cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes
Creators: name: Pollack, G. M.
name: Brouwer, K. L. R.
name: Wolf, K. K.
name: Brouwer, K. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The purpose of the present study was to evaluate the effects of bovine serum albumin (BSA) and essentially fatty acid-free BSA (BSA-FAF) on the biliary clearance of compounds in sandwich-cultured rat hepatocytes. Unbound fraction (fu), biliary excretion index (BEI), and unbound intrinsic biliary clearance (intrinsic Cl’biliary) were determined for digoxin, pravastatin, and taurocholate in the absence or presence of BSA or BSA-FAF. BSA had little effect on the BEI or intrinsic Cl’biliary of these compounds. Surprisingly, BSA-FAF decreased both BEI and intrinsic Cl’biliary for digoxin and pravastatin, which represent low and moderately-bound compounds, respectively. The BEI and intrinsic Cl’biliary of taurocholate, a highly-bound compound, were not altered significantly by BSA-FAF. Neither BSA nor BSA-FAF had a discernable effect on the bile canalicular networks, based on carboxydichlorofluorescein (CDF) retention. The addition of physiological concentrations of calcium, or the addition of fatty acids to BSA-FAF, was unable to restore the BEI or intrinsic Cl’biliary of the model compounds to similar values in the absence or presence of BSA. Careful consideration is warranted when selecting the type of BSA for addition to in vitro systems such as sandwich-cultured rat hepatocytes.
title: Structural and functional studies of caveolae in the femoral artery
Creators: name: Albrakati, Ashraf
Publisher: name: University of Liverpool Repository
Year: 2014

description: Caveolae are important microdomains found in the plasma membrane, which act as signalling hubs in endothelial cells (ECs) and smooth muscle cells (SMCs). Thus, disruption of caveolae by membrane cholesterol depleting agents such as methyl β-cyclodextrin (M-β-CD) has various functional effects on arteries, including impairment of endothelium-dependent relaxation and augmentation of smooth muscle cell contraction independently of the endothelium. The aim of this study was to test the hypotheses that caveolae modulate contractility in rat femoral artery, and more specifically the response to BKCa channel activity. Different methods were used in the study including; transmission electron microscopy (TEM), immunohistochemistry, immunocytochemistry and Western blot, and myography. M-β-CD was used in this work to disrupt caveolae from the plasma membranes of SMCs and ECs of rat femoral artery. TEM examination showed that caveolae were present throughout the plasma membrane of the SMCs and ECs in femoral artery. TEM examination also showed that treatment of the artery with M-β-CD, causes removal of caveolae from most of plasma membrane of the SMCs and ECs. Immunohistochemistry and immunocytochemistry results showed that cav-1, cav-3 and BKCa channels are co-expressed in SMCs, and cav-1 and BKCa channels are present in ECs. The presence of these proteins in femoral artery tissue lysate was confirmed by Western blot. Femoral artery contraction studies using myography showed that caveolar disruption by M-β-CD caused a significant increase in the contraction in endothelium-intact artery rings in response to 20 mM K+ and 100 nM BayK-8644 (20 K/ Bay K). In endothelium-denuded artery rings and/or after incubation of endothelium-intact artery rings with L-NAME (an eNOS inhibitor), there was a non-significant increase in the contraction in response to 20K/ BayK. Incubation of endothelium-intact artery rings with TEA+ or IBTX, both BKCa channel inhibitors, caused a significant increase in the contraction to 20 K/ Bay K. Incubation of endothelium-intact artery rings with L-NAME, reduced the contraction to TEA+ and IBTX. These results provide evidence that contraction of rat femoral artery is inhibited by basal nitric oxide release from the endothelium, and BKCa channels in the SMCs might have a role in this vasorelaxation. Further femoral artery relaxation studies showed that the integrity of caveolae was important for the vasorelaxation of arteries (pre-contracted with 20 K/ Bay K) when BKCa channels were directly activated by NS-1619. In contrast, vasorelaxation by isoproterenol and forskolin in endothelium-denuded artery was not significantly altered after caveolae were disrupted. These data together suggest that caveolae are an important factor in maintaining Ca2+ homeostasis in SMCs in rat artery femoral due to regulation of contractile activation.
Choreographies and Behavioural Contracts on the Way to Dynamic Updates
Creators: name: Bravetti, Mario
name: Zavattaro, Gianluigi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We survey our work on choreographies and behavioural contracts in multiparty interactions. In particular theories of behavioural contracts are presented which enable reasoning about correct service composition (contract compliance) and service substitutability (contract refinement preorder) under different assumptions concerning service communication: synchronous address or name based communication with patient non-preemptable or impatient invocations, or asynchronous communication. Correspondingly relations between behavioural contracts and choreographic descriptions are considered, where a contract for each communicating party is, e.g., derived by projection. The considered relations are induced as the maximal preoders which preserve contract compliance and global traces: we show maximality to hold (permitting services to be discovered/substituted independently for each party) when contract refinement preorders with all the above asymmetric communication means are considered and, instead, not to hold if the standard symmetric CCS/pi-calculus communication is considered (or when directly relating choreographies to behavioral contracts via a preorder, no matter the communication mean). The obtained maximal preorders are then characterized in terms of a new form of testing, called compliance testing, where not only tests must succeed but also the system under test (thus relating to controllability theory), and compared with classical preorders such as may/must testing, trace inclusion, etc. Finally, recent work about adaptable choreographies and behavioural contracts is presented, where the theory above is extended to update mechanisms allowing choreographies/contracts to be modified at run-time by internal (self-adaptation) or external intervention.
description: In Proceedings MOD* 2014, arXiv:1411.3453
Atractides (Atractides) undetermined
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hygrobatidae
Atractides
Atractides undetermined

description: Atractides (Atractides) sp.
(Fig. 2A–D)
New records: India, Assam State, Basistha stream, 24. xii. 2009, leg. Das & Bordoloi, 0/1/0 (mounted).
Morphology. Female: Dorsal integument striated; muscle attachment plates unsclerotized. Coxal field (Fig. 2A): caudal margin of Cx-I strongly curved, apodemes of Cx-II directed laterally; coxal field L 356; Cx-III W 434; Cx-I+II mL 138; lL Cx-I+II 250. Genital field (Fig. 2C): pregenital sclerite curved, Ac in a triangle, genital plate L 117, L Ac- 1–3 48, 52, 49. Excretory pore smooth; Vgl-1 not fused to Vgl-2.
Palp (Fig. 2B): total L 306, dL (%L in parentheses): P-1, 28 (9.2); P-2, 65 (21.2); P-3, 88 (28.8); P-4, 92 (30.1); P-5, 33 (10.8); L ratio P-2/P-4, 0.71; P-2 ventral margin straight; P-3 ventral margin slightly concave, bearing one pair of setae (one seta in rigth palp); P-4 club-shaped, sword seta strong, inserted between ventral hairs.
I-L (Fig. 2D): I-L-5 setal interspace narrow, S-1 longish, blunt, S-2 basally enlarged, pointed; I-L-6 robust, weakly curved; I-L-5 dL 185, vL 134, dL/vL ratio 1.38, HB 43, dL/HB 4.3, S-1 L 86, L/W 12.5, S-2 L 75, L/W 6.1, distance S- 1-2 15, L ratio S-1/2 1.14; I-L-6 L 132, HB 25, L/HB ratio 5.4; L ratio I-L-5/6 1.4.
Remarks: Due to the ventral margin of P-3 bearing one or two ventral setae, the specimen from the Basistha stream can be distinguished from other members of this subgenus. Probably, this specimen represent a species new to science. However, a description and definitive diagnosis can be given only if the new taxon is known in both sexes.
Habitat: Streams.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 26, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
THE IMPACT OF COVID-19 ON SOCIAL PROBLEMS AMONG MIGRANT WORKERS IN CHENNAI DISTRICT, TAMILNADU
Creators: name: C. DAVID
name: T. PUGALETNHI
Publisher: name: Zenodo
Year: 2023
Subjects: ---

description: Abstract
India, migrant workers confront a variety of difficulties and threats, including exploitation, harassment, assault, trafficking, bonded labour, low pay, unsafe working conditions, and lack of social protection, health concerns, and exclusion from development initiatives. To analyse basic social aspects and the impact of COvid 19 of migrant workers. To find the association between social problems and Covid-19. In the field of migration studies, there has been very less number of research on the relationship between pandemics and migration before COVID-19. In general, there has been growing attention in the field to the key topic of health-related migration. When people living in this motherland work in different parts of the country to support their families financially through construction workers, hotel workers, miners, cleaners, agricultural workers, restaurant workers, retail, transport workers, social workers, maid and so on they face lot of problems out of them one is social aspects. This research made an attempt to bring the problems faced by the migrant worries during the pandemic situation. The p-value (Sig.) associated with the F-statistic is 0.029, 0.011, 0.007, 0.316, 0.003, and 0.000 of gender, age, marital status religion education and duration of stay in Chennai respectively. Since the p-value is lesser than the typical significance level of 0.05, the null hypothesis (H0) is rejected and H1 is accepted based on the results of the ANOVA. The statistical analysis is concluded that there is a constant relationship between the social aspects among the emigrant workers
title: Search for a Higgs Boson in the H->ZZ and ZH->ll+invisible channels with the ATLAS detector
Creators: name: Price, Joseph
Publisher: name: University of Liverpool Repository
Year: 2014

description: A pre-data sensitivity study to search for a high mass Standard Model (SM) Higgs (m_H = 200 GeV) in ATLAS using the H -> ZZ -> llll channel is presented. It is found that it would be possible to exclude a SM Higgs in part of this high mass region with limited luminosity. Using this channel a search at the LHC for the SM Higgs boson in the first ~40 inverse picobarns of data was conducted and is presented in this thesis, along with the results from the H->ZZ->llvv and H->ZZ->llqq channels using a similar dataset. It is found that the channel with the best sensitivity to a SM Higgs with mass greater than 200 GeV is the H->ZZ->llll channel. A search for the SM Higgs boson using the H->ZZ->llvv channel is presented, using 4.7 inverse femtobarns of data at a centre-of-mass energy of s = 7 TeV. A Higgs boson with a mass between 320 and 560 GeV is excluded at a 95\% confidence level using this channel alone. This analysis was published in 2011 and updated in 2012, and results from this search are used in the ATLAS paper, describing the discovery of a new Higgs-like boson with ~m_H = 125 GeV. Finally a direct search is performed for anomalous invisible decays of the Higgs boson candidate at ~125 GeV using both the 2011 dataset and the 2012 dataset at centre-of-mass energy s = 7 and 8 TeV respectively. An upper limit of 65% is set on the allowed H->inv branching fraction at 95% confidence level. Additional searches are performed using the same dataset on further invisibly decaying Higgs-like bosons at masses between 115 and 300 GeV. No excess is observed. This analysis was published as a preliminary result in March 2013, and a paper using the full 2011 and 2012 datasets is scheduled to be published in the summer of 2013.
Supplementary document for Advanced active polymer probe for near-field optics - 6524685.pdf
Creators: name: Chen, Hongshi
name: jiang, quanbo
name: Issa, Ali
name: Li, Borui
name: GE, Dandan
name: Jradi, Safi
name: Lalevée, Jacques
name: Marguet, Sylvie
name: deturche, regis
name: Couteau, Christophe
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Nanophotonics

description: Supplemental Document
title: Argumentation-based dialogues over cooperative plans
Creators: name: Medellin Gasque, Angel Rolando
Publisher: name: University of Liverpool Repository
Year: 2014

description: If autonomous agents operating with other agents in open systems are to fulfil their goals and design objectives, the need to discuss and agree upon plans of action is imperative. In this thesis I present work covering both theoretical research and practical development related to the use of argumentation-based dialogues as a way to coordinate actions in multi-agent planning scenarios. The necessity of coordination in multi-agent systems requires the development of mechanisms to propose, modify, share, monitor, and argue about plans. In this thesis I present an argumentation scheme to propose multi-agent plans and associated critical questions to critique the proposal. Such a detailed consideration of multi-agent plan composition contains the right characteristics to enable the justification of plans.This research builds upon research on practical reasoning for action proposals and considers multi-agent plan proposals where plans require several agents for their execution. A dialogue game protocol is also presented which is based on proposal framework. The protocol allows agents to engage in dialogues to agree on and modify plans based on persuasion and deliberation protocols. The detail encompassed by the argumentation scheme and critical questions means that there is a large number of critical questions, and so dialogues may be very lengthy. To overcome this issue, I investigated the issue of strategies for use with this dialogue game in terms of the different possible orderings in which critiques can be posed. The thesis presents an implementation that realises the theoretical framework in terms of a agents engaging in simulated dialogues to share and agree on a plan. The experiments allow us to investigate the effects of such strategies in terms of the number of questions issued to reach an agreement. Overall, the framework presented in this thesis allow agents to engage in dialogues over cooperative plan proposals in a structured way using well-founded argumentative principles.
Detectability of Cosmic Dark Flow in the Type Ia Supernova Redshift-Distance Relation
Creators: name: Mathews, G. J.
name: Rose, B.
name: Garnavich, P.
name: Yamazaki, D.
name: Kajino, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We re-analyze the detectability of large scale dark flow (or local bulk flow) with respect to the CMB background based upon the redshift-distance relation for Type Ia supernovae (SN Ia). We made two independent analyses: one based upon identifying the three Cartesian velocity components; and the other based upon the cosine dependence of the deviation from Hubble flow on the sky. We apply these analyses to the Union2.1 SN Ia data and to the SDSS-II supernova survey. For both methods, results for low redshift, $z < 0.05$, are consistent with previous searches. We find a local bulk flow of $v_{\rm bf} \sim 300$ km s$^{-1}$ in the direction of $(l,b) \sim (270, 35)^{\circ}$. However, the search for a dark flow at $z>0.05$ is inconclusive. Based upon simulated data sets, we deduce that the difficulty in detecting a dark flow at high redshifts arises mostly from the observational error in the distance modulus. Thus, even if it exists, a dark flow is not detectable at large redshift with current SN Ia data sets. We estimate that a detection would require both significant sky coverage of SN Ia out to $z = 0.3$ and a reduction in the effective distance modulus error from 0.2 mag to $\lesssim 0.02$ mag. We estimate that a greatly expanded data sample of $\sim 10^4$ SN Ia might detect a dark flow as small as 300 km s$^{-1}$ out to $z = 0.3$ even with a distance modulus error of $0.2$ mag. This may be achievable in a next generation large survey like LSST.
description: 12 pages, 11 figures, resubmitted to ApJ
An Approach to Model Checking of Multi-agent Data Analysis
Creators: name: Garanina, Natalia
name: Bodin, Eugene
name: Sidorova, Elena
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Multiagent Systems (cs.MA)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The paper presents an approach to verification of a multi-agent data analysis algorithm. We base correct simulation of the multi-agent system by a finite integer model. For verification we use model checking tool SPIN. Protocols of agents are written in Promela language and properties of the multi-agent data analysis system are expressed in logic LTL. We run several experiments with SPIN and the model.
description: In Proceedings MOD* 2014, arXiv:1411.3453
Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)
Creators: name: Brouwer, K. L. R.
name: Lee, J. K.
name: Wen, Z.
name: Hawke, R. L.
name: Smith, P. C.
name: Miranda, S. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Silymarin, an extract from seeds of Silybum marianum, is used by 8-33% of patients to self-treat chronic viral hepatitis C in the United States. Studies in humans and rodents suggest that biliary excretion of glucuronide and sulfate conjugates is the major route for silymarin’s elimination. To determine the role of multidrug resistance associated-protein 2, Mrp2 (Abcc2), in the biliary excretion of silymarin, the hepatobiliary disposition of the six major silymarin flavonolignans was studied using isolated perfused livers (IPRLs) from wild-type (WT) and Mrp2-deficient (TR-) Wistar rats. For all flavonolignans, approximately 96% of the dose was cleared from perfusate within 30 min in both WT and TR- livers, and < 5% of parent was recovered in bile or perfusate by the end of the perfusion. In WT livers, the percentage of dose excreted as conjugates into bile varied for each flavonolignan (silychristin, 51.6% ± 9.3; silydianin, 101.5% ± 28.3; silybin A, 21.0% ± 8.3; silybin B, 31.7% ± 13.2; isosilybin A, 50.5% ± 23.6; isosilybin B, 42.8% ± 19.3). Among the flavonolignans, only silydianin was primarily glucuronidated and almost completely recovered in bile. In TR- livers, biliary excretion of flavonolignan conjugates was reduced 80-92%, with 30-83% of each flavonolignan conjugate recovered in perfusate compared to only 5-30% at 90 min. Biliary excretion of glucuronide and sulfate conjugates of all flavonolignans were reduced by 94-98% and 73-84% respectively, in TR- IPRLs. These data indicate a primary role for Mrp2 in the biliary elimination of silymarin flavonolignan conjugates.
Dynamics of an Ion Coupled to a Parametric Superconducting Circuit
Creators: name: Kafri, Dvir
name: Adhikari, Prabin
name: Taylor, Jacob M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Superconducting circuits and trapped ions are promising architectures for quantum information processing. However, the natural frequencies for controlling these systems -- radio frequency ion control and microwave domain superconducting qubit control -- make direct Hamiltonian interactions between them weak. In this paper we describe a technique for coupling a trapped ion's motion to the fundamental mode of a superconducting circuit, by applying to the circuit a carefully modulated external magnetic flux. In conjunction with a non-linear element (Josephson junction), this gives the circuit an effective time-dependent inductance. We then show how to tune the external flux to generate a resonant coupling between the circuit and ion's motional mode, and discuss the limitations of this approach compared to using a time-dependent capacitance.
description: 10 pages, 4 figures
Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
Creators: name: Annaert, P. P.
name: Augustijns, P.
name: Yanni, S. B.
name: Thakker, D. R.
name: Benjamin, D. K.
name: Bridges, A.
name: Gao, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Voriconazole is a potent second generation triazole antifungal agent with broad-spectrum activity against clinically important fungi. It is cleared predominantly via metabolism in all species tested including humans. N-oxidation of the fluoropyrimidine ring, its hydroxylation, and hydroxylation of the adjacent methyl group are the known pathways of voriconazole oxidative metabolism, with the N-oxide being the major circulating metabolite in human. In vitro studies have shown that CYP2C19, CYP3A4, and to a lesser extent CYP2C9 contribute to the oxidative metabolism of voriconazole. When CYP-specific inhibitors and antibodies were used to evaluate the oxidative metabolism of voriconazole by human liver microsomes (HLM), the results suggested that CYP-mediated metabolism accounted for ~75% of the total oxidative metabolism. The studies presented here provide evidence that the remaining ~25% of the metabolic transformations are catalyzed by flavin-containing monooxygenase (FMO). This conclusion was based on the evidence that the NADPH-dependent metabolism of voriconazole was sensitive to heat (45 °C for 5 min), a condition known to selectively inactivate FMO without affecting CYP activity. The role of FMO in the metabolic formation of voriconazole N-oxide was confirmed by the use of recombinant FMO enzymes. Kinetic analysis of voriconazole metabolism by FMO1 and FMO3 yielded Km values of 3.0 mM and 3.4 mM and Vmax values of 0.025 pmol/min/pmol and 0.044 pmol/min/pmol, respectively. FMO5 did not metabolize voriconazole effectively. This is the first report of the role of FMO in the oxidative metabolism of voriconazole.
A Language Support for Exhaustive Fault-Injection in Message-Passing System Models
Creators: name: Suzuki, Masaya
name: Watanabe, Takuo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D 2.4

description: This paper presents an approach towards specifying and verifying adaptive distributed systems. We here take fault-handling as an example of adaptive behavior and propose a modeling language Sandal for describing fault-prone message-passing systems. One of the unique mechanisms of the language is a linguistic support for abstracting typical faults such as unexpected termination of processes and random loss of messages. The Sandal compiler translates a model into a set of NuSMV modules. During the compilation process, faults specified in the model will be woven into the output. One can thus enjoy full-automatic exhaustive fault-injection without writing faulty behaviors explicitly. We demonstrate the advantage of the language by verifying a model of the two-phase commit protocol under faulty environment.
description: In Proceedings MOD* 2014, arXiv:1411.3453
TMT-proteomics of Day 7 Piglet and adult liver.xlsx
Creators: name: Wolfgang, Michael
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310205
subject: Proteomics and metabolomics

description: Yorkshire pigs in postnatal seven days old (p7) (n=6, 1 male, 5 females), and Adult Yorkshire pig livers (n= 6, 3 males, 3 females) were utilized. Liver protein was extracted from liver with equal masses using RIPA buffer with protease inhibitors. Next, liver homogenates were submitted to the Johns Hopkins Center for Proteomics Core for complete proteome analysis using traditional mass spectrometry (MS)-based approaches to identify and quantify proteins.
Presentation at Rossio Infraestructure - Coordination Meeting (June 2022)
Creators: name: Rossio Infrastructure
Publisher: name: Zenodo
Year: 2022

description: Coordination Meeting with Consortium ROSSIO partners and content providers, (online/ presential), 29 June 2022, NOVA FCSH (Av. de Berna, 26 C, Auditório 1) and Zoom.
Incompatibility of time-dependent Bogoliubov--de-Gennes and Ginzburg--Landau equations
Creators: name: Frank, Rupert L.
name: Hainzl, Christian
name: Schlein, Benjamin
name: Seiringer, Robert
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the time-dependent Bogoliubov--de-Gennes equations for generic translation-invariant fermionic many-body systems. For initial states that are close to thermal equilibrium states at temperatures near the critical temperature, we show that the magnitude of the order parameter stays approximately constant in time and, in particular, does not follow a time-dependent Ginzburg--Landau equation, which is often employed as a phenomenological description and predicts a decay of the order parameter in time. The full non-linear structure of the equations is necessary to understand this behavior.
description: to appear in LMP
title: An examination of the relationship between depression, autobiographical memory specificity and executive function
Creators: name: Malone, Catherine
Publisher: name: University of Liverpool Repository
Year: 2014

description: This thesis is submitted in partial fulfilment of a Doctorate in Clinical Psychology at the University of Liverpool. It focuses on the frequently reported finding of reduced specificity of autobiographical memory in participants diagnosed with depression (Williams & Broadbent; 1986, van Vreeswijk & de Wilde; 2004). That is, difficulty recalling the who, what, where and when, of a remembered event. The focus of investigation particularly within the thesis is that of executive functioning; a term describing a range of higher order cognitive functions that control and integrate other activities such as planning, sequencing, initiation. It is examined in relation to depression. The thesis is presented in paper form; Chapter 1 contains a systematic review of 9 research studies related to executive function in the memory specificity of participants with a diagnosis of depression. While executive functioning does appear to be related to reduced specificity the findings in the literature are not consistent highlighting the need for further research. The original empirical paper presented in Chapter 2 tests out hypotheses related to the claims of reduced specificity and executive functioning in participants with a diagnosis of depression (Burt, Zembar, & Niederehe, 1995). These hypotheses are based on the conclusions drawn from the review paper in Chapter 1. It concludes that while overall participants with a diagnosis of depression produce fewer memories overall, and particularly fewer specific memories, this difference can be reduced with modified materials which are more concrete and imaginable. These modified materials can also produce more specific memories overall. In addition, regardless of depression status, executive functioning has a significant impact on autobiographical memory specificity. These key findings are developed in an extended discussion in Chapter 3 and discussed in terms of their value and application to practices in clinical psychology. Chapter 3 also contains research dissemination for participants and a future research proposal expanding the scope of investigation from depression to trauma.
Meta-Metamodel-Independent Model Transformations
Creators: name: Zech, Philipp
Publisher: name: Zenodo
Year: 2025

description: This repository contains the artifact for our SEAA 2025 submission entitled "Meta-Metamodel-Independent Model Transformations". Please see the README for further details.

CAUTION: This artifact is a development resource and provided on a best-effort basis. It thus might still contain unresolved bugs.
Atractides (Megabates) orientalis Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hygrobatidae
Atractides
Atractides orientalis

description: Atractides (Megabates) orientalis (Cook, 1967)
Records from the study area: Tamil Nadu– “ Megabates orientalis ” Cook (1967); Prasad (1974).
Habitat: Mountain streams.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 27, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Literature review of societal perceptions of wildfire risk and mitigation behaviours. A report for the RESAS Strategic Research Programme project 'The impacts of climate change on Natural Capital (JHI-D5-2)
Creators: name: Martino, Simone
name: Rivington, Mike
Publisher: name: Zenodo
Year: 2022
Subjects: Natural Capital
Wildfire
Risk perceptions
Scotland
Mitigation behaviours

description: The aim of this review is to explore information on risk perception relevant to wildfires arising from climate change in Scotland. This literature review provides information on: Common theories of risk perception and methods for its analysis. Insights on the relationships between risk perception and risk behaviour. The objective is to provide information informing responses to four key questions: What factors influence the perception of risk; What are the actions taken to mitigate this risk; What are the factors that incentivise individuals and communities to take specific mitigation actions; How does communication change behaviours? The purpose of this review is to help inform the development of research activities on wildfire and climate change risk perception within Work Package 3 in the project ‘Climate Change Impacts on Natural Capital’. Through assessing risk perception and mitigation behaviours in the context of wildfires, we aim to develop an improved understanding of the theories of risk and mitigation behaviour that can then be utilised in the broader context of climate change impacts, particularly in respect of Natural Capital and Nature Based Solutions.
Competing, Collaborating or Coexisting: the Effect of Methanogens on Chain Elongation
Creators: name: Allaart, Maximilienne Toetie
name: Kerstjens, Marjolein
name: Sousa, Diana Zita
name: Kleerebezem, Robbert
Publisher: name: Zenodo
Year: 2024

description: Conference presentation at ICBM-4 in Braga about the effect of methanogen presence on chain-elongating microbial communities
title: A molecular approach to study gene flow between wild, weedy, and cultivated rice in South and Southeast Asia
Creators: name: Augustine Tensaout, Hayeit
Publisher: name: University of Liverpool Repository
Year: 2023

description: Gene flow amongst AA genome rice species Oryza sativa (cultivated rice) and 0. rufipogon and 0. nivara (wild relatives) is known to occur in rice agro-ecosystems in many Asian countries. Gene flow leads to the formation of hybrid plants that may coexist with parental species. These hybrids (especially 'weedy rice'- plants that are very similar to cultivars but possessing undesirable traits) are a threat to rice production as they may reduce cultivated rice yields, both qualitatively and quantitatively. The precise origins of 'weedy' rice (WR) genotypes are unknown but two main hypotheses have been proposed: endoferality (by segregation and selection of weedy traits from existing heterozygous cultivars in areas where no wild rice exists) and exoferality via gene flow between cultivated and wild rice species. With a continuous growing world population especially in Asia, food demand has to be satisfied with an increase in rice production, playing a key role.
The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans
Creators: name: Paine, M. F.
name: Roberts, P. J.
name: Kashuba, A. D. M.
name: Moran, C.
name: Lamba, J. K.
name: Schuetz, E. G.
name: Hawke, R. L.
name: Williams, E. E.
name: Rollins, K. D.
name: Nelsen, A. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The CYP3A5*1 allele has been associated with differences in the metabolism of some CYP3A substrates. CYP3A5 polymorphism may also influence susceptibility for certain drug interactions. We have previously noted a correlation between basal CYP3A activity and the inductive effects of dexamethasone using the erythromycin breath test (ERBT). To determine if CYP3A5 polymorphism influences induction of CYP3A activity, we examined the effect of an anti-emetic regimen of dexamethasone, and the prototypical inducer rifampin, on the ERBT in a African American volunteers prospectively stratified by CYP3A5*1 allele carrier-status. Mean basal ERBTs were significantly higher in CYP3A5*1 carriers (2.71% ± 0.53%) versus non-carriers (2.12% ± 0.37%, P = 0.006). Rifampin increased ERBTs in CYP3A5*1 carriers (4.68% vs 2.60%, P = 0.0008) and non-carriers (3.55% vs 2.11%, P = 0.0017), while dexamethasone increased ERBTs only in CYP3A5*1 non-carriers (3.03% vs 2.14%, P = 0.031). CYP3A5 polymorphism appears to influence susceptibility to induction-type drug interactions for some inducers, and CYP3A5*1 non-carriers may be more susceptible to the inductive effects of dexamethasone due to lower basal CYP3A activity.
title: Understanding of the use of alcohol in pregnancy amongst women in Scotland
Creators: name: Ford, Katharine
Publisher: name: University of Liverpool Repository
Year: 2014

description: This thesis examines the use of alcohol in pregnancy amongst women in Scotland, post the introduction of a recommendation for abstinence in 2007 from alcohol during pregnancy. There is an ongoing debate over this recommendation, with some researchers highlighting abstinence as the safest choice but others indicating that such advice may generate excess fear and stress to mothers and can also be a way of stigmatising and controlling women. I argue that an increase in women’s alcohol consumption has also initiated a marked increase in attention towards the role of alcohol in women’s lives and the risks of drinking alcohol during pregnancy. This growing emphasis of the concern towards women drinking during pregnancy has come from the extension of the medicalisation of motherhood and the perception that the maternal-foetal relationship is strained. Biographical narrative interviews with 22 women in Edinburgh and Inverness are used to explore women's alcohol consumption during pregnancy in Scotland. Primarily with the aim to further the understanding of the social and cultural context of women’s alcohol consumption during pregnancy by examining women’s attitudes towards drinking during pregnancy and their awareness of the risks of consuming alcohol during pregnancy. It is my contention that there are many complex themes involved in women’s choices around drinking during pregnancy and that the change to abstinence has further led to the messages women receive being inconsistent, which leaves women in a state of confusion. I maintain that it is important that we recognise that women have different attitudes towards alcohol. Women cannot associate themselves with generalised statements about harm and risk. I explore how women respond to health interventions and their attitudes towards existing public health campaigns and health interventions. Consequently, I contend that women in this study reveal mixed attitudes towards these interventions as they often feel they gloss over the individuality of these decisions and their complexity within women’s lives by using a ‘one size fits all’ approach. Women therefore challenged the notion of harm and the evidence base behind the guidance, leading to a lack of confidence in the medical profession and an increasing reliance on lay health beliefs. It also draws upon the often overlooked importance of pleasure in women’s choices around alcohol consumption. The study highlights the importance of women’s experience, and the necessity of talking to women to further understand what influences their decision making around alcohol consumption during pregnancy. I argue that an attempt to trigger concern in pregnant women is inappropriate because of the lack of evidence into the risks caused by even moderate alcohol consumption.
Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier
Creators: name: Bacon, J. A.
name: Raub, T. J.
name: Pollack, G. M.
name: Sawada, G. A.
name: Bridges, A. S.
name: Zhao, R.
name: Kasper, S. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been revealed recently. To investigate comprehensively the potential role of Bcrp at the murine BBB, a chemically diverse set of model compounds (cimetidine, alfuzosin, dipyridamole, and LY2228820) was evaluated using a multiexperimental design. Bcrp1 stably transfected MDCKII cell monolayer transport studies demonstrated that each compound had affinity for Bcrp and that polarized transport by Bcrp was abolished completely by the Bcrp inhibitor chrysin. However, none of the compounds differed in brain uptake between Bcrp wild-type and knockout mice under either an in situ brain perfusion or a 24-h subcutaneous osmotic minipump continuous infusion experimental paradigm. In addition, alfuzosin and dipyridamole were shown to undergo transport by P-glycoprotein (P-gp) in an MDCKII-MDR1 cell monolayer model. Alfuzosin brain uptake was 4-fold higher in mdr1a(–/–) mice than in mdr1a(+/+) mice in in situ and in vivo studies, demonstrating for the first time that it undergoes P-gp-mediated efflux at the BBB. In contrast, P-gp had no effect on dipyridamole brain penetration in situ or in vivo. In fact, in situ BBB permeability of these solutes appeared to be primarily dependent on their lipophilicity in the absence of efflux transport, and in situ brain uptake clearance correlated with the intrinsic transcellular passive permeability from in vitro transport and cellular accumulation studies. In summary, Bcrp mediates in vitro transport of various compounds, but seems to play a minimal role at the BBB in vivo.
title: Phonological and Orthographic Processing of Chinese Characters in China, Hong Kong and Taiwan
Creators: name: Wing-Yee Lee, Anna
Publisher: name: University of Liverpool Repository
Year: 2023

description: Chinese, a non-alphabetic language, is composed of characters made up of strokes and radicals. Unlike English, there are no grapheme-phoneme rules in Chinese. However, there are some orthographic-phonological rules related to the phonetic radical which could give some degree of phonological information to the character. Chinese characters are used in China, Hong Kong and Taiwan. The type of character used and the instruction methods are different in these places. China uses simplified characters while Hong Kong and Taiwan use traditional characters. Children in China and Taiwan learn to use a phonetic system before learning characters while Hong Kong children learn by rote. How do the three groups differ in their phonological and orthographic processes? Twenty-five adult participants from each place were compared on a series of phonological and orthographic tasks. The phonological tasks included reading aloud real and pseudo-characters. The orthographic tasks included radical-completion tasks and a lexical decision task. It was found that the three groups shared the same central processing patterns and their differences could be explained by the different types of characters used and the absence or presence of a phonetic script. Two important characteristics of the component radical were identified: its type frequency and its sequence effects. The type frequency suggested the influence of its neighbours and the sequence effect suggested a writing sequence influence. Prelim~nary modifications to the existing lnteractiveactivation framework and the Interactive Constituency Model were attempted to illustrate how the component radicals might be represented in the mental lexicon. Theoretical implications and further research were discussed in the domain of developmental studies with both normal and disordered populations.
Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
Creators: name: Pollack, G. M.
name: Yanni, S. B.
name: Zhao, R.
name: Bridges, A. S.
name: Kalvass, J. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine. Initial in vivo experiments with 24-h subcutaneous osmotic minipump administration demonstrated that fexofenadine brain penetration was 48-fold higher in mdr1a(–/–) mice than in mdr1a(+/+) mice. In contrast, the P-gp efflux ratio at the blood-brain barrier (BBB) for fexofenadine was only ∼4 using an in situ brain perfusion technique. Pharmacokinetic modeling based on the experimental results indicated that the apparent fexofenadine P-gp efflux ratio is time-dependent due to low passive permeability at the BBB. Fexofenadine brain penetration after terfenadine administration was ∼25- to 27-fold higher than after fexofenadine administration in both mdr1a(+/+) and mdr1a(–/–) mice, consistent with terfenadine metabolism to fexofenadine in murine brain tissue. The fexofenadine formation rate after terfenadine in situ brain perfusion was comparable with that in a 2-h brain tissue homogenate in vitro incubation. The fexofenadine formation rate increased ∼5-fold during a 2-h brain tissue homogenate incubation with hydroxyl-terfenadine, suggesting that the hydroxylation of terfenadine is the rate-limiting step in fexofenadine formation. Moreover, regional brain metabolism seems to be an important factor in terfenadine brain disposition and, consequently, fexofenadine brain exposure. Taken together, these results indicate that the fexofenadine BBB P-gp efflux ratio has been underestimated previously due to the lack of complete equilibration of fexofenadine across the blood-brain interface under typical experimental paradigms.
Glucuronidation and Covalent Protein Binding of Benoxaprofen and Flunoxaprofen in Sandwich-Cultured Rat and Human Hepatocytes
Creators: name: Smith, P. C.
name: Dong, J. Q.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Benoxaprofen (BNX), a nonsteroidal anti-inflammatory drug (NSAID) that was withdrawn because of hepatotoxicity, is more toxic than its structural analog flunoxaprofen (FLX) in humans and rats. Acyl glucuronides have been hypothesized to be reactive metabolites and may be associated with toxicity. Both time- and concentration-dependent glucuronidation and covalent binding of BNX, FLX, and ibuprofen (IBP) were determined by exposing sandwich-cultured rat hepatocytes to each NSAID. The levels of glucuronide and covalent protein adduct measured in cells followed the order BNX > FLX > IBP. These results indicate that 1) BNX-glucuronide (G) is more reactive than FLX-G, and 2) IBP-G is the least reactive metabolite, which support previous in vivo studies in rats. The proportional increases of protein adduct formation for BNX, FLX, and IBP as acyl glucuronidation increased also support the hypothesis that part of the covalent binding of all three NSAIDs to hepatic proteins is acyl glucuronide-dependent. Moreover, theses studies confirmed the feasibility of using sandwich-cultured rat hepatocytes for studying glucuronidation and covalent binding to hepatocellular proteins. These studies also showed that these in vitro methods can be applied using human tissues for the study of acyl glucuronide reactivity. More BNX-protein adduct was formed in sandwich-cultured human hepatocytes than FLX-protein adduct, which not only agreed with its relative toxicity in humans but also was consistent with the in vitro findings using rat hepatocyte cultures. These data support the use of sandwich-cultured human hepatocytes as an in vitro screening model of acyl glucuronide exposure and reactivity.
title: Complement and endotoxins in equine colic
Creators: name: Mark Senior, Jonathan
Publisher: name: University of Liverpool Repository
Year: 2023

description: Colic (abdominal pain) is a relatively common disease of horses ranging from mild, transient episodes to a life-threatening syndrome that requires surgical intervention. Equine intestinal abnormalities that involve local stasis are often accompanied by marked proliferation of Gram negative enteric bacteria and breakdown of the mucosal barrier resulting in the transmural and transvascular migration of bacteria and their endotoxins into the circulation (endotoxaemia). Even if the original cause of colic is corrected or resolved, the presence of endotoxaemia can isult in significant morbidity and mortality in horses. This project aimed to characterise specific equine complement component, complement 1 esterase-inhibitor (Cl-inh) because it is considered a key inhibitor of the connplement, coagulation and contact activation pathways.