cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Twistors and supertwistors for exceptional field theory
Creators: name: Cederwall, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: As a means of examining the section condition and its possible solutions and relaxations, we perform twistor transforms related to versions of exceptional field theory with Minkowski signature. The spinor parametrisation of the momenta naturally solves simultaneously both the mass-shell condition and the (weak) section condition. It is shown that the incidence relations for multi-particle twistors force them to share a common section, but not to be orthogonal. The supersymmetric extension contains additional scalar fermionic variables shown to be kappa-symmetry invariants. We speculate on some implications, among them a possible relation to higher spin theory.
description: 14 pp. v2: minor changes
Conformational occlusion of blockade antibody epitopes, a novel mechanism of GII.4 human norovirus immune evasion
Creators: name: Corti, Davide
name: Donaldson, Kari
name: Brewer-Jensen, Paul D.
name: Swann, Excel W.
name: Debbink, Kari
name: Graham, Rachel L.
name: Lindesmith, Lisa C.
name: Lanzavecchia, Antonio
name: Baric, Ralph S.
name: Mallory, Michael M.
name: Sheahan, Timothy P.
name: Beltramello, Martina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross-protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, although rare, antibodies to conserved GII.4 blockade epitopes are generated. The mechanisms by which these epitopes evade immune surveillance are uncertain. Here, we developed a new approach for identifying conserved GII.4 norovirus epitopes. Utilizing a unique set of virus-like particles (VLPs) representing the in vivo-evolved sequence diversity within an immunocompromised person, we identify key residues within epitope F, a conserved GII.4 blockade antibody epitope. The residues critical for antibody binding are proximal to evolving blockade epitope E. Like epitope F, antibody blockade of epitope E was temperature sensitive, indicating that particle conformation regulates antibody access not only to the conserved GII.4 blockade epitope F but also to the evolving epitope E. These data highlight novel GII.4 mechanisms to protect blockade antibody epitopes, map essential residues of a GII.4 conserved epitope, and expand our understanding of how viral particle dynamics may drive antigenicity and antibody-mediated protection by effectively shielding blockade epitopes. Our data support the notion that GII.4 particle breathing may well represent a major mechanism of humoral immune evasion supporting cyclic pandemic virus persistence and spread in human populations.

IMPORTANCE In this study, we use norovirus virus-like particles to identify key residues of a conserved GII.4 blockade antibody epitope. Further, we identify an additional GII.4 blockade antibody epitope to be occluded, with antibody access governed by temperature and particle dynamics. These findings provide additional support for particle conformation-based presentation of binding residues mediated by a particle “breathing core.” Together, these data suggest that limiting antibody access to blockade antibody epitopes may be a frequent mechanism of immune evasion for GII.4 human noroviruses. Mapping blockade antibody epitopes, the interaction between adjacent epitopes on the particle, and the breathing core that mediates antibody access to epitopes provides greater mechanistic understanding of epitope camouflage strategies utilized by human viral pathogens to evade immunity.
Compare the efficacy and safety of 308 nm excimer laser combined with PRP in the treatment of vitiligo: a protocol for meta-analysis
Creators: name: Zhang, Ke
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Diseases
subject: Medicine and Health Sciences
subject: Skin and Connective Tissue Diseases

description: Vitiligo is an acquired pigmentary disorder characterized by local white macules of the skin. At present, the therapeutic measures of vitiligo include phototherapies, topical therapies, oral treatments, surgical treatments, etc [1]. The 308nm excimer laser has the advantages of good efficacy and few adverse events. In clinical practice, it is often combined with other therapeutic measures (eg., topical tacrolimus) to treat vitiligo, and combined treatments often show better repigmentation effect [2]. Platelet-rich plasma (PRP) is a preparation containing a variety of growth factors obtained by centrifugal autologous blood, which has attracted more in dermatology [3]. In recent years, researchers have used 308nm excimer laser combined with PRP in the treatment of vitiligo, but its efficacy remains controversial [4-5]. We hope to explore the efficacy and safety of 308 excimer laser combined with PRP in the treatment of vitiligo through meta-analysis. As far as we know, there is no relevant meta-analysis.
Magneto-optical coupling in whispering gallery mode resonators
Creators: name: Haigh, J. A.
name: Langenfeld, S.
name: Lambert, N. J.
name: Baumberg, J. J.
name: Ramsay, A. J.
name: Nunnenkamp, A.
name: Ferguson, A. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate that yttrium iron garnet microspheres support optical whispering gallery modes similar to those in non-magnetic dielectric materials. The direction of the ferromagnetic moment tunes both the resonant frequency via the Voigt effect as well as the degree of polarization rotation via the Faraday effect. An understanding of the magneto-optical coupling in whispering gallery modes, where the propagation direction rotates with respect to the magnetization, is fundamental to the emerging field of cavity optomagnonics.
description: 5 pages, 4 figures
Enhancing insecticide activity of anacardic acid by intercalating it into MgAl layered double hydroxides nanoparticles
Creators: name: Nguyen, T. Nhu Quynh
name: Le, Van Anh
name: Hua, Quyet Chien
name: Nguyen, Tien Thang
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: MgAl layered double hydroxides nanoparticles (LDHs) are known as the useful materials in agrochemsitry. LDHs can be used as a bio-insecticide carrier to enhance insecticide’s activity efficiency. In our study, to improve the insecticide activity of anacardic acid, an extract from cashew nut shell liquid, we intercalated it MgAl layered double hydroxides nanoparticles. Different hybridization between anacardic acid and LDHs (37, 74, 148, and 296µg/mL) (L-As) were made and tested on the survivals of cutworms (Spodoptera litura). L-As or free anacardic acid was sprayed directly on the leaves mustard to feed cutworms or directly on the skin of cutworms. Our results showed that in all L-As treatments, the worm killing efficiency was higher than the free anacardic acid treatment. Hạt nano lớp đôi hydroxides MgAl (LDHs) được biết đến như là những vật liệu hữu ích trong nông ngành hóa học nông nghiệp. LDHs có thể được dùng như là một loại chất mang cho thuốc trừ sâu sinh học để tăng cường hiệu lực diệt sâu. Trong nghiên cứu này, để tăng cường hiệu lực diệt sâu của anacardic acid, một loại hoạt chất được chiết từ dầu vỏ hạt điều, chúng tôi đã gắn chèn nó lên hạt nano lớp đôi hydroxides MgAl. Các nồng độ khác nhau của dạng lai của anacardic và LDHs (37, 74, 148 và 296µg/mL) (L-As) đã được kiểm tra tỷ lệ sống của ấu trùng sâu khoang (Spodoptera litura). Các nghiệm thức L-As và dạng anacardic acid tự do đã được phun lên lá rau cải ngọt cho ấu trùng sâu ăn hoặc phun trực tiếp lên da ấu trùng sâu. Kết quả cho thấy, tất cả các công thức có xử lý bằng L-As, hiệu lực diệt ấu trùng sâu đều cao hơn so với dạng anacardic acid ở trạng thái tự do.
description: Journal of Vietnamese Environment, Vol 6 No 3 (2014)
Frozen-in Fractals All Around: Inferring the Large Scale Effects of Small-Scale Magnetic Structure
Creators: name: McAteer, R. T. James
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The large-scale structure of the magnetic field in the solar corona provides the energy to power large-scale solar eruptive events. Our physical understanding of this structure, and hence our ability to predict these events, is limited by the type of data currently available. It is shown that the multifractal spectrum is a powerful tool to study this structure, by providing a physical connection between the details of photospheric magnetic gradients and current density at all size scales. This uses concepts associated with geometric measure theory and the theory of weakly differentiable functions to compare Ampère's law to the wavelet-transform modulus maximum method. The Hölder exponent provides a direct measure of the rate of change of current density across spatial size scales. As this measure is independent of many features of the data (pixel resolution, data size, data type, presence of quiet-Sun data), it provides a unique approach to studying magnetic-field complexity and hence a potentially powerful tool for a statistical prediction of solar-flare activity. Three specific predictions are provided to test this theory: the multifractal spectra will not be dependent on the data type or quality; quiet-Sun gradients will not persist with time; structures with large current densities at large size scale will be the source of energy storage for solar eruptive events.
Production of renewable biofuels and chemicals by processing bio-feedstock in conventional petroleum refineries
Creators: name: Vu, Xuan Hoan
name: Nguyen, Sura
name: Dang, Thanh Tung
name: Armbruster, Udo
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: The influence of catalyst characteristics, i.e., acidity and porosity on the product distribution in the cracking of triglyceride-rich biomass under fluid catalytic cracking (FCC) conditions is reported. It has found that the degradation degree of triglyceride molecules is strongly dependent on the catalysts’ acidity. The higher density of acid sites enhances the conversion of triglycerides to lighter products such as gaseous products and gasoline-range hydrocarbons. The formation of gasoline-range aromatics and light olefins (propene and ethene) is favored in the medium pore channel of H-ZSM-5. On the other hand, heavier olefins such as gasoline-range and C4 olefins are formed preferentially in the large pore structure of zeolite Y based FCC catalyst (Midas-BSR). With both catalysts, triglyceride molecules are mainly converted to a mixture of hydrocarbons, which can be used as liquid fuels and platform chemicals. Hence, the utilization of the existing FCC units in conventional petroleum refineries for processing of triglyceride based feedstock, in particular waste cooking oil may open the way for production of renewable liquid fuels and chemicals in the near future. Bài báo trình bày kết quả nghiên cứu khả năng tích hợp sản xuất nhiên liệu sinh học và hóa phẩm từ nguồn nguyên liệu tái tạo sinh khối giầu triglyceride bằng công nghệ cracking xúc tác tấng sôi (FCC) trong nhà máy lọc dầu. Kết quả nghiên cứu cho thấy xúc tác có ảnh hưởng mạnh đến hiệu quả chuyển hóa triglyceride thành hydrocarbon. Tính acid của xúc tác càng mạnh thì độ chuyển hóa càng cao và thu được nhiều sản phẩm nhẹ hơn như xăng và các olefin nhẹ. Xúc tác vi mao quản trung bình như H-ZSM-5 có độ chọn lọc cao với hợp chất vòng thơm thuộc phân đoạn xăng và olefin nhẹ như propylen và ethylen. Với kích thước vi mao quản lớn, xúc tác công nghiệp FCC dựa trên zeolite Y ưu tiên hình thành C4 olefins và các olefin trong phân đoạn xăng. Ở điều kiện phản ứng của quá trình FCC, triglyceride chuyển hóa hiệu quả thành hydrocarbon mà có thể sử dụng làm xăng sinh học cho động cơ và olefin nhẹ làm nguyên liệu cho tổng hợp hóa dầu.
description: Journal of Vietnamese Environment, Vol 6 No 3 (2014)
Electrocaloric effect in Ba(0.2)Ca(0.8)Ti(0.95)Ge(0.05)O(3) determined by a new pyroelectric method
Creators: name: Asbani, B.
name: Dellis, J. -L.
name: Gagou, Y.
name: Kaddoussi, H.
name: Lahmar, A.
name: Amjoud, M.
name: Mezzane, D.
name: Kutnjak, Z.
name: Marssi, M. El
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The present letter explores the electrocaloric effect (ECE) in the lead free oxide Ba0.8Ca0.2Ti0.95Ge0.05O3 ceramics (BCTG). The electrocaloric responsivity (dT/dE) was determined by two different methods using the Maxwell relationship (dT/dE)~(dP/dT)_E. In a first well-known indirect method, P-E hysteresis loops were measured in a wide temperature range from which the pyroelectric coefficient p_E=(dP/dT)_E and thus (dT/dE) were determined by derivation of P(T,E) data. In the second novel method the pyroelectric coefficient p_E and consequently the electrocaloric responsivity was determined by direct measurements of the pyroelectric currents under different applied electric fields. Within the experimental error good agreement was obtained between two methods with an electrocaloric responsivity equal to 0.18 +/- 0.05 10-6 K.m.V-1 was obtained at about 410 K
description: 5 pages, 4 figures
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
Creators: name: Hevner, Robert F
name: Thiel, Jeff
name: Li, Junwei
name: Dewey, Elyse C
name: Kapur, Raj P
name: Nelson, Branden R.
name: Stencel-Baerenwald, Jennifer E
name: Grant, Richard F.
name: Widman, Douglas G
name: Jensen, Kara
name: Medwid, Joseph T.
name: Tisoncik-Go, Jennifer
name: Swanstrom, Jesica A.
name: Gao, Xiaohu
name: Roby, Justin A
name: Dobyns, William B
name: Gough, G Michael
name: Walker, Christie L
name: Gale Jr., Michael
name: Kuller, LaRene
name: Shaw, Dennis WW
name: Lee, Wonsok
name: Hodge, Rebecca D
name: Adams Waldorf, Kristina M
name: Baldessari, Audrey
name: Rajagopal, Lakshmi
name: Coleman, Michelle
name: Vornhagen, Jay
name: Studholme, Colin
name: English, Chris
name: Boldenow, Erica
name: Santana-Ufret, Veronica
name: Dighe, Manjiri K
name: Gatenby, Chris
name: Fairgrieve, Marian R.
name: Ogle, Jason
name: Hanley, Kathryn A.
name: Davis, Michael A
name: Durning, W. McIntyre
name: Merillat, Sean
name: Baric, Ralph S.
name: Armistead, Blair
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of ZIKV infection, we demonstrate that ZIKV-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. A common and subtle injury pattern was identified, including (i) periventricular T2-hyperintense foci and loss of fetal noncortical brain volume, (ii) injury to the ependymal epithelium with underlying gliosis and (iii) loss of late fetal neuronal progenitor cells in the subventricular zone (temporal cortex) and subgranular zone (dentate gyrus, hippocampus) with dysmorphic granule neuron patterning. Attenuation of fetal neurogenic output demonstrates potentially considerable teratogenic effects of congenital ZIKV infection even without microcephaly. Our findings suggest that all children exposed to ZIKV in utero should receive long-term monitoring for neurocognitive deficits, regardless of head size at birth.
Biomass and carbon stocks of the natural forests at Me Linh biodiversity station, Vinh Phuc province, Vietnam
Creators: name: Dang, Thi Thu Huong
name: Do, Huu Thu
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: Biomass and carbon stock of the natural forests in Vietnam are still not clear due to limitation of knowledge and financial. In this paper, the results of estimating biomass and carbon stocks of the natural forests at Me Linh Biodiversity Station are shown. There are two forest types in this study: the forest vegetation restored after shifting cultivation (vegetation type I) and the forest vegetation restored after clear cutting exploitation (vegetation type II). As the results, the estimated biomass of the forest vegetation restored after shifting cultivation is 86.80 ton.ha-1 and the estimated biomass of the forest vegetation restored after clear cutting exploitation is higher, about 131.59 ton.ha-1. The carbon stock in plants was about 43.40 ton.ha-1 of vegetation type I and 65.79 ton.ha-1 of vegetation type II. The carbon storage in soil of vegetation type I is 79.01 ton.ha-1 and vegetation type II is 99.65 ton.ha-1. Hence, the total of carbon stock in forest vegetation I and II are accounted by 122.41ton.ha-1 and 165.44 ton.ha-1, respectively. In general, it can be pointed out that the naturally recovering secondary forest at Me Linh Station is the secondary young forest with the low economic value due to shortly restored process (about 10-20 years), the flora is not rich and abundant, and there are only commonly pioneer and light demanding tree species. Sinh khối và trữ lượng các bon của rừng tự nhiên ở Việt Nam vẫn ít được quan tâm của do hạn chế về kiến thức và tài chính. Trong bài báo này, chúng tôi đưa ra kết quả của việc ước lượng sinh khối và tổng hợp các bon của các thảm thực vật rừng thứ sinh phục hồi tự nhiên tại Trạm Đa dạng Sinh học Mê Linh, tỉnh Vĩnh Phúc - Việt Nam, nơi có loại hình thảm thực vật chính, đó là thảm thực vật phục hồi sau nương rẫy (kiểu thảm thục vật I) và thảm thực vật phục hồi sau khai thác kiệt (kiểu thảm thực vật II) nhằm mục đích đánh giá tiềm năng của rừng thứ sinh tại khu vực nghiên cứu. Sinh khối của thảm thực vật phục hồi sau nương rẫy là 86,80 tấn/ha. Sinh khối của thảm thực vật phục hồi sau khai thác cao hơn, đạt 131.59 tấn/ha. Lượng các bon hấp thu trong đất của thảm thực vật I là 79,01 tấn/ha và thảm thực vật II là 99,65 tấn/ha. Như vậy, tổng lượng các bon được hấp thu trong mỗi loại hình thảm thực vật trên là: 122,41 tấn/ha (thảm thực vật I) và 165,14 tấn/ha. Nhìn chung, rừng thứ sinh phục hồi tự nhiên tại Trạm Đa dạng Mê Linh chủ yếu là rừng non thứ sinh, ít có giá trị kinh tế do quá trình phục hồi diễn ra ngắn (khoảng 10-20 năm) nên thành phần thực vật nghèo nàn, không phong phú, thành phần chính chủ yếu là các cây gỗ tiên phong, ưa sáng.
description: Journal of Vietnamese Environment, Vol 6 No 3 (2014)
A feasibility study of an integrated couples-based supportive programme for Chinese couples living with colorectal cancer
Creators: name: Xingjuan Luo-Jieyu Li-Qian Cao-Liya Sun-Ying Chen-Jie Zhao-Qiuping Li
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: feasibility study

description: We tested the feasibility, acceptability, and preliminary efficacy of using an integrated approach combining online and in-person delivery to support colorectal cancer (CRC) patients and their spousal caregivers coping positively with cancer together. We found that this integrated couples-based intervention combining online resources and face-to-face sessions is a unique and important promising new approach. It is feasible and acceptable for couples coping with CRC and shows potential efficacy. The main strengths of the present study were the dyadic data from both CRC patients and their spousal caregivers. Such study might not only provide evidence for the feasibility, acceptability, and preliminary efficacy of using an integrated approach combining online and in-person delivery to support Chinese CRC couples, but could also encourage healthcare professionals to best integrate the advantages of the Internet and traditional delivery to provide all-round support to increase CRC couples’ access to psychosocial oncology care when making adjustments due to cancer.
Parametrizations of the global 21-cm signal and parameter estimation from single-dipole experiments
Creators: name: Harker, Geraint J. A.
name: Mirocha, Jordan
name: Burns, Jack O.
name: Pritchard, Jonathan R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: One approach to extracting the global 21-cm signal from total-power measurements at low radio frequencies is to parametrize the different contributions to the data and then fit for these parameters. We examine parametrizations of the 21-cm signal itself, and propose one based on modelling the Lyman-alpha background, IGM temperature and hydrogen ionized fraction using tanh functions. This captures the shape of the signal from a physical modelling code better than an earlier parametrization based on interpolating between maxima and minima of the signal, and imposes a greater level of physical plausibility. This allows less biased constraints on the turning points of the signal, even though these are not explicitly fit for. Biases can also be alleviated by discarding information which is less robustly described by the parametrization, for example by ignoring detailed shape information coming from the covariances between turning points or from the high-frequency parts of the signal, or by marginalizing over the high-frequency parts of the signal by fitting a more complex foreground model. The fits are sufficiently accurate to be usable for experiments gathering 1000 h of data, though in this case it may be important to choose observing windows which do not include the brightest areas of the foregrounds. Our assumption of pointed, single-antenna observations and very broad-band fitting makes these results particularly applicable to experiments such as the Dark Ages Radio Explorer, which would study the global 21-cm signal from the clean environment of a low lunar orbit, taking data from the far side.
description: 13 pages, 8 figures
CC002/Unc females are mouse models of exercise-induced paradoxical fat response
Creators: name: Smith-Ryan, Abbie E.
name: Baric, Ralph S.
name: Ferris, Martin T.
name: Hua, Kunjie
name: Pomp, Daniel
name: McMullan, Rachel C.
name: Menachery, Vineet D.
name: de Villena, Fernando Pardo-Manuel
name: Bell, Timothy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Exercise results in beneficial health outcomes and protects against a variety of chronic diseases. However, U.S. exercise guidelines recommend identical exercise programs for everyone, despite individual variation in responses to these programs, including paradoxical fat gain. Experimental models of exercise-induced paradoxical outcomes may enable the dissection of underlying physiological mechanisms as well as the evaluation of potential interventions. Whereas several studies have identified individual mice exhibiting paradoxical fat gain following exercise, no systematic effort has been conducted to identify and characterize models of paradoxical response. Strains from the Collaborative Cross (CC) genetic reference population were used due to its high levels of genetic variation, its reproducible nature, and the observation that the CC is a rich source of novel disease models, to assess the impact genetic background has on exercise responses. We identified the strain CC002/Unc as an exercise-induced paradoxical fat response model in a controlled voluntary exercise study across multiple ages in female mice. We also found sex and genetic differences were consistent with this pattern in a study of forced exercise programs. These results provide a novel model for studies to determine the mechanisms behind paradoxical metabolic responses to exercise, and enable development of more rational personalized exercise recommendations based on factors such as age, sex, and genetic background.
Protocol for a scoping review of policies regarding use of medications for opioid use disorder in professional recovery programs
Creators: name: White, Kelley
name: Hill, Lucas
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Other Rehabilitation and Therapy
subject: Substance Abuse and Addiction
subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: Mental and Social Health
subject: nurses
subject: opioid agonists
subject: opioid use disorder
subject: pharmacists
subject: physicians
subject: professional recovery programs
subject: scoping review

description: A scoping review aimed at summarizing current literature which describes policies related to treatment of opioid use disorder with medications within professional recovery programs for physicians, pharmacists, and nurses.
Combining Visual Analytics and Content Based Data Retrieval Technology for Efficient Data Analysis
Creators: name: Rodrigues, Jose
name: Romani, Luciana
name: Traina, Agma
name: Traina, Caetano
Publisher: name: arXiv
Year: 2015
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: One of the most useful techniques to help visual data analysis systems is interactive filtering (brushing). However, visualization techniques often suffer from overlap of graphical items and multiple attributes complexity, making visual selection inefficient. In these situations, the benefits of data visualization are not fully observable because the graphical items do not pop up as comprehensive patterns. In this work we propose the use of content-based data retrieval technology combined with visual analytics. The idea is to use the similarity query functionalities provided by metric space systems in order to select regions of the data domain according to user-guidance and interests. After that, the data found in such regions feed multiple visualization workspaces so that the user can inspect the correspondent datasets. Our experiments showed that the methodology can break the visual analysis process into smaller problems (views) and that the views hold the expectations of the analyst according to his/her similarity query selection, improving data perception and analytical possibilities. Our contribution introduces a principle that can be used in all sorts of visualization techniques and systems, this principle can be extended with different kinds of integration visualization-metric-space, and with different metrics, expanding the possibilities of visual data analysis in aspects such as semantics and scalability.
description: Published as Jose Rodrigues, Luciana A. S. Romani, Agma Juci Machado Traina, Caetano Traina Jr (2010), Combining Visual Analytics and Content Based Data Retrieval Technology for Efficient Data Analysis, 14th Int Conf on Inf Visualisation, 61-67
100,000 institutions on the Wikimedia projects. A new strategy to activate in a simple way all the institutions around the world
Creators: name: Pensa, Iolanda
Publisher: name: Zenodo
Year: 2023
Subjects: Digital strategy museums
GLAM
WikiGLAM
Wikipedia
Wikimedia projects
Creative Commons licenses

description: A strategy to activate all institutions around the world on the Wikimedia projects: an accompanying path aimed at all institutions to start an open access policy by making 20 images available with open licenses and tools. The proposal is based on the strategy and instruments implemented by the ongoing project "Empowering Italian GLAMs" which focuses on 3'000 Italian museums (promoted Wikimedia Italy, with ICOM Italy, Creative Commons Italy, University of Turin and co-funding Wikimedia Foundation). The current GLAMs model facilitates the collaboration with major institutions that already have extensive digitalizations of their heritage and it involves a Wikipedian in residence. However, this approach is not effective if we want to involve and activate even the smallest institutions that represent most of the world's institutions, which can provide a real diversity of contents and which often intentionally present a divergent perspective with respect to large institutions. Based on the project “Empowering Italian GLAMs" (2022-2024) which is currently targeting 3,000 Italian museums in a particularly complex legislative context, this session presents a strategy baed on a simple communication campaign which invites all institutions to make available 20 images (building and examples of their collections) with open licenses and tools through an online form. The online form does not directly publish images on Wikimedia Commons, but accompanies institutions in a process which allows them to review their data on Wikidata, upload a permission and open access policy, accompany their images with a text and bibliography. This external interface (which subsequently allows to validate and upload contents) allows to manage authorizations and complex legislative situations, it archives documents as a primary source and it provides an institutional mediated contribution to Wikimedia projects. This process is a starting point in creating and implementing an open access policy on a small selection of content, it allows institutions to test “openness” and take advantage of the synergy with the Wikimedia projects (by contributing to Wikimedia Commons, improving data on Wikidata and possibly on one or more Wikipedia articles). By simply focusing on round twenty images, the approach potentially addresses all institutions, even the smallest ones and those who do not currently have digitalizations. Furthermore, rather than focusing on opening the collections, the method is close to communication strategies with which many organizations are already familiar (for example by providing images to journalists or for promotional brochures). The method is a first step in openness which can be followed by further contributions, up to a complete data management plan based on the principle of open by default.
The Role of In-Person Tutorials in Higher Education
Creators: name: Schafmeister, Felix
name: Merkus, Erik
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Education Economics
subject: Education
subject: Labor Economics
subject: Economics
subject: Higher Education
subject: Social and Behavioral Sciences

description: In this project, we estimate the role of online education in small-scale tutorials in which groups of around 25 students, together with a teaching assistant, discuss solutions to problem sets and work through exercises that are closely related to the types of questions students face in the final examination. In order to estimate a causal effect, we use a natural experiment implemented in the academic year 2020/21 at a business school in Sweden that deterministically assigned students to shifting schedules of online vs. in-class tutorials. We combine this feature with disaggregated information about exam scores to estimate the effects of online learning in a within-student design.
The quantum formulation derived from assumptions of epistemic processes
Creators: name: Helland, Inge S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Motivated by Quantum Bayesianism I give background for a general epistemic approach to quantum mechanics, where complementarity and symmetry are the only essential features. A general definition of a symmetric epistemic setting is introduced, and for this setting the basic Hilbert space formalism is arrived at under certain technical assumptions. Other aspects of ordinary quantum mechanics will be developed from the same basis elsewhere.
description: 10 pages
Push button reproduction attempt of a research claim from Turcu, A., & Urbatsch, R., (2015), in Comparative Political Studies
Creators: name: Talbert, Eli
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: We selected the claim that countries are more likely to extend the franchise to their expatriate citizens in the wake of their neighbors’ decisions to do likewise. This reflects the following statement from the paper's abstract: "We use large-N cross-national hazard models to examine whether a similar pattern holds for diaspora enfranchisement and find that neighbors’ recent enactment of overseas voting nearly doubles the chance that a country will enfranchise its own diaspora." The dependent variable equals 1 in years when countries first extended voting rights to citizens abroad and 0 for other country-years, and the authors analyze it with Cox proportional hazards models. Their independent variable of interest, the spatial lag of franchise extensions, is measured in the same way as the dependent variable, but for neighboring countries and for a prior span of time. The baseline models are reported in Table 1. The selected model is column III, and the focal term is 'Recent nearby franchise extension' (see column III in Table 1 for details). In column III of Table 1, having a neighbor who recently instituted voting for non-resident citizens associates with a substantial increase in the likelihood of expanding voting (estimate for 'Recent nearby franchise extension' term = 1.86; t statistic, based on SE clustered by country = 2.92; p < .01 [two-tailed]). The focal test in the original paper is: In column III of Table 1, having a neighbor who recently instituted voting for non-resident citizens associates with a substantial increase in the likelihood of expanding voting (estimate for 'Recent nearby franchise extension' term = 1.86; t statistic, based on SE clustered by country = 2.92; p < .01 [two-tailed]).
Belief Superiority Preregistered Replication
Creators: name: Harris, Elizabeth
name: Van Bavel, Jay
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: There is currently a debate in political psychology about whether dogmatism and belief superiority are symmetric or asymmetric across the ideological spectrum. One study found that dogmatism was higher amongst conservatives than liberals, but both conservatives and liberals with extreme attitudes reported higher perceived belief superiority (Toner, Leary, Asher & Jongman-Sereno, 2013). Our goal was to conduct a pre-registered direct and conceptual replication of this previous research using a larger and more nationally representative sample. Consistent with prior research, we found that conservatives had higher dogmatism scores than liberals while both conservatives and liberals with extreme attitudes were associated with higher belief superiority compared to those with more moderate attitudes. Moreover, whether conservative or liberal attitudes were associated with higher belief superiority was topic dependent. Different from prior research, we found that ideologically extreme individuals had higher dogmatism. We discuss the implications of these results for theoretical debates in political psychology.
Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity
Creators: name: Menachery, Vineet D.
name: Baric, Ralph S.
name: Dinnon III, Kenneth H.
name: Gallichotte, Emily N.
name: Fritch, Ethan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Zika virus (ZIKV) is a mosquito-borne positive sense RNA virus. Recently, ZIKV emerged into the Western hemisphere as a human health threat, with severe disease associated with developmental and neurological complications. The structural envelope protein of ZIKV and other neurotropic flaviviruses contains an extended CD-loop relative to non-neurotropic flaviviruses, and has been shown to augment ZIKV stability and pathogenesis. Here we show that shortening the CD-loop in ZIKV attenuates the virus in mice, by reducing the ability to invade and replicate in the central nervous system. The CD-loop mutation was genetically stable following infection in mice, though secondary site mutations arise adjacent to the CD-loop. Importantly, while shortening of the CD-loop attenuates the virus, the CD-loop mutant maintains antigenicity in immunocompetent mice, eliciting an antibody response that similarly neutralizes both the mutant and wildtype ZIKV. These findings suggest that the extended CD-loop in ZIKV is a determinant of neurotropism and may be a target in live-attenuated vaccine design, for not only ZIKV, but for other neurotropic flaviviruses.
Clinical Motor Coordination Scales in Adult Neurology: A Scoping Review Protocol
Creators: name: Schwartz, Elka
name: Guidry, Kathryn
name: Lee, Amanda
name: Dinh, Danny
name: Demers, Marika
name: Levin, Mindy
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: coordination
subject: neurology
subject: outcome measure
subject: protocol
subject: rehabilitation
subject: scoping review

description: Background: Sensorimotor coordination is an important construct to assess in clinical neurological practice but is often assessed subjectively by therapists. Current clinical outcome measures have been criticized for not capturing movements in both spatial and temporal domains. Objectives: To identify (1) clinical outcome measures of upper limb, lower limb and trunk motor coordination, (2) whether and to what extent scales have been validated and in which neurological population(s), (3) how each outcome measure assesses coordination. Methods: MEDLINE and EMBASE databases will be searched using a combination of keywords related to movement quality, motor performance, motor coordination, assessment, psychometrics and reproducibility of results. Two reviewers will first screen the titles and abstracts and then, screen the full-text to determine eligibility criteria. Publications that describe the development and/or psychometric testing of a clinical outcome measure of coordination will be included. For each included publication, the name of the outcome measure, the body part assessed, the neurological population in which the measure is used, the psychometric properties, and the spatial and/or temporal coordination metrics will be extracted. Discussion: This scoping review will help clinicians identify and select outcome measures to assess sensorimotor coordination. It can also help to highlight the gaps in the literature with regards to sensorimotor coordination assessment in the clinical setting.
BRST Analysis of the Supersymmetric Higher Spin Field Models
Creators: name: Buchbinder, I. L.
name: Koutrolikos, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We develop the BRST approach for all massless integer and half-integer higher spins in 4D Minkowski space, using the two component spinor nota- tion and develop the Lagrangian formulation for supersymmetric higher spin models. It is shown that the problem of second class constraints disappears and the BRST procedure becomes much more simple than in tensorial nota- tion. Furthermore, we demonstrate that the BRST procedure automatically provides extra auxiliary components that belong in the set of supersymmetry auxiliary components. Finally, we demonstrate how supersymmetry transfo- rmations are realized in such an approach. As a result, we conclude that the BRST approach to higher spin supersymmetric theories allows to derive both the Lagrangian and the supersymmetry transformations. Although most part of the work is devoted to massless component supersymmetric models, we also discuss generalization for massive component supersymmetric models and for superfield models.
Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes
Creators: name: Gallichotte, Emily N.
name: Durbin, Anna
name: Baric, Ralph S.
name: Baric, Thomas J.
name: Whitehead, Steve
name: Yount, Jr., Boyd L.
name: Widman, Douglas G.
name: de Silva, Aravinda M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. It is estimated that a third of the world’s population is at risk for infection, with an estimated 390 million infections annually. Dengue virus serotype 2 (DENV2) causes severe epidemics, and the leading tetravalent dengue vaccine has lower efficacy against DENV2 compared to the other 3 serotypes. In natural DENV2 infections, strongly neutralizing type-specific antibodies provide protection against subsequent DENV2 infection. While the epitopes of some human DENV2 type-specific antibodies have been mapped, it is not known if these are representative of the polyclonal antibody response. Using structure-guided immunogen design and reverse genetics, we generated a panel of recombinant viruses containing amino acid alterations and epitope transplants between different serotypes. Using this panel of recombinant viruses in binding, competition, and neutralization assays, we have finely mapped the epitopes of three human DENV2 type-specific monoclonal antibodies, finding shared and distinct epitope regions. Additionally, we used these recombinant viruses and polyclonal sera to dissect the epitope-specific responses following primary DENV2 natural infection and monovalent vaccination. Our results demonstrate that antibodies raised following DENV2 infection or vaccination circulate as separate populations that neutralize by occupying domain III and domain I quaternary epitopes. The fraction of neutralizing antibodies directed to different epitopes differs between individuals. The identification of these epitopes could potentially be harnessed to evaluate epitope-specific antibody responses as correlates of protective immunity, potentially improving vaccine design.
Off-label drug use in chidren over the past decade：A scoping review of translational barriers
Creators: name: Tang, Yuyi
name: Li, Weiguo
name: liu, enmei
name: Baskota, Muna
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Pharmaceutics and Drug Design
subject: Pharmacy and Pharmaceutical Sciences
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Pediatrics
subject: off-label drug use
subject: pediatric
subject: scoping review

description: The use of off-label medicines has long been an important issue in pediatric practice, owing to lack of specific information in pediatric age group. In recent years, off-label drug use has been considered as a priority for clinical researchers, resulting in a variety of designs and topics in current published studies. However, a comprehensive overview of the current evidence on off-label drug use in children is still absent. We therefore conducted a scoping review on off-label drug use in children, aiming to mapping the nature and extent of evidence in this field and promote the transformation and application of off-label drug use researches.
Preregistration - Replication of Pendry (1998) - Version 2 - Sept 2020
Creators: name: Vrantsidis, Thalia
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This preregistration is for a second attempt to replicate Pendry (1998) using a different sample of participants (undergraduates in version 2, vs. online in version 1). This preregistration is largely the same as for version 1, other than changes to sample size and data collecting stopping rules, as well as minor changes to exclusion criteria.
Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections
Creators: name: Baric, Ralph S.
name: Leist, Sarah R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: The laboratory mouse has proved an invaluable model to identify host factors that regulate the progression and outcome of virus-induced disease. The paradigm is to use single-gene knockouts in inbred mouse strains or genetic mapping studies using biparental mouse populations. However, genetic variation among these mouse strains is limited compared with the diversity seen in human populations. To address this disconnect, a multiparental mouse population has been developed to specifically dissect the multigenetic regulation of complex disease traits. The Collaborative Cross (CC) population of recombinant inbred mouse strains is a well-suited systems-genetics tool to identify susceptibility alleles that control viral and microbial infection outcomes and immune responses and to test the promise of personalized medicine.
IMPACT OF SOCIAL RESTRICTION IMPOSED BY 2019-nCOV PANDEMIC ON THE MOBILITY OF OLDER PEOPLE: A SCOPE REVIEW PROTOCOL
Creators: name: Felipe, Sarah
name: Perracini, Monica
name: Batista, Patrícia
name: da Silva, Cristina
name: Melo, Ruth
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences

description: The 2019‑nCoV pandemic represents a high risk for older people that sustain higher mortality rates compared to young adults. Limited social contact and restriction of mobility in the community (stay-at-home precautions) are recognised as measures to prevent SARS-CoV-2 infection among older people. The impact of these measures on health, physical function and emotional wellbeing are numerous, and might result in long-term adverse outcomes such as disability, falls and limited mobility. Thus, the objective of this scope review is to map the estimated impact of measures of social restrictions on the mobility of older people living in the community and to systematize the existing recommendations, anticipating possible intervention strategies gaps.
title: Gezielte Veränderung der DNA-Methylierung im Säugergenom
Creators: name: Galonska, Christina
name: Charlton, Jocelyn
name: Mattei, Alexandra
name: Meissner, Alexander
Publisher: name: Max-Planck-Gesellschaft zur Förderung der Wissenschaften
Year: 2019

description: Während der Entwicklung eines Organismus bleibt die Sequenz der DNA unverändert. Die unterschiedliche Aktivität der Gene in verschiedenen Zellen hingegen wird epigenetisch durch reversible Modifikationen der DNA, vor allem durch die spezifische Ankopplung von Methylgruppen an Cytosine, gesteuert. Wir entwickeln Methoden zur gezielten Methylierung des Genoms an definierten Positionen. Dadurch wollen wir ein umfassendes Verständnis der Rolle der DNA-Methylierung bei der Regulation der Genaktivität gewinnen und damit zu neuen therapeutischen Ansätzen für die Behandlung von Krankheiten beitragen.
Late time attractors of some varying Chaplygin gas cosmological models
Creators: name: Khurshudyan, M.
name: Myrzakulov, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The goal of this paper is to study new cosmological models where the dark energy is a varying Chaplygin gas. This specific dark energy model with non-linear EoS had been often discussed in modern cosmology. Contrary to previous studies, we consider new forms of non-linear non-gravitational interaction between dark matter and assumed dark energy models. We applied the phase space analysis allowing understanding the late time behavior of the models. It allows demonstrating that considered non-gravitational interactions can solve the cosmological coincidence problem. On the other hand, we applied Bayesian Machine Learning technique to learn the constraints on the free parameters. In this way, we gained a better understanding of the models providing a hint which of them can be ruled out. Moreover, the learning based on the simulated expansion rate data shows that the models cannot solve the $H_{0}$ tension problem.
description: New section has been added. Old results have been updated. 19 pages, 4 figures