cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Within-Person Approach to Risk for Suicidal Ideation and Suicidal Behavior: Examining the Roles of Depression, Stress, and Abuse Exposure
Creators: name: Giletta, Matteo
name: Miller, Adam Bryant
name: Rudolph, Karen D.
name: Nock, Matthew K.
name: Hastings, Paul D.
name: Eisenlohr-Moul, Tory
name: Prinstein, Mitchell J.
Publisher: name: American Psychological Association (APA)
Year: 2017

description: OBJECTIVE: This study tests a novel, within-person model that reexamines depression and stress as risk factors for suicidal ideation and behavior among adolescent girls with and without sexual/physical abuse histories. METHOD: This longitudinal study includes data from 220 adolescent girls between 12 and 16 years of age (M = 14.69 years, SD = 1.37; 61% White). At baseline, adolescents reported the presence or absence of prior abuse as part of a clinical interview. At baseline and every 3 months for 18 months, adolescents completed measures of suicidal ideation and behavior, depressive symptoms, and stress. RESULTS: Multilevel models examined within-person mean, deviations from within-person mean, depression, and stress and their interactions with abuse as predictors of suicidal ideation and behavior. In addition to within-person mean depression, higher-than-usual depression (odds ratio [OR] = 1.99) and higher-than-usual stress (OR = 1.53) predicted greater risk of suicidal ideation at each follow-up assessment. Periods of higher-than-usual stress (1 SD increase) and periods of higher-than-usual depression (1 SD increase) were associated with an 82% and 57% increase in the odds of suicidal behavior, respectively, but only among those with abuse histories. CONCLUSION: Depression, stress, and abuse are well-known risk factors for suicidal ideation and behavior; however, it has been unclear for whom, and when, these factors have their greatest impact. These results show that depression and stress are potent risk factors among those with a history of abuse and that within-person elevations in these risk factors signal increased short-term risk of suicidal ideation and behavior.
Additional file 1 of Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial
Creators: name: Yoon, Jeong Hee
name: Park, Jin Young
name: Lee, Sang Min
name: Lee, Eun Sun
name: Kim, Jae Hyun
name: Lee, Jeong Min
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Cell Biology
Pharmacology
Marine Biology

description: Supplementary Material 1
SOLUTIONS DE LA NORME ISO 9001 AU DEFI DE LA PERFORMANCE ORGANISATIONNELLE DE LA PMI : MODELE CONCEPTUEL ET CONSTATS RELATIFS AU CONTEXTE MAROCAIN
Creators: name: AYYADI, Ismail
name: OULHADJ, Badia
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: PMI, the international standard ISO 9001, organizational performance, narrative literature review, conceptual model.

description: La Petite et Moyenne Industrie est l’un des acteurs stratégiques du développement socio-économique des pays développés et en voie de développement. Le défi de la performance organisationnelle ou le passage à la version intégrée des performances financières et non-financières, ne se limite guère à la Grande Industrie, mais concerne au même pied d’égalité la PMI. La norme internationale ISO 9001, qui décrit les exigences à respecter pour le développement d’un système de management de la qualité, représente selon l’Organisation Internationale de Normalisation l’une des réponses à ce défi. Après une revue de littérature narrative composée de 11 études empiriques internationales et 4 autres relatives au contexte marocain, justifient que des bénéfices économiques, sociaux, environnementaux et autres, peuvent découler de l’intégration et de la certification à la norme ISO 9001. Toutefois, différents auteurs tirent l’intention des organisations à prendre en considération de l’aspect managérial de la norme ISO 9001 en parallèle avec celui de la certification, pour que l’impact de la norme ISO 9001 sur la performance organisationnelle soit plus significatif.
description: Revue Economie, Gestion et Société, No 5 (2016)
Chemical toxicity prediction for major classes of industrial chemicals: Is it possible to develop universal models covering cosmetics, drugs, and pesticides?
Creators: name: Muratov, Nail N.
name: Alves, Vinicius M.
name: Tropsha, Alexander
name: Zakharov, Alexey
name: Andrade, Carolina H.
name: Muratov, Eugene N.
Publisher: name: Elsevier
Year: 2017

description: Computational models have earned broad acceptance for assessing chemical toxicity during early stages of drug discovery or environmental safety assessment. The majority of publicly available QSAR toxicity models have been developed for datasets including mostly drugs or drug-like compounds. We have evaluated and compared chemical spaces occupied by cosmetics, drugs, and pesticides, and explored whether current computational models of toxicity endpoints can be universally applied to all these chemicals. Our analysis of the chemical space overlap and applicability domain (AD) of models built previously for twenty different toxicity endpoints showed that most of these models afforded high coverage (>90%) for all three classes of compounds analyzed herein. Only T. pyriformis models demonstrated lower coverage for drugs and pesticides (38% and 54%, respectively). These results show that, for the most part, historical QSAR models built with data available for different toxicity endpoints can be used for toxicity assessment of novel chemicals irrespective of the intended commercial use; however, the AD restriction is necessary to assure the expected prediction accuracy. Local models may need to be developed to capture chemicals that appear as outliers with respect to global models.
Mikrobiologiczne procesy utleniania kopalnej materii organicznej miedzionośnego łupka bitumicznego Kupferschiefer (monoklina przedsudecka)
Creators: name: Włodarczyk, Agnieszka
name: Matlakowska, Renata
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: łupek miedzionośny, bitumiczny

description: Łupek miedzionośny III, Kowalczuk P.B., Drzymała J. (red.), WGGG PWr, Wrocław, ISBN 978-83-946706-0-3
Additional file 1 of How and to what extent did the Coventry City of Culture ‘City Host’ volunteer programme affect the volunteers’ mental wellbeing? A qualitative study
Creators: name: Whelan, Maxine
name: Ghosh, Iman
name: Bell, Lauren
name: Oyebode, Oyinlola
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 1
LA GOUVERNANCE MULTI-SOCIETAIRE : QUELLES AVENUES AUX DEFIS DES COOPERATIVES FEMININES ?
Creators: name: OULHADJ, Badia
name: EL AARROUMI, Asma
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: Women Cooperative Governance, Multi-company, Empowerment, Deliberative Democracy.

description: Afin d’assurer leur pérennité, les coopératives se trouvent dans la nécessité de gérer d’inévitables tensions entre leur statut d’entreprise créatrice de richesse et leur vocation environnementale et sociale[1]. Toutes ces fonctions ne peuvent être réalisées que si les membres de la coopérative prennent en considération dans leur gestion les principes de la bonne gouvernance. L’ouverture des structures de gouvernance aux parties prenantes représente aujourd’hui une forme de gouvernance renouvelée qui devient de plus en plus nécessaire pour garantir l’émergence du modèle coopératif et lui éviter de devenir une langue morte. L’approche de la démocratie délibérative sur laquelle se base ce modèle, représente une façon de produire des choix et des décisions éclairées et validées socialement. Notre objectif est d’étudier la contribution de la pratique de démocratie délibérative proposée dans le cadre du modèle multi-sociétaire au renforcement « Empowerment » des coopératives féminines. [1]Jean-Yves M, Leroy G. (2002), Développement durable: doctrines, pratiques, évaluations, IRD Editions.
description: Revue Economie, Gestion et Société, No 5 (2016)
Właściwości łupka miedziowego z rejonu LGOM
Creators: name: Ratajczak, Tomasz
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: łupek miedzionośny, LGOM

description: Łupek miedzionośny III, Kowalczuk P.B., Drzymała J. (red.), WGGG PWr, Wrocław, ISBN 978-83-946706-0-3
Stimulating Patient Engagement in Medical Device Development in Kidney Disease: A Report of a Kidney Health Initiative Workshop
Creators: name: Hill, Terri
name: Lee, Celeste Castillo
name: Upchurch, Linda
name: Fisher, Benjamin R.
name: Chianchiano, Dolph
name: Neuland, Carolyn Y.
name: Flythe, Jennifer E.
name: Hurst, Frank P.
Publisher: name: Elsevier
Year: 2017

description: New technologies challenge current dialysis treatment paradigms as devices become smaller, more portable, and increasingly used outside the dialysis clinic. It is unclear how patients will view this care transition, and it will be important to consider patient and care partner perspectives during all aspects of development for novel dialysis therapies, from design and clinical trials to regulatory approval. To gain insight into this area, the Kidney Health Initiative, a public-private partnership between the American Society of Nephrology, the US Food and Drug Administration, and nearly 80 member organizations and companies dedicated to enhancing patient safety and fostering innovation in kidney disease, convened a workshop of patients, care partners, and other kidney community stakeholders. The workshop included background presentations followed by focused small group discussions in 3 areas (device design, clinical trials, and regulatory approval). Participants explored how to involve patients throughout the life cycle of a medical device, including discussions of how patients can influence device design, assist in the planning and implementation of clinical trials, and provide input to affect regulatory decisions. Patients were engaged in the workshop discussion and interested in sharing their perspectives, but they recommended additional efforts around education, communication, and outreach in these areas.
Próba klasyfikacji łupków Legnicko-Głogowskiego Okręgu Miedziowego na podstawie zawartości węglanów, minerałów ilastych, węgla organicznego oraz miedzi
Creators: name: Drzymała, Jan
name: Karwowski, Piotr
name: Borowski, Kamil
name: Pązik, Paulina M.
name: Kowalczuk, Przemysław B.
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: łupek miedzionośny, węglany, węgiel organiczny

description: Łupek miedzionośny III, Kowalczuk P.B., Drzymała J. (red.), WGGG PWr, Wrocław, ISBN 978-83-946706-0-3
LA THEORIE DU COMPROMIS A L’EPREUVE DES FAITS : DEBAT EN QUESTION
Creators: name: RAFIKI, Abdekjabar
name: RACHIDI, Moulay Ali
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: Arbitration; compromise; financial structure ; target ratio.

description: Cet article présente une synthèse de la littérature empirique traitant de la question des déterminants de la structure financière des entreprises dans l’optique de la théorie du compromis. Il tend à mettre en évidence les controverses empiriques mettant à l’épreuve des faits les arguments de la théorie. Les arguments théoriques soumis aux tests empiriques sont souvent la fiscalité, les coûts de faillite, le risque financier et économique, la taille, les garanties, l’âge de l’entreprise, la croissance, la tangibilité des actifs, la rentabilité et le secteur d’activité. Les preuves empiriques ont montré des résultats souvent mitigés, en conséquence l’inexistence d’un modèle standard capable de rendre compte simultanément de tous les faits stylisés, ce qui a permis l’émergence d’autres théories d’arbitrage plus pertinentes.
description: Revue Economie, Gestion et Société, No 5 (2016)
sj-docx-1-mso-10.1177_20552173221093219 - Supplemental material for The socioeconomic impact of multiple sclerosis in France: Results from the PETALS study
Creators: name: Bouleau, A
name: Dulong, C
name: Schwerer, CA
name: Delgrange, R
name: Bouaou, K
name: Brochu, T
name: Zinai, S
name: Švecová, K
name: Sá, MJ
name: Petropoulos, A
name: Aly, S
name: Labauge, P
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-mso-10.1177_20552173221093219 for The socioeconomic impact of multiple sclerosis in France: Results from the PETALS study by A Bouleau, C Dulong, CA Schwerer, R Delgrange, K Bouaou, T Brochu, S Zinai, K Švecová, MJ Sá, A Petropoulos, S Aly and P Labauge in Multiple Sclerosis Journal – Experimental, Translational and Clinical
Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood
Creators: name: Shih, Yen-Yu Ian
name: Crews, Fulton T.
name: Lee, Sung-Ho
name: Robinson, Donita L.
name: Broadwater, Margaret A.
name: Yu, Yang
name: Zhu, Hongtu
Publisher: name: Wiley
Year: 2017

description: Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with emergence of adult executive function and top-down inhibitory control over behavior. Alcohol exposure during this critical period of brain maturation may affect development of PFC and frontolimbic connectivity. Adult rats exposed to adolescent intermittent ethanol (AIE; 5 g/kg ethanol, 25 percent v/v in water, intragastrically, 2-day-on, 2-day-off, postnatal day 25-54) or water control underwent resting-state functional MRI to test the hypothesis that AIE induces persistent changes in frontolimbic functional connectivity under baseline and acute alcohol conditions (2 g/kg ethanol or saline, intraperitoneally administered during scanning). Data were acquired on a Bruker 9.4-T MR scanner with rats under dexmedetomidine sedation in combination with isoflurane. Frontolimbic network regions-of-interest for data analysis included PFC [prelimbic (PrL), infralimbic (IL), and orbitofrontal cortex (OFC) portions], nucleus accumbens (NAc), caudate putamen (CPu), dorsal hippocampus, ventral tegmental area, amygdala, and somatosensory forelimb used as a control region. AIE decreased baseline resting-state connectivity between PFC subregions (PrL-IL and IL-OFC) and between PFC-striatal regions (PrL-NAc, IL-CPu, IL-NAc, OFC-CPu, and OFC-NAc). Acute ethanol induced negative blood-oxygen-level-dependent changes within all regions of interest examined, along with significant increases in functional connectivity in control, but not AIE animals. Together, these data support the hypothesis that binge-like adolescent alcohol exposure causes persistent decreases in baseline frontolimbic (particularly frontostriatal) connectivity and alters sensitivity to acute ethanol-induced increases in functional connectivity in adulthood.
Parametry wytrzymałościowe łupka miedzionośnego
Creators: name: Bagiński, Lesław
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: łupek miedzionośny, wytrzymałość

description: Łupek miedzionośny III, Kowalczuk P.B., Drzymała J. (red.), WGGG PWr, Wrocław, ISBN 978-83-946706-0-3
Additional file 2 of Suicides by pesticide ingestion in Pakistan and the impact of pesticide regulation
Creators: name: Dabholkar, Shweta
name: Pirani, Shahina
name: Davis, Mark
name: Khan, Murad
name: Eddleston, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 2
Wpływ zawartości węgla organicznego na hydrofobowość łupka miedzionośnego
Creators: name: Kubiak, Bartosz
name: Drzymała, Jan
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: łupek miedzionośny, węgiel organiczny

description: Łupek miedzionośny III, Kowalczuk P.B., Drzymała J. (red.), WGGG PWr, Wrocław, ISBN 978-83-946706-0-3
Definitions of intradialytic hypotension
Creators: name: Assimon, Magdalene M.
name: Flythe, Jennifer E.
Publisher: name: Wiley
Year: 2017

description: Intradialytic hypotension (IDH) is a common and often distressful complication of hemodialysis. However, despite its clinical significance, there is no consensus, evidence-based medical definition for the condition. Over the years, numerous definitions have been implemented in both the clinical and research settings. Definition inconsistencies have hindered data synthesis and the development of evidence-based guidelines for the prevention and treatment of IDH, as well as prevented accurate estimation of the population burden of IDH and patient risk assessment. Most existing IDH definitions are comprised of one or more of the following components: (1) intradialytic BP criteria (requisite BP declines or minimum BP thresholds), (2) the provision of interventions aimed at restoring effective arterial volume, and/or (3) patient-reported symptoms. Remarkably, there are insufficient data to inform IDH definition construction, and it remains unknown if a single, universal definition can adequately capture the condition across patient subgroups, and in clinical and research settings.
Plural Number Words In The Alor-Pantar Languages
Creators: name: Klamer, Marian
name: Schapper, Antoinette
name: Corbett, Greville
Publisher: name: Zenodo
Year: 2017

description: In this chapter, we investigate the variation in form, syntax and semantics of the plural words found across the Alor-Pantar languages. We study five AP languages: Western Pantar, Teiwa, Abui, Kamang and Wersing. We show that plural words in Alor-Pantar family are diachronically instable: although proto-Alor-Pantar had a plural number word *non, many AP languages have innovated new plural words. Plural words in these languages exhibit not only a wide variety of different syntactic properties but also variable semantics, thus likening them more to the range exhibited by affixal plural number than previously recognized.
Additional file 3 of Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis
Creators: name: Chen, Han
name: Zhou, Xiaoying
name: Hu, Jingwen
name: Li, Shuo
name: Wang, Zi
name: Zhu, Tong
name: Cheng, Hong
name: Zhang, Guoxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Fig. S1. Forest plot visualizing the causal effects of lipid-associated traits with human lifespan. The Forest plot presented the MR estimates of circulating lipids on human lifespans in the discovery (the left plot) and validation (the right plot) datasets. Beta estimates and 95%CI were utilized to evaluate human lifespan in the discovery data, while in the validation dataset, Odds Ratio and 95%CI were used to estimate the 90th human longevity. As we used multiple GWAS databases from large consortia, the association estimates of the same trait were combined using a meta-analysis of the fixed or random effects model based on the heterogeneity. Abbreviations: OR: Odds Ratio; BMI, Body mass index; WHR, Waist-to-hip ratio; FBG, Fasting blood glucose;FI, Fasting Insulin; HOMO-IR, Homeostatic model assessment of insulin resistance.
Chancen Der Beruflichen Integration: Ein Beitrag Der Sozialarbeiterischen Beratung Zur Förderung Der Arbeitsintegration Von Vorläufig Aufgenommenen Asylsuchenden Und Anerkannten Flüchtlingen
Creators: name: Nguyen, Tan Vy
Publisher: name: Zenodo
Year: 2012
Subjects: subject: gnd:4055676-1
subject: gnd:4077570-7
subject: gnd:4120730-0

description: Die Integration von Migrantinnen und Migranten ist ein brennendes Thema der Schweiz und beschäftigt Akteure der Politik, der öffentlichen Verwaltung und der Zivilgesellschaft. Ein wichtiger Teil der Integrationspolitik ist die berufliche Integration. Voraussetzung für Erwerbsarbeit ist jedoch die Beherrschung der deutschen Sprache. Mit Sprachförderung ist oft ein Basis-Sprachkurs gemeint, der für eine nachhaltige Arbeitsintegration jedoch nicht ausreicht. Arbeitserfahrungen und Bildung aus dem Herkunftsland werden meist nur teilweise oder gar nicht anerkannt. Die Anerkennung oder Teilanerkennung könnte eine rasche Integration fördern. Viele Asylsuchende und Flüchtlinge sind als Hilfsarbeitende tätig und genau diese Arbeitsstellen für niedrig qualifizierte Arbeitnehmende werden in Schwellenländer ausgelagert. Die vorliegende Literaturarbeit befasst sich mit den rechtlichen und sozioökonomischen Rahmenbedingungen vorläufig aufgenommener Asylsuchender und anerkannter Flüchtlinge und bringt diese mit theoretischen Ansätzen zu Migration und Arbeitsintegration (Penninx, Bourdieu, Staub-Bernasconi und andere) in Verbindung. Aus den neu gewonnenen Erkenntnissen werden Handlungsansätze für die Sozialarbeit erarbeitet. Die Soziale Arbeit hat grosse Anstrengungen unternommen, um niedrig qualifizierte ausländische Arbeitsuchende durch Triagestellen (Stiftung Chance) oder durch Arbeitsintegrationsprogramme (AOZ) für den ersten Stellenmarkt fitzumachen. Diese Bachelor-Arbeit soll den Akteurinnen und Akteuren in diesem Problemfeld Impulse für ihre tägliche Arbeit geben.
description: + Code Diss LU: hslusa basa 2012 + Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2012
Treatment of premenstrual dysphoria with continuous versus intermittent dosing of oral contraceptives: Results of a three-arm randomized controlled trial
Creators: name: Girdler, Susan S.
name: Johnson, Jacqueline L.
name: Rubinow, David R.
name: Schmidt, Peter J.
name: Eisenlohr-Moul, Tory A.
Publisher: name: Hindawi
Year: 2017

description: BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomized controlled trials (RCTs) indicate that oral contraceptives administered with a shortened or eliminated hormone-free interval are superior to placebo. However, results of such trials are mixed, and no existing studies have directly compared continuous and intermittent dosing schedules of the same oral contraceptive. The present study compared placebo, intermittent dosing of oral contraceptives, and continuous dosing of contraceptives for the treatment of PMD. METHODS: Fifty-five women with prospectively confirmed PMD completed a three-arm, RCT in which they were randomized to 3 months of placebo (n = 22), intermittent drospirenone/ethinyl estradiol dosed on a 21-7 schedule (n = 17), or continuous drospirenone/estradiol (n = 16) following a baseline assessment month. RESULTS: All three groups demonstrated similar, robust reductions in premenstrual symptoms over time. A marked placebo response was observed. CONCLUSIONS: The study fails to replicate a uniquely beneficial effect of continuous COC on PMD. Additional work is needed to understand the psychosocial context bolstering the placebo response in women with PMD.
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum
Creators: name: Ma, Rui
name: Melo-Filho, Cleber C.
name: Gomes, Marcelo N.
name: Freitas-Junior, Lucio H.
name: Andrade, Carolina Horta
name: Muratov, Eugene
name: Moraes, Carolina B.
name: Franzblau, Scott G.
name: Neves, Bruno J.
name: Alcantara, Laura M.
Publisher: name: Elsevier
Year: 2017

description: Leishmaniasis are infectious diseases caused by parasites of genus Leishmania that affect affects 12 million people in 98 countries mainly in Africa, Asia, and Latin America. Effective treatments for this disease are urgently needed. In this study, we present a computer-aided approach to investigate a set of 32 recently synthesized chalcone and chalcone-like compounds to act as antileishmanial agents. As a result, nine most promising compounds and three potentially inactive compounds were experimentally evaluated against Leishmania infantum amastigotes and mammalian cells. Four compounds exhibited EC50 in the range of 6.2-10.98μM. In addition, two compounds, LabMol-65 and LabMol-73, exhibited cytotoxicity in macrophages >50μM that resulted in better selectivity compared to standard drug amphotericin B. These two compounds also demonstrated low cytotoxicity and high selectivity towards Vero cells. The results of target fishing followed by homology modeling and docking studies suggest that these chalcone compounds could act in Leishmania because of their interaction with cysteine proteases, such as procathepsin L. Finally, we have provided structural recommendations for designing new antileishmanial chalcones.
Emotion-related impulsivity and rumination predict the perimenstrual severity and trajectory of symptoms in women with a menstrually related mood disorder
Creators: name: Dawson, Danyelle N.
name: Paulson, Julia L.
name: Rubinow, David R.
name: Girdler, Susan S.
name: Peters, Jessica R.
name: Eisenlohr-Moul, Tory A.
Publisher: name: Wiley
Year: 2017

description: OBJECTIVE: Women with menstrually related mood disorders (MRMDs) demonstrate clinically significant distress during the premenstrual week that remits with the onset of menses. Relatively little is known about psychosocial mechanisms of MRMDs. Given the core affective and behavioral symptoms of MRMDs, dysfunctional responses to emotion (e.g., difficulties with awareness and regulation of emotion; rumination and impulsive or maladaptive behavior in response to emotion) may be important factors to explore as cognitive and behavioral mechanisms in MRMDs. The purpose of the present study was to examine the associations of various dysfunctional responses to emotion (as measured using the Difficulties in Emotion Regulation Scale [DERS] and brooding on the Ruminative Responses Scale [RRS]) with premenstrual symptom severity and trajectory. METHOD: A total of 54 women (mean age = 38.11; 65% Caucasian) with prospectively confirmed MRMDs completed the DERS and RRS, and provided 2-4 menstrual cycles of daily symptom reports. RESULTS: Only the emotion-related impulsivity subscale of the DERS was robustly associated with premenstrual symptom severity. Brooding rumination predicted a more rapid premenstrual increase and slower postmenstrual remission of some symptoms. CONCLUSION: Both rumination and emotion-related impulsivity may be important treatment targets in cognitive behavioral interventions aimed at reducing symptom severity and cyclicity in MRMDs.
65928: Letter: To Edward Marsh
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Discusses material to be included in Edward Marsh's 'Georgian Poetry' of 1916-1917 and what should be included in another anthology / asks what Marsh thinks about asking Harold Munro to allow for reprints of poems from 'Over the Brazier' in other volumes.
Interactive Effects of Ovarian Steroid Hormones on Alcohol Use and Binge Drinking Across the Menstrual Cycle
Creators: name: Roberts, Bethan
name: Eisenlohr-Moul, Tory
name: Martel, Michelle M.
Publisher: name: American Psychological Association (APA)
Year: 2017

description: Patterns and features of substance use and abuse vary across the menstrual cycle in humans. Yet, little work has systematically examined the within-person relationships between ovarian hormone changes and alcohol use across the menstrual cycle. Our study was the first to examine the roles of within-person levels of estradiol (E2) and progesterone (P4) in relation to daily alcohol use and binge drinking in young women. Participants were 22 naturally cycling women, ages 18-22, recruited through a university subject pool who reported any alcohol use and who completed a screening visit assessing study eligibility, followed by 35 subsequent days of data collection. E2 and P4 were obtained via enzyme immunoassay of saliva samples collected by participants each morning, 30 min after waking. Presence and degree of daily substance use were obtained using an adaptation of the Timeline FollowBack Interview completed daily. Results indicated that elevated E2 in the context of decreased P4 levels were associated with higher risk of drinking and binge drinking. These effects were present only on weekend days. Results are suggestive of a dual risk model in which both ovulatory E2 increases and perimenstrual P4 decreases increase risk for drinking. Differential associations of steroids with drinking across the menstrual cycle may suggest the need for clinical assessment of substance use to take into account hormone dynamics and menstrual cycle phase.
Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders
Creators: name: Dichter, Gabriel S.
name: Markiewitz, Nathan D.
name: Treadway, Michael T.
name: Greene, Rachel K.
name: Shah, Jasmine S.
name: Damiano-Goodwin, Cara R.
name: Mosner, Maya G.
name: McWeeny, Sean
name: Rutherford, Helena J. V.
name: Kinard, Jessica L.
name: Burchinal, Margaret R.
Publisher: name: Springer Nature
Year: 2017

description: This study investigated vicarious effort-based decision-making in 50 adolescents with autism spectrum disorders (ASD) compared to 32 controls using the Effort Expenditure for Rewards Task. Participants made choices to win money for themselves or for another person. When choosing for themselves, the ASD group exhibited relatively similar patterns of effort-based decision-making across reward parameters. However, when choosing for another person, the ASD group demonstrated relatively decreased sensitivity to reward magnitude, particularly in the high magnitude condition. Finally, patterns of responding in the ASD group were related to individual differences in consummatory pleasure capacity. These findings indicate atypical vicarious effort-based decision-making in ASD and more broadly add to the growing body of literature addressing social reward processing deficits in ASD.
66086: Ladies of Charity
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Manuscript in pen in Marion Scott's hand. Part of the 'Hospital Pictures' series. After manuscript drafts in the black manuscript notebook 52.1, in which the poem is titled 'Nurses', and a draft sent in an envelope dated 17th November 1917 to Scott. Possibly written while Ivor Gurney was on a signalling course at Seaton Delaval, Northumberland. Included in 'War's Embers' (1919).
Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase
Creators: name: Priestman, Melanie A.
name: Capuzzi, Stephen J.
name: Hughes, Robert M.
name: Herring, Laura E.
name: Lawrence, David S.
name: O'Banion, Colin P.
Publisher: name: Elsevier
Year: 2017

description: Although the cAMP-dependent protein kinase (PKA) is ubiquitously expressed, it is sequestered at specific subcellular locations throughout the cell, thereby resulting in compartmentalized cellular signaling that triggers site-specific behavioral phenotypes. We developed a three-step engineering strategy to construct an optogenetic PKA (optoPKA) and demonstrated that, upon illumination, optoPKA migrates to specified intracellular sites. Furthermore, we designed intracellular spatially segregated reporters of PKA activity and confirmed that optoPKA phosphorylates these reporters in a light-dependent fashion. Finally, proteomics experiments reveal that light activation of optoPKA results in the phosphorylation of known endogenous PKA substrates as well as potential novel substrates.
60862: Two photographs of Eric and Allan Jackson 1918
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: These two photographs were taken on July 28 1918 in Leyland Lancashire. They show my father Allan Jackson and his older brother Eric in their sailor suits. There was a saying at the time "Don't pay too much for the whistle", i.e. buy a quality suit and don't get distracted by the incidental details. Eric has HMS Lion on the band of his hat. My father and Eric were both born in Johannesburg where their father Harry Jackson was working with the Leyland Paint and Varnish Company. The children and my grandmother were sent back to England shortly after the outbreak of the War and my grandfather joined the Transvaal Scottish Regiment. Private No: 1974, 4th Regiment South African Infantry (South African Scottish) Transvaal Scottish. He died of Spanish Flu in barracks in Woking in October 1918, along with his brother Will who was in the same regiment. They died within a few days of each other. (I have posted a picture of Harry Bowman Jackson previously)
My grandmother was fortunate that her husband had joined a South African regiment rather than a British one as the war widow's benefits and penion were marginally higher than for British Army widows. My father's sister Joan was born after my gandfather died.

Editor's Comment:

Pte. Harry Bowman Jackson is buried in Leyland (St. Andrew) Churchyard.
His brother, Pte. 22128 William Jackson, 4th Regt. South African Infantry, died 24th October 1918, and is also buried in St. Andrew's Churchyard.
Additional file 1 of Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis
Creators: name: Chen, Han
name: Zhou, Xiaoying
name: Hu, Jingwen
name: Li, Shuo
name: Wang, Zi
name: Zhu, Tong
name: Cheng, Hong
name: Zhang, Guoxin
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. The STROBE statement guideline checklist of this study.
Additional file 1 of iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers
Creators: name: Arora, Pooja
name: Periwal, Neha
name: Goyal, Yash
name: Sood, Vikas
name: Kaur, Baljeet
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. List of descriptors with a brief description and number of features computed using Pfeature algorithm.
Estimation of cis-eQTL Effect Sizes Using a Log of Linear Model
Creators: name: Shabalin, Andrey
name: Nobel, Andrew B.
name: Palowitch, John
name: Wright, Fred A.
name: Zhou, Yi-Hui
Publisher: name: Oxford University Press (OUP)
Year: 2017

description: The study of expression Quantitative Trait Loci (eQTL) is an important problem in genomics and biomedicine. While detection (testing) of eQTL associations has been widely studied, less work has been devoted to the estimation of eQTL effect size. To reduce false positives, detection methods frequently rely on linear modeling of rank-based normalized or log-transformed gene expression data. Unfortunately, these approaches do not correspond to the simplest model of eQTL action, and thus yield estimates of eQTL association that can be uninterpretable and inaccurate. In this article, we propose a new, log-of-linear model for eQTL action, termed ACME, that captures allelic contributions to cis-acting eQTLs in an additive fashion, yielding effect size estimates that correspond to a biologically coherent model of cis-eQTLs. We describe a non-linear least-squares algorithm to fit the model by maximum likelihood, and obtain corresponding p-values. We perform careful investigation of the model using a combination of simulated data and data from the Genotype Tissue Expression (GTEx) project. Our results reveal little evidence for dominance effects, a parsimonious result that accords with a simple biological model for allele-specific expression and supports use of the ACME model. We show that Type-I error is well-controlled under our approach in a realistic setting, so that rank-based normalizations are unnecessary. Furthermore, we show that such normalizations can be detrimental to power and estimation accuracy under the proposed model. We then show, through effect size analyses of whole-genome cis-eQTLs in the GTEx data, that using standard normalizations instead of ACME noticeably affects the ranking and sign of estimates.
57756: Letter: To Marion Scott.
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Envelope containing letter.
Informs Marion Scott that things are starting to 'move' in their sector, and that Ivor Gurney may not have time to write again soon / requests changes to various versions of 'Requiem' and 'Acquiescence' / thanks Scott for a recent parcel / discusses the repercussions of the German retreat / 'Blighty' thoughts / Walt Whitman / being in the mood for Beethoven's 'Symphony Pathetique'.
Reproductive steroids and ADHD symptoms across the menstrual cycle
Creators: name: Martel, Michelle M.
name: Eisenlohr-Moul, Tory
name: Roberts, Bethan
Publisher: name: Elsevier
Year: 2017

description: Although Attention-Deficit/Hyperactivity Disorder shows (ADHD) male predominance, females are significantly impaired and exhibit additional comorbid disorders during adolescence. However, no empirical work has examined the influence of cyclical fluctuating steroids on ADHD symptoms in women. The present study examined estradiol (E2), progesterone (P4), and testosterone (T) associations with ADHD symptoms across the menstrual cycle in regularly-cycling young women (N=32), examining trait impulsivity as a moderator. Women completed a baseline measure of trait impulsivity, provided saliva samples each morning, and completed an ADHD symptom checklist every evening for 35days. Results indicated decreased levels of E2 in the context of increased levels of either P4 or T was associated with higher ADHD symptoms on the following day, particularly for those with high trait impulsivity. Phase analyses suggested both an early follicular and early luteal, or post-ovulatory, increase in ADHD symptoms. Therefore, ADHD symptoms may change across the menstrual cycle in response to endogenous steroid changes.
sj-pdf-3-epb-10.1177_23998083221075635 – Supplemental Material for Urban form planning and tsunami risk vulnerability: Analysis of 12 Chilean coastal cities
Creators: name: Vicuña, Magdalena
name: León, Jorge
name: Guzmán, Simón
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Geography
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental Material, sj-pdf-3-epb-10.1177_23998083221075635 for Urban form planning and tsunami risk vulnerability: Analysis of 12 Chilean coastal cities by Magdalena Vicuña, Jorge León and Simón Guzmán in Environment and Planning B: Urban Analytics and City Science
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Creators: name: Gallinger, Steven
name: Dodd, Anna
name: Moura, Shari
name: Liang, Sheng-Ben
name: Krzyzanowski, Paul M.
name: Albaba, Hamzeh
name: Southwood, Bernadette
name: Lemire, Mathieu
name: Wilson, Julie M.
name: Mbabaali, Faridah
name: Jang, Gun-Ho
name: Chadwick, Dianne
name: Bartlett, John M.S.
name: Knox, Jennifer J.
name: Ghai, Sangeet
name: Yeh, Jen Jen
name: Creighton, Sean
name: Miller, Jessica K.
name: Zhang, Amy
name: Moffitt, Richard A.
name: Hedley, David
name: Pasternack, Danielle
name: Fischer, Sandra E.
name: Notta, Faiyaz
name: Moore, Malcolm J.
name: Aung, Kyaw L.
name: O'Kane, Grainne M.
name: Lungu, Ilinca M.
name: Holter, Spring
name: Grant, Robert C.
name: Dhani, Neesha
name: Denroche, Robert E.
name: Timms, Lee
name: Connor, Ashton A.
Publisher: name: American Association for Cancer Research (AACR)
Year: 2018

description: Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational and transcriptional features for better treatment selection.Experimental Design: Patients with advanced PDAC were prospectively recruited prior to first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided percutaneous core biopsy for WGS and RNASeq. Laser capture microdissection was performed for all cases. Primary endpoint was feasibility to report WGS results prior to first disease assessment CT scan at 8 weeks. The main secondary endpoint was discovery of patient subsets with predictive mutational and transcriptional signatures.Results: Sixty-three patients underwent a tumor biopsy between December 2015 and June 2017. WGS and RNASeq were successful in 62 (98%) and 60 (95%), respectively. Genomic results were reported at a median of 35 days (range, 19-52 days) from biopsy, meeting the primary feasibility endpoint. Objective responses to first-line chemotherapy were significantly better in patients with the classical PDAC RNA subtype compared with those with the basal-like subtype (P = 0.004). The best progression-free survival was observed in those with classical subtype treated with m-FOLFIRINOX. GATA6 expression in tumor measured by RNA in situ hybridization was found to be a robust surrogate biomarker for differentiating classical and basal-like PDAC subtypes. Potentially actionable genetic alterations were found in 30% of patients.Conclusions: Prospective genomic profiling of advanced PDAC is feasible, and our early data indicate that chemotherapy response differs among patients with different genomic/transcriptomic subtypes
60863: Letter sent home by Herbert Freestone
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Herbert Edward Freestone, born 29th February 1880 at Hadfield, Derbyshire. He was a private soldier in the Royal Welsh Fusiliers.
Herbert Freestone was invalided out before the end of the war and lived until 1956. The daughter to whom the letter was sent was my mother, Dorothy May Freestone.

Editor's Comment:

On headed notepaper: 'R.W.F.' (Royal Welsh Fusiliers), below dragon.
Darwin: An Excellent Environment To Probe Neutrino Physics
Creators: name: SANCHEZ-LUCAS, Patricia
Publisher: name: Zenodo
Year: 2018

description: The future of dark matter direct searches calls for the use of multi-ton scale detectors. In this context, DARWIN (DARk matter WImp search with liquid xenoN), with its 40 tons of active target, will be the ultimate detector, able to explore the entire experimentally accessible parameter space for WIMPs. Such a huge detector, with its low-energy threshold and ultra low background level, will be also a powerful tool to probe neutrino physics. We show that solar neutrinos (pp) will be seen with a precision below 2%, allowing to test neutrino models at very low energies. A competitive half-life sensitivity is at reach for the neutrinoless double beta decay of 136
^{136}
Xe. The coherent neutrino-nucleus interaction will be observed as well. The event rate of this process has been estimated for different neutrino sources, including solar neutrinos and neutrinos from supernova explosions.
Additional file 3 of iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers
Creators: name: Arora, Pooja
name: Periwal, Neha
name: Goyal, Yash
name: Sood, Vikas
name: Kaur, Baljeet
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 3: Table S2. Performance metrics of seven machine learning models for prediction of IL-13 inducing peptides on the top10 to top 95 features via mRMR (iIL13Pred) and its comparison with the state of the art (IL13Pred). The higher values are highlighted in bold.
A bibliometric review of drug repurposing
Creators: name: Williams, Antony J.
name: Tropsha, Alexander
name: Ekins, Sean
name: Baker, Nancy C.
Publisher: name: Elsevier
Year: 2018

description: We have conducted a bibliometric review of drug repurposing by scanning >25 million papers in PubMed and using text-mining methods to gather, count and analyze chemical-disease therapeutic relationships. We find that >60% of the ~35,000 drugs or drug candidates identified in our study have been tried in more than one disease, including 189 drugs that have been tried in >300 diseases each. Whereas in the majority of cases these drugs were applied in therapeutic areas close to their original use, there have been striking, and perhaps instructive, successful attempts of drug repurposing for unexpected, novel therapeutic areas.
Additional file 4 of Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis
Creators: name: Chen, Han
name: Zhou, Xiaoying
name: Hu, Jingwen
name: Li, Shuo
name: Wang, Zi
name: Zhu, Tong
name: Cheng, Hong
name: Zhang, Guoxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Fig. S2. Triangular linkage disequilibrium (LD) matrix plot of SNP markers of each lipid-lowering drug target gene. The plots were produced using pairwise r2 estimates of LD using the LD LDmatrix Tool ( https://ldlink.nih.gov/ ). The pairwise r2 values are given inside the boxes. Combinations with significant LD between the same types of gene alleles were marked with *. *, **, *** stands for p-value < 0.01, 0.005 and 0.001, respectively.