cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Berry phase jumps and giant nonreciprocity in Dirac quantum dots
Creators: name: Rodriguez-Nieva, Joaquin F.
name: Levitov, Leonid S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We predict that a strong nonreciprocity in the resonance spectra of Dirac quantum dots can be induced by the Berry phase. The nonreciprocity arises in relatively weak magnetic fields and is manifest in anomalously large field-induced splittings of quantum dot resonances which are degenerate at $B=0$ due to time-reversal symmetry. This exotic behavior, which is governed by field-induced jumps in the Berry phase of confined electronic states, is unique to quantum dots in Dirac materials and is absent in conventional quantum dots. The effect is strong for gapless Dirac particles and can overwhelm the $B$-induced orbital and Zeeman splittings. A finite Dirac mass suppresses the effect. The nonreciprocity, predicted for generic two-dimensional Dirac materials, is accessible through Faraday and Kerr optical rotation measurements and scanning tunneling spectroscopy.
description: 6 pages, 6 figures
(4124) Sarah [Kitchin]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Farmers' Marketing and Purchasing Cooperatives, 1863-1939
Creators: name: Elsworth, R. H.
name: Wanstall, Grace
name: Elsworth, R. H.
name: Wanstall, Grace
Publisher: name: Unknown
Year: 1941
Subjects: subject: Agribusiness
subject: Marketing
subject: FOS: Economics and business

description: Excerpts from the report: This report covers the findings from an examination of the records for the 26,192 marketing and purchasing associations in the files of the Farm Credit Administration as of December 31, 1939. The study is based entirely on the number of associations, as this is the only yard-stick available for the 77 years since the first of the living cooperatives was organized. Not so many data are available for the associations organized and discontinued prior to 1910, as statistically would be desirable. Nevertheless, it has been possible, by weaving the fragmentary material in with the complete records, to present what Is believed to be essentially a true picture, especially for the years since 1900.
Autologous HER2 CMV bispecific CAR T cells are safe and demonstrate clinical benefit for glioblastoma in a Phase I trial
Creators: name: Zhang, J.
name: Landi, D.
name: Ahmed, N.
name: Ghazi, A.
name: Hicks, J.
name: Diouf, O.
name: Kalra, M.
name: Hegde, M.
name: Gerken, C.
name: Wels, W.
name: Baskin, D.
name: Yi, Z.
name: Grossman, R.
name: Brawley, V.
name: Ashoori, A.
name: Gottschalk, S.
name: Wakefield, A.
name: Gee, A.
name: New, P.
name: Powell, S.
name: Kew, Y.
name: Rooney, C.
name: Bielamowicz, K.
name: Heslop, H.
name: Dotti, G.
Publisher: name: BioMed Central Ltd.
Year: 2015

description: Glioblastoma (GBM) remains incurable with current standard-of-care therapies. Adoptive T cell transfer holds the promise to improve outcomes for GBM patients. We report on the results of the Phase I clinical study, NCT01109095, administering autologous CMV.pp65 T cells grafted with a second generation HER2 chimeric antigen receptor (CAR) with a CD28.zeta signaling domain to patients with progressive GBM.

Seventeen CMV-seropositive patients with radiologically progressive HER2+ GBM were enrolled. The median age was 49 years (range 11 to 71; 6 children; 11 adults). Children enrolled had significantly larger tumor volumes at infusion. A cell product was successfully generated for all patients from a peripheral blood draw (maximum 90mL). A median of 67% (range: 46-82) of T cells expressed the HER2 CAR, and exhibited a median 985.5 (range 390 to 1292) CMV.pp65 reactivity in an IFN-γ Elispot assay (SFC/105 T cells). Infusions of 1x106/m2-1x108/m2 were well tolerated without severe adverse events or cytokine release syndrome. HER2 CMV T cells were detected in the peripheral blood for up to 12 weeks post infusion, as judged by rtPCR of a CAR-specific amplicon. Out of 16 evaluable patients, 8 had progressive disease, 8/16 patients had objective responses: 1 patient had a partial response with a ~62% reduction in tumor volume lasting 8 months, 7 patients had stable disease for more than 6 weeks (of these 5 were durable >10 weeks) and 3 subjects are currently with a follow up 24 to >30 months, after T cell infusion. The median survival was 11.6 months from infusion and 24.8 months from diagnosis. The median survival for adults was 30 months from diagnosis.

We conclude that systemically administered HER2 CAR CMV bispecific T cells are safe. A durable clinical benefit was observed in ~38% of patients.
Diagrammatic expansion for positive density-response spectra: Application to the electron gas
Creators: name: Uimonen, A. -M.
name: Stefanucci, G.
name: Pavlyukh, Y.
name: van Leeuwen, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In a recent paper [Phys. Rev. B 90, 115134 (2014)] we put forward a diagrammatic expansion for the self-energy which guarantees the positivity of the spectral function. In this work we extend the theory to the density response function. We write the generic diagram for the density-response spectrum as the sum of partitions. In a partition the original diagram is evaluated using time-ordered Green's functions (GF) on the left-half of the diagram, antitime-ordered GF on the right-half of the diagram and lesser or greater GF gluing the two halves. As there exist more than one way to cut a diagram in two halves, to every diagram corresponds more than one partition. We recognize that the most convenient diagrammatic objects for constructing a theory of positive spectra are the half-diagrams. Diagrammatic approximations obtained by summing the squares of half-diagrams do indeed correspond to a combination of partitions which, by construction, yield a positive spectrum. We develop the theory using bare GF and subsequently extend it to dressed GF. We further prove a connection between the positivity of the spectral function and the analytic properties of the polarizability. The general theory is illustrated with several examples and then applied to solve the long-standing problem of including vertex corrections without altering the positivity of the spectrum. In fact already the first-order vertex diagram, relevant to the study of gradient expansion, Friedel oscillations, etc., leads to spectra which are negative in certain frequency domain. We find that the simplest approximation to cure this deficiency is given by the sum of the zero-th order bubble diagram, the first-order vertex diagram and a partition of the second-order ladder diagram. We evaluate this approximation in the 3D homogeneous electron gas and show the positivity of the spectrum for all frequencies and densities.
description: 19 pages, 19 figures
(4125) William Lacey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Short-Rotation Coppice Willow: Soil Carbon Sequestration and Financial Incentives for Farmers
Creators: name: Atkinson, Rachel
Publisher: name: University of Liverpool Repository
Year: 2023

description: This thesis comprises a comprehensive study of Short Rotation Coppice (SRC) Willow (Salix), a second-generation bioenergy crop with the capacity to contribute towards environmental and renewable energy challenges. The research includes two integral components: a detailed research report and a scientific publication, both providing thorough information on SRC willow’s potential. 
The research report serves as a thorough literature review, providing a detailed overview of SRC willow including best planting practices to maximise yield, and an assessment of environmental benefits including soil carbon sequestration, biodiversity enhancement, water quality improvement, and flood management. Additionally, the report assesses the financial viability of cultivating SRC willow from the farmers’ perspective and examines past and existing policy frameworks and incentivisation schemes for the establishment of SRC willow. The findings emphasise the need for more robust policy support and financial incentives to promote SRC willow cultivation, aligning with ambitious climate targets.
The scientific publication focuses on the quantification of soil organic carbon (SOC) change following arable and grassland conversion to SRC willow. The study follows systematic review and meta-analysis protocols to synthesise the data from various studies, contributing to the understanding of SRC willow’s role in carbon sequestration and its potential to mitigate agricultural emissions. The meta-analysis revealed a significant overall increase in SOC with SRC willow conversion. However, high levels of heterogeneity were observed within and between studies so subgroup analyses were performed to identify any driving factors. Results indicated that prior land use was an important factor, with arable land conversions leading to SOC gains, while grassland shifts resulted in minor losses. Low initial carbon stocks correlated with higher SOC gains, whereas high initial stocks often saw limited or negative changes. These findings have implications for management practices when choosing where to establish SRC willow plantations. Additionally, age exhibited a slight negative correlation with SOC change, suggesting potential sequestration decline as plantations mature. The study also acknowledges limitations in existing research methodologies, such as reporting transparency, sampling depth, and experimental design. These limitations highlight the need for more rigorous and standardised approaches to comprehensively understand SOC dynamics within SRC willow systems.
Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: A Production Assistant for Cell Therapy (PACT) translational application
Creators: name: Gee, A.P.
name: Rollins, L.A.
name: Raghavan, D.
name: Leen, A.M.
name: Vera, J.F.
name: Sun, J.
name: Lapteva, N.
name: Hiregange, M.
name: Dotti, G.
name: Ballard, B.
name: Mamonkin, M.
name: Perna, S.K.
name: Omer, B.
name: Durett, A.G.
name: Myers, D.G.
name: Rooney, C.M.
name: Huye, L.E.
name: Brenner, M.K.
name: Dakhova, O.
Publisher: name: BioMed Central Ltd.
Year: 2015

description: Background: Virus-specific T-cells (VSTs) proliferate exponentially after adoptive transfer into hematopoietic stem cell transplant (HSCT) recipients, eliminate virus infections, then persist and provide long-term protection from viral disease. If VSTs behaved similarly when modified with tumor-specific chimeric antigen receptors (CARs), they should have potent anti-tumor activity. This theory was evaluated by Cruz et al. in a previous clinical trial with CD19.CAR-modified VSTs, but there was little apparent expansion of these cells in patients. In that study, VSTs were gene-modified on day 19 of culture and we hypothesized that by this time, sufficient T-cell differentiation may have occurred to limit the subsequent proliferative capacity of the transduced T-cells. To facilitate the clinical testing of this hypothesis in a project supported by the NHLBI-PACT mechanism, we developed and optimized a good manufacturing practices (GMP) compliant method for the early transduction of VSTs directed to Epstein-Barr virus (EBV), Adenovirus (AdV) and cytomegalovirus (CMV) using a CAR directed to the tumor-associated antigen disialoganglioside (GD2).Results: Ad-CMVpp65-transduced EBV-LCLs effectively stimulated VSTs directed to all three viruses (triVSTs). Transduction efficiency on day three was increased in the presence of cytokines and high-speed centrifugation of retroviral supernatant onto retronectin-coated plates, so that under optimal conditions up to 88% of tetramer-positive VSTs expressed the GD2.CAR. The average transduction efficiency of early-and late transduced VSTs was 55 ± 4% and 22 ± 5% respectively, and early-transduced VSTs maintained higher frequencies of T cells with central memory or intermediate memory phenotypes. Early-transduced VSTs also had higher proliferative capacity and produced higher levels of TH1 cytokines IL-2, TNF-α, IFN-γ, MIP-1α, MIP-1β and other cytokines in vitro.Conclusions: We developed a rapid and GMP compliant method for the early transduction of multivirus-specific T-cells that allowed stable expression of high levels of a tumor directed CAR. Since a proportion of early-transduced CAR-VSTs had a central memory phenotype, they should expand and persist in vivo, simultaneously protecting against infection and targeting residual malignancy. This manufacturing strategy is currently under clinical investigation in patients receiving allogeneic HSCT for relapsed neuroblastoma and B-cell malignancies (NCT01460901 using a GD2.CAR and NCT00840853 using a CD19.CAR).
A systematic study of carbon-oxygen white dwarf mergers: mass combinations for Type Ia supernovae
Creators: name: Sato, Yushi
name: Nakasato, Naohito
name: Tanikawa, Ataru
name: Nomoto, Ken'ichi
name: Maeda, Keiichi
name: Hachisu, Izumi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Mergers of two carbon-oxygen (CO) white dwarfs (WDs) have been considered as progenitors of Type Ia supernovae (SNe Ia). Based on smoothed particle hydrodynamics (SPH) simulations, previous studies claimed that mergers of CO WDs lead to an SN Ia explosion either in the dynamical merger phase or stationary rotating merger remnant phase. However, the mass range of CO WDs that lead to an SN Ia has not been clearly identified yet. In the present work, we perform systematic SPH merger simulations for the WD masses ranging from $0.5~M_{\odot}$ to $1.1~M_{\odot}$ with higher resolutions than the previous systematic surveys and examine whether or not carbon burning occurs dynamically or quiescently in each phase. We further study the possibility of SN Ia explosion and estimate the mass range of CO WDs that lead to an SN Ia. We found that when the both WDs are massive, i.e., in the mass range of $0.9~M_{\odot} {\le} M_{1,2} {\le} 1.1~M_{\odot}$, they can explode as an SN Ia in the merger phase. On the other hand, when the more massive WD is in the range of $0.7~M_{\odot} {\le} M_{1} {\le} 0.9~M_{\odot}$ and the total mass exceeds $1.38~M_{\odot}$, they can finally explode in the stationary rotating merger remnant phase. We estimate the contribution of CO WD mergers to the entire SN Ia rate in our galaxy to be of ${\lt} 9\%$. So, it might be difficult to explain all galactic SNe Ia by CO WD mergers.
description: 12 pages, 10 figures, accepted for publication in ApJ
New Itineraries for Agroecology Using Cooperative Robots
Creators: name: Lenain, Roland
name: Medici, Marco
name: Martinet, Philippe
Publisher: name: Zenodo
Year: 2023
Subjects: agroecology
agrobots
multi-task
coordination

description: Ninsar aims to develop robotic approaches for the implementation of new cultural practices, capable of acting as a lever for agroecological practices. Indeed, the deployment of the principles of agroecology on a large scale requires being able to act in a discriminated, precise and frequent way on crops. This implies the use of a workforce that is increasingly difficult to recruit, given the arduous nature of the associated work. Also, the use of robotic tools appears to be a promising lever, which should be developed. Nevertheless, the constraints in terms of productivity, precision, variability of the environment and cultures, require robotic capacities that are still immature, or difficult to reach by a single robot. Ninsar project then proposes to carry out ambitious research, based on the design of agroecological routes using a fleet of elementary robots, equipped with the capacity for cooperation and feedback with the environment. Such an approach, breaking with current developments, requires many advances, both in terms of the definition of new farming practices and robotic developments. The project will also develop innovative decision-making approaches dedicated to multi-robot systems, to adapt robotic behaviors to the diversity of actions required by agroecological practices. The project will rely primarily on experimental means implemented as a part of the Equipex+ Tirrex program (Roboterrium). It will also aim to integrate other advances in the field of agronomy, mechatronic design or human understanding of new technologies.This is made possible by its implementation, in connection with other actions, within the PEPR or the SADEA acceleration strategy. The benefits of this project will thus go beyond the strict framework of the development of innovative robotic systems for agriculture. Indeed, throughout its direct results, the progress made within Ninsar will allow short-term applications on the adaptation of current agricultural equipment and/or the implementation of new agroecological practices compatible with the growing maturity of new technologies. Ninsar will open up new research routes, at the interface between agronomy and robotics, providing solutions to the societal challenge of agroecological transition.
description: Poster presented at the WORLD FIRA, 7-9/02/2023, Toulouse, France. Project financed by ANR, dossier ANR-22-XXXX-00XX-12
(4127) Kate Laycock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Memefizierter Antisemitismus. Protest und antisemitische Projektion auf TikTok, Instagram & Co im Schatten des 7. Oktobers
Creators: name: Ebbrecht-Hartmann, Tobias
Year: 2024
Subjects: subject: 300 Sozialwissenschaften

description: Antisemitismus in sozialen Medien ist kein neues Phänomen. Auch wenn antisemitische Kommunikation auf Plattformen wie TikTok von der enormen Reichweite profitiert, die der Empfehlungsalgorithmus den Influencer:innen ermöglicht, handelt es sich doch in erster Linie um ein gesamtgesellschaftliches und globales Problem, das deshalb in sozialen Medien auftaucht, weil diese ein wesentlicher Bestandteil sozialer Lebenswelten geworden sind. Wie aber lassen sich antisemitische Kommunikation in sozialen Medien und andere Nutzungsformen wie Aktivismus und Protest unterscheiden? Wo verschwimmen die Grenzen? Diese Frage stellt sich im Hin-blick auf die Rolle, die soziale Medien und insbesondere Plattformen wie Instagram und TikTok vor und nach dem 7. Oktober 2023 bezüglich der globalen Intensivierung des Nahostkonflikts und der Verbreitung antisemitischer Bilder und Projektionen spielten. Auf Grundlage eines explorativen Verfahrens wurden für diese Untersuchung für Diskurse über den 7. Oktober und den Krieg in Gaza signifikante und symptomatische audio-visuelle Beiträge auf Instagram und TikTok identifiziert; sie werden mit dem Ziel einer Kategorisierung zur Bestimmung und Unterscheidung aktivistischer und antisemitisch motivierter Interventionen auf diesen Plattformen ausgewertet.
description: CARS Working Papers; 21
An Empirical Comparison of Multiple Imputation Methods for Categorical Data
Creators: name: Akande, Olanrewaju
name: Li, Fan
name: Reiter, Jerome
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Multiple imputation is a common approach for dealing with missing values in statistical databases. The imputer fills in missing values with draws from predictive models estimated from the observed data, resulting in multiple, completed versions of the database. Researchers have developed a variety of default routines to implement multiple imputation; however, there has been limited research comparing the performance of these methods, particularly for categorical data. We use simulation studies to compare repeated sampling properties of three default multiple imputation methods for categorical data, including chained equations using generalized linear models, chained equations using classification and regression trees, and a fully Bayesian joint distribution based on Dirichlet Process mixture models. We base the simulations on categorical data from the American Community Survey. In the circumstances of this study, the results suggest that default chained equations approaches based on generalized linear models are dominated by the default regression tree and Bayesian mixture model approaches. They also suggest competing advantages for the regression tree and Bayesian mixture model approaches, making both reasonable default engines for multiple imputation of categorical data. A supplementary material for this article is available online.
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
Creators: name: Caruana, I.
name: Savoldo, B.
name: Dotti, G.
name: Liu, H.
name: Hoyos, V.
name: Ittmann, M.M.
name: Kim, E.S.
name: Marchetti, D.
name: Weber, G.
Publisher: name: Nature Publishing Group
Year: 2015

description: Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors than in lymphoid malignancies. Although active tumor-mediated immunosuppression may have a role in limiting the efficacy of CAR-T cells, functional changes in T lymphocytes after their ex vivo manipulation may also account for the reduced ability of cultured CAR-T cells to penetrate stroma-rich solid tumors compared with lymphoid tissues. We therefore studied the capacity of human in vitro-cultured CAR-T cells to degrade components of the extracellular matrix (ECM). In contrast to freshly isolated T lymphocytes, we found that in vitro-cultured T lymphocytes lack expression of the enzyme heparanase (HPSE), which degrades heparan sulfate proteoglycans, the main components of ECM. We found that HPSE mRNA is downregulated in in vitro-expanded T cells, which may be a consequence of p53 (officially known as TP53, encoding tumor protein 53) binding to the HPSE gene promoter. We therefore engineered CAR-T cells to express HPSE and showed their improved capacity to degrade the ECM, which promoted tumor T cell infiltration and antitumor activity. The use of this strategy may enhance the activity of CAR-T cells in individuals with stroma-rich solid tumors.
Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors
Creators: name: Nishio, N.
name: Dotti, G.
Publisher: name: Taylor and Francis Inc.
Year: 2015

description: We improved the migration and survival of chimeric antigen receptor (CAR)-modified T cells in solid tumors by combining CAR-T cells with an armed oncolytic virus. Local delivery of the chemokine RANTES and the cytokine IL-15 by the oncolytic virus enhanced the trafficking and persistence of the CAR-T cells, resulting in improved antitumor effects.
Corrigendum: From Media Education to Digital Citizenship. Origins, perspectives and policy implementations in the school systems across Europe
Creators: name: Soriani, Alessandro
Publisher: name: Ricerche di Pedagogia e Didattica. Journal of Theories and Research in Education
Year: 2020

description: Ricerche di Pedagogia e Didattica. Journal of Theories and Research in Education, Vol 15, No 1 (2020)
Algebraic flow theory of infinite graphs
Creators: name: Miraftab, Babak
name: Moghadamzadeh, Javad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: A problem by Diestel is to extend algebraic flow theory of finite graphs to infinite graphs with ends. In order to pursue this problem, we define an A-flow and non-elusive H-flow for arbitrary graphs and for abelian topological Hausdorff groups H and compact subsets A of H. We use these new definitions to extend several well-known theorems of flows in finite graphs to infinite graphs.
Evaluation of intracellular signaling downstream chimeric antigen receptors
Creators: name: Karlsson, H.
name: Gigg, C.
name: Olsson-Strömberg, U.
name: Loskog, A.
name: Savoldo, B.
name: Jarvius, M.
name: Dotti, G.
name: Svensson, E.
Publisher: name: Public Library of Science
Year: 2015

description: CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G) CARs carrying CD28 or 4-1BB have been investigated in patients, preclinical studies suggest that third generation (3G) CARs with both CD28 and 4-1BB have enhanced capacity. However, little is known about the intracellular signaling pathways downstream of CARs. In the present work, we have analyzed the signaling capacity post antigen stimulation in both 2G and 3G CARs. 3G CAR T cells expanded better than 2G CAR T cells upon repeated stimulation with IL-2 and autologous B cells. An antigen-driven accumulation of CAR+ cells was evident post antigen stimulation. The cytotoxicity of both 2G and 3G CAR T cells was maintained by repeated stimulation. The phosphorylation status of intracellular signaling proteins post antigen stimulation showed that 3G CAR T cells had a higher activation status than 2G. Several proteins involved in signaling downstream the TCR were activated, as were proteins involved in the cell cycle, cell adhesion and exocytosis. In conclusion, 3G CART cells had a higher degree of intracellular signaling activity than 2G CARs which may explain the increased proliferative capacity seen in 3G CAR T cells. The study also indicates that there may be other signaling pathways to consider when designing or evaluating new generations of CARs.
Farmers' Cooperative Discontinuances, 1875-1939
Creators: name: Cochrane, W. W.
name: Elsworth, R. H.
name: Cochrane, W. W.
name: Elsworth, R. H.
Publisher: name: Unknown
Year: 1943
Subjects: subject: Agribusiness
subject: Financial Economics
subject: Marketing
subject: FOS: Economics and business

description: Excerpts from the report Summary: Cooperation as an economic technique does not fail as frequently as do the men and women who attempt to use this technique without knowledge of its limitations as well as its many possibilities. Their sins of commission and omission are many. The greatest of these is that they have not mastered the fundamental principles of cooperation nor schooled themselves sufficiently in the application of those principles. Another of their shortcomings is that they have not practiced the art of cooperating sufficiently to acquire a reasonable stock of cooperative experience. Despite the frailties of cooperators it is an established fact that the average length of life for the discontinued associations included in this study was approximately 10 years. The average period of activity for the 10,684 associations of record on the last day of December. 1942, was 20.5 years. The averages for some of the special groups were: Dairy products, including cheese factories, creameries, milk processing, and marketing associations, 27.7 years; grain, dry beans, and rice cooperatives, 26.2 years; livestock shipping associations and terminal-market sales agencies, 18.9 years; fruit, vegetable, and nut associations, 18.4 years; and associations handling wool and mohair, 17.3 years. The average for all marketing associations was 22.5 years. Such records discredit any idea that cooperation is a failure, even though some individuals may fall short. Farmer cooperation is a success and the immediate task is primarily that of orienting all would-be cooperators, whether they wish to market their crops or purchase their supplies through cooperative enterprises.
Data and MS search results of the COD-dipp worfklow.
Creators: name: BEDRAN, Georges
name: Alfaro, Javier
Publisher: name: figshare
Year: 2023
Subjects: Bioinformatics and computational biology not elsewhere classified

description: 1. pipeline_annotation_files.zip: Files necessary to run the workflow. 2. second-round-search_ncMAPs.bed: Genomic coordinates in BED format of the 8,601 identified and validated ncMAPs. 3. second_round_search_psm.tsv.gz: PSM information of the identified and validated canonical and non-canonical MAPs. 4. second-round-search_ncMAPs.tsv: PSM information of the 8,601 identified and validated ncMAPs. 5. HLA_Ligand_atlas_psm.tsv.gz: PSM information of the identified and validated canonical and non-canonical MAPs from HLA Ligand Atlas. 6. open-search_PTMs.tsv: PSM information of the open search annotated PTMs. 7. opensearch_PTMiner_filtered_FLR_HLA-I. tsv.gz: PSM information of open-search results with and without PTMs.
Fermion production during and after axion inflation
Creators: name: Adshead, Peter
name: Sfakianakis, Evangelos I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study derivatively coupled fermions in axion-driven inflation, specifically $m_ϕ^2ϕ^2$ and monodromy inflation, and calculate particle production during the inflationary epoch and the post-inflationary axion oscillations. During inflation, the rolling axion acts as an effective chemical potential for helicity which biases the gravitational production of one fermion helicity over the other. This mechanism allows for efficient gravitational production of heavy fermion states that would otherwise be highly suppressed. Following inflation, the axion oscillates and fermions with both helicities are produced as the effective frequency of the fermion field changes non-adiabatically. For certain values of the fermion mass and axion-fermion coupling strength, the two helicity states are produced asymmetrically, resulting in unequal number-densities of left- and right-helicity fermions.
description: 36 pages, 12 Figures
Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity
Creators: name: Ando, M.
name: Dotti, G.
name: Hoyos, V.
name: Ramos, C.A.
name: Yagyu, S.
name: Tao, W.
name: Brenner, M.K.
name: Bouchier-Hayes, L.
Publisher: name: Nature Publishing Group
Year: 2014

description: Delivery of suicide genes to solid tumors represents a promising tumor therapy strategy. However, slow or limited killing by suicide genes and ineffective targeting of the tumor has reduced effectiveness. We have adapted a suicide system based on an inducible caspase-9 (iC9) protein that is activated using a specific chemical inducer of dimerization (CID) for adenoviral-based delivery to lung tumors via mesenchymal stromal cells (MSCs). Four independent human non-small cell lung cancer (NSCLC) cell lines were transduced with adenovirus encoding iC9, and all underwent apoptosis when iC9 was activated by adding CID. However, there was a large variation in the percentage of cell killing induced by CID across the different lines. The least responsive cell lines were sensitized to apoptosis by combined inhibition of the proteasome using bortezomib. These results were extended to an in vivo model using human NSCLC xenografts. E1A-expressing MSCs replicated Ad.iC9 and delivered the virus to lung tumors in SCID mice. Treatment with CID resulted in some reduction of tumor growth, but addition of bortezomib led to greater reduction of tumor size. The enhanced apoptosis and anti-tumor effect of combining MSC-delivered Ad.iC9, CID and bortezomib appears to be due to increased stabilization of active caspase-3, as proteasomal inhibition increased the levels of cleaved caspase-9 and caspase-3. Knockdown of X-linked inhibitor of apoptosis protein (XIAP), a caspase inhibitor that targets active caspase-3 to the proteasome, also sensitized iC9-transduced cells to CID, suggesting that blocking the proteasome counteracts XIAP to permit apoptosis. Thus, MSC-based delivery of the iC9 suicide gene to human NSCLC effectively targets lung cancer cells for elimination. Combining this therapy with bortezomib, a drug that is otherwise inactive in this disease, further enhances the anti-tumor activity of this strategy.
Renato Foschi, Erica Moretti, Paola Trabalzini (a cura di), Il destino di Maria Montessori. Promozioni, rielaborazioni, censure, opposizioni al Metodo. Fefè Editore, Roma, 2019
Creators: name: Francini, Sandra
Publisher: name: Ricerche di Pedagogia e Didattica. Journal of Theories and Research in Education
Year: 2020

description: Ricerche di Pedagogia e Didattica. Journal of Theories and Research in Education, Vol 15, No 1 (2020)
(4120) Edward Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(4121) Susannah Janham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
From monoclonal antibodies to chimeric antigen receptors for the treatment of human malignancies
Creators: name: Diaconu, I.
name: Dotti, G.
name: Caruana, I.
Publisher: name: W.B. Saunders
Year: 2014

description: Monoclonal antibodies (mAbs) and their directly derived cell-based application known as chimeric antigen receptors (CARs) ensue from the need to develop novel therapeutic strategies that retain high anti-tumor activity, but carry reduced toxicity compared to conventional chemo- and radiotherapies. In this concise review article, we will summarize the application of antibodies designed to target antigens expressed by tumor cells, and the transition from these antibodies to the generation of CARs.
Two-Nucleon Higher Partial-Wave Scattering from Lattice QCD
Creators: name: Berkowitz, Evan
name: Kurth, Thorsten
name: Nicholson, Amy
name: Joo, Balint
name: Rinaldi, Enrico
name: Strother, Mark
name: Vranas, Pavlos M.
name: Walker-Loud, Andre
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a determination of nucleon-nucleon scattering phase shifts for l >= 0. The S, P, D and F phase shifts for both the spin-triplet and spin-singlet channels are computed with lattice Quantum ChromoDynamics. For l > 0, this is the first lattice QCD calculation using the Luscher finite-volume formalism. This required the design and implementation of novel lattice methods involving displaced sources and momentum-space cubic sinks. To demonstrate the utility of our approach, the calculations were performed in the SU(3)-flavor limit where the light quark masses have been tuned to the physical strange quark mass, corresponding to m_pi = m_K ~ 800 MeV. In this work, we have assumed that only the lowest partial waves contribute to each channel, ignoring the unphysical partial wave mixing that arises within the finite-volume formalism. This assumption is only valid for sufficiently low energies; we present evidence that it holds for our study using two different channels. Two spatial volumes of V ~ (3.5 fm)^3 and V ~ (4.6 fm)^3 were used. The finite-volume spectrum is extracted from the exponential falloff of the correlation functions. Said spectrum is mapped onto the infinite volume phase shifts using the generalization of the Luscher formalism for two-nucleon systems.
description: Added plots and expanded text to clarify discussions, particularly for extraction of the energies. Published version
Ricci-flat spacetimes admitting higher rank Killing tensors
Creators: name: Cariglia, Marco
name: Galajinsky, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: Ricci-flat spacetimes of signature (2,q) with q=2,3,4 are constructed which admit irreducible Killing tensors of rank-3 or rank-4. The construction relies upon the Eisenhart lift applied to Drach's two-dimensional integrable systems which is followed by the oxidation with respect to free parameters. In four dimensions, some of our solutions are anti-self-dual.
description: 12 pages
The immunogenicity of virus-derived 2A sequences in immunocompetent individuals
Creators: name: Heslop, H.E.
name: Brenner, M.K.
name: Abhyankar, H.
name: Liu, H.
name: Arber, C.
name: Savoldo, B.
name: Dotti, G.
Publisher: name: Nature Publishing Group
Year: 2013

description: Genetic engineering of T cells for adoptive immunotherapy in cancer patients has shown significant promise. To ensure optimal antitumor activity and safety, the simultaneous expression of multiple genes is frequently required, and short viral-derived 2A sequences are increasingly preferred for this purpose. Concerns exist, however, that these virus-derived sequences may induce unwanted immune responses, and thus diminish persistence of the gene-modified cells after adoptive transfer. Whereas such responses were absent in immunocompromised recipients, potential immunogenicity in immunocompetent individuals remains a concern. We now address whether ex vivo T cell responses can be elicited against the most widely used 2A sequences (2A-Thosea asigna virus (TAV) or 2A-equine rhinitis virus (ERAV), specifically) in immunocompetent individuals. We used a potent ex vivo culture system previously validated to induce T cell responses even against weakly immunogenic antigens. Of the sixteen donors tested, only five released very low levels of interferon-γ in response to 2A-TAV peptide mixtures (single peptide specificity in three donors, adjacent self-antigen peptide specificity in one donor and nonspecific reactivity in one donor). None of them produced cytotoxic activity or responded to 2A-ERAV. These results suggest that exposure to viral-derived 2A sequences is unlikely to produce unwanted T cell responses in immunocompetent individuals and further supports their continued use for studies of human gene therapy.
Leptonic CP Violation from a New Perspective
Creators: name: Emmanuel-Costa, David
name: Agostinho, Nuno Rosa
name: Silva-Marcos, J. I.
name: Wegman, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study leptonic CP violation from a new perspective. For Majorana neutrinos, a new parametrization for leptonic mixing of the form $V=O_{23} O_{12} K_{a}^{i}\cdot O$ reveals interesting aspects that are less clear in the standard parametrization. We identify several important scenario-cases with mixing angles in agreement with experiment and leading to large leptonic CP violation. If neutrinos happen to be quasi-degenerate, this new parametrization might be very useful, e.g., in reducing the number of relevant parameters of models.
description: 12 pages, 2 tables, 11 figures
Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease
Creators: name: Chakraborty, R.
name: Mahendravada, A.
name: Vera, J.F.
name: Heslop, H.E.
name: Savoldo, B.
name: Dotti, G.
name: Perna, S.K.
name: Rooney, C.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The low frequency of naturally occurring regulatory T cells (nTregs) in peripheral blood and the suboptimal protocols available for their ex vivo expansion limit the development of clinical trials based on the adoptive transfer of these cells. We have, therefore, generated a simplified, robust and cost-effective platform for the large-scale expansion of nTregs using a gas permeable static culture flask (G-Rex) in compliance with Good Manufacturing Practice. More than 109 putative Tregs co-expressing CD25 and CD4 molecules (92±5%) and FoxP3 (69±19%) were obtained within 21 days of culture. Expanded Tregs showed potent regulatory activity in vitro (80±13% inhibition of CD8+ cell division) and in vivo (suppression or delay of graft-versus-host disease in a xenograft mouse model) indicating that the cost-effective and simplified production of nTregs we propose will facilitate the implementation of clinical trials based on their adoptive transfer.
Chimeric antigen receptors (CARs) from bench-to-bedside
Creators: name: Dotti, G.
name: Savoldo, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chimeric antigen receptors (CARs) combine the antigen specificity of an antibody with the biologic properties of T lymphocytes. While the concept has been developed more than 20 years ago, only in recent years the clinical application of this approach has produced remarkable objective clinical responses. In this brief review, we outline some specific aspects that have led to antitumor responses in cancer patients.
TanCAR: A novel bispecific chimeric antigen receptor for cancer immunotherapy
Creators: name: Gottschalk, S.
name: Heslop, H.E.
name: Schönfeld, K.
name: Wels, W.S.
name: Koch, J.
name: Byrd, T.
name: Shaffer, D.R.
name: Ahmed, N.
name: Grada, Z.
name: Corder, A.
name: Baker, M.L.
name: Dotti, G.
name: Hegde, M.
name: Brawley, V.S.
name: Ghazi, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers simultaneously could result in better therapeutic efficacy. We created a functional chimeric antigen receptor-the TanCAR, a novel artificial molecule that mediates bispecific activation and targeting of T cells. We demonstrate the feasibility of cumulative integration of structure and docking simulation data using computational tools to interrogate the design and predict the functionality of such a complex bispecific molecule. Our prototype TanCAR induced distinct T cell reactivity against each of two tumor restricted antigens, and produced synergistic enhancement of effector functions when both antigens were simultaneously encountered. Furthermore, the TanCAR preserved the cytolytic ability of T cells upon loss of one of the target molecules and better controlled established experimental tumors by recognition of both targets in an animal disease model. This proof-of-concept approach can be used to increase the specificity of effector cells for malignant versus normal target cells, to offset antigen escape or to allow for targeting the tumor and its microenvironment.
Quantum annealing and non-equilibrium dynamics of Floquet Chern insulators
Creators: name: Privitera, Lorenzo
name: Santoro, Giuseppe E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Inducing topological transitions by a time-periodic perturbation offers a route to controlling the properties of materials. Here we show that the adiabatic preparation of a non-trivial state involves a selective population of edge-states, due to exponentially-small gaps preventing adiabaticity. We illustrate this by studying graphene-like ribbons with hopping's phases of slowly increasing amplitude, as for, e.g., a circularly polarized laser slowly turned-on. The induced currents have large periodic oscillations, but flow solely at the edges upon time-averaging, and can be controlled by focusing the laser on either edge. The bulk undergoes a non-equilibrium topological transition, as signaled by the local Chern marker introduced by Bianco & Resta in equilibrium. The failure of the adiabatic picture in presence of intraband resonances is discussed.
description: Revised version, improved discussion of resonant case, new clearer figures, improved presentation; 5 pages, 4 figures, plus supplementary material
IMOTHEP_D7.2_DisseminationSet_Website_VF
Creators: name: Favier, Peggy
name: Keranen, Jetta
Publisher: name: Zenodo
Year: 2020
Subjects: Dissemination tools, website creation, H2020 project, IMOTHEP, HEP

description: The deliverable D7.2: “Dissemination set-Website” describe the creation of several dissemination tools; poster, roll over, leaflet, website, etc. for the H2020 IMOTHEP project.