cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inferring average generation via division-linked labeling
Creators: name: Weber, Tom S.
name: Perie, Leila
name: Duffy, Ken R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Probability (math.PR)
subject: FOS: Biological sciences
subject: FOS: Mathematics
subject: 92D25, 60J85

description: For proliferating cells subject to both division and death, how can one estimate the average generation number of the living population without continuous observation or a division-diluting dye? In this paper we provide a method for cell systems such that at each division there is an unlikely, heritable one-way label change that has no impact other than to serve as a distinguishing marker. If the probability of label change per cell generation can be determined and the proportion of labeled cells at a given time point can be measured, we establish that the average generation number of living cells can be estimated. Crucially, the estimator does not depend on knowledge of the statistics of cell cycle, death rates or total cell numbers. We validate the estimator and illustrate its features through comparison with published data and physiologically parameterized stochastic simulations, using it to suggest new experimental designs.
Cardiomyocyte-specific role of miR-24 in promoting cell survival
Creators: name: Guo, Chuner
name: Qian, Li
name: Liu, Jiandong
name: Deng, Yangmei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cardiomyocyte cell death is a major contributing factor to various cardiovascular diseases and is therefore an important target for the design of therapeutic strategies. More recently, stem cell therapies, such as transplantation of embryonic or induced pluripotent stem (iPS) cell-derived cardiomyocytes, have emerged as a promising alternative therapeutic avenue to treating cardiovascular diseases. Nevertheless, survival of these introduced cells is a serious issue that must be solved before clinical application. We and others have identified a small non-coding RNA, microRNA-24 (miR-24), as a pro-survival molecule that inhibits the apoptosis of cardiomyocytes. However, these earlier studies delivered mimics or inhibitors of miR-24 via viral transduction or chemical transfection, where the observed protective role of miR-24 in cardiomyocytes might have partially resulted from its effect on non-cardiomyocyte cells. To elucidate the cardiomyocyte-specific effects of miR-24 when overexpressed, we developed a genetic model by generating a transgenic mouse line, where miR-24 expression is driven by the cardiac-specific Myh6 promoter. The Myh6-miR-24 transgenic mice did not exhibit apparent difference from their wild-type littermates under normal physiological conditions. However, when the mice were subject to myocardial infarction (MI), the transgenic mice exhibited decreased cardiomyocyte apoptosis, improved cardiac function and reduced scar size post-MI compared to their wild-type littermates. Interestingly, the protective effects observed in our transgenic mice were smaller than those from earlier reported approaches as well as our parallelly performed non-genetic approach, raising the possibility that non-genetic approaches of introducing miR-24 might have been mediated via other cell types than cardiomyocytes, leading to a more dramatic phenotype. In conclusion, our study for the first time directly tests the cardiomyocyte-specific role of miR-24 in the adult heart, and may provide insight to strategy design when considering miRNA-based therapies for cardiovascular diseases.
ТИББИЁТ ОЛИЙ ТАЪЛИМ МУАССАСАЛАРИДА ЛИНГВОДИДАКТИК ТАФАККУРНИ РИВОЖЛАНТИРИШ ОРКАЛИ ТАЛАБАЛАРДА ИНГЛИЗ ТИЛИНИ УКИТИШ САМАРАДОРЛИГИНИ ОШИРИШ
Creators: name: Кадирова, Гўзал
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада тиббиёт ОТМ талабаларига чет тилларини ўқитиш сифатини баҳолаш индекаторларини шакллантириш масаласи, хусусан, инглиз тилини ўқитиш жараёнини баҳолаш кўрсаткичлари ва мезонлари масаласи таҳлили баён қилинган.
Quantum Limits of Measurements and Uncertainty Principle
Creators: name: Ozawa, Masanao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we show how the Robertson uncertainty relation gives certain intrinsic quantum limits of measurements in the most general and rigorous mathematical treatment. A general lower bound for the product of the root-mean-square measurement errors arising in joint measurements of noncommuting observables is established. We give a rigorous condition for holding of the standard quantum limit (SQL) for repeated measurements, and prove that if a measuring instrument has no larger root-mean-square preparational error than the root-mean-square measurement errors then it obeys the SQL. As shown previously, we can even construct many linear models of position measurement which circumvent this condition for the SQL.
description: 15 pages, presented at the International Workshop on Quantum Aspects of Optical Communications, C.N.R.S. Paris, France, November 26-28, 1990
The Fifteen Puzzle- A New Approach through Hybridizing Three Heuristics Methods
Creators: name: Hasan, Dler O.
name: Aladdin, Aso M.
name: Talabani, Hardi Sabah
name: Rashid, Tarik Ahmed
name: Mirjalili, Seyedali
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Fifteen Puzzle problem is one of the most classical problems that have captivated mathematical enthusiasts for centuries. This is mainly because of the huge size of the state space with approximately 1013 states that have to be explored and several algorithms have been applied to solve the Fifteen Puzzle instances. In this paper, to deal with this large state space, Bidirectional A* (BA*) search algorithm with three heuristics, such as Manhattan distance (MD), linear conflict (LC), and walking distance (WD) has been used to solve the Fifteen Puzzle problems. The three mentioned heuristics will be hybridized in a way that can dramatically reduce the number of generated states by the algorithm. Moreover, all those heuristics require only 25KB of storage but help the algorithm effectively reduce the number of generated states and expand fewer nodes. Our implementation of BA* search can significantly reduce the space complexity, and guarantee either optimal or near-optimal solutions.1
description: 18 pages
Translation Regulation and Proteasome Mediated Degradation Cooperate to Keep Stem-Loop Binding Protein Low in G1-Phase: REGULATION OF SLBP EXPRESSION IN G1-PHASE
Creators: name: Köseoğlu, M. Murat
name: Marzluff, William F.
name: Djakbarova, Umidahan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Histone mRNA levels are cell cycle regulated, and the major regulatory steps are at the posttranscriptional level. A major regulatory mechanism is S- phase restriction of Stem-loop binding protein (SLBP) which binds to the 3′ end of histone mRNA and participates in multiple steps of histone mRNA metabolism, including 3′ end processing, translation and regulation of mRNA stability. SLBP expression is cell cycle regulated without significant change in its mRNA level. SLBP expression is low in G1 until just before S phase where it functions and at the end of S phase SLBP is degraded by proteasome complex depending on phosphorylations on Thr 60 and Thr61. Here using synchronized HeLa cells we showed that SLBP production rate is low in early G1 and recovers back to S phase level somewhere between early and mid-G1. Further, we showed that SLBP is unstable in G1 due to proteasome mediated degradation as a novel mechanism to keep SLBP low in G1. Finally, the S/G2 stable mutant form of SLBP is degraded by proteasome in G1, indicating that the SLBP degradation mechanism in G1 is independent of the previously identified S/G2 degradation mechanism. In conclusion, as a mechanism to limit histone production to S phase, SLBP is kept low in G1 phase due to cooperative action of translation regulation and proteasome mediated degradation which is independent of previously known S/G2 degradation.
Fractal AC circuits and propagating waves on fractals
Creators: name: Akkermans, Eric
name: Chen, Joe P.
name: Dunne, Gerald
name: Rogers, Luke G.
name: Teplyaev, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We extend Feynman's analysis of the infinite ladder AC circuit to fractal AC circuits. We show that the characteristic impedances can have positive real part even though all the individual impedances inside the circuit are purely imaginary. This provides a physical setting for analyzing wave propagation of signals on fractals, by analogy with the Telegrapher's Equation, and generalizes the real resistance metric on a fractal, which provides a measure of distance on a fractal, to complex impedances.
description: v2: 9 pages, 4 figures. Updated with recent developments
Fitness Dependent Optimizer with Neural Networks for COVID-19 patients
Creators: name: Abdulkhaleq, Maryam T.
name: Rashid, Tarik A.
name: Hassan, Bryar A.
name: Alsadoon, Abeer
name: Bacanin, Nebojsa
name: Chhabra, Amit
name: Vimal, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: The Coronavirus, known as COVID-19, which appeared in 2019 in China, has significantly affected global health and become a huge burden on health institutions all over the world. These effects are continuing today. One strategy for limiting the virus's transmission is to have an early diagnosis of suspected cases and take appropriate measures before the disease spreads further. This work aims to diagnose and show the probability of getting infected by the disease according to textual clinical data. In this work, we used five machine learning techniques (GWO_MLP, GWO_CMLP, MGWO_MLP, FDO_MLP, FDO_CMLP) all of which aim to classify Covid-19 patients into two categories (Positive and Negative). Experiments showed promising results for all used models. The applied methods showed very similar performance, typically in terms of accuracy. However, in each tested dataset, FDO_MLP and FDO_CMLP produced the best results with 100% accuracy. The other models' results varied from one experiment to the other. It is concluded that the models on which the FDO algorithm was used as a learning algorithm had the possibility of obtaining higher accuracy. However, it is found that FDO has the longest runtime compared to the other algorithms. The link to the covid 19 models is found here: https://github.com/Tarik4Rashid4/covid19models
description: 38 pages
Printed Ottoman Base Model Trained on the OpenITI Corpus
Creators: name: Kiessling, Benjamin
Publisher: name: Zenodo
Year: 2022
Subjects: kraken_pytorch

description: This is a text recognition model trained on the OpenITI dataset of printed Arabic-script text available at [0] in its state of 2022-09-03. It encompasses Ottoman (~7100 lines) material in a variety of typefaces. The model has been obtained by fine-tuning the Arabic-script base model [1] on the purely Ottoman Turkish subset of the corpus. As the model is trained on a variety of highly diverse typefaces it is mostly intended as a base model for fine-tuning more specific models from it. In line with this it has not been extensively verified or optimized. The ground truth was lightly normalized to NFD but is otherwise untouched. [0]: https://github.com/OpenITI/arabic_print_data.git [1]: 10.5281/zenodo.7050270
Bending the Rules: Widefield Microscopy and the Abbe Limit of Resolution
Creators: name: Bloom, Kerry
name: Verdaasdonk, Jolien S.
name: Haase, Julian
name: Stephens, Andrew D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: One of the most fundamental concepts of microscopy is that of resolution–the ability to clearly distinguish two objects as separate. Recent advances such as structured illumination microscopy (SIM) and point localization techniques including photoactivated localization microscopy (PALM), and stochastic optical reconstruction microscopy (STORM) strive to overcome the inherent limits of resolution of the modern light microscope. These techniques, however, are not always feasible or optimal for live cell imaging. Thus, in this review, we explore three techniques for extracting high resolution data from images acquired on a widefield microscope–deconvolution, model convolution, and Gaussian fitting. Deconvolution is a powerful tool for restoring a blurred image using knowledge of the point spread function (PSF) describing the blurring of light by the microscope, although care must be taken to ensure accuracy of subsequent quantitative analysis. The process of model convolution also requires knowledge of the PSF to blur a simulated image which can then be compared to the experimentally acquired data to reach conclusions regarding its geometry and fluorophore distribution. Gaussian fitting is the basis for point localization microscopy, and can also be applied to tracking spot motion over time or measuring spot shape and size. All together, these three methods serve as powerful tools for high-resolution imaging using widefield microscopy.
ТРАНСФОРМАЦИЯ ХОЗЯЙСТВЕННОЙ СИСТЕМЫ И ОБЕСПЕЧЕНИЕ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ
Creators: name: ХАРЛАМОВ АНДРЕЙ ВИКТОРОВИЧ
Publisher: name: Петербургский экономический журнал
Year: 2020
Subjects: ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
ХОЗЯЙСТВЕННАЯ СИСТЕМА
ГЛОБАЛИЗАЦИЯ
НОВЫЕ РИСКИ
ИЗМЕНЕНИЯ
ГОСУДАРСТВЕННОЕ РЕГУЛИРОВАНИЕ
МОБИЛИЗАЦИОННАЯ ЭКОНОМИКА
ECONOMIC SECURITY
ECONOMIC SYSTEM
GLOBALIZATION
NEW RISKS
CHANGES
STATE REGULATION
MOBILIZATION ECONOMY

description: Современный этап социально-экономического развития характеризуетсясистемными трансформациями в большинстве сфер экономической деятельности, в частности, в области экономической безопасности. В соответствии с объективными законами диалектики изменения, постояннопроисходящие в экономике абсолютного большинства стран, включая Россию, требуют соответствия хозяйственной системы задачам, связанным с обеспечением экономической безопасности. Ситуация в глобальнойэкономике, оказавшейся сегодня перед лицом новых рисков, которые вомногом сама и породила, предполагает переосмысление теории и практикиобеспечения экономической безопасности. Появление рисков, с которымистранам невозможно бороться в одиночку, приводит к необходимости объединения их усилий при возрастании значимости государственного регулирования. В контексте борьбы с рисками в данной статье обосновываетсянеобходимость и возможность использования некоторых из принциповмобилизационной экономики.
BASIC EARNING POWER (BEP) PADA LEMBAGA KEUANGAN SYARIAH DAN KONVENSIONAL: PEMETAAN PENELITIAN MENGGUNAKAN STUDI BIBLIOMETRIK VOSVIEWER DAN LITERATURE REVIEW
Creators: name: Budianto, Eka Wahyu Hestya
name: Dewi, Nindi Dwi Tetria
Publisher: name: Zenodo
Year: 2024

description: This study aims to determine the map of research developments regarding determinantvariables and the influence of Basic Earning Power/BEP on Islamic and ConventionalFinancial Institutions using a mix-method approach, namely quantitative methods inbibliometric studies and qualitative methods in literature review studies. The researchobject is Basic Earning Power/BEP. The source of data collection comes from searches ofnational journals indexed by Google Scholar and Sinta through the Perish/Harzingapplication. Data analysis techniques include: (1) mapping RIS data files on MendeleyDesktop based on the order of year, author, and publisher; (2) mapping the results ofvisualization of bibliometric networks and trends in scientific publications using theVOSviewer algorithm software (Visualization of Similarities); and (3) mapping researchtopics. The results showed that the number of publications has increased significantly everyyear. And based on the mapping results using the VOSviewer application and literaturereview, there are 2 main themes around the determinant variables and the influence ofBasic Earning Power/BEP. The implication and contribution of this research is to map topicsthat are often researched by researchers, so that they can find out research gaps, and canbecome a reference for subsequent researchers.
Origin of the Diffuse, Far Ultraviolet Emission in the Interarm Regions of M101
Creators: name: Crocker, Alison F.
name: Chandar, Rupali
name: Calzetti, Daniela
name: Holwerda, Benne Willem
name: Leitherer, Claus
name: Popescu, Cristina
name: Tuffs, R. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present images from the Solar Blind Channel on HST that resolve hundreds of far ultraviolet (FUV) emitting stars in two ~1 kpc$^2$ interarm regions of the grand-design spiral M101. The luminosity functions of these stars are compared with predicted distributions from simple star formation histories, and are best reproduced when the star formation rate has declined recently (past 10-50 Myr). This pattern is consistent with stars forming within spiral arms and then streaming into the interarm regions. We measure the diffuse FUV surface brightness after subtracting all of the detected stars, clusters and background galaxies. A residual flux is found for both regions which can be explained by a mix of stars below our detection limit and scattered FUV light. The amount of scattered light required is much larger for the region immediately adjacent to a spiral arm, a bright source of FUV photons.
description: 11 pages, 9 figures, accepted for publication in ApJ
ВЛИЯНИЕ ТЕНЕВИЗАЦИИ ЭКОНОМИКИ НА ОБЕСПЕЧЕНИЕ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ ОРГАНИЗАЦИЙ
Creators: name: ЛЕЛЯВИНА ТАТЬЯНА АНАТОЛЬЕВНА
name: ШЕХОВЦОВА АННА ВИКТОРОВНА
name: НЕЙГУМ ЕЛИЗАВЕТА АНДРЕЕВНА
Publisher: name: Петербургский экономический журнал
Year: 2020
Subjects: ТЕНЕВИЗАЦИЯ
ТЕНЕВАЯ ЭКОНОМИКА
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
ИНСТРУМЕНТЫ ОБЕСПЕЧЕНИЯ ФИНАНСОВОЙ СТАБИЛЬНОСТИ
ЭКОНОМИЧЕСКИЕ ИНТЕРЕСЫ
НАЛОГОВОЕ РЕГУЛИРОВАНИЕ
SHADOW ECONOMY
ECONOMIC SECURITY
TOOLS FOR ENSURING FINANCIAL STABILITY
ECONOMIC INTERESTS
TAX REGULATION

description: Данная статья посвящена исследованию влияния теневизации экономикина обеспечение экономической безопасности организаций. Необходимостьрассмотрения экономической безопасности предприятий обусловлена нетолько потребностью в обеспечении стабильности и устойчивости экономических процессов, поддержания способности экономических субъектов кпостоянному обновлению и совершенствованию, но и в связи с нарастанием,распространением субъектов, явлений и процессов в экономике, определяемых как нелегальных или теневых. В статье представлены результатыисследования причинно-следственных связей между экономическим ростом, предпринимательской активностью и препятствиями к развитию здоровых экономических отношений, возникающими в результате расширения теневого экономического сектора. Авторами проведено исследование цифровизации теневой экономики, выделены ее сегменты, обозначены тенденции развития теневого сектора, проявляющиеся посредством кримина- лизации. Исследованы ключевые элементы системы теневой экономики. Предложены к рассмотрению варианты действий, препятствующие сбою в обеспечении экономической безопасности.
(400550) isabella Hillocks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Galaxy UV Luminosity Function Before the Epoch of Reionization
Creators: name: Mason, Charlotte
name: Trenti, Michele
name: Treu, Tommaso
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a model for the evolution of the galaxy ultraviolet (UV) luminosity function (LF) across cosmic time where star formation is linked to the assembly of dark matter halos under the assumption of a mass dependent, but redshift independent, efficiency. We introduce a new self-consistent treatment of the halo star formation history, which allows us to make predictions at $z>10$ (lookback time $\lesssim500$ Myr), when growth is rapid. With a calibration at a single redshift to set the stellar-to-halo mass ratio, and no further degrees of freedom, our model captures the evolution of the UV LF over all available observations ($0\lesssim z\lesssim10$). The significant drop in luminosity density of currently detectable galaxies beyond $z\sim8$ is explained by a shift of star formation toward less massive, fainter galaxies. Assuming that star formation proceeds down to atomic cooling halos, we derive a reionization optical depth $τ= 0.056^{+0.007}_{-0.010}$, fully consistent with the latest Planck measurement, implying that the universe is fully reionized at $z=7.84^{+0.65}_{-0.98}$. In addition, our model naturally produces smoothly rising star formation histories for galaxies with $L\lesssim L_*$ in agreement with observations and hydrodynamical simulations. Before the epoch of reionization at $z>10$ we predict the LF to remain well-described by a Schechter function, but with an increasingly steep faint-end slope ($α\sim-3.5$ at $z\sim16$). Finally, we construct forecasts for surveys with \JWST~and \WFIRST and predict that galaxies out to $z\sim14$ will be observed. Galaxies at $z>15$ will likely be accessible to JWST and WFIRST only through the assistance of strong lensing magnification.
description: Accepted for publication in ApJ. 11 pages, 13 figures. Corrected mislabelled redshifts in Figure 6
Cerebral Mitochondrial Metabolism in Early Parkinson's Disease
Creators: name: Golchin, Nima
name: Videen, Tom O
name: Markham, Joanne
name: Perlmutter, Joel S
name: Powers, William J
name: Black, Kevin J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Abnormal cerebral energy metabolism due to dysfunction of mitochondrial electron transport has been implicated in the pathogenesis of Parkinson Disease (PD). However, in vivo data of mitochondrial dysfunction has been inconsistent. We directly investigated mitochondrial oxidative metabolism in vivo in 12 patients with early, never-medicated PD and 12 age-matched normal controls by combined measurements of the cerebral metabolic rate of oxygen (CMRO2) and the cerebral metabolic rate of glucose (CMRglc) with positron emission tomography. The primary analysis showed a statistically significant 24% increase in bihemispheric CMRO2 and no change in CMRO2/CMRglc. These findings are inconsistent with a defect in mitochondrial oxidative phosphorylation due to reduced activity of the mitochondrial ETS. Since PD symptoms were already manifest, deficient energy production due to a reduced activity of the mitochondrial ETS cannot be a primary mechanism of neuronal death in early PD. Alternatively, this general increase in CMRO2 could be due, not to increased metabolic demand, but to an uncoupling of ATP production from oxidation in the terminal stage of oxidative phosphorylation. Whether this is the case in early PD and whether or not it is important in the pathogenesis of PD will require further study.
Gravity Beyond Einstein? Yes, but in Which Direction?
Creators: name: Kazanas, Demosthenes
name: Papadopoulos, Demetrios
name: Christodoulou, Dimitris
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present qualitative arguments in favor of an extension of the theory of the gravitational interaction beyond that resulting from the Hilbert-Einstein action. To this end we consider a locally conformal invariant theory of gravity, discussed some thirty years ago by Mannheim and Kazanas. We discuss its exact solution of the static, spherically symmetric configurations and, based on these, we revisit some of the outstanding problems associated with gravity, high energy interactions and sketch potential resolutions within the conformal gravity framework.
description: 13 pages, 2 figures, published in Philosophical Transactions of the Royal Society A
(400546) Samuel Brodie [jnr] Hill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400547) John [mints] Hill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cerebellum as the Normal Reference for the Detection of Increased Cerebral Oxygen Extraction
Creators: name: Derdeyn, Colin P
name: Powers, William J
name: Videen, Tom O
name: Grubb, Robert L
name: Jiang, Thomas T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Hemispheric ratios of oxygen extraction fraction (OEF), a proven methodology for the detection of severe hemodynamic impairment and stroke risk, are not sensitive for detecting bilateral hemispheric increases in OEF. The aim of this study was to investigate the use of cerebellum as the reference normal. We analyzed positron emission tomographic (PET) measurements of count-based OEF and clinical data from 57 patients with unilateral atherosclerotic carotid occlusion and 13 controls enrolled in a prospective study of stroke risk. The ipsilateral, contralateral, and total cerebellum were each evaluated as possible reference regions, and the ratios of the middle cerebral artery (MCA) hemispheric OEF counts against those in each reference region were determined. A statistically significant correlation (P<0.0001) was observed with all three MCA-to-cerebellar ratios when compared with the gold standard of ipsilateral-to-contralateral MCA hemispheric ratio. Kaplan–Meier analyses showed all MCA-to-cerebellar ratios to be predictive of stroke. By using the total cerebellum method, 7 strokes were found to have occurred in 20 patients with increased OEF (P=0.0007), compared with 7 strokes out of 16 patients with elevated OEF using the ipsilateral or contralateral cerebellum methods (P<0.0001). These methods may be useful for categorizing the hemodynamic status of patients with bilateral cerebral occlusive diseases, including atherosclerosis and moyamoya, to determine the association with the risk of subsequent stroke.
(400548) James Hillocks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Wide Genetic Variation in the Native Pial Collateral Circulation is a Major Determinant of Variation in Severity of Stroke
Creators: name: Zhang, Hua
name: Prabhakar, Pranay
name: Faber, James E
name: Sealock, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Severity of stroke varies widely among individuals. Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown. We addressed these questions and probed for potential genetic contributions using morphometric analysis of the collateral circulation in 15 inbred mouse strains recently shown to exhibit wide differences in infarct volume. Morphometrics were determined in the unligated left hemisphere (for native collaterals) and ligated right hemisphere (for remodeled collaterals) 6 days after permanent middle cerebral artery (MCA) occlusion. Variation among strains in native collateral number, diameter, MCA, anterior cerebral artery (ACA), and posterior cerebral artery (PCA) tree territories were, respectively: 56-fold, 3-fold, 42%, 56%, and 61%. Collateral length (P<0.001) and the number of penetrating arterioles branching from them also varied (P<0.05). Infarct volume correlated inversely with collateral number (P<0.0001), diameter (P<0.0001), and penetrating arteriole number (P<0.05) and directly with MCA territory (P<0.05). Relative collateral conductance and MCA territory, when factored together, strongly predicted infarct volume (P<0.0001). Outward remodeling of collaterals in the ligated hemisphere varied ∼3-fold. These data show that the extent of the native pial collateral circulation and collateral remodeling after obstruction vary widely with genetic background, and suggest that this variability, due to natural polymorphisms, is a major contributor to variability in infarct volume.
АКТУАЛИЗАЦИЯ СОЦИОКУЛЬТУРНЫХ АСПЕКТОВ УПРАВЛЕНИЯ В УСЛОВИЯХ СТАНОВЛЕНИЯ ПРИРОДОСБЕРЕГАЮЩЕЙ ЭКОНОМИКИ
Creators: name: БАЙКОВ ЕВГЕНИЙ АЛЕКСАНДРОВИЧ
Publisher: name: Петербургский экономический журнал
Year: 2020
Subjects: ПРИРОДОСБЕРЕГАЮЩАЯ ЭКОНОМИКА
ПРИРОДНО-ТЕХНИЧЕСКИЕ СИСТЕМЫ
СОЦИАЛЬНАЯ ОТВЕТСТВЕННОСТЬ
СОЦИАЛЬНО-ЭКОЛОГИЧЕСКАЯ ОТВЕТСТВЕННОСТЬ
ЭКОЛОГИЧЕСКАЯ КУЛЬТУРА
ЭТИКА УПРАВЛЕНИЯ
NATURE-SAV ING ECONOMY
NATURAL AND TECHNICAL SYSTEM S
SOCIAL RESPONSIBILITY
SOCIAL AND ENVIRONMENTAL RESPONSIBILITY
ENVIRONMENTAL CULTURE
ETHICS OF THE MANAGEMENT

description: В статье показывается значимость природосберегающих технологийи инноваций для перспективного развития отечественной экономики.Обосновывается актуальность социокультурных аспектов управления вдеятельности природно-технических систем. В качестве таких аспектовавтор рассматривает социальную ответственность менеджмента, социально-экологическую ответственность, экологическую культуру, этикууправления в интересах природоохранной деятельности. Предлагается отдельно выделять в социальной ответственности менеджмента в качествесамостоятельного уровня социально-экологическую ответственность. Показана взаимосвязь экологической культуры с организационной культуройи этикой управления. Основными принципами профессиональной этики,этики профессий руководителя и менеджера предлагается считать сбережение окружающей среды, рациональное использование природных ресурсови экологическую безопасность.
Bounds of memory strength for power-law series
Creators: name: Guo, Fangjian
name: Yang, Dan
name: Yang, Zimo
name: Zhao, Zhi-Dan
name: Zhou, Tao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Many time series produced by complex systems are empirically found to follow power-law distributions with different exponents $α$. By permuting the independently drawn samples from a power-law distribution, we present non-trivial bounds on the memory strength (1st-order autocorrelation) as a function of $α$, which are markedly different from the ordinary $\pm 1$ bounds for Gaussian or uniform distributions. When $1 < α\leq 3$, as $α$ grows bigger, the upper bound increases from 0 to +1 while the lower bound remains 0; when $α> 3$, the upper bound remains +1 while the lower bound descends below 0. Theoretical bounds agree well with numerical simulations. Based on the posts on Twitter, ratings of MovieLens, calling records of the mobile operator Orange, and browsing behavior of Taobao, we find that empirical power-law distributed data produced by human activities obey such constraints. The present findings explain some observed constraints in bursty time series and scale-free networks, and challenge the validity of measures like autocorrelation and assortativity coefficient in heterogeneous systems.
description: 10 pages, 4 figures (revised)
Metabolic Control of Resting Hemispheric Cerebral Blood Flow is Oxidative, not Glycolytic
Creators: name: Markham, Joanne
name: Powers, William J
name: Perlmutter, Joel S
name: Walter, Vonn
name: Videen, Tom O
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Although the close regional coupling of resting cerebral blood flow (CBF) with both cerebral metabolic rate of oxygen (CMRO2) and cerebral metabolic rate of glucose (CMRglc) within individuals is well documented, there are few data regarding the coupling between whole brain flow and metabolism among different subjects. To investigate the metabolic control of resting whole brain CBF, we performed multivariate analysis of hemispheric CMRO2, CMRglc, and other covariates as predictors of resting CBF among 23 normal humans. The univariate analysis showed that only CMRO2 was a significant predictor of CBF. The final multivariate model contained two additional terms in addition to CMRO2: arterial oxygen content and oxygen extraction fraction. Notably, arterial plasma glucose concentration and CMRglc were not included in the final model. Our data demonstrate that the metabolic factor controlling hemispheric CBF in the normal resting brain is CMRO2 and that CMRglc does not make a contribution. Our findings provide evidence for compartmentalization of brain metabolism into a basal component in which CBF is coupled to oxygen metabolism and an activation component in which CBF is controlled by another mechanism.
Electromagnetic Structure of Few-Nucleon Ground States
Creators: name: Marcucci, L. E.
name: Gross, F.
name: Pena, M. T.
name: Piarulli, M.
name: Schiavilla, R.
name: Sick, I.
name: Stadler, A.
name: Van Orden, J. W.
name: Viviani, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Experimental form factors of the hydrogen and helium isotopes, extracted from an up-to-date global analysis of cross sections and polarization observables measured in elastic electron scattering from these systems, are compared to predictions obtained in three different theoretical approaches: the first is based on realistic interactions and currents, including relativistic corrections (labeled as the conventional approach); the second relies on a chiral effective field theory description of the strong and electromagnetic interactions in nuclei (labeled $χ$EFT); the third utilizes a fully relativistic treatment of nuclear dynamics as implemented in the covariant spectator theory (labeled CST). For momentum transfers below $Q \lesssim 5$ fm$^{-1}$ there is satisfactory agreement between experimental data and theoretical results in all three approaches. However, at $Q \gtrsim 5$ fm$^{-1}$, particularly in the case of the deuteron, a relativistic treatment of the dynamics, as is done in the CST, is necessary. The experimental data on the deuteron $A$ structure function extend to $Q \simeq 12$ fm$^{-1}$, and the close agreement between these data and the CST results suggests that, even in this extreme kinematical regime, there is no evidence for new effects coming from quark and gluon degrees of freedom at short distances.
description: 66 pages, 23 figures, topical review submitted to J. Phys. G: Nucl. Part. Phys
Emociones. Del dolor y gloria de María
Creators: name: Cirlot, Victoria
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Affects
Mysticism
Survivals
Lucio Fontana
Bill Viola

description: Preceded by a brief introduction, the text offers an extract from the catalogue text of the exhibition Emociones. Imágenes y gestos del pasado y del presente (Barcelona, Museu Frederic Marès, 30 November - 26 May 2024), written by the exhibition's curator, Victoria Cirlot. Through a comparison of a selection of sculptures from the late Middle Ages and the Renaissance from the museum's collections, and works from the 20th century and the early part of the 21st - including works by Tàpies, Fontana, Viola and Riera - the figure of Mary, Mother of God, in the transition from her sorrow to her joy, will be highlighted as a common thread, following a division into three sections: I. El dolor de Maria, II. La ferida de Cristo, and III. La glòria de Maria. The comparative supratemporal recontextualisation makes comparisons and perceptive enrichments possible, in which the figure of the Virgin stands as the prototype of one who achieves precisely the fullness of glory (and thus of joy) through the fullness of suffering, and as an emblematic image of com-passion, in the literal sense of her participation in the death of her Son.
СОВРЕМЕННЫЕ ПАРАДИГМЫ РОССИЙСКОГО РИТЕЙЛА
Creators: name: СИНЯВСКАЯ ЕЛЕНА ЕВГЕНЬЕВНА
Publisher: name: Петербургский экономический журнал
Year: 2020
Subjects: ТОРГОВЛЯ
РОЗНИЧНАЯ ТОРГОВЛЯ
РИТЕЙЛ
ТЕНДЕНЦИИ РАЗВИТИЯ РОЗНИЧНОЙ ТОРГОВЛИ
ОНЛАЙН И ОФЛАЙН ТОРГОВЛЯ
ОМНИКАНАЛЬНАЯ МОДЕЛЬ
TRADE
RETAIL
TRENDS IN RETAIL DEVELOPMENT
ONLINE AND OFFLINE TRADE
OMNI-CHANNEL MODEL

description: Торговля - это комплексный и системообразующий сектор экономики страны, который является ключевым донором валового внутреннего продукта.В статье представлены результаты проведенного ретроспективного анализа, на основе которого определено влияние макроэкономических факторовна развитие торговли, выявлены тенденции современного российского ритейла. Ограничения, введенные во время пандемии COVID-19, изменили привычную деятельность, трансформировали старые и сгенерировали новыетренды развития розничной торговли, что привело к изменению парадигмы российского ритейла. Конкурентные преимущества получат те субъектыотрасли, которые сделают ставку на омниканальность и e-commerce.
A Thesis Submitted to School of Commerce for Partial Fulfilment of the Requirements for the Award of Degree of Master in Human Resource Management
Creators: name: Biruk Hussen
Publisher: name: Zenodo
Year: 2019

description: The purpose of this study is to assess the impact of training on employee performance. To tackle the research problem, the researcher had as major objective to find out: whether Ethiopian Police University College has training programs, policy, and methods conducted for all employees; possible training measurement technique and the practical effects training has on the performance of employees. The study used the simple random sampling technique to select permanent employees from all directorates. The researcher got information from 172 respondents through questionnaires, interview, and personal observation. The research reveals that training led to a positive impact on the performance of employee and an improvement in their skills and commitment. It is recommended that Ethiopian Police University College shall participate employees on designing and planning training programs, It should also has training program evaluation technique as well as performance measurement technique
(400544) Barbara [Johnston]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Uniqueness of dg enhancements for the derived category of a Grothendieck category
Creators: name: Canonaco, Alberto
name: Stellari, Paolo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Category Theory (math.CT)
subject: FOS: Mathematics

description: We prove that the derived category of a Grothendieck abelian category has a unique dg enhancement. Under some additional assumptions, we show that the same result holds true for its subcategory of compact objects. As a consequence, we deduce that the unbounded derived category of quasi-coherent sheaves on an algebraic stack and the category of perfect complexes on a noetherian concentrated algebraic stack with quasi-finite affine diagonal and enough perfect coherent sheaves have a unique dg enhancement. In particular, the category of perfect complexes on a noetherian scheme with enough locally free sheaves has a unique dg enhancement.
description: 32 pages. This version fills a gap in the proof of the previous Theorem C which now appears with slightly stronger hypotheses. The main results (Theorems A and B and their geometric applications) are unchanged
Platelet Mitochondrial Complex I and I+III Activities Do Not Correlate with Cerebral Mitochondrial Oxidative Metabolism
Creators: name: Markham, Joanne
name: Perlmutter, Joel S
name: Le, Thuy
name: Powers, William J
name: Videen, Tom O
name: Haas, Richard H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Assays of mitochondrial electron transport system (ETS) activity in circulating blood platelets have been used to investigate the cause of neurodegenerative diseases. However, the correspondence between platelet ETS function and cerebral mitochondrial metabolism is not well characterized. To assess the validity of using platelet ETS activity to infer cerebral mitochondrial metabolism, we measured platelet ETS activity (complex I and complex I+III), cerebral metabolic rate of oxygen (CMRO2), and the CMRO2/cerebral metabolic rate for glucose ratio in 40 subjects: 7 with never-medicated Parkinson's disease, 13 with genetically proved Huntington's disease, and 20 normal controls. We found no correlation between in vivo measures of cerebral mitochondrial oxidative metabolism and ex vivo assays of platelet complex I and complex I+III activity performed on blood collected immediately before cerebral metabolism studies. We saw no evidence of a threshold effect when comparing platelet complex I and complex I+III activity with cerebral oxidative metabolism across a 4- to 10-fold range of platelet ETS activity. On the basis of these data, we conclude that measures of mitochondrial complex I and I+III activity in platelets within the ranges we have studied do not correlate with oxidative function of cerebral mitochondria.
Quantum phase-space representation for curved configuration spaces
Creators: name: Gneiting, Clemens
name: Fischer, Timo
name: Hornberger, Klaus
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We extend the Wigner-Weyl-Moyal phase-space formulation of quantum mechanics to general curved configuration spaces. The underlying phase space is based on the chosen coordinates of the manifold and their canonically conjugate momenta. The resulting Wigner function displays the axioms of a quasiprobability distribution, and any Weyl-ordered operator gets associated with the corresponding phase-space function, even in the absence of continuous symmetries. The corresponding quantum Liouville equation reduces to the classical curved space Liouville equation in the semiclassical limit. We demonstrate the formalism for a point particle moving on two-dimensional manifolds, such as a paraboloid or the surface of a sphere. The latter clarifies the treatment of compact coordinate spaces as well as the relation of the presented phase-space representation to symmetry groups of the configuration space.
description: Typo in Eq. (82) corrected and missing terms in Eq. (85) added. These corrections are also described in the erratum Phys. Rev. A 106, 069904(E) (2022). 14 pages
Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease
Creators: name: Burbank, Raquel R
name: Muir, Eric
name: Javors, Martin
name: Halloran, Jonathan J
name: Richardson, Arlan G
name: Hussong, Stacy A
name: Galvan, Veronica
name: Hart, Matthew J
name: Shih, Yen-Yu Ian
name: Lin, Ai-Ling
name: Lechleiter, James D
name: Strong, Randy
name: Zheng, Wei
name: Fonseca, Rene Solano
name: Fox, Peter T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Vascular pathology is a major feature of Alzheimer's disease (AD) and other dementias. We recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor rapamycin, which extends lifespan and delays aging, halts the progression of AD-like disease in transgenic human (h)APP mice modeling AD when administered before disease onset. Here we demonstrate that chronic reduction of TOR activity by rapamycin treatment started after disease onset restored cerebral blood flow (CBF) and brain vascular density, reduced cerebral amyloid angiopathy and microhemorrhages, decreased amyloid burden, and improved cognitive function in symptomatic hAPP (AD) mice. Like acetylcholine (ACh), a potent vasodilator, acute rapamycin treatment induced the phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) and NO release in brain endothelium. Administration of the NOS inhibitor L-NG-Nitroarginine methyl ester reversed vasodilation as well as the protective effects of rapamycin on CBF and vasculature integrity, indicating that rapamycin preserves vascular density and CBF in AD mouse brains through NOS activation. Taken together, our data suggest that chronic reduction of TOR activity by rapamycin blocked the progression of AD-like cognitive and histopathological deficits by preserving brain vascular integrity and function. Drugs that inhibit the TOR pathway may have promise as a therapy for AD and possibly for vascular dementias.