title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¼Ð¾ÑÑÐ¾ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ðµ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ñ Ð¼Ð¾Ð»Ð¾Ð´ÑÑ ÐºÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Morphological and functional changes in rat hippocampus with the lithium-pilocarpine model of temporal lobe epilepsy induced in juvenile age
Creators: name: ÐÑÐ»ÐµÐºÐ¶Ð°Ð½Ð¸Ð½Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð´ÐµÑÑÐºÐ°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð²Ð¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½
Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿
Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ñ
Ð°ÑÑÑÐ¾Ð³Ð»Ð¸Ð¾Ð·
pediatric epilepsy
temporal lobe epilepsy
pilocarpine
hippocampus
neurogenesis
astrogliosis

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description: The given work is devoted to studying morphological and functional changes in rat hippocampus with the lithium-pilocarpine model of temporal lobe epilepsy induced in juvenile age. The work was made in the I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences. The study was conducted on Wistar rats 1, 3 and 7 days in an epileptic status (latent phase) and 30 days (chronic phase of the disease). The research set the following goals: 1) To identify morphological changes in the hippocampal fields CA3, CA1, dentate gyrus and hilus in the latent and chronic phases of temporal lobe epilepsy; 2) To identify changes in the glial morphometric parameters detected immunohistochemically in the rat hippocampus in the latent and chronic phases of temporal lobe epilepsy. 3) To identify electrophysiological features in the CA1 hippocampal field in the latent and chronic phases of temporal lobe epilepsy by field potentials recording. As a result, we counted neurons and analyzed astrocytic distribution in various hippocampal fields, and assessed the excitatory synaptic transmission in the CA1 hippocampal field. According our results, pilocarpine â induced epileptic status is accompanied by significant morphological disturbances such as a neural number reduction and an increasing of GFAP â positive cells distribution, and functional disturbances, such as synaptic transmission impairment.