cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis, structure–affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: Structural factors contributing to selectivity
Creators: name: Mosier, Philip D.
name: Westkaemper, Richard B.
name: Shah, Jitesh R.
name: Roth, Bryan L.
name: Kellogg, Glen E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Histamine H1 and serotonin 5-HT2A receptors present in the CNS have been implicated in various neuropsychiatric disorders. 9-Aminomethyl-9,10-dihydroanthracene (AMDA), a conformationally constrained diarylalkyl amine derivative, has affinity for both of these receptors. A structure-affinity relationship (SAFIR) study was carried out studying the effects of N-methylation, varying the linker chain length and constraint of the aromatic rings on the binding affinities of the compounds with the 5-HT2A and H1 receptors. Homology modeling of the 5-HT2A and H1 receptors suggests that AMDA and its analogs, the parent of which is a 5-HT2A antagonist, can bind in a fashion analogous to that of classical H1 antagonists whose ring systems are oriented towards the fifth and sixth transmembrane helices. The modeled orientation of the ligands are consistent with the reported site-directed mutagenesis data for 5-HT2A and H1 receptors and provide a potential explanation for the selectivity of ligands acting at both receptors.
Molecular phonons and their absorption/emission spectra from the far IR to microwaves
Creators: name: Papoular, Renaud
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Together with their fingerprint modes, molecules carry coherent vibrations of all their atoms (phonons). Phonon spectra extend from $\sim$20 to more than $10^{4}\,μ$m, depending on molecular size. These spectra are discrete but large assemblies of molecules of the same family, differing only by minor structural details, will produce continua. As such assemblies are expected to exist in regions where dust accumulates, they are bound to contribute to the observed continua underlying the Unidentified Infrared Bands and the 21-mum band of planetary nebulae as well as to the diffuse galactic emission surveyed by the Planck astronomical satellite and other means. The purpose of this work is to determine, for carbon-rich molecules, the intensity of such continua and their extent into the millimetric range, and to evaluate their detectability in this range. The rules governing the spectral distributions of phonons are derived and shown to differ from those which obtain in the solid state. Their application allow the extinction cross-section per H atom, and its maximum wavelength, to be determined as a function of molecular size and dimensionality. Chemical modeling of more than 15 large molecules illustrate these results. It is found that the maximum phonon wavelength of a 2D structure increases roughly as the square of its larger dimension. Spectral energy distributions were computed as far as 4000 mum, for molecules up to 50 A° in length.
description: 13 p, 14 figures, accepted by MNRAS
Optimal design-for-control of self-cleaning water distribution networks using a convex multi-start algorithm
Creators: name: Jenks, Bradley
name: Pecci, Filippo
name: Stoianov, Ivan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: The provision of self-cleaning velocities has been shown to reduce the risk of discolouration in water distribution networks (WDNs). Despite these findings, control implementations continue to be focused primarily on pressure and leakage management. This paper considers the control of diurnal flow velocities to maximize the self-cleaning capacity (SCC) of WDNs. We formulate a new optimal design-for-control problem where locations and operational settings of pressure control and automatic flushing valves are jointly optimized. The problem formulation includes a nonconvex objective function, nonconvex hydraulic conservation law constraints, and binary variables for modelling valve placement, resulting in a nonconvex mixed integer nonlinear programming (MINLP) optimization problem. Considering the challenges with solving nonconvex MINLP problems, we propose a heuristic algorithm which combines convex relaxations (with domain reduction), a randomization technique, and a multi-start strategy to compute feasible solutions. We evaluate the proposed algorithm on case study networks with varying size and degrees of complexity, including a large-scale operational network in the UK. The convex multi-start algorithm is shown to be a more robust solution method compared to an off-the-shelf genetic algorithm, finding good-quality feasible solutions to all design-for-control numerical experiments. Moreover, we demonstrate the implemented multi-start strategy to be a fast and scalable method for computing feasible solutions to the nonlinear SCC control problem. The proposed method extends the control capabilities and benefits of dynamically adaptive networks to improve water quality in WDNs.
Secure Data Offloading Strategy for Connected and Autonomous Vehicles
Creators: name: Tassi, Andrea
name: Mavromatis, Ioannis
name: Piechocki, Robert J.
name: Nix, Andrew
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Connected and Automated Vehicles (CAVs) are expected to constantly interact with a network of processing nodes installed in secure cabinets located at the side of the road -- thus, forming Fog Computing-based infrastructure for Intelligent Transportation Systems (ITSs). Future city-scale ITS services will heavily rely upon the sensor data regularly off-loaded by each CAV on the Fog Computing network. Due to the broadcast nature of the medium, CAVs' communications can be vulnerable to eavesdropping. This paper proposes a novel data offloading approach where the Random Linear Network Coding (RLNC) principle is used to ensure the probability of an eavesdropper to recover relevant portions of sensor data is minimized. Our preliminary results confirm the effectiveness of our approach when operated in a large-scale ITS networks.
description: To appear in IEEE VTC-Spring 2019
Uncertainty Marginal Price, Transmission Reserve, and Day-ahead Market Clearing with Robust Unit Commitment
Creators: name: Ye, Hongxing
name: Ge, Yinyin
name: Shahidehpour, Mohammad
name: Li, Zuyi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The increasing penetration of renewable energy in recent years has led to more uncertainties in power systems. These uncertainties have to be accommodated by flexible re- sources (i.e. upward and downward generation reserves). In this paper, a novel concept, Uncertainty Marginal Price (UMP), is proposed to price both the uncertainty and reserve. At the same time, the energy is priced at Locational Marginal Price (LMP). A novel market clearing mechanism is proposed to credit the gener- ation and reserve and to charge the load and uncertainty within the Robust Unit Commitment (RUC) in the Day-ahead market. We derive the UMPs and LMPs in the robust optimization framework. UMP helps allocate the cost of generation reserves to uncertainty sources. We prove that the proposed market clearing mechanism leads to partial market equilibrium. We find that transmission reserves must be kept explicitly in addition to generation reserves for uncertainty accommodation. We prove that transmission reserves for ramping delivery may lead to Financial Transmission Right (FTR) underfunding in existing markets. The FTR underfunding can be covered by congestion fund collected from uncertainty payment in the proposed market clearing mechanism. Simulations on a six-bus system and the IEEE 118-bus system are performed to illustrate the new concepts and the market clearing mechanism.
description: to appear in IEEE Transactions on Power Systems, IEEE link: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7524711. arXiv admin note: text overlap with arXiv:1507.01167
(102925) Beryl Hermione Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Stellar halo striations from assumptions of axisymmetry
Creators: name: Davies, Elliot Y.
name: Dillamore, Adam M.
name: Belokurov, Vasily
name: Evans, N. Wyn
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Motivated by the LMC's impact on the integral of motion space of the stellar halo, we run an $N$-body merger simulation to produce a population of halo-like stars. We subsequently move to a test particle simulation, in which the LMC perturbs this debris. When an axisymmetric potential is assumed for the final snapshot of the $N$-body merger remnant, a series of vertical striations in $(L_z, E)$ space form as the LMC approaches its pericentre. These result from the formation of overdensities in angular momentum owing to a relationship between the precession rate of near radial orbits and the torquing of these orbits by the LMC. This effect is heavily dependent on the shape of the inner potential. If a quadrupole component of the potential is included these striations become significantly less apparent due to the difference in precession rate between the two potentials. The absence of these features in data, and the dramatic change in orbital plane precession rate, discourages the use of an axisymmetric potential for highly eccentric orbits accreted from a massive GSE-like merger. Given the link between appearance of these striations and the shape of the potential, this effect may provide a new method of constraining the axisymmetry of the halo.
description: 14 pages, 17 figures, submitted to MNRAS
Supplementary document for Weak non-line-of-sight target echoes extraction without accumulation - 6622164.pdf
Creators: name: Li, Tailin
name: Luo, Yihan
name: Zhao, Kaiyuan
name: Xia, Shiye
name: Liu, YaQing
name: Ma, Haotong
name: ge, ren
name: Xie, Zongliang
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: The supplement contains the SNR analysis of the dual-detector method, the detection probability and false-alarm probability and the simulation of the effectiveness of the dual-detector method for NLOS imaging.
Contributions to the nucleon form factors from bubble and tadpole diagrams
Creators: name: Gao, Z. Y.
name: Wang, P.
name: Yang, M. Y.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The nonlocal chiral effective theory is applied to investigate the electromagnetic and strange form factors of nucleon. The bubble and tadpole diagrams are included in the calculation. With the contributions from bubble and tadpole diagrams, the obtained electromagnetic form factors are close to the results without these contributions as long as the low energy constants $c_1$ and $c_2$ are properly chosen, while the magnitudes of strange form factors become larger. Both the electromagnetic and strange form factors are still in good agreement with the experimental data.
description: 11 pages,7 figures
Efficient Millimeter-Wave Infrastructure Placement for City-Scale ITS
Creators: name: Mavromatis, Ioannis
name: Tassi, Andrea
name: Piechocki, Robert J.
name: Nix, Andrew
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Millimeter Waves (mmWaves) will play a pivotal role in the next-generation of Intelligent Transportation Systems (ITSs). However, in deep urban environments, sensitivity to blockages creates the need for more sophisticated network planning. In this paper, we present an agile strategy for deploying road-side nodes in a dense city scenario. In our system model, we consider strict Quality-of-Service (QoS) constraints (e.g. high throughput, low latency) that are typical of ITS applications. Our approach is scalable, insofar that takes into account the unique road and building shapes of each city, performing well for both regular and irregular city layouts. It allows us not only to achieve the required QoS constraints but it also provides up to $50\%$ reduction in the number of nodes required, compared to existing deployment solutions.
description: To appear in IEEE VTC-Spring 2019
Additional file 2 of Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging
Creators: name: Patterson, Andrew J.
name: Sarode, Anuja
name: Sadeer Al-Kindi
name: Shaver, Lauren
name: Thomas, Rahul
name: Watson, Evelyn
name: Alaiti, Mohamad Amer
name: Yuchi Liu
name: Hamilton, Jessie
name: Seiberlich, Nicole
name: Rashid, Imran
name: Gilkeson, Robert
name: Schilz, Robert
name: Hoit, Brian
name: Jenkins, Trevor
name: Zullo, Melissa
name: Bossone, Eduardo
name: Longenecker, Christopher
name: Simonetti, Orlando
name: Rajagopalan, Sanjay
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 2: Figure S2 Bland Altman analysis of rest and stress average pulmonary artery velocity as assessed using real time velocity encoding sequence.
(102924) Herbert John Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Light projectile elastic scattering by nuclei described by the Gogny interaction
Creators: name: Moraña, J. López
name: Viñas, X.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this work, we study the elastic scattering of some light particles, such as $^2$H, $^3$H, $^3$He, and $^4$He, by heavy target nuclei with an extended Watanabe model, which uses as input the neutron-nucleus and proton-nucleus optical potentials and the ground-state wave functions of the projectile. The nucleon-nucleus optical potential used in this work was obtained within a semi-microscopic nuclear matter approach, whose real and imaginary parts are provided by the first and second-order terms, respectively, of the Taylor expansion of the Brueckner-Hartree-Fock mass operator obtained with the reaction G-matrix built up with the Gogny force \cite{lopez21}. The angular distributions of the scattering of $^2$H, $^3$H, $^3$He, and $^4$He from different target nuclei and at a different incident energy of the projectile computed with this model are analyzed. The reaction cross-sections corresponding to some of these scattering processes are also calculated. Our results are compared with the experimental values as well as with another Watanabe calculation where the nucleon-nucleus the optical potential is provided by the phenomenological Köning-Delaroche model. The limitations of the extended Watanabe model used in this work are also discussed.
(102923) Millicent Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Agile Data Offloading over Novel Fog Computing Infrastructure for CAVs
Creators: name: Tassi, Andrea
name: Mavromatis, Ioannis
name: Piechocki, Robert
name: Nix, Andrew
name: Compton, Christian
name: Poole, Tracey
name: Schuster, Wolfgang
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Future Connected and Automated Vehicles (CAVs) will be supervised by cloud-based systems overseeing the overall security and orchestrating traffic flows. Such systems rely on data collected from CAVs across the whole city operational area. This paper develops a Fog Computing-based infrastructure for future Intelligent Transportation Systems (ITSs) enabling an agile and reliable off-load of CAV data. Since CAVs are expected to generate large quantities of data, it is not feasible to assume data off-loading to be completed while a CAV is in the proximity of a single Road-Side Unit (RSU). CAVs are expected to be in the range of an RSU only for a limited amount of time, necessitating data reconciliation across different RSUs, if traditional approaches to data off-load were to be used. To this end, this paper proposes an agile Fog Computing infrastructure, which interconnects all the RSUs so that the data reconciliation is solved efficiently as a by-product of deploying the Random Linear Network Coding (RLNC) technique. Our numerical results confirm the feasibility of our solution and show its effectiveness when operated in a large-scale urban testbed.
description: To appear in IEEE VTC-Spring 2019
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure–activity relationships of novel dicamphanoyl-2′,2′-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents
Creators: name: Lee, Kuo Hsiung
name: Chen, Chin Ho
name: Shi, Qian
name: Huang, Li
name: Zhu, Hao
name: Ho, Phong
name: Zhou, Ting
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In a continued study, 23 3′R,4′R-di-O-(−)-camphanoyl-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives (5–27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR-1) strain, using 2-EDCP (4) and 2-MDCP (35) as controls. New DCP analogs 5, 9, 14, and 22 exhibited potent anti-HIV activity against HIVNL4-3 with EC50 and therapeutic index (TI) values ranging from 0.036 μM to 0.14 μM and from 110 to 420, respectively. Compounds 5 and 9 also exhibited good activity against RTMDR-1 (EC50 0.049 and 0.054 μM; TI 310 and 200, respectively), and were two-fold more potent than the leads 4 and 35 (EC50 0.11 and 0.19 μM; TI 60 and 58, respectively). Evaluation of water solubility showed that 5 and 22 were 5–10 times more water soluble than 4. Quantitative structure-activity relationship (QSAR) modeling results were first performed on this compound type, and the models should aid in design of future anti-HIV DCP analogs and potential clinical drug candidates.
Unimodality for free multiplicative convolution with free normal distributions on the unit circle
Creators: name: Hasebe, Takahiro
name: Ueda, Yuki
Publisher: name: arXiv
Year: 2019
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60E07, 46L54, 60J65, 60B15

description: We study unimodality for free multiplicative convolution with free normal distributions $\{λ_t\}_{t>0}$ on the unit circle. We give four results on unimodality for $μ\boxtimesλ_t$: (1) if $μ$ is a symmetric unimodal distribution on the unit circle then so is $μ\boxtimes λ_t$ at any time $t>0$; (2) if $μ$ is a symmetric distribution on $\mathbb{T}$ supported on $\{e^{iθ}: θ\in [-φ,φ]\}$ for some $φ\in (0,π/2)$, then $μ\boxtimes λ_t$ is unimodal for sufficiently large $t>0$; (3) ${\bf b} \boxtimes λ_t$ is not unimodal at any time $t>0$, where ${\bf b}$ is the equally weighted Bernoulli distribution on $\{1,-1\}$; (4) $λ_t$ is not freely strongly unimodal for sufficiently small $t>0$. Moreover, we study unimodality for classical multiplicative convolution (with Poisson kernels), which is useful in proving the above four results.
description: 19 pages, 4 figures
Grassmann tensor-network method for strong-coupling QCD
Creators: name: Bloch, Jacques
name: Lohmayer, Robert
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present a tensor-network method for strong-coupling QCD with staggered quarks at nonzero chemical potential. After integrating out the gauge fields at infinite coupling, the partition function can be written as a full contraction of a tensor network consisting of coupled local numeric and Grassmann tensors. To evaluate the partition function and to compute observables, we develop a Grassmann higher-order tensor renormalization group method, specifically tailored for this model. We apply the method to the two-dimensional case and validate it by comparing results for the partition function, the chiral condensate and the baryon density with exact analytical expressions on small lattices up to volumes of $4\times4$. For larger two-dimensional volumes, we present tensor results for the chiral condensate as a function of the mass and volume, and observe that the chiral symmetry is not broken dynamically in two dimensions. Furthermore, our results for the number density as a function of the chemical potential hint at a first-order phase transition. Finally, we present some preliminary tensor results for three-dimensional strong-coupling QCD.
description: 10 pages, 6 figures, proceedings of the 39th International Symposium on Lattice Field Theory, 8-13 August, 2022, Bonn
Additional file 3 of Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging
Creators: name: Patterson, Andrew J.
name: Sarode, Anuja
name: Sadeer Al-Kindi
name: Shaver, Lauren
name: Thomas, Rahul
name: Watson, Evelyn
name: Alaiti, Mohamad Amer
name: Yuchi Liu
name: Hamilton, Jessie
name: Seiberlich, Nicole
name: Rashid, Imran
name: Gilkeson, Robert
name: Schilz, Robert
name: Hoit, Brian
name: Jenkins, Trevor
name: Zullo, Melissa
name: Bossone, Eduardo
name: Longenecker, Christopher
name: Simonetti, Orlando
name: Rajagopalan, Sanjay
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 3 Table S1 Pearson Correlation Coefficients
Anti-AIDS agents 82: Synthesis of seco-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents
Creators: name: Xia, Yi
name: Yu, Donglei
name: Yang, Zheng Yu
name: Chen, Chin Ho
name: Zhang, Bei Na
name: Tang, Jian
name: Chen, Ying
name: Morris-Natschke, Susan L.
name: Xia, Peng
name: Qian, Keduo
name: Lee, Kuo Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Thirteen novel seco-DCK analogs (4–16) with several new skeletons were designed, synthesized and screened for in vitro anti-HIV-1 activity. Among them, three compounds (5, 13, and 16) showed moderate activity, and compound 9 exhibited the best activity with an EC50 value of 0.058 μM and a therapeutic index (TI) of 1000. The activity of 9 was better than that of 4-methyl DCK (2, EC50: 0.126 μM, TI: 301.2) in the same assay. Additionally, 9 also showed antiviral activity against a multi-RT inhibitor-resistant strain (RTMDR), which is insensitive to most DCK analogs. Compared with 2, compound 9 has a less complex structure, fewer hydrogen-bond acceptors, and a reduced log P value. Therefore, it is likely to exhibit better ADME, and appears to be a promising new lead for further development as an anti-HIV candidate.
Measurement of Angular Asymmetries in the Decays B->K*l+l-
Creators: name: Babar Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study the lepton forward-backward asymmetry AFB and the longitudinal K* polarization FL, as well as an observable P2 derived from them, in the rare decays B->K*l+l-, where l+l- is either e+e- or mu+mu-, using the full sample of 471 million BBbar events collected at the Upsilon(4S) resonance with the Babar detector at the PEP-II e+e- collider. We separately fit and report results for the B+->K*+l+l- and B0->K*0l+l- final states, as well as their combination B->K*l+l-, in five disjoint dilepton mass-squared bins. An angular analysis of B+->K*+l+l- decays is presented here for the first time.
description: 19 pages, 9 figures, submitted to PRD
Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2′-monomethyl-4-methyl- and 1′-thia-4-methyl-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs☆
Creators: name: Xia, Yi
name: Xia, Peng
name: Lee, Kuo Hsiung
name: Xu, Shi Qing
name: Qian, Keduo
name: Morris-Natschke, Susan L.
name: Yang, Zheng Yu
name: Yu, Donglei
name: Chen, Ying
name: Yan, Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In a continuing investigation into the pharmacophores and structure-activity relationship (SAR) of (3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) as a potent anti-HIV agent, 2′-monomethyl substituted 1′-oxa, 1′-thia, 1′-sulfoxide and 1′-sulfone analogs were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Among them, 2′S-monomethyl-4-methyl DCK (5a) and 2′S-monomethyl-1′-thia-4-methyl DCK (7a) exhibited potent anti-HIV activity with EC50 values of 40.2 and 39.1 nM and remarkable therapeutic indexes of 705 and 1000, respectively, which were better than those of the lead compound DCK in the same assay. In contrast, the corresponding isomeric 2′R-monomethyl-4-methyl DCK (6) and 2′R-monomethyl-1′-thia-4-methyl DCK (8) showed much weaker inhibitory activity against HIV-1 replication. Therefore, the bioassay results suggest that the spatial orientation of the 2′-methyl group in DCK analogs can have important effects on anti-HIV activity of this compound class.
A Dataset of Full-Stack ITS-G5 DSRC Communications over Licensed and Unlicensed Bands Using a Large-Scale Urban Testbed
Creators: name: Tassi, Andrea
name: Mavromatis, Ioannis
name: Piechocki, Robert J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: A dataset of measurements of ETSI ITS-G5 Dedicated Short Range Communications (DSRC) is presented. Our dataset consists of network interactions happening between two On-Board Units (OBUs) and four Road Side Units (RSUs). Each OBU was fitted onto a vehicle driven across the FLOURISH Test Track in Bristol, UK. Each RSU and OBU was equipped with two transceivers operating at different frequencies. During our experiments, each transceiver broadcasts Cooperative Awareness Messages (CAMs) over the licensed DSRC band, and over the unlicensed Industrial, Scientific, and Medical radio (ISM) bands 2.4GHz-2.5GHz and 5.725GHz-5.875GHz. Each transmitted and received CAM is logged along with its Received Signal Strength Indicator (RSSI) value and accurate positioning information. The Media Access Control layer (MAC) layer Packet Delivery Rates (PDRs) and RSSI values are also empirically calculated across the whole length of the track for any transceiver. The dataset can be used to derive realistic approximations of the PDR as a function of RSSI values under urban environments and for both the DSRC and ISM bands -- thus, the dataset is suitable to calibrate (simplified) physical layers of full-stack vehicular simulators where the MAC layer PDR is a direct function of the RSSI. The dataset is not intended to be used for signal propagation modelling. The dataset can be found at https://doi.org/10.5523/bris.eupowp7h3jl525yxhm3521f57 , and it has been analyzed in the following paper: I. Mavromatis, A. Tassi, and R. J. Piechocki, "Operating ITS-G5 DSRC over Unlicensed Bands: A City-Scale Performance Evaluation," IEEE PIMRC 2019. [Online]. Available: arXiv:1904.00464.
description: Manuscript submitted to Elsevier Data in Brief
Evidence of fresh cosmic ray in galactic plane based on DAMPE measurement of B/C and B/O ratios
Creators: name: Zhang, Pei-Pei
name: He, Xin-Yu
name: Liu, Wei
name: Guo, Yi-Qing
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: More and more experiments have identified that the energy spectra of both primary and secondary cosmic-rays exhibit a hardening above $\sim 200$ GV. Most recently, the DAMPE experiment has reported a hardening of boron-to-carbon ratio at $200$ GV. These signs call for modifications of the conventional cosmic-ray (CR) picture. In this work, we propose that the plethoric secondary cosmic rays, for example, boron, antiprotons, originate from the hadronic interactions of freshly accelerated cosmic rays with the interstellar gas near the sources. We find that secondary-to-primary ratios, for example, boron-to-carbon, boron-to-oxygen and antiproton-to-proton ratios, could be well described. The measurements of electrons and positrons could also be accounted for.
description: 13 pages, 4 figures, published in JCAP
Discovery of Seven Companions to Intermediate Mass Stars with Extreme Mass Ratios in the Scorpius-Centaurus Association
Creators: name: Hinkley, Sasha
name: Kraus, Adam L.
name: Ireland, Michael J.
name: Cheetham, Anthony
name: Carpenter, John M.
name: Tuthill, Peter
name: Lacour, Sylvestre
name: Evans, Thomas M.
name: Haubois, Xavier
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the detection of seven low mass companions to intermediate-mass stars (SpT B/A/F; $M$$\approx$1.5-4.5 solar masses) in the Scorpius-Centaurus Association using nonredundant aperture masking interferometry. Our newly detected objects have contrasts $ΔL'$$\approx$4-6, corresponding to masses as low as $\sim$20 Jupiter masses and mass ratios of $q$$\approx$0.01-0.08, depending on the assumed age of the target stars. With projected separations $ρ$$\approx$10-30 AU, our aperture masking detections sample an orbital region previously unprobed by conventional adaptive optics imaging of intermediate mass Scorpius-Centaurus stars covering much larger orbital radii ($\approx$30-3000 AU). At such orbital separations, these objects resemble higher mass versions of the directly imaged planetary mass companions to the 10-30 Myr, intermediate-mass stars HR 8799, $β$ Pictoris, and HD95086. These newly discovered companions span the brown dwarf desert, and their masses and orbital radii provide a new constraint on models of the formation of low-mass stellar and substellar companions to intermediate-mass stars.
description: Accepted for Publication in ApJ Letters
Operating ITS-G5 DSRC over Unlicensed Bands: A City-Scale Performance Evaluation
Creators: name: Mavromatis, Ioannis
name: Tassi, Andrea
name: Piechocki, Robert J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Future Connected and Autonomous Vehicles (CAVs) will be equipped with a large set of sensors. The large amount of generated sensor data is expected to be exchanged with other CAVs and the road-side infrastructure. Both in Europe and the US, Dedicated Short Range Communications (DSRC) systems, based on the IEEE 802.11p Physical Layer, are key enabler for the communication among vehicles. Given the expected market penetration of connected vehicles, the licensed band of 75 MHz, dedicated to DSRC communications, is expected to become increasingly congested. In this paper, we investigate the performance of a vehicular communication system, operated over the unlicensed bands 2.4 GHz - 2.5 GHz and 5.725 GHz - 5.875 GHz. Our experimental evaluation was carried out in a testing track in the centre of Bristol, UK and our system is a full-stack ETSI ITS-G5 implementation. Our performance investigation compares key communication metrics (e.g., packet delivery rate, received signal strength indicator) measured by operating our system over the licensed DSRC and the considered unlicensed bands. In particular, when operated over the 2.4 GHz - 2.5 GHz band, our system achieves comparable performance to the case when the DSRC band is used. On the other hand, as soon as the system, is operated over the 5.725 GHz - 5.875 GHz band, the packet delivery rate is 30% smaller compared to the case when the DSRC band is employed. These findings prove that operating our system over unlicensed ISM bands is a viable option. During our experimental evaluation, we recorded all the generated network interactions and the complete data set has been publicly available.
description: IEEE PIMRC 2019, to appear
(102922) Mabel Florence Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents
Creators: name: Bastow, Kenneth F.
name: Nakagawa-Goto, Kyoko
name: Wu, Pei Chi
name: Morris-Natschke, Susan L.
name: Dong, Yizhou
name: Hung, Mien Chie
name: Lee, Kuo Hsiung
name: Brossi, Arnold
name: Shi, Qian
name: Lang, Jing Yu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: 6-Phenyl-4H-furo[3,2-c]pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10-13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100- to 250-fold more potent against SK-BR-3 (ED50 0.28 and 0.44 μM, respectively) compared with other cancer cell lines tested. In addition, 25 displayed low cytotoxicity against normal breast cell lines 184A1 and MCF10A. Compounds 25 and 27 merit further investigation in our continuing program to generate and develop selective anti-breast cancer agents.
(102921) Lancelot Arthur Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Conjugates of betulin derivatives with AZT as potent anti-HIV agents
Creators: name: Chen, Chin Ho
name: Xiong, Juan
name: Takaishi, Yoshihisa
name: Qian, Keduo
name: Kashiwada, Yoshiki
name: Morris-Natschke, Susan L.
name: Lee, Kuo Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49–53, 55, 56, 59, 60) exhibited potent anti-HIV activity at the submicromolar level, with EC50 values ranging from 0.040 to 0.098 µM in HIV-1NL4-3 infected MT-4 cells. These compounds were equipotent or more potent than 3-O-(3',3'-dimethylsuccinyl)betulinic acid (2), which is currently in Phase IIb anti-AIDS clinical trial.
Magnetic braking during direct collapse black hole formation
Creators: name: Latif, Muhammad A.
name: Schleicher, Dominik R. G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Magnetic fields are expected to be efficiently amplified during the formation of the first massive black holes via the small-scale dynamo and in the presence of strong accretion shocks occurring during gravitational collapse. Here, we analyze high-resolution cosmological magneto-hydrodynamical simulations of gravitational collapse in atomic cooling halos, exploring the dynamical role of magnetic fields, particularly concerning the effect of magnetic braking and angular momentum transport. We find that after the initial amplification, magnetic fields contribute to the transport of angular momentum and reduce it compared to pure hydrodynamical simulations. However, the magnetic and Reynolds torques do not fully compensate for the inward advection of angular momentum, which still accumulates over timescales of $\sim1$~Myr. A Jeans analysis further shows that magnetic pressure strongly contributes to suppressing fragmentation on scales of $0.1-10$~pc. Overall, the presence of magnetic fields thus aids in the transport of angular momentum and favors the formation of massive objects.
description: Accepted for Publication in ApJL, comments are welcome
Supplementary document for Weak non-line-of-sight target echoes extraction without accumulation - 6644112.pdf
Creators: name: Li, Tailin
name: Luo, Yihan
name: Zhao, Kaiyuan
name: Xia, Shiye
name: Liu, YaQing
name: Ma, Haotong
name: ge, ren
name: Xie, Zongliang
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: This supplement performs a simulation to test the effectiveness; analyze the detection probability and false-alarm probability; and test effectiveness of the dual-detector method for NLOS imaging.
A Revisit to High Thermoelectric Performance of Single-layer MoS2
Creators: name: Jin, Zelin
name: Liao, Quanwen
name: Fang, Haisheng
name: Liu, Zhichun
name: Liu, Wei
name: Ding, Zhidong
name: Luo, Tengfei
name: Yang, Nuo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Both electron and phonon transport properties of single layer MoS2 (SLMoS2) are studied. Based on first-principles calculations, the electrical conductivity of SLMoS2 is calculated by Boltzmann equations. The thermal conductivity of SLMoS2 is calculated to be as high as 116.8 Wm-1K-1 by molecular dynamics (MD) simulations. The predicted value of ZT is as high as 0.26 at 500K. As the thermal conductivity could be reduced largely by phonon engineering, there should be a high possibility to enhance ZT in the SLMoS2-based materials.
On non-connected pointed Hopf algebras of dimension 16 in characteristic 2
Creators: name: Xiong, Rongchuan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: Let $\mathbb{k}$ be an algebraically closed field. We give a complete classification of non-connected pointed Hopf algebras of dimension $16$ with char$\,\mathbb{k}=2$ that are generated by group-like elements and skew-primitive elements. It turns out that there are infinitely many classes (up to isomorphism) of pointed Hopf algebras of dimension 16. In particular, we obtain infinitely many new examples of non-commutative non-cocommutative finite-dimensional pointed Hopf algebras.
description: 42 pages
Schwinger boson spin liquid states on square lattice
Creators: name: Yang, Xu
name: Wang, Fa
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study possible spin liquids on square lattice that respect all lattice symmetries and time-reversal symmetry within the framework of Schwinger boson (mean-field) theory. Such spin liquids have spin gap and emergent Z_2 gauge field excitations. We classify them by the projective symmetry group method, and find six spin liquid states that are potentially relevant to the J_1-J_2 Heisenberg model. The properties of these states are studied under mean-field approximation. Interestingly we find a spin liquid state that can go through continuous phase transitions to either the Néel magnetic order or magnetic orders of the wavevector at Brillouin zone edge center. We also discuss the connection between our results and the Abrikosov fermion spin liquids.
description: 27 pages, 14 figures, mistakes in Section III corrected, references updated on top of the published version
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse
Creators: name: Majumder, Samarpan
name: Namjoshi, Ojas A.
name: Vanlinn, Michael L.
name: Cromer, Brett A.
name: Clayton, Terry
name: Yin, Wenyuan
name: Cook, James M.
name: Ma, Chunrong
name: Platt, Donna M.
name: Roth, Bryan L.
name: Petrou, Steven
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A series of 3,6-disubstituted β-carbolines was synthesized and evaluated for their in vitro affinities at αxβ3γ2 GABAA/benzodiazepine receptor subtypes by radioligand binding assays in search of α1 subtype selective ligands to treat alcohol abuse. Analogues of β-carboline-3-carboxylate-t-butyl ester (βCCt, 1) were synthesized via a CDI-mediated process and the related 6-substituted β-carboline-3-carboxylates 6 including WYS8 (7) were synthesized via a Sonogashira or Stille coupling processes from 6-iodo βCCt (5). The bivalent ligands of βCCt (32 and 33) were also designed and prepared via a palladium-catalyzed homocoupling process to expand the structure-activity relationships (SAR) to larger ligands. Based on the pharmacophore/receptor model, a preliminary SAR study on 34 analogues illustrated that large substituents at position -6 of the β-carbolines were well tolerated. As expected, these groups are proposed to project into the extracellular domain (LDi region) of GABAA/Bz receptors (see 32 and 33). Moreover, substituents located at position -3 of the β-carboline nucleus exhibited a conserved stereo interaction in lipophilic pocket L1, while N(2) presumably underwent a hydrogen bonding interaction with H1. Three novel β-carboline ligands (βCCt, 3PBC and WYS8), which preferentially bound to α1 BzR subtypes permitted a comparison of the pharmacological efficacies with a range of classical BzR antagonists (flumazenil, ZK93426) from several different structural groups and indicated these β-carbolines were “near GABA neutral antagonists”. Based on the SAR, the most potent (in vitro) α1 selective ligand was the 6-substituted acetylenyl βCCt (WYS8, 7). Earlier both βCCt and 3PBC had been shown to reduce alcohol self-administration in alcohol preferring (P) and high alcohol drinking (HAD) rats but had little or no effect on sucrose self-administration.1–3 These data prompted the synthesis of the β-carbolines presented here.
Supplementary document for 100 Gbps PAM4 ultra-thin photodetectors integrated on SOI platform by micro transfer printing - 6635941.pdf
Creators: name: MUTHUGANESAN, HEMALATHA
name: Mura, Enrica
name: Chugh, Shivangi
name: Antony, Cleitus
name: Pelucchi, Emanuele
name: Townsend, Paul
name: Yan, Xingzhao
name: Banakar, Mehdi
name: Tran, Denh
name: Littlejohns, Callum
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Revised supplementary document is attached
Pole inflation and primordial black holes formation in Starobinsky-like supergravity
Creators: name: Aoki, Shuntaro
name: Ishikawa, Ryotaro
name: Ketov, Sergei V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We extend the Cecotti-Kallosh model of Starobinsky inflation in supergravity by adding a holomorphic function to the superpotential in order to generate a large peak in the power spectrum of scalar (curvature) perturbations. In our approach, the singular non-canonical kinetic terms are largely responsible for inflation (as an attractor solution), whereas the superpotential is engineered to generate a production of primordial black holes. We study the cases with (i) a linear holomorphic function, (ii) a quadratic holomorphic function, and (iii) an exponential holomorphic function, as regards the dependence of inflation and primordial black holes production upon parameters of those functions and initial conditions, as well as verify viability of inflation with our superpotentials. We find that an efficient production of primordial black holes consistent with CMB measurements is only possible in the second (ii) case. We calculate the masses of the produced primordial black holes and find that they are below the Hawking (black hole) evaporation limit, so that they cannot be part of the current dark matter in our Universe.
description: 22 pages, 16 figures, LaTeX; short comments added, figures updated
Supplementary document for 100 Gbps PAM4 ultra-thin photodetectors integrated on SOI platform by micro transfer printing - 6642949.pdf
Creators: name: MUTHUGANESAN, HEMALATHA
name: Mura, Enrica
name: Chugh, Shivangi
name: Antony, Cleitus
name: Pelucchi, Emanuele
name: Townsend, Paul
name: Yan, Xingzhao
name: Banakar, Mehdi
name: Tran, Denh
name: Littlejohns, Callum
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Proof-read supplement document