cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Amphilophus globosus Geiger, McCrary & Stauffer 2010
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Cichlidae
Amphilophus
Amphilophus globosus

description: Amphilophus globosus Geiger, McCrary & Stauffer 2010. Round-Bellied Cichlid; Mojarra de Vientre Redondo
Vouchers: (other collections) PSU 4742 (6), 4743 (1), 4744 (2), 4745 (1), ZSM 38822 (1), 38755 (1), 38756 (1), 38757 (1), 38758 (3) and 38759 (3). Distribution: Central America; endemic to the Lago Apoyo, Nicaragua; (Nicaragua) LN (Atlantic); 73– 73 masl; Sec, Pot. Occurrence and conservation status: Nat, End; CR B1ab(iii) (2020), population trend decreasing. Literature: Geiger et al. (2010: 164; original description).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 49, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Identification of Inhibitors for SIV Nef-PAK Interaction
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Nef, a viral protein expressed by the Simian Immunodeficiency Virus (SIV) and the Human Immunodeficiency Virus (HIV) has been shown to be important for pathogenesis in rhesus macaques and humans, causing Acquired Immunodeficiency Syndrome (AIDS) and Simian AIDS. Nef is capable of enhancing virus infectivity, downregulating cellular proteins for immune system evasion and participating in cellular activation. We have shown that Nef binds and activates a member of the p21-activated kinase (PAK) family, a cellular protein. Nef mutants have shown that Nef-mediated PAK activation correlates with virus progression to AIDS These results demonstrate the importance of the Nef-PAK interaction to the virus. Therefore, inhibition of the Nef-PAK interaction by small molecules are predicted to lower viral replication and prevent disease progression. To further study the Nef-PAK interaction, we have identified small molecule compounds that inhibit PAK activation by Nef. We have expressed and purified SIV Nef protein and used it to screen collections of small molecules to identify compounds that bind Nef. After screening 410,000 compounds from four different collections, we have identified several small molecules that bind to SIV Nef. Compounds were tested for their ability to inhibit Nef-mediated PAK activation using an in vitro assay on SIV and HIV Nef expressed by mammalian cells. A family of compounds was found to inhibit SIV and HIV Nef activity by reducing Nef-associated PAK activation. These compounds can also inhibit the Nef-PAK interaction from SIV-infected cells. Current work focuses on enhancing compound specificity and potency by screening secondary libraries. We hypothesize that small molecules that inhibit Nef-mediated PAK activation will lower SIV and HIV replication. The long-term goal of this project is to determine if the compounds can prevent disease progression with the SIV-rhesus macaque model. It is hoped that compounds identified in these studies will represent a new class of HIV inhibitors that can complement current therapies.
Contested conservation of the snowmobile commons
Creators: name: Andrews, Marguerite L.
Publisher: name: No Publisher Supplied
Year: 2014

description: Nearly half of Maine’s 16 million acres of privately-owned forestland has changed hands in recent decades. As the vast industrial forest contracts under the pressures of new development and land use constraints, the effects of these changes are strongly felt by a rural populace already contending with job losses and other consequences of economic restructuring. Local communities have expressed particular concern about the impacts shifts in land ownership and management are having on Maine’s “open land tradition”—the longstanding right of the public to permissively access and use private lands. Several new conservation landowners have levied restrictions based upon environmental ethics and values that exclude some customary uses of the land, and these owners have consequently emerged for many north woods residents as the greatest threat to the private commons.     Using snowmobiling as an entry point, this research grounds these large-scale economic and environmental transformations and ensuing resource conflicts within the north woods communities being affected. I examine how snowmobiling—arguably the most contentious land use in present-day disputes—is deeply rooted in the working forest, its tradition of common property, and rural Maine’s communities, cultures, and economies. The activities of snowmobilers, their social relations, and institutional arrangements together comprise the snowmobile commons. My research contends that snowmobiling helps to make visible various practices of stewardship, local histories and heritages, collective involvement in land management, and the diverse economies that exist in Maine’s forests. Ultimately, this dissertation reveals that the heritage of snowmobiling in Maine and its integration with various aspects of rural life have left indelible physical, economic, and cultural imprints on the landscape that are not easily swept away by seemingly inevitable forces of change.    This research extends First World political ecology scholarship by exploring the history and culture of America’s snowbelt, offering new insights into the diversity and viability of common property regimes, and reframing discourses of rural restructuring and studies of the transition to post-productivism in the global north. I employed a combination of research methods including in-depth interviews with key informants, participant observation, and analysis of formal and informal documents.
Glossodrilus dudichi Zicsi 1995
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Glossodrilus
Glossodrilus dudichi

description: Glossodrilus dudichi Zicsi, 1995
Glossodrilus dudichi Zicsi, 1995a Opusc. Zool. (Budapest) 27–28: 98.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 19, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Additional file 1: Table S1. of Muscle force distribution of the lower limbs during walking in diabetic individuals with and without polyneuropathy
Creators: name: Gomes, Aline
name: Ackermann, Marko
name: Ferreira, Jean
name: Orselli, Maria
name: Sacco, Isabel
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Mean (± 1 standard deviation) of hip, knee and ankle joint maximum flexion, maximum extension and range of motion (ROM) of the control (CG), diabetic (DG) and diabetic neuropathy (DNG) groups during gait cycle. Figure S1. Mean (± 1 standard error) of the hip, knee and ankle angular displacement of the control group (CG) in green, diabetic group (DG) in blue and diabetic neuropathy group (DNG) in red throughout the gait cycle. Table S2. Mean (standard deviation) of hip, knee and ankle joint moments during the stance phase of gait. Figure S2. Mean (± 1 standard error) of the hip, knee and ankle joint moments (normalized by body weight and height) in the control group (CG), diabetic group (DG) and diabetic neuropathy group (DNG) during the gait cycle. Table S3. Ankle muscle’s peak force values (mean ± standard deviation) normalized by body weight (BW) of diabetic neuropathy (DNG), diabetic (DG) and control (CG) groups during the gait cycle. Figure S3. Mean (± 1 standard error) of the force time series for the knee flexors muscles (bicep femoris long head and semitendinosus), knee extensor muscles (vastus intermedius and rectus femoris), ankle flexor and extensor muscles (extensor hallucis longus and flexor hallucis longus) and ankle evertor muscles (peroneus longus and peroneus brevis) in the control group (CG - green), diabetic group (DG – blue), and diabetic neuropathy group (DNG – red), during the gait cycle. (DOCX 970 kb)
Have freedom, will travel
Creators: name: Ali, Isra
Publisher: name: No Publisher Supplied
Year: 2014

description: This project examines how women traveling from North America and Western Europe to Afghanistan in the era of the War on Terror go about making media about Afghan women, and considers the experience of contemporary travelers alongside those of European women who traveled to the Muslim world in the 18th, 19th, and 20th centuries. This work expands on and revises existing cultural studies scholarship on the representation of brown bodies in a post 911 world, using an anti-colonial lens to examine the work of journalists, independent documentary filmmakers, and activists. It pays particular attention to the varied ways in which the concept of feminism is deployed to advocate for or against ongoing military occupation of Afghanistan. This project asks: what is the relationship between feminism, Afghan women, and the War on Terror? It examines articles, broadcasts, images, films and websites, produced about Afghan women alongside interviews, memoirs, and other materials these traveling women make about their own experiences of being “liberated” women working within the danger of the war zone and the “traditional” culture of Afghanistan. It examines intersections of race, ethnicity, citizenship, and class with gender through an analysis of the term traveling women use to describe their experience of being foreign and female in Afghanistan – the ‘third sex.’ This work traces how the ‘third sex’ come to be in Afghanistan after 911, and how they access Afghan women. This makes visible the networks of media, military, and non-governmental agencies they rely on there and how these relationships shape news output in the war zone. I then parse out the conflicting perspectives of liberal feminists and radical feminists as they emerge online in the discourse on militarism and Afghan women’s liberation, making visible the relationships amongst Afghan and non-Afghan feminist organizations and media outlets. The conflicts that emerge amongst liberal and radical feminists are indicative of the challenges that arise when feminists attempt to articulate cross-cultural, global, concepts of gender equality and liberation. These challenges are compounded by the context of the War on Terror, and the use of humanitarian logics to rationalize military endeavors.
Glossodrilus griseus Zicsi & Feijoo 1994
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Glossodrilus
Glossodrilus griseus

description: Glossodrilus griseus Zicsi & Feijoo, 1994
Glossodrilus griseus Zicsi & Feijoo, 1994 Mitt. Hamb. Zool. Mus. Inst. 89 (2): 57.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 20, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
A Targeted Therapy for Wound-like Breast Cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Each time a person cuts a finger, a remarkable choreography of genes and cells unfolds. Cells that are normally dormant are now invigorated to divide rapidly, remodel the matrix around themselves, migrate across tissue planes, and send forth chemical signals to recruit new blood vessels-all in an effort to close up the wound. These dramatic processes in wound healing may also constitute the ideal genetic tools for cancer metastasis. We discovered that some breast cancers exhibit wound-like features and can be distinguished by a gene expression signature--a specific pattern of 512 genes. In a survey of 295 early stage breast cancers, approximately 40% of tumors exhibited the wound signature, and these patients have a three-fold increased risk of death. The wound signature identified these high risk tumors independently of known risk factors for poor outcome. Therefore, therapies that specifically target cells exhibiting the wound signature are needed for patients with wound-like breast tumors. Recently, we discovered that mutations in a novel combination of two cancer promoting genes, MYC and CSN5, are responsible for wound signature activation in breast tumors. The collaboration between MYC and CSN5 depended on abnormal protein turnover, a process that may be blocked by the FDA-approved drug bortezomib (Velcade®). It is the first in a new class of medicines called proteasome inhibitors. This drug is currently used to treat multiple myeloma in patients who have received at least one treatment that has not helped.

 Our specific aims are, first, to test the ability of bortezomib to kill human breast cancer cells with the wound signature. A panel of human breast cancer cells exhibiting different levels of activity of the wound signature will be tested for sensitivity to bortezomib during growth in laboratory cultivation. The results will demonstrate whether the wound signature can predict the sensitivity of human breast cancer cells to bortezomib. Secondly, we will test the ability of bortezomib to inhibit the growth of mouse breast tumors exhibiting the wound signature. Introduction of MYC and CSN5 into mouse mammary glands creates breast tissues mimicking human breast cancers with the wound signature; we will test whether bortezomib treatment can cure or inhibit the growth of such mammary tumors. These studies will use physiological and molecularly precise models of a high-risk breast cancer to test the utility of a therapy

 Although genetic studies have detailed increasingly specific subtypes of human breast cancers, there has been no specific treatment for these newly classified patients. Our study of bortezomib is one of the first to test a targeted therapy based on the understanding of the gene expression program of human breast cancers.
Microchaetus rappi Beddard 1886
Creators: name: Jadwiga Danuta Plisko
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Microchaetus
Microchaetus rappi

description: Microchaetus rappi Beddard, 1886
Microchaeta rappi: Beddard, 1886 b: 63; Horst 1891: 77; Beddard 1895: 669; Plisko 1999: 273.
Microchaeta Rappii [invalid emendation of rappi]: Beddard 1886 b: 306; 1895: 669; Coles 1981: 276.
Microchaeta Rappi: Rosa 1891: 380; Benham 1886 b: 87.
Antaeus microchaeta [partim]: Vaillant 1890: 185 [invalid emendation of Anteus].
Microchaeta? microchaeta [partim]: Vaillant 1890: 186; Reynolds & Cook 1976: 60.
Microchaetus microchaetus [partim]: Michaelsen 1900: 451.
Microchaetus microchaetus var. typica [partim]: Michaelsen 1900: 451.
The type locality suggested to be ‘Breakwater, Cape Town’ (Beddard 1886 b) is probably
erroneous, and should be Grahamstown, Eastern Cape.
description: Published as part of Jadwiga Danuta Plisko, 2006, A systematic reassessment of the genus Microchaetus Rapp, 1849: its amended definition, reinstatement of Geogenia Kinberg, 1867, and erection of a new genus Kazimierzus (Oligochaeta: Microchaetidae), pp. 31-56 in African Invertebrates 47 (1) on page 39, DOI: 10.5281/zenodo.160162
Arthrosolaenomeris pantanalensis Schubart 1943
Creators: name: Bouzan, Rodrigo Salvador
name: Iniesta, Luiz Felipe Moretti
name: Brescovit, Antonio Domingos
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Chelodesmidae
Arthrosolaenomeris
Arthrosolaenomeris pantanalensis

description: Arthrosolaenomeris pantanalensis Schubart, 1943
BRAZIL • 1 ♂; Mato Grosso, São Luiz de Cáceres (now Cáceres); 16°04′15″ S, 57°40′44″ W; Feb. 1940; Passarelli coll.; MZUSP 1085 • 1 ♀; Porto Estrela, E.E. Serra das Araras; 15°19′28″ S, 57°13′39″ W; 12 Nov. 2017; T.F. Conceição coll.; CZUFMT MYR 847.
description: Published as part of Bouzan, Rodrigo Salvador, Iniesta, Luiz Felipe Moretti & Brescovit, Antonio Domingos, 2019, Cladistic analysis and description of a new species of the Brazilian genus Atlantodesmus Hoffman, 2000 (Diplopoda: Polydesmida: Chelodesmidae), pp. 1-17 in European Journal of Taxonomy 538 on page 15, DOI: 10.5852/ejt.2019.538, http://zenodo.org/record/3346493
Amphilophus labiatus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Cichlidae
Amphilophus
Amphilophus labiatus

description: Amphilophus labiatus (Günther 1864) (Fig. 8J). Red Devil; Mojarra Picuda, Diablo Rojo
Vouchers: UCR 0190-002 (12), 0242-001 (16), 0470-001 (3), 0471-001 (4), 0472-001 (5), 0476-001 (5), 0479-002 (2), 0480-002 (5), 0536-003 (3), 0540-002 (6), 0546-003 (11) and 0550-005 (5); FMNH 5997 (5), 5998 (3), 6000 (29), 5970 (2), 5971 (1), 5972 (1), 5973 (1),5975 (5), 5976 (3), 5977 (3), 5978 (1), 33019 (3), 52526 (1), 52534 (2) and 84893 (10); LSUMZ 16986 (5) and 16987 (42); other collections: CAS 58970 (100), 59258 (1), 76043 (34), 76186 (12), 76222 (1), 61532 (2), KU 18703 (1), 18708 (1), 18709 (1), 18710 (1) and 22963 (1). Distribution: Central America; from southern Nicaragua to northern Costa Rica, Atlantic drainages; (Nicaragua) LN (Atlantic); 30–31 masl; Sec, Pot. Occurrence and conservation status: Nat; NE, population trend unknown. Literature: Meek (1907: 123, as Cichlasoma labiatum —synonym, also as Cichlasoma lobochilus (Günther 1867) —misidentification and Cichlasoma dorsatum (Meek, 1097) —misidentification; brief description, including an identification key, and information on distribution and ecology), Astorqui (1975: 129, as C. labiatum —synonym; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 192; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 312, as Amphilophus citrinellus, in part—misidentification; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Stauffer & McKaye (2002: 8; comparative morphological data and information on distribution), Stauffer et al. (2008: 117; comparative morphological data and information on distribution), Klingenberg et al. (2003: 397; body shape variation and comparison, teeth morphology, and distribution), Angulo (2021: 47; listed, including information on distribution) and Angulo & San Gil-León (2022: e4029; identification key and information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 49, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Enhancing Trastuzumab Therapy with an NK Activating Antibody
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Monoclonal antibodies which target cancer are among the most notable scientific advances in the last quarter century. Rapid translation of this research has prolonged the survival of thousands of patients with breast cancer through development of trastuzumab (Herceptin) which targets HER2/neu oncogene expressing breast cancers. Despite the promising activity of trastuzumab, the response rate among patients with advanced cancer is suboptimal. The anti-tumor activity of trastuzumab is dependent, in part, upon the patient’s immune response, which recognizes and destroys antibody-bound tumor cells. Specifically, this tumor-killing mechanism is through antibody dependent cell-mediated cytotoxicity (ADCC) whereby a natural killer (NK) cell bearing an Fc receptor binds to the antibody-targeted tumor cell and ultimately mediates the killing function. Unfortunately, conventional cytotoxic chemotherapies (e.g. antracyclines) induce myelosuppression, decreasing the population of NK cells, thereby reducing the efficacy of ADCC. Thus, therapies which augment NK cell function uniquely offer the ability to improve activity of monoclonal antibodies without increasing toxicity to non-cancer cells. We have recently demonstrated that ADCC function can be augmented and target cell killing can be enhanced by a second antibody against CD137, an NK “activating” cell surface molecule.

 Thus, in this project we will test whether triggering the activation marker, CD137, on NK immune cells will enhance the anti-tumor efficacy of trastuzumab therapy against HER2/neu expressing breast cancer. First, we will demonstrate increased NK cell expression of CD137 following NK cell exposure to trastuzumab-targeted breast cancer. Second, we will investigate if stimulation of activated NK cells with anti-CD137 antibody enhances cytotoxicity against trastuzumab-targeted breast cancer in cell models. Finally, we will determine if treatment of xenografts (a mouse model) of human breast cancer is enhanced by anti-CD137 antibody together with trastuzumab.

 Of the women with HER2-positive metastatic breast cancer, 60% do not respond to trastuzumab-based combination chemotherapy, and significant cardiac toxicity has been observed. Therefore, even though significant advances in cancer treatment have been made through monoclonal antibody therapy, there exists a substantial need for improvement. We are confident that the underlying biological rationale for combination of trastuzumab with a CD137 antibody will result in enhanced anti-breast cancer efficacy.
Prevalence of pathogens and indicators in foods ordered from online vendors
Creators: name: Agarwal, Munira
Publisher: name: No Publisher Supplied
Year: 2014

description: The widespread availability of the Internet has fostered the emergence of a new business sector: online sales of perishable foods. While there is an abundance of information available on safe food handling practices in homes, retail and foodservice establishments, the same can not be said for the handling of ‘mail-ordered foods’. This project used microbial techniques to identify bacterial foodborne pathogens and indicator organisms in foods ordered online.     Randomly chosen food items were ordered from different online vendors. On arrival of the package containing the food, details such as the packaging materials used, temperature of food, presence of coolants etc. were recorded. Frozen samples were thawed at 2-5°C for no more than 18 hours. Food samples were enumerated for the presence of indicator organisms including total plate count, coliforms and generic E. coli, and tested for the presence of pathogens including Salmonella, pathogenic E. coli, Listeria monocytogenes, Clostridium perfringens, Bacillus cereus, Staphylococcus aureus, and Vibrio parahemolyticus. Testing protocols were based on US Food and Drug Administration (FDA) Bacteriological and Analytical Manual (BAM).      A total of 341 samples were tested (196 meat, 34 poultry, 111 seafood). Of these, 18.&% were positive for generic E. coli, 9.9% for pathogenic E. coli, 10.2% for Salmonella, 50.3% for B. cereus, 38.&% for V. parahemolyticus and 18.2% for C. perfringens. Also, on comparing incidence rates of food pathogens it was found that prevalence of Salmonella, B. cereus and V. parahemolyticus was higher in most of the mail-ordered foods than foods from other retail sources and prevalence of E. coli and C. perfringens was lower in most mail-ordered foods than foods from other retail sources. The temperature recorded on arrival of samples showed that majority of the coliforms, B.cereus, C. perfringens and L. monocytogenes positive samples were received at acceptable temperatures while E. coli, Salomonella and V. parahemolyticus were not at an acceptable temperature. Amongst the 21 Ready-to-eat (RTE) samples tested, L. monocytogenes was detected in 4 samples and none of the samples tested positive for S. aureus. In conclusion, this study illustrates the risks associated with online purchase of foods.
Microchaetus stuckenbergi Plisko 1991
Creators: name: Jadwiga Danuta Plisko
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Microchaetus
Microchaetus stuckenbergi

description: Microchaetus stuckenbergi Plisko, 1991
Microchaetus stuckenbergi: Plisko 1991 b: 294; Reynolds & Cook 1993: 21; Plisko 2003: 281.
This species is known only from its type locality in Stutterheim district, Eastern Cape.
description: Published as part of Jadwiga Danuta Plisko, 2006, A systematic reassessment of the genus Microchaetus Rapp, 1849: its amended definition, reinstatement of Geogenia Kinberg, 1867, and erection of a new genus Kazimierzus (Oligochaeta: Microchaetidae), pp. 31-56 in African Invertebrates 47 (1) on page 39, DOI: 10.5281/zenodo.160162
Virtually there
Creators: name: Wojenski, Carrie Louise Prior
Publisher: name: No Publisher Supplied
Year: 2014

description: As more guided study abroad interventions move online and into a collaborative format, it is important to not only examine the influence of students’ social interactions as related to their intercultural development and experiences in the interventions, but also understand which variables influenced the success of an intervention.  The purpose of this study was to identify factors that influenced students’ intercultural development and experiences in a collaborative online international learning pre-departure study abroad intervention.  To explore these questions I designed a collaborative online international learning intervention for pre-departure study abroad students.     Pre-departure U.S. study abroad students and international students coming to study abroad in the U.S. attended an online, collaborative seminar together over the course of six weeks in the fall and five weeks in the spring.  Garrison et al.’s (2000) Community of Inquiry model influenced the seminar design and data analysis.  A mixed-methods approach was used to gather data needed to study the intervention outcomes.  Data was obtained from: (1) a needs assessment; (2) pre and post IDI® scores from intervention and comparison groups; (3) focus groups; and (4) online discussions.  The three forms of data analysis used in this study, the IDI®, Community of Inquiry framework, and phenomenological review of participants’ text, provided a layered understanding of the research questions.  Data analysis suggested that designing and sustaining a successful Community of Inquiry, as well as a successful online collaborative learning environment, is not without its challenges.  This research demonstrated several technical and social challenges of building a Community of Inquiry and how a redesign of an intervention can influence outcomes.  Several challenges of collaborative learning and creating online communities identified in Computer-supported collaborative learning research were also apparent in this study.  Overall, this study underscored several variables that influence learning outcomes and experiences within a collaborative online international learning intervention.
Additional file 1: Table S1. of Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology
Creators: name: Matthews, Daragh
name: Diskin, Michael
name: Kenny, David
name: Creevey, Christopher
name: Keogh, Kate
name: Sinead Waters
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Description: Differentially expressed annotated genes between restricted anovulatory (RA) and control (C) groups. (DOCX 27Â kb)
Amphilophus sagittae Stauffer & McKaye 2002
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Cichlidae
Amphilophus
Amphilophus sagittae

description: Amphilophus sagittae Stauffer & McKaye 2002. Xiloán Arrow Cichlid; Mojarra Flecha de Xiloá
Vouchers: (other collections) PSU 82 (5), 3383 (2), 3386 (5) and 3386.1 (1). Distribution: Central America; endemic to the Lago Xiloá, Nicaragua; (Nicaragua) LN (Atlantic); 45– 45 masl; Sec, Pot. Occurrence and conservation status: Nat, End; VU D2 (2020), population trend stable. Literature: Stauffer & McKaye (2002: 12; original description), Stauffer et al. (2008: 117; comparative morphological data and information on distribution) and Recknagel et al. (2013: 209; comparative morphological data, including an identification key, and information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 50, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Glossodrilus kalmari Zicsi 1995
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Glossodrilus
Glossodrilus kalmari

description: Glossodrilus kalmari Zicsi, 1995
Glossodrilus kalmari Zicsi, 1995a Opusc. Zool. (Budapest) 27–28: 101.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 20, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Environmental factors and Google Docs use in Monmouth County middle schools
Creators: name: Wisnicki, Stephanie Kraft
Publisher: name: No Publisher Supplied
Year: 2014

description: When the Soviet Union launched Sputnik in 195&, it forced Americans to examine the state of science and technology at home.  Almost ten years later in 1983, the A Nation at Risk Report showed that schools were still failing in many areas including technology.  The No Child Left Behind Report released in the early 2000s confirmed that educational technology was still not meeting expectations.  Today, even minimum wage jobs require students to be proficient in the use of technology, and yet research indicates that technology in schools is used mostly for low level applications (administrative purposes, word processing, drill and kill activities, etc.).  The burning question is why have new technologies not diffused effectively through schools?    This study was designed to use diffusion theory to explain variation in use of Google Docs in Monmouth County, New Jersey.  It examined such environmental factors as communication channels, time, class size, computer access, decision method, and method of learning.  The data was collected using an on-line survey and 35 of the 53 middle schools in Monmouth County, New Jersey participated.  Fifty-five percent of the teachers in participating schools completed the survey.  Regression analysis was used to examine the data and the results demonstrated that time and collective decision method were statistically significant factors in determining teachers’ level of use of Google Docs.  When results from this study were combined with results from Tetreault’s work (in press), findings indicated that personal characteristics of teachers are more important than environmental factors.
Additional file 1: Table S1. of Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing
Creators: name: Soundararajan Krishnaswamy
name: Mohammed, Abdul
name: Gyanendra Tripathi
name: Alokail, Majed
name: Al-Daghri, Nasser
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Summary of splice variations identified in lung cancer cell lines. (DOCX 14 kb)
In the middle
Creators: name: Winkler, Matthew J.
Publisher: name: No Publisher Supplied
Year: 2014

description: The purpose of this qualitative study is to examine the pre-college factors, attitudes, and experiences of black men who joined traditionally white fraternities (TWFs) at large public predominantly white institutions (PWIs) over approximately the past four decades. These factors, with special emphasis on issues of identity, self- and group-esteem, and group salience when the individual’s environment changes, will be examined through the theoretical lens of Social Identity Theory.    An integrated set of qualitative methods was used to gather data. Participants were asked to complete a brief online demographic survey, were provided an opportunity to journal about their experiences, engaged in a semi-structured interview with the primary researcher, and were asked follow up questions where necessary.   Participants in this study de-emphasized their race as a factor in their identity and distanced themselves from a race-based fictive kinship due to both internal beliefs and external messages regarding negative stereotypes of blacks and black culture.  Participants reported immersion in predominantly white social and academic experiences and environments, a comparative identification with white peers over blacks while maintaining a tenuous fictive kinship, and that membership in a traditionally white fraternity was consistent with their academic and social attitudes and priorities, while also acknowledging that full acceptance in white culture was elusive.  Ultimately participants found themselves "in the middle;" navigating both worlds; not always fully accepted by whites while feeling disconnected from the views and attitudes of other blacks.
Additional file 2: Table S2. of Incidence of dengue and chikungunya viruses in mosquitoes and human patients in border provinces of Vietnam
Creators: name: Thi, Kim Pham
name: Briant, Laurence
name: Gavotte, Laurent
name: Labbe, Pierrick
name: Perriat-Sanguinet, Marco
name: Cornillot, Emmanuel
name: Vu, Trong
name: Nguyen, Thi
name: Tran, Vu
name: Nguyen, Van Soai
name: Devaux, Christian
name: Afelt, Aneta
name: Tran, Chi
name: Phan, Thi
name: Tran, Nhu
name: Frutos, Roger
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Mosquito cox1 sequences (DOCX 29 kb)
Microchaetus vernoni Plisko 1992
Creators: name: Jadwiga Danuta Plisko
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Microchaetus
Microchaetus vernoni

description: Microchaetus vernoni Plisko, 1992
Microchaetus vernoni: Plisko 1992: 349; Reynolds & Cook 1993: 22; Plisko 1998: 292; 2003: 292.
The species is known from numerous sites in Vernon Crookes Nature Reserve, KwaZulu- Natal.
description: Published as part of Jadwiga Danuta Plisko, 2006, A systematic reassessment of the genus Microchaetus Rapp, 1849: its amended definition, reinstatement of Geogenia Kinberg, 1867, and erection of a new genus Kazimierzus (Oligochaeta: Microchaetidae), pp. 31-56 in African Invertebrates 47 (1) on page 39, DOI: 10.5281/zenodo.160162
Understanding Natural Killer Cell Control of HIV Infection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Natural killer (NK) cells are innate lymphocyte responders that rapidly and robustly kill HIV-infected cells. They show great promise in establishing early control of infection in a vaccine or therapeutic setting where adaptive immune responses have proven to be too little and too late. Before this response can be elicited in a vaccine or therapeutic setting, NK cell recognition of HIV-infected cells must be understood at a detailed level. However, NK cells are a highly heterogeneous cell population, capable of a vast variety of functions and possessing a complex mosaic of surface receptors. The limits of fluorescence cytometry have prevented the simultaneous examination of all of these traits. To address this question, we propose the use of a novel technology, Cytometry by Time-Of-Flight (CyTOF). CyTOF uses rare metal isotope-labeled rather than traditional fluorophore-conjugated antibodies, with detection via mass spectrometry. Because it is not subject to spectral constraints, CyTOF can detect up to 40 cellular markers simultaneously, a considerable advance from the traditional fluorescence cytometry limit of 12-18. We have designed and validated a panel of antibodies for CyTOF to measure NK cell phenotype, and propose to add additional antibodies to measure NK cell functions during killing of HIV-infected cells. We will use this panel in conjunction with an established in vitro viral suppression assay, in which NK cells from healthy donors recognize and kill autologous HIV-infected CD4+ T cells. The highly parametric, deep profiling capabilities of CyTOF, applied to this specific, controlled interrogation of anti-HIV NK cell function, will allow us to gain profound insight into which NK cells are actively recognizing and killing HIV-infected cells. Results will be analyzed using a variety of complementary statistical techniques. Once this analysis has defined specific subsets of NK cells that appear to be involved in killing HIV-infected cells, we will complement these findings using in vitro functional assays to define precisely how the NK cells are recognizing and killing HIV-infected cells. We will use assays that classically examine single receptors or functions, but can be adapted to simultaneously interrogate multiple receptors or functions in a combinatorial manner. By combining the novelty of CyTOF with the reliability of established techniques, our innovative approach aims to understand which NK cell subsets to prime and which functions to stimulate in order to purposefully elicit an anti-HIV response in a vaccine or therapeutic setting. Our findings will therefore inform the development of innovative new approaches to vaccination to protect Californians from HIV.
Personal-level factors and Google Docs use in Monmouth County middle schools
Creators: name: Tetreault, Steven G.
Publisher: name: No Publisher Supplied
Year: 2014

description: Technology is essential in both personal and professional lives. Also, digital assessments, such as those being implemented as part of the Partnership for Assessment of Readiness for College and Careers (PARCC), will soon be instituted; these require students to utilize computer technology in order to complete the assessment. Therefore, it is imperative that administrators be aware of factors associated with increased frequency and complexity of technology use in teachers’ classrooms. This study examined the factors associated with the diffusion and implementation of a technological innovation (Google Docs) through schools/districts in Monmouth County, NJ.     An online survey provided quantitative data about teachers’ personal-professional characteristics and the frequency and complexity of respondents’ uses of Google Docs. Data was collected from 35 of the 53 schools in Monmouth County; 45% of the surveyed population provided viable responses. Linear regression determined which factors had a statistically significant association with the dependent variable “Google Docs Usage Score” (GDUS), a measure of frequency and complexity of Google Docs use. Independent variables culled from the literature were decision method (optional, collective, or authority); innovator type (innovator, early adopter, early majority, late majority, laggard); and the following personal characteristics: years of teaching experience; subject area taught; grade levels taught; number of types of technology used personally; number of types of technology used professionally; and technological, pedagogical, and content knowledge (TPACK) score (Mishra & Koehler, 2003).     This study determined there was a statistically significant association between the GDUS and the following variables: optional decision method; innovator, early adopter, and early majority innovator types; the subject areas Mathematics and Visual and/or Performing Arts; the number of types of technology used professionally; and TPACK score. These findings provide administrators with specific factors to consider when encouraging diffusion of a technological innovation such as Google Docs into a school. Combined with research by Wisnicki (2014), it was found that personal factors have a larger impact on GDUS than do environmental factors.     This study builds on the diffusion work of Rogers (2003) and the Concerns-Based Adoption Model of Hall, Wallace, & Dosset (19&3), and adds clarity to the literature on diffusion of educational technology within schools. This study also provides a new theoretical construct for examining levels of use of Google Docs, which could potentially be expanded to act as a measurement for other types of educational technology.
Pharmacological Modulation of PP2A Activity in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Dysregulated enzymatic pathways in breast cancer cells can be exploited as biomarkers and therapeutic targets. Consequently, the discovery and biochemical understanding of these pathways remains an important, yet challenging goal for breast cancer researchers. Mounting evidence has implicated the inactivation of protein phosphatase 2A (PP2A) as a critical step malignant transformation, but the molecular mechanisms of inactivation are not yet understood. One enzyme thought to contribute to the deactivation of PP2A is protein methylesterase-1 (PME-1), a pro-tumorigenic serine hydrolase that removes an activating post-translational methylation on the C-terminus of PP2A. These results suggest that the activation of PP2A by inhibition of PME-1 may represent a novel strategy to combat breast cancer.

 Previous research efforts in the Cravatt (mentor’s) laboratory have utilized a proteomics technology, called based protein profiling (ABPP), to discover the first selective PME-1 inhibitor. We are therefore in a unique position to study the enigmatic tumor suppressor PP2A through the use of the first pharmacological tool that specifically affects its regulation. In this project, we plan to use quantitative mass spectrometric methods to globally profile changes in cellular phosphorylation events in response to inhibitor treatment. In addition, we will genetically engineer breast cancer cell lines using shRNA technology to constitutively diminish PME-1 expression and perform similar analyses on these cell lines. We will then investigate the relationships of these events to breast cancer cell growth and malignancy.

 In the future, we plan to examine PME-1 activity and phosphopeptide signatures in primary human breast tumors as part of our ongoing, NIH-funded collaboration with Stefanie Jeffrey at Stanford Medical School. Ultimately, we hope that this research could potentially lead to new diagnostic markers and therapeutic targets for breast cancer.