cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Constraints on Crustal Structure in the Vicinity of the Adriatic Indenter (European Alps) From Vp and Vp/Vs Local Earthquake Tomography
Creators: name: Jozi Najafabadi, Azam
name: Haberland, Christian
name: Le Breton, Eline
name: Handy, Mark R.
name: Verwater, Vincent F.
name: Heit, Benjamin
name: Weber, Michael
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: European Alps
subject: crustal structure
subject: subduction
subject: seismic tomography
subject: body waves
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: In this study, 3-D models of P-wave velocity (Vp) and P-wave and S-wave ratio (Vp/Vs) of the crust and upper mantle in the Eastern and eastern Southern Alps (northern Italy and southern Austria) were calculated using local earthquake tomography (LET). The data set includes high-quality arrival times from well-constrained hypocenters observed by the dense, temporary seismic networks of the AlpArray AASN and SWATH-D. The resolution of the LET was checked by synthetic tests and analysis of the model resolution matrix. The small inter-station spacing (average of ∼15 km within the SWATH-D network) allowed us to image crustal structure at unprecedented resolution across a key part of the Alps. The derived P velocity model revealed a highly heterogeneous crustal structure in the target area. One of the main findings is that the lower crust is thickened, forming a bulge at 30–50 km depth just south of and beneath the Periadriatic Fault and the Tauern Window. This indicates that the lower crust decoupled both from its mantle substratum as well as from its upper crust. The Moho, taken to be the iso-velocity contour of Vp = 7.25 km/s, agrees with the Moho depth from previous studies in the European and Adriatic forelands. It is shallower on the Adriatic side than on the European side. This is interpreted to indicate that the European Plate is subducted beneath the Adriatic Plate in the Eastern and eastern Southern Alps.
The Social Construction of Global Health Priorities: An Empirical Analysis of Contagion in Bilateral Health Aid
Creators: name: Baccini, Leonardo
name: Heinzel, Mirko
name: Koenig-Archibugi, Mathias
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Bilateral Health Aid
subject: Contagion
subject: Global Health Priorities
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::320 Politikwissenschaft

description: Donors of development assistance for health typically provide funding for a range of disease focus areas, such as maternal health and child health, malaria, HIV/AIDS, and other infectious diseases. But funding for each disease category does not match closely its contribution to the disability and loss of life it causes and the cost-effectiveness of interventions. We argue that peer influences in the social construction of global health priorities contribute to explaining this misalignment. Aid policy-makers are embedded in a social environment encompassing other donors, health experts, advocacy groups, and international officials. This social environment influences the conceptual and normative frameworks of decision-makers, which in turn affect their funding priorities. Aid policy-makers are especially likely to emulate decisions on funding priorities taken by peers with whom they are most closely involved in the context of expert and advocacy networks. We draw on novel data on donor connectivity through health IGOs and health INGOs and assess the argument by applying spatial regression models to health aid disbursed globally between 1990 and 2017. The analysis provides strong empirical support for our argument that the involvement in overlapping expert and advocacy networks shapes funding priorities regarding disease categories and recipient countries in health aid.
Unravelling the Stability of Nightingale Song Over Time and Space Using Open, Citizen Science and Shared Data
Creators: name: Jäckel, Denise
name: Mortega, Kim G.
name: Brockmeyer, Ulrich
name: Lehmann, Gerlind U. C.
name: Voigt-Heucke, Silke L.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: birdsong
subject: cultural evolution
subject: geographic variation
subject: Luscinia megarhynchos
subject: repository
subject: song dialects
subject: vocal learning
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Open science approaches enable and facilitate the investigation of many scientific questions in bioacoustics, such as studies on the temporal and spatial evolution of song, as in vocal dialects. In contrast to previous dialect studies, which mostly focused on songbird species with a small repertoire, here we studied the common nightingale (Luscinia megarhynchos), a bird species with a complex and large repertoire. To study dialects on the population level in this species, we used recordings from four datasets: an open museum archive, a citizen science platform, a citizen science project, and shared recordings from academic researchers. We conducted the to date largest temporal and geographic dialect study of birdsong including recordings from 1930 to 2019 and from 13 European countries, with a geographical coverage of 2,652 km of linear distance. To examine temporal stability and spatial dialects, a catalog of 1,868 song types of common nightingales was created. Instead of dialects, we found a high degree of stability over time and space in both, the sub-categories of song and in the occurrence of song types. For example, the second most common song type in our datasets occurred over nine decades and across Europe. In our case study, open and citizen science data proved to be equivalent, and in some cases even better, than data shared by an academic research group. Based on our results, we conclude that the combination of diverse and open datasets was particularly useful to study the evolution of song in a bird species with a large repertoire.
A Large-Scale Evaluation Of Shape-Aware Neighborhood Weights And Neighborhood Sizes
Creators: name: Skrodzki, Martin
name: Zimmermann, Eric
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Point set
subject: Neighborhoods
subject: Features
subject: Classification
subject: Sigmoid
subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::004 Datenverarbeitung; Informatik

description: In this paper, we define and evaluate a weighting scheme for neighborhoods in point sets. Our weighting takes the shape of the geometry, i.e., the normal information, into account. This causes the obtained neighborhoods to be more reliable in the sense that connectivity also depends on the orientation of the point set. We utilize a sigmoid to define the weights based on the normal variation. For an evaluation of the weighting scheme, we turn to a Shannon entropy model for feature classification that can be proven to be non-degenerate for our family of weights. Based on this model, we evaluate our weighting terms on a large scale of both clean and real-world models. This evaluation provides results regarding the choice of optimal parameters within our weighting scheme. Furthermore, the large-scale evaluation also reveals that neighborhood sizes should not be fixed globally when processing models. Finally, we highlight the applicability of our weighting scheme within the application context of denoising.
MyGene2 automated match report: WDR37
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for WDR37.
A framework to assess the value of subgroup analyses when the overall treatment effect is significant
Creators: name: Sun, Hong
name: Vach, Werner
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Although subgroup analysis has been developed and widely used for many years, it is still not clear whether we should perform and how to perform such subgroup analyses when the overall treatment effect is significant. In this paper, we develop a framework to assess and compute the long-term impact of different strategies to perform subgroup analysis. We propose two performance measures: the average gain for patients in the future (E) and the probability of recommending a change to a worse treatment at individual patient level (P). Five families of decision rules are applied under different assumptions for the individual treatment effect (TE) variation. Three distributions reflecting optimistic, moderate, and pessimistic scenarios are assumed for true treatment effects across studies. This framework allows us to compare subgroup analyses decision rules, and we demonstrate through simulation studies that there are decision rules for subgroup analysis which can decrease P and increase E simultaneously compared to the situation of no subgroup analysis. These rules are much more liberal than the usual superiority testing. The latter typically implies a dramatic decrease in E.
title: Материалы научной конференции с международным участием "Неделя науки СПбПУ", 18–23 ноября 2019 года. Институт прикладной математики и механики
Creators: name: Научная конференция с международным участием "Неделя науки СПбПУ" (2019; Санкт-Петербург)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019

description: В сборник включены статьи студентов, аспирантов, молодых ученых и сотрудников СПбПУ, университетов, научных организаций и предприятий Санкт-Петербурга, России, зарубежных стран по материалам докладов, принятых на секционные заседания конференции «Неделя науки СПбПУ» Института прикладной математики и механики. Статьи отражают современный уровень научно-исследовательской работы участников конференции в области прикладной математики и механики. Представляют интерес для специалистов в различных областях знаний, учащихся и работников системы высшего образования и Российской академии наук.
A Framework to Assess the Value of Subgroup Analyses When the Overall Treatment Effect is Significant
Creators: name: Sun, Hong
name: Vach, Werner
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences

description: Although subgroup analysis has been developed and widely used for many years, it is still not clear whether we should perform and how to perform such subgroup analyses when the overall treatment effect is significant. In this paper, we develop a framework to assess and compute the long term impact of different strategies to perform subgroup analysis. We propose two performance measures: the average gain for patients in the future (E) and the probability of recommending a change to a worse treatment at individual patient level (P). Five families of decision rules are applied under different assumptions for the individual TE variation. Three distributions reflecting optimistic, moderate and pessimistic scenarios are assumed for true treatment effects accross studies. This framework allows us to compare subgroup analyses decision rules, and we demonstrate through simulation studies that there are decision rules for subgroup analysis which can decrease P and increase E simultaneously compared to the situation of no subgroup analysis. These rules are much more liberal than the usual superiority testing. The latter typically implies a dramatic decrease in E.
Relativistic meson spectra on ion-trap quantum simulators
Creators: name: Knaute, Johannes
name: Hauke, Philipp
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Bound states
subject: Cooling & trapping
subject: Quantum field theory
subject: Quantum information with trapped ions
subject: Quantum simulation
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: The recent rapid experimental advancement in the engineering of quantum many-body systems opens the avenue to controlled studies of fundamental physics problems via digital or analog quantum simulations. Here, we systematically analyze the capability of analog ion traps to explore relativistic meson spectra on current devices. We focus on the E8 quantum field theory regime, which arises due to longitudinal perturbations at the critical point of the transverse-field Ising model. As we show through exact numerics, for sufficiently strong long-range suppression in experimentally accessible spin chain models, absorption spectroscopy allows for the identification of the low-lying meson excitations with a good degree of accuracy even for small system sizes. Our proposal thus opens a way for probing salient features of quantum many-body systems reminiscent of meson properties in high-energy physics.
Orthopyroxene rim growth during reaction of (Co, Ni, Mn, Zn)-doped forsterite and quartz: Experimental constraints on element distribution and grain boundary diffusion
Creators: name: Incel, Sarah
name: Milke, Ralf
name: Wunder, Bernd
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Mantle metasomatism
subject: Orthopyroxene rim growth
subject: Doped forsterite samples
subject: Piston-cylinder experiments
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Mantle metasomatism is an important process in subduction zones in which fluids from the dehydrating oceanic slab interact with the overlying upper mantle resulting in a chemical alteration of the mantle. Consequently, this fluid-rock interaction may influence the mantle rock's physical properties such as the deformation behavior. In order to study element redistribution during mantle metasomatism in the laboratory, we used the simplified model reaction olivine + quartz = orthopyroxene, where olivine acts as representative for the upper mantle and quartz as proxy for the metasomatizing agent. We conducted piston-cylinder experiments at 1.5 GPa and 950 to 1400 °C, lasting between 48 and 288 h, on samples containing a mixture of quartz and one set of synthesized forsterite samples doped with either Co, Ni, Mn, or Zn. Additionally, we tested the influence of either nominally anhydrous or hydrous experimental conditions on the chemical distribution of the respective dopant element by using either crushable alumina or natural CaF2 as pressure medium. Results of the chemical analyses of the recovered samples show dopant specific partitioning between doped forsterite and orthopyroxene independent of the confining pressure medium; except for the runs in which Ni-doped forsterite samples were used. The observed Ni- and Co-enrichment in forsterite samples may be used to identify mantle rocks that underwent mantle metasomatism in nature.
Il rispetto delle regole del cibo in una società multiculturale
Creators: name: Ventrella, Carmela
Publisher: name: Euro-Balkan Law and Economics Review
Year: 2020
Subjects: Libertà religiosa; Multiculturalismo; Immigrazione; Vitto religioso- Mediazione; Religious freedom; Multiculturalism; Immigration; Religious food; Mediation

description: Nelle società multiculturali il rispetto delle prescrizioni alimentari dettate dai diversi credi favorisce la ridefinizione delle identità in un processo verso l’affermazione dei diritti dell’uomo. Un ruolo fondamentale è assunto dalle religioni quali fondamentali attori sociali nel ricercare, insieme con i governi, gli strumenti più idonei a garantire l’armoniosa convivenza dei popoli. Le riforme, introdotte nel nostro ordinamento, evidenziano la direzione di apertura, sia pur timida, verso le nuove istanze legate all’esercizio del diritto di libertà religiosa. In particolare, il “diritto a un’alimentazione sana”, in un significativa inclusione del dato religioso, si realizza attraverso tecniche indirette di tutela con precipuo riferimento all’esercizio delle prerogative legate all’appartenenza religiosa. Importante è la mediazione interculturale. In multicultural societies the compliance with food prescriptions, dictated by the different beliefs, helps to redefine identities in a process towards the affirmation of human rights. A considerable role is assumed by religions as fundamental social actors in seeking, together with governments, the most suitable instruments to guarantee the harmonious coexistence of peoples. Reforms, introduced in our legal system, highlight the direction of openness, albeit timid, towards the new instances linked to the exercise of the right of religious freedom. In particular, the “right to a healthy diet”, in a significant inclusion of religious data, is achieved through indirect techniques of protection with particular reference to the exercise of the prerogatives linked to religious affiliation. Intercultural mediation is important.
description: Euro-Balkan Law and Economics Review, N. 1 (2020): Fascicolo 1
D-JRP7-3.6 Collection of data on survival of Listeria monocytogenes in soil microcosms (Listadapt)
Creators: name: Listadapt
Publisher: name: Zenodo
Year: 2020

description: D-JRP7-3.6 Collection of data on survival of Listeria monocytogenes in soil microcosms Listadapt deliveable OHEJP Project
Planets or asteroids? A geochemical method to constrain the masses of White Dwarf pollutants
Creators: name: Buchan, Andrew M.
name: Bonsor, Amy
name: Shorttle, Oliver
name: Wade, Jon
name: Harrison, John
name: Noack, Lena
name: Koester, Detlev
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: planets and satellites: composition
subject: planets and satellites: general
subject: planets and satellites: interiors
subject: planets and satellites: physical evolution
subject: circumstellar matter
subject: white dwarfs
subject: 500 Naturwissenschaften und Mathematik::520 Astronomie::520 Astronomie und zugeordnete Wissenschaften

description: Polluted white dwarfs that have accreted planetary material provide a unique opportunity to probe the geology of exoplanetary systems. However, the nature of the bodies that pollute white dwarfs is not well understood: are they small asteroids, minor planets, or even terrestrial planets? We present a novel method to infer pollutant masses from detections of Ni, Cr, and Si. During core–mantle differentiation, these elements exhibit variable preference for metal and silicate at different pressures (i.e. object masses), affecting their abundances in the core and mantle. We model core–mantle differentiation self-consistently using data from metal–silicate partitioning experiments. We place statistical constraints on the differentiation pressures, and hence masses, of bodies which pollute white dwarfs by incorporating this calculation into a Bayesian framework. We show that Ni observations are best suited to constraining pressure when pollution is mantle-like, while Cr and Si are better for core-like pollution. We find three systems (WD0449-259, WD1350-162, and WD2105-820) whose abundances are best explained by the accretion of fragments of small parent bodies (<0.2 M⊕). For two systems (GD61 and WD0446-255), the best model suggests the accretion of fragments of Earth-sized bodies, although the observed abundances remain consistent (<3σ) with the accretion of undifferentiated material. This suggests that polluted white dwarfs potentially accrete planetary bodies of a range of masses. However, our results are subject to inevitable degeneracies and limitations given current data. To constrain pressure more confidently, we require serendipitous observation of (nearly) pure core and/or mantle material.
MyGene2 automated match report: ATP1A2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for ATP1A2.
Transition-Metal-Doping of CaO as Catalyst for the OCM Reaction, a Reality Check
Creators: name: Thum, Lukas
name: Riedel, Wiebke
name: Milojevic, Natasa
name: Guan, Chengyue
name: Trunschke, Annette
name: Dinse, Klaus-Peter
name: Risse, Thomas
name: Schomäcker, Reinhard
name: Schlögl, Robert
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: oxidative coupling of methane
subject: calcium oxide
subject: doping
subject: EPR
subject: transition metal doping
subject: heterogeneous catalysis
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: In this study, first-row transition metal-doped calcium oxide materials (Mn, Ni, Cr, Co., and Zn) were synthesized, characterized, and tested for the OCM reaction. Doped carbonate precursors were prepared by a co-precipitation method. The synthesis parameters were optimized to yield materials with a pure calcite phase, which was verified by XRD. EPR measurements on the doped CaO materials indicate a successful substitution of Ca2+ with transition metal ions in the CaO lattice. The materials were tested for their performance in the OCM reaction, where a beneficial effect towards selectivity and activity effect could be observed for Mn, Ni, and Zn-doped samples, where the selectivity of Co- and Cr-doped CaO was strongly reduced. The optimum doping concentration could be identified in the range of 0.04-0.10 atom%, showing the strongest decrease in the apparent activation energy, as well as the maximum increase in selectivity.
Inaccurate Confessions Pilot Testing
Creators: name: Crozier, William
name: Strange, Deryn
name: Rico, Gabriela
Publisher: name: OSF Registries
Year: 2018

description: Pilot testing materials and results.

In order to develop our case materials for use in the primary study, we want to ensure the materials are sufficiently memorable and provide usable guilt ratings. For piloting purposes, participants will complete an abbreviated procedure: first they will read one of two possible Opening Statements (containing the defendant's confession; Version A or Version B with different sets of evidence for counterbalancing purposes). Then, they will read the Direct Examination of an officer that contains all of the case facts. Participants will read one of four possible Directs: participants who read Opening A will receive either Direct A Strong (in which the evidence against the defendant is very strong; see attached Materials) or Direct B Weak (which contains evidence weakly implicating the defendant in the crime); participants who read Opening B will read Direct B Strong or Direct B Weak. Then, participants will complete guilt measures (including a Dichotomous guilty/not guilty, and a 1-100 probability of commission scale, 1=completely innocent, 100=completely guilty, 50=unsure) and a two-option forced choice memory test for the four pieces of evidence we are manipulating in the main study.

We will consider the materials appropriate for the primary study when we find:
1. Sufficient memorability for the four pieces of evidence, as defined by 75% or higher correct identification on the forced-choice memory test;
2. The "Strong" evidence case produces higher dichotomous "guilty" ratings than the "weak" evidence case; and
3. The materials avoid a floor effect for guilt ratings (neither the strong nor the weak case produces lower than a 20% conviction rate on dichotomous guilt measure).

We will recruit 80 participants (20 per A/B and strong/weak cell) from Amazon mTurk for this pilot study.

Participants will be excluded from the analyses if they:
1. Fail an instructional manipulation check; and
2. Fail to follow attentional instructions, specifically: stopping throughout the study, engaging in another task during the study, using a browser "back" button during the study, taking notes during the study, receiving help or talking to another person during the study.
3. Technical issues (as reported in a free response prompt).

Update: 10/1. Due to an error in Qualtrics survey flow, first round of data was not correctly collected. New materials / qsf has been uploaded, along with Pilot Data that shows conviction rates and memorability that conform to our pre-registered goals.
Individual Pianistic and Artistic Expression in Three Piano Compositions (1822-1962)
Creators: Kyurkchieva, Yoana Ivanova
Publisher: name: University of Alberta Library
Year: 2015

The full thesis for this degree consists of an audio recording, a public recital, and notes to accompany the recorded and live performance. The recording includes the following works: Johann Sebastian Bach, Largo from the Trio Sonata No. 5 in C Major, BWV 529, arranged for piano by Samuel Feinberg; Ludwig van Beethoven, Piano Sonata No. 32 in C Minor, Op. 111; and Robert Schumann, Carnaval, Op. 9. The notes explore the literature on these works and describe the distinctive pianistic and expressive elements of each from the perspective of the performer.
Root electrotropism in Arabidopsis does not depend on auxin distribution but requires cytokinin biosynthesis
Creators: name: Salvalaio, Maddalena
name: Oliver, Nicholas
name: Tiknaz, Deniz
name: Schwarze, Maximillian
name: Kral, Nicolas
name: Kim, Soo-Jeong
name: Sena, Giovanni
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Arabidopsis
subject: root electrotropism
subject: signal integration
subject: 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::580 Pflanzen (Botanik)

description: Efficient foraging by plant roots relies on the ability to sense multiple physical and chemical cues in soil and to reorient growth accordingly (tropism). Root tropisms range from sensing gravity (gravitropism), light (phototropism), water (hydrotropism), touch (thigmotropism), and more. Electrotropism, also known as galvanotropism, is the phenomenon of aligning growth with external electric fields and currents. Although root electrotropism has been observed in a few species since the end of the 19th century, its molecular and physical mechanisms remain elusive, limiting its comparison with the more well-defined sensing pathways in plants. Here, we provide a quantitative and molecular characterization of root electrotropism in the model system Arabidopsis (Arabidopsis thaliana), showing that it does not depend on an asymmetric distribution of the plant hormone auxin, but instead requires the biosynthesis of a second hormone, cytokinin. We also show that the dose–response kinetics of the early steps of root electrotropism follows a power law analogous to the one observed in some physiological reactions in animals. Future studies involving more extensive molecular and quantitative characterization of root electrotropism would represent a step toward a better understanding of signal integration in plants and would also serve as an independent outgroup for comparative analysis of electroreception in animals and fungi.
DNA binding, photocleavage behavior, and topoisomerase I inhibitory activity of Ru(II) complexes incorporating an asymmetric phenazine-type ligand
Creators: name: Liu, Xue-wen
name: Shu, Jun-Shi
name: Xiao, Yang
name: Shen, You-Ming
name: Zhang, Song-Bai
name: Lu, Ji-Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Pharmacology
Molecular Biology
Cell Biology
Engineering
Biochemistry
Biophysics

description: Two ruthenium complexes incorporating an asymmetric ligand, [Ru(L)2pipz]2+ (L = bpy (2,2′-bipyridine), phen (1,10-phenanthroline), pipz = 2-pyridine-1H-imidazo[4,5-b]phenazine), have been synthesized and characterized. The interactions of the two complexes with DNA have been investigated by UV–visible spectroscopy, fluorescence spectroscopy, and viscosity measurements. Both complexes bind to DNA by intercalation and efficiently cleave pBR322 DNA under irradiation. Singlet oxygen () was the main reactive oxygen species involved in DNA photocleavage. Topoisomerase inhibition and DNA strand passage assay demonstrated that both complexes can act as efficient catalytic inhibitors of DNA topoisomerase I.
DNA Binding, photocleavage behavior and topoisomerase I inhibitory activity of Ru(II) complexes incorporating an asymmetric phenazine-type ligand
Creators: name: Liu, Xue-wen
name: Shu, Jun-Shi
name: Xiao, Yang
name: Shen, You-Ming
name: Zhang, Song-Bai
name: Lu, Ji-Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Pharmacology
Molecular Biology
Cell Biology
Engineering
Biochemistry
Biophysics

description: Two ruthenium complexes incorporating an asymmetric ligand, [Ru(L)2pipz]2+ (L = bpy (2,2’-bipyridine), phen (1,10-phenanthroline), pipz = 2-pyridine-1H-imidazo[4,5-b]phenazine), have been synthesized and characterized. The interactions of the two complexes with DNA have been investigated by UV–visible spectroscopy, fluorescence spectroscopy and viscosity measurements. Both complexes bind to DNA by intercalation and efficiently cleave pBR322 DNA under irradiation. Singlet oxygen (1O2) was the main reactive oxygen species involved in DNA photocleavage. Topoisomerase inhibition and DNA strand passage assay demonstrated that both complexes can act as efficient catalytic inhibitors of DNA topoisomerase I.
The Formation of Highly Positive δ34S Values in Late Devonian Mudstones: Microscale Analysis of Pyrite (δ34S) and Barite (δ34S, δ18O) in the Canol Formation (Selwyn Basin, Canada)
Creators: name: Grema, Haruna M.
name: Magnall, Joseph M.
name: Whitehouse, Martin J.
name: Gleeson, Sarah A.
name: Schulz, Hans-Martin
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: sulfur isotopes
subject: microscale SIMS analyses
subject: anaerobic oxidation of methane
subject: microbial sulfate reduction
subject: sulfur cycling
subject: Late Devonian
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: The sulfur isotope composition of pyrite in marine sedimentary rocks is often difficult to interpret due to a lack of precise isotopic constraints for coeval sulfate. This study examines pyrite and barite in the Late Devonian Canol Formation (Selwyn Basin, Canada), which provides an archive of δ34S and δ18O values during diagenesis. Scanning electron microscopy (SEM) has been combined with microscale secondary ion mass spectrometry (SIMS) analysis (n = 1,032) of pyrite (δ34S) and barite (δ34S and δ18O) on samples collected from nine stratigraphic sections of the Canol Formation. Two paragenetic stages of pyrite and barite formation have been distinguished, both replaced by barium carbonate and feldspar. The δ34Sbarite and δ18Obarite values from all sections overlap, between +37.1‰ and +67.9‰ (median = +45.7‰) and +8.8‰ and +23.9‰ (median = +20.0‰), respectively. Barite morphologies and isotopic values are consistent with precipitation from diagenetically modified porewater sulfate (sulfate resupply << sulfate depletion) during early diagenesis. The two pyrite generations (Py-1 and Py-2) preserve distinct textures and end-member isotopic records. There is a large offset from coeval Late Devonian seawater sulfate in the δ34Spyrite values of framboidal pyrite (-29.4‰ to -9.3‰), consistent with dissimilatory microbial sulfate reduction (MSR) during early diagenesis. The Py-2 is in textural equilibrium with barite generation 2 (Brt-2) and records a broad range of more positive δ34SPy-2 values (+9.4‰ to + 44.5‰). The distinctive highly positive δ34Spyrite values developed from sulfate limited conditions around the sulfate methane transition zone (SMTZ). We propose that a combination of factors, including low sulfate concentrations, MSR, and sulfate reduction coupled to anaerobic oxidation of methane (SR-AOM), led to the formation of highly positive δ34Spyrite and δ34Sbarite values in the Canol Formation. The presence of highly positive δ34Spyrite values in other Late Devonian sedimentary units indicate that diagenetic pyrite formation at the SMTZ may be a more general feature of other Lower Paleozoic basins.
Constitutional Theories of International Organisations: Beyond the West
Creators: name: Peters, Anne
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: constitutional theories
subject: international organisations
subject: world order
subject: 300 Sozialwissenschaften::340 Recht::340 Recht

description: The Joint Statement by the Foreign Ministers of China and Russia on Certain Aspects of Global Governance in Modern Conditions of 23 March 2021 calls for “the establishment of a fairer, more democratic and rational multipolar world order.” The paper inquires how constitutional theories of international organisations have in the past and present sought to contribute to world order. It identifies three waves of such theory since the 1960s. Looking in more detail at the ongoing third wave, it identifies and seeks to pull out further a constitutional model which upscales the proto-democratic practices in international organisations by strengthening forums for participation and contestation, which rectifies to the north-south imbalance inter alia rooted in the colonial heritage by involving more actors from the global south, and which tackles the global social question upfront.
title: Effects of verbal instructions and physical threat removal prior to extinction training on the return of conditioned fear
Creators: name: Wendt, Julia
name: Hufenbach, Miriam C.
name: König, Jörg
name: Hamm, Alfons O.
Publisher: name: Universität Potsdam
Year: 2020

description: Instructions given prior to extinction training facilitate the extinction of conditioned skin conductance (SCRs) and fear-potentiated startle responses (FPSs) and serve as laboratory models for cognitive interventions implemented in exposure-based treatments of pathological anxiety. Here, we investigated how instructions given prior to extinction training, with or without the additional removal of the electrode used to deliver the unconditioned stimulus (US), affect the return of fear assessed 24 hours later. We replicated previous instruction effects on extinction and added that the additional removal of the US electrode slightly enhanced facilitating effects on the extinction of conditioned FPSs. In contrast, extinction instructions hardly affected the return of conditioned fear responses. These findings suggest that instruction effects observed during extinction training do not extent to tests of return of fear 24 hours later which serve as laboratory models of relapse and improvement stability of exposure-based treatments.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 599
title: Contrast and Assimilation Effects on Self-Evaluation of Performance and Task Interest in a Sample of Elementary School Children
Creators: name: Bosch, Jannis
name: Wilbert, Jürgen
Publisher: name: Universität Potsdam
Year: 2020

description: Social comparison processes and the social position within a school class already play a major role in performance evaluation as early as in elementary school. The influence of contrast and assimilation effects on self-evaluation of performance as well as task interest has been widely researched in observational studies under the labels big-fish-little-pond and basking-in-reflected-glory effect. This study examined the influence of similar contrast and assimilation effects in an experimental paradigm. Fifth and sixth grade students (n = 230) completed a computer-based learning task during which they received social comparative feedback based on 2 × 2 experimentally manipulated feedback conditions: social position (high vs. low) and peer performance (high vs. low). Results show a more positive development of task interest and self-evaluation of performance in both the high social position and the high peer performance condition. When applied to the school setting, results of this study suggest that students who already perform well in comparison to their peer group are also the ones who profit most from social comparative feedback, given that they are the ones who usually receive the corresponding positive performance feedback.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 600
Custom Insert for Dysplastic Glenoid in Reverse Total Shoulder Arthroplasty
Creators: name: Samona .J
name: Owen .J
name: Martin, S.
Publisher: name: figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine

description: Arthritis is the leading cause of disability in the US workforce, leading to debilitating limitations with mobility and function in an otherwise healthy adult. In 2005, 21.6% of US adults (46.4 million) were formally diagnosed with arthritis, and by 2030 is projected to reach 40% (~67 million) [1-3]. A high correlation exists between age and the presence of rotator cuff disease and glenohumeral arthritis. The average age of individuals with unilateral cuff tears is 58.7, 67.8 years for those with bilateral, and 50% likelihood of a bilateral tear after age 60. It is estimated 13% of patients in their fifties suffer from a cuff tears and 54% of patients 60 years or older, with more than half of asymptomatic rotator cuff tears progressing in size and becoming symptomatic within 3 years [4- 6]. After the knee, the shoulder is the second most common site of chronic joint pain (63.4%vs. 30.6%) [7]. Shoulder arthroplasty accounted for 3%(vs. 96% for hip and knee) of all inpatient arthroplasty procedures performed in 2006. An increase of 2.5x (from 19,000 to 47,000) in the number of shoulder arthroplasties in the United States occurred between the years of 1998 to 2008, more than 2/3 performed on patients older than age 65 [8]. These numbers are significant because trends show between 2012 and 2050 the US will experience a considerable increase in the proportion of the elderly population. 39.6 million people 65 years or older were living in the US in 2009, representing 12.9% of the population or approximately one in every eight Americans
Prevalence of Low Vitamin D and Disability Among Egyptian Female Patients with Rheumatoid Arthritis
Creators: name: Abogamal AF
name: Yasein YA
name: AE, Mansour
name: Nassar .Y
name: Mahmoud .E
name: Abdalaziz AF
name: MS, Mustafa
Publisher: name: figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine

description: Background: Vitamin D deficiency was reported to be common in rheumatoid arthritis patients and an association with female sex, disease severity, higher disease activity and worse quality of life was suggested. Objectives: To estimate the prevalence of different levels of vitamin D and disability among female patients with rheumatoid arthritis, and to investigate its possible impact on the degree of disability in rheumatoid arthritis. Subjects & Methods: A cross sectional hospital-based survey conducted during the year 2015-2016. Total number of patients included in the study was 160, with a mean age of 44.80 ± 3.69 years. The data was collected through an interview questionnaire from all participants over a period of one month (November 2015). Results: The prevalence of low levels of vitamin D and disability among rheumatoid arthritis patients was 54.4% and 63.7% respectively. There was no statistically significant difference between different levels of vitamin D regarding age and duration of rheumatoid arthritis (P > 0.05). Class IV and III of disability was commonly reported among rheumatoid arthritis patients with a disease duration of more than 5 years and represented 27.3% and 24.5% respectively, and there was statistically significant difference (P < 0.05). There was a significant association between different classes of disability and different levels of vitamin D (χ2 = 15.28, P < 0.05). Conclusion: It appears that low vitamin D is highly prevalent in patients with rheumatoid arthritis and that vitamin D insufficiency and deficiency may be linked to disease impact on functional ability and disability
Ab initio study of ultrafast spin dynamics in Gdx(FeCo)1−x alloys
Creators: name: Dewhurst, J. K.
name: Shallcross, S.
name: Radu, Ionela
name: Elliott, P.
name: V. Korff Schmising, C.
name: Sharma, S.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: spin dynamics
subject: Fe–Gd alloys
subject: ab initio study
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Using an ultrashort laser pulse, we explore ab initio the spin dynamics of Gdx(FeCo)1−𝑥 at femtosecond time scales. Optical excitations are found to drive charges from Fe majority d-states to unoccupied Gd f-minority states with f-electron character excited occupation lagging behind that of the d-electron character, leading to substantial demagnetization of both species while leaving the global moment almost unchanged. For x > 0.33, this results in the creation of an ultrafast ferromagnetic (FM) transient by the end of the laser pulse with the Gd demagnetization rate slower than that of Fe. For all concentrations, the Gd moments begin to rotate from their ground state orientations developing in-plane moments of between 0.2 and 0.5 μB. Thus, the ultrafast spin dynamics of the material captures three important ingredients of all optical switching that occurs at much later (picosecond) times: (i) the development of a FM transient, (ii) the different rates of demagnetization of Fe and Gd, and (iii) the breaking of the collinear symmetry of the ground state. Furthermore, several predictions are made about the behavior of Fe–Gd alloys that can be experimentally tested and can lead to a spin-filtering device.
title: Общедоступные библиотеки Санкт-Петербурга. 10 лет вместе
title: Public libraries of St. Petersburg. 10 years together
Creators: name: Ахти, Елена
name: "Корпоративные библиотечные системы: технологии и инновации", международная научно-практическая конференция (18; 2019; Санкт-Петербург, Хельсинки)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019
Subjects: электронные ресурсы
портал
сетевое взаимодействие

description: В статье представлена деятельность Корпоративной сети общедоступных библиотек Санкт-Петербурга в течение 10 лет. Выявлены новые тенденции в организации работы библиотечной корпорации, анализируются направления деятельности библиотек, подходы к созданию ресурсов. Рассматривается деятельность ЦГПБ им. В. В. Маяковского как методического центра и головного сетевого центра для общедоступных библиотек Санкт-Петербурга.
description: The article presents the activities of the Corporate Network of Public Libraries of St. Petersburg for 10 years. New trends in the organization of the work of the library corporation have been identified, and the directions of library activities and approaches to resource creation are being analysed. The activity of TsGPB named after V. V. Mayakovsky as a methodological center and a head network center for public libraries of St. Petersburg is considered.
Higher-order Van Hove singularity in magic-angle twisted trilayer graphene
Creators: name: Guerci, Daniele
name: Simon, Pascal
name: Mora, Christophe
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Density of states
subject: Dirac fermions
subject: Electronic structure
subject: Fermi surface
subject: van Hove singularity
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Twisted trilayer graphene (TTG) has recently emerged experimentally as a fascinating playground to study correlated and exotic superconducting phases. We have found that TTG hosts a zero-energy higher-order Van Hove singularity with an exponent −1/3 that is stronger than the one predicted in twisted bilayer graphene. This singularity is protected by a threefold rotation symmetry and a combined mirror-particle-hole symmetry and can be tuned with only the twist angle and a perpendicular electric field. It arises from the combined merging of Van Hove singularities and Dirac cones at zero energy, a scheme that goes beyond the recent classifications of Van Hove singularities in single-band models. This structure gives a topological Lifshitz transition, with anomalous exponent −2/5, which can be achieved in TTG by varying a third control parameter such as the atomic corrugation. The interplay between the nonstandard class of higher-order Van Hove singularities and interaction effects offers an unprecedented platform for studying correlation and superconductivity.
Osteoporosis in Male Ankylosing Spondylitis Patients
Creators: name: Soliman .E
Publisher: name: figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine

description: Ankylosing Spondylitis (AS) is a chronic disease with inflammation at the enthesis of the spine and peripheral skeleton, which leads to bony erosion or juxtain sertional osteoporosis in the early stages. However, in later stages, new bone formation, syndesmophytes and ankylosis can occur. Generalized as well as regional osteopaenia is common in AS [1] with a frequency ranging from 50-92% [2-4]. It ranges from 41–62% in spine and 46–86% in femur
Endosome NOX2 oxidase promotes viral pathogenicity and provides a potential target for novel antiviral therapies
Creators: name: EUNICE ELIZABETH TO
Publisher: name: Monash University
Year: 2017
Subjects: Pharmacology

description: Viral infections pose an imminent global health threat, and with emerging anti-viral resistance and delays in vaccine development, there is an urgent need for novel therapeutic approaches to target host-cell interactions, irrespective of the infecting strain. This thesis has advanced our understanding of endosome biology and cell signalling of viruses, by identifying a fundamental mechanism of virus pathogenicity involving NOX2 and TLR7. We have identified a novel drug that inhibits endosomal ROS generation to alleviate influenza A virus pathology and potentially other globally devastating viruses.