cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung Nr. 23522.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.12.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Total parenteral nutrition alters hepatic drug conjugation in rats
Creators: name: Raftogianis, Rebecca Blanchard
Publisher: name: University of Utah
Year: 2012
Subjects: Prostaglandin
Glutathione

description: Total parenteral nutrition (TPN) provides complete nutritional support in settings in which patients cannot eat. TPN, typically administered through a central vein as an elemental nutrient solution, bypasses the intestinal tract and causes adverse effects to the gut and liver. TPN has also been shown to depress hepatic drug oxidation, but its effects on drug conjugation have not been characterized. The purpose of this research was to examine the effects of TPN on hepatic drug conjugation in male Sprague Dawley rats and to investigate the role of such factors as the composition of TPN solutions and the route of administration in contributing to alterations in hepatic drug metabolism. Results confirm that TPN depresses hepatic drug oxidation and further indicate that TPN diminishes the in vitro rate of hepatic conjugation reactions and decreases the total clearance of acetaminophen in vivo due to decreased formation of the sulfate metabolite. These changes occur independently of parenteral route of administration (portal vein vs. inferior vena cava) and may linger for greater than one week after normal feeding has been resumed. Substituting 25% of the nonprotein calories with lipid similarly alters drug metabolism. When the TPN solution is administered enterally, however, hepatic drug metabolism is unaffected compared to chow fed animals. These investigations suggest that intestinal physiology is an important regulator of hepatic drug metabolism.
Stereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo
Creators: name: Yin, Li-Na
name: Zhang, Ya-Wen
name: Huang, Wen-Hai
name: Wang, Sheng-Hao
name: Zheng, Gao-Li
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The influence of chiral excipient D-chitosan (CS) on the stereoselective release of racemic ketoprofen (rac-KET) microspheres has been investigated in comparison to those microspheres containing individual enantiomers in vitro and in vivo. Stereoselectivity was observed in vitro release test, with R-KET release slightly higher than that of S-KET, especially in 3% rac-KET loading microspheres. Stereoselectivity is dependent on the content of chiral excipient and pH of release medium. A molecular docking study between CS and KET enantiomers further revealed that S-KET has a stronger interaction with CS compared to R-KET. Moreover, the plasma concentration of KET enantiomers in rats shows substantial differences, as the plasma levels of S-KET were higher than those of R-KET. Plasma levels of enantiomers from the R-KET microspheres had similar stereoselectivity as rac-KET microspheres. The S/R ratio of rac-KET microspheres was significantly lower than that of rac-KET suspension (regular-release formulation) (p<.05), and the differences is 3–5 fold. Besides, rates of R-KET converted to S-KET exhibited differences between rac-KET microspheres and suspension. Similar results were also found between R-KET microspheres and suspension. All investigations suggest that the chitosan interacting preferentially with S-KET to R-KET significantly affect the stereoselective pharmacokinetics of rac-KET from chitosan microspheres in rats.
Sonnenfleckenzeichnung Nr. 23427.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Effect of a multidimensional weight management program for children
Creators: name: Page, Allison J.
Publisher: name: University of Utah
Year: 2012
Subjects: Diet Therapy

description: Childhood obesity is a multifactorial problem with an undefined etiology.  Environment and hereditary links have been made, but the exact cause remains to be discovered.  Until a genetic basis and form of genetic intervention are discovered, the environmental influences will remain the target of treatment.   Current research focuses on the obese person's environment since the variables are recognizable and often controllable.  The most successful form of intervention to date is behavior modification.  The weight maintenance results are as discouraging for children as they are for adults, with a failure rate of approximately 98%. Current literature suggests combining treatment approaches, such as behavior therapy, exercise, family participation, and follow-up.  This study attempted to determine the effectiveness of a multidimensional family-oriented weight management program for children.  Eight families attended a 10-week program, along with follow-up home visits, 1 and 3 months after the end of the class.  The entire study lasted 6 months.  A control group was recruited, retrospectively, to compare their weight and height changes with the intervention group over a 6 month period.  The results revealed a weight maintenance for the intervention group during the 10-week program, with a decrease in percent over ideal weight after 6 months.  The controls demonstrated an unpredictable course of weight gain, with an actual increase in the group's percent over ideal weight for height.  The small sample size and method of control group data collection may have contributed to the lack of statistical significance.  The difference between the two groups was not statistically significant (p=.06) according to a 2-tailed independent sample t-test.  A nonparametric median test was performed and also did not demonstrate statistical significance at the probability level of p = .05.  These results strongly suggest difference between the two groups, and that the intervention was successful in altering the children's lifestyle habits which contributed to their excess weight.
Sonnenfleckenzeichnung Nr. 23452.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23391.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23352.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23500.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.11.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Celulite Inguinal Como Manifestação de Infeção Tardia por Streptococcus do Grupo B
Creators: name: Ferreira, Joana
name: Alves, Marta
name: Santalha, Marta
name: Ferreira, Cristina
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: O Streptococcus do grupo B é considerado um dos principais agentes de infeção perinatal, tanto precoce como tardia, e pode ser responsável por um amplo espetro de doença sistémica ou localizada. Apresenta-se o caso clínico de uma lactente com 4 semanas de idade, previamente saudável, com celulite de localização inguinal associada a bacteriemia por Streptococcus do grupo B e discutem-se a apresentação clínica, as alterações nos exames complementares de diagnóstico e a evolução desta entidade clínica, com base numa revisão da literatura. O caso apresentado destaca a celulite como uma forma de apresentação rara de infeção tardia por Streptococcus do grupo B, demonstrando que pode ser o único marcador de doença invasiva em crianças saudáveis.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23536.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.12.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Streptococcal pharyngitis : what do parents know?
Creators: name: Hillard, Sharon K.
Publisher: name: University of Utah
Year: 2012
Subjects: Patient Compliance
Pediatric Nursing

description: This study sought to determine the level of parental knowledge regarding Streptococcal pharyngitis (strep throat).  The sample was composed of 100 parents of children who visited the Willow Creek and the University of Utah Pediatric practices.  At each site, parents were asked to provide demographic data and respond to a questionnaire which focused on the treatment, susceptibility and diagnostic aspects of strep throat.  Parents scored highest on questions concerning treatment (87%).  Seventy-five percent of the questions on susceptibility were answered correctly.  Parents scored lowest on questions about diagnosis (68%).  The leading source of knowledge about strep throat for parents was prior experience with the disease (63%).  A low correlation was noted between income level and education versus correct answers.  No correlation existed with other demographic variables and knowledge base.  The study also evaluated whether a difference existed between what parent know and what health care providers believe parents need to know regarding Streptococcal pharyngitis.  A difference was found to exist on certain questions within the categories of treatment, susceptibility and diagnosis.
Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway
Creators: name: Menshawe, Shahira F. El
name: Nafady, Mohamed M.
name: Aboud, Heba M.
name: Kharshoum, Rasha M.
name: Elkelawy, Asmaa Mohammed M. Hussein
name: Hamad, Doaa S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: The current study aimed to encapsulate fluvastatin sodium (FVS), a member of the statins family possessing pleiotropic effects in rheumatoid arthritis (RA), into spanlastic nanovesicles (SNVs) for transdermal delivery. This novel delivery could surmount FVS associated oral encumbrances such as apparent first-pass effect, poor bioavailability and short elimination half-life, hence, accomplishing platform for management of RA. To consummate this objective, FVS-loaded SNVs were elaborated by thin film hydration method, utilizing either Span 60 or Span 80, together with Tween 80 or Brij 35 as an edge activator according to full factorial design (24). Applying Design-Expert® software, the influence of formulation variables on SNVs physicochemical properties and the optimized formulation selection were explored. Additionally, the pharmacokinetic studies were scrutinized in rats. Furthermore, in Freund's adjuvant-induced arthritis, rheumatoid markers, TNF-α, IL-10, p38 MAPK, and antioxidant parameters were measured. The optimum SNVs were nano-scaled spherical vesicles (201.54 ± 9.16 nm), having reasonable entrapment efficiency (71.28 ± 2.05%), appropriate release over 8 h (89.45 ± 3.64%) and adequate permeation characteristics across the skin (402.55 ± 27.48 µg/cm2). The pharmacokinetic study disclosed ameliorated bioavailability of the optimum SNVs gel by 2.79- and 4.59-fold as compared to the oral solution as well as the traditional gel, respectively. Moreover, it elicited a significant suppression of p38 MAPK expression and also significant improvement of all other measured biomarkers. Concisely, the foregoing findings proposed that SNVs can be auspicious for augmenting FVS transdermal delivery for management of RA.
Sonnenfleckenzeichnung Nr. 23512.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.11.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23484.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23356.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Apendicectomia Precoce ou Diferida no Fleimão ou Abcesso Apendicular
Creators: name: Morgado, Mariana
name: Gonçalves, Miroslava
name: Fernandes, Ricardo M
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23415.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Hydrodynamics of axial-flow and centrifugal-flow left ventricular assist devices
Creators: name: Stanfield, James Ryan
Publisher: name: University of Utah
Year: 2012
Subjects: Hydrodynamics
Mechanical circulatory support
Pressure sensitivity
Pulsatility
Rotary blood pump
Ventricular assist device

description: Heart disease is the leading cause of death in the United States. Mechanical circulatory support by ventricular assist devices (VADs) is a means by which deteriorating heart function can be supplemented, and is a leading therapy for latestage heart failure patients. The devices are commonly connected to the apex of the  left ventricle (LV) to move oxygenated blood to the body via the aorta. Recent developments have made continuous-flow pumps commonplace in the clinical  environment when compared to their pulsatile-flow predecessors. Typically, continuous-flow VADs are designed with axial- or centrifugal- (radial) configurations. The pressures and flow rates vary dramatically in the native heart as blood is moved  from the LV to the aorta.  This dissertation presents pressure-flow characteristics for both axial- and centrifugal-flow VADs within a wide range of pressure differential values under uniform conditions, by means of a novel, open-loop flow system. Current techniques employ a closed-loop system to determine pump performance. A closed-loop system  does not allow pressure differentials less than or equal to zero to be achieved. The native heart experiences pressure gradients near zero across the aortic valve during systole, which is essentially where the VAD is placed. Thus, an open-loop flow system with independently adjustable preload and afterload pressures is required to reach physiologically-relevant pressure differential regions that approximate the  pressure gradient across the aortic valve during systole.  Additional modifications made to the open-loop flow system generate pulsatile flow type conditions, which mimic those of the native LV. With this type of in vitro  test system, not only can general hydrodynamic performance and hydraulic efficiency of VADs be measured, but also off-design operational performance under dynamic flow conditions can be characterized. This research explores hydrodynamic performance characteristics of axial- and centrifugal-flow VADs to determine design advantages that each have. Device characteristics include pressure-flow performance  curves, pressure sensitivity, pulsatility index, and pulsatility ratio. Performance curves and other relevant attributes are investigated at previously unreported pressure-flow regions. Performance is evaluated theoretically, computationally, and experimentally  under both steady-state, continuous-flow and pulsatile-flow circumstances.
Infeção Tardia por Streptococcus do Grupo B: Uma Manifestação em Espelho em Gémeos Heterozigóticos
Creators: name: Almeida, Sofia Rodrigues
name: Santo, Rita Espírito
name: Chaves, Margarida
name: Martins, Mafalda
name: Cunha, Manuel Sousa
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A infeção tardia por Streptococcus do grupo B ocorre entre os 7-90 dias de vida e pode afetar crianças sem antecedentes relevantes. A adenite é uma forma de apresentação rara, podendo ser o único sinal de bacteriemia. Descreve-se o caso de dois lactentes gémeos heterozigóticos, com pesquisa de Streptococcus do grupo B negativa na gestação e parto por cesariana eletiva. Aos 55 dias de vida o primeiro gémeo foi internado por febre, irritabilidade e recusa alimentar, detetando-se uma tumefação cervical direita, dolorosa à palpação. Dois dias depois, o segundo gémeo iniciou quadro de febre e irritabilidade marcada, com tumefação cervical à esquerda, motivando também internamento. Em ambos os casos ocorreu isolamento de Streptococcus do grupo B na hemocultura, sensível à penicilina. Cumpriram antibioterapia intravenosa durante 10 dias, com boa evolução clínica e resolução completa do quadro. O grau de suspeição e a terapêutica instituída precocemente foram fundamentais para o bom prognóstico destes casos.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23472.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Contact force analysis under femoral head micro-separation for ceramic-on-ceramic hip implants: finite element analysis and experimental validation
Creators: name: Kakarla, Lakshmi Navya Deepika
Publisher: name: University of Utah
Year: 2012
Subjects: Contact force
Femoral head
Micro-separation
Microseparation
Ceramic
Hip implants
Contact stresses

description: When a prosthetic hip fails to perform like an ideal ball-and-socket joint but instead permits small subluxation and edge loading between the joint members, the bearing surfaces are subjected to increased contact stresses and wear that could ultimately cause failure and require costly and painful revision of the prosthesis. The objectives of the present study were (1) to model and analyze one such adverse motion: rapid femoral head reduction; (2) to quantify the ensuing dynamic contact force and elevated contact stresses; and (3) to improve the relevance of hip joint wear tests by providing validated contact force values representing worst case conditions in ceramic-on-ceramic hip bearings. A dynamic model of head micro-separation occurring during normal human gait was examined via a combined approach of laboratory testing and finite element analysis (FEA). The testing validated the FEA (though with some explainable error) against measured values for normal velocity at a point on the femoral head and strain on the femur and femoral neck. Then, the FE model was used to analyze the contact forces and the stresses during the edge loading. This approach contradicted a key hypothesis of the study, specifically, that the duration of edge loading contact would be close to the period of vibrations in the femur. It was revealed that the peak contact stresses are strongly influenced by the model's input conditions rather than the femur's natural vibration characteristics. The results showed an increase in the peak femoral head velocity and the peak femoral strains during the reduction event as the micro-separation increased. Validation of the FEA against experimental results showed large errors in velocity and relatively small errors in strain. The submodel analysis showed much higher contact force and contact stress than the global model analysis, which was attributed to boundary conditions (BCs) and limitations of the software used. A better understanding of the cause of the errors in the approach undertaken demands an improvement in the submodeling procedure, which involves a more detailed analysis beyond the scope of this study.
Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity
Creators: name: Sharabi, Shirley
name: Bresler, Yael
name: Ravid, Orly
name: Shemesh, Chen
name: Atrakchi, Dana
name: Schnaider-Beeri, Michal
name: Gosselet, Fabien
name: Dehouck, Lucie
name: Last, David
name: Guez, David
name: Daniels, Dianne
name: Mardor, Yael
name: Cooper, Itzik
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The blood–brain barrier (BBB) is limiting transcellular and paracellular movement of molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective function is the major hurdle for treating brain diseases such as brain tumors, Parkinson’s disease, Alzheimer’s disease, etc. It was previously demonstrated that high pulsed electrical fields (PEFs) can disrupt the BBB by inducing electroporation (EP) which increases the permeability of the transcellular route. Our goal was to study the effects of low PEFs, well below the threshold of EP on the integrity and function of the BBB. Ten low voltage pulses (5–100 V) were applied to a human in vitro BBB model. Changes in permeability to small molecules (NaF) were studied as well as changes in impedance spectrum and trans-endothelial electric resistivity. Viability and EP were evaluated by Presto-Blue and endogenous Lactate dehydrogenase release assays. The effect on tight junction and adherent junction protein was also studied. The results of low voltage experiments were compared to high voltage experiments (200–1400 V). A significant increase in permeability was found at voltages as low as 10 V despite EP only occurring from 100 V. The changes in permeability as a function of applied voltage were fitted to an inverse-exponential function, suggesting a plateau effect. Staining of VE-cadherin showed specific changes in protein expression. The results indicate that low PEFs can transiently disrupt the BBB by affecting the paracellular route, although the mechanism remains unclear.
O Que Sabem os Pais Sobre o Tratamento de Queimaduras
Creators: name: Barroso, Fábio
name: Lachado, Ana
name: Melo, Ana Reis E
name: Pinto, Fátima
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A nível mundial, oito em cada 100 000 crianças são hospitalizadas anualmente na sequência de uma queimadura. Pretendeu-se avaliar o grau de conhecimento dos pais portugueses sobre o tratamento básico de queimaduras. Métodos: Estudo observacional, transversal, no qual foram incluídos 644 pais que responderam a um questionário disponível em plataformas online de pediatria no período de 26 de julho a 12 de agosto de 2016. O questionário incluía informação demográfica, questões sobre tratamento geral de queimaduras e perguntas de verdadeiro / falso. Aplicação de água fria durante 15-20 minutos e cobertura com película aderente foram consideradas medidas iniciais ideais. Resultados: Dos 644 pais, a maioria era do sexo feminino (92,9%) e tinha 26-35 anos (50,9%), sendo que 72,0% tinham frequentado o ensino superior. Foi relatada história de queimadura em 16,3% dos casos, 89,5% das quais ocorreram em casa. Em termos de abordagem, 51,2 % tratariam a queimadura com água fria. No entanto, 95,7% têm um conhecimento inapropriado quanto à duração e apenas 1,6% cobriria a zona com película aderente. Cerca de 3,7% optariam pelas formulações caseiras, incluindo gelo, mel, pasta dos dentes e gorduras. Sexo feminino e história prévia de queimadura foram associados a maior conhecimento sobre o tratamento das queimaduras. Discussão: O conhecimento dos pais relativamente ao tratamento inicial das queimaduras é limitado. A criação de um programa educacional nacional e a promoção de estratégias adequadas de tratamento das queimaduras poderão ser úteis.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Burnt Area Detection In Pdn Using Two Post Fire Images
Creators: name: Amici, Stefania
name: Santurri, Leonardo
name: Piscini, Alessandro
Publisher: name: Zenodo
Year: 2018
Subjects: Sentinel 2A
willdfire
NDVI
Dovestones
dNBR
dNDVIp

description: The dynamic of open fire phenomena makes remote sensing from satellite a good tool for both fire detection and burn area assessment. A multi-temporal approach rely on pre and post fire multispectral  images to derive vegetation maps (e.g.  Normalised Differential Vegetation Index-NDVI, dNBR )

However, in countries such as UK a pre-and post fire pair of  cloud free images  from  VNIR  operating satellite may be not available. This work focuses on detecting a burned area when only two post fire images  are available.

The study area is Dovestones- Stalybridge  that was affected by a fire on 10th  April 2016.  Data acquired by Landsat OLI  (30mx30m  pixels) on 4 May and 5 June 2016 and Sentinel 2A on 20 April 2016 and 19 July 2016 were used  to derive dNDVI -differential NDVI- by using two post images. A validation fieldtrip was conducted  on July 2016 to identify  re-growing and burn patches  to  validate the obtained results. The results are promising and the techniques can be used to  validate burn area detection retrieved by using new SAR based methods or to complement more traditional methods based on dNDVI or dNBR by using a pre- post pairs. Work is in progress as more test cases  are needed to derive a threshold approach.
Sonnenfleckenzeichnung Nr. 23437.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Duplicação Tubular Colorretal
Creators: name: Morão, Sofia
name: Ladeira, Catarina
name: Knoblich, Maria
name: Mendes, Pedro Paulo
name: Alves, Rui
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Date of submission: 01-01-2020 | Date of acceptance: 01-06-2020 | Published: 22-01-2020
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23509.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.11.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23454.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Roncopatia em Idade Pediátrica: Sem Fim à Vista? Fatores de Risco para Persistência de Sintomas Pós-Tratamento Cirúrgico
Creators: name: Oliveira, Joana A.
name: Martins, Rosa
name: Ferreira, Rosário
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A perturbação respiratória do sono é frequente em crianças e associa-se a diversas complicações. A hipertrofia adenoamigdalina é o principal fator de risco, sendo a adenoamigdalectomia o tratamento de primeira linha. Vários autores têm mostrado moderada taxa de persistência de sintomas pós-cirurgia. O objetivo desde estudo foi analisar a persistência de sintomas pós-cirurgia e identificar possíveis fatores de risco. Métodos: Estudo retrospetivo, longitudinal, que incluiu crianças seguidas na consulta de patologia do sono e submetidas a adenoamigdalectomia por perturbação respiratória do sono. Consulta de registos clínicos e aplicação de questionário telefónico aos pais sobre a presença de sintomas pós-cirurgia. Análise descritiva e bivariada, testes não paramétricos (p < 0,05). Resultados: Foram incluídas 89 crianças, 59,2% do sexo masculino, mediana da idade à data da cirurgia 4,8 anos (mínimo 15 meses, máximo 17 anos). Persistência de sintomas em 31,5%, mais frequente em crianças operadas < 3,5 anos (45,8% vs 23,4%, p = 0,04), com rinite alérgica (55,6% vs 23,9%, p = 0,009) e com asma (57,1% vs 25,3%, p = 0,017). Tempo decorrido desde a cirurgia mais longo no grupo com persistência de sintomas (3,9 vs 1,5 anos, p = 0,001). A distribuição por sexo e a prevalência de obesidade, prematuridade e anomalias craniofaciais não diferiram significativamente entre os dois grupos. Discussão: Um número significativo de doentes reportou persistência de sintomas após adenoamigdalectomia. Cirurgia em idade precoce, maior tempo decorrido desde a cirurgia, rinite e asma parecem associar-se a maior taxa de persistência. Estes resultados sugerem a necessidade de avaliação sistemática de comorbilidades e follow-up pós-cirurgia a longo-prazo.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Places: parallelism for racket
Creators: name: Tew, Kevin B.
Publisher: name: University of Utah
Year: 2013
Subjects: Message passing
Parallelism
Programming languages
Racket

description: Places and distributed places bring new support for message-passing parallelism to Racket. This dissertation describes the programming model and how Racket's sequential runtime-system was modified to support places and distributed places. The freedom to design the places programming model helped make the implementation tractable; specifically, the conventional pain of adding just the right amount of locking to a big, legacy runtime system was avoided. The dissertation presents an evaluation of the places design that includes both real-world applications and standard parallel benchmarks. Distributed places are introduced as a language extension of the places design and architecture. The distributed places extension augments places with the features of remote process launch, remote place invocation, and distributed message passing. Distributed places provide a foundation for constructing higher-level distributed frameworks. Example implementations of RPC, MPI, map reduce, and nested data parallelism demonstrate the extensibility of the distributed places API.
Structural studies of proteasome assembly chaperones and activator complexes
Creators: name: Stadtmueller, Beth Marie
Publisher: name: University of Utah
Year: 2012
Subjects: Proteasome
Structural biology
Assembly chaperones
Activator complexes

description: This dissertation describes structural and biochemical studies on proteasome assembly chaperones and proteasome activator complexes. Chapters 1 and 2 provide a detailed introduction to proteasome structure and function and related, original research is described in Chapters 3-5.  Proteasomes are large multi-subunit proteases that are required to regulate diverse cellular processes. The 20S proteasome is comprised of four heptameric rings, two ? type surrounding two ? type, with proteolytic sites sequestered at its center. Eukaryotic cells assemble the 20S proteasome using a highly orchestrated process during which they employ intermolecular assembly chaperones. Included among 20S assembly chaperones is the Pba3-Pba4 complex. Chapter 3 reports the crystal structure of the Pba3-Pba4 complex from  Saccharomyces cerevisiae and associated biochemical studies. Collectively this research supports a model in which a yeast Pba3-Pba4 heterodimer interacts directly with the ?5 subunit to facilitate the incorporation of neighboring ? subunits during early stages of 20S assembly.   Three structurally and functionally distinct proteasome activators can bind to 20S ? rings and open an entrance/exit pore, consequently regulating substrate access to the proteolytic sites. The PA26 activator uses its C-terminal tails to bind conserved ? subunit residues and uses an internal activation loop to contact and reposition the proteasome Pro17 reverse turn resulting in gate opening. The unrelated PAN/19S activators can activate the proteasome using only their C-terminal tail residues, which contain a conserved penultimate Tyr motif and have been reported to cause gate opening  by inducing a rocking motion of ? subunits rather than by directly contacting the Pro17 turn. Chapter 4 of this dissertation reports crystal structures and binding studies of proteasome complexes with PA26 constructs that display modified C-terminal residues, including those corresponding to PAN. These data suggest that PA26 and PAN/19S Cterminal residues bind superimposably but in the case of PAN/19S use their penultimate Tyr side chain to contact the proteasome Gly19 carbonyl oxygen and stabilize the Pro17 turn in the open conformation. This finding, and data from the recently reported Blm10  20S complex crystal structure, support a unified model for proteasome gate opening in which three structurally and functionally distinct activator complexes induce gate  opening by directly contacting and repositioning the proteasome's Pro17 turn.   A recently published report challenges this model and is discussed and evaluated in Chapter 5. We favor the model in which all three proteasome activators trigger gate opening by directly interacting with and repositioning the 20S Pro17 reverse turn, although additional analysis and experiments will be needed to resolve differences between existing models.
Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity
Creators: name: Sharabi, Shirley
name: Bresler, Yael
name: Ravid, Orly
name: Shemesh, Chen
name: Atrakchi, Dana
name: Schnaider-Beeri, Michal
name: Gosselet, Fabien
name: Dehouck, Lucie
name: Last, David
name: Guez, David
name: Daniels, Dianne
name: Mardor, Yael
name: Cooper, Itzik
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The blood–brain barrier (BBB) is limiting transcellular and paracellular movement of molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective function is the major hurdle for treating brain diseases such as brain tumors, Parkinson’s disease, Alzheimer’s disease, etc. It was previously demonstrated that high pulsed electrical fields (PEFs) can disrupt the BBB by inducing electroporation (EP) which increases the permeability of the transcellular route. Our goal was to study the effects of low PEFs, well below the threshold of EP on the integrity and function of the BBB. Ten low voltage pulses (5–100 V) were applied to a human in vitro BBB model. Changes in permeability to small molecules (NaF) were studied as well as changes in impedance spectrum and trans-endothelial electric resistivity. Viability and EP were evaluated by Presto-Blue and endogenous Lactate dehydrogenase release assays. The effect on tight junction and adherent junction protein was also studied. The results of low voltage experiments were compared to high voltage experiments (200–1400 V). A significant increase in permeability was found at voltages as low as 10 V despite EP only occurring from 100 V. The changes in permeability as a function of applied voltage were fitted to an inverse-exponential function, suggesting a plateau effect. Staining of VE-cadherin showed specific changes in protein expression. The results indicate that low PEFs can transiently disrupt the BBB by affecting the paracellular route, although the mechanism remains unclear.