cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy : early detection of response in head and neck cancer patients
Creators: name: Theodoraki, M.-N.
name: Laban, S.
name: Jackson, E. K.
name: Lotfi, R.
name: Schuler, P. J.
name: Brunner, C.
name: Hoffmann, T. K.
name: Whiteside, T. L.
name: Hofman, L.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Head and neck cancer
subject: Tumour immunology
subject: DDC 610 / Medicine & health
subject: Head and neck neoplasms
subject: Head and neck neoplasms; Immunology
subject: Molecular diagnostic techniques
subject: Hals-Nasen-Ohren-Tumor
subject: Tumorimmunologie

description: Background Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their cargo correlates with clinical parameters. Here, we evaluated the exosomal molecular profile for early detection of treatment failure in locally advanced HNSCC patients treated with conventional therapy. Methods Plasma from 17 HNSCC patients was collected before, during, and after treatment by surgery with adjuvant (chemo)radiation and at recurrence. Exosomes were isolated by size-exclusion chromatography. Total exosomal protein (TEP) was used to estimate exosome load and on-bead flow cytometry to evaluate relative fluorescence intensity (RFI) of tumour-associated and immunoregulatory proteins on exosomes. Exosomal effects on the activity of and adenosine production by T cells was assessed by flow cytometry and mass spectrometry. Results TEP and the ratio of tumour-/immune-cell-derived exosomes varied during and after therapy with an overall decrease in the tumour-free follow-up but an increase at recurrence. RFI values of immunoregulatory proteins on exosomes, their ability for T cell inhibition and adenosine production changed during and after therapy. PD-L1 was the earliest discriminator for treatment failure and disease-free survival. Conclusions Monitoring of plasma exosomes during therapy represents a promising opportunity for early detection of treatment failure and risk stratification to delay/avoid recurrence.
title: Ð¢Ð°Ð¼Ð¾Ð¶ÐµÐ½Ð½Ð¾Ðµ Ð´ÐµÐ»Ð¾
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: Ð¤ÐµÐ´Ð¾ÑÐ¾Ð²Ð°, ÐÐ°Ð»Ð¸Ð½Ð°
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024

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title: OFROM: interview avec unine15a31m
Creators: name: Delafontaine, François
name: Ehinger, Maude
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.e4023082.v2#f4affc201dc29b42acbe9f33d2dfbabbb8686db7
Pd-modified De-alloyed Au−Ni-microelectrodes for in situ and operando mapping of hydrogen evolution
Creators: name: Kund, Julian
name: Romer, Jan
name: Oswald, Eva
name: Gaus, Anna-Laurine
name: Küllmer, Maria
name: Turchanin, Andrey
name: Von Delius, Max
name: Kranz, Christine
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Co-based HER catalysts
subject: Pd-modified de-alloyed Au−Ni microelectrodes
subject: Electrochemical H2 measurements
subject: SECM
subject: DDC 540 / Chemistry & allied sciences
subject: Scanning electrochemical microscopy
subject: Rasterelektrochemisches Mikroskop

description: To date most studies focusing on light-driven water splitting for green energy conversion schemes depend on bulk analyses of the produced hydrogen using, e. g., head-space gas chromatography. In this contribution, we present the fabrication of Pd-modified microelectrodes for in situ electrochemical hydrogen measurements using de-alloyed Au−Ni microelectrodes. Stability studies and pH-dependent investigations revealed the stability of these microsensors over a period of seven days, and confirmed their applicability in a pH range of 3–10 with a limit of detection (LOD)<1 μmol/L. First in situ proof-of-principle electrochemical imaging of hydrogen generated at a microelectrode and operando studies of hydrogen evolution at earth-abundant cobalt hydrogen evolution catalysts using the developed Pd-microsensors in combination with scanning electrochemical microscopy (SECM) demonstrated the potential of these microsensors for operando studies in light-driven heterogeneous catalysis.
BIO205 2016 Tut0104 Census 2 Data.xlsx
Creators: name: Richter, Christoph
Publisher: name: figshare
Year: 2016
Subjects: subject: 60202 Community Ecology (excl. Invasive Species Ecology)
subject: FOS: Biological sciences
subject: 60299 Ecology not elsewhere classified
subject: 60207 Population Ecology
subject: 60208 Terrestrial Ecology

description: Data set collected at University of Toronto Mississauga (UTM) campus, following protocol posted at http://www.campusecology.network/protcol/
On the economic value of the agronomic effects of crop diversification for farmers: estimation based on farm cost accounting data
Creators: name: Sodjahin, Ibirénoyé Honoré Romaric
name: Féménia, Fabienne
name: Koutchade, Obafémi Philippe
name: Carpentier, Alain
name: Sodjahin, Ibirénoyé Honoré Romaric
name: Féménia, Fabienne
name: Koutchade, Obafémi Philippe
name: Carpentier, Alain
Publisher: name: Unknown
Year: 2022
Subjects: subject: Crop Production/Industries
subject: Production Economics
subject: Research Methods/ Statistical Methods
subject: crop rotation effects
subject: crop diversification
subject: endogeneity
subject: random parameter
subject: SAEM
subject: algorithm

description: Despite many benefits provided by diversified cropping systems, there is a dearth of empirical evidence on the economic relevance of their effects, mainly due to lack of information on the dynamics of farmers’ crop acreages. Our article contributes to fill this gap and, thereby, to shed light on a pair of apparently contradictory facts. European farmers tend to stick to specialized crop acreages despite agronomic experiments tending to show that crop diversification could reduce chemical input uses while maintaining or even enhancing arable crop yield levels We provide estimates of the effects of previous crops and crop acreage diversity on yield and chemical input use levels based on a sample of 769 arable crop producers covering the Marne département in France from 2008 to 2014. Our farm level dataset combines cost accounting data, information on crop sequences as well as detailed soil and weather data. Our estimation approach relies on yield functions and input use models defined as systems of simultaneous equations. These models feature farm specific random parameters for accounting for unobserved heterogeneity across farms and farmers as well as for accommodating input use endogeneity in the considered empirical crop yield functions. We estimate pre crop and crop acreage diversity effects for four major crops in the area. Pre crops effects on yields are estimated relatively accurately and are generally consistent with the rankings provided by crop production experts. Estimated pre crop effects on input uses are small and insignificant from a statistical viewpoint despite our large sample, suggesting that pre crops don’t impact much chemical input requirements or/and that farmers tend to downplay these effects when deciding their chemical input use levels. Our results also show that crop acreage diversity positively impacts yield levels and tend to induce reductions in pesticide uses, herbicide uses in particular. Overall, our results demonstrate statistically significant though economically limited effects of pre crops and crop acreage diversity on crop gross margins. They also suggest that policy measures aimed to foster crop diversification are unlikely to significantly reduce chemical input uses on major crops if they are not supplemented by measures specifically aimed to reduce the uses of these inputs.
BIO205 2016 Tut0104 Census 1 Data.xlsx
Creators: name: Richter, Christoph
Publisher: name: figshare
Year: 2016
Subjects: subject: 60202 Community Ecology (excl. Invasive Species Ecology)
subject: FOS: Biological sciences
subject: 60299 Ecology not elsewhere classified
subject: 60207 Population Ecology
subject: 60208 Terrestrial Ecology

description: Data set collected at University of Toronto Mississauga (UTM) campus, following protocol posted at http://www.campusecology.network/protcol/
Algorithmic Price Discrimination and Consumer Protection
Creators: name: Grochowski, Mateusz
name: Jabłonowska, Agnieszka
name: Lagioia, Francesca
name: Sartor, Givanni
Publisher: name: Technology and Regulation
Year: 2022

description: This paper investigates the practice of algorithmic price discrimination with a view to determining its impact on markets and society and making a possible plea for regulation. Online market players are gradually gaining the capacity to adapt prices dynamically based on knowledge generated through vast amounts of data, so that, theoretically, every individual consumer can be charged the maximum price he or she is willing to pay. The article discusses the downsides of data-driven price discrimination. It considers the extent to which such downsides are mitigated by European Union law, and what role remains for national provisions and consumer-empowering technologies. We find that the existing EU provisions address price discrimination only marginally and that full harmonisation, a goal pursued through many acts regulating consumer markets, restricts the Member States’ margin for independent legislation. Accordingly, consumer protection against algorithmic pricing may rely, in practice, on consumer-empowering technologies and initiatives. We investigate the implications of this state of affairs, arguing that an unbalanced “digital arms race” between the use of algorithms as market devices on the one hand, and their use as consumer protection tools on the other, does not ensure consumer protection. Based on these findings, we advance a claim for regulation which pursues two main goals: first, to make the race more balanced by strengthening the digital tools available to consumer protection actors and, second, to limit the battlefield by clarifying and refining the applicable rules and defining clearer categories of impermissible behaviours.
description: Technology and Regulation, Vol. 2022 (2022)
Pretrained blastocysts live birth prediction model
Creators: name: Yu, Lu
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 321502
subject: Obstetrics and gynaecology
classificationCode: 461104
subject: Neural networks
classificationCode: 460102
subject: Applications in health

description: Blastocysts live birth prediction model pretrained on post-warmed blastocyst static images
Understanding instructional design effects by differentiated measurement of intrinsic, extraneous, and germane cognitive load
Creators: name: Klepsch, Melina
name: Seufert, Tina
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Cognitive load theory
subject: Differentiated measurement
subject: Multimedia research
subject: Multimedia design principles
subject: Disfluency
subject: Principles
subject: Examples
subject: DDC 150 / Psychology
subject: Educational psychology
subject: Learning
subject: Instructional design
subject: Pädagogische Psychologie
subject: Lernen
subject: Kognitiver Prozess

description: Instructional design deals with the optimization of learning processes. To achieve this, three aspects need to be considered: (1) the learning task itself, (2) the design of the learning material, and (3) the activation of the learner’s cognitive processes during learning. Based on Cognitive Load Theory, learners also need to deal with the task itself, the design of the material, and the decision on how much to invest into learning. To link these concepts, and to help instructional designers and teachers, cognitive load during learning needs to be differentially measured. This article reviews studies using a questionnaire to measure intrinsic, extraneous and germane cognitive load in order to provide evidence for the instruments’ prognostic validity. Six exemplary studies from different domains with different variations of the learning material were chosen to show that the theoretically expected effects on different types of load are actually reflected in the learners’ answers in the questionnaire. Major hypotheses regarding the different load types were (1) variations in difficulty are reflected in the scale on intrinsic cognitive load, (2) variations in design are reflected in the scale on extraneous cognitive load, and (3) variations in enhancing deeper learning through activation of cognitive processes are reflected in the scale on germane cognitive load. We found prognostic validity to be good. The review concludes by discussing the practical and theoretical implications, as well as pointing out the limitations and needs for further research.
Clinical characterization of children and adolescents with NF1 microdeletions
Creators: name: Kehrer-Sawatzki, Hildegard
name: Kluwe, Lan
name: Salamon, Johannes
name: Well, Lennart
name: Farschtschi, Said
name: Rosenbaum, Thorsten
name: Mautner, Victor-Felix
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Neurofibromatosis type 1
subject: NF1 microdeletion
subject: Cognitive impairment
subject: Attention deficit hyperactivity disorder (ADHD)
subject: DDC 610 / Medicine & health
subject: Neurofibromatosis 1
subject: Neurofibroma
subject: Autism spectrum disorder
subject: Attention deficit disorder with hyperactivity
subject: Cognitive dysfunction
subject: Neurofibromatose
subject: Autismus
subject: Aufmerksamkeitsdefizit-Syndrom
subject: Kognitive Störung

description: Purpose An estimated 5–11% of patients with neurofibromatosis type 1 (NF1) harbour NF1 microdeletions encompassing the NF1 gene and its flanking regions. The purpose of this study was to evaluate the clinical phenotype in children and adolescents with NF1 microdeletions. Methods We retrospectively analysed 30 children and adolescents with NF1 microdeletions pertaining to externally visible neurofibromas. The internal tumour load was determined by volumetry of whole-body magnetic resonance imaging (MRI) in 20 children and adolescents with NF1 microdeletions. Furthermore, the prevalence of global developmental delay, autism spectrum disorder and attention deficit hyperactivity disorder (ADHD) were evaluated. Results Children and adolescents with NF1 microdeletions had significantly more often cutaneous, subcutaneous and externally visible plexiform neurofibromas than age-matched patients with intragenic NF1 mutations. Internal neurofibromas were detected in all 20 children and adolescents with NF1 microdeletions analysed by whole-body MRI. By contrast, only 17 (61%) of 28 age-matched NF1 patients without microdeletions had internal tumours. The total internal tumour load was significantly higher in NF1 microdeletion patients than in NF1 patients without microdeletions. Global developmental delay was observed in 28 (93%) of 30 children with NF1 microdeletions investigated. The mean full-scale intelligence quotient in our patient group was 77.7 which is significantly lower than that of patients with intragenic NF1 mutations. ADHD was diagnosed in 15 (88%) of 17 children and adolescents with NF1 microdeletion. Furthermore, 17 (71%) of the 24 patients investigated had T-scores ≥ 60 up to 75, indicative of mild to moderate autistic symptoms, which are consequently significantly more frequent in patients with NF1 microdeletions than in the general NF1 population. Also, the mean total T-score was significantly higher in patients with NF1 microdeletions than in the general NF1 population. Conclusion Our findings indicate that already at a very young age, NF1 microdeletions patients frequently exhibit a severe disease manifestation which requires specialized long-term clinical care.
Supplementary Table 2. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Gene set enrichment analysis of Rop7-II versus Rop7-III. GeneGo Metacore Biological processes found to be enriched (FDR≥0.01) with genes that were significantly differentially expressed between Rop7-II and Rop7-III CD8 T cells.
Supplementary Figure 2. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Parasite load was assessed by in vivo luminescence after adoptive transfer of 8x104 sorted Rop7-I, -II and -III CD8 T cells and infection intraperitoneally with 5x104 Pru luciferase parasites on days 4, 5, 6 and 7 post-infection. No significant difference in parasite load was observed.
Supplementary Figure 1. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Histograms show Rop7 tetramer staining on splenic CD4 cells from WT, Rop7-I, -II and -III mice.
Intraoperative bacterial cultures fail to reliably predict the bacterial spectrum encountered during infectious complications after appendicitis
Creators: name: Strohäker, Jens K. H.
name: Brüschke, Martin J.
name: Bachmann, Robert
name: Mihaljevic, André L.
name: Ladurner, Ruth
name: Beltzer, Christian R.
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Acute appendicitis
subject: Complicated appendicitis
subject: Intraabdominal abscess
subject: Antibiotic stewardship
subject: Medical and Health Sciences
subject: DDC 610 / Medicine & health

description: Abstract Acute appendicitis is a common surgical emergency. Complicated appendicitis usually warrants perioperative antibiotic treatment in order to prevent infectious complications. Whether routine microbiological testing benefits the individual patient is a topic of debate. The goal of our study was to assess perioperative antibiotic prescriptions as well as the benefit of microbiological testing during the appendectomy as a predictor for bacteria encountered in infectious complications. This is a retrospective analysis of 1218 consecutive patients that underwent appendectomy at a tertiary referral center between 2014 and 2021. The patient charts were systematically analyzed regarding intraoperative outcome, microbiologic results, and postoperative infectious complications. 1218 patients were included in this study of which 768 were uncomplicated appendicitis (UA) and 450 were complicated appendicitis (CA). Microbiological testing was performed in 39.2% of UA cases (33.6% of which grew bacteria) compared to 74.9% of CA cases (78.6% positive cultures). The strongest individual predictors for SSI were gangrenous and perforated appendicitis. A total of 58 surgical-site infections developed, of which 49 were intra-abdominal fluid collections or abscesses. Thirty-two patients had revision surgery or CT-guided drainage for SSI. In the cases where microbiological testing was done both during the appendectomy and the SSI, 13/18 showed different bacteria on culture testing. The infectious outcome was favorable in 98.3%. While microbiological testing offers insights into resistance patterns, it is of little benefit for the individual patient, given the low predictive value for bacteria found during SSI. Achieving source control combined with empiric antibiotic coverage leads to favorable outcomes independent of culture results. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Excavations and Survey at Piel Castle, near Barrow-in-Furness, Cumbria.
Creators: name: Newman, Rachel
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 101-116
description: Records a major project of excavation and survey of the keep within the inner ward. Fabric survey suggests a sequence of building. The 'chapel' in the outer bailey may be post-occupation. Heavy reconstruction in 19th century adds to complexities.
Supplementary Table 1. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: The transcriptional profile of Rop7-III compared to that of Rop7-II. 115 genes were identified to be significantly expressed with at least a two-fold difference.
Contrasting dedicated model transformation languages versus general purpose languages : a historical perspective on ATL versus Java based on complexity and size
Creators: name: Höffner, Stefan
name: Kehrer, Timo
name: Tichy, Matthias
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Model transformations
subject: Model transformation language
subject: General purpose language
subject: MTL versus GPL
subject: Complexity measure
subject: Size measure
subject: DDC 004 / Data processing & computer science
subject: Java
subject: Comparison
subject: Historical perspectives
subject: Complexity (Philosophy)
subject: ATL (Programm)
subject: Komparation

description: Model transformations are among the key concepts of model-driven engineering (MDE), and dedicated model transformation languages (MTLs) emerged with the popularity of the MDE pssaradigm about 15 to 20 years ago. MTLs claim to increase the ease of development of model transformations by abstracting from recurring transformation aspects and hiding complex semantics behind a simple and intuitive syntax. Nonetheless, MTLs are rarely adopted in practice, there is still no empirical evidence for the claim of easier development, and the argument of abstraction deserves a fresh look in the light of modern general purpose languages (GPLs) which have undergone a significant evolution in the last two decades. In this paper, we report about a study in which we compare the complexity and size of model transformations written in three different languages, namely (i) the Atlas Transformation Language (ATL), (ii) Java SE5 (2004–2009), and (iii) Java SE14 (2020); the Java transformations are derived from an ATL specification using a translation schema we developed for our study. In a nutshell, we found that some of the new features in Java SE14 compared to Java SE5 help to significantly reduce the complexity of transformations written in Java by as much as 45%. At the same time, however, the relative amount of complexity that stems from aspects that ATL can hide from the developer, which is about 40% of the total complexity, stays about the same. Furthermore we discovered that while transformation code in Java SE14 requires up to 25% less lines of code, the number of words written in both versions stays about the same. And while the written number of words stays about the same their distribution throughout the code changes significantly. Based on these results, we discuss the concrete advancements in newer Java versions. We also discuss to which extent new language advancements justify writing transformations in a general purpose language rather than a dedicated transformation language. We further indicate potential avenues for future research on the comparison of MTLs and GPLs in a model transformation context.
Organoids at the PUB : the porcine urinary bladder serves as a pancreatic niche for advanced cancer modeling
Creators: name: Melzer, Michael Karl
name: Breuning, Markus
name: Arnold, Frank
name: Wezel, Felix
name: Azoitei, Anca
name: Roger, Elodie
name: Krüger, Jana
name: Merkle, Jessica
name: Schütte, Lena
name: Resheq, Yazid
name: Hänle, Mark
name: Zehe, Viktor
name: Zengerling, Friedemann
name: Azoitei, Ninel
name: Klein, Lucas
name: Penz, Frederike
name: Singh, Shiv K.
name: Seufferlein, Thomas
name: Hohwieler, Meike
name: Bolenz, Christian
name: Günes, Cagatay
name: Gout, Johann
name: Kleger, Alexander
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: organ culture models
subject: pancreatic cancer
subject: stem cell differentiation
subject: DDC 610 / Medicine & health
subject: Pancreas; Cancer
subject: Pancreatic neoplasms
subject: Urinary bladder
subject: Pluripotent stem cells
subject: Cell differentiation
subject: Organ culture techniques
subject: Organoids
subject: Bauchspeicheldrüsenkrebs
subject: Induzierte pluripotente Stammzelle
subject: Zelldifferenzierung
subject: Organkultur
subject: Organoid

description: Despite intensive research and progress in personalized medicine, pancreatic ductal adenocarcinoma remains one of the deadliest cancer entities. Pancreatic duct-like organoids (PDLOs) derived from human pluripotent stem cells (PSCs) or pancreatic cancer patient-derived organoids (PDOs) provide unique tools to study early and late stage dysplasia and to foster personalized medicine. However, such advanced systems are neither rapidly nor easily accessible and require an in vivo niche to study tumor formation and interaction with the stroma. Here, the establishment of the porcine urinary bladder (PUB) is revealed as an advanced organ culture model for shaping an ex vivo pancreatic niche. This model allows pancreatic progenitor cells to enter the ductal and endocrine lineages, while PDLOs further mature into duct-like tissue. Accordingly, the PUB offers an ex vivo platform for earliest pancreatic dysplasia and cancer if PDLOs feature KRASG12D mutations. Finally, it is demonstrated that PDOs-on-PUB i) resemble primary pancreatic cancer, ii) preserve cancer subtypes, iii) enable the study of niche epithelial crosstalk by spiking in pancreatic stellate and immune cells into the grafts, and finally iv) allow drug testing. In summary, the PUB advances the existing pancreatic cancer models by adding feasibility, complexity, and customization at low cost and high flexibility.
Results of robotic liver surgery in association with IWATE criteria — the first 100 cases
Creators: name: Steinkraus, Kira Carlotta
name: Traub, Benno Konstantin
name: Heger, Patrick
name: Zaimi, Marin
name: Mihaljevic, André Leopold
name: Michalski, Christoph
name: Kornmann, Marko
name: Hüttner, Felix
Publisher: name: Universität Ulm
Year: 2024
Subjects: subject: Robotic liver surgery
subject: IWATE criteria
subject: Surgical site infections
subject: DDC 610 / Medicine & health

description: Background Aim of the current study was to present the results of the implementation phase of a robotic liver surgery program and to assess the validity of the IWATE difficulty score in predicting difficulty and postoperative complications in robotic liver surgery. Methods Based on the prospective database of the Interdisciplinary Robotic Center of Ulm University Hospital, the first 100 robotic liver surgeries were identified and analyzed. Perioperative parameters (duration of surgery and blood loss) and postoperative parameters including morbidity, mortality, and length of hospital stay were assessed and the results were compared between different IWATE difficulty categories. Results From November 2020 until January 2023, 100 robotic liver surgeries were performed (41 female, 59 male; median age 60.6 years, median BMI 25.9 kg/m2). Median duration of surgery was 180 min (IQR: 128.7), and median blood loss was 300 ml (IQR: 550). Ninety-day mortality was 2%, and overall morbidity was 21%, with major complications occurring in 13% of patients (≥ grade 3 according to Clavien/Dindo). A clinically relevant postoperative biliary leakage was observed in 3 patients. Posthepatectomy liver failure occurred in 7% (4 Grade A, 3 Grade B). Duration of surgery (p < 0.001), blood loss (p < 0.001), CCI (p = 0.004), overall morbidity (p = 0.004), and length of hospital stay (p < 0.001) were significantly increased in the IWATE ‘expert’ category compared to lower categories. Discussion Robotic surgery offers a minimally invasive approach for liver surgery with favorable clinical outcomes, even in the implementation phase. In the current study the IWATE difficulty score had the ability to predict both difficulty of surgery as well as postoperative outcomes when assessing the complexity of robotic liver surgery. Therefore, the role of the IWATE score in predicting these outcomes highlights its importance as a tool in surgical planning and decision-making.
Depression and quality of life in old age: a closer look
Creators: name: Hussenoeder, Felix S.
name: Jentzsch, Doreen
name: Matschinger, Herbert
name: Hinz, Andreas
name: Kilian, Reinhold
name: Riedel-Heller, Steffi G.
name: Conrad, Ines
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Depression
subject: Quality of life
subject: WHOQOL-BREF
subject: WHOQOL-OLD
subject: Older age
subject: DDC 610 / Medicine & health

description: Abstract Depressive disorders are among the most widespread mental disorders in old age, with negative consequences for quality of life (QOL). Understanding QOL as a multidimensional construct, in this article we have a closer look on what specific aspects are affected by depression. We used a representative sample of the German population (n = 805) and one of individuals diagnosed with depression (n = 106) to compare QOL using the WHOQOL-BREF and the WHOQOL-OLD. Multivariate analysis showed that individuals diagnosed with depression exhibited lower QOL with regard to WHOQOL-BREF-dimensions physical health, psychological, social relationships and global QOL and with regard to WHOQOL-OLD-facets sensory abilities, past, present, and future activities and social participation. In addition, in the regression analysis, there were no significant differences between individuals with and without depression with regard to environment (WHOQOL-BREF), autonomy, death and dying, intimacy and overall (WHOQOL-OLD). Associations between depression and QOL in older age are selective in terms of which aspects of QOL are affected. From a methodological perspective, a multidimensional approach to QOL is recommended. From a clinical perspective, our research highlights those areas of QOL that are relevant for health professionals working with older people and that could be the focus of interventions.
Supplementary Figure 3. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Stimulated Rop7 T cells were incubated together with a mixture of Rop7-peptide-loaded and DMSO-treated WT splenocytes. The histograms show the ratio of live Rop7 peptide-loaded splenocytes to live control splenocytes after incubation with indicated ratio of activated Rop7 CD8 T cells. Error bars: standard deviation of 3 technical replicates. Representative of 2 independent experiments.
"The Castles", Downhall, Aikton.
Creators: name: Bennett, Julian
name: Herne, A
name: Whitworth, A
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 67-82
description: Reports trial trenching of a moated site (one of two within one parish); adds a checklist of Cumberland moats.
Fe based core–shell model catalysts for the reaction of CO2 with H2
Creators: name: Kirchner, Johann
name: Zambrzycki, Christian
name: Baysal, Zeynep
name: Güttel, Robert
name: Kureti, Sven
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Core–shell
subject: CO2 hydrogenation
subject: Particle size
subject: Structure–activity correlation
subject: DDC 540 / Chemistry & allied sciences
subject: Catalysts
subject: Iron
subject: Particles
subject: Auslöser
subject: Kern-Schale-Struktur
subject: Eisen
subject: Teilchengröße

description: Abstract Fe@SiO2 core–shell model catalysts were investigated for the conversion of CO2 and H2 into CH4, CO and H2O. For evaluation of the effect of core size on the catalytic activity, samples with Fe particle sizes of 4, 6 and 8 nm were prepared. Fresh and spent catalysts were thoroughly characterized by X-ray diffraction, 57Fe Mössbauer spectroscopy, transmission electron microscopy, temperature programmed hydrogenation and X-ray photoelectron spectroscopy. As a result, the yield of the major product CO as well as CH4 was increased with Fe core size. Additionally, growing Fe cores led to stronger carburization and higher amount of reactive carbide entities, which drive the CH4 formation. Finally, formation of inactive bulk carbon deposition is strongly suppressed for the core–shell catalysts in comparison to bulk iron oxide catalysts used for CO2 hydrogenation.
The Roman garrisons of Maryport.
Creators: name: Jarrett, Michael G
name: Stephens, G R
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 61-66
description: A new timetable is offered for garrisons from AD 122 to 3rd century.
Macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with activity against SARS-CoV-2
Creators: name: Groß, Rüdiger Martin
name: Dias Loiola, Livia Mesquita
name: Issmail, Laila
name: Uhlig, Nadja
name: Eberlein, Valentina
name: Conzelmann, Carina
name: Olari, Ria-Raluca
name: Rauch, Lena
name: Lawrenz, Jan
name: Weil, Tatjana
name: Müller, Janis-Alexander
name: Borba Cardoso, Mateus
name: Gilg, Andrea
name: Larsson, Olivia
name: Höglund, Urban
name: Axberg Pålsson, Sandra
name: Selch Tvilum, Anna
name: Borup Løvschall, Kaja
name: Kristensen, Maria M.
name: Spetz, Anna-Lena
name: Hontonnou, Fortune
name: Galloux, Marie
name: Grunwald, Thomas
name: Zekilin, Alexander N.
name: Münch, Jan
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Broad-spectrum antivirals
subject: Entry inhibitors
subject: In vivo
subject: Macromolecules
subject: Polyanions
subject: Respiratory syncytial virus (RSV)
subject: DDC 610 / Medicine & health
subject: Viral fusion protein inhibitors
subject: Respiratory syncytial virus
subject: SARS-CoV-2
subject: Viruzid
subject: RS-Virus
subject: SARS-CoV-2
subject: Polyanion
subject: Makromolekül

description: Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
Supplementary Figure 4. from Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions
Creators: name: Swee, Lee Kim
name: Tan, Zhen Wei
name: Sanecka, Anna
name: Yoshida, Nagisa
name: Harshil Patel
name: Grotenbreg, Gijsbert
name: Eva-Maria Frickel
name: Ploegh, Hidde L.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Row centered heatmap of TPM values in unstimulated Rop7-I, -II and -III CD8 T cells (R7-I, R7-II and R7-III) showing genes associated with the Ingenuity Pathway cell cycle progression depicted in Figure 8B and found to be significantly differentially expressed (FDR≥1) in the comparison between Rop7-I and Rop7-III CD8 T cells.
Cell composition at the vitreomacular interface in traumatic macular holes
Creators: name: Guenther, Stefanie R.
name: Schumann, Ricarda G.
name: Zaytseva, Yulia
name: Hagenau, Felix
name: Wolf, Armin
name: Priglinger, Siegfried G.
name: Vogt, Denise
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Traumatic macular hole
subject: Internal limiting membrane
subject: Membrane peeling
subject: Vitreomacular interface
subject: Immunocytochemistry
subject: Transmission electron microscopy
subject: DDC 610 / Medicine & health

description: Abstract Purpose To describe characteristics of the vitreomacular interface (VMI) in traumatic macular holes (TMH) compared to idiopathic macular holes (IMH) using immunofluorescence and electron microscopy, and to correlate with clinical data. Methods For immunocytochemical and ultrastructural analyses, premacular tissue with internal limiting membrane (ILM) and epiretinal membrane (ERM) was harvested during vitrectomy from 5 eyes with TMH and 5 eyes with IMH. All specimens were processed as flat mounts for phase-contrast microscopy, interference and fluorescence microscopy, and transmission electron microscopy (TEM). Primary antibodies were used against microglial and macroglial cells. Clinical data was retrospectively evaluated. Results Surgically excised premacular tissue of eyes with TMH showed a less pronounced positive immunoreactivity for anti-glutamine synthetase, anti-vimentin and anti-IBA1 compared to eyes with IMH. Cell nuclei staining of the flat-mounted specimens as well as TEM presented a lower cell count in eyes with TMH compared to IMH. All detected cells were found on the vitreal side of the ILM. No collagen fibrils were seen in specimens of TMH. According to patients’ age, intraoperative data as well as spectral-domain optical coherence tomography (SD-OCT) analysis revealed an attached posterior vitreous in the majority of TMH cases (60%), whereas all eyes with IMH presented posterior vitreous detachment. Conclusion The vitreomacular interface in TMH and IMH shows significant differences. In TMH, glial cells are a rare finding on the vitreal side of the ILM.
A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation
Creators: name: Tschaffon, Miriam E. A.
name: Reber, Stefan O.
name: Schoppa, Astrid
name: Nandi, Sayantan
name: Cirstea, Ion C.
name: Aszodi, Attila
name: Ignatius, Anita
name: Haffner-Luntzer, Melanie
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Transdifferentiation
subject: Cartilage to bone transformation
subject: Endochondral ossification
subject: Chondrocyte
subject: In vitro assay
subject: DDC 610 / Medicine & health
subject: Osteogenesis
subject: Chondrocytes
subject: Fracture healing
subject: Knochenbildung
subject: Knorpelzelle
subject: Frakturheilung

description: Purpose Endochondral ossification, which involves transdifferentiation of chondrocytes into osteoblasts, is an important process involved in the development and postnatal growth of most vertebrate bones as well as in bone fracture healing. To study the basic molecular mechanisms of this process, a robust and easy-to-use in vitro model is desirable. Therefore, we aimed to develop a standardized in vitro assay for the transdifferentiation of chondrogenic cells towards the osteogenic lineage. Methods Murine chondrogenic ATDC5 cells were differentiated into the chondrogenic lineage for seven days and subsequently differentiated towards the osteogenic direction. Gene expression analysis of pluripotency, as well as chondrogenic and osteogenic markers, cell–matrix staining, and immunofluorescent staining, were performed to assess the differentiation. In addition, the effects of Wnt3a and lipopolysaccharides (LPS) on the transdifferentiation were tested by their addition to the osteogenic differentiation medium. Results Following osteogenic differentiation, chondrogenically pe-differentiated cells displayed the expression of pluripotency and osteogenic marker genes as well as alkaline phosphatase activity and a mineralized matrix. Co-expression of Col2a1 and Col1a1 after one day of osteogenic differentiation indicated that osteogenic cells had differentiated from chondrogenic cells. Wnt3a increased and LPS decreased transdifferentiation towards the osteogenic lineage. Conclusion We successfully established a rapid, standardized in vitro assay for the transdifferentiation of chondrogenic cells into osteogenic cells, which is suitable for testing the effects of different compounds on this cellular process.
title: OFROM: interview avec unine15a30d
Creators: name: Delafontaine, François
name: Hiroz, Nathaniel
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.bb319t6o.v2#99309439969a43258eed716deb5e3d9dc20aef61
Development of enhanced three-dimensional printed packings for scale-up of distillation columns : a successful case study
Creators: name: Neukäufer, Johannes
name: Ashour, Mohamed Adel
name: Sarajlic, Nadin
name: Klein, Harald
name: Rehfeldt, Sebastian
name: Hallmann, Heiko
name: Meinicke, Sebastian
name: Paschold, Jürgen
name: Knösche, Carsten
name: Grützner, Thomas
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: 3D printing
subject: miniaturization
subject: scale-up
subject: structured packing
subject: DDC 540 / Chemistry & allied sciences
subject: Three-dimensional printing
subject: Distillation
subject: 3D-Druck
subject: Destillation
subject: Miniaturisierung
subject: Maßstabübertragung

description: This publication presents a general approach for the enhancement of packings regarding scalability, separation efficiency, and fluid dynamic properties using three-dimensional (3D) printing. The methodology is used to develop miniaturized, scalable packings for process development, and scale-up applications. For this purpose, a 3D printable computer-aided design version of the Rombopak 9M industrial packing (RP9M-3D), which is known for its positive scalability properties, was created. An initial characterization by means of computational fluid dynamics simulations and mass transfer measurements reveals positive but also negative design properties. These findings are used to create a more advanced, miniaturized packing structure, the XW-Pak. The evolved structure is compared to the RP9M-3D. The simulation and experimental results show that the enhanced packing, which is still in the early stages of development, exhibits higher separation efficiencies with improved scalability properties at the same void fraction and surface area than the RP9M-3D.
Development of a risk-informed and performance-based safety case for TerraPower’s Molten Chloride Reactor Experiment (MCRE)
Creators: name: Chisholm, Brandon M.
Publisher: name: F1000 Research Limited
Year: 2024

description: This presentation was given as part of the American Nuclear Society Risk-informed, Performance-based Policy and Procedures Committee (RP3C) Community of Practice (CoP). For more information on the RP3C CoP, please visit https://www.ans.org/standards/rp3c/cop/.



This presentation took place on January 26, 2024.



The presentation video recording can be found online at https://youtu.be/Ufp05puA7dQ.
G. Julius Marcus.
Creators: name: Stephens, G R
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 53-60
description: Discussion of a milestone inscription at Welton, near Milecastle 17, and its wider implications for garrisons and rebuilding activities; also a note on the Jarrow war memorial (RIB 1051a, b).
A Roman Bridge Stone from the River Eden, Carlisle.
Creators: name: Caruana, Ian D
name: Coulston, Jon C N
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 43-52
description: D Charlesworth's photograph of a stone (bearing the small relief sculpture of a ?river-god's head) is identified as from the Eden near Stanwix. The putative Roman bridge position is discussed in relation to the road network and forts, perhaps also a long causeway.