cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The cortical mechanisms underlying human spatial navigation: from afferent processing to motor efference
Creators: name: Kaski, Diego
Publisher: name: Imperial College London
Year: 2013

description: The research described in this thesis examined the cortical mechanisms underlying human spatial navigation, both from afferent and efferent perspectives, using healthy individuals and patients with focal cortical lesions. Specifically, the role of the posterior parietal cortex in the neural integration of vestibular signals for self-location perception was examined in a series of behavioural experiments (Chapter 2) assessing position, motion, and timing perception during angular rotations in the dark. Hippocampal cells have been associated with spatial navigation involving allocentric (map-based) co-ordinates. A combination of landmark-based orientation and vestibular path integration paradigm was used to evaluate the role of the right hippocampus in vestibular working memory related to allo-, and ego-centric navigation (Chapter 3). A new hypothesis relating to theta oscillation synchronisation for binding spatial (and non-spatial) conjunctions is proposed. Vestibular-guided self-motion relies upon visual calibration, for sighted individuals. Blind individuals, however, are said to possess a "supersense" as a result of cross-modal plasticity. Blind versus sighted performance was compared using a vestibular-guided auditory localisation task in footballers (Chapter 4), and both in turn compared to sighted non-footballers. This enables a fair assessment of the relative contribution of practice versus innate "supersense" for spatial performance. Gait is a necessary component of spatial navigation in humans, and the ability to adapt locomotor behaviour to a change in the environment is essential for everyday activity. Using the "broken escalator" paradigm, the role of the primary motor cortex and premotor regions for gait adaptation was assessed in healthy participants, using non-invasive transcranial direct current stimulation (tDCS; Chapter 5). This technique was then applied in combination with physical therapy to patients with Parkinson‟s disease (Chapter 6) and patients with small vessel disease (Chapter 7) – a common cause of gait dysfunction in the elderly –to improve gait and balance function. The complementary study in a single patient with Parkinson‟s disease combining tDCS with tango dancing examined whether non-invasive brain stimulation could preferentially augment the effects of this form of physical therapy in a clinically-relevant manner (Appendix).
Small-signal Analysis of Active Loads and Large-signal Analysis of Faults in Inverter Interfaced Microgrid Applications
Creators: name: Bottrell, Nathaniel
Publisher: name: Imperial College London
Year: 2013

description: Rectifiers and voltage regulators that have characteristics of constant power loads may form a significant percentage of a microgrid's total loads. The real part of the input impedance of a constant power load is negative and it may have control loop dynamics in a similar frequency range to the inverters that are supplying the microgrid. This thesis examines the interactions between an active constant power load and a microgrid for the impact on stability. Participation analysis of the eigenvalues that result from the model of the combined microgrid and active load identified that the low-frequency modes are associated with the voltage controller of the active rectifier and the droop-controllers of the inverters. The analysis also revealed that when the active load dc-voltage controller is designed with large gains, the voltage controller of the inverter becomes unstable but the low frequency modes associated with the droop controller of the inverter remain stable. The transient stability of a microgrid may require that the inverter-interfaced generation remain connected during a fault and return to normal power export once a fault is cleared. For an inverter to supply fault current, the controller of the inverter must current-limit the output and the fault strategy chosen must ensure that the current and voltage limiter do not latch-up and that the controller integrators do not wind-up. This thesis analyses different limiting and reset strategies and concluded that that it is not possible to successfully reset a limiter when using a reset signal from a closed-loop controller within the inverter. In a system where there are cascaded limiters, successful operation is obtained when the inner limit is a saturation limiter and the output limiter is a set-reset limiter. It was found that the transient stability of an inverter interfaced microgrid using a droop control algorithm is dependent on the current limiter and inductance of the network.
Additional file 1 of Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database
Creators: name: Wei, Wei
name: Li, Siwei
name: Cheng, Linyou
name: Hao, Erwei
name: Hou, Xiaotao
name: Zhou, Hua
name: Deng, Jiagang
name: Yao, Xinsheng
Publisher: name: figshare
Year: 2021
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Science Policy

description: Additional file 1: Table S1. The chemical compounds of YGMM collected from literatures. Table S2. The screened candidate compounds in YGMM. Figure S1. The chemical structures of identified constituents in YGMM. Figure S2. The possible fragment pathway of 3-O-feruloylquinic acid. Figure S3. The possible fragment pathway of quercetin. Figure S4. The possible fragment pathway of 5,6,7,8,3′,4′-hexamethoxyflavanone. Figure S5. The possible fragment pathway of Z-Ligustilide. Figure S6. The possible fragment pathway of paeoniflorin. Figure S7. The possible fragment pathway of polygoside A. Figure S8. The possible fragment pathway of emodin-3-methyl ether.
Dissipation and memory capacity in the quantum brain model
Creators: name: Vitiello, Giuseppe
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum model of the brain proposed by Ricciardi and Umezawa is extended to dissipative dynamics in order to study the problem of memory capacity. It is shown that infinitely many vacua are accessible to memory printing in a way that in sequential information recording the storage of a new information does not destroy the previously stored ones, thus allowing a huge memory capacity. The mechanism of information printing is shown to induce breakdown of time-reversal symmetry. Thermal properties of the memory states as well as their relation with squeezed coherent states are finally discussed.
description: 24 pages, Tex file
Additional file 1 of A network meta-analysis evaluating the efficacy and safety of adjuvant therapy after nephrectomy in renal cell carcinoma
Creators: name: Guo, Lingyu
name: An, Tian
name: Huang, Zhixin
name: Chong, Tie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
The role of the killer immunoglobulin-like receptor in haematological malignancies and stem cell transplantation
Creators: name: Gabriel, Ian
Publisher: name: Imperial College London
Year: 2012

description: Natural killer cells (NK) cells are marrow-derived cytotoxic lymphocytes, representing 5-18% of human blood mononuclear cells. NK cells are an important component of the innate immune system in humans playing important roles in both the elimination and control of tumour metastases and leukaemia. NK activity against target cells is determined, by the net balance of the transmitted intracellular signals from both activating (pro-cytotoxic) and inhibitory (anti-cytotoxicity) cell surface receptors. One major class of such receptor is the Killer immunoglobulin-like receptors (KIRs), which were investigated in detail in this study. Using KIR genotype and HLA typing, I found that the KIR2DS1 positive genotype was an independent predictor for failure to achieve complete cytogenetic response (CCyR) and for inferior progression-free survival (PFS) in patients with chronic myeloid leukaemia in first chronic phase disease (CML-CP) treated with tyrosine kinase inhibitors. This was validated in a further 174 CML-CP patients and demonstrated therefore that KIR-HLA immunogenetics is a novel prognostic tool for patients with CML in CP. Following this finding, I hypothesised that as KIR-HLA genotype can predict for outcome in haematological malignancy, then their influence might be greatest at a time of relative NK cell predominance, such as in the immediate post transplant setting. I therefore went on to investigate and demonstrate in the malignancy multiple myeloma (MM), that KIR3DS1 positivity may identify patients at greater risk of progression after an autologous stem cell transplant, and further that there was a significant association of the KIR2DS2/DL2 genotype with acute graft-versus host disease (aGVHD) following allogeneic stem cell transplant. I finally demonstrate that the association of KIR2DS2/DL2 with GvHD is likely due to the demonstration that KIR2DS2/DL2 expressing cells have a significantly greater capacity for the production of IFN-gamma and TNF-alpha, which are directly associated with aGvHD with a relative reduction in IL-2 production which is important for regulatory T-cell development. In conclusion my data show that KIR genotype predicts both the response to targeted therapy in CML, that the role of KIR is also important in disease control during haematopoeitic reconstitution following transplant and that certain KIR molecules associate with increased incidence and severity of aGvHD and this may be mediated by the increased propensity to produce TNF-α, IFN-γ, MIP1-alpha, and MIP1- beta and a reduction in IL-2.
The Effect of Rankings on Judgment and Behaviour
Creators: name: Teekathananont, Gunyawee
Publisher: name: Imperial College London
Year: 2013

description: Rankings reveal important information about relative performance in competitive settings. Despite their widespread use, relatively little about their psychological impact on individuals’ decisions and behaviours is known. Such a limited understanding of both the beneficial and detrimental effects of rankings may lead to undesirable and unintended consequences. In this thesis I try to fill that gap by investigating how rankings can affect our judgment in four main areas. First, I explore the effect of rankings on the perceived potential of performance improvement and how this influences individuals’ aspiration levels. I also identify a factor that moderates this effect. Second, I examine the role of rankings in a competition between two commensurate rivals by exploring the relationship between rankings and predicted winning probabilities, and how this judgment is shaped by competitors’ inferences about relative capabilities. Third, I explore the role of rankings on pay requests, and show how this effect is mediated by personal entitlement and moderated by the pay level of similarly ranked others. Finally, I show how rankings influence the decision to cooperate with similarly-ranked rivals under gain and loss situations. The results suggest that the judgments and decisions of high-ranking individuals vary markedly from those of low-ranking individuals. Specifically, high-ranking individuals – in contrast to lower-ranked individuals – tend to set lower aspiration levels, predict lower winning probabilities when competing with commensurate rivals, demand higher pay, and are more sensitive about their cooperation decisions when the situational contexts change. I end with a general discussion of the findings, their theoretical and managerial implications, and suggestions for future research.
Low Velocity Impact on Pre-Loaded Composite Structures
Creators: name: Ehrich, Fabian
Publisher: name: Imperial College London
Year: 2013

description: Low velocity impact is a serious hazard for laminated composite structures. It can result in considerable loss of mechanical performance and must be taken into account during the design process. Extensive knowledge of the composite damage processes and advanced numerical simulation tools can help find optimal designs and reducing development costs. In addition to normal service loads such as bending moments, shear forces, torques, pressure loads, etc. airframe structures also have to withstand impact loads resulting from hailstones, runway debris or tool drops during maintenance work. These impacts are likely to happen while the airframe is stressed under normal service loads. The superposition of service loads and impact loads is likely to alter the impact response of a structure compared to an unloaded structure. In this work, the influence of in-plane compressive loads on the low velocity impact response of carbon fibre epoxy composites is studied. Low velocity impact experiments on T800s/M21 UD carbon fibre epoxy laminates, under various compressive pre-strains, have been carried out with impact energies of up to 45J. The compressive pre-load applied to the structure was observed to significantly increase the impact damage and reduce the post-impact strength. To predict the damage resulting from impacts with and without pre-loads, a 2D damage model has been developed and implemented into the commercial finite element code ABAQUS/Explicit. The model is based on a combination of continuous damage mechanics and fracture mechanics with interactions between damage modes considered for both, damage initiation and damage propagation. Thereby damage degradation is following non-linear propagation laws. The model's material degradation is governed by the material's fracture toughnesses which are important material input parameters for the damage model. A detailed series of laboratory tests have been conducted to develop test set-ups for the measurement of translaminar fracture toughness values, which are used as input units for the damage model.
Protein-protein interaction of HSV-1 tegument proteins
Creators: name: Stylianou, Julianna
Publisher: name: Imperial College London
Year: 2013

description: Herpes simplex virus type 1 virions contain a proteinaceous layer between the nucleocapsid and the virus envelope termed the tegument. The mechanism underlying tegumentation remains largely undefined for all herpesviruses, as does the role of many tegument proteins in virus replication. The networks of protein interactions involved in virus assembly have been largely explored and although large-scale studies have been carried out using yeast two hybrid analyses of herpesvirus protein interactions, few of the identified networks have been validated in infected cells. Here, the molecular interactions that occur between the major tegument proteins VP22, VP16 and VP13/14 and a range of glycoproteins and tegument proteins were defined in detail. Two alternative studies were performed from infected cells, however one based on the purification of GFP-tagged proteins and their protein partners proved more successful. These studies validated previous findings and also identified VP13/14, UL21, UL16 and vhs as novel binding partners of VP22, and VP22, UL21, UL16 and vhs as novel binding partners of VP13/14. Thus, these results have led to the identification of two discrete tegument protein complexes in the infected cell: VP22-VP16-VP13/14-vhs and VP22-VP13/14-UL21-UL16. To investigate the nature of the VP22-VP16-VP13/14-vhs complex in more detail, a number of techniques were used and showed that VP22 and VP13/14 both bind directly to the C-terminus of VP16, but were unable to interact with each other. As anticipated from other studies on transfected cell extracts, vhs was shown to be incorporated into this complex by virtue of its direct binding to VP16 during infection, and did not have the capacity to interact directly with VP22. This work has established a defined network of protein-protein interactions encompassing over one third of tegument proteins, and will improve our understanding of the wider protein interaction networks that lead to the assembly of the herpesvirus tegument.
Anderson localization at the hybridisation gap in a plasmonic system
Creators: name: Balasubrahmaniyam, M.
name: Nahata, Ajay
name: Mujumdar, Sushil
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Disorder-induced Anderson localization in quasiparticle transport is a challenging problem to address, even more so in the presence of dissipation as the symptoms of disorder-induced localization are very closely simulated by the absorption in a system. Following up on recent experimental studies, we numerically study the occurrence of Anderson localization in plasmonic systems at terahertz frequencies. The low losses in the material at these frequencies allow us to separately quantify the localization length and the loss length in the system. We measure a non-monotonic variation of loss length as a function of disorder, and attribute it to the participation ratio of the localized modes and resulting light occupancy in the metal. Next, we identify a unique behavior of the gap state frequencies and the density of states under disorder. We observe that the maximally displaced gap state frequencies have a propensity to remain pinned to the frequency of the gap center. Even under strong disorder, the gap does not close, and density of states profile continues to remain peaked in the gap, unlike in conventionally studied disordered systems. The origins of this behavior are traced to the nature of the quasiparticle dispersion. In our case, the quasiparticles are identified to be hybrid plasmons generated due to the hybridization of surface plasmon polaritons at a metal-dielectric interface and cavity resonances at sub-wavelength apertures thereon. This situation is akin to the Kondo systems, where dispersive conduction electrons hybridise with a localized impurity state opening a hybridization gap. Our results provide new insights on the elusive problem of the interplay of loss and localization, and underlines interesting physics at the hybridisation gap in hybrid plasmonic systems.
description: 10 pages, 9 figures
Metapopulation Modelling and Spatial Analysis for HEG Technology in the Control of Malaria
Creators: name: Dickens, Borame
Publisher: name: Imperial College London
Year: 2014

description: The success of any vector control strategy can be enhanced by onsite analysis and investigation. Combatting malaria, a global disease carried by the vector Anopheles gambiae, has led to the development of novel genetic technologies such as the use of HEG; homing endonuclease genes. This thesis explored the age and stage elements of the vector, building upon current biological understanding and using fitting algorithms with metapopulation matrices to create cohort orientated survival and transition. The environmental forces were analysed alongside this with emphasis on sub-model creation and tool design, employing an array of methods from RBF to satellite classification to couple the local environment and vector. When added, the four potential genetic strategies all demonstrated the ability to suppress a wild type population and even eradicate it, although reinvasion and hotspot population phenomena were reoccurring observations. The movement of the vector was an important factor in control efficiency, which was investigated as a series of different assumptions using wind driven movement and host attraction. Lastly, practical factors such as monitoring and resource distribution within a control project were assessed, which required routing solutions and landscape trapping assessments. This was explored within a framework of Mark-Release-Recapture experiment design that could provide critical information for efficient HEG release strategies.
Studies towards the synthesis of the antibiotic lactonamycin
Creators: name: Walsh, Lee
Publisher: name: Imperial College London
Year: 2014

description: Transition metal-free, thermal cyclisation methodology has been demonstrated previously in the Parsons group, with the vision of applying the process to a novel synthesis of the antibiotic Lactonamycin. i. The synthesis of the aglycone of i has been proposed from the pentacyclic intermediate ii, which itself is the hypothesised product of the Parsons-BoardWaters cyclisation of the ene-diyne iii. (Scheme A - see thesis abstract) The phthalide v was synthesised from 2,5-dimethoxybenzaldehyde in 3 steps in moderate yield and was seen as a common starting material for the subsequent routes devised to provide the key aldehyde vi. A further mode of complexity was proposed by attempting to perform the Claisen rearrangement of the alkene vii in cascade with the aforementioned cyclisation to give the amide ii. (Scheme B - see thesis abstract)
Reminiscences of Abraham Kazan, 1968
Publisher: name: Columbia University
Year: 2021
Subjects: Housing
Housing, Cooperative
Labor unions--Officials and employees

description: Early life; immigration to United States; International Ladies' Garment Workers' Union; Union Welfare Fund; International Ladies' Garment Workers' Union Cooperative Ventures; union housing; problems in cooperative housing; Twin Lake Cooperative Farm; United Housing Foundation; self help in cooperatives. Recollections of Sidney Hillman, Robert Moses, Jacob Potofsky
Tough natural-fibre composites
Creators: name: Techapaitoon, Mana
Publisher: name: Imperial College London
Year: 2015

description: Natural fibre composites (NFCs) possess relatively good specific strength and stiffness properties. However, natural fibres (NFs) often show relatively poor interfacial adhesion with respect to polymeric matrices, may contain relatively high levels of moisture and have variable mechanical properties due to the route by which they have been harvested and manufactured. These aspects may result in inconsistent mechanical properties of such composites, especially evident in a poor interlaminar fracture toughness. Thus, the present work investigates the mode I interlaminar fracture toughness, of NFCs based upon an anhydride-cured diglycidyl ether of bisphenol-A (DGEBA) epoxy matrix. Further, this matrix was used as a ‘control’ or modified with silica nanoparticles and/or rubbery microparticles. Two types of natural fibres were employed: unidirectional flax fibre (FF) and plain-woven regenerated cellulose fibre (CeF). Two very different routes were explored for the production of the NFCs based upon these materials. One route was via a resin infusion under flexible tooling (RIFT) process and a second route employed a resin transfer moulding (RTM) process. A very low value of the interlaminar fracture energy of about 20 J/m2 was measured for the flax fibre-reinforced plastics (FFRPs), using the ‘control epoxy matrix, produced by the RIFT manufacturing process which was initially employed. However, such composite manufactured via the RTM process possessed fracture energy of about 963 J/m2. Further, this value was found to increase to 1264 J/m2 when the epoxy matrix was modified using a combination of silica nanoparticles and rubbery microparticles. Hence, optimization studies using the RIFT manufacturing process were undertaken which led to a simple modification of this manufacturing route whereby the natural fibres were first oven-dried. This resulted in the final RIFT process giving values of the fracture toughness of the same order as those obtained from the RTM process. Also of note was the observation that the FFRPs manufactured via the RTM or the final RIFT process had similar values of toughness as those measured for glass fibre-reinforced plastics (GFRPs) made using the equivalent type of epoxy matrix. Similar observations were recorded in the case of the cellulose fibre-reinforced plastics (CeFFRPs). The present study has also considered the underlying mechanisms for the above observations and used analytical models to predict the toughening mechanisms and a good agreement between the predictions and the experimental data for the NFCs was obtained.
Reminiscences of Abram Kardiner 1963
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Psychoanalysts
subject: Psychoanalysis
subject: Psychiatry
subject: Anthropology
subject: FOS: Sociology

description: Early childhood and education in New York City; Cornell Medical College; analysis by Sigmund Freud; Vienna in the 1920s, association with leading figures in the psychoanalytic movement; work with Drs. W.H. Frink, A. A. Brill, Otto Rank, Franz Alexander; New York psychoanalytic movement, 1920s and 1930s; activities and associations as lecturer in anthropology, Columbia University; chairman of Columbia Psychoanalytic Clinic's research seminar on comparative analysis of cultures, 1939-51; director, 1955-57; development as practicing psychoanalyst, interest in anthropology; research in the relation of psychiatry and the social sciences; discussion of his major books.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 180 (11 H 755), 83 folios, f. 0021
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 180 (11 H 755), 83 folios, f. 0021, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 180 (11 H 755), 83 folios, f. 0021, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
A mathematical model of cell cycle heterogeneity for personalizing leukemia chemotherapy
Creators: name: Fuentes Gari, Maria
Publisher: name: Imperial College London
Year: 2015

description: Acute myeloid leukemia is a type of blood cancer characterized by an excessive build-up of immature blood cells in the bone marrow and blood streams. As a result, healthy stem cells become space- and resource-limited, and do not produce enough functional cells for the body to operate normally. Treatment is required immediately, consisting of intensive chemotherapy. Chemotherapy dosage and schedule are derived from established protocols which do not account for patient-specific and disease-specific heterogeneity. Over- or under- dosage are thus common; a more rational and personalized approach to chemotherapy treatments is required. Specifically, incorporating the effect of chemotherapy in a cell cycle phase-specific manner would be highly beneficial. In this work, we developed a population balance model (PBM) of the cell cycle based on the underlying biology that captures the progress of cells within and between phases. It was validated with three leukemia cell lines separately for the duration of one cell cycle, and in variable mixtures where forward and backward kinetics as well as clonal identification were successfully performed. The model was compared against two other cell cycle models: an existing ODE model and a newly developed DDE model featuring phase durations as delays. The PBM outperformed the other two in recapitulating biological features, and displayed a higher sensitivity to treatment when coupled to an existing pharmacokinetic/pharmacodynamic model of chemotherapy treatment. The PBM was further used in the prediction of clonal evolution during chemotherapy, highlighting the important heterogeneity in treatment response between clones but also the competitive features among them that could be critical in the success of the treatment. Finally, the first steps towards implementing this technology at clinical level were taken by defining converted, measurable data sets. A prototype application, "ChemoApp", was developed at the user interface level for the introduction of this research into clinical practice.
Supplementary Material for: The Persevering Cytotaxonomy: Discovery of a Unique XX/XY Sex Chromosome System in Catfishes Suggests the Existence of a New, Endemic and Rare Species
Creators: name: Rocha-Reis, D.A.
name: De Oliveira Brandão, K.
name: De Almeida-Toledo, L.F.
name: Pazza, R.
name: Kavalco, K.F.
Publisher: name: Karger Publishers
Year: 2018
Subjects: Medicine

description: The genus Hypostomus has a broad geographic distribution in Brazilian rivers and comprises armored catfishes with a very complicated taxonomy due to the absence of morphological autapomorphies. The existence of nearly 10 allopatric populations with different karyotypes suggests that Hypostomusancistroides represents a species complex in the Upper Paraná River basin. In this paper, an unusual karyotype of an isolated H. aff. ancistroides population was investigated. All specimens of this sample have 2n = 66 chromosomes except for 1 male with 2n = 67, most likely due to a supernumerary chromosome. In this population, the sexes are dimorphic, the males are heterogametic, and an XX/XY sex chromosome system is present. Phylogenetic analysis using mitochondrial and nuclear DNAs indicated that this population forms a monophyletic group separate from the other populations of H.ancistroides and may represent an incipient species.
Structural and functional studies of the Apical Sodium Dependent Bile Acid Transporter
Creators: name: Sekiguchi, Yusuke
Publisher: name: Imperial College London
Year: 2014

description: The apical sodium dependent transporter (ASBT) is responsible for the uptake of bile acids from the apical membrane of the ileum cell. Loss of function mutations of ASBT relate to several diseases, such as Crohn’s disease and Primary Bile Acid Malabsorption (PBAM). It is also a target for drugs aimed at lowering cholesterol. The X-ray crystal structure of a bacterial homologue of ASBT, ASBTNM, was previously solved at 2.2Å. In order to understand mechanism of ASBT transport in more detail, further structural and functional information are required. In this thesis, a proteoliposome transport assay was performed for various mutations of residues in the sodium and substrate binding sites. ASBTNM has two sodium binding sites and the residues involved in the sites are functionally important. Both E260A and Q77A showed significantly lower transport activities compared to wild type at 40% and 60% respectively. E260 binds to one sodium ion and Q77 the other. The X-ray crystal structures of these two ASBTNM mutants were solved at 2.9 Å and 3.2 Å respectively. These mutant structures revealed that no large scale conformational changes from the wild type were observed though the mutations clearly affected sodium ion binding. These structural and functional data suggest that both two sodium ions are important for the transport activity of ASBTNM. However even without sodium ions in the binding sites, the protein can take the same conformation as the wild type structure. The data presented in this thesis, together with a comparison with the results from another bile acid transporter that was recently solved, and a homology model of human ASBT, provide insight into the transport mechanism of ASBT.
Additional file 1 of Network-level functional topological changes after mindfulness-based cognitive therapy in mood dysregulated adolescents at familial risk for bipolar disorder: a pilot study
Creators: name: Qin, Kun
name: Lei, Du
name: Yang, Jing
name: Li, Wenbin
name: Tallman, Maxwell J.
name: Duran, Luis Rodrigo Patino
name: Blom, Thomas J.
name: Bruns, Kaitlyn M.
name: Cotton, Sian
name: Sweeney, John A.
name: Gong, Qiyong
name: DelBello, Melissa P.
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Neuroscience
Biological Sciences not elsewhere classified
Mental Health

description: Additional file 1.
The Southern Sky Redshift Survey
Creators: name: da Costa, L. Nicolaci
name: Willmer, C. N. A.
name: Pellegrini, P. S.
name: Chaves, O. L.
name: Rite, C.
name: Maia, M. A. G.
name: Geller, M. J.
name: Latham, D. W.
name: Kurtz, M. J.
name: Huchra, J. P.
name: Ramella, M.
name: Fairall, A. P.
name: Smith, C.
name: Lipari, S.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report redshifts, magnitudes and morphological classifications for 5369 galaxies with $m_B \leq 15.5$ and 57 galaxies fainter than this limit, in two regions covering a total of 1.70 steradians in the southern celestial hemisphere. The galaxy catalog is drawn primarily from the list of non-stellar objects identified in the Guide Star Catalog (Lasker et al. 1990, AJ 99, 2019; hereafter GSC). The galaxies have positions accurate to about 1 arc sec and magnitudes with an rms scatter of about 0.3 mag. We compute magnitudes ($m_{SSRS2}$) from the relation between instrumental GSC magnitudes and the photometry by Lauberts & Valentijn (1989). From a comparison with CCD photometry, we find that our system is homogeneous across the sky and corresponds to magnitudes measured at the isophotal level $\sim$ 26 mag arcsec$^{-2}$. The precision of the radial velocities is of \sim 40 km/s and the redshift survey is more than 99% complete to the $m_{SSRS2}$ = 15.5 magnitude limit. This sample is in the direction opposite to the CfA2; in combination the two surveys provide an important database for studies of the properties of galaxies and their large-scale distribution in the nearby Universe.
description: 20 pages, uses AASTeX 4.0 macros. Includes 3 tables and 4 Postscripts figures. Scheduled for publication in the AJ 1998 July issue
Design for Pedagogy Patterns for E-learning Thesis
Creators: name: Chatteur, Fiona
Publisher: name: Torrens University Australia
Year: 2018
Subjects: subject: 80103 Computer Graphics
subject: FOS: Computer and information sciences
subject: 80302 Computer System Architecture
subject: 80603 Conceptual Modelling
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology

description: This research addresses the need to make explicit the relation between pedagogy and the user interface, information architecture and content layout of e-learning courseware through design patterns. To do so, this research conceptualises a new type of design pattern called a ‘design for pedagogy pattern’, which explicitly shows the relationships between pedagogic strategies associated with the design elements featuring in e-learning courseware and those associated with the general and abstract ways of thinking about education including the social and the educational context of the learning, the preferred teaching practices of the instructors, and the tactics for engaging students. By creating representative design for pedagogy patterns for e-learning, the aim of the research is to understand how design for pedagogy patterns modify the design process for e-learning courseware.
Additional file 1 of Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2
Creators: name: Kahm, Yeon-Jee
name: Kim, In-Gyu
name: Kim, Rae-Kwon
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
HST followup observations of two bright z ~ 8 candidate galaxies from the BoRG pure-parallel survey
Creators: name: Livermore, R. C.
name: Trenti, M.
name: Bradley, L. D.
name: Bernard, S. R.
name: Holwerda, B. W.
name: Mason, C. A.
name: Treu, T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present followup imaging of two bright (L > L*) galaxy candidates at z > 8 from the Brightest of Reionizing Galaxies (BoRG) survey with the F098M filter on HST/WFC3. The F098M filter provides an additional constraint on the flux blueward of the spectral break, and the observations are designed to discriminate between low- and high-z photometric redshift solutions for these galaxies. Our results confirm one galaxy, BoRG 0116+1425 747, as a highly probable z ~ 8 source, but reveal that BoRG 0116+1425 630 - previously the brightest known z > 8 candidate (mAB = 24.5) - is likely to be a z ~ 2 interloper. As this source was substantially brighter than any other z > 8 candidate, removing it from the sample has a significant impact on the derived UV luminosity function in this epoch. We show that while previous BoRG results favored a shallow power-law decline in the bright end of the luminosity function prior to reionization, there is now no evidence for departure from a Schechter function form and therefore no evidence for a difference in galaxy formation processes before and after reionization.
description: Accepted by ApJL, 7 pages, 4 figures
Reminiscences of Adelaide Oppenheim, 1976
Publisher: name: Columbia University
Year: 2021
Subjects: Women engineers
Engineers
Nuclear energy
Women executives

description: Education, Cornell 1930-34; State University of New York 1934-35; General Electric engineering lab, 1941, Heat Transfer Laboratory supervisor; Knolls Atomic Power Lab; courses on women in program management and Program Evaluation Review Technique (PERT) at the Graduate School of Continuing Education at Union College, Schenectady, NY, 1974
Quantum Electrodynamics at Large Distances III: Verification of Pole Factorization and the Correspondence Principle
Creators: name: Kawai, Takahiro
name: Stapp, Henry P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In two companion papers it was shown how to separate out from a scattering function in quantum electrodynamics a distinguished part that meets the correspondence-principle and pole-factorization requirements. The integrals that define the terms of the remainder are here shown to have singularities on the pertinent Landau singularity surface that are weaker than those of the distinguished part. These remainder terms therefore vanish, relative to the distinguished term, in the appropriate macroscopic limits. This shows, in each order of the perturbative expansion, that quantum electrodynamics does indeed satisfy the pole-factorization and correspondence-principle requirements in the case treated here. It also demonstrates the efficacy of the computational techniques developed here to calculate the consequences of the principles of quantum electrodynamics in the macroscopic and mesoscopic regimes.
description: latex, 39 pages, 2 Figures included as uuencoded, tarred, gzipped, encapsulated postscript files, uses math_macros.tex
The progeny of a Cosmic Titan: a massive multi-component proto-supercluster in formation at z=2.45 in VUDS
Creators: name: Cucciati, O.
name: Lemaux, B. C.
name: Zamorani, G.
name: Fevre, O. Le
name: Tasca, L. A. M.
name: Hathi, N. P.
name: Lee, K-G.
name: Bardelli, S.
name: Cassata, P.
name: Garilli, B.
name: Brun, V. Le
name: Maccagni, D.
name: Pentericci, L.
name: Thomas, R.
name: Vanzella, E.
name: Zucca, E.
name: Lubin, L. M.
name: Amorin, R.
name: Cassara', L. P.
name: Cimatti, A.
name: Talia, M.
name: Vergani, D.
name: Koekemoer, A.
name: Pforr, J.
name: Salvato, M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: [Abridged] We unveil the complex shape of a proto-supercluster at z~2.45 in the COSMOS field using the spectroscopic redshifts of the VIMOS Ultra-Deep Survey (VUDS), complemented by the zCOSMOS-Deep sample and high-quality photometric redshifts. The method relies on a 2D Voronoi tessellation in overlapping redshift slices that is converted into a 3D density field. The galaxy distribution is constructed using a statistical treatment of spectroscopic and photometric redshifts. We identify a proto-supercluster, dubbed "Hyperion" for its immense size and mass, which extends over a volume of ~60x60x150 comoving Mpc^3 and has an estimated total mass of ~4.8x 10^15 M_sun. This immensely complex structure contains at least 7 density peaks within 2.4 < z < 2.5, connected by filaments. Based on the peaks average matter density, we estimate their total mass, M_tot, and find a range of masses from ~0.1x10^14 M_sun to ~2.7x10^14 M_sun. By using spectroscopic members of each peak, we obtain the velocity dispersion of the galaxies in the peaks, and then their virial mass M_vir (under the strong assumption that they are virialised). The agreement between M_vir and M_tot is surprisingly good, considering that almost all the peaks are probably not yet virialised. According to the spherical collapse model, the peaks have already started or are about to start collapsing, and they are all predicted to be virialised by redshift z~0.8-1.6. We finally perform a careful comparison with the literature, given that smaller components of this proto-supercluster had previously been identified using heterogeneous galaxy samples. With VUDS, we obtain a panoramic view of this large structure, that encompasses, connects, and considerably expands in a homogeneous way on all previous detections of the various sub-components. This provides us the unique possibility to study a rich supercluster in formation.
description: 22 pages, 13 figures, accepted to be published in A&A, very minor corrections after language editing
Snapshot Distances to Type Ia Supernovae -- All in ``One'' Night's Work
Creators: name: Riess, Adam G.
name: Nugent, Peter
name: Filippenko, Alexei V.
name: Kirshner, Robert P.
name: Perlmutter, Saul
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present an empirical method which measures the distance to a Type Ia supernova (SN Ia) with a precision of ~ 10% from a single night's data. This method measures the supernova's age and luminosity/light-curve parameter from a spectrum, and the extinction and distance from an apparent magnitude and color. We are able to verify the precision of this method from error propagation calculations, Monte Carlo simulations of well-sampled SNe Ia, and the Hubble diagram of scarcely observed supernovae. With the reduction in telescope time needed, this method is three to four times more efficient for measuring cosmological parameters than conventional light-curve based distance estimates.
description: 32 pages, 5 figures, Accepted Astrophysical Journal
The Energy-Dependent Black-Disk Fraction in Proton-Proton Scattering
Creators: name: Schildknecht, Dieter
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent work by Block et al on the energy-invariant edge in proton-proton scattering is interpreted by quantitatively introducing a energy-dependent black-disk fraction of the proton-proton interaction.
description: 7 pages, expanded version, including impact-parameter representation and other details
Additional file 1 of Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer
Creators: name: Kang, Deyong
name: Wang, Chuan
name: Han, Zhonghua
name: Zheng, Liqin
name: Guo, Wenhui
name: Fu, Fangmeng
name: Qiu, Lida
name: Han, Xiahui
name: He, Jiajia
name: Li, Lianhuang
name: Chen, Jianxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Additional file 1 of SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures
Creators: name: Zuo, Zhaorui
name: Wang, Penglei
name: Chen, Xiaowei
name: Tian, Li
name: Ge, Hui
name: Qian, Dahong
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1. Drug and genes information for efficacy prediction.
Consistent use of paradoxes in deriving constraints on the dynamics of physical systems and of no-go-theorems
Creators: name: Svozil, Karl
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The classical methods used by recursion theory and formal logic to block paradoxes do not work in quantum information theory. Since quantum information can exist as a coherent superposition of the classical ``yes'' and ``no'' states, certain tasks which are not conceivable in the classical setting can be performed in the quantum setting. Classical logical inconsistencies do not arise, since there exist fixed point states of the diagonalization operator. In particular, closed timelike curves need not be eliminated in the quantum setting, since they would not lead to any paradoxical outcome controllability. Quantum information theory can also be subjected to the treatment of inconsistent information in databases and expert systems. It is suggested that any two pieces of contradicting information are stored and processed as coherent superposition. In order to be tractable, this strategy requires quantum computation.
description: 10 pages, latex, no figures
From metallic glasses to nanocrystals: Molecular dynamics simulations on the crossover from glass-like to grain-boundary-mediated deformation behaviour
Creators: name: Brink, Tobias
name: Albe, Karsten
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Nanocrystalline metals contain a large fraction of high-energy grain boundaries, which may be considered as glassy phases. Consequently, with decreasing grain size, a crossover in the deformation behaviour of nanocrystals to that of metallic glasses has been proposed. Here, we study this crossover using molecular dynamics simulations on bulk glasses, glass-crystal nanocomposites, and nanocrystals of Cu64Zr36 with varying crystalline volume fractions induced by long-time thermal annealing. We find that the grain boundary phase behaves like a metallic glass under constraint from the abutting crystallites. The transition from glass-like to grain-boundary-mediated plasticity can be classified into three regimes: (1) For low crystalline volume fractions, the system resembles a glass-crystal composite and plastic flow is localised in the amorphous phase; (2) with increasing crystalline volume fraction, clusters of crystallites become jammed and the mechanical response depends critically on the relaxation state of the glassy grain boundaries; (3) at grain sizes $\geq$ 10 nm, the system is jammed completely, prohibiting pure grain-boundary plasticity and instead leading to co-deformation. We observe an inverse Hall-Petch effect only in the second regime when the grain boundary is not deeply relaxed. Experimental results with different grain boundary states are therefore not directly comparable in this regime.
description: 19 pages, 17 figures