Additional file 1 of Understanding the age spectrum of respiratory syncytial virus associated hospitalisation and mortality burden based on statistical modelling methods: a systematic analysis
Creators: name: Cong, Bingbing
name: Dighero, Izzie
name: Zhang, Tiantian
name: Chung, Alexandria
name: Nair, Harish
name: Li, You
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Additional details on methods, characteristics of included studies, quality assessment, results of sensitivity and meta-analysis. Text S1. PRISMA 2020 Checklist. Text S2. Synthesis without meta-analysis in systematic reviewsreporting guideline. Text S3. Search Strategies. Text S4. Data extraction proforma. Text S5. Description of multilevel model with random effects. Text S6. Modelling methods. Text S7. Model characteristics. Figure S1. Geographical distribution of studies included. Figure S2. Median, IQR and ranges of reported estimates of rates of RSV-associated hospitalisation by country income level. Figure S3. Annual rates of RSV-associated ARI hospitalisation per 100,000 over time by study and age group. Figure S4. Annual rates of RSV-associated mortality per 100,000 over time by study and age group. Figure S5. Forest plots of meta-analysis of age-specific RSV-associated hospitalisation rates in high income countries by age group and case definition. Figure S6. Forest plots of meta-analysis of age-specific RSV-associated mortality rates in upper-middle-income countries by age group and case definition. Figure S7. Comparison of median estimatesand meta estimatesfor RSV-associated hospitalisation and mortality. Table S1. Risk of bias and quality assessment for included studies. Table S2. Summary of modelling studies reporting RSV-associated hospitalisation. Table S3. Summary of modelling studies reporting RSV-associated mortality. Table S4. Definitions of RSV-epidemic periods used in studies applying rate-difference methods. Table S5. Summary of the reported average annual estimates of RSV all-cause mortality rate. Table S6. Summary of the reported average annual estimates of RSV-C&amp;R hospitalisation and mortality rate. Table S7. Summary of the reported average annual estimates of RSV-ARI hospitalization rate. Table S8. Summary of the reported average annual estimates of RSV-ARI mortality rate. Table S9. Summary of the reported average annual estimates of RSV-ALRI hospitalisation and mortality rate. Table S10. Summary of the reported average annual estimates of RSV-P&amp;I hospitalisation and mortality rate. Table S11. Methods for estimating RSV-associated hospitalisation and mortality. Table S12. Modelling approaches for estimation of RSV-associated hospitalisation and mortality. Table S13. Median and range of reported estimates of ALRI, P&amp;I, C&amp;R and ARI hospitalisation associated with RSV per 100,000 by age group in high income countries. Table S14. Median and range of reported estimates of ALRI, P&amp;I, C&amp;R and ARI hospitalisation associated with RSV per 100,000 by age group in high income countries when excluding low-quality studies. Table S15. Median, IQR and range of reported estimates of all-cause, C&amp;R, ARI and P&amp;I mortality associated with RSV per 100,000 by age group globally. Table S16. Median, IQR and range of reported estimates of all-cause, C&amp;R, ARI and P&amp;I mortality associated with RSV per 100,000 by age group in high income countries. Table S17. Median, IQR and range of reported estimates of all-cause, C&amp;R, ARI and P&amp;I mortality associated with RSV per 100,000 by age group in upper-middle-income countries. Table S18. Median, IQR and range of reported estimates of all-cause, C&amp;R, ARI and P&amp;I mortality associated with RSV per 100,000 by age group in high income countries when excluding low-quality studies.