cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biophysical Probes Reveal a “Compromise” Nature of the Methyl-lysine Binding Pocket in L3MBTL1
Creators: name: Herold, J. Martin
name: Kireev, Dmitri
name: Wigle, Tim
name: Gao, Cen
name: Norris, Jacqueline L.
name: Frye, Stephen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Histone lysine methylation (Kme) encodes essential information modulating many biological processes including gene expression and transcriptional regulation. However, the atomic-level recognition mechanisms of methylated histones by their respective adaptor proteins are still elusive. For instance, it is unclear how L3MBTL1, a methyl-lysine histone code reader, recognizes equally well both mono- and di-methyl marks, but ignores unmodified and trimethylated lysine residues. We made use of Molecular Dynamics (MD) and Free Energy Perturbation (FEP) techniques in order to investigate the energetics and dynamics of the methyllysine recognition. Isothermal Titration Calorimetry (ITC) was employed to experimentally validate the computational findings. Both computational and experimental methods were applied to a set of designed “biophysical” probes that mimic the shape of a single lysine residue and reproduce the binding affinities of cognate histone peptides. Our results suggest that, besides forming favorable interactions, the L3MBTL1 binding pocket energetically penalizes both methylation states and has most probably evolved as a “compromise” that non-optimally fit to both mono- and di-methyl-lysine marks.
Computational Design of the Sequence and Structure of a Protein-Binding Peptide
Creators: name: Purbeck, Carrie
name: Sammond, Deanne W.
name: Kuhlman, Brian
name: Siderovski, David P.
name: Butterfoss, Glenn L.
name: Bosch, Dustin E.
name: Machius, Mischa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The de novo design of protein-binding peptides is challenging, because it requires identifying both a sequence and a backbone conformation favorable for binding. We used a computational strategy that iterates between structure and sequence optimization to redesign the C-terminal portion of the RGS14 GoLoco motif peptide so that it adopts a new conformation when bound to Gαi1. An X-ray crystal structure of the redesigned complex closely matches the computational model, with a backbone RMSD of 1.1 Å.
Search Tools and Scholarly Citation Practices in Literary Studies
Creators: name: Lehnen, Carl
name: Insua, Glenda
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Purpose: The wide adoption of web-scale discovery tools calls into question the usefulness and viability of traditional subject indexes. This study examines this question of usefulness in the context of the discipline of literary studies. To what extent can researchers rely on the primary database devoted to language and literature study to discover relevant scholarship, and how does its performance compare to other common search tools? Design/methodology/approach: It uses a random sample of citations from articles published in the flagship journal, PMLA, to see how well the sources cited by literature scholars are covered in various search tools, including the MLA International Bibliography. Findings: Of the search tools investigated, Google Scholar found the largest number of citations, even when limiting to literary scholarship. However, the eclecticism of citations suggests that scholars benefit from using a variety of search tools and methods. Originality/Value: Although other studies have looked at discoverability in certain subject areas, this one focuses on literary studies. An understanding of the relative coverage of different search tools can inform librarian practices and recommendations.
Periodismo y riesgo en México. Agresiones contra periodistas y conformación de redes de acción social.
Creators: name: De Leon, Salvador
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 441008
subject: Sociology of culture
classificationCode: 470101
subject: Communication studies
classificationCode: 470105
subject: Journalism studies
classificationCode: 470107
subject: Media studies

description: Los periodistas son una comunidad profesional vulnerable a la violencia en nuestro país. La falta de garantías, tanto físicas como jurídicas, ocasiona que sean objeto de de agresiones cuyo motivo principal es la censura. Los ataques sufridos por los periodistas van desde las amenazas hasta el homicidio. Los agresores son diversos: el Estado a través de sus agentes, la delincuencia, los partidos políticos, sujetos particulares, entre otros. De acuerdo con la organización internacional Artículo 19 (2013), del 2009 al 2012 hubo 772 ataques contra informadores, entre ellos 35 asesinatos, y las estadísticas ofrecidas por diversos diagnósticos confirman el aumento constante de la violencia en contra de los periodistas a partir del año 2000. Esta violencia tiene una geografía que se distribuye en los estados del norte del país, el Golfo de México y el sur. Nuestro estudio indaga sobre el significado de la violencia para los periodistas y su articulación en las acciones que desarrollan diferentes redes de colectivos que han surgido con la motivación de enfrentarla, de cara a la estructura sociopolítica que parece favorecer su vulnerabilidad antes que su protección. El enfoque de análisis sociocultural se plantea aquí como el estudio de sujetos, los periodistas, que actúan dentro de sistemas complejos; la interacción entre agencia y estructura. La aproximación es interpretativa, con una estrategia metodológica cualitativa. La discusión final apunta a las condiciones de la transición democrática en México, concepto que enfatiza la fragilidad de los procesos políticos y las instituciones que, a pesar de ciertos avances procedimentales, no permiten que la democracia sustantiva se instale plenamente, y que en este caso se refiere a condiciones en las que los derechos a la expresión y a la información quedan disminuidos por las agresiones y su falta de castigo.
An Improved Analysis of Semidefinite Approximation Bound for Nonconvex Nonhomogeneous Quadratic Optimization with Ellipsoid Constraints
Creators: name: Xia, Yong
name: Wang, Shu
name: Xu, Zi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90C20, 90C22, 90C26

description: We consider the problem of approximating nonconvex quadratic optimization with ellipsoid constraints (ECQP). We show some SDP-based approximation bounds for special cases of (ECQP) can be improved by trivially applying the extened Pataki's procedure. The main result of this paper is to give a new analysis on approximating (ECQP) by the SDP relaxation, which greatly improves Tseng's result [SIAM Journal Optimization, 14, 268-283, 2003]. As an application, we strictly improve the approximation ratio for the assignment-polytope constrained quadratic program.
description: 12 pages
Construction of a Photoactivatable Profluorescent Enzyme Via Propinquity Labeling
Creators: name: Xu, Weichen
name: Lee, Hsien-Ming
name: Lawrence, David S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A strategy for the construction of a profluorescent caged enzyme is described. An active site-directed peptide-based affinity label was designed, synthesized, and employed to covalently label a non-active site residue in the cAMP-dependent protein kinase. The modified kinase displays minimal catalytic activity and low fluorescence. Photolysis results in partial cleavage of the enzyme-bound affinity label, restoration of enzymatic activity (60 – 80%) and a strong fluorescent response (10 – 20 fold). The caged kinase displays analogous behavior in living cells, inducing a light-dependent loss of stress fibers that is characteristic of cAMP action. This strategy furnishes molecularly engineered enzymes that can be remotely controlled in time, space, and total activity.
Multiple charge beam dynamics in Alternate Phase Focusing structure
Creators: name: Dechoudhury, S.
name: Chakrabarti, Alok
name: Chao, Y -C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Asymmetrical Alternate Phase (A-APF) focusing realized in a sequence of 36 Superconducting Quarter Wave Resonators has been shown to accelerate almost 81 % of input Uranium beam before foil stripper to an energy of 6.2 MeV/u from 1.3 MeV/u. Ten charge states from 34+ to 43+ could be simultaneously accelerated with the phase of resonators tuned for 34+. A-APF structure showed unique nature of large potential bucket for charge states higher than that of tuned one. Steering inherent to QWRs can be mitigated by selecting appropriate phase variation of the APF periods and optimization of solenoid field strengths placed in each of the periods. This mitigation facilitates multiple charge state acceleration scheme
description: 10 pages, 8 figures
Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions
Creators: name: Setola, Vincent
name: Roth, Bryan L.
name: Whitby, Landon R.
name: Vogt, Peter K.
name: Ando, Yoshio
name: Boger, Dale L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The design and synthesis of a β-turn mimetic library as a key component of a small molecule library targeting the major recognition motifs involved in protein–protein interactions is described. Analysis of a geometric characterization of 10,245 β-turns in the protein data bank (PDB) suggested that trans-pyrrolidine-3,4-dicarboxamide could serve as an effective and synthetically accessible library template. This was confirmed by initially screening select compounds against a series of peptide-activated GPCRs that recognize a β-turn structure in their endogenous ligands. This validation study was highlighted by identification of both nonbasic and basic small molecules with high affinities (Ki = 390 nM and 23 nM, respectively) for the κ-opioid receptor (KOR). Consistent with the screening capabilities of collaborators and following the design validation, the complete library was assembled as 210 mixtures of 20 compounds, providing a total of 4,200 compounds designed to mimic all possible permutations of 3 of the 4 residues in a naturally occurring β-turn. Unique to the design and because of the C2 symmetry of the template, a typical 20 × 20 × 20-mix (8,000 compounds prepared as 400 mixtures of 20 compounds) needed to represent 20 variations in the side chains of three amino acid residues reduces to a 210 × 20-mix, thereby simplifying the library synthesis and subsequent screening. The library was prepared using a solution-phase synthetic protocol with liquid–liquid or liquid–solid extractions for purification and conducted on a scale that insures its long-term availability for screening campaigns. Screening the library against the human opioid receptors (KOR, MOR, and DOR) identified not only the activity of library members expected to mimic the opioid receptor peptide ligands, but also additional side chain combinations that provided enhanced receptor binding selectivities (>100-fold) and affinities (as low as Ki = 80 nM for KOR). A key insight to emerge from the studies is that the phenol of Tyr in endogenous ligands bearing the H-Tyr-Pro-Trp/Phe-Phe-NH2 β-turn is important for MOR binding, but may not be important for KOR (accommodated, but not preferred) and that the resulting selectivity for KOR observed with its removal can be increased by replacing the phenol OH with a chlorine substituent further enhancing KOR affinity.
Femtomole SHAPE Reveals Regulatory Structures in the Authentic XMRV RNA Genome
Creators: name: Gorelick, Robert J.
name: Grohman, Jacob K.
name: Allbritton, Nancy L.
name: Weeks, Kevin M.
name: Kottegoda, Sumith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Higher-order structure influences critical functions in nearly all non-coding and coding RNAs. Most single-nucleotide resolution RNA structure determination technologies cannot be used to analyze RNA from scarce biological samples, like viral genomes. To make quantitative RNA structure analysis applicable to a much wider array of RNA structure-function problems, we developed and applied high-sensitivity selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) to structural analysis of authentic genomic RNA of the xenotropic murine leukemia virus-related virus (XMRV). For analysis of fluorescently labeled cDNAs generated in high-sensitivity SHAPE experiments, we developed a two-color capillary electrophoresis approach with zeptomole molecular detection limits and sub-femtomole sensitivity for complete SHAPE experiments involving hundreds of individual RNA structure measurements. High-sensitivity SHAPE data correlated closely (R = 0.89) with data obtained by conventional capillary electrophoresis. Using high-sensitivity SHAPE, we determined the dimeric structure of the XMRV packaging domain, examined dynamic interactions between a packaging domain RNA and viral nucleocapsid protein inside virion particles, and identified the packaging signal for this virus. Despite extensive sequence differences between XMRV and the intensively studied Moloney murine leukemia virus, architectures of the regulatory domains are similar and reveal common principles of gammaretrovirus RNA genome packaging.
Supplementary document for Holographic Reconstruction Enhancement via Unpaired Image-to-Image Translation - 6118064.pdf
Creators: name: Scherrer, Romane
name: Quiniou, Thomas
name: Jauffrais, Thierry
name: Lemonnier, Hugues
name: Bonnet, Sophie
name: Selmaoui-Folcher, Nazha
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplement 1
Natural liquid organic hydrogen carrier with low dehydrogenation energy: A first principles study
Creators: name: Tang, Chunguang
name: Fei, Shunxin
name: Lin, G. David
name: Liu, Yun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Liquid organic hydrogen carriers (LOHCs) represent a promising approach for hydrogen storage due to their favorable properties including stability and compatibility with the existing infrastructure. However, fossil-based LOHC molecules are not green or sustainable. Here we examined the possibility of using norbelladine and trisphaeridine, two typical structures of Amaryllidaceae alkaloids, as the LOHCs from the sustainable and renewable sources of natural products. Our first principles thermodynamics calculations reveal low reversibility for the reaction of norbelladine to/from perhydro-norbelladine because of the existence of stabler isomers of perhydro-norbelladine. On the other hand, trisphaeridine is found promising due to its high hydrogen storage capacity ($\sim$5.9 wt\%) and favorable energetics. Dehydrogenation of perhydro-trisphaeridine has an average standard enthalpy change of $\sim$54 KJ/mol-H$_2$, similar to that of perhydro-\textit{N}-ethylcarbazole, a typical LOHC known for its low dehydrogenation enthalpy. This work is a first exploration of Amaryllidaceae alkaloids for hydrogen storage and the results demonstrate, more generally, the potential of bio-based molecules as a new sustainable resource for future large-scale hydrogen storage.
Identification of a Lacosamide Binding Protein Using an Affinity Bait and Chemical Reporter Strategy: 14-3-3 ζ
Creators: name: Park, Ki Duk
name: Kim, Dongwook
name: Kohn, Harold
name: Eyers, Claire
name: Gaskell, Simon J.
name: Liu, Rihe
name: Reamtong, Onrapak
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We have advanced a useful strategy to elucidate binding partners of ligands (drugs) with modest binding affinity. Key to this strategy is attaching to the ligand an affinity bait (AB) and a chemical reporter (CR) group, where the AB irreversibly attaches the ligand to the receptor upon binding and the CR group is employed for receptor detection and isolation. We have tested this AB&CR strategy using lacosamide ((R)-1), a low-molecular-weight antiepileptic drug. We demonstrate that using a (R)-lacosamide AB&CR agent ((R)-2) 14-3-3 ζ in rodent brain soluble lysates is preferentially adducted, adduction is stereospecific with respect to the AB&CR agent, and adduction depends upon the presence of endogenous levels of the small molecule metabolite xanthine. Substitution of lacosamide AB agent ((R)- 5) for (R)-2 led to the identification of the 14-3-3 ζ adduction site (K120) by mass spectrometry. Competition experiments using increasing amounts of (R)-1 in the presence of (R)-2 demonstrated that (R)-1 binds at or near the (R)-2 modification site on 14-3-3 ζ. Structure-activity studies of xanthine derivatives provided information concerning the likely binding interaction between this metabolite and recombinant 14-3-3 ζ. Documentation of the 14-3-3 ζ-xanthine interaction was obtained with isothermal calorimetry using xanthine and the xanthine analogue 1,7-dimethylxanthine.
Tertium non datur. DC e fine dell’unità politica dei cattolici (1989-1994)
Creators: name: Salvatore, Rosario
Publisher: name: Universita degli studi di Salerno
Year: 2011
Subjects: subject: M-STO/04 STORIA CONTEMPORANEA
subject: Democrazia Cristiana
subject: Politica italiana

description: 2009 - 2010
description: The objective of this research has been the study of the history of the Christian Democracy in the years of the crisis of the system "politico-partitico" during the first Republic. Particularly, through the history and the evolution of the Christian Democracy beNleen the end of the eighties and the beginning of the Ninety, the steps of progressive wear of that peculiar institutional.model are that was translated in the centrality of the in republican Italy "form party". The attention has been focused on failure attempt of the class political democrat-Christian to realize necessary change to infringe the diaphragm that, at least beginning from the seventies, it had prevented or reorganized the abilities of interpretation of the Italian society. The Christian Democracy, in the first republican "quarantennio", had been the party of relative majority and the principal party of government: the disappearance of this function contemporaneously coincide with the collapse of the political system of the same first republic. This consideration, assumed for true, it moves the fulcrum of the attention on a particular aspect of the history and the epilogue of the Christian Democratic. In general, in their meet a series of runs that, in the two years in consideration, they was accomplished, deternilning an explosive and anymore controllable mix from the "dirigenza" of the party, neither enclose into articulate some tides. At the base of the everything, obviously, the are the consequences by fall of the Wall in Berlin, the dissolution of the popular democracies and dissolving of the communist block, that not only they change and not so much the perspective of the Christian Democratic party, how much above all its same reason to be and to exist - with reference to the declination that these had assumed in the republican "quarantennio" - and their positioning to the center of the political-institutional system, over that of the line up "partitico". This overview of the situation (general interpretative key) it is accented to the fund of the to decline him in uncontrolled and unexpected way - in the times, in the ways, in the consequences - of a series of different factors of nature and order, that it assume inferior characteristics for the political, organizational and electoral fabric of the Dc. From the study and from the analysis of the intellectual production of the managing class Christian Democratic, it has emerged, indeed, the need to redefine "the ideal and political run" and "the political unity of the Catholics in the scenery communist post", AS the "they-myths of the ideologies and the horizon of the values", to the light of the "failure of the communism" and of the "end of a political cycle" characterized by a "vote Catholic" and from her "Christian Democratic centrality". .. [edited by Author]
Zr-Co-Al bulk metallic glass composites containing B2 ZrCo via rapid quenching and annealing
Creators: name: Chen, Yu
name: Tang, Chunguang
name: Laws, Kevin
name: Zhu, Qiang
name: Ferry, Michael
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: As a promising remedy for overcoming the limited ductility and work softening of bulk metallic glasses (BMGs), BMG composites incorporating a B2 crystalline phase have attracted considerable attention. Here, we explore the formation of Zr-Co-Al BMG composites by quenching alloys Zr$_{55}$Co$_{31}$Al$_{14}$, Zr$_{54.5}$Co$_{33.5}$Al$_{12}$, Zr$_{53.5}$Co$_{36.5}$Al$_{10}$, Zr$_{52.5}$Co$_{37.5}$Al$_{10}$, and Zr$_{43}$Co$_{43}$Al$_{14}$. We found the first alloy fully amorphous whereas the fifth was fully crystallized upon quenching. The other three were quenched to generate composite structures, with a higher fraction of B2 ZrCo phase with increasing Co/Zr ratio and decreasing Al content. For comparison, the formation of B2 ZrCo in annealed Zr$_{55}$Co$_{31}$Al$_{14}$ was also studied. For both approaches the influence of crystalline phases on hardness was examined.
In Situ Structural Characterization of a Recombinant Protein in Native Escherichia coli Membranes with Solid-State Magic-Angle-Spinning NMR
Creators: name: Li, Conggang
name: Santiago-Miranda, Adriana N.
name: Wang, Xingsheng
name: Fu, Riqiang
name: Pielak, Gary J.
name: Tian, Fang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The feasibility of using solid-state MAS NMR for in situ structural characterization of the LR11 (sorLA) transmembrane domain in native Escherichia coli (E. coli) membranes is presented. LR11 interacts with the human amyloid precursor protein (APP), a central player in the pathology of Alzheimer's disease. The background signals from E. coli lipids and membrane proteins had only minor effects on LR11 TM resonances. Approximately 50% of the LR11 TM residues were assigned by using 13C PARIS data. These assignments allow comparisons of the secondary structure of LR11 TM in native membrane environments and in commonly used membrane mimics (e.g. micelles). In situ spectroscopy bypasses several obstacles in the preparation of membrane proteins for structural analysis, and offers an opportunity to investigate the consequences of membrane heterogeneity, bilayer asymmetry, chemical gradients, and macromolecular crowding on the protein structure.
Kinetic Challenges Facing Oxalate, Malonate, Acetoacetate, and Oxaloacetate Decarboxylases
Creators: name: Wolfenden, Richard
name: Lewis, Charles A.
name: Yuan, Yang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To compare the power of the corresponding enzymes as catalysts, the rates of uncatalyzed decarboxylation of several aliphatic acids (oxalate, malonate, acetoacetate and oxaloacetate) were determined at elevated temperatures and extrapolated to 25 °C. In the extreme case of oxalate, the rate of the uncatalyzed reaction at pH 4.2 was 5 × 10−12 s−1, implying a 2.5 × 1013-fold rate enhancement by oxalate decarboxylase. Whereas the enzymatic decarboxylation of oxalate requires O2 and MnII, the uncatalyzed reaction is unaffected by the presence of these cofactors and appears to proceed by heterolytic elimination of CO2.
ENGLISH COURSE LECTURE NOTE
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2022
Subjects: subject: 200302 English Language
subject: FOS: Languages and literature
subject: 200303 English as a Second Language

description: Category: Languages ​​- English as a Foreign Language & Reference Volume: 2 Year: 2022 Edition: 1 Publisher: Independent Language: English Page: 52 Series name: 2021-2022 Files: PDF, 4.68 MB MAIN LINK: https://id.id1lib.org/book/21264931/e85b7b
Testing the planetary models of HU Aquarii
Creators: name: Bours, M.
name: Marsh, T.
name: Breedt, E.
name: Copperwheat, C.
name: Dhillon, V.
name: Leckngam, A.
name: Littlefair, S.
name: Parsons, S.
name: Prasit, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new eclipse observations of the polar (i.e. semi-detached magnetic white dwarf + M-dwarf binary) HU Aqr, and mid-egress times for each eclipse, which continue to be observed increasingly early. Recent eclipses occurred more than 70 seconds earlier than the prediction from the latest model that invoked a single circumbinary planet to explain the observed orbital period variations, thereby conclusively proving this model to be incorrect. Using ULTRACAM data, we show that mid-egress times determined for simultaneous data taken at different wavelengths agree with each other. The large variations in the observed eclipse times cannot be explained by planetary models containing up to three planets, because of poor fits to the data as well as orbital instability on short time scales. The peak-to-peak amplitude of the O-C diagram of almost 140 seconds is also too great to be caused by Applegate's mechanism, movement of the accretion spot on the surface of the white dwarf, or by asynchronous rotation of the white dwarf. What does cause the observed eclipse time variations remains a mystery.
description: Accepted for publication in MNRAS
AWARENESS AND INFLUENCE OF THE FEDERAL GOVERNMENT'S CASHLESS POLICY ON THE ECONOMY OF THE UYO LOCAL GOVERNMENT AREA, AKWA IBOM STATE, NIGERIA
Creators: name: Udoh, Raphael, Edem
name: Essien, Blessing, Stephen PhD
Publisher: name: SADI Journal
Year: 2025
Subjects: Cashless policy
Federal Government of Nigeria
Awareness
Benefits
Effects

description: 2023 was eventful in Nigeria as it saw Naira buying Naira due to the implementation of the new Naira design and enforcement of the cashless policy. This study investigated the level of awareness and influence of the Federal Government Cashless Policy on the economy of the Uyo Local Government Area of Akwa Ibom State. The study also assessed how the electronic money transfer influenced consumer’s behaviour; how mobile banking affects the inflow and outflow of cash among business owners; and if the electronic money transfer promoted increase banking habit and growth of e-banking, and the negative effects associated with the policy. The study population consisted of employees in Banks, POS Agents, Traders, and Consumers. The sample size for the study was 378 derived using Simple random and purposive sampling techniques. The design for the study was a cross-sectional survey research design using a qualitative approach. The questionnaire and key informant interview (KII) were the major instruments of data collection. Data were analyzed using simple percentages, thematic and content analysis. Findings revealed that most respondents, although actively using electronic banking platforms, online transactions through mobile apps and other banking services, do not know much about cashless policy. The findings also revealed that the cashless policy has drastically reduced the volume of physical cash in circulation. The study recommends among others that: Federal and State Governments through the National Orientation Agency, in collaboration with financial institutions and media houses should increase the campaign and awareness of the cashless policy as awareness is limited. Also, information about the benefits and potential risks of electronic and mobile banking services should be extended to the rural communities who may be uninformed. Banks need to be checkmated by the CBN about their service charges on e-transaction to enhance the full benefits of a cashless environment.
Stable pair invariants on Calabi-Yau threefolds containing P^2
Creators: name: Toda, Yukinobu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14N35, 18E30

description: We relate Pandharipande-Thomas stable pair invariants on Calabi-Yau 3-folds containing the projective plane with those on the derived equivalent orbifolds via wall-crossing method. The difference is described by generalized Donaldson-Thomas invariants counting semistable sheaves on the local projective plane, whose generating series form theta type series for indefinite lattices. Our result also derives non-trivial constraints among stable pair invariants on such Calabi-Yau 3-folds caused by Seidel-Thomas twist.
description: 45 pages
Improving Language Models Meaning Understanding and Consistency by Learning Conceptual Roles from Dictionary
Creators: name: Jang, Myeongjun Erik
name: Lukasiewicz, Thomas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: The non-humanlike behaviour of contemporary pre-trained language models (PLMs) is a leading cause undermining their trustworthiness. A striking phenomenon of such faulty behaviours is the generation of inconsistent predictions, which produces logically contradictory results, such as generating different predictions for texts delivering the same meaning or violating logical properties. Previous studies exploited data augmentation or implemented specialised loss functions to alleviate the issue. However, their usage is limited, because they consume expensive training resources for large-sized PLMs and can only handle a certain consistency type. To this end, we propose a practical approach that alleviates the inconsistent behaviour issue by fundamentally improving PLMs' meaning awareness. Based on the conceptual role theory, our method allows PLMs to capture accurate meaning by learning precise interrelationships between concepts from word-definition pairs in a dictionary. Next, we propose an efficient parameter integration technique that updates only a few additional parameters to combine the learned interrelationship with PLMs' pre-trained knowledge. Our experimental results reveal that the approach can concurrently improve multiple types of consistency, enables efficient knowledge integration, and easily applies to other languages.
description: 15 pages
Very high thermoelectric power factor in a Fe3O4/SiO2/p-type Si(100)heterostructure
Creators: name: Viskadourakis, Z.
name: Paramês, M. L.
name: Conde, O.
name: Zervos, M.
name: Giapintzakis, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The thermoelectric and transport properties of a Fe3O4/SiO2/p-Si(100) heterostructure have been investigated between 100 and 300 K. Both Hall and Seebeck coefficients change sign from negative to positive with increasing temperature while the resistivity drops sharply due to tunneling of carriers into the p-Si(100). The low resistivity and large Seebeck coefficient of Si give a very high thermoelectric power factor of 25.5mW/K2m at 260K which is an underestimated, lower limit value and is related to the density of states and difference in the work functions of Fe3O4 and Si(100) that create an accumulation of majority holes at the p-Si/SiO2 interface
description: 4 pages, 3 figures
Therapeutic use of transcranial Alternating Current Stimulation for Obsessive-Compulsive Disorder
Creators: name: PERERA, MAGELAGE PRABHAVI NILUPULEE
Publisher: name: Monash University
Year: 2023
Subjects: Psychiatry (incl. psychotherapy)
Cognitive neuroscience

description: Obsessive-compulsive disorder (OCD) is a debilitating mental health condition that is difficult to treat. This thesis presents electroencephalographic findings of OCD to broaden our knowledge on the pathophysiology of the disease. Furthermore, a pilot randomised, double-blind, sham-controlled clinical trial was conducted to investigate the use of home-based, individualised transcranial alternating current stimulation (tACS) in the treatment of OCD. The findings provide promising evidence towards the efficacy of tACS in OCD and paves the way to larger studies to ultimately design more effective and reliable applications that offer adequate relief to those affected with OCD.
Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP
Creators: name: Young, Douglas D.
name: Karginov, Andrei V.
name: Zou, Yan
name: Dokholyan, Nikolay V.
name: Kota, Pradeep
name: Hahn, Klaus M.
name: Shirvanyants, David
name: Deiters, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We developed a new system for light-induced protein dimerization in living cells using a novel photocaged analog of rapamycin (pRap) together with an engineered rapamycin binding domain (iFKBP). Using focal adhesion kinase as a target, we demonstrated successful light-mediated regulation of protein interaction and localization in living cells. Modification of this approach enabled light-triggered activation of a protein kinase and initiation of kinase-induced phenotypic changes in vivo.
A Collection of Classroom Instruction
Creators: name: Sarbunan, Thobias
Publisher: name: figshare
Year: 2022
Subjects: subject: 209999 Language, Communication and Culture not elsewhere classified
subject: FOS: Languages and literature
subject: 200301 Early English Languages
subject: 200399 Language Studies not elsewhere classified
subject: Language
subject: 200302 English Language

description: Prologue This information is offering in simple reconstructions to facilitate with the continuation of instructional engagement. This data is adapted from the second literacy base and used in the process of teaching English using simple instructions.
Quantum speed limit of a single atom in a squeezed optical cavity mode
Creators: name: Ma, Ya-Jie
name: Gao, Xue-Chen
name: Wu, Shao-Xiong
name: Yu, Chang-shui
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically study the quantum speed limit of a single atom trapped in a Fabry-Perot microresonator. The cavity mode will be squeezed when a driving laser is applied to the second-order nonlinear medium, and the effective Hamiltonian can be obtained under the Bogoliubov squeezing transformation. The analytical expression of evolved atom state can be obtained by using the non-Hermitian Schrödinger equation for the initial excited state, and the quantum speed limit time coincides very well for both the analytical expression and the master equation method. From the perspective of quantum speed limit, it is more conducive to accelerate the evolution of the quantum state for the large detuning, strong driving and coupling strength. For the initial superposition state case, the form of initial state has more influence on the evolution speed. The quantum speed limit time is not only dependent on the system parameters but also determined by the initial state.
Some Inequalities for the Ratios of Generalized Digamma Functions
Creators: name: Nantomah, Kwara
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33B15, 26A48

description: Some inequalities for the ratios of generalized digamma functions are presented. The approache makes use of the series representations of the $(q,k)$-digamma and $(p,q)$-digamma functions.
description: 5 pages
He-Accreting WDs: accretion regimes and final outcomes
Creators: name: Piersanti, L.
name: Tornambé, A.
name: Yungelson, L. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The behaviour of carbon-oxygen white dwarfs (WDs) subject to direct helium accretion is extensively studied. We aim to analyze the thermal response of the accreting WD to mass deposition at different time scales. The analysis has been performed for initial WDs masses and accretion rates in the range (0.60 - 1.02) Msun and 1.e-9 - 1.e-5 Msun/yr, respectively. Thermal regimes in the parameters space M_{WD} - dot{M}_{He}, leading to formation of red-giant-like structure, steady burning of He, mild, strong and dynamical flashes have been identified and the transition between those regimes has been studied in detail. In particular, the physical properties of WDs experiencing the He-flash accretion regime have been investigated in order to determine the mass retention efficiency as a function of the accretor total mass and accretion rate. We also discuss to what extent the building-up of a He-rich layer via H-burning could be described according to the behaviour of models accreting He-rich matter directly. Polynomial fits to the obtained results are provided for use in binary population synthesis computations. Several applications for close binary systems with He-rich donors and CO WD accretors are considered and the relevance of the results for the interpretation of He-novae is discussed.
description: 25 pages, 17 figures, 12 Tables. Two additional tables are also included (7 pages). Accepted for the publication in MNRAS
Phenomenological correlations in high-temperature superconductors
Creators: name: Fiolhais, Miguel C. N.
name: Birman, Joseph L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: An interpretation of the quadratic parameter of the Ginzburg-Landau theory of superconductivity is presented in this paper. The negative term in the potential, which allows the spontaneous symmetry breaking, is interpreted as a direct contribution from the energy gap at the Fermi surface to the effective potential. As a result, in the London approximation of the Ginzburg-Landau theory for type-II superconductors, a strong correlation is predicted and observed between the upper critical field at zero kelvin and the critical temperature in high temperature superconductors.
description: 4 pages, 2 figures
Label-free Imaging of Catalytic H2O2 Decomposition on Single Colloidal Pt Nanoparticles using Nanofluidic Scattering Microscopy
Creators: name: Altenburger, Björn
name: Andersson, Carl
name: Levin, Sune
name: Westerlund, Fredrik
name: Fritzsche, Joachim
name: Langhammer, Christoph
Publisher: name: arXiv
Year: 2023
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Single particle catalysis aims at determining factors that dictate nanoparticle activity and selectivity. Existing methods often use fluorescent model reactions at low reactant concentrations, operate at low pressures, or rely on plasmonic enhancement effects. Hence, methods to measure single nanoparticle activity at technically relevant conditions, and without fluorescence or other enhancement mechanisms, are still lacking. Here, we introduce nanofluidic scattering microscopy to fill this gap. By detecting minuscule refractive index changes in a liquid flushed through a nanochannel, we demonstrate that local H2O2 concentration changes in water can be accurately measured. Applying this principle, we analyze the H2O2 concentration profiles adjacent to single colloidal Pt nanoparticles during catalytic H2O2 decomposition into O2 and H2O and derive the particles individual turnover frequencies from the growth rate of O2 gas bubbles formed in their respective nanochannel during reaction.
Macromolecular Crowding Fails To Fold a Globular Protein in Cells
Creators: name: Millet, Oscar
name: Schlesinger, Alexander P.
name: Tadeo, Xavier
name: Pielak, Gary J.
name: Wang, Yaqiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Proteins perform their function in cells where macromolecular solutes reach concentrations of >300 g/L and occupy >30% of the volume. The volume excluded by these macromolecules will stabilize globular proteins because the native state occupies less space than the denatured state. Theory predicts that crowding can increase the ratio of folded to unfolded protein by a factor of 100, amounting to 3 kcal/mol of stabilization at room temperature. We tested the idea that volume exclusion dominates the crowding effect in cells with a variant of protein L, a 7-kDa globular protein with seven lysine residues replaced by glutamic acids. Eighty-four percent of the variant molecules populate the denatured state in dilute buffer at room temperature, compared to 0.1% for the wild-type protein. We then used in-cell nuclear magnetic resonance spectroscopy to show that the cytoplasm of Escherichia coli does not overcome even this modest (~1 kcal/mol) free energy deficit. The data are consistent with the idea that non-specific interactions between cytoplasmic components can overcome the excluded volume effect. Evidence for these interactions is provided by the observation that adding simple salts folds the variant in dilute solution, but increasing the salt concentration inside E. coli does not fold the protein. Our data are consistent with other studies of protein stability in cells, and suggest that stabilizing excluded volume effects, which must be present under crowded conditions, can be ameliorated by non-specific interactions between cytoplasmic components.
Polarity Inversion of Donor–Acceptor Cyclopropanes: Disubstituted δ-Lactones via Enantioselective Iridium Catalysis
Creators: name: Moran, Joseph
name: Johnson, Jeffrey S.
name: Krische, Michael J.
name: Carris, Ryan M.
name: Smith, Austin G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The coupling of carbonyl electrophiles at the donor position of donor-acceptor cyclopropanes is described, representing an inversion of polarity with respect to conventional reactivity modes displayed by these reagents. Specifically, upon exposure of donor-acceptor cyclopropanes to alcohols in the presence of a cyclometallated iridium catalyst modified by (S)-BINAP, catalytic C-C coupling occurs to provide enantiomerically enriched products of carbonyl allylation. Identical products are obtained upon isopropanol mediated transfer hydrogenation of donor-acceptor cyclopropanes in the presence of aldehydes. The reaction products are directly transformed to cis-4,5-disubstituted δ-lactones.
Florida Cucumbers and Green Peppers: Production, Marketing Patterns, Prices, and Margins
Creators: name: Burns, Alfred J.
name: Podany, Joseph C.
name: Burns, Alfred J.
name: Podany, Joseph C.
Publisher: name: Unknown
Year: 1975
Subjects: subject: Crop Production/Industries
subject: Demand and Price Analysis
subject: International Relations/Trade
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Productivity Analysis
subject: Cucumbers
subject: green peppers
subject: production
subject: marketing
subject: prices
subject: margins
subject: Florida
subject: Mexico

description: Florida is the leading domestic producer of many fall, winter, and spring vegetables. Increased competition from Mexican imports has hurt the Florida industry and, for some vegetables, has threatened the States's position as the major U.S. supplier. This report traces trends in production, marketing, prices, margins, and grower returns for Florida cucumbers and green peppers.
description: Reprinted from The Vegetable Situation • May 1975
Designed Compounds for Recognition of 10 Base Pairs of DNA with Two AT Binding Sites
Creators: name: Liu, Yang
name: Chai, Yun
name: Wilson, W. David
name: Tidwell, Richard R.
name: Boykin, David W.
name: Kumar, Arvind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Short AT base pair sequences that are separated by a small number of GCs are common in eukaryotic parasite genomes. Cell-permeable compounds that bind effectively and selectively to such sequences present an attractive therapeutic approach. Compounds with linked, one or two amidine-benzimidazole-phenyl (ABP) motifs were designed, synthesized and evaluated for binding to adjacent AT sites by biosensor-surface plasmon resonance (SPR). A surprising feature of the linked ABP motifs is that a set of six similar compounds has three different minor groove binding modes with the target sequences. Compounds with one ABP bind independently to two separated AT sites. Unexpectedly, compounds with two ABP motifs can bind strongly either as monomers or as cooperative dimers to the full site. The results are supported by mass spectrometry and circular dichroism, and models to explain the different binding modes are presented.
Delayed-Input and Non-Malleable Cryptographic Protocols
Creators: name: Siniscalchi, Luisa
Publisher: name: Universita degli studi di Salerno
Year: 2018
Subjects: subject: INF/01 INFORMATICA
subject: Proof system
subject: Non-malleability
subject: Delayed-input
subject: Properties

description: 2016 - 2017
description: A major goal in the design of cryptographic protocols is to re- duce the number of communication rounds. Since a cryptographic protocol usually consists of a composition and interplay of some subprotocols and cryptographic primitives, the natural approach to save rounds consists in playing all subprotocols in parallel. Un- fortunately this approach often fails since a subprotocol in order to start could require as input the output of another subprotocol. In such cases the two subprotocols must be played sequentially therefore penalizing the overall round complexity. In this thesis we provide delayed-input cryptographic protocols that can be played in parallel with other subprotocols even in the above scenario where the output of a subprotocol is required as input by the other subprotocol. We show the actual impact of our delayed-input cryptographic protocols by improving the round e ciency of various applications... [edited by Author]
Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles
Creators: name: Parrott, Matthew C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm x 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and therefore the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.