cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Piacenza verso la valorizzazione del patrimonio immobiliare militare dismesso
Piacenza towards the valorisation of the dismissed military property asset
Creators: name: Milani, Michela; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR20 - Tecnica e pianificazione urbanistica
patrimonio immobiliare militare dismesso; valorizzazione; riqualificazione urbana, architettonica e ambientale; interazioni pubblico-privato; Piacenza; Comparto Nord San Sisto/Cittadella;
ICAR20 - Urban studies and town planning
valorisation; dismissed military property assets; urban, architectural and environmental restoration; interactions between public and private sectors; Piacenza; Comparto Nord San Sisto/Cittadella;

description: Recentemente è stata ancora ribadita dal Ministero della Difesa l’importanza del processo di valorizzazione del patrimonio immobiliare militare dismesso. Gli effetti critici connessi alla dismissione di questi immobili possono – e devono – essere interpretati in termini di opportunità di ampio respiro: riqualificazione urbana, architettonica e ambientale; rilancio della città e del suo territorio; sostenibilità; partecipazione e concertazione; interazioni sinergiche tra pubblico e privato. Piacenza è tra le realtà maggiormente investite da questi processi; il dibattito pubblico sul futuro delle aree militari è aperto, specialmente per le Caserme Bixio e Nicolai (Comparto Nord San Sisto/Cittadella), sede storica del Genio Pontieri che dovrebbe essere il primo dei siti da valorizzare.
description: Recently, the importance of the process of valorisation of dismissed military property assets has been confirmed again by the Italian Ministry of Defense. The critical effects related with the dismission of these properties can - and should - be interpreted in terms of broad opportunities: urban, architectural and environmental restoration; revitalization of the city and its territory; sustainability; participation and consultation; synergistic interactions between public and private sectors. Piacenza is one of the towns most involved in these processes; the public debate on the future of military areas is open, especially on Barracks Bixio and Nicolai (Comparto Nord San Sisto/Cittadella), the historical site of the Genio Pontieri which should be the first to be valorised.
Magic bullets, mates or myths: who are the mentors?
Creators: name: Tye, Marian
name: Gillin, Murray
Publisher: name: Swinburne
Year: 2024

description: To date, by far the bulk of mentoring literature reflects activity in intra-organisational and corporate environments. In 2000 it was estimated that over a third of the major U.S. corporations had established formal mentor programs (Nemanick, 2000). The rise of the mentor is often seen as coinciding with the rise of the human resource development movement and achieved prominence in the period 1975 - 1990 (Monaghan and Lunt, 1992) and interest in mentoring was significantly boosted with the introduction of equal employment opportunity legislation, when mentor programs were identified as a means of addressing opportunities for women and individuals in minority groups. The available literature is largely organisation-centric and portrays mentoring as the best (and sometimes worst) thing to happen in career development. The majority of references relate to formal mentoring programs. However, entrepreneurial research has, over time, identified a number of particular factors which are believed to contribute to entrepreneurial success. Of particular interest to this research is the reference to mentors. Gartner et al. (1992) identified one of the factors contributing to the likelihood of success of the entrepreneur was the amount of time and the intensity devoted to specific activities including finding mentors. Authors such as Hisrich (1989) and Timmons and Spinelli (2004) recommend entrepreneurs use mentors, advisors or form quasi-boards to gain valuable counsel and advice from outsiders. However few studies have examined the relationship of the mentor and the entrepreneur. Despite this, the concept of mentoring is increasingly applied to sources of assistance advocated for nascent entrepreneurs. A process of discovery continues to explore the concepts of mentors and mentoring to better understand the role of significant others in the process of new venture creation. This paper builds on previous exploration of data.
MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators
Creators: name: Daoud, Afra Z
name: Mulholland, Eoghan J
name: Cole, Grace
name: McCarthy, Helen O
Publisher: name: BioMed Central
Year: 2019

description: A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern. The limited efficacy of current treatments necessitates the development of novel therapeutic strategies that are based on an understanding of the molecular mechanisms involved in pancreatic cancer progression. MicroRNAs (miRNAs) are non-coding small RNAs that regulate the expression of multiple proteins in the post-translation process and thus have promise as biomarkers, prognostic agents, and as advanced pancreatic therapies. Profiling of deregulated miRNAs in pancreatic cancer can correlate to diagnosis, indicate optimal treatment and predict response to therapy. Furthermore, understanding the main effector genes in pancreatic cancer along with downstream pathways can identify possible miRNAs as therapeutic candidates. Additionally, obstacles to the translation of miRNAs into the clinic are also considered. Distinct miRNA expression profiles can correlate to stages of malignant pancreatic disease, and hold potential as biomarkers, prognostic markers and clinical targets. However, a limited understanding and validation of the specific role of such miRNAs stunts clinical application. Target prediction using algorithms provides a wide range of possible targets, but these miRNAs still require validation through pre-clinical studies to determine the knock-on genetic effects.
Ipotesi progettuale di rigenerazione urbana: il caso di studio dell’ex Caserma Monti già Convento di S. Maria della Ripa nella città di Forlì
Hypothesis for an urban requalification project: case study of the former Caserma Monti (Monti barracks) which was already the Convento di S. Maria della Ripa in the town of Forlì
Creators: name: Castagnoli, Alessandro; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR14 - Composizione architettonica e urbana
dismissione; rigenerazione; città; storia; tipologia;
ICAR14 - Architectural and urban design
disposal; regeneration; city; history; typology;

description: Un’ampia area dismessa nel centro della città storica, è stata considerata l’opportunità strategica per valorizzare e rigenerare anche interi brani di tessuto urbano circostante con l’obiettivo di riammagliare gli sfrangiamenti materiali e immateriali nel complesso rapporto fra passato, presente e futuro.Questo caso di studio ha consentito di approfondire un approccio meta progettuale più generale, puntando sulla ricerca di una metodologia appropriata rispetto alla progettazione dello spazio architettonico in quanto tale, con l’obiettivo di sviluppare ragionamenti di compatibilità nell’ambito della vasta tematica del riuso urbano ed edilizio.
description: A large abandoned area in the centre of the historical part of the town was also considered to be a strategic opportunity for assessing and requalifying entire sections of the surrounding urban structure, with the aim of reworking the material and immaterial wear and tear in the complex relationship between past, present and future. The investigation allowed for the in-depth study of a more general approach, focussing on researching an appropriate methodology with regards to designing the architectural space and developing compatibility reasoning in the sphere of the vast issue of urban and building reuse.
Cloning msx and dlx homeobox-containing genes from the Mexican axolotl (Ambystoma mexicanum).
Creators: name: Nolte, Christof D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: The lateral line system is an unique sensory system found in fishes and amphibians. It is composed of two types of sensory organs: electroreceptors (ampullary organs) and mechanoreceptors (neuromasts). These organs are arranged in lines throughout the surface of the head and the body, and allow the animal to detect weak electric field and to sense motion in the immediate surroundings. We are interested in studying the genes involved in regulating the development of the hair cells of the neuromast organ because these hair cells are considered to be homologous to the hair cells of the vertebrate inner ear. When damaged by noise trauma, birds are capable of regenerating the hair cells of the inner ear whereas other vertebrates, such as humans, become permanently deaf. Since axolotl neuromasts are readily accessible to experimental manipulation and are capable of regeneration, they are an excellent model for studying the genes involved in the development and regeneration of hair cells. Two gene families that play extensive roles in pattern formation during embryonic development are the msx and dlx homeobox-containing genes. Members from both families are expressed in the developing hair cells of the zebrafish inner ear, and therefore are excellent candidates for regulating the development of the neuromast organs in axolotls. As a first step towards examining the expression of members of these two families in the axolotl, we have cloned the cDNA sequences of msx-1, msx-2, dlx-3, dlx-5, and dlx-7. In addition, we have cloned the homeobox portions of the axolotl dlx-1 and dlx-6 genes. We also provide evidence of two different transcripts for the axolotl dlx-3 gene suggesting the existance of two copies of this gene in the axolotl genome.
Riqualificazione e sviluppo del sito minerario di Balangero e Corio: una proposta per la miniera d’amianto più grande d’Europa
Urban renovation and development of the mining site of Balangero and Corio: a proposal for the largest asbestos mine in Europe
Creators: name: Giacobazzi, Luca; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR14 - Composizione architettonica e urbana
Balangero; Corio; sito minerario; amianto; crisotilo; concorso di idee; incubatore; riqualificazione;
ICAR14 - Architectural and urban design
Balangero; Corio; mining site; asbestos; chrysotile; idea competition; incubator; reclaiming;

description: Il Sito di bonifica di Interesse Nazionale di Balangero e Corio ha prodotto crisotilo a partire dal 1918 e negli anni ‘70 si è affermato come la miniera d’amianto più grande d’Europa, causando una notevole contaminazione dell’area.La miniera venne chiusa nel 1990 poiché il D.L. 257/92 vietò l’estrazione, l’importazione, l’esportazione, il commercio e la produzione dell’amianto.L’obiettivo del concorso non era solamente bonificare un’area contaminata, ma anche valorizzare la cultura e il paesaggio, preservare la memoria storica e promuovere iniziative che coinvolgano la popolazione locale riaffermando la forza sociale ed economica della regione.Il progetto propone la conversione degli edifici industriali in spazi di documentazione dedicati alla storia del sito, luoghi per la produzione e promozione dell’arte e una serie di strutture ricettive volte a stimolare differenti forme di turismo.
description: The National Interest Site for remediation of Balangero and Corio produced chrysotile from the 1918 and in the 1970s became the largest European asbestos mine, causing a considerable contamination of the area.The mine was closed in the 1990 because the D.L. 257/92 banned the extraction, import, export, marketing and production of asbestos.The objective of the competition was not only to reclaim a contaminated area, but also to enhance culture and landscape, to preserve the historical memory and to promote initiatives involving the local population to restore the economic and social strength of the region.The project proposes the conversion of the industrial buildings into spaces for documenting the mine history, places for production and promotion of arts and a range of accommodation aimed at developing different forms of tourism.
An analysis of a relaxation/stress control program in an alternative elementary school.
Creators: name: Taylor, Shaunna L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Education, Guidance and Counseling.

description: The purpose of this study was to implement and assess the effectiveness of Orlick's (1993) mental skills/life skills training program in an alternative elementary school. Four teachers of 85 students in multi-aged classes were instructed to modify the program however they saw fit, in order to have it meet the needs of their students. The alternative school classes were divided into multi-aged groupings of grade 1/2, 2/3, 4/5, and 6. The primary objectives of the study were to investigate (a) how teachers would make adaptations to the intervention program to suit their classroom environments, (b) how the teachers felt they were affected through their participation in the program, and (c) whether the students would increase their ability to relax themselves and improve their ability to identify and control stress. The results of this study showed the teachers made modifications to the intervention program on session and global levels, and reported personal gain from their participation. The students showed significant and positive results in their ability to relax, as indicated in pre- and post-intervention heart rate test scores using the HR monitor DT 1000, and in their ability to identify and control stress as indicated by logbook analysis. The teacher results will be used as a blueprint for further refinement to the Orlick (1993) intervention program curriculum and delivery.
Supplementary document for Efficient scattering model of multi-layer systems with anisotropic films - 5157383.pdf
Creators: name: Gill, Jordan
name: Perivolari, Elena
name: Kaczmarek, Malgosia
name: Alessandro, Giampaolo D
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document.
Balanced skills among nascent entrepreneurs
Creators: name: Stuetzer, Michael
name: Kaya, Maria
Publisher: name: Swinburne
Year: 2024

description: This paper examines the effects and origins of balanced skills among nascent entrepreneurs. In a first step we extend Lazear’s jack-of-all-trades theory to formally model performance effects of balanced skills. In a second step we investigate potential sources of balanced skills related to the investment hypothesis and the endowment hypothesis. Analyzing data on 100 high-potential nascent projects, we find support for the hypothesis that balanced skills are an important factor for making progress in the venture creation process. Interestingly, none of the traditional human capital indicators such as prior managerial and entrepreneurial experience predict the progress of the project. However, they contribute to a balanced skill set, supporting the investment hypothesis on balanced skill origins. We also find empirical evidence for the endowment hypothesis suggesting that a balanced skill set is deeply rooted in the adolescent development and personality characteristics of the nascent entrepreneurs.
Innovazione nel patrimonio dei fari italiani. Un progetto di conservazione e uso sostenibile per la “luce” sarda di Capo Spartivento
Innovation in italian lighthouses heritage. A conservation and sustainable use project for the sardinian light of Capo Spartivento
Creators: name: Bartolomei, Cristiana; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR14 - Composizione architettonica e urbana
fari; progetto; sostenibilità;
ICAR14 - Architectural and urban design
lighthouses; design; sustainability;

description: L’articolo vuole documentare la riqualificazione del faro di CapoSpartivento in Sardegna che da area militare diventa un hotel di lusso a cinque stelle, da parte dello Studio dal Molin di Cagliari.L’obiettivo prioritario è stato risanare, riqualificare (anche con l’uso della tecnologia eccocompatibile) e ridisegnare la distribuzione degli interni e degli esterni, nel totale rispetto della tradizione mediterranea, conservarvandone il fascino classico di un faro mediterraneo che compie più di 142 anni, intervenendo con discrezione e stile, nella distribuzione interna ed esterna, sui materiali e sugli arredi. La rifunzionalizzazione del faro appare più che gradevole, confortevole, tecnologica, ecocompatibile e mediterraneo, capace di far dialogare passato e presente, perfettamente integrata con l’esterno.
description: Rehabilitating a lighthouse, within the italian scenario, it’s a really complex challenge.Many of the active italian lighthouses (estimated in 160 lights) are at risk of decay; it’s an ancient heritage where many lights were built more than 150 years ago. The Italian Navy is appointing adaptive re-use of buildings and conservation projects.Capo Spartivento lighthouse, built in 1866 and located in the southern point of Sardinia, can be considered as an exemplar project. At the end of the (restoration) works the lighthouse looks more comfortable, technological, eco- friendly and Mediterranean, in a perfect fit with the surrounding environment. The lighthouse can be seen as a best practice project in terms of architectural tuning and sustainanle materials, energy saving and power production by way of renewables and sustainable design technologies.
Phase selection in the mushy-zone: LODESTARS and ELFSTONE projects
Creators: name: Matson, D M
name: Hyers, R W
name: Volkmann, T
name: Fecht, H -J
Publisher: name: Universität Ulm
Year: 2011
Subjects: subject: alloy phase selection
subject: kinetics
subject: DDC 530 / Physics
subject: Convection (Astrophysics)
subject: Dynamics
subject: Konvektion

description: In a collaboration sponsored by ESA and NASA, international partners have developed a work plan to successfully address key issues relating to understanding the role of convection on alloy phase selection for commercially important structural alloys using the MSL-EML facility aboard the International Space Station. The approach is two-pronged. First, ground and space-based experiments will develop a baseline database to anchor subsequent modelling predictions. Tasks include sample preparation and verification, ground-based transformation evaluation, space-based experiments, and thermophysical property evaluation to support modelling activities. Second, modelling and theoretical analysis tasks will lead to a new understanding of the role of convection in phase selection for this class of materials. These models will allow prediction and control of microstructural evolution during solidification processing. Tasks include modelling of macroconvection induced by the EM levitation field, modelling of microconvection within the dendrite array, nucleation modelling, and modelling of the transformation kinetics specific to each alloy system. This paper outlines how two NASA-sponsored projects relate to the goals of the international collaboration.
Predicting the Sensitivity of Avian Species to the Embryotoxic Effects of Polychlorinated Biphenyls (PCBs) Using 'in vitro' Approaches
Creators: name: Manning, Gillian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012

description: The goal of this thesis was to use a luciferase reporter gene (LRG) assay in order to predict avian species sensitivity to the toxic effects of polychlorinated biphenyl (PCB) congeners 126, 77, 105 and 118 based on their aryl hydrocarbon receptor 1 (AHR1) ligand binding domain (LBD) sequence. These results were then compared to ethoxyresorufin O-deethylase (EROD) activity and CYP1A4/5 mRNA expression measured in three model species. The amino acid residues at positions 324 and 380 in the AHR1 LBD are the major determinants of avian species sensitivity to PCBs. Both LRG and EROD activity were significantly correlated with embryolethality and were better predictors of PCB-induced embryolethality than CYP1A4/5 mRNA expression. These results support the hypothesis that the LRG assay in combination with a species’ AHR1 LBD sequence can be used to predict PCB-induced embryolethality in potentially any avian species of interest without the use of lethal methods.
Ex Sta.Ve.Co.: un laboratorio permanente di ricerca
Ex Sta.Ve.Co.: an on-going research laboratory
Creators: name: Evangelisti, Francesco; Comune Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR21 - Urbanistica
riqualificazione urbana; recupero aree militari dismesse; pianificazione urbanistica; disegno urbano;
ICAR21 - Urbanism and urban design
urban regeneration; abandoned military areas; urban planning, urban design;

description: Il destino dell’area oggi conosciuta come “ex Sta.Ve.Co” è un tema quasi “classico” per gli studenti di architettura e ingegneria, ormai da più generazioni, forse proprio da quando si pensò che l’area avrebbe potuto essere ristrutturata per ospitare la sede della Facoltà nata da poco, negli anni ‘30.In più di cinquant’anni lo studio dell’area ha sviluppato numerose proposte, progetti e modalità di reintegrazione all’uso urbano, riconoscendone la posizione strategica, in particolare per il rapporto che può garantire tra centro storico e collina. Proprio su quest’ultimo tema si concentra il Piano strutturale del Comune di Bologna, a seguito della dismissione dell’area e della volontà, da parte dello Stato, di valorizzarla trasformandola ad altri usi.
description: The fate of the area nowadays known as “ex Sta.Ve.Co” is an almost “classic” theme for students of Architecture and Engineering, for several generations now, perhaps since it was supposed that the area could be renovated to house the headquarters of the newly born Faculty, in the Thirties.In more than fifty years studies concerning the area has developed numerous proposals, plans and procedures for urban revitalization, recognizing its strategic position, particularly if related to the historic city and to the hill. On this last theme the structural plan of the Municipality of Bologna developed a strategy, following the disposal of the area and the willingness of the Italian government to highlight it, with new functions ad urban uses.
Supplementary document for Efficient scattering model of multi-layer systems with anisotropic films - 5157383.pdf
Creators: name: Gill, Jordan
name: Perivolari, Elena
name: Kaczmarek, Malgosia
name: Alessandro, Giampaolo D
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental document.
TEMPORARY OUTLET CENTER. Riuso e rivitalizzazione di aree dismesse attraverso il commercio itinerante
TEMPORARY OUTLET CENTER. Disused areas renovation through nomadic commerce
Creators: name: Gaiti, Gabriele; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR14 - Composizione architettonica e urbana
Architettura temporanea; Factory Outlet Center; Rigenerazione Urbana; ETFE;
ICAR14 - Architectural and urban design
Temporary Architecture; Factory Outlet Center; Urban renovation; ETFE;

description: I luoghi dello shopping e del consumo sono diventati, in modo sempre più evidente, i nuovi luoghi pubblici di attrazione della città contemporanea. Com’è possibile sfruttare il potere attrattivo del commercio senza generare ulteriore consumo di suolo?Il Temporary Outlet Center (TOC) cerca di conciliare queste due istanze, apparentemente così lontane tra loro, mediante lo sviluppo dei concetti di temporaneità e mobilità.Il progetto prevede un intervento a “cubatura zero” basato su strutture leggere interamente smontabili e aggregabili tra loro in infinite soluzioni, che non costruisca nulla di fisso ad eccezione delle urbanizzazioni primarie. L’esperienza dello shopping potrà quindi fungere da attivatore urbano per aree dismesse da riqualificare all’interno del tessuto urbano o aree degradate da rivitalizzare.
description: Shopping and consumption places have ever more noticeably become new public attraction places of the present-day city.  How is it possible to capitalize on the lure of trade without generating further soil usage?Temporary Outlet Center (TOC) tries to conciliate these two requests, seemingly so far away from each other, through the development of temporariness and mobility concepts. This project consist in a “zero cubic capacity” building work based on wholly dismountable light structures, aggregable in endless solutions, which does not construct nothing of immobile with the exception of primary urbanizations.Therefore shopping experience could act as urban activator for both disused areas to be renewed within urban fabric and degraded areas to be revitalized.
Anforderungen der Integration der erneuerbaren Energien an die Netzentgeltregulierung
Creators: name: Friedrichsen, Nele
name: Hilpert, Johannes
name: Klobasa, Marian
Publisher: name: My University
Year: 2016
Subjects: subject: Netzentgeltregulierung
subject: Netzentgeltsystem
subject: Erneuerbare Energie
subject: Klima | Energie

description: Die Studie zeigt wie das Netzentgelt- und Netznutzungssystem weiterentwickelt werden sollte, um passfähig für eine zukünftig von erneuerbaren Energien dominierte Stromversorgung zu sein. Dazu werden konkrete Handlungsempfehlungen erarbeitet: eine Reform der Ausnahmeregelungen für die Industrie, die Einführung bundesweit einheitlicher Übertragungsnetzentgelte in Verbindung mit einer Modifikation der vermiedenen Netznutzungsentgelte, die Erhöhung des Grundpreises in der Niederspannung, die Beteiligung von Eigenerzeugern /-verbrauchern und Einspeisern an den Netzkosten, sowie langfristig variable Netzentgelte für Stromspeicher und sonstige Flexibilitätsoptionen. Quelle: Umweltbundesamt
description: Die Studie zeigt wie das Netzentgelt- und Netznutzungssystem weiterentwickelt werden sollte, um passfähig für eine zukünftig von erneuerbaren Energien dominierte Stromversorgung zu sein. Dazu werden konkrete Handlungsempfehlungen erarbeitet: eine Reform der Ausnahmeregelungen für die Industrie, die Einführung bundesweit einheitlicher Übertragungsnetzentgelte in Verbindung mit einer Modifikation der vermiedenen Netznutzungsentgelte, die Erhöhung des Grundpreises in der Niederspannung, die Beteiligung von Eigenerzeugern /-verbrauchern und Einspeisern an den Netzkosten, sowie langfristig variable Netzentgelte für Stromspeicher und sonstige Flexibilitätsoptionen.
Additional file 3 of Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Creators: name: Mateo, Lidia
name: Duran-Frigola, Miquel
name: Gris-Oliver, Albert
name: Palafox, Marta
name: Scaltriti, Maurizio
name: Pedram Razavi
name: Sarat Chandarlapaty
name: Joaquin Arribas
name: Meritxell Bellet
name: Serra, Violeta
name: Aloy, Patrick
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 3. This pdf file contains the Supplementary Figures that are referenced throughout the manuscript, together with their figure legends. Higher resolution figures and extended data are available upon reasonable request.
Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
Creators: name: Maxwell, Lara J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: ankylosing spondylitis
anti-TNF therapy
systematic review
longitudinal analysis
variability

description: Ankylosing spondylitis (AS) is a chronic, inflammatory rheumatic disease that has a highly variable disease course. Three biologic agents, adalimumab, etanercept, and infliximab, have been developed for the treatment of AS. We conducted three studies: 1) an exploratory analysis of a year-long longitudinal dataset to gain insight into the variability of disease activity, physical function, and well-being and to explore the relationship between these outcome measures; 2) a systematic review of the available evidence for the efficacy of biologic treatment; 3) a systematic review of potential adverse effects of this treatment. We found that repeated measures of disease activity, function and well-being fluctuate considerably between patients, with complex patterns occurring over time within patients. There was mostly high quality evidence that these biologics are efficacious against placebo. We did not find evidence of an increase in serious adverse events or serious infections from short-term randomized controlled trials.
title: Der Weg zur treibhausgasneutralen Verwaltung
title: Der Weg zur treibhausgasneutralen Verwaltung
titleType: AlternativeTitle
Creators: name: Huckestein, Burkhard
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Klimaschutz
subject: Verwaltung
subject: Umweltmanagement
subject: Treibhausgasbilanz
subject: Treibhausgasemissionen
subject: Treibhausgasbilanzierung
subject: Vorbildfunktion
subject: Nachhaltigkeit | Strategien | Internationales

description: Ein neuer Leitfaden des UBA unterstützt Verwaltungen dabei, ihre Vorbildfunktion im Klimaschutz zu verbessern. Hierzu stellt er die Etappen auf dem Weg zur treibhausgasneutralen Verwaltung dar, beschreibt die hierzu notwendigen Schritte und gibt praktische Empfehlungen für die dabei auftretenden Herausforderungen. Zu den wichtigsten Themen und Handlungsfeldern enthält er umfangreiche weiterführende Informationen, praxisrelevante Hilfestellungen und Checklisten. Der Leitfaden richtet sich vorrangig an öffentliche Einrichtungen, die mehr für den Klimaschutz tun möchten. Darüber hinaus gibt er auch Unternehmen eine Orientierung, wie sie glaubwürdig treibhausgasneutral werden können. Quelle: www.umweltbundesamt.de
description: Ein neuer Leitfaden des ⁠UBA⁠ unterstützt Verwaltungen dabei, ihre Vorbildfunktion im ⁠Klimaschutz⁠ zu verbessern. Hierzu stellt er die Etappen auf dem Weg zur treibhausgasneutralen Verwaltung dar, beschreibt die hierzu notwendigen Schritte und gibt praktische Empfehlungen für die dabei auftretenden Herausforderungen. Zu den wichtigsten Themen und Handlungsfeldern enthält er umfangreiche weiterführende Informationen, praxisrelevante Hilfestellungen und Checklisten. Der Leitfaden richtet sich vorrangig an öffentliche Einrichtungen, die mehr für den Klimaschutz tun möchten. Darüber hinaus gibt er auch Unternehmen eine Orientierung, wie sie glaubwürdig treibhausgasneutral werden können.
Supplementary document for Single-objective high-resolution light sheet fluorescence microscopy for standard biological sample geometries - 5157643.pdf
Creators: name: Drescher, Knut
name: Yordanov, Stoyan
name: Neuhaus, Konstantin
name: Hartmann, Raimo
name: Diaz-Pascual, Francisco
name: Vidakovic, Lucia
name: Singh, Praveen
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Methods
City-making. Chances of urban regeneration
City-making. Occasioni di rigenerazione urbana
Creators: name: Bravo, Luisa; Università Di Bologna
name: Ciampolini, Francesco; Università Di Bologna
name: Francia, Valerio; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR21 - Urbanism and urban design
city-making; urban regeneration; Sta.Ve.Co
ICAR21 - Urbanistica
city-making; rigenerazione urbana; Sta.Ve.Co;

description: Urban transformation resulting from the reutilization of urban areas located close to historical consolidated areas, formerly occupied by industrial complexes, settled at the end of the nineteenth century (and now abandoned) and by disued military areas, represent a great opportunity for regeneration and urban renewal, in order to balance the physical and functional structure of the existing city. Mostly there areas are real voids to be returned to the city, assigning new functions, catalyst of differente activities and generatior of a substantial housing income, and defining new spaces, both for public and private use, aimed at combining social and collective urban interaction.
description: Le trasformazioni urbane derivanti dalla rifunzionalizzazione delle aree poste a ridosso degli ambiti storici consolidati, lasciate libere dai complessi industriali, insediati alla fine dell’Ottocento (e oggi dismessi) e dalle aree militari in disuso, rappresentano un’occasione di forte rigenerazione e riqualificazione urbana attraverso le quali riequilibrare gli assetti fisici e funzionali della città esistente. Si tratta per lo più di veri e propri vuoti da restituire alla città, assegnando nuove funzioni, catalizzatrici di attività e generatrici di una consistente rendita immobiliare, e definendo nuovi spazi, di uso sia pubblico che privato, rivolti alla socialità e all’aggregazione collettiva.
Ethics monitoring. Second release.
Creators: name: SERRANO, LEIRE
name: Dziabenko, Olga
name: Sasia, Pedro Manuel
Publisher: name: Zenodo
Year: 2024
Subjects: subject: GDPR
subject: ethical aspects
subject: informed consent form
subject: data management
subject: Data processing
subject: personal data

description: Adherence to ethical principles and regulations was crucial for the TANGENT successful implementation. This deliverable outlines the updated procedures for conducting research and exploitation in compliance with EU and national ethical standards. We have revised the informed consent templates that must be completed by individuals participating in project activities, workshops, the TANGENT Forum, and traveler behavior modeling. This deliverable also introduces updated measures for effective data management throughout the project, including the handling of personal data. The project implemented various mechanisms for effective data management and protection, as outlined in the Deliverable D9.8. Based on the GDPR privacy policy (Articles 12, 13, and 14) the TANGENT dashboard privacy policy was created and published.Therefore, the deliverable presented the updated version of the D9.4 submitted in month 12.
Organ allocation and patient responsibility: Re-examining the concept of responsibility in light of the thought of Emmanuel Levinas.
Creators: name: Burbidge, Nancy M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Philosophy.

description: A persisting, unresolved debate in the bioethics literature was the impetus behind this work. The focus chosen was the need for replacement organs for those whose illnesses appear to be related to addiction to alcohol or tobacco. The initial section thus examines the more factual aspects of both addiction and organ transplantation. The history of organ transplantation is explored, focusing particularly on the attempts to frame criteria for reception of the scarce organs, and the concomitant attempts to increase the supply of donated organs; neither issue has been solved, although there is much research being focused on technical solutions in particular, for those awaiting scarce organs. Within the bioethics literature, the issue of criteria for the reception of scarce organs has tended to be viewed as a question of justice. Thus this work peruses the varying conceptions of justice which appear within that literature, in an attempt to ascertain whether their applications have involved differing results for the population in question. In fact, there appears to be little difference in the outcomes amongst those ascribing to one or other of the meta-ethical theories. In contrast to the extensive treatment of issues of justice within bioethics, the concept of responsibility is largely unexamined. This dearth suggested that an historical perusal of the concept of responsibility within a number of the disciplines to which bioethics turns would be appropriate. In the end, the thought of Emmanuel Levinas appeared to offer the most fruitful approach to the topic under consideration. His work appears to be a profound challenge to rethink our relationships to others, as well as our approach to justice. Central to that thought is what Levinas calls the relationship of the one-for-the-other; the philosopher suggests that a response of profound responsibility for the other before one is called forth by the visage of that "wounded" other. The question of justice does arise for Levinas, since in the eyes of the other before one are all the others; thus needs must be weighed and choices made. The benchmark for this justice, however, is the relationship of the one-for-the-other: real justice implies, not a faceless, objectified totality, but an attention to the needs of all---the very antithesis of the utilitarian approach so prevalent within much of North American bioethics. (Abstract shortened by UMI.)
MPEC 2024-N137 : 2023 WL2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Supplementary document for Single-objective high-resolution light sheet fluorescence microscopy for standard biological sample geometries - 5157643.pdf
Creators: name: Drescher, Knut
name: Yordanov, Stoyan
name: Neuhaus, Konstantin
name: Hartmann, Raimo
name: Diaz-Pascual, Francisco
name: Vidakovic, Lucia
name: Singh, Praveen
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental Methods
ArcGIS basierte Lösung zur detaillierten, deutschlandweiten Verteilung (Gridding) nationaler Emissionsjahreswerte auf Basis des Inventars zur Emissionsberichterstattung
Creators: name: Schneider, Christiane
name: Pelzer, Michael
name: Toenges-Schuller, Nicola
Publisher: name: My University
Year: 2016
Subjects: subject: Emissionsbericht
subject: Luftreinhaltung
subject: ArcGIS
subject: gridding
subject: Emissionsjahreswerte
subject: Emissionsberichterstattung
subject: Luftschadstoffe
subject: Luft

description: Informationen zur räumlichen Verteilung von Emissionen sind für eine Vielzahl von Fragestellungen im Bereich der Luftreinhaltung von großer Bedeutung, z.B. im Rahmen der Erfüllung von internationalen Berichtspflichten, der Bereitstellung von Eingangsdaten für Ausbreitungsmodellierungen von Luftschadstoffen oder zur Visualisierung der räumlichen Verteilungsstruktur der Emissionen.Existierende Inventare beim ⁠UBA⁠ enthalten diese räumlichen Informationen entweder nicht (Emissionsinventar zur Emissionsberichterstattung differenziert nach NFR-Sektoren) oder bilden nur einen Teil der gesamten Emissionen ab (⁠PRTR⁠). Daher wurde eine ESRI ArcGIS-basierte Software entwickelt, die es dem UBA erlaubt, eigenständig und auf der Grundlage allgemein verfügbarer Informationen regelmäßig räumlich hoch aufgelöste Emissionsdatensätze zu generieren, d.h. eine flächenhafte Zuordnung der nur national verfügbaren quellgruppenspezifischen Emissionsdaten (nationale Jahreswerte) auf die gesamte Fläche der Bundesrepublik vorzunehmen.Die Software („Gridding-Tool“) wurde dem UBA zur Verfügung gestellt, so dass dort selbstständig Berechnungen und auch Modifikationen durchgeführt werden können. Die Software ist detailliert dokumentiert und erfüllt hohe Anforderungen an Flexibilität und Erweiterbarkeit.
StavecoLab. Works by students attending Architectural Design Course in Bologna
StavecoLab. Il contributo degli studenti in Composizione Architettonica di Bologna
Creators: name: Luccaroni, Andrea; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2011
Subjects: ICAR14 - Architectural and urban design
Sta.Ve.Co; exclusion; hills; urban transformation; industrial conversion;
ICAR14 - Composizione architettonica e urbana
Sta.Ve.Co; collina; rigenerazione urbana; esclusione; riconversione industriale;

description: In these pages the design work developed in 2011 by students of Architectural Design of the University of Bologna is documented, which was discussed and compared with the canadian students at Carleton University, Ottawa, on the former military industrial area named Staveco, in Bologna.Beyond strategies set to recover the relationship with the hill through a process of urban transformation, the interest lies in the condition of otherness and isolation of the area, adjacent to the historic center but never really involved in the life of the city. This hidden and inaccessible area will become a vehicle of connection between different territories. It is argued here as a contradictory condition could be an element of strength, provided a courageous way of interpreting the opportunities and dealing decisively with the crucial issues. The students’ projects illustrate the topic.
description: In queste pagine viene descritto il lavoro progettuale svolto nel 2011 dagli studenti di Bologna in Architettura e Composizione Architettonica 3, oggetto di confronto con gli allievi canadesi della Carleton University, sull’area industriale militare ex StaVeCo.Al di là delle strategie per recuperare il rapporto con la collina attraverso un processo di trasformazione urbana, l’interesse risiede nella condizione di alterità ed isolamento dell’area, adiacente al centro storico, eppure mai realmente coinvolta nella vita della città. Un’area nascosta e inaccessibile diverrà veicolo di connessone fra territori.Si sostiene qui come una condizione contraddittoria possa costituire elemento di forza, a patto di interpretarne in modo coraggioso le opportunità ed affrontare con decisione le questioni cruciali. I proStavecoLab.Works by students attending Architectural Design Course in Bolognagetti degli studenti illustrano l’argomento.
An in vivo approach to the study of apolipoprotein A-I structure-function relationships.
Creators: name: McManus, Daniel Charles.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Chemistry, Biochemistry.

description: Apolipoprotein A-I (apoA-I) is a non-glycosylated 243 amino acid (aa) circulating plasma protein and the major constituent of high density lipoproteins (HDL). To study apoA-I in a physiologically relevant in vivo model, recombinant adenoviruses carrying cDNAs encoding for native human apoA-I (hapoA-I) and different apoA-I mutations were created. This is the first reported use of recombinant adenoviruses to study structure-function relationships of human apoA-I. In the first study, two functional domains within the central region of the protein (aa 100--186) were identified. The results establish that helix 6 (aa 144--165) is primarily responsible for activation of the enzyme lecithin:cholesterol acyltransferase (LCAT) while the more N-terminal half of the central domain, specifically the class Y helix 4 (aa 100--121), is important for lipid binding and/or stabilizing apoA-I on the surface of lipoproteins. A recombinant adenovirus was also produced encoding for a naturally occurring apoA-I point mutation with a Leu → Arg substitution at as 159. This apoA-I variant, known as apoA-I Finland (apoA-IFIN), causes an unexpected 80% reduction in HDL cholesterol (HDL-C) and apoA-I concentrations in heterozygous carriers. A combined in vitro, in vivo and ex vivo study demonstrated that this mutant has impaired activation of LCAT, is susceptible to proteolysis and has a decreased rate of secretion from primary hepatocytes. These dysfunctions appear to be responsible for the dominantly inherited hypoalphalipoproteinemia in heterozygous carriers of the apoA-I FIN mutation. Lastly, secretion of nascent HDL was monitored from primary hepatocytes. The recombinant adenovirus expressing hapoA-I was used to infect apoA-I deficient murine hepatocytes. In contrast to some previous studies, a significant pool of apoA-I was secreted with phospholipids (PL) and was heterogeneous in size. The role of this nascent HDL pool in determining plasma HDL-C concentrations is not known nor is the importance of other proteins in this process. The recent discovery of a major role for ATP binding cassette transporter A1 (ABCA1) in phospholipid (PL) and cholesterol efflux to apoA-I has led to the speculation that this protein may also shuttle lipids onto newly secreted apoA-I. The model described here will be useful to address this possibility.
Additional file 4 of High sensitivity of one-step real-time reverse transcription quantitative PCR to detect low virus titers in large mosquito pools
Creators: name: Zhaoyang Tang
name: Hanano Yamada
name: Kraupa, Carina
name: Sumejja Canic
name: Busquets, Núria
name: Talavera, Sandra
name: Jiolle, Davy
name: Vreysen, Marc J. B.
name: Bouyer, Jérémy
name: Abd-Alla, Adly M. M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 4: Table S3. Determination the viral copy number in infected mosquito bodies used to spike mosquito pools.
Establishing a Japanese transplant company in the Indian automobile industry: a qualitative study of cultural disrespect
Creators: name: Kunju Kunju Mathew, Sagi
Publisher: name: Swinburne
Year: 2024

description: This thesis analyses the operations of Toyota Kirloskar Motors (TMK) in India during the period 1997-2010. TKM is the Indian arm of Toyota’s production operations in India formed as a result of a joint venture between the company and the Kirloskar group of companies in India. Whereas Toyota has generally enjoyed harmonious industrial relations within its transplanted companies around the world it has experienced severe industrial unrest in India and has failed to achieve its ambitious production and market share forecasts in the country. Accordingly, this thesis sets out to answer the research question 'why has TKM experienced such a tumultuous journey since its establishment in 1999?' The thesis employs a qualitative methodology using the technique of conceptual ordering. Data has been obtained from personal interviews, document analysis, and observation. Several trips were undertaken to India to gather data. The thesis argues that disrespect shown towards traditional Indian cultural and social practices underlies the explanation for the industrial unrest during the period until 2006. During this period various types of disrespect have been identified as occurring in a continuous flow and overlaying each other in a sedimentary-type manner. This dynamic sedimentation of disrespect over a longitudinal time period was reacted to by various forms of retaliation from TKM workers creating a cause-consequence cycle of detrimental actions. It is also argued that TKM misunderstood the nature of protest in India and over-reacted to worker unrest on several occasions. This scenario changed drastically from 2007 when TKM introduced a new policy of reconciliation aimed at changing perceptions within the company. This attempt to salvage respect included a range of actions aimed at removing the causes of the ongoing unrest and which by their nature were directed at ensuring more respectful relationships within the plant. The research has implications for the manner in which multinational companies conduct their operations in host countries, especially when a pervasive alien corporate culture is introduced into a host nation with strong social and cultural sensitivities.