cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Research in Pancreatic Cancer: An Update After ASCO 2012
Creators: name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Pancreas; Pancreatic Neoplasms; Carcinoma; Therapeutics; /toxicity

description: Abstract not available
description: JOP. Journal of the Pancreas, Vol 13, N° 4 (2012): July - p. 330-469
The effect of vitamin D supplementation during pregnancy and lactation on maternal & infant 25-hydroxyvitamin D concentration
Creators: name: Chen, Nancy Nannan
Publisher: name: University of British Columbia
Year: 2013

description: BACKGROUND: Adequate vitamin D during pregnancy and lactation is important for optimal health of mother and infant. Due to low levels of vitamin D occurring in breast milk, exclusively breastfed infants are recommended by Health Canada to be supplemented with 400 IU/day of vitamin D. A potential solution to this is maternal vitamin D supplementation during pregnancy and lactation to raise maternal, infant serum 25-hydroxyvitamin D (25OHD) and breast milk vitamin D content. OBJECTIVE: To determine the effect of three dose regimens of supplemental vitamin D (400 IU/d, 1000 IU/d and 2000 IU/d) during pregnancy and lactation on maternal and infant 25-hydroxyvitamin D concentrations at 8 weeks post-partum. METHODS: In a double-blind, randomized controlled trial healthy pregnant women (n=226) between 13-24 weeks of gestation were recruited from Vancouver, Canada and randomized to take one of three doses of supplemental vitamin D3 (400 IU/d, 1000 IU/d or 2000 IU/d) until 8 weeks postpartum. Maternal blood was collected at baseline, 36 weeks gestation, and maternal and infant blood were collected 8 weeks postpartum. RESULTS: Mean 25OHD was 66 nmol/L at baseline and 21% of participants had a 25OHD < 50 nmol/L. At 8 weeks postpartum, maternal serum 25OHD concentrations [mean (95% CI)] were highest in the 2000 IU/d [87 (83, 90) nmol/L] followed by the 1000 IU/d [78 (74,81) nmol/L] and the 400 IU/d [69 (66, 73) nmol/L] group using intent to treat analysis. Likewise, at 8 weeks serum 25OHD concentrations were highest in infants whose mothers received 2000 IU/d [75 (67, 83 nmol/L)] followed by the 1000 IU/d [52 (45, 58) nmol/L] and the 400 IU/d [45 (38,52) nmol/L]. CONCLUSION: Maternal vitamin D supplementation of 2000 IU/d during pregnancy and lactation was found to be protective against vitamin D deficiency in infants for the first two months after birth. Generally, vitamin D supplementation increased maternal and infant 25OHD concentrations in a dose response manner.
Gauge Interaction as Periodicity Modulation
Creators: name: Dolce, Donatello
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Physics (physics.gen-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The paper is devoted to a geometrical interpretation of gauge invariance in terms of the formalism of field theory in compact space-time dimensions [arXiv:0903.3680]. In this formalism, the kinematic information of an interacting elementary particle is encoded on the relativistic geometrodynamics of the boundary of the theory through local transformations of the underlying space-time coordinates. Therefore, gauge interaction is described as invariance of the theory under local deformations of the boundary, the resulting local variations of field solution are interpreted as internal transformations, and the internal symmetries of the gauge theory turn out to be related to corresponding local space-time symmetries. In the case of local infinitesimal isometric transformations, Maxwell's kinematics and gauge invariance are inferred directly from the variational principle. Furthermore we explicitly impose periodic conditions at the boundary of the theory as semi-classical quantization condition in order to investigate the quantum behavior of gauge interaction. In the abelian case the result is a remarkable formal correspondence with scalar QED.
description: 37 pages, 2 figures. Version published in Annals of Physics (2012). New title, comments and minor corrections
Mesoserica Brenske 1898
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Mesoserica

description: Mesoserica Brenske, 1898c (not Mesoserica Matsumura, 1911)
[1 species].
Type species Mesoserica transvaalensis Brenske, 1902, by subsequent monotypy.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 144, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
title: Nützlichkeit und Effektivität
title: Orientierungen von Studierenden im Umgang mit digitalen Medien in der wissenschaftlichen Weiterbildung. Forschungsberich
titleType: Subtitle
Creators: name: Damm, Christoph
name: Dörner, Olaf
name: Fromme, Johannes
name: Hennig, Deborah
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2019
Subjects: Weiterbildungsforschung
Wissenschaftliche Weiterbildung
Offene Hochschule
Weiterbildendes Studium
Digitalisierung
nicht-traditionell Studierende
elektronische Medien
Gruppendiskussion
Dokumentarische Methode
Supportstrukturen

description: Die Herausforderungen durch gesellschaftliche Veränderungen aufgrund von Digitalisierung werden derzeit breit diskutiert, u.a. auch im Hinblick auf die Bereiche Bildung und Weiterbildung. Der verstärkte Einsatz digitaler Medien soll zu einer Modernisierung des Bildungswesens beitragen und u.a. flexiblere und selbstgesteuerte Lernprozesse und Bildungsverläufe eröffnen. Damit verbindet sich die Hoffnung, jenen Zielgruppen von Hochschulen besonders entgegen kommen zu können, die berufsbegleitend studieren oder neben dem Studium Kinder betreuen, und deren Lebenssituation sich somit von jener traditioneller Vollzeitstudierender unterscheidet. Die im vorliegenden Band dokumentierte qualitativ-empirische Studie verfolgte das Ziel, Erfahrungen und konkrete Umgangsweisen mit digitalen Medien von Studierenden in berufsbegleitenden Weiterbildungsstudiengängen zu untersuchen. Die Untersuchung geht davon aus, dass die Nutzung digitaler Medien auf der Grundlage von praxisgebundenen Erfahrungen, Erwartungen und Einstellungen im Zusammenhang mit elektronischen bzw. digitalen Medien erfolgt. In den durchgeführten Gruppendiskussionen zeigt sich, dass der Einsatz von digitalen Medien, insbesondere von Lernplattformen in weiterbildenden Studiengängen üblich ist und deren Nutzung auch von den Studierenden erwartet wird. Allerdings erfolgt die Nutzung solcher Technologien nur bedingt im (didaktischen) Sinne der Studiengangsleitungen und entspricht auch nicht den programmatischen Hoffnungen, die mit der Digitalisierung im Bildungsbereich verbunden sind. Wenn sie genutzt werden, dann sind sie vor allem für die effektive Organisation und Absolvierung des Studiums von Bedeutung.
description: Beiträge zur Weiterbildungsforschung; Bd. 2
Highlights on the First Line Treatment of Metastatic Pancreatic Cancer
Creators: name: Gunturu, Krishna S
name: Jarboe, Jamie
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Drug Therapy; gemcitabine; Neoplasm Metastasis; Pancreatic Neoplasms

description: Pancreatic cancer is the fourth leading cause of cancer deaths in men and women. The estimated deaths from pancreatic cancer in 2012 in the United States are 37,390, and the five-year survival for all patients with pancreatic adenocarcinoma is less than 5%. Majority of patients present with incurable metastatic pancreatic cancer. The 2012 American Society of Oncology (ASCO) Annual Meeting offered new insights into metastatic pancreatic cancer and we discuss Abstracts #4018, #4019, #4022, #4042, #4043, #4048, #4050 and comment on them in this paper.
description: JOP. Journal of the Pancreas, Vol 13, N° 4 (2012): July - p. 330-469
Soliton solutions for the Laplacian coflow of some $G_2$-structures with symmetry
Creators: name: Karigiannis, Spiro
name: McKay, Benjamin
name: Tsui, Mao-Pei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C44

description: We consider the Laplacian "co-flow" of $G_2$-structures: $\frac{d}{dt} ψ= - Δ_d ψ$ where $ψ$ is the dual 4-form of a $G_2$-structure $ϕ$ and $Δ_d$ is the Hodge Laplacian on forms. This flow preserves the condition of the $G_2$-structure being coclosed ($dψ=0$). We study this flow for two explicit examples of coclosed $G_2$-structures with symmetry. These are given by warped products of an interval or a circle with a compact 6-manifold $N$ which is taken to be either a nearly Kähler manifold or a Calabi-Yau manifold. In both cases, we derive the flow equations and also the equations for soliton solutions. In the Calabi-Yau case, we find all the soliton solutions explicitly. In the nearly Kähler case, we find several special soliton solutions, and reduce the general problem to a single \emph{third order} highly nonlinear ordinary differential equation.
description: 18 pages, no figures. Version 2: Minor improvements and addition of references. To appear in Differential Geometry and its Applications
Mesotrochalus Kolbe 1914
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Mesotrochalus

description: Mesotrochalus Kolbe, 1914
[2 species].
Type species Mesotrochalus docilis Kolbe, 1914, by subsequent designation of Ahrens (2007a).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 144, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Update on Novel Therapies for Pancreatic Neuroendocrine Tumors
Creators: name: Oberstein, Paul Eliezer
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Drug Therapy; everolimus; Neuroendocrine Tumors; Pancreatic Neoplasms; sunitinib; Vascular Endothelial Growth Factors

description: Neuroendocrine tumors (NETs) describe a heterogeneous group of tumors with a wide range of morphologic, functional, and behavioral characteristics. Pancreatic neuroendocrine tumors (pNET) are a subset of NETs which are increasing in incidence and prevalence. These tumors are generally slow growing and behave in an indolent fashion. However, when these tumors spread they can be life threatening and difficult to treat with current modalities. In 2011, the landscape of treatment for pNET was changed with the approval of two targeted agents, sunitinib and everolimus, the first new therapies for this disease in over 20 years. Data from these clinical trials and extensive preclinical work into the underlying molecular pathways in neuroendocrine tumors has generated intense interest in the quest to identify additional effective agents in this challenging disease. At the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting, several researchers presented updated data regarding the use of targeted agents, alternative chemotherapeutic agents and combinations of these in the treatment of pNET. Corrie et al. (Abstract #4121) reported data from a chemotherapy clinical trial replacing 5-FU with capecitabine and evaluating the addition of cisplatin in NETs. Several authors reviewed the addition of the anti VEGF monoclonal antibody bevacizumab into combination therapy. Ducreux et al (Abstract #4036) presented results from a trial of chemotherapy plus bevacizumab while Firdaus et al. (Abstract #4127) reported the results of combination therapy with octreotide, bevacizumab, and pertuzumab. Hobday et al. (Abstract #4048) reported positive results of an interim analysis of combination therapy with an mTOR inhibitor and bevacizumab. Kulke et al (Abstract #4125) reported the results of a clinical trial utilizing an antibody targeting the insulin growth factor receptor. Finally, Vinik et al. (Abstract #4118) provided updated survival data form the seminal phase III trial that led to approval of sunitinib in the treatment of pNET. The authors review and summarize these abstracts in this article.
description: JOP. Journal of the Pancreas, Vol 13, N° 4 (2012): July - p. 330-469
25 years of gender mainstreaming in Jordan : evolution and progress
Creators: name: Attia, Abby Michelle
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Gender mainstreaming
Jordan
Gender policy
Women's policy
International development
Middle East and North Africa
Beijing Platform for Action

description: Since the Beijing Platform for Action in 1995, countries have taken many approaches to gender mainstreaming. Gender mainstreaming policies were created to be context specific to account for the variety of ways that policy can promote gender equality. However, the variety of gender mainstreaming approaches today limits researchers and practitioners’ ability to measure or compare their impact. Governments’ gender mainstreaming policies have evolved as policy makers learn from the best practices of other countries. This requires in-depth case studies on their program’s implementation and impacts. This case study on Jordan’s gender mainstreaming policies and its evolution in the last 25 years explores how Jordan’s gender policies were impacted by the Beijing Platform and have evolved since then. Although Jordanian women have made remarkable gains in their life expectancies and education statuses in the last 25 years, their participation in public life continues to be limited. In this paper I use primary source analysis of Jordan’s gender mainstreaming policies, its program records, and historical research of Jordanian feminist organizations to understand how the Jordanian government has negotiated its gender mainstreaming policies to address the demands of different sectors of society. Although Jordan is a monarchy, Royal family must still negotiate the demands of the parliament, tribes, Islamic political parties, and the military. The Royal family’s patronage of gender mainstreaming policies has often pitted them against those interests. This paper explores how gender mainstreaming policies have been shaped by those domestic interests as well as pressure from international donors and feminist organizations. I argue that these competing interests have led to gender mainstreaming policies that are gender aware and targeted but have yet to be transformative. This paper offers analysis of how Jordan can continue its progress and transformation in gender policies in the next 25 years.
Solution to Bethe-Salpeter equation via Mellin-Barnes transform
Creators: name: Allendes, Pedro
name: Kniehl, Bernd
name: Kondrashuk, Igor
name: Cuello, Eduardo A. Notte
name: Medar, Marko Rojas
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider Mellin-Barnes transform of triangle ladder-like scalar diagram in d=4 dimensions. It is shown how the multi-fold MB transform of the momentum integral corresponding to an arbitrary number of rungs is reduced to the two-fold MB transform. For this purpose we use Belokurov-Usyukina reduction method for four-dimensional scalar integrals in the position space. The result is represented in terms of Euler psi-function and its derivatives. We derive new formulas for the MB two-fold integration in complex planes of two complex variables. We demonstrate that these formulas solve Bethe-Salpeter equation. We comment on further applications of the solution to the Bethe-Salpeter equation for the vertices in N=4 supersymmetric Yang-Mills theory. We show that the recursive property of the MB transforms observed in the present work for that kind of diagrams has nothing to do with quantum field theory, theory of integral transforms, or with theory of polylogarithms in general, but has an origin in a simple recursive property for smooth functions which can be shown by using basic methods of mathematical analysis.
description: 33 pages, 9 figures, revised version, all the factors and symbols of integration are written explcitly, symbols of proportionality are removed, section 2 is extended, section 6.3 is shortened
Update on Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors
Creators: name: Oberstein, Paul Eliezer
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Biological Markers; Neoplastic Cells, Circulating; Neuroendocrine Tumors; Pancreatic Neoplasms; placenta growth factor

description: Neuroendocrine tumors (NETs) describe a heterogeneous group of tumors with a wide range of morphologic, functional, and behavioral characteristics. These tumors are often indolent but they have the potential to cause symptoms through release of hormones and through local or distant spread. Pancreatic neuroendocrine tumors (pNET) represent a subset of NETs and they have a unique pattern of symptoms and disease progression. Due to the heterogeneity of this disease it is important to identify reliable markers to help guide prognosis and predict response to therapy. The recent approval of two new agents in the treatment of advanced pNET has raised additional interest in the significance of molecular markers in this disease. At the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting, several investigators reported on collaborative efforts to develop clinically useful biomarkers for this disease. Choti et al. (Abstract #4126) reported data about the functional characteristics of NETs and pNETs among a multi-institutional cohort finding that a substantial minority of patients have functional symptoms even when the disease is localized. Faggiano et al. (Abstract #1604) looked at a wide spectrum of NETs in several referral centers and reported on predictors of both short term and long term survival in this setting. Yao et al. (Abstract #4014) reported analysis of predictive biomarkers among patients in the RADIANT-2 trial which looked at the role of the mTOR inhibitor, everolimus compared to placebo in NET. Fischer et al. (Abstract #4128) looked at a novel biomarker, placental growth factor (PlGF) and evaluated the role of serum and tissue levels of this protein as a predictive marker. Finally, Khan et al. (Abstract #4123) investigated the role of circulating tumor cells in NET (and pNET) and found that this may have potential as a prognostic marker and an early marker of response to therapy. The authors review and summarize these abstracts in this article.
description: JOP. Journal of the Pancreas, Vol 13, N° 4 (2012): July - p. 330-469
Antioxidants for Intractable Pain in Chronic Pancreatitis Patients. Is the End of the Story?
Creators: name: Pezzilli, Raffaele
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Analgesia; Antioxidants; Pain Measurement; Pancreatitis, Chronic; Quality of Life

description: JOP. Journal of the Pancreas, Vol 13, N° 4 (2012): July - p. 330-469
Microserica Brenske 1894
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Microserica

description: Microserica Brenske, 1894a, as Serica (Microserica)
[142 species].
Type species Serica (Microserica) malaccensis Brenske, 1894, by monotypy.
Status revised to Microserica by Medvedev (1952).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 145, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Microsericaria Nikolajev 1979
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Microsericaria

description: Microsericaria Nikolajev, 1979
[5 species].
Type species Microserica quadripunctata Brenske, 1896, by original designation.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 145, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Posterior Consistency via Precision Operators for Bayesian Nonparametric Drift Estimation in SDEs
Creators: name: Pokern, Y.
name: Stuart, A. M.
name: van Zanten, J. H.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We study a Bayesian approach to nonparametric estimation of the periodic drift function of a one-dimensional diffusion from continuous-time data. Rewriting the likelihood in terms of local time of the process, and specifying a Gaussian prior with precision operator of differential form, we show that the posterior is also Gaussian with precision operator also of differential form. The resulting expressions are explicit and lead to algorithms which are readily implementable. Using new functional limit theorems for the local time of diffusions on the circle, we bound the rate at which the posterior contracts around the true drift function.
Kambrium-Vendi töörühma välipäevik 25
Creators: name: Pirrus, Enn
name: Mens, Kaisa
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1978
Subjects: Cambrian
geological descriptions

description: Field notebook with descriptions of Cambrian outcrops in Leningrad oblast (first in 1968, comments 1978)
Microtrochalus Brenske 1900
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Microtrochalus

description: Microtrochalus Brenske, 1900b
[3 species].
Type species Microtrochalus bipunctatus Brenske, 1902 (= Microtrochalus plagiger (Péringuey, 1892)), by subsequent monotypy.
Note: Péringuey (1902) incorrectly spelt Microtrochalus as “ Microtrachelus ”.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 145, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Microtubules immuno-labeled with Alexa 647 with widefield images 50-54
Creators: name: SINGH, Manish
Publisher: name: Zenodo
Year: 2021
Subjects: shareloc.xyz
shareloc.xyz:dataset
dstorm
u373
microtubules
alexa-647
indirect-immuno-labeling
alpha-tubulin
2d
em-ccd
thunderstorm
gluox
pfa+gluta
smlm

description: Open in Shareloc.XYZ

description: dSTORM images of microtubules with widefield images, Alpha-tubulin immuno-labeled with Alexa 647 in U373 cells, reconstructed by ThunderSTORM plugin (Uploaded via https://shareloc.xyz)
Morphological and Functional Alterations of Small Intestine in Chronic Pancreatitis
Creators: name: Gubergrits, Natalya Borisovna
name: Linevskiy, Yuri V
name: Lukashevich, Galina M
name: Fomenko, Pavel G
name: Moroz, Tatyana V
name: Mishra, Tapan
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Blind Loop Syndrome; Enteritis; Pancreatitis, Chronic; Digestion; Enzymes; Absorption

description: Context The small intestine in chronic pancreatitis has not been investigated yet thoroughly. It would be important to understand fat metabolism in the course of this disease and could be explained if the small intestine has some pathological conditions and, due to this reason, pancreatic enzyme substitution does not work in all patients. Objective To investigate the pathophysiology of small intestine in chronic pancreatitis and to show the reason why in some cases pancreatic enzyme substitution does not work properly. Patients In the process of the study 33 chronic pancreatitis patients have been examined. Controls The control group includes 30 subjects without chronic pancreatitis similar for age, sex and alcohol consumption to the patients with chronic pancreatitis patients. Investigations Aspiration biopsy of jejunum mucosa followed by histological examination and investigation of intestinal enzymes by aspiration has been performed. Main outcome measures Metabolism at membranic level has been studied by enzymatic activity of amylase and lipase in the small intestine. Production of enzymes (monoglyceride lipase, lactase, saccharase, maltase, glycyl-l-leucine dipeptidase) promoting metabolism in enterocytes has been estimated as to their activity in homogenates of jejunum mucosa samples. Participation of mucosa in intestinal digestion has been assessed by alkaline phosphatase activity in a secretory chyme from proximal portion of jejunum. Absorptive capacity of jejunum was evaluated by D-xylose test results. DNA, lysozyme, immunoglobulin contents of chyme have also been calculated and bacteriological study of chyme has been also performed. Results Secondary enteritis, accompanied by moderate dystrophic changes of mucous membrane, thinning of limbus, and decrease of Paneth cell mitotic index, was found to occur in chronic pancreatitis patients. Enteritis is followed by changes in enzymatic processes in the sphere of membrane and intestinal digestion, decrease of absorption, accelerated desquamation of epithelium, fall in local immunity and development of bacterial overgrowth syndrome. Conclusions Existence of secondary enteritis and bacterial overgrowth syndrome validates lack of enzyme replacement therapy efficacy in some chronic pancreatitis patients with pancreatic insufficiency. To optimize treatment in such cases it is important to perform small intestine decontamination and escalate enzyme preparation dosage.
description: JOP. Journal of the Pancreas, Vol 13, N° 5 (2012): September - p. 470-547
Grothendieck ring of semialgebraic formulas and motivic real Milnor fibres
Creators: name: Georges, Comte
name: Goulwen, Fichou
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14P10

description: We define a Grothendieck ring for basic real semialgebraic formulas, that is for systems of real algebraic equations and inequalities. In this ring the class of a formula takes into consideration the algebraic nature of the set of points satisfying this formula and contains as a ring the usual Grothendieck ring of real algebraic formulas. We give a realization of our ring that allows to express a class as a Z[1/2]- linear combination of classes of real algebraic formulas, so this realization gives rise to a notion of virtual Poincaré polynomial for basic semialgebraic formulas. We then define zeta functions with coefficients in our ring, built on semialgebraic formulas in arc spaces. We show that they are rational and relate them to the topology of real Milnor fibres.
description: 30 pages, 1 figure
Effects of Porcine Pancreatic Enzymes on the Pancreas of Hamsters. Part 2: Carcinogenesis Studies
Creators: name: Nozawa, Fumiaki
name: Yalniz, Mehmet
name: Saruc, Murat
name: Standop, Jens
name: Egami, Hiroshi
name: Pour, Parviz M
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Cell Proliferation; Glucose; Insulin; Pancreatic Neoplasms /prevention and control

description: Context Our previous study suggested that porcine pancreatic extract in hamsters with peripheral insulin resistance, normalizes insulin output, islet size and pancreatic DNA synthetic rate. It also inhibited the growth of human pancreatic cancer cells in nude mice. Objective To examine the potential value of the porcine pancreatic extract in controlling pancreatic carcinogenesis in this model, the present experiment was performed. Design Hamsters were fed a high fat diet and four weeks later when insulin resistance emerges, they were divided into two groups. One group received 1 g/kg BW of porcine pancreatic extract in drinking water and the other group received tap water. One week later, when insulin output normalizes in porcine pancreatic extract-treated hamsters, a single subcutaneous injection of N-nitrosobis-(2-oxopropyl) amine (BOP) at a dose of 40 mg/kg BW was given to all hamsters. The experiment was terminated at 43 weeks after the porcine pancreatic extract treatment. The number and size of pancreatic tumors, blood glucose, insulin, amylase and lipase levels, the average size of islets and the number of insulin cells/islets were determined. Results The incidence of pancreatic cancer was significantly lower in the porcine pancreatic extract group (P=0.043), as well as the plasma insulin level and the size of the islets in the porcine pancreatic extract group were significantly lower (P<0.001) than in the control group. No significantly differences were found in the glucose level between the groups. Conclusion These results show that porcine pancreatic extract has a potential to inhibit pancreatic cancer growth.
description: JOP. Journal of the Pancreas, Vol 13, N° 5 (2012): September - p. 470-547
Task-type-specific use of facets in discovering online content
Creators: name: Kessler, Kristof
Publisher: name: University of British Columbia
Year: 2013

description: As noted by Herbert Simon, the challenge presented by the rich information ecologies of our time is one of shortage of attention. Hence it is necessary for important information to stand out. This research proposes that facets used in the context of full text search, support this ‘attention getting’. Faceted search has proven to provide more effective information-seeking support to users in some situations. To date, studies have focused on specific domains typically using a specific set of facets. Consequently, little is known about the effect of faceted search on a broader range of task types. This research investigates the effect of faceted search in a task context. In this process questions about the differences in perceived usefulness and actual use, and whether systems providing facets lead to a higher user satisfaction, effectiveness, and efficiency compared to systems without this capability are answered by means of a systems review, an online questionnaire, and an experimental user study. The systems review revealed 47 potential facets used across the 12 systems perused. 14 of these facets from different levels of observed prevalence were used in the online questionnaire to determine their perceived usefulness across three types of search tasks: Doing, Known-Item, and Learning. Results of the questionnaire research show a significant difference in the perceived usefulness of the facets between Doing and Learning tasks. Six out of the 14 facets, 4 perceived as highly and 2 as less useful, were incorporated into an experimental government search system for comparison to a baseline system not providing facet capabilities. An experimental user study employing these systems found that there were some differences in the perceived usefulness and actual use of facets. Specifically, the audience facet, which received low usefulness scores in the questionnaire, was used quite frequently in the user study. Only few statistically significant differences between the baseline and experimental system were found. The most notable differences were found in Perceived Success, a measure of effectiveness, and Level of Satisfaction, a measure of satisfaction, between the first and third tasks performed in the experimental system, with the third task showing higher scores.
Reduction in Delayed Gastric Emptying Following Non-Pylorus Preserving Pancreaticoduodenectomy by Addition of a Braun Enteroenterostomy
Creators: name: Nikfarjam, Mehrdad
name: Houli, Nezor
name: Tufail, Farrukh
name: Weinberg, Laurence
name: Muralidharan, Vijayaragavan
name: Christophi, Christopher
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Gastroparesis; Pancreaticoduodenectomy; Pancreatic Fistula

description: Context Delayed gastric emptying is a major cause of morbidity following pancreaticoduodenectomy. Objective The impact of a Braun enteroenterostomy on delayed gastric emptying, used in reconstruction following classic pancreaticoduodenectomy, was assessed. Patients Forty-four consecutive patients undergoing non-pylorus preserving pancreaticoduodenectomy from 2009 to 2011 by a single surgeon were included in this study. Interventions The first 20 patients had a standard antecolic gastroenterostomy and the subsequent 24 had the addition of a Braun enteroenterostomy. Results Patient characteristics, the extent of surgery, surgical findings and tumor characteristics were similar between the two groups. The delayed gastric emptying rate in the Braun enteroenterostomy (1/24, 4.2%) was significantly lower (P=0.008) than the standard reconstruction group (7/20, 35.0%). In the standard group, 6 of 7 cases (85.7%) of delayed gastric emptying were class C in nature. After exclusion of 8 total pancreatectomy patients, the pancreatic fistula rate in the Braun enteroenterostomy group (4/19, 21.1%) was similar (0.706) to the standard reconstruction group (5/17, 29.4%) as was the median length of hospital stay (10 days vs. 15 days; P=0.291). Braun enteroenterostomy technique was the only significant independent factor associated with reduced delayed gastric emptying with an odds ratio of 0.08 (95% confidence interval: 0.01-0.73; P=0.025). Conclusion The use of Braun enteroenterostomy following non-pylorus preserving pancreaticoduodenectomy appears to result in a significant reduction in delayed gastric emptying.
description: JOP. Journal of the Pancreas, Vol 13, N° 5 (2012): September - p. 470-547
Generation of the triphasic electromyographic pattern accompanying targeted ballistic movements
Creators: name: Forgaard, Christopher James
Publisher: name: University of British Columbia
Year: 2013

description: Muscles involved in rapid, targeted movements about a single-joint often display a triphasic (agonist – antagonist – agonist) electromyographic (EMG) pattern. Early work using movement perturbations suggested that for short movements, the entire EMG pattern was prepared and initiated in advance (Wadman et al., 1979), whereas more recent TMS evidence indicates that the ANT may be programmed separately (MacKinnon & Rothwell, 2000) with execution of the bursts occurring serially (Irlbacher et al., 2006). The purpose of this thesis was to investigate the generation of triphasic EMG bursts for movements of different amplitudes. In Experiment 1, participants performed rapid elbow extension movements to 20˚ and 60˚ targets and on some trials, a startling acoustic stimulus (SAS), which is thought to trigger prepared motor commands at short latency, was delivered at the onset of AG1. For short movements, this perturbation elicited ANT and AG2 early, suggesting the agonist and antagonist bursts may have been programmed separately and were sufficiently prepared (for SAS trigger) at the time of AG1 onset. In contrast, the same manipulation did not disrupt EMG timing parameters for the long movement, where the ANT and AG2 bursts normally occurred later. The inability to trigger these bursts separate from AG1 raised the possibility that for a longer movement, ANT and AG2 were not fully prepared in advance of movement onset. In Experiment 2, generation of the ANT (and AG2) bursts underlying a longer movement was examined in more detail. We presented a SAS later in movement, relative to each participant’s expected ANT onset (70 ms before). This perturbation produced an early onset of both the ANT and AG2 bursts. Similar to recent TMS findings, our findings suggest that the triphasic pattern is executed serially. By manipulating movement amplitude, and thus specific EMG timing characteristics, we have shown the trigger signal for initiating the ANT burst occurs not in direct relation to the AG1 burst, but rather in close temporal proximity to the expected onset of ANT.
Kambrium-Vendi töörühma välipäevik 26
Creators: name: Pirrus, Enn
name: Mens, Kaisa
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1978
Subjects: Cambrian
geological descriptions

description: Field notebook with descriptions of Cambrian outcrops in Leningrad oblast (first in 1968, comments 1978)
Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater
Creators: name: Beggs, Rachel E
name: Kelly, Michael E
name: Eltayeb, Omer
name: Crotty, Paul
name: McDermott, Ray
name: Ridgway, Paul F
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Ampulla of Vater; Carcinoma, Large Cell

description: Context Large cell neuroendocrine carcinomas of the ampulla of Vater are rare and confer a very poor prognosis despite aggressive therapy. There are few case reports of large cell neuroendocrine carcinomas of the ampulla of Vater in the literature and to date no studies have been done to establish optimal management. We describe a pooled case series from published reports of neuroendocrine carcinomas of the ampulla of Vater including a case which presented to our institution. Methods A narrative review was undertaken including all published English case reports of large cell neuroendocrine carcinomas of the ampulla of Vater. Our primary outcome was to determine the overall survival. Results Twenty cases of large cell neuroendocrine carcinomas of the ampulla of Vater were identified. Seventy-six percent of patients were reported to have died of disease with a mean survival of 11.8 months. Twenty percent of the tumours were associated with an adenoma. The approximate median survivals were 15 months for those with an associated adenoma and 11 months without. Conclusions This pooled analysis demonstrates both the rarity and poor prognosis of large cell neuroendocrine carcinomas of the ampulla of Vater. Although surgical resection is the mainstay of treatment, we review common adjuvant chemotherapy regimes. Prognosis may be improved when these tumours are associated with adenomas, however, further studies are needed.
description: JOP. Journal of the Pancreas, Vol 13, N° 5 (2012): September - p. 470-547
Mioserica Zhang 1989
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Mioserica

description: Mioserica Zhang,1989
[1 species].
Typespecies Mioserica margelis Zhang, 1989, by original designation.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 145, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Kambrium-Vendi töörühma välipäevik 27
Creators: name: Pirrus, Enn
name: Mens, Kaisa
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1970
Subjects: Cambrian
geological descriptions

description: Field notebook with descriptions of Cambrian outcrops in Estonia (west of Tallinn)
The quantum group, Harper equation and the structure of Bloch eigenstates on a honeycomb lattice
Creators: name: Eliashvili, Merab
name: Japaridze, George I.
name: Tsitsishvili, George
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The tight-binding model of quantum particles on a honeycomb lattice is investigated in the presence of homogeneous magnetic field. Provided the magnetic flux per unit hexagon is rational of the elementary flux, the one-particle Hamiltonian is expressed in terms of the generators of the quantum group $U_q(sl_2)$. Employing the functional representation of the quantum group $U_q(sl_2)$ the Harper equation is rewritten as a systems of two coupled functional equations in the complex plane. For the special values of quasi-momentum the entangled system admits solutions in terms of polynomials. The system is shown to exhibit certain symmetry allowing to resolve the entanglement, and basic single equation determining the eigenvalues and eigenstates (polynomials) is obtained. Equations specifying locations of the roots of polynomials in the complex plane are found. Employing numerical analysis the roots of polynomials corresponding to different eigenstates are solved out and the diagrams exhibiting the ordered structure of one-particle eigenstates are depicted.
description: 11 pages, 4 figures
Magnetic field decay in neutron stars: from Soft Gamma Repeaters to "weak field magnetars"
Creators: name: Dall'Osso, S.
name: Granot, J.
name: Piran, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The recent discovery of the "weak field, old magnetar", the soft gamma repeater SGR 0418+5729, whose dipole magnetic field is less than 7.5 \times 10^{12} G, has raised perplexing questions: How can the neutron star produce SGR-like bursts with such a low magnetic field? What powers the observed X-ray emission when neither the rotational energy nor the magnetic dipole energy are sufficient? These observations, that suggest either a much larger energy reservoir or a much younger true age (or both), have renewed the interest in the evolutionary sequence of magnetars. We examine, here, a phenomenological model for the magnetic field decay: B_dip} \propto (B_dip)^{1+a} and compare its predictions with the observed period, P,the period derivative, \dot{P}, and the X-ray luminosity, L_X, of magnetar candidates. We find a strong evidence for a dipole field decay on a timescale of \sim 10^3 yr for the strongest (\sim 10^{15} G) field objects, with a decay index within the range 1 \leq a < 2 and more likely within 1.5\lesssim a \lesssim 1.8. The decaying field implies a younger age than what is implied by the spinown age. Surprisingly, even with the younger age, the energy released in the dipole field decay is insufficient to power the X-ray emission, suggesting the existence of a stronger internal field, B_int. Examining several models for the internal magnetic field decay we find that it must have a very large (> 10^{16} G) initial value. Our findings suggest two clear distinct evolutionary tracks -- the SGR/AXP branch and the transient branch, with a possible third branch involving high-field radio pulsars that age into low luminosity X-ray dim isolated neutron stars.
description: 47 pages, 11 figures, accepted for publication on MNRAS, in press
Synchronous Presentation of Ampullary Adenocarcinoma and Common Bile Duct Cancer: Report of a Case and Review of Literature
Creators: name: Wohlauer, Max V
name: McManus, Martine C
name: Brauer, Brian
name: Hedges, Jeremy
name: Gajdos, Csaba
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Adenocarcinoma; Adenoma; Ampulla of Vater; Cholangiopancreatography, Endoscopic Retrograde; Common Bile Duct Neoplasms; Neoplasms, Multiple Primary; Pancreaticoduodenectomy; Adult; Lymphatic Metastasis; Aged

description: Context Ampullary adenocarcinomas and bile duct cancers represent a very small minority of all gastrointestinal malignancies. Synchronous presentation of both malignancies is extremely rare. Case report We report a case of a 76-year-old male who presented with painless jaundice. His work-up showed an ampullary mass and a separate common bile duct stricture. Attempted endoscopic resection established the diagnosis of ampullary adenocarcinoma. Pathologic examination of the Whipple specimen identified a separate focus of bile duct cancer. Conclusion Synchronous presentation of an ampullary mass and separate distal bile duct stricture, especially in elderly patients, should raise concern for both lesions representing malignancies. In the absence of conclusive evidence for survival advantage in resected early stage ampullary and biliary cancers, close observation should be considered a valid alternative to adjuvant chemotherapy and radiation.
description: JOP. Journal of the Pancreas, Vol 13, N° 5 (2012): September - p. 470-547
The targum (1869:Jan.)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1869

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Moronoserica Ahrens, Lukic & Liu 2023
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Moronoserica

description: Moronoserica Ahrens, Lukic & Liu in Ahrens, et al., 2023
[14 species].
Type species Microserica lineata Moser, 1915, by original designation.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 145, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437