cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New substituted 2-aminomethyl-2-oxo-2λ5-perhydro-[1,3,2]oxazaphospholo [3,4-a]pyridine: Design, synthesis and antimicrobial activity
Creators: name: Madhava Golla
name: Subba Rao Devineni
name: Syed, Rasheed
name: Bhanu Kiran Rayalacheru
name: Rajasekhar Maram
name: Chamarthi Naga Raju
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: The synthesis of a new series of P-heterocyclic compounds, substituted 2-aminomethyl-2-oxo-2λ5-perhydro-[1,3,2]oxazaphospholo[3,4-a]pyridine derivatives 8(a-j), was accomplished. A key intermediate, 2-(chloromethyl)-2-oxo-2λ5-perhydro-[1,3,2]oxazaphospholo[3,4-a]pyridine (6) was primarily synthesized by the condensation of (±)-2-piperidinemethanol (4) and chloromethylphosphonic dichloride (5); subsequently, it was treated with various heterocyclic amines/benzylamines/aminoacid esters, 7(a-j) to obtain the desired products. The structures of the newly synthesized compounds were elucidated by 1H, 13C, and 31P NMR spectroscopy, mass spectra and elemental analyses. The biological potency of title products was investigated by screening in vitro antimicrobial activity. The bio-screening data revealed that most of the synthesized derivatives showed potent growth of inhibition against fungi while compared with bacteria. Particularly, compounds 8c and 8i against bacterial strains, and 8a and 8f against fungi exhibited promising activity.
Atom lithography using a Bose Einstein Condensate and an Atom Laser beam
Creators: name: Richberg, Roham
Publisher: name: The Australian National University
Year: 2021

description: Atom lithography is a technique where the gradient forces applied by laser fields on a beam of atoms are used to direct the atoms into nanostructures deposited on a plane surface. It has been the topic of considerable study in the scope of atom optics over the last two decades as it can provide a scheme of writing nanometer structures directly onto a substrate in parallel process. The main application in the development of nano-lithography could be the race for an increased density of three-dimensional transistors in the computer chips. One of the certain objectives in this technology is to minimize the size of fabricated structures, which is limited by the oven sources of atoms. This thesis studies the possibility of exploiting a Bose Einstein Condensate of rubidium-85 (85Rb) and rubidium-87 (87Rb) as a source of ultra-cold atoms instead of traditional oven sources of neutral atoms in atom lithography and nano fabrication, which is a new emerging area and is deemed to break the mentioned limitation providing one with superior structure linewidths. For this purpose, two major regimes are considered. Firstly, by dropping a condensed atom cloud into an optical focusing potential, we seek the optimal ways of achieving the smallest structures possible. Secondly, we investigate the focusing dynamics of an atom laser beam as a highly bright, coherent and a monochromatic matter-wave. The focusing potential utilized in both cases can be produced in any arbitrary geometries such that, optical lattices as well as harmonic potentials are chosen as our preferred focusing fields. In both stated configurations, the inter-atomic interactions within the BEC and atom laser play a key role in estimating the resultant focal spot sizes and peak densities. While this significant factor is taken into account via our proposed theoretical models, we extract and implement the optical properties of potential fields in the process of focusing to obtain reasonably the highest achievable structure resolutions. Furthermore, by tuning the atomic interaction strength within the condensate and atom laser beam over a large flexible range via a Feshbach resonance, we explore the interaction impact on a focused profile. The tunability of interactions between atoms can be advantageous and deleterious for the structure flux, which is discussed by examples. More specifically, the influence of the three-body recombination losses on focused structures are studied through our numerical and analytical approaches. This especially becomes remarkable in high density regimes. Overall, it is shown that nanofabrication using a Bose Einstein Condensate and an atom laser offers a dramatic improvement in resolution of the write beam up to 8 nm as it considerably reduces several detrimental aberrations such as the longitudinal and transverse velocity distributions and consequently the beam divergence, which even results in a self-focusing (converging) beam.
New Python based Architecture for the Keck Observatory Archive
Creators: name: Moseley, Rosemary
name: Berriman, Bruce
name: Gelino, Christopher
name: Good, John
name: Oluyide, Toba
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Astronomy
subject: Data Management
subject: Data Archiving
subject: User Interface
subject: Data Visualization

description: We describe the development of the Keck Observatory Archive (KOA) Data Discovery Service, a web-based dashboard that returns metadata for wide-area queries of the entire KOA archive within seconds. Currently in beta, this dashboard will support exploration, visualization, and data access across multiple instruments. This effort is underpinned by open-source VO compliant query infrastructure, and will offer services that can be hosted on web pages or in Jupyter notebooks. The effort also informs the design of a new modern landing page that meets expectations of accessibility and ease of use.

 

The new query infrastructure is based on nexsciTAP, a component-based, DBMS-agnostic Python implementation of the IVOA Table Access Protocol, developed at NExScI and integrated into the NASA Exoplanet Archive and the NEID archive, and into the PyKOA Python client. This infrastructure incorporates R-tree spatial indexing, built as memory-mapped files as part of Montage, a software toolkit used to create composite astronomical images. R-trees are used most often in geospatial analysis, here they enable searches of the entire KOA archive, an eclectic collection of 100 million records of imaging and spectroscopic data, in 2 seconds, and speeds up spatial searches by x20. The front end is built on the open-source Plotly-Dash framework, which allows users to build an interactive user interface based on a single python file.
Effects of Rearview Cameras and Rear Parking Sensors on Police-Reported Backing Crashes
Creators: name: Cicchino, Jessica B.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: To examine the effectiveness of rearview cameras, rear parking sensors, and both systems combined in preventing police-reported backing crashes. Methods: Negative binomial regression was used to compare rates of police-reported backing crash involvements per insured vehicle year in 22 U.S. states during 2009–2014 between passenger vehicle models with backing technologies and the same vehicle models where the optional systems were not purchased, controlling for other factors affecting crash risk. Rearview cameras were examined from four automakers, rear parking sensors from two automakers, and both systems combined from a single automaker. Results: Rearview cameras reduced backing crash involvement rates by 17%. Reductions were larger for drivers 70 and older (36%) than for drivers younger than 70 (16%); however, estimates for older and younger drivers did not differ significantly from one another. The Buick Lucerne's rear parking sensor system reduced backing crash involvement rates significantly by 34%, but the reduction for Mercedes-Benz vehicles fit with a sensor system was small and not statistically significant. When averaged between the two automakers, effects were significantly larger for drivers 70 and older (38% reduction) than for drivers younger than 70 (1% increase); effects were significant for older, but not younger, drivers. Backing crash involvement rates were 13% lower among Mercedes-Benz vehicles with a rearview camera and parking sensors than among vehicles without, but this finding was not significant. Discussion: Rearview cameras are effective in preventing police-reported backing crashes. Effects of rear parking sensors are less straightforward; it is unclear if the Buick Lucerne system's benefits are due to the older age of its drivers, characteristics of the vehicle or system, or a combination. Systems may be especially beneficial to older drivers who might have limitations that make backing challenging. Although effect estimates did not differ significantly between older and younger drivers for both system types, the magnitude of the differences were large and the pattern of results was consistent across six of the seven systems examined. When rear visibility systems become required equipment on new passenger vehicles in 2018, rearview cameras can be expected to prevent 1 in 6 backing crashes reported to police that involve equipped vehicles.
Carbonate Accumulation in the Bark of Terminalia bellirica: A New Habitat for the Oxalate-Carbonate Pathway
Creators: name: Hervé, Vincent
name: Clerc, Martin
name: Cailleau, Guillaume
name: Bueche, Matthieu
name: Junier, Thomas
name: Verrecchia, Eric
name: Junier, Pilar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Computational Biology

description: Oxalate oxidation and carbonate precipitation associated with the oxalogenic tree Terminalia bellirica were investigated. Calcium oxalate crystals, oxalotrophic bacteria (dominated by genera Methylobacterium and Burkholderia), and carbonate accumulation (82% dry weight), were detected in the bark. In contrast, only a slight accumulation of carbonate was observed in soil (1.5%). The combined geochemical and microbiological analyses suggest that bark of an Indian living tree represents a novel habitat for the accumulation of carbonate associated with bacterial oxalate oxidation. The importance of these types of habitats needs to be quantified when considering the biogeochemical cycling of carbon and calcium in tropical ecosystems.
The effects of pH on the partitioning of aromatic acids in a polyethylene glycol/dextran aqueous biphasic system
Creators: name: Moody, Melanie L.
name: Huddleston, Jonathan G.
name: Berton, Paula
name: Zhang, Jianhua
name: Rogers, Robin D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Distribution ratios of acidic, neutral, and basic compounds were determined in polyethylene glycol (PEG)-6000/Dextran-75000 aqueous biphasic systems (ABSs) at incremental pH values. The nature of the solute species present at each pH was identified using speciation diagrams, and it was determined that the distribution ratios were related to their charge, with maximum distribution to the upper PEG-rich phase when the neutral species were dominant. The results suggest that this ABS is tunable with simple modifications of pH leading to increasing selectivity for specific target solutes.
Three decades (1874?1905) of moneylending in rural Japan
Creators: name: Izumida, Yoichi
name: Yukiteru, Ohguri
Publisher: name: Universit� degli studi di Bergamo
Year: 2017

description: This study aims to analyze the lending activities of one family for a 32-year period (1874?1905) based on their books and notes in a village in Meiji Japan. By using long-term microdata from the supply side, we show the features, changes, and outcomes of informal moneylending. In particular, we elucidate the impact of financial improvement on assets distribution, one of missing points in a discussion of microfinance. We conclude that increasing access to modern finance does not always lead to improvement of the economic welfare of the poor.
title: 01_1561
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Carbonate accumulation in the bark of Terminalia bellirica: A new habitat for the oxalate-carbonate pathway
Creators: name: Hervé, Vincent
name: Clerc, Martin
name: Cailleau, Guillaume
name: Bueche, Matthieu
name: Junier, Thomas
name: Verrecchia, Eric
name: Junier, Pilar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Computational Biology

description: Oxalate oxidation and carbonate precipitation were investigated associated to the oxalogenic tree Terminalia bellirica. Calcium oxalate crystals, oxalotrophic bacteria (dominated by genera Methylobacterium and Burkholderia), and carbonate accumulation (82% dry weight), were detected in the bark. In contrast, only a slight accumulation of carbonate was observed in soil (1.5%). The combined geochemical and microbiological analyses suggest that bark of an Indian living tree represents a novel habitat for the accumulation of carbonate associated with bacterial oxalate oxidation. The importance of these types of habitats needs to be quantified when considering the biogeochemical cycling of carbon and calcium in tropical ecosystems.
Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9
Creators: name: Rastogi, Bhawna
name: Kumar, Amit
name: Raut, Satish K.
name: Panda, Naresh K.
name: Rattan, Vidya
name: Joshi, Nainesh
name: Khullar, Madhu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: microRNAs are the post-transcriptional regulators implicated in the initiation and progression of various cancer types, including oral squamous cell carcinoma (OSCC). Here, we investigated the role of miR-377 in OSCC tumorigenesis. miR-377 expression was reduced in OSCC samples and cell line (UPCI-SCC-116), and was associated with patient survival. In vitro restoration of miR-377 repressed cell growth, induced apoptosis, and reduced cell migration. We identified HDAC9 as a target of miR-377 and found miR-377 to regulate HDAC9 and its pro-apoptotic target, NR4A1/Nur77. Our findings show that miR-377 targets HDAC9 pathway in OSCC, suggesting that miR-377–HDAC9 axis may provide a novel therapeutic target for OSCC therapy.
High production of xanthan gum by a glycerol-tolerant strain Xanthomonas campestris WXLB-006
Creators: name: Wang, Zichao
name: Wu, Jianrong
name: Gao, Min-Jie
name: Zhu, Li
name: Zhan, Xiao-Bei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: The superior properties of xanthan gum make it an industrial aginomoto used in many industries, especially in oil recovery. In the present work, xanthan production from glycerol by a mutant strain Xanthomonas campestris WXLB-006 reached as high as 17.8 g/L in flask culture. With the adoption of pH control, varied aeration and agitation, and varied glycerol feeding strategy, xanthan production reached 33.9 g/L in a 7-L fermenter and fermentation time decreased to 60 hr. Instead of difficultly and costly purifying glycerol, this research provides a very good case for glycerol utilization. At the same time, this is the first report on a high glycerol-tolerant strain for microbial polysaccharide production and 33.9 g/L is the highest production of xanthan gum produced from glycerol so far.
Flooding in ephemeral streams: incorporating transmission losses
Creators: name: A. Pacheco-Guerrero
name: D. C. Goodrich
name: J. González-Trinidad
name: H. E. Júnez-Ferreira
name: C. F. Bautista-Capetillo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Streamflow in semi-arid lands commonly occurs in the form of flash floods in dry-bed ephemeral streams. The goal of this research was to couple hydrological and 2D hydraulic model treatments of channel transmission losses, in order to show the impact of not taking transmission losses on flood hazard mapping into consideration. For hydraulic modeling the reach that is located between flumes 2 and 1 in the Walnut Gulch Experimental Watershed was tested. Two hydraulics models were set up, the first does not incorporate channel transmission and the second was developed to take into account several hydrographs with transmission losses as boundary conditions. The error in volume and peak runoff rate between the observed and simulated data ranges was in the order of –4.5–34.4% for runoff volume and –16.4–9.6% for peak runoff rate. The computation output interval time in the hydraulic model was 60 s and the duration of flood inundation was 6.67 h. There are important differences in depth between the two flood maps, with 0.68 maximum and 0 m minimum. The importance of using models with the dynamic treatment of transmission losses is the ability to provide an improved estimate for flood hazard mapping.
Biological and molecular characterization of Zucchini yellow mosaic virus isolates infecting melon in Xinjiang, China
Creators: name: Wang, Dong
name: Li, Guan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Zucchini yellow mosaic virus (ZYMV) causes one of the most destructive diseases of cucurbits worldwide. Although the virus has been present in China for more than 25 years, there is little information about biological and molecular traits of ZYMV isolates from China. This study aimed to characterize 26 ZYMV isolates from Xinjiang, China based on pathotypes, molecular variability and host range. Phylogenetic analysis of the complete sequences of the coat protein gene revealed three distinct groups (A, B and C), with four subgroups in A (I–IV). All isolates from Xinjiang were placed in group C and subgroups A–I and A–II. To test for differences in host range among different phylogenetic groups from Xinjiang, 13 isolates were mechanically inoculated onto 14 plant species in five families and their pathotypes were also identified based on the reaction of a resistant melon accession PI414723. Overall, the results showed that there were no correlations of host responses to inoculation with ZYMV isolates from different phylogenetic groups. However, on Cucurbita pepo, differences in host responses to inoculation with the ZYMV isolates from different phylogenetic groups were observed. Although the host range of the 13 isolates tested was similar, their biological properties on different hosts were slightly different from the ZYMV isolates characterized in other countries. The results of the pathotype test showed that the 13 ZYMV isolates were classified as pathotype 0. The information obtained is important in breeding for resistant varieties.
ADAMTSL4 assessment in ectopia lentis reveals a recurrent founder mutation in Polynesians
Creators: name: Bysterveldt, Katherine A. Van
name: Taie, Rasha Al
name: Ikink, Will
name: Oliver, Verity F.
name: Vincent, Andrea L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Background: To clinically characterize a cohort of patients with ectopia lentis (EL), or Marfanoid features in whom a definite genetic diagnosis of Marfan syndrome (MFS) had been excluded (atypical MFS), and to evaluate the contribution of mutations in ADAMTSL4 (OMIM * 610113), and P3H2 (LEPREL1; OMIM * 610341) to disease in this population. Materials and Methods: Subjects underwent comprehensive ophthalmic examination, including keratometry. Mutational analysis of ADAMTSL4 and P3H2 was undertaken using PCR, high resolution melting analysis, and sequencing. The frequency of c.2237G>A; p.(Arg746His) was determined in an unaffected Polynesian cohort. Haplotype analysis used tagged single nucleotide polymorphic markers. Results: Mutational analysis of ADAMTSL4 identified two pathogenic variants in ADAMTSL4 in 11/31 (35%) probands, consistent with the autosomal recessive EL phenotype. A recurrent, rare missense variant in ADAMTSL4, c.2237G>A; p.(Arg746His), was present in 10 probands –(8 homozygotes), predominantly of Polynesian descent, and all shared the same haplotype. p.(Arg746His) affects the Thrombospondin1 (TSP1) domain of the protein and is predicted to be pathogenic. No pathogenic variants in P3H2 were identified. Conclusion: A recurrent pathogenic ADAMTSL4 variant is a major cause of early onset autosomal recessive EL in a Cook Island Māori population and associated with a common haplotype, suggesting a founder effect. Children presenting under the age of 5 years, particularly of Cook Island or New Zealand Māori descent, with isolated ectopia lentis, should in the first instance be tested for this single variant.
Using dual-sex calls improves the playback census method for a nocturnal burrow-nesting seabird, the Manx Shearwater Puffinus puffinus
Creators: name: Perkins, Allan J.
name: Douse, Andy
name: Morgan, Greg
name: Cooper, Amy
name: Bolton, Mark
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Capsule: Playback with dual-sex calls increases the response rate of Manx Shearwaters Puffinus puffinus by 40–60% and reduces its daily variability, which would improve the precision of population estimates. Aims: To test whether playing male and female calls would elicit more responses to playback than male-only calls, reduce daily variability and the length of response rate calibration trials, and give more precise estimates. We also measured response times to playback and assessed the reliability of visual signs of occupancy at burrow entrances. Methods: Responses to four playback call-types (male-only and three variants of dual-sex calls) were compared in repeated trials at two colonies (Ramsey and Rum, UK) during May–June 2014. Results: Dual-sex calls gave higher response rates with lower variance than male-only calls, because females frequently replied to female calls but rarely to male calls. In simulated 3–5-day calibration trials, response rates and correction factors were up to 50% more precise with dual-sex calls. Visual signs of burrow occupancy were unreliable. Conclusion: Playback for Manx Shearwaters should use a 25 seconds recording of male and female calls intermixed, with 10 seconds listening time for delayed responses. Census-specific calibration trials are essential for accurate estimates of daily response rates.
Oncogenic retinoic acid receptor γ knockdown reverses multi-drug resistance of human colorectal cancer via Wnt/β-catenin pathway
Creators: name: Huang, Gui-Li
name: Song, Wei
name: Zhou, Pan
name: Fu, Qi-Rui
name: Lin, Chen-Lu
name: Chen, Qing-Xi
name: Shen, Dong-Yan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Retinoic acid receptor γ (RARγ), a unique member of the nuclear receptor superfamily, plays an important role in the progression of several cancers such as hepatocellular carcinoma, esophageal cancer, and cholangiocarcinoma. However, little is known about the regulatory mechanism of the RARγ expression in colorectal cancer (CRC) progression. In the present study, we found that RARγ was frequently overexpressed in human CRC specimens and CRC cell lines, and it mainly resided in the cytoplasm in CRC specimens. Tissue microarrays showed that RARγ indicated vital clinical significance in CRC. RARγ knockdown neither affected CRC cell proliferation nor blocked the cell cycle of CRC cells. However, RARγ knockdown increased the sensitivity of CRC cells to chemotherapeutics through downregulation of multi-drug resistance 1(MDR1). Further studies suggested that RARγ knockdown resulted in downregulation of MDR1, in parallel with suppression of the Wnt/β-catenin pathway. Moreover, a significantly positive association between RARγ and MDR1 was demonstrated in CRC tissue microarrays. Collectively, these results suggested that overexpression of RARγ contributed to the multidrug chemoresistance of CRC cells, at least in part due to upregulation of MDR1 via activation of the Wnt/β-catenin pathway, indicating that RARγ might serve as a potential therapeutic target for chemoresistant CRC patients.
Urbanization dynamics of Tehran city (1975–2015) using artificial neural networks
Creators: name: Alireza Taravat
name: Masih Rajaei
name: Emadodin, Iraj
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Computational Biology

description: Land-use dynamic is a major challenge for town and country planners especially in developing countries such as Iran. Iran has been under rapid urban expansion and population growth for past three decades which led to lack of resources, environmental deterioration and haphazard landscape development. In this paper, an attempt has been made to map the urbanization dynamics of Tehran in 40 years based on remote sensing imagery and by means of artificial neural networks. The presented scheme could be taken into consideration when planning initiatives aimed at surveying, monitoring, managing and sustainable development of the territory. Moreover, it can serve the experts in the fields of geography, urban studies and planning as a background for number of geographical analyses.
Oncogenic Retinoic Acid Receptor γ Knockdown Reverses Multi-Drug Resistance of Human Colorectal Cancer via Wnt/β-catenin pathway
Creators: name: Huang, Gui-Li
name: Song, Wei
name: Zhou, Pan
name: Fu, Qi-Rui
name: Lin, Chen-Lu
name: Chen, Qing-Xi
name: Shen, Dong-Yan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Retinoic acid receptor γ (RARγ), a unique member of the nuclear receptor superfamily, plays an important role in the progression of several cancers such as hepatocellular carcinoma, esophageal cancer, and cholangiocarcinoma. However, little is known about the regulatory mechanism of the RARγ expression in colorectal cancer (CRC) progression. In the present study, we found that RARγ was frequently overexpressed in human CRC specimens and CRC cell lines, and it mainly resided in the cytoplasm in CRC specimens. Tissue microarrays showed that RARγ indicated vital clinical significance in CRC. RARγ knockdown neither affected CRC cell proliferation nor blocked the cell cycle of CRC cells. However, RARγ knockdown increased the sensitivity to chemotherapeutics through downregulation of multi-drug resistance 1(MDR1). Further studies suggested that RARγ knockdown resulted in downregulation of MDR1, in parallel with suppression of the Wnt/β-catenin pathway. Moreover, a significantly positive association between RARγ and MDR1was demonstrated in CRC tissue microarrays. Collectively, these results suggested that overexpression of RARγ contributed to the multidrug chemoresistance of CRC cells, at least in part due to upregulation of MDR1 via activation of the Wnt/β-catenin pathway, indicating that RARγ might serve as a potential therapeutic target for chemoresistant CRC patients.
High-quality fuel from food waste – investigation of a stepwise process from the perspective of technology development
Creators: name: Yin, Ke
name: Li, Ling
name: Giannis, Apostolos
name: Weerachanchai, Piyarat
name: Ng, Bernard J. H.
name: Wang, Jing-Yuan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: A stepwise process (SP) was developed for sustainable energy production from food waste (FW). The process comprised of hydrothermal treatment followed by oil upgrading. Synthetic food waste was primarily used as feedstock in the hydrothermal reactor under subcritical water conditions. The produced hydrochars were analyzed for calorific value (17.0–33.7 MJ/kg) and elemental composition indicating high-quality fuel comparable to coal. Hydrothermal carbonization (e.g. 180°C) would be efficient for oil recovery (>90%) from FW, as compared to hydrothermal liquefaction (320°C) whereby lipid degradation may take place. The recovered oil was upgraded to biodiesel in a catalytic refinery process. Selected biodiesels, that is, B3 and B4 were characterized for density (872.7 and 895.5 kg/m3), kinematic viscosity (3.115 and 8.243 cSt), flash and pour point (30°C and >126°C), micro carbon (0.03% and 0.04%), sulfur (both <0.0016%), and calorific value (38,917 and 39,584 J/g), suggesting similar quality to commercial biodiesel. Fatty acid methyl ethers content was further analyzed to assess the influence of hydrothermal treatment in biodiesel quality, indicating the limited impacts. Overall, the SP provides a promising alternative for sustainable energy recovery through high-quality biofuel and hydrochar production.
Early adolescent language development following intrathecal chemotherapy for acute lymphoblastic leukaemia
Creators: name: Lewis, Fiona M.
name: Jaycie K. Bohan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Purpose: Central nervous system (CNS) prophylaxis in the treatment of childhood acute lymphoblastic leukaemia (ALL) is routinely achieved through intrathecal chemotherapy (ITC). The presence of high level language deficits in older children who received CNS-directed ITC for ALL in early childhood is yet to be elucidated, with previous research suggesting that high level language deficits may appear later in ALL survivors’ development at an age when these skills typically emerge. Method: A test battery covering foundational language skills and higher-order language skills was administered to five participants (aged 10–15 years) with a history of ITC for ALL. Conversion of each child’s language performance scores to z scores allowed for clinical interpretation of data across the language areas tested. Result: Foundational language skills were, in general, of no clinical concern. Three of the five children presented with clinically impaired language skills in areas including resolving ambiguity, making inferences and composing novel sentences. Performance variation between the participants and within the individual participants was noted. Conclusion: Given the importance of early adolescent language abilities to academic and social development in late primary and secondary schooling, these preliminary findings suggest further research into emerging adolescent language abilities following ITC for ALL is warranted.
Potent immune responses induced by a Salmonella ghost delivery system that expresses the recombinant Stx2eB, FedF, and FedA proteins of the Escherichia coli-producing F18 and Shiga toxin in a murine model and evaluation of its protective effect as a porcine vaccine candidate
Creators: name: Gayeon Won
name: Hwa, Lee John
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: In the pathogenicity of porcine edema disease (ED), which is caused by the Escherichia coli-producing F18 and Shiga toxin, F18+ fimbrial adhesins and Shiga toxin 2e (Stx2e) play pivotal roles in the colonization and enterotoxicity of this pathogen. Objective: To develop a vaccine candidate against ED by combining three selected antigens of F18+ E. coli. Methods: Genetically engineered Salmonella Typhimurium (ST) ghosts that express Stx2eB, FedF, and FedA were individually inserted in a ghost plasmid cassette, and the resultant plasmids were transformed into an attenuated ST (JOL912). The individual expression of Stx2eB, FedF, and FedA in JOL912 was validated by using an immunoblotting assay. Results: Immunization of the ghosts in BALB/c mice led to a significant increase in antigen-specific secretory IgA and serum IgG. Significantly marked elevation of the CD3+CD4+ T cell subpopulation and lymphocyte proliferating activity in the primed splenocytes were also observed. Furthermore, mRNA of IL-4 and IFN-γ were highly upregulated in  in vitro stimulated splenic T cells. Subsequently, the immunized mice showed significant protection efficacy against a lethal dose 50 of a virulent strain, resulting in approximately 85% and 92% survival rates in mice with a single- and double-dose immunization, respectively, compared to only 40% of the non-immunized controls. Conclusion: A mixture of the ghosts expressing these three antigens is a potential vaccine candidate for protection against the porcine edema disease.
Correlations between sleep patterns and cardiovascular diseases in a Chinese middle-aged population
Creators: name: Wang, Chuangshi
name: Hao, Guang
name: Bo, Jian
name: Li, Wei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Epidemiological and animal studies have suggested an association between habitual sleep patterns and cardiovascular (CV) disease, but the results are still controversial. Therefore, the aims of this study are to investigate the relationships between habitual sleep patterns and CV disease based on Prospective Urban Rural Epidemiology (PURE) China study. PURE China study recruited 46 285 participants, aged 35–70, from 12 provinces and 115 communities in China. Habitual sleep patterns and CV disease were self-reported. Multilevel logistic regression was used in our analysis. In this study, 39 515 participants were eligible in our analysis, including 23 345 (59.1%) women and 16 170 (40.9%) men. Sleeping ≥9 h per day was associated with increased odds of CV disease (OR = 1.16, 95% CI: 1.01–1.32, p = 0.033) compared with sleeping 7–8 h per day. Taking daytime naps was also associated with an increased odds of CV disease, and the CV odds increased with increasing napping duration (p for trend < 0.001). For the sleeping < 6 h per day, we only found an association with coronary artery disease (CAD) (OR = 1.58, 95% CI: 1.01–2.48, p = 0.046). Participants with only 7–8 h sleep per night had lowest prevalence of CV disease (OR = 0.77, 95% CI: 0.65–0.90, p = 0.001) compared with other sleep patterns. Napping, long and short duration of habitual sleep may increase the odds of CV disease. Only participants sleeping 7–8 hours at night are recommended in this study, and large longitudinal studies are needed to confirm these results.
Test MM Type B by DHAI (Project) (2021) | Type-B (ID n° 457)
Creators: name: DHAI, Project
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Astronomy
History of astronomy
DISHAS
Astronomical table

description: This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses:
 it is based on several different editions, themselves based on tables from different primary sources.
 A type-B edition can be based on type-A, type-B or type-C editions.
You can find it on the DISHAS project website from this link: https://dishas.obspm.fr/table-edition/457
Geochemical characteristics of mud volcano fluids in the southern margin of the Junggar basin, NW China: implications for fluid origin and mud volcano formation mechanisms
Creators: name: Wan, Zhifeng
name: Wang, Xianqing
name: Lu, Ye
name: Sun, Yuefeng
name: Xia, Bin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Mud volcanoes can provide important information about the underlying strata, hydrocarbon accumulation, and recent neotectonic movements in an area. The fluids erupting from mud volcanoes provide important information about their formation and evolution. The ion concentration and the hydrogen and oxygen isotopes of the fluids that were erupted from the three mud volcano groups, Baiyanggou, Aiqigou, and Dushanzi, and nearby rivers in the southern margin of the Junggar basin, northwestern China, are studied. The concentrations of Na and Cl in mud volcano fluids are clearly elevated, displayed as the Na-Cl type. The δD and δ18O values of the fluids are similar between the Baiyanggou and Dushanzi mud volcanoes, which are mainly from ancient sedimentary pore water. However, the Aiqigou mud volcano is depleted in dissolved Cl and shows lower δ18O values with mixed sources, including deep pore and local meteoric water. Two types of mud volcanoes are proposed in this study. One type is low-energy mud volcanoes with a low volume of fluid of deep origin on the hillcrest, which display as mud pool/pie/hole. The other type is high-energy mud volcanoes having mixed fluid origin in the valley and formed in the shape of a mud cone (dome).
Optimal duration of ultra low frequency-transcutaneous electrical nerve stimulation (ULF-TENS) therapy for muscular relaxation in neuromuscular occlusion: A preliminary clinical study
Creators: name: Esclassan, Rémi
name: Rumerio, Anaïs
name: Monsarrat, Paul
name: Combadazou, Jean Claude
name: Champion, Jean
name: Destruhaut, Florent
name: Ghrenassia, Christophe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Computational Biology

description: Objectives: The primary aim of this work was to determine the duration of ultra-low-frequency transcutaneous electrical nerve stimulation (ULF-TENS) application necessary to achieve sufficient relaxation of the masticatory muscles. A secondary aim was to analyze the influence of stimulation on muscle relaxation in pathological subjects and determine whether ULF-TENS has a noteworthy impact on muscle relaxation. Methods: Sixteen adult subjects with temporomandibular disorders (TMD) and muscle pain and a group of four control subjects were included in this study. ULF-TENS was applied, and muscular activities of the masseter, temporal, and sternocleidomastoid muscles (SCM) were recorded for 60 min. Results: Significant relaxation was achieved in the TMD group from 20, 40, and 60 min for the temporal, masseter, and SCM muscles (p p Discussion: Taken together, the results suggest that an ideal ULF-TENS application would last 40 min to obtain sufficient muscle relaxation both in patients with masticatory system disorders and healthy subjects, a time constraint that is consistent with everyday clinical practice.
High-grade calcareous metasediments from the Sawtooth Metamorphic Complex, Idaho, USA: evidence for passive margin strata and polymetamorphism within the Idaho batholith
Creators: name: Fukai, Isis
name: Dutrow, Barbara L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry

description: The Sawtooth Metamorphic Complex (SMC) of central Idaho contains exposures of metasupracrustal rocks, in a crucial location between the Archaean Wyoming craton to the east and the adjacent Mesozoic terranes to the west, that provide constraints on Precambrian crustal evolution in the northwestern United States. Mineral textures, whole-rock geochemistry, and thermobarometry of calc-silicate gneisses record multiple stages of crustal evolution, including protolith deposition, burial and multiple metamorphic and deformational overprints. Whole-rock signatures are consistent with derivation from post-Archaean, continental sources that have undergone sedimentary maturation and recycling typical of clastic sedimentation in passive-margin environments and with a metamorphosed sequence of calcareous sandstones and marls, containing varying proportions of clay and quartzo-feldspathic detritus. The sandstone-to-marl continuum may reflect a shallow-to-deep water transition in the depositional environment of the calc-silicate protoliths. Two metamorphic events and three deformational events are preserved. The assemblage clinopyroxene + quartz + plagioclase + K-feldspar + rutile represents peak metamorphic conditions (M1), estimated at 750–775°C with relatively oxidized metamorphic fluids, during development of D1a foliation. Deformation twinning in clinopyroxene records a widespread, high strain D1b event at high temperature. A second static thermal event (M2), associated with randomly oriented amphiboles overprinting M1 and D1b features, records conditions of ~550–725°C and H2O-rich fluids. Late-stage, brittle–ductile D2 deformation is characterized by mylonitic lenses of quartz, fractures within M1 clinopyroxenes that crosscut D1b deformation twins, and localized fracturing of M2 amphiboles. Geochemical and mineral chemical signatures of SMC calc-silicates preserve fingerprints of the original protolith through burial to mid-crustal conditions and high-grade metamorphism and suggest crustal thickening to about 20 km. The SMC may reflect rocks at depth beneath the Idaho batholith. These data, indicative of newly recognized post-Archaean terrain with passive-margin, continental sediments suggest that a continuous Cordilleran passive margin sequence may have extended along the western edge of Laurentia.