cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transverse localization in nonlinear photonic lattices with second-order coupling
Creators: name: Golshani, M.
name: Bahrampour, A. R.
name: Langari, A.
name: Szameit, A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We investigate numerically the effect of long-range interaction on the transverse localization of light. To this end, nonlinear zigzag optical waveguide lattices are applied, which allows precise tuning of the second-order coupling. We find that localization is hindered by coupling between next-nearest lattice sites. Additionally, (focusing) nonlinearity facilitates localization with increasing disorder, as long as the nonlinearity is sufficiently weak. However, for strong nonlinearities, increasing disorder results in weaker localization. The threshold nonlinearity, above which this anomalous result is observed grows with increasing second-order coupling.
description: Accepted to PRA, 5 pages, 9 figures
Soluble Stoichiometric Complexes from Poly(N-ethyl-4-vinylpyridinium) Cations and Poly(ethylene oxide)-block-polymethacrylate Anions
Creators: name: Eisenberg, Adi
name: Kabanov, Victor A.
name: Yu, Kui
name: Kabanov, Alexander V.
name: Bronich, Tatiana K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Block ionomer complexes formed between the block copolymers containing poly(sodium
        methacrylate) (PMANa) and poly(ethylene oxide) (PEO) segments and poly(N-ethyl-4-vinylpyridinium
        bromide) (PEVP) were investigated. The data obtained suggest that (i) these systems form water-soluble
        stoichiometric complexes; (ii) these complexes are stable in a much broader pH range compared to the
        polyelectrolyte complexes prepared from homopolymers; (iii) they self-assemble to form the core of a micelle
        comprised of neutralized polyions, surrounded by the PEO corona; (iv) they are salt sensitive since they
        fall apart as the salt concentration increases beyond a critical value; and (v) they can participate in the
        cooperative polyion substitution reactions. Therefore, these complexes represent a new class of hybrid
        materials which combine properties of polyelectrolyte complexes and block copolymer micelles.
title: Möglichkeiten und Selbstverwirklichung adeliger Frauen an der Wende des hohen zum späten Mittelalter - erörtert am Beispiel der heiligen Elisabeth von Marburg, Landgräfin von Thüringen
Creators: name: Best, Werner
Publisher: name: University Library Heidelberg
Year: 2016

description: [nicht vorhanden / not available]
Impacts of Formula Supplemented with Milk Fat Globule Membrane on the Neurolipidome of Brain Regions of Piglets
Creators: name: Fraser, Karl
name: Ryan, Leigh
name: Dilger, Ryan N.
name: Dunstan, Kelly
name: Armstrong, Kelly
name: Peters, Jason
name: Stirrat, Hedley
name: Haggerty, Neill
name: MacGibbon, Alastair K. H.
name: Dekker, James
name: Young, Wayne
name: Roy, Nicole C.
Publisher: name: AgResearch
Year: 2023
Subjects: Agricultural, veterinary and food sciences

description: The milk fat globule membrane (MFGM) appears to play an important role in infant neurocognitive development; however, its mechanism(s) of action remains unclear. This study aimed to investigate the role of a dietary MFGM supplement on the lipid profiles of different neonatal brain regions. Ten-day-old male piglets (4–5 kg) were fed unsupplemented infant formula (control, n = 7) or an infant formula supplemented with low (4%) or high (8%) levels of MFGM (n = 8 each) daily for 21 days. Piglets were then euthanized, and brain tissues were sectioned. Untargeted liquid chromatography-mass spectrometry lipidomics was performed on the cerebellum, hippocampus, prefrontal cortex, and the rest of the brain. The analyses identified 271 and 171 lipids using positive and negative ionization modes, respectively, spanning 16 different lipid classes. MFGM consumption did not significantly alter the lipidome in most brain regions, regardless of dose, compared to the control infant formula. However, 16 triacylglyceride species were increased in the hippocampus (t-test, p-value < 0.05) of the high-supplemented piglets. Most lipids (262 (96.7%) and 160 (93.6%), respectively) differed significantly between different brain regions (ANOVA, false discovery rate corrected p-value < 0.05) independent of diet. Thus, this study highlighted that dietary MFGM altered lipid abundance in the hippocampus and detected large differences in lipid profiles between neonatal piglet brain regions.
Baryons do trace dark matter 380,000 years after the big bang: Search for compensated isocurvature perturbations with WMAP 9-year data
Creators: name: Grin, Daniel
name: Hanson, Duncan
name: Holder, Gilbert
name: Doré, Olivier
name: Kamionkowski, Marc
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Primordial isocurvature fluctuations between photons and either neutrinos or non-relativistic species such as baryons or dark matter are known to be sub-dominant to adiabatic fluctuations. Perturbations in the relative densities of baryons and dark matter (known as compensated isocurvature perturbations, or CIPs), however, are surprisingly poorly constrained. CIPs leave no imprint in the cosmic microwave background (CMB) on observable scales, at least at linear order in their amplitude and zeroth order in the amplitude of adiabatic perturbations. It is thus not yet empirically known if baryons trace dark matter at the surface of last scattering. If CIPs exist, they would spatially modulate the Silk damping scale and acoustic horizon, causing distinct fluctuations in the CMB temperature/polarization power spectra across the sky: this effect is first order in both the CIP and adiabatic mode amplitudes. Here, temperature data from the Wilkinson Microwave Anisotropy Probe (WMAP) are used to conduct the first CMB-based observational search for CIPs, using off-diagonal correlations and the CMB trispectrum. Reconstruction noise from weak lensing and point sources is shown to be negligible for this data set. No evidence for CIPs is observed, and a 95%-confidence upper limit of $1.1\times 10^{-2}$ is imposed to the amplitude of a scale-invariant CIP power spectrum. This limit agrees with CIP sensitivity forecasts for WMAP, and is competitive with smaller scale constraints from measurements of the baryon fraction in galaxy clusters. It is shown that the root-mean-squared CIP amplitude on 5-100 degree scales is smaller than 0.07-0.17 (depending on the scale) at the 95%-confidence level. Temperature data from the Planck satellite will provide an even more sensitive probe for the existence of CIPs, as will the upcoming ACTPol and SPTPol experiments on smaller angular scales.
description: 16 pages, 6 figures, to be submitted to Phys. Rev. D
Redundancy Allocation of Partitioned Linear Block Codes
Creators: name: Kim, Yongjune
name: Kumar, B. V. K. Vijaya
Publisher: name: arXiv
Year: 2013
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Most memories suffer from both permanent defects and intermittent random errors. The partitioned linear block codes (PLBC) were proposed by Heegard to efficiently mask stuck-at defects and correct random errors. The PLBC have two separate redundancy parts for defects and random errors. In this paper, we investigate the allocation of redundancy between these two parts. The optimal redundancy allocation will be investigated using simulations and the simulation results show that the PLBC can significantly reduce the probability of decoding failure in memory with defects. In addition, we will derive the upper bound on the probability of decoding failure of PLBC and estimate the optimal redundancy allocation using this upper bound. The estimated redundancy allocation matches the optimal redundancy allocation well.
description: 5 pages, 2 figures, to appear in IEEE International Symposium on Information Theory (ISIT), Jul. 2013
Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA
Creators: name: Baldwin, Albert S., Jr.
name: LeBowitz, Jonathan H.
name: Sharp, Phillip A.
name: Singh, Harinder
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: A novel strategy has been used to isolate a cDNA clone that encodes a DNA binding domain whose recognition properties overlap those of the mammalian transcription factors H2TF1 and NF-KB. These two factors are distinguished by their cell type distributions and their relative affinities for related sequence elements in the enhancers of the major histocompatibility complex (MHC) class I and immunoglobulin K chain genes. The human cDNA clone was detected by screening a ~ phage expression library with a binding site probe derived from the MHC enhancer. The phage encoded fusion protein binds specifically to both the MHC and K gene enhancers. The cDNA hybridizes to a single copy gene that is expressed as a 10 kb mRNA in both B and non-B cells. The strategy used in this study may prove generally useful in the cloning and analysis of sequence-specific DNA binding proteins.
EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation
Creators: name: Magnuson, Terry
name: Mu, Weipeng
name: Yee, Della
name: Starmer, Joshua
Publisher: name: BioMed Central
Year: 2018

description: Abstract
                Background
                Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resulting in differential gene regulation. However, it remains unknown how PRC2 specifies the degree and biological effects of H3K27 methylation within a given cellular context. One way to determine PRC2 specificity may be through alternative splicing of Ezh2, PRC2’s catalytic subunit, during cell differentiation and tissue maturation.
                Results
                We fully characterized the alternative splicing of Ezh2 in somatic cells and male germ cells and found that Ezh’s exon 14 was differentially regulated during mitosis and meiosis. The Ezh2 isoform containing exon 14 (ex14-Ezh2) is upregulated during cell cycle progression, consistent with a role in maintaining H3K27 methylation during chromatin replication. In contrast, the isoform lacking exon 14 (ex14D-Ezh2) was almost exclusively present in spermatocytes when new H3K27me2 is established during meiotic differentiation. Moreover, Ezh2’s transcript is normally controlled by E2F transcription activators, but in spermatocytes, Ezh2’s transcription is controlled by the meiotic regulator MYBL1. Compared to ex14-EZH2, ex14D-EZH2 has a diminished efficiency for catalyzing H3K27me3 and promotes embryonic stem cell differentiation.
                Conclusions
                Ezh2’s expression is regulated at transcriptional and post-transcriptional levels in a cellular context-dependent manner. EZH2 variants determine functional specificity of PRC2 in histone methylation during cell proliferation and differentiation.
Particle swarming of sensor correction filters
Creators: name: Carter, Johnathan J.
name: Cooper, Samuel J.
name: Thrift, Edward
name: Briggs, Joseph
name: Warner, Jim
name: Ross, Michael P.
name: Mow-Lowry, Conor M.
Publisher: name: Bristol : Institute of Physics Publ. (IOP)
Year: 2020
Subjects: subject: particle swarm
subject: seismic isolation
subject: sensor correction
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Reducing the impact of seismic activity on the motion of suspended optics is essential for the operation of ground-based gravitational wave detectors. During periods of increased seismic activity, low-frequency ground translation and tilt cause the Advanced LIGO observatories to lose 'lock', reducing their duty cycles. This paper applies modern global-optimisation algorithms to aid in the design of the 'sensor correction' filter, used in the control of the active platforms. It is shown that a particle swarm algorithm that minimises a cost-function approximating the differential root mean squared velocity between platforms can produce control filters that perform better across most frequencies in the control bandwidth than those currently installed. These tests were conducted using training data from the LIGO Hanford Observatory seismic instruments and simulations of the Horizontal Access Module Internal Seismic Isolation platforms. These results show that new methods of producing control filters are ready for use at LIGO. The filters were implemented at LIGO's Hanford Observatory, and use the resulting data to refine the cost function. © 2020 IOP Publishing Ltd Printed in the UK
Personality preference influences medical student use of specific computer-aided instruction (CAI)
Creators: name: Mendez, Michelle
name: McNulty, John A
name: Halsey, Martha
name: Espiritu, Baltazar
Publisher: name: BioMed Central Ltd
Year: 2006

description: Abstract Background The objective of this study was to test the hypothesis that personality preference, which can be related to learning style, influences individual utilization of CAI applications developed specifically for the undergraduate medical curriculum. Methods Personality preferences of students were obtained using the Myers-Briggs Type Indicator (MBTI) test. CAI utilization for individual students was collected from entry logs for two different web-based applications (a discussion forum and a tutorial) used in the basic science course on human anatomy. Individual login data were sorted by personality preference and the data statistically analyzed by 2-way mixed ANOVA and correlation. Results There was a wide discrepancy in the level and pattern of student use of both CAI. Although individual use of both CAI was positively correlated irrespective of MBTI preference, students with a "Sensing" preference tended to use both CAI applications more than the "iNtuitives". Differences in the level of use of these CAI applications (i.e., higher use of discussion forum vs. a tutorial) were also found for the "Perceiving/Judging" dimension. Conclusion We conclude that personality/learning preferences of individual students influence their use of CAI in the medical curriculum.
Program study for the New York State Chamber of Commerce, Committee on Lower Manhattan Redevelopment, January 28, 1957
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1957
Subjects: City planning--New York (State)--New York.
Urban renewal--New York (State)--New York.

description: "This report presents the results of a study made for the Committee on Lower Manhattan Redevelopment of the New York Chamber of Commerce for the purpose of recommending: (a) the appropriate scope of the Committee's functions; (b) the general outline of a program of activities for the performance of these functions; (c) the composition of staff and size of budget necessary to conduct such a program."
Improving accuracy of quantifying nitrate removal performance and enhancing understanding of processes in woodchip bioreactors using high-frequency data
Creators: name: Rivas, A.
name: Barkle, G.
name: Sarris, Theo
name: Park, J.
name: Kenny, A.
name: Maxwell, B.
name: Stenger, R.
name: Moorhead, B.
name: Schipper, L.
name: Clague, J.
Publisher: name: Institute of Environmental Science and Research
Year: 2023
Subjects: Pollution and contamination not elsewhere classified

description: Woodchip bioreactors have gained popularity in many countries as a conservation practice for reducing nitrate load to freshwater. However, current methods for assessing their performance may be inadequate when nitrate removal rates (RR) are determined from low-frequency (e.g., weekly) concurrent sampling at the inlet and outlet. We hypothesised that high-frequency monitoring data at multiple locations can help improve the accuracy of quantifying nitrate removal performance, enhance the understanding of processes occurring within a bioreactor, and therefore improve the design practice for bioreactors. Accordingly, the objectives of this study were to compare RRs calculated using high- and low-frequency sampling and assess the spatiotemporal variability of the nitrate removal within a bioreactor to unravel the processes occurring within a bioreactor. For two drainage seasons, we monitored nitrate concentrations at 21 locations on an hourly or two-hourly basis within a pilot-scale woodchip bioreactor in Tatuanui, New Zealand. A novel method was developed to account for the variable lag time between entry and exit of a parcel of sampled drainage water. Our results showed that this method not only enabled lag time to be accounted for but also helped quantify volumetric inefficiencies (e.g., dead zone) within the bioreactor. The average RR calculated using this method was significantly higher than the average RR calculated using conventional low-frequency methods. The average RRs of each of the quarter sections within the bioreactor were found to be different. 1-D transport modelling confirmed the effect of nitrate loading on the removal process as nitrate reduction followed Michaelis-Menten (MM) kinetics.
Five degrees of freedom test mass readout via optical levers
Creators: name: Huarcaya, V.
name: Apelbaum, G.
name: Haendchen, V.
name: Wang, Q.
name: Heinzel, G.
name: Mehmet, M.
Publisher: name: Bristol : Institute of Physics Publ. (IOP)
Year: 2020
Subjects: subject: optical lever
subject: precision measurement
subject: test mass readout
subject: torsion pendulum
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: High precision measurement of all six degrees of freedom of freely floating test masses is necessary for future gravitational space missions as the sensing noise is frequently a limiting factor in the overall performance of the instrument. Femto-meter sensitivity has been demonstrated with LISA Pathfinder which used a complex laser interferometric setup. However, these measurements where restricted to the length changes in one degree of freedom only. When aiming for sensing multiple degrees of freedom, typically capacitive sensing is used, which facilitates a compact setup but does not provide competitive precision. An alternative approach to improve the sensitivity beyond capacitance readout systems and to reduce the complexity of the setup, is to use optical levers. Here, we report on the realization of a test mass sensing system by means of a modulation/demodulation technique in combination with four optical levers detected by quadrant photodiodes. The results of our table-top experiment show that this configuration allows us to extract information on five degrees of freedom of a cubic test mass. With basic off-the-shelf laser diodes we demonstrate an angular resolution of below 600 nrad Hz-1/2 at frequencies between 10 mHz and 1 Hz (which is better than a conventional autocollimator) while simultaneously measuring the linear motion of the test mass with a precision of better than 300 nm Hz-1/2 in the same frequency band. Extension of the geometry will enable optical sensing of all six degrees of freedom of the test mass. © 2019 IOP Publishing Ltd.
Detecting Baryon Acoustic Oscillations with Third-generation Gravitational Wave Observatories
Creators: name: Kumar, Sumit
name: Vijaykumar, Aditya
name: Nitz, Alexander H.
Publisher: name: London : Institute of Physics Publ.
Year: 2022
Subjects: subject: Hubble Constant
subject: Binary Mergers
subject: Advanced Ligo
subject: Scale
subject: Propagation
subject: Coalescence
subject: Cosmology
subject: Universe
subject: Objects
subject: Virgo
subject: Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie

description: We explore the possibility of detecting baryon acoustic oscillations (BAO) solely from gravitational wave (GW) observations of binary neutron star mergers with third-generation (3G) GW detectors such as the Cosmic Explorer and the Einstein Telescope. These measurements would provide a new independent probe of cosmology. The detection of the BAO peak with current-generation GW detectors (solely from GW observations) is not possible because i) unlike galaxies, the GW mergers are poorly localized, and ii) there are not enough merger events to probe the BAO length scale. With the 3G GW detector network, it is possible to observe 1/4 (1000) binary neutron star mergers per year that are localized well within one square degree in the sky for redshift z ≤ 0.3. We show that 3G observatories will enable precision measurements of the BAO feature in the large-scale two-point correlation function; the effect of BAO can be independently detected at different redshifts, with a log-evidence ratio of 1/423, 17, or 3, favoring a model with a BAO peak at redshift of 0.2, 0.25, or 0.3, respectively, using a redshift bin corresponding to a shell of thickness 150h -1 Mpc. © 2022. The Author(s). Published by the American Astronomical Society.
Spasskylepis Schaldybin 1964
Creators: name: Kornienko, Svetlana A.
name: Binkienė, Rasa
name: Dokuchaev, Nikolai E.
name: Tkach, Vasyl V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Cestoda
Cyclophyllidea
Hymenolepididae
Spasskylepis

description: SPASSKYLEPIS SCHALDYBIN, 1964
Amended diagnosis (modified after Gulyaev et al., 2004): Small cestodes with serial homonomous maturation. Strobila can consist of one to four series of proglottides. Proglottides slightly craspedote, young wider than long, gravid longer than wide. Scolex with rudimentary rostellum. Suckers elongate, inside dorsal andventralbothrium-likedepressions.Osmoregulatory canals without transverse anastomoses. Genital pores dextral. Testes three, in a triangle, one poral and two antiporal. Cirrus-sac crosses midline of proglottis. Cirrus armed, internal seminal vesicle absent, external seminal vesicle elongate. Ovary trilobed. Vitellarium entire, postovarian. Seminal receptacle indistinct. Uterus sacciform. Holarctic.
Type species: Spasskylepis ovaluteri Schaldybin, 1964 (syn.: Spasskylepis pheodorovi Karpenko, 1984).
Other species: Spasskylepis tiunovi Lykova, Mel'nikova & Karpenko, 2005; Spasskylepis rauschi Gulyaev, Dokuchaev & Lykova, 2010.
Remarks: Spasskylepis ovaluteri is morphologically similar to Ditestolepis diaphana (Fig. 3A, D), therefore S. ovaluteri was often misidentified as D. diaphana (Vaucher, 1971; Genov, 1984; Haukisalmi, 1989; Gulyaev, 1991). Gulyaev et al. (2004) redescribed S. ovaluteri and restored the validity of the genus Spasskylepis, which was later confirmed by molecular phylogeny (Haukisalmi et al., 2010). One of the main differences between species of Ditestolepis and Spasskylepis is the uterus development. The uterus of D. diaphana transforms from initially horseshoe-shaped into sacciform, while the uterus of S. ovaluteri is sacciform from the very beginning of its development (Fig. 4G).
description: Published as part of Kornienko, Svetlana A., Binkienė, Rasa, Dokuchaev, Nikolai E. & Tkach, Vasyl V., 2019, Molecular phylogeny and systematics of cestodes with rudimentary rostellum (Cestoda: Hymenolepididae) from Holarctic Sorex shews (Eulipotyphla: Soricidae), pp. 965-986 in Zoological Journal of the Linnean Society 187 on page 981
Agonist-receptor efficacy II: agonist trafficking of receptor signals
Creators: name: Kenakin, Terry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: There is evidence to suggest that receptors with seven transmembrane domains can exist in G protein-activating conformations. It is not known how many activated receptor forms exist for each receptor. Furthermore, if there are multiple forms, does the chemical structure of the agonist determine which form dominates, and therefore, which response pathway is activated? This latter scheme is referred to as agonist-receptor trafficking, and is discussed in this, the second of two articles by Terry Kenakin. One way to approach these questions is to study receptors that couple to more than one G protein and, in essence, to try to allow the G protein to indicate the receptor state.
Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network
Creators: name: Perou, Charles
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYCamplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in METmRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.
title: Oliver Rück, Neue Aspekte und Modelle in der Siedlungsforschung zur Bandkeramik. Die Siedlung Weisweiler 111 auf der Aldenhovener Platte, Kr[eis] Düren
Creators: name: Velde, Pieter Van De
Publisher: name: University Library Heidelberg
Year: 2016

description: Rezension zu: Oliver Rück, Neue Aspekte und Modelle in der Siedlungsforschung zur Bandkeramik. Die Siedlung Weisweiler 111 auf der Aldenhovener Platte, Kr[eis] Düren. Publisher Marie Leidorf, Rahden 2007. 318 pages, 158 figures, 82 tables, 1 list, 17 plates.
Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes
Creators: name: Frampton, James E.
Publisher: name: Adis Journals
Year: 2023
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest James E. Frampton s a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable Additional information about this Adis Drug Review can be found here Abstract Fenfluramine (Fintepla®) is an oral anti-seizure medication (ASM) with a novel mechanism of action consisting of activity in the serotonergic system coupled with positive allosteric modulation effects at sigma-1 receptors. Originally approved for use at high doses as an appetite suppressant, it was subsequently withdrawn after being linked to valvular heart disease (VHD) and pulmonary arterial hypertension (PAH), before being investigated for use at low doses as an adjunctive ASM in patients with developmental epileptic encephalopathies, including Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) who have pharmacoresistant seizures. In clinical trials, treatment with adjunctive fenfluramine markedly reduced convulsive seizure frequency in patients with DS that were sustained for up to 3 years, and reduced drop seizure frequency in patients with LGS that were sustained for up to 1 year. Notably, fenfluramine was also associated with clinically meaningful improvements in aspects of everyday executive functioning (EF) not entirely explainable by seizure reduction alone. Furthermore, it was generally well tolerated with, importantly, no reports of VHD or PAH. Thus, adjunctive fenfluramine is a novel and effective treatment for pharmacoresistant seizures associated with DS and LGS that may also improve aspects of everyday EF in some patients
Feasibility of the finite amplitude method in covariant density functional theory
Creators: name: Liang, Haozhao
name: Nakatsukasa, Takashi
name: Niu, Zhongming
name: Meng, Jie
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Self-consistent relativistic random-phase approximation (RPA) in the radial coordinate representation is established by using the finite amplitude method (FAM). Taking the isoscalar giant monopole resonance in spherical nuclei as example, the feasibility of the FAM for the covariant density functionals is demonstrated, and the newly developed methods are verified by the conventional RPA calculations. In the present relativistic RPA calculations, the effects of the Dirac sea can be automatically taken into account in the coordinate-space representation. The rearrangement terms due to the density-dependent couplings can be implicitly calculated without extra computational costs in both iterative and matrix FAM schemes.
description: 12 pages, 5 figures
Correction to: Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
Creators: name: Mwandagalirwa, Melchior K
name: Tshefu, Antoinette
name: Janko, Mark
name: Carrel, Margaret
name: Meshnick, Steven R.
name: Levitz, Lauren
name: Goel, Varun
name: Thwai, Kyaw L
name: Parr, Jonathan B
name: Emch, Michael
Publisher: name: BioMed Central
Year: 2018

description: Unfortunately after publication of the original article [1], it came to the author’s attention that there is an error in the caption of Fig. 2.
Rubus idaeus L.
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: R. idaeus L. Cat. 86. Verbreitet. Bis 2610 m: Hütten der Fluhalp ob Zermatt, mehrere Exemplare, steril (Becherer 1950); etwas niedriger, ebenfalls bei Zermatt: Bahnhof Riffelberg, 2582 m, ein Exemplar, steril (idem 1950).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
title: Christian Frevel und Henner von Hesberg (Hrsg.), Kult und Kommunikation. Medien in Heiligtümern der Antike
Creators: name: Mylonopoulos, Ioannis
Publisher: name: University Library Heidelberg
Year: 2016

description: Rezension zu: Christian Frevel und Henner von Hesberg (Hrsg.), Kult und Kommunikation. Medien in Heiligtümern der Antike. Schriften des Lehr- und Forschungszentrums für die antiken Kulturen des Mittelmeerraumes 4. Verlag Dr. Ludwig Reichert, Wiesbaden 2007. 468 Seiten, 116 Abbildungen.
$α$ Centauri A in the far infrared
Creators: name: Liseau, R.
name: Montesinos, B.
name: Olofsson, G.
name: Bryden, G.
name: Marshall, J. P.
name: Ardila, D.
name: Aran, A. Bayo
name: Danchi, W. C.
name: del Burgo, C.
name: Eiroa, C.
name: Ertel, S.
name: Fridlund, M. C. W.
name: Krivov, A. V.
name: Pilbratt, G. L.
name: Roberge, A.
name: Thébault, P.
name: Wiegert, J.
name: White, G. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Chromospheres and coronae are common phenomena on solar-type stars. Understanding the energy transfer to these heated atmospheric layers requires direct access to the relevant empirical data. Study of these structures has, by and large, been limited to the Sun thus far. The region of the temperature reversal can be directly observed only in the far infrared and submm. We aim at the determination of the characteristics of the atmosphere in the region of the temperature minimum of the solar sister star alpha Cen A. For the nearby binary system alpha Centauri, stellar parameters are known with high accuracy from measurements. For the basic model parameters Teff, log g and [Fe/H], we interpolate in the grid of GAIA/PHOENIX stellar model atmospheres and compute the corresponding model for the G2 V star alpha Cen A. Comparison with photometric measurements shows excellent agreement between observed photospheric data in the optical and infrared. For longer wavelengths, the modelled spectral energy distribution is compared to MIPS, PACS, SPIRE and LABOCA photometry. A specifically tailored Uppsala model based on the MARCS code and extending further in wavelength is used to gauge the emission characteristics of alpha Cen A in the FIR. Similar to the Sun, the FIR emission of alpha Cen A originates in the minimum temperature region above the stellar photosphere in the visible. However, in comparison with the solar case, the FIR photosphere of alpha Cen A appears marginally cooler, Tmin=T160mu=3920+/-375 K. Beyond the minimum near 160mu, the brightness temperatures increase and this radiation likely originates in warmer regions of the chromosphere of alpha Cen A. To the best of our knowledge this is the first time a temperature minimum has been directly measured on a main-sequence star other than the Sun.
description: 5 pages, 1 figure, A&A Letters, in press
Genome-wide association study of lung function and clinical implication in heavy smokers
Creators: name: Hawkins, Gregory A
name: Christenson, Stephanie A
name: Woodruff, Prescott G
name: Hoffman, Eric A
name: Li, Xingnan
name: Dransfield, Mark T
name: Kanner, Richard E
name: Ortega, Victor E
name: Couper, David
name: Kleerup, Eric C
name: Graham Barr, R.
name: Paine, Robert
name: Han, Mei L K
name: Ampleford, Elizabeth J
name: Martinez, Fernando J
name: Hansel, Nadia N
name: Cooper, Christopher B
name: Bleecker, Eugene R
name: Meyers, Deborah A
Publisher: name: BioMed Central
Year: 2018

description: Abstract
                Background
                The aim of this study is to identify genetic loci associated with post-bronchodilator FEV1/FVC and FEV1, and develop a multi-gene predictive model for lung function in COPD.
                Methods
                Genome-wide association study (GWAS) of post-bronchodilator FEV1/FVC and FEV1 was performed in 1645 non-Hispanic White European descent smokers.
                Results
                A functional rare variant in SERPINA1 (rs28929474: Glu342Lys) was significantly associated with post-bronchodilator FEV1/FVC (p = 1.2 × 10− 8) and FEV1 (p = 2.1 × 10− 9). In addition, this variant was associated with COPD (OR = 2.3; p = 7.8 × 10− 4) and severity (OR = 4.1; p = 0.0036). Heterozygous subjects (CT genotype) had significantly lower lung function and higher percentage of COPD and more severe COPD than subjects with the CC genotype. 8.6% of the variance of post-bronchodilator FEV1/FVC can be explained by SNPs in 10 genes with age, sex, and pack-years of cigarette smoking (P <  2.2 × 10− 16).
                Conclusions
                This study is the first to show genome-wide significant association of rs28929474 in SERPINA1 with lung function. Of clinical importance, heterozygotes of rs28929474 (4.7% of subjects) have significantly reduced pulmonary function, demonstrating a major impact in smokers. The multi-gene model is significantly associated with CT-based emphysema and clinical outcome measures of severity. Combining genetic information with demographic and environmental factors will further increase the predictive power for assessing reduced lung function and COPD severity.
title: Max Kunze, Griechische und römische Bronzen. Meisterwerke antiker Bronzen und Metallarbeiten aus der Sammlung Borowski
Creators: name: Klatt, Ute
Publisher: name: University Library Heidelberg
Year: 2016

description: Rezension zu: Max Kunze, Griechische und römische Bronzen. Meisterwerke antiker Bronzen und Metallarbeiten aus der Sammlung Borowski, Band I. Verlag Franz Philipp Rutzen, Ruhpolding und Mainz 2007. 328 Seiten, 447 zumeist farbige Abbildungen, 16 Tabellen.
title: Stefan Groh und Helga Sedlmayer, Forschungen im Vicus Ost von Mautern-Favianis. Die Grabungen der Jahre 1997–1999
Creators: name: Erdrich, Michael
Publisher: name: University Library Heidelberg
Year: 2016

description: Rezension zu: Stefan Groh und Helga Sedlmayer, Forschungen im Vicus Ost von Mautern Favianis. Die Grabungen der Jahre 1997–1999. Mit Beiträgen von Christa Frank, Karl Günther Kunst, Klaus Vondrowec und Reinhold Weding. Verlag der Österreichischen Akademie der Wissenschaften, Wien 2006. Textband 768 Seiten mit 272 Abbildungen, Katalog- und Tafelband 766 Seiten, Beilagenmappe mit 49 zum Teil farbigen Beilagen und einer CD-ROM.
Electroweak Cogenesis
Creators: name: Cheung, Clifford
name: Zhang, Yue
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a simple renormalizable model of baryogenesis and asymmetric dark matter generation at the electroweak phase transition. Our setup utilizes the two Higgs doublet model plus two complex gauge singlets, the lighter of which is stable dark matter. The dark matter is charged under a global symmetry that is broken in the early universe but restored during the electroweak phase transition. Because the ratio of baryon and dark matter asymmetries is controlled by model parameters, the dark matter need not be light. Thus, new force carriers are unnecessary and the symmetric dark matter abundance can be eliminated via Higgs portal interactions alone. Our model places a rough upper bound on the dark matter mass, and has implications for direct detection experiments and particle colliders.
description: 9 pages, 4 figures
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
Creators: name: Flood, Patrick M.
name: Wilson, Belinda
name: Xu, Zongli
name: Qian, Li
name: Hong, Jau-Shyong
name: Zhang, Wei
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background The mechanisms involved in the induction and regulation of inflammation resulting in dopaminergic (DA) neurotoxicity in Parkinson's disease (PD) are complex and incompletely understood. Microglia-mediated inflammation has recently been implicated as a critical mechanism responsible for progressive neurodegeneration. Methods Mesencephalic neuron-glia cultures and reconstituted cultures were used to investigate the molecular mechanisms of sinomenine (SN)-mediated anti-inflammatory and neuroprotective effects in both the lipopolysaccharide (LPS)- and the 1-methyl-4-phenylpyridinium (MPP+)-mediated models of PD. Results SN showed equivalent efficacy in protecting against DA neuron death in rat midbrain neuron-glial cultures at both micro- and sub-picomolar concentrations, but no protection was seen at nanomolar concentrations. The neuroprotective effect of SN was attributed to inhibition of microglial activation, since SN significantly decreased tumor necrosis factor-α (TNF-α, prostaglandin E2 (PGE2) and reactive oxygen species (ROS) production by microglia. In addition, from the therapeutic point of view, we focused on sub-picomolar concentration of SN for further mechanistic studies. We found that 10-14 M of SN failed to protect DA neurons against MPP+-induced toxicity in the absence of microglia. More importantly, SN failed to show a protective effect in neuron-glia cultures from mice lacking functional NADPH oxidase (PHOX), a key enzyme for extracellular superoxide production in immune cells. Furthermore, we demonstrated that SN reduced LPS-induced extracellular ROS production through the inhibition of the PHOX cytosolic subunit p47phoxtranslocation to the cell membrane. Conclusion Our findings strongly suggest that the protective effects of SN are most likely mediated through the inhibition of microglial PHOX activity. These findings suggest a novel therapy to treat inflammation-mediated neurodegenerative diseases.
Is Europe Evolving Toward an Integrated Research Area?
Creators: name: Chessa, Alessandro
name: Morescalchi, Andrea
name: Pammolli, Fabio
name: Penner, Orion
name: Petersen, Alexander M.
name: Riccaboni, Massimo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Digital Libraries (cs.DL)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: An integrated European Research Area (ERA) is a critical component for a more competitive and open European R&D system. However, the impact of EU-specific integration policies aimed at overcoming innovation barriers associated with national borders is not well understood. Here we analyze 2.4 x 10^6 patent applications filed with the European Patent Office (EPO) over the 25-year period 1986-2010 along with a sample of 2.6 x 10^5 records from the ISI Web of Science to quantitatively measure the role of borders in international R&D collaboration and mobility. From these data we construct five different networks for each year analyzed: (i) the patent co-inventor network, (ii) the publication co-author network, (iii) the co-applicant patent network, (iv) the patent citation network, and (v) the patent mobility network. We use methods from network science and econometrics to perform a comparative analysis across time and between EU and non-EU countries to determine the "treatment effect" resulting from EU integration policies. Using non-EU countries as a control set, we provide quantitative evidence that, despite decades of efforts to build a European Research Area, there has been little integration above global trends in patenting and publication. This analysis provides concrete evidence that Europe remains a collection of national innovation systems.
description: 24 pages, 4 figures, 2 tables
title: Cusps and $q$-Expansion Principles for Modular Curves at Infinite Level
Creators: name: Heuer, Ben
Publisher: name: Deutsche Mathematiker-Vereinigung
Year: 2022

description: We develop an analytic theory of cusps for Scholze's \mbox{$p$-adic} modular curves at infinite level in terms of perfectoid parameter spaces for Tate curves. As an application, we describe a canonical tilting isomorphism between an anticanonical overconvergent neighbourhood of the ordinary locus of the modular curve at level $\Gamma_1(p^\infty)$ and the analogous locus of an infinite level perfected Igusa variety. We also prove various $q$-expansion principles for functions on modular curves at infinite level, namely that the properties of extending to the cusps, vanishing, coming from finite level, and being bounded, can all be detected on $q$-expansions.
description: DOCUMENTA MATHEMATICA, Vol 27 (2022), p. 2385-2439
Feedback-cooling of an atomic spin ensemble
Creators: name: Behbood, N.
name: Napolitano, M.
name: Colangelo, G.
name: Ciurana, F. Martin
name: Sewell, R. J.
name: 1
name: Mitchell, M. W.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We describe a measurement-and-feedback technique to deterministically prepare low-entropy states of atomic spin ensembles. Using quantum non-demolition measurement and incoherent optical feedback, we drive arbitrary states in the spin-orientation space toward the origin of the spin space. We observe 12 dB of spin noise reduction, or a factor of 63 reduction in phase-space volume. We find optimal feedback conditions and show that multi-stage feedback is advantageous. An input-output calculation of quantum noise incorporating realistic quantum noise sources and experimental limitations agrees well with the observations. The method may have application to generation of exotic phases of ultracold gases, for example macroscopic singlet states and valence-bond solids.
description: 4 figures
Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium
Creators: name: Beeh, Kai-Michael
name: Donohue, James F
name: Beier, Jutta
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Randomised, double-blind, controlled trials are considered the gold standard for evaluating a pharmacological agent, as they minimise any potential bias. However, it is not always possible to perform double-blind trials, particularly for medications delivered via specific devices, e.g. inhalers. In such cases, open-label studies can be employed instead. Methods used to minimise any potential bias introduced by open-label study design include randomisation, crossover study design, and objective measurements of primary efficacy and safety variables. Concise reviews analysing the effect of blinding procedures of comparator drugs on outcomes in respiratory trials are limited. Here, we compare data from different chronic obstructive pulmonary disease trials with once-daily indacaterol versus a blinded or non-blinded comparator. The clinical trial programme for indacaterol, a once-daily, long-acting β2-agonist, used tiotropium as a comparator either in an open-label or blinded fashion. Data from these studies showed that the effects of tiotropium were consistent for forced expiratory volume in 1 second, an objective measure, across blinded and non-blinded studies. The data were consistent with previous studies of double-blind tiotropium, suggesting that the open-label use of tiotropium did not introduce treatment bias. The effect of tiotropium on subjective measures (St George’s Respiratory Questionnaire; transition dyspnoea index) varied slightly across blinded and non-blinded studies, indicating that minimal bias was introduced by using open-label tiotropium. Importantly, the studies used randomised, open-label tiotropium patients to treatment allocation, a method shown to minimise bias to a greater degree than blinding. In conclusion, it is important when reporting a clinical trial to be transparent about who was blinded and how the blinding was performed; if the design is open-label, additional efforts must be made to minimise risk of bias. If these recommendations are followed, and the data are considered in the full knowledge of any potential sources of bias, results with tiotropium suggest that data from open-label studies can provide valuable and credible evidence of the effects of therapy.
E_1-Formality of Complex Algebraic Varieties
Creators: name: Cirici, J.
name: Guillén, F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55P62, 32S35

description: Let X be a smooth complex algebraic variety. Morgan [Mor78] showed that the rational homotopy type of X is a formal consequence of the differential graded algebra defined by the first term of its weight spectral sequence. In the present work we generalize this result to arbitrary nilpotent complex algebraic varieties (possibly singular and/or non-compact) and to algebraic morphisms between them. The result for algebraic morphisms generalizes the Formality Theorem of [DGMS75] for compact Kähler varieties, filling a gap in Morgan's theory concerning functoriality over the rational numbers. As an application, we study the Hopf invariant of certain algebraic morphisms using intersection theory.
Supplementary document for Maximum-likelihood estimation in ptychography in the presence of Poisson-Gaussian noise statistics - 6665153.pdf
Creators: name: Seifert, Jacob
name: Shao, Yifeng
name: van Dam, Rens
name: Bouchet, Dorian
name: van Leeuwen, Tristan
name: Mosk, Allard
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental document