cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Brain Computer Interfaces: New Opportunities for Children with Cerebral Palsy
Creators: name: Jadavji, Zeanna A
Publisher: name: Cumming School of Medicine
Year: 2020
Subjects: subject: Perinatal Stroke
subject: Cerebral Palsy
subject: Brain Computer Interface
subject: Rehabilitation
subject: Functional Electrical Stimulation
subject: Pediatrics
subject: Assistive Technology
subject: Locked in Syndrome
subject: Health Sciences--Medicine and Surgery

description: Cerebral palsy (CP) is the leading cause of neurological disability and affects millions of people globally. Children with severe hemiparetic cerebral palsy have few options for motor rehabilitation despite having the ability to harness the developing brain’s innate plasticity. Further disadvantaged are children with quadriplegic cerebral palsy with limited or absent communication but bright minds. This condition can be thought of similarly to locked in syndrome, where the individual is mentally capable but trapped inside their body. Brain computer interface (BCI) technology may have the potential to address the rehabilitation and assistive technology needs of these children. BCI can help children bypass their physical disabilities and use their minds to affect their environment. Unfortunately, this research has been severely neglected in pediatrics. We first explored whether children with hemiparetic CP after perinatal stroke could use a simple BCI system to complete basic tasks and found that they were able to 1) achieve BCI competency, 2) perform similarly to healthy controls. This was followed by a study exploring the feasibility and tolerability of BCI activated functional electrical stimulation in the same population. There were no serious adverse effects or drop outs and children achieved relatively high classification accuracies. In our third study, we established a novel BCI program for children with severe neurological disabilities. All but one child in our program were able to use the BCI for various different tasks (e.g. painting, playing computer games, communication). We conducted interviews with our participant’s families to understand the importance and impact of our program. All families expressed an interested in continued involvement and felt that the program gave their child new opportunities for independence and participation. Here we emphasize the need for BCI research in children with severe disability. From our results we see vast potential for these tools to positively impact the quality of life for this population but there is an evident gap between BCI technology development and clinician and user contribution. Integrating the lived experiences of children and their families into research can help inform BCI development and ensure that these systems best meet the needs of end users.
Understanding the under-ice accumulation and emission of carbon dioxide and methane in Arctic lakes surrounding Cambridge Bay (Ikaluktutiak), Nunavut.
Creators: name: Walker, Zoe L
Publisher: name: Arts
Year: 2023
Subjects: subject: Carbon Cycles
subject: Methane Accumulation
subject: Carbon Dioxide Accumulation
subject: Biogeochemistry
subject: Gas exchange.
subject: Geography
subject: Biology--Limnology
subject: Biogeochemistry

description: The accumulation and emission of carbon dioxide (CO2) and methane (CH4) from high-latitude lakes has been recognized as an important contributor to the global carbon cycle and global carbon budgets. Published studies focus on the open-water season, often excluding the ice-covered period and rarely include lakes from the Canadian high Arctic. The ice-covered period is a critical component of lake carbon budgets, as the gases that accumulate over the winter and emit during the spring thaw represent a substantial fraction of total lake emissions. In this study, we collected under-ice chemistry measurements, including dissolved gases, during the early spring from 50 lakes near Cambridge Bay (Ikaluktutiak), Nunavut. The variability in concentration was substantial for CO2 (8.32-132.68 mg L-1 ) and CH4 (0.0005-3.16 mg L-1). We found strong logarithmic relationships between dissolved oxygen (O2) and CH4 as well as dissolved organic carbon (DOC) and CO2. We theorized that depth of water is the primary control on both dissolved CO2 and CH4, through a fractional freezing process that occurs during ice growth, and the development of anoxic conditions in shallow lakes. Accordingly, the variability in emission potential was considerable for CO2 (200.87 – 4080.36 mmol m-2) and CH4 (0.10 – 132 mmol m-2). We found that both CH4 and CO2 emission potential did not have a normal distribution. For CH4, 62% of lakes in the dataset were responsible for only 6.9% of CH4 emissions (low emitters), while 4% of lakes represented 18.7% of CH4 emissions (high emitters). When the emission potential data was modelled, results showed 95% of accumulated CO2 was emitted to the atmosphere within 15 days of ice breakup, and within 10 days of breakup for CH4. This data shows the substantial accumulation that can occur over the ice-covered season as well as how rapidly emissions may occur at ice-breakup. The Arctic is currently experiencing the effects of climate change four times faster than the rest of the globe through a phenomenon known as Arctic Amplification. The ubiquitous nature of lakes across the Arctic furthers the need to study seasonally ice-covered lakes as their spatiotemporal variability is an important component of the global carbon cycle and global carbon budgets. As the Arctic continues to see changes in air temperature, precipitation, runoff, and permafrost distribution the contributions and subsequent changes to these lakes must also be considered.
Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
Creators: name: Lee, Sukyoung
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: ALS
subject: Gut microbiota
subject: FTD
subject: TDP43
subject: Biology--Neuroscience

description: Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) is a spectrum of neurodegenerative diseases characterized by the progressive loss of the motoneurons (typical of ALS), and cognitive dysfunction (characteristic of FTD). Studies have previously identified biological sex as an important determinant in the presentation and risk of ALS-FTD, but the mechanisms underlying sex differences in disease are poorly understood. Sexual dimorphism is also evident in a mutant human TAR DNA binding protein 43 (TDP43) mouse model of ALS-FTD, whereby males have a much shorter lifespan than females. Interestingly, these mice exhibit an abnormally enlarged gut, suggesting an involvement of the gut microbiota (i.e., the collective microorganisms such as bacteria, viruses, and fungi that populate the organ and regulate its physiology) in disease. Emerging studies suggest that gut microbiota is a key determinant of ALS disease. In humans, the microbiota composition varies significantly between males and females, suggesting that such variation may affect the male susceptibility to the disease. Using 16S sequencing, I found alterations in the gut microbiota of TDP43 mice: the abundance of beneficial bacteria species is reduced in the gut of the mice. The gut microbiota changes are sex- and age-dependent. Furthermore, there is a disparity in the disease onset and survival between the female non-breeder and female breeder mice that correlates with a higher abundance of pro-inflammatory bacteria in the gut of the latter. I then induced inflammation in female TDP43 non-breeders with a bacterial product derived from one of the bacterial species enriched in the short-lived female TDP43 breeder mice, namely lipopolysaccharides (LPS). I found that LPS treatment exacerbates motoneuron disease and shortens the lifespan of the mice in a manner reminiscent of the survival of female TDP43 breeders and male TPD43 mice. Taken together, my results suggest that neurodegeneration and survival of TDP43 mice are associated with gut microbiota dysbiosis in a sex-dependent manner. My findings also implicate gut inflammation in disease progression. My work provides novel and crucial insights into the role of gut microbiota in ALS-FTD with implications for future personalized therapeutic interventions in individuals suffering from these diseases.
On the iteration of weak wreath products
Creators: name: Böhm, Gabriella
Publisher: name: arXiv
Year: 2011
Subjects: subject: Category Theory (math.CT)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: Based on a study of the 2-category of weak distributive laws, we describe a method of iterating Street's weak wreath product construction. That is, for any 2-category K and for any non-negative integer n, we introduce 2-categories Wdl^{(n)}(K), of (n+1)-tuples of monads in K pairwise related by weak distributive laws obeying the Yang-Baxter equation. The first instance Wdl^{(0)}(K) coincides with Mnd(K), the usual 2-category of monads in K, and for other values of n, Wdl^{(n)}(K) contains Mnd^{n+1}(K) as a full 2-subcategory. For the local idempotent closure K^ of K, extending the multiplication of the 2-monad Mnd, we equip these 2-categories with n possible `weak wreath product' 2-functors Wdl^{(n)}(K^) --> Wdl^{(n-1)}(K^), such that all of their possible n-fold composites Wdl^{(n)}(K^) --> Wdl^{(0)}(K^) are equal; i.e. such that the weak wreath product is `associative'. Whenever idempotent 2-cells in K split, this leads to pseudofunctors Wdl^{(n)}(K) --> Wdl^{(n-1)}(K) obeying the associativity property up-to isomorphism. We present a practically important occurrence of an iterated weak wreath product: the algebra of observable quantities in an Ising type quantum spin chain where the spins take their values in a dual pair of finite weak Hopf algebras. We also construct a fully faithful embedding of Wdl^{(n)}(K^) into the 2-category of commutative n+1 dimensional cubes in Mnd(K^) (hence into the 2-category of commutative n+1 dimensional cubes in K whenever K has Eilenberg-Moore objects and its idempotent 2-cells split). Finally we give a sufficient and necessary condition on a monad in K^ to be isomorphic to an n-ary weak wreath product.
description: 28 pages, LaTeX source v2: Paragraph 2.4 added; references updated
Capture
Creators: name: Geleyn, Rebecca
Publisher: name: Arts
Year: 2021
Subjects: subject: fiction
subject: twenty-first-century novel
subject: animal studies
subject: zoos
subject: photography
subject: late capitalism
subject: race
subject: queerness
subject: representation
subject: Literature--Canadian (English)
subject: Literature
subject: Education--Language and Literature

description: Capture is a novel that explores human-animal relationships through the lens of artistic representation. Using free indirect discourse and three alternating points of view, the manuscript follows a wedding photographer, Ros, her husband, Bernard, and her best friend, Sarah, who become entangled in a love triangle after Bernard leaves Calgary to join a multi-level marketing company. Ros, once beholden to the concept of love that kept her engaged in her work, becomes increasingly preoccupied with zoo animals as subjects for her photography; Sarah remembers being photographed in art college while negotiating romantic feelings for Ros; Bernard chases his life’s meaning but falls prey to devastating pro-capitalist doctrines. The novel uses ekphrasis as a mode of reflecting on images—mostly the ones Ros produces—of animals as well as human subjects. The dynamics of looking pervade the narrative, since the zoo, one of the novel’s central settings, is a place that encourages visitors to interact with animals as either “the objects of our ever-extending knowledge” (Berger 257) or the fantasy of an exotic spectatorial experience (Malamud). The dissertation considers how this setting, photography, and fiction frame animal subjects through processes of signification while interrogating the kinds of relationships that might follow from this framing.The critical afterword looks at Capture’s place as a polyvocal realist novel in the twenty-first century, arguing that “post-postmodern” literature has a desire to ethically engage with alterity. It then brings together the work of animal studies critics including Donna Haraway, Jacques Derrida, and Cary Wolfe, zeroing in on questions of seeing and subjecthood in relation to the nonhuman. Connecting zoos to late capitalism, the afterword examines the rise of entrepreneurship and the haunting presence of money in the novel. It also attempts to forge a path between animal studies and race and queerness using Haraway’s posthumanist figure of the cyborg. Finally, the afterword considers Roland Barthes’ and Susan Sontag’s seminal texts on photography to suggest that a kind of ekphrastic writing might help represent animals not as allegorical “stand-ins for human beings” (Huggan and Tiffin 149) but as others worthy of attention, respect, and wonder.
Marcel Proust, Sentimenti filiali di un matricida
Creators: name: Ballerio, Stefano
Publisher: name: Università degli Studi di Milano
Year: 2011

description: Pubblicato sul «Figaro» dell’1 febbraio 1907 e poi nel volume dei Pastiches et melanges del 1919, Sentiments filiaux d’un parricide racconta la tragica fine di Henri van Blarenberghe, esponente dell’alta borghesia parigina e conoscente di Proust, che in un accesso di follia uccise la madre per poi suicidarsi. Si propongono una nuova traduzione italiana dell’articolo – con il finale che contro la volontà di Proust fu omesso nell’edizione sul «Figaro» e che non fu reintrodotto nella successiva edizione in volume – e un’introduzione che, raccogliendo alcuni spunti dell’articolo, tocca il tema della distinzione tra cronaca e finzione letteraria.
description: ENTHYMEMA, No 4 (2011)
The first RRN Conference. Redefinitions of the narrative sequence
Creators: name: Passalacqua, Franco
name: Pianzola, Federico
Publisher: name: Università degli Studi di Milano
Year: 2011

description: This is a brief report of the first conference organized in Fribourg (CH) by the Réseau Romand de Narratologie (RRN). The title of the conference was Redefinitons of the Sequence in Postclassical Narratology.
description: ENTHYMEMA, No 4 (2011)
Черниговский центр художественной металообработки Х века
Creators: name: Орлов, Руслан
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 430101
subject: Archaeological science

description: Орлов Р.С. Черниговский центр художественной металообработки Х века — Актуальные проблемы археологических исследований в Украинской ССР: Тезисы докладов республиканской конференции молодых ученых. Киев, апрель, 1981. - К., 1981, с.111Chernihiv Center for Artistic Metalworking of the 10th Century
Continuity and break points: some aspects of the contemporary debate in narrative theory
Creators: name: Passalacqua, Franco
name: Pianzola, Federico
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: narrative sequence, narratology, constructivism, proteus principle, event

description: This article presents some reflections on the concepts, terminology, and epistemological grounds of narrative theory. Our remarks are focused on the proposals advanced at the first RRN conference and they concern in particular two issues: the theoretical difference between classical and postclassical narratology and the paradigms of the contemporary debate. In the first part of the paper we focus on the definitional task of narrative theory; in the second part we describe the epistemology of and the theories built on two opposite paradigms: the mimetic and the constructivist. Our conclusions highlight the continuity and the break points between contemporary theories, soliciting narratologists to answer to the many questions raised.
description: ENTHYMEMA, No 4 (2011)
Influence of high permeability disks in an axisymmetric model of the Cadarache dynamo experiment
Creators: name: Giesecke, A.
name: Nore, C.
name: Stefani, F.
name: Gerbeth, G.
name: Léorat, J.
name: Herreman, W.
name: Luddens, F.
name: Guermond, J. -L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Numerical simulations of the kinematic induction equation are performed on a model configuration of the Cadarache von-Kármán-Sodium dynamo experiment. The effect of a localized axisymmetric distribution of relative permeability μ that represents soft iron material within the conducting fluid flow is investigated. The critical magnetic Reynolds number Rm^c for dynamo action of the first non-axisymmetric mode roughly scales like Rm^c(μ)-Rm^c(μ->infinity) ~ μ^(-1/2) i.e. the threshold decreases as μ increases. This scaling law suggests a skin effect mechanism in the soft iron disks. More important with regard to the Cadarache dynamo experiment, we observe a purely toroidal axisymmetric mode localized in the high permeability disks which becomes dominant for large μ. In this limit, the toroidal mode is close to the onset of dynamo action with a (negative) growth-rate that is rather independent of the magnetic Reynolds number. We qualitatively explain this effect by paramagnetic pumping at the fluid/disk interface and propose a simplified model that quantitatively reproduces numerical results. The crucial role of the high permeability disks for the mode selection in the Cadarache dynamo experiment cannot be inferred from computations using idealized pseudo-vacuum boundary conditions (H x n = 0).
description: 16 pages, 9 Figures, published in New Journal of Physics 14(2012), 053005
BOSHLANG'ICH SINF DARSLARIDA INNOVATSION PEDAGOGIK TEXNOLOGIYALARDAN SAMARALI FOYDALANISH USULLARI
Creators: name: Rashidova  Muxlisaxon Boxodirjon qizi Xorijiy tillar fakulteti  2-kurs talabasi
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada boshlang'ich sinf  darslarida innovatsion pedagogik texnologiyalardan samarali foydalanish metodikasi. Zamonaviy innovatsion pedagogik texnologiyalar ta'lim jarayonini mukkamal loyihalashtirishi, aniq masalalar qo'yish, rejalashtirilgan natijalarni amalga oshiruvchi uzviy bog'langan majmua hisoblanishi yoritib beriladi.O'qituvchilarni ta'lim tizimidagi innovatsion jarayonlarga va innovatsion faoliyatga tayyorlash haqida bayon etilgan.
Kalit so'zlar: kompyuter, axborot-kommunikatsiya, innovatsiya, interaktiv metod,
axborot texnologiyalar, mustaqil izlanish.
Аннотация:В данной статье представлена методика эффективного использования инновационных педагогических технологий на уроках начальной школы. Пояснено, что современные инновационные педагогические технологии рассматриваются как целостный комплекс, идеально проектирующий образовательный процесс, ставящий конкретные задачи и реализующий запланированные результаты. Поясняется подготовка педагогов к инновационным процессам и инновационной деятельности в системе образования.
Ключевые слова: компьютер, информационно-коммуникационные технологии, инновация, интерактивный метод, информационные технологии, самостоятельные исследования. 
Annotation: This article presents a methodology for the effective use of innovative pedagogical technologies in primary school lessons. It is explained that modern innovative pedagogical technologies are considered as an integral complex that ideally designs the educational process, sets specific tasks and implements planned results. The preparation of teachers for innovative processes and innovative activities in the education system is explained.
Key words: computer, information and communication technologies, innovation, interactive method, information technology, independent research
Microbial and Behavioural Responses to Long Life: Exploring Plasticity and Resiliency in Wild, White-Faced Capuchin Monkeys
Creators: name: Webb, Shasta E
Publisher: name: Arts
Year: 2022
Subjects: subject: Gut microbiome
subject: behaviour
subject: plasticity
subject: non-human primate
subject: flexibility
subject: host-microbe symbiosis
subject: Biology--Ecology
subject: Anthropology
subject: FOS: Sociology

description: Long-lived animals contend with challenges throughout their lives including shifting food and water availability, seasonal changes in temperature, precipitation, and plant phenology, fluctuating social landscapes, and changes in physiology and behaviour that accompany reproduction. How animals respond to these changes is influenced by their phenotypes, which can be plastic and variable across their life course. Two potential sources of plasticity include behaviour and the communities of microbes that inhabit the gastrointestinal tract, known as the gut microbiome. Using a well-characterized population of wild, long-lived non-human primates as a study system, I examined two aspects of plasticity: behavioural and gut microbiota shifts. I collected behavioural records, climate data, and fecal samples from a population of wild white-faced capuchin monkeys (Cebus imitator) inhabiting a dry tropical forest at Sector Santa Rosa in Costa Rica. In chapter 2, drawing on seven cumulative years of behavioural data from 214 individuals, I examined how behaviour diversity shifts at the group and individual level in association with dynamic ecological and demographic factors, with an emphasis on group size. Group size was a significant predictor of behavioural diversity, but ecological factors might constrain behavioural plasticity. In chapter 3, I combine three years of behavioural data with gut microbe 16S amplicon data to examine how activity budget and gut microbiota shift in response to reproductive states in 33 capuchin females. Reproductive state was a significant predictor of foraging behaviour, but gut microbial communities remained stable throughout reproduction. In chapter 4, using an extensive fecal sample dataset collected from 42 individuals over 4 years and a shotgun metagenomics sequencing approach, I examined how gut microbial communities shift in association with drought and seasonality. Periods of water scarcity, high temperatures, and available fruit biomass were significant predictors of gut microbial community structure, but functional capabilities of the gut microbiome remained stable in association with ecological variables. These projects provide a synthesis of how white-faced capuchins plastically respond to the challenges of demographic changes, reproduction, and environmental shifts. My research contributes to our understanding behavioural and gut microbial plasticity in a long-lived animal inhabiting a dynamic biome.
Intrigue artificielle, intrigue naturelle et schèmes cognitifs. Entretien avec Raphaël Baroni
Creators: name: Baroni, Raphaël
name: Passalacqua, Franco
name: Pianzola, Federico
Publisher: name: Università degli Studi di Milano
Year: 2011

description: Parmi les nombreux sujets du débat contemporain à propos de la théorie narrative et de la narratologie, deux paradigmes fondamentaux ont récemment été mis en évidence : le paradigme mimétique ou référentiel, et le paradigme anti-mimétique ou constructiviste. Les différences et les tensions apparues entre les deux portent encore une fois sur la conception du récit et de ses éléments : comment fait-on pour théoriser les relations entre fabula et sujet ? Quel rapport y a-t-il entre les éléments de la séquence, les effets de la narration et nos capacités cognitives ? Pour éclaircir ces problèmes, Raphaël Baroni répond à certaines questions fondamentales de la théorie narrative. L’auteur de La tension narrative et de L’œuvre du temps, discerne tout d’abord le plan sur lequel reposent les difficultés, à savoir la définition de « séquence » ou d’« intrigue ». Il esquisse, ensuite, une perspective théorique apte à surmonter de tels obstacles. En examinant les relations entre discordance narrative et virtualité du récit, il est finalement amené à concevoir le récit non seulement comme un acte interactif, mais aussi comme une forme de perturbation des normes ordinaires de la communication.
description: ENTHYMEMA, No 4 (2011)
Topological Representation of Geometric Theories
Creators: name: Forssell, Henrik
Publisher: name: arXiv
Year: 2011
Subjects: subject: Logic (math.LO)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 03G30, 18B25, 18C10, 18C50, 18F20

description: Using Butz and Moerdijk's topological groupoid representation of a topos with enough points, a `syntax-semantics' duality for geometric theories is constructed. The emphasis is on a logical presentation, starting with a description of the semantical topological groupoid of models and isomorphisms of a theory and a direct proof that this groupoid represents its classifying topos. Using this representation, a contravariant adjunction is constructed between theories and topological groupoids. The restriction of this adjunction yields a contravariant equivalence between theories with enough models and semantical groupoids. Technically a variant of the syntax-semantics duality constructed in [Awodey and Forssell, arXiv:1008.3145v1] for first-order logic, the construction here works for arbitrary geometric theories and uses a slice construction on the side of groupoids---reflecting the use of `indexed' models in the representation theorem---which in several respects simplifies the construction and allows for an intrinsic characterization of the semantic side.
description: 32 pages. This is the first pre-print version, the final revised version can be found at http://onlinelibrary.wiley.com/doi/10.1002/malq.201100080/abstract (posting of which is not allowed by Wiley). Changes in v2: updated comments
Towards the fast scrambling conjecture
Creators: name: Lashkari, Nima
name: Stanford, Douglas
name: Hastings, Matthew
name: Osborne, Tobias
name: Hayden, Patrick
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Many proposed quantum mechanical models of black holes include highly nonlocal interactions. The time required for thermalization to occur in such models should reflect the relaxation times associated with classical black holes in general relativity. Moreover, the time required for a particularly strong form of thermalization to occur, sometimes known as scrambling, determines the time scale on which black holes should start to release information. It has been conjectured that black holes scramble in a time logarithmic in their entropy, and that no system in nature can scramble faster. In this article, we address the conjecture from two directions. First, we exhibit two examples of systems that do indeed scramble in logarithmic time: Brownian quantum circuits and the antiferromagnetic Ising model on a sparse random graph. Unfortunately, both fail to be truly ideal fast scramblers for reasons we discuss. Second, we use Lieb-Robinson techniques to prove a logarithmic lower bound on the scrambling time of systems with finite norm terms in their Hamiltonian. The bound holds in spite of any nonlocal structure in the Hamiltonian, which might permit every degree of freedom to interact directly with every other one.
description: 34 pages. v2: typo corrected
Representations of CRH PVN neurons and their dynamics
Creators: name: Simone, Kathryn
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Neural representation
subject: Neural dynamics
subject: Calcium imaging
subject: Photometry
subject: Stress
subject: Biology--Neuroscience

description: The hypothalamus is a key site in the brain for processing and orchestrating behavioral responses to threats to survival. Its paraventricular nucleus (PVN) houses a cluster of corticotropin-releasing hormone (CRH) neurons that launch the hormonal cascade of the endocrine stress response. However, they also mediate numerous stress-related and apparently opposing behaviors: Depending on the context, CRH PVN neurons are required for escape from an advancing threat, self-directed and social behaviors after a stressful event, and driving avoidance to specific places. Dysfunction of the hypothalamic-pituitary-adrenocortical (HPA) axis, which is governed by CRH PVN neurons, has extensive links to mental health conditions such as depression, and so understanding this circuit is significant to human health. What are the rules governing what behavior is elicited depending on the context, and what is the precise role of CRH PVN neurons in defense? The features of the external world that are represented by CRH PVN neurons are investigated, towards elucidating the contribution of CRH PVN in coordinating and manipulating the dynamic streams of information processed by the brain that give rise to defensive behaviors. Calcium imaging, reflectance spectroscopy, optogenetics, and nuanced approaches to the analysis of behavior are all leveraged to identify these representations in CRH PVN neurons and assess their behavioral consequences. A subset of CRH PVN neurons are found to exhibit derivative-like responses to brief, aversive inputs. A mechanistic model for how this filtering might be achieved, that agrees with calcium-imaging data, is presented. A step change in ambient lighting is applied to characterize the neural and behavioral co-evolution to abrupt contextual change, which reveals correlations with features of spatial risk in the activity patterns of individual CRH PVN neurons, and a cluster of cells that remain persistently active in steady-bright lighting. Finally, a simple solution for the analysis of defensive behaviors is developed and applied to discern the behavioral effects of increasing inhibitory tone to PVN. Spatial risk representations may prove particularly fruitful for linking the disparate behavioral contributions of CRH PVN neurons, by providinga new conceptual framework.
Biodegradable Cryogels for Adsorption and Electrochemical Oxidation of Organic Dyes
Creators: name: Abuhatab, Saqr S
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Materials Science
subject: Cryogels
subject: Electrochemistry
subject: Adsorption.
subject: Engineering--Chemical

description: The supply of clean water is becoming one of the greatest challenges of the 21st century. Therefore, sustainable and cost-effective measures must be developed and implemented to reduce water scarcity and prevent contamination of our water systems. This work aims to develop novel, environmentally-friendly 3D structured adsorbents for the removal of dissolved organic pollutants from wastewater. This was achieved by developing hydrophobic cryogels composed of TEMPO-oxidized cellulose nanofibers (TOCN) and electrochemically exfoliated graphene (EEG). TOCN/EEG cryogels were hydrophobized by incorporating oleic acid (OA) into the precursor gels. The cryogels were synthesized by mixing the components at 50 °C and 300 rpm for one hour, followed by freeze-drying the gels. The effect of OA loading, TOCN/EEG weight ratios (1:1 and 1:2), and initial solids content were systematically investigated through microstructural and rheological characterization of the precursor gels, and the morphology and adsorption capacity of the derived cryogels. The optimum OA loading for the hydrophobization of TOCN (HTOCN) was found to be 5 wt.%, at which the strongest gel was obtained. The initial solids content and EEG loadings in the precursor gel alter the morphology and adsorption capacity of the derived cryogels. The maximum adsorption uptake was increased by 180% for the 1:1 HTOCN/EEG weight ratio when the initial solids content in the precursor gels was increased from 1 wt.% to 4 wt.% compared to only 70% rise when the solids content was increased from 1.5 wt.% to 6 wt.% for the 1:2 HTOCN/EEG cryogels. The drop in the adsorption capacity enhancement of the 1:2 HTOOCN/EEG cryogels was attributed to the higher extent of EEG sheets aggregation at higher EEG contents. The electrochemical regeneration studies confirmed the ability to oxidize the methylene blue adsorbed onto the cryogels with minimal changes in the cryogels’ adsorption capacities after multiple regeneration cycles. The cryogel made of 1:1 HTOCN/EEG with 1 wt.% solids content gel was tested for 18 adsorption-electrochemical regeneration cycles with no observable mass loss and retained adsorption capacity confirming the feasibility of the proposed approach for developing adsorbents with long-term stability.
title: evaluation by image of the meniscal roots: Pictorial Essay
Creators: name: ribeiro, jessica
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Image verification
subject: Education and training
subject: Imaging sequences
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-3D
subject: MR-Functional imaging
subject: CT
subject: Musculoskeletal system
subject: Bones
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The objective of the present iconographic essay is to demonstrate the diagnostic role of MRI with two-dimensional and three-dimensional techniques and of arthrotomography in the lesions of the meniscal roots. Typical and illustrative cases were...
Mapping the Metabolism of Coronavirus Infection: Insights from Cell Culture Metabolomics
Creators: name: Wildman, Spencer
Publisher: name: Science
Year: 2022
Subjects: subject: Biological Sciences
subject: Biology--Molecular
subject: Biology--Cell

description: Viruses are known to hijack host cell metabolism to create an environment conducive to replication; however, the precise biochemical underpinnings of this phenomenon are not well-understood in coronaviruses. In this thesis, I outline the viral isotopic metabolic assay (VIMA): an adaptable, high-throughput analytical method for quantifying a wide range of cellular metabolic responses to viral infection. In human coronavirus 229E infected MRC-5 lung cells, decreased desaturation of de novo synthesized fatty acids, increased anapleurotic TCA cycle flux from glutamate, and decreased ribose phosphates were observed. Next, I translate VIMA to a model of SARS-CoV-2 infected human lung epithelial cells, where I observe a phenotype of depleted ribose phosphates and increased purine salvage consistent with the demand for nucleotides during viral genome replication. These results have the potential to guide future research into the pentose phosphate pathway and purine salvage pathways as antiviral targets.
Vanishing Minors in the Neutrino Mass Matrix from Abelian Gauge Symmetries
Creators: name: Araki, Takeshi
name: Heeck, Julian
name: Kubo, Jisuke
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Augmenting the Standard Model by three right-handed neutrinos allows for an anomaly-free gauge group extension G_max = U(1)_(B-L) x U(1)_(L_e-L_mu) x U(1)_(L_mu-L_tau). While simple U(1) subgroups of G_max have already been discussed in the context of approximate flavor symmetries, we show how two-zero textures in the right-handed neutrino Majorana mass matrix can be enforced by the flavor symmetry, which is spontaneously broken very economically by singlet scalars. These zeros lead to two vanishing minors in the low-energy neutrino mass matrix after the seesaw mechanism. This study may provide a new testing ground for a zero-texture approach: the different classes of two-zero textures with almost identical neutrino oscillation phenomenology can in principle be distinguished by their different Z' interactions at colliders.
description: 12 pages; Extended and clarified discussion; comments on finetuning in the textures; matches published version
Microtubules immuno-labeled with Alexa 647 with widefield images sample 015 to 0
Creators: name: SINGH, Manish
Publisher: name: Zenodo
Year: 2021
Subjects: shareloc.xyz
shareloc.xyz:dataset
dstorm
u373
microtubules
alexa-647
indirect-immuno-labeling
alpha-tubulin
2d
em-ccd
thunderstorm
gluox
pfa+gluta
smlm

description: Open in Shareloc.XYZ

description: dSTORM images of microtubules with widefield images, Alpha-tubulin immuno-labeled with Alexa 647 in U373 cells, reconstructed by ThunderSTORM plugin (Uploaded via https://shareloc.xyz)
Defining transmedia narrative: problems and questions. Dialogue with Mary-Laure Ryan
Creators: name: Passalacqua, Franco
name: Pianzola, Federico
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: narrative sequence, narratology, transmedia narrative

description: In this interview Mary-Laure Ryan faces some problems that arise from her definition of «transmedia narrative». Can every semiotic system tell stories? How can we elaborate a definition of «narrative» which accounts both for cognitive and semantic aspects? How can we dispense with the syntactic level if we need a definition of «narrativity» that suits every semiotic system? Answering these questions, Ryan deals with other proposals developed around the same theoretical problems, and points out a thought-provoking argument against Meir Sternberg’s functionalist definition of narrative.
description: ENTHYMEMA, No 4 (2011)
title: Incidental adrenal lesions: how to manage them?
Creators: name: Santos, Sofia
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Neoplasia
subject: Endocrine disorders
subject: Imaging sequences
subject: Biopsy
subject: MR
subject: CT
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: ● To review the imaging features of adrenal lesions in both computed tomography (CT) and magnetic resonance (MR) that allow narrowing of their differential diagnosis. ● To summarize the appropriate management of adrenal incidentalomas based on...
Twistor Networks and Covariant Twisted Geometries
Creators: name: Livine, Etera R.
name: Speziale, Simone
name: Tambornino, Johannes
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the symplectic reduction of the phase space of two twistors to the cotangent bundle of the Lorentz group. We provide expressions for the Lorentz generators and group elements in terms of the spinors defining the twistors. We use this to define twistor networks as a graph carrying the phase space of two twistors on each edge. We also introduce simple twistor networks, which provide a classical version of the simple projected spin networks living on the boundary Hilbert space of EPRL/FK spin foam models. Finally, we give an expression for the Haar measure in terms of spinors.
description: 18 pages. v2: minor amendments and some typos corrected
Narrative closure and the functionalist approach to narrative. Dialogue with Eyal Segal
Creators: name: Passalacqua, Franco
name: Pianzola, Federico
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: functionalism, narrative closure, rhetoric, Sternberg

description: Eyal Segal argues for a functionalist approach to narrative studies. Commenting on his work on «narrative closure», he provides examples that show that the comprehension of texts’ endings is enriched by rhetorical analysis and inevitably misguided by mimetic approaches.
description: ENTHYMEMA, No 4 (2011)
Can Minor Merging Account for the Size Growth of Quiescent Galaxies? New Results from the CANDELS Survey
Creators: name: Newman, Andrew B.
name: Ellis, Richard S.
name: Bundy, Kevin
name: Treu, Tommaso
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The presence of extremely compact galaxies at z~2 and their subsequent growth in physical size has been the cause of much puzzlement. We revisit the question using deep infrared Wide Field Camera 3 data to probe the rest-frame optical structure of 935 host galaxies selected with 0.4 10^10.7 Msol using optical and near-infrared photometry in the UKIRT Ultra Deep Survey and GOODS-South fields of the CANDELS survey. At each redshift, the most compact sources are those with little or no star formation, and we find that the mean size of these systems grows by a factor of 3.5 +- 0.3 over this redshift interval. The new data are sufficiently deep to enable us to identify companions to these hosts whose stellar masses are ten times smaller, while still yielding suitably accurate photometric redshifts to define a likely physical association. By searching for faint companions around 404 quiescent hosts within a projected physical annulus 10 < R < 30 kpc/h, we estimate the minor merger rate over the redshift range 0.4 < z < 2. After correcting for contamination from projected pairs, we find that 13-18% of quiescent hosts have likely physical companions with stellar mass ratios of 0.1 or greater. Mergers of these companions will typically increase the host mass by 6+-2% per merger timescale. We estimate the minimum growth rate necessary to explain the declining abundance of compact galaxies. Using a simple model of merging motivated by recent numerical simulations, we then assess whether mergers of the faint companions with their hosts are sufficient to explain this minimal rate. We find that mergers with mass ratios > 0.1 may explain most of the size evolution observed at z >~ 1 if a relatively short merger timescale is assumed, but the rapid growth seen at higher redshift likely requires additional physical processes.
description: Accepted to ApJ. Updated following referee report, with expanded comparisons to published mass-size and pair fraction measurements (Figs. 4 and 9)
Ol'ga Slivickaja, Un ‘incontro ideale’: Lermontov e Tolstoj
Creators: name: Illarionova, Elizaveta
Publisher: name: Università degli Studi di Milano
Year: 2011

description: Il saggio indaga l’antropologia culturale in Un eroe del nostro tempo di Lermontov a confronto con i romanzi di Tolstoj. L’analisi della novella Maksim Maksimyč permette di scoprire nella contrapposizione di Pečorin e Maksim Maksimyč il tema del conflitto culturale tra un uomo eccezionale e un «uomo semplice» e, in una visione più ampia, tra l’intelligencija e il popolo. Tale conflitto, irrisolto nel romanzo di Lermontov ad eccezione del tema del fatalismo comune a tutti i personaggi, verrà sanato nella figura di Pierre Bezuchov di Guerra e pace. In conclusione, si riafferma il duplice ruolo di Lermontov come antesignano di Tolstoj ma anche artista autonomo dalle scelte artistiche non inferiori ma radicalmente diverse da quelle tolstoiane.
description: ENTHYMEMA, No 4 (2011)
ADDITIONAL DOCUMENTATION OLSK Small Laser V2
Creators: name: InMachines Ingrassia GmbH
Publisher: name: Zenodo
Year: 2023
Subjects: OLSK
Small Laser
Laser Cutter
V2
Version 2
Wiring Schematic
Bill of Material
BOM
Workbook
Process
README

description: Bill of Materials, Preparation and Post Processing, Workbook, Read Me, Operational Instructions and Wiring Schematics of OLSK Small Laser V2.
Towards a Realization of the Condensed-Matter/Gravity Correspondence in String Theory via Consistent Abelian Truncation
Creators: name: Mohammed, Asadig
name: Murugan, Jeff
name: Nastase, Horatiu
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present an embedding of the 3-dimensional relativistic Landau-Ginzburg model for condensed matter systems in an $\mathcal{N}=6$, $U(N)\times U(N)$ Chern-Simons-matter theory (the ABJM model) by consistently truncating the latter to an abelian effective field theory encoding the collective dynamics of ${\cal O}(N)$ of the ${\cal O}(N^2)$ modes. In fact, depending on the VEV on one of the ABJM scalars, a mass deformation parameter $μ$ and the Chern-Simons level number $k$, our abelianization prescription allows us to interpolate between the abelian Higgs model with its usual multi-vortex solutions and a $ϕ^4$ theory. We sketch a simple condensed matter model that reproduces all the salient features of the abelianization. In this context, the abelianization can be interpreted as giving a dimensional reduction from four dimensions.
description: 4 pages, revtex; reference added, typo corrected; added clarifying paragraphs at end of introduction and on pages 3-4. Version accepted to PRL
ADDITIONAL DOCUMENTATION OLSK Small Laser V2
Creators: name: InMachines Ingrassia GmbH
Publisher: name: Zenodo
Year: 2023
Subjects: OLSK
Small Laser
Laser Cutter
V2
Version 2
Wiring Schematic
Bill of Material
BOM
Workbook
Process
README

description: Bill of Materials, Preparation and Post Processing, Workbook, Read Me and Wiring Schematics of OLSK Small Laser V2.
Microtubules immuno-labeled with Alexa 647 with widefield images sample 015 to 019
Creators: name: SINGH, Manish
Publisher: name: Zenodo
Year: 2021
Subjects: shareloc.xyz
shareloc.xyz:dataset
dstorm
u373
microtubules
alexa-647
indirect-immuno-labeling
alpha-tubulin
2d
em-ccd
thunderstorm
gluox
pfa+gluta
smlm

description: Open in Shareloc.XYZ

description: dSTORM images of microtubules with widefield images, Alpha-tubulin immuno-labeled with Alexa 647 in U373 cells, reconstructed by ThunderSTORM plugin (Uploaded via https://shareloc.xyz)
title: Relation between fat deposits in body fat accumulation
Creators: name: Dias, Nuno
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Anatomy
subject: Cardiac
subject: Ultrasound
subject: Absorptiometry / Bone densitometry
subject: Echocardiography
subject: Experimental investigations
subject: Metabolic disorders
subject: Epidemiology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Currently, the world population is facing an epidemic of overweight, which leads to metabolic dysregulations. The uncontrolled accumulation of body fat is due to several known factors, like the high consumption associated with poor energy...