cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Wund-pH-Wert und -Temperatur und deren diagnostische und therapeutische Bedeutung
Creators: name: Eberlein, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Als wichtiger, aber immer noch nicht in jeder Beziehung geklärter Parameter bleiben der Wund-pH-Wert und die Wundtemperatur im Fokus wissenschaftlicher Betrachtungen hinsichtlich der Diagnose und Behandlung von chronischen Wunden.    Durch zahlreiche Belege wird die Aussage gestützt,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
On Fabry's Gap Theorem
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30A10

description: By combining Turán's proof of Fabry's gap theorem with a gap theorem of P. Szüsz we obtain a gap theorem which is more general then both these theorems.
Absolute shifts of Fe I and Fe II lines in solar active regions (disk center)
Creators: name: Brandt, P. N.
name: Gadun, A. S.
name: Sheminova, V. A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We estimated absolute shifts of Fe I and Fe II lines from Fourier-transform spectra observed in solar active regions. Weak Fe I lines and all Fe II lines tend to be red-shifted as compared to their positions in quiet areas, while strong Fe I lines, whose cores are formed above the level $\log τ_5\approx-3$ (about 425 km), are relatively blue-shifted, the shift growing with decreasing lower excitation potential. We interpret the results through two-dimensional MHD models, which adequately reproduce red shifts of the lines formed deep in the photosphere. Blue shifts of the lines formed in higher layer do not gain substance from the models.
description: 12 pages, 4 figures, 2 tables. Published in Kinematika i Fizika Nebesnykh Tel (in Russian), Kinematics Phys. Celest. Bodies (in English)
Antimicrobial stewardship and education in optometry
Creators: name: Schmid, Katrina L
name: Backhouse, Simon
name: Harduwar, Kieran
name: Jalbert, Isabelle
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Science Policy

description: Antimicrobial stewardship aims to improve how antibiotics are prescribed by clinicians and used by patients, to ensure safe appropriate use, and to prevent and contain antimicrobial resistance. Australian optometrists can prescribe a range of antimicrobial agents, but to what extent they consider antimicrobial stewardship is not known. This study evaluated what final-year optometry students and optometrists understood about antimicrobial stewardship in eye care and considered relevance to oral prescribing and education. A knowledge, attitude, and practice (KAP) questionnaire was developed comprising four sections: i) demographic questions, ii) 10 multiple choice questions regarding Knowledge about antimicrobial agents and likely pathogens, diagnosis, treatment, and preventing resistance, iii) 10 Likert rating scale questions about thoughts and Attitudes, iv) mix of question types (5× MCQ: course of action, 16 Likert scale: confidence) related to Practice (diagnosis, management, and prescribing). Descriptive analyses were conducted (medians, mean±SD, and distributions). Thirteen students and 36 optometrists completed the survey. Both groups had a good understanding of microbial resistance and antibiotic prescribing for ocular conditions; average knowledge scores were 9.2 ± 0.7 and 8.7 ± 1.1 for students and practitioners, respectively. Scores were neutral to agree for questions related to the need for more educational programs. The answers of practice-related MCQs had a dichotomy of answers indicating a diversity of opinion, as can be the case in practice. Average total practice confidence scores were approximately 57/80 for students and 68/80 for optometrists. Optometrists and students were very confident in their ability to conduct an appropriate case history and use their knowledge and clinical skills, including slit lamp anterior eye assessment. The lowest confidence scores were for conducting microbial testing, i.e. taking swabs for pathology. Student and optometrist knowledge, attitudes, and practice around antimicrobial stewardship were high and in line with other health professions globally. There is scope for increased stewardship training.
Transfer of the members of the genus Brachiola (microsporidia) to the genus Anncaliia based on ultrastructural and molecular data
Creators: name: Franzen, Caspar
name: Nassonova, Elena S
name: Schölmerich, Jürgen
name: Issi, Irma V.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Two microsporidian genera, AnncaliiaIssi, Krylova, & Nicolaeva 1993 and BrachiolaCali et al. 1998, possess a Nosema-type life cycle and unique cell surface ornamentations, which include precocious electron-dense coating of the plasmalemma and a variety of secretory structures deposited on the parasite surface and scattered in the host cell cytoplasm. Comparative analysis of ultrastructure of Anncaliia meligethi (the type species of the genus Anncaliia) and of B. vesicularum and B. algerae (the best-studied members of the genus Brachiola) clearly demonstrated that these microsporidia share many distinctive morphological features. The comparison of small subunit ribosomal DNA sequences showed high sequence identity of A. meligethi and B. algerae. Phylogenetic analyses indicated that the rDNA sequences of A. meligethi clustered with those of B. algerae suggesting a close relatedness of these microsporidia. The combination of molecular and morphological data provided clear evidence that these microsporidia belong to the same genus and therefore, warranted emendation of the genus Anncaliia and establishments of the following new combinations: Anncaliia vesicularum nov. comb., Anncaliia algerae nov. comb., Anncaliia connori nov. comb., and Anncaliia gambiae nov. comb. The generic name Brachiola is submerged according to the rule of priority.
Association of maternal folate and vitamin B12 status with birthweight and gestational age at birth in mother-newborn dyads residing in British Columbia
Creators: name: Qanaq Adnan, Dalal
Publisher: name: University of British Columbia
Year: 2018

description: Birthweight and gestational age at birth have been inversely associated with chronic disease risk in later life. The vitamins folate and vitamin B12 (B12) have interdependent metabolic functions that are essential for fetal growth. Maternal folate and B12 concentrations during pregnancy have been positively associated with birthweight and gestational age at birth; however, the findings from the literature are inconsistent. The objective of this research was to evaluate the association of maternal serum folate and B12 biomarker concentrations, combined and individually, with birthweight and gestational age at birth. This retrospective cohort study included biobanked non-fasting serum samples and data from 674 apparently healthy pregnant women of South Asian and European ethnicity residing in Lower Mainland, British Columbia (BC). Maternal serum samples, collected in the first and second trimesters of pregnancy, were retrieved from the BC Prenatal Genetic Screening Program and analysed for folate and B12 biomarker concentrations. Birth outcome data were retrieved from the BC Newborn Screening Program. The association of folate and B12 biomarker concentrations with birth outcomes was assessed using multiple linear regression models with adjustment for confounding factors, including infant sex, ethnicity and maternal age. The prevalence of low birthweight, preterm and small-for-gestational-age were 1.9%, 8.9% and 0.88%, respectively. The combined maternal folate and B12 status, in either trimester, was not associated with birthweight or gestational age at birth. Maternal B12 biomarker concentrations individually, in either trimester, were not or only weakly associated with birth outcomes. Second-trimester maternal folate concentrations of the second, third and fourth quartile group (Q2=55.5-69.3, Q3=69.3-87.8, Q4≥87.8 nmol/L, respectively) were associated with an approximate 0.6-week (i.e., 4-day) increase in gestational age at birth, compared to the iii reference group (Q1≤55.5 nmol/L) (95% CI: 0.28, 1.02, p=0.02; 95% CI: 0.23, 0.95, p=0.03, 95% CI: 0.16, 0.89, p=0.005, respectively). In conclusion, early pregnancy folate and B12 status were neither combined nor individually associated with birthweight in this sample. Due to the vitamins’ importance in fetal growth and development, the association between maternal folate and B12 status and birth outcomes warrants further investigation in a population with a higher prevalence of low birthweight and preterm birth.
title: Blickdiagnose und Behandlung von Inkontinenz-Assoziierter Dermatitis (IAD)
Creators: name: Bauernfeind, Gonda
name: Strupeit, Steve
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Im Expertenstandard Dekubitusprophylaxe in der Pflege (DNQP 2017) heißt es, dass eine Pflegefachkraft in der Lage sein muss, einen Dekubitus Kategorie 1 von einer Inkontinenzassoziierten Dermatitis (IAD) zu unterscheiden sowie traumatisch oder iatrogen bedingte Hautveränderungen, die ein ähnliches[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Accepting Hybrid Networks of Evolutionary Processors with Special Topologies and Small Communication
Creators: name: Dassow, Jürgen
name: Manea, Florin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computational Complexity (cs.CC)
subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: Starting from the fact that complete Accepting Hybrid Networks of Evolutionary Processors allow much communication between the nodes and are far from network structures used in practice, we propose in this paper three network topologies that restrict the communication: star networks, ring networks, and grid networks. We show that ring-AHNEPs can simulate 2-tag systems, thus we deduce the existence of a universal ring-AHNEP. For star networks or grid networks, we show a more general result; that is, each recursively enumerable language can be accepted efficiently by a star- or grid-AHNEP. We also present bounds for the size of these star and grid networks. As a consequence we get that each recursively enumerable can be accepted by networks with at most 13 communication channels and by networks where each node communicates with at most three other nodes.
description: In Proceedings DCFS 2010, arXiv:1008.1270
Rare-gas clusters in intense VUV, XUV and soft x-ray pulses: Signatures of the transition from nanoplasma-driven cluster expansion to Coulomb explosion in ion and electron spectra
Creators: name: Arbeiter, Mathias
name: Fennel, Thomas
Publisher: name: arXiv
Year: 2010
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: We investigate the wavelength dependent ionization, heating, and expansion dynamics of medium-sized rare-gas clusters (Ar$_{923}$) under intense femtosecond short-wavelength free electron laser pulses by quasi-classical molecular dynamics simulations. A comparison of the interaction dynamics for pulses with $\hbarω$=20, 38, and 90\,eV photon energy at fixed total excitation energy indicates a smooth transition from plasma-driven cluster expansion, where predominantly surface ions are expelled by hydrodynamic forces, to quasi-electrostatic behavior with almost pure Coulomb explosion. Corresponding signatures in the time-dependent cluster dynamics as well as in the final ion and electron spectra support that this transition is linked to a crossover in the electron emission processes. The resulting signatures in the electron spectra are shown to be even more reliable for identifying the cluster expansion mechanisms than ion energy spectra itself.
description: 12 pages, 3 figures
Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas
Creators: name: Hau, Peter
name: Kunz-Schughart, Leoni A.
name: Rümmele, Petra
name: Arslan, Füsun
name: Dörfelt, Anett
name: Koch, Horst
name: Lohmeier, Annette
name: Hirschmann, Birgit
name: Müller, Adolf
name: Bogdahn, Ulrich
name: Bosserhoff, Anja-Katrin
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: anaplastic astrocytoma; glioblastoma; high-grade gliomas; induction; prognosis; Tenascin-C; TGF-ß1
subject: 610 Medizin

description: BACKGROUND: Tenascin-C is an extracellular matrix protein known to correlate with prognosis in patients with glioblastoma, probably by stimulation of invasion and neoangiogenesis. Transforming Growth Factor-beta1 (TGF-beta1) plays an important role in the biology of high-grade gliomas, partly by regulating invasion of these tumors into parenchyma. This study was designed to evaluate if TGF-beta1 induces the expression and deposition of Tenascin-C in the extracellular matrix of high-grade gliomas which may be pivotal for the invasion of these tumors into healthy parenchyma. METHODS: A series of 20 high-grade gliomas was stained immunohistochemically with Tenascin-C- and TGF-beta1- specific antibodies. Expression levels of both proteins were evaluated and correlated with each other, time to progression and molecular and morphological markers of invasion. A quantitative PCR assay was performed evaluating the induction of Tenascin-C mRNA by treatment with TGF-beta1 in vitro. RESULTS: Tenascin-C was expressed in 18 of 19 (95%) evaluable tumors, whereas 14 of 20 tumors (70%) expressed TGF-beta1 in a significant percentage of cells. Treatment with TGF-beta1 did induce the expression of Tenascin-C at the mRNA and protein level in vitro. The expression of Tenascin-C and TGF-beta1 did neighter statistically correlate with each other nor with time to progression. CONCLUSION: In our series, Tenascin-C and TGF-beta1 were expressed in the vast majority of high-grade gliomas. We could not detect a correlation of one of the proteins with time to progression. Nevertheless, we describe induction of Tenascin-C by TGF-beta1, possibly providing a mechanism for the invasion of high-grade gliomas into healthy parenchyma.
title: 3D Segmentierung und Telemedizin
Creators: name: Kellermann, Kerstin
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: In diesem Vortrag werden digitale Innovationen der Medizintechnik vorgestellt, welche im intersektionalen und interdisziplinären Workflow der Wundversorgung Hand in Hand gehen.    Durch die Verbindung von zwei modernen kontaktlosen Aufnahmeverfahren – hyperspektrale Bildaufnahmen und 3D-Scan[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
title: Physikalische Grundlagen der 3D Hyperspektralanalyse
Creators: name: Marotz, Jörg
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hyperspectral Imaging hat als kontaktfreie, unbelastende und bildgebende Messmethode insbesondere zur Bestimmung von Durchblutungsparametern in den letzten Jahren ein deutlich zunehmendes Interesse im medizinischen Anwendungsbereich erfahren und entsprechende Forschungsaktivitäten nehmen stark [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Representing Small Ordinals by Finite Automata
Creators: name: Ésik, Zoltan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences
subject: F.4.3

description: It is known that an ordinal is the order type of the lexicographic ordering of a regular language if and only if it is less than omega^omega. We design a polynomial time algorithm that constructs, for each well-ordered regular language L with respect to the lexicographic ordering, given by a deterministic finite automaton, the Cantor Normal Form of its order type. It follows that there is a polynomial time algorithm to decide whether two deterministic finite automata accepting well-ordered regular languages accept isomorphic languages. We also give estimates on the size of the smallest automaton representing an ordinal less than omega^omega, together with an algorithm that translates each such ordinal to an automaton.
description: In Proceedings DCFS 2010, arXiv:1008.1270
Resilience and its associated factors in optometry students from eight institutions across six countries
Creators: name: Lim, Simon Si Ming
name: Brooker, Abi
name: Giampiccolo, Alessia
name: Klidis, Stan
name: Lim, Hui Shan
name: Mei, Melinda
name: Narayanan, Anuradha
name: Neuville, Jessica
name: Putnam, Nicole M
name: Srinivasan, Krithica
name: Ting, Patrick WK
name: Tsui, Macy
name: Woo, Kenny Ziliang
name: Zoumboukos, Diana T
name: Lek, Jia Jia
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Resilience is a key enabler for healthcare professionals including optometrists, to cope with adversities and practice self-care. Evaluating the levels of resilience and its associated factors in optometry students can lead to the development of appropriate intervention strategies for academic and professional success. The moderately high prevalence of mental health issues and burnout among optometry students suggests a need to equip the next generation of optometrists with the necessary skills to enhance mental health. Resilience has been shown to mitigate burnout among healthcare professionals and offer personal and professional benefits. Additionally, resilience education during healthcare student training can enhance mental health and wellbeing, leading to better patient care. This study aims to evaluate resilience levels and its associated factors (self-efficacy, mindfulness, positive and negative affect, and coping strategies) in optometry students. Students enrolled in optometry schools across eight institutions in six countries were invited to participate in an online survey within the period of April 2023 – January 2024. The survey comprised of demographic data, existing and validated questionnaires on resilience, self-efficacy, mindfulness, positive and negative affect, and coping strategies. Descriptive statistics and linear regressions were used for analysis. A total of 294 valid responses were collected. There were no significant differences in resilience scores between countries. Greater resilience (p < 0.05) was associated with older age, higher academic grades and having no financial assistance. Additional predictors of greater resilience included higher self-efficacy, mindfulness, positive affect and acceptance scores, and lower behavioural disengagement scores. Identifying factors that affect resilience in optometry students provides information for targeted strategies that enhance resilience. More work is required to understand the generalisability of these results, impact of culture on resilience, and appropriate intervention methods.
Infrared study of the charge-ordered multiferroic LuFe(2)O(4)
Creators: name: Vitucci, F. M.
name: Nucara, A.
name: Nicoletti, D.
name: Sun, Y.
name: Li, C. H.
name: Soret, J. C.
name: Schade, U.
name: Calvani, P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The reflectivity of a large LuFe(2)O(4) single crystal has been measured with the radiation field either perpendicular or parallel to the c axis of its rhombohedral structure, from 10 to 500K, and from 7 to 16000 cm-1. The transition between the two-dimensional and the three-dimensional charge order at T_(CO) = 320 K is found to change dramatically the phonon spectrum in both polarizations. The number of the observed modes above and below T_(CO), according to a factor-group analysis, is in good agreement with a transition from the rhombohedral space group R{bar 3}m to the monoclinic C2/m. In the sub-THz region a peak becomes evident at low temperature, whose origin is discussed in relation with previous experiments.
description: Physical Review B in press
Seventy-three Catholic tracts on various subjects.
Creators: name: Not Assigned
Publisher: name: University of Notre Dame
Year: 2023

description:
 Imperfect copy. Several tracts lacking.
 Includes tracts intended to convert and remove the prejudices of non-Catholics as well as tracts to instruct Catholics.
 Various subjects include: religious indifference, uncertainty, the truth of Catholic claims, doctrines such as the Trinity and the Incarnation, lenten and Christmas practices, the sacraments, papal authority, veneration of saints, and Catholic education.
 To the clergy we recommend Tract 50 [How to utilize the press] as one intended to place before them a practical method of circulating Catholic literature among their people.
Graph-Controlled Insertion-Deletion Systems
Creators: name: Freund, Rudolf
name: Kogler, Marian
name: Rogozhin, Yurii
name: Verlan, Sergey
Publisher: name: arXiv
Year: 2010
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: In this article, we consider the operations of insertion and deletion working in a graph-controlled manner. We show that like in the case of context-free productions, the computational power is strictly increased when using a control graph: computational completeness can be obtained by systems with insertion or deletion rules involving at most two symbols in a contextual or in a context-free manner and with the control graph having only four nodes.
description: In Proceedings DCFS 2010, arXiv:1008.1270
Development of enzymatic renewable hydrocarbon fuel production from triacylglycerol: Performance evaluation, process intensification and feasibility studies
Creators: name: Ng, Wei Zhe
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 400499
subject: Chemical engineering not elsewhere classified

description: Efforts to address the climate crisis have intensified, focusing on reducing greenhouse gas emissions by replacing fossil fuels with biofuels. Biodiesel, the most common biofuel, faces challenges like poor cold flow properties and stability issues, prompting interest in renewable hydrocarbon (HC) fuels. Conventional HC production relies on costly, harsh methods, while enzyme-based methods are limited by enzyme cost and slow reactions. This study introduces CO2-based ionic liquids (ILs) to improve enzymatic efficiency for the hydrolysis and decarboxylation reaction. Optimized conditions enhanced fatty acid conversion and HC yields, showcasing a cost-effective, eco-friendly approach to advancing renewable HC fuel production.
Helicity-dependent reaction \vec γ\vec d\to πNN and its contribution to the GDH sum rule for the deuteron
Creators: name: Levchuk, M. I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Helicity-dependent incoherent pion photoproduction in the reaction \vec γ\vec d\to πNN is studied in the framework of the diagrammatic approach. Contributions to the reaction amplitude from diagrams corresponding to impulse approximation as well as NN and πN interactions in the final state have been evaluated. The elementary γN\to πN operator is taken from the MAID and SAID models. A detailed comparison of the predictions with recent experimental data by the GDH and A2 collaborations at energies below 500 MeV is presented. Reasonable agreement with the data on the yields and cross sections for polarized beam and polarized target has been achieved in all channels. The unpolarized data of the GDH and A2 collaborations have also been analyzed within the approach. A strong overestimation for the neutral channel has been found. At the same time, the model provides a quite satisfactory description of the unpolarized data for the charged channels. The sensitivity of the obtained results to the choice of the elementary γN\to πN operator is discussed in detail. The contribution of the γd\to πNN reaction to the GDH sum rule for the deuteron up to a photon energy of 1.65 GeV has been evaluated with the result of 235\pm 25 \mub.
description: 17 pages, 14 figures, references added
Additional file 1 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Creators: name: Miedema, Anneke
name: Gerrits, Emma
name: Brouwer, Nieske
name: Jiang, Qiong
name: Kracht, Laura
name: Meijer, Michel
name: Nutma, Erik
name: Peferoen-Baert, Regina
name: Pijnacker, Anna T. E.
name: Wesseling, Evelyn M.
name: Wijering, Marion H. C.
name: Gabius, Hans-Joachim
name: Amor, Sandra
name: Eggen, Bart J. L.
name: Kooistra, Susanne M.
Publisher: name: figshare
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Supplementary data related to figures 1 and 2. (a) Representative images of DAB staining for PLP and HLA-DR that was used for sample scoring. (b) Heatmap depicting gene expression of a manually chosen set of immediate-early genes. Rows and columns are ordered by hierarchical clustering. (c) Box plots depicting sum of IEG expression (top), HSPA1A expression level (middle) and SOCS3 expression level (bottom). (d) Box plots depicting module eigengenes per sample group derived from the WGCNA on 68 white matter brain tissue samples. (e) Bar plots depicting gene ontology analysis of magenta and pink modules. *:p <0.01; **:p < 0.001; ***: p < 0.0001. Abbreviations: CWM = control white matter (CTR donors); NAWM = normal appearing white matter (MS donors); WML = white matter lesion (MS donors); IEGs = immediate early genes.
Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
Creators: name: Dietmaier, Wolfgang
name: Bettstetter, Marcus
name: Wild, Peter J.
name: Woenckhaus, Matthias
name: Rümmele, Petra
name: Hartmann, Arndt
name: Dechant, Stefan
name: Blaszyk, Hagen
name: Pauer, Armin
name: Klinkhammer-Schalke, Monika
name: Hofstädter, Ferdinand
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: colon cancer; Maspin; prediction; 5-flourouracil; chemotherapy
subject: 610 Medizin

description: Maspin, a member of the Serpin protease inhibitor family, is overexpressed in poorly differentiated colorectal tumors and more frequently found in tumors with microsatellite instability. Immunohistochemical nuclear Maspin staining is predominantly seen in tumor cells at the invasion front of such cancers, suggesting that this molecule is associated with local tumor cell infiltration and aggressiveness. In a retrospective study, we studied nuclear Maspin expression as a potential prognostic tool in a total of 172 primary stage III colon cancers by immunohistochemistry. Of those 172 patients, 76 were treated by surgery only, and 96 patients received additional adjuvant 5-fluorouracil (5-FU) based chemotherapy. Nuclear Maspin expression was an independent adverse prognostic factor for overall survival in our patient cohort (hazard ratio 2.08; 95% CI, 1.13-3.81; p = 0.018). However, patients with primary tumors expressing Maspin in the nucleus showed a significant treatment benefit from 5-FU chemotherapy (hazard ratio 0.384; 95% CI, 0.188-0.784; p = 0.009) compared to adjuvantly treated patients whose tumors did not express this molecule. Nuclear Maspin expression is highly predictive of 5-FU chemotherapy response in patients with advanced stage colon cancer. Patients with negative immunohistochemical Maspin expression do not benefit from 5-FU treatment and may be candidates for an alternative (non-5-FU based) adjuvant therapy regime.
An additive property of almost periodic sets
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11K70

description: We show that a set is almost periodic if and only if the associated exponential sum is concentrated in the minor arcs. Hence binary additive problems involving almost periodic sets can be solved using the circle method.
Botulinum toxin therapy of migraine and tension-type headache: comparing different botulinum toxin preparations
Creators: name: Schulte-Mattler, W. J.
name: Martinez-Castrillo, J. C.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: botulinum toxin; headache; migraine; tensiontype headache; therapy
subject: 610 Medizin

description: Most of the initial reports on botulinum toxin in tension-type headache (TTH) and in migraine were positive. Unfortunately, these results were not reproduced in well-designed, randomized controlled trials. So far, doses from 20 U (Botox) to 500 U (Dysport) have been studied in patients with chronic TTH, and doses from 16 to 200 U (Botox) in patients with migraine. Overall, there is no evidence for a beneficial effect of botulinum toxin, although trends favoring botulinum toxin were reported. Experience with botulinum toxin type B (Myobloc/NeuroBloc) is limited and similar to the experience with the type A. Thus, a widespread use of botulinum toxin therapy in headache can currently not be recommended.
A mobile collaboration and decision support system for the medical emergency departement
Creators: name: Brodbeck, Dominique
name: Degen, Markus
name: Reiss, Maximilian
Publisher: name: SciTePress
Year: 2012
Subjects: subject: 500 - Naturwissenschaften und Mathematik

description: A hospital emergency department is a complex work environment, where the availability of the right information at the right time is crucial for efficient and safe operation. The current technology in use for communication and information management is mostly based on telephones and stationary personal computers. Modern smartphones with their computational power, voice, image, and video capabilities have the potential to play a significant role in improving the flow of information in the emergency department. We developed a system that explicitly supports the work flows of an emergency department. In addition to mobile access to patient data and notifications about the availability of diagnostic findings, it provides the possibility to supply media captured on-site to the patient record, and directly supports the consultation process.
Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb
Creators: name: Winner, Beate
name: Geyer, Martin
name: Couillard-Despres, Sebastien
name: Aigner, Robert
name: Bogdahn, Ulrich
name: Aigner, Ludwig
name: Kuhn, Georg
name: Winkler, Jürgen
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Parkinson disease; Lesion; Adult neurogenesis; Neural progenitor/stem cell; BrdU; TH; Pax-6; Cell fate; 6-OHDA
subject: 610 Medizin

description: Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/olfactory bulb system as well as in the hippocampus. Here, we study the impact of 6-hydroxydopamine (6-OHDA) lesions to the medial forebrain bundle on proliferation and neuronal differentiation of newly generated cells in the SVZ/olfactory bulb axis in adult rats. Proliferation in the SVZ decreased significantly after dopaminergic deafferentation. However, the number of neural progenitor cells expressing the proneuronal cell fate determinant Pax-6 increased in the SVZ. Survival and quantitative cell fate analysis of newly generated cells revealed that 6-OHDA lesions induced opposite effects in the two different regions of neurogenesis in the olfactory bulb: a transient decrease in the granule cell layer contrasts to a sustained increase of newly generated neurons in the glomerular layer. These data point towards a shift in the ratio of newly generated interneurons in the olfactory bulb layers. Dopaminergic neurogenesis in the glomerular layer tripled after lesioning and consistent with this finding, the total number of tyrosine hydroxylase (TH)-positive cells increased. Thus, loss of dopaminergic input to the SVZ led to a distinct cell fate decision towards stimulation of dopaminergic neurogenesis in the olfactory bulb glomerular layer. This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons.
Biochemical and crystallographic studies of unusual imino-acid-reducing enzymes
Creators: name: Guo, Jin
Publisher: name: University of British Columbia
Year: 2020

description: Chiral amine moieties are widely distributed in bioactive natural products and pharmaceutical ingredients. NAD(P)H-dependent imine reductases (IREDs) have been identified as potential biocatalysts for chiral amine synthesis via asymmetric reduction of the imine substrates. In this work, I characterized two unusual imino-acid-reducing enzymes, Punc5 and Bsp5, from the D-2-hydroxy-acid dehydrogenase (DHDH) family. The DHDH enzymes are known for reducing α-keto acids directly to the corresponding chiral hydroxy acids; however, both Punc5 and Bsp5 demonstrate imine reductase activity. Specifically, when coupled with L-arginine oxidase Ind4, both enzymes can use the coenzyme NAD(P)H to stereo-specifically reduce the Ind4 products didedydroarginine and dedydroarginine to D-4,5-dehydroarginine and D-arginine, respectively. Furthermore, Punc5 shows a DHDH activity, converting 2-ketoarginine to 5-guanidino-2-hydroxypentanoic acid. Both IREDs and DHDHs belong to the NAD(P)H-dependent oxidoreductase family; however, imine reduction catalyzed by DHDHs had never been reported before. To understand how Punc5 and Bsp5 evolved from DHDHs with asymmetric imino-acid-reducing activities, and to offer insights into NAD(P)H-dependent oxidoreductases’ chemoselectivity, I obtained ~1.6 Å resolution ternary structures of each enzyme bound with coenzyme NADPH and product D-arginine. These ternary structures of Punc5 and Bsp5 at high resolution closely resemble typical DHDHs; however, the spatial relationship of the coenzyme, product, and catalytic residues within the active site suggests a different catalytic mechanism from typical DHDHs. Structure-guided mutagenesis work uncovered an essential residue Tyr97 for substrate binding in Punc5. Biochemical characterization of the Punc5-Y97F variant suggests imine reduction under the acidic condition is a more facile reaction compared to ketone reduction as Punc5-Y97F is active towards imino acids, but it is inactive towards 2-ketoarginine. This unique imino-acid-reducing activity demonstrated by Punc5 and Bsp5 indicate that other subfamilies of NAD(P)H-dependent oxidoreductases besides known IREDs could also have the potential to produce chiral amines and be applied in pharmaceutical industry. Besides, our work offered three-dimensional frameworks for understanding how these unusual imino acid reductases differ from typical DHDHs, setting the stage for further engineering efforts to either enhance their catalytic efficiency or expand their substrate scopes.
The Generation, Evolution and Decay of Pure Quantum Turbulence: A Full Biot-Savart Simulation
Creators: name: Fujiyama, Shoji
name: Mitani, Akira
name: Tsubota, Makoto
name: Bradley, David I.
name: Fisher, Shaun N.
name: Guenault, Anthony M.
name: Haley, Richard P.
name: Pickett, George R.
name: Tsepelin, Viktor
Publisher: name: arXiv
Year: 2010
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: A zero temperature superfluid is arguably the simplest system in which to study complex fluid dynamics, such as turbulence. We describe computer simulations of such turbulence and compare the results directly with recent experiments in superfluid 3He-B. We are able to follow the entire process of the production, evolution, and decay of quantum turbulence. We find striking agreement between simulation and experiment and gain new insights into the mechanisms involved.
description: 5 pages, 4 figures, accepted for PRB Rapid Communications (11May2010)
Transition Complexity of Incomplete DFAs
Creators: name: Gao, Yuan
name: Salomaa, Kai
name: Yu, Sheng
Publisher: name: arXiv
Year: 2010
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: In this paper, we consider the transition complexity of regular languages based on the incomplete deterministic finite automata. A number of results on Boolean operations have been obtained. It is shown that the transition complexity results for union and complementation are very different from the state complexity results for the same operations. However, for intersection, the transition complexity result is similar to that of state complexity.
description: In Proceedings DCFS 2010, arXiv:1008.1270
Position of the acetabular cup -- accuracy of radiographic calculation compared to CT-based measurement
Creators: name: Kalteis, Thomas
name: Handel, Martin
name: Herold, Thomas
name: Perlick, Lars
name: Paetzel, Christian
name: Grifka, Joachim
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Hip arthroplasty; Acetabular cup; Anteversion; Inclination; Computer-assisted surgery
subject: 610 Medizin

description: OBJECTIVE: A variety of mathematical and trigonometric methods has been described for determining the position of the acetabular cups from conventional radiographs. However, these formulae are subject to unduly large inaccuracies. The aim of the study was to compare the reliability and the accuracy of radiological and CT-based determination of acetabular cup position. MATERIALS AND METHODS: The positions of acetabular cups of 31 patients were calculated in conventional plain radiographs of the hip using the method described by Widmer. Further, in all patients computed tomograms of the pelvis were performed and the cup position was measured with the aid of a CT-based computer-assisted navigation software. As reference values inclination and anteversion of the cups were calculated in 3D reconstructions of the pelvis with the aid of an image processing software. RESULTS: The radiological measurement as well as the CT-based method showed good intra- and inter-observer reliability and no significant difference in the calculation of the inclination (p=0.409). However, CT-based determination of anteversion was significantly more exact than radiological measurement (p<0.001). The calculation of the cup anteversion from the X-rays showed serious deviations from the reference method and a substantial error range (X-ray: mean deviation +1.74 degrees, range -16.6 degrees to +29.8 degrees , S.D. +/-9.32 degrees; CT-based: mean deviation -0.74 degrees, range -6.6 degrees to +5.3 degrees, S.D. +/-2.87). CONCLUSION: For any clinical problem or for clinical studies in which acetabular positions of acetabular cups have to be exactly determined, CT-based measuring methods are obviously the method of choice. Evaluations based only on conventional plain X-rays and calculation of the acetabular cup position using the formula described by Widmer must be regarded as unreliable, particularly, because of problems in measuring the anteversion.
title: Hyperspektral Imaging als modernes Tool im Wundmanagement und in der Infektionsdiagnostik
Creators: name: Daeschlein, Georg
name: von Podewils, Sebastian
name: Sicher, Claudia
name: Jünger, Michael
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Obwohl derzeit verschiedenste Bildgebungsverfahren zur Beurteilung der Mikrozirkulation von Wunden zur Verfügung stehen, mangelt es vielfach an der Erhebung parametrisierter standardisierter Perfusionsparameter wie an der praktischen Nutzbarkeit der Technik. Eine moderne Perfusionsdarstellung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
title: Fluoreszenzbildgebung in der Herzchirurgie – Integraler Bestandteil eines innovativen Wundkonzeptes
Creators: name: Rotering, Heinrich
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Wundinfektionen stellen auch in der Herzchirurgie für betroffene Patienten ein bislang nur unzureichend gelöstes Problem dar. Neben den zum Teil erheblich verlängerten, stationären Liegezeiten und den damit verbundenen zusätzlichen Behandlungskosten sind insbesondere die tiefen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
title: Kompression mit Zinkleim – Die Renaissance einer alten Technik?
Creators: name: Schmitz, Michael
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Die Kompression wird schon seit vielen Jahrhunderten zur Behandlung von Ödemen und anderen venösen und lymphatischen Erkrankungen der unteren Gliedmaßen angewendet. Durch die Anwendung der Kompression im angemessenen Umfang verringert sich der Durchmesser der großen Venen; dies ist[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
On triangular billiards
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D50

description: We prove a conjecture of Kenyon and Smillie concerning the nonexistence of acute rational-angled triangles with the lattice property.
The role of the microenvironment and inflammation in the promotion of cancer metastasis
Creators: name: Arif, Arif A.
Publisher: name: University of British Columbia
Year: 2021

description: Circulating tumor cells become fully metastatic if they are able to extravasate from the microvasculature and move into microenvironmental niches within distant site organs where they survive and proliferate. To determine if inflammation facilitates this process, models of inflammatory asthma, hypersensitivity pneumonitis, or bleomycin-induced injury were used, followed by introduction of B16F0 melanoma cells into the microvasculature of the lungs. Strikingly, all three conditions increased overt metastasis without increasing extravasation and the number and size of early metastases were increased. Bleomycin induced inflammation led to the increased survival of B16F0 tumor cells and recruitment of monocyte derived macrophages (MoDM) to the lungs. These MoDM were located near the micrometastatic niche and their presence correlated with increased metastatic tumor cell burden. Inflammation also increased the deposition of the ECM component hyaluronan (HA) in the lung stroma and it was enriched in B16F0 containing metastatic nodules. HA binding through its cognate receptor CD44 correlates with an increase in the metastatic potential of B16 melanoma cells. However, deletion of CD44 using CD44-/- mice or CD44-/- B16F0 cells did not affect inflammation-driven increases in metastasis. Chondroitin sulphate (CS) was found to negatively regulate HA binding in B16 cells, and CS-null CD44 constitutively bound high levels of HA unlike parental B16F0 cells. Thus, high HA binding may be required for effects on metastasis, or HA may be priming the inflammatory premetastatic niche in a CD44 independent manner. Taken together these findings illustrate the importance of the microenvironment in distant site metastasis and they highlight inflammation as an important modifier of this microenvironment.
Gaussian estimates for a heat equation on a network
Creators: name: Mugnolo, Delio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 47D06 (Primary), 47A07, 90B10 (Secondary)

description: We consider a diffusion problem on a network on whose nodes we impose Dirichlet and generalized, non-local Kirchhoff-type conditions. We prove well-posedness of the associated initial value problem, and we exploit the theory of sub-Markovian and ultracontractive semigroups in order to obtain upper Gaussian estimates for the integral kernel. We conclude that the same diffusion problem is governed by an analytic semigroup acting on all $L^p$-type spaces as well as on suitable spaces of continuous functions. Stability and spectral issues are also discussed. As an application we discuss a system of semilinear equations on a network related to potential transmission problems arising in neurobiology.
description: In comparison with the already published version of this paper (Netw. Het. Media 2 (2007), 55-79), a small gap in the proof of Proposition 3.2 has been filled
title: Intermittierende apparative Kompression
Creators: name: Ulbrich, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Die apparative Anwendung pneumatischer Wechseldrücke ist für viele Indikationen wie die Thromboseprophylaxe, zur Ulcustherapie sowie zur Therapie des Lymphödems mit einer vorhandenen Datenlage zugelassen und von verschiedenen Fachgesellschaften in verschiedenen Leitlinien empfohlen. Insbesondere[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
Creators: name: Gottfried, Eva
name: Kunz-Schughart, Leoni A.
name: Ebner, Stephanie
name: Mueller-Klieser, Wolfgang
name: Hoves, Sabine
name: Andreesen, Reinhard
name: Mackensen, Andreas
name: Kreutz, Marina
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: The tumor milieu can influence dendritic cell (DC) differentiation. We analyzed DC differentiation in a 3-dimensional tumor model and propose a new mechanism of DC modulation by the tumor environment. Monocytes were cultured in the presence of IL-4 and GM-CSF within multicellular tumor spheroids (MCTSs) generated from different tumor cell lines. Monocytes invaded the MCTSs and differentiated into tumor-associated dendritic cells (TADCs). The antigen expression was altered on TADCs independent of the culture conditions (immature/mature DCs, Langerhans cells) and IL-12 secretion was reduced. Supernatants of MCTSs could partially transfer the suppressive effect. Conditioned media from urothelial carcinoma cell lines contained high levels of M-CSF and IL-6, both cytokines known to modulate DC differentiation. In contrast, melanoma and prostate carcinoma MCTS cocultures produced little M-CSF and IL-6, but high levels of lactic acid. Indeed, addition of lactic acid during DC differentiation in vitro induced a phenotype comparable with TADCs generated within melanoma and prostate carcinoma MCTSs. Blocking of lactic acid production in melanoma MCTS cocultures reverted the TADC phenotype to normal. We therefore conclude that tumor-derived lactic acid is an important factor modulating the DC phenotype in the tumor environment, which may critically contribute to tumor escape mechanisms.