cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title:  Comuniștii și corupția administrației românești, 1924-1926
Creators: name: Diac, Cristina
Publisher: name: Roma TrE-Press
Year: 2014

description: Abstract:

Studiul de față își propune să releve o fațetă mai puțin cunoscută a comunismului interbelic, respectiv relația non-conflictuală, înscrisă în cutume, dintre PCdR și autoritățile statului. Am în vedere originea acestei situații, plasată în primii ani după interzicerea partidului (1924-1926). Plec de la ipoteza că reprezentarea autorității de stat pe care a avut-o Elek Köblös, secretarul general al PCdR dintre 1924 și 1928, a influențat decizia comuniștilor de a trata cu statul. Această convingere a coincis cu viziunea Cominternului dintre 1922 și 1924, cu privire la rolul Ajutorului Roșu Internațional, viziune modificată în cursul anilor 1925-1926, când centrul de greutate se mută dinspre ajutorarea victimelor «terorii albe» spre campanii propagandistice.

Abstract:

Communist Party of Romania and corruption of the Romanian State apparatus, 1924-1926. This study aims to discuss a mostly unknown issue of interwar Romanian communism: the special relationship established between Party and State, based on financial incentives. This situation is originated in early stages of illegal times (1924-1926). At the beginning, the Comintern supported this kind of unorthodox practice. But from 1925, on the background of struggle for power in Bolshevik Party, the International Red Aid came after those who had worked with the ‛class enemy’, in order to protect the Party.
description: KRYPTON – VOL.4 – 2014 – DENARO
Einheit und Vielfalt der Aspekte der Eucharistie
Creators: name: Kasper, Walter
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 14 Nr. 3 (1985): Internationale katholische Zeitschrift Communio, Band 14, Heft 3
Quantum limits of covert target detection
Creators: name: Tham, Guo Yao
name: Nair, Ranjith
name: Gu, Mile
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In covert target detection, Alice attempts to send optical or microwave probes to determine the presence or absence of a weakly-reflecting target embedded in thermal background radiation within a target region, while striving to remain undetected by an adversary, Willie, who is co-located with the target and collects all light that does not return to Alice. We formulate this problem in a realistic setting and derive quantum-mechanical limits on Alice's error probability performance in entanglement-assisted target detection for any fixed level of her detectability by Willie. We demonstrate how Alice can approach this performance limit using two-mode squeezed vacuum probes in the regime of small to moderate background brightness, and how such protocols can outperform any conventional approach using Gaussian-distributed coherent states. In addition, we derive a universal performance bound for non-adversarial quantum illumination without requiring the passive-signature assumption.
description: 20 pages, 5 figures
MOESM1 of Anopheles aquasalis transcriptome reveals autophagic responses to Plasmodium vivax midgut invasion
Creators: name: Santana, Rosa
name: Oliveira, Maurício
name: Cabral, Iria
name: Junior, Rubens
name: Sousa, Débora
name: Ferreira, Lucas
name: Lacerda, Marcus
name: Wuelton Monteiro
name: Abrantes, Patrícia
name: Guerra, Maria
name: Silveira, Henrique
Publisher: name: Figshare
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. List of primers used in qRT-PCR analysis.
Evidence of interrelated cognitive-like capabilities in large language models: Indications of artificial general intelligence or achievement?
Creators: name: Ilić, David
name: Gignac, Gilles E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Large language models (LLMs) are advanced artificial intelligence (AI) systems that can perform a variety of tasks commonly found in human intelligence tests, such as defining words, performing calculations, and engaging in verbal reasoning. There are also substantial individual differences in LLM capacities. Given the consistent observation of a positive manifold and general intelligence factor in human samples, along with group-level factors (e.g., crystallized intelligence), we hypothesized that LLM test scores may also exhibit positive intercorrelations, which could potentially give rise to an artificial general ability (AGA) factor and one or more group-level factors. Based on a sample of 591 LLMs and scores from 12 tests aligned with fluid reasoning (Gf), domain-specific knowledge (Gkn), reading/writing (Grw), and quantitative knowledge (Gq), we found strong empirical evidence for a positive manifold and a general factor of ability. Additionally, we identified a combined Gkn/Grw group-level factor. Finally, the number of LLM parameters correlated positively with both general factor of ability and Gkn/Grw factor scores, although the effects showed diminishing returns. We interpreted our results to suggest that LLMs, like human cognitive abilities, may share a common underlying efficiency in processing information and solving problems, though whether LLMs manifest primarily achievement/expertise rather than intelligence remains to be determined. Finally, while models with greater numbers of parameters exhibit greater general cognitive-like abilities, akin to the connection between greater neuronal density and human general intelligence, other characteristics must also be involved.
description: 9 pages, 2 figures
Theoretical Modeling of Low-Energy Electronic Absorption Bands in Reduced Cobaloximes
Creators: name: Field, Martin J.
name: Bhattacharjee, Anirban
name: Arantes, Guilherme M.
name: Gray, Harry B.
name: Dempsey, Jillian L.
name: Chavarot-Kerlidou, Murielle
name: Muckerman, James T.
name: Fujita, Etsuko
name: Fontecave, Marc
name: Artero, Vincent
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The reduced Co(I) states of cobaloximes are powerful nucleophiles that play an important role in the hydrogen-evolving catalytic activity of these species. In this work we have analyzed the low energy electronic absorption bands of two cobaloxime systems experimentally and using a variety of density functional theory and molecular orbital ab initio quantum chemical approaches. Overall we find a reasonable qualitative understanding of the electronic excitation spectra of these compounds but show that obtaining quantitative results remains a challenging task.
Light Sparticles from a Light Singlet in Gauge Mediation
Creators: name: Allanach, B. C.
name: Badziak, M.
name: Hugonie, C.
name: Ziegler, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We revisit a simple model that combines minimal gauge mediation and the next-to-minimal supersymmetric standard model. We show that one can obtain a 125 GeV Standard Model-like Higgs boson with stops as light as 1.1 TeV, thanks to the mixing of the Higgs with a singlet state at O(90-100) GeV. Sparticle searches at the LHC may come with additional b-jets or taus and may involve displaced vertices. The sparticle production cross-section at the 13 TeV LHC can be O(10-100) fb, leading to great prospects for discovery in the early phase of LHC Run II.
description: 5 pages, 1 figure. v2 has added electroweak cross-section information and comments about the domain wall problem and warm dark matter constraints. v4 has two additional references
Celebrating 10 Years of re3data
Creators: name: Weisweiler, Nina Leonie
name: Bertelmann, Roland
Publisher: name: Zenodo
Year: 2022
Subjects: research data, repositories, re3data, anniversary

description: The year 2022 marks the 10th anniversary of the Registry of Research Data Repositories, re3data. The global index currently lists almost 3000 digital repositories across all scientific disciplines – critical infrastructures to enable the global exchange of research data. The openly accessible service is used by researchers and services worldwide. It provides extensive descriptions of repositories based on a detailed and publicly available metadata schema. New suggestions and change requests for re3data are managed by an experienced team of editors. The editorial process includes a multi-stage review. An international team of experts thoroughly analyzes the repositories and takes care of metadata completeness and quality. The poster presents the growth, development, and accomplishments of re3data over the past 10 years that have resulted in re3data becoming the most comprehensive and largest information and metadata resource on research data repositories. The poster highlights and summarizes important activities like the initial projects funded by the German Research Foundation (DFG), the collaboration and merger with DataBib, and the partnership with DataCite. It also details collaborations like the EU Open Science Monitor, SNF, and FAIR-enabling measures together with the European Community. The poster addresses activities with different research communities in order to initiate intensive talks about best practices and experience made. Furthermore, it highlights the current projects re3data COREF (Community Driven Open Reference for Research Data Repositories / DFG funded) and FAIR Impact (EU funded).
Lyapunov exponents for products of rectangular real, complex and quaternionic Ginibre matrices
Creators: name: Ipsen, J. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the joint density of eigenvalues for products of independent rectangular real, complex and quaternionic Ginibre matrices. In the limit where the number of matrices tends to infinity, it is shown that the joint probability density function for the eigenvalues forms a permanental point process for all three classes. The moduli of the eigenvalues become uncorrelated and log-normal distributed, while the distribution for the phases of the eigenvalues depends on whether real, complex or quaternionic Ginibre matrices are considered. In the derivation for a product of real matrices, we explicitly use the fact that all eigenvalues become real when the number of matrices tends to infinity. Finally, we compare our results with known results for the Lyapunov exponents as well as numerical simulations.
description: 16 pages, 3 figures
Four point function of $\mathcal{N}=4$ stress-tensor multiplet at strong coupling
Creators: name: Gonçalves, Vasco
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this short note we use the flat space limit and the relation between the 4-pt correlation function of the bottom and top components of the stress tensor multiplet to constraint its stringy corrections at strong coupling in the planar limit. Then we use this four point function to compute corrections to the anomalous dimension of double trace operators of the Lagrangian density and to compute energy-energy correlators at strong coupling.
description: 25 pages; Typos fixed, improved OPE analysis, added references
Paving over arbitrary MASAs in von Neumann algebras
Creators: name: Popa, Sorin
name: Vaes, Stefaan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: We consider a paving property for a maximal abelian *-subalgebra (MASA) $A$ in a von Neumann algebra $M$, that we call so-paving, involving approximation in the so-topology, rather than in norm (as in classical Kadison-Singer paving). If $A$ is the range of a normal conditional expectation, then so-paving is equivalent to norm paving in the ultrapower inclusion $A^ω\subset M^ω$. We conjecture that any MASA in any von Neumann algebra satisfies so-paving. We use [MSS13] to check this for all MASAs in $\mathcal B(\ell^2 \mathbb N)$, all Cartan subalgebras in amenable von Neumann algebras and in group measure space II$_1$ factors arising from profinite actions. By [P13], the conjecture also holds true for singular MASAs in II$_1$ factors, and we obtain here an improved paving size $C\varepsilon^{-2}$, which we show to be sharp.
description: v3: Minor changes, final version, to appear in Analysis and PDE. v2: Minor corrections, plus addition of a complete characterization of MASAs that are norm pavable
Tunable Visible and Near-IR Photoactivation of Light-Responsive Compounds by Using Fluorophores as Light-Capturing Antennas
Creators: name: Lawrence, David S.
name: Shell, Thomas A.
name: Shell, Jennifer R.
name: Rodgers, Zachary L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Although the corrin ring of vitamin B12 is unable to efficiently absorb light beyond 550 nm, it is shown that commercially available fluorophores can be used as antennas to capture long-wavelength light to promote scission of the Co-C bond at wavelengths up to 800 nm. The ability to control the molecular properties of bioactive species with long visible and near-IR light has implications for drug delivery, nanotechnology, and the spatiotemporal control of cellular behavior.
A Theoretical Perspective on the Photochemistry of Boron-Nitrogen Lewis Adducts
Creators: name: Marsili, Emanuele
name: Curchod, Basile F. E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Boron-Nitrogen (B-N) Lewis adducts form a versatile family of compounds with numerous applications in functional molecules. Despite the growing interest in this family of compounds for optoelectronic applications, little is currently known about their photophysics and photochemistry. Even the electronic absorption spectrum of ammonia borane, the textbook example of a B-N Lewis adduct, is unavailable. Given the versatility of the light-induced processes exhibited by these molecules, we propose in this work a detailed theoretical study of the photochemistry and photophysics of simple B-N Lewis adducts. We used advanced techniques in computational photochemistry to identify and characterize the possible photochemical pathways followed by ammonia borane, and extended this knowledge to the substituted B-N Lewis adducts pyridine-borane and pyridine-boric acid. The photochemistry observed for this series of molecules allows us to extract qualitative rules to rationalize the light-induced behavior of more complex B-N containing molecules.
Quantum geometry encoded to pair potentials
Creators: name: Daido, Akito
name: Kitamura, Taisei
name: Yanase, Youichi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Bloch wave functions of electrons have properties called quantum geometry, which has recently attracted much attention as the origin of intriguing physical phenomena. In this paper, we introduce the notion of the quantum-geometric pair potentials (QGPP) based on the generalized band representation and thereby clarify how the quantum geometry of electrons is transferred to the Cooper pairs they form. QGPP quantifies the deviation of multiband superconductors from an assembly of single-band superconductors and has a direct connection to the quantum-geometric corrections to thermodynamic coefficients. We also discuss their potential ability to emulate exotic pair potentials and engineer intriguing superconducting phenomena including topological superconductivity.
description: 12 pages, 2 figures (+8 pages)
Additional file 2: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells
Creators: name: Jo, Eun
name: Lee, Young
name: Hyunjoo Lee
name: Park, Jae
name: Hyojun Park
name: Yoon-La Choi
name: Doopyo Hong
name: Kim, Sung
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Table S2. Combination index (CI) values. (DOCX 26 kb)
Exploring the role of MPP8 in epithelial to mesenchymal transition mechanisms: establishing preliminary conditions and resources for future investigations.
Creators: name: Robinson, Jacob E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Introduction: Prostate cancer is the second most lethal cancer for men in the United States. For approximately 20% of patients, the cancer will eventually spread outside of the prostate and become metastatic prostate cancer (mPC). Once it becomes mPC, patients are treated with traditional cytotoxic chemotherapy as well as targeted therapy. For nearly all patients, treatment response is only temporary and mPC progression continues. Among these patients, 20% patients will further progress to the most devastating and lethal form of prostate cancer: neuroendocrine prostate cancer (NEPC). In NEPC, epigenetic changes are common, and genes that cause cancer growth and metastasis are expressed at a higher rate. The project described herein provides the preliminary steps for supporting further investigations to assess how the epigenetic reader protein, MPP8, has a role as a potential central catalyst in mPC progression.
Methods: The preclinical models utilized in these investigations are LNCaP, C4-2B and the described establishment of a 5 μM enzalutamide-resistant mPC model (MDVR5R). Each of these models were exposed to varying treatment conditions with enzalutamide and a novel covalent MPP8 antagonist compound developed at the UNC CICBDD (UNC7713). Migration and proliferation assays were performed to evaluate the phenotypic effects of treatment conditions, and protocols for gene and protein expression were optimized.
Results: MDVR5R was successfully established, as demonstrated by the increased resistance to enzalutamide, compared to C4-2B and MDVR (non-conditioned) lines. A library of cells to be used for RNA and protein extraction was created to promote future work. It includes samples at baseline with no treatment conditions, chronic treatment growth conditions while developing enzalutamide resistance, and acute treatment conditions with UNC7713 and enzalutamide. IC50 of 1μM was established in LNCaP and C4-2B lines to guide future investigations. Wound closure assay results demonstrated MDVR5R resistance to enzalutamide, as well as migration patterns consistent with epithelial phenotypes, when treated with UNC7713 across all three cell models.
Conclusions: The results described within this report provide preliminary data supporting the establishment of an enzalutamide resistant cell model, MDVR5R. We also provide preliminary data suggesting UNC7713 may have an effect on mPC model systems and their cancer-like characteristics. Future investigations are warranted.
A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
Creators: name: Eram, Mohammad S.
name: Luo, Xiao
name: Szewczyk, Magdalena M.
name: Vedadi, Masoud
name: Dong, Aiping
name: Smil, David
name: Jin, Jian
name: Yang, Xiaobao
name: Huang, Xi-Ping
name: Atadja, Peter
name: Schapira, Matthieu
name: Min, Sun-Joon
name: Brown, Peter J.
name: Barsyte-Lovejoy, Dalia
name: Arrowsmith, Cheryl H.
name: Zang, Irene
name: Li, Fengling
name: Lin, Ying
name: Zhao, Kehao
name: Kennedy, Steven
name: Roth, Bryan L.
name: Lin-Jones, Jennifer
name: Landon, Melissa
name: Dai, Miao
name: He, Feng
name: Yu, Zhengtian
name: Dobrovetsky, Elena
name: Kaniskan, H. Ümit
name: Schmidt, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in several diseases. A potent, selective, and cell- active PRMT3 inhibitor would be a valuable tool for further investigating PRMT3 biology. Here we report the discovery of the first PRMT3 chemical probe, SGC707, by structure-based optimization of the allosteric PRMT3 inhibitors we reported previously, and thorough characterization of this probe in biochemical, biophysical, and cellular assays. SGC707 is a potent PRMT3 inhibitor (IC50 = 31 ± 2 nm, KD = 53 ± 2 nm) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3-SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well- characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.
Charging the Renewable Transition: Modeling the Role of Battery Storage in the Energy Grid
Creators: name: Rubenstein, Hannah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Several strands of literature study the economics of energy grids. One recent working paper (Holland, Mansur, and Yates 2022) creates an economic model based on a social planner’s optimization problem: under economic and technological constraints, what role would different electricity generation and storage technologies play in long-run equilibrium? I extend this paper’s theoretical model by modifying the quality of the battery and the elasticity of demand for electricity. Theoretically, accounting for batteries’ loss of charge during charging and discharging should decrease the role of storage in long-run equilibrium, while making demand less elastic should increase its role. I seek to answer the question: when changing these two assumptions in the model, which effect dominates? Under what conditions does battery storage play a large role in a long-run equilibrium model of the energy grid? I present three key findings. First, battery capacity is 0 when demand for electricity is least elastic (-0.001) and the battery cost is highest (baseline), if the round-trip efficiency is 70% or lower. Second, for a 75% reduced cost battery, one arc elasticity of charging losses relative to elasticity is 0.5063; for a 95% reduced cost battery, one arc elasticity of charging losses relative to elasticity is 3.7801. Third, for a -0.05 elasticity case, one arc elasticity of charging losses relative to battery cost is 5. 6057; for a -0.001 elasticity case, one arc elasticity of charging losses relative to battery cost is 8. 7977.
Magnetic flux eruptions at the root of time-lags in low-luminosity AGN
Creators: name: Vos, Jesse
name: Davelaar, Jordy
name: Olivares, Hector
name: Brinkerink, Christiaan
name: Falcke, Heino
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Sagittarius A$^\ast$ is a compact radio source at the center of the Milky Way that has not conclusively shown evidence for the presence of a relativistic jet. Nevertheless, indirect methods at radio frequencies do indicate consistent outflow signatures. Temporal shifts between features in frequency bands are known as time lags, associated with flares or outflows of the accretion system. It is possible to gain information on the emission and outflow mechanics by interpreting these time lags. By means of a combined general-relativistic magnetrohydrodynamical and radiative transfer modeling, we study the origin of the time-lags for magnetically arrested disc models at three black hole spins ($a_\ast \in \{ -0.9375, 0, 0.9375 \}$). We exclusively modeled the emission from the source across a frequency range of $ν$ = 19-47 GHz. Our study also includes a targeted `slow light' study for one of the best-fitting `fast light' windows. We recovered the observational time-lag relations in various windows of our simulated light curves. The theoretical interpretation of these most promising time-lag windows is threefold; i) a magnetic flux eruption perturbs the jet-disc boundary and creates a flux tube, ii) the flux tube orbits and creates a clear emission feature, and iii) the flux tube interacts with the jet-disc boundary. The best-fitting windows have an intermediate (i=30$^\circ$/50$^\circ$) inclination and zero-BH-spin. The targeted `slow light' study did not yield better-fitting time-lag results, which indicates that the fast vs. slow light paradigm is often not intuitively understood and is likely influential in timing-sensitive studies. Sophisticated general-relativistic magnetrohydrodynamical models consistently capture the observational time-lag behavior, which is rooted in the complex dynamic interplay between the flux tube and coupled disk-jet system.
description: 19 pages, 11 figures. Accepted in A&A
Build and They Will Come: Gender Differences in Return on Investment and Quality in NCAA Division I Basketball
Creators: name: Vahid, Parisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Given the recent uptick in athletic department expenditures, revenue concerns, and the 50th anniversary of Title IX, this research focuses on basketball-specific finances across genders. We estimate the relationship between investment, the quality of a team, and revenue, with a concentration on gender differences. Following academic precedent, we use an original data set merging EADA, IPEDS, and NCAA data to estimate our results. Uniquely, principal component analysis is used, as well as quantile regression. The results indicate that increased investment and quality positively impact a team’s revenue, regardless of gender. However, the effects are not homogeneous across gender or teams of different quality. We find that a dollar spent in men’s basketball returns more revenue than in women’s basketball, but this gap shrinks as the quality of the teams improve. Thus, women’s basketball programs of low quality have the most to gain by creating quality programs so that they become more viable revenue generators.
Optogenetic Apoptosis: Light-Triggered Cell Death
Creators: name: Lamb, Kelsey N.
name: Lawrence, David S.
name: Smith, Weston J.
name: Pollet, Rebecca M.
name: Hughes, Robert M.
name: Freeman, David J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: An optogenetic Bax has been designed that facilitates light-induced apoptosis. We demonstrate that mitochondrial recruitment of a genetically encoded light-responsive Bax results in the release of mitochondrial proteins, downstream caspase 3 cleavage, changes in cellular morphology, and ultimately cell death. Mutagenesis of a key phosphorylatable residue or modification of the C-terminus mitigates background levels (dark) of apoptosis due to Bax overexpression. The mechanism of optogenetic Bax-mediated apoptosis was explored using a series of small molecules known to interfere with various steps in programmed cell death. Optogenetic Bax appears to form a mitochondrial apoptosis-induced channel analogous to that of endogenous Bax.
Kinderfeindliche Sexualität und ihr Gegenbild
Creators: name: Does De Willebois, Alexander Emile Marie Van Der
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 14 Nr. 2 (1985): Internationale katholische Zeitschrift Communio, Band 14, Heft 2
A Three-Loop Neutrino Model with Global $U(1)$ Symmetry
Creators: name: Hatanaka, Hisaki
name: Nishiwaki, Kenji
name: Okada, Hiroshi
name: Orikasa, Yuta
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study a three-loop induced neutrino model with a global $U(1)$ symmetry at TeV scale, in which we naturally accommodate a bosonic dark matter candidate. We discuss the allowed regions of masses and quartic couplings for charged scalar bosons as well as the dark matter mass on the analogy of the original Zee-Babu model, and show the difference between them. We also discuss the possibility of the collider searches, in which future like-sign electron liner collider could be promising.
description: 21 pages, 5 figures; reference added, typos corrected; version accepted for publication in Nuclear Physics B
Asymptotically free scaling solutions in nonabelian Higgs models
Creators: name: Gies, Holger
name: Zambelli, Luca
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct asymptotically free renormalization group trajectories for the generic nonabelian Higgs model in four-dimensional spacetime. These ultraviolet-complete trajectories become visible by generalizing the renormalization/boundary conditions in the definition of the correlation functions of the theory. Though they are accessible in a controlled weak-coupling analysis, these trajectories originate from threshold phenomena which are missed in a conventional perturbative analysis relying on the deep Euclidean region. We identify a candidate three-parameter family of renormalization group trajectories interconnecting the asymptotically free ultraviolet regime with a Higgs phase in the low-energy limit. We provide estimates of their low-energy properties in the light of a possible application to the standard model Higgs sector. Finally, we find a two-parameter subclass of asymptotically free Coleman-Weinberg-type trajectories that do not suffer from a naturalness problem.
description: 6 pages, 2 figures. One section added. Updated to match the published version
Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
Creators: name: Gu, Zhen
name: Hu, Quanyin
name: Beisel, Chase L.
name: Ji, Wenyan
name: Wang, Chao
name: Sun, Wujin
name: Hall, Jordan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: CRISPR-Cas9 represents a promising technology for genome editing, yet means of safe and efficient delivery remain to be fully realized. Here, we report a novel delivery vehicle to deliver the Cas9 protein and single-guide RNA simultaneously based on DNA nanoclews, yarn-like DNA nanoparticles synthesized by rolling circle amplification. The bio-inspired vehicles efficiently loaded Cas9/single-guide RNA complexes and delivered the complexes to the nuclei of human cells, allowing targeted gene disruptions while maintaining cell viability. Editing was most efficient when the DNA nanoclew sequence and the sgRNA guide sequence were partially complementary, offering a design rule for enhancing delivery. Overall, this strategy provides a versatile platform that could be adapted for delivering other DNA-binding proteins or for functional nucleic acids.
Additional file 3: of Ethnobotanical study of medicinal plants in the Hawassa Zuria District, Sidama zone, Southern Ethiopia
Creators: name: Banchiamlak Tefera
name: Young-Dong Kim
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Table S3. List of diseases and number of plant species (DOCX 18 kb)
Temperature-dependent generalized ellipsometry of the metal-insulator phase transition in low-symmetry charge-transfer salts
Creators: name: Tiwari, Achyut
name: Gompf, Bruno
name: Dressel, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Determining the optical and electronic properties of strongly anisotropic materials with symmetries below orthorhombic remains challenging; generalized ellipsometry is a powerful technique in this regard. Here, we employ Mueller matrix spectroscopic and temperature-dependent ellipsometry to determine the frequency dependence of six components of the dielectric-function tensor of the two-dimensional charge-transfer salt $α$-(BEDT-TTF)$_2$I$_3$ across its metal-insulator transition. Our results offer valuable insights into temperature-dependent changes of the components of the spectroscopic dielectric-function tensor across the metal-insulator transition. This advanced method allows extension to other electronic transitions.
Additional file 4: of Ethnobotanical study of medicinal plants in the Hawassa Zuria District, Sidama zone, Southern Ethiopia
Creators: name: Banchiamlak Tefera
name: Young-Dong Kim
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Table S4. Sociodemographic details of the respondents in the Hawassa Zuria district. (DOCX 15 kb)
Updated Catalog of Kepler Planet Candidates: Focus on Accuracy and Orbital Periods
Creators: name: Lissauer, Jack J.
name: Rowe, Jason F.
name: Jontof-Hutter, Daniel
name: Fabrycky, Daniel C.
name: Ford, Eric B.
name: Ragozzine, Darin
name: Steffen, Jason H.
name: Nizam, Kadri M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present a new catalog of Kepler planet candidates that prioritizes accuracy of planetary dispositions and properties over uniformity. This catalog contains 4376 transiting planet candidates, including 1791 residing within 709 multi-planet systems, and provides the best parameters available for a large sample of Kepler planet candidates. We also provide a second set of stellar and planetary properties for transiting candidates that are uniformly-derived for use in occurrence rates studies. Estimates of orbital periods have been improved, but as in previous catalogs, our tabulated values for period uncertainties do not fully account for transit timing variations (TTVs). We show that many planets are likely to have TTVs with long periodicities caused by various processes, including orbital precession, and that such TTVs imply that ephemerides of Kepler planets are not as accurate on multi-decadal timescales as predicted by the small formal errors (typically 1 part in $10^6$ and rarely $ > 10^{-5}$) in the planets' measured mean orbital periods during the Kepler epoch. Analysis of normalized transit durations implies that eccentricities of planets are anti-correlated with the number of companion transiting planets. Our primary catalog lists all known Kepler planet candidates that orbit and transit only one star; for completeness, we also provide an abbreviated listing of the properties of the two dozen non-transiting planets that have been identified around stars that host transiting planets discovered by Kepler.
description: 62 pages, 32 figures, 5 tables. Published in The Planetary Science Journal, volume 5, #6 (2024). The first table appears in abbreviated form in the main manuscript and is provided in full as a separate file. A standard resolution version of Figure 32 appears within the manuscript; a high-resolution version of Figure 32 is also provided separate file
The effects of development and temperature on immunity in Manduca sexta
Creators: name: Williams, Madison
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Both immunity and development are temperature-dependent, but how development and temperature interact to affect immunity has yet to be explored. Here we measure immunity changes during the 4th instar in Manduca sexta larvae under low (18°C), control (25°C), and high (32°C) temperatures. Different immune pathways differed in their responses across development, with the melanization immune response increasing over the course of the instar. Melanization also differed from the control temperature at high, but not low temperatures. There was no significant relationship found between immunity and development or temperature for the encapsulation immune pathway. These results suggest immunity in insects may be weakened as climate change increases the frequency and intensity of extreme heat events as well as average temperatures.
Observation of $e^+e^-\to χ_{c0}ω$ and missing higher charmonium $ψ(4S)$
Creators: name: Chen, Dian-Yong
name: Liu, Xiang
name: Matsuki, Takayuki
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Stimulated by the recent BESIII observation of a new resonance in $e^+ e^- \to ωχ_{c0}$ and by the fact that this state is consistent with our predicted $ψ(4S)$, in this work we estimate the meson loop contribution to $ψ(4S) \to ωχ_{c0}$. The evaluation indicates that our theoretical estimate can overlap with the experimental data in a reasonable parameter range. This fact shows that introduction of the missing higher charmonium $ψ(4S)$ provides a possible explanation to the recent BESIII observation. The upper limit of a branching ratio of $ψ(4S) \to ηJ/ψ$ is also predicted as $1.9 \times 10^{-3}$, which can be further tested by BESIII, Belle and forthcoming BelleII.
description: 8 pages, 6 figures and 2 tables. More discussions added. Accepted by PRD
The Joke is On Us: An Analysis of the Purpose and Techniques of Eighteenth- and Twenty-First Century Western Satire
Creators: name: Elizabeth Leonard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: The eighteenth century is known as the Golden Age of Satire for Western civilization, and the twenty-first century has produced great satirical works as well, leading to speculation that the modern era may be a new Golden Age of Satire. This thesis analyzes popular satires produced in both centuries by comparing similar satirical works in three distinct chapters. The first chapter compares Jonathan Swift's novel, Gulliver's Travels, with Stephen Colbert's television program, the Colbert Report, in order to address the political developments within the satire genre, and how they influence these satires. The second chapter compares Alexander Pope's mock-epic The Dunciad, with Sacha Baron Cohen's 2006 film Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan, in order to analyze the influence of established artistic structure and Western cultural opinion on eighteenth- and twenty-first century satires. Finally, the third chapter compares Charlotte Lennox's novel The Female Quixote with damali ayo's book and website, both titled How to Rent a Negro, in order to investigate how satires written by marginalized communities influence Western satire in these two centuries, and how they are accepted in the wider satirical world.
Evolution of linear perturbations in Lemaître-Tolman-Bondi void models
Creators: name: Meyer, Sven
name: Redlich, Matthias
name: Bartelmann, Matthias
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the evolution of linear perturbations in a Lemaître-Tolman-Bondi (LTB) void model with realistic cosmological initial conditions. Linear perturbation theory in LTB models is substantially more complicated than in standard Friedmann universes as the inhomogeneous background causes gauge-invariant perturbations to couple at first order. As shown by Clarkson et al. (2009), the evolution is constrained by a system of linear partial differential equations which need to be integrated numerically. We present a new numerical scheme using finite element methods to solve this equation system and generate scalar initial conditions based on Gaussian random fields with an underlying power spectrum for the Bardeen potential. After spherical harmonic decomposition, the initial fluctuations are propagated in time and estimates of angular power spectra of each gauge invariant variable are computed as functions of redshift. This allows to analyse the coupling strength in a statistical way. We find significant couplings up to $25\%$ for large and deep voids of Gpc scale as required to fit the distance redshift relations of SNe.
description: 39 pages, typos corrected, accepted for publication in JCAP
Ly$α$NNA: A Deep Learning Field-level Inference Machine for the Lyman-$α$ Forest
Creators: name: Nayak, Parth
name: Walther, Michael
name: Gruen, Daniel
name: Adiraju, Sreyas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The inference of astrophysical and cosmological properties from the Lyman-$α$ forest conventionally relies on summary statistics of the transmission field that carry useful but limited information. We present a deep learning framework for inference from the Lyman-$α$ forest at field-level. This framework consists of a 1D residual convolutional neural network (ResNet) that extracts spectral features and performs regression on thermal parameters of the IGM that characterize the power-law temperature-density relation. We train this supervised machinery using a large set of mock absorption spectra from Nyx hydrodynamic simulations at $z=2.2$ with a range of thermal parameter combinations (labels). We employ Bayesian optimization to find an optimal set of hyperparameters for our network, and then employ a committee of 20 neural networks for increased statistical robustness of the network inference. In addition to the parameter point predictions, our machine also provides a self-consistent estimate of their covariance matrix with which we construct a pipeline for inferring the posterior distribution of the parameters. We compare the results of our framework with the traditional summary (PDF and power spectrum of transmission) based approach in terms of the area of the 68% credibility regions as our figure of merit (FoM). In our study of the information content of perfect (noise- and systematics-free) Ly$α$ forest spectral data-sets, we find a significant tightening of the posterior constraints -- factors of 10.92 and 3.30 in FoM over power spectrum only and jointly with PDF, respectively -- that is the consequence of recovering the relevant parts of information that are not carried by the classical summary statistics.
description: 15 pages, 16 figures, to be published in Astronomy and Astrophysics. This update contains the peer-reviewd, accepted version of the paper
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis
Creators: name: Wagner, Marek
name: Bjerkvig, Rolf
name: Wiig, Helge
name: Lin, Ruei-Zeng
name: Klagsbrun, Michael
name: Melero-Martin, Juan M.
name: Dudley, Andrew C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Tumor-associated stroma is typified by a persistent, non-resolving inflammatory response that enhances tumor angiogenesis, growth and metastasis. Inflammation in tumors is instigated by heterotypic interactions between malignant tumor cells, vascular endothelium, fibroblasts, immune and inflammatory cells. We found that tumor-associated adipocytes also contribute to inflammation. We have analyzed peritumoral adipose tissue in a syngeneic mouse melanoma model. Compared to control adipose tissue, adipose tissue juxtaposed to implanted tumors exhibited reduced adipocyte size, extensive fibrosis, increased angiogenesis and a dense macrophage infiltrate. A mouse cytokine protein array revealed up-regulation of inflammatory mediators including IL-6, CXCL1, MCP-1, MIP-2 and TIMP-1 in peritumoral versus counterpart adipose tissues. CD11b+ macrophages contributed strongly to the inflammatory activity. These macrophages were isolated from peritumoral adipose tissue and found to overexpress ARG1, NOS2, CD301, CD163, MCP-1 and VEGF, which are indicative of both M1 and M2 polarization. Tumors implanted at a site distant from subcutaneous, anterior adipose tissue were strongly growth-delayed, had fewer blood vessels and were less populated by CD11b+ macrophages. In contrast to normal adipose tissue, micro-dissected peritumoral adipose tissue explants launched numerous vascular sprouts when cultured in an ex vivo model. Thus, inflamed tumor-associated adipose tissue fuels the growth of malignant cells by acting as a proximate source for vascular endothelium and activated pro-inflammatory cells, in particular macrophages.
Identification of a stable molecular signature in mammary tumor endothelial cells that persists in vitro
Creators: name: Perou, Charles M.
name: Dudley, Andrew C.
name: Harrell, J. Chuck
name: Xiao, Lin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Long-term, in vitro propagation of tumor-specific endothelial cells (TEC) allows for functional studies and genome-wide expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically engineered mouse model (GEMM) of mammary adenocarcinoma, we have optimized an isolation procedure and defined growth conditions for long-term propagation of mammary TEC. The isolated TEC maintain their endothelial specification and phenotype in culture. Furthermore, gene expression profiling of multiple TEC subpopulations revealed striking, persistent overexpression of several candidate genes including Irx2 and Zfp503 (transcription factors), Alcam and Cd133 (cell surface markers), Ccl4 and neurotensin (Nts) (angiocrine factors), and Gpr182 and Cnr2 (G protein-coupled receptors, GPCRs). Taken together, we have developed an effective method for isolating and culture-expanding mammary TEC, and uncovered several new TEC-selective genes whose overexpression persists even after long-term in vitro culture. These results suggest that the tumor microenvironment may induce changes in vascular endothelium in vivo that are stably transmittable in vitro.