cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Pièce associée à la lettre de Michel Kazatchkine (ANRS) à J. Leibowitch
Creators: name: Kazatchkine, Michel (1946-....)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: Lipodystrophies

description: Refus du projet Lipodystrophie.
Studies of the nonlinear response of stainless steel structures
Creators: name: Theofanous, Marios
Publisher: name: Imperial College London
Year: 2019

description: Current design guidance on stainless steel structures is largely based on assumed analogies with carbon steel, thereby neglecting stainless steels* actual material behaviour in favour of simplicity. However, its high initial cost warrants the development of improved design guidance which is rational, safe, efficient and in accordance with the actual nonlinear material behaviour. Within the current research project, all reported test data on stainless steel cross- sections (beams and stub columns) have been gathered and utilized to update current European design guidance and to propose alternative novel design methods which account for actual material behaviour and allow for more efficient material use. Existing design methods which allow for the effect of element interaction on cross- section capacity of carbon steel plated sections have been adapted to stainless steel and a modification to the continuous strength method has been proposed, which leads to a significant decrease in the scatter of the predictions. Moreover, the possibility of expanding the scope of the current codified provisions of Eurocode 3: Part 1-4 to new material grades and cross-sections has been investigated through experimental and numerical studies. A series of tests and finite element (FE) analyses on stainless steel Oval Hollow Section (OHS) members was carried out to investigate the structural behaviour of these sections. Similarly, experimental and numerical studies on a new grade of stainless steel with a low nickel content, termed lean duplex stainless steel (EN 1.4162) were also conducted and its applicability for structural applications was verified. Finally, a series of tests on continuous stainless steel beams has been undertaken to investigate the effect of moment redistribution on the capacity of indeterminate stainless steel structures and assess the applicability of nonlinear structural analysis procedures, equivalent to the plastic design of carbon steel structures, to indeterminate stainless steel structures. It was found that plastic design can be safely applied to stainless steel structures and an extension to the continuous strength method has been proposed.
Comparison of all-cause, stroke, and bleed-specific healthcare resource utilization among patients with non-valvular atrial fibrillation (NVAF) and newly treated with dabigatran or warfarin
Creators: name: Song, Xue
name: Gandhi, Pranav
name: Gilligan, Adrienne M.
name: Arora, Prachi
name: Wang, Cheng
name: Henriques, Caroline
name: Sander, Stephen
name: Smith, David M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health
subject: Virology

description: Background: We compared healthcare utilization outcomes and persistence among non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran or warfarin. Methods: Using a nationwide, US administrative claims database, a retrospective matched-cohort of newly diagnosed NVAF patients (age≥18 years) treated with dabigatran or warfarin (propensity score matched 1:1) in 01/01/2011–12/31/2013 was evaluated. All-cause, stroke-, and bleed-specific per patient per month (PPPM) healthcare resource utilization (HCRU), incidence rate of hospitalization for stroke or bleed, 30-day readmission, and persistence were reported. Results: In total, 18,890 dabigatran patients were matched to corresponding warfarin patients. Compared to warfarin users, dabigatran users PPPM had significantly fewer all-cause hospitalizations (0.04 vs 0.05), total outpatient visits (3.98 vs 5.87), and lower 30-day readmissions (14.5% vs 17.4%, all p < 0.001). Dabigatran users had lower incidence rate for stroke (0.65 vs 1.06) and bleed (1.69 vs 2.20), stroke (0.0006 vs 0.0011, p < 0.001) and bleed-specific hospitalizations (0.002 vs 0.003, p = 0.008), and stroke (0.03 vs 0.04, p < 0.001) and bleed-specific outpatient visits (0.07 vs 0.08, p = 0.018), and significantly lower non-persistence (62.1% vs 66.3%, p < 0.001). Conclusion: Among newly diagnosed newly treated NVAF patients, dabigatran users had significantly lower all-cause, stroke- and bleed-specific HCRU, lower risk of hospitalization for stroke or bleed events, lower 30-day readmissions, and higher persistence than warfarin users.
Janson AFIB Survey
Creators: name: Janson, John Peter
name: LaBond, Virginia
Publisher: name: figshare
Year: 2018
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110201 Cardiology (incl. Cardiovascular Diseases)

description: Survey implemented in the research of AFIB protocol benefits in emergency departments.
Growing up as the child of a single mother in London from 1943
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: I was born in Forest Gate Hospital on 11 October 1943. I remember virtually nothing of the actual war but want to speak up for all those who suffered the impact of the war, which resulted in family breakups. My mother was about to get engaged when war broke out. Her fiancé joined up and found someone else, leaving my mother stranded as a single parent. In 1943, it was a skeleton locked in a cupboard. As a result, I never knew my father. Mother stayed single. She was a wonderful mother.She was going to marry an Irish sapper whom she met at a dance. She married him and discovered three months later that he was a bigamist. After the court case at the Old Bailey, she got three months in prison. My mother said she would never marry again. She had to face magistrates wanting to take me away.Mother worked in the telephone exchange in Headen Hall. We lived in a one-room flat in Leyton E10. I was taken in at Knott's Green Day Nursery daily. I was the youngest child there and was looked after by Matron White and Nurse Jackie.The flat was upstairs, and my mother had to carry the pushchair up and down the stairs. I remember my mother pushing me down Catworth Street. There was a breeze block factory around the corner, and the men who worked there (I was told they were German POWs) would call out to my mother, "lovely baby," or something like that.After 1945, we moved to a downstairs flat further along the street in a 1901 house. The scullery had a butler's sink where we washed ourselves as well as cooked. A zinc bath was brought in every Friday night for a bath in front of the fire. To wash the clothes every Monday, my mother used a rubbing board, Sunlight soap, and Reckitt's Blue.As a toddler, I would go to the larder. Often it was empty except for the brown tin of dried egg. I would dip my finger in it and treat it like sherbet.I remember when we had meat, it was lights, whale blubber, sausages, and Yorkshire pudding as a treat. Occasionally, my mother would sing to me "Because" by Jan Kiepura, whose record she had with a wind-up gramophone. Also, my granny used to sing to me when I was very small, sometimes hymns like "There is a Green Hill Far Away."As a child, I remember being frightened by the bombers that used to scream overhead. I remember hiding in the skirts of my mother and Auntie Daisy, who had her own children as well and cared for me during school holidays.I always remained extremely grateful that my mother brought me up with principles to know right from wrong and taught me a whole range of domestic skills from laying the table, lighting the fire, hanging out washing, darning socks, and more.
Detection of Buckminsterfullerene emission in the diffuse interstellar medium
Creators: name: Berné, O.
name: Cox, N. L. J.
name: Mulas, G.
name: Joblin, C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Emission of fullerenes in their infrared vibrational bands has been detected in space near hot stars. The proposed attribution of the diffuse interstellar bands at 9577 and 9632 Å to electronic transitions of the buckminsterfullerene cation (i.e. C$_{60}^+$ ) was recently supported by new laboratory data, confirming the presence of this species in the diffuse interstellar medium (ISM). In this letter, we present the detection, also in the diffuse ISM, of the 17.4 and 18.9 $μ$m emission bands commonly attributed to vibrational bands of neutral C$_{60}$. According to classical models that compute the charge state of large molecules in space, C$_{60}$ is expected to be mostly neutral in the diffuse ISM. This is in agreement with the abundances of diffuse C$_{60}$ we derive here from observations.
description: Accepted for publication in A&A. v3. including language editing and correction of values for abundances
The Oldest Home Guard and His Relatives
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: George Henry Lyle thought he was the oldest Home Guard. He lived in Hove, where he did his Home Guard duties. He joined the Home Guard in May 1940, where he was guarding the beaches, which were all wired off. Although many of the Home Guard were senior citizens, he believed he was the oldest, being 82 years old when he finished his duties. He finished in August 1943, having to resign at that time because, with the threat of invasion, it was thought he was too old. He was presented with a silver salver in recognition of his work, and someone also drew a caricature of him. These objects were recorded.His niece Penelope, pictured with him in a photograph, was a plotter in the WAAF. She later married a much-decorated Pilot Officer, Ian Arbuthnot Slaughter.A third descendant of George Henry Lyle was Alan Samuel Lyle Smythe MBE. His story and exploits are documented under object 6. Before the war, he worked with the Palestine Police and learned Arabic. In 1940, he was commissioned by the Royal Army Service Corps and transferred to the Intelligence Corps. He served in the Western Desert using the name Caillou as an alias and was captured and imprisoned. He managed to escape and was posted to work with the partisans in Yugoslavia. He was awarded the Military Cross in 1944. He wrote about his wartime experiences in Yugoslavia in "The World is 6 Feet Square." He became a prolific author and actor.
Chalk regional groundwater models and their applicability to site scale processes
Creators: name: Parker, Simon John
Publisher: name: Imperial College London
Year: 2019

description: Chalk is an important aquifer in England. Because of the highly permeable nature of the subsurface, groundwater moves relatively quickly, so that source area for a Chalk stream can change significantly on a seasonal basis. This research looks at both the hydrogeology at site scale and regional scale ground- water models in the Berkshire downs. At the regional scale, two conceptualizations of aquifer transmissivity, a zone-based approach and an interpolated transmissivity field approach, were implemented in the regional groundwater model with multiple parameterizations for each approach. For the river Lambourn, one river within the regional system, model output from both conceptualizations was then used to construct time series of groundwater catchment area based on the piezometric surface. It was found that the ground- water catchment area was highly variable, with values for maximum areas almost double those for minimum areas. Delineation of the groundwater catchment using field data also demonstrated that the area was highly variable. The comparison of model-derived area and field-data derived area resulted in the elimination of some model configurations unable to be eliminated based on groundwater heads and streamflows alone. The variability in the catchment area also challenges the use of a fixed area that is implemented in conceptual models of these catchments. At site scale, an initial approach to make inferences about flow directions in streambed sediments based on piezometric head data was abandoned because the high permeability of such sediments prevents the detection of head differences. Instead, high frequency logging of water temperature and water electrical conductivity were used to build an understanding of the hydrogeology at site scale. Both variables were found to be excellent tracers. It was found, however, that they are best used in conjunction with one another and that high frequency logging is important, as flowpaths can rapidly switch on and off.
Self-Efficacy, Scientific Reasoning, and Learning Achievement in the STEM Project-Based Learning Literature
Creators: name: Seyedh Mahboobeh Jamali
name: Ahmad Nurulazam Md Zain
name: Mohd Ali Samsudin
name: Ebrahim, Nader Ale
Publisher: name: figshare
Year: 2018
Subjects: subject: 130304 Educational Administration, Management and Leadership
subject: FOS: Educational sciences
subject: 130305 Educational Counselling
subject: Education
subject: 130106 Secondary Education
subject: 139999 Education not elsewhere classified
subject: 130210 Physical Education and Development Curriculum and Pedagogy
subject: 130399 Specialist Studies in Education not elsewhere classified
subject: 130313 Teacher Education and Professional Development of Educators

description: The main goal of education is to prepare students for future job opportunities and civic responsibilities, and this is one of the biggest challenges in the 21st century. Science, Technology, Engineering, and Mathematics (STEM) Project-Based Learning (PjBL) prepare students to master their new role as a global citizen with greater responsibilities. This systematic review analyzed 265 papers that are related to the STEM PjBL. The papers were collected from well-known databases such as Web of Science® and SCOPUS by using the quality assessment and relevant criteria. This study inspected the top 48 distinguished papers by covering three dimensions, Search result, Subject, and Research methodology. STEM and PjBL come together, due to the natural overlap between the fields of Science, Technology, Engineering, Mathematics and PjBL. The fully integrated STEM with PjBL can increase the effectiveness of teaching. Nonetheless, this inspection uncovered that previous research has not fully integrated STEM with PjBL. Thus, despite the wealth of existing research, there are still significant opportunities for future research on STEM PjBL in high schools to prepare students for 21st century challenges.
The surprising implications of familial association in disease risk
Creators: name: Valberg, Morten
name: Stensrud, Mats Julius
name: Aalen, Odd O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Background: A wide range of diseases show some degree of clustering in families; family history is therefore an important aspect for clinicians when making risk predictions. Familial aggregation is often quantified in terms of a familial relative risk (FRR), and although at first glance this measure may seem simple and intuitive as an average risk prediction, its implications are not straightforward. Methods: We use two statistical models for the distribution of disease risk in a population: a dichotomous risk model that gives an intuitive understanding of the implication of a given FRR, and a continuous risk model that facilitates a more detailed computation of the inequalities in disease risk. Published estimates of FRRs are used to produce Lorenz curves and Gini indices that quantifies the inequalities in risk for a range of diseases. Results: We demonstrate that even a moderate familial association in disease risk implies a very large difference in risk between individuals in the population. We give examples of diseases for which this is likely to be true, and we further demonstrate the relationship between the point estimates of FRRs and the distribution of risk in the population. Conclusions: The variation in risk for several severe diseases may be larger than the variation in income in many countries. The implications of familial risk estimates should be recognized by epidemiologists and clinicians.
description: 17 pages, 5 figures
Additional file 1 of Correlation of serum delta-like ligand-4 level with the severity of diabetic retinopathy
Creators: name: Zhu, Yan
name: Hu, Jingcheng
name: Du, Xuan
name: Fang, Qionglei
name: Zhou, Yingyi
name: Chen, Ke
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: Additional file 1:
title: ADCO, Cartulaire des Dominicains de Dijon (1286), Cart. 221 (H 53), 170 folios, f. 0273
Creators: name: de la Côte d'Or, Archives départementales
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios, f. 0273, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
Skewness and kurtosis of net baryon-number distributions at small values of the baryon chemical potential
Creators: name: HotQCD Collaboration
name: Bazavov, A.
name: Ding, H. -T.
name: Hegde, P.
name: Kaczmarek, O.
name: Karsch, F.
name: Laermann, E.
name: Mukherjee, Swagato
name: Ohno, H.
name: Petreczky, P.
name: Rinaldi, E.
name: Sandmeyer, H.
name: Schmidt, C.
name: Schroeder, Chris
name: Sharma, S.
name: Soeldner, W.
name: Soltz, R. A.
name: Steinbrecher, P.
name: Vranas, P. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present results for the ratios of mean ($M_B$), variance ($σ_B^2$), skewness ($S_B)$ and kurtosis ($κ_B$) of net baryon-number fluctuations obtained in lattice QCD calculations with a physical light to strange quark mass ratio. Using next-to-leading order Taylor expansions in baryon chemical potential we find that qualitative features of these ratios closely resemble the corresponding experimentally measured cumulants ratios of net proton-number fluctuations for beam energies down to $\sqrt{s_{_{NN}}} \ge 19.6$ GeV. We show that the difference in cumulant ratios for the mean net baryon-number, $M_B/σ_B^2=χ_1^B(T,μ_B)/χ_2^B(T,μ_B)$ and the normalized skewness, $S_Bσ_B=χ_3^B(T,μ_B)/χ_2^B(T,μ_B)$, naturally arises in QCD thermodynamics. Moreover, we establish a close relation between skewness and kurtosis ratios, $S_Bσ_B^3/M_B=χ_3^B(T,μ_B)/χ_1^B(T,μ_B)$ and $κ_Bσ_B^2=χ_4^B(T,μ_B)/χ_2^B(T,μ_B)$, valid at small values of the baryon chemical potential.
description: 14 pages, 13 figures, minor updates, final version
Classification of Matrix Product States with a Local (Gauge) Symmetry
Creators: name: Kull, Ilya
name: Molnar, Andras
name: Zohar, Erez
name: Cirac, J. Ignacio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Matrix Product States (MPS) are a particular type of one dimensional tensor network states, that have been applied to the study of numerous quantum many body problems. One of their key features is the possibility to describe and encode symmetries on the level of a single building block (tensor), and hence they provide a natural playground for the study of symmetric systems. In particular, recent works have proposed to use MPS (and higher dimensional tensor networks) for the study of systems with local symmetry that appear in the context of gauge theories. In this work we classify MPS which exhibit local invariance under arbitrary gauge groups. We study the respective tensors and their structure, revealing known constructions that follow known gauging procedures, as well as different, other types of possible gauge invariant states.
Roads and Rural Development in Sub-Saharan Africa
Creators: name: Berg, Claudia N.
name: CLAUDIA N. BERG
name: Blankespoor, Brian
name: Selod, Harris
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: This paper assesses the relationship between access to markets and land cultivation in sub-Saharan Africa. Using a geo-referenced panel over four decades (1970–2010) during which the road network was significantly improved, we find a modest impact of improved market accessibility on local cropland expansion – especially in places that are exposed to better agricultural production conditions – as well as suggestive evidence of an increase in the local intensity of cultivation. Suggestive evidence of a positive association between improved market accessibility and local GDP growth beyond the impact of cropland expansion could reflect the stimulation of non-agricultural activities.
Functional approximations with Stein's method of exchangeable pairs
Creators: name: Kasprzak, Mikolaj J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60B10, 60F17 (Primary) 60B12, 60J65, 60E05, 60E15 (Secondary)

description: We combine the method of exchangeable pairs with Stein's method for functional approximation. As a result, we give a general linearity condition under which an abstract Gaussian approximation theorem for stochastic processes holds. We apply this approach to estimate the distance of a sum of random variables, chosen from an array according to a random permutation, from a Gaussian mixture process. This result lets us prove a functional combinatorial central limit theorem. We also consider a graph-valued process and bound the speed of convergence of the distribution of its rescaled edge counts to a continuous Gaussian process.
description: will appear in Annales de l'Institut Henri Poincar\'e, Probabilit\'es et Statistiques
Roads and Rural Development in Sub-Saharan Africa
Creators: name: Berg, Claudia N.
name: Blankespoor, Brian
name: Selod, Harris
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: This paper assesses the relationship between access to markets and land cultivation in sub-Saharan Africa. Using a geo-referenced panel over four decades (1970–2010) during which the road network was significantly improved, we find a modest impact of improved market accessibility on local cropland expansion – especially in places that are exposed to better agricultural production conditions – as well as suggestive evidence of an increase in the local intensity of cultivation. Suggestive evidence of a positive association between improved market accessibility and local GDP growth beyond the impact of cropland expansion could reflect the stimulation of non-agricultural activities.
Two stories of E.P. Dovey RM and Charles Spencer Stay
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Charlie Spencer Stay was in the East Surrey Regiment, which was part of the 8th Army. He fought at El Alamein and Monte Cassino after landing at Salerno. As officers were sniper targets and identifiable because they carried Thompson submachine guns, he volunteered to carry his Sergeant's machine gun. The Sergeant died, but he survived. During fighting in the Po Valley, he was shot in the stomach, and he always claimed this was from a Yank's gun, making him a casualty of 'friendly fire'.Eddie Dovey of the Royal Marine MNDBZ was a Beach Marshal who maintained, policed, and took off casualties from beaches. He was involved in four beach assaults, including Salerno, Sicily, and Normandy. He was a Provisional Sergeant for the 4th Commando Brigade in Holland. During the Normandy invasions, Antwerp was used to supply the front line troops. The 42 and 47 Commandos were sent to take Walcheren Island, which was heavily fortified by the Germans. Of the 50 Allied tanks that landed, only two managed to get ashore. However, there were no German tanks in the area, so although only two tanks landed, they had provisions for 50 and were able to operate round the clock, providing cover for the Commandos who were sent in at night for hand-to-hand fighting.He was a Provisional Sergeant at the Bergen op Zoom trials of informers, responsible for bringing witnesses from secure locations. He recalls that many of them were prostitutes.
Quantitative imaging of plasmid DNA in human airway epithelial cells following non-viral gene transfer
Creators: name: Singh, Charanjit
Publisher: name: Imperial College London
Year: 2019

description: The UK CF Gene Therapy Consortium is interested in non-viral gene therapy for cystic fibrosis (CF). To provide insight into the intracellular bottlenecks plasmid DNA (pDNA) encounters on its way to the nuclei of airway epithelial cells, I sought to quantitatively describe the intracellular fate of non-virally transferred pDNA using a clinically relevant human airway epithelial cell air-liquid-interface (ALI) model. Plasmid DNA was tagged with nanogold particles or fluorescent quantum dots (QDots) for use in transmission electron microscopy (TEM) or confocal microscopy studies, respectively. Conjugation of pDNA with either nanogold or QDots did not affect the biological activity. The number of cells showing cytoplasmicaly-localised nanogold-conjugated pDNA increased with increasing transfection time. Interestingly, there was an equal distribution of pDNA in cytoplasm and nuclei of cells transfected for 60 minutes. In the parallel confocal study, QDot-pDNA was visible in nuclei (~12 m below the apical surface) after transfection for only 15 minutes, consistent with our earlier observations. Approximately 8% (n= 349 nuclei from 9 independent ALIs) of nuclei contained QDot-pDNA in ALIs transfected for 15 minutes. I next collected z-stacks of QDot-pDNA-transfected ALIs every 10 minutes up to a maximum of 120 minutes. As expected, some QDot-pDNA remained on the apical surface throughout the transfection period. Importantly, by 60 minutes, there was a time-dependent net movement of the QDot-fluorescence downwards through the epithelium with the number of nuclei containing QDot-pDNA increasing as early as 30 minutes reaching maximum levels of 8.2±4.8% (n=256 nuclei from 7 ALIs). In conclusion, the results from the TEM and confocal studies showed good agreement for the numbers of nuclei containing pDNA at early transfection times (15, 30 and 60 minutes). These data, in a clinically relevant model, should help focus efforts on increasing gene transfer efficiency by finding the strategies to overcome cytoplasmic and nuclear barriers.
RCD: Rapid Close to Deadline Scheduling for datacenter networks
Creators: name: Noormohammadpour, Mohammad
name: Cauligi S. Raghavendra
name: Sriram Rao
name: Madni, Asad M.
Publisher: name: figshare
Year: 2018
Subjects: subject: 80503 Networking and Communications
subject: FOS: Computer and information sciences
subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 100507 Optical Networks and Systems
subject: 100504 Data Communications
subject: 100506 Optical Fibre Communications
subject: 10303 Optimisation
subject: FOS: Mathematics

description: Datacenter-based Cloud Computing services provide a flexible, scalable and yet economical infrastructure to host online services such as multimedia streaming, email and bulk storage. Many such services perform geo-replication to provide necessary quality of service and reliability to users resulting in frequent large inter-datacenter transfers. In order to meet tenant service level agreements (SLAs), these transfers have to be completed prior to a deadline. In addition, WAN resources are quite scarce and costly, meaning they should be fully utilized. Several recently proposed schemes, such as B4 [1], TEMPUS [2], and SWAN [3] have focused on improving the utilization of inter-datacenter transfers through centralized scheduling, however, they fail to provide a mechanism to guarantee that admitted requests meet their deadlines. Also, in a recent study, authors propose Amoeba [4], a system that allows tenants to define deadlines and guarantees that the specified deadlines are met, however, to admit new traffic, the proposed system has to modify the allocation of already admitted transfers. In this paper, we propose Rapid Close to Deadline Scheduling (RCD), a close to deadline traffic allocation technique that is fast and efficient. Through simulations, we show that RCD is up to 15 times faster than Amoeba, provides high link utilization along with deadline guarantees, and is able to make quick decisions on whether a new request can be fully satisfied before its deadline.
A unified approach to $χ^2$ discriminators for searches of gravitational waves from compact binary coalescences
Creators: name: Dhurandhar, Sanjeev
name: Gupta, Anuradha
name: Gadre, Bhooshan
name: Bose, Sukanta
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We describe a general mathematical framework for $χ^2$ discriminators in the context of the compact binary coalescence search. We show that with any $χ^2$ is associated a vector bundle over the signal manifold, that is, the manifold traced out by the signal waveforms in the function space of data segments. The $χ^2$ is then defined as the square of the $L_2$ norm of the data vector projected onto a finite dimensional subspace (the fibre) of the Hilbert space of data trains and orthogonal to the signal waveform - any such fibre leads to a $χ^2$ discriminator and the full vector bundle comprising the subspaces and the base manifold constitute the $χ^2$ discriminator. We show that the $χ^2$ discriminators used so far in the CBC searches correspond to different fiber structures constituting different vector bundles on the same base manifold, namely, the parameter space. The general formulation indicates procedures to formulate new $χ^2$s which could be more effective in discriminating against commonly occurring glitches in the data. It also shows that no $χ^2$ with a reasonable degree of freedom is foolproof. It could also shed light on understanding why the traditional $χ^2$ works so well. As an example, we propose a family of ambiguity $χ^2$ discriminators that is an alternative to the traditional one. Any such ambiguity $χ^2$ makes use of the filtered output of the template bank, thus adding negligible cost to the overall search. We test the performance of ambiguity $χ^2$ on simulated data using spinless TaylorF2 waveforms. We show that the ambiguity $χ^2$ essentially gives a clean separation between glitches and signals. Finally, we investigate the effects of mismatch between signal and templates on the $χ^2$ and also further indicate how the ambiguity $χ^2$ can be generalized to detector networks for coherent observations.
description: 21 pages, 5 figure, abstract is shortened to comply with the arXiv's 1920 characters limitation, v2: accepted for publication in PRD
On the wall velocity dependence of electroweak baryogenesis
Creators: name: Dorsch, Glauber C.
name: Huber, Stephan J.
name: Konstandin, Thomas
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2021
Subjects: subject: 530
subject: approximation: fluid
subject: baryogenesis
subject: electroweak interaction
subject: higher-order
subject: distribution function
subject: fluctuation
subject: velocity dependence

description: We re-evaluate the status of supersonic electroweak baryogenesis using a generalized fluid Ansatz for the non-equilibrium distribution functions. Instead of truncating the expansion to first order in momentum, we allow for higher order terms as well, including up to 21 fluctuations. The collision terms are computed analytically at leading-log accuracy. We also point out inconsistencies in the standard treatments of transport in electroweak baryogenesis, arguing that one cannot do without specifying an Ansatz for the distribution function. We present the first analysis of baryogenesis using the fluid approximation to higher orders. Our results support the recent findings that baryogenesis may indeed be possible even in the presence of supersonic wall velocities.
Study protocol: Asking QUestions about Alcohol in pregnancy (AQUA): a longitudinal cohort study of fetal effects of low to moderate alcohol exposure
Creators: name: Muggli, E
name: O'Leary, C
name: Forster, Della
name: Anderson, P
name: Lewis, S
name: Nagle, C
name: Craig, JM
name: Donath, S
name: Elliott, E
name: Halliday, J
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3215
subject: Reproductive medicine
classificationCode: 321502
subject: Obstetrics and gynaecology
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 3213
subject: Paediatrics

description: Background: Despite extensive research, a direct correlation between low to moderate prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorders has been elusive. Conflicting results are attributed to a lack of accurate and detailed data on PAE and incomplete information on contributing factors. The public health effectiveness of policies recommending complete abstinence from alcohol during pregnancy is challenged by the high frequency of unplanned pregnancies, where many women consumed some alcohol prior to pregnancy recognition. There is a need for research evidence emphasizing timing and dosage of PAE and its effects on child development.Methods/Design: Asking QUestions about Alcohol (AQUA) is a longitudinal cohort aiming to clarify the complex effects of low to moderate PAE using specifically developed and tested questions incorporating dose, pattern and timing of exposure. From 2011, 2146 pregnant women completed a questionnaire at 8-18 weeks of pregnancy. Further prenatal data collection took place via a questionnaire at 26-28 weeks and 35 weeks gestation. Extensive information was obtained on a large number of risk factors to assist in understanding the heterogeneous nature of PAE effects. 1571 women (73%) completed all three pregnancy questionnaires. A biobank of DNA from maternal and infant buccal cells, placental biopsies and cord blood mononuclear cells will be used to examine epigenetic state at birth as well as genetic factors in the mother and child. Participants will be followed up at 12 and 24 months after birth to assess child health and measure infant behavioural and sensory difficulties, as well as family environment and parenting styles. A subgroup of the cohort will have 3D facial photography of their child at 12 months and a comprehensive developmental assessment (Bayley Scales of Infant & Toddler Development, Bayley-III) at two years of age. Discussion: Using detailed, prospective methods of data collection, the AQUA study will comprehensively examine the effects of low to moderate alcohol consumption throughout pregnancy on child health and development, including the role of key mediators and confounders. These data will ultimately contribute to policy review and development, health professional education and information about alcohol consumption for pregnant women in the future.
Charting a path towards a sustainable community of people who work on Research Software
Creators: name: Mosbergen, Rowland
Publisher: name: Zenodo
Year: 2024
Subjects: Training
Skills
Software
Engagement
Infrastructure
Workforce
Strategy
Research Software; RSE;

description: Please join us  to raise awareness within eResearch of the community of people who work on Research Software, the Research Software Engineer Australia New Zealand (RSE-AUNZ) community, and to understand the needs of the community.

This BoF would be of interest to people who:
- Develop research software and are worried about career progression,
- Want to make the research software more visible,
- Streamline and scale research workflows but feel undervalued,
- Balance researcher needs with good software practices, and
- Make research software easier to use.

It would also be useful to those who manage RSEs or who struggle to recruit or maintain RSEs within their project lifecycles, and those who would like to help sustain this community.

Objectives would be to solicit feedback and discussion about the following topics :
- What are the needs of the community and is the RSE-AUNZ meeting those needs?
- What can we do to get more active community participation? Eg. proactively sharing knowledge, joining the steering committee, or asking for help?
- Do we need to apply for grants to help sustain the community, as per the US-RSE?
- How can we ensure greater equity and inclusion within the RSE-AUNZ community to better support and represent all members?
Parity breaking signatures from a Chern-Simons coupling during inflation: the case of non-Gaussian gravitational waves
Creators: name: Bartolo, Nicola
name: Orlando, Giorgio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering high-energy modifications of Einstein gravity during inflation is an interesting issue. We can constrain the strength of the new gravitational terms through observations of inflationary imprints in the actual universe. In this paper we analyze the effects on slow-roll models due to a Chern-Simons term coupled to the inflaton field through a generic coupling function $f(ϕ)$. A well known result is the polarization of primordial gravitational waves (PGW) into left and right eigenstates, as a consequence of parity breaking. In such a scenario the modifications to the power spectrum of PGW are suppressed under the conditions that allow to avoid the production of ghost gravitons at a certain energy scale, the so-called Chern-Simons mass $M_{CS}$. In general it has been recently pointed out that there is very little hope to efficiently constrain chirality of PGW on the basis solely of two-point statistics from future CMB data, even in the most optimistic cases. Thus we search if significant parity breaking signatures can arise at least in the bispectrum statistics. We find that the tensor-tensor-scalar bispectra $\langle γγζ\rangle$ for each polarization state are the only ones that are not suppressed. Their amplitude, setting the level of parity breaking during inflation, is proportional to the second derivative of the coupling function $f(ϕ)$ and they turn out to be maximum in the squeezed limit. We comment on the squeezed-limit consistency relation arising in the case of chiral gravitational waves, and on possible observables to constrain these signatures.
description: 31 pages, 1 figure. V3: references added; typos corrected
Intrinsic two-dimensional state on the pristine surface of tellurium
Creators: name: Li, Pengke
name: Appelbaum, Ian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Using a tight-binding description, we show how the zero-dimensional state bound to the edge of a single one-dimensional helical chain of tellurium atoms evolves into two-dimensional states on the c-axis surface of the three-dimensional trigonal bulk. We give an effective Hamiltonian description of its dispersion in k-space by exploiting confinement to a virtual bilayer, and elaborate on the diminished role of spin-orbit coupling. These previously-unidentified intrinsic gap-penetrating surface bands were neglected in the interpretation of seminal experiments, where two-dimensional transport was otherwise attributed to extrinsic accumulation layers.
Remediation in Canadian medical residency programs: Established and emerging best practices
Creators: name: Shearer, Cindy
name: Bosma, Mark
name: Bergin, Fiona
name: Sargeant, Joan
name: Warren, Andrew
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Background: Policies to guide remediation in postgraduate medical education exist in all Canadian medical schools. This study examines concordance between these policies and processes, and published “best practices” in remediation. Method: We conducted a literature review to identify best practices in the area of remediation. We then reviewed remediation policies from all 13 English medical schools in Canada other than our own and conducted interviews with key informants from each institution. Each policy and interview transcript pair was then reviewed for evidence of pre-defined “best practices.” Team members also noted additional potential policy or process enablers of successful remediation. Results: Most policies and processes aligned with some but not all published best practices. For instance, all participating schools tailored remediation strategies to individual resident needs, and a majority encouraged faculty-student relationships during remediation. Conversely, few required the teaching of goal-setting, strategic planning, self-monitoring, and self-awareness. In addition, we identified avoidance of automatic training extension and the use of an educational review board to support the remediation process as enablers for success. Discussion: Remediation policies and practices in Canada align well with published best practices in this area. Based on key informant opinions, flexibility to avoid training extension and use of an educational review board may also support optimal remediation outcomes.
title: 01_1746
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Spatial Searching for Solar Physics Data
Creators: name: Hourclé, J.A.
name: Spencer, J.L.
Publisher: name: Zenodo
Year: 2013
Subjects: Solar Physics
Spatial Coordinates

description: The Virtual Solar Observatory allows searching across many collections of solar physics data, but does not yet allow a researcher to search based on the location and extent of the observation, other than by selecting general categories such as full disk or off limb. High resolution instruments that observe only a portion of the the solar disk require greater specificity than is currently available. We believe that finer-grained spatial searching will allow for improved access to data from existing instruments such as TRACE, XRT and SOT, and well as from upcoming missions such as ATST and IRIS. Our proposed solution should also help scientists to search on the field of view of full-disk images that are out of the Sun-Earth line, such as STEREO/EUVI and obserations from the upcoming Solar Orbiter and Solar Probe Plus missions. We present our current work on cataloging sub field images for spatial searching so that researchers can more easily search for observations of a given feature of interest, with the intent of soliciting information about researcher's requirements and recommendations for further improvements
Additional file 3 of pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia
Creators: name: Liu, Lin
name: Yao, Wendong
name: Xie, Xiaowei
name: Gao, Jianqing
name: Lu, Xiaoyang
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Additional file 3. Effect of specific endocytosis inhibitor on the uptake of Caco-2 cells.