cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Performance based design and evaluation of reinforced concrete bridges
Creators: name: Zhang, Qi
Publisher: name: University of British Columbia
Year: 2015

description: Performance based design (PBD) has been deemed as one of the most promising design methods in the past few decades. It reduces the uncertainties underline the tradition force based design (FBD) and acts as an efficient communication tool between technical and non-technical people. Canadian Highway Bridge Design Code (CHBDC) has initiated PBD in Canada in 2014, which brought in one of the biggest changes to the new version of the design code. For Lifeline bridges and irregular Major Route bridges, the code requires PBD to be used to explicitly demonstrate structural performance. As per the code, Regular Major Route bridges can be designed by using either FBD or PBD method. In this study, a multi-bent concrete highway bridge is designed using both FBD and PBD based on CHBDC 2014, and FBD based on CHBDC 2006. The evaluation of different designs is performed to determine which method is more conservative. Soil-structure interaction is incorporated using p-y method in the design and analysis. Dynamic time-history analyses are performed to assess the seismic performance. The assessment is based on the maximum strain limits from CHBDC 2014. The results reveal that the PBD in CHBDC 2014 is highly conservative in comparison with FBD in current and previous design codes. This is because CHBDC 2014 requires rebar yielding shall not happen at 1/475-year earthquake event. Eliminating rebar yielding at 1/475-year event may be very challenging to achieve in high seismic regions and 1/475-year event may dominate other design levels. After performing the PBD, a displacement based design approach is also used to examine the performance criteria from the code. It is shown that by using displacement based approach the PBD could be simplified for regular bridges. Additionally, a series of charts of column drift versus steel strain are presented to facilitate future engineering designs. At the end, the methodology of the next generation PBD is utilized to compare the seismic performance of bridges in terms of engineering demand parameters and decision variables.
Remarks on the notion of quantum integrability
Creators: name: Caux, J. -S.
name: Mossel, J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss the notion of integrability in quantum mechanics. Starting from a review of some definitions commonly used in the literature, we propose a different set of criteria, leading to a classification of models in terms of different integrability classes. We end by highlighting some of the expected physical properties associated to models fulfilling the proposed criteria.
description: 22 pages, no figures, Proceedings of Statphys 24
Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma
Creators: name: Xia, Y.
name: Xu-Monette, Z. Y.
name: Tzankov, A.
name: Li, X.
name: Manyam, G. C.
name: Vundavalli, Murty V.
name: Bhagat, Govind
name: Zhang, S.
name: Pasqualucci, Laura
name: Visco, C.
name: Dybkaer, K.
name: Chiu, A.
name: Orazi, A.
name: Zu, Y.
name: Richards, K. L.
name: Hsi, E. D.
name: Choi, W. W. L.
name: Van Krieken, J. H.
name: Huh, J.
name: Ponzoni, M.
name: Ferreri, A. J. M.
name: Møller, M. B.
name: Parsons, B. M.
name: Winter, J. N.
name: Piris, M. A.
name: Westin, J.
name: Fowler, N.
name: Miranda, R. N.
name: Ok, C. Y.
name: Li, Y.
name: Li, J.
name: Medeiros, L. J.
name: Young, K. H.
Publisher: name: Columbia University
Year: 2016
Subjects: Genomics
Cancer--Genetic aspects
Lymphomas
Bcl-2 protein family
Prognosis

description: PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrations and relevant clinical implications. A large series of patients with de novo DLBCL was effectively evaluated for PRDM1/BLIMP-1 deletion, mutation, and protein expression. BLIMP-1 expression was frequently associated with the ABC phenotype and plasmablastic morphologic subtype of DLBCL, yet 63% of the ABC-DLBCL patients were negative for BLIMP-1 protein expression. In these patients, loss of BLIMP-1 was associated with Myc overexpression and decreased expression of p53 pathway molecules. In addition, homozygous PRDM1 deletions and PRDM1 mutations within exons 1 and 2, which encode for domains crucial for transcriptional repression, were found to show a poor prognostic impact in patients with ABC-DLBCL but not in those with germinal center B-cell-like DLBCL (GCB-DLBCL). Gene expression profiling revealed that loss of PRDM1/BLIMP-1 expression correlated with a decreased plasma-cell differentiation signature and upregulation of genes involved in B-cell receptor signaling and tumor-cell proliferation. In conclusion, these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients.
CRF-based Disfluency Detection using Semantic Features for German to English Spoken Language Translation
Creators: name: Cho, Eunah
name: Ha, Thanh-Le
name: Waibel, Alex
Publisher: name: Association for Computational Linguistics (ACL)
Year: 2013

description: Disfluencies in speech pose severe difficulties in machine translation of spontaneous speech. This paper presents our conditional random field (CRF)-based speech disfluency detection system developed on German to improve spoken language translation performance. In order to detect speech disfluencies considering syntactics and semantics of speech utterances, we carried out a CRF-based approach using information learned from the word representation and the phrase table used for machine translation. The word representation is gained using recurrent neural networks and projected words are clustered using the k-means algorithm. Using the output from the model trained with the word representations and phrase table information, we achieve an improvement of 1.96 BLEU points on the lecture test set. By keeping or removing humanannotated disfluencies, we show an upper bound and lower bound of translation quality. In an oracle experiment we gain 3.16 BLEU points of improvement on the lecture test set, compared to the same set with all disfluencies.
Stage Staffing Scheme for Copyright Protection in Multimedia
Creators: name: Kumar, Sumit
name: Kumar, Santosh
name: Nandi, Sukumar
Publisher: name: arXiv
Year: 2011
Subjects: subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Copyright protection has become a need in today's world. To achieve a secure copyright protection we embedded some information in images and videos and that image or video is called copyright protected. The embedded information can't be detected by human eye but some attacks and operations can tamper that information to breach protection. So in order to find a secure technique of copyright protection, we have analyzed image processing techniques i.e. Spatial Domain (Least Significant Bit (LSB)), Transform Domain (Discrete Cosine Transform (DCT)), Discrete Wavelet Transform (DWT) and there are numerous algorithm for watermarking using them. After having a good understanding of the same we have proposed a novel algorithm named as Stage Staffing Algorithm that generates results with high effectiveness, additionally we can use self extracted-watermark technique to increase the security and automate the process of watermark image. The proposed algorithm provides protection in three stages. We have implemented the algorithm and results of the simulations are shown. The various factors affecting spatial domain watermarking are also discussed.
description: 13 pages, 7 figures
The efficacy and acceptability of prenatal Corn Soya Blend Plus dietary supplementation among women in rural Cambodia
Creators: name: Janmohamed, Amynah
Publisher: name: University of British Columbia
Year: 2015

description: Corn Soya Blend (CSB) Plus is a micronutrient-fortified dietary supplement designed for women in Cambodia and elsewhere to help meet their nutritional needs in pregnancy, though little is known about its acceptance and ability to improve pregnancy outcomes. This research utilized a mixed methods approach to investigate the efficacy and acceptability of prenatal supplementation with CSB Plus among rural Cambodian women. A cluster-randomized trial was conducted in 75 villages in Kampong Chhnang Province, in which 547 women received the food supplement (treatment) on a monthly basis from the first trimester until delivery or continued their normal diet (control). Participants included women receiving antenatal care at a health facility in the first trimester. The primary outcome was birth weight and secondary outcomes were low birth weight (< 2500 grams), small for gestational age, birth length and head circumference, preterm birth (< 37 weeks), maternal weight gain, and anemia prevalence at 24-28, 30-32, and 36-38 weeks gestation. Cluster-adjusted linear mixed effect and logistic regression models were used to examine group differences. Acceptability of CSB Plus was investigated through structured interviews to understand consumption preferences and practices and six focus group discussions to explore perceptions, attitudes, and behaviors related to supplement utilization. CSB Plus resulted in a non-significant 46 g increase in birth weight (95% CI: -31, 123) and did not increase maternal weight gain or other measures of birth size. However, maternal anemia at 36-38 weeks (OR: 0.51; 95% CI: 0.34, 0.77) and preterm birth (OR: 0.33; 95% CI: 0.12, 0.89) were lower in the CSB Plus group. A significantly higher rate of fetal loss occurred in the treatment group. Acceptability was influenced by the product’s organoleptic qualities, family support, peer influences, trust in the provider of the supplement, and attitudes related to nutrition and weight in pregnancy. Acceptance was lower among first-time mothers, mainly due to fears of a large baby and resulting delivery complications. The findings of this research provide insight that can be used to guide future policy and programming decisions on the provision of Corn Soya Blend Plus and other prenatal dietary supplements in the Cambodian context.
The experience of having a partner in prison—A systematic review and meta-ethnography
Creators: name: McDonnell, Darren
name: Lambert, Sharon
name: Farrell, Aoife
Publisher: name: University of Limerick
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology

description: The number of individuals in prison is increasing worldwide. More and more family members are impacted by the imprisonment of a loved one. They face a variety of difficulties, such as social exclusion, mental health difficulties, stigma, and isolation. A systematic review and meta-ethnography were carried out using Noblit & Hare's seven-step approach to bring together the qualitative research in this area and support policy recommendations. Key databases were searched systematically and 12 studies, with varying aims, sample, and location, were included. The synthesis produced six core themes, reflecting the experiences of partners (mainly female): Role Transitions; Loss and Isolation; Shame and Secrecy; Encounters with the Prison Systems; Silver Linings; New Ways of Coping. The overarching narrative that integrates the findings suggests that the experience of having a partner in prison is a process of resocialisation. Partners not only conform to new circumstances and adjust their behaviour, but also adjust to changes in their roles and responsibilities, relationships, positions in society, and their futures. The findings, not with-standing limitations and recommendations for future research, highlight the need for healthcare professionals, community and prison services, and policymakers to work together to support this population in their resocialisation process. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Space storm measurements of the July 2005 solar extreme events from the low corona to the Earth
Creators: name: Caroubalos, C.
name: Preka-Papadema, P.
name: Mavromichalaki, H.
name: Moussas, X.
name: Papaioannou, A.
name: Mitsakou, E.
name: Hillaris, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Athens Neutron Monitor Data Processing (ANMODAP) Center recorded an unusual Forbush decrease with a sharp enhancement of cosmic ray intensity right after the main phase of the Forbush decrease on 16 July 2005, followed by a second decrease within less than 12 h. This exceptional event is neither a ground level enhancement nor a geomagnetic effect in cosmic rays. It rather appears as the effect of a special structure of interplanetary disturbances originating from a group of coronal mass ejections (CMEs) in the 13-14 July 2005 period. The initiation of the CMEs was accompanied by type IV radio bursts and intense solar flares (SFs) on the west solar limb (AR 786); this group of energetic phenomena appears under the label of Solar Extreme Events of July 2005. We study the characteristics of these events using combined data from Earth (the ARTEMIS IV radioheliograph, the Athens Neutron Monitor (ANMODAP)), space (WIND/WAVES) and data archives. We propose an interpretation of the unusual Forbush profile in terms of a magnetic structure and a succession of interplanetary shocks interacting with the magnetosphere.
description: Advances in Space Research, Volume 43, Issue 4, p. 600-604
Additional file 1 of Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study
Creators: name: Tchoukalova, Yourka D.
name: Zacharias, Stephanie R. C.
name: Mitchell, Natalie
name: Madsen, Cathy
name: Myers, Cheryl E.
name: Gadalla, Dina
name: Skinner, Jessica
name: Kopaczka, Katarzyna
name: Gramignoli, Roberto
name: Lott, David G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Pathway analysis report.
Clérigos regulares nas ordenações sacras da Sé de Coimbra no século XV
Creators: name: Gomes, Saul António
Publisher: name: Lusitania Sacra
Year: 2005

description: Neste artigo, o Autor, partindo do estudo das matrículas de ordens sacras da Sé de Coimbra, existentes entre os anos de 1399 e 1491, avalia a evolução demográfica geral do Clero nesta Diocese e as linhas sociológicas estruturantes que caracterizavam todo o “processo de clericalização” desde a recepção da primeira tonsura até à obtenção do presbiterado. Incide, depois, sobre o clero regular presente, avaliando a representatividade dos professos das velhas Ordens monásticas (Cónegos Regrantes, Beneditinos, Cistercienses e religiosos das Ordens Militares de Avis e de Cristo), bem como o elevadíssimo peso, posto que não surpreendente na história eclesiástica medieval portuguesa, dos claustrais das novas Ordens (Dominicanos, Franciscanos, Jerónimos, Eremitas Agostinhos e Trinitários), as quais atravessavam, em Quatrocentos, um período de profunda recomposição, de que se recolhem importantes e inéditos ecos nas fontes arquivísticas em causa.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Time Delay in Swiss Cheese Gravitational Lensing
Creators: name: Chen, Bin
name: Kantowski, Ronald
name: Dai, Xinyu
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We compute time delays for gravitational lensing in a flat LambdaCDM Swiss cheese universe. We assume a primary and secondary pair of light rays are deflected by a single point mass condensation described by a Kottler metric (Schwarzschild with Lambda) embedded in an otherwise homogeneous cosmology. We find that the cosmological constant's effect on the difference in arrival times is non-linear and at most around 0.002% for a large cluster lens; however, we find differences from time delays predicted by conventional linear lensing theory that can reach ~4% for these large lenses. The differences in predicted delay times are due to the failure of conventional lensing to incorporate the lensing mass into the mean mass density of the universe.
description: 10 pages, 2 figures, submitted
Credibility-like Shrinkage in Linear Models for Pricing and Reserving
Creators: name: Venter, Gary
Publisher: name: Columbia University
Year: 2019
Subjects: Actuarial science
Bayesian statistical decision theory
Credibility theory (Insurance)
Spline theory

description: This is an introduction to Bayesian shrinkage in semi-parametric models for actuaries. It starts with a link of the James-Stein estimator to an actuarial estimation approach known as credibility, and shows that by shrinking estimates towards the overall mean, the predictive variance is reduced. Then it argues that ridge regression and lasso achieve a similar improvement in predictive variance also by shrinking estimates towards the overall mean, but now by shrinking regression coefficients. This can be done more simply and directly by a fully Bayesian approach. Semi-parametric regression can also be simplified by shrinking slope changes of linear splines using the fully Bayesian method. This is illustrated by building curves across parameters of the same type in regression models, some resembling age-period-cohort models.
A quem são teúdos os barões e sages cónegos? Perspectivas sobre as redes de solidariedade no Cabido da Sé de Lisboa (1277-1377)
Creators: name: Farelo, Mário
Publisher: name: Lusitania Sacra
Year: 2005

description: Este texto sobre as redes de solidariedade tecidas no cabido catedralício de Lisboa entre 1277 e 1377 pretende identificar os órgãos de poder (Bispo, Cúria pontifícia, família régia, oligarquia urbana) presentes no seu recrutamento social através da observação das relações funcionais mantidas com os capitulares. Para este desiderato foram retidos os conceitos de parentesco e de clientelismo, os quais surgem aqui como conceitos operatórios de base.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Science Circus Pacific, Hands-on Online Workshop Booklet, Asia-Pacific
Creators: name: Walker, Graham
name: Duggan, Joe
name: Nakano, Isla
Publisher: name: The Australian National University
Year: 2021
Subjects: Science Communication
Engagement
Asia Pacific
Remote

description: Many students think science is something that happens in textbooks, which is sad because textbooks aren’t much fun. The result is bored unmotivated students who don’t learn as well – learning works best when it is fun and hands-on. This booklet was compiled from the UNESCO Hands-on Online Asia Pacific 2021 workshop series. The activities presented here were submitted by participants of the program competition, or were presented by guest lecturers in the workshop series. The activities here can be used directly with students as class activities, or used as demonstrations by teachers. Please note though, that some of these activities are more dangerous than others. Take extra care where CAUTION is noted. Some activities are not suitable for students to try themselves. This book contains a range of fun science activities and accompanying videos that can be done with everyday items – things that are either low-cost or free. Science Circus Pacific’s approach to science learning draws on inquiry-based learning pedagogy and gives participants the opportunity to recognize the relevance of Science Technology, Engineering and Maths (STEM) to their everyday lives. We want students to work with their hands, collaborate and share ideas and importantly, test things out, learn from failures and innovate. We believe learning works best for students when it is fun and hands-on!
Nepotismo e poder na Arquidiocese de Braga (1245-1374)
Creators: name: Costa, Maria Antonieta Moreira Da
Publisher: name: Lusitania Sacra
Year: 2005

description: O estudo do nepotismo no seio da Igreja Católica da Idade Média tem atraído alguns investigadores alemães, ingleses e italianos, mas no caso português são poucos os autores que mencionam esta prática, dedicando-lhe apenas vagas referências em obras de carácter geral. Actualmente, o conhecimento do uso deste costume pode trazer à luz do dia uma outra realidade para além da tradicional história política e institucional do Estado Pontifício. Pode revelar-nos outros canais de exercício do poder eclesiástico: os constituídos pelo complexo de relações sócio-políticas e culturais, tanto clientelares como familiares e, ainda, o extraordinário crescimento em influência dos grupos aristocratas junto da Cúria Papal ou em geral, pois para além dos sumos-pontífices, também cardeais, bispos, abades, cónegos e outros clérigos abundantemente o praticaram. Ainda que dentro de uma cronologia limitada, este artigo analisa o tema relativamente à sé de Braga, onde foi possível confirmar este poderoso poder relacional através de redes bem definidas como a dos Portocarreiro ou a dos Pereira.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Bilayer manganites: polarons in the midst of a metallic breakdown
Creators: name: Massee, F.
name: Huang, S. de Jong. Y.
name: Siu, W. K.
name: Santoso, I.
name: Mans, A.
name: Boothroyd, A. T.
name: Prabhakaran, D.
name: Follath, R.
name: Varykhalov, A.
name: Patthey, L.
name: Shi, M.
name: Goedkoop, J. B.
name: Golden, M. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The exact nature of the low temperature electronic phase of the manganite materials family, and hence the origin of their colossal magnetoresistant (CMR) effect, is still under heavy debate. By combining new photoemission and tunneling data, we show that in La{2-2x}Sr{1+2x}Mn2O7 the polaronic degrees of freedom win out across the CMR region of the phase diagram. This means that the generic ground state is that of a system in which strong electron-lattice interactions result in vanishing coherent quasi-particle spectral weight at the Fermi level for all locations in k-space. The incoherence of the charge carriers offers a unifying explanation for the anomalous charge-carrier dynamics seen in transport, optics and electron spectroscopic data. The stacking number N is the key factor for true metallic behavior, as an intergrowth-driven breakdown of the polaronic domination to give a metal possessing a traditional Fermi surface is seen in the bilayer system.
description: 7 pages, 2 figures, includes supplementary information
Kinetics of sulphide conversion to thiosulphate and gold dissolution study by electrochemical quartz crystal microbalance
Creators: name: Melashvili, Mariam
Publisher: name: University of British Columbia
Year: 2015

description: The kinetics of the oxidation of pyrite sulphide to a thiosulphate reaction were studied using a pyrite concentrate oxidized in an alkaline medium at an oxygen overpressure between 10 and 40 psig at a temperature of 80ºC. Sodium hydroxide was used to neutralize the acid produced as a result of the pyrite oxidation. The focus of this study was the calculation of thiosulphate yield as a function of sulphide sulphur concentration of the pyrite in the feed. A single rate expression combining kinetic constants of all the metastable oxyanions was derived to predict the thiosulphate yield as a function of the known pyrite sulphide sulphur concentration under the experimental conditions that were adopted. [formula omitted] It was found that at 20 psig oxygen overpressure and a temperature of 80ºC, the initial rate of sulphide oxidation and thiosulphate yield was close to 0.08 mol/h and 0.015 mol/h, respectively, at pH values greater than 12. However, a shift from linearity occurred when the pH decreased below 12. It was observed in the experiments that any decrease in pH was accompanied by an increase in solution potential, which enhanced the rate of gold leaching provided sufficient thiosulphate remained in the solution. The oxidation and reduction of gold in thiosulphate as a function of applied potential was studied using cyclic voltammetry. The responses of cyclic voltammetry of gold electrodes in thiosulphate were compared under different conditions involving catalysts such as thallium and thiourea. It was found that the gold anodic current increases in the presence of catalysts which is more likely to be related to the adsorption/desorption phenomenon and not to the depletion of the thiosulphate ion at the reaction interface. Higher anodic current increased the surface gold concentration available for reduction. The large anodic-to-cathodic peak separation that ranged from 0.25V to 0.37V allowed most of the leached gold to diffuse away from the electrode. This indicates the electrochemically-irreversible character of this system even in the presence of catalysts. The relationship between the reduction peak current and concentration of gold thiosulphate in the bulk electrolyte was estimated based on a relevant equation for electrochemically-irreversible reaction.
Additional file 2 of Recombinant anti-Müllerian hormone in the maturation medium improves the in vitro maturation of human immature (GV) oocytes after controlled ovarian hormonal stimulation
Creators: name: Bedenk, Jure
name: Režen, Tadeja
name: Železnik Ramuta, Taja
name: Jančar, Nina
name: Vrtačnik Bokal, Eda
name: Geršak, Ksenija
name: Virant Klun, Irma
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Average age, BMI, FSH and LH levels of patients whose oocytes were used for IVM. Differences between groups were not statistically significant (ANOVA).
A Viela dos Cónegos: o espaço e os homens de uma rua do Porto na Idade Média (1221-1493)
Creators: name: Silva, Maria João Oliveira E
Publisher: name: Lusitania Sacra
Year: 2005

description: Em finais de 1185 uma série de reformas de carácter administrativo e religioso alteraram o modo de vida dos cónegos do Porto que desde a restauração da diocese (1112-1114) tinham vivido em comunidade no claustro da Sé. Desde então os cónegos passaram a viver de forma secular sem, no entanto, se afastarem da sua catedral. Pela proximidade à “casa-mãe” mas também pela boa localização no próprio Morro da Sé, a Viela dos Cónegos cedo foi escolhida para residência da conezia. De facto, foram os cónegos, e principalmente o cabido, os grandes proprietários desta rua. E por essa razão o cabido foi também gestor. Proprietários e inquilinos, na maior parte dos casos eclesiásticos, viviam em simples “casas”, casas sobradadas e até casas-torre. Uma destas ainda hoje se conhece e se identifica pelo nome de um dos seus mais ilustres proprietários: Afonso Luís, cónego da Sé do Porto.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Thermal Properties of Graphene, Carbon Nanotubes and Nanostructured Carbon Materials
Creators: name: Balandin, Alexander A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent years witnessed a rapid growth of interest of scientific and engineering communities to thermal properties of materials. Carbon allotropes and derivatives occupy a unique place in terms of their ability to conduct heat. The room-temperature thermal conductivity of carbon materials span an extraordinary large range - of over five orders of magnitude - from the lowest in amorphous carbons to the highest in graphene and carbon nanotubes. I review thermal and thermoelectric properties of carbon materials focusing on recent results for graphene, carbon nanotubes and nanostructured carbon materials with different degrees of disorder. A special attention is given to the unusual size dependence of heat conduction in two-dimensional crystals and, specifically, in graphene. I also describe prospects of applications of graphene and carbon materials for thermal management of electronics.
description: Review Paper; 37 manuscript pages; 4 figures and 2 boxes
Mechanisms of exertional dyspnea in postsurgical patients with non-small cell lung cancer
Creators: name: Harper, Megan
Publisher: name: University of British Columbia
Year: 2015

description: Background: Dyspnea is a debilitating symptom reported by patients with non-small cell lung cancer (NSCLC) after pulmonary resection. Reduced ventilatory capacity and respiratory muscle weakness associated with surgery could lead to an imbalance between ventilatory effort and output (a phenomenon known as neuromechanical uncoupling [NMU]) and result in dyspnea. Additionally, augmented pulmonary vascular resistance may impair left ventricular (LV) stroke volume (SV), and contribute to dyspnea and exercise intolerance. It was therefore hypothesized that greater NMU would be associated with dyspnea and exercise intolerance in NSCLC. It was also hypothesized that reduced diastolic filling and decreased LV SV would be associated with dyspnea and exercise intolerance in NSCLC. Methods: Using a cross-sectional design, thirteen post-surgical NSCLC patients performed a pulmonary function test and an incremental cardiopulmonary exercise test, followed by constant-load cycling exercise at 25%, 50%, and 75% Wmax. At 75% Wmax, patients exercised until symptom limitation. The sensory intensity, unpleasantness and sensory qualities of dyspnea were measured during exercise using the modified Borg scale and the multidimensional dyspnea profile. Ventilatory parameters, esophageal pressures, and operational lung volumes were measured continuously; echocardiography was employed during the constant-load trials. Healthy, sedentary age and sex-matched individuals were selected from our database for comparison to the NSCLC group. Results: Patients with NSCLC reported greater intensity of dyspnea for a given power output when compared to controls, particularly during higher intensity exercise. NMU was unchanged throughout exercise despite significant reductions in ventilatory capacity (p<0.05). There was a significant correlation between the resting E/A and exercise tolerance (r² = 0.58; p = 0.035); however, there were no significant correlations observed between ventilatory or cardiovascular parameters and dyspnea or exercise tolerance. Conclusion: In contrast to our hypothesis, we observed no evidence of NMU during exercise in NSCLC. The lack of association between ventilatory parameters and dyspnea suggests that the mechanisms of dyspnea are different from those previously identified in other respiratory diseases. The primary constraint to exercise appeared to be ventilatory limitation secondary to reduced ventilatory capacity and increased ventilatory demand due to peripheral deconditioning. Therapeutic interventions that improve aerobic capacity and reduce ventilatory drive are now warranted with the ultimate aim of reducing dyspnea in this population.
An updated catalog of M31 globular-like clusters: UBVRI photometry, ages, and masses
Creators: name: Fan, Zhou
name: de Grijs, Richard
name: Zhou, Xu
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present an updated UBVRI photometric catalog containing 970 objects in the field of M31, selected from the Revised Bologna Catalog (RBC v.4.0), including 965, 967, 965, 953, and 827 sources in the individual UBVRI bands, respectively, of which 205, 123, 14, 126, and 109 objects do not have previously published photometry. Photometry is performed using archival images from the Local Group Galaxies Survey, which covers 2.2 deg^2 along the major axis of M31. We focus on 445 confirmed `globular-like' clusters and candidates, comprising typical globular and young massive clusters. The ages and masses of these objects are derived by comparison of their observed spectral-energy distributions with simple stellar population synthesis. Approximately half of the clusters are younger than 2 Gyr, suggesting that there has been significant recent active star formation in M31, which is consistent with previous results. We note that clusters in the halo (r_ projected>30kpc) are composed of two different components, older clusters with ages >10 Gyr and younger clusters with ages around 1 Gyr. The spatial distributions show that the young clusters (<2 Gyr) are spatially coincident with the galaxy's disk, including the `10 kpc ring,' the `outer ring,' and the halo of M31, while the old clusters (> 2 Gyr) are spatially correlated with the bulge and halo. We also estimate the masses of the 445 confirmed clusters and candidates in M31 and find that our estimates agree well with previously published values. We find that none of the young disk clusters can survive the inevitable encounters with giant molecular clouds in the galaxy's disk and that they will eventually disrupt on timescales of a few Gyr. Specifically, young disk clusters with a mass of 10^4 M_\odot are expected to dissolve within 3.0 Gyr and will, thus, not evolve to become globular clusters.
description: 35 pages, 20 figures and 5 tables, accepted for publication in ApJ
Additional file 3 of Recombinant anti-Müllerian hormone in the maturation medium improves the in vitro maturation of human immature (GV) oocytes after controlled ovarian hormonal stimulation
Creators: name: Bedenk, Jure
name: Režen, Tadeja
name: Železnik Ramuta, Taja
name: Jančar, Nina
name: Vrtačnik Bokal, Eda
name: Geršak, Ksenija
name: Virant Klun, Irma
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. The average age of donor women distributed between the groups of in vitro matured oocytes and immature or mature oocytes. There was no significant difference.
Topics in statistical data analysis for high-energy physics
Creators: name: Cowan, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: These lectures concern two topics that are becoming increasingly important in the analysis of High Energy Physics (HEP) data: Bayesian statistics and multivariate methods. In the Bayesian approach we extend the interpretation of probability to cover not only the frequency of repeatable outcomes but also to include a degree of belief. In this way we are able to associate probability with a hypothesis and thus to answer directly questions that cannot be addressed easily with traditional frequentist methods. In multivariate analysis we try to exploit as much information as possible from the characteristics that we measure for each event to distinguish between event types. In particular we will look at a method that has gained popularity in HEP in recent years: the boosted decision tree (BDT).
description: 22 pages, Lectures given at the 2009 European School of High-Energy Physics, Bautzen, Germany, 14-27 Jun 2009
Enhanced surface melting of the Fennoscandian Ice Sheet during periods of North Atlantic cooling
Creators: name: Boswell, Steven M.
name: Toucanne, Samuel
name: Pitel-Roudaut, Mathilde
name: Creyts, Timothy T.
name: Eynaud, Frédérique
name: Bayon, Germain
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: Glaciology
subject: Ice sheets
subject: Climatic changes

description: Heinrich events (HEs) are dramatic episodes of marine-terminating ice discharge and sediment rafting during periods of cold North Atlantic climate. However, the causal chain of events leading to their occurrence is unresolved. Here, we demonstrate that enhanced surface melting of land-terminating margins of the southern Fennoscandian Ice Sheet (FIS) is a recurring feature of Heinrich stadials (HSs), the cold periods during which HEs occur. We use neodymium isotopes to show that the Channel River transported detrital sediments from the interior of eastern Europe to the Bay of Biscay in the northeast Atlantic Ocean at ca. 158–154 ka. Based on similar evidence from the last glacial period, we infer that this interval corresponds to the melting and retreat of the southern FIS margin despite contemporaneous cooling in the North Atlantic and central Europe. The FIS melting episode occurred just prior to a HE, consistent with findings from the more recent HSs 1, 2, and 3. Based on this evidence, we clarify a sequence of events that precedes HEs. Precursor melting of North Atlantic–adjacent ice sheets induces an initial Atlantic meridional overturning circulation (AMOC) slowdown. Atmospheric changes during the resulting HS cause summertime warming in northern Europe that drives enhanced FIS melting. Subsequent meltwater discharge to the North Atlantic further weakens the AMOC and warms the intermediate water masses that contribute to HEs.
As abadessas cistercienses na Idade Média: identificação, caracterização e estudo de trajectórias individuais ou familiares
Creators: name: Rêpas, Luís Miguel
Publisher: name: Lusitania Sacra
Year: 2005

description: Este artigo parte da caracterização do cargo abacial e das funções que lhe estavam inerentes para depois evoluir em torno da seguinte questão: que critérios orientavam a escolha de uma abadessa cisterciense na Idade Média? A identificação de algumas preladas e a apresentação de determinadas trajectórias individuais ou familiares permitem concluir que o poder e o prestígio que o exercício daquele cargo podia proporcionar a essas religiosas e às suas famílias motivaram insistentes interferências das linhagens na vida comunitária, sendo aqui colocadas em destaque as pressões exercidas aquando de cada nova eleição. Ingerências que, por serem inaceitáveis aos olhos de parte da comunidade conventual, ou porque a dividiam em clãs rivais, acabavam por originar complicados e demorados processos de contestação. Da presente análise transparece a permeabilidade das comunidades monásticas ao exterior e o entretecer de relações de solidariedade, baseadas no parentesco alargado e na constituição de clientelas, cujo sucesso acaba por justificar a perpetuação do governo de uma abadia nas mãos de uma mesma família ao longo de várias gerações.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Additional file 4 of Recombinant anti-Müllerian hormone in the maturation medium improves the in vitro maturation of human immature (GV) oocytes after controlled ovarian hormonal stimulation
Creators: name: Bedenk, Jure
name: Režen, Tadeja
name: Železnik Ramuta, Taja
name: Jančar, Nina
name: Vrtačnik Bokal, Eda
name: Geršak, Ksenija
name: Virant Klun, Irma
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Average cell fluorescence (ACF) measured in different groups of oocytes: immature, mature and control oocytes.
The impact of pharmaceutical innovation on the burden of disease in Canada, 2000-2016
Creators: name: Lichtenberg, Frank R.
Publisher: name: Columbia University
Year: 2019
Subjects: Public health
Drug development
Drugs--Cost effectiveness
Health status indicators

description: We perform an econometric assessment of the role that pharmaceutical innovation—the introduction and use of new drugs—has played in reducing the burden of disease in Canada, by investigating whether diseases for which more new drugs were launched had larger subsequent reductions in disease burden. Since utilization of a drug reaches a peak about 12-14 years after it was launched, we allow for considerable lags in the relationship between new drug launches and the burden of disease. We analyze the impact of new drug launches on a comprehensive measure of disease burden—the age-standardized disability-adjusted life-years lost (DALY) rate—and on its two components: the age-standardized years of life lost (YLL) and years lost to disability (YLD) rates. We also analyze the impact of new drug launches on the number of hospital discharges and on the average length of hospital stays. The number of DALYs lost is significantly inversely related to the number of drugs that had ever been launched 9-20 years earlier, and the number of YLLs is significantly inversely related to the number of drugs that had ever been launched 11-20 years earlier. The launch of a drug has the largest (most negative) impact on the number of DALYs and YLLs 15 years after it was launched. The estimates indicate that if no drugs had been launched during 1986-2001, the age-standardized DALY rate would not have declined between 2000 and 2016; it might even have increased. Almost all (93%) of the reduction in DALYs was due to a reduction in YLL. The estimates imply that new drug launches during 1986-2001 reduced DALYs in 2016 by 21%, reduced YLLs in 2016 by 28%, and reduced YLDs in 2016 by 3%. We estimate that drugs launched during 1986-2001 reduced the number of DALYs lost in 2016 by 2.31 million. Expenditure in 2016 on drugs launched during 1986-2001 per DALY gained in 2016 from those drugs was 2842 USD. Interventions that avert one DALY for less than average per capita income for a given country or region are generally considered to be very cost–effective; Canada’s per capita GDP was 42,158 USD in 2016, so our estimates indicate that the new drugs launched during 1986-2001 were very cost–effective, overall. Moreover, 2842 USD may be an overestimate of the true net cost in 2016 per DALY of drugs launched during 1986-2001. A previous study based on U.S. data showed that about 25% of the cost of new drugs is offset by reduced expenditure on old drugs. Also, our estimates indicate that, if no drugs had been launched during 1986-2001, the average length of 2016 hospital stays would have been about 16% higher. The reduction in hospital expenditure due to shorter average length of stay may have been larger than the expenditure on the drugs responsible for shorter hospital stays.
Cavaleiros de Cristo, monges, frades e eremitas: um percurso pelas formas de vida religiosa em Évora durante a Idade Média (sécs. XII a XV).
Creators: name: Fontes, João Luís Inglês
Publisher: name: Lusitania Sacra
Year: 2005

description: O presente artigo procura traçar um percurso pelas diferentes formas de vida religiosa presentes em Évora, desde a conquista cristã da cidade, em 1165, até aos alvores da modernidade. Seguindo, em larga medida, a própria cronologia das fundações, procura-se explicitar as circunstâncias em que estas ocorreram, o que caracteriza o modo de vida das respectivas ordens e a forma como estas se relacionam com a cidade. À presença inicial das ordens militares, garante da defesa de uma cidade de fronteira, suceder-se-á, já na segunda metade do século XIII, a implantação das ordens mendicantes e de uma comunidade cisterciense, numa cidade agora em crescimento. Chegados ao século XV, a urbe espelha as contradições destes finais da Idade Média, entre fundações ligadas a ordens reformistas, como os Jerónimos ou os Lóios, a outras mais tradicionais, como as Clarissas. A par destas, a presença dos eremitas da Serra de Ossa ou de numerosas comunidades de mulheres da pobre vida revela a vitalidade de um espaço alternativo de vida religiosa, procurado sobretudo pelos leigos, fora dos tradicionais enquadramentos monásticos.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval
Guerra e Santidade: o cavaleiro-mártir Henrique de Bona e a conquista cristã de Lisboa
Creators: name: Pereira, Armando De Sousa
Publisher: name: Lusitania Sacra
Year: 2005

description: A conquista cristã de Lisboa, em 1147, suscitou a escrita de numerosos testemunhos, desde curtos registos analísticos a longas e detalhadas narrativas, destinados a transmitir e enaltecer, na Cristandade latina, a memória de um dos poucos sucessos militares da Segunda Cruzada. Proveniente do cartório do Mosteiro de S. Vicente, um desses textos, de provável origem teutónica, destaca o martírio dos cruzados mortos em combate contra o Islão, centrando-se particularmente em Henrique de Bona e na descrição dos respectivos milagres no contexto da tomada da cidade e posterior ordenação da mesma sob o domínio do rei de Portugal. O propósito deste estudo consiste em delinear, partindo da escassa informação disponível em textos coevos e posteriores, os mecanismos de construção de uma memória sagrada deste cavaleiro, também nomeado como Popteto Ulvinga em crónicas frísias dos séculos XIII a XV, e recolher os traços de um eventual culto a ele dedicado.
description: Lusitania Sacra, n. 17 (2005): Clérigos e Religiosos na Sociedade Medieval