cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Giochi diplomatici. Sport e politica estera nell'Italia del secondo dopoguerra (1943-1953)
Diplomatic Games. Sport and Foreign Policy in post-war Italy (1943-1953)
Creators: name: Sbetti, Nicola <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: M-STO/04 Storia contemporanea

description: Questa tesi di dottorato, partendo dall’assunto teorico secondo cui lo sport, pur essendo un fenomeno periferico e non decisivo del sistema politico internazionale, debba considerarsi, in virtù della sua elevata visibilità, sia come un componente delle relazioni internazionali sia come uno strumento di politica estera, si pone l’obiettivo di investigare, con un approccio di tipo storico-politico, l’attività internazionale dello sport italiano nel decennio che va dal 1943 al 1953. Nello specifico viene dedicata una particolare attenzione agli attori e alle istituzioni della “politica estera sportiva”, al rientro dello sport italiano nel consesso internazionale e alla sua forza legittimante di attrazione culturale. Vengono approfonditi altresì alcuni casi relativi a «crisi politiche» che influirono sullo sport e a «crisi sportive» che influenzarono la politica. La ricerca viene portata avanti con lo scopo primario di far emergere, da un lato se e quanto coscientemente lo sport sia stato usato come strumento di politica estera da parte dei governi e della diplomazia dell’Italia repubblicana, dall’altro quanto e con quale intensità lo sviluppo dell’attività internazionale dello sport italiano abbia avuto significative ripercussioni sull’andamento e dai rapporti di forza della politica internazionale.
description: The argument of the present work is that sport is a peripheral and not vital phenomenon in the international political system, but because of its high public visibility it has to be considered both as a part of international relations and a foreign policy tool for governments and diplomacy. The present PhD study aims at inquiring, in a historical-political approach, into the international role of sport in the decade 1943-1953. It will give particular attention to the actors and institutions of the “sporting foreign policy”, to the Italian re-entering into the international sport arena and its soft power; in addition, attention will be drawn to some particular “political crises” that touched the sporting activity and to some “sporting crises” obliging the intervention of the government and diplomacy. The final aim of the study is to understand if and how sport was consciously used as a foreign policy tool, and at what degree of intensity the international activity of the Italian sport was influenced by the development and the balance of power in international politics.
Optimizing Disease Prediction with Artificial Intelligence Driven Feature Selection and Attention Networks
Creators: name: Dhinakaran, D.
name: Raja, S. Edwin
name: Thiyagarajan, M.
name: Jasmine, J. Jeno
name: Raghavan, P.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The rapid integration of machine learning methodologies in healthcare has ignited innovative strategies for disease prediction, particularly with the vast repositories of Electronic Health Records (EHR) data. This article delves into the realm of multi-disease prediction, presenting a comprehensive study that introduces a pioneering ensemble feature selection model. This model, designed to optimize learning systems, combines statistical, deep, and optimally selected features through the innovative Stabilized Energy Valley Optimization with Enhanced Bounds (SEV-EB) algorithm. The objective is to achieve unparalleled accuracy and stability in predicting various disorders. This work proposes an advanced ensemble model that synergistically integrates statistical, deep, and optimally selected features. This combination aims to enhance the predictive power of the model by capturing diverse aspects of the health data. At the heart of the proposed model lies the SEV-EB algorithm, a novel approach to optimal feature selection. The algorithm introduces enhanced bounds and stabilization techniques, contributing to the robustness and accuracy of the overall prediction model. To further elevate the predictive capabilities, an HSC-AttentionNet is introduced. This network architecture combines deep temporal convolution capabilities with LSTM, allowing the model to capture both short-term patterns and long-term dependencies in health data. Rigorous evaluations showcase the remarkable performance of the proposed model. Achieving a 95% accuracy and 94% F1-score in predicting various disorders, the model surpasses traditional methods, signifying a significant advancement in disease prediction accuracy. The implications of this research extend beyond the confines of academia.
description: 16 Pages, 4 Figures
A systematic review on the economic burden of interstitial lung disease and the cost-effectiveness of current therapies
Creators: name: Chen, Wenjia
name: Wong, Alyson
name: Koo, John
name: Ryerson, Christopher J.
name: Sadatsafavi, Mohsen
name: Chen, Wenjia
Publisher: name: BioMed Central
Year: 2022

description: Background The economic burden of interstitial lung disease (ILD) is unknown, limiting informed resource allocation and planning. We sought to conduct the first systematic review on the direct, indirect, and overall costs associated with ILD and to evaluate the cost-effectiveness of current therapies globally. Methods We conducted systematic reviews of ILD disease cost studies and cost-effectiveness analyses (CEAs) using MEDLINE, Embase, and Web of Science databases between 2000 and 2020. We compared ILD costs between countries according to the share of costs towards each country’s respective gross domestic product (GDP) per capita. Costs are reported in 2020 USD. Results We identified 25 disease cost studies and 7 CEAs. The direct medical costs ranged between $1824 and $116,927 annually per patient (median $32,834; 14–180% of GDP per capita in Western countries). The leading drivers of direct costs were inpatient (55%), outpatient (22%), and medication costs (18%), based on pooled estimates. Annual indirect costs ranged from $7149 to $10,902 per employed patient (median $9607; 12–23% of GDP per capita). Among the 7 CEAs, only 1 study (14%) showed an ILD therapy (ambulatory oxygen) was cost-effective compared to best supportive care. Conclusion The direct and indirect costs associated with ILD are consistently high in all countries with available data, with cost-effectiveness profiles of new therapies generally undesirable. Globally, the median total direct cost for ILD equates to 51% of a country’s GDP per capita and has been increasing over time.
Epistemic communities in knowledge organization: an analysis of research trends in the Knowledge Organization journal
Creators: name: Guimaraes, Jose Augusto
Publisher: name: ISKO UK
Year: 2015
Subjects: Knowledge Organization
Citation analysis
Domain analysis
Epistemic communities

description: Considering knowledge organization as a domain in a continuous process of theoretical-methodological consolidation, it becomes important to identify its epistemological configuration and “epistemic communities” in order to measure its impact on society and scholarship. As a reflection of the ISKO and knowledge organization activities, the Knowledge Organization (KO) journal was analysed for the period 1994-2014 in order to identify and characterise the core of researchers that the knowledge organization community consider as central and more impactful. In addition, we analysed the impact of this literature on the LIS scientific domain as a whole, by means of the presence of such literature also in scholarly journals other than KO. The results reveal that the consolidation process of the KO domain and the epistemic communities’ progress occur in a dynamic and well-balanced way with a strong and widespread impact on the LIS scientific context as a whole. The dynamic and evolving nature of these groups, with citations growing in number and new authors slowly emerging for each period, makes it possible to conclude that the ISKO epistemic communities and their impact are not only changing but also expanding.
Additional file 1 of Isolation, marginalisation and disempowerment – understanding how interactions with health providers can influence smoking cessation in pregnancy
Creators: name: Fletcher, Cherise
name: Hoon, Elizabeth
name: Gialamas, Angela
name: Dekker, Gustaaf
name: Lynch, John
name: Smithers, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1.
The Effect of Alcohol Intoxication on Driving Performance: An Exploration of Epidemiology, Impairment and Risk Factors Contributing to Drink-Driving Behaviour
Creators: name: Garrisson, Harriet
Publisher: name: Swinburne
Year: 2024

description: Will a drink or two actually make you a better driver? This thesis addressed this enduring debate by diving into decades of drink-driving research. By integrating epidemiological data and experimental investigations, this work adds to the current understanding of how alcohol impairs driving and related neurocognitive functions. A key focus was to determine the prevalence of such behaviour and quantify the consequent impairment. Despite an inability to identify their impairment, drivers under the influence consistently exhibit poorer performance on driving tasks. In shedding light on this contradiction, the findings of this thesis question the unfounded self-assurance of those who consider themselves “good drunk drivers” and contributes to a critical conversation about road safety.
Additional file 1 of Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs
Creators: name: Halecker, Sabrina
name: Krabben, Ludwig
name: Kristiansen, Yannick
name: Krüger, Luise
name: Möller, Lars
name: Becher, Dietmar
name: Laue, Michael
name: Kaufer, Benedikt
name: Reimer, Christian
name: Denner, Joachim
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].
Biocide susceptibility and antimicrobial resistance of Escherichia coli isolated from swine feces, pork meat and humans in Germany
Creators: name: Silva, David Attuy Vey Da
name: Dieckmann, Ralf
name: Makarewicz, Oliwia
name: Al Dahouk, Sascha
Publisher: name: My University
Year: 2023
Subjects: Kolibakterien

description: Phenotypic susceptibility testing of Escherichia (E.) coli is an essential tool to gain a better understanding of the potential impact of biocide selection pressure on antimicrobial resistance. We, therefore, determined the biocide and antimicrobial susceptibility of 216 extended-spectrum Î2-lactamase-producing (ESBL) and 177 non-ESBL E. coli isolated from swine feces, pork meat, voluntary donors and inpatients and evaluated associations between their susceptibilities. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of benzalkonium chloride, chlorhexidine digluconate (CHG), chlorocresol (PCMC), glutaraldehyde (GDA), isopropanol (IPA), octenidine dihydrochloride and sodium hypochlorite (NaOCl) showed unimodal distributions, indicating the absence of bacterial adaptation to biocides due to the acquisition of resistance mechanisms. Although MIC95 and MBC95 did not vary more than one doubling dilution step between isolates of porcine and human origin, significant differences in MIC and/or MBC distributions were identified for GDA, CHG, IPA, PCMC and NaOCl. Comparing non-ESBL and ESBL E. coli, significantly different MIC and/or MBC distributions were found for PCMC, CHG and GDA. Antimicrobial susceptibility testing revealed the highest frequency of resistant E. coli in the subpopulation isolated from inpatients. We observed significant but weakly positive correlations between biocide MICs and/or MBCs and antimicrobial MICs. In summary, our data indicate a rather moderate effect of biocide use on the susceptibility of E. coli to biocides and antimicrobials. © 2023 by the authors
No Evidence of Benefits of Host Nano-Carbon Materials for Practical Lithium Anode-Free Cells
Creators: name: Zhou, Bingxin
name: Fang, Baizeng
name: Stoševski, Ivan
name: Bonakdarpour, Arman
name: Wilkinson, David P.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Nano-carbon-based materials are widely reported as lithium host materials in lithium metal batteries (LMBs); however, researchers report contradictory claims as to where the lithium plating occurs. Herein, the use of pure hollow core-carbon spheres coated on Cu (PHCCSs@Cu) to study the lithium deposition behavior with respect to this type of structure in lithium anode-free cells is described. It is demonstrated that the lithium showed some initial and limited intercalation into the PHCCSs and then plated on the external carbon walls and the top surface of the carbon coating during the charging process. The unfavorable deposition of lithium inside the PHCCSs is discussed from the viewpoint of lithium-ion transport and lithium nucleation. The application potential of PHCCSs and the data from these LMB studies are also discussed.
A review of clinical applications of pharmacokinetic simulations for a 2-month long-acting injectable formulation of aripiprazole
Creators: name: Fagiolini, Andrea
name: Wang, Yanlin
name: Bioque, Miquel
name: Harlin, Matthew
name: Larsen, Frank
name: Wang, Xiaofeng
name: Park, Wansu
name: Rich, Benjamin
name: Gobburu, Jogarao V.
name: Raoufinia, Arash
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Aripiprazole 2-month ready-to-use (Ari 2MRTU) is a long-acting injectable antipsychotic that was approved for use in Europe in March 2024, for the maintenance treatment of schizophrenia in adult patients stabilized with aripiprazole; it is administered via gluteal intramuscular injection once every two months. This review examines population pharmacokinetic model-based simulations relevant to the use of Ari 2MRTU in Europe, accompanied by expert commentary that contextualizes the simulations and highlights the potential implications of the availability of Ari 2MRTU for patients, caregivers, and clinicians. Various simulations conducted across 8 weeks (representing the first dosing interval), or 32 weeks (representing maintenance dosing) demonstrated an aripiprazole exposure profile for Ari 2MRTU that was similar to aripiprazole once-monthly (AOM), but with an extended dosing interval. In treatment initiation scenarios consistent with the European label, therapeutic levels of aripiprazole (i.e. ≥95 ng/mL) were maintained when transitioning from either AOM or oral aripiprazole, including with a two-injection start regimen with no requirement for 14 days of oral aripiprazole supplementation. Therapeutic levels of aripiprazole were also observed for treatment maintenance scenarios, except when dosing of Ari 2MRTU was delayed by 8 weeks. The availability of Ari 2MRTU extends the range of options for the maintenance treatment of schizophrenia in Europe. Ari 2MRTU may provide adherence benefits due to its extended dosing interval and the option to initiate treatment using a two-injection start regimen, which does not require 14 days of overlapping oral supplementation.
Il personale docente: stato giuridico, reclutamento, evoluzione
Creators: name: Rossi, Paolo
Publisher: name: Università degli Studi di Milano
Year: 2016
Subjects: University professors ; legal status ; recruitment; aging; gender effects; geographic distribution; statistical data

description: The changes in the legal status and in the recruiting procedures of Italian University professors and researchers occurred in the last forty years are summarily described.

The related recruiting policies are analyzed in detail, reporting yearly data on recruitment and on the (growing) average age of access to the different roles.

Data on the quantitative evolution of the academic staff and on its constant aging are presented (and discussed) on a yearly basis from the early Eighties to the year 2015. The distinct evolution of different scientific areas is analyzed. Gender effects (and in particular the “glass ceiling”) are considered.

The most significant changes in the geographic distribution of Universities and of their teaching body (from the year 1939 to the present day) are described.
Some general conclusions on the Italian University system and its recent evolution are drawn
description: RT. A Journal on Research Policy and Evaluation, Vol 4, No 1 (2016)
A systems perspective on national prioritisation of sustainable development goals: Insights from Australia
Creators: name: Asadikia, Atie
name: Rajabifard, Abbas
name: Kalantari, Mohsen
Publisher: name: Swinburne
Year: 2024

description: Achieving the Sustainable Development Goals (SDGs) requires effective national initiatives and resource allocation. Yet, the simultaneous attainment of all goals is hindered by constraints such as limited budgets and resources, varied national priorities, and the intricate nature of the goals. As we approach 2030 and beyond, an urgent need for an effective, data-driven prioritisation system exists to optimise what can be accomplished. A considerable knowledge gap persists in identifying the priority areas that demand concentrated attention and how their improvement would propel overall sustainability goals. To bridge this gap, our study presents a prioritisation approach that identifies significant SDG indicators based on urgency and impact, utilising Benchmarking, Bivariate, and Network analysis. Furthermore, we introduce an innovative Impact Index (IMIN) to assess an indicator's extensive effect on the SDG network. This system carries significant international relevance by establishing a robust framework to identify key, potent, and interconnected indicators. It supports decision-makers worldwide in comprehending their nation's SDG performance and promotes efficient resource allocation. In the specific context of Australia, our analysis spotlights several impactful, yet underperforming SDG indicators. These include the protection of Freshwater, Terrestrial, and Mountain Key Biodiversity Areas (KBAs), the share of renewable energy and energy intensity level of primary energy, targeted research and development, gender equality in national parliaments, and carbon-efficient manufacturing, amongst others.
Patient and caregiver insights into lung cancer treatment decision-making: an exploratory focus group
Creators: name: Vanderpoel, Julie
name: Imran, Nida
name: Johnson, Andy L.
name: Hutter, Susan
name: Fixler, Karen
name: Holcomb, Christine
name: Peters, Wesley
name: Shea, Lisa
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: We describe discussions about the lung cancer treatment decision-making process across the patient journey from the perspective of patients and caregivers with diverse experiences of living with lung cancer. Patient preference studies show individuals with lung cancer usually favor more aggressive treatments despite adverse events (AEs), in pursuit of better survival. However, patients are frequently passive in treatment decisions, suggesting there are barriers impairing patients’ abilities to engage in shared decision-making. To explore this further, we asked patients with epidermal growth factor receptor-positive lung cancer and their caregivers to complete surveys and participate in focus group discussions facilitated by research specialists. US patients with lung cancer (n = 11) and caregivers (n = 4) took part in exploratory focus groups. While initial treatment decisions were mostly led by healthcare providers, participants became more engaged in their treatment over time. As in other studies, participants prioritized survival over AEs when selecting treatments and shared fears of being switched to less efficacious treatments or reduced dose if they disclosed AEs. Participants emphasized the importance of shared decision-making, early discussions about AEs, and access to patient advocates. Healthcare providers should distribute reliable educational materials and have early conversations with patients on individual lung cancer treatment, health-related quality of life goals, potential AEs, and distinguishing AEs from disease progression symptoms.
Fezolinetant effect on vasomotor symptoms due to menopause in women unsuitable for hormone therapy
Creators: name: Santoro, Nanette
name: Neal-Perry, Genevieve
name: Stute, Petra
name: Blogg, Martin
name: Mancuso, Shayna
name: Morga, Antonia
name: Ottery, Faith D.
name: Siddiqui, Emad
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: To assess efficacy and safety of fezolinetant in women unsuitable for hormone therapy (HT), using pooled SKYLIGHT 1 and 2 data. SKYLIGHT 1 and 2 were double-blind, placebo-controlled studies of once-daily placebo, fezolinetant 30 mg or 45 mg for 12 weeks in women aged ≥40–≤65 years with moderate to severe vasomotor symptoms (VMS; average ≥7 hot flashes/d), followed by a double-blind, non-controlled extension period for 40 weeks. The HT unsuitable group comprised 4 mutually exclusive subgroups, categorized using the following hierarchy: contraindicated; caution; stopper for medical concerns; averse. A total of 1,022 participants received ≥1 dose of study medication (fezolinetant 30 mg, n = 339; fezolinetant 45 mg, n = 341). Improvement was seen for the HT unsuitable group in frequency and severity of moderate to severe VMS from baseline to weeks 4 and 12 (mean difference [95% CI] fezolinetant 45 mg vs. placebo: −2.55; 95% CI, −3.29 to −1.80; p < .001 at week 12). Sleep disturbance, measured by Patient-Reported Outcomes Measurement Information System Sleep Disturbance-Short Form 8b (PROMIS-SD SF 8b) total score, improved by weeks 4 and 12 (mean difference [95% CI] fezolinetant 45 mg vs. placebo at week 12: −1.60; 95% CI, −2.71 to −0.49; p = .005). Fezolinetant was well tolerated in the HT unsuitable group, with treatment-emergent adverse events in 39.4% of participants receiving fezolinetant 45 mg vs. 41.3% receiving placebo. This pooled analysis demonstrated efficacy of fezolinetant vs. placebo in reducing frequency and severity of VMS due to menopause in participants unsuitable for HT. SKYLIGHT 1 – ClinicalTrials.gov, NCT04003155; https://clinicaltrials.gov/ct2/show/NCT04003155 (conducted between July 2019 and August 2021); SKYLIGHT 2 – ClinicalTrials.gov, NCT04003142; https://clinicaltrials.gov/ct2/show/NCT04003142 (conducted between July 2019 and April 2021).
Five-dimensional Yang–Mills black holes in massive gravity’s rainbow
Creators: name: Aounallah, Houcine
name: Pourhassan, Behnam
name: Hendi, Seyed H.
name: Faizal, Mir
Publisher: name: Springer Berlin Heidelberg
Year: 2022

description: In this paper, we will analyze a five-dimensional Yang–Mills black hole solution in massive gravity’s rainbow. We will also investigate the flow of such a solution with scale. Then, we will discuss the scale dependence of the thermodynamics for this black hole. In addition, we study the criticality in the extended phase space by treating the cosmological constant as the thermodynamics pressure of this black hole solution. Moreover, we will use the partition function for this solution to obtain corrections to the thermodynamics of this system and examine their key role in the behavior of corrected solutions.
Additional file 1 of A combination of the K-L and S-P approaches for treating acetabular posterior wall factures accompanied by femoral head fractures with open reduction and internal fixation
Creators: name: Lian, Shichao
name: Yang, Zhong
name: Hu, Zongliang
name: Mu, Weidong
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Imaging data.
The impact of oral anticoagulants on mortality from pneumonia: a propensity score matching analysis
Creators: name: Ryll, Martin J.
name: Aster, Isabell
name: Zodl, Aurelia
name: Thaler, Sarah
name: Rieder, Clemens
name: Tomasi, Roland
name: Groene, Philipp
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Pneumonia continues to be one of the leading causes of death. During the COVID pandemic, pre-existing anticoagulant therapy with direct oral anticoagulants (DOACs) appeared to be beneficial. The present study aimed to investigate the impact of pre-existing DOAC therapy on mortality from community-acquired, non-COVID pneumonia. The study utilized data from the eICU Collaborative Research Database, a comprehensive, multi-institutional critical care database. We included all adult patients with community-acquired pneumonia, selecting for patients with a primary admission diagnosis of pneumonia or pulmonary sepsis who were admitted to the ICU <24 h after admission to the hospital. To adjust for confounders, we performed propensity score matching, matching patients receiving DOACs to an equivalent cohort of patients not receiving DOAC therapy. Our primary outcome was overall survival. Secondary outcomes included all-cause in-hospital mortality, all-cause in-ICU mortality, intubation within 24 h following ICU admission, incidence of acute kidney injury and renal replacement therapy, vasopressor administration, and mechanical ventilation days. Our final matched cohort included 198 DOAC patients matched to 594 patients without DOAC therapy. Survival was significantly higher in DOAC patients with a hazard ratio of 0.56 [95% CI = 0.36–088]. Both all-cause in-unit mortality (6.1% [95% CI = 2.7–9.4%] vs. 13.3% [95% CI = 10.6–16.0%], p = 0.008) and all-cause in-hospital mortality (11.6% [95% CI = 7.2–16.1%] vs. 19.7% [95% CI = 16.5–22.9%], p = 0.013) were significantly lower in patients receiving DOACs. This study demonstrates a positive association between the pre-existing intake of direct oral anticoagulants and the survival of community acquired pneumonia. Future prospective studies should evaluate supportive therapy with DOACs.
Additional file 2 of A combination of the K-L and S-P approaches for treating acetabular posterior wall factures accompanied by femoral head fractures with open reduction and internal fixation
Creators: name: Lian, Shichao
name: Yang, Zhong
name: Hu, Zongliang
name: Mu, Weidong
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Statistical data.
Comparing Flaxseed and Perindopril in the Prevention of Doxorubicin and Trastuzumab-Induced Cardiotoxicity in C57Bl/6 Mice
Creators: name: Eekhoudt, Cameron R.
name: Bortoluzzi, Tessa
name: Varghese, Sonu S.
name: Cheung, David Y. C.
name: Christie, Simon
name: Eastman, Skyler
name: Mittal, Ishika
name: Austria, J. Alejandro
name: Aukema, Harold M.
name: Ravandi, Amir
name: Thliveris, James
name: Singal, Pawan K.
name: Jassal, Davinder S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Background: Two anti-cancer agents, doxorubicin (DOX) and trastuzumab (TRZ), are commonly used in the management of breast cancer in women. Despite their efficacy in reducing the morbidity and mortality of individuals with breast cancer, the use of these agents is limited by adverse cardiotoxic side effects. Both the nutraceutical agent flaxseed (FLX) and the pharmaceutical drug perindopril (PER) have been studied individually in the prevention of chemotherapy-mediated cardiac dysfunction. The objective of this study was to determine whether the prophylactic administration of FLX is comparable and/or synergistic with PER in preventing DOX + TRZ-induced cardiotoxicity. Methods: Over a six-week period, 81 wild-type C57Bl/6 female mice (8–12 weeks old) were randomized to receive regular chow (RC) or 10% FLX-supplemented diets with or without PER (3 mg/kg/week; oral gavage). Starting at week 4, mice were randomized to receive a weekly injection of saline or DOX (8 mg/kg) + TRZ (3 mg/kg). Serial echocardiography was conducted weekly and histological and biochemical analyses were performed at the end of the study. Results: In mice treated with RC + DOX + TRZ, left ventricular ejection (LVEF) decreased from 75 ± 2% at baseline to 37 ± 3% at week 6. However, prophylactic treatment with either FLX, PER, or FLX + PER partially preserved left ventricular systolic function with LVEF values of 61 ± 2%, 62 ± 2%, and 64 ± 2%, respectively. The administration of FLX, PER, or FLX + PER was also partially cardioprotective in preserving cardiomyocyte integrity and attenuating the expression of the inflammatory biomarker NF-κB due to DOX + TRZ administration. Conclusion: FLX was equivalent to PER at preventing DOX + TRZ-induced cardiotoxicity in a chronic in vivo murine model.
Additional file 3 of A combination of the K-L and S-P approaches for treating acetabular posterior wall factures accompanied by femoral head fractures with open reduction and internal fixation
Creators: name: Lian, Shichao
name: Yang, Zhong
name: Hu, Zongliang
name: Mu, Weidong
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3: Table data.
US general population food allergy treatment preferences: a discrete choice experiment
Creators: name: Mickle, Alexis T.
name: Ciaccio, Christina E.
name: Seetasith, Arpamas
name: Johnston, Karissa M.
name: Dunne, Jessica S.
name: Kowal, Stacey
name: Bever, Andrea
name: Ko, Stella
name: Garmo, Vincent
name: Gupta, Sachin
name: Lloyd, Andrew
name: Warren, Christopher M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To quantify treatment preferences for food allergy management options (oral immunotherapy, biologic therapy, and allergen avoidance), overall and by sociodemographic strata. A US general population (≥13 years) discrete choice experiment (DCE) was conducted, including the Intolerance of Uncertainty-12 Scale and clinical/demographic questions. Conditional logistic regression analyses were conducted overall and by sociodemographic factors. DCE results were presented as odds ratios (ORs) with 95% confidence intervals (CIs). Participants (n = 294) mean (standard deviation) age was 47 (19.7) years; 48.6% were male. A 1% reduction in risk of having an exposure resulting in a moderate-to-severe reaction was statistically significantly associated with treatment preference (OR: 1.10; CI:1.04–1.16; p < 0.01). Features significantly associated with reduced preference included: a 1% increase in risk of treatment-related, severe anaphylaxis (0.85; 0.74–0.97; p=0.02); a 1% increase in risk of gastrointestinal symptoms (0.99; 0.99–0.99; p < 0.01); daily treatment (vs. every 2–4 weeks; 0.81; 0.72–0.91; p < 0.01); in-clinic administration (vs. at-home; 0.76; 0.66–0.87; p < 0.01); subcutaneous administration (vs. oral; 0.69; 0.61–0.78; p < 0.01); three-hour post-treatment physical activity limitation (0.84; 0.77–0.93; p < 0.01); and one-year life expectancy reduction (0.87; 0.85–0.89; p < 0.01). Rural dwellers favoured at-home use and no activity limits; lower-income respondents preferred convenience (oral, less frequent, and at-home administration). Teens strongly preferred being bite-safe (vs. fully allergic; 2.75; 1.09–6.90; p = 0.03). When making food allergy management decisions, US general population respondents had strong preferences for features related to safety and convenience; however, the magnitude of preferences varied by sociodemographic factors. These findings may be pertinent for population-level health decision makers.
The impact of oral anticoagulants on mortality from pneumonia – a propensity score matching analysis
Creators: name: Ryll, Martin J.
name: Aster, Isabell
name: Zodl, Aurelia
name: Thaler, Sarah
name: Rieder, Clemens
name: Tomasi, Roland
name: Groene, Philipp
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Pneumonia continues to be one of the leading causes of death. During Covid pandemic pre-existing anticoagulant therapy with direct oral anticoagulants (DOACs) appeared to be beneficial. The present study aimed to investigate the impact of pre-existing DOAC therapy on mortality from community-acquired, non-covid pneumonia. The study utilized data from the eICU Collaborative Research Database, a comprehensive, multi-institutional critical care database. We included all adult patients with community-acquired pneumonia, selecting for patients with a primary admission diagnosis of pneumonia or pulmonary sepsis who were admitted to the ICU <24h after admission to the hospital. To adjust for confounders, we performed propensity score matching, matching patients receiving DOACs to an equivalent cohort of patients not receiving DOAC therapy. Our primary outcome was overall survival. Secondary outcomes included all-cause in-hospital mortality, all-cause in-ICU mortality, intubation within 24h following ICU admission, incidence of acute kidney injury and renal replacement therapy, vasopressor administration and mechanical ventilation days. Our final matched cohort included 198 DOAC patients matched to 594 patients without DOAC therapy. Survival was significantly higher in DOAC patients with a hazard ratio of 0.56 [95% CI: 0.36-088]. Both, all-cause in-unit mortality (6.1% [95%CI: 2.7%-9.4%] vs. 13.3% [95%CI: 10.6%-16.0%], P = 0.008) and all-cause in-hospital mortality (11.6% [95%CI: 7.2%-16.1%] vs. 19.7% [95%CI: 16.5%-22.9%], P = 0.013) were significantly lower in patients receiving DOACs. This study demonstrates a positive association between the pre-existing intake of direct oral anticoagulants and the survival of community acquired pneumonia. Future prospective studies should evaluate supportive therapy with DOACs.
Distributional responses to marine heatwaves: insights from length frequencies across the geographic range of an endemic reef fish
Creators: name: K Cure
name: J-P Hobbs
name: T Langlois
name: D Abdo
name: S Bennett
name: E Harvey
Publisher: name: F1000Research
Year: 2016

description: Evaluation of fish populations at the geographical range level has become necessary, given the increasing number of species range extensions. We present a range-wide assessment of abundance and length-frequency in Choerodon rubescens, a western Australian (WA) endemic species and fisheries target. Our aim was to describe present day patterns and search for evidence of a predicted distributional shift in response to ocean warming. We conducted diver-operated stereo-video surveys at shallow reefs (3-18 m) along 14 locations spanning the entire geographical range of the species (21 to 34° S). Video footage was analysed to obtain fish abundance, length-frequency and habitat structure. Sea surface temperature (SST) was obtained from satellite data. Generalized linear models were used to assess the influence of average temperature (2002-10), heat wave temperature anomaly, habitat, coastal vs. island location, and fisheries protection status, on abundance and length-frequency. Average temperature had the highest effect on C. rubescens abundance patterns. Fish density was highest towards the centre of the temperature gradient investigated (22° C). However, examination of length-frequencies revealed recruitment was highest towards the cooler range edge, and absent at the warmer edge, suggesting a future shift in abundance. Based on recruit length and estimated age, this difference in recruitment occurred during 2011-13 when sea-surface temperature was up to 3° C higher than average. These findings provide empirical support for predictions of a poleward distributional shift in response to ocean warming, and suggest that marine heatwaves can facilitate range shifts by affecting the physiological tolerances of recruits.
Additional file 1 of Preference of caregivers on residential care homes for older persons with versus without communication problems: a discrete choice experiment
Creators: name: Wang, Kailu
name: Wong, Eliza Lai-Yi
name: Lai, Angel Hor-Yan
name: Yam, Carrie Ho-Kwan
name: Ip, Ethan Ming-Yin
name: Cheung, Annie Wai-Ling
name: Yeoh, Eng-Kiong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. A sample choice set for discrete choice experiment. Table S2. Sample characteristics comparison between non-responders and respondents. Table S3. Distribution of communication ability across the 15 DCE blocks. Table S4. Sensitivity analysis: preference for the care home attributes in latent class model. Table S5. Posterior probabilities of class membership and their association with different subgroups. Table S6. MNL model outcomes for preferences according to communication problems. Table S7. MNL model outcomes for preferences according to household income levels. Table S8. MNL model outcomes for preferences according to marital status. Table S9. MNL model outcomes for preferences according to caregiver’s age.
US general population food allergy treatment preferences: a discrete choice experiment
Creators: name: Mickle, Alexis T.
name: Ciaccio, Christina E.
name: Seetasith, Arpamas
name: Johnston, Karissa M.
name: Dunne, Jessica S.
name: Kowal, Stacey
name: Bever, Andrea
name: Ko, Stella
name: Garmo, Vincent
name: Gupta, Sachin
name: Lloyd, Andrew
name: Warren, Christopher M
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: To quantify treatment preferences for food allergy management options (oral immunotherapy, biologic therapy, and allergen avoidance), overall and by sociodemographic strata. A US general population (≥13 years) discrete choice experiment (DCE) conducted comprised of 12 treatment-feature focused DCE choice sets; the Intolerance of Uncertainty─12 Scale (IUS-12); and clinical/demographic questions. Conditional logistic regression analyses were conducted overall and by age, income, urbanization, educational attainment, food and other sociodemographic factors, and presented as odds ratios (ORs) with 95% confidence intervals (CIs). Participants (n = 294) mean (standard deviation) age was 47 (19.7) years; 48.6% were male. Treatment features associated with statistically significant odds against preferring a treatment included: 1% reduction in risk of having an exposure resulting in a moderate-to-severe reaction (tested within a range of 0-10%; OR: 1.10 [CI:1.04-1.16] p < 0.01); treatment-related, severe anaphylaxis (0.85; 0.74-0.97 for a 1% risk); gastrointestinal symptoms (0.99; 0.99-0.99 per +1% risk); daily treatment (versus every 2-4 weeks; 0.81; 0.72-0.91); in-clinic administration (versus at-home; 0.76; 0.66-0.87); subcutaneous administration (versus oral; 0.69; 0.61-0.78); three-hour post-treatment physical activity limitation (0.84; 0.77-0.93); one-year reduction in life expectancy (0.87; 0.85-0.89). Preferences for at-home use and against activity limitations was stronger in rural versus urban dwellers; lower-income respondents strongly preferred convenience-related factors (oral, less frequent, at-home administration). Teens strongly preferred (2.75; 1.09–6.9) being bite-safe (versus fully allergic). When making food allergy management decisions, US general population respondents had strong preferences for features related to safety and convenience; however, the magnitude of preferences varied by sociodemographic factors. These findings may be pertinent for population-level health decision makers.
Additional file 1 of Incorporating interactive workshops into bedside teaching: completion of a multi-modal rheumatology rotation significantly increases internal medicine residents’ competency and comfort with comprehensive knee examinations
Creators: name: Kwiatkowski, Alysia
name: Shakoor, Najia
name: Manadan, Augustine
name: Block, Joel A.
name: Khandelwal, Sonali
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1.
Properties and Applications of Graphene and Its Derivatives in Biosensors for Cancer Detection: A Comprehensive Review
Creators: name: Pourmadadi, Mehrab
name: Soleimani Dinani, Homayoon
name: Saeidi Tabar, Fatemeh
name: Khassi, Kajal
name: Janfaza, Sajjad
name: Tasnim, Nishat
name: Hoorfar, Mina
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Cancer is one of the deadliest diseases worldwide, and there is a critical need for diagnostic platforms for applications in early cancer detection. The diagnosis of cancer can be made by identifying abnormal cell characteristics such as functional changes, a number of vital proteins in the body, abnormal genetic mutations and structural changes, and so on. Identifying biomarker candidates such as DNA, RNA, mRNA, aptamers, metabolomic biomolecules, enzymes, and proteins is one of the most important challenges. In order to eliminate such challenges, emerging biomarkers can be identified by designing a suitable biosensor. One of the most powerful technologies in development is biosensor technology based on nanostructures. Recently, graphene and its derivatives have been used for diverse diagnostic and therapeutic approaches. Graphene-based biosensors have exhibited significant performance with excellent sensitivity, selectivity, stability, and a wide detection range. In this review, the principle of technology, advances, and challenges in graphene-based biosensors such as field-effect transistors (FET), fluorescence sensors, SPR biosensors, and electrochemical biosensors to detect different cancer cells is systematically discussed. Additionally, we provide an outlook on the properties, applications, and challenges of graphene and its derivatives, such as Graphene Oxide (GO), Reduced Graphene Oxide (RGO), and Graphene Quantum Dots (GQDs), in early cancer detection by nanobiosensors.
Additional file 2 of Incorporating interactive workshops into bedside teaching: completion of a multi-modal rheumatology rotation significantly increases internal medicine residents’ competency and comfort with comprehensive knee examinations
Creators: name: Kwiatkowski, Alysia
name: Shakoor, Najia
name: Manadan, Augustine
name: Block, Joel A.
name: Khandelwal, Sonali
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 2.
Rôle de l’expert en écologie halieutique: Elaboration d’un outil d’aide à l’application du protocole de référence pour l’extraction de granulats marins
Creators: name: Vogel, Camille
name: Hebert-Burggraeve, Aurel
name: Dubroca, Laurent
name: Cambreling, Mathis
name: Rivet, Jehanne
name: Brind'Amour, Anik
name: Simplet, Laure
Publisher: name: Ifremer
Year: 2024

description: La pratique de l’expertise est inhérente au travail des scientifiques, dans l’objectif d’éclairer la société et les gestionnaires sur l’état des connaissances et sur les enjeux associés à l’exploitation des milieux marins. Pêche, énergies marines renouvelables, extractions de granulats marins, aménagements portuaires, conchyliculture sont quelques-unes des activités pouvant appeler à cet exercice d’application des connaissances scientifiques dans un cadre administratif. Pour le scientifique lui-même, l’expertise amène à réinterpréter des concepts écologiques dans un contexte donné et contraignant. Ce passage du cadre écologique au cadre administratif, tel que l’évaluation de l’impact potentiel des parcs éoliens sur les populations de poissons, ne permet pas systématiquement d’intégrer la réalité écologique des objets discutés. La distorsion entre la connaissance scientifique et sa prise en compte dans la gestion des écosystèmes marins peut alors générer une perte de sens du travail à accomplir pour l’expert. L’étude du jeu d’acteurs et des attentes de l’ensemble des parties en présence peut permettre d’identifier les points de conflit ou d’incompréhension qui limitent l’efficacité des démarches de concertation mises en œuvre. Dans un contexte de crise écologique, cette analyse pourrait mettre en lumière les limites de l’exercice de la communication scientifique telle qu’elle se pratique aujourd’hui et appeler à de nouvelles initiatives. Pour illustrer ce propos, nous présenterons le cas du protocole de référence halieutique pour le suivi des sites d’extraction de granulats marins. Issu d’une consultation entre l’État, les scientifiques et les industriels, ce protocole a longtemps été contesté en raison du caractère mobile des populations de poissons et d’attentes jugées incompatibles avec le cadre administratif dans lequel il vient s’inscrire. Pour répondre à ces critiques, c’est une démarche avant tout pédagogique qu’il a fallu déployer, aboutissant à la création d’une interface graphique de traitement des données, destinée à aider les industriels et les bureaux d’étude à s’approprier les concepts scientifiques sous-tendant le protocole de référence halieutique.