cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From Cyanobacteria to Humans: Studying the Proteins Involved in the Core of the Circadian Rhythm
Creators: name: Apitz, Julia Marie
Publisher: name: Brandeis University
Year: 2026

description: Circadian rhythm plays an essential role in many biological processes. In cyanobacteria, circadian rhythm is regulated by three core proteins: KaiA, B, and C.1 KaiB is an example of a metamorphic protein, a protein that can adopt more than one conformation. In some systems, the circadian rhythm is regulated by KaiB and C, with KaiB binding to KaiC only in the fold-switch (FS) state.1 When not bound to KaiC, it exists in a ground state.1 It is estimated that roughly 0.5-4% of all proteins in the PDB are fold-switching proteins.2 Multiple sequence alignment (MSA) of known protein states can be used to predict the less likely state of metamorphic proteins using AlphaFold-2 (AF2).4,29 AF2 has become the most accurate tool to predict protein conformations but has lacked in predicting multiple conformations of metamorphic proteins.3 The Kern lab has shown that AlphaFold-cluster (AF-cluster), which utilizes MSA, can predict both states of KaiB.4 It was also used to find natural variants of KaiB that exist in the FS state. One such KaiB was that of T. elongatus vestitus (KaiBTV).4 In order to verify the FS state was the most populated conformation, I expressed and purified KaiBTV for verification of conformation using nuclear magnetic resonance (NMR).Casein Kinase I (CK1 is a serine/threonine kinase that maintains the core clock of the human circadian rhythm by phosphorylating its protein substrate, human Period protein 2 (hPER2).6-16 While most kinases are known for having fast activity, CK1phosphorylates hPER2 slowly in order to maintain the 24-hour circadian period.6-22 Phosphorylation of hPER2 allows it to be transported into the nucleus, along with Cryptochrome (CRY) and CK1, to regulate transcription of hPER2.6-16 While it is known that the Familial Advanced Sleep Phase (FASP) region interacts directly with the kinase, other interactions that might affect the affinity of hPER2 to the kinase are not fully understood. Understanding the mechanism of the interaction between CK1 with hPER2 would demonstrate how the two dictate the 24-hour circadian rhythm. There are many CK1 mutations defined in the literature that either shorten or lengthen the period but the mechanism by which some of these mutants alter the period is somewhat unknown.7,11,16,22 Period shortening mutations are found to be conserved in both CK1 and DBT, the Drosophila homolog of CK1.7,11,16,22 Seeing how these mutations affect affinity and phosphorylation kinetics would give information on how CK1 and hPER2 maintains the 24-hour period. Preliminary activity assay data suggests that the landing site of hPER2 leads to higher phosphorylation activity by CK1C, but more work needs to be done to verify that the landing site is crucial for phosphorylation of the FASP region.
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¼Ð¾Ð´Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð° Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾-Ð¸Ð·Ð»ÑÑÐ°ÑÑÐ¸Ñ Ð»Ð°Ð·ÐµÑÐ¾Ð² Ð·Ð° ÑÑÐµÑ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð²ÑÑ Ð¾Ð´Ð½Ð¾Ð³Ð¾ Ð·ÐµÑÐºÐ°Ð»Ð° ÑÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¸Ð¾Ð½Ð½ÑÐ¼ Ð¿ÑÑÐºÐ¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Vertical-cavity surface- emitting laser modes are formed by an ion beam-milled output coupler
Creators: name: ÐÑÐ»Ð°ÐµÐ², ÐÐ½Ð´ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾-Ð¸Ð·Ð»ÑÑÐ°ÑÑÐ¸Ð¹ Ð»Ð°Ð·ÐµÑ
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Ð²ÑÑ Ð¾Ð´Ð½Ð¾Ðµ Ð·ÐµÑÐºÐ°Ð»Ð¾ Ð»Ð°Ð·ÐµÑÐ°
vertical-cavity surface-emitting laser
modes composition
direct focused ion beam lithography
output coupler

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð° Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¸Ð¾Ð½Ð½ÑÐ¼ Ð¿ÑÑÐºÐ¾Ð¼ Ð½Ð° Ð²ÑÑÐ¾Ð´Ð½Ð¾Ðµ Ð·ÐµÑÐºÐ°Ð»Ð¾ Ð»Ð°Ð·ÐµÑÐ° Ñ ÑÐµÐ»ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐµÐ³Ð¾ Ð¼Ð¾Ð´Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð°. ÐÑÐ»Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾-Ð¸Ð·Ð»ÑÑÐ°ÑÑÐ¸Ñ Ð»Ð°Ð·ÐµÑÐ¾Ð², Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð°Ñ Ð½Ð° Ð¾ÑÑÐ»ÐµÐ¶Ð¸Ð²Ð°Ð½Ð¸Ð¸ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð² Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ°Ñ Ð»Ð°Ð·ÐµÑÐ° Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐµÐ³Ð¾ Ð²ÑÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð·ÐµÑÐºÐ°Ð»Ð° ÑÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¸Ð¾Ð½Ð½ÑÐ¼ Ð¿ÑÑÐºÐ¾Ð¼.Â  Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ ÑÐ²Ð»ÑÐµÑÑÑ Ð±ÑÑÑÑÑÐ¼, Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½ÑÐ¼ Ð¸ Ð½Ð°Ð³Ð»ÑÐ´Ð½ÑÐ¼ ÑÐ¿Ð¾ÑÐ¾Ð±Ð¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾-Ð¸Ð·Ð»ÑÑÐ°ÑÑÐ¸Ñ Ð»Ð°Ð·ÐµÑÐ¾Ð²Â  Ð² Ð±Ð»Ð¸Ð¶Ð½ÐµÐ¼ Ð¿Ð¾Ð»Ðµ.
description: The work is devoted to studying the method of influencing a laser output mirror with a focused ion beam in order to change its mode composition. A technique for studying vertical-emitting lasers was developed based on tracking changes in the optical characteristics of the laser as a result of changing its output mirror with a focused ion beam. The developed method is a fast, informative, and visual way to study the distribution of the radiation intensity of vertical-emitting lasers in the near field.
Signal processing for multiple receive antenna systems in the presence of multiple access interference
Creators: name: Salam, Naser
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: In wireless communications systems employing DS-CDMA, the base stations with multiple antennas receive signals from different mobiles that are affected by fading and noise as well as interference from other users, thus diminishing the capacity. This dissertation considers a base station with multiple receive antennas which are weighted spatially by using maximal ratio combining. Moreover, at the transmitter side, the thesis examines the use of pilot signals along with the data stream for channel estimation purpose. For each user, the pilot signals are transmitted in parallel with the data signal using orthogonal signature waveforms to those of the data signal. The proposed receiver in this thesis uses a decorrelator detector to not only to decorrelate the data signal from the MAI components, but also to decorrelate the pilot signal to achieve good channel gain estimation. The study shows that the proposed system has a good resistance toward the near-far problem, give good space receiver performance efficiency comparing it with conventional space receivers and it has Less power assigned to the pilot power stream to obtain best channel estimation within a certain fading rate.
Integrated Pest Management, 2022 Quarter 4 Newsletter
Creators: name: Washington State University Extension
Publisher: name: Washington State University
Year: 2022

description: Highlights include:
description: In-state and international IPM outreach
description: Entomological societies “JAM” with joint meeting
description: Spotted lanternfly videos produced
description: Wheat Academy and podcasts for grain growers
description: BDMs aid in IPM and crop success
description: AgWeatherNet expands on Olympic Peninsula
description: Nematodes, rootstocks are hot topics in grapes
description: Focus on seedcorn maggot control
Inferring the population properties of binary neutron stars with gravitational-wave measurements of spin
Creators: name: Zhu, Xingjiang
name: Thrane, Eric
name: Oslowski, Stefan
name: Levin, Yuri
name: Lasky, Paul D.
Publisher: name: Swinburne
Year: 2024

description: The recent LIGO-Virgo detection of gravitational waves from a binary neutron star inspiral event GW170817 and the discovery of its accompanying electromagnetic signals mark a new era for multimessenger astronomy. In the coming years, advanced gravitational-wave detectors are likely to detect tens to hundreds of similar events. Neutron stars in binaries can possess significant spin, which is imprinted on the gravitational waveform via the effective spin parameter chi(eff). We explore the astrophysical inferences made possible by gravitational-wave measurements of chi(eff). First, using a fiducial model informed by radio observations, we estimate that approximate to 15-30% of binary neutron stars should have spins measurable at greater than or similar to 90% confidence level by advanced detectors assuming the spin axis of the recycled neutron star aligns with the total orbital angular momentum of the binary. Second, using Bayesian inference, we show that it is possible to tell whether or not the spin axis of the recycled neutron star tends to be aligned with the binary orbit using greater than or similar to 30 detections. Finally, interesting constraints can be placed on neutron star magnetic field decay after greater than or similar to 300 detections, if the spin periods and magnetic field strengths of Galactic binary neutron stars are representative of the merging population.
Risk Factors for Addiction and Their Association with Model-Based Behavioral Control
Creators: name: Reiter, Andrea M. F.
name: Deserno, Lorenz
name: Wilbertz, Tilmann
name: Heinze, Hans-Jochen
name: Schlagenhauf, Florian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: decision-making
subject: instrumental control
subject: addiction
subject: alcohol
subject: family history
subject: risk
subject: impulsivity
subject: cognitive capacity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Addiction shows familial aggregation and previous endophenotype research suggests that healthy relatives of addicted individuals share altered behavioral and cognitive characteristics with individuals suffering from addiction. In this study we asked whether impairments in behavioral control proposed for addiction, namely a shift from goal-directed, model-based toward habitual, model-free control, extends toward an unaffected sample (n = 20) of adult children of alcohol-dependent fathers as compared to a sample without any personal or family history of alcohol addiction (n = 17). Using a sequential decision-making task designed to investigate model-free and model- based control combined with a computational modeling analysis, we did not find any evidence for altered behavioral control in individuals with a positive family history of alcohol addiction. Independent of family history of alcohol dependence, we however observed that the interaction of two different risk factors of addiction, namely impulsivity and cognitive capacities, predicts the balance of model-free and model-based behavioral control. Post-hoc tests showed a positive association of model-based behavior with cognitive capacity in the lower, but not in the higher impulsive group of the original sample. In an independent sample of particularly high- vs. low-impulsive individuals, we confirmed the interaction effect of cognitive capacities and high vs. low impulsivity on model-based control. In the confirmation sample, a positive association of omega with cognitive capacity was observed in highly impulsive individuals, but not in low impulsive individuals. Due to the moderate sample size of the study, further investigation of the association of risk factors for addiction with model-based behavior in larger sample sizes is warranted.
The Politics of Love: The “Enthusiasts” and Feminism in Nineteenth-Century Poland
Creators: name: Cornett, Natalie Nikkole
Publisher: name: Brandeis University
Year: 2027
Subjects: East Central Europe
Feminism
Gender
Nineteenth Century
Poland
Women's History
Women's Studies
Nationalism

description: The decades between Poland’s two great uprisings (in 1830-1831 and 1863) were marked by imperial repression of Polish cultural and political life. Polish intellectual circles nevertheless flourished at home and abroad, albeit covertly. Narcyza Żmichowska led a group of educated women known as the “Enthusiasts” (Entuzjastki), who were united by their commitment to live as independent women despite the intense nationalism that put the nation above all—including class and gender. The Enthusiasts emphasized sororal love and homosocial bonding in their program to contest both an oppressive imperial regime and constrictive gender roles. Their affective relationships with each other, as well as the decision to remain unmarried, childless or divorced, violated accepted conventions and, especially, the patriotic emphasis on the Polish family. This dissertation draws upon a large corpus of letters, diaries, police files, and published works from across Europe; it examines the Enthusiast movement from its emergence in the 1840s to the death of its most notorious public figure and writer, Narcyza Żmichowska, in 1876. The project demonstrates how Polish women appropriated and contributed ideas about women’s emancipation, nationalism and religion in a globalizing era of increasing literacy and transnational exchange. It shows how the Polish intelligentsia was so monomaniacally focused on the national question and the struggle for independence that discussion of other social questions was dismissed as “unpatriotic.” Polish nationalists demanded that women do their part by remaining at home and raising children to love and sacrifice for the fatherland. When Polish women acted outside of these precepts, as did the Enthusiasts, they met with derision despite their explicit support for the national cause. This study emphasizes the limitations of nationalism as a binding agent, especially for those dismissed as socially deviant. It contributes to debates on feminism and nationalism and makes a critical contribution to the field of European women’s history.
Magneto-plasmons in optical slab waveguides
Creators: name: Scales, Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: The effect of an externally applied magnetic field on the propagation characteristics of a plasmon-polariton wave supported by an infinitely wide thin metal waveguide was investigated. In order to do so, the dispersion relation was derived, from Maxwell's equations, enabling accurate modelling of the situation of interest. The general dispersion relation, including the constraint equation, for magneto-plasmons was derived in general, and then, specifically for a magnetic field applied along three orthogonal cartesian axes. The losses in the metal were included in the dispersion equation so that a better understanding of the influence of an externally applied magnetic field may be provided. The dispersion relation is used as the basis of a software model of magneto-plasmons in thin metal films. This model is validated against specific cases in the literature with and without an externally applied magnetic field. The specific formulations in the literature were deemed to be incorrect, and have been corrected and the results have been interpreted. The model is then used to simulate thin gold films bounded by silicon dioxide at an infrared wavelength. The modelling results include the effect of the externally applied magnetic field on the propagation constant and the corresponding field components for all three Cartesian orientations of externally applied magnetic field. The results from these simulations are presented and interpreted. (Abstract shortened by UMI.)
“No Evil Shall Escape My Sight”: The Comic Book Industry & Social Relevance in the 1970s
Creators: name: Kemp, Austin H
Publisher: name: Brandeis University
Year: 2020
Subjects: Comics Code Authority
Comics Studies
Politicization
Underground Comix
Cultural or Population Studies
Rhetoric

description: The comic book industry in the 1970s produced the first mainstream superhero comic to utilize social commentary and character revisionism. Denny O’Neil and Neal Adams’ Green Lantern/Green Arrow: Hard Traveling Heroes addresses the milieu of the 70s and is analyzed alongside documentary evidence to create connections between the textual narrative and social events. The narrative’s use of character iconography divorces its title heroes from their traditionally conservative ideologies. The dialectical relationship between iconography and ideology create an overall picture of innovation in the industry. It also denotes a generational shift in ideology that reflects the change in cultural values between the ‘60s and ‘70s.
Adsorption of nitrogen, methane, and carbon monoxide on aluminosilicate and aluminophosphate molecular sieves.
Creators: name: Predescu, Ligia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Engineering, Chemical.

description: Considering the difficulties associated with the experimental determination of binary mixture adsorption isotherms, pure-gas adsorption information becomes vital in the prediction of these isotherms and the corresponding phase equilibria necessary in the design of adsorptive separation units. Experimental equilibrium isotherms describing the adsorption of pure N$\rm\sb2,\ CH\sb4,$ and CO in a natural aluminosilicate molecular sieve (clinoptilolite from Cuba) and two synthetic small-pore aluminophosphate molecular sieves (AlPO$\sb4$-17 and AlPO$\sb4$-18) have been determined using the volumetric method at 40$\sp\circ$C over a pressure range up to about 1000 mm Hg, and subsequently fitted with the Langmuir and Flory-Huggins Vacancy Solution Theory equations. Additional Langmuir and FH-VST fits of equilibrium isotherms previously measured over the same pressure range at room temperature and 40$\sp\circ$C to describe the equilibrium adsorption of the same three adsorbates in two aluminosilicate molecular sieves (natural clinoptilolite from Turkey and zeolite 5A), as well as in a medium-pore aluminophosphate molecular sieve AlPO$\sb4$-11 were also obtained. The Freundlich equation was found to yield a better fit than either the Langmuir or FH-VST equations for the experimental adsorption isotherms of N$\sb2$ and CO on AlPO$\sb4$-17. The higher observed capacities of the aluminosilicate molecular sieves, compared to the aluminophosphates, were attributed to the energetic heterogeneity conferred by the presence of framework-charge compensating cations. The model parameters obtained by fitting the experimental pure-component adsorption isotherms permitted the prediction of the mixture adsorption phase diagrams and the binary adsorption isotherms by the Extended Langmuir Model and the Flory-Huggins Vacancy Solution Model for the three possible binary mixtures at 101.3 kPa total pressure and the pure-component adsorption temperatures investigated. The Ideal Adsorbed Solution Theory was also applied with the explanation of the behaviour predicted by each model for each adsorption system was attempted. (Abstract shortened by UMI.)
The functions of thev-rel oncogene product of reticuloendotheliosis virus, REV-T.
Creators: name: Park, Mahnhoon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Microbiology.

description: v-rel is the transforming gene of the avian reticuloendotheliosis virus, strain T (REV-T), which causes fatal lymphomas in young birds and also transforms avian lymphoid cells in vitro. The v-rel oncogene codes for a protein of 503 amino acids. The v-rel protein exhibits extensive homology within its N-terminal 300 amino acids with several mammalian $\kappa$B enhancer binding proteins including 50-kDa and 65-kDa subunits of NF-$\kappa$B transcription factor. In this study, an array of biochemical functions of mutant v-rel proteins was investigated in order to understand the mechanism of transformation by v-rel oncogene. Since the v-rel protein shows striking homology with NF-$\kappa$B subunits, wild-type v-rel or deletion and linker insertion mutants of v-rel were expressed in insect cells to determine the $\kappa$B-specific DNA binding activity. C-terminal deletions of up to 100 amino acids, or deletion of 11 N-terminal amino acids had no effect on DNA binding activity of v-rel protein, whereas N-terminal deletion of 99 amino acids abolished DNA binding activity completely. All of the mutant v-rel proteins with transforming activity also retained the DNA binding activity like wild-type v-rel protein, whereas all of the mutant v-rel proteins which were nontransforming lost DNA binding activity. Therefore, it is clear that the $\kappa$B-specific DNA binding activity is necessary for transformation by v-rel. All of the non-DNA binding, non-transforming mutants of v-rel exhibited a transdominant negative effect. These results suggest that the formation of DNA binding complexes by v-rel protein with NF-$\kappa$B subunits is necessary for transformation. In order to determine the possible role of pp40 association in transformation, pp40 association with v-rel protein was examined. Association of pp40 with the DNA binding mutant v-rel proteins including wild-type v-rel protein resulted in inhibition of DNA binding activity. These results imply that the physical association with pp40 itself might not be sufficient for transformation by v-rel. Since the v-rel protein directly binds to the $\kappa$B site, the $\kappa$B-dependent transcriptional activity of v-rel protein was investigated. The non-DNA binding, non-transforming mutants function as transdominant inhibitors of the rel family of transcription factors. These results support a model in which activation of gene expression directly by v-rel protein is required for its ability to induce oncogenic transformation. (Abstract shortened by UMI.)
Electrochemical study of the thermal stability of alkanethiols adsorbed on gold (111).
Creators: name: Al-Maznai, Hassan Mohamed.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Chemistry, Inorganic.

description: Organic thiols adsorb on metallic surfaces and form so-called self-assembled monolayers (SAMs). These interfacial systems have attracted a lot of attention because of their possible use in various technologies such as electrochemical sensors, organic conductors or corrosion inhibitors. These applications make use of the ability of thiols to prevent charge transfer between the metal surface and the electrolyte solution. However, organic materials can undergo phase transitions in the range of temperature where modified electrodes are used. Few studies have been done on the thermal stability of molecular films. This thesis is a study of the electrochemical properties of alkanethiols chemisorbed on Au(111) between 5°C and 60°C. We found that soluble alkanethiols are reduced in a single step. We found that insoluble alkanethiols are reduced in two steps. The reduced products (thiolates) are insoluble and thus remain physisorbed at the electrode surface. They can be oxidatively redeposited when the potential is scanned in the positive direction. The development of a fine structure in the voltammogram of insoluble thiols is shown to be caused by the low solubility of the thiols. We propose a model in which the reductive desorption and the oxidative redeposition processes proceed through the same two-step mechanism. We have studied the effect of temperature on insoluble thiols that can be induced, by the application of an electric field, to reversibly go from a chemisorbed state to a physisorbed state. We found that the physisorbed thiolates remain at the electrode surface at temperatures as high as 70°C. Our results reveal a change in the reductive desorption/oxidative redeposition at 23°C. We assign this change to an order-disorder transition. The ion blocking properties of insoluble thiols were studied with differential capacitance and with cyclic voltammetry using ferricyanide as a redox probe. We found that monolayers with low numbers of defects are formed after a single incubation in a solution of thiols. Multiple incubations in a solution of thiols give a monolayer with such an extremely low number of defects that electron transfer occurs via tunneling. Finally, we determined the oxidation mechanism of adsorbed butanethiol in neutral and alkaline aqueous solutions. Under neutral conditions, the butanethiols are oxidized via a nine electrons process, whereas in alkaline solutions, the oxidation is greater and requires thirteen electrons. These results are found to be related to the greater electrocatalytic activity of gold in alkaline solutions. (Abstract shortened by UMI.)
Conscience et connaissance expérientielle : le rôle des affects dans la progression éthique chez Spinoza.
Creators: name: Charles, Syliane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Philosophy.

description: La double question à la source de ce travail est la suivante: comment le mécanisme du progrès dans la connaissance se déploie-t-il exactement chez Spinoza, et pourquoi ce processus cognitif , relié aux idées qu'on possède, est-il en même temps un processus éthique , relié à la joie et au bonheur? On constate que le champ de l'éthique n'est pas, à proprement parler, celui de la connaissance, mais celui du progrès dans la connaissance, qui s'achève par une conscience supérieure de soi, de Dieu et des choses. Nous avons donc cherché à comprendre précisément ce que la notion de «conscience» recouvrait, savoir, une connaissance d'un état de puissance du sujet, une «connaissance expérientielle» ou affective, et quelle place elle avait dans l'économie du système: celle de moteur du progrès quasi automatique de l'âme humaine. Chez l'homme, c'est la conscience de soi donnée dans les affects qui permet le progrès éthique, sachant qu'à chaque stade de ce progrès correspond simultanément un degré ontologique de puissance, un degré d'activité dans la connaissance, et un degré de joie. Ontologie, théorie de la connaissance et théorie des affects sont si inextricablement mêlés dans l'éthique de Spinoza qu'il est impossible de rendre compte proprement de celle-ci sans utiliser les trois, ce que nous avons tenté de faire par le plan choisi. Un premier chapitre s'attache à comprendre la causalité à l'oeuvre dans la nature; un deuxième présente la théorie spinoziste de l'âme; un troisième trace les contours d'une ontologie des affects; et un quatrième enfin unifie ces trois dimensions en montrant comment l'affectivité explique à chaque degré de la progression le passage à un degré supérieur. Au terme de cette étude, nous pensons pouvoir comprendre avec une ampleur plus grande le sens même de l'éthique en même temps que ses bornes. Ni en deçà du progrès (les animaux), ni au-delà (Dieu): l'affectivité concerne l'homme, et c'est l'homme aussi qui est concerné par l'éthique. Car ce sont très précisément les affects qui, à chaque étape de l'existence, guident l'âme jusqu'à la réalisation de sa puissance propre, la faisant ainsi progresser vers la béatitude.
Using DP-constraints to obtain improved TSP solutions.
Creators: name: Vella, Danielle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Computer Science.

description: The Travelling Salesman Problem (TSP) is a well-known NP-hard problem. Although it is unlikely that an efficient algorithm will ever be found for the TSP, some success has been achieved for large real-world instances by using the branch and cut technique. This technique requires knowledge of classes of useful valid inequalities for the polytope associated with the TSP, as well as efficient separation routines for these classes of inequalities. The DP-constraints are a recently discovered class of valid inequalities for the TSP which contain the famous comb inequalities. An efficient separation routine is known for these constraints if certain conditions are satisfied by the point to be separated. This separation routine has never been implemented or tested. We present several performance enhancements that we made to the existing separation routine for these constraints and discuss our implementation of this improved algorithm. Our implementation runs in O(n3 lg n), where n is the number of vertices in the graph. We also show how the outcome of the separation routine can be translated into a DP-constraint that is in a suitable form for testing. We test our implementation and provide results that we believe show the usefulness of these inequalities and the separation routine within a branch and cut framework for the TSP.
Effects of Age and Hearing Acuity on Self-Paced Listening: A Pilot Study
Creators: name: Lash, Amanda
Publisher: name: Brandeis University
Year: 2010

description: This present study investigated spoken sentence processing as a function of age and a variety of hearing acuities via a self-paced listening paradigm. Young adults and older adults with clinically normal hearing and with mild-to-moderate hearing loss, self-paced through spoken sentences using an auditory moving window technique. Sentences varied in syntactic complexity (subject-relative, objective-relative) and sound level of presentation (high, low). Accuracies and mean pause durations were recorded. An omnibus ANOVA revealed significant main effects of sound level, sentence type and segment position. These effects were moderated by a significant Sentence Type X Segment Position X Age interaction. Results were taken as support of syntactic knowledge preserved in normal aging. Furthermore, we found that a low sound level of 15 dB above individual's speech-reception threshold produced comparable pacing patterns to a conversational speaking level. However, results showed that in the low sound level condition participants increased their mean pause times. In addition, in the low sound level, comprehension accuracies suffered for older adults with poor hearing.
Reassessing Stress: Distinct Neural and Mental Health Correlates of Stress Exposure and Controllability Appraisals
Creators: name: Fassett-Carman, Alyssa
Publisher: name: Brandeis University
Year: 2021
Subjects: Adolescence and emerging adulthood
Depression
Development
Gray matter
Learned helplessness
Stress appraisals
Brain
Child or Adolescent Mental Health
Neuroanatomy
Neuroscience

description: Stress is a strong risk factor for internalizing symptoms and can lead to changes in gray matter (GM) structure associated with psychopathology. Adolescence and emerging adulthood is a time of heightened stress, onset of stress-related disorders such as depression, and GM development, and is thus posited to be a sensitive period for the effects of stress. However, not all youth who experience stress develop symptoms. Learned helplessness theory and evidence describes how having control over stressful experiences can protect against negative affective and neural outcomes of life stress. However, despite research demonstrating this protective effect in rodent models and with acute-stress paradigms in humans, it is unknown how perceived control over real life stressors relates to internalizing symptoms (depression and anxiety). Further, little is known about the neural correlates of exposure to and perceived control over life stress humans. I present four studies, each corresponding to a chapter, that address these gaps. All studies use adolescent and emerging adult samples to capture this period of heightened risk. Chapters 1 and 2 demonstrate that perceived lack of control over life stressors is associated with depression symptoms in community and clinical samples, and that this relation is distinct from the risk conferred by amount of stress exposure. Chapters 3 and 4 demonstrate that frequency of life stress exposure and perceived control over life stressors have distinct gray matter correlates. Greater perceived control over life stress is associated with GM thickness in the frontoparietal control network (FPCN) and gender-specific associations with GM in the medial prefrontal cortex and amygdala. Conversely, relations between the frequency of stress exposure and GM thickness and surface area were all gender-specific, with opposite directions of effects seen for male and female youth in the FPCN, default mode network, and limbic regions for GM thickness, and default mode network (DMN) and dorsal attention network regions for surface area. These findings suggest that appraisals of control may shape clinical and neural stress outcomes in humans although these relations should be tested longitudinally to determine temporal precedence, and that testing for gender differences is crucial to understanding the neural impact of life stress.
Practice Approaches to Solo Repertoire for Beginner Tubists
Creators: name: Harding, Bryson
Publisher: name: Washington State University
Year: 2022
Subjects: Music
Music Education

description: This document serves as a free resource to beginner tubists who are not able to afford private instruction and want to improve their approach to solo repertoire. I chose three solos from the Concert and Contest Collection book to showcase my practice methods and how I approach learning new music. These pieces have been selected because they demonstrate stylistic differences between eras in music such as Baroque, Classical, and Contemporary and because many all-state auditions use this book. I have used colloquial and familiar language throughout this document as this is intended for a youth-intended audience.
MOTIVATIONS OF UNETHICAL BEHAVIOR
Creators: name: Bates, Jay T.
Publisher: name: Washington State University
Year: 2024
Subjects: unethical behavior

description: This three-essay dissertation serves to better understand what motivates employee unethical behavior and what organizations can do to limit unethical behavior. Essay one explores how external factors such as long-term orientation and ethical work climate may influence the behavior of narcissistic employees. It tests whether these factors mitigate the tendency of narcissistic individuals towards unethical behavior through moral disengagement. The findings suggest that when narcissistic employees have a long-term orientation and are in an ethical work climate, their unethical behavior decreases. This challenges the notion that narcissists are solely driven by short-term motives and identifies some conditions under which the negative effects of narcissists may be attenuated. This essay contributes to both the unethical behavior and individual differences literatures.
description: Essay two investigates the factors influencing individuals to engage in unethical behaviors that benefit their organization. It adapts a model of moral decision-making and extends it to other decision-making contexts. The study examines parallel models involving moral, prosocial, and selfish schemas. Through an online scenario-based experiment with 355 participants, it identifies that moral awareness reduces while selfish awareness increases the likelihood of engaging in unethical pro-organizational behaviors (UPBs). Surprisingly, selfish awareness drives UPB engagement more than prosocial awareness does. This research enriches the UPB literature by considering schema-type awareness and contributes to the moral decision-making literature by exploring various decision-making schemas.
description: Essay three investigates how perceptions of workplace ethics relate to ethical behavior when considering the influence of contextual factors. It applies contingency theory to examine how perceptions of ethical priorities, known as ethical work climate (EWC), interact with cultural values and job context variables. Through meta-analysis, the study finds that in societies with higher power distance, EWC perceptions have a stronger positive association with ethical behavior, while in contexts with greater job autonomy, this positive association weakens. The role of collectivism as a contextual moderator shows mixed results. Surprisingly, the consequences of errors in work contexts do not influence the association between EWC perceptions and ethical behavior. Overall, this study underscores the importance of organizational context in shaping the impact of EWC perceptions on ethical behavior.
The experience of trauma resuscitation in the emergency department: A patient perspective.
Creators: name: O'Brien, Jo-Anne Elizabeth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Health Sciences, Nursing.

description: Traumatic injury occurs without warning leaving no time to prepare. The patient may be frightened about the unknown, their future, or the prognosis. The patient arrives in the Emergency Department (ED) where assessment and management of injuries begins. Little is known about the patient's experience of trauma resuscitation. Therefore, a qualitative study using interpretive phenomenology was undertaken to describe the lived experience of trauma resuscitation in the ED. A total of seven participants were interviewed after they experienced trauma resuscitation in the ED of a Lead Trauma Hospital. Tape-recorded interviews were conducted on the in-patient Trauma Unit between day 2 and day 7 post trauma resuscitation. Follow-up interviews were conducted with four participant's seven to twelve months after the initial interview. Data analysis utilized Colaizzi's eight-step analytical process. Four themes were revealed in the data analysis: I Remember, I Was Scared, I Felt Safe, and I Will Be OK. The findings also revealed that initial perceptions of vulnerability subsided as a sense of feeling safe became prominent. System factors were acknowledged to influence the overall conviction that it was a positive experience. Lastly, nursing interventions were important in contributing to the participants' feelings of being safe. This suggests that comfort care measures need to be at the forefront of trauma nursing care as well as measures aimed at attaining physiological stability.
What do new Australian higher education teachers value in a teaching induction MOOC
Creators: name: Fraser, Kym
name: Clarke, Linden
Publisher: name: Swinburne
Year: 2024

description: Contemporary approaches to university teachingis a free online MOOC which was designed to provide
‘just in time, just for me’ teaching induction for those new to teaching in the higher education sector.
The introductory topics were selected in light of a literature review and research on the topics provided in current Australian university induction programs (Fraser et. al. under review). Specialty topics such as Teaching mathematics, Work Integrated Learning, Sessional Staff, Your Professional Well Being, and Politics of Australian Higher Education are also included. Each introductory module is designed to take two hours of engagement, while also providing extension work. While structured to be taken one module a week, across the semester, participants can pick and choose the modules at a time that suits their needs and experience. The MOOC has been developed for any HE member who teaches, including sessional, contract and continuing academics, librarians and IT staff. This showcase presents an analysis of the data from the semester 2, 2017 pilot. The analysis provides a snapshot of: the modules the participants engaged in; what they specifically valued about those modules; and their suggestions for ways in which the modules could be improved.
Moreh Steiner and Melech David: Teaching Psalms through a Waldorf Perspective
Creators: name: Heilbron, Micah Rose
Publisher: name: Brandeis University
Year: 2024
Subjects: Psalms
Jewish Education
Waldorf Education
Bible Education
Jewish Literacy
Curriculum
Pedagogy
Rudolf Steiner
Literacy
Child Development

description: Applying Waldorf pedagogy to Jewish Bible education with Psalms 23, 126, and 150.
title: ÐÐ¾ÑÑÑÐ¾ÐµÐ½Ð¸Ðµ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐ²ÐµÑÑ Ð½Ð¸Ð·ÐºÐ¾ÑÐ°ÑÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°ÐºÑÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð»ÑÑÐ°ÑÐµÐ»Ñ Ð¼Ð°Ð»ÑÑ Ð²Ð¾Ð»Ð½Ð¾Ð²ÑÑ ÑÐ°Ð·Ð¼ÐµÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Construction of a mathematical model of an ultra-low-frequency electrodynamic acoustic transducer of small wave sizes
Creators: name: ÐÑÑÐ¸Ð½, ÐÐ¼Ð¸ÑÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ²ÐµÑÑ Ð½Ð¸Ð·ÐºÐ¾ÑÐ°ÑÑÐ¾ÑÐ½ÑÐµ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ñ
ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¸Ð·Ð»ÑÑÐ°ÑÐµÐ»Ñ
Ð°ÐºÑÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÑÐµÐ´Ð°
Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ñ
Ð´Ð°Ð²Ð»ÐµÐ½Ð¸Ðµ
ultra-low frequency oscillations
electrodynamic emitter
acoustic medium
harmonic oscillations
pressure

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ñ ÑÐ°ÑÑÐ¾ÑÐ½Ð°Ñ Ð¸ Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð°Ñ Ð¾Ð±Ð»Ð°ÑÑÐ¸ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸ÑÂ  Ð²Ð¾Ð·Ð¼ÑÑÐµÐ½Ð¸Ñ, Ð·Ð°Ð´Ð°Ð²Ð°ÐµÐ¼Ð¾Ð³Ð¾ Ð½Ð° Ð³ÑÐ°Ð½Ð¸ÑÐµ Ð°ÐºÑÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð»ÑÑÐ°ÑÐµÐ»Ñ. ÐÐ¾ÑÑÑÐ¾ÐµÐ½Ñ ÐºÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½ÑÐµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð´Ð»Ñ Ð¿Ð»Ð¾ÑÐºÐ¾Ð¹ Ð¸ Ð¾Ð±ÑÐµÐ¼Ð½Ð¾Ð¹ Ð¿Ð¾ÑÑÐ°Ð½Ð¾Ð²Ð¾Ðº Ð·Ð°Ð´Ð°ÑÐ¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ ÑÐµÑÐ°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: 1. ÐÐµÑÐµÐ´Ð°ÑÐ° Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð°ÐºÑÑÑÐ¸ÑÐµÑÐºÑÑ ÑÑÐµÐ´Ñ Ð¿ÑÐ¸ Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¼ ÑÐ°ÑÑÐµÑÐµ; 2. ÐÐ°Ðº ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÑÐµÑÑÑ Ð´Ð°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð²Ð¾ Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð² Ð°ÐºÑÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐµÐ´Ðµ Ð¿ÑÐ¸ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¸ Ð½Ð° ÑÑÐµÐ´Ñ ÐºÐ¸Ð½ÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¸ ÑÐ¸Ð»Ð¾Ð²ÑÐ¼Ð¸ Ð½Ð°Ð³ÑÑÐ·ÐºÐ°Ð¼Ð¸; 3. ÐÐ°Ðº ÑÐ¾Ð¾ÑÐ½Ð¾ÑÑÑÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ Ð·Ð°Ð´Ð°ÑÐ¸.
description: In this work, the frequency and time domains of propagation of a disturb-ance set at the boundary of an acoustic radiator were studied. Finite element models for flat and volumetric problem statements are constructed, as well as an analytical model is constructed. During the work, the following tasks were solved: 1. Transmission of effects on the acoustic environment during harmonic calculation; 2. How is the pressure distributed in the time domain in an acoustic medium when exposed to the medium by kinematic and force loads; 3. How do the electrodynamic and mechanical parameters of the problem relate.
Examining patient preferences in the treatment of rheumatoid arthritis using a discrete-choice approach
Creators: name: Alten, Rieke
name: Krüger, Klaus
name: Rellecke, Julian
name: Schiffner-Rohe, Julia
name: Behmer, Olaf
name: Schiffhorst, Guido
name: Nolting, Hans-Dieter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: rheumatoid arthritis
subject: disease-modifying antirheumatic drugs
subject: patient preferences
subject: discrete-choice experiment
subject: best–worst scaling
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Biological disease-modifying antirheumatic drugs (bDMARDs) used in second-line treatment of rheumatoid arthritis (RA) are administered parenterally. However, so-called targeted synthetic DMARDs (tsDMARDs) – developed more recently – offer alternative (ie, oral) administration forms in second-line treatment. Since bDMARDs and tsDMARDs can be regarded as equal in terms of efficacy, the present study examines whether such characteristics as route of administration drive RA patients’ treatment choice. This may ultimately suggest superiority of some second-line DMARDs over equally effective options, at least according to RA-patient preferences. Objective: The current study assessed the importance of oral administration among other treatment characteristics differing between available second-line DMARDs for RA patients’ preferences using a discrete-choice experiment (DCE). Materials and methods: The DCE involved scenarios of three hypothetical treatment options in a d-efficient design with varying levels of key attributes (route and frequency of administration, time till onset of drug effect, combination therapy, possible side effects), as defined by focus groups. Further patient characteristics were recorded by an accompanying questionnaire. In the DCE, patients were asked to choose best and worst options (best–worst scaling). Results were analyzed by count analysis and adjusted regression analysis. Results: A total of 1,588 subjects completed the DCE and were eligible for final analyses. Across all characteristics included in the DCE, “oral administration” was most desired and “intravenous infusion” was most strongly rejected. This was followed by “no combination with methotrexate” being strongly preferred and “intake every 1–2 weeks” being strongly rejected. On average, levels of route of administration showed strongest influences on patients’ decisions in post hoc bootstrapping analysis. Conclusion: According to the results, an oral DMARD that does not have to be combined with methotrexate and is not administered (only) every 1–2 weeks appears a highly favorable treatment option for patients with RA. DMARDs meeting these preferences may increase compliance and adherence in RA treatment.
Applied Science, Politics and Power: A conversation between Robert Bud and Sir Geoff Mulgan
Creators: name: Bud, Robert
name: Mulgan, Geoff
Publisher: name: Science Museum Group
Year: 2025
Subjects: museum studies
science diplomacy
politics
applied science

description: ‘Applied Science, Politics and Power’ was a conversation held at the Science Museum on 22 May 2024, between Robert Bud and Sir Geoff Mulgan. The discussion was moderated by the former BBC journalist Deborah Cohen and introduced by Scott Anthony. The event was organised under the auspices of the Museums and Industry: Long Histories of Collaboration project, with its interest in understanding the historical impacts of changing patterns of commercial and state patronage of science, technology, and museums of science and technology. In Bud’s address he discussed the rise and fall of applied science, linking its fortunes with a larger story of political economy: applied science provided liberal politicians with an acceptable way of intervening in the economy without seeming to intervene in the economy. Sir Geoff argued that governing might increasingly be thought of as and applied science that not only requires high levels of scientific knowledge among policy makers but also the existence of scientists with the training and confidence to go beyond offering ‘disinterested’ domain specific advice. They go on to discuss how to design (and staff) institutions able to synthesise scientific and political knowledge, whether the decline in scientific productivity is reversible or not, and how the dominance of biomedical research impacts the funding of science and public perceptions of progress. They also address the role of museums in synthesising public understandings of scientific and technological research.