cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A study on exponentiated Gompertz distribution under Bayesian discipline using informative priors
Creators: name: Aslam, M
name: Afzaal, M
name: Bhatti, Ishaq
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4905
subject: Statistics
subject: FOS: Mathematics

description: The exponentiated Gompertz (EGZ) distribution has been recently used in almost all areas of human endeavours, starting from modelling lifetime data to cancer treatment. Various applications and properties of the EGZ distribution are provided by Anis and De (2020). This paper explores the important properties of the EGZ distribution under Bayesian discipline using two informative priors: The Gamma Prior (GP) and the Inverse Levy Prior (ILP). This is done in the framework of five selected loss functions. The findings show that the two best loss functions are the Weighted Balance Loss Function (WBLF) and the Quadratic Loss Function (QLF). The usefulness of the model is illustrated by the use of reallife data in relation to simulated data. The empirical results of the comparison are presented through a graphical illustration of the posterior distributions.
On an Extension of a Static Ball Solution
Creators: name: Baranov, Alexandre M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A new exact static interior solution of the Einstein equations is obtained for a gravitating ball filled with a Pascal perfect fluid . The solution is an extension of the well-known interior solution with a parabolic distribution of mass density and describes more compact astrophysical objects such as neutron and hyperon stars. It is shown that a behaviour of the new mass density distribution near the stellar centre can be described as a cusp catastrophe.
description: 2 pages, Proceedings of the 12th Russian Gravitational Conference, Kazan, 20-36 June 2005
title: Potential for using paper mill fly-ash as an alternate liming material  and mobility and leachability of heavy metals in fly-ash and biochar  amended agricultural soil in Western Newfoundland
Creators: name: Maheswaran, Gnanakaran
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: Most agricultural soils in Western Newfoundland are acidic and need lime to raise the soil pH to
 be productive. Corner Brook Pulp and Paper Ltd produces a substantial amount of fly-ash which
 is being disposed at a local landfill. This study was conducted to assess the potential for using fly-ash as a liming material for an agricultural soil (pH:5.5) in Western Newfoundland with the
 addition of biochar for heavy metal stabilization. Heavy metal concentration in the soil and fly-ash were analysed and compared with soil and compost guidelines. Lab scale leaching and pot
 experiments were conducted to assess the leaching and bioavailability of heavy metals in fly-ash
 amended soil with different biochar rates. As per quality guidelines, only part of the lime
 requirement can be substituted by fly-ash. Biochar increased the soil pH and biomass production.
 Total heavy metal leached from biochar treated soils were low and unlikely to cause groundwater
 contamination. In general biochar reduces the leachability and the bio availability of heavy metals.
 Application of biochar could provide a sustainable solution for the heavy metal stabilization of
 fly-ash treated soil.
Feature-based registration of preoperative CT to intraoperative 3-D ultrasound in laparoscopic partial nephrectomy using a priori CT segmentation
Creators: name: Bartlett, John George
Publisher: name: University of British Columbia
Year: 2011

description: Robotic laparoscopic partial nephrectomy is a state-of-the-art procedure for the excision of renal tumours. The challenges of this surgery along with the stereoscopic interface to the surgeon make it an ideal candidate for image guidance. We propose bringing pre-operative computed tomography data to the patient's coordinate system using three-dimensional intraoperative back ultrasound. Since computed tomography and ultrasound images represent like anatomical information quite differently, we perform a manual segmentation of the computed tomography before the operation and a semi-automatic segmentation of the ultrasound intra-operatively. The segmentation of the kidney boundary facilitates a feature-based registration strategy. Semi-automatic segmentation of kidney ultrasound images is difficult because the edges with large gradient values do not correspond to the capsule boundary seen in computed tomography. The desired edges are actually quite faint in ultrasound and poorly detected by common edge methods such as the Canny approach. After trying a number of approaches, the best results were obtained using a novel interacting multiple-model probabilistic data association filter to select edges from ultrasound images that were filtered for phase congruency. The manual segmentation of the prior is used to guide edge detection in ultrasound. Experiments on seven pre-operative patient datasets and one intra-operative patient dataset resulted in a mean volume error ratio of 0.80 +/- 0.13 from after registration to before registration. These results came after the implementation and evaluation of numerous other approaches, including radial edge filters, the covariance matrix adaptation evolution strategy, and a deformable approach using geodesic active contours. The main contribution of this work is a method for the registration of the pre-operative planning data from computerized tomography to the intraoperative ultrasound. For clinical use, this method requires some form of calibration with the laparoscopic camera and integration with surgical visualization tools. Through integration with emerging technologies, the approach presented here can one day augment the surgical field-of-view and guide the surgeon around important anatomical structures to the tissue that must be excised.
Escape of the Genie
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1983
Subjects: Medicine
Science
History

description: Use of cannabis (hashish) in Egypt as an intoxicant was first reported in the 11th century, more than 500 years after the death of the prophet Mohamed (A.D. 615), when Islam had already reached the apogee of its power. During succeeding centuries consumption of this drug had become ingrained among the people in spite of repeated attempts by the rulers of the country to curtail its spread.
The Star Formation Rate Function for Redshift z~4-7 Galaxies: Evidence for a Uniform Build-Up of Star-Forming Galaxies During the First 3 Gyr of Cosmic Time
Creators: name: Smit, Renske
name: Bouwens, Rychard J.
name: Franx, Marijn
name: Illingworth, Garth D.
name: Labbé, Ivo
name: Oesch, Pacal A.
name: van Dokkum, Pieter G.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We combine recent estimates of dust extinction at z~4-7 with UV luminosity function (LF) determinations to derive star formation rate (SFR) functions at z~4, 5, 6 and 7. SFR functions provide a more physical description of galaxy build-up at high redshift and allow for direct comparisons to SFRs at lower redshifts determined by a variety of techniques. Our SFR functions are derived from well-established z~4-7 UV LFs, UV-continuum slope trends with redshift and luminosity, and IRX-beta relations. They are well-described by Schechter relations. We extend the comparison baseline for SFR functions to z~2 by considering recent determinations of the Hα and mid-IR luminosity functions. The low-end slopes of the SFR functions are flatter than for the UV LFs, Δα\sim+0.13, and show no clear evolution with cosmic time (z~0-7). In addition, we find that the characteristic value SFR* from the Schechter fit to SFR function exhibits consistent, and substantial, linear growth as a function of redshift from ~5 M_sun/yr at z~8, 650 Myr after the Big Bang, to ~100 M_sun/yr at z~2, ~2.5 Gyr later. Recent results at z~10, close to the onset of galaxy formation, are consistent with this trend. The uniformity of this evolution is even greater than seen in the UV LF over the redshift range z~2-8, providing validation for our dust corrections. These results provide strong evidence that galaxies build up uniformly over the first 3 Gyr of cosmic time.
description: Added an appendix, 1 figure and 3 tables: 9 pages, 5 figures, 4 tables, ApJ, in press
Additional file 1 of Pulmonary sclerosing pneumocytoma and mortality risk
Creators: name: Kim, So Jeong
name: Kang, Hye-Rin
name: Lee, Choon Geun
name: Choi, Seung Ho
name: Kim, Yeon Wook
name: Lee, Hyun Woo
name: Lee, Chang-Hoon
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1: Table S1. Characteristics of patients with pulmonary sclerosing pneumocytoma and age-, sex-, and smoking status-matched controls. Table S2. Review of pulmonary sclerosing pneumocytoma cases with lymph node metastases, distant metastases, recurrence, and deaths published worldwide.
The Distance, Inclination, and Spin of the Black Hole Microquasar H1743-322
Creators: name: Steiner, James F.
name: McClintock, Jeffrey E.
name: Reid, Mark J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: During its 2003 outburst, the black-hole X-ray transient H1743-322 produced two-sided radio and X-ray jets. Applying a simple and symmetric kinematic model to the trajectories of these jets, we determine the source distance, 8.5 \pm 0.8 kpc, and the inclination angle of the jets, 75 \pm 3 degrees. Using these values, we estimate the spin of the black hole by fitting its RXTE spectra, obtained during the 2003 outburst, to a standard relativistic accretion-disk model. For its spin, we find a*=0.2 \pm 0.3 (68% limits); -0.3 < a* < 0.7 at 90% confidence. We rule strongly against an extreme value of spin: a* < 0.92 at 99.7% confidence. H1743-322 is the third known microquasar (after A0620-00 and XTE J1550-564) that displays large-scale ballistic jets and has a moderate value of spin. Our result, which depends on an empirical distribution of black hole masses, takes into account all known sources of measurement error.
description: Submitted to ApJ Letters. 12 manuscript pages and 4 figures; spin results have been updated
Are people more likely to vape or smoke inside? A cross-sectional population survey of adults in England
Creators: name: Shahab, Lion
name: Tattan-Birch, Harry
name: Jackson, Sarah
name: Brown, Jamie
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Public Health
subject: Health Psychology
subject: Psychology
subject: FOS: Psychology
subject: Medicine and Health Sciences
subject: Epidemiology

description: Using data from the Health Survey for England 2019, we aim to estimate, among people who exclusively smoke, exclusively vape, and dual use, the percentage that report having recently used their nicotine products inside (anywhere inside, inside the home, inside the car, and/or inside other places). In exclusive users, we will also examine how the prevalence of inside vaping and smoking varies by age, sex, housing tenure, social grade, presence of a child or adult in the home, smoking and vaping history, and nicotine dependence.
Maximizing research value and use through enhanced data documentation
Creators: name: Goldman, Julie
name: Obrycki, John
Publisher: name: Zenodo
Year: 2020
Subjects: Clinical Research
Epidemiology
Data Management
FAIR Data Principles

description: This poster highlights how FAIR Principles were applied to a study population and provides resources for incorporating best practices into your studies. Recent efforts, including from the National Institutes of Health (NIH) Final Policy for Data Management and Sharing (NOT-OD-21-013), highlight new data management requirements. A key component is applying FAIR Principles. We applied these principles to an NIH-funded study (R01ES027825, 2018-present, PI: Dr. Maitreyi Mazumdar). This study in Bangladesh evaluates how arsenic exposure affects respiratory health.
description: Funding: NIEHS R01ES027825-S1 supported this work. Content does not necessarily represent the official views of NIH.
description: {"references": ["Wilkinson, M., Dumontier, M., Aalbersberg, I. et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 3, 160018 (2016). https://doi.org/10.1038/sdata.2016.18"]}
Characterizing Transition Temperature Gas in the Galactic Corona
Creators: name: Wakker, Bart P.
name: Savage, Blair D.
name: Fox, Andrew J.
name: Benjamin, Robert A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a study of the properties of the transition temperature (T~10^5 K) gas in the Milky Way corona, based on measurements of OVI, NV, CIV, SiIV and FeIII absorption lines seen in the far ultraviolet spectra of 58 sightlines to extragalactic targets, obtained with Far-Ultraviolet Spectroscopic Explorer (FUSE) and Space Telescope Imaging Spectrograph. In many sightlines the Galactic absorption profiles show multiple components, which are analyzed separately. We find that the highly-ionized atoms are distributed irregularly in a layer with a scaleheight of about 3 kpc, which rotates along with the gas in the disk, without an obvious gradient in the rotation velocity away from the Galactic plane. Within this layer the gas has randomly oriented velocities with a dispersion of 40-60 km/s. On average the integrated column densities are log N(OVI)=14.3, log N(NV)=13.5, log N(CIV)=14.2, log N(SiIV)=13.6 and log N(FeIII)=14.2, with a dispersion of just 0.2 dex in each case. In sightlines around the Galactic Center and Galactic North Pole all column densities are enhanced by a factor ~2, while at intermediate latitudes in the southern sky there is a deficit in N(OVI) of about a factor 2, but no deficit for the other ions. We compare the column densities and ionic ratios to a series of theoretical predictions: collisional ionization equilibrium, shock ionization, conductive interfaces, turbulent mixing, thick disk supernovae, static non-equilibrium ionization (NIE) radiative cooling and an NIE radiative cooling model in which the gas flows through the cooling zone. None of these models can fully reproduce the data, but it is clear that non-equilibrium ionization radiative cooling is important in generating the transition temperature gas.
description: 99 pages, 11 figures, with appendix on Cooling Flow model; only a sample of 5 subfigures of figure 2 included - full set of 69 available through ApJ
Emerging La Niña conditions in the equatorial Pacific : notes for the health community
Creators: name: Omumbo, Judith A.
name: Braman, Lisette M.
name: Barnston, Anthony G.
Publisher: name: Columbia University
Year: 2010
Subjects: Environmental sciences
Public health

description: This report provides information to assist monitoring of vulnerable communities and provide time sensitive information for interventions to reduce negative health impacts. It is prudent for health decision makers to follow the situation for any developments and monitor climate/weather forecasts as part of an early warning-early action approach. Resources and recommendations for monitoring the situation are presented.
Fractional and noncommutative spacetimes
Creators: name: Arzano, Michele
name: Calcagni, Gianluca
name: Oriti, Daniele
name: Scalisi, Marco
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We establish a mapping between fractional and noncommutative spacetimes in configuration space. Depending on the scale at which the relation is considered, there arise two possibilities. For a fractional spacetime with log-oscillatory measure, the effective measure near the fundamental scale determining the log-period coincides with the non-rotation-invariant but cyclicity-preserving measure of κ-Minkowski. At scales larger than the log-period, the fractional measure is averaged and becomes a power-law with real exponent. This can be also regarded as the cyclicity-inducing measure in a noncommutative spacetime defined by a certain nonlinear algebra of the coordinates, which interpolates between κ-Minkowski and canonical spacetime. These results are based upon a braiding formula valid for any nonlinear algebra which can be mapped onto the Heisenberg algebra.
description: 15 pages. v2: typos corrected
Large-sample study of the kernel density estimators under multiplicative censoring
Creators: name: Asgharian, Masoud
name: Carone, Marco
name: Fakoor, Vahid
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: The multiplicative censoring model introduced in Vardi [Biometrika 76 (1989) 751--761] is an incomplete data problem whereby two independent samples from the lifetime distribution $G$, $\mathcal{X}_m=(X_1,...,X_m)$ and $\mathcal{Z}_n=(Z_1,...,Z_n)$, are observed subject to a form of coarsening. Specifically, sample $\mathcal{X}_m$ is fully observed while $\mathcal{Y}_n=(Y_1,...,Y_n)$ is observed instead of $\mathcal{Z}_n$, where $Y_i=U_iZ_i$ and $(U_1,...,U_n)$ is an independent sample from the standard uniform distribution. Vardi [Biometrika 76 (1989) 751--761] showed that this model unifies several important statistical problems, such as the deconvolution of an exponential random variable, estimation under a decreasing density constraint and an estimation problem in renewal processes. In this paper, we establish the large-sample properties of kernel density estimators under the multiplicative censoring model. We first construct a strong approximation for the process $\sqrt{k}(\hat{G}-G)$, where $\hat{G}$ is a solution of the nonparametric score equation based on $(\mathcal{X}_m,\mathcal{Y}_n)$, and $k=m+n$ is the total sample size. Using this strong approximation and a result on the global modulus of continuity, we establish conditions for the strong uniform consistency of kernel density estimators. We also make use of this strong approximation to study the weak convergence and integrated squared error properties of these estimators. We conclude by extending our results to the setting of length-biased sampling.
description: Published in at http://dx.doi.org/10.1214/11-AOS954 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
title: An exploration of the relationships between students’ listening skills, self-rated academic listening, and their metacognitive awareness
Creators: name: Deb, Joyshree
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: This empirical study investigated international students’ challenges in listening to academic lectures, and their use of metacognitive listening strategies to overcome their problems. The participants were 46 international students at Memorial University of Newfoundland who were enrolled in various levels of different academic programs. The data were collected using the following instruments: an IELTS listening test, demographic questions, the self-rated academic listening questionnaire (ALSA), the metacognitive awareness listening questionnaire (MALQ), and two open-ended questions. The results were analyzed using descriptive statistics, one-way ANOVA, Pearson-product moment correlation coefficients, and linear regressions to measure the relationship between listening skills, self-rated academic listening, and the use of metacognitive strategies while performing academic listening. The results of the study suggest that (1) there is a negative relationship between students’ listening performance and their use of metacognitive strategies, and (2) there is a positive relationship between students’ listening performance and self-rated academic listening skills. ANOVA results show that PhD students perform much lower in listening compared to undergraduate and master’s students. The results of the open-ended questions revealed the major reasons behind listening challenges encountered by the international students and their suggestions on the way of overcoming these challenges. The findings of this study are informative for teachers to understand international students’ listening difficulties and help them improve their pedagogical methods. The study may also be useful for researchers who are interested to work in the field of second language listening.
Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: a controlled before-and-after trial
Creators: name: Molotkova, Evgeniya
name: Kolsky, Pete
name: Zuin, Valentina
name: Stewart, Jill
name: Sumner, Trent
name: Zambrana, Winnie
name: Knee, Jackie
name: Braga, Judite Monteiro
name: MacDougall, Amy
name: Schmidt, Wolf Peter
name: Holcomb, David A
name: Brown, Joe
name: Cumming, Oliver
name: Casmo, Veronica
name: Bush, Farran
name: Russo, Celina
name: Nalá, Rasul
name: Capone, Drew
name: Anderson, Claire
name: Adriano, Zaida
Publisher: name: eLife
Year: 2021

description:
We conducted a controlled before-and-after trial to evaluate the impact of an onsite urban sanitation intervention on the prevalence of enteric infection, soil transmitted helminth re-infection, and diarrhea among children in Maputo, Mozambique. A non-governmental organization replaced existing poor-quality latrines with pour-flush toilets with septic tanks serving household clusters. We enrolled children aged 1-48 months at baseline and measured outcomes before and 12 and 24 months after the intervention, with concurrent measurement among children in a comparable control arm. Despite nearly exclusive use, we found no evidence that intervention affected the prevalence of any measured outcome after 12 or 24 months of exposure. Among children born into study sites after intervention, we observed a reduced prevalence of Trichuris and Shigella infection relative to the same age group at baseline (<2 years old). Protection from birth may be important to reduce exposure to and infection with enteric pathogens in this setting.
Atenção ao Câncer de Colo de Útero no Estado do Rio de Janeiro: Qualidade dos Exames de Citopatológicos
Creators: name: Carvalho, Beatrice
name: Souza, Carmen Andrea Carneiro da S.
name: Souza, Emanuel Felix de
name: Vassoler, Rita de Cassia
name: Pinto, Vanessa de Oliveira
name: Souza, Ana Sara Semeão de
name: Franco, Thais de Andrade Vidaurre
name: Kuschnir, Rosana Chigres
Publisher: name: Zenodo
Year: 2024

description: Este sumário executivo é produto do Estágio de Prática Profissional do Mestrado Profissional em Saúde Coletiva do Instituto de Medicina Social da Universidade do Estado do Rio de Janeiro em parceria com a Secretaria de Estado de Saúde do Rio de Janeiro.

O que se espera com este documento é fornecer subsídios técnicos para a gestão estratégica do SUS no ERJ, auxiliando na priorização e monitoramento das ações de qualidade do rastreamento do câncer de colo do útero no Estado, otimizando recursos e reduzindo a carga de mortalidade da doença na população.
Consensus clustering in complex networks
Creators: name: Lancichinetti, Andrea
name: Fortunato, Santo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The community structure of complex networks reveals both their organization and hidden relationships among their constituents. Most community detection methods currently available are not deterministic, and their results typically depend on the specific random seeds, initial conditions and tie-break rules adopted for their execution. Consensus clustering is used in data analysis to generate stable results out of a set of partitions delivered by stochastic methods. Here we show that consensus clustering can be combined with any existing method in a self-consistent way, enhancing considerably both the stability and the accuracy of the resulting partitions. This framework is also particularly suitable to monitor the evolution of community structure in temporal networks. An application of consensus clustering to a large citation network of physics papers demonstrates its capability to keep track of the birth, death and diversification of topics.
description: 11 pages, 12 figures. Published in Scientific Reports
Gaussian Process Cosmography
Creators: name: Shafieloo, Arman
name: Kim, Alex G.
name: Linder, Eric V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Gaussian processes provide a method for extracting cosmological information from observations without assuming a cosmological model. We carry out cosmography -- mapping the time evolution of the cosmic expansion -- in a model-independent manner using kinematic variables and a geometric probe of cosmology. Using the state of the art supernova distance data from the Union2.1 compilation, we constrain, without any assumptions about dark energy parametrization or matter density, the Hubble parameter and deceleration parameter as a function of redshift. Extraction of these relations is tested successfully against models with features on various coherence scales, subject to certain statistical cautions.
description: 9 pages, 5 figures; v2 minor changes to match PRD version
Kondo Force in Shuttling Devices: Dynamical Probe for a Kondo Cloud
Creators: name: Kiselev, M. N.
name: Kikoin, K. A.
name: Gorelik, L. Y.
name: Shekhter, R. I.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider electromechanical properties of a single-electronic device consisting of movable quantum dot attached to a vibrating cantilever, forming a tunnel contact with a non-movable source electrode. We show that the resonance Kondo tunneling of electrons amplify exponentially the strength of nanoelectromechanical (NEM) coupling in such device and makes the latter to be insensitive to mesoscopic fluctuations of electronic levels in a nano-dot. It is also shown that the study of Kondo-NEM phenomenon provides an additional (as compared with a standard conductance measurements in a non-mechanical device) information on retardation effects in formation of many-particle cloud accompanied the Kondo tunneling. A possibility for superhigh tunability of mechanical dissipation as well as supersensitive detection of mechanical displacement is demonstrated.
description: 4.5 pages, 2 figures
Deliverable D2.3 – Exploitation and Sustainability Plan
Creators: name: Walker, Perpetua Socorro
name: Fenter, Frederick
Publisher: name: Zenodo
Year: 2019
Subjects: OpenUP exploitation sustainability plan

description: This document is the first result of process designed to last for the whole duration of the project. The

planned outcome was a detailed plan to exploit and sustain OpenUP’s achievements after the end of

the project.

Section two of this document presents a SWOT (Strengths, Weaknesses, Opportunities and Threats)

analysis of Open Science and four of its key components: Open Access, Open Peer Review, Open

Dissemination and Open Metric. The analysis identifies areas of strengths and opportunities, as well as

areas where further development and attention is required.

The third section describes a plan to further develop this initial analysis identifying key exploitable

areas and target stakeholders, as well as targets, indicators and milestones and guidelines for future

exploitation.
Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles
Creators: name: Feng, Xue
name: Chen, Yuting
name: Li, Luya
name: Zhang, Yuqian
name: Zhang, Lantong
name: Zhang, Zhiqing
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology

description: Amentoflavone (AMF) is a kind of biflavonoids existing in Ginkgo biloba leaves. It has many biological activities, such as antioxidant, anti-inflammatory, anti-bacterial, antiviral, hypoglycemic, anti-tumor and inducing apoptosis. However, its solubility and bioavailability are poor and there are a few studies on it in vivo. In this study, to improve its solubility and bioavailability, the nanomicelles were prepared with TPGS and soluplus as carriers for the first time. The particle size, Zeta potential, encapsulation efficiency, drug loading, stability, cytotoxicity, cellular uptake, and metabolites in rats were studied. Cytotoxicity, cellular uptake, and metabolites in rats of AMF-loaded TPGS/soluplus mixed micelles were compared with those of AMF. As a result, AMF-loaded TPGS/soluplus mixed micelles with a particle size of 67.33 ± 2.01 nm and Zeta potential of −0.84133 ± 0.041405 mV were successfully prepared. The encapsulation efficiency and drug loading of the mixed nanomicelles were 99.18 ± 0.76% and 2.47 ± 0.01%, respectively. The physical and chemical properties of the mixed micelles were stable within 60 d, and the cytotoxicity of the mixed micelles was much greater than that of AMF monomers. Thirty-four kinds of metabolites of AMF were identified in rats. The metabolites were mainly distributed in rat feces. No metabolites were detected in bile and plasma. 14 kinds of metabolites of the mixed micelles in rats were detected, including 11 in feces, 6 in urine, and 3 in plasma, which indicated that the bioavailability of AMF has been improved. And the toxicity to cancer cells was enhanced, which laid a foundation for the development of new drugs.
A Capabilities Approach to Successful Societies
Creators: name: Hall, Peter A.
Publisher: name: Columbia University
Year: 2010
Subjects: Political science--Authorship
Europeans

description: What creates a successful society? There is no simple answer to this question because decisions about the criteria by which success should be measured inevitably depend on normative judgments that are contestable, and real-world conditions often entail concessions on some dimensions of success to secure improvements in others. For these reasons, even the most sophisticated e"orts to address this problem, such as Amartya Sen’s impressive theory of development as freedom, can be frustratingly indeterminate. As Michèle Lamont and I argue in Successful Societies: How Institutions and Culture A!ect Health (Cambridge University Press 2009), however, this question is too important to ignore. Even when the answers are necessarily incomplete, social scientists should be asking such questions. Although there is a natural preference for more tractable subjects, the watchword of social science should not be ‘convenience’. We need to advance our understanding not only of how societies work but of how they can work better.
title: Characterization of Vps13 in Drosophila melanogaster
Creators: name: Kasravi, Kiana
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: Parkinson Disease (PD), the most common movement disorder, is a neurodegenerative disease that affects about 1% of the human population over the age of 65 years, and its prevalence increases with age. PD is clinically characterized by resting tremor, rigidity and bradykinesia as a result of the loss of dopaminergic neurons in the substantia nigra pars compacta in the mid-brain. Mitochondria play a significant role in PD. The PD candidate gene VPS13C was identified in human using whole-exome sequencing (WES). The VPS13C protein is involved in intracellular trafficking, especially lipid transportation, between the endoplasmic reticulum (ER) and other organelles, such as the late endosome/lysosome, as well as in the mitophagy pathway. I have successfully characterized the homologue of the human VPS13C gene in flies, Vps13. As a result, I have successfully modelled aspects of PD in Drosophila melanogaster. I found that inhibition of Vps13 improves the longevity and locomotor ability, while overexpression of Vps13 mostly reduced both the survival and locomotor abilities of flies. Furthermore, I have demonstrated that overexpression of Vps13 significantly influences neurodevelopment when expressed in the developing Drosophila melanogaster eye. Our final set of experiments focused upon the consequences of the inhibition and overexpression of Vps13 when expressed with the co-inhibition of parkin, a well-known PD gene. These co-expressions can give valuable insights into the genetic and/or functional connections between the two genes or their protein products. These findings suggest that the inhibition of parkin may improve the effects of Vps13 overexpression.
The First 1 1/2 Years of TOTEM Roman Pot Operation at LHC
Creators: name: Deile, M.
name: Antchev, G. H.
name: Appleby, R. B.
name: Assmann, R. W.
name: Atanassov, I.
name: Avati, V.
name: Baechler, J.
name: Bruce, R.
name: Dupont, M.
name: Eggert, K.
name: Farnham, B.
name: Kaspar, J.
name: Rodriguez, F. Lucas
name: Morant, J.
name: Niewiadomski, H.
name: Pons, X.
name: Radermacher, E.
name: Ravat, S.
name: Ravotti, F.
name: Redaelli, S.
name: Ruggiero, G.
name: Sabba, H.
name: Sapinski, M.
name: Snoeys, W.
name: Valentino, G.
name: Wollmann, D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Since the LHC running season 2010, the TOTEM Roman Pots (RPs) are fully operational and serve for collecting elastic and diffractive proton-proton scattering data. Like for other moveable devices approaching the high intensity LHC beams, a reliable and precise control of the RP position is critical to machine protection. After a review of the RP movement control and position interlock system, the crucial task of alignment will be discussed.
description: 3 pages, 6 figures; 2nd International Particle Accelerator Conference (IPAC 2011), San Sebastian, Spain; contribution MOPO011
The requirement for competent antigen presenting dendritic cells and poised T cells for immune responses
Creators: name: Omilusik, Kyla Dione
Publisher: name: University of British Columbia
Year: 2011

description: Immune responses are initiated by dendritic cells (DCs) that cross present exogenous antigen to naïve T cells. DC cross presentation is essential for generating primary immune responses, yet the mechanistic details remain undefined. Using a CD74⁻/⁻ mouse model, a CD74-MHC I association was shown to mediate trafficking of MHC I from the endoplasmic reticulum to endolysosomal compartments for antigenic loading. These studies describe a novel CD74-mediated cross presentation pathway in DCs that plays a major role in the generation of cytolytic T lymphocyte (CTL) responses against viral and cell-associated antigens. Viruses such as Human Immunodeficiency Virus (HIV) have evolved mechanisms to interfere with immune activation allowing persistence in the host. HIV can infect DCs so the HIV virulence factor, Nef, which interacts with MHC I, has the potential to interfere with MHC I trafficking in the cross presentation pathway. Using a Nef-expressing DC line, Nef was shown to downregulate surface MHC I by inhibiting Golgi-to-surface transport of newly synthesized MHC I and by increasing the recycling of surface MHC I. Coordinately, Nef was shown to inhibit both direct and cross presentation of viral and soluble antigen. Similarly, in a Nef transgenic mouse, Nef was shown to inhibit CTL responses to bacterial and viral infections. This unique immunosubversion mechanism likely contributes to immunodeficiency associated with Acquired Immunodeficiency Syndrome. Peripheral pools of naïve T cells capable of responding to DC stimulus are maintained through homeostatic cues including TCR signalling. Key to this is the second messenger calcium (Ca²⁺); however, the identity of the components regulating intracellular Ca²⁺ concentrations is unclear. Through examination of a knock-out mouse model, the Ca²⁺ channel, CaV1.4, was shown to play a cell-intrinsic role in naïve T cell development and survival. CaV1.4 is critical for regulation of intracellular Ca²⁺ stores and for TCR-induced increases in cytosolic Ca²⁺, which impacts Ras/ERK and NFAT activation. The CaV1.4 deficiency causes a loss of naïve T cells and results in immunodeficiency. These studies reveal a critical function for CaV1.4 in naïve T cell homeostasis. Collectively, this thesis demonstrates the importance of cross presenting DCs and maintenance of T cells for functional immunity.
Random Transverse Field Ising Model in dimension $d=2,3$ : Infinite Disorder scaling via a non-linear transfer approach
Creators: name: Monthus, Cecile
name: Garel, Thomas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The 'Cavity-Mean-Field' approximation developed for the Random Transverse Field Ising Model on the Cayley tree [L. Ioffe and M. Mézard, PRL 105, 037001 (2010)] has been found to reproduce the known exact result for the surface magnetization in $d=1$ [O. Dimitrova and M. Mézard, J. Stat. Mech. (2011) P01020]. In the present paper, we propose to extend these ideas in finite dimensions $d>1$ via a non-linear transfer approach for the surface magnetization. In the disordered phase, the linearization of the transfer equations correspond to the transfer matrix for a Directed Polymer in a random medium of transverse dimension $D=d-1$, in agreement with the leading order perturbative scaling analysis [C. Monthus and T. Garel, arxiv:1110.3145]. We present numerical results of the non-linear transfer approach in dimensions $d=2$ and $d=3$. In both cases, we find that the critical point is governed by Infinite Disorder scaling. In particular exactly at criticality, the one-point surface magnetization scales as $\ln m_L^{surf} \simeq - L^{ω_c} v$, where $ω_c(d)$ coincides with the droplet exponent $ω_{DP}(D=d-1)$ of the corresponding Directed Polymer model, with $ω_c(d=2)=1/3$ and $ω_c(d=3) \simeq 0.24$. The distribution $P(v)$ of the positive random variable $v$ of order O(1) presents a power-law singularity near the origin $P(v) \propto v^a$ with $a(d=2,3)>0$ so that all moments of the surface magnetization are governed by the same power-law decay $\bar{(m_L^{surf})^k} \propto L^{- x_S}$ with $x_S=ω_c (1+a)$ independently of the order $k$.
description: v2=revised version (12 pages, 15 figures)
Supplement for No Long-Term Effects of Antenatal Synthetic Glucocorticoid Exposure on Epigenetic Regulation of Stress-Related Genes
Creators: name: Müller, Svenja
name: Moser, Dirk
name: Frach, Leonard
name: Wimberger, Pauline
name: Nitzsche, Katharina
name: Li, Shu-Chen
name: Kirschbaum, Clemens
name: Alexander, Nina
Publisher: name: figshare
Year: 2021
Subjects: subject: Molecular Biology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111402 Obstetrics and Gynaecology
subject: 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
subject: FOS: Psychology

description: Supplemental material for "No Long-Term Effects of Antenatal Synthetic Glucocorticoid Exposure on Epigenetic Regulation of Stress-Related Genes" by S. Müller, D. Moser, L. Frach, P. Wimberger, K. Nitzsche, S.-C. Li, C. Kirschbaum and N. Alexander submitted to the Journal of Clinical Endocrinology and Metabolism (JCEM)
Coping, information preferences, and treatment choice in men newly diagnosed with prostate cancer
Creators: name: Levin, Anna Yudit
Publisher: name: University of British Columbia
Year: 2011

description: Due to increased screening more men are being diagnosed with prostate cancer than ever before. In this case of early detection, several treatment options are appropriate, all impacting individuals’ quality of life and varying in their inherent risks. Further, the variety of treatment options available may not compromise survival as an outcome. Because of these factors, making a treatment decision can be particularly difficult for men, and information needs surrounding treatment decision making is an important clinical issue. In the current prospective study there are two data collection points: after diagnosis with prostate cancer at the time of treatment decision making, and approximately four months later, after a treatment decision has been made. Questionnaire data were used to investigate men’s disease-specific coping style and intolerance of uncertainty, information needs, level of preferred involvement in treatment decision making, knowledge regarding treatment options and side effects, emotional functioning and treatment choice. This project provides significant new knowledge concerning the coping style, information requirements, preferred level of involvement in treatment decision making, and emotional functioning of men at the time of treatment decision making. The study also examines the relative contributions of coping style and intolerance of uncertainty to anxiety and depression experienced by participants following treatment choice. Finally, this study explores the contribution of several variables to the types of treatments chosen by participants. In terms of coping, results indicate that monitoring and blunting were not related to distress indices. Both coping indices were related to information preferences at the time of diagnosis, but did not explain significant variance in preferred level of involvement in treatment decision making. Intolerance of uncertainty was predictive of time 2 depression, but not anxiety, but did not predict significant additional variance in depression over and above coping style. No study variable was found to be predictive of treatment choice. Results are discussed in terms of clinical implications for screening individuals newly diagnosed with prostate cancer, with the aim of meeting the emotional and informational needs of individuals during this critical period of their cancer trajectory.
Contact Moishezon threefolds with second Betti number one
Creators: name: Buczynski, Jaroslaw
name: Peternell, Thomas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 32J17, 53D10 (Primary) 14J30 (Secondary)

description: We prove that the only contact Moishezon threefold having second Betti number equal to one is the projective space.
description: 5 pages. v2: exposition improved as suggested by the referee. To appear in Archiv der Math
Τα ιδιαίτερα χαρακτηριστικά της Σασανιδικής σφραγιδογλυφίας, όπως αυτά αποτυπώνονται κατά τη θεματική παρουσίαση σαράντα μίας (41) Σασανιδικών σφραγίδων, που ανήκουν σε ελληνική ιδιωτική συλλογή.
Creators: name: Σιμιτζή, Σοφία
Publisher: name: National and Kapodistrian University of Athens
Year: 2024

description: The main subject of this study is the presentation of forty-one (41) unpublished seals of the Sasanian period, originating in Iran, that belong to an old Greek private collection.  In the first part of the study, a consolidated presentation was conducted for the special characteristics of Sasanian seals; the special shape of Sasanian seals, the types of semi-precious stones used, the way the seals were used by their owners, the stylistic performance of the depicted motif, the Pahlavi script and the highly recognizable pictorial subjects, which embody the political, social and religious perceptions of the Sasanids.   The forty-one (41) seals were organized and presented with criteria of the pictorial subject; human figures, animals sorted by species, birds, monograms and symbols related to Zoroastrianism. Due to the large quantity of seals depicting animals, additional information is given for each species of animal separately. Τhe study ends with some general conclusions, concerning numerical data and remarks on the possible owners of the seals.  The inscriptions on the three inscribed seals were translated by Professor Domenico Agostini (Dept. Of History, Tel Aviv University) and photos were taken by Stelios Skourlis (Hellenic Organization of Cultural Resources Development) to whom I am sincerely thankful.  
description: Περιοδικό του Τομέα Αρχαιολογίας και Ιστορίας της Τέχνης (AURA), Vol 7 (2024)
OCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo
Creators: name: Kou, Longfa
name: Sun, Rui
name: Xiao, Shuyi
name: Cui, Xiao
name: Sun, Jin
name: Ganapathy, Vadivel
name: Yao, Qing
name: Chen, Ruijie
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Targeted nanocarriers have shown great promise in drug delivery because of optimized drug behavior and improved therapeutic efficacy. How to improve the targeting efficiency of nanocarriers for the maximum possible drug delivery is a critical issue. Here we developed L-carnitine-conjugated nanoparticles targeting the carnitine transporter OCTN2 on enterocytes for improved oral absorption. As a variable, we introduced various lengths of the polyethylene glycol linker (0, 500, 1000, and 2000) between the nanoparticle surface and the ligand (CNP, C5NP, C10NP and C20NP) to improve the ligand flexibility, and consequently for more efficient interaction with the transporter, to enhance the oral delivery of the cargo load into cells. An increased absorption was observed in cellular uptake in vitro and in intestinal perfusion assay in situ when the polyethylene glycol was introduced to link L-carnitine to the nanoparticles; the highest absorption was achieved with C10NP. In contrast, the linker decreased the absorption efficiency in vivo. As the presence or absence of the mucus layer was the primary difference between in vitro/in situ versus in vivo, the presence of this layer was the likely reason for this differential effect. In summary, the size of the polyethylene glycol linker improved the absorption in vitro and in situ, but interfered with the absorption in vivo. Even though this strategy of increasing the ligand flexibility with the variable size of the polyethylene glycol failed to increase oral absorption in vivo, this approach is likely to be useful for enhanced cellular uptake following intravenous administration of the nanocarriers.