cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Introducing extended consultations for patients with severe mental illness in general practice: Results from the SOFIA feasibility study
Creators: name: Jønsson, A. B. R.
name: Martiny, F. H. J.
name: Søndergaard, M. K.
name: Brodersen, J. B.
name: Due, T. D.
name: Nielsen, M. H.
name: Bakkedal, C.
name: Bardram, J. E.
name: Bissenbakker, K.
name: Christensen, I.
name: Doherty, K.
name: Kjellberg, P.
name: Mercer, S. W.
name: Reventlow, S.
name: Rozing, M. P.
name: Møller, A.
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1.
sj-pdf-1-msj-10.1177_13524585211064121 – Supplemental material for The contribute of cerebrospinal fluid free light-chain assay in the diagnosis of multiple sclerosis and other neurological diseases in an Italian multicenter study
Creators: name: Bernardi, Gaetano
name: Biagioli, Tiziana
name: Malpassi, Paola
name: De Michele, Teresa
name: Vecchio, Domizia
name: Repice, Anna Maria
name: Lugaresi, Alessandra
name: Mirabella, Massimiliano
name: Torri Clerici, Valentina
name: Crespi, Ilaria
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-msj-10.1177_13524585211064121 for The contribute of cerebrospinal fluid free light-chain assay in the diagnosis of multiple sclerosis and other neurological diseases in an Italian multicenter study by Gaetano Bernardi, Tiziana Biagioli, Paola Malpassi, Teresa De Michele, Domizia Vecchio, Anna Maria Repice, Alessandra Lugaresi, Massimiliano Mirabella, Valentina Torri Clerici and Ilaria Crespi in Multiple Sclerosis Journal
title: Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin-releasing hormone stimulation test in horses and ponies
Creators: name: Drożdżewska, Karolina
name: Winter, Judith
name: Barton, Ann Kristin
name: Merle, Roswitha
name: Gehlen, Heidrun
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: ACTH
subject: adrenocorticotropin
subject: endocrine
subject: horse
subject: PPID
subject: TRH
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: Background The basal (bACTH) and post-thyrotropin-releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH. Objectives To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH. Study design Prospective crossover. Methods Sixty-one animals were divided into groups: healthy, PPID, treated-PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid-November to mid-July) after different feedings: fasting, hay, hay + grain. Friedman's test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors. Results The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9–49.5 pg/mL) and highest in PPID-group (58.9 pg/mL, CI 39.7–78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2–510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7–696.2 pg/mL) and treated-PPID group (683.1 pg/mL, CI 585.9–780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3–1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5–869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8–452.5 pg/mL). The size of effect for those variables was >0.5. Main limitations Small number of animals, subsequent bACTH measurements were significantly lower in each horse. Conclusions There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results.
sj-pdf-1-pqx-10.1177_10986111211037592 - Supplemental material for Detectives’ Descriptions of Their Responses to Sexual Assault Cases and Victims: Assessing the Overlap Between Rape Myths and Focal Concerns
Creators: name: George, Suzanne St.
name: Verhagan, Megan
name: Spohn, Cassia
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, sj-pdf-1-pqx-10.1177_10986111211037592 for Detectives’ Descriptions of Their Responses to Sexual Assault Cases and Victims: Assessing the Overlap Between Rape Myths and Focal Concerns by Suzanne St. George, Megan Verhagan and Cassia Spohn in Police Quarterly
Additional file 2 of Introducing extended consultations for patients with severe mental illness in general practice: Results from the SOFIA feasibility study
Creators: name: Jønsson, A. B. R.
name: Martiny, F. H. J.
name: Søndergaard, M. K.
name: Brodersen, J. B.
name: Due, T. D.
name: Nielsen, M. H.
name: Bakkedal, C.
name: Bardram, J. E.
name: Bissenbakker, K.
name: Christensen, I.
name: Doherty, K.
name: Kjellberg, P.
name: Mercer, S. W.
name: Reventlow, S.
name: Rozing, M. P.
name: Møller, A.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 2. Interview and observation guide.
sj-docx-1-rop-10.1177_0734371X211065348 – Supplemental material for “I Expected More From You”: The Effect of Expectation-Disconfirmation on Employees’ Satisfaction With Supervisory Support
Creators: name: Penning de Vries, Julia
name: Knies, Eva
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-docx-1-rop-10.1177_0734371X211065348 for “I Expected More From You”: The Effect of Expectation-Disconfirmation on Employees’ Satisfaction With Supervisory Support by Julia Penning de Vries and Eva Knies in Review of Public Personnel Administration
title: Risk and protective factors, stressors, and symptoms of adjustment disorder during the COVID-19 pandemic – First results of the ESTSS COVID-19 pan-European ADJUST study
Creators: name: Lotzin, Annett
name: Krause, Linda
name: Acquarini, Elena
name: Ajdukovic, Dean
name: Ardino, Vittoria
name: Arnberg, Filip
name: Böttche, Maria
name: Bragesjö, Maria
name: Dragan, Małgorzata
name: Figueiredo-Braga, Margarida
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: COVID-19
subject: pandemic
subject: disaster
subject: coronavirus
subject: adjustment disorder
subject: mental health
subject: stressors
subject: stress-related disorders
classificationCode: 150
subject: Psychologie

description: Background The COVID-19 pandemic exposes individuals to multiple stressors, such as quarantine, physical distancing, job loss, risk of infection, and loss of loved ones. Such a complex array of stressors potentially lead to symptoms of adjustment disorder. Objective This cross-sectional exploratory study examined relationships between risk and protective factors, stressors, and symptoms of adjustment disorder during the first year of the COVID-19 pandemic. Methods Data from the first wave of the European Society of Traumatic Stress Studies (ESTSS) longitudinal ADJUST Study were used. N = 15,563 participants aged 18 years and above were recruited in eleven countries (Austria, Croatia, Georgia, Germany, Greece, Italy, Lithuania, the Netherlands, Poland, Portugal, and Sweden) from June to November 2020. Associations between risk and protective factors (e.g. gender, diagnosis of a mental health disorder), stressors (e.g. fear of infection, restricted face-to-face contact), and symptoms of adjustment disorder (ADNM-8) were examined using multivariate linear regression. Results The prevalence of self-reported probable adjustment disorder was 18.2%. Risk factors associated with higher levels of symptoms of adjustment disorder were female gender, older age, being at risk for severe COVID-19 illness, poorer general health status, current or previous trauma exposure, a current or previous mental health disorder, and longer exposure to COVID-19 news. Protective factors related to lower levels of symptoms of adjustment disorder were higher income, being retired, and having more face-to-face contact with loved ones or friends. Pandemic-related stressors associated with higher levels of symptoms of adjustment disorder included fear of infection, governmental crisis management, restricted social contact, work-related problems, restricted activity, and difficult housing conditions. Conclusions We identified stressors, risk, and protective factors that may help identify individuals at higher risk for adjustment disorder.
sj-pdf-1-asu-10.1177_00031348211054074 – Supplemental Material for Risk Factors of Mortality in Patients Hospitalized With Chronic Duodenal Ulcers
Creators: name: Lin, Nicole
name: Smiley, Abbas
name: Goud, Manoj
name: Lin, Cynthia
name: Latifi1, Rifat
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-asu-10.1177_00031348211054074 for Risk Factors of Mortality in Patients Hospitalized With Chronic Duodenal Ulcers by Nicole Lin, Abbas Smiley, Manoj Goud, Cynthia Lin, and Rifat Latifi
title: Grazing-incidence synchrotron radiation diffraction studies on irradiated Ce-doped and pristine Y-stabilized ZrO2 at the Rossendorf beamline
Creators: name: Svitlyk, Volodymyr
name: Santos, Luiza Braga Ferreira Dos
name: Niessen, Jonas
name: Gilson, Sara
name: Marquardt, Julien
name: Findeisen, Stefan
name: Richter, Selina
name: Akhmadaliev, Shavkat
name: Huittinen, Nina
name: Hennig, Christoph
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: yttria-stabilized zirconia
subject: irradiation
subject: synchrotron radiation
subject: grazing incidence diffraction
subject: microstrain
classificationCode: 530
subject: Physik

description: In this work, Ce-doped yttria-stabilized zirconia (YSZ) and pure YSZ phases were subjected to irradiation with 14 MeV Au ions. Irradiation studies were performed to simulate long-term structural and microstructural damage due to self-irradiation in YSZ phases hosting alpha-active radioactive species. It was found that both the Ce-doped YSZ and the YSZ phases had a reasonable tolerance to irradiation at high ion fluences and the bulk crystallinity was well preserved. Nevertheless, local microstrain increased in all compounds under study after irradiation, with the Ce-doped phases being less affected than pure YSZ. Doping with cerium ions increased the microstructural stability of YSZ phases through a possible reduction in the mobility of oxygen atoms, which limits the formation of structural defects. Doping of YSZ with tetravalent actinide elements is expected to have a similar effect. Thus, YSZ phases are promising for the safe long-term storage of radioactive elements. Using synchrotron radiation diffraction, measurements of the thin irradiated layers of the Ce-YSZ and YSZ samples were performed in grazing incidence (GI) mode. A corresponding module for measurements in GI mode was developed at the Rossendorf Beamline and relevant technical details for sample alignment and data collection are also presented.
Additional file 1 of Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Creators: name: Kraft, Theresa
name: Grützmann, Konrad
name: Meinhardt, Matthias
name: Meier, Friedegund
name: Westphal, Dana
name: Seifert, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1: Dendrogram of the joint hierarchical clustering of individual melanoma metastases and normal tissue samples.
Supplemental Material, sj-pdf-1-vet-10.1177_03009858211067461 - An inherited night blindness in Wiltshire sheep
Creators: name: Hunt, Hayley
name: Dittmer, Keren E.
name: Garrick, Dorian J.
name: Fairley, Robert A.
name: Heap, Stephen J.
name: Jolly, Robert D.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, sj-pdf-1-vet-10.1177_03009858211067461 for An inherited night blindness in Wiltshire sheep by Hayley Hunt, Keren E. Dittmer, Dorian J. Garrick, Robert A. Fairley, Stephen J. Heap and Robert D. Jolly in Veterinary Pathology
title: Microbial Colonization of Explants after Osteosynthesis in Small Animals: Incidence and Influencing Factors
Creators: name: Candela Andrade, Mario
name: Slunsky, Pavel
name: Pagel, Tanja
name: Rus Aznar, Ignacio De
name: Brunnberg, Mathias
name: Brunnberg, Leo
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: infection
subject: hardware
subject: implants
subject: dogs
subject: cats
classificationCode: 616
subject: Krankheiten
classificationCode: 615
subject: Pharmakologie, Therapeutik

description: Despite recent advancements in antibiotics, hygienic measures, and peri-operative systemic antibiotics, post-operative infections in osteosynthesis remain prevalent and continue to be among the most common surgical complications, leading to delayed fracture healing, osteomyelitis, implant loosening, and loss of function. Osteosynthesis implants are routinely utilized in veterinary medicine and the current study investigates the microbial colonization of implants following osteosynthesis in small animals, along with its incidence and influencing factors. The results are analyzed in regard to correlations between infection, patient, disease progression, and radiographic images, as well as other factors that may promote infection. Seventy-one explants from sixty-five patients were examined and evaluated for microbial colonization. Factors like body weight and age, location and type of plate and additional injuries like lung lesions, the surgeon’s experience, or the number of people present during the surgical procedure seem to influence the development of an infection. Of the animals, 60% showed osteolytic changes and 73.3% of those with dysfunctional mobility had an implant infection. Microorganisms were detected in almost 50% of the explants, but a clinically relevant infection was only present in five patients (7.3%), suggesting that the presence of microorganisms on an implant does not necessarily lead to treatment complications.
Additional file 2 of Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Creators: name: Kraft, Theresa
name: Grützmann, Konrad
name: Meinhardt, Matthias
name: Meier, Friedegund
name: Westphal, Dana
name: Seifert, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2: Histogram of gene expression log $$_2$$ 2 -ratios across all patient-matched intra- vs. extracranial melanoma metastasis pairs.
title: Late Eocene to early Oligocene productivity events in the proto-Southern Ocean and correlation to climate change
Creators: name: Rodrigues De Faria, Gabrielle
name: Lazarus, David
name: Renaudie, Johan
name: Stammeier, Jessica
name: Özen, Volkan
name: Struck, Ulrich
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: proto-Southern Ocean
subject: climate change
subject: productivity events
classificationCode: 550
subject: Geowissenschaften

description: The Eocene–Oligocene transition (EOT, ca. 40–33 Ma) marks a transformation from a largely ice-free to an icehouse climate mode that is well recorded by oxygen-stable isotopes and sea surface temperature proxies. Opening of the Southern Ocean gateways and decline in atmospheric carbon dioxide levels have been considered as factors in this global environmental transformation and the growth of ice sheets in Antarctica during the Cenozoic. A more comprehensive understanding is still needed of the interplay between forcing versus response, the correlation among environmental changes, and the involved feedback mechanisms. In this study, we investigate the spatio-temporal variation in export productivity using biogenic Ba (bio-Ba) from Ocean Drilling Program (ODP) sites in the Southern Ocean, focusing on possible mechanisms that controlled them as well as the correlation of export productivity changes to changes in the global carbon cycle. We document two high export productivity events in the Southern Ocean during the late Eocene (ca. 37 and 33.5 Ma) that correlate to proposed gateway-driven changes in regional circulation and to changes in global atmospheric pCO2 levels. Our findings suggest that paleoceanographic changes following Southern Ocean gateway openings, along with more variable increases in circulation driven by episodic Antarctic ice sheet expansion, enhanced export production in the Southern Ocean from the late Eocene through early Oligocene. These factors may have played a role in episodic atmospheric carbon dioxide reduction, contributing to Antarctic glaciation during the Eocene–Oligocene transition.
sj-docx-1-cad-10.1177_00111287211061719 – Supplemental material for Does the Premium Fit the Risk? The Role of Criminal Escalation in Case Processing
Creators: name: Yan, Shi
name: Walker, Jason W.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, sj-docx-1-cad-10.1177_00111287211061719 for Does the Premium Fit the Risk? The Role of Criminal Escalation in Case Processing by Shi Yan and Jason W. Walker in Crime & Delinquency
title: Biradicals based on PROXYL containing building blocks for efficient dynamic nuclear polarization in biotolerant media
Creators: name: Herr, Kevin
name: Höfler, Mark V.
name: Heise, Henrike
name: Aussenac, Fabien
name: Kornemann, Felix
name: Rosenberger, David
name: Brodrecht, Martin
name: Oliveira Jr., Marcos De
name: Buntkowsky, Gerd
name: Gutmann, Torsten
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Biradicals
subject: Peptides
subject: Spin labeling
subject: Solid-state nmr
subject: Dynamic nuclear polarization
classificationCode: 530
subject: Physik

description: A versatile strategy for synthesizing tailored peptide based biradicals is presented. By labeling the protected amino acid hydroxyproline with PROXYL via the OH functionality and using this building block in solid phase peptide synthesis (SPPS), the obtained peptides become polarization agents for DNP enhanced solid-state NMR in biotolerant media. To analyze the effect of the radical position on the enhancement factor, three different biradicals are synthesized. The PROXYL spin-label is inserted in a collagen inspired artificial peptide sequence by binding through the OH group of the hydroxyproline moieties at specific position in the chain. This labeling strategy is universally applicable for any hydroxyproline position in a peptide sequence since solid-phase peptide synthesis is used to insert the building block. High performance liquid chromatography (HPLC) and mass spectrometry (MS) analyses show the successful introduction of the spin label in the peptide chain and electron paramagnetic resonance (EPR) spectroscopy confirms its activity. Dynamic nuclear polarization (DNP) enhanced solid-state nuclear magnetic resonance (NMR) experiments performed on frozen aqueous glycerol-d8 solutions containing these peptide radicals show significantly higher enhancement factors of up to 45 in 1H→13C cross polarization magic angle spinning (CP MAS) experiments compared to an analogous mono-radical peptide including this building block (ε ≈ 14). Compared to commercial biradicals such as AMUPol for which enhancement factors > 100 have been obtained in the past and which have been optimized in their structure, the obtained enhancement up to 45 for our biradicals presents a significant progress in radical design.
Additional file 1 of Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples
Creators: name: Brettoni, Cecilia
name: Muzzi, Alessandro
name: Rondini, Simona
name: Weynants, Vincent
name: Rossi Paccani, Silvia
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. PCR primer sequences for NTHi and Mcat genes. Figure S1. NTHi gene RNA concentrations in NTHi positive samples did not differ between stable visits (ST) and exacerbation visits (EX). Figure S2. Mcat gene RNA concentrations in Mcat positive samples did not differ between stable visits (ST) and exacerbation visits (EX). Additional methods.
title: Icy ocean worlds - astrobiology research in Germany
Creators: name: Klenner, Fabian
name: Baqué, Mickael
name: Beblo-Vranesevic, Kristina
name: Bönigk, Janine
name: Boxberg, Marc S.
name: Dachwald, Bernd
name: Digel, Ilya
name: Elsaesser, Andreas
name: Espe, Clemens
name: Funke, Oliver
name: Hauber, Ernst
name: Heinen, Dirk
name: Hofmann, Florence
name: Hortal Sánchez, Lucía
name: Khawaja, Nozair
name: Napoleoni, Maryse
name: Plesa, Ana-Catalina
name: Postberg, Frank
name: Purser, Autun
name: Rückriemen-Bez, Tina
name: Schröder, Susanne
name: Schulze-Makuch, Dirk
name: Ulamec, Stephan
name: Vera, Jean-Pierre Paul De
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: subsurface oceans
subject: space missions
subject: habitability
subject: icy moons
subject: solar system exploration
subject: Deutsche Astrobiologische Gesellschaft (DAbG)
subject: ocean worlds
subject: German Aerospace Center (DLR)
classificationCode: 520
subject: Astronomie und zugeordnete Wissenschaften

description: Icy bodies with subsurface oceans are a prime target for astrobiology investigations, with an increasing number of scientists participating in the planning, development, and realization of space missions to these worlds. Within Germany, the Ocean Worlds and Icy Moons working group of the German Astrobiology Society provides an invaluable platform for scientists and engineers from universities and other organizations with a passion for icy ocean worlds to share knowledge and start collaborations. We here present an overview about astrobiology research activities related to icy ocean worlds conducted either in Germany or in strong collaboration with scientists in Germany. With recent developments, Germany offers itself as a partner to contribute to icy ocean world missions.
Beaconing D3.3 – Learning Environment System Specification
Creators: name: Bourazeri, Aikaterini
name: Morini, Luca
name: Koula Charitonos
name: Arnab, Sylvester
Publisher: name: Zenodo
Year: 2018

description: The Beaconing project will provide different learning scenarios supported by different technologies for teaching and learning in an inclusive society. There is an explicit focus on skills, competencies, strategies, learning outcomes and learning disabilities closely related to 21st century.

This document includes the design of a framework for problem-based learning, which will encapsulate the mechanics of different learning models for different learning environments. An extensive literature review on pervasive, gamified and problem-based learning has been included to support the proposed Beaconing Taxonomy on which the different play-lesson scenarios are based on.
Additional file 3 of Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Creators: name: Kraft, Theresa
name: Grützmann, Konrad
name: Meinhardt, Matthias
name: Meier, Friedegund
name: Westphal, Dana
name: Seifert, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3: Extended overview of signaling and immune pathway alterations for all patient-matched melanoma metastasis pairs.
title: COVID-19 pandemic-related drugs and microplastics from mask fibers jointly affect soil functions and processes
Creators: name: Cruz, Jeane Dela
name: Lammel, Daniel
name: Kim, Shin Woong
name: Bi, Mohan
name: Rillig, Matthias
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Pharmaceutical products
subject: FFP2 mask
subject: Global change factors
subject: Microbial activity
subject: Environmental side effects
subject: Soil pollution
classificationCode: 570
subject: Biowissenschaften; Biologie

description: The COVID-19 pandemic has led to an unprecedented increase in pharmaceutical drug consumption and plastic waste disposal from personal protective equipment. Most drugs consumed during the COVID-19 pandemic were used to treat other human and animal diseases. Hence, their nearly ubiquitous presence in the soil and the sharp increase in the last 3 years led us to investigate their potential impact on the environment. Similarly, the compulsory use of face masks has led to an enormous amount of plastic waste. Our study aims to investigate the combined effects of COVID-19 drugs and microplastics from FFP2 face masks on important soil processes using soil microcosm experiments. We used three null models (additive, multiplicative, and dominative models) to indicate potential interactions among different pharmaceutical drugs and mask MP. We found that the multiple-factor treatments tend to affect soil respiration and FDA hydrolysis more strongly than the individual treatments. We also found that mask microplastics when combined with pharmaceuticals caused greater negative effects on soil. Additionally, null model predictions show that combinations of high concentrations of pharmaceuticals and mask MP have antagonistic interactions on soil enzyme activities, while the joint effects of low concentrations of pharmaceuticals (with or without MP) on soil enzyme activities are mostly explained by null model predictions. Our study underscores the need for more attention on the environmental side effects of pharmaceutical contamination and their potential interactions with other anthropogenic global change factors.
sj-docx-3-tam-10.1177_17588359211059874 – Supplemental material for Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT)
Creators: name: Addeo, Alfredo
name: Hochmair, Maximilian
name: Janzic, Urska
name: Dudnik, Elizabeth
name: Charpidou, Andriani
name: Płużanński, Adam
name: Ciuleanu, Tudor
name: Donev, Ivan Shterev
name: Elbaz, Judith
name: Aarøe, Jørgen
name: Ott, René
name: Peled, Nir
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-3-tam-10.1177_17588359211059874 for Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT) by Alfredo Addeo, Maximilian Hochmair, Urska Janzic, Elizabeth Dudnik, Andriani Charpidou, Adam Płużanński, Tudor Ciuleanu, Ivan Shterev Donev, Judith Elbaz, Jørgen Aarøe, René Ott and Nir Peled in Therapeutic Advances in Medical Oncology
Additional file 4 of Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Creators: name: Kraft, Theresa
name: Grützmann, Konrad
name: Meinhardt, Matthias
name: Meier, Friedegund
name: Westphal, Dana
name: Seifert, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S4: Comparison of the expression behavior of genes associated with the brain-like phenotype considering intracranial metastases and normal brain tissues.
Additional file 5 of Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Creators: name: Kraft, Theresa
name: Grützmann, Konrad
name: Meinhardt, Matthias
name: Meier, Friedegund
name: Westphal, Dana
name: Seifert, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Figure S5: Expression behavior of the 103 candidate genes comparing intracranial metastases and normal brain tissues.
sj-pdf-1-smm-10.1177_09622802211064996 - Supplemental material for Stopping rules for phase I clinical trials with dose expansion cohorts
Creators: name: Devlin, Sean M
name: Iasonos, Alexia
name: O’Quigley, John
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-smm-10.1177_09622802211064996 for Stopping rules for phase I clinical trials with dose expansion cohorts by Sean M Devlin, Alexia Iasonos and John O’Quigley in Statistical Methods in Medical Research
sj-pdf-1-imr-10.1177_03000605211066397 - Supplemental material for Minimally invasive management of large duodenal lipoma: endoscopic submucosal dissection
Creators: name: Yang, Bin
name: Jiang, Fei
name: Lu, Pinxiang
name: Han, Huazhong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211066397 for Minimally invasive management of large duodenal lipoma: endoscopic submucosal dissection by Bin Yang, Fei Jiang, Pinxiang Lu and Huazhong Han in Journal of International Medical Research
Der Pflegenotstand der 1960er Jahre: Genese und kommunale Krisenbewältigung (EHMH)
Creators: name: Pfütsch, Pierre
name: Kreutzer, Susanne
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 420505
subject: Nursing workforce

description: The nursing crisis that developed in West Germany in the 1960s was considered a majorsocial challenge. The causes were complex and lay primarily in the denominationalmotherhouse system, which gradually began to erode around this time. The problemof a shortage of young staff went in tandem with the dissolution of the old structuresand was exacerbated by an expansion of the hospitals, which required more andmore personnel. The responses varied greatly from region to region. The example ofthe city of Stuttgart serves an in-depth examination both of federal policy strategiesfor solving the problem and of the specific implementation of these strategies withinlocal communities. Measures included advertising for new staff, diversifying training,recruiting foreign nursing staff, and improving working conditions.
sj-pdf-1-ajs-10.1177_03635465211062609 – Supplemental material for ACL Reconstruction Combined With the Arnold-Coker Modification of the MacIntosh Lateral Extra-articular Tenodesis: Long-term Clinical and Radiological Outcomes
Creators: name: Viglietta, Edoardo
name: Ponzo, Antonio
name: Monaco, Edoardo
name: Iorio, Raffaele
name: Drogo, Piergiorgio
name: Andreozzi, Valerio
name: Conteduca, Fabio
name: Ferretti, Andrea
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211062609 for ACL Reconstruction Combined With the Arnold-Coker Modification of the MacIntosh Lateral Extra-articular Tenodesis: Long-term Clinical and Radiological Outcomes by Edoardo Viglietta, Antonio Ponzo, Edoardo Monaco, Raffaele Iorio, Piergiorgio Drogo, Valerio Andreozzi, Fabio Conteduca and Andrea Ferretti in The American Journal of Sports Medicine
title: Phylogenomics of the pantropical Connaraceae: revised infrafamilial classification and the evolution of heterostyly
Creators: name: Vos, Jurriaan M. De
name: Streiff, Serafin J. R.
name: Bachelier, Julien B.
name: Epitawalage, Niroshini
name: Maurin, Olivier
name: Forest, Félix
name: Baker, William J.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Ancient DNA
subject: Angiosperms353
subject: Distyly
subject: Molecular phylogenetics
subject: Oxalidales
subject: Tristyly
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Connaraceae is a pantropical family of about 200 species containing lianas and small trees with remarkably diverse floral polymorphisms, including distyly, tristyly, homostyly, and dioecy. To date, relationships within the family have not been investigated using a targeted molecular phylogenetic treatment, severely limiting systematic understanding and reconstruction of trait evolution. Accordingly, their last infrafamilial classification was based only on morphological data. Here, we used phylogenomic data obtained using the Angiosperms353 nuclear target sequence capture probes, sampling all tribes and almost all genera, entirely from herbarium specimens, to revise infrafamilial classification and investigate the evolution of heterostyly. The backbone of the resulting molecular phylogenetic tree is almost entirely resolved. Connaraceae consists of two clades, one containing only the African genus Manotes (4 or 5 species), which we newly recognize at the subfamily level. Vegetative and reproductive synapomorphies are proposed for Manotoideae. Within Connaroideae, Connareae is expanded to include the former Jollydoreae. The backbone of Cnestideae, which contains more than half of the Connaraceae species, remains incompletely resolved. Reconstructions of reproductive system evolution are presented that tentatively support tristyly as the ancestral state for the family, with multiple parallel losses, in agreement with previous hypotheses, plus possible re-gains. However, the great diversity of stylar polymorphisms and their phylogenetic lability preclude a definitive answer. Overall, this study reinforces the usefulness of herbarium phylogenomics, and unlocks the reproductive diversity of Connaraceae as a model system for the evolution of complex biological phenomena.
Additional file 1 of Facilitators and barriers to engaging communities in health service research on dengue control in Indo-Pacific region: a systematic review
Creators: name: Naing, Cho
name: Htet, Norah Htet
name: Tung, Wong Siew
name: Aung, Htar Htar
name: Whittaker, Maxine A.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
title: Limited role of fungal diversity in maintaining soil processes in grassland soil under concurrent fungicide stress
Creators: name: Cruz, Jeane A. Dela
name: Camenzind, Tessa
name: Xu, Baile
name: Rillig, Matthias C.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Fungicide mixture
subject: Fungal diversity
subject: Soil processes
subject: Grassland fungi
subject: Modes of action (MoA)
classificationCode: 579
subject: Mikroorganismen, Pilze, Algen

description: Background Fungicides are an effective tool for protecting crops and maintaining a steady food supply. However, as pathogens continue to evolve, it is crucial to prolong the effectiveness of fungicides by delaying resistance development. A key strategy to achieving this is to combine or rotate fungicides with different modes of action. As fungicides lack specificity, they inevitably affect both pathogenic and non-pathogenic fungi when surrounding environments are unintentionally contaminated. Our study aims to investigate the effects of recommended application methods to prevent resistance development, specifically repeated-single fungicide, simultaneous mixture, and sequential applications on non-target soil fungi, and the subsequent impacts on important soil processes. We used fungicides with different modes of action on soil microcosms inoculated with fungi at varying levels of diversity (3, 5, and 8 species) isolated from a protected grassland. Results We found that repeated treatments of individual isopyrazam and prothioconazole differentially inhibited fungal activity. Although mixture applications are considered more protectant against crop pathogen resistance than repeated application, our study revealed stronger negative effects of simultaneous application on saprobic fungi and consequently on soil processes. However, contrary to expectations, higher fungal diversity did not translate to improved soil function under these conditions. Conclusions The simultaneous application of fungicides with different modes of action (MoA) has more pronounced non-target effects on soil compared to the individual or sequential application of fungicides. These non-target effects extend beyond the intended control of pathogenic fungi, impacting saprobic and beneficial soil microbes and the critical processes they drive. When fungicides are applied concurrently, microbial activities in the soil are significantly altered, even in soils with high microbial diversity. Our study emphasizes the importance of carefully considering the unintended consequences of fungicide use in agriculture. As we strive for a secure food supply, it is crucial to investigate the broader environmental impacts of these chemical interventions, including their effects on non-pathogenic fungi and overall soil health.
sj-docx-1-pss-10.1177_09567976211015941 – Supplemental material for A Personal Model of Trumpery: Linguistic Deception Detection in a Real-World High-Stakes Setting
Creators: name: Van Der Zee, Sophie
name: Poppe, Ronald
name: Havrileck, Alice
name: Baillon, Aurélien
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-docx-1-pss-10.1177_09567976211015941 for A Personal Model of Trumpery: Linguistic Deception Detection in a Real-World High-Stakes Setting by Sophie Van Der Zee, Ronald Poppe, Alice Havrileck and Aurélien Baillon in Psychological Science
Additional file 2 of Facilitators and barriers to engaging communities in health service research on dengue control in Indo-Pacific region: a systematic review
Creators: name: Naing, Cho
name: Htet, Norah Htet
name: Tung, Wong Siew
name: Aung, Htar Htar
name: Whittaker, Maxine A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Supplementary Material 2
title: Organotellurium(II) and -(IV) Compounds with Picolinoylbis(thioureas): From Simple 1 : 1 Adducts to Multimetallic Aggregates
Creators: name: Santos, Sailer S. Dos
name: Schwade, Vania D.
name: Schulz Lang, Ernesto
name: Pham, Chien Thang
name: Roca Jungfer, Maximilian
name: Abram, Ulrich
name: Nguyen, Hung Huy
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Tellurium
subject: Transition metals
subject: Self-assembly
subject: Aroylthioureas
subject: Density functional calculations
classificationCode: 540
subject: Chemie und zugeordnete Wissenschaften

description: Reactions of 2,6-dipicolinoylbis(N,N-diethylthiourea) (H2LEt) with common tellurium(IV) starting materials such as PhTeBr3 or TeBr4 yield various tellurium(IV) and tellurium(II) compounds depending on the conditions applied. Equimolar amounts of H2LEt and PhTeBr3 give the 1 : 1 complex [PhTeIVBr3(H2LEt)], while with an excess of H2LEt, the tellurium compound is partially reduced and a {PhTeII}+ building block coordinates to both sulfur atoms of H2LEt under the formation of the ion pair [PhTeII(H2LEt)][PhTeIVBr4]. Similar reactions between H2LEt and TeBr4 give the neutral monomer [TeIIBr2(H2LEt)] or the coordination polymer [TeIIBr2(H2LEt)]∞. The latter compound is also formed with the assistance of Pb2+ ions. While the lead ions do not appear in the isolated product, similar reactions with transition metal ions such as Ni2+, Mn2+, or Co2+ result in the formation of heterobimetallic complexes, in which Te(II) building blocks are directed to the sulfur atoms of the deprotonated ligand {H2LEt2-S,S}2−, while the transition metal ions occupy central coordination positions between two of the organic ligands using the pyridine nitrogen atom, carbonyl oxygen atom(s) and/or the nitrogen atoms of the thiourea units.
title: Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Creators: name: Ledwith, Rico
name: Stobernack, Tobias
name: Bergert, Antje
name: Bahl, Aileen
name: Pink, Mario
name: Haase, Andrea
name: Dumit, Verónica I.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: New approach methodologies (NAMs)
subject: Toxicity mechanisms
subject: Cell culture conditions,
subject: THP-1 differentiation process
subject: Passage numbers
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hampered by high variances due to different experimental setups. In addition, cell culture conditions can have a huge impact on the outcome. This study systematically investigates the impact of experimental parameters on the proteomic profiles of commonly used cell lines—A549, differentiated THP-1 macrophage-like cells, and NR8383—for toxicity studies. The work focuses on analyzing the influence at the proteome level of cell culture setup involving different vessels, cell passage numbers, and post-differentiation harvesting time, aiming to improve the reliability of proteomic analyses for hazard assessment. Mass-spectrometry-based proteomics was utilized for accurate protein quantification by means of a label-free approach. Our results showed that significant proteome variations occur when cells are cultivated under different setups. Further analysis of these variations revealed their association to specific cellular pathways related to protein misfolding, oxidative stress, and proteasome activity. Conversely, the influence of cell passage numbers on the proteome is minor, suggesting a reliable range for conducting reproducible biological replicates. Notable, substantial proteome alterations occur over-time post-differentiation of dTHP-1 cells, particularly impacting pathways crucial for macrophage function. This finding is key for the interpretation of experimental results. These results highlight the need for standardized culture conditions in proteomic-based evaluations of treatment effects to ensure reliable results, a prerequisite for achieving regulatory acceptance of proteomics data.
Additional file 3 of Facilitators and barriers to engaging communities in health service research on dengue control in Indo-Pacific region: a systematic review
Creators: name: Naing, Cho
name: Htet, Norah Htet
name: Tung, Wong Siew
name: Aung, Htar Htar
name: Whittaker, Maxine A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Supplementary Material 3
sj-docx-1-aut-10.1177_13623613211065540 – Supplemental material for Contingency-based delay to reinforcement following functional communication training for autistic individuals: A multilevel meta-analysis
Creators: name: Muharib, Reem
name: Dowdy, Art
name: Rajaraman, Adithyan
name: Jessel, Joshua
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-1-aut-10.1177_13623613211065540 for Contingency-based delay to reinforcement following functional communication training for autistic individuals: A multilevel meta-analysis by Reem Muharib, Art Dowdy, Adithyan Rajaraman and Joshua Jessel in Autism
title: Influence of Preprocessing Methods of Automated Milking Systems Data on Prediction of Mastitis with Machine Learning Models
Creators: name: Kashongwe, Olivier
name: Kabelitz, Tina
name: Ammon, Christian
name: Minogue, Lukas
name: Doherr, Marcus G.
name: Silva Boloña, Pablo
name: Amon, Thomas
name: Amon, Barbara
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: oversampling
subject: undersampling
subject: missing-value imputation
subject: dairy cows
subject: performancemetrics
classificationCode: 637
subject: Milchverarbeitung und verwandte Produkte

description: Missing data and class imbalance hinder the accurate prediction of rare events such as dairy mastitis. Resampling and imputation are employed to handle these problems. These methods are often used arbitrarily, despite their profound impact on prediction due to changes caused to the data structure. We hypothesize that their use affects the performance of ML models fitted to automated milking systems (AMSs) data for mastitis prediction. We compare three imputations—simple imputer (SI), multiple imputer (MICE) and linear interpolation (LI)—and three resampling techniques: Synthetic Minority Oversampling Technique (SMOTE), Support Vector Machine SMOTE (SVMSMOTE) and SMOTE with Edited Nearest Neighbors (SMOTEEN). The classifiers were logistic regression (LR), multilayer perceptron (MLP), decision tree (DT) and random forest (RF). We evaluated them with various metrics and compared models with the kappa score. A complete case analysis fitted the RF (0.78) better than other models, for which SI performed best. The DT, RF, and MLP performed better with SVMSMOTE. The RF, DT and MLP had the overall best performance, contributed by imputation or resampling (SMOTE and SVMSMOTE). We recommend carefully selecting resampling and imputation techniques and comparing them with complete cases before deciding on the preprocessing approach used to test AMS data with ML models.