cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Confronting GRB prompt emission with a model for subphotospheric dissipation
Creators: name: Ahlgren, Björn
name: Larsson, Josefin
name: Nymark, Tanja
name: Ryde, Felix
name: Pe'er, Asaf
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The origin of the prompt emission in gamma-ray bursts (GRBs) is still an unsolved problem and several different mechanisms have been suggested. Here we fit Fermi GRB data with a photospheric emission model which includes dissipation of the jet kinetic energy below the photosphere. The resulting spectra are dominated by Comptonization and contain no significant contribution from synchrotron radiation. In order to fit to the data we span a physically motivated part of the model's parameter space and create DREAM ($\textit{Dissipation with Radiative Emission as A table Model}$), a table model for ${\scriptsize XSPEC}$. We show that this model can describe different kinds of GRB spectra, including GRB 090618, representing a typical Band function spectrum, and GRB 100724B, illustrating a double peaked spectrum, previously fitted with a Band+blackbody model, suggesting they originate from a similar scenario. We suggest that the main difference between these two types of bursts is the optical depth at the dissipation site.
description: 6 pages, 2 figures, accepted to MNRAS as a Letter
Viola calchaquiensis W. Becker 1926
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola calchaquiensis

description: Viola calchaquiensis W. Becker (1926a: 226)
 Type (lectotype, designated here):— ARGENTINA. Tucumán: Cumbres Calchaquíes, 4500 m, 7 January 1908, L. Castillón 269 ( ex herbario Lillo nº 8262 ) (LIL 001870 [digital image!]; isolectotypes, B [destroyed], BAF [missing]).
 Protologue citation:— “Argentina borealis: Prov. Tucumán, Cumbres Calchaquies, 4500 m, 7. I. 1908 leg M. Lillo sub no. 8262. Typus in herb. W. Bckr. et Inst. Bot. et Farmacol. Buenos Aires.”
 Distribution:— Endemic of Argentina; known only for the northwest of Tucumán province.
 Notes:— According to the protologue, types were deposited at B (the Wilhelm Becker Viola herbarium, “herb. W. Bckr. ”, which was acquired by the Botanical Museum Berlin- Dahlem, B, in 1929 [Hiepko 1987]), BAF (the herbarium of the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires, which Becker referred to as “Inst. Bot. et Farmacol. Buenos Aires ”), and LIL (the herbarium of the Miguel Lillo Foundation, which Becker referred to as “ M. Lillo ”); the first was destroyed during World War II (Robert Vogt pers. comm.; Hiepko 1987) and the second was not located at BAF. We found the specimen deposited at LIL as “ex herbario Lillo nº 8262”; it was collected by León Castillón, not Miguel Lillo. We selected the specimen with the barcode number LIL 001870 as lectotype because it is an abundant and complete specimen, agrees with the protologue, and has two labels from BAF and LIL with clear notes handwritten by Castillón indicating its identification, location, and date of collection; it also has a label with the identification made by Becker in 1926.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on pages 154-156, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Shock Revival in Core-Collapse Supernovae: A Phase-Diagram Analysis
Creators: name: Gabay, Daniel
name: Balberg, Shmuel
name: Keshet, Uri
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We examine the conditions for the revival of the stalled accretion shock in core-collapse supernovae, in the context of the neutrino heating mechanism. We combine one dimensional simulations of the shock revival process with a derivation of a quasi-stationary approximation, which is both accurate and efficient in predicting the flow. In particular, this approach is used to explore how the evolution of the system depends on the shock radius, $R_S$, and velocity, $V_S$ (in addition to other global properties of the system). We do so through a phase space analysis of the shock acceleration, $a_S$, in the $R_S-V_S$ plane, shown to provide quantitative insights into the initiation of runaway expansion and its nature. In the particular case of an initially stationary ($V_S=0,\;a_S=0$) profile, the prospects for an explosion can be reasonably assessed by the initial signs of the partial derivatives of the shock acceleration, in analogy to a linear damped/anti-damped oscillator. If $\partial a_S/\partial R_S<0$ and $\partial a_S/\partial V_S>0$, runaway expansion will likely occur after several oscillations, while if $\partial a_S/\partial R_S>0$, runaway expansion will commence in a non-oscillatory fashion. These two modes of runaway correspond to low and high mass accretion rates, respectively. We also use the quasi-stationary approximation to assess the advection-to-heating timescale ratio in the gain region, often used as an explosion proxy. Indeed, this ratio does tend to $\sim1$ in conjunction with runaway conditions, but neither this unit value nor the specific choice of the gain region as a point of reference appear to be distinct conditions in this regard.
description: 22 pages, 13 figures, submitted to ApJ. Comments welcome
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury
Creators: name: Schuppe-Koistinen, Ina
name: Mikus, Maria
name: Bachmann, Julie
name: Fier, Ian
name: Kampf, Caroline
name: Gry, Marcus
name: Andrade, Raúl J.
name: Aklillu, Eleni
name: Makonnen, Eyasu
name: Perazzo, Hugo
name: Schwenk, Jochen M.
name: Arber, Nadir
name: Aderaye, Getachew
name: Poynard, Thierry
name: Drobin, Kimi
name: Lucena, M Isabel
name: Lindberg, Johan
name: Watkins, Paul B.
name: Roach, James
name: Uhlén, Mathias
name: Göpfert, Jens
name: Stephens, Camilla
name: Nilsson, Peter
name: Yimer, Getnet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Abstract Background & Aims The occurrence of drug‐induced liver injury ( DILI ) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI , we utilised an affinity proteomics strategy, where antibody suspension bead arrays were applied to profile plasma and serum samples from human DILI cases and controls. Methods An initial screening was performed using 4594 randomly selected antibodies, representing 3450 human proteins. Resulting candidate proteins together with proposed DILI biomarker candidates generated a DILI array of 251 proteins for subsequent target analysis and verifications. In total, 1196 samples from 241 individuals across four independent cohorts were profiled: healthy volunteers receiving acetaminophen, patients with human immunodeficiency virus and/or tuberculosis receiving treatment, DILI cases originating from a wide spectrum of drugs, and healthy volunteers receiving heparins. Results We observed elevated levels of cadherin 5, type 2 ( CDH 5) and fatty acid‐binding protein 1 ( FABP 1) in DILI cases. In the two longitudinal cohorts, CDH 5 was elevated already at baseline. FABP 1 was elevated after treatment initiation and seemed to respond more rapidly than alanine aminotransferase ( ALT ). The elevations were verified in the DILI cases treated with various drugs. In the heparin cohort, CDH 5 was stable over time whereas FABP 1 was elevated. Conclusions These results suggest that CDH 5 may have value as a susceptibility marker for DILI . FABP 1 was identified as a biomarker candidate with superior characteristics regarding tissue distribution and kinetics compared to ALT but likely with limited predictive value for the development of severe DILI . Further studies are needed to determine the clinical utility of the proposed markers.
Viola canobarbata Leybold 1866
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola canobarbata

description: Viola canobarbata Leybold (1866: 285)
 Type (lectotype, designated here):— CHILE. [VI Region:] Rancagua, Piedra lisa in hacienda del Principal, 9000 ft, February, F. Leybold s.n. (SGO 000003277 [digital image!]; isolectotype, SI 004355!).
 Distribution:— Native of Argentina and Chile. In Argentina it is a dubious taxon until locate the specimen identified as Viola canobarbata Leybold (1866: 285) var. albiflora W. Becker (1925b: 360), collected by Carlos Spegazzini at Cerro de los Cordobeses, Mendoza, Argentina, on January 1906.
 Protologue citation:—“Mense Februario capsulas maturas floresque simul exhibit; circiter 9000´supra mare in glareosis ad locum, “Piedra lisa” dictu, in “hacienda del Principal” prov. “Rancagua”.
 Notes:—Friedrich Leybold settled in Chile from 1855 onwards (Stafleu & Cowan 1979). It is not known where he deposited his herbarium material and types, but type materials collected by Leybold between 1854 and 1890 were deposited at SGO (Stafleu & Cowan 1979; Muñoz-Schick et al. 2012) without evidence that duplicates were sent or not to other herbaria. Given the uncertainty that duplicates may exist in other herbaria, we found the specimen with the barcode number SGO 000003277 in the National Museum of Natural History, Santiago, Chile, and selected it as the lectotype since is a vigorous and complete specimen, agrees with the protologue, and has a label with clear notes handwritten by Leybold himself indicating the location and the identification.
 Following the International Code of Nomenclature (Art. 60.9; the use of a hyphen in a compound epithet is treated as an error to be corrected by deletion of the hyphen), the correct spelling of the specific epithet is “canobarbata ” and not “cano-barbata ” as in its original publication (Leybold 1866). Many competent modern authors of basic reference works spell the epithet correctly without the hyphen (e.g. Marticorena & Quezada 1985; Hoffmann et al. 1998; The Plant List 2013). However, it is still published with the erroneous hyphen in a few influential works and by many sources (e.g. Sanso et al. 2008; The International Plant Names Index 2012).
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on page 156, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Viola columnaris Skottsberg 1916
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola columnaris

description: Viola columnaris Skottsberg (1916: 261)
 Type (lectotype, designated here):—[ARGENTINA. Chubut:] Patagonia andina, sandy meseta north of Frías [or Cisnes] valley, 1000 m, 17 November 1908, C. Skottsberg 584 (S07-15250 [digital image!]).
 Protologue citation:—“ Subandines und andines Patagonien: trockene Meseta nö. Vom Valle Frias c. 1000 m (Bl. 2, 17. 11. 08); Valle Frias, Abhang des Cerro Cáceres, c. 800 m (Bl. 19. 11. 08); Terr. Chubut, 44º 24’ s., 71º 22’ w., leg. J. Högberg, Herb. Holm. s.n. V. portulacea.”
 Distribution:— Endemic of Argentina; known for the provinces of Chubut, Mendoza, Neuquén, and Río Negro.
 Notes:—Carl Skottsberg gave a detailed diagnosis of Viola columnaris, and he mentioned three collections, two by himself and another by Johan Högberg. Of these, we selected as lectotype the specimen collected by Skottsberg which bears the barcode number S07-15250, as it is located at one of the herbaria where he deposited his type material (Stafleu & Cowan 1985), it matches the protologue, and it possess several flowers in good condition. Additionally, this specimen was seen and identified by Wilhelm Becker, the main specialist of Viola, in 1925. The other syntype we examined was: ARGENTINA. Chubut: [Dept. Tehuelches, near Río Pico], 600 m, 28 January 1902, 44º 24’ S, 71º 22’ W, J. Högberg s.n. (S-R-11463 [digital image!], SI 003780!).
 In relation with the type locality, the Frías river (or Cisnes river as alternatively known) communicates Argentina with Chile through the Río Frias-Río Cisnes international border crossing. According to the report of Skottsberg (1911) in his book “The wilds of Patagonia” it is difficult to state whether this collection was made on the Argentine or the Chilean side of the Andes since he and his fellow travelers were exploring the valleys from one side to another during various days. It is worth noting that all subsequent records of Viola columnaris were made in the provinces of Chubut, Mendoza, Neuquén, and Río Negro, in Argentina, and no new collections are known for Chile. Because of this, we define that the type locality is on the Argentine side of the Andes.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on page 156, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Resonant oscillations of GeV - TeV neutrinos in internal shocks from gamma-ray burst jets inside the stars
Creators: name: Fraija, Nissim
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: High-energy neutrinos generated in collimated jets inside the progenitors of gamma-ray bursts (GRBs) have been related with the events detected by IceCube. These neutrinos, produced by hadronic interactions of Fermi-accelerated protons with thermal photons and hadrons in internal shocks, are the only signature when jet has not broken out or failed. Taking into account that the photon field is thermalized at keV energies and the standard assumption that the magnetic field maintains a steady value throughout the shock region (with a width of $10^{10} - 10^{11}$ cm in the observed frame), we study the effect of thermal and magnetized plasma generated in internal shocks on the neutrino oscillations. We calculate the neutrino effective potential generated by this plasma, the effects of the envelope of the star, and the vacuum on the path to Earth. By considering these three effects, the two (solar, atmospheric and accelerator parameters) and three neutrino mixing, we show that although GeV - TeV neutrinos can oscillate resonantly from one flavor to another, a nonsignificant deviation of the standard flavor ratio (1:1:1) could be expected on Earth.
description: Accepted in MNRAS (17 Pages, 12 figures)
Viola comberi W. Becker 1928
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola comberi

description: Viola comberi W. Becker (1928: 136)
 Type:— ARGENTINA. [Neuquén:] Cerro Colohuincul, between San Martín de los Andes and Lago Huechulaufquen, 2100 m, December 1926, H.F. Comber 882 (holotype, K [missing]; lectotype, designated here E 00322371 [digital image!]).
 Protologue citation:— “Argentina, 40º S:Cerro Colohuincul,between San Martin de losAndes and Lago Huechulafquen, 2100 m., Dec. 1926, H. F. Comber 882 (type in Herb. Kew.)”.
 Distribution:— Endemic of Argentina; known only for the southwest of Neuquén province.
 Notes:—The type collection of this species at K is actually lost (Mariel Sanso and Cecilia Xifreda pers. comm.). Therefore, we selected as lectotype the specimen with the barcode number E 00322371, which is in perfect condition and fully agrees with the protologue of Viola comberi.
 Rossow (1988) erroneously synonymized Viola comberi under V. cotyledon. These two taxa are quite distinct as V. comberi is a species with small corollas less than 1 cm long, which are yellow with purple veins, while V. cotyledon has bigger corollas more than 1 cm long, whitish to purplish. We consider V.comberi as an independent species although similar to V. coronifera, both with yellow flowers of similar size.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on page 157, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Reduced impact of renal failure on the outcome of patients with alcoholic liver disease undergoing liver transplantation
Creators: name: Bataller, Ramon
name: Cheong, Jaeyoun
name: Cabezas, Joaquin
name: Lucey, Michael R.
name: Hayashi, Paul H.
name: Ndugga, Nambi J.
name: Arora, Sumant
name: Barritt, Alfred Sidney
name: Galanko, Joseph A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Pre-transplant renal failure is commonly reported to be a poor prognostic indicator affecting survival after liver transplantation (LT). However, whether the impact of renal failure on patient outcome varies according to the etiology of the underlying liver disease is largely unknown.
Call to action for global access to and harmonization of quality information of individual earth science datasets
Creators: name: Peng, Ge
name: Downs, Robert R.
name: Lacagnina, Carlo
name: Ramapriyan, Hampapuram
name: Ivánová, Ivana
name: Moroni, David
name: Wei, Yaxing
name: Larnicol, Gilles
name: Wyborn, Lesley
name: Goldberg, Mitch
name: Schulz, Jörg
name: Bastrakova, Irina
name: Ganske, Anette
name: Bastin, Lucy
name: Khalsa, Siri Jodha S.
name: Wu, Mingfang
name: Shie, Chung-Lin
name: Ritchey, Nancy
name: Jones, Dave
name: Habermann, Ted
name: Lief, Christina
name: Maggio, Iolanda
name: Albani, Mirko
name: Stall, Shelley
name: Zhou, Lihang
name: Drévillon, Marie
name: Champion, Sarah
name: Hou, C. Sophie
name: Doblas-Reyes, Francisco
name: Lehnert, Kerstin
name: Robinson, Erin
name: Bugbee, Kaylin
Publisher: name: Paris : CODATA
Year: 2021
Subjects: subject: Data Quality
subject: Earth Science Information
subject: FAIR
subject: Interoperability
subject: Quality Dimension
subject: Stewardship
subject: 500

description: Knowledge about the quality of data and metadata is important to support informed decisions on the (re)use of individual datasets and is an essential part of the ecosystem that supports open science. Quality assessments reflect the reliability and usability of data. They need to be consistently curated, fully traceable, and adequately documented, as these are crucial for sound decision- and policy-making efforts that rely on data. Quality assessments also need to be consistently represented and readily integrated across systems and tools to allow for improved sharing of information on quality at the dataset level for individual quality attribute or dimension. Although the need for assessing the quality of data and associated information is well recognized, methodologies for an evaluation framework and presentation of resultant quality information to end users may not have been comprehensively addressed within and across disciplines. Global interdisciplinary domain experts have come together to systematically explore needs, challenges and impacts of consistently curating and representing quality information through the entire lifecycle of a dataset. This paper describes the findings of that effort, argues the importance of sharing dataset quality information, calls for community action to develop practical guidelines, and outlines community recommendations for developing such guidelines. Practical guidelines will allow for global access to and harmonization of quality information at the level of individual Earth science datasets, which in turn will support open science.
High MIG (CXCL9) plasma levels favours response to peginterferon and ribavirin in HCV-infected patients regardless of DPP4 activity
Creators: name: Tuefferd, Marianne
name: Talloen, Willem
name: Johansson, Susanne
name: Fried, Michael W.
name: Fanning, Gregory
name: Darling, Jama
name: Aerssens, Jeroen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Sustained virological response (SVR) following peginterferon (pegIFN) and ribavirin (RBV) treatment in hepatitis C virus (HCV) infected patients has been linked with the IL28B genotype and lower peripheral levels of the CXCR3-binding chemokine IP-10 (CXCL10). To further improve the understanding of these biomarkers we investigated plasma levels of the other CXCR3-binding chemokines and activity of the dipeptidyl peptidase IV (DPP4, CD26) protease, which cleaves IP-10, in relation to treatment response.
Cu2Zn(Sn,Ge)Se4 solar cells fabricated from Zn/Cu3Sn/Cu6Sn5 precursors with GeSe2-x and SnSe2-x vapor supply during the reactive annealing
Creators: name: Khonsor, Talat
name: Nowak, David
name: Gütay, Levent
Publisher: name: Zenodo
Year: 2023

description: Kesterite+ Workshop 2023 Barcelona Poster; In previous studies the Ge-free precursor stack (Zn/Cu3Sn+Cu6Sn5/Zn) was optimized and the role of
 Cu-Sn alloy ratios and the composition shift by incorporation of SnSe2-x vapor was investigated.[1,2] The
 results indicate, that starting the process at different precursor compositions and alloy configurations
 impacts the Cu2ZnSnSe4 formation path. However, similar finals absorber compositions can be achieved
 by tuning the composition shift during the reactive annealing step.[2]
 Earlier studies on incorporation of Ge into the absorbers via GeSe2-x vapor indicated a combined
 composition shift in terms of Sn & Ge content with improvements of the long-term device stability.[3]
 In this study we focus on the absorber growth starting at previously identified optimum precursor
 configurations and investigate the impact of varied Sn/Ge incorporation ratios on the resulting device
 properties.
Self-consistent modelling of line-driven hot-star winds with Monte Carlo radiation hydrodynamics
Creators: name: Noebauer, U. M.
name: Sim, S. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Radiative pressure exerted by line interactions is a prominent driver of outflows in astrophysical systems, being at work in the outflows emerging from hot stars or from the accretion discs of cataclysmic variables, massive young stars and active galactic nuclei. In this work, a new radiation hydrodynamical approach to model line-driven hot-star winds is presented. By coupling a Monte Carlo radiative transfer scheme with a finite-volume fluid dynamical method, line-driven mass outflows may be modelled self-consistently, benefiting from the advantages of Monte Carlo techniques in treating multi-line effects, such as multiple scatterings, and in dealing with arbitrary multidimensional configurations. In this work, we introduce our approach in detail by highlighting the key numerical techniques and verifying their operation in a number of simplified applications, specifically in a series of self-consistent, one-dimensional, Sobolev-type, hot-star wind calculations. The utility and accuracy of our approach is demonstrated by comparing the obtained results with the predictions of various formulations of the so-called CAK theory and by confronting the calculations with modern sophisticated techniques of predicting the wind structure. Using these calculations, we also point out some useful diagnostic capabilities our approach provides. Finally we discuss some of the current limitations of our method, some possible extensions and potential future applications.
description: 15 pages, 8 figures; accepted for publication in MNRAS
Viola evae var. flossdorfii Nicola 2018, comb. nov.
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola evae
Viola evae hieronymus ex w. becker (1922a: 182) var. flossdorfii (hicken 1922: 31) nicola

description: Viola evae Hieronymus ex W. Becker (1922a: 182) var. flossdorfii (Hicken 1922: 31) Nicola, comb. nov.
 Basionym: Viola flos-evae Hieronymus nomen nudum, pro syn. var. flossdorfii Hicken (1922: 31).
 Type:— ARGENTINA. La Rioja: Sierra Famatina, Quebrada Encrucijada, 3500–5000 m, March 1913, A. Flossdorf 39 (holotype, SI 003757!).
 Protologue citation:—“En la Quebrada.”
 Distribution:—Endemic of La Rioja province, Argentina.
 Notes:—Cristóbal Hicken published “ Viola flos-evae Hieronymus var. flossdorfii Hicken ” and mentioned that he never found the original description of “ Viola flos-evae Hieronymus ”. In fact, as explained above, that description never existed. Consequently, we effect the new combination herein.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on page 160, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
The transformation in biomarker detection and management of drug-induced liver injury
Creators: name: Church, Rachel J.
name: Watkins, Paul B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Drug-induced liver injury (DILI) is a major concern for patients, care givers and the pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and monitor DILI, which have not changed in almost 50 years, can be improved with recently proposed models employing quantitative systems pharmacology. In addition, several newer serum biomarkers are showing great promise. Studies in rodents indicate that the ratio of the caspase cleaved fragment of cytokeratin 18 to total K18 in serum (termed the “apoptotic index”) estimates the relative proportions of apoptosis vs necrosis during drug-induced liver injury. Glutamate dehydrogenase can reliably differentiate liver from muscle injury and, when serum is properly prepared, may also detect mitochondrial toxicity as a mechanism of liver injury. MicroRNA-122 is liver-specific, but recent data suggests it can be actively released from hepatocytes in the absence of overt toxicity limiting enthusiasm for it as a DILI biomarker. Finally, damage associated molecular patterns, particularly high mobility group box 1 and its various modified forms, are promising biomarkers of innate immune activation, which may be useful in distinguishing benign elevations in aminotransferases from those that portend clinically important liver injury. These new biomarkers are already being measured in early clinical trials, but broad acceptance will require widespread archiving of serum from diverse clinical trials and probably pre-competitive analysis efforts. We believe that utilization of a panel of traditional and newer biomarkers in conjunction with quantitative systems pharmacology modeling approaches will transform DILI detection and risk management.
Viola hieronymi W. Becker 1922
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola hieronymi

description: Viola hieronymi W. Becker (1922a: 185)
 Type:— ARGENTINA. La Rioja: Sierra Famatina, en las cercanías de la Mina Jareta, 25 January 1879, G. Hieronymus & G. Niederlein 804 (holotype, B [destroyed]; lectotype, designated here CORD 00003354 [digital image!]; isolectotype, SI 003773!).
 Protologue citation:—“ Exs. Hieronymus et Niederlein Flora Argentina no. 804: Prov. de la Rioja, Sierra Famatina 1. en las cercanías de la mina Jareta, fl. 25. I. 1879; 2. entre la mina la Jareta y la altura del Espiritu Santo, fl. 25. I. 1879 (Herb. Mus. bot. Berol.).”
 Distribution:—Endemic of La Rioja province, Argentina.
 Notes:—Evidently there were three specimens with the same number which were deposited in different herbaria, as we have also found specimens at CORD and SI. The B holotype is destroyed (Robert Vogt pers. comm.), so we selected the specimen with the barcode number CORD 00003354 as the lectotype of the species because it is an abundant and complete specimen, agrees with the protologue, and provides a label with clear annotations handwritten by Georg Hieronymus.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on pages 163-164, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Interferon-free therapy for genotype 1 hepatitis C in liver transplant recipients: Real-world experience from the hepatitis C therapeutic registry and research network.
Creators: name: Reddy, K. Rajender
name: Terrault, Norah A.
name: O'Leary, Jacqueline G.
name: Stravitz, R. Todd
name: Stewart, Thomas G.
name: Morelli, Giuseppe J.
name: Kwo, Paul
name: Burton, James R.
name: Frenette, Catherine T.
name: Kuo, Alexander
name: Fried, Michael W.
name: Durand, Christine
name: Brown, Robert S.
name: Di Bisceglie, Adrian M.
name: Nelson, David R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Recurrent infection with the hepatitis C virus (HCV) after liver transplantation (LT) is associated with decreased graft and patient survival. Achieving sustained virological response (SVR) with antiviral therapy improves survival. Because interferon (IFN)-based therapy has limited efficacy and is poorly tolerated, there has been rapid transition to IFN-free direct-acting antiviral (DAA) regimens. This article describes the experience with DAAs in the treatment of posttransplant genotype (GT) 1 HCV from a consortium of community and academic centers (Hepatitis C Therapeutic Registry and Research Network [HCV-TARGET]). Twenty-one of the 54 centers contributing to the HCV-TARGET consortium participated in this study. Enrollment criteria included positive posttransplant HCV RNA before treatment, HCV GT 1, and documentation of use of a simeprevir (SMV)/sofosbuvir (SOF) containing DAA regimen. Safety and efficacy were assessed. SVR was defined as undetectable HCV RNA 64 days or later after cessation of treatment. A total of 162 patients enrolled in HCV-TARGET started treatment with SMV+SOF with or without ribavirin (RBV) following LT. The study population included 151 patients treated with these regimens for whom outcomes and safety data were available. The majority of the 151 patients were treated with SOF and SMV alone (n = 119; 79%) or with RBV (n = 32; 21%), The duration of therapy was 12 weeks for most patients, although 15 patients received 24 weeks of treatment. Of all patients receiving SOF/SMV with or without RBV, 133/151 (88%) achieved sustained virological response at 12 weeks after therapy and 11 relapsed (7%). One patient had virological breakthrough (n = 1), and 6 patients were lost to posttreatment follow-up. Serious adverse events occurred in 11.9%; 3 patients (all cirrhotic) died due to aspiration pneumonia, suicide, and multiorgan failure. One experienced LT rejection. IFN-free DAA treatment represents a major improvement over prior IFN-based therapy. Broader application of these and other emerging DAA regimens in the treatment of posttransplant hepatitis C is warranted.
Tunable excitonic insulator in quantum limit graphite
Creators: name: Zhu, Z.
name: McDonald, R. D.
name: Shekhter, A.
name: Ramshaw, B. J.
name: Modic, K. A.
name: Balakirev, F. F.
name: Harrison, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Half a century ago, Mott noted that tuning the carrier density of a semimetal towards zero produces an insulating state in which electrons and holes form bound pairs. It was later argued that such pairing persists even if a semiconducting gap opens in the underlying band structure, giving rise to what has become known as the strong coupling limit of an `excitonic insulator.' While these `weak' and `strong' coupling extremes were subsequently proposed to be manifestations of the same excitonic state of electronic matter, the predicted continuity of such a phase across a band gap opening has not been realized experimentally in any material. Here we show the quantum limit of graphite, by way of temperature and angle-resolved magnetoresistance measurements, to host such an excitonic insulator phase that evolves continuously between the weak and strong coupling limits. We find that the maximum transition temperature T_EI of the excitonic phase is coincident with a band gap opening in the underlying electronic structure at B_0= 46 +/- 1 T, which is evidenced above T_EI by a thermally broadened inflection point in the magnetoresistance. The overall asymmetry of the observed phase boundary around B_0 closely matches theoretical predictions of a magnetic field-tuned excitonic insulator phase in which the opening of a band gap marks a crossover from predominantly momentum-space pairing to real-space pairing.
description: 11 pages, including 4 figures
Viola lilloana W. Becker 1926
Creators: name: Nicola, Marcela Viviana
name: Salomón, Luciana
name: Zuloaga, Fernando Omar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Violaceae
Viola
Viola lilloana

description: Viola lilloana W. Becker (1926a: 225)
 Type (lectotype, designated here):— ARGENTINA. Tucumán: El Cajón, 4400 m, 17 January 1914, L. Castillón 3311 ( M. Lillo sub. No. 16166 ) (BAF 6305!; isolectotypes, B [destroyed], LIL 001871 [digital image!], LIL 001872 [digital image!]). (Fig. 4)
 Protologue citation:— “Argentina: Prov. Tucumán, El Cajón, 4400 m, 17. I. 1914 leg. M. Lillo sub. No. 16166. Typus in herb. W. Bckr. et Inst. Botan. et Farmacol. Buenos Aires.”
 Distribution:—Endemic of the province of Tucumán, Argentina.
 Notes:—According to the protologue, Wilhelm Becker mentioned type material deposited at B (the Becker Viola herbarium, “herb. W. Bckr.”, which was acquired by the Botanical Museum Berlin-Dahlem, B, in 1929 [Hiepko 1987]) and BAF (the herbarium of the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires, which Becker referred to as “Inst. Brot. et Farmacol. Buenos Aires). The material deposited at B was destroyed (Robert Vogt pers. comm.). In consequence, we selected the specimen with the herbarium reference number BAF 6305 as the lectotype of Viola lilloana because it is a discrete but complete specimen, agrees with the protologue, possesses an original label with clear notes handwritten by Castillón indicating the location and date of collection, and a label added later with the identification made in 1926 by Becker.
description: Published as part of Nicola, Marcela Viviana, Salomón, Luciana & Zuloaga, Fernando Omar, 2018, Nomenclatural and taxonomic study in species of Viola (Violaceae) from Argentina, pp. 151-176 in Phytotaxa 338 (2) on page 164, DOI: 10.11646/phytotaxa.338.2.1, http://zenodo.org/record/13719903
Metabolomics and Integrative Omics: from data production to analysis
Creators: name: Tenori, Leonardo
name: Dragsted, Lars Ove
name: Savoi, Stefania
name: Fochi, Igor
name: Franceschi, Pietro
name: Cavalieri, Duccio
name: Steinbeck, Christoph
name: Ghini, Veronica
name: Porro, Danilo
name: Timperio, Anna Maria
name: Fosso, Bruno
name: Mastrorocco, Fabrizio
name: Gaglio, Daniela
name: Fanelli, Giuseppina
name: Giannattasio, Sergio
name: Musicco, Clara
Publisher: name: Zenodo
Year: 2022
Subjects: Metabolomics
Integrative Omics
Open Data
Open Science
ELIXIR-IT
ELIXIR IIB
Training
Biomarker
Food Biomarkers
Data Management
Metadata Management
FAIR
Data Elaboration
LC-MS metabolomics
Databases for Metabolomics
ELIXIR Italy

description: Presentations given during the workshop "Metabolomics and Integrative Omics: from data production to analysis", on April 28th-29th 2022, Bari.
Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus
Creators: name: Dooley,
name: Schwarting,
name: Thompson,
name: Wilson,
name: Roth,
name: Edwards,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Practicing physicians have requested efficacy and safety data for belimumab, when used with specific systemic lupus erythematosus (SLE) medications. This was a post hoc analysis of pooled efficacy and safety data from patients who received belimumab 10 mg/kg plus standard of care (SoC) or placebo (SoC) in two Phase III, randomized trials, BLISS-52 and BLISS-76. Patients were categorized into four groups based on baseline concomitant medication usage: steroids only; antimalarials (AM) only; steroids + AM; or steroids + AM + immunosuppressants (IS). The primary endpoint was the SLE Responder Index (SRI) at Week 52. SRI over time and individual SRI components were secondary endpoints. Time to first flare and changes in concomitant medications were exploratory endpoints. Safety was assessed using adverse event (AE) reporting. Across 834 patients, steroids + AM was the largest group (n = 346, 41.5%) and AM only was the smallest (n = 77, 9.2%). Disease duration was shortest in the steroids + AM group (5.7 years vs 6.4–7.1 years); SELENA-SLEDAI scores were similar across groups. At Week 52, the percentage of SRI responders was greatest in the steroids + AM group for belimumab 10 mg/kg (59%) compared with placebo (44%); treatment response and SRI component improvements were also observed across other groups. The probability of experiencing an SLE flare was reduced in the steroids-only group for patients who received belimumab 10 mg/kg compared with placebo (64.3% vs 78.1%; hazard ratio 0.64; 95% confidence interval: 0.42–0.96). There was little or no change in daily AM or IS dose in any group. For all groups, there was a general decrease in steroid dose over time; a quarter to a third of patients experienced decreased steroid doses at Week 52. The overall safety profile was similar across treatment arms and concomitant medication groups, with the exception of serious AEs in the steroids + AM group (belimumab 10 mg/kg 16%, placebo 8%). The efficacy and safety of belimumab in combination with SoC was demonstrated for various groupings of steroids, AM and IS. These findings may improve the understanding of the safety and efficacy of adding belimumab to different treatments.
BIGG D7.2- Update of contributions to standardization actions and preliminary Market2Go strategy including BIGG impact
Creators: name: Papakonstantinou, Athanasios
name: Picinbono, Guillaume
name: Redmond, Alan
name: Bus, Nicolas
name: Carbonell, Jordi
name: Lehanneur, Pierre
name: Gomez, Nerea
name: Paraschi, Marion
name: Arvaniti, Eirini
Publisher: name: Zenodo
Year: 2023
Subjects: standardization
standardization bodies
exploitation
market analysis
BIM
SAREF
DEEP
INSPIRE
AIOTI
ISO
CEN
ESCO
EPC
energy efficiency
renewable energy
BMS
CMMS

description: The purpose of this document is to present the work done and the results achieved in work package 7 during the first two years of the project.
 The main objective of WP7 is to provide the project with an effective exploitation and deployment strategy. It will support the developments by providing a clear picture of needs, requirements and standardization framework. WP7 has the following specific objectives:
 • Create a long-term collaboration framework with standardization bodies to which BIGG can technically contribute,
 • Characterize the markets, the stakeholders and their needs,
 • Assess the outstanding features of our exploitable results providing us with a market advantage,
 • Manage, protect and find agreements on the exploitable results,
 • Assess, discern and propose business models capable of empowering the commercial and technical offerings,
 • Set forward dedicated plans for commercialization and market uptake for each exploitable result contemplating the appropriate business models.
 The document is divided into 2 main parts:
 • First part presents the updated version of contributions to standardization actions.
 • Second part focuses on the Market Analysis of BIGG Use Cases and on the description of BIGG Exploitable Results, implementing the first and second steps of the BIGG exploitation strategy.
HOW CAN WE MANAGE WATER RESOURCES IN INDIA
Creators: name: Hitendra R. Aher
Publisher: name: Zenodo
Year: 2022

description: Introduction:  India with an area of 3287263 km2 is the seventh largest country in world and by population it ranks at number two after China. Since Independence, India has made significant progress in developing its water resources and supporting infrastructure. Water is a key driver of social and economic development while it also has a basic function in maintaining the integrity of the natural environment. However, water is only one of a number of vital natural resources and it is imperative that water issues are not considering isolation. Water is fundamental to life, livelihood, food security and sustainable development. India has more that 17% of world’s population, 2.4% of world’s land area but has only 4% of world’s renewable water resources. Water is essential for sustaining all forms of life, food production, and economic development and for general wellbeing. It is impossible to substitute for most of its uses, difficult to de-pollute, expensive to transport and it is truly a unique gift to humanity from nature. Water is also one of the most manageable of the natural resources as it is capable of diversion, transport, and storage and recycling. All these properties impart to water its great utility for human being.
Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator
Creators: name: Roldan, Ariel
name: Bozoky, Zoltan
name: Forman-Kay, Julie
name: Gakhal, Amandeep K.
name: Jensen, Timothy J.
name: Lukacs, Gergely L.
name: Riordan, John R.
name: Sidhu, Sachdev S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel in the apical surface of epithelial cells in the airway and gastrointestinal tract, and mutation of CFTR is the underlying cause of cystic fibrosis. However, the precise molecular details of the structure and function of CFTR in native and disease states remains elusive and cystic fibrosis researchers are hindered by a lack of high specificity, high affinity binding reagents for use in structural and biological studies. Here, we describe a panel of synthetic antigen-binding fragments (Fabs) isolated from a phage-displayed library that are specific for intracellular domains of CFTR that include the nucleotide-binding domains (NBD1 and NBD2), the R-region, and the regulatory insertion loop of NBD1. Binding assays performed under conditions that promote the native fold of the protein demonstrated that all Fabs recognized full-length CFTR. However, only the NBD1-specific Fab recognized denatured CFTR by western blot, suggesting a conformational epitope requirement for the other Fabs. Surface plasmon resonance experiments showed that the R-region Fab binds with high affinity to both the phosphorylated and unphosphorylated R-region. In addition, NMR analysis of bound versus unbound R-region revealed a distinct conformational effect upon Fab binding. We further defined residues involved with antibody recognition using an overlapping peptide array. In summary, we describe methodology complementary to previous hybridoma-based efforts to develop antibody reagents to CFTR, and introduce a synthetic antibody panel to aid structural and biological studies.
Search for heavy Majorana neutrinos with the ATLAS detector in pp collisions at $\sqrt{s} = 8$ TeV
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for heavy Majorana neutrinos in events containing a pair of high-$p_{\mathrm{T}}$ leptons of the same charge and high-$p_{\mathrm{T}}$ jets is presented. The search uses $20.3 \mathrm{fb}^{-1}$ of $pp$ collision data collected with the ATLAS detector at the CERN Large Hadron Collider with a centre-of-mass energy of $\sqrt{s} = 8$ TeV. The data are found to be consistent with the background-only hypothesis based on the Standard Model expectation. In the context of a Type-I seesaw mechanism, limits are set on the production cross-section times branching ratio for production of heavy Majorana neutrinos in the mass range between 100 and 500 GeV. The limits are subsequently interpreted as limits on the mixing between the heavy Majorana neutrinos and the Standard Model neutrinos. In the context of a left-right symmetric model, limits on the production cross-section times branching ratio are set with respect to the masses of heavy Majorana neutrinos and heavy gauge bosons $W_{\mathrm{R}}$ and $Z'$.
description: 28 pages plus author list (44 pages total), 11 figures, 6 tables, submitted to JHEP, all figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2012-24/
Advancing Reversible Shape Memory by Tuning the Polymer Network Architecture
Creators: name: Zhou, Jing
name: Li, Qiaoxi
name: Vatankhah-Varnoosfaderani, Mohammad
name: Nykypanchuk, Dmytro
name: Sheiko, Sergei S.
name: Gang, Oleg
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Because of counteraction of a chemical network and a crystalline scaffold, semicrystalline polymer networks exhibit a peculiar behavior—reversible shape memory (RSM), which occurs naturally without applying any external force and particular structural design. There are three RSM properties: (i) range of reversible strain, (ii) rate of strain recovery, and (iii) decay of reversibility with time, which can be improved by tuning the architecture of the polymer network. Different types of poly(octylene adipate) networks were synthesized, allowing for control of cross-link density and network topology, including randomly cross-linked network by free-radical polymerization, thiol–ene clicked network with enhanced mesh uniformity, and loose network with deliberately incorporated dangling chains. It is shown that the RSM properties are controlled by average cross-link density and crystal size, whereas topology of a network greatly affects its extensibility. In conclusion, we have achieved 80% maximum reversible range, 15% minimal decrease in reversibility, and fast strain recovery rate up to 0.05 K –1, i.e., ca. 5% per 10 s at a cooling rate of 5 K/min.