cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Wiedemannia (Philolutra) pseudovaillanti Joost
Creators: name: Kustov, Semen
name: Zherebilo, Danil
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Wiedemannia
Wiedemannia pseudovaillanti

description: Wiedemannia (Philolutra) pseudovaillanti Joost
(Fig. 13)
Wiedemannia (Philolutra) pseudovaillanti Joost, 1981: 188.
Material examined. RUSSIA: Karachay-Cherkess Republic, env. Rozhkao (13), 8.vi.2013, D. Zherebilo (2 ♂, 11 ♀); Krasnodarskiy Territory, Nature Reserve “Kamyshanova Polyana” (5), 24.06.2013, S.Yu. Kustov (3 ♂, 9 ♀); same data, 3.v.2015, S.Yu. Kustov, D. Zherebilo (2 ♀); Nature Reserve “Kamyshanova Polyana” (7), 2.v.2014, S.Yu. Kustov (2 ♂); Nature Reserve “Kamyshanova Polyana” (8), 4.v.2014, S.Yu. Kustov (3 ♀); same data, 17.vii.2014, V.V. Gladun (2 ♂, 3 ♀); same data, 19.vii.2014, V.V. Gladun (1 ♂, 2 ♀); same data, 6.ix.2014, S.Yu. Kustov (3 ♂, 2 ♀); same data, 2.v.2015, S.Yu. Kustov, D. Zherebilo (6 ♀); Nature Reserve “Kamyshanova Polyana” (6), 1.vi.2014, S.Yu. Kustov (1 ♂); same data, 17.vii.2014, Е. Pavlova, (1 ♀); env. Guamka (3), 30.04.2015, D. Zherebilo (2 ♂, 1 ♀). GEORGIA: Samtskhe-Javakheti (29), 20.iv.2014, D. Zherebilo (1 ♂); Shavsheti ridge (24), 4.iv.2015, A.V. Zherebilo (2 ♂); env. Hihadziri (33), 06.iv.2015, A.V. Zherebilo (5 ♂, 10 ♀); env. Chinkadziebi, 360 m a.s.l., 06.iv.2015, A.V. Zherebilo (1 ♀); env. Zedachukhuneti (27), 07.iv.2015, A.V. Zherebilo (2 ♂, 1 ♀); env. Chaisubani (26), 08.iv.2015, A.V. Zherebilo (3 ♂, 5 ♀); env. Zedakinchha (34), 09.iv.2015, A.V. Zherebilo (1 ♂, 1 ♀); env. Opitara (35), 10.iv.2015, A.V. Zherebilo (1 ♂); env. Chkumi (36), 11.iv.2015, A.V. Zherebilo (2 ♂, 1 ♀). ABKHAZIA: River Kelasuri (21), 12.iv.2014, D. Zherebilo (1 ♂).
Diagnosis. This species is distinguished by the completely dark brown scutum, acrostichals divergent around the prescutellar depression, 5–6 pairs of dorsocentrals with few intermediate setae, scutellum with several marginal setulae, fore femur apically without strong anterior setae; clasping cercus with anterior lobe short, pointed, bearing cluster of apical setae; dorsal process subtriangular, inner margin clothed in dense setae.
Distribution. PALAEARCTIC: Caucasus: Russia (Krasnodarsky Territory, Karachay-Cherkess Republic), Georgia, Abkhazia.
Remarks. Joost (1981) reported this species from the territory of Russian Caucasus—Dombai and Teberda, but Chvála & Wagner (1989) in the Catalogue of Palaearctic Diptera mistakenly indicated the species only from the Georgian territory. Therefore the species is noted for Georgia and Abkhazia for the first time. This species is commonly known from mountain rivers at elevations from 288–1500 m a.s.l. and is active from April to July.
description: Published as part of Kustov, Semen & Zherebilo, Danil, 2015, New data on the genus Wiedemannia Zetterstedt (Diptera: Empididae) from the Caucasus with description of four new species, pp. 351-369 in Zootaxa 4032 (4) on pages 364-365, DOI: 10.11646/zootaxa.4032.4.1, http://zenodo.org/record/243485
title: A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly
Creators: name: Kong, Daming
name: Roberts, Jason A.
name: Lipman, Jeffrey
name: Taccone, Fabio Silvio
name: Cohen-Wolkowiez, Michael
name: Sime, Fekade B.
name: Tsai, Danny
name: Cock, Pieter A. J. G. De
name: Jaruratanasirikul, Sutep
name: Michelet, Robin
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Pharmacokinetic Analysis
subject: Piperacillin/Tazobactam
subject: Different Patient Populations
classificationCode: 615
subject: Pharmakologie, Therapeutik

description: Background and Objectives The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (fUNB_PIP). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life. Methods Population PK models were separately built for PIP and TAZ based on data from 13 studies in various patient populations. In the development of those single-drug models, postnatal age (PNA), postmenstrual age (PMA), total body weight (TBW), height, and serum creatinine (SCR) were tested as covariates. Subsequently, a combined population PK model was established and the correlations between the PK of PIP and TAZ were tested. Monte Carlo simulations were performed based on the final combined model to evaluate the current dosing recommendations. Results The final combined model for PIP/TAZ consisted of four compartments (two for each drug), with covariates including TBW, PMA, and SCR. For a 70-kg, 35-year-old patient with SCR of 0.83 mg L−1, the PIP values for V1, CL, V2 and Q2 were 10.4 L, 10.6 L h−1, 11.6 L and 15.2 L h−1, respectively, and the TAZ values were 10.5 L, 9.58 L h−1, 13.7 L and 16.8 L h−1, respectively. The CL for both drugs show maturation in early life, reaching 50% at 54.2 weeks PMA. With advancing age, CL of TAZ declines to 50% at 61.6 years PMA, whereas CL of PIP declines more slowly, reaching 50% at 89.1 years PMA. The fUNB_PIP was estimated as 64.5% and non-linear elimination was not supported by our data. The simulation results indicated considerable differences in PK/PD target attainment for different patient populations under current recommended dosing regimens. Conclusions We developed a combined population PK model for PIP/TAZ across a broad range of patients covering the extremes of patient characteristics. This model can be used as a robust a priori model for Bayesian forecasting to achieve individualised dosing. The simulations indicate that adjustments based on the allometric theory as well as maturation and decline of CL of PIP may help the current dosing recommendations to provide consistent target attainment across patient populations.
Cestoplana rubrocincta Lang 1884
Creators: name: Noreña, Carolina
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Rhabditophora
Polycladida
Cestoplanidae
Cestoplana
Cestoplana rubrocincta

description: Cestoplana rubrocincta (Grube, 1840) Lang 1884
(Fig. 11 Q)
Orthostomum rubrocinctum Grube, 1840, 56 Orthostoma rubrocincta (Grube, 1840) Örsted 1844, 75 Typhlolepta rubrocincta (Grube, 1840) Stimpson 1857, 3 Cestoplana australis Haswell, 1907, 479, fig.
Cestoplana filiformis Laidlaw, 1903, 110
Type locality. Mediterranean Sea (Grube 1840).
Distribution. Kenya (Laidlaw 1903); Cape Verde (Laidlaw 1906); Susaki and Seto, Japan (Kato 1937); Naples and Sicily, Italy (Kato 1944); Port Jackson, Australia (Kato 1944); Bay Weligama, Sri Lanka (Kato 1944); Bay Gaira, Colombia (Quiroga 2008); Canary Archipelago: El Medano, Tenerife (De Vera et al. 2009) (Fig. 1, T4; Table 1 and 2).
Biology. De Vera and collaborators (2009) found Cestoplana rubrocinta in the intertidal zone at depths of 1 metre, in the spring time.
Taxonomic remarks. Characterised by an elongated, ribbon-shaped body, background colour pale orange, almost transparent or whitish, and three thin orange longitudinal lines, two marginal and one along the middle longitudinal body. Without tentacles or pseudotentacles.
description: Published as part of Noreña, Carolina, 2017, The Polycladida (Platyhelminthes) of the Canary Islands. New genus, species and records in Zootaxa 4312 (1), DOI: 10.11646/zootaxa.4312.1.2, http://zenodo.org/record/852062
Wiedemannia shamshevi Kustov & Zherebilo
Creators: name: Kustov, Semen
name: Zherebilo, Danil
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Wiedemannia
Wiedemannia shamshevi

description: Wiedemannia shamshevi Kustov & Zherebilo
(Fig. 14)
Wiedemannia shamshevi Kustov & Zherebilo, 2014: 166.
Material examined. GEORGIA: Lechkhumi ridge (41), 29.iv.2014, D. Zherebilo (1 ♂, 1 ♀); Khevsureti (47), 19.vii.2014, D. Zherebilo (32 ♂, 54 ♀); same locality, western slope of Chokismta-Matura (49), 23.vii.2014, D. Zherebilo (41 ♂, 67 ♀). SOUTH OSSETIA: Gudissky ridge (44), 21.vii.2013, D. Zherebilo (6 ♂, 6 ♀).
Diagnosis. This species is distinguished by the weak ocellar bristles, nearly twice shorter than postpronotal bristles, scutum brown with blue pruinescence on postpronotal lobe and notopleuron, acrostichals extending to third dorsocentral seta, 5 pairs of dorsocentrals without intermediate setae interspersed among primary setae, fore femur without strong bristles apically; terminalia large, clasping cercus long and unilobed, projecting perpendicular to epandrium.
Distribution. PALAEARCTIC: Caucasus: Georgia, South Ossetia.
Remarks. This high-mountain species is active from April to July, and is common in high-altitude streams and rivers (2500–3000 m a.s.l.), but is known from lower elevations (770 m a.s.l) in early spring.
description: Published as part of Kustov, Semen & Zherebilo, Danil, 2015, New data on the genus Wiedemannia Zetterstedt (Diptera: Empididae) from the Caucasus with description of four new species, pp. 351-369 in Zootaxa 4032 (4) on page 365, DOI: 10.11646/zootaxa.4032.4.1, http://zenodo.org/record/243485
Multisepta Noreña 2017, n. gen.
Creators: name: Noreña, Carolina
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Rhabditophora
Polycladida
Cryptocelidae
Multisepta

description: Genus Multisepta n. gen.
Definition. Cryptocelidae with tentacles; tentacular and cerebral eye clusters present. Male copulatory apparatus with true seminal vesicle and complicated armed penis stylet. Prostatic vesicle strong muscular, with fibrous transversal septa proximally and tubular longitudinal septa distally. Gonopores separated. Female complex with bulbous vagina; Lang's vesicle present.
Etymology. From the Latin, multiplex (multiple) and septum (partition) in relation to the unique structure of the prostatic vesicle.
description: Published as part of Noreña, Carolina, 2017, The Polycladida (Platyhelminthes) of the Canary Islands. New genus, species and records in Zootaxa 4312 (1), DOI: 10.11646/zootaxa.4312.1.2, http://zenodo.org/record/852062
Under A Green Sea Experiences Of Gas Warfare
Creators: name: Project Team, World War I Centenary
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Article contributed to the 'World War I Centenary: Continuations and Beginnings' project.The 'World War I Centenary: Continuations and Beginnings' project ran with contributions from 2012 to 2020. It was an open-access online platform offering free-to-use materials under a Creative Commons Attribution Non-Commercial Sharealike Licence. The project aimed to represent future directions in teaching First World War Studies, challenge existing misconceptions about the conflict, and reappraise the War in its social, cultural, historical, and political contexts. Contributions came from leading academic and non-academic experts, as well as student ambassadors, and include scholarly articles, short talks, lectures, ebooks, innovative computer models, and interactive maps. Funded by the JISC WW1 Open Educational Resources Programme and supported by the JISC 'Statement of Intent', this resource was a collaboration between the University of Oxford teams behind the First World War Poetry Digital Archive, the Great War Archive, and various other educational initiatives. The project's interdisciplinary approach and diverse materials aimed to bring the events, people, and places of World War I into sharp relief for educational and research purposes.
title: A litmus test for classifying recognition mechanisms of transiently binding proteins
Creators: name: Chakrabarti, Kalyan S.
name: Olsson, Simon
name: Pratihar, Supriya
name: Giller, Karin
name: Overkamp, Kerstin
name: Lee, Ko On
name: Gapsys, Vytautas
name: Ryu, Kyoung-Seok
name: Groot, Bert L. De
name: Noé, Frank
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Computational models
subject: Molecular modelling
subject: Solution-state NMR
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Partner recognition in protein binding is critical for all biological functions, and yet, delineating its mechanism is challenging, especially when recognition happens within microseconds. We present a theoretical and experimental framework based on straight-forward nuclear magnetic resonance relaxation dispersion measurements to investigate protein binding mechanisms on sub-millisecond timescales, which are beyond the reach of standard rapid-mixing experiments. This framework predicts that conformational selection prevails on ubiquitin’s paradigmatic interaction with an SH3 (Src-homology 3) domain. By contrast, the SH3 domain recognizes ubiquitin in a two-state binding process. Subsequent molecular dynamics simulations and Markov state modeling reveal that the ubiquitin conformation selected for binding exhibits a characteristically extended C-terminus. Our framework is robust and expandable for implementation in other binding scenarios with the potential to show that conformational selection might be the design principle of the hubs in protein interaction networks.
Diversinervus Silvestri 1915
Creators: name: Zuparko, Robert L.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Encyrtidae
Diversinervus

description: Diversinervus Silvestri 1915
Hosts. Hemiptera: Coccidae
elegans Silvestri 1915: 304
Type. DEZA
Distribution. E (Orange, Riverside, San Bernardino, San Diego, Santa Barbara, Ventura)
Host/habitat. Ceroplastes brevicauda, C. destructor, C. floridensis, C. rusci, C. sp., Coccus hesperidum, C. pseudomagnoliarum, Drepanococcus chiton, Eulecanium kunoense, Gascardia sp., Inglisia sp., Marsipococcus proteae, Parasaissetia nigra, Parthenolecanium corni, Pulvinaria floccifera, P. psidii, P. urbicola, Saissetia coffeae, S. oleae, S. persimilis, S. sp.
Remarks. The first effort to import this species (in a Saissetia oleae biocontrol program) into California was in 1931, but the stock perished in transit (Compere 1931). Successive importations (from Eritrea in 1953 and Lebanon in the mid-1960s) proved more successful, and it was released throughout the state (Lampson & Morse 1992). Initially, this species was recovered wherever S. oleae occurred in southern California (Bartlett & Medved 1966), but later studies found it only established in the coastal region of southern California (Kennett 1986; Lampson & Morse 1992), possibly as a result of being outcompeted by other imported natural enemies. Lampson and Morse (1992) suggested that D. elegans can act as a hyperparasitoid, but the detailed studies of Bartlett & Medved (1966) found no evidence of such (although second instar larvae will engage in combat to reduce the number of supernumeraries). Specimens from UCRC are recorded from Aonidiella aurantii, but I suspect these are misidentified.
description: Published as part of Zuparko, Robert L., 2015, Annotated Checklist of California Encyrtidae (Hymenoptera), pp. 1-126 in Zootaxa 4017 (1) on pages 26-27, DOI: 10.11646/zootaxa.4017.1.1, http://zenodo.org/record/245475
Ochthebius evanescens Sahlberg 1875
Creators: name: PROKIN, Alexander A.
name: LITOVKIN, Stanislav V.
name: JÄCH, Manfred A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius evanescens

description: Ochthebius (s.str.) evanescens Sahlberg, 1875
Recorded from the eastern part of Kazakhstan for the first time by Zinchenko (2015).
Russia (ST): Volgograd Oblast’, Lake Elton, pools near Lantsug River, 14 Apr 2008, leg. A. Prokin, 1 ex. (APC); Kazakhstan: 50°19'03.8''N, 57°26'09.6''E, 224 m, Aktyubinsk Oblast’, E of Aktobe (= Aktyubinsk), Zhaman-Karagaly River, 30 Apr 2015, leg. S. Litovkin, 1 ex. (SLC); 46°58'11.0''N, 61°29'27.5''E, 80 m, Kyzylorda Oblast’, 21 km NW Aral (= Aral’sk), desert, in brackish pools, 1–2 May 2015, leg. S. Litovkin, 4 ex. (SLC).
description: Published as part of PROKIN, Alexander A., LITOVKIN, Stanislav V. & JÄCH, Manfred A., 2015, New records of Hydraenidae and Elmidae (Coleoptera) from Russia and adjacent countries, pp. 99-110 in Fragmenta Faunistica 58 (2) on page 104, DOI: 10.3161/00159301FF2015.58.2.099, http://zenodo.org/record/6251830
Wartime Art And Grief
Creators: name: Project Team, World War I Centenary
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Article contributed to the 'World War I Centenary: Continuations and Beginnings' project.The 'World War I Centenary: Continuations and Beginnings' project ran with contributions from 2012 to 2020. It was an open-access online platform offering free-to-use materials under a Creative Commons Attribution Non-Commercial Sharealike Licence. The project aimed to represent future directions in teaching First World War Studies, challenge existing misconceptions about the conflict, and reappraise the War in its social, cultural, historical, and political contexts. Contributions came from leading academic and non-academic experts, as well as student ambassadors, and include scholarly articles, short talks, lectures, ebooks, innovative computer models, and interactive maps. Funded by the JISC WW1 Open Educational Resources Programme and supported by the JISC 'Statement of Intent', this resource was a collaboration between the University of Oxford teams behind the First World War Poetry Digital Archive, the Great War Archive, and various other educational initiatives. The project's interdisciplinary approach and diverse materials aimed to bring the events, people, and places of World War I into sharp relief for educational and research purposes.
FabuLight-ASD: Unveiling Speech Activity via Body Language
Creators: name: Carneiro, Hugo
name: Wermter, Stefan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Sound (cs.SD)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: I.2.0
subject: 68T20

description: Active speaker detection (ASD) in multimodal environments is crucial for various applications, from video conferencing to human-robot interaction. This paper introduces FabuLight-ASD, an advanced ASD model that integrates facial, audio, and body pose information to enhance detection accuracy and robustness. Our model builds upon the existing Light-ASD framework by incorporating human pose data, represented through skeleton graphs, which minimises computational overhead. Using the Wilder Active Speaker Detection (WASD) dataset, renowned for reliable face and body bounding box annotations, we demonstrate FabuLight-ASD's effectiveness in real-world scenarios. Achieving an overall mean average precision (mAP) of 94.3%, FabuLight-ASD outperforms Light-ASD, which has an overall mAP of 93.7% across various challenging scenarios. The incorporation of body pose information shows a particularly advantageous impact, with notable improvements in mAP observed in scenarios with speech impairment, face occlusion, and human voice background noise. Furthermore, efficiency analysis indicates only a modest increase in parameter count (27.3%) and multiply-accumulate operations (up to 2.4%), underscoring the model's efficiency and feasibility. These findings validate the efficacy of FabuLight-ASD in enhancing ASD performance through the integration of body pose data. FabuLight-ASD's code and model weights are available at https://github.com/knowledgetechnologyuhh/FabuLight-ASD.
description: 23 pages, 8 figures, 3 tables, accepted for publication in Neural Computing and Applications
Wiedemannia sinclairi Kustov & Zherebilo
Creators: name: Kustov, Semen
name: Zherebilo, Danil
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Wiedemannia
Wiedemannia sinclairi

description: Wiedemannia sinclairi Kustov & Zherebilo
(Fig. 15)
Wiedemannia sinclairi Kustov & Zherebilo, 2014: 167.
Material examined. RUSSIA: Krasnodarskiy Territory, Nature Reserve “Kamyshanova Polyana” (7), 9.vii.2009, V.V. Gladun (4 ♂, 1 ♀); same data, 2.v.2014, S.Yu. Kustov (1 ♀); Nature Reserve “Kamyshanova Polyana” (8), 11.vii.2013, V.V. Gladun (3 ♂, 5 ♀) Nature Reserve “Kamyshanova Polyana” (5), 24.vi.2013, S.Yu. Kustov (11 ♂, 12 ♀); Nature Reserve “Kamyshanova Polyana” (6), 23–25.vii.2013, S.Yu. Kustov (5 ♂, 3 ♀); same data, 1.vi.2014, S.Yu. Kustov (1 ♂); Karachay-Cherkess Republic, River Phiya (16), 10.vi.2013, D. Zherebilo (1 ♂); env. Phiya (15), 11.viii.2013, V.V Gladun, (2 ♀); same data, D. Zherebilo (2 ♂, 1 ♀); River Kislaya (14), 12.viii.2013, D. Zherebilo (1 ♂, 1 ♀). GEORGIA: Lechkhumi ridge (41), 28.iv.2014, D. Zherebilo (1 ♀); env. Lahepa (23), 29.iv.2014, D. Zherebilo (1 ♀); Mingrelia, env. Doberazeni (28), 435 m a.s.l. 2.v.2014, D. Zherebilo (11 ♂, 5 ♀); Mingrelia, ridge Ofitsari (30), 828 m a.s.l., 6.v.2014, D. Zherebilo (7 ♂, 6 ♀). ABKHAZIA: River Pshitsa (9), 11.vii.2013, D. Zherebilo (4 ♂, 4 ♀).
Diagnosis. This species is distinguished by the completely brown scutum, acrostichals divergent around prescutellar depression, 5 pairs of dorsocentrals with few interspersed shorter setae, fore femur apically without strong anterior setae; clasping cercus unilobed, large and subrectangular.
Distribution. PALAEARCTIC: Caucasus: Russia (Adygea Republic, Krasnodarsky Territory, Karachay- Cherkess Republic), Georgia, Abkhazia.
Remarks. The species is noted from the territory of Georgia for the first time. It is a common species, known from mountain rivers of the Caucasus from elevations between 435–1650 m a.s.l. and is active from April to August.
description: Published as part of Kustov, Semen & Zherebilo, Danil, 2015, New data on the genus Wiedemannia Zetterstedt (Diptera: Empididae) from the Caucasus with description of four new species, pp. 351-369 in Zootaxa 4032 (4) on pages 365-366, DOI: 10.11646/zootaxa.4032.4.1, http://zenodo.org/record/243485
title: Protein nanobarcodes enable single-step multiplexed fluorescence imaging
Creators: name: Jong-Bolm, Daniëlle De
name: Sadeghi, Mohsen
name: Bogaciu, Cristian A.
name: Bao, Guobin
name: Klaehn, Gabriele
name: Hoff, Merle
name: Mittelmeier, Lucas
name: Basmanav, F. Buket
name: Opazo, Felipe
name: Noé, Frank
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Transfection
subject: Fluorescence imaging
subject: Neural networks
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Multiplexed cellular imaging typically relies on the sequential application of detection probes, as antibodies or DNA barcodes, which is complex and time-consuming. To address this, we developed here protein nanobarcodes, composed of combinations of epitopes recognized by specific sets of nanobodies. The nanobarcodes are read in a single imaging step, relying on nanobodies conjugated to distinct fluorophores, which enables a precise analysis of large numbers of protein combinations. Fluorescence images from nanobarcodes were used as input images for a deep neural network, which was able to identify proteins with high precision. We thus present an efficient and straightforward protein identification method, which is applicable to relatively complex biological assays. We demonstrate this by a multicell competition assay, in which we successfully used our nanobarcoded proteins together with neurexin and neuroligin isoforms, thereby testing the preferred binding combinations of multiple isoforms, in parallel.
Echthroplexiella Mercet 1921
Creators: name: Zuparko, Robert L.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Encyrtidae
Echthroplexiella

description: Echthroplexiella Mercet 1921
spp.
Remarks. Until recently, this genus was known only from the Palearctic region, but Trjapitzin (2006) described a new species from Mexico, and reported another undescribed species from Pt. Reyes, Marin County (EMEC) (the collecting labels read “North Beach Turnoff, ungrazed plot”, not “North Beach Tarnhoff, ungra-zed plot” as reported by Trjapitzin). Additional specimens of this species were collected in Lassen, Marin, Nevada, Santa Barbara (RLZC) and San Bernardino (UCRC) counties. Specimens which appear to represent a second species were collected in Inyo County (UCRC).
description: Published as part of Zuparko, Robert L., 2015, Annotated Checklist of California Encyrtidae (Hymenoptera), pp. 1-126 in Zootaxa 4017 (1) on page 27, DOI: 10.11646/zootaxa.4017.1.1, http://zenodo.org/record/245475
Why July 1916 Was An Important Month For Professional Women
Creators: name: Project Team, World War I Centenary
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Article contributed to the 'World War I Centenary: Continuations and Beginnings' project.The 'World War I Centenary: Continuations and Beginnings' project ran with contributions from 2012 to 2020. It was an open-access online platform offering free-to-use materials under a Creative Commons Attribution Non-Commercial Sharealike Licence. The project aimed to represent future directions in teaching First World War Studies, challenge existing misconceptions about the conflict, and reappraise the War in its social, cultural, historical, and political contexts. Contributions came from leading academic and non-academic experts, as well as student ambassadors, and include scholarly articles, short talks, lectures, ebooks, innovative computer models, and interactive maps. Funded by the JISC WW1 Open Educational Resources Programme and supported by the JISC 'Statement of Intent', this resource was a collaboration between the University of Oxford teams behind the First World War Poetry Digital Archive, the Great War Archive, and various other educational initiatives. The project's interdisciplinary approach and diverse materials aimed to bring the events, people, and places of World War I into sharp relief for educational and research purposes.
Wiedemannia (Philolutra) vaillanti Joost
Creators: name: Kustov, Semen
name: Zherebilo, Danil
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Wiedemannia
Wiedemannia vaillanti

description: Wiedemannia (Philolutra) vaillanti Joost
(Fig. 16)
Wiedemannia (Philolutra) vaillanti Joost, 1981: 189.
Material examined. RUSSIA: Krasnodarskiy Territory, Nature Reserve “Kamyshanova Polyana” (7), 2.v.2014, S.Yu. Kustov (2 ♂, 1 ♀); Nature Reserve “Kamyshanova Polyana” (8), 4.v.2014, S.Yu. Kustov (11 ♂, 4 ♀); Nature Reserve “Kamyshanova Polyana” (6), 13.vi.2014, S.Yu. Kustov (4 ♂, 3 ♀). Karachay-Cherkess Republic, River Phiya (16), 10.vi.2013, D. Zherebilo (59 ♂, 47 ♀); env. Rozhkao (13), 8.vi.2013, D. Zherebilo (1 ♀); watershed of River Bolshaya Laba (12), 9.vi.2013, D. Zherebilo (2 ♂, 7 ♀). GEORGIA: Lechkhumi ridge (41), 28.iv.2014, D. Zherebilo (2 ♂, 1 ♀); Mingrelia, ridge Ofitsari (31), 3.v.2014, D. Zherebilo (2 ♂, 1 ♀); ridge Ofitsari (30), 4.v.2014, D. Zherebilo (1 ♂); same data, 6.v.2014, D. Zherebilo (4 ♂, 2 ♀); ridge Ofitsari (32), 5.v.2014, D. Zherebilo (1 ♂). ABKHAZIA: River Bzyb (20), 30.vi.2013, D. Zherebilo (3 ♂, 2 ♀); same data, 1.vii.2013, D. Zherebilo (41 ♂, 32 ♀).
Diagnosis. Wiedemannia (Philolutra) vaillanti differs by the completely dark brown scutum, acrostichals divergent around prescutellar depression, 5 pairs of dorsocentrals without interspersed shorter setae, fore femur apically without strong anterior setae; clasping cercus with anterior lobe prolonged, digitiform and slender, without cluster of apical setae; dorsal process anvil-shaped, inner margin without dense setae.
Distribution. PALAEARCTIC: Caucasus: Russia (Krasnodarsky Territory, Karachay-Cherkess Republic), Georgia, Abkhazia; Asia: Turkey (Bolu: Yedigöller National Park).
Remarks. This species was described by Joost (1981) from Tscheget, Terskol and Dombai (Russia: Kabardino-Balkaria Republic and Karachay-Cherkessia Republic), but Chvála & Wagner (1989) in the Catalogue of Palaearctic Diptera mistakenly indicated the species from the Georgian territory. Therefore W. vaillanti is noted from the territories of Georgia and Abkhazia for the first time. This common species is known from mountain rivers of the Caucasus from elevations between 780–2100 m a.s.l. and is active from April to July.
description: Published as part of Kustov, Semen & Zherebilo, Danil, 2015, New data on the genus Wiedemannia Zetterstedt (Diptera: Empididae) from the Caucasus with description of four new species, pp. 351-369 in Zootaxa 4032 (4) on page 366, DOI: 10.11646/zootaxa.4032.4.1, http://zenodo.org/record/243485
Ibogaine: An Update
Creators: name: Sameš, Dalibor
Publisher: name: Zenodo
Year: 2023
Subjects: chemistry
pharmacology
drug development
drugs
psychoactive
psychedelic
synthesis

description: Dalibor Sameš - Ibogaine: An Update 

(psychedelic molecules, 4th-5th September 2023, Prague, Czech Republic)
title: Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa
Creators: name: Dommisch, H.
name: Stolte, KN.
name: Jager, J.
name: Vogel, K.
name: Müller, R.
name: Hedtrich, S.
name: Unbehauen, Michael
name: Haag, Rainer
name: Danker, Kerstin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Core-multishell nanocarrier
subject: Transepithelial resistance
subject: Penetration
subject: Oral mucosal equivalents
classificationCode: 615
subject: Pharmakologie, Therapeutik

description: Objectives Topical drug administration is commonly applied to control oral inflammation. However, it requires sufficient drug adherence and a high degree of bioavailability. Here, we tested the hypothesis whether an ester-based core-multishell (CMS) nanocarrier is a suitable nontoxic drug-delivery system that penetrates efficiently to oral mucosal tissues, and thereby, increase the bioavailability of topically applied drugs. Material and methods To evaluate adhesion and penetration, the fluorescence-labeled CMS 10-E-15-350 nanocarrier was applied to ex vivo porcine masticatory and lining mucosa in a Franz cell diffusion assay and to an in vitro 3D model. In gingival epithelial cells, potential cytotoxicity and proliferative effects of the nanocarrier were determined by MTT and sulphorhodamine B assays, respectively. Transepithelial electrical resistance (TEER) was measured in presence and absence of CMS 10-E-15-350 using an Endohm-12 chamber and a volt-ohm-meter. Cellular nanocarrier uptake was analyzed by laser scanning microscopy. Inflammatory responses were determined by monitoring pro-inflammatory cytokines using real-time PCR and ELISA. Results CMS nanocarrier adhered to mucosal tissues within 5 min in an in vitro model and in ex vivo porcine tissues. The CMS nanocarrier exhibited no cytotoxic effects and induced no inflammatory responses. Furthermore, the physical barrier expressed by the TEER remained unaffected by the nanocarrier. Conclusions CMS 10-E-15-350 adhered to the oral mucosa and adhesion increased over time which is a prerequisite for an efficient drug release. Since TEER is unaffected, CMS nanocarrier may enter the oral mucosa transcellularly. Clinical relevance Nanocarrier technology is a novel and innovative approach for efficient topical drug delivery at the oral mucosa.
Wiedemannia (Eucelidia) zetterstedti Fallen
Creators: name: Kustov, Semen
name: Zherebilo, Danil
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Wiedemannia
Wiedemannia zetterstedti

description: Wiedemannia (Eucelidia) zetterstedti (Fallén)
(Fig. 17)
Empis zetterstedti Fallén, 1826: 7.
Material examined. RUSSIA: Krasnodarskiy Territory, env. Oktyabrskiy (2), 29.v.2013, S.Yu.Kustov, V.V. Gladun (2 ♂, 8 ♀); env. Betta (1), 12.vi.2013, V.V. Gladun (3 ♂, 1 ♀); Nature Reserve “Kamyshanova Polyana” (5), 24.vi.2013, S. Kustov (12 ♂, 16 ♀). GEORGIA: Mingrelia, env. Doberazeni (28), 2.v.2014, D. Zherebilo (25 ♂, 20 ♀); Mingrelia, ridge Ofitsari (30), 4.v.2014, D. Zherebilo (7 ♂, 8 ♀); same data, 6.v.2014, D. Zherebilo (31 ♂, 18 ♀); env. Chinkadziebi (25), 6.iv.2015, A.V. Zherebilo (2 ♂); env. Zedachukhuneti (27), 7.iv.2015, A.V. Zherebilo (1 ♂); env. Chaisubani (26), 8.iv.2015, A.V. Zherebilo (3 ♂, 1 ♀); env. Zedakinchha (34), 9.iv.2015, A.V. Zherebilo (1 ♂, 1 ♀); env. Opitara (35), 10.iv.2015, A.V. Zherebilo (3 ♂, 2 ♀); env. Chkumi (36), 11.iv.2015, A.V. Zherebilo (1 ♂); env. Namohvani (37), 15.iv.2015, A.V. Zherebilo (2 ♂, 1 ♀); env. Mukhuri (42), 17.iv.2015, A.V. Zherebilo (1 ♀). ABKHAZIA: River Pshitsa (9), 11.vii.2013, D. Zherebilo (3 ♂, 2 ♀); env. Sukhum (18), 27.vi.2013, D. Zherebilo (12 ♂).
Diagnosis. Wiedemannia (Eucelidia) zetterstedti differs by the completely olive-brown scutum, minute acrostichals extending to second pair of dorsocentrals, 5 pairs of dorsocentrals without intermediate setae interspersed among primary setae, fore femur with 2–3 strong bristles at the tip, fore coxae with 1–3 erect projecting setae, longer than surrounding setae and longer than width of coxa; clasping cercus bilobed, mittenshaped.
Distribution. PALAEARCTIC: Europe: Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyclades Is., Cyprus, Czech Republic, European Turkey, Finland, Germany, Greek mainland, Hungary, Italian mainland, Lithuania, Montenegro, North Aegean Is., Poland, Slovakia, Slovenia, Sweden, Switzerland, The Netherlands; Caucasus: Russia (Krasnodarsky Territory), Georgia, Abkhazia; Asia: Turkey (Bolu: Yedigöller National Park).
Remarks. This species was noted by Joost (1981) from the Sochi River (Russia, Krasnodarskiy Territory), but in the Catalogue of Palaearctic Diptera it was mistakenly indicated from the Georgian territory. Therefore W. (E.) zetterstedti is noted from the territories of Georgia and Abkhazia for the first time. This common species is known from mountain rivers of the Caucasus from elevations between 288–2100 m a.s.l. and is active from April to July.
description: Published as part of Kustov, Semen & Zherebilo, Danil, 2015, New data on the genus Wiedemannia Zetterstedt (Diptera: Empididae) from the Caucasus with description of four new species, pp. 351-369 in Zootaxa 4032 (4) on pages 366-367, DOI: 10.11646/zootaxa.4032.4.1, http://zenodo.org/record/243485
A Snap Shot Of Wwi In 140 Signs One Year On
Creators: name: Project Team, World War I Centenary
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Article contributed to the 'World War I Centenary: Continuations and Beginnings' project.The 'World War I Centenary: Continuations and Beginnings' project ran with contributions from 2012 to 2020. It was an open-access online platform offering free-to-use materials under a Creative Commons Attribution Non-Commercial Sharealike Licence. The project aimed to represent future directions in teaching First World War Studies, challenge existing misconceptions about the conflict, and reappraise the War in its social, cultural, historical, and political contexts. Contributions came from leading academic and non-academic experts, as well as student ambassadors, and include scholarly articles, short talks, lectures, ebooks, innovative computer models, and interactive maps. Funded by the JISC WW1 Open Educational Resources Programme and supported by the JISC 'Statement of Intent', this resource was a collaboration between the University of Oxford teams behind the First World War Poetry Digital Archive, the Great War Archive, and various other educational initiatives. The project's interdisciplinary approach and diverse materials aimed to bring the events, people, and places of World War I into sharp relief for educational and research purposes.
Echthroplexis Forster 1856
Creators: name: Zuparko, Robert L.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Encyrtidae
Echthroplexis

description: Echthroplexis Förster 1856
Hosts. Neuroptera: Hemerobiidae
planiformis (Howard 1895a: 611) (Bothriothorax)
Type. USNM
Distribution. N (Alameda, Alpine, Contra Costa, Kern, Los Angeles, Marin, Placer, Orange, Riverside, San Bernardino, San Joaquin, San Mateo, Santa Barbara, Shasta, Siskiyou, Solano, Stanislaus, Tulare)
Host/habitat. Hemerobius pacificus
Remarks. There is a host record of a? Sympherobius species (UCRC).
description: Published as part of Zuparko, Robert L., 2015, Annotated Checklist of California Encyrtidae (Hymenoptera), pp. 1-126 in Zootaxa 4017 (1) on page 27, DOI: 10.11646/zootaxa.4017.1.1, http://zenodo.org/record/245475
Additional file 1 of Same-session dual chromophore riboflavin/UV-A and rose bengal/green light PACK-CXL in Acanthamoeba keratitis: a case report
Creators: name: Hafezi, Farhad
name: Messerli, Jürg
name: Torres-Netto, Emilio A.
name: Lu, Nan-Ji
name: Aydemir, M. Enes
name: Hafezi, Nikki L.
name: Hillen, Mark
Publisher: name: figshare
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Supplementary Material 1.
Effects of Photopatterning Conditions on Azimuthal Surface Anchoring Strength
Creators: name: Haputhanthrige, Nilanthi P.
name: Rajabi, Mojtaba
name: Lavrentovich, Oleg D.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Spatially varying alignment of liquid crystals is essential for research and applications. One widely used method is based on the photopatterning of thin layers of azo-dye molecules, such as Brilliant Yellow (BY), that serve as an aligning substrate for a liquid crystal. In this study, we examine how photopatterning conditions, such as BY layer thickness (b), light intensity (I), irradiation dose, and age affect the alignment quality and the strength of the azimuthal surface anchoring. The azimuthal surface anchoring coefficient, W, is determined by analyzing the splitting of integer disclinations into half-integer disclinations at pre patterned substrates. The strongest anchoring is achieved for b in the range of 5-8 nm. W increases with the dose, and within the same dose, W increases with I. Aging of a non-irradiated BY coating above 15 days reduces W. Our study also demonstrates that sealed photopatterned cells filled with a conventional nematic preserve their alignment quality for up to four weeks, after which time W decreases. This work suggests the optimization pathways for photoalignment of nematic liquid crystals.
description: 24 Pages, 7 Figures
Ochthebius fausti Sharp 1887
Creators: name: PROKIN, Alexander A.
name: LITOVKIN, Stanislav V.
name: JÄCH, Manfred A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius fausti

description: Ochthebius (s.str.) fausti Sharp, 1887
In Russia this species was known only from the type locality in Orenburg Oblast’ (ST) (Jäch 1991).
Russia (ST): 50°57'06.1"N, 54°16'22.1"E, 80 m, Orenburg Oblast’, Sol‘-Iletsk District, 5.5 km SE Novoiletsk, Ilek River, 22–24 May 2012, leg. S. Litovkin, 2 ex. (SLC).
description: Published as part of PROKIN, Alexander A., LITOVKIN, Stanislav V. & JÄCH, Manfred A., 2015, New records of Hydraenidae and Elmidae (Coleoptera) from Russia and adjacent countries, pp. 99-110 in Fragmenta Faunistica 58 (2) on page 105, DOI: 10.3161/00159301FF2015.58.2.099, http://zenodo.org/record/6251830
Additional file 1 of Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum
Creators: name: Zhi, Yan
name: Mei, Chen
name: Liu, Zhenyi
name: Liu, Ying
name: Wang, Hongjun
Publisher: name: figshare
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1. Strains used in this study.
A Soldier Novelists Reaction
Creators: name: Project Team, World War I Centenary
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Article contributed to the 'World War I Centenary: Continuations and Beginnings' project.The 'World War I Centenary: Continuations and Beginnings' project ran with contributions from 2012 to 2020. It was an open-access online platform offering free-to-use materials under a Creative Commons Attribution Non-Commercial Sharealike Licence. The project aimed to represent future directions in teaching First World War Studies, challenge existing misconceptions about the conflict, and reappraise the War in its social, cultural, historical, and political contexts. Contributions came from leading academic and non-academic experts, as well as student ambassadors, and include scholarly articles, short talks, lectures, ebooks, innovative computer models, and interactive maps. Funded by the JISC WW1 Open Educational Resources Programme and supported by the JISC 'Statement of Intent', this resource was a collaboration between the University of Oxford teams behind the First World War Poetry Digital Archive, the Great War Archive, and various other educational initiatives. The project's interdisciplinary approach and diverse materials aimed to bring the events, people, and places of World War I into sharp relief for educational and research purposes.
title: In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens
Creators: name: Lantier, Isabelle
name: Mallet, Corentin
name: Souci, Laurent
name: Larcher, Thibaut
name: Conradie, Andelé M.
name: Courvoisier, Katia
name: Trapp, Sascha
name: Pasdeloup, David
name: Kaufer, Benedikt B.
name: Denesvre, Caroline
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Chickens
subject: Feathers
subject: Animal wings
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: In vivo bioluminescence imaging facilitates the non-invasive visualization of biological processes in living animals. This system has been used to track virus infections mostly in mice and ferrets; however, until now this approach has not been applied to pathogens in avian species. To visualize the infection of an important avian pathogen, we generated Marek’s disease virus (MDV) recombinants expressing firefly luciferase during lytic replication. Upon characterization of the recombinant viruses in vitro, chickens were infected and the infection visualized in live animals over the course of 14 days. The luminescence signal was consistent with the known spatiotemporal kinetics of infection and the life cycle of MDV, and correlated well with the viral load measured by qPCR. Intriguingly, this in vivo bioimaging approach revealed two novel sites of MDV replication, the beak and the skin of the feet covered in scales. Feet skin infection was confirmed using a complementary fluorescence bioimaging approach with MDV recombinants expressing mRFP or GFP. Infection was detected in the intermediate epidermal layers of the feet skin that was also shown to produce infectious virus, regardless of the animals’ age at and the route of infection. Taken together, this study highlights the value of in vivo whole body bioimaging in avian species by identifying previously overlooked sites of replication and shedding of MDV in the chicken host.
Evidence of epigenetic oncogenesis: a turning point in cancer research
Creators: name: Capp, Jean-Pascal
name: Aliaga, Benoît
name: Pancaldi, Vera
Publisher: name: arXiv
Year: 2024
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: In cancer research, the term epigenetics was used in the 1970s in its modern sense encompassing non-genetic events modifying the chromatin state, mainly to oppose the emerging oncogene paradigm. However, starting from the establishment of this prominent concept, the importance of these epigenetic phenomena in cancer rarely led to questioning the causal role of genetic alterations. Only in the last 10 years, the accumulation of problematic data, better experimental technologies, and some ambitious models pushed the idea that epigenetics could be at least as important as genetics in early oncogenesis. Until this year, a direct demonstration of epigenetic oncogenesis was still lacking. Now Parreno, Cavalli and colleagues, using a refined experimental model in the fruit fly Drosophila melanogaster, enforced the initiation of tumours solely by imposing a transient loss of Polycomb repression, leading to a purely epigenetic oncogenesis phenomenon. Despite a few caveats that we discuss, this pioneering work represents a major breakpoint in cancer research that leads us to consider the theoretical and conceptual implications on oncogenesis and to search for links between this artificial experimental model and naturally occurring processes, while revisiting cancer theories that were previously proposed as alternatives to the oncogene-centered paradigm.
Additional file 8 of Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum
Creators: name: Zhi, Yan
name: Mei, Chen
name: Liu, Zhenyi
name: Liu, Ying
name: Wang, Hongjun
Publisher: name: figshare
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 8: Overview of metabolic pathway alterations and ribosomal protein expression changes in Av. paragallinarum following GR knockout. The diagram depicts a comprehensive map of metabolic processes with enzymes coded by differentially expressed genes (DEGs) following the GR gene disruption. Blue boxes represent enzymes associated with metabolic pathways that were not detected; green boxes indicate enzymes that were detected but did not show significant expression changes; red boxes signify downregulated enzymes, and purple boxes signify upregulated enzymes. In addition, upregulation in ribosomal proteins is denoted by pink shading in the ribosomal structure to the right. The metabolic pathways and corresponding enzymes are organized around the TCA cycle at the center, branching out to include amino acid metabolism, purine metabolism, and the glutathione cycle, highlighting the interconnectivity and complex response to the oxidative stress induced by the absence of GR.