Additional file 3 of Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis
Creators: name: Sabela Rodríguez-Lorenzo
name: Francisco, David Miguel Ferreira
name: Vos, Ricardo
name: Hof, Bert Van Het
name: Rijnsburger, Merel
name: Schroten, Horst
name: Ishikawa, Hiroshi
name: Beaino, Wissam
name: Bruggmann, Rémy
name: Kooij, Gijs
name: Vries, Helga E. De
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 3: Supplementary Fig. 3 Altered concentration of ADM and PAI-1 peptides in the CSF of MS patients. a Correlation plot of ADM protein concentration with age in CSF samples (n = 53). Smoothing line is calculated with linear regression, and shadow area represents the confidence interval around the smooth line. b Age of CSF donors with MS (n = 27) or control (n = 26), used for ADM protein assessment. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Welch Two Sample t-test. c ADM protein concentration in the CSF of MS patients with high disability (high EDSS; n = 9) or low disability (low EDSS; n = 18), as measured by RIA. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Wilcoxon rank sum test with continuity correction. d Age of CSF donors with high disability (high EDSS; n = 9) or low disability (low EDSS; n = 18), used for ADM protein assessment. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Welch Two Sample t-test. e Correlation plot of PAI-1 protein concentration with age in CSF samples (n = 31). Smoothing line is calculated with linear regression, and shadow area represents the confidence interval around the smooth line. f Age of CSF donors with high disability (high EDSS; n = 9) or low disability (low EDSS; n = 7), used for PAI-1 protein assessment. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Welch Two Sample t-test. g Correlation plot of STC2 protein concentration with age in CSF samples (n = 37). Smoothing line is calculated with linear regression, and shadow area represents the confidence interval around the smooth line. h STC2 protein concentration in the CSF of MS patients with high disability (high EDSS; n = 7) or low disability (low EDSS; n = 8), as measured by ELISA. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Welch Two Sample t-test. i Age of CSF donors with high disability (high EDSS; n = 7) or low disability (low EDSS; n = 8), used for STC2 protein assessment. Results are displayed as median and interquartile ranges (IQR). Differences were tested by Welch Two Sample t-test.