cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lasioglossum (Dialictus) duckei
Creators: name: Astafurova, Yu. V.
name: Proshchalykin, M. Yu.
name: Maharramov, M. M.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Halictidae
Lasioglossum
Lasioglossum duckei

description: Lasioglossum (Dialictus) duckei (Alfken, 1909)
MATERIAL EXAMINED. Azerbaijan: Nakhchivan Autonomous Republic: Ordubad, Bilav-1, 1050 m, 39°02′N 45°49′E, 20.VI 2024, 1 ♂.
DISTRIBUTION. Caucasus: * Azerbaijan, Armenia. – South Eastern Europe from Eastern Italy and the Balkans to the Don River in the East; Crete [ssp. psiloritum Ebmer, 1981]; Turkey [ssp. hakkariensis (Warncke, 1984)] (Ebmer, 1988, 2014).
description: Published as part of Astafurova, Yu. V., Proshchalykin, M. Yu. & Maharramov, M. M., 2024, A NEW SPECIES AND NEW RECORDS OF LASIOGLOSSUM CURTIS (HYMENOPTERA, HALICTIDAE) FROM AZERBAIJAN, pp. 1-9 in Far Eastern Entomologist 513 on page 7, DOI: 10.25221/fee.513.1, http://zenodo.org/record/14659101
Liolaemus kriegi Muller & Hellmich 1939
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus kriegi

description: Liolaemus kriegi Müller & Hellmich
Liolaemus kriegi Müller & Hellmich 1939b: 44 (type locality: Bariloche, Argentina); Hellmich 1960: 39; Donoso-Barros 1966a: 289, 1970a: 183, 1970b: 92, 1974a: 287; Daciuk 1968: 275; Péfaur & Duellman 1980: 45; Cei 1986: 230; Vanzolini 1986: 15; Laurent 1992: 31; Núñez & Jaksic 1992: 73; Etheridge 1995: 33; Cruz et al. 1999: 182; Etheridge & Espinoza 2000: 6; Lobo 2001: 139; Pincheira-Donoso 2001: 10; Avila et al. 2003: 534; Chebez et al. 2005: 32; Scolaro 2005: 40; Sura 2005: 40; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) kriegi Pincheira-Donoso & Núñez 2005: 289.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 25, DOI: 10.5281/zenodo.6789337
IL-7/IL-7Ra-Fc Modulation of Immune Responses in Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer death in the United States. The American Cancer Society estimates that lung cancer will be responsible for approximately 161,840 deaths in the United States during 2008. Epidemiological studies show a strong correlation between tobacco smoking and lung cancer. Approximately 85% of all lung cancers occur in current or former cigarette smokers. In the US, there are currently fifty million smokers and fifty million former smokers. Thus, approximately one third of the US population is at high risk for this disease. According to Cancer Facts and Figures 2008, tobacco use accounts for at least 30% of all cancer deaths and 87% of all lung cancer deaths. With the existing therapeutic efforts, the long term survival for lung cancer patients remains low with only 15% surviving for 5 years following diagnosis. Therefore, new therapeutic strategies are clearly needed. One such approach would be to develop immune therapy for lung cancer. Immune approaches remain attractive because although surgery, chemotherapy, and radiotherapy alone or in combination produce high response rates in all histological types of lung cancer, relapse is unavoidable. Thus, strategies to harness the immune system to react against the tumors could be utilized in a combined approach with novel agents or existing forms of therapy for more effective tumor control and long term cancer free survival. In this proposal we will study how lung cancer cells escape from the immune cells and how a protein called interleukin 7/interleukin 7 receptor alpha-Fc activate the immune cells of our body to fight lung cancer. The results of our findings could help develop therapy against lung cancer.
MOESM7 of Comparative characterization of all cellulosomal cellulases from Clostridium thermocellum reveals high diversity in endoglucanase product formation essential for complex activity
Creators: name: Leis, Benedikt
name: Held, Claudia
name: Bergkemper, Fabian
name: Dennemarck, Katharina
name: Steinbauer, Robert
name: Reiter, Alarich
name: Mechelke, Matthias
name: Moerch, Matthias
name: Graubner, Sigrid
name: Liebl, Wolfgang
name: Schwarz, Wolfgang
name: Zverlov, Vladimir
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Additional file 7. Â Molecular docking of cellohexaose in the catalytic cleft of selected cellulosomal cellulases.
Probabilistic photonic computing with chaotic light
Creators: name: Frank Brückerhoff-Plückelmann
name: Hendrik Borras
name: Bernhard Klein
name: Akhil Varri
name: Marlon Becker
name: Jelle Dijkstra
name: Martin Brückerhoff
name: C. David Wright
name: Martin Salinga
name: Harish Bhaskaran
name: Benjamin Risse
name: Holger Fröning
name: Wolfram Pernice
Publisher: name: Zenodo
Year: 2025

description: Biological neural networks effortlessly tackle complex computational problems and excel at predicting outcomes from noisy, incomplete data. Artificial neural networks (ANNs), inspired by these biological counterparts, have emerged as powerful tools for deciphering intricate data patterns and making predictions. However, conventional ANNs can be viewed as “point estimates” that do not capture the uncertainty of prediction, which is an inherently probabilistic process. In contrast, treating an ANN as a probabilistic model derived via Bayesian inference poses significant challenges for conventional deterministic computing architectures. Here, we use chaotic light in combination with incoherent photonic data processing to enable high-speed probabilistic computation and uncertainty quantification. We exploit the photonic probabilistic architecture to simultaneously perform image classification and uncertainty prediction via a Bayesian neural network. Our prototype demonstrates the seamless cointegration of a physical entropy source and a computational architecture that enables ultrafast probabilistic computation by parallel sampling.
Henosepilachna blanchardi Fauvel
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Henosepilachna
Henosepilachna blanchardi

description: Henosepilachna blanchardi (Fauvel)
Epilachna blanchardi Fauvel, 1862: 175.
Henosepilachna blanchardi: Bielawski 1972: 560.
Bielawski (1963, 1972) redescribed this endemic species. This taxon has been cited from Canala (east coast) and from the west coast (Nouméa to Koné). There are no host plant records in the literature.
Material examined. NEW CALEDONIA: Mt Rembai, 1921. i.1977 (J. Balogh rec.) (ONNC). Literature records. NEW CALEDONIA: Nouméa, à Koné (Delauney rec.) (coll. A. Fauvel in IRSNB); Kanala (coll. A. Fauvel in IRSNB) (Bielawski 1972).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 314, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Thinophilus hardyi
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Thinophilus
Thinophilus hardyi

description: hardyi (Tenorio) (S.A. Marshall pers. comm.).
Leptocera hardyi Tenorio, 1967: 427.
Distribution. Introduced. Neotropical, Hawaii; Galápagos: Isabela, San Cristóbal, Santa Cruz, Santiago.
Remarks. Adults of this species were collected primarily from the upper humid zone.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 54, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Spelunconiscus castroi Campos-Filho, Araujo and Taiti 2014
Creators: name: Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Styloniscidae
Spelunconiscus
Spelunconiscus castroi

description: 12. Spelunconiscus castroi Campos-Filho, Araujo and Taiti, 2014
Spelunconiscus castroi Campos-Filho, Araujo and Taiti, in Campos-Filho et al., 2014: 368, figs. 5–8, 40. – Campos-Filho et al., 2016: 2. – Angarten et al., 2017: 17. – Bastos-Pereira et al., 2017: 292. – Campos-Filho et al., 2017b: 70. – Cavalcanti, 2017: 50, Tab. 2. – Gallão and Bichuette, 2018: 7, Tab. 1. – Silva et al., 2018: 56.
Distribution. Troglobitic and amphibious species endemic to Gruta MOC-32 cave, Matozinhos, state of Minas Gerais (Campos-Filho et al., 2014).
description: Published as part of Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio, 2018, Catalogue of terrestrial isopods (Crustacea, Isopoda, Oniscidea) from Brazil: an update with some considerations, pp. 1-40 in Nauplius (e 2018038) (e 2018038) 26 on page 4, DOI: 10.1590/2358-2936e2018038, http://zenodo.org/record/14666839
Liolaemus lemniscatus Gravenhorst 1838
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus lemniscatus

description: Liolaemus lemniscatus Gravenhorst
Liolaemus lemniscatus Gravenhorst 1838: 731 (type locality: Valparaiso, Valparaíso Region, Chile); Boulenger 1885a: 143; Koslowsky 1896: 449, 1898: 171; Quijada 1916: 8; Burt & Burt 1930: 16, 1931: 274, 1933: 33; Hellmich 1934: 29; Donoso-Barros & Candiani 1950: 486; Donoso-Barros 1966a: 191, 1970a: 183, 1970b: 92; Webb & Greer 1969: 193; Jaksic & Núñez 1979: 119; Jaksic et al. 1979, 1980; Christie 1984a: 526; Cei 1986: 260; Vanzolini 1986: 15; Veloso & Navarro 1988: 505; Brygoo 1989: 71; Lamborot & Alvarez-Sarret 1989: 393; Laurent 1992: 32; Núñez & Jaksic 1992: 73; Müller 1994: 35; Etheridge 1995: 33; Etheridge & Espinoza 2000: 6; Escobar et al. 2001: 1679; Lobo 2001: 139; Fox & Shipman 2003: 321; Pincheira-Donoso 2004b: 11; Chebez et al. 2005: 32; Sura 2005: 429; Díaz & Lobo 2006: 265; Scolaro 2006: 38.
Liolaemus hieroglyphicus Gravenhorst 1838: 732 (synonym fide Boulenger 1885a).
Liolaemus (Liolaemus) elegans Tschudi 1845: 157 (synonym fide Roux 1907).
Leiodera gracilis Gray 1845: 211 (in part).
Proctotretus mosaicus Hombron & Jacquinot 1847: 11 (synonym fide Boulenger 1885a); Guichenot 1848: 26; Duméril & Duméril 1851: 72; Jacquinot & Guichenot 1853: Pl. 2, fig. 1.
Proctotretus femoratus Girard 1854: 227 (synonym fide Boulenger 1885a), 1855: 207.
Liolaemus (Ptychodeira) femorata Girard 1858b: 344.
Liolaemus (Ptychodeira) mosaica Girard 1858b: 349.
Liolaemus elegans Vanzolini 1986: 14 (in part).
Liolaemus (Liolaemus) lemniscatus Pincheira-Donoso & Núñez 2005: 220.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 26, DOI: 10.5281/zenodo.6789337
Lasioglossum (Dialictus) daglariense
Creators: name: Astafurova, Yu. V.
name: Proshchalykin, M. Yu.
name: Maharramov, M. M.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Halictidae
Lasioglossum
Lasioglossum daglariense

description: Lasioglossum (Dialictus) daglariense (Warncke, 1984)
MATERIAL EXAMINED. Azerbaijan: Nakhchivan Autonomous Republic:
Shakhbuz, Shakhbuzkend, 1140 m, 39°23′N 45°32′E, 18.VI 2024, 1 ♂. DISTRIBUTION. * Caucasus: Azerbaijan. – Turkey (Ebmer, 1988).
description: Published as part of Astafurova, Yu. V., Proshchalykin, M. Yu. & Maharramov, M. M., 2024, A NEW SPECIES AND NEW RECORDS OF LASIOGLOSSUM CURTIS (HYMENOPTERA, HALICTIDAE) FROM AZERBAIJAN, pp. 1-9 in Far Eastern Entomologist 513 on page 7, DOI: 10.25221/fee.513.1, http://zenodo.org/record/14659101
Additional file 2: of Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study
Creators: name: Ehmann, Lisa
name: Zoller, Michael
name: Minichmayr, Iris
name: Scharf, Christina
name: Maier, Barbara
name: Schmitt, Maximilian
name: Hartung, Niklas
name: Huisinga, Wilhelm
name: Vogeser, Michael
name: Frey, Lorenz
name: Zander, Johannes
name: Kloft, Charlotte
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Regression model for risk calculation.pdf. (PDF 475 kb)
Rudolfina opuntiae
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Rudolfina
Rudolfina opuntiae

description: opuntiae (Richards)
Leptocera (Trachyopella) opuntiae Richards, 1967b: 531.
Leptocera opuntiae: Linsley 1977: 42 [checklist].
Trachyopella opuntiae: Roháček & Marshall 1986: 14 [remarks]; Paiero & Marshall 2020: 45 [remarks].
Rudolfina opuntiae: Pitkin 1989: 33 [review]; Roháček et al. 2001: 248 [catalogue].
Distribution. Endemic. Galápagos: Pinta.
Remarks. Adults were collected in rotting Opuntia (Richards 1967b). This species has not been recorded since the first record.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 54, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Liolaemus leopardinus Muller & Hellmich 1932
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus leopardinus

description: Liolaemus leopardinus Müller & Hellmich
Liolaemus leopardinus leopardinus Müller & Hellmich 1932a: 308 (type locality: Fierro Carrera, San Francisco River, Cerro El Plomo, 2700 m, Los Andes Range, Metropolitan Region, Chile); Hellmich 1934: 96; Donoso-Barros & Candiani 1950: 489; Donoso-Barros 1966a: 311, 1970a: 184, 1970b: 92; Vanzolini 1986: 15; Veloso & Navarro 1988: 505; Laurent 1992: 32.
Liolaemus leopardinus Núñez & Jaksic 1992: 73; Etheridge 1995: 33; Etheridge & Espinoza 2000: 7; Fox & Shipman 2003: 321; Sura 2005: 429; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) leopardinus Pincheira-Donoso & Núñez 2005: 265.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 26, DOI: 10.5281/zenodo.6789337
Lasioglossum (Hemihalictus) denislucum
Creators: name: Astafurova, Yu. V.
name: Proshchalykin, M. Yu.
name: Maharramov, M. M.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Halictidae
Lasioglossum
Lasioglossum denislucum

description: Lasioglossum (Hemihalictus) denislucum (Strand, 1909)
MATERIAL EXAMINED. Azerbaijan: Nakhchivan Autonomous Republic: Ordubad, Bilav-1, 1050 m, 39°02′N 45°49′E, 20.VI 2024, 1 ♀.
DISTRIBUTION. *Caucasus: Azerbaijan. – Macedonia, Greece, Turkey (Ebmer, 2000).
REMARKS. The records of the species from Ukraine, Russia, Azerbaijan, and Kazakhstan by Blüthgen (1925: 113) belong to Lasioglossum pygmaeum ssp. patulum (see Ebmer, 2000: 414).
description: Published as part of Astafurova, Yu. V., Proshchalykin, M. Yu. & Maharramov, M. M., 2024, A NEW SPECIES AND NEW RECORDS OF LASIOGLOSSUM CURTIS (HYMENOPTERA, HALICTIDAE) FROM AZERBAIJAN, pp. 1-9 in Far Eastern Entomologist 513 on page 7, DOI: 10.25221/fee.513.1, http://zenodo.org/record/14659101
Dettopsomyia formosa Lamb 1914
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Dettopsomyia
Dettopsomyia formosa

description: formosa Lamb (Lehnen et al. unpubl.).
Dettopsomyia formosa Lamb, 1914: 350.
Distribution. Introduced. Cosmopolitan; Galápagos: Santa Cruz.
Remarks. Adults of this species were reared from tortoise dung collected fresh in the agricultural zone (Reserva Pájaro Brujo) on Santa Cruz (Lehnen et al. unpubl.).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 55, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Lasioglossum (Hemihalictus) erraticum
Creators: name: Astafurova, Yu. V.
name: Proshchalykin, M. Yu.
name: Maharramov, M. M.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Halictidae
Lasioglossum
Lasioglossum erraticum

description: Lasioglossum (Hemihalictus) erraticum (Blüthgen, 1931)
MATERIAL EXAMINED. Azerbaijan: Nakhchivan Autonomous Republic: Ordubad, Mazra, 39°03′N, 45°55′E, 1615 m, 16.VI 2024, 1 ♀; Babek, Payiz, 1230 m, 39°26′N, 45°22′E, 25.VI 2024, 3 ♀.
DISTRIBUTION. Caucasus: * Azerbaijan, Georgia. – Greece, Aegean islands to the island of Crete, Cyprus, Turkey (Blüthgen, 1931; Ebmer, 1986, 2014).
description: Published as part of Astafurova, Yu. V., Proshchalykin, M. Yu. & Maharramov, M. M., 2024, A NEW SPECIES AND NEW RECORDS OF LASIOGLOSSUM CURTIS (HYMENOPTERA, HALICTIDAE) FROM AZERBAIJAN, pp. 1-9 in Far Eastern Entomologist 513 on pages 7-8, DOI: 10.25221/fee.513.1, http://zenodo.org/record/14659101
Henosepilachna boisduvali Mulsant
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Henosepilachna
Henosepilachna boisduvali

description: Henosepilachna boisduvali (Mulsant)
Epilachna boisduvali Mulsant, 1850: 765.
Epilachna montrouzieri Fauvel, 1862: 174 —synonymized by Korschefsky 1931: 32. Henosepilachna boisduvali: Li & Cook 1961: 47.
This ladybug is a widely distributed species in South East Asia (from Taiwan, Vietnam, Philippines, Ryukyu Islands, Indonesia, West Timor), but also in Australia, Vanuatu, Fiji Islands and Samoa. In New Caledonia, it is recorded from both coasts of Grande Terre, but also on Loyalty Islands and Isle of Pines (Chazeau, pers. obs.). It may be an accidental introduction. This species is considered as a pest on several plants, especially on Cucurbitaceae (Abe & Matsuda 2000).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 314, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Liolaemus lorenzmuelleri Hellmich 1950
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus lorenzmuelleri

description: Liolaemus lorenzmuelleri Hellmich
Liolaemus lorenzmülleri Hellmich 1950: 144 (type locality: Los Andes of Nueva Elqui, 2300 m, Coquimbo Region, Chile); Donoso-Barros 1966a: 297, 1970b: 93; Veloso & Navarro 1988: 506.
Liolaemus lorenzmuelleri Donoso-Barros 1970a: 185; Vanzolini 1986: 15; Laurent 1992: 32; Núñez & Jaksic 1992: 74; Cortés et al. 1995: 19.
Liolaemus lorenzmulleri Etheridge 1995: 33; Etheridge & Espinoza 2000: 7; Lobo 2001: 139; Sura 2005: 429; Díaz & Lobo 2006: 265.
Liolaemus (Liolaemus) lorenzmuelleri Pincheira-Donoso & Núñez 2005: 326.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 26, DOI: 10.5281/zenodo.6789337
Acquired apoptotic resistance in 3D lung cancer spheroids
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One important reason why cancers fail to respond to clinical treatments such as chemotherapy or radiotherapy is that cancers have a high resistance to apoptotic cell death, a form of programmed cell death. Discovering how cancers resist cell death could lead directly to steps that could bypass these survival defenses and help treatments to be more effective. When cells are studied in the laboratory, they are usually studied in flat 2D monolayers, where many mechanisms of resistance can be studied. However, solid tumors, such as lung, grow as 3D masses. When tumor cells grow into 3D structures, they can acquire an additional level of resistance, described as multicellular resistance. We believe that the study of the resistance acquired by cells in 3D may be valuable in improving clinical treatments. Indeed, acquisition by tumor cells of multicellular resistance may explain many instances in which treatments that are found to be effective in laboratories fail to work in the clinic. Lung cancer has indeed a high degree of resistance to various treatments. We have found effective strategies to induce apoptosis when the cells are grown in monolayers that fail when the cells are grown in small 3D structures called spheroids. We have now found that much of this resistance is located at the level of mitochondria, the main cellular organelle responsible of energetic metabolism.

 Apoptosis is finely regulated by a subset of proteins belonging to the Bcl-2 family which interact with the mitochondria, regulating the stability of its membrane and functions. When sufficient death signals converge on the mitochondria, apoptosis is induced. Bcl-2 family members can be divided in two groups, according to their pro- or anti-apoptotic proteins. Their complex interaction kinetics determine if a cell will undergo apoptosis. One reason that accounts for the acquired apoptotic resistance of cancer cells is an increase of the anti-apoptotic or a decrease of the pro-apoptotic proteins.

 Of great interest, specific blockers of anti-apoptotic proteins are currently available for use in patients. I propose to study the complex patterns of interaction of lung cancer three-dimensional cell cultures to understand how they attain additional apoptotic resistance. By these studies, I hope to identify the situations where the inhibition of anti-apoptotic proteins will be most effective and to find additional therapeutic targets that may be useful to improve current therapies available for lung cancer patients. The use of 3D models in studying multicellular resistance is novel and potentially important. We anticipate that these studies will not only clarify the role of mitochondria in acquire multi-cellular resistance but will also advance the use of spheroids as a more realistic model for studying tumor biology to uncover or to screen for other treatments.
Additional file 2: of Exploring the clinically orientated roles of the general practice receptionist: a systematic review protocol
Creators: name: Burrows, Michael
name: Gale, Nicola
name: Greenfield, Sheila
name: Litchfield, Ian
Publisher: name: Figshare
Year: 2017
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Medline search strategy. (DOCX 15Â kb)
title: Sutera, Jamesbrittenia :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Sutera
Jamesbrittenia

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
Henosepilachna buqueti Montrouzier
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Henosepilachna
Henosepilachna buqueti

description: Henosepilachna buqueti (Montrouzier)
Epilachna buqueti Montrouzier, 1861: 305.
Henosepilachna buqueti: Bielawski 1972: 559.
Bielawski (1963, 1972) added details to the original description by Montrouzier. Bielawski (1963) had also examined a specimen from Fiji Islands. This taxon is widespread in New Caledonia. It has been recorded around Nouméa (Saint-Louis, Forêt de Thi), on the west coast (Nouméa to Koné), Canala, Central Range (Mt Mou, Col d’Amieu), but also in the north (Ouayaguette, Diahot Valley), Belep Islands (type locality: Art Island). Host plants are restricted to wild, adventive Solanaceae, which casts doubt the endemic origin of this species (there are no native Solanaceae in New Caledonia).
Material examined. NEW CALEDONIA: Col d'Amieu, 23.vii.1977 (J. Chazeau rec.) (ONNC); Col d'Amieu, 19.i.1977 (J. Balogh rec.) (ONNC); Col d'Amieu, 29.xi.1983 (J. Chazeau rec.) (ONNC); Forêt de Thi, 22.ii.1957 (ONNC); Forêt de Thi, 19.i.1981 (De Bauwe rec.) (ONNC); Forêt de Thi, 11.iv.1981 (J. Chazeau rec.) (ONNC); Ouayaguette, 610 m, forêt humide, x.1988 (J. Chazeau rec.) (ONNC); Saint-Louis, vii.1964 (ONNC); Saint-Louis, ii.1965 (P. Cochereau rec.) (ONNC); Vallée du Diahot (ONNC).
Literature records. NEW CALEDONIA: Saint-Louis, near Nouméa, ii.1965 (P. Cochereau rec.); Saint-Louis, near Nouméa, 7.vii.1964; Kanala (coll. A. Fauvel in IRSNB); Nouméa, à Koné (Delauney rec.) (coll. A. Fauvel in IRSNB) (Bielawski 1972).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 314, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Drosophila cardini Sturtevant 1916
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila cardini

description: cardini Sturtevant(M. Parchami-Araghi pers. comm.).
Drosophila cardini Sturtevant, 1916: 336.
Distribution. Introduced. Afrotropical, Neotropical, Oriental; Galápagos: Santa Cruz.
Remarks. Adults of this species were recently reared from passionfruit in the Scalesia zone (Los Gemelos), oranges in the littoral zone, and from freshly collected Galápagos tomatoes in the highlands on Santa Cruz (Lehnen et al. unpubl.).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 55, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Androdeloscia escalonai Schmidt and Leistikow 2005
Creators: name: Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Philosciidae
Androdeloscia
Androdeloscia escalonai

description: 25. Androdeloscia escalonai Schmidt and Leistikow, 2005
Androdeloscia escalonai Schmidt and Leistikow,2005: 128, figs. 9–15. – Grangeiro et al., 2017: 375, fig. 7.
Distribution. This species was originally described from Cueva del Viento, Falcón, Venezuela (Schmidt and Leistikow, 2005). In Brazil, it is recorded from Reserva Florestal Adolpho Ducke, Itacoatiara, state of Amazonas (Grangeiro et al., 2017).
description: Published as part of Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio, 2018, Catalogue of terrestrial isopods (Crustacea, Isopoda, Oniscidea) from Brazil: an update with some considerations, pp. 1-40 in Nauplius (e 2018038) (e 2018038) 26 on page 6, DOI: 10.1590/2358-2936e2018038, http://zenodo.org/record/14666839
Breaking Ground on the Moon: Regolith as a Key Component in Lunar Thermal Energy Storage
Creators: name: Marques Sierra, Antonio Luis
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400804
subject: Electrical energy storage

description: Regolith, abundant on the lunar surface, possesses properties that make it an attractive candidate for thermal energy storage (TES). It's porosity and thermal conductivity allow for efficient heat transfer and heat retention, crucial for storing thermal energy during lunar day-night cycles. By using regolith as a TES medium, lunar habitats and infrastructures can effectively capture excess heat during the day and release it when needed during cold lunar nights.TES using regolith holds immense potential for addressing the energy and thermal management challenges inherent to lunar exploration and habitation. By harnessing the unique properties of regolith as a storage material, innovative TES systems can contribute to the sustainability, resilience, and advancement of lunar infrastructure, paving the way for long-term human presence on the Moon.
Liolaemus major Boulenger
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus major

description: Liolaemus major Boulenger
Liolaemus pictus var. major Boulenger 1885a: 152 (type locality: “ Chili ”).
Liolaemus capillitas Hulse 1979: 204 (synonymy fide Núñez 2004); McCoy & Censky 1982: 326; Vanzolini 1986: 13; Laurent 1992: 31; Cei 1993: 280; Etheridge 1995: 33; Etheridge & Espinoza 2000: 5; Lobo 2001: 139; Avila et al. 2003: 534; Chebez et al. 2005: 29; Sura 2005: 428; Díaz & Lobo 2006: 264; Díaz 2007: 114.
Liolaemus major Núñez 2004: 32.
Observations: After studying the collection of Liolaemidae types housed in the British Museum of Natural History of London, Núñez (2004) concluded that the type specimens originally named Liolaemus pictus var. major by Boulenger (1885a) are the species currently known as L. capillitas, from Argentina (Cei 1993). This type material is labeled as collected from “ Chili ” (Chile). Nevertheless, when Núñez (2004) reassessed the taxonomic status of these individuals, he did not propose a new type locality in accordance with the distribution of its synonymous L. capillitas (now L. major fide Núñez 2004). Consequently, although L. major (= L. capillitas) would be endemic to Argentina (see Cei 1993), its type locality is still recognized as “ Chili ”.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 26, DOI: 10.5281/zenodo.6789337
Drosophila cardinoides Dobzhansky & Pavan 1943
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila cardinoides

description: cardinoides Dobzhansky & Pavan
Drosophila cardinoides Dobzhansky & Pavan, 1943: 21.
Drosophila (Drosophila) cardinoides: Carson et al. 1983: 241 [records].
Distribution. Cryptogenic. Neotropical; Galápagos: Isabela, San Cristóbal, Santa Cruz.
Remarks. Adults of this species were most common in humid highlands (Carson et al. 1983).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 55, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Henosepilachna sumbana Bielawski
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Henosepilachna
Henosepilachna sumbana

description: Henosepilachna sumbana (Bielawski)
Epilachna vigintioctopunctata sumbana Bielawski, 1959: 147.
Epilachna cucurbitae Richards, 1983: 37 —synonymized by Jadwiszczak & Wegrzynowicz 2003: 173. Henosepilachna sumbana: Jadwiszczak & Wegrzynowicz 2003: 173.
Nomenclature of Epilachnini has been highly debated during recent decades, and H. sumbana has not been cited under this name in the context of local census. But, it is highly probable that the “ vigintioctopunctata ” recorded in the region (i.e. Epilachna with 28 dots), which attacks Cucurbitaceae, belongs to this species. It was originally described from Indonesia, but this taxon was redescribed from Australia (Epilachna cucurbitae Richards, 1983, synonymized with Epilachna sumbana Bielawski, 1959: Jadwiszczak & Wegrzynowicz, 2003, as quoted by Slipinski 2007). It is also recorded widely in Asia and the Pacific region (Australia, Indonesia, West Timor, Philippines, Papua New Guinea, Solomon Islands, Vanuatu, Fiji Islands, Samoa and Wallis & Futuna). This species was not recorded by Bielawski (1972) and therefore must have been introduced accidentally to New Caledonia after Bielawski’s study. This ladybug was frequent around Nouméa and Dumbéa counties by the end of the 1970s (Chazeau, pers. obs.), but today it is rarer. In New Caledonia, its host plants are cultivated or wild Cucurbitaceae, suggesting that this species belongs to the vigintioctopunctata species complex, whereas the two Australian species are specific to Solanaceae (Richards & Filewood 1990).
Material examined. NEW CALEDONIA: Dumbéa, 9.ii.1977 (J. Chazeau rec.) (ONNC).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 315, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Drosophila hydei Sturtevant 1921
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila hydei

description: hydei Sturtevant
Drosophila hydei Sturtevant, 1921: 101.
Drosophila (Drosophila) hydei: Carson et al. 1983: 241 [records]; Peck et al. 1998: 228 [introduced species]; Causton et al. 2006: 133 [introduced species].
Distribution. Introduced. Cosmopolitan; Galápagos: Isabela, Santa Cruz.
Remarks. Adults of this species were most common in humid highlands (Carson et al. 1983).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 55, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Subcellular basis of nicotine-induced receptor upregulation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking causes the death of nearly half a million Americans each year. Nicotine, the primary active component of tobacco exerts its addictive effects by binding to proteins called the neuronal nicotinic acetylcholine receptors (nAChRs). nAChRs possess a central pore for the passage of calcium and sodium ions into the cell from the external environment. Proteins called subunits are arranged around this central pore to form a receptor. nAChRs are activated upon binding to nicotine and allow calcium ions to enter the cell. In a chronic smoker, the persistent activation of nAChRs results in an increased number of receptor subunits that assemble in nerve cells of the brain to form functional receptors. This phenomenon, called upregulation has been identified as (i) the primary reason for nicotine addiction and (ii) the cause for relapses that can occur after quitting smoking. To study the mechanisms of upregulation by nicotine, I have created nAChR subunits tagged with fluorescent proteins so that they can be directly visualized in live cells using fluorescence illumination and microscopy. I will use specialized high-resolution microscopy methods to study changes in nAChR subunit assembly and movement of fluorescently tagged nAChRs within sub-regions of nicotine treated cells and at the surface of the cell. In addition, I will try to identify cellular unique processes and molecules that can control the assembly and movement of nAChRs in cells with and without exposure to nicotine. Success in these experiments will allow the identification of key processes that cause nAChR upregulation following exposure to nicotine. This can potentially lead to the development of a new generation of drugs that can specifically reduce the number of nAChRs in a smoker’s brain without side-effects thus minimizing the chances of relapse.
Additional file 1: of Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial
Creators: name: Tamura, Tomoyoshi
name: Hayashida, Kei
name: Sano, Motoaki
name: Onuki, Shuko
name: Suzuki, Masaru
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Completed Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) checklist of recommended items to address in a clinical trial protocol. (DOC 125 kb)
Pathological Angiogenesis and Nicotine:Intracellular Calcium
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is a major cause of heart disease, tumor and visual loss. Each of these is caused in part by abnormal vessel formation (pathological angiogenesis). We have discovered that tobacco smoke can cause abnormal vessel formation, because of the nicotine within it. Nicotine hijacks the body’s mechanism for growing new blood vessels (the growth of new blood vessels is a normal process required for wound healing). Nicotine does so by activating specific receptors on blood vessels. These receptors (nicotinic acetylcholine receptors, or nAChRs) are normally stimulated by the body’s own molecules, most particularly acetylcholine. Nicotine over-stimulates the nAChRs to cause abnormal vessel growth. Abnormal vessel growth plays a role in the growth of tumors and vessel plaque. Abnormal vessel growth in the back of the eye (age-related maculopathy or AMD) is the major cause of blindness in this country. The major preventable risk factor for tumor, plaque, and AMD is tobacco.

 We have shown that certain drugs, which block the nAChR, can reduce abnormal vessel growth in animal models of tumor, plaque, and AMD. Indeed, based upon our work, the FDA has now approved a study in people with AMD to determine if a drug that blocks the nAChR can prevent visual deterioration (by blocking abnormal retinal vessel formation).

 However, we still know very little about how the nAChR regulates the cells in blood vessels. This study is directed towards understanding how stimulation of the nAChR activates blood vessels to grow. Our work has already resulted in a possible new drug for a tobacco-related disease. The work that we now propose is intended to provide new and useful knowledge about how the nAChR controls the inner workings of the cells that make up the blood vessel. The study is driven by our intent to refine a new therapeutic strategy for tobacco-related disease.
Liolaemus maldonadae Navarro & Nunez 1991
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus maldonadae

description: Liolaemus maldonadae Navarro & Núñez
Liolaemus maldonadae Navarro & Núñez (in Núñez et al. 1991): 80 (type locality: Los Molles, Los Andes Range of Coquimbo Region, Chile); Núñez & Jaksic 1992: 74; Etheridge 1995: 33; Etheridge & Espinoza 2000: 7; Lobo 2001: 139; Sura 2005: 429; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) maldonadae Pincheira-Donoso & Núñez 2005: 329.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 27, DOI: 10.5281/zenodo.6789337
Additional file 1 of Systematic investigation of the material basis, effectiveness and safety of Thesium chinense Turcz. and its preparation Bairui Granules against lung inflammation
Creators: name: Peng, Guang-Cheng
name: Hao, Jin-Hua
name: Guan, Yue-Qin
name: Wang, Ying-Yue
name: Liu, Ming-Jie
name: Li, Guo-Hui
name: Xu, Zhen-Peng
name: Wen, Xue-Sen
name: Shen, Tao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Additional figures and tables.
Role of nicotine and nAChRs in L-dopa-induced dyskinesias.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Parkinson’s disease is characterized by a progressive neurodegeneration of nigrostriatal dopamine neurons, which affects ~1% of the populations over the age of 60 years. Current therapy using dopamine replacement with L-dopa greatly improves parkinsonian symptoms, including akinesia, rigity, tremor and postural imbalance. However, most patients develop side effects, such as dyskinesias or abnormal involuntary movements (AIMs) that can be as debilitating as the disease itself. Currently, the lack of treatment for dyskinesias limits the utility of L-dopa therapy for Parkinson’s disease. There are three strategies have been used to delay the onset of this motor complication. These include the use of dopamine receptor agonists, glutamate antagonists, and deep brain stimulation. However, these treatments either yield inconsistent improvement or lead to severe side effects. Since L-dopa is still the best treatment for Parkinson’s disease, therapies to prevent/reduce L-dopa-induced dyskinesias are being tested.

 Our recent studies show that nicotine, a component present in tobacco, reduces L-dopa-induced dyskinesias. Nicotine acts on multiple nicotinic receptors located at both central and peripheral sites, which results in the desired responses but also other effects. Interestingly, only select nAChR subtypes are expressed in the nigrostriatal pathway, the brain system relevant to Parkinson’s disease and L-dopa-induced dyskinesias. Thus, the goal of the present proposal is to identify the specific nicotinic receptor subtypes through which nicotine treatment reduces L-dopa-induced dyskinesias and the molecular mechanisms that are involved. To approach this, we will use nicotinic receptor subunit null mutant mice. These include â2, á4, á6 and á7 subunit null mutant mice, because nicotinic receptors containing these subunits are expressed in the nigrostriatal pathway linked to L-dopa-induced dyskinesias. These studies would provide information to identify the involvement of specific nicotinic receptor subtypes in nicotine-mediated antidyskinetic effect. In addition, we will also investigate the pre- and postsynaptic mechanisms whereby nicotine reduces L-dopa-induced dyskinesias. These include measures of dopamine levels and dopamine metabolism at presynaptic sites, as well as the changes in postsynaptic dopamine receptor-mediated signaling cascades such as protein kinase A (PKA) and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP32).

 Taken together, this study will advance our knowledge of the roles of nicotinic receptor subtypes and their downstream signaling in development of L-dopa-induced dyskinesias forParkinson’s disease. The outcomes of these experiments have important implications for the development of therapeutic strategies for L-dopa-induced dyskinesias.
Additional file 1 of Effect of erbium, chromium-doped: yttrium, scandium, gallium, and garnet laser-assisted periodontal therapy using radial firing tip during early healing period: a randomized controlled split-mouth clinical trial
Creators: name: Park, Jung Soo
name: Jung, Hannah
name: Ryu, Jae-Jun
name: Koo, Ki-Tae
name: Lee, Jaebum
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Developmental Biology

description: Supplementary material 1.
Drosophila immigrans Sturtevant 1921
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila immigrans

description: immigrans Sturtevant
Drosophila immigrans Sturtevant, 1921: 83. Curran 1932: 355 [records]; Curran 1934: 162 [records]; Wheeler 1961: 750 [records]; Linsley & Usinger 1966: 169 [checklist]; Delgado Zúñiga 1975: 38 [chromosomal analysis].
Drosophila (Drosophila) immigrans: Carson et al. 1983: 241 [records]; Peck et al. 1998: 228 [introduced species]; Causton et al. 2006: 133 [introduced species].
Distribution. Introduced. Cosmopolitan; Galápagos: Floreana, Santiago.
Remarks. This species breeds in decaying fruits and other plant material.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 55, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667