cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role
Creators: name: Mercurio, D.
name: Oggioni, M.
name: Fumagalli, S.
name: Lynch, N. J.
name: Roscher, S.
name: Minuta, D.
name: Perego, C.
name: Ippati, S.
name: Wallis, R.
name: Schwaeble, W. J.
name: De Simoni, M.-G.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research
Traumatic brain injury
Neuroinflammation
Lectin pathway
Complement cascade
MBL-associated serine protease
Neurological deficits
Pharmacological target

description: Funder: Ministero della Salute; doi: http://dx.doi.org/10.13039/501100003196
description: Abstract: The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We compared the long-term neurological deficits and neuropathology of wild-type mice (WT) to that of mice carrying gene deletions of key LP components after experimental TBI. WT or MASP-2 (Masp2−/−), ficolin-A (Fcna−/−), CL-11 (Colec11−/−), MASP-1/3 (Masp1−/−), MBL-C (Mbl2−/−), MBL-A (Mbl1−/−) or MBL−/− (Mbl1−/−/Mbl2−/−) deficient male C57BL/6J mice were used. Mice underwent sham surgery or TBI by controlled cortical impact. The sensorimotor response was evaluated by neuroscore and beam walk tests weekly for 4 weeks. To obtain a comparative analysis of the functional outcome each transgenic line was rated according to a health score calculated on sensorimotor performance. For selected genotypes, brains were harvested 6 weeks after injury for histopathological analysis. MASP-2−/−, MBL−/− and FCN-A−/− mice had better outcome scores compared to WT. Of these, MASP-2−/− mice had the best recovery after TBI, showing reduced sensorimotor deficits (by 33% at 3 weeks and by 36% at 4 weeks). They also showed higher neuronal density in the lesioned cortex with a 31.5% increase compared to WT. Measurement of LP functional activity in plasma from MASP-2−/− mice revealed the absence of LP functional activity using a C4b deposition assay. The LP critically contributes to the post-traumatic inflammatory pathology following TBI with the highest degree of protection achieved through the absence of the LP key enzyme MASP-2, underlining a therapeutic utility of MASP-2 targeting in TBI.
Shape Memory Polymer Resonators as Highly Sensitive Uncooled Infrared Detectors
Creators: name: Adiyan, Ulas
name: Larsen, Tom
name: Zarate, Juan Jose
name: Villanueva, Luis Guillermo
name: Shea, Herbert
Publisher: name: arXiv
Year: 2019
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Uncooled InfraRed (IR) detectors have enabled the rapid growth of thermal imaging applications. These detectors are predominantly bolometers, where the heating of pixel from incoming IR radiation is read out as a resistance change. Another uncooled sensing method is to transduce the IR radiation into the frequency shift of a mechanical resonator. We present here a highly sensitive, simple to fabricate resonant IR sensor, based on thermo-responsive Shape Memory Polymers (SMPs). By exploiting the phase-change polymer as the transduction mechanism, our approach provides 2 orders of magnitude improvement of the temperature coefficient of frequency (TCF). The SMP has very good absorption in IR wavelengths, obviating the need for an absorber layer. A Noise Equivalent Temperature Difference (NETD) of 22 mK in vacuum and 112 mK in air are obtained using f/2 optics. Such high performance in air eliminates the need for vacuum packaging, paving a path towards flexible IR sensors.
γ- Polyglutamic acid; Cellulose whiskers.pdf
Creators: name: Sinith Rashmin Withanage
name: Udara Ariyarathne
Publisher: name: figshare
Year: 2019
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: 30305 Polymerisation Mechanisms
subject: 30306 Synthesis of Materials

description: In this paper, mechanically stable and bio compatible γ- Poly glutamic acid (γ-PGA) and cellulose whiskers (Cellulose Nano crystals) hydrogel was prepared. γ-PGA/C-CNC hydrogel properties and characteristics were observed in different component ratios. The swelling degree of the hydrogel was observed in different solutions and different environments which is suggesting good swelling ability in water and pH 5 while holding chemically responsive abilities in ionic and phosphate buffer media. The mechanical strength was observed through pressuring ability test and stretching ability test to determine the hydrogel’s mechanical stability under strains and how it behave under certain tensions and strains. The SEM images have obtained and explains the chemical structure and the success of the chemical crosslinking procedure. And the micro porous structure was average 50μm in size of a single pore. From the properties such as biocompatibility, higher mechanical strength, and according to the swelling responses in different media, γ-PGA/C-CNC hydrogels take part in potential applications in different fields such as biomedical, cosmetic and clinical fields.
Listroderes brevisetis Hustache 1926
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes
Listroderes brevisetis

description: Listroderes brevisetis Hustache, 1926
 Listroderes brevisetis Hustache, 1926: 198 (type locality: Argentina: Chaco de Santiago del Estero; type material: S: 1 MNHN).
 Distribution. Central and southern Argentina (Morrone, 1993d).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 29, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Standard reference material (SRM) DNA barcode library approach for authenticating Antidesma bunius (L.) Spreng. (bignay) derived herbal medicinal products
Creators: name: Niña Kathryn G. Alfeche
name: Binag, Sam Dominic A.
name: Medecilo, Maria Melanie P.
name: Grecebio Jonathan D. Alejandro
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Science Policy
subject: Plant Biology

description: In the Philippines, the herbal medicinal product (HMP) market is flourishing due to the abundance of pharmacologically important species, and the high level of ethnomedicinal knowledge still widely accepted by the public. As such, herbal products from Antidesma bunius (L.) Spreng., locally known as bignay, are popular as medicine for various ailments of the circulatory and digestive systems. Though efficacy is guaranteed, the authenticity of the marketed products is still in question as several other herbal plants can provide the said benefits. Similar morphology between wild species also hinders species identification and contributes confusion especially to the general consumer. The authenticity of the marketed HMPs was established by means of DNA barcoding techniques which offers quick and reliable species identification by means of (1) the Basic Local Alignment Search Tool (BLASTn) and (2) the establishment of the first Standard Reference Material (SRM) Herbal barcode library for Antidesma spp. A total of 56 gene accessions from matK-psbA-trnH-rbcL sequences of 9 wild Antidesma spp. comprised the SRM which was then used to confirm the identity of 11 randomly sampled bignay-derived HMPs. Following the BLASTn and the SRM (maximum likelihood tree reconstruction) criterion, the subjected sequences revealed that only three of the 11 HMPs were authentic A. bunius-derived products. The other eight HMPs contained substitutes that were either fillers or different herbal medicinal plant not indicated in the product labels. These results indicate that product safety should be reinforced with complete HMP authentication using traditional methods supported by molecular data.
The magic carpet: an arbitrary spectrum wave maker for internal waves
Creators: name: Dobra, Thomas E.
name: Lawrie, Andrew G. W.
name: Dalziel, Stuart B.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Research Article

description: Abstract: We present a novel apparatus for generating internal waves of arbitrary size and shape, including both phase-locked and propagating waves. It is an actively driven, flexible “magic carpet” in the base of a tank. Our wave maker is computer-controlled to enable easy configuration. The actuation of a smooth, flexible surface produces clean waveforms with a predictable spectrum, for which we derive a theoretical model. We demonstrate the versatility of our wave maker through an experimental study of linear and nonlinear, isolated, and combined internal waves, including some that are sufficiently nonlinear to break remote from their source. Graphic abstract:
The Cloud Point Behaviors and the Liquid–Liquid Equilibrium of L31—Inorganic Sodium Salt Aqueous Two-Phase Systems
Creators: name: Cai, Yunfeng
name: Han, Juan
name: Wang, Yun
name: Wang, Lei
name: Li, Chunmei
name: Mao, Yanli
name: Ni, Liang
name: Zhang, Wenli
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Plant Biology

description: The cloud point (CP) of triblock-copolymer L31 aqueous solution was determined with salting-out salts (Na2SO4/Na2CO3/NaF/NaCl/NaBr). The results show that all these salts can decrease the CP of L31 aqueous solution and form aqueous two-phase system (ATPS). With increasing concentrations of Na2SO4 and Na2CO3, an obvious phase inversion could be observed and phase inversion points were found. This was mainly due to the change in density, the salt-rich phase shifted from the top phase to the bottom phase. Meanwhile, the liquid-liquid equilibrium (LLE) data for L31-Na2SO4/Na2CO3/NaF/NaCl/NaBr ATPSs were measured at 288.15 K. The salt ability to decrease the CP and to induce the phase separation is as follows: Na2SO4 > Na2CO3, NaF > NaCl > NaBr. Finally, the order of anions that reduced the CP and caused phase separation was obtained as follows: SO42− >CO32−, F− > Cl− > Br−.
Open Pharma position statement on open access
Creators: name: Sabir, Sarah
name: Winchester, Chris
name: Skobe, Catherine
name: Rains, Chris
name: Newman, Julie
name: Baltzer, Lise
name: Philippon, Valerie
Publisher: name: Open Pharma
Year: 2024
Subjects: classificationCode: 321403
subject: Clinical pharmacy and pharmacy practice
classificationCode: 350505
subject: Occupational and workplace health and safety
classificationCode: 420306
subject: Health care administration
classificationCode: 429999
subject: Other health sciences not elsewhere classified
classificationCode: 390113
subject: Science, technology and engineering curriculum and pedagogy

description: Open Pharma position statement on open access
Additional file 1 of OASI2: a cluster randomised hybrid evaluation of strategies for sustainable implementation of the Obstetric Anal Sphincter Injury Care Bundle in maternity units in Great Britain
Creators: name: Jurczuk, Magdalena
name: Posy Bidwell
name: Martinez, Dorian
name: Silverton, Louise
name: Van Der Meulen, Jan
name: Wolstenholme, Daniel
name: Ranee Thakar
name: Ipek Gurol-Urganci
name: Sevdalis, Nick
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Cardiology

description: Additional file 1. Theory of Change for OASI2
How Protons Shatter Colored Glass
Creators: name: Dumitru, Adrian
name: McLerran, Larry
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We consider the implications of the Color Glass Condensate for the central region of p+A collisions. We compute the k_t distribution of radiated gluons and their rapidity distribution dN/dy analytically, both in the perturbative regime and in the region between the two saturation momenta. We find an analytic expression for the number of produced gluons which is valid when the saturation momentum of the proton is much less than that of the nucleus. We discuss the scaling of the produced multiplicity with A. We show that the slope of the rapidity density dN/dy provides an experimental measure for the renormalization-group evolution of the color charge density of the Color Glass Condensate (CGC). We also argue that these results are easily generalized to collisions of nuclei of different A at central rapidity, or with the same A but at a rapidity far from the central region.
description: 9 pages, RevTex, 3 Figures; some typos corrected, the scaling of ^2 with dN/dy is derived
A Denotational Engineering of Programming Languages
Creators: name: Andrzej, Blikle
Publisher: name: arXiv
Year: 2019
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: 68N30

description: The book is devoted to two research areas: (1) Designing programming languages along with their denotational models. A denotational model of a language consists of two many-sorted algebras - an algebra of syntax and an algebra of denotations - and a (unique) homomorphism from syntax to denotations called the semantics of the language. (2) Designing sound program-constructors for languages with denotational models. In our approach programs syntactically contain their total-correctness specifications. A program is said to be correct if it is correct wrt its specification. A program-constructor is sound if given correct component-programs yields a correct resulting program. Both methods are illustrated on an example-language Lingua.
description: A preprint of a book; 340 pages. All comments will be highly appreciated. You may write to me on andrzej.blikle@moznainaczej.com.pl
A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1
Creators: name: Thiebaud, Nicolas
name: Gribble, Fiona
name: Reimann, Frank
name: Trapp, Stefan
name: Fadool, Debra Ann
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/378/2624/1703
/631/378/3917
/9/74
/14
/14/1
/14/19
/14/34
/14/63
/13/51
article

description: Abstract: The presence of large numbers of local interneurons in the olfactory bulb has demonstrated an extensive local signaling process, yet the identification and purpose of olfactory microcircuits is poorly explored. Because the discrimination of odors in a complex environment is highly dependent on the tuning of information by local interneurons, we studied for the first time the role of preproglucagon (PPG) neurons in the granule cell layer of the olfactory bulb. Combining electrophysiological recordings and confocal microscopy, we discovered that the PPG neurons are a population of cells expressing the precursor of glucagon-like peptide 1 and are glutamatergic; able to modulate the firing pattern of the mitral cells (M/TCs). Optogenetic activation of PPG neurons resulted in a mixed excitation and inhibition that created a multiphasic response shaping the M/TCs firing pattern. This suggests that PPG neurons could drive neuromodulation of the olfactory output and change the synaptic map regulating olfactory coding.
On Real-oriented Johnson-Wilson cohomology
Creators: name: Hu, Po
Publisher: name: arXiv
Year: 2002
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55P42, 55P91, 55T25

description: Answering a question of W. S. Wilson, I introduce a Z/2-equivariant Atiyah-Real analogue of Johnson-Wilson cohomology theory BP, whose coefficient ring is the =< n-chromatic part of Landweber's Real cobordism ring.
description: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol2/agt-2-38.abs.html
Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper
Creators: name: Oc, Sebnem
name: Eraslan, Serpil
name: Kirdar, Betul
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/114
/631/553
/631/1647/2017/2079
article

description: Abstract: Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper homeostatic systems between human and Saccharomyces cerevisiae made this organism a suitable model organism for elucidating molecular mechanisms of copper transport and homeostasis. In this study, the dynamic transcriptional response of both the reference strain and homozygous deletion mutant strain of CCC2, which encodes a Cu2+-transporting P-type ATPase, were investigated following the introduction of copper impulse to reach a copper concentration which was shown to improve the respiration capacity of CCC2 deletion mutants. The analysis of data by using different clustering algorithms revealed significantly affected processes and pathways in response to a switch from copper deficient environment to elevated copper levels. Sulfur compound, methionine and cysteine biosynthetic processes were identified as significantly affected processes for the first time in this study. Stress response, cellular response to DNA damage, iron ion homeostasis, ubiquitin dependent proteolysis, autophagy and regulation of macroautophagy, DNA repair and replication, as well as organization of mitochondrial respiratory chain complex IV, mitochondrial organization and translation were identified as significantly affected processes in only CCC2 deleted strain. The integration of the transcriptomic data with regulome revealed the differences in the extensive re-wiring of dynamic transcriptional organization and regulation in these strains.
Does the Choice of Metric Matter for Identifying Areas for Policy Priority? An Empirical Assessment Using Child Undernutrition in India
Creators: name: Rajpal, Sunil
name: Kim, Rockli
name: Liou, Lathan
name: Joe, William
name: Subramanian, S. V.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Research
Child-undernutrition
Prevalence
Stunting
Wasting
Underweight
Anemia
India

description: Abstract: Ratio-based prevalence and absolute headcounts are the two most commonly accepted metrics to measure the burden of various socioeconomic phenomenon. However, ratio-based prevalence, calculated as the number of cases with certain conditions relative to the total population, is by far the most widely used to rank burden and consequently for targeting, across different populations, often defined in terms of geographical areas. In this regard, targeting areas exclusively based on prevalence-based metric poses certain fundamental difficulties with some serious policy implications. Drawing the data from the National Family Health Survey 2015–2016, and Census 2011, this paper takes four indicators of child undernutrition in India as an example to examine two contextual questions: first, does the choice of metric matter for targeting areas for reducing child undernutrition in India? and second; which metric should be used to facilitate comparisons and targeting across variable populations? Our findings suggest a moderate correlation between prevalence estimates and absolute headcounts implying that choice of metric does matter when targeting child undernutrition. Huge variations were observed between prevalence-based and absolute count-based ranking of the districts. In fact, in various cases, districts with the highest absolute number of undernourished children were ranked as relatively lower-burden districts based on prevalence. A simple comparison between the two approaches—when applied to targeting undernourished children in India—indicates that prevalence-based prioritization may miss high-burden areas where substantially higher number of undernourished children are concentrated. For developing populous countries like India, which is already grappling with high levels of maternal and child malnutrition and poor health infrastructure along with intrinsic socioeconomic inequalities, it is critical to adopt an appropriate metric for effective targeting and prioritization.
An Updated Review of Methods and Advancements in Microvascular Blood Flow Imaging
Creators: name: Lal, Cerine
name: Leahy, Martin J
Publisher: name: arXiv
Year: 2019
Subjects: subject: Medical Physics (physics.med-ph)
subject: Image and Video Processing (eess.IV)
subject: Biological Physics (physics.bio-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: There has been a consistent growth in research involving imaging of microvasculature over the past few decades. By 2008, publications mentioning the microcirculation had grown more than 2000 per annum. Many techniques have been demonstrated for measurement of the microcirculation ranging from the earliest invasive techniques to the present high speed, high resolution non-invasive imaging techniques. Understanding the microvasculature is vital in tackling fundamental research questions as well as to understand effects of disease progression on the physiological wellbeing of an individual. We have previously provided a wide ranging review [38] covering most of the available techniques and their applications. In this review, we discuss the recent advances made and applications in the field of microcirculation imaging.
Additional file 2 of OASI2: a cluster randomised hybrid evaluation of strategies for sustainable implementation of the Obstetric Anal Sphincter Injury Care Bundle in maternity units in Great Britain
Creators: name: Jurczuk, Magdalena
name: Posy Bidwell
name: Martinez, Dorian
name: Silverton, Louise
name: Van Der Meulen, Jan
name: Wolstenholme, Daniel
name: Ranee Thakar
name: Ipek Gurol-Urganci
name: Sevdalis, Nick
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Cardiology

description: Additional file 2. Summary of data specification for the OASI2 project
Listroderes bruchi Hustache 1926
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes
Listroderes bruchi

description: Listroderes bruchi Hustache, 1926
 Listroderes bruchi Hustache, 1926: 197 (type locality: Argentina: Catamarca, Hualfín; type material: H: MNHN and P: 4 MACN).
 Immature stages. Larva (Marvaldi, 1998).
 Host plants. Baccharis salicifolia (Ruiz and Pavón) Pers. and Senecio subulatus Don Hooker et Arnott (Asteraceae) (Morrone, 1993d; Marvaldi, 1998).
 Distribution. Western Argentina (Morrone, 1993d).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 29, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
A Topological Nomenclature for 3D Shape Analysis in Connectomics
Creators: name: Talwar, Abhimanyu
name: Lin, Zudi
name: Wei, Donglai
name: Wu, Yuesong
name: Zheng, Bowen
name: Zhao, Jinglin
name: Jang, Won-Dong
name: Wang, Xueying
name: Lichtman, Jeff W.
name: Pfister, Hanspeter
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: One of the essential tasks in connectomics is the morphology analysis of neurons and organelles like mitochondria to shed light on their biological properties. However, these biological objects often have tangled parts or complex branching patterns, which make it hard to abstract, categorize, and manipulate their morphology. In this paper, we develop a novel topological nomenclature system to name these objects like the appellation for chemical compounds to promote neuroscience analysis based on their skeletal structures. We first convert the volumetric representation into the topology-preserving reduced graph to untangle the objects. Next, we develop nomenclature rules for pyramidal neurons and mitochondria from the reduced graph and finally learn the feature embedding for shape manipulation. In ablation studies, we quantitatively show that graphs generated by our proposed method align with the perception of experts. On 3D shape retrieval and decomposition tasks, we qualitatively demonstrate that the encoded topological nomenclature features achieve better results than state-of-the-art shape descriptors. To advance neuroscience, we will release a 3D segmentation dataset of mitochondria and pyramidal neurons reconstructed from a 100um cube electron microscopy volume with their reduced graph and topological nomenclature annotations. Code is publicly available at https://github.com/donglaiw/ibexHelper.
description: Technical report
Public attitudes towards screening for kidney cancer: an online survey
Creators: name: Harvey-Kelly, Laragh L. W.
name: Harrison, Hannah
name: Rossi, Sabrina H.
name: Griffin, Simon J.
name: Stewart, Grant D.
name: Usher-Smith, Juliet A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Urological oncology
Attitudes
Kidney cancer
Cancer
Screening
Survey

description: Funder: Kidney Cancer UK
description: Funder: The Urology Foundation
description: Abstract: Background: Kidney cancer is often asymptomatic, leading to proposals for a screening programme. The views of the public towards introducing a new screening programme for kidney cancer are unknown. The aim of this study was to explore attitudes towards kidney cancer screening and factors influencing intention to attend a future screening programme. Methods: We conducted an online population-based survey of 1021 adults aged 45–77 years. The main outcome measure was intention to attend four possible screening tests (urine, blood, ultrasound scan, low-dose CT) as well as extended low-dose CT scans within lung cancer screening programmes. We used multivariable regression to examine the association between intention and each screening test. Results: Most participants stated that they would be ‘very likely’ or ‘likely’ to undergo each of the screening tests [urine test: n = 961 (94.1%); blood test: n = 922 (90.3%); ultrasound: n = 914 (89.5%); low-dose CT: n = 804 (78.8%); lung CT: n = 962 (95.2%)]. Greater intention to attend was associated with higher general cancer worry and less perceived burden/inconvenience about the screening tests. Less worry about the screening test was also associated with higher intention to attend, but only in those with low general cancer worry (cancer worry scale ≤ 5). Compared with intention to take up screening with a urine test, participants were half as likely to report that they intended to undergo blood [OR 0.56 (0.43–0.73)] or ultrasound [OR 0.50 (0.38–0.67)] testing, and half as likely again to report that they intended to take part in a screening programme featuring a low dose CT scan for kidney cancer screening alone [OR 0.19 (0.14–0.27)]. Conclusion: Participants in this study expressed high levels of intention to accept an invitation to screening for kidney cancer, both within a kidney cancer specific screening programme and in conjunction with lung cancer screening. The choice of screening test is likely to influence uptake. Together these findings support on-going research into kidney cancer screening tests and the potential for combining kidney cancer screening with existing or new screening programmes.
Comparing Supply Systems Derived from a Symmetric Generalized McFadden Profit Function to Isoelastic Supply Systems: Costs and Benefits
Creators: name: Grethe, Harald
name: Weber, Gerald
name: Grethe, Harald
name: Weber, Gerald
Publisher: name: Unknown
Year: 2005
Subjects: Agricultural and Food Policy
Research Methods/ Statistical Methods

description: A major drawback of constant elasticity supply and demand systems, which are widely used in simulation models for applied policy analysis, is that they can’t be restricted to globally comply with certain conditions implied by economic theory. This paper compares constant elasticity systems to supply and demand systems derived from second order flexible functional forms (FFFs). Furthermore, supply systems in the model CEEC-ASIM, which are derived from a specific FFF, the Symmetric Generalized McFadden (SGMF) profit function, are assessed and compared to constant elasticity supply specifications which exhibit the same supply elasticities at the point of calibration.
Color-Flavor Unlocking and Phase Diagram with Self-Consistently Determined Strange Quark Masses
Creators: name: Buballa, M.
name: Oertel, M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The phase diagram of strongly interacting matter at non-zero temperature and baryon chemical potential is calculated within a 3-flavor NJL-type quark model with realistic quark masses. The model exhibits spontaneous chiral symmetry breaking as well as diquark condensation in the two-flavor color-superconducting phase and in the color-flavor locked phase. We investigate the color-flavor unlocking phase transition, taking into account self-consistently calculated effective quark masses. We find that it is mainly triggered by a first order phase transition with respect to the strange quark mass. It takes place at much higher values of the chemical potential than the transition to the hadronic phase such that we find a relatively large region in the phase diagram where the two-flavor color-superconductor seems to be the most favored state.
description: 16 pages, 5 figures; v2: figure 2 of v1 removed, some changes in the discussion, references added
Influence of spatial dispersion on surface plasmons, nanoparticles and grating couplers
Creators: name: Pitelet, Armel
name: Centeno, Emmanuel
name: Moreau, Antoine
name: Schmitt, Nikolai
name: Scheid, Claire
name: Loukrezis, Dimitrios
name: De Gersem, Herbert
name: Ciraci, Cristian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent experiments have shown that spatial dispersion may have a conspicuous impact on the response of plasmonic structures. This suggests that in some cases the Drude model should be replaced by more advanced descriptions that take spatial dispersion into account, like the hydrodynamic model. Here we show that nonlocality in the metallic response affects surface plasmons propagating at the interface between a metal and a dielectric with high permittivity. As a direct consequence, any nanoparticle with a radius larger than 20 nm can be expected to be sensitive to spatial dispersion whatever its size. The same behavior is expected for a simple metallic grating allowing the excitation of surface plasmons, just as in Wood's famous experiments. Importantly, our work suggests that for any plasmonic structure in a high permittivity dielectric, nonlocality should be taken into account.
dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction
Creators: name: Kaminskas, Lisa M.
name: Pires, Douglas E. V.
name: Ascher, David B.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/114/2397
/631/114/129
/631/114/1305
/119
article

description: Abstract: Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of dendrimers, a commonly explored drug vector, based on physicochemical properties. We have manually curated the largest relational database of dendrimer pharmacokinetic parameters and their structural/physicochemical properties. This was used to develop a machine learning-based model capable of accurately predicting pharmacokinetic parameters, including half-life, clearance, volume of distribution and dose recovered in the liver and urine. dendPoint successfully predicts dendrimer pharmacokinetic properties, achieving correlations of up to r = 0.83 and Q2 up to 0.68. dendPoint is freely available as a user-friendly web-service and database at http://biosig.unimelb.edu.au/dendpoint. This platform is ultimately expected to be used to guide dendrimer construct design and refinement prior to embarking on more time consuming and expensive in vivo testing.
Additional file 1 of Multi-disciplinary supportive end of life care in long-term care: an integrative approach to improving end of life
Creators: name: Harasym, Patricia M.
name: Afzaal, Misha
name: Brisbin, Sarah
name: Aynharan Sinnarajah
name: Venturato, Lorraine
name: Quail, Patrick
name: Kaasalainen, Sharon
name: Straus, Sharon
name: Sussman, Tamara
name: Navjot Virk
name: Jayna M. Holroyd-Leduc
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1.
Rural Industrialization - Analysis of Characteristics and an Approach to the Selection of Industrial Plants for Kibbutz Settlements in Israel
Creators: name: Yaron, D.
name: Cooper, A.
name: Golan, D.
name: Reisman, A.
name: Yaron, D.
name: Cooper, A.
name: Golan, D.
name: Reisman, A.
Publisher: name: Unknown
Year: 1982
Subjects: Industrial Organization

description: A major problem related to rural industrialization is the selection of the types of industrial plants suitable for rural communities and their matching with resource potential and preferences of specific communities. This paper presents a methodology developed to cope with this problem and its empirical application to collective rural settlements in Israel.
On Mirror Maps for Manifolds of Exceptional Holonomy
Creators: name: Braun, Andreas P.
name: Majumder, Suvajit
name: Otto, Alexander
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study mirror symmetry of type II strings on manifolds with the exceptional holonomy groups $G_2$ and Spin(7). Our central result is a construction of mirrors of Spin(7) manifolds realized as generalized connected sums. In parallel to twisted connected sum $G_2$ manifolds, mirrors of such Spin(7) manifolds can be found by applying mirror symmetry to the pair of non-compact manifolds they are glued from. To provide non-trivial checks for such geometric mirror constructions, we give a CFT analysis of mirror maps for Joyce orbifolds in several new instances for both the Spin(7) and the $G_2$ case. For all of these models we find possible assignments of discrete torsion phases, work out the action of mirror symmetry, and confirm the consistency with the geometrical construction. A novel feature appearing in the examples we analyse is the possibility of frozen singularities.
description: 45 pages
Validation of an analytical method using HS-SPME-GC/MS-SIM to assess the exposure risk to carbonyl compounds and furan derivatives through beer consumption
Creators: name: Hernandes, Karolina C.
name: Érica A. Souza-Silva
name: Assumpção, Carolina F.
name: Zini, Claudia A.
name: Welke, Juliane E.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Compounds with toxic potential may occur in beer, such as carbonyl compounds (acetaldehyde, acrolein, ethyl carbamate [EC] and formaldehyde) and furan derivatives [furfural and furfuryl alcohol (FA)]. The objective of this study was, for the first time, to validate a method based on headspace-solid phase microextraction using a PDMS-overcoated fibre and gas chromatography with mass spectrometric detection in selected ion monitoring mode (HS-SPME-GC/MS-SIM) to investigate target carbonyl compounds and furan derivatives in beers. Analytical curves showed proper linearity with r2 ranging from 0.9731 to 0.9960 for acetaldehyde and EC, respectively. The lowest LOD was found for acetaldehyde (0.03 µg L−1), while the lowest LOQ value (1.0 µg L−1) was found for acetaldehyde and EC, formaldehyde and furfural. Recovery (90% to 105%), intermediate precision and repeatability (lower than 13%), limits of detection and quantification (values below 2.5 μg L−1) showed that the method is suitable to simultaneously quantify these compounds. EC was detected in only two samples (1 lager and 1 ale). Furfural was found in 37% and 82% of ale and lager beers, respectively. Acetaldehyde, acrolein, formaldehyde and FA were detected in all samples. However, acrolein was the only compound found in the commercial samples at a concentration capable of causing health risk. Besides furfural and FA, four other furan-containing compounds (5-methyl-2-furan methanethiol, acetylfuran, 5-methylfurfural and γ-nonalactone) were also found in beers, however, at levels low enough not to impose potential health risk.
Learning Rotation Adaptive Correlation Filters in Robust Visual Object Tracking
Creators: name: Rout, Litu
name: Raju, Priya Mariam
name: Mishra, Deepak
name: Gorthi, Rama Krishna Sai Subrahmanyam
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Visual object tracking is one of the major challenges in the field of computer vision. Correlation Filter (CF) trackers are one of the most widely used categories in tracking. Though numerous tracking algorithms based on CFs are available today, most of them fail to efficiently detect the object in an unconstrained environment with dynamically changing object appearance. In order to tackle such challenges, the existing strategies often rely on a particular set of algorithms. Here, we propose a robust framework that offers the provision to incorporate illumination and rotation invariance in the standard Discriminative Correlation Filter (DCF) formulation. We also supervise the detection stage of DCF trackers by eliminating false positives in the convolution response map. Further, we demonstrate the impact of displacement consistency on CF trackers. The generality and efficiency of the proposed framework is illustrated by integrating our contributions into two state-of-the-art CF trackers: SRDCF and ECO. As per the comprehensive experiments on the VOT2016 dataset, our top trackers show substantial improvement of 14.7% and 6.41% in robustness, 11.4% and 1.71% in Average Expected Overlap (AEO) over the baseline SRDCF and ECO, respectively.
description: Published in ACCV 2018
A Review of Permeability and Flow Simulation for Liquid Composite Moulding of Plant Fibre Composites
Creators: name: Pantaloni, Delphin
name: Bourmaud, Alain
name: Baley, Christophe
name: Clifford, Mike J.
name: Ramage, Michael H.
name: Shah, Darshil U.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: polymer matrix composites (PMCs)
liquid composite moulding (LCM)
resin transfer moulding (RTM)
permeability
flow modelling
natural fibres
biocomposites

description: Liquid composite moulding (LCM) of plant fibre composites has gained much attention for the development of structural biobased composites. To produce quality composites, better understanding of the resin impregnation process and flow behaviour in plant fibre reinforcements is vital. By reviewing the literature, we aim to identify key plant fibre reinforcement-specific factors that influence, if not govern, the mould filling stage during LCM of plant fibre composites. In particular, the differences in structure (physical and biochemical) for plant and synthetic fibres, their semi-products (i.e., yarns and rovings), and their mats and textiles are shown to have a perceptible effect on their compaction, in-plane permeability, and processing via LCM. In addition to examining the effects of dual-scale flow, resin absorption, (subsequent) fibre swelling, capillarity, and time-dependent saturated and unsaturated permeability that are specific to plant fibre reinforcements, we also review the various models utilised to predict and simulate resin impregnation during LCM of plant fibre composites.
Washing with the Gods Exhibition Catalogue
Creators: name: Green, James
Publisher: name: Cardiff Metropolitan University
Year: 2019
Subjects: subject: 190502 Fine Arts (incl. Sculpture and Painting)
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: Art

description: Most people are familiar with bars of soap and probably use them every day without thinking about them. Soap is one of the mundane objects that form part of our everyday lives. Generally, a normal bar of soap will cost between fifty pence to about three pounds depending on where you shop and is made from a mixture of fat or lard, oil, lye and chemicals that make it smell nice. It’s main function is to wash grease and dirt away from the surface of the body. Or so I thought until I was introduced to Magic Soap. Magic Soaps (commonly known in Spanish as Jabon Esoterico) are bars of soap that are sold at Tiendas Esoterica1 (stalls that sell items associated with magic) in the inner-city markets of Central and South America and Spain. Unlike regular bars of soap, Magic Soaps draw on the powers of a range of beings (gods, sacred objects, animals, folk saints), which, if applied directly, will make a user’s chosen desire come true. They are presented in visually striking packages that are illustrated with pictures that either show the circumstances that led to the Magic Soap being used (e.g. a person being frightened by evil magic), the results the Magic Soap produces (e.g. a woman dominating her wayward husband on page 15), or the being whose powers the Magic Soap calls upon (e.g. a folk saint of Guatemala on page 26). Magic Soap often comes with small prayer cards that provide instructions for the user to ensure best results and some have small charms, talismans or seeds mixed in to them. Washing with the Gods, held at the Museum of Witchcraft and Magic, home to one of the World’s largest collections of items related to European magic and the occult, exhibits Magic Soaps collected from Ecuador, Colombia, Perú, Chile, Mexico and Spain between 2015 to 2019. The Magic Soaps displayed here form possibly the largest collection of its kind and exhibiting them at the Museum of Witchcraft and Magic will reveal new insights into the links between European and Latin American magic, and how household magic is used today. Even though there is literature that already deals with these subjects, Magic Soaps have been over looked and this exhibition aims to bring them to the fore and to begin a discussion of how the images on their packages contribute to the history of how ideas of magic from Europe and indigenous groups of Central and South America merged.
Washing with the Gods was exhibited at the Museum of Witchcraft and Magic, Boscastle 20 July - 20th September 2019.
The Physical Origin of the Scattering Polarization of the Na I D-Lines in the Presence of Weak Magnetic Fields
Creators: name: Trujillo-Bueno, Javier
name: Casini, Roberto
name: Landolfi, Marco
name: Degl'Innocenti, Egidio Landi
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We demonstrate that the atomic alignment of the hyperfine-structure components of the ground level S$_{1/2}$ of Na {\sc i} and of the upper level P$_{1/2}$ of the D$_1$ line are practically negligible for magnetic strengths $B>10 \rm G$, and virtually zero for $B\ga 100 \rm G$. This occurs independently of the magnetic-field inclination on the stellar surface (also, in particular, for vertical fields). Consequently, the characteristic antisymmetric linear-polarization signature of the scattered light in the D$_1$ line is practically suppressed in the presence of magnetic fields larger than 10 G, regardless of their inclination. Remarkably, we find that the scattering polarization amplitude of the D$_2$ line increases steadily with the magnetic strength, for vertical fields above 10 G, while the contribution of alignment to the polarization of the D$_1$ line rapidly decreases. Therefore, we suggest that spectropolarimetric observations of the ``quiet'' solar chromosphere showing significant linear polarization peaks in both D$_1$ and D$_2$ cannot be interpreted in terms of one-component magnetic field models, implying that the magnetic structuring of the solar chromosphere could be substantially more complex than previously thought.
description: 11 pages and 2 figures. The Astrophysical Journal Letter (in press)
Listroderes charybdis Morrone 1993
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes
Listroderes charybdis

description: Listroderes charybdis Morrone, 1993
 Listroderes charybdis Morrone, 1993d: 281 (type locality: Argentina: Corrientes, Santo Tomé; type material: H: MACN and P: 1 MACN and 1 MLP).
 Distribution. Northeastern Argentina (Morrone, 1993d).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 29, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257