cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
APC/C and SCF cyclin F  Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
Creators: name: DeCaprio, James A.
name: Mills, Christine A.
name: Lahiri, Debojyoti
name: Arceci, Anthony
name: Branigan, Timothy B.
name: Choudhury, Rajarshi
name: Emanuele, Michael J.
name: Kernan, Jennifer L.
name: Burke, Daniel J.
name: Bonacci, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor Cdh1 and APC/C(Cdh1) plays an important role in restricting S-phase entry and maintaining genome integrity. We describe a reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show that cyclin F, a cell-cycle-regulated substrate receptor (F-box protein) for the SCF, is targeted for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCF(cyclin F). Cyclin F loss impairs Cdh1 degradation and delays S-phase entry, and this delay is reversed by simultaneous removal of Cdh1. These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control. This mutual antagonism could be a feature of other oscillating systems.
How Fast are “Fast-Friends”? Do People Make Resilient Friendship-relevant Judgements of Strangers Within the First Minute of Interaction.
Creators: name: Benson, David
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Impression formation involves the use of swift automatic judgements in combination with controlled processing of incoming information to adjust those judgements. “Thin-slice” literature has also shown us that humans are capable of surprisingly accurate interpersonal judgements from small clips of expressive behavior. Although friendship does take time to develop, assessing others along dimensions that seem to affect friendship development during the acquaintance process often involve interpersonal judgements. This researcher sought to determine whether judgements made in the first minute of zero-acquaintance interaction (strangers meeting) are valid predictors of those same judgements made after a longer, more naturalistic conversation. “Thin-slice” literature as well as impression formation literature and some acquaintance process studies seem to support this notion that those judgements made in the first minute will endure over a full-length conversation and that personality judgements may be comparable. Therefore this researcher hypothesizes that: both judgements on companionship and personality will endure from the 1-minute interaction over the longer subsequent 5-minute conversation. This researcher also predicts a weak accuracy of the personality assessment, however that those judgements will endure across conversation periods.
title: Хочу стать врачом! Вводно-фонетический курс русского языка для иностранных студентов
title: Учебно-методическое пособие
titleType: Subtitle
Creators: name: Динес Л.А.
name:  Прокофьева Л.П.
Publisher: name: Ай Пи Эр Медиа
Year: 2019

description: Учебно-методическое пособие является первой частью учебного комплекта для студентов-иностранцев медицинских университетов. Его цель — сформировать первичные языковые знания и речевые навыки, связанные с решением простых коммуникативных задач. Вводно-фонетический курс рассчитан на 80–100 часов аудиторных занятий, из которых 50–60 отводится на обучение устной речи и 10 уроков выстроены с учетом постепенного накопления элементарной грамматики и лексического минимума уровня А1 системы ТРКИ. Для иностранных студентов, начинающих изучать русский язык.
description: Textbook is the first part of a training kit for students of medical universities. His goal is to create primary language knowledge and language skills associated with solving simple communicative tasks. Introductory phonetic course is designed for 80-100 hours of classroom lessons, of which 50-60 are given for teaching oral language and 10 lessons are tailored specifically to the gradual accumulation of basic grammar and lexical minimum of level A1 of the system proper. For foreign students who begin to learn Russian language.
ALMA Imprint of Intergalactic Dark Structures in the Gravitational Lens SDP.81
Creators: name: Inoue, Kaiki Taro
name: Minezaki, Takeo
name: Matsushita, Satoki
name: Chiba, Masashi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present an analysis of the ALMA long baseline science verification data of the gravitational lens system SDP.81. We fit the positions of the brightest clumps at redshift z=3.042 and a possible AGN component of the lensing galaxy at redshift z=0.2999 in the band 7 continuum image using a canonical lens model, a singular isothermal ellipsoid plus an external shear. Then, we measure the ratio of fluxes in some apertures at the source plane where the lensed images are inversely mapped. We find that the aperture flux ratios of band 7 continuum image are perturbed by 10-20 percent with a significance at 2 ~ 3 sigma level. Moreover, we measure the astrometric shifts of multiply lensed images near the caustic using the CO(8-7) line. Using a lens model best-fitted to the band 7 continuum image, we reconstruct the source image of the CO(8-7) line by taking linear combination of inverted quadruply lensed images. At the 50th channel (rest-frame velocity 28.6 km/s) of the CO(8-7) line, we find an imprint of astrometric shifts of the order of 0.01 arcsec in the source image. Based on a semi-analytic calculation, we find that the observed anomalous flux ratios and the astrometric shifts can be explained by intergalactic dark structures in the line of sight. A compensated homogeneous spherical clump with a mean surface mass density of the order of 10^8 solar mass h^-1 arcsec^-2 can explain the observed anomaly and astrometric shifts simultaneously.
description: 17 pages, 16 figures, and 6 tables, version accepted in MNRAS; some minor changes have been made
title: Study of correlation between levator ani muscle injury and pelvic organ prolapse in primiparous women using static and dynamic MRI
Creators: name: Li, Na
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: Pelvis
subject: Genital / Reproductive system female
subject: MR
subject: Outcomes analysis
subject: Pelvic floor dysfunction
subject: Obstetrics
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Evaluate the postpartum changes in levator ani muscle (LAM) using MRI, and the correlation between LAM deficiency and pelvic organ prolapse (POP) in primiparous women post vaginal...
Role of Brain State Switching in System Delays’ Hindrance of Expected System Satisfaction and Dissatisfaction
Creators: name: Harmon, Kevin
name: Walden, Eric
name: Lee, Hansol
name: , Bahar
name: Parmar, Harshit
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Management Information Systems
subject: Social and Behavioral Sciences
subject: information systems
subject: neuroscience

description: System delays are a common cause of unsatisfactory user experience when people interact with information technology. We propose a study to
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
Creators: name: Hoopes, James I.
name: Mieczkowski, Piotr A.
name: Malc, Ewa P.
name: Roberts, Steven A.
name: Mertz, Tony M.
name: Cortez, Luis M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: APOBEC family cytidine deaminases have been recently implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two most probable APOBECs mediating cancer mutagenesis, in a yeast model system. We demonstrate, using mutation reporters and whole genome sequencing, that APOBEC3A- and APOBEC3B-induced mutagenesis primarily results from the deamination of the lagging strand template during DNA replication. Moreover, our results indicate that both genetic deficiencies in replication fork-stabilizing proteins and chemical induction of replication stress greatly augment the mutagenesis of APOBEC3A and 3B. Taken together, these results strongly indicate that ssDNA formed during DNA lagging strand synthesis is a major substrate for APOBECs and may be the principal substrate in human cancers experiencing replication stress.
Impaired autobiographical memory flexibility in Iranian trauma survivors with posttraumatic stress disorder
Creators: name: Hitchcock, Caitlin
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences
subject: Autobiographical memory
subject: PTSD

description: Reduced ability to retrieve specific autobiographical memories is a well-defined feature of posttraumatic stress disorder (PTSD), such that science-driven interventions have emerged to improve memory specificity and thereby symptoms. However, research in depressed samples indicates that the ability to flexibly move between retrieval of specific and general memory types (i.e., memory flexibility) may more accurately conceptualise autobiographical memory deficits in emotional disturbance. This study (N=63) evaluates memory specificity and memory flexibility in Iranian trauma survivors with and without PTSD, relative to community controls. Trauma-exposed participants had experienced a serious road traffic accident. Results indicated that those with PTSD experienced reduced memory specificity and memory flexibility, relative to trauma-exposed and community controls. A small sample size limits the strength of conclusions, although good statistical power was obtained. Findings suggest that reduced memory flexibility may be a transdiagnostic marker of emotional disturbance and support further development of memory flexibility interventions for PTSD.
title: Activity-Based Computation of Marginal Noise Exposure Costs
title: Implications for Traffic Management
titleType: Subtitle
Creators: name: Kaddoura, Ihab
name: Nagel, Kai
Publisher: name: Technische Universität Berlin
Year: 2016
Subjects: subject: 380 Handel, Kommunikation, Verkehr
subject: toll
subject: traffic
subject: noise exposure
subject: traffic control strategy
subject: Berlin

description: In this paper, an innovative simulation-based approach is presented to calculate optimal dynamic, road- and vehicle-specific tolls on the basis of marginal traffic noise exposures. The proposed approach combines the advantages of an activity-based simulation with the economically optimal way of price setting. Temporal and spatial differences of traffic noise levels and population densities are considered. Moreover, noise exposures at work and educational activities are accounted for. The results of a case study for the area of Berlin showed that transport users avoided marginal noise cost payments by shifting to road stretches in areas with lower population densities, typically major roads. The simulation experiments indicated that the marginal cost approach could be used to improve the overall system welfare and to derive traffic control strategies.
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection
Creators: name: Zhang, Shilei
name: Miller, Matthew S.
name: Lin, Xin
name: Zhou, Zhicheng
name: He, Wenqian
name: Wang, Tingting
name: Heise, Mark T.
name: Quan, Yanping
name: Morrison, Clayton
name: Zhao, Xueqiang
name: Jiang, Changying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induce MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively. Here, we found that CARMA3, a scaffold protein previously shown to mediate NF-κB activation induced by GPCR and EGFR, positively regulates MAVS-induced NF-κB activation. However, our data suggest that CARMA3 sequesters MAVS from forming high-molecular weight aggregates, thereby suppressing TBK1/IRF3 activation. Interestingly, following NF-κB activation upon virus infection, CARMA3 is targeted for proteasome-dependent degradation, which releases MAVS to activate IRF3. When challenged with Vesicular stomatitis virus or Influenza A virus, CARMA3-deficient mice showed reduced disease symptoms compared to those of wild type mice due to less inflammation and stronger ability to clear infected virus. Together, our studies reveal the role of CARMA3 in regulating the balance of host anti-viral and pro-inflammatory responses against RNA virus infection.
Integrating CEMDAP and MATSIM to Increase the Transferability of Transport Demand Models
Creators: name: Ziemke, Dominik
name: Nagel, Kai
name: Bhat, Chandra
Publisher: name: Technische Universität Berlin
Year: 2015
Subjects: subject: 380 Handel, Kommunikation, Verkehr
subject: activity-based demand modeling
subject: agent-based simulation
subject: transport modeling
subject: model transferability

description: An activity-based approach to transport demand modeling is considered the most behaviorally sound procedure to assess the effects of transport policies. This paper investigates whether it is possible to transfer an estimated model for activity generation from elsewhere (the estimation context) and use local area (application context) traffic counts to develop a local area activity-based transport demand representation. Here, the estimation context is the Los Angeles, California, area, and the application context is Berlin. Results in this paper suggest that such a transfer approach is feasible, according to a comparison with a Berlin travel survey. Additional studies need to be undertaken to examine the stability of the results obtained in this paper.
title: MRI imaging in Charcot Feet: can imaging findings be accurately used to guide clinical decision-making?
Creators: name: Dening, Jan
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal joint
subject: Musculoskeletal system
subject: MR
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Charcot neuroathropathie is a rare clinical entity with an overall incidence of 0.1-7.5% in the general diabetic population. There is a broad differential and diagnosis is difficult to make and is frequently made in an late or advanced stage of...
title: Individualised CTPA injection protocol optimises contrast use and increases arterial attenuation
Creators: name: Raatschen, Hans-Juergen
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Pulmonary vessels
subject: Lung
subject: Contrast agents
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Embolism / Thrombosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Pulmonary CT angiography has a sensitivity of 90-100% in the detection of pulmonary embolism and is considered the first-line imaging modality in suspected PE [1].However, poor vascular enhancement as well as attenuation artifacts caused by a...
Modeling Location Choice of Secondary Activities with a Social Network of Cooperative Agents
Creators: name: Marchal, Fabrice
name: Nagel, Kai
Publisher: name: Technische Universität Berlin
Year: 2005
Subjects: subject: 380 Handel, Kommunikation, Verkehr
subject: spatial decision
subject: travel behavior
subject: social network
subject: simulation
subject: leisure trips

description: Activity-based models in transportation science focus on the description of human trips and activities. Modeling the spatial decision for so-called secondary activities is addressed in this paper. Given both home and work locations, where do individuals perform activities such as shopping and leisure? Simulation of these decisions using random utility models requires a full enumeration of possible outcomes. For large data sets, it becomes computationally unfeasible because of the combinatorial complexity. To overcome that limitation, a model is proposed in which agents have limited, accurate information about a small subset of the overall spatial environment. Agents are interconnected by a social network through which they can exchange information. This approach has several advantages compared with the explicit simulation of a standard random utility model: (a) it computes plausible choice sets in reasonable computing times, (b) it can be extended easily to integrate further empirical evidence about travel behavior, and (c) it provides a useful framework to study the propagation of any newly available information. This paper emphasizes the computational efficiency of the approach for real-world examples.
Action Effects on Visual Perception of Distances: A Multilevel Bayesian Meta-Analysis
Creators: name: Molto, Lisa
name: Nalborczyk, Ladislas
name: Morgado, Nicolas
name: palluel-germain, richard
Publisher: name: Open Science Framework
Year: 2022

description: Some studies suggested that action constraints influence visual perception of distances. For instance, the greater the effort to cover a distance, the longer people perceive this distance. The present multilevel Bayesian meta-analysis supports the existence of a small action constraint effect on distance estimation, Hedge’s g = 0.29, 95% CrI [0.16, 0.47] (Nstudies = 37, Nparticipants = 1035). This effect slightly varied according to the action constraint category (i.e., effort, weight, and tool-use) but not according to participants’ motor intention. Some authors argued such effects reflect experimental demand biases rather than genuine perceptual effects. Our meta-analysis did not allow to dismiss this possibility, but it did not support it. We provide field-specific conventions for interpreting action constraint effect sizes and minimum sample size to detect them with various levels of power. We encourage researchers to update this meta-analysis using our online repository (https://osf.io/bc3wn/) to send their published or unpublished data. Keywords: perception-action, visual perception, distance perception, meta-analysis, open science **Please, read the README and the associated FAQ to know how to send the data.**
title: Effects of treatments on blood flow values in lung squamous carcinoma and adenocarcinoma assessed with CT perfusion
Creators: name: Baiocco, Serena
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Lung
subject: CT-Quantitative
subject: Treatment effects
subject: Imaging sequences
subject: Multidisciplinary cancer care
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Over the last decade, cancer diagnosis and treatment approaches haveimproved significantly, with the introduction of new therapeutic strategies.Solid tumours are characterised by angiogenesis, a process thatinvolvesthe formation of new vessels from...
Automatic effects of covert practice
Creators: name: Liefooghe, Baptist
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Covert Practice
subject: Liefooghe

description: This contains all materials for de manuscript "Automatic Effects of Covert Practice". Liefooghe, Jim, & De Houwer. QJEP
Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit
Creators: name: Kendra, Alexis M.
name: Whistler, Jennifer L.
name: Yu, Waylin
name: McCall, Nora M.
name: McCall, Jordan G.
name: Hardaway, J. Andrew
name: Al-Hasani, Ream
name: Bloodgood, Daniel W.
name: Kash, Thomas L.
name: Crowley, Nicole A.
name: Lowell, Bradford B.
name: Bruchas, Michael R.
name: Schools, Zachary L.
name: Krashes, Michael J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the stria terminalis (BNST) and occludes the anxiolytic phenotype seen with optogenetic activation of BLA-BNST projections. In addition, deletion of KORs from amygdala neurons results in an anxiolytic phenotype. Furthermore, we identify a frequency-dependent, optically evoked local dynorphin-induced heterosynaptic plasticity of glutamate inputs in the BNST. We also find that there is cell type specificity to the KOR modulation of the BLA-BNST input with greater KOR-mediated inhibition of BLA dynorphin-expressing neurons. Collectively, these results provide support for a model in which local dynorphin release can inhibit an anxiolytic pathway, providing a discrete therapeutic target for the treatment of anxiety disorders.
title: Automated breast volume scanner (ABVS) as alternative method to conventional ultrasound in pre-operative localization of sonographically visible breast cancer
Creators: name: Giuliani, Michela
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Ultrasound
subject: Localisation
subject: Cancer
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast cancer occurs in millions of people all over the worldwith an increasing incidence. American Cancer Society recently reported that the incidence of breast cancer is the highest with a mortality the second among all cancers in the developed...
title: Low-energy laser therapy efficacy assessment by MRI in patients with herniated intravertebral discs
Creators: name: Tkachev, Alexander
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal spine
subject: Neuroradiology spine
subject: MR
subject: Laser
subject: Outcomes analysis
subject: Hernia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Non-surgical (pharmacological) treatment of low back pain in patients with herniated intravertebral disks (glucocorticosteroids, NSAIDs etc) sometimies may be ineffective and last years different interventional technologies are in development...
Critical probability of percolation over bounded region in N-dimensional Euclidean space
Creators: name: Roubin, Emmanuel
name: Colliat, Jean-Baptiste
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Following H. Tomita and C. Murakami we propose an analytical model to predict critical probability of percolation. It is based on the excursion set theory which allows us to consider N-dimensional bounded regions. Details are given for the 3D case and statistically Representative Volume Elements are calculated. Finally generalisation to the N-dimensional case is made.
description: 17 pages, 5 figures, 2 tables, 1 appendix
title: N-Ethoxycarbonylazepine
Creators: name: Hafner, Klaus
name: König, C.
Publisher: name: Wiley
Year: 2023

description: By irradiating a solution of ethyl azidocarbonate in benzene with ultraviolet light, we obtained N-ethoxycarbonylazepine (2) in ca. 70 % yield as a stable yellow oil, b.p. 130°C/20 mm (λmax = 208 mμ (log ε= 4.44) and λmax = 330 mμ(log ε = 2.72) in n-hexane).
Joint modelling of longitudinal and multi-state processes: application to clinical progressions in prostate cancer
Creators: name: Ferrer, Loïc
name: Rondeau, Virginie
name: Dignam, James J.
name: Pickles, Tom
name: Jacqmin-Gadda, Hélène
name: Proust-Lima, Cécile
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Joint modelling of longitudinal and survival data is increasingly used in clinical trials on cancer. In prostate cancer for example, these models permit to account for the link between longitudinal measures of prostate-specific antigen (PSA) and the time of clinical recurrence when studying the risk of relapse. In practice, multiple types of relapse may occur successively. Distinguishing these transitions between health states would allow to evaluate, for example, how PSA trajectory and classical covariates impact the risk of dying after a distant recurrence post-radiotherapy, or to predict the risk of one specific type of clinical recurrence post-radiotherapy, from the PSA history. In this context, we present a joint model for a longitudinal process and a multi-state process which is divided into two sub-models: a linear mixed sub-model for longitudinal data, and a multi-state sub-model with proportional hazards for transition times, both linked by shared random effects. Parameters of this joint multi-state model are estimated within the maximum likelihood framework using an EM algorithm coupled to a quasi-Newton algorithm in case of slow convergence. It is implemented under R, by combining and extending the mstate and JM packages. The estimation program is validated by simulations and applied on pooled data from two cohorts of men with localized prostate cancer and treated by radiotherapy. Thanks to the classical covariates available at baseline and the PSA measurements collected repeatedly during the follow-up, we are able to assess the biomarker's trajectory, define the risks of transitions between health states, and quantify the impact of the PSA dynamics on each transition intensity.
description: Added appendix
Application of machine learning for the extrapolation of seismic data
Creators: name: Nüsse, Amelie Cathrine
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2022

description: Low frequencies in seismic data are often challenging to acquire. Without low frequencies, though, a method like full-waveform inversion might fail due to cycle-skipping. This thesis aims to investigate the potential of neural networks for the task of low-frequency extrapolation to overcome aforementioned problem. Several steps are needed to achieve this goal: First, suitable data for training and testing the network must be found. Second, the data must be pre-processed to condition them for machine learning and efficient application. Third, a specific workflow for the task of low-frequency extrapolation must be designed. Finally, the trained network can be applied to data it has not seen before and compared to reference data. In this work, synthetic data are used for training and evaluation because in such a controlled experiment the target for the network is known. For this purpose, 30 random but geologically plausible subsurface models were generated based on a simplified geology around the Asse II salt mine, and used for finite-difference simulations of seismograms. The corresponding shot gathers were pre-processed by, among others, normalizing them and splitting them up into patches, and fed into a convolutional neural network (U-Net) to assess the network’s performance and its ability to reconstruct the data. Two different approaches were investigated for the task of low-frequency extrapolation. The first approach is based on using only low frequencies as the network’s target, while the second approach has the full bandwidth as target. The latter yielded superior results and was therefore chosen for subsequent applications. Further tests of the network design led to the introduction of ResNet blocks instead of simple convolutions in the U-Net layers, and the use of the mean-absolute-error instead of the mean-squared-error loss function. The final network designed in this way was then applied to the synthetic data originally reserved for testing. It turned out that the chosen method is able to successfully extrapolate low frequencies by more than half an octave (from about 8 to 5 Hz) given the experimental setup at hand. Although the results start to deteriorate in the low-frequency band for larger offsets, full-waveform inversion will overall benefit from the application of the presented machine learning approach.
Adding Mode Choice to Multiagent Transport Simulation
Creators: name: Rieser, Marcel
name: Grether, Dominik
name: Nagel, Kai
Publisher: name: Technische Universität Berlin
Year: 2009
Subjects: subject: 380 Handel, Kommunikation, Verkehr
subject: mode choice
subject: simulation
subject: adaptive scheme
subject: traffic assignment
subject: transport
subject: Zurich

description: It had been shown previously that so-called agent-based traffic micro-simulations could be used for dynamic traffic assignment, that is, iterative route adjustment, until either a Nash equilibrium or some steady state distribution between alternatives had been found. It was also shown that the same approach could be extended to (departure) time adjustment; that is, time adjustment and route adjustment could exist in the same iterative approach. In this paper it is shown that the approach can be extended to mode choice by forcing every synthetic traveler to consider every available mode. The implementation is verified with a test case for which an approximate solution can be analytically derived and for which it is shown that simulation and theory are consistent. It is then applied to a large-scale real-world example, the metropolitan Zurich, Switzerland, area, with about I million inhabitants. For this example, it is shown that the adaptive scheme, albeit seemingly simple, can outperform a more traditional approach that first computes mode choice on the basis of aggregate data and then runs the assignment for car traffic only. Sensitivity tests show that the model reacts in meaningful ways, in particular concerning the interaction between the time structure of activities and mode choice.
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum
Creators: name: Crowther, Andrew J.
name: Deshmukh, Mohanish
name: Sethupathy, Praveen
name: Nakamura, Ayumi
name: Sons, Robert
name: Garcia, Idoia
name: Baran-Gale, Jeanette
name: Gershon, Timothy R.
name: Swahari, Vijay
name: Hammond, Scott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Maintenance of genomic integrity is critical during neurodevelopment, particularly in rapidly dividing cerebellar granule neuronal precursors that experience constitutive replication-associated DNA damage. As Dicer was recently recognized to have an unexpected function in the DNA damage response, we examined whether Dicer was important for preserving genomic integrity in the developing brain. We report that deletion of Dicer in the developing mouse cerebellum resulted in the accumulation of DNA damage leading to cerebellar progenitor degeneration, which was rescued with p53 deficiency; deletion of DGCR8 also resulted in similar DNA damage and cerebellar degeneration. Dicer deficiency also resulted in DNA damage and death in other rapidly dividing cells including embryonic stem cells and the malignant cerebellar progenitors in a mouse model of medulloblastoma. Together, these results identify an essential function of Dicer in resolving the spontaneous DNA damage that occurs during the rapid proliferation of developmental progenitors and malignant cells.
Christmas cards: are senders full of joy and good cheer?
Creators: name: GALLAGHER, STEPHEN
name: Howard, Siobhan
name: McMahon, Jennifer
name: Palmieri, Carlos
Publisher: name: University of Limerick
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology

description: People with depression often struggle with Christmas. The festive period is often associated with parties, social engagement, putting up Christmas trees among other behaviours. Here, in a large UK population level dataset, we examine whether higher depressive symptomatology was associated with frequency of sending Christmas cards, and if this varied by religious affiliation. Retrospective observational study. Participants were 2,416 individuals within the UK who completed data from 2013 to 2015 within Wave 5 of the longitudinal survey ‘Understanding Society’. Data on depressive symptoms 12-General Health Questionnaire, frequency of sending Christmas cards, and religious affiliation were extracted. A higher percentage (54.5%) of those without depressive symptoms reported ‘Always’ sending Christmas cards, compared to 46.0% of those with depressive symptoms χ2 (2) = 8.71, p < .001. After adjusting for religious affiliation, this remained significant only for Christians after holding, gender, relationship status and ethnicity constant. Christians with depression (20%) were more likely to ‘Never’ send Christmas cards, while those not depressed were 53% more likely to ‘Always’ send them, p < .01. In those identifying as Christians not sending a Christmas card was significantly associated with depressive symptoms. This might help provide a way to identify loved ones, friends or colleagues who may need help and support at Christmas.
Assessment Tools for Early Mathematical Development: A Systematic Review
Creators: name: Outhwaite, Laura
name: Van Herwegen, Jo
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Educational Methods
subject: Educational Psychology
subject: Developmental Psychology
subject: Education
subject: Child Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Educational Assessment, Evaluation, and Research
subject: Early Childhood Education

description: To support the development of intervention and longitudinal studies in mathematical learning and development, there is a need to synthesise the assessment tools currently available that can appropriately measure children’s mathematical skills in early childhood (0-8 years). In response, this systematic review will identify and catalogue assessment tools, including direct assessments, observation checklists, and teacher/parent questionnaires for early mathematical skills. The psychometric properties (i.e., reliability and validity) and practical considerations for each assessment tool will be examined.
title: Myeloma bone lesions on whole-body diffusion-weighted MRI at 3.0 T: characterisation and comparison of ADC and b1000 value on two different MRI platforms of the same vendor
Creators: name: Pans, Steven
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Haematologic
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Haematologic diseases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) is a recent functional imaging technique used for staging and response assessment in oncology. WB-DW-MRI depends on microscopic water molecule mobility and can be quantified using...
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication
Creators: name: Nio, Kouki
name: Reszka-Blanco, Natalia
name: Su, Lishan
name: Murphy, Christopher M.
name: Xu, Yanping
name: Li, Feng
name: Li, Xiaodong
name: Wu, Yaxu
name: Yu, Yanbao
name: Xiong, Yue
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural maintenance of chromosomes (SMC) complex proteins SMC5 and SMC6 as CRL4(HBx) substrates. HBx expression and HBV infection degraded the SMC5/6 complex in human hepatocytes in vitro and in humanized mice in vivo. HBx targets SMC5/6 for ubiquitylation by the CRL4(HBx) E3 ligase and subsequent degradation by the proteasome. Using a minicircle HBV (mcHBV) reporter system with HBx-dependent activity, we demonstrate that SMC5/6 knockdown, or inhibition with a dominant-negative SMC6, enhance HBx null mcHBV-Gluc gene expression. Furthermore, SMC5/6 knockdown rescued HBx-deficient HBV replication in human hepatocytes. These results indicate that a primary function of HBx is to degrade SMC5/6, which restricts HBV replication by inhibiting HBV gene expression.
Scaling of alloy interfacial properties under compositional strain
Creators: name: Huang, Zhi-Feng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Complex morphologies and microstructures that emerge during materials growth and solidification are often determined by both equilibrium and kinetic properties of the interface and their crystalline anisotropies. However limited knowledge is available for the alloying and particularly the compositionally generated elastic effects on these interface characteristics. Here we systematically investigate such compositional effects on the interfacial properties of an alloy model system based on the phase-field-crystal analysis, including the solid-liquid interfacial free energy, kinetic coefficient, and lattice pinning strength. Scaling relations for these interfacial quantities over various ranges of material parameters are identified and predicted. Our results indicate the important effects of couplings among mesoscopic and microscopic length scales of alloy structure and concentration, and also the influence of compressive and tensile interface stresses induced by composition variations. The approach developed here provides an efficient way to systematically identify these key material properties beyond the traditional atomistic and continuum methods.
description: 13 pages, 14 figures; Phys. Rev. E, in press
title: Carotid artery MR-image analysis: efficacy of an educational module
Creators: name: Maraj, Tishan
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiovascular system
subject: Head and neck
subject: Vascular
subject: MR
subject: Observer performance
subject: Segmentation
subject: Computer Applications-Detection, diagnosis
subject: Education and training
subject: Arteriosclerosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Carotid artery atherosclerosis is related to cerebrovascular disease[1,2]. Strokes are the 2 nd leading cause of mortality worldwide with the ischemic type predominating[3,4]. Risk of event occurrence can be determined using wall thickness, as with...
title: Computed tomography in the differential diagnosis of malignant and benign lesions in maxilla
Creators: name: Yuan, Ying
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Head and neck
subject: CT
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Our aim was to identify the computed tomographic (CT) characteristics most useful to differentiate malignant maxillary tumors (MMTs) from benign maxillary lesions...
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase
Creators: name: Espinosa, Joaquin M.
name: Strahl, Brian D.
name: Andrews, Forest H.
name: Guo, Angela H.
name: Tong, Qiong
name: Ahn, JaeWoo
name: Rothbart, Scott B.
name: Sullivan, Kelly D.
name: Kutateladze, Tatiana G.
name: Pandey, Ahway
name: Ali, Muzaffar
name: Costello, James C.
name: Zhang, Yi
name: Cornett, Evan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: MORC3 is linked to inflammatory myopathies and cancer; however, the precise role of MORC3 in normal cell physiology and disease remains poorly understood. Here, we present detailed genetic, biochemical, and structural analyses of MORC3. We demonstrate that MORC3 is significantly upregulated in Down syndrome and that genetic abnormalities in MORC3 are associated with cancer. The CW domain of MORC3 binds to the methylated histone H3K4 tail, and this interaction is essential for recruitment of MORC3 to chromatin and accumulation in nuclear bodies. We show that MORC3 possesses intrinsic ATPase activity that requires DNA, but it is negatively regulated by the CW domain, which interacts with the ATPase domain. Natively linked CW impedes binding of the ATPase domain to DNA, resulting in a decrease in the DNA-stimulated enzymatic activity. Collectively, our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease.
title: Selective internal radiation therapy Y90 (SIRT) in multifocal intrahepatic cholangiocarcinoma (ICC): clinic preliminary results
Creators: name: Valente, Iacopo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional vascular
subject: Oncology
subject: Nuclear medicine
subject: Catheter arteriography
subject: CT
subject: Radionuclide therapy
subject: Radiation therapy / Oncology
subject: Embolisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignant tumor after HCC; it accounts for 10–20% of all primary liver cancers [1]. The incidence of ICC has been increasing worldwide. ICC are often asymptomatic and...
title: Changes in brain signal intensity after intravenous injections of 0.075 mmol/kg of gadobenate dimeglumine: a retrospective evaluation of 112 patients
Creators: name: Doniselli, Fabio
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Contrast agents
subject: Neuroradiology brain
subject: MR
subject: Contrast agent-intravenous

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Introduction Gadolinium (Gd) isused as contrast agents in magnetic resonance imaging (MRI) since 1989. Due to its high toxic effects on biological tissues [1], chelant molecule is necessary to bind Gd ion and preventing its relapsing in human...
title: Paediatric CTA: nephrotoxic complications in high concentration iodinated contrast medium administration in children with congenital heart disease
Creators: name: Clemente, Alberto
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Paediatric
subject: Cardiovascular system
subject: Contrast agents
subject: CT-Angiography
subject: Computer Applications-Detection, diagnosis
subject: Toxicity
subject: Congenital

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Iodinated contrast media (CM) has been used for a long time in conjunction with x-ray procedures as a diagnostic tool, and CM nephrotoxicity is well established since 1955, with many reported studies regarding this complication in the medical...
Measurement of the production of neighbouring jets in lead-lead collisions at $\sqrt{s_{\mathrm{NN}}} = 2.76$ TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: This Letter presents measurements of correlated production of nearby jets in Pb+Pb collisions at $\sqrt{s_{\mathrm{NN}}} = 2.76$ TeV using the ATLAS detector at the Large Hadron Collider. The measurement was performed using 0.14 ${\rm nb}^{-1}$ of data recorded in 2011. The production of correlated jet pairs was quantified using the rate, $R_{ΔR}$, of "neighbouring" jets that accompany "test" jets within a given range of angular distance, $ΔR$, in the pseudorapidity--azimuthal angle plane. The jets were measured in the ATLAS calorimeter and were reconstructed using the anti-$k_{t}$ algorithm with radius parameters $d = 0.2$, $0.3$, and $0.4$. $R_{ΔR}$ was measured in different Pb+Pb collision centrality bins, characterized by the total transverse energy measured in the forward calorimeters. A centrality dependence of $R_{ΔR}$ is observed for all three jet radii with $R_{ΔR}$ found to be lower in central collisions than in peripheral collisions. The ratios formed by the $R_{ΔR}$ values in different centrality bins and the values in the 40-80 % centrality bin are presented.
description: 12 pages plus author list + cover pages (28 pages total), 6 figures, 2 tables, submitted to Physics Letters B, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2013-10/
title: Einfache Ringerweiterung des Azulens zum Cyclopentacyclononen-System durch dipolare Cycloaddition
Creators: name: Hafner, Klaus
name: Lindner, Hans Jörg
name: Ude, Werner
Publisher: name: Wiley
Year: 2023

description: Das Cyclopentacyclononen-Derivat (3), die erste Verbindung mit diesem Ringsystem und zugleich das erste stabile Cyclononatetraen ohne anellierten Benzolring, wurde aus dem „Ethano-azulen”︁ (1) synthetisiert. Dieser Erfolg ist der Beobachtung zu verdanken, daß Azulen leicht mit dem Inamin (2) reagiert, und zwar zum Tricyclus (4). 4, 6, 8-Trimethylazulen ergibt zwar das gewünschte Ringsystem (5), doch schnürt es sich sofort ab. Die Klammern in (1) verhindert diese Reaktion.
title: Predicting the real volume of liver metastases from diameter-based measurements and the lesions’ shape
Creators: name: Hofmann, Felix
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Liver
subject: CT-Quantitative
subject: Segmentation
subject: Diagnostic procedure
subject: Metastases
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: RECIST [1] has got limitations [2-4], such as unidimensional measurements of solid tumour lesions are used as a surrogate markers for the tumour volume. Lesions are usually not perfectly spherical in shape [5]. Thus unidimensional measurements may...
title: Rotator cable imaging with a low field MRI sectorial unit: morphological findings and pathological considerations
Creators: name: Ottonello, Carlo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal joint
subject: MR
subject: Diagnostic procedure
subject: Athletic injuries
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To study the rotator cable (RC) using a low field MRI sectorial unit and to correlate morphological RC findings with rotator cuff...