cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Barriers to effectiveness: artemisinin combination therapies (ACTs) and the health system
Creators: name: Rao, Bhargavi
Publisher: name: Imperial College London
Year: 2015

description: As international funding for malaria programmes plateaus, it is critical to better understand how to implement interventions such as first-line Artemisinin Combination Therapies (ACTs) most effectively through an existing health system. This thesis presents an expansion of a mathematical model of malaria transmission to provide insight to the role of health systems factors as barriers to the effectiveness of ACTs, and interventions to overcome them; considering dimensions of access to care, different sectors through which care is delivered, and the quality of care provided. Data from the IMPACT 2 study in Tanzania was used to parameterise this approach. Primary-care based interventions had most impact on transmission. In low-prevalence scenarios some single interventions, e.g. ensuring 100% care-seeking, eliminated parasite prevalence. Diagnostic-led therapy with adequate stocks of ACTs was as effective in all settings as a policy of presumptive treatment, reducing parasite prevalence in under-fives in moderate transmission settings by up to 86% depending on the sector of implementation. Modelling combinations of hospital-based interventions shifted the pattern of severe malaria away from a peak at early ages (greater than 70% relative reduction in 0-5 year olds in medium transmission settings) towards a more sustained lower incidence across 0-20 years of age as seen in low prevalence settings. This was not immune-mediated and demonstrates the role of health systems interventions preventing the development of severe malaria in those at risk, and reducing mortality. Weak health systems and a poorly controlled diversity of antimalarial sources act as barriers to deploying ACTs effectively both as a control measure and first-line treatment. Addressing these constraints needs consideration of existing healthcare provision and local priorities, e.g. reducing ACT wastage, but through specific planning may improve progress towards targets set by Roll Back Malaria to decrease clinical disease and mortality, and in low transmission settings, to approach elimination.
Deciphering mechanisms of gene regulation through novel strategies for mapping genome architecture
Creators: name: Beagrie, Robert Alexander
Publisher: name: Imperial College London
Year: 2015

description: The regulation of gene expression plays a crucial role in development and disease. Regulation at the level of transcription is intimately linked with the positions of genes within the nucleus, both in terms of their association with structural components such as the nuclear lamina and in terms of their proximity to genomic elements such as enhancers or other genes. Methods based on Chromosome Conformation Capture (3C) have begun to disentangle the complicated relationship between chromatin folding and gene expression. However, 3C-based techniques have important limitations that restrict their ability to address important biological questions. Crucially, they struggle to detect interactions involving three or more genomic features because they rely on ligation of DNA fragment ends. To address these limitations, I implemented and optimized Genome Architecture Mapping (GAM), a ligation-free approach for determining genome topology. GAM infers the spatial proximity between genomic elements by measuring their co-segregation in thin nuclear slices, and places no upper limit on the number of regions that can be detected in a simultaneous interaction. I apply GAM to mouse embryonic stem cells and develop a computational pipeline to analyse the resulting dataset. GAM independently verifies key features of chromosome folding identified by 3C-based methods, including topologically associating domains (TADs). Using a statistical model, we find many non-random interactions spanning tens of megabases, which preferentially involve interactions between active genes and enhancers, between pairs of active genes and between pairs of enhancers at 30 kb resolution. We also explore simultaneous, three-way contacts between TADs and identify super-enhancers and highly-transcribed TADs as the most likely to interact at higher multiplicity. Strikingly, we uncover an antagonistic relationship between lamina association and TAD triplet formation. Finally, we show that GAM can be used to measure chromatin compaction and radial positioning.
Determinants of adult influenza and tetanus vaccination in the UK
Creators: name: Wheelock, Ana
Publisher: name: Imperial College London
Year: 2015

description: Vaccination coverage in adults remains suboptimal. Health organisations have only recently begun to recognise the role of socio-psychological factors in vaccination decisions. These factors are particularly important, given that they are inherently amenable to policy and behaviour change. This thesis employs a mixed-methods approach to investigate the determinants of adult seasonal influenza and tetanus vaccination in the UK general adult population. It focuses on socio-psychological factors and draws upon health behaviour models, heuristics and biases and customer journey mapping theoretical approaches to guide research and elucidate findings. A narrative and a systematic review and meta-analysis reveal there are a number of socio-psychological factors frequently associated with vaccination, particularly influenza and influenza vaccine risk perception, perceived vaccine effectiveness and reported physician recommendation, and show that most of the evidence in this area is produced in the US. They also highlight the importance of some vaccine risk perceptions, such as influenza-like symptoms and unspecific side-effects, and demonstrate that the existing evidence is highly heterogeneous and often lacking in quality, further supporting a case for robust empirical research on this topic. Two qualitative studies show that vaccine uptake is largely driven by people’s risk perception of influenza and tetanus, and that the tetanus vaccine is perceived as safe, unlike the influenza vaccine. They also reveal how specific healthcare ‘touchpoints’ across the immunisation journey can facilitate or hinder uptake. A novel finding is that certain childhood experiences can influence adult vaccination decisions. Two cross-sectional survey studies show that a compact set of variables can predict 91% of influenza and 75% of tetanus vaccination behaviour. They also demonstrate that socio-psychological factors are the most important determinants of vaccination behaviour. This thesis shows that incorporating socio-psychological dimensions in all aspect of immunisation policy, from surveillance systems to policy evaluation, is critical to improve vaccination rates.
Organic Farming as a Rural Development Factor in Poland – the Role of Good Governance and Local Policies
Creators: name: Śpiewak, Ruta
name: Jasiński, Jakub
Publisher: name: International Journal on Food System Dynamics
Year: 2020
Subjects: organic farming; rural development; good governance; local governance, growth factors; endogenous resources

description: The main goal of this article is to assess the conditions under which market-oriented and formally organised organic farming might become a factor for local development. The main question is: to what degree is the impact of this factor (organic farming) due to local policies and the quality of local governance? Based on research carried out in 2013 and in 2016 in various parts of Poland, the authors demonstrate when and under what conditions and circumstances organic farming may improve farmers’ social and economic conditions as well as the overall development of areas with a significant organic agricultural sector (proportionally to the local scale). The preliminary findings underline that local authorities in rural areas are an institution that can significantly contribute to the maintenance and development of organic farming in Poland.
description: International Journal on Food System Dynamics, Vol 11, No 1 (2020)
CCWI2017: F142 'Cumulative Pressure Induced Stress for Characterising Pressure Transients and Variability in Water Supply Networks'
Creators: name: Stoianov, Ivan
name: Hoskins, Asher
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: In this paper, we introduce and apply novel metrics to quantitatively characterise and account for the broad spectrum of pressure cycles, variations and transient events that continuously occur in operational systems. The Cumulative Pressure Induced Stress (CPIS TM ), which builds upon advances in fracture mechanics and fatigue induced failures, includes all pressure cycles irrespective of their amplitude and frequency within a moving 24-hour time window. Pressure is continuously sampled at 128S/s. Embedded signal processing algorithms combined with cycle counting methods allow for CPIS TM to reduce a spectrum of varying pressure variations into a set of stress reversals. In this way, quantitative metrics for characterising the cumulative pressure induced stress and individual transient events are continuously available to network operators within a risk-based “pipe stress” warning system. The described metrics and methods and their implementation enable utilities to prioritise interventions and repairs (early asset stress warning) in order to maintain steady-state (“calm”) hydraulic conditions, and assess the long-term impact of the dynamic hydraulic behaviour on assets failures (pipes, pumps, control valves, air valves, surge vessels etc).
Multilevel process monitoring: A case study to predict student success or failure
Creators: name: Huberts, Leo C. E.
name: Schoonhoven, Marit
name: Does, Ronald J. M. M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: In this case study, we demonstrate the use of multilevel process monitoring in quality control. Using high school data, we answer three research questions related to high school student progress during an academic year. The questions are (1) What determines student performance? (2) How can statistical process monitoring be used in monitoring student progress? (3) What method can be used for predictive monitoring of student results? To answer these questions, we worked together with a Dutch high school and combined hierarchical Bayesian modeling with statistical and predictive monitoring procedures. The results give a clear blueprint for student progress monitoring.
Français pour les bilingues 5e/6e: Défi lecture
Creators: name: Trommer, Bernadette
name: Cuenat, Mirjam
name: Oliveira, Marta
Publisher: name: Pädagogische Hochschule FHNW
Year: 2020
Subjects: subject: français
subject: bilingue
subject: école primaire
subject: 440 - Französisch, romanische Sprachen allgemein
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Die Lernparcours sind spezifische Materialien, um französischsprachige Kinder, die in der Deutschschweiz den Fremdsprachenunterricht Französisch auf der Primarstufe besuchen, angemessen zu fördern.
Dopaminergic mechanisms underlying psychosis
Creators: name: Bloomfield, Michael
Publisher: name: Imperial College London
Year: 2014

description: Schizophrenia is a potentially devastating mental illness with a complex aetiology, in which the odds ratios for environmental risk factors for the disorder are greater than the odds ratios of any single gene hitherto identified. Within schizophrenia, striatal dopamine dysfunction has been proposed to underlie the development of psychosis. The Aberrant Salience hypothesis provides an explanatory model based on empirical findings to explain how psychotic symptoms may arise from striatal hyperdopaminergia, whereby multiple risk factors converge to elevate striatal dopamine synthesis capacity as the Final Common Pathway to psychosis. Two important epidemiological risk factors for the disorder are chronic cannabis use and longterm psychosocial stress, both of which have evidence supporting effects on the dopamine system. Environmental risk factors are by their very nature modifiable, and so this thesis examined whether these environmental risk factors were associated with the same dopaminergic abnormalities that have been observed in schizophrenia with 3,4-dihydroxy-6- [18F]-fluoro-l-phenylalanine Positron Emission Tomography. This thesis also examined whether cannabis users exhibit aberrant salience processing using a behavioural task, the Salience Attribution Task. This thesis found that long-term cannabis use was associated with reduced dopamine synthesis capacity and no relationship was found between striatal dopamine synthesis capacity and cannabis-induced psychotic-like symptoms. Whilst cannabis use was not associated with increased aberrant salience processing, there was a relationship between cannabis-induced psychotic-like symptoms and aberrant salience processing. This thesis found that long-term psychosocial stress is associated with reduced dopamine synthesis capacity, although this finding may be due confounding factors. However, a positive relationship was observed between childhood and recent adult stressors and dopamine synthesis capacity. These findings call into question the hypothesis that cannabis increases the risk of psychosis by inducing the same changes observed in schizophrenia, although there some evidence to support the hypothesis that psychosocial stressors do increase risk via this mechanism.
CCWI2017: F110 'A model pre-processing approach for improving calibration-based leakage detection using a genetic algorithm'
Creators: name: S. Sophocleous
name: D. Savic
name: Z. Kapelan
name: Y. Shen
name: P. Sage
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The paper presents a systematic approach for narrowing down the search for leaks and unknown closed valves in the water distribution network. The developed approach is applied on a real system and a calibration problem is solved for the ultimate purpose of detecting existing background leakage hotspots. A Genetic Algorithm is used to solve the optimization problem searching for calibration parameter values, while minimizing the differences between observations and model outputs. The optimisation problem is coded in two ways, a scenario-based framework where the maximum number of leaks and closed valves in the network is specified and non scenario-based framework. The leak detection methodology takes advantage of the new pre-processing method to reduce the search space size for the optimisation problems to only significant parameters that contribute to the fitness and hydraulic changes of the model. Artificial calibration data are generated by means of hydraulic modelling employed to mimic planned hydrant discharges during a low demand period. The staged approach demonstrates that the search for location and range of flows for unknown leaks can be reduced to only a small part of the network components. This appears to provide additional benefits towards calibrations problem complexity reduction and reduced time in finding leaks.
CCWi2017: F90 'Pipe Leak Diagnostic using Empirical Mode Decomposition (EMD) and Automatic Selection of the Intrinsic Mode Function (IMF)'
Creators: name: Hanafi.M.Yusop
name: M.F.Ghazali
name: M.F.M.Yusof
name: M.A.PiRemli
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: In a recent study, the analysis of pressure transient signals could be seen as an accurate and low- cost method for leak and feature detection in water distribution systems. Transient phenomena occur due to sudden changes in the fluid’s propagation in pipelines system caused by rapid pressure and flow fluctuation due to events such as closing and opening valves rapidly or through pump failure. In this paper, it is to apply the Hilbert-Huang transform (HHT) as a method to analyse the pressure transient signal. The HHT is a way to decompose a signal into intrinsic mode functions (IMF). However, this method has the difficulty in selecting the suitable IMF for the next data post-processing method which is Hilbert Transform (HT). The current paper presents the implementation of an integrated kurtosis-based algorithm for a z-filter technique (I-kaz) to kurtosis ratio (I-kaz-Kurtosis), for this allows automatic selection of the IMF that should be used. This technique is demonstrated on a 57.90-meter medium high-density polyethylene (MDPE) pipe installed with a single artificial leak. The analysis results using the I-kaz-kurtosis ratio revealed that the method can be used as an automatic selection of the IMF although the noise level ratio of the signal is lower. Despite this, the I-kaz-kurtosis ratio method is recommended as a means to implement an automatic selection technique of the IMF for HHT analysis.
CCWI2017: F107 'A Perspective on Reducing Uncertainties in Water Distribution Network Operation Using Clusters'
Creators: name: Lifshitz Ron
name: Ostfeld Avi
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: In water distribution system operation problems, a solution is often, if not always, valid for a small variety of forecasted scenarios. The number of unknown variables, such as consumer consumptions, pipe smoothness, leaks or infections makes the forecasting of the conditions in which the network operates almost impossible. On the other end, most of the solution procedures take use of deterministic models such as water and energy balance or demand patterns – and even stochastic models cannot predict the conditions for which the problem in hand is defined. This procedure of using exact solution models for inexact problems is reconsidered while a methodology of using clusters in water distribution systems is demonstrated on selected regions, utilizing simple examples as an effective tool for bridging the gap.
title: Data Stewardship Maturity Report for GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite produced by NEODAAS (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00234
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Aerosol Detection (Suspended Matter) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00245
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Land Surface Albedo Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00248
Datenmanagementpläne: Step by step
Creators: name: Jordan, Sabrina
Publisher: name: Zenodo
Year: 2024
Subjects: Forschungsdatenmanagement
FDM
Forschungsdaten
Metadaten
Datenmanagement
Datenmanagementplan
DMP
Werkzeug
Replizierbarkeit
Nachnutzung
Rechtemanagement
FAIRe Daten
FAIR-Prinzipien
Repositorium
Versionierung
Versionskontrolle
Datensicherung
Archivierung
Langzeitarchivierung
Namenskonvention
Lizenzierung
Forschungsförderung
Drittmittelförderung
research data management
RDM
research data
metadata
data management
data management plan
tool
replicability
reuse
rights management
FAIR data
FAIR principles
repository
versioning
version control
data preservation
archiving
long-term archiving
naming convention
licencing
research funding
third-party funding
RDMO
Research Data Management Organiser
HeFDI Data Week 2024

description: Ein Datenmanagementplan (DMP) ist eine ein- bis zweiseitige Zusammenfassung, in der Sie erklären, wie Sie die mit den im Laufe Ihres Projekts gesammelten Daten umgehen werden. Die Planung der Datenverwaltung ermöglicht die Öffnung von Forschungsdaten, verringert das Risiko des Datenverlusts und ist ein wesentlicher Bestandteil guter wissenschaftlicher Praxis. Diese Präsentation bietet den Teilnehmern einen Leitfaden für die Erstellung von Datenmanagementplänen. Es werden wichtige Schritte von der Planung bis zur Umsetzung erläutert, um Daten effektiv zu verwalten. Praktische Tipps und Ratschläge helfen den Teilnehmern, ihre Daten effizient zu verwalten und die Anforderungen ihrer Forschungsprojekte zu erfüllen.
description: Die HeFDI Data Week 2024 ist eine ganzwöchige Veranstaltung, welche im Kontext des bundesweiten „Digitaltags“ angeboten wird. Die Online-Veranstaltung richtet sich an Forschende, Lehrende, Studierende und alle, die mehr über Datenmanagement, FAIR Data und Code und die damit verbundenen Herausforderungen erfahren möchten. Im Laufe der Woche werden verschiedene Themen und Herausforderungen im Zusammenhang mit Forschungsdaten behandelt sowie Dienste und Angebote verschiedener hessischer Infrastruktur-Einrichtungen und Zentren vorgestellt. 

Werfen Sie auch einen Blick auf andere Veröffentlichungen der HeFDI Data Week 2024 oder die Veröffentlichungen anderer HeFDI-Events in der HeFDI-Zenodo-Community.

Wenn Sie Vorschläge und Anliegen zu Themen für unsere HeFDI-Events haben, wenden Sie sich gerne an die HeFDI-Geschäftsstelle (hefdi@uni-marburg.de). Falls Sie regelmäßig über unsere Angebote und Veranstaltungen informiert werden möchten, registrieren Sie sich gerne für unseren Newsletter. 
description: Die HeFDI Data Week 2024 ist ein Angebot der Landesinitiative HeFDI - Hessische Forschungsdateninfrastrukturen, welche vom Hessischen Ministerium für Wissenschaft und Forschung, Kunst und Kultur (HMWK) finanziert wird.
Für eine «gesunde» Lehrplaneinführung
Creators: name: Högger, Dominique
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: subject: Gesundheitsfördernde Schule
subject: Lehrplan 21
subject: Unterrichtsentwicklung
subject: Betriebliches Gesundheitsmanagement BGM
subject: Schulentwicklung
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Im Lehrplan 21 finden sich zahlreiche Kompetenzziele, die für die Gesundheit der Schülerinnen und Schüler bedeutungsvoll sind. Darüber hinaus ist die bevorstehende Schul-, Unterrichts- und Personalentwicklung hin zum neuen Lehrplan eine Herausforderung, die die Gesundheit von Lehrpersonen und Schulleitungen ganz unmittelbar betreffen kann. Die Zusammenstellung wirft sechs Schlaglichter auf die Lehrplaneinführung und deren Bedeutung für die Gesundheit.
CCWi2017: F150 'APPLICATION OF LEAST SQUARES SUPPORT VECTOR MACHINES AND ACOUSTIC MEASUREMENTS FOR LEAK FLOW RATE PREDICTION'
Creators: name: Collins, Richard
name: Butterfield, Joseph D.
name: Meruane, Viviana
name: Meyers, Gregory
name: Beck, Stephen
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Leakage from water distribution pipes represent a huge issue worldwide with economic. Leaks are normally found by placing sensors either side of the leak recording the leaks acoustic emission as it discharges the leak hole. As the leak noise is intrinsic to the leak, it contains information which could provide information about the leak, including the leak flow rate. Any tool which can accurately determine the leak’s flow rate could be used by water industry practitioners in order to prioritise leakage repair activities by repairing the higher leak flow rates first. This will result in economic savings through reduced water lost and better allocation of company resources. This paper demonstrates a small element of research undertaken at the University of Sheffield in collaboration with several UK water companies. The aim of the research is to develop a tool in order to predict leak flow rate using acoustic emission sensors. The research uses Least Squares- Support Vector Machines in order to predict leak flow rate in MDPE pipe using high quality data from a unique experimental pipe rig. The results demonstrate that there is sufficient information within the leak’s acoustic emission signal in order to predict leak flow rate. Therefore the research represented in this paper presents a tool which can be used by water industry practioners to prioritise leak repair.
Titin: an analysis of genetic variation and cardiac phenotype
Creators: name: Roberts, Angharad Margaret
Publisher: name: Imperial College London
Year: 2014

description: Non ischaemic dilated cardiomyopathy (DCM) is an important cause of heart failure leading to chronic morbidity and death and as such is a major health burden. DCM is familial in up to 50% of cases but is genetically heterogeneous, hindering both genotype-phenotype studies and the application of genetic information for stratified patient management. TTN truncating variants (TTNtv) cause severe and familial DCM, but sometimes occur in healthy individuals, posing challenges for the interpretation of these variants. In this PhD thesis, the power of quantitative cardiac MRI (CMR) is integrated with targeted resequencing of TTN in order to assess the relationship between TTN genotype, cardiac phenotype and clinical outcomes. A prospectively recruited DCM cohort was established following CMR assessment in 374 patients (88% Caucasian, 72% male, mean age 54 ± 35 years, mean left ventricular ejection fraction (LVEF) 38% ± 24.5%, mean indexed end-diastolic volume 129 ± 141 mm). Following several iterations of design, refinement and testing an NGS assay was produced that captures all TTN coding exons and splice sites. Optimal parameters for sequencing and analysis of variants were established and genotype data compiled from 374 prospective, unselected cases, 155 end-stage retrospective cases, and 308 MRI phenotyped healthy volunteers. These data were integrated with that from 3603 population subjects and together used to identify molecular signatures that aid interpretation of TTN truncations both in DCM and as incidental findings. Overall, TTNtv were identified in 1.4% of controls, 13% of unselected and 22% of end-stage DCM cases (OR = 13, P= 2.8x10-43, DCM vs controls) confirming TTN as the commonest cause of genetic DCM in all patient groups. TTNtv-containing exons in DCM have higher usage than those in controls (P=2.5x10-4) and these are estimated to have >93% probability of pathogenicity (likelihood ratio 14). Compared to TTNtv-ve DCM, TTNtv+ve patients had lower LVEF (P=0.02), thinner LV walls (P=0.02), and a higher incidence of sustained ventricular tachycardia (P=0.001). C-terminus TTNtv were also associated with lower LVEF versus N-terminus (β=-18±7%, p=0.006) and were more common in end-stage disease. Together these data provide the first insight into genotype-phenotype correlations and will be of benefit in variant interpretation and patient stratification in TTN-based DCM.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Daytime Cloud Optical and Microphysical Properties (DCOMP) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00247
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Cloud Type and Phase Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00257
Singing to the lute in the early 16th century
Creators: name: Roux, Emma-Lisa
Publisher: name: Hochschule für Musik Basel FHNW, Schola Cantorum Basiliensis
Year: 2022
Subjects: subject: 780 - Musik

description: This study focuses on the art of self-accompanied song in the first half of the 16th century, by firstly examining settings of public and private performances of secular and sacred music in French and Italian courts as well as surviving accounts of singing instrumentalists from Italy and Spain, and repertoire for voice and lute found in French, Italian or Spanish sources. Secondly, this study explores didactical sources, such as instructions for lute, vihuela, recorder or viol, or music theory and composition. The third part of the study concentrates on the process of creating progressive material to guide the lutenist to sing to their instrument, based on the historical sources and the repertoire studied in the first two parts.
Sickle cell and the burden of disease in England
Creators: name: AlJuburi, Ghida
Publisher: name: Imperial College London
Year: 2014

description: Background Sickle cell disorders (SCD) are the most common inherited blood disorders in England. Without prompt diagnosis and proper treatment, they can be a serious source of morbidity and mortality. Sickle cell diseases affect mainly black minority and ethnic populations, and have so far received relatively low priority from a health policy perspective. Antenatal and newborn screening, the development of minimum standards, antibiotic prophylaxis, comprehensive immunisations, and preventive diagnostic tests have positively influenced SCD management. There remains an unclear picture as to the trends and health care utilization of patients with SCD in England. Aims This study looks at the burden of disease in England by assessing hospital admissions, readmissions and related costs. It also aims to identify gaps in care and prevention which may identify possible contributors to avoidable admissions. Findings Using Hospital Episode Statistics (HES) data, trends for SCD hospital admissions in England showed a rise in 50% of hospital admissions over a 10 year period. The most deprived areas had a higher rate of readmission and in-patient mortality among those with SCD. Adolescents had a higher rate of readmission possibly identifying a gap in health care access. Local findings in a high prevalence area showed that the majority of admissions were for a short length of stay and 74% of patients accounted for multiple admissions. A patient focus group and questionnaire both identified potential gaps in care and prevention. Conclusion Through the use of 6 studies which showed the SCD admission rates in England, the readmission rates, local admissions, costs associated with admission and patient perspectives in both care and prevention, there is a clearer picture as to the trends and health care utilization of patients with SCD in England. The studies suggest that ascertaining the prevalence of at-risk groups in England as well as addressing inequalities in health care access among minority groups and areas of high disease prevalence can further aid in disease management. Shifting diagnostic and follow-up care from acute care facilities to primary care facilities and promoting preventive care measures and adherence to standards and guidelines may possibly decrease the cost burden, reduce avoidable hospital admissions and increase the timeliness and effectiveness of disease management. Investing in training and education of primary care physicians for sickle cell diseases may also improve quality of care.
Weibull, κ-Weibull and 3-parameter extended Weibull distributions
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2022
Subjects: κ-Weibull distribution
Weibull distribution
3-parameter extended Weibull distribution
Marshall–Olkin extended distributions
Log-logistic distribution
Hazard function
Modeling failure times
Burr distribution
Exopnentiated Weibull distribution
q-Weibull distribution

description: Here we will consider a function of κ-statistics, the κ-Weibull distribution, and compare it to the well-known Weibull distribution. The κ-Weibull will be also compared to the 3-parameter extended Weibull function, obtained according to the Marshall–Olkin extended distributions. The log-logistic distribution will be considered for comparison too, such as the exponentiated Weibull, the Burr and the q-Weibull distributions. The most important observation, coming from the proposed calculations, is that the κ-Weibull hazard function is strongly depending on the values of parameter κ, a parameter which is deeply influencing the behaviour of the tail of the probability distribution. As a consequence, the κ-Weibull function turns out to be quite relevant for generalizations of the Weibull approach to modeling failure times.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Cloud Height (Top and Base) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00256
Integrative genetic and network approaches to identify key regulators of cardiac fibrosis
Creators: name: Moreno Moral, Aida
Publisher: name: Imperial College London
Year: 2015

description: Excessive fibrogenic response is a pathological hallmark of chronic complex diseases, including cardiovascular disease. To date, very few gene targets for cardiac fibrosis that led to effective treatments have been identified in humans. In this thesis I study and dissect the genetic component underlying cardiac fibrosis. This study integrates histomorphometric measurements of fibrosis in the rat left ventricle (LV) with gene expression (RNA-Seq from LV) and genetic data in a panel of recombinant inbred (RI) rat strains (n=30). In addition, I integrated RNA-seq LV and genetic data in humans (n=187, healthy and dilated cardiomyopathy (DCM) patients), as well as DCM genome-wide association studies (GWAS) data. I started by carrying out an unbiased co-expression network analysis in the rat heart. The reconstructed cardiac transcriptional modules were associated with quantitative levels of fibrosis. Co-expression networks were also independently built in the heart of DCM patients and by using the rat data, co-expression networks associated with fibrosis, conserved across rats and humans and not present in control human heart were prioritised. In the prioritised networks, I also analysed their cardiac cell type specificity, differential expression after TGFβ induction, potential driving transcription factors and conservation in other fibrotic diseases by analysing human data collected from other organs. Furthermore, I aimed to identify common genetic regulators of the networks (also called master genetic regulators) by using Bayesian multivariate regression approaches. Finally, I integrated GWAS data in DCM (n=2,287) to dissect the genetic basis of DCM. This systems genetics study evidences that there are transcriptional processes involved in the human cardiac fibrogenic response that are conserved across rats and humans, some of them also underlying DCM aetiology. In an attempt to suggest new gene targets for cardiac fibrosis, I also identified the WWP2 gene as a novel trans-acting genetic regulator of cardiac fibrosis.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Aerosol Optical Depth and Aerosol Particle Size Distribution Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00249
title: Data Stewardship Maturity Report for NOAA JPSS Ozone Mapping and Profiler Suite (OMPS) Version 8 Nadir Profile Ozone (V8Pro) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00252
The application of innovative virtual world technologies to enhance healthcare education
Creators: name: Patel, Vishal Arun
Publisher: name: Imperial College London
Year: 2014

description: The World Wide Web has evolved leading to the development of three- dimensional virtual worlds. These are online, accessible environments through which a user may engage, communicate and interact via their digital self, known as their avatar. These virtual worlds offer the opportunity for further content to be generated in order to provide new environments and simulations. This research work explores the potential of virtual worlds in providing an educational platform for healthcare professionals. In order to establish this, the effectiveness of a virtual world environment was determined through the use of a custom-built virtual world operating theatre, which was utilised to train operating theatre novices in preparation for the real-life environment. Following the application of a virtual world environment, this research explored the development of a virtual patient scenario for training healthcare professionals. The virtual patient scenario focused on the management of adverse events associated with medical infusion devices with a nurse user group assessing the simulation face validity. The next step was to devise a methodology to develop a series of immersive virtual patients. This involved the use of allied web technologies to produce a robust, reproducible method of 3D virtual patient generation. Three virtual patients were constructed, with distinct surgical pathologies at three levels of increasing complexity. Subsequently the face, content and construct validity of the virtual patients was established to differentiate surgeons of different training grades. Finally the virtual patients were utilised to emulate real clinical situations, in which handoff of patient information occurred. The virtual patients were used to establish if the quality of handoff impacted on the subsequent patient management in a simulated setting. Overall this research has demonstrated the efficacy of virtual world environments and simulations in providing an alternative educational platform for healthcare professionals.
CCWi2017: F64 'ANALYSIS OF SHOWER WATER USE AND TEMPERATURE AT A SOUTH AFRICAN UNIVERSITY CAMPUS'
Creators: name: BE Botha
name: HE Jacobs
name: B Biggs
name: AA Ilemobade
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Earlier research has underlined that household end-uses form building blocks of the residential water demand pattern. Numerous end-use studies have been presented in the past, but none have reported on shower end-uses at Universities in South Africa. This research focuses on shower water use, as part of the first detailed end-use field study conducted in South Africa. An extensive desktop study was conducted regarding South African end-uses, focusing on shower use. Shower flow rate was physically measured under different conditions, while actual shower duration for the same showers was derived from water temperatures recorded over two periods of 5 days each, at 1 min frequency. The changes in temperature were used to estimate actual shower duration and event start times. The total shower event volume was stochastically determined by using Monte Carlo analysis. The average shower duration of the 759 shower events identified as part of this study was 9 min and 33 sec, with a flow rate of 8.7 L/min. The average shower event volume was 83 L/event.
title: Data Stewardship Maturity Report for NOAA JPSS Ozone Mapping and Profiler Suite (OMPS) Total Column Ozone (V8TOz) Environmental Data Record (EDR)
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00246
Metabolic syndrome and relation of obesity indices to biomarkers of insulin sensitivity and inflammation among Qatari men and women: the Qatar Biobank Project
Creators: name: Nasralla, Eman Abdulwahhab
Publisher: name: Imperial College London
Year: 2015

description: Background: Increased body fatness along with other conditions typical of the metabolic syndrome (MetS) such as insulin resistance have become more prevalent in Qatar due to rapid transitions in the Qatari’s population lifestyle in the last few decades. The government of Qatar is seeking to improve the publics’ health; however, epidemiological studies on Qataris are limited. Aims: This research aims to 1) describe the features of the MetS and its determinants among a sample of Qataris, 2) explore the difference between four obesity subgroups regarding selected factors of metabolic health and 3) investigate the association of total and central body fatness indices with C-peptide and glycated haemoglobin A1c (HbA1c) as insulin sensitivity biomarkers and with fibrinogen as a biomarker of inflammation. Methods: This is a cross-sectional study of 879 Qatari men and women from the Qatar Biobank pilot phase. The MetS prevalence was estimated using the National Cholesterol Education Programme Adult Panel III (NCEP ATPIII), International Diabetes Federation (IDF) and the harmonised criteria. Metabolic health status for the four obesity subgroups (metabolically-healthy normal weight, metabolically-abnormal normal weight, metabolically-healthy obese and metabolically-abnormal obese) was identified using the harmonised guidelines. Multiple linear regression analyses were conducted to test the relation of the obesity indices (including body mass index, body fat percentage, waist circumference (WC) and waist-hip ratio) to C-peptide, HbA1c and fibrinogen. Results: The prevalence of the MetS was 18.4% (NCEP ATPIII), 27.0% (IDF), and 28.9% (harmonised definition). Central obesity was the most prevalent determinant of the MetS. There were significant differences in multiple factors of metabolic health for each of the four obesity subgroups. There were strong positive associations between the examined obesity indices and C-peptide, HbA1c and fibrinogen. WC had the strongest positive association with C-peptide, HbA1c and fibrinogen compared to the other examined body fatness indices. Conclusions: The current findings suggest that future interventions should target reducing WC in Qataris. The four obesity subgroups differed significantly regarding multiple factors of metabolic health; this implies that they might need to be treated differently. More epidemiological studies are needed to aid the Qatari government in their decision making to improve the publics’ health.
CCWi2017: F131 'A Python Tool for Generating Synthetic Demand Scenarios'
Creators: name: Santopietro, Simone
name: Granata, Francesco
name: Tricarico, Carla
name: Marinis, Giovanni De
name: Gargano, Rudy
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Demand modelling has a great impact on the outcome of hydraulic simulations of water distribution systems. Its stochastic nature has to be considered in order to obtain more reliable results. A stochastic approach, based on a mixed probability distribution, able to model residential water demand has been implemented in Python. This distribution considers both the event of null and not null water demand and allows to estimate the statistical parameters, solely on the number of supplied users and on the related average demand pattern. This approach is well suited to be used in hydraulic simulation workflows (e.g. using the EPANET toolkit) and a Python implementation could encourage a more refined demand characterization also in non-scientific environments.
A comprehensive epidemiological study of opisthorchiasis in a rural community of Thailand
Creators: name: Suwannahitatorn, Picha
Publisher: name: Imperial College London
Year: 2015

description: Opisthorchiasis is a zoonotic parasitic infection caused by human liver flukes. Opisthorchis viverrini (OV) is endemic in Southeast Asia along Mekong basin which estimated 9 million people are infected. Transmission to humans occurs through the consumption of uncooked fish; cyprinoid or white-scale freshwater fish containing infective stage metacercariae. The infection is mainly asymptomatic. Adult flukes could live up in the bile duct in the absence of treatment. Chronic infection is strongly related with bile duct cancer or cholangiocarcinoma. The International Agency for Research on Cancer has declared that Opisthorchis viverrini is a member of group 1 agent, carcinogenic to humans. Thailand has the highest incidence of cholangiocarcinoma in the world. However, opisthorchiasis is acknowledged as a neglected and underestimated disease on the global scale. In the present day, the epidemiological data on opisthorchiasis from OV infection in Thailand are considered outdated. An extensive cross-sectional study was undertaken from 1984 to 2001 under the National Control Program, but data on incidence is very limited. Moreover, infection dynamics are still poorly understood. This project aimed to comprehensively study the infection dynamics of OV infection using multiple tools in order to explore the infection in various aspects. Statistical models were developed to explore epidemiological data; prevalence, incidence and infection intensity, with risk factors for acquiring the infection. Infection dynamics will be described using mathematical modelling. The qualitative technique, by interviewing and group discussions, will be used to explain the cause of uncontrolled infection rate in bio-psycho-social aspect. Integrated study results will be used to develop community intervention strategies under the framework of the public health planning model. The overall outcome will be valuable for Thailand National Health Policy and epidemiological data will provide the basis for further rigorous academic research.
Die Vielfalt der Ideen überzeugt
Creators: name: Verkuil, Arie Hans
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2015
Subjects: subject: Innovation
subject: Unternehmenswettbewerb
subject: 650 - Management

description: «SWISSINNOVATION CHALLENGE» – Nach Abschluss der ersten Phase des Wettbewerbs ist Jury- Präsident Arie Hans Verkuil von der Anzahl und der Qualität der Innovationen begeistert.