title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÐµÐ½Ð¾ÑÐ¸Ð±ÑÐ°ÑÐ° Ð½Ð° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² Ð¿ÑÐ¾- Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ð¾Ð² Ð² Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÐºÐ¾ÑÐµ ÐºÑÑÑ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The effect of fenofibrate on the expression of pro- and anti-inflammatory cytokine genes in the temporal cortex of rats in the lithium-pilocarpine model of epilepsy
Creators: name: Ð¨Ð°Ð±ÑÐ½Ð¸Ð½Ð°, Ð¡Ð¾ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: PPARÎ±
ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð²Ð¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ
ÑÐµÐ½Ð¾ÑÐ¸Ð±ÑÐ°Ñ
GFAP
Aif1
Il1b
Il1ra
Ilrn
ÐÐ¢-ÐÐ¦Ð
epilepsy
temporal epylepsy
lithium-pylocarpine model
fenofibrate
RT-PCR

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð°Ð³Ð¾Ð½Ð¸ÑÑÐ° PPARÎ± ÑÐµÐ½Ð¾ÑÐ¸Ð±ÑÐ°ÑÐ° Ð½Ð° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² Ð¸Ð½ÑÐµÑÐµÑÐ° â Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ð¸ Ð°ÑÑÑÐ¾- Ð¸ Ð¼Ð¸ÐºÑÐ¾Ð³Ð»Ð¸Ð°Ð»ÑÐ½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÑÐ¾- Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ð¾Ð² â Ð² Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÐºÐ¾ÑÐµ ÐºÑÑÑ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ ÐÐ°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ ÐÐ­Ð¤Ð Ð ÐÐ. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÐºÐ»ÑÑÐ°Ð»Ð° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½Ñ: Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð°ÑÑ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² Ð¸Ð½ÑÐµÑÐµÑÐ° Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸Â  ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð¼Ð ÐÐ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸ ÐÐ¢-ÐÐ¦Ð  Ð¸ ÐÐ¦Ð  Ð² ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐµÐ¼ÐµÐ½Ð¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð²ÑÑÐ²Ð¸Ð»Ð¾ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾Ðµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð° GFAP Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð¼Ð ÐÐ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ ÑÐºÑÐ¿ÑÐµÑÐ¸Ð¸ Aif1, Il1b, Il1ra, Ilrn Ð½Ðµ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð½Ð¾Ð²ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸.
description: The work is devoted to studying the effect of the PPARÎ± agonist fenofibrate on the expression of genes of interest â markers of activation of astro- and microglial cells, as well as pro- and anti-inflammatory cytokines â in the temporal cortex of rats in the lithium-pilocarpine model of epilepsy. The work was carried out at the Laboratory of Molecular Mechanisms of Neural Interactions at the Institute of Experimental Physics and Biology of the Russian Academy of Sciences. The work included an experiment: the dynamics of expression of genes of interest in the lithium-pilocarpine model of epilepsy was studied at the mRNA level using RT-PCR and real-time PCR. The study revealed a significant change in the expression of the GFAP gene at the mRNA level in the lithium-pilocarpine model of temporal lobe epilepsy, but no significant changes in the expression of Aif1, Il1b, Il1ra, Ilrn were found. The data obtained can be used in the development of new methods of antiepileptic therapy.