cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design, synthesis and biological activity of novel Xuetongsu derivatives as potential anticancer agents by inducing apoptosis
Creators: name: Jiang, Qi
name: Zhong, Hui
name: Wu, Cong
name: Li, Jia
name: Chen, Jingmin
name: Zhou, Xudong
name: Li, Bin
name: Yu, Huanghe
name: Wang, Wei
name: Sheng, Wenbing
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Xuetongsu (XTS, Schisanlactone E) is one of the main active compounds and considered as the star molecule isolated from Kadsura heteroclita (Roxb.) Craib. In order to improve XTS anti-tumour bioactivities, a series of novel XTS derivatives were designed and synthesised by introducing an amide bond at the parent. Anti-proliferative assays on four different human tumour cell lines (BGC-823, HepG-2, HCT-116, and MCF-7) showed that the anti-tumour activities of most derivatives increased greatly compared to the parent XTS, and especially, compounds A-7, A-14, and A-18 exhibited multiple anti-tumour effects. Among them, compound A-7 has the best biological activities on the four tumour cell lines with the IC50 values ranging from 13.86 to 20.71 μM, which could significantly increase the fraction of apoptotic cells according to flow cytometry experience. Further study demonstrated that A-7 could induce apoptosis on HepG-2 cells through influencing the key apoptotic related proteins, such as Bcl-2, Bax, and cleaved Caspase-3.
title: LPP-Befragungsdaten verknüpft mit administrativen Daten des IAB (LPP-ADIAB) 1975-2021
Creators: name: Mackeben, Jan
name: Ruf, Kevin
name: Wolter, Stefanie
name: Grunau, Philipp
Publisher: name: Forschungsdatenzentrum der Bundesagentur für Arbeit (BA) im Institut für Arbeitsmarkt- und Berufsforschung (IAB)
Year: 2023
Subjects: subject: German administrative micro data
subject: labour market data
subject: linked employer-employee data
subject: data manual

description: Dieser Datenreport beschreibt die verknüpften Daten der Befragung "Linked Personnel Panel" (LPP) mit administrativen Daten des Instituts für Arbeitsmarkt- und Berufsforschung (IAB) von 1975 bis 2021.
description: FDZ-Datenreport
materials – Supplemental material for Intergroup contact fosters more inclusive social identities
Creators: name: Reimer, Nils Karl
name: Shanmukh Vasant Kamble
name: Schmid, Katharina
name: Hewstone, Miles
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, materials for Intergroup contact fosters more inclusive social identities by Nils Karl Reimer, Shanmukh Vasant Kamble, Katharina Schmid and Miles Hewstone in Group Processes & Intergroup Relations
Additional file 2 of “You’re actually part of the team”: a qualitative study of a novel transitional role from medical student to doctor
Creators: name: Natalie, Edmiston
name: Wendy, Hu
name: Stephen, Tobin
name: Jannine, Bailey
name: Caroline, Joyce
name: Krista, Reed
name: Lise, Mogensen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 2.
Cathelicidin-3 Associated With Serum Extracellular Vesicles Enables Early Diagnosis of a Transmissible Cancer
Creators: name: Espejo, Camila
name: Wilson, Richard
name: Pye, Ruth J
name: Ratcliffe, Julian
name: Ruiz-Aravena, Manuel
name: Willms, Eduard
name: Wolfe, Barrett W
name: Hamede, Rodrigo
name: Hill, Andrew
name: Jones, Menna E
name: Woods, Gregory M
name: Lyons, A Bruce
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3105
subject: Genetics
subject: FOS: Biological sciences
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 3211
subject: Oncology and carcinogenesis

description: The identification of practical early diagnostic biomarkers is a cornerstone of improved prevention and treatment of cancers. Such a case is devil facial tumor disease (DFTD), a highly lethal transmissible cancer afflicting virtually an entire species, the Tasmanian devil (Sarcophilus harrisii). Despite a latent period that can exceed one year, to date DFTD diagnosis requires visual identification of tumor lesions. To enable earlier diagnosis, which is essential for the implementation of effective conservation strategies, we analyzed the extracellular vesicle (EV) proteome of 87 Tasmanian devil serum samples using data-independent acquisition mass spectrometry approaches. The antimicrobial peptide cathelicidin-3 (CATH3), released by innate immune cells, was enriched in serum EV samples of both devils with clinical DFTD (87.9% sensitivity and 94.1% specificity) and devils with latent infection (i.e., collected while overtly healthy, but 3-6 months before subsequent DFTD diagnosis; 93.8% sensitivity and 94.1% specificity). Although high expression of antimicrobial peptides has been mostly related to inflammatory diseases, our results suggest that they can be also used as accurate cancer biomarkers, suggesting a mechanistic role in tumorous processes. This EV-based approach to biomarker discovery is directly applicable to improving understanding and diagnosis of a broad range of diseases in other species, and these findings directly enhance the capacity of conservation strategies to ensure the viability of the imperiled Tasmanian devil population.
Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation
Creators: name: Lin, Ching
name: Hsu, Jui-Ling
name: Hsu, Yu-Tung
name: Fan, Kuo-Chen
name: Wu, Sian-Siou
name: Lin, Miao-Hsia
name: Guh, Jih-Hwa
name: Yu, Chao-Wu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: The enigmatic histone deacetylase 6 (HDAC6) is one of a kind among its family. Recent reports revealed that HDAC6 CD1 exhibits E3 ligase activity. Inspired by these researches, we attempted to develop drugs targeting HDAC6 via novel mechanism. Herein, we report a palladium catalysed transformation and purification method for hydroxamic acid dimers, and series of HDAC6 inhibitor-based dimer showing outstanding biological activities and capability of inducing auto-degradation. Our proof-of-concept was highlighted with 2-amino benzamide-based HDAC6 inhibitor dimers that exhibit great HDAC6 inhibition activity (3.9–15.4 nM), good HDAC1/6 selectivity (95–577), and excellent cytotoxicity against human hormone-resistant prostate cancer (HRPC) PC-3 and non-small cell lung cancer (NSCLC) A549 cell lines (5.9–11.3 and 6.6–17.9 μM, respectively) while simultaneously inducing HDAC6 degradation. These dimers not only induce apoptosis and autophagy but also interfere with kinetochore attachment by the detection of BUBR1 phosphorylation at S670.
Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling
Creators: name: Foo, SL
name: Sachaphibulkij, K
name: Lee, CLY
name: Yap, GLR
name: Cui, J
name: Arumugam, Thiruma
name: Lim, LHK
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Background: Despite advancements in therapies, brain metastasis in patients with triple negative subtype of breast cancer remains a therapeutic challenge. Activated microglia are often observed in close proximity to, or within, malignant tumor masses, suggesting a critical role that microglia play in brain tumor progression. Annexin-A1 (ANXA1), a glucocorticoid-regulated protein with immune-regulatory properties, has been implicated in the growth and metastasis of many cancers. Its role in breast cancer-microglia signaling crosstalk is not known. Methods: The importance of microglia proliferation and activation in breast cancer to brain metastasis was evaluated in MMTV-Wnt1 spontaneous mammary tumor mice and BALBc mice injected with 4T1 murine breast cancer cells into the carotid artery using flow cytometry. 4T1 induced-proliferation and migration of primary microglia and BV2 microglia cells were evaluated using 2D and coculture transwell assays. The requirement of ANXA1 in these functions was examined using a Crispr/Cas9 deletion mutant of ANXA1 in 4T1 breast cancer cells as well as BV2 microglia. Small molecule inhibition of the ANXA1 receptor FPR1 and FPR2 were also examined. The signaling pathways involved in these interactions were assessed using western blotting. The association between lymph node positive recurrence-free patient survival and distant metastasis-free patient survival and ANXA1 and FPR1 and FPR2 expression was examined using TCGA datasets. Results: Microglia activation is observed prior to brain metastasis in MMTV-Wnt1 mice with primary and secondary metastasis in the periphery. Metastatic 4T1 mammary cancer cells secrete ANXA1 to promote microglial migration, which in turn, enhances tumor cell migration. Silencing of ANXA1 in 4T1 cells by Crispr/Cas9 deletion, or using inhibitors of FPR1 or FPR2 inhibits microglia migration and leads to reduced activation of STAT3. Finally, elevated ANXA1, FPR1 and FPR2 is significantly associated with poor outcome in lymph node positive patients, particularly, for distant metastasis free patient survival. Conclusions: The present study uncovered a network encompassing autocrine/paracrine ANXA1 signaling between metastatic mammary cancer cells and microglia that drives microglial recruitment and activation. Inhibition of ANXA1 and/or its receptor may be therapeutically rewarding in the treatment of breast cancer and secondary metastasis to the brain.
Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells
Creators: name: El-Wakil, Marwa H.
name: Ghazala, Rasha A.
name: El-Dershaby, Hadeel A.
name: Drozdowska, Danuta
name: Wróbel-Tałałaj, Agnieszka
name: Parzych, Cezary
name: Ratkiewicz, Artur
name: Kolesińska, Beata
name: El-Razik, Heba A. Abd
name: Soliman, Farid S. G.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: In light of searching for new breast cancer therapies, DNA-targeted small molecules were rationally designed to simultaneously bind DNA and inhibit human dihydrofolate reductase (hDHFR). Fourteen new arylidene-hydrazinyl-1,3-thiazoles (5–18) were synthesised and their dual DNA groove binding potential and in vitro hDHFR inhibition were performed. Two compounds, 5 and 11, proved their dual efficacy. Molecular docking and molecular dynamics simulations were performed for those active derivatives to explore their mode of binding and stability of interactions inside DHFR active site. Anti-breast cancer activity was assessed for 5 and 11 on MCF-7 cells using MTX as reference. IC50 measurements revealed that both compounds were more potent and selective than MTX. Cytotoxicity was examined against normal skin fibroblasts to examine safety and selectivity Moreover, mechanistic studies including apoptosis induction and wound healing were performed. Further in silico ADMET assessment was conducted to determine their eligibility as drug leads suitable for future optimisation and development.
Effect of vaginal antiseptic prior to caesarean section on the rate of post-caesarean complications: a blinded randomised controlled trial
Creators: name: Trivedi, M
name: Robinson, Ainsley
name: Islam, MD Rafiqul
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3215
subject: Reproductive medicine
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4202
subject: Epidemiology
classificationCode: 4203
subject: Health services and systems
classificationCode: 4204
subject: Midwifery

description: Background: Rates of caesarean section (CS) delivery are increasing worldwide. CS delivery is often complicated by post-surgical infection, estimated to have ten times higher risk of infections than that of vaginal delivery. While widespread use of prophylactic antibiotics with CS has reduced post-CS infection, incidence may be reduced further by cleansing the vagina with betadine antiseptic wash prior to CS. However, reports are not consistent, and different antiseptics have been practised variably. Therefore, in order to ensure that the risks to the mother are as minimal as possible, it is important to determine whether vaginal irrigation with antiseptic wash reduces post-CS infection rate, and if so, which antiseptic is paramount. Methods: Women giving birth by elective or emergency CS will be assigned into either the intervention (1% povidone iodine (n = 125) or chlorhexidine (n = 125)) or the control (no-irrigation (n = 125)) group by using a block randomisation technique. Participants will receive vaginal cleansing with an intervention or no vaginal cleansing prior to CS. Follow-up will occur at day 14 and day 28 post-CS. A predeveloped questionnaire will be completed with patients’ socio-demographic characteristics and required clinical and pregnancy-related information. All the fever, infection and readmission-related information will be completed from either the patient’s or their record or at follow-up visits. Occurrence of post-CS infection, as measured by primary and secondary outcomes, will be compared between the groups. Discussion: The results of this study may provide important data to define the future uniform use of vaginal antiseptic wash immediately prior to CS and to determine the best antiseptic wash details in reducing post-operative infections or complications. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000971932p. Registered on 28 September 2020
Additional file 1 of Attitudes toward depression among Ecuadorian physicians using the Spanish-validated version of the Revised Depression Attitude Questionnaire (R-DAQ)
Creators: name: Valdevilla Figueira, José Alejandro
name: Mautong, Hans
name: Camacho L, Genesis
name: Cherrez, Michelle
name: Orellana Román, Carlos
name: Alvarado-Villa, Geovanny Efraín
name: Sarfraz, Zouina
name: Sarfraz, Azza
name: Agolli, Arjola
name: Farfán Bajaña, María José
name: Vanegas, Emanuel
name: Felix, Miguel
name: Michel, Jack
name: Espinoza-Fuentes, Fernando
name: Maquilón, Jaime Rosero
name: Cherrez Ojeda, Ivan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Additional file 1: Table S1. Frequency of responses to R-DAQ items reflecting a positive attitude towards depression by factor.
Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation
Creators: name: Mu, Jie
name: Chen, Si-Si
name: Li, Shi-Qing
name: Jin, Qiang
name: Geng, Jin
name: Zou, Li-Wei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Virology

description: ER carboxylesterase 1A (CES1A) is an important metabolic enzyme involved in lipid metabolism. Targeting the CES1A is a promising approach for diseases associated with disorders of lipid metabolism therapy. In this study, screening of 26 natural lignans, three of them were found displaying potent inhibition on CES1A and high specificity over other serine hydrolases. Inhibition kinetic analyses demonstrated that Schisandrin C and Anwuligan were mixed-type inhibitors, while Magnolol acts as a competitive inhibitor. Further investigation showed that they were cell permeable and exhibited minimal cytotoxicity and mitochondrial toxicity, as well as capable of inhibiting intracellular CES1A in living cells. Further investigation found that three Schisandras decreased the number of lipid droplets (LDs) in free fatty acid (FFA)-treated HepG2 cells. Collectively, our findings suggest that Schisandrin C is a potent and highly selective inhibitor of CES1A, which can be served as a promising lead compound.
Supplementary_File__Table_2_sup – Supplemental material for Ageism, Personal and Others’ Perceptions of Age Awareness, and Their Interactive Effect on Subjective Accelerated Aging
Creators: name: Bergman, Yoav S.
name: Palgi, Yuval
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Supplementary_File__Table_2_sup for Ageism, Personal and Others’ Perceptions of Age Awareness, and Their Interactive Effect on Subjective Accelerated Aging by Yoav S. Bergman and Yuval Palgi in Journal of Applied Gerontology
title: NEPS-SC4 survey data linked to administrative data of the IAB (NEPS-SC4-ADIAB)
Creators: name: Bachbauer, Nadine
name: Wolf, Clara
Publisher: name: Forschungsdatenzentrum der Bundesagentur für Arbeit (BA) im Institut für Arbeitsmarkt- und Berufsforschung (IAB)
Year: 2023
Subjects: subject: German administrative micro data
subject: labour market data
subject: data manual
subject: National Educational Panel Study
subject: survey data

description: Dieser Datenreport beschreibt die verknüpften Erhebungsdaten des Nationalen Bildungspanels der Startkohorte 4 „Schule und Ausbildung Bildung von Schülerinnen und Schülern ab Klassenstufe 9“ (NEPS-SC4) mit administrativen Daten des Instituts für Arbeitsmarkt- und Berufsforschung (IAB).
description: FDZ-Datenreport
Effect of vaginal antiseptic prior to caesarean section on the rate of post-caesarean complications: a blinded randomised controlled trial
Creators: name: Trivedi, M
name: Robinson, AM
name: Islam, MD Rafiqul
Publisher: name: La Trobe
Year: 2022

description: Background: Rates of caesarean section (CS) delivery are increasing worldwide. CS delivery is often complicated by post-surgical infection, estimated to have ten times higher risk of infections than that of vaginal delivery. While widespread use of prophylactic antibiotics with CS has reduced post-CS infection, incidence may be reduced further by cleansing the vagina with betadine antiseptic wash prior to CS. However, reports are not consistent, and different antiseptics have been practised variably. Therefore, in order to ensure that the risks to the mother are as minimal as possible, it is important to determine whether vaginal irrigation with antiseptic wash reduces post-CS infection rate, and if so, which antiseptic is paramount. Methods: Women giving birth by elective or emergency CS will be assigned into either the intervention (1% povidone iodine (n = 125) or chlorhexidine (n = 125)) or the control (no-irrigation (n = 125)) group by using a block randomisation technique. Participants will receive vaginal cleansing with an intervention or no vaginal cleansing prior to CS. Follow-up will occur at day 14 and day 28 post-CS. A predeveloped questionnaire will be completed with patients’ socio-demographic characteristics and required clinical and pregnancy-related information. All the fever, infection and readmission-related information will be completed from either the patient’s or their record or at follow-up visits. Occurrence of post-CS infection, as measured by primary and secondary outcomes, will be compared between the groups. Discussion: The results of this study may provide important data to define the future uniform use of vaginal antiseptic wash immediately prior to CS and to determine the best antiseptic wash details in reducing post-operative infections or complications. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000971932p. Registered on 28 September 2020
Additional file 8 of Genomic landscapes of ovarian clear cell carcinoma from latin countries reveal aberrations linked to survival and progression
Creators: name: Batista, Mariana de Paiva
name: Roffé, Martín
name: Romero, Ignacio
name: López-Guerrero, José Antonio
name: Illueca, Carmen
name: Lopez, Raquel
name: Balieiro Anastácio da Costa, Alexandre André
name: De Brot, Louise
name: Molina, Juan Pablo
name: Barboza, Laura
name: Peria, Fernanda Maris
name: Chaud, Fernando
name: Gouvêa Yamada, Ana Silvia
name: Poveda, Andres
name: Rego, Eduardo Magalhães
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Fig and Supplementary Tables
Working from home in Australia during the COVID-19 pandemic: cross-sectional results from the Employees Working From Home (EWFH) study
Creators: name: Oakman, Jodi
name: Kinsman, Natasha
name: Lambert, Katrina
name: Stuckey, Margaret
name: Graham, Melissa
name: Weale, Victoria
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Objectives To investigate the impacts, on mental and physical health, of a mandatory shift to working from home during the COVID-19 pandemic. Design Cross sectional, online survey. Setting Online survey was conducted from September 2020 to November 2020 in the general population. Participants Australian residents working from home for at least 2 days a week at some time in 2020 during the COVID-19 pandemic. Main outcome measures Demographics, caring responsibilities, working from home arrangements, work-related technology, work-family interface, psychosocial and physical working conditions, and reported stress and musculoskeletal pain. Results 924 Australians responded to the online questionnaire. Respondents were mostly women (75.5%) based in Victoria (83.7%) and employed in the education and training and healthcare sectors. Approximately 70% of respondents worked five or more days from home, with only 60% having a dedicated workstation in an uninterrupted space. Over 70% of all respondents reported experiencing musculoskeletal pain or discomfort. Gendered differences were observed; men reported higher levels of family to work conflict (3.16±1.52 to 2.94±1.59, p=0.031), and lower levels of recognition for their work (3.75±1.03 to 3.96±1.06, p=0.004), compared with women. For women, stress (2.94±0.92 to 2.66±0.88, p<0.001) and neck/shoulder pain (4.50±2.90 to 3.51±2.84, p<0.001) were higher than men and they also reported more concerns about their job security than men (3.01±1.33 to 2.78±1.40, p=0.043). Conclusions Preliminary evidence from the current study suggests that working from home may impact employees' physical and mental health, and that this impact is likely to be gendered. Although further analysis is required, these data provide insights into further research opportunities needed to assist employers in optimising working from home conditions and reduce the potential negative physical and mental health impacts on their employees.
Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency
Creators: name: Joushomme, Alexandre
name: Désilets, Antoine
name: Champagne, William
name: Hassanzadeh, Malihe
name: Lemieux, Gabriel
name: Gravel-Trudeau, Alice
name: Lepage, Matthieu
name: Lafrenière, Sabrina
name: Froehlich, Ulrike
name: List, Karin
name: Boudreault, Pierre-Luc
name: Leduc, Richard
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: TMPRSS13, a member of the Type II Transmembrane Serine Proteases (TTSP) family, is involved in cancer progression and in respiratory virus cell entry. To date, no inhibitors have been specifically developed for this protease. In this study, a chemical library of 65 ketobenzothiazole-based peptidomimetic molecules was screened against a proteolytically active form of recombinant TMPRSS13 to identify novel inhibitors. Following an initial round of screening, subsequent synthesis of additional derivatives supported by molecular modelling revealed important molecular determinants involved in TMPRSS13 inhibition. One inhibitor, N-0430, achieved low nanomolar affinity towards TMPRSS13 activity in a cellular context. Using a SARS-CoV-2 pseudovirus cell entry model, we further demonstrated the ability of N-0430 to block TMPRSS13-dependent entry of the pseudovirus. The identified peptidomimetic inhibitors and the molecular insights into their potency gained from this study will aid in the development of specific TMPRSS13 inhibitors.
Discovery of a novel PLK1 inhibitor with high inhibitory potency using a combined virtual screening strategy
Creators: name: Xu, Zhen
name: Guan, Lixia
name: Wang, Yuting
name: Niu, Miao-Miao
name: Ruan, Yashi
name: Xu, Cen
name: Yang, Li
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: PLK1 is essential for cell cycle regulation and proliferation, and its elevated expression in prostate cancer is associated with high tumour grade. Therefore, PLK1 inhibition is considered a promising strategy for the treatment of prostate cancer. Here, we identified five compounds (Hits 1-5) targeting the kinase domain (KD) of PLK1 using a combined virtual screening approach. Hits 1-5 all had picomolar (pM) inhibitory potency against PLK1. Notably, Hit-4 showed the strongest inhibitory activity against PLK1 (IC50 = 22.61 ± 1.12 pM) and displayed high selectivity for PLK1. Meanwhile, molecular dynamics (MD) simulations revealed that the complex formed by Hit-4 and PLK1 remained stable. Importantly, Hit-4 exhibited potent inhibitory effects on the proliferation of DU-145 prostate cancer cells (IC50 = 0.09 ± 0.01 nM). In conclusion, Hit-4 is a potent and highly selective antitumor candidate with therapeutic potential for prostate cancer.
Working from home in Australia during the COVID-19 pandemic: cross-sectional results from the Employees Working From Home (EWFH) study
Creators: name: Oakman, Jodi
name: Kinsman, Natasha
name: Lambert, K
name: Stuckey, Margaret
name: Graham, Melissa
name: Weale, Victoria
Publisher: name: La Trobe
Year: 2022

description: Objectives To investigate the impacts, on mental and physical health, of a mandatory shift to working from home during the COVID-19 pandemic. Design Cross sectional, online survey. Setting Online survey was conducted from September 2020 to November 2020 in the general population. Participants Australian residents working from home for at least 2 days a week at some time in 2020 during the COVID-19 pandemic. Main outcome measures Demographics, caring responsibilities, working from home arrangements, work-related technology, work-family interface, psychosocial and physical working conditions, and reported stress and musculoskeletal pain. Results 924 Australians responded to the online questionnaire. Respondents were mostly women (75.5%) based in Victoria (83.7%) and employed in the education and training and healthcare sectors. Approximately 70% of respondents worked five or more days from home, with only 60% having a dedicated workstation in an uninterrupted space. Over 70% of all respondents reported experiencing musculoskeletal pain or discomfort. Gendered differences were observed; men reported higher levels of family to work conflict (3.16±1.52 to 2.94±1.59, p=0.031), and lower levels of recognition for their work (3.75±1.03 to 3.96±1.06, p=0.004), compared with women. For women, stress (2.94±0.92 to 2.66±0.88, p<0.001) and neck/shoulder pain (4.50±2.90 to 3.51±2.84, p<0.001) were higher than men and they also reported more concerns about their job security than men (3.01±1.33 to 2.78±1.40, p=0.043). Conclusions Preliminary evidence from the current study suggests that working from home may impact employees' physical and mental health, and that this impact is likely to be gendered. Although further analysis is required, these data provide insights into further research opportunities needed to assist employers in optimising working from home conditions and reduce the potential negative physical and mental health impacts on their employees.
Geolinguistica, sociolinguistica e cronologia: le dimensioni del mutamento
Creators: name: Lazzeroni, Romano
Publisher: name: Atti del sodalizio glottologico milanese
Year: 2017

description: This paper discusses the stages of linguistic historiography leading from the genealogical tree, where the linguistic change is conceived as a one-dimensional event (i.e., change through time), to the geolinguistic approach, providing a two-dimensional image (i.e, change thorugh time and space), and eventually to sociolinguistics, which represents the linguistic change according to a three-layer scheme (time, space and diastratic level of speakers). It is shown that the geolinguistic two-dimensional approach is not able to provide chronological clues. Moreover, some tendencies are
taken into account, resulting from the matching of the outputs of linguistic change with the system where it takes place. Finally, the paper attemps to distinguish those changes due to irradiation from those ensuing from polygenesis.
description: Atti del sodalizio glottologico milanese, V. 2014, N. 9 (2016)
Protocol for the Let's Grow randomised controlled trial: examining efficacy, cost-effectiveness and scalability of a m-Health intervention for movement behaviours in toddlers
Creators: name: Hesketh, KD
name: Downing, KL
name: Galland, BC
name: Nicholson, Jan
name: Taylor, R
name: Orellana, L
name: Abdelrazek, M
name: Koorts, H
name: Brown, V
name: Haines, J
name: Campbell, KJ
name: Barnett, LM
name: Löf, M
name: Moodie, M
name: Carson, V
name: Salmon, J
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: INTRODUCTION: Despite being an important period for the development of movement behaviours (physical activity, sedentary behaviour and sleep), few interventions commencing prior to preschool have been trialled. The primary aim of this trial is to assess the 12-month efficacy of the Let's Grow mHealth intervention, designed to improve the composition of movement behaviours in children from 2 years of age. Let's Grow is novel in considering composition of movement behaviours as the primary outcome, using non-linear dynamical approaches for intervention delivery, and incorporating planning for real-world implementation and scale-up from its inception. METHODS AND ANALYSIS: A randomised controlled trial will test the effects of the 12-month parental support mHealth intervention, Let's Grow, compared with a control group that will receive usual care plus electronic newsletters on unrelated topics for cohort retention. Let's Grow will be delivered via a purpose-designed mobile web application with linked SMS notifications. Intervention content includes general and movement-behaviour specific parenting advice and incorporates established behaviour change techniques. Intervention adherence will be monitored by app usage data. Data will be collected from participants using 24-hour monitoring of movement behaviours and parent report at baseline (T0), mid-intervention (T1; 6 months post baseline), at intervention conclusion (T2; 12 months post baseline) and 1-year post intervention (T3; 2 years post baseline). The trial aims to recruit 1100 families from across Australia during 2021. In addition to assessment of efficacy, an economic evaluation and prospective scalability evaluation will be conducted. ETHICS AND DISSEMINATION: The study was approved by the Deakin University Human Ethics Committee (2020-077). Study findings will be disseminated through publication in peer-reviewed journals, presentation at scientific and professional conferences, and via social and traditional media. TRIAL REGISTRATION NUMBER: ACTRN12620001280998; U1111-1252-0599.
Per un nuovo campo disciplinare: l’interlinguistica
Creators: name: Orioles, Vincenzo
Publisher: name: Atti del sodalizio glottologico milanese
Year: 2017

description: Interlinguistics is a field of study which investigates various phenomena relating to the encounters between two or more languages or varieties and their speakers both in the past and the present. The aim of this work is to focus the attention to the various terms at disposal, in the course of time, to describe this phenomenon: Sprachmischung (i.e. linguistic mixture) borrowing, language contact; interference and finally interlinguistics are considered. Regarding the latter label, the different
definitions adopted in literature are also presented and discussed, with a preference for the Roberto Gusmani’s interpretation.
description: Atti del sodalizio glottologico milanese, V. 2014, N. 9 (2016)
Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D
Creators: name: Lee, Hyeonmin
name: Park, Hyunjae
name: Kwak, Kiwoong
name: Lee, Chae-eun
name: Yun, Jiwon
name: Lee, Donghyun
name: Lee, Jung Hun
name: Lee, Sang Hee
name: Kang, Lin-Woo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: β-lactams have been the most successful antibiotics, but the rise of multi-drug resistant (MDR) bacteria threatens their effectiveness. Serine β-lactamases (SBLs), among the most common causes of resistance, are classified as A, C, and D, with numerous variants complicating structural and substrate spectrum comparisons. This study compares representative SBLs of these classes, focusing on the substrate-binding pocket (SBP). SBP is kidney bean-shaped on the indented surface, formed mainly by loops L1, L2, and L3, and an additional loop Lc in class C. β-lactams bind in a conserved orientation, with the β-lactam ring towards L2 and additional rings towards the space between L1 and L3. Structural comparison shows each class has distinct SBP structures, but subclasses share a conserved scaffold. The SBP structure, accommodating complimentary β-lactams, determines the substrate spectrum of SBLs. The systematic comparison of SBLs, including structural compatibility between β-lactams and SBPs, will help understand their substrate spectrum.
title: LPP survey data linked with administrative data of the IAB (LPP-ADIAB) 1975-2021
Creators: name: Mackeben, Jan
name: Ruf, Kevin
name: Wolter, Stefanie
name: Grunau, Philipp
Publisher: name: Forschungsdatenzentrum der Bundesagentur für Arbeit (BA) im Institut für Arbeitsmarkt- und Berufsforschung (IAB)
Year: 2023
Subjects: subject: German administrative micro data
subject: labour market data
subject: linked employer-employee data
subject: data manual

description: Dieser Datenreport beschreibt die verknüpften Daten der Befragung "Linked Personnel Panel" (LPP) mit administrativen Daten des Instituts für Arbeitsmarkt- und Berufsforschung (IAB) von 1975 bis 2021.
description: FDZ-Datenreport
Improving Data Quality through Data Stewardship: An emerging Community of Data Stewards in Germany
Creators: name: Dierkes, Jens
name: Hausen, Daniela Adele
Publisher: name: Zenodo
Year: 2025
Subjects: subject: data stewardship
subject: Community of Practice

description: These are the slides of the lightning talk "Improving Data Quality through Data Stewardship: An emerging Community of Data Stewards in Germany" presented at E-Science-Tage 2025 in Heildelberg.
Additional file 1 of Impact of the first COVID-19 epidemic wave in a large French network of nursing homes: a cross-sectional study
Creators: name: Mbalayen, Fabrice
name: Mir, Sarah
name: de l’Estoile, Valentine
name: Letty, Aude
name: Le Bruchec, Solenn
name: Pondjikli, Manon
name: Seringe, Elise
name: Berrut, Gilles
name: Kabirian, Fariba
name: Fourrier, Marie-Anne
name: Armaingaud, Didier
name: Josseran, Loïc
name: Delarocque-Astagneau, Elisabeth
name: Gautier, Sylvain
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1: Survey questionnaire translated from French
title: Pierre Reverdy : lyrisme de la réalité. Poétique du visuel
Creators: name: Brogly, Marie-Noëlle
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2013

description: This thesis aims to provide the first complete study of the poetics of Pierre Reverdy, who, although famous and influential during his lifetime, has not been widely published or researched. This thesis hopes to change this, as his complete works are just now being republished. The first chapter lays the basis for his conception of reality as something in which man is trapped, and which calls for a distance that, in Reverdy’s eyes, only poetry can offer. His association of the image and lyricism, is presented and analysed. The second chapter aims to provide a linguistic understanding of the poetic image called for and devises the new concept of “illumination”, to give an account of the phenomenon at work in his verse. The third chapter focuses on lyricism, as Reverdy tries to reinvent it for the twentieth century: independent of the self, dealing only with expressing the affective tonalities of the poet and acting as a catalyst for the image. The last chapter defines the visual qualities of Reverdy’s poetry by first re-examining the title of cubist poet that had been attached to him, before focussing on the many forms that the image takes in his work (imagery, but also typography, mental imagery), and finally providing the first analysis of the relationship between paintings and poems in the famous Livres d’artistes that the poet created, in collaboration with Picasso, Matisse, Juan Gris and others. It establishes that while the poems can indeed be read without the illustrations with which they were conceived, these editions deprive the reader of the opportunity to remind himself that poetry is an experience rather than a quest for meaning and also of an introduction to the unique visual qualities of Reverdy’s poetry.
Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus
Creators: name: Suraweera, Chathura
name: Hinds, MG
name: Kvansakul, Marc
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Numerous large DNA viruses have evolved sophisticated countermeasures to hijack the premature programmed cell death of host cells post-infection, including the expression of proteins homologous in sequence, structure, or function to cellular Bcl-2 proteins. Kaposi sarcoma herpes virus (KSHV), a member of the gammaherpesvirinae, has been shown to encode for KsBcl-2, a potent inhibitor of Bcl-2 mediated apoptosis. KsBcl-2 acts by directly engaging host pro-apoptotic Bcl-2 proteins including Bak, Bax and Bok, the BH3-only proteins; Bim, Bid, Bik, Hrk, Noxa and Puma. Here we determined the crystal structures of KsBcl-2 bound to the BH3 motif of pro-apoptotic proteins Bid and Puma. The structures reveal that KsBcl-2 engages pro-apoptotic BH3 motif peptides using the canonical ligand binding groove. Thus, the presence of the readily identifiable conserved BH1 motif sequence “NWGR” of KsBcl-2, as well as highly conserved Arg residue (R86) forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that mimics the canonical ionic interaction seen in host Bcl-2:BH3 motif complexes. These findings provide a structural basis for KSHV mediated inhibition of host cell apoptosis and reveal the flexibility of virus encoded Bcl-2 proteins to mimic key interactions from endogenous host signalling pathways.
Bioactivity profiling of Sanghuangporus lonicerinus: antioxidant, hypoglycaemic, and anticancer potential via in-vitro and in-silico approaches
Creators: name: Gafforov, Yusufjon
name: Bekić, Sofija
name: Yarasheva, Manzura
name: Mišković, Jovana
name: Živanović, Nemanja
name: Chen, Jia Jia
name: Petri, Edward
name: Abdullaev, Bekhzod
name: Rapior, Sylvie
name: Lim, Young Won
name: Abdullaev, Ikram
name: Abbasi, Arshad Mehmood
name: Ghosh, Soumya
name: Al Qadr Imad Wan-Mohtar, Wan Abd
name: Rašeta, Milena
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: This study investigates the mycochemical profile and biological activities of hydroethanolic (EtOH), chloroform (CHCl3), and hot water (H2O) extracts of Sanghuangporus lonicerinus from Uzbekistan. Antioxidant capacity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), NO, and FRAP assays, and in vitro hypoglycaemic effects were evaluated through α-amylase and α-glucosidase inhibition. Antiproliferative potential was explored by analysing the binding affinities of EtOH and H2O extracts to estrogen receptor α (ERα), ERβ, androgen receptor (AR), and glucocorticoid receptor (GR), with molecular docking providing structural insights. LC-MS/MS analysis revealed solvent-dependent phenolic profiles, with the EtOH extract containing the highest total phenolic content (143.15 ± 6.70 mg GAE/g d.w.) and the best antioxidant capacity. The EtOH extract showed significant hypoglycaemic effects, with 85.29 ± 5.58% inhibition of α-glucosidase and 41.21 ± 0.79% inhibition of α-amylase. Moderate ERβ binding suggests potential for estrogen-mediated cancer therapy, while strong AKR1C3 inhibition by the EtOH extract supports its therapeutic potential.
What effect did the American revolution have on slavery ?
Creators: name: Somefun, Oluwasegun
Publisher: name: unknown
Year: 2022

description: To find my primary sources for my question, I first typed my question into google. Here I found a few web pages that gave some primary sources from American and British perspectives on the war and the impact of slavery. Furthermore, I used google Scholar to give my thesis a more balanced view. I was then led to some books via google. However, instead of reading the whole book, I typed in keywords relevant to m questions, Such as slavery and revolution, to make my research more focused.
Here's a list of all the sources: https://www.digitalhistory.uh.edu/active_learning/explorations/revolution/revolution_slavery.cfm, https://www.americanrevolutioninstitute.org/slavery-rights-and-the-meaning-of-the-american-revolution/ https://books.google.com/books?hl=en&lr=&id=4Ck7AAAAIAAJ&oi=fnd&pg=PP8&dq=what+effect+did+american+revolution+have+on+slavery&ots=LNRGVQe6Rj&sig=qEes-NMweTv99NhkesXjmm1NlRM#v=onepage&q&f=false
https://www.jdnews.com/story/opinion/letters/2016/03/19/american-revolution-in-part-motivated-by-slavery/32373080007/

https://books.google.com/books?hl=en&lr=&id=Wa9eun5ElEgC&oi=fnd&pg=PP1&dq=what+effect+did+american+revolution+have+on+slavery&ots=z877KP27YO&sig=CmtDKcFF6k-Ls_b9qO-WHmQsYNc#v=onepage&q=what%20effect%20did%20american%20revolution%20have%20on%20slavery&f=false
Panesneu, martyr and deacon from Pagerge in the district of Oxyrhynchos (Middle Egypt), tried under the hegemon Culcianus, most likely in Alexandira
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Panesneu, martyr and deacon from Pagerge in the district of Oxyrhynchos (Middle Egypt), tried under the hegemon Culcianus, most likely in Alexandira.
مجلة القانون والأعمال الدولية الاصدار رقم 56 فبراير / مارس 2025
Creators: name: Mustapha, Alfurke
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 480102
subject: Commercial law

description: مجلة القانون والأعمال الدولية الاصدار رقم 56 فبراير / مارس 2025
Tetra-anionic porphyrin mimics protein-protein interactions between regulatory particles and the catalytic core, allosterically activating human 20S proteasome
Creators: name: Santoro, A. M.
name: Persico, M.
name: D’Urso, A.
name: Cunsolo, A.
name: Tkachuk, O.
name: Milardi, D.
name: Purrello, R.
name: Tundo, G. R.
name: Sbardella, D.
name: Osmulski, P. A.
name: Gaczynska, M.
name: Coletta, M.
name: Fattorusso, C.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Computational Biology

description: Decreased proteasome activity is a hallmark of brain and retinal neurodegenerative diseases (Alzheimer’s, Parkinson’s diseases, glaucoma) boosting the search for molecules acting as proteasome activators. Based on the hypothesis of an electrostatic key code driving catalytic core particle (20S) activation by regulatory particles (RPs), we identified the tetra-anionic meso-Tetrakis(4-sulphonatophenyl)-porphyrin (H2TPPS) as a new activator of human proteasome. By means of an integrated approach, including bioinformatics, enzymatic kinetic analysis, atomic force microscopy, and dynamic docking simulations, we show how binding of H2TPPS affects the closed/open conformational equilibrium of human 20S to ultimately promote substrate gate opening and proteolytic activity. These outcomes support our hypothesis and pave the way to the rational discovery of new proteasome allosteric modulators able to reproduce the key structural elements of regulatory particles responsible for catalytic activation.
Arianos, martyr and hegemon at Antinoopolis, suffers martyrdom in Antiochia at the hands of Diocletain
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Arianos, martyr and hegemon at Antinoopolis, suffers martyrdom in Antiochia at the hands of Diocletain.