cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel pre-burst stage of gamma-ray bursts from machine learning
Creators: name: Chen, Yingtian
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Gamma-ray bursts (GRBs), as extremely energetic explosions in the universe, are widely believed to consist of two stages: the prompt phase and the subsequent afterglow. Recent studies indicate that some high-energy photons are emitted earlier at source than the prompt phase. Due to the light speed variation, these high-energy photons travel slowly than the low-energy photons, so that they are observed after the prompt low-energy photons at the detector. Based on the data from the Fermi Gamma-ray Space Telescope (FGST), we analyse the photon distribution before the prompt emission in detail and propose the existence of a hitherto unknown pre-burst stage of GRBs by adopting a classification method of machine learning. Analysis on the photons automatically selected by machine learning also produce a light speed variation at $E_{\mathrm{LV}}=\mathrm{3.55\times 10^{17} GeV}$.
description: 13 latex pages, 12 figures, final version for publication
Development and validation of an eco-friendly, stability-indicating UV spectroscopic method for trigonelline analysis in nanoformulation using quality by design approach
Creators: name: Umarani, Adarsh C
name: Patil, Akshay K
name: Karadesai, Manikant B
name: Mandi, Praneeth N
name: Patil, Sneha B
name: Jalalpure, Sunil S
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Background: Trigonelline is an alkaloid known for its therapeutic potentials. The present study aims to develop a stability-indicating, Quality by Design-based eco-friendly UV spectroscopic method for the estimation of trigonelline in nanoformulation. Methodology: Water was used as the principal solvent. The method was optimized using a design of experiments approach. Critical process parameters were identified as sonication time and scanning interval, while absorbance was designated as the critical quality attribute. The optimized parameters (10-minute sonication time and low scanning interval) were validated according to ICH guidelines. A forced degradation study was also conducted. Results: A linear relationship was confirmed at concentrations ranging from 5 to 25 μg/ml, with an R2 value of 0.999 at 265 nm. The precision assays showed a %RSD of less than 2, indicating high precision. The recovery percentages ranged from 99.56% to 101.85%, indicating reliable accuracy. The method revealed LOD and LOQ values of 0.66 μg/mL and 2.00 μg/mL, respectively, underscoring its sensitive characteristics. The method demonstrated both rugged and robust characteristics. The assays for acidic, basic and oxidative stability indicated a degradation range of 24.84% to 35.95%, while thermal degradation exhibited a significant degradation level of 51.23%. The developed UV spectroscopic method successfully quantified trigonelline in the nanoformulation. Conclusion: This QbD-driven UV spectroscopic method provides a valuable tool for trigonelline analysis in nanoformulation, offering rapid analysis, high accuracy with low detection limits.
Identification of Market Power in Bilateral Oligopoly: The Brazilian Wholesale Market of UHT Milk
Creators: name: Scalco, Paulo R.
name: Braga, Marcelo J.
name: Scalco, Paulo R.
name: Braga, Marcelo J.
Publisher: name: Unknown
Year: 2015
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: International Development
subject: Marketing
subject: FOS: Economics and business

description: The aim of this study was to test the hypothesis of market power in the wholesale market for UHT milk. The structure of this market is an oligopoly characterized as bilateral and uses the model proposed by Schroeter et al. (2000), which allows testing the hypothesis of market power without assuming the restrictive hypothesis of price-taking behavior on one side of the market. The system of nonlinear simultaneous equations that determines quantity, wholesale and retail prices of UHT milk was estimated by nonlinear generalized method of moments. Estimation of conduct parameter was 0.638, rejecting the hypothesis of a perfectly competitive market. Evidences suggest that retailers exert oligopsony power on the dairy industry; however, the distortions caused by such market power could not be quantified.
dHybridR: a Hybrid--Particle-in-Cell Code Including Relativistic Ion Dynamics
Creators: name: Haggerty, Colby C.
name: Caprioli, Damiano
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present the first plasma simulations obtained with the code dHybridR, a hybrid particle-in-cell code with fluid electrons and both thermal and energetic ions that retain relativistic dynamics. dHybridR is constructed to study astrophysical and space-physics problems where a few energetic non-thermal particles (i.e., cosmic rays, CRs) affect the overall dynamics of a non-relativistic plasma, such as CR-driven instabilities, collisionless shocks, magnetic reconnection, turbulence, etc.In this method paper we provide some applications to linear (resonant/non-resonant CR streaming instability) and strongly non-linear (parallel shocks) problems that show the capabilities of the code. In particular, we provide the first self-consistent hybrid runs that show the acceleration of relativistic ions at non-relativistic shocks; CRs develop a power-law in momentum, which translates to a broken power law in energy that exhibits a steepening around the ion rest mass, as predicted by the theory of diffusive shock acceleration. We present examples of 2D dHybridR runs relevant for fast shocks in radio supernovae, whose evolution can be followed in real time, and 3D runs of low-Mach-number heliospheric shocks, which can be compared with in-situ spacecraft observations.
description: 14 pages, 12 figures, 1 table
A new benchmark problem for electromagnetic modelling of superconductors: the high- T c superconducting dynamo
Creators: name: Ainslie, Mark
name: Grilli, Francesco
name: Quéval, Loïc
name: Pardo, Enric
name: Perez-Mendez, Fernando
name: Mataira, Ratu
name: Morandi, Antonio
name: Ghabeli, Asef
name: Bumby, Chris
name: Brambilla, Roberto
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Paper
HTS dynamo
flux pump
coated conductor
numerical simulation
HTS modelling
high temperature superconductors

description: Abstract: The high-T c superconducting (HTS) dynamo is a promising device that can inject large DC supercurrents into a closed superconducting circuit. This is particularly attractive to energise HTS coils in NMR/MRI magnets and superconducting rotating machines without the need for connection to a power supply via current leads. It is only very recently that quantitatively accurate, predictive models have been developed which are capable of analysing HTS dynamos and explain their underlying physical mechanism. In this work, we propose to use the HTS dynamo as a new benchmark problem for the HTS modelling community. The benchmark geometry consists of a permanent magnet rotating past a stationary HTS coated-conductor wire in the open-circuit configuration, assuming for simplicity the 2D (infinitely long) case. Despite this geometric simplicity the solution is complex, comprising time-varying spatially-inhomogeneous currents and fields throughout the superconducting volume. In this work, this benchmark problem has been implemented using several different methods, including H-formulation-based methods, coupled H-A and T-A formulations, the Minimum Electromagnetic Entropy Production method, and integral equation and volume integral equation-based equivalent circuit methods. Each of these approaches show excellent qualitative and quantitative agreement for the open-circuit equivalent instantaneous voltage and the cumulative time-averaged equivalent voltage, as well as the current density and electric field distributions within the HTS wire at key positions during the magnet transit. Finally, a critical analysis and comparison of each of the modelling frameworks is presented, based on the following key metrics: number of mesh elements in the HTS wire, total number of mesh elements in the model, number of degrees of freedom, tolerance settings and the approximate time taken per cycle for each model. This benchmark and the results contained herein provide researchers with a suitable framework to validate, compare and optimise their own methods for modelling the HTS dynamo.
Error Thresholds for Arbitrary Pauli Noise
Creators: name: Bausch, Johannes
name: Leditzky, Felix
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: 81P45, 94C15, 94B99, 94A17

description: The error threshold of a one-parameter family of quantum channels is defined as the largest noise level such that the quantum capacity of the channel remains positive. This in turn guarantees the existence of a quantum error correction code for noise modeled by that channel. Discretizing the single-qubit errors leads to the important family of Pauli quantum channels; curiously, multipartite entangled states can increase the threshold of these channels beyond the so-called hashing bound, an effect termed superadditivity of coherent information. In this work, we divide the simplex of Pauli channels into one-parameter families and compute numerical lower bounds on their error thresholds. We find substantial increases of error thresholds relative to the hashing bound for large regions in the Pauli simplex corresponding to biased noise, which is a realistic noise model in promising quantum computing architectures. The error thresholds are computed on the family of graph states, a special type of stabilizer state. In order to determine the coherent information of a graph state, we devise an algorithm that exploits the symmetries of the underlying graph, resulting in a substantial computational speed-up. This algorithm uses tools from computational group theory and allows us to consider symmetric graph states on a large number of vertices. Our algorithm works particularly well for repetition codes and concatenated repetition codes (or cat codes), for which our results provide the first comprehensive study of superadditivity for arbitrary Pauli channels. In addition, we identify a novel family of quantum codes based on tree graphs. The error thresholds of these tree graph states outperform repetition and cat codes in large regions of the Pauli simplex, and hence form a new code family with desirable error correction properties.
description: 56 pages, 20 figures; code repositories available at https://github.com/rumschuettel/CoffeeCode and https://github.com/felixled/graph-states-coherent-info
Expression and bioactivity analysis of TNF30, a TNFα nanobody, in Escherichia coli
Creators: name: Li, Qian
name: Miao, Zhi
name: Luo, Xue-Gang
name: Zhao, Jian
name: Song, Ya-Jian
name: Li, Zhong-Yuan
name: Zhou, Hao
name: Zhang, Tong-Cun
name: Mao, Li-Song
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Antibodies and antagonists targeting tumour necrosis factor alpha (TNFα) have become a number of the best-selling anti-inflammatory drugs. The nanobody is a single domain antibody derived from the variable domain of a heavy-chain antibody. However, so far, there are still no reports on the recombinant expression of TNFα nanobodies. Here, TNF30, the key anti-TNFα nanobody domain of ozoralizumab, was cloned, expressed in Escherichia coli, and then purified with the Ni2+-chelating affinity chromatography. The western blot results showed that the recombinant TNF30 has strong binding capability with TNFα. Furtermore, the pharmacological and histopathological analysis in the carrageenan-induced mice paw oedema demonstrated that the recombinant nanobodies had potential anti-inflammatory activity in vivo. These works provided a novel approach for the production of TNF30 in E. coli, and might establish a foundation for the industrial production of the drug and the development of more active derivatives against TNFα in the future.
Dynomene pilumnoides Alcock 1900
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Dynomenidae
Dynomene
Dynomene pilumnoides

description: Dynomene pilumnoides Alcock, 1900
 Dynomene pilumnoides Alcock, 1900a: 133 [type locality: Laccadive Is.; holotype: IM 9000 /6].
 Hawaiian Is. record:
 Dynomene pilumnoides Alcock, 1900 — McLay 1999: 494, figs. 3c, d, 8d, e, 12e, f, 14c, 21 [Moloka‘i].
 Taxonomy. McLay (1999), McLay & Ng (2005)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Shallow subtidal to bathyal, 18–403 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 34, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
Field-induced structure transformation in electrorheological solids
Creators: name: Lo, C. K.
name: Yu, K. W.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have computed the local electric field in a body-centered tetragonal (BCT) lattice of point dipoles via the Ewald-Kornfeld formulation, in an attempt to examine the effects of a structure transformation on the local field strength. For the ground state of an electrorheological solid of hard spheres, we identified a novel structure transformation from the BCT to the face-centered cubic (FCC) lattices by changing the uniaxial lattice constant c under the hard sphere constraint. In contrast to the previous results, the local field exhibits a non-monotonic transition from BCT to FCC. As c increases from the BCT ground state, the local field initially decreases rapidly towards the isotropic value at the body-centered cubic lattice, decreases further, reaching a minimum value and increases, passing through the isotropic value again at an intermediate lattice, reaches a maximum value and finally decreases to the FCC value. An experimental realization of the structure transformation is suggested. Moreover, the change in the local field can lead to a generalized Clausius-Mossotti equation for the BCT lattices.
description: Submitted to Phys. Rev. E
Hexagonal boron nitride at low temperatures: controlled synthesis and mechanism
Creators: name: Mog, Tanima
name: Debnath, Ranjit
name: Saha, Mitali
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: As a structural counterpart of graphite, hexagonal boron nitride (hBN) exhibits distinct advantages over bulk hBN, including high thermal conductivity and electrical insulation, exceptional strength, low friction coefficient as well as high elastic modulus, which make it a unique material for wide variety of applications. Despite this, the controlled and scalable synthesis of hBN, maintaining a stoichiometric balance between boron and nitrogen atoms during crystal growth has remained a daunting challenge in the last few decades. Herein, a simple yet efficient method was employed to optimize the heat-treatment of urea, thiourea, and boric acid at melting temperatures. This resulted in the synthesis of hBNs at very low temperatures in a single step, under normal atmospheric conditions. The FESEM images of hBN produced from both urea and thiourea showed the formation of hexagonal layered structure of boron nitrides. The high magnified TEM images clearly depicted the lattice fringes within the hBN. The overall results confirmed that V-shape of urea and thiourea might have helped to produce hBNs in large scale, bypassing the use of substrates, high temperature or pressure.
Synthesis, impurity profiling, simultaneous NP-HPTLC method development, molecular modelling study and EGFR tyrosine kinase inhibitory profile: An integrated approach to characterize desethynyl erlotinib process impurity
Creators: name: Bhadane, Kunal
name: Patil, Bhatu
name: Chinnam, Sampath
name: Das, Biswajit
name: Patil, Chandragouda
name: Gawli, Chandrakant
name: Ahmad, Iqrar
name: Shimpi, Amit
name: Agrawal, Yogesh
name: Patil, Amod
name: Shirkhedkar, Atul
name: Rai, Nishant
name: Palkar, Mahesh
name: Ansari, Siddique Akber
name: Ansari, Irfan Aamer
name: Kundu, Chanakya Nath
name: Patel, Harun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The study presents an integrated approach to characterizing Desethynyl Erlotinib, a process impurity in the synthesis of Erlotinib, a potent EGFR tyrosine kinase (EGFR TK) inhibitor used in lung cancer treatment. A normal phase high-performance thin-layer chromatography (NP-HPTLC) method was developed and validated for the simultaneous profiling of Erlotinib and its Desethynyl Erlotinib impurity. The optimized method utilized ethyl acetate, methanol, and glacial acetic acid (9: 0.5: 0.5 v/v/v) as the mobile phase for effective separation and quantification. The method demonstrated excellent linearity for Erlotinib and its impurity over a concentration range of 200-1200 ng/spot, with R2 values of 0.9979 and 0.9998, respectively. Validation confirmed precision with intra-day and inter-day % RSD values of less than 2% and robustness. The “limits of detection (LOD) and quantification (LOQ)” were 5.18 ng/spot and 15.70 ng/spot for Erlotinib and 7.07 ng/spot and 21.43 ng/spot for the impurity. In-vitro assays against the A549 lung cancer cell line expressing wild-type EGFR tyrosine kinase (WT EGFR TK) showed that the Desethynyl Erlotinib impurity exhibits significant inhibition compared to Erlotinib, suggesting the potential toxicity of the Desethynyl Erlotinib impurity and causing side effects such as diarrhea, skin rashes and interstitial lung disease due to WT EGFR tyrosine kinase (WT EGFR TK) inhibition. Molecular docking and molecular dynamics simulations further corroborated greater stability in the Desethynyl Erlotinib impurity with WT EGFR tyrosine kinase (WT EGFR TK). Clinically, these findings highlight the importance of monitoring and minimizing impurities like Desethynyl Erlotinib to prevent adverse effects and maintain the therapeutic safety of Erlotinib in lung cancer treatment. This research underscores the necessity for rigorous quality control in Erlotinib production to ensure purity and therapeutic effectiveness.
Magneto-optical reflectivity of superconducting MgB2 single crystals
Creators: name: Perucchi, A.
name: Degiorgi, L.
name: Jun, J.
name: Angst, M.
name: Karpinski, J.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present magneto-optical reflectivity results in the basal-plane of the hexagonal $MgB_2$. The data were collected on a mosaic of $MgB_2$ single crystals with $T_{c}=38 ~K$ from the ultraviolet down to the far infrared as a function of temperature and magnetic field oriented along the c-axis. In the far infrared there is a clear signature of the superconducting gap with a gap-ratio $2Δ/k_{B}T_{c}\sim 1.2$, well below the weak-coupling value. The gap is suppressed in an external magnetic field, which is a function of temperature. We extract the upper critical field $H_{c2}$ along the c-axis. The temperature dependence of $H_{c2}$ is compatible with the Helfand-Werthamer behaviour.
description: 6 pages (3 text-pages, 3 figures), submitted to PRL
MOESM9 of Hidden biodiversity revealed by integrated morphology and genetic species delimitation of spring dwelling water mite species (Acari, Parasitengona: Hydrachnidia)
Creators: name: Blattner, Lucas
name: Gerecke, Reinhard
name: Fumetti, Stefanie
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 9: Figure S6. 28S RAxML-NG Maximum Likelihood tree with support values. Clades indicating more species than the a-priori morphospecies are marked in red.
Two-bridge knots admit no purely cosmetic surgeries
Creators: name: Ichihara, Kazuhiro
name: Jong, In Dae
name: Mattman, Thomas W.
name: Saito, Toshio
Publisher: name: arXiv
Year: 2019
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: Primary 57M27, Secondary 57M25

description: We show that two-bridge knots and alternating fibered knots admit no purely cosmetic surgeries, i.e., no pair of distinct Dehn surgeries on such a knot produce 3-manifolds that are homeomorphic as oriented manifolds. Our argument, based on a recent result by Hanselman, uses several invariants of knots or 3-manifolds; for knots, we study the signature and some finite type invariants, and for 3-manifolds, we deploy the $SL(2,\mathbb{C})$ Casson invariant.
description: 13 pages, 3 figures; minor errors in Figures 2, 3 are corrected in V2
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1 -mutated acute myeloid leukemia
Creators: name: Papaioannou, Dimitrios
name: Petri, Andreas
name: Dovey, Oliver M.
name: Terreri, Sara
name: Wang, Eric
name: Collins, Frances A.
name: Woodward, Lauren A.
name: Walker, Allison E.
name: Nicolet, Deedra
name: Pepe, Felice
name: Kumchala, Prasanthi
name: Bill, Marius
name: Walker, Christopher J.
name: Karunasiri, Malith
name: Mrózek, Krzysztof
name: Gardner, Miranda L.
name: Camilotto, Virginia
name: Zitzer, Nina
name: Cooper, Jonathan L.
name: Cai, Xiongwei
name: Rong-Mullins, Xiaoqing
name: Kohlschmidt, Jessica
name: Archer, Kellie J.
name: Freitas, Michael A.
name: Zheng, Yi
name: Lee, Robert J.
name: Aifantis, Iannis
name: Vassiliou, George
name: Singh, Guramrit
name: Kauppinen, Sakari
name: Bloomfield, Clara D.
name: Dorrance, Adrienne M.
name: Garzon, Ramiro
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/67
/631/337
/631/337/384
/631/337/572
/692/4017
/14/1
/38/22
/38/90
/38/91
/38/89
/38/109
/42/89
/45/15
/45/91
/45/88
article

description: Funder: U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)
description: Abstract: Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
Direct electrochemical determination of biotin by nano-modified electro-sensor in human blood serum
Creators: name: Smaeeli, Leili
name: Sadeghi, Soroor
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Biotin is the carboxylase coenzyme and high concentrations of free biotin in the blood are serious to immunodiagnostics. Developing a rapid, precise method for direct biotin detection in blood has been investigated based on the electrodeposition of zinc nanoparticles and 2-methyl benzimidazole on graphite electrodes by cyclic voltammetry. The square wave voltammetry has been used to consider the electroactive characteristics of this electro-sensor with 58.84 mm2 electrochemical surface area for irreversible electrooxidation of biotin with a diffusion coefficient equal to 5×10-4 cm2 s-1. The electron transfer coefficient was equal to 0.9, with an electron transfer rate of 2.83 s-1 and the saturated adsorption capacity was equal to 1.53×10-8 mol cm-2. Scanning electron microscopy revealed the nanostructure of electrodeposited layers. This sensor is capable of biotin determination over the 15 to 150 nmol L-1 range with a limit of detection of 5 nmol L-1 and a limit of quantification of 15 nmol L-1. The method’s reliability was checked regarding the spiked value of biotin from 20 to 80 nmol L-1 in blood serum samples. The low limit of detection, high accuracy and fast response with limited interferences confirm the sensor’s ability in biotin direct electrochemical monitoring in blood samples.
Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC
Creators: name: Potts, Nicola D.
name: Bichet, Coraline
name: Merat, Laurence
name: Guitton, Edouard
name: Krupa, Andrew P.
name: Burke, Terry A.
name: Kennedy, Lorna J.
name: Sorci, Gabriele
name: Kaufman, Jim
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Original Article
Avian
BLB1
BLB2
BF1
BF2
Recombination

description: Abstract: The classical class I and class II molecules of the major histocompatibility complex (MHC) play crucial roles in immune responses to infectious pathogens and vaccines as well as being important for autoimmunity, allergy, cancer and reproduction. These classical MHC genes are the most polymorphic known, with roughly 10,000 alleles in humans. In chickens, the MHC (also known as the BF-BL region) determines decisive resistance and susceptibility to infectious pathogens, but relatively few MHC alleles and haplotypes have been described in any detail. We describe a typing protocol for classical chicken class I (BF) and class II B (BLB) genes based on a hybridization method called reference strand-mediated conformational analysis (RSCA). We optimize the various steps, validate the analysis using well-characterized chicken MHC haplotypes, apply the system to type some experimental lines and discover a new chicken class I allele. This work establishes a basis for typing the MHC genes of chickens worldwide and provides an opportunity to correlate with microsatellite and with single nucleotide polymorphism (SNP) typing for approaches involving imputation.
Additional file 2 of Overexpression of DDX49 in prostate cancer is associated with poor prognosis
Creators: name: Tao, Junyue
name: Ge, Qintao
name: Meng, Jialing
name: Liang, Chaozhao
name: Hao, Zongyao
name: Zhou, Jun
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Table S2. The GO and KEGG enrichment results of DDX49 related genes.
Dynomene praedator A. Milne-Edwards 1879
Creators: name: Castro, Peter
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Dynomenidae
Dynomene
Dynomene praedator

description: Dynomene praedator A. Milne-Edwards, 1879
 Dynomene praedator A. Milne-Edwards, 1879b: 8, pl. 14, figs. 20–26 [type locality: New Caledonia, also from Samoa; lectotype: MNHN-B3991; paralectotypes: MNHN-B3991].
 Hawaiian Is. records:
 Dynomene praedator A. Milne-Edwards, 1879 — McLay 1999: 481, figs. 3b, 8a, b, 12d, 14b, 17b, 19 [Kaua‘i, O‘ahu]. — Guinot 2008: 15 (H.I.).
 Dynomene hispida Guérin, 1832 — Edmondson 1925: 30 (part) [O‘ahu, Kure Atoll]; 1946: 269, fig. 165 (part) [H.I.]. (not Dynomene hispida Guérin, 1832)
 Taxonomy. McLay (1999)
 Geographical distribution. Across Indo-West Pacific region.
 Habitat. Intertidal, shallow subtidal to 50 m.
description: Published as part of Castro, Peter, 2011, Catalog of the anomuran and brachyuran crabs (Crustacea: Decapoda: Anomura, Brachyura) of the Hawaiian Islands 2947, pp. 1-154 in Zootaxa 2947 (1) on page 34, DOI: 10.11646/zootaxa.2947.1.1, http://zenodo.org/record/5283044
NMR Investigation into the Influence of Surface Interactions on Liquid Diffusion in a Mesoporous Catalyst Support
Creators: name: Robinson, Neil
name: D’Agostino, Carmine
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Original Paper
NMR
Diffusion
Adsorption
Alcohols
Tortuosity

description: Abstract: Pulsed field gradient NMR diffusion measurements provide a non-invasive measure of the mass transport (self-diffusion) characteristics of liquids confined to porous catalyst materials. Here we explore the ability of this technique to probe the diffusive behaviour of a series of short-chain primary alcohols within a mesoporous catalyst support material; through the comparison of our results with highly surface-sensitive NMR relaxation data, we show that the evaluation of bulk-pore diffusion dynamics may provide a simple and indirect method to access and explore surface interaction phenomena occurring at the catalyst-liquid interface.
Orbital periods of twenty two subdwarf B stars
Creators: name: Morales-Rueda, L.
name: Maxted, P. F. L.
name: Marsh, T. R.
name: North, R. C.
name: Heber, U.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Subdwarf B (sdB) stars are thought to be core helium burning stars with low mass hydrogen envelopes. In recent years it has become clear that many sdB stars lose their hydrogen through interaction with a binary companion and continue to reside in binary systems today. In this paper we present the results of a programme to measure orbital parameters of binary sdB stars. We determine the orbits of 22 binary sdB stars from 424 radial velocity measurements, raising the sample of sdBs with known orbital parameters to 38. We calculate lower limits for the masses of the companions of the sdB stars which, when combined with the orbital periods of the systems, allow us to discuss approximate evolutionary constraints. We find that a formation path for sdB stars consisting of mass transfer at the tip of the red giant branch followed by a common envelope phase explains most, but not all of the observed systems. It is particularly difficult to explain both long period systems and short period, massive systems. We present new measurements of the effective temperature, surface density and surface helium abundance for some of the sdB stars by fitting their blue spectra. We find that two of them (PG0839+399 and KPD1946+4340) do not lie in the Extreme Horizontal Branch (EHB) band indicating that they are post-EHB stars.
description: 14 pages, 7 figures. Accepted by MNRAS
Additional file 17 of gCAnno: a graph-based single cell type annotation method
Creators: name: Yang, Xiaofei
name: Gao, Shenghan
name: Wang, Tingjie
name: Yang, Boyu
name: Dang, Ningxin
name: Ye, Kai
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 17: Figure S10. An example of the existence of selected cell type specific genes in liver ref. dropout test dataset. The red color in more than one type means these types shared this gene. With the increasing of dropout rate, the degree of shared specific genes increased a little, but the specific pattern is still strong even in dropout rate 50%.
title: Turbulence Suppression in an Axially Rotating Pipe
Creators: name: Smith, Alyn J.
Publisher: name: University of Kentucky Libraries
Year: 2021
Subjects: subject: FOS: Mechanical engineering

description: The phenomenon of turbulence suppression in a rotating pipe flow system has been well documented by past research and experimentation. Despite this, the methods that drive this phenomenon have not yet been effectively characterized, especially at higher Reynolds numbers. While many experiments have been performed to better understand swirling turbulent pipe flow, a difficulty that arises is how to test for high levels of rotation without reducing the Reynolds number. This thesis documents the design and construction of a new pressurized pipe flow system at the University of Kentucky aimed at achieving high Reynolds numbers without causing a reduction in rotation number. The facility has been designed to allow for particle imaging velocimetry experiments to be conducted at multiple length throughout a developing rotating pipe flow. This thesis also documents an experiment carried out on this new apparatus to confirm functionality and to determine the relationship between friction factor reduction, rotation number, and Reynolds number in a rotating turbulent pipe flow. This experiment found that the friction factor within the system decreased as rotation number increased in a manner independent of Reynolds number. Finally, recommendations are made on future improvements to the facility and future experimentation.
description: © 2021 Alyn J. Smith
Impact of the Hall effect in star formation : improving the angular momentum conservation
Creators: name: Marchand, Pierre
name: Tomida, Kengo
name: Commerçon, Benoît
name: Chabrier, Gilles
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present here a minor modification of our numerical implementation of the Hall effect for the 2D Riemann solver used in Constrained Transport schemes, as described in Marchand et al. (2018). In the previous work, the tests showed that the angular momentum was not conserved during protostellar collapse simulations, with significant impact. By removing the whistler waves speed from the characteristic speeds of non-magnetic variables in the 1D Riemann solver, we are able to improve the angular momentum conservation in our test-case by one order of magnitude, while keeping the second-order numerical convergence of the scheme. We also reproduce the simulations of Tsukamoto et al. (2015) with consistent resistivities, the three non-ideal MHD effects and initial rotation, and agree with their results. In this case, the violation of angular momentum conservation is negligible in regard to the total angular momentum and the angular momentum of the disk.
description: 6 pages, 6 figures, published in A&A
Expression and bioactivity analysis of TNF30, a TNFα nanobody, in Escherichia coli
Creators: name: Li, Qian
name: Miao, Zhi
name: Luo, Xue-Gang
name: Zhao, Jian
name: Song, Ya-Jian
name: Li, Zhong-Yuan
name: Zhou, Hao
name: Zhang, Tong-Cun
name: Mao, Li-Song
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Antibodies and antagonists targeting tumour necrosis factor alpha (TNFα) have become a number of the best-selling anti-inflammatory drugs. The nanobody is a single domain antibody derived from the variable domain of a heavy-chain antibody. However, so far, there are still no reports on the recombinant expression of TNFα nanobodies. Here, TNF30, the key anti-TNFα nanobody domain of ozoralizumab, was cloned, expressed in Escherichia coli, and then purified with the Ni2+-chelating affinity chromatography. The western blot results showed that the recombinant TNF30 has strong binding capability with TNFα. Furtermore, the pharmacological and histopathological analysis in the carrageenan-induced mice paw oedema demonstrated that the recombinant nanobodies had potential anti-inflammatory activity in vivo. These works provided a novel approach for the production of TNF30 in E. coli, and might establish a foundation for the industrial production of the drug and the development of more active derivatives against TNFα in the future.
Independent State and Measurement Characterization for Quantum Computers
Creators: name: Lin, Junan
name: Wallman, Joel J.
name: Hincks, Ian
name: Laflamme, Raymond
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Correctly characterizing state preparation and measurement (SPAM) processes is a necessary step towards building reliable quantum processing units (QPUs). In this work, we discuss the subtleties behind separately measuring SPAM errors. We propose a protocol that can separately estimate SPAM errors, in the case where quantum gates are ideal. In the case where the quantum gates are imperfect, we derive bounds on the estimated SPAM error rates, based on gate error measures which can be estimated independently of SPAM processes. Our method shows that the gauge ambiguity in characterizing SPAM operations can be resolved, by assuming that there exists one qubit whose initial state is uncorrelated with other qubits in a QPU. We test the protocol on a publicly available five-qubit QPU and demonstrate its validity by comparing our results with simulations.
description: 12 pages, 4 figures. Accepted journal version. Expanded with clearer formatting, more detailed calculations in the appendix, new data with a different presentation, and computer simulations
MOESM8 of Hidden biodiversity revealed by integrated morphology and genetic species delimitation of spring dwelling water mite species (Acari, Parasitengona: Hydrachnidia)
Creators: name: Blattner, Lucas
name: Gerecke, Reinhard
name: Fumetti, Stefanie
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 8: Figure S5. cox1 RAxML-NG Maximum Likelihood tree with support values. Clades indicating more species than the a-priori morphospecies are marked in red.
title: 03_0329
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils
Creators: name: Kwon, Young Mi
name: Gori, Kevin
name: Park, Naomi
name: Potts, Nicole
name: Swift, Kate
name: Wang, Jinhong
name: Stammnitz, Maximilian R.
name: Cannell, Naomi
name: Baez-Ortega, Adrian
name: Comte, Sebastien
name: Fox, Samantha
name: Harmsen, Colette
name: Huxtable, Stewart
name: Jones, Menna
name: Kreiss, Alexandre
name: Lawrence, Clare
name: Lazenby, Billie
name: Peck, Sarah
name: Pye, Ruth
name: Woods, Gregory
name: Zimmermann, Mona
name: Wedge, David C.
name: Pemberton, David
name: Stratton, Michael R.
name: Hamede, Rodrigo
name: Murchison, Elizabeth P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Research Article
subject: Medicine and health sciences
subject: Biology and life sciences
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.
SUSY Dark Matter in the Universe- Theoretical Direct Detection Rates
Creators: name: Vergados, J. D.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Exotic dark matter together with the vacuum energy or cosmological constant seem to dominate in the Universe. An even higher density of such matter seems to be gravitationally trapped in the Galaxy. Thus its direct detection is central to particle physics and cosmology. Current supersymmetric models provide a natural dark matter candidate which is the lightest supersymmetric particle (LSP). Such models combined with fairly well understood physics like the quark substructure of the nucleon and the nuclear structure (form factor and/or spin response function), permit the evaluation of the event rate for LSP-nucleus elastic scattering. The thus obtained event rates are, however, very low or even undetectable. So it is imperative to exploit the modulation effect, i.e. the dependence of the event rate on the earth's annual motion. Also it is useful to consider the directional rate, i.e its dependence on the direction of the recoiling nucleus. In this paper we study such a modulation effect both in non directional and directional experiments. We calculate both the differential and the total rates using both isothermal, symmetric as well as only axially asymmetric, and non isothermal, due to caustic rings, velocity distributions. We find that in the symmetric case the modulation amplitude is small. The same is true for the case of caustic rings. The inclusion of asymmetry, with a realistic enhanced velocity dispersion in the galactocentric direction, yields an enhanced modulation effect, especially in directional experiments.
description: 17 LATEX pages, 1 table and 6 ps figures included
Superconductivity and Instabilities in the t-t' Hubbard Model
Creators: name: Wegner, F.
name: Hankevych, V.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present a stability analysis of the 2D t-t' Hubbard model on a square lattice for t' = -t/6. We find possible phases of the model (d-wave Pomeranchuk and superconducting states, band splitting, singlet and triplet flux phases), and study the interplay of them.
description: 4 pages, 2 figures, submitted to the proceedings of the International Conference on Strongly Correlated Electron Systems SCES'02 (10-13 July, 2002, Krakow, Poland)