title: ÐÐµÑ Ð°Ð½Ð¸Ð·Ð¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¸Ð½Ð´ÑÐºÑÐ¾ÑÐ¾Ð² ÑÐ¸Ð½ÑÐµÐ·Ð° Ð±ÐµÐ»ÐºÐ¾Ð² ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð¸Ð· ÐºÐ»Ð°ÑÑÐ° Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The mechanism of induction of heat shock protein synthesis by pyrrolylazinesâ derivatives
Creators: name: Ð¡Ð°ÑÐ°ÑÐ¾Ð², ÐÐ»ÐµÐºÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ñ
Ð±ÐµÐ»ÐºÐ¾Ð²ÑÐµ Ð°Ð³ÑÐµÐ³Ð°ÑÑ
ÑÐ°Ð¿ÐµÑÐ¾Ð½Ñ
Ð±ÐµÐ»ÐºÐ¸ ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ°
ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ ÑÐ°ÐºÑÐ¾Ñ ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° 1
ÐºÐ°Ð·ÐµÐ¸Ð½ ÐºÐ¸Ð½Ð°Ð·Ð° 2Î±
Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ñ
Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ
neurodegeneration
protein aggregates
chaperones
heat shock proteins
heat shock transcription factor 1
casein kinase 2Î±
pyrrolylazines
mechanism of action

description: Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð° ÑÐ°Ð¿ÐµÑÐ¾Ð½-Ð¸Ð½Ð´ÑÑÐ¸ÑÑÑÑÐµÐ³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¼Ð°Ð»ÑÑ Ð¼Ð¾Ð»ÐµÐºÑÐ» Ð¸Ð· ÐºÐ»Ð°ÑÑÐ° Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð¾Ð². Ð Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ ÐºÐ»ÐµÑÐºÐ¸ A549 ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð»ÑÐ³ÐºÐ¾Ð³Ð¾ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¸ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ â Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð¾Ð² Ð³ÑÑÐ¿Ð¿Ñ SD. ÐÐ· ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð¿ÑÐ¾Ð²ÐµÐ´ÑÐ½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ»ÐµÐ´ÑÐµÑ, ÑÑÐ¾ Ð¿ÑÐ¸ÑÑÑÑÑÐ²ÑÑÑÐ¸Ðµ Ð² ÐºÑÐ»ÑÑÑÑÐ°Ð»ÑÐ½Ð¾Ð¹ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¹ ÑÑÐµÐ´Ðµ Ð¼Ð°Ð»ÑÐµ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ Ð³ÑÑÐ¿Ð¿Ñ SD Ð¸Ð· ÐºÐ»Ð°ÑÑÐ° Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð¾Ð² ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ñ ÑÐ²ÑÐ·ÑÐ²Ð°ÑÑÑÑ Ñ ÐºÐ°Ð·ÐµÐ¸Ð½ ÐºÐ¸Ð½Ð°Ð·Ð¾Ð¹ 2Î± â ÐºÐ°ÑÐ°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ±ÑÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ¹ ÑÐµÑÐ¸Ð½-ÑÑÐµÐ¾Ð½Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¿ÑÐ¾ÑÐµÐ¸Ð½ÐºÐ¸Ð½Ð°Ð·Ñ, ÐºÐ¾ÑÐ¾ÑÐ°Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð° ÑÐ¾ÑÑÐ¾ÑÐ¸Ð»Ð¸ÑÐ¾Ð²Ð°ÑÑ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ ÑÐ°ÐºÑÐ¾Ñ ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° HSF1 Ð¿Ð¾ Ð°Ð¼Ð¸Ð½Ð¾ÐºÐ¸ÑÐ»Ð¾ÑÐ½ÑÐ¼ Ð¾ÑÑÐ°ÑÐºÐ°Ð¼ Ser-303 Ð¸ Ser-307, Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÑÑ ÐµÐ³Ð¾ ÑÐ°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼ Ð½Ð° ÑÐ±Ð¸ÐºÐ²Ð¸ÑÐ¸Ð½-Ð¾Ð¿Ð¾ÑÑÐµÐ´Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¿ÑÐ¾ÑÐµÐ°ÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ Ð´ÐµÐ³ÑÐ°Ð´Ð°ÑÐ¸Ñ. ÐÐ´Ð½Ð°ÐºÐ¾, Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾, ÑÑÐ¾ Ð² ÑÐ²ÑÐ·Ð°Ð½Ð½Ð¾Ð¼ Ñ Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð°Ð¼Ð¸ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÑÐµÐ¸Ð½ÐºÐ¸Ð½Ð°Ð·Ð° ÑÐµÑÑÐµÑ ÑÐ²Ð¾Ñ ÑÐµÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ. Ð­ÑÐ¾ Ð²ÐµÐ´ÑÑ Ðº ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ñ Ð´Ð¾Ð»Ð¸ HSF1, Ð¿ÐµÑÐµÑÐµÐ´ÑÐµÐ³Ð¾ Ð² ÑÑÐ¸Ð¼ÐµÑÐ½ÑÑ ÑÐ¾ÑÐ¼Ñ Ð¸ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾Ð³Ð¾ ÑÐµÐ¼ ÑÐ°Ð¼ÑÐ¼ Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°ÑÑ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² ÐÐ¢Ð¨, ÑÑÐ¾ Ð² Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÐ²Ð¸Ð¸ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð² ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð² ÐºÐ»ÐµÑÐºÐµ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ ÑÑÐ¸ÑÐ°ÑÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð»Ð°Ð·Ð¸Ð½Ð¾Ð² Ð³ÑÑÐ¿Ð¿Ñ SD Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐ¼Ð¸ Ð½ÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ°Ð¼Ð¸ Ñ Ð¸Ð·Ð²ÐµÑÑÐ½ÑÐ¼ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ, ÑÑÐ¾ Ð²ÑÐ´ÐµÐ»ÑÐµÑ Ð¸Ñ ÑÑÐµÐ´Ð¸ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¾Ð², Ð´ÐµÐ¹ÑÑÐ²ÑÑÑÐ¸Ñ Ð»Ð¸Ð±Ð¾ ÑÐµÑÐµÐ· Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ°Ð¿ÐµÑÐ¾Ð½Ð¾Ð², Ð»Ð¸Ð±Ð¾ Ð¿Ð¾ Ð½ÐµÐ¸Ð·Ð²ÐµÑÑÐ½Ð¾Ð¼Ñ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ñ.
description: The given work is devoted to study the mechanism of chaperone-inducing action of small molecules from the class of pyrrolylazines. There were used human lung carcinoma cells A549 and the SD group which consist of pyrrolylazinesâ derivatives. We demonstrate that small molecules of the SD group from the class of pyrrolylazines presented in the culture cell medium can bind to casein kinase 2Î±, a catalytic subunit of serine-threonine protein kinase, which is able to phosphorylate the HSF1 at amino acid residues Ser-303 and Ser-307, thus directing it to ubiquitin-dependent proteasomal degradation. However, it has been shown that in the pyrrolylazine-bound state, protein kinase loses its enzymatic activity. It leads to an increasing of the proportion of HSF1, which has passed into a trimeric form and is thereby capable of inducing the expression of HSPâs genes, which subsequently leads to the accumulation of heat shock proteins in the cell. Thus, the results of the study allow us to consider pyrrolylazinesâ derivatives of the SD group as potential neuroprotectors with a known mechanism of action, which distinguishes it from analogues acting either through inhibition of chaperones or by an unknown mechanism.