudes are the long-missing part of next-to-leading order QCD corrections to the Higgs+jet production at high-$p_{H,T}$. The evaluation of next-to-leading order QCD corrections increases the exiting leading-order results by almost a factor of two. This result removes one of the largest theoretical uncertainties in the description of the Higgs+jet production at large-$p_{H,T}$.
Reading for Recovery (R4R): Bibliotherapy for addictions
Creators: name: Ward, Judit Hajnal
name: Bejarano, William
name: Allred, Nicholas
Publisher: name: Rutgers University
Year: 2016
Subjects: Bibliotherapy
Recovery
Treatment modalities
Guided reading
Public libraries

description: The Rutgers Center of Alcohol Studies received a Carnegie-Whitney grant from the American Library Association to build a tool with the purpose of facilitating library resources for creative and informal bibliotherapy. This paper complements the authors’ presentation and workshop at the 2016 conference, where they experimented with a novel interactive format of sharing knowledge to inspire substance abuse librarians to promote bibliotherapy as a potential treatment modality. The two-year project has made a lot of progress to date, such as formulating selection criteria, determining target audiences and choosing the appropriate platforms, designing a vetting process, and compiling a preliminary bibliography. The paper also summarizes a mock bibliotherapy session drawing upon evidence-based practices as the second part of the presentation. Participants read a short text and were encouraged to analyze it based on prefabricated questions and talking points similar to a book club discussion. The authors have benefited tremendously from the conference by building on the collective expertise of the SALIS members.
Mobile phones in Africa: opportunities and challenges for academic librarians
Creators: name: Palumbo, Laura Bolton
Publisher: name: Emerald Insight
Year: 2014
Subjects: Information literacy
Mobile phones
Text messaging
Academic Libraries
Technology
Africa

description: Lack of Internet access and availability of computers in Africa has hindered learning and teaching there. However, the growing prevalence of mobile phones in Africa and elsewhere has created a way for information to be quickly and easily disseminated in areas where access to the Internet and computers are limited. Mobile phones in Africa are currently being used to share information relating to agriculture, as well as other critical topics such as health and finance. This paper will examine these current uses, investigate the current and future use of mobile phones by academic libraries and in education in Africa, and discuss how mobile phones might be leveraged to further education and information dissemination through academic libraries.
A 2-D compressible Navier-Stokes algorithm using an adaptive unstructured grid
Creators: name: Lau, Hin-Fan
name: Knight, Doyle
Publisher: name: Rutgers University
Year: 1994

description: The results of a two-dimensional, compressible, Navier-Stokes solver using an unstructured grid with adaptive remeshing are presented in this paper. Roe’s flux-difference splitting method and Gauss’s Theorem were used correspondingly to represent the inviscid and viscous terms of the Navier-Stokes equation. Temporal integration is performed with a modified Runge-Kutta method. Mesh adaptation is accomplished through five simple error indicators. They are the undivided difference of density, velocity and energy, and the Laplacian of velocity and temperature. After the adaptive process, a global remeshing of the domain was performed using an efficient mesh generator. Two problems were analyzed by the adaptive algorithm. The first was a supersonic flat plate boundary layer at a free stream Mach number M, = 2.0 and Reynolds number (based on the plate length) = 6.5 x lo4. The results were compared with the theoretical Blasius solution. The second case was viscous flow past a NACA 0012 airfoil at zero angle of attack. The free stream Mach number M, = 0.2 and the Reynolds number (based on the airfoil chord) Re, = lo4. The numerical solutions was compared to computational results obtained by the Beam-Warming scheme. Good agreement was observed for both the boundary layer and airfoil computations.
AIR - A Framework for Exploiting Redundancies in Service-Based Applications
Creators: name: Kremer, Ulrich
name: Liu, Liu
Publisher: name: Rutgers University
Year: 2015

description: Redundancy is a fundamental property of most complex systems that makes them more resilient and productive. Instead of relying on a single solution to a problem, multiple solutions are feasible, each solution with its specific resource requirements and cost/quality tradeoffs. This paper targets service-based applications that consist of webs of collaborating services, where productivity, resilience, and energy consumption are crucial. Examples of such applications include mission software for autonomous robots (drones) and service-based smart phone applications. This paper discusses a new framework that allows the specification and optimization of redundancy along three orthogonal redundancy dimensions, namely Approximation, Implementation, and Replication (AIR). The RSDG (Redundant Services Dependence Graph) is a directed, dual-weighted graph with nodes representing redundant services and their quality levels, and edges representing service dependencies. For a given application, the mission value (productivity) of a service node reflects its importance for producing the desired overall application outcome, while the energy value represents its energy consumption, which is not application dependent. Given some application constraints, an optimal solution to an RSDG service selection problem is a set of nodes and edges that maximizes the total mission value while minimizing energy consumption. The optimal selection problem is shown to be NP-complete. AIR’s compiler maps instances of RSDG service selection problems into two dependent 0-1 integer programming problem instances. Experimental results are reported for a servicebased application that specifies sensing, actuation, and communication activities of an autonomous underwater vehicle (AUV). The results were based on an AUV deployment in the Atlantic Ocean. They show that the AIR framework is expressive and efficient. The overall application productivity and resilience was greatly improved by dynamically recomputing the optimal solution to reflect changes in energy reserves, mission goals, or to deal with service failures. In an application’s design stage, AIR can be used to assess and adjust service redundancies for productivity and resilience under anticipated usage patterns and failure conditions. To the best of our knowledge, AIR is the first system that represents and optimizes all three dimensions of redundancy within a single framework.
The rule of law in multidistrict litigation
Creators: name: Noll, David L.
Publisher: name: Rutgers University
Year: 2019
Subjects: Multidistrict litigation
MDL
Civil procedure
Ad hoc procedure
Administrative Procedure Act
Judicial administration
Deepwater Horizon
Opioids
Vioxx
Litigation
1407
Administrative Law

description: From the Deepwater Horizon disaster to the opioid crisis, multidistrict litigation—or simply MDL—has become the preeminent forum for devising solutions to the most difficult problems in the federal courts. MDL works by refusing to follow a regular procedural playbook. Its solutions are case-specific, evolving, and ad hoc. This very flexibility, however, provokes charges that MDL violates basic requirements of the rule of law. At the heart of these charges is the assumption that MDL is simply a larger version of the litigation that takes place every day in federal district courts. But MDL is not just different in scale than ordinary litigation; it is different in kind. In structure and operation, MDL parallels programs like Social Security where an administrative agency continuously develops new procedures to handle a high volume of changing claims. Accordingly, MDL is appropriately judged against the “administrative” rule of law that emerged in the decades after World War II, and which underpins the legitimacy of the modern administrative state. When one views MDL as an administrative program instead of a larger version of ordinary civil litigation, the real threats to the legitimacy of its model of aggregate litigation come into focus. The problem is not that MDL is ad hoc. Rather, it is that MDL lacks guarantees of transparency, public participation, and judicial review that administrative agencies have operated under since the middle of the twentieth century. The history of the administrative state suggests that MDL’s continued success as a forum for resolving staggeringly complex problems depends on how it addresses these governance deficits.