cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Clinical applications of Susceptibility Weighted Sequence in Neuroimaging at 3 Tesla
Creators: name: Singh, Bhanupriya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: MR
subject: Imaging sequences
subject: Image verification

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: SWI is high-spatial-resolution 3D gradient-echo MR imaging technique to enhance contrast by accentuating paramagnetic properties of blood product.Aim of this pictorial review is to outline basic physics of SWI and to describe different applications...
title: Pictorial essay of congenital fetal anomalies on antenatal sonography and MRI
Creators: name: Singh, Bhanupriya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Foetal imaging
subject: MR
subject: Screening
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Antenatal imaging is required to diagnose fetal abnormalities prior to delivery so that in utero interventions can be planned and post-delivery management of the infant can be...
(401550) Lilian Jane Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: MRI evaluation , classification and differential diagnosis of spinal tumors
Creators: name: Singh, Bhanupriya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology spine
subject: MR
subject: Contrast agent-intravenous
subject: Localisation
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To review the MRI findings of various spinal tumors. To classify the spinal tumors into extradural, intradural extramedullary and intradural intramedullary compartments. Discuss the differential diagnosis for tumors located in each...
title: Impact of the automatic exposure control system (AEC) on virtual monochromatic image quality for the Dual-source CT : A phantom study.
Creators: name: Dabli, Djamel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiation physics
subject: CT
subject: Physics
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To assess the impact of the automatic exposure control system on virtual monochromatic image quality in Dual-source...
(401546) Emily Elizabeth Sophia [Cator]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MathML
Creators: name: Hagen, Hans
Publisher: name: Humboldt-Universität zu Berlin
Year: 2003
Subjects: 01 Wissenschaft und Kultur allgemein

description: It is a well known fact that TeX can do a pretty good job on typesetting math. This is one reason why many scientific articles, papers and books are typeset using TeX. However, in these days of triumphing angle brackets, coding in TeX looks more and more out of place. From the point of view of an author, coding in TeX is quite natural, given that some time is spent on reading the manuals. This is because not only the natural flow of the definition suits the way mathematicians think, but also because the author has quite some control over the way his thoughts end up on paper. It will be no surprise that switching to a more restricted way of coding, which also demands more keystrokes, is not on forehand considered to be better. There are however circumstances that one wants to share formulas (or formula like specifications) between several applications, one of which is a typesetting engine. In that case, a bit more work now, later saves you some headaches due to keeping the different source documents in sync. As soon as coding math in angle brackets is discussed, those in favour stress that coding can be eased by using appropriate editors. Here we encounter a dilemma. For optimal usage, one should code in terms of content, that is, the principles that are expressed in a formula. Editors are not that strong in this area, and if they would be, editing would be not that much different from traditionally editing formulas: just keying in ideas using code that at first sight looks obscure. A more graphical oriented editor can help authors to compose formulas, but the under laying coding will mainly be in terms of placing glyphs and boxes, and as a result the code will hardly be usable in other applications. So either we code in terms of concepts, which permits sharing code among applications, and poses strong limitations on the influence of authors on the visual appearance. Or we use an interactive editor to fine tune the appearance of a formula and take for granted that reuse will be minimal or suboptimal. In this presentation I will discuss the mathematical language MathML in the perspective of current publishing workflows and high end typography. I will demonstrate how formulas coded in MathML can be transformed into readable output and discuss some of the limitations of the current definition of MathML.
(401547) Robert Crawford Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MyBib from Librarians for Librarians and library network
Creators: name: Rasche, Rolf
Publisher: name: Humboldt-Universität zu Berlin
Year: 2003
Subjects: 01 Wissenschaft und Kultur allgemein

description: Electronic theses and dissertation are the topic of the ETD, but what about all the theses, which are not yet electronically published and only available on paper or even worse on microfilm? As the manufacturer of the Bookeye® family of scanners we have had a lot of discussions with libraries and their needs. One topic was the gap between the increasing demand for electronic availability of documents like dissertations and theses and their real availability on paper or microfilm. To close this gap - besides others like electronic document delivery via ILL and/or an alternative to ARIEL - we were asked to develop an open WEB-based system together with librarians. The development guidelines were a browser-based user interface, usage of PHP, Apache, MySQL, and the system should run on Windows and Linux. The result was Mybib, a platform to cover: * electronic document delivery * scan on demand applications, as an alternative to scanning entire stocks * back file conversion to supply extended OPAC´s Requests for documents to be scanned and delivered can be issued to Mybib by any library system, OPAC or free style WEB-form via ILL, XML or E-Mail. The whole process from the incoming request, through scanning to the delivery is cov-ered by Mybib. Modules for tracking, billing, claim handling, statistics and others support the management and supervisor of the library. MyBib is scalable from one to many scanning, operation and management workplaces. It covers the needs of big libraries located in one place, as well as libraries with departments located in different places. And all of them can be supervised from one place anywhere in the world via Internet or VPN with a Browser To get theses and documents from paper/microfilm to a digital form, they have to be scanned, which is realized by the My-Bib Scan-client. It covers overhead-, flatbed-, autofeed- and microfilm- scanners as well as digital copier systems from RICOH, CANON and others, which can be used as scanner and printer. And if the scanner supports color or formats up to A1 (34" by 22"), Mybib supports it too. Last, but not least there is the question of intellectual property rights. To help protect these rights, the electronic endorser in Mybib imprints a digital watermark as proof of information supplier or copyright remarks with time stamp in the delivered documents.
Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function
Creators: name: Keogh, Michael Christopher
name: Fillingham, Jeffrey S.
name: Bouhassira, Eric E.
name: Greenblatt, Jack F.
name: Ryan, Colm J.
name: Silva, Andrea C.
name: Strahl, Brian D.
name: Kim, Hyun Soo
name: Hardwick, Kevin G.
name: Xu, Jiewei
name: Kislinger, Thomas
name: Rothbart, Scott B.
name: Mukhopadhyay, Rituparna
name: Vanoosthuyse, Vincent
name: Krogan, Nevan J.
name: Edelmann, Winfried
name: Jahari, Harlizawati
name: Roguev, Assen
name: Radovani, Ernest
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Condensin is a central regulator of mitotic genome structure, with mutants showing poorly condensed chromosomes and profound segregation defects. Here we identify NCT complex, comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), Casein Kinase II (CKII) and several TAFs, as a regulator of condensin function. We show that NCT and condensin bind similar genomic regions, but only briefly co-localize during the periods of chromosome condensation and decondensation. This pattern of NCT binding at the core centromere, the region of maximal condensin enrichment, tracks the abundance of acetylated histone H4, as regulated by the Hat1-Mis16 acetyltransferase complex and recognized by the first Nrc1 bromodomain. Strikingly, mutants in NCT or Hat1-Mis16 restore the formation of segregation-competent chromosomes in cells containing defective condensin. These results are consistent with a model where NCT targets CKII to chromatin in a cell cycle-directed manner to modulate the activity of condensin during chromosome condensation and decondensation.
title: A convolutional neural network approach for automated quantification of emphysema and fibrosis in idiopathic interstitial pneumonia (IIP)
Creators: name: Brüggenwerth, Günther
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT-High Resolution
subject: Computer Applications-Detection, diagnosis
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Purpose Idiopathic interstitial pneumonia (IIP) is a condition comprising specific patterns of pulmonary fibrosis and emphysema. The exact prevalence is not fully known, due to differences between studies, lack of key features when examined, or...
CAREER TECHNICAL EDUCATION ONLINE VERSUS FACE-TO-FACE
Creators: name: Fernandez, Margaret
Publisher: name: Zenodo
Year: 2023
Subjects: career technical education
online
face-to-face

description: Career and technical education's (CTE) role in preparing tomorrow's workforce to meet the growing demands for middle-skilled workers with industry-valued degrees and certificates is critical to the mission of higher education and a conduit for class mobility for some communities. Given the burgeoning demands of today's workforce and dwindling enrollments, a strategic shift towards online education emerges as a compelling solution, despite educators' concerns regarding perceived discrepancies in student success. This study used an explanatory sequential mixed methods approach, melding quantitative and qualitative data from a community college automotive program and scrutinizing the impacts of in-person and online course delivery modalities on student success. The findings revealed that students in Automotive online (M = 3.35, SD = 1.062) courses had higher average grades than traditional face-to-face students (M = 2.82, SD = 1.221). However, no discernible correlation emerged between the course format and completion or withdrawal rates. A thematic dissection of student experiences identifies pivotal factors driving online learning success: course content, instructional quality, and technology support. In response to these findings, the study outlines crucial strategies such as augmenting online support services like academic counseling, bolstering faculty-student communication through techniques such as virtual office hours, hybrid options, and fine-tuning online course design with hands-on experiences at its core. This study underscores the necessity for additional empirical research in online CTE courses to streamline the transition from hands-on to online skill-building learning.
Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis
Creators: name: Spandau, Dan F.
name: Zhang, Xin
name: Hertzler-Schaefer, Kristina
name: Chen, Yiping
name: Somani, Ally Khan
name: Tholpady, Sunil
name: Mathew, Grinu
name: Kadakia, Madhavi P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational activation of Fgf10 by Pten deletion is reversed by genetic disruption of the mTORC1 complex, which also prevents skin tumorigenesis in Pten mutants. We further show that ectopic expression of Fgf10 causes skin papillomas, while Pten deletion-induced skin tumors are inhibited by epidermal deletion of Fgfr2. Collectively, our data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors.
Humboldt University Media Portal: Workspace and Archive
Creators: name: Vollmer, Andreas
Publisher: name: Humboldt-Universität zu Berlin
Year: 2003
Subjects: 01 Wissenschaft und Kultur allgemein

description: Many academic materials are already available in digital format or will soon be digitized. They are handled in countless workflows and storage-procedures all over the campus, in most cases only accessible by their author. Every-day knowledge of all kinds emerges, rapidly vanishing into depths of unknown hard disks or CD-ROMs. Both the flood of sparsely organized digital documents and electronic amnesia increasingly become a problem to be managed by academic institutions. Humboldt University aims to offer scientists and students a new tool for storage, organization, and work with multimedia contents. This media portal should be suitable for both daily work and long term archiving by mouse click, if desired. Storage and reuse should be easy and work for different document types and for single materials as collections of any size and academic genre. All public materials can be browsed across campus and worldwide and form a growing database and historical archive of research. Goals: The basic working system will be further developed in a couple of steps within the framework of last year's program and evaluation of open testing. The project is coordinated by the Multimedia Support Centre for Teachers and Researchers (MLZ) and merges expertise from the Humboldt University document server (international metadata-standards, long term archiving), software from Zweitwerk and Nionex (asset management) and aims to integrate asset brokerage with learning management. The presentation will discuss some of the main aspects in planning and building the media portal for Humboldt University.
Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants
Creators: name: Ahmed, Shawn
name: Mitchell, Jacinth
name: Simon, Matt
name: Sarkies, Peter
name: Doebley, Anna Lisa
name: Miska, Eric A.
name: Ikegami, Kohta
name: Goldstein, Leonard D.
name: Sakaguchi, Aisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Defects in the Piwi/piRNA pathway lead to transposon desilencing and immediate sterility in many organisms. We found that the C. elegans Piwi mutant prg-1 became sterile after growth for many generations. This phenotype did not occur for RNA interference mutants with strong transposon silencing defects and was separable from the role of PRG-1 in transgene silencing. Brief periods of starvation extended the transgenerational lifespan of prg-1 mutants by stimulating the DAF-16/FOXO longevity transcription factor. Constitutive activation of DAF-16 via reduced daf-2 insulin/IGF-1 signaling immortalized prg-1 strains via RNA interference proteins and histone H3 lysine 4 demethylases. In late-generation prg-1 mutants, desilencing of repetitive segments of the genome occurred, and silencing of repetitive loci was restored in prg-1; daf-2 mutants. This study reveals an unexpected interface between aging and transgenerational maintenance of germ cells, where somatic longevity is coupled to a genome silencing pathway that promotes germ cell immortality in parallel to the Piwi/piRNA system.
title: Role of imaging in the diagnosis of splenosis
Creators: name: Visalli, Gianluca
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: CT
subject: MR
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Education
subject: Education and training
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To illustrate the radiological features of splenosis and to simplify the differential diagnosis with other...
The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers
Creators: name: Peng, Danni
name: Bentley, David L.
name: Groudine, Mark
name: Zhang, Xi
name: Wen, Hong
name: Peña, Pedro V.
name: Larson, Connie
name: Zheng, Xia
name: Xi, Yuanxin
name: Mangan, Anthony
name: Li, Wei
name: Kutateladze, Tatiana G.
name: Klein, Brianna J.
name: Shi, Xiaobing
name: Strahl, Brian D.
name: Rothbart, Scott B.
name: Cortazar, Michael A.
name: Piao, Lianhua
name: Rincon-Arano, Hector
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation. It contains three PHD fingers, the biological roles of which remain elusive. Here, we show that the first PHD1 finger of KDM5B binds unmodified histone H3, whereas the third PHD3 finger prefers the trimethylated mark, H3K4me3. RNA-seq analysis indicates that KDM5B functions as a transcriptional repressor for a set of genes. Biochemical analysis reveals that KDM5B associates with components of the nucleosome remodeling and deacetylase (NuRD) complex and may cooperate with HDAC1 in gene repression. Compared with the estrogen receptor positive breast cancers, KDM5B is downregulated in the triple-negative breast cancer. Overexpression of KDM5B in the MDA-MB 231 breast cancer cells suppresses cell migration and invasion ability, and the PHD1-H3K4me0 interaction is important for inhibition of migration. These findings highlight tumor-suppressive functions of KDM5B in triple-negative breast cancer cells and suggest a novel multivalent mechanism for KDM5B-mediated transcriptional regulation.
A SISTEMATIZAÇÃO DA ASSISTÊNCIA EM ENFERMAGEM UTILIZANDO O RT CONNECT EM UM SERVIÇO DE RADIOTERAPIA DO ESTADO DE SANTA CATARINA
Creators: name: Ribeiro, G
name: Thiago, E. L. S
name: Huhn, A.
name: Queiroz, C
name: Piedade, P. A.
name: Souza, D. C. B.
name: Fagundes, M. E.
Publisher: name: Zenodo
Year: 2022
Subjects: SAE Enfermagem
SAE RADIOTERAPIA
SAE

description: A SAE, Sistematização da Assistência de Enfermagem, requer a implementação da tecnologia eficaz, e sua utilização no serviço do gerenciamento operacional integrado às ações da enfermagem em radioterapia, é cada vez mais necessário. A tecnologia da informação está cada vez mais presente, e em crescimento expressivo, no setor saúde. O trabalho em saúde deve ser tratado ao nível de expectativa, relevância e magnitude que a saúde representa para a sociedade e indivíduo. Um prestador de serviço em saúde é visto como uma entidade transformadora, que utiliza recursos físicos, humanos e tecnológicos de que dispõe, ou obtém, para produzir os serviços que são entregues aos usuários, tornando os sistemas de gestão de qualidade e de melhoria contínua. Mais Informações: http://rtmedical.com.br/
Graviton time delay and a speed limit for small black holes in Einstein-Gauss-Bonnet theory
Creators: name: Papallo, Giuseppe
name: Reall, Harvey S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Camanho, Edelstein, Maldacena and Zhiboedov have shown that gravitons can experience a negative Shapiro time delay, i.e. a time advance, in Einstein-Gauss-Bonnet theory. They studied gravitons propagating in singular "shock-wave" geometries. We study this effect for gravitons propagating in smooth black hole spacetimes. For a small enough black hole, we find that gravitons of appropriate polarisation, and small impact parameter, can experience time advance. Such gravitons can also exhibit a deflection angle less than $π$, characteristic of a repulsive short-distance gravitational interaction. We discuss problems with the suggestion that the time advance can be used to build a "time machine". In particular, we argue that a small black hole cannot be boosted to a speed arbitrarily close to the speed of light, as would be required in such a construction.
description: v2: Typos corrected. Short argument for time advance added in section 4.4. Added reference. Matches the version to appear in JHEP. 22 pages + appendices, 15 figures
Supplemental Material for Statistical study and parallelisation of multiplexed single-electron sources
Creators: name: Norimoto, Shota
name: See, Patrick
name: Schoinas, Nicholaos
name: Rungger, Ivan
name: Boykin II, Tommy
name: Stewart, Jr., Michael
name: Griffiths, J. P.
name: Chen, Chong
name: Ritchie, David
name: Kataoka, Masaya
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Supplemental Material for Statistical study and parallelisation of multiplexed single-electron sources
title: Is that blood? - Hemoperitoneum: Main CT findings
Creators: name: Grilo, Francisco
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Emergency
subject: Trauma
subject: CT
subject: Diagnostic procedure
subject: Blood
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Review the most common causes of hemoperitoneum and illustrate the main imaging...
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1
Creators: name: Strahl, Brian D.
name: Li, Lin
name: Wang, Yinsheng
name: Song, Jikui
name: Allison, David F.
name: Rothbart, Scott B.
name: Zhang, Zhi Min
name: Cai, Qian
name: Harrison, Joseph S.
name: Wang, Gang Greg
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The protein stability and chromatin functions of UHRF1 (Ubiquitin-like, containing PHD and RING Finger domains, 1) are regulated in a cell cycle-dependent manner. We report a structural characterization of the complex between UHRF1 and the deubiquitinase USP7. The first two UBL domains of USP7 bind to the polybasic region (PBR) of UHRF1, and this interaction is required for the USP7-mediated deubiquitination of UHRF1. Importantly, we find that the USP7-binding site of UHRF1 PBR overlaps with the region engaging an intramolecular interaction with the N-terminal tandem Tudor domain (TTD). We show that the USP7-UHRF1 interaction perturbs the TTD-PBR interaction of UHRF1, thereby shifting the conformation of UHRF1 from a TTD-“occluded” state to a state open for multivalent histone binding. Consistently, introduction of an USP7-interaction defective mutation to UHRF1 significantly reduces its chromatin association. Together, these results link USP7 interaction to the dynamic deubiquitination and chromatin association of UHRF1.
Neutron drip transition in accreting and nonaccreting neutron star crusts
Creators: name: Chamel, N.
name: Fantina, A. F.
name: Zdunik, J. L.
name: Haensel, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The neutron-drip transition in the dense matter constituting the interior of neutron stars generally refers to the appearance of unbound neutrons as the matter density reaches some threshold density $ρ_\textrm{drip}$. This transition has been mainly studied under the cold catalyzed matter hypothesis. However, this assumption is unrealistic for accreting neutron stars. After examining the physical processes that are thought to be allowed in both accreting and nonaccreting neutron stars, suitable conditions for the onset of neutron drip are derived and general analytical expressions for the neutron drip density and pressure are obtained. Moreover, we show that the neutron-drip transition occurs at lower density and pressure than those predicted within the mean-nucleus approximation. This transition is studied numerically for various initial composition of the ashes from X-ray bursts and superbursts using microscopic nuclear mass models.
description: 24 pages, accepted for publication in Physical Review C
(401543) John Robertson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Mediastinal complications in patients undergoing non-surgical lung cancer treatment
Creators: name: Gómez de Segura, Maider
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Mediastinum
subject: Thorax
subject: CT
subject: Fluoroscopy
subject: Contrast agent-intravenous
subject: Cancer
subject: Fistula

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describe the mediastinal complications in patients undergoing non-surgical lung cancer treatment and review the different possible causes. Show the most accurate imaging tests, as well as the most featured radiological findings, highlighting the...
Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy
Creators: name: Bauersachs, Stefan
name: Mazur, Erik C.
name: Grützner, Frank
name: Lieb, Jason D.
name: Feschotte, Cédric
name: Emera, Deena
name: Brayer, Kathryn
name: Sheikh, Shehzad Z.
name: Lynch, Vincent J.
name: DeMayo, Francesco J.
name: Wagner, Günter P.
name: Plaza, Silvia L.
name: Young, Steven L.
name: Nnamani, Mauris C.
name: Kapusta, Aurélie
name: Graf, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SUMMARYA major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the transition from egg laying to live birth. To determine the molecular bases of this transition, we characterized the pregnant/gravid uterine transcriptome from tetrapods to trace the evolutionary history of uterine gene expression. We show that thousands of genes evolved endometrial expression during the origins of mammalian pregnancy, including genes that mediate maternal-fetal communication and immunotolerance. Furthermore, thousands of cis-regulatory elements that mediate decidualization and cell-type identity in decidualized stromal cells are derived from ancient mammalian transposable elements (TEs). Our results indicate that one of the defining mammalian novelties evolved from DNA sequences derived from ancient mammalian TEs coopted into hormone-responsive regulatory elements distributed throughout the genome.Graphical abstract
Thermodynamic Identities and Symmetry Breaking in Short-Range Spin Glasses
Creators: name: Arguin, L. -P.
name: Newman, C. M.
name: Stein, D. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We present a technique to generate relations connecting pure state weights, overlaps, and correlation functions in short-range spin glasses. These are obtained directly from the unperturbed Hamiltonian and hold for general coupling distributions. All are satisfied in phases with simple thermodynamic structure, such as the droplet-scaling and chaotic pairs pictures. If instead nontrivial mixed-state pictures hold, the relations suggest that replica symmetry is broken as described by a Derrida-Ruelle cascade, with pure state weights distributed as a Poisson-Dirichlet process.
description: 6 pages in main text plus a 3-page supplement
(401545) Charles Frederick Cator
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
Creators: name: Vanhoutvin, Tine
name: López-Bendito, Guillermina
name: Demyanenko, Galina
name: Schachner, Melitta
name: Munck, Sebastian
name: De Strooper, Bart
name: Gärtner, Annette
name: Barão, Soraia
name: Maness, Patricia F.
name: Zhou, Lujia
name: Leyva-Díaz, Eduardo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SummaryBACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in thalamic and hippocampal neurons. An active membrane-bound proteolytic CHL1 fragment is generated by BACE1 upon Sema3A binding. This fragment relays the Sema3A signal via ezrin-radixin-moesin (ERM) proteins to the neuronal cytoskeleton. APH1B-γ-secretase-mediated degradation of this fragment stops the Sema3A-induced collapse and sensitizes the growth cone for the next axonal guidance cue. Thus, we reveal a cycle of proteolytic activity underlying growth cone collapse and restoration used by axons to find their correct trajectory in the brain. Our data also suggest that BACE1 and γ-secretase inhibition have physiologically opposite effects in this process, supporting the idea that combination therapy might attenuate some of the side effects associated with these drugs.Graphical abstract
(401540) Magda [Baxter]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Who is the best radiologist? Rapmed.net is a platform for competitions in diagnostic imaging.
Creators: name: Henkel, Maurice
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: Thorax
subject: Conventional radiography
subject: CT
subject: MR
subject: Computer Applications-Teleradiology
subject: Education
subject: eLearning
subject: Workforce

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Labelled image data is a rare good since it is not created in clinical routine [1]. Large volumes of labelled image data are required for the development of machine learning algorithms. The manual creation of labels for training algorithms is...
title: SEIS raw data, Insight Mission
Creators: name: InSight Mars SEIS Data Service
Publisher: name: IPGP, JPL, CNES, ETHZ, ICL, MPS, ISAE-Supaero, LPG, MFSC
Year: 2019
Subjects: subject: FDSN Temporary Network Code XB (2016-2022)

description: The NASA InSight mission deployed onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument shortly after its landing on November, 26, 2018; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data are transmitted in the form of continuous VBB and SP components and are augmented by requested event data with higher sampling rate. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ~2500 at 1 Hz and ~200000 at 0.1 Hz. Contrary to Viking, the seismometer has been deployed via a robotic arm directly onto Mars' surface and is protected against temperature and wind by highly efficient thermal and wind shielding. Very low noise has therefore been obtained, especially during the night by the VBB instrument. These data consist of all SEIS data, including the House Keeping data requested to monitor the instrument health.
title: Radiogenomics of Pancreatic Ductal AdenoCarcinoma
Creators: name: Geraci, Luca
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: Oncology
subject: Pancreas
subject: CT
subject: MR
subject: Experimental investigations
subject: Outcomes analysis
subject: Radiobiology
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Pancreatic cancer has a very poor prognosis and its most frequent isotype is represented by pancreatic ductal adenocarcinoma (PDAC). Despite advances in early diagnosis and multimodal treatments, the prognosis for patients with PDAC remains poor,...
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains
Creators: name: Granger, Deborah A.
name: Zawistowski, Jon S.
name: Carey, Lisa A.
name: Reuther, Rachel A.
name: Nakamura, Kazuhiro
name: Angus, Steven P.
name: Parker, Joel S.
name: Johnson, Gary L.
name: Sciaky, Noah
name: Jin, Jian
name: Collins, Kyla A.L.
name: Beltran, Adriana S.
name: Chen, Xin
name: Graves, Lee M.
name: Stuhlmiller, Timothy J.
name: Duncan, James S.
name: Gomez, Shawn M.
name: Kuan, Pei Fen
name: Earp, H. Shelton
name: Miller, Samantha M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Therapeutics such as lapatinib that target ERBB2 often provide initial clinical benefit but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogramming of the kinome through reactivation of ERBB2/ERBB3 signaling and transcriptional upregulation and activation of multiple tyrosine kinases. The heterogeneity of induced kinases prevents their targeting by a single kinase inhibitor, underscoring the challenge of predicting effective kinase inhibitor combination therapies. We hypothesized that to make the tumor response to single kinase inhibitors durable, the adaptive kinome response itself must be inhibited. Genetic and chemical inhibition of BET bromodomain chromatin readers suppresses transcription of many lapatinib-induced kinases involved in resistance including ERBB3, IGF1R, DDR1, MET, and FGFRs, preventing downstream SRC/FAK signaling and AKT reactivation. Combining inhibitors of kinases and chromatin readers prevents kinome adaptation by blocking transcription, generating a durable response to lapatinib and overcoming the dilemma of heterogeneity in the adaptive response.
(401541) Gertrude [Alice/Agnes?] Baxter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transparent boundary conditions for time-dependent electron transport in the R-matrix method with applications to nanostructured interfaces
Creators: name: Nemnes, G. A.
name: Palici, Alexandra
name: Manolescu, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Transparent boundary conditions for the time-dependent Schrodinger equation are implemented using the R-matrix method. The employed scattering formalism is suitable for describing open quantum systems and provides the framework for the time-dependent coherent transport. Transmission and reflection of wave functions at the edges of a finite quantum system are essential for an accurate and efficient description of the time-dependent processes on large time scales. The approach is used here to describe time-dependent transport across nanostructured interfaces relevant for photovoltaic applications.
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes  IDH  Mutant Cells to Alkylating Agents
Creators: name: Ma, Shenghong
name: Ye, Dan
name: Hoadley, Katherine A.
name: Perou, Charles M.
name: Zhang, Lei
name: Wu, Jing
name: Wilkerson, Matthew D.
name: Wang, Pu
name: Xiong, Yue
name: Yao, Jun
name: Guan, Kun Liang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients. The benefit of this regimen, known as PCV, was recently linked to IDH mutation that occurs frequently in glioma and produces D-2-hydroxyglutarate (D-2-HG), a competitive inhibitor of α-ketoglutarate (α-KG). We report here that D-2-HG inhibits the α-KG-dependent alkB homolog (ALKBH) DNA repair enzymes. Cells expressing mutant IDH display reduced repair kinetics, accumulate more DNA damages, and are sensitized to alkylating agents. The observed sensitization to alkylating agents requires the catalytic activity of mutant IDH to produce D-2-HG and can be reversed by the deletion of mutant IDH allele or overexpression of ALKBH2 or AKLBH3. Our results suggest that impairment of DNA repair may contribute to tumorigenesis driven by IDH mutations and that alkylating agents may merit exploration for treating IDH-mutated cancer patients.
title: Quantitative assessment of pancreatic cysts – a preliminary study
Creators: name: Young, Liam
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Biliary Tract / Gallbladder
subject: Pancreas
subject: MR-Cholangiography
subject: Cholangiography
subject: Cysts

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Pancreatic cysts are typically asymptomatic and are observed in 3%-15% of patients undergoing routine abdominal imaging, with prevalence increasing with age.[1,2] These pancreatic lesions can be sub-divided into two major groups according to...
Shortcuts to adiabaticity from linear response theory
Creators: name: Acconcia, Thiago V.
name: Bonança, Marcus V. S.
name: Deffner, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A shortcut to adiabaticity is a finite-time process that produces the same final state as would result from infinitely slow driving. We show that such shortcuts can be found for weak perturbations from linear response theory. With the help of phenomenological response functions a simple expression for the excess work is found -- quantifying the nonequilibrium excitations. For two specific examples, the quantum parametric oscillator and the spin-1/2 in a time-dependent magnetic field, we show that finite-time zeros of the excess work indicate the existence of shortcuts. Finally, we propose a degenerate family of protocols, which facilitate shortcuts to adiabaticity for specific and very short driving times.
description: 9 pages, 8 figure; published version
title: Pulmonary artery aneurysms and pseudo aneurysms: a rare but potentially fatal finding
Creators: name: souissi, ines
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Lung
subject: Pulmonary vessels
subject: CT
subject: CT-Angiography
subject: Embolisation
subject: Aneurysms
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review and illustrate the pulmonary vascular anatomy. To describe and illustrate the radiologic manifestations of pulmonary artery aneurysms and pseudoaneurysms. To overview the different aetiologies of pulmonary artery aneurysms and...
Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity
Creators: name: Griffith, Jack D.
name: Takeda, Shunichi
name: Dutta, Anindya
name: Shibata, Yoshiyuki
name: Wang, Yuh Hwa
name: Pommier, Yves
name: Dillon, Laura W.
name: Willcox, Smaranda
name: Kumar, Pankaj
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: MicroDNAs are <400-base extrachromosomal circles found in mammalian cells. Tens of thousands of microDNAs have been found in all tissue types, including sperm. MicroDNAs arise preferentially from areas with high gene density, GC content, and exon density, from promoters with activating chromatin modifications and in sperm from the 5'-UTR of full-length LINE-1 elements, but are depleted from lamin-associated heterochromatin. Analysis of microDNAs from a set of human cancer cell lines revealed lineage-specific patterns of microDNA origins. A survey of microDNAs from chicken cells defective in various DNA repair proteins reveal that homologous recombination and nonhomologous end joining repair pathways are not required for microDNA production. Deletion of the MSH3 DNA mismatch repair protein results in a significant decrease in microDNA abundance, specifically from non-CpG genomic regions. Thus, microDNAs arise as part of normal cellular physiology; either from DNA breaks associated with RNA metabolism or from replication slippage followed by mismatch repair.
(401542) John James Robertson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.