cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-Armed Bandit Test Case Prioritization in Continuous Integration Environments: A Trade-off Analysis
Creators: name: Prado Lima, Jackson A.
name: Vergilio, Silvia R.
Publisher: name: Zenodo
Year: 2020
Subjects: Test Case Prioritization
Continuous Integration environments
Multi-Armed Bandit

description: Video presentation of the SAST@CBSoft'20 paper 'Multi-Armed Bandit Test Case Prioritization in Continuous Integration Environments: A Trade-off Analysis'. Abstract. Continuous Integration (CI) practices lead the software to be integrated and tested many times a day, usually subject to a test budget. To deal with this scenario, cost-effective test case prioritization techniques are required. COLEMAN is a Multi-Armed Bandit approach that learns from the test case failure-history the best prioritization order to maximize early fault detection. Reported results show that COLEMAN has reached promising results with different test budgets and spends, in the worst case, less than one second to execute. However, COLEMAN has not been evaluated against a search-based approach. Such an approach can generate near-optimal solutions but is not suitable to the CI budget because it takes too long to execute. Considering this fact, this paper analyses the trade-offs of the COLEMAN solutions in comparison with the near-optimal solutions generated by a Genetic Algorithm (GA). We use measures, which better fit with time constraints: Normalized Average Percentage of Faults Detected (NAPFD), Root-Mean-Square-Error (RMSE), and Prioritization Time. We use seven large-scale real-world software systems, and three different test budgets, 10%, 50%, and 80% of the total time required to execute the test set available for a CI cycle. COLEMAN obtains solutions near to the GA solutions in 90% of the cases, but scenarios with high volatility of test cases and a small number of cycles hamper the prioritization.
A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Creators: name: Sluss, Patrick M.
name: Pfeiffer, Ruth M.
name: Lu, Karen H.
name: Zhu, Claire S.
name: Lokshin, Anna E.
name: Lomakin, Aleksey
name: Vitonis, Allison
name: Srivastava, Sudhir
name: Scholler, Nathalie
name: Buys, Saundra S.
name: Fung, Eric T.
name: McIntosh, Martin W.
name: Hartge, Patricia
name: Ward, David C.
name: Symanowski, James T.
name: Moore, Lee E.
name: Urban, Nicole
name: Cramer, Daniel W.
name: Bast Jr., Robert C.
name: Mor, Gil
name: Marrangoni, Adele M.
name: Zhang, Zhen
name: Ransohoff, David F.
name: Patriotis, Christos
name: Pinsky, Paul F.
name: Berg, Christine D.
name: Skates, Steven J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few studies used pre-diagnostic samples to assess the potential of the panels for early detection. We conducted a multi-site systematic evaluation of biomarker panels using pre-diagnostic serum samples from the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) screening trial.
Identification and control for the effects of bioinformatic globin depletion on human RNA-seq differential expression analysis.
Creators: name: Sheerin, Dylan
name: Lakay, Francisco
name: Esmail, Hanif
name: Kinnear, Craig
name: Sansom, Bianca
name: Glanzmann, Brigitte
name: Wilkinson, Robert J
name: Ritchie, Matthew E
name: Coussens, Anna K
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: subject: Model organisms
subject: Infectious Disease
subject: Human Biology & Physiology
subject: Immunology
subject: FOS: Clinical medicine

description: When profiling blood samples by RNA-sequencing (RNA-seq), RNA from haemoglobin (Hgb) can account for up to 70% of the transcriptome. Due to considerations of sequencing depth and power to detect biological variation, Hgb RNA is typically depleted prior to sequencing by hybridisation-based methods; an alternative approach is to deplete reads arising from Hgb RNA bioinformatically. In the present study, we compared the impact of these two approaches on the outcome of differential gene expression analysis performed using RNA-seq data from 58 human tuberculosis (TB) patient or contact whole blood samples-29 globin kit-depleted and 29 matched non-depleted-a subset of which were taken at TB diagnosis and at six months post-TB treatment from the same patient. Bioinformatic depletion of Hgb genes from the non-depleted samples (bioinformatic-depleted) substantially reduced library sizes (median = 57.24%) and fewer long non-coding, micro, small nuclear and small nucleolar RNAs were captured in these libraries. Profiling published TB gene signatures across all samples revealed inferior correlation between kit-depleted and bioinformatic-depleted pairs when the proportion of reads mapping to Hgb genes was higher in the non-depleted sample, particularly at the TB diagnosis time point. A set of putative "globin-fingerprint" genes were identified by directly comparing kit-depleted and bioinformatic-depleted samples at each timepoint. Two TB treatment response signatures were also shown to have decreased differential performance when comparing samples at TB diagnosis to six months post-TB treatment when profiled on the bioinformatic-depleted samples compared with their kit-depleted counterparts. These results demonstrate that failure to deplete Hgb RNA prior to sequencing has a negative impact on the sensitivity to detect disease-relevant gene expression changes even when bioinformatic removal is performed.
The minimum number of chains in a noncrossing partition of a poset
Creators: name: Chen, Ricky X. F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 06A07, 06A11, 05D05

description: The notion of noncrossing partitions of a partially ordered set (poset) is introduced here. When the poset in question is $[n]=\{1,2,\dots, n\}$ with the complete order of natural numbers, conventional noncrossing partitions arise. The minimum possible number of chains contained in a noncrossing partition of a poset clearly reflects the structural complexity of the poset. For the poset $[n]$, this number is just one. However, for a generic poset, it is a challenging task to determine the minimum number. Our main result in the paper is some characterization of this quantity.
description: This version contains more discussion on HCDs of posets in contrast to the journal version
(401801) Joseph Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Female pelvic floor relaxation and pelvic organ prolapse is associated with pubovisceral muscle avulsion: combined analysis of static and dynamic 3.0-T MR imaging
Creators: name: Zhou, Hua
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: Genital / Reproductive system female
subject: MR
subject: MR-Functional imaging
subject: Contrast agent-other
subject: Imaging sequences
subject: Observer performance
subject: Pelvic floor dysfunction

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To evaluate female pubovisceral muscle (PVM) avulsion and pelvic floor weakness with static and dynamic images based on 3.0-T MR, and correlate PVM avulsion to severity of pelvic floor relaxation...
title: The radiological appearance of cystic and cavitated metastatic lesions of the lung
Creators: name: Smorchkova, Olga
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Thorax
subject: CT-High Resolution
subject: Diagnostic procedure
subject: Cavitation
subject: Cysts
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: This survey was designed to illustrate the various imaging features of atypical pulmonary metastases, focusing mainly on the high-resolution computed tomography (HRCT) findings of cavitary lesions. Furthermore, the differential diagnosis between...
From Circuits to SoC Processors: Arithmetic Approximation Techniques & Embedded Computing Methodologies for DSP Acceleration
Creators: name: Leon, Vasileios
Publisher: name: arXiv
Year: 2023
Subjects: subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: The computing industry is forced to find alternative design approaches and computing platforms to sustain increased power efficiency, while providing sufficient performance. Among the examined solutions, Approximate Computing, Hardware Acceleration, and Heterogeneous Computing have gained great momentum. In this Dissertation, we introduce design solutions and methodologies, built on top of the preceding computing paradigms, for the development of energy-efficient DSP and AI accelerators. In particular, we adopt the promising paradigm of Approximate Computing and apply new approximation techniques in the design of arithmetic circuits. The proposed arithmetic approximation techniques involve bit-level optimizations, inexact operand encodings, and skipping of computations, while they are applied in both fixed- and floating-point arithmetic. We also conduct an extensive exploration on combinations among the approximation techniques and propose a low-overhead scheme for seamlessly adjusting the approximation degree of our circuits at runtime. Based on our methodology, these arithmetic approximation techniques are then combined with hardware design techniques to implement approximate ASIC- and FPGA-based DSP and AI accelerators. Moreover, we propose methodologies for the efficient mapping of DSP/AI kernels on distinctive embedded devices, i.e., the space-grade FPGAs and the heterogeneous VPUs. On the one hand, we cope with the decreased flexibility of space-grade technology and the technical challenges that arise in new FPGA tools. On the other hand, we unlock the full potential of heterogeneity by exploiting all the diverse processors and memories. Based on our methodology, we efficiently map computer vision algorithms onto the radiation-hardened NanoXplore's FPGAs and accelerate DSP & CNN kernels on Intel's Myriad VPUs.
description: PhD Dissertation, National Technical University of Athens
(401797) William Bruce Dickie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Congenital and acquired anomalies of splenic anatomy - review of literature
Creators: name: Ivanova, Elena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Anatomy
subject: Spleen
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Congenital
subject: Hyperplasia / Hypertrophy

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - To raise awareness of splenic atypical anatomical features. - To describe the most frequent and essential splenic variants. - To present imaging cases of rare splenic anomalies - polysplenia and intrahepatic...
title: Liver FNH embolisation in pediatric population - technical aspects and results
Creators: name: Rago, Piotr
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Gastrointestinal tract
subject: Interventional vascular
subject: Paediatric
subject: Catheter arteriography
subject: CT
subject: Embolisation
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Large symptomatic liver FNH tumors (>6,5cm in dia) are a known problem within the pediatric population. Patients with multiple FNHs constitute a less common group, such as patients after oncological treatment of tumors, e.g. retinoblastoma. Until...
On the Phase-Space Distribution of Bloch Eigenmodes for Periodic Point Scatterers
Creators: name: Griffin, Jory
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Consider the 3-dimensional Laplacian with a potential described by point scatterers placed on the integer lattice. We prove that for Floquet-Bloch modes with fixed quasi-momentum satisfying a certain Diophantine condition, there is a subsequence of eigenvalues of positive density whose eigenfunctions exhibit equidistribution in position space and localisation in momentum space. This result complements the result of Ueberschär and Kurlberg who show momentum localisation for zero quasi-momentum in 2-dimensions, and is the first result in this direction in 3-dimensions.
description: 16 pages, 2 figures
Local atomic stacking and symmetry in twisted graphene trilayers
Creators: name: Craig, Isaac M.
name: Van Winkle, Madeline
name: Groschner, Catherine
name: Zhang, Kaidi
name: Dowlatshahi, Nikita
name: Zhu, Ziyan
name: Taniguchi, Takashi
name: Watanabe, Kenji
name: Griffin, Sinéad M.
name: Bediako, D. Kwabena
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Moiré superlattices formed from twisting trilayers of graphene are an ideal model for studying electronic correlation, and offer several advantages over bilayer analogues, including more robust and tunable superconductivity and a wide range of twist angles associated with flat band formation. Atomic reconstruction, which strongly impacts the electronic structure of twisted graphene structures, has been suggested to play a major role in the relative versatility of superconductivity in trilayers. Here, we exploit an inteferometric 4D-STEM approach to image a wide range of trilayer graphene structures. Our results unveil a considerably different model for moiré lattice relaxation in trilayers than that proposed from previous measurements, informing a thorough understanding of how reconstruction modulates the atomic stacking symmetries crucial for establishing superconductivity and other correlated phases in twisted graphene trilayers.
description: 22 pages, 5 figures
Genetic Variability of Smoking Persistence in African Americans
Creators: name: Benowitz, Neal L.
name: Redline, Susan
name: Styn, Mindi A.
name: Butler, Kenneth R.
name: Tong, Elisa K.
name: Buxbaum, Sarah G.
name: Wiggins, Kerri L.
name: Papanicolaou, George J.
name: Hitsman, Brian
name: Preis, Sarah R.
name: Kasberger, John L.
name: Goodloe, Robert J.
name: Gharib, Sina A.
name: Franceschini, Nora
name: Jorgenson, Eric
name: Bergen, Andrew W.
name: Levy, Daniel
name: Young, Taylor R.
name: White, Wendy B.
name: Spring, Bonnie
name: Hamidovic, Ajna
name: Meng, Yan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that measures smoking quantity, i.e. cigarettes per day. Additional association studies in diverse populations with different linkage disequilibrium (LD) patterns and an alternate phenotype, such as total tobacco exposure which accounts for intermittent periods of smoking cessation within a larger smoking period as measured in large cardiovascular risk studies, can aid the search for variants relevant to smoking behavior. For these reasons, we undertook an association analysis using a genotyping array that includes 2100 genes to analyze smoking persistence in unrelated African-American participants from The Atherosclerosis Risk in Communities (ARIC) study. A locus located ~ 4 Kb downstream from the 3’ UTR of the Brain-Derived Neurotrophic Factor (BDNF) significantly influenced smoking persistence. In addition, independent variants rs12915366 and rs12914385 in the cluster of genes encoding nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4) on 15q25.1 were also associated with the phenotype in this sample of African American subjects. To our knowledge, this is the first study to more extensively evaluate the genome in the African American population as a limited number of previous studies of smoking behavior in this population included evaluations of only single genomic regions.
title: Endometriosis and pelvic innervation: what the abdominal radiologist needs to know
Creators: name: Bavaresco, Ana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Computer Applications-General
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review somatic and visceral neuroanatomy of the female pelvis. To identify the pathway of the somatic nerves in volumetric T2 sequences, providing tips for their correct location and using anatomical landmarks sometimes obscure by abdominal...
(401798) Duncan Stewart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fayans functional for deformed nuclei. Uranium region
Creators: name: Tolokonnikov, S. V.
name: Borzov, I. N.
name: Kortelainen, M.
name: Lutostansky, Yu. S.
name: Saperstein, E. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Fayans energy density functional (EDF) FaNDF^0 has been applied to the nuclei around uranium region. Ground state characteristics of the Th, U and Pu isotopic chains, up to the two-neutron drip line, are found and compared with predictions from several Skyrme EDFs. The two-neutron drip line is found for FaNDF^0, SLy4 and SkM^* EDFs for a set of elements with even proton number, from Pb up to Fm.
description: 6 pages, 9 figures, to appear in the proceedings of the International Conference "Nuclear Structure and Related Topics", July 14 - July 18, 2015, Dubha, Russia
Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status
Creators: name: Barnes, Mack
name: Isaacs, Claudine
name: Sluss, Patrick M.
name: Mai, Phuong
name: Brewster, Wendy
name: Rodriguez, Gustavo C.
name: Greene, Mark H.
name: Drescher, Charles W.
name: Newland, William
name: Armstrong, Deborah K.
name: Davidson, Susan A.
name: Azodi, Masoud
name: Kauff, Noah D.
name: Fabian, Carol J.
name: Horick, Nora K.
name: Daly, Mary B.
name: Finkelstein, Dianne M.
name: Van Le, Linda
name: Skates, Steven J.
name: Berchuck, Andrew
name: Nayfield, Susan G.
name: Piedmonte, Marion
name: Domchek, Susan
name: Horowitz, Ira R.
name: Buys, Saundra S.
name: Cohn, David E.
name: Lu, Karen
name: Schorge, John O.
name: Kasten, Carol H.
name: Nerenstone, Stacy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Previous screening trials for early detection of ovarian cancer in postmenopausal women have used the standard CA125 cut-point of 35 U/mL, the 98th percentile in this population yielding a 2% false positive rate, while the same cut-point in trials of premenopausal women results in substantially higher false positive rates. We investigated demographic and clinical factors predicting CA125 distributions, including 98th percentiles, in a large population of high-risk women participating in two ovarian cancer screening studies with common eligibility criteria and screening protocols.
Friedrichs Diagrams -- Bosonic and Fermionic
Creators: name: Brooks, Morris
name: Lill, Sascha
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81Q12, 81S05, 81T18

description: We give a mathematically precise review of a diagrammatic language introduced by Friedrichs in order to simplify computations with creation and annihilation operator products. In that language, we establish explicit formulas and algorithms for evaluating bosonic and fermionic commutators. Further, as an application, we demonstrate that the non-linear Hartree dynamics can be seen as a subset of the diagrams arising in the time evolution of a Bose gas.
description: 26 pages, 11 figures. An important typo in Theorem 2.3, (23) has been fixed with respect to the previous version
The four-genus of connected sums of torus knots
Creators: name: Livingston, Charles
name: Van Cott, Cornelia A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25

description: We study the four-genus of linear combinations of torus knots: aT(p,q) # -bT(p',q'). Fixing positive p, q, p', and q', our focus is on the behavior of the four-genus as a function of positive a and b. Three types of examples are presented: in the first, for all a and b the four-genus is completely determined by the Tristram-Levine signature function; for the second, the recently defined Upsilon function of Ozsvath-Stipsicz-Szabo determines the four-genus for all a and b; for the third, a surprising interplay between signatures and Upsilon appears.
description: 18 pages; 6 figures. Typo corrected
Dynamical fluctuations of random walks in higher-order networks
Creators: name: Di Gaetano, Leonardo
name: Carugno, Giorgio
name: Battiston, Federico
name: Coghi, Francesco
Publisher: name: arXiv
Year: 2023
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Although higher-order interactions are known to affect the typical state of dynamical processes giving rise to new collective behavior, how they drive the emergence of rare events and fluctuations is still an open problem. We investigate how fluctuations of a dynamical quantity of a random walk exploring a higher-order network arise over time. \newtext{In the quenched case, where the hypergraph structure is fixed, through large deviation theory we show that the appearance of rare events is hampered in nodes with many higher-order interactions, and promoted elsewhere. Dynamical fluctuations are further boosted in an annealed scenario, where both the diffusion process and higher-order interactions evolve in time. Here, extreme fluctuations generated by optimal higher-order configurations can be predicted in the limit of a saddle-point approximation.} Our study lays the groundwork for a wide and general theory of fluctuations and rare events in higher-order networks.
description: Main: 7 pages (5+appendix and biblio), 4 figures. SM: 11 pages, 10 figures
Self-consistent Theory of Finite Fermi Systems vs Skyrme-Hartree-Fock method. Spherical nuclei
Creators: name: Saperstein, E. E.
name: Tolokonnikov, S. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Recent results of the Fayans energy density functional (EDF) for spherical nuclei are reviewed. A comparison is made with predictions of several Skyrme EDFs. The charge radii and characteristics of the first 2^+ excitations in semi-magic nuclei are briefly discussed. The single-particle spectra of doubly magic nuclei are considered in more detail. The phonon-particle coupling effects are analyzed including the so-called tadpole term.
description: 6 pages, 7 figures, to appear in the proceedings of the International Conference "Nuclear Structure and Relaited Topics", July 14 - July 18, 2015, Dubna, Russia. arXiv admin note: text overlap with arXiv:1401.1319
Variants Downstream of the Ornithine Decarboxylase Gene Influence Risk of Colorectal Adenoma and Aspirin Chemoprevention
Creators: name: Baron, John A.
name: Ahnen, Dennis J.
name: Barry, Elizabeth L.
name: Mott, Leila A.
name: Sandler, Robert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Increased mucosal polyamine levels and ornithine decarboxylase (ODC) activity are associated with an increased risk of colorectal neoplasia, and aspirin treatment reduces risk. Previous studies suggest that a single nucleotide polymorphism (SNP) in the promoter of the ODC gene (rs2302615) may be associated with adenoma risk and/or response to aspirin chemoprevention. However, a comprehensive investigation of common genetic variation in the region of ODC gene is lacking. Using a tag SNP approach, we investigated associations between genotype or haplotype and adenoma risk among a cohort of 792 white non-Hispanic participants in a randomized trial of aspirin. Generalized linear regression was used to compute relative risks (RRs) and 95% confidence intervals (95% CIs) adjusted for age and sex. The false discovery rate was used to account for multiple testing. Interactions terms were used to assess whether genotype modified the effect of aspirin treatment. Of 15 SNPs analyzed, 7 were statistically significantly associated with adenoma risk. However, in multiple SNP regression models, only 2 of these, located downstream of the gene, were independently associated with risk: rs11694911 (1.29 RR, 1.08–1.53 95% CI, P=0.005) and rs2430420 (1.20 RR, 1.03–1.40 95% CI, P=0.022). In addition, there was evidence that rs2430420 and rs28362380 modified the effect of aspirin treatment, whereas the previously investigated SNP, rs2302615, had no statistically significant main effect or interaction with aspirin treatment. Our findings suggest that common genetic variants located downstream (3’) of the ODC gene influence risk of colorectal adenoma and may also impact the efficacy of aspirin chemoprevention.
(401800) Charlotte Ann Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Contribution of ultrasound in non-traumatic and non-congenital osteoarticular pathology exploration in children’s limbs. About 52 cases.
Creators: name: NDAYISHIMIYE, NDAYISHIMIYE
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal system
subject: Ultrasound
subject: Imaging sequences
subject: Pathology

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The range of indications in adult musculoskeletal sonography has grown rapidly over the last two decades. Many sonographic studies typically requested in adults are now being requested in children. Unfortunately, many pediatric radiologists are not...
title: Scannographic aspects of neurogenic para-osteo-arthropathy
Creators: name: Siradji, Harouna Djataou
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: CT
subject: Education
subject: Demineralisation-Bone

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Neurogenic para-osteoarthropathies (NPOA) are ectopic ossifications ectopic ossifications, developed in the proximity of the large joints, which correspond to a process of ectopic neo-osteogenesis ectopic neo-osteogenesis occurring as a result of...
Many-body tunneling dynamics of Bose-Einstein condensates and vortex states in two spatial dimensions
Creators: name: Beinke, Raphael
name: Klaiman, Shachar
name: Cederbaum, Lorenz S.
name: Streltsov, Alexej I.
name: Alon, Ofir E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: In this work, we study the out-of-equilibrium many-body tunneling dynamics of a Bose-Einstein condensate in a two-dimensional radial double well. We investigate the impact of interparticle repulsion and compare the influence of angular momentum on the many-body tunneling dynamics. Accurate many-body dynamics are obtained by solving the full many-body Schrödinger equation. We demonstrate that macroscopic vortex states of definite total angular momentum indeed tunnel and that, even in the regime of weak repulsions, a many-body treatment is necessary to capture the correct tunneling dynamics. As a general rule, many-body effects set in at weaker interactions when the tunneling system carries angular momentum.
description: 26 pages, 9 figures
Implementing Responsible AI: Tensions and Trade-Offs Between Ethics Aspects
Creators: name: Sanderson, Conrad
name: Douglas, David
name: Lu, Qinghua
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computers and Society (cs.CY)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: K.4.0; I.2.m; D.2.10; C.4
subject: 68T01, 68T10

description: Many sets of ethics principles for responsible AI have been proposed to allay concerns about misuse and abuse of AI/ML systems. The underlying aspects of such sets of principles include privacy, accuracy, fairness, robustness, explainability, and transparency. However, there are potential tensions between these aspects that pose difficulties for AI/ML developers seeking to follow these principles. For example, increasing the accuracy of an AI/ML system may reduce its explainability. As part of the ongoing effort to operationalise the principles into practice, in this work we compile and discuss a catalogue of 10 notable tensions, trade-offs and other interactions between the underlying aspects. We primarily focus on two-sided interactions, drawing on support spread across a diverse literature. This catalogue can be helpful in raising awareness of the possible interactions between aspects of ethics principles, as well as facilitating well-supported judgements by the designers and developers of AI/ML systems.
Aspirin in the Chemoprevention of Colorectal Neoplasia: An Overview
Creators: name: Arber, Nadir
name: Elwood, Peter
name: Burn, John
name: Rothwell, Peter M.
name: Chan, Andrew T.
name: Chia, Whay Kuang
name: Schrör, Karsten
name: Hull, Mark A.
name: Baron, John A.
name: Logan, Richard F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Considerable evidence supports the effectiveness of aspirin for chemoprevention of colorectal cancer (CRC) in addition to its well-established benefits in the prevention of vascular disease. Epidemiologic studies have consistently observed an inverse association between aspirin use and risk of CRC. A recent pooled analysis of a long-term post-trial follow-up of nearly 14,000 patients from 4 randomized, cardiovascular disease prevention trials showed that daily aspirin treatment for about 5 years was associated with a 34% reduction in 20-year CRC mortality. A separate meta-analysis of nearly 3,000 patients with a history of colorectal adenoma or cancer in 4 randomized adenoma prevention trials demonstrated that aspirin reduced the occurrence of advanced adenomas by 28% and any adenoma by 17%. Aspirin has also been shown to be beneficial in a clinical trial of patients with Lynch syndrome, a hereditary CRC syndrome; in those treated with aspirin for at least 2 years, there was a ≥ 50% reduction in the risk of CRC commencing 5 years after randomization and after aspirin had been discontinued. A few observational studies have shown an increase in survival among patients with CRC who use aspirin. Taken together, these findings strengthen the case for consideration of long-term aspirin use in CRC prevention. Despite these compelling data, there is a lack of consensus about the balance of risks and benefits associated with long-term aspirin use, particularly in low-risk populations. The optimal dose to use for cancer prevention and the precise mechanism underlying aspirin’s anticancer effect require further investigation.
Towards a relation extraction framework for cyber-security concepts
Creators: name: Jones, Corinne L.
name: Bridges, Robert A.
name: Huffer, Kelly
name: Goodall, John
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Retrieval (cs.IR)
subject: Computation and Language (cs.CL)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences
subject: H.3.3

description: In order to assist security analysts in obtaining information pertaining to their network, such as novel vulnerabilities, exploits, or patches, information retrieval methods tailored to the security domain are needed. As labeled text data is scarce and expensive, we follow developments in semi-supervised Natural Language Processing and implement a bootstrapping algorithm for extracting security entities and their relationships from text. The algorithm requires little input data, specifically, a few relations or patterns (heuristics for identifying relations), and incorporates an active learning component which queries the user on the most important decisions to prevent drifting from the desired relations. Preliminary testing on a small corpus shows promising results, obtaining precision of .82.
description: 4 pages in Cyber & Information Security Research Conference 2015, ACM
Dietary Energy Balance Modulates Epithelial-to-Mesenchymal Transition and Tumor Progression in Murine Claudin-Low and Basal-like Mammary Tumor Models
Creators: name: Perou, Charles M.
name: Varticovski, Lyuba
name: Nogueira, Leticia
name: Dunlap, Sarah M.
name: Chiao, Lucia J.
name: Hursting, Stephen D.
name: Usary, Jerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Using novel murine models of claudin-low and basal-like breast cancer, we tested the hypothesis that diet-induced obesity (DIO) and calorie restriction (CR) differentially modulate progression of these aggressive breast cancer subtypes. For model development, we characterized two cell lines, “mesenchymal (M)-Wnt” and “epithelial (E)-Wnt,” derived from MMTV-Wnt-1 transgenic mouse mammary tumors. M-Wnt, relative to E-Wnt, cells were tumor-initiating cell (TIC)-enriched (62% vs 2.4% CD44high/CD24low), and displayed enhanced aldefluor-positivity, epithelial-to-mesenchymal transition (EMT) marker expression, mammosphere-forming ability, migration, invasion, and tumorigenicity (p
title: A comprehensive pictorial guide on imaging of pediatric hepatic lesions
Creators: name: Shalaby, Sherif
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Liver
subject: Oncology
subject: CT
subject: MR
subject: PET
subject: Biopsy
subject: Staging
subject: Infection
subject: Metabolic disorders
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: In this exhibit, we will illustrate a comprehensive pictorial review about the ultrasound, computed tomography (CT) and MRI imaging for differentiating the variable pediatric hepatic...
Makeham Mortality Models as Mixtures
Creators: name: Patricio, Silvio C.
name: Missov, Trifon I.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The Makeham term is a crucial element in mortality modeling, representing a constant additive hazard that addresses background mortality factors unrelated to aging. Widely used in mortality analysis, this term enables the capture of risks not linked to age-related decline. This paper aims to explore the relationship between Makeham mortality models and competing risk frameworks, investigating how Makeham models can be analyzed within the context of competing risks. It provides insights into the mathematical properties, interpretation, and applicability of Makeham models in modeling mortality risks associated with various causes of death. Additionally, it demonstrates that competing risk models can be represented as mixture models, enhancing understanding of mortality dynamics. The contribution lies in showing that Makeham mortality models, when represented as mixtures, offer a straightforward specification that can accommodate unobserved heterogeneity and distinguish between senescent and extrinsic mortality. By expressing Makeham models as a convex combination of probability distributions, the paper allows the estimation of premature mortality profiles, particularly at older ages, where most deaths are assumed to be senescent. It also facilitates the estimation of senescent mortality, which is crucial for studying the aging process.
title: CT guided biopsy in Paleoradiology
Creators: name: Čavka, Mislav
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Forensic / Necropsy studies
subject: CT
subject: Biopsy
subject: Connective tissue disorders

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Dragutin Gorjanović-Kramberger in 1901 has put Croatia on paleoradiological map of the world by scanning the fossilized remains of Neanderthal man from Krapina, Croatia. Since then radiological methods are used in paleopathology and paleoradiology...
title: Hippocampal subfields volume in schizophrenia and major depressive disorder: a systematic review and network meta-analysis
Creators: name: Sun, Yuan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: Outcomes analysis
subject: Psycho-oncology

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Approximately 80% of patients with schizophrenia (SCZ) experience depressive episodes in the early stages of the disease [1] and 27% of individuals with depression or anxiety disorders have psychotic symptoms [2]. A considerable overlap of...
${\mathsf D}^2={\mathsf H}+1/4$ with point interactions
Creators: name: Posilicano, A.
name: Reginato, L.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Let ${\mathsf D}$ and ${\mathsf H}$ be the self-adjoint, one-dimensional Dirac and Schrödinger operators in $L^{2}(\mathbb{R};\mathbb{C}^{2})$ and $L^{2}(\mathbb{R};\mathbb{C})$ respectively. It is well known that, in absence of an external potential, the two operators are related through the equality ${\mathsf D}^2 = ({\mathsf H} + \frac{1}{4}){\mathbb 1}$. We show that such a kind of relation also holds in the case of $n$-point singular perturbations: given any self-adjoint realization $\widehat {\mathsf D}$ of the formal sum ${\mathsf D}+\sum_{k=1}^{n}γ_{k}δ_{y_{k}}$, we explicitly determine the self-adjoint realization $\widehat{\mathsf H}$ of ${\mathsf H}{\mathbb 1}+\sum_{k=1}^{n}(α_{k}δ_{y_{k}}+β_{k}δ'_{y_{k}})$ such that ${\widehat{\mathsf D}}^2 = \widehat{\mathsf H} + \frac{\mathbb 1}{4}$. The found correspondence preserves the subclasses of self-adjoint realizations corresponding to both the local and the separating boundary conditions. Some connections with supersymmetry are provided. The case of nonlocal boundary conditions allows the study of the relation ${\mathsf D}^{2}={\mathsf H}+\frac14$ for quantum graphs with (at most) two ends; in particular, the square of the extension corresponding to Kirchhoff-type boundary conditions for the Dirac operator on the graph gives the direct sum of two Schrödinger operators on the same graph, one with the usual Kirchhoff boundary conditions and the other with a sort of reversed Kirchhoff ones.
description: final version, to appear in Operators and Matrices
title: Image quality evaluation of the newest generation of Digital Breast Tomosynthesis (DBT) imaging technology with 6mm slice thickness
Creators: name: Furuya, Yuko
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: Diagnostic procedure
subject: Image verification

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Digital breast tomosynthesis (DBT) combined with full-field digital mammography (FFDM) have demonstrated to improve diagnostic accuracy when compared to FFDM alone, has become widely used around the world [1,2]. Currently, the standard DBT systems...
Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps
Creators: name: Stoffel, Elena M.
name: Ruffin IV, Mack T.
name: Goel, Ajay
name: Marcon, Norman E.
name: Syngal, Sapna
name: Sen, Ananda
name: Hornick, Jason L.
name: Bresalier, Robert S.
name: Brenner, Dean E.
name: Yurgelun, Matthew B.
name: Baron, John A.
name: Turgeon, Danielle Kim
name: Boland, C. Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Colorectal cancers associated with Lynch syndrome (LS) are characterized by deficient DNA mismatch repair (MMR) function. Our aim was to evaluate the prevalence of microsatellite instability (MSI) and loss of MMR protein expression in LS-associated polyps. Sixty two colorectal polyps – 37 adenomas (APs), 23 hyperplastic polyps (HPs), and 2 sessile serrated polyps (SSPs) – from 34 subjects with germline MMR gene mutations were tested for MSI using a single pentaplex PCR for five mononucleotide repeat microsatellite markers, and also for expression of MLH1, MSH2, MSH6, and PMS2 proteins by immunohistochemistry (IHC). High-level MSI (MSI-H) was seen in 15/37 (41%) APs, 1/23 (4%) HPs, and 1/2 (50%) SSPs. Loss of MMR protein expression was seen in 18/36 (50%) APs, 0/21 HPs, and 0/2 SSPs. APs ≥8 mm were significantly more likely to demonstrate MSI-H (OR = 9.98, 95% CI: 1.52-65.65, p = 0.02) and deficient MMR protein expression (OR = 3.17, 95% CI: 1.20-8.37, p = 0.02) compared with those <8 mm. All (6/6) APs ≥10 mm demonstrated both MSI-H and loss of MMR protein expression by IHC. Our finding that the prevalence of MMR deficiency increases with the size of APs suggests that loss of MMR function is a late event in LS-associated colorectal neoplasia. Although testing large APs may be of value in the diagnostic evaluation of patients with suspected LS, the absence of an MMR deficient phenotype in an adenoma cannot be considered strong evidence against LS, as it is with colorectal carcinomas.
title: Development and validation of a CT-based radiomics signature for prediction of KRAS mutation in patients with locally advanced rectal cancer
Creators: name: Lin, Li-bo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT
subject: Decision analysis
subject: Radiation oncology in Developing Nations

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To develop a CT-based radiomic model for the prediction of KRAS mutation status in patients with colorectal...
Supporting Atlantic Blue Growth through stakeholder mapping
Creators: name: Depellegrin, D
name: Nesme, Y
name: Mendonça, E
name: Et Al
Publisher: name: Zenodo
Year: 2023
Subjects: Blue Economy, Innovation, ocean renewables, Atlantic Sea

description: Poster presentation performed within 7th PRIMaRE Conference (7th - 8th July 2020; University of Plymouth and Plymouth Marine Laboratory, UK) within the INTERREG Atlantic Area Project FANBEST (Funding Atlantic Network for Blue Economy Technology Transfer; https://fanbest.eu/).