cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 2: Supplementary Fig 1. Identification of lnc-OXAR as an OXA resistance–related lncRNA in NASH-HCC. (A) Representative images of tumor burden post-intrahepatic injection (Huh-7) for orthotopic HCC mice fed a control diet or western diet using in vivo bioluminescent imaging. And measurement of tumor burden weekly. (B) HE IHC staining of Ki67 and γH2AX in the tumors. Representative images of four xenografts from each group are shown. Scale bar = 50 μm. (C) Heat maps displaying the RNA-seq profiles and supervised hierarchical clustering analysis for OXA-S and OXA-R HCC patients. Significantly differentially expressed transcripts matching the threshold (more than 2- fold difference) and the statistical analysis standard adjusted P value < 0.05 were selected. (D) Volcano plot shows the differentially express genes identified from RNA-seq analysis of HCC patient samples treated with OXA-based HAIC (OXA-S VS OXA-R). (E) Volcano plot shows the differentially express genes identified from RNA-seq analysis of HCC patient samples (NASH HCC VS Non-NASH HCC). (F) Schematic representation of the generation of OXA-R cell line. (G) The relative viability curves of MHCC-97H cells in OXA-P and OXA-R cells treated with different concentrations of oxaliplatin for 48h. (H) Apoptosis analysis of the apoptotic cells in OXA-P and OXA-R MHCC-97H cells under the treatment of OXA (20 μM, 48h).
INNOVATIVE TECHNOLOGIES AND MODERN METHODS IN FOREIGN LANGUAGE TEACHING
Creators: name: Olimzoda, Parvina
Publisher: name: Zenodo
Year: 2024

description: Innovative phenomena cause the transition from the knowledge paradigm of the pedagogical process to the individual, from the "communicators" - to the interactive methods of teaching. All of the above, as well as the need to find ways to intensify the use of innovative teaching methods in the teaching of English at school in the context of the ever changing realities of modern society and its active development, determine the urgency of the work and determine the choice of its’ topic. The problem of teaching foreign languages in school today certainly requires a systematic analysis of speech-activity from psycholinguistic, linguistic and psychological positions. Traditional methods of teaching a foreign language involve the assimilation of knowledge in artificial situations, so that a future graduate does not see the connection of the subject under study with his future professional activity.
Unveiling Multiple Agn Activity With Multi Wavelength Observations
Creators: name: De Rosa, Alessandra
name: Bianchi, S.
name: Bogdanovic, T.
name: Heidt, J.
name: Herrero-Illana, R.
name: Husemann, B.
name: Komossa, S.
name: Loiseau, N.
name: Guainazzi, M.
name: Paragi, P.
name: Pérez-Torres, M.
name: Piconcelli, E.
name: Vignali, C.
Publisher: name: Zenodo
Year: 2018
Subjects: Active Galactic Nuclei
AGN
galaxies: interactions
X-rays: general

description: In this talk we will present results from the MAGNA (Multiple AGN Activity) project focused on the detection and study of multiple supermassive black hole systems. We investigate the physical properties (accretion rate and local environment) of multiple AGN candidates in interacting systems with respect to isolated sources with the goal to understand the mechanisms that trigger AGN activity in different stages of galaxy mergers.

We report on an optical and X-ray study of an optically selected sample of four dual AGN systems at projected separations of 30–60 kpc.

We compare the absorption properties in our dual AGN with those in larger samples observed in X-rays but selected in different ways (optical, IR and hard X-rays). We find that the obscured (NH~1022 cm-2) AGN fraction within the larger sample is 84\pm4 per cent (accounting for the 90 per cent error on the NH measure) up to large pair separations (100 kpc). i.e. statistically higher with respect to the fraction of obscured AGN in isolated galaxies found in X-ray surveys. This evidence is in agreement with the hypothesis that galaxy encounters are effective in driving gas inflow toward the nuclear region, thus increasing the obscuration. The talk will reflect on broader implications of these findings and will present future perspective.
Innovando En La Gestión Educativa
Creators: name: , García-Peñalvo
Publisher: name: Zenodo
Year: 2018
Subjects: Universidad digital; educación abierta; ecosistemas tecnológicos; pensamiento computacional; Proyecto DEFINES

description: Clase magistral impartida en el contexto de la Unidad I: Gestión de la Tecnología y del Conocimiento, de la asignatura Diseño y Evaluación de Recursos Informáticos del Máster en las TIC en la Educación: Análisis y Diseño de Procesos, Recursos y Prácticas Formativas, los días 6 y 8 de noviembre de 2018 en la Facultad de Educación, Universidad de Salamanca.

Específicamente los temas que se van a abordar son: la universidad digital, la educación abierta, los ecosistemas tecnológicos y el pensamiento computacional.
ADvanCE - AI-powered Dialogues for Conservation of Energy - MSCA Postdoctoral Fellowships 2023
Creators: name: Kacperski, Celina
Publisher: name: Zenodo
Year: 2024

description: This is a rejected submission to the MSCA 2023 along with the evaluation letter. 

Abstract:

To avert climate catastrophe, we all, as European and World citizens, need to move towards sustainable choices. But state of the art informational and motivational feedback approaches are yielding very modest results. Aligning individual needs with accessible, tailored information must be key. Conversational agents (e.g., ChatGPT, Bard) might here play a pivotal role. Leveraging conversational agents' adaptable communication styles and vast knowledge base, we aim to dismantle barriers and empower individuals to choose energy-efficient solutions for their heating and electricity needs. ADVANCE unites expertise in behavioral science, computer science, and artificial intelligence. Its applicant's proficiency in large-scale social surveys of technologies for sustainability harmonizes with the supervisor's expertise in algorithm studies and NLP. The planned study entails a multi-wave, randomized experimental trial, targeting behaviors like the adoption of heating vests, small-scale insulation and smart thermostats. We anticipate that our intervention group, supported by a conversational agent, will better translate pro-environmental motivation into tangible energy-efficient practices. Effects will be compared against those of conventional information and feedback approaches and a control group. By employing NLP techniques to analyze participants' conversations alongside survey data, we will gain profound insights into the factors that facilitate or impede progress toward efficient energy utilization. This research will expand the applicant's proficiency in data science, research competencies, and professional networks, enhancing their career as a researcher in the cross-section between sustainability and novel technologies. A set of recommendations for stakeholders such as researchers, policymakers, think tanks, and tech companies will give insights into the role of conversational agents in prompting energy-efficient behaviors and broader behavior changes.
Additional file 3 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 3: Supplementary Fig 2. lnc-OXAR promoted OXA resistance in NASH HCC. (A) The relative expression of lnc-OXAR in HCC cell lines and MIHA normal human hepatocyte cell line. lnc-OXAR was detected by qPCR and normalized to β-actin. (B) IC50 values of seven HCC cell lines. (C) Scatterplot analyzing the correlation between IC50 values and lnc-OXAR expression levels in the seven HCC cell lines. (D) lnc-OXAR expression in HCC cells transduced with si lnc-OXAR or NC. (E) lnc-OXAR expression in HCC cells transduced with vector or lnc-OXAR OE. (F) The relative viability curves of Huh-7 cells treated with different concentrations of oxaliplatin for 48 h after transfection with siNC and si lnc-OXAR. (G) Cell proliferation was assessed by CCK8 assays in Huh-7 cells transfected with siNC and si lnc-OXAR. (H) Colony formation assays and statistical analysis of Huh-7 cells transduced with siNC or si lnc-OXAR. (I) EdU detection in Huh-7 cells transfected with siNC and si lnc-OXAR with or without OXA treatment. Scale bar = 20μm. (J) The relative viability curves of HepG2 cells treated with different concentrations of oxaliplatin for 48 h after transfection with Vector and lnc-OXAR OE. (K) Cell proliferation was assessed by CCK8 assays in HepG2 cells transfected with Vector and lnc-OXAR OE. (L) Colony formation assays and statistical analysis of HepG2 cells transduced with Vector and lnc-OXAR OE. (M) The effect of lnc-OXAR overexpression on apoptosis in HepG2 cells treated with oxaliplatin (20μM, 48h). (N) EdU detection in HepG2 cells transfected with Vector and lnc-OXAR with or without OXA treatment. Scale bar = 20μm. (O) Representative images of comet assay of HepG2 cells transfected with vector and lnc-OXAR with OXA treatment (20μM, 48h) and quantitative analysis. Scale bar = 20 μm. (P) lnc-OXAR expression in HCC cells transduced with sg lnc-OXAR or NC.
Additional file 4 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 4: Supplementary Fig 3. lnc-OXAR promotes OXA resistance in vivo. (A) The effect of lnc-OXAR KO on the tumor growth of subcutaneously implanted PLC/PRF/5 cells treated with OXA (10 mg/kg) or vehicle control in nude mice (n=5). Scale bars, 1 cm. The tumor weights at the end points and measurement of tumor volumes weekly. GS, glucose saline. (B) The effect of lnc-OXAR KO on the tumor growth of subcutaneously implanted Huh-7 cells treated with OXA (10 mg/kg) or vehicle control in nude mice (n=5). Scale bars=1 cm. The tumor weights at the end points and measurement of tumor volumes weekly. (C) The effect of lnc-OXAR OE on the tumor growth of subcutaneously implanted Huh-7 cells treated with OXA (10 mg/kg) or vehicle control in nude mice (n=5). Scale bars=1 cm. The tumor weights at the end points and measurement of tumor volumes weekly.
Report On Eu Open Science Practices And Transfer Of Knowledge And Skills: [Report Prepared Within The Project Be-Open - Boosting Engagement Of Serbian Universities In Open Science, Under Wp2: Developing And Adjusting Guidelines, Policies, And Incentives]
Creators: name: Kosanović, Biljana
name: Ševkušić, Milica
Publisher: name: Zenodo
Year: 2018
Subjects: open science policies
open access policies
next-generation metrics
open access publishing
institutional repositories
open access mandates
open data
research data management

description: The primary aim of Work Package 2 (Developing and adjusting guidelines, policies, and incentives) of the BE-OPEN project  is to develop national and institutional open science policies that will enable efficient open scientific communication and wide dissemination of publicly funded research outputs. In doing this, project partners and the team implementing WP 2 are to rely on a huge body of documents (primarily recommendations and reports) drafted by the European Commission and national bodies in the European Union (EU) countries, as well as on the knowledge exchange achieved during two study visits conducted as part of the BE-OPEN project: the study visit to the University of Leiden (May 2017) and the study visit to the University of Udine (September 2017). The main purpose of this report is to offer a brief analysis of European Open Access (OA) / Open Science (OS) policies and especially the policies of partner universities, with the aim of identifying optimal solutions for Serbian OA/OS policies at various levels.

The report briefly describes the main characteristics and elements of European OA/OS policies, the lessons learned during the study visits, and explains the elements of the draft of the Serbian Open Science Platform.
description: Project: BE-OPEN (Boosting Engagement of Serbian Universities in Open Science)
Additional file 5 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 5: Supplementary Fig 4. lnc-OXAR maintained Ku70 stability by recruiting CSTA. (A) Enriched GO pathways of lnc-OXAR-binding proteins screened by ChIRP-MS assays (unique peptide ≥2, fold change >1.5). (B) The mRNA level of Ku70 between peritumor and tumor samples in TCGA cohort. (C) The IHC score of Ku70 in paired peritumor and tumor samples (n=228 pairs) in SYSUCC cohort. (D) Overall Survival rate of HCC patients categorized according to median Ku70 expression in TCGA cohort. (E) OS rate of HCC patients categorized according to median Ku70 expression in SYSUCC cohort. (F) RFS rate of HCC patients categorized according to median Ku70 expression in SYSUCC cohort. (G) The distribution of AFP (<400, ≥400) determined by the IHC score of Ku70 in the high or low groups in SYSUCC cohort. p values were determined by two-tailed Chi-square test. (H) The distribution of stage (I-II, III-IV) determined by the IHC score of Ku70 in the high or low groups in SYSUCC cohort. (I) Representative IHC staining images of Ku70 expression HCC tissues. Scale bar = 100 μm. (J) Ku70 RIP-qPCR analysis of lnc-OXAR level in Huh-7 cells. (K) Ku70 RIP-qPCR analysis of lnc-OXAR level in HepG2 cells. (L) Ku70 mRNA level in HCC cells after lnc-OXAR KO. (M) WB showing Ku70 protein in Huh-7 cells with or without lnc-OXAR KO treated with CHX for the indicated time. (N) WB showing Ku70 protein in HepG2 cells with or without lnc-OXAR OE treated with CHX for the indicated time. (O) CSTA RIP-qPCR analysis of lnc-OXAR level in Huh-7 and HepG2 cells. (P) WB results verified that Ku70 associated CSTA. (Q) WB of immunoprecipitated Ku70 and CSTA to determine the effect of lnc-OXAR8 KO on Huh-7 cells. (R) &(S) IF staining showed the co-localization of CSTA (green) and Ku70 (red) in HCC cells. Scale bar = 10 μm. (T) WB showing the effect of CSTA silencing on Ku70 protein in HepG2 cells with or without lnc-OXAR OE after treated with CHX for the indicated time.
Brief an Abraham Trommius
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1717
Subjects: Alting, Menso1637-1713
Bernoulli, Nicolas1695-1726
Braun, Johannes1628-1708
Muyckens, Theodorus1665-1721
OostbroekAdvokat in Groningen
Rossal, Michael1674-1744
Themmen, Phoebus1678-1737
Wichers, Wicher1651-1715

description: Joh. B. teilt Trommius mit, was er wegen der erneuten Berufung nach Groningen an Muykens und Rossal geschrieben hat.
description: von Johann I Bernoulli
description: Eigenhändiges P.S.
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Digitalisierung=Digitization=Numérisation TIFF 06.03.2016
Albert Altorfer
Creators: name: Schellenberg, Johann Rudolf
Publisher: name: [s.n.]
Year: 1770
Subjects: Altdorfer, Albrecht1480-1538

description: [gezeichnet von Johann Rudolf Schellenberg]
description: Seitenrichtige Variante zur Radierung in: Füssli, Johann Caspar. Geschichte der besten Künstler in der Schweiz. Bd. 1. v.d.S. 3
Big and Little Feet Provincial Profiles: Prince Edward Island
Creators: name: Dobson, Sarah
name: Fellows, G. Kent
Publisher: name: The School of Public Policy Publications
Year: 2017

description: This communiqué provides a summary of the production- and consumption-based greenhouse gas emissions accounts for Prince Edward Island, as well as their associated trade flows. It is part of a series of communiqués profiling the Canadian provinces and territories.1 In simplest terms, a production-based emissions account measures the quantity of greenhouse gas emissions produced in Prince Edward Island. In contrast, a consumptionbased emissions account measures the quantity of greenhouse gas emissions generated during the production process for final goods and services that are consumed in Prince Edward Island through household purchases, investment by firms and government spending. Trade flows refer to the movement of emissions that are produced in Prince Edward Island but which support consumption in a different province, territory or country (and vice versa). For example, emissions associated with the production of Prince Edward Island crops that are exported to Nova Scotia for processing and sale are recorded as a trade flow from Prince Edward Island to Nova Scotia. Moving in the opposite direction, emissions associated with the generation of electricity in New Brunswick that is exported to Prince Edward Island for sale to a Prince Edward Island homeowner are recorded as a trade flow from New Brunswick to Prince Edward Island. For further details on these results in a national context, the methodology for generating them and their policy implications, please see the companion papers to this communiqué series: (1) Fellows and Dobson (2017); and (2) Dobson and Fellows (2017). Additionally, the consumption emissions and trade flow data for each of the provinces and territories are available at: http://www.policyschool.ca/embodied-emissions-inputs-outputs-datatables-2004-2011/.
description: The School of Public Policy Publications, Vol 10 (2017)
Big and Little Feet Provincial Profiles: Newfoundland and Labrador
Creators: name: Dobson, Sarah
name: Fellows, G. Kent
Publisher: name: The School of Public Policy Publications
Year: 2017

description: This communiqué provides a summary of the production- and consumption-based greenhouse gas emissions accounts for Newfoundland and Labrador, as well as their associated trade flows. It is part of a series of communiqués profiling the Canadian provinces and territories.1 In simplest terms, a production-based emissions account measures the quantity of greenhouse gas emissions produced in Newfoundland and Labrador. In contrast, a consumption-based emissions account measures the quantity of greenhouse gas emissions generated during the production process for final goods and services that are consumed in Newfoundland and Labrador through household purchases, investment by firms and government spending. Trade flows refer to the movement of emissions that are produced in Newfoundland and Labrador but which support consumption in a different province, territory or country (and vice versa). For example, emissions associated with the production of Newfoundland and Labrador crude oil that is exported to New Brunswick for refining and sale as motor gasoline are recorded as a trade flow from Newfoundland and Labrador to New Brunswick. Moving in the opposite direction, emissions associated with the production of a Quebec manufactured good that is exported to Newfoundland and Labrador for sale are recorded as a trade flow from Quebec to Newfoundland and Labrador. For further details on these results in a national context, the methodology for generating them and their policy implications, please see the companion papers to this communiqué series: (1) Fellows and Dobson (2017); and (2) Dobson and Fellows (2017). Additionally, the consumption emissions and trade flow data for each of the provinces and territories are available at: http://www.policyschool.ca/embodied-emissions-inputs-outputs-datatables-2004-2011/.
description: The School of Public Policy Publications, Vol 10 (2017)
Big and Little Feet Provincial Profiles: Territories
Creators: name: Dobson, Sarah
name: Fellows, G. Kent
Publisher: name: The School of Public Policy Publications
Year: 2017

description: This communiqué provides a summary of the production- and consumption-based greenhouse gas emissions accounts for the Yukon, Northwest Territories and Nunavut, as well as their associated trade flows. It is part of a series of communiqués profiling the Canadian provinces and territories.1 In simplest terms, a production-based emissions account measures the quantity of greenhouse gas emissions produced in the territories. In contrast, a consumption-based emissions account measures the quantity of greenhouse gas emissions generated during the production process for final goods and services that are consumed in the territories through household purchases, investment by firms and government spending. Trade flows refer to the movement of emissions that are produced in the territories but which support consumption in a different province or country (and vice versa). For example, emissions associated with the production of gold in Nunavut that is exported to Quebec for processing and sale are recorded as a trade flow from the territories to Quebec. Moving in the opposite direction, emissions associated with the production of British Columbia natural gas that is sold to a Northwest Territories utility and used to generate electricity for homes in the Northwest Territories are recorded as a trade flow from British Columbia to the territories. For further details on these results in a national context, the methodology for generating them and their policy implications, please see the companion papers to this communiqué series: (1) Fellows and Dobson (2017); and (2) Dobson and Fellows (2017). Additionally, the consumption emissions and trade flow data for each of the provinces and territories are available at: http://www.policyschool.ca/embodied-emissions-inputs-outputs-datatables-2004-2011/.
description: The School of Public Policy Publications, Vol 10 (2017)
Additional file 6 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 6: Supplementary Figure 5. The effect of lnc-OXAR on OXA resistance is dependent on Ku70. (A) Validation of Ku70 KD in PLC/PRF/5 cells. (B) The effect of Ku70 KD on the apoptosis of HCC cells with treatment (20 μM,48h) using flow cytometry analysis of Annexin V staining. (C) The effect of Ku70 OE on the CCK8 assay of lnc-OXAR KO in OXA-R cells without OXA treatment. (D) The effect of Ku70 KD on the CCK8 assay of lnc-OXAR OE in OXA-R cells without OXA treatment. (E) Images of colony formation assays in HCC cells with or without OXA treatment. (F) The effect of Ku70 OE on the apoptosis of lnc-OXAR-KO in OXA-R cells with treatment (20 μM,48h) using flow cytometry analysis of Annexin V staining. (G) The effect of Ku70 KD on the apoptosis of lnc-OXAR-overexpressing in HepG2 cells with treatment (20μM,48h) using flow cytometry analysis of Annexin V staining. (H) The effect of Ku70 OE on the colony-formation of lnc-OXAR KO in OXA-R cells with or without OXA treatment. (I) The effect of Ku70 KD on the colony-formation of lnc-OXAR-overexpressing in HepG2 cells with or without OXA treatment. (J) The effect of Ku70 KD on the EDU assay of lnc-OXAR-overexpressing in HepG2 cells without OXA treatment. Scale bar = 50 μm.
Teach to take care: course for ALS caregivers. Outcomes from a pilot project
Creators: name: Braga, Anna Caroline M.A.
name: Pinto, Anabela Cardoso
Publisher: name: F1000 Research Limited
Year: 2018

description: ALS affects the autonomy and functional capacity of the self-care with high level of complexity. Patients gradually require specialized assistance from a caregiver to perform all their activities of daily living. A holistic care should be provided though a multidimensional support including the physical, psychological, spiritual and emotional issues for patients and their families. The lack of resources with paucity of specialized medical centers is a relevant concern. Providing scientific evidence-based orientations, in an simple language can help the caregivers to cope with the daily challenges.
Interparietal hernia – a rare cause of intestinal obstruction
Creators: name: Loureiro, Ana Rita Mateus
name: Marques, Adriano
name: Constantino, Júlio
name: Casimiro, Carlos
Publisher: name: F1000 Research Limited
Year: 2018

description: The interparietal hernia is a rare condition in which the hernia sac lies between the layers of the abdominal wall. This is the first case report of an interparietal hernia whose sac lies posterior to the rectus abdominis muscle and isn’t related to previous abdominal incisions. The laparoscopic approach can be used for treatment in some cases.
Additional file 7 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 7: Supplementary Fig 6. The effect of lnc-OXAR on OXA resistance is dependent on Ku70. (A) Validation of Ku70 KD in PLC/PRF/5 cells. (B) HE staining and IHC staining of Ki67, Ku70 and γH2AX in the tumors. Representative images of four xenografts from each group are shown. Scale bar = 50 μm.
Additional file 8 of m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Creators: name: Lin, Zhu
name: Huang, Zhenkun
name: Qiu, Jiliang
name: Shi, Yunxing
name: Zuo, Dinglan
name: Qiu, Zhiyu
name: He, Wei
name: Niu, Yi
name: Yuan, Yunfei
name: Li, Binkui
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 8: Supplementary Fig 7. m6A modification mediated lnc-OXAR upregulation in NASH-HCC. (A) lnc-OXAR expression level was detected after treated with 5-AZA in PLC/PRF/5 and Huh-7 cells. (B) lnc-OXAR expression level was detected after treated with TSA in PLC/PRF/5 and Huh-7 cells. (C) lnc-OXAR expression in HCC cells treated with 50 μM DAA or vehicle. (D) mRNA validation of WTAP knockdown in HCC cells. (E) The degradation rate of lnc-OXAR after WTAP silencing in PLC/PRF/5 cells with actinomycin D. (F) The degradation rate of lnc-OXAR after WTAP silencing in Huh-7 cells with actinomycin D. (G) The degradation rate of lnc-OXAR after WTAP silencing in HepG2 cells with actinomycin D. (H) Correlation between lnc-OXAR and WTAP expression in HCC patients from SYSUCC. (I) mRNA validation of six m6A readers’ knockdown in HCC cells. (J) The degradation rate of lnc-OXAR after IGF2BP2 silencing in PLC/PRF/5 cells with actinomycin D. (K) Degradation rate of lnc-OXAR after IGF2BP2 silencing in Huh-7 cells with actinomycin D. (L) Degradation rate of lnc-OXAR after IGF2BP2 silencing in HepG2 cells with actinomycin D. (M) Correlation between lnc-OXAR and IGF2BP2 expression in HCC patients from SYSUCC.
title: "School shootings"
Creators: name: Meris, Cynthia
Year: 2010

description: "School Shootings" sind Ereignisse die viele Menschen erschüttern. Obwohl es Ereignisse sind, über die man objektiv und informierend berichten sollte, tendieren Medien, vor allem die Boulevardmedien dazu solche Ereignisse sensationell aufzubereiten. Ziel dieser Arbeit war es herauszufinden wie österreichische und deutsche Printmedien über den Amoklauf von Winnenden berichtet haben und ob ethische Richtlinien des Journalismus eingehalten wurden. Die Differenzen zwischen Boulevard- und Qualitätszeitungen waren ebenso Gegenstand dieser Untersuchung. Die auserwählten Qualitätszeitungen waren die „Frankfurter Allgemeine Zeitung“ und der „Standard“ sowie die Boulevardblätter „Bild-Zeitung“, „Bild am Sonntag“ und die „Kronen-Zeitung“. Im ersten Teil der vorliegenden Arbeit wurden Begriffserklärungen und einen Forschungsüberblick über das Phänomen „School Shootings“ präsentiert. Die Nachrichtenforschung und Nachrichtenwerttheorien erklären, warum über Ereignisse wie Amokläufe berichtet wird. In weiterer Folge wurde die Ethik im Journalismus dargestellt. Das Kapitel „Rechtliche Grundlagen der Printmedien“ stellt die publizistischen Grundsätze des Journalismus in Deutschland und Österreich vor und das Kapitel „Boulevard- und Qualitätszeitungen“ zählt die Merkmale der entsprechenden Zeitungen auf, die für diese Arbeit relevant waren. Die empirische Untersuchung wurde anhand einer Kombination aus qualitativer und quantitativer Inhaltsanalyse durchgeführt. Der Untersuchungszeitraum reichte vom 12. März bis zum 19. März 2009. Die Inhaltsanalyse stützte sich auf ein Kategorienschema, welches zuvor aufgestellt wurde. Die Analyse der Berichterstattung hat ergeben, dass es Unterschiede zwischen der deutschen und österreichischen Berichterstattung gibt. So zeigen die Ergebnisse, dass der Amoklauf von Winnenden in der „Bild-Zeitung“ und „Bild am Sonntag“ einen sehr hohen Stellenwert besitzt und darüber sensationell und emotional berichtet wurde, während die „Kronen-Zeitung“ ihre objektive Informationspflicht erfüllt und ethische Grundsätze eingehalten hat. Auch für die „Frankfurter Allgemeine Zeitung“ und der „Standard“ hat der Amoklauf von Winnenden einen hohen Informationswert. Allerdings hat die „Frankfurter Allgemeine Zeitung“ mehr über den Amoklauf berichtet, als der „Standard“. Der höhere Informationswert des Amoklaufes für die deutsche Presse lässt sich aufgrund des Faktors „Nähe“ erklären, da sich der Amoklauf in Deutschland und nicht in Österreich ereignet hat.
Additional file 1 of Transcription factor TaNF-YB2 interacts with partners TaNF-YA7/YC7 and transcriptionally activates distinct stress-defensive genes to modulate drought tolerance in T. Aestivum
Creators: name: Zhao, Ying-Jia
name: Ma, Chun-Ying
name: Zheng, Meng-Jing
name: Yao, Yan-Rong
name: Lv, Li-Hua
name: Zhang, Li-Hua
name: Fu, Xiao-Xin
name: Zhang, Jing-Ting
name: Xiao, Kai
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1
AMELIORATIVE EFFICACY OF ZINGERONE ON LEAD ACETATE INDUCED NEPHROTOXICITY IN WISTAR RATS
Creators: name: Akitha. S
name: Raj Kumar. D
name: Karthik Ganesh Mohanraj
Publisher: name: Zenodo
Year: 2024
Subjects: Lead Acetate, Zingerone, Nephrotoxicity, Antioxidant, Anti-Inflammatory Activity, Environment, Pollution, Disease.

description: Abstract

Background: Lead is one of the heavy metals and considered as a dangerous environmental pollutant. It may be toxic to living beings when ingested directly or indirectly affecting the system as a whole and or organs individually such as liver and kidney. Ginger scientifically referred as Zingiber officinale of the family “zingiberaceae” and has important active ingredients such as zingerone, gingerol, paradol, etc. Zingerone has anti-inflammatory, antioxidant, anti-diabetic and anti-cancer activity. Aim of the work is to elucidate the protective effectiveness of zingerone against lead acetate induced nephrotoxicity in wistar rats. Aim: The aim of work is to research and analyse the antioxidant property of zingerone upon lead acetate induced renal toxicity in rats. Materials and Methods: Male adult rats of Wistar strain were separated into three groupings. Group I: Control, Group II: Lead acetate induction, given at a dose of 0.15% aqueous solution of lead acetate for 60 days and Group III: zingerone treatment (200 mg/kg body weight) daily for 30 days after lead induction period. At the termination of the study period, rats were euthanized, kidney tissues were taken out and processed for biochemical assay to decipher SOD, MDA, urea and creatinine levels and histopathological analysis. Results: Mean SOD level in Group I was 86.00 ± 2.09 U/ml, in Group II was 52.38 ± 3.21 U/ml and in Group III was 67.98 ± 2.78 U/ml. Mean MDA level in Group I was 6.48 ± 0.48 nmol/ml, in Group II was 19.11 ± 3.23 nmol/ml and in Group III was 12.95 ± 2.78 nmol/ml. Mean serum urea level in Group I was 32.71 ± 0.67 mg/dL, in Group II was 48.26 ± 1.87 mg/dL and in Group III was 41.28 ± 1.32 mg/dL. The mean serum creatinine level in Group I was 0.83 ± 0.01 mg/dL, in Group II was 1.92 ± 0.23 mg/dL and in Group III was 1.05 ± 0.03 mg/dL. Histopathological analysis showed severe renal steatosis in Group II compared to Group I control and reduced pathological features in Group III. After zingerone treatment, Group III revealed remarkable recovery from renal damage structurally. Conclusion: It was deciphered that zingerone revealed a tremendous antioxidant efficacy neutralising free radicals against lead acetate induced nephrotoxicity in rat models. Moreover the compound is a natural plant product and thus found to be a remedial agent for kidney metal toxicity at an in vivo scenario without any contra effects.
Additional file 2 of Transcription factor TaNF-YB2 interacts with partners TaNF-YA7/YC7 and transcriptionally activates distinct stress-defensive genes to modulate drought tolerance in T. Aestivum
Creators: name: Zhao, Ying-Jia
name: Ma, Chun-Ying
name: Zheng, Meng-Jing
name: Yao, Yan-Rong
name: Lv, Li-Hua
name: Zhang, Li-Hua
name: Fu, Xiao-Xin
name: Zhang, Jing-Ting
name: Xiao, Kai
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 2
Macrobrachium rosenbergii De Man 1879
Creators: name: Hanamura, Yukio
name: Imai, Hideyuki
name: Lasasimma, Oulaytham
name: Souliyamath, Pany
name: Ito, Sayaka
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Palaemonidae
Macrobrachium
Macrobrachium rosenbergii

description: Macrobrachium rosenbergii (De Man, 1879)
Palaemon d’Acqueti Sunier, 1925: 117.
Macrobrachium rosenbergii: Jayachandran 2001: 158, figs. 11, 12: Hanamura et al. 2008: 1144, figs. 1, 2. Macrobrachium rosenbergii dacqueti: Holthuis 1995: 148; Cai & Ng 2002: 78; Cai et al. 2004: 582. Macrobrachium dacqueti: Wowor & Ng 2007: 326, figs. 4, 5b–c, 6, 7b, 9, 10. Macrobrachium rosenbergii: Ng & Wowor 2011: 66 –67.
Material examined. Champasak Province. Morning market at Pakse city, 1 femele (CL 66.5 mm), 1 ovig. female (CL 58.5 mm), 12 July 2009, coll. S. Ito et al.
Remarks. Macrobrachium rosenbergii is one of the best-known freshwater prawns in the world. The identity of two distinct geographical populations (eastern and western forms) have long been a subject of taxonomic and nomenclatural controversy, although the results of morphological and DNA analyses have suggested that they could be different species (Wowor & Ng 2007, 2008). The present specimens well fit the morphological characteristics of the western form, currently as M. rosenbergii (see ICZN 2010; Ng & Wowor 2011), by having a marked rostral crest and smooth inter spine surfaces on the second pereopods as well as the absence of the posterior submedian plate on the fourth thoracic sternite (Wowor & Ng 2007).
Distribution. Macrobrachium rosenbergii is originally distributed in southern Asia (Jayachandran 2001) and the western part of south-eastern Asia, demarcated by the Huxley’s line (de Bruyn et al. 2004; Wowor & Ng 2007; Ng & Wowor 2011), although it has occasionally been reported outside of its natural habitat as a consequence of human introduction. The presence of M. rosenbergii in southern Laos is believed to be derived from aquaculture ponds of this species in north-eastern Thailand. Recently, colonisation of this species was found in Madagascar (Hanamura et al. 2008).
description: Published as part of Hanamura, Yukio, Imai, Hideyuki, Lasasimma, Oulaytham, Souliyamath, Pany & Ito, Sayaka, 2011, Freshwater prawns of the genus Macrobrachium Bate, 1868 (Crustacea, Decapoda, Palaemonidae) from Laos, pp. 1-37 in Zootaxa 3025 on page 20, DOI: 10.5281/zenodo.204065
title: Theoretisierung der Photographie
Creators: name: Kamenski, Alexander
Year: 2010

description: Die vorliegende Arbeit befasst sich mit den konstitutiven Wesensmerkmalen des photographischen Bildes. Das Photo ist für die Kommunikationswissenschaft von zentraler Bedeutung. Dennoch werden seine Merkmale meist als unbefragte Voraussetzung hingenommen. Ausgehend vom Linguistic Turn und Iconic Turn, der Wende zum Sprachlichen bzw. zum Bildlichen, werden die Kommunikationsmedien Text bzw. Bild und ihre komplementären Potentiale untersucht. Daran anschließend wird die Relevanz der Photographie innerhalb der Kommunikationswissenschaft und des Fachbereichs Visuelle Kommunikationsforschung aufgezeigt. Dabei rückt das Photo als Bildkategorie und Medium ebenso in den Focus der Untersuchung wie seine Verwendung in Kommunikationsprozessen. Den Kern der Arbeit bildet die Erforschung der von Walter Benjamin, Roland Barthes und Charles Peirce theoretisierten Aspekte der Photographie. Aus ihnen werden die konstitutiven Wesensmerkmale des photographischen Bildes (Referentialität, Relativität, Subjektivität, Reduktion, Technik) herausgearbeitet. Hierbei findet auch die Digitalisierung Beachtung. Als technische Komponente beeinflusst sie die Produktion, Distribution und Rezeption von Bildern – drei Bereiche, deren Erforschung sich die Kommunikationswissenschaft widmet.
Git Going With Lego: Tactile Techniques For Teaching Text-Based Tools
Creators: name: Brooks-Kieffer, Jamene
name: Albin, Tami
Publisher: name: Zenodo
Year: 2018
Subjects: Git
Software Carpentry
LEGO
LEGO Serious Play
command line interface
collaboration
scholarly communication
instruction

description: Git is arguably an essential tool of modern scholarship and research communication. It offers robust, distributed version control and mechanisms for collaboration and sharing through online platforms such as GitHub. Yet, Git is obtuse, abstract, and a challenge to both teach and learn. Even well-designed lessons such as those offered by The Carpentries (https://carpentries.org/) put novice learners in situations of potential cognitive overload as they work to understand the processes behind fundamental commands like git init, git add, and git commit. Creating a mental model of Git's functions without assistance from tangible examples is error-prone and may result in confusion, frustration, and discouragement. Enter LEGO. Novice learners can manipulate LEGO to build their understanding of Git's functions at the same time that they are learning the commands that make these functions happen. Jamene, a Carpentries instructor, and Tami, a LEGO Serious Play facilitator (http://seriousplay.training/), will engage FORCE2018 attendees with a hands-on-your-LEGO demonstration of teaching Git with tactile materials. While playing with LEGO, we will:

	Acknowledge characteristics of text-based tools that intimidate and challenge novice learners
	Participate in the use of tactile materials for teaching and/or learning text-based tools
	Consider teaching text-based tools with tactile materials to support learners in moments when they are overwhelmed by new information
Additional file 1 of Subspecialty physicians’ perspectives on barriers and facilitators of hepatitis C treatment: a qualitative study
Creators: name: Bredenberg, Erin
name: Callister, Catherine
name: Dafoe, Ashley
name: Holliman, Brooke Dorsey
name: Rowan, Sarah E.
name: Calcaterra, Susan L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Tante Luise's Vereinli
Creators: name: Lenz, Dominik
Publisher: name: [s.n.]
Year: 1867
Subjects: Frauenverein

description: Gruppenfoto des Vereins "Tante Luises Vereinli"
description: Photographisches Atelier D. Lenz Frankenstrasse No. 124 auf Dorf & Neustadt Zürich
description: Handschriftliche Notizen in Feder zu den dargestellten Frauen
description: Datierung gemäss den bekannten Wirkungsdaten des Fotografen Dominik Lenz
Brief an Giuseppe Verzaglia
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1706
Subjects: Bernoulli, Jakob1655-1705
Hermann, Jacob1678-1733
Leibniz, Gottfried Wilhelm1646-1716
Scheuchzer, Johann1684-1738

description: Joh. B. beantwortet den Brief von Verzaglia von 1706 04 13 wegen seiner schlechten Gesundheit erst jetzt. Er freut sich, dass es auch in Italien Gelehrte gibt, denen seine Forschungen von Nutzen sind. Wenn er weiss, dass seine Briefe sicher an Verzaglia gelangen, wird er ihm ausführlicher schreiben. Aus einem Brief von Johann Scheuchzer an Hermann hat er erfahren, dass Verzaglia daran denkt, nach Basel zu reisen. Er wird in mündlichem Unterricht in ein paar Wochen mehr lernen als in einer jahrelangen Korrespondenz. Verzaglia hat die Reihe aus AE 1694, p.437 sehr elegant zur Integration von x(expm)log(x[expn]dx angewendet. Er hätte auch seine Aufsätze in AE 1697, p.125 und anderswo konsultieren könne. Joh. B. weisst dann auf einen Schreibfehler in Verzaglias Rechnung ihn und schliesst weitere kritische Bemerkungen bezügliche mehrerer Beispiele an. Über eine spezielle Methode zur Kurve schnellsten Abstiegs hat Joh. B. noch nichts publiziert [ev. Op. LXXV]. Über die Fragen zur Velaria, Catenaria und die von seinem Bruder einst gefundenen Lösungen der beiden Gleichungen wird er Verzaglia später unterrichten. Hermann erwidert die Grüsse. P.S. Joh. B. würde sich über Informationen zu mathematischen Neuerscheinungen in Italien freuen.
description: von Joh[ann] I Bernoulli
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Digitalisierung=Digitization=Numérisation TIFF 06.03.2016
Additional file 2 of Subspecialty physicians’ perspectives on barriers and facilitators of hepatitis C treatment: a qualitative study
Creators: name: Bredenberg, Erin
name: Callister, Catherine
name: Dafoe, Ashley
name: Holliman, Brooke Dorsey
name: Rowan, Sarah E.
name: Calcaterra, Susan L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2
Primaarne kusitivähk – kirjanduse lühiülevaade ja haigusjuhu kirjeldus
Creators: name: Niibek, Maris
name: Kivi, Martin
Publisher: name: Eesti Arst
Year: 2018

description: 58aastane naine pöördus günekoloogi vastuvõtule valutu sõlmekesega kubemes. Lümfisõlme biopsial oli tegemist lamerakulise vähi metastaasiga, mille algkollet ei leitud. Onkoloogide konsiiliumi otsusel määrati vaagnapiirkonna regionaalsete lümfisõlmede kiiritusravi. Umbes aasta pärast esmast visiiti avastati regulaarsel günekoloogilisel kontrollil patsiendi kusiti avas polüüpjas moodustis, mille histoloogiline uuring kinnitas lamerakulise vähi diagnoosi. Uretrektoomia järel rajatud epitsüstostoom põhjustas patsiendil kusepõie väljakannatamatut ärritust, mistõttu tehti tsüstektoomia ja rajati Brickeri juha uriini eemaldamiseks. Primaarne kusitivähk on väga harva esinev urotraktikasvaja, mille sümptomite varieeruva väljenduse tõttu võib olla haigus raskesti diagnoositav.
description: Eesti Arst, 2018: Oktoober
Architectura Turicensis
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1881
Subjects: Stadler, Ferdinand1813-1870
Lasius, Georg1835-1928
Rahn, Johann Rudolf1841-1912
Gladbach, Ernst1812-1896
Werdmüller, Johann Konrad1819-1892

description: Porträts von Architekten, Professoren, Künstler, Kunsthistoriker und weitere Kunstschaffende (Lehmann, Moser, Broilley, Roth, Stierlin, Günthard, Gayla, Wirz, Römer, Brügger, Imhof, Schröter, Gull, Stadler, Stamm, Volhard, Meili, Gujer, Stoecklin, Münch, Wernli, Barth, Zehnder, Weber). In der Mitte hervorgehoben abgebildet sind Prof. Stadler, Prof. Lasius, Prof. Rahn, Prof. Werdmüller, Prof. Plunschli und Prof. Gladbach
description: Anonyme Fotografie
Outflows Vs Star Formation In Nearby Agn From The Magnum Survey
Creators: name: Venturi, Giacomo
name: Marconi, A.
name: Mingozzi, M.
name: Nardini, E.
name: Carniani, S.
name: Maiolino, R.
name: Cresci, G.
name: Et Al.
Publisher: name: Zenodo
Year: 2018
Subjects: Active Galactic Nuclei
AGN
outflows
star formation
integral field spectroscopy
NGC 1365
NGC 6810

description: AGN outflows are believed to play a major role in shaping the properties of host galaxies, by sweeping away the gas and quenching star formation (negative feedback). In this framework our MAGNUM survey aims at investigating in detail the interplay between AGN activity and star formation processes in nearby active galaxies which, due to their vicinity, are the ideal laboratories to carry out such a study. The sample comprises ten famous nearby Seyfert galaxies so far, such as Circinus, NGC 1365 and NGC 4945. Thanks to its unique combination of large field of view and spectral coverage, MUSE at VLT allowed us to map the ionised gas down to ~10 pc in several nebular emission lines revealing ubiquitous kpc-scale outflows, whose properties (e.g. velocity, mass outflow rate, kinetic rate etc...) as a function of distance from the active nucleus were measured. By matching MUSE with Chandra X-ray observations we studied the ionized gas and the outflow kinematics and energetics in its different phases and spatial scales in NGC 1365, and obtained unique insights on the properties of the outflows and of the ISM. Additionally, we recently found evidence of a new mode of star formation, occurring within a starburst outflow itself, as predicted by recent models.
Additional file 1 of Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression
Creators: name: Rabl, Miriam
name: Zullo, Leonardo
name: Lewczuk, Piotr
name: Kornhuber, Johannes
name: Karikari, Thomas K.
name: Blennow, Kaj
name: Zetterberg, Henrik
name: Bavato, Francesco
name: Quednow, Boris B.
name: Seifritz, Erich
name: von Gunten, Armin
name: Clark, Christopher
name: Popp, Julius
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Supplementary Material 1