cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effect of menstrual phase on fear extinction learning and recall
Creators: name: McKay, CL
Publisher: name: University Of Tasmania
Year: 2023

description: Females are twice more likely to develop anxiety disorders as males. One mechanism believed to underlie the development and maintenance of anxiety disorders is impaired fear extinction. Recent studies have considered menstrual phase as a factor that distinguishes males from females in fear extinction recall. The aim of the study was to replicate previous findings and investigate the independent effects of estrogen and progesterone on fear extinction recall. Sixteen males and 29 females (13 in the early-follicular phase, 16 in the mid-luteal phase) were tested in a two-day fear acquisition and extinction task and provided a saliva sample to assess hormonal levels. Skin conductance response was used as the dependent variable in the fear acquisition task. No significant differences were found between mid-luteal females, early follicular females and males during fear acquisition and extinction learning however, early follicular females demonstrated significantly lower fear extinction recall (higher fear recovery) than mid-luteal females. The findings suggest that the mid-luteal phase, with high estrogen and progesterone, may facilitate fear extinction recall in females. This outcome supports the delivery of treatments for some anxiety disorders based on fear extinction, such as exposure therapy, to female clients during the mid-luteal phase of the menstrual cycle.
Риторика как социально-культурное явление
Creators: name: Архарова Л.В.
Publisher: name: Философская школа
Year: 2019
Subjects: РИТОРИКА
РИТОРИЧЕСКИЙ ИДЕАЛ
ОСНОВНЫЕ ПОНЯТИЯ РИТОРИКИ
КУЛЬТУРА РЕЧИ
ЛОГИКА
ЭТИКА
ПРИНЦИПЫ МЫШЛЕНИЯ
СОЦИАЛЬНО ЗНАЧИМАЯ РЕЧЬ
РЕЧЕВОЕ ВОСПИТАНИЕ
РЕЧЕВОЕ ВОЗДЕЙСТВИЕ

description: Статья посвящена риторике как социальному и культурному явлению. Риторика долгие десятилетия не преподавалась в нашей стране, поэтому многие испытывают трудности с выражением своих мыслей. Необходимо исправлять ситуацию, и не только с запущенной риторикой, но и тесно связанными с ней культурой речи, логикой, этикой. Язык, как сущностное явление, и такие надстроечные явления, как культура речи, риторика и т.д., необходимы, прежде всего, не как средство общения, а как инструмент мышления. Взгляд на риторику лишь как на красноречие умаляет её роль в развитии личности. Речь становится социально значимой, если способствует изменениям в общественном сознании, влияет на результаты общественной деятельности. Рассматривается необходимость широкой популяризации риторики и культуры речи в современном обществе. Предлагается издавать риторику в удобных форматах, например, брошюры, листовки. Изучение риторики невозможно без ознакомления с её основными категориями, с этой целью были составлены таблицы, освещающие основы риторики и, тесно связанные с нею, логики и культуры речи.
Additional file 1 of Molecular phylogeny and phylogeography of the freshwater-fish genus Pethia (Teleostei: Cyprinidae) in Sri Lanka
Creators: name: Sudasinghe, Hiranya
name: Ranasinghe, Tharindu
name: Herath, Jayampathi
name: Wijesooriya, Kumudu
name: Pethiyagoda, Rohan
name: Rüber, Lukas
name: Meegaskumbura, Madhava
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Additional file 1: Fig. S1. Molecular phylogenetic relationships of Pethia, based on Bayesian inference of the cytb (1082 bp) data set. Asterisks (*) above and below nodes represent ≥ 95% Bayesian posterior probabilities and ML bootstrap values, respectively. Scale bar represents number of changes per site. Node support below 50 is not labeled. Fig. S2. Molecular phylogenetic relationships of Pethia, based on Bayesian inference of the rag1 (1490 bp) data set. Asterisks (*) above and below nodes represent ≥ 95% Bayesian posterior probabilities and ML bootstrap values, respectively. Scale bar represents number of changes per site. Node support below 50 is not labeled. Table S1. Valid species of Pethia, with their type localities, distinguishing characters and distribution. Table S2. The comparative genetic dataset representative of Smiliogastrinae and outgroups downloaded from GenBank. Table S3. Nucleotide substitution models and the partitions used in the phylogenetic analyses. Table S4. Specimens of Pethia examined for the morphological analysis. LK, Sri Lanka; IND, India. Table S5. Intraspecific uncorrected pairwise cytb genetic distances for species of Pethia in Sri Lanka. Table S6. Genetic diversity, based on cytb and rag1, in Sri Lankan species of Pethia. Number of sequences (N), number of haplotypes (h), polymorphic sites (S), parsimony-informative sites (P), nucleotide diversity (π), haplotype diversity (Hd). None of the neutrality tests were statistically significant. Table S7. Component loadings in the principal component analysis of the size-adjusted morphometric measurements of species of Pethia in Sri Lanka. Table S8. Proportional morphometric data for the species of Pethia in Sri Lanka. Table S9. Frequency distribution of selected meristic data in the Sri Lankan species of Pethia examined in the present study. Table S10. Proportional morphometric data for Pethia bandula, P. nigrofasciata (excluding Attanagalu populations), and P. cf. nigrofasciata (Attanagalu population). Table S11. Proportional morphometric data for Pethia reval, P. cumingii (Bentara and Gin populations), and P. cf. cumingii (Kalu population) in Sri Lanka.
The infrared emission of ultraviolet selected galaxies from z = 0 to z=1
Creators: name: Buat, V.
name: Takeuchi, T. T.
name: Burgarella, D.
name: Giovannoli, E.
name: Murata, K. L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We select galaxies in UV rest-frame at z=0, z~0.7 and z~1 together with a sample of LBGs at z~1, the samples are built in order to sample the same range of luminosity at any redshift. The evolution of the IR and UV luminosities with z is analysed for individual galaxies as well as in terms of luminosity functions. The L_IR/L_UV ratio is used to measure dust attenuation. This ratio does not exhibit a strong evolution with z for the bulk of our sample galaxies but some trends are found for galaxies with a strong dust attenuation and for UV luminous sources: galaxies with L_IR/L_UV>10 are more frequent at z>0 than at z=0 and the largest values of L_IR/L_UV are found for UV faint objects; conversely the most luminous galaxies of our samples (L_UV> 2 10^{10} L_sun$), detected at z=1, exhibit a lower dust attenuation than the fainter ones. L_IR/L_UV increases with the K rest-frame luminosity of the galaxies at all the redshifts considered and shows a residual anti-correlation with L_UV. The most massive and UV luminous galaxies exhibit quite large specific star formation rates. LBGs exhibit systematically lower dust attenuation than UV selected galaxies of same luminosity but similar specific star formation rates. The analysis of the UV+IR luminosity functions leads to the conclusion that up to z = 1 most of the star formation activity of UV selected galaxies is emitted in IR. Whereas we are able to retrieve all the star formation from our UV selection at z=0.7, at z = 1 we miss a large fraction of galaxies more luminous than ~ 10^{11} L_sun. The effect is found larger for Lyman Break Galaxies.
description: 13 pages. accepted for publication (Astronomy and Astrophysics)
РЕЦЕНЗИЯ на монографию В.В. Яровенко, Н.Н. Китаева, Р.Г. Ардашева «Дактилоскопическое и дерматоглифическое исследование папиллярных узоров серийных убийц»
Creators: name: Владимир Степанович ИШИГЕЕВ
Publisher: name: Закон и право
Year: 2020
Subjects: дактилоскопия
криминалистическая дерматоглифика
серийные убийцы
выявление правонарушителей

description: Рецензируемая монография является первой в России и странах ближнего зарубежья работой, содержащей сведения о дерматоглифической характеристике 95 известных серийных убийц. Описание деяний правонарушителей, данное на основе изучения уголовных дел, в совокупности с репродукциями дактилоскопических карт обвиняемых представляет неоценимый эмпирический материал для исследователей. Монография может быть использована в научно-исследовательской, экспертной и педагогической деятельности.
Spontaneous Symmetry Breaking in General Relativity. Brane World Concept
Creators: name: Meierovich, Boris E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Gravitational properties of a hedge-hog type topological defect in two extra dimensions are considered in General Relativity employing a vector as the order parameter. The developed macroscopic theory of phase transitions with spontaneous symmetry breaking is applied to the analysis of possible "thick" brane structures. The previous considerations were done using the order parameter in the form of a multiplet in a target space of scalar fields. The difference of these two approaches is analyzed and demonstrated in detail. There are two different symmetries of regular solutions of Einstein equations for a hedgehog type vector order parameter. Both solutions are analyzed in parallel analytically and numerically. Regular configurations in cases of vector order parameter have one more free parameter in comparison with the scalar multiplet solutions. It is shown that the existence of a negative cosmological constant is sufficient for the spontaneous symmetry breaking of the initially plain bulk. Regular configurations have a growing gravitational potential and are able to trap the matter to the brane. Among others there are solutions with the gravitational potential having several points of minimum. Identical in the uniform bulk spin-less particles, being trapped within separate points of minimum, acquire different masses and appear to an observer within the brane as different particles with integer spins.
description: 29 pages, 12 figures
On the Veldkamp Space of GQ(4, 2)
Creators: name: Saniga, Metod
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Algebraic Geometry (math.AG)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The Veldkamp space, in the sense of Buekenhout and Cohen, of the generalized quadrangle GQ(4, 2) is shown not to be a (partial) linear space by simply giving several examples of Veldkamp lines (V-lines) having two or even three Veldkamp points (V-points) in common. Alongside the ordinary V-lines of size five, one also finds V-lines of cardinality three and two. There, however, exists a subspace of the Veldkamp space isomorphic to PG(3, 4) having 45 perps and 40 plane ovoids as its 85 V-points, with its 357 V-lines being of four distinct types. A V-line of the first type consists of five perps on a common line (altogether 27 of them), the second type features three perps and two ovoids sharing a tricentric triad (240 members), whilst the third and fourth type each comprises a perp and four ovoids in the rosette centered at the (common) center of the perp (90). It is also pointed out that 160 non-plane ovoids (tripods) fall into two distinct orbits -- of sizes 40 and 120 -- with respect to the stabilizer group of a copy of GQ(2, 2); a tripod of the first/second orbit sharing with the GQ(2, 2) a tricentric/unicentric triad, respectively. Finally, three remarkable subconfigurations of V-lines represented by fans of ovoids through a fixed ovoid are examined in some detail.
description: 6 pages, 7 figures; v2 - slightly polished, subsection on fans of ovoids and three figures added
The Effect of Private Schooling on Learning Outcomes in South Asia and East Africa: A Within-Family Approach
Creators: name: Gruijters, Rob J
name: Rose, Pauline
name: Alcott, Benjamin
Publisher: name: Zenodo
Year: 2020
Subjects: Private schools
Educational inequality
Family fixed effect
Learning crisis
India
Pakistan
Kenya
Uganda

description: A contentious debate in academic as well as policy circles relates to the growth in private schooling in Sub-Saharan Africa and other low-income regions. While proponents highlight the superior learning outcomes of pupils in private schools, others have argued that this is merely a reflection of the more advantaged family background of private school pupils, rather than an effect of private schooling itself. We contribute to this debate by providing estimates derived from household fixed effect models, which control for any observed or unobserved differences between government and private school pupils at the household level. We argue that these can be interpreted as an upper bound estimate of the effect of private schooling on learning. We rely on large-scale, comparable household survey data from Kenya, Uganda, India and Pakistan, focusing on children enrolled in grade 2 to 6 of primary school. Private school attendance ranges from 12% in Kenya to 33% in rural India, with substantial within-household variation. Preliminary findings show that controlling for family background almost eliminates the positive effect of private schooling in rural Pakistan and reduces it by around half in rural India, Kenya and Uganda, to about a quarter of a standard deviation. Subgroup analyses show that the effect of private schooling does not differ substantially between high- and low-SES families. We discuss implications for educational policy.
Иерусалимские свитки: исторические фантазии на евангельские сюжеты части вторая и третья
Creators: name: Пекелис М.А.
Publisher: name: Философская школа
Year: 2019
Subjects: ИИСУС ХРИСТОС
ЦАРЬ ИРОД
ВОЛХВЫ
ЛАЗАРЬ ЧЕТВЕРОДНЕВНЫЙ
АПОСТОЛЫ
ИЕРУСАЛИМ
РИМ
БОГ
ИУДЕЯ
ХРАМ

description: Евангельские и библейские сюжеты уже на протяжении многих столетий составляют значительную часть мирового культурного наследия. В настоящий момент в мире несколько миллиардов христиан, принадлежащих к различным христианским конфессиям. В настоящей одновременно философской и поэтической работе предлагается некая философско-историческая реставрация событий, происходивших более двух тысячелетий тому назад. Эти фрагменты стихотворного философского текста являются продолжением первой части «Иерусалимских свитков», опубликованных в первом номере журнала «Философская школа» за 2017 год.
Application value of multi-gene mutation detection in pediatric PTC
Creators: name: 闫娜(Na Yan)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multiisolate
Medical

description: Thyroid cancer rarely occurs in children and adolescents. Molecular markers such as BRAF, RAS, and RET/PTC have been widely used in adult PTC. It is currently unclear whether these molecular markers have equivalent potential for application in pediatric patients. This study aims to explore the potential utility of a multi-gene conjoint analysis based on next-generation targeted sequencing for pediatric papillary thyroid carcinoma (PTC).
Воображение как катализатор развития науки и искусства
Creators: name: Антипов С.С.
Publisher: name: Философская школа
Year: 2019
Subjects: ФИЛОСОФСКАЯ АНТРОПОЛОГИЯ
ВООБРАЖЕНИЕ
ФАНТАЗИЯ
ТВОРЧЕСКОЕ ВООБРАЖЕНИЕ
ОБРАЗ
ИДЕЯ
ВИЗУАЛИЗАЦИЯ
НАУКА
ИСКУССТВО
ГЕНИАЛЬНОСТЬ

description: Автор продолжает исследование воображения, как одного из важнейших свойств человеческого бытия (см.: Философская школа. 2018. №5). Даётся историко-философская ретроспектива воображения в трудах философов от античности до наших дней. Проводится мысль о том, что виртуальная среда, создаваемая во многом благодаря интеграции образов воображения огромных масс современных людей, преобразует реальность, одновременно, внося изменения в самою природу человека. При этом воображение является важнейшим катализатором и питательной средой науки и искусства. Перспективы настоящего исследования автор видит в необходимости рассмотреть понятие «воображение» в системе следующих сопутствующих понятий «творческий дар», «вдохновение», «интуиция», «озарение», «апперцепция», «гениальность».
Geometric formality of homogeneous spaces and of biquotients
Creators: name: Kotschick, D.
name: Terzic, S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 53C25, 53C30

description: We provide examples of homogeneous spaces which are neither symmetric spaces nor real cohomology spheres, yet have the property that every invariant metric is geometrically formal. We also extend the known obstructions to geometric formality to some new classes of homogeneous spaces and of biquotients, and to certain sphere bundles.
description: 15 pages
Super media world : an archaeology of convergence and exchange between physical and digital spaces
Creators: name: Dorloff, JF
Publisher: name: University Of Tasmania
Year: 2023

description: Super Media World has been an exploration of the spaces that exist around, within, and between screen technologies. Investigating the physical locations inhabited by screen and viewer, illusory time-spaces constructed by the spectacles of cinema and TV, and the online site-spaces created by digital media, I have collected and produced imagery, footage, and objects from these spaces, using them to create artworks that explore potential interactions and points of convergence between these realms. With reference to modes of collection, manipulation, archiving, and reproduction, this project has examined the flexible, convergent nature of screen spaces past and present. Following a method of production based on the media archaeologies of Erkki Huhtamo and Jussi Parikka, I researched the layers of technological history that have shaped the current media environment, at once identifying, expanding, and augmenting these strata through my intervention. This central process became a way of tracing, crafting, and subverting moments of intersection between physical and digital spaces of the screen, generating new layers, new archaeologies. With reference to the philosophies and practices of Walter Benjamin, Michel Foucault, and Soda_Jerk, amongst others, this project has considered the fluidity of spaces, reflecting on the relationship between advances in techniques of viewing and fluctuations in perception. With an awareness that any concept of the relationship between spaces is in a state of constant flux, the aim, and outcome, of this project has been to mediate, recreate, and reflect on the potential alteration of visible spaces through artistic intervention using screen-based media.
Упразднение работы как философская проблема: к истории вопроса в ХХ веке
Creators: name: Шулико Г.А.
Publisher: name: Философская школа
Year: 2019
Subjects: ТРУД
РАБОТА
ЧЕЛОВЕК
СВОБОДА
ГУМАНИЗМ
НЕОМАРКСИЗМ
ПОСТСТРУКТУРАЛИЗМ
КРИТИЧЕСКАЯ ТЕОРИЯ
НОВЫЙ ДУХ КАПИТАЛИЗМА
ПОСТГУМАНИЗМ

description: Критика работы является одним из самых модных направлений в современной социальной и философской мысли. В данной статье предпринимается попытка сделать общий исторический очерк по данной теме за последние 80 лет. В новейшей истории становления радикальной критики работы можно выделить три основных периода. Первый, гуманистический, когда упразднение труда рассматривалось неомарксистами в качестве необходимого условия освобождения человека. Второй, антигуманистический, когда концептуальная критика перестала ассоциировать «смерть труда» со свободой и природой человека, подставив эти понятия под сомнения. Наконец нынешний, неогуманистический или постгуманистический период, когда социальные мыслители возвращаются ко многим содержаниям гуманистической критики труда, но при этом в контексте тех социальных и теоретических реалий, которые пришли в свое время вместе с теоретическим антигуманизмом. Научная новизна исследования состоит в попытке применить концепцию нового духа капитализма (Л. Болтански, Э. Кьяпелло) к проблеме критики работы. Критически относящийся к любому субстанционализму в описании человека, философский антигуманизм предстает концептуальной основой «третьего духа» капитализма. Кроме того, в статье заявлена и обоснована точка зрения на критику работы как на умеренную критику труда.
О сопротивлении: беседа с Жан-Франсуа Лиотаром перевод с английского Е. Г. Рудневой
Creators: name: Бенвенуто С.
Publisher: name: Философская школа
Year: 2019
Subjects: ПОСТМОДЕРНИЗМ
ФИЛОСОФИЯ ПОДОЗРЕНИЯ
СОПРОТИВЛЕНИЕ
МЕТАФИЗИКА
ПСИХОАНАЛИЗ
ЗАЩИТА
БЕССОЗНАТЕЛЬНОЕ
ПОЛИТИКА
СОВРЕМЕННОЕ ИСКУССТВО
СИСТЕМА

description: Опубликованная в «Журнале Европейского психоанализа» [Journal of European Psychoanalysis] беседа с Жан-Франсуа Лиотаром была проведена Серджио Бенвенуто и проясняет некоторые философские взгляды этого французского теоретика постмодернизма. Основные обсуждаемые вопросы это понятия защиты и сопротивления, которые Лиотар применяет к таким разным областям, как эстетика, политика и постмодернистская идеология. Лиотар подводит итог своей интеллектуальной деятельности, начиная с левых движений 1960-х годов и вплоть до «меланхолической» констатации факта об отсутствии альтернативы существующей Системе, к чему он пришел в последние годы жизни.
Characterisation of flowmotion in healthy controls and type 2 diabetes
Creators: name: Blackwood, SJ
Publisher: name: University Of Tasmania
Year: 2023

description: Flowmotion, the rhythmic oscillation of blood flow across a tissue, optimises nutrient delivery at rest and during states of increased metabolic demand. Five known factors influence flowmotion patterns across a tissue, each distinguishable by their rate of input; cardiac, respiratory, myogenic, neurogenic and endothelial components. In disease states such as type 2 diabetes (T2D), flowmotion is thought to be altered and may contribute to dysregulated metabolism. The aim of this thesis was to characterise flowmotion in healthy controls and T2D participants. Flowmotion was investigated in healthy controls and T2D participants at rest, and following endogenous insulin release in response to a 50g oral glucose challenge (OGC). The effect of a resistance training (RT) intervention in T2D participants was also assessed. Total blood flow to the forearm was measured using 2D-ultrasound and skeletal muscle perfusion was measured with contrast enhanced ultrasound (CEU). Microvascular blood flow in the skin and subcutaneous tissue (skin+SC) of the forearm was examined using a combined Laser Doppler Flowmetry (LDF) and tissue oxygenation probe. Spectral analysis (wavelet transformation) was performed on the data to characterise the individual contributions of the five factors known to influence flowmotion. Type 2 diabetics exhibited differences in total blood flow, skin+SC LDF flux and skin+SC flowmotion compared to healthy controls at rest. Flowmotion was altered in response to the OGC in healthy controls, without changes in total flow and skin+SC LDF flux. In contrast, flowmotion and skin+SC LDF flux were unaltered in response to OGC in T2D, while total blood flow to the forearm increased. In the T2D group, a 6-week RT intervention partially restored skin+SC flowmotion. In response to OGC skeletal muscle microvascular perfusion was reduced in healthy controls, but not in T2D participants. In contrast, skin+SC microvascular perfusion did not change in response to OGC in either group, indicating skin+SC flowmotion may not represent flowmotion in skeletal muscle. The CEU technique, used to determine skeletal muscle microvascular perfusion, was adapted to investigate flowmotion within skeletal muscle. In anaesthetised rats, skeletal muscle flowmotion patterns were measured with both the LDF and the newly adapted CEU techniques. An ˜í¬±-adrenoceptor antagonist, which inhibits the neurogenic component of flowmotion, was used to compare the two techniques. Both the LDF and CEU methods detected the inhibition. In addition, the CEU method enable identification of different flowmotion patterns within specific fibre types. In conclusion, these studies demonstrate dysfunction in blood flow and flowmotion in T2D. They also highlight a difference in skin+SC and skeletal muscle microvascular blood flow in response to OGC. The newly adapted CEU technique will allow more informative assessment of flowmotion in skeletal muscle, facilitating future research into its role in regulation of muscle metabolism.
Hydrosmittia Ferrington & Saether 2011
Creators: name: Namayandeh, Armin
name: Hudson, Patrick L.
name: Bogan, Daniel L.
name: Hudson, John P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Hydrosmittia

description: Hydrosmittia Ferrington & Saether, 2011
Hydrosmittia ruttneri (Strenzke & Thienemann, 1942) is the only species of Hydrosmittia recorded from Alaska. Ferrington & Saether (2011) reported on collecting adult and immature specimens from Happy Creek near Happy Valley Camp on the Kenai Peninsula in early July 1976. They also mentioned a specimen from Lake Nerka but provided no details. Most species in Hydrosmittia and related groups (i.e., Allocladius and Pseudosmittia) are considered semi-aquatic to terrestrial. However, H. ruttneri larva is truly aquatic, living on algal-covered rocks in lakes and rivers (Ferrington & Saether 2011).
description: Published as part of Namayandeh, Armin, Hudson, Patrick L., Bogan, Daniel L. & Hudson, John P., 2024, Chironomidae (Diptera: Insecta) of Alaska, USA, with descriptions of new species and a checklist, pp. 1-95 in Zootaxa 5511 (1) on page 61, DOI: 10.11646/zootaxa.5511.1.1, http://zenodo.org/record/13848177
Studies on the reverse antibiotic natural products, the nybomycins
Creators: name: Bardell-Cox, Oliver
Publisher: name: Imperial College London
Year: 2021

description: Antimicrobial resistance (AMR) is likely to be one of the greatest challenges faced by humanity and if nothing changes it is projected to kill one person every 5 seconds by 2050. Despite this, there are few new therapeutic options in development and so there is a need for new solutions to be identified. One new strategy is the reverse antibiotic approach originally published by Akamatsu and co-workers. Here treatment with the first antibiotic leads to resistance so a new antibiotic is needed. Resistance to the second antibiotic can only be achieved by a back-mutation thus re-sensitising the bacteria to the first antibiotic. The bacteria will be trapped in an ‘evolutionary loop’ where it will always be sensitive to either the first or second antibiotic. Work outlined in this thesis will look to investigate and develop one of the key series of antibiotics in the reverse antibiotic approach, the Nybomycin family of natural products. A new robust and scalable synthetic route that facilitated the synthesis of the best literature compound DNM-2, as well as novel analogues to probe the SAR, is reported. The whole cell inhibition of these compounds is reported as well as selected analogue’s enzymatic inhibition of the key biological targets. The ability of the series to inhibit Gram-negative bacteria was also explored and led to the discovery that the series is a substrate for efflux via the AcrAB/TolC efflux channel. However, the compounds are active in E. coli if TolC or AcrB is removed. After initial profiling, aqueous solubility was found to be the major hurdle in the development of the series. This was addressed using medicinal chemistry techniques as well as computational chemistry to aid in the design of novel analogues. This led to the discovery of 6DNM-2-L1A, the most potent and soluble analogue tested to date.
Measuring Dust Production in the Small Magellanic Cloud Core-Collapse Supernova Remnant 1E 0102.2-7219
Creators: name: Sandstrom, Karin M.
name: Bolatto, Alberto D.
name: Stanimirovic, Snezana
name: van Loon, Jacco
name: Smith, J. D. T.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present mid-infrared spectral mapping observations of the core-collapse supernova remnant 1E 0102.2-7219 in the Small Magellanic Cloud using the InfraRed Spectrograph (IRS) on the Spitzer Space Telescope. The remnant shows emission from fine structure transitions of neon and oxygen as well as continuum emission from dust. Comparison of the mid-IR dust emission with observations at x-ray, radio and optical wavelengths shows that the dust is associated with the supernova ejecta and is thus newly formed in the remnant. The spectrum of the newly formed dust is well reproduced by a model that includes 3x10^-3 solar masses of amorphous carbon dust at 70 K and 2x10^-5 solar masses of Mg2SiO4 (forsterite) at 145 K. Our observations place a lower limit on the amount of dust in the remnant since we are not sensitive to the cold dust in the unshocked ejecta. We compare our results to observations of other core-collapse supernovae and remnants, particularly Cas A where very similar spectral mapping observations have been carried out. We observe a a factor of ~10 less dust in E 0102 than seen in Cas A, although the amounts of amorphous carbon and forsterite are comparable.
description: submitted to ApJ
К вопросу о манифесте виртуального человека: к 200-летию со дня рождения Карла Маркса (English)
Creators: name: Пронин М.А.
Publisher: name: Философская школа
Year: 2019
Subjects: КАРЛ МАРКС
ФРИДРИХ ЭНГЕЛЬС
МАНИФЕСТ КОММУНИСТИЧЕСКОЙ ПАРТИИ
ВИРТУАЛЬНАЯ И ДОПОЛНЕННАЯ РЕАЛЬНОСТИ
ВИРТУАЛЬНЫЙ ЧЕЛОВЕК
МАНИФЕСТ ВИРТУАЛЬНОГО ЧЕЛОВЕКА
ВИРТУАЛИСТИКА
ОШИБКИ ПСИХОЛОГИЧЕСКОЙ ПРИРОДЫ
ФЕНОМЕН НЕ РАЗЛИЧЕНИЯ У ЧЕЛОВЕКА

description: Виртуальный человек выходит на авансцену мира. Пока это свершение находится в коллективном когнитивном бессознательном общества и коллективном когнитивном неосознаваемом науки мейнстрима, что затрудняет, если не делает невозможным, осмысление проблемных полей глобализации, цифровизации экономики, социальной сферы и жизни каждого человека во всей полноте проявлений их феноменов, результатов и эффектов, включая паразитные. И, как следствие, актуализирует потребность в глубинном философско-антропологическом, понимании скрытых процессов и их природы в современном мире, в социуме, в группе и в каждом индивидууме. Природная виртуальность человека способность человека переживать виртуальные психологические состояния и ошибаться, которую не замечают и возможности технологий виртуальной (virtual reality technologies), дополненной (augmented reality technologies) и замещающей реальности (substitutional reality technologies) далее VR, вводить человека в обман становятся фактором развития новой̆ эволюции человека. Феномен не различения ошибок восприятия, формирует новый̆ тип отношений человека с миром; технологии VR меняют способ производства и отношения человека с ними с новыми средствами производства. Теоретическая научная новизна настоящей работы состоит в аттракции привлечении внимания к тому, что «призрак Коммунизма» вновь бродит по миру: К. Маркс и Ф. Энгельс не могли предполагать как и в каком виде сбудется пророчество их Манифеста о том, что «на место старого буржуазного общества с его классами и классовыми противоположностями приходит ассоциация, в которой свободное развитие каждого является условием свободного развития всех». Ассоциации индивидов из «Манифеста коммунистической партии» преодолевают границы стран и континентов «виртуальными дорогами»; история неокоммунизма творится на наших глазах. Виртуальные человеки всех стран соединяйтесь!
Parton dynamics and hadronization from the sQGP
Creators: name: Cassing, W.
name: Bratkovskaya, E. L.
name: Xing, Y. -. Z.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The hadronization of an expanding partonic fireball is studied within the Parton-Hadron-Strings Dynamics (PHSD) approach which is based on a dynamical quasiparticle model (DQPM) matched to reproduce lattice QCD results in thermodynamic equilibrium. Apart from strong parton interactions the expansion and development of collective flow is found to be driven by strong gradients in the parton mean-fields. An analysis of the elliptic flow $v_2$ demonstrates a linear correlation with the spatial eccentricity $ε$ as in case of ideal hydrodynamics. The hadronization occurs by quark-antiquark fusion or 3 quark/3 antiquark recombination which is described by covariant transition rates. Since the dynamical quarks become very massive, the formed resonant 'pre-hadronic' color-dipole states ($q\bar{q}$ or $qqq$) are of high invariant mass, too, and sequentially decay to the groundstate meson and baryon octets increasing the total entropy. This solves the entropy problem in hadronization in a natural way. Hadronic particle ratios turn out to be in line with those from a grandcanonical partition function at temperature $T \approx 170$ MeV.
description: submitted to Prog. Part. Nucl. Phys
X-ray and optical study of the new SMC X-ray binary pulsar system SXP7.92 and its probable optical counterpart, AzV285
Creators: name: Coe, M. J.
name: Schurch, M.
name: McBride, V. A.
name: Corbet, R. H. D.
name: Townsend, L. J.
name: Udalski, A.
name: Galache, J. L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Optical and X-ray observations are presented here of a newly reported X-ray transient system in the Small Magellanic Cloud - SXP7.92. A detailed analysis of the X-ray data reveal a coherent period of 7.9s. A search through earlier X-ray observations of the SMC reveal a previously unknown earlier detection of this system. Follow-up X-ray observations identified a new transient source within the error circle of the previous observations. An optical counterpart, AzV285, is proposed which reveals clear evidence for a 36.8d binary period.
description: 7 pages. Accepted for publication in MNRAS
Swift and Fermi observations of the early afterglow of the short Gamma-Ray Burst 090510
Creators: name: De Pasquale, M.
name: Schady, P.
name: Kuin, N. P. M.
name: Page, M. J.
name: Curran, P. A.
name: Zane, S.
name: Oates, S. R.
name: Holland, S. T.
name: Breeveld, A. A.
name: Hoversten, E. A.
name: Chincarini, G.
name: Grupe, D.
name: Fermi/LAT
name: authorlist, Fermi/GBM collaborations. Minor changes in the
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the observations of GRB090510 performed by the Fermi Gamma-Ray Space Telescope and the Swift observatory. This is a bright, short burst that shows an extended emission detected in the GeV range. Furthermore, its optical emission initially rises, a feature so far observed only in long bursts, while the X-ray flux shows an initial shallow decrease, followed by a steeper decay. This exceptional behavior enables us to investigate the physical properties of the GRB outflow, poorly known in short bursts. We discuss internal shock and external shock models for the broadband energy emission of this object.
description: Comments: Submitted to ApJ Letters. Contact Authors: Massimiliano De Pasquale (mdp@mssl.ucl.ac.uk), Mathew Page (mjp@mssl.ucl.ac.uk), Kenji Toma (toma@astro.psu.edu), Veronique Pelassa (pelassa@lpta.in2p3.fr). Minor change in the authorlist
Breaking and restoring symmetries within the nuclear energy density functional method
Creators: name: Duguet, T.
name: Sadoudi, J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We review the notion of symmetry breaking and restoration within the frame of nuclear energy density functional methods. We focus on key differences between wave-function- and energy-functional-based methods. In particular, we point to difficulties to formulate the restoration of symmetries within the energy functional framework. The problems tackled recently in connection with particle-number restoration serve as a baseline to the present discussion. Reaching out to angular-momentum restoration, we identify an exact mathematical property of the energy density $E^{LM}(\vec{R})$ that could be used to constrain energy density functional kernels. Consequently, we suggest possible routes towards a better formulation of symmetry restorations within energy density functional methods.
description: 16 pages, 3 figures, contribution to the "Focus issue on Open Problems in Nuclear Structure", Journal of Physics G
Distribution, metabolism, and localisation of cyclohexanecarboxylic acid, a naphthenic acid in Phaseolus vulgaris L.
Creators: name: Padmanabhan, Usha
Publisher: name: University of British Columbia
Year: 2011

description: Naphthenic acids, obtained from crude petroleum, have been known for the past two decades, to act as plant growth stimulants. The present investigation deals with several aspects of the fate of cyclohexanecarboxylic acid (CHCA), a component of the naphthenic acid mixture, in bush bean plants, Phaseolus vulgaris L. cultivar "Top Crop" following application to the primary leaves. A foliar spray of 0.01 M CHCA applied to the primary leaves of 14-day old bush bean plants increased the vegetative and reproductive growths. The glucose conjugate of CHCA was the first metabolite to be formed (in 1/8 hr) in the leaves treated with labelled CHCA as a K salt (KCHC-7-¹⁴C). The aspartate conjugate of CHCA and an unknown metabolite 'Y’ were detected about an hour after treatment. These three metabolites were present in the plant until four weeks after treatment. No free CHCA was detected 8 hr after application. This suggests that the metabolites, rather than the free acid, were responsible for the growth stimulation observed. The metabolites of CHCA hence cannot be merely detoxication products. The major fraction of the ethanol soluble ¹⁴C activity remained in the treated primary leaves. The lowest amounts of activity were found in the fraction composed of buds, flowers and pods. This pattern of distribution of activity was observed at 1, 2, 3 and 4 weeks after application of KCHC-7-¹⁴C. The glucose and aspartate conjugates of CHCA and the unidentified compound 'Y’ were present in the plant at the times mentioned above. At the end of each week, an amount of activity equal to 0.4% or less of the total ethanol-soluble activity was found in ethanol-insoluble plant residues. CHCA was decarboxylated by bean plants. The ¹⁴CO₂ released during a period of seven days accounted for 33% of the activity absorbed. The distribution of the activity in the plant, following application of KCHC-7- ¹⁴C to primary leaves, involved both basipetal and acropetal movements. The basipetal movement occurred in the phloem and the acropetal, in the xylem and phloem. The translocation of CHCA was favoured by light. Evidences obtained suggest that energy in the form of ATP was required for translocation. In the dark, the provision of glucose favoured the translocation, perhaps by serving as a source of ATP via respiration. A supply of aspartate in the dark favoured the translocation slightly. The radioactivity from CHCA was localized in the chloroplasts of the cell. An ethanol extract of these organelles contained both glucose and aspartate conjugates of CHCA. It is suggested that the chloroplasts represent an important site of action of CHCA. The effects of the naphthenate mixture and the individual naphthenate, cyclohexanecarboxylate on growth show marked similarities. It is possible that the cyclohexanecarboxylic acid may be the chief growth promoting component of the naphthenic acid mixture.
The stress tensor in Thermodynamics and Statistical Mechanics
Creators: name: Rossi, Giancarlo
name: Testa, Massimo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We prove that the stress tensor, tau^{ab}, of a molecular system with arbitrary, short-range interactions can be point-wisely expressed as the functional derivative of the partition function with respect to the local deformation tensor. In this approach the set of components of tau^{ab} has a simple interpretation as the set of Lagrangian multipliers which need to be introduced to enforce the conditions relating point particle displacements to the body local deformation tensor. The question of the non-uniqueness of the formula for tau^{ab} is discussed.
description: 8 pages
Was ist eine Person?
Creators: name: Perler, Dominik
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: Leibniz
subject: Locke
subject: person
subject: substance
subject: identity
subject: rationalism
subject: principle of sufficient reason
subject: consciousness
subject: 100 Philosophie und Psychologie

description: Leibniz holds that we cannot give an account of the synchronic and diachronic identity of a person without appealing to a substance. This paper analyses his reasons for this anti-Lockean thesis. It first looks at his theory of substance, paying particular attention to his commitment to the Principle of Sufficient Reason: the existence of a well-ordered series of mental states cannot be sufficiently explained without reference to a substance. The paper then examines the distinction Leibniz draws between the substance as the “real person” and the “appearing person” that comes into existence through reflexive consciousness. It argues that there can be no appearing person without a real person and looks at the relationship between these two types of person. Leibniz’s distinction is still relevant because it shows that questions concerning the metaphysical constitution of a person need to be carefully distinguished from questions concerning the psychological construction of a personality.
Nonabelian plasma instabilities in Bjorken expansion
Creators: name: Rebhan, Anton
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Plasma instabilities are parametrically the dominant nonequilibrium dynamics of a weakly coupled quark-gluon plasma. In recent years the time evolution of the corresponding collective colour fields has been studied in stationary anisotropic situations. Here I report on recent numerical results on the time evolution of the most unstable modes in a longitudinally expanding plasma as they grow from small rapidity fluctuations to amplitudes where non-Abelian self-interactions become important.
description: 4 pages, 1 figure. Talk given at SEWM 2008, August 26-29, Amsterdam
Additional file 1 of A survey on Canadian pediatric hospital clinical/medical teaching unit implementation during the first and second wave of the COVID-19 pandemic
Creators: name: Tsang, Kara K.
name: Latchman, Andrew
name: Singhal, Nishma
name: Federici, Giuliana
name: Russell, Sandra
name: Irwin, Denise
name: Stevens, Robyn
name: McArthur, Andrew G.
name: Khan, Sarah
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Local and global properties of mixtures in one-dimensional systems. II. Exact results for the Kirkwood-Buff integral
Creators: name: Ben-Naim, Arieh
name: Santos, Andrés
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The Kirkwood-Buff integrals for two-component mixtures in one-dimensional systems are calculated directly. The results are applied to square-well particles and found to agree with those obtained by the inversion of the Kirkwood-Buff theory of solutions.
description: 7 pages, 6 figures; v2: Minor title change
Cryptoeconomy in Science
Creators: name: Bartling
Publisher: name: Zenodo
Year: 2019

description: The exploration of applications for blockchain technology for science is still in its infancy. This talk provides an introduction from Bitcoin to token economics. It explores New deals on data provide new ways of data handing, privacy and data value, while making data available that is currently unused. Data handling is distributed away from one single entity to many, smart contracts can be used to proveably constrain the access to the data (e.g. respecting privacy). Token economies may create novel incentive structures that improve the sharing of data and quality assurance.
Solitary wave solution to the generalized nonlinear Schrodinger equation for dispersive permittivity and permeability
Creators: name: Sarma, Amarendra K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Classical Physics (physics.class-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a solitary wave solution of the generalized nonlinear Schrodinger equation for dispersive permittivity and permeability using a scaling transformation and coupled amplitude-phase formulation. We have considered the third-order dispersion effect (TOD) into our model and show that soliton shift may be suppressed in a negative index material by a judicious choice of the TOD and self-steepening parameter.
description: 6 pages
Discrete integrable systems and deformations of associative algebras
Creators: name: Konopelchenko, B. G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Rings and Algebras (math.RA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Interrelations between discrete deformations of the structure constants for associative algebras and discrete integrable systems are reviewed. A theory of deformations for associative algebras is presented. Closed left ideal generated by the elements representing the multiplication table plays a central role in this theory. Deformations of the structure constants are generated by the Deformation Driving Algebra and governed by the central system of equations. It is demonstrated that many discrete equations like discrete Boussinesq equation, discrete WDVV equation, discrete Schwarzian KP and BKP equations, discrete Hirota-Miwa equations for KP and BKP hierarchies are particular realizations of the central system. An interaction between the theories of discrete integrable systems and discrete deformations of associative algebras is reciprocal and fruitful.An interpretation of the Menelaus relation (discrete Schwarzian KP equation), discrete Hirota-Miwa equation for KP hierarchy, consistency around the cube as the associativity conditions and the concept of gauge equivalence, for instance, between the Menelaus and KP configurations are particular examples.
description: contribution to the special SIDE issue of J.Phys.A: Math.Theor. Corrected typos
Carbon nanotubes as ultra-high quality factor mechanical resonators
Creators: name: Huettel, A. K.
name: Steele, G. A.
name: Witkamp, B.
name: Poot, M.
name: Kouwenhoven, L. P.
name: van der Zant, H. S. J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have observed the transversal vibration mode of suspended carbon nanotubes at millikelvin temperatures by measuring the single-electron tunneling current. The suspended nanotubes are actuated contact-free by the radio frequency electric field of a nearby antenna; the mechanical resonance is detected in the time-averaged current through the nanotube. Sharp, gate-tuneable resonances due to the bending mode of the nanotube are observed, combining resonance frequencies of up to ν_0 = 350 MHz with quality factors above Q = 10^5, much higher than previously reported results on suspended carbon nanotube resonators. The measured magnitude and temperature dependence of the Q-factor shows a remarkable agreement with the intrinsic damping predicted for a suspended carbon nanotube. By adjusting the RF power on the antenna, we find that the nanotube resonator can easily be driven into the non-linear regime.
description: 18 pages including supplementary information, fixed minor LaTeX figure reference labelling problem