cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neutrino masses and self-interacting dark matter with mass mixing $Z-Z^\prime$ gauge portal
Creators: name: de la Vega, Leon M. G.
name: Peinado, Eduardo
name: Wudka, Jose
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: New light gauge bosons can affect several low-energy experiments, such as atomic parity violation or colliders. Here, we explore the possibility that a dark sector is charged under a new $U(1)$ gauge symmetry, and the portal to the Standard Model is through a $Z-Z'$ mass mixing. In our approach, breaking the new gauge symmetry is crucial to generate neutrino masses. We investigate the parameter space to reproduce neutrino masses, the correct dark matter relic abundance, and to produce the observed core-like DM distribution in galactic centers.
description: 11 pages, 3 figures
ROLE OF PEPTIDOGLYCAN REMODELING IN OVERCOMING LPS BIOGENESIS DEFECTS IN ESCHERICHIA COLI
Creators: name: GURNANI SERRANO, CARLOS KARAN
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: The three layered Gram-negative bacteria envelope consists of an inner membrane (IM), the periplasm?containing peptidoglycan (PG), and an asymmetric outer membrane (OM) decorated with lipopolysaccharide (LPS) in the outer leaflet. Growth and assembly of cell envelope is orchestrated by action of dedicated protein machineries which span the entire envelope and whose coordinated activity guarantees proper envelope stiffness. Defects in biogenesis in any of these layers compromise the whole cell integrity and lead to cell death. In this thesis we show that Escherichia coli remodels the PG structure by increasing the level of 3-3 crosslinks produced by LD ? Transpeptidases (LDTs), to avoid cell lysis when the LPS transport to the OM is disrupted. E. coli codes for six LDTs (LdtA-F): LdtA, LdtB, and LdtC covalently attach Lpp to PG while LdtD and LdtE introduce 3-3crosslinks. LdtF has no LD-Transpeptidase (LD-Tpase) activity but enhances the enzymatic activity of LdtD and LdtE. Our data outlines a major contribution of LdtD in PG remodelling and suggest that LdtD works in concert with the PG synthase PBP1B, its activator LpoB and the DD-CPase PBP6a to form a dedicated PG repair machine that runs a PG remodeling program to counteract damages to the OM. We also show that the lysis phenotype and morphological defects seen in mutants with an impaired LPS transport and lacking ldtF, are rescued and suppressed, respectively, by the loss of YgeR an uncharacterized lipoprotein predicted to be OM anchored. YgeR belongs to the family of LytM-domain factors which are hydrolases or hydrolase regulators implicated in PG remodeling/turnover. Important PG hydrolases are amidases which promote PG septal splitting and daughter cell separation. Our biochemical data reveal that YgeR is an amidase regulator able to activate AmiA, AmiB and AmiC the three amidases encoded by E. coli. We also show that YgeR binds purified PG and physically interacts with the amidase AmiC. Our biochemical analyses are complemented by in vivo data showing that YgeR preferentially activates AmiC and that it does it through its LytM domain. Altogether, our results point out an unexplored protective role of the 3-3 crosslinks in PG to overcome severe OM biogenesis defects and propose YgeR as a novel amidase activator whose action seems required upon envelope stress.
Blockade of the Corticotropin Releasing Factor Type 1 Receptor Attenuates Elevated Ethanol Drinking Associated With Drinking in the Dark Procedures
Creators: name: Fee, Jon R.
name: Knapp, Darin J.
name: Lowery, Emily G.
name: Thiele, Todd E.
name: Sparrow, Angela M.
name: Sparta, Dennis R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Drinking in the dark (DID) procedures have recently been developed to induce high levels of ethanol drinking in C57BL/6J mice, which result in blood ethanol concentrations (BECs) reaching levels that have measurable affects on physiology and/or behavior. The present experiments determined whether the increased ethanol drinking caused by DID procedures can be attenuated by pretreatment with CP-154,526; a corticotropin releasing factor type-1 (CRF1) receptor antagonist.
Additional file 1 of Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
Creators: name: Kobayashi, Miho
name: Fujiwara, Kashio
name: Takahashi, Kazuki
name: Yoshioka, Yusuke
name: Ochiya, Takahiro
name: Podyma-Inoue, Katarzyna A.
name: Watabe, Tetsuro
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Supplementary Table 1. List of gene-specific primers used for qRT-PCR.
title: The contribution of contrast enhanced bilateral hand magnetic resonance imaging in diagnosis of rheumatoid arthritis and correlation with laboratory parameters
Creators: name: Hursoy, Nur
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Extremities
subject: Musculoskeletal joint
subject: MR
subject: Diagnostic procedure
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease which mainly affects peripheral joints. It is the most prevalent inﬂammatory arthritis. Although effective therapies have been developed, in some patients RA leads to severe...
The Araucaria Project. Accurate stellar parameters and distance to evolved eclipsing binary ASAS J180057-2333.8 in Sagittarius Arm
Creators: name: Suchomska, K.
name: Graczyk, D.
name: Smolec, R.
name: Pietrzyński, G.
name: Gieren, W.
name: Stȩpień, K.
name: Konorski, P.
name: Pilecki, B.
name: Villanova, S.
name: Thompson, I. B.
name: Górski, M.
name: Karczmarek, P.
name: Wielgórski, P.
name: Anderson, R. I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have analyzed the double-lined eclipsing binary system ASAS J180057-2333.8 from the All Sky Automated Survey (ASAS) catalogue . We measure absolute physical and orbital parameters for this system based on archival $V$-band and $I$-band ASAS photometry, as well as on high-resolution spectroscopic data obtained with ESO 3.6m/HARPS and CORALIE spectrographs. The physical and orbital parameters of the system were derived with an accuracy of about 0.5 - 3%. The system is a very rare configuration of two bright well-detached giants of spectral types K1 and K4 and luminosity class II. The radii of the stars are $R_1$ = 52.12 $\pm$ 1.38 and $R_2$ = 67.63 $\pm$ 1.40 R$_\odot$ and their masses are $M_1$ = 4.914 $\pm$ 0.021 and $M_2$ = 4.875$\pm$ 0.021 M$_\odot$ . The exquisite accuracy of 0.5% obtained for the masses of the components is one of the best mass determinations for giants. We derived a precise distance to the system of 2.14 $\pm$ 0.06 kpc (stat.) $\pm$ 0.05 (syst.) which places the star in the Sagittarius-Carina arm. The Galactic rotational velocity of the star is $Θ_s=258 \pm 26$ km s$^{-1}$ assuming $Θ_0=238$ km s$^{-1}$. A comparison with PARSEC isochrones places the system at the early phase of core helium burning with an age of slightly larger than 100 million years. The effect of overshooting on stellar evolutionary tracks was explored using the MESA star code.
description: 10 pages, 6 figures
A shallow layer laboratory model of large-scale atmospheric circulation
Creators: name: Sukhanovskii, Andrei
name: Popova, Elena
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: A new shallow layer laboratory model of global atmosphere circulation is realized. The shallow rotating cylindrical layer of fluid with the localized heater at the bottom periphery and localized cooler in the central part of the upper boundary is considered. The rim heater imitates the equator heating and disc cooler -- the north pole cooling. The rim heater is intentionally shifted from the sidewall to decrease the influence of the no-slip vertical boundaries and provide anticyclonic-cyclonic motion in the upper layer, imitating the formation of large-scale zonal flows (easterlies and westerlies) in the low latitudes. The low-viscous silicon oil is used instead of water to avoid complex effects provided by the formation of a thin film of a surface-active substance on the open surface. The flow transforms from the Hadley-like regime to the baroclinic wave regime through transitional states. The decrease in the thermal Rossby number for the fixed value of Taylor number results in the regularization of the baroclinic waves. The main difference between presented and classical annulus configurations is the absence of the steady waves. All wave regimes, even with regular wave structures, are characterized by strong non-periodic fluctuations. The observed baroclinic wave structures are a combination of temporarily evolving different baroclinic modes. The presented model provides the formation of atmospheric-like flows, characterized by complex temporal behaviour and can serve as an efficient tool for studying different aspects of global atmospheric circulation.
title: Central venous port-catheter system implantation navigated by multispiral chest computer tomography
Creators: name: Cherkashin, Mikhail
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Vascular
subject: Oncology
subject: CT
subject: Catheter venography
subject: Percutaneous
subject: Venous access
subject: Complications
subject: Outcomes analysis
subject: Quality assurance
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Mean safe lifetime for peripheral venous catheter is about 48 hours, for central venous catheter - 14 days [1, 2]. But for long term chemotherapy oncologists need to have adequate venous access for months and sometimes for years. Implantable central...
Community-level cohesion without cooperation
Creators: name: Tikhonov, Mikhail
Publisher: name: arXiv
Year: 2015
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Recent work draws attention to community-community encounters ("coalescence") as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability of a species to survive a coalescence event is best predicted by a community-level "fitness" of its native community rather than the intrinsic performance of the species itself. The model presented here allows formalizing a macroscopic perspective whereby a community harboring organisms at varying abundances becomes equivalent to a single organism expressing genes at different levels. While most natural communities do not satisfy the strict criteria of multicellularity developed by multi-level selection theory, the effective cohesion described here is a generic consequence of division of labor, requires no cooperative interactions, and can be expected to be widespread in microbial ecosystems.
description: 9 pages, 5 figures + supplementary material. Revised and updated
LA SEMPLIFICAZIONE DEI PROCEDIMENTI AMMINISTRATIVI IN MATERIA AMBIENTALE: PROBLEMI E PROSPETTIVE.
Creators: name: CARAPELLUCCI, ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: The thesis addresses the problem of the simplification of administrative procedures in Italian environmental legislation. The historical evolution of the most significant administrative procedures in Environmental Law (including environmental impact assessment, strategic environmental assessment and I.P.P.C.) is analyzed, highlighting the tools and techniques used to simplify them and focusing on the problematic aspects of each. The first chapter analyzes, in general terms, the relationship between the principles of environmental protection - enshrined in International, European and Italian Law - and the discipline of administrative procedures, focusing on the modifications of Law no. 241/1990 in the twenty years since its enactment. The second chapter examines the specific discipline of Environmental impact assessment, Strategic environmental assessment and other environmental assessment procedures, focusing on the attempts to reduce their duration and costs, and to ensure their coordination in italian legislation. The third chapter addresses the same problems with regards to the most relevant authorization procedures in environmental legislation, including those related to the I.P.P.C. (Integrated Pollution Prevention and Control) EU directives.
title: Congenital bronchopulmonary malformation: CT histopathological correlation and step to the national imaging standard
Creators: name: Kočí, Martin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Respiratory system
subject: Thorax
subject: Paediatric
subject: CT
subject: Diagnostic procedure
subject: Audit and standards
subject: Congenital

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Bronchopulmonary malformations (BPMs) refer to a spectrum of pulmonary developmental anomalies, including congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary...
title: Multiparametric MRI (mp-MRI) of the scrotum-A Helpful Tool in differentiating sex-cord stromal tumours from non-stromal malignant testicular neoplasms
Creators: name: Abualruz, Abdulrahman
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system male
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: Observer performance
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Background: Testicular cancer is the most common tumor encountered in young men aged 15–35 years (1-4). Among this age group, about 95% of primary testicular cancers are germ cell tumors (GCT). Sex cord stromal tumors (ST) represent the remaining...
title: Diagnostic performance of MRI in the assessment of invasive placenta previa: can the reader's experience make the difference?
Creators: name: Tavoletta, Alessandra
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Genital / Reproductive system female
subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: MR
subject: Diagnostic procedure
subject: Obstetrics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Invasive placenta is defined when chorionic villi adhere to the myometrium (placenta accreta), invade the myometrium (placenta increta) or penetrate through the uterine serosa with or without extension into the surrounding organs (placenta...
Superstability and Symmetry
Creators: name: VanDieren, Monica M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: This paper continues the study of superstability in abstract elementary classes (AECs) satisfying the amalgamation property. In particular, we consider the definition of $μ$-superstability which is based on the local character characterization of superstability from first order logic. Not only is $μ$-superstability a potential dividing line in the classification theory for AECs, but it is also a tool in proving instances of Shelah's Categoricity Conjecture. In this paper, we introduce a formulation, involving towers, of symmetry over limit models for $μ$-superstable abstract elementary classes. We use this formulation to gain insight into the problem of the uniqueness of limit models for categorical AECs.
description: Accepted for publication by Annals of Pure and Applied Logic
Additional file 2 of Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
Creators: name: Kobayashi, Miho
name: Fujiwara, Kashio
name: Takahashi, Kazuki
name: Yoshioka, Yusuke
name: Ochiya, Takahiro
name: Podyma-Inoue, Katarzyna A.
name: Watabe, Tetsuro
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2: Supplementary Fig. 1. HSC-4 oral cancer cell-derived EVs induce EndoMT in vascular endothelial cells. Supplementary Fig. 2. SAS oral cancer cell-derived EVs induce EndoMT in vascular endothelial cells. Supplementary Fig. 3. SAS oral cancer cell-derived EVs induce vascular destabilization.
PEPTIDE-CONJUGATED MORPHOLINO OLIGOMERS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY
Creators: name: RAMIREZ, AGNESE
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease and the first known genetic cause of infant mortality. It is caused by the homozygous mutations in the Survival Motor Neuron 1 (SMN1) gene, resulting in deficiency of functional SMN protein. The pathologic aspect of SMA is the progressive loss of Motor Neurons (MNs) in the ventral horn of the spinal cord, which causes the loss of muscle function, paralysis and premature death. A first drug for SMA, Nusinersen an antisense oligonucleotide (ASO) has been recently been approved. In fact, one of the most promising strategies in order to increase the SMN protein levels is the use of ASOs to redirect the splicing of the paralogous gene SMN2 to increase the production of the functional SMN protein. ASOs with different chemical structure are currently used in clinical trials, included the ASO with Morpholino (MO) chemistry studied in this work. MO oligomers are particularly suitable for in vivo applications thanks to their optimal safety and efficacy profile. One of the issues related to the administration of ASOs is that they are not able to cross the blood-brain barrier and they must be administered by relatively invasive intrathecal injection to reach the central nervous system (CNS). Therefore, we aimed to improve the efficacy of MO and to develop a non-invasive systemic delivery in an in vivo SMA murine model. First, to increase the efficacy of MO oligomers, we tested, both in vitro and in vivo, four new MO sequences targeting the region involved in the alternative splicing of SMN2 mRNA, called intronic splicing silencer N1 (ISS-N1). Simultaneously, to improve the delivery of MO to affected tissues, we conjugated it to cell-penetrating peptides (CPPs), an approach already used to enhance the cellular and tissue uptake and the pharmacological profile of ASOs, but never explored in SMA. We tested three different CPPs: Tat, R6, and (RXRRBR)2XB, which were linked to our already validated MO sequence [HSMN2Ex7D(-10,-34)]. We administered the conjugates in pre-symptomatic and symptomatic SMA mice to determine their therapeutic efficacy versus unconjugated-MO. We showed that optimization of the target sequence can enhance the splice-correction action of MO oligomers and that the effect of the co-administration of different MO sequences is superior to the delivery of a single sequence. Furthermore, we showed that CPP-MO compounds can up-regulate the SMN protein into the CNS of SMA?7 transgenic murine models as well as their average lifespan and motor performance after local and systemic injection. Our data proved that the CPP-MO conjugates can be a suitable strategy to increase the cellular uptake after an intrathecal administration and to deliver MO oligomers to the CNS after a systemic injection. The presented results provided the basis for the selection of the most efficient CPPs and will set the stage for future clinical trials.
Prediction and Quantification of Individual Athletic Performance
Creators: name: Blythe, Duncan A. J.
name: Király, Franz J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We provide scientific foundations for athletic performance prediction on an individual level, exposing the phenomenology of individual athletic running performance in the form of a low-rank model dominated by an individual power law. We present, evaluate, and compare a selection of methods for prediction of individual running performance, including our own, \emph{local matrix completion} (LMC), which we show to perform best. We also show that many documented phenomena in quantitative sports science, such as the form of scoring tables, the success of existing prediction methods including Riegel's formula, the Purdy points scheme, the power law for world records performances and the broken power law for world record speeds may be explained on the basis of our findings in a unified way.
Few-body hydrodynamic interactions probed by optical trap pulling experiment
Creators: name: Lee, Julian
name: Cotter, Kyle
name: Elsadek, Ibrahim
name: Comstock, Matthew J
name: Pressé, Steve
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: We study the hydrodynamic coupling of neighboring micro-beads placed in a dual optical trap setup allowing us to precisely control the degree of coupling and directly measure time-dependent trajectories of the entrained beads. Average experimental trajectories of a probe bead entrained by the motion of a neighboring scan bead are compared with theoretical computation, illustrating the role of viscous coupling and setting timescales for probe bead relaxation. The findings provide direct experimental corroborations of hydrodynamic coupling at larger, micron spatial scales and millisecond timescales, of relevance to hydrodynamic-assisted colloidal assembly as well as improving the resolution of optical tweezers. We repeat the experiments for three bead setups.
Entropy functions for accelerating black holes
Creators: name: Boido, Andrea
name: Gauntlett, Jerome P.
name: Martelli, Dario
name: Sparks, James
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce an entropy function for supersymmetric accelerating black holes in $AdS_4$, that uplift on general Sasaki-Einstein manifolds $X_7$ to solutions of M-theory. This allows one to compute the black hole entropy without knowing the explicit solutions. A dual holographic microstate counting would follow from computing certain supersymmetric partition functions of Chern-Simons-matter theories compactified on a spindle. We make a general prediction for a class of such partition functions in terms of ``blocks'', with each block being constructed from the partition function on a three-sphere.
description: 6 pages, very minor changes, published version
(100946) Martha Hunter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Classification of focal liver lesions based on histogram analysis of 3D pixel based ADC parametric maps
Creators: name: Drevelegas, Antonios
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Liver
subject: Interventional non-vascular
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: Biopsy
subject: Statistics
subject: Neoplasia
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Diffusion Weighted Imaging (DWI), is an established diagnostic tool for accurate differential diagnosis between benign and malignant liver lesions. Τhe purpose of this study was to examine the feasibility of discriminating focal liver lesions based...
Decreased Immunoreactivity of the Melanocortin Neuropeptide α-Melanocyte-Stimulating Hormone (α-MSH) After Chronic Ethanol Exposure in Sprague-Dawley Rats
Creators: name: Knapp, Darin J.
name: Breese, George R.
name: Navarro, Montserrat
name: Cubero, Inmaculada
name: Thiele, Todd E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin (POMC). Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake. Because ethanol decreases POMC mRNA levels, we determined if exposure to an ethanol-containing diet (ED) would significantly reduce central immunoreactivity of the MC peptide α-MSH in rats. We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist.
Differential Dietary Ethanol Intake and Blood Ethanol Levels in Adolescent and Adult Rats: Effects on Anxiety-Like Behavior and Seizure Thresholds
Creators: name: Breese, George R.
name: Wills, Tiffany A.
name: Overstreet, David H.
name: Knapp, Darin J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Adult rats exhibit increased anxiety-like behavior after exposure to repeated cycles of chronic ethanol and withdrawal. While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined.
Spatially Random Disorder in Unitary Fermion System in $(4-ε)$-Dimensions and Effective Action at Finite Temperature
Creators: name: Gupta, Rajesh Kumar
name: Meenu
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Non-relativistic conformal field theory is significant to understand various aspects of an ultra-cold system. In this paper, we study a non-relativistic system of two-component fermions interacting with a complex boson with Yukawa-like interactions near $d=4$-spatial dimensions in the presence of a quenched disorder. The homogeneous theory flows to an interacting fixed point describing a unitary fermion system. In the presence of the disorder, we find that the system has an interesting phase structure in the space of the coupling constants and exhibits an interacting disorder fixed point in $ε$-expansion. The correlation function obeys Lifshitz scaling behaviour at the disorder fixed point with the anisotropic exponent being $z=2+γ_E$. We also study the disorder system at finite temperature and compute the leading contribution to the 1PI effective action.
description: 25 pages, 6 figures
Differential Modulation of Ethanol-Induced Sedation and Hypnosis by Metabotropic Glutamate Receptor Antagonists in C57BL/6J Mice
Creators: name: Sharko, Amanda C.
name: Hodge, Clyde W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Emerging evidence implicates metabotropic glutamate receptor (mGluR) function in the neurobiological effects of ethanol. The recent development of subtype specific mGluR antagonists has made it possible to examine the roles of specific mGluRs in biochemical and behavioral responses to ethanol. The purpose of the present study was to determine if mGluRs modulate the acute sedative-hypnotic properties of ethanol in mice.
Additional file 3 of Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
Creators: name: Kobayashi, Miho
name: Fujiwara, Kashio
name: Takahashi, Kazuki
name: Yoshioka, Yusuke
name: Ochiya, Takahiro
name: Podyma-Inoue, Katarzyna A.
name: Watabe, Tetsuro
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 3. Original full-length blot images for Fig. 2c.
(100947) James Daniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Periodic impact motions at resonance of a particle bouncing on spheres and cylinders
Creators: name: Sfecci, Andrea
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We investigate the existence of periodic trajectories of a particle, subject to a central force, which can hit a sphere, or a cylinder. We will provide also a Landesman-Lazer type of condition in the case of a nonlinearity satisfying a double resonance condition. Afterwards, we will show how such a result can be adapted to obtain a new result for the impact oscillator at double resonance.
Diffusion Tensor Measures of the Corpus Callosum in Adolescents With Adolescent Onset Alcohol Use Disorders
Creators: name: Gibler, Nicole
name: Nelson, Lauren
name: Hooper, Stephen R.
name: Hege, Steve G.
name: Payne, Martha E.
name: Van Voorhees, Elizabeth
name: MacFall, James
name: De Bellis, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In adults, myelination injury is associated with alcoholism. Maturation of the corpus callosum is prominent during adolescence. We hypothesized that subjects with adolescent-onset alcohol use disorders (AUD; defined as Diagnostic and Statistical Manual of Mental Disorders-IV alcohol dependence or abuse) would have myelination mircostructural differences compared to controls.
title: Diffusion-weighted imaging versus magnetic resonance enterography score in the assessment of Crohn's disease activity: a preliminary study
Creators: name: Martini, Isabella
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: MR
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To establish correlations between Diffusion Weighted Imaging signal (DWI), Magnetic Resonance Enterography score and C-Reactive Protein (CRP) with the aim to evaluate Crohn’s disease activity...
Regulation of Motivation to Self-Administer Ethanol by mGluR5 in Alcohol-Preferring (P) Rats
Creators: name: Faccidomo, Sara
name: Besheer, Joyce
name: Grondin, Julie J.M.
name: Hodge, Clyde W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Emerging evidence indicates that Group I metabotropic glutamate receptors (mGluR1 and mGluR5) differentially regulates ethanol self-administration in several rodent behavioral models. The purpose of this work was to further characterize involvement of Group I mGluRs in the reinforcing effects of ethanol using a progressive ratio schedule of reinforcement.
Relationship Between Medication Adherence and Treatment Outcomes: The COMBINE Study
Creators: name: Zweben, Allen
name: Gorroochurn, Prakash
name: Pettinati, Helen M.
name: Weiss, Roger D.
name: Cox, Christine E.
name: Ciraulo, Domenic
name: Youngblood, Marston
name: Mattson, Margaret E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Within the alcoholism field, there is mounting evidence supporting an important relationship between medication adherence and drinking outcomes. Little is known however, about the complex relationships between medication and treatment variables and drinking outcomes. The present paper reports on the differential impact of medication adherence and treatment factors on drinking outcomes. Data derived from the COMBINE Study was used to investigate the interrelationships between medication adherence, combination treatments and drinking outcomes.
Searching for axion forces with precision precession in storage rings
Creators: name: Agrawal, Prateek
name: Kaplan, David E.
name: Kim, On
name: Rajendran, Surjeet
name: Reig, Mario
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We consider different types of storage rings as precision probes of axion-mediated monopole-dipole forces. We show that current and planned experiments aiming to measure magnetic and electric dipole moments of protons, muons and electrons very precisely may explore new parts of the parameter space beyond existing laboratory bounds and, in some cases, beyond astrophysical constraints. Remarkably, a light axion coupled to muons may explain the FNAL/BNL $(g-2)_μ$ anomaly as an environmental effect -- the coherent axion field generated by the earth nucleons induces an extra contribution to the anomalous precession frequency of the muon explaining the discrepancy with respect to the SM prediction.
description: 12 pages, 3 figures. v2: references added, version accepted in PRD
NICOLA MESARITE, DESCRIZIONE DELLA CHIESA DEI SANTI APOSTOLI A COSTANTINOPOLI. INTRODUZIONE, TRADUZIONE E COMMENTO.
Creators: name: DASKAS, BEATRICE
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: This work presents a reappraisal of the thirteenth-century Description of the Church of the Holy Apostles in Constantinople, by Nikolaos Mesarites. A reviewed translation of the text is offered, along with a new commentary of it, to highlight its features against the historical context to which it belongs.
Posterior consistency and convergence rates for Bayesian inversion with hypoelliptic operators
Creators: name: Kekkonen, Hanne
name: Lassas, Matti
name: Siltanen, Samuli
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: Functional Analysis (math.FA)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: Bayesian approach to inverse problems is studied in the case where the forward map is a linear hypoelliptic pseudodifferential operator and measurement error is additive white Gaussian noise. The measurement model for an unknown Gaussian random variable $U(x,ω)$ is \begin{eqnarray*} M(y,ω) = A(U(x,ω) )+ δ\hspace{.2mm}\mathcal{E}(y,ω), \end{eqnarray*} where $A$ is a finitely many times smoothing linear hypoelliptic operator and $δ>0$ is the noise magnitude. The covariance operator $C_U$ of $U$ is $2r$ times smoothing, self-adjoint, injective and elliptic pseudodifferential operator. If $\mathcal{E}$ was taking values in $L^2$ then in Gaussian case solving the conditional mean (and maximum a posteriori) estimate is linked to solving the minimisation problem \begin{eqnarray*} T_δ(M) = \text{argmin}_{u\in H^r} \big\{\|A u-m\|_{L^2}^2+ δ^2\|C_U^{-1/2}u\|_{L^2}^2 \big\}. \end{eqnarray*} However, Gaussian white noise does not take values in $L^2$ but in $H^{-s}$ where $s>0$ is big enough. A modification of the above approach to solve the inverse problem is presented, covering the case of white Gaussian measurement noise. Furthermore, the convergence of conditional mean estimate to the correct solution as $δ\rightarrow 0$ is proven in appropriate function spaces using microlocal analysis. Also the contraction of the confidence regions is studied.
title: Non-invasive determination of renal cortical, outer and inner medullary blood flow, oxygenation and diffusion in healthy volunteers using ASL, BOLD and DWI MRI
Creators: name: Eckerbom, Per
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Kidney
subject: MR physics
subject: Abdomen
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: Physiological studies
subject: Physics
subject: Experimental investigations
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Due to, among other things, the risks associated with ionizing radiation, contrast media in patients with impaired renal function and the possible risk of cerebral Gadolinium deposition there is a need for non-radiative, non-invasive methods to...
Far- and Near-Field Heat Transfer in Transdimensional Plasmonic Film Systems
Creators: name: Biehs, Svend-Age
name: Bondarev, Igor V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We compare the confinement-induced nonlocal electromagnetic response model to the standard local Drude model routinely used in plasmonics. Both of them are applied to study the heat transfer for transdimensional plasmonic film systems. The former provides greater Woltersdorff length in the far-field and larger film thicknesses at which heat transfer is dominated by surface plasmons, leading to enhanced near-field heat currents. Our results show that the nonlocal response model is capable of making a significant impact on the understanding of the radiative heat transfer in ultrathin films.
Role of Acetaldehyde in Ethanol-Induced Elevation of the Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One in Rats
Creators: name: Boyd, Kevin N.
name: Leslie Morrow, A.
name: O'Buckley, Todd K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Systemic ethanol administration increases neuroactive steroid levels that increase ethanol sensitivity. Acetaldehyde is a biologically active compound that may contribute to behavioral and rewarding effects of ethanol. We investigated the role of acetaldehyde in ethanol–induced elevations of 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP) levels in cerebral cortex.
Generalised helicity formalism, higher moments and the $B \to K_{J_K}(\to K π) \bar{\ell}_1 \ell_2$ angular distributions
Creators: name: Gratrex, James
name: Hopfer, Markus
name: Zwicky, Roman
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We generalise the Jacob-Wick helicity formalism, which applies to sequential decays, to effective field theories of rare decays of the type $B \to K_{J_K}(\to K π) \bar{\ell}_1 \ell_2$. This is achieved by reinterpreting local interaction vertices $\bar b Γ'_{μ_1 ..μ_n} s \bar \ell Γ^{μ_1 ..μ_n} \ell$ as a coherent sum of $1 \to 2$ processes mediated by particles whose spin ranges between zero and $n$. We illustrate the framework by deriving the full angular distributions for $B \to K\bar{\ell}_1 \ell_2$ and $B \to K^*(\to K π) \bar{\ell}_1 \ell_2$ for the complete dimension-six effective Hamiltonian for non-equal lepton masses. Amplitudes and decay rates are expressed in terms of Wigner rotation matrices, leading naturally to the method of moments in various forms. We discuss how higher-spin operators and QED corrections alter the standard angular distribution used throughout the literature, potentially leading to differences between the method of moments and the likelihood fits. We propose to diagnose these effects by assessing higher angular moments. These could be relevant in investigating the nature of the current LHCb anomalies in $R_K = {\cal B}( B \to K μ^+μ^-) /{\cal B}( B \to K e^+e^-)$ as well as angular observables in $B \to K^* μ^+μ^-$.
description: identical to version appeared in PRD. typo in Eq below C.9 corrected, includes Mathematica notebook with angular distribution same as v2
Non-Abelian Floquet Spin Liquids in a Digital Rydberg Simulator
Creators: name: Kalinowski, Marcin
name: Maskara, Nishad
name: Lukin, Mikhail D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Understanding topological matter is an outstanding challenge across several disciplines of physical science. Programmable quantum simulators have emerged as a powerful approach to studying such systems. While quantum spin liquids of paradigmatic toric code type have recently been realized in the laboratory, controlled exploration of topological phases with non-abelian excitations remains an open problem. We introduce and analyze a new approach to simulating topological matter based on periodic driving. Specifically, we describe a model for a so-called Floquet spin liquid, obtained through a periodic sequence of parallel quantum gate operations that effectively simulates the Hamiltonian of the non-abelian spin liquid in Kitaev's honeycomb model. We show that this approach, including the toolbox for preparation, control, and readout of topological states, can be efficiently implemented in state-of-the-art experimental platforms. One specific implementation scheme is based on Rydberg atom arrays and utilizes recently demonstrated coherent qubit transport combined with controlled-phase gate operations. We describe methods for probing the non-abelian excitations, and the associated Majorana zero modes, and simulate possible fusion and braiding experiments. Our analysis demonstrates the potential of programmable quantum simulators for exploring topological phases of matter. Extensions including simulation of Kitaev materials and lattice gauge theories are also discussed.
description: 10+8 pages
The CRF-1 Receptor Antagonist, CP-154,526, Attenuates Stress-Induced Increases in Ethanol Consumption by BALB/cJ Mice
Creators: name: Knapp, Darin J.
name: Breese, George R.
name: Sparrow, Angela M.
name: Thiele, Todd E.
name: Lowery, Emily G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Corticotropin-releasing factor (CRF) signaling modulates neurobiological responses to stress and ethanol, and may modulate observed increases in ethanol consumption following exposure to stressful events. The current experiment was conducted to further characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced increases in ethanol consumption in BALB/cJ and C57BL/6N mice.
(100941) William Cullman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
PROBABILISTIC AND FULL-CHAIN RISK ASSESSMENT OF THE CHEMICAL ACCUMULATION ON HUMAN BODY USING AN INTEGRATED MODELLING TOOL
Creators: name: TANAKA, TAKU
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Mathematical models have been developed to address diverse issues. Especially environmental multimedia models are now well recognized as useful tools for environmental and health risk assessment and management. This dissertation consists of three main pillars: (i) the introduction of the newly developed integrated modelling tool (2-FUN tool) that deals with environmental and health risk assessment, (ii) the investigation of statistical approaches to derive density functions (PDFs) of input parameters of interest, and (iii) the application of the 2-FUN tool for a designed case study. Chapter 1 presents general roles of mathematical models for health and environmental risk assessment of chemicals, the importance to consider parametric uncertainty, and the extensive review on existing modelling methodologies. At the end of the model review, main features of the 2-FUN tool are pointed out as follows: (i) Its capability to conduct a full-chain risk assessment on a common system, which allows linking the simulation of chemical fate in the environmental media, multiple pathways of exposure, and the detailed analysis for multiple effects in different target tissues in human body, (ii) it contains a wide range of methods for sensitivity and uncertainty analyses, and (iii) it can be user-friendly because of its effective graphical simulation interface and its flexibility, which facilitates users to design scenarios for target regions and arrange the tool on their own ways. The conceptual and theoretical aspects of the 2-FUN tool are summarized in Chapter 2. The focus of Chapter 3 is set at the detailed presentation of two advanced statistical approaches to derive probabilistic density function (PDF) for the two parameters used in the freshwater compartment of the 2-FUN tool: the settling velocity of particles that is a driving factor influencing the transfer of particles at the water-sediment interface in fresh-water system, and the fish bioconcentration factor (BCF) for metal that represents the accumulation of a given chemical in organisms arising by water uptake. Finally, Chapter 4 depicts how the 2-FUN tool can be applied based on a designed case study and shows the feasibility of the integrated modelling approach to couple an environmental multimedia and a PBPK models, considering multi-exposure pathways, and thus the potential applicability of the 2-FUN tool for health risk assessment.