cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Iranocichla undetermined
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Cichlidae
Iranocichla
Iranocichla undetermined

description: 266. Iranocichla sp.
Common name. Kol cichlid
Taxonomy. This species has yet to be identified to species level (see Schwarzer et al. 2016)
Revisions. None.
Illustrations. Esmaeili et al. (2016b: 154, Fig. 10).
Distribution in Iran. ―Distribution in River Basin: Hormuz.―Distribution in Ecoregions: 451-Northern Hormuz Drainages.
Status in Iran. [Endemic].—Cichlid-e Kol.—Recorded from Iran by Esmaeili et al. (2016); Schwarzer et al. (2016); listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018) and Eagderi et al. (2022).— Iran material: ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on pages 82-83, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Postprandial amino acid response after the ingestion of pea protein, milk protein, casein and a casein–pea blend, in healthy older adults
Creators: name: van Dam, Lotte
name: Kardinaal, Alwine
name: Troupin, Julien
name: Boulier, Audrey
name: Hiolle, Manon
name: Wehrens, Ron
name: Mensink, Marco
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: To identify the potential anabolic properties of a dairy-plant protein blend as compared to single plant-based and single dairy protein, the postprandial amino acid (AA) response of pea protein, milk protein, micellar casein, and a casein–pea protein blend was investigated in healthy older adults (age 72.3 ± 3.4 years, BMI 25.3 ± 2.9 kg/m2). Plasma AA levels were measured, before and up to 5 h after ingestion of each 20 g protein. Blending casein–pea in a 60/40 mixture resulted in improved plasma AA availability, i.e. area under the curve (AUC) and peak height, of total (essential) AA and of key AAs methionine and leucine compared to pea only, while preserving the higher availability of arginine. The casein/pea blend clearly showed an AA response that was in between that of its single constituents, indicating that blending could be a solution to improve a lower quality (plant) protein, which could be of relevance for older adults.
Healthy plant-based diet might be inversely associated with gastric precancerous lesions: new evidence from a case-control study based on dietary pattern and fecal metabolic profiling
Creators: name: Cheng, Wenli
name: Lin, Xiao
name: Wang, Tingting
name: Zhang, Xiaohui
name: Xu, Fang
name: Wang, Li
name: Wang, Min
name: Zhang, Meng
name: Xia, Tao
name: Zhang, Daoming
name: Qian, Shiqing
name: Yang, Wanshui
name: Hu, Anla
name: Tang, Min
name: Hu, Xiangpeng
name: Wang, Yalei
name: Zhao, Qihong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Preventing the progression of gastric precancerous lesions (GPLs) can reduce the morbidity and mortality of gastric cancer (GC). The preventive effect of a plant-based diet on cancers has been widely recognised. In this case–control study, 1,130 subjects were included using 1:1 propensity score matching for age and sex. Dietary habits, anthropometry and sample collection were conducted using standard and effective methods. Plant-based diet indices (PDIs) were calculated using a previously reported method. Faecal samples were analysed by untargeted metabolomics. Our study found that adherence to a healthy plant-based diet was inversely associated with the occurrence of GPLs. Metabolomic analysis identified six different metabolites correlated with GPLs, among which luteolin-related metabolites may be used as biomarkers of the association between PDIs and GPLs. In addition, the difference in N-acyl amides found in PDIs needs further verification. Our findings suggest that a healthy plant-based diet may have a protective effect against GPLs.
Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy
Creators: name: Ojerholm, Eric
name: Kirk, Maura L.
name: Thompson, Reid F.
name: Huifang Zhai
name: Metz, James M.
name: Both, Stefan
name: Ben-Josef, Edgar
name: Plastaras, John P.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Physiology
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Physics

description: Background. Concurrent chemoradiotherapy cures most patients with anal squamous cell carcinoma at the cost of significant treatment-related toxicities. Intensity-modulated radiotherapy (IMRT) reduces side effects compared to older techniques, but whether proton beam therapy (PBT) offers additional advantages is unclear.Material and methods. Eight patients treated with PBT for anal cancer were chosen for this study. We conducted detailed plan comparisons between pencil-beam scanning PBT via two posterior oblique fields and seven-field IMRT. Cumulative dose-volume histograms were analyzed by Wilcoxon signed-rank test, and plan delivery robustness was assessed via verification computed tomography (CT) scans obtained during treatment.Results. Compared to IMRT, PBT reduced low dose radiation (≤ 30 Gy) to the small bowel, total pelvic bone marrow, external genitalia, femoral heads, and bladder (all p < 0.05) without compromising target coverage. For PBT versus IMRT, mean small bowel volume receiving ≥ 15 Gy (V15) was 81 versus 151 cm3, mean external genitalia V20 was 14 versus 40%, and mean total pelvic bone marrow V15 was 66 versus 83% (all p = 0.008). The lumbosacral bone marrow dose was higher with PBT due to beam geometry. PBT was delivered with ≤ 1.3% interfraction deviation in the dose received by 98% of the clinical target volumes.Conclusion. Pencil-beam scanning PBT is clinically feasible and can be robustly delivered for anal cancer patients. Compared with IMRT, PBT reduces low dose radiation to important organs at risk in this population. While the clinical benefit of these differences remains to be shown, existing data suggest that limiting low dose to the small bowel and pelvic bone marrow may reduce treatment toxicity.
Partially Completed Conservation Contracts Reveal On-Farm Practice Incentives
Creators: name: Wallander, Steven
name: Maguire, Kelly B.
name: Wallander, Steven
name: Maguire, Kelly B.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Community/Rural/Urban Development
subject: Environmental Economics and Policy
subject: Farm Management
subject: Land Economics/Use
subject: Environmental Quality Incentives Program (EQIP)
subject: conservation
subject: farmers
subject: ranchers

description: Under USDA’s Environmental Quality Incentives Program (EQIP), farmers and ranchers voluntarily agree to implement specific conservation practices in exchange for technical and financial assistance. Overall, most EQIP contracts were completed as planned—about 80 percent of conservation practices signed in 2010 were completed as originally specified by 2014. For the fifth of practices that were dropped, only about 40 percent occurred where the entire contract was cancelled or terminated.
USDA-Approved Whole-Wheat Bread Package Size Is Now More Common and Less Costly for the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)
Creators: name: McLaughlin, Patrick W.
name: McLaughlin, Patrick W.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Consumer/Household Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: Special Supplemental Nutrition Program
subject: Women, Infants, and Children (WIC)
subject: Federal Dietary Guidelines for Americans

description: In 2009, USDA added 100-percent whole-wheat and whole-grain products to the WIC food packages for women and children. An ERS study found that the WIC-approved 16-ounce package size became more common and less costly relative to other package sizes during 2009-15.
title: The Political Economy of Stranded Assets: Climate Policies, Investments and the Role of Elections
Creators: name: Hagen, Achim
name: Kollenbach, Gilbert
Publisher: name: Hertie School
Year: 2024

description: We study the interaction of climate policies and investments into fossil and renewable energy generation capacity if policies are set by democratically elected governments and can lead to stranded assets. We develop an overlapping generations model, where elections determine carbon taxation and green investment subsidies, and individuals make investments into fossil and renewable capacity. We find that some fossil investments become stranded assets, if the party offering the higher carbon tax is unexpectedly elected. In contrast, if the individuals have perfect foresight, there are no stranded assets, climate damages are fixed and carbon taxation only serves redistributive purposes. Then, there is either no or prohibitive carbon taxation and energy generation completely relies on renewables in the latter case. Green investment subsidies can be used by governments to bind the hands of their successor. If the party representing the young generation is in power, it can use a high subsidy to reduce or even avoid potentially stranded assets in the next period. With endogenous reelection probability, we show that this party can also use investment subsidies strategically to influence the elections. The party that represents the old generation abstains from both types of climate policies to avoid a redistribution of income towards the young generation.
LRIG1 is a prognostic biomarker in non-small cell lung cancer
Creators: name: Kvarnbrink, Samuel
name: Karlsson, Terese
name: Edlund, Karolina
name: Botling, Johan
name: Lindquist, David
name: Jirström, Karin
name: Micke, Patrick
name: Henriksson, Roger
name: Johansson, Mikael
name: Hedman, Håkan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Background. The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins are involved in the regulation of cellular signal transduction. LRIG1 is an endogenous inhibitor of receptor tyrosine kinases (RTKs) and an emerging tumor suppressor. In the lung epithelium, the expression of LRIG1 is downregulated by tobacco smoking, and further downregulated in lung squamous cell carcinoma.Material and methods. The expression of LRIG proteins were analyzed in 347 cases of non-small cell lung cancer (NSCLC) by immunohistochemistry, and LRIG1 mRNA expression was evaluated in 807 lung cancer samples in silico in the Oncomine database. Potential associations between the expression data and the clinical parameters, including patient survival, were investigated.Results. Expression of the LRIG1 protein was found to be an independent prognostic factor in NSCLC, whereas expression of LRIG2 or LRIG3 did not correlate with patient survival. The levels of LRIG1 mRNA also correlated with the survival of NSCLC patients.Conclusion. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with NSCLC that could be important in future decision-making algorithms for adjuvant lung cancer treatment.
The (extra) burden of COVID-19 for people with Parkinson's (Poster)
Creators: name: Noordegraaf, Marina
Publisher: name: Zenodo
Year: 2020
Subjects: Parkinson's
COVID-19
Corona
Parkinson

description: This is the CC BY 4.0. visual interpretation of Marina Noordegraaf (@Sparks4PD) of the article by Bastiaan R. Bloem and Rick C. Helmich. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities. Journal of Parkinson’s Disease 10 (2020) 351–354. https://doi.org/10.3233/JPD-202038 The poster is available in the following languages: English: The (extra) burden of COVID-19 for people with Parkinson's
 Dutch (Nederlands): De (extra) lasten van de COVID-19 pandemie voor mensen met parkinson
 Spanish (espanol): La (extra) carga del COVID-19 en personas con enfermedad de parkinson
 Portuguese (portugues): O Ônus (extra) da COVID-19 para pessoas com parkinson Translations: Spanish and Portuguese translations were provided by the European Parkinson's Disease Association
title: A dynamic neural fields model for spinal motor control
Creators: name: Cefalù, Gabriella
Publisher: name: University of Reading
Year: 2022

description: One of the most debated processes of motor control is how biological systems
solve the degrees of freedom problem, using the redundancy of the motor system
advantageously. Optimisation strategies and control theory result in models that
are task specific and limited at generalising. In this thesis, motor redundancy is
addressed from a biologically inspired perspective, developing a model for spinal
motor control in dynamic field theory (DFT). Empirical studies show that patterns of
muscle activation contribute to coordination, emerging from the integration of cortical
and spinal sensorimotor information. These patterns, called motor primitives, are at
the core of the proposed model and are represented as attractors in two-dimensional
neural fields. Weighted by cortical activations and combined with sensory feedback
carrying the position of the end effector, primitives are combined in a resultant force
field, associated to the motor plan. This process is formalised by a control law that,
giving the forces at the joints of the manipulator, allows for the direct simulation of
the forward dynamics. Other processes in the spinal cord are modelled, including a
neural controller for the autonomous development of the task, an adaptive threshold
enabling stable representations of motor features, and synaptic nodes converting
neural representations into motor variables used to calculate the forces at the next
time-step. Results show a generalised reaching repertoire, emerging from a few
motor primitives and successful straight trajectories, with unimodal velocity profiles.
Introducing two-dimensional traveling peak solutions as elemental behaviour shows
how the developed methodology can be used to add physiologically inspired elements
to cognitive robotics. The findings of this thesis connect existing models in DFT
to biomechanical accounts based on motor primitives, resulting in a fully embodied
account for motor control and opening the way for a unified framework to understand
hand-eye coordination and develop bio-inspired robotics.
Pyroresistive response of percolating conductive polymer composites
Creators: name: Barbieri, Ettore
name: Bilotti, Emiliano
name: Liu, Yi
name: Grimaldi, Claudio
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The pyroresistive response of conductive polymer composites (CPCs) has attracted much interest because of its potential applications in many electronic devices requiring a significant responsiveness to changes in external physical parameters such as temperature or electric fields. Although extensive research has been conducted to study how the properties of the polymeric matrix and conductive fillers affect the positive temperature coefficient pyroresistive effect, the understanding of the microscopic mechanism governing such a phenomenon is still incomplete. In particular, to date, there is little body of theoretical research devoted to investigating the effect of the polymer thermal expansion on the electrical connectivity of the conductive phase. Here, we present the results of simulations of model CPCs in which rigid conductive fillers are dispersed in an insulating amorphous matrix. By employing a meshless algorithm to analyze the thermoelastic response of the system, we couple the computed strain field to the electrical connectedness of the percolating conductive particles. We show that the electrical conductivity responds to the local strains that are generated by the mismatch between the thermal expansion of the polymeric and conductive phases and that the conductor-insulator transition is caused by a sudden and global disconnection of the electrical contacts forming the percolating network.
description: 9 pages with 7 figures: supplemental material: 7 pages with 6 figures
title: Lettre de Jacques Leibowitch à François Jacob
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113419097
THE PROBLEM OF DEFINITION IN MODERN ENGLISH LEXICOGRAPHY
Creators: name: Shukhratova, Shakhina
Publisher: name: Zenodo
Year: 2024

description: Lexicography and lexicology share a common subject of study, but they differ in the extent of organization and comprehensiveness they can attain. This article provides a wide-ranging theoretical overview of lexicography, focusing on the challenges encountered in compiling dictionaries and their presence in English lexicography.
Thrombocytopenia due to low-dose colchicine therapy: A possible drug interaction with nivolumab and implications for supportive care
Creators: name: Solomon, Lawrence R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Science Policy
subject: Cancer
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: Pharmacology
subject: Medicine
subject: Physics
subject: Biophysics

description: Thrombocytopenia due to low-dose colchicine therapy: A possible drug interaction with nivolumab and implications for supportive care
Data Management Plan (Deliverable D7.3)
Creators: name: Comas, Joaquim
name: Atanasova, Natasa
name: Banovec, Primož
name: Wachtel, Thomas
name: Reddy, Suhana
name: Säumel, Ina
Publisher: name: Zenodo
Year: 2019

description: Data Management Plan concern all information that adequately describes and documents the collection, processing, storage, archiving and publication of research data within the framework of a research and or innovation project. The following information focus on how data management is handled within the EdiCitNet project.
description: EdiCitNet has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 776665.
Optimal acceleration voltage for near-atomic resolution imaging of layer-stacked 2D polymer thin films
Creators: name: Baokun Liang
name: Yingying Zhang
name: Leist, Christopher
name: Zhaowei Ou
name: Položij, Miroslav
name: Zhiyong Wang
name: Mücke, David
name: Renhao Dong
name: Zhikun Zheng
name: Heine, Thomas
name: Xinliang Feng
name: Kaiser, Ute
name: Haoyuan Qi
Publisher: name: Zenodo
Year: 2022

description: This repository contains the source data for the manuscript "Optimal acceleration voltage for near-atomic resolution imaging of layer-stacked 2D polymer thin films" Optimized bilayer bulk structures of 2D PI-BPDA and PI-DhTPA under DFTB2+D3(BJ), and corresponding statistical models. A code for building the statistical structure for layered materials by stacking layers following the Maxwell-Boltzmann energy distribution of their stacking modes. Full Changelog: https://github.com/Ying-Ying-Zhang/COFpiler/commits/v1.1
Markion von Sinope - Ablehnung des Alten Testaments und die Antwort der Kirche
Creators: name: Hesping, Steffen Michael
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Theology

description: Diese Hausarbeit untersucht die These des Markion von Sinope, das Alte Testament sei „unchristlich“. Es wird untersucht, wie Markion zu dieser Position gelangt, welches Schriftverständnis er dabei zugrunde legte und wie seinen Lehren begegnet werden kann. Es wird deutlich, dass Markions dualistisches Gottesbild – welches eine klare Trennung zwischen dem strafenden Schöpfergott und dem liebenden Vater Jesu Christi hervorhebt – zu einer radikalen Abkehr von der jüdischen Tradition geführt hat. Seine Position drängte das frühe Christentum, ein eigenständiges Verhältnis zur jüdischen Tradition zu entwickeln und einen verbindlichen Schriftkanon aufzustellen. Die Auseinandersetzung mit Markion steht nicht nur für den Prozess frühchristlicher Identitätssuche, sondern ist auch heute relevant: Sie wirft grundlegende Fragen auf bzgl. des Umgangs mit Vielfalt und Widersprüchen in religiösen Überlieferungen, sowie dem Verhältnis von Geschichte, Glaube und Auslegung.
BOBURIY SHAHZODA MUHAMMAD KOMRON MIRZO HUZURIDAGI ADABIY MAJLISLAR
Creators: name: Sherxon QORAYEV, Qarshi irrigatsiya va agrotexnologiyalar instituti dotsenti (PhD).
Publisher: name: Zenodo
Year: 2024

description: Zahiriddin Muhammad Boburning ikkinchi o‘g‘li temuriy shoir Muhammad Komron Mirzo o‘z she’rlaridan devon tuzgan.[1] Komron Mirzo ham nozik ta’bli ijodkor bo‘lgan.[2] N.Nizomiddinovning yozishicha, “U she’riyatda Nizomiy va turkiy nazmda Navoiyga yetish orzusida ijod etgan, Hindiston turkiyzabon she’riyati bo‘stonida o‘z gulu gulshani, bog‘u bahorini barpo etgan shoir”.[3]

[1] Qorayev Sh. Bobur va Boburiy ijodkorlar tarixi.//International journal of scientific researchers. Impakt Faktor. 7.293. https:// worldyjournals. com/ index. php/ IJSR/ article/view/3286. –Toshkent, Vol.5, No. 2 (2024).-P.763-814.

[2] https://kh-davron.uz/yangiliklar/muborak-kin/bobur-mirzoning-ijodkor-avlodlari..html

[3] Nizomiddinov N. Buyuk boburiylar tarixi. (XVI-XIX asr). T.: Fan va texnologiyalar, 2012.-B.314.
Variation of normal tissue complication probability (NTCP) estimates of radiation-induced hypothyroidism in relation to changes in delineation of the thyroid gland
Creators: name: Rønjom, Marianne F.
name: Brink, Carsten
name: Lorenzen, Ebbe L.
name: Laszlo Hegedüs
name: Johansen, Jørgen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering

description: Background. To examine the variations of risk-estimates of radiation-induced hypothyroidism (HT) from our previously developed normal tissue complication probability (NTCP) model in patients with head and neck squamous cell carcinoma (HNSCC) in relation to variability of delineation of the thyroid gland.Patients and methods. In a previous study for development of an NTCP model for HT, the thyroid gland was delineated in 246 treatment plans of patients with HNSCC. Fifty of these plans were randomly chosen for re-delineation for a study of the intra- and inter-observer variability of thyroid volume, Dmean and estimated risk of HT. Bland-Altman plots were used for assessment of the systematic (mean) and random [standard deviation (SD)] variability of the three parameters, and a method for displaying the spatial variation in delineation differences was developed.Results. Intra-observer variability resulted in a mean difference in thyroid volume and Dmean of 0.4 cm3 (SD ± 1.6) and -0.5 Gy (SD ± 1.0), respectively, and 0.3 cm3 (SD ± 1.8) and 0.0 Gy (SD ± 1.3) for inter-observer variability. The corresponding mean differences of NTCP values for radiation-induced HT due to intra- and inter-observer variations were insignificantly small, -0.4% (SD ± 6.0) and -0.7% (SD ± 4.8), respectively, but as the SDs show, for some patients the difference in estimated NTCP was large.Conclusion. For the entire study population, the variation in predicted risk of radiation-induced HT in head and neck cancer was small and our NTCP model was robust against observer variations in delineation of the thyroid gland. However, for the individual patient, there may be large differences in estimated risk which calls for precise delineation of the thyroid gland to obtain correct dose and NTCP estimates for optimized treatment planning in the individual patient.
Magnetic resonance imaging of the carotid artery in long-term head and neck cancer survivors treated with radiotherapy
Creators: name: Wilbers, Joyce
name: Meijer, Frederick J. A.
name: Kappelle, Arnoud C.
name: Kaanders, Johannes H.
name: Boogerd, Willem
name: Dorresteijn, Lucille D.
name: Dijk, Ewoud J. Van
name: Steens, Stefan C. A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Science Policy
subject: Cancer
subject: Marine Biology
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Engineering

description: Background. In head and neck cancer (HNC) patients, long-term treatment-related complications include radiotherapy (RT)-induced carotid vasculopathy and stroke. The current study investigated the magnetic resonance imaging (MRI) characteristics of the carotid wall in long-term HNC survivors treated with RT.Methods. MRI of the carotid arteries was performed within a prospective cohort of 42 HNC patients on average 7 years after RT. Two independent radiologists assessed maximal vessel wall thickness of common and internal carotid arteries. In case of wall thickening (≥ 2 mm) the MRI signals as well as length of the thickened segment were assessed.Results. Mean (SD) age of the 42 patients at baseline was 53 (13) years and mean (SD) follow-up time after RT was 6.8 (1.3) years. In total 62% were men and 60% had one or more cerebrovascular risk factors. Mean (SD) dose of RT on the common carotid arteries and internal carotid arteries was 57 Gy (11) and 61 Gy (10), respectively. Wall thickening was observed in 58% of irradiated versus 27% of non-irradiated common carotid arteries and 24% of irradiated versus 6% of non-irradiated internal carotid arteries (p < 0.05). Mean (SD) thickness of the irradiated and non-irradiated common carotid arteries was 2.5 (0.9) and 2 (0.7) mm (p = 0.02). Mean thickness of the irradiated and non-irradiated internal carotid arteries was 1.8 (0.8) and 1.5 mm (0.3) (n.s.). Mean length of the thickened vessel wall was 48 mm versus 36 mm in the irradiated versus non-irradiated common carotid arteries (p = 0.03) and 20 mm versus 15 mm in the irradiated versus non-irradiated internal carotid arteries (n.s.). No significant differences were observed for signal intensities of the vessel walls.Conclusions. Our study showed significantly more vessel wall thickening in irradiated versus non-irradiated carotid arteries years after RT for HNC, while no differences in signal intensities were observed.
Harpacticoida (Copepoda) from the pelagic zone of the Sea of Okhotsk: diversity, spatiotemporal distribution, and role in benthopelagic coupling
Creators: name: Chertoprud, Elena S.
name: Frenkel, Svetlana E.
name: Novichkova, Anna A.
name: Sapozhnikov, Philipp V.
name: Kalinina, Olga Y.
name: Chebanova, Victoriya V.
name: Azovsky, Andrey I.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: We analysed the pattern of spatiotemporal distribution of harpacticoid assemblages of 106 plankton samples collected in May–August of 2013–2015 in Prostor Bay, South Kuril Islands (Sea of Okhotsk). Taxonomically and ecologically diverse harpacticoid assemblages were found in the water column. Among the 49 species identified, only one was truly planktonic, while the others were typically benthic, mainly phytal-dwelling forms. The most abundant and rich (42 species) assemblage occupied the shallow (10 m depth) area in the western, stone-bottomed part of the bay with a well-developed phytal zone. In deeper areas, the abundance and diversity of harpacticoids in plankton samples decreased steeply. There was a clear seasonal pattern of abundance, diversity and composition, with a peak in spring and then a decrease. On average, the total abundance was low (64 ind/m2). Neither interannual variations contributed significantly to the harpacticoid distribution. The analysis of the gut contents suggests that the harpacticoids feed on planktonic diatoms in the water column, but their residence time in the water column was short, and their feeding rate was low. In turn, the harpacticoids constituted a permanent but relatively minor fraction of the salmon fry diet. Thus, in quantitative terms, harpacticoids contribute relatively little to benthopelagic coupling in the Prostor Bay ecosystem.
Supplementary Material, Isanta-Navarro et al. from A sterol-mediated gleaner-opportunist trade-off underlies the evolution of grazer resistance to cyanobacteria
Creators: name: Isanta-Navarro, Jana
name: Klauschies, Toni
name: Wacker, Alexander
name: Martin-Creuzburg, Dominik
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The human-caused proliferation of cyanobacteria severely impacts consumers in freshwater ecosystems. Toxicity is often singled out as the sole trait to which consumers can adapt, even though cyanobacteria are not necessarily toxic and the lack of nutritionally critical sterols in cyanobacteria is known to impair consumers. We studied the relative significance of toxicity and dietary sterol deficiency in driving the evolution of grazer resistance to cyanobacteria in a large lake with a well-documented history of eutrophication and oligotrophication. Resurrecting decades-old Daphnia genotypes from the sediment allowed us to show that the evolution and subsequent loss of grazer resistance to cyanobacteria involved an adaptation to changes in both toxicity and dietary sterol availability. The adaptation of Daphnia to changes in cyanobacteria abundance revealed a sterol-mediated gleaner-opportunist trade-off. Genotypes from peak-eutrophic periods showed a higher affinity for dietary sterols at the cost of a lower maximum growth rate, whereas genotypes from more oligotrophic periods showed a lower affinity for dietary sterols in favour of a higher maximum growth rate. Our data corroborate the significance of sterols as limiting nutrients in aquatic food webs and highlight the applicability of the gleaner-opportunist trade-off for reconstructing eco-evolutionary processes.
Main Supplement from Geographically diverse canid sampling provides novel insights into pre-industrial microbiomes
Creators: name: Yarlagadda, K.
name: Zachwieja, A. J.
name: de Flamingh, A.
name: Phungviwatnikul, T.
name: Rivera-Colón, A. G.
name: Roseman, C.
name: Shackelford, L.
name: Swanson, K. S.
name: Malhi, R. S.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 60408 Genomics

description: Contains additional tables, figures, and text referenced in the main text
Dose-dependent modulation of myogenesis by HGF: implications for c-Met expression and downstream signalling pathways
Creators: name: Walker, Nicholas
name: Kahamba, Trish
name: Woudberg, Nicholas
name: Goetsch, Kyle
name: Niesler, Carola
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physiology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Hepatocyte growth factor (HGF) regulates satellite cell activation, proliferation, and differentiation. We analyzed the dose-dependent effects of HGF on myogenesis. Murine C2C12 and human donor-derived skeletal muscle myoblasts were treated with 0, 2, or 10 ng/ml HGF followed by assessment of proliferation and differentiation. HGF (2 ng/ml) significantly promoted cell division, but reduced myogenic commitment and fusion. Conversely, 10 ng/ml HGF reduced proliferative capability, but increased differentiation. c-Met expression analysis revealed significantly decreased expression in differentiating cells cultured with 2 ng/ml HGF, but increased expression in proliferating cells with 10 ng/ml HGF. Mitogen-activated protein kinase (MAPKs: ERK, JNK, or p38K) and phosphatidylinositol-3-kinase (PI3K) inhibition abrogated the HGF-stimulated increase in cell number. Interestingly, PI3K and p38 kinase facilitated the negative effect of HGF on proliferation, while ERK inhibition abrogated the HGF-mediated decrease in differentiation. Dose-dependent effects of HGF are mediated by changes in c-Met expression and downstream MAPK and PI3K signalling.
Synthesis and DNA studies of a copper(II) complex of 5,6-dihydro-5,6-epoxy-1,10-phenanthroline
Creators: name: Sekar Baskaran
name: Krishnan, Mani Murali
name: Mahadevimangalam Narayanasamy Arumugham
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Molecular Biology
Physics
Engineering
Biochemistry
Biophysics

description: A new copper(II) complex, [Cu(epoxy)(phen)(NO3)](NO3)·H2O (epoxy = 5,6-dihydro-5,6-epoxy-1,10-phenanthroline, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, IR and UV–vis spectroscopy, and single crystal X-ray diffraction. The complex crystallized in a monoclinic system with space group P21/n, a = 13.3199(8) Å, b = 11.2917(7) Å, c = 16.0832(9) Å, α = 90°, β = 107.827(4)°, and γ = 90°. The complex cation possesses a distorted octahedral geometry, with Jahn–Teller distortion occurring in the CuN4O2 core. The binding interaction with calf thymus DNA (CT–DNA) was investigated by UV–vis and fluorescence spectroscopy, cyclic voltammetry, and viscometry. The results support a partially intercalative binding mode. Efficient cleavage of plasmid DNA by the complex was observed by gel electrophoresis.
Study of mutation and misfolding of Cu-Zn SOD1 protein
Creators: name: P. Kolandaivel
name: S.P. Keerthana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Physics
Biochemistry
Biophysics

description: The main objective of this work is to determine the mechanism for misfolding and aggregation as a result of mutations in Cu-Zn superoxide dismutase1. The quantum mechanical approach is beneficial for investigating the early stages of mutation, misfolding, and loss of protection of the native structures involved in the neuro-degeneration disease Amyotrophic Lateral Sclerosis. All the structures were optimized using density functional theory (B3LYP) with 6–31G* and LANL2DZ basis sets. The binding energies of the metal ions with their associated residues in the active site loop and metal binding loop have been investigated for native and metal-bound mutated structures. The metal ion affinity (MIA) was computed for all the structures. The binding energy and MIA in gas phase reveal the nature of interaction of active site residues with the metal cations. The electronic effect prevailing between the side chains of the residues in the active site governing the intermolecular interactions is given by the polarizability studies. The role of the bridging residue His 63 in the active site of the protein in the native and metal-bound mutated structures have been studied using ONIOM method to reveal the changes that takes place in the structural parameters during mutation. The molecular dynamics simulation is used to explore different dynamic properties of active site in native and metal-bound mutated structures. The structural information provided by the molecular dynamics simulation illustrates the structural consequences in the mutated structures.
Specific activation, signalling and secretion profiles of human platelets following PAR-1 and PAR-4 stimulation
Creators: name: Nguyen, Kim Anh
name: Hamzeh-Cognasse, Hind
name: Laradi, Sandrine
name: Pozzetto, Bruno
name: Garraud, Olivier
name: Cognasse, Fabrice
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Blood platelets play a central haemostatic function; however, they also play a role in inflammation and are capable of secreting various cytokines, chemokines and related products. The purpose of this study was to identify subtle variations in platelet physiology using proteomics. We compared the levels of membrane proteins (n = 3), α and δ granule proteins (n = 18), and signalling proteins (n = 30) from unstimulated platelets with those of protease-activated receptor (PAR)-1- and PAR-4-stimulated platelets (n = 10). The vast majority of these proteins responded similarly to PAR-1 or PAR-4 engagement. However, differences were observed within membrane CD40L expressed, and α granule GRO-α and MDC secreted proteins.
CORDEX-FPS AEROSOL : submitted proposal
Creators: name: Solmon, Fabien
name: Mallet, Marc
Publisher: name: Zenodo
Year: 2021
Subjects: CORDEX
RCM
Mediterranean
regional
aerosol
coupling
climate
Europe

description: This document is the submitted version of the proposal of the CORDEX Flagship Pilot Study on Aerosol (CORDEX FPS-aerosol). It describes the proposed activities of the CORDEX FPS-aerosol initiative concerning the "Role of the natural and anthropogenic aerosols in the Mediterranean region: past climate variability and future climate sensitivity". The proposal, leaded by F. Solmon and M. Mallet, was submitted in February 2016 and endorsed by the CORDEX Science Advisory Team in May 2016. The CORDEX FPS-aerosol contributes to the MISTRALS/ChArMEX programme and to the Med-CORDEX phase 2.
Effect of training status on the changes in platelet parameters induced by short–duration exhaustive exercise
Creators: name: Alis, Rafael
name: Sanchis-Gomar, Fabian
name: Risso-Ballester, Jennifer
name: Blesa, Jose R.
name: Romagnoli, Marco
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology

description: It is now well known that hemostasis is directly involved in the benefits induced by physical activity. It has recently been shown that the baseline mean platelet volume (MPV) may be a predictor of endurance performance. We aimed to explore whether platelet parameters are associated with VO2max as well as running duration and speed in a short-duration exhaustive exercise test. Thirty healthy male subjects (10 sedentary and 20 trained) performed an incremental running test until exhaustion. MPV, platelet distribution width (PDW), platelet (Plt) count, and plateletcrit (Pct) were determined before exercise, immediately after exercise and after 30′ recovery. Training status did not produce any difference in the baseline levels or in the post-exercise increases found in all the parameters tested. VO2max, test duration, and running speed were not correlated with any baseline parameter. Although MPV was found to be a predictor of endurance performance in long-duration exercise, the results of the present study are consistent with the hypothesis that MPV may not be a significant marker of performance in short-duration exhaustive exercise. Likewise, more research is needed to ascertain whether platelet activation is a reliable performance predictor in other exercise settings.
3D shape sensor plane based on a flexible glass foil
Creators: name: Koch, Jannis
Publisher: name: Zenodo
Year: 2024

description: This demonstrator is about the Deliverable D5.5 of Work Package 5 of the FleX-RAY project. The main part ofthis deliverable is a video in which the 3D shape sensor based on ultra-thin glass is demonstrated. Thepurpose of the sensor within the project is to measure the 3D shape of the X-ray detector to obtain thedetector geometry, which is necessary for the image reconstruction.The video demonstration features a presentation of the ultra-thin glass 3D shape sensor in a 3-point bendingsetup. The main characteristics of the ultra-thin glass 3D shape sensor are explained. In combination with acomputer algorithm, the shape is recalculated reliably and displayed on a screen.

 

This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 899634.
Conservation genetics of high-arctic Gull species at risk: I. Diversity in the mtDNA control region of circumpolar populations of the Endangered Ivory Gull (Pagophila eburnea)
Creators: name: Royston, Stephanie R.
name: Carr, Steven M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology

description: The high-arctic Ivory Gull (Pagophila eburnea) has recently undergone a sharp decline in numbers, and in Canada it is listed as “Endangered” under the Species-At-Risk Act. To test for circumpolar genetic distinctiveness, we examined 264 bp of the mtDNA Control Region Domain I from 127 museum specimens collected during the breeding season from northern Canada, Greenland, and Norway, and during the non-breeding season from adjacent overwintering grounds in Canada, Greenland, and a disjunct area in Alaska adjacent to the Bering Sea. Partition of genetic variance according to various phylogeographic and breeding ground models indicates no strong population structure, except that Alaska birds are consistently differentiated from other locations, and there are significant temporal shifts in haplotype frequencies. The evidence suggests that Ivory Gulls in Canada, Greenland, and Norway are a single genetic entity, in contrast to Alaska birds, which may represent a distinctive Siberian population.
Effect of training status on the changes in platelet parameters induced by short–duration exhaustive exercise
Creators: name: Alis, Rafael
name: Sanchis-Gomar, Fabian
name: Risso-Ballester, Jennifer
name: Blesa, Jose R.
name: Romagnoli, Marco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology

description: It is now well known that hemostasis is directly involved in the benefits induced by physical activity. It has recently been shown that the baseline mean platelet volume (MPV) may be a predictor of endurance performance. We aimed to explore whether platelet parameters are associated with VO2max as well as running duration and speed in a short-duration exhaustive exercise test. Thirty healthy male subjects (10 sedentary and 20 trained) performed an incremental running test until exhaustion. MPV, platelet distribution width (PDW), platelet (Plt) count, and plateletcrit (Pct) were determined before exercise, immediately after exercise and after 30′ recovery. Training status did not produce any difference in the baseline levels or in the post-exercise increases found in all the parameters tested. VO2max, test duration, and running speed were not correlated with any baseline parameter. Although MPV was found to be a predictor of endurance performance in long-duration exercise, the results of the present study are consistent with the hypothesis that MPV may not be a significant marker of performance in short-duration exhaustive exercise. Likewise, more research is needed to ascertain whether platelet activation is a reliable performance predictor in other exercise settings.
Synthesis and Characterization of Novel Organic Heteroatom Compounds from Reaction of Woollins' Reagent with Various Organic Substrates
Creators: name: Guoxiong Hua
name: Junyi Du
name: Cordes, David B.
name: Kasun S. A. Arachchige
name: Slawin, Alexandra M. Z.
name: J. Derek Woollins
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Biochemistry

description: A series of new selenium-containing heteroatom compounds were synthesized in good yields by the reactions of Woollins' reagent with various organic substrates such as cyclohexylamine, N-benzoylbenzamide, benzoic anhydride, 4-fluoro-N-(2-oxo-2-phenylethyl)benzamide, N-benzoylbenzamide, benzoic anhydride, 3-(bromomethyl)benzonitrile, 1,2-diphenylethane-1,2-diol and sodium alcoholate. Three representative X-ray structures are described.