cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design Curricula Study & Hands-On Distributed Design Studio
Creators: name: Covey, Preston K.
name: Ballay, Joe
Publisher: name: Carnegie Mellon University
Year: 1987
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: The following material constitutes an interim report by Joe Ballay on a summer project that I commissioned to begin to coordinate thinking on the design of design curricula for general or 'core' education. Included are an outline of the position paper to result from the project (on strategies for introducing design as a theme, skill set, and salient component of a liberal arts or core curriculum) and appendix material. Joe Ballay had approached me with a proposal to investigate and design software that would support hands-on design studio conditions on our distributed computer network. This proposal required a broader study.
Adiabatic dynamics of coupled spins and phonons in magnetic insulators
Creators: name: Ren, Shang
name: Bonini, John
name: Stengel, Massimiliano
name: Dreyer, Cyrus E.
name: Vanderbilt, David
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In conventional \textit{ab initio} methodologies, phonons are calculated by solving equations of motion involving static interatomic force constants and atomic masses. The Born-Oppenheimer approximation, where all electronic degrees of freedom are assumed to adiabatically follow the nuclear dynamics, is also adopted. This approach does not fully account for the effects of broken time-reversal symmetry in systems with magnetic order. Recent attempts to rectify this involve the inclusion of the velocity dependence of the interatomic forces in the equations of motion, which accounts for time-reversal symmetry breaking, and can result in chiral phonon modes with non-zero angular momentum even at the zone center. However, since the energy ranges of phonons and magnons typically overlap, the spins cannot be treated as adiabatically following the lattice degrees of freedom. Instead, phonon and spins must be treated on a similar footing. Focusing on zone-center modes, we propose a method involving Hessian matrices and Berry curvature tensors in terms of both phonon and spin degrees of freedom, and describe a first-principles methodology for calculating these. We then solve Lagrange's equations of motion to determine the energies and characters of the mixed excitations, allowing us to quantify, for example, the energy splittings between chiral pairs of phonons in some cases, and the degree of magnetically induced mixing between infrared and Raman modes in others. The approach is general, and can be applied to determine the adiabatic dynamics of any mixed set of slow variables.
description: Added a discussion section on the role of SOC and fixed some typos. This article has been accepted by Physical Review X
Stochastic Successive Convex Approximation for Non-Convex Constrained Stochastic Optimization
Creators: name: Liu, An
name: Lau, Vincent
name: Kananian, Borna
Publisher: name: arXiv
Year: 2018
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper proposes a constrained stochastic successive convex approximation (CSSCA) algorithm to find a stationary point for a general non-convex stochastic optimization problem, whose objective and constraint functions are non-convex and involve expectations over random states. Most existing methods for non-convex stochastic optimization, such as the stochastic (average) gradient and stochastic majorization-minimization, only consider minimizing a stochastic non-convex objective over a deterministic convex set. The proposed CSSCA algorithm can also handle stochastic non-convex constraints in optimization problems, and it opens the way to solving more challenging optimization problems that occur in many applications. The algorithm is based on solving a sequence of convex objective/feasibility optimization problems obtained by replacing the objective/constraint functions in the original problems with some convex surrogate functions. The CSSCA algorithm allows a wide class of surrogate functions and thus provides many freedoms to design good surrogate functions for specific applications. Moreover, it also facilitates parallel implementation for solving large scale stochastic optimization problems, which arise naturally in today's signal processing such as machine learning and big data analysis. We establish the convergence of CSSCA algorithm with a feasible initial point, and customize the algorithmic framework to solve several important application problems. Simulations show that the CSSCA algorithm can achieve superior performance over existing solutions.
description: submitted to IEEE Transactions on Signal Processing, under minor revision
Phase recovery from phaseless scattering data for discrete Schrödinger operators
Creators: name: Novikov, Roman
name: Sharma, Basant Lal
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mathematical Physics (math-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider scattering for the discrete Schrödinger operator on the square lattice $\mathbb{Z}^d$, $d \ge 1$, with compactly supported potential. We give formulas for finding the phased scattering amplitude from phaseless near-field scattering data.
description: Keywords: Discrete Schr\"{o}dinger operators, monochromatic scattering data, phase retrieval, phaseless inverse scattering
Nondestructive readout for a superconducting flux qubit
Creators: name: Lupascu, A.
name: Verwijs, C. J. M.
name: Schouten, R. N.
name: Harmans, C. J. P. M.
name: Mooij, J. E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a new readout method for a superconducting flux qubit, based on the measurement of the Josephson inductance of a superconducting quantum interference device that is inductively coupled to the qubit. The intrinsic flux detection efficiency and back-action are suitable for a fast and nondestructive determination of the quantum state of the qubit, as needed for readout of multiple qubits in a quantum computer. We performed spectroscopy of a flux qubit and we measured relaxation times of the order of 80 $μs$.
description: 4 pages, 4 figures; modified content, figures and references; accepted for publication in Phys. Rev. Lett
Lyman alpha Absorption Systems and the Intergalactic Medium
Creators: name: Efstathiou, George
name: Schaye, Joop
name: Theuns, Tom
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The last few years have seen a dramatic improvement in our understanding of the origin of Lyman alpha absorption systems. Hydrodynamic numerical simulations of cold dark matter dominated universes have shown that the many properties of the Lyman alpha absorption systems can be explained by a photoionized, space-filling, intergalactic medium. Lyman alpha lines offer promising probes of the photoionizing background, the amplitude of the mass fluctuations at high redshift and the evolution of the equation of state of the intergalactic medium.
description: 14 pages, 10 figures (2 gif). To appear in the Philosophical Transactions of The Royal Society, Series A. Corrected a verbal sign error
A dynamical model for pion electroproduction on the nucleon
Creators: name: Caia, George L.
name: Wright, Louis E.
name: Pascalutsa, Vladimir
Publisher: name: arXiv
Year: 2005
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We develop a Lorenz- and gauge-invariant dynamical model for pion electroproduction in the resonance region. The model is based on solving of the Salpeter (instantaneous) equation for the pion-nucleon interaction with a hadron-exchange potential. We find that the one-particle-exchange kernel of the Salpeter equation for pion electroproduction develops an unphysical singularity for a finite value of $Q^{2}$. We analyse two methods of dealing with this problem. Results of our model are compared with recent single-polarization data for pion electroproduction.
Demoralizing causation
Creators: name: Danks, David
name: Rose, David
name: Machery, Edouard
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: There have recently been a number of strong claims that normative considerations, broadly construed, influence many philosophically important folk concepts and perhaps are even a constitutive component of various cognitive processes. Many such claims have been made about the influence of such factors on our folk notion of causation. In this paper, we argue that the strong claims found in the recent literature on causal cognition are overstated, as they are based on one narrow type of data about a particular type of causal cognition; the extant data do not warrant any wide-ranging conclusions about the pervasiveness of normative considerations in causal cognition. Of course, almost all empirical investigations involve some manner of ampliative inference, and so we provide novel empirical results demonstrating that there are types of causal cognition that do not seem to be influenced by moral considerations.
Additional file 9 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships
Creators: name: Tang, Chenqian
name: Chen, Xin
name: Deng, Yunfei
name: Geng, Liyang
name: Ma, Jianhui
name: Wei, Xueyan
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Fig. S1 Phylogenetic tree base on trnR-atpA region resulting from the maximum likelihood (ML) analysis with Bootstrap value at nodes. Fig. S2 Phylogenetic tree base on petN-psbM region resulting from ML analysis with Bootstrap value at nodes. Fig. S3 Phylogenetic tree base on rpl32-trnL region resulting from ML analysis with Bootstrap value at nodes. Fig. S4 Phylogenetic tree base on trnT-trnL region resulting from ML analysis with Bootstrap value at nodes. Fig. S5 Phylogenetic tree base on trnH-psbA region resulting from ML analysis with Bootstrap value at nodes. Fig. S6 Phylogenetic tree base on ndhC-trnV region resulting from ML analysis with Bootstrap value at nodes. Fig. S7 phylogenetic tree base on 6 regions (ndhC-trnV + petN-psbM+ rpl32-trnL + trnH-psbA + trnT-atpA+ trnT-trnL) resulting from ML analysis with Bootstrap value at nodes.
Delineating classes of computational complexity via second order theories with weak set existence principles.
Creators: name: Ignjatovic╠î
Publisher: name: Carnegie Mellon University
Year: 1994
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: Abstract: "In this paper we characterize the well-known computational complexity classes of the polynomial time hierarchy as classes of provably recursive functions (with graphs of suitable bounded complexity) of some second order theories with weak comprehension axiom schemas but without any induction schemas (Theorem 6). We also find a natural relationship between our theories and the theories of bounded arithmetic S[superscript i]/ (Lemmas 4 and 5). Our proofs use a technique which enables us to 'speed up' induction without increasing the bounded complexity of the induction formulas. This technique is also used to obtain an interpretability result for the theories of bounded arithmetic S[superscript i]/ (Theorem 4)."
A quantum Monte Carlo algorithm for arbitrary spin-1/2 Hamiltonians
Creators: name: Barash, Lev
name: Babakhani, Arman
name: Hen, Itay
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a universal parameter-free quantum Monte Carlo (QMC) algorithm designed to simulate arbitrary spin-$1/2$ Hamiltonians. To ensure the convergence of the Markov chain to equilibrium for every conceivable case, we devise a clear and simple automated protocol that produces QMC updates that are provably ergodic and satisfy detailed balance. We demonstrate the applicability and versatility of our method by considering several illustrative examples, including the simulation of the XY model on a triangular lattice, the toric code, and random $k$-local Hamiltonians. We have made our program code freely accessible on GitHub.
description: 18 pages, 8 figures
Nonlinear Supersymmetry Without the GSO Projection and Unstable D9-Brane
Creators: name: Hara, Tabito
name: Yoneya, Tamiaki
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Orientable open string theories containing both bosons and fermions without the GSO projection are expected to have the 10 dimensional N=2(A) space-time supersymmetry in a spontaneously broken phase. We study the low-energy theorem for the nonlinearly realized N=2 supersymmetry using the effective action for an unstable D9-brane. It is explicitly confirmed that the 4-fermion open string amplitudes without the GSO projection obey the low-energy theorem derived from the nonlinear N=2 supersymmetry. An intimate connection between the existence of the hidden supersymmetry and the open-open string (s-t) duality is pointed out.
description: 18 pages, no figure, further typos are corrected
Lifting problem for universal quadratic forms over totally real cubic number fields
Creators: name: Kim, Daejun
name: Lee, Seok Hyeong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11E12, 11R16, 11H06, 11H55

description: Lifting problem for universal quadratic forms asks for totally real number fields $K$ that admit a positive definite quadratic form with coefficients in $\mathbb{Z}$ that is universal over the ring of integers of $K$. In this paper, we show that $K=\mathbb{Q}(ζ_7+ζ_7^{-1})$ is the only such totally real cubic field. Moreover, we show that there is no such biquadratic field.
description: 12 pages
ПРАВОВОЕ ТРИЕДИНСТВО КАК ФОРМА СУЩЕСТВОВАНИЯ КОНСТИТУЦИОННЫХ ПРИНЦИПОВ
Creators: name: МОСИН СЕРГЕЙ АНАТОЛЬЕВИЧ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: КОНСТИТУЦИОННЫЙ ПРИНЦИП
ФОРМА СУЩЕСТВОВАНИЯ КОНСТИТУЦИОННЫХ ПРИНЦИПОВ
КОНСТИТУЦИОННАЯ АКСИОМА-ПРИНЦИП
КОНСТИТУЦИОННАЯ ПРЕЗУМПЦИЯ-ПРИНЦИП
КОНСТИТУЦИОННАЯ ФИКЦИЯ-ПРИНЦИП
CONSTITUTIONAL PRINCIPLE
FORM OF EXISTENCE OF THE CONSTITUTIONAL PRINCIPLES
CONSTITUTIONAL AXIOM-PRINCIPLE
CONSTITUTIONAL PRESUMPTION-PRINCIPLE
AND CONSTITUTIONAL FICTION-PRINCIPLE

description: В статье рассматривается форма существования конституционных принципов как правовое триединство, в соответствии с которым конституционный принцип является единой в своей правовой сути категорией, как основополагающее положение, формирующее исходные правовые начала государственного устройства во всех его аспектах, но при этом имеет три конституционно-правовых проявления, воплощаясь в конституционной аксиоме принципе, конституционной презумпции-принципе и конституционной фикции-принципе.
title: Development of fatty acid mimetic fragments as agonist tools for lipid-sensing transcription factors
Creators: name: Stiller, Tanja
name: Merk, Daniel
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2025
Subjects: subject: 615
subject: 610

description: Fatty acid mimetics (FAMs) are bioactive molecules with attractive drug-like chemical features. They are acting through the binding sites of endogenous fatty acid metabolites on enzymes, transporters and receptors. Therefore, FAMs might offer new opportunities in ligand development for lipid-sensing transcription factors. Nuclear receptors (NRs) are a family of ligand-activated transcription factors that regulate several physiological processes. The three NR4A receptors Nur77, Nurr1 and NOR-1 holding promising therapeutic potential in neurodegenerative diseases. Binding of prostaglandin E1 and its dehydrated metabolite (PGA1) suggested that NR4A receptors interact with FAMs. The liver receptor homolog-1 (LRH-1) is an orphan member of the NR family with therapeutic potential in metabolic diseases and hepatic inflammation. Recent studies identified LRH-1 as a cellular phospholipid sensor. Designed polypharmacology has emerged as an innovative strategy for the development of small molecules that achieve an improved therapeutic effect by simultaneously influencing two or more target molecules. NRs THR, PPARγ and FXR are fatty acid and lipid-sensing transcription factors and regulate metabolic balance in different tissues. Moreover, PPARγ and FXR are heterodimer partner of RXR. Synergies may also be accessible by simultaneous activation of both heterodimer partners. To explore FAMs as putative NR-ligands we have established a custom focused library of 92 chemically diverse fragment-like FAMs and screened it for the modulation of THR, PPARγ, FXR, RXR and LRH-1, as well as the three NR4A receptors. The activity screening revealed NR agonism of several FAM fragments. We identified benzyloxy benzoic acid derivatives as potent NR4A modulators with nanomolar-potencies. New LRH-1 ligand chemotypes for further optimization have been developed and moreover, we established dual modulator fragments for THR/PPARγ which involve in transcriptional regulation of metabolic balance. Overall, our screening results and preliminary structure-activity-relationship studies offer great potential of FAMs to obtain potent modulators for lipid-sensing transcription factors.
Delineating classes of computational complexity via second order theories with weak set existence principles.
Creators: name: Ignjatovic╠î, Aleksandar
Publisher: name: Carnegie Mellon University
Year: 1991
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: Abstract: "In this paper we characterize the well-known computational complexity classes of the Polynomial Time Hierarchy as classes of provable functions of some second order theories with weak comprehension. Our formalism is somewhat different from Leivant's, who was the first to introduce such a theory for delineating polynomial time computable functions. Besides being, in our view, foundationally advantageous,our formalism also has significant technical advantages: it enables us to characterize all the classes of the Polynomial Time Hierarchy within our theories and also to relate these theories very naturally to Buss' theories of bounded arithmetic S[superscript i/].The latter feature enables us to bypass both a complicated cut-elimination procedure or a difficult model-theoretic argument usually used tocharacterize provable functions of a theory, and a tedious proof of representability of functions from various complexity classes in the theories we consider, reducing both problems to such theorems about bounded arithmetic."
The role of temperature and Coulomb correlation in stabilization of CsCl-phase in FeS under pressure
Creators: name: Shorikov, A. O.
name: Roizen, V. V.
name: Oganov, A. R.
name: Anisimov, V. I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The iron-sulfur system is important for planetary interiors and is intensely studied, particularly for better understanding of the cores of Mars and Earth. Yet, there is a paradox about high-pressure stability of FeS: ab initio global optimization (at DFT level) predicts a Pmmn phase (with a distorted rocksalt structure) to be stable at pressures above ~120 GPa, which has not yet been observed in the experiments that instead revealed a CsCl-type phase which, according to density functional calculations, should not be stable. Using quasiharmonic free energy calculations and the dynamical mean field theory, we show that this apparent discrepancy is removed by proper account of electron correlations and entropic effects.
description: 5 pages, 3 figures
title: Towards modulation of polymicrobial communities in chronic lung diseases through targeting the Carbon Storage regulator A (CsrA)
Creators: name: Mazlom, Kyana
name: Calvin-Brown, Marces
name: Zoller, Ben
name: Wu, Yingwen
name: Jakob, Valentin
name: Empting, Martin
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2025
Subjects: subject: 615
subject: 610

description: Multidrug resistance is an ongoing problem in infectious diseases; especially considering difficult-to-treat Gram-negative pathogens. Additional complexity is provided by the polymicrobial nature of our respiratory and gastro-intestinal systems involving the beneficial microbiome, but also associated polymicrobial infections. Acute and chronic diseases are caused by a variety of pathogenic Gram-negative microorganisms like e.g. Escherichia Coli, Pseudomonas Aeruginosa or Yersinia Pseudotuberculosis. Investigating new modalities to achieve anti-virulence effects in this polymicrobial scenario is of high interest. Our aim is to modulate microbial communities through addressing the post-translational regulator system called carbon storage regulator A (CsrA) in E. Coli and Y. Pseudotuberculosis. In P. aeruginosa, it is called repressor of secondary metabolites (RsmA). CsrA/RsmA is an astonishingly widespread bacterial RNA binding protein mediating global effects on translation by binding to GGA-motifs in mRNAs. We identified novel, easily accessible CsrA binding scaffolds through biophysical screening (Fluorescence Polarization competition assay) and a macrocyclic CsrA binding peptide via phage display technology. In order to find new binders, a commercial structurally diverse compound library was employed for a two-step screening procedure using pharmacophore-guided docking as an in silico prescreening filter and fluorescence polarization as a functional in vitro assay. By this means, we identified four new classes of CsrA binding scaffolds for medicinal chemistry optimization. However, only two classes were confirmed to be effective CsrA inhibitors via cell assays. We aim to assess cellular effects of optimized inhibitors in a bacterial test system using qRT-PCR gene expression and Luciferase reporter gene assay methodolgies in E. Coli. These assays are still in development and further optimizations are needed. We also included transport studies to evaluate the accumulation of the potential scaffolds in the cells.
Photoionization instability of the Fe K absorbing plasma in the neutron star transient AX J1745.6-2901
Creators: name: Bianchi, Stefano
name: Ponti, Gabriele
name: Muñoz-Darias, Teo
name: Petrucci, Pierre-Olivier
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: AX J1745.6-2901 is a Low Mass X-ray Binary with an accreting neutron star, showing clear evidence for highly ionized absorption. Strong ionized Fe K$α$ and K$β$ absorption lines are always observed during the soft state, whereas they disappear during the hard states. We computed photoionization stability curves for the hard and the soft state, under different assumptions on the adopted spectral energy distributions and the physical parameters of the plasma. We observe that the ionized absorber lies always on a stable branch of the photoionization stability curve during the soft state, while it becomes unstable during the hard state. This suggests that photoionization instability plays a key role in defining the observable properties of the ionized absorber. The same process might explain the disappearance of the high ionization absorber/wind, during the hard state in other accreting neutron stars and black holes.
description: 9 pages, 7 figures, accepted for publication in MNRAS
ГРАЖДАНСКОЕ ОБЩЕСТВО В РОССИЙСКОЙ ФЕДЕРАЦИИ КАК ФАКТОР ДЕМОКРАТИЧЕСКОГО РАЗВИТИЯ ГОСУДАРСТВА
Creators: name: ЦЕЛЫКОВСКИЙ ИГОРЬ ВЛАДИМИРОВИЧ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: ГРАЖДАНСКОЕ ОБЩЕСТВО
ДЕМОКРАТИЧЕСКОЕ ГОСУДАРСТВО
ПРАВА ГРАЖДАНИНА
КОНСТИТУЦИЯ
КОНСТИТУЦИОНАЛИЗМ
CIVIL SOCIETY
DEMOCRATIC STATE
RIGHTS OF THE CITIZEN
CONSTITUTION
CONSTITUTIONALISM

description: В статье анализируется важность развития гражданского общества и его влияние на политические, экономические и социальные права граждан. Автор исходит из того, что гражданское общество обязано оказывать влияние на проводимую политику государства во всех сферах деятельности. В свою очередь, государство обязано учитывать настроение граждан при разработке и проведении политических, правовых, экономических и социальных преобразований. Представляется важным и необходимым наличие диалога между государством и гражданским обществом.
Microwave Current Imaging in Passive HTS Components by Low-Temperature Laser Scanning Microscopy (LTLSM)
Creators: name: Zhuravel, A. P.
name: Anlage, Steven M.
name: Ustinov, A. V.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have used the LTLSM technique for a spatially resolved investigation of the microwave transport properties, nonlinearities and material inhomogeneities in an operating coplanar waveguide YBa_2Cu_3O_{7-δ} (YBCO) microwave resonator on an LaAlO_3 (LAO) substrate. The influence of twin-domain blocks, in-plane rotated grains, and micro-cracks in the YBCO film on the nonuniform rf current distribution were measured with a micrometer-scale spatial resolution. The impact of the peaked edge currents and rf field penetration into weak links on the linear device performance were studied as well. The LTLSM capabilities and its future potential for non-destructive characterization of the microwave properties of superconducting circuits are discussed.
description: 8 pages, 9 figures, 2-column format, presented at High Temperature Superconductors in High Frequency Fields 2004, Journal of Superconductivity (in press)
A Parametric Study of the SASI Comparing General Relativistic and Nonrelativistic Treatments
Creators: name: Dunham, Samuel J.
name: Endeve, Eirik
name: Mezzacappa, Anthony
name: Blondin, John M.
name: Buffaloe, Jesse
name: Holley-Bockelmann, Kelly
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We present numerical results from a parameter study of the standing accretion shock instability (SASI), investigating the impact of general relativity (GR) on the dynamics. Using GR hydrodynamics with GR gravity, and nonrelativistic (NR) hydrodynamics with Newtonian gravity, in an idealized model setting, we vary the initial radius of the shock and, by varying its mass and radius in concert, the proto-neutron star (PNS) compactness. We investigate four compactnesses expected in a post-bounce core-collapse supernova (CCSN). We find that GR leads to a longer SASI oscillation period, with ratios between the GR and NR cases as large as 1.29 for the highest-compactness suite. We also find that GR leads to a slower SASI growth rate, with ratios between the GR and NR cases as low as 0.47 for the highest-compactness suite. We discuss implications of our results for CCSN simulations.
description: 21 pages, 11 figures. Updated to match published version
title: ADCO, Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Cart. 176 (11 H 8), f. 0004
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 176 (11 H 8), f. 0004, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 176 (11 H 8), f. 0004, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
ДЕМОКРАТИЧЕСКИЙ РЕЖИМ В РОССИЙСКОЙ ФЕДЕРАЦИИ. ИСТОРИЯ СТАНОВЛЕНИЯ
Creators: name: ДАДАЕВ АНЗОР СУЛЕЙМАНОВИЧ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: КОНСТИТУЦИЯ РФ
ДЕМОКРАТИЧЕСКИЙ РЕЖИМ
ПОЛИТИЧЕСКИЕ ИНСТИТУТЫ
ПРАВОВАЯ КУЛЬТУРА
ПРИОРИТЕТНОСТЬ ДЕМОКРАТИИ
CONSTITUTION OF THE RUSSIAN FEDERATION
DEMOCRATIC REGIME
POLITICAL INSTITUTIONS
LEGAL CULTURE
THE PRIORITY DEMOCRACY

description: Предметом исследования являются особенности и тенденции развития демократии в ближайшем будущем. Целью данной статьи является выявление основных проблем демократии в Российской Федерации. Проанализированы характерные особенности становления демократического режима в стране. На основе проведенного исследования автором предлагается использовать исторический метод для наиболее эффективного поиска решения проблем. Сделаны выводы относительно индивидуального подхода к демократизации российского общества.
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein.
Creators: name: Belan, Ondrej
name: Greenhough, Luke
name: Kuhlen, Lucas
name: Anand, Roopesh
name: Kaczmarczyk, Artur
name: Gruszka, Dominika T
name: Yardimci, Hasan
name: Zhang, Xiaodong
name: Rueda, David S
name: West, Stephen C
name: Boulton, Simon J
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Genome Integrity & Repair
subject: Genome Integrity & Repair
classificationCode: Model organisms
subject: Model organisms
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Structural Biology & Biophysics
subject: Structural Biology & Biophysics
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Imaging
subject: Imaging
classificationCode: Cell Cycle & Chromosomes
subject: Cell Cycle & Chromosomes

description: Homologous recombination (HR) is essential for error-free repair of DNA double-strand breaks, perturbed replication forks (RFs), and post-replicative single-stranded DNA (ssDNA) gaps. To initiate HR, the recombination mediator and tumor suppressor protein BRCA2 facilitates nucleation of RAD51 on ssDNA prior to stimulation of RAD51 filament growth by RAD51 paralogs. Although ssDNA binding by BRCA2 has been implicated in RAD51 nucleation, the function of double-stranded DNA (dsDNA) binding by BRCA2 remains unclear. Here, we exploit single-molecule (SM) imaging to visualize BRCA2-mediated RAD51 nucleation in real time using purified proteins. We report that BRCA2 nucleates and stabilizes RAD51 on ssDNA either directly or through an unappreciated diffusion-assisted delivery mechanism involving binding to and sliding along dsDNA, which requires the cooperative action of multiple dsDNA-binding modules in BRCA2. Collectively, our work reveals two distinct mechanisms of BRCA2-dependent RAD51 loading onto ssDNA, which we propose are critical for its diverse functions in maintaining genome stability and cancer suppression.
Electrical resistivity across the tricriticality in itinerant ferromagnet
Creators: name: Opletal, Petr
name: Prokleška, Jan
name: Valenta, Jaroslav
name: Sechovský, Vladimír
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate the discontinuous ferromagnetic phase diagram near tricritical point in UCo 1-x Ru x Al compounds by electrical resistivity measurements. Separation of phases in UCo 0.995 Ru 0.005 Al at ambient pressure and in UCo 0.990 Ru 0.010 Al at pressure of 0.2 GPa and disappearance of ferromagnetism at 0.4 GPa is confirmed. The exponent of temperature dependence of electrical resistivity implies change from Fermi liquid behavior to non-Fermi liquid at 0.2 GPa and reaches minimum at 0.4 GPa. Our results are compared to results obtained on the pure UCoAl and explanation for different exponents is given.
ОСОБЕННОСТИ ДЕЯТЕЛЬНОСТИ ИНТЕРПОЛА КАК МЕЖДУНАРОДНОЙ ПОЛИЦЕЙСКОЙ ОРГАНИЗАЦИИ УНИВЕРСАЛЬНОГО УРОВНЯ
Creators: name: АЛИЕВА МАДИНА НИЗАМОВНА
name: ГАДЖИЕВ ЮНУС АЛИБУЛАТОВИЧ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: ИНТЕРПОЛ
ПРАВОПОРЯДОК
СИСТЕМА УВЕДОМЛЕНИЙ
МЕЖДУНАРОДНЫЙ ПОИСК
МЕЖДУНАРОДНЫЕ ПРЕСТУПЛЕНИЯ
INTERPOL
LAW AND ORDER
NOTIFICATION SYSTEM
INTERNATIONAL SEARCH
INTERNATIONAL OFFENSES

description: Статья посвящена роли Интерпола в международном сотрудничестве в борьбе с преступностью. Проводится анализ деятельности и методов борьбы Интерпола с преступностью. Перечислены проблемы в деятельности Интерпола. Сделаны выводы о значимости его деятельности для пресечения, раскрытия и расследования преступлений.
The Interplay of Machine Learning--based Resonant Anomaly Detection Methods
Creators: name: Golling, Tobias
name: Kasieczka, Gregor
name: Krause, Claudius
name: Mastandrea, Radha
name: Nachman, Benjamin
name: Raine, John Andrew
name: Sengupta, Debajyoti
name: Shih, David
name: Sommerhalder, Manuel
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Machine learning--based anomaly detection (AD) methods are promising tools for extending the coverage of searches for physics beyond the Standard Model (BSM). One class of AD methods that has received significant attention is resonant anomaly detection, where the BSM is assumed to be localized in at least one known variable. While there have been many methods proposed to identify such a BSM signal that make use of simulated or detected data in different ways, there has not yet been a study of the methods' complementarity. To this end, we address two questions. First, in the absence of any signal, do different methods pick the same events as signal-like? If not, then we can significantly reduce the false-positive rate by comparing different methods on the same dataset. Second, if there is a signal, are different methods fully correlated? Even if their maximum performance is the same, since we do not know how much signal is present, it may be beneficial to combine approaches. Using the Large Hadron Collider (LHC) Olympics dataset, we provide quantitative answers to these questions. We find that there are significant gains possible by combining multiple methods, which will strengthen the search program at the LHC and beyond.
description: 27 pages, 21 figures. Updated with revisions for journal acceptance
ПРАВО НА ОБРАЗОВАНИЕ В РЕГИОНАЛЬНЫХ МЕЖДУНАРОДНЫХ АКТАХ И КОНСТИТУЦИЯХ АРАБСКИХ ГОСУДАРСТВ
Creators: name: АЛ КХАФАДЖИ МОХАММЕД АБДУЛАДХИМ НИМАХ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: ПРАВО НА ОБРАЗОВАНИЕ
УНИВЕРСАЛЬНЫЕ АКТЫ ПО ПРАВАМ ЧЕЛОВЕКА
РЕГИОНАЛЬНЫЕ АКТЫ И КОНСТИТУЦИИ АРАБСКИХ ГОСУДАРСТВ
THE RIGHT TO EDUCATION
UNIVERSAL HUMAN RIGHTS INSTRUMENTS
REGIONAL ACTS AND CONSTITUTIONS OF THE ARAB STATES

description: Право на образование является естественным и неотчуждаемым правом каждого человека, получившим закрепление в универсальных международных актах по правам человека. Региональные акты и конституции арабских государств подтверждают право на образование, однако его интерпретация и реализация осуществляются с учетом традиционных исламских ценностей.
Massive Stars in the Range $\rm 13-25 M_\odot$: Evolution and Nucleosynthesis. II. the Solar Metallicity Models
Creators: name: Limongi, M.
name: Straniero, O.
name: Chieffi, A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the evolutionary properties of a set of massive stellar models (namely 13, 15, 20 and 25 $\rm M_\odot$) from the main sequence phase up to the onset of the iron core collapse. All these models have initial solar chemical composition, i.e. Y=0.285 and Z=0.02. A 179 isotope network, extending from neutron up to $\rm ^{68}Zn$ and fully coupled to the evolutionary code has been adopted from the Carbon burning onward. Our results are compared, whenever possible, to similar computations available in literature.
description: 42 pages, 18 figures, 26 tables, accepted for publicatin in ApJS
МЕЖДУНАРОДНЫЕ СТАНДАРТЫ ПО ОБЕСПЕЧЕНИЮ КОНСТИТУЦИОННОГО ПРАВА НА НЕПРИКОСНОВЕННОСТЬ ЛИЧНОСТИ В РЕСПУБЛИКЕ ТАДЖИКИСТАН
Creators: name: МИРЗОЕВ РАСУЛ ДЖУРАХОНОВИЧ
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: МЕЖДУНАРОДНЫЕ СТАНДАРТЫ
НЕПРИКОСНОВЕННОСТЬ ЛИЧНОСТИ
ПРАВА ЧЕЛОВЕКА
КОНСТИТУЦИОННЫЕ МЕХАНИЗМЫ
ПРАВООХРАНИТЕЛЬНАЯ ДЕЯТЕЛЬНОСТЬ
ЗАПРЕТ ПЫТОК
УВАЖИТЕЛЬНОЕ ОТНОШЕНИЕ
INTERNATIONAL STANDARDS
PERSONAL INTEGRITY
HUMAN RIGHTS
CONSTITUTIONAL MECHANISMS
LAW ENFORCEMENT
PROHIBITION OF TORTURE
RESPECTFUL ATTITUDE

description: В статье рассматриваются состояние и проблемы реализации международных стандартов на неприкосновенность личности в Таджикистане. Приводится авторское определение международных стандартов в сфере прав человека, указываются источники международных стандартов неприкосновенности личности, отмечается наличие в Республике Таджикистан современного юридического механизма обеспечения и гарантий прав. В числе основных проблем и задач выделяются: развитие транспаретности правоохранительной деятельности в связи с реализацией конституционных гарантий на неприкосновенность личности; проблематика установления в рамках ЕАЭС единых нормативных стандартов неприкосновенности личности и унифицированного механизма обеспечения их исполнения с учетом актуальных интересов обеспечения национальной и общественной безопасности и защиты от террористической угрозы и организованной преступности.
Single-particle excitations across the localization and many-body localization transition in quasi-periodic systems
Creators: name: Prasad, Yogeshwar
name: Garg, Arti
Publisher: name: arXiv
Year: 2023
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study localization and many-body localization transition in one dimensional systems in the presence of deterministic quasi-periodic potential. We use single-particle excitations obtained through single-particle Green's function in real space to characterize the localization to delocalization transition. A single parameter scaling analysis of the ratio of the typical to average value of the local density of states (LDOS) of single particle excitations shows that the critical exponent with which the correlation length $ξ$ diverges at the transition point $ξ\sim |h-h_c|^{-ν}$, coming from the localized side, satisfies the inequality $ν\ge 1$ for the non-interacting Aubry-Andre (AA) model. For the interacting system with AA potential, we study single particle excitations produced in highly excited many-body eigenstates across the MBL transition and found that the critical exponent obtained from finite-size scaling of the ratio of the typical to average value of the LDOS satisfies $ν\ge 1$ here as well. This analysis of local density of states shows that the localization and MBL transition in systems with quasi-periodic potential belong to a different universality class than the localization and MBL transition in systems with random disorder where $ν\ge 2$. In complete contrast to this, finite-size scaling of the level spacing ratio is known to support the same universality class for MBL transitions in systems with quasiperiodic as well as random disorder potentials. For the interacting systems with quasiperiodic potentials, though finite-size scaling of the level spacing ratio shows a transition at $h_c^{lsr}$ which is close to the transition point obtained from LDOS within numerical precision, the critical exponent obtained from finite-size scaling of level spacing ratio is $ν\sim 0.54$ in close similarity to the MBL systems with random disorder.
description: 7 pages, 5 figures
Delineating Classes of Computational Complexity via Second Order Theories with Weak Set Existence Principles (I)
Creators: name: Ignjatović, Aleksandar
Publisher: name: Carnegie Mellon University
Year: 1994
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: Aleksandar Ignjatović. Delineating Classes of Computational Complexity via Second Order Theories with Weak Set Existence Principles (I).
title: Structure-Guided Development of MAD22 as a Next-Generation RXR Agonist
Creators: name: Lewandowski, Max
name: Granger-Rivière, Marie
name: Mayer, Domenic
name: Marschner, Julian
name: Merk, Daniel
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2025
Subjects: subject: 615
subject: 610

description: Retinoid X receptors (RXRα, RXRβ, RXRγ) are ligand-activated transcription factors acting as universal nuclear receptor heterodimer partners, and regulating cell proliferation, differentiation, metabolism and inflammation. RXRs hold therapeutic potential in multiple indications like metabolic and inflammatory diseases, cancer and neurodegeneration. However, adverse effects of synthetic RXR agonists (so-called rexinoids), which are due to a lack of RXR (subtype) selectivity, as well as poor physicochemical and pharmacokinetic properties, hinder their application beyond second-line cancer treatment. To address limitations of traditional rexinoids, we developed a novel pyrimidine-based RXR agonist lead, JP147 (1), with improved properties and slight RXRα preference. Guided by the co-crystal structure of 1 bound to RXRα (PDB ID: 8pp0), we conducted systematic structure-activity relationship (SAR) studies and identified the highly potent RXR partial agonist ML197 (2) bearing a 4,4-dimethyl-1,2,3,4-tetrahydroquinoline motif in the 6' pyrimidine position. Further modifications revealed β-alanine as optimal substituent for the 2' position and trifluoromethyl for the 4' position. Structural fusion based on all SAR knowledge yielded the RXR agonist MAD22 (3) exhibiting single-digit nanomolar potency (EC50 (RXRα) 3.0 nM), no cytotoxicity, and >100-fold selectivity over nuclear receptors related to or forming dimers with RXR. High-affinity binding to RXR (Kd 0.008 µM) was confirmed by isothermal titration calorimetry (ITC), and reporter gene assays using the response elements DR1 and RARE demonstrated strong preference for the RXR homodimer (0.002 µM). Additionally, 3 revealed remarkable physicochemical and pharmacokinetic characteristics including superior aqueous solubility (114 µM, >260-fold higher than bexarotene) and high microsomal stability (t1/2 >2h). These results highlight 3 as a next-generation RXR agonist with exceptional drug-like properties.
Smooth Loops, Generalized Coherent States and Geometric Phases
Creators: name: Nesterov, Alexander I.
name: Sabinin, Lev V.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A description of generalized coherent states and geometric phases in the light of the general theory of smooth loops is given.
description: LATeX file, 11 pages
ЗАКЛЮЧЕНИЕ ЭКСПЕРТА-ЭКОЛОГА КАК ОБЪЕКТ АВТОРСКИХ ПРАВ
Creators: name: МАЙОРОВА ЕЛЕНА ИВАНОВНА
name: СТРЕЛЬНИКОВА ИРИНА АЛЕКСАНДРОВНА
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: СЛУЖЕБНОЕ ПРОИЗВЕДЕНИЕ
ЗАКЛЮЧЕНИЕ ЭКСПЕРТА-ЭКОЛОГА
ЭКСПЕРТИЗА
АВТОРСКОЕ ПРАВО
WORK-FOR-HIRE
THE CONCLUSION OF ENVIRONMENTAL EXPERT
EXPERTISE
COPYRIGHT LAW

description: В статье анализируется проблематика подготовки заключения эксперта-эколога и его правовое значение с точки зрения авторского права. Исследуется вопрос о заключении эксперта-эколога как служебного произведения и как официального документа государственного органа.
A Model of Polarisation Rotations in Blazars from Kink Instabilities in Relativistic Jets
Creators: name: Nalewajko, Krzysztof
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: This paper presents a simple model of polarisation rotation in optically thin relativistic jets of blazars. The model is based on the development of helical (kink) mode of current-driven instability. A possible explanation is suggested for the observational connection between polarisation rotations and optical/gamma-ray flares in blazars, if the current-driven modes are triggered by secular increases of the total jet power. The importance of intrinsic depolarisation in limiting the amplitude of coherent polarisation rotations is demonstrated. The polarisation rotation amplitude is thus very sensitive to the viewing angle, which appears to be inconsistent with the observational estimates of viewing angles in blazars showing polarisation rotations. Overall, there are serious obstacles to explaining large-amplitude polarisation rotations in blazars in terms of current-driven kink modes.
description: 6 pages, 3 figures; Proceedings of the conference "Polarised Emission from Astrophysical Jets", 12-16 June 2017, Ierapetra, Greece; Eds. M. Boettcher, E. Angelakis and J. L. G\'{o}mez
Study of hyperfine anomaly in $^9$Be within three-cluster model
Creators: name: Parfenova, Y. L.
name: Leclercq-Willain, Ch.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The study of the hyperfine (hfs) anomaly in neutron rich nuclei can give a very specific and unique way to study the neutron distribution and the clustering structure. We study the sensitivity of the hfs anomaly to the clustering effects in the 9Be isotope using two different nuclear wave functions obtained in the three-cluster (alpha+alpha+n) model. The results are compared to those obtained for 9,11Be in a two-body core + neutron model to examine whether the hfs anomaly is sensitive to a halo structure in 11Be.
description: 7 pages, 2 figures
ОБ ОСОБЕННОСТЯХ ОПРЕДЕЛЕНИЯ РАЗМЕРА КОМПЕНСАЦИИ МОРАЛЬНОГО ВРЕДА ПО РОССИЙСКОМУ ЗАКОНОДАТЕЛЬСТВУ
Creators: name: АХЪЯДОВ ЭЛЬМАН САИД-МОХМАДОВИЧ
name: САЛГИРИЕВА ЖАНАТИ АДАМОВНА
Publisher: name: Государственная служба и кадры
Year: 2019
Subjects: МОРАЛЬНЫЙ ВРЕД
МОРАЛЬНАЯ КОМПЕНСАЦИЯ
РАЗМЕР МОРАЛЬНОЙ КОМПЕНСАЦИИ
ПРОБЛЕМЫ МОРАЛЬНОЙ КОМПЕНСАЦИИ
MORAL DAMAGE
MORAL COMPENSATION
AMOUNT OF MORAL COMPENSATION
PROBLEMS OF MORAL COMPENSATION

description: В России институт возмещения морального вреда молодой институт, и его нормы не определяют пределов суммы компенсации, предоставляя это решение на рассмотрение суда. В статье рассмотрены основные принципы, критерии, а также проблемы установления размеров компенсации морального вреда, сформулированы предложения по их решению.