cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics
Creators: name: Benhabbour, Soumya Rahima
name: Kashuba, Angela D. M.
name: Dayton, Paul A.
name: Cottrell, Mackenzie L.
name: King, Jasmine L.
name: Shrivastava, Roopali
name: Joiner, Jordan B.
name: Howard, Sarah Anne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Due to the versatility of the in situ forming implant (ISFI) drug delivery system, it is crucial to understand the effects of formulation parameters for clinical translation. We utilized ultrasound imaging and pharmacokinetics (PK) in mice to understand the impact of administration route, injection volume, and drug loading on ISFI formation, degradation, and drug release in mice. Placebo ISFIs injected subcutaneously (SQ) with smaller volumes (40 μL) exhibited complete degradation within 30–45 days, compared to larger volumes (80 μL), which completely degraded within 45–60 days. However, all dolutegravir (DTG)-loaded ISFIs along the range of injection volumes tested (20–80 μL) were present at 90 days post-injection, suggesting that DTG can prolong ISFI degradation. Ultrasound imaging showed that intramuscular (IM) ISFIs flattened rapidly post administration compared to SQ, which coincides with the earlier Tmax for drug-loaded IM ISFIs. All mice exhibited DTG plasma concentrations above four times the protein-adjusted 90% inhibitory concentration (PA-IC90) throughout the entire 90 days of the study. ISFI release kinetics best fit to zero order or diffusion-controlled models. When total administered dose was held constant, there was no statistical difference in drug exposure regardless of the route of administration or number of injections.
Sonnenfleckenzeichnung Nr. 212.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.09.1985, 08:30, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 236.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.10.1985, 10:00, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 294.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.12.1985, 10:00, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Voices from ‘backstage’: London nightworkers before and during the pandemic
Creators: name: Julius-Cezar MacQuarie
name: Martin, Shirley
Publisher: name: figshare
Year: 2020
Subjects: subject: 160104 Social and Cultural Anthropology
subject: FOS: Sociology

description: Nightworkers, who move in the night as a means of earning a living, remain largely invisible from the mainstream society, pandemic times or not. Yet their fears, uncertainties and acts of courage are equally revealing of what it means to be mobile in these times of immobility.
This guest blog is part of the COMPAS Coronavirus and Mobility Forum.
(500628) William Creighton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Resonant magneto-tunneling between normal and ferromagnetic electrodes in relation to the three-terminal spin transport
Creators: name: Yue, Z.
name: Raikh, M. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The recently suggested mechanism [Y. Song and H. Dery, Phys. Rev. Lett. 113, 047205 (2014)] of the three-terminal spin transport is based on the resonant tunneling of electrons between ferromagnetic and normal electrodes via an impurity. The sensitivity of current to a weak external magnetic field stems from a spin blockade, which, in turn, is enabled by strong on-site repulsion. We demonstrate that this sensitivity exists even in the absence of repulsion when a single-particle description applies. Within this description, we calculate exactly the resonant-tunneling current between the electrodes. The mechanism of magnetoresistance, completely different from the spin blocking, has its origin in the interference of virtual tunneling amplitudes. Spin imbalance in ferromagnetic electrode is responsible for this interference and the resulting coupling of the Zeeman levels. This coupling also affects the current in the correlated regime.
description: 8 pages, 7 figures
EMBRACE@Nancay: An Ultra Wide Field of View Prototype for the SKA
Creators: name: Torchinsky, S. A.
name: Olofsson, A. O. H.
name: Censier, B.
name: Karastergiou, A.
name: Serylak, M.
name: Renaud, P.
name: Taffoureau, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: A revolution in radio receiving technology is underway with the development of densely packed phased arrays for radio astronomy. This technology can provide an exceptionally large field of view, while at the same time sampling the sky with high angular resolution. Such an instrument, with a field of view of over 100 square degrees, is ideal for performing fast, all-sky, surveys, such as the "intensity mapping" experiment to measure the signature of Baryonic Acoustic Oscillations in the HI mass distribution at cosmological redshifts. The SKA, built with this technology, will be able to do a billion galaxy survey. I will present a very brief introduction to radio interferometry, as well as an overview of the Square Kilometre Array project. This will be followed by a description of the EMBRACE prototype and a discussion of results and future plans.
description: to appear in proceedings of the INFIERI Summer School INtelligent Signal Processing for FrontIEr Research and Industry, Paris 2014
Does Venue of HIV Testing and Results Disclosure in the Context of a Research Study Affect Adolescent Health and Behavior? Results from a Study in Western Kenya
Creators: name: Luseno, Winnie Kavulani
name: Rennie, Stuart
name: Field, Samuel H.
name: Kwaro, Daniel
name: Odongo, Fredrick S.
name: Iritani, Bonita J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Ethical concerns about risks to minor adolescents participating in HIV prevention research is a barrier to their inclusion. One concern is whether HIV testing and results disclosure venue affects the health and behavior of adolescent participants. We assessed for differential effects on quality of life (QOL), depressive symptoms, and sexual behavior due to (1) testing venue (home or health facility) and (2) test result (HIV-positive, HIV-negative, indeterminate). We collected data at three timepoints (baseline, 2-month follow-up, 12-month follow-up) from 113 Kenyan adolescents aged 15–19 (51% female). We analyzed the data using linear mixed effects models for the QOL and depressive symptoms outcomes and a logistic model for the sexual behavior outcome. Results showed a small mental health benefit for adolescents tested for HIV at a health facility compared with home. There was little evidence that testing venue influenced sexual behavior or that test results moderated the effects of HIV testing across all outcomes. The decision to conduct HIV testing at home or a health facility may not be very consequential for adolescents’ health and behavior. Findings underscore the need to critically examine assumptions about adolescent vulnerability to better promote responsible conduct of HIV prevention research with youth in sub-Saharan Africa.
title: Μελέτη της θερμικής επεξεργασίας λατεριτών στην βελτιστοποίηση της λειοτρίβησης
Creators: name: Γκατσος Γεωργιος
Publisher: name: Technical University of Crete
Year: 2023

description: Το αντικέιμενο της εργασίας είναι η μελέτη της επίδρασης της πύρωσης λατερίτη Καστοριάς στην απόδοση της λειοτρίβησης του μεταλλεύματος αυτού. Η πύρωση ως μέθοδος προτιμάται στην βιομηχανία εμπλουτισμού, καθώς μπορεί να συμβάλλει στην αύξηση της ευθραυστότητας του υλικού, ενώ μειώνει την υγρασία του, γεγονός που ευνοεί την μετέπειτα επεξεργασία του μεταλλεύματος με ξηρές μεθόδους.
(500606) William Winship
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders
Creators: name: Virdee, Manjot S.
name: Mooney, Sandra M.
name: Saini, Nipun
name: Kwan, Sze Ting Cecilia
name: Helfrich, Kaylee K.
name: Smith, Susan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Prenatal alcohol exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alcohol (ALC) revealed that the hepatic metabolome of ALC and control (CON) dams were distinct, whereas that of ALC and CON fetuses were similar. Alcohol reduced maternal hepatic glucose content and enriched essential amino acid (AA) catabolites, N-acetylated AA products, urea content, and free fatty acids. These alterations suggest an attempt to minimize the glucose gap by increasing gluconeogenesis using AA and glycerol. In contrast, ALC fetuses had unchanged glucose and AA levels, suggesting an adequate draw of maternal nutrients, despite intensified stress on ALC dams. Maternal metabolites including glycolytic intermediates, AA catabolites, urea, and one-carbon-related metabolites correlated with fetal liver and brain weights, whereas lipid metabolites correlated with fetal body weight, indicating they may be drivers of fetal weight outcomes. Together, these data suggest that ALC alters maternal hepatic metabolic activity to limit glucose availability, thereby switching to alternate energy sources to meet the high-energy demands of pregnancy. Their correlation with fetal phenotypic outcomes indicates the influence of maternal metabolism on fetal growth and development.
Development of a subwavelength grating vortex coronagraph of topological charge 4 (SGVC4)
Creators: name: Delacroix, Christian
name: Absil, Olivier
name: Carlomagno, Brunella
name: Piron, Pierre
name: Forsberg, Pontus
name: Karlsson, Mikael
name: Mawet, Dimitri
name: Habraken, Serge
name: Surdej, Jean
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: One possible solution to achieve high contrast direct imaging at a small inner working angle (IWA) is to use a vector vortex coronagraph (VVC), which provides a continuous helical phase ramp in the focal plane of the telescope with a phase singularity in its center. Such an optical vortex is characterized by its topological charge, i.e., the number of times the phase accumulates 2π radians along a closed path surrounding the singularity. Over the past few years, we have been developing a charge-2 VVC induced by rotationally symmetric subwavelength gratings (SGVC2), also known as the Annular Groove Phase Mask (AGPM). Since 2013, several SGVC2s (or AGPMs) were manufactured using synthetic diamond substrate, then validated on dedicated optical benches, and installed on 10-m class telescopes. Increasing the topological charge seems however mandatory for cancelling the light of bright stars which will be partially resolved by future Extremely Large Telescopes in the near-infrared. In this paper, we first detail our motivations for developing an SGVC4 (charge 4) dedicated to the near-infrared domain. The challenge lies in the design of the pattern which is unrealistic in the theoretically perfect case, due to state-of-the-art manufacturing limitations. Hence, we propose a new realistic design of SGVC4 with minimized discontinuities and optimized phase ramp, showing conclusive improvements over previous works in this field. A preliminary validation of our concept is given based on RCWA simulations, while full 3D finite-difference time-domain simulations (and eventually laboratory tests) will be required for a final validation.
description: 9 pages
Blackfolds, Plane Waves and Minimal Surfaces
Creators: name: Armas, Jay
name: Blau, Matthias
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Minimal surfaces in Euclidean space provide examples of possible non-compact horizon geometries and topologies in asymptotically flat space-time. On the other hand, the existence of limiting surfaces in the space-time provides a simple mechanism for making these configurations compact. Limiting surfaces appear naturally in a given space-time by making minimal surfaces rotate but they are also inherent to plane wave or de Sitter space-times in which case minimal surfaces can be static and compact. We use the blackfold approach in order to scan for possible black hole horizon geometries and topologies in asymptotically flat, plane wave and de Sitter space-times. In the process we uncover several new configurations, such as black helicoids and catenoids, some of which have an asymptotically flat counterpart. In particular, we find that the ultraspinning regime of singly-spinning Myers-Perry black holes, described in terms of the simplest minimal surface (the plane), can be obtained as a limit of a black helicoid, suggesting that these two families of black holes are connected. We also show that minimal surfaces embedded in spheres rather than Euclidean space can be used to construct static compact horizons in asymptotically de Sitter space-times.
description: v2: 67pp, 7figures, typos fixed, matches published version
MODERATE HTTP API documentation D2.4 M29
Creators: name: Andrés, García Mangas
Publisher: name: Zenodo
Year: 2024

description: This publication is a static HTML site containing the documentation for the HTTP API of the MODERATE Platform. It represents a snapshot of the API at the time of submission of the related deliverable, although the API will continue to evolve in the future. The latest version can be dynamically generated from the repository. The documentation was automatically generated using Swagger Codegen from an API developed with FastAPI.
(500611) Thomas Younger
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(500614) Matilda Turner Dodd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Trends in the Management of Headache Disorders in US Emergency Departments: Analysis of 2007–2018 National Hospital Ambulatory Medical Care Survey Data
Creators: name: Orlova, Yulia
name: Chang, Ching-Yuan
name: Wilson, Debbie L.
name: Park, Haesuk
name: Lo-Ciganic, Wei-Hsuan
name: Hincapie-Castillo, Juan M.
name: Adkins, Lauren
name: Lipe, Abigale
name: Boren, Macy
name: Yang, Seonkyeong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: We examined trends in management of headache disorders in United States (US) emergency department (ED) visits. We conducted a cross-sectional study using 2007–2018 National Hospital Ambulatory Medical Care Survey data. We included adult patient visits (≥18 years) with a primary ED discharge diagnosis of headache. We classified headache medications by pharmacological group: opioids, butalbital, ergot alkaloids/triptans, acetaminophen/nonsteroidal anti-inflammatory drugs (NSAIDs), antiemetics, diphenhydramine, corticosteroids, and intravenous fluids. To obtain reliable estimates, we aggregated data into three time periods: 2007–2010, 2011–2014, and 2015–2018. Using multivariable logistic regression, we examined medication, neuroimaging, and outpatient referral trends, separately. Among headache-related ED visits, opioid use decreased from 54.1% in 2007–2010 to 28.3% in 2015–2018 (Ptrend < 0.001). There were statistically significant increasing trends in acetaminophen/NSAIDs, diphenhydramine, and corticosteroids use (all Ptrend < 0.001). Changes in butalbital (6.4%), ergot alkaloid/triptan (4.7%), antiemetic (59.2% in 2015–2018), and neuroimaging (37.3%) use over time were insignificant. Headache-related ED visits with outpatient referral for follow-up increased slightly from 73.3% in 2007–2010 to 79.7% in 2015–2018 (Ptrend = 0.02). Reflecting evidence-based guideline recommendations for headache management, opioid use substantially decreased from 2007 to 2018 among US headache-related ED visits. Future studies are warranted to identify strategies to promote evidence-based treatment for headaches (e.g., sumatriptan, dexamethasone) and appropriate outpatient referral and reduce unnecessary neuroimaging orders in EDs.
(500610) Charles Cuthbert Shafto
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Designing Environmental Messages to Discourage Red Meat Consumption: An Online Experiment
Creators: name: Hall, Marissa G.
name: Wistar, Alice
name: Taillie, Lindsey Smith
name: Bercholz, Maxime
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Reducing red meat consumption in high-consuming countries is critical for mitigating climate change and preventing chronic disease. This study tested the effectiveness of messages conveying the worsening or reduction of environmental harms at discouraging red meat consumption. 1078 U.S. adults viewed seven messages in an online survey highlighting the reduction or worsening of environmental harms associated with eating red meat (between-subjects factor) and rated the messages on how much they discouraged them from wanting to buy beef. Each message highlighted a different environmental harm: deforestation, climate change, water shortages, biodiversity loss, carbon footprint, greenhouse gas emissions, or environment (within-subjects factor). No statistically significant difference was found between the reduction and worsening of environmental harms conditions for most topics, though the worsening of harms frame slightly outperformed the reduction of harms frame for the ‘environment’ topic. ‘Environment’ was also the message topic that elicited the strongest response from participants overall. Latino participants, those with more than a high school degree, and those who consume beef once a week or less rated messages as more effective than non-Latino participants, those who completed high school or less, and those who consumed beef more than once a week. Future research should explore the effect of messages on behavioral outcomes.
Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms
Creators: name: Jiang, Wei
name: Nath, Bhupendra
name: Xu, Changqing
name: Mukhopadhyay, Somnath
name: Xu, Callie
name: Lichtman, Aron H.
name: Cravatt, Benjamin F.
name: Yadav-Samudrala, Barkha J.
name: Fitting, Sylvia
name: Ignatowska-Jankowska, Bogna M.
name: Niphakis, Micah J.
name: Mistry, Twisha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: (1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB tone has potential protective effects against HIV-1 Tat (a key HIV transactivator of transcription) protein-induced alterations in synaptic activity. (2) Methods. Whole-cell patch-clamp recordings were performed to assess inhibitory GABAergic neurotransmission in prefrontal cortex slices of Tat transgenic male and female mice, in the presence and absence of the fatty acid amide hydrolase (FAAH) enzyme inhibitor PF3845. Western blot and mass spectrometry analyses assessed alterations of cannabinoid receptor and enzyme protein expression as well as endogenous ligands, respectively, to determine the impact of Tat exposure on the eCB system. (3) Results. GABAergic activity was significantly altered upon Tat exposure based on sex, whereas the effectiveness of PF3845 to suppress GABAergic activity in Tat transgenic mice was not altered by Tat or sex and involved CB1R-related mechanisms that depended on calcium signaling. Additionally, our data indicated sex-dependent changes for AEA and related non-eCB lipids based on Tat induction. (4) Conclusion. Results highlight sex- and/or Tat-dependent alterations of GABAergic activity and eCB signaling in the prefrontal cortex of Tat transgenic mice and further increase our understanding about the role of FAAH inhibition in neuroHIV.
Periodic transmission peaks in non-periodic disordered one-dimensional photonic structures
Creators: name: Kriegel, Ilka
name: Scotognella, Francesco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A better understanding of the optical properties of a device structure characterized by a random arrangement of materials with different dielectric properties at a length scale comparable to the wavelength of light is crucial for the realization of new optical and optoelectronic devices. Here we have studied the light transmission of disordered photonic structures made with two and three different materials, characterized by the same optical thickness. In their transmission spectra a formation of peaks, with a transmission of up to 75%, is evident. The spectral position of such peaks is very regular, which is a result of the constraint that all layers have the same optical thickness. This gives rise to a manifold of applications such as new types of bandpass filters and resonators for distributed feedback lasers.
description: 11 pages, 4 figures
(500596) Thomas Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mapping Forest Aboveground Biomass Using Multisource Remotely Sensed Data
Creators: name: Woodcock, Curtis
name: Frankenberg, Elizabeth
name: Pavelsky, Tamlin
name: Zhang, Yulong
name: Ehlers, Dekker
name: Wang, Chao
name: Song, Conghe
name: Coulston, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The majority of the aboveground biomass on the Earth’s land surface is stored in forests. Thus, forest biomass plays a critical role in the global carbon cycle. Yet accurate estimate of forest aboveground biomass (FAGB) remains elusive. This study proposed a new conceptual model to map FAGB using remotely sensed data from multiple sensors. The conceptual model, which provides guidance for selecting remotely sensed data, is based on the principle of estimating FAGB on the ground using allometry, which needs species, diameter at breast height (DBH), and tree height as inputs. Based on the conceptual model, we used multiseasonal Landsat images to provide information about species composition for the forests in the study area, LiDAR data for canopy height, and the image texture and image texture ratio at two spatial resolutions for tree crown size, which is related to DBH. Moreover, we added RaDAR data to provide canopy volume information to the model. All the data layers were fed to a Random Forest (RF) regression model. The study was carried out in eastern North Carolina. We used biomass from the USFS Forest Inventory and Analysis plots to train and test the model performance. The best model achieved an R2 of 0.625 with a root mean squared error (RMSE) of 18.8 Mg/ha (47.6%) with the “out-of-bag” samples at 30 × 30 m spatial resolution. The top five most important variables include the 95th, 85th, 75th, and 50th percentile heights of the LiDAR points and their standard deviations of 85th heights. Numerous features from multiseasonal Sentinel-1 C-Band SAR, multiseasonal Landsat 8 imagery along with image texture features from very high-resolution imagery were selected. But the importance of the height metrics dwarfed all other variables. More tests of the conceptual model in places with a broader range of biomass and more diverse species composition are needed to evaluate the importance of other input variables.
Far infrared CO and H$_2$O emission in intermediate-mass protostars
Creators: name: Matuszak, M.
name: Karska, A.
name: Kristensen, L. E.
name: Herczeg, G. J.
name: Tychoniec, L.
name: van Kempen, T.
name: Fuente, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Intermediate-mass young stellar objects (YSOs) provide a link to understand how feedback from shocks and UV radiation scales from low to high-mass star forming regions. Aims: Our aim is to analyze excitation of CO and H$_2$O in deeply-embedded intermediate-mass YSOs and compare with low-mass and high-mass YSOs. Methods: Herschel/PACS spectral maps are analyzed for 6 YSOs with bolometric luminosities of $L_\mathrm{bol}\sim10^2 - 10^3$ $L_\odot$. The maps cover spatial scales of $\sim 10^4$ AU in several CO and H$_2$O lines located in the $\sim55-210$ $μ$m range. Results: Rotational diagrams of CO show two temperature components at $T_\mathrm{rot}\sim320$ K and $T_\mathrm{rot}\sim700-800$ K, comparable to low- and high-mass protostars probed at similar spatial scales. The diagrams for H$_2$O show a single component at $T_\mathrm{rot}\sim130$ K, as seen in low-mass protostars, and about $100$ K lower than in high-mass protostars. Since the uncertainties in $T_\mathrm{rot}$ are of the same order as the difference between the intermediate and high-mass protostars, we cannot conclude whether the change in rotational temperature occurs at a specific luminosity, or whether the change is more gradual from low- to high-mass YSOs. Conclusions: Molecular excitation in intermediate-mass protostars is comparable to the central $10^{3}$ AU of low-mass protostars and consistent within the uncertainties with the high-mass protostars probed at $3\cdot10^{3}$ AU scales, suggesting similar shock conditions in all those sources.
description: Accepted to Astronomy & Astrophysics. 4 pages, 5 figures, 3 tables
An Amine-Reactive Phenazine Ethosulfate (arPES)—A Novel Redox Probe for Electrochemical Aptamer-Based Sensor
Creators: name: Lee, Jinhee
name: Henley, Stephen
name: Ikebukuro, Kazunori
name: Sode, Koji
name: Nagata, Madoka
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Electrochemical aptamer-based biosensors (E-ABs) are attractive candidates for use in biomarker detection systems due to their sensitivity, rapid response, and design flexibility. There are only several redox probes that were employed previously for this application, and a combination of redox probes affords some advantages in target detection. Thus, it would be advantageous to study new redox probes in an E-AB system. In this study, we report the use of amine-reactive phenazine ethosulfate (arPES) for E-AB through its conjugation to the terminus of thrombin-binding aptamer. The constructed E-AB can detect thrombin by square-wave voltammetry (SWV), showing peak current at −0.15 V vs. Ag/AgCl at pH 7, which differs from redox probes used previously for E-ABs. We also compared the characteristics of PES as a redox probe for E-AB to methylene blue (MB), which is widely used. arPES showed stable signal at physiological pH. Moreover, the pH profile of arPES modified thrombin-binding aptamer revealed the potential application of arPES for a simultaneous multianalyte detection system. This could be achieved using different aptamers with several redox probes in tandem that harbor various electrochemical peak potentials. Our findings present a great opportunity to improve the current standard of biological fluid monitoring using E-AB.
(500603) Emily Mary Lyons
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Appendix 1 - Detailed search strategy
Creators: name: Ahmed, Salina
Publisher: name: figshare
Year: 2020
Subjects: subject: 110307 Gastroenterology and Hepatology
subject: FOS: Clinical medicine
subject: Health Care

description: Detailed search strategy for the study 'Experiences of ethnic minority patients who are living with a primary bowel condition or bowel-related symptoms of other chronic diseases: a systematic review'
The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
Creators: name: Wu, Xuedan
name: Ma, Xinrui
name: Wang, Li
name: Li, Bing
name: Wang, Xiaodong
name: Ding, Ransheng
name: Wu, Zhanhong
name: Stashko, Michael A.
name: Zhou, Yubai
name: Li, Zibo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: MerTK (Mer tyrosine kinase), a receptor tyrosine kinase, is ectopically or aberrantly expressed in numerous human hematologic and solid malignancies. Although a variety of MerTK targeting therapies are being developed to enhance outcomes for patients with various cancers, the sensitivity of tumors to MerTK suppression may not be uniform due to the heterogeneity of solid tumors and different tumor stages. In this report, we develop a series of radiolabeled agents as potential MerTK PET (positron emission tomography) agents. In our initial in vivo evaluation, [18F]-MerTK-6 showed prominent uptake rate (4.79 ± 0.24%ID/g) in B16F10 tumor-bearing mice. The tumor to muscle ratio reached 1.86 and 3.09 at 0.5 and 2 h post-injection, respectively. In summary, [18F]-MerTK-6 is a promising PET agent for MerTK imaging and is worth further evaluation in future studies.
Complex networks vulnerability to module-based attacks
Creators: name: da Cunha, Bruno Requião
name: González-Avella, Juan Carlos
name: Gonçalves, Sebastián
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In the multidisciplinary field of Network Science, optimization of procedures for efficiently breaking complex networks is attracting much attention from practical points of view. In this contribution we present a module-based method to efficiently break complex networks. The procedure first identifies the communities in which the network can be represented, then it deletes the nodes (edges) that connect different modules by its order in the betweenness centrality ranking list. We illustrate the method by applying it to various well known examples of social, infrastructure, and biological networks. We show that the proposed method always outperforms vertex (edge) attacks which are based on the ranking of node (edge) degree or centrality, with a huge gain in efficiency for some examples. Remarkably, for the US power grid, the present method breaks the original network of 4941 nodes to many fragments smaller than 197 nodes (4% of the original size) by removing mere 164 nodes (~3%) identified by the procedure. By comparison, any degree or centrality based procedure, deleting the same amount of nodes, removes only 22% of the original network, i.e. more than 3800 nodes continue to be connected after that
description: 8 pages, 8 figures
Magnetic Correlations in the Quasi-2D Semiconducting Ferromagnet CrSiTe$_3$
Creators: name: Williams, T. J.
name: Aczel, A. A.
name: Lumsden, M. D.
name: Nagler, S. E.
name: Stone, M. B.
name: Yan, J. -Q.
name: Mandrus, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Intrinsic, two-dimensional ferromagnetic semiconductors are an important class of materials for overcoming the limitations of dilute magnetic semiconductors for spintronics applications. CrSiTe$_3$ is a particularly interesting member of this class, since it can likely be exfoliated down to single layers, where T$_C$ is predicted to increase dramatically. Establishing the nature of the magnetism in the bulk is a necessary precursor to understanding the magnetic behavior in thin film samples and the possible applications of this material. In this work, we use elastic and inelastic neutron scattering to measure the magnetic properties of single crystalline CrSiTe$_3$. We find that there is a very small single ion anisotropy favoring magnetic ordering along the $c$-axis and that the measured spin waves fit well to a model where the moments are only weakly coupled along that direction. Finally, we find that both static and dynamic correlations persist within the $ab$-plane up to at least 300 K, strong evidence of this material's two-dimensional characteristics that are relevant for future studies on thin film and monolayer samples.
description: 8 pages, 5 figures
(500604) Arthur Scott Donkin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mechanisms of DNA Mobilization and Sequestration
Creators: name: Bloom, Kerry
name: Kolbin, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The entire genome becomes mobilized following DNA damage. Understanding the mechanisms that act at the genome level requires that we embrace experimental and computational strategies to capture the behavior of the long-chain DNA polymer, which is the building block for the chromosome. Long-chain polymers exhibit constrained, sub-diffusive motion in the nucleus. Cross-linking proteins, including cohesin and condensin, have a disproportionate effect on genome organization in their ability to stabilize transient interactions. Cross-linking proteins can segregate the genome into sub-domains through polymer–polymer phase separation (PPPS) and can drive the formation of gene clusters through small changes in their binding kinetics. Principles from polymer physics provide a means to unravel the mysteries hidden in the chains of life.
(500605) Henry King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Too Much Dietary Flexibility May Hinder, Not Help: Could More Specific Targets for Daily Food Intake Distribution Promote Glycemic Management among Youth with Type 1 Diabetes?
Creators: name: Mayer-Davis, Elizabeth
name: Cristello Sarteau, Angelica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Average glycemic levels among youth with type 1 diabetes (T1D) have worsened in some parts of the world over the past decade despite simultaneous increased uptake of diabetes technology, thereby highlighting the persistent need to identify effective behavioral strategies to manage glycemia during this life stage. Nutrition is fundamental to T1D management. We reviewed the evidence base of eating strategies tested to date to improve glycemic levels among youth with T1D in order to identify promising directions for future research. No eating strategy tested among youth with T1D since the advent of flexible insulin regimens—including widely promoted carbohydrate counting and low glycemic index strategies—is robustly supported by the existing evidence base, which is characterized by few prospective studies, small study sample sizes, and lack of replication of results due to marked differences in study design or eating strategy tested. Further, focus on macronutrients or food groups without consideration of food intake distribution throughout the day or day-to-day consistency may partially underlie the lack of glycemic benefits observed in studies to date. Increased attention paid to these factors by future observational and experimental studies may facilitate identification of behavioral targets that increase glycemic predictability and management among youth with T1D.
Modeling Secondary Phenotypes Conditional on Genotypes in Case–Control Studies
Creators: name: Slade, Gary D.
name: Cai, Jianwen
name: Bair, Eric
name: Brownstein, Naomi C.
name: Smith, Shad
name: Diatchenko, Luda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Traditional case–control genetic association studies examine relationships between case–control status and one or more covariates. It is becoming increasingly common to study secondary phenotypes and their association with the original covariates. The Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) project, a study of temporomandibular disorders (TMD), motivates this work. Numerous measures of interest are collected at enrollment, such as the number of comorbid pain conditions from which a participant suffers. Examining the potential genetic basis of these measures is of secondary interest. Assessing these associations is statistically challenging, as participants do not form a random sample from the population of interest. Standard methods may be biased and lack coverage and power. We propose a general method for the analysis of arbitrary phenotypes utilizing inverse probability weighting and bootstrapping for standard error estimation. The method may be applied to the complicated association tests used in next-generation sequencing studies, such as analyses of haplotypes with ambiguous phase. Simulation studies show that our method performs as well as competing methods when they are applicable and yield promising results for outcome types, such as time-to-event, to which other methods may not apply. The method is applied to the OPPERA baseline case–control genetic study.