cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular Dissection of Pinch: Insights into Integrin Function in Drosophila
Creators: name: Elias, Maria Christina
Publisher: name: University of Utah
Year: 2014

description: Adhesion and migration are required for proper development and for the maintenance of adult tissues. Cellular adhesion is regulated by signaling, adaptor, and actin associated proteins that assemble at the cell cortex in response to integrin activation. PINCH, ILK, and RSU-1 are three such adaptor proteins that form a physical complex downstream of integrins and have evolutionarily conserved overlapping, yet not identical, roles in integrin-mediated adhesion. The 5 LIM domain scaffolding protein PINCH is the central molecule in this complex, making contacts with ILK via LIM1 and RSU-1 via LIM5. In Drosophila, PINCH and ILK are required for maintaining actin-membrane linkages in the embryonic muscle, and null mutant clones in the wing display a loss of adhesion resulting in blisters. RSU-1 is not required for viability, but like PINCH and ILK, is required for maintaining adhesion of the wing epithelia. To further understand the contributions of these proteins to integrin function in vivo, a molecular analysis of PINCH was conducted using mutations that disrupt the interaction with ILK (PINCHQ38A and PINCHΔLIM1) or RSU-1 (PINCHD303V and PINCHΔLIM5). We find that PINCHQ38A transgenes rescue the stck (PINCH) null mutant, and rescued flies display no defects in integrin function. However, a dramatic reduction in viability is observed in PINCHQ38A rescued flies upon loss of RSU-1. Disruption of the PINCH-ILK interaction does not affect the levels of either protein, in contrast to results observed with complete loss of either PINCH or ILK, suggesting that PINCH and ILK mediate other interactions iv that contribute to their function and stability. PINCHΔLIM1 transgenes rescue the late embryonic/early larval lethality of the stck null mutant, but rescued animals only survive to larval and pupal stages, indicating that LIM1 function is required later in development. PINCHD303V transgenes rescue the stck null mutant, although rescued adult flies are not healthy. PINCHD303V rescued flies exhibit reduced levels of RSU-1, which is mislocalized, indicating that the PINCH-RSU-1 interaction is required to maintain levels of RSU-1 and to localize RSU-1 to adhesion sites. PINCHΔLIM5 transgenic flies were also generated, but the transgenes fail to rescue the stck null mutant due to instability of the transgenic protein. Taken together the data presented in this dissertation demonstrate functional consequences of disrupting the PINCH-ILK-RSU-1 complex, and suggest that multiple contacts made by each complex member contribute to protein localization, stability, and function downstream of integrin.
Regulatory mutations affecting amino acid tansport in Chinese hamster ovary (CHO-K1) cells.
Creators: name: DeBusk, Weldon Earl
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Cells

description: Two mutant clones of Chinese hamster ovary (CHO-K1) cells were obtained by selection schemes designed to favor cells with defective amino acid transport through the cationic amino acid transporter, system y+. One of the mutants, CH-K r, was selected for resistance to chronic exposure to high concentrations of lysine and arginine in the growth medium. The other, C2.2, was selected using a suicide protocol that employed a brief exposure to tritiated lysine. As might be expected, transport activity by system y+ was decreased in both mutants. However, the phenotypes of CH-Kr and C2.2 were more complicated and several transport systems were affected. Transport through systems A, L, and y+ was reduced in both mutants, with the effect extending to system ASC in CH-Kr cells. Transport of aspartate through system X[AG-] was not affected in either cell line. Despite the different selection schemes, these mutants appeared initially to be very similar. Other metabolic parameters were measured and compared in both mutants. These results revealed that the mutants differ in many important respects. For example, CH-Kr maintains a lower intracellular sodium concentration than parental cells, whereas no difference in intracellular sodium was detected in C2.2. This was surprising, considering the generally lower transport rates observed in CH-Kr, and was especially puzzling when intracellular amino acid measurements revealed that CH-Kr also maintained reduced intracellular amino acid pools compared to parental cells or C2.2. Reduced internal sodium represents a steeper sodium gradient that would be expected to accelerate instantaneous amino acid uptake and to maintain higher amino acid pools. Taken together, the physiological data presented here imply the existence of a complex regulatory scheme governing the activity of these transporters. To address this issue, an initial comparison of gene expression in the mutants was made by the Differential Display technique. An analysis of approximately 20% of the mRNAs in these cells revealed eight differences between wild type and the two mutants. None of the alterations were shared by both mutants. These data reveal that the mutations underlying the similar phenotypes observed in CH-Kr and C2.2 are, in fact, dramatically different, and demonstrate the applicability of the Differential Display technique to the study of such mutations.
Ceratocanthus globulus in Germar 1843
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus globulus

description: Ceratocanthus globulus (Erichson, 1843) (in Germar 1843)
Sphaeromorphus globulus Erichson 1843: 117 (in Germar 1843) (Brazil)
Distribution. French Guiana: Paulian 1982: 80; Howden and Gill 2000: 321; Ocampo and Ballerio 2006: 184; Ballerio 2014: 84. Brazil (NA): Erichson 1843: 117 (in Germar 1843) (as Sphaeromorphus globulus); Arrow 1912: 49 (as Acanthocerus globulus); Blackwelder 1944: 218 (as Acanthocerus globulus); Paulian 1982: 80 (NA); Howden and Gill 2000: 321; Ocampo and Ballerio 2006: 184. Other: Paulian 1982: 80 (Colombia); Howden and Gill 2000: 321 (Colombia); Ocampo and Ballerio 2006: 184 (Colombia).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 17, DOI: 10.5281/zenodo.3678492
Biomechanical analysis of acetabular dysplasia: foundations for improved clinical care
Creators: name: Abraham, Christine Louise
Publisher: name: University of Utah
Year: 2015
Subjects: Acetabular dysplasia
Discrete element analysis
Finite element analysis
Hip
Imaging
MRI

description: Altered mechanics are believed to initiate osteoarthritis in hips with acetabular dysplasia. Periacetabular osteotomy (PAO) is the preferred surgical treatment; however, it is unknown if the procedure normalizes joint anatomy and mechanics. Changes in three-dimensional (3D) morphology and chondrolabral mechanics were quantified after PAO. Finite element (FE) models demonstrated that PAO improved the distribution of coverage, reduced stress, increased congruity, and prevented cartilage thinning. However, changes in mechanics were not consistent. In fact, one patient exhibited increased stress after surgery, which was believed to be a result of over-correction. Therefore, methods to integrate morphologic and biomechanical analysis with clinical care could standardize outcomes of PAO. FE simulations are time-intensive and require significant computing resources. Therefore, the second aim was to implement an efficient method to estimate mechanics. An enhanced discrete element analysis (DEA) model of the hip that accurately incorporated cartilage geometry and efficiently calculated stress was developed and analyzed. Although DEA model estimates predicted elevated magnitudes of contact stress, the distribution corresponded well with FE models. As a computationally efficient platform, DEA could assist in diagnosis and surgical planning. Imaging is a precursor to analyzing morphology and biomechanics. Ideally, an imaging protocol would visualize bone and soft-tissue at high resolution without ionizing radiation. Magnetic resonance imaging (MRI) with 3D dual-echo-steady-state (DESS) is a promising sequence to image the hip noninvasively, but its accuracy has not been quantified. Therefore, the final aim was to implement and validate the use of 3D DESS MRI in the hip. Using direct measurements of cartilage thickness as the standard, 3D DESS MRI imaged cartilage to ~0.5 mm of the physical measurements with 95% confidence, which is comparable to the most accurate hip imaging protocol presented to date. In summary, this dissertation provided unique insights into the morphologic and biomechanical features following PAO. In the future, DEA could be combined with 3D DESS MRI to efficiently analyze contact stress distributions. These methods could be incorporated into preoperative planning software, where the algorithm would predict the optimal relocation of the acetabulum to maximize femoral head coverage while minimizing contact stress, and thereby improve long-term outcomes of PAO.
Supplemental_material.docx
Creators: name: Pokorny, Scott
name: Stadnyk, Tricia A.
name: Ali, Genevieve
name: Déry, Stephen
name: Rajtantra Lilhare
Publisher: name: figshare
Year: 2020
Subjects: Hydrology

description: Supplemental materials for the publication: "Use of Ensemble-Based Gridded Precipitation Products for Assessing Input Data Uncertainty Prior to Hydrologic Modeling"
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.12.1961, erstellt von Adnan Kiral an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Functional aspects of Adenomatous Polyposis Coli protein dimerization and posttranslational regulation
Creators: name: Logan, Jennifer Sue
Publisher: name: University of Utah
Year: 2012
Subjects: Adenomatous Polyposis Coli
Peptide Probes

description: The Adenomatous Polyposis Coli (APC) tumor suppressor gene is responsible for an inherited predisposition to colon cancer through the development of multiple colorectal adenomas. Mutations in APC are also found in the majority of sporadic colorectal cancers, indicating that APC function is critical to maintenance of cell growth and differentiation in colonic epithelium. Soon after APC was identified, it was demonstrated that APC protein could form stable, coiled-coil homodimers via a predicted alpha-helical region within the amino terminus of the protein. Because this region of APC is predicted to be preserved in most mutant forms of the protein, it is likely that homodimer formation influences the function of both wild-type and mutant APC protein species. Using several approaches, I examined structural and biological aspects of the coiled-coil APC homodimerization domain. In a collaborative effort with the laboratory of Tom Alber at the University of California, Berkeley, I functionally tested a peptide probe that was designed to dimerize preferentially with the coiled-coil homodimerization domain of wild-type APC protein. The strategic design of peptide probes for APC protein provided the rationale and experimental tools for subsequent investigation into the effects of APC homodimer disruption in vivo.  When expressed in cultured cells, these peptides interacted with endogenous wild-type APC protein in a manner that reflected their in vitro affinities for the wild-type APC dimerization domain; however, a preliminary survey revealed no clear effects of peptide expression upon known functions of APC protein. In addition to studying APC dimerization, I examined potential regulatory relationships between APC, beta-catenin and the ubiquitin-proteasome pathway. These experimental findings agree with published reports that beta-catenin is a substrate for the ubiquitin-proteasome pathway in vivo. Half-life analyses also reveal that wild-type APC protein is extremely stable in vivo, although truncated, mutant APC protein can be regulated by the ubiquitin-proteasome pathway.
Sonnenfleckenzeichnung Nr. 20943.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.12.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
How to make data public: ethics, regulations, solutions
Creators: name: Van Swieten, Maaike M. H.
name: Bjaalie, Jan G.
Publisher: name: Zenodo
Year: 2021
Subjects: Ethics
Data Sharing
Data governance
Human Data
Open Science

description: Data governance is important for ensuring that data are consistent, trustworthy and will not be misused. In this presentation, we focus on the ethical considerations for sharing data, the requirements that are imposed by various regulations, particularly for sharing data from human subjects, and we discuss how services in EBRAINS are designed to deal with the ethical and regulatory aspects of sharing this kind of data.
title: Tapped In: The Rise of Mobile Malware
Creators: name: Davenport, Chrystofuer
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2024

description: As the world of technology continues to evolve and become more advanced with our life, so do the dangers and threats that are determined to hinder that development. Malware continues to be a danger to internet surfers or people with access to technology. At first it was an issue that existed only with computers but since the evolution of smartphones in the early twenty-first century, mobile devices have been a target for multiple malware viruses. It’s important to be aware of what different viruses are capable of doing and how to avoid them when they are encountered. Even though computers and mobile devices have similar functions today, certain malware is designed to specifically target one or the other.
Housing for the aged
Creators: name: Peterson, Lowell S.
Publisher: name: University of Utah
Year: 2013

description: RESOLVED. THAT THE HOUSING OF THE AGED IS AH IMPORTANT SOCIAL PROBLEM OF OUR SOCIETY. A PROBLEM THAT THE ARCHITECTURAL PROFESSION IS GO 111G TO HAVE TO FOCUS IT'S ATTENTION ON, INCREASINGLY, IN THE FUTURE. THAT IT IS A SOCI/.L FACT THAT THIS 3EGMEHT OF OUR POPULATION IS §0 RAPIDLY GROWING IN NUMBERS; BUILDING DESIGN WILL HAVE TO REFLECT IN ITS CREATION THE NEEDS OF AN OLDER POPULATION. THIS AWARENESS OF THE PROBLEMS OF THE AGED SHOULD RESULT IN GENERAL IMPROVEMENT OF Till MAJORITY OF BUIDLIHG DESIGN. TEAT RISING COSTS IN LIVING HAVE CREATED SEVERE PROBLEMS ECONOMICALLY FOR OUR SENIOR CITIZENS, AND THAT WAYS AND MEANS MUST BE FOUND FOR HELPING THEM TO SOLVE THEIR HOUSING NEEDS ADEQUATELY. PROPOSAL. THAT OLDER PEOPLE CAN ENJOY SELF-RESPECT AND A FEELING OF INDEPENDENCE BY PAYING THEIR OWN WAY AS THEY ARE ABLE. THAT WAYS AND MEANS OF HOUSING THE AGED CAN BE ACHIEVED, GIVING THEM PROPER CARE AND ATTENTION WITHOUT CREATING A FEELING OF INSTITUTIONALISM. THAT THIS HOUSING AND CARE CAN BE PROVIDED BY PROPER PLANING AND BY A SOUND FINANCIAL APPROACH.
Ceratocanthus humeralis in Germar 1843
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus humeralis

description: Ceratocanthus humeralis (Erichson, 1843) (in Germar 1843)
Sphaeromorphus humeralis Erichson 1843: 116 (in Germar 1843) (Brazil)
Distribution. Suriname: Paulian 1982: 78; Howden and Gill 2000: 321; Ocampo and Ballerio 2006: 184. Brazil (NA): Erichson 1843: 116 (in Germar 1843) (as Sphaeromorphus humeralis); Blackwelder 1944: 218 (as Acanthocerus humeralis); Paulian 1982: 78 (NA); Howden and Gill 2000: 321; Ocampo and Ballerio 2006: 184. Other: Arrow 1912: 49 (Panama, South America - as Acanthocerus humeralis); Blackwelder 1944: 218 (Panama - as Acanthocerus humeralis); Paulian 1982: 78 (Panama); Howden and Gill 2000: 321 (Panama); Ocampo and Ballerio 2006: 184 (Panama).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 18, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung Nr. 20777.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.06.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 20913.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.11.1961, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Making meaning of the Hmong: a qualitative case study of community discourse in the construction of public opinion
Creators: name: Baker, Sherry
Publisher: name: University of Utah
Year: 2013

description: This case study explores the multi leveled community discourses through which members of the receiving community in Fresno, California, constructed their opinions of Hmong immigrants as evidenced in media and experiential texts. Media frames of the Hmong are identified through close textual analysis in two media texts: a newspaper text consisting of 16 long articles from The Fresno Bee published between 1986 and 1991 and a broadcast text consisting of questionnaires completed by six broadcast professionals in the Fresno area in 1991. The experiential text is comprised of responses to questionnaires distributed in 1991 through the snowball method and returned anonymously by study respondents . Transcript ions of 27 respondents ' self-descriptions of their discursive experiences with and about the Hmong are analyzed through qualitative phenomenological methods . The analysis examines respondents ' personal experience with the Hmong , interpersonal communication with others about them, and media messages to which they were attentive and explores the impact of those discourses on the construct ion of their opinions of the Hmong. The experiential and media texts taken together identify a catalog of ideas and perspectives about the Hmong that existed and circulated through public discourse in the Fresno area. The study concludes that for respondents in this case, public opinion of the Hmong was organized and constructed in interpersonal discourse about them among respondents ' personal and professional associates in their own small -scale interpersonal publics . Opinion was formed within the discursive context of a multileveled network of parallel and intersecting discourses through which information and ideas about the Hmong were shared and transmitted across the community. Diverse community discourses about the Hmong converged in mass media stories and were displayed there , but the media did not set the agenda for or provide the context or dominant frames for discourse about the Hmong for this study's respondents . Personal experience with the Hmong was also less influential in opinion formation than was interpersonal discourse about them. Change in opinion, however , was a result of personal contact and experience with the Hmong. A final dialectic between communication theory and the study's findings results in the suggest ion of a profile for a communication model of public opinion formation that would explain the discursive opinion formation processes identified in this case.
Ceratocanthus major Paulian 1982
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus major

description: Ceratocanthus major Paulian, 1982
Ceratocanthus major Paulian 1982: 96 (French Guiana)
Distribution. French Guiana: Paulian 1982: 96; Howden and Gill 2000: 321; Ocampo and Ballerio 2006: 184; Ballerio 2014: 84.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 18, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung Nr. 20935.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.12.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Oxidized phospholipids activate both platelet-activating factor receptors and peroxisome proliferator-activated receptors.
Creators: name: Davies, Sean S.
Publisher: name: University of Utah
Year: 2012
Subjects: Etiology
Pathology

description: Atherosclerosis leads to about 640,000 deaths every year in the United States and is the leading cause of death in this country. Activation of monocytes by oxidized low-density lipoprotein (LDL) is a critical step in atherosclerosis. Oxidized LDL phospholipids are able to activate the platelet-activating factor (PAF) receptor. This receptor plays a key role in the activation of physiological leukocyte responses and may play a role in the development of atherosclerosis. Oxidized LDL phospholipids are also able to induce monocyte chemotactic protein-1 (MCP-1), another molecule with a critical role in both physiological inflammation and atherosclerosis. This dissertation examines the mechanisms whereby oxidized LDL phospholipids are able to induce responses in monocytes. The first study determined the structural characteristics of the oxidized LDL phospholipids that activate the PAF receptor. These phospholipids were demonstrated to be phosphatidylcholine (PC) that have sn-1 ether bonds, an unexpected result given the relative scarcity of alkylacyl PC in the LDL particle. Several species of oxidized alkylacyl PC were shown to be potent ligands of the PAF receptor. One of these PC was an alkylacyl PC with an eight carbon sn-2 acyl chain modified with an ?-aldehydic residue, 1-O-hexadecyl-2-(8-oxooctanoyl)- sn-glycero-3-phosphocholine. This oxidized PC induced PAF receptor activation at nanomolar concentrations and was as potent as several previously identified PAF analogs. The second study examined the mechanism whereby oxidized LDL phospholipids can induce MCP-1 synthesis by monocytes adherent to an alpha-ICAM-3 antibody surface. On this surface oxidized LDL phospholipids, but not PAF, stimulate MCP-1 secretion. The activation of MCP-1 secretion from monocytes was demonstrated to be independent of the PAF receptor. In the third study, the mechanism of oxidized phospholipid induction of MCP-1 secretion was further examined. Peroxisome proliferator-activated receptors (PPAR) have recently been implicated in the regulation of expression of several proteins thought to be important to the progression of atherosclerosis. Adhesion to the alpha-ICAM-3 surface by monocytes was demonstrated to induce the expression of PPAR-gamma;. PPAR agonists were demonstrated to activate MCP-1 secretion and oxidized phospholipids were themselves demonstrated to be PPAR agonists.
Sonnenfleckenzeichnung Nr. 20934.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.12.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 20928.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.11.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Engagement and struggle for beloved community: old lesbians building community through participatory action research
Creators: name: Abrams, Elizabeth Marie
Publisher: name: University of Utah
Year: 2014
Subjects: Aging
Beloved community
Feminist
Lesbian
LGBT
PAR

description: The remarkable increase in the last 15 years of published literature on LGBT people has typically used mixed samples of gay men and lesbians, even though differences in historical, political, and social contexts lead each reference group to have unique lived experiences and needs. Kehoe (1988) stated that old lesbians are "triply invisible" due to the intersections of at least three marginalized statuses - old, female, and lesbian. With rich legacies of activism, old lesbian communities can draw on their radical roots to continue improving the lives of old lesbians in the future. Participatory action research (PAR) includes research participants as coresearchers and relies on the wisdom and knowledge of the members of a marginalized community to follow the best course of action for social change in their community. This study documented the process by which old lesbians in the Living Our Visions PAR group in Salt Lake City, Utah, created community and engaged in social change. The research goals were: (a) to serve as a catalyst for old lesbians to meet, organize, and identify goals for their community that would enhance wellbeing and to embark on action to achieve stated goals; (b) to document the activities of the group by actively engaging in the plan-act-observe-reflect cycle of PAR; and (c) to serve as a model for community building and action for other old lesbian communities.
Sonnenfleckenzeichnung Nr. 20912.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.11.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Potency and Pharmacokinetic Enhancement of D-Peptide HIV-1 Entry Inhibitors
Creators: name: Redman, Joseph Stapley
Publisher: name: University of Utah
Year: 2013

description: Peptides are a powerful class of therapeutics with high potency, high specificity, low immunogenicity, and effective methods of discovery. However, peptides often possess limitations including degradation by proteases, rapid clearance by renal filtration, and difficulty passing through membranes. The Kay lab at the University of Utah has applied the benefits of peptide design to tackling the problem of HIV-1 transmission. In this dissertation I describe the discovery of our lead peptide candidate, PIE12, including its optimization by mirror-image phage display, its potency enhancement by defined geometric linkages and lipid conjugation, its engineered ability to prevent HIV-1 resistance, and finally the optimization of its pharmacokinetic properties. These efforts have overcome the common limitations of peptide therapeutics and produced an ideal preclinical candidate for the treatment and prevention of HIV/AIDS. The first chapter examines the scope of the HIV pandemic, describes HIV-1's susceptible target for which we developed PIE12, and includes a brief examination of the current state of the peptide therapeutic field. The second chapter reviews methods of peptide discovery that enable protease resistance, including a discussion of well-validated techniques like mirror-image phage display followed by a review of several emerging technologies. The third chapter reveals how the aforementioned techniques were utilized in the discovery of PIE12, including early efforts to link PIE12 peptides together in order to improve potency. The fourth chapter completes this story, illuminating our efforts to optimize the linkages between PIE12 peptides in order to increase potency, and includes information on potency-enhancing membrane-tethering moieties. The fifth chapter describes our efforts to make potent PIE12-conjugates suitable for subcutaneous delivery, including new conjugate designs and detailed evaluation of their half-life-improving properties. The final chapter discusses future directions and new opportunities revealed to us by the body of this work. iv
Creating a shared history: serial narratives in The young woman's journal, 1889-1894
Creators: name: Baker, Sherry
Publisher: name: University of Utah
Year: 2013

description: Creating a Shared History: Serial Narratives in The Young Woman's Journal, 1889-1894 is a cultural press history and textual analysis of contemporary indigenous serial literature in a nineteenth-century Mormon young women's periodical. It tests press historian Catherine Covert's assertions that some of the functions of the press are (1) to be a conservator of values, and (2) to engender harmony and affiliation among community members. The investigator places the Journal within the historical/ cultural context from which it was written, and identifies specific messages in the serial narratives that encouraged the preservation of Mormon values and Mormon community affiliation. The author gives a brief overview of Utah press history, discusses the social and historical forces that shaped nineteenth-century Mormon women, reviews the history of the Journal and its editor, Susa Young Gates, and analyzes the text of the Journal's first five years of serial narratives. Some of the major affiliative themes were recitations of personal and group suffering and sacrifice for the religion; empathy for Mormons of other generations and nationalities; defense of Mormon theology and lifestyle; and encouragement to marry within the Church. Positive depictions of polygamy continued in the stories, even after Mormon leaders issued a public announcement that plural marriage would no longer be sanctioned. The tone of the narratives was ardently defensive of polygamy, and of plural wives, as if they had been written for the benefit of Mormon foes. Inasmuch as they were written exclusively for an audience of young Mormon women, however, many of whom were products of plurality, the defensive stance is notable. Despite recent studies that document continued Mormon participation in and allegiance to polygamy, this author suggests a disenchantment with the practice, at least among young Mormon women. As Covert's assertions would predict, the messages of the Journal's narratives sought to reduce that disenchantment and alienation and to foster bonding with the community. Covert's assertions about the functions of the press are well supported by all aspects of this study. The thesis is also evidence that contemporary indigenous literature is a rich source of cultural history.
Machine learning meets condensed matter
Creators: name: Howard, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Condensed Matter Physics
subject: FOS: Physical sciences
subject: 20403 Condensed Matter Modelling and Density Functional Theory
subject: 20404 Electronic and Magnetic Properties of Condensed Matter; Superconductivity
subject: 20402 Condensed Matter Imaging
subject: 20405 Soft Condensed Matter
subject: 20401 Condensed Matter Characterisation Technique Development
subject: 20499 Condensed Matter Physics not elsewhere classified
subject: 20406 Surfaces and Structural Properties of Condensed Matter
subject: 10506 Statistical Mechanics, Physical Combinatorics and Mathematical Aspects of Condensed Matter
subject: FOS: Mathematics

description: Published in The Startup
Ceratocanthus seriatus in Germar 1843
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus seriatus

description: Ceratocanthus seriatus (Erichson, 1843) (in Germar 1843)
Sphaeromorphus seriatus Erichson 1843: 124 (in Germar 1843) (Brazil)
Distribution. French Guiana: Paulian 1982: 87; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184; Ballerio 2014: 84. Brazil: Erichson 1843: 124 (in Germar 1843) (as Sphaeromorphus seriatus); Arrow 1912: 49 (as Acanthocerus seriatus); Blackwelder 1944: 218 (as Acanthocerus seriatus); Paulian 1982: 87; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184. Other: Paulian 1982: 87 (Peru); Howden and Gill 2000: 322 (Peru); Ocampo and Ballerio 2006: 184 (Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 18, DOI: 10.5281/zenodo.3678492
Initial information sources about valium.
Creators: name: Robison, Tanya Fern
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Valium
subject: Nursing
subject: FOS: Health sciences

description: Increased use of Valium during the past two decades has resulted in Valium being the most commonly prescribed drug in the United States (Blackwell, 1973).  Increased stress placed upon individuals in today's society has pressured them into seeking alternatives that will aid with the relief of stress, anxiety and tensions.  One alternative has been use of Valium.  This investigation was designed to evaluate from what initial information source Valium users learn of the drug and initiate its use.  The conceptual framework for the study was based upon the "demon theory," that the organism is sick because it has been invaded, damaged, or depleted by a foreign element or demon (French, 1977).  Stress is the conceptual element that has invaded and damaged the organism.  Stress, moves the organism away from homeostasis for a time and with sufficient force to prohibit the organism from reestablishing balance easily.  An organism must be able to adapt to a disturbing force such as stress, by bringing the disturbance under control (assimilation) with such help as Valium or by modification to meet the new demands (accommodation).  The instrument used was a questionnaire designed by the investigator.  The principle analysis was frequency distributions and percentages.  The most common initial information source and supplier of Valium was a physician or supervised assistant.  The reasons for using Valium were obtained from the initial supplier by detailing pertinent information about the physical and emotional symptoms manifested by the individual.  Additional findings such as dose, frequency, Valium use, use of other medications, current suppliers or sources, and the need for Valium were shown to be individualized according to present manifestations, adaptation and coping mechanisms.  Further study is recommended with a larger sample from other areas and differing sub cultural groups to evaluate the reliability of the instrument.
A collection of instrument characteristics for all satellites with HIRS/2, HIRS/3 and HIRS/4
Creators: name: Seibert, Constanze
Publisher: name: Zenodo
Year: 2022

description: Instrument properties for all satellites with HIRS/2, HIRS/3 and HIRS/4. Each file lists the meta data of the corresponding satellite, like the central wavelength, the calibration coefficients and the field of view for each infrared channel of HIRS. These values were used for the calculation of the calibrated radiance of the moon.
Procession de la Sanch, Vendredi Saint. Miserere des pendus suivi d'un goigs
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2022

Abstract
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.11.1961, erstellt von Vasile Dinulescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Ceratocanthus suturalis
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus suturalis

description: Ceratocanthus suturalis (Lansberge, 1887)
Acanthocerus suturalis Lansberge 1887: 205 (French Guiana)
Distribution. Suriname: Paulian 1982: 90; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184. French Guiana: Lansberge 1887: 205 (as Acanthocerus suturalis); Paulian 1982: 90; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184; Ballerio 2014: 84. Brazil: Paulian 1982: 90; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184. Other: Arrow 1912 (not mentioned); Blackwelder 1944 (not mentioned); Paulian 1982: 90 (Bolivia, Ecuador, Peru, Trinidad and Tobago); Howden and Gill 2000: 322 (Bolivia, Ecuador, Peru, Trinidad and Tobago); Ocampo and Ballerio 2006: 184 (Bolivia, Ecuador, Peru, Trinidad and Tobago).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 18, DOI: 10.5281/zenodo.3678492
Experience of parenthood for adolescent mothers with toddlers
Creators: name: Ellerbee, Susan Mercedes
Publisher: name: University of Utah
Year: 2012
Subjects: Life Change Events
Child Rearing
Maternal-Child Nursing
Mother-Child Relations
Teenage Parents

description: The purpose of this study was to build a knowledge base about the experience of parenthood for adolescent mothers with toddlers. Objectives were to elicit maternal perceptions of themselves as parents, selected childrearing practices, relationships with kin and significant others, daily routines and lifestyles, and the effect of parenthood on their life. The purposive sample consisted of 12 adolescent mothers, ranging in age from 14 to 21 years, and their children, ranging in age from 24 to 39 months. The variables of maternal age, age and gender of the child guided the sampling plan. The sample represented a cross-section of adolescent mothers with varying degrees of familial and paternal involvement. Focused and open-ended interviews were used to obtain demographic data, plus the mother's perceptions and experiences. The Home Observation for the Measurement of the Environment (HOME Inventory) and Denver Developmental Screening Test (DDST) were administered. Content analysis and similar techniques were used for interview data; descriptive statistics were used for demographic information. A computer program facilitated analysis of the data. Informed consent was obtained from each participant. Five research questions guided data collection and analysis. The maternal role was judged as being successfully attained by 10 informants. No developmental delays were seen among the children. Variations in childrearing practices and lifestyles were congruent with current literature about family structure and function. The impact of early childbearing had conflicting meanings for the mothers. Six themes were generated from the data: Being a teen mom is hard, but I wouldn't change it; Being a teen mom is a special responsibility, but I can do it!; Having your family's help is necessary; Being a mom is every day; Having a baby is a stabilizer; and Don't do it! Variation was noted among respondents for each theme. Existing conceptualizations about adolescent parents were partially supported. Based on this initial study, models of adolescent parenting can be tentatively extended to include parents of toddlers. Suggestions for future research include a comprehensive study of mothers of all ages who have toddlers. Implications for nursing practice emphasize a holistic, individualized approach to care.
Sonnenfleckenzeichnung Nr. 20795.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.07.1961, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Analysis of Extended Pedigrees Ascertained for Asthma
Creators: name: Teerlink, Craig C
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Asthma
subject: Statistics
subject: FOS: Mathematics

description: This dissertation describes statistical analyses of an extended pedigree resource  ascertained for asthma. The asthma pedigree resource contains 741 affected individuals  in 81 pedigrees, with approximately 90 percent of the resource genotyped  on 535 short tandem repeat markers dispersed throughout the genome. As a  motivation for our analysis of the asthma pedigree resource, we first establish  strong evidence for a heritable component to asthma using extensive population  genealogical and phenotypic data from a combined resource of the Utah Population  Database and the Utah death certificate registry. Subsequent analysis of the asthma  pedigree resource itself consisted of various strategies designed to map the genomic  locations of predisposition loci for asthma. First, we conducted a genomewide scan  using a parametric linkage statistic and two general models. We interpreted the  results of the scan using thresholds based on the asymptotic distribution of a related  statistic and concluded that chromosomal region 5ql3 is linked to asthma under a  recessive mode of inheritance. Second, recognizing that the selected thresholds used  to interpret the outcomes of the first scan may be unreliable and that an empirical  evaluation could be informative, we applied the latent p-value method for linkage to  a genomewide scan of the resource. The latent p-value method offers fast empirical  assessment, compared to conventional methods, and the flexibility to consider any  linkage statistic without reference to any theoretical or asymptotic distribution.  The latent p-value analysis confirmed the presence of linkage to chromosome 5ql3,  albeit with a different linkage statistic than was used the in the original genomewide  scan. Third, recognizing that consideration of only two general models may be  insufficient to adequately model the true mode of inheritance at a linked locus, we  conducted another genomewide scan using the modscore statistic, with the benefit  of empirical assessment from the latent p-value method. The mod score analysis exhibited very low power to detect linkage and did not identify any new loci of  interest. Taken together, our analyses indicate that there is linkage in this resource  to chromosomal region 5ql3 and further expansion of this resource is warranted.
Altmetrics compared with traditional citation metrics in the anesthesiology literature — a prospective cross-sectional study
Creators: name: Jones, Philip
name: Chu, Jessica
name: Shin, Sae
name: Lin, Caroline
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Anesthesiology
subject: Medicine and Health Sciences
subject: Medical Specialties

description: A meta-research study of Altmetrics versus traditional citation counts in the top 5 general anesthesiology journals (by their Impact Factor).
Sonnenfleckenzeichnung Nr. 20786.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.06.1961, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.07.1961, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Ceratocanthus undulatus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hybosoridae
Ceratocanthus
Ceratocanthus undulatus

description: Ceratocanthus undulatus (Harold, 1874)
Acanthocerus undulatus Harold 1874b: 38 (Brazil)
Distribution. French Guiana: Paulian 1982: 74; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184; Ballerio 2014: 84. Brazil: Harold 1874b: 38 (as Acanthocerus undulatus); Arrow 1912: 49 (as Acanthocerus undulatus); Blackwelder 1944: 218 (as Acanthocerus undulatus); Paulian 1982: 74; Howden and Gill 2000: 322; Ocampo and Ballerio 2006: 184.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 18, DOI: 10.5281/zenodo.3678492