cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On-sky demonstration at Palomar Observatory of the near-IR, high-resolution VIPA spectrometer
Creators: name: Carlotti, Alexis
name: Bidot, Alexis
name: Mouillet, David
name: Correia, Jean-Jacques
name: Jocou, Laurent
name: Curaba, Stéphane
name: Delboulbé, Alain
name: Coarer, Etienne Le
name: Rabou, Patrick
name: Bourdarot, Guillaume
name: Forveille, Thierry
name: Bondils, Xavier
name: Vasisht, Gautam
name: Mawet, Dimitri
name: Burruss, Rick S.
name: Oppenheimer, Rebecca
name: Doyon, René
name: Artigau, Etienne
name: Vallée, Philippe
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A near-IR high-resolution, R=80000 spectrometer has been developed at IPAG to directly characterize the atmosphere of exoplanets using adaptive optics (AO) assisted telescopes, and a single-mode fiber-injection unit. A first technical test with the 200' Hale telescope at Palomar Observatory occurred in March 2022 using the PALM3000 AO system offered by this telescope. Observations have also been made at the same time with the PARVI spectrometer so that a direct comparison can be made between the two instruments. This spectrometer uses a virtually imaged phased array (VIPA) instead of an echelle grating, resulting in a very compact optical layout that fits in a 0.25m3 cryostat. Using a quarter of an H2RG detector, the spectrometer analyses the middle part of the H-band, from 1.57 to 1.7 microns for 2 sources whose light is transferred from the telescope to the spectrometer using single-mode fibers. By design, the transmission of the spectrometer is expected to be 40-50%, which is 2-3 times higher than the transmission of current high-resolution spectrometers such as CRIRES+ and NIRSPEC. A damaged cross-disperser limited it to 21%, however. A replacement grating with a correct, twice as high efficiency has been procured after the on-sky demonstration. In addition to recalling the main specifications of the VIPA spectrometer, this paper presents the control software, the calibration process, and the reduction pipeline that have been developed for the instrument. It also presents the results of the on-sky technical test with the Hale telescope, as well as measurements of the effective resolution and transmission, along with a comparison of a spectrum of the sun obtained with the spectrometer with the BASS2000 reference spectrum. Planned modifications are also discussed. That includes the integration of a new dedicated H2RG detector, and of K-band optics.
The tubulin code in vascular dementia and Alzheimer’s disease
Creators: name: Santiago Mugica, Estibaliz
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: Vascular dementia and Alzheimer’s disease are the two most common forms of dementia. While vascular dementia is caused by reduced blood flow to the brain, Alzheimer’s disease patients have amyloid and tau protein deposits in their brain. Although these two dementias have different etiologies, they share some similarities in their pathophysiology, such as altered hemodynamics, morphological and cellular changes, including synaptic proteins loss. This thesis builds on a previous work that reported a non-significant decrease of tubulin together with a loss of neuronal cell volume with loss of soluble tau protein in the temporal, but not the frontal cortex of patients with vascular dementia. In this thesis, we hypothesise that molecular changes in tubulin may result in changes in other cytoskeletal proteins and precede the neuronal cell loss observed in dementia. To further explore this hypothesis, this thesis studies not only various isotypes of tubulin, but also several post-translational modifications of tubulin. In addition, the level of microtubule associated proteins were also quantified, and the processes of regeneration and degeneration investigated. This thesis provides evidence of a distinct pattern in the level of tubulin depending on the isotype and dementia being studied. Furthermore, we show that VaD patients show significantly lower levels of tyrosinated tubulin in the frontal lobe when compared to controls. We also found lower levels of tau and MAPA2 in the frontal lobe of Alzheimer’s disease patients when compared to controls, together with lower levels of MAP6 in both vascular dementia and Alzheimer’s disease subjects in the temporal lobe.
Anthropomorphe Gefäße der Theißkultur von der Siedlung Kökénydomb bei Hódmezővásárhely (Ungarn)
Creators: name: Banner, János
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: -
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 37, Nr. 1/4 (1959)
Chemostratigraphy of the extrusive sequence of a Late Cretaceous Neotethyan ophiolite in Southern Iran and its significance for the mode and tempo of subduction initiation magmatism and melt evolution in forearc tectonic settings
Creators: name: Shafaii Moghadam, Hadi
name: Dilek, Yildirim
name: Furnes, Harald
name: Ishizuka, Osamu
name: Chiaradia, Massimo
name: Li, Qiu-li
name: Karsli, Orhan
name: Lucci, Federico
name: Asadi, Ali
Publisher: name: Geological Society of London
Year: 2023
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Fig. S3.
Racial disparities in treatment patterns, healthcare resource use, and outcomes in patients with pulmonary arterial hypertension in the United States
Creators: name: Melendres-Groves, Lana
name: Tang, Wenze
name: Germack, Hayley D.
name: Liu, Zhiwen
name: Sadik, Kay
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: This retrospective study using claims data compared demographics, clinical characteristics, treatment patterns, healthcare resource utilization, and clinical outcomes in Black and White patients with pulmonary arterial hypertension (PAH) in the United States. Patients (aged ≥18 years) had ≥1 pharmacy claim for PAH medication, ≥6 months’ continuous healthcare plan enrollment, ≥1 inpatient/outpatient medical claim with a pulmonary hypertension diagnosis ≤6 months before first PAH medication, and race recorded. This analysis included 836 Black and 2896 White patients. Black patients were younger, with lower levels of education and annual household income, and higher comorbidity scores versus White patients. Only ∼14% of Black and White patients received index combination therapy. Lower adherence to index treatment was observed in Black patients. Although adjusted regression analysis in the overall population showed no differences in outcomes between groups, Black patients <65 years were 36% less likely to receive index combination therapy (odds ratio [OR] 0.64; 95% confidence interval [CI] 0.41–0.99), and 46% less likely to adhere to index treatment (OR 0.54; 95% CI 0.33–0.90). Other disparities included 24% higher all-cause health care resource utilization, 75% higher all-cause costs, and higher risk of clinical composite outcome. Social determinants of health (education, income, health insurance plan) partially mediated these race effects. Differences in demographics, clinical characteristics, and treatment patterns between Black and White patients with PAH were observed. Disparities between Black and White patients <65 years were only partially mediated through social determinants of health variables, suggesting other factors may be involved.
Additional file 1 of Anopheles diversity, biting behaviour and transmission potential in forest and farm environments of Gia Lai province, Vietnam
Creators: name: Van Dung, Nguyen
name: Thieu, Nguyen Quang
name: Canh, Hoang Dinh
name: Le Duy, Bui
name: Hung, Vu Viet
name: Ngoc, Nguyen Thi Hong
name: Mai, Nguyen Vu Tuyet
name: Van Anh, Ngo Thi
name: Son, Le Duy
name: Oo, Win Han
name: Htike, Win
name: Oo, May Chan
name: Galau, Naw Hkawng
name: Thu, Kaung Myat
name: Zaw, Aung Khine
name: Htwe, Ei Phyu
name: Cutts, Julia C.
name: Kearney, Ellen A.
name: Wang, Bangyuan
name: Agius, Paul A.
name: Fowkes, Freya J. I.
name: O’Flaherty, Katherine
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
classificationCode: 60506
subject: Virology

description: Additional file 1: Table S1. qPCR primer and probe sequences for Plasmodium spp. detection. Table S2. qPCR assay specifications. Table S3. Genus composition of collected mosquitoes (n). Table S4. Species and trapping method of specimens analysed by PCR and diffused serum agglutination. Figure S1. Location of Gia Lai Province, Vietnam, and location of Ia Dom and Ia Mlah communes within Duc Co and Krong Pa Districts, Gia Lai Province. Figure S2. Number of Anopheles mosquitoes collected nightly by HDNT in farm and forest sites in Krong Pa District by species. Each connected line represents a separate collection night. Figure S3. Number of Anopheles mosquitoes collected nightly by HDNT in farm and forest sites in Krong Pa District by species. Each connected line represents a separate collection night.
Prevalence of non-stationarity in quasi-periodic pulsations (QPPs) associated with M- and X-class solar flares
Creators: name: Mehta, Tishtrya
name: Broomhall, Anne-Marie
name: Hayes, Laura
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Quasi-periodic pulsations (QPPs) are frequently observed in solar and stellar flare emission, with recent studies suggesting that an increasing instantaneous period is a common characteristic of QPPs. Determining the prevalence of non-stationarity in QPPs contributes to a better understanding of which mechanisms are responsible in QPP generation. We obtain the rate of period evolution from QPPs in 98 M- and X-class flares from Solar Cycle 24 with average periods between 8-130s and investigate the prevalence of QPP non-stationarity. We also investigate whether the presence of a Coronal Mass Ejection (CME) impacts the period evolution of QPPs. We analyse soft X-ray lightcurves obtained from GOES' X-Ray Sensor (XRS) and assess the dominant periods in the impulsive and decay phases of the flares using the Fast Fourier Transform. We relate the rate of period evolution to flare duration, peak flare energy, and average QPP period. We find evidence of non-stationarity in 81% of the flares assessed, with most QPPs exhibiting a period evolution of less than 10s between the impulsive and decay phases, of which 66% exhibited an apparent period growth and 14% showed an apparent period shrinkage. We find a positive correlation between the absolute magnitude of period evolution and the duration of the flare and no correlation between the period evolution of the QPPs and flare energy or CME presence. Furthermore, we conclude that non-stationarity is common in solar QPPs and must be accounted for in flare analysis.
description: 10 pages, 11 figures, 1 table
Real-world effectiveness and safety of macitentan in patients with pulmonary artery hypertension: a multicenter, retrospective, observational study in China
Creators: name: Chen, Yu-Cheng
name: Dai, Hai-Long
name: Liu, Chun-Li
name: Li, Jiang
name: Ji, Qiu-Shang
name: Cao, Yun-Shan
name: Xiao, Jing
name: Jian, Rong
name: Zhuo, Jian-Min
name: Luo, Xin-Chao
name: Gu, Hong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Macitentan, either as monotherapy or part of combination therapy, improved clinical outcomes in patients with pulmonary artery hypertension (PAH) in clinical trials. Evidence on the effectiveness and safety of macitentan administered in real-world clinical practice in China is limited. This real-world, retrospective, multicenter chart review study was conducted at seven hospitals in China. Adult patients with a diagnosis of PAH who initiated macitentan and had medical assessments at 3–7 months after macitentan initiation were included. The primary outcomes were changes in the World Health Organization functional class (WHO-FC), 6-min walk distance (6MWD), and N-terminal pro-B-type natriuretic peptide (NT-proBNP)/B-type natriuretic peptide from baseline to first follow-up visit (months 3–7). Serious adverse events (SAEs) and adverse drug reactions (ADRs) of macitentan were collected. From 30 August 2021 to 31 March 2022, 214 eligible patients were included in the safety analysis set and 105 patients were included in the analysis of effectiveness. At the first follow-up visit compared with baseline, significant changes in WHO-FC were observed (p = .04), 93.5% patients had their WHO-FC improved (25.8%) or maintained (67.7%). 6MWD changed by a mean (standard deviation [SD]) of 45.0 (81.4) meters (p < .001), with 94.7% having their 6MWD improved (34.7%) or maintained (60.0%). The mean (SD) of NT-proBNP decreased from 1667.4 (3233.0) ng/L to 1090.0 (2230.1) ng/L (p < .001). In the safety analysis set, 24 (11.2%) patients experienced at least one ADR and/or SAE. ADRs and SAEs were reported in 11 (5.1%) and 18 (8.4%), respectively. No deaths or unexpected safety events were observed. This study provided real-world evidence on the clinical benefits and good tolerance of macitentan in Chinese patients with PAH treated in routine clinical practice.
Towards Monocular Shape from Refraction
Creators: name: Sulc, Antonin
name: Sato, Imari
name: Goldluecke, Bastian
name: Treibitz, Tali
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Refraction is a common physical phenomenon and has long been researched in computer vision. Objects imaged through a refractive object appear distorted in the image as a function of the shape of the interface between the media. This hinders many computer vision applications, but can be utilized for obtaining the geometry of the refractive interface. Previous approaches for refractive surface recovery largely relied on various priors or additional information like multiple images of the analyzed surface. In contrast, we claim that a simple energy function based on Snell's law enables the reconstruction of an arbitrary refractive surface geometry using just a single image and known background texture and geometry. In the case of a single point, Snell's law has two degrees of freedom, therefore to estimate a surface depth, we need additional information. We show that solving for an entire surface at once introduces implicit parameter-free spatial regularization and yields convincing results when an intelligent initial guess is provided. We demonstrate our approach through simulations and real-world experiments, where the reconstruction shows encouraging results in the single-frame monocular setting.
description: 12 pages, 6 figures, The 32nd British Machine Vision Conference (BMVC)
Cosmological Perturbations in Restricted f(R)-Gravity
Creators: name: Chaichian, M.
name: Ghalee, A.
name: Kluson, J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the metric perturbations of the restricted f(R) theory of gravity in the cosmological context and explore the phenomenological implications of this model. We show that it is possible to construct a restricted model of gravity, in which the background equations are the same as the equations of motion which are derived from the Einstein-Hilbert action with the cosmological constant term. We argue that the deviation from the Einstein-Hilbert model emerges in the perturbed equations, for which we have a non-vanishing anisotropic stress. Further, with the help of the results of Planck data for the modified gravity we obtain constraints on the parameters of the model.
description: 15 pages
Chemostratigraphy of the extrusive sequence of a Late Cretaceous Neotethyan ophiolite in Southern Iran and its significance for the mode and tempo of subduction initiation magmatism and melt evolution in forearc tectonic settings
Creators: name: Shafaii Moghadam, Hadi
name: Dilek, Yildirim
name: Furnes, Harald
name: Ishizuka, Osamu
name: Chiaradia, Massimo
name: Li, Qiu-li
name: Karsli, Orhan
name: Lucci, Federico
name: Asadi, Ali
Publisher: name: Geological Society of London
Year: 2023
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Fig. S1.
Comparative efficacy of ciltacabtagene autoleucel versus idecabtagene vicleucel in the treatment of patients with relapsed or refractory multiple myeloma previously treated with 2–4 prior lines of therapy: a matching-adjusted indirect comparison
Creators: name: Bar, Noffar
name: Diels, Joris
name: van Sanden, Suzy
name: Mendes, João
name: Hernando, Teresa
name: Burnett, Heather
name: Cost, Patricia
name: Schecter, Jordan M.
name: Lendvai, Nikoletta
name: Patel, Nitin
name: Ishida, Tadao
name: Er, Jeremy
name: Harrison, Simon J.
name: Lopez-Muñoz, Nieves
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: To estimate the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus idecabtagene vicleucel (ide-cel) in patients with relapsed/refractory multiple myeloma (RRMM) treated with 2–4 prior lines of therapy. Matching adjusted indirect comparison (MAICs) were performed using individual patient-level data (IPD) for cilta-cel from CARTITUDE-1 and CARTITUDE-4 and published aggregated data for ide-cel from KarMMa-3. Cilta-cel patients who met inclusion criteria from KarMMa-3 were selected, and outcomes were compared against data for ide-cel using simulated IPD derived from aggregate-level data from KarMMa-3. Patient characteristics were adjusted by reweighting cilta-cel IPD to match the distribution of prognostic factors in KarMMa-3. Comparative efficacy was estimated for response outcomes using a weighted logistic regression analysis and for progression-free survival using a weighted Cox proportional hazards model. Patients treated with cilta-cel were 1.2 times more likely to achieve overall response (relative response ratio [RR]: 1.18 [95% confidence interval: 1.03–1.34]; p = 0.04), 1.3 times more likely to achieve very good partial response or better (RR: 1.34 [1.15–1.57]; p = 0.003), and 1.9 times more likely to achieve complete response or better (RR: 1.91 [1.54–2.37]; p < 0.0001) versus ide-cel patients from KarMMa-3. Cilta-cel was associated with a significant 49% reduction in risk of disease progression or death versus ide-cel (hazard ratio: 0.51 [95% confidence interval: 0.31, 0.84]; p = 0.0078). For patients with triple-class exposed RRMM treated with 2–4 prior lines of treatment, cilta-cel was found to provide superior clinical benefit over ide-cel in terms of response and progression-free survival.
Neolithische Tonspinnwirtel aus Ufersiedlungen des Bodensees
Creators: name: Maier, Rudolf Albert
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: -
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 37, Nr. 1/4 (1959)
Perturbation theory for short-range weakly-attractive potentials in one dimension
Creators: name: Amore, Paolo
name: Fernández, Francisco M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We have obtained the perturbative expressions up to sixth order for the energy of the bound state in a one dimensional, arbitrarily weak, short range finite well, applying a method originally developed by Gat and Rosenstein Ref. [3]. The expressions up to fifth order reproduce the results already known in the literature, while the sixth order had not been calculated before. As an illustration of our formulas we have applied them to two exactly solvable problems and to a nontrivial problem.
description: 12 pages, 1 figure
Die Gliederung des böhmischen und mährischen Jungneolithikums als forschungsgeschichtliches Problem
Creators: name: Driehaus, Jürgen
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: -
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 37, Nr. 1/4 (1959)
Modelling the effect of acoustic waves on nucleation
Creators: name: Haqshenas, S. R.
name: Ford, I. J.
name: Saffari, N.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A phase transformation in a metastable phase can be affected when it is subjected to a high intensity ultrasound wave. In this study we determined the effect of oscillation in pressure and temperature on a phase transformation using the Gibbs droplet model in a generic format. The developed model is valid for both equilibrium and non-equilibrium clusters formed through a stationary or non-stationary process. We validated the underlying model by comparing the predicted kinetics of water droplet formation from the gas phase against experimental data in the absence of ultrasound. Our results demonstrated better agreement with experimental data in comparison with classical nucleation theory. Then, we determined the thermodynamics and kinetics of nucleation and the early stage of growth of clusters in an isothermal sonocrystallisation process. This new contribution shows that the effect of pressure on the kinetics of nucleation is cluster size-dependent in contrast to classical nucleation theory.
Additional file 1 of Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
Creators: name: Bellanti, Francesco
name: Kasperczyk, Sławomir
name: Kasperczyk, Aleksandra
name: Dobrakowski, Michał
name: Pacilli, Gabriella
name: Vurchio, Giuseppina
name: Maddalena, Alessandro
name: Quiete, Stefano
name: Lo Buglio, Aurelio
name: Capurso, Cristiano
name: Serviddio, Gaetano
name: Vendemiale, Gianluigi
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy
classificationCode: 111714
subject: Mental Health
subject: Hematology

description: Additional file 1: Fig. S1. Enrollment and stratification of study participants. Fig. S2. mRNA expression of superoxide dismutase, catalase, glutathione peroxidaseand glutathione-S-transferasein peripheral blood mononuclear cells from patients enrolled in the study, grouped according to the diagnosis of COVID-19. Fig. S3. Collagen-induced platelet aggregation in patients enrolled in the study, grouped according to the diagnosis of COVID-19. Table S1. Clinical characteristics of patients enrolled in the study, grouped according to the diagnosis of COVID-19. Table S2. Pharmacotherapy of patients enrolled in the study, grouped according to the diagnosis of COVID-19. Table S3. Baseline arterial blood gas measurements in patients enrolled in the study, grouped according to the diagnosis of COVID-19. Table S4. Baseline biochemical characteristics, markers of systemic inflammation and circulating cytokines in patients enrolled in the study, grouped according to the diagnosis of COVID-19.
Titel
Creators: name: Redaktion, Die
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 37, Nr. 1/4 (1959)
Safety and effectiveness of vortioxetine in patients with major depressive disorder in a real-life clinical setting in India: results from an interventional, flexible-dose study
Creators: name: Adair, Michael
name: Bose, Rohini
name: Schmidt, Simon Nitschky
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Virology

description: Vortioxetine has demonstrated safety and efficacy in improving symptoms of major depressive disorder (MDD), including overall functioning in real-world settings. This is the first study in a real-life clinical setting in India to evaluate effectiveness and safety of vortioxetine in patients with MDD. This interventional, open-label study consisted of a 12-week treatment period with flexible doses of vortioxetine (5–20 mg/day) in adult patients (aged 18–65 years) with a confirmed MDD diagnosis. Effectiveness outcomes included change from baseline to week 12 in Patient Health Questionnaire-9 (PHQ-9) and Clinical Global Impression–Severity (CGI-S) scores, along with CGI-Improvement (CGI-I) scores at week 12, using a mixed model for repeated measures. Adverse events (AEs) were recorded for safety outcome assessments. Of 395 patients who received vortioxetine, 42.3% were women mean age 38.9 years; 322 patients completed the study. Significant improvement in depressive symptoms was observed in change from baseline to week 12 least squares (LS) mean (SE) PHQ-9 total score (−9.36 [0.276]; p<.0001) and CGI-S score (−2.14 [0.065]; p<.0001). LS mean (SE) CGI-I score showed significant improvement at week 12 (1.93 [0.067]; p<.0001). Subgroup analysis across age, sex, disease severity, and body mass index showed significant improvements in depression symptoms and severity. A total of 35.4% (n = 140) of patients experienced treatment-emergent AEs (mostly mild-moderate); nausea and pruritus were the most frequent (6.6%, n = 26 each). Safety and effectiveness of vortioxetine in improving symptoms of MDD over a 12-week period was demonstrated in a real-life clinical setting in India. Open-label, flexible-dose study of vortioxetine in patients with major depressive disorder in India; Clinical Trials.gov ID: NCT04288895; https://www.clinicaltrials.gov/study/NCT04288895
Analytic next-to-nearest neighbour XX models with perfect state transfer and fractional revival
Creators: name: Christandl, Matthias
name: Vinet, Luc
name: Zhedanov, Alexei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81P45, 33C45

description: Certain non-uniformly coupled spin chains can exhibit perfect transfer of quantum states from end to end. Motivated by recent experimental implementations, we extend the simplest such chain to next-to-nearest neighbour (NNN) couplings. It is shown analytically that perfect state transfer can be maintained under the extension and that end-to-end entanglement generation (fractional revival) can occur.
description: 12 pages
A proof of Friedman's ergosphere instability for scalar waves
Creators: name: Moschidis, Georgios
Publisher: name: arXiv
Year: 2016
Subjects: subject: Analysis of PDEs (math.AP)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Let $(\mathcal{M}^{3+1},g)$ be a real analytic, stationary and asymptotically flat spacetime with a non-empty ergoregion $\mathscr{E}$ and no future event horizon $\mathcal{H}^{+}$. On such spacetimes, Friedman provided a heuristic argument that the energy of certain solutions $ϕ$ of $\square_{g}ϕ=0$ grows to $+\infty$ as time increases. In this paper, we provide a rigorous proof of Friedman's instability. Our setting is, in fact, more general. We consider smooth spacetimes $(\mathcal{M}^{d+1},g)$, for any $d\ge2$, not necessarily globally real analytic. We impose only a unique continuation condition for the wave equation across the boundary $\partial\mathscr{E}$ of $\mathscr{E}$ on a small neighborhood of a point $p\in\partial\mathscr{E}$. This condition always holds if $(\mathcal{M},g)$ is analytic in that neighborhood of $p$, but it can also be inferred in the case when $(\mathcal{M},g)$ possesses a second Killing field $Φ$ such that the span of $Φ$ and the stationary Killing field $T$ is timelike on $\partial\mathscr{E}$. We also allow the spacetimes $(\mathcal{M},g)$ under consideration to possess a (possibly empty) future event horizon $\mathcal{H}^{+}$, such that, however, $\mathcal{H}^{+}\cap\mathscr{E}=\emptyset$ (excluding, thus, the Kerr exterior family). As an application of our theorem, we infer an instability result for the acoustical wave equation on the hydrodynamic vortex, a phenomenon first investigated numerically by Oliveira, Cardoso and Crispino. Furthermore, as a side benefit of our proof, we provide a derivation, based entirely on the vector field method, of a Carleman-type estimate on the exterior of the ergoregion for a general class of stationary and asymptotically flat spacetimes.
description: 72 pages
Grille d'analyse des entrepôts de données : l'entrepôt répond-il à vos besoins et est-il conforme aux principes FAIR ?
Creators: name: Sébire, Fanny
Publisher: name: Zenodo
Year: 2023
Subjects: Entrepôt de données
Données de recherche
Partage de données
Principes FAIR

description: Cette grille d’analyse récapitule les questions qu’il est bon de se poser lorsque l’on a identifié un entrepôt de données intéressant. L’objectif pour le scientifique : vérifier si les caractéristiques et fonctionnalités de l’entrepôt répondent bien à ses besoins et si l’entrepôt permet de rendre ses données de recherche FAIR (Faciles à trouver, Accessibles, Interopérables et Réutilisables). La grille d’analyse propose des conseils sur la façon de trouver l’information dans deux répertoires d’entrepôts de données : re3data et FAIRsharing. Cette liste de critères a été élaborée en se basant sur les critères proposés par le Fonds national suisse.
Specific Differential Entropy Rate Estimation for Continuous-Valued Time Series
Creators: name: Darmon, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: Machine Learning (cs.LG)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We introduce a method for quantifying the inherent unpredictability of a continuous-valued time series via an extension of the differential Shannon entropy rate. Our extension, the specific entropy rate, quantifies the amount of predictive uncertainty associated with a specific state, rather than averaged over all states. We relate the specific entropy rate to popular `complexity' measures such as Approximate and Sample Entropies. We provide a data-driven approach for estimating the specific entropy rate of an observed time series. Finally, we consider three case studies of estimating specific entropy rate from synthetic and physiological data relevant to the analysis of heart rate variability.
Supplementary Figures from Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells
Creators: name: Singh, Anup Kumar
name: Khan, Soumen
name: Moore, Daniel
name: Andrews, Simon
name: Christophorou, Maria A.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Genomics

description: Supplementary Figures 1-9
Pre-potential in the $AdS_{5}\,\times\,S^{5}$ Type IIB superspace
Creators: name: Poláček, Martin
name: Siegel, Warren
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We found the pre-potential in the superspace with $AdS_{5}\,\times\,S^{5}$ background. The pre-potential appears as part of the vielbeins, without derivatives. The space-cone gauge destroys the bulk Lorentz covariance, but still preserves boundary Lorentz covariance (projective superspace) $SO\,(\,3,\,1\,)\,\otimes\,SO\,(\,4\,)$, i.e. symmetries of boundary CFT are manifest.
Peculiar Transverse Velocities of Galaxies from Quasar Microlensing. Tentative Estimate of the Peculiar Velocity Dispersion at $z\sim 0.5$
Creators: name: Mediavilla, E.
name: Jimenez-Vicente, J.
name: Munoz, J. A.
name: Battaner, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose to use the flux variability of lensed quasar images induced by gravitational microlensing to measure the transverse peculiar velocity of lens galaxies over a wide range of redshift. Microlensing variability is caused by the motions of the observer, the lens galaxy (including the motion of the stars within the galaxy), and the source; hence, its frequency is directly related to the galaxy's transverse peculiar velocity. The idea is to count time-event rates (e.g., peak or caustic crossing rates) in the observed microlensing light curves of lensed quasars that can be compared with model predictions for different values of the transverse peculiar velocity. To compensate for the large time-scale of microlensing variability we propose to count and model the number of events in an ensemble of gravitational lenses. We develop the methodology to achieve this goal and apply it to an ensemble of 17 lensed quasar systems. In spite of the shortcomings of the available data, we have obtained tentative estimates of the peculiar velocity dispersion of lens galaxies at $z\sim 0.5$, $σ_{\rm pec}(0.53\pm0.18)\simeq(638\pm213)\sqrt{\langle m \rangle/0.3 M_\odot} \, \rm km\, s^{-1}$. Scaling at zero redshift we derive, $σ_{\rm pec}(0)\simeq(491\pm164) \sqrt{\langle m \rangle/0.3 M_\odot} \, \rm km\, s^{-1}$, consistent with peculiar motions of nearby galaxies and with recent $N$-body nonlinear reconstructions of the Local Universe based on $Λ$CDM. We analyze the different sources of uncertainty of the method and find that for the present ensemble of 17 lensed systems the error is dominated by Poissonian noise, but that for larger ensembles the impact of the uncertainty on the average stellar mass may be significant.
On the photovoltaic effect asymmetry in ferroelectrics
Creators: name: Semak, S.
name: Kapustianyk, V.
name: Eliyashevskyy, Yu.
name: Bovgyra, O.
name: Kovalenko, M.
name: Mostovoi, U.
name: Doudin, B.
name: Kundys, B.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Despite symmetrical polarization, the magnitude of a light-induced voltage is known to be asymmetric with respect to poling sign in many photovoltaic (PV) ferroelectrics (FEs). This asymmetry remains unclear and is often attributed to extrinsic effects. We show here for the first time that such an asymmetry can be intrinsic, steaming from the superposition of asymmetries of internal FE bias and electro-piezo-strictive deformation. This hypothesis is confirmed by the observed decrease of PV asymmetry for smaller FE bias. Moreover, the both PV effect and remanent polarization are found to increase under vacuum-induced expansion and to decrease for gas-induced compression, with tens percents tunability. The change in cations positions under pressure is analysed through the first-principle density functional theory calculations. The reported properties provide key insight for FE-based solar elements optimization.
description: Journal paper, 8 pages, 4 figures
Modeling the population health impact of incorporating a multi-cancer early detection (MCED) test to existing cancer screening among immunocompromised individuals
Creators: name: Tan, Chia Jie
name: Ilham, Sabrina
name: Willis, Connor
name: Kim, Ashley
name: Cong, Ze
name: Brixner, Diana
name: Stenehjem, David
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: To assess the screening efficiency of an multi-cancer early detection (MCED) test added to standard of care (SoC) screening, compared to SoC screening alone, among immunocompromised individuals, and to estimate the diagnostic workup costs associated with positive screening results. We estimated the potential impact of cancer screening among immunocompromised individuals aged 50–79 years within the University of Utah Health system who underwent a stem cell/solid organ transplant or were diagnosed with a primary or secondary immunodeficiency disorder between January 2000 and February 2018. We derived cancer incidence rates from the Huntsman Cancer Institute Tumor Registry, and screening performance of SoC screening and an MCED test from published literature. Outcomes of screening efficiency included the true-positive to false-positive (TP:FP) ratio, diagnostic yield (DY), and cancer detection rate (CDR) for SoC screening alone and an incremental MCED test. Scenario and probabilistic sensitivity analyses were conducted. Among 4932 immunocompromised individuals aged 50–79 years, we estimated that 2595 tests would be done under SoC screening and assumed that all individuals received an additional MCED test. Adding an MCED test to SoC screening substantially improved screening efficiency (TP:FP = 1:1, DY = 5.15/1000 tests, CDR = 42.0%), compared to SoC screening alone (TP:FP = 1:99, DY = 1.23/1000 tests, CDR = 5.3%), assuming an MCED test with 100% uptake. Our findings were also robust to parameter uncertainty. Adding an MCED test to complement existing screening may be a highly efficient strategy to increase the detection of cancers among immunocompromised individuals. These results could help to improve cancer prevention and detection efforts among individuals with multiple cancer risk factors.
Comparative efficacy of ciltacabtagene autoleucel versus idecabtagene vicleucel in the treatment of patients with relapsed or refractory multiple myeloma previously treated with 2–4 prior lines of therapy: a matching-adjusted indirect comparison
Creators: name: Bar, Noffar
name: Diels, Joris
name: van Sanden, Suzy
name: Mendes, João
name: Hernando, Teresa
name: Burnett, Heather
name: Cost, Patricia
name: Schecter, Jordan M
name: Lendvai, Nikoletta
name: Patel, Nitin
name: Ishida, Tadao
name: Er, Jeremy
name: Harrison, Simon J
name: Lopez-Muñoz, Nieves
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: To estimate the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus idecabtagene vicleucel (ide-cel) in patients with relapsed/refractory multiple myeloma (RRMM) treated with 2–4 prior lines of therapy. Matching adjusted indirect comparison (MAICs) were performed using individual patient-level data (IPD) for cilta-cel from CARTITUDE-1 and CARTITUDE-4 and published aggregated data for ide-cel from KarMMa-3. Cilta-cel patients who met inclusion criteria from KarMMa-3 were selected, and outcomes were compared against data for ide-cel using simulated IPD derived from aggregate-level data from KarMMa-3. Patient characteristics were adjusted by reweighting cilta-cel IPD to match the distribution of prognostic factors in KarMMa-3. Comparative efficacy was estimated for response outcomes using a weighted logistic regression analysis and for progression-free survival using a weighted Cox proportional hazards model. Patients treated with cilta-cel were 1.2 times more likely to achieve overall response (relative response ratio [RR]: 1.18 [95% confidence interval: 1.03–1.34]; p = 0.04), 1.3 times more likely to achieve very good partial response or better (RR: 1.34 [1.15–1.57]; p = 0.003), and 1.9 times more likely to achieve complete response or better (RR: 1.91 [1.54–2.37]; p < 0.0001) versus ide-cel patients from KarMMa-3. Cilta-cel was associated with a significant 49% reduction in risk of disease progression or death versus ide-cel (hazard ratio: 0.51 [95% confidence interval: 0.31, 0.84]; p = 0.0078). For patients with triple-class exposed RRMM treated with 2–4 prior lines of treatment, cilta-cel was found to provide superior clinical benefit over ide-cel in terms of response and progression-free survival.
False periodicities in quasar time-domain surveys
Creators: name: Vaughan, S.
name: Uttley, P.
name: Markowitz, A. G.
name: Huppenkothen, D.
name: Middleton, M. J.
name: Alston, W. N.
name: Scargle, J. D.
name: Farr, W. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: There have recently been several reports of apparently periodic variations in the light curves of quasars, e.g. PG 1302-102 by Graham et al. (2015a). Any quasar showing periodic oscillations in brightness would be a strong candidate to be a close binary supermassive black hole and, in turn, a candidate for gravitational wave studies. However, normal quasars -- powered by accretion onto a single, supermassive black hole -- usually show stochastic variability over a wide range of timescales. It is therefore important to carefully assess the methods for identifying periodic candidates from among a population dominated by stochastic variability. Using a Bayesian analysis of the light curve of PG 1302-102, we find that a simple stochastic process is preferred over a sinusoidal variations. We then discuss some of the problems one encounters when searching for rare, strictly periodic signals among a large number of irregularly sampled, stochastic time series, and use simulations of quasar light curves to illustrate these points. From a few thousand simulations of steep spectrum (`red noise') stochastic processes, we find many simulations that display few-cycle periodicity like that seen in PG 1302-102. We emphasise the importance of calibrating the false positive rate when the number of targets in a search is very large.
description: 9 pages. 4 figures. Accepted for publication in MNRAS
Additional file 1 of Staff perspectives on the influence of patient characteristics on alarm management in the intensive care unit: a cross-sectional survey study
Creators: name: Balzer, Felix
name: Agha-Mir-Salim, Louis
name: Ziemert, Nicole
name: Schmieding, Malte
name: Mosch, Lina
name: Prendke, Mona
name: Wunderlich, Maximilian Markus
name: Memmert, Belinda
name: Spies, Claudia
name: Poncette, Akira-Sebastian
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy
classificationCode: 111714
subject: Mental Health

description: Supplementary Material 1
Defects as a factor limiting carrier mobility in WSe2: a spectroscopic investigation
Creators: name: Wu, Zhangting
name: Luo, Zhongzhong
name: Shen, Yuting
name: Zhao, Weiwei
name: Wang, Wenhui
name: Nan, Haiyan
name: Guo, Xitao
name: Sun, Litao
name: Wang, Xinran
name: You, Yumeng
name: Ni, Zhenhua
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The electrical performance of two dimensional transitional metal dichalcogenides (TMDs) is strongly influenced by the amount of structural defects inside. In this work, we provide an optical spectroscopic characterization approach to correlate the amount of structural defects and the electrical performance of WSe2 devices. Low temperature photoluminescence (PL) spectra of electron beam lithography (EBL) processed WSe2 presents a clear defect-induced PL emission due to excitons bound to defects, which would strongly degrade the electrical performance. By adopting an e-beam-free transfer-electrode technique, we are able to prepare backgated WSe2 device with limited amount of defects. A maximum hole-mobility of about 200 cm2/Vs was achieved due to reduced scattering sources, which is the highest reported value among its type. This work would not only provide a versatile and nondestructive method to monitor the defects in TMDs, but also a new route to approach the room temperature phonon-limited mobility in high performance TMDs devices.
description: 22 pages, 10 figures, to appear in Nano Research
A Hybrid Blockchain-Edge Architecture for Electronic Health Records Management with Attribute-based Cryptographic Mechanisms
Creators: name: Guo, Hao
name: Li, Wanxin
name: Nejad, Mark
name: Shen, Chien-Chung
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: This paper presents a hybrid blockchain-edge architecture for managing Electronic Health Records (EHRs) with attribute-based cryptographic mechanisms. The architecture introduces a novel attribute-based signature aggregation (ABSA) scheme and multi-authority attribute-based encryption (MA-ABE) integrated with Paillier homomorphic encryption (HE) to protect patients' anonymity and safeguard their EHRs. All the EHR activities and access control events are recorded permanently as blockchain transactions. We develop the ABSA module on Hyperledger Ursa cryptography library, MA-ABE module on OpenABE toolset, and blockchain network on Hyperledger Fabric. We measure the execution time of ABSA's signing and verification functions, MA-ABE with different access policies and homomorphic encryption schemes, and compare the results with other existing blockchain-based EHR systems. We validate the access activities and authentication events recorded in blockchain transactions and evaluate the transaction throughput and latency using Hyperledger Caliper. The results show that the performance meets real-world scenarios' requirements while safeguarding EHR and is robust against unauthorized retrievals.
description: Accepted for publication in IEEE Transactions on Network and Service Management (TNSM)
Meteorological Data from Yellowstone Lake During the Summer of 2018
Creators: name: Koper, Keith
Publisher: name: Zenodo
Year: 2022
Subjects: Yellowstone Lake, microseisms, weather data

description: We conducted a multidisciplinary geophysical experiment to study the relationship between wind, waves, bathymetry, and microseisms in Yellowstone Lake—a small, isolated body of water in which wind-driven gravity waves excite low-amplitude seismic energy at periods ~1.0 s with a regular daily pattern. During June 25 – August 4, 2018, we deployed 40 short-period seismometers, four meteorological stations, and two wave gauges in and around Yellowstone Lake. These instruments were complemented by seven permanent seismometers on the lake perimeter, and a contemporaneous deployment of ten lake bottom seismometers (LBS) on the floor of the north-central portion of the lake. The meteorological data are archived here. There are six ASCII files: README - description of the fields in the meteorological data files y101.txt - data file for met station 01 yl02.txt - data file for met station 02 yl03.txt - data file for met station 03 yl04.txt - data file for met station 04 met.coords - locations of the four met stations