cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Эпидемия конверсионных расстройств в Жанаозене (западный Казахстан): история развития, диагнозы и прогнозы
Creators: name: Молчанова Елена Сергеевна
name: Назаретян Акоп Погосович
name: Жолдасова Жибек
name: Исмаилов Ербол
name: Карнацкая Лариса Анатольевна
name: Кувшинова Наталия Юрьевна
name: Матвеева Наталья Эммануиловна
name: Толеш Айнеш
Publisher: name: Историческая психология и социология истории
Year: 2016
Subjects: DISSOCIATIVE DISORDER
EPIDEMIC
TRAUMATIC STRESS
COGNITIVE SCHEMES
ДИССОЦИАТИВНОЕ РАССТРОЙСТВО
ЭПИДЕМИЯ
ТРАВМАТИЧЕСКИЙ СТРЕСС
КОГНИТИВНЫЕ СХЕМЫ

description: В статье рассматриваются предыстория и механизмы развития массового диссоциативного расстройства, зарегистрированного в феврале апреле 2015 года в городе Жанаозен (Казахстан), где добывается 8 % всей казахстанской нефти. Изначально это было вахтовое поселение, предназначенное для кратковременного проживания работников нефтяной промышленности. Несмотря на суровый климат и некомфортные условия проживания, благодаря относительно высоким заработкам город стал своего рода центром миграции этнических казахов, проживающих в других странах бывшего Советского Союза. Жесткое деление на своих и чужих, «нефтяников» и «прочих» создавало предпосылки для рекуррентно текущего внутригородского конфликта, на фоне которого развернулись трагические события декабря 2011 года, когда забастовка нефтяников закончилась кровавым побоищем. Высокий уровень травматического стресса, синдром жертвы, вторичная выгода от травматизации и относительная изоляция «пришлых» создали благоприятный фон для вспышки массового диссоциативного расстройства, которое позже в сознании горожан ассоциировалось с массовой вакцинацией против кори. Авторы статьи описывают историю болезни города в промежутке от мая 2011 года до апреля 2015 года и рассматривают основные кризисы, перенесенные его жителями.
description: The article considers prehistory and mechanisms of development of mass dissociative disorders registered between February and April 2015 in Janaozen, Kazakhstan, where 8 % of all Kazakh oil has been extracted since the 1950s. From the very beginning this town was the short-term settlement for the workers of oil industry. Despite harsh climate and uncomfortable living conditions on the one hand, and due to relatively high salaries on the other hand, the city became a “Mecca” for ethnic Kazakhs ( oralmans ), who migrated from other countries of the former USSR. The strict division between “ours” and “ oralmans ” created a variety of predispositions for the existence of a recurrent intra-city conflict, which served as a background for the tragic events of December, 2011. The strike of oil workers ended in a bloody carnage with long-lasting consequences. The high level of traumatic stress, the victim syndrome, secondary gain of traumatization, and relative isolation of oralmans created plausible conditions for explosion of mass dissociative disorders, which in social consciousness was associated with measles vaccination. The authors describe the medical history of the town in the period from May, 2011 to April, 2015. The main population crises are considered in the article.
Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE
Creators: name: Zhang, Yuelu
name: Huang, Jiancheng
name: Liang, Yu
name: Huang, Jiaqiu
name: Fu, Yuhua
name: Chen, Ningxie
name: Lu, Boxun
name: Zhao, Chen
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences

description: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly, and there is currently no clinical treatment targeting the primary impairment of AMD. The earliest clinical hallmark of AMD is drusen, which are yellowish spots mainly composed of lipid droplets (LDs) accumulated under the retinal pigment epithelium (RPE). However, the potential pathogenic role of this excessive LD accumulation in AMD is yet to be determined, partially due to a lack of chemical tools to manipulate LDs specifically. Here, we employed our recently developed Lipid Droplets·AuTophagy Tethering Compounds (LD∙ATTECs) to degrade LDs and to evaluate its consequence on the AMD-like phenotypes in apoe−/− (apolipoprotein E; B6/JGpt-Apoeem1Cd82/Gpt) mouse model. apoe−/− mice fed with high-fat diet (apoe−/−-HFD) exhibited excessive LD accumulation in the retina, particularly with AMD-like phenotypes including RPE degeneration, Bruch’s membrane (BrM) thickening, drusen-like deposits, and photoreceptor dysfunction. LD·ATTEC treatment significantly cleared LDs in RPE/choroidal tissues without perturbing lipid synthesis-related proteins and rescued RPE degeneration and photoreceptor dysfunction in apoe−/−-HFD mice. This observation implied a causal relationship between LD accumulation and AMD-relevant phenotypes. Mechanically, the apoe−/−-HFD mice exhibited elevated oxidative stress and inflammatory signals, both of which were mitigated by the LD·ATTEC treatment. Collectively, this study demonstrated that LD accumulation was a trigger for the process of AMD and provided entry points for the treatment of the initial insult of AMD by degrading LDs. Abbreviations: AMD: age-related macular degeneration; APOE: apolipoprotein E; ATTECs: autophagy-tethering compounds; BODIPY: boron-dipyrromethene; BrM: Bruch’s membrane; ERG: electroretinogram; HFD: high-fat diet; LD·ATTECs: Lipid Droplets·AuTophagy Tethering Compounds; LDs: lipid droplets; OA: oleic acid; OPL: outer plexiform layer; ROS: reactive oxygen species; RPE: retinal pigment epithelium
title: Geropogon hybridus (L.) Sch.Bip. (Asteraceae) exhibits micro-geographic genetic divergence at ecological range limits along a steep precipitation gradient
Creators: name: Müller, Christina M.
name: Schulz, Benjamin
name: Lauterbach, Daniel
name: Ristow, Michael
name: Wissemann, Volker
name: Gemeinholzer, Birgit
Publisher: name: Universität Potsdam
Year: 2020

description: We analyzed the population genetic pattern of 12 fragmented Geropogon hybridus ecological range edge populations in Israel along a steep precipitation gradient. In the investigation area (45 x 20 km(2)), the annual mean precipitation changes rapidly from 450 mm in the north (Mediterranean-influenced climate zone) to 300 mm in the south (semiarid climate zone) without significant temperature changes. Our analysis (91 individuals, 12 populations, 123 polymorphic loci) revealed strongly structured populations (AMOVA I broken vertical bar(ST) = 0.35; P < 0.001); however, differentiation did not change gradually toward range edge. IBD was significant (Mantel test r = 0.81; P = 0.001) and derived from sharply divided groups between the northernmost populations and the others further south, due to dispersal or environmental limitations. This was corroborated by the PCA and STRUCTURE analyses. IBD and IBE were significant despite the micro-geographic scale of the study area, which indicates that reduced precipitation toward range edge leads to population genetic divergence. However, this pattern diminished when the hypothesized gene flow barrier was taken into account. Applying the spatial analysis method revealed 11 outlier loci that were correlated to annual precipitation and, moreover, were indicative for putative precipitation-related adaptation (BAYESCAN, MCHEZA). The results suggest that even on micro-geographic scales, environmental factors play prominent roles in population divergence, genetic drift, and directional selection. The pattern is typical for strong environmental gradients, e.g., at species range edges and ecological limits, and if gene flow barriers and mosaic-like structures of fragmented habitats hamper dispersal.
Molecular structures of the open-shell IPR isomers of fullerene C90
Creators: name: Ayrat R. Khamatgalimov
name: Kovalenko, Valeri I.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Fifteen open-shell isomers off the forty six IPR isomers of fullerene C90 were found and investigated: 5 (Cs), 7 (C1), 9 (C1), 10 (Cs), 11 (C1), 20 (C1), 21 (C1), 22 (C1), 23 (C2), 24 (C1), 25 (C2v), 41 (C2), 42 (C2), 43 (C2), and 44 (C2). According to developed by us approach the positions of single, double, and delocalized π-bonds in the molecules of these isomers are shown for the first time. The obtained results of electronic and geometrical structures are fully supported by DFT method with the B3LYP functional at the 6-31G and 6-31G* levels. Molecules of these open-shell isomers contain different radical substructures (mainly the phenalenyl-radical substructures), they should be unstable and could not be obtained as empty molecules. Nevertheless, there is a possibility of obtaining them in polymeric forms or as endohedral or exohedral derivatives.
title: A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis
Creators: name: Shirzadian-Khorramabad, Reza
name: Jing, Hai-Chun
name: Everts, Gerja E.
name: Schippers, Jos H. M.
name: Hille, Jacques
name: Dijkwel, Paul P.
Publisher: name: Universität Potsdam
Year: 2020

description: Background: Cysteine is a component in organic compounds including glutathione that have been implicated in the adaptation of plants to stresses. O-acetylserine (thiol) lyase (OAS-TL) catalyses the final step of cysteine biosynthesis. OAS-TL enzyme isoforms are localised in the cytoplasm, the plastids and mitochondria but the contribution of individual OAS-TL isoforms to plant sulphur metabolism has not yet been fully clarified. Results: The seedling lethal phenotype of the Arabidopsis onset of leaf death3-1 (old3-1) mutant is due to a point mutation in the OAS-A1 gene, encoding the cytosolic OAS-TL. The mutation causes a single amino acid substitution from Gly(162) to Glu(162), abolishing old3-1 OAS-TL activity in vitro. The old3-1 mutation segregates as a monogenic semidominant trait when backcrossed to its wild type accession Landsberg erecta (Ler-0) and the Di-2 accession. Consistent with its semi-dominant behaviour, wild type Ler-0 plants transformed with the mutated old3-1 gene, displayed the early leaf death phenotype. However, the old3-1 mutation segregates in an 11: 4: 1 (wild type: semi-dominant: mutant) ratio when backcrossed to the Colombia-0 and Wassilewskija accessions. Thus, the early leaf death phenotype depends on two semi-dominant loci. The second locus that determines the old3-1 early leaf death phenotype is referred to as odd-ler (for old3 determinant in the Ler accession) and is located on chromosome 3. The early leaf death phenotype is temperature dependent and is associated with increased expression of defence-response and oxidative-stress marker genes. Independent of the presence of the odd-ler gene, OAS-A1 is involved in maintaining sulphur and thiol levels and is required for resistance against cadmium stress. Conclusions: The cytosolic OAS-TL is involved in maintaining organic sulphur levels. The old3-1 mutation causes genome-dependent and independent phenotypes and uncovers a novel function for the mutated OAS-TL in cell death regulation.
Protocol – A Systematic Scoping Review of the Empirical Literature on Insider Cyber Threats
Creators: name: Moneva, Asier
name: Leukfeldt, Eric Rutger
name: Trinidad, Alexander
Publisher: name: Open Science Framework
Year: 2021

description: A protocol for a systematic review on the empirical literature on insider cyber threats that adheres to the PRISMA guidelines for Scoping Reviews.
title: Editorial: energy, resources and the environment
title: interdisciplinary answers to approach the sustainable energy and resources conundrum
titleType: Subtitle
Creators: name: Martens, Sonja
name: Juhlin, Christopher
name: Bruckman, Viktor J.
name: Mitchell, Kristen
name: Griffiths, Luke
name: Kühn, Michael
Publisher: name: Universität Potsdam
Year: 2020

description: Every year, the European Geosciences Union (EGU) brings together experts from all over the world at its General Assembly, covering all disciplines of the Earth, planetary and space sciences. The EGU Division on Energy, Resources and the Environment (ERE) is concerned with one of the humankind's most challenging goals – providing affordable, reliable and sustainable energy and other georesources. A collection of contributions from the ERE Division at the EGU General Assembly 2018 is assembled within the present special issue in Advances in Geosciences.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 834
TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ
Creators: name: Chae, Chang Woo
name: Yoon, Jee Hyeon
name: Lim, Jae Ryong
name: Park, Ji Yong
name: Cho, Ji Hyeon
name: Jung, Young Hyun
name: Choi, Gee Euhn
name: Lee, Hyun Jik
name: Han, Ho Jae
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Lysosomal dysfunction is a pathogenic link that may explain the causal relationship between diabetes and Alzheimer disease; however, there is no information about the regulation of hyperglycemia in neuronal lysophagy modulating lysosomal function. We examined the effect and related mechanisms of action of high glucose on lysophagy impairment and subsequent Aβ accumulation in human induced pluripotent stem cell (hiPSC)-derived neurons, mouse hippocampal neurons, and streptozotocin (STZ)-induced diabetic mice. High-glucose induced neuronal lysosomal dysfunction through reactive oxygen species-mediated lysosomal membrane permeabilization and lysophagy impairment. Among lysophagy-related factors, the expression of TRIM16 (tripartite motif containing 16) was reduced in high-glucose-treated neuronal cells and the diabetic hippocampus through MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1)-mediated inhibition of TFEB (transcription factor EB) activity. TRIM16 overexpression recovered lysophagy through the recruitment of MAP1LC3/LC3 (microtubule associated protein 1 light chain 3), SQSTM1/p62, and ubiquitin to damaged lysosomes, which inhibited the high-glucose-induced accumulation of Aβ and p-MAPT/tau. In the diabetic mice model, TFEB enhancer recovered lysophagy in the hippocampus, resulting in the amelioration of cognitive impairment. In conclusion, TRIM16-mediated lysophagy is a promising candidate for the inhibition of diabetes-associated Alzheimer disease pathogenesis. Aβ: amyloid β; AD: Alzheimer disease; AMPK: 5’ adenosine monophosphate-activated protein kinase; CTSB: cathepsin B; CTSD: cathepsin D; DM: diabetes mellitus; ESCRT: endosomal sorting complex required for transport; FBXO27: F-box protein 27; iPSC-NDs: induced pluripotent stem cell-derived neuronal differentiated cells; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile alpha motif containing 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; p-MAPT/tau: phosphorylated microtubule associated protein tau; ROS: reactive oxygen species; STZ: streptozotocin; TFE3: transcription factor E3; TFEB: transcription factor EB; TRIM16: tripartite motif containing 16; UBE2QL1: ubiquitin conjugating enzyme E2 Q family like 1; VCP: valosin containing protein.
title: The BY-COVID Guide to using WorkflowHub
Creators: name: Goble, Carole
name: Bacall, Finn
name: Soiland-Reyes, Stian
Publisher: name: WorkflowHub
Year: 2024

description: The BY-COVID project is producing workflows. We need to register those workflows in WorkflowHub:

1. To give visibility to the workflows created by the project and by the different networks and communities within the project
1. To give visibility to the workflows used by project that were created 
1. To share workflows across the project, within project networks and externally
1. To credit and cite the people making the workflows and the networks to which they belong
1. To track the versions of workflows as they are produced, and
1. To retain the workflows for post-project use by the networks
title: „Was ist Migration?“
title: Risiken eines essentialistischen Migrationsbegriffs in der Erwachsenenbildung
titleType: Subtitle
Creators: name: Ebner von Eschenbach, Malte
Publisher: name: Universität Potsdam
Year: 2020

description: Auch wenn die Appelle, die Bedeutung von Migration für Erwachsenenbildung deutlicher wahrzunehmen, unüberhörbar sind, bleiben sie bezüglich kategorialer Arbeit bemerkenswert wenig beachtet. Grundlagentheoretisch motivierte Arbeit am Begriff „Migration“ ist in der Erwachsenenbildung noch lange nicht hinreichend ausgeschöpft. Auch wenn sich einzelne Studien mit ihm auseinandersetzen, besteht dennoch der Eindruck, dass kategoriale Klärungsversuche singulär bleiben. Die nicht einfache Aufgabe, den Begriff Migration vor seiner kategorialen Stilllegung zu bewahren, bleibt eine ernsthafte Herausforderung für erwachsenenpädagogische Migrationsforschung, sofern sie daran interessiert ist, die Risiken eines bisher essentialistischen Kurses ernsthaft ins Visier zu nehmen.
description: While the calls to take more notice of the significance of migration for adult education are loud and clear, notably little attention is paid to them with regard to work on categories. In adult education, fundamental theoretical work on definitions of “migration” is still far from complete. Even though individual studies deal with the term, it seems that attempts to clarify categories remain scarce. If adult education research on migration has a genuine interest in examining the risks of the hitherto essentialist course, the none-too simple task of preserving the term “migration” from categorial closedown remains a serious challenge.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 605
Molecular Structures of the Open-shell IPR Isomers of Fullerene C90
Creators: name: Ayrat R. Khamatgalimov
name: Kovalenko, Valeri I.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Fifteen open-shell isomers off the forty six IPR isomers of fullerene C90 were found and investigated: 5 (Cs), 7 (C1), 9 (C1), 10 (Cs), 11 (C1), 20 (C1), 21 (C1), 22 (C1), 23 (C2), 24 (C1), 25 (C2v), 41 (C2), 42 (C2), 43 (C2), and 44 (C2). According to developed by us approach the positions of single, double, and delocalized π-bonds in the molecules of these isomers are shown for the first time. The obtained results of electronic and geometrical structures are fully supported by DFT method with the B3LYP functional at the 6–31G and 6–31G* levels. Molecules of these open-shell isomers contain different radical substructures (mainly the phenalenyl-radical substructures), they should be unstable and could not be obtained as empty molecules. Nevertheless, there is a possibility of obtaining them in polymeric forms or as endohedral or exohedral derivatives.
Protocol: A Scoping Review of the Empirical Literature on Insider Cyber Threats
Creators: name: Moneva, Asier
name: Trinidad, Alexander
name: Leukfeldt, Eric Rutger
Publisher: name: OSF Registries
Year: 2021

description: A protocol for a systematic review on the empirical literature on insider cyber threats that adheres to the PRISMA guidelines for Scoping Reviews.
Flavonoids and biological activities of various extracts from Rosa sempervirens leaves
Creators: name: Bitis, Leyla
name: Sen, Ali
name: Ozsoy, Nurten
name: Birteksoz-Tan, Seher
name: Sukran Kultur
name: Gulay Melikoglu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Rosa sempervirens L. (Rosaceae) growing wildly in Turkey is used in folk medicine for various indications. Here, we report the isolation of four flavonoids and determination of the total phenolic and flavonoid contents and the antimicrobial and antioxidant activities of various extracts from R. sempervirens leaves. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). The total phenolic and flavonoid contents were determined using the Folin–Ciocalteu and AlCl3 methods, respectively. The antimicrobial activity was evaluated by the broth microdilution method against seven microbial species. The ethyl acetate extract (E) had significant antioxidant activity with half maximal inhibitory concentration (IC50) values of 3.96 in the DPPH and 2.92 µg/mL in the ABTS assay. The total phenolic (203.8 mg gallic acid equivalents/g extract) and total flavonoid (95.81 mg catechin equivalents/g extract) contents of the E extract were significantly higher as compared to other extracts. The E extract exhibited strong antimicrobial activity against Candida albicans with a minimum inhibitory concentration of 39 μg/mL. Quercetin 3-xyloside, quercitrin and hyperoside were isolated from the E extract and quercetin, from the chloroform extract, and quercetin and hyperoside were identified for the first time in this species. Quercitrin was found to be a major compound in the E extract. Antimicrobial activity of R. sempervirens was also reported for the first time. These results indicate that the E extract has significant antioxidant and antimicrobial activity, probably due to flavonoids as well as other phenolic compounds in the E extract, acting individually or in combination.
title: Limitations of turbidity process probes and formazine as their calibration standard
Creators: name: Münzberg, Marvin
name: Hass, Roland
name: Khanh, Ninh Dinh Duc
name: Reich, Oliver
Publisher: name: Universität Potsdam
Year: 2020

description: Turbidity measurements are frequently implemented for the monitoring of heterogeneous chemical, physical, or biotechnological processes. However, for quantitative measurements, turbidity probes need calibration, as is requested and regulated by the ISO 7027:1999. Accordingly, a formazine suspension has to be produced. Despite this regulatory demand, no scientific publication on the stability and reproducibility of this polymerization process is available. In addition, no characterization of the optical properties of this calibration material with other optical methods had been achieved so far. Thus, in this contribution, process conditions such as temperature and concentration have been systematically investigated by turbidity probe measurements and Photon Density Wave (PDW) spectroscopy, revealing an influence on the temporal formazine formation onset. In contrast, different reaction temperatures do not lead to different scattering properties for the final formazine suspensions, but give an access to the activation energy for this condensation reaction. Based on PDW spectroscopy data, the synthesis of formazine is reproducible. However, very strong influences of the ambient conditions on the measurements of the turbidity probe have been observed, limiting its applicability. The restrictions of the turbidity probe with respect to scatterer concentration are examined on the basis of formazine and polystyrene suspensions. Compared to PDW spectroscopy data, signal saturation is observed at already low reduced scattering coefficients.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 831
title: Live cell flattening
title: traditional and novel approaches
titleType: Subtitle
Creators: name: Westendorf, Christian
name: Bae, Albert J.
name: Erlenkamper, Christoph
name: Galland, Edouard
name: Franck, Carl
name: Bodenschatz, Eberhard
name: Beta, Carsten
Publisher: name: Universität Potsdam
Year: 2020

description: Eukaryotic cell flattening is valuable for improving microscopic observations, ranging from bright field (BF) to total internal reflection fluorescence (TIRF) microscopy. Fundamental processes, such as mitosis and in vivo actin polymerization, have been investigated using these techniques. Here, we review the well known agar overlayer protocol and the oil overlay method. In addition, we present more elaborate microfluidics-based techniques that provide us with a greater level of control. We demonstrate these techniques on the social amoebae Dictyostelium discoideum, comparing the advantages and disadvantages of each method.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 835
title: Portal alumni
Creators: name: Pohlenz, Philipp
name: Grindel, Elisabeth
name: Dahlmann, Olaf
name: Harder, Benjamin
name: Obst, Barbara
name: Steinbach, Sylvia
name: Schmahl, Katrin
name: Müller, Katja
name: Steible, Stefanie
name: Isakowitz, Marcel
name: Lambrecht, Alyssa
name: Stabsstelle Studierendenmarketing/Alumniprogramm Im Auftrag Der Präsidentin Der Universität Potsdam
Publisher: name: Universität Potsdam
Year: 2020

description: Begonnen hat es um 1900 mit Qualitätskontrolle, später folgte Qualitätsprüfung und seit Mitte der 90er Jahre hat das Thema Qualitätsmanagement Einzug gehalten in alle Bereiche von Politik und Gesellschaft. Im Gesundheitswesen, der Justiz und auch an vielen Hochschulen wurden spezielle Stellen eingerichtet, die sich gezielt mit der Umsetzung von Qualitätsentwicklung oder Qualitätsmanagement befassen. Das übergeordnete Ziel bei Einführung eines Qualitätsmanagements ist es, die Wettbewerbsfähigkeit der Organisation sowie auch die Zufriedenheit der Mitglieder der Institutionen und weiterer Stakeholder zu steigern, indem die Qualität der Tätigkeiten und der jeweiligen Rahmenbedingungen erhalten und optimiert wird. Mit der bewussten Entscheidung zur Qualitätssicherung und -entwicklung beginnt ein fortlaufender Prozess, der stetig intensiv begleitet werden muss. Qualitätsmanagement wirkt nachhaltig, in dem durch die Schaffung regelmäßiger und systematischer Strukturen und Prozesse auch zukünftig den beteiligten Personen ein optimales Handeln entsprechend der dann geltenden Bedingungen ermöglicht wird. Portal alumni widmet sich in seinem zehnten Heft diesem Thema und hat Absolventen der Universität Potsdam nach ihrem Tätigkeitsfeld im Qualitätsmanagement und den entsprechenden Erfolgen befragt. Dabei zeigt sich, dass Ehemalige Einsatzbereiche in Wirtschaft und Unternehmen aber auch in Sport, Bildung oder Hochschulen gefunden haben. Daneben berichten wir in diesem Heft von einem Projekt des Career Service, dem Schnupperjobben, und auch die Berichte über die Geschehnisse an Ihrer Alma mater kommen nicht zu kurz.
description: Portal alumni : das Ehemaligen-Magazin der Universität Potsdam, 10/2013
Agariste of Sicyon and the contest for Greece
Creators: name: Harrison, Thomas
Publisher: name: Syllogos - Herodotus Journal
Year: 2024

description: This paper re-examines Herodotus’ account of the marriage contest held by Cleisthenes, tyrant of Sicyon, for the hand of his daughter Agariste. It focuses less on the episode’s historicity or its literary antecedents than on the story’s position in the Histories more widely, and the background knowledge of leading Athenian families that might be taken for granted by Herodotus in his readers/audience. The paper suggests a cynical perspective on the historian’s part towards both the development of Athenian democracy and aristocratic sporting competition, and argues for the importance of patterns of prefigurement across the Histories as a whole.
description: Syllogos - Herodotus Journal, Vol. 3 (2024)
FORMATION AND DESCRIPTION OF ECONOMIC RESOURCES IN THE SERVICE FIELD
Creators: name: Erkinov, Behbud
Publisher: name: Zenodo
Year: 2024

description: In this article, it is explained scientifically and theoretically that the service sector is expanding in the world and that the efficiency of service enterprises in our country is considered more efficient than production, because the initial activity in the service sector requires less investment and the turnover rate of financial funds is high.
title: The Feasibility and Effectiveness of a New Practical Multidisciplinary Treatment for Low-Back Pain
title: A Randomized Controlled Trial
titleType: Subtitle
Creators: name: Wippert, Pia-Maria
name: Drießlein, David
name: Beck, Heidrun
name: Schneider, Christian
name: Puschmann, Anne-Katrin
name: Banzer, Winfried
name: Schiltenwolf, Marcus
Publisher: name: Universität Potsdam
Year: 2020

description: Low-back pain is a major health problem exacerbated by the fact that most treatments are not suitable for self-management in everyday life. Particularly, interdisciplinary programs consist of intensive therapy lasting several weeks. Additionally, therapy components are rarely coordinated regarding reinforcing effects, which would improve complaints in persons with higher pain. This study assesses the effectiveness of a self-management program, firstly for persons suffering from higher pain and secondly compared to regular routines. Study objectives were treated in a single-blind multicenter controlled trial. A total of n = 439 volunteers (age 18–65 years) were randomly assigned to a twelve-week multidisciplinary sensorimotor training (3-weeks-center- and 9-weeks-homebased) or control group. The primary outcome pain (Chronic-Pain-Grade) as well as mental health were assessed by questionnaires at baseline and follow-up (3/6/12/24 weeks, M2-M5). For statistical analysis, multiple linear regression models were used. N = 291 (age 39.7 ± 12.7 years, female = 61.1%, 77% CPG = 1) completed training (M1/M4/M5), showing a significantly stronger reduction of mental health complaints (anxiety, vital exhaustion) in people with higher than those with lower pain in multidisciplinary treatment. Compared to regular routines, the self-management–multidisciplinary treatment led to a clinically relevant reduction of pain–disability and significant mental health improvements. Low-cost exercise programs may provide enormous relief for therapeutic processes, rehabilitation aftercare, and thus, cost savings for the health system
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 840
New fluorescent metal receptors based on 4,4′-carbonyl bis(carbamoylbenzoic) acid analogues with naphthalene fluorophore
Creators: name: Martínez-Quiroz, Marisela
name: Ochoa-Terán, Adrián
name: Aguilar-Martínez, Milagros
name: García-Elías, José
name: Hisila Santacruz Ortega
name: Miranda-Soto, Valentín
name: Pina-Luis, Georgina
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: In this manuscript is described a research related with two ditopic receptors based on 4,4′-carbonyl bis(carbamoylbenzoic) acids bearing a naphthyl (2a) and naphthylmethyl fluorophores (2b), which interact with metal ions. The fluorescence properties of both receptors were influenced by the connectivity with the amide group. The non-spaced receptor 2a presents an electron delocalisation from the amide to the naphthyl group having a broad red-shifted emission band and high quantum yield. The spaced receptor 2b presented a photo-induced electron transfer (PET) process from the amide to the naphthyl group, and a structured emission band is present at the UV region with low quantum yield. The different chemical structure influenced the fluorescent response used to analyse the coordination with metallic ions. The 2a receptor has an ON–OFF response because of the inhibition of the ICT process. The 2b receptor shows an OFF–ON response because of the inhibition of the PET process. Additional analytical studies by 1H-NMR and FTIR demonstrated the strong interaction of the amide and carboxylic functional groups with the metallic ions. Competitive experiments with EDTA showed that a very stable complexes are obtained between metallic ions and the new receptors.
A cross-cultural study on emotion expression and the learning of social norms
Creators: name: Hareli, Shlomo
name: Kafetsios, Konstantinos
name: Hess, Ursula
Publisher: name: Humboldt-Universität zu Berlin
Year: 2015
Subjects: subject: emotion expressions
subject: social signals
subject: normative behavior
subject: 150 Psychologie

description: When we do not know how to correctly behave in a new context, the emotions that people familiar with the context show in response to the behaviors of others, can help us understand what to do or not to do. The present study examined cross-cultural differences in how group emotional expressions (anger, sadness, neutral) can be used to deduce a norm violation in four cultures (Germany, Israel, Greece, and the US), which differ in terms of decoding rules for negative emotions. As expected, in all four countries, anger was a stronger norm violation signal than sadness or neutral expressions. However, angry and sad expressions were perceived as more intense and the relevant norm was learned better in Germany and Israel than in Greece and the US. Participants in Greece were relatively better at using sadness as a sign of a likely norm violation. The results demonstrate both cultural universality and cultural differences in the use of group emotion expressions in norm learning. In terms of cultural differences they underscore that the social signal value of emotional expressions may vary with culture as a function of cultural differences, both in emotion perception, and as a function of a differential use of emotions.
RIPB aspects in part 53 draft rule package
Creators: name: Reckley, William
Publisher: name: F1000 Research Limited
Year: 2024

description: This presentation was given as part of the American Nuclear Society Risk-informed, Performance-based Policy and Procedures Committee (RP3C) Community of Practice (CoP). For more information on the RP3C CoP, please visit https://www.ans.org/standards/rp3c/cop/.



This presentation took place on October 28, 2022.



The presentation video recording can be found online at https://youtu.be/8tnObLILCEw.
Thrombospondin-1 mediates multi-walled carbon nanotube induced impairment of arteriolar dilation
Creators: name: W. Kyle Mandler
name: Nurkiewicz, Timothy R.
name: Porter, Dale W.
name: I. Mark Olfert
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) has been shown to disrupt endothelium-dependent arteriolar dilation in the peripheral microcirculation. The molecular mechanisms behind these arteriolar disruptions have yet to be fully elucidated. The secreted matricellular matrix protein thrombospondin-1 (TSP-1) is capable of moderating arteriolar vasodilation by inhibiting soluble guanylate cyclase activity. We hypothesized that TSP-1 may be a link between nanomaterial exposure and observed peripheral microvascular dysfunction. To test this hypothesis, wild-type C57B6J (WT) and TSP-1 knockout (KO) mice were exposed via lung aspiration to 50 μg MWCNT or a Sham dispersion medium control. Following exposure (24 h), arteriolar characteristics and reactivity were measured in the gluteus maximus muscle using intravital microscopy (IVM) coupled with microiontophoretic delivery of acetylcholine (ACh) or sodium nitroprusside (SNP). In WT mice exposed to MWCNT, skeletal muscle TSP-1 protein increased > fivefold compared to Sham exposed, and exhibited a 39% and 47% decrease in endothelium-dependent and -independent vasodilation, respectively. In contrast, TSP-1 protein was not increased following MWCNT exposure in KO mice and exhibited no loss in dilatory capacity. Microvascular leukocyte–endothelium interactions were measured by assessing leukocyte adhesion and rolling activity in third order venules. The WT + MWCNT group demonstrated 223% higher leukocyte rolling compared to the WT + Sham controls. TSP-1 KO animals exposed to MWCNT showed no differences from the WT + Sham control. These data provide evidence that TSP-1 is likely a central mediator of the systemic microvascular dysfunction that follows pulmonary MWCNT exposure.
title: A Question of Jurisdiction: Art. 267 TFEU Preliminary References of a CFSP Nature
Creators: name: Butler, Graham
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2017
Subjects: subject: Court of Justice of the European Union
subject: Common Foreign and Security Policy
subject: preliminary reference
subject: restrictive measures
subject: sanctions
subject: jurisdiction

description: European Papers - A Journal on Law and Integration, 2017 2(1), 201-208
description: European Forum Insight of 1 April 2017
description: I. Ambiguity of the Treaties: jurisdiction. - II. Judgment. - III. Analysis.
description: Can the Court of Justice of the European Union assert jurisdiction and provide a national court with an interpretation of Union law in a case referred to it from a national court under an Art. 267 TFEU preliminary reference, when the subject matter is in regard to the Common Foreign and Security Policy (CFSP)? This was one of a number of questions referred to the Court of Justice from the High Court of England and Wales in Rosneft (judgment of 28 March 2017, case C-72/15). In March 2017, the Court of Justice meeting in a Grand Chamber formation, answered this jurisdictional question in the affirmative. Given the significance of this judgment for the law of CFSP, and the Opinion of the Advocate General in 2016, this judgment was hotly anticipated given its implications for the "specific rules and procedures" that are applicable to the law of CFSP. As the Court of Justice continues in a line of case law to clarify its jurisdiction in CFSP, it is ultimately a question of constitutional importance for the EU's external relations.
title: Историко-культурное наследие Псковского края
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2025

description: Представленная в учебном пособии информация позволяет сформировать общее представление об основных памятниках культуры Псковского края. Описана история Псковского края, начиная с первых поселений и до ХХ века. Учебное пособие предназначено для студентов неисторических факультетов, изучающих дисциплину «Историко-культурное наследие Псковского края». Также может быть использовано школьными учителями при разработке уроков по предмету «История Псковского края» и факультативных занятий, может быть любопытна всем интересующимся историей Псковского края.
The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism
Creators: name: Delorme-Axford, Elizabeth
name: Wen, Xin
name: Klionsky, Daniel J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Mental Health
subject: Computational Biology

description: Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberrant cellular autophagy contributes to the pathogenesis of human diseases such as cancer, neurodegeneration, and cardiovascular, metabolic and lysosomal storage disorders. Despite decades of research, there remain unanswered questions as to how autophagy modulates cellular metabolism, and, conversely, how cellular metabolism affects autophagy activity. Here, we have identified the yeast metabolic transcription factor Stb5 as a negative regulator of autophagy. Chromosomal deletion of STB5 in the yeast Saccharomyces cerevisiae enhances autophagy. Loss of Stb5 results in the upregulation of select autophagy-related (ATG) transcripts under nutrient-replete conditions; however, the Stb5-mediated impact on autophagy occurs primarily through its effect on genes involved in NADPH production and the pentose phosphate pathway. This work provides insight into the intersection of Stb5 as a transcription factor that regulates both cellular metabolic responses and autophagy activity. Abbreviations: bp, base pairs; ChIP, chromatin immunoprecipitation; G6PD, glucose-6-phosphate dehydrogenase; GFP, green fluorescent protein; IDR, intrinsically disordered region; NAD, nicotinamide adenine dinucleotide; NADP+, nicotinamide adenine dinucleotide phosphate; NADPH, nicotinamide adenine dinucleotide phosphate (reduced); ORF, open reading frame; PA, protein A; PCR, polymerase chain reaction; PE, phosphatidylethanolamine; PPP, pentose phosphate pathway; prApe1, precursor aminopeptidase I; ROS, reactive oxygen species; RT-qPCR, real-time quantitative PCR; SD, standard deviation; TF, transcription factor; TOR, target of rapamycin; WT, wild-type.
Changing Role of Specialist Provision in Supporting Inclusive Education: Policy Self-Review Tool
Creators: name: European Agency for Special Needs and Inclusive Education
Publisher: name: European Agency for Special Needs and Inclusive Education
Year: 2022
Subjects: compulsory education
country policy review
data collection
inclusive education
EASNIE
задължително образование
povinná školní docházka
undervisningspligt
Allgemeine Schulpflicht
υποχρεωτική εκπαίδευση
educación obligatoria
kohustuslik haridus
oppivelvollisuus
enseignement obligatoire
obvezno obrazovanje
tankötelezettség
skyldunám
scuola dell'obbligo
privalomasis ugdymas
obligātās izglītība
edukazzjoni obbligatorja
leerplichtonderwijs
obligatorisk skole
kształcenie obowiązkowe
escolaridade obrigatória
povinná školská dochádzka
obvezno izobraževanje
obavezno obrazovanje
obligatorisk utbildning
събиране на данни
sběr dat
dataindsamling
Datenerfassung
συλλογή πληροφοριών / δεδομένων
recopilación de datos
andmete kogumine
tiedonkeruu
collecte des données
prikupljanje podataka
adatgyűjtés
upplýsingaöflun
raccolta dei dati
duomenų rinkimas
datu vākšana
ġbir tad-data
dataverzameling
innsamling av data
gromadzenie danych
recolha de dados
zber dát
zbiranje podatkov
datainsamling
приобщаващо образование
inkluzivní vzdělávání
inkluderende undervisning
inklusive Bildung und Erziehung
ενταξιακή εκπαίδευση
educación inclusiva
kaasav haridus
inklusiivinen opetus
éducation inclusive
uključivo obrazovanje
befogadó nevelés-oktatás / inkluzív nevelés-oktatás
menntun fyrir alla
educazione inclusiva
įtraukusis ugdymas
iekļaujoša izglītība
edukazzjoni inklużiva
inclusief onderwijs
inkluderende opplæring
edukacja włączająca
educação inclusiva
inkluzívne vzdelávanie
inkluzivno izobraževanje
inkluzivno obrazovanje
inkluderande undervisning

description: The Changing Role of Specialist Provision in Supporting Inclusive Education (CROSP) project focused on the re-organisation of specialist provision to support the right to inclusive education for all learners. Phase 2 of CROSP involved developing a roadmap for changing the role of specialist provision. This Policy Self-Review Tool is the main outcome of phase 2. The tool is for policy-makers at national/regional/local level, as well as decision-makers and professionals at school level. It aims to enable them to reflect and develop a continuum of support for inclusive education. It builds upon the strengths and weaknesses of the support that specialist provision provides to mainstream schools for implementing inclusive education for all learners. Download the tool below as a PDF in English or as an open-source Word file in 25 languages. Users are encouraged to build upon and adapt the tool to their own national contexts, with appropriate credit to the Agency.
description: This publication has been funded with support from the European Commission. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
TRIM16-mediated lysophagy suppresses high-gluocse-accumulated neuronal Aβ
Creators: name: Chae, Chang Woo
name: Yoon, Jee Hyeon
name: Lim, Jae Ryong
name: Park, Ji Yong
name: Cho, Ji Hyeon
name: Jung, Young Hyun
name: Choi, Gee Euhn
name: Lee, Hyun Jik
name: Han, Ho Jae
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Lysosomal dysfunction is a pathogenic link that may explain the causal relationship between diabetes and Alzheimer disease; however, there is no information about the regulation of hyperglycemia in neuronal lysophagy modulating lysosomal function. We examined the effect and related mechanisms of action of high glucose on lysophagy impairment and subsequent Aβ accumulation in human induced pluripotent stem cell (hiPSC)-derived neurons, mouse hippocampal neurons, and streptozotocin (STZ)-induced diabetic mice. High-glucose-induced neuronal lysosomal dysfunction through reactive oxygen species-mediated lysosomal membrane permeabilization and lysophagy impairment. Among lysophagy-related factors, the expression of TRIM16 (tripartite motif containing 16) was reduced in high-glucose-treated neuronal cells and the diabetic hippocampus through MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1)-mediated inhibition of TFEB (transcription factor EB) activity. TRIM16 overexpression recovered lysophagy through the recruitment of MAP1LC3/LC3 (microtubule associated protein 1 light chain 3), SQSTM1/p62, and ubiquitin to damaged lysosomes, which inhibited the high-glucose-induced accumulation of Aβ and p-MAPT/tau. In the diabetic mice model, TFEB enhancer recovered lysophagy in the hippocampus, resulting in the amelioration of cognitive impairment. In conclusion, TRIM16-mediated lysophagy is a promising candidate for the inhibition of diabetes-associated Alzheimer disease pathogenesis.