cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation
Creators: name: Sin, Mei-Chan
name: Lin, Wen-Lin
name: Chang-Hung Chen, Jeff
name: Higuchi, Akon
name: Zheng, Jie
name: Chinnathambi, Arunachalam
name: Alharbi, Sulaiman Ali
name: Chang, Yung
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.
Hemocompatible Interface Control via Thermal-Activated Bio-Inspired Surface PEGylation
Creators: name: Sin, Mei-Chan
name: Higuchi, Akon
name: Zheng, Jie
name: Chang, Yung
name: Lin, Wen-Lin
name: Chen, Jeff
name: Chinnathambi, Arunachalam
name: Alharbi, Sulaiman Ali
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Meta Science
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Biotechnology
subject: Physiology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently co-deposited onto versatile substrates of both organic and inorganic materials. Thermal-activated co-deposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine since the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.
Positional selectivity in the interaction of toluene with nitronium ion
Creators: name: Galabov, Boris
name: Koleva, Gergana
name: Schaefer, Henry F.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Three alternative theoretical approaches – electrostatic potentials at the ring carbon atoms, Hirshfeld charges, and electrophile affinities – are employed in predicting the positional selectivity for the nitration of toluene with nitronium ion in dichloromethane medium. The theoretical estimates are compared with recent experimental data of Nieves-Quinones and Singleton. The computed electrostatic potential values at the ring carbon nuclei and the respective Hirshfeld charges predict excellently the regioselectivity of the reaction. The electrophile affinity approach, based on estimated energies of formation of the σ-complex intermediates for the ortho, meta, para, and ipso positions in the ring, also provides reasonable theoretical predictions of reactivity. The mechanism of the nitration reaction is also discussed.
Systemic risk components in a network model of contagion
Creators: name: Staum, Jeremy
name: Feng, Mingbin
name: Liu, Ming
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: We show how to perform a systemic risk attribution in a network model of contagion with interlocking balance sheets, using the Shapley and Aumann–Shapley values. Along the way, we establish new results on the sensitivity analysis of the Eisenberg–Noe network model of contagion, featuring a Markov chain interpretation. We illustrate the design process for systemic risk attribution methods by developing several examples.
The Financial Crisis in Discourse: Banks, Financial Markets, and Political Responses
Creators: name: Fuchs, Doris A.
name: Graf, Antonia
Publisher: name: Universitäts- und Landesbibliothek Münster
Year: 2020
Subjects: subject: 300 Social sciences, Anthropology
subject: 320 Political science (Politics and government)

description: The financial crisis led to an enormous economic downturn as well as dramatic increases in unemployment, insolvencies and public debt. Simultaneously, it revealed fundamental weaknesses of the current functioning of financial markets, if not global economic relations as such. Why, then, has the financial crisis not led to a more fundamental questioning of the politico-economic system and broader political change? In this paper, we aim to find an answer to this question by analyzing the construction of the financial crisis in German public discourse. We show that this construction is characterized by drama and perplexity, normative incoherence, and a lack of access for political alternatives. These findings, in turn, provide an important basis for understanding the political handling of the financial crisis in Germany.
Systemic Risk Components in a Network Model of Contagion
Creators: name: Liu, Ming
name: Staum, Jeremy
name: Feng, Mingbin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Biotechnology

description: We show how to do systemic risk attribution in a network model of contagion with interlocking balance sheets, using the Shapley and Aumann-Shapley values. Along the way, we establish new results on sensitivity analysis of the Eisenberg-Noe network model of contagion, featuring a Markov-chain interpretation. We illustrate the design process for systemic risk attribution methods by developing several of them.
Common filaggrin gene mutations and risk of cervical cancer
Creators: name: Bager, Peter
name: Wohlfahrt, Jan
name: Sørensen, Erik
name: Ullum, Henrik
name: Lotte Nystrup Husemoen, Lise
name: Linneberg, Allan
name: Melbye, Mads
name: P. Thyssen, Jacob
name: Kim Høgdall, Claus
name: Palle, Connie
name: K. Kjær, Susanne
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: Background. As carriers of filaggrin gene (FLG) mutations may have a compromised cervical mucosal barrier against human papillomavirus infection, our primary objective was to study their risk of cervical cancer.Methods. We genotyped 586 cervical cancer patients for the two most common FLG mutations, R501X and 2282del4, using blood from the Copenhagen Hospital Biobank, Denmark. Controls (n = 8050) were genotyped in previous population-based studies. Information on cervical cancer, mortality and emigration were obtained from national registers. Odds ratios (OR) were estimated by logistic regression with adjustment for age at blood sampling, and weighted by the genotype-specific inverse probability of death between diagnosis and sampling. Hazard ratios (HR) were estimated by Cox regression with time since diagnosis as underlying time, and with adjustment for age at diagnosis and stratification by cancer stage.Results. The primary results showed that FLG mutations were not associated with the risk of cervical cancer (6.3% of cases and 7.7% of controls were carriers; OR adjusted 0.81, 95% CI 0.57–1.14; OR adjusted+ weighted 0.96, 95% CI 0.58–1.57). Among cases, FLG mutations increased mortality due to cervical cancer (HR 4.55, 95% CI 1.70–12.2), however, the association was reduced after stratification by cancer stage (HR 2.53, 95% CI 0.84–7.59).Conclusion. Carriage of FLG mutations was not associated with the risk of cervical cancer.
Wiley Open Science Researcher Survey 2016 Infographic
Creators: name: Research, Wiley Market
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: By collating results of our Wiley authors from surveys on Open Science topics in 2013, 2014, and 2016, we have startedto build a valuable dataset for analysis and trend identification. Despite geographical and subject-level differences amongauthors, there are underlying commonalities in Open Science practices. The insights reported by our respondents showa willingness to move forward with open initiatives, but confusion around the best ways to do so.
An Efficient Computational Method for Handling Singular Second-Order, Three Points Volterra Integrodifferential Equations
Creators: name: Arqub, Omar Abu
Publisher: name: figshare
Year: 2019
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: In this paper, a powerful computational algorithm is developed for the solution of classes of singular second-order, three-point Volterra integrodifferential equations in favorable reproducing kernel
Hilbert spaces. The solutions is represented in the form of series in the Hilbert space W23 0 1
with easily computable components. In finding the computational solutions, we use generating the
orthogonal basis from the obtained kernel functions such that the orthonormal basis is constructing in order to formulate and utilize the solutions. Numerical experiments are carried where two
smooth reproducing kernel functions are used throughout the evolution of the algorithm to obtain
the required nodal values of the unknown variables. Error estimates are proven that it converge to
zero in the sense of the space norm. Several computational simulation experiments are given to
show the good performance of the proposed procedure. Finally, the utilized results show that the
present algorithm and simulated annealing provide a good scheduling methodology to multipoint
singular boundary value problems restricted by Volterra operator
Metabonomic analysis of quercetin against the toxicity of chronic exposure to a mixture of four organophosphate pesticides in rat plasma
Creators: name: Cao, Can
name: Zeng, Yan
name: Shi, Haidan
name: Yang, Shuang
name: Bao, Wei
name: Qi, Lei
name: Liu, Ying
name: Zhao, Xiujun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy

description: 1. A metabonomics approach was performed to investigate the effect of quercetin on the toxicity of chronic exposure to a mixture of four organophosphate pesticides (OPs) at their corresponding no-observed-adverse-effect level (NOAEL). The rats were divided into six groups (n = 10/group): control, two different doses of quercetin, OPs mixture and different doses of quercetin plus OPs mixture-treated groups. 2. Nine metabolites, including two quercetin metabolites and seven endogenous metabolites were identified in plasma. The intensities of metabolites significantly changed in the OP mixture-treated group compared with the control group (p < 0.01), such as lysoPE (16:0/0:0), lysoPC (17:0/0:0), lysoPC (15:0/0:0) and 4-pyridoxic acid, significantly increased; by contrast, the intensities of arachidonic acid and citric acid significantly decreased. Anomalous intensity changes in aforementioned metabolites were alleviated in the OP mixture plus 50 mg/kgċbw/d quercetin-treated group compared with the OP mixture-treated group (p < 0.05). 3. The results indicated that quercetin elicited partial protective effects against the toxicity induced by a mixture of OPs, which include regulation of lipid metabolism, improvement of tricarboxylic acid (TCA) cycle disorders, enhancement of antioxidant defence system to protect the liver.
Bioprocess exploration for thermostable α-amylase production of a deep-sea thermophile Geobacillus sp. in high-temperature bioreactor
Creators: name: Jiang, Tao
name: Huang, Mengmeng
name: He, Hao
name: Lu, Jian
name: Zhou, Xiangshan
name: Cai, Menghao
name: Zhang, Yuanxing
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Geobacillus sp. 4j, a deep-sea high-salt thermophile, was found to produce thermostable α-amylase. In this work, culture medium and conditions were first optimized to enhance the production of thermostable α-amylase by statistical methodologies. The resulting extracellular production was increased by five times and reached 6.40 U/ml. Then, a high-temperature batch culture of the thermophile in a 15 l in-house-designed bioreactor was studied. The results showed that a relatively high dissolved oxygen (600 rpm and 15 l/min) and culture temperature of 60°C facilitated both cell growth and α-amylase production. Thus, an efficient fermentation process was established with initial medium of pH 6.0, culture temperature of 60°C, and dissolved oxygen above 20%. It gave an α-amylase production of 79 U/ml and productivity of 19804 U/l·hr, which were 10.8 and 208 times higher than those in shake flask, respectively. This work is useful for deep-sea high-salt thermophile culture, where efforts are lacking presently.
YWP2017 Poster Abstracts
Creators: name: O.Oyebamiji
name: K.F. Chowdhury
name: Y-W. Chu
name: S. Cyhanko
name: H.K. Lehl
name: L. Lopardo
name: M. Marinari
name: M. Massaros
name: A. Massey
name: M.C. Ospina
name: S. Sanchez-Lopez
name: N. Sims
name: I. Stamataki
name: M. Sweiss
name: S. Tabraiz
name: C. Taylor
name: C. Wei
name: Y-S Oon
name: A. Zouboulis
name: G.E. Clayton
Publisher: name: figshare
Year: 2017
Subjects: subject: 90409 Wastewater Treatment Processes
subject: FOS: Chemical engineering
subject: 90509 Water Resources Engineering
subject: FOS: Civil engineering
subject: 90410 Water Treatment Processes
subject: 90508 Water Quality Engineering
subject: 40608 Surfacewater Hydrology
subject: FOS: Earth and related environmental sciences

description: Abstracts submitted to the 18th IWA-UK Young Water Professionals Conference and awarded for Poster presentation
Bioprocess exploration for thermostable α-amylase production of a deep-sea thermophile Geobacillus sp. in high temperature bioreactor
Creators: name: Jiang, Tao
name: Huang, Mengmeng
name: He, Hao
name: Lu, Jian
name: Zhang, Yuanxing
name: Zhou, Xiangshan
name: Cai, Menghao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences

description: ABSTRACTGeobacillus sp. 4j, a deep-sea high-salt thermophile, was found to produce thermostable α -amylase. In this work, culture medium and conditions were firstly optimized to enhance production of thermostable α -amylase by statistical methodologies. The resulting extracellular production was increased by 5 times and reached 6.40 U/ml. Then, a high-temperature batch culture of the thermophile in a 15 L house designed bioreactor was studied. The results showed that, a relatively high dissolved oxygen (600 rpm and 15 L/min) and culture temperature of 60°C facilitated both cell growth and α -amylase production. Thus, an efficient fermentation process was established with initial medium pH of 6.0, culture temperature of 60°C and keeping dissolved oxygen above 20%. It gave a α -amylase production of 79 U/ml and productivity of 19804 U/(L · h), which were 10.8 and 208 times higher than those in shake flask, respectively. This work is useful for deep-sea high-salt thermophile culture, where efforts are lacking presently.
Polyphenols of virgin coconut oil prevent pro-oxidant mediated cell death
Creators: name: Soorya Parathodi Illam
name: Arunaksharan Narayanankutty
name: Achuthan C. Raghavamenon
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer

description: Virgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP documented the presence of gallic acid, ferulic acid (FA), quercetin, methyl catechin, dihydrokaempferol and myricetin glycoside. Pre-treatment of VCOP at different concentrations (25–100 μg/mL) significantly reduced the H2O2 and 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH) induced cell death in HCT-15 cells. Giving further insight to its mechanistic basis, oxidative stress induced alterations in glutathione (GSH) levels and activities of GR (Glutathione–Reductase), GPx (Glutathione–Peroxidase), GST (Glutathione-S-Transferase) and catalase (CAT) were restored to near-normal by VCOP, concomitantly reducing lipid peroxidation. The efficacy of VCOP was similar to that of Trolox and FA added in culture. The study thus suggests that VCOP protects cells from pro-oxidant insults by modulating cellular antioxidant status.
Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549
Creators: name: Zhang, Tingting
name: Li, Xiaoming
name: Guo, Bingyu
name: Su, Jingyuan
name: Wang, Kaiwen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Engineering
subject: Biochemistry

description: Background: Fangchinoline as a novel anti-tumor agent has been paid attention in several types of cancers cells except lung cancer. Here we have investigated the effect of fangchinoline on A549 cells and its underlying mechanism.Purpose: The purpose of this work was to study the effect of fangchinoline on A549 cells.Methods: Four lung cancer cell lines (A549, NCI-H292, NCI-H446, and NCI-H460) were exposed to varying concentrations (10–40 μmol/l) of fangchinoline to observe the effect of fangchinoline on the four lung cancer cell lines and to observe the changes of the lung cancer cell on proliferation, apoptosis, and invasion.Results: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.Discussion: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways.Conclusion: Fangchinoline could inhibit the phosphorylation of FAKp-Tyr397, at least partially. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.
Influence of quartz exposure on lung cancer types in cases of lymph node–only silicosis and lung silicosis in German uranium miners
Creators: name: Mielke, Stefan
name: Taeger, Dirk
name: Weitmann, Kerstin
name: Brüning, Thomas
name: Hoffmann, Wolfgang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Inhaled crystalline quartz is a carcinogen. Analyses show differences in the distribution of lung cancer types depending on the status of silicosis. Using 2,524 lung tumor cases from the WISMUT autopsy repository database, silicosis was differentiated into cases without silicosis in lung parenchyma and its lymph nodes, with lymph node–only silicosis, or with lung silicosis including lymph node silicosis. The proportions of adenocarcinoma, squamous cell carcinoma, and small-cell lung carcinoma mortality for increasing quartz exposures were estimated in a multinomial logistic regression model. The relative proportions of the lung cancer subtypes in lymph node–only silicosis were more similar to lung silicosis than without any silicosis. The results support the hypothesis that quartz-related carcinogenesis in case of lymph node–only silicosis is more similar to that in lung silicosis than in without silicosis.
An Efficient Computational Method for Handling Singular Second-Order, Three Points Volterra Integrodifferential Equations.pdf
Creators: name: Arqub, Omar Abu
Publisher: name: figshare
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: In this paper, a powerful computational algorithm is developed for the solution of classes of singular second-order, three-point Volterra integrodifferential equations in favorable reproducing kernel
Hilbert spaces. The solutions is represented in the form of series in the Hilbert space W23 0 1
with easily computable components. In finding the computational solutions, we use generating the
orthogonal basis from the obtained kernel functions such that the orthonormal basis is constructing in order to formulate and utilize the solutions. Numerical experiments are carried where two
smooth reproducing kernel functions are used throughout the evolution of the algorithm to obtain
the required nodal values of the unknown variables. Error estimates are proven that it converge to
zero in the sense of the space norm. Several computational simulation experiments are given to
show the good performance of the proposed procedure. Finally, the utilized results show that the
present algorithm and simulated annealing provide a good scheduling methodology to multipoint
singular boundary value problems restricted by Volterra operator
Организационно-экономические факторы и резервы повышения эффективности производства зерна в современных условиях
Creators: name: Чабанный Александр Анатольевич
Publisher: name: European research
Year: 2016
Subjects: КОНЦЕНТРАЦИЯ ПРОИЗВОДСТВА
CONCENTRATION OF PRODUCTION
ИНТЕНСИФИКАЦИЯ ПРОИЗВОДСТВА
PRODUCTION INTENSIFICATION
МИНЕРАЛЬНЫЕ УДОБРЕНИЯ
MINERAL FERTILIZERS
СОРТОСМЕНА
ИННОВАЦИЯ
INNOVATION
SORT CHANGE

description: Дается определение концентрации производства как основного средства производства, приводится такой резерв повышения эффективности зернового производства, как интенсификация производства зерна, дается характеристика применения минеральных удобрений и сортосмены при производстве зерна.
Simple synthesis of 1-substituted-4-vinyl-1,2,3-triazoles based on polystyrene-supported sulfonyl chloride
Creators: name: Wang, Zhe
name: Sheng, Shou-Ri
name: Wei, Mei-Hong
name: Liu, Xiao-Ling
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Polystyrene-supported but-3-ynyl sulfonate reagent has been developed and applied to the traceless solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles by CuI-promoted 1,3-dipolar cycloaddition reaction with various organic azides and subsequent cleavage from the polymer support through elimination reaction mediated by 1.8-diazabicyclo[5,4,0]undec-7-ene (DBU). The advantages of this new synthetic method include simple operation and moderate to good yields of the products, as well as good stability of the reagent.
Simple Synthesis of 1-Substituted-4-vinyl-1,2,3-triazoles Based on Polystyrene-Supported Sulfonyl Chloride
Creators: name: Wang, Zhe
name: Liu, Xiao-Ling
name: Sheng, Shou-Ri
name: Wei, Mei-Hong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Evolutionary Biology
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Polystyrene-supported but-3-ynyl sulfonate reagent has been developed and applied to the traceless solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles by CuI-promoted 1,3-dipolar cycloaddition reaction with various organic azides and subsequent cleavage from the polymer support through elimination reaction mediated by 1.8-diazabicyclo[5,4,0]undec-7-ene (DBU). The advantages of this new synthetic method include simple operation and moderate to high of the products, as well as good stability of the reagent.
Supplementary Material for: Differential Allelic Expression of HTR1B in Suicide Victims: Genetic and Epigenetic Effect of the Cis-Acting Variants
Creators: name: Bani-Fatemi, A.
name: Howe, A.
name: Zai, C.
name: Kennedy, J.L.
name: Vincent, J.
name: Strauss, J.
name: Wong, A.
name: De Luca, V.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Objectives: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. Methods: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42). Finally, we performed a family-based association study of the C861G and promoter variants in 162 nuclear families using suicidal behavior severity scores as phenotype. Results: We observed no alterations in the C/G expression ratio in suicide victims compared to nonsuicide controls (p = 0.370). When comparing the LD between the C861G and cis-acting SNPs, we did not find any differences in SA and NSA. There was no association between preferential transmission of cis-acting SNPs and suicidal behavior severity scores in both maternal and paternal meiosis. Conclusions: We found several promoter variants in LD that may potentially influence the allelic imbalance in the C861G variant. However, no evidence of allelic imbalance nor parent-of-origin effects of the C861G variant was observed in suicidal behavior. Further research is required to assess this marker in larger cohorts.
Supplementary Material for: Differential Effects of Inflammatory and Psychosocial Stress on Mood, Hypothalamic-Pituitary-Adrenal Axis, and Inflammation in Remitted Depression
Creators: name: Niemegeers, P.
name: De Boer, P.
name: Dumont G.J.H.
name: Van Den Eede, F.
name: Fransen, E.
name: Claes, S.J.
name: Morrens, M.
name: Sabbe B.G.C.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: Major depressive disorder (MDD) is highly recurrent. This may be due to increased stress sensitivity after remission. Both inflammatory and psychosocial stressors are implicated in the pathogenesis of MDD, but the additive or differential effect is unclear. Methods: We conducted a single-blind placebo-controlled study to investigate the effects of inflammatory stress (i.e., typhoid vaccination), psychosocial stress (i.e., Trier Social Stress Test [TSST]), or a combination of both in women (25-45 years old) with (partially) remitted recurrent MDD (n = 21) and healthy female controls (n = 18). We evaluated the effect on mood measured by the Profile of Mood States, markers of the hypothalamic-pituitary-adrenal (HPA) axis activity, and inflammatory system activation. The study was performed during 2 testing days, separated by a washout of 7-14 days. In a crossover design, subjects received one of the interventions on one day and placebo on the other. Results: A lowering of mood was seen in patients (β [95% CI] = -4.79 [-6.82 to -2.75], p < 0.001) only after vaccination, but not after the TSST or the combination; this effect was not observed in controls. Controls experienced a significantly different response on adrenocorticotropic hormone (ACTH) after vaccination, with a general rise in ACTH not observed in patients. In both groups, the TSST activated the HPA axis and suppressed the inflammatory parameters. Conclusions: There is a differential effect of inflammatory and psychosocial stress on mood and HPA axis activation in patients with remitted recurrent MDD. This may be an interesting treatment target in MDD.
Distribution and Diversity of Cyanobacteria and Eukaryotic Algae in Qinghai–Tibetan Lakes
Creators: name: Liu, Xiaolei
name: Hou, Weiguo
name: Dong, Hailiang
name: Wang, Shang
name: Jiang, Hongchen
name: Wu, Geng
name: Yang, Jian
name: Li, Gaoyuan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Cyanobacteria and eukaryotic algae are important primary producers in a variety of environments, yet their distribution and response to environmental change in saline lakes are poorly understood. In this study, the community structure of cyanobacteria and eukaryotic algae in the water and surface sediments of six lakes and one river on the Qinghai–Tibetan Plateau were investigated with the 23S rRNA gene pyrosequencing approach. Our results showed that salinity was the major factor controlling the algal community composition in these aquatic water bodies and the community structures of water and surface sediment samples grouped according to salinity. In subsaline–mesosaline lakes (salinity: 0.5–50 g L−1), Cyanobacteria (Cyanobium, Synechococcus) were highly abundant, while in hypersaline lakes (salinity: >50 g L−1) eukaryotic algae including Chlorophyta (Chlorella, Dunaliella), Bacillariophyta (Fistulifera), Streptophyta (Chara), and Dinophyceae (Kryptoperidinium foliaceum) were the major members of the community. The relative abundance ratio of cyanobacteria to eukaryotic algae was significantly correlated with salinity. The algae detected in Qinghai–Tibetan lakes exhibited a broader salinity range than previously known, which may be a result of a gradual adaptation to the slow evolution of these lakes. In addition, the algal community structure was similar between water and surface sediment of the same lake, suggesting that sediment algal community was derived from water column.
Distribution and diversity of Cyanobacteria and eukaryotic algae in Qinghai-Tibetan lakes
Creators: name: Liu, Xiaolei
name: Hou, Weiguo
name: Dong, Hailiang
name: Wang, Shang
name: Jiang, Hongchen
name: Wu, Geng
name: Yang, Jian
name: Li, Gaoyuan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences

description: Cyanobacteria and eukaryotic algae are important primary producers in a variety of environments, yet their distribution and response to environmental change in saline lakes are poorly understood. In this study, the community structure of cyanobacteria and eukaryotic algae in the water and surface sediments of six lakes and one river on the Qinghai-Tibetan Plateau were investigated with the 23S rRNA gene pyrosequencing approach. Our results showed that salinity was the major factor controlling the community composition in these aquatic water bodies and the algal community structures of water and surface sediment samples grouped according to salinity. In subsaline-mesosaline lakes (salinity: 0.5-50 g L−1), Cyanobacteria (Cyanobium, Synechococcus) were highly abundant, while in hypersaline lakes (salinity: >50 g L−1) eukaryotic algae including Chlorophyta (Chlorella, Dunaliella), Bacillariophyta (Fistulifera), Streptophyta (Chara), and Dinophyceae (Kryptoperidinium foliaceum) were the major members of the community. The relative abundance ratio of cyanobacteria to eukaryotic algae was significantly correlated with salinity. The algae detected in Qinghai-Tibetan lakes exhibited a broader salinity range than previously known, which may be a result of a gradual adaptation to the slow evolution of these lakes. In addition, the algal community structure was similar between water and surface sediment of the same lake, suggesting that sediment algal community was derived from water column.
Supplementary Material for: Barber-Say Syndrome and Ablepharon-Macrostomia Syndrome: A Patient's View
Creators: name: De Maria, B.
name: De Jager, T.
name: Sarubbi, C.
name: Bartsch, O.
name: Bianchi, A.
name: Brancati, F.
name: H.-Y.B., Chung
name: David, A.
name: Kariminejad, A.
name: Foresti, M.
name: Gallottini, M.
name: Isidor, B.
name: Marchegiani, S.
name: Martins, F.
name: Mazzanti, L.
name: Roche, N.
name: Singh, A.
name: Stevens, C.
name: Suga, K.
name: Zenker, M.
name: Hennekam, R.C.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Barber-Say syndrome (BSS) and ablepharon-macrostomia syndrome (AMS) are infrequently reported congenital malformation disorders caused by mutations in the TWIST2 gene. Both are characterized by abnormalities in ectoderm-derived structures and cause a very unusual morphology of mainly the face in individuals with otherwise normal cognition and normal physical functioning. We studied the impact that the presence of BSS and AMS has on psychosocial functioning of affected individuals and their families, using their point of view to start with. We tabulated frequently asked questions from affected individuals and families, and a parent of an affected child and an affected adult woman offered personal testimonies. We focused on perception of illness, body satisfaction, and the consequences for an otherwise normal individual who has a disorder that interferes with body image. The importance of paying particular attention to the management of both the physical appearance and the consequences of these entities on the quality of life is stressed by the affected individuals themselves.
AFRICAN PERSPECTIVE ON SUSTAINABLE DEVELOPMENT The Potentials of Pan-African Research Communities to Cooperate for Sustainable Development - Ethiopian Point of View
Creators: name: Margareth Gfrerer, Solomon Mogus & Zelalem Assefa
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020

description: AFRICAN PERSPECTIVE ON SUSTAINABLE DEVELOPMENT The Potentials of Pan-African Research Communities to Cooperate for Sustainable Development - Ethiopian Point of View
Influence of quartz exposure on lung cancer types in cases of lymph node-only silicosis and lung silicosis in German uranium miners
Creators: name: Mielke, Stefan
name: Taeger, Dirk
name: Weitmann, Kerstin
name: Brüning, Thomas
name: Hoffmann, Wolfgang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Inhaled crystalline quartz is carcinogen. Analyses show differences in the distribution of lung cancer types depending on the status of silicosis. 2,524 lung tumor cases from the WISMUT autopsy repository database were used. Silicosis was differentiated in cases without silicosis in lung parenchyma and its lymph nodes, with lymph node-only silicosis or with lung silicosis including lymph node silicosis. The proportions of adenocarcinoma, squamous cell and small cell lung carcinoma mortality for increasing quartz exposures were estimated in a multinomial logistic regression model. The relative proportions of the lung cancer subtypes in lymph node-only silicosis were more similar to lung silicosis than without any silicosis. The results support the hypothesis that quartz-related carcinogenesis in case of lymph node-only silicosis is more similar to that in lung silicosis than in without silicosis.
Separation of urea, hexamethylenetetramine, and their reaction products in sol–gel feed solution by zwitterionic HILIC
Creators: name: Perumpillil George, Jaison
name: Kumar, Pranaw
name: Madhukar Telmore, Vijay
name: Chandra Deb, Ashok
name: Kumar, Ashok
name: Radhakrishna, Jayanthi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Studies were carried out to develop a chromatographic methodology based on hydrophilic interaction liquid chromatography (HILIC) for the separation of various reaction products of hexamethylenetetramine (HMTA) –urea used in the sol–gel process for the preparation of ceramic microspheres. Different chromatographic parameters such as organic modifiers, pH of mobile phase, buffer concentration, column temperature, etc. were studied to arrive at the optimum conditions for separation. Compounds such as urea, monomethylolurea (MMU), dimethylolurea (DMU), and HMTA were separated from a synthetic mixture using a mobile phase consisting of acetonitrile and acetate buffer of pH 6. The methodology developed based on HILIC stationary phase is simple and amicable for integration with electrospray ionization mass spectrometry (ESI-MS) to identify the unknown reaction products. The methodology was applied for the separation of reaction products in pre-boiled and untreated urea–HMTA mixtures used as feed in the sol–gel process.
The Axon Disinhibition Mechanism (ADM):  A Hypothesis for the Neural Basis of Mind
Creators: name: Thomas, Abraham
name: Thomas, Abraham
Publisher: name: Zenodo
Year: 2024

description: The Axon Disinhibition Mechanism (ADM) proposes a novel explanation for the complexities of human cognition. It leverages the basic binary firing of neurons to explain the subtlety of memory, intuition, emotions, intelligence, and consciousness. ADM posits a disinhibition process at the synaptic level that dynamically selects relevant information from the vast repository of neuronal patterns. This hypothesis explores the potential of ADM in shaping human mental activity and its implications for understanding the mind-brain relationship.
title: Материалы научной конференции с международным участием "Неделя науки СПбПУ", 18–23 ноября 2019 года. Институт физической культуры, спорта и туризма
Creators: name: Научная конференция с международным участием "Неделя науки СПбПУ" (2019; Санкт-Петербург)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019

description: В сборник включены статьи студентов, аспирантов, молодых ученых и сотрудников СПбПУ, университетов, научных организаций и предприятий Санкт-Петербурга, России, зарубежных стран по материалам докладов, принятых на секционные заседания конференции «Неделя науки СПбПУ» Института физической культуры, спорта и туризма. Статьи отражают современный уровень научно-исследовательской работы участников конференции в области физической культуры, физической подготовки, спорта и туризма. Представляют интерес для специалистов в различных областях знаний, учащихся и работников системы высшего образования и Российской академии наук.
Prediction of therapy response in ovarian cancer: Where are we now?
Creators: name: Bairi, Khalid El
name: Amrani, Mariam
name: Kandhro, Abdul Hafeez
name: Afqir, Said
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Therapy resistance is a major challenge in the management of ovarian cancer (OC). Advances in detection and new technology validation have led to the emergence of biomarkers that can predict responses to available therapies. It is important to identify predictive biomarkers to select resistant and sensitive patients in order to reduce important toxicities, to reduce costs and to increase survival. The discovery of predictive and prognostic biomarkers for monitoring therapy is a developing field and provides promising perspectives in the era of personalized medicine. This review article will discuss the biology of OC with a focus on targetable pathways; current therapies; mechanisms of resistance; predictive biomarkers for chemotherapy, antiangiogenic and DNA-targeted therapies, and optimal cytoreductive surgery; and the emergence of liquid biopsy using recent studies from the Medline database and ClinicalTrials.gov.
Separation of Urea, Hexamethylenetetramine and Their Reaction Products in Sol-Gel Feed Solution by Zwitterionic HILIC
Creators: name: Kumar, Ashok
name: Perumpillil George, Jaison
name: Kumar, Pranaw
name: Madhukar Telmore, Vijay
name: Chandra Deb, Ashok
name: Radhakrishna, Jayanthi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Genetics
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: ABSTRACTStudies were carried out to develop a chromatographic methodology based on hydrophilic interaction liquid chromatography (HILIC) for the separation of various reaction products of hexamethylenetetramine (HMTA) - urea used in the sol-gel process for the preparation of ceramic microspheres. Different chromatographic parameters such as organic modifiers, pH of mobile phase, buffer concentration, column temperature etc. were studied to arrive at the optimum conditions for separation. The compounds such as urea, monomethylolurea, dimethylolurea and HMTA were separated from a synthetic mixture using a mobile phase consisting of acetonitrile and acetate buffer of pH 6. The methodology developed based on HILIC stationary phase is simple and amicable for integration with ESI-MS to identify the unknown reaction products. The methodology was applied for the separation of reaction products in a pre-boiled and an untreated urea-HMTA mixtures used as feed in sol-gel process.
Supplementary Material for: Use of Phosphorus Binders among Non-Dialysis Chronic Kidney Disease Patients and Mortality Outcomes
Creators: name: Bhandari, S.K.
name: I.-L.A., Liu
name: Kujubu, D.A.
name: Huynh, T.
name: Behayaa, H.
name: Kovesdy, C.P.
name: Kalantar-Zadeh, K.
name: Jacobsen, S.J.
name: Sim, J.J.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Whether the benefits of phosphorus binders extend to those without end stage renal disease is uncertain. Among a large diverse non-dialysis chronic kidney disease (CKD) population with hyperphosphatemia, we sought to evaluate phosphorus binder use and compare mortality risk between patients prescribed and not prescribed binders. Methods: A retrospective cohort study within an integrated health system (January 1, 1998 - December 31, 2012) among CKD patients (age ≥18) was performed. Non-dialysis CKD patients with 2 separate estimated glomerular filtrate rate (eGFR) <30 mL/min/1.73 m2 and serum phosphorus ≥5.0 mg/dL within 180 days of eGFR were included. Multivariable cox proportional hazards and inverse probability of treatment-weighted models were used to estimate mortality hazard ratios (HRs) for patients who received phosphorus binders compared to no binders. Results: Among 10,165 study patients, 2,733 subjects (27%) received phosphorus binders. Compared to the no-phosphorus-binder group, the binder group had mortality HRs (95% CI) of 0.86 (0.79-0.94) and 0.86 (0.80-0.93) using traditional multivariable and inverse probability of treatment-weighted models respectively. Sensitivity analyses removing patients who were prescribed binders >180 days after index date revealed no difference in mortality between those with binders and with no binders. Conclusion: Our findings from a real-world clinical environment revealed that 27% of hyperphosphatemic non-dialysis CKD patients were prescribed binders. They also had lower risk of mortality compared to those not prescribed phosphorus binders. However, the lower mortality risk was not observed when we accounted for immortal time bias. Whether phosphorus binder use in CKD improves survival remains to be determined.