cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Engendering the UN architecture
Creators: name: Baruch, Margot C.
Publisher: name: No Publisher Supplied
Year: 2012

description: Since its inception, the United Nations has been shaped by a multitude of actors. From Member States to academics to civil society, the UN is a unique space where individuals from diverse political, sociological and economic backgrounds join together in an effort to maintain international security and achieve world peace through advancing a development agenda and human rights framework. From its founding, the UN has expanded its presence worldwide as well as enriched its programs and capacities comprised of a wide range of issues including women’s rights. In my thesis, I explore the multi-layered history of women’s rights organizing at the United Nations in an effort to grasp its most recent creation, UN Women. I seek to determine the significance of the impact that women’s rights activists have had on the United Nations and explain the importance of feminist activism in global governance. Therefore, this study analyzes how women’s rights advocates have impacted the United Nations reform process on gender equality architecture.  Women’s rights advocates have been unrelenting in their efforts to establish a more coherent and robust women’s agency at the United Nations (UN). The Gender Equality Architecture Reform (GEAR) Campaign was created to monitor the United Nations reform process and actively lobby for a stronger women-specific agency within the UN. This Campaign proved to be a galvanizing force at a moment when civil society involvement in the UN has been curtailed. Based on primary sources and qualitative findings, I can explain the high level engagement among women’s rights activists and identify the significance of the GEAR Campaign’s contribution to the creation of UN Women. By using qualitative methods, I gained empirical knowledge of the impact advocates had on the reform process since 2005. GEAR has not only ensured the creation of UN Women, but also strategically shaped its form.  My intention with this project is straightforward: I hoped to see what added-value a civil society campaign had on the creation of a UN entity and to document the strategic dedication of women’s rights activists in the development of a global organization tasked to meet the needs of women and girls worldwide. Without a doubt, GEAR was a significant force in ensuring that UN Women was structured to serve women systematically and methodically. Along the way, those advocating for its creation experienced the difficulties created by the UN bureaucracy unflinchingly. Many processes proved overly technical, painfully slow, inconsistent and erratic. When GEAR proponents believed they were close to achieving their goal, the process regressed. Thus feminist activists employed key strategies to advocate for the foundations of a more effective United Nations. They sought to value the lives of women holistically not only in the UN’s programming on gender equality and women’s empowerment, but by the restructuring the organization’s gender architecture.
Conocephalus fuscus
Creators: name: Ostrovsky, A. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Conocephalus
Conocephalus fuscus

description: Conocephalus fuscus (Fabricius, 1793) — Мечник обыкновенный
МатериаΛ. РеспубΛика БеΛарусь, ГомеΛьская обΛ., ГомеΛьский р-н, З окр. Α. Коренёвка, смешанный Λес, верховое боΛото, на зΛаковой раститеΛьности, 23.07.2016, 1♂, 1 нимфа; г. ГомеΛь, забоΛоченная пойма р. Сож, на зΛаковой раститеΛьности, 03.08.2016, 1♂; Ю окр. г. ГомеΛь, НовобеΛицкое Λ-во, забоΛоченная просека, на зΛаковой раститеΛьности, 09.08.2016, 2♀; г. ГомеΛь, б/г р. Сож, на травянистой раститеΛьности, 11.08.2016, 1♀; г. ГомеΛь, пр. Αенина, на свет витрины магазина, 03.07.2019, 1♀; ГомеΛьский р-н, ЮЗ окр. пос. Δубовец, пойменный Λуг в ΑоΛине р. Δнепр, 24.08.2022, 2♀; ЖΛобинский р-н, ЮВ окр. г. ЖΛобин, пойменный Λуг в ΑоΛине р. Δнепр, 07.09.2022, 1♀, 3♀; ГомеΛьский р-н, З окр. СТ «Романтика», Λуг в пойме р. Сож, 17.09.2022, 1♀.
Замечания. Северостепной транспаΛеарктический виΑ. СпециаΛизированный хортобионт, тяготеющий к вΛажным местообитаниям с густой осоково-зΛаковой раститеΛьностью. Обитает ΛокаΛьно во вΛажных биотопах, распоΛоженных в поймах рек, по берегам разΛичных воΑоёмов и на окраинах низинных боΛот. ВкΛючён в Красную книгу РеспубΛики БеΛарусь (Качановский и Αр. 2015).
description: Published as part of Ostrovsky, A. M., 2023, Terrestrial Orthopteroid insects (Insecta, Orthopteroidea) of South-Eastern Belarus, pp. 50-68 in Amurian Zoological Journal XV (1) on page 54, DOI: 10.33910/2686-9519-2023-15-1-50-68, http://zenodo.org/record/11362219
Survivin: Target for Breast Cancer Brain Metastases
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastatic breast cancer to the brain is common in advanced disease and is associated with a poor prognosis. Chemotherapeutic agents, useful in treating systemic breast cancer, have little effect in brain metastases, because the blood-brain-barrier is impenetrable to most drugs. The tumor vasculature also provides necessary nutrients for tumor growth. Preliminary data show that survivin, an inhibitor of apoptosis protein, is over expressed in tumor-associated brain endothelial cells (TuBEC), making these cells resistant to cell death. Blocking survivin production induces apoptosis in other systems. The goal of this project is to induce TuBEC cytotoxicity by targeting survivin. This would destroy the BBB and tumor vasculature thereby eliminating breast cancers in the brain.

 Our objectives are to determine whether:

 1. reducing expression levels of survivin in tumor-associated TuBEC will induce these cells to undergo spontaneous apoptosis.

 2. the results of reducing expression levels of survivin protein in TuBEC will alter their angiogenic properties.

 3. reduced expression of survivin in TuBEC will disrupt the blood-brain-barrier and reduce tumor growth in an animal tumor model.

 The cell culture model will use purified, characterized, primary cultures of human endothelial cells derived from metastatic breast cancer to the brain. The animal model will utilize a novel system of breast tumor cells co-cultured with tumor-associated brain endothelial cells. Survivin production in endothelial cells will be permanently blocked using small interfering RNA (siRNA). Survivin content of cells will be determined by antibody staining and Western blot analysis. Cell apoptosis will be determined using standard assays. Tumors will be evaluated by size, vascular structures, and extent of blood-brain-barrier permeability.

 At this time there are limited effective therapies for patients with metastatic breast cancer to the brain. These studies will provide a new approach to treating metastases in the brain, because it focuses on the tumor-associated brain endothelial cells, the blood-brain-barrier (BBB) itself. The goal is to disrupt the BBB, and destroy the tumor vasculature. This will open the possibility for using a wide range of presently available chemotherapeutic agents for brain metastases. Since anti-survivin therapy may well be an effective anti-angiogenic therapy as well, this agent in conjunction with other drugs at lower doses may be useful in blocking tumor growth.
Decticus verrucivorus
Creators: name: Ostrovsky, A. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Decticus
Decticus verrucivorus

description: Decticus verrucivorus (Linnaeus, 1758) — Кузнечик серый
МатериаΛ. РеспубΛика БеΛарусь, ГомеΛьская обΛ., Брагинский р-н, Ю окр. г. п. Комарин, на разнотравном Λугу, 15.07.2020, 1♀. ΔопоΛнитеΛьный материаΛ: МогиΛёвская обΛ., окр. г. Бобруйск, Λуг в пойме р. Березина вΑоΛь просёΛочной Αороги, 22.07.2017, 1♀.
Замечания. ПоΛизонаΛьный транспаΛеарктический виΑ. ПоΑпокровный геофиΛ. Обычно сеΛится на ярко освещённых соΛнцем сухих Λугах, Λесных поΛянах и Αругих открытых местах. Δержится в гуще травостоя у поверхности почвы. При опасности короткими прыжками быстро скрывается среΑи растений. Питание смешанное.
description: Published as part of Ostrovsky, A. M., 2023, Terrestrial Orthopteroid insects (Insecta, Orthopteroidea) of South-Eastern Belarus, pp. 50-68 in Amurian Zoological Journal XV (1) on pages 54-55, DOI: 10.33910/2686-9519-2023-15-1-50-68, http://zenodo.org/record/11362219
Indian possession and playing
Creators: name: Pierucci, Christine M.
Publisher: name: No Publisher Supplied
Year: 2012

description: Toni Morrison's deconstructionist analysis of the Africanist presence in nineteenth century texts is complemented by analysis of Nativist presence in the same time period and beyond. While the Africanist presence, or lack thereof, helped white authors express the venture for a democratic freedom, the Nativist presence has helped—and continues to help—white authors articulate an American identity which is romantic and distinctly their own, separate from Europe. A number of texts published in the nineteenth and twentieth centuries portray Native Americans in a paradoxical way: the figure is simultaneously the quintessential villain, savage and untrustworthy, and a romantic object of play, resistant to civilization and therefore a figure to be possessed and emulated. At the core of this paradoxical representation is Mark Twain's The Adventures of Tom Sawyer (1876). The novel's villain, Injun Joe, is the epitome of evil, yet the Native American is still the object of Tom'simagination and infatuation. Even while Injun Joe is conveniently left to starve and die in an isolated setting, literally blocked from the rest of the civilization. Tom continues to "play Indian." Twain's novel appears at the transitional period between the nineteenth and twentieth centuries and it captures the ideologies of playing Indian and more specifically, the American ideologies within children's literature. This perpetuation of playing Indian lessons in children's literature is one which should be challenged and critiqued. The project will begin with an interrogation of the literary-historical roots of this cultural tradition, as found in Moby-Dick, The Last of the Mohicans, and Hohomok Then, Tom Sawyer will be employed as the transitional piece between the nineteenth and twentieth centuries, linking theliterary-historical accounts with more contemporary novels and films that exacerbate this trope, including Little House on the Prairie. The Catcher in the Rye, The Indian in the Cupboard, The Bean Trees, Disney's Pocahontas films, and Twentieth Century Fox's Night at the Museum. Rounding out the study is The Absolutely True Diary of a Part-Time Indian, which proves that the American fantasy continually permeates American children's literature and culture.
Molecular Structure of BAG-1:a New Protein in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Like normal breast tissues, many breast tumors depend on estrogens for growth and differentiation. Because of this, for the past three decades, endocrine therapies based on antiestrogens have been widely used to treat breast cancer. This treatment is often effective for patients, but with time the tumors become unresponsive to tamoxifen and the treatment fails. New approaches are needed that don't rely solely on antiestrogens. The focus of this project is BAG-1, a new protein that is linked to the estrogen receptor and makes breast cancer cells resistant to the growth inhibitory effects of tamoxifen. Breast cancer cells continue to grow and divide in the presence of tamoxifen, if BAG-1 is present. The goal of the present study is to generate a molecular image of BAG-1 using the methods of x-ray crystallography and nuclear magnetic resonance (NMR) imaging.

 Our aims are to study a conserved domain of BAG-1 by NMR to gain information on functional properties that might prove useful in future drug design efforts. Previous work by our collaborators has served to isolate BAG-1, develop antibodies for purification and analysis, and understand the mechanism of its cellular functions. To this point, we have been able to produce BAG-1 as either the entire protein or the functional regions, and purify them in preparation for crystallization. A key long-term goal is to study BAG-1’s interaction with another protein, celled Hsp70, which is a key link to hormone responsiveness. It is clear that BAG-1 is associated with hormone responsiveness, but the required structural features and how the smaller protein domains and accessory proteins, such as Hsp70, interact is unclear. The structure will reveal the precise 3-dimensional features of BAG-1 and will provide critical clues linking structure and function.

 These pilot studies could serve as the first step in a drug discovery process for an alternate treatment of breast cancer. The molecular models may offer a new perspective to search for therapies for breast cancer. Since BAG-1 may contribute to treatment failure with tamoxifen or other antiestrogens, the BAG-1 molecule itself may represent a novel target for an entirely new treatment strategy.
Role of Rb Protein and Cell Cycle Defects in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer arises from an accumulation of multiple genetic mutations. Some key types of genes associated with breast cancer include oncogenes (e.g., Her-2), tumor suppressor genes (e.g., p53), and DNA repair genes. Our interest is in a well-characterized tumor suppressor, the retinoblastoma (Rb) protein. The role of this molecule is to regulate the cell cycle and proliferation of breast cancer cells. In this project, Rb and a newly discovered Rb-binding protein (RIZ) will be studied by structural methods. Our goal is to understand the three-dimensional structure of the individual proteins and fragments of these two proteins that involved in their direct binding activity.

 We will use x-ray crystallography to study the interactions between the Rb and RIZ proteins to identify the molecular features of the interactions. Fragments of these molecules that encompass the interacting regions have been cloned and produced in sufficient quantities as recombinant proteins. For structural studies, these proteins will be crystallized alone and in combination. Production of these crystals will be a true breakthrough on the way to determining the structures of the proteins and the critical Rb/RIZ complex.

 Ultimately, atomic models generated from these crystallographic studies will provide a critical insight into the structural and functional roles of these proteins in breast cancer. One possible outcome is to determine whether the PR domain element may represent a new class of tumor suppressors. It has been reported that some breast cancer cell lines that express mutant RIZ proteins lack the PR domain. In addition, RIZ is located on chromosome 1 in a region where deletion (loss of heterozygosity) has been reported for breast carcinoma. Our studies are performed in association with collaborators looking at biological and genetic assays focused on the role of RIZ in cell cycle arrest and apoptosis (programmed cell death). The wide application of purification, cloning, and functional studies on breast cancer genes/proteins provides insights into structure/function. However, the ability to see 3-dimensional picture of these interactions expands our understanding into their dynamic properties.
Agenioideus Ashmead 1902
Creators: name: Enayatnia, Masoumeh
name: Rakhshani, Ehsan
name: Kroupa, Alexander S.
name: Schmid-Egger, Christian
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Agenioideus

description: Genus Agenioideus Ashmead, 1902
Agenioideus Ashmead, 1902:85. Type species: Pompilus humilis Cresson, 1867, by original designation.
description: Published as part of Enayatnia, Masoumeh, Rakhshani, Ehsan, Kroupa, Alexander S. & Schmid-Egger, Christian, 2018, Updated catalogue of Pompilidae (Hymenoptera) in Iran, pp. 451-489 in Zootaxa 4394 (4) on page 454, DOI: 10.11646/zootaxa.4394.4.1, http://zenodo.org/record/1199890
Verrucella klunzingeri Grasshoff 2000
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Ellisellidae
Verrucella
Verrucella klunzingeri

description: Verrucella klunzingeri Grasshoff, 2000
Verrucella klunzingeri Grasshoff, 2000: 113–114, fig. 202&203 (Northern Red Sea).
Opinion: There is not enough evidence that this species occurs in the region.
Justification:
These Indian records seem to be either invalid or unconfirmable: Kumar et al. 2014a: 42, pl. 18, fig. A–D (Andaman Is.); Fernando et al. 2017: 274, pl. 128, fig. A–D (Andaman Is.).
Literature analysis: The publications of Kumar et al. (2014a) and Fernando et al. (2017) present identical descriptions. Although the colony figured by these authors does resemble that illustrated by Grasshoff (2000), the sclerites do not. The densely warted, very short waisted double heads figured from the coenenchyme are quite different to those from Grasshoff’s material, as are the polyp sclerites. Kumar et al. (2015) just lists the species and figure the same Indian specimen, while Kumar et al. (2018a) just lists the species
From the data available, the material described by Kumar et al. (2014a) and Fernando et al. (2017) seems to be the same species as the material Fernando (2011) and Fernando et al. (2017) assigned, perhaps correctly to Verrucella flexuosa (Lamarck, 1815).
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 102, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
A Novel Anti-estrogen Resistance Mechanism in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A widely used treatment of breast cancer patients having estrogen receptor positive (ER+) tumors is to administer anti-estrogens, such as tamoxifen, to block activation of target genes. However, this treatment is effective for only one-half of patients with ER+ tumors, because some tumors display an 'intrinsic' resistance to tamoxifen. In addition, most, if not all, breast tumors that initially respond to anti-estrogens will eventually develop resistance to the treatment. Recently, two breast cancer anti-estrogen resistance genes have been identified that are associated with poor response to tamoxifen and rapid recurrence of disease. The protein products of these genes physically interact and together control activation of cellular signaling pathways. The proteins involved are Bcar1/Cas (a docking protein) and SHEP2 (an exchange factor). Our hypothesis is that if we can understand the physical nature of the interaction between these two proteins, and define the precise region in each protein that is involved, then this knowledge could lead to drug discovery efforts to combat anti-estrogen resistance.

 Our research plan is multidisciplinary and combines cell and structural biological approaches. My colleague at the Burnham Institute, Dr. Kristiina Vuori, is responsible for the cell-based studies in this project. First, the suspected interacting domains of Cas and SHEP will be cloned and the proteins produced in both bacterial and other cell culture systems. We will use selective protein degradation and biophysical approaches (e.g., mass spectrometry) to narrow down the interacting elements for each protein. Secondly, we will introduce regions of each protein into MCF7 breast cancer cells and determine the effect on tamoxifen resistance. In some cases we will perform these experiments with mutant forms of the two proteins to confirm the importance of specific amino acid residues. Finally, we propose to crystallize Cas in complex with SHEP to determine the precise three-dimensional structure of this interaction. This interface may represent a novel target for new drugs to block inherent and acquired resistance to the anti-estrogen response.

 Bcar1/Cas has just recently been linked to breast cancer anti-estrogen resistance, and the association of Cas and SHEP has been described only within the past year. The results of this research will provide new information on the interactions between these domains and advance our understanding of a key drug resistance clinical problem in breast cancer.
Negative affect and coping in caregivers of conduct disordered youth
Creators: name: Olsen, Erika Ann
Publisher: name: No Publisher Supplied
Year: 2012

description: This study aimed to investigate the differences between caregivers of two subgroups of youth with conduct disorder (CD), those with callous-unemotional traits (CU) and those without callous-unemotional traits. The primary focus of this research was to explore the differences of the caregivers across three factors: expression of negative emotions (e.g. anger, fear, anxiety, and depression), coping strategies/interventions, and perceived temperament of their child in toddlerhood. The caregivers from each group were interviewed and given questionnaires to assess their child’s temperament as well as the caregiver’s level of depression, anxiety, and stress. The interviews were transcribed and analyzed. No differences were found across the three variables of interest. The CD caregivers utilized more different types of coping strategies than the CU caregivers; however it is unclear whether or not this finding is the result of chance. This study will serve as a springboard for future research which could potentially aid in the development and implementation of intervention programs for both caregivers and children affected by emotional and behavioral problems.
Novel Ways to Control the Growth of Mammary Epithelial Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Each organ in our body is made up of cells which work together as a team to perform a specific function. To make an organ, the cells must increase in number (i.e., proliferate) and change their behavior (i.e., differentiate), acquiring the skills and teamwork necessary for proper tissue function. Cell proliferation and differentiation are controlled by special proteins, called growth factors or growth hormones. When you are cut, for example, growth factors are made which activate the growth and differentiation of new skin cells to heal the wound. When the wound heals, the growth factors are no longer made. Infrequently, this exquisite regulation breaks down when a single cell’s genetic makeup gets changed by a process called "mutation." Consequently, this cell may alter its behavior and begin to proliferate in an uncontrolled manner. This process can lead to breast cancer when certain cells of the breast, the breast epithelial cells, grow uncontrollably. The growing mass of cells that stay in the breast forms a lump. Other cancer cells, especially those that are no longer differentiated and have "forgotten" they are breast cells, move away to form tumors elsewhere in the body. These undifferentiated cells are the most dangerous.

 Growth factors bind to and activate proteins that sit on the cell’s membrane. Activated growth factor receptors send signals into the cell to trigger cell proliferation and/or differentiation. These signals have to be tightly controlled to prevent unlimited cell proliferation. Growth signals can be stopped when the activated receptors and their bound growth factors are internalized and degraded. Our laboratory studies this process of receptor internalization, called "endocytosis." We have recently discovered that taking activated growth factor receptors into the cell can also change the messages they transmit, tipping the balance between triggering cell proliferation and differentiation.

 The overall goal of my research is to understand the role of endocytosis in controlling the cell’s response to growth factors. Conceivably, we can find a way to tip the balance toward differentiation and away from proliferation. To accomplish this, I propose to analyze how endocytosis affects the balance between differentiation and proliferative signals in breast epithelial cells engineered so that we can experimentally turn endocytosis on or off. Results from these studies will provide insight into novel ways to control breast cancer proliferation.
Agenioideus dichrous
Creators: name: Enayatnia, Masoumeh
name: Rakhshani, Ehsan
name: Kroupa, Alexander S.
name: Schmid-Egger, Christian
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Agenioideus
Agenioideus dichrous

description: Agenioideus dichrous (Brullé, 1840)
Pompilus dichrous Brullé, 1840:92, ♀.
Distribution in Iran: FARS (WOLF et al. 2009), ISFAHAN (WOLF et al. 2009— AS Agenioideus pubescens (MORAWITZ, 1890A)), KHORASAN-E RAZAVI (WOLF et al. 2009), MAZANDARAN (HAUPT 1929A—AS Psammochares ruficeps EVERSMANN, 1849), NORTH KHORASAN (WOLF 2003), TEHRAN (WOLF et al. 2009); NO LOCALITy CITED (WOLF 1990A).
description: Published as part of Enayatnia, Masoumeh, Rakhshani, Ehsan, Kroupa, Alexander S. & Schmid-Egger, Christian, 2018, Updated catalogue of Pompilidae (Hymenoptera) in Iran, pp. 451-489 in Zootaxa 4394 (4) on page 454, DOI: 10.11646/zootaxa.4394.4.1, http://zenodo.org/record/1199890
Leptophyes punctatissima
Creators: name: Ostrovsky, A. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Leptophyes
Leptophyes punctatissima

description: Leptophyes punctatissima (Bosc, 1792) — ПΛастинохвост точечный
МатериаΛ. РеспубΛика БеΛарусь, ГомеΛьская обΛ., г. ГомеΛь, ЦПКО, 07.11.2022, 1♀ (рис. 1).
Замечания. ЗапаΑноевразийский виΑ. СпециаΛизированный тамнобионт. Обитает на хорошо освещённых соΛнцем окраинах Λиственных Λесов, а также в гороΑских саΑах и парках. Обычно Αержится в живых изгороΑях и кронах кустарников вΑоΛь Αорог. РаститеΛьнояΑен. Не Λетает. Впервые указывается в своΑке И. Г. Крицкой (1988) ΑΛя запаΑной границы БеΛаруси. Вероятен завоз в парковую зону вместе с Αекоративной раститеΛьностью. Meconema thalassinum (De Geer, 1773) — УзеΛкоус европейский
МатериаΛ. РеспубΛика БеΛарусь, ГомеΛьская обΛ., г. ГомеΛь, ЦПКО, 08.10.2016, 1♀; там же, 24.09.2022, 1♀; там же, 07.11.2022, 1♀; г. ГомеΛь, уΛ. Крестьянская, на наружной стене зΑания, 30.09.2022, 1♀.
Замечания. ЗапаΑноевразийский виΑ, интроΑуцированный в Северную Америку. СпециаΛизированный тамнобионт. Обитает в Λиственных Λесах, парках и саΑах, Αержится в кронах разΛичных Αеревьев и кустарников. Активен с вечера. Питание смешанное.
description: Published as part of Ostrovsky, A. M., 2023, Terrestrial Orthopteroid insects (Insecta, Orthopteroidea) of South-Eastern Belarus, pp. 50-68 in Amurian Zoological Journal XV (1) on page 55, DOI: 10.33910/2686-9519-2023-15-1-50-68, http://zenodo.org/record/11362219
Molecular Characterization of ErbB2 Positive Breast Cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The ErbB2 protein is increased in 20-30% of all breast cancers, and this is associated with poorer clinical outcome. Thus, there has been substantial interest in targeting ErbB2 for drug development, and a need to understand more about molecular events surrounding ErbB2 activity. The role of ErbB2 in breast cancer is complex, because less than 20% of tumors respond well to the ErbB2-targeted therapeutic, trastuzumab (Herceptin). This low response indicates that a better understanding of how ErbB2 functions will lead to new, more effective and individualized therapeutics.

 Recent research indicates that the protein ESX, a member of a family of proteins called Ets factors, is involved in ErbB2 signaling. ESX is found expressed in ovarian and breast cancers. Our hypothesis is that ESX will be associated with ErbB2 signaling, and be a useful marker for classifying ErbB2 positive breast cancer. Initially we will establish the model systems by expressing ESX or ErbB2 in breast cells lines that do not normally express these proteins. These model cell lines will also be used to generate tumors in mice. The tumors will provide both a physiological model and a platform to define the genetic differences underlying the presence of ESX and/or ErbB2. We plan to find the genes that are regulated by ErbB2 and ESX using DNA microarray technology. This allows us to simultaneously assay 8,000 human genes, including all the known Ets factors, apoptosis (cell death) factors, and all known ErbB2 signaling intermediates. By modulating ErbB2 and ESX levels in breast cancer cell lines we can identify critical genes that associated with these changes. We are looking for a subset of genes that reflect the contribution of ESX to ErbB2-mediated cell signaling. For these studies we have the infrastructure support in bioinformatics and biostatistics through the University of California, San Francisco breast cancer SPORE. (http://cc.ucsf.edu/breast_spore/).

 We are using a directed approach, based on recent data from our research and addressing a key clinical need, to improve our ability to treat ErbB2 positive breast cancers. This will be the first survey of genes regulated by any Ets factor or ErbB2 using this approach. It will also be the first detailed analysis of the differences between a cell line and the resulting tumor gene expression profiles with a common genetic origin. These data will provide valuable insight into the biological role of ESX, its contribution to the pathogenesis of breast cancer and allow evaluation of models commonly used to study breast cancer. Ultimately, the goal is to develop better therapeutics for ErbB2-overexpressing tumors.
Novel Enzymes Associated with Breast Cancer Angiogensis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tumors need a blood supply in order to increase in size and for their spread (metastasis) throughout the body. Tumors are able cause surrounding normal tissue to supply a increased number of blood vessels for growth and spread in the body. A variety of approaches and novel therapeutics are being investigated to block of new blood vessel formation. However, there remain many undiscovered aspects of angiogenesis, since the underlying biology is so complex. A key element that links tumor cells, blood vessels, and normal tissues is the extracellular matrix. It is composed of a variety of proteins and protein-sugar macromolecules (proteoglycans) that serve as barriers to angiogenesis and cell movements. Proteoglycans also can bind soluble factors that regulate the growth of new blood vessels. One of the key proteoglycans is heparan sulfate (HS). We have discovered two new enzymes that could potentially degrade HS, and represent potential factors produced by breast cancer cells that may be involved in the regulation of angiogenesis.

 Based on a virtual northern analysis, our preliminary evidence is that two novel HS degrading enzymes are increased in human breast cancer samples as compared to normal breast tissue We will use recombinant DNA techniques to provide us with the tools to measure the presence of the genes, and the amount protein products from these genes. Finally, we will use mouse models of breast cancer to test whether the HS degrading enzymes are really required for the growth of new blood vessels in tumors.

 We are studying new genes that have not previously been considered in the context of cancer biology. We have a plausible theory of how this type of gene could contribute to the formation of new blood vessels in tumors. If our hypothesis is correct, then these enzymes could be studied with the aim of developing a new class of anti-angiogenic drug.
Agenioideus arenicola
Creators: name: Enayatnia, Masoumeh
name: Rakhshani, Ehsan
name: Kroupa, Alexander S.
name: Schmid-Egger, Christian
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Agenioideus
Agenioideus arenicola

description: Agenioideus arenicola (Priesner, 1955)
Pompilus (Sericopompilus) arenicola Priesner, 1955:72, Syntypes ♀ ♂.— Egypt, many locations (NHMW).
Distribution in Iran: FARS (FALAHATPISHE et al. 2016), SISTAN-O BALUCHESTAN (WOLF et al. 2009).
description: Published as part of Enayatnia, Masoumeh, Rakhshani, Ehsan, Kroupa, Alexander S. & Schmid-Egger, Christian, 2018, Updated catalogue of Pompilidae (Hymenoptera) in Iran, pp. 451-489 in Zootaxa 4394 (4) on page 454, DOI: 10.11646/zootaxa.4394.4.1, http://zenodo.org/record/1199890
Caspase-mediated Apoptosis Mechanisms in Breast Cancer Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Genetic instability is an essential feature in the development of all cancers, including those of the breast. Most solid tumors are found to contain various chromosomal abnormalities, some that result from the failure to properly distribute chromosomes between daughter cells during cell division. A failure to properly separate these "sister" chromatids results in a state called aneuploidy. Thus, cancer cells can have extra copies of chromosomes. Our interest is in the process of chromosome separation, the proteins involved, and the identification of the defects associated with genetic instability in cancer. During cell division the sister chromatids are held together by a protein called "ssc1". The cleavage of ssc1 is required to allow proper chromosome segregation and is accomplished by a protease called "separase". In turn, separase activity is controlled by a second protein, called "securin". Our interest is to extend our understanding of this process to breast cancer with the hypothesis that excess securin might be an underlying cause in genetic instability.

 The specific aims of this project are to (i) determine the proteolytically active form of separase, (ii) examine the mechanism for modulation of separase activity by securin, and (iii) profile separase activity in breast cancer cells and in normal cells of the breast epithelia and correlate this activity with the levels of securin at the mRNA and protein levels. To accomplish these aims, we propose cloning, over-expression, and biochemical analyses of separase. Cell culture experiments will be done to study separase in HeLa cells. We plan to identify additional proteins that bind to separase using affinity columns.

 Cancerous cells lose the ability to halt division at normal cell cycle checkpoints and instead divide unchecked. The resultant abnormal mitoses lead to genetic abnormalities such as aneuploidy, which can provide a further growth advantage and promote the malignant phenotype. A better understanding of how aneuploidy occurs in breast cancer may yield novel ways to prevent the disease.
Identifying Sources of Genomic Instability in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Human cancers at diagnosis have dramatic changes in their chromosomes, including large deletions, duplications, and rearrangements of DNA segments. The DNA damage checkpoint is a cellular surveillance system that helps to maintain genomic stability by sensing the presence of DNA damage. When this system works properly, it coordinates an appropriate and effective cellular response to that damage. The basic molecular mechanisms that underlie DNA checkpoints and damage control/repair are well conserved in evolution. Thus, it makes sense to explore these processes in animal models, especially those where the genes and proteins of interest are better characterized and might be studied more effectively. In our laboratory, we use the eggs from Xenopus, a frog, as a model system. These eggs can be used to make a protein extract in which we can manipulate the proteins of interest and perform larger-scale biochemical studies. Using this model system we can induce DNA damage with UV light and determine how DNA damage response proteins interact with each other.

 Recent research has led to the hypothesis that checkpoint signaling requires assembly of a protein complex at sites of DNA damage. In our previous work we showed that two proteins, called ATR (ataxia telangiectasia related) and Rad1, bind to chromatin and are needed to phosphorylate several other proteins that are critical to the damage response. One of these key proteins is BRCA1, which when mutated leads to hereditary breast cancer. Thus, our approach is to identify other key proteins in Xenopus egg extracts, by detecting the proteins that become phosphorylated in response to UV damage. We plan to isolate and partially sequence these DNA damage repair genes with a colleague at Harvard University. Our next aim is to translate this information to breast epithelial cells. This will involve determining the human counterparts of our Xenopus genes using published gene/protein databases. Then, we can use a new approach, called "small interfering RNA" (siRNA) to dissect out which human DNA damage repair genes are operative in breast cells, and identify the ones that might be worthy of future study in the context of breast cancer progression.

 Our CBCRP-funded project is logical, because mutations in checkpoint proteins and related targets have already been shown to predispose individuals to breast and other cancers. It seems likely that identification of these phosphorylated proteins could lead to an understanding of genomic stability in breast epithelial cells. With a complete cataloguing and detailed information on the full spectrum of DNA repair proteins and checkpoint control in breast epithelial cells, we would be in position to evaluate them for potential diagnostic/detection uses and therapeutic targets.
Group Intervention for Women at High Risk for Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This study is a group intervention for women at high risk for breast cancer. It addresses the Breast Cancer Research Program's priority issue involving improved access for underserved populations, specifically women at a high risk of developing breast cancer. Thus far, no viable group interventions have been developed for this population. The purpose of this study is to identify and develop a multidisciplinary and multispecialty organizational model of service delivery by defining the content and characteristics of the best group model to increase education, prevent the development of psychological symptoms and problems, and increase adaptation and coping to the threat these women live with daily. A special effort will be made to recruit minority women, since to date, most work in this area has been on Caucasian women. The study additionally addresses the psychosocial and behavioral consequences of elevated genetic risk for breast cancer.

 Specific aims of the project include: 1) to test the viability of the group model in terms of content, interest, effectiveness, attendance, and optimal participant mix; 2) to test the feasibility of the group model in terms of decreasing the participants' adverse psychological and behavioral symptomatology; 3) to test the feasibility of the group model in terms of increasing knowledge of nutrition and its relationship to increased cancer risk; 4) to test the feasibility of the group model to facilitate a more realistic assessment of personal cancer risk; 5) to test the feasibility of the group model in terms of increasing knowledge of positive coping methods; and 6) to test the feasibility of the group model in reduction of grief symptoms.

 If this group model proves feasible, it will be possible to shift focus to long-tem retention of high risk women in appropriate clinics and other settings which would promote earlier detection and diagnosis, thus reducing mortality and morbidity from this disease.
SECRETed_7th_Newsletter
Creators: name: EXELISIS IKE (Greece)
Publisher: name: Zenodo
Year: 2025
Subjects: dissemination
newsletter
SECRETed
surfactants
siderophores
biology
combounds
encapsulation
cosmetics
biotechnology
agrochemicals
pharmaceuticals
nutraceuticals
food supplement
antitumor
diagnostics

description: 1. Contributing to the Circular Economy

2. Achievements

3. Events

4. Upcoming Webinar

5. Stay Connected
The UC Consortium on Criminal Justice Healthcare
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: ABSTRACT / PROJECT SUMMARY The proposed UC Consortium on Criminal Justice Healthcare will build the infrastructure for a UC-wide community of scholars to address the pressing need for interdisciplinary leadership and innovation in criminal justice healthcare research. The U.S. has the world’s highest incarceration rate and California leads the nation with the most persons in jails, prisons, or on parole or probation. Yet the impact of widespread incarceration on individual and community health, and interventions to address these adverse consequences are only beginning to be investigated. In this research void, policymakers are searching for evidence to guide reform and administrators are searching for innovative care models. Meeting the urgent health needs of criminal justice-involved individuals and their communities will require interdisciplinary expertise from diverse fields such as medicine, psychology, law, sociology, economics, public policy, and others. The Consortium will address this pressing need by building UC-wide interdisciplinary research capacity, attracting and developing faculty and students to become future leaders in this field, and positioning UC as a leader in innovation and evaluation of new healthcare models and policies to shape criminal justice health reform and improve the health of millions of Californians and their communities. The PIs - Brie Williams MD, UCSF; Craig Haney PhD JD, UCSC; and Scott Allen MD, UCR - are nationally recognized leaders working in criminal justice and health. Under their leadership, and with a UC-wide Governing Board and a nation-wide Advisory Board, the Consortium will engage faculty and students from all ten UC campuses to generate new interdisciplinary research collaborations leading to: 5 or more policy briefs disseminated to criminal justice policymakers; 5 or more submitted manuscripts; 5 student presentations at a national healthcare conference; 5 faculty presentations at national conferences in their fields; 2 Consortium-funded multi-campus pilot projects; and applications for 2 career development grants, 2 faculty research grants, and 1 program level grant for Consortium sustainability. With its breadth of faculty and student talent across institutions, and its mission to be “a public research university for, by, and of California,” UC is uniquely poised to lead the way in creating a coordinated, interdisciplinary, statewide research response to address the criminal justice healthcare crisis in California and nationwide.
Genetic Alterations in MRI Screen-Detected Breast Lesions
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The genetic events that underlie the progression of normal breast tissue to that of increasingly malignant potential remain poorly understood. In our laboratory, we recently discovered that the tumor suppressor gene BRCA1 may be critical to this process by regulating DNA repair and genomic stability. We now propose a research project to translate our laboratory findings to the clinic. We propose to examine specific genetic events that may be critical to the development and progression of malignancy in women at high risk for breast cancer due to inherited BRCA1 mutations. We are particularly concerned about the malignant potential of breast lesions that are detected on an MRI screening examination and shown to be histopathologically benign. We suspect that these lesions may have undergone premalignant genetic changes. To address this concern, we propose collaborative program that brings together clinical investigators with expertise in MRI breast screening and basic science investigators with expertise in the DNA repair genes and genomic stability.

 In this pilot study, we propose to test the central hypothesis that benign breast lesions that are screen-detected on MRI have already undergone specific genetic alternations that may be associated with breast carcinogenesis. If we find evidence of this effect, we will pursue a longer-term follow-up study where we hope use these preliminary results to identify the specific multi-step genetic alternations that underlie the progression of normal breast tissue to premalignant and malignant breast disease.

 Women will be recruited from Stanford's Breast Cancer Genetics Clinic which draws patient from the culturally diverse San Francisco Bay Area. Women who test positive for the BRCA1 mutation will be invited to our study. To test our central hypothesis, we will analyze benign breast lesions, premalignant and malignant lesions that are screen-detected by MRI and determine if these lesions contain mutations in the tumor suppressor genes BRCA1 and p53. Among lesions that have undergone these additional genetic mutations, we will analyze them for changes in the expression levels of DNA repair genes that are regulated by the BRCA1 and p53 genes.

 We aim to be the first to analyze the DNA repair genes of benign breast lesions screen-detected by MRI. Demonstrating these premalignant events may have two significant long-term outcomes. First, our work could become the basis that makes MRI screening for premalignant disease more clinically relevant. Second, our work may reveal specific genetic events in breast carcinogenesis that may be critical in breast cancer risk reduction and prognosis.