cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Numerical and experimental investigation of mine exhaust heat recovery systems
Creators: name: Kalantari, Hosein
Publisher: name: University of British Columbia
Year: 2023

description: For underground mining operations in cold climates, such as Canada and Arctic regions, mine intake air heating is a significant energy- and carbon-intensive activity. The high thermal energy demand is commonly met by burning fossil fuels, particularly for mining operations in remote locations with limited grid access. This dependence on fossil fuels not only has an adverse environmental impact, but also incurs high costs. Mining companies are also facing increased pressure from society, investors, and the governments to address their carbon footprint. To overcome this energy–environmental challenge, mining companies are exploring innovative solutions for decarbonizing their operations. One potential solution is the implementation of a mine exhaust heat recovery system for intake air heating. This approach can reduce the high energy reliance of underground mine heating systems. In this study, two different mine exhaust heat recovery systems are proposed - an indirect capture-indirect delivery system and a direct capture-indirect delivery system - and their performances are evaluated using numerical models. Two fully-coupled thermodynamic models are developed to assess the potential economic and environmental implications of the proposed heat recovery systems. Furthermore, to evaluate the direct capture-indirect delivery system, two numerical models with different one-dimensional and three-dimensional approaches are developed to examine the performance of the direct heat capture unit under various design and operational conditions and to determine its ideal configuration for heat recovery applications. An experimental test setup is also designed and constructed to verify the concept of such heat exchanging systems at a lab scale and validate the results of the numerical models. Once the ideal design is identified, the developed thermodynamic code is populated with the operating and climate data from the mining operation being studied. This allows for the calculation of the potential cost savings and carbon emission reduction. The results of the study show that although both proposed heat recovery systems help mitigating the economic-environmental problem of mine intake air heating, the direct heat recovery system is found to be more efficient in terms of both carbon footprint reduction and energy cost savings.
Strengthening the integration of eye care into the health system: methodology for the development of the WHO package of eye care interventions
Creators: name: Keel, Stuart
name: Evans, Jennifer R
name: Block, Sandra
name: Bourne, Rupert
name: Calonge, Margarita
name: Cheng, Ching-Yu
name: Friedman, David S
name: Furtado, João M
name: Khanna, Rohit C
name: Mathenge, Wanjiku
name: Mariotti, Silvio
name: Matoto, Elenoa
name: Müller, Andreas
name: Rabiu, M Mansur
name: Rasengane, Tuwani
name: Zhao, Jialang
name: Wormald, Richard
name: Cieza, Alarcos
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
public health

description: Objective: To describe the rational for, and the methods that will be employed to develop, the WHO package of eye care interventions (PECI). Methods and analysis: The development of the package will be conducted in four steps: (1) selection of eye conditions (for which interventions will be included in the package) based on epidemiological data on the causes of vision impairment and blindness, prevalence estimates of eye conditions and health facility data; (2) identification of interventions and related evidence for the selected eye conditions from clinical practice guidelines and high-quality systematic reviews by a technical working group; (3) expert agreement on the inclusion of eye care interventions in the package and the description of resources required for the provision of the selected interventions; and (4) peer review. The project will be led by the WHO Vision Programme in collaboration with Cochrane Eyes and Vision. A Technical Advisory Group, comprised of public health and clinical experts in the field, will provide technical input throughout all stages of development. Results: After considering the feedback of Technical Advisory Group members and reviewing-related evidence, a final list of eye conditions for which interventions will be included in the package has been collated. Conclusion: The PECI will support Ministries of Health in prioritising, planning, budgeting and integrating eye care interventions into health systems. It is anticipated that the PECI will be available for use in 2021.
Enrollment of research subjects through telemedicine networks in a multicenter acute intracerebral hemorrhage clinical trial: design and methods
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background—Enrollment of subjects in acute stroke trials is often hindered by narrow timeframes, because a large proportion of patients arrive via transfers from outside facilities rather than primary arrival at the enrolling hospital. Rationale—Telemedicine networks have been increasingly used for provision of care for acute stroke patients at facilities outside of major academic centers. Treatment decisions made through telemedicine networks in patients with acute ischemic stroke have been shown to be safe, reliable, and effective. With the expanding use of this technology and the impediments to enrolling subjects into clinical trials, this approach can be applied successfully to the field of clinical research. Methods and conclusions—The Antihypertensive Treatment of Acute Cerebral Hemorrhage II trial is a phase III randomized multicenter trial that has developed a protocol in collaboration with participating sites to implement the use of telemedicine networks for the enrollment of research subjects. The protocol describes the operating procedures and legal and Institutional Review Board perspectives for its implementation
Impact of loss-to-follow-up on cancer survival estimates for small populations: a simulation study using Hospital-Based Cancer Registries in Japan
Creators: name: Okuyama, Ayako
name: Barclay, Matthew
name: Chen, Cong
name: Higashi, Takahiro
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Epidemiology
1506
1692
survival analysis
oncology
simulation
registries
prognosis

description: Objectives: The accuracy of the ascertainment of vital status impacts the validity of cancer survival. This study assesses the potential impact of loss-to-follow-up on survival in Japan, both nationally and in the samples seen at individual hospitals. Design: Simulation study Setting and participants: Data of patients diagnosed in 2007, provided by the Hospital-Based Cancer Registries of 177 hospitals throughout Japan. Primary and secondary outcome measures: We performed simulations for each cancer site, for sample sizes of 100, 1000 and 8000 patients, and for loss-to-follow-up ranging from 1% to 5%. We estimated the average bias and the variation in bias in survival due to loss-to-follow-up. Results: The expected bias was not associated with the sample size (with 5% loss-to-follow-up, about 2.1% for the cohort including all cancers), but a smaller sample size led to more variable bias. Sample sizes of around 100 patients, as may be seen at individual hospitals, had very variable bias: with 5% loss-to-follow-up for all cancers, 25% of samples had a bias of <1.02% and 25% of samples had a bias of > 3.06%. Conclusion: Survival should be interpreted with caution when loss-to-follow-up is a concern, especially for poor-prognosis cancers and for small-area estimates.
Protocol for the use of clozapine in the San Lázaro Specialized Ambulatory Care Center.pdf
Creators: name: Zúñiga Carrasco, Danny Raúl
name: Chávez Ledesma, Claudia Estefanía
name: Palacios Salazar, Jaime Armando
name: Macas González, Doris Verónica
name: Ruiz Álvarez, Mercedes de los Ángeles
name: Jumbo Jima, Diana Rosario
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420309
subject: Health management
classificationCode: 420317
subject: Patient safety

description: Atypical antipsychotic medication clozapine is used to treat schizophrenia that is resistant to therapy.
Due to its link to major adverse effects such neutropenia, agranulocytosis, seizures, myocarditis, and cardiomyopathy, the medication is subject to tight monitoring requirements.
Patients using clozapine have a 2% incidence of neutropenia and a 0.8% incidence of agranulocytosis.

Clozapine will work in about 30–60% of patients with schizophrenia who are resistant to other medications.
Clozapine is often only prescribed to individuals who have tried at least two other antipsychotic medications without success 1,2. (one of which is another atypical antipsychotic).
According to a recent Cochrane analysis, the number needed to treat for clozapine to avoid recurrence was 21 as opposed to the usual antipsychotics.Without receiving antipsychotic medication, almost 80% of schizophrenia patients will experience a relapse.
The Privileged and Useful Migrant: An Evaluation of Changing Policy and Scholarly Approaches Towards High-skilled Migration
Creators: name: Hercog, Mekta
Publisher: name: Zenodo
Year: 2017
Subjects: Skilled international migration
Immigration policies
Migration-development nexus
Integration
Migrant categories

description: The purpose of this paper has been to examine the position of high-skilled migration within the contemporary migration debate in relation to the wider issue of who and what constitutes skilled migration. The paper reviews policy and scholarly approaches towards high-skilled migration within three main strands of research literature: immigration policy analysis, research on migration-development nexus and studies on integration/incorporation in receiving countries. Drawing on the interpretation of trends in these three research strands, this paper presents high-skilled migration as a necessary part of economic competitiveness, as self-help development from below and as a prototype of social mobility. In this sense, highly skilled migrants are portrayed as those who: a) are economically useful and contribute to economic competitiveness; b) benefit development outcomes in their countries of origin; and c) are easily integrated in labor markets and societies at large. As autonomous and economically independent, skilled migrants have privileged treatment and are counted on to boost economies of host societies andof their countries of origin, without posing any issues with their presence. This paper shows how policy and scholarly approaches towards highly skilled migrants determine who will be included in this privileged position. It exposesthe not-so-clear-cut distinction between low-and high-skilled migration and furthersour understanding of the extent to which changing government priorities and ideologies impact international mobility by providing opportunities to move and stay for some, while erecting barriers for others.
ATLAS D1.6: Biologically realistic Langrangian dispersal and connectivity
Creators: name: Fox, Alan
name: Gary, Stefan
name: Biastoch, Arne
name: Cunningham, Stuart
name: Roberts, J Murray
Publisher: name: Zenodo
Year: 2019

description: This presentation discussed modelling of the behaviour of larvae from deep-sea populations at the 4th ATLAS General Assembly.
EHA evaluation of the ESMO—Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for haematological malignancies
Creators: name: Kiesewetter, Barbara
name: Cherny, Nathan I
name: Boissel, Nicolas
name: Cerisoli, Francesco
name: Dafni, Urania
name: De Vries, Elisabeth G E
name: Ghia, Paolo
name: Gökbuget, Nicola
name: González-Calle, Verónica
name: Huntly, Brian
name: Jäger, Ulrich
name: Latino, Nicola Jane
name: Douillard, Jean-Yves
name: Malcovati, Luca
name: Mateos, María-Victoria
name: Ossenkoppele, Gert J
name: Porkka, Kimmo
name: Raderer, Markus
name: Ribera, Josep-Maria
name: Scarfò, Lydia
name: Wester, Ruth
name: Zygoura, Panagiota
name: Sonneveld, Pieter
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
ESMO-MCBS
value frameworks
clinical benefit
haematologic malignancies

description: Objective: Value frameworks in oncology have not been validated for the assessment of treatments in haematological malignancies, but to avoid overlaps and duplications it appears reasonable to build up experience on existing value frameworks, such as the European Society for Medical Oncology—Magnitude of Clinical Benefit Scale (ESMO-MCBS). Methods: Here we present the results of the first feasibility testing of the ESMO-MCBS v1.1 for haematological malignancies based on the grading of 80 contemporary studies for acute leukaemia, chronic leukaemia, lymphoma, myeloma and myelodysplastic syndromes. The aims were (1) to evaluate the scorability of data, (2) to evaluate the reasonableness of the generated grades for clinical benefit using the current version and (3) to identify shortcomings in the ESMO-MCBS v1.1 that require amendments to improve the efficacy and validity of the scale in grading new treatments in the management of haematological malignancies. Results: In general, the ESMO-MCBS v1.1 was found to be widely applicable to studies in haematological malignancies, generating scores that were judged as reasonable by European Hematology Association (EHA) experts. A small number of studies could either not be graded or were not appropriately graded. The reasons, related to the differences between haematological and solid tumour malignancies, are identified and described. Conclusions: Based on the findings of this study, ESMO and EHA are committed to develop a version of the ESMO-MCBS that is validated for haematological malignancies. This development process will incorporate all of the usual stringencies for accountability of reasonableness that have characterised the development of the ESMO-MCBS including field testing, statistical modelling, evaluation for reasonableness and openness to appeal and revision. Applying such a scale will support future public policy decision-making regarding the value of new treatments for haematological malignancies and will provide insights that could be helpful in the design of future clinical trials.
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
Creators: name: Harris, Kate L
name: Kuan, Wei-Li
name: Mason, Sarah L
name: Barker, Roger A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Neurodegeneration
1506

description: Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Huntington’s disease (HD) and as such are a target for therapeutic intervention, especially for the treatment of chorea and some behavioural problems. However, justification for such an intervention is mainly based on case reports and small open label studies and the effects these drugs have on cognition in HD remain unclear. Methods: In this study, we used the Enroll-HD observational database to assess the effects of antidopaminergic medication on motor, psychiatric and cognitive decline, over a 3-year period. We first looked at the annual rate of decline of a group of HD patients taking antidopaminergic medication (n=466) compared with an untreated matched group (n=466). The groups were matched on specified clinical variables using propensity score matching. Next, we studied a separate group of HD patients who were prescribed such medications part way through the study (n=90) and compared their rate of change before and after the drugs were introduced and compared this to a matched control group. Results: We found that HD patients taking antidopaminergic medication had a slower progression in chorea and irritability compared with those not taking such medications. However, this same group of patients also displayed significantly greater rate of decline in a range of cognitive tasks. Conclusion: In conclusion we found that antidopaminergic treatment is associated with improvements in the choreic movements and irritability of HD but worsens cognition. However, further research is required to prospectively investigate this and whether these are causally linked, ideally in a double-blind placebo-controlled trial.
Reporting Shell Egg Movements into Retail Channels in Four West Coast Cities
Creators: name: Pedersen, John R.
name: Mitchell, William L.
name: Pedersen, John R.
name: Mitchell, William L.
Publisher: name: Unknown
Year: 1961
Subjects: subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Research Methods/ Statistical Methods

description: Excerpt from the Summary: The Dairy and Poultry Market News Branch of the Agricultural Marketing Service, USDA, regularly issues valuable and informative reports on current market prices and related marketing information to the poultry industry. These daily and weekly reports are constantly being evaluated and changed to keep up with today's rapidly changing industry. This publication describes how the weekly reports on Movement of Eggs into Retail Channels in Los Angeles, San Francisco, and Seattle were revised and improved and how a new weekly report in Portland-Vancouver was developed. The basic methodology used was developed in an earlier study of the Chicago weekly retail egg movement report. All firms believed to be handling eggs in each of the 4 metropolitan areas were surveyed to evaluate their influence on the market and on existing and future reports. Upon complete analysis of all responding firms in the surveys, a universe of firms was established for each market, from which weekly movements of eggs into retail channels data were collected.
Flow-independent dynamics in aneurysm (FIDA): pressure measurements following partial and complete flow impairment in experimental aneurysm model
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background: There have been growing concerns regarding delayed aneurysm rupture subsequent to the flow-diverting stent deployment. Therefore, more investigations are needed regarding hemodynamic changes secondary to flow-diverting stent deployment. Objective: To study intra-aneurysmal and perianeurysmal pressures after partial and complete flow impairment into the aneurysm. Methods—A silicone model of an 8-mm-sized aneurysm (neck diameter: 5 mm, vessel size: 4 mm) was used. The aneurysm wall was encapsulated and sealed within a 5 ml syringe filled with saline and a pressure sensor guide wire (ComboWire, Volcano Corp.) to detect pressure changes in the perivascular compartment (outer aneurysm wall). A second pressure sensor guide wire was advanced inside the aneurysm sac. Both pressure sensors were continuously measuring pressure inside and outside the aneurysm under pulsatile flow under the following conditions: 1) baseline (reference); 2) a 16 mm by 3.75 mm flow-diverting stent (ev3/Covidien Vascular, Mansfield, MA) deployed in front of the aneurysm; 3) two flow-diverting stents (16 mm by 3.5 mm) were deployed; and 4) a covered stent (4 mm by 16 mm VeriFlex coronary artery stent covered with rubber sheet) was deployed. Results: Mean (±SD) baseline pressures inside and outside the aneurysm were 53.9 (±2.4) mmHg (range 120–40 mmHg) and 15.4 (±0.7) mmHg (range 40–8mmHg), respectively. There was no change in pressure inside and outside the aneurysm after deploying the first and second flow-diverting stents (partial flow impairment) and it remained at 53.9 (±2.7) mmHg and 14.9 (±1) mmHg for the pressure inside and outside the aneurysm, respectively. The pressure recording from outside the aneurysm dropped from 15.4 (±0.7) mmHg to 0.3 (±0.7) mmHg after deploying the covered stent (complete flow impairment). There was no change in pressure inside the aneurysm after deploying the covered stent. Mean (±SD) pressure within the aneurysm was 55.1 (±1.7) mmHg and it remained 54.7 (±1.7) mmHg after covered stent deployment.
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
Creators: name: Kennedy, Nicholas A
name: Jones, Gareth-Rhys
name: Lamb, Christopher A
name: Appleby, Richard
name: Arnott, Ian
name: Beattie, R Mark
name: Bloom, Stuart
name: Brooks, Alenka J
name: Cooney, Rachel
name: Dart, Robin J
name: Edwards, Cathryn
name: Fraser, Aileen
name: Gaya, Daniel R
name: Ghosh, Subrata
name: Greveson, Kay
name: Hansen, Richard
name: Hart, Ailsa
name: Hawthorne, A Barney
name: Hayee, Bu'Hussain
name: Limdi, Jimmy K
name: Murray, Charles D
name: Parkes, Gareth C
name: Parkes, Miles
name: Patel, Kamal
name: Pollok, Richard C
name: Powell, Nick
name: Probert, Chris S
name: Raine, Tim
name: Sebastian, Shaji
name: Selinger, Christian
name: Smith, Philip J
name: Stansfield, Catherine
name: Younge, Lisa
name: Lindsay, James O
name: Irving, Peter M
name: Lees, Charlie W
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Guidelines
1506
2312
crohn's disease
ulcerative colitis
crohn's colitis

description: The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be made to protect our patients and the clinical services they rely on. This is a novel coronavirus; much is unknown as to how it will affect people with IBD. We also lack information about the impact of different immunosuppressive medications. To address this uncertainty, the British Society of Gastroenterology (BSG) COVID-19 IBD Working Group has used the best available data and expert opinion to generate a risk grid that groups patients into highest, moderate and lowest risk categories. This grid allows patients to be instructed to follow the UK government’s advice for shielding, stringent and standard advice regarding social distancing, respectively. Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials.
Costs of postoperative morbidity following paediatric cardiac surgery: observational study
Creators: name: Hudson, Emma
name: Brown, Katherine
name: Pagel, Christina
name: Wray, Jo
name: Barron, David
name: Rodrigues, Warren
name: Stoica, Serban
name: Tibby, Shane M
name: Tsang, Victor
name: Ridout, Deborah
name: Morris, Stephen
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
cardiac surgery
costing
health economics
health service
paediatric surgery

description: Objective: Early mortality rates for paediatric cardiac surgery have fallen due to advancements in care. Alternative indicators of care quality are needed. Postoperative morbidities are of particular interest. However, while health impacts have been reported, associated costs are unknown. Our objective was to calculate the costs of postoperative morbidities following paediatric cardiac surgery. Design: Two methods of data collection were integrated into the main study: (1) case-matched cohort study of children with and without predetermined morbidities; (2) incidence rates of morbidity, measured prospectively. Setting: Five specialist paediatric cardiac surgery centres, accounting for half of UK patients. Patients: Cohort study included 666 children (340 with morbidities). Incidence rates were measured in 3090 consecutive procedures. Methods: Risk-adjusted regression modelling to determine marginal effects of morbidities on per-patient costs. Calculation of costs for hospital providers according to incidence rates. Extrapolation using mandatory audit data to report annual financial burden for the health service. Outcome measures: Impact of postoperative morbidities on per-patient costs, hospital costs and UK health service costs. Results: Seven of the 10 morbidity categories resulted in significant costs, with mean (95% CI) additional costs ranging from £7483 (£3–£17 289) to £66 784 (£40 609–£103 539) per patient. On average all morbidities combined increased hospital costs by 22.3%. Total burden to the UK health service exceeded £21 million each year. Conclusion: Postoperative morbidities are associated with a significant financial burden. Our findings could aid clinical teams and hospital providers to account for costs and contextualise quality improvement initiatives.
Open Source Science Workshop Session 7 - Other Big Data Architectures - ASF
Creators: name: Hogenson, Kirk
Publisher: name: Zenodo
Year: 2022

description: The first part of the presentation goes through several systems in use at ASF are presented: OpenSARlab, Hyp3, Cumulus. OpenSARlab is a Jupyter notebook-based system for prototyping workflows and performing analysis in the cloud next to the data. HyP3 is a system supporting generic processing of high volumes of data in the cloud. Cumulus is an ESDIS system intended to provide a generic setup for ingest of new datasets into the NASA data archives, at DAACs such as ASF. The final part is a discussion of how these systems contribute to the NASA vision of Open Science.
Map #437, Site 5MT10647, Pit Room 228, Nonstructure 241, and Arbitrary Unit 206, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Pit Room 228, Nonstructure 241, and Arbitrary Unit 206, Stratigraphic Profile
Additional file 5 of Rapid and visual detection of milk vetch dwarf virus using recombinase polymerase amplification combined with lateral flow strips
Creators: name: Cao, Yuhao
name: Yan, Dankan
name: Wu, Xinyang
name: Chen, Ziqiang
name: Lai, Yuchao
name: Lv, Lanqing
name: Yan, Fei
name: Chen, Jianping
name: Zheng, Hongying
name: Song, Xuemei
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Additional file 5: Table S2. The Cq values of selected cowpea field plants in MDV detection by qPCR and the corresponding sample information.
Organisational culture and the integrated chronic diseases management model implementation fidelity in South Africa: a cross-sectional study
Creators: name: Lebina, Limakatso
name: Kawonga, Mary
name: Alaba, Olufunke
name: Khamisa, Natasha
name: Otwombe, Kennedy
name: Oni, Tolu
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Health services research
1506
1704
health services administration & management
health policy
human resource management
quality in health care

description: Funder: South African Medical Research Council; FundRef: http://dx.doi.org/10.13039/501100001322; Grant(s): Self-Initiated Research Grant number: 494184
description: Objective: To assess whether organisational culture influences the fidelity of implementation of the Integrated Chronic Disease Management (ICDM) model at primary healthcare (PHC) clinics. Design: A cross-sectional study. Setting: The ICDM model was introduced in South African clinics to strengthen delivery of care and improve clinical outcomes for patients with chronic conditions, but the determinants of its implementation have not been assessed. Participants: The abbreviated Denison organisational culture (DOC) survey tool was administered to 90 staff members to assess three cultural traits: involvement, consistency and adaptability of six PHC clinics in Dr. Kenneth Kaunda and West Rand (WR) health districts. Primary and secondary outcome measures: Each cultural trait has three indices with five items, giving a total of 45 items. The items were scored on a Likert scale ranging from one (strongly disagree) to five (strongly agree), and mean scores were calculated for each item, cultural traits and indices. Descriptive statistics were used to describe participants and clinics, and Pearson correlation coefficient to asses association between fidelity and culture. Results: Participants’ mean age was 38.8 (SD=10.35) years, and 54.4% (49/90) were nurses. The overall mean score for the DOC was 3.63 (SD=0.58). The involvement (team orientation, empowerment and capability development) cultural trait had the highest (3.71; SD=0.72) mean score, followed by adaptability (external focus) (3.62; SD=0.56) and consistency (3.56; SD=0.63). There were no statistically significant differences in cultural scores between PHC clinics. However, culture scores for all three traits were significantly higher in WR (involvement 3.39 vs 3.84, p=0.011; adaptability 3.40 vs 3.73, p=0.007; consistency 3.34 vs 3.68, p=0.034). Conclusion: Leadership intervention is required to purposefully enhance adaptability and consistency cultural traits of clinics to enhance the ICDM model’s principles of coordinated, integrated, patient-centred care.
Expanding Eliot's realist aesthetic : embodied realist strategies in George Eliot's The lifted veil
Creators: name: Shonoda, Mary-Anne
Publisher: name: University of British Columbia
Year: 2023

description: Scholarship on George Eliot’s The Lifted Veil (1859), initially interpreted this novella as an anomaly in her realist oeuvre. More recently, scholars have responded to the text through critical frameworks that emphasise the novella’s realist aspects, particularly its engagement with Victorian science. In this thesis, I draw on research from cognitive psychology and cognitive linguistic studies to show Eliot uses what I call, embodied realist strategies—strategies that require readers to make sense of textual information by drawing on stored, embodied experience—to reveal new ways that the novella aligns with Eliot’s realist aesthetic and ultimately expands our understanding of it. In Chapter One, I situate The Lifted Veil within key visual and critical contexts and outline the three embodied realist strategies that I use to analyse her novella: multimodal integration, the synaesthetic sensorium and sympathy-via-sensory-analogue. Chapter Two applies these embodied realist strategies to analyse The Lifted Veil, revealing how the novella renders the extraordinary experiences of its protagonist palpably real and intimately knowable. In doing so, I demonstrate how Eliot grounds her narrative in ordinary, embodied human experience and ultimately provides a means for readers to legitimately sympathise with the novella’s protagonist. This approach thus responds to claims that Eliot’s ethics of sympathy lead only to projection or disguised egoism. Finally, in the coda to this thesis, I briefly outline how embodied realist strategies may be productively applied to novels already recognised as realist, such as Eliot’s Middlemarch, to explain realist effects not yet considered by Eliot scholarship.
A Journey Through the Cosmos.pdf
Creators: name: Green, Diane
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 360299
subject: Creative and professional writing not elsewhere classified

description: "What is Poetry?" provides a compendium that providesaccessibility, and easy discovery making it easier for people to discover new poems and poets they may not have encountered otherwise. This can be especially helpful for those who are new to poetry or who are looking for specific themes or styles.Having well known poems readily available can encourage more frequent engagement with poetry. Whether it's during a brief coffee break or while waiting in line, a quick compendium allows for instant immersion in the world of verse.It brings education, appreciation and exposure to diverse voices. A well-curated compendium can offer a glimpse into various historical periods, cultures, and perspectives, broadening the reader's understanding and appreciation of poetry.A quick reference guide can be invaluable for students or casual readers seeking to learn about different poetic forms, styles, and techniques.Inspiration: Reading a variety of poems can spark creativity and inspire individuals to write their own poetry.Poetry's evocative language and imagery can provide a calming and meditative experience, reducing stress and promoting relaxation.Emotional connection: Poems can evoke a range of emotions, allowing readers to connect with their own feelings and experiences in a meaningful way. Engaging with poetry can challenge perspectives, stimulate critical thinking, and encourage personal reflection and growth.
Joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals
Creators: name: Ekelund, Ulf
name: Tarp, Jakob
name: Fagerland, Morten W
name: Johannessen, Jostein Steene
name: Hansen, Bjørge H
name: Jefferis, Barbara J
name: Whincup, Peter H
name: Diaz, Keith M
name: Hooker, Steven
name: Howard, Virginia J
name: Chernofsky, Ariel
name: Larson, Martin G
name: Spartano, Nicole
name: Vasan, Ramachandran S
name: Dohrn, Ing-Mari
name: Hagströmer, Maria
name: Edwardson, Charlotte
name: Yates, Thomas
name: Shiroma, Eric J
name: Dempsey, Paddy
name: Wijndaele, Katrien
name: Anderssen, Sigmund A
name: Lee, I-Min
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
2314
accelerometer
sedentary
meta-analysis
death

description: Funder: National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care East Midlands
description: Funder: National Institute on Aging
description: Funder: Stockholms Läns Landsting; FundRef: http://dx.doi.org/10.13039/501100004348
description: Funder: Norwegian Directorate for Public Health
description: Funder: Centrum for Idrottsforskning; FundRef: http://dx.doi.org/10.13039/501100005350
description: Funder: The Coca-Cola Company
description: Objectives: To examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality. Methods: We conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis. Results: Across cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively. Conclusion: Higher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.
The Conservation Reserve Program in Georgia: Its Effects in the Piedmont and Coastal Plain
Creators: name: McArthur, W. C.
name: McArthur, W. C.
Publisher: name: Unknown
Year: 1961
Subjects: Agricultural and Food Policy
Crop Production/Industries
Farm Management
Labor and Human Capital
Land Economics/Use
Livestock Production/Industries
Resource /Energy Economics and Policy

description: Excerpt from the report: The main objectives of the study were to determine: (1) How farmers who participate in the program differ from non-participants with respect to such factors as age, residence of operators, off-farm employment, farm organization, and resource use; and (2) the effects of the program on crop and livestock production and on use of land, labor, machinery, buildings, and other resources.
Sotrovimab: First Approval
Creators: name: Heo, Young-A
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Young-A Heo is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable Additional information about this Adis Drug Review can be found here Abstract
Sotrovimab (Xevudy®) is a recombinant monoclonal antibody targeted against the severe acute respiratory syndrome coronavirus 2. It is being developed by Vir Biotechnology in collaboration with GlaxoSmithKline for the treatment of coronavirus disease 2019 (COVID-19). Sotrovimab received its first emergency use authorization in May 2021 for the treatment of COVID-19 in the USA, with interim, emergency or conditional authorizations subsequently granted in several other countries. In December 2021, sotrovimab received its first full approval in the EU for use in adolescents (aged ≥ 12 years and weighing ≥ 40 kg) and adults with COVID-19 who do not require oxygen supplementation and who are at high risk of progressing to severe COVID-19. This article summarizes the milestones in the development of sotrovimab leading to this first approval.

© Springer Nature Switzerland AG 2022
Body mass index, prudent diet score and social class across three generations: evidence from the Hertfordshire Intergenerational Study
Creators: name: Carter, Sarah
name: Parsons, Camille
name: Ward, Kate
name: Clynes, Michael
name: Dennison, Elaine M
name: Cooper, Cyrus
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Original research
1506
dietary patterns
microbiome
musculo-skeletal health
nutrient deficiencies

description: Background: Studies describing body mass index (BMI) and prudent diet score have reported that they are associated between parents and children. The Hertfordshire Intergenerational Study, which contains BMI, diet and social class information across three generations, provides an opportunity to consider the influence of grandparental and parental BMI and prudent diet score across multiple generations, and the influence of grandparental and parental social class on child BMI. Methods: Linear regressions examining the tracking of adult BMI and prudent diet score across three generations (grandparent (F0), parent (F1) and child (F2)) were run from parent to child and from grandparent to grandchild. Linear mixed models investigated the influence of F0 and F1 BMI or prudent diet score on F2 BMI and prudent diet score. Linear regressions were run to determine whether social class and prudent diet score of parents and grandparents influenced the BMI of children and grandchildren. Results: BMI was significantly associated across each generational pair and from F0 to F1 in multilevel models. Prudent diet score was significantly positively associated between grandparents and grandchildren. Lower grandparental and parental social class had a significantly positive association with F2 BMI (F0 low social class: b=1.188 kg/m2, 95% CI 0.060 to 2.315, p=0.039; F1 middle social class: b=2.477 kg/m2, 95% CI 0.726 to 4.227, p=0.006). Conclusion: Adult BMI tracks across generations of the Hertfordshire Intergenerational Study, and child BMI is associated with parental and grandparental social class. The results presented here add to literature supporting behavioural and social factors in the transmission of BMI across generations.
Examining climate change frames in education, policy, and science
Creators: name: Pham, Chi
Publisher: name: University of British Columbia
Year: 2023

description: Globally, the Intergovernmental Panel on Climate Change (IPCC) and the United Nations Framework Convention on Climate Change (UNFCCC) are two influential establishments that work on synthesizing scientific knowledge and fostering policy action on climate change, respectively. In parallel to these, the United Nations Educational Scientific and Cultural Organization (UNESCO) has become a key player in setting and driving the global agenda for how the education sector can respond to the climate crisis. This study examines how the three international organizations communicate their messages and appeal to their intended stakeholders through the adoption of frames. Frames establish specific lens through which problems, causes, solutions, and moral evaluations of phenomena are defined and made salient to the audience. Through a frame analysis of publications, reports, and documents released by UNESCO, the UNFCCC, and the IPCC, the study seeks to understand how communication about climate change is shaped by some of the most eminent organizations in climate change education, policy, and science at the global level. I spotlight UNESCO’s Climate Change Education initiative and its corresponding publications, as well as major accords and reports by the UNFCCC and IPCC respectively. The findings include a comprehensive comparison among the organizations and their overlaps and gaps in climate change frames. The study further advances discussions on the use of frame theory in informing and strengthening policymaking in the context of the climate crisis. I also propose a framework in which frames may serve as an effective tool for advancing policy agendas of climate change.
title: The Harz Mountains (Germany) – Cadomia meets Avalonia and Baltica: U-Pb ages of detrital and magmatic zircon as a key for the decoding of Pangea´s central suture
Creators: name: Linnemann, Ulf
name: Zweig, Maren
name: Zieger-Hofmann, Mandy
name: Vietor, Tim
name: Zieger, Johannes
name: Gärtner, Jessica
name: Gärtner, Andreas
name: Mende, Katja
name: Krause, Rita
name: Knolle, Friedhart
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The nature of Pangea´s internal suture in the Central European Variscides is evaluated on the example of the Harz Mountains (Germany). U-Pb ages of detrital (n = 2273) and magmatic zircon grains (n = 170) were obtained by LA ICP-MS for provenance studies and absolute age dating. Provenance studies point to a docking of East Avalonia onto southern Baltica at c. 430 Ma and to a closure of the Rheic Ocean at c. 430-420 Ma. In the aftermath, the re-opening of a narrow Rhenish Seaway happened in mid-Devonian time. Devonian aged sedimentary rocks of the Harz Mountains were formed at the north-western (Rheno-Hercynian) and on the south-eastern (Saxo-Thuringian) margin of the Rhenish seaway. Deposits formed on the Rheno-Hercynian margin display sedimentary supply from southern Baltica, while most East Avalonian sources were buried and not available for erosion. Siliciclastic shelf deposits of Saxo-Thuringia were derived from Cadomia and its West African hinterland. Provenance studies and spatial arrangement of the tectonostratigraphic units in the Harz Mountains allow to reconstruct the style of obduction of the Harz Mountains onto the southeastern margin of East Avalonia (Rheno-Hercynian Zone). As a result of the closure of the Rhenish Seaway and the collision with the Mid-German Crystalline Zone, the Harz Mountains show a building plan strongly dominated by thin skinned tectonics. Our new data favour a two-plate model for the origin of Pangea´s internal suture in the Central European Variscides, but a re-opening of a narrow oceanic seaway is necessary after closure of the Rheic Ocean.
Specialty COPD care during COVID-19: patient and clinician perspectives on remote delivery
Creators: name: Wu, Frances
name: Burt, Jenni
name: Chowdhury, Teena
name: Fitzpatrick, Raymond
name: Martin, Graham
name: Van Der Scheer, Jan W
name: Hurst, John R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Chronic obstructive pulmonary disease
1506
2474
2215
COPD exacerbations
inhaler devices
long-term oxygen therapy (LTOT)

description: Funder: The Health Foundation
description: Introduction: The COVID-19 pandemic has impacted specialty chronic obstructive pulmonary disease (COPD) care. We examined the degree to which care has moved to remote approaches, eliciting clinician and patient perspectives on what is appropriate for ongoing remote delivery. Methods: Using an online research platform, we conducted a survey and consensus-building process involving clinicians and patients with COPD. Results: Fifty-five clinicians and 19 patients responded. The majority of clinicians felt able to assess symptom severity (n=52, 95%), reinforce smoking cessation (n=46, 84%) and signpost to other healthcare resources (n=44, 80%). Patients reported that assessing COPD severity and starting new medications were being addressed through remote care. Forty-three and 31 respondents participated in the first and second consensus-building rounds, respectively. When asked to rate the appropriateness of using remote delivery for specific care activities, respondents reached consensus on 5 of 14 items: collecting information about COPD and overall health status (77%), providing COPD education and developing a self-management plan (74%), reinforcing smoking cessation (81%), deciding whether patients should seek in-person care (72%) and initiating a rescue pack (76%). Conclusion: Adoption of remote care delivery appears high, with many care activities partially or completely delivered remotely. Our work identifies strengths and limitations of remote care delivery.
Rana fusca var. longipes Linnaeus 1758
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Ranidae
Rana

description: Rana fusca (var. longipes).
Oberweiler (Baden) v. F M.
Dieses mir durch gewaltige Sprünge auffallende Tier ﬁeng ieh in der Nähe von Badenweiler und glaubte beim ersten Anblick den Springfroech (R. agiiis Th.) gefunden zu haben. Die nähere Besichtigung ergab eine besonders langbeinige Form der R. fuses acutirostris Fatio. Die tibia ist genau so lang wie die vordere Extremität von der Achselhöhle bis zur Spitze des dritten Fingers, und die Fersen reichen bei Anlegung beider Beine an den platten Körper um etwa 2 mm. über die Sehnauzenspitze hinaus. Der Körper misst von Schnauzenspitze zu After 60 mm., die hintere Extremität von After zur Spitze der vierten Zehe 97 mm. Der erste Finger beträchtlich länger als der zweite, das Trommelfell ²/₃ des Anges. Schnauze langgestreckt, der der R. esculente gleichend. — Höcker an der Basis der ersten Zehe wohlentwickelt, länglich; keine Spur eines solchen an der Basis der vierten Zehe. —— Bauch ungeﬂeckt, die rluukeln Querbarren über femur und tibia sehr schräg gestellt. — Gelenkhöcker, Anordnung der Vomerzahngruppen und Vonıerzähne etc. wie bei R. fusca.
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 670, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591