cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
Creators: name: Jankovic, Sandra
name: Tsakiridou, Georgia
name: Ditzinger, Felix
name: Koehl, Niklas
name: Price, Daniel
name: Ilie, Alexandra Roxana
name: Kalantzi, Lida
name: Kimpe, Kristof
name: Holm, Rene
name: Nair, Anita
name: Griffin, Brendan
name: Saal, Christoph
name: Kuentz, Martin
Publisher: name: Wiley
Year: 2018
Subjects: enabling formulation
in silico prediction
poorly water-soluble drug
solubility parameter

description: Objectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water‐soluble drugs. Key findings An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid‐based delivery, solid dispersions and nano‐ or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug. Summary In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early‐stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour‐intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.
title: ADCO, Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Cart. 29 (G 134), 996 folios, f. 0575
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0575, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0575, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Animal Welfare Audits
Creators: name: Reynolds, Jim
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Consumers of dairy products look to veterinarians and producers to ensure humane care is provided to farm animals. Animal welfare is a consensus of opinions, and what is considered acceptable welfare, or husbandry, changes over time. Animal welfare can be assessed or described in three different approaches: animal bodies (physiologic, production, disease), animal natures (comparison to similar animals in nature) and animal minds (feelings, suffering). All three approaches should be considered when judging animal welfare. Audits are structured events so they can be repeatable and defendable. Auditors should have education in the given species and experience in the industry to evaluate different housing and management systems. The goal of an auditor is not to pass or fail the farm, but to determine if the agreed-on processes are being carried out. The auditor is verifying the welfare of the animals to consumers and retailers and is neutral to the farm. Training for auditors covers the welfare issues of the species, some industry standards, and how to perform an audit and comply with that company's requirements. The Professional Animal Auditor Certification Organization (PAACO) will certify the training of individual auditors and also the actual audit forms or processes of companies doing audits. PAACO will, in the future, provide training for people wanting to be certified to audit each species of farm animal, but who have not received training elsewhere.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Apoptosis, repair and senescence
Creators: name: Highmore, Roger
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: 60103 Cell Development, Proliferation and Death
subject: FOS: Biological sciences
subject: Cancer
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 111201 Cancer Cell Biology

description: We examine how an organism might use apoptosis, repair or senescence to deal with the threat posed by an errant cell. We consider risks and costs to the organism for each type of response and discuss how these evolve as the organism ages. We suggest how clusters of senescent cells may affect older organisms.
Instead of using a one-size-fits-all strategy to optimise the relationship between risk and cost, an organism might orchestrate an ensemble of strategies, each best suited to a particular situation. TP53 coding multiple isoforms may be part of such an approach, allowing responses to errant cells to vary with factors such as tissue type, kind of damage and time (age). In this view messages bearing environmental status information cause TP53 to express isoforms of P53 that best manage risk at particular locations and times.
If an organism’s response to damage is based on a compromise between risk and cost, an enhanced short-term response to damage can be induced by some combination of raising the assessed risk (e.g., by manipulating messages bearing information about the damage) and reducing the perceived cost (e.g., by manipulating messages that influence which isoforms of molecules such as P53 are expressed).
One way to counter the dangers posed by errant, 'repair in progress' and senescent cells is to facilitate production of new, substitute cells that can replace imperfect cells destroyed by apoptosis. Supplies of replacement cells might be eased by, e.g., introduction of new stem cells.
Post-breeding Treatments to lmprove Fertility in Lactating Dairy Cows
Creators: name: Sterry, R. A.
name: Welle, M. L.
name: Fricke, P. M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Lactating Holstein cows were assigned randomly to treatments to improve fertility after first postpartum timed artificial insemination (TAI). In Experiment 1, cows received no treatment (C; n = 223); a CIDR insert from five to 12 days after TAI (CIDR; n = 218); or 100 μg of genadotropin releasing hormone (GnRH) five days after TAI (G5; n = 227). In Experiment 2, cows received C (n = 160), G5 (n = 159), or treatment with 100 μg of GnRH seven days after TAI (G7; n = 163). Although treatment did not affect fertility, when data were combined to compare C (n = 383) and G5 (n = 386) treatments, pregnancies per AI (P/AI) tended to be greater for G5 (49.1 %) than C (45.8 %) cows, and this effect resulted from a GnRH treatment by cyclicity status interaction in which P/AI for anovular cows receiving G5 was greater than that for anovular C cows (45.5 vs. 31.1%). In conclusion, treatment with CIDR inserts after TAI had no effect on fertility, whereas treatment with GnRH five days after TAI improved fertility for anovular, but not for cycling cows.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Quantitative trait loci responsible for the difference in γ-oryzanol content in brown rice between japonica-type and indica-type rice cultivars
Creators: name: Kato, Tsuneo
name: Matsukawa, Tetsuya
name: Horibata, Akira
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: γ-Oryzanol is a main oleophilic component in rice bran oil and has been well recognized as a good dietary supplement for human health, as well as having uses in industrial materials. japonica-type rice cultivars generally showed significantly higher contents of total γ-oryzanol in brown rice compared with indica-type cultivars, although within-group variation was significant. The objective of this study was to explore quantitative trait loci (QTLs) responsible for the difference in the γ-oryzanol content between japonica-type and indica-type rice cultivars, using recombinant inbred lines (RILs), backcross inbred lines (BILs), and corresponding chromosome segment substitution lines (CSSLs) derived from crosses between japonica-type and indica-type. Results from RILs and BILs showed that eight QTLs were detected with R2 from .09 to .16. Nine candidate regions for QTL were also suggested from corresponding CSSLs. These QTLs from RILs and BILs and the candidate regions from CSSLs were not overlapped, although one QTLs was mapped near the boundaries of the respective candidate region. At four QTLs and three candidate regions, alleles or segments from japonica-type caused higher contents than those from indica-type. On the other hand, at the other four QTLs and six candidate regions, alleles or segments from indica-type caused higher contents than those from japonica-type, which is a reverse result to the parental differences. This result strongly suggested that alleles with increasing effects on γ-oryzanol content could be accumulated not only from japonica-type but also from indica-type, leading to a potential for increase in γ-oryzanol content in future breeding programs.
Sync Programs and Ultrasound
Creators: name: Fricke, Paul M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Early identification of non-pregnant dairy cows and heifers post-breeding can improve reproductive efficiency and pregnancy rate by decreasing the interval between artificial insemination (AI) services and increasing AI service rate. Thus, new technologies to identify non-pregnant dairy cows and heifers early after AI may play a key role in management strategies to improve reproductive efficiency and profitability on commercial dairy farms. Transrectal palpation is the oldest and most widely used method for early pregnancy diagnosis in dairy cattle7 • However, a newer technology may someday replace transrectal palpation as the method of choice for pregnancy diagnosis in the dairy industry. Before this transition can occur, two events must transpire. First, a technology must be developed that exceeds transrectal palpation in one or more of the characteristics of the ideal early pregnancy test. Second and no less important, this new technology must be practically integrated into a systematic, on-farm reproductive management strategy and empirically demonstrated to exceed the status quo of the industry (i.e., transrectal palpation) in reproductive performance. Results from a recent study indicate that positive pregnancy outcomes diagnosed by transrectal ultrasonography conducted 26 days after timed AI (TAI) may be inflated due to pregnancy loss, compared to pregnancy outcomes conducted 33 days after TAI. Furthermore, fertility to TAI after re-sychronization of ovulation was greater when initiated 33 days after TAI compared to 26 days. These results suggest the counterintuitive notion that delaying pregnancy diagnosis from 26 to 33 days post-TAI may improve reproductive efficiency when using a hormonal protocol for timed AI to program non-pregnant cows for rebreeding. This is due to the high rate of pregnancy loss occurring in cows diagnosed pregnant at 26 versus 33 days post-TAI.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Cash Flows of Instituting Reproductive Programs
Creators: name: Overton, Michael W.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Economic returns associated with improved reproductive performance in dairy herds depend upon a wide variety of factors, including initial level of reproductive performance, future value of milk and of the calves produced, cash cost of replacement heifers, and many other factors. A variety of synchronization programs have been developed that may help improve the overall pregnancy rate (PR) of the herd, but the profitability of each program varies. A spreadsheet model was designed to compare the potential profitability of an improved estrus-detection program, an estrus-detection program combined with presynchronization and a single timed insemination, and a program relying completely upon timed insemination. Each of these scenarios was compared to a baseline program based upon estrus-detection and AI. The baseline herd was designed to have an estrus-detection risk and conception risk of approximately 50% and 31%, respectively, consistent with herds at or slightly above average reproductive performance in the US. Each of the modeled scenarios predicted better future returns than the initial baseline program, but the two involving timed AI also incurred substantial costs upfront. Adoption of either of these programs carries significant potential risk if not properly implemented and managed. Poor compliance to either timed AI program dramatically decreases both the resulting PR and the predicted economic returns. Dairies that implement programs such as these should work diligently to ensure that compliance levels consistently exceed 90% in order to maximize the profitability of either approach.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Improving Decision Making by Consideration of Type I and Type II Error Costs
Creators: name: Overton, Michael W.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Dairy producers must make good decisions regarding potential new products or interventions in order to optimize profitability. Choosing to use a product that does not yield a profitable response is an example of a type I error. The concept of minimizing type I error cost by good decision making is usually intuitive. However, the concept of"lost opportunity cost" is a bit more nebulous. The choice of not using a product that in reality would have returned a profit is an example of a lost opportunity or a type II error cost. Calculation of the error costs for a single product with sound research is straightforward. Applying this concept to reproductive interventions is more problematic due to the difficulty in measuring the value of reproductive change. The model presented in this paper attempts to quantify the value of improved reproductive performance by estimating the value of the change in milk production, the value of calves produced, and the effects of culling changes. Application of type I and type II error theory to the question of "should TAI be used" yielded different results in the two examples. In the first scenario, the conclusion reached was that overall, herds with a baseline pregnancy rate (PR) of 16% or less utilizing AI based upon detection of estrus should carefully consider the use of TAI based on the large advantage of type II vs type I error costs. However, in scenario two, herds that have already achieved a PR of 17% have less to gain economically by making the reproductive management change.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Update on Parasite Control in Small Ruminants 2006
Creators: name: Kaplan, Ray M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Gastrointestinal nematode (GIN) parasites are the single most important health problem of sheep and goats. Traditionally, parasites have been controlled by frequent administration of anthelmintic drugs. However, the emergence of multiple-drug resistant parasites now threatens this paradigm of control and new approaches are required. Anthelmintics can no longer be thought of as an inexpensive management tool to be used as needed to maximize animal productivity. Instead anthelmintics must be thought of as extremely valuable and limited resources that should be used prudently. In response to this changing paradigm of anthelmintic use, new recommendations for parasite control have been proposed. The basis of this approach is to use the knowledge we have about the parasite, the animal, and the drugs to develop strategies that maximize the effectiveness of treatments while also decreasing the development of drug resistance. The term "Smart Drenching'' is often used to describe this approach to worm control. Due to the complexities ofinstituting such a program, successful implementation will only be possible with the help and active involvement of small ruminant veterinarians and other animal health professionals. Additionally, new innovative schemes using novel and sustainable approaches must be implemented. There are a number of new non-chemical technologies that will become increasingly important in GIN control programs both in the short and long term future. However, it is highly likely that any new technologies or developments in non-chemical GIN control methods will be less effective than chemical control has been (prior to emergence of drug resistant parasites). Therefore, as novel non-chemical control modalities become available and widely applied, anthelmintics will still be required for life-saving therapy when control fails. Unless veterinarians take an active and leading role in the education of small ruminant owners and help to implement these new approaches to parasite control, there may be no effective anthelmintics remaining when that time comes.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Arbeitsweise «integrierte Kollaborationsworkshops» (ICE-Sessions)
Creators: name: Beeler, Christian
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: BIM

description: Seit einigen Jahren werden Projekte mit der BIM-Methodik geplant. Fachkoordinatoren Gebäudetechnik haben die Pflicht Koordinationssitzungen zu Leiten und zu Protokollieren. Zusätzlich ist auch zu gewährleisten, dass der Datenaustausch geregelt ist und dass ein Projekt einen koordinierten Planungsstand aufweist, um zusätzliche Kosten in der Ausführungsphase zu vermeiden. Durch die neuen Methoden und Technologien, werden nicht nur DWG-Daten ausgetauscht, sondern es wird auch mit 3D-Fachmodellen gearbeitet.
Apoptosis, repair and senescence
Creators: name: Highmore, Roger
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: 60103 Cell Development, Proliferation and Death
subject: FOS: Biological sciences
subject: Cancer
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 111201 Cancer Cell Biology

description: We examine how an organism might use apoptosis, repair or senescence to deal with the threat posed by an errant cell. We consider risks and costs to the organism for each type of response and discuss how these evolve as the organism ages. We suggest how clusters of senescent cells may affect older organisms.
Instead of using a one-size-fits-all strategy to optimise the relationship between risk and cost, an organism might orchestrate an ensemble of strategies, each best suited to a particular situation. TP53 coding multiple isoforms may be part of such an approach, allowing responses to errant cells to vary with factors such as tissue type, kind of damage and time (age). In this view messages bearing environmental status information cause TP53 to express isoforms of P53 that best manage risk at particular locations and times.
If an organism’s response to damage is based on a compromise between risk and cost, an enhanced short-term response to damage can be induced by some combination of raising the assessed risk (e.g., by manipulating messages bearing information about the damage) and reducing the perceived cost (e.g., by manipulating messages that influence which isoforms of molecules such as P53 are expressed).
One way to counter the dangers posed by errant, 'repair in progress' and senescent cells is to facilitate production of new, substitute cells that can replace imperfect cells destroyed by apoptosis. Supplies of replacement cells might be eased by, e.g., introducing new stem cells. Fresh sources of substitute cells will encourage TP53 to express isoforms of P53 that mediate apoptosis.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0464
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0464, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0464, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Adaptive und maladaptive Bewältigungsstrategien im Umgang mit indirekter Unternehmenssteuerung
Creators: name: Meier, Gregory
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2016
Subjects: Indirekte Unternehmenssteuerung
Selbstgefährdung
Selbstführung
Erschöpfung
Arbeitsengagement

description: Aktuelle Studien weisen darauf hin, dass Stress bei Schweizer Erwerbstätigen in den letzten 10 Jahren deutlich zugenommen hat und in Zukunft zunehmen wird. Eine Erklärung dafür ist die fortschreitende Verbreitung der indirekten Steuerung, die häufig mit gesundheitsschädigender Selbstgefährdung (maladaptiv) einhergeht. Es ist deshalb notwendig, gesundheitsförderliche Strategien (adaptiv) aufzudecken, wobei die Selbstführung eine Alternative darstellt. Aus diesem Grund lautet die Fragestellung: Wie hängen Ausprägungen indirekter Steuerung, Selbstgefährdungs- und Selbstführungsstrategien mit der Gesundheit von Erwerbstätigen zusammen? Indirekt gesteuerte Erwerbstätige in der Schweiz (N = 496) wurden durch einen Fragebogen befragt, um mithilfe von Strukturgleichungsanalysen die Zusammenhänge zwischen den Konstrukten zu untersuchen. Es zeigt sich, dass die Belastungen zur Erschöpfung führen (β = 0.22**), wobei dieser Zusammenhang teilweise durch die Selbstgefährdung vermittelt wird (indirekter Effekt = 0.32**). Zudem wird ersichtlich, dass drei Selbstführungsstrategien den Zusammenhang zwischen den Ressourcen und Arbeitsengagement (β = 0.49***) teilweise mediieren (indirekter Effekt = 0.03**). Darüber hinaus zeigt sich ein sehr grosser negativer Zusammenhang zwischen den Belastungen und Ressourcen (β = -0.85**).
Apoptosis, repair and senescence
Creators: name: Highmore, Roger
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: 60103 Cell Development, Proliferation and Death
subject: FOS: Biological sciences
subject: Cancer
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 111201 Cancer Cell Biology
subject: 60114 Systems Biology

description: We examine how an organism might use apoptosis, repair or senescence to deal with the threat posed by an errant cell. We consider risks and costs to the organism for each type of response and discuss how these evolve as the organism ages. We suggest how clusters of senescent cells may affect older organisms.
Instead of using a one-size-fits-all strategy to optimise the relationship between risk and cost, an organism might orchestrate an ensemble of strategies, each best suited to a particular situation. TP53 coding multiple isoforms may be part of such an approach, allowing responses to errant cells to vary with factors such as tissue type, kind of damage and time (age). In this view messages bearing environmental status information cause TP53 to express isoforms of p53 that best manage risk at particular locations and times.
If an organism’s response to damage is based on a compromise between risk and cost, an enhanced short-term response to damage can be induced by some combination of raising the assessed risk (e.g., by manipulating messages bearing information about the damage) and reducing the perceived cost (e.g., by manipulating messages that influence which isoforms of molecules such as p53 are expressed).
One way to counter the dangers posed by errant cells is to facilitate production of new, substitute cells that can replace imperfect cells destroyed by apoptosis. Fresh sources of substitute cells will encourage TP53 to express isoforms of p53 that mediate apoptosis.
Organs within one body may coordinate and synchronise their risk horizons by exchanging messages through the bloodstream.Medical interventions might intercept and manipulate these blood-borne messages in attempts to eliminate particular threats, or to preserve resources for use later in life.
What is the current practice of therapists in the measurement of somatosensation in children with cerebral palsy and other neurological disorders?
Creators: name: Walmsley, Corrin
name: Taylor, Susan
name: Parkins, Timothy
name: Carey, Leeanne
name: Girdler, Sonya
name: Elliott, Catherine
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4201
subject: Allied health and rehabilitation science

description: Background/aim: Somatosensation is the ability to detect and recognise body sensations such as touch, vibration, pressure, pain, temperature and proprioception. Cerebral palsy is a neurological disorder that is often accompanied by impairments in somatosensation. Current somatosensory assessments have limited psychometrics established for use with these children. The aim of this study was to identify therapists’ current practice and perspectives related to the assessment of somatosensation in children with neurological disorders. Methods: A cross-sectional questionnaire was used to identify the somatosensory assessments currently used in clinical practice, time allocated to assessment, and therapists’ satisfaction and confidence using the available assessments of somatosensation. The questionnaire was adapted from a previously utilised questionnaire that identified therapists’ use of somatosensory assessments with adults post-stroke. Results: A total of 135 therapists responded to the questionnaire. Seventy-nine (92%) occupational therapists and 44 (89.7%) physiotherapists indicated that they currently assessed or treated children with somatosensory deficits. Sixty-four (82.1%) occupational therapists and 38 (86.3%) physiotherapists regarded assessment of somatosensation in children with neurological disorders as important to very important. However, only seven (8.8%) occupational therapists and seven (15.9%) physiotherapists reported confidence in their ability to do so. The methods with which therapists detect and measure somatosensory impairment in children with neurological disorders are variable, with non-standardised and/or informal assessments most frequently used. Conclusion: Despite there being recommendations of best practice for the assessment of specific domains of somatosensation in children with cerebral palsy, current practice does not yet mirror these recommendations. Additionally, therapists have low satisfaction and confidence with what they are currently using, highlighting the need for a comprehensive and standardised assessment of somatosensation for use in children with neurological disorders.
E-Democracy and the European Public Sphere
Creators: name: Hennen, L.
Publisher: name: Karlsruhe
Year: 2020

description: The chapter starts with an outline of outstanding recent contributions to the discussion of the EU democratic deficit and the so-called “no demos” problem and the debate about European citizenship and European identity—mainly in the light of insights from the EU crisis. This is followed by reflections on the recent discussion on the state of the mass media-based European public sphere. Finally, the author discusses the state of research on the Internet’s capacity to support the emergence of a (renewed) public sphere, with a focus on options for political actors to use the Internet for communication and campaigning, on the related establishment of segmented issue-related publics as well as on social media and its two-faced character as an enabler as well as a distorting factor of the public sphere. The author is sceptic about the capacities of Internet-based political communication to develop into a supranational (European) public sphere. It rather establishes a network of a multitude of discursive processes aimed at opinion formation at various levels and on various issues. The potential of online communication to increase the responsiveness of political institutions so far is set into practice insufficiently. Online media are increasingly used in a vertical and scarcely in a horizontal or interactive manner of communication.
The Spillover Effect
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2022
Subjects: subject: History
subject: Anthropology
subject: FOS: Sociology
subject: Archaeology
subject: Geography
subject: Sociology

description: That Karmaḷi held a different position than most of the other villages in the cluster is obvious in more than one way. The first is of course the plethora of temples that were found there; no other village had as complex a pantheon. Karmaḷi is supposed to have had one of the biggest temples on the island. Could that be the legacy of Mādhav Mantri’s ‘brāmhaṇisation’ that spilled over from Eḷa and Māṁcalāpur ? The catalogue of Museu Real da India Portuguesa lists two bold relief panels of Pārvati, one from one of the temples in Karmaḷi, and the other found in the orchard of Bom Jesus Basilica (Eḷa); Gomes Pereira lists the deity as Śrī Gajalakṣmi, which seems to be more accurate. [de Castro, 1907 : Cathalogo do Real Museu da India Portugueza, Oriente Portuguez, vol. 4, p 41] The second peculiarity of Karmaḷi is the constitution of its gāṁvkārī. While the gāṁvkārīs of Neura-O-Grande, Āzōśī and Dōṁgrī constituted of brāmhaṇ, those of Neura-o-Pequeno and Karmaḷi were made of cāḍḍī. That’s interesting; while the former abutted Gopakāpaṭṭan, the latter was adjacent to Eḷa (Old Goa).
Boletín Fármacos: Políticas 2024; 27(1)
Creators: name: Salud y Fármacos
name: Homedes, Nuria
name: Ugalde, Antonio
Publisher: name: Salud y Fármacos
Year: 2024
Subjects: Políticas de medicamentos
Políticas farmacéuticas
Políticas globales
América Latina
Europa y el Reino Unido
Canadá y EE UU
África
Organismos internacionales
Tratado pandémico

description: Boletín Fármacos es un boletín electrónico de la organización Salud y Fármacos (https://www.saludyfarmacos.org/) que se publica cuatro veces al año: febrero, mayo, agosto y noviembre.

El "Boletín Fármacos: Políticas" incluye información sobre evaluaciones de políticas de medicamentos, así como las políticas que están en discusión o que han adoptado diferentes países del mundo.

Este documento corresponde al 2024, Vol. 27, N°1
Digitale Qualitätssicherung in der Ausführung
Creators: name: Fässler, Andreas Charles
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: BIM

description: Die vorliegende Arbeit befasst sich mit den Prozessen und Vorgehensweisen der Qualitätssicherung während der Ausführungsphase eines Grossprojektes. Aus Sicht einer Totalunternehmung werden anhand eines laufenden Baustellenprojektes die firmeninternen Standardprozesse untersucht und nach Verbesserungsmöglichkeiten gesucht.
Apoptosis, repair and senescence
Creators: name: Highmore, Roger
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: 60103 Cell Development, Proliferation and Death
subject: FOS: Biological sciences
subject: Cancer
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 111201 Cancer Cell Biology
subject: 60114 Systems Biology

description: We examine how an organism might use apoptosis, repair or senescence to deal with the threat posed by an errant cell. We consider risks and costs to the organism for each type of response and discuss how these evolve as the organism ages. We suggest how clusters of senescent cells may affect older organisms.
Instead of using a one-size-fits-all strategy to optimise the relationship between risk and cost, an organism might orchestrate an ensemble of strategies, each best suited to a particular situation. TP53 coding multiple isoforms may be part of such an approach, allowing responses to errant cells to vary with factors such as tissue type, kind of damage and time (age). In this view messages bearing environmental status information cause TP53 to express isoforms of p53 that best manage risk at particular locations and times.
If an organism’s response to damage is based on a compromise between risk and cost, an enhanced short-term response to damage can be induced by some combination of raising the assessed risk (e.g., by manipulating messages bearing information about the damage) and reducing the perceived cost (e.g., by manipulating messages that influence which isoforms of molecules such as p53 are expressed).
One way to counter the dangers posed by errant cells is to facilitate production of new, substitute cells that can replace imperfect cells destroyed by apoptosis. Fresh sources of substitute cells will encourage TP53 to express isoforms of p53 that mediate apoptosis.
Organs within one body may coordinate and synchronise their risk horizons by exchanging messages through the bloodstream.Medical interventions might intercept and manipulate these blood-borne messages in attempts to eliminate particular threats, or to preserve resources for use later in life.
We suggest a model where diseased cells can be suppressed by suitable interplay between the kinetics of disease formation, apoptosis and replacement cell creation.
Français pour les bilingues 3e/4e: Ailleurs, au même instant …
Creators: name: Trommer, Bernadette
name: Egli, Mirjam
name: Oliveira, Marta
Publisher: name: Pädagogische Hochschule FHNW
Year: 2020
Subjects: subject: français
subject: bilingue
subject: école primaire
subject: 440 - Französisch, romanische Sprachen allgemein
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Die Lernparcours sind spezifische Materialien, um französischsprachige Kinder, die in der Deutschschweiz den Fremdsprachenunterricht Französisch auf der Primarstufe besuchen, angemessen zu fördern.
Membrane-supported liquid-liquid extraction. Where do we stand today?
Creators: name: Riedl, Wolfgang
Publisher: name: Wiley
Year: 2021
Subjects: Mass transfer model
Membrane-assisted liquid-liquid extraction
Membrane contactors

description: Thanks to advances in materials science and manufacturing technology, membranes are now available for stable liquid-liquid extraction processes. Rigorous calculation models can be used to calculate the membrane areas required for a specific separation task as well as to optimize the module design. Rapid tests can determine the basic suitability and kinetic parameters. Thus, the general requirements for exploiting the specific advantages of this separation technology in technical applications are fulfilled.
Intense rainfall and debris flows in the Lomond Hills, Fife, 11–12 August 2020
Creators: name: Kirkbride, M. P.
name: Black, A. R.
name: Brazier, V.
name: Pickering, B. S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Over the night of 11–12th August 2020, unusually intense convective rainfall triggered several debris flows along the Lomond Hills escarpment. Rainfall intensities locally exceeded an estimated 0.33% annual exceedance probability. Each debris flow had a different magnitude and physical character depending on the availability of water and sediment and the effectiveness of the vegetation buffer, such that similar-looking micro-catchments responded in different ways. The largest debris flow far exceeded the others in magnitude, extending over 1 km with a descent of 246 m and an estimated volume of c. 1500–3000 m3, causing damage to a forestry road. Debris was entrained from a gullied relict talus, including fallen trees and incision of Lateglacial glaciofluvial sand. Deposit sedimentology and morphology demonstrate an initial debris-flow surge probably happened early in the storm coinciding with the greatest runoff generation, followed by later fluvial incision and sediment reworking. This appears to be the largest such event in the Lomond Hills for more than 90 years and may be characteristic of the landscape response to projected increases in convective rainfall intensities in twenty-first century summers.
Gründung, Innovation, Nachfolge Aktuelle Perspektiven des Unternehmertums in der Nordwestschweiz
Creators: name: (:Unkn) Unknown
Publisher: name: edition gesowip
Year: 2018
Subjects: Change Management
Psychologischer Vertrag
John P. Kotter
Mitarbeitendeneinbezug

description: Im Essay "Change Management und der Psychologische Vertrag" wird der Versuch unternommen, die Erfordernisse einer situativ adäquaten und arbeitnehmerbedürfnisgerechten Weiterentwicklung des Psychologischen Vertrags in den Phasen eines organisationalen Change-Prozesses zu definieren. Entlang der Struktur von Kotters acht Schritte-Modell des Change Managements werden dabei die entsprechenden Aktivitäten zur Stabilisierung des Arbeitgeber-Arbeitnehmer-Verhältnisses bestimmt. Durch die komplementäre Ergänzung von Kotters Modell entsteht ein neuer Ansatz, welcher den Ansprüchen eines modernen Wertschätzungsmanagements entspricht.
Intense rainfall and debris flows in the Lomond Hills, Fife, 11–12 August 2020
Creators: name: Kirkbride, M. P.
name: Black, A. R.
name: Brazier, V.
name: Pickering, B. S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Over the night of 11–12th August 2020, unusually intense convective rainfall triggered several debris flows along the Lomond Hills escarpment. Rainfall intensities locally exceeded an estimated 0.33% annual exceedance probability. Each debris flow had a different magnitude and physical character depending on the availability of water and sediment and the effectiveness of the vegetation buffer, such that similar-looking micro-catchments responded in different ways. The largest debris flow far exceeded the others in magnitude, extending over 1 km with a descent of 246 m and an estimated volume of c. 1500–3000 m3, causing damage to a forestry road. Debris was entrained from a gullied relict talus, including fallen trees and incision of Lateglacial glaciofluvial sand. Deposit sedimentology and morphology demonstrate an initial debris-flow surge probably happened early in the storm coinciding with the greatest runoff generation, followed by later fluvial incision and sediment reworking. This appears to be the largest such event in the Lomond Hills for more than 90 years and may be characteristic of the landscape response to projected increases in convective rainfall intensities in twenty-first century summers.
Leg Movement Rate before and after a Caregiver-Provided Intervention for Infants at Risk of Developmental Disability: A Pilot Study
Creators: name: Rosales, Marcelo R.
name: Deng, Weiyang
name: Nishiyori, Ryota
name: Vanderbilt, Douglas L.
name: Smith, Beth A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Our purpose was to assess daily leg movement rate before and after a caregiver-provided in-home intervention for infants at risk for developmental disability. We also assessed adherence and quality of caregiver-child interaction. Twelve infants, at risk for developmental disabilities, and their caregivers participated in an intervention focused on increasing leg movements. Intervention started between 3- and 6-months corrected age and ended once the infant was able to sit independently or at 9 months corrected age, whichever occurred first. Infants were assessed monthly. Infants at risk for developmental disabilities who were moving less than 1200 leg movements per hour awake at the start of the intervention increased their daily leg movement rate following the intervention (Median [range]: pre-1047 [506–1056], post- 1104 [655–1359], p = 0.040). Additionally, the caregivers had a high adherence (Median: 89%, Range: 11.43%–329.17%) and good quality of caregiver-child interaction (Median NCAST total: 46, Range: 34–59); and maintained similar amounts of adherence (p = 0.575) and quality of caregiver-child interaction (p = 0.432) throughout the intervention. This study provides preliminary evidence that leg movement rate has the potential to be used as an outcome measure to assess an infant’s progress and motor practice during an intervention.
Therapists’ Perceptions of Participating in a Large Research Study: Benefits, Challenges, and Impact on Practice
Creators: name: Wynarczuk, Kimberly D.
name: Chiarello, Lisa A.
name: Jones, Kandis
name: Jeffries, Lynn
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Aims: Clinician participation in research is important to expand clinical research. However, there is limited understanding of the impact of such participation. The purpose of this survey-based study was to describe school-based physical therapists’ perceptions of the impact, benefits, and challenges of research participation. Methods: Participants were school-based physical therapists (n = 67) who had been research personnel in a year-long study. Participants completed a questionnaire regarding their experiences participating in the study. Results: Most therapists (59%) perceived that participating in the study improved their competency as a school-based PT a small extent. Participation impacted some therapists a moderate to a great extent in their student assessments (43%), decision-making (28%), and team collaboration (25%). Almost all therapists (96%) responded that they would participate in research again. Researchers identified three themes regarding benefits of participating in research: 1) research and promoting the growth of the profession, 2) support for and expansion of my school-based practice, and 3) reflective practitioner. Researchers identified four themes regarding challenges of participating in research: 1) administrative aspects; 2) time; 3) training; and 4) implementing the tools. Conclusions: Findings from this study support therapist participation in research, and have implications for clinicians, supervisors, and researchers.
Chaos oder Steuerung? Führung 4.0! Führungsperspektiven auf die mobil-flexible Zusammenarbeit mit dem Ziel eines produktiven Teams
Creators: name: Weichbrodt, Johann
name: Welge, Katrina
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: flexible Arbeit
mobil-flexibles Arbeiten
Führung

description: Führungsperspektiven auf die mobil-flexible Zusammenarbeit mit dem Ziel eines produktiven Teams
ВЛАДИМИР МАТВЕЕВИЧ ГЕССЕН И ЕГО ВЗГЛЯДЫ НА АДМИНИСТРАТИВНУЮ ЮСТИЦИЮ
Creators: name: Зайнутдинов Динар Рафаилович
Publisher: name: Историко-правовые проблемы: Новый ракурс
Year: 2021
Subjects: В.М. ГЕССЕН
ИНСТИТУТ АДМИНИСТРАТИВНОЙ ЮСТИЦИИ
АДМИНИСТРАТИВНЫЕ СУДЫ
ПАРЛАМЕНТАРИЗМ
ПРАВОВОЕ ГОСУДАРСТВО
ФЕВРАЛЬСКАЯ РЕВОЛЮЦИЯ 1917 ГОДА
ДИКТАТУРА ПРОЛЕТАРИАТА

description: Статья посвящена исследованию государственно-правовых воззрений Владимира Матвеевича Гессена (1868-1920 годы) в отношении развития института административной юстиции в революционной России. Важную роль в формировании его взглядов играли идеи парламентаризма, разделения властей, конституционализма и правового государства. Подчиненное положение судебной власти исполнительной, укрепили в нем убеждение, что административное направление судебной ветви власти должно развиваться в рамках обособленности и независимости. Особое внимание В.М. Гессеном уделял обеспечению и защите субъективных публичных прав граждан, посредством административного судопроизводства. Революционные события 1917 года предоставили России возможность войти в ряд стран, в которых были воплощены лучшие достижения либеральной демократической правовой мысли. Этот момент для развития российской государственности В.М. Гессен считал решающим. Он надеялся, что революционная эпоха позволить воплотить в жизнь и такой существенный элемент правового государства, как административное судопроизводство. В заключении работы проводится обобщенные выводы В.М. Гессена на возможность учреждения административной юстиции в советской России.