cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Comment accompagner les parents ayant un enfant en fin de vie en milieu hospitalier ?
title: une esquisse de bonnes pratiques dans le cadre d’un accompagnement optimal
titleType: Subtitle
Creators: name: Alves Furtado, Liliana
name: Benz, Hélène
name: Sunier, Caryn
Publisher: name: Unknown
Year: 0
Subjects: subject: rôle infirmier
subject: attachement
subject: relation soignant-famille
subject: relation parents-enfants
subject: enfant
subject: fin de vie
subject: hôpital

description: Avoir un enfant atteint d’une maladie grave, qui se trouve potentiellement face à la mort, est une expérience particulièrement difficile à vivre pour les parents. Il s’agit d’un sujet bouleversant, sensible, singulier et complexe à la fois. En effet, l’expérience que vivent les parents ayant un enfant en fin de vie est une grande source d’anxiété et de stress. Le sujet est d’un intérêt majeur à nos yeux, car en tant que soignants, comment arriverons-nous à surmonter nos émotions afin d’établir une relation d’aide optimale ?
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome.
Creators: name: Prakash, L
name: Petes, T D
name: Henderson, S T
name: Johnson, R E
name: Bankmann, M
name: Prakash, S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: rad5 (rev2) mutants of Saccharomyces cerevisiae are sensitive to UV light and other DNA-damaging agents, and RAD5 is in the RAD6 epistasis group of DNA repair genes. To unambiguously define the function of RAD5, we have cloned the RAD5 gene, determined the effects of the rad5 deletion mutation on DNA repair, DNA damage-induced mutagenesis, and other cellular processes, and analyzed the sequence of RAD5-encoded protein. Our genetic studies indicate that RAD5 functions primarily with RAD18 in error-free postreplication repair. We also show that RAD5 affects the rate of instability of poly(GT) repeat sequences. Genomic poly(GT) sequences normally change length at a rate of about 10(-4); this rate is approximately 10-fold lower in the rad5 deletion mutant than in the corresponding isogenic wild-type strain. RAD5 encodes a protein of 1,169 amino acids of M(r) 134,000, and it contains several interesting sequence motifs. All seven conserved domains found associated with DNA helicases are present in RAD5. RAD5 also contains a cysteine-rich sequence motif that resembles the corresponding sequences found in 11 other proteins, including those encoded by the DNA repair gene RAD18 and the RAG1 gene required for immunoglobin gene arrangement. A leucine zipper motif preceded by a basic region is also present in RAD5. The cysteine-rich region may coordinate the binding of zinc; this region and the basic segment might constitute distinct DNA-binding domains in RAD5. Possible roles of RAD5 putative ATPase/DNA helicase activity in DNA repair and in the maintenance of wild-type rates of instability of simple repetitive sequences are discussed.
title: La violence en psychiatrie
title: quelles stratégies ou quels moyens de prévention et de gestion de la violence peuvent amener un impact bénéfique tant pour la pratique clinique infirmière que pour le bien-être du patient ?
titleType: Subtitle
Creators: name: Badel, Sophie
name: Iseppon, Hélène
Publisher: name: Unknown
Year: 0
Subjects: subject: rôle infirmier
subject: prévention
subject: violence
subject: psychiatrie
subject: santé mentale

description: Notre revue de littérature traite du sujet de la violence en psychiatrie. En effet, la violence est une préoccupation qui a toute son importance dans les soins d’autant plus que c’est une problématique fréquemment rencontrée dans les unités de santé mentale. Cette revue de littérature a pour but de nous aider à comprendre la façon dont on peut gérer et prévenir la violence en psychiatrie afin d’améliorer notre rôle infirmier et ainsi tendre vers une meilleure prise en charge. Les principaux résultats obtenus relèvent l’importance de la formation continue quant à la prévention et à la gestion de la violence. En effet, diverses méthodes sont explicitées et démontrent la nécessité d’une telle intervention. De plus, il apparaît essentiel de connaître les facteurs causaux d’incidents agressifs afin de pouvoir mieux les prévenir et les gérer. Un point notable ressort également des différents résultats. La contention et l’isolement sont parfois utilisés de manière inadéquate, c’est-à-dire sans aucune explication au patient et en réponse à la violence ou à un comportement agressif afin d’y mettre un terme. Il est nécessaire de considérer les protocoles concernant l’utilisation des mesures de contraintes et de poursuivre les recherches dans ce sens-là. De ces divers résultats de notre revue de littérature émergent des habiletés relationnelles dont l’importance n’est plus à prouver : les compétences en communication, l’approche empathique et la collaboration soignant-soigné sont indispensables dans la prise en soins.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
A Novel (k,n) Secret Sharing Scheme from Quadratic Residues for Grayscale Images
Creators: name: Abdelsatir, El-Tigani B.
name: Salahaldeen, Sahar
name: Omar, Hyam
name: Hashim, Afra
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: A new grayscale image encryption algorithm based on $(k,n)$ threshold secret sharing is proposed. The scheme allows a secret image to be transformed into $n$ shares, where any $k \le n$ shares can be used to reconstruct the secret image, while the knowledge of $k-1$ or fewer shares leaves no sufficient information about the secret image and it becomes hard to decrypt the transmitted image. In the proposed scheme, the pixels of the secret image are first permuted and then encrypted by using quadratic residues. In the final stage, the encrypted image is shared into n shadow images using polynomials of Shamir scheme. The proposed scheme is provably secure and the experimental results shows that the scheme performs well while maintaining high levels of quality in the reconstructed image.
Interaction of Shock Train with Cavity Shear Layer in a Scramjet Isolator
Creators: name: Sethuraman, Vignesh Ram Petha
name: Yang, Yosheph
name: Kim, Jae Gang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The interaction between the self-excited shock train flow and the cavity shear layer in a scramjet isolator is investigated numerically using detached-eddy simulations (DES). The effect of changing the position of the shock train by controlling the back pressure ratio and the effect of changing the cavity front wall angle are analyzed using unsteady statistics and modal analysis. The propagation mechanism of the pressure disturbance was investigated by spatiotemporal cross-correlation coefficient analysis. In the present numerical study, a constant isolator section with a cavity front wall was considered, followed by a diffuser section simulated at Mach number 2.2 with three different back pressure ratios. The change in back pressure provides three different conditions. To understand the unsteady dynamics of the interaction of the shear layer with the shock train, the spatiotemporal trajectory of the wall pressure and the centerline pressure distribution, the spatiotemporal cross-correlation coefficient, and the modal analysis by dynamic mode decomposition are obtained. The results show that the low-frequency shock train oscillation dominates the cavity oscillation. The spatiotemporal cross-correlation between the wall surface and the cavity bottom wall indicates the propagation of local disturbances originating from the separated boundary layer caused by the shock and the recirculation zone in the corners of the cavity. Dynamic mode decomposition analysis shows the shear layer at the leading edge of the cavity and the downstream propagation of large eddies from the cavity. It also shows the pairing of coherent structures between the shock train and the recirculation zone of the cavity.
description: Submitted to Physics of Fluid
Heavy ion beam loss mechanisms at an electron-ion collider
Creators: name: Klein, Spencer R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: There are currently several proposals to build a high-luminosity electron-ion collider, to study the spin structure of matter and measure parton densities in heavy nuclei, and to search for gluon saturation and new phenomena like the colored glass condensate. These measurements require operation with heavy-nuclei. We calculate the cross-sections for two important processes that will affect accelerator and detector operations: bound-free pair production, and Coulomb excitation of the nuclei. Both of these reactions have large cross-sections, 28-56 mb, which can lead to beam ion losses, produce beams of particles with altered charge:mass ratio, and produce a large flux of neutrons in zero degree calorimeters. The loss of beam particles limits the sustainable electron-ion luminosity to levels of several times $10^{32}/$cm$^2$/s.
description: 4 pages with 1 figure
Quels sont les impacts de la mucoviscidose, en tant qu'atteinte chronique, sur la fratrie saine d'un enfant malade ?
Creators: name: Caboussat Mouny, Barbara
Publisher: name: Unknown
Year: 0
Subjects: subject: pédiatrie
subject: enfant
subject: maladie chronique
subject: mucoviscidose
subject: relations frères-soeurs
subject: relations patient-famille

description: Cette revue de littérature, réalisée dans le cadre de ma formation en soins infirmiers, porte sur la fratrie saine d'enfants atteints de mucoviscidose et plus précisément sur les impacts vécus par les frères et sœurs. La source de mon questionnement est principalement la réalisation d'un stage en pédiatrie et les interrogations qui sont nées dans mon esprit à ce moment-là. Par ailleurs, la lecture de divers articles a exacerbé ces interrogations et m'ont permis d'affiner mon choix en matière de problématique. Etant, et depuis toujours, fortement attirée par la pédiatrie et considérant que la cellule familiale doit être au centre de la prise en soins, j'ai choisi d'utiliser le modèle de McGill qui met principalement l'accent sur les interactions entre les différents membres de la famille. Compte tenu de ces divers éléments, mon questionnement est formulé de la manière suivante: Quels sont les impacts positifs et négatifs de la mucoviscidose, en tant qu’atteinte chronique, sur la fratrie saine d’un enfant malade ?
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
Microwave-engineering of programmable XXZ Hamiltonians in arrays of Rydberg atoms
Creators: name: Scholl, P.
name: Williams, H. J.
name: Bornet, G.
name: Wallner, F.
name: Barredo, D.
name: Lahaye, T.
name: Browaeys, A.
name: Henriet, L.
name: Signoles, A.
name: Hainaut, C.
name: Franz, T.
name: Geier, S.
name: Tebben, A.
name: Salzinger, A.
name: Zürn, G.
name: Weidemüller, M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We use the resonant dipole-dipole interaction between Rydberg atoms and a periodic external microwave field to engineer XXZ spin Hamiltonians with tunable anisotropies. The atoms are placed in 1D and 2D arrays of optical tweezers, allowing us to study iconic situations in spin physics, such as the implementation of the Heisenberg model in square arrays, and the study of spin transport in 1D. We first benchmark the Hamiltonian engineering for two atoms, and then demonstrate the freezing of the magnetization on an initially magnetized 2D array. Finally, we explore the dynamics of 1D domain wall systems with both periodic and open boundary conditions. We systematically compare our data with numerical simulations and assess the residual limitations of the technique as well as routes for improvements. The geometrical versatility of the platform, combined with the flexibility of the simulated Hamiltonians, opens exciting prospects in the field of quantum simulation, quantum information processing and quantum sensing.
description: 10 pages, 4 main figures, 2 supplementary figures
The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells.
Creators: name: Sergeant, A
name: Holley-Guthrie, E
name: Gutsch, D
name: Giot, J F
name: Kenney, S C
name: Zhang, Q
name: Bender, T
name: Quinlivan, E B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Regulation of replicative functions in the Epstein-Barr virus (EBV) genome is mediated through activation of a virally encoded transcription factor, Z (BZLF1). We have shown that the Z gene product, which binds to AP-1 sites as a homodimer and has sequence similarity to c-Fos, can efficiently activate the EBV early promoter, BMRF1, in certain cell types (i.e., HeLa cells) but not others (i.e., Jurkat cells). Here we demonstrate that the c-myb proto-oncogene product, which is itself a DNA-binding protein and transcriptional transactivator, can interact synergistically with Z in activating the BMRF1 promoter in Jurkat cells (a T-cell line) or Raji cells (an EBV-positive B-cell), whereas the c-myb gene product by itself has little effect. The simian virus 40 early promoter is also synergistically activated by the Z/c-myb combination. Synergistic transactivation of the BMRF1 promoter by the Z/c-myb combination appears to involve direct binding by the Z protein but not the c-myb protein. A 30-bp sequence in the BMRF1 promoter which contains a Z binding site (a consensus AP-1 site) is sufficient to transfer high-level lymphoid-specific responsiveness to the Z/c-myb combination to a heterologous promoter. That the c-myb oncogene product can interact synergistically with an EBV-encoded member of the leucine zipper protein family suggests c-myb is likely to engage in similar interactions with cellularly encoded transcription factors.
Surface gravity of compact non-degenerate horizons under the dominant energy condition
Creators: name: Gurriaran, Sebastian
name: Minguzzi, Ettore
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We prove that under the dominant energy condition any non-degenerate smooth compact totally geodesic horizon admits a smooth tangent vector field of constant non-zero surface gravity. This result generalizes previous work by Isenberg and Moncrief, and by Bustamante and Reiris to the non-vacuum case, the vacuum case being given a largely independent proof. Moreover, we prove that any such achronal non-degenerate horizon is actually a Cauchy horizon bounded on one side by a chronology violating region.
description: Latex, 37 pages, 2 figures. v2: added appendix and one figure, expanded introduction
An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity.
Creators: name: Kenna, M
name: McCammon, M
name: Stevens, A
name: Douglas, M G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: An essential gene, designated HKE1/RAT1, has been isolated from the yeast Saccharomyces cerevisiae and characterized. The gene encodes a protein of 116 kDa (p116) and has significant homology to another yeast gene (XRN1/KEM1) encoding a related protein (p175) with 5'-->3' exonuclease activity as well as activities involving chromosomal DNA pairing and mechanics. Preliminary analysis of an hke1ts mutant reveals a precipitous decline in the translation of mRNA at the nonpermissive temperature. Sporulation of heterozygous HKE1/hke1::URA3 diploids reveals that this gene, unlike the highly related XRN1/KEM1 gene, is essential for cell viability. Overexpression of the homologous gene product, p175, failed to rescue cells lacking a functional p116. In vitro studies demonstrate that p116 is a protein with 5'-->3' exoribonuclease activity, a major activity of the related p175. An immunoreactive RNase activity of 116 kDa is abolished with antiserum against p116. Both the level of this protein and the RNase activity correlate with HKE1 gene dosage. The RNase activity purifies coincidentally with a previously described 116-kDa RNase having 5'-->3' exoribonuclease activity.
Forward and Inverse Modelling Approaches for Prediction of Light Stimulus from Electrophysiological Response in Plants
Creators: name: Chatterjee, Shre Kumar
name: Ghosh, Sanmitra
name: Das, Saptarshi
name: Manzella, Veronica
name: Vitaletti, Andrea
name: Masi, Elisa
name: Santopolo, Luisa
name: Mancuso, Stefano
name: Maharatna, Koushik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Dynamical Systems (math.DS)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: In this paper, system identification approach has been adopted to develop a novel dynamical model for describing the relationship between light as an environmental stimulus and the electrical response as the measured output for a bay leaf (Laurus nobilis) plant. More specifically, the target is to predict the characteristics of the input light stimulus (in terms of on-off timing, duration and intensity) from the measured electrical response - leading to an inverse problem. We explored two major classes of system estimators to develop dynamical models - linear and nonlinear - and their several variants for establishing a forward and also an inverse relationship between the light stimulus and plant electrical response. The best class of models are given by the Nonlinear Hammerstein-Wiener (NLHW) estimator showing good data fitting results over other linear and nonlinear estimators in a statistical sense. Consequently, a few set of models using different functional variants of NLHW has been developed and their accuracy in detecting the on-off timing and intensity of the input light stimulus are compared for 19 independent plant datasets (including 2 additional species viz. Zamioculcas zamiifolia and Cucumis sativus) under similar experimental scenario.
description: 25 pages, 14 figures
Community-scale Big Data Reveals Disparate Impacts of the Texas Winter Storm of 2021 and its Managed Power Outage
Creators: name: Lee, Cheng-Chun
name: Maron, Mikel
name: Mostafavi, Ali
Publisher: name: arXiv
Year: 2021
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Aggregated community-scale data could be harnessed to allow insights into the disparate impacts of managed power outages, burst pipes, and food inaccessibility during extreme weather events. During Winter Storm Uri in February 2021, Texas power-generating plant operators resorted to rolling blackouts to prevent wider collapse of the whole power grid when power demand overwhelmed supply. In this study, we collected community-scale big data (e.g., digital trace and crowdsourced data) in the context of the winter storm, which brought historically low temperatures, snow, and ice to the entire state of Texas. By analyzing this data, we can infer the extent of disparities in storm-related impacts on vulnerable populations. In addition to assessing disparate impacts of the managed power outage, this study also examined the extent of burst pipes and disrupted access to food. Using statistical and trend classification analyses, the results highlight the spatial and temporal patterns of impacts for subpopulations in Harris County, Texas, within which the city of Houston is located. In particular, findings show significant disparity in the extent and duration of power outages experienced by low-income and minority groups. This finding suggests that the existence of inequality in the management and implementation of the power outage. Also, the extent of burst pipes and disrupted food access were more severe for low-income and minority groups. These findings suggest implications for understanding the disparate impacts of extreme weather events on vulnerable populations; in particular, the findings could provide insights allowing infrastructure operators to enhance social equality considerations during managed service disruptions in such events. The results and findings demonstrate the value of community-scale big data sources for rapid impact assessment in the aftermath of extreme weather events.
Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange
Creators: name: Jelescu, Ileana O.
name: de Skowronski, Alexandre
name: Geffroy, Françoise
name: Palombo, Marco
name: Novikov, Dmitry S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Medical Physics (physics.med-ph)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Biophysical models of diffusion in white matter are based on what is now commonly referred to as the "Standard Model" (SM) of non-exchanging anisotropic Gaussian compartments. In this work, we focus on diffusion MRI in gray matter, which requires rethinking basic microstructure modeling blocks. In particular, at least three contributions beyond the SM need to be considered: water exchange across the cell membrane - between neurites and the extracellular space; non-Gaussian diffusion along neuronal and glial processes - resulting from structural disorder; and signal contribution from soma. For the first contribution, we propose Neurite Exchange Imaging (NEXI) as an extension of the SM of diffusion, which builds on the anisotropic Kärger model of two exchanging compartments. Using datasets acquired at multiple diffusion weightings (b) and diffusion times (t) in the rat brain in vivo, we show that for the investigated diffusion time window (~10-45 ms) there is minimal diffusivity time-dependence and more pronounced kurtosis decay with time in gray matter, which is well fit by the exchange model. Moreover, we observe lower signal for longer diffusion times at high b. In light of these observations, we identify exchange as the mechanism that best explains these signal signatures in both low-b and high-b regime, and thereby propose NEXI as the minimal model for gray matter microstructure mapping. We finally highlight multi-b multi-t acquisitions protocols as being best suited to estimate NEXI model parameters reliably. Using this approach, we estimate the inter-compartment water exchange time to be 15 - 60 ms in the rat cortex and hippocampus in vivo, which is of the same order or shorter than the diffusion time in typical diffusion MRI acquisitions. This suggests water exchange as an essential component for interpreting diffusion MRI measurements in gray matter.
Defective replication of psoralen adducts detected at the gene-specific level in xeroderma pigmentosum variant cells.
Creators: name: Misra, R R
name: Vos, J M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Replication of damaged DNA is suspected to play an important role in cell cycle, genetic stability, and survival pathways. Using psoralen photoaddition as prototype DNA damage and the renaturing agarose gel electrophoresis technique to measure DNA cross-linking in individual genes, Vos and Hanawalt previously observed efficient bypass replication of psoralen monoadducts in human genes (J.-M. H. Vos and P. C. Hanawalt, Cell 50:789-799, 1987). To understand the mechanism of bypass replication in human cells, mutants affected in such a process would be useful. We now report that cells from individuals suffering from the hereditary recessive syndrome xeroderma pigmentosum variant (XPV) are hypersensitive to killing induced by photoactivated psoralen. In addition, analysis of psoralen-mediated DNA cross-linking in the rRNA genes indicated that although repair of psoralen adducts was similar to that of normal individuals, XPV cells were markedly deficient in the ability to bypass psoralen adducts during replication; in comparison with normal cells, approximately half as many monoadducts were bypassed during replication in XPV cells. Furthermore, in contrast to normal cells, replication of interstrand cross-links was not detected in XPV. This is the first demonstration of a deficiency in bypass replication detected at the gene-specific level in vivo. A model involving a strand-specific defect in recombinational bypass in XPV is proposed.
Charge-dependent anisotropic flow in high-energy heavy-ion collisions from relativistic resistive magneto-hydrodynamic expansion
Creators: name: Nakamura, Kouki
name: Miyoshi, Takahiro
name: Nonaka, Chiho
name: Takahashi, Hiroyuki R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We have investigated the charge-dependent anisotropic flow in high-energy heavy-ion collisions, using relativistic resistive magneto-hydrodynamics (RRMHD). We consider the optical Glauber model as an initial model of the quark-gluon plasma (QGP) and the solution of the Maxwell equations with source term of the charged particles in two colliding nuclei as initial electromagnetic fields. The RRMHD simulation is performed with these initial conditions in Au-Au and Cu-Au collisions at $\sqrt{s_{\mathrm{NN}}} = 200$ GeV. We have calculated the charge-odd contribution to the directed flow $Δv_1$ and elliptic flow $Δv_2$ in both collisions based on electric charge distributions as a consequence of RRMHD. Our results show that the $Δv_1$ and $Δv_2$ are approximately proportional to the electrical conductivity ($σ$) of the medium. In the $σ=0.023~\mathrm{fm}^{-1}$ case, our result of $Δv_1$ is consistent with STAR data in Au-Au collisions. Furthermore, in Cu-Au collisions, $Δv_1$ has a non-zero value at $η= 0$. We conclude that the charge-dependent anisotropic flow is a good probe to extract the electrical conductivity of the QGP medium in high-energy heavy-ion experiments.
description: 10 pages, 9 figures
La succion non-nutritive chez l'enfant prématuré
Creators: name: Sari, Yasmina
name: Augsburger, Sandra
Publisher: name: Unknown
Year: 0

description: Le travail que nous avons réalisé se présente sous la forme d’une revue de littérature, que nous avons menée pendant plus d’une année. La problématique a été précisée au cours de l’élaboration du travail. Nous avons finalement abouti à la question suivante : « Quels sont les effets de la stimulation orale par la succion non-nutritive sur l’enfant né avant 35 semaines de gestation hospitalisé dans un service de néonatologie lors de la phase de transition entre l’alimentation par gavage et l’alimentation orale autonome ? ». En nous intéressant à cette question, nous avions comme objectif de travailler sur une problématique actuelle et dans un contexte pédiatrique en ciblant une population d’enfants prématurés. De plus, nous voulions développer un sujet nous permettant d’apporter certaines pistes d’améliorations pouvant être utiles à la pratique. Afin de constituer cette revue de littérature, nous avons débuté par la recherche d’informations générales dans un premier temps, sur les difficultés d’alimentation des nouveau-nés prématurés ainsi que sur les différentes formes de stimulation existantes dans la pratique. Nous avons récolté des données à l’aide de diverses revues de littératures et d’articles scientifiques. Après les premières recherches et l’analyse des données récoltées, nous avons pu préciser notre question afin d’entreprendre davantage de recherches spécifiques et ciblées. Nous avons utilisé les bases de données que nous avions à notre disposition, afin de rechercher des articles scientifiques. Après avoir trouvé les différentes informations dont nous avions besoin, nous avons pu apporter un regard critique sur ces dernières afin de développer des pistes de réponses et de réflexions quant à notre problématique et à notre question initiale. Nous avons pu constater que la stimulation non-nutritive est généralement considérée comme aidante et bénéfique pour les enfants prématurés de moins de 35 semaines de gestation afin d’accélérer la phase de transition entre l’alimentation par gavage et l’alimentation orale autonome. De plus, l’élaboration de cette revue de littérature nous a permis d’identifier et d’apporter des informations précises quant aux effets spécifiques de la stimulation non-nutritive. En effet, nous avons remarqué que cela permet de débuter l’alimentation orale plus rapidement, que la quantité de lait ingérée est augmentée, que le temps d’hospitalisation est diminué et que, pour terminer, les caractéristiques de succion (rafale de succion, succion et pause) de l’enfant prématuré peuvent être modifiées. Finalement, ce travail, nous a permis de développer différentes perspectives et approches réflexives concernant la recherche et la pratique infirmière.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
The lifetime of the electroweak vacuum and sensitivity to Planck scale physics
Creators: name: Branchina, Vincenzo
name: Messina, Emanuele
name: Sher, Marc
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: If the Standard Model (SM) is valid up to extremely high energy scales, then the Higgs potential becomes unstable at approximately $10^{11}$ GeV. However, calculations of the lifetime of the SM vacuum have shown that it vastly exceeds the age of the Universe. It was pointed out by two of us (VB,EM) that these calculations are extremely sensitive to effects from Planck scale higher-dimensional operators and, without knowledge of these operators, firm conclusions about the lifetime of the SM vacuum cannot be drawn. The previous paper used analytical approximations to the potential and, except for Higgs contributions, ignored loop corrections to the bounce action. In this work, we do not rely on any analytical approximations and consider all contributions to the bounce action, confirming the earlier result. It is surprising that the Planck scale operators can have such a large effect when the instability is at $10^{11}$ GeV. There are two reasons for the size of this effect. In typical tunneling calculations, the value of the field at the center of the critical bubble is much larger than the point of the instability; in the SM case, this turns out to be numerically within an order of magnitude of the Planck scale. In addition, tunneling is an inherently non-perturbative phenomenon, and may not be as strongly suppressed by inverse powers of the Planck scale. We include effective $Φ^6$ and $Φ^8$ Planck-scale operators and show that they can have an enormous effect on the tunneling rate.
description: 34 pages, 10 figures
title: L'infirmière, un soutien pour le lien d'attachement
title: quelles interventions infirmières en néonatologie favorisent l'élaboration du lien d'attachement entre les nouveau-nés prématurés et leurs parents, plus spécifiquement avec leurs pères ?
titleType: Subtitle
Creators: name: FROSIO, Noémie
name: GINDROZ, Héloïse
Publisher: name: Unknown
Year: 0
Subjects: subject: néonatologie
subject: prématuré
subject: attachement
subject: relation parents-enfants
subject: rôle infirmier

description: Le contexte de notre revue de littérature se situe au sein des soins intensifs de néonatologie. Ce type de service accueille des nouveau-nés prématurés, ainsi que des nouveau-nés à terme, nécessitant des soins spécifiques. Les populations touchées par notre question sont les nouveau-nés prématurés, leurs parents, en particulier les pères, ainsi que les infirmières. Nous avons répertorié les principaux résultats de notre travail en trois parties La première catégorie des résultats touche les perceptions des infirmières concernant leur contribution dans le processus d’attachement entre les parents et leur nouveau-né prématuré. Ces dernières sont conscientes de l’importance de leur rôle. La seconde partie traite de la comparaison entre les pères et les mères concernant leur perception de l’attachement ainsi que la communication des infirmières. Les résultats démontrent qu’il existe des différences considérables entre les mères et les pères. La dernière partie comprend prioritairement les pères. Les principaux résultats concernent leurs perceptions et démontrent que ces derniers ont des priorités, ainsi que des besoins spécifiques. La naissance du lien d’attachement avec leur nouveau-né prématuré dépend de plusieurs facteurs, notamment de la proximité physique. Les principales perspectives identifiées sont les suivantes. Tout d’abord, la nécessité de réaliser des recherches infirmières en Suisse, afin d’identifier les besoins et les particularités des pères de nouveau-nés prématurés hospitalisés dans notre pays. Ensuite, nous avons réfléchi à une étude comparant un groupe de pères ayant la possibilité de rester auprès de leur bébé, et un second n’ayant pas cette possibilité, le but étant d’observer leur perception concernant leur processus d’attachement avec leur nouveau-né.
A microfluidic platform for high-throughput multiplexed protein quantitation
Creators: name: Volpetti, Francesca
name: Garcia-Cordero, Jose
name: Maerkl, Sebastian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\b{eta}, TNF-α, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.
Ratios of jet and hadron spectra at LHC energies: measuring high-$p_T$ suppression without a $pp$ reference
Creators: name: Brewer, Jasmine
name: Huss, Alexander
name: Mazeliauskas, Aleksas
name: van der Schee, Wilke
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We analyze the reliability of several techniques for computing jet and hadron spectra at different collision energies. This is relevant for discovering energy loss in the upcoming oxygen-oxygen (OO) run at the LHC, for which a reference pp run is currently not planned. For hadrons and jets we compute the ratio of spectra between different pp collision energies in perturbative QCD, which can be used to construct a reference spectrum. Alternatively, it can be interpolated from measured spectra at nearby energies. We estimate the precision of both strategies for the spectra ratio relevant to the oxygen run, and conclude that the central values agree to 4% accuracy for hadrons and 2% accuracy for jets. Finally we propose taking the ratio of OO and pp spectra at different collision energies, which cleanly separates the experimental measurement and theoretical computation.
description: 10 pages, 11 figures, v2 published version
Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells.
Creators: name: Chae, C B
name: Choi, Y C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: In contrast to many other genes containing a CpG island, the testis-specific H2B (TH2B) histone gene exhibits tissue-specific methylation patterns in correlation with gene activity. Characterization of the methylation patterns within a 20-kb segment containing the TH2A and TH2B genes in comparison with that in a somatic histone cluster revealed that: (i) the germ cell-specific unmethylated domain of the TH2A and TH2B genes is defined as a small region surrounding the CpG islands of the TH2A and TH2B genes and (ii) somatic histone genes are unmethylated in both liver and germ cells, like other genes containing CpG islands, whereas flanking sequences are methylated. Transfection of in vitro-methylated TH2B, somatic H2B, and mouse metallothionein I constructs into F9 embryonal carcinoma cells revealed that the CpG islands of the TH2A and TH2B genes were demethylated like those of the somatic H2A and H2B genes and the metallothionein I gene. The demethylation of those CpG islands became significantly inefficient at a high number of integrated copies and a high density of methylated CpG dinucleotides. In contrast, three sites in the somatic histone cluster, of which two sites are located in the long terminal repeat of an endogenous retrovirus-like sequence, were efficiently demethylated even at a high copy number and a high density of methylated CpG dinucleotides. These results suggest two possible mechanisms for demethylation in F9 cells and methylation of CpG islands of the TH2A and TH2B genes at the postblastula stage during embryogenesis.
A Simple Proof of Magnetic and Electric Aharonov-Bohm Effects
Creators: name: Eskin, Gregory
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Magnetic Aharonov-Bohm effect (AB effect) was studied in hundreds of papers starting with the seminal paper of Aharonov and Bohm [AB] published in 1959. We give a new proof of the magnetic Aharonov-Bohm effect without using the scattering theory and the theory of inverse boundary value problems. We consider separately the cases of one and several obstacles. The electric AB effect was studied much less. We give the first proof of the electric AB effect in domains with moving boundaries. When the boundary does not move with the time the electric AB effect is absent.
description: Final version of the first half of the arXiv:1007.3979. Note the title change
Lorentz violation from gamma-ray bursts
Creators: name: Zhang, Shu
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The constancy of light speed is a basic assumption in Einstein's special relativity, and consequently the Lorentz invariance is a fundamental symmetry of space-time in modern physics. However, it is speculated that the speed of light becomes energy-dependent due to the Lorentz invariance violation~(LV) in various new physics theories. We analyse the data of the energetic photons from the gamma-ray bursts (GRBs) by the Fermi Gamma-Ray Space Telescope, and find more events to support the energy dependence in the light speed with both linear and quadratic form corrections. We provide two scenarios to understand all the new-released Pass~8 data of bright GRBs by the Fermi-LAT Collaboration, with predictions from such scenarios being testable by future detected GRBs.
description: 7 latex pages, 2 figures, final version for journal publication
La participation de l'adolescent à la prise de décision thérapeutique
Creators: name: BESSON, Delphine
name: ROMON, Roxane
Publisher: name: Unknown
Year: 0
Subjects: subject: adolescent
subject: fin de vie
subject: traitement
subject: décision
subject: patient
subject: volonté
subject: éthique

description: Cette revue de littérature porte sur le thème de la participation des adolescents à la prise de décision thérapeutique. Nous voulions d’abord savoir s’ils peuvent participer aux décisions au regard de l’éthique et du droit. Le processus décisionnel est, comme son nom l’indique, un cheminement vers la prise de décision, qui en est l’aboutissant. Notre problématique s’inscrit dans le contexte des soins à l’adolescent atteint d’une maladie grave, dans une perspective de fin de vie. Elle se situe dans le système sanitaire vaudois, en lien direct avec le respect de la volonté du patient et l’amélioration de sa qualité de vie. Nous souhaitons ensuite confronter cette problématique à la littérature scientifique selon une méthodologie rigoureuse. Les résultats obtenus nous confirment que l’adolescent peut participer à la prise de décision sous quelques conditions. La discussion précédant la prise de décision est parfois facilitée par certaines affections mais reste indispensable au processus décisionnel. Des éléments favorisant ou entravant la participation de l’adolescent sont relevés dans les huit articles de recherche retenus. A noter que la participation à la prise de décision apporte au patient des bienfaits tels que l’amélioration de l’estime de soi ou la diminution du stress. Les perspectives pour la pratique se déclinent en termes d’éthique relationnelle, de formation et de processus évolutif. Le thème abordé par cette revue de littérature est encore peu exploré ; en effet, la recherche a débuté dans les années nonante. Il est donc possible d’entreprendre des projets de recherche afin de l’explorer davantage. Nous émettons en conclusion des sujets de recherche tels que la formation au regard du transfert des connaissances tout comme les critères spécifiques permettant d’assurer la participation d’un adolescent à la prise de décision.
Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).
Creators: name: Duckett, C S
name: Schmid, R M
name: Huang, E S
name: Nabel, G J
name: Perkins, N D
name: Kowalik, T F
name: Baldwin, A S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Inducible expression of human immunodeficiency virus (HIV) is regulated by a cellular transcription factor, nuclear factor kappa B (NF-kappa B). NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DNA elements have been isolated. We have previously found that NFKB2(p49/p52) acts in concert with RelA(p65) to stimulate the HIV enhancer in Jurkat T-leukemia cells. Here we examine the biochemical basis for the transcriptional regulation of HIV by NFKB2. Using Scatchard analysis, we have determined the dissociation constants of homodimeric p49 and heterodimeric p49/p65 for binding to the HIV kappa B site. p49 has a approximately 18-fold-lower affinity for the HIV kappa B site (KD = 69.1 pM) than does the approximately 50-kDa protein NFKB1(p50) derived from p105 (KD = 3.9 pM). In contrast, the affinity of heterodimeric NFKB2(p49)/RelA(p65) for this site is approximately 6-fold higher (KD = 11.8 pM) than that of p49 alone. Consistent with these findings, in vitro transcription was stimulated 18-fold by the addition of preformed, heterodimeric NFKB2(p49)/RelA(p65) protein. Transcriptional activation of the HIV enhancer was also subject to regulation by recently cloned I kappa B-alpha(MAD-3). Recombinant I kappa B-alpha(MAD-3) inhibited the DNA binding activity of p65, p49/p65, and p50/p65 but stimulated the binding of NFKB2(p49) or NFKB1(p50). Functional activation of an HIV reporter plasmid by p49/p65 in transiently transfected Jurkat T-leukemia cells was also inhibited by coexpression of MAD-3. These data suggest that binding of the NFKB2 subunit to the HIV enhancer is facilitated by RelA(p65) and that this NFKB2(p49)/p65 heterodimeric complex mediates transcriptional activation which is subject to regulation by MAD-3.
Wire width and density dependence of the crossover in the peak of the static structure factor from $2k_\text{F}$ $\rightarrow$ $4k_\text{F}$ in one-dimensional paramagnetic electron gases
Creators: name: Girdhar, Ankush
name: Ashokan, Vinod
name: Sharma, Rajesh O.
name: Drummond, N. D.
name: Pathak, K. N.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We use the variational quantum Monte Carlo (VMC) method to study the wire width ($b$) and electron density ($r_\text{s}$) dependences of the ground-state properties of quasi-one-dimensional paramagnetic electron fluids. The onset of a quasi-Wigner crystal phase is known to depend on electron density, and the crossover occurs in the low density regime. We study the effect of wire width on the crossover of the dominant peak in the static structure factor from $k=2k_\text{F}$ to $k=4k_\text{F}$. It is found that for a fixed electron density, in the charge structure factor the crossover from the dominant peak occurring at $2k_\text{F}$ to $4k_\text{F}$ occurs as the wire width decreases. Our study suggests that the crossover is due to interplay of both $r_\text{s}$ and $b
title: Political economy and population health: from theory to an empirical assessment of the impact of austerity on mortality trends
Creators: name: McCartney, Gerard
Publisher: name: University of Glasgow
Year: 2022

description: The life expectancy of most high income countries had increased consistently over the second half of the 20th Century. However, after around 2012 these improving trends stalled in many countries. This thesis seeks to explain these trends through a political economy lens. There are three central arguments made in this thesis. First, that health is best defined as a structural, functional and emotional state that is compatible with effective life as an individual and as a member of society; and that health inequalities are best defined as the systematic, avoidable and unfair differences in health outcomes that can be observed between populations, between social groups within the same population, or as a gradient across a population ranked by social position. Second, that political economy is crucial to understanding the health of populations. The existing evidence linking political economy to population health was systematically reviewed and synthesised. Although there were risks of bias, social democratic welfare states, higher public spending, fair trade policies, extensions to compulsory education provision, microfinance initiatives in low-income countries, health and safety policy, improved access to health care, and high-quality affordable housing were found to have positive impacts on population health. ‘Neoliberal’ restructuring was associated with increased health inequalities. Higher income inequality was associated with lower self-rated health and higher mortality. Third, countries with more austere policy in recent decades experienced slower improvements in mortality, especially when measured as changes in Government Expenditure and Public Social Spending, and when implemented during economic downturns, albeit with imprecise effect estimates. The stalled mortality trends observed across many high income countries is therefore likely to be at least partly due to austerity policies.