cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modulating the lipid profile of blastocyst cell membrane with DPPC multilamellar vesicles
Creators: name: De Rossi, Hugo
name: Costa, Camila Bortoliero
name: Rodrigues-Rossi, Luana Teixeira
name: Nunes, Giovana Barros
name: Chéles, Dóris Spinosa
name: Pereira, Isabella Maran
name: Rocha, Daniele F. O.
name: Feitosa, Eloi
name: Simionato, Ana Valéria Colnaghi
name: Mingoti, Gisele Zoccal
name: Aoki, Pedro Henrique Benites
name: Nogueira, Marcelo Fábio Gouveia
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology

description: The aim of this study was to evaluate the effect of multilamellar vesicles (MLVs) of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in co-culture with in vitro-produced bovine embryos (IVPEs). The stability of five concentrations of MLVs (1.0, 1.25, 1.5, 1.75, and 2.0 mM) produced using ultrapure water or embryonic culture medium with 24 or 48 h of incubation at 38.5 °C with 5% CO2 was assessed. In addition, the toxicity of MLVs and their modulation of the lipid profile of the plasma membrane of IVPEs were evaluated after 48 h of co-culture. Both media allowed the production of MLVs. Incubation (24 and 48 h) did not impair the MLV structure but affected the average diameter. The rate of blastocyst production was not reduced, demonstrating the nontoxicity of the MLVs even at 2.0 mmol/L. The lipid profile of the embryos was different depending on the MLV concentration. In comparison with control embryos, embryos cultured with MLVs at 2.0 mmol/L had a higher relative abundance of six lipid ions (m/z 720.6, 754.9, 759.0, 779.1, 781.2, and 797.3). This study sheds light on a new culture system in which the MLV concentration could change the lipid profile of the embryonic cell membrane in a dose-dependent manner.
Treatment-related adverse events of PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors in clinical trials: a meta-analysis
Creators: name: Mi, Ze
name: Zhang, Yunshu
name: Feng, Zhichao
name: Liu, Jiahao
name: Wu, Jianmin
name: Tan, Hongpei
name: Ma, Xiaoqian
name: Liu, Zhenguo
name: Rong, Pengfei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: PD-1/PD-L1 inhibitors in combination with CTLA-4 inhibitors are being tested in a number of ongoing clinical trials. As a result, it is critical to fully comprehend the toxicity characteristics of adverse events in combination therapy. This study aims to extensively compare the incidences and ORs of treatment-related adverse events between two combination strategies. The eligible articles were searched from PubMed, EMBASE and Cochrane databases for studies published between 1 January 2010 and 1 May 2021, investigating PD-1/PD-L1 inhibitors plus CTLA-4 inhibitor-based combined clinical therapies. The mean incidences and pooled ORs of all-grade and grade 3 or higher adverse events were calculated by random-effects model using Stata 12.1. Heterogeneity between studies was assessed with I2 statistics and Chi square-based Q statistic. The overall risk of bias was assessed by Review Manager 5.3. A total of 26 eligible studies of 3607 patients were selected; 2852 patients developed at least one all-grade adverse event. PD-L1 inhibitors plus CTLA-4 inhibitors regimen (incidence 0.67, 95% CI: 0.57–0.77) had marked advantage over PD-1 inhibitors plus CTLA-4 inhibitors regimen (incidence 0.89, 95% CI: 0.86–0.93). PD-L1 inhibitors plus CTLA-4 inhibitors shows better safety in treatment-related adverse events than PD-1 inhibitors plus CTLA-4 inhibitors.
Association between LEPR polymorphism and susceptibility of osteoporosis in Chinese Mulao people
Creators: name: Ye, Guangbin
name: Huang, Yandong
name: Yin, Lianfei
name: Wang, Jianchu
name: Huang, Xiufeng
name: Bin, Xiaoyun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: To explore the association between the single nucleotide polymorphism (SNP) of leptin receptor (LEPR) gene and the susceptibility to osteoporosis (OP) among Chinese Mulao people. A total of 738 people were involved. Bone mineral density (BMD) was examined by calcaneus ultrasound attenuation measurement. Six SNPs of LEPR were detected. The genotypes, allele frequencies, linkage disequilibrium, and haplotype were analyzed. BMD decreased with age and males had higher BMD than women. The proportion of normal bone mass decreased with age, and morbidity of OP increased. Three out of six SNPs showed a difference between OP and normal group. Individuals with AA genotype of rs1137100 in OP group outnumber the normal group, AA increased the risk of OP. In rs2767485, CT increased the risk of OP, C allele may be susceptible to OP. TT genotype of rs465555 was susceptible genotype of OP, T locus may be associated with OP. Strong linkage disequilibrium was detected among rs1137100, rs1137101, and rs4655555. Four haplotypes were constructed, among which, AACGCT and GGTGTA increased the risk of OP by 3.9 and 4.2 times, respectively, whereas, GGCGTA reduced 74% of OP susceptibility. The rs1137100, rs2767485, and rs465555 of LEPR were associated with OP in Chinese Mulao people.
The link between emotion and motor development: an integrated study of movement preparation and performance
Creators: name: Butson, Michael
Publisher: name: RMIT University
Year: 2024

description: Little research has examined the relationship between emotion and motor skill in children, so three studies explored whether healthy 8-to-12-year-old children, with below average motor skills, acquire negative emotional responses to physical activity that are based on a history of poor success in this area. A standard latent-trait model underpinned Study 1, which used self-report to investigate which traits are relevant. The two models that were tested fit the data well however generalized self-efficacy for physical activity was the only significant predictor, regardless of whether the outcome variable was motor skill or attitudes toward physical activity as a means of developing positive relationships. The results were contrary to the assumptions of the latent-trait model, as much of the variance was common and there were moderation and mediation effects. To reconcile the findings an alternative conceptualization of emotion was needed. Consequently, an affective state space model, with valence and arousal as its fundamental dimensions, informed studies two and three. Study 2 used a pictorial scale to determine whether children with below average motor skills display less adaptive affective responses to having their motor skills assessed than typically developing peers. The children were assigned to one of four groups, based on their level of motor skill. There were substantial within-group and between-group effects that showed that the less developed children’s motor skills were, the less adaptive their affective responses to the assessment were. Self-report can only inform us about what can be brought into conscious awareness, so Study 3 used physiological indices of affect to explore aspects of affective responding that are not available to conscious awareness. The children either performed physical tasks or, as there is evidence that memory involves the simulation of sensory experiences associated with past events, they imagined performing a familiar physical activity. The children were assigned to a low motor skill or a high motor skill group. The results showed that prior to performing physical tasks or before imagining performing a physical activity, the low skill groups displayed less positive affective responses than the high skill groups. They also had less positive responses when performing physical tasks or mentally simulating a physical activity. The mental simulation group with low motor skill also appeared to have less positive responses to being questioned about what they imagined. Overall, the substantial effects in the studies supported the proposition that primary-school-aged children with poor motor skills acquire negative emotional responses to physical activity that are likely to be based on a lack of success in this area. Furthermore, the studies appear to be the first to be informed by an affective state space model, and the findings warrant pursuing this approach further.
Additional file 2 of Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Creators: name: Chen, Hui
name: Yamaguchi, Satoshi
name: Wang, Yilin
name: Kaminogo, Kento
name: Sakai, Kiyoshi
name: Hibi, Hideharu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 2: Fig. S1. Description of data: Quantitative analysis of scanning electron microscope images. (A) Diameter of primary and secondary recovery hair shafts. Data are presented as mean ± SEM. ****P < 0.0001. (B) Proportion of primary and secondary recovery hair shafts with surface cracks. (A, B) The dorsa of 18 mice from the three groups (vehicle, N-CM, and H-CM) were divided equally into six regions, and a hair shaft from each region was selected randomly as a representative sample for a total of 108 hair shafts. The sample size of the primary recovery hair was 24 and that of the secondary recovery hair was 84.
Fiche d'inventaire - Objet n° 7336A_B - Crochet de litière
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Fer

description: Source: FCA/3/2
description: Relation: JFCA, tome 23, p. 195
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 7230 (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: Relation: Double de 7230
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 6624 - Prajñaparamitā ?
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Comparison of MDRD, CKD-EPI, and Cockcroft-Gault equation in relation to measured glomerular filtration rate among a large cohort with diabetes
Creators: name: Schwandt, Anke
name: Denkinger, Michael D.
name: Fasching, Peter
name: Pfeifer, Martin
name: Wagner, Christian
name: Weiland, Jörg
name: Zeyfang, Andrej
name: Holl, Reinhard
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Modification of diet in renal disease (MDRD)
subject: Chronic kidney disease epidemiology collaboration (CKD-EPI)
subject: Cockcroft-gault (CG)
subject: Renal-function
subject: Serum creatinine
subject: Diabetes mellitus, Type 1
subject: Diabetes mellitus, Type 2
subject: Glomerular filtration rate
subject: Renal insufficiency, Chronic
subject: Diabetes mellitus Typ 1
subject: Diabetes mellitus Typ 2
subject: Nierenkrankheit
subject: Nierenfunktion

description: Aims: To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population. Methods: 24,516 adults with type-1-diabetes or type-2-diabetes from the multicenter diabetes prospective follow-up registry DPV were analyzed. We compared eGFR and measured GFR (mGFR) based on 24-h urine collection by calculating mean bias (difference), precision (SD of this difference), accuracy (proportion of eGFR within ±10% of mGFR), Bland-Altman-plots. Results: CG overestimates, whereas MDRD, CKD-EPI, and CG-IBW underestimate. Smallest mean bias and highest accuracy (75.3%) were observed for MDRD compared to the other equations (p<0.0001). MDRD and CKD-EPI estimated most accurately in stages 1 (MDRD:57.7%, CKD-EPI:57.3%) and 2 (MDRD:80.2%, CKD-EPI:80.7%). In stages 3 to 5, highest accuracy was observed for the MDRD (stage3:82.3%, stage4:77.8%, stage5:71.0%). Among younger subjects, accuracy was higher using the CKD-EPI (18-<40 years:63.7%, 40-<60 years:72.8%). Above age 60 years, MDRD estimated most accurately (60-<70 years:77.3%, ≥70 years:78.8%). In males and females, MDRD estimated most accurately (males:75.3%, females:75.3%). Conclusion: In this large diabetic cohort, smallest bias and highest accuracy were observed for the MDRD.
Adventitial cystic disease of the popliteal artery
Creators: name: Elst, Janne
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Vascular
subject: CT-Angiography
subject: MR
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Cysts

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 56 years
description: Clinical History: A 56-year-old male presents with hypoesthesia in the calf and lateral foot, corresponding to the innervation of the tibial nerve and pain in the popliteal fossa since many years. Since 2 months, the patient also suffers from claudication, causing pain in ... Final Diagnosis: Cystic adventitial disease of the popliteal artery.
In vitro antiplasmodial activity, hemocompatibility and temporal stability of Azadirachta indica silver nanoparticles
Creators: name: Hawadak, Joseph
name: Foko, Loick Pradel Kojom
name: Pande, Veena
name: Singh, Vineeta
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Recently green nanotechnology has gained great interest as a promising tool for drug discovery. In the present study, we synthesized and characterized silver nanoparticles (AgNPs) using Azadirachta indica (AI) and evaluated their hemocompatibility and effect against Plasmodium falciparum strains. AI leaves and barks were used for aqueous extracts (AIL and AIB) and AgNPs synthesis. AgNPs were characterized using spectroscopic, diffraction, electron microscopic and electrostatic techniques. Anti-plasmodial and haemolytic activity were assessed following the SYBR Green I fluorescence assay and Miki et al. protocol, respectively. The normalized fluorescence counts were plotted against the log-transformed drug concentration and half-maximal inhibitory concentration (IC50) determined by analyzing the dose–response curves. AgNPs were stored for 120 days at room temperature-RT, +4 °C and −20 °C and subsequently their stability was evaluated by spectroscopy. Both NPs were predominantly spheroidal, crystalline in nature, stable, well dispersed with mean size of 13.01 nm for AIL-NPs and 19.30 nm for AIB-NPs and exhibited good antiplasmodial activity against 3D7 and RKL9 P. falciparum strains with IC50 of 9.27 µg/mL and 11.14 µg/mL for AIL-NPs, 8.10 µg/mL and 7.87 µg/mL for AIB-NPs, respectively. A. indica contain bioactive phyto-compounds indicating great potential for anti-malarial drug development through green nanotechnology. The AgNPs were structurally stable after 120 days but antiplasmodial activity was considerably affected. A significant haemolytic activity (>25%) was observed with AIL- and AIB-AgNPs at concentrations ≥125 µg/mL.
Fiche d'inventaire - Objet n° 7143 - Perle
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Reflection reduction through modal filtering for integrated antenna measurements above 100 GHz
Creators: name: Böhm, Linus
name: Förstner, Alexander
name: Hitzler, Martin
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Antenna measurements
subject: Integrated antennas
subject: Modal filtering
subject: DDC 620 / Engineering & allied operations
subject: Antennas (Electronics)
subject: Probes (Electronic instruments)
subject: Antennenmesstechnik
subject: Antenne

description: Feeding integrated antennas during a measurement requires special feeding structures. Due to the small antenna dimensions, these feeding structures are often much bigger than the antenna under test (AUT) itself and with chip sizes of around 1 mm2, the achievable separation between antenna and feed is limited. Wafer probes have to be used to feed the AUT during passive antenna measurements and present a large reflective surface in close proximity to the AUT. Reflections from the wafer probe cause interference on the measurement surface and distort the results. The same is true for active antenna measurements, where bondwires and the package can have a significant effect on the radiated fields. The fragility and size of the components do not allow to reduce reflections with absorbers, which is why modal filtering was used in this paper to mitigate undesired reflections and improve the measurement result through postprocessing. Two issues that limit the performance of the algorithm are discussed, namely, phase center inaccuracies of the AUT and a limited measurement surface. It is shown that modal filtering is applicable to integrated antenna measurements at frequencies over 100 GHz and that a significant improvement in the measured radiation pattern can be achieved. Furthermore, it is shown that the postprocessed results make it possible to measure the directivity of integrated antennas, despite strong probe reflections.
Fiche d'inventaire - Objet n° 7301 - Oiseau
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze
Cuivre

description: Source: FCA/3/2
description: Relation: JFCA, tome 13, p. 240
description: IIIF manifest
description: created: 1950/1970
Additional file 1 of Synthetic modulation of ROS scavenging during host—Sclerotinia sclerotiorum interaction: a new strategy for the development of highly resistant plants
Creators: name: Ding, Yijuan
name: Yan, Baoqin
name: Zhao, Siqi
name: Chen, Yangui
name: Wan, Huafang
name: Qian, Wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Heat map depicting the expression levels of SsCCS, SsSOD, AtCCS, and AtSOD1 during Sclerotinia sclerotiorum inoculation. Figure S2. Phylogenetic relationship of the CCS and SOD genes in S. sclerotiorum and Arabidopsis thaliana. a Phylogenetic relationship of the S. sclerotiorum CCS (SS1G_00102) and the A. thaliana CCS (AT1G12520). b Phylogenetic relationship of the S. sclerotiorum SOD (SS1G_00699) and the A. thaliana SOD genes (AT2G28190, AT5G18100, AT1G08830). Figure S3. Sequence alignment of S. sclerotiorum SsCCS and SsSOD with A. thaliana AtCCS and AtSOD1. The black horizontal lines in the S. sclerotiorum gene indicate the sequences used to construct host-induced gene silencing (HIGS) vectors. Figure S4. Comparison of growth between transgenic and control A. thaliana lines. Figure S5. Relative expression levels of AtCCS and AtSOD1 in transgenic HIGS plants. The expression levels were quantified by normalizing the quantity of A. thaliana AtActin7 and AtActin2 cDNA in different samples. Data are presented as means ± SEM (n = 3, technical replicates). The same letter indicates no statistically significant difference at p > 0.05 (two-sided Student's t-test). The relative expression of the target gene in CK was set as one, respectively. CK: A. thaliana plants carrying the empty vector.
sj-docx-5-jbm-10.1177_03936155221132292 - Supplemental material for Development and validation of a nomogram involving immunohistochemical markers for prediction of recurrence in early low-risk endometrial cancer
Creators: name: Kong, Wei
name: Tu, Yuan
name: Jiang, Peng
name: Huang, Yuzhen
name: Zhang, Jingni
name: Jiang, Shan
name: Li, Ning
name: Yuan, Rui
Publisher: name: SAGE Journals
Year: 2022
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental material, sj-docx-5-jbm-10.1177_03936155221132292 for Development and validation of a nomogram involving immunohistochemical markers for prediction of recurrence in early low-risk endometrial cancer by Wei Kong, Yuan Tu, Peng Jiang, Yuzhen Huang, Jingni Zhang, Shan Jiang, Ning Li and Rui Yuan in The International Journal of Biological Markers
Scenedesmus sempervirens Chodat
Creators: name: Kim, Yong Jae
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Chlorophyta
Chlorophyceae
Sphaeropleales
Scenedesmaceae
Scenedesmus
Scenedesmus sempervirens

description: Scenedesmus sempervirens Chodat (Fig. 4e, f)
 References: Komárek and Fott 1983: 915, pl. 246, fig. 6; Yamagishi and Akiyama 1995: 15:30, figs. 1-5.
 Synonym: Scenedesmus abundance (Kirchner) Chodat sensu auct. Post. Sine type.
 Scenedesmus caudatus var. minor Kützing.
 Scenedesmus spinosus var. crassispinosus Hortobagyi.
 Occurrence site: Chukdong reservoir (WT 28.3℃, pH 8.3. EC 213 μs/cm).
 Description: Cells arranged in coenobia composed of 2-4(-8) cell arranged with sides contacting in a straight (or only rarely curved) line or slightly alternating row. The cells are long and ovoid or ellipsoidal, with conical or rounded poles. Small spines (1-2) occur at the poles of the inner cells. The marginal cells have a slightly curved or straight spine at the poles. The outer side wall of the marginal cells is straight or slightly convex, with 1-2 spines in the center. Each cell has a chloroplast containing a pyrenoid. The cells are 10-20 μm in length and 5-8 μm in width.
 Distribution: Switzerland (Chodat, 1913), cosmopolitan (Komárek and Fott, 1983).
 Specimen: NIBRCL0000112298; DAEJIN-20150603-6.
 Remark: Komárek and Fott (1983) merged S. abundance, S. caudatus var. minor and S. spinosus var. crassispinosus into this species as a synonym. S. abundance probably described a group of several types, as noted by Chodat (1926). According to Komárek and Fott (1983), Theses taxon is included in S. sempervirens.
description: Published as part of Kim, Yong Jae, 2017, New records of coccoid green algae in Korea, pp. 42-50 in Journal of Species Research 6 (1) on pages 48-49, DOI: 10.12651/JSR.2017.6.1.042, http://zenodo.org/record/13137199
sj-docx-1-eab-10.1177_00139165221131002 – Supplemental material for Relationships Among Environmental Attitudes, Environmental Efficacy, and Pro-Environmental Behaviors Across and Within 11 Countries
Creators: name: Miller, Lindsay B.
name: Rice, Ronald E.
name: Gustafson, Abel
name: Goldberg, Matthew H.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-eab-10.1177_00139165221131002 for Relationships Among Environmental Attitudes, Environmental Efficacy, and Pro-Environmental Behaviors Across and Within 11 Countries by Lindsay B. Miller, Ronald E. Rice, Abel Gustafson and Matthew H. Goldberg in Environment and Behavior
Enhanced anti-cancer effect using MMP-responsive L-asparaginase fused with cell-penetrating 30Kc19 protein
Creators: name: Ryu, Jina
name: Yang, Sung Jae
name: Son, Boram
name: Lee, Haein
name: Lee, Jongmin
name: Joo, Jinmyoung
name: Park, Hee Ho
name: Park, Tai Hyun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: As the acute lymphoblastic leukaemia (ALL) develops, expression of L-asparaginase (ASNase) protein is known to decrease. Therefore, deficiency of the ASNase protein would be regarded as one of the significant indications of the ALL. For the treatment of ALL, recombinant ASNase protein derived from bacterial origin is used which causes cytotoxicity by deprivation of Asn. However, short half-life of the protein is an obstacle for medical use. In order to overcome this limit, recombinant ASNase was fused to 30Kc19 with protein-stabilizing and cell-penetrating properties. As the 30Kc19 protein may induce steric hindrance, we further added a PLGLAG linker sequence (LK) between the ASNase and 30Kc19. The treatment of ASNase-LK-30Kc19 fusion protein demonstrated enhanced stability, cell-penetrating property, and anti-cancer activity. Intracellular delivery of both the non-cleaved and cleaved forms of the protein were observed, suggesting that ASNase acted both internally and externally, performing high anti-cancer activity by effective depletion of intracellular Asn. Additionally, ASNase-LK-30Kc19 showed high selectivity towards cancer cells. In terms of the dosage, releasable ASNase from ASNase-LK-30Kc19 reached the same half-maximal inhibitory concentration at a concentration five times lower than non-releasable ASNase-30Kc19. Altogether, the findings suggest that this fusion approach has potential applications in the treatment of ALL.
Additional file 16 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 16: Figure S1. Chemical structures of the three products formed from funneling reactions utilized by microorganisms in the breakdown of organic compounds. Catechol and protocatechuic acid degradation proceeds via the β-ketoadipate pathway while hydroxyquinol is formed from protocatechuate and degraded in an alternative pathway found in some bacteria and fungi.
Absorptive laser threshold magnetometry: combining visible diamond Raman lasers and nitrogen-vacancy centres
Creators: name: Raman Nair, Sarath
name: Rogers, Lachlan J
name: Spence, David J
name: Mildren, Richard P
name: Jelezko, Fedor
name: Greentree, Andrew D
name: Volz, Thomas
name: Jeske, Jan
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: nitrogen-vacancy centres
subject: laser threshold magnetometry
subject: diamond Raman laser
subject: diamond colour centres
subject: optical micro-cavity
subject: DDC 530 / Physics
subject: Raman lasers
subject: Raman-Laser

description: AbstractWe propose a high-sensitivity magnetometry scheme based on a diamond Raman laser with visible pump absorption by an ensemble of coherently microwave driven negatively charged nitrogen-vacancy centres (NV−) in the same diamond crystal. The NV− centres’ absorption and emission are spin-dependent. We show how the varying absorption of the NV− centres changes the Raman laser output. A shift in the diamond Raman laser threshold and output occurs with the external magnetic field and microwave driving. We develop a theoretical framework with steady-state solutions to describe the effects of coherently driven NV− centres including the charge state switching between NV− and its neutral charge state NV0 in a diamond Raman laser. We discuss that such a laser working at the threshold can be employed for magnetic field sensing. In contrast to previous studies on NV− magnetometry with visible laser absorption, the laser threshold magnetometry method is expected to have low technical noise, due to low background light in the measurement signal. For magnetic-field sensing, we project a shot-noise limited DC sensitivity of a few pT /Hz in a well-calibrated cavity with realistic parameters. This sensor employs the broad visible absorption of NV− centres and unlike previous laser threshold magnetometry proposals it does not rely on active NV− centre lasing or an infrared laser medium at the specific wavelength of the NV− centre’s infrared absorption line.
New Zealand dressmaker: experiences, practices and contribution to fashionability, 1940 to 1980
Creators: name: Hamon, Jan
Publisher: name: RMIT University
Year: 2024

description: The rationale behind the research presented in this thesis grew from a perception that, historically, work that was seen to be "women's work" was undervalued or unrecognised, particularly if the work was closely associated with domesticity or the exclusively feminine. Local and international media have shown interest in New Zealand fashion designers in recent years, generally without reference to the history of New Zealand fashion and dressmaking. This research was interested in what had gone before; in what factors conspired to provide the foundation for what is now a profitable commercial fashion industry.

This thesis examined evidence that supported or disproved the hypothesis that the foundations of the industry lay in the expertise attained in a female "domestic" activity carried out in an unbroken tradition. A study was made of the work of home dressmakers in New Zealand during and following World War Two, with a view to evaluating the contribution that these practitioners made to the development of the contemporary fashion industry. A representative group of practitioners was interviewed and their experiences provided the primary research focus for the study.

The study considers the broader historical context, including any unique factors that allowed dressmaking to flourish in New Zealand. The focus is on the work of women who made women's clothes, generally from their own homes or small business premises, and particularly during the period from the 1940s to the 1980s. The research concentrates on the social and economic environment in which the dressmakers worked; their rationale for establishing their businesses; the skills and knowledge that they acquired and utilised; the extent of their production; and the manufacturing and retail opportunities that existed in competition to them. The study concludes with an evaluation of the significance of the dressmakers' contribution to the New Zealand fashion industry and an assessment of the continuation of the tradition of dressmaking in today's world.
MODELLING STORM-INDUCED COASTAL EROSION:A SANTA CRUZ CASE STUDY
Creators: name: Fairlie, Jessica
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: coast
erosion
morphodynamics
storm

description: Coastal erosion is an important product of physical weathering by the ocean, accelerated by strong
storm events. Different morphological aspects of specific areas of interest play an important role in
how a storm will affect the coastline. Swell size, direction, and surge are three storm characteristics
that may be determining factors in coastline erosion rates. Understanding these characteristics in
specific regions would allow for better erosion forecasts for future storms. This research is primarily
a case study focused on one storm event in one region, specifically the erosion to a section of coastline
in Santa Cruz, California caused by a storm on January 5th, 2023. I obtained wave data from an
NDBC buoy during this storm and created a nested wave model in SWAN and examined wave height,
power, and incident angle along the coastline. I compared these results to those of rotated storm
spectra, average summer and winter seasonal wave events, and varied surge heights. I examined
rates of erosion along this section of coastline in relation to the physical characteristics of the storm
and each scenario to determine correlations. I found swell direction, storm surge, and the angle of
the shoreline are key features in predicting erosion. Findings from this study can be replicated for
other areas of interest to evaluate potential erosion from future storms.
Additional file 1 of Identification and expression analyses of B3 genes reveal lineage-specific evolution and potential roles of REM genes in pepper
Creators: name: Park, Young-Soo
name: Cho, Hye Jeong
name: Kim, Seungill
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1
sj-doc-1-npx-10.1177_1934578X221133196 - Supplemental material for Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins
Creators: name: Thanh, Nguyen Ha
name: Phuong, Hoang Thi
name: Tu Anh, Le Thi
name: Thuy Giang, Le Nhat
name: Quynh Giang, Nguyen Thi
name: Anh, Nguyen Tuan
name: Tuyet Anh, Dang Thi
name: Van Kiem, Phan
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-doc-1-npx-10.1177_1934578X221133196 for Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins by Nguyen Ha Thanh, Hoang Thi Phuong, Le Thi Tu Anh and Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Tuan Anh, Dang Thi Tuyet Anh, Phan Van Kiem in Natural Product Communications
Additional file 17 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 17: Figure S2. Schematic of oxygen consumption assay with Clark-type electrode. (A) The Clark type electrode reaction chamber. The rubber seal replaces the microsyringe after injection of the various components into the system. It serves to seal the chamber from external oxygen. (B) A zoom into the electrode unit. The platinum cathode is surrounded by a well that serves as a reservoir for electrolyte solution (50% potassium chloride). During the reaction, the electrolyte is ionized and initiates a current flow from anode to cathode. The current is equivalent to the oxygen concentration in the media. (C) Typical oxygen consumption curve observed when there is substrate cleavage. (D) The curve observed in the absence of substrate cleavage. In the absence of substrate cleavage, catechol was added at the end of the reaction as a control for activity.
Fiche d'inventaire - Objet n° 6958 - Buddha debout
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Additional file 18 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 18: Figure S3. Spectra of selected substrates and their metabolites as detected in negative mode by UPLC-MS. Black peaks represent the substrate while red peaks depict the metabolites. Structures of both the substrate and the metabolite are as shown with their mass to charge ratios. The DOG used in the assay is indicated in blue. A thunderbolt sign shows the ortho-cleavage position.
sj-docx-6-pie-10.1177_09544089221132724 - Supplemental material for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants
Creators: name: Chinnachamy, Rajaganapathy
name: Durairaj, Vasudevan
name: Saravanamuthu, Murugapoopathi
name: Rajagopal, Varthini
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-6-pie-10.1177_09544089221132724 for Evaluation of the effect of silver nanoparticles on the tribological and thermophysical properties of bio-lubricants by Rajaganapathy Chinnachamy, Vasudevan Durairaj, Murugapoopathi Saravanamuthu and Varthini Rajagopal in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Additional file 19 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 19: Figure S4. PCR amplicons of TuDOG7, TuDOG10 and TuDOG11 and their neighboring intron containing eukaryotic genes.
Editorial: Spatial and temporal perception in sensory deprivation
Creators: name: Senna, Irene
name: Cuturi, Luigi F.
name: Gori, Monica
name: Ernst, Marc O.
name: Cappagli, Giulia
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: cortical plasticity
subject: spatial perception
subject: temporal perception
subject: visual impairment
subject: hearing impairment
subject: motor impairment
subject: DDC 620 / Engineering & allied operations
subject: Sensory deprivation
subject: Space perception
subject: Vision disorders
subject: Hearing disorders
subject: Rehabilitation
subject: Sensorische Deprivation
subject: Raumvorstellung

description: The Research Topic aimed at providing new insights into the impact of sensory deprivation on spatio-temporal abilities and their subtending cortical circuits. The Research Topic attracted a wide range of submissions across the spectrum of this theme, and overall, all the submitted papers fall within one of the following topic contributions: (a) papers identifying impaired/preserved abilities after a sensory loss/deprivation; (b) papers investigating cortical plasticity and reorganization mechanisms following sensory loss/deprivation; (c) papers presenting newly developed tools to assess and/or train spatial impairments resulting from sensory loss/deprivation. With this editorial, we intend to discuss the findings of the submitted contributions within the broader context of the literature on the theme by considering the three above-mentioned main contribution categories.
sj-docx-1-tej-10.1177_20417314221130486 – Supplemental material for Multimodal analysis of the differential effects of cyclic strain on collagen isoform composition, fibril architecture and biomechanics of tissue engineered tendon
Creators: name: Janvier, Adam J
name: Pendleton, Emily G
name: Mortensen, Luke J
name: Green, Daniel C
name: Henstock, James R
name: Canty-Laird, Elizabeth G
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-docx-1-tej-10.1177_20417314221130486 for Multimodal analysis of the differential effects of cyclic strain on collagen isoform composition, fibril architecture and biomechanics of tissue engineered tendon by Adam J Janvier, Emily G Pendleton, Luke J Mortensen, Daniel C Green, James R Henstock and Elizabeth G Canty-Laird in Journal of Tissue Engineering
Fiche d'inventaire - Objet n° 64SS367 - Battant de clochette (double)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: Relation: Double de 64SS367
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 7346 - Anneaux (2)
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° 6716 - Plateau
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Cuivre

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Fiche d'inventaire - Objet n° KTM 27 - Clochette
Creators: name: École Française D'Extrême-Orient
name: Conservation D'Angkor
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Bronze

description: Source: FCA/3/2
description: IIIF manifest
description: created: 1950/1970
Microscopic properties of Na and Li—a first principle study of metal battery anode materials
Creators: name: Gaissmaier, Daniel
name: Van Den Borg, Matthias
name: Fantauzzi, Donato
name: Jacob, Timo
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: dendrite formation
subject: density functional theory
subject: metal electrode
subject: DDC 540 / Chemistry & allied sciences
subject: Dendrites
subject: Density functionals
subject: Surface chemistry
subject: Batterie

description: From the atom up: Needle-like dendrite growth may cause internal short circuits or even induce a thermal runaway in metallic Na and Li batteries. Therefore, we have investigated the fundamental diffusion and surface properties of both metals by means of first-principle calculations. These results provide important insights into the diffusion on an atomic level that determines the overall growth phenomena. Using density functional theory, we studied the bulk and surface properties of Li and Na electrodes on an atomistic level. To get a better understanding of the initial stages of surface growth phenomena (and thus dendrite formation), various self-diffusion mechanisms were studied. For this purpose, dedicated diffusion pathways on the surfaces of Na and Li were investigated within the terrace-step-kink (TSK) model utilizing nudged elastic band calculations. We were able to prove that the mere investigation of terrace self-diffusion on the respective low-index surfaces does not provide a possible descriptor for dendritic growth. Finally, we provide an initial view of the surface growth behavior of both alkali metals as well as provide a basis for experimental investigations and theoretical long-scale kinetic Monte Carlo simulations.
Additional file 20 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 20: Figure S5.in situ localization of T. urticae DOG genes (TuDOG11 and TuDOG3). A DIG-labelled antisense probe was used for hybridization and the signal was developed using anti-DIG-AP and FastRed as substrate. The reaction product is visible as a red signal (the cuticle got red staining in both antisense and sense treatment so we consider that as false signals) while the spider mite body shows green auto fluorescence. Abbreviations: C, cuticle; PME, posterior midgut epithelium; PM, posterior midgut; V, ventriculus; VE, ventricular epithelium; Scale bars: 100 μm.
Additional file 1 of Effect of transcutaneous electrical acupoint stimulation on the quality of postoperative recovery: a meta-analysis
Creators: name: Zhang, Meng
name: Zhang, Huanhuan
name: Li, Pan
name: Li, Jianli
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy

description: Supplementary Material 1
Additional file 2 of Effect of transcutaneous electrical acupoint stimulation on the quality of postoperative recovery: a meta-analysis
Creators: name: Zhang, Meng
name: Zhang, Huanhuan
name: Li, Pan
name: Li, Jianli
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy

description: Supplementary Material 2
Supplemental Material - Indigenous Lands are Better for Amphibian Biodiversity Conservation Than Immigrant-Managed Agricultural Lands: A Case Study From Manu Biosphere Reserve, Peru
Creators: name: Serrano-Rojas, Shirley J.
name: Whitworth, Andrew
name: Paredes-Garcia, Julio A.
name: Pillco-Huarcaya, Ruthmery
name: Whittaker, Lawrence
name: Huaypar-Loayza, Karl H.
name: MacLeod, Ross
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Geography
subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography

description: Supplemental Material for Indigenous Lands are Better for Amphibian Biodiversity Conservation Than Immigrant-Managed Agricultural Lands: A Case Study From Manu Biosphere Reserve, Peru by Shirley J. Serrano-Rojas, Andrew Whitworth, Julio A. Paredes-Garcia, Ruthmery Pillco-Huarcaya, Lawrence Whittaker, Karl H. Huaypar-Loayza, and Ross MacLeod in Tropical Conservation Science
Additional file 21 of Intradiol ring cleavage dioxygenases from herbivorous spider mites as a new detoxification enzyme family in animals
Creators: name: Njiru, Christine
name: Xue, Wenxin
name: De Rouck, Sander
name: Alba, Juan M.
name: Kant, Merijn R.
name: Chruszcz, Maksymilian
name: Vanholme, Bartel
name: Dermauw, Wannes
name: Wybouw, Nicky
name: Van Leeuwen, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 21: Figure S6. Stain-free SDS-PAGE (panel a) and western blot (panel b) of purified recombinant T. urticae DOGs. The 6x His tagged proteins are between 25-37 kDa.