cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multivariate Longitudinal Shape Analysis of Human Lateral Ventricles during the First Twenty-Four Months of Life
Creators: name: Bompard, Lucile
name: Ahn, Mihye
name: Xu, Shun
name: Styner, Martin
name: Yuan, Ying
name: Shen, Dinggang
name: Paniagua, Beatriz
name: Lin, Weili
name: Zhu, Hongtu
name: Jewells, Valerie
name: Gao, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundLittle is known about the temporospatial shape characteristics of human lateral ventricles (LVs) during the first two years of life. This study aimed to delineate the morphological growth characteristics of LVs during early infancy using longitudinally acquired MR images in normal healthy infants.Methods24 healthy infants were MR imaged starting from 2 weeks old every 3 months during the first and every 6 months during the second year. Bilateral LVs were segmented and longitudinal morphological and shape analysis were conducted using longitudinal mixed effect models.ResultsA significant bilateral ventricular volume increase (p<0.0001) is observed in year one (Left: 126±51% and Right: 145±62%), followed by a significant reduction (p<0.02) during the second year of life (Left: −24±27% and Right: −20±18%) despite the continuing increase of intracranial volume. Morphological analysis reveals that the ventricular growth is spatially non-uniform, and that the most significant growth occurs during the first 6 months. The first 3 months of life exhibit a significant (p<0.01) bilateral lengthening of the anterior lateral ventricle and a significant increase of radius (p<0.01) and area (p<0.01) at the posterior portion of the ventricle. Shape analysis shows that the horns exhibit a faster growth rate than the mid-body. Finally, bilateral significant age effects (p<0.01) are observed for the growth of LVs whereas gender effects are more subtle and significant effects (p<0.01) only present at the left anterior and posterior horns. More importantly, both the age and gender effects are growth directionally dependent.ConclusionsWe have demonstrated the temporospatial shape growth characteristics of human LVs during the first two years of life using a unique longitudinal MR data set. A temporally and spatially non-uniform growth pattern was reported. These normative results could provide invaluable information to discern abnormal growth patterns in patients with neurodevelopmental disorders.
Polynomial approximation with doubling weights having finitely many zeros and singularities
Creators: name: Kopotun, Kirill A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: We prove matching direct and inverse theorems for (algebraic) polynomial approximation with doubling weights $w$ having finitely many zeros and singularities (i.e., points where $w$ becomes infinite) on an interval and not too ``rapidly changing'' away from these zeros and singularities. This class of doubling weights is rather wide and, in particular, includes the classical Jacobi weights, generalized Jacobi weights and generalized Ditzian-Totik weights. We approximate in the weighted $L_p$ (quasi) norm $\|f\|_{p, w}$ with $0
MIGNEX Case Study Brief PAK1 - Migration and development dynamics in Chot Dheeran, Pakistan
Creators: name: Erdal, Marta Bivand
name: Khan, Furrukh
name: Ahmad, Arslan
name: Safia, Mahmoud
name: Hannah, Murray
Publisher: name: Peace Research Institute Oslo
Year: 2022

description: Transnational ties are strong in Chot Dheeran, where international out-migration shapes local development. Yet the impacts of migration often reflect socio-economic disparity and perceptions are mixed.

Key Takeaways

International out-migration – largely to Europe – shapes ideas about the future, livelihoods, standards of wealth, ambition and life satisfaction.

Very few legal pathways to Europe mean that most migrate irregularly. Nearly one in five young adults (18%) have experienced a failed migration attempt.

Some 38% of young men do not think that they will be living in Chot Dheeran in five years – and almost all of these men (94%) do not expect to be in Pakistan.
Eurasian economic Union integration as adaptation effect in agro-food trade
Creators: name: Siptits Stanislav Ottovich
name: Romanenko Irina Anatolyevna
name: Evdokimova Natalia Egorovna
Publisher: name: International   Agricultural   Journal
Year: 2018
Subjects: Eurasian Economic Union
integration
adaptation
forecast
trade
agriculture

description: The paper is devoted to the analysis of agro-food trade development prospects and problems in Eurasian Economic Union (EAEU) of Russia, Kazakhstan, Belarus and Armenia. It suggests the method for estimation of integration processes in the trade of agricultural and food products. The article gives the scenario forecasts for export of meat, milk, grains, oilseeds, vegetable oils, sugar from EAEC member states. Evaluation of the integration effect is made on the difference between the forecasts and inertial integration scenarios.
Förderung der emotionalen Kompetenzen bei Kindern mit kognitiver Beeinträchtigung. Eine Analyse des Lehrmittels FesK nach emotionalen Voraussetzungen und Aneignungsmöglichkeiten
Creators: name: Dudli, Yvonne
Publisher: name: Zenodo
Year: 2022
Subjects: Sonderpädagogik
Masterarbeit
kognitive Beeinträchtigung
FesK

description: Diese Arbeit befasst sich mit der Frage, inwiefern das Lehrmittel FesK (Förderung emotional-sozialer Kompetenzen)den Schüler*innen mit einer kognitiven Beeinträchtigung entspricht. Fördern die Inhalte die emotionale Entwicklungsphase 3 der Ersten Individuation? Bei der Unterrichtsmethodik wird analysiert, ob sie für das konkret-gegenständliche Aneignungsniveaugeeignet ist. Anhand der qualitativen Inhaltsanalyse werden die Daten ausgewertet. Die Kategorien werden durch das Phasenmodell der emotionalen Entwicklung von Sappok und Zepperitz (2019) und durch die Beschreibung der Aneignungsmöglichkeiten nach Dietrich (2019) hergeleitet. Es kann festgestellt werden, dass FesK verwendbare Inhalte zur Förderung der emotionalen Kompetenzen enthält. Die Methodik wird höher als für das konkret-gegenständliche Aneignungsniveau eingeschätzt. Ein Ideenkatalog wird angeboten, um die Erkenntnisse aus dieser Arbeit für die Praxis zu nutzen und den schulischen Alltag an einer Heilpädagogischen Schule zu unterstützen.
Agricultural innovation clusters in Canada
Creators: name: Grigorieva Elena
name: Shulga Pavel
Publisher: name: International   Agricultural   Journal
Year: 2018
Subjects: Canada
agriculture
regional innovation clusters
sectoral innovation clusters
superclusters

description: The article analyses the current Сanadian system of agricultural innovation clusters. It examines the regional and sectoral clusters. Special attention is paid to the new national project to create innovative superclusters in Canada.
Muscle RING Finger-1 Promotes a Maladaptive Phenotype in Chronic Hypoxia-Induced Right Ventricular Remodeling
Creators: name: Hoppin, Jack
name: Lucas, Selita N.
name: Norenberg, Jeffrey P.
name: Nysus, Monique
name: Campen, Matthew J.
name: Gershman, Ben
name: Willis, Monte
name: Hesterman, Jacob
name: Paffett, Michael L.
name: Anderson, Tamara
name: Colombo, E. Sage
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left ventricular hypertrophy and altered cardiac bioenergetics in pressure overloaded hearts. However, little is known about the contribution of MuRF1 impacting RVH in the setting of CH. Therefore, we hypothesized that MuRF1 deletion would enhance RVH compared to their wild-type littermates, while cardiac-specific overexpression would reduce hypertrophy following CH-induced pulmonary hypertension. We assessed right ventricular systolic pressure (RVSP), right ventricle to left ventricle plus septal weight ratio (RV/LV+S) and hematocrit (Hct) following a 3-wk isobaric CH exposure. Additionally, we conducted dual-isotope SPECT/CT imaging with cardiac function agent 201Tl-chloride and cell death agent 99mTc-annexin V. Predictably, CH induced pulmonary hypertension, measured by increased RVSP, RV/LV+S and Hct in WT mice compared to normoxic WT mice. Normoxic WT and MuRF1-null mice exhibited no significant differences in RVSP, RV/LV+S or Hct. CH-induced increases in RVSP were also similar between WT and MuRF1-null mice; however, RV/LV+S and Hct were significantly elevated in CH-exposed MuRF1-null mice compared to WT. In cardiac-specific MuRF1 overexpressing mice, RV/LV+S increased significantly due to CH exposure, even greater than in WT mice. This remodeling appeared eccentric, maladaptive and led to reduced systemic perfusion. In conclusion, these results are consistent with an atrophic role for MuRF1 regulating the magnitude of right ventricular hypertrophy following CH-induction of pulmonary hypertension.
Development of tourism in the Nizhny Novgorod region
Creators: name: Nuzhdina, Marina V.
Publisher: name: International   Agricultural   Journal
Year: 2018
Subjects: tourism
tourist products
tourist resources
tourist complexes

description: In recent years, one of the most actively developing areas of activity has become the sphere of service and tourism. Consumption of services begins to prevail over the consumption of material goods. The sphere of service and tourism is a dynamically developing area of public relations and a significant branch of the modern economy. At present, tourism is the most promising branch of the world economy, an important area that has a certain impact on the development of the country's economy, including the development of economic activities: travel companies, trade, communications, collective accommodation facilities, souvenir production, food, agriculture, construction.
OPERAS Open Chats: Wir müssen reden... heute über geisteswissenschaftliche Publikationen und Editionen
Creators: name: Pattrick Piel
name: Hensen, Kilian
name: Schulz, Daniela
Publisher: name: Zenodo
Year: 2022
Subjects: OPERAS
OPERAS-GER
SSH
Humanities and Social Sciences
Text+

description: Presentation of the event on the OPERAS Infrastructure held by OPERAS-GER on 15 September 2022.
Natural Aminoacyl tRNA Synthetase Fragment Enhances Cardiac Function after Myocardial Infarction
Creators: name: Moser-Katz, Tyler
name: Rojas, Mauricio
name: Reader, John S.
name: Tzima, Ellie
name: McCormick, Margaret E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to ‘moonlight’ as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines have previously been proposed to be promising therapeutic mechanisms for the treatment of myocardial infarction. Here, we show that systemic delivery of the natural fragment of TyRS, mini-TyrRS, improves heart function in mice after myocardial infarction. This improvement is associated with reduced formation of scar tissue, increased angiogenesis of cardiac capillaries, recruitment of c-kitpos cells and proliferation of myocardial fibroblasts. This work demonstrates that mini-TyrRS has beneficial effects on cardiac repair and regeneration and offers support for the notion that elucidation of the ever expanding repertoire of noncanonical functions of aminoacyl tRNA synthetases offers unique opportunities for development of novel therapeutics.
NIMH Project Accept (HPTN 043): Results from In-Depth Interviews with a Longitudinal Cohort of Community Members
Creators: name: Muravha, Tshifhiwa
name: Phakathi, Zipho
name: F.Morin, Stephen
name: van Rooyen, Heidi
name: Maman, Suzanne
name: Srirak, Namtip
name: Chingono, Alfred
name: Ntogwisangu, Jacob
name: Stankard, Petra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: IntroductionNIMH Project Accept (HPTN 043) is a community- randomized trial to test the safety and efficacy of a community-level intervention designed to increase testing and lower HIV incidence in Tanzania, Zimbabwe, South Africa and Thailand. The evaluation design included a longitudinal study with community members to assess attitudinal and behavioral changes in study outcomes including HIV testing norms, HIV-related discussions, and HIV-related stigma.MethodsA cohort of 657 individuals across all sites was selected to participate in a qualitative study that involved 4 interviews during the study period. Baseline and 30-month data were summarized according to each outcome, and a qualitative assessment of changes was made at the community level over time.ResultsMembers from intervention communities described fewer barriers and greater motivation for testing than those from comparison communities. HIV-related discussions in intervention communities were more grounded in personal testing experiences. A change in HIV-related stigma over time was most pronounced in Tanzania and Zimbabwe. Participants in the intervention communities from these two sites attributed community-level changes in attitudes to project specific activities.DiscussionThe Project Accept intervention was associated with more favorable social norms regarding HIV testing, more personal content in HIV discussions in all study sites, and qualitative changes in HIV-related stigma in two of five sites.
Co-existence of states in quantum systems
Creators: name: Iwata, Yoritaka
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Nuclear Theory (nucl-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Co-existence of different states is a profound concept, which possibly underlies the phase transition and the symmetry breaking. Because of a property inherent to quantum mechanics (cf. uncertainty), the co-existence is expected to appear more naturally in quantum-microscopic systems than in macroscopic systems. In this paper a mathematical theory describing co-existence of states in quantum systems is presented, and the co-existence is classified into 9 types.
description: To appear in J. Phys.: Conf. Ser. (SOTANCP3)
Selection of oil flax in Siberian experimental station
Creators: name: Suleimenova Aigera Kenzhebaevna
Publisher: name: International   Agricultural   Journal
Year: 2018
Subjects: flax oil seed
selection
variety
productivity
oil content
stability to fusarium

description: The article presents the results of selection in the flax oil seed Siberian Experimental Station (Omsk region, Russia) VNIIMK. Selection work on flax oil seed in the Station conducted since 1961, the main direction the creation of highly productive mid-seasonvarieties with high oil content in the seeds of good quality, stability to fusarium, sloughing and lodging. Breeder's laboratory for this period created and regionalized 5 flax varieties: Isil'kul'skiy, Legur, Severnyy, Sokol, Avgust. Since 2016 the State variety testing takes new highly productive early maturing, highly stable to fusarium variety of oil flax Sapfir. Also, one of the promising areas of of oil flax breeding creation low linolenic varieties for use for food purposes. In the process selection of oil flax highly varieties sample created, with a high stability to fusarium having of linolenic acid content in the oil 1,32-31,53%. Each year, a new material that passes a rigorous selection.
Openness assessment of 132 open source hardware products
Creators: name: Bonvoisin, Jérémy
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 600 Technik, Technologie
subject: open source hardware
subject: open design
subject: open source product development
subject: open innovation
subject: open source innovation
subject: openness

description: This is the raw data set on which the article "What is the source of open source hardware?" to be published in the Journal of Open Hardware under an open access license is based. The abstract of the article is as follows: "What “open source” means once applied to tangible products has been so far exclusively addressed through the light of licensing. While this approach is adapted for software, it appears to be over-simplistic for complex hardware products. Whether such a product can be labelled as open source is not only a question of license but also a question of documentation, i.e. what is the information that sufficiently describes it? In other words, what is the “source” of open source hardware? To date there is no trivial answer to this question, leaving large room for interpretation in the usage of the term. Based on analysis of public documentation of 132 products, this paper provides an overview of how practitioners tend to interpret the concept of open source hardware. Results empirically confirm the existence of two main usages of the open source principles in the context of tangible products: publication of product-related documentation as a means to support community-based product development and to disseminate privately developed innovations. It also underlines the high variety of interpretations and even misuses of the concept of open source hardware. This reveals in turn that this concept may not even be clear to practitioners and calls for more narrowed down definitions of what has to be shared for a product to be called open source. Results gained by the analysis of current publication practice are summarized in the definition of an open source hardware lifecycle to contribute towards this effort."
Messdaten zum Honigmann-Prozess
Creators: name: Jahnke, Anna
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 620 Ingenieurwissenschaften
subject: Honigmann
subject: thermochemische Energiespeicherung
subject: Sorptionstechnik
subject: thermochemical energy storage
subject: sorption

description: Bei den beiliegenden Dateien handelt es sich um Messdaten zu Versuchen zum Honigmann-Prozess. Informationen zur Entstehung der Messwerte und deren Analyse finden sich in der dazugehörigen Dissertation "Untersuchung des Honigmann-Prozesses zur thermochemischen Energiespeicherung"
Human hand grasping experiments: annotated grasps segments
Creators: name: Heinemann, Fabian
name: Puhlmann, Steffen
name: Eppner, Clemens
name: Álvarez-Ruiz, José
name: Meartens, Marianne
name: Brock, Oliver
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: Grasping
subject: Human studies

description: This dataset contains segmented labelling data from human hand grasping experiments. The human experiment data was labelled by 3 independent labellers.
Descriptions of new species of hymenopterous insects collected by Mr. A. R. Wallace at Celebes. (Part Formicidae)
Creators: name: Smith, F.
Publisher: name: Zenodo
Year: 1860
Subjects: Biodiversity
Taxonomy

description: 1. Formica smaragdina, Fabr. Spec. Ins. p. 488 ☿. Hab. Celebes; Borneo; Malacca; Sumatra; Philippine Islands.
description: Published as part of Smith, F., 1860, Descriptions of new species of hymenopterous insects collected by Mr. A. R. Wallace at Celebes. (Part Formicidae), pp. 57-93 in Journal of the Proceedings of the Linnean Society of London, Zoology 5 on page 68
NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells
Creators: name: Lee, Kuo-Hsiung
name: Pan, Shiow-Lin
name: Chen, Mei-Chuan
name: Wu, Szu-Ying
name: Hsu, Jui-Ling
name: Teng, Che-Ming
name: Xiao, Zhi-Yan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: NPRL-Z-1 is a 4β-[(4″-benzamido)-amino]-4′-O-demethyl-epipodophyllotoxin derivative. Previous reports have shown that NPRL-Z-1 possesses anticancer activity. Here NPRL-Z-1 displayed cytotoxic effects against four human cancer cell lines (HCT 116, A549, ACHN, and A498) and exhibited potent activity in A498 human renal carcinoma cells, with an IC50 value of 2.38 µM via the MTT assay. We also found that NPRL-Z-1 induced cell cycle arrest in G1-phase and detected DNA double-strand breaks in A498 cells. NPRL-Z-1 induced ataxia telangiectasia-mutated (ATM) protein kinase phosphorylation at serine 1981, leading to the activation of DNA damage signaling pathways, including Chk2, histone H2AX, and p53/p21. By ICE assay, the data suggested that NPRL-Z-1 acted on and stabilized the topoisomerase II (TOP2)–DNA complex, leading to TOP2cc formation. NPRL-Z-1-induced DNA damage signaling and apoptotic death was also reversed by TOP2α or TOP2β knockdown. In addition, NPRL-Z-1 inhibited the Akt signaling pathway and induced reactive oxygen species (ROS) generation. These results demonstrated that NPRL-Z-1 appeared to be a novel TOP2 poison and ROS generator. Thus, NPRL-Z-1 may present a significant potential anticancer candidate against renal carcinoma.
Transition bei Mehrfachbehinderung. Wie Eltern von Kindern mit Mehrfachbehinderung den Übergang von der Familie in den Kindergarten bewältigen
Creators: name: Limacher, Daniela
Publisher: name: Zenodo
Year: 2022
Subjects: Sonderpädagogik
Masterarbeit
Mehrfachbehinderung
Transition
Kindergarten

description: Die erfolgreiche Bewältigung von biografischen Übergängen tragen massgeblich zu einer günstigen Entwicklung und dem erfolgreichen Umgang mit zukünftigen Übergängen bei. Eine Aufgabe der Heilpädagogischen Früherziehung (HFE) ist die Begleitung von Kindern und ihren Eltern bei Übergängen. Die vorliegende Arbeit untersucht, wie Eltern eines Kindes mit Mehrfachbehinderung den Übergang in die erste Bildungseinrichtung bewältigen. Die inhaltsanalytische Auswertung von qualitativen Interviews zeigt auf, dass es sich um ein erwünschtes Ereignis, verbunden mit positiven Erwartungen handelt. Weiter konnten besondere Herausforderungen abgeleitet und günstige Bewältigungsfaktoren auf der individuellen, familiären und professionellen Ebene aufgezeigt werden. Die HFE nimmt eine prozessbegleitende Rolle ein. Für die Praxis der HFE lassen sich Erkenntnisse in Bezug auf die Beratung und Begleitung der Eltern ableiten. Schlüsse für die interdisziplinäre Arbeit und Kooperation bleiben weitest-gehend offen.
Software and Mobile Apps to support the clinical diagnosis of Hansen's Disease: a scoping review
Creators: name: Frade, Marco Andrey Cipriani
name: De Oliveira, Alan Maicon
name: Luiz Ricardo Albano Dos Santos
name: Foresto, Felipe
name: Santos, Luana Michelly Aparecida Costa Dos
name: Costa, Wilbert Dener Lemos
name: Aguilar, Guilherme José
name: Dantony De Castro Barros Donato
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Computer Sciences
subject: Public Health Education and Promotion
subject: Computer Engineering
subject: Educational Assessment, Evaluation, and Research
subject: Bacterial Infections and Mycoses
subject: Medical Education
subject: Engineering
subject: Physical Sciences and Mathematics
subject: Health Information Technology
subject: Digital Communications and Networking
subject: Education
subject: Public Health
subject: Life Sciences
subject: Interprofessional Education
subject: Diseases
subject: Medicine and Health Sciences

description: This scoping review aims to identify the studies published in the scientific literature of software and mobile applications aimed at supporting the clinical diagnosis of leprosy cases, as well as how to describe their main characteristics.
Spin glass like ground state and observation of exchange bias in Mn_{0.8}Fe_{0.2}NiGe alloy
Creators: name: Dutta, P.
name: Pramanick, S.
name: Venkateshwarlu, D.
name: Ganesan, V.
name: Majumdar, S.
name: Das, D.
name: Chatterjee, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The ground-state magnetic properties of hexagonal equiatomic alloy of nominal composition Mn_{0.8}Fe_{0.2}NiGe were investigated through dc magnetization and heat capacity measurements. The alloy undergoes first order martensitic transition below 140 K with simultaneous development of long range ferromagnetic ordering from the high temperature paramagnetic phase. The undoped compound MnNiGe has an antiferromagnetic ground state and it shows martensitic like structural instability well above room temperature. Fe doping at the Mn site not only brings down the martensitic transition temperature, it also induces ferromagnetism in the sample. Our study brings out two important aspects regarding the sample, namley (i) the observation of exchange bias at low temperature, and (ii) spin glass like ground state which prevails below the martensitic and magnetic transition points. In addition to the observed usual relaxation behavior the spin glass state is confirmed by zero field cooled memory experiment, thereby indicating cooperative freezing of spin and/or spin clusters rather than uncorrelated dynamics of superparamagnetic like spin clusters. We believe that doping disorder can give rise to some islands of antiferromagnetic clusters in the otherwise ferromagnetic background which can produce interfacial frustration and exchange pinning responsible for spin glass and exchange bias effect. A comparison is made with doped rare-earth manganites where similar phase separation can lead to glassy ground state.
description: Accepted for Publication in Europhysics Letters
Development and implementation of early detection tools and effective management strategies for invasive non-European and other selected fruit fly species of economic importance (FLY DETECT)
Creators: name: Milonas, Panagiotis
Publisher: name: Zenodo
Year: 2016
Subjects: Euphresco, plant health, distribution, diagnostics, management, biology, fruit fly

description: Slide of the Euphresco project 2015-E-156 'Development and implementation of early detection tools and effective management strategies for invasive non-European and other selected fruit fly species of economic importance' (FLY DETECT)
description: Project funded through the Euphresco network
Obesity-Mediated Regulation of HGF/c-Met Is Associated with Reduced Basal-Like Breast Cancer Latency in Parous Mice
Creators: name: Bendt, Katharine M.
name: McNaughton, Kirk K.
name: Troester, Melissa A.
name: Freemerman, Alex J.
name: Makowski, Liza
name: Darr, David B.
name: Sundaram, Sneha
name: Galanko, Joseph A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: It is widely thought that pregnancy reduces breast cancer risk, but this lacks consideration of breast cancer subtypes. While a full term pregnancy reduces risk for estrogen receptor positive (ER+) and luminal breast cancers, parity is associated with increased risk of basal-like breast cancer (BBC) subtype. Basal-like subtypes represent less than 10% of breast cancers and are highly aggressive, affecting primarily young, African American women. Our previous work demonstrated that high fat diet-induced obesity in nulliparous mice significantly blunted latency in C3(1)-TAg mice, a model of BBC, potentially through the hepatocyte growth factor (HGF)/c-Met oncogenic pathway. Experimental studies have examined parity and obesity individually, but to date, the joint effects of parity and obesity have not been studied. We investigated the role of obesity in parous mice on BBC. Parity alone dramatically blunted tumor latency compared to nulliparous controls with no effects on tumor number or growth, while obesity had only a minor role in further reducing latency. Obesity-associated metabolic mediators and hormones such as insulin, estrogen, and progesterone were not significantly regulated by obesity. Plasma IL-6 was also significantly elevated by obesity in parous mice. We have previously reported a potential role for stromal-derived hepatocyte growth factor (HGF) via its cognate receptor c-Met in the etiology of obesity-induced BBC tumor onset and in both human and murine primary coculture models of BBC-aggressiveness. Obesity-associated c-Met concentrations were 2.5-fold greater in normal mammary glands of parous mice. Taken together, our studies demonstrate that, parity in C3(1)-TAg mice dramatically reduced BBC latency compared to nulliparous mice. In parous mice, c-Met is regulated by obesity in unaffected mammary gland and is associated with tumor onset. C3(1)-TAg mice recapitulate epidemiologic findings such that parity drives increased BBC risk and potential microenvironmental alterations in c-Met signaling may play a role in etiology.
Polynomial Chaotic Inflation in Supergravity Revisited
Creators: name: Nakayama, Kazunori
name: Takahashi, Fuminobu
name: Yanagida, Tsutomu T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit a polynomial chaotic inflation model in supergravity which we proposed soon after the Planck first data release. Recently some issues have been raised in Ref.[12], concerning the validity of our polynomial chaotic inflation model. We study the inflaton dynamics in detail, and confirm that the inflaton potential is very well approximated by a polynomial potential for the parameters of our interest in any practical sense, and in particular, the spectral index and the tensor-to-scalar ratio can be estimated by single-field approximation. This justifies our analysis of the polynomial chaotic inflation in supergravity.
description: 13 pages, 6 figures
MIGNEX Case Study Brief NGA3 – Migration and development dynamics in Ekpoma, Nigeria
Creators: name: Aghedo, Iro
name: Oghale Diagboya, Precious
name: Binat Sarwar, Moizza
name: Hagen-Zanker, Jessica
Publisher: name: Peace Research Institute Oslo
Year: 2022

description: Ekpoma is a town in Edo State, known nationally for its university and education institutions. Given high outflows of migration in the State, migration interventions and campaigns are salient in Ekpoma.

Key Takeaways

International migration is common, with individual or collective migrant investment contributing to the prestige associated with migration.

Migration aspirations are near universal; for instance, the large majority of 18–39-year-olds (92%) would migrate to a richer country if given the necessary papers.

Return migration in Ekpoma is prominent but varied. Some return through official routes and reintegration programmes from Libya or Europe.
A value of information framework for quantifying the value of reliability assessment for a steel railway truss bridge
Creators: name: Khan, Mohammad Shihabuddin
name: Caprani, Colin
Publisher: name: Zenodo
Year: 2023

description: Presentation for Khan, Mohammad Shihabuddin, and Colin Caprani. "A Value of Information Framework for Quantifying the Value of Reliability Assessment for a Steel Railway Truss Bridge." Dublin, Ireland: Trinity College Dublin, 2023. http://www.tara.tcd.ie/handle/2262/103356.
title: The Death of a Son An Autoethnographical Journal
Creators: name: Loftus, I
Publisher: name: Liverpool John Moores University
Year: 2024

description: Does Self-Expressive Writing Help to Overcome Grief? This thesis is about the death of my son, Dominic. It is written as an autoethnographical study, and, as the story that follows his death, it is grief driven. As an integrated creative– critical academic work, the thesis examines the extent to which writing produced as we grieve is therapeutic or, as Walters suggests in A New Model of Grief: Bereavement and Biography (1996), can be a lasting memorial for the deceased. This thesis is my creative response to Walter’s biographical question and in it I’ve termed my memories of Dominic ‘our literary DNA’. In writing the thesis, I searched for connections between bereavement, creativity and mental health. I researched a range of sources, underpinning Dom’s story with my own ruminations on him and his death. Interwoven through this narrative are discussions and analysis of the grief memoirs of other writers, including Helen MacDonald’s H is For Hawk (2014), Julian Barnes’s Levels of Life (2013), George Saunders’s Lincoln in the Bardo (2017), Joan Didion’s The Year of Magical Thinking (2005), and Max Porter’s Grief is the Thing with Feathers (2015). I also investigated an earlier memoir, the seminal work of CS Lewis, A Grief Observed (1961). In their grief memoirs, writers such as Barnes and Saunders incorporate the factual, the philosophical and the fictional. Is this linked to Walter’s theory in A New Model of Grief (1996) of the grieving person creating a new narrative for the deceased? More importantly, can these works be linked to Worden’s ‘tasks’ (2011), particularly the fourth one, ‘To find an enduring connection with the deceased while embarking on a new life’? In examining these texts and the work of eminent philosophers and psychologists, I posed three questions: Why do grieving authors ultimately write about themselves as survivors of the story they are living (Jones, 2013, p. 10)? What compels the bereft to write about their loved one in creative and imaginative ways? Is a grief memoir ultimately about the author, the deceased, or both? My answers to these questions form the basis of the new knowledge of grief that underpins the critical element of my memoir narrative. My research also drew on models of bereavement counselling that regularly represent grief as progressing through different stages, each with its own set of emotions. These include Kübler-Ross’s work On Death and Dying (1969), which defines the five stages of grief after a death. My research also examined contemporary cultural expressions of grief such as those found in rap songs. I asked what it is we are searching for in songs, poetry or stories that act as a balm to our misery. And I conclude that we search for meaning in everything, including the impossibility of answering the question.
Tree Borers: risk assessment, risk management and preparedness for emerald ash borer and bronze birch borer (PREPSYS)
Creators: name: Evans, Hugh
Publisher: name: Zenodo
Year: 2016
Subjects: Euphresco, plant health, risk management, Agrilus spp.

description: Slide of the Euphresco project 2015-A-167  'Tree Borers: risk assessment, risk management and preparedness for emerald ash borer and bronze birch borer' (PREPSYS)
description: Project funded through the Euphresco network
Organizing Heterogeneous Samples Using Community Detection of GIMME-Derived Resting State Functional Networks
Creators: name: Nigg, Joel T.
name: Molenaar, Peter C. M.
name: Iyer, Swathi P.
name: Gates, Kathleen M.
name: Fair, Damien A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Clinical investigations of many neuropsychiatric disorders rely on the assumption that diagnostic categories and typical control samples each have within-group homogeneity. However, research using human neuroimaging has revealed that much heterogeneity exists across individuals in both clinical and control samples. This reality necessitates that researchers identify and organize the potentially varied patterns of brain physiology. We introduce an analytical approach for arriving at subgroups of individuals based entirely on their brain physiology. The method begins with Group Iterative Multiple Model Estimation (GIMME) to assess individual directed functional connectivity maps. GIMME is one of the only methods to date that can recover both the direction and presence of directed functional connectivity maps in heterogeneous data, making it an ideal place to start since it addresses the problem of heterogeneity. Individuals are then grouped based on similarities in their connectivity patterns using a modularity approach for community detection. Monte Carlo simulations demonstrate that using GIMME in combination with the modularity algorithm works exceptionally well - on average over 97% of simulated individuals are placed in the accurate subgroup with no prior information on functional architecture or group identity. Having demonstrated reliability, we examine resting-state data of fronto-parietal regions drawn from a sample (N = 80) of typically developing and attention-deficit/hyperactivity disorder (ADHD) -diagnosed children. Here, we find 5 subgroups. Two subgroups were predominantly comprised of ADHD, suggesting that more than one biological marker exists that can be used to identify children with ADHD based from their brain physiology. Empirical evidence presented here supports notions that heterogeneity exists in brain physiology within ADHD and control samples. This type of information gained from the approach presented here can assist in better characterizing patients in terms of outcomes, optimal treatment strategies, potential gene-environment interactions, and the use of biological phenomenon to assist with mental health.
title: Automating the testing of athletes for muscle fatigue asymmetry
Creators: name: Grohs, Aleksandra
name: Ślachciak, Jędrzej
name: Walczak, Tomasz
name: Sopa, Martyna
Publisher: name: Publishing House of Poznan University of Technology
Year: 2023

description: 5th Conference on Biomedical Engineering. Book of Abstracts, 15-16
Self-Supervised Representation Learning for Geographical Data - A Systematic Literature Review. Supplementary Material
Creators: name: Corcoran, Padraig
name: Spasić, Irena
Publisher: name: figshare
Year: 2023
Subjects: Deep learning
Semi- and unsupervised learning

description: This document contains supplementary material for the article entitled "Self-Supervised Representation Learning for Geographical Data - A Systematic Literature Review" by Padraig Corcoran and Irena Spasic.
Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers
Creators: name: Carter, C. Sue
name: Davis, John M.
name: Golding, Jean
name: Ring, Susan M.
name: Connelly, Jessica J.
name: Pembrey, Marcus
name: Davey Smith, George
name: Gregory, Steven P.
name: Harris, James C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundIt is assumed that the oxytocin receptor gene (OXTR) is associated with factors that are related to features of reproduction as well as the currently emerging fields of mood and emotional response.MethodsWe analysed data from over 8000 mothers who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). We determined reproductive, emotional and personality differences related to the two SNPs rs53576 and rs2254298 of the oxytocin receptor gene to determine whether there was evidence in this population for: (i) associations with emotional and personality differences, and (ii) behavioural or environmental links with these SNPs using a hypothesis free approach with over 1000 types of exposure.ResultsOur analyses of 7723 women showed that there were no differences in 11 mood, social or relationship characteristics associated with the rs2254298, and just one with rs53576 (with emotional loneliness) – one statistically significant out of 22 tests is no more than would be expected by chance. There were no interactions with childhood abuse. Using a hypothesis-free approach we found few indicators of environmental or behavioural differences associated with rs2254298, but there was an excess of associations with eating habits with rs53576. The findings included an association with dieting to lose weight, and habits typical of bulimia for the women with GG. The nutrition of the women also showed negative associations of the GG genotype with 13 nutrients, including vitamins D, B12 and retinol, and intake of calcium, potassium and iodine.ConclusionsWe conclude that this large database of pregnant women was unable to provide confirmation of the types of personality associated with these two OXTR SNPs, but we have shown some evidence of eating differences in those with GG on rs53576. Confirmation of our hypothesis free associations using other data sets is important.
USE OF PROVERBS IN THE DEVELOPMENT OF STUDENTS' LEXICAL COMPETENCE (IN THE EXAMPLE OF ENGLISH AND UZBEK LANGUAGES)
Creators: name: Radjapova, Gulrukh
Publisher: name: Zenodo
Year: 2023

description: This topic explores the pedagogical potential of proverbs as a tool for enhancing students' vocabulary skills in the context of learning English and Uzbek. Proverbs, as short, culturally rich expressions, provide a unique resource for language learners to acquire not only words and phrases but also cultural insights and a deeper understanding of the languages they are studying. This study investigates the efficacy of incorporating proverbs into language teaching and learning, considering their impact on students' lexical competence, cultural awareness, and language proficiency in both English and Uzbek. By examining the use of proverbs in these two distinct languages, the research sheds light on the universal and language-specific aspects of proverbs, their role in language acquisition, and their potential to foster cross-cultural understanding. The findings offer valuable insights for educators, curriculum developers, and language learners aiming to improve lexical competence and intercultural communication skills.
Teachers’ training in Marche Region (IT): ICT and continuing professional development
Creators: name: Ceccacci, Laura
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2018

description: Indire’s empirical research regarding digital skills of Italian teachers involved in the National Operational Programme 2007-2013 “Skills for Development” (European Social Fund, ESF), published in 2016, highlighted the existence of a positive link between the number of courses on the use of technologies in teaching and teachers’ training needs. This article presents the results of a quantitative survey that the Regional School Office of Marche carried out at the end of the first year of the implementation of the National Plan for Teachers’ Training 2016-2019. It confirms the high attractiveness of the training paths on digital skills despite the wide range of courses available at regional level. It seems they can endorse positive link between demand and supply in the perspective of lifelong learning. I percorsi di valorizzazione professionale dei docenti nelle Marche: le TIC e la formazione continua La ricerca pubblicata nel 2016 da Indire sulle competenze digitali del personale docente coinvolto nel Programma Operativo Nazionale (PON) 2007-2013 “Competenze per lo sviluppo” (Fondo Sociale Europeo, FSE) aveva messo in luce l’esistenza di una correlazione positiva fra la numerosità dei corsi sull’uso delle tecnologie nella didattica e l’espressione dei fabbisogni formativi in questo ambito. L’intervento presenta i risultati di un monitoraggio di tipo quantitativo condotto dall’Ufficio Scolastico Regionale (USR) Marche sul territorio regionale alla conclusione del primo anno di realizzazione del Piano nazionale per la formazione dei docenti 2016-2019, che confermano il mantenimento di un alto grado di attrattività dei percorsi dedicati al digitale a fronte di un’ampia offerta proposta a livello territoriale. Essi sembrano quindi avere la capacità di attivare circuiti virtuosi, in cui l’offerta alimenta la domanda nell’ottica del lifelong learning e dell’apprendimento permanente.
description: Form@re - Open Journal per la formazione in rete, Vol. 18 No. 2 (2018): Working in the school as a complex organization
Professional development to support teaching innovation. The experiences of the schools leading the Avanguardie Educative Movement
Creators: name: Giunti, Chiara
name: Naldini, Massimiliano
name: Orlandini, Lorenza
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2018

description: This paper describes the elements that characterize innovation processes implemented by the founder member schools (leading schools) which has promoted activities of the Avanguardie Educative Movement together with the National Institute of Documentation, Innovation and Educational Research (Indire Agency). Innovation experiences have been analyzed by using a narrative tool based on the DigCompOrg Framework. This initial analysis led to identify some common elements among the 13 upper secondary schools examined. The professional development resulted to be one of the main drivers for educational and organizational innovation. Lo sviluppo professionale a supporto dell’innovazione didattica. Le esperienze delle scuole capofila del Movimento delle Avanguardie Educative Il presente contributo descrive gli elementi caratterizzanti i processi di innovazione messi in atto dal primo nucleo di scuole (scuole fondatrici) che, insieme a Istituto Nazionale di Documentazione, Innovazione e Ricerca Educativa (Indire), ha promosso le attività del Movimento delle Avanguardie Educative. Le esperienze di innovazione sono state analizzate attraverso una scheda narrativa sviluppata a partire dal Framework DigCompOrg. Da questa prima analisi sono stati individuati alcuni tratti comuni alle 13 scuole secondarie di secondo grado oggetto di studio, tra i quali emerge la centralità dello sviluppo professionale come leva per l’innovazione didattica e organizzativa.
description: Form@re - Open Journal per la formazione in rete, Vol. 18 No. 2 (2018): Working in the school as a complex organization
Education and democracy: the experience of a participatory action research with upper secondary education teachers in a Piemonte area
Creators: name: Boeris, Cristina
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2018

description: This paper aims to present some of the intermediate results of a PhD research on “Teaching Citizenship and the Italian Constitution in a Community of Democratic Practice” which is taking place at the University of Tourin (Department of Educational Sciences). The research has been structured as a research-training, that is a way for the in-service teachers’ training, according to the Decree n. 797/2016. It has been carried out with three groups of upper secondary education teachers in a Piemonte area. It has produced a useful scheme for programming for citizenship skills, a reflection on the importance of the relational climate among teachers and on the features of the school environment that are required to be a Community of democratic Practice. Educazione e democrazia: l’esperienza di una ricerca-formazione con docenti di scuola secondaria di secondo grado in Piemonte Il contributo intende presentare alcuni risultati della ricerca di dottorato dal titolo “L’insegnamento di Cittadinanza e Costituzione in una comunità di pratica democratica”, al momento in corso presso il Dipartimento di Scienze dell’Educazione dell’Università degli Studi di Torino. La ricerca si è strutturata come una ricerca-formazione, costituendo una modalità per la formazione continua dei docenti in servizio secondo le indicazioni del D. M. 797/2016. Essa si è svolta con tre gruppi di docenti delle scuole secondarie di secondo grado del Piemonte e ha prodotto uno schema utile per la programmazione per competenze di cittadinanza, una riflessione sull’importanza del clima relazionale tra i docenti e su quali caratteristiche deve avere l’ambiente scolastico per essere Comunità di Pratica democratica.
description: Form@re - Open Journal per la formazione in rete, Vol. 18 No. 2 (2018): Working in the school as a complex organization