cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ion Pair Potentials-of-Mean-Force in Water
Creators: name: Pratt, Lawrence R.
name: Hummer, Gerhard
name: Garcia, Angel E.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Recent molecular simulation and integral equation results alkali-halide ion pair potentials-of-mean-force in water are discussed. Dielectric model calculations are implemented to check that these models produce that characteristic structure of contact and solvent-separated minima for oppositely charged ions in water under physiological thermodynamic conditions. Comparison of the dielectric model results with the most current molecular level information indicates that the dielectric model does not, however, provide an accurate description of these potentials-of-mean-force. We note that linear dielectric models correspond to modelistic implementations of second-order thermodynamic perturbation theory for the excess chemical potential of a distinguished solute molecule. Therefore, the molecular theory corresponding to the dielectric models is second-order thermodynamic perturbation theory for that excess chemical potential. The second-order, or fluctuation, term raises a technical computational issue of treatment of long-ranged interactions similar to the one which arises in calculation of the dielectric constant of the solvent. It is contended that the most important step for further development of dielectric models would be a separate assessment of the first-order perturbative term (equivalently the {\it potential at zero charge} ) which vanishes in the dielectric models but is generally nonzero. Parameterization of radii and molecular volumes should then be based of the second-order perturbative term alone. Illustrative initial calculations are presented and discussed.
description: 37 pages and 8 figures. LA-UR-93-4205
Novel markers of plaque rupture in patients with chest pain
Creators: name: Bajrangee, Amrit
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Chest pain presentations to the accident and emergency department account for approximately 20% of admissions. Determining those patients at high risk of plaque rupture the squeal of which is ischemia and myocardial necrosis continues to be clinically challenging. Current clinical pathways identify those who have undergone plaque rupture utilizing cardiac troponins and electrocardiogram changes but this confirms plaque rupture after myocardial injury. We previously identified a number of proteins in an Apolipoprotien B mouse model that were present at significantly higher or lower levels in the serum prior to plaque rupture and thus were predictive of a higher risk of plaque rupture in mice. None of these proteins had been identified in plaque rupture previously. My MD thesis evaluated the clinical utility of these markers in an unselected cohort of 203 patients presenting with chest pain to either the accident and emergency department or cardiac catheterization suite at St James’s Hospital, Dublin. We found that Galectin 3 was significantly elevated in patients with cardiac chest pain i.e. stable angina and acute coronary syndrome (ACS). In ACS patients Galectin 3 was significantly elevated prior to plaque rupture and correlated with the duration of symptoms. IL-15Rα was significantly elevated in patients presenting both with stable angina and ACS.IL-15Rα was also elevated prior to plaque rupture and thrombosis in patients with unstable angina. This correlated strongly with the duration of symptoms suggesting its utility as a marker of unstable plaque. IL-15Rα also correlated significantly with Gal-3 in patients with ACS, specifically in those with unstable angina with unstable plaque. TGFIIβR was significantly elevated in patients with stable angina and decreased in those with unstable symptoms but did not correlate with the duration of chest pain symptoms. The other markers DTK and HF7 were not significantly elevated and found not to be predictive of unstable plaque.
Additional file 9: of Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits
Creators: name: Ding, Haisheng
name: Zhao, Huiling
name: Cheng, Guanglong
name: Yang, Yongxin
name: Wang, Xiaofei
name: Zhao, Xiaowei
name: Qi, Yunxia
name: Huang, Dongwei
Publisher: name: figshare
Year: 2019
Subjects: Cell Biology
Biological Sciences not elsewhere classified
Developmental Biology

description: Figure S7. Analyses of SNPs annotation. A L1 B L2 C L3 D S1 E S2 F S3. (PDF 355 kb)
The Black Hole Masses and Eddington Ratios of Type 2 Quasars
Creators: name: Kong, Minzhi
name: Ho, Luis C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Type 2 quasars are an important constituent of active galaxies, possibly representing the evolutionary precursors of traditionally studied type 1 quasars. We characterize the black hole mass ($M_{\rm BH}$) and Eddington ratio ($L_{\rm bol}/L_{\rm Edd}$) for 669 type 2 quasars selected from the Sloan Digital Sky Survey, using black hole masses estimated from the $M_{\rm BH}-σ_{\ast}$ relation and bolometric corrections scaled from the extinction-corrected $ [\rm O~{\scriptsize III}]~ λ5007$ luminosity. When stellar velocity dispersions cannot be measured directly from the spectra, we estimate them from the core velocity dispersions of the narrow emission lines $ \rm [O~{\scriptsize II}]~ λλ3726, 3729$, $ \rm [S~{\scriptsize II}]~λλ6716, 6731$, and $[ \rm O~{\scriptsize III}]~ λ5007$, which are shown to trace the gravitational potential of the stars. Energy input from the active nucleus still imparts significant perturbations to the gas kinematics, especially to high-velocity, blueshifted wings. Nonvirial motions in the gas become most noticeable in systems with high Eddington ratios. The black hole masses of our sample of type 2 quasars range from $M_{\rm BH} \approx 10^{6.5} $ to $10^{10.4} \, M_\odot$ (median $10^{8.2} \, M_\odot$). Type 2 quasars have characteristically large Eddington ratios ($L_{\rm bol}/L_{\rm Edd}~\approx 10^{-2.9}-10^{1.8}$; median $10^{-0.7}$), slightly higher than in type~1 quasars of similar redshift; the luminosities of $\sim$20% of the sample formally exceed the Eddington limit. The high Eddington ratios may be consistent with the notion that obscured quasars evolve into unobscured quasars.
description: 23 pages, 12 figures, ApJ, accepted
Production of Three Vector Bosons in e+e- Annihilation as a Test of W+-, Z, gamma Self-Interactions
Creators: name: Grosse-Knetter, C.
name: Schildknecht, D.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the vector-boson production processes e+e- --> WWZ and e+e- -->WWgamma which are directly affected by the trilinear and quadrilinear self couplings of the W, Z and gamma. Our analysis is based upon a single-parameter effective-Lagrangian model for these self interactions which contains the standard model as a special case. Consequences for the phenomenology at an e+e- collider of 500 GeV (NLC) are discussed, and fits of the free parameter around its standard model value are carried out.
description: BI-TP 92/30, July 1992 (Enlarged Version October 1992) One section added to the old version. Figures (unchanged) no more included but available by request
SOME FACETS OF HUMAN RESOURCE MANAGEMENT IN THE INDUSTRIAL ORGANIZATIONS IN BULGARIA AFTER THE PRIVATIZATION
Creators: name: Dimitrov, Kiril
Publisher: name: figshare
Year: 2018
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business
subject: 150305 Human Resources Management
subject: 150311 Organisational Behaviour

description: The current article presents a part of the results of empirical survey, conducted to explore the condition of human resource management in the privatized industrial organizations in our country. The generated results may assist the surveyed companies’ managers in their pursuit of high level organization’s competitiveness after Bulgaria’s unification with the European Union members.
Option Pricing Models Driven by the Space-Time Fractional Diffusion: Series Representation and Applications
Creators: name: Aguilar, Jean-Philippe
name: Korbel, Jan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Finance (q-fin.MF)
subject: FOS: Economics and business

description: In this paper, we focus on option pricing models based on space-time fractional diffusion. We briefly revise recent results which show that the option price can be represented in the terms of rapidly converging double-series and apply these results to the data from real markets. We focus on estimation of model parameters from the market data and estimation of implied volatility within the space-time fractional option pricing models.
Geographical variation in incidence of first episode psychosis by place at birth vs place at onset and relationship to the social environment in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS)
Creators: name: Omer, Sami
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Little is known about associations between the social environment and risk for psychosis within rural settings. This study sought to investigate whether such associations exist within an essentially rural context using a prospective dataset of unusual epidemiological completeness. Using the Cavan-Monaghan First Episode Psychosis Study database of people aged 16 years and older, both ecological analyses and multilevel modelling were applied to investigate associations between incidence of psychosis by both place at onset and place at birth and socio-environmental risk factors of material deprivation, social fragmentation and urban-rural classification across electoral divisions. For place at onset, the primary finding was an association between more deprived social contexts and higher rates of psychotic disorder, after adjustment for age and sex [all psychoses: incidence rate ratio (IRR) =1.12 (95% CI 1.03-1.23)]. These findings support an association between adverse socioenvironmental factors and increase in risk for psychosis by place at onset within an essentially rural environment. This study suggests that poorer social environments, rather than urbanicity per se, may be relevant to the incidence of psychosis, though such exposures may have greater impact in more urban settings.
Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology
Creators: name: Huck, Simon
name: Bock, Josephine
name: Girardello, Jörg
name: Gauert, Marc
name: Pul, Ümit
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: In this communication, we report the adaptation of the CRISPR-Cas9 technology in Ustilago trichophora prototrophic wild-type isolate obtained from its natural host Echinochloa crus-galli. The established CRISPR vector and method enable a rapid and marker-free introduction of Cas9-induced non-homologous end-joining (NHEJ) dependent mutation at the targeted gene. Moreover, the method allows a specific modification of the chromosomal DNA sequence by Cas9-induced homologous recombination using short DNA repair templates. The results demonstrate the applicability of the CRISPR-Cas9 technology in U. trichophora for both gene knock-out by the NHEJ pathway and specific gene modification by templated genome editing, paving the way for rapid metabolic engineering of this Ustilago species for industrial applications.
Optical Bistability in a Low Photon-Density Regime
Creators: name: Shirai, Tatsuhiko
name: Todo, Synge
name: de Raedt, Hans
name: Miyashita, Seiji
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We give a microscopic description of the optical bistability, where the transmission coefficient has two different values as a function of input light intensity, and the system exhibits a discontinuous jump with a hysteresis loop. We developed an efficient numerical algorithm to treat the quantum master equation for hybridized systems of many photons and a large number of two-level atoms. By using this method, we characterize the bistability from the viewpoint of eigenmodes and eigenvalues of the time evolution operator of the quantum master equation. We investigate the optical bistability within the low photon-density regime, where the hybridization of photon and atom degrees of freedom occurs and the resonance spectrum has a double peak structure. We compared it with the standard optical bistability between the low photon-density regime and the high photon-density regime, where the photons can be treated as a classical electromagnetic field and the resonance spectrum has a single peak structure. We discuss the steady-state properties of the optical bistability: dependencies of the photon number density on the intensity and the double peak structure of the photon number distribution inside the bistable region. As for the dynamical properties, we find that the relaxation timescale shows an exponential growth with the system size, and reveal how the hysteresis loop of the optical bistability depends on the size of the system and the sweeping rate of the driving amplitude. Finally, by investigating the effects of detuning frequency of the input field, we clarify the characteristic properties of the present optical bistability within the low photon-density regime, which are qualitatively different from the standard optical bistable phenomena.
description: 14 pages
Tests of Dielectric Model Descriptions of Chemical Charge Displacements in Water
Creators: name: Tawa, Gregory J.
name: Pratt, Lawrence R.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A dielectric model of electrostatic solvation is applied to describe potentials of mean force in water along reaction paths for: a) formation of a sodium chloride ion pair; b) the symmetric SN2 exchange of chloride in methylchloride; and c) nucleophilic attack of formaldehyde by hydroxide anion. For these cases simulation and XRISM results are available for comparison. The accuracy of model predictions varies from spectacular to mediocre. It is argued that: a) dielectric models are physical models, even though simplistic and empirical; b) their successes suggest that second-order perturbation theory is a physically sound description of free energies of electrostatic solvation; and c) the most serious deficiency of the dielectric models lies in the definition of cavity volumes. Second-order perturbation theory should therefore be used to refine the dielectric models. These dielectric models make no attempt to assess the role of packing effects but for solvation of classical electrostatic interactions the dielectric models sometimes perform as well as the more detailed XRISM theory.
description: 12 pages and 4 figures, LA-UR-94431
Observation of a Group of Dark Rogue Waves in a Telecommunication Optical Fiber
Creators: name: Baronio, F.
name: Frisquet, B.
name: Chen, S.
name: Millot, G.
name: Wabnitz, S.
name: Kibler, B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Over the past decade, the rogue wave debate has stimulated the comparison of predictions and observations among different branches of wave physics, particularly between hydrodynamics and optics, in situations where analogous dynamical behaviors can be identified, thanks to the use of common universal models. Although the scalar nonlinear Schroedinger equation (NLSE) has constantly played a central role for rogue wave investigations, moving beyond the standard NLSE model is relevant and needful for describing more general classes of physical systems and applications. In this direction, the coupled NLSEs are known to play a pivotal role for the understanding of the complex wave dynamics in hydrodynamics and optics. Benefiting from the advanced technology of high-speed telecommunication-grade components, and relying on a careful design of the nonlinear propagation of orthogonally-polarized optical pump waves in a randomly birefringent telecom fiber, this work explores, both theoretically and experimentally, the rogue wave dynamics governed by such coupled NLSEs. We report, for the first time, the evidence of a group of three dark rogue waves, the so-called dark three-sister rogue waves, where experiments, numerics, and analytics show a very good consistency.
Phase-Space Decoherence: a comparison between Consistent Histories and Environment Induced Superselection
Creators: name: Twamley, J.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We examine the decoherence properties of a quantum open system as modeled by a quantum optical system in the Markov regime. We look for decoherence in both the Environment Induced Superselection (EIS) and Consistent Histories (CH) frameworks. We propose a general measure of the coherence of the reduced density matrix and find that EIS decoherence occurs in a number of bases for this model. The degree of ``diagonality'' achieved increases with bath temperature. We evaluate the Decoherence Functional of Consistent Histories for coarse grained phase space two-time projected histories. Using the measures proposed by Dowker and Halliwell we find that the consistency of the histories improves with increasing bath temperature, time and final grain size and decreases with initial grain size. The peaking increases with increasing grain size and decreases with increasing bath temperature. Adopting the above proposed measure of ``coherence'' to the Decoherence Functional gives similar results. The results agree in general with expectations while the anomalous dependence of the consistency on the initial grain size is discussed.
description: 27 pages, 5 postscript figs in uuencoded compressed tar format Replaced: definition of special character for the complex numbers
Field-driven transition in the Ba$_{1-x}$K$_x$Fe$_2$As$_2$ superconductor with splayed columnar defects
Creators: name: Park, Akiyoshi
name: Pyon, Sunseng
name: Ohara, Kengo
name: Ito, Nozomu
name: Tamegai, Tsuyoshi
name: Kambara, Tadashi
name: Yoshida, Atsushi
name: Ichinose, Ataru
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Through 2.6 GeV U irradiations, we have induced bimodal splayed columnar defects in Ba$_{1-x}$K$_x$Fe$_2$As$_2$ single crystals with splay angles, $\pm 5 ^\circ$, $\pm 10 ^\circ$, $\pm 15 ^\circ$, and $\pm 20 ^\circ$. Critical current densities through magnetization measurements were carefully evaluated, where a splay angle of $\pm 5 ^\circ$ brought about the highest $J_\mathrm{c}$. Mageto-optical images close to $T_\mathrm{c}$ indicates highly anisotropic discontinuity lines in the remnant state, and with anisotropy increasing with greater splay angles. Moreover, amongst those with splayed columnar defects, anomalous non-monotonic field dependences of $J_\mathrm{c}$ and $S$ with an extrema at some fraction of the matching field are observed. We discuss that such $J_\mathrm{c}$ enhancement arises from a field-driven coupling transition in which intervortex interactions reorganize the vortex structure to be accommodated into columnar defects, thereby increasing pinning at higher fields.
description: 12 pages, 13 figures
Fermi/LAT observations of Lobe-dominant Radio Galaxy 3C 207 and Possible Radiation Region of the Gamma-Rays
Creators: name: Guo, Sheng-Chu
name: Zhang, Hai-Ming
name: Zhang, Jin
name: Liang, En-Wei
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: 3C 207 is a lobe-dominant radio galaxy with one sided jet and the bright knots in kpc-Mpc scale were resolved in the radio, optical and X-ray bands. It was confirmed as a gamma-ray emitter with Fermi/LAT, but it is uncertain whether the gamma-ray emission region is the core or knots due to the low spatial resolution of Fermi/LAT. We present an analysis of its Fermi/LAT data in the past 9 years. Different from the radio and optical emission from the core, it is found that the gamma-ray emission is steady without detection of flux variation over 2 sigma confidence level. This likely implies that the gamma-ray emission is from its knots. We collect the radio, optical, and X-ray data of knot-A, the closest knot from the core at 1 arcsec, and compile its spectral energy distribution (SED). Although the single-zone synchrotron+SSC+IC/CMB model by assuming knot-A at rest can reproduce the SED in the radio-optical-X-ray band, the predicted gamma-ray flux is lower than the LAT observations and the derived magnetic field strength deviates the equipartition condition with 3 orders of magnitude. Assuming that knot-A is relativistically moving, its SED from radio to gamma-ray bands would be well represented with the single-zone synchrotron+SSC+IC/CMB model under the equipartition condition. These results likely suggest that the gamma-ray emission may be from knot-A via the IC/CMB process and the knot should have relativistical motion. The jet power derived from our model parameters is also roughly consistent with the kinetic power estimated with the radio data.
description: 7 pages, 2 figures, accepted for publication in RAA
$CP$ violating mode of the stoponium decay into $Zh$
Creators: name: Cheung, Kingman
name: Keung, Wai-Yee
name: Tseng, Po-Yan
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that a novel decay mode $Zh$ of the bound state of stop-anti-stop pair in the ground state $^1S_0(\widetilde t_1\widetilde t_1^*)$ may have a significant branching ratio if the $CP$ violating mixing appears in the stop sector, even after we apply the stringent constraint from the measurement of the electric dipole moment (EDM) of the electron. We show that the branching ratio can be as large as 10% in some parameter space that it may be detectable at the LHC.
description: 16 pages, 4 figures
Generalized Dimensional Analysis
Creators: name: Georgi, Howard
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I describe a version of so-called naive dimensional analysis, a rule for estimating the sizes of terms in an effective theory below the scale of chiral symmetry breaking induced by a strong gauge interaction. The rule is simpler and more general than the original, which it includes as a special case. I also give a simple qualitative interpretation of the rule.
description: 5 pages, LATEX
Supplementary Information from An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose
Creators: name: Johnston, Stuart T.
name: Faria, Matthew
name: Crampin, Edmund J.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 10202 Biological Mathematics
subject: FOS: Mathematics
subject: 100799 Nanotechnology not elsewhere classified
subject: FOS: Nanotechnology

description: Contains model and solution derivation, method of solution, experimental details and experimental data.
Quantum Annealing: A New Method for Minimizing Multidimensional Functions
Creators: name: Finnila, A. B.
name: Gomez, M. A.
name: Sebenik, C.
name: Stenson, C.
name: Doll, J. D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Quantum annealing is a new method for finding extrema of multidimensional functions. Based on an extension of classical, simulated annealing, this approach appears robust with respect to avoiding local minima. Further, unlike some of its predecessors, it does not require an approximation to a wavefunction. In this paper, we apply the technique to the problem of finding the lowest energy configurations of Lennard-Jones clusters of up to 19 particles (roughly 10$^5$ local minima). This early success suggests that this method may complement the widely implemented technique of simulated annealing.
Additional file 1 of Chromosome-scale assembly and annotation of the perennial ryegrass genome
Creators: name: Nagy, Istvan
name: Veeckman, Elisabeth
name: Liu, Chang
name: Bel, Michiel Van
name: Vandepoele, Klaas
name: Jensen, Christian Sig
name: Ruttink, Tom
name: Asp, Torben
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 Table S1. Pseudo-chromosome sizes of the L. perenne v2.6.1 assembly compared to homologous pseudo-chromosomes of two recent assemblies of H. vulgare cv. Morex: IBSC_PGSB_v2 (Mascher et al., 2017) and Morex_V2 (Monat et al., 2019). Table S2. Transposons and repeats detected by RepeatMasker in the L. perenne genome using the Liliopsida species model. Table S3. SSR repeats identified in the L. perenne genome. Table S4. Short non-coding RNA types identified in the L. perenne genome. Table S5. Chromosomal mapping of 10,368 single-copy orthologs on pseudo-chromosomes of L. perenne P226 and barley (Morex_V2). Table S6. Protein families identified by profile-based searches in barley and perennial ryegrass using Morex_V2 and Lolium_2.6.1 (v3) annotations. Fig. S1. Hi-C contact map with Lolium_2.6.1 reference sequences. Fig. S2. Age distribution of transposon types in the L. perenne genome. Fig. S3. BUSCO completeness scores of the v3 annotation. Fig. S4. Pairwise whole-genome alignments of pseudo-chromosomes of L. perenne. Fig. S5. Phylogenetic tree of the CONSTANS/VRN2 gene family with complete gene names.
The Role of Competitive Glycosaminoglycan Binding in Determining the Inflammatory Profile of the Cystic Fibrosis Airway
Creators: name: Williamson, Michael
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Lung disease of cystic fibrosis (CF) is aggravated by intense airway inflammation with high concentrations of chemotactic interleukin (IL)-8 protected from proteolytic degradation by binding to glycosaminoglycans (GAGs). In contrast IL-18 is mostly absent from the CF airways. The aim of this project was to compare these two pro-inflammatory cytokines for their relative stability, activity, and interaction with GAGs. Further, the ability of increased hypertonicity, induced by hypertonic saline (HTS) treatment, to alter IL-8 interaction with GAGs both ex vivo and in vitro was investigated. Raised levels of IL-8 and reduced concentrations of IL-18 were detected in airway secretions from CF individuals. Pro- and mature forms of IL-18 were expressed and produced normally by CF epithelial cells and monocytes; however, a marked competition between IL-8 and IL-18 for binding to GAGs was demonstrated. A pronounced loss of IL-18 binding occurred in the presence of IL-8, with displaced IL-18 rendered susceptible to proteolysis by neutrophil elastase. In turn, GAG lysis in CF BALF displaced bound IL-8, allowing IL-8 proteolytic degradation. High sodium concentrations also liberate IL-8 in CF BALF and in CF sputum from patients receiving nebulised HTS, resulting in IL-8 degradation and decreased chemotactic efficiency. In conclusion, the potential of GAGs to influence the chemokine profile of the CF lung by stabilizing specific inflammatory mediators has been demonstrated. Competition from IL-8 determines the fate of other inflammatory molecules, such as IL-18, within the CF lung inflammatory milieu. A novel mechanism has been identified highlighting the potential of nebulised HTS to decrease neutrophil chemotaxis, facilitating resolution of inflammation.
Supplementary Material of Predicted and Measured Concentration of Pharmaceuticals in the Serchio Basin, Italy
Creators: name: Cardini Alessio
name: Elisa, Pellegrino
name: Rossetto Rudy
name: Ercoli Laura
Publisher: name: Zenodo
Year: 2021
Subjects: rural area
periurban area
urban area
PEC
MEC

description: Supplementary Material of the article entitled "Predicted and Measured Concentration of Pharmaceuticals in the Serchio Basin, Italy"
Single photon emission from graphene quantum dots at room temperature
Creators: name: Zhao, S.
name: Lavie, J.
name: Rondin, L.
name: Orcin-Chaix, L.
name: Diederichs, C.
name: Roussignol, Ph.
name: Chassagneux, Y.
name: Voisin, C.
name: Müllen, K.
name: Narita, A.
name: Campidelli, S.
name: Lauret, J. S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In the field of condensed matter, graphene plays a central role as an emerging material for nanoelectronics. Nevertheless, graphene is a semimetal, which constitutes a severe limitation for some future applications. Therefore, a lot of efforts are being made to develop semiconductor materials whose structure is compatible with the graphene lattice. In this perspective, little pieces of graphene represent a promising alternative. In particular, their electronic, optical and spin properties can be in principle controlled by designing their size, shape and edges. As an example, graphene nanoribbons with zigzag edges have localized spin polarized states. Likewise, singlet-triplet energy splitting can be chosen by designing the structure of graphene quantum dots. Moreover, bottom-up molecular synthesis put these potentialities at our fingertips. Here, we report on a single emitter study that directly addresses the intrinsic properties of a single graphene quantum dot. In particular, we show that graphene quantum dots emit single photons at room temperature with a high purity, a high brightness and a good photostability. These results pave the way to the development of new quantum systems based on these nanoscale pieces of graphene.
Nucleon Decay in the Minimal Supersymmetric $SU(5)$ Grand Unification
Creators: name: Hisano, J.
name: Murayama, H.
name: Yanagida, T.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We make a detailed analysis on the nucleon decay in the minimal supersymmetric $SU(5)$ grand unified model. We find that a requirement of the unification of three gauge coupling constants leads to a constraint on a mass $M_{H_C}$ of color-triplet Higgs multiplet as $2 \times 10^{13}~\GeV \leq M_{H_C} \leq 2 \times 10^{17}~\GeV$, taking both weak- and GUT-scale threshold effects into account. Contrary to the results in the previous analyses, the present experimental limits on the nucleon decay turn out to be consistent with the SUSY particles lighter than 1~TeV even without a cancellation between matrix elements contributed from different generations, if one adopts a relatively large value of $M_{H_C}$ ($\ge2\times 10^{16}~\GeV$). We also show that the Yukawa coupling constant of color-triplet Higgs multiplet does not necessarily blow up below the gravitational scale ($2.4\times10^{18}~\GeV$) even with the largest possible value of $M_{H_C}$. We point out that the no-scale model is still viable, though it is strongly constrained.
description: 45 pages
Additional file 1: of Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens
Creators: name: Lam, Phuong
name: Padula, Stephanie
name: Hoang, Thanh
name: Poth, Justin
name: Liu, Lin
name: Liang, Chun
name: LeFever, Adam
name: Wallace, Lindsay
name: Ashery-Padan, Ruth
name: Riggs, Penny
name: Shields, Jordan
name: Shaham, Ohad
name: Rowan, Sheldon
name: Brown, Nadean
name: Glaser, Tom
name: Robinson, Michael
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Developmental Biology
subject: Virology

description: Figure S1. FISH analysis using a probe for CRE labeled in red and a mouse BAC probe (RP24-257H11) labeled in green. Mitotic chromosome spreads from fibroblasts established from the last living homozygous transgenic mouse from the second founder (RD6) created with the identical DNA construct that established the Le-Cre transgenic line. An idiogram of mouse chromosome 10 with the location of transgene insertion (green arrowhead) is shown on the idiogram at the left of the FISH image. White arrows point to the overlapping FISH signals on each of the copies of chromosome 10. The idiogram was taken from the Idiogram Album by David Adler ÂŠ 1994. (PDF 235 kb)
Genetic diversity and population connectivity of the sea urchin Tripneustes gratilla along the South African coast
Creators: name: M Brink
name: R Dale Kuys
name: C Rhode
name: BM Macey
name: KW Christison
name: R Roodt-Wilding
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The collector sea urchin Tripneustes gratilla has been identified as a species with potential for aquaculture production in South Africa. The species’ roe is considered a culinary delicacy in Asia and Europe. However, T. gratilla remains genetically uncharacterised in South Africa. Therefore, the purpose of this study was to provide baseline genetic information consisting of estimates of genetic diversity and population stratification, which may aid in future sustainable use of this urchin resource. A total of 22 species-specific microsatellite markers were used for the genetic characterisation of T. gratilla samples from along the South African coast, at Haga Haga, Coffee Bay, Hibberdene, Ballito Bay and Sodwana Bay. A moderate level of genetic diversity was observed, with an average number of alleles of 7.89 and an average effective number of alleles of 6.57, as well as an average observed heterozygosity of 0.55. Population differentiation tests suggest that the geographically representative samples form part of a single, large interbreeding population, with a global Fst estimate of 0.02 (p > 0.05). This finding is likely explained by high levels of gene flow between these locations caused by extensive larval dispersal during the planktonic larval stage. The panmixia observed within these natural populations of T. gratilla indicate that they could be managed as a single genetic stock.
Local and global gravitational aspects of domain wall space-times
Creators: name: Cvetič, Mirjam
name: Griffies, Stephen
name: Soleng, Harald H.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Local and global gravitational effects induced by eternal vacuum domain walls are studied. We concentrate on thin walls between non-equal and non-positive cosmological constants on each side of the wall. These vacuum domain walls fall in three classes depending on the value of their energy density $σ$: (1)\ extreme walls with $σ= σ_{\text{ext}}$ are planar, static walls corresponding to supersymmetric configurations, (2)\ non-extreme walls with $σ= σ_{\text{non}} > σ_{\text{ext}}$ correspond to expanding bubbles with observers on either side of the wall being {\em inside\/} the bubble, and (3)\ ultra-extreme walls with $σ= σ_{\text{ultra}} < σ_{\text{ext}}$ represent the bubbles of false vacuum decay. On the sides with less negative cosmological constant, the extreme, non-extreme, and ultra-extreme walls exhibit no, repulsive, and attractive effective ``gravitational forces,'' respectively. These ``gravitational forces'' are global effects not caused by local curvature. Since the non-extreme wall encloses observers on both sides, the supersymmetric system has the lowest gravitational mass accessable to outside observers. It is conjectured that similar positive mass protection occurs in all physical systems and that no finite negative mass object can exist inside the universe. We also discuss the global space-time structure of these singularity free space-times and point out intriguing analogies with the causal structure of black holes.
description: UPR-565-T, 26 REVTEX pages, 10 figures available upon request
Search for excited muons at the future SPPC-based muon-proton colliders
Creators: name: Caliskan, Abdullatif
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We have investigated the production potential of the spin-1/2 excited muons, predicted by the preonic models, at the four SPPC (Super Proton-Proton Collider)-based muon-proton colliders in different center-of-mass energies. For the signal process μp\rightarrowμ^{\star}X\rightarrowμγX, the production cross-section and the decay width values of the excited muons have been calculated. The pseudorapidity and transverse momentum distributions of the final state particles of muons and photons have been obtained to be determine the kinematical cuts best suited for discovery of the excited muons. By applying these cuts we have gotten the discovery, observation and exclusion mass limits of the excited muons for two compositeness scale values. It is shown that the discovery limits on the excited muons in case the compositeness scale equals to 100 TeV are 2.7, 3.9, 3.1 and 6.7 TeV for center-of-mass energies of 10.3, 14.2, 14.6 and 20.2 TeV, respectively.
description: 14 pages, 4 tables, 7 figures
Cosmic Microwave Background Probes Models of Inflation
Creators: name: Davis, R. L.
name: Hodges, H. M.
name: Smoot, G. F.
name: Steinhardt, P. J.
name: Turner, M. S.
Publisher: name: arXiv
Year: 1992
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Inflation creates both scalar (density) and tensor (gravity wave) metric perturbations. We find that the tensor mode contribution to the CMB anisotropy on large-angular scales can only exceed that of the scalar mode in models where the spectrum of perturbations deviates significantly from scale invariance (e.g., extended and power-law inflation models and extreme versions of chaotic inflation). If the tensor mode dominates at large-angular scales, then the value of $ΔT/T$ predicted on $1^\circ$ is less than if the scalar mode dominates, and, for cold dark matter models, $b>1$ can be made consistent with the COBE DMR results.
description: 12 pages, FERMILAB-Pub-92/168-A
An interlaboratory evaluation of the variability in arsenic and lead relative bioavailability when assessed using a mouse bioassay
Creators: name: Li, Hong-Bo
name: Ning, Han
name: Li, Shi-Wei
name: Li, Jie
name: Xue, Rong-Yue
name: Li, Meng-Ya
name: Wang, Meng-Yu
name: Liang, Jia-Hui
name: Juhasz, Albert L.
name: Q., Lena
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Animal bioassays have been developed to estimate oral relative bioavailability (RBA) of metals in soil, dust, or food for accurate health risk assessment. However, the comparability in RBA estimates from different labs remains largely unclear. Using 12 soil and soil-like standard reference materials (SRMs), this study investigated variability in lead (Pb) and arsenic (As) RBA estimates employing a mouse bioassay in 3 labs at Nanjing University, University of Jinan, and Shandong Normal University. Two performances of the bioassay at Nanjing University in 2019 and 2020 showed reproducible Pb and As RBA estimates, but increasing the number of mouse replicates in 2020 produced more precise RBA measurements. Although there were inter-lab variations in diet consumption rate and metal accumulation in mouse liver and kidneys following SRM ingestion due to differences in diet composition, bioassays at 3 labs in 2019 yielded overall similar Pb and As RBA estimates for the 12 SRMs with strong linear correlations between each 2 of the 3 labs for Pb (R2 = 0.95–0.98 and slope = 0.85–1.02) and As RBA outcomes (R2 = 0.46–0.86 and slope = 0.56–0.79). The consistency in RBA estimates was attributed to the relative nature of the final bioavailability outcome, which might overcome the inter-lab variation in diet consumption and metal uptake in mice. These results increased the confidence of use of mouse bioassays in bioavailability studies.
Ion heating and magnetic flux pile-up in a magnetic reconnection experiment with super-Alfvenic plasma inflows
Creators: name: Suttle, L. G.
name: Hare, J. D.
name: Lebedev, S. V.
name: Ciardi, A.
name: Loureiro, N. F.
name: Burdiak, G. C.
name: Chittenden, J. P.
name: Clayson, T.
name: Halliday, J. W. D.
name: Niasse, N.
name: Russell, D.
name: Vidal, F. Suzuki
name: Tubman, E.
name: Lane, T.
name: Ma, J.
name: Robinson, T.
name: Smith, R. A.
name: Stuart, N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: This work presents a magnetic reconnection experiment in which the kinetic, magnetic and thermal properties of the plasma each play an important role in the overall energy balance and structure of the generated reconnection layer. Magnetic reconnection occurs during the interaction of continuous and steady flows of super-Alfvenic, magnetized, aluminum plasma, which collide in a geometry with two-dimensional symmetry, producing a stable and long-lasting reconnection layer. Optical Thomson scattering measurements show that when the layer forms, ions inside the layer are more strongly heated than electrons, reaching temperatures of Ti~ZTe>300 eV - much greater than can be expected from strong shock and viscous heating alone. Later in time, as the plasma density in the layer increases, the electron and ion temperatures are found to equilibrate, and a constant plasma temperature is achieved through a balance of the heating mechanisms and radiative losses of the plasma. Measurements from Faraday rotation polarimetry also indicate the presence of significant magnetic field pile-up occurring at the boundary of the reconnection region, which is consistent with the super-Alfvenic velocity of the inflows.
description: 15 pages, 8 figures, 1 table
Эндоканнабиноиды в растительных ароматических смесях
Creators: name: Фицев Игорь Михайлович
name: Саитгараева Аделя Рашитовна
name: Будников Герман Константинович
Publisher: name: Ученые записки Казанского университета. Серия Естественные науки
Year: 2010
Subjects: СИНТЕТИЧЕСКИЕ ЭНДОКАННАБИНОИДЫ CP-47
497-С8 (2-[(1R
3S)-3-ГИДРОКСИ-ЦИКЛОГЕКСИЛ]-5(2-МЕТИЛНОНАН-2-ИЛ)ФЕНОЛ)
JWH-018 (НАФТАЛИН-1-ИЛ)(1-ПЕНТИЛ-1H-ИНДОЛ-3-ИЛ)МЕТАНОН)
JWH-073 (1-БУТИЛ-1Н-ИНДОЛ-3-ИЛ)(НАФТАЛИН-1-ИЛ)МЕТАНОН
КАННАБИМИМЕТИКИ
РАСТИТЕЛЬНЫЕ АРОМАТИЧЕСКИЕ СМЕСИ
ХРОМАТОМАСС-СПЕКТРОМЕТРИЯ
ИК-СПЕКТРОСКОПИЯ
КРИМИНАЛИСТИЧЕСКАЯ ЭКСПЕРТИЗА И ИДЕНТИФИКАЦИЯ
497-С8
SYNTHETIC ENDOCANNABINOIDS
JWH-018
JWH-073
CANNABIMIMETICS
HERBAL AROMATIC MIXTURES
CHROMATOGRAPHY-MASS SPECTROMETRY
INFRARED SPECTROSCOPY
CRIMINALISTIC EXAMINATION AND IDENTIFICATION

description: В статье представлены итоги комплексного исследования растительных ароматических смесей, содержащих эндоканнабиноиды типа CP-47,497-С8, JWH-018, JWH-073, с применением тонкослойной, газовой хроматографии с масс-селективным и пламенно-ионизационным детекторами, инфракрасной спектроскопии. Показано, что эффективное решение экспертной задачи отнесения их к препаратам, являющимся предметом злоупотреблений, возможно только при использовании комплекса химических и физических методов исследования, обеспечивающих высокую степень надежности.The article discusses the results of complex research of herbal aromatic mixtures containing endocannabinoids like CP-47,497, JWH-018, JWH-073, with application of thin layer chromatography, gas chromatography-mass spectrometry and flame-ionization detector, and infrared spectroscopy. An effective solution of the problem of some cannabinoid mimicking compounds (CP-47,497-С8, JWH-018, and JWH-073) in herbal aromatic mixtures is only achievable with the help of complex chemical and physical methods that could provide a high degree of reliability.
Magic Numbers for Classical Lennard-Jones Cluster Heat Capacities
Creators: name: Frantz, Don D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Heat capacity curves as functions of temperature for classical atomic clusters bound by pairwise Lennard-Jones potentials were calculated for aggregate sizes from 4 to 24 using Monte Carlo methods. J-walking (or jump-walking) was used to overcome convergence difficulties due to quasi-ergodicity in the solid-liquid transition region. The heat capacity curves were found to differ markedly and nonmonotonically as functions of cluster size. Curves for N = 4, 5 and 8 consisted of a smooth, featureless, monotonic increase throughout the transition region, while curves for N = 7 and 15-17 showed a distinct shoulder in this region; the remaining clusters had distinguishable transition heat capacity peaks. The size and location of these peaks exhibited "magic number" behavior, with the most pronounced peaks occurring for magic number sizes of N = 13, 19 and 23. A comparison of the heat capacities with other cluster properties in the solid-liquid transition region that have been reported in the literature indicates partial support for the view that, for some clusters, the solid-liquid transition region is a coexistence region demarcated by relatively sharp, but separate, melting and freezing temperatures; some discrepancies, however, remain unresolved.
description: Journal of Chemical Physics, 51 pages
The targum (1961:May 1 - 1961:May 18)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1961

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.