cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Toxognathus costulatus Fairmaire 1878
Creators: name: Rosa, Simone Policena
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Elateridae
Toxognathus
Toxognathus costulatus

description: Toxognathus costulatus Fairmaire, 1878
 (Figs. 9, 10, 34I)
 Toxognathus costulatus Fairmaire, 1878: 271; Schenkling, 1927: 509; Fleutiaux, 1918a: 276; Fleutiaux, 1940a: 35.
 Redescription (male, Fig. 34I): Integument dark brown or dark reddish-brown. Total length 11-12 mm; elytral base as wide as pronotum, elytra 2.7-3.0x longer than pronotum. Frons (Figs. 9D, E) concave medially, frontal carina absent medially. Antennae (Fig. 9A) surpassing posterior angles of pronotum by 2 antennomeres. Mandible unidentate (Fig. 9D). Pronotum (Fig. 9F) flattened 1.15-1.30x wider than long with sides sinuous converging abruptly anteriad on anterior half, lateral carina directed ventrad anteriorly, posterior angles divergent and convex; with punctures less than 0.5 diameter apart. Elytral interstices costate. Free margin of metacoxal plate short and triangular; tibiae widened apicad, dorso apical angle of protibiae acute and produced (Fig. 9J). Tergite IX (Fig. 10D) with anterior margin bisinuous.
 Aedeagus (Figs. 10E, F): Phallobase 0.44x total length of aedeagus, 1.3x longer than wide, length ratio between lateroposterior and median parts 3.1; parameres fused to each other on ventral anteromedian margin; basal strut 0.34x total length of penis; ventral sclerite elliptical.
 Holotype: [Conchinch. (illegible) 1877] [Toxognathus gen. et sp. nov. costulatus, Fairm., Conchonchine] [Toxognathus costulatus Fairm., J. Chassain det. 05] [Muséum Paris, Coll. E. Fleutiaux] male, (MNHN).
 Material examined: VIETNAM. 1 ex. (MNHN). Tay Ninh, 2 exs. (MNHN).
 Distribution: VIETNAM. Tay Ninh.
 Remarks: Toxognathus costulatus is easily recognized by its protibia widened apicad with dorso apical angle acute and produced (Fig. 9J). The parameres with anteromedian margin fused together ventrally is unique to this species.
description: Published as part of Rosa, Simone Policena, 2014, Phylogenetic analysis and taxonomic revision of Physodactylinae (Coleoptera, Elateridae), pp. 217-292 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (18) on page 242, DOI: 10.1590/0031-1049.2014.54.18, http://zenodo.org/record/12641367
Additional file 1: of Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
Creators: name: Soojin Cha
name: Jeongeun Lee
name: Jong-Yeon Shin
name: Kim, Ji-Yeon
name: Sim, Sung
name: Bhumsuk Keam
name: Kim, Tae
name: Kim, Dong-Wan
name: Heo, Dae
name: Se-Hoon Lee
name: Jong-Il Kim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Figure S1. WES pipeline for our study. Figure S2. Pattern-based heuristic annotation to identify driving genetic alterations. Figure S3. Pattern-based heuristic annotation for large-scale samples. Figure S4. Chromosome-level CNVs of AYA cancers from OncoScanâ ˘ and VarScan2. Figure S5. Sequencing validation of RASA2 and NF1 in AYA01 sample. Figure S6. Concurrency of RasGAPs in large-scale studies. Figure S7. EML4-ALK validation in AYA09 cells. (DOCX 50738Â kb)
Toxognathus dohertyi Fleutiaux 1940
Creators: name: Rosa, Simone Policena
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Elateridae
Toxognathus
Toxognathus dohertyi

description: Toxognathus dohertyi Fleutiaux, 1940
 (Figs. 11A, B; 34J)
 Toxognathus dohertyi Fleutiaux, 1940b: 104.
 Redescription (male, Fig. 34J): Integument very bright, evenly light brown. Total length 8.0 mm; elytral base as wide as pronotum, elytra 2.62x longer than pronotum. Frons deeply concave along the anterior margin; frontal carina complete. Antennae surpassing the posterior angles by two antennomeres. Mandible unidentate. Prothorax 1.12x wider than long with sides sinuous converging abruptly anteriad on anterior half; lateral carina prominent posteriorly, directed ventrad anteriorly; posterior angles divergent and convex; pronotum weakly convex with punctures coalescent forming short and irregular longitudinal striae. Elytral interstices convex. Free margin of metacoxal plate short, triangular; tibiae slightly widened apicad, outer angle of protibiae truncate. Tergite IX with anterior margin straight.
 Aedeagus (Figs. 11A, B): Phallobase 0.42x total length of aedeagus, 1.2x longer than wide, length ratio between lateroposterior and median parts 6.1; parameres with ventral anteromedian margin acute, basal strut 0.33x total length of penis; ventral sclerite linear.
 Holotype: [Perak, Malacca (Doherty], [Toxognathus Dohetyi Fleut., Type, Collection Fleutiaux], [Type], [Muséum Paris, Coll. E. Fleutiaux], [Toxognathus dohetyi (Fleutiaux), J. Chassain det. 05], [Lectotype], (MNHN).
 Distribution: MALAYSIA. Perak.
description: Published as part of Rosa, Simone Policena, 2014, Phylogenetic analysis and taxonomic revision of Physodactylinae (Coleoptera, Elateridae), pp. 217-292 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (18) on pages 242-243, DOI: 10.1590/0031-1049.2014.54.18, http://zenodo.org/record/12641367
Additional file 7: Table S6. of Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
Creators: name: Soojin Cha
name: Jeongeun Lee
name: Jong-Yeon Shin
name: Kim, Ji-Yeon
name: Sim, Sung
name: Bhumsuk Keam
name: Kim, Tae
name: Kim, Dong-Wan
name: Heo, Dae
name: Se-Hoon Lee
name: Jong-Il Kim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: RasGAPs in large-scale studies. (PDF 234Â kb)
Additional file 4: Figure S2. of Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems
Creators: name: A. O’Callaghan
name: F. Bottacini
name: M. O’Connell Motherway
name: D. Van Sinderen
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Type I R-M systems of B. longum. A schematic representing the type I R-M system present in B.longum subsp. longum NCIMB 8809, B.breve 12 L, B.longum subsp. longum JCM1217, B.longum subsp. longum F8 and B.longum subsp. longum CCUG 30698. Each arrow represents an ORF. The predicted protein function is indicated as Restriction (Green), Modification (Red), Specificity (Blue), Recombinase (Grey), Hypothetical (White) and Transcriptional regulator (Orange). Target recognition domains (TRDs) are indicated as orange boxes. The percentage amino acid identity is indicated as compared to the B.longum subsp. longum NCIMB 8809 type I R-M. (PDF 11 kb)
MOESM1 of An effective sequence-alignment-free superpositioning of pairwise or multiple structures with missing data
Creators: name: Jianbo Lu
name: Guoliang Xu
name: Shihua Zhang
name: Benzhuo Lu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: 60506 Virology

description: Additional file 1: Table S1. The superposition results of PSSM for two identical protein structures with one randomly generated by a rotation from another one. Table S2. The RMSD of pairwise superposition between 2pka and others with PSSM for Serine Proteinases data set|3rp2b, 1arb, 1ppb, 1sgt, 1ton, 2alp, 2sga, 2snv, 4ptp, 5chab. Table S3. The RMSD of pairwise superposition between 2pka and others with PSSM for Serine Proteinases data set|3rp2b, 1arb, 1ppb, 1sgt, 1ton, 2alp, 2sga, 2snv, 4ptp, 5chab. Table S4. The RMSD of pairwise superposition with PSSM for Fischer's dataset (67 pairs). Table S5. The RMSD of pairwise superposition with PSSM for Fischer's dataset (67 pairs). Table S6. Comparison between PCA+ICP and ICP.
Additional file 3: Table S2. of Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
Creators: name: Soojin Cha
name: Jeongeun Lee
name: Jong-Yeon Shin
name: Kim, Ji-Yeon
name: Sim, Sung
name: Bhumsuk Keam
name: Kim, Tae
name: Kim, Dong-Wan
name: Heo, Dae
name: Se-Hoon Lee
name: Jong-Il Kim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Mutation frequency of WES data for AYA cancers. (PDF 50Â kb)
Immune profile of patients with peritoneal carcinomatosis selected for CRS-HIPEC therapy
Creators: name: Kleber, Julia
name: Yang Zhou, Jordi
name: Weber, Florian
name: Bitterer, Florian
name: Hauer, Patricia
name: Kupke, Paul
name: Kronenberg, Katharina
name: Geissler, Edward K.
name: Schlitt, Hans J.
name: Hornung, Matthias
name: Hutchinson, James A.
name: Werner, Jens M.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Peritoneal carcinomatosis · Colorectal cancer · CRS/HIPEC · Immunotherapy · Memory T cells
subject: 610 Medizin

description: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for peritoneal carcinomatosis (PC) from colorectal cancer (CRC), which is otherwise a terminal stage of disease. Nevertheless, survival outcomes are only marginally superior to other treatments. This fact highlights the need for better strategies to control intra-abdominal disease recurrence after CRS-HIPEC, including the complementary use of immunotherapies. The aim of this study was therefore to investigate the immune phenotype of T cells in patients with PC. Fifty three patients with CRC (34 patients with PC and 19 patients without PC) were enrolled in a prospective study (clinicaltrials.gov: NCT04108936). Peripheral blood and omental fat were collected to isolate peripheral blood mononuclear cells (PBMCs) and adipose tissue mononuclear cells (ATMCs). These cells were analysed by flow cytometry using a panel focused upon T cell memory differentiation and exhaustion markers. We found a more naïve profile for CD8+ T cells in peripheral blood and intra-abdominal fat of PC patients compared to comparator group (CG) patients. Furthermore, there was an over-representation of CD4+ T cells expressing inhibitory receptors in adipose tissue of PC patients, but not in blood. Our description of intraperitoneal T cell subsets gives us a better understanding of how peritoneal carcinomatosis shapes local immune responses.
Additional file 2: Table S1. of Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
Creators: name: Soojin Cha
name: Jeongeun Lee
name: Jong-Yeon Shin
name: Kim, Ji-Yeon
name: Sim, Sung
name: Bhumsuk Keam
name: Kim, Tae
name: Kim, Dong-Wan
name: Heo, Dae
name: Se-Hoon Lee
name: Jong-Il Kim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Sequencing information for WES data. (PDF 95Â kb)
Additional file 1: Figure S1. of Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems
Creators: name: A. OâCallaghan
name: F. Bottacini
name: M. OâConnell Motherway
name: D. Van Sinderen
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Whole genome alignments. Dotplot comparison based on the genomics sequence alignments of B. longum subsp. longum NCC2705 to B. longum subsp. longum NCIMB 8809 and B. longum subsp. longum CCUG 30698. (PDF 240 kb)
Additional file 9: of Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
Creators: name: Soojin Cha
name: Jeongeun Lee
name: Jong-Yeon Shin
name: Kim, Ji-Yeon
name: Sim, Sung
name: Bhumsuk Keam
name: Kim, Tae
name: Kim, Dong-Wan
name: Heo, Dae
name: Se-Hoon Lee
name: Jong-Il Kim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary materials and methods. (DOC 21Â kb)
Additional file 4: Figure S3. of Assessment of global DNA methylation in the first trimester fetal tissues exposed to maternal cigarette smoking
Creators: name: Fa, Svetlana
name: Larsen, Trine
name: Bilde, Katrine
name: Daugaard, Tina
name: Ernst, Emil
name: Olesen, Rasmus
name: Mamsen, Linn
name: Ernst, Erik
name: Larsen, Agnete
name: Nielsen, Anders
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: DNA methylation in fetal small intestines. a DNA methylation in female and male fetal small intestines determined by the Elisa method using 5-mC-specific antibody (non-smoking female group N = 5, non-smoking male group N = 2, smoking female group N = 8, and smoking male group N = 4). Data represent the mean of two experiments. b Percentage of AluYb8 methylation at 5 consecutive CpG sites (non-smoking group N = 9 and smoking group N = 12). c AluYb8 DNA methylation in males and females (non-smoking female group N = 7, non-smoking male group N = 2, smoking female group N = 8, and smoking male group N = 4). d Percentage of LINE-1 DNA methylation at three consecutive CpG sites (non-smoking group N = 9 and smoking group N = 11). e LINE-1 DNA methylation in males and females (non-smoking female group N = 7, non-smoking male group N = 2, smoking female group N = 7, and smoking male group N = 4). Percentages of methylation were calculated and displayed as described in the legend for Fig. 1. Unpaired t test was used to compare non-smoking and smoking exposed group, while two-way ANOVA was used to compare combined effects of smoke exposure and gender. (PDF 529 kb)
Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G‐CSF regimen
Creators: name: Mohrez, Morad
name: Troeger, Anja
name: Kleinschmidt, Katharina
name: Hanafee Alali, Tarek
name: Jakob, Marcus
name: Brosig, Andreas Michael
name: Hähnel, Viola
name: Kietz, Silke
name: Offner, Robert
name: Burkhardt, Ralph
name: Corbacioglu, Selim
name: Ahrens, Norbert
name: Foell, Juergen
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: sickle cell trait, sickle cell disease, stem cell mobilization, stem cell transplantation, stem cell harvest
subject: 610 Medizin

description: Objectives
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA-matched sibling is currently the standard of care. Haploidentical HSCT from a family donor with a TCR αβ/CD19 depleted graft (T-haplo) is an increasingly successful alternative, which requires the generation of G-CSF stimulated peripheral stem cell (PBSC) from haploidentical relatives. These sickle cell trait (SCT) donors reported to develop SCD-related complications in conditions of severe stress.
Methods
In this retrospective analysis, we compared the safety and efficacy of PBSC mobilization with a G-CSF intensified mobilization regimen in SCT donors with a conventional G-CSF mobilization regimen in healthy donors.
Results
The reported adverse events were similar during intensified G-CSF mobilization, apheresis, and shortly after stem cell apheresis in SCT and control donors. In SCT and control donors, we were able to mobilize high yields of CD34+ stem cells and the harvested CD34+ cell count was comparable with control donors.
Conclusions
Peripheral stem cell mobilization using an intensified G-CSF regimen is safe, and well tolerated among SCT donors. SCT donors are a valid alternative for collection of peripheral CD34+ stem cells for T-cell-depleted haploidentical stem cell transplantation.
Additional file 1: of Polygenic sex determination in the cichlid fish Astatotilapia burtoni
Creators: name: Roberts, Natalie
name: Juntti, Scott
name: Coyle, Kaitlin
name: Dumont, Bethany
name: M. Stanley
name: Ryan, Allyson
name: Fernald, Russell
name: Reade Roberts
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Alignment of A. burtoni scaffolds to anchored O. niloticus (Nile tilapia) genome. (PDF 725 kb)
Epidemiology and treatment of proximal femoral fractures in the elderly U.S. population
Creators: name: Walter, Nike
name: Szymski, Dominik
name: Kurtz, Steven M.
name: Lowenberg, David W.
name: Alt, Volker
name: Lau, Edmund C.
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Proximal femoral fractures are a serious complication, especially for elderly patients. Detailed epidemiological analyzes provide a valuable resource for stakeholders in the health care system in order to foresee future development possibly influenceable by adaption of therapeutic procedures and prevention strategies. This work aimed at answering the following research questions: (1) What are the incidence rates of proximal femoral fractures in the elderly U.S. population? (2) What is the preferred treatment procedure for these fractures? Proximal femoral fractures occurred between January 1, 2009 and December 31, 2019 in patients ≥ 65 years were identified from the Medicare Physician Service Records Data Base. The 5% sample of Medicare beneficiaries, equivalent to the records from approximately 2.5 million enrollees formed the basis of this study. Fractures were grouped into head/neck, intertrochanteric, and subtrochanteric fractures. The overall incidence rate, age and sex specific incidence rates as well as incidence rate ratios were calculated. Common Procedural Terminology (CPT) codes were used to identify procedures and operations. In 2019, a total number of 7982 femoral head/neck fractures was recorded. In comparison to 9588 cases in 2009, the incidence substantially decreased by 26.6% from 666.7/100,000 inhabitants to 489.3/100,000 inhabitants (z =  − 5.197, p < 0.001). Also, in intertrochanteric fractures, a significant decline in the incidence by 17.3% was evident over the years from 367.7/100,000 inhabitants in 2009 to 304.0 cases per 100,000 inhabitants in 2019 (z =  − 2.454, p = 0.014). A similar picture was observable for subtrochanteric fractures, which decreased by 29.6% (51.0 cases per 100,000 to 35.9 cases per 100,000) over the time period (z =  − 1.612, p = 0.107). Head/neck fractures were mainly treated with an arthroplasty (n = 36,301, 40.0%). The majority of intertrochanteric fractures and subtrochanteric fractures received treatment with an intramedullary device (n = 34,630, 65.5% and n = 5870, 77.1%, respectively). The analysis indicated that the incidence of all types of proximal femoral neck fractures decreased for the population of elderly patients in the U.S. within the last decade. Treatment of head and neck fractures was mainly conducted through arthroplasty, while intertrochanteric and subtrochanteric fractures predominantly received an intramedullary nailing.
MOESM1 of Hunting as a management tool? Cougar-human conflict is positively related to trophy hunting
Creators: name: Teichman, Kristine
name: Cristescu, Bogdan
name: Darimont, Chris
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Hypotheses for frequency of cougar-human conflict.
Treatment of extracapsular fractures of the mandibular condylar process: A retrospective evaluation of 377 cases
Creators: name: Maurer, Michael
name: Klaes, Tabea
name: Meier, Johannes K.
name: Gottsauner, Josef Maximilian
name: Taxis, Jürgen
name: Schuderer, Johannes
name: Reichert, Torsten E.
name: Ettl, Tobias
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: facial nerve palsy, malocclusion, mandibular condylar fracture, parotid complications, retromandibular transparotid approach
subject: 610 Medizin

description: Background/Aim
Mandibular condylar fractures represent 25%–35% of all mandibular fractures. Despite profound research, there is still a controverse debate about treating these fractures conservatively or by open reduction and internal fixation (ORIF).
The aim of this study is to analyse the outcome after open and closed treatment of extracapsular mandibular condyle fractures regarding general characteristics, post-treatment malocclusion, facial nerve palsy (FNP), maximum mouth opening (MMO) and parotid complications.
Methods
A retrospective cohort of 377 fractures (350 open, 27 closed treatment) was reviewed by reference to clinical and radiological pre- and postoperative documentation. Follow-up period was 12 months. Pearsons' chi-square-test, correlations, Kruskal–Wallis test and t-test were carried out for statistical analysis.
Results
The dominant type of fracture was type II in Spiessl and Schroll classification (50.1%). In the open treated fractures, the most common approach was retromandibular transparotid (91.7%). Post-treatment malocclusion occurred in 18.0% and was significantly increased in bilateral fractures (p = .039), in luxation fractures (p = .016) and in patients with full dentition (p = .004). After open reduction and internal fixation (ORIF), temporary FNP was documented in 7.1% whereas a permanent paresis occurred in 1.7%. FNP was significantly associated with high fractures (p = .001), comminution (p = .028) and increased duration of surgery (p = .040). Parotid complications were significantly associated with revision surgery (p = .009). Post-treatment reduction of MMO mainly occurred in female patients (p < .001) as well as in patients with bilateral fractures (p < .001), high fractures (p = .030) and concomitant mandibular (p = .001) and midfacial fractures (p = .009).
Conclusion
Malocclusion seems to be the most frequent long-term complication after open reduction and osteosynthesis of extracapsular mandibular condyle fractures. We suggest ORIF by a transparotid approach to be an appropriate treatment with a low complication rate regarding especially FNP for extracapsular fractures of the mandibular condyle.
Additional file 1: of Interaction network of tobacco etch potyvirus NIa protein with the host proteome during infection
Creators: name: Martínez, Fernando
name: Rodrigo, Guillermo
name: Aragonés, Verónica
name: Ruiz, Marta
name: Lodewijk, Iris
name: Fernández, Unai
name: Elena, Santiago
name: José-Antonio Daròs
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: cDNA sequences of wild-type NIa (from nucleotide 5692 to 6981 of GenBank accession DQ986288) and the five tagged variants TSTNIa1 to 5. Twin-Strep-tag (TST) sequence is on yellow background; codons corresponding to amino acids binding Strep-Tactin and to spacers in blue and gray, respectively. Positions corresponding to the different NIaPro autoproteolytic sites are on blue background. Mutation C6037T that increases viral load and infectivity in A. thaliana Ler-0 is in red. In TSTNIa1 and TSTNIa3 the three codons in front of TST are duplicated (italics) after the tag, but include a silent mutation (in red) to avoid homologous repetitions. (PDF 66 kb)
Potamolepidae Brien 1967
Creators: name: Copeland, John
name: Pronzato, Roberto
name: Manconi, Renata
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Haplosclerida
Potamolepidae

description: FAMILY POTAMOLEPIDAE BRIEN, 1967
Synonymy. Potamolepidae Brien, 1967; Manconi and Pronzato, 2002; Potamophloiinae Brien, 1969 [Type genus Potamolepis Marshall, 1883]
Family definition (emended from Manconi & Pronzato, 2002, 2009). Spongillina with growth form from encrusting or massive to arborescent with irregular lobes, ridges or branches. Consistency from rigid to stony hard, fragile particularly at the sponge base that generally remains adherent to substrata during sampling. Spongin scanty except for the basal spongin plate and gemmular theca. Surface smooth to irregular with chimneys, to conulose with apices of ascending primary fibers supporting conules. Oscules with exhalant star-shaped canals in some cases. No special ectosomal skeleton except for spicular tufts supporting conules and tangential microscleres in the dermal membrane (only some genera). Choanosomal skeleton irregularly alveolate-reticulate with mono- to paucispicular tracts sometimes ascending towards the surface, skeletal network notably dense at the surface and more loose and irregular at the sponge base. Megascleres strongyles to oxeas from smooth to ornamented by variably dense granules/spines/tubercles. Microscleres, if present, slender oxeas. Gemmules, when present, single to grouped, sometimes free at the sponge base or more frequently sessile and strictly adhering to the substratum by the basal spongin plate. Gemmular theca mono-, bi- to tri-layered, usually of compact spongin, with more or less tangentially embedded gemmuloscleres. Pneumatic layer absent to scarcely developed of fibrous, not chambered spongin. Foramen not always evident. Gemmuloscleres strongyle-like, short to elongate, ovular to variably bent (C-like to button-like) variably ornamented to entirely smooth. A second category of gemmuloscleres as large, stout, spiny to smooth oxeas. Parenchymella larvae entirely ciliated, with spicules.
description: Published as part of Copeland, John, Pronzato, Roberto & Manconi, Renata, 2015, Discovery of living Potamolepidae (Porifera: Spongillina) from Nearctic freshwater with description of a new genus, pp. 37-48 in Zootaxa 3957 (1) on page 39, DOI: 10.11646/zootaxa.3957.1.2, http://zenodo.org/record/288551
Additional file 1: of A multidimensional education program at substance dependence treatment centers improves patient knowledge and hepatitis C care
Creators: name: Marinho, Rui
name: Antรณnio Costa
name: Teodomiro Pires
name: Raposo, Helena
name: Vasconcelos, Carlos
name: Polรณnia, Cristina
name: Borges, Joaquim
name: Soares, Mariana
name: Graรงa Vilar
name: Nogueira, Ana
Publisher: name: Figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: This file contains the English language version of the questionnaire used in the study. (PDF 51ย�kb)
The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT)
Creators: name: Simoes, Jorge Piano
name: Schoisswohl, Stefan
name: Schlee, Winfried
name: Basso, Laura
name: Bernal-Robledano, Alberto
name: Boecking, Benjamin
name: Cima, Rilana
name: Denys, Sam
name: Engelke, Milena
name: Escalera-Balsera, Alba
name: Gallego-Martinez, Alvaro
name: Gallus, Silvano
name: Kikidis, Dimitris
name: López-Escámez, Jose A.
name: Marcrum, Steven C.
name: Markatos, Nikolaos
name: Martin-Lagos, Juan
name: Martinez-Martinez, Marta
name: Mazurek, Birgit
name: Vassou, Evgenia
name: Jarach, Carlotta Micaela
name: Mueller-Locatelli, Nicolas
name: Neff, Patrick
name: Niemann, Uli
name: Omar, Hafez Kader
name: Puga, Clara
name: Schleicher, Miro
name: Unnikrishnan, Vishnu
name: Perez-Carpena, Patricia
name: Pryss, Rüdiger
name: Robles-Bolivar, Paula
name: Rosenauer, Matthias
name: Schecklmann, Martin
name: Schiele, Tabea
name: Schobel, Johannes
name: Spiliopoulou, Myra
name: Stark, Sabine
name: Vogel, Carsten
name: Wunder, Nina
name: Zachou, Zoi
name: Langguth, Berthold
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Background

Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potentially increased effectiveness of a combination of treatments and personalized treatments for each tinnitus patient.
Methods

Within the Unification of Treatments and Interventions for Tinnitus Patients project, a multicenter, randomized clinical trial is conducted with the aim to compare the effectiveness of single treatments and combined treatments on tinnitus distress (UNITI-RCT). Five different tinnitus centers across Europe aim to treat chronic tinnitus patients with either cognitive behavioral therapy, sound therapy, structured counseling, or hearing aids alone, or with a combination of two of these treatments, resulting in four treatment arms with single treatment and six treatment arms with combinational treatment. This statistical analysis plan describes the statistical methods to be deployed in the UNITI-RCT.
Discussion

The UNITI-RCT trial will provide important evidence about whether a combination of treatments is superior to a single treatment alone in the management of chronic tinnitus patients. This pre-specified statistical analysis plan details the methodology for the analysis of the UNITI trial results.
Trial registration

ClinicalTrials.gov NCT04663828. The trial is ongoing. Date of registration: December 11, 2020. All patients that finished their treatment before 19 December 2022 are included in the main RCT analysis.
MOESM4 of Hunting as a management tool? Cougar-human conflict is positively related to trophy hunting
Creators: name: Teichman, Kristine
name: Cristescu, Bogdan
name: Darimont, Chris
Publisher: name: Figshare
Year: 2016
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 4: Tables S2–S11. List of all cougar-human conflict models that received support (ΔAICc ≤ 7). Estimated coefficients from substantially supported (ΔAICc
Cherokeesia Copeland, Pronzato & Manconi, 2015, n. gen.
Creators: name: Copeland, John
name: Pronzato, Roberto
name: Manconi, Renata
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Spongillida
Potamolepidae
Cherokeesia

description: Genus Cherokeesia n. gen.
Diagnosis. Cherokeesia diverges from all the other known genera of the family Potamolepidae for diagnostic traits of the gemmules and skeleton. See species diagnosis.
Etymology. The genus name (feminine) is derived from the valiant and proud North American native people known as the Cherokee (possibly from the Choctaw Cha-la-kee meaning “people of the mountains” or Chi-luk-ikbi meaning “people of the cave country”).
description: Published as part of Copeland, John, Pronzato, Roberto & Manconi, Renata, 2015, Discovery of living Potamolepidae (Porifera: Spongillina) from Nearctic freshwater with description of a new genus, pp. 37-48 in Zootaxa 3957 (1) on page 39, DOI: 10.11646/zootaxa.3957.1.2, http://zenodo.org/record/288551
Additional file 2: of Gestational age, mode of birth and breastmilk feeding all influence acute early childhood gastroenteritis: a record-linkage cohort study
Creators: name: Bentley, Jason
name: Simpson, Judy
name: Bowen, Jenny
name: Morris, Jonathan
name: Roberts, Christine
name: Nassar, Natasha
Publisher: name: Figshare
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: â  All adjusted associations.pdfâ   summarises the adjusted associations for the study factors and all covariates used in the adjustment for the main and additional study populations. (DOC 84 kb)
Additional file 2: of Polygenic sex determination in the cichlid fish Astatotilapia burtoni
Creators: name: Roberts, Natalie
name: Juntti, Scott
name: Coyle, Kaitlin
name: Dumont, Bethany
name: M. Stanley
name: Ryan, Allyson
name: Fernald, Russell
name: Reade Roberts
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Alignment of A. burtoni scaffolds to anchored M. zebra genome. (PDF 619 kb)
La Sobre Contención Escolar: La Teoría De Equidad Laboral Dentro De Las Aulas
Creators: name: Di Muro Madrid, Cristian Fabián
Publisher: name: Zenodo
Year: 2024

description: This study introduces and analyzes the concept of sobre contención escolar (over-schooling containment), which hypothesizes that excessive flexibility in public education institutions' approval criteria negatively impacts classroom dynamics. Drawing on Adams' Equity Theory, the paper argues that such practices—ranging from leniency in attendance and behavior policies to additional remedial opportunities—may demotivate students due to perceived inequities. Data from surveys conducted in three public high schools in Mar del Plata reveal significant student discontent with institutional favoritism, citing a decline in their performance when perceiving inequitable grading and effort-reward ratios. The findings suggest that sobre contención escolar warrants further investigation and actionable interventions to mitigate its adverse effects on academic performance and group dynamics.
Additional file 3: Table S2. of Pedobarographic and kinematic analysis in the functional evaluation of two post-operative forefoot offloading shoes
Creators: name: Caravaggi, Paolo
name: Giangrande, Alessia
name: Berti, Lisa
name: Lullini, Giada
name: Leardini, Alberto
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Kinematic parameters in the contralateral limb.Range of motion and maximum/minimum sagittal-plane rotation angles [deg] at the hip, knee and ankle joint in the left side (where the control shoe was worn), for each of the three shoe conditions on the right side. Kinematic parameters were determined according to [18].Â (DOCX 14 kb)
Ex vivo expansion of lung cancer‐derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression
Creators: name: Treitschke, Steffi
name: Weidele, Kathrin
name: Varadarajan, Adithi Ravikumar
name: Feliciello, Giancarlo
name: Warfsmann, Jens
name: Vorbeck, Sybille
name: Polzer, Bernhard
name: Botteron, Catherine
name: Hoffmann, Martin
name: Dechand, Vadim
name: Mederer, Tobias
name: Weber, Florian
name: Werner‐Klein, Melanie
name: Robold, Tobias
name: Hofmann, Hans‐Stefan
name: Werno, Christian
name: Klein, Christoph A.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: disseminated cancer cells, lung cancer, metastatic precursor cells, sphere culture
subject: 610 Medizin

description: The cellular basis of the apparent aggressiveness in lung cancer is poorly understood but likely associated with functional or molecular features of disseminated cancer cells (DCCs). DCCs from epithelial cancers are mostly detected by antibodies directed against histogenetic markers such as cytokeratin or EpCAM. It has been argued that marker-negative metastatic founder cells might escape detection. We therefore used ex vivo sphere formation for functional detection of candidate metastasis founders. We generated cell suspensions from 199 LN samples of 131 lung cancer patients and placed them into non-adherent cell culture. Sphere formation was associated with detection of DCCs using EpCAM immunocytology and with significantly poorer prognosis. The prognostic impact of sphere formation was strongly associated with high numbers of EpCAM-positive DCCs and aberrant genotypes of expanded spheres. We also noted sphere formation in patients with no evidence of lymphatic spread, however such spheres showed infrequent expression of signature genes associated with spheres from EpCAM-positive samples and displayed neither typical lung cancer mutations (KRAS, TP53, ERBB1) nor copy number variations, but might be linked to disease progression >5 years post curative surgery. We conclude that EpCAM identifies relevant disease-driving DCCs, that such cells can be expanded for model generation and that further research is needed to clarify the functional and prognostic role of rare EpCAM-negative sphere forming cells.
Additional file 1: of The transcriptional profile of coronary arteritis in Kawasaki disease
Creators: name: Rowley, Anne
name: Wylie, Kristine
name: Kwang-Youn Kim
name: Pink, Adam
name: Yang, Amy
name: Reindel, Rebecca
name: Baker, Susan
name: Shulman, Stanford
name: Orenstein, Jan
name: Lingen, Mark
name: Weinstock, George
name: Wylie, Todd
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Supplemental Methods. Table S1. RNA sequencing metrics. Table S2. All differentially expressed genes (8 KD cases vs 7 controls). Table S3. Dysregulated molecular pathways (8 KD cases vs 7 controls). Table S4. Differential expression of genes involved in antigen presentation and dendritic cell function in KD compared to control coronary arteries by real-time reverse transcriptase PCR assays. Table S5. Extracellular genes dysregulated in 8 KD coronary arteries compared with 7 childhood control coronary arteries. Figure S1. Principal components analysis of all genes in 8 KD (4 treated and 4 untreated) and 7 childhood control coronary artery tissues demonstrates that gene expression of untreated (red dots) and treated (black dots) KD patients are not distinguishable. (PDF 382 kb)
La Percepción Y El Rendimiento Docente: La Teoría De Equidad Laboral Dentro De La Educación Pública
Creators: name: Di Muro Madrid, Cristian Fabián
Publisher: name: Zenodo
Year: 2024

description: This study explores the perception of inequity in the public education system, specifically focusing on teachers' views of institutional structures, peer performance, and school practices. It is hypothesized that such perceptions can contribute to feelings of workplace inequity, which may impact motivation and overall performance. Using a survey method, 28 teachers from public secondary schools in Mar del Plata, Buenos Aires, were asked to respond to questions related to the perceived effort and compensation disparities among colleagues, the role of institutional commitment, and the impact of educational practices such as grade flexibility and reward systems. Drawing on John Stacey Adams’ equity theory, the findings suggest that teachers feel a sense of inequity when they perceive discrepancies in work effort and outcomes, particularly in the context of remuneration and institutional support. The survey results highlight that many teachers believe the current reward systems, including the practice of purchasing unearned certifications, exacerbate this inequity. Additionally, the perception of stronger institutional commitment correlates with more effective teaching practices. The study concludes that a more equitable reward system, linked to teacher performance, could reduce these perceptions of inequity and improve overall morale and efficiency within the public education sector. Further research with a larger sample size may yield similar results, reinforcing the significance of addressing these issues in educational policy.
Additional file 3: of Gestational age, mode of birth and breastmilk feeding all influence acute early childhood gastroenteritis: a record-linkage cohort study
Creators: name: Bentley, Jason
name: Simpson, Judy
name: Bowen, Jenny
name: Morris, Jonathan
name: Roberts, Christine
name: Nassar, Natasha
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: â  Additional combined adjusted associations.pdfâ   summarises the combined associations for the study factors for all additionally investigated study populations. (DOC 443 kb)
Jubogaster Parker & Maruyama 2013
Creators: name: Parker, Joseph
name: Maruyama, Munetoshi
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Silphidae
Jubogaster

description: Molecular phylogenetic placement of Jubogaster
While the head of Jubogaster is suggestive of Trogastrini, other characters typical of this tribe are absent. There is no dense genal beard of setae, the tarsal claws are both well-developed and equally-sized, rather than being unequal in size or consisting of one well-developed and one setiferous claw. A strongly-impressed median longitudinal sulcus on the pronotal disc is also lacking; although the sulcus is present, it is barely evident and only weaklydefined. Furthermore, the obcordate form of the pronotum, sharply constricted at the base, is far more similar to members of Jubini, another euplectite tribe.
Jubogaster ’s curious suite of features confounds a definitive assignment of the new taxon to tribe using morphology alone. To reliably place Jubogaster phylogenetically, we employed a non-destructive procedure to extract DNA from the type specimen, without damaging or altering its external morphology (Gilbert et al. 2007). Using this approach, we successfully amplified a fragment of 28s rDNA from J. towai. This region is particularly informative for higher-level pselaphine systematics, resolving many relationships at the supertribal, tribal and subtribal levels (J. Parker and A. Vogler, unpublished data). We also sequenced this gene region from a range of other Pselaphinae including 5 genera of Trogastrini, 3 Jubini genera, and representatives of all other euplectite tribes except Metopiasini, Dimerini and Mayetiini. A variety of non-euplectite pselaphines from different supertribes were included, totalling 24 ingroup taxa. Three other staphylinids (from the subfamilies Proteininae, Euaesthetinae and Scydmaeninae) and the silphid Silpha obscura were used as outgroups.
Both MP (Fig 11) and Bayesian (Fig 12) analyses placed Jubogaster within the Trogastrini with maximum support, forming a clade with Platomesus and Rhexius. This placement was recovered across all alignment parameter combinations tested with consistently high support. Although the taxonomic coverage is limited, Jubogaster emerges in the same position in a far more comprehensive analysis of>150 ingroup taxa, with extensive taxon sampling from almost all pselaphine tribes and subtribes (data not shown; J. Parker and A. Vogler, unpublished data). Hence, we conclude with a high degree of certainty that Jubogaster is indeed a member of Trogastrini.
description: Published as part of Parker, Joseph & Maruyama, Munetoshi, 2013, Jubogaster towai, a new Neotropical genus and species of Trogastrini (Coleoptera: Staphylinidae: Pselaphinae) exhibiting myrmecophily and extreme body enlargement, pp. 369-378 in Zootaxa 3630 (2) on pages 375-376, DOI: 10.11646/zootaxa.3630.2.11, http://zenodo.org/record/222179