cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Toward Grid-Based Models for Molecular Association
Creators: name: Zupan, Hana
name: Keller, Bettina G.
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Energy
subject: Markov modeling
subject: Mathematical methods
subject: Molecular modeling
subject: Molecules
classificationCode: 540
subject: Chemie und zugeordnete Wissenschaften

description: This paper presents a grid-based approach to model molecular association processes as an alternative to sampling-based Markov models. Our method discretizes the six-dimensional space of relative translation and orientation into grid cells. By discretizing the Fokker–Planck operator governing the system dynamics via the square-root approximation, we derive analytical expressions for the transition rate constants between grid cells. These expressions depend on geometric properties of the grid, such as the cell surface area and volume, which we provide. In addition, one needs only the molecular energy at the grid cell center, circumventing the need for extensive MD simulations and reducing the number of energy evaluations to the number of grid cells. The resulting rate matrix is closely related to the Markov state model transition matrix, offering insights into metastable states and association kinetics. We validate the accuracy of the model in identifying metastable states and binding mechanisms, though improvements are necessary to address limitations like ignoring bulk transitions and anisotropic rotational diffusion. The flexibility of this grid-based method makes it applicable to a variety of molecular systems and energy functions, including those derived from quantum mechanical calculations. The software package MolGri, which implements this approach, offers a systematic and computationally efficient tool for studying molecular association processes.
Stenodera caucasica
Creators: name: Gradinarov, Denis
name: Petrova, Yana
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Meloidae
Stenodera
Stenodera caucasica

description: Stenodera caucasica (Pallas, 1781) (Plate III, 23)
Material examined: Bulgaria, Sakar Mts, W of Ustrem Vill., 42°01.374’N 26°26.975’E, 104 m a.s.l., riverine vegetation, agricultural field boundaries, 03.vii.2022, 1 ♀ (BFUS- MEL000113), D. Gradinarov leg.; Bulgaria, Sakar Mts, N of Yerusalimovo Vill., 41°54.303’N 26°06.074’E, 174 m a.s.l., dirt road, xerothermic grasslands (Fig. 1 B), 26.v.2023, 1 ♀ (BFUS-MEL000114), D. Gradinarov leg.
In the revised edition of the Catalogue of Palaearctic Coleoptera (Bologna 2020), 60 species of Meloidae are listed for Bulgaria. However, firstly reported by Nedelkov (1905) and found also in the present study Apalus bipunctatus, the reported by Angelov (1986) and Siering & Beier (2019) Sitaris muralis (Förster, 1771), as well as Nemognatha chrysomelina (Fabricius, 1775) (Siering et al. 2017), Mylabris olivieri Billberg, 1813 and Euzonitis adustipennis (Motschulsky, 1872) (Siering & Beier 2019) are omitted in the Catalogue. With this inclusion the number of known species of the family Meloidae in Bulgaria is 65.
description: Published as part of Gradinarov, Denis & Petrova, Yana, 2024, Blister beetles (Coleoptera: Meloidae) in Sakar Mountains, Bulgaria, pp. 32-42 in ZooNotes (Suppl 15) (Suppl 15) 2024 on pages 37-38
title: Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice
Creators: name: Schmitz-Peiffer, Fabian
name: Lukas, Mathias
name: Mohan, Ajay-Mohan
name: Albrecht, Jakob
name: Aschenbach, Jörg R.
name: Brenner, Winfried
name: Beindorff, Nicola
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: [99mTc]Tc-MAG3
subject: Single mouse bed
subject: Hotel
subject: Isoflurane concentration
subject: Respiratory rate
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: Background The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using semi-stationary dynamic single photon emission computed tomography (SPECT) for kidney scintigraphy. Therefore, isoflurane concentrations were adjusted using respiratory rate for low (80–90 breath/min) and deep anaesthesia (40–45 breath/min). At low anaesthesia, we additionally tested the influence of single bed versus 3-mouse bed hotel; the hotel mice were anaesthetized consecutively at ~ 30, 20, and 10 min before tracer injections for positions 1, 2, and 3, respectively. Intravenous [ 99m Tc]Tc-MAG3 injection of ~ 28 MBq was performed after SPECT start. Time-activity curves were used to calculate time-to-peak (Tmax), T50 (50% clearance) and T25 (75% clearance). Results Low and deep anaesthesia corresponded to median isoflurane concentrations of 1.3% and 1.5%, respectively, with no significant differences in heart rate ( p  = 0.74). Low anaesthesia resulted in shorter aortic blood clearance half-life ( p  = 0.091) and increased relative renal tracer influx rate ( p  = 0.018). A tendency toward earlier Tmax occurred under low anaesthesia ( p  = 0.063) with no differences in T50 ( p  = 0.40) and T25 ( p  = 0.24). Variance increased with deep anaesthesia. Compared to single mouse scans, hotel mice in position 1 showed a delayed Tmax, T50, and T25 ( p  < 0.05 each). Furthermore, hotel mice in position 1 showed delayed Tmax versus position 3, and delayed T50 and T25 versus position 2 and 3 ( p  < 0.05 each). No difference occurred between single bed and positions 2 ( p  = 1.0) and 3 ( p  = 1.0). Conclusions Deep anaesthesia and prolonged low anaesthesia should be avoided during renal scintigraphy because they result in prolonged blood clearance half-life, delayed renal influx and/or later Tmax. Vice versa, low anaesthesia with high respiratory rates of 80–90 rpm and short duration (≤ 20 min) should be preferred to obtain representative data with low variance.
Piptadenia retusa P. G. Ribeiro, Seigler & Ebinger 2020
Creators: name: Gomes, Aureliana Santos
name: Rodrigues, Erimágna De Morais
name: Moura, Débora Coelho
name: Melo, José Iranildo Miranda De
name: Ribeiro, Rayane De Tasso Moreira
name: Queiroz, Rubens Teixeira De
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Piptadenia
Piptadenia retusa

description: 26. Piptadenia retusa (Jacquin 1760: 34) P.G. Ribeiro, Seigler & Ebinger (2020: 1)
Trees, branches glabrous, aculeate. Nectary petiolar, sessile. Stipules caducous. Leaves bipinnate, paripinnate, 8– 24–foliolate, leaflets opposite, oblong, venation actinodromous, translucid punctuation absent. Inflorescence spike, axillary. Flowers sessile, actinomorphic, diplostemonous; calyx gamosepalous, sepals 5, corolla gamopetalous, tubular, yellow, petals 5; androecium dialystaminous, homodinamous, anthers longitudinal; ovary superior, sessile, pluriovulate. Fruit legume, sessile, linear, plane-corrugate, margin straight, epicarp glabrous, brown. Seeds obovate, plane, coat brown, hilum basal.
Examined material:— BRAZIL. Paraíba: Maturéia, Pico do Jabre, 900 m ele., 06 February 2020, fl., A. Gomes 3147 (HACAM).
Distribution and ecology: — Piptadenia retusa is restricted to the Caatinga phytogeographic domain, being found in the states of Alagoas, Bahia, Ceará, Paraíba, Pernambuco, Piauí, Rio Grande do Norte and Sergipe (Cardoso & Queiroz 2007). In the study area, it was collected in the interior of the forest, at 900 m.
Phenology:— Registered with flower in February.
Taxonomic discussion:— Piptadenia retusa can be recognized, mainly, by the arboreous habit, branches with the presence of aculeous and inflorescences in axillary spike, differentiating itself from the other Mimosa species in the studied area by the presence of extrafloral nectary in the petiole and legume type fruit vs. extrafloral nectary absent and craspédio fruit.
description: Published as part of Gomes, Aureliana Santos, Rodrigues, Erimágna De Morais, Moura, Débora Coelho, Melo, José Iranildo Miranda De, Ribeiro, Rayane De Tasso Moreira & Queiroz, Rubens Teixeira De, 2022, Fabaceae Lindl. in a Conservation Unit in the Semi-Arid Region of Paraíba, Brazil, pp. 17-41 in Phytotaxa 555 (1) on pages 32-33, DOI: 10.11646/phytotaxa.555.1.2, http://zenodo.org/record/6875635
Platymiscium floribundum Vogel 1837
Creators: name: Gomes, Aureliana Santos
name: Rodrigues, Erimágna De Morais
name: Moura, Débora Coelho
name: Melo, José Iranildo Miranda De
name: Ribeiro, Rayane De Tasso Moreira
name: Queiroz, Rubens Teixeira De
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Platymiscium
Platymiscium floribundum

description: 27. Platymiscium floribundum Vogel (1837: 199). (Fig. 3b)
Trees, branches glabrous, inermous. Nectary absent. Stipules interpetiolar, triangular. Leaves imparipinnate, 5– foliolate, leaflets opposite, ovate-elliptic, venation brochidodromous, translucid punctuation absent. Inflorescence raceme, terminal. Flowers pedicellate, zygomorphic, diplostemonous; calyx gamosepalous, sepals 5, corolla dialypetalous, papilionaceous, yellow, petals 5; androecium diadelphous, homodinamous, anthers longitudinal; ovary superior, sessile, pauciovulate. Fruit samara, stipitate, elliptic, plane, margin straight, epicarp glabrous, brown. Seeds elliptic, plane, coat black, hilum central.
Examined material:— BRAZIL. Paraíba: Maturéia, Pico do Jabre, 950 m elev., 23 August 2019, fl., Aureliana Gomes 2080 (HACAM).
Distribution and ecology:— Platymiscium floribundum is an endemic species in Brazil, present in the Northeast, Midwest, Southeast and South regions associated with the domains of the Caatinga, Cerrado and Atlantic Forest (Flora do Brasil 2020). Popularly known as jacarandá do litoral, the species also has records in Bolivia and French Guiana (INCT - Virtual Herbarium of Flora and Fungi).
Phenology:— Registered with flowers in August.
Taxonomic discussion:— Platymiscium floribundum can be recognized, mainly, by the arboreous habit, interpeciolar stipules, leaves opposite, imparipinnate with opposite leaflets, yellow corolla, papilionaceous, samara type fruit and seeds with black coat.
description: Published as part of Gomes, Aureliana Santos, Rodrigues, Erimágna De Morais, Moura, Débora Coelho, Melo, José Iranildo Miranda De, Ribeiro, Rayane De Tasso Moreira & Queiroz, Rubens Teixeira De, 2022, Fabaceae Lindl. in a Conservation Unit in the Semi-Arid Region of Paraíba, Brazil, pp. 17-41 in Phytotaxa 555 (1) on page 33, DOI: 10.11646/phytotaxa.555.1.2, http://zenodo.org/record/6875635
Poecilanthe grandiflora Bentham 1860
Creators: name: Gomes, Aureliana Santos
name: Rodrigues, Erimágna De Morais
name: Moura, Débora Coelho
name: Melo, José Iranildo Miranda De
name: Ribeiro, Rayane De Tasso Moreira
name: Queiroz, Rubens Teixeira De
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Poecilanthe
Poecilanthe grandiflora

description: 28. Poecilanthe grandiflora Bentham (1860: 80). (Fig. 3f)
Trees, branches glabrous, inermous. Nectary absent. Stipules caducous. Leaves imparipinnate, 5–6–foliolate, leaflets alternate, ovate-elliptic, venation brochidodromous, translucid punctuation absent. Inflorescence raceme, terminal. Flowers pedicellate, zygomorphic, diplostemonous; calyx gamosepalous, sepals 5, corolla dialypetalous, papilionaceous, lilac, petals 5; androecium monadelphous, homodinamous, anthers longitudinal; ovary superior, stipitate, pauciovulate. Fruit legume, sessile, oblanceolate, plane, margin straight, epicarp glabrous, brown. Seeds orbicular, plane, coat black, hilum basal.
Examined material:— BRAZIL. Paraíba: Maturéia, Pico do Jabre, 800 m elev., 04 November 2019, fl., Aureliana Gomes 3112 (HACAM).
Distribution and ecology:— The species is endemic to Brazil, registered in the Northeast (AL, BA, CE, MA, PB, PE) and Southeast (MG), associated with the Caatinga and Atlantic Rainforest domains growing in gallery forest, seasonal deciduous forest and semideciduous, in areas of secondary vegetation (Meireles & Tozzi 2007; Flora do Brasil 2020.
Phenology:— Registered with flowers in November.
Taxonomic discussion:— Poecilanthe grandiflora can be recognized, mainly, by the arboreous habit, imparipinnate leaves with alternate leaflets without translucent punctuations, lilac flowers and legume fruit, sessile. Among the Papilionoideae species found in the area, it can be readily recognized for presenting lilac flowers and legume with rigid valves.
description: Published as part of Gomes, Aureliana Santos, Rodrigues, Erimágna De Morais, Moura, Débora Coelho, Melo, José Iranildo Miranda De, Ribeiro, Rayane De Tasso Moreira & Queiroz, Rubens Teixeira De, 2022, Fabaceae Lindl. in a Conservation Unit in the Semi-Arid Region of Paraíba, Brazil, pp. 17-41 in Phytotaxa 555 (1) on page 33, DOI: 10.11646/phytotaxa.555.1.2, http://zenodo.org/record/6875635
Carpophilus (Carpophilus) hemipterus
Creators: name: Gradinarov, Denis
name: Petrova, Yana
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Nitidulidae
Carpophilus
Carpophilus hemipterus

description: Carpophilus (Carpophilus) hemipterus (Linnaeus, 1758)
Material examined: Sakar Mts, Ustrem Vill., 42°01.345’N 26°27.391’E, 95 m a.s.l., street side vegetation (Fig. 1 A, C), 10.ix.2024, 1 ♀ (BFUS-COL000001), emerged 10.ix.– 15.x.2024 from decaying figs, D. Gradinarov & Y. Petrova leg. (Fig. 2 A).
Carpophilus hemipterus is a cosmopolitan species (Jelínek & Audisio 2007) with Paleotropical origin, introduced in the Mediterranean probably in the Roman Age (Jelínek et al. 2016). The species has been repeatedly reported from Bulgaria by various authors (Tomov & Trencheva 2013) but is omitted for the country in the Catalogue of Palaearctic Coleoptera (Jelínek & Audisio 2007).
description: Published as part of Gradinarov, Denis & Petrova, Yana, 2024, Four alien fruit-feeding sap beetle species (Coleoptera: Nitidulidae) from Sakar Mts, Bulgaria, pp. 43-50 in ZooNotes (Supplement 15) (Supplement 15) 2024 on page 44
title: A WHO digital intervention to address depression among young Chinese adults: a type 1 effectiveness-implementation randomized controlled trial
Creators: name: Li, Gen
name: Sit, Hao Fong
name: Chen, Wen
name: Wu, Kunpeng
name: Sou, Elvo Kuai Long
name: Wong, Mek
name: Chen, Ze
name: Burchert, Sebastian
name: Hong, Ieng Wai
name: Sit, Ho Yi
name: Lam, Agnes Iok Fong
name: Hall, Brian J.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Depression
subject: Human behaviour
subject: digital intervention
classificationCode: 150
subject: Psychologie

description: Common mental disorders among young people are rising globally. Current university-based interventions are inadequate to address the need for evidence-based interventions. We investigated the effectiveness and implementation of Step-by-Step (SbS), a WHO digital intervention to address depression, among Chinese university students with depressive symptoms. In this paper, we report a type 1 hybrid effectiveness-implementation randomized controlled trial conducted between September 2021 and September 2022. The control condition was enhanced treatment as usual (ETAU, psychoeducation). The primary outcome was improvement in depression symptoms. Secondary outcomes were improvements in psychological well-being, anxiety symptoms, and self-identified psychosocial problems. Effectiveness of the intervention was evaluated using generalized linear mixed models. Implementation outcomes were evaluated by thematic analysis of participant interviews. A total of 371 participants were enrolled to two treatment conditions in a 1:1 ratio. SbS resulted in a greater reduction in depressive symptoms at posttreatment ( p  = 0.004, Hedges’ g  = 0.35), but no significant difference between SbS and ETAU was observed at three-month follow-up ( p  = 0.179, Hedges’ g  = 0.16). The treatment effect was larger among those who adhered to the treatment (Hedges’ g s = 0.59 and 0.30). Subjective well-being also improved for SbS at both time points (Hedges’ g s = 0.31 and 0.30). In addition, SbS resulted in more improvement in anxiety symptoms at posttreatment ( p  = 0.029, Hedges’ g  = 0.26), but not at three-month follow-up ( p  = 0.265, Hedges’ g  = 0.13). The qualitative results demonstrated that the intervention was well-implemented as a self-help mental health service, with minimal support from peer supporters. In conclusion, Step-by-Step, a digital intervention developed by WHO, was effective in reducing depressive symptoms in the short term and improving psychological well-being in a longer term. The sustained effect on depression needs further investigation. Improving uptake and engagement in the program is needed for its scale-up implementation as a university-based mental health service for Chinese young adults. Trial registration: ChiCTR2100050214.
title: Activité du port de Saint-Malo – 1682 – Brouage
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: épices et condiments

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1682 avec le port "Brouage"
description: Marchandises arrivées à Saint-Malo : sel
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; épices et condiments
description: Coverage: Grand cabotage
description: Bibliographic citation: LANGLET, Philippe. L'activité du port de Saint-Malo de 1681 et 1682. DES : Histoire : Rennes, 1957 (Bibliothèque François-Lebrun - Rennes 2, MH 1000)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Hydroides glandifera Rioja 1941
Creators: name: Bastida-Zavala, J. Rolando
name: Buelna, Alondra Sofía Rodríguez
name: León-González, Jesús Angel De
name: Camacho-Cruz, Karla Andrea
name: Carmona, Isabel
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Sabellida
Serpulidae
Hydroides
Hydroides glandifera

description: Hydroides glandifera Rioja, 1941a
(Figures 5, 11 I)
Hydroides glandiferum Rioja, 1941a: 172 –174, pl. 4, Figs 10 –14. Type locality: Caleta Beach, Acapulco, Guerrero, on rocks, algae and chaetopterid tubes (type specimens lost).
Olgaharmania glandifera Rioja, 1941b: 733 –734 (new genus and new combination); Salazar-Vallejo 1989a: 55 –56 (checklist); Salazar-Vallejo 1989b: 200 (Mexican coasts, checklist); Salazar-Vallejo & Londoño-Mesa 2004: 55 (Tropical Eastern Pacific, checklist).
Hydroides glandiferum.— Salazar-Vallejo 1989b: 199 (Mexican coasts, checklist); Hernández-Alcántara et al. 2008: 48 (mentioned only).
Olgaharmania sp.— Bastida-Zavala 1995: 25 (Cabo Pulmo Reef, Baja California Sur, on coral; 4–17 m).
Hydroides glandifer.—Bastida-Zavala & ten Hove 2003: 89, Figs 12 A–M (Baja California Sur and Jalisco; 4–17 m); Salazar- Vallejo & Londoño-Mesa 2004: 54 (Tropical Eastern Pacific, checklist); Bastida-Zavala 2008: 26, fig. 6J (Oaxaca; 6–10 m); Bastida-Zavala 2009: 536, Fig. 2 H (identification key for Tropical America); ten Hove & Kupriyanova 2009: 53 (worldwide serpulid checklist); Bastida-Zavala et al. 2013: 349 (Oaxaca, checklist); Morales de Anda et al. 2014: 125 (Punta Mita, Nayarit and Navidad Bay, Jalisco; the locality Punta Anita, Jalisco was a mistake in Bastida-Zavala & ten Hove 2003).
Material examined. Three specimens.
Oaxaca: UMAR-POLY 769, 3 spec. (Marina Chahué, Huatulco, on mollusk, May 22, 2000, coll. RBZ).
Habitat. Intertidal to subtidal (17 m, Bastida-Zavala 1995). On mollusk in a dock. Also on dead coral Pocillopora and on spiny oyster Spondylus calcifer (now S. limbatus) (Bastida-Zavala 2008).
Distribution. Mexican Pacific. Baja California Sur to Oaxaca (Bastida-Zavala & ten Hove 2003).
Remarks. From Rioja’s original name Hydroides glandiferum, subsequently changed to Olgaharmania glandifera, it is evident that Rioja intended the specific name to be an adjective which should follow the gender of the genus. Since the genus Hydroides in the meantime is feminine again (ICZN 1999: Art. 30.1.4.4), the correct ending is –a.
Hydroides glandifera is found on corals and mollusks; it is a rare species in the Mexican Pacific.
description: Published as part of Bastida-Zavala, J. Rolando, Buelna, Alondra Sofía Rodríguez, León-González, Jesús Angel De, Camacho-Cruz, Karla Andrea & Carmona, Isabel, 2016, New records of sabellids and serpulids (Polychaeta: Sabellidae, Serpulidae) from the Tropical Eastern Pacific, pp. 401-457 in Zootaxa 4184 (3) on page 422, DOI: 10.11646/zootaxa.4184.3.1, http://zenodo.org/record/255062
title: N2 cleavage by silylene and formation of H2Si(μ-N)2SiH2
Creators: name: Cai, Liyan
name: Xu, Bing
name: Cheng, Juanjuan
name: Cong, Fei
name: Riedel, Sebastian
name: Wang, Xuefeng
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Chemical bonding
subject: Reaction mechanisms
subject: Structure elucidation
classificationCode: 540
subject: Chemie und zugeordnete Wissenschaften

description: Fixation and functionalisation of N2 by main-group elements has remained scarce. Herein, we report a fixation and cleavage of the N ≡ N triple bond achieved in a dinitrogen (N2) matrix by the reaction of hydrogen and laser-ablated silicon atoms. The four-membered heterocycle H2Si(μ-N)2SiH2, the H2SiNN(H2) and HNSiNH complexes are characterized by infrared spectroscopy in conjunction with quantum-chemical calculations. The synergistic interaction of the two SiH2 moieties with N2 results in the formation of final product H2Si(μ-N)2SiH2, and theoretical calculations reveal the donation of electron density of Si to π* antibonding orbitals and the removal of electron density from the π bonding orbitals of N2, leading to cleave the non-polar and strong NN triple bond.
[Apreciados vigías de LA TORRE montevideana: Como por el principio]
Creators: name: Arturo, Carril
name: Carril Arturo
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Vida personal
Amistad
Literatura

description: Destinatario: Somers, Armonía
description: Comentarios varios sobre la pareja y la escritura de Somers.
description: Notas: El intercambio de correspondencia entre Armonía Somers y Arturo Carril se había conservado todo junto. Se ha separado por archivo.
description: Source: Código: AS-B-1981-06-19
description: Source: Localización: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
description: available: Fecha de creación de la reseña: 2020-03-30
title: Pathogenic mutations of human phosphorylation sites affect protein–protein interactions
Creators: name: Rrustemi, Trendelina
name: Meyer, Katrina
name: Roske, Yvette
name: Uyar, Bora
name: Akalin, Altuna
name: Imami, Koshi
name: Ishihama, Yasushi
name: Daumke, Oliver
name: Selbach, Matthias
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Intrinsically disordered proteins
subject: Phosphorylation
subject: Protein–protein interaction networks
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that mediate protein-protein interactions (PPIs), which can be regulated by post-translational modifications like phosphorylation. 20% of pathogenic missense mutations are found in IDRs, and understanding how such mutations affect PPIs is essential for unraveling disease mechanisms. Here, we employ peptide-based interaction proteomics to investigate 36 disease-associated mutations affecting phosphorylation sites. Our results unveil significant differences in interactomes between phosphorylated and non-phosphorylated peptides, often due to disrupted phosphorylation-dependent SLiMs. We focused on a mutation of a serine phosphorylation site in the transcription factor GATAD1, which causes dilated cardiomyopathy. We find that this phosphorylation site mediates interaction with 14-3-3 family proteins. Follow-up experiments reveal the structural basis of this interaction and suggest that 14-3-3 binding affects GATAD1 nucleocytoplasmic transport by masking a nuclear localisation signal. Our results demonstrate that pathogenic mutations of human phosphorylation sites can significantly impact protein-protein interactions, offering insights into potential molecular mechanisms underlying pathogenesis.
Senegalia polyphylla Britton & Rose 1936
Creators: name: Gomes, Aureliana Santos
name: Rodrigues, Erimágna De Morais
name: Moura, Débora Coelho
name: Melo, José Iranildo Miranda De
name: Ribeiro, Rayane De Tasso Moreira
name: Queiroz, Rubens Teixeira De
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Senegalia
Senegalia polyphylla

description: 29. Senegalia polyphylla (De Candolle 1822: 1813) Britton & Rose (1936:142)
Trees, branches glabrescent, aculeate. Nectary petiolar, sessile. Stipules lateral, narrow-triangular. Leaves bipinnate, paripinnate, 8–16–foliolate, leaflets opposite, oblong, venation actinodromous, translucid punctuation absent. Inflorescence glomerule, axillary. Flowers sessile, actinomorphic, polistemonous; calyx gamosepalous, sepals 5, corolla gamopetalous, tubular, whitish, petals 5; androecium dialystaminous, homodinamous, anthers longitudinal; ovary superior, stipitate, pluriovulate. Fruit legume, sessile, linear, plane–corrugate, margin straight, epicarp glabrous, brown. Seeds oblong, plane, coat brown, hilum basal.
Examined material:— BRAZIL. Paraíba: Maturéia, Pico do Jabre, 1.197 m elev., 12 April 2019, fl., Aureliana Gomes 2030 (HACAM).
Distribution and ecology:— The species is distributed in all regions of Brazil associated with the phytogeographic domains of the Amazon, Caatinga, Cerrado, Atlantic Rainforest and Pantanal in areas of seasonal forest, swamps of altitude and restinga (Barros 2011).
Phenology:— Registered with flowers in April.
Taxonomic discussion:— Senegalia polyphylla can be recognized, mainly, by the arboreous habit, branches armed with aculeous, petiolar nectaries, bipinnate leaves, and by the inflorescences in axillary glomerule. Among the species of the Mimosoideae clade, we find species with monadelphous androecium and dialystaminous. The representatives of monadelphous androecium belong to the Ingeae tribe, while those with dialystaminous androecium may belong to the Mimoseae or Acacieae tribes. The androceu-related characteristic used to separate species is the number of stamens; the species of Mimoseae are isosstaminous or diplostaminous whereas those belonging to Acacieae have polistaminous flowers. This species is popularly known as angico branco.
description: Published as part of Gomes, Aureliana Santos, Rodrigues, Erimágna De Morais, Moura, Débora Coelho, Melo, José Iranildo Miranda De, Ribeiro, Rayane De Tasso Moreira & Queiroz, Rubens Teixeira De, 2022, Fabaceae Lindl. in a Conservation Unit in the Semi-Arid Region of Paraíba, Brazil, pp. 17-41 in Phytotaxa 555 (1) on page 34, DOI: 10.11646/phytotaxa.555.1.2, http://zenodo.org/record/6875635
PostCog: A tool for interdisciplinary research into underground forums at scale
Creators: name: Pete, I
name: Hughes, J
name: Caines, A
name: Vu, AV
name: Gupta, H
name: Hutchings, A
name: Anderson, R
name: Buttery, P
Publisher: name: IEEE
Year: 2022
Subjects: cybercrime
forums
interdisciplinary research tools
data analysis

description: Underground forums provide useful insights into cybercrime, where researchers analyse underlying economies, key actors, their discussions and interactions, as well as different types of cybercrime. This interdisciplinary topic of study incorporates expertise from diverse areas, including computer science, criminology, economics, psychology, and other social sciences. Historically, there were significant challenges around access to data, but there are now research datasets of millions of messages scraped from underground forums. The problems now stem from the size of these datasets and the technical nature of methods and tools available for data sampling and analysis at scale, which make data exploration difficult for non-technical users. POSTCOG has been developed to solve this problem. We first provide a survey of prior work into underground forums; this was used to understand the requirements and functionalities valued by researchers, and to inform the design of a data exploration tool. We then describe POSTCOG, a web application developed to support users from both technical and non-technical backgrounds in forum analyses, such as search, information extraction and cross-forum comparison. The prototype’s usability is then evalu- ated through two user studies with expert users of the CRIMEBB dataset. POSTCOG is made available for academic research upon signing an agreement with the Cambridge Cybercrime Centre.
Optimization of high speed bone drilling with automated osteonecrosis avoidance using an ANN-GA hybrid method
Creators: name: Mondal, Nripen
name: Banik, Soumil
name: Burnwal, Shubham Kumar
name: Sarkar, Srija
name: Nandi, Monoranjan
name: Shil, Durba
name: Paul, Ankur
name: Bhadury, Pinaky
name: Mandal, Sudip
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: Efficient high-speed bone drilling with an automated osteonecrosis avoidance strategy is a very fascinating task to the orthopaedic surgeons. Several drilling parameters such as drill diameter, speed, and feed rate can affect the performance of drilling in terms of generated temperature and thrust force. This research is conducted using a high-speed mini CNC machine to investigate bone drilling parameters’ impact on the outputs. Here, a piece of swine bone has been used for testing material and an automated cooling system based on proportional controller (P) was developed to prevent osteonecrosis. Further, a hybrid Artificial Neural Network-Genetic Algorithm (ANN-GA) model has been proposed based on the different experimental findings. ANN predicts output variables, and GA determines the optimal input drilling parameters by minimizing the ANN model of temperature and force. The simulation results revealed that drill diameter of 1.838 mm, speed of 17,880 rpm, and feed rate of 9.973 mm/min minimized the output temperature generated on swine bone. Similarly, diameter of 1.5 mm, speed of 16,582 rpm, and 10 mm/min feed rate helped to minimize the generated force during drilling. The proposed model has been validated by conducting new experiments based on these obtained optimal parameters.
Carpophilus (Carpophilus) marginellus Motschulsky 1858
Creators: name: Gradinarov, Denis
name: Petrova, Yana
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Nitidulidae
Carpophilus
Carpophilus marginellus

description: Carpophilus (Carpophilus) marginellus Motschulsky, 1858
Material examined: Sakar Mts, Ustrem Vill., 42°01.341’N 26°27.385’E, 95 m a.s.l., backyard of a house (Fig. 1 B, D), 07.ix.2024, 1 ♂ (BFUS- COL000002), under decaying figs, after sunset, D. Gradinarov & Y. Petrova leg. (Fig. 2 B, C).
The species C. marginellus is of Paleotropical origin, but presently has a cosmopolitan distribution (Jelínek & Audisio 2007; Jelínek et al. 2016). In Europe, the species was first recorded in Great Britain in 1938 (Denux & Zagatti 2010). For Bulgaria, C. marginellus has been repeatedly cited without specified localities (Jelínek & Audisio 2007; Tomov et al. 2009; Denux & Zagatti 2010; Tomov & Trencheva 2013; Martynov et al. 2019). This species apparently can use a wide range of food sources besides fruits, being found in grains, compost, on tree sap and on flowers (Denux & Zagatti 2010; Martynov et al. 2019).
description: Published as part of Gradinarov, Denis & Petrova, Yana, 2024, Four alien fruit-feeding sap beetle species (Coleoptera: Nitidulidae) from Sakar Mts, Bulgaria, pp. 43-50 in ZooNotes (Supplement 15) (Supplement 15) 2024 on page 44
title: A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin
Creators: name: Drude, Natascha
name: Nagel-Riedasch, Stefan
name: Rosshart, Stephan P.
name: Diefenbach, Andreas
name: Jordan, Stefan
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Microbial communities
subject: Immunology
subject: FOS: Clinical medicine
subject: laboratory mice
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.
Latin Majuscule Writing with semicursive hand in Herculaneum papyri
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 90
description: "Study of the following Latin papyri: P.Herc. 206, 215, 218, 394, 457, 502, 514, 902, 804, 1254, 1257, 1557, 1774. All papyri are listed on the cover page of the main folder, and sometimes they are accompanied by brief bibliographical notes. The indication 'Vu 54 - fini - Revue 58' is written at the end of the list. The study related to each papyrus is enclosed in one folder with the number of the papyrus written on the upper right corner; in one case the sheets related to two papyri are inserted in one single folder, and one of the two numbers is written in a different ink"
description: Source: 4MAR_9_2_5-15
description: created: n.d., 1957
Ototylomys chiapensis Porter et al. 2017
Creators: name: Don E. Wilson
name: Russell A. Mittermeier
name: Thomas E. Lacher, Jr
Publisher: name: Lynx Edicions
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Ototylomys
Ototylomys chiapensis

description: 758.
La Pera Climbing Rat
Ototylomys chiapensis
French: Tylomys de La Pera / German: La-Pera-Kletterratte / Spanish: Rata trepadora de La Pera
Other common names: La Pera Big-eared Climbing Rat
Taxonomy. Ototylomys chiapensis Porter et al., 2017, “Pozo de Petroleo, 11 km northwest (by road) Berriozabal, L.a Pera Conservation Area, Chiapas, Mexico.”
Ototylomys chiapensis is strongly differentated morphologically from O. phyllotis and might represent a new genus. Monotypic.
Distribution. Known only from two localities in Chiapas (El Ocote Biosphere Reserve and La Pera Conservation Area), Mexico.
Descriptive notes. Head—body 139-194 mm, tail 135-174 mm, ear 20-27 mm, hindfoot 30-34 mm; weight 55-165 g (mean 103 g). The La Pera Climbing Rat is slightly larger than the Big-eared Climbing Rat (O. phyllotis). Dorsum is brown, with irregular and indistinct rust-colored patches medially. Venter has white patches in pectoral and inguinal regions and is mottled tan-brown. Tail is long and scaly and appears hairless. Ears are hairless, broad, oval, thin, and translucent. Hindfeet are long. Chromosomal complement is 2n = 48, FN = 84, with 19 pairs of biarmed chromosomes and four acrocentric pairs.
Habitat. Montane karst rainforests at elevations of ¢.700-1100 m.
Food and Feeding. Captive La Pera Climbing Rats eat sunflower seeds but rarely fresh fruit.
Breeding. Female La Pera Climbing Rats collected in December had no reproductive signals. Two females that were pregnant when caught each produced single offspring in captivity.
Activity patterns. No information.
Movements, Home range and Social organization. No information.
Status and Conservation. Not assessed on The IUCN Red List. Based on area of occupancy and potential reduction in extent and quality of habitat, the La Pera Climbing Rat likely qualifies as Critically Endangered.
Bibliography. Porter et al. (2017), Rogers et al. (2005).
description: Published as part of Don E. Wilson, Russell A. Mittermeier & Thomas E. Lacher, Jr, 2017, Cricetidae, pp. 204-535 in Handbook of the Mammals of the World – Volume 7 Rodents II, Barcelona :Lynx Edicions on page 534, DOI: 10.5281/zenodo.6707142
Senna angulata H. S. Irwin & Barneby 1982
Creators: name: Gomes, Aureliana Santos
name: Rodrigues, Erimágna De Morais
name: Moura, Débora Coelho
name: Melo, José Iranildo Miranda De
name: Ribeiro, Rayane De Tasso Moreira
name: Queiroz, Rubens Teixeira De
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Senna
Senna angulata

description: 30. Senna angulata H.S.Irwin & Barneby (1982: 177)
Shrubs erect, branches tomentose, inermous. Nectary rachis, stipitate. Stipules lateral, acicular. Leaves paripinnate, 4– foliolate, leaflets opposite, lanceolate, venation brochidodromous, translucid punctuation absent. Inflorescence raceme, terminal. Flowers pedicillate, zygomorphic, diplostemonous; calyx dialysepalous, sepals 5, corolla dialypetalous, yellow, petals 5; androecium dialystaminous, heterodinamous, anthers poricidal; ovary superior, stipitate, pluriovulate. Fruit berry, stipitate, linear, cylindric, margin straight, epicarp tomentulose, black. Seeds obovate, plane, coat black, hilum basal.
Examined material:— BRAZIL. Paraíba: Maturéia, Pico do Jabre, 1.000 m elev., 12 April 2019, fl. Aureliana Gomes 2015 (HACAM).
Distribution and ecology:— The species is endemic to Brazil, with records in the states of Bahia, Espírito Santo, Minas Gerais, Rio de Janeiro, São Paulo, Paraná and Santa Catarina associated with the Cerrado and Atlantic Rainforest domains in areas of ombrophilous and seasonal forest (Tozzi 2016).
Phenology:— Registered with flowers in April.
Taxonomic discussion:— Senna angulata can be recognized, mainly, by the shrub habit, 4-leaflet leaves and inflorescence in terminal raceme, with yellow corolla flowers, heterodinamous androecium, poricidal anthers and bacoid fruit. Senna species found in the studied area have 4–leaflet leaves, except Senna martina and S. obtusifolia, which have a higher number of leaflets. Among the representatives of Senna 4–leaftles, S. angulata is the one with the largest size, which can be confused with Senna macranthera. However, the first is an erect shrub, while the second is a scandant shrub.
description: Published as part of Gomes, Aureliana Santos, Rodrigues, Erimágna De Morais, Moura, Débora Coelho, Melo, José Iranildo Miranda De, Ribeiro, Rayane De Tasso Moreira & Queiroz, Rubens Teixeira De, 2022, Fabaceae Lindl. in a Conservation Unit in the Semi-Arid Region of Paraíba, Brazil, pp. 17-41 in Phytotaxa 555 (1) on page 34, DOI: 10.11646/phytotaxa.555.1.2, http://zenodo.org/record/6875635
title: Evidence-based health messages increase intention to cope with loneliness in Germany: a randomized controlled online trial
Creators: name: Liu, Shuyan
name: Haucke, Matthias
name: Wegner, Luisa
name: Gates, Jennifer
name: Bärnighausen, Till
name: Adam, Maya
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Education
subject: Quality of life
subject: loneliness
classificationCode: 150
subject: Psychologie

description: Loneliness poses a formidable global health challenge in our volatile, post-pandemic world. Prior studies have identified promising interventions to alleviate loneliness, however, little is known about their effectiveness. This study measured the effectiveness of educational entertainment (“edutainment”) and/or evidence-based, written health messages in alleviating loneliness and increasing intention to cope with loneliness. We recruited 1639 German participants, aged 18 years or older. We compared three intervention groups who received: (A) edutainment and written health messages, (B) only edutainment, or (C) only written health messages, against (D) a control group that received nothing. The primary outcomes were loneliness and intention to cope with loneliness. Participants were also invited to leave comments about the interventions or about their perception or experiences with loneliness. We found a small ( d  = 0.254) but significant effect of the written messages on increased intention to cope with loneliness ( b  = 1.78, t (1602) = 2.91, P  = 0.004), while a combination of edutainment and written messages significantly decreased loneliness scores ( b  = −0.25, t (1602) = −2.06, P  = 0.04) when compared with the control, even after adjusting for covariables including baseline values, self-esteem, self-efficacy, and hope. We also observed significantly higher self-esteem scores after exposure to a combination of edutainment and written messages ( b  = 0.821, t (1609) = 1.76, one-tailed P  = 0.039) and significantly higher hope scores after exposure to edutainment-only ( b  = 0.986, t (1609) = 1.85, one-tailed P  = 0.032) when compared with the control group. Our study highlights the benefits of using written messages for increasing intention to cope with loneliness and a combination of edutainment and written messages for easing loneliness. Even in small “doses” (less than 6 min of exposure), edutainment can nurture hope, and edutainment combined with written messages can boost self-esteem.
Annotations on P.Oxy VIII 1073.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 5
description: Descriptions, transcription, palaeographical study.
description: Source: 4MAR_19_3.1-2
description: created: n. d.
title: Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy
Creators: name: Escobar, Helena
name: Di Francescantonio, Silvia
name: Smirnova, Julia
name: Graf, Robin
name: Müthel, Stefanie
name: Marg, Andreas
name: Zhogov, Alexej
name: Krishna, Supriya
name: Metzler, Eric
name: Petkova, Mina
name: Daumke, Oliver
name: Kühn, Ralf
name: Spuler, Simone
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: CRISPR-Cas9 genome editing
subject: Molecular medicine
subject: Muscle stem cells
subject: Neuromuscular disease
subject: Targeted gene repair
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Dystrophy-associated fer-1-like protein (dysferlin) conducts plasma membrane repair. Mutations in the DYSF gene cause a panoply of genetic muscular dystrophies. We targeted a frequent loss-of-function, DYSF exon 44, founder frameshift mutation with mRNA-mediated delivery of SpCas9 in combination with a mutation-specific sgRNA to primary muscle stem cells from two homozygous patients. We observed a consistent >60% exon 44 re-framing, rescuing a full-length and functional dysferlin protein. A new mouse model harboring a humanized Dysf exon 44 with the founder mutation, hEx44mut, recapitulates the patients’ phenotype and an identical re-framing outcome in primary muscle stem cells. Finally, gene-edited murine primary muscle stem-cells are able to regenerate muscle and rescue dysferlin when transplanted back into hEx44mut hosts. These findings are the first to show that a CRISPR-mediated therapy can ameliorate dysferlin deficiency. We suggest that gene-edited primary muscle stem cells could exhibit utility, not only in treating dysferlin deficiency syndromes, but also perhaps other forms of muscular dystrophy.
title: Lieschgras :
title: Richtlinien für die Durchführung der Prüfung auf Unterscheidbarkeit, Homogenität und Beständigkeit.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2020

description: Zweck dieser Richtlinien („Prüfungsrichtlinien“) ist es, die in der Allgemeinen Einführung (Dokument TG/1/3) und deren verbundenen TGP-Dokumenten enthaltenen Grundsätze in detaillierte praktische Anleitung für die harmonisierte Prüfung der Unterscheidbarkeit, der Homogenität und der Beständigkeit (DUS) umzusetzen und insbesondere geeignete Merkmale für die DUS-Prüfung und die Erstellung harmonisierter Sortenbeschreibungen auszuweisen.
title: A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses
Creators: name: Soh, Timothy K.
name: Ognibene, Sofia
name: Sanders, Saskia
name: Schäper, Robin
name: Kaufer, Benedikt B.
name: Bosse, Jens B.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Herpes virus
subject: Molecular modelling
subject: homology
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Structure predictions have become invaluable tools, but viral proteins are absent from the EMBL/DeepMind AlphaFold database. Here, we provide proteome-wide structure predictions for all nine human herpesviruses and analyze them in depth with explicit scoring thresholds. By clustering these predictions into structural similarity groups, we identified new families, such as the HCMV UL112-113 cluster, which is conserved in alpha- and betaherpesviruses. A domain-level search found protein families consisting of subgroups with varying numbers of duplicated folds. Using large-scale structural similarity searches, we identified viral proteins with cellular folds, such as the HSV-1 US2 cluster possessing dihydrofolate reductase folds and the EBV BMRF2 cluster that might have emerged from cellular equilibrative nucleoside transporters. Our HerpesFolds database is available at https://www.herpesfolds.org/herpesfolds and displays all models and clusters through an interactive web interface. Here, we show that system-wide structure predictions can reveal homology between viral species and identify potential protein functions.