cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells
Creators: name: Marjoram,
name: Guilluy,
name: Burridge,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Cellular tension has implications in normal biology and pathology. Membrane adhesion receptors serve as conduits for mechanotransduction that lead to cellular responses. Ligand-conjugated magnetic beads are a useful tool in the study of how cells sense and respond to tension. Here we detail methods for their use in applying tension to cells and strategies for analyzing the results. We demonstrate the methods by analyzing mechanotransduction through VE-cadherin on endothelial cells using both permanent magnets and magnetic tweezers.
Relative BGG sequences; I. Algebra
Creators: name: Cap, Andreas
name: Soucek, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 17B20 (Primary), 17B10, 17B55 (Secondary)

description: We develop a relative version of Kostant's harmonic theory and use this to prove a relative version of Kostant's theorem on Lie algebra (co)homology. These are associated to two nested parabolic subalgebras in a semisimple Lie algebra. We show how relative homology groups can be used to realize representations with lowest weight in one (regular or singular) affine Weyl orbit. In the regular case, we show how all the weights in the orbit can be realized as relative homology groups (with different coefficients). These results are motivated by applications to differential geometry and the construction of invariant differential operators.
description: 21 pages, comments are welcome; v3: final version to appear in J. Algebra
Sticherus lanuginosus Nakai, Bull. Natl. Sci. Mus.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Gleicheniales
Gleicheniaceae
Sticherus
Sticherus lanuginosus

description: Sticherus lanuginosus (Fée) Nakai, Bull. Natl. Sci. Mus. 29: 20. 1950.
 Range: —Hispaniola; Costa Rica to Venezuela and Bolivia (CO, LP, SC); central and eastern Brazil and eastern Paraguay.
 Ecology: —Common; montane pastures and savannas, especially in burnt habitats; 800–3000 m.
 Notes: —Varies considerably in size, with specimens from dry and sunny (and also perhaps from nutrient-poor) sites smaller, with more closely held branches, and more coriaceous segments with more strongly revolute margins. Formerly widely known as S. penniger (Mart.) Copel. (= Gleichenia pennigera (Mart.) T.Moore), but that name is now known to apply to a different Brazilian species.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XI. Gleicheniaceae, pp. 53-63 in Phytotaxa 344 (1) on page 59, DOI: 10.11646/phytotaxa.344.1.7, http://zenodo.org/record/13720573
Assays for Post-translational Modifications of Intermediate Filament Proteins
Creators: name: Omary, M. Bishr
name: Snider, Natasha T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Intermediate filament (IF) proteins are known to be regulated by a number of post-translational modifications (PTMs). Phosphorylation is the best studied IF PTM, whereas ubiquitination, sumoylation, acetylation, glycosylation, ADP-ribosylation, farnesylation and transamidation are less understood in functional terms but are known to regulate specific IFs under various contexts. The number and diversity of IF PTMs is certain to grow along with rapid advances in proteomic technologies. Therefore, the need for a greater understanding of the implications of PTMs to the structure, organization, and function of the IF cytoskeleton has become more apparent with the increased availability of data from global profiling studies of normal and diseased specimens. This chapter will provide information on established methods for the isolation and monitoring of IF PTMs along with the key reagents that are necessary to carry out these experiments.
Data analytics, self-organization, and security provisioning for smart monitoring systems
Creators: name: Waseem Anwar, Raja
name: Qureshi, Kashif Naseer
name: Nagmeldin, Wamda
name: Abdelmaboud, Abdelzahir
name: Zrar Ghafoor, Kayhan
name: Javed, Ibrahim Tariq
name: Crespi, Noel
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 40
subject: Engineering

description: Internet availability and its integration with smart technologies have favored everyday objects and things and offered new areas, such as the Internet of Things (IoT). IoT refers to a concept where smart devices or things are connected and create a network. This new area has suffered from big data handling and security issues. There is a need to design a data analytics model by using new 5G technologies, architecture, and a security model. Reliable data communication in the presence of legitimate nodes is always one of the challenges in these networks. Malicious nodes are generating inaccurate information and breach the user’s security. In this paper, a data analytics model and self-organizing architecture for IoT networks are proposed to understand the different layers of technologies and processes. The proposed model is designed for smart environmental monitoring systems. This paper also proposes a security model based on an authentication, detection, and prediction mechanism for IoT networks. The proposed model enhances security and protects the network from DoS and DDoS attacks. The proposed model evaluates in terms of accuracy, sensitivity, and specificity by using machine learning algorithms.
Sticherus pruinosus Nakai, Bull. Natl. Sci. Mus.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Gleicheniales
Gleicheniaceae
Sticherus
Sticherus pruinosus

description: Sticherus pruinosus (Mart.) Nakai, Bull. Natl. Sci. Mus. 29: 25. 1950.
 Range: —Andes from Ecuador to Bolivia (LP, SC); southeastern Brazil.
 Ecology: —Uncommon; open habitats in humid forests; 1500–2250 m, elsewhere at (100?) 700–2450 m.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XI. Gleicheniaceae, pp. 53-63 in Phytotaxa 344 (1) on page 60, DOI: 10.11646/phytotaxa.344.1.7, http://zenodo.org/record/13720573
Engineering and Application of LOV2-based Photoswitches
Creators: name: Kuhlman,
name: Yumerefendi,
name: Zimmerman,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Cellular optogenetic switches, a novel class of biological tools, have improved our understanding of biological phenomena that were previously intractable. While the design and engineering of these proteins has historically varied they are all based on borrowed elements from plant and bacterial photoreceptors. In general terms, each of the optogenetic switches designed to date exploits the endogenous light induced change in photoreceptor conformation while repurposing its effect to target a different biological phenomena. We focus on the well-characterized Light Oxygen Voltage 2 (LOV2) domain from Avena sativa phototropin 1 as our cornerstone for design. While the function of the LOV2 domain in the context of the phototropin protein is not fully elucidated, its thorough biophysical characterization as an isolated domain has created a strong foundation for engineering of photoswitches. In this chapter, we examine the biophysical characteristics of the LOV2 domain that may be exploited to produce an optogenetic protein and summarize previous design efforts to provide guidelines for an effective design. Furthermore, we provide protocols for assays including fluorescent polarization, phage display, and microscopy that are optimized for validating, improving, and using newly designed photoswitches.
International Enforcement of Human Rights: Potency and Strategies
Creators: name: Wasiq, Mohammad Rasikh
Publisher: name: figshare
Year: 2023
Subjects: Conflict of laws (incl. private international law)
Public international law
International criminal law
International and comparative law not elsewhere classified
International trade and investment law
International humanitarian and human rights law

description: Humans have the same dignity and rights as other creatures from the moment they are born. They have reason and conscience, and they should treat each other with brotherly affection." At their most fundamental level, human rights are a product of democracy. In general, humanity's fight against authoritarianism and injustice has been lengthy and unending. Throughout history, tyranny has taken on many different forms and strategies. Man has sought to secure his rights several times; occasionally he has failed horribly, and the assault on human rights continues. Man's struggle against oppression is analogous. The true notion of human rights and its enforcement began to take shape in the west during this age only during the Renaissance and the industrialization process. The Treaty Bodies associated with the current seven active treaties, as well as the Human Rights Council complaints procedures, are examples of them. It is the role of the Nation-State to enforce international human rights law, and it is the State's primary responsibility to make human rights a reality. Many human rights are difficult to enforce legally in practice due to a lack of consensus on how to apply them, as well as a lack of relevant national legislation or agencies with the authority to take legal action to enforce them. This study aims to address the numerous dimensions of human rights protection, including its legal, social, political, and economic aspects.
Tracking of colloids close to contact
Creators: name: Zhang, Chi
name: Brügger, Georges
name: Scheffold, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The precise tracking of micron sized colloidal particles - held in the vicinity of each other using optical tweezers - is an elegant way to gain information about the particle-particle pair interaction potential. The accuracy of the method, however, relies strongly on the tracking precision. Particularly the elimination of systematic errors in the position detection due to overlapping particle diffraction patterns remains a great challenge. Here we propose a template based particle finding algorithm that circumvents these problems by tracking only a fraction of the particle image that is insignificantly affected by nearby colloids. Under realistic experimental conditions we show that our algorithm significantly reduces systematic errors compared to standard tracking methods. Moreover our approach should in principle be applicable to almost arbitrary shaped particles as the template can be adapted to any geometry.
description: 8 pages, 4 figures
Single-Molecule FRET to Measure Conformational Dynamics of DNA Mismatch Repair Proteins
Creators: name: Erie,
name: Hingorani,
name: Weninger,
name: Sakato,
name: Case,
name: Qiu,
name: Hao,
name: Gauer,
name: LeBlanc,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Single-molecule FRET measurements have a unique sensitivity to protein conformational dynamics. The FRET signals can either be interpreted quantitatively to provide estimates of absolute distance in a molecule configuration or can be qualitatively interpreted as distinct states, from which quantitative kinetic schemes for conformational transitions can be deduced. Here we describe methods utilizing single-molecule FRET to reveal the conformational dynamics of the proteins responsible for DNA mismatch repair. Experimental details about the proteins, DNA substrates, fluorescent labeling, and data analysis are included. The complementarity of single molecule and ensemble kinetic methods is discussed as well.
Aperiodic Weak Topological Superconductors
Creators: name: Fulga, I. C.
name: Pikulin, D. I.
name: Loring, T. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Weak topological phases are usually described in terms of protection by the lattice translation symmetry. Their characterization explicitly relies on periodicity since weak invariants are expressed in terms of the momentum-space torus. We prove the compatibility of weak topological superconductors with aperiodic systems, such as quasicrystals. We go beyond usual descriptions of weak topological phases and introduce a novel, real-space formulation of the weak invariant, based on the Clifford pseudospectrum. A non-trivial value of this index implies a non-trivial bulk phase, which is robust against disorder and hosts localized zero-energy modes at the edge. Our recipe for determining the weak invariant is directly applicable to any finite-sized system, including disordered lattice models. This direct method enables a quantitative analysis of the level of disorder the topological protection can withstand.
description: 5 pages, 2 figures + 4 pages, 4 figures appendix. This is the final, published version
title: Wachstumsverhalten von Spiralganglienzellen auf Calciumphosphat-Nanopartikeln
Creators: name: Hansen, Stefan
name: Holtmann, Laura
name: Schirrmann, Ronja
name: Wey, Karolin
name: Epple, Matthias
name: Lang, Stephan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Calciumphosphat-Nanopartikel (CaP-NP) können als Trägersubstanz für Medikamente, Proteine und sogar Nukleinsäuren dienen. Sie durchdringen die Membran einer Zielzelle, so dass ihre jeweiligen Konjugate eine intrazelluläre Wirkung entfalten können. So kann beispielsweise[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Effect of Inter-Modular Connection on Fast Sparse Synchronization in Clustered Small-World Neural Networks
Creators: name: Kim, Sang-Yoon
name: Lim, Woochang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We consider a clustered network with small-world sub-networks of inhibitory fast spiking interneurons, and investigate the effect of inter-modular connection on emergence of fast sparsely synchronized rhythms by varying both the inter-modular coupling strength $J_{inter}$ and the average number of inter-modular links per interneuron $M_{syn}^{(inter)}$. In contrast to the case of non-clustered networks, two kinds of sparsely synchronized states such as modular and global synchronization are found. For the case of modular sparse synchronization, the population behavior reveals the modular structure, because the intra-modular dynamics of sub-networks make some mismatching. On the other hand, in the case of global sparse synchronization, the population behavior is globally identical, independently of the cluster structure, because the intra-modular dynamics of sub-networks make perfect matching. We introduce a realistic cross-correlation modularity measure, representing the matching-degree between the instantaneous sub-population spike rates of the sub-networks, and examine whether the sparse synchronization is global or modular. Furthermore, we characterize the modular and global sparse synchronization by employing the realistic sub- and whole-population order parameters and statistical-mechanical measures. The roles of $J_{inter}$ and $M_{syn}^{(inter)}$ are thus found as follows. For large $J_{inter}$, due to strong inhibition it plays a destructive role to "spoil" the pacing between spikes, while for small $J_{inter}$ it plays a constructive role to "favor" the pacing between spikes. In contrast, $M_{syn}^{(inter)}$ seems to play a role just to favor the pacing between spikes. With increasing $M_{syn}^{(inter)}$, the pacing degree between spikes increases monotonically thanks to the increase in the degree of effectiveness of global communication between spikes.
Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray
Creators: name: Trievel,
name: Strahl,
name: Rothbart,
name: Vaughan,
name: Cornett,
name: Krishnan,
name: Dickson,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The dynamic addition and removal of covalent posttranslational modifications (PTMs) on histone proteins serves as a major mechanism regulating chromatin-templated biological processes in eukaryotic genomes. Histone PTMs and their combinations function by directly altering the physical structure of chromatin and as rheostats for effector protein interactions. In this chapter, we detail microarray-based methods for analyzing the substrate specificity of lysine methyltransferase and demethylase enzymes on immobilized synthetic histone peptides. Consistent with the “histone code” hypothesis, we reveal a strong influenceof adjacent and,surprisingly,distant histonePTMs onthe ability of histone-modifying enzymes to methylate or demethylate their substrates. This platform will greatly facilitate future investigations into histone substrate specificity and mechanisms of PTM signaling that regulate the catalytic properties of histone-modifying enzymes.
Uffizi TikTok Analytics - Grafici distribuzione video
Creators: name: Falorni, Elisabetta
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 470101
subject: Communication studies

description: Grafici rappresentanti la distribuzione di un campione di 115 video, pubblicati sull'account istituzione delle Gallerie degli Uffizi, in varie categorie contenutistiche.
Functional Study of the Vitamin K Cycle Enzymes in Live Cells
Creators: name: Tie,
name: Stafford,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Vitamin K-dependent carboxylation, an essential posttranslational modification catalyzed by gamma-glutamyl carboxylase, is required for the biological functions of proteins that control blood coagulation, vascular calcification, bone metabolism, and other important physiological processes. Concomitant with carboxylation, reduced vitamin K (KH2) is oxidized to vitamin K epoxide (KO). KO must be recycled back to KH2 by the enzymes vitamin K epoxide reductase and vitamin K reductase in a pathway known as the vitamin K cycle. Our current knowledge about the enzymes of the vitamin K cycle is mainly based on in vitro studies of each individual enzymes under artificial conditions, which are of limited usefulness in understanding how the complex carboxylation process is carried out in the physiological environment. In this chapter, we review the current in vitro activity assays for vitamin K cycle enzymes. We describe the rationale, establishment, and application of cell-based assays for the functional study of these enzymes in the native cellular milieu. In these cell-based assays, different vitamin K-dependent proteins were designed and stably expressed in mammalian cells as reporter proteins to accommodate the readily used enzyme-linked immunosorbent assay for carboxylation efficiency evaluation. Additionally, recently emerged genome-editing techniques TALENs and CRISPR-Cas9 were used to knock out the endogenous enzymes in the reporter cell lines to eliminate the background. These cell-based assays are easy to scale up for high-throughput screening of inhibitors of vitamin K cycle enzymes and have been successfully used to clarify the genotypes and their clinical phenotypes of enzymes of the vitamin K cycle.
Using Atomic Force Microscopy to Characterize the Conformational Properties of Proteins and Protein–DNA Complexes That Carry Out DNA Repair
Creators: name: Li, Zimeng
name: LeBlanc, Sharonda
name: Kaur, Parminder
name: Wang, Hong
name: Wilkins, Hunter
name: Erie, Dorothy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Atomic force microscopy (AFM) is a scanning probe technique that allows visualization of single biomolecules and complexes deposited on a surface with nanometer resolution. AFM is a powerful tool for characterizing protein–protein and protein–DNA interactions. It can be used to capture snapshots of protein–DNA solution dynamics, which in turn, enables the characterization of the conformational properties of transient protein–protein and protein–DNA interactions. With AFM, it is possible to determine the stoichiometries and binding affinities of protein–protein and protein–DNA associations, the specificity of proteins binding to specific sites on DNA, and the conformations of the complexes. We describe methods to prepare and deposit samples, including surface treatments for optimal depositions, and how to quantitatively analyze images. We also discuss a new electrostatic force imaging technique called DREEM, which allows the visualization of the path of DNA within proteins in protein–DNA complexes. Collectively, these methods facilitate the development of comprehensive models of DNA repair and provide a broader understanding of all protein–protein and protein–nucleic acid interactions. The structural details gleaned from analysis of AFM images coupled with biochemistry provide vital information toward establishing the structure–function relationships that govern DNA repair processes.
The Need, Benefits, and Demonstration of a Minimization Principle for Excited States
Creators: name: Bacalis, Naoum C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: It is shown that the standard methods of computing excited states in truncated spaces must yield wave functions that, beyond truncation, are in principle veered away from the exact, and a remedy is demonstrated via a presented functional, F$_n$, obeying a minimization principle for excited states. It is further demonstrated that near avoided crossings, between two MCSCF 'flipped roots' the wave function that leads to the excited state has the lowest F$_n$.
description: 4 pages, 1 figure, International Conference of Computational Methods in Sciences and Engineering - 2015 / Computational Chemistry, 20-23 March 2015, Athens, GREECE
Pleione jinhuana Z. J. Liu, M. T. Jiang & S. R. Lan 2018, sp. nov.
Creators: name: Jiang, Ming-Tao
name: Wu, Sha-Sha
name: Liu, Zhong-Jian
name: Lan, Si-Ren
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Pleione
Pleione jinhuana

description: Pleione jinhuana Z.J.Liu, M.T.Jiang & S.R.Lan, sp. nov. (ḮĻÊĬĔ, Figs. 3, 4)
 Type:— CHINA. Zhejiang (Ṁã): Jinhua (ḮĻ), on the slopes of evergreen broad-leaved forests, 1100 m, 24 April 2013, Liu 7084 (holotype NOCC!; isotype NOCC!).
 This new species is similar to P. bulbocodioides and P. formosana but differs from them by having a lip with an erose apical margin and lateral lobes of the lip not enfolding the column. In addition, it can be distinguished from P. bulbocodioides by having two calluses and from P. formosana by having conical pseudobulbs and narrower sepals and petals.
Lithophytic herbs with dark green, ovoid pseudobulbs, 2.3–2.8 × 1.4–1.7 cm, each bearing a single leaf. Leaf developing at anthesis, elliptic-lanceolate, base attenuate into a petiole-like stalk 1.0–4.0 cm, apex acute. Inflorescence erect; peduncle ca. 6.0 cm, with 2 sheaths at base; flowers pale purple, with purple marks on the middle and apical regions of lip; ovary ca. 1.0 cm. Floral bracts narrowly elliptic, ca. 2.0 × 0.5 cm, exceeding ovary, apex acute. Dorsal sepal spatulate-oblanceolate, 4.1–4.5 × 0.5–0.6 cm, apex acute; lateral sepals narrowly elliptic-oblanceolate, slightly oblique, 4.0–4.5 × 0.7–0.9 cm, apex subacute. Petals linear-oblanceolate, 4.0–4.8 × 0.4–0.5 mm, apex subacute; lip broadly elliptic when flattened, 4.0–5.1 × 2.5–3.3 cm, apical margin erose, lateral lobes not enfolding the column, callus consisting of 2 interrupted lamellae with yellowish, erose margins and purple marks on the middle and apical regions of lip. Column ca. 3.3 cm, apex obscurely toothed.
 Phenology:— Flowering April to May.
 Distribution and Habitat: — Pleione jinhuana is lithophytic on the slopes of evergreen broad-leaved forests at 1100 m in Jinhua, Zhejiang Province, China.
 Etymology: —The specific epithet refers to the locality where this new species was first found.
description: Published as part of Jiang, Ming-Tao, Wu, Sha-Sha, Liu, Zhong-Jian & Lan, Si-Ren, 2018, Pleione jinhuana (Arethuseae; Epidendroideae; Orchidaceae), a new species from China based on morphological and DNA evidence, pp. 43-50 in Phytotaxa 345 (1) on pages 48-49, DOI: 10.11646/phytotaxa.345.1.5, http://zenodo.org/record/13720585
Moving towards adaptive management of cyanotoxin-impaired water bodies
Creators: name: Paerl, Hans W.
name: Otten, Timothy G.
name: Joyner, Alan R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The cyanobacteria are a phylum of bacteria that have played a key role in shaping the Earth's biosphere due to their pioneering ability to perform oxygenic photosynthesis. Throughout their history, cyanobacteria have experienced major biogeochemical changes accompanying Earth's geochemical evolution over the past 2.5+ billion years, including periods of extreme climatic change, hydrologic, nutrient and radiation stress. Today, they remain remarkably successful, exploiting human nutrient over-enrichment as nuisance "blooms." Cyanobacteria produce an array of unique metabolites, the functions and biotic ramifications of which are the subject of diverse ecophysiological studies. These metabolites are relevant from organismal and ecosystem function perspectives because some can be toxic and fatal to diverse biota, including zooplankton and fish consumers of algal biomass, and high-level consumers of aquatic food sources and drinking water, including humans. Given the long history of environmental extremes and selection pressures that cyanobacteria have experienced, it is likely that that these toxins serve ecophysiological functions aimed at optimizing growth and fitness during periods of environmental stress. Here, we explore the molecular and ecophysiological mechanisms underlying cyanotoxin production, with emphasis on key environmental conditions potentially controlling toxin production. Based on this information, we offer potential management strategies for reducing cyanotoxin potentials in natural waters; for cyanotoxins with no clear drivers yet elucidated, we highlight the data gaps and research questions that are still lacking. We focus on the four major classes of toxins (anatoxins, cylindrospermopsins, microcystins and saxitoxins) that have thus far been identified as relevant from environmental health perspectives, but caution there may be other harmful metabolites waiting to be elucidated.
title: Gesundheitsbezogene Lebensqualität nach Vestibularisschwannomentfernung
Creators: name: Glaas, Marcel
name: Schäfer, Ralf
name: Franz, Matthias
name: Schipper, Jörg
name: Kristin, Julia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die gesundheitsbezogene Lebensqualität (HRQOL) gewinnt in allen medizinischen Bereichen immer mehr an Bedeutung. Zur Evaluation der Lebensqualität von Patienten mit Vestibularisschwannom (VS) können allgemeine (z.B. SF-36) oder krankheitsspezifische Fragebögen (z.B. PANQOL)[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Critical value for the contact process with random edge weights on regular tree
Creators: name: Xue, Xiaofeng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: In this paper we are concerned with contact processes with random edge weights on rooted regular trees. We assign i.i.d weights on each edge on the tree and assume that an infected vertex infects its healthy neighbor at rate proportional to the weight on the edge connecting them. Under the annealed measure, we define the critical value λ_c as the maximum of the infection rate with which the process will die out and define λ_e as the maximum of the infection rate with which the process dies out at exponential rate. We show that these two critical values satisfy an identical limit theorem and give an precise lower bound of λ_e. We also study the critical value under the quenched measure. We show that this critical value equals that under the annealed measure or infinity according to a dichotomy criterion. The contact process on a Galton-Watson tree with binomial offspring distribution is a special case of our model.
description: 21 pages
Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs
Creators: name: Hassan, Bachar
name: Li, Xing-Ping
name: Li, Jun
name: Sun, Jian
name: Feng, Youjun
name: Wang, Qingjing
name: Ding, Youfa
name: Lin, Jingxia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use.

METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing. PCR was applied to close the gap of the assembled contigs. Ori-Finder was employed to predict the replication origin (oriC) in plasmids. The phenotype of MCR-1-producing isolates was evaluated on the LBA plates with various level of colistin. Genetic deletion was used to test the requirement of the initial "ATG" codon for the MCR-1 function.

RESULTS: Here, we report full genomes of over 10 mcr-1-harboring plasmids with diversified replication incompatibilities. A novel hybrid IncI2/IncFIB plasmid pGD17-2 was discovered and characterized from a swine isolate with colistin resistance. Intriguingly, co-occurrence of two unique mcr-1-bearing plasmids (pGD65-3, IncI2, and pGD65-5, IncX4) was detected in a single isolate GD65, which might accelerate dissemination of the mcr-1 under environmental selection pressure. Genetic analyses of these plasmids mapped mobile elements in the context of antibiotic resistance and determined two insertion sequences (ISEcp1 and ISApl1) that are responsible for the mobilization of mcr-1. Gene deletion also proved that the first ATG codon is redundant in the mcr-1 gene.

CONCLUSIONS: Collectively, our results extend landscapes of the diversified mcr-1-bearing plasmid reservoirs.
Gauge and motion in perturbation theory
Creators: name: Pound, Adam
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Through second order in perturbative general relativity, a small compact object in an external vacuum spacetime obeys a generalized equivalence principle: although it is accelerated with respect to the external background geometry, it is in free fall with respect to a certain \emph{effective} vacuum geometry. However, this single principle takes very different mathematical forms, with very different behaviors, depending on how one treats perturbed motion. Furthermore, any description of perturbed motion can be altered by a gauge transformation. In this paper, I clarify the relationship between two treatments of perturbed motion and the gauge freedom in each. I first show explicitly how one common treatment, called the Gralla-Wald approximation, can be derived from a second, called the self-consistent approximation. I next present a general treatment of smooth gauge transformations in both approximations, in which I emphasise that the approximations' governing equations can be formulated in an invariant manner. All of these analyses are carried through second perturbative order, but the methods are general enough to go to any order. Furthermore, the tools I develop, and many of the results, should have broad applicability to any description of perturbed motion, including osculating-geodesic and two-timescale descriptions.
description: 26 pages, 3 figures. Minor corrections. Equations (120) and (126) are more general than in PRD version
title: Rasch progredienter einseitiger Hörverlust bei kontralateraler Surditas, eine seltene Manifestation der Neurosarkoidose
Creators: name: Kaster, Friederike
name: Arnolds, Judith
name: Lang, Stephan
name: Arweiler-Harbeck, Diana
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Neurosarkoidose ist eine seltene Erkrankung (Inzidenz 0,4-0,5/100000 Einwohner), noch seltener ist die Erstmanifestation als progredienter Hörverlust. Klinisch manifestiert sich die Neurosarkoidose am häufigsten (50-70%) mit multiplen Hirnnervenausfällen, bei denen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
title: Nanopartikel als Drug-Delivery-Systeme in der HNO. Ist ein sicherer Einsatz Cetuximab-konjugierter Calciumphosphat Nanopartikel möglich?
Creators: name: Eyth, Christian P.
name: Hansen, Stefan
name: Bruderek, Kirsten
name: Schirrmann, Ronja
name: Altenhoff, Petra
name: Wey, Karolin
name: Kollenda, Sebastian
name: Hackel, Alexander
name: Vollmer, Sebastian
name: Lang, Stephan
name: Epple, Matthias
name: Brandau, Sven
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Nanopartikel finden bereits heute für viele medizinische und technische Applikationen Anwendung. Insbesondere der Einsatz als Arzneimittelträger rückt zunehmend in den Fokus der Grundlagenforschung. Die Einsatzmöglichkeiten reichen hierbei von der Modulation anti-inflammatorischer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Detail-preserving and Content-aware Variational Multi-view Stereo Reconstruction
Creators: name: Li, Zhaoxin
name: Wang, Kuanquan
name: Zuo, Wangmeng
name: Meng, Deyu
name: Zhang, Lei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Accurate recovery of 3D geometrical surfaces from calibrated 2D multi-view images is a fundamental yet active research area in computer vision. Despite the steady progress in multi-view stereo reconstruction, most existing methods are still limited in recovering fine-scale details and sharp features while suppressing noises, and may fail in reconstructing regions with few textures. To address these limitations, this paper presents a Detail-preserving and Content-aware Variational (DCV) multi-view stereo method, which reconstructs the 3D surface by alternating between reprojection error minimization and mesh denoising. In reprojection error minimization, we propose a novel inter-image similarity measure, which is effective to preserve fine-scale details of the reconstructed surface and builds a connection between guided image filtering and image registration. In mesh denoising, we propose a content-aware $\ell_{p}$-minimization algorithm by adaptively estimating the $p$ value and regularization parameters based on the current input. It is much more promising in suppressing noise while preserving sharp features than conventional isotropic mesh smoothing. Experimental results on benchmark datasets demonstrate that our DCV method is capable of recovering more surface details, and obtains cleaner and more accurate reconstructions than state-of-the-art methods. In particular, our method achieves the best results among all published methods on the Middlebury dino ring and dino sparse ring datasets in terms of both completeness and accuracy.
description: 14 pages,16 figures. Submitted to IEEE Transaction on image processing
Neurosensory Assessments of Concussion
Creators: name: Tommerdahl, Mark
name: Holden, Jameson K.
name: Favorov, Oleg V.
name: Francisco, Eric M.
name: Nguyen, Richard
name: Dennis, Robert G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: ABSTRACT The purpose of this research was to determine if cortical metrics—a unique set of sensory-based assessment tools—could be used to characterize and differentiate concussed individuals from nonconcussed individuals. Cortical metrics take advantage of the somatotopic relationship between skin and cortex, and the protocols are designed to evoke interactions between adjacent cortical regions to investigate fundamental mechanisms that mediate cortical–cortical interactions. Student athletes, aged 18 to 22 years, were recruited into the study through an athletic training center that made determinations of postconcussion return-to-play status. Sensory-based performance tasks utilizing vibrotactile stimuli applied to tips of the index and middle fingers were administered to test an individual's amplitude discrimination, temporal order judgment, and duration discrimination capacity in the presence and absence of illusion-inducing conditioning stimuli. Comparison of the performances in the presence and abse...
Unusually Large Effects of Charge-assisted C−H⋅⋅⋅F Hydrogen Bonds to Anionic Fluorine in Organic Solvents: Computational Study of 19F NMR Shifts versus Thermochemistry
Creators: name: Kaupp, Martin
name: Schattenberg, Caspar Jonas
name: Müller, Robert
name: Reimann, Marc
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften
subject: NMR chemical shifts
subject: solvation effects
subject: hydrogen bonding
subject: density functional theory
subject: solvation free energy

description: A comparison of computed 19F NMR chemical shifts and experiment provides evidence for large specific solvent effects for fluoride-type anions interacting with the σ*(C−H) orbitals in organic solvents like MeCN or CH2Cl2. We show this for systems ranging from the fluoride ion and the bifluoride ion [FHF]− to polyhalogen anions [ClFx]−. Discrepancies between computed and experimental shifts when using continuum solvent models like COSMO or force-field-based descriptions like the 3D-RISM-SCF model show specific orbital interactions that require a quantum-mechanical treatment of the solvent molecules. This is confirmed by orbital analyses of the shielding constants, while less negatively charged fluorine atoms (e. g., in [EF4]−) do not require such quantum-mechanical treatments to achieve reasonable accuracy. The larger 19F solvent shift of fluoride in MeCN compared to water is due to the larger coordination number in the former. These observations are due to unusually strong charge-assisted C−H⋅⋅⋅F− hydrogen bonds, which manifest beyond some threshold negative natural charge on fluorine of ca. < −0.6 e. The interactions are accompanied by sizable free energies of solvation, in the order F−≫[FHF]−>[ClF2]−>[ClF4]−. COSMO-RS solvation free energies tend to moderately underestimate those from the micro-solvated cluster treatment. Red-shifted and intense vibrational C−H stretching bands, potentially accessible in bulk solution, are further spectroscopic finger prints.
The VIPERS quiescent population - Environmental impact on the mass-size relation
Creators: name: Figueira, M.
name: Siudek, M.
name: Pollo, A.
name: Krywult, J.
Publisher: name: Zenodo
Year: 2023

description: Galaxies are formed from the cooling of baryonic matter into dark matter halos. Depending on the mass and angular momentum of the dark matter halo, the resulting galaxy will have either an elliptical or a spiral morphology. Those two type of galaxies have different properties: elliptical galaxies are redder, more passive, and located in dense environments than their spiral counterparts, which are bluer, star-forming, and found in lower density environment. Several studies of these morphology-density-color relations show that blue star-forming galaxies should experience star-formation quenching and transit to the red and passive population. These quenching mechanisms could either be related to the galaxy (mass quenching) or to the galaxy-galaxy interactions (environmental quenching). The evolution in mass and size of the passive population is still debated nowadays. In this work, I am using the VIMOS Public Extragalactic Redshift Survey to study the mass-size relation of the passive population, to understand how this population evolved from z=0.9 to z=0.5. The sample of passive galaxies is selected from the NUVrK diagram and a distinction is performed between galaxies that were recently quenched and those that already belonged to the red population based on their D4000, a tracer of galaxy’s age. I study the mass size relation over the redshift range of VIPERS to understand the weight of recently quenched galaxies in this relation, what are the drivers of size growth and I compare this relation to the literature, in order to quantify the evolution of the slope and normalization of this relation. I made use of the density computed for each VIPERS galaxy to enhance the study of the mass-size relation in high- and low-density environments. I analyzed how the age of the galaxy, traced by D4000, is changing with mass and radius in different density environment compared to the whole sample. We also show how the different density environments affect the mass-size relation and if the environment is the main driver of the changes observed.
Experiments on MEMS Integration in 0.25 μm CMOS Process
Creators: name: Michalik, Piotr
name: Fernández, Daniel
name: Wietstruck, Matthias
name: Kaynak, Mehmet
name: Madrenas, Jordi
Publisher: name: Basel : MDPI
Year: 2018
Subjects: subject: Accelerometer
subject: BEOL (Back End of Line)
subject: CMOS
subject: CMOS-MEMS
subject: MEMS
subject: 620

description: In this paper, we share our practical experience gained during the development of CMOS-MEMS (Complementary Metal-Oxide Semiconductor Micro Electro Mechanical Systems) devices in IHP SG25 technology. The experimental prototyping process is illustrated with examples of three CMOS-MEMS chips and starts from rough process exploration and characterization, followed by the definition of the useful MEMS design space to finally reach CMOS-MEMS devices with inertial mass up to 4.3 μg and resonance frequency down to 4.35 kHz. Furthermore, the presented design techniques help to avoid several structural and reliability issues such as layer delamination, device stiction, passivation fracture or device cracking due to stress.
title: Rezidivierende juvenile Polyposis nasi – Fallbericht
Creators: name: Bielefeld, Jasmin
name: Neumann, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Es wird über den Krankheitsverlauf einer 16-jährigen Patientin mit seit Jahren bestehender rezidivierender Polyposis nasi und rezidivierenden Nasennebenhöhlenoperationen berichtet. Methoden: Die Patientin stellte sich erstmalig 2013 mit einer klinisch sichtbaren Polyposis[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Structuring experimental data: rethinking data acquisitions to enable replications.
Creators: name: Iacovella, Vittorio
Publisher: name: Zenodo
Year: 2023
Subjects: openscience, opendata, bids, FAIR, FAIRprinciples, Replication, Reproducibility

description: Reproducibility and replicability shape up research routines, starting from data acquisition. Building structured, machine readable data collections is a way to make your research reproducible and foster replication
description: 30' presentation for "Introductory training on open science" with Carlo Miniussi, Marta Bortoletto and Michele Scandola. Verona University (Italy), February 1st 2023
Riemannian metrics on convex sets with applications to Poincaré and log-Sobolev inequalities
Creators: name: Kolesnikov, Alexander V.
name: Milman, Emanuel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Differential Geometry (math.DG)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics

description: Given a probability measure $μ$ supported on a convex subset $Ω$ of Euclidean space $(\mathbb{R}^d,g_0)$, we are interested in obtaining Poincaré and log-Sobolev type inequalities on $(Ω,g_0,μ)$. To this end, we change the metric $g_0$ to a more general Riemannian one $g$, adapted in a certain sense to $μ$, and perform our analysis on $(Ω,g,μ)$. The types of metrics we consider are Hessian metrics (intimately related to associated optimal-transport problems), product metrics (which are very useful when $μ$ is unconditional, i.e. invariant under reflection with respect to the principle hyperplanes), and metrics conformal to the Euclidean one, which have not been previously explored in this context. Invoking on $(Ω,g,μ)$ tools such as Riemannian generalizations of the Brascamp--Lieb inequality and the Bakry--Émery criterion, and passing back to the original Euclidean metric, we obtain various weighted inequalities on $(Ω,g_0,μ)$: refined and entropic versions of the Brascamp--Lieb inequality, weighted Poincaré and log-Sobolev inequalities, Hardy-type inequalities, etc. Key to our analysis is the positivity of the associated Lichnerowicz--Bakry--Émery generalized Ricci curvature tensor, and the convexity of the manifold $(Ω,g,μ)$. In some cases, we can only ensure that the latter manifold is (generalized) mean-convex, resulting in additional boundary terms in our inequalities.
description: 46 pages, to appear in Calc. Var. & PDE
A School-Based Mindfulness Pilot Study for Ethnically Diverse At-Risk Adolescents
Creators: name: Campo, Rebecca A.
name: Mullarkey, Michael
name: Pruteanu-Malinici, Sarah
name: Reams, Amanda
name: Broderick, Patricia C.
name: Bluth, Karen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Adolescence is a critical period for intervention with at-risk youth to promote emotional well-being, deter problematic behavior, and prevent the onset of life-long challenges. Despite preliminary evidence supporting mindfulness interventions for at-risk youth, few studies have included implementation details or reported feasibility and acceptance in ethnically diverse at-risk adolescents in a school setting. We conducted a randomized pilot study of a school-based mindfulness program, Learning to BREATHE, with ethnically diverse at-risk adolescents. Twenty-seven students were randomly assigned to a mindfulness or substance abuse control class that occurred for 50 min, once a week, over one school semester. Adjustments were made to increase acceptability of the mindfulness class, including enhanced instructor engagement in school activities. Reductions in depression were seen for students in the mindfulness class compared to controls. Initially, students’ perceived credibility of the mindfulness class was lower than that of the substance abuse class. Over the semester, perceived credibility of the mindfulness class increased while that of the substance abuse class decreased. Qualitative acceptability measures revealed that the mindfulness class helped to relieve stress and that students favored continuing the class. This study provides practical knowledge about what works with this unique population in a school setting and offers suggestions for future studies.