cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metabolic Engineering of Acinetobacter baylyiADP1 for Protein Production
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: B230 - Pharmacy

description: Vaccinations are a crucial preventative measure to stop the spread of a disease. However, due to the need to follow a cold chain procedure, the cost of transport for keeping the vaccine at +2 °C to +8 °C temperature at all times to avoid any loss of efficiency can become a hindrance in supplying vaccines. In an effort to be able to transport these essential vaccines, a new transport method is needed. By creating a new system for transport, it is hoped vaccines can be more readily available to everyone.This aim of this research was to develop a new production system to produce an additive for modifying the formulation of proteinaceous drugs to enable thermostability. This system would increase the thermostable range of vaccinations. The protein Mannosylglycerate, MG, from Rhodothermus marinus, has the potential to work in this type of system. By isolating the mgs gene which produces this compound, a genetically modified Acinetobacter bayliiADP1strain can be produced. Using this gene and the metabolic pathway of metZ in ADP1, a microbial factory capable of biosynthesising MG can be developed. The protein could then be purified and added to a vaccination mixture and make it more thermostable in hotter temperatures.Several different methods were used throughout the research, mainly bacterial cell culture and plasmid manipulation. Batch culture was used to observe the growth of a plasmid-containing bacterial cell culture at high and optimum temperatures, one with the mgs gene present and one without, to allow the thermostable properties of MG to be seen. This experiment produced inconclusive results as the organism containing the plasmid with the mgs gene did not grow as expected.Following this, a shuttle vector of PCR Blunt and metZ was constructed using restriction enzyme BglII and ligation methods. This construct was planned as a base in which further plasmid manipulation was to be performed to insert the mgs gene. However, when the kanamycin resistance cassette was ligated into this shuttle vector with BamHI and BglII restriction enzymes, a crossover event occurred, and the shuttle vector had to be changed to pUC19.A new plasmid construct of pUC19 and metZ was created using the restriction enzyme EcoRI and ligation methods, and blue/white screening was used to isolate the plasmids containing the correct insert after ligation. This new vector showed promise but due to time constraints the research was not completed. However, this did highlight the potential for using the metabolic pathway of metZ in Acinetobacter baylyi ADP1 to insert the mgs gene for the production of MG.
A Topographical Study of the Urban Features of Ghadames, Libya
Creators: name: Aiblu, Aymen Ali Salem
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 50
subject: Philosophy and religious studies

description: Due to its strategic location connecting North Africa to Cairo in Egypt, and Timbuktu in Mali, the old town of Ghadames has long been regarded as one of the most significant cultural and commercial centers of the Sahara Desert. Ghadames has several distinctive topographical characteristics, and its vernacular architecture is unique in terms of material use and urban morphology that has a sustainable living quality which provided the community with its own privacy and way of life. This thesis will examine the urban fabric of Ghadames by conducting a historical and analytical study that will focus on the Urban morphology. This study seeks to comprehend the circumstances that led to the organic formation of the town. It will also study the cultural identity of its inhabitants and the interaction patterns of its population.
Laboratory Evaluation of Nanoparticle Penetration Efficiency in a Cylindrical Counter Flow Denuder for Non-Specific Removal of Trace Gases
Creators: name: Hagino, Hiroyuki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 60506 Virology

description: This paper presents a cylindrical counter-current flow diffusion denuder with high efficiency penetration of nanoparticles, for non-specific removal of trace gases from an air flow. The denuder was designed to exchange gases in the sample flow by diffusion to the purge flow across a cylindrical microporous glass tube. Laboratory test results indicated that removal efficiencies of gases increased with a lower sample flow rate and a higher sample to purge flow rate ratio. Additionally, the pore size of the microporous glass did not affect gas removal efficiency and particle penetration following optimization of sample and purge flow rate conditions. Significantly high particle penetration was obtained for the counter flow denuder technique (94% penetration for 20 nm of polystyrene latex particle [PSL]) that agreed with theoretical estimation attributed to diffusion loss.
Levels, Sources, and Risk Assessment of Polychlorinated Biphenyls (PCBs) in Soils from Industrial Areas: A Case Study from Saudi Arabia
Creators: name: Al-Wabel, Mohammad I.
name: Usman, Adel R. A.
name: El-Saeid, Mohamed H.
name: Al-Turki, Ali M.
name: Hassanin, Ashraf S.
name: Aarif H. El-Mubarak
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The objective of this study was to assess the pollution levels, sources, and human health risk of polychlorinated biphenyls (PCBs) in soils of industrial areas of the central and eastern regions of Saudi Arabia. Therefore, the surface soil samples from industrial areas (cement kiln, oil refinery, electric power plant, steel industry, and desalination plant) were collected and analyzed by High-Resolution Gas Chromatography-Mass Spectrometry/Mass Spectrometry-Time of Flight (HRGC-MS/MS-TOF) to quantify the levels of 26 PCBs (including 12 dioxin-like PCBs and 14 indicator-PCBs). The investigated 26 PCBs were detected in all soil samples. The total PCBs concentration (from tri-CBs to hepta-CBs) ranged from 171 to 4892 pg g−1 with an average of 1369 pg g−1 in soils of the central region and of 142–1231 pg g−1 with an average of 302 in soils of the eastern region, showing higher values at cement factory and/or oil refinery sites. Overall, the indicator-PCBs were the main congeners and contributed dominantly to the total mass of PCBs in comparison with the dioxin-like PCB congeners, with the most abundant for PCB-180 in the soil samples of the central region. Among individual dioxin-like PCBs, PCB-126 had the highest average value of the toxicity equivalence (TEQ). The TEQ values of ∑12dioxin-like PCBs did not exceed the Canadian soil quality guidelines of dioxin (4 pg TEQ g−1). Based on human health risk assessment via ingestion, dermal contact, and inhalation, low adverse effects of PCBs could be expected as indicated by lower values of cancer risk (≤10−6). The principal component analysis indicated that there is a different source of PCBs with similar or different PCB profiles.
A reflective architecture to support dynamic software evolution
Creators: name: Rank, Stephen
Publisher: name: University of Lincoln
Year: 2024
Subjects: I100 - Computer science
I300 - Software engineering
I310 - Software design
I320 - Programming

description: This thesis presents work which is concerned with the run-timeevolution of component-based software systems. In particular, themain result of the research presented here is a framework which isused to model and control the architecture of a software system. Thisframework allows the run-time manipulation of the components whichmake up a software system. The framework makes the architecture ofsoftware systems visible, and allows interaction with it, using areflective meta-object protocol.The motivating objectives of this work are providing a framework tosupport architectural flexibility, higher-level intervention, safechanges, and architectural visibility in software systems.The framework's behaviour and structure was motivated by a set ofcase-studies which have been used to guide its development andenhancement. The framework was developed iteratively, using eachcase-study in turn to evaluate its capabilities and to prompt thedirection of development. A detailed set of evaluation criteria are developed, and the frameworkis evaluated with respect to these. The framework was found to meeteach of the four objectives fully, with the exception of the aim toallow only safe changes which is only partly satisfied. Ways in whichthe framework can be improved in order to more fully satisfy itsobjectives are suggested, as are other extensions to its behaviour.
A reflective architecture to support dynamic software evolution
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: I100 - Computer science
I300 - Software engineering
I310 - Software design
I320 - Programming

description: This thesis presents work which is concerned with the run-timeevolution of component-based software systems. In particular, themain result of the research presented here is a framework which isused to model and control the architecture of a software system. Thisframework allows the run-time manipulation of the components whichmake up a software system. The framework makes the architecture ofsoftware systems visible, and allows interaction with it, using areflective meta-object protocol.The motivating objectives of this work are providing a framework tosupport architectural flexibility, higher-level intervention, safechanges, and architectural visibility in software systems.The framework's behaviour and structure was motivated by a set ofcase-studies which have been used to guide its development andenhancement. The framework was developed iteratively, using eachcase-study in turn to evaluate its capabilities and to prompt thedirection of development. A detailed set of evaluation criteria are developed, and the frameworkis evaluated with respect to these. The framework was found to meeteach of the four objectives fully, with the exception of the aim toallow only safe changes which is only partly satisfied. Ways in whichthe framework can be improved in order to more fully satisfy itsobjectives are suggested, as are other extensions to its behaviour.
Student voice in building schools for the future
Creators: name: Mason, Wendy
Publisher: name: University of Lincoln
Year: 2024
Subjects: N224 - Management & organisation of education
X330 - Academic studies in secondary education

description: The research explores student voice in the process of designing schools, using a case study of a Buildings Schools for the Future (BSF) One School Pathfinder project, 2005 – 2007. The suggestions made by the students during the design development were compared with those raised by the staff and parents to discover if the student voice brought anything different or unique to the project. Comparisons were then made with the Student Council’s contribution on projects at two schools local to the case study school. To explore the contribution made by ‘non traditional students’ a similar exercise was conducted in a Pupil Referral Unit (PRU) with students who had been expelled from mainstream schools because of behavioural issues. Group interviews and focus group feedback from students at the case study school, from different stages of the design process were examined to assess the impact the student voice may have had on the completed design. Interviews were conducted with members of the design team at the case study school to establish how much impact the student voice was perceived to have had on the completed design compared with the voice of others, whether it brought innovation to the design and if involvement in the project had an impact on the students. Comparisons were then made with interviews held at a second BSF Pathfinder in a neighbouring Local Authority and the findings submitted for peer review.The findings appear to demonstrate that there is very little difference in what the student voice contributes; across schools and across time, the student voice is consistent and predictable. The impact of the student voice was found to be minimal compared with the impact of others. The process of involving students in the design process was however felt to benefit the students and the design process. Finally suggestions are made as to how the involvement of student voice can be improved, and moved from a consultation process to one of collaboration in the future; for ways to address the balance of power within the design team and for further areas of research.
Student voice in building schools for the future
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: N224 - Management & organisation of education
X330 - Academic studies in secondary education

description: The research explores student voice in the process of designing schools, using a case study of a Buildings Schools for the Future (BSF) One School Pathfinder project, 2005 – 2007. The suggestions made by the students during the design development were compared with those raised by the staff and parents to discover if the student voice brought anything different or unique to the project. Comparisons were then made with the Student Council’s contribution on projects at two schools local to the case study school. To explore the contribution made by ‘non traditional students’ a similar exercise was conducted in a Pupil Referral Unit (PRU) with students who had been expelled from mainstream schools because of behavioural issues. Group interviews and focus group feedback from students at the case study school, from different stages of the design process were examined to assess the impact the student voice may have had on the completed design. Interviews were conducted with members of the design team at the case study school to establish how much impact the student voice was perceived to have had on the completed design compared with the voice of others, whether it brought innovation to the design and if involvement in the project had an impact on the students. Comparisons were then made with interviews held at a second BSF Pathfinder in a neighbouring Local Authority and the findings submitted for peer review.The findings appear to demonstrate that there is very little difference in what the student voice contributes; across schools and across time, the student voice is consistent and predictable. The impact of the student voice was found to be minimal compared with the impact of others. The process of involving students in the design process was however felt to benefit the students and the design process. Finally suggestions are made as to how the involvement of student voice can be improved, and moved from a consultation process to one of collaboration in the future; for ways to address the balance of power within the design team and for further areas of research.
The challenges facing leaders and managers in the independent special school sector: a changing agenda
Creators: name: Roberts, Lesley
Publisher: name: University of Lincoln
Year: 2024
Subjects: X320 - Academic studies in primary education
X330 - Academic studies in secondary education
X360 - Academic studies in specialist education

description: This study investigates the challenges facing leaders and managers of independent special schools during the period during when inclusion of SEN students in mainstream schools has been government policy. The challenges investigated centre around ascertaining the key role of these schools at this time, the general challenges they have faced, and the implications for them in the years ahead. This has included research on how independent special schools respond to external demands and expectations and how they balance these with their own internal imperatives. The research was carried out using an empirical phenomenological approach, with the objective of gathering qualitative data through the undertaking of interviews at both the micro and meso level of the organisational structures involved in SEN education. Participants were drawn from three approved independent special schools and three non-maintained special schools from the south east regions of England. Schools represented varying medical forms of SEN such as deafness, physical disabilities, severe learning difficulties and specific learning difficulties. Interviewees consisted of the headteacher, a deputy and classroom teacher from each school and the data was triangulated through documentation analysis using the participating schools’ recent OFSTED and CSCI reports as well as interviews with three SEN Caseworkers employed by three different LEA regions. The findings revealed that a key role for independent special schools is propping up a seemingly failing national strategy. Challenges arise from educational matters when internal visions of what good special education should mean are over-ridden by external ideologies. External accountability tends to suppress innovation and change within the school by making the change process unwieldy. External accountabilities are inclined to conflict when they encroach upon the professionalism of staff, yet complement internal interests by effecting motivation to question objectives more closely. Balancing internal/external accountabilities is no problem for these leaders and managers, because their internal imperatives will always come first. Implications for the years ahead will arise from the success or failure of the national inclusion strategy to accommodate a rising number of SEN students under limited state provision.
The challenges facing leaders and managers in the independent special school sector: a changing agenda
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X320 - Academic studies in primary education
X330 - Academic studies in secondary education
X360 - Academic studies in specialist education

description: This study investigates the challenges facing leaders and managers of independent special schools during the period during when inclusion of SEN students in mainstream schools has been government policy. The challenges investigated centre around ascertaining the key role of these schools at this time, the general challenges they have faced, and the implications for them in the years ahead. This has included research on how independent special schools respond to external demands and expectations and how they balance these with their own internal imperatives. The research was carried out using an empirical phenomenological approach, with the objective of gathering qualitative data through the undertaking of interviews at both the micro and meso level of the organisational structures involved in SEN education. Participants were drawn from three approved independent special schools and three non-maintained special schools from the south east regions of England. Schools represented varying medical forms of SEN such as deafness, physical disabilities, severe learning difficulties and specific learning difficulties. Interviewees consisted of the headteacher, a deputy and classroom teacher from each school and the data was triangulated through documentation analysis using the participating schools’ recent OFSTED and CSCI reports as well as interviews with three SEN Caseworkers employed by three different LEA regions. The findings revealed that a key role for independent special schools is propping up a seemingly failing national strategy. Challenges arise from educational matters when internal visions of what good special education should mean are over-ridden by external ideologies. External accountability tends to suppress innovation and change within the school by making the change process unwieldy. External accountabilities are inclined to conflict when they encroach upon the professionalism of staff, yet complement internal interests by effecting motivation to question objectives more closely. Balancing internal/external accountabilities is no problem for these leaders and managers, because their internal imperatives will always come first. Implications for the years ahead will arise from the success or failure of the national inclusion strategy to accommodate a rising number of SEN students under limited state provision.
Researching mundane workplace activities: micro-analysis, ethnography and everyday work on the occasional working paper series at the University of lincoln
Creators: name: Dyer, Pete
Publisher: name: University of Lincoln
Year: 2024
Subjects: L370 - Social theory
L391 - Sociology of science & technology
N200 - Management studies
N215 - Organisational development

description: This dissertation will use Burrell and Morgan’s SociologicalParadigms and Organisational Analysis (1979) to make clear the centrality of theory-method in research practice. The researcher will locate his position within the ‘Radical Humanist’ paradigm. The research method will deploy an ethnographic approach to the field. The field of study is the University of Lincoln’s Occasional Working Paper Series, (OWPS) a student-led, peer reviewed online journal.OWPS is part of a wider initiative that seeks to encourageundergraduate publishing as well as student-lecturer collaborations.The informing theory is Social Construction of Technology (SCOT). Specifically, one of the main tenets of SCOT is ‘co-construction’ and this will be discussed. The study will assess whether ‘coconstruction’is taking place between ‘relevant user groups’, for instance, authors and reviewers. The aim of co-construction is to achieve stability of the technological artefact, in this example; it is the Online Journal System (OJS). There will also be a discussion about the appropriateness of ethnography in studying SCOT. Also, the researcher has some concerns about doing research. In particular, does theory-method remain consistent during immersion in field practice? Indeed, the researchers concerns are realised whilst producing field vignettes reveal contractions in his assumptions and ethnographic writing. This is also discussed. The study will focus on the mundanity of everyday work and theinfluence of technology within OWPS. Also, the study will question whether the issue of involvement is tangible or mere rhetoric. There are of course some suggestions for how this dissertation might be extended for future research.
MOESM2 of Motif signatures in stretch enhancers are enriched for disease-associated genetic variants
Creators: name: Quang, Daniel
name: Erdos, Michael
name: Parker, Stephen
name: Collins, Francis
Publisher: name: figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Supplementary Figures S1 to S13.
Researching mundane workplace activities: micro-analysis, ethnography and everyday work on the occasional working paper series at the University of lincoln
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: L370 - Social theory
L391 - Sociology of science & technology
N200 - Management studies
N215 - Organisational development

description: This dissertation will use Burrell and Morgan’s SociologicalParadigms and Organisational Analysis (1979) to make clear the centrality of theory-method in research practice. The researcher will locate his position within the ‘Radical Humanist’ paradigm. The research method will deploy an ethnographic approach to the field. The field of study is the University of Lincoln’s Occasional Working Paper Series, (OWPS) a student-led, peer reviewed online journal.OWPS is part of a wider initiative that seeks to encourageundergraduate publishing as well as student-lecturer collaborations.The informing theory is Social Construction of Technology (SCOT). Specifically, one of the main tenets of SCOT is ‘co-construction’ and this will be discussed. The study will assess whether ‘coconstruction’is taking place between ‘relevant user groups’, for instance, authors and reviewers. The aim of co-construction is to achieve stability of the technological artefact, in this example; it is the Online Journal System (OJS). There will also be a discussion about the appropriateness of ethnography in studying SCOT. Also, the researcher has some concerns about doing research. In particular, does theory-method remain consistent during immersion in field practice? Indeed, the researchers concerns are realised whilst producing field vignettes reveal contractions in his assumptions and ethnographic writing. This is also discussed. The study will focus on the mundanity of everyday work and theinfluence of technology within OWPS. Also, the study will question whether the issue of involvement is tangible or mere rhetoric. There are of course some suggestions for how this dissertation might be extended for future research.
Developing a green leader model for primary schools
Creators: name: Dixon, David
Publisher: name: University of Lincoln
Year: 2024
Subjects: L433 - Education policy
N224 - Management & organisation of education
X320 - Academic studies in primary education

description: This research developed the first ‘Green’ model for primary school leadership, which aimed to address some of the actual and anticipated environmental problems through the way schools operate in the context of Curriculum, Campus and Community. It emerged through an empirical investigative study of eight English primary school Head Teachers who are pioneering environmental sustainability. A Post-modern perspective influenced the research methodology and helped to take a fresh and sceptical look at the leadership aims of primary schools in relation to the education system and general society. This involved a critical examination of the National College of School Leadership’s ‘Leadership for Sustainability’ and literature from the ‘Green Movement’. The findings suggested that leaders are needed with a certain kind of ‘Green’ values, knowledge and skills. Questions arose about how a type of ‘Distributed Leadership’ might lie within the new model and whether the model is feasible, given that the pursuance of its main objectives are not currently the priority of most schools. The thesis pointed to the need for a radical revision of what it means to be a primary school leader, in order to assist with the imperatives of a green sustainable economy which promises a better quality of life for more people. This is a ‘Big Claim’ for a small-scale study. It is hoped, therefore, that this modest thesis could be a catalyst for more wide-ranging research and thinking in this most vital area, in terms of education leadership’s role in securing the viability of modern civilisation.
Developing a green leader model for primary schools
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: L433 - Education policy
N224 - Management & organisation of education
X320 - Academic studies in primary education

description: This research developed the first ‘Green’ model for primary school leadership, which aimed to address some of the actual and anticipated environmental problems through the way schools operate in the context of Curriculum, Campus and Community. It emerged through an empirical investigative study of eight English primary school Head Teachers who are pioneering environmental sustainability. A Post-modern perspective influenced the research methodology and helped to take a fresh and sceptical look at the leadership aims of primary schools in relation to the education system and general society. This involved a critical examination of the National College of School Leadership’s ‘Leadership for Sustainability’ and literature from the ‘Green Movement’. The findings suggested that leaders are needed with a certain kind of ‘Green’ values, knowledge and skills. Questions arose about how a type of ‘Distributed Leadership’ might lie within the new model and whether the model is feasible, given that the pursuance of its main objectives are not currently the priority of most schools. The thesis pointed to the need for a radical revision of what it means to be a primary school leader, in order to assist with the imperatives of a green sustainable economy which promises a better quality of life for more people. This is a ‘Big Claim’ for a small-scale study. It is hoped, therefore, that this modest thesis could be a catalyst for more wide-ranging research and thinking in this most vital area, in terms of education leadership’s role in securing the viability of modern civilisation.
Conversatorios sobre Ciencia Abierta: reflexiones colectivas en comunidad
Creators: name: Xhardez, Verónica
name: Ación, Laura
name: Miguez, Paz
name: Ascenzi, Laura
Publisher: name: Zenodo
Year: 2024
Subjects: Ciencia Abierta
Open Science

description: En marzo de 2024 preparamos un ciclo de conversatorios sobre Ciencia Abierta en el que reflexionamos sobre distintos temas vinculados a la Ciencia Abierta para intentar comprender colectivamente cómo la aprendemos, cómo la aplicamos y qué implicaciones tiene para nuestra región. También para reconocer aquellas dimensiones de la Ciencia Abierta que incomodan desde la perspectiva latinoamericana  y reflexionar sobre ellas. En suma, buscamos reconocer sus ventajas y su potencia a través de debatir sobre su alcance y posibilidades.

En esta publicación, reflexionamos sobre estos aspectos.
Peer assisted learning in the acquisition of musical composition skills
Creators: name: Mugglestone, Hilda
Publisher: name: University of Lincoln
Year: 2024
Subjects: W390 - Music not elsewhere classified
X390 - Academic studies in education not elsewhere classified

description: The purpose of the study was to discover the effects of using peer assisted learning in acquiring skills in music composition. The ten criteria used for assessing the effects of peer assisted learning comprised six concerning social qualities and four relating to cognitive aspects of what might be learned from working and learning together. The research used both qualitative and quantitative methods, encompassing interviews with the teacher, questionnaires for the students and observation. The latter included a quantitative element. The research took place in the natural settings of timetabled music lessons in Year Seven at an English comprehensive secondary school. This peer assisted learning research is believed to be the only such project conducted entirely in the unadulterated classroom settings. The lessons followed the teacher’s choice of lesson material and the length of time normally allowed for lessons in that school. No changes in classroom organisation, timing, or for any other reason were requested by, or made for, the researcher. Each class was divided into groups whose size, ability and gender were determined by the teacher. From these groups, the teacher selected the three which were the focus of this research.All three of the sample groups showed some evidence of the beneficial effects of peer assisted learning socially and cognitively although this varied according to the children’s different ability levels. Peer assisted learning was found to be most successful where children were able to work together cohesively and communicate well, either verbally or musically. Most children either acquired new musical skills or enhanced those they already possessed through the use of peer assisted learning.
Expected developments of thermal networks in Switzerland to reduce CO2 emissions
Creators: name: Sommer, Tobias
Publisher: name: Zenodo
Year: 2022
Subjects: Thermal networks
District heating
Energieperspektiven 2050+

description: For the DeCarbCH Lunch-Talk on 30 November 2021, I estimated the role of thermal networks to decarbonize Switzerland. In this note I show the underlying data from currently available reports (Sres et al. 2014; Chambers et al. 2019; BAFU 2021; BFE 2021a; IRENA 2017; VFS 2021; TEP 2020; BFE 2020). Regarding the future development, (Chambers et al. 2019; Sres et al. 2014) indicate the potential of thermal networks based on technical feasibility and (TEP 2020; BFE 2020) show realistic pathways based on current trends, which are more conservative than the technical feasible potential.
description: + ID der Publikation: hslu_89274 + Art des Beitrages: Working Paper + Sprache: Deutsch + Letzte Aktualisierung: 2022-04-12 15:47:08
Geologie, Hydrologie und Landschaft des Murrhardter Waldes
Creators: name: Eisenhut, Eugen
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Peer assisted learning in the acquisition of musical composition skills
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: W390 - Music not elsewhere classified
X390 - Academic studies in education not elsewhere classified

description: The purpose of the study was to discover the effects of using peer assisted learning in acquiring skills in music composition. The ten criteria used for assessing the effects of peer assisted learning comprised six concerning social qualities and four relating to cognitive aspects of what might be learned from working and learning together. The research used both qualitative and quantitative methods, encompassing interviews with the teacher, questionnaires for the students and observation. The latter included a quantitative element. The research took place in the natural settings of timetabled music lessons in Year Seven at an English comprehensive secondary school. This peer assisted learning research is believed to be the only such project conducted entirely in the unadulterated classroom settings. The lessons followed the teacher’s choice of lesson material and the length of time normally allowed for lessons in that school. No changes in classroom organisation, timing, or for any other reason were requested by, or made for, the researcher. Each class was divided into groups whose size, ability and gender were determined by the teacher. From these groups, the teacher selected the three which were the focus of this research.All three of the sample groups showed some evidence of the beneficial effects of peer assisted learning socially and cognitively although this varied according to the children’s different ability levels. Peer assisted learning was found to be most successful where children were able to work together cohesively and communicate well, either verbally or musically. Most children either acquired new musical skills or enhanced those they already possessed through the use of peer assisted learning.
Sufficiency Revisited: Rethinking Statistical Algorithms in the Big Data Era
Creators: name: Lee, Jarod Y. L.
name: Brown, James J.
name: Ryan, Louise M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: The big data era demands new statistical analysis paradigms, since traditional methods often break down when datasets are too large to fit on a single desktop computer. Divide and Recombine (D&R) is becoming a popular approach for big data analysis, where results are combined over subanalyses performed in separate data subsets. In this article, we consider situations where unit record data cannot be made available by data custodians due to privacy concerns, and explore the concept of statistical sufficiency and summary statistics for model fitting. The resulting approach represents a type of D&R strategy, which we refer to as summary statistics D&R; as opposed to the standard approach, which we refer to as horizontal D&R. We demonstrate the concept via an extended Gamma–Poisson model, where summary statistics are extracted from different databases and incorporated directly into the fitting algorithm without having to combine unit record data. By exploiting the natural hierarchy of data, our approach has major benefits in terms of privacy protection. Incorporating the proposed modelling framework into data extraction tools such as TableBuilder by the Australian Bureau of Statistics allows for potential analysis at a finer geographical level, which we illustrate with a multilevel analysis of the Australian unemployment data. Supplementary materials for this article are available online.
Sufficiency Revisited: Rethinking Statistical Algorithms in the Big Data Era
Creators: name: Lee, Jarod Y. L.
name: Brown, James J.
name: Ryan, Louise M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: The big data era demands new statistical analysis paradigms, since traditional methods often break down when datasets are too large to fit on a single desktop computer. Divide and Recombine (D&R) is becoming a popular approach for big data analysis, where results are combined over sub-analyses performed in separate data subsets. In this paper, we consider situations where unit record data cannot be made available by data custodians due to privacy concerns, and explore the concept of statistical sufficiency for model fitting. The resulting approach represents a type of D&R strategy, which we refer to as summary statistics D&R. This is opposed to the standard approach, which we refer to as horizontal D&R. We demonstrate the concept via an extended Gamma-Poisson model, where summary statistics are extracted from different databases and incorporated directly into the fitting algorithm without having to combine unit record data. By exploiting the natural hierarchy of data, the proposed model has major benefits in terms of privacy protection. Incorporating the model into data extraction tools such as TableBuilder by the Australian Bureau of Statistics allows for potential analysis at a finer geographical level, which we illustrate with a multilevel analysis of Australian unemployment data. Supplementary materials for this article are available online.
Correcting Estimation Bias in Randomized Clinical Trials with a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided.
Correcting Estimation Bias in Randomized Clinical Trials With a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided. Supplementary materials for this article are available online.
Correcting Estimation Bias in Randomized Clinical Trials with a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided.
Artefacts in semivolatile organic compound sampling with polyurethane foam substrates in high volume cascade impactors
Creators: name: Galarneau, Elisabeth
name: Patel, Megha
name: Brook, Jeffrey R.
name: Charland, Jean-Pierre
name: Glasius, Marianne
name: Bossi, Rossana
name: Hung, Hayley
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Polyurethane foam (PUF) is known to sorb gas-phase semivolatile organic compounds (SVOCs) from ambient air and is used routinely in conventional high volume filter-sorbent sampling of such pollutants. PUF rings have also been employed as impaction substrates in a high volume cascade impactor (HVCI) used as a sampler for the evaluation of particle toxicity. Though nonvolatile particles (e.g., trace metals, inorganic ions) have been the primary focus, the sampler has also been used to measure particulate SVOC concentrations in ambient air. The aim of this work is to investigate the validity of the latter approach. The results of three sets of experiments conducted in Canada and Denmark are reported herein. Model compounds included native and deuterated polycyclic aromatic hydrocarbons (PAHs). The experiments demonstrated that HVCI PUF substrates sorb gas-phase PAH compounds and that the sorbed mass is subject to mobilization through and out of the sampler. Particulate concentrations of low molecular weight and volatile PAHs are therefore prone to overestimation in samples that have been analyzed after extraction of whole PUF substrates. Sonication of collected particles in water before solvent extraction is effective at dislodging them from the PUF but also acts to redistribute their originally particulate PAH mass back to the PUF and to the sonication water. As a result, the PAH content of particles measured after sonication and subsequent filtration does not accurately represent their true values. These artefacts affect not only measured PAH concentrations but also the results of toxicological assays that are conducted to test the characteristics of particles collected using HVCI PUF samplers.