cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
KPZ equation limit of higher-spin exclusion processes
Creators: name: Corwin, Ivan
name: Tsai, Li-Cheng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We prove that under a particular weak scaling, the 4-parameter interacting particle system introduced by Corwin and Petrov converges to the KPZ equation. This expands the relatively small number of systems for which weak universality of the KPZ equation has been demonstrated.
description: 24 pages
Effects of Radiative Diffusion on Thin Flux Tubes in Turbulent Solar-like Convection
Creators: name: Weber, Maria A.
name: Fan, Yuhong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study the combined effects of convection and radiative diffusion on the evolution of thin magnetic flux tubes in the solar interior. Radiative diffusion is the primary supplier of heat to convective motions in the lower convection zone, and it results in a heat input per unit volume of magnetic flux tubes that has been ignored by many previous thin flux tube studies. We use a thin flux tube model subject to convection taken from a rotating spherical shell of turbulent, solar-like convection as described by Weber, Fan, and Miesch (2011, Astrophys. J., 741, 11; 2013, Solar Phys., 287, 239), now taking into account the influence of radiative heating on flux tubes of large-scale active regions. Our simulations show that flux tubes of less than or equal to 60 kG subject to solar-like convective flows do not anchor in the overshoot region, but rather drift upward due to the increased buoyancy of the flux tube earlier in its evolution as a result of the inclusion of radiative diffusion. Flux tubes of magnetic field strengths ranging from 15 kG to 100 kG have rise times of less than or equal to 0.2 years, and exhibit a Joy's Law tilt-angle trend. Our results suggest that radiative heating is an effective mechanism by which flux tubes can escape from the stably stratified overshoot region, and that flux tubes do not necessarily need to be anchored in the overshoot region to produce emergence properties similar to those of active regions on the Sun.
description: Accepted for publication to Solar Physics
(103511) Right Reverend Doctor Hedley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: I vincoli al bilancio dello Stato e delle pubbliche amministrazioni. Sovranità, autonomia e giurisdizione
Creators: name: Caldarelli, Sonia
Publisher: name: Roma TrE-Press
Year: 2020

description: Il volume si propone di fornire un quadro esaustivo delle riforme Europee e nazionali in materia di vincoli economici e di bilancio nei confronti dello Stato e delle sue articolazioni amministrative, al fine di vagliarne le ricadute sotto tre distinti profili: quello della Sovranità, che appare erosa dall’esistenza di un quadro di regolazione sovranazionale sempre più stringente e dall’esposizione debitoria degli Stati sul mercato dei capitali; quello dell’autonomia finanziaria delle pubbliche amministrazioni, con precipuo riferimento sia all’autonomia degli enti territoriali costituzionalmente garantita, che a quella delle pubbliche amministrazioni che, in ragione della generale capacità di diritto privato, si avvalgono degli strumenti offerti dall’ingegneria contrattuale e finanziaria; ed infine quello dei  confini (interni ed esterni) della giurisdizione, sulle controversie in cui venga in rilievo l’esigenza di tutela dell’interesse “ordinamentale” finanziario.
Potts model based on a Markov process computation solves the community structure problem effectively
Creators: name: Li, Hui-Jia
name: Wang, Yong
name: Wu, Ling-Yun
name: Zhang, Junhua
name: Zhang, Xiang-Sun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Potts model is a powerful tool to uncover community structure in complex networks. Here, we propose a new framework to reveal the optimal number of communities and stability of network structure by quantitatively analyzing the dynamics of Potts model. Specifically we model the community structure detection Potts procedure by a Markov process, which has a clear mathematical explanation. Then we show that the local uniform behavior of spin values across multiple timescales in the representation of the Markov variables could naturally reveal the network's hierarchical community structure. In addition, critical topological information regarding to multivariate spin configuration could also be inferred from the spectral signatures of the Markov process. Finally an algorithm is developed to determine fuzzy communities based on the optimal number of communities and the stability across multiple timescales. The effectiveness and efficiency of our algorithm are theoretically analyzed as well as experimentally validated.
description: 23 pages, 8 figures. arXiv admin note: text overlap with arXiv:0911.2308 by other authors
June Yip, Envisioning Taiwan: Fiction, Cinema, and the Nation in the Cultural Imaginary
Creators: Lupke, Christopher
Publisher: name: University of Alberta Library
Year: 2007

This is a review of June Yip's book Envisioning Taiwan: Fiction, Cinema, and the Nation in the Cultural Imaginary. The book is theoretically informed and focuses mainly in the works of two very important Taiwanese intellectuals: the filmmaker Hou Hsiao-hsien and the short story writer Huang Chunming. Although there are problems in the book, enumerated in the review, the book is a thoughtful, thorough, and theoretically informed treatment of Taiwanese culture and cultural production in the 1980s and 1990s.
Infima of length functions and dual cube complexes
Creators: name: Gaster, Jonah
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In the presence of certain topological conditions, we provide lower bounds for the infimum of the length function associated to a collection of curves on Teichmüller space that depend on the dual cube complex associated to the collection, a concept due to Sageev. As an application of our bounds, we obtain estimates for the `longest' curve with $k$ self-intersections, complementing work of Basmajian \cite{basmajian}.
description: 15 pages, 6 figures, published version
Spin superradiance by magnetic nanomolecules and nanoclusters
Creators: name: Yukalov, V. I.
name: Henner, V. K.
name: Yukalova, E. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin dynamics of assemblies of magnetic nanomolecules and nanoclusters can be made coherent by inserting the sample into a coil of a resonant electric circuit. Coherence is organized through the arising feedback magnetic field of the coil. The coupling of a magnetic sample with a resonant circuit induces fast spin relaxation and coherent spin radiation, that is, superradiance. We consider spin dynamics described by a realistic Hamiltonian, typical of magnetic nanomolecules and nanoclusters. The role of magnetic anisotropy is studied. A special attention is paid to geometric effects related to the mutual orientation of the magnetic sample and resonator coil.
description: latex file, 8 pages, 5 figures
COMPREHENSIVE INVESTIGATION OF LIGHT NEUTRON-RICH NUCLEI TO TEST MODERN NUCLEAR THEORETICAL MODELS
Creators: name: ZILIANI, SARA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Light nuclei, in particular the ones on the neutron-rich side of the valley of stability, represent a fertile ground to look for new experimental evidence, which can be exploited to benchmark theoretical approaches. In this Thesis we provide an experimental investigation of neutron-rich nuclei from boron to oxygen, employing state-of-the-art experimental techniques and detection systems. Novel information is collected and compared with the most advanced theoretical predictions currently available. The research activity described in this work has been developed on three levels, each associated to a different research line, that mirror the characteristic structure of a nucleus: bound states below the particle emission thresholds, near-threshold states and unbound resonances. In fact, the first line of research aims at the investigation of bound states in neutron-rich C, N and O isotopes, the second focuses on near-threshold resonances (11B as a specific case), and the third on stretched unbound states in the continuum of 13C, 14N and 16O. Altogether, a rather comprehensive body of experimental information will be discussed and confronted with some of the most advanced theoretical interpretations currently available for describing light atomic nuclei, such as ab initio approaches and Shell Model including the coupling to the continuum.
Innspelsmøte om prosjektet Kuratornettverk for FAIR forskingsdata, 9. november 2022
Creators: name: Conzett, Philipp
name: Høier, Svein
Publisher: name: Zenodo
Year: 2023
Subjects: research data
curation
network

description: Presentasjon på innspelsmøte til prosjektet Kuratornettverk for FAIR forskingsdata, 9. november 2022
(103512) Bishop Westminster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
IL TEMA DEL VIAGGIO INIZIATICO NELLA LETTERATURA DELL'AFRICA SUBSAHARIANA DALLA TRADIZIONE ORALE ALLA MODERNIZAZIONE ROMANZESCA (AMADOU HAMPATE' BA, AHMADOU KOUROUMA)
Creators: name: PARVIS, GIULIA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: This research work speaks about the initiation trip's subject in the African subsharian literature. Through a comparison between some oral tradition's tales (transcribed by Amadou Hampat� Ba) and two contemporary novels (L'�trange destin de Wangrin of Amadou Hampat� Ba and Monn�, outrages et d�fis of Ahmadou Kourouma), we analyze the subject's development from the oral to the written literature. In particular, we show how the colonization has changed the essence of this subject depending on the traditional vision. This study is seconded by the analysis of two essential variants of the selected subject: the character who makes the trip and the spaces where the journey happens. Our investigation also propose an historical and anthropological study on the initiation rites' general configuration and on the initiation in the writers' ethnic groups.
Future stability of the FLRW fluid solutions in the presence of a positive cosmological constant
Creators: name: Oliynyk, Todd A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We introduce a new method for establishing the future non-linear stability of perturbations of FLRW solutions to the Einstein-Euler equations with a positive cosmological constant and a linear equation of state of the form $p = K ρ$. The method is based on a conformal transformation of the Einstein-Euler equations that compactifies the time domain and can handle the equation of state parameter values $0
description: Corrected an error in the statement and proof of Theorem B.1. Due to this correction, the statement of the main theorem, Theorem 1.3, differs from the published version in that the 0j components of the metric satisfy slightly weaker decay estimates compared to the published version
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
Creators: name: Oloniniyi, O.K.
name: Laboune, F.
name: Zhou, T.
name: Roederer, M.
name: Hermanus, T.
name: Moore, P.L.
name: Chang, L.A.
name: DiPiazza, A.T.
name: Wang, L.
name: Stringham, C.D.
name: Antia, A.
name: Doria-Rose, N.A.
name: Widge, A.T.
name: Kwong, P.D.
name: Stephens, T.
name: Liu, T.
name: Zhang, Y.
name: Hatcher, C.
name: Martinez, D.R.
name: Olia, A.S.
name: Ledgerwood, J.E.
name: Darko, S.
name: Kgagudi, P.
name: O'Connell, S.
name: Choe, M.
name: Gordon, I.J.
name: Baric, R.S.
name: Davis, R.L.
name: Nazzari, A.F.
name: O'Dell, S.
name: Hait, S.H.
name: Zhang, B.
name: Graham, B.S.
name: Teng, I.-T.
name: Wagner, D.A.
name: Abiona, O.M.
name: Gaudinski, M.R.
name: Narpala, S.R.
name: Talana, C.A.
name: Douek, D.C.
name: Mascola, J.R.
name: McDermott, A.B.
name: Misasi, J.
name: Pegu, A.
name: Ruckwardt, T.J.
name: Novik, L.
name: Schramm, C.A.
name: Schmidt, S.D.
name: Mason, R.D.
name: Corbett, K.S.
name: Henry, A.R.
name: Yang, E.S.
name: Cale, E.M.
name: Shi, W.
name: Tsybovsky, Y.
name: Leung, K.
name: Phung, E.
name: Sullivan, N.J.
Publisher: name: American Association for the Advancement of Science
Year: 2021

description: IC80 1.5 to 34.5 nanograms per milliliter). We define the structural and functional determinants of binding for all four VOC-targeting antibodies and show that combinations of two antibodies decrease the in vitro generation of escape mutants, suggesting their potential in mitigating resistance development.
description: The emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identified four receptor binding domain-targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants, including the B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, and B.1.617 VOCs. Two antibodies are ultrapotent, with subnanomolar neutralization titers [half-maximal inhibitory concentration (IC50) 0.3 to 11.1 nanograms per milliliter
The association between intersystem prison transfers and COVID-19 incidence in a state prison system
Creators: name: Nguyen, P.
name: Volfovsky, A.
name: Brinkley-Rubinstein, L.
name: Nowotny, K.
name: LeMasters, K.
name: Cloud, D.
Publisher: name: Public Library of Science
Year: 2021

description: Prisons are the epicenter of the COVID-19 pandemic. Media reports have focused on whether transfers of incarcerated people between prisons have been the source of outbreaks. Our objective was to examine the relationship between intersystem prison transfers and COVID-19 incidence in a state prison system. We assessed the change in the means of the time-series of prison transfers and their cross-correlation with the time-series of COVID-19 tests and cases. Regression with automatic detection of multiple change-points was used to identify important changes to transfers. There were over 20,000 transfers between the state’s prisons from January through October 2020. Most who were transferred (82%), experienced a single transfer. Transfers between prisons are positively related to future COVID-19 case rates but transfers are not reactive to current case rates. To mitigate the spread of COVID-19 in carceral settings, it is crucial for transfers of individuals between facilities to be limited.
RESUMMATIONS OF TRANSVERSE MOMENTUM DISTRIBUTIONS
Creators: name: MUSELLI, CLAUDIO
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: This thesis arises in the context of precise phenomenology at the Large Hadron Collider, LHC. In the searching for New Physics, an accurate theoretical prediction of many Standard Model processes is crucial to be able to distinguish the desired discrepancy from the known background. After the failure of LHC Run I in the detection of any trace of new physics, experimental search is moving from inclusive cross sections to more exclusive shapes and distributions. In this context, primary importance is covered by transverse momentum distributions. The objective of this thesis is to provide a general study about possible resummation theories which can be applied on transverse momentum distributions. In particular, the known transverse momentum resummation and threshold resummation formalism are reviewed and improved, being able to unify all this information in a unique combined expression. Moreover in the context of high energy resummation, several new ingredients are introduced in this thesis: LL$x$ resummation is performed for the double differential distribution, and first steps in the extension of this formalism to jets are discussed. As phenomenological applications, a combined resummed result is shown for the Higgs boson transverse momentum distribution; furthermore the impact of quark mass corrections on this spectrum at LHC $13$ TeV is analysed, using an high energy expansion.
(103513) Bishop of Southwark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title:  Postmortem Exercise of Data Protection Rights: the Apple Case
Creators: name: Vigorito  ,  Andrea
Publisher: name: Roma TrE-Press
Year: 2021

description: The paper aims at developing the debate on digital inheritance by analyzing its first judicial application in Italy. In this decision, the Court applied Article 2-terdecies, d.lgs 196/2003 and took a crucial step with regard to the legal regime of personal data – and, more broadly, of digital resources – after the data subject’s death. The Italian legislation, as this decision shows, seems to have adopted a ‘personalistic model’ through which not only heirs and relatives, but any person showing a legitimate interest could exercise the data subject’s rights on personal data. After a brief introduction of the main themes concerning the postmortal exercise of data (1.), this essay analyzes the reasons behind the judicial decision (2.) and seeks to further explore the dogmatic qualification of the rights on personal data recognized by the legislator with Article 2-terdecies (3.).
description: Roma Tre Law Review – 02/2021
(103515) Sarah Thomas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Balancing open for ECRs
Creators: name: Gould van Praag, Cassandra
Publisher: name: Zenodo
Year: 2022

description: My thoughts for a panel discussion on "Balancing Open for ECRs" at the Oxford Berlin Summer School on Open Research, 2022. Brief: Speak for 8 minutes on viable strategies for ECRs to incorporate and balance open science activity with their research and career development. Qs to cover: How can open research contribute to career development? Where are the limits of open research? What services/strategies exist to ease opening up research? What case studies do you know of where open research really made a difference? Where do you see need for additional development to further open up research? Can you think of examples where open science can actually be detrimental to scientific progress? Who should provide quality control on open data, code, and protocols? In how far are preregistrations helpful to establish rigorous research?
BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2
Creators: name: CANCELLIERI, CINZIA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Chemokines promote leukocyte migration through the activation of dedicated G-protein coupled receptors. Beyond conventional chemokine receptors, which directly induce cell migration through heterotrimeric G?i-mediated signalling events, a set of atypical chemokine receptors (ACKRs) have been described. ACKRs do not activate G?i-mediated signalling activity, but they are mainly involved in shaping the chemokine gradient. The best characterized member of this family is ACKR2. ACKR2, previously referred to as D6, is a scavenger receptor that binds with high affinity to 13 inflammatory CC chemokines. The scavenging activity of ACKR2 relies on its intracellular traffic properties. Under homeostatic conditions, ACKR2 is mainly localized in intracellular stores associated with both early Rab4/5-positive and recycling Rab11-positive endosomes. At increasing levels of chemokines, ACKR2 increases plasma membrane abundance through an acceleration in the rate of Rab11-depedent recycling pathway, in order to optimize its chemokine scavenging activity. Here, I demonstrated that the intracellular distribution of ACKR2 is maintained by cytoskeletal dynamics. After chemokine engagement, ACKR2 activate a G-protein-independent and ?-arrestin-dependent Rac1-PAK1-LIMK1 signalling cascade to finely regulate the actin cytoskeletal and the microtubules network reorganization, to promote receptor up-regulation and scavenging function. ACKR2 is able to recruit and associates both ?-arrestins in basal condition, at membrane and intracellular levels, but only ?-arrestin1 is recruited after active ligand stimulation, in order to promote a ?-arrestin1-dependent signalling pathway, required for supporting the myosin Vb-dependent ACKR2 up-regulation and scavenging properties.
Constraints on black hole massess with timescales of variations in blazars
Creators: name: Liu, H. T.
name: Bai, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this paper, we investigated the issue of black hole masses and minimum timescales of jet emission for blazars. We proposed a sophisticated model that sets an upper limit to the central black hole masses $M_{\bullet}$ with the minimum timescales $Δt^{\rm{ob}}_{\rm{min}}$ of variations observed in blazars. The value of $Δt^{\rm{ob}}_{\rm{min}}$ presents an upper limit to the size of blob in jet. The blob is assumed to be generated in the jet-production region in the vicinity of black hole, and then the expanding blob travels outward along the jet. We applied the model to 32 blazars, 29 of which were detected in gamma rays by satellites, and these $Δt^{\rm{ob}}_{\rm{min}}$ are on the order of hours with large variability amplitudes. In general, these $M_{\bullet}$ estimated with this method are not inconsistent with those masses reported in the literatures. This model is natural to connect $M_{\bullet}$ with $Δt^{\rm{ob}}_{\rm{min}}$ for blazars, and seems to be applicable to constrain $M_{\bullet}$ in the central engines of blazars.
description: 17 pages, 2 figures, 1 table, submitted to AJ
SPACELIKE HYPERSURFACES IN GENERALIZED ROBERTSON-WALKER SPACETIMES
Creators: name: SCOLERI, SIMONA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The object of study are complete spacelike hypersurfaces in a generalized Robertson-Walker spacetime. We make use of a new local form of the weak maximum principle for a class of operators including the Lorentzian mean curvature operator in order to obtain some mean curvature estimates and height estimates for spacelike hypersurfaces. These estimates are related to some rigidity results. We also give height estimates for spacelike hypersurfaces with constant higher order mean curvature, which are obtained via the local form of the weak maximum principle for an appropriate class of operators.
(103509) Cardinal Prefect
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals
Creators: name: Martinez, David R.
name: Lerner, Aaron
name: Cornaby, Caleb
name: Baric, Ralph
name: Giallourou, Natasa
name: Premkumar, Lakshmanane
name: Graham, Stephen D.
name: Markmann, Alena J.
name: Kuruc, JoAnn
name: Bhowmik, D. Ryan
name: Schmitz, John
name: Hou, Yixuan J.
name: de Silva, Aravinda M.
name: van Duin, David
name: Napravnik, Sonia
name: Margolis, David M.
name: Weiss, Susan
name: Park, Yara
name: Guerra, Quique
name: Bartelt, Luther A.
name: Wrin, Terri
name: Petropoulos, Christos J.
name: Raut, Rajendra
name: Root, Heather
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2 months after infection or the reason for the discrepancy in COVID-19 disease and sex. Using convalescent-phase sera collected from 101 COVID-19-recovered individuals 21 to 212 days after symptom onset with 48 additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations of individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to 6 months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex and in individuals with cardiometabolic comorbidities. IMPORTANCE In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary in magnitude but are durable and correlate well with receptor binding domain (RBD) Ig binding antibody levels compared to other SARS-CoV-2 antigen responses. In our cohort, higher neutralizing antibody titers are independently and significantly associated with male sex compared to female sex. We also show for the first time that higher convalescent antibody titers in male donors are associated with increased age and symptom grade. Furthermore, cardiometabolic comorbidities are associated with higher antibody titers independently of sex. Here, we present an indepth evaluation of serologic, demographic, and clinical correlates of functional antibody responses and durability to SARS-CoV-2 which supports the growing literature on sex discrepancies regarding COVID-19 disease morbidity and mortality, as well as functional neutralizing antibody responses to SARS-CoV-2.
$G_2$-instantons over twisted connected sums: an example
Creators: name: Walpuski, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 53C07, 53C25, 53C38, 14D20, 14J28

description: Using earlier work of Sá Earp and the author [SEW13] we construct an irreducible unobstructed $G_2$-instanton on an $\mathrm{SO}(3)$-bundle over a twisted connected sum recently discovered by Crowley-Nordström [CN14].
description: v2: published version
Rede auf einer Konferenz von Kadern der Propaganda-, Theorie-, Presseabteilungen und Parteischulen (Zhao Ziyang, 13. Mai 1987)
Creators: name: Redaktion, Die
name: Jen-Kai, Liu
Publisher: name: China aktuell
Year: 2023

description: China aktuell, China aktuell - Juli 1987
(103510) Louisa Jones
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Your health is in your hands? US CDC COVID-19 mask guidance reveals the moral foundations of public health
Creators: name: Tomori, Cecilia
name: Meier, Benjamin Mason
name: Evans, Dabney P.
name: Ahmed, Aziza
name: Nair, Aparna
Publisher: name: Elsevier
Year: 2021

description: In the second year of the COVID-19 pandemic, US public health policy remains at a crossroads. The US Centers for Disease Control and Prevention’s (CDC’s) May 28, 2021 guidance, which lifted masking recommendations for vaccinated people in most situations, exemplifies a troubling shift—away from public health objectives that center equity and toward a model of individual personal responsibility for health. CDC Director Rochelle Walensky emphasized that “your health is in your hands”, undermining the idea that fighting COVID is a “public” health responsibility that requires the support of institutions and communities. The social impacts of this scientific guidance, combined with the emergence of new variants, have exposed the fallacy of this approach, with most local mask restrictions lifted and infections rising dramatically among disadvantaged populations. Rapidly rising cases prompted the CDC on July 27th to recommend resuming indoor masking even for vaccinated people in “areas of substantial or high transmission”, but US policy continues to frame the pandemic largely as a matter of individual responsibility—to the detriment of public health. As public health professionals and advocates, we call for a renewed commitment to core public health principles of collective responsibility, health equity, and human rights.
Supplementary information from Genotype-specific relationships among phosphorus use, growth and abundance in Daphnia pulicaria.
Creators: name: Sherman, Ryan E.
name: Chowdhury, Priyanka Roy
name: Baker, Kristina D.
name: Weider, Lawrence J.
name: Punidan D. Jeyasingh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Supplementary Tables S1, S2, S3, S4
Galois groups and group actions on Lie algebras
Creators: name: Agore, A. L.
name: Militaru, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: Mathematical Physics (math-ph)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: If $\mathfrak{g} \subseteq \mathfrak{h}$ is an extension of Lie algebras over a field $k$ such that ${\rm dim}_k (\mathfrak{g}) = n$ and ${\rm dim}_k (\mathfrak{h}) = n + m$, then the Galois group ${\rm Gal} \, (\mathfrak{h}/\mathfrak{g})$ is explicitly described as a subgroup of the canonical semidirect product of groups ${\rm GL} (m, \, k) \rtimes {\rm M}_{n\times m} (k)$. An Artin type theorem for Lie algebras is proved: if a group $G$ whose order isinvertible in $k$ acts as automorphisms on a Lie algebra $\mathfrak{h}$, then $\mathfrak{h}$ is isomorphic to a skew crossed product $\mathfrak{h}^G \, \#^{\bullet} \, V$, where $\mathfrak{h}^G$ is the subalgebra of invariants and $V$ is the kernel of the Reynolds operator. The Galois group ${\rm Gal} \,(\mathfrak{h}/\mathfrak{h}^G)$ is also computed, highlighting the difference from the classical Galois theory of fields where the corresponding group is $G$. The counterpart for Lie algebras of Hilbert's Theorem 90 is proved and based on it the structure of Lie algebras $\mathfrak{h}$ having a certain type of action of a finite cyclic group is described. Radical extensions of finite dimensional Lie algebras are introduced and it is shown that their Galois group is solvable. Several applications and examples are provided.
description: final version
Pulmonary neuroendocrine cells secrete γ-aminobutyric acid to induce goblet cell hyperplasia in primate models
Creators: name: Randell, S.H.
name: Miller, L.A.
name: Mitchel, J.A.
name: Park, J.-A.
name: Barrios, J.
name: Kho, A.T.
name: Aven, L.
name: Tantisira, K.G.
name: Ai, X.
Publisher: name: American Thoracic Society
Year: 2019

description: Mucus overproduction is a major contributor to morbidity and mortality in asthma. Mucus overproduction is induced by orchestrated actions of multiple factors that include inflammatory cytokines and γ-aminobutyric acid (GABA).GABAis produced only by pulmonary neuroendocrine cells (PNECs) in the mouse lung. Recent studies in a neonatal mouse model of allergic inflammation have shown that PNECs play an essential role in mucus overproduction by GABA hypersecretion. Whether PNECs mediate dysregulatedGABAsignaling for mucus overproduction in asthma is unknown. In this study, we characterized the cellular source ofGABA in the lungs of nonhuman primates and humans and assessed GABA secretion and signaling in primate disease models.Wefound that like in mice, PNECs were the major source of GABA in primate lungs. In addition, an infant nonhuman primate model of asthma exhibited an increase in GABA secretion. Furthermore, subjects with asthma had elevated levels of expression of a subset of GABA type a (GABAa) and type b (GABAb) receptors in airway epithelium compared with those of healthy control subjects. Last, employing a normal human bronchial epithelial cell model of preinduced mucus overproduction, we showed pharmaceutical blockade of GABAa and GABAb receptor signaling reversed the effect of IL-13 on MUC5AC gene expression and goblet cell proliferation. Together, our data demonstrate an evolutionarily conserved intraepithelial GABA signaling that, in concert with IL-13, plays an essential role in mucus overproduction. Our findings may offer new strategies to ameliorate mucus overproduction in patients with asthma by targeting PNEC secretion and GABA signaling.
title: Impacto de la metodología del aprendizaje basado en casos sobre la empatía y el actuar médico en los médicos residentes
Creators: name: Paque Bautista, Carlos
Publisher: name: Tecnológico de Monterrey
publisherIdentifier: https://ror.org/03ayjn504
publisherIdentifierScheme: ROR
Year: 2023
Subjects: classificationCode: 5.3
subject: FOS: Educational sciences

description: Actualmente la atención médica presenta áreas de oportunidad por parte de los médicos en formación en la UMAE HGP No 48 del Instituto Mexicano del Seguro Social. Existen reportes de los derechohabientes manifestando que no se tiene un trato digno y que no son respetados sus derechos como pacientes. También se menciona la falta de empatía por parte del personal de la salud al momento de recibir atención médica. Debido a esto, se decidió realizar la implementación de este proyecto de intervención como un medio para la resolución de esa falta de empatía en los médicos residentes. El objetivo del proyecto es analizar el impacto que tiene un taller del aprendizaje basado en casos sobre la empatía y el actuar médico. Como instrumentos de diagnóstico se utilizaron cuestionarios que permitieron conocer el nivel de empatía y el conocimiento en materia de derechos de los pacientes, Ley General de Salud, y ética médica. El taller tuvo una duración de 4 sesiones. Los resultados indican que la metodología de casos sobre la empatía fue exitosa, ya que los puntajes de los participantes posteriores al taller mejoraron sustancialmente en comparación con la evaluación inicial. También se observó mejoría en el puntaje en la evaluación del conocimiento, y una percepción promedio favorable sobre la metodología de aprendizaje basado en casos. En general, los residentes manifestaron estar motivados para ser más empáticos con los pacientes que atienden.
Intercellular communication between airway epithelial cells is mediated by exosome-like vesicles
Creators: name: Dang, H.
name: Kesimer, M.
name: Radicioni, G.
name: Carpenter, J.
name: Chua, M.
name: Sheridan, J.T.
name: Randell, S.H.
name: Mieczkowski, P.A.
name: Abdelwahab, S.
name: Gupta, R.
Publisher: name: American Thoracic Society
Year: 2019

description: Airway epithelium structure/function can be altered by local inflammatory/immune signals, and this process is called epithelial remodeling. The mechanism by which this innate response is regulated, which causes mucin/mucus overproduction, is largely unknown. Exosomes are nanovesicles that can be secreted and internalized by cells to transport cellular cargo, such as proteins, lipids, and miRNA. The objective of this study was to understand the role exosomes play in airway remodeling through cell–cell communication. We used two different human airway cell cultures: primary human tracheobronchial (HTBE) cells, and a cultured airway epithelial cell line (Calu-3). After intercellular exosomal transfer, comprehensive proteomic and genomic characterization of cell secretions and exosomes was performed. Quantitative proteomics and exosomal miRNA analysis profiles indicated that the two cell types are fundamentally distinct. HTBE cell secretions were typically dominated by fundamental innate/protective proteins, including mucin MUC5B, and Calu-3 cell secretions were dominated by pathology-associated proteins, including mucin MUC5AC. After exosomal transfer/intake, approximately 20% of proteins, including MUC5AC and MUC5B, were significantly altered in HTBE secretions. After exosome transfer, approximately 90 miRNAs (z4%) were upregulated in HTBE exosomes, whereas Calu-3 exosomes exhibited a preserved miRNA profile. Together, our data suggest that the transfer of exosomal cargo between airway epithelial cells significantly alters the qualitative and quantitative profiles of airway secretions, including mucin hypersecretion, and the miRNA cargo of exosomes in target cells. This finding indicates that cellular information can be carried between airway epithelial cells via exosomes, which may play an important role in airway biology and epithelial remodeling.
Supplementary information from Genotype-specific relationships among phosphorus use, growth and abundance in Daphnia pulicaria
Creators: name: Sherman, Ryan E.
name: Chowdhury, Priyanka Roy
name: Baker, Kristina D.
name: Weider, Lawrence J.
name: Punidan D. Jeyasingh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Supplementary Tables S1, S2, S3, S4
Hourly values of an advanced human-biometeorological index for diverse populations from 1991 to 2020: Replicability and exploitability aspects
Creators: name: Giannaros, Christos
name: Agathangelidis, Ilias
name: Galanaki, Elissavet
name: Cartalis, Constantinos
name: Kotroni, Vassiliki
name: Lagouvardos, Kostas
name: Giannaros, Theodore
name: Tzyrkalli, Anna
name: Economou, Theodoros
name: Matzarakis, Andreas
Publisher: name: Zenodo
Year: 2024

description: This presentation was given at the 2024 Annual Meeting of the European Meteorological Society in Barcelona, Spain (2-6 September). It provides information on the creation, replication and exploitation of a novel human thermal bioclimate dataset, which was developed in the framework of the HEAT-ALARM ("Development of a heat-health warning system in Greece") research project. The dataset is publicly available at: https://doi.org/10.5281/zenodo.10893914.
Normality in Pisot Numeration Systems
Creators: name: Scheerer, Adrian-Maria
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 11K16 (Primary), 37A45 (Secondary)

description: Copeland and Erdős showed that the concatenation of primes when written in base $10$ yields a real number that is normal to base $10$. We generalize this result to Pisot number bases in which all integers have finite expansion.
description: 11 pages
The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion
Creators: name: Thornton, D.J.
name: Jowitt, T.A.
name: Kesimer, M.
name: Subramani, D.B.
name: Lockhart-Cairns, M.P.
name: Ridley, C.
name: Collins, R.F.
name: Baldock, C.
Publisher: name: American Society for Biochemistry and Molecular Biology Inc.
Year: 2019

description: Mucin 5B (MUC5B) has an essential role in mucociliary clearance that protects the pulmonary airways. Accordingly, knowledge of MUC5B structure and its interactions with itself and other proteins is critical to better understand airway mucus biology and improve the management of lung diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The role of an N-terminal multimerization domain in the supramolecular organization of MUC5B has been previously described, but less is known about its C-terminal dimerization domain. Here, using cryogenic electron microscopy (cryo-EM) and small-angle X-ray scattering (SAXS) analyses of recombinant disulfide-linked dimeric MUC5B dimerization domain we identified an asymmetric, elongated twisted structure, with a double globular base. We found that the dimerization domain is more resistant to disruption than the multimerization domain suggesting the twisted structure of the dimerization domain confers additional stability to MUC5B polymers. Size-exclusion chromatography-multiangle light scattering (SEC-MALS), SPR-based biophysical analyses and microscale thermophoresis of the dimerization domain disclosed no further assembly, but did reveal reversible, calciumdependent interactions between the dimerization and multimerization domains that were most active at acidic pH, suggesting that these domains have a role in MUC5B intragranular organization. In summary, our results suggest a role for the C-terminal dimerization domain of MUC5B in compaction of mucin chains during granular packaging via interactions with the N-terminal multimerization domain. Our findings further suggest that the less stable multimerization domain provides a potential target for mucin depolymerization to remove mucus plugs in COPD and other lung pathologies.
(103503) William Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Gravitational instantons with faster than quadratic curvature decay (I)
Creators: name: Chen, Gao
name: Chen, Xiuxiong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper, we study gravitational instantons (i.e., complete hyperkäler 4-manifolds with faster than quadratic curvature decay). We prove three main theorems: 1.Any gravitational instanton must have known end----ALE, ALF, ALG or ALH. 2.In ALG and ALH-non-splitting cases, it must be biholomorphic to a compact complex elliptic surface minus a divisor. Thus, we confirm a long-standing question of Yau in ALG and ALH cases. 3.In ALF-D_k case, it must have an O(4)-multiplet.