cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kernel learning and applications in wireless localization
Creators: name: Wang, Qiaojun
Publisher: name: No Publisher Supplied
Year: 2016

description: Recent advances in mobile and pervasive computing have enabled accurate location  tracking of users wearing wireless devices indoors, where GPS isn’t available. Many  indoor WiFi location estimation techniques use received radio signal strength (RSS)  values from various access points to track users. In recent years, machine learning  techniques have been applied to this application and demonstrated the effectiveness  for tracking mobile devices. However, many existing systems suffer from the following  problems: (1) lack of labeled data, and (2) non-stationary data distribution. In this  thesis, we will describe our kernel learning-based method for solving the these challenges.  First, since it can be expensive to collect and label RSS training data in large  and complex buildings, we propose a semi-supervised learning approach to learn labelaware  base kernels, which are shown to be better aligned to the target comparing to  traditional base kernels spanned by the eigenvectors of the kernel matrix (or the graph  Laplacian); second, since the data distribution changes constantly as devices change  and over different time periods, we propose a transfer learning approach in Reproducing  Kernel Hilbert Space(RKHS) to adapt the data distribution changes. Experimental  results on real-world benchmark data demonstrate the encouraging performance of our  proposed schemes.
Additional file 1: of TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
Creators: name: Bemiller, Shane
name: McCray, Tyler
name: Allan, Kevin
name: Formica, Shane
name: Guixiang Xu
name: Wilson, Gina
name: Kokiko-Cochran, Olga
name: Crish, Samuel
name: Lasagna-Reeves, Cristian
name: Ransohoff, Richard
name: Landreth, Gary
name: Lamb, Bruce
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Increased tau pathology in 6-month hTau;Trem2−/− mice. A Western blot shows increased conformation specific anti-tau antibody MC1 reactivity in hTau;Trem2 −/− compared to hTau controls. B Increased ratio of Iba1 reactivity to AT8 Tau reactivity within cortices of hTau;Trem2 −/− mice. At least two independent experiments were performed for each analysis, n = 4–6 mice per genotype; equal males and females. Error bars represent SEM. *, P
Additional file 10: of Genomic divergence and cohesion in a species of pelagic freshwater bacteria
Creators: name: Hoetzinger, Matthias
name: Hahn, Martin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences

description: Parameters inferred from the first ClonalOrigin run. The parameters δ, θs and ρs are plotted along the genome. The computed median values, which have been used in the second ClonalOrigin run, are indicated by red, dashed lines. (PDF 28 kb)
Biology and ecology of forensically important blow flies (Diptera: Calliphoridae) in New Jersey with a focus on the black blow fly Phormia regina
Creators: name: Weidner, Lauren Marie
Publisher: name: No Publisher Supplied
Year: 2016

description: Blow flies (Diptera: Calliphoridae) are extremely beneficial insects to the decomposition process, making them an invaluable resource in the field of forensics. Being a newly developed field, many questions about blow fly biology and ecology remain unanswered. For my dissertation, I analyzed the biodiversity of forensically important blow flies across the state of New Jersey with a two – year survey using traps baited with beef liver, and examined their distribution across seasons and regions. Twelve species, spanning six  genera were collected during that time, with three dominant species collected, Lucilia sericata (Meigen), Lucilia coeruleiviridis (Macquart), and Phormia regina (Meigen). Following the survey, one site was chosen and validated using the same methodology, however, piglet carcasses were used as baits. Once assessing which species were present and common in New Jersey, I investigated their initial behavior with carrion in both diurnal and nocturnal conditions. Initial arrival times were recorded with video equipment, and their interactions with the carrion and other invertebrates were also examined. Due to the extensive work that has been conducted on L. sericata, I chose to focus my developmental analyses on P. regina and L. coeruleiviridis. Three experimental populations of P. regina were collected throughout New Jersey, and reared in two different environments. Their developmental characteristics (time in different developmental stages, pupal and adult weights) were investigated across regions and temperatures (20°C and 25°C) to determine if phenotypic plasticity is present among these populations. Not only were differences seen in phenotypic characteristics, this study provided the first developmental data on P. regina from the northeastern United States. Lucilia coeruleiviridis is a dominant species, not only in New Jersey but also across the United States; however, developmental data have been unavailable for this species, as they do not survive in colony. Using a sample collected from New Brunswick, New Jersey, I was able to analyze their development under 25°C, providing the first development data for this species.
Comparison of two models in differentially private distributed learning
Creators: name: Xie, Liyang
Publisher: name: No Publisher Supplied
Year: 2016

description: Designing medical systems that can automatically diagnose patient's conditions from test data can greatly improve healthcare systems. With the help of machine learning tools and differential privacy consideration, this system can be made more efficient and powerful. Empirical risk minimization is a common and useful technique with which we can obtain a good approximation of globally optimal classifier and thus give good statistical classification result. Firstly we introduce three models for medical data learning and two methods for distributed model. Then we compare a novel distributed classification method which we called the "feature method" with traditional averaging method on different real world data sets to gain an insight into their performance and properties. Next we give analysis on the performance of the feature method under non-private and differentially private conditions and conduct some experiments to draw several important conclusions from them. Finally we conclude that the distributed learning system we recommend achieve the best result among the three models.
Additional file 2: Figure S1. of Improving somatic variant identification through integration of genome and exome data
Creators: name: Vinaya Vijayan
name: Siu-Ming Yiu
name: Liqing Zhang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Virology

description: Sensitivity, precision and F1-scores using MuTect, SomaticSniper, VarScan2, VCMM, and J48 with A15E as the test set. A15K-A0BW-A152, was used as the training set for J48. (PDF 106Â kb)
Macrosteatotic hepatocyte defatting
Creators: name: Yarmush, Gabriel
Publisher: name: No Publisher Supplied
Year: 2016

description: Since there is a shortage of transplantable livers, the donor pool needs to be increased. One method to accomplish this is to recondition extended criteria donor grafts, a large portion of which are moderate to severe macrosteatotic livers. Transplantation of these livers often leads to primary nonfunction caused by an increased susceptibility to the effects of ischemia reperfusion injury (I/R) that result from the harvesting, transportation, and transplantation of the liver. Our lab has developed a novel procedure to recondition these livers through an ex vivo perfusion that will reduce the hepatic triglyceride content before the onset of the effects of I/R injury. To be feasibly performed in a clinical setting, the defatting must be completed in a matter of hours. While attempts to identify the ideal defatting cocktail in static culture only resulted in defatting livers after days of treatment, the rate of defatting increases to more a clinically relevant timeframe in a flow environment. My project focuses on understanding the differences between a static and flow environment and using this information to develop the ideal parameters for defatting. I hypothesize that using flow and appropriate defatting agents, steatotic hepatocytes can be defatted in a clinically relevant time of hours, without harming viability or function, to a level that reduces or eliminates increased sensitivity to I/R injury. In order to prove the hypothesis I will use the following 3 specific aims:    1. Develop a metabolic flux analysis model to explore defatting metabolic pathways.    2. Develop a computational fluid dynamics and kinetic model of a vitro flow reactor to optimize key transport parameters.    3. Validate the optimal conditions of flow has on the viability and function in hepatocyte cell lines.
Xiphidiola kivuensis Beier 1965
Creators: name: Naskrecki, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Xiphidiola
Xiphidiola kivuensis

description: Xiphidiola kivuensis (Beier, 1965)
Known only from the type locality in the Democratic Republic of Congo (Beier 1965). Material examined. — DEMOCRATIC REPUBLIC OF CONGO: Kivu, Mabuita, xii.1935, coll. Boutakoff - 1 male (holotype) (MRAC).
description: Published as part of Naskrecki, Piotr, 2008, New species of arboreal predatory katydids from West Africa (Orthoptera: Tettigoniidae: Meconematinae), pp. 1-28 in Zootaxa 1732 on page 17, DOI: 10.5281/zenodo.181351
Multifunctional nanoparticle-based approaches to enhance the treatment of cancer
Creators: name: Yin, Perry
Publisher: name: No Publisher Supplied
Year: 2016

description: Magnetic nanoparticles (MNPs) hold tremendous potential for various biomedical applications, including cancer diagnosis and treatment, owing to their unique ability to be manipulated by magnetic fields. In particular, cancer applications of MNPs have primarily utilized MNPs as MRI contrast agents, drug delivery vehicles, and as agents for magnetic hyperthermia. Significant progress has already been made in the advancement of MNP-based therapies to the clinic; however, tumor targeting and chemoresistance remain significant challenges. Addressing these challenges, this thesis focuses on the development of novel multifunctional MNP-based combination therapies.    In the first half of this thesis, novel MNP and magnetic core-shell nanoparticle (MCNP)-based combination therapies are developed to enhance the treatment of cancer by sensitizing cancer cells to subsequent therapies. To this end, MNPs are first developed for the dual purpose of delivering microRNA and inducing magnetic hyperthermia for the treatment of brain cancer. We demonstrate that the combination of lethal-7a microRNA (let-7a), which targets a number of survival pathways, can sensitize cancer cells to subsequent magnetic hyperthermia. Moreover, we demonstrate the use of MCNPs that are composed of a magnetic core and a mesoporous silica shell for the simultaneous delivery of let-7a and doxorubicin, wherein let-7a was found to sensitize breast cancer cells to subsequent doxorubicin chemotherapy.    In the second half of this thesis, to overcome poor tumor targeting, a stem cell-based gene therapy is developed. Specifically, MCNPs are reported for the dual purpose of delivering and activating a heat-inducible gene vector that encodes TNF-related apoptosis-inducing ligand (TRAIL) in adipose-derived mesenchymal stem cells (AD-MSCs) for the treatment of ovarian cancer. These engineered AD-MSCs retained their innate ability to home to tumors, making them ideal cellular carriers for cancer therapy. Moreover, mild magnetic hyperthermia resulted in the selective expression of TRAIL in the engineered AD-MSCs thereby inducing significant cancer cell death.    Overall, this thesis has demonstrated two multifunctional MNP-based approaches for cancer therapy: 1) combined MNP-based delivery of microRNA and magnetic hyperthermia to sensitize cancers to subsequent chemotherapy and 2) MCNP-based activation of heat-inducible genes in stem cells for targeted cancer treatment.
The synthesis of N-hydroxyoxindole-based photoactivatable fluorophores and its application for bioimaging
Creators: name: Yu, An
Publisher: name: No Publisher Supplied
Year: 2016

description: Photoactivatable fluorophores are essential tools for investigating the dynamic molecular interactions within biological systems with high spatiotemporal resolution. Herein, we report a class of photoactivatable fluorescent N-hydroxyoxindoles formed via intramolecular photocyclization of o-nitrophenyl ethanol (ONPE). These substituted oxindole fluorophores are substantially small in size, show ultra-high fluorescence enhancement (up to 800-fold) for photoactivation and exceptional biocompatibility, generating only water molecules as the photolytic side-product. Structure-activity relationship analysis revealed a strong correlation between the fluorescent properties of these fluorophores and the substituent groups, which can potentially serve as a guideline for designing fluorescent probes with desired photophysical properties. As a proof-of-concept study, a substituted ONPE with uncaging wavelength of 365-405 nm and excitation/emission at 515 and 620 nm respectively was developed. We then demonstrated the capability of this fluorescent probe in the selective imaging of human neural stem cells and HeLa cells. The rapid photoactivation capability of this probe, coupled with its high biocompatibility allowed for spatially-selective cell labeling with ignorable effect on the cell viability.
MobilityFirst Lite Over Things
Creators: name: Yu, Haoyang
Publisher: name: No Publisher Supplied
Year: 2016

description: New features like global reachability, mobility and multiple communication models are needed with the development of Internet of Things (IoT). However many approaches have been proposed to build an IoT platform based on IP-overlay architecture, but these solutions inheritly have constraints for new requirements in IP-based architecture.     MobilityFirst, a clean-slate future Internet architecture, was proposed in order to provide new features like global reachability, mobility and diverse communication models, using globally unique identifiers (GUID), global name resolution services (GNRS), etc; however, it is too bulky for computing-constraints and memory-limited devices.     In this paper, we are designing the MobilityFirst Lite (MF-Lite) Over Things architecture, which can run on a computing-limited embedded system for packet dissemination and data gathering. The MF-Lite, over things, protocol supports different communication patterns like unicast and multicast. The sensor motes used with GUID are globally reachable and have seamless connection in sensor-to-sensor and sensor-to-infrastructure.
Additional file 1: of TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
Creators: name: Bemiller, Shane
name: McCray, Tyler
name: Allan, Kevin
name: Formica, Shane
name: Guixiang Xu
name: Wilson, Gina
name: Kokiko-Cochran, Olga
name: Crish, Samuel
name: Lasagna-Reeves, Cristian
name: Ransohoff, Richard
name: Landreth, Gary
name: Lamb, Bruce
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Increased tau pathology in 6-month hTau;Trem2−/− mice. A Western blot shows increased conformation specific anti-tau antibody MC1 reactivity in hTau;Trem2 −/− compared to hTau controls. B Increased ratio of Iba1 reactivity to AT8 Tau reactivity within cortices of hTau;Trem2 −/− mice. At least two independent experiments were performed for each analysis, n = 4–6 mice per genotype; equal males and females. Error bars represent SEM. *, P
Xiphidiola pulchra Beier 1967
Creators: name: Naskrecki, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Xiphidiola
Xiphidiola pulchra

description: Xiphidiola pulchra Beier, 1967
This species was reported from Côte d’Ivoire by Beier (1967), and here it is reported for the first time from Ghana.
Material examined. CÔTE D’IVOIRE: Man (7°24'19''N, 7°32'51''W), 12.v.1964, coll. Gillon - 1 male (holotype) (MNHN); Toulepleu (6°34'29''N, 8°24'31''W), v.1964 - 1 female (allotype) (MNHN); GHANA: Eastern Region, Ajenjua Bepo Forest Reserve, elev. 300–320 m (6°22'2.3''N, 1°1'58''W), 26–30.viii. 2006, coll. P. Naskrecki, V. Awotwe-Pratt and M. Bakowski (Camp 1) - 1 female (MCZ).
description: Published as part of Naskrecki, Piotr, 2008, New species of arboreal predatory katydids from West Africa (Orthoptera: Tettigoniidae: Meconematinae), pp. 1-28 in Zootaxa 1732 on page 17, DOI: 10.5281/zenodo.181351
Controlled and sustained polymeric drug delivery systems for diabetic bone healing
Creators: name: Yu, Weiling
Publisher: name: No Publisher Supplied
Year: 2016

description: Diabetes involves chronic metabolic changes that can impair bone healing, including a prolonged inflammatory response after injury and changes in gene expressions of cells involved in bone healing. In this thesis, various controlled and sustained polymeric drug delivery systems were developed to enhance diabetic bone healing. First, a salicylic acid (SA)-based poly(anhydride ester) (SAPAE) that releases SA in a sustained and controlled manner was observed to mitigate local inflammation and significantly enhanced bone regeneration in diabetic rats. Second, insulin-encapsulating SAPAE microspheres were formulated to co-deliver SA and insulin, which are both active compounds for diabetic bone healing with clinically proven synergistic effects. Bulk double-emulsion and microfluidic techniques were both utilized to form the microspheres. The bulk method gives higher microsphere productivity, whereas the microfluidic method offers smaller microsphere size variance. Lastly, SAPAE porous scaffolds were formed to possess the desired SA release profile and porosity for diabetic bone healing – combining both the chemical and physical advantages.         These studies centered on controlled and sustained drug delivery systems for diabetic bone healing and utilized different formulation techniques to add favorable properties to the systems. With the unique properties of controlled and sustained SA release, the combination of multiple therapeutics (insulin and SA) and the integration of chemical and physical therapeutic properties (SA release and scaffold porosity), these systems are promising treatments or co-treatments for diabetic bone healing.
Optimization of encapsulation methods and conditions to maximize 1-MCP loading in modified beta-cyclodextrins
Creators: name: Zhang, Han
Publisher: name: No Publisher Supplied
Year: 2016

description: 1-methylcyclopropene (1-MCP) is a gas compound which can inhibit ethylene response in climacteric fruits. It is used to delay the ripening process and so to extend the shelf life of fresh produce. However, 1-MCP requires certain storage technology because it is highly unstable and flammable. Current storage technology is to use carrier systems such as α-cyclodextrin to encapsulate 1-MCP and thus protect and stabilize it. In the industry, high level of 1-MCP loading in carrier system is highly preferred to minimize the cost and maximize the efficiency. Therefore, encapsulation methods and conditions are critical for 1-MCP application as they determine the loading level of 1-MCP in the carrier system. The objective of this research is to identify optimum method and conditions to encapsulate 1-MCP into a newly-developed carrier system, modified β-cyclodextrin (MβCD), to maximize the loading of 1-MCP.   In this research, two encapsulation methods (solution method and solid method) and five condition factors (pH, MβCD concentration, temperature, 1-MCP concentration and encapsulation duration) were investigated to identify dominant factors for each method. 1-MCP concentration and encapsulation duration were found to be two dominant factors for both methods. Response Surface Methodology (RSM) was then used to optimize those two factors to identify optimum condition with maximum 1-MCP loading. Given by RSM, optimum condition of solution method was identified at (1.33X105 ppm, 21.2 hours) with maximum loading of 0.320% while optimum condition of solid method was at (1.39x105 ppm, 12.25 hours) with maximum loading of 0.529%. After testing the actual loading at optimum condition of the two methods, results showed 0.317% loading in solution method and 0.535% loading in solid method, which were -0.937% (solution method) and +1.13% (solid method) off to predicted values given by RSM respectively, confirming found optimum condition was valid.  In conclusion, solid encapsulation method gives maximum 1-MCP loading of 0.535% in MβCD at the condition of (12.25 hours, 1.39X105 ppm). The result proves the effectiveness of the chemical modification of β-CD and provides further understanding of different encapsulation mechanisms followed by those two methods.
Carbapenemase production and in-hospital mortality associated with multidrug-resistant bacteria: a retrospective study conducted in Granada, Spain
Creators: name: Redruello-Guerrero, Pablo
name: Fernández-Martínez, Nicolás Francisco
name: García-Marín, Cristina
name: Martín-delosReyes, Luis Miguel
name: Lorusso, Nicola
name: Millán-Cachinero, Carlos
name: del Carmen Valero-Ubierna, María
name: Rivera-Izquierdo, Mario
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Multidrug-resistant bacteria (MDR) represent a significant global health concern and vary in specific settings. Spain reported several annual deaths attributed to MDR bacteria, mainly carbapenemase-producing Enterobacterales. We aimed to characterise the incidence and temporal trends of MDR bacterial infections or colonisations reported within the province of Granada (data from five hospitals), and to investigate factors linked to clinical vulnerability. We conducted an observational retrospective study (2014–2022) using the Andalusian Epidemiological Surveillance System. We employed descriptive, bivariate analyses and geographical mapping. Multivariable logistic regression models were adjusted to identify factors associated with (1) carbapenemase-production and (2) in-hospital mortality. We included 1482 patients. The main microorganisms identified were Klebsiella spp., Escherichia spp. and Acinetobacter baumannii. Carbapenemases were detected in 23% of cases, and were associated with higher in-hospital mortality rates (OR: 1.92; 95% confidence interval (95% CI): 1.31–2.81) and male sex (OR: 1.50; 95% CI: 1.01–2.23). The overall in-hospital mortality rate was estimated at 18.1%. Infections caused by A. baumannii (OR: 2.11; 95% CI: 1.41–3.13) or carbapenemase-producing Klebsiella pneumoniae (OR: 2.11; 95% CI: 1.28–3.45) were associated with increased mortality. These findings contribute to our understanding of the characteristics associated with carbapenemase-producing and early mortality resulting from MDR bacteria. This study offers insights into the factors associated with clinical vulnerability, which may improve future preventive measures.
Flame synthesis of tungsten-doped titanium dioxide nanoparticles
Creators: name: Zhang, Yuqian
Publisher: name: No Publisher Supplied
Year: 2016

description: Metal-doped titanium dioxide nanoparticles can be employed in various applications, including dye-sensitized solar cells and gas sensors. Metal-doping is able to enhance the performance of titanium dioxide as photocatalysts by the dispersion of metal ions into the TiO2 matrix. In this work, tungsten-doped titanium dioxide nanoparticles are synthesized by a multiple diffusion flames burner using TTIP as the precursor (for titania) and tungsten mesh as the metal source (for doping). This novel method of using a metal mesh as precursor for doping is especially advantageous for low-vapor-pressure precursors and the entire nanoparticle synthesis process to be gas-phase based.  The effect of varying the tungsten loading rate is studied for synthesizing doped titanium dioxide with different tungsten amount. The results show that high loading rate of tungsten can trigger homogenous nucleation of WO3 prior to reaching the TTIP precursor loaded region, thereby leaving less tungsten ions to be doped into TiO2, when compared to the relatively lower tungsten loading rate configuration. Heat treatment at 973 K in an Ar atmosphere moves some of the tungsten out of the TiO2 structure, thus making a new WOx-TiO2 solid solution, while tungsten ions are reduced to lower oxidation states. Moreover the annealing process also increases the unit cell volume of W-doped TiO2, making the value closer to that of the un-doped TiO2. XRD, SEM, TEM, and XPS results are to prove the theory presented. UV Vis results show tungsten doping and heat treatment improve the absorbing ability of titanium dioxide in the visible light wavelength range significantly.
Relationships among subjective norms, gender, acculturation and the intention to engage in risky sexual behaviors among us-based Nigerians
Creators: name: Aloba, Olatubosun O.
Publisher: name: No Publisher Supplied
Year: 2016

description: Rationale: This study aimed to disentangle the complex interrelationships among subjective norms (SN), gender, acculturation, and the intention to engage in risky sexual behavior (RSB) among US-based Nigerians. It is well documented that Nigerian cultural norms inadvertently expose Nigerians in Nigeria to RSB in the forms of multiple sexual partnerships (MSP) and non-condom use. The extent to which Nigerians intend to continue with these culturally accepted beliefs and practices after immigration to the US, and the extent to which gender, level of acculturation, and SN are associated with RSB intentions among this group were unknown. It is crucial to understand this phenomenon because caring for negative outcomes of RSB such as unplanned pregnancies, STIs and HIV cost approximately $47 billion annually in the US. Method: The Theory of Planned Behavior (TPB) and the Acculturation Framework were used to explore hypothesized relationships. After approval from Rutgers University IRB for this cross-sectional, correlational study, 154 adult were recruited from five US-based Nigerian community Listservs.   Results: SN, PBC, and attitudes about condom use were independent predictors of condom use intention. SN by itself contributed 7% of the variance. Although SN was not an independent predictor of MSP intention, it was correlated to MSP intention. PBC for MSP, sexual preference, singleness, and assimilation were independent predictors of MSP. Overall, TPB constructs were significantly related to condom use and MSP intentions.   Conclusion: This is the first known study that has explored the intricate interrelationships among SN, gender, acculturation, and the intention to engage in RSB among US-based Nigerians. Findings indicated that the TPB propositions that asserted direct relationships between SN and intentions were empirically adequate. Conversely, the theorized interrelationship among background factors, SN, and intention were not supported. The theorized relationships of background factors as direct antecedents to SN and indirect antecedents to intention were less clear. Further studies are warranted. This study revealed important cultural subgroup differences in levels of acculturation, SN, and RSB intentions that underscore the premise that Blacks are not a monolithic group. These differences indicated that interventions targeted at US-based Nigerians might contribute to the prevention of RSB within this population. Findings laid the foundation for future interventions designed to modify behavioral intentions and SN that fostered RSB in at-risk groups, such as immigrants. The goal is to foster safer sexual behaviors and reduce negative consequences and associated treatment costs of RSB in this group.
Additional file 1: Table S1. of The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database
Creators: name: Tran, Long
name: Lai, Hang
name: Chihaya Koriyama
name: Uwatoko, Futoshi
name: Suminori Akiba
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: The association between birth weight and CNS tumor risk without adjustment for gestational age. The GA-unadjusted OR for high BW was 2.5 (95%CI = 1.2, 5.2) when compared to normal BW (2500–4000 g). (DOCX 21 kb)
MOESM2 of Gardening in the desert: a spatial optimization approach to locating gardens in rapidly expanding urban environments
Creators: name: Mack, Elizabeth
name: Daoqin Tong
name: Credit, Kevin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 2. Results of ANOVA tests for no garden, garden-adjacent, and garden-containing tracts. Three tables showing results of ANOVA analysis for each of the garden types and each of the variables of interest. Table includes the mean, standard deviation, and statistical significance for each variable/tract-type combination.
Regulation of Wnt delivery at intestinal stem cell niche
Creators: name: Das, Soumyashree
Publisher: name: No Publisher Supplied
Year: 2016

description: Communication between stem cells and its niche-supporting cells maintains the homeostasis of adult tissues. Wnt signaling is a critical regulator of stem cell niche, but the mechanism that governs Wnt-ligand delivery in this compartment has not been fully investigated. We identified that Wnt secretion is partly dependent on Rab8a-mediated anterograde transport of Gpr177/Wntless, a Wnt-specific transmembrane transporter. Gpr177 binds to Rab8a, depletion of which compromises Gpr177 traffic thereby weakening the secretion of multiple Wnts. Analyses of generic Wnt/-catenin targets in Rab8a knockout mouse intestinal crypts indicate reduced signaling activities. There, maturation of Paneth cell–a Wnt-dependent cell type is severely affected. Rab8a knockout crypts show an expansion of Lgr5+ and Hopx+ cells in vivo. However, in vitro, the knockout enteroids exhibit significantly weakened growth that can be partly restored by exogenous Wnts or GSK3 inhibitors. Immunogold labeling and surface protein isolation identified decreased plasma membrane localization of Gpr177 in Rab8a knockout Paneth cells and fibroblasts. On stimulation by exogenous Wnts, Rab8a deficient cells show ligand-induced Lrp6 phosphorylation and transcriptional reporter activation. Rab8a thus controls Wnt exocytosis in ligand producing cells and is critical for Paneth cell maturation. Additionally, deletion of Gpr177 alone from epithelium and underlying mucosal layer of intestine showed only subtle changes in stem cell number in vivo. However interestingly, significant deterioration in stem cell activity led to death of all Gpr177 null organoids within 4 days in culture. Taken together our data highlight profound tissue plasticity in vivo in response to stress induced by depletion of a stem cell niche signal.
Reputation management
Creators: name: Deat, Felix
Publisher: name: No Publisher Supplied
Year: 2016

description: The concept of reputation has emerged as a central feature in the governance of public administration as to appreciate and heighten the impressions of stakeholders. Reputation is considered to be a construct that organizations may use by actively influencing the perceptual processing of stakeholders, especially through a focus on distinct expectations and values. Within this management perspective of reputation, organizations and scholars have proposed and analyzed the eminent function of corporate branding. Schultz and de Chernatony (2002) assuredly note that “corporate branding provides a basis for a corporation to develop and express its distinctiveness through its consistent relationships with all stakeholders (p.105)”. Managing corporate branding refers to the deliberate and strategic process to construe and enhance the desired image of the organization to all stakeholders. Within this context, strategic communication, in the perspective of the utilitarian motivational function of brand management offers potential opportunity to not only enhance brand awareness but also prompt brand meaning.  This research seeks to examine whether local agencies can influence the attitudes and behaviors of their constituents in their favor by managing the image(s) associated with their institutions. To explore this issue, an exploratory mixed-methods framework was selected to investigate the following question: To what extent do branding cues, as communicated by local public agencies, influence citizen attitudes and behavior towards that particular agency?  Considering the objective of this dissertation, an exploratory, mixed-methods sequential design was used. More specifically, the research was carried out in the context of public schools in two phases: qualitative methods, including interviews with ten superintendents and the evaluation of more than 30 public school districts websites, were first used to collect important data, which were analyzed and the results were used to design the main quantitative experimental component of the study.  The findings advocate for a fit approach of reputation management, which implicates to strengthen what the organization stands for and the capacity to recognize it, by directly influencing stakeholders perceptual processing. Within the framework of public schools, strategic branding communication appears as a feasible and compelling approach to promote positive reputation. Specifically, this study demonstrates that through the direct effects on both components of brand equity, strategic branding communication is capable to enhance the efforts of public organizations to favor positive reputation and uphold favorable attitudes and behaviors.
Hypocacculus Bickhardt 1914
Creators: name: Lackner, Tomáš
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Histeridae
Hypocacculus

description: Subgenus Hypocacculus Bickhardt, 1914
Hypocacculus (Hypocacculus s. str.): REICHARDT (1926): 14; REICHARDT (1932): 28, 96; REICHARDT (1941): 156, 280; PEYERIMHOFF (1936): 228; KRYZHANOVSKIJ & REICHARDT (1976): 202, 205; MAZUR & KASZAB (1980): 52; VIENNA (1980): 171, 174; MAZUR (1984): 84; MAZUR (1997): 250; YÉLAMOS (2002): 308, 314; MAZUR (2004): 93.
Diagnosis. The subgenus Hypocacculus differs from the subgenera Colpellus and Nessus by the usually absent supraorbital striae, outwardly curved frontal stria, never forming acute angles above eyes and in general slightly coarser frontal punctation, never being ruguloselacunose. Pronotal hypomeron is with short setae; elytra in most cases without apical elytral stria, usually with punctation that is becoming denser towards elytral apex. Protibia usually with 6–8 teeth on outer margin, becoming progressively smaller apically.
Biology. See Biology of Hypocacculus s. l.
Distribution. About 12 species are known, most of them from the Palaearctic and Afrotropical Regions; Hypocacculus (Hypocacculus) spretulus is spread in the Palaearctic Region and Indo-Malayan Subregion and Hypocacculus (Hypocacculus) hyla reaches as far as New Guinea (MAZUR 1997).
Species examined. Hypocacculus (Hypocacculus) atrocyaneus (Schmidt, 1888), H. (H.) elongatulus elongatulus (Rosenhauer, 1856), H. (H.) elongatulus portusmagni (Coquerel, 1859), H. (H.) metallescens (Erichson, 1834), H. (H.) spretulus (Erichson, 1834), H. (H.) virens Dahlgren, 1973.
description: Published as part of Lackner, Tomáš, 2010, Review of the Palaearctic genera of Saprininae (Coleoptera: Histeridae), pp. 1-254 in Acta Entomologica Musei Nationalis Pragae (suppl.) (suppl.) 50 on pages 124-125, DOI: 10.5281/zenodo.4272127
Meloe Linne 1758
Creators: name: Bologna, Marco A.
name: Amore, Valentina
name: Pitzalis, Monica
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Meloidae
Meloe

description: Genus Meloe Linné, 1758
The genus, primarily Holarctic, is distributed in the Afrotropical Region with two subgenera, the nominate and Afromeleoe, both represented in Namibia. The Afrotropical species of this genus were revised by Bologna & Pinto (1998).
Meloe (Afromeloe) meridianus Péringuey, 1892 (Fig. 5X)
Meloe (Afromeloe) herero Schmidt, 1913
Distribution. Southern Mozambique, Namibia, northeastern South Africa, and Zimbabwe.
Material examined and literature records. [Ohangwena] Ondose: Mafa, 17.5000°S 16.0833°E (Bologna & Pinto 1998; SAMC). [Oshikoto]: Omuthiyagwiipundi: Ovampoland, Omaramba, 18.7500°S 16.9833°E (Péringuey 1909; Bologna & Pinto 1998; SAMC, holotype). [Otjozondjupa] Okahandja: Okahandja, 21.9833°S 16.9167°E (HNHM); Okahandja Gross Barmen, 22.1000°S 16.7500°E (CP). [Khomas] Windhoek Rural: Windhoek, Regenstein Farm 32, 22.7178°S 17.0317°E (Bologna & Pinto 1998; SMWN). [Karas] Keetmanshoop Rural: Noachabeb Farm 97, 27.3833°S 18.4667°E (Bologna & Pinto 1998; SMWN).
Other records: Damaraland (Schmidt 1913, type locaity of M. herero; Bologna & Pinto 1998; BMNH); Ovampoland (Cros 1937; Bologna & Pinto 1998); Namibia (Bologna & Pinto 1998; Bologna 2000a).
Remarks. Types of this species were examined at SAMC.
description: Published as part of Bologna, Marco A., Amore, Valentina & Pitzalis, Monica, 2018, Meloidae of Namibia (Coleoptera): taxonomy and faunistics with biogeographic and ecological notes, pp. 1-141 in Zootaxa 4373 (1) on page 95, DOI: 10.11646/zootaxa.4373.1.1, http://zenodo.org/record/1151722
Quantity over quality
Creators: name: Ford, Sarah A.M.
Publisher: name: No Publisher Supplied
Year: 2016

description: The mental health care crisis among military veterans in the United States has become a national concern in recent years, sparking questions regarding the quality of psychological care provided by veteran’s welfare programs. However, this is not a contemporary issue as the field of veteran’s psychological support has experienced a tumultuous evolution since the formation of the country. One of the most influential events that sparked this evolution was The Civil War. The mental health services provided to Civil War veterans immediately following the war was limited to severe cases of mental illness. Veterans who experienced mild to moderate symptoms relied on a range of sources for support, from family and community care to governmental assistance programs, which included soldier homes and the pension system. While these services didn’t directly address issues of mental health, they were often repurposed to assist psychologically disabled veterans. This patchwork system of aid provided veterans with medical care, shelter, and financial compensation. However, the pension system and soldier homes enforced eligibility requirements for services significantly limiting the accessibility of such aid. As the requirements for eligibility eased, more psychologically disabled veterans qualified for governmental aid. The remainder of veterans who continued to be unqualified for professional assistance turned to the only source of support left: their families and communities. Alone these sources were inadequate in providing the necessary support for many psychologically disabled veterans. Together, they created a patchwork system of support that provided Civil War veterans with a variety of care options with a range of basic treatments, which often proved to be ineffective by 19th century standards. This quantity over quality approach to treating psychological disorders expanded the coverage of care for veterans but it failed to improve its services leaving countless veterans without proper support. As contemporary veteran’s welfare programs continue to approach the mental health crisis with a similar philosophy emphasizing extensive yet ineffective treatments, it’s critical to understand how this system of care benefited and ultimately hindered psychologically disabled veterans.
HIV task shifting from physicians to nurses in Nigeria
Creators: name: Iwu, Emilia Ngozi
Publisher: name: No Publisher Supplied
Year: 2016

description: Rationale: With 25% global disease burden and only 3% global health workforce, the African region continues to account for the largest proportion of people living with HIV. While HIV task sharing between physicians and nurses, improved access to antiretroviral treatment, it led to African nurses acquiring roles beyond their traditional scope of practice. Numerous patient outcome research have identified the benefits of task sharing but research on nurse-related outcomes remains limited. This study attempts to fill the gap in knowledge by examining the demographic and setting correlates of self-efficacy and job satisfaction among Nigerian nurses in HIV task sharing roles.    Method: A pilot study was conducted using a focus group of ten expert nurses to ascertain the content validity and appropriateness of the study instruments. In the main study, 508 nurses in task sharing roles from 8 of 36 states in Nigeria were surveyed.     Result: A total of 399 surveys from tertiary (26%), secondary (46%) and primary (28%) facilities met criteria for analyses. The mean age and years in nursing practice were 42 (SD = 9.1) and 17 (SD = 9.2); 86% worked in Government hospitals, 76% were female and 70% Registered Nurse/Midwives. Over 95% received training and mentoring and 82% had previous HIV nursing experience. Self-Efficacy for task sharing had statistically significant correlation with female gender but negatively correlated with years in nursing practice. Job Satisfaction was statistically correlated with years in nursing practice; dual licensure as Nurse/Midwife; working in tertiary hospital; older age; male gender; duration of training and being mentored. Longer HIV nursing experience and working in secondary and primary health centers were found to increase the likelihood for job dissatisfaction.     Conclusion: Although more than 95% of the nurses received WHO recommended training and mentoring, they still faced system related challenges which negatively affected job satisfaction. Similar to reports in literature, these findings have critical implications for burnout, retention and quality service delivery. System-specific strategies such as: complementary staffing mix; continuing education; certification; updated policies, guidelines, scope of practice and curriculum that reflect current professional practice are needed to support nurses in expanded roles.
Exploring the role and perceived impact of clinical research nurses on pharmaceutical drug research and development
Creators: name: Keller, Rosemary
Publisher: name: No Publisher Supplied
Year: 2016

description: Many new drugs and treatments come to clinical practice as a result of the combined and coordinated efforts of skilled multidisciplinary team in the pharmaceutical drug research and development process. Although Clinical Research Nurses (CRNs) contribute to this process, the role of the CRN who works at many places along the continuum of pharmaceutical drug research and development has not been described from the CRN perspective.  The purpose of this study was to explore and describe the role experiences and perceived impact of the CRN, other than a research study coordinator, who works within the pharmaceutical industry. A focused ethnography methodology was used to examine the ordinary conscious experience of the work life of the CRN and their views of this non-traditional nursing role. Rutgers University IRB approval was obtained prior to study initiation. Twenty-one participants whose roles included, drug safety and risk management, clinical trials, regulatory management, and data dissemination, were interviewed to discover their perspectives of working in a non-traditional nursing role within pharmaceutical drug research and development.    Four main themes emerged from the data: Work environment, The goal of the role, Being in the role of clinical researcher and Being a nurse in the role of clinical researcher. The highly demanding, and changing work environment is based on a business rather than a clinical model.  In this setting the CRNs’ role was not about direct patient care but about caring for the larger population, both research subjects and product consumers. The goal of the CRN role is to ensure the integrity of clinical research so that only safe and effective treatments reach the clinical setting. The roles that nurses enact are varied but all require multidisciplinary collaboration and communication. Nurses in this role put patients in the forefront and use their nursing knowledge, training, and professional judgement to ensure the safe and ethical conduct of clinical research.    This study illustrates a unique role for nurses within the pharmaceutical industry to care for the public’s health. The changing business focused environment impacts their role but they use their nursing experience to advocate for study patients and patient consumers.