cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Toward Scalable Many-Body Calculations for Nuclear Open Quantum Systems using the Gamow Shell Model
Creators: name: Michel, Nicolas
name: Aktulga, Hasan Metin
name: Jaganathen, Yannen
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Drip-line nuclei have very different properties from those of the valley of stability, as they are weakly bound and resonant. Therefore, the models devised for stable nuclei can no longer be applied therein. Hence, a new theoretical tool, the Gamow Shell Model (GSM), has been developed to study the many-body states occurring at the limits of the nuclear chart. GSM is a configuration interaction model based on the use of the so-called Berggren basis, which contains bound, resonant and scattering states, so that inter-nucleon correlations are fully taken into account and the asymptotes of extended many-body wave functions are precisely handled. However, large complex symmetric matrices must be diagonalized in this framework, therefore the use of very powerful parallel machines is needed therein. In order to fully take advantage of their power, a 2D partitioning scheme using hybrid MPI/OpenMP parallelization has been developed in our GSM code. The specificities of the 2D partitioning scheme in the GSM framework will be described and illustrated with numerical examples. It will then be shown that the introduction of this scheme in the GSM code greatly enhances its capabilities.
description: 23 pages; 5 figures; accepted in Computer Physics Communications, in press
A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature
Creators: name: Zhao, Zhongwei
name: Weickmann, Sabine
name: Jung, Monika
name: Lein, Michael
name: Kilic, Ergin
name: Stephan, Carsten
name: Erbersdobler, Andreas
name: Fendler, Annika
name: Jung, Klaus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: microRNAs
subject: prostate cancer
subject: radical prostatectomy
subject: tissue-based biomarkers
subject: prognostic biomarkers
subject: biochemical recurrence
subject: prediction accuracy
subject: predictive models
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Within five to ten years after radical prostatectomy (RP), approximately 15-34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating probable cancer recurrence. Models using clinicopathological variables for predicting this risk for patients lack accuracy. There is hope that new molecular biomarkers, like microRNAs (miRNAs), could be potential candidates to improve risk prediction. Therefore, we evaluated the BCR prognostic capability of 20 miRNAs, which were selected by a systematic literature review. MiRNA expressions were measured in formalin-fixed, paraffin-embedded (FFPE) tissue RP samples of 206 PCa patients by RT-qPCR. Univariate and multivariate Cox regression analyses were performed, to assess the independent prognostic potential of miRNAs. Internal validation was performed, using bootstrapping and the split-sample method. Five miRNAs (miR-30c-5p/31-5p/141-3p/148a-3p/miR-221-3p) were finally validated as independent prognostic biomarkers. Their prognostic ability and accuracy were evaluated using C-statistics of the obtained prognostic indices in the Cox regression, time-dependent receiver-operating characteristics, and decision curve analyses. Models of miRNAs, combined with relevant clinicopathological factors, were built. The five-miRNA-panel outperformed clinically established BCR scoring systems, while their combination significantly improved predictive power, based on clinicopathological factors alone. We conclude that this miRNA-based-predictor panel will be worth to be including in future studies.
The Effects of Thickness Changes in Different Composites on Translucency, Opalescence, and Masking Efficacy
Creators: name: Değirmenci, Beyza Ünalan
name: Değirmenci, Alperen
Publisher: name: figshare
Year: 2020
Subjects: subject: 110501 Dental Materials and Equipment
subject: FOS: Clinical medicine

description: Objective: The aim of this study is to evaluate the effects of thickness increase in nanohybrid and microhybrid composites on translucency, opalescence and masking efficacy. Material and methods: For this study, a total of 72 composite discs with thicknesses of 1, 1.5 and 2 mm were prepared from nanohybrid and microhybrid composites. Disk measurements were made with the aid of a spectrophotometer and translucency parameter (TP), opalescence (OP-BW) and masking efficacy (ME) were calculated. Results: The decrease in the values of TP and OP-BW and increase in the values of ME were observed with thickness increase in both microhybrid and nanohybrid composites. Moreover, while statistically significant positive correlation was detected between TP and OP-BW, it was also detected that ME and TP and ME and OP-BW were statistically significant between each other but negative correlation was detected. Discussion: The thickness of composite materials directly affects the aesthetic properties of restorative materials.
Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
Creators: name: Beier, Laura-Sophie
name: Rossa, Jan
name: Woodhouse, Stephen
name: Bergmann, Sophia
name: Kramer, Holger B.
name: Protze, Jonas
name: Eichner, Miriam
name: Piontek, Anna
name: Vidal-Y-Sy, Sabine
name: Brandner, Johanna M.
name: Krause, Gerd
name: Zitzmann, Nicole
name: Piontek, Jörg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Clostridiumperfringens enterotoxin
subject: claudin-1
subject: Hepatitis C Virus
subject: viral entry
subject: epidermal barrier
subject: reconstructed human epidermis
subject: claudin targeting
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1). Cldn1 is a pharmacological target since it is (i) an essential co-receptor for hepatitis C virus (HCV) infections and (ii) a key element of the epidermal barrier limiting drug delivery. In this study, we investigated the potential of a Cldn1-binding cCPE mutant (i) to inhibit HCV entry into hepatocytes and (ii) to open the epidermal barrier. Inhibition of HCV infection by blocking of Cldn1 with cCPE variants was analyzed in the Huh7.5 hepatoma cell line. A model of reconstructed human epidermis was used to investigate modulation of the epidermal barrier by cCPE variants. In contrast to cCPEwt, the Cldn1-binding cCPE-S305P/S307R/S313H inhibited infection of Huh7.5 cells with HCV in a dose-dependent manner. In addition, TJ modulation by cCPE variant-mediated targeting of Cldn1 and Cldn4 opened the epidermal barrier in reconstructed human epidermis. cCPE variants are potent claudin modulators. They can be applied for mechanistic in vitro studies and might also be used as biologics for therapeutic claudin targeting including HCV treatment (host-targeting antivirals) and improvement of drug delivery.
The Majorana Neutrinoless Double-Beta Decay Experiment
Creators: name: Aalseth
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The proposed Majorana double-beta decay experiment is based on an array of segmented intrinsic Ge detectors with a total mass of 500 kg of Ge isotopically enriched to 86% in 76Ge. A discussion is given of background reduction by: material selection, detector segmentation, pulse shape analysis, and electro-formation of copper parts and granularity. Predictions of the experimental sensitivity are given. For an experimental running time of 10 years over the construction and operation of Majorana, a half-life sensitivity of ~4x10^27 y (neutrinoless) is predicted. This corresponds to an effective Majorana mass of the electron neutrino of ~0.03-0.04 eV, according to recent QRPA and RQRPA matrix element calculations.
description: 10 pages, 7 figures
Pseudosinella sollaudi Denis 1924
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella sollaudi

description: Pseudosinella sollaudi Denis, 1924 *
Pseudosinella sollaudi Denis, 1924b: 198.
DISTRIBUTION. — Doubs. Grottedes Faux-Monnayeurs, gouffregrottedela Beaumedu Montà Reugney (Denis 1924b, c). — Grotte de Chauveroche (Gisin 1960b). — Grottesde Gonsans à Gonsans près de Roulans, des Cavottes à Montrond près de Quingey, des Faux-Monnayeurs à Mouthier-Hautepierre, du Baume du Mont à Reugney près d’Amancey, des Orcières à Montivernace près de Baume-les-Dames, dela Source Bergeretà Arcierprèsde Besançonnord et de Grange Mathieu à Chenecey (Gisin & Gama 1970a; Gama 1976).
Drôme. Grottesdes Déramats à Saint-Martin-en-Vercors, de Barmechenelleà Saint-Julien-en-Vercors etde Ferrières à La Chapelleen-Vercors (Ginet 1961).
Isère. Grotte de Pré-l’Étang à Presles, glacière de Corrençon (Ginet 1961).
TAXONOMIE. — Denis 1924c (redescription); Gisin & Gama 1970a (redescription); Gama 1976 (redescription).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 392, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Perpendicularly Magnetized Ni / Pt (001) Epitaxial Superlattice
Creators: name: Seki, T.
name: Tsujikawa, M.
name: Ito, K.
name: Uchida, K.
name: Kurebayashi, H.
name: Shirai, M.
name: Takanashi, K.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A perpendicularly magnetized ferromagnetic layer is an important building block for recent/future highdensity spintronic memory applications. This paper reports on the fabrication of perpendicularly magnetized Ni / Pt superlattices and the characterization of their structures and magnetic properties. The optimization of film growth conditions allowed us to grow epitaxial Ni / Pt (001) superlattices on SrTiO$_{3}$ (001) single crystal substrates. We investigated their structural parameters and magnetic properties as a function of the Ni layer thickness, and obtained a high uniaxial magnetic anisotropy energy of 1.9 x 10$^{6}$ erg/cm$^{3}$ for a [Ni (4.0 nm) / Pt (1.0 nm)] superlattice. In order to elucidate the detailed mechanism on perpendicular magnetic anisotropy for the Ni / Pt (001) superlattices, the experimental results were compared with the first-principles calculations. It has been found that the strain effect is a prime source of the emergence of perpendicular magnetic anisotropy.
description: 33 pages, 12 figures
Intestinal Barrier Function in Gluten-Related Disorders
Creators: name: Cardoso-Silva, Danielle
name: Delbue, Deborah
name: Itzlinger, Alice
name: Moerkens, Renée
name: Withoff, Sebo
name: Branchi, Federica
name: Schumann, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: epithelial barrier
subject: permeability
subject: celiac disease
subject: non-celiac gluten sensitivity
subject: non-celiac wheat sensitivity
subject: wheat allergy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the contact of the gastrointestinal mucosa with components of wheat and other cereals as a causative factor, these clinical entities have distinct pathophysiological pathways. In celiac disease, a T-cell mediate immune reaction triggered by gluten ingestion is central in the pathogenesis of the enteropathy, while wheat allergy develops as a rapid immunoglobulin E- or non-immunoglobulin E-mediated immune response. In non-celiac wheat sensitivity, classical adaptive immune responses are not involved. Instead, recent research has revealed that an innate immune response to a yet-to-be-defined antigen, as well as the gut microbiota, are pivotal in the development in this disorder. Although impairment of the epithelial barrier has been described in all three clinical conditions, its role as a potential pathogenetic co-factor, specifically in celiac disease and non-celiac wheat sensitivity, is still a matter of investigation. This article gives a short overview of the mucosal barrier of the small intestine, summarizes the aspects of barrier dysfunction observed in all three gluten-related disorders and reviews literature data in favor of a primary involvement of the epithelial barrier in the development of celiac disease and non-celiac wheat sensitivity.
Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling-Supplemental materials
Creators: name: Zhang, Xizi
name: Shu, Xiaoyu
name: Yang, Jun
name: Cheng, Qingfeng
name: Du, Zhipeng
name: Song, Ying
name: Yang, Yi
name: Hu, Jinbo
name: Long, Jian
name: Wu, Feifei
name: Li, Qifu
name: Yang, Shumin
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320208
subject: Endocrinology

description: The supplemental data of the manuscript: Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling
Molecular Counterparts of Ultracompact HII Regions with Extended Envelopes
Creators: name: Kim, Kee-Tae
name: Koo, Bon-Chul
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We carried out 13CO J=1-0, CS, and C34S J=2-1 and J=3-2 line observations of molecular clouds associated with 16 ultracompact (UC) HII regions with extended envelopes. The molecular clouds are the ones that give birth to rich stellar clusters and/or very massive (O7-O4) stars. Our data show that the clouds are very clumpy and of irregular morphology. They usually have much larger masses, velocity dispersions, and fractions of dense gas than molecular clouds that form early B or late O stars. This is compatible with earlier findings that more massive stars form in more massive cores. 13CO cores are in general associated with compact HII regions regardless of the presence of UC HII regions therein. In contrast, CS cores are preferentially associated with compact HII regions that contain UC HII regions. As with the fact that the compact HII regions containing UC HII regions are more compact than those not associated with UC HII regions, these indicate that the former may be in an earlier evolutionary phase than the latter. The diffuse extended envelopes of HII regions often develop in the direction of decreasing molecular gas density. Based on detailed comparison of molecular line data with radio continuum and recombination line data, the extended ionized envelopes are likely the results of champagne flows in at least 10 sources in our sample. Together these results appear to support a published suggestion that the extended emission around UC HII regions can be naturally understood by combining the champagne flow model with the hierarchical structure of molecular clouds. We discuss the implication of our results for the blister model of HII regions.
description: 36 pages, including 30 figures, accepted for publication in ApJ
Using Semantic Web Technologies to Query and Manage Information within Federated Cyber-Infrastructures
Creators: name: Willner, Alexander
name: Giatili, Mary
name: Grosso, Paola
name: Papagianni, Chrysa
name: Morsey, Mohamed
name: Baldin, Ilya
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 004 Datenverarbeitung; Informatik
subject: Semantic Web
subject: federated infrastructures
subject: RDF
subject: OWL
subject: SPARQL

description: A standardized descriptive ontology supports efficient querying and manipulation of data from heterogeneous sources across boundaries of distributed infrastructures, particularly in federated environments. In this article, we present the Open-Multinet (OMN) set of ontologies, which were designed specifically for this purpose as well as to support management of life-cycles of infrastructure resources. We present their initial application in Future Internet testbeds, their use for representing and requesting available resources, and our experimental performance evaluation of the ontologies in terms of querying and translation times. Our results highlight the value and applicability of Semantic Web technologies in managing resources of federated cyber-infrastructures.
Human endogenous retrovirus K (HERV-K) env in neuronal extracellular vesicles: a new biomarker of motor neuron disease
Creators: name: Li, Yuan
name: Chen, Yong
name: Zhang, Nan
name: Fan, Dongsheng
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Cancer
subject: Virology

description: Objective: Human endogenous retroviruses (HERVs) have been gradually confirmed to be involved in the onset and progression of motor neuron disease(MND). However, noninvasive detection of HERVs in the central nervous system is lacking. The aim of this study is to verify the relationship between the level of HERV-K env in neuronal extracellular vesicles in plasma and the onset and severity of MND. Methods: We extracted neuronal extracellular vesicles from plasma of 39 MND patients and 30 age- and sex-matched controls, and detected HERV-K env in extracellular vesicles by an enzyme-linked immunosorbent assay (ELISA). Results: Levels of HERV-K env in neuronal extracellular vesicles positively associated with range of lower motor neurons (LMNs) involved (1.66 ± 0.37 vs. 1.35 ± 0.34, p = 0.041), ALS phenotype (1.52 ± 0.31 vs. 1.24 ± 0.37, p = 0.013) and course of disease (1.83 ± 0.35 vs. 1.42 ± 0.22, p = 0.003), and increased in advanced-phase MND (definite and probable according to revised EI Escorial criteria) compared with early-phase MND (possible and lab-supported probable), albeit without very profound significance (1.52 ± 0.34 vs. 1.29 ± 0.36, p = 0.048). Conclusions: In conclusion, levels of HERV-K env in neuronal extracellular vesicles extracted from plasma can be used as a noninvasive biomarker of severity of MND.
Emerging concepts on the use of ketamine for chronic pain
Creators: name: Yunpeng Yang
name: Maher, Dermot P.
name: Cohen, Steven P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Introduction: The use of ketamine infusions for chronic pain has surged, with utilization exceeding the proliferation of knowledge. A proposed mechanism for the long-term benefit in chronic pain is that ketamine may alter the affective-motivational component of pain. Areas covered: In this review, we discuss the classification and various dimensions of pain, and explore the effects of ketamine on different pain categories and components. The relationship between ketamine’s action at the NMDA receptor, the development of chronic pain, and the its possible role in preventing the persistence of pain are examined. We also summarize animal models evaluating the antinociceptive effects of ketamine and risk mitigation strategies of ketamine-associated side effects. Expert opinion: Although ketamine exerts most of its analgesic effects via the NMDA receptor, recent evidence suggests that other receptors such as AMPA, and active metabolites such as nor-ketamine, may also play a role in pain relief and alleviation of depression. Data from clinical studies performed in patients with chronic pain and depression, and the observation that ketamine’s analgesic benefits outlast its effects on quantitative sensory testing, suggest that the enduring effects on chronic pain may be predominantly due ketamine’s ability to modulate the affective-motivational dimension of pain.
Logarithmic Potential with Super-Super-Exponential Kink Profiles and Tails
Creators: name: Khare, Avinash
name: Saxena, Avadh
Publisher: name: arXiv
Year: 2019
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We consider a novel one dimensional model of a logarithmic potential which has super-super-exponential kink profiles as well as kink tails. We provide analytic kink solutions of the model -- it has 3 kinks, 3 mirror kinks and the corresponding antikinks. While some of the kink tails are super-super-exponential, some others are super-exponential whereas the remaining ones are exponential. The linear stability analysis reveals that there is a gap between the zero mode and the onset of continuum. Finally, we compare this potential and its kink solutions with those of very high order field theories harboring seven degenerate minima and their attendant kink solutions, specifically $ϕ^{14}$, $ϕ^{16}$ and $ϕ^{18}$.
description: 23 pages, 14 figures
A new pansharpening method based on the sparse representation of classified injected details over a featured dictionary
Creators: name: Fei, Rongrong
name: Zhang, Xuande
name: Li, Wan
name: Xiong, Jing
name: Du, Fang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Space Science
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: In this paper, the characteristics of low-resolution multispectral image (LRMS) and panchromatic image (PAN) fusion methods are investigated. Recently, the sparse representation (SR) based methods and the injected details (ID) based methods have been combined as the pansharpening method based on SR of ID. This novel method can gain better results than the former ones, but it also faces two disadvantages, i.e., the choice of using the raw patches as dictionary and using the SR to all parts of the aiming image are not so optimal, which will cause inaccurate representation and sharper than it should be in the smooth area. Thus, we propose a new pansharpening method based on SR of classified ID over featured dictionary to learn dictionary from the featured details and fuse different patches diversely to overcome the drawbacks mentioned above and enhance the quality of aiming image. The experimental results using QuickBird and WorldView2 show that the proposed method can achieve remarkable spectral and spatial quality.
Atmosphere-Corrected Phase-Referencing
Creators: name: Brunthaler, A.
name: Reid, M. J.
name: Falcke, H.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: One major problem of phase-referencing VLBI observations are phase errors due to the unknown tropospheric zenith delay at each antenna. These errors degrade the quality of the phase-referenced image and limit the achievable astrometric accuracy. We will present and compare two independent methods to estimate the zenith delay offset at each antenna. The zenith delay offsets can then be used to correct the data. These corrections improve the quality of the phase-referenced image and an astrometric accuracy of 10 $μ$as can be achieved. With this accuracy, measurements of proper motions in the Local Group become feasible.
description: 5 pages, 1 figure, To be published in "Future Directions in High Resolution Astronomy" (A Celebration of the 10th Anniversary of the VLBA), A version with a higher resolution figure can be found at http://www.mpifr-bonn.mpg.de/staff/abrunthaler/brunthaler_paper.ps
Blood Pressure Non-Dipping and Obstructive Sleep Apnea Syndrome: A Meta-Analysis
Creators: name: Cuspidi, Cesare
name: Tadic, Marijana
name: Sala, Carla
name: Gherbesi, Elisa
name: Grassi, Guido
name: Mancia, Giuseppe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: obstructive sleep apnea
subject: non-dipping pattern
subject: meta-analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: AIM: We examined the reduced blood pressure (BP) nocturnal fall in patients with obstructive sleep apnea (OSA) by a meta-analysis including studies that provided data on prevalence rates of non-dipping (ND) pattern during 24-h ambulatory blood pressure monitoring (ABPM). DESIGN: The PubMed, OVID-MEDLINE, and Cochrane CENTRAL literature databases were searched for appropriate articles without temporal restriction up to April 2019 through focused and sensitive search methods. Studies were identified by crossing the search terms as follows: "obstructive sleep apnea", "sleep quality", "non dipping", "reduced nocturnal BP fall", "circadian BP variation", "night-time BP", and "ambulatory blood pressure monitoring". RESULTS: Meta-analysis included 1562 patients with OSA from different clinical settings and 957 non-OSA controls from 14 studies. ND pattern prevalence in patients with OSA widely varied among studies (36.0-90.0%). This was also the case for non-OSA controls (33.0% to 69.0%). Overall, the ND pattern, assessed as an event rate in the pooled OSA population, was 59.1% (confidence interval (CI): 52.0-65.0%). Meta-analysis of the seven studies comparing the prevalence of ND pattern in participants with OSA and controls showed that OSA entails a significantly increased risk of ND (Odds ratio (OR) = 1.47, CI: 1.07-1.89, p < 0.01). After the exclusion of patients with mild OSA, OR increased to 1.67 (CI: 1.21-2.28, p < 0.001). CONCLUSIONS: The present meta-analysis, extending previous information on the relationship between OSA and impaired BP dipping, based on single studies, suggests that this condition increases by approximately 1.5 times the likelihood of ND, which is a pattern associated with a greater cardiovascular risk than normal BP dipping.
Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies
Creators: name: Loosen, Sven H.
name: Schulze-Hagen, Maximilian
name: Bruners, Philipp
name: Tacke, Frank
name: Trautwein, Christian
name: Kuhl, Christiane
name: Luedde, Tom
name: Roderburg, Christoph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: HCC
subject: TACE
subject: cancer
subject: muscle weight
subject: sarcopenia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and Aims: While transarterial chemoembolization (TACE) represents a standard of therapy for intermediate-stage hepatocellular carcinoma (HCC) and is also routinely performed in patients with liver metastases, it is still debated which patients represent the ideal candidates for TACE therapy in terms of overall survival. Sarcopenia, the degenerative loss of skeletal muscle mass and strength, has been associated with an adverse outcome for various malignancies, but its role in the context of TACE has largely remained unknown. Here, we evaluated the role of sarcopenia on the outcome of patients undergoing TACE for primary and secondary liver cancer. Methods: The patients’ psoas muscle size was measured on axial computed tomography (CT) scans and normalized for the patients’ height squared. This value was referred to as the psoas muscle index (PMI). The PMI was correlated with clinical and laboratory markers. Results: While pre-interventional sarcopenia had no impact on the direct tumor response to TACE, sarcopenic patients with a pre-interventional PMI below our ideal cut-o value of 13.39 mm/m2 had a significantly impaired long-term outcome with a median overall survival of 491 days compared to 1291 days for patients with a high PMI. This finding was confirmed by uni- and multivariate Cox-regression analyses. Moreover, a progressive rapid decline in muscle mass after TACE was a predictor for an unfavorable prognosis. Conclusion: Our data suggest that sarcopenia represents a previously unrecognized prognostic factor for patients undergoing TACE therapy which might yield important information on the patients’ post-interventional outcome and should therefore be implemented into clinical stratification algorithms.
Pseudosinella stompi Gisin & Gama 1970
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella stompi

description: Pseudosinella stompi Gisin & Gama, 1970
Pseudosinella stompi Gisin & Gama, 1970a: 177.
DISTRIBUTION. — Aveyron. Grottedela Poujadeà Millau (Gisin & Gama 1970a; Gama 1976).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 392, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Cheumatopsyche galahittigama
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche galahittigama

description: Cheumatopsyche galahittigama (Schmid, 1958)
 Hydropsychodes galahittigama Schmid, 1958: 7.
 Cheumatopsyche galahittigama (Schmid, 1958); Kimmins 1963: 130.
 Type locality: Sri Lanka.
 New Record: PAKISTAN: Khwazakhela, 25.v.1992, light [Csorba & Hreblay] — 1 male (OPC, alcohol).
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 136
The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells
Creators: name: Ma, Ke
name: Wang, Wei
name: Gao, Chunyan
name: He, Jine
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Circular RNAs (circRNAs) have been implicated in the molecular etiology of pediatric pneumonia. Here, we investigated the precise action of circRNA tropomodulin 3 (circTMOD3, hsa_circ_0035292) in cell injury and inflammation induced by lipopolysaccharide (LPS). Methods: Cell viability was gauged by Cell Counting Kit-8 (CCK-8) assay. Cell apoptosis and cycle distribution were assessed by flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to measure interleukin-6 (IL-6), IL-1β and tumor necrosis factor alpha (TNF-α) production. The levels of circTMOD3, microRNA (miR)-146b-3p, and C–X–C motif chemokine receptor 1 (CXCR1) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Ribonuclease (RNase) R, Actinomycin D and subcellular localization assays were done to characterize circTMOD3. The direct relationship between miR-146b-3p and circTMOD3 or CXCR1 was confirmed by dual-luciferase reporter assays. Results: Our data showed that LPS induced the expression of circTMOD3 in WI-38 cells. CircTMOD3 was resistant to RNase R and was mainly present in the cytoplasm. Silencing endogenous circTMOD3 alleviated WI-38 cell injury and inflammation triggered by LPS. Mechanistically, circTMOD3 directly targeted miR-146b-3p, and CXCR1 was a direct and functional target of miR-146b-3p. CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation. Furthermore, circTMOD3 functioned as a competing endogenous RNA (ceRNA) for miR-146b-3p to induce CXCR1 expression. Conclusion: Our findings demonstrated the regulation of circTMOD3 in LPS-induced cell injury and inflammation at least partially via miR-146b-3p-independent modulation of CXCR1.
Cheumatopsyche kirimaduwa
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche kirimaduwa

description: Cheumatopsyche kirimaduwa (Schmid, 1958)
 Hydropsychodes kirimaduwa Schmid, 1958: 4.
 Cheumatopsyche kirimaduwa (Schmid, 1958); Kimmins 1963: 130.
 Type locality: Sri Lanka.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 136
The Demonstration Model of the ATHENA X-IFU Cryogenic AntiCoincidence Detector
Creators: name: D'Andrea, Matteo
name: Macculi, Claudio
name: Torrioli, Guido
name: Argan, Andrea
name: Brienza, Daniele
name: Lotti, Simone
name: Minervini, Gabriele
name: Piro, Luigi
name: Biasotti, Michele
name: Barusso, Lorenzo Ferrari
name: Gatti, Flavio
name: Rigano, Manuela
name: Volpe, Angela
name: Battistelli, Elia Stefano
Publisher: name: arXiv
Year: 2019
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The Cryogenic AntiCoincidence Detector (CryoAC) of ATHENA X-IFU is designed to reduce the particle background of the instrument and to enable the mission science goals. It is a 4 pixel silicon microcalorimeter sensed by an Ir/Au TES network. We have developed the CryoAC Demonstration Model, a prototype aimed to probe the critical technologies of the detector, i.e. the suspended absorber with an active area of 1 cm2; the low energy threshold of 20 keV; and the operation connected to a 50 mK thermal bath with a power dissipation less than 40 nW. Here we report the test performed on the first CryoAC DM sample (namely the AC-S10 prototype), showing that it is fully compliant with its requirements.
description: Accepted for publication in the Journal of Low Temperature Physics for LTD-18 special issue
Nucleation of Al3Zr and Al3Sc in aluminum alloys: from kinetic Monte Carlo simulations to classical theory
Creators: name: Clouet, Emmanuel
name: Nastar, Maylise
name: Sigli, Christophe
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Zr and Sc precipitate in aluminum alloys to form the compounds Al3Zr and Al3Sc which for low supersaturations of the solid solution have the L12 structure. The aim of the present study is to model at an atomic scale this kinetics of precipitation and to build a mesoscopic model based on classical nucleation theory so as to extend the field of supersaturations and annealing times that can be simulated. We use some ab-initio calculations and experimental data to fit an Ising model describing thermodynamics of the Al-Zr and Al-Sc systems. Kinetic behavior is described by means of an atom-vacancy exchange mechanism. This allows us to simulate with a kinetic Monte Carlo algorithm kinetics of precipitation of Al3Zr and Al3Sc. These kinetics are then used to test the classical nucleation theory. In this purpose, we deduce from our atomic model an isotropic interface free energy which is consistent with the one deduced from experimental kinetics and a nucleation free energy. We test di erent mean-field approximations (Bragg-Williams approximation as well as Cluster Variation Method) for these parameters. The classical nucleation theory is coherent with the kinetic Monte Carlo simulations only when CVM is used: it manages to reproduce the cluster size distribution in the metastable solid solution and its evolution as well as the steady-state nucleation rate. We also find that the capillary approximation used in the classical nucleation theory works surprisingly well when compared to a direct calculation of the free energy of formation for small L12 clusters.
description: submitted to Physical Review B (2004)
RXTE observations of X-ray transients IGRJ17091-3624 and IGRJ18539+072
Creators: name: Lutovinov, A. A.
name: Revnivtsev, M. G.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present results of analysis of observations of two transient sources IGR J17091-3624 and IGR J18539+0727 in April 2003 with RXTE observatory. Obtained energy spectra of sources, and also power spectra of their flux variations give us a possibility to classify them as X-ray binary systems in low/hard spectral state. Parameters of power spectrum of IGR J18539+0727 indicates that this source is a black hole candidate.
description: 5 pages, accepted for publication in the Astronomy Letters
Additional file 1 of Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor
Creators: name: Zhang, Dengyang
name: He, Chunxiao
name: Guo, Yao
name: Li, Jianfeng
name: Li, Bo
name: Zhao, Yuming
name: Yu, Liuting
name: Chang, Zhiguang
name: Pei, Hanzhong
name: Yang, Ming
name: Li, Na
name: Zhang, Qi
name: He, Yulong
name: Pan, Yihang
name: Zhao, Zhizhuang Joe
name: Zhang, Changhua
name: Chen, Yun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 1: Supplemental Figure S1. The effect of SCF-Fc-DM1 on GIST 430 cells in mice. A. Conjugation of SCF-Fc and DM1. Lane1: pre-stained protein marker; Lane2: rhSCF-Fc protein; Lane3: rhSCF-Fc conjugated with SMCC (SCF-Fc-SMCC); Lane4: SCF-Fc-SMCC conjugated with DM1 (SCF-Fc-DM1). B. Effect of SCF-Fc-DM1 on GIST 430 cells in vitro by FACS analysis. C. Tumor volumes of mice treated with SCF-Fc-DM1 or FL-Fc-DM1 as the control. SCF-Fc-DM1 (6.0 mg/kg) and control (FL-Fc-DM1, 6.0 mg/kg) were administrated once on day zero. D. Tumors dissected from mice.
Decision Explanation and Feature Importance for Invertible Networks
Creators: name: Zhuang, Juntang
name: Dvornek, Nicha C.
name: Li, Xiaoxiao
name: Yang, Junlin
name: Duncan, James S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Deep neural networks are vulnerable to adversarial attacks and hard to interpret because of their black-box nature. The recently proposed invertible network is able to accurately reconstruct the inputs to a layer from its outputs, thus has the potential to unravel the black-box model. An invertible network classifier can be viewed as a two-stage model: (1) invertible transformation from input space to the feature space; (2) a linear classifier in the feature space. We can determine the decision boundary of a linear classifier in the feature space; since the transform is invertible, we can invert the decision boundary from the feature space to the input space. Furthermore, we propose to determine the projection of a data point onto the decision boundary, and define explanation as the difference between data and its projection. Finally, we propose to locally approximate a neural network with its first-order Taylor expansion, and define feature importance using a local linear model. We provide the implementation of our method: \url{https://github.com/juntang-zhuang/explain_invertible}.
description: Correct notations
Cheumatopsyche surgens Li & Tian 1990
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche surgens

description: Cheumatopsyche surgens Li & Tian, 1990
 Cheumatopsyche surgens Li & Tian, 1990: 15.
 Type locality: China (Hunan).
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 143
Pseudosinella subdobati Gisin & Gama 1970
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella subdobati

description: Pseudosinella subdobati Gisin & Gama, 1970
Pseudosinella subdobati Gisin & Gama, 1970a: 167.
DISTRIBUTION. — Haute-Saône. Grottesdela Baumeà Chaux-les- Ports et de Montcey à Montcey, les deux près de Vesoul (Gisin & Gama 1970a).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 392, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Non-asymptotically flat, non-AdS dilaton black holes
Creators: name: Clement, Gerard
name: Leygnac, Cedric
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that previously known non-asymptotically flat static black hole solutions of Einstein-Maxwell-dilaton theory may be obtained as near-horizon limits of asymptotically flat black holes. Specializing to the case of the dilaton coupling constant $α^2 = 3$, we generate from the non-asymptotically flat magnetostatic or electrostatic black holes two classes of rotating dyonic black hole solutions. The rotating dyonic black holes of the ``magnetic'' class are dimensional reductions of the five-dimensional Myers-Perry black holes relative to one of the azimuthal angles, while those of the ``electric'' class are twisted dimensional reductions of rotating dyonic Rasheed black strings. We compute the quasi-local mass and angular momentum of our rotating dyonic black holes, and show that they satisfy the first law of black hole thermodynamics, as well as a generalized Smarr formula. We also discuss the construction of non-asymptotically flat multi-extreme black hole configurations.
description: Minor corrections. 2 references added. To appear in Physical Review D
'Managing scarcity'- a qualitative study on volunteer-based healthcare for chronically ill, uninsured migrants in Berlin, Germany
Creators: name: Linke, Charlotte
name: Heintze, Christoph
name: Holzinger, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: chronic disease
subject: qualitative research
subject: undocumented migrants
subject: uninsured patients
subject: volunteer-based healthcare
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: OBJECTIVES: In Germany, healthcare for people lacking legal residency status and European Union citizens without health insurance is often provided by non-governmental organisations. Scientific studies assessing the situation of the patients with chronic diseases in this context are scarce. We aimed to characterise medical care for chronically ill migrants without health insurance and outline its possibilities and limitations from the treating physicians' perspective. DESIGN: Qualitative semi-structured interviews; qualitative content analysis. SETTING: Organisations and facilities providing healthcare for uninsured migrants: free clinics, medical practices and public health services. PARTICIPANTS: 14 physicians working regularly in healthcare for uninsured migrants. RESULTS: Delayed contact to the healthcare system was frequently addressed in the interviews. Care was described as constrained by a scarcity of resources that often impedes adequate treatment for many conditions, most pronounced in the case of oncological diseases or chronic viral infections (HIV, hepatitis). For other chronic conditions such as cardiovascular diseases or diabetes, some diagnostics and basic medications were described as partially available, while management of complications or rehabilitative measures are frequently unfeasible. For the patients with mental health problems, attainability of psychotherapeutic treatment is reported as severely limited. Care is predominantly described as fragmented with limitations to information flow and continuity. Which level of care a patient receives appears to depend markedly on the respective non-governmental organisation and the individual commitment, subjective decisions and personal connections of the treating physician. CONCLUSIONS: Restrictions in medical care for uninsured migrants have even more impact on chronically ill patients. Volunteer-based care often constitutes an inadequate compensation for regular access to the healthcare system, as it is strongly influenced by the limitation of its resources and its arbitrariness.
Unmet Need for Social and Emotional Support and Lack of Recalled Screening Is Associated with Depression in the Long-Term Course After Stroke
Creators: name: Padberg, Inken
name: Hotter, Benjamin
name: Liebenau, Andrea
name: Knispel, Petra
name: Lehnerer, Sophie
name: Heel, Sabine
name: Wellwood, Ian
name: Meisel, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: depression
subject: health-care quality
subject: risk management
subject: social-care
subject: stroke
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Details on adequate care and prevalence of depression in long-term stroke aftercare are limited. We aimed to determine long-term depression rates after stroke and to test for an association between depression and inadequate screening, socio-economic complications and lack of sub-optimal care. Patients and methods: In this cross-sectional study, 57 patients were re-invited into the clinic 2-3 years after stroke. Patients were interviewed about recalled screening concerning depression and unmet needs. Depression, the patient's social situation, and confounders were assessed by standardized scores. Results: In our study, 20% (n = 11) of patients were classified as depressed by the HDRS-17 score result. However, only 36% of all patients recalled to have been previously screened for depression and only 43% of those patients also recalled out-patient screening. Patients classified as depressed reported significantly lower recalled screening rates (9% vs 43%; p = 0.036) and higher rates of self-reported unmet need with emotional problems (72% vs 18%; p < 0.001). Depression in our study was further associated with a worse socio-economic situation, fewer social contacts, unmet needs with regard to emotional problems and higher rates of recommendations to apply for additional social support. Conclusion: Our data suggest that systematic out-patient screening for depression is lacking in stroke aftercare. Furthermore, the high rate of unmet emotional needs, the poor socio-economic situation and the higher rates of recommendations for social counselling and application for benefits suggest an undersupply of care in the out-patient setting that is more prominent in patients with depression and warrants further studies to investigate the underlying causes.