cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Über die Verbreitung des Frühsommer-Meningoenzephalitis (FSME)-Virus und der Zeckenparalyse in Mecklenburg-Vorpommern
Tick-borne encephalitis (TBE) virus and tick paralysis in Mecklenburg-Western Pomerania
Creators: name: Frimmel, Silvius
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 500 Natural sciences
subject: 610 Medical sciences Medicine

description: Die Arbeit beschreibt das Vorkommen der Frühsommer-Meningoenzephalitis (FSME) und die seltene Differentialdiagnose, die Zeckenparalyse, in Mecklenburg-Vorpommern (M.-V.). Durch Untersuchung von humanen autochthonen Fällen, von Zecken auf FSMEV-RNA, sowie von Seren von Wild- und Nutztieren aus M.-V. auf FSMEV-Antikörper, konnten Gebiete mit einem möglichen Risiko der FSME-Übertragung identifiziert werden. Es wurde gezeigt, dass FSME-Naturherde über Jahrzehnte aktiv bleiben können, und dass auch in Nicht-Risikogebieten die FSME als Differentialdiagnose von Enzephalitiden zu berücksichtigen ist.
Relationships between ligand binding sites, protein architecture and correlated paths of energy and conformational fluctuations
Creators: name: Erman, Burak
Publisher: name: arXiv
Year: 2011
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Statistical thermodynamics basis of energy and residue position fluctuations is explained for native proteins. The protein and its surroundings are treated as a canonical system with emphasis on the effects of energy exchange between the two. Fluctuations of the energy are related to fluctuations of residue positions, which in turn are related to the connectivity matrix of the protein, thus establishing a connection between energy fluctuation pathways and protein architecture. The model gives the locations of hotspots for ligand binding, and identifies the pathways of energy conduction within the protein. Results are discussed in terms of two sets of models, the BPTI and twelve proteins that contain the PDZ domain. Possible use of the model for determining functionally similar domains in a diverse set of proteins is pointed out.
description: 25 pages, 6 figures
Are causes ever too strong?
Creators: name: McHugh, D.M.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Humanities
subject: FOS: Humanities
subject: 20 Language, Communication and Culture

description: Is the truth of a causal claim always preserved by strength- ening the cause? For instance, does “Alice flicking the switch caused the light to turn on” entail “Alice flicking the switch and it raining in New Zealand caused the light to turn on”? We argue for this entailment, proposing that causal claims are downward monotone in their cause: if C+ entails C then (C caused E) entails (C+ caused E). In other words, causes are never too strong. We argue for this by presenting examples of causal claims that are assertable even though the cause is stronger than required for the claim to be true (Sect. 2). These data challenge accounts (the most prominent of which is Halpern, Actual Causality 2016) that predict such sentences to be false. Instead, we trace differences in their acceptability to their scalar implicatures (Sect. 3). Finally, we show that Halpern’s semantics of causal claims can be easily adapted to account for the data we consider; namely, by dropping his ‘minimality’ condition (Sect. 4).
The targum (1880:Nov. 8 - 1880:Nov. 26)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1880

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Entwicklung von realitätsnahen Prüfprozeduren für Durchflussmessgeräte basierend auf realen Verbrauchsprofilen
Creators: name: Schumann, Daniel
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 500 Natural sciences
subject: 620 Engineering & allied operations
subject: 624 Structural and Environmental Engineering

description: Der innerhalb der Arbeit entwickelte Algorithmus ermöglicht es, basierend auf empirisch ermittelten Wasserverbräuchen, statistisch gesicherte Flussratensequenzen zu erzeugen, welche zur realitätsnäheren Prüfung von Flüssigkeitsmessgeräten eingesetzt werden können.
Sins between the pages : the pornographic book trade in London, 1870-1900
Creators: name: O'Hearn, Justin
Publisher: name: University of British Columbia
Year: 2018

description: This dissertation examines the trade in pornographic texts in London during the late Victorian period. It argues that not only are these texts underrepresented in scholarship, but also that they provide vital historical documentation on the evolution of sexual thought and were among the first to acknowledge the link between sexuality and identity. This dissertation establishes a narrative of the publishers, writers, and consumers involved in the pornographic book trade and their material connection to the study and history of sexuality; the basis of this history is extensive archival work and research informed as much by what information was available in archives and, sometimes more importantly, by what was missing. In detailing the history of pornographic books and how the trade functioned in the metropolis of London—and Britain more generally—this dissertation focuses on a new intellectual movement, closely aligned to sexology but without medical pretense, that prefigured contemporary understandings of sexuality. Certain publishers took greater risks with the material they published in response to expanding readerships that created a world of fantasy that was increasingly introspective. This dissertation argues that late Victorian pornographic books reflected and, in some cases, magnified the interior sexual lives of readers. The content of the pornographic texts in this study progressively presented readers with sexualities that were increasingly connected with self-identity rather than simply series of acts. Collector cultures grew alongside this evolution in pornographic books and, as a result, created niche markets for books as aesthetic objects as well as for their specialized content. This dissertation makes new and original critical interventions in important areas of book history and print culture studies. The examination of the pornographic book trade during that latter part of the nineteenth century argues that exploitation and adaptation or earlier literary sex book traditions resulted in new presentations and understandings of the impact clandestine books could have on sex. This dissertation is the first significant scholarship on the 1899 novel Des Grieux and also the first to positively identify publisher William Lazenby.
Ermittlung von Struktur-Reaktivitätsbeziehungen in CeO2-basierten Katalysatoren für die Selektive Katalytische Tieftemperatur-NH3-Reduktion von NOx
Creators: name: Keller, Sonja
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 540 Chemistry & allied sciences

description: Die vorliegende Dissertation beschäftigt sich mit dem Einfluss von dreiwertigen Dotierungselementen auf die katalytische Aktivität von Ceroxiden in der NH3-SCR von NOx mit und ohne V-Imprägnierung. Als Dotierungselemente wurden Fe3+, Y3+, Co3+, Sb3+ und Bi3+ in unterschiedlicher Konzentration gewählt. Die so entstandenen Mischoxide und festen Lösungen des Typs Ce(1-x)MxO(2-d) wurden katalytischer Testung unterworfen und umfangreich charakterisiert. Um die Struktur der Katalysatoren unter Reaktionsbedingungen zu verstehen, wurden operando DRIFTS, EPR und in situ XANES angewandt.
Additional file 2 of Genetic characterization of Addison’s disease in Bearded Collies
Creators: name: Gershony, Liza C.
name: Belanger, Janelle M.
name: Hytönen, Marjo K.
name: Lohi, Hannes
name: Famula, Thomas R.
name: Oberbauer, Anita M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table 1. Genotypes of the Bearded Collies analyzed at the four SNPs of interest. Genotypes of the 140 Bearded Collies (55 AD cases, 85 healthy controls) analyzed at each of the four SNPs of interest: BICF2G630307993 on canine chromosome (CFA) 11, BICF2G630109748 on CFA16, BICF2P1230367 on CFA18 and BICF2P977298 on CFA29.
Salt River Basin
Creators: name: Carey, Daniel I.
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2009

description: Abstract:
The Salt River Basin and adjacent Ohio River drainages include over 4,150 square miles in all or parts of 19 counties. The basin contains more than 9,600 miles of streams.
Over 660 miles of streams assessed in the basin by the Kentucky Division of Water do not support designated uses for warm-water aquatic habitat, fish consumption, or primary contact recreation (swimming). Not all streams have been assessed. The percentage of assessed streams not supporting uses was: warm-water aquatic habitat (38 percent); fish consumption (36 percent); primary contact recreation (86 percent). Over 100 miles of streams have been declared special use waters: either exceptional waters or reference reach waters. For more infomtation on the assessment process and stream ratings, go to www.water.ky.gov/sw/swmonitor/.305b/.
There are five remediation priority watersheds, including over 600 square miles: primary impacts are pathogens, nutrients, low dissolved oxygen, siltation, and habitat alteration caused by industrial and municipal wastewater discharges, urban runoff, agriculture, habitat modification, and failed septic systems.
There are six man-made lakes in the basin, ranging in size from the 50 acre McNeely Lake to Taylorsville Lake, which provides nearly 3,000 acres for recreation. There are nearly 60,000 acres of wetlands in the basin.
On the demography of Echinochloa crus-galli and the effect of post-dispersal seed predation in maize fields
Creators: name: Pannwitt, Heike
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 630 Agriculture

description: The goal of this study was to identify the demography of the weed Echinochloa crus-galli and the effect of post-dispersal seed predation in maize fields. In the presence of seed predators, the number of seedlings was reduced, but density-dependent processes during seedling emergence, seedling survival, and fecundity per capita compensated the losses. In summary, to control weeds, seed predation needs to be combined with other control measures that target the seedling survival and fecundity.
Additional file 3 of Genetic characterization of Addison’s disease in Bearded Collies
Creators: name: Gershony, Liza C.
name: Belanger, Janelle M.
name: Hytönen, Marjo K.
name: Lohi, Hannes
name: Famula, Thomas R.
name: Oberbauer, Anita M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Table 2. Model assessment. Values for the leave-one-out information criterion (looic) and standard error associated with each of the predictive SNP models tested. The model with the smallest looic value is considered the best, most parsimonious, fit.
Collisional Grooming Models of the Kuiper Belt Dust Cloud
Creators: name: Kuchner, Marc J.
name: Stark, Christopher C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We modeled the 3-D structure of the Kuiper Belt dust cloud at four different dust production rates, incorporating both planet-dust interactions and grain-grain collisions using the collisional grooming algorithm. Simulated images of a model with a face-on optical depth of ~10^-4 primarily show an azimuthally-symmetric ring at 40-47 AU in submillimeter and infrared wavelengths; this ring is associated with the cold classical Kuiper Belt. For models with lower optical depths (10^-6 and 10^-7), synthetic infrared images show that the ring widens and a gap opens in the ring at the location of of Neptune; this feature is caused by trapping of dust grains in Neptune's mean motion resonances. At low optical depths, a secondary ring also appears associated with the hole cleared in the center of the disk by Saturn. Our simulations, which incorporate 25 different grain sizes, illustrate that grain-grain collisions are important in sculpting today's Kuiper Belt dust, and probably other aspects of the Solar System dust complex; collisions erase all signs of azimuthal asymmetry from the submillimeter image of the disk at every dust level we considered. The model images switch from being dominated by resonantly-trapped small grains ("transport dominated") to being dominated by the birth ring ("collision dominated") when the optical depth reaches a critical value of tau ~ v/c, where v is the local Keplerian speed.
description: 31 pages, including 9 figures
Aboutness and Modality
Creators: name: McHugh, D.M.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: subject: Humanities
subject: FOS: Humanities
subject: Information and Computing Sciences
subject: 20 Language, Communication and Culture
subject: Mathematics
subject: FOS: Mathematics

description: In this paper I would like to offer a new framework for hypothetical reasoning, with the goal of predicting what scenarios we consider when we interpret a conditional or causal claim (such as a sentence containing the word because). The idea is that when we interpret a conditional or causal claim, we identify a part of the world to change and imagine changing that. Sentences are about parts of the world: when we interpret a conditional antecedent or because clause, we allow the part of the world it is about to vary. This expands our modal horizons, which we restrict to those scenarios where the sentence we are asked to imagine true is indeed true. To evaluate a whole conditional or causal claim we look to the possible futures after this change. My main evidence for this approach is that it gives just the right range of hypothetical scenarios to account for how we interpret both conditionals and causal claims. Some approaches (such as Stalnaker and Lewis’s semantics of conditionals based on similarity, and Kratzer’s premise semantics) consider too few scenarios, while others (such as Fine’s 2012 truthmaker semantics of conditionals) consider too many. The present approach inhabits a Goldilocks zone between these extremes: not too restrictive, not too permissive, but just right.
GaAs/AlGaAs quantum wire lasers fabricated by cleaved edge overgrowth
Creators: name: Wegscheider, Werner
name: Pfeiffer, Loren N.
name: West, Kenneth W.
name: Pinczuk, A.
name: Dignam, M. M.
name: Hull, R.
name: Leibenguth, R. E.
Publisher: name: Universität Regensburg
Year: 1995
Subjects: subject: 530 Physik

description: We have used the molecular beam growth technique which we call “cleaved edge overgrowth” to fabricate quantum wire lasers, in which 1D quantum confinement is entirely defined by the growth process. The active region of our lasers consists of atomically precise quantum wires that form at the T-shaped intersections of 7 nm wide GaAs quantum wells grown along the [001] crystal axis and after an in situ cleave along the [110] crystal axis. The origin of the quantum mechanical bound state is the relaxation of quantum well confinement at this intersection. The high degree of structural perfection achievable in this way allows the observation of stimulated optical emission from the lowest exciton state in optically as well as in electrically pumped devices. The formation of a linear p-n junction in which the quantum wires are embedded is achieved by doping with Be and Si in the two orthogonal growth directions. Efficient current injection into the wires is demonstrated by the almost complete suppression of optical emission from the quantum well states as well as by threshold currents as low as 0.4 mA for uncoated devices at 1.7 K.
Rhegmatogene Amotio retinae
Creators: name: Braunschweig, Marie
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 500 Natural sciences
subject: 610 Medical sciences Medicine

description: Die rhegmatogene Amotio retinae ist ein komplexes Krankheitsbild und ein Notfall in der Augenheilkunde. Die Therapie mittels Vitrektomie hat in den letzten Jahren zunehmend an Bedeutung gewonnen. Diese retrospektive Studie stellt den langfristigen Therapieerfolg nach der operativen Versorgung der rhegmatogenen Amotio retinae durch die Pars plana Vitrektomie im Zeitraum 2008 bis 2012 dar. Es wurden die postoperative Sehstärke und Wiederanlagerate der Retina zum Ende des Nachbeobachtungszeitraums untersucht und prä-, intra- und postoperative Einflussfaktoren dargestellt.
An air shower array for LOFAR: LORA
Creators: name: Thoudam, S.
name: Aar, G. v.
name: Akker, M. v. d.
name: Bähren, L.
name: Corstanje, A.
name: Falcke, H.
name: Hörandel, J. R.
name: Horneffer, A.
name: James, C.
name: Mevius, M.
name: Scholten, O.
name: Singh, K.
name: ter Veen, S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: LOFAR is a new form of radio telescope which can detect radio emission from air showers induced by very high-energy cosmic rays. It can also look for radio emission from particle cascades on the Moon induced by ultra high-energy cosmic rays or neutrinos. To complement the radio detection, we are setting up a small particle detector array LORA (LOfar Radboud Air shower array) within an area of $\sim 300$ m diameter in the LOFAR core. It will help in triggering and confirming the radio detection of air showers with the LOFAR antennas. In this paper, we present a short overview about LORA and discuss its current status.
description: 10 pages (using article.cls), 6 figures, accepted for the proceedings of 22nd European Cosmic Ray Symposium, 3-6 August 2010, Finland
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3
Creators: name: de Iturrate, Paula Martínez
name: Sebastián-Pérez, Victor
name: Nácher-Vázquez, Montserrat
name: Tremper, Catherine S.
name: Smirlis, Despina
name: Martín, Julio
name: Martínez, Ana
name: Campillo, Nuria E.
name: Rivas, Luis
name: Gil, Carmen
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β inhibitors, as well as from the Leishbox collection of leishmanicidal compounds developed by GlaxoSmithKline. As a result, new leishmanicidal inhibitors acting on Leishmania GSK-3 at micromolar concentrations were found. These inhibitors belong to six different chemical classes (thiadiazolidindione, halomethylketone, maleimide, benzoimidazole, N-phenylpyrimidine-2-amine and oxadiazole). In addition, the binding mode of the most active compounds into Leishmania GSK-3 was approached using computational tools. On the whole, we have uncovered new chemical scaffolds with an appealing prospective in the development and use of Leishmania GSK-3 inhibitors against this infectious protozoan.
Additional file 2 of Understanding personalized dynamics to inform precision medicine: a dynamic time warp analysis of 255 depressed inpatients
Creators: name: K. Hebbrecht
name: M. Stuivenga
name: T. Birkenhäger
name: M. Morrens
name: E. I. Fried
name: B. Sabbe
name: E. J. Giltay
Publisher: name: figshare
Year: 2020
Subjects: subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Figure S1. Network plots based on the DTW analyses in the 255 patients. We compared the network structure based on all data from all patients, and the analyses based only on symptoms that did not score as 0 throughout the follow-up. Such symptom pairs with scores of 0 will result in a distance of 0, solely because they were absent in some patients. Figure S2. Average DTW distance according to response and remission, including symptoms that scored zero throughout the hospitalization. Figure S3. Network plots based on the DTW analyses in 231 of the 255 patients, who had a clinical diagnosis of either MDD of BD. We compared the network structure [A and B] and calculated the mean distance only on symptoms that did not score as 0 throughout the follow-up. Although the network structure was largely similar, on average patients with BD had a denser distance matric than patients with MDD (P=0.0028). Figure S4. Network plots of two subsamples [A and B] of the 255 patients. We used an automated split with a subset of 128 and 127 patients, in which we conducted separate DTW analyses. Node placement was done by using the Procrustes algorithm (from the R Package ‘networktools’), to aid the visual comparison between the two networks. As a result, configurations were brought into a similar space in which statistically meaningless differences were removed without changing the fit. This analysis showed that the network (based on each of the average distance matrixes were stable. The congruence coefficient was high at 0.994, when we compared both sets of compromise factors derived from each Distatis analysis.
МАССОВЫЙ ЧЕЛОВЕК И ЕГО РЕЧЕВЫЕ АМПЛУА ПРОСТАКА, БАЛАГУРА, МЕНТОРА В РУССКОЙ ПРОЗЕ 1920-Х ГОДОВ
Creators: name: Шевченко, Екатерина
Publisher: name: ООО Цифра
Year: 2023
Subjects: mass man
subject of speech
speech role
tale
buffoonery
mentor tone
aggressive ignorance
reduction of the personal
trickery
hypocrisy
rumour
scandal situation
массовый человек
субъект речи
речевое амплуа
сказ
балагурство
менторский тон
агрессивное невежество
редукция личностного
плутовство
лицедейство
молва
ситуация скандала

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation
Creators: name: Elie, Jonathan
name: Feizbakhsh, Omid
name: Desban, Nathalie
name: Josselin, Béatrice
name: Baratte, Blandine
name: Bescond, Amandine
name: Duez, Julien
name: Fant, Xavier
name: Bach, Stéphane
name: Marie, Dominique
name: Place, Matthieu
name: Salah, Sami Ben
name: Chartier, Agnes
name: Berteina-Raboin, Sabine
name: Chaikuad, Apirat
name: Knapp, Stefan
name: Carles, Fabrice
name: Bonnet, Pascal
name: Buron, Frédéric
name: Routier, Sylvain
name: Ruchaud, Sandrine
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relationship was established. An assessment of the inhibitory activity of the lead structures on human Haspin and several other protein kinases is presented. The lead structure was rapidly optimised using a combination of crystal structures and effective docking models, with the best inhibitors exhibiting potent inhibitory activity on Haspin with IC50 between 6 and 100 nM in vitro. The developed inhibitors displayed anti-proliferative properties against various human cancer cell lines in 2D and spheroid cultures and significantly inhibited the migration ability of osteosarcoma U-2 OS cells. Notably, we show that our lead compounds are powerful Haspin inhibitors in human cells, and did not block G2/M cell cycle transition due to improved selectivity against CDK1/CyclinB.
Untersuchung des Atemgasmetaboloms bei pädiatrischen Patienten mittels Echtzeit-Massenspektrometrie
Creators: name: Happ, Josephine
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die Untersuchung der Atemluft mittels adaptierter Echtzeit-Massenspektrometrie ermöglicht eine schnelle Charakterisierung des Atemgasmetaboloms pädiatrischer Patienten für punktuelle Messungen und im zeitlichen Verlauf. VOC-Exhalationsprofile von Kindern und Jugendlichen mit Diabetes mellitus Typ 1 und von gesunden Kindern und Jugendlichen weisen zahlreiche unterschiedliche Atemgasmarkerkonzentrationen auf, wodurch Erkenntnisse über pathologische Prozesse im Organismus der pädiatrischen Patienten mit Diabetes mellitus Typ 1 gewonnen werden können.
Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents
Creators: name: Veschi, Serena
name: Carradori, Simone
name: De Lellis, Laura
name: Florio, Rosalba
name: Brocco, Davide
name: Secci, Daniela
name: Guglielmi, Paolo
name: Spano, Mattia
name: Sobolev, Anatoly P.
name: Cama, Alessandro
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial agent, we explored a large library of newly synthesised derivatives to unravel the importance of the OH moiety and pyridine ring of the parent compound. The new derivatives showed a valuable anti-proliferative effect and some displayed a greater effect as compared to nitroxoline against three pancreatic cancer cell lines with different genetic profiles. In particular, in silico pharmacokinetic data, clonogenicity assays and selectivity indexes of the most promising compounds showed several advantages for such derivatives, as compared to nitroxoline. Moreover, some of these novel compounds had stronger effects on cell viability and/or clonogenic capacity in PC cells as compared to erlotinib, a targeted agent approved for PC treatment.
Klinisches und funktionelles Outcome nach primärer Knieendoprothesenimplantation in Abhängigkeit von der Patellaführung
Creators: name: Dahlmann, Sebastian Alexander
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 610 Medical sciences Medicine

description: Retrospektive Studie zur Evaluation des Einflusses eines Patellamaltrackings auf das klinische und funktionelle Outcome nach primärer Knieprothesenimplantation in einem Follow-up-Zeitraum von 60 Monaten mittels Auswertung mehrerer röntgenbasierter Indizes und krankheitsspezifischer und -unspezifischer klinischer Scores. Es wurden zwei Faktoren identifiziert, die einen signifikanten Einfluss auf das postoperative Ergebnis haben: ein erhöhter patellarer Tilt > 4° und ein reduzierter patellarer Facettenwinkel < 142°. Zudem wurden neue Methoden zur Messung des Patella-Shifts und -Tilt eingeführt.
A precise response function for the magnetic component of Gravitational Waves in Scalar-Tensor Gravity
Creators: name: Corda, Christian
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The important issue of the magnetic component of gravitational waves (GWs) has been considered in various papers in the literature. From such analyses, it resulted that such a magnetic component becomes particularly important in the high frequency portion of the frequency range of ground based interferometers for GWs which arises from standard General Theory of Relativity (GTR). Recently, such a magnetic component has been extended to GWs arising from Scalar-Tensor Gravity (STG) too. After a review of some important issues on GWs in STG, in this paper we re-analyse the magnetic component in the framework of STG from a different point of view, by correcting an error in a previous paper and by releasing a more precise response function. In this way, we also show that if one neglects the magnetic contribution considering only the low-frequency approximation of the electric contribution, an important part of the signal could be, in principle, lost. The determination of a more precise response function for the magnetic contribution is important also in the framework of the possibility to distinguish other gravitational theories from GTR. At the end of the paper an expansion of the main results is also shown in order to recall the presence of the magnetic component in GRT too.
description: Accepted for publication in Physical Review D, to be published during 2011. 36 pages, in this second version typos have been corrected and references have been updated
Die Auswirkungen hypoxisch präkonditionierter muriner mesenchymaler Stammzellen auf postinfarzielle Arrhythmien im Mausmodell
Creators: name: Ahmad, Beschan
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Zusammenfassend verringerte die intramyokardiale Injektion der MSCs in einem Doppelinfarkt Maus-Maus-Modell das Auftreten einfacher und komplexerer Arrhythmien. Dieser Effekt ist im Zusammenhang mehrerer Mechanismen zu sehen und wurde in dieser Studie anhand der Infarktgröße bestätigt.
Exhaustification in the semantics of ‘cause’ and ‘because’
Creators: name: McHugh, D.M.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: 20 Language, Communication and Culture
subject: Information and Computing Sciences
subject: Humanities
subject: FOS: Humanities

description: We show that a single operation can account for three seemingly distinct properties of the semantics of cause and because. The properties are, firstly, their comparative nature: interpreting cause and because involves comparing what would happen in the presence of the cause (a positive condition) with what would happen in the absence of the cause (a negative condition). Secondly, there is an asymmetry in logical strength between the two conditions: the positive condition involves a universal modal while the negative condition involves an existential modal. Thirdly, the positive and negative conditions have the same modal base, i.e. are interpreted while assuming the same set of background facts. Despite their apparent dissimilarity, we show that these three properties are predicted by a single operation: exhaustification. The comparative nature of cause and because follows from the comparative nature of exhausatification, which compares a sentence with its alternatives. The asymmetry in strength arises because exhaustification negates alternatives: given the duality between universal and existential quantification, negation flips a necessity modal into a possibility modal, producing the observed strength asymmetry. Finally, the positive and negative condition have the same modal base since, rather cause and because having two modals in their semantics—one for the positive condition and one for the negative condition—their semantics contains a single modal which is copied by exhaustification. We conclude by showing that this exhaustification operator violates Economy constraints, suggesting that it is not subject to licensing conditions but part of lexical semantics of cause and because.
Charakterisierung und Modellierung des dynamischen Betriebs eines Schiffsdieselmotors hinsichtlich Kraftstoffverbrauch und Emissionen
Creators: name: Dahms, Felix
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 620 Engineering & allied operations

description: Thematisiert wird der dynamische Betrieb von Schiffsmotoren, der mit einem Mehrverbrauch und erhöhten Emissionen verbunden ist. Reale Anwendungsbeispiele im maritimen Sektor sind Schiffsmanöver mit ihren wechselnden Bewegungszuständen und Maschinenkommandos. Dieser fluktuierende Energiebedarf der Vortriebs- und Steuerorgane bestimmt die Betriebsprofile der energiebereitstellenden Hauptmaschinen. Die vorgestellten Methoden analysieren die Hintergründe und identifizieren Optimierungspotentiale zur Brennstoffeinsparung und Emissionsreduktion sowohl für bestehende als auch zukünftige Systeme.
Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors
Creators: name: Im, Daseul
name: Moon, Hyungwoo
name: Kim, Jinwoong
name: Oh, Youri
name: Jang, Miyoung
name: Hah, Jung-Mi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT3-ITD. Compound 7d, 5-methyl-N-(2-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)quinazolin-7-yl)isoxazole-4-carboxamide, exhibited the most potent inhibitory activity against FLT3 (IC50= 106 nM) with excellent selectivity profiles over 36 other protein kinases including cKit and FMS kinase. Compound 7d was also active in FLT-ITD, with an IC50 value of 301 nM, and other FLT3 mutants showing potential as an AML therapeutics.
Numerische 3D-CFD-Simulation des Dual-Fuel-Brennverfahrens für maritime Anwendungen unter Verwendung detaillierter Reaktionsmechanismen
Creators: name: Andree, Sascha
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 600 Technology (Applied sciences)
subject: 620 Engineering & allied operations
subject: 624 Structural and Environmental Engineering

description: Das Ziel dieser Arbeit bestand darin, eine Methodik zu entwickeln, mit der Dual-Fuel-Schiffsdieselmotoren simuliert werden können. Aufgrund der monovalenten Kraftstofffähigkeit gängiger Verbrennungsmodelle wurde ein FGM-Ansatz mit tabellierter Reaktionskinetik gewählt. Dafür wurde ein geeigneter Reaktionsmechanismus erstellt und validiert. Im Weiteren ist ein 3-D CFD-Modell erstellt und anhand von Messdaten eines Einzylinder-Schiffsdiesel-Forschungsmotors validiert worden.
Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model
Creators: name: Du, Xiu-Jiang
name: Peng, Xing-Jie
name: Zhao, Rui-Qi
name: Zhao, Wei-Guang
name: Dong, Wei-Li
name: Liu, Xing-Hai
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro and in vivo. Interestingly, compound I-1, I-2, I-3, I-6 and I-7 exhibited moderate control effect (>50%) against Pseudoperonospora cubensis in greenhouse at 6.25 μg/mL, which is better than that of control. Meanwhile most of these compounds exhibited significant inhibitory against P. capsici. The other nine fungi were also tested. More importantly, some compounds exhibited remarkably high activities against Sclerotinia sclerotiorum, P. piricola and R. solan in vitro with EC50 values of 3.74–9.76 μg/mL. It is possible that the model is reliabile and this method can be used to discover lead compounds for the development of fungicides.
РУССКАЯ ЛИТЕРАТУРА В СВЕТЕ ИССЛЕДОВАТЕЛЬСКИХ ПАРАДИГМ: О ДИССЕРТАЦИЯХ 2022 ГОДА
Creators: name: Лебединская, Виктория
Publisher: name: ООО Цифра
Year: 2023
Subjects: Russian literature
scientific paradigm
axiology
русская литература
научная парадигма
аксиология

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Centralized and partial decentralized design for the Fog Radio Access Network
Creators: name: Chen, Di
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 000 Generalities, Science
subject: 004 Data processing Computer sciences
subject: 621.3 Electrical Engineering, Electronics

description: Fog Radio Access Network (F-RAN) has been shown to be a promising network architecture for the 5G network. With F-RAN, certain amount of signal processing functionalities are pushed from the Base Station (BS) on the network edge to the BaseBand Units (BBU) pool located remotely in the cloud. Hence, partially centralized network operation and management can be achieved, which can greatly improve the energy and spectral efficiency of the network, in order to meet the requirements of 5G. In this work, the optimal design for both uplink and downlink of F-RAN are intensively investigated.
Additional file 2 of Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study
Creators: name: Adank, Maria C.
name: Benschop, Laura
name: Streun, Sophia P. Van
name: Gregoor, Anna M. Smak
name: Mulder, Monique T.
name: Steegers, Eric A. P.
name: Schalekamp-Timmermans, Sarah
name: Lennep, Jeanine E. Roeters Van
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 2. STROBE statement.
General model selection estimation of a periodic regression with a Gaussian noise
Creators: name: Konev, Victor
name: Pergamenchtchikov, Serguei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: This paper considers the problem of estimating a periodic function in a continuous time regression model with an additive stationary gaussian noise having unknown correlation function. A general model selection procedure on the basis of arbitrary projective estimates, which does not need the knowledge of the noise correlation function, is proposed. A non-asymptotic upper bound for quadratic risk (oracle inequality) has been derived under mild conditions on the noise. For the Ornstein-Uhlenbeck noise the risk upper bound is shown to be uniform in the nuisance parameter. In the case of gaussian white noise the constructed procedure has some advantages as compared with the procedure based on the least squares estimates (LSE). The asymptotic minimaxity of the estimates has been proved. The proposed model selection scheme is extended also to the estimation problem based on the discrete data applicably to the situation when high frequency sampling can not be provided.
Additional file 1 of Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study
Creators: name: Adank, Maria C.
name: Benschop, Laura
name: Streun, Sophia P. Van
name: Gregoor, Anna M. Smak
name: Mulder, Monique T.
name: Steegers, Eric A. P.
name: Schalekamp-Timmermans, Sarah
name: Lennep, Jeanine E. Roeters Van
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Table S1. Association of maternal lipid profile in early pregnancy with their corresponding lipid levels six years later (n = 3510). Table S2. Baseline characteristics of women with and without available lipid measurements six years after pregnancy.
The application of Shifted Frequency Analysis in power system transient stability studies
Creators: name: Martí, Andrea T.J.
Publisher: name: University of British Columbia
Year: 2018

description: Power system engineers use transient stability computer simulation programs to model the power grid’s behaviour when large disruptions cause the grid to deviate from its 60-Hz operating frequency. These programs must be able to capture these frequency dynamics around 60 Hz while being computationally efficient, as an extensive number of simulations are typically run for a given scenario. In the traditional power grid, the large mechanical inertia of the synchronous generators stabilizes the network during disturbances and maintains the system frequency close to the 60 Hz operating frequency. In the modern grid, however, the increase of renewable energy sources lowers the grid’s inertia and larger frequency deviations can occur. The phasor solution method employed in the traditional programs solves the network assuming a constant 60-Hz frequency. When deviations from 60 Hz are prominent, the Electromagnetic Transients Program (EMTP) is used as an alternative to the phasor solution to capture these fluctuations. The EMTP models the electrical network based on the differential equations of the network components, which allows the tracing of the network waveforms. However, this discretization requires small time-steps, which makes the solution method computationally expensive. The Shifted Frequency Analysis (SFA) method discussed in this work is an alternative to the traditional phasor solution and to the EMTP solution. In this work, a generalized SFA-based program is written and used for transient stability analysis. SFA is a discrete-time solution method, like the EMTP, but uses a frequency-shifting transformation to bring the solution domain down to 0 Hz. Because of this transformation, SFA can capture network dynamics around 60 Hz using large time-steps, making it suitable for transient stability analysis studies.
Extraktion und Integration heterogener unstrukturierter und semistrukturierter Daten für die Tarifierung von gewerblichen Gebäudeversicherungen
Creators: name: Ghashghaie, Sina
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 004 Data processing Computer sciences
subject: 080 General collections
subject: 400 Language, Linguistics

description: In dieser Masterarbeit geht es um die dynamische Information-Extraktion (IE) und Integration heterogener unstrukturierter und semistrukturierter Daten für die Tarifierung der gewerblichen Gebäude-Versicherungen bei der SkenData GmbH. Integriert werden die Daten in einer strukturierten JavaScript Object Notation (JSON)-Datei. Der Leser erhält damit auch einen Überblick über verwandte Arbeiten und die Herausforderungen bei der Extraktion der Informationen aus semistrukturierten Daten bzw. Datenquellen und damit speziell aus deutschsprachigen gewerblichen Texten.
Surface structure, stability and activity of molybdenum carbides supported transition metal catalysts
Creators: name: Wang, Fan
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 540 Chemistry & allied sciences

description: Der zentrale Punkt dieser Dissertation ist eine theoretische Untersuchung der Struktur, Stabilität und Aktivität von Übergangsmetallen (Fe, Co, Ni, Cu, Pd und Pt), die auf den unterschiedlichen Oberflächen der hexagonalen ß-Mo2C und kubischen-δ-MoC Phasen abgelagert sind. Es zeigt sich, dass Struktur und Stabilität von Trägerkatalysatoren durch die Eigenschiften der Übergangsmetalle und deren Wechselwirkung mit den Carbidoberflächen bestimmt werden und von der Metallbeladung abhängig sind; und dies wiederum bestimmt die Aktivität der katalytischen Reaktionen.
null Bedeutung der Methämoglobinkonzentration als möglicher perioperativer Marker für Mikrozirkulationsstörungen, Ischämien und Anämien
Creators: name: Heusinger von Waldegg, Tim
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Diese Arbeit hat sich zum Ziel gesetzt, die perioperative Methämoglobinkonzentration von Patienten, die sich großen abdominalchirurgischen Eingriffen unterzogen haben, auf eine Korrelation mit der substituierten Volumentherapie zu untersuchen. Ebenfalls wurde ein Vergleich dieser mit gängigen Parametern, die Mikrozirkulationsstörungen und Ischämien darstellen, durchgeführt. Als Methämoglobinmonitoring wurde dabei neben dem Standard via BGA auch ein modernes pulsoximetrisches kontinuierliches Messverfahren verwendet und diese miteinander verglichen.