cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Loop correlations in random wire models
Creators: name: Benassi, Costanza
name: Ueltschi, Daniel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 60C05, 60K35, 82B05, 82B20, 82B26

description: We introduce a family of loop soup models on the hypercubic lattice. The models involve links on the edges, and random pairings of the link endpoints on the sites. We conjecture that loop correlations of distant points are given by Poisson-Dirichlet correlations in dimensions three and higher. We prove that, in a specific random wire model that is related to the classical XY spin system, the probability that distant sites form an even partition is given by the Poisson-Dirichlet counterpart.
description: 20 pages, 5 figures. An error in Prop. 4.1 has been corrected
Does stage of illness influence recovery-focused outcomes after psychological treatment in bipolar disorder? A systematic review protocol
Creators: name: Tremain, Hailey
name: Fletcher, Kathryn
name: Scott, Jan
name: McEnery, Carla
name: Berk, Michael
name: Murray, Greg
Publisher: name: Swinburne
Year: 2024

description: Background: There is great interest in the possibility that 'stage of illness' moderates treatment outcomes in bipolar disorder (BD). Much remains unknown about the construct of stage of illness, but there is evidence that effectiveness of psychosocial interventions may depend on factors that are plausible proxy measures of stage of illness (e.g., number of episodes). To date, reviews of this data have focused solely on clinical outcomes (particularly symptoms and relapse rates), but a range of recovery-focused outcomes (including functioning, cognitive functioning, and quality of life) have been measured in individuals with established BD. The aim of the proposed systematic review is to synthesise existing evidence for plausible proxy measures of stage of illness as moderators of recovery-focused and functional outcomes in psychosocial treatment studies of BD. Methods: The proposed review will follow PRISMA guidelines; Scopus, PsychINFO, PubMed and Web of Science will be searched for empirical studies of psychosocial interventions used for established (clinical stages 2-4) BD; and findings will be summarised in a narrative synthesis of clinical stage of illness (operationalised in proxy measures identified in existing staging models) as a moderator of recovery-focused and functional outcomes of psychosocial interventions for established bipolar disorder. Discussion: This review will contribute to the literature by expanding upon previous reviews and potentially inform the psychosocial treatment of established BD. Implications include assisting clinicians, consumers and researchers to identify and select interventions most appropriate to recovery-focused goals based on individuals' clinical status. Systematic review registration: PROSPERO CRD42016037868
Descent on elliptic surfaces and arithmetic bounds for the Mordell-Weil rank
Creators: name: Gillibert, Jean
name: Levin, Aaron
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 14D10 (Primary) 14K15, 14G25 (Secondary)

description: We introduce the use of $p$-descent techniques for elliptic surfaces over a perfect field of characteristic not $2$ or $3$. Under mild hypotheses, we obtain an upper bound for the rank of a non-constant elliptic surface. When $p=2$, this bound is an arithmetic refinement of a well-known geometric bound for the rank deduced from Igusa's inequality. This answers a question raised by Ulmer. We give some applications to rank bounds for elliptic surfaces over the rational numbers.
description: 22 pages, LaTeX. Minor improvements in the statement of Theorem 1.1. Added Theorem 1.7 and its proof. To appear in Algebra and Number Theory
Overview of RET Project
Creators: name: Lips, Karen
name: Direnzo, Graziella
Publisher: name: figshare
Year: 2014
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: This is the overview document that describes the 5 parts of our NSF-funded RET project: Panama video, NC video, background lecture, Panama lesson plan, NC lesson plan.
Cloud computing on trial: a defense of cloud computing
Creators: name: Wahlstedt, Robert
Publisher: name: figshare
Year: 2016
Subjects: subject: Computational Biology
subject: 100599 Communications Technologies not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: There has been hesitancy for people to gain the benefits of cloud computing because of a preconceived notion that data on server owned by another person is insecure. While it is true that there have been cases where law enforcement issues a subpoena to the service provider but if the information were on a server internal to the organization, then it would be also susceptible for the subpoena. However, let us not throw away the baby with the bath water. In this presentation, we look at the disadvantages of small to medium-sized businesses hosting common applications such as an email server or a customer relationship databases as compared to having the services hosted through a subscription and talk about how companies who providing hosting services now have IAAS to improve the process of their clients
On the Grothendieck-Serre Conjecture about principal bundles and its generalizations
Creators: name: Fedorov, Roman
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Let $U$ be a regular connected affine semi-local scheme over a field $k$. Let $G$ be a reductive group scheme over $U$. Assuming that $G$ has an appropriate parabolic subgroup scheme, we prove the following statement. Given an affine $k$-scheme $W$, a principal $G$-bundle over $W\times_kU$ is trivial if it is trivial over the generic fiber of the projection $W\times_kU\to U$. We also simplify the proof of the Grothendieck-Serre conjecture: let $U$ be a regular connected affine semi-local scheme over a field $k$. Let $G$ be a reductive group scheme over $U$. A principal $G$-bundle over $U$ is trivial if it is trivial over the generic point of $U$. We generalize some other related results from the simple simply-connected case to the case of arbitrary reductive group schemes.
description: Final version to be published in the Journal of Algebra and Number Theory. We slightly change the isotropy condition as well as the terminology: see Definition 1.1 of strongly locally isotropic reductive groups. We remove the assumption that U is geometrically regular in Theorem 1 (regular is enough). Other minor improvements
Data Assimilation in Large-Prandtl Rayleigh-Bénard Convection from Thermal Measurements
Creators: name: Farhat, A.
name: Glatt-Holtz, N. E.
name: Martinez, V. R.
name: McQuarrie, S. A.
name: Whitehead, J. P.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: 76E06, 62M20, 35Q35

description: This work applies a continuous data assimilation scheme---a particular framework for reconciling sparse and potentially noisy observations to a mathematical model---to Rayleigh-Bénard convection at infinite or large Prandtl numbers using only the temperature field as observables. These Prandtl numbers are applicable to the earth's mantle and to gases under high pressure. We rigorously identify conditions that guarantee synchronization between the observed system and the model, then confirm the applicability of these results via numerical simulations. Our numerical experiments show that the analytically derived conditions for synchronization are far from sharp; that is, synchronization often occurs even when the conditions of our theorems are not met. We also develop estimates on the convergence of an infinite Prandtl model to a large (but finite) Prandtl number generated set of observations. Numerical simulations in this hybrid setting indicate that the mathematically rigorous results are accurate, but of practical interest only for extremely large Prandtl numbers.
Accurate inference of crowdsourcing properties when using efficient allocation strategies
Creators: name: Hotaling, Abigail
name: Bagrow, James
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Human-Computer Interaction (cs.HC)
subject: Applications (stat.AP)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Allocation strategies improve the efficiency of crowdsourcing by decreasing the work needed to complete individual tasks accurately. However, these algorithms introduce bias by preferentially allocating workers onto easy tasks, leading to sets of completed tasks that are no longer representative of all tasks. This bias challenges inference of problem-wide properties such as typical task difficulty or crowd properties such as worker completion times, important information that goes beyond the crowd responses themselves. Here we study inference about problem properties when using an allocation algorithm to improve crowd efficiency. We introduce Decision-Explicit Probability Sampling (DEPS), a novel method to perform inference of problem properties while accounting for the potential bias introduced by an allocation strategy. Experiments on real and synthetic crowdsourcing data show that DEPS outperforms baseline inference methods while still leveraging the efficiency gains of the allocation method. The ability to perform accurate inference of general properties when using non-representative data allows crowdsourcers to extract more knowledge out of a given crowdsourced dataset.
description: 17 pages, 6 figures, 1 table
Formal groups and lifts of the field of norms
Creators: name: Poyeton, Léo
Publisher: name: arXiv
Year: 2019
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $K$ be a finite extension of $\mathbf{Q}_p$. The field of norms of a strictly APF extension $K_\infty/K$ is a local field of characteristic $p$ equipped with an action of $\mathrm{Gal}(K_\infty/K)$. When can we lift this action to characteristic zero, along with a compatible Frobenius map ? In this article, we explain what we mean by lifting the field of norms, explain its relevance to the theory of $(φ,Γ)$-modules, and show that under a certain assumption on the type of lift, such an extension is generated by the torsion points of a relative Lubin-Tate group and that the power series giving the lift of the action of the Galois group of $K_\infty/K$ are twists of semi-conjugates of endomorphisms of the same relative Lubin-Tate group.
Noncommutative Knörrer's periodicity theorem and noncommutative quadric hypersurfaces
Creators: name: Mori, Izuru
name: Ueyama, Kenta
Publisher: name: arXiv
Year: 2019
Subjects: subject: Rings and Algebras (math.RA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: Noncommutative hypersurfaces, in particular, noncommutative quadric hypersurfaces are major objects of study in noncommutative algebraic geometry. In the commutative case, Knörrer's periodicity theorem is a powerful tool to study Cohen-Macaulay representation theory since it reduces the number of variables in computing the stable category $\underline{\operatorname{CM}}(A)$ of maximal Cohen-Macaulay modules over a hypersurface $A$. In this paper, we prove a noncommutative graded version of Knörrer's periodicity theorem. Moreover, we prove another way to reduce the number of variables in computing the stable category ${\underline{\operatorname{CM}}}^{\mathbb Z}(A)$ of graded maximal Cohen-Macaulay modules if $A$ is a noncommutative quadric hypersurface. Under high rank property defined in this paper, we also show that computing ${\underline{\operatorname{CM}}}^{\mathbb Z}(A)$ over a noncommutative smooth quadric hypersurface $A$ in up to six variables can be reduced to one or two variables cases. In addition, we give a complete classification of ${\underline{\operatorname{CM}}}^{\mathbb Z}(A)$ over a smooth quadric hypersurface $A$ in a skew $\mathbb P^{n-1}$, where $n \leq 6$, without high rank property using graphical methods.
description: 31 pages
Spatio-Temporal Representation with Deep Neural Recurrent Network in MIMO CSI Feedback
Creators: name: Li, Xiangyi
name: Wu, Huaming
Publisher: name: arXiv
Year: 2019
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: In multiple-input multiple-output (MIMO) systems, it is crucial of utilizing the available channel state information (CSI) at the transmitter for precoding to improve the performance of frequency division duplex (FDD) networks. One of the mainchallenges is to compress a large amount of CSI in CSI feedback transmission in massive MIMO systems. In this paper, we propose a deep learning (DL)-based approach that uses a deep recurrent neural network (RNN) to learn temporal correlation and adopts depthwise separable convolution to shrink the model. The feature extraction module is also elaborately devised by studyingdecoupled spatio-temporal feature representations in different structures. Experimental results demonstrate that the proposed approach outperforms existing DL-based methods in terms of recovery quality and accuracy, which can also achieve remarkable robustness at low compression ratio (CR).
description: 5pages, 6figures, 14conference
Relaxation of the Cahn-Hilliard equation with singular single-well potential and degenerate mobility
Creators: name: Perthame, Benoît
name: Poulain, Alexandre
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35B40, 35G20, 35Q92, 92C10

description: The degenerate Cahn-Hilliard equation is a standard model to describe living tissues. It takes into account cell populations undergoing short-range attraction and long-range repulsion effects. In this framework, we consider the usual Cahn-Hilliard equation with a singular single-well potential and degenerate mobility. These degeneracy and singularity induce numerous difficulties, in particular for its numerical simulation. To overcome these issues, we propose a relaxation system formed of two second order equations which can be solved with standard packages. This system is endowed with an energy and an entropy structure compatible with the limiting equation. Here, we study the theoretical properties of this system; global existence and convergence of the relaxed system to the degenerate Cahn-Hilliard equation. We also study the long-time asymptotics which interest relies on the numerous possible steady states with given mass.
title: édition 2015
Publisher: name: EHESS
Year: 2015

description: La justice sous le regard des sciences sociales 9h-9h15 : Ouverture par M. Pierre-Cyrille Hautcoeur, Président de l’EHESS   9h15-9h30 : Allocution de Mme Christiane Taubira, Garde des Sceaux, Ministre de la Justice   9h30-9h45 :"La dangerosité du savoir" par Bernard Harcourt, professeur de droit à l’université de Columbia, directeur d’études à l’EHESS.   9h45-11h15 : Table ronde 1. Les voies judiciaires pour la victime : action collective et action individuelle Animatrice : Sandrine Zientara, magistrate, directrice de la Mission de recherche Droit et Justice “Les débats doctrinaux autour de la place de la victime au procès pénal” par Nicolas Dodier, sociologue, directeur d’études à l’EHESS, LIER-IMM, directeur de recherche INSERM. “De la réparation individuelle à l’élaboration d’une cause collective. L’engagement judiciaire des victimes d
Stereotype approximation property for the algebras $C(M)$ of continuous functions on metric spaces
Creators: name: Akbarov, Sergei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: In his previous works the author introduced the notion of the stereotype approximation property as an analog of the classical approximation property transferred to the category ${\tt Ste}$ of stereotype spaces. It is known, that the study of this property is much more difficult than in the classical theory, since the spaces of operators in the category ${\tt Ste}$ are defined in a more complicated way. In this note, it is proved that the algebra $C(M)$ of continuous functions on an arbitrary complete (not necessarily locally compact) metric space $M$ has the stereotype approximation property.
description: 5 pages
Radiation from Global Topological Strings using Adaptive Mesh Refinement: Methodology and Massless Modes
Creators: name: Drew, Amelia
name: Shellard, E. P. S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We implement adaptive mesh refinement (AMR) simulations of global topological strings using the public numerical relativity code, GRChombo. We perform a quantitative investigation of the dynamics of single sinusoidally displaced string configurations, studying a wide range of string energy densities $μ\propto \lnλ$, defined by the string width parameter $λ$ over two orders of magnitude. We investigate the resulting massless (Goldstone boson or axion) radiation signals, using quantitative diagnostic tools to determine the eigenmode decomposition. Given analytic radiation predictions, we compare the oscillating string trajectory with a backreaction model accounting for radiation energy losses, finding excellent agreement. We establish that backreaction decay is accurately characterised by the inverse square of the amplitude being proportional to the inverse tension $μ$ for $3\lesssim λ\lesssim 100$. We conclude that analytic radiation modelling in the thin-string (Nambu-Goto) limit provides the appropriate cosmological limit for global strings. We contextualise these results with respect to axions and gravitational waves produced by cosmic string networks.
description: 25 pages, 28 figures, version published in PRD including convergence tests
JWST-TST DREAMS: A Super-Solar Metallicity in WASP-17b's Dayside Atmosphere from NIRISS SOSS Eclipse Spectroscopy - dataset
Creators: name: Gressier, Amélie
Publisher: name: Zenodo
Year: 2024

description: This repository is for the paper JWST-TST DREAMS: A Super-Solar Metallicity in WASP-17b's Dayside Atmosphere from NIRISS SOSS Eclipse Spectroscopy by Gressier et al. This repository contains emission spectra for WASP-17b obtained using three reduction pipelines: transitspectroscopy, supremespoon, and ahsoka. Each spectrum includes measurements of planetary flux relative to stellar flux Fp/Fstar. The transitspectroscopy reduction offers two versions: one with only positive eclipse depths and another using priors that allow negative eclipse depths, resulting in negative Fp/Fstar. Additionally, we provide planetary brightness temperatures with associated confidence intervals derived from the transitspectroscopy negative-depth reduction. This dataset enables a comparative analysis of reduction methods, assessing the robustness of brightness temperature estimates for WASP-17b's atmosphere.
Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity
Creators: name: Verso, Francesca Lo
name: Carnio, Silvia
name: Vainshtein, Anna
name: Sandri, Marco
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Meta Science
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Physiology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Physical activity has been recently documented to play a fundamental physiological role in the regulation of autophagy in several tissues. It has also been reported that autophagy is required for exercise itself and for training-induced adaptations in glucose homeostasis. These autophagy-mediated metabolic improvements are thought to be largely dependent on the activation of the metabolic sensor PRKAA1/AMPK. However, it is unknown whether these important benefits stem from systemic adaptations or are due solely to alterations in skeletal muscle metabolism. To address this we utilized inducible, muscle-specific, atg7 knockout mice that we have recently generated. Our findings indicate that acute inhibition of autophagy in skeletal muscle just prior to exercise does not have an impact on physical performance, PRKAA1 activation, or glucose homeostasis. However, we reveal that autophagy is critical for the preservation of mitochondrial function during damaging muscle contraction. This effect appears to be gender specific affecting primarily females. We also establish that basal oxidative stress plays a crucial role in mitochondrial maintenance during normal physical activity. Therefore, autophagy is an adaptive response to exercise that ensures effective mitochondrial quality control during damaging physical activity.
Tracking the circulation routes of fresh coins in Bitcoin: A way of identifying coin miners with transaction network structural properties
Creators: name: Lin, Zeng-Xian
name: Liu, Xiao Fan
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Finance (q-fin.GN)
subject: Cryptography and Security (cs.CR)
subject: Information Retrieval (cs.IR)
subject: General Economics (econ.GN)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: Bitcoin draws the highest degree of attention among cryptocurrencies, while coin mining is one of the most important fashion of profiting in the Bitcoin ecosystem. This paper constructs fresh coin circulation networks by tracking the fresh coin transfer routes with transaction referencing in Bitcoin blockchain. This paper proposes a heuristic algorithm to identifying coin miners by comparing coin circulation networks from different mining pools and thereby inferring the common profit distribution schemes of Bitcoin mining pools. Furthermore, this paper characterizes the increasing trend of Bitcoin miner numbers during recent years.
description: an English version of the journal article published in Chinese
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy
Creators: name: Sungwoo Park
name: Seon-Guk Choi
name: Yoo, Seung-Min
name: Son, Jin H
name: Yong-Keun Jung
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: CHDH (choline dehydrogenase) is an enzyme catalyzing the dehydrogenation of choline to betaine aldehyde in mitochondria. Apart from this well-known activity, we report here a pivotal role of CHDH in mitophagy. Knockdown of CHDH expression impairs CCCP-induced mitophagy and PARK2/parkin-mediated clearance of mitochondria in mammalian cells, including HeLa cells and SN4741 dopaminergic neuronal cells. Conversely, overexpression of CHDH accelerates PARK2-mediated mitophagy. CHDH is found on both the outer and inner membranes of mitochondria in resting cells. Interestingly, upon induction of mitophagy, CHDH accumulates on the outer membrane in a mitochondrial potential-dependent manner. We found that CHDH is not a substrate of PARK2 but interacts with SQSTM1 independently of PARK2 to recruit SQSTM1 into depolarized mitochondria. The FB1 domain of CHDH is exposed to the cytosol and is required for the interaction with SQSTM1, and overexpression of the FB1 domain only in cytosol reduces CCCP-induced mitochondrial degradation via competitive interaction with SQSTM1. In addition, CHDH, but not the CHDH FB1 deletion mutant, forms a ternary protein complex with SQSTM1 and MAP1LC3 (LC3), leading to loading of LC3 onto the damaged mitochondria via SQSTM1. Further, CHDH is crucial to the mitophagy induced by MPP+ in SN4741 cells. Overall, our results suggest that CHDH is required for PARK2-mediated mitophagy for the recruitment of SQSTM1 and LC3 onto the mitochondria for cargo recognition.
Essential Finite Generation of Valuation Rings in Characteristic Zero Algebraic Function Fields
Creators: name: Cutkosky, Steven Dale
Publisher: name: arXiv
Year: 2019
Subjects: subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 13A18, 14E15

description: Let $K$ be a characteristic zero algebraic function field with a valuation $ν$. Let $L$ be a finite extension of $K$ and $ω$ be an extension of $ν$ to $L$. We establish that the valuation ring $V_ω$ of $ω$ is essentially finitely generated over the valuation ring $V_ν$ of $ν$ if and only if the initial index $ε(ω|ν)$ is equal to the ramification index $e(ω|ν)$ of the extension. This gives a positive answer, for characteristic zero algebraic function fields, to a question posed by Hagen Knaf.
description: 16 pages
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression
Creators: name: Giegerich, Annika Klara
name: Kuchler, Laura
name: Sha, Lisa Katharina
name: Knape, Tilo
name: Heide, Heinrich
name: Wittig, Ilka
name: Behrends, Christian
name: Brüne, Bernhard
name: Knethen, Andreas Von
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the first phase of sepsis. Therefore, counteracting excessive innate immunity by autophagy is important to contribute to the termination of inflammation. However, the exact molecular details of this interplay are only poorly understood. Here, we show that PELI3/Pellino3 (pellino E3 ubiquitin protein ligase family member 3), which is an E3 ubiquitin ligase and scaffold protein in TLR4-signaling, is impacted by autophagy in macrophages (MΦ) after LPS stimulation. We noticed an attenuated mRNA expression of proinflammatory Il1b (interleukin 1, β) in Peli3 knockdown murine MΦ in response to LPS treatment. The autophagy adaptor protein SQSTM1/p62 (sequestosome 1) emerged as a potential PELI3 binding partner in TLR4-signaling. siRNA targeting Sqstm1 and Atg7 (autophagy related 7), pharmacological inhibition of autophagy by wortmannin as well as blocking the lysosomal vacuolar-type H+-ATPase by bafilomycin A1 augmented PELI3 protein levels, while inhibition of the proteasome had no effect. Consistently, treatment to induce autophagy by MTOR (mechanistic target of rapamycin (serine/threonine kinase)) inhibition or starvation enhanced PELI3 degradation and reduced proinflammatory Il1b expression. PELI3 was found to be ubiquitinated upon LPS stimulation and point mutation of PELI3-lysine residue 316 (Lys316Arg) attenuated Torin2-dependent degradation of PELI3. Immunofluorescence analysis revealed that PELI3 colocalized with the typical autophagy markers MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) and LAMP2 (lysosomal-associated membrane protein 2). Our observations suggest that autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis.
Detectability of Electromagnetic counterparts from Neutron Star mergers: prompt emission vs afterglow
Creators: name: Mohan, S
name: Saleem, M
name: Resmi, L
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Electromagnetic observations of the first binary Neutron Star (BNS) merger GW170817 has established that relativistic jets can be successfully launched in BNS mergers. Typically, such jets produce emission in two phases: $γ$-ray prompt emission and multi-wavelength afterglow. Due to relativistic de-boosting, the detectability of both these counterparts is dependent on the angle ($θ_v$) between the observer's line of sight and the jet axis. We compare the detectability of prompt and afterglow emission from off-axis jets, assuming standard detector thresholds. We find that for top-hat jets, afterglow is a more potential counterpart than the prompt emission even with unfavorable afterglow parameters. For structured jets with a Gaussian profile, prompt emission is more promising than the afterglows at extreme viewing angles, under the assumption that the energy emitted in the prompt phase equals the kinetic energy of the outflow. Assuming a Gaussian jet profile, we forecast the population of $γ$-ray detections and find that extreme viewing angle events like GRB170817A will be rare. In our simulated sample, the observed isotropic equivalent energy in $γ$-rays is moderately correlated with the viewing angle, such that a low $E_{\rm iso, γ}$ is almost always associated with a high off-axis viewing angle.
description: 9 pages, 10 figures, submitted to MNRAS
title: T4 - Usines logicielles et sciences reproductibles
Publisher: name: JDEV
Year: 2020

description: Il s’agit d'un axe coeur de métier du développement visant à favoriser   la science reproductible par le numérique. Pour ce faire, la mise en   place d'usines logicielles et d'outils de production de code pour   supporter les bonnes pratiques de génie logiciel et les besoins des   laboratoires seront étudiées. Nous nous intéresserons à l'opportunité   d'intégrer à ces usines logicielles des référentiels de code, des   contextes de déploiement et d'exécution. L'accessibilité, la   réutilisation et la sécurité seront notre préoccupation. En quelques   sortes, les aspects FAIR pour les ressources calculé Plus d'informations
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression
Creators: name: Giegerich, Annika Klara
name: Kuchler, Laura
name: Sha, Lisa Katharina
name: Knape, Tilo
name: Heide, Heinrich
name: Wittig, Ilka
name: Behrends, Christian
name: Brüne, Bernhard
name: Knethen, Andreas Von
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the first phase of sepsis. Therefore, counteracting excessive innate immunity by autophagy is important to contribute to the termination of inflammation. However, the exact molecular details of this interplay are only poorly understood. Here, we show that PELI3/Pellino3 (pellino E3 ubiquitin protein ligase family member 3), which is an E3 ubiquitin ligase and scaffold protein in TLR4-signaling, is impacted by autophagy in macrophages (MΦ) after LPS stimulation. We noticed an attenuated mRNA expression of proinflammatory Il1b (interleukin 1, β) in Peli3 knockdown murine MΦ in response to LPS treatment. The autophagy adaptor protein SQSTM1/p62 (sequestosome 1) emerged as a potential PELI3 binding partner in TLR4-signaling. siRNA targeting Sqstm1 and Atg7 (autophagy related 7), pharmacological inhibition of autophagy by wortmannin as well as blocking the lysosomal vacuolar-type H+-ATPase by bafilomycin A1 augmented PELI3 protein levels, while inhibition of the proteasome had no effect. Consistently, treatment to induce autophagy by MTOR (mechanistic target of rapamycin (serine/threonine kinase)) inhibition or starvation enhanced PELI3 degradation and reduced proinflammatory Il1b expression. PELI3 was found to be ubiquitinated upon LPS stimulation and point mutation of PELI3-lysine residue 316 (Lys316Arg) attenuated Torin2-dependent degradation of PELI3. Immunofluorescence analysis revealed that PELI3 colocalized with the typical autophagy markers MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) and LAMP2 (lysosomal-associated membrane protein 2). Our observations suggest that autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis.
Classification and Liouville-type theorems for semilinear elliptic equations in unbounded domains
Creators: name: Dupaigne, Louis
name: Farina, ALberto
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We classify stable and finite Morse index solutions to general semilinear elliptic equations posed in Euclidean space of dimension at most 10, or in some unbounded domains.
Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity
Creators: name: Verso, Francesca Lo
name: Carnio, Silvia
name: Vainshtein, Anna
name: Sandri, Marco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Meta Science
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Physiology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Physical activity has been recently documented to play a fundamental physiological role in the regulation of autophagy in several tissues. It has also been reported that autophagy is required for exercise itself and for training-induced adaptations in glucose homeostasis. These autophagy-mediated metabolic improvements are thought to be largely dependent on the activation of the metabolic sensor PRKAA1/AMPK. However, it is unknown whether these important benefits stem from systemic adaptations or are due solely to alterations in skeletal muscle metabolism. To address this we utilized inducible, muscle-specific, atg7 knockout mice that we have recently generated. Our findings indicate that acute inhibition of autophagy in skeletal muscle just prior to exercise does not have an impact on physical performance, PRKAA1 activation, or glucose homeostasis. However, we reveal that autophagy is critical for the preservation of mitochondrial function during damaging muscle contraction. This effect appears to be gender specific affecting primarily females. We also establish that basal oxidative stress plays a crucial role in mitochondrial maintenance during normal physical activity. Therefore, autophagy is an adaptive response to exercise that ensures effective mitochondrial quality control during damaging physical activity.
Distinguished Varieties Through the Berger--Coburn--Lebow Theorem
Creators: name: Bhattacharyya, Tirthankar
name: Kumar, Poornendu
name: Sau, Haripada
Publisher: name: arXiv
Year: 2020
Subjects: subject: Functional Analysis (math.FA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 47A13

description: A distinguished algebraic variety in $\mathbb{C}^2$ has been the focus of much research in recent years because of good reasons. This note gives a different perspective. (1) We find a new characterization of an algebraic variety $\mathcal W$ which is distinguished with respect to the bidisc. It is in terms of the joint spectrum of a pair of commuting linear matrix pencils. (2) There is a characterization known of $\mathbb{D}^2\cap\mathcal{W}$ due to a seminal work of Agler and McCarthy. We show that Agler--McCarthy characterization can be obtained from the new one and vice versa. (3) En route, we develop a new realization formula for operator-valued contractive analytic functions on the unit disc. (4) There is a one-to-one correspondence between operator valued contractive holomorphic functions and {\em canonical model triples}. This pertains to the new realization formula mentioned above. (5) Pal and Shalit gave a characterization of an algebraic variety, which is distinguished with respect to the symmetrized bidisc, in terms of a matrix of numerical radius no larger than $1$. We refine their result by making the class of matrices strictly smaller. (6) In a generalization in the direction of more than two variables, we characterize all one-dimensional algebraic varieties which are distinguished with respect to the polydisc. At the root of our work is the Berger--Coburn--Lebow theorem characterizing a commuting tuple of isometries.
description: 25 page. To appear in Analysis and PDE
Differentially Quantized Gradient Methods
Creators: name: Lin, Chung-Yi
name: Kostina, Victoria
name: Hassibi, Babak
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Information Theory (cs.IT)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Consider the following distributed optimization scenario. A worker has access to training data that it uses to compute the gradients while a server decides when to stop iterative computation based on its target accuracy or delay constraints. The server receives all its information about the problem instance from the worker via a rate-limited noiseless communication channel. We introduce the principle we call Differential Quantization (DQ) that prescribes compensating the past quantization errors to direct the descent trajectory of a quantized algorithm towards that of its unquantized counterpart. Assuming that the objective function is smooth and strongly convex, we prove that Differentially Quantized Gradient Descent (DQ-GD) attains a linear contraction factor of $\max\{σ_{\mathrm{GD}}, ρ_n 2^{-R}\}$, where $σ_{\mathrm{GD}}$ is the contraction factor of unquantized gradient descent (GD), $ρ_n \geq 1$ is the covering efficiency of the quantizer, and $R$ is the bitrate per problem dimension $n$. Thus at any $R\geq\log_2 ρ_n /σ_{\mathrm{GD}}$ bits, the contraction factor of DQ-GD is the same as that of unquantized GD, i.e., there is no loss due to quantization. We show that no algorithm within a certain class can converge faster than $\max\{σ_{\mathrm{GD}}, 2^{-R}\}$. Since quantizers exist with $ρ_n \to 1$ as $n \to \infty$ (Rogers, 1963), this means that DQ-GD is asymptotically optimal. The principle of differential quantization continues to apply to gradient methods with momentum such as Nesterov's accelerated gradient descent, and Polyak's heavy ball method. For these algorithms as well, if the rate is above a certain threshold, there is no loss in contraction factor obtained by the differentially quantized algorithm compared to its unquantized counterpart. Experimental results on least-squares problems validate our theoretical analysis.
GW170817 and GW190425 as Hybrid Stars of Dark and Nuclear Matters
Creators: name: Zhang, Kilar
name: Huang, Guo-Zhang
name: Tsao, Jie-Shiun
name: Lin, Feng-Li
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose three scenarios for compact hybrid stars composed of nuclear and dark matter. These hybrid stars could provide alternative interpretations to the LIGO/Virgo events GW170817 and GW190425. To demonstrate our proposal, we solve the Tolman-Oppenheimer-Volkoff configurations of hybrid stars by using the SLy4, APR4, and SKb equations of state (EoS) for nuclear matter, and an EoS for a bosonic self interacting dark matter (SIDM) proposed by Colpi et al \cite{Colpi:1986ye}. We then obtain their mass-radius and tidal Love number (TLN)-mass relations, and further examine the possible saddle instability of these compact objects by the generalized Bardeen-Thorne-Meltzer (BTM) criteria. Our results show that the hybrid star scenarios are able to explain GW170817 and GW190425. Some hybrid stars can have compact neutron or mixed cores around 10 km while possessing thick dark matter shells, thus they can be more massive than the maximum mass of the typical neutron stars but are electromagnetically detected with about the same size of neutron stars. Reversely, we also infer the dark matter model from the parameter estimation of GW190425. Our proposed hybrid stars can be further tested by the coming LIGO/Virgo O3 events.
description: 16 pages, 17 figures, 1 table; v2: major revision, nuclear matter EoS SLy4 case included, figures and references added; v3: minor revision, figures replaced, references added; v4: published version, accepted by EPJC
title: Défaire l’Empire
Publisher: name: Site Pouchet du CNRS
Year: 2015

description: La pensée postcoloniale, dans son éclatement épistémique, a ceci d’unique qu’elle est une critique du décentrement. En somme elle propose de prendre le contre-pied d’un récit historique qui a fait le choix d’adopter une interprétation téléologique, en mettant de côté les ruses du pouvoir ou la capacité de son rapport à se reconfigurer malgré les prétentions du Progrès. Une des manières d’endosser et d’habiter la postcolonialité est de penser à partir justement de la marge. Il résulte de ce travail, de nouvelles perspectives heuristiques qui exhument et mettent en exergue des récits, y compris ceux des dominants, et de les relire à l’aulne d’une perspective et d’un positionnement infâme.     La journée d’études posera dans un premier temps la question de ce que peut être un objet postcolonial, sa spécificité et/ou son lien avec les traditi
A Szemerédi-type theorem for subsets of the unit cube
Creators: name: Durcik, Polona
name: Kovač, Vjekoslav
Publisher: name: arXiv
Year: 2020
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05D10, 42B20, 11B30

description: We investigate gaps of $n$-term arithmetic progressions $x, x+y, \ldots, x+(n-1)y$ inside a positive measure subset $A$ of the unit cube $[0,1]^d$. If lengths of their gaps $y$ are evaluated in the $\ell^p$-norm for any $p$ other than $1, 2, \ldots, n-1$, and $\infty$, and if the dimension $d$ is large enough, then we show that the numbers $\|y\|_{\ell^p}$ attain all values from an interval, the length of which depends only on $n$, $p$, $d$, and the measure of $A$. Known counterexamples prevent generalizations of this result to the remaining values of the exponent $p$. We also give an explicit bound for the length of the aforementioned interval. The proof makes the bound depend on the currently available bounds in Szemerédi's theorem on the integers, which are used as a black box. A key ingredient of the proof are power-type cancellation estimates for operators resembling the multilinear Hilbert transforms. As a byproduct of the approach we obtain a quantitative improvement of the corresponding (previously known) result for side lengths of $n$-dimensional cubes with vertices lying in a positive measure subset of $([0,1]^2)^n$.
description: 40 pages; v2: minor changes following referee's report
An asymptotic expansion of two-bubble wave maps
Creators: name: Jendrej, Jacek
name: Lawrie, Andrew
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: This is the first part of a two-paper series that establishes the uniqueness and regularity of a threshold energy wave map that does not scatter in both time directions. Consider the two-sphere valued equivariant energy critical wave maps equation on 1+2 dimensional Minkowski space, with equivariance class k>3. It is known that every topologically trivial wave map with energy less than twice that of the unique k-equivariant harmonic map Q scatters in both time directions. We study maps with precisely the threshold energy, i.e., twice the energy of Q. In this paper, we give a refined construction of a wave map with threshold energy that converges to a superposition of two harmonic maps (bubbles), asymptotically decoupling in scale. We show that this two-bubble solution possesses H^2 regularity. We give a precise dynamical description of the modulation parameters as well as an expansion of the map into profiles. In the next paper in the series, we show that this solution is unique (up to the natural invariances of the equation) relying crucially on the detailed properties of the solution constructed here. Combined with our earlier work, we can now give an exact description of every threshold wave map.
description: 74 pages; first paper of a two-paper series
Quantum Geometric Confinement and Dynamical Transmission in Grushin Cylinder
Creators: name: Gallone, Matteo
name: Michelangeli, Alessandro
name: Pozzoli, Eugenio
Publisher: name: arXiv
Year: 2020
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We classify the self-adjoint realisations of the Laplace-Beltrami operator minimally defined on an infinite cylinder equipped with an incomplete Riemannian metric of Grushin type, in the class of metrics yielding an infinite deficiency index. Such realisations are naturally interpreted as Hamiltonians governing the geometric confinement of a Schrödinger quantum particle away from the singularity, or the dynamical transmission across the singularity. In particular, we characterise all physically meaningful extensions qualified by explicit local boundary conditions at the singularity. Within our general classification we retrieve those distinguished extensions previously identified in the recent literature, namely the most confining and the most transmitting one.
description: 70 pages
H-principle for the 2D incompressible porous media equation with viscosity jump
Creators: name: Mengual, Francisco
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this work we extend the results in [6,32] on the 2D IPM system with constant viscosity (Atwood number $A_μ=0$) to the case of viscosity jump ($|A_μ|<1$). We prove a h-principle whereby (infinitely many) weak solutions in $C_tL_{w^*}^{\infty}$ are recovered via convex integration whenever a subsolution is provided. As a first example, non-trivial weak solutions with compact support in time are obtained. Secondly, we construct mixing solutions to the unstable Muskat problem with initial flat interface. As a byproduct, we check that the connection, established by Székelyhidi for $A_μ=0$, between the subsolution and the Lagrangian relaxed solution of Otto, holds for $|A_μ|<1$ too. For different viscosities, we show how a pinch singularity in the relaxation prevents the two fluids from mixing wherever there is neither Rayleigh-Taylor nor vorticity at the interface.
description: 38 pages
Drag force on a moving heavy quark with deformed string configuration
Creators: name: Tahery, Sara
name: Chen, Xurong
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: To study drag force on a moving heavy quark through a plasma, we use a deformed AdS space-time, in which deformation parameter $c$ describes non-conformality in AdS/QCD. In this case the quark is mapped to a probe string in the AdS space. Considering probable contribution of deformation parameter in the probe string, we apply a general form of c-dependent string ansatz in the drag force computation. Then we find the acceptable value of this parameter as it satisfies QCD calculations. Using this result, we also discuss diffusion constant which is in agreement with phenomenological result for non-relativistic limit. Also we show that while in absence of deformation parameter, probe string is a strictly increasing function of radial coordinate, the c-dependent probe string has a maximum value versus $z$.
description: 18 pages, 4 figures