cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spectro-temporal Receptive Fields Constructed on Neuronal Input and Output in the Auditory Cortex
Creators: name: Bao, Xiaohan
Publisher: name: Graduate Studies
Year: 2017
Subjects: Neuroscience

description: Frequency coding is a principal function of the auditory system. Frequency selectivity and level tolerances are reflected by the sharpness of frequency tuning, often quantified as frequency bandwidths. Along the ascending auditory pathway, spectral information of complex acoustic stimuli is progressively decomposed with higher-level subcortical nuclei evincing more sharply-tuned neurons. Auditory cortical neurons feature broad variation in bandwidths, due to convergent thalamocortical projections. Oppositely, cortical modulation characterized by input and output frequency receptive fields most likely acts by sharpening frequency tuning. Spectro-temporal receptive fields (STRFs) constructed on post-synaptic potential (PSP) amplitude and action potential (AP) firing rates were recorded from mouse auditory cortex layer IV neurons using in vivo whole-cell current-clamp without blocking voltage-dependent conductances. AP-based STRFs showed smaller bandwidths than PSP-based STRFs while frequency bandwidths increased with sound level using multi-frequency stimuli, but less so using single-frequency stimuli. Bandwidth ratios of PSP- and AP-based STRFs were reduced by raising sound level or stimulus density.
Η ανθρώπινη αναβάθμιση και το πρόταγμα της αθανασίας: ηθικά και πολιτικά ζητήματα
Creators: name: Τορνικίδου, Σοφία Χαράλαμπου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Υπερανθρωπισμός
Κοσμισμός
Αθανασία
Transhumanism
Cosmism
Immortality

description: Στόχος της εργασίας είναι αφενός να δείξει την πορεία που ακολούθησε η ανθρώπινη αυτοκατανόηση, παρακολουθώντας πώς το ανθρωπιστικό ρεύμα, αναζητώντας την αναβάθμιση, εξελίχθηκε σε υπερανθρωπιστικό, και αφετέρου να δείξει πώς τα ρεύματα του υπερανθρωπισμού γενικότερα εξελίσσονται στον πολιτικό χώρο προσπαθώντας να ξεπεράσουν το δίπολο αριστερά και δεξιά και να περάσουν σε μία νέα εποχή ουδετεροποίησης και αποπολιτικοποίησης μέσω της τεχνολογίας, χαράσσοντας έναν «τρίτο δρόμο». Για να καταστεί αυτό δυνατό, στο πρώτο μέρος της εργασίας γίνεται ανασκόπηση των όρων «ανθρωπισμός», «υπερανθρωπισμός», «μετανθρωπισμός» και «κοσμισμός» και στο δεύτερο μέρος εξετάζεται το πώς οι παραπάνω κοσμοθεωρίες έχουν επηρεάσει την πολιτική σκηνή από τον 19ο αι. και έπειτα. Η εκπόνηση της παρούσας εργασίας δεν αποτελεί ούτε απόρριψη ούτε υπεράσπιση των υπερανθρωπιστικών προταγμάτων, παρά μία προσπάθεια να διαφωτιστούν και να εξεταστούν σκεπτικιστικά ορισμένες πτυχές τους, κυρίως από την σκοπιά των ηθικών και πολιτικών διλημμάτων που προκύπτουν.
description: The aim of the paper is, on the one hand, to show the course followed by human self-understanding, observing how the humanist current, in search of upgrading, evolved into a transhumanist one, and on the other hand, to show how the currents of transhumanism in general evolve in the political space, trying to overcome the political dipole of left and right Wing and move into a new era of neutralization and depoliticization through technology, charting a "third way". To make this possible, the first part of the paper reviews the terms "humanism", "posthumanism", "transhumanism" and "cosmism" and the second part examines how the above worldviews have influenced the political scene from the 19th century onwards. The preparation of this work is neither a rejection nor a defense of the transhumanist projects, but rather an attempt to enlighten and sceptically examine certain aspects of them, mainly from the point of view of the moral and political dilemmas that arise.
Phenomenology of the CAH+ measure
Creators: name: Salem, Michael P.
name: Vilenkin, Alexander
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The CAH+ measure regulates the infinite spacetime volume of the multiverse by constructing a surface of constant comoving apparent horizon (CAH) and then removing the future lightcones of all points on that surface (the latter prescription is referred to by the "+" in the name of the measure). This measure was motivated by the conjectured duality between the bulk of the multiverse and its future infinity and by the causality condition, requiring that the cutoff surfaces of the measure should be spacelike or null. Here we investigate the phenomenology of the CAH+ measure and find that it does not suffer from any known pathologies. The distribution for the cosmological constant Lambda derived from this measure is in a good agreement with the observed value, and the distribution for the number of inflationary e-foldings satisfies the observational constraint. The CAH+ measure does not exhibit any "runaway" behaviors at zero or negative values of Lambda, which have been recently shown to afflict a number of other measures.
description: 35 pages, including 6 figures and 2 appendices; v2 corrections in Section 2.4, conclusions unchanged
Influences of grazing and landscape on bee pollinators and their floral resources in rough fescue prairie
Creators: name: Evans, Megan
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: flowers
subject: pollinators
subject: grazing
subject: Landscape
subject: mutualistic networks
subject: Specialization

description: Studies of the effects of cattle grazing on bees show conflicting results. I used two approaches to evaluate these effects in the rough fescue grasslands of Southern Alberta. First, using Structural Equation Models, I evaluated how grazing, landscape and flowers affected bees. I found that grazing directly affected flowers (not bees), flowers only affected bees weakly, and landscape was more important than grazing in explaining bee assemblages. Second, I analyzed mutualistic networks to evaluate the effects of grazing on the relationship between bees and flowers. Grazing affected both bees and flowers. Specialization (H2’) was lower in heavily grazed fields, suggesting stronger effects of grazing disturbance on specialists than on generalists. Overall, landscape composition seems more relevant to managing land for pollination services, but grazing is important to consider for conservation of rare and/or specialized bees and plants.
The Presence of Baseline HBsAb-Specific B Cells Can Predict HBsAg or HBeAg seroconversion of Chronic Hepatitis B on treatment
Creators: name: Yin, Shengxia
name: Wan, Yawen
name: Issa, Rahma
name: Zhu, Yijia
name: Xu, Xiaoming
name: Liu, Jiacheng
name: Mao, Minxin
name: Li, Ming
name: Tong, Xin
name: Tian, Chen
name: Wang, Jian
name: Huang, Rui
name: Zhang, Qun
name: Wu, Chao
name: Chen, Yuxin
name: Li, Jie
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Indices for predicting HBsAg or HBeAg seroconversion in patients with chronic hepatitis B virus (HBV) infection during antiviral therapy remain elusive. We aimed to investigate if the presence of HBsAb-specific B cells at baseline can predict HBsAg or HBeAg seroconversion in patients with chronic HBV being treated with peg-IFN-α or nucleotide analogues (NAs). 134 treatment-naive patients with chronic HBV were enrolled in the study. We collected peripheral blood mononuclear cells (PBMCs) from all patients and performed a baseline HBsAb-specific B cell ELISpot assay. Serum samples were collected at 12 weeks, 24 weeks, and 48 weeks for patients treated with Peg-IFN-α, or at 1 year, 3 years, and 5 years for patients treated with NAs. Laboratory testing of HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HBV DNA, ALT, and AST was done. The role of baseline HBsAb-specific B cells in predicting HBsAg seroconversion in patients treated with peg-IFN-α and HBeAg seroconversion in patients treated with NAs was analyzed. Logistic regression was used to analyze influential factors for HBsAg seroconversion in patients on Peg-IFN-α treatment. We observed a significantly lower frequency of HBsAb-specific B cells in patients with chronic HBV than in healthy individuals (4.16 vs. 44.78 cells per 106 PBMCs). In the Peg-IFN-α-treated group, 41.2% (14 out of 34) of patients with baseline HBsAb-specific B cells achieved HBsAg seroconversion, while only 13.6% (6 out of 44) of patients without baseline HBsAb-specific B cells achieved HBsAg seroconversion (P = 0.006). By logistic regression analysis, patients with baseline HBsAb-specific B cells and HBsAg ≤ 1500 had higher HBsAg clearance at the end of treatment (P < 0.05). In the NA-treated group, 58.3% (7 out of 12) of patients with baseline HBsAb-specific B cells achieved HBeAg seroconversion, whereas only 30.0% (6 out of 20) of patients without baseline HBsAb-specific B cells achieved HBeAg seroconversion (P = 0.114). Baseline HBsAb-specific B cells by ELISpot assay might be a valuable predictive biomarker of HBsAg or HBeAg seroconversion in patients with chronic HBV.
On the fate of the phantom dark energy universe in semiclassical gravity II: Scalar phantom fields
Creators: name: de Haro, Jaume
name: Amoros, Jaume
name: Elizalde, Emilio
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Quantum corrections coming from massless fields conformally coupled with gravity are studied, in order to see if they can lead to avoidance of the annoying Big Rip singularity which shows up in a flat Friedmann-Robertson-Walker universe filled with dark energy and modeled by a scalar phantom field. The dynamics of the model are discussed for all values of the two parameters, named $α>0$ and $β<0$, corresponding to the regularization process. The new results are compared with the ones obtained in \cite{hae11} previously, where dark energy was modeled by means of a phantom fluid with equation of state $P=ωρ$, with $ω
Managing relationships and developing sustainability : the case of VANOC and the Vancouver 2010 national partners
Creators: name: Yang, Xinquan
Publisher: name: University of British Columbia
Year: 2011

description: The purpose of this study was to investigate how corporate sponsorship might contribute to Olympic sustainability, including economic, environmental and social sustainability. The research focused on the partnership management strategies of VANOC (the Vancouver 2010 Olympic and Paralympic Winter Games Organizing Committee) and the six national Vancouver 2010 corporate partners, with an emphasis on the role of social responsibility imperatives in shaping corporate investments in the sustainability of the Vancouver 2010 Games. The research followed an interpretive approach. My research focused on how decision-makers endeavored to reduce the potentially negative impacts and to enhance the benefits of the Vancouver 2010 Games. The research followed a case study approach focusing on the key relationships formed in the sustainability area. Data collection included document analysis (128 documents) and semi-structured interviews with 26 key informants identified by VANOC and the corporate partners. The results of the study show that VANOC was the first OCOG to fully integrate sustainability into its vision statement and to apply sustainability principles in all aspects of Games’ planning, operations and delivery. These measures were a direct response to the Vancouver 2010 bid commitments, as well as a response to the IOC’s (International Olympic Committee’s) adoption of sustainability, along with sport and culture, as a central element of the philosophy of the Olympic Movement. Although the motivations for corporations to enter Olympic sponsorship were typically not for sustainability objectives as such, they considered sustainability a key component in forming the Olympic partnership. Sponsorship activation on sustainability for the corporate partners was aided through the 2010 Sponsor Sustainability Initiative and 2010 Legacies Now. For the most part, the corporate partners were very satisfied with their role in contributing to the sustainability of the Games and with VANOC’s management strategies. Nevertheless, a few areas of tension were identified. One was that VANOC did not have an activation budget for promoting the sustainability program and the contributions of the partners to the sustainability of the Games. The other key point of tension occurred when VANOC sought assistance in areas that were outside of their corporate expertise or core business interest.
Exchange-induced phase separation in Ni-Cu films
Creators: name: Kravets, Anatolii
name: Timoshevskii, Andrey
name: Yanchitsky, Bogdan
name: Salyuk, Olga
name: Yablonovskii, Sergey
name: Andersson, Sebastian
name: Korenivski, Vlad
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Magneto-structural properties of films of diluted ferromagnetic alloys Ni$_x$Cu$_{1-x}$ in the concentration range $0.7 < x < 1.0$ are studied experimentally. Films deposited by magnetron sputtering show partial phase separation, as evidenced by structural analysis and ferromagnetic resonance measurements. The phase diagram of the Ni$_x$Cu$_{1-x}$ bulk system is obtained using numerical theoretical analysis of the electronic structure, taking into account the inter-atomic exchange interactions. The results confirm the experimentally found partial phase separation, explain it as magnetic in origin, and indicate an additional metastable region connected with the ferromagnetic transition in the system.
description: 5 pages, 6 figures
Longitudinal Analysis and Modeling of Video Game Play and Addiction Behaviours
Creators: name: Wong, Ulric
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Psychology--Behavioral
subject: Psychology--Clinical
subject: Psychology--Social
subject: Internet gaming disorder
subject: video game
subject: Addiction
subject: problem video game play
subject: mixed effects model
subject: Longitudinal
subject: repeated measures
subject: hierarchical linear model
subject: growth curve

description: This longitudinal study examined Internet gaming by measuring number of days played per month of a massively multiplayer online role playing game (MMORPG), World of Warcraft (WoW), collected daily for 19 months from 216 participants. This study was an attempt to improve our understanding of long term play of a purportedly addictive game using behavioural rather than self-reports measures alone. Participants also completed online questionnaires that measured demographic, psychosocial and psychiatric variables at three time points during the study. The data was modeled using (a) cross-sectional models and (b) longitudinal models fitted to the entire participant pool and to a subset of higher use participants. The longitudinal growth curve model fitted to the complete pool of participants suggested that monthly WoW days played was related to higher income, more self-reported days playing video games per week, increasing GAIA coping subscale scores, play of a new WoW expansion pack, and higher ranking of WoW among participants‘ favourite games. The longitudinal growth curve model fitted to a subset of participants in the top 75th percentile of total days played suggested that monthly WoW days played was explained by older age, part time student status, expansion pack play, and higher ranking of WoW among participants‘ favourite games. Higher baseline GAIA addiction scores predicted higher monthly WoW days. Unexpectedly, increasing GAIA addiction scores and GAIA coping scores were related to decreasing monthly WoW days played in this subset of participants. Compared to the cross-sectional models, the longitudinal growth curve models allowed for the modeling of autocorrelated observations and play as a series of exposure and adaptation effects, likely in response to new content. The GAIA coping subscale had a robust relationship with WoW play across high and low use participants while the effects of the GAIA addiction full scale were only significant when the bottom 25% of participants by total WoW days played were excluded from the analysis. Results from the cross-sectional and longitudinal models may have implications for assessment and treatment in clinical settings.
Antecedentes de trauma infantil y salud mental
Creators: name: Blasco Garrido, Andrea
name: Mateos Agut, Manuel
name: Osorio Guzman, Ángela
name: Abadín Vázquez, Matilde
name: Sanz Cid, Beatriz
name: De La Gándara Martín, Jesús José
name: Alvela Fernández, Sonia
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Más allá de la paradoja del insight en la psicosis: la autorreflexión modera el efecto de la depresión sobre el malestar psicológico en personas con psicosis
Creators: name: García Mieres, Helena
name: De Jesús-Romero, Robinson
name: Ochoa, Susana
name: Feixas, Guillem
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Improving regulator verification and compact representations in real quadratic fields
Creators: name: Silvester, Alan
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Mathematics
subject: FOS: Mathematics

description: The study of Diophantine equations, and in particular the erroneously-named Pell equation, has a long and intriguing history. In this work, we investigate solutions to the Pell equation and to a closely related quantity called the fundamental unit. Though it is somewhat simple to show these equations have non-trivial solutions, finding unconditionally correct solutions and being able to express them is extremely challenging, both from a theoretical and a computational perspective. We develop improvements to the algorithm presented by de Haan, Jacobson, and Williams [21, 22] which unconditionally verifies the regulator of a real quadratic number field and refinements to the concept of a compact representation of a quadratic integer, originally given by Buchmann, Thiel, and Williams [12]. In addition, we consider the well-known applications of this theory to principal ideal testing, finding integer points on elliptic curves, finding solutions to Diophantine equations, and some particular cryptographic applications.
ROPS: A New Search for Habitable Earths in the Southern Sky
Creators: name: Barnes, J. R.
name: Jenkins, J. S.
name: Jones, H. R. A.
name: Rojo, P.
name: Arriagada, P.
name: Jordan, A.
name: Minniti, D.
name: Tuomi, M.
name: Jeffers, S. V.
name: Pinfield, D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the first results from our Red Optical Planet Survey (ROPS) to search for low mass planets orbiting late type dwarfs (M5.5V - M9V) in their habitable zones (HZ). Our observations, with the red arm of the MIKE spectrograph (0.5 - 0.9 microns) at the 6.5 m Magellan Clay telescope at Las Campanas Observatory indicate that >= 92 per cent of the flux lies beyond 0.7 microns. We use a novel approach that is essentially a hybrid of the simultaneous iodine and ThAr methods for determining precision radial velocities. We apply least squares deconvolution to obtain a single high S/N ratio stellar line for each spectrum and cross correlate against the simultaneously observed telluric line profile, which we derive in the same way. Utilising the 0.62 - 0.90 micron region, we have achieved an r.m.s. precision of 10 m/s for an M5.5V spectral type star with spectral S/N ~160 on 5 minute timescales. By M8V spectral type, a precision of ~30 m/s at S/N = 25 is suggested, although more observations are needed. An assessment of our errors and scatter in the radial velocity points hints at the presence of stellar radial velocity variations. Of our sample of 7 stars, 2 show radial velocity signals at 6-sigma and 10-sigma of the cross correlation uncertainties. If the signals are planetary in origin, our findings are consistent with estimates of Neptune mass planets that predict a frequency of 13 - 27 per cent for early M dwarfs.Our current analysis indicates the we can achieve a sensitivity that is equivalent to the amplitude induced by a 6 M_Earth planet orbiting in the habitable zone. Based on simulations, we estimate that <10 M_Earth habitable zone planets will be detected in a new stellar mass regime, with <=20 epochs of observations.
description: MNRAS accepted: 14 pages, 8 figures, 3 tables
Βελτιστοποίηση Σμήνους Σωματιδίων: Εφαρμογή Οπτικοποίησης
Creators: name: Μάζνης, Ευθύμιος Δημητρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Βελτιστοποίηση σμήνους σωματιδίων
Νοημοσύνη σμήνους
Αλγόριθμοι εμπνευσμένοι από τη βιολογία
Στοχαστικοί αλγόριθμοι
Βελτιστοποίηση
Οπτικοποίηση αλγορίθμων
Συναρτήσεις δοκιμής
Particle swarm optimization
Swarm intelligence
Bio-inspired algorithms
Stochastic algorithms
Optimization
Algorithm visualization
Benchmark functions

description: Παρουσιάζεται μια νέα εφαρμογή που μπορεί να χρησιμοποιηθεί για να απεικονίσει την εκτέλεση διαφορετικών παραλλαγών Βελτιστοποίησης Σμήνους Σωματιδίων (Particle Swarm Optimization - PSO). Από την εισαγωγή του το 1995, ο πρώτος αλγόριθμος PSO έχει δεχθεί διάφορες βελτιώσεις, οι οποίες είναι επίσης επιδείξιμες, χάρη στις δυνατότητες ρύθμισης των παραμέτρων των αλγορίθμων, που προσφέρει η εφαρμογή. Πέραν της δυνατότητας παρουσίασης της συμπεριφοράς αυτών των αλγορίθμων και σύγκρισής τους, παρέχεται και μια σαφής απεικόνιση του τρόπου με τον οποίο οι τιμές των παραμέτρων μπορούν να επηρεάσουν την απόδοσή του. Έχουν υλοποιηθεί διαφορετικές συναρτήσεις δοκιμής με τα ιδιαίτερα χαρακτηριστικά τους, καθώς και επιλογές για τοπολογίες και οριακές συνθήκες, ώστε να παρέχεται μια ακόμα βαθύτερη κατανόηση του τρόπου με τον οποίο τα σωματίδια ενεργούν σε διαφορετικά σενάρια. Ως εργαλείο, η εφαρμογή προσωπικού υπολογιστή μπορεί να αποδειχθεί πολύ χρήσιμη για τη διδασκαλία φοιτητών και ερευνητών, καθώς δύνανται να εξερευνήσουν αμέτρητους συνδυασμούς, καθιστώντας τους τελικά πιο ικανούς να αντιμετωπίσουν προβλήματα του πραγματικού κόσμου.
description: A novel application that can be used to visualize the execution of different Particle Swarm Optimization (PSO) variants is presented. Since its introduction in 1995, the original PSO algorithm itself has received various improvements, which are also demonstrable, thanks to the application’s parameter tweaking capabilities, for the algorithms. The application offers the ability to showcase the behavior of these algorithms and compare them, while also providing a clear visualization of how parameter values can impact its performance. Different benchmark functions with their distinct characteristics, along with options for topologies and boundary conditions, have been implemented, to provide an even deeper understanding of the way the particles act in different scenarios. As a tool, the desktop app can prove to be very useful for teaching students and researchers, as they can explore endless combinations, ultimately rendering them more capable of tackling real world problems.
Atenciones en urgencias psiquiátricas e intentos de suicidio antes y durante el estado de alarma en la provincia de Lérida
Creators: name: Irigoyen, María
name: Porras, Alejandro
name: Agraz, Marc
name: Arenas, Laura
name: Sánchez, Marta
name: Torterolo, Giovanni
name: Fuentes, Deborah
name: Puigdevall, Margarita
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Geochemical Characterization of the Second White Speckled Shale Formation, Western Canada Sedimentary Basin and the Mass Fraction Maturity Defining Thermal Maturity Level
Creators: name: Ma, Jingping
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: maturity
subject: source rock
subject: SWS
subject: mass fraction
subject: absolute concentration

description: Source rocks with database of maturity variation from the Second White Speckled Shale Formation (SWS) were characterized geochemically by traditional source-related and maturity parameters. The changes of absolute concentrations with increasing thermal maturity was concluded. Biomarkers are initially generated and concentrated at immature to low mature stages during diagenesis, then their concentrations decrease dramatically with increasing maturity during catagenesis. n-Alkanes, especially light n-alkanes, are generated from kerogen thermal cracking and their concentrations increase continuously with thermal maturity in the whole oil generation window. Most polycyclic aromatic hydrocarbons are generated at early oil window to peak oil generation then destroyed at post mature stage. It is uncontroversial that crude oils are mixtures of different components charged from source rocks at different temperatures. Traditional thermal maturity parameters are unreliable when tracking maturities of crude oils. Combining absolute concentration profiles, mass fraction maturity model is mentioned for assessing maturity of crude oils.
OILA PSIXOLOGIYASI
Creators: name: Yo'ldashova, Marjona
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada oila psixologiyasining ahamiyati, uning asosiy tamoyillari va oilaviy munosabatlarning inson ruhiyatiga ta’siri tahlil qilinadi. Muallif oilaviy muhitning shaxsiy rivojlanishga, psixologik barqarorlikka va ijtimoiy moslashuvga ta’sirini yoritib beradi. Shuningdek, maqolada oilaviy nizolar, ularning kelib chiqish sabablari va ularni hal etish yo ‘llari muhokama qilinadi. Tadqiqot natijalari asosida oilaviy munosabatarni yaxshilashga qaratilgan tavsiyalar beriladi.
The Effect of Myostatin on Glucose Metabolism and Insulin Sensitivity
Creators: name: Ghozlan, Mostafa
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Biology--Molecular
subject: Biochemistry
subject: Myostatin
subject: Glucose
subject: Insulin
subject: Sensitivity
subject: Muscle
subject: Liver
subject: Glycogen
subject: Mitochondria
subject: Respirometry
subject: Metabolism

description: Aim : Myostatin (MSTN) is a negative regulator of skeletal muscle proliferation and differentiation that we previously associated with insulin resistance in humans and mice. We assessed its potential regulatory role in glucose metabolism and insulin sensitivity in vivo and in vitro. Methods: Using various approaches we assessed the following parameters: in vivo GTT and ITT and in vitro insulin-stimulated glucose uptake for insulin sensitivity, qRT-PCR for Glut1, Glut4, Gyg1, Hk2, IL-6, Western blotting for protein levels of AMPK and ACC and high-resolution respirometry for glucose-dependent mitochondrial respiration. Results: MSTN showed significant reduction of hepatic insulin-stimulated glucose uptake in vitro and reduced glycogen content in vivo without affecting glycolysis, glucose metabolism genes, AMPK signalling or mitochondrial respiration. Conclusion: This study presents evidence for the potential role of liver in MSTN-induced insulin resistance; especially glucose uptake and glycogen content, which necessitates further investigation of the role of MSTN in this metabolically critical organ.
Cerebellar Model Articulation Controllers for Bilateral Teleoperation with Elastic-Joint Manipulators and Haptic Feedback
Creators: name: L'Orsa, Rachael
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Engineering--Electronics and Electrical
subject: Engineering--Mechanical
subject: Robotics
subject: teleoperation
subject: Haptics
subject: Cerebellar Model Articulation Controller
subject: Neural Network
subject: Control

description: Telesurgical systems that incorporate haptic feedback at the master with a light, compliant slave may provide a superior surgical experience for both patient and health care team. This thesis presents a first investigation of the use of Cerebellar Model Articulation Controllers in just such an application, where the adaptive neural network is used to overcome unknown, nonlinear system dynamics, interaction with unstructured environments, and non-passive operator behaviour in real-time. The controller's output is shown to be Ultimately Uniformly Bounded via the Lyapunov approach, and its stability is verified experimentally. It performs as well as a PID controller during direct real-time bilateral teleoperation and is more robust to rate changes during hard contacts. An auxiliary error that provides torque tracking during interaction and velocity tracking during motion through free space without the need for switching or gain scheduling is evaluated, and key considerations for the implementation of custom controllers with Quanser's 2 DOF Serial Flexible-Joint Robot are discussed.
Additional file 1 of SSS-test: a novel test for detecting positive selection on RNA secondary structure
Creators: name: Beatriz Walter Costa, Maria
name: Höner zu Siederdissen, Christian
name: Dunjić, Marko
name: Stadler, Peter F.
name: Nowick, Katja
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: The Supplemental Material contains additional information on Methods and Data as well as additional Results. (PDF 1517 kb)
Utilidad clínica de los niveles plasmáticos de antipsicóticos en pacientes con trastorno delirante en el ámbito hospitalario
Creators: name: González-Rodríguez, Alexandre
name: Guardia, Armand
name: Álvarez, Aida
name: Betriu, Maria
name: Cobo, Jesús
name: Sanz, Nadia
name: Acebillo, Sidharta
name: Monreal, José Antonio
name: Palao, Diego J
name: Labad, Javier
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
A Combinatorial Algorithm for All-Pairs Shortest Paths in Directed Vertex-Weighted Graphs with Applications to Disc Graphs
Creators: name: Lingas, Andrzej
name: Sledneu, Dzmitry
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: We consider the problem of computing all-pairs shortest paths in a directed graph with real weights assigned to vertices. For an $n\times n$ 0-1 matrix $C,$ let $K_{C}$ be the complete weighted graph on the rows of $C$ where the weight of an edge between two rows is equal to their Hamming distance. Let $MWT(C)$ be the weight of a minimum weight spanning tree of $K_{C}.$ We show that the all-pairs shortest path problem for a directed graph $G$ on $n$ vertices with nonnegative real weights and adjacency matrix $A_G$ can be solved by a combinatorial randomized algorithm in time $$\widetilde{O}(n^{2}\sqrt {n + \min\{MWT(A_G), MWT(A_G^t)\}})$$ As a corollary, we conclude that the transitive closure of a directed graph $G$ can be computed by a combinatorial randomized algorithm in the aforementioned time. $\widetilde{O}(n^{2}\sqrt {n + \min\{MWT(A_G), MWT(A_G^t)\}})$ We also conclude that the all-pairs shortest path problem for uniform disk graphs, with nonnegative real vertex weights, induced by point sets of bounded density within a unit square can be solved in time $\widetilde{O}(n^{2.75})$.
Revisión sistemática: Entre la cultura y el estigma en la esquizofrenia, resultados preliminares
Creators: name: Mosquera Oleas, David
name: Cobo, Jesús
name: Obiols, Jordi E
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Pulsar Timing Arrays: No longer a Blunt Instrument for Gravitational Wave Detection
Creators: name: Lommen, Andrea N.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Pulsar timing now has a rich history in placing limits on the stochastic background of gravitational waves, and we plan soon to reach the sensitivity where we can detect, not just place limits on, the stochastic background. However, the capability of pulsar timing goes beyond the detection of a background. Herein I review efforts that include single source detection, localization, waveform recovery, a clever use of a "time-machine" effect, alternate theories of gravity, and finally studies of the noise in our "detector" that will allow us to tune and optimize the experiment. Pulsar timing arrays are no longer "blunt" instruments for gravitational-wave detection limited to only detecting an amplitude of the background. Rather they are shrewd and tunable detectors, capable of a rich and dynamic variety of astrophysical measurements.
description: 8 pages, 1 figure. Submitted to the proceedings of the 9th Edoardo Amaldi Conference on Gravitational Waves, and the 2011 Numerical Relativity - Data Analysis (NRDA) meeting, held 10-15 July 2011 in Cardiff, Wales, UK, July 10-15 2011. Fixed an omission in the references
Personalidad, comorbilidades y estrategias de afrontamiento en mujeres con Trastornos del Interés y la Excitación Sexual
Creators: name: Tolosa, Iris
name: Domínguez-Cagnon, Helena
name: Díaz Azorín, Ana
name: Lasheras Pérez, Gracia
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?
Creators: name: Avery, Michael B
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Animal Physiology
subject: Biology--Cell
subject: Neuroscience
subject: Biophysics--Medical
subject: Mesenchymal Stem Cell
subject: Mesenchymal Stromal Cell
subject: Aneurysm
subject: Cell Therapy
subject: Pathogenesis

description: Intracranial saccular aneurysms are pathological dilations of cerebral blood vessels that can spontaneously rupture leading to significant morbidity and mortality. Our current understanding of saccular aneurysm pathogenesis involves a complex interplay of predisposing factors and inflammatory cascades, leading to an outpouching at the site of a vessel bifurcation. While several treatments exist today, none are aimed at preventing aneurysm formation. Mesenchymal stem cells are pluripotent cells that have interesting immunomodulatory properties and have been studied in the context of many inflammatory diseases. Few studies have addressed aneurysms and suggest that these cells have the potential to be adjuvants to current treatment modalities in treating fully formed aneurysms. This thesis details the first studies investigating the use of mesenchymal stem cells in preventing the formation of saccular aneurysms. A pre- clinical trial was conducted, as well as an in vivo localization experiment to determine the potential mechanism of action.
Spatially-Resolved Spectroscopy of SDSS J0952+2552: a Confirmed Dual AGN
Creators: name: McGurk, R. C.
name: Max, C. E.
name: Rosario, D. J.
name: Shields, G. A.
name: Smith, K. L.
name: Wright, S. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Most massive galaxies contain supermassive black holes (SMBHs) in their cores. When galaxies merge, gas is driven to nuclear regions and can accrete onto the central black hole. Thus one expects to see dual AGN in a fraction of galaxy mergers. Candidates for galaxies containing dual AGN have been identified by the presence of double-peaked narrow [O III] emission lines and by high spatial resolution images of close galaxy pairs. Spatially-resolved spectroscopy is needed to confirm these galaxy pairs as systems with spatially-separated double SMBHs. With the Keck 2 Laser Guide Star Adaptive Optics system and the OSIRIS near-infrared integral field spectrograph, we obtained spatially-resolved spectra for SDSS J09527.62+255257.2, a radio-quiet quasar shown by previous imaging to consist of a galaxy and its close (1.0") companion. We find that the main galaxy is a Type 1 AGN with both broad and narrow AGN emission lines in its spectrum, while the companion galaxy is a Type 2 AGN with narrow emission lines only. The two AGN are separated by 4.8 kpc, and their redshifts correspond to those of the double peaks of the [O III] emission line seen in the SDSS spectrum. Line diagnostics indicate that both components of the double [O III] emission lines are due to AGN photoionization. These results confirm that J0952+2552 contains two spatially-separated AGN. As one of the few confirmed dual AGN at an intermediate separation of < 10 kpc, this system offers a unique opportunity to study galaxy mergers and their effect on black hole growth.
description: 6 pages, 4 figures, 1 table, submitted to ApJL. See http://people.ucsc.edu/~rmcgurk/McGurk_dualagn.pdf for a high-resolution version of the paper
Effects of Sleeve Gastrectomy and Ileal Transposition, Alone and in Combination, on Food Intake, Body Weight, Gut Hormones and Glucose Metabolism in Rats
Creators: name: Nausheen, Saima
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Body Weight
subject: Glucose Metabolism
subject: Food Intake

description: Gastric bypass surgeries for obesity are hypothesized to produce weight loss and improve diabetes by multiple mechanisms including gastric restriction and lower gut stimulation. The surgeries typically involve rearrangement of the fore-gut, hind-gut or both. We compared the effects of foregut (Sleeve Gastrectomy, SG), hindgut (Ileal Transposition; IT), both (SG+IT), or sham manipulations, on food intake, body weight and glucose tolerance in male SD rats. SG, IT and SGIT surgeries produced transient reduction in food intake and weight gain but improvements in glucose tolerance. SG, IT and SGIT surgeries increased plasma GLP-1 concentrations; IT and SGIT increased PYY concentrations. The protein abundance of key markers of glucose metabolism (e.g. GLUT4, AMPK, PKA, IRS-1) in muscle and adipose tissue were increased following SG, IT, or SGIT. Improvement in glycemic control following these surgeries appears to be independent of changes in weight and is likely due to enhanced lower gut stimulation.
Aspectos etno-psicofarmacológicos de la respuesta al tratamiento en el trastorno delirante
Creators: name: Guardia Delgado, Armand
name: González-Rodríguez, Alexandre
name: Seeman, Mary V
name: Betriu, Maria
name: Monreal, José Antonio
name: Labad, Javier
name: Palao, Diego J
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
Studies of Circumferential Stress Corrosion Cracking of Pipelines
Creators: name: Yang, Yao
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Materials Science
subject: Engineering--Mechanical
subject: circumferential stress corrosion cracking
subject: pipelines
subject: stress enhanced corrosion
subject: crack propagation rate

description: The circumferential stress corrosion cracking (C-SCC) of X46 and X65 steels in a near-neutral pH environment was studied in this work. The steels were found to be susceptible to SCC. The corrosion and cracking behavior of the steels were investigated. The anodic dissolution at the crack tip was enhanced by stress, contributing to the crack propagation. The increase of corrosion rate was associated with the porous corrosion product. The mechanism of SCC was found to be stress dependent. The SCC process was anodic dissolution dominant under a low stress, while the process was mechanical fracture dominant under a sufficiently high stress. The different SCC behaviors between the steels were studied. Compared with X65 steel, X46 steel contained pearlite and has larger grain size, resulting in better adhesion of corrosion product on the steel and lower mechanical strength. Therefore, X46 steel is more susceptible to mechanical fracture, instead of corrosion.
Implicaciones del confinamiento durante la pandemia COVID-19 en las recaídas de pacientes en seguimiento en un Programa de Primeros Episodios Psicóticos
Creators: name: Tost, Meritxell
name: Llauradó, Laura
name: Pérez-Muñoz, Sara
name: Montalvo, Itziar
name: Barbero, Juan David
name: Gago, Estefanía
name: Olasz, Irina
name: Miñano, María José
name: Mesa, Nora
name: Palao, Diego J
name: Pàmias, Montserrat
name: Monreal, José Antonio
name: Labad, Javier
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
An Exploration of Persistence and Desistance in Offending: Accumulating Disadvantage?
Creators: name: Humphrey, Tamara
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Criminology and Penology
subject: Criminology
subject: FOS: Law
subject: Life-course Criminology
subject: Career Criminals
subject: Desistance
subject: Quantitative and Qualitative Methods

description: Research has consistently noted that a small group of offenders is responsible for a large proportion of all offenses and the bulk of serious and violent crimes. The investigation into factors that influence offending over the life course is noted to be especially important for this group of offenders, often labelled as life-course persistent or high-risk offenders, because of the risk they present to public safety. Yet, much of the research that considers factors related to offending patterns over the life course employs samples comprised of adolescents and young adults. To address this limitation, the current study examines elements of offending trajectories among a population of offenders from a large municipality in Alberta who have committed numerous violent offenses and have criminal careers of up to 55 years in length (N=411). These offenders ranged in age between 26 and 89 years. Quantitative and qualitative analytic strategies are used to first investigate the direct and indirect effects of the accumulation of multiple adversities in childhood on two key dimensions of a criminal career: career length and frequency of offending. A second component of the analysis considers an under-developed part of the process of desistance, intermittency in offending, or “crime-free gaps”. Given the role that bonds to institutions of informal social control are noted to play in exiting from a life of crime, I examine the effect of social bonds in adulthood on the time between offenses. Results indicate that adverse childhood experiences (ACEs) are directly related to criminal career length and indirectly related to frequency of offending through attachment to employment in adulthood; further, that social bonds to the institutions of work and marriage lengthen the gaps between offenses, thereby reducing the risk of reoffending over time. The qualitative analyses highlighted the importance of considering the variation over time in the presence and absence of bonds for both persistence and intermittency in offending. The theoretical and policy implications of the results are discussed, along with directions for future research in this area.
Impacto psicológico del confinamiento en una muestra comunitaria de mujeres adolescentes y jóvenes españolas
Creators: name: Vall-Roqué, Helena
name: Andrés, Ana
name: Saldaña, Carmina
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2021

description: Psicosomàtica y Psiquiatría, Núm. 15 (2020)
The Impact of Ethical Regulation and Developer Reputation Scoring on Information Security Professionalism Practice
Creators: name: Chukuka, Benedict
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Computer Science
subject: Information Technology
subject: Ethics
subject: Codes of Conduct
subject: Ethical Agreements
subject: Policies
subject: Developer Licensing

description: We consider the forces of ethical regulation and developer licensing in a software liability attribution regime as two factors that may influence the information security discipline. We conduct investigations that serve to provide insight into how these forces may play out in a regulatory environment of the future. Our first investigation entails a broad survey of ethical policies governing information security courses, and thus, the student trainee experience. We demonstrate the feasibility of fusing current divergent ethical policies into a standard policy on information security. Accordingly, we derive an ethical policy prototype that is based on the common elements of 329 different ethical policies. In our second investigation, we demonstrate a model for determining security reputation scores for individual software developers based on historical introduction of security bugs into source code. We employ information on 1,119 security bugs to compute developer reputation scores across 9 open source software development projects.
Transversity studies with protons and light nuclei
Creators: name: Scopetta, Sergio
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A general formalism to evaluate time-reversal odd transverse momentum dependent parton distributions (T-odd TMDS) is reviewed and applied to the calculation of the leading-twist quantities, i.e., the Sivers and the Boer-Mulders functions. Two different models of the proton structure, namely a non relativistic constituent quark model and the MIT bag model, have been used. The results obtained in both frameworks fulfill the Burkardt sum rule to a large extent. The calculation of nuclear effects in the extraction of neutron single spin asymmetries in semi-inclusive deep inelastic scattering off transversely polarized $^3$He is also illustrated. It is found that the nuclear effects described by an Impulse Approximation approach are under theoretical control.
description: 11 pages, 6 figures, invited talk at the "XIII Conference on Problems in Theoretical Nuclear Physics in Italy", Cortona, Italy, 6-8 April 2011. To be published in Journal of Physics: Conference Series
Design and R&D of very forward calorimeters for detectors at future e+e- collider
Creators: name: Bozovic-Jelisavcic, Ivanka
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Detectors at future e+e- collider need special calorimeters in the very forward region for a fast estimate and precise measurement of the luminosity, to improve the hermeticity and mask the central tracking detectors from backscattered particles. Design optimized for the ILC collider using Monte Carlo simulations is presented. Sensor prototypes have been produced and dedicated FE ASICs have been developed and tested. For the first time, sensors have been connected to the front-end and ADC ASICs and tested in an electron beam. Results on the performance are discussed.
description: Contribution to the 2011 Europhysics Conference on High Energy Physics-HEP2011, Grenoble, Rh\^one-Alpes, July 21-27 201
Additional file 1 of Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy
Creators: name: Li, Guang
name: Ling, Mingjian
name: Yu, Kunyi
name: Yang, Wei
name: Liu, Qiwen
name: He, Lijuan
name: Cai, Xuzi
name: Zhong, Min
name: Mai, Ziyi
name: Sun, Rui
name: Xiao, Yuanling
name: Yu, Zhiqiang
name: Wang, Xuefeng
Publisher: name: figshare
Year: 2022
Subjects: Molecular Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Additional file 1. Additional information.