cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On descending cohomology geometrically
Creators: name: Achter, Jeff
name: Casalaina-Martin, Sebastian
name: Vial, Charles
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 14K30, 14C25, 14C30, 11G10, 11G35

description: In this paper, motivated by a problem posed by Barry Mazur, we show that for smooth projective varieties over the rationals, the odd cohomology groups of degree less than or equal to the dimension can be modeled by the cohomology of an abelian variety, provided the geometric coniveau is maximal. This provides an affirmative answer to Mazur's question for all uni-ruled threefolds, for instance. Concerning cohomology in degree three, we show that the image of the Abel--Jacobi map admits a distinguished model over the rationals.
description: 30 pages, AMS LaTeX, shortened exposition, some results strengthened. To appear in Composito Math. Material from appendix is now in arxiv:1610.06586; results on quadrics will appear elsewhere
Korea: the lady of kingdoms
Creators: name: Griffis, W. E. (William Elliot)
Publisher: name: No Publisher Supplied
Year: 1921

description: Griffis retells the bloody history of Korea and its position within East Asia, describing Korea as the "Belgium of Asia". The military history between Japan and Korea has been immortalized in monuments, often displaying the number of Korean lives taken by the Japanese before the 1900s. But even with this extended history of invasions and conquests, Korea is noted as a steadfast defender of their homeland, facing threats from the Japanese, Manchius, and Americans. Griffis illustrates Korea as being “Mercury” rather than “Mars,” as a peninsula that adopts, invites, and integrates cultures, technologies, and religions from other countries. It is this unique circumstance between major powers in East Asia that Korea was able to be resilient, and as a result, has become an anthropological site that is trying to maintain its autonomy.
Perfect sampling algorithm for Schur processes
Creators: name: Betea, Dan
name: Boutillier, Cédric
name: Bouttier, Jérémie
name: Chapuy, Guillaume
name: Corteel, Sylvie
name: Vuletić, Mirjana
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: 05A17, 05E10, 60C05, 60J10, 68U20, 82B20

description: We describe random generation algorithms for a large class of random combinatorial objects called Schur processes, which are sequences of random (integer) partitions subject to certain interlacing conditions. This class contains several fundamental combinatorial objects as special cases, such as plane partitions, tilings of Aztec diamonds, pyramid partitions and more generally steep domino tilings of the plane. Our algorithm, which is of polynomial complexity, is both exact (i.e. the output follows exactly the target probability law, which is either Boltzmann or uniform in our case), and entropy optimal (i.e. it reads a minimal number of random bits as an input). The algorithm encompasses previous growth procedures for special Schur processes related to the primal and dual RSK algorithm, as well as the famous domino shuffling algorithm for domino tilings of the Aztec diamond. It can be easily adapted to deal with symmetric Schur processes and general Schur processes involving infinitely many parameters. It is more concrete and easier to implement than Borodin's algorithm, and it is entropy optimal. At a technical level, it relies on unified bijective proofs of the different types of Cauchy and Littlewood identities for Schur functions, and on an adaptation of Fomin's growth diagram description of the RSK algorithm to that setting. Simulations performed with this algorithm suggest interesting limit shape phenomena for the corresponding tiling models, some of which are new.
description: 26 pages, 19 figures (v3: final version, corrected a few misprints present in v2)
Summary of Collective Actions
Creators: name: Djinlev, Vanja
name: Pearce, BinBin J.
Publisher: name: Zenodo
Year: 2022
Subjects: energy transition
collective action
social movements

description: This deliverable presents a key part of the content used in the training modules for the ENCLUDE Academy for Energy Citizen Leadership. It enables future Energy Citizen Leaders to understand ‘how’ and ‘why’ collective actions for social and societal transformation take place. Moreover, this deliverable can be seen as a resource base of past collective actions that can be used to understand how future collective actions can be carried out in the context of the energy transition. As such, this report may easily be used both within and outside of the project, by researchers interested in the topic of collective actions and energy transition.
A note on multipivot Quicksort
Creators: name: Iliopoulos, Vasileios
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 68P10, 68W20

description: We analyse a generalisation of the Quicksort algorithm, where k uniformly at random chosen pivots are used for partitioning an array of n distinct keys. Specifically, the expected cost of this scheme is obtained, under the assumption of linearity of the cost needed for the partition process. The integration constants of the expected cost are computed using Vandermonde matrices.
description: Author's accepted manuscript, 7 pages
Spin(7)-instantons, Cayley submanifolds, and Fueter sections
Creators: name: Walpuski, Thomas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We prove an existence theorem for Spin(7)-instantons, which are highly concentrated near a Cayley submanifold; thus giving a partial converse to Tian's foundational compactness theorem. As an application, we show how to construct Spin(7)-instantons on Spin(7)-manifolds with suitable local K3 Cayley fibrations. This recovers an example constructed by Lewis.
description: v3: published version. Section 3 draws heavily from a corresponding section in arXiv:1205.5350
GO_26, files from linear-scaling DFT and non-bonded parameters calculations
Creators: name: Pinto, Alexandre V.
Publisher: name: Zenodo
Year: 2022

description: Coordinates, topology, electron density cube file and files from Chargemol analysis for GO_26 obtained through Linear-Scaling Calculations in CP2K (check https://doi.org/10.1021/acs.jpcb.2c06037)
Theory of biochemical information processing with transients
Creators: name: Yadav, Manish
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Biochemical network
subject: Information processing
subject: Intracellular networks
subject: Time-varying signals
subject: Transients
subject: Non-autonomous system
subject: Dynamic transient memory
subject: Encoding and decoding
subject: Feedforward network
subject: 570
subject: 540
subject: Signalverarbeitung
subject: Signalvermittlung, Molekularbiologie

description: Cells in tissues and organisms operate in dynamic environments, continuously sensing and responding to time-varying chemical signals. In order to accurately interpret the complex information from their environment, biochemical networks in single cells actively process these extracellular signals in real-time. The current concept of biochemical computations places a strong focus on attractor based information processing in cells. Recent studies however have shown that cells generate completely opposite phenotypic responses depending upon frequency of the growth factor, independent of growth factor identity. This breaks down the steady-state description of biochemical information processing. Therefore, we propose to describe biochemical networks embedded in non-stationary environments as non-autonomous systems whose solutions are the dynamic input-dependent trajectories. We show that memory arising through metastable states will enable the system to integrate time-varying signals such that, inputs resulting in different phenotypic responses will be uniquely encoded in phase-space trajectories. The extracellular information of different phenotypes is spread throughout the large signaling networks and represented by characteristically different classes of phase-space trajectories. This encoded information will further be decoded downstream by early response genes (ERG) in real-time, where we show that the feed-forward structure of ERG is sufficient for this task.
Solving vehicle routing problem for waste disposal using modified differential evolution algorithm: A case study of waste disposal in Thailand
Creators: name: Narat Rattanawai
name: Sirawadee Arunyanart
name: Supachai Pathumnakul
Publisher: name: Faculty of Engineering, Khon Kaen University
Year: 2023
Subjects: Vehicle routing problem
Waste disposal
Modified differential evolution
Algorithm

description: Engineering and Applied Science Research, 50, 2, 155-162
A Taxonomy of Business Rule Organizing Approachesin Regard to Business Process Compliance
Creators: name: Corea, Carl
name: Delfmann, Patrick
Publisher: name: Enterprise Modelling and Information Systems Architectures (EMISAJ)
Year: 2020

description: Business Process Compliance (BPC) bridges the disciplines of Business Process Management and Compliance Management, and is aimed to ensure that business processes are aligned with laws and regulations. In this context, business rules are used as a central means to represent regulatory policies and consequently to (automatedly) verify, whether business process models abide by respective rules. While there has been a plethora of works regarding this actual verification of process models relative to business rules, we see a strong lack of works regarding the actual creation and maintenance of business rules. More precisely, many works assume sound sets of business rules as a basis for subsequent techniques. However, recent works suggest this assumption cannot be made in practice, and companies actually need to be supported in the scope of managing and organizing business rules, e.g., to remove redundant or contradictory rules. Organizing business rules is a mandatory prerequisite to BPC, as errors in business rules make these rule bases unusable and impede a subsequent verification of process compliance. However, the literature on business rule organization is sparse - especially its relation to BPC. We therefore investigate how to harmonize company efforts in business rule organization and BPC by the means of a systematic literature review. The main contribution of this work is a guideline which supports companies to select appropriate rule organization approaches based on company BPC needs. Also, we identify research gaps and propose a corresponding research agenda based on our findings.
description: Enterprise Modelling and Information Systems Architectures (EMISAJ), Vol. 15 (2020)
ARTISTIC EXPRESSION AND INTERPRETATION OF IMAGES IN THE STORIES OF NAZAR ESHANKUL.
Creators: name: Nasriyeva, Guzal
Publisher: name: Zenodo
Year: 2023

description: In his works, Nazar Eshanqul describes the human state of mind not with lively words, but depicts it through artistic means. Rebellion against nature, society, and humanity surrounding suffering is expressed through colors, smells, and pictures. In particular, "Art -1", "Art – 2", "Photograph of a ruined city", "Black book", "Coffin city", and "Monkey leading by the man" showcase this style of the writer.
Doubtful disputations: controversies in philosophical theology circa 1700
Creators: name: Fellows, Edward
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: English philosophical theology
18th century England
Scientific Revolution
René Descartes
Isaac Newton
John Toland
John Locke
Edward Stillingfleet
Henry Layton
Samuel Clarke
Anthony Collins

description: This research examines how controversial culture shaped philosophical theology in England circa 1700. This period saw numerous debates at the intersection of philosophy (including natural philosophy) and theology. Works in this area reflected the diverse intellectual inheritance of the seventeenth century, with its creative and destructive potential. For many, this period represents an important stage in the emergence of modern Western thought, conceived of as, for instance, the culmination of the Scientific Revolution, or a nascent stage of the Enlightenment. These movements have been variously characterised, including as an orderly progression towards more secular views, or as driven by conflict – perhaps between the ‘deists’ and orthodox thinkers, or between conservatives, and ‘Moderate’ and ‘Radical’ Enlightenment. There has, however, been no systematic study of the specific disputes themselves, or their immediate social and cultural context. This thesis aims to address this omission. It examines a series of ‘disputations’ in the broad domain of philosophical theology during this time, and explores how the culture of controversy shaped the ways thinkers participated in these and developed and presented their arguments. Part I, ‘Worlds made and destroy’d’, examines debates on the creation of the world, enlivened by efforts to combine sacred history with new physical theories of the Earth (prominently those of René Descartes, and Isaac Newton). Part II, ‘Between Faith and Reason’, explores polemical dialogues on the nature of knowledge and its limits, including those involving John Toland, John Locke and Edward Stillingfleet. Part III, ‘Matter and the Soul’, considers controversies on the nature of the soul, contrasting the polemical activities of the idiosyncratic Henry Layton with the more prominent correspondence between Samuel Clarke and the ‘deist’ Anthony Collins. The thesis concludes by reflecting on the ways in which debates in this area embodied and shaped broader intellectual change, seeking to present a more holistic and nuanced picture of the controversies within their immediate social and cultural context, rather than as part of a ‘secularisation narrative’.
Thermophysical Properties of the Lennard-Jones Fluid: Database and Data Assessment
Creators: name: Stephan, Simon
name: Thol, Monika
name: Vrabec, Jadran
name: Hasse, Hans
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 541 Physikalische Chemie
subject: Lennard-Jones fluid
subject: thermophysics
subject: molecular dynamics
subject: Monte Carlo simulation
subject: literature data

description: Literature data on the thermophysical properties of the Lennard-Jones fluid, which were sampled with molecular dynamics and Monte Carlo simulations, were reviewed and assessed. The literature data were complemented by simulation data from the present work that were taken in regions in which previously only sparse data were available. Data on homogeneous state points (for given temperature T and density ρ: pressure p, thermal expansion coefficient α, isothermal compressibility β, thermal pressure coefficient γ, internal energy u, isochoric heat capacity cv, isobaric heat capacity cp, Grüneisen parameter Γ, Joule–Thomson coefficient μJT, speed of sound w, Helmholtz energy a, and chemical potential) were considered, as well as data on the vapor–liquid equilibrium (for given T: vapor pressure ps, saturated liquid and vapor densities ρ′ and ρ″, respectively, enthalpy of vaporization Δhv, and as well as surface tension γ). The entire set of available data, which contains about 35 000 data points, was digitalized and included in a database, which is made available in the Supporting Information of this paper. Different consistency tests were applied to assess the accuracy and precision of the data. The data on homogeneous states were evaluated pointwise using data from their respective vicinity and equations of state. Approximately 10% of all homogeneous bulk data were discarded as outliers. The vapor–liquid equilibrium data were assessed by tests based on the compressibility factor, the Clausius–Clapeyron equation, and by an outlier test. Seven particularly reliable vapor–liquid equilibrium data sets were identified. The mutual agreement of these data sets is approximately ±1% for the vapor pressure, ±0.2% for the saturated liquid density, ±1% for the saturated vapor density, and ±0.75% for the enthalpy of vaporization—excluding the region close to the critical point.
Properties of the Homogeneous Cooling State of a Gas of Inelastic Rough Particles
Creators: name: Reyes, Francisco Vega
name: Santos, Andrés
name: Kremer, Gilberto M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this work we address the question of whether a low-density system composed of identical rough particles may reach hydrodynamic states (also called \textit{normal} states), even if energy is not conserved in particle collisions. As a way to measure the ability of the system to present a hydrodynamic behavior, we focus on the so-called homogeneous cooling state of the granular gas and look at the corresponding relaxation time as a function of inelasticity and roughness. We report computer simulation results of the sixth- and eighth-order cumulants of the particle velocity distribution function and study the influence of roughness on their relaxation times and asymptotic values. This extends the results of a previous work [Phys. Rev. E \textbf{89}, 020202(R) (2014], where lower-order cumulants were measured. Our results confirm that the relaxation times are not necessarily longer for stronger inelasticities. This implies that inelasticity by itself does not preclude hydrodynamics. It is also observed that the cumulants associated with the angular velocity distribution may reach very high values in a certain region of (small) roughness and that these maxima coincide with small orientational correlation points.
description: 8 pages; 4 figures; contributed paper at the 29th International Symposium on Rarefied Gas Dynamics (Xi'an, China, July 13-18, 2014)
What comes after the Sun? On the integration of soil biogeochemical pre-weathering into microplastic experiments
Creators: name: Büks, Frederick
name: Kaupenjohann, Martin
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 550 Geowissenschaften
subject: adverse effects of microplastic
subject: soil quality
subject: photochemical weathering with embrittlement
subject: weathering history of microplastic
subject: underground weathering
subject: pre-weathering under soil conditions

description: Recent studies have been engaged in estimating the adverse effects of microplastic (MP) on soil quality parameters. Mass concentrations of MP, as found in highly contaminated soils, have been shown to weaken the soil structure, and parts of the edaphon are adversely affected mainly by the <100 µm MP size fraction. However, the vast majority of these studies used pristine particles, which have surface characteristics different from those of environmental MP. Exposed to UV radiation, plastic undergoes photochemical weathering with embrittlement and the formation of surface charge, leading to an alteration of physiochemical behavior. When plastic particles then enter the soil environment, further aging factors appear with yet unknown efficacy. This little explored soil biogeochemical phase includes biofilm cover, decay with enzymes (as shown in laboratory experiments with both conventional and biodegradable plastics), contact with biotic and abiotic acids, oxidants, and uptake by the soil fauna that causes physical fragmentation. Such transformation of the surfaces is assumed to affect soil aggregation processes, soil faunal health, and the transport of plastic colloids and adsorbed solubles. This perspective article encourages us to consider the weathering history of MP in soil experiments and highlights the need for reproducing the surface characteristics of soil MP to conduct laboratory experiments with closer-to-nature results.
Pipelined Iterative Solvers with Kernel Fusion for Graphics Processing Units
Creators: name: Rupp, Karl
name: Weinbub, Josef
name: Jüngel, Ansgar
name: Grasser, Tibor
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Software (cs.MS)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences
subject: G.1.3
subject: 65F10 (Secondary), 65F50, 65Y05 (Primary), 65Y10

description: We revisit the implementation of iterative solvers on discrete graphics processing units and demonstrate the benefit of implementations using extensive kernel fusion for pipelined formulations over conventional implementations of classical formulations. The proposed implementations with both CUDA and OpenCL are freely available in ViennaCL and are shown to be competitive with or even superior to other solver packages for graphics processing units. Highest performance gains are obtained for small to medium-sized systems, while our implementations are on par with vendor-tuned implementations for very large systems. Our results are especially beneficial for transient problems, where many small to medium-sized systems instead of a single big system need to be solved.
description: 27 pages, 9 figures, 3 tables
Use of AI for the development of two new early drug discovery techniques: deep and transfer learning for LogP prediction and dimensionality reduction for sequence-based virtual screening
Creators: name: Chen, Yan-Kai
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: drug discovery
cheminformatics
machine learning
molecular physicochemical property
bioactivity prediction
molecular hydrophobicity

description: Prediction of small molecule physiochemical properties and their biological targets is extremely valuable in the effort to reduce costs and attrition rates within drug discovery. In-silico techniques are now routinely used to guide medicinal chemistry efforts, to prioritise compounds for synthesis and allow early rejection of anything undesirable in the early stages of drug discovery. The ‘big data’ revolution is impacting all fields of science with modern artificial intelligence and machine learning techniques becoming easily accessible due to advancements in computing power and toolkits. The application of these techniques is fundamentally poised to contribute and change the way biology, medicine and drug discovery are performed. In this thesis, machine learning and cheminformatics methods are applied for the prediction of small molecule physicochemical property and compound activity across a range of kinase targets. A neural network-based logP predictor, MRlogP, has been created and shown to outperform other freely available logP predictors for druglike small molecules. The creation of this predictor was achieved using a novel approach whereby the network was trained using a large amount of predicted data, and then further improved with a small dataset of highly accurate experimental measurements. This work has not only created a freely available performant tool for logP prediction on druglike molecules, but also demonstrated the application of techniques to tackle the lack of availability of high-quality data, commonly encountered in the context of drug discovery. This thesis work has also contributed to the establishment of a new branch of virtual screening with the creation of a sequence-based virtual screening platform, applying and improving upon the Drug Discovery Maps (DDM) technique to suggest active compounds for unexplored and orphan kinase targets without solved structures and known ligands. Potentially active compounds are prioritised using purely the target primary sequence. Identification of potentially privileged scaffolds for human and the Plasmodium falciparum (P.f.) targets demonstrate that this sequence-based virtual screening approach provides a fast and efficient route to apply machine learning methods for the identification of active compounds. Improvements implemented over the original DDM technique are shown to produce significantly better results than literature methods, offering a route to improved inhibitor predictions in the future for orphan and unexplored targets. DDM as a virtual screening platform for novel hit discovery has been validated with activity in a primary imaging assay.
A novel active learning technique for multi-label remote sensing image scene classification
Creators: name: Teshome Zegeye, Bayable
name: Demir, Begüm
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 006 Spezielle Computerverfahren
subject: active learning
subject: multi-label uncertainty
subject: multi-label diversity
subject: multi-label classification
subject: remote sensing

description: Copyright 2018 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
description: This paper presents a novel multi-label active learning (MLAL) technique in the framework of multi-label remote sensing (RS) image scene classification problems. The proposed MLAL technique is developed in the framework of the multi-label SVM classifier (ML-SVM). Unlike the standard AL methods, the proposed MLAL technique redefines active learning by evaluating the informativeness of each image based on its multiple land-cover classes. Accordingly, the proposed MLAL technique is based on the joint evaluation of two criteria for the selection of the most informative images: i) multi-label uncertainty and ii) multi-label diversity. The multi-label uncertainty criterion is associated to the confidence of the multi-label classification algorithm in correctly assigning multi-labels to each image, whereas multi-label diversity criterion aims at selecting a set of un-annotated images that are as more diverse as possible to reduce the redundancy among them. In order to evaluate the multi-label uncertainty of each image, we propose a novel multi-label margin sampling strategy that: 1) considers the functional distances of each image to all ML-SVM hyperplanes; and then 2) estimates the occurrence on how many times each image falls inside the margins of ML-SVMs. If the occurrence is small, the classifiers are confident to correctly classify the considered image, and vice versa. In order to evaluate the multi-label diversity of each image, we propose a novel clustering-based strategy that clusters all the images inside the margins of the ML-SVMs and avoids selecting the uncertain images from the same clusters. The joint use of the two criteria allows one to enrich the training set of images with multi-labels. Experimental results obtained on a benchmark archive with 2100 images with their multi-labels show the effectiveness of the proposed MLAL method compared to the standard AL methods that neglect the evaluation of the uncertainty and diversity on multi-labels.
Gene augmentation of CHM using non-viral episomal vectors in models of choroideremia.
Creators: name: Toualbi, Lyes
name: Toms, Maria
name: Almeida, Patrick Vingadas
name: Harbottle, Richard
name: Moosajee, Mariya
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Gene Expression
subject: Gene Expression
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Developmental Biology
subject: Developmental Biology
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Human Biology & Physiology
subject: Human Biology & Physiology
classificationCode: Model organisms
subject: Model organisms

description: Choroideremia (CHM) is an X-linked chorioretinal dystrophy leading to progressive retinal degeneration that results in blindness by late adulthood. It is caused by mutations in the CHM gene encoding the Rab Escort Protein 1 (REP1), which plays a crucial role in the prenylation of Rab proteins ensuring correct intracellular trafficking. Gene augmentation is a promising therapeutic strategy, and there are several completed and ongoing clinical trials for treating CHM using adeno-associated virus (AAV) vectors. However, late-phase trials have failed to show significant functional improvements and have raised safety concerns about inflammatory events potentially caused by the use of viruses. Therefore, alternative non-viral therapies are desirable. Episomal scaffold/matrix attachment region (S/MAR)-based plasmid vectors were generated containing the human CHM coding sequence, a GFP reporter gene, and ubiquitous promoters (pS/MAR-CHM). The vectors were assessed in two choroideremia disease model systems: (1) CHM patient-derived fibroblasts and (2) chmru848 zebrafish, using Western blotting to detect REP1 protein expression and in vitro prenylation assays to assess the rescue of prenylation function. Retinal immunohistochemistry was used to investigate vector expression and photoreceptor morphology in injected zebrafish retinas. The pS/MAR-CHM vectors generated persistent REP1 expression in CHM patient fibroblasts and showed a significant rescue of prenylation function by 75%, indicating correction of the underlying biochemical defect associated with CHM. In addition, GFP and human REP1 expression were detected in zebrafish microinjected with the pS/MAR-CHM at the one-cell stage. Injected chmru848 zebrafish showed increased survival, prenylation function, and improved retinal photoreceptor morphology. Non-viral S/MAR vectors show promise as a potential gene-augmentation strategy without the use of immunogenic viral components, which could be applicable to many inherited retinal disease genes.
Spectral multiplier theorems and averaged R-boundedness
Creators: name: Kriegler, Christoph
name: Weis, Lutz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics

description: Let $A$ be a $0$-sectorial operator with a bounded $H^\infty(Σ\_σ)$-calculus for some $σ\in (0,π),$ e.g. a Laplace type operator on $L^p(Ω),\: 1 < p < \infty,$ where $Ω$ is a manifold or a graph. We show that $A$ has a H{ö}rmander functional calculus if and only if certain operator families derived from the resolvent $(λ- A)^{-1},$ the semigroup $e^{-zA},$ the wave operators $e^{itA}$ or the imaginary powers $A^{it}$ of $A$ are $R$-bounded in an $L^2$-averaged sense. If $X$ is an $L^p(Ω)$ space with $1 \leq p < \infty,$ $R$-boundedness reduces to well-known estimates of square sums.
description: Error in the title corrected
Effective kinetic description of non-equilibrium dynamics in small and large collision systems
Creators: name: Werthmann, Clemens
Publisher: name: Universität Bielefeld
Year: 2022
Subjects: subject: 530

description: In current times, the study hadronic collisions is a prominent research field in experimental and theoretical physics. Simulations of hadronic collisions are typically based on a hydrodynamic description that relies on equilibration. But accurate depic- tions of the early time period or of collisions with few produced particles may require a non-equilibrium description of the dynamics. In this work we describe equilibrium and non-equilibrium effects in hadronic collisions ranging from small to large systems within model descriptions based on kinetic theory and compare to hydrodynamics. We focus on results for cooling due to longitudinal expansion and radial as well as anisotropic flow. We employ an effective kinetic description, based on the Boltzmann equation in the relaxation time approximation, to study the space-time dynamics and development of transverse flow of small and large collision systems. By combining analytical insights in the small opacity limit with numerical simulations at larger opacities, we are able to describe the development of transverse flow from very small to very large opacities. Suprisingly, we find that deviations between kinetic theory and hydrodynamics persist even in the limit of very large opacities, which can be attributed to the presence of the early pre-equilibrium phase. For decades hydrodynamics has been used as the main tool for simulating heavy ion collisions, being highly successful in describing their phenomenology. However, a priori it is not clear why this description should be as accurate as it is in simulating a system whose size is not necessarily large compared to the mean free path of its constituents, with possibly sizable local fluctuations involving large gradients and a far-from-equilibrium initial state. A rigorous global examination of possible problems of this description has yet to be performed. In this work, we present our results of comparing hydrodynamic and hybrid simulations to kinetic theory in a simplified dynamical model. We point out inaccuracies of hydrodynamical models and present modified setups that can improve them.
Identifying orbital angular momentum of vectorial vortices with Pancharatnam phase and Stokes parameters
Creators: name: Zhang, Dengke
name: Feng, Xue
name: Cui, Kaiyu
name: Liu, Fang
name: Huang, Yidong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this work, an explicit formula is deduced for identifying the orbital angular moment (OAM) of vectorial vortex with space-variant state of polarization (SOP). Different to scalar vortex, the OAM of vectorial vortex can be attributed to two parts: the azimuthal gradient of Pancharatnam phase and the product of the azimuthal gradient of orientation angle of SOP and relevant solid angle on the Poincaré sphere. With our formula, a geometrical description for OAM of light beams can be achieved under the framework of the traditional Poincaré sphere. Numerical simulations for two types of vectorial vortices have been carried on to confirm our presented formula and demonstrate the geometrical description of OAM. Furthermore, the finding will pave the way for precise characterization of OAM charge of vectorial vortices.
description: 10 pages, 5 figures
Ο ναζιστικός λόγος για την εκπαίδευση και την αγωγή: η περίπτωση της Χρυσής Αυγής
Creators: name: Τσαλταμπάση, Αικατερίνη Θωμά
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Ναζιστικός λόγος
Εκπαιδευτικός λόγος
Χρυσή Αυγή
Nazi discourse
Educational discourse
Golden Dawn

description: Η άνοδος των ακροδεξιών κομμάτων σε μία σειρά χωρών, καθώς και η συμμετοχή, σε κάποιες περιπτώσεις, σε κυβερνητικούς σχηματισμούς, ορίζει σε μεγάλο βαθμό την ευρωπαϊκή πολιτική σκηνή, σε μία περίοδο κατά την οποία ο ρατσιστικός λόγος εκφέρεται από τα πιο επίσημα, θεσμικά χείλη. Η εργασία, αφού κάνει μια εισαγωγή γι’ αυτήν τη σύνδεση, θα θυμίσει τις ιστορικές προϋποθέσεις της έξαρσης του εθνικισμού από τη δημιουργία των εθνών-κρατών, καθώς και τα αίτια γέννησης και γιγάντωσης του ναζισμού στη Γερμανία. Θα αναλύσει την κοινωνική βάση, τα μέσα και την ιδεολογία του και θα εξετάσει τον ρόλο της εκπαίδευσης ως ατμομηχανής προπαγάνδας και κοινωνικού ελέγχου από το Γ’ Ράιχ, σε μια περίοδο που η νεολαία έψαχνε για την εναλλακτική της ζοφερής κατάστασης που είχε διαμορφώσει η Δημοκρατία της Βαϊμάρης. Έπειτα, έχοντας εξετάσει αν η Χρυσή Αυγή είναι άλλο ένα ακροδεξιό ή ένα ναζιστικό κόμμα, θα προσπαθήσει να φωτίσει τον εθνικοσοσιαλιστικό χαρακτήρα της οργάνωσης, παρά την επίσημη στροφή της στον εθνικισμό, μετά το 1992. Για να γίνει αυτό, θα χρησιμοποιήσει τη Διακήρυξη Ιδεολογικών Αρχών της οργάνωσης, διερευνώντας αν ο λόγος της Χρυσής Αυγής για την Εκπαίδευση και την Αγωγή, όπως εκφράστηκε μέσα από τα κείμενα που απευθύνονταν στη νεολαία, επιβεβαιώνει τα δεκατρία κεφάλαια της Διακήρυξης.
description: The rise of far-right parties in a number of countries, as well as the participation, in some cases, in government formations, largely defines European politics, in a time when racist discourse is expressed from the most official, institutional lips. The paper, after making an introduction to this connection, will recall the historical presuppositions of the upsurge of nationalism since the creation of nation-states, as well as the causes of the birth and growth of Nazism in Germany. It will analyze its social base, means and ideology and examine the role of education as a locomotive of propaganda and social control by the Third Reich, at a time when youth were looking for an alternative to the grim situation created by the Weimar Republic. Then, having examined whether Golden Dawn is another far-right or Nazi party, it will try to shed light on the National Socialist character of the organization, despite its official turn to nationalism, in the years after 1992. To do this, it will use the organization's Declaration of Ideological Principles, exploring whether Golden Dawn's discourse on Education, as expressed through the texts addressed to youth, confirms the thirteen chapters of the Declaration.
Detection of Core-Periphery Structure in Networks Using Spectral Methods and Geodesic Paths
Creators: name: Cucuringu, Mihai
name: Rombach, Puck
name: Lee, Sang Hoon
name: Porter, Mason A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Social and Information Networks (cs.SI)
subject: Combinatorics (math.CO)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We introduce several novel and computationally efficient methods for detecting "core--periphery structure" in networks. Core--periphery structure is a type of mesoscale structure that includes densely-connected core vertices and sparsely-connected peripheral vertices. Core vertices tend to be well-connected both among themselves and to peripheral vertices, which tend not to be well-connected to other vertices. Our first method, which is based on transportation in networks, aggregates information from many geodesic paths in a network and yields a score for each vertex that reflects the likelihood that a vertex is a core vertex. Our second method is based on a low-rank approximation of a network's adjacency matrix, which can often be expressed as a tensor-product matrix. Our third approach uses the bottom eigenvector of the random-walk Laplacian to infer a coreness score and a classification into core and peripheral vertices. We also design an objective function to (1) help classify vertices into core or peripheral vertices and (2) provide a goodness-of-fit criterion for classifications into core versus peripheral vertices. To examine the performance of our methods, we apply our algorithms to both synthetically-generated networks and a variety of networks constructed from real-world data sets.
description: This article is part of EJAM's December 2016 special issue on "Network Analysis and Modelling" (available at https://www.cambridge.org/core/journals/european-journal-of-applied-mathematics/issue/journal-ejm-volume-27-issue-6/D245C89CABF55DBF573BB412F7651ADB)
Cosets of affine vertex algebras inside larger structures
Creators: name: Creutzig, Thomas
name: Linshaw, Andrew R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Representation Theory (math.RT)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: Given a finite-dimensional reductive Lie algebra $\mathfrak{g}$ equipped with a nondegenerate, invariant, symmetric bilinear form $B$, let $V^k(\mathfrak{g},B)$ denote the universal affine vertex algebra associated to $\mathfrak{g}$ and $B$ at level $k$. Let $\mathcal{A}^k$ be a vertex (super)algebra admitting a homomorphism $V^k(\mathfrak{g},B)\rightarrow \mathcal{A}^k$. Under some technical conditions on $\mathcal{A}^k$, we characterize the coset $\text{Com}(V^k(\mathfrak{g},B),\mathcal{A}^k)$ for generic values of $k$. We establish the strong finite generation of this coset in full generality in the following cases: $\mathcal{A}^k = V^k(\mathfrak{g}',B')$, $\mathcal{A}^k = V^{k-l}(\mathfrak{g}',B') \otimes \mathcal{F}$, and $\mathcal{A}^k = V^{k-l}(\mathfrak{g}',B') \otimes V^{l}(\mathfrak{g}",B")$. Here $\mathfrak{g}'$ and $\mathfrak{g}"$ are finite-dimensional Lie (super)algebras containing $\mathfrak{g}$, equipped with nondegenerate, invariant, (super)symmetric bilinear forms $B'$ and $B"$ which extend $B$, $l \in \mathbb{C}$ is fixed, and $\mathcal{F}$ is a free field algebra admitting a homomorphism $V^l(\mathfrak{g},B) \rightarrow \mathcal{F}$. Our approach is essentially constructive and leads to minimal strong finite generating sets for many interesting examples. As an application, we give a new proof of the rationality of the simple $N=2$ superconformal algebra with $c=\frac{3k}{k+2}$ for all positive integers $k$.
description: Some errors corrected, final version
Land of morning splendor
Creators: name: Griffis, W. E. (William Elliot)
Publisher: name: No Publisher Supplied
Year: 1927

description: Griffis discusses the inherent sameness of humanity through a newly shattered lens of occident vs. orient as he comes to terms with the ubiquitous role of authority and creation myths as the foundation for society. Rather than focusing on the uniqueness of these cultures through the eyes of a Westerner, Griffis uses the fundamental idea of creation as a point of comparison between Western culture and China, Japan, and Korea. Nationalism is an ideological formation that is not bound by any sort of geographic delineation. Instead, culture and society are formed through the relationship between the “Creator” and the masses. The fundamental set of morals and ideologies are a reflection of ancestry, and the adherence to these ideals acts as appreciation to said ancestors. Heavenly praise for geographic features of the homeland is unique to each country, and descriptions follow a cultural context that is not so dissimilar to Western descriptions of beautiful landscapes.
Minors and dimension
Creators: name: Walczak, Bartosz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 06A07, 05C35

description: It has been known for 30 years that posets with bounded height and with cover graphs of bounded maximum degree have bounded dimension. Recently, Streib and Trotter proved that dimension is bounded for posets with bounded height and planar cover graphs, and Joret et al. proved that dimension is bounded for posets with bounded height and with cover graphs of bounded tree-width. In this paper, it is proved that posets of bounded height whose cover graphs exclude a fixed topological minor have bounded dimension. This generalizes all the aforementioned results and verifies a conjecture of Joret et al. The proof relies on the Robertson-Seymour and Grohe-Marx graph structure theorems.
description: Updated references
XITOY HARBIY TEXNIK ATAMALARNING RUS OLIMLARI TOMONIDAN O'RGANILISHI
Creators: name: Salimova, Soxiba
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola rossiyalik olimlarning xitoylik harbiy texnika terminologiyasi bilan ilmiy aloqalarini o'rganadi. U zamonaviy Xitoy harbiy nutqidagi asosiy atamalarning etimologik ildizlarini, semantik siljishlarini va kontekstual ishlatilishini o'rganadi. Tilshunoslik tahlili va harbiy tadqiqotlar kesishishini o'rganib, ushbu maqola diplomatik munosabatlarni yaxshilash va aniq xalqaro aloqani ta'minlash uchun texnik lug'atni tushunish muhimligini ta'kidlaydi.
Additional file 1 of Split-DNAzyme cooperating primer exchange reaction for sensitive miRNA detection
Creators: name: Luo, Xuguo
name: Wu, Hongze
name: Xiong, Mingjie
name: Jiang, Liyun
name: Jiang, Zhihao
name: Gong, Minyong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Additional file 1. Table S1. Details of the sequences used in this research. Table S2. A brief comparison of the advantages and disadvantage of the method with former ones. Fig. S1. PAGE result of PAGE result of dumbbell probe assisted formation of active DNAzyme. Fig. S2. Optimization of experimental conditions. Fig. S3. Optimization of experimental conditions.
Blockchain-based identity management systems in health IoT: A systematic review
Creators: name: Alamri, Bandar
name: Crowley, Katie
name: RICHARDSON, ITA
Publisher: name: University of Limerick
Year: 2022

description: Identity and Access Management (IAM) systems are crucial for any information system, such as healthcare information systems. Health IoT (HIoT) applications are targeted by attackers due to the high-volume and sensitivity of health data. Thus, IAM systems for HIoT need to be built with high standards and based on reliable frameworks. Blockchain (BC) is an emerging technology widely used for developing decentralized IAM solutions. Although, the integration of BC in HIoT for proposing IAM solutions has gained recent attention, BC is an evolving technology and needs to be studied carefully before using it for IAM solutions in HIoT applications. A systematic literature review was conducted on the BC-based IAM systems in HIoT applications to investigate the security aspect. Twenty-four studies that satisfied the inclusion criteria and passed the quality assessment were included in this review. We studied BC-based solutions in HIoT applications to explore the IAM system architecture, security requirements and threats. We summarized the main components and technologies in typical BC-based IAM systems and the layered architecture of the BC-based IAM system in HIoT. Accordingly, the security threats and requirements were summarized. Our systematic review shows that there is a lack of a comprehensive security framework, risk assessments, and security and functional performance evaluation metrics in BC-based IAM in HIoT applications
title: Progression und Hierarchie des kolorektalen Karzinoms
Creators: name: Jung, Peter
Publisher: name: Ludwig-Maximilians-Universität München
Year: 2023
Subjects: subject: Adulte Stammzellen, kolorektales Karzinom, Wnt Signalweg, Kombinationstherapie, Chemoresistenz
subject: 600
subject: 610
subject: FOS: Medical and Health Sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Im Kontext des vorliegenden Habilitationsprojekts wurden grundlegende Erkenntnisse zu der Hierarchie, der Tumor-Mikroumgebungs-Interaktion, sowie der Chemotherapie-begleitenden Evolution des kolorektalen Karzinoms (KRK) gewonnen. So wurden die Zelloberflächen-Marker EPHB2 und PTK7 zur Aufreinigung und genetischen Charakterisierung von humanen adulten Kolonstammzellen eingesetzt und dabei interessante Parallelen zu der Organisation und dem Aufbau kolorektaler Karzinome entschlüsselt. Zudem gelang es, die so isolierten adulten (Tumor)-Stammzellen mittels eines innovativen drei-dimensionalen Kultursystems außerhalb des Organismus in Form von sogenannten (Tumor) „Organoiden“ langzeitlich und in multipotenter Form zu propagieren. Damit wurde eine unverzichtbare Plattform für die personalisierte Medizin geschaffen. Weiterhin wurde mit Hilfe des Patienten-abgeleiteten Organoidmodells der Wnt/LARGE2/α-DG/Laminin Effektor-Signalweg entdeckt und charakterisiert, welcher die Interaktion von Krebszellen mit der extrazellulären Matrix der Mikroumgebung vermittelt. Schließlich konnte die phänotypische und molekulare Anpassung von KRK Organoiden, abgeleitet von verschiedenen Patienten, an die Kombinations-Erstlinientherapie in der Kulturschale nachgestellt und ein alternativer Behandlungsansatz zur Überwindung der erworbenen Chemotoleranz erfolgreich erprobt werden. Hierbei wurde Aurora Kinase A therapeutisch angegriffen, und damit eine Inhibition der im Zuge der Chemotoleranz erhöhten Aktivität des Onkogens c-MYC sowie eine Resensitivierung der KRK Organoide gegenüber dem programmierten Zelltod (Apoptose) erreicht.