title: Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Creators: name: Christakoudi, Sofia
name: Pagoni, Panagiota
name: Ferrari, Pietro
name: Cross, Amanda J.
name: Tzoulaki, Ioanna
name: Muller, David C.
name: Weiderpass, Elisabete
name: Freisling, Heinz
name: Murphy, Neil
name: Dossus, Laure
name: Turzanski Fortner, Renee
name: Agudo, Antonio
name: Overvad, Kim
name: Perez-Cornago, Aurora
name: Key, Timothy J.
name: Brennan, Paul
name: Johansson, Mattias
name: Tjonneland, Anne
name: Halkjaer, Jytte
name: Boutron-Ruault, Marie-Christine
name: Artaud, Fanny
name: Severi, Gianluca
name: Kaaks, Rudolf
name: Schulze, Matthias B.
name: Bergmann, Manuela M.
name: Masala, Giovanna
name: Grioni, Sara
name: Simeon, Vittorio
name: Tumino, Rosario
name: Sacerdote, Carlotta
name: Skeie, Guri
name: Rylander, Charlotta
name: Borch, Kristin Benjaminsen
name: Quiros, J. Ramon
name: Rodriguez-Barranco, Miguel
name: Chirlaque, Maria-Dolores
name: Ardanaz, Eva
name: Amiano, Pilar
name: Drake, Isabel
name: Stocks, Tanja
name: Haggstrom, Christel
name: Harlid, Sophia
name: Ellingjord-Dale, Merete
name: Riboli, Elio
name: Tsilidis, Konstantinos K.
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften

description: Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (&gt;0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (&gt;0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1373