title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÐ¸Ð·Ð¸ÐºÐ¾-Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð½Ð° Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ Ð¼Ð°ÑÑÐ¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð° Ð¸ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» Ñ Ð¸ÑÐ¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: The influence of physicochemical properties on the biocompatibility of matrices based on chitosan and chitin nanofibrils
Creators: name: ÐÐ¾Ð»Ð±Ðµ, ÐÐ¾Ð½ÑÑÐ°Ð½ÑÐ¸Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ñ Ð¸ÑÐ¾Ð·Ð°Ð½
Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð»Ñ Ñ Ð¸ÑÐ¸Ð½Ð°
ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»
ÑÐºÐ°Ð½ÐµÐ²Ð°Ñ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ
Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°
ÑÐ»ÐµÐºÑÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð´Ð½Ð¾ÑÑÑ
ÐºÐ¾Ð½ÑÐ°ÐºÑÐ½ÑÐ¹ ÑÐ³Ð¾Ð»
Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ
ÑÐ¸Ð±ÑÐ¾Ð±Ð»Ð°ÑÑÑ
Ð´Ð·ÐµÑÐ°-Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»
chitosan
chitin nanofibers
composite material
tissue engeneering
mechanical propeties
electrical conductance
contact angle
biocompatibility
fibroblastes
zeta potential

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description: The aim of this work is to obtain film composite materials based on chitosan with the introduction of chitin nanofibrils, which have the necessary properties for use in technologies of tissue engineering. The work was fulfilled in the laboratory "Polymer materials for tissue engineering and transplantology" Peter the Great SPbPU. Taking into account the choice of chemical raw materials, composite materials based on chitosan with the addition of a filler of chitin nanofibrils were obtained. A significant part of the experiments to study the properties of the obtained samples was carried out using available specialized equipment. The uniaxial tension method was used to study the mechanical properties of materials. The contact angle was determined using the sessile drop method. The dependence of electrical conductivity on the concentration of chitin in a composite film was studied. Surface properties of materials were assessed by the zeta potential. Differences in the biocompatibility and bioactivity of the matrices were shown with respect to the culture of human dermal fibroblasts using the MTT test and light microscopy. The mechanical properties and electrical conductivity of the matrices were compared with their bioactivity for chitosan based matrices with the addition of 5 wt.% chitin nanofibrils in the composite.