cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring Out-of-Sample Prediction and Spatial Dependency for Complex Big Data
Creators: name: Bilchouris, Adam
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4605
subject: Data management and data science
classificationCode: 490511
subject: Time series and spatial modelling

description: A thesis submitted in total fulfilment of the requirements for the degree of Master of Science to the School of Computing, Engineering and Mathematical Sciences, La Trobe University, Victoria, Australia.
Chicago Council on Foreign Relations Poll: July 2004
Creators: name: Chicago Council On Global Affairs
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Interest in United States foreign relations (1); federal government programs (9); threats to the United States (13); United States foreign policy goals (14); United States treaty participation (5); international economic organizations (2); United Nations World Court (1); torturing prisoners (1); United Nations Security Council (6); use of United States troops (15); United States world policeman (2); nuclear weapons use (1); measures to combat terrorism (11); United States government overthrowing other governments (2); conditions for countries to have the right to go to war (6); North Korea nuclear weapons (11); influence on United States foreign policy (13); Middle East military presence (1); NATO (1); United Nations United States relations (2); United Nations powers (3); role in creating new Iraqi constitution (1); World Health Organization authority (1); engage in trade with countries (5); international trade (30); globalization (2); farming subsidies (4); foreign aid (6); long-term military bases (11); terrorism (2); United States superpower (3); United States Middle East relations (5); Mexico United States relations (8); legal immigration (1); North American Free Trade Agreement (10); adults in Mexico native language (1); marijuana (2); Mexican immigrants to the United States (4); temporary worker status (1); feelings toward countries and peoples (11); feelings toward international organizations (9); diplomatic relations (4); traveled to Mexico (1); European Union currency (1); Secretary General of the United Nations (1).
title: Reservoir characterization of the coal-bearing Upper Carboniferous clastic succession, Ruhr area, Germany
Creators: name:  Greve ,   Jonas
name:  Busch ,   Benjamin
name:  Quandt ,   Dennis
name:  Hilgers ,   Christoph
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Structural Geology & Tectonics, Karlsruhe Institute of Technology(2);Due to the closure of coal mining in the northwestern German coalfields, active mine water drainage becomes technically redundant. As a result, the rising mine water table affects the subsurface stress conditions and may induce heterogeneous ground movements of fault blocks. Petrophysical properties of the Upper Carboniferous (Westphalian A and B) rocks are crucial to understand subsurface behavior during mine water rise. As a part of the interdisciplinary FloodRisk project, we present a petrophysical and petrographical characterization of Westphalian A and B drill cores from the Ruhr area. Based on fining-upward cycles consisting of basal sandstones (medium-grained, planar laminated) followed by siltstones with intercalated lower (planar/wavy laminated to bioturbated/rooted) mudstones and coal seams at the top, that are locally overlain by clayey deposits, the rock succession was interpreted as fluvio-deltaic facies association. Petrophysical measurements on core plugs indicate that most samples are generally tight (mean permeability: 0.26 mD; mean porosity: 6.4 %) but reservoir properties vary by grain size and facies. Petrographic analyses indicate that sandstone cementation is dominated by ferroan carbonate (mostly siderite and Fe-calcite) and quartz overgrowth in the pore space. Locally, veins are cemented by ferroan calcite or sulfides. Feldspar-rich rock fragments are often replaced by kaolinite, reducing the secondary porosity. The outcome of this investigation will be integrated into an interdisciplinary model that involves geomechanical, geodetic and geophysical data in order to understand subsurface flow. Furthermore, data can be used to consider the fluid distribution for potential geothermal energy use.
Kontaktverweigerung des Kindes: Sozialarbeitende im Gespräch mit dem 4- bis 12-jährigen Kind im Rahmen einer Beistandschaft nach Art. 308 Abs. 2 ZGB
Creators: name: Hollander, Christa
Publisher: name: Zenodo
Year: 2020

description: Die vorliegende Bachelor-Arbeit richtet den Fokus auf das von einer Beistandschaft nach Art. 308 Abs. 2 ZGB betroffene Kind. Liegt ein hochstrittiger Elternkonflikt um das Kind vor, kann dies aufgrund hoher emotionaler Belastungen eine Kontaktverweigerung des Kindes gegenüber dem besuchsberechtigten Elternteil zur Folge haben. Negative psychische und physische Folgen für das Kind sind wahrscheinlich. Im Hinblick auf das Kindeswohl bietet sich daher das Kindergespräch als wichtige sozialarbeiterische Handlungsmöglichkeit an. Ausgehend davon wird die Frage beantwortet, inwiefern die Beistandsperson das kontaktverweigernde Kind im Rahmen des Kindergesprächs stärken kann. Hierfür beleuchtet die Autorin den rechtlichen Rahmen der zivilrechtlichen Kindesschutzmassnahme. Gestützt auf aktuelle Fachliteratur werden theoretische Grundlagen zur Situation des Kindes hochstrittiger Eltern dargelegt, mögliche Ursachen einer Kontaktverweigerung diskutiert und wichtige Aspekte der Entwicklung und Bedürfnisse des 4- bis 12-jährigen Kindes beleuchtet. Abschliessend zeigt die Autorin sozialarbeiterische Beratungsmethoden auf, welche sich für das Kind im hochstrittigen Elternkonflikt eignen. Der Kindeswille ist ein zentrales Kriterium betreffend der Kontaktverweigerung, aber auch hinsichtlich der Stärkung des Kindes. Im Beratungsprozess müssen zuerst die Faktoren ermittelt werden, auf welche die Beistandsperson im Gespräch mit dem Kind positiv Einfluss nehmen kann. Mittels einer alters- und entwicklungsgerechten Gesprächsführung kann das Kind dann dabei unterstützt werden, Schutzfaktoren und Ressourcen auf- und auszubauen, damit es sich in seinem Erleben und Handeln gestärkt fühlt.
description: + Code Diss LU: hslusa basa be 2020 + Fussnote: Bachelorarbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit 2020 + NL-Code: NLLUHSA202002
title: Regional deformation imprints from anisotropy of magnetic susceptibility data – an example from the Raichur Schist Belt (Dharwar Craton, India)
Creators: name:  Biswas,   Santu
name:  Mamtani ,   Manish A
name:  Kontny ,   Agnes
name:  Hilgers ,   Christoph
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The Raichur Schist Belt (RSB) is a NW-SE trending late-Archaean greenstone belt that forms part of the supracrustal units lying over an older gneissic basement. Granites (ca 2.5 Ga) occur in the vicinity of the RSB. The metavolcanics and granites are both massive and lack a field foliation and/or lineation. To work out the time-relationship between emplacement, fabric development and regional deformation of the granite vis-à-vis metavolcanic rocks and regional deformation, we performed Anisotropy of Magnetic Susceptibility (AMS) studies. Mean magnetic susceptibility (Km) of the metavolcanics varies between 843 µSI and 57800 µSI units, while in the granite it is between 6.88 µSI and 45000 µSI units. Microstructural studies reveal that the rocks are deformed and AMS is mostly controlled by paramagnetic phases. Temperature-dependent magnetic susceptibility studies carried out so far establish that samples with Km>1260 µSI contain multidomain magnetite. In the metavolcanics, mean orientation of magnetic foliation is NNW-SSE; this is similar to D1/D2 regional fabric of Dharwar Craton. The magnetic lineation is doubly plunging (direction varying from NNW to SSE). This is a manifestation of D3 superposed on D1/D2 fabric in the metavolcanics of RSB inferred from magnetic fabric, the mesoscopic field evidence for which is lacking. Similar superposed deformation is also implied from the AMS data of granites. The region is replete with quartz veins and their orientation analysis with respect to the magnetic fabric is expected to provide further details about the kinematics of the rocks.
The effectiveness of instruction-oriented hypertext systems compared to direct instruction in e-learning environments
Creators: name: Chokri Barhoumi, Pier Giuseppe Rossi
Publisher: name: Zenodo
Year: 2013
Subjects: E-learning; Online teaching; Flexible online course design; Direct online course design; Cognitive flexibility; Hypertext systems

description: The use of hypertext systems for learning and teaching complex and ill-structured domain of knowledge has been attracting attention in design of instruction. In this context, an experimental research has been conducted to explore the effectiveness of instructional design oriented hypertext systems. Cognitive flexibility hypertext theory is compared to direct instruction course design without hypertext systems for teaching and learning Flash online course in e-learning environment. Researchers used an experimental approach conducted in the academic year 2010 with independent sample of students of an experimental group (73 students) compared to a control group (73 students) from a university class. The results show the effectiveness of the hypertext systems course design compared to direct online course design. Indeed, the results of cognitive performance have demonstrated that the average time to answer achievement tests is lower for flexible instruction compared to average time for direct instruction. The number of students’ accesses to learning resources in the e-learning platform is higher in case of flexible instruction compared to direct instruction. Results of the experimentation also demonstrate that there are significant differences between the experimental group and the control group, regarding the attitudes of students toward using flexible online course design based cognitive flexibility hypertext theory and direct online course design.
Analysis of bat humeri from Late Pleistocene Talara Tar Seeps of northwestern Peru, with paleoenvironmental implications
Creators: name: Moretto, Lauren
name: Lim, Burton K.
name: Cadenillas, Richard
name: Jean-Noël Martinez
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Moretto, L., B. K. Lim, R. Cadenillas, and J.-N. Martinez. 2016. Analysis of bat humeri from Late Pleistocene Talara Tar Seeps of northwestern Peru, with paleoenvironmental implications. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2017.1250097.
Supplementary Material for: A Hierarchical Generalized Linear Model in Combination with Dispersion Modeling to Improve Sib-Pair Linkage Analysis
Creators: name: Lee, W.
name: Kim, J.
name: Lee, Y.
name: Park, T.
name: Suh, Y.J.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Objective: We explored a hierarchical generalized linear model (HGLM) in combination with dispersion modeling to improve the sib-pair linkage analysis based on the revised Haseman-Elston regression model for a quantitative trait. Methods: A dispersion modeling technique was investigated for sib-pair linkage analysis using simulation studies and real data applications. We considered 4 heterogeneous dispersion settings according to a signal-to-noise ratio (SNR) in the various statistical models based on the Haseman-Elston regression model. Results: Our numerical studies demonstrated that susceptibility loci could be detected well by modeling the dispersion parameter appropriately. In particular, the HGLM had better performance than the linear regression model and the ordinary linear mixed model when the SNR is low, i.e., when substantial noise was present in the data. Conclusion: The study shows that the HGLM in combination with dispersion modeling can be utilized to identify multiple markers showing linkage to familial complex traits accurately. Appropriate dispersion modeling might be more powerful to identify markers closest to the major genes which determine a quantitative trait.
Monitoring and improving environmental performances in the pharmaceutical industry: the Zambon Switzerland case study
Creators: name: Fortin, Alessia
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020

description: Nell’industria farmaceutica e della chimica fine è molto difficile prestare attenzione agli impatti ambientali. Sfortunatamente, c’è una mancanza di legislazione e di regolamenti per la riduzione degli impatti negativi dell’industria farmaceutica sull’ambiente. Tuttavia, Zambon Svizzera SA ha già iniziato a prendersi cura dell’ambiente: si è dotata di un sistema di gestione ambientale secondo la normativa ISO 14001:2015. Inoltre, l’azienda vorrebbe continuare i suoi miglioramenti ambientali. Per fare ciò, questa tesi aiuta l’azienda a svolgere le seguenti attività: Costruzione di una dashboard sempre aggiornata per aiutare il monitoraggio degli impatti ambientali; Costruzione di una mappatura dei consumi dei singoli processi al fine d’individuare dove conviene intensificare il monitoraggio per garantire una maggiore accuratezza dei dati; Identificazione delle possibili aree di miglioramento e sviluppo di proposte d’intervento basate su analisi economiche e ambientali.
Le nuove tecnologie in aiuto all’apprendimento del disegno: creare un’immagine verosimile sfruttando i videogiochi
Creators: name: Tobler, Zeudy Barbara
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2021
Subjects: digitale
disegno
avatar
motivazione

description: Questa ricerca si situa nel contesto delle nuove tecnologie e del loro possibile utilizzo nella disciplina di Educazione visiva. L’approccio specifico della sperimentazione effettuata è quello di utilizzare strumenti informatici (iPad) per motivare l’allievo nella pratica del disegno. Il gruppo selezionato è una classe di quarta media, opzione (ODAS), composto da 13 allievi/e. Lo scopo del progetto è quello di comprendere quanto i nuovi mezzi informatici possano motivare e promuovere l’interesse nel disegno espressivo/rappresentativo da parte degli allievi, e allo stesso tempo aumentare la loro soddisfazione personale. In questo senso, ho sviluppato un percorso didattico introdotto attraverso un questionario, per comprendere se il tema scelto “i videogiochi” poteva essere applicabile in un’attività di disegno interessante per gli allievi. L’argomento scelto “il volto”, è stato suddiviso in tre fasi: l’analisi, il disegno a matita, il disegno digitale. Per rispondere alle domande di ricerca, è stato sottoposto al gruppo un questionario finale dove era chiesto di indicare, sotto forma descrittiva, le loro impressioni riguardanti l’utilizzo dei mezzi informatici. Ne è risultato l’entusiasmo di aver affrontato un’attività nuova, e il desiderio di poterla replicare. Gli allievi sono sempre più attenti e interessati ai nuovi media, e necessita sensibilizzarli all’uso fornendogli buone basi. Relatore: Mario Bottinelli Montandon.
[PDF] à partir de dergipark.org.tr The Effectiveness of WhatsApp Mobile Learning Activities Guided by Activty Theory on Students' Knowldege Management
Creators: name: Barhoumi, Chokri
Publisher: name: Zenodo
Year: 2015

description: This research paper explores the effectiveness of using mobile technologies to support a blended learning course titled Scientific Research Methods in Information Science. Specifically, it discusses the effects of WhatsApp mobile learning activities guided by activity theory on students' knowledge Management (KM). During the 2014 academic year, the researcher adopted an experimental approach-based comparison between an experimental group (34 students) and a control group (34 students). The learning process of the experimental group was based on continuity between 2 hours of in-class learning and 1 hour of learning activities that were mediated by WhatsApp instant messaging each week. The control group’s experience was 100% in-class with no app mediation. The researcher used the t-test to compare the means of the control and experimental groups in the test and the students’ attitudes at 0.05 alpha levels. This research paper is useful for exploring the effectiveness of mobile technologies in supporting blended learning courses.
User acceptance of the e-information service as information resource: A new extension of the Technology Acceptance Model
Creators: name: Barhoumi, Chokri
Publisher: name: Zenodo
Year: 2016

description: The purpose of this paper is to extend significantly the technology acceptance model (TAM) of Davis to design an extended TAM model to be used in the evaluation and assessment of e-information services for information research such as e-library services. The present TAM extension is based on two variables of behavioral intention: the perceived ease of use and perceived usefulness of a system. Furthermore, the user satisfaction, free access, information architecture, content richness, policies and rules, publishers’ quality, system self-efficacy and task technology fit were incorporated into the TAM to extend it with other factors theoretically motivated and would be of interest more generally.
Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts
Creators: name: Abbes Benmerache
name: Benteldjoune, Mounira
name: Abdulmagid Alabdul Magid
name: Abedini, Amin
name: Djemaa Berrehal
name: Kabouche, Ahmed
name: Gangloff, Sophie C.
name: Voutquenne-Nazabadioko, Laurence
name: Kabouche, Zahia
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A previously undescribed phenolic sulphate ester, potassium 34-dihydroxy-3-methoxybenzoic acid methyl ester-5-sulphate (1), along with nine known flavonoids, kaempferol-3-O-potassium sulphate-4′,7-dimethyl ether (2), kaempferol-4′,7-dimethyl ether (3), rhamnocitrin-3-O-potassium sulphate (4), rhamnocitrin (5), kaempferol (6), quercetin (7), afzelin (8), quercetin-3-O-α-l-rhamnopyranoside (9) and luteolin-3′-O-potassium sulphate (10) were isolated from the aerial parts of Tamarix balansae. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. The antibacterial assay against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa bacteria showed a good activity for 2, 3, 7 and 9, with MICs ranging from 62.5 to 250 μg/mL. The abilities of these compounds to scavenge the DPPH were evaluated. Compounds 1, 7, 9 and 10 exhibited a good antiradical activity potential with IC50 values ranging from 3.0 to 115.5 μg/mL, compared with ascorbic acid (IC50 7.4 μg/mL) which was used as positive control.
title: CFPR: interview avec unine19a08m
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.9ac4k3tw.v1#7e28b09cf9244dced54e4c878f4a1c3db7b96bc9
title: Analysis of repeated measures in clinical trials using summary statistics
Creators: name: Frison, LJ
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1994

description: This thesis is concerned with statistical methodology for randomized clinical trials with repeated measurements over time, as regards both data analysis and the implications for study design. The inherent within-subject dependencies for repeated measurements necessitate analyses that take account of their covariance structure. There exists a whole battery of methods for analysing repeated measures designs, ranging from very simple (e.g. separate t-tests at each time-point) to very complicated (e.g. multi-level models with arbitrary error structures), but I will focus on "the summary statistic approach" which has recently become increasingly popular. When interest centres around the average response to treatment over time, a logical choice of summary statistic is the mean of each subject's post-randomisation measurements, with appropriate adjustment for pre-treatment measurements. Among the class of "mean summary statistics" analysis of covariance (ANCOVA) is shown to be superior to its competitors. In particular, variance formulae are derived both under a general covariance structure and more specific cases (e.g. compound symmetry) , allowing direct comparisons of efficiency among different summary statistics and repeated measures designs. The importance of precise estimates of the pre-entry levels and the consequences for sample size requirements are emphasized. Some additional topics in relation to mean summary statistics, notably; the bias in estimation if pre-treatment means differ, the choice between additive or multiplicative models, and the summary statistic "area under the curve", are also investigated. For studies with restrictions on the range of baseline measurements the negative consequences incurred by "regression to the mean" are explored, especially regarding the variance for between-group comparisons. For a more general class of true treatment effects over time, the optimal linear summary statistic under any covariance structure is derived. Special interest is devoted to the case of linearly diverging mean treatment curves, where the optimal alternative to the comparison of slopes is defined. Asymptotic relative efficiencies are shown to be a useful tool when contrasting different designs and different summary statistics, both in the planning and reporting of repeated measures clinical trials. Finally, comparisons with other approaches are made, and recommendations given based on the need to balance theoretical considerations with practical matters.
Who Benefits? The Interactional Determinants of Microfinance’s Varied Effects
Creators: name: Beck, Erin
name: Aguilera, Michael
name: Schintz, James
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Science Policy

description: Since its emergence as a development tool, scholars and practitioners have questioned microfinance’s short- and long-term impacts but have had insufficient empirical evidence to assess them. To address this gap, this paper draws on mixed method research to assess the effects of microfinance loan and educational services over time. It explores why, even within the same microfinance institution (MFI), some borrowers benefit from microfinance services more than others in the short-term, and examines how this translates into long-term impacts. The article identifies understudied sources of intra-group variation: the diversity and choices of borrowers and MFI employees interacting with each other and their broader contexts.
Classification of Fermi Gamma-Ray Bursts Based on Machine Learning
Creators: name: Zhu, Si-Yuan
name: Sun, Wan-Peng
name: Ma, Da-Ling
name: Zhang, Fu-Wen
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gamma-ray bursts (GRBs) are typically classified into long and short GRBs based on their durations. However, there is a significant overlapping in the duration distributions of these two categories. In this paper, we apply the unsupervised dimensionality reduction algorithm called t-SNE and UMAP to classify 2061 Fermi GRBs based on four observed quantities: duration, peak energy, fluence, and peak flux. The map results of t-SNE and UMAP show a clear division of these GRBs into two clusters. We mark the two clusters as GRBs-I and GRBs-II, and find that all GRBs associated with supernovae are classified as GRBs-II. It includes the peculiar short GRB 200826A, which was confirmed to originate from the death of a massive star. Furthermore, except for two extreme events GRB 211211A and GRB 230307A, all GRBs associated with kilonovae fall into GRBs-I population. By comparing to the traditional classification of short and long GRBs, the distribution of durations for GRBs-I and GRBs-II do not have a fixed boundary. We find that more than 10% of GRBs-I have a duration greater than 2 seconds, while approximately 1% of GRBs-II have a duration shorter than 2 seconds.
description: 11 pages, 5 figures, revised version submitted to MNRAS
Analysis of technological, individual and community factors influencing the use of popular Web 2.0 tools in LIS education
Creators: name: Barhoumi, Chokri
Publisher: name: Zenodo
Year: 2017

description: This research paper aims to explore the technological, individual and community factors influencing the use of popular Web 2.0 tools in library and information science (LIS) education to prepare LIS students for Library 2.0. The study was guided by the activity theory (AT) and technology acceptance model (TAM) of Davis as a lens. The study reveals a set of factors concerning the technical tools, subjective perceptions, goals of online discussion, social presence within a community, rules for participation and roles of the participants that affect their online engagement patterns. Design/methodology/approach This study was performed during the 2015 academic year; it used a descriptive analytical research approach for exploring and analysing technological, individual and community factors influencing the use of the popular Web 2.0 tools in LIS education. Findings The results show that at the technological level …
Proposal: Extending WikiPathways to Improve Educational Capabilities
Creators: name: Windsor, Jacob
Publisher: name: figshare
Year: 2017
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 80301 Bioinformatics Software

description: Proposal for bachelor thesis titled "Extending WikiPathways to Improve Educational Capabilities"
Code Quest - Multiplayer
Creators: name: Cadoni, Matteo
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2023

description: Code Quest è un progetto con l’obiettivo di insegnare i principi fondamentali della programmazione agli studenti delle scuole medie e superiori. Nella presente tesi è stata sviluppata e introdotta nel progetto esistente la modalità multiplayer che arricchisce l’esperienza di gioco, presentando due modalità competitive e una cooperativa. Le modalità competitive prevedono una competizione uno contro uno all’interno di un’arena. Mentre la modalità cooperativa prevede il raggiungimento di un obiettivo comune. Rispetto al progetto di partenza sono state apportate diverse modifiche al sistema di movimento, tramite l’introduzione di una griglia che consente l’aggiornamento dinamico. Ciò ha permesso anche l’implementazione di strumenti di generazione procedurale per lo sviluppo dei livelli. Lo sviluppo del gioco è stato svolto utilizzando Unity. A supporto è stato implementato un servizio web composto da: un database, un server API REST e un’applicazione web, realizzati rispettivamente in Spring e ReactJS. La sicurezza e l’autenticazione sono stati gestiti tramite Keycloak che ha consentito di usare il protocollo OpenID Connect. Il risultato ottenuto è un gioco che fornisce una funzionalità multigiocatore che comprende due modalità operative, una competitiva e una cooperativa, e lo rende pronto alla fase di test nelle scuole. ____ Code Quest is a project with the goal of teaching the fundamentals of programming to middle and high school students. In this thesis, a multiplayer mode was developed and introduced into the existing project that enriches the game experience by presenting two competitive modes and one cooperative mode. The competitive modes involve one-on-one competition within an arena. While the cooperative mode involves achieving a common goal. Compared to the initial design, several changes have been made to the movement system, through the introduction of a grid that allows dynamic upgrading. This also allowed the implementation of procedural generation tools for level development. Game development was carried out using Unity. To support it, a web service was implemented consisting of: a database, a REST API server, and a web application, built in Spring and ReactJS, respectively. Security and authentication were handled using Keycloak, which allowed the OpenID Connect protocol to be used. The result obtained is a game that provides multiplayer functionality including two modes of operation, one competitive and one cooperative, making it ready for the testing phase in schools.
Molecular dynamic simulations study of the effect of salt valency on structure and thermodynamic solvation behaviour of anionic polyacrylate PAA in aqueous solutions
Creators: name: Kananben Hemantkumar Patel
name: Rajalakshmi Chockalingam
name: Upendra Natarajan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: The effect of salt concentration and valency on intermolecular structure and solvation thermodynamic properties of aqueous solution containing polyacrylicacid (PAA) chains and multi-valent salts calcium chloride (CaCl2) and aluminium chloride (AlCl3) as a function of charge density was investigated using atomistic molecular dynamic simulations with explicit solvent. Salt-free solution favours the self-association of uncharged (acidic form) PAA chains facilitated by inter-chain hydrogen bonds. The ionised (charged) PAA chains are not associated in salt-free aqueous solutions and undergo self-association in the salt solutions due to bridging effect induced by condensed salt ions in agreement with scattering investigations available in literature. The collapse behaviour of PAA in presence of CaCl2 and re-expansion behaviour of PAA chains in case of AlCl3 salt solutions are observed. The rigidity of PAA chains decrease with increase in salt concentration, in agreement with experimental results available in literature. The trivalent salt favours relatively the greater extent of shrinking of PAA chains as well as inter-chain interactions as compared to divalent salts as evident from radius-of-gyration, H-bond and pair-wise solvation enthalpy data. The conformation and hydration behaviour of the acid form of PAA chains are not significantly altered by added salt ions. The hydration behaviour of ionised PAA chains is significantly reduced by added salts due to screening effect of the condensed salt ions. The pair correlation functions of solutions species such as Ca2+, Al3+, Na+ and Cl− with respect to PAA oxygen show the greater affinity of PAA units with the higher valency Al3+ ions over Ca2+ and Na+ in solution. With increase in concentration of AlCl3 and CaCl2 salts, a decrease in effective charge density of ionised PAA chains is observed from the existence of unfavourable PAA–water, PAA–Ca2+ and PAA–Al3+ interactions.
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Creators: name: Rodríguez-Ubreva, Javier
name: Arutyunyan, Anna
name: Bonder, Marc Jan
name: Del Pino-Molina, Lucía
name: Clark, Stephen J
name: De La Calle-Fabregat, Carlos
name: Garcia-Alonso, Luz
name: Handfield, Louis-François
name: Ciudad, Laura
name: Andrés-León, Eduardo
name: Krueger, Felix
name: Català-Moll, Francesc
name: Rodríguez-Cortez, Virginia C
name: Polanski, Krzysztof
name: Mamanova, Lira
name: Van Dongen, Stijn
name: Kiselev, Vladimir Yu
name: Martínez-Saavedra, María T
name: Heyn, Holger
name: Martín, Javier
name: Warnatz, Klaus
name: López-Granados, Eduardo
name: Rodríguez-Gallego, Carlos
name: Stegle, Oliver
name: Kelsey, Gavin
name: Vento-Tormo, Roser
name: Ballestar, Esteban
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/208/177
/631/250/249/2512
/38/39
/13/21
/13/31
article

description: Funder: Spanish Ministry of Science and Innovation; grant number PID2020-117212RB-I00 / AEI / 10.13038/501100011033
description: Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. Monozygotic (MZ) twins discordant for CVID are uniquely valuable for studying the contribution of epigenetics to the disease. Here, we generate a single-cell epigenomics and transcriptomics census of naïve-to-memory B cell differentiation in a CVID-discordant MZ twin pair. Our analysis identifies DNA methylation, chromatin accessibility and transcriptional defects in memory B-cells mirroring defective cell-cell communication upon activation. These findings are validated in a cohort of CVID patients and healthy donors. Our findings provide a comprehensive multi-omics map of alterations in naïve-to-memory B-cell transition in CVID and indicate links between the epigenome and immune cell cross-talk. Our resource, publicly available at the Human Cell Atlas, gives insight into future diagnosis and treatments of CVID patients.
Interfractional renal and diaphragmatic position variation during radiotherapy in children and adults: is there a difference?
Creators: name: Dijk, Irma W. E. M. Van
name: Huijskens, Sophie C.
name: Jong, Rianne De
name: Visser, Jorrit
name: Fajardo, Raquel Dávila
name: Rasch, Coen R. N.
name: Alderliesten, Tanja
name: Bel, Arjan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Background: Pediatric safety margins are generally based on data from adult studies; however, adult-based margins might be too large for children. The aim of this study was to quantify and compare interfractional organ position variation in children and adults. Material and methods: For 35 children and 35 adults treated with thoracic/abdominal irradiation, 850 (range 5–30 per patient) retrospectively collected cone beam CT images were registered to the reference CT that was used for radiation treatment planning purposes. Renal position variation was assessed in three orthogonal directions and summarized as 3D vector lengths. Diaphragmatic position variation was assessed in the cranio-caudal (CC) direction only. We calculated means and SDs to estimate group systematic (Σ) and random errors (σ) of organ position variation. Finally, we investigated possible correlations between organ position variation and patients’ height. Results: Interfractional organ position variation was different in children and adults. Median 3D right and left kidney vector lengths were significantly smaller in children than in adults (2.8, 2.9 mm vs. 5.6, 5.2 mm, respectively; p p Conclusions: Interfractional renal and diaphragmatic position variation in children is smaller than in adults indicating that pediatric margins should be defined differently from adult margins. Underlying mechanisms and other components of geometrical uncertainties need further investigation to explain differences and to appropriately define pediatric safety margins.
title: 02_0591
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: CFPR: interview avec unine19a07m
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.fbc92bxe.v1#eef3f9b88c1a0a0fea43e52f9512a36c955af189
title: OFROM: interview avec ilcf22a15
Creators: name: Delafontaine, François
name: Johnsen, Laure-Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.7c39r52d.v2#4d690cd3d1a9a4a8ed5a17947538e5d0746b1e6f
Comparison of gastric-cancer radiotherapy performed with volumetric modulated arc therapy or single-field uniform-dose proton therapy
Creators: name: Mondlane, Gracinda
name: Gubanski, Michael
name: Lind, Pehr A.
name: Ureba, Ana
name: Siegbahn, Albert
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 60506 Virology

description: Background: Proton-beam therapy of large abdominal cancers has been questioned due to the large variations in tissue density in the abdomen. The aim of this study was to evaluate the importance of these variations for the dose distributions produced in adjuvant radiotherapy of gastric cancer (GC), implemented with photon-based volumetric modulated arc therapy (VMAT) or with proton-beam single-field uniform-dose (SFUD) method. Material and methods: Eight GC patients were included in this study. For each patient, a VMAT- and an SFUD-plan were created. The prescription dose was 45 Gy (IsoE) given in 25 fractions. The plans were prepared on the original CT studies and the doses were thereafter recalculated on two modified CT studies (one with extra water filling and the other with expanded abdominal air-cavity volumes). Results: Compared to the original VMAT plans, the SFUD plans resulted in reduced median values for the V18 of the left kidney (26%), the liver mean dose (14.8 Gy (IsoE)) and the maximum dose given to the spinal cord (26.6 Gy (IsoE)). However, the PTV coverage decreased when the SFUD plans were recalculated on CT sets with extra air- (86%) and water-filling (87%). The added water filling only led to minor dosimetric changes for the OARs, but the extra air caused significant increases of the median values of V18 for the right and left kidneys (10% and 12%, respectively) and of V10 for the liver (12%). The density changes influenced the dose distributions in the VMAT plans to a minor extent. Conclusions: SFUD was found to be superior to VMAT for the plans prepared on the original CT sets. However, SFUD was inferior to VMAT for the modified CT sets.
Time-Step Analysis of the DECC 2050 Calculator Pathways - data files
Creators: name: Barton, John
name: Thomson, Murray
name: McKenna, Eoghan
Publisher: name: Loughborough University
Year: 2017
Subjects: subject: 90608 Renewable Power and Energy Systems Engineering (excl. Solar Cells)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 91305 Energy Generation, Conversion and Storage Engineering
subject: FOS: Mechanical engineering
subject: 90699 Electrical and Electronic Engineering not elsewhere classified

description: The DECC 2050 Calculator is an analysis of annual total energy use in the UK. File 'DECC Calculator Data Source' is a copy of version 3.4.6 of the published calculator. A further 10 Excel files are the FESA time-step analysis of the example low-carbon pathways, with their names. 'Results Summary3.xlsx' contains more graphs comparing pathways/scenarios. 'Figures For Paper v26.pptx' contains more graphs and diagrams. All these files relate to the paper with the same title and the same authors, published in the Institute of Mechanical Engineers, Part A: Journal of Power and Energy, special issue on the Realising Transition Pathways project.The software (the FESA analysis) is released under a GPL-3.0 licence but the other files are released under a CC-BY licence.
Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium.
Creators: name: Pinto, Andreia L
name: Rai, Ranjit K
name: Brown, Jonathan C
name: Griffin, Paul
name: Edgar, James
name: Shah, Anand
name: Singanayagam, Aran
name: Hogg, Claire
name: Barclay, Wendy S
name: Futter, Clare E
name: Burgoyne, Thomas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/326/596/4130
/631/80/304
/13/106
/13/51
/14/28
/14/19
article

description: Funder: G2P-UK National Virology Consortium funded by UKRI
description: Ultrastructural studies of SARS-CoV-2 infected cells are crucial to better understand the mechanisms of viral entry and budding within host cells. Here, we examined human airway epithelium infected with three different isolates of SARS-CoV-2 including the B.1.1.7 variant by transmission electron microscopy and tomography. For all isolates, the virus infected ciliated but not goblet epithelial cells. Key SARS-CoV-2 entry molecules, ACE2 and TMPRSS2, were found to be localised to the plasma membrane including microvilli but excluded from cilia. Consistently, extracellular virions were seen associated with microvilli and the apical plasma membrane but rarely with ciliary membranes. Profiles indicative of viral fusion where tomography showed that the viral membrane was continuous with the apical plasma membrane and the nucleocapsids diluted, compared with unfused virus, demonstrate that the plasma membrane is one site of entry where direct fusion releasing the nucleoprotein-encapsidated genome occurs. Intact intracellular virions were found within ciliated cells in compartments with a single membrane bearing S glycoprotein. Tomography showed concentration of nucleocapsids round the periphery of profiles strongly suggestive of viral budding into these compartments and this may explain how virions gain their S glycoprotein containing envelope.
КОНКУРЕНТОСПОСОБНОСТЬ КАК ИСТОЧНИК И ФАКТОР ЭФФЕКТИВНОСТИ ИМПОРТОЗАМЕЩЕНИЯ НА ПРОМЫШЛЕННЫХ РЫНКАХ
Creators: name: Мартыненко Оксана Владимировна
Publisher: name: Практический маркетинг
Year: 2020
Subjects: промышленная конкурентоспособность; национальный рынок машиностроительной продукции АПК; импортозамещение.

description: Цель работы – исследование возможностей реализации отраслевой стратегии импортозамещения на крупнейших внутренних рынках промышленной продукции производственнотехнического назначения. Методология работы включила в себя кабинетное исследование существующих отраслевых и корпоративных усилий в части роста конкурентоспособности продукции и субъектов российского сельскохозяйственного машиностроения, а также полевое исследование операционной эффективности и конкурентоспособности крупнейших участников рынка и их ожиданий относительно перспектив структурного сдвига во внутреннем потреблении сельскохозяйственной техники. К числу основных результатов авторского исследования был отнесен вывод об ухудшении отраслевой и маркетинговой конъюнктуры российского сельскохозяйственного машиностроения, несмотря на единичные попытки организации производства современных и конкурентоспособных на международном уровне образцов сельскохозяйственной техники. Отечественные производители выживают в режиме промышленной сборки на фоне несравнимых маркетинговых возможностей иностранных производителей. Отмечена обоснованная осторожность в оценке производителями перспектив эффективности импортозамещающих усилий в условиях отсутствия нормальных воспроизводственных процессов и их финансирования. Область применения результатов: отраслевая программа роста конкурентоспособности российского сельскохозяйственного машиностроения и программа импортозамещения техники АПК на внутреннем российском рынке.