cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Profile Als Labore Des Privaten
Creators: name: Pittroff, Fabian
Publisher: name: Zenodo
Year: 2017
Subjects: Personhood
Privacy
Self-care
Accessibility
Composition
Social Laboratories

description: Im Zuge der Digitalisierung ist es zu einer neuen Verunsicherung des Privaten gekommen. Neben einer Krise der Kontrolle von Daten entfaltet sich eine Situation, in der die Erstellung und Streuung persönlicher Daten attraktiv und notwendig ist. Die grundlegende These dieses Beitrags lautet, dass diese Situation mit der Art und Weise zu tun hat, wie Menschen in ihre Umwelten eingebunden werden und sich selbst einbinden. Zur Analyse werde ich deshalb drei Theorien zusammenbringen, die helfen zu klären, wie sich Menschen als Personen situieren. Digital vernetzte Profile spielen dabei eine entscheidende  olle, insofern sie die Möglichkeit eröffnen, persönliche Daten zu versammeln und sich mit deren Hilfe als Personen zu formieren. Vor diesem Hintergrund wird deutlich, dass der gegenwärtige Wandel des Privaten mit einer Transformation des Verhältnisses von Menschen zu ihrer Umwelt einhergeht. Profile erscheinen in dieser Situation als Instanzen einer Neuordnung von Privatheit und Personalität. Deshalb sollten Profile auch als Labore für neue Formen des Privaten gelesen werden.
description: Also available via the publisher: https://doi.org/10.14619/021
Ritual Sovereignty in Siam: Royal Sacraments and Brahmanical Liturgies in Ayutthaya and Rattanakosin
Creators: name: Saran Suebsantiwongse
Publisher: name: Silpakorn University Research Innovation and Creativity Administration Office
Year: 2020
Subjects: Vedic
kingship
Hinduism
Brahmanism
ritual

description: Humanities, Arts and Social Sciences Studies, 20, 2, 604-624
Physical Activity, Positive and Negative Symptoms of Psychosis, and General Psychopathology among People with Psychotic Disorders: A Meta-Analysis
Creators: name: Swora, Ernest
name: Boberska, Monika
name: Kulis, Ewa
name: Knoll, Nina
name: Keller, Jan
name: Luszczynska, Aleksandra
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: physical activity
subject: intervention
subject: psychotic disorder
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Objective: Existing reviews provided evidence for the associations between higher physical activity (PA) and lower negative symptoms of psychosis among people with schizophrenia. This meta-analysis goes beyond existing syntheses and investigates associations between PA, positive and negative symptoms of psychosis, as well as symptoms of general psychopathology (referring mostly to cognitive functioning) among people with schizophrenia, but also other psychotic disorders. The moderating roles of the type of diagnosis and the type of exercise intervention were explored. Methods: The study was registered with PROSPERO (CRD42018118236). Six electronic databases were searched; n = 27 experimental and observational studies were included, and psychotic symptoms-related data were recorded in one direction (higher values indicate better mental health and lower symptomatology). Results: Higher levels of PA (or participating in PA interventions) were associated with better mental health, that is, lower levels of positive symptoms (all studies: r = 0.170; experimental studies: SMD = 0.677), negative symptoms (all studies: r = 0.214; experimental studies: SMD = 0.838), and general psychopathology (all studies: r = 0.451; experimental studies: SMD = 1.511). The type of diagnosis (schizophrenia vs. other psychotic disorders) did not moderate these associations. Conclusions: We found a consistent pattern of associations between higher levels of PA and lower positive, negative, and general psychopathology symptoms in people with schizophrenia and those with other psychotic disorders.
Análisis del Movimiento Oscilatorio
Creators: name: Bueno-Pascual, Felix Eduardo
Publisher: name: figshare
Year: 2022
Subjects: subject: 20501 Classical and Physical Optics
subject: FOS: Physical sciences

description: Aprovechamos las capacidades de Maple en la modelación del movimiento tanto armónico simple como amortiguado; incluimos el caso del péndulo lineal y del no lineal. El paquete nos ofrece la posiblidad de presentar los resultados obtenidos en forma numérica, simbólica y gráfica. Comparamos nuestras soluciones con las obtenidas por aproximación numérica usando otra herramienta.
4,5-Bis(arylethynyl)-1,2,3-triazoles - A New Class of Fluorescent Labels: Synthesis and Applications
Creators: name: Govdi, Anastasia I.
name: Tokareva, Polina V.
name: Rumyantsev, Andrey M.
name: Panov, Maxim S.
name: Stellmacher, Johannes
name: Alexiev, Ulrike
name: Danilkina, Natalia A.
name: Balova, Irina A.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: 1,2,3-triazoles
subject: 1,3-diynes
subject: azide–alkyne cycloaddition
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Cu-catalyzed 1,3-dipolar cycloaddition of ethyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Sonogashira cross-coupling were used to synthesize a large series of new triazole-based push–pull chromophores: 4,5-bis(arylethynyl)-1H-1,2,3-triazoles. The study of their optical properties revealed that all molecules have fluorescence properties, the Stokes shift values of which exceed 150 nm. The fluorescent properties of triazoles are easily adjustable depending on the nature of the substituents attached to aryl rings of the arylethynyl moieties at the C4 and C5 atoms of the triazole core. The possibility of 4,5-bis(arylethynyl)-1,2,3-triazoles’ application for labeling was demonstrated using proteins and the HEK293 cell line. The results of an MTT test on two distinct cell lines, HEK293 and HeLa, revealed the low cytotoxicity of 4,5-bis(arylethynyl)triazoles, which makes them promising fluorescent tags for labeling and tracking biomolecules.
Μeat Quality Traits as Affected by the Dietary Inclusion of Food Waste in Finishing Pigs
Creators: name: Giamouri, Elisavet
name: Papadomichelakis, George
name: Pappas, Athanasios C.
name: Simitzis, Panagiotis E.
name: Galliou, Fenia
name: Paßlack, Nadine
name: Zentek, Juergen
name: Lasaridi, Katia
name: Fegeros, Kostas
name: Manios, Thrassyvoulos
name: Tsiplakou, Eleni
name: Zervas, George
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: food waste
subject: pigs
subject: growth performance
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft

description: An increasing world population along with increasing human needs have raised demand for animal origin products. Moreover, high prices of conventional animal feeds have led to a demand for alternative feedstuff. Food waste can be an alternative feed ingredient. The aim of the present study was to investigate the effect of dietary inclusion of dried hotel residues (DHR) on the growth performance, blood biochemical parameters and meat quality traits in finishing pigs. In each of the 2 trials conducted, 20 castrated male pigs were allotted into 2 treatments. In both trials, control treatment pigs were fed a corn-soybean meal-based diet without hotel residues. In the first trial, a DHR1 treatment contained 100 g DHR1/kg with meat residues (approximately 5%). In the second trial, a DHR2 treatment, contained 80 g DHR2/kg with no meat residues. Average daily feed intake tended to be lower and average daily weight gain was lower in DHR1 compared to control pigs in the first trial, while in the second no differences were detected. However, final body weight, FCR and dressing percentage were not affected in any of the two trials. Minor differences in several meat physical traits, hematological parameters were observed among treatments and trials. In conclusion, the results indicate that the dietary addition of DHR did not affect the feed utilization and the quality of the produced meat; hence, the use of DHR in pig feeding can be supported.
Photovoltaics and the solar rebound: Evidence for Germany
Creators: name: Frondel, Manuel
name: Kaestner, Kathrin
name: Sommer, Stephan
name: Vance, Colin
Publisher: name: Technische Universität Dortmund
Year: 2020
Subjects: subject: Feed-in tariffs
subject: German Residential Energy Consumption Survey (GRECS)
subject: GMM system estimator
subject: 310
subject: 330
subject: 620
subject: Fotovoltaikanlage
subject: Energieverbrauch
subject: Verbraucherverhalten
subject: Haushalt

description: Recent research suggests that households would increase their electricity consumption in the aftermath of installing photovoltaics (PV) panels, a behavioral change commonly referred to as the solar rebound. Drawing on panel data originating from the German Residential Energy Consumption Survey (GRECS), we employ panel estimation methods and the dynamic system estimator developed by Blundell and Bond (1998) to investigate the solar rebound effect, thereby accounting for simultaneity and endogeneity issues relating to PV installation and the electricity price. Our empirical results suggest that PV panel adoption of households hardly reduces the amount of electricity taken from the grid. As we derive theoretically, this outcome implies that the rebound reaches a maximum that is bounded by about 30% for German households. Yet, we are skeptical of whether there is such a large solar rebound effect given the strong economic incentives to feed solar electricty into the public grid in the past.
description: Discussion Paper / SFB823;27/2020
In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist
Creators: name: Puls, Kristina
name: Olivé-Marti, Aina-Leonor
name: Pach, Szymon
name: Pinter, Birgit
name: Erli, Filippo
name: Wolber, Gerhard
name: Spetea, Mariana
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: GPCRs
subject: kappa-opioid receptor
subject: antagonists
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist but its binding/selectivity and activation profile at the KOR and delta-opioid receptor (DOR) remain elusive. In this study, we present an in vitro, in vivo and in silico characterization of Compound A by revealing this ligand as a KOR antagonist in vitro and in vivo. In the radioligand competitive binding assay, Compound A bound at the human KOR, albeit with moderate affinity, but with increased affinity than to the human MOR and without specific binding at the human DOR, thus displaying a preferential KOR selectivity profile. Following subcutaneous administration in mice, Compound A effectively reverse the antinociceptive effects of the prototypical KOR agonist, U50,488. In silico investigations were carried out to assess the structural determinants responsible for opioid receptor subtype selectivity of Compound A. Molecular docking, molecular dynamics simulations and dynamic pharmacophore (dynophore) generation revealed differences in the stabilization of the chlorophenyl moiety of Compound A within the opioid receptor binding pockets, rationalizing the experimentally determined binding affinity values. This new chemotype bears the potential for favorable ADMET properties and holds promise for chemical optimization toward the development of potential therapeutics.
Potentially Bio-Accessible Metabolites from an Extract of Cornus mas Fruit after Gastrointestinal Digestion In Vitro and Gut Microbiota Ex Vivo Treatment
Creators: name: Olędzka, Agata
name: Cichocka, Katarzyna
name: Woliński, Konrad
name: Melzig, Matthias F.
name: Czerwińska, Monika E.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: cornelian cherries
subject: cornuside
subject: iridoids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Targeting pancreatic lipase and α-amylase by digestion-derived fractions of ethanolic-aqueous (60%, v/v) extract from Cornus mas fruit (CM) in relation to the control and prevention of metabolic disorders, including diabetes, was the first purpose of the present study. Taking into consideration the significance of bio-accessibility of compounds, we attempted to identify metabolites of CM after gastrointestinal digestion in vitro, as well as their kinetic changes upon gut microbiota treatment. The digestion of extract was simulated with digestive enzymes in vitro and human gut microbiota ex vivo (1 h, 3 h, 6 h, 24 h), followed by chromatographic analysis using the UHPLC-DAD-MSn method. The effect of fractions from gastrointestinal digestion in vitro on the activity of pancreatic lipase and α-amylase was studied with fluorescence-based assays. The gastric and intestinal fractions obtained after in vitro digestion of CM inhibited pancreatic lipase and α-amylase. Loganic acid as the main constituent of the extract was digested in the experimental conditions in contrast to cornuside. It was found in most analytes such as salivary, gastric, intestinal, and even colon (fecal slurry, FS) fractions. In all fractions, kaempferol hexoside and reduced forms of kaempferol, such as aromadendrin, and benzoic acid were assigned. The signals of tannins were detected in all fractions. Cornusiin A was tentatively assigned in the gastric fraction. The metabolites originating from kinetic analytes have been classified mainly as phenolic acids, hydrolyzable tannins, and flavonoids. Phenolic acids (protocatechuic acid, gallic acid), tannins (digalloylglucose, tri-O-galloyl-β-D-glucose), and flavonoids (aromadendrin, dihydroquercetin) were detected in the late phases of digestion in fecal slurry suspension. Cornuside was found in FS analyte after 3 h incubation. It was not detected in the samples after 6 and 24 h incubation with FS. In conclusion, cornuside, aromadendrin, and phenolic acids may be potentially bio-accessible compounds of CM. The presence of plants’ secondary metabolites in the intestinal fractions allows us to indicate them as responsible for decreasing glucose and lipid absorption.
Tuning Of Physical And Electrochemical Properties Of Nanocrystalline Tungsten Oxide Through Ultraviolet Photo Activation
Creators: name: P.T.G. Gayathri
name: S.Sajitha
name: I.Vijitha
name: S.S.Shaiju
name: Biswapriya Deb
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Supplementary material from Marriage does not relate to major histocompatibility complex: a genetic analysis based on 3691 couples
Creators: name: Croy, Ilona
name: Ritschel, Gerhard
name: Kreßner-Kiel, Denise
name: Schäfer, Laura
name: Hummel, Thomas
name: Havlíček, Jan
name: Sauter, Jürgen
name: Ehninger, Gerhard
name: Schmidt, Alexander H.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine

description: Optimization of chances for healthy offspring is thought to be one of the factors driving mate choice and compatibility of the major histocompatibility complex (MHC) is assumed to determine the offspring's fitness. While humans have been claimed to be able to perceive information of MHC compatibility via the olfactory channel, it remains unknown whether humans use such information for mate choice. By investigation of 3691 married couples, we observed that the high polymorphism of MHC leads to a low chance for homozygous offspring. MHC similarity between couples did not differ from chance, we hence observed no MHC effect in married couples. Hormonal contraception at the time of relationship initiation had no significant effect towards enhanced similarity. A low variety of alleles within a postcode area led to a higher likelihood of homozygous offspring. Based on this data, we conclude that there is no pattern of MHC dis-assortative mating in a genetically diverse Western society. We discuss the question of olfactory mate preference, in-group mating bias and the high polymorphism as potential explanations.
Investigating the role of kisspeptin in human behaviour and physiology
Creators: name: Yang, Lisa Yan
Publisher: name: Imperial College London
Year: 2020

description: The neuropeptide kisspeptin is established as a master regulator of the reproductive axis within the hypothalamus. Kisspeptin and its receptor are also extensively distributed in extrahypothalamic brain regions and an expanding pool of animal data demonstrates that kisspeptin sits within an extensive functional and neuroanatomical framework through which it can integrate a range of internal and external cues with appropriate behavioural and neuroendocrine responses. In keeping with this, recent studies have revealed wide-reaching effects of kisspeptin on key behaviours such as olfactory-mediated partner preference, sexual responses, mood and emotions. To date, only one human study has investigated the effects of kisspeptin on extra-hypothalamic brain pathways, with findings that peripheral kisspeptin administration enhances limbic brain processing in healthy men in response to sexually arousing and couple-bonding images. In this thesis, I have used a combination of hormonal, psychometric and functional neuroimaging techniques to study the effects of kisspeptin on two currently unexplored aspects of human behaviour and their underlying brain processes; 1) olfactory and visually stimulated sexual attraction; 2) appetite and food intake. My results show that kisspeptin enhances brain processing in response to olfactory and visual cues of attraction but has no effect on brain responses to food images, with no associated changes in appetite or food intake. Collectively, the findings of this thesis generate novel human data which support and extend the animal literature regarding the role of kisspeptin in sexual attraction and related behaviours, while answering key functional and mechanistic questions concerning the role of kisspeptin in human appetite and food intake.
Utilisation d'outils d'évaluation de la durabilité des exploitations agricoles pour évaluer les im-pacts de la diversification
Creators: name: Curran, Michael
Publisher: name: Zenodo
Year: 2022
Subjects: DiverIMPACTSPA
Performance des exploitations en matière de durabilité

description: Problème : Le secteur agricole est confronté à des défis mondiaux en matière de durabilité, notamment la surutilisation de produits agrochimiques, l’augmentation des émissions de gaz à effet de serre, la dégradation des sols, la « simplification » des paysages, les mauvaises conditions de travail, la baisse de la rentabilité et la perte des moyens de subsistance (IAASTD 2009, Poore et Nemecek 2018). Solution : Pour relever ces défis, plusieurs « outils d’évaluation de la durabilité » (SAT) liés à l’exploitation ont été développés pour permettre aux agricultrices et agriculteurs d’évaluer leurs performances et de prendre de meilleures décisions en matière de gestion
A Study Of The Thickness And Ageing Dependent Variation In The Electrochromic Property Of V2O5 Xerogel Thin Films
Creators: name: Sajitha Surendren
name: Biswapriya Deb
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Bulk Superconductivity At Tc = 0.79 K In Eu2Srbi2S4F4: An Ac-Susceptibility Investigation
Creators: name: N. Manivannan
name: G. Kalai Selvan
name: Z. Haque
name: L. C. Gupta
name: A. K. Ganguli
name: S. Arumugam
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Biased signalling of Dual GLP-1R/GCGR agonists
Creators: name: Pickford, Philip John
Publisher: name: Imperial College London
Year: 2020

description: Dual agonists acting at both the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) are a novel recent class of drugs which have been shown to simultaneously correct hyperglycaemia and cause sustained weight loss, making them a major drug class to treat the obese diabetic patient population. It is known that selectively activating certain intracellular pathways associated with a particular G protein-coupled receptor (GPCR), termed biased agonism, can simultaneously increase therapeutic efficacy and reduce associated side effects which can limit dosage of GPCR-targeting drugs. This approach has not been investigated in dual GLP-1R/GCGR agonists, yet it could improve the therapeutic efficacy of this drug class. A GLP-1R/GCGR agonist peptide, “SRB103Gln3”, was discovered that displays significant reductions in β-arrestin recruitment at both receptors versus a comparator, “SRB103His3”, with both peptides maintaining full cAMP signalling. In hepatoma cells, SRB103Gln3 displayed more prolonged signalling than SRB103His3 after overnight stimulation, suggesting SRB103Gln3 could prolong signalling at the GCGR by reducing β-arrestin-mediated receptor desensitisation. In lean and obese mice, SRB103Gln3 displayed greater anti-hyperglycaemic effects at prolonged timepoints compared to SRB103His3 with little reduction in acute food intake. Studies using Gcgr-/- mice were performed in an attempt to identify the contribution of GCGR to the observed effects. When administered chronically, SRB103Gln3 maintains its optimal anti-hyperglycaemic effects compared to SRB103His3, and both dual agonists displayed a trajectory suggesting greater weight loss compared to the GLP-1R mono-agonist liraglutide. In rats, SRB103Gln3 had profound effects on reducing food intake and weight loss compared to SRB103His3. These findings highlight the benefit of selectively reducing β-arrestin recruitment associated with dual GLP-1R/GCGR agonist signalling, and could improve the therapeutic utility of this class of compounds.
DA INTROJEÇÃO AO DESMENTIDO: AS CONTRIBUIÇÕES DE SANDOR FERENCZI PARA A PRÁXIS PSICANALÍTICA.
Creators: name: Brito dos Santos, Marcella
Publisher: name: figshare
Year: 2022
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Applied Psychology

description: TCC pós-graduação em teoria psicanalítica pela Faculdade Venda Nova do Imigrante no ano de 2022. Nota 10.
Towards happiness and psychological well-being: understanding and designing positive experiences with conversational agents
Creators: name: Yang, Xi
Publisher: name: Imperial College London
Year: 2020

description: Happiness is our ultimate goal and often a consequence of day-to-day experiences. These experiences are inevitably affected by the products we interact with, ranging from everyday artefacts, to interactive technologies, and increasingly, intelligent tools such as conversational agents (CAs). Design and technology greatly shape how we feel, think, and behave in those experiences, and thus influence happiness and well-being. However, when designing for happiness, what experiences to strive for, and how to achieve them are still unclear. In particular, the lack of knowledge and design support for newly emerging products such as CAs is more evident than others. Hence, this thesis aims to gain better understanding of the experiences that support well-being and provide guidance to help design such experiences. This aim is achieved through a comprehensive literature review followed by four explorative studies. First, the scientific and design literature on happiness and well-being were reviewed, together with relevant works on CAs. This review develops the knowledge foundation for the thesis. Next, an empirical study investigated which and how everyday products contribute to well-being. The study identified seven well-being supportive experience themes and routes to creating them through products. Motivated by the recent AI development, the focus was then shifted from everyday artefacts to CAs. The next study explored users’ affective experiences with CAs. The findings present four main usage scenarios, the factors influencing affective responses, and implications for designing positive ones. To provide a eudaimonic perspective on CA experiences, an interview study was conducted to explore Self-Determination Theory (SDT) in the CA context. The findings show how the needs of competence, autonomy, and relatedness could be fulfilled or undermined with CAs. Based on the findings, ten design guidelines were developed, and later evaluated through a survey study. Together, these studies offer practical design support for CAs grounded in SDT.
The impact of mental disorders on hospital utilisation and in-hospital mortality among elderly patients with diabetes in England
Creators: name: Chen, Chih-Yu (Alex)
Publisher: name: Imperial College London
Year: 2020

description: Background and Introduction: The rapidly increasing incidence and prevalence of diabetes and the progressively ageing population are unstoppable global trends. In a real-world setting, older people often suffer from multiple chronic physical or mental disorders, and it is, therefore, necessary to evaluate the impact of these disorders on hospital utilisation and mortality among older adults with diabetes. Methods: A systematic review was conducted to understand the associations between mental/physical disabilities and medical utilisation/cost among elderly patients with diabetes. Three observational studies by using HES inpatient database were also conducted. From 2011-12 to 2013-14, patients who were 65 years old or above with diabetes were included. Multivariate regression models were performed to examine: (1) the impact of mental and physical disorders on hospital length of stay (2) the impact of physical or mental disorders on in-hospital mortality (3) the impact of mental and physical disorders on length of stay in hospital and in-hospital mortality of patients in different treatment units. Results: Male gender, increasing age, white ethnicity, patients who lived in more deprived areas, and patients with mental or physical disorders had a higher risk for longer hospital length of stay and in-hospital mortality. Elderly patients with mental disorders had 5.88 times greater incidence Rate Ratio (IRR) for hospitalisation, and 10.96 times risk for in-hospital mortality. Patients with mood disorders had 6.54 times greater IRR for hospitalisation, and patients with dementia had 13.9 times risk for in-hospital mortality. Patients with mental disorders in ophthalmology department had 15 times higher IRR for hospitalisation. Conclusions: Elderly diabetic patients with mental disorders have higher medical costs and in-hospital mortality than patients with diabetes only. Patients with dementia and mood disorders are the high-risk groups. To reduce medical costs and improve quality of care, early intervention and prevention for elderly diabetic patients with dementia and mood disorders are needed. Because the HES database does not include the relevant biochemical data during the patient’s hospitalisation, further studies to connect to the hospital-level database to investigate the key reasons why patients with mental disorders can have a high risk for longer hospital length of stay and in-hospital mortality would be the future research.
Impact of M protein loss and release of extracellular M protein on streptococcal disease
Creators: name: Huse, Kristin Krohn
Publisher: name: Imperial College London
Year: 2020

description: Background: The streptococcal cell surface M protein is arguably the most studied virulence factor of S. pyogenes and is postulated to be essential for S. pyogenes survival in the human host through mechanisms which culminate in evasion of opsonophagocytic killing. Despite the central role ascribed to M protein in combatting bacterial clearance, we identified selection and emergence of M protein defective S. pyogenes which was related to a premature stop codon and secretion during experimental infection. We therefore set out to determine the impact of M protein loss and the release of extracellular M protein on streptococcal disease. Methods: Isogenic strains with mutations in emm1 were constructed using standard techniques. Adhesion to host factors was measured using solid phase adherence assays, and bacterial survival and uptake were assessed in human whole blood and neutrophil phagocytosis assays. Bacterial survival and dissemination was investigated using in vivo models of intramuscular and intranasal infections, including coinfections to determine competitive advantage of strains. The prevalence of M protein mutations in whole genome sequences was analysed and the effect of vaccination using M1 on bacterial clearance was assessed. Results: M1 protein mutants were unable to bind fibrinogen, fibronectin and collagen, and were vulnerable to immune killing and neutrophil uptake in comparison to the WT parent strain in vitro. Surprisingly, and in contrast to in vitro clearance studies, M protein mutations did not affect bacterial survival 3 h after intramuscular infection of mice. The strain shedding truncated M protein was recovered in greater numbers than the parent strain expressing full length anchored M protein from certain niches 24 hours post infection, such as lymph nodes. This advantage was confirmed using coinfection experiments. In contrast, M protein mutants were unable to establish intranasal infection in mice. While no other truncating mutations were found in M protein when analysing whole genome sequences, it was shown that all M1 S. pyogenes tested secrete soluble M protein during normal culture. Conclusion: M protein is not required for survival of S. pyogenes during invasive infection, and some M protein mutations seem to provide an advantage in the lymphatic niche. Expression of soluble M protein is an important characteristic of all S. pyogenes strains and may affect immune evasion and pathogenesis.
title: Thelen Technopark and the Legal Effects of the Services Directive in Purely Internal and Horizontal Disputes
Creators: name: Lindeboom, Justin
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: direct effect
subject: directives
subject: Services Directive
subject: purely internal situation
subject: art. 49 TFEU
subject: art. 16 CFR

description: European Papers - A Journal on Law and Integration, 2022 7(1), 305-326
description: European Forum Insight of 11 June 2022
description: I. Introduction. - II. The judgment of the Court of Justice. - II.1. Factual and legal background. - II.2. Duty to ensure the full effect of directives, but no horizontal direct effect. - II.3. State liability as a remedy for harmed individuals. - II.4. Purely internal situations and the scope of art. 49 TFEU. - III. The legal effects of directives: normative impact and (in)direct effects. - III.1. The prohibition of horizontal direct effect and the "normative impact" of invoking a directive. - III.2. The central role of the doctrine of consistent interpretation. - III.3. Horizontal effects of directives and the Charter of Fundamental Rights. - III.4. Is state liability enough? - IV. The road not taken: the opinion of AG Szpunar. - IV.1. Horizontal direct effect of the Services Directive and art. 49 TFEU in purely internal situations. - IV.2. Horizontal direct effect of the freedom of contract within the scope of the Services Directive. - V. Conclusion.
description: In Thelen Technopark (ECLI:EU:C:2022:33), the Court of Justice held that art. 15 of the Services Directive cannot be invoked against a conflicting national law in a horizontal dispute, even though the Court had already definitively established the incompatibility of this national law with the Services Directive in an earlier judgment. In view of the purely internal nature of the dispute - making art. 49 TFEU itself inapplicable - the individual harmed by the violation of the Services Directive could only recover his losses through a separate action for damages against the Member State. This Insight analyses Thelen Technopark in light of the logic and extent of the prohibition of horizontal direct effect of directives, the central role and limits of the doctrine of consistent interpretation, and the direct effect of the Charter of Fundamental Rights. It argues that the Court rightly did not extend the Man-gold case law on directives giving concrete expression to a general principle or fundamental right to directives giving concrete expression to a fundamental freedom. This Insight also elaborates on the two proposals of AG Szpunar to allow for horizontal direct effect of the Services Directive either as a specification of art. 49 TFEU, or as a legislative harmonisation of the proportionality of an interference with art. 16 of the EU Charter of Fundamental Rights (CFR). While thought-provoking and worthy of critical analysis, the Court in my view rightly did not follow AG Szpunar's opinion, which likely would have resulted in a doctrinal minefield.
Undoped And Mg2+- Doped Tio2Nanoparticelsfor Dsscs Activity
Creators: name: M. Prabhu
name: K. Ramachandran
name: N. Soundararajan
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Verzeichniß des Lehrer-Personals und der sämmtlichen Studirenden an der Königl. Ludwig-Maximilians-Universität in München 1834-35; 1835
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1835

description: Textfreie Seiten wurden entfernt.
Electronic Supplementary Material of "Visual cues of predation risk outweigh acoustic cues: a field experiment in black-capped chickadees"
Creators: name: Arteaga-Torres, Josue David
name: Wijmenga, Jan J.
name: Mathot, Kimberley J.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60801 Animal Behaviour
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Appendixes of detailed methodology, supplementary figures and supplementary tables for the main publication.
Le sorgho d'ensilage, une alternative au maïs d'ensilage
Creators: name: Krauss, Maike
name: van Run, Laurens
Publisher: name: Zenodo
Year: 2022
Subjects: DiverIMPACTSPA
Rotation
champ
fourrage
tolé-rance à la sécheresse

description: Problème : La production de fourrage de maïs d’ensilage devient de plus en plus difficile en raison de la dégradation de la qualité des sols, de la pression croissante des maladies et des ravageurs, des limitations légales des taux de fertilisation en N et en P, des risques accrus de sécheresse et d’excès d’eau dus au changement climatique. Solution : Les racines plus profondes du sorgho d’ensilage permettent une meilleure tolérance à la sécheresse et une augmentation du niveau de carbone dans le sol. Le sorgho d’ensilage tolère un moindre apport en engrais et se veut moins sensible aux ravageurs et aux maladies que le maïs.
D2.2 Analysis NIS directive Cross domain threats
Creators: name: Maliatsos, Kostas
name: Labrinoudakis, Costas
name: Andreas  Menegatos,
name: Lyvas, Christos
name: Kalloniatis, Christos
name: Kanatas, Athanasios
name: Mancilla, Rosella Omana
name: De Vito, Pietro
name: Giannakoulias, Alkiviadis
Publisher: name: Zenodo
Year: 2022
Subjects: #CitySCAPE #H2020 #multimodaltransport #cybersecurity

description: The initial objectives of the work carried out during Task 2.2 “Cross-domain threat analysis” include a detailed investigation of the current threat landscape against the major Operators of Essential Services (OES) and the Digital Service Providers (DSP) as defined by the EU Network and Information Security (NIS) directive. More specifically, six domains operating critical infrastructure of extreme importance for the prosperity of EU citizens have been identified: • Energy, • Transportation, • Health, • Finance, • Banking, • Water Supply/Facilities. CitySCAPE targets the Transportation domain offering enhanced security functionalities for the modern, urban, multimodal public transportation ecosystem. Nevertheless, the integration of digital services for the administration, control, management and operation of the critical infrastructure has created a common field of risks and threats related to cybersecurity incidents and attacks. Moreover, all domains are interconnected and interdependent with each other and, if no security measures are applied, are vulnerable to cascading risks and threats. This deliverable includes threat analysis on the aforementioned NIS directive domains, including also DSPs that are offering cross-domain support over all essential services. This analysis, makes clear that a large set of common generic threats for the OESs/DSPs in different domains is identified. Additionally, the deliverable describes a methodology and criteria to be applied for the identification of OES and DSPs as well as the identification of serious incidents. Thus, in order to facilitate the estimation of the criticality of potential incidents, a detailed set of evaluation criteria is proposed. For each criterion, estimates on threshold values/metrics are also provided.
D2.3 Multimodal Transport System_ System Modelling, Risk Analysis and Management, GDPR Compliance
Creators: name: Lyvas, Christos
name: Kalloniatis, Christos
name: Maliatsos, Kostas
name: Lambrinoudakis, Costas
name: Kanatas, Athanasios
name: Menegatos, Andreas
name: Thrasyvoulos Giannakopoulos
Publisher: name: Zenodo
Year: 2022
Subjects: #CitySCAPE #H2020 #multimodaltransport #cybersecurity

description: This deliverable presents the results of the work carried out during Task 2.2 entitled “Cross-domain threat analysis”. The main objectives of the task were to: a) present a detailed investigation of the current threat landscape D2.3 Multimodal Transport System: System Modelling, Risk Analysis and Management, GDPR Compliance 7 against the major Operators of Essential Services (OES) and the Digital Service Providers (DSP), b) model the multi-modal transportation ecosystem under the CitySCAPE context and propose a risk analysis methodology for it, and c) study and investigate the different categories of personal data that will be processed by the multimodal under the requirements. While the results for the threat landscape, were provided in “D2.2 Analysis NIS directive Cross domain threats and proof of concepts”, in this deliverable: • A new risk analysis approach is presented with the proposal of a new conceptual model capable to robustly and hierarchically support risk modeling of the multimodal transport ecosystem. • In conjunction with the work delivered by D2.4 “Cascading Risks in the Multimodal Transportation Platforms”, the multimodal ecosystem architecture for the CitySCAPE use cases is defined with identification of assets and their interconnections. CitySCAPE follows an asset-based risk analysis approach – where all types of assets are considered (Hardware, Software, Connectivity, Data, Users, etc.) • As a next step, and following the conceptual model, the threats that can harm the system are identified and associated with the system assets. Then, the vulnerabilities related to the multimodal ecosystem are presented and associated with the threats, in order to form a triplet (asset, threat, vulnerability) that will be used for risk evaluation. • Instead of performing static risk analysis on use-case specific environments, it was decided to propose a dynamic risk analysis system based on the conceptual model that can be updated in realtime by external sources. The specific approach will be developed as part of the CitySCAPE framework and evaluated (WP5). • The cascading methodology is also integrated into the risk model with the use of fault-trees. • Finally, GDPR requirements and compliance was investigated defining the axes for the application development with respect to the rights of data owners (right to object storage/processing, right to be forgotten, right to restrict processing and more)
D2.1 CitySCAPE Use cases
Creators: name: Roberts, Andrew
name: Sell, Raivo
name: Liivar Luts
name: Maliatsos, Kosta
Publisher: name: Zenodo
Year: 2022
Subjects: #CitySCAPE #H2020 #usecases #multimodaltransport #cybersecurity

description: Deliverable 2.1 details the multimodal transportation ecosystem use-cases defined by the cities of Genoa, Italy and Tallinn, Estonia. The major concepts of multimodal transport covered in the use-case definition include: - Mobility-As-A-Service - Adaptive Traffic Control - Infomobility - Electronic and mobile ticketing These use-cases, whilst diverse, demonstrate a variety of multimodal transport scenarios which focus on the interaction of the passenger with the transportation platforms and supporting system assets. They present realistic scenarios which the cities have selected for their importance for protection against cyber threats. The transportation modes included in the use-cases are: - Bus - Tram - Trolley - Trains - Autonomous vehicle shuttle. These modes exhibit both conventional city transportation and new innovative platforms such as autonomous vehicle public transportation. An initial cyber threat scenario analysis has been provided, which will be updated from the results of risk modelling and vulnerability-threat analysis, the adopted system architecture, the pilot design and objectives, the types and methods of attack that may be demonstrated. Goals for the CitySCAPE solution were identified as: 1. Improve confidence in efficient handling of 0-day and denial-ofservice attacks. 2. Minimise security risks introduced by (less-security aware) external service providers. 3. Improve fraud protection. 4. Minimise risks to personal privacy related to fraud prevention and new ticketing services
Supplementary figures from Green greenhouse: leaf enclosure for fruit development of an androdioecious vine, Schizopepon bryoniifolius
Creators: name: Nagaoka, Nobuyuki
name: Naoe, Shoji
name: Takano-Masuya, Yu
name: Sakai, Shoko
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: Individual plants can produce leaves that differ substantially in size, morphology and many other traits. However, leaves that play a specific role in reproduction have rarely been reported. Here, we report leaves specialized to enclose fruit clusters and enhance seed production in an annual vine, Schizopepon bryoniifolius. Enclosure leaves were produced at the end of the growing season in late autumn. They were different in greenness and structure from other leaves. Under solar radiation, the ambient temperature inside an intact enclosure was up to 4.6°C higher than that near a fruit cluster whose enclosure leaves had been removed. We found that enclosures were thicker at colder sites. Removal of enclosing leaves negatively affected fruit survival and/or growth, but we could not identify the exact mechanism. The results suggested that enclosures allow the plant to produce seeds under the cold weather the plant encounters at the end of its life. Vegetative and reproductive traits of plants have usually been studied separately. This study indicates how they can dynamically interact, as shown by an examination of associations among leaf and reproductive trait changes according to life stages.
TESS Experiments: Public Opinion and Attributions for Health Care Costs
Creators: name: McCabe, Katherine
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Time-sharing Experiments for the Social Sciences (TESS) offers researchers the opportunity to capture the internal validity of experiments. Investigators submit proposals, and TESS fields successful proposals for free on a representative sample of adults in the United States. This experiment was conducted to examine the conditions under which individuals attribute their experiences to government or call on government to address their experiences. Respondents were randomly assigned to either a control condition or one of four treatment examples of individuals confronting unexpected healthcare costs which varied by reason (insurance refused coverage of services or provider charged more than expected) and inclusion of a contextual cue of the government conversation on healthcare (not included or included). A total of 2,016 respondents participated. Respondents answered measures of blame attribution and who, if anyone, they would contact about unexpected healthcare cost if they were faced with a similar situation. This allowed for comparison of average ranking of blame and the proportion of respondents contacting a given group or person between treatments.
Supplemental Methods, Figures and Tables from Personality composition determines social learning pathways within shoaling fish
Creators: name: Hasenjager, Matthew J.
name: Hoppitt, William
name: Dugatkin, Lee A.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Includes supplemental methods, figures, and tables
Ingest From Government Agencies (Pilot Definition: Pilot 3)
Creators: name: Oolu, Karin
name: Alföldi, István
name: Anderson, David
name: Anderson, Janet
Publisher: name: Zenodo
Year: 2018
Subjects: E-ARK
Pilot
Ingest from government agencies

description: This technical note sets out the definition of E-ARK Pilot 3: Ingest from government agencies.
title: The Yarmouk basin, an essential transboundary water resource
Creators: name: Siebert , Christian
name: Shalev , E.
name: Magri , F.
name: Möller , P.
name: Salameh , E.
name: Rödiger , T.
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The Yarmouk River is the primary tributary to the Jordan River and a strategic transboundary freshwater resource of Syria, Jordan, and Israel. In the past decades, the Yarmouk watershed has been extensively exploited by the riparian with the construction of dams including the Al-Wehda and Adassiyeh dams. The operation of the dams is guided by international water agreements between Jordan and Israel and Jordan and Syria and control the flux of the Yarmouk River. Repeated sampling over 16 years revealed variable flow paths towards certain wells over time as documented by variable REE-pattern and δ18O, δD and 87Sr/86Sr signatures of groundwater and lead to new insight with respect to sources of groundwater, their flow patterns and salinization in the Yarmouk basin. The conjoint interpretation of water table fluctuations indicate unexpected interactions of the river with the major groundwater resources of the entire region. 2D transient numerical simulations of coupled fluid flow and heat transport processes are used to investigate the impact of (i) a zone of hydraulic anisotropy and (ii) abstraction on hydraulic heads and temperature profiles in the shallow aquifers. The models support the geochemical indicated existence of a structural feature along the principle axis of the gorge, which hydraulically connects groundwaters in both flanks, while cross flow of groundwaters is prevented. That implies a subsurface anisotropic zone, which lets the gorge act as a complex conduit-barrier system where adjacent N-S and S-N flow-fields confluence and get drained towards the Jordan Rift.