cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fifteen Genetic Loci Associated with the Electrocardiographic P Wave
Creators: name: Whitsel, E.A.
name: Meitinger, T.
name: Schnabel, R.B.
name: Teumer, A.
name: Isaacs, A.
name: Müller-Nurasyid, M.
name: Tinker, L.F.
name: Waldenberger, M.
name: Christophersen, I.E.
name: Limacher, M.C.
name: Psaty, B.M.
name: Smith, J.D.
name: Hofman, A.
name: Krijthe, B.P.
name: Reiner, A.P.
name: Soliman, E.Z.
name: Chung, M.K.
name: Bis, J.C.
name: Arking, D.E.
name: Petersmann, A.
name: Kors, J.A.
name: Peters, A.
name: Avery, C.L.
name: Duan, Q.
name: Benjamin, E.J.
name: Völker, U.
name: Sotoodehnia, N.
name: Barnard, J.
name: Lubitz, S.A.
name: Buzkova, P.
name: Dörr, M.
name: Van Duijn, C.
name: Van Wagoner, D.R.
name: Li, Y.
name: Alonso, A.
name: Heckbert, S.R.
name: Stricker, B.H.
name: North, K.E.
name: Yin, X.
name: Magnani, J.W.
name: Felix, S.B.
name: Müller, C.
name: Wilhelmsen, K.C.
name: Zhang, Z.-M.
name: Kerr, K.F.
name: Sinner, M.F.
name: Niemeijer, M.N.
name: Weng, L.-C.
name: Ellinor, P.T.
name: Uitterlinden, A.
name: Rotter, J.I.
name: Kääb, S.
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies. Methods and Results - We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using inverse-variance weighting. In meta-analyses of P-wave duration, we identified 6 significant (P<5×10-8) novel loci and replicated a prior association with SCN10A. We identified 3 loci at SCN5A, TBX5, and CAV1/CAV2 that were jointly associated with the PR interval, PR segment, and P-wave duration. We identified 6 novel loci in meta-analysis of P-wave terminal force. Four of the identified genetic loci were significantly associated with gene expression in 329 left atrial samples. Finally, we observed that some of the loci associated with the P wave were linked to overall atrial conduction, whereas others identified distinct phases of atrial conduction. Conclusions - We have identified 6 novel genetic loci associated with P-wave duration and 6 novel loci associated with P-wave terminal force. Future studies of these loci may aid in identifying new targets for drugs that may modify atrial conduction or treat atrial arrhythmias.
Supporting Information from An ecophysiological model of plant-pest interactions: the role of nutrient and water availability
Creators: name: Zaffaroni, Marta
name: Cunniffe, Nik J.
name: Bevacqua, Daniele
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Environmental Science
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Including: Available data, Model initialization and off-line calibration, and Model calibration.
Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts
Creators: name: Laurie, C.C.
name: Raffield, L.M.
name: Soliman, E.Z.
name: Jain, D.
name: Guo, X.
name: Lange, L.A.
name: Reiner, A.P.
name: Peters, U.
name: Rotter, J.I.
name: Jackson, R.D.
name: Browning, S.R.
name: Kooperberg, C.
name: Perez, M.V.
name: Sotoodehnia, N.
name: Lin, H.J.
name: Browning, B.L.
name: Sofer, T.
name: Hohensee, C.
name: Li, Y.
name: Méndez-Giráldez, R.
name: Yao, J.
name: Conomos, M.P.
name: Kerr, K.F.
name: Wilson, J.G.
name: Whitsel, E.A.
name: Zhang, Z.-M.
name: Taylor, K.D.
name: Thornton, T.A.
name: Zhang, Q.S.
name: Heckbert, S.R.
name: Gogarten, S.M.
name: Avery, C.L.
Publisher: name: Elsevier B.V.
Year: 2017

description: Background Although time–domain measures of heart rate variability (HRV) are used to estimate cardiac autonomic tone and disease risk in multiethnic populations, the genetic epidemiology of HRV in Hispanics/Latinos has not been characterized. Objective The purpose of this study was to conduct a genome-wide association study of heart rate (HR) and its variability in the Hispanic Community Health Study/Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Women's Health Initiative Hispanic SNP-Health Association Resource project (n = 13,767). Methods We estimated HR (bpm), standard deviation of normal-to-normal interbeat intervals (SDNN, ms), and root mean squared difference in successive, normal-to-normal interbeat intervals (RMSSD, ms) from resting, standard 12-lead ECGs. We estimated associations between each phenotype and 17 million genotyped or imputed single nucleotide polymorphisms (SNPs), accounting for relatedness and adjusting for age, sex, study site, and ancestry. Cohort-specific estimates were combined using fixed-effects, inverse-variance meta-analysis. We investigated replication for select SNPs exceeding genome-wide (P <5 × 10–8) or suggestive (P <10–6) significance thresholds. Results Two genome-wide significant SNPs replicated in a European ancestry cohort, 1 one for RMSSD (rs4963772; chromosome 12) and another for SDNN (rs12982903; chromosome 19). A suggestive SNP for HR (rs236352; chromosome 6) replicated in an African-American cohort. Functional annotation of replicated SNPs in cardiac and neuronal tissues identified potentially causal variants and mechanisms. Conclusion This first genome-wide association study of HRV and HR in Hispanics/Latinos underscores the potential for even modestly sized samples of non-European ancestry to inform the genetic epidemiology of complex traits.
A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL
Creators: name: Graff, M.
name: Heller, R.
name: Reiner, A.P.
name: North, K.E.
name: Bogomolov, M.
name: Benjamini, Y.
name: Thornton, T.A.
name: Laurie, C.C.
name: Rice, K.
name: Avery, C.L.
name: Kerr, K.F.
name: Sofer, T.
Publisher: name: Wiley-Liss Inc.
Year: 2017

description: In genome-wide association studies (GWAS), “generalization” is the replication of genotype-phenotype association in a population with different ancestry than the population in which it was first identified. Current practices for declaring generalizations rely on testing associations while controlling the family-wise error rate (FWER) in the discovery study, then separately controlling error measures in the follow-up study. This approach does not guarantee control over the FWER or false discovery rate (FDR) of the generalization null hypotheses. It also fails to leverage the two-stage design to increase power for detecting generalized associations. We provide a formal statistical framework for quantifying the evidence of generalization that accounts for the (in)consistency between the directions of associations in the discovery and follow-up studies. We develop the directional generalization FWER (FWERg) and FDR (FDRg) controlling r-values, which are used to declare associations as generalized. This framework extends to generalization testing when applied to a published list of Single Nucleotide Polymorphism-(SNP)-trait associations. Our methods control FWERg or FDRg under various SNP selection rules based on P-values in the discovery study. We find that it is often beneficial to use a more lenient P-value threshold than the genome-wide significance threshold. In a GWAS of total cholesterol in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), when testing all SNPs with P-values < 5 × 10-8 (15 genomic regions) for generalization in a large GWAS of whites, we generalized SNPs from 15 regions. But when testing all SNPs with P-values < 6.6 × 10-5 (89 regions), we generalized SNPs from 27 regions.
Discrete Signal Processing on Graphs: Sampling Theory
Creators: name: Chen, Siheng
name: Varma, Rohan
name: Sandryhaila, Aliaksei
name: Kovačević, Jelena
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: We propose a sampling theory for signals that are supported on either directed or undirected graphs. The theory follows the same paradigm as classical sampling theory. We show that perfect recovery is possible for graph signals bandlimited under the graph Fourier transform. The sampled signal coefficients form a new graph signal, whose corresponding graph structure preserves the first-order difference of the original graph signal. For general graphs, an optimal sampling operator based on experimentally designed sampling is proposed to guarantee perfect recovery and robustness to noise; for graphs whose graph Fourier transforms are frames with maximal robustness to erasures as well as for Erdős-Rényi graphs, random sampling leads to perfect recovery with high probability. We further establish the connection to the sampling theory of finite discrete-time signal processing and previous work on signal recovery on graphs. To handle full-band graph signals, we propose a graph filter bank based on sampling theory on graphs. Finally, we apply the proposed sampling theory to semi-supervised classification on online blogs and digit images, where we achieve similar or better performance with fewer labeled samples compared to previous work.
description: To appear in IEEE T-SP
Food impact assessment on exhaled breath volatile organic compounds using a portable membrane inlet mass spectrometer
Creators: name: Jakšić, Milena
name: Mihajlović, Andrea
name: Vujić, Djordje
name: Brkić, Boris
Publisher: name: Zenodo
Year: 2022

description: Introduction: It is well known that exhaled breath composition is instant reflection of the organism since volatile metabolites tend to move from the blood into the air in the lungs. Therefore, breatholomics is becoming very popular as а new non-invasive screening diagnostic tool. This research brings a portable, low-cost screening sensor prototype based on membrane-inlet mass spectrometry (MIMS) for food impact assessment, by tracking changes of volatile organic compounds (VOCs) in exhaled breath. Analytes of interest are breath VOCs that are related to the metabolism of the main food constituents. Methods: 150 exhaled breath samples were collected from 50 adult healthy volunteers with informed consents and ethical approval completed (Approval No. 2021-01-3/70-1). Each participant provided a sample before meal (after 12h fasting period), 60 min and 120 min after the meal. All samples were analyzed using MIMS system for selected VOC mass fragments – m/z 58 for acetone, m/z 42 for n-pentane, m/z 45 for ethanol and m/z 67 for isoprene. Sample introduction was done using PDMS sheet membrane probe heated at 70◦C. VOC gas standards were prepared by static dilution technique and used for quantification. Results: Significant change (more than 10% increment or decrement) upon meal consumption was observed in ~85% of participants for acetone and ethanol, ~70% for n-pentane and ~50% for isoprene. Changes in selected analytes’ signals were compared for 60min and 120min after the meal, and greater change was observed 120 min after the meal for all analytes, except for ethanol. Obtained mean values for acetone, ethanol, n-pentane, and isoprene respectively were: 809 ppb, 488 ppb, 30 ppb and 70 ppb in samples before meal, 875 ppb, 532 ppb, 29 ppb and 68 ppb in samples collected 60 min after the meal and 559 ppb, 474 ppb, 27 ppb and 66 ppb in samples collected 120 min after the meal. According to the results obtained, it can be said that MIMS system used in this study could be employed in food impact assessment by analyzing breath VOCs. It has been established that major food impact can be monitored 120 min after the meal for analyzed mass fragments. Additionally, obtained mean values were ranked in expected order of magnitude and not surprisingly – the most significant food impact was observed for acetone. Further research will include more participants with different nutritional and health backgrounds, which will expand the knowledge in this area. Novel Aspect: Employment of portable MIMS system in food impact assessment offers a great advantage for possible preventive screening analyses that would provide an alert for nutritional imbalances.
The environmental epidemiology of atrial Arrhythmogenesis
Creators: name: Whitsel, E.A.
name: Avery, C.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Atrial fibrillation (AF) is the most common cardiac arrhythmia seen in clinical practice, and makes an important contribution to cardiovascular disease (CVD) and all-cause mortality. The focus of AF research has recently shifted, from concentrating on treatments and complications, to the evaluation of putative risk factors including ambient air pollution. Although the present study pertains specifically to AF, much of its content is drawn from, and therefore is applicable to, the study of other arrhythmias, the conduct of which is confronted by many of the same challenges. Meeting these challenges involves recognising the collective importance of 1. large, ethnically and geographically diverse, clinically well-characterised populations; 2. methods for reducing uncertainty in outcome ascertainment, distinguishing effects of pervasive environmental exposures and improving their estimation; 3. approaches to evaluation of susceptibility; and 4. strategies for informing regulatory policies designed to help control population-level risks for CVD.
Xenopus: Experimental access to cardiovascular development, regeneration discovery, and cardiovascular heart-defect modeling
Creators: name: Conlon, F.L.
name: Hoppler, S.
Publisher: name: Cold Spring Harbor Laboratory Press
Year: 2020

description: Xenopus has been used to study a wide array of developmental processes, benefiting from vast quantities of relatively large, externally developing eggs. Xenopus is particularly amenable to examining the cardiac system because many of the developmental processes and genes involved in cardiac specification, differentiation, and growth are conserved between Xenopus and human and have been characterized in detail. Furthermore, compared with other higher vertebrate models, Xenopus embryos can survive longer without a properly functioning heart or circulatory system, enabling investigation of later consequences of early embryological manipulations. This biology is complemented by experimental technology, such as embryonic explants to study the heart, microinjection of overexpression constructs, and, most recently, the generation of genetic mutations through gene-editing technologies. Recent investigations highlight Xenopus as a powerful experimental system for studying injury/repair and regeneration and for congenital heart disease (CHD) modeling, which reinforces why this model system remains ideal for studying heart development.
Stability and Anomalous Compressibility of Bose Gases Near Resonance: The scale-dependent interactions and thermal effects
Creators: name: Jiang, Shao-Jian
name: Zhou, Fei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The stability of Bose gases near resonance has been a puzzling problem in recent years. In this Letter, we demonstrate that in addition to generating thermal pressure, thermal atoms enhance the repulsiveness of the scale-dependent interactions between condensed atoms due to renormalization effect and further stabilize the Bose gases. Consequently, we find that, as a precursor of instability, the compressibility develops an anomalous structure as a function of scattering length and is drastically reduced compared with the mean-field value. Furthermore, the density profile of a Bose gas in a harmonic trap is found to develop a flat top near the center. This is due to the anomalous behavior of compressibility and can be a potential smoking gun for probing such an effect.
description: 5 pages, 3 figures
Balance Sheet of the Farming Sector, 1975
Creators: name: Evans, Carson D.
name: Allen, Philp T.
name: Simunek, Richard W.
name: Hottel, James B.
name: Evans, Carson D.
name: Allen, Philp T.
name: Simunek, Richard W.
name: Hottel, James B.
Publisher: name: Unknown
Year: 1975
Subjects: Financial Economics
Production Economics

description: The January 1, 1975, value of farm assets totaled $520.2 billion. Debt amounted to $81.8 billion, leaving proprietors’ equity of $438.4 billion. The total figures were records but increases were not; the increase in debt slowed somewhat and the gains in assets and equity were half what they were during 1973. The value of farm real estate showed a $46.1 billion increase, machinery and motor vehicles added another $11.6 billion, and other assets experienced modest increases, but a drop in the value of livestock of $17.8 billion reduced the gain in all assets to $44.3 billion. Total farm debt rose $7.7 billion during 1974; real estate debt increased about 12 percent in 1974 and nonreal estate debt about 10 percent. Revisions in estimates of nonreal estate debt owed to merchants, dealers, and other miscellaneous lenders substantially lowered the farm debt-to-asset ratio. On January 1,1975, the debt-to-asset ratio was 15.7 percent, about the same as a year earlier but down considerably from 16.9 percent on January 1,1973. Substantially higher farm incomes in 1973 and later probably helped reduce farmers' demand for borrowed money. Returns to equity in farm production assets during 1974 was 5.8 percent, substantially higher than the average since 1960 but sharply below the 10.5 percent for 1973, as increased production expenses outran gains in farm income. The Balance Sheet of the Farming Sector now includes data for Alaska and Hawaii beginning with 1960; formerly estimates were available for only the 48 contiguous States through 1968.
Balance Sheet of the Farming Sector, 1976, Supplement 1 to AIB No. 403
Creators: name: Evans, Carson D.
name: Simunek, Richard W.
name: Evans, Carson D.
name: Simunek, Richard W.
Publisher: name: Unknown
Year: 1977
Subjects: Financial Economics
Production Economics

description: Farm assets were valued at $634.3 billion on January 1,1977, and outstanding debt was $101.8 billion, leaving farm proprietors an equity of $532.5 billion. These amounts compare with assets of $560.4 billion, debt of $90.8 billion, and equity of $469.6 billion at the beginning of 1976. During 1976, farm real estate value increased $64.0 billion (16 percent) over the revised January 1, 1976, estimate of $397.3 billion. Farm real estate value has been revised downward for the years 1971-76, based on new data collected in the 1974 Census of Agriculture. Livestock and poultry value of $29.1 billion on January 1,1977, was slightly below the value of a year earlier. Machinery and motor vehicles were valued at $73.0 billion, an 11-percent increase from the beginning of 1976. The value of crops stored was an estimated $20.0 billion on January 1, 1977, about the same as a year earlier. The value of household equipment and furnishings rose about 7 percent and on January 1, 1977, stood at $17.4 billion. Financial assets rose about 5 percent to total an estimated $33.5 billion at the beginning of 1977. Farm debt rose at a slightly faster rate than during 1975. On January 1, 1977, farm real estate debt outstanding was $56.1 billion and nonreal estate debt (excluding CCC loans) was $44.7 billion. CCC loans increased from $0.3 billion on January 1,1976, to $1.0 billion on January 1,1977, the highest level since 1973. Balance sheets by value of sales class, capital gains on physical assets, farm production assets, and rates of return on equity were reconstructed to reflect revisions in farm real estate values.
INTACT proteomics in Xenopus
Creators: name: Conlon, F.L.
name: Wasson, L.
name: Amin, N.M.
Publisher: name: Cold Spring Harbor Laboratory Press
Year: 2019

description: Analysis of the molecular mechanisms driving cell specification, differentiation, and other cellular processes can be difficult due to the heterogeneity of tissues and organs. Therefore, it is critical to isolate pure cell populations in order to properly assess the function of certain cell types in the context of a tissue. This protocol describes use of the INTACT (isolation of nuclei tagged in specific cell types) method in Xenopus, followed by proteomics analysis of nuclear protein complexes. The INTACT protocol utilizes two transgenes: (1) a three-part nuclear targeting fusion (NTF) consisting of a nuclear envelope protein (Nup35) that targets the NTF to the nuclear membrane, an enhanced green fluorescent protein (EGFP) cassette for NTF visualization in live animals, and a biotin ligase receptor protein (BLRP) that provides a substrate for the biotinylation of the NTF, and (2) the E. coli ligase BirA (which biotinylates the NTF) tagged to mCherry (for visualization). Either or both transgenes are driven by a tissue-specific promoter, making this protocol easily adaptable to proteomics analyses of immunoprecipitated complexes from INTACT-isolated nuclei of multiple tissue types to determine the composition of protein complexes in pure cell populations.
Balance Sheet of the Farming Sector, 1977
Creators: name: Evans, Carson D.
name: Allen, Philp T.
name: Simunek, Richard W.
name: Walker, Larry
name: Hottel, J. Bruce
name: Evans, Carson D.
name: Allen, Philp T.
name: Simunek, Richard W.
name: Walker, Larry
name: Hottel, J. Bruce
Publisher: name: Unknown
Year: 1977
Subjects: subject: Financial Economics
subject: Production Economics
subject: Farm balance sheet
subject: farm assets
subject: debt and equity
subject: capital gains

description: On January 1, 1977, the value of farm assets totaled $670.9 billion. After deducting $102.1 billion in debts, proprietors' equity in those assets equaled $568.8 billion. At the beginning of 1976 the asset, equity, and debt values were $592.8 billion, $502.0 billion, and $90.8 billion, respectively. Farm real estate accounted for the bulk of the asset value gain, as usual, but other assets also posted a net gain of $15.0 billion. Farm debt rose 1.5 percent in 1976, somewhat faster than in the previous year while equity increased 13.3 percent, about the same as in 1975. On January 1, 1977, the debt to asset ratio was 15.2 percent, equaling that of 1974 and until then, the lowest since 1965. Capital gains on the major production assets (land, machinery, livestock, and stored crops), totaled $441.8 billion from 1960 to 1976, with land accounting for 87 percent of the total. Farm capital accumulation rose $13.0 billion to total $148.1 billion since 1960. Farm production assets, those items most closely associated with producing farm products, totaled $564.1 billion on January 1, 1977. The average value per farm was $204,960. Those values were about 14 percent higher than a year earlier. The rate of return to farm proprietors' equity in those assets for 1976 was 2.4 percent, compared with 4.4 percent in 1975, 5.5 percent in 1974, and 10.2 percent in 1973.
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 46 Nr. 2/3 (2002): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2024

description: Band XLVI (2002), Heft 2/3
description: All'ombra della Loggia. Storia dell'iconografia fotografica della fiorentina Loggia della Signoria...533-556
Cigoli et Marino...510-517
Art Nouveau in Florenz...439-489
Der 'fliegende Kartograph'. Zu dem Federico da Montefeltro und Lorenzo de' Medici gewidmeten Werk "Le septe giornate della geographia" von Francesco Berlinghieri und dem Bild der Erde im Florenz des Quattrocento...270-320
L'educazione di Masaccio. Documenti, problemi, proposte...247-261
Room Temperature Band-like Transport and Hall Effect in a High Mobility Ambipolar Polymer
Creators: name: Senanayak, Satyaprasad P.
name: Ashar, A. Z.
name: Kanimozhi, Catherine
name: Patil, Satish
name: Narayan, K. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The advent of new-class of high-mobility semiconducting polymers opens up a window to address fundamental issues in electrical transport mechanism such as hopping between localized states versus extended state conduction. Here, we investigate the origin of ultra-low degree of disorder (~ 16 meV) and band-like negative temperature (T) coefficient of the field effect electron mobility in a high performance diketopyrrolopyrrole (DPP)-based semiconducting polymer. Models based on the framework of mobility edge (ME) with exponential density of states are invoked to explain the trends in transport. The temperature window over which the system demonstrates de-localized transport was tuned by a systematic introduction of disorder at the transport interface. Additionally, the Hall mobility extracted from Hall-voltage measurements in these devices was found to be comparable to field effect mobility in the high T band-like regime. Comprehensive studies with different combinations of dielectrics and semiconductors demonstrate the effectiveness of rationale molecular design which emphasizes uniform-energetic landscape and low re-organization energy.
The Dependence of Subhalo Abundance on Halo Concentration
Creators: name: Mao, Yao-Yuan
name: Williamson, Marc
name: Wechsler, Risa H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Hierarchical structure formation implies that the number of subhalos within a dark matter halo depends not only on halo mass, but also on the formation history of the halo. This dependence on the formation history, which is highly correlated with halo concentration, can account for the super-Poissonian scatter in subhalo occupation at a fixed halo mass that has been previously measured in simulations. Here we propose a model to predict the subhalo abundance function for individual host halos, that incorporates both halo mass and concentration. We combine results of cosmological simulations with a new suite of zoom-in simulations of Milky Way-mass halos to calibrate our model. We show the model can successfully reproduce the mean and the scatter of subhalo occupation in these simulations. The implications of this correlation between subhalo abundance and halo concentration are further investigated. We also discuss cases in which inferences about halo properties can be affected if this correlation between subhalo abundance and halo concentration is ignored; in these cases our model would give a more accurate inference. We propose that with future deep surveys, satellite occupation in the low-mass regime can be used to verify the existence of halo assembly bias.
description: ApJ in print. Updated to match publication version. 13 pages, 14 figures
Activation cross sections of $α$-particle induced nuclear reactions on hafnium and deuteron induced nuclear reaction on tantalum: production of $^{178}$W/$^{178m}$Ta generator
Creators: name: Tárk'anyi, F.
name: Tak'acs, S.
name: Ditrói, F.
name: Hermanne, A.
name: Ignatyuk, A. V.
name: Uddin, M. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: In the frame of a systematic study of charged particle production routes of medically relevant radionuclei, the excitation function for indirect production of $^{178m}$Ta through $^{nat}$Hf($α$,xn)$^{178}$W-$^{178m}$Ta nuclear reaction was measured for the first time up to 40 MeV. In parallel, the side reactions $^{nat}$Hf($α$,x)$^{179,177,176,175}$W, $^{183,182,178g,177,176,175}$Ta, $^{179m,177m,175}$Hf were also assessed. Stacked foil irradiation technique and $γ$-ray spectrometry were used. New experimental cross section data for the $^{nat}$Ta(d,xn)$^{178}$W reaction are also reported up to 40 MeV. The measured excitation functions are compared with the results of the ALICE-IPPE, and EMPIRE nuclear reaction model codes and with the TALYS 1.4 based data in the TENDL-2013 library. The thick target yields were deduced and compared with yields of other charged particle ((p,4n), (d,5n) and ($^3$He,x)) production routes for $^{178}$W.
Proteomic-based approaches to cardiac development and disease
Creators: name: Conlon, F.L.
name: Dorr, K.M.
Publisher: name: Elsevier Ltd
Year: 2019

description: Congenital malformations, or structural birth defects, are now the leading cause of infant mortality in the United States and Europe (Dolk et al., 2010; Heron et al., 2009). Of the congenital malformations, congenital heart disease (CHD) is the most common (Dolk et al., 2010; Heron et al., 2009). Thus, a molecular understanding of heart development is an essential goal for improving clinical approaches to CHD. However, CHDs are commonly a result of genetic defects that manifest themselves in a spatial and temporal manner during the early stages of embryogenesis, leaving them mostly intractable to mass spectrometry-based analysis. Here, we describe the technologies and advancements in the field of mass spectrometry over the past few years that have begun to provide insights into the molecular and cellular basis of CHD and prospects for these types of approaches in the future.
Balance Sheet of the Farming Sector, 1978
Creators: name: Evans, Carson D.
name: Simunek, Richard W.
name: Evans, Carson D.
name: Simunek, Richard W.
Publisher: name: Unknown
Year: 1978
Subjects: subject: Financial Economics
subject: Production Economics
subject: Farm balance sheet
subject: farm assets
subject: debt
subject: equity
subject: capital gains

description: Farm assets were valued at $709 billion on January 1,1978, and outstanding debt was $120 billion, leaving farm proprietors an equity of $589 billion. These amounts compare with assets of $655 billion, a debt of $103 billion, and an equity of $552 billion at the beginning of 1977. During 1977, farm real estate values increased $42 billion (9 percent) over the January 1, 1977, estimate of $484 billion. Farm real estate value has been revised downward for the years 1970-77, based on final data from the 1974 Census of Agriculture. Livestock and poultry were valued at $32 billion on January 1, 1978, 10 percent above the value of a year earlier. Machinery and motor vehicles were valued at $77 billion, a 7-percent increase from the beginning of 1977. The value of crops stored was an estimated $25 billion, up 12 percent from a year earlier. The value of household equipment and furnishings rose only slightly to $15 billion. Financial assets rose about 5 percent to total an estimated $35 billion. Farm debt rose at a faster rate last year than during 1976. On January 1,1978, farm real estate debt outstanding was $64 billion and nonreal estate debt, excluding CCC (Commodity Credit Corporation) loans, was $51 billion. CCC loans increased from $1.0 billion on January 1, 1977, to a record high $4.5 billion on January 1, 1978. Balance sheets by value of sales class, capital gains on physical assets, farm production assets, and rates of return on equity were reconstructed to reflect revisions in the balance sheet estimates. Balance sheets for each of the 50 States are included for the first time.
An asymmetrical synchrotron model for knots in the 3C 273 jet
Creators: name: Liu, Wen-Po
name: Chen, Y. J.
name: Wang, Chun-Cheng
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: To interpret the emission of knots in the 3C 273 jet from radio to X-rays, we propose a synchrotron model in which, owing to the shock compression effect, the injection spectra from a shock into the upstream and downstream emission regions are asymmetric. Our model could well explain the spectral energy distributions of knots in the 3C 273 jet, and predictions regarding the knots spectra could be tested by future observations.
description: 9 pages, 1 figure, 1 table, new version accepted for publication in ApJ
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
Creators: name: Wasson, L.
name: VanDusen, N.J.
name: Akerberg, B.N.
name: Ma, Q.
name: Pu, W.T.
name: Zhou, P.
name: Zhou, J.
name: Sethi, I.
name: Zhou, B.
name: Wen, T.
name: Dong, R.
name: Li, K.
name: Conlon, F.L.
name: Zhang, B.
name: Gu, F.,
name: Liu, J.
name: Zhang, X.
name: Yuan, G.-C.
name: Dong, K.
Publisher: name: Nature Publishing Group
Year: 2019

description: Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering developmental transcriptional programs. Here we use biotinylated knockin alleles of seven key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to sensitively and reproducibly map their genome-wide occupancy in the fetal and adult mouse heart. These maps show that TF occupancy is dynamic between developmental stages and that multiple TFs often collaboratively occupy the same chromatin region through indirect cooperativity. Multi-TF regions exhibit features of functional regulatory elements, including evolutionary conservation, chromatin accessibility, and activity in transcriptional enhancer assays. H3K27ac, a feature of many enhancers, incompletely overlaps multi-TF regions, and multi-TF regions lacking H3K27ac retain conservation and enhancer activity. TEAD1 is a core component of the cardiac transcriptional network, co-occupying cardiac regulatory regions and controlling cardiomyocyte-specific gene functions. Our study provides a resource for deciphering the cardiac transcriptional regulatory network and gaining insights into the molecular mechanisms governing heart development.
Balance Sheet of the Farming Sector, 1978, Supplement 1 to AIB 416
Creators: name: Evans, Carson D.
name: Simunek, Richard W.
name: Evans, Carson D.
name: Simunek, Richard W.
Publisher: name: Unknown
Year: 1978
Subjects: subject: Financial Economics
subject: Production Economics
subject: Farm balance sheet
subject: farm assets
subject: debt and equity
subject: capital gain

description: Farm assets were valued at $708 billion on January 1,1978, and outstanding debt was $119 billion, leaving farm proprietors an equity of $589 billion. These amounts compare with assets of $655 billion, debt of $103 billion, and equity of $552 billion at the beginning of 1977. Farm real estate value increased $42 billion (9 percent) over the January 1,1977 estimate of $484 billion. Livestock and poultry value of $32 billion was 10 percent above a year earlier. Machinery and motor vehicle value was $75 billion, a 6-percent increase. The value of crops stored was an estimated $25 billion, up 12 percent. The value of household equipment and furnishings rose only slightly, to $15 billion. Financial assets rose about 5 percent to total an estimated $36 billion. Farm debt rose at an accelerated rate. Farm real estate debt outstanding was $63 billion and nonreal estate debt (excluding CCC loans) was $51 billion. CCC loans increased by $3.5 billion to $4.5 billion, a record high. Balance sheets by value of sales class, capital gains on physical assets, farm production assets, and rates of return on equity are reconstructed to reflect revisions in the balance sheet estimates.
Conservation and divergence of protein pathways in the vertebrate heart
Creators: name: Federspiel, J.D.
name: Venkatesh, S.S.
name: Herring, L.E.
name: Tandon, P.
name: Wilczewski, C.M.
name: Cristea, I.M.
name: Conlon, F.L.
name: Wasson, L.
Publisher: name: Public Library of Science
Year: 2019

description: Heart disease is the leading cause of death in the western world. Attaining a mechanistic understanding of human heart development and homeostasis and the molecular basis of associated disease states relies on the use of animal models. Here, we present the cardiac proteomes of 4 model vertebrates with dual circulatory systems: the pig (Sus scrofa), the mouse (Mus musculus), and 2 frogs (Xenopus laevis and Xenopus tropicalis). Determination of which proteins and protein pathways are conserved and which have diverged within these species will aid in our ability to choose the appropriate models for determining protein function and to model human disease. We uncover mammalian- and amphibian-specific, as well as species-specific, enriched proteins and protein pathways. Among these, we find and validate an enrichment in cell-cycle–associated proteins within Xenopus laevis. To further investigate functional units within cardiac proteomes, we develop a computational approach to profile the abundance of protein complexes across species. Finally, we demonstrate the utility of these data sets for predicting appropriate model systems for studying given cardiac conditions by testing the role of Kielin/chordin-like protein (Kcp), a protein found as enriched in frog hearts compared to mammals. We establish that germ-line mutations in Kcp in Xenopus lead to valve defects and, ultimately, cardiac failure and death. Thus, integrating these findings with data on proteins responsible for cardiac disease should lead to the development of refined, species-specific models for protein function and disease states.
Initiating Events in Direct Cardiomyocyte Reprogramming
Creators: name: Zou, M.
name: Qian, L.
name: Villasmil, M.
name: Wang, L.
name: Conlon, F.L.
name: Greco, T.M.
name: Cristea, I.M.
name: Sauls, K.
Publisher: name: Elsevier B.V.
Year: 2018

description: Direct reprogramming of fibroblasts into cardiomyocyte-like cells (iCM) holds great potential for heart regeneration and disease modeling and may lead to future therapeutic applications. Currently, application of this technology is limited by our lack of understanding of the molecular mechanisms that drive direct iCM reprogramming. Using a quantitative mass spectrometry-based proteomic approach, we identified the temporal global changes in protein abundance that occur during initial phases of iCM reprogramming. Collectively, our results show systematic and temporally distinct alterations in levels of specific functional classes of proteins during the initiating steps of reprogramming including extracellular matrix proteins, translation factors, and chromatin-binding proteins. We have constructed protein relational networks associated with the initial transition of a fibroblast into an iCM. These findings demonstrate the presence of an orchestrated series of temporal steps associated with dynamic changes in protein abundance in a defined group of protein pathways during the initiating events of direct reprogramming. Translational application of direct reprogramming into cardiomyocyte-like cells is limited by our understanding of the molecular mechanisms underlying initiating steps. Sauls et al. define an orchestrated series of temporal changes in the abundance of proteins and protein pathways during early stages of cardiac reprogramming.
Balance Sheet of the Farming Sector, 1979 Supplement to AIB No. 430
Creators: name: Evans, Carson D.
name: Evans, Carson D.
Publisher: name: Unknown
Year: 1980
Subjects: subject: Financial Economics
subject: Production Economics
subject: Farm balance sheet
subject: farm assets
subject: debt and equity
subject: capital gains

description: Farm assets were valued at $820 billion on January 1, 1979, and outstanding debt was $137 billion, leaving farm proprietors an equity of $683 billion. Each of these amounts stood about 15 percent above value on January 1, 1978. Farm real estate was valued at $600 billion, up $74 billion. The value of other farm physical assets rose $31 billion and financial assets were up $2 billion. Farm real estate debt outstanding was $72 billion and nonreal estate debt (excluding CCC loans) was $60 billion. CCC loans totaled $5.2 billion, a record high. Balance sheets by value of sales class, capital gains on physical assets, farm production assets, and rates of return on equity are reconstructed to reflect revisions in the balance sheet estimates.
An Enhanced Genetic Algorithm for the Generalized Traveling Salesman Problem
Creators: name: Jafarzadeh, Hassan
name: Moradinasab, Nazanin
name: Elyasi, Milad
Publisher: name: figshare
Year: 2022
Subjects: subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: The generalized traveling salesman problem (GTSP) deals with finding the minimum-cost tour in a clustered set of cities. In this problem, the traveler is interested in finding the best path that goes through all clusters. As this problem is NP-hard, implementing a metaheuristic algorithm to solve large-scale problems is inevitable. The performance of these algorithms can be intensively promoted by other heuristic algorithms. In this study, a search method is developed that improves the quality of the solutions and competition time considerably in comparison with Genetic Algorithm. In the proposed algorithm, the genetic algorithms with the Nearest Neighbor Search (NNS) are combined and a heuristic mutation operator is applied. According to the experimental results on a set of standard test problems with symmetric distances, the proposed algorithm finds the best solutions in most cases with the least computational time. The proposed algorithm is highly competitive with the published until now algorithms in both solution quality and running time
Evidence for Half-Metallicity in n-type HgCr2Se4
Creators: name: Guan, Tong
name: Lin, Chaojing
name: Yang, Chongli
name: Shi, Youguo
name: Ren, Cong
name: Li, Yongqing
name: Weng, Hongming
name: Dai, Xi
name: Fang, Zhong
name: Yan, Shishen
name: Xiong, Peng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: High quality HgCr$_2$Se$_4$ single crystals have been investigated by magnetization, electron transport and Andreev reflection spectroscopy. In the ferromagnetic ground state, the saturation magnetic moment of each unit cell corresponds to an integer number of electron spins (3 $μ_B$/Cr$^{3+}$), and the Hall effect measurements suggest n-type charge carriers. Spin polarizations as high as $97\%$ were obtained from fits of the differential conductance spectra of HgCr$_2$Se$_4$/Pb junctions with the modified Blonder-Tinkham-Klapwijk (BTK) theory. The temperature and bias-voltage dependencies of the sub-gap conductance are consistent with recent theoretical calculations based on spin active scatterings at a superconductor/half metal interface. Our results suggest that n-HgCr$_2$Se$_4$ is a half metal, in agreement with theoretical calculations that also predict undoped HgCr$_2$Se$_4$ is a magnetic Weyl semimetal.
description: 6 pages, 4 figures, to appear in PRL
Synthesis of New Bis(Indolyl)Methanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities
Creators: name: Heravi, Majid Mommahed
name: Soltani, Sara
name: Montazeri, Naser
name: Zeydi, Masoud Mohammadi
Publisher: name: figshare
Year: 2020
Subjects: subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30601 Catalysis and Mechanisms of Reactions
subject: 30301 Chemical Characterisation of Materials
subject: 39901 Environmental Chemistry (incl. Atmospheric Chemistry)

description: Benzylsulfamic acid has been prepared and introduced as a new heterogeneous acid catalyst. This reagent was used for the synthesis of new bis(indolyl)methanes 3a – 3f via reaction of bis-aldehydes 1 with indoles 2 at 100°C. All reactions were performed under solvent-free conditions with high to excellent yields. The synthesized bis(indolyl)methanes were evaluated for their antibacterial and antifungal activities.
Pinning networks of coupled dynamical systems with Markovian switching couplings and event-triggered diffusions
Creators: name: Lu, Wenlian
name: Han, Yujuan
name: Chen, Tiaping
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper, stability of linearly coupled dynamical systems with feedback pinning algorithm is studied. Here, both the coupling matrix and the set of pinned-nodes vary with time, induced by a continuous-time Markov chain with finite states. Event-triggered rules are employed on both diffusion coupling and feedback pinning terms, which can efficiently reduce the computation load, as well as communication load in some cases and be realized by the latest observations of the state information of its local neighborhood and the target trajectory. The next observation is triggered by certain criterion (event) based on these state information as well. Two scenarios are considered: the continuous monitoring, that each node observes the state information of its neighborhood and target (if pinned) in an instantaneous way, to determine the next triggering event time, and the discrete monitoring, that each node needs only to observe the state information at the last event time and predict the next triggering-event time. In both cases, we present several event-triggering rules and prove that if the conditions that the coupled system with persistent coupling and control can be stabilized are satisfied, then these event-trigger strategies can stabilize the system, and Zeno behaviors are excluded in some cases. Numerical examples are presented to illustrate the theoretical results.
description: 17 pages, 9 figures
AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta
Creators: name: Vercammen, D.
name: Coll, N.S.
name: Lema Asqui, S.
name: Dangl, J.L.
name: Van Breusegem, F.
name: Serrano, I.
name: Conlon, F.L.
name: Rivas, S.
name: Valls, M.
Publisher: name: Blackwell Publishing Ltd
Year: 2018

description: The hypersensitive response (HR) is a localized programmed cell death phenomenon that occurs in response to pathogen recognition at the site of attempted invasion. Despite more than a century of research on HR, little is known about how it is so tightly regulated and how it can be contained spatially to a few cells. AtMC1 is an Arabidopsis thaliana plant metacaspase that positively regulates the HR. Here, we used an unbiased approach to identify new AtMC1 regulators. Immunoaffinity purification of AtMC1-containing complexes led us to the identification of the protease inhibitor AtSerpin1. Our data clearly showed that coimmunoprecipitation between AtMC1 and AtSerpin1 and formation of a complex between them was lost upon mutation of the AtMC1 catalytic site, and that the AtMC1 prodomain was not required for the interaction. AtSerpin1 blocked AtMC1 self-processing and inhibited AtMC1-mediated cell death. Our results constitute an in vivo example of a Serpin acting as a suicide inhibitor in plants, reminiscent of the activity of animal or viral serpins on immune/cell death regulators, including caspase-1. These results indicate a conserved function of a protease inhibitor on cell death regulators from different kingdoms with unrelated modes of action (i.e. caspases vs metacaspases).