cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches
Creators: name: Yadav, Rakhi
name: Chandrabose Selvaraj
name: Murali Aarthy
name: Prateek Kumar
name: Ankur Kumar
name: Singh, Sanjeev Kumar
name: Rajanish Giri
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Zika virus (ZIKV), belongs to the flavivirus genus and Flaviviridae family that associated with serious diseased conditions like microcephaly and other neurological disorders (Guillan–Barré syndrome). As there is no vaccine or therapies available against ZIKV to date. Hence, it is an unmet need to find potential drug candidates and target sites against Zika virus infection. NS2B-NS3 protease making an attractive target for therapeutic intervention in ZIKV infections because of its critical role in hydrolysis of a single polyprotein encoded by Zika virus. Recently, there are some experimental evidence about the flavonoids as Zika virus NS2B-NS3 protease inhibitors. However, molecular interaction between protease complex and inhibitors at atomic levels has not been explored. Here, we have taken the experimentally validated thirty-eight flavonoids inhibitors against NS2B-NS3 protease to examine the molecular interaction using molecular docking and molecular dynamics simulations. We found out few flavonoids such as EGCG and its two derivatives, isoquercetin, rutin and sanggenon O showing interaction with catalytic triad (His51, Asp75, and Ser135) of the active site of NS2B-NS3 protease and found to be stable throughout the simulation. Therefore it is evident that interaction with the catalytic triad playing a vital role in the inhibition of the enzyme activity as a result inhibition of the virus propagation. However these compounds can be explored further for understanding the mechanism of action of these compounds targeting NS2B-NS3 protease for inhibition of Zika virus. Investigating into the Molecular Interactions of Flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches ZIKA virus protease (NS2B-NS3pro) is essential for ZIKA virus replication and maturation. Therefore targeting this protein complex with potential inhibitors will block the viral replication. Here we revealed the interaction of the flavonoids, a successful ZIKA NS2B-NS3pro inhibitors through Molecular modeling and Simulation studies. Communicated by Ramaswamy H. Sarma
Becoming engineers: how students leverage relationships between documents and learning activities
Creators: name: Dodson, Samuel
Publisher: name: University of British Columbia
Year: 2021

description: Learners participate in complex environments that are comprised of diverse and distributed people, information, and tools. To better understand why this situation presents challenges for learners, and to examine how they seek to overcome these challenges, a two-part study was conducted. This research explores undergraduate engineers’ information interactions through a mixed methods study. Questionnaire responses and interviews with students were analyzed to investigate how undergraduate engineers seek, manage, and interact with discipline-specific information and how they share documents with their peers. This work included questionnaire responses from 103 students enrolled in undergraduate engineering programs at a large university in Canada. Follow-up interviews with 18 of these respondents extended accounts of students' experiences. The findings contribute to understandings of how undergraduate engineers navigate complex information environments. Given that students have access to a substantial amount of information communicated in many ways, their ability to select and apply information was found to be integral to their participation in these environments. Results identified and described the latent relationship between learning tasks and document genres. It was also found that students regularly collaborate through social media and other backchannels to sidestep their instructors’ efforts to monitor and control how and what information they share. Findings suggest implications for understanding how students develop awareness about pairing documents with the learning activities in which they are engaged. While students are coping with complex information environments, they are not necessarily using the expected document genres, suggesting areas for adjustments in curriculum, information literacy instruction, and theoretical synthesis.
Light-induced effects in glycine aqueous solution studied by Fourier transform infrared-emission spectroscopy and ultraviolet-visible spectroscopy
Creators: name: Terpugov, Evgeni L.
name: Kondratyev, Maxim S.
name: Degtyareva, Olga V.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Although amino acids are insensitive to visible light, as is generally accepted, we show that particular light-matter interaction can break this obviousness. Using sensitive (FT-IR)-technique in a combination of a broadband visible light source, we registered emission spectra of glycine in the range 2500-500 cm−1. Sensitivity of the infrared emission spectrum to the exciting power –induced changes in the glycine structure was demonstrated experimentally. Vibrational spectra of glycine displayed the prominent spectral features of CH2, COO-, COOH, NH+3 groups in the “fingerprint region”. Simultaneous appearance of ionised COO- and unionised COOH forms of glycine in solution at neutral pH clearly indicated that visible light induces the partial protonation of COO- groups; if so, visible light irradiation should lead to occurrence of dimers or dimeric hydrogen - bonded structures. Spectroscopic and microscopic evidence of visible light-mediated formation of aggregates and nucleus in aqueous solution was presented. Electronic absorption/emission spectra of glycine in aqueous solution were primarily characterized in the near ultraviolet-visible region (240-600 nm). Negligible absorption near 270 nm was observed for a 1.0 M solution and dramatically enhanced with its “aging”. Moreover, an extension of the absorption edge into the region above 400 nm could be seen. Due to the visible light irradiation, we observed modification of electronic structure or occurrence of additional species causing changes in absorption of glycine amino acid. For “aged” solution, it was shown that excitation spectra corresponding to the different emission wavelengths were entirely different, at that each excitation-spectral band had a characteristic emission band. Communicated by Ramaswamy H. Sarma
title: ROR-ing Together in Portugal: A Community Celebration
Creators: name: Gould, Maria
Publisher: name: Research Organization Registry (ROR)
Year: 2020
Subjects: classificationCode: 1.2
subject: FOS: Computer and information sciences

description: ROR had a party in Portugal last month! Sixty friends - some new, some old - came together in Lisbon on the eve of PIDapalooza 2020 to celebrate ROR’s unofficial first birthday, marking one year since the registry debuted at a community meeting in Dublin in January 2019.
Investigation of conformational dynamics of Tyr89Cys mutation in protection of telomeres 1 gene associated with familial melanoma
Creators: name: Mohd. Amir
name: Shahzaib Ahamad
name: Taj Mohammad
name: Deeba Shamim Jairajpuri
name: Hasan, Gulam Mustafa
name: Ravins Dohare
name: Asimul Islam
name: Faizan Ahmad
name: Md. Imtaiyaz Hassan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Protection of telomeres 1 (POT1) is a component of the shelterin complex which is crucial for the regulation of telomere length and maintenance. Many naturally occurring mutations in the POT1 gene have been found to be associated with cardiac angiosarcoma, glioma, familial melanoma, and chronic lymphocytic leukemia. In particular, Y89C is a naturally occurring mutation of POT1, responsible for familial melanoma, and the molecular basis of this mutation is unexplored. In this study, we have extensively analyzed the structure of WT and Y89C mutant of POT1 to see the change in the conformational dynamics, free energy landscape, molecular motions and configurational frustration using molecular dynamics (MD) and other bioinformatics approaches. Y89C mutation shows a significant change in the backbone orientation, compactness, residual fluctuation, solvent accessibility, and hydrogen bonding, suggesting an overall destabilization of the protein structure. Besides, essential dynamics, conformation, magnitude, direction of motion and frustration analysis further suggesting the structural loss in POT1 due to Y89C mutation. Free energy landscape analysis also indicates the presence of a single well-defined free-energy minima in case of WT compared to multiple wells defined free energy minima observed in Y89C, clearly suggesting that this mutation leads to reduce the stability of POT1. This study possibly provides a valuable path to understand the molecular basis of Y89C-mediated development of familial melanoma. Communicated by Ramaswamy H. Sarma
Quando le molle aspettano…
Creators: name: Imparato, Marzia
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2021
Subjects: : didattica della scienza
immagini
immagini dinamiche
video e scienze
smartphone
tecnologia e media
molla slinky

description: Le numerose funzioni e i sensori in dotazione negli smartphone, li rendono degli strumenti dai molteplici impieghi nelle attività di educazione scientifica. La scuola non sfrutta ancora abbastanza il loro potenziale e, nonostante gli sforzi per introdurre sempre di più le nuove tecnologie, sono ancora lasciati negli zaini. Degli smartphone viene sottovalutata soprattutto una delle funzionalità più comuni: la videocamera. Il presente lavoro di diploma raccoglie i risultati ottenuti durante un percorso sperimentale, svolto in una prima media, per verificare le possibilità offerte dalle videocamere come strumento di indagine. Nella classe di applicazione la videocamera è stata usata sia in modalità di ripresa per accelerare la riproduzione di fenomeni naturali lenti, sia per rallentare la visione di un fenomeno fisico altrimenti di difficile interpretazione. I risultati ottenuti hanno permesso di verificare che la produzione e l’elaborazione di filmati generati con le semplici applicazioni di uno smartphone, possono aiutare a comprendere meglio alcuni fenomeni, i cui dettagli sfuggono all’osservazione diretta. Inoltre, l’approccio didattico scelto ha permesso di sviluppare competenze scientifiche mirate, attraverso l’investigazione di due fenomeni di durata opposta che sfuggono alla normale percezione visiva dell’essere umano: il moto apparente del sole e la caduta di una molla. Le indagini svolte hanno contribuito non solo a favorire l’autonomia degli allievi nell’eseguire un’indagine scientifica con il loro smartphone, ma anche a favorire un apprendimento che si alimenta delle tecniche di ripresa, funzionali alla comprensione dei concetti in gioco nei fenomeni oggetto di studio. Relatore: Luca Reggiani.
Multi-epitope based vaccine against Yellow fever virus applying immunoinformatics approaches
Creators: name: Stephane Fraga De Oliveira Tosta
name: Passos, Mariana Santana
name: Kato, Rodrigo
name: Salgado, Álvaro
name: Joilson Xavier
name: Jaiswal, Arun Kumar
name: Siomar C. Soares
name: Azevedo, Vasco
name: Giovanetti, Marta
name: Tiwari, Sandeep
name: Luiz Carlos Junior Alcantara
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Yellow fever disease is considered a re-emerging major health issue which has caused recent outbreaks with a high number of deaths. Tropical countries, mainly African and South American are the most affected by Yellow fever outbreaks. Despite the availability of an attenuated vaccine, its use is limited for some groups such as pregnant and nursing women, immunocompromised and immunosuppressed patients, elderly people >65 years, infants <6 months and patients with biological disorders like thymus disorders. In order to achieve new preventive measures, we applied immunoinformatics approaches to develop a multi-epitope based subunit vaccine for Yellow fever virus. Different epitopes, related to humoral and cell-mediated immunity, were predicted for complete polyproteins of two Yellow fever strains (Asibi and 17D vaccine). Those epitopes common for both strains were mapped into a set of 137 sequences of Yellow fever virus, including 77 sequences from a recent outbreak at the state of Minas Gerais, southeast Brazil. Therefore, the present work uses robust bioinformatics approaches for the identification of a multi-epitope vaccine against the Yellow fever virus. Our results indicate that the identified multi-epitope vaccine might stimulate humoral and cellular immune responses and could be a potential vaccine candidate against Yellow fever virus infection. Hence, it should be subjected to further experimental validations.
title: Sozial verantwortliches Reisen durch Gamification - Konzipierung einer mobilen App zur Bewusstseins- und Motivationssteigerung für soziokulturelle und sozioökonomische Nachhaltigkeit im Urlaub
title: Socially responsible Travel by Gamification Conception of a mobile App to increase Awareness and Motivation for socio-cultural and socio-economic Sustainability on Vacation
titleType: AlternativeTitle
Creators: name: Kommnick, Birte
Publisher: name: Hochschule Bremen
Year: 2022
Subjects: subject: Soziale Nachhaltigkeit
subject: Tourismus
subject: Gamification
subject: 300

description: Die vorliegende Masterarbeit beschäftigt sich mit der Konzipierung einer mobilen App für sozial nachhaltigen Tourismus. Da vergleichbare Apps in diesem Bereich zurzeit noch nicht existieren, handelt es sich dabei um eine explorative Forschungsarbeit. Ausgangspunkt stellen dabei die vielfältigen sozialen Auswirkungen des Tourismus sowie die aus der Umweltforschung bekannte Attitude-Behaviour-Gap dar. Die geplante App soll an dieser Problemstellung ansetzen und die Reisenden auf spielerische Art und Weise dabei unterstützen, ihr Reiseverhalten in eine sozioökonomisch und soziokulturell nachhaltige Richtung anzupassen. Die Entwicklung des Konzepts erfolgt mittels Literaturrecherche relevanter Themen wie Verhaltenstheorien, Interventionsformen sowie Gamification-Modellen. Andererseits wird eine Fokusgruppendiskussion mit anschließender qualitativer Inhaltsanalyse durchgeführt, um auch die Wünsche potentieller Nutzer*innen zu berücksichtigen. Der Fokus der App-Entwicklung soll liegt darin, Möglichkeiten und Funktionen zu finden, durch die ein Problembewusstsein geschaffen und eine Verhaltensänderung bewirkt wird. Auf der anderen Seite soll die Nutzung der App aber auch einen Mehrwert für die Anwender*innen schaffen und als zusätzliches Reiseerlebnis wahrgenommen werden.
A-CaMP: a tool for anti-cancer and antimicrobial peptide generation
Creators: name: Kaushik, Aman Chandra
name: Mehmood, Aamir
name: Shaoliang Peng
name: Zhang, Yu-Juan
name: Xiaofeng Dai
name: Wei, Dong-Qing
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Anti-cancer peptides (ACPs) play a vital role in the cell signaling process. Antimicrobial peptides (AMPs) provide immunity against pathogenic microbes, AMPs present activity against pathogenic microbes. Some of them are known to possess both anticancer and antimicrobial activity. However, so far, no tools have been developed that could predict potential ACPs from wild and mutated cancerous protein sequences in the numerous public databases. In the present study, we developed a A-CaMP tool that allows rapid fingerprinting of the anti-cancer and antimicrobial peptides, which play a crucial role in current bioinformatics research. Besides, we compared the performance and functionality of our A-CaMP tool with those of other methods available online. A-CaMP scans the target protein sequences provided by the user against the datasets. It possesses a robust coding architecture, has been developed in PERL language and is scalable of therefore has extensive applications in bioinformatics. It was observed to achieve a prediction accuracy of 93.4%, which is much higher than that of any of the existing tools. Sequence alignment studies also highlight the potential use of A-CaMP as a tool for the identification of AMPs. A-CaMP is the first open source tool that uses clinical data and proposes final peptides along with the necessary information; this includes wild and mutant sequence and peptides, which lays the foundation for its application in therapies for cancer and bacterial infections. Communicated by Ramaswamy H. Sarma.
Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach
Creators: name: D Thirumal Kumar
name: Jain, Nikita
name: Udhaya Kumar S
name: C GeorgePriya Doss
name: Zayed, Hatem
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into mannose-1-phosphate. Here, a computational pipeline was drawn to identify the most significant mutations, and further, we used a virtual screening approach to identify a new lead compound to treat the identified significant mutations. We searched for missense mutation data related to PMM2-CDG in HGMD®, UniProt, and ClinVar. Our search yielded a total of 103 mutations, of which 91 are missense mutations. The D65Y, I132N, I132T, and F183S mutations were classified as deleterious, destabilizing, and altering the biophysical properties using the PredictSNP, iStable, and Align GVGD in silico prediction tools. Additionally, we applied a multistep protocol to screen for an alternative lead compound to the existing CID2876053 (1-(3-chlorophenyl)-3,3-bis(pyridine-2-yl)urea) with affinity to these identified significant mutants. Two compounds, CHEMBL1491007 (6-chloro-4-phenyl-3-(4-pyridin-2-ylpiperazin-1-yl)-1H-quinolin-2-one) and CHEMBL3653029 (5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]-N-(piperidin-4-ylmethyl)pyridin-2-amine), exhibited the highest binding affinity with the selected mutants and were chosen for further analysis. Through molecular docking, molecular dynamics simulation, and MMPBSA analysis, we found that the known compound, i.e., CID2876053, has stronger interaction with the D65Y mutant. The newly identified lead compound CHEMBL1491007 showed stronger interaction with the I132N and I132T mutants, whereas the most deleterious mutant, F183S, showed stronger interaction with CHEMBL3653029. This study is expected to aid in the field of precision medicine, and further to in vivo and in vitro analysis of these lead compounds might shed light on the treatment of PMM2-CDG.
title: In vitro ÑÐµÑÑ-ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð»Ñ Ð¾ÑÐµÐ½ÐºÐ¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ°ÑÐ¼Ð°ÐºÐ¾ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð½Ð° ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑÑÑ ÑÐºÐ°Ð½ÐµÐ¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹ ÑÐ¾Ð³Ð¾Ð²Ð¸ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: In vitro test-systems for the assess of the effect of pharmacotherapy on the cellular component of corneal tissue-engineered structures
Creators: name: ÐÐµÑÐµÐ¿Ð»ÐµÑÑÐ¸ÐºÐ¾Ð²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐµ ÐºÑÐ»ÑÑÑÑÑ
ÑÐ¸ÑÐ¾ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÑ
Ð¾ÑÑÐ°Ð»ÑÐ¼Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð»Ð¸Ð¼Ð±Ð°Ð»ÑÐ½ÑÐµ ÑÑÐ²Ð¾Ð»Ð¾Ð²ÑÐµ ÐºÐ»ÐµÑÐºÐ¸
ÑÐ¾Ð³Ð¾Ð²Ð¸ÑÐ°
cell culture
cytotoxicity
ophthalmology
limbal stem cells
the cornea

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·ÑÑÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐ° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾Ð³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ°ÑÐ¼Ð°ÐºÐ¾ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð½Ð° ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¹ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½Ñ ÑÐºÐ°Ð½ÐµÐ¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹ Ð´Ð»Ñ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ¿Ð¸ÑÐµÐ»Ð¸Ñ ÑÐ¾Ð³Ð¾Ð²Ð¸ÑÑ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ in vitro Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ ÑÐµÑÑ-ÑÐ¸ÑÑÐµÐ¼. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð² Ð±ÑÐ»Ð¾ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ Ð¿ÑÐ¾ÑÐ²Ð»ÑÑÑ ÑÐ²Ð¾Ñ ÑÐ¸ÑÐ¾ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÑ ÑÐ¶Ðµ Ð² Ð¿ÐµÑÐ²ÑÐµ ÑÐ°ÑÑ Ð¿Ð¾ÑÐ»Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ, Ð° Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° ÐºÐ»ÐµÑÐºÐ¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð³Ð»Ð°Ð·Ð° Ð²Ð½ÑÑÑÐ¸ ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð³ÑÑÐ¿Ð¿ ÑÐ°Ð·Ð»Ð¸ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÑ ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÐ¸. ÐÐ°Ð½Ð½ÑÐµ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð² ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ ÐºÐ¾ÑÐ²ÐµÐ½Ð½Ð¾ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ, ÑÑÐ¾ Ð½ÐµÐ¿ÑÐ°Ð²Ð¸Ð»ÑÐ½Ð¾ Ð¿Ð¾Ð´Ð¾Ð±ÑÐ°Ð½Ð½ÑÐ¹ Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ Ð¼Ð¾Ð¶ÐµÑ Ð¿ÑÐ¸Ð²ÐµÑÑÐ¸ Ðº Ð³Ð¸Ð±ÐµÐ»Ð¸ ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº Ð¸ Ð·Ð°Ð¼ÐµÑÐ½Ð¾ ÑÐ½Ð¸Ð·Ð¸ÑÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð².
description: In this work the assessment of the possible effect of pharmacotherapy on the cellular component of tissue-engineered structures for the restoration of the corneal epithelium in vitro was studied by using cellular test systems. Based on the experiments, it was found that the drugs exhibit their cytotoxicity in the first hours after application, and their effect on the cells of the eye tissues within the pharmacological groups varies in the level and nature of toxicity. The data obtained during the work allow to indirectly predict that the wrong drug can lead to the death of transplanted cells and significantly reduce the effectiveness of reparative processes.
Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum
Creators: name: Singh, Rahul
name: Bhardwaj, Vijay
name: Rituraj Purohit
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The deadliest disease caused by the Plasmodium species is malaria. Among other species, the infection caused by Plasmodium falciparum (Pf) is life-threatening.The biological function and three dimensional structure of PfLDH and human LDH are very similar. Any treatment aiming to inhibit the PfLDH can also affect the activity of human LDH. This study aims to identify molecules that show high selectivity for PfLDH without having a profound effect on the activity of human LDH. In this study, 30 in-house synthesized Quinolines based molecules were docked with both PfLDH and human LDH. Based on molecular docking results, molecules 3j, 4b, 4h, 4m were showed selectivity towards PfLDH. All the four molecules had better binding affinity, ligand efficiency, lipophilic ligand efficiency, and torsion than Chloroquine (referenced inhibitor). Further, molecular dynamics (MD) simulations and molecular mechanics poisson boltzmann surface area (MM-PBSA) calculations were carried out to validate the docking results and to compare the stability of selected complexes against the complex with Chloroquine. MD simulations showed stable dynamic behavior of all the selected molecules in comaprison to Chloroquine. Finally, on the basis of MM-PBSA analysis, molecule 3j was revealed novel binding mechanism and was selected as the potent and selective inhibitor of PfLDH.
Is a good bot better than a mediocre human? : chatbots as alternatives sources of social connection
Creators: name: Folk, Dunigan
Publisher: name: University of British Columbia
Year: 2021

description: Around the world, hundreds of millions of people have used social chatbots designed to provide companionship to their users. But can people reap genuine feelings of social connection and happiness from interacting with chatbots? Across four pre-registered studies (N = 1201), participants shared good news with an interaction partner whom they believed was either a chatbot or a human. The conversation partner responded in either a highly responsive or less responsive manner. Across the studies, interacting with a highly responsive chatbot was more rewarding than interacting with a less responsive human. Participants who believed they interacted with a highly responsive chatbot felt more rapport, were more socially connected, and were in a better mood than participants who interacted with a less responsive human. Despite their inherent lack of agency, chatbots that are programmed to respond in an optimal manner may deliver greater social benefits than suboptimal human conversation partners.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ Ð¿Ð¾ÑÑÐ¸ÑÐ¸Ð½Ð¾Ð²ÑÑ Ð¿Ð»ÐµÐ½Ð¾Ðº Ð² ÑÐ¸Ð»ÑÐ½ÑÑ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Study of the conductivity of porphyrin films in strong electric fields
Creators: name: ÐÑÑÑÐ½ÑÐ¾Ð³ÑÐ¾Ñ, ÐÐ¾Ð»Ð¾ÑÐ¼Ð°Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¿Ð¾ÑÑÐ¸ÑÐ¸Ð½Ñ
ÑÐ¾Ð½ÐºÐ¸Ðµ Ð¿Ð»ÐµÐ½ÐºÐ¸
ÐÐÐ¥
Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÑ
ÑÐ¾Ðº
Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð½ÑÐ¹ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½ÑÐ¼ Ð·Ð°ÑÑÐ´Ð¾Ð¼
Ð»Ð¾Ð²ÑÑÐºÐ¸
porphyrin
thin films
ZnTPP
CuTPP
FeCLTPP
I-V characteristics
conductivity
current limited by a space charge
traps

description: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ ÑÑÑÑÐºÑÑÑÐ° Ð¸ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÑ ÑÐ¾Ð½ÐºÐ¸Ñ Ð¿Ð»ÐµÐ½Ð¾Ðº Ð¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»ÑÐ¿ÑÐ¾Ð²Ð¾Ð´Ð½Ð¸ÐºÐ¾Ð²: Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿Ð¾ÑÑÐ¸ÑÐ¸Ð½Ð¾Ð²ÑÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð² MeTPP(Me=Zn, Cu, FeCl), Ð¸ Ð¸Ñ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¾Ð² Ñ ÑÑÐ»Ð»ÐµÑÐµÐ½Ð¾Ð¼ C60, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð²Ð°ÐºÑÑÐ¼Ð½Ð¾Ð³Ð¾ Ð½Ð°Ð¿ÑÐ»ÐµÐ½Ð¸Ñ Ð² ÐºÐ²Ð°Ð·Ð¸ÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ. ÐÐ·ÑÑÐµÐ½Ñ Ð²Ð¾Ð»ÑÑ-Ð°Ð¼Ð¿ÐµÑÐ½ÑÐµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ Ð² ÑÐ¸Ð»ÑÐ½ÑÑ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»ÑÑ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð½Ð¾ÑÑÑÑ Ð´Ð¾ 105-106 Ð/ÑÐ¼. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÐÐÐ¥ ÑÑÑÑÐºÑÑÑ Ð¸Ð¼ÐµÐµÑ ÑÐ¸Ð»ÑÐ½Ð¾ Ð½ÐµÐ»Ð¸Ð½ÐµÐ¹Ð½ÑÐ¹ ÑÐ°ÑÐ°ÐºÑÐµÑ Ð¸ Ð·Ð°Ð²Ð¸ÑÐ¸Ñ Ð¾Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ° ÑÐ¾ÑÐ¼Ð¾Ð²ÐºÐ¸ Ð² ÑÐ¸Ð»ÑÐ½Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¼ Ð¿Ð¾Ð»Ðµ. ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð° Ð¼Ð¾Ð´ÐµÐ»Ñ, Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÑÑÐ°Ñ ÐÐÐ¥ ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¿Ð»ÐµÐ½Ð¾Ðº Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð¼ ÑÐ¾ÐºÐ°, Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½ÑÐ¼ Ð·Ð°ÑÑÐ´Ð¾Ð¼ Ñ Ð³Ð°ÑÑÑÐ¾Ð²ÑÐ¼ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸ÐµÐ¼ Ð»Ð¾Ð²ÑÑÐµÐº. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¿Ð¾Ð´Ð²Ð¸Ð¶Ð½Ð¾ÑÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹, ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ Ð¸ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ Ð»Ð¾Ð²ÑÑÐµÐº Ð´Ð»Ñ MeTPP (Me=Zn, Cu). ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð½Ð°Ð»Ð¸ÑÐ¸Ðµ ÑÑÑÐµÐºÑÐ° ÑÐµÐ·Ð¸ÑÑÐ¾Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÐµÑÐµÐºÐ»ÑÑÐµÐ½Ð¸Ñ.
description: The structure and conductivity of thin films of organic semiconductors: metal porphyrin complexes MeTPP (Me = Zn, Cu, FeCl), obtained by vacuum deposition under quasi-equilibrium conditions were investigated. Voltage-current characteristics in strong electrical filds up to 105-106 V/cm are studied. It is shown that the current â voltage characteristics of the structures are highly nonlinear and depend on the molding process in a strong electric field. A model is proposed that describes the current-voltage characteristics of the formed films by the mechanism of a current limited by a space charge with a Gaussian distribution of traps.
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð´Ð»Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ ÑÐ°ÑÑÐµÐ¸Ð²Ð°ÑÐµÐ»ÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of a programme to simulate the interaction of electromagnetic scatterers
Creators: name: Ð¨Ð°Ð»Ð³ÑÐµÐ²Ð°, Ð¡Ð¾ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸
Ð´Ð¸Ð¿Ð¾Ð»Ð¸
ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÐµ ÑÐ°ÑÑÐµÐ¸Ð²Ð°ÑÐµÐ»Ð¸
ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¹
ddassl
ddaspk
mathematical models
dipoles
electromagnetic scatterers
numerical methods of differential equations solution

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ ÑÐ°ÑÑÐµÐ¸Ð²Ð°ÑÐµÐ»ÐµÐ¹ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¼Ð¾Ð½Ð¾ÑÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð½Ð°ÐºÐ°ÑÐºÐ¸. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¸Ð²Ð¾Ð´ÑÑÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Ð´Ð»Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÑ ÑÐ°ÑÑÐµÐ¸Ð²Ð°ÑÐµÐ»ÐµÐ¹, ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Ð¸ Ð²ÑÐ²Ð¾Ð´Ñ Ð¾ ÑÐµÐ»ÐµÑÐ¾Ð¾Ð±ÑÐ°Ð·Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð². Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÐµÐ½Ð° Ð½Ð° ÑÐ·ÑÐºÐµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Fortran, Ð²ÑÐ¾Ð´ÑÑÐµÐ³Ð¾ Ð² ÑÐ¾ÑÑÐ°Ð² MinGW gfortran, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¸Ð½ÑÐµÐ³ÑÐ¸ÑÑÐµÑÑÑ Ñ Code::Blocks.
description: This work is devoted to modeling of interaction of electro-magnetic scatterers under monochromatic pumping. The paper presents results of simulation of interaction of electromagnetic scatterers, comparison of results with available simulation software and concluding the reasonability of various approaches. The software is developed in the Fortran programming language, a part of MinGW gfortran, which is integrated with Code::Blocks.
title: Ð¡Ð²ÑÐ·Ñ ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸Ñ Ñ Ð¿ÑÐ¸Ñ Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÑÑÑÐµÑÐ¾Ð¼ Ð»Ð¸ÑÐ½Ð¾ÑÑÐ¸ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÐºÐ¾Ð² ÐÑÑÑÐµÐ¹ ÑÐºÐ¾Ð»Ñ ÑÐµÑ Ð½Ð¾ÑÑÐµÑÐ½Ð¾Ð¹ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The relationship of fatigue with the psychological portrait of the individual on the example of employees of the Higher school of technosphere security
Creators: name: ÐÐ¾Ð³Ð°ÑÐµÐ²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÑÑÐ´Ð¾Ð²Ð°Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ
ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸Ðµ
Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸Ñ
Ð¿ÑÐ¸Ñ Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¿Ð¾ÑÑÑÐµÑ Ð»Ð¸ÑÐ½Ð¾ÑÑÐ¸
Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¸Ñ Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÑÑÐµÑÐ° Ð»Ð¸ÑÐ½Ð¾ÑÑÐ¸
labour activity
fatigue
method for identifying fatigue
psychological profile
method for complation of psychological profile

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ñ ÑÑÑÐ´Ð¾Ð²Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÐºÐ¾Ð² ÐÐ¨Ð¢Ð, Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð¿Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÑÑÐµÑÐ° Ð»Ð¸ÑÐ½Ð¾ÑÑÐ¸. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð° Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° ÑÐ»Ð°Ð±Ð°Ñ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¼ÐµÐ¶Ð´Ñ ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸ÐµÐ¼ Ð¸ Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÑÑÑÐµÑÐ¾Ð¼ Ð»Ð¸ÑÐ½Ð¾ÑÑÐ¸. ÐÐ¾ÑÐºÐ¾Ð»ÑÐºÑ Ñ Ð±Ð¾Ð»ÑÑÐ¸Ð½ÑÑÐ²Ð° ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÐºÐ¾Ð² ÐÐ¨Ð¢Ð Ð±ÑÐ»Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¸ ÑÑÐ¾Ð¼Ð»ÐµÐ½Ð¸Ñ, ÑÐ¾ Ð±ÑÐ»Ð° Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð° Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ¸ ÑÑÐ¾Ð¼Ð»ÑÐµÐ¼Ð¾ÑÑÐ¸ Ð½Ð° ÑÐ°Ð±Ð¾ÑÐµÐ¼ Ð¼ÐµÑÑÐµ Ð´Ð»Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð² ÑÐ¼ÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸.
description: In this paper, we consider the basics of working activity of HSTS employees, methods for diagnosing fatigue, as well as methods for drawing up a psychological portrait of a person. Based on the results of this work, a weak correlation was determined between the mood and the psychological portrait of the individual. Since most of the employees of the HSTS showed signs of fatigue, a program for preventing fatigue in the workplace for mental workers was proposed.
Small angle X-ray scattering based structure, modeling and molecular dynamics analyses of family 43 glycoside hydrolase α-L-arabinofuranosidase from Clostridium thermocellum
Creators: name: Kedar Sharma
name: Fontes, Carlos M.G.A.
name: Najmudin, Shabir
name: Goyal, Arun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry

description: Enzymes that participate in the hydrolysis of complex carbohydrates display a modular architecture, although the significance of enzyme modularity to flexibility and catalytic efficacy is not fully understood. α-L-arabinofuranosidase from Clostridium thermocellum (CtAraf43) catalyzes the release of α-1,2-, α-1,3-, or α-1,5- linked L-arabinose from arabinose decorated polysaccharides. CtAraf43 comprises an N-terminal catalytic domain (CtAbf43A) connected with two family 6 carbohydrate-binding modules (CBMs), termed as CtCBM6A and CtCBM6B, through flexible linker peptides. Here, we modeled the structure of CtAraf43 revealing that the module, CtAbf43A displays a 5-fold β-propeller fold and the CBMs the typical jellyroll type β-sandwich folds. Ramachandran plot showed 98.5% residues in the favored region and 1.5% residues in the disallowed region. Molecular dynamics simulation analysis of CtAraf43 revealed significant flexibility that is more expressive in the C-terminal CtCBM6B module in terms of structure and orientation. Small angle X-ray scattering analysis of CtAraf43 revealed its elongated structure. CtAraf43 at 1.2 mg/mL demonstrated the monomeric nature and a multi-modular shaped molecular envelope in solution with a Dmax of 12 nm. However, at 4.7 mg/mL, CtAraf43 displayed a dimeric structure and elongated molecular envelope. Kratky plot analysis revealed the folded state of CtAraf43 with limited flexibility at both concentrations. The data revealed higher flexibility at the C-terminal of CtAraf43 suggesting a coordinated action of the N-terminal catalytic module CtAbf43A and the internal CtCBM6A.
The complete chloroplast genome of Abies ernestii Rehder (Pinaceae) and its phylogenetic implications
Creators: name: Shao, Yi-Zhen
name: Shi, Zhi-Yuan
name: Wang, Zhao
name: Wang, Wei
name: Chen, Yun
name: Wen, Qian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Abies ernestii Rehder is endemic to the montane regions of Southwest China. Till now, phylogenetic relationships between A. ernestii and other closely related species remain unclear. In this study, we first characterized the complete chloroplast (cp) genome of A. ernestii. The whole cp genome was 121,841 bp in size, including one hundred and thirteen genes. Results of comparative cp genome revealed that only ycf1 and ycf2 was characterized by a considerable variation. Our phylogenetic analyses supported the monophyly of the genus Abies and revealed a clear separation between A. ernestii and A. chensiensis Tiegh. This study highlights the significance of using cp genomes to examine species boundaries among closely related fir species.
title: ÐÐ°ÑÐ¾ÑÐ½Ð°Ñ ÑÑÐ°Ð½ÑÐ¸Ñ Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ Ð¿Ð¾Ð´ÑÐµÐ¼Ð° Ð² Ð³Ð¾ÑÐ¾Ð´Ðµ ÐÑÑÐ·Ð¸ (ÐÐ¸Ð¿ÐµÑÐºÐ°Ñ Ð¾Ð±Ð»Ð°ÑÑÑ): Ð°Ð»ÑÑÐµÑÐ½Ð°ÑÐ¸Ð²Ð½ÑÐ¹ Ð²Ð°ÑÐ¸Ð°Ð½Ñ ÑÐµÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: A first stage pumping house in Griazi (Lipetsk region): an alternative reconstruction
Creators: name: ÐÐ°Ð²ÑÑÑÐ¸Ð½Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð½Ð°ÑÐ¾ÑÐ½Ð°Ñ ÑÑÐ°Ð½ÑÐ¸Ñ
Ð½Ð°ÑÐ¾Ñ
Ð¿Ð¾Ð´Ð°ÑÐ°
Ð½Ð°Ð¿Ð¾Ñ
Ð²Ð¾Ð´Ð¾Ð·Ð°Ð±Ð¾ÑÐ½Ð°Ñ ÑÐºÐ²Ð°Ð¶Ð¸Ð½Ð°
ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ½Ð°Ñ Ð¿Ð»Ð¸ÑÐ°
ÑÐµÐ¿Ð»Ð¾ÑÐµÑ Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°ÑÑÐµÑ
pumping station
pump
pump rate
pump head
water-intake well
base slab
thermotechnical calculation

description: Ð Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐ¾ÐµÐºÑ ÑÐµÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð·Ð´Ð°Ð½Ð¸Ð¹ ÑÐµÑÑÑÐµÑ Ð½Ð°ÑÐ¾ÑÐ½ÑÑ ÑÑÐ°Ð½ÑÐ¸Ð¹ I-Ð³Ð¾ Ð¿Ð¾Ð´ÑÐµÐ¼Ð° Ð½Ð°Ð´ Ð²Ð¾Ð´Ð¾Ð·Ð°Ð±Ð¾ÑÐ½ÑÐ¼Ð¸ ÑÐºÐ²Ð°Ð¶Ð¸Ð½Ð°Ð¼Ð¸ Ð² Ð³. ÐÑÑÐ·Ð¸ ÐÐ¸Ð¿ÐµÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸.
ÐÐ°Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÑÑÐ¸Ðµ Ð½Ð°Ð·ÐµÐ¼Ð½ÑÐµ Ð¿Ð¾Ð¼ÐµÑÐµÐ½Ð¸Ñ Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐ¼Ð¸ Ð½Ð°ÑÐ¾ÑÐ°Ð¼Ð¸ Ð¸ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð´Ð»Ñ Ð¸Ñ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ. Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ ÑÐµÐ¿Ð»Ð¾Ð¿Ð¾ÑÐµÑÐ¸ Ð·Ð´Ð°Ð½Ð¸Ð¹ Ð¸ Ð¿ÑÐ¸Ð±Ð»Ð¸Ð·Ð¸ÑÐµÐ»ÑÐ½Ð°Ñ ÑÑÐ¾Ð¸Ð¼Ð¾ÑÑÑ Ð½Ð°ÑÐ¾ÑÐ½ÑÑ ÑÑÐ°Ð½ÑÐ¸Ð¹, Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ½ÑÑ Ð¿Ð»Ð¸Ñ.
description: A renovation project of four first stage pumping station houses above water-intake wells in Griazi (Lipetsk region) was developed in the graduate qualification work. Dry above-grade buildings with modern pumps and maintenance equipment are designed. During the engineering process heat losses and approximate charges of pumping station houses were counted. Calculation of base slams was carried out.
Operation OPSON IV
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Tübingen
Year: 2015
Subjects: subject: Fälschung , Lebensmittel , Organisiertes Verbrechen
subject: 360

description: Report from May 2015 on Operation OPSON IV targeting fake and substandard food and drink, as well as the organized crime networks behind this illicit trade.
EU Terrorism Situation and Trend Report
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Tübingen
Year: 2007
Subjects: subject: Terrorismus , Europäische Union
subject: 360

description: The EU Terrorism Situation and Trend Report (TE-SAT) was established as a reporting mechanism from the Terrorism Working Party (TWP) to the European Parliament in the aftermath of the 9/11 attacks in 2001. Four editions of the TE-SAT have been presented to date by the Presidencies “based on a file and on the analyses supplied by Europol” from Member States’ contributions. 1 In the beginning of 2006, Europol proposed to widen the data collection for the TE-SAT in order to enhance the quality of the report. The proposal was endorsed by the Justice and Home Affairs Council on 1 and 2 June 2006. This TE-SAT follows the new methodology developed by Europol in consultation with the Finnish and German Presidencies, Eurojust and SITCEN. According to ENFOPOL 65 (8196/2/06), the TE-SAT is an unclassified annual document which provides information on the phenomenon of terrorism in the EU. The phenomenon of terrorism is discussed in the TE-SAT 2007 from the law enforcement point of view as a ‘crime’ although, admittedly, terrorism is fundamentally a political phenomenon driven by political motives and oriented toward political ends. As an analytical report, the TE-SAT is a situation report. It describes the outward manifestations of terrorism i.e. terrorist attacks and activities. It neither attempts to analyse the root causes of terrorism nor to assess the threat posed by terrorism. Furthermore, the TE-SAT does not assess the impact or effectiveness of counter-terrorism policies and law enforcement measures taken, despite the fact that they form an important part of the phenomenon. The TE-SAT 2007 is an EU report and as such aims at providing an overview of the situation in the EU instead of describing the situation in single Member States as was the case in earlier editions of the TE-SAT. It seeks to establish basic facts and figures regarding terrorist attacks and activities in the EU. The TE-SAT is,however, also a trend report. Since a trend can be defined as “a general tendency in the way a situation is changing or developing”, the TE-SAT is a forward-looking report, which is why the first issue of the Europol TE-SAT is called TE-SAT 2007. However, due to changes in the methodology, it is difficult to compare the findings of the TE-SAT 2007 to earlier editions of the TE-SAT and establish trends. The TE-SAT is based mainly on information contributed by the Member States concerning and resulting from criminal investigations into terrorism offences. The TE-SAT does not contain information which is classified or which could jeopardise ongoing investigations.
Structural heterogeneity in RNA recognition motif 2 (RRM2) of TAR DNA-binding protein 43 (TDP-43): Clue to amyotrophic lateral sclerosis.
Creators: name: Amresh Prakash
name: Kumar, Vijay
name: Atanu Banerjee
name: Lynn, Andrew M.
name: Prasad, Rajendra
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience

description: Aberrant misfolding and aggregation of TAR DNA-binding protein 43 (TDP-43) and its fragments have been implicated in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Within the protein, the second RNA recognition motif (RRM2) has recently been demonstrated to be a major contributor towards aggregation and the resultant toxicity. However, the physicochemical mechanism of its misfolding from the functional folded state is poorly understood.
Additional file 1 of Factors influencing procurement behaviour and decision-making: an exploratory qualitative study in a UK healthcare provider
Creators: name: Boulding, Harriet
name: Hinrichs-Krapels, Saba
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.
EU Terrorism Situation and Trend Report
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Tübingen
Year: 2008
Subjects: subject: Terrorismus , Europäische Union
subject: 360

description: The EU Terrorism Situation and Trend Report (TESAT) was established in the aftermath of the 11 September 2001 attacks in the United States as a reporting mechanism from the EU Council’s Terrorism Working Party (TWP) to the European Parliament. The first five editions of the TE-SAT were presented by the respective Presidencies of the EU Council, “based on a file and on the analyses supplied by Europol” from member states’ contributions.1 At the beginning of 2006, Europol proposed to widen the data collection for the TE-SAT in order to enhance the quality of the report. The proposal was endorsed by the Justice and Home Affairs Council on 1 and 2 June 2006, and TE-SAT 2007 was based on a new methodology developed by Europol in consultation with the advisory board of 2006, consisting of the Finnish and German Presidencies, Eurojust and SitCen (the EU Joint Situation Centre).2 For TE-SAT 2008, the scope of the report has been slightly modified regarding the qualitative data, allowing the member states to report on criminal acts committed by extremists. This change has been made in consultation with the advisory board of TE-SAT 2008, consisting of the Portuguese and Slovenian Presidencies, Eurojust and SitCen. In accordance with ENFOPOL 65 (8196/2/06), the TE-SAT is an unclassified annual document which provides information on the phenomenon of terrorism in the EU. The TE-SAT discusses terrorism from a law enforcement point of view, i.e. as a “crime”, although terrorism is fundamentally a political phenomenon driven by political motives and oriented toward political ends. The TE-SAT is a situation report which describes and analyses the outward manifestations of terrorism, i.e. terrorist attacks and activities. It neither attempts to analyse the root causes of terrorism nor to assess the threat posed by terrorism. Furthermore, the TE-SAT does not assess the impact or effectiveness of counter-terrorism policies and law enforcement measures taken, despite the fact that they form an important part of the phenomenon. The TE-SAT is an EU report and, as such, aims at providing an overview of the situation in the EU rather that describing the situation in individual member states. It seeks to establish basic facts and figures regarding terrorist attacks, arrests and activities in the EU. The TE-SAT is also a trend report. Since a trend can be defined as a general tendency in the way a situation is changing or developing, the TE-SAT is a forward-looking report. As TE-SAT 2007 was the first report based on the new methodology, no comparison with previous years was possible. Consequently, TE-SAT 2008 is the first edition that attempts an analysis of trends. The TE-SAT is based mainly on information contributed by the member states concerning and resulting from criminal investigations into terrorist offences. The TE-SAT does not contain information which is classified or which could jeopardise ongoing investigations.