cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Polychaete assemblages on non-encrusting infralittoral algae from the Chafarinas Islands (SW Mediterranean)
Creators: name: LÓPEZ, Eduardo
name: VIÉITEZ, José M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: The present study describes polychaete assemblages from the Chafarinas Islands (SW Mediterranean) and their
 relationships with different infralittoral communities of non-encrusting algae. Thirty-one samples were taken from the fol-
 lowing infralittoral algal communities: Photophilic Algae in Exposed Water (PEW), Photophilic Algae in Calm Water
 (PCW), Sciaphilic Algae in Calm Water (SCW), and Hemiphotophilic Algae (HP). A total of 177 polychaete species was
 recorded. Each assemblage was characterized by a set of constant and dominant species. Diversity (Shannon index) for this
 taxocoenosis in every assemblage was high, ranging from 3.23 to 4.04. Evenness (Pielou index) values were also high, ran-
 ging from 0.61 to 0.72. One-way ANOSIM (Analysis of similarities) and ordination analyses showed that  polychaete assem-
 blages inhabiting different algal communities differed slightly. They also exhibited an environmental gradient with PEW at
 one extreme and HP and SCW at the other. The gradient was also apparent in the study of diversity, evenness and trophic
 guilds of each assemblage, especially with respect to numbers of  filter-feeders.
Composite poly(L-lactic acid) - ceramic structures for fully degradable cranial implants
Creators: name: Grzeszczak, Ana
name: Åberg, Jonas
name: Persson, Cecilia
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: To surgically repair a bone defect in the skull, a cranioplasty might be necessary. This procedure currently carries a high complication rate (7-20%). This rate is reduced to 2% when using cranial implants composed of a titanium mesh and specific calcium phosphate ceramic tiles. However, unlike the ceramic, which allows for partial replacement of the implant by the patient’s own bone, titanium is non-resorbable, interferes with follow-up imaging techniques, is a potential site for bacterial attachment, and its use in young, growing patients presupposes revision surgeries. Poly(L-lactic acid) (PLLA) is biocompatible, 3D-printable, and was evaluated as a potential resorbable material to replace the Ti structure. In this study, ceramic and PLLA composite structures were tested as a starting point for developing the best possible material for a suitable and non-harmful degradation process. Samples were designed as a beam of PLLA manufactured by fused deposition modeling (FDM) on a Prusa i3 MK3S+ (Prusa Research a.s., Prague, Czech Republic), embedded in a self-setting ceramic made of beta-tricalcium phosphate (Sigma-Aldrich, Missouri, USA), monocalcium phosphate monohydrate (Scharlau, Scharlab S.L., Sentmenat, Spain), and 0.5M citric acid solution. Scanning electron micrographs of cross-sections (InLens detector, 3kV accelerating voltage, Zeiss 1550 SEM, Carl Zeiss AG, Oberkochen, Germany) showed that the recesses in the polymer beam were well filled with ceramic. Retention of ceramic particles on the PLLA wall after peeling indicated that the two materials were well integrated. Mechanical tests were conducted by 4-point bending (ISO 5833, Shimadzu AGS-X, Shimadzu, Kyoto, Japan). The average bending modulus obtained was 2274±316MPa. The ceramic-only controls failed catastrophically at 115±10N, while the PLLA-ceramic composite structures remained structurally intact after an initial crack at 139±23N, and withstood the load until a final failure at 249±42N. The results indicated signs of adhesion between the two materials as well as some structural support provided by the PLLA structure to the molded ceramic. Further studies will be carried out on the behaviour of the material when immersed in degradation media.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
CC Chemokine Ligand 3 Overcomes the Bacteriocidal and Phagocytic Defect of Macrophages and Hastens Recovery from Experimental Otitis Media in TNF-/- Mice
Creators: name: Leichtle, Anke
name: Ryan, Allen F.
name: Radek, Katherine
name: Euteneuer, Sara
name: Wasserman, Stephen I.
name: Gallo, Richard
name: Lai, Yuping
name: Pak, Kwang
name: Yamasaki, Kenshi
name: Choung, Yun Hoon
name: Hernandez, Michelle
name: Ebmeyer, Joerg
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Innate immune mechanisms are crucial in defense against bacterial illnesses in humans, as evidenced by abnormal antibacterial responses due to defects in TLR signaling, seen in children with MyD88 or IL-1R–associated kinase 4 deficiency. Otitis media (OM) is the most common disease of childhood, and the role of innate immune molecules in this disorder remains unclear. In a murine model of OM, we show that, in the absence of TNF, a key effector of innate immunity, this disease is prolonged after middle ear infection with nontypeable Haemophilus influenzae (NTHi). In the absence of TNF, mice fail to upregulate both TLRs and downstream genes and proteins, such as CCL3, resulting in defects in both inflammatory cell recruitment and macrophage function. Peritoneal macrophages of mice lacking TNF have a diminished ability to phagocytose and kill NTHi, and this defect is partially corrected in vitro by exogenous rTNF. Addition of rCCL3 alone or in combination with rTNF restores phagocytosis and killing by TNF-deficient macrophages to that of unstimulated wild-type macrophages. In vivo administration of rCCL3 to animals deficient in TNF fully restores the ability to control OM due to NTHi, whereas a CCL3-blocking Ab impaired the ability of wild-type mice to recover from OM. Thus, CCL3 is a potent downstream effector of TNF-mediated inflammation in vitro and in vivo. Manipulation of CCL3 and/or TNF may prove to be effective therapeutic approaches in OM or other conditions associated with defective TNF generation.
(1833) William Love
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Solar energetic particle access to distant longitudes through turbulent field-line meandering
Creators: name: Laitinen, T.
name: Kopp, A.
name: Effenberger, F.
name: Dalla, S.
name: Marsh, M. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Context. Current solar energetic particle (SEP) propagation models describe the effects of interplanetary plasma turbulence on SEPs as diffusion, using a Fokker-Planck (FP) equation. However, FP models cannot explain the observed fast access of SEPs across the average magnetic field to regions that are widely separated in longitude within the heliosphere without using unrealistically strong cross-field diffusion. Aims. We study whether the recently suggested early non-diffusive phase of SEP propagation can explain the wide SEP events with realistic particle transport parameters. Methods. We used a novel model that accounts for the SEP propagation along field lines that meander as a result of plasma turbulence. Such a non-diffusive propagation mode has been shown to dominate the SEP cross-field propagation early in the SEP event history. We compare the new model to the traditional approach, and to SEP observations. Results. Using the new model, we reproduce the observed longitudinal extent of SEP peak fluxes that are characterised by a Gaussian profile with $σ=30-50^\circ$, while current diffusion theory can only explain extents of 11$^\circ$ with realistic diffusion coefficients. Our model also reproduces the timing of SEP arrival at distant longitudes, which cannot be explained using the diffusion model. Conclusions. The early onset of SEPs over a wide range of longitudes can be understood as a result of the effects of magnetic field-line random walk in the interplanetary medium and requires an SEP transport model that properly describes the non-diffusive early phase of SEP cross-field propagation.
description: 9 pages, 6 figures. Accepted for publication in Astronomy & Astrophysics
2.5D Melt printing of full spectrum medicinal Cannabis delivery microdepots
Creators: name: Uziel, Almog
name: Meiri, David
name: Lewitus, Dan
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: When a droplet of molten polymeric excipient/API (active pharmaceutical ingredient) mixture is deposited onto a superoleophobic surface, unlike conventional 3d printing, the surface is not wetted, resulting in the rapid production of discrete spherical molten droplets, that when solidify, near-perfect microspheres are generated (hence 2.5D). Microparticle-based polymeric depots are commonly applied toward the sustained release of drugs over prolonged periods, resulting, in reduction of the frequency of injecting drugs and improved pharmacokinetics. Thus, melt printing was evaluated as a solvent-free, cost-effective, and versatile technique to rapidly print microspheres of polymer melts using non-wetting surfaces with a specialized dispensing valve. Initially polycaprolactone?based microspheres with varying amounts of ibuprofen as a model drug were produced. In vitro release studies revealed that one can control the crystal characteristics of both the excipient and the API, resulting to tunable drug?release rates. To further evaluate the clinical prospect of melt printing as a prospect for API encapsulation, whole medicinal cannabis extract microspheres were prepared using anticonvulsant cannabis strand oil mixed with polycaprolactone. In vivo subcutaneous injections resulted in elevated serum levels of multiple, major and minor, phytocannabinoids for over 14 days, compared to Cannabis extract injection. An empirical model for the release kinetics of the phytocannabinoids as a function of their physical traits was developed, and their long-term efficacy was evaluated via a single administration of the microspheres compared to a single administration of Cannabis extract, in a pentylenetetrazol-induced convulsion model. One week following administration, the microspheres reduce the incidence of tonic-clonic seizures by 40%, increase the survival rate by 50%, and the latency to first tonic-clonic seizures by 170%. These results suggest that a long-term full-spectrum Cannabis delivery system from melt-printed microspheres may provide new form of Cannabis administration and treatments.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
Central Nervous System Destruction Mediated by Glutamic Acid Decarboxylase-Specific CD4+ T Cells
Creators: name: Workman, Creg J.
name: Eisenbarth, George S.
name: Vignali, Dario A.A.
name: Smeyne, Richard
name: Tisch, Roland
name: Baquet, Zachary
name: Burton, Amanda R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: High titers of autoantibodies against glutamic acid decarboxylase 65 (GAD65) are commonly observed in patients suffering from type 1 diabetes (T1D) as well as Stiff Person syndrome (SPS), a disorder that affects the central nervous system, and a variant of SPS, progressive encephalomyelitis with rigidity and myoclonus (PERM). While there is a considerable amount of data focusing on the role of GAD65-specific CD4+ T cells in T1D, little is known about their role in SPS. Here we show that mice possessing a monoclonal GAD65-specific CD4+ T cell population (4B5, PA19.9G11 or PA17.9G7) develop a lethal encephalomyelitis-like disease in the absence of any other T cells or B cells. GAD65-reactive CD4+ T cells were found throughout the CNS in direct concordance with GAD65 expression and activated microglia: proximal to the circumventricular organs at the interface between the brain parenchyma and the blood brain barrier. In the presence of B cells, high titer anti-GAD65 autoantibodies were generated but these had no effect on the incidence or severity of disease. In addition, GAD65-specific CD4+ T cells isolated from the brain were activated and produced IFN-γ. These findings suggest that GAD65-reactive CD4+ T cells alone mediate a lethal encephalomyelitis-like disease that may serve as a useful model to study GAD65-mediated diseases of the CNS.
Additional file 2 of Making change last? Exploring the value of sustainability approaches in healthcare: a scoping review
Creators: name: Lennox, L.
name: A. Linwood-Amor
name: L. Maher
name: J. Reed
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. PRISMA screening fillable checklist for scoping reviews.Docx. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist details the location of specific scoping review requirements.
Voices of Silence, Novelties of Noise: Oblivion and Hesitation as Origins of Quantum Mysteries
Creators: name: Cohen, Eliahu
name: Elitzur, Avshalom C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Among the (in)famous differences between classical and quantum mechanics, quantum counterfactuals seem to be the most intriguing. At the same time, they seem to underlie many quantum oddities. In this article, we propose a simple explanation for counterfactuals, on two levels. Quantum Oblivion (QO) is a fundamental type of quantum interaction that we prove to be the origin of quantum counterfactuals. It also turns out to underlie several well-known quantum effects. This phenomenon is discussed in the first part of the article, yielding some novel predictions. In the second part, a hypothesis is offered regarding the unique spacetime evolution underlying QO, termed Quantum Hesitation (QH). The hypothesis invokes advanced actions and interfering weak values, as derived first by the Two-State-Vector Formalism (TSVF). Here too, weak values are argued to underlie the familiar "strong" quantum values. With these, an event that appears to have never occurred can exert causal effects and then succumb to QO by another time-evolution involving negative weak values that eliminate them. We conclude with briefly discussing the implications of these ideas on the nature of time.
description: 15 pages, 5 figures. Submitted to J. Phys. Conf. Series (DICE2014 conference proceedings. Eds. H.-T. Elze et al.)
Земельная политика и землеустройство: международные перспективы
Creators: name: Магель Хольгер
name: Тиль Фабиан
name: Эспиноза Хорхе
Publisher: name: Международный сельскохозяйственный журнал
Year: 2017
Subjects: ГЛОБАЛЬНАЯ ЗЕМЕЛЬНАЯ ПОЛИТИКА
СУЩНОСТЬ ЗЕМЕЛЬНОГО МЕНЕДЖМЕНТА
КОМПЛЕКСНЫЙ ЗЕМЕЛЬНЫЙ МЕНЕДЖМЕНТ
СОЦИАЛЬНОЕ ЗЕМЕЛЬНОЕ ПРАВО
ПРАВО ЗЕМЛЕВЛАДЕНИЯ
GLOBAL LAND POLICY
THE ESSENCE OF THE LAND MANAGEMENT
INTEGRATED LAND MANAGEMENT
SOCIAL LAND LAW
LAND OWNERSHIP

description: Немецкая геодезия помимо традиционной деятельности, заключающейся в «топографической съемке и проекции» в духе Фридрика Роберта Хельмерта и добавившейся в последнее время области геоинформационных систем всегда включала в себя деятельность, связанную с планированием, обустройством, преобразованием и в конечном итоге переоформлением земельных угодий и обеспечением прав на земельную собственность. На фоне происходящих национальных и мировых процессов и требований лучших условий жизни (выживания), большей справедливости в отношении доступа к земле и устойчивого использования ограниченных земельных ресурсов исключительно большое значение приобретает основанное на геодезических системах координат и кадастрах понятие землеустройства (далее по тексту земельного менеджмента). В статье рассматриваются необходимость, история возникновения, теории, модели и направления земельного менеджмента.The German Geodesy in addition to the traditional activities of «topographical photography and projection» in the spirit of Robert Friedrich Helmert, and uses recently sphere of geoinformation systems, has always included activities related to planning, arrangement, transformation and eventual replacement of land and land ownership rights. Against the background of the developments of national and global processes and demands better living conditions (survival), greater equity in access to land and the sustainable use of limited land resources of great importance is based on the geodetic coordinate systems and cadastre the concept of land management. This article discusses the need for the emergence of land management, history, theory, models and guidelines.
Start the inclusive playground r-evolution: Identifying aspects to promote social inclusion
Creators: name: Wenger, Ines
name: Prellwitz, Maria
name: Schulze, Christina
Publisher: name: Zenodo
Year: 2022

description: The presentation was presented at the 18th WFOT Congress 2022 in Paris (WFOT International Congress 2022 (wfotcongress2022.org)). Abstract Introduction / Rationale: Through the design of inclusive playgrounds children with diverse needs should be enabled to participate in outdoor play. However, despite the presence of anti-discrimination policies in many European countries, there are only a few inclusive playgrounds. Furthermore, anti-discrimination policies often focus on the adaptation of the physical environment, which results in playgrounds being accessible, but not always inclusive or usable for play. Objectives: This project presents on qualitative research studies that explored the perceptions of playground builders and users in order to better understand how to improve social inclusion on inclusive playgrounds going beyond the adaptation of the physical environment. Method / Approach: Multiple methods were used (interviews, focus groups, observations) to explore the perceptions of playground builders (e.g. architects, landscape architects) and users (children with and without disabilities and their parents) in one area in Switzerland. The research was conducted within the P4PLAY Marie Skłodowska-Curie Innovative Training Network. Results and or Practice Implications: On one side findings identified the potential of listening to the children when designing for inclusion. On the other side challenges were identified on the individual, community and political level towards the evolution of social inclusion on inclusive playgrounds. A starting point to address these challenges on inclusive playgrounds may be a cooperation among playground planners/builders and users. Conclusion: The project identified several levels of action where occupational therapists could become actively involved for the evolution of social inclusion on inclusive playgrounds for children with diverse needs.
Cutting Edge: IFN-  Is a Negative Regulator of IL-23 in Murine Macrophages and Experimental Colitis
Creators: name: Matsuoka, Katsuyoshi
name: Rubinas, Tara
name: Kobayashi, Taku
name: Plevy, Scott E.
name: Li, Fengling
name: Sheikh, Shehzad Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: IL-23 regulation is a central event in the pathogenesis of the inflammatory bowel diseases. We demonstrate that IFN-γ has anti-inflammatory properties in the initiation phase of IL-23–mediated experimental colitis. IFN-γ attenuates LPS-mediated IL-23 expression in murine macrophages. Mechanistically, IFN-γ inhibits Il23a promoter activation through altering NF-κB binding and histone modification. Moreover, intestinal inflammation is inhibited by IFN-γ signaling through attenuation of Il23a gene expression. In germ-free wild-type mice colonized with enteric microbiota, inhibition of colonic Il23a temporally correlates with induction of IFN-γ. IFN-γR1/IL-10 double-deficient mice demonstrate markedly increased colonic inflammation and IL23a expression compared with those of IL-10−/− mice. Colonic CD11b+ cells are the primary source of IL-23 and a target for IFN-γ. This study describes an important anti-inflammatory role for IFN-γ through inhibition of IL-23. Converging genetic and functional findings suggest that IL-23 and IFN-γ are important pathogenic molecules in human inflammatory bowel disease.
Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity
Creators: name: Bertin, John
name: Schneider, Monika
name: Sutterwala, Fayyaz S.
name: Wilson, Justin E.
name: Moore, Chris B.
name: Gris, Denis
name: Allen, Irving C.
name: Lich, John D.
name: Ting, Jenny P.Y.
name: Arthur, Janelle C.
name: Koller, Beverly H.
name: Morrison, Amy
name: Liu, Zhi
name: O'Connor, Brian P.
name: Ye, Zhengmao
name: Roney, Kelly E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Nucleotide-binding domain leucine-rich repeat (NLR) proteins are regulators of inflammation and immunity. Although first described 8 y ago, a physiologic role for NLRP12 has remained elusive until now. We find that murine Nlrp12, an NLR linked to atopic dermatitis and hereditary periodic fever in humans, is prominently expressed in dendritic cells (DCs) and neutrophils. Nlrp12-deficient mice exhibit attenuated inflammatory responses in two models of contact hypersensitivity that exhibit features of allergic dermatitis. This cannot be attributed to defective Ag processing/presentation, inflammasome activation, or measurable changes in other inflammatory cytokines. Rather, Nlrp12(-/-) DCs display a significantly reduced capacity to migrate to draining lymph nodes. Both DCs and neutrophils fail to respond to chemokines in vitro. These findings indicate that NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state.
(1826) Philip Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Об оценке потребности растениеводческих хозяйств страны в растениепитателях-аппликаторах на основании роста востребованности жидких минеральных удобрений типа КАС в разрезе почвенно-климатических условий России
Creators: name: Фомин Александр
Publisher: name: Международный сельскохозяйственный журнал
Year: 2017
Subjects: РАСТЕНИЕПИТАТЕЛЬ
АППЛИКАТОР
КАС
ЖИДКИЕ МИНЕРАЛЬНЫЕ УДОБРЕНИЯ
ЛИСТОВЫЕ ПОДКОРМКИ
ВНУТРИПОЧВЕННОЕ ВНЕСЕНИЕ
ДЕФИЦИТ ВЛАГИ
PLANTFEEDER
APPLICATOR
UAN
LIQUID FERTILIZERS
FOLIAR APPLICATION
SOIL INCORPORATION
THE SOIL MOISTURE DEFICIT

description: Рассматриваются вопросы востребованности растениепитателей в аграрных хозяйствах России в разрезе наметившейся тенденции роста объемов применения жидких минеральных удобрений (ЖМУ), в частности КАС, с учетом проблем растениеводства в регионах с дефицитом влаги. На примерах продемонстрировано преимущество ЖМУ по сравнению с другими видами удобрений. Основная причина малой востребованности ЖМУ объективно недостаточная материально-техническая база. В большой части регионов России существуют показатели для применения ЖМУ, в том числе КАС, причем в ряде регионов их наибольшей эффективности можно добиться именно внутрипочвенным внесением. Проведенные исследования подтвердили, что существуют объективные предпосылки для повышения спроса на аппликаторы.Discusses issues of demand for plantfeeder in the agricultural farms in Russia in the context of emerging trends of growth in the application of liquid mineral fertilizers, in particular the CAS, taking into account the problems of crop production in regions with a moisture deficit. The examples demonstrated the advantage of liquid fertilizers compared to other fertilizers. The main reason for the low demand for GMU objectively insufficient material and technical base. In most of the regions of Russia there are indicators for the application of GMU, including CAS, and in some of their greatest efficiency you can achieve is the subsurface Deposit. Studies have confirmed that there are objective preconditions for increasing the demand for applicators.
Deletion of ripA Alleviates Suppression of the Inflammasome and MAPK by Francisella tularensis
Creators: name: Kijek, Todd M.
name: Wen, Haitao
name: Huang, Max Tze Han
name: Taxman, Debra J.
name: Ting, Jenny Pan Yun
name: Allen, Irving Coy
name: Craven, Robin R.
name: Davis, Beckley K.
name: Fuller, James R.
name: Brickey, Willie June
name: Gris, Denis
name: Mortensen, Brittany L.
name: Kawula, Thomas H.
name: Taft-Benz, Sharon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Francisella tularensis is a facultative intracellular pathogen and potential biothreat agent. Evasion of the immune response contributes to the extraordinary virulence of this organism although the mechanism is unclear. Whereas wild-type strains induced low levels of cytokines, an F. tularensis ripA deletion mutant (LVSΔripA) provoked significant release of IL-1β, IL-18, and TNF-α by resting macrophages. IL-1β and IL-18 secretion was dependent on inflammasome components pyrin-caspase recruitment domain/apoptotic speck-containing protein with a caspase recruitment domain and caspase-1, and the TLR/IL-1R signaling molecule MyD88 was required for inflammatory cytokine synthesis. Complementation of LVSΔripA with a plasmid encoding ripA restored immune evasion. Similar findings were observed in a human monocytic line. The presence of ripA nearly eliminated activation of MAPKs including ERK1/2, JNK, and p38, and pharmacologic inhibitors of these three MAPKs reduced cytokine induction by LVSΔripA. Animals infected with LVSΔripA mounted a stronger IL-1β and TNF-α response than that of mice infected with wild-type live vaccine strain. This analysis revealed novel immune evasive mechanisms of F. tularensis.
Уроки реформ Петра Аркадьевича Столыпина
Creators: name: Фомин Александр
Publisher: name: Международный сельскохозяйственный журнал
Year: 2017
Subjects: РЕФОРМЫ
АГРАРНЫЕ ПРЕОБРАЗОВАНИЯ
ЗЕМЛЕУСТРОЙСТВО
СТОЛЫПИН
ОБЩИНА
СЕЛЬСКОЕ ХОЗЯЙСТВО
СОБСТВЕННИКИ
АГРОНОМИЯ
СЕЛЬХОЗТЕХНИКА
КООПЕРАЦИЯ
REFORM
AGRARIAN TRANSFORMATION
LAND MANAGEMENT
STOLYPIN
COMMUNITY
AGRICULTURE
LANDOWNERS
AGRONOMY
AGRICULTURAL MACHINERY
COOPERATION

description: В данной научной статье рассмотрены история реформ председателя Правительства России Петра Аркадьевича Столыпина. Проведены исторические параллели с современными преобразованиями в экономике и социальной сфере страны. Отмечено, что нынешнее состояние, проблемы и приоритеты аграрных преобразований в современной России значительно проще, чем те условия, в которых пришлось проводить свои реформы Столыпину. Особое внимание уделено взаимодействию аграрной экономики, рынка и государства в начале ХХ века. Следует отметить, что трудности в сельском хозяйстве в значительной мере объясняются, как и более, чем 100 лет назад, так и в современных условиях, несовершенством аграрной политики, а также недооценкой значения и роли аграрного сектора в экономике страны. Особое внимание в статье уделено земельной реформе П.А. Столыпина, рассмотрены основные этапы и механизмы ее проведения. Несмотря на разницу в оценках последствий реформ, результаты, приведенные в статье, объективно отражают возросшую эффективность сельского хозяйства России.In this research article examines the history of reforms of Prime Minister Pyotr Arkadyevich Stolypin. Conducted historical Parallels with contemporary transformations in economy and social sphere of the country. Noted that the current status, problems and priorities of agrarian reforms in modern Russia are much simpler than those conditions which had to carry out his reforms Stolypin. Special attention is paid to interaction of agrarian Economics, market and state in the early twentieth century. It should be noted that the difficulties in agriculture to some extent be explained as more than 100 years ago, and in modern conditions, imperfection of agrarian policy and underestimation of the importance and role of the agricultural sector in the economy. Special attention is paid to land reform P.A. Stolypin, the basic stages and mechanisms of its implementation. Despite the difference in the estimates of effects of reforms, the results given in the article, objectively reflect the increased efficiency of agriculture of Russia.
Additional file 7 of Cross-protection against homo and heterologous influenza viruses via intranasal administration of an HA chimeric multiepitope nanoparticle vaccine
Creators: name: Zhao, Yongqiang
name: Liu, Jia
name: Peng, Chun
name: Guo, Shuangshuang
name: Wang, Bo
name: Chen, Longping
name: Wang, Yating
name: Tang, Haiwen
name: Liu, Liming
name: Pan, Qi
name: Li, Shiren
name: Wang, Jingyu
name: Yang, Dongni
name: Du, Enqi
Publisher: name: figshare
Year: 2025
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 7: Additional file 7: table S1 Histopathological scoring of lungs on Day 5 postinfection. (a) Definition of the grading of five scoring systems. (b) Histopathological scoring of lungs.
(1827) Kate Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Increased Hematopoietic Cells in the mertk-/- Mouse Peritoneal Cavity: A Result of Augmented Migration
Creators: name: Williams, Julie C.
name: Matsushima, Glenn K.
name: Earp, H. Shelton
name: Wagner, Nikki J.
name: Vilen, Barbara J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The peritoneal cavity is recognized as an important site for autoreactive B cells prior to their transit to other immune tissues; however, little is known of the genes that may regulate this process. Mice lacking the receptor tyrosine kinase Mertk display a lupus-like autoimmune phenotype with splenomegaly and high autoantibodies titers. Here, we investigate whether Mertk regulates the composition of peritoneal cells that favor an autoimmune phenotype. We found an increase in the number of macrophages, DC, plasmacytoid DC, T cells and B cells in the peritoneal cavity of mertk−/− mice when compared to wild-type mice. This disparity in cell numbers was not due to changes in cell proliferation or cell death. In adoptive transfer experiments, we showed an increase in migration of labeled donor cells into the mertk−/− peritoneal cavity. In addition, bone marrow chimeric mice showed hematopoietic-derived factors were also critical for T cell migration. Consistent with this migration and the increase in the number of cells, we identified elevated expression of CXCL9, its receptor CXCR3, and IL-7 receptor on peritoneal cells from mertk−/− mice. To corroborate the migratory function of CXCR3 on cells, the depletion of CXCR3 donor cells significantly reduced the number of adoptively transferred cells that entered into the peritoneum of mertk−/− mice. This control of peritoneal cells numbers correlated with autoantibody production and was exclusively attributed to Mertk since mice lacking other family members, Axl or Tyro 3, did not display dysregulation in peritoneal cell numbers or the autoimmune phenotype.
Robust gapless surface state and Rashba-splitting bands upon surface deposition of magnetic Cr on Bi$_2$Se$_3$
Creators: name: Wang, Eryin
name: Tang, Peizhe
name: Wan, Guoliang
name: Fedorov, Alexei V.
name: Miotkowski, Ireneusz
name: Chen, Yong P.
name: Duan, Wenhui
name: Zhou, Shuyun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The interaction between magnetic impurities and the gapless surface state is of critical importance for realizing novel quantum phenomena and new functionalities in topological insulators. By combining angle-resolved photoemission spectroscopic experiments with density functional theory calculations, we show that surface deposition of Cr atoms on Bi$_2$Se$_3$ does not lead to gap opening of the surface state at the Dirac point, indicating the absence of long-range out-of-plane ferromagnetism down to our measurement temperature of 15 K. This is in sharp contrast to bulk Cr doping, and the origin is attributed to different Cr occupation sites. These results highlight the importance of nanoscale configuration of doped magnetic impurities in determining the electronic and magnetic properties of topological insulators.
description: Nano Letter, DOI: 10.1021/nl504900s
Основные понятия экономической эффективности управления устойчивым землепользованием
Creators: name: Рассказова Анна
name: Жданова Руслана
Publisher: name: Международный сельскохозяйственный журнал
Year: 2017
Subjects: ЭФФЕКТ
ЭФФЕКТИВНОСТЬ
ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ
ЭКОНОМИЧЕСКИЙ ЭФФЕКТ
РЕЗУЛЬТАТ
ЗЕМЛЕПОЛЬЗОВАНИЕ
ЗАТРАТЫ
ДОХОДЫ
EFFECT
EFFECTIVENESS
ECONOMIC EFFICIENCY
ECONOMIC EFFECT
RESULT
LAND
COSTS
PROFITS

description: Авторами рассмотрены теоретические положения эффективности и эффекта устойчивого землепользования, а именно дано определение, классификация, проанализировано мнение различных экономистов по этому вопросу. Кроме того, сформулировано определение экономического эффекта и эффективности устойчивого землепользования с выделением основных принципов и видов.The authors considered the theoretical principles of effectiveness and impact of sustainable land use, namely the definition, classification, and analyzed the opinion of various economists on the issue. Additionally, the definition of economic effect and effectiveness of sustainable land use, highlighting the main principles and types.
MÂCHOIRES ET GLANDES ANNEXES DE GLYCERA CONVOLUTA (KEFERSTEIN), ANNÉLIDE POLYCHÈTE GLYCERIDAE
Creators: name: MICHEL, Catherine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: Glycera convoluta (Keferstein) is a carnivorous predatory Polychaetous Annelid which grasps its preys with the help of its four jaws situated at the end of the devaginated proboscis. These jaws are run through their length by a fine duct connected with the annexed glands, allowing the injection of the glandulary
secretion to preys. This secretion would be poisonous, working as a neurotoxic substance on some Invertebrates, particularly on Crustaceans.
title: Analysing and controlling the self-assembly of Gelation
Creators: name: Cross, Emily Ruth
Publisher: name: University of Glasgow
Year: 2020
Subjects: subject: gelation, gel, hydrogel, electrochemical fabrication, multicomponent, electrochemistry.

description: We describe new methods to analyse and control the self-assembly of gelation leading to exciting new soft materials. These materials have been shown to be of use to a wide range of applications including antimicrobial coatings, OPV devices, thermochromic materials and biomedical materials. Many of the described methods are novel or go beyond the state of the art. One of the analytical methods probes the surface chemistry of self-assembled hydrogel fibres to determine their pKa. This method not only determines the gel’s pKa but whether indeed a gel would form from a small molecule and what its rheological stiffness would be. This is the first incident of electrochemistry being used to determine the rheology of gels. Furthermore, a method to probe in the real time the self-assembly kinetics of a gelator to form a gel using multiple pulse amperometry is described. This method is expanded to complex multicomponent systems. Electrochemically fabricated hydrogels are developed and for the first time we show how the rheological properties can be controlled by controlling the electrochemical parameters. In addition to controlled rheological properties, the gels formed have unique mesh sizes and thermochromic properties. We introduce a new gelation trigger method for low molecular weight hydrogels. Dopamine autoxidation can be used to control the self-assembly of small molecules to form gels and we go on to describe how these gels can be used for antimicrobial purposes. To expand on the electrochemically fabricated hydrogels, we propose the oxidation of dopamine as a new electrochemical trigger. We describe how the rheological properties of the gels can be controlled and how they are potentially suitable for biomedical applications. Finally, we describe a method to control the self-assembly of both single and multi-component gel networks by temperature and use an array of analytical techniques to show this. We expand on this work to show how the temperature control can form gels with varying networks which lead directly to changes in the efficiency of electron transfer.
An insight into biological significance of marine cyanobacterial toxins in the recent decade
Creators: name: MARUTHANAYAGAM, Veerabadhran
name: NAGARAJAN, Manivel
name: SUNDARARAMAN, Muthuraman
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Marine cyanobacteria are the prolific and under-exploited sources of bioactive metabolites. Recently, metabolites have witnessed a wide range of exploration with well-known biological activities even at micro- and nano-molar concentrations and are chemically diverse in nature of the compounds. Hence, this review discusses and explores pharmacological and toxicological potentials of marine cyanobacterial metabolites comprehensively. Toxins from marine cyanobacteria have been broadly classified as hepatotoxin, neurotoxin and cytotoxin. Apart from these, some of the pharmacologically active metabolites, such as viridamides, lagunamides, coibamide, largazole and molassamide, showed activity against pathogenic microorganisms, cancer cell lines and protease enzyme inhibition. Apratoxin A and curacin A are potentially inhibiting secretary pathways and tubulin inhibiting agents respectively. They have been elucidated for the bioactive properties and structural analogues of them were also synthesized in vitro. In addition, some of the marine cyanobacterial metabolites identified, such as dolastatins, aurilide B, aurilide C, lyngbyastatins, lyngbyabellins and symplostatins, were found to be strong microtubule disruptors, cytotoxins, actin disruptors, either analogues or partial analogues of previously reported metabolites from marine organisms (molluscs, algae and sponges). Besides, fewer marine cyanobacterial metabolites possessing potent pharmaceutical capabilities have been patented. Hence, there is a dire need to address the thrust of pharmaceutical applications of available marine cyanobacterial metabolites.
Additional file 3 of Making change last? Exploring the value of sustainability approaches in healthcare: a scoping review
Creators: name: Lennox, L.
name: A. Linwood-Amor
name: L. Maher
name: J. Reed
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 3. Quality assessment inclusion and exclusion of full text.docx Details on inclusions and exclusion of full text papers.
Influenza Virus-Specific Immunological Memory Is Enhanced by Repeated Social Defeat
Creators: name: Sheridan, John F.
name: Papenfuss, Tracey
name: Powell, Nicole D.
name: Hunzeker, John T.
name: Mays, Jacqueline W.
name: Padgettand, David A.
name: Karlsson, Erik A.
name: Bailey, Michael T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Immunological memory (MEM) development is affected by stress-induced neuroendocrine mediators. Current knowledge about how a behavioral interaction, such as social defeat, alters the development of adaptive immunity, and MEM is incomplete. In this study, the experience of social disruption stress (SDR) prior to a primary influenza viral infection enhanced the frequency and function of the T cell memory pool. Socially stressed mice had a significantly enlarged population of CD8+ T cells specific for the immunodominant NP366–74 epitope of A/PR/8/34 virus in lung and spleen tissues at 6–12 wk after primary infection (resting memory). Moreover, during resting memory, SDR-MEM mice responded with an enhanced footpad delayed-type hypersensitivity response, and more IFN-γ–producing CD4+ T cells were detected after ex vivo stimulation. When mice were rechallenged with A/PR/8/34 virus, SDR-MEM mice terminated viral gene expression significantly earlier than MEM mice and generated a greater DbNP366–74CD8+ T cell response in the lung parenchyma and airways. This enhancement was specific to the T cell response. SDR-MEM mice had significantly attenuated anti-influenza IgG titers during resting memory. Similar experiments in which mice were primed with X-31 influenza and challenged with A/PR/8/34 virus elicited similar enhancements in the splenic and lung airway Db NP366–74CD8+ T cell populations in SDR-MEM mice. This study demonstrates that the experience of repeated social defeat prior to a primary viral infection significantly enhances virus-specific memory via augmentation of memory T cell populations and suggests that social stressors should be carefully considered in the design and analysis of future studies on antiviral immunity.
Additional file 1 of Making change last? Exploring the value of sustainability approaches in healthcare: a scoping review
Creators: name: Lennox, L.
name: A. Linwood-Amor
name: L. Maher
name: J. Reed
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Sustainability approaches tracked in the literature.docx. Summarises the number of citations and full-text articles retrieved per approach.
(1828) Julia Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Direct Method for Calculating Temperature-Dependent Transport Properties
Creators: name: Liu, Yi
name: Yuan, Zhe
name: Wesselink, R. J. H.
name: Starikov, Anton A.
name: van Schilfgaarde, Mark
name: Kelly, Paul J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show how temperature-induced disorder can be combined in a direct way with first-principles scattering theory to study diffusive transport in real materials. Excellent (good) agreement with experiment is found for the resistivity of Cu, Pd, Pt (and Fe) when lattice (and spin) disorder are calculated from first principles. For Fe, the agreement with experiment is limited by how well the magnetization (of itinerant ferromagnets) can be calculated as a function of temperature. By introducing a simple Debye-like model of spin disorder parameterized to reproduce the experimental magnetization, the temperature dependence of the average resistivity, the anisotropic magnetoresistance and the spin polarization of a Ni$_{80}$Fe$_{20}$ alloy are calculated and found to be in good agreement with existing data. Extension of the method to complex, inhomogeneous materials as well as to the calculation of other finite-temperature physical properties within the adiabatic approximation is straightforward.
description: Accepted as a Rapid Communication in Physical Review B
Playspaces within playspaces: exploring children's experiences of play occupation within playgrounds
Creators: name: Wenger, Ines
name: Prellwitz, Maria
name: Schulze, Christina
name: Lynch, Helen
Publisher: name: Zenodo
Year: 2022

description: Presentation given at the Inaugural World Occupational Science Conference in Vancouver, 2022 (Home - Inaugural World Occupational Science Conference (ubc.ca)). ABSTRACT
 Public playgrounds located in the neighborhoods are one place where children with different backgrounds and needs can meet, play, socially interact and connect with each other. Children report that playgrounds are important places in their lives. As such, playgrounds could be seen as collective spaces in a community setting. However, little is known about specific playspaces in playgrounds, what children do in these places and what meaning they ascribe to these places. Thus, the presentation aims to explore children’s doings in different playspaces on playgrounds, and the meaning they associate with these places. The presentation is informed by systematic search and synthesis of qualitative evidence about playgrounds from diverse children’s perspective. The included literature is analyzed through an occupational science lens and place-attachment theory. The findings will illustrate the different occupations children do in different places on playgrounds, and the meanings the children associate with it. Furthermore, children’s doings in these places are described and explored in relation to social interactions. Looking at playspaces from a child's perspective often gives insight into a different understanding compared to an adult's perspective. Within an Occupational Science community few have looked at specific playspaces on playgrounds and explored children’s occupations in these places from a place-attachment perspective. Therefore, the findings will add to the knowledge of children’s occupations as they are shaped by environmental relationships on playgrounds.