cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thermoelectric Power of the YbT$_{2}$Zn$_{20}$ (T = Fe, Ru, Os, Ir, Rh, and Co) Heavy Fermions
Creators: name: Mun, E. D.
name: Jia, S.
name: Bud'ko, S. L.
name: Canfield, P. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The thermoelectric power, $S(T)$, of the heavy fermions YbT$_{2}$Zn$_{20}$ ($T$ = Fe, Ru, Os, Ir, Rh, and Co) has been measured to characterize their strong electronic correlations. A large, negative, local minimum in $S(T)$ with approximately -70 $μ$V/K is found for all compounds. From the observed local minimum, the energy scales associated with both the Kondo temperature and the crystalline electric field splitting are deduced and compared to previous specific heat measurements. At low temperatures, $S(T)$ follows a linear temperature dependence, $S(T)$ = $αT$, with an enhanced value of $α$ which is characteristic for a heavy fermion state. In the zero temperature limit, the enhanced $α$ value strongly correlates with the electronic specific heat coefficient, $C(T)/T$, due to the large density of states at the Fermi level.
Derivation and external validation of a clinical version of the German Diabetes Risk Score (GDRS) including measures of HbA1c
Creators: name: Mühlenbruch, Kristin
name: Paprott, Rebecca
name: Joost, Hans-Georg
name: Boeing, Heiner
name: Heidemann, Christin
name: Schulze, Matthias B.
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: HbA1c
subject: clinical practice
subject: risk assessment
subject: type 2 diabetes
subject: 610 Medizin und Gesundheit

description: Objective The German Diabetes Risk Score (GDRS) is a diabetes prediction model which only includes non-invasively measured risk factors. The aim of this study was to extend the original GDRS by hemoglobin A1c (HbA1c) and validate this clinical GDRS in the nationwide German National Health Interview and Examination Survey 1998 (GNHIES98) cohort. Research design and methods Extension of the GDRS was based on the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study with baseline assessment conducted between 1994 and 1998 (N=27 548, main age range 35–65 years). Cox regression was applied with the original GDRS and HbA1c as independent variables. The extended model was evaluated by discrimination (C-index (95% CI)), calibration (calibration plots and expected to observed (E:O) ratios (95% CI)), and reclassification (net reclassification improvement, NRI (95% CI)). For validation, data from the GNHIES98 cohort with baseline assessment conducted between 1997 and 1999 were used (N=3717, age range 18–79 years). Missing data were handled with multiple imputation. Results After 5 years of follow-up 593 incident cases of type 2 diabetes occurred in EPIC-Potsdam and 86 in the GNHIES98 cohort. In EPIC-Potsdam, the C-index for the clinical GDRS was 0.87 (0.81 to 0.92) and the overall NRI was 0.26 (0.21 to 0.30), with a stronger improvement among cases compared with non-cases (NRIcases: 0.24 (0.19 to 0.28); NRInon-cases: 0.02 (0.01 to 0.02)). Almost perfect calibration was observed with a slight tendency toward overestimation, which was also reflected by an E:O ratio of 1.07 (0.99 to 1.16). In the GNHIES98 cohort, discrimination was excellent with a C-index of 0.91 (0.88 to 0.94). After recalibration, the calibration plot showed underestimation of diabetes risk in the highest risk group, while the E:O ratio indicated overall perfect calibration (1.02 (0.83 to 1.26)). Conclusions The clinical GDRS provides the opportunity to apply the original GDRS as a first step in risk assessment, which can then be extended in clinical practice with HbA1c whenever it was measured.
A microscopic theory of gauge mediation
Creators: name: Hook, Anson
name: Torroba, Gonzalo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.
description: 24 pages, 2 figures, accepted to JHEP for publication
INSIGHT FROM AID-INDUCED DNA DAMAGE RESOLUTION: CELLULAR CONTEXT MATTERS
Creators: name: INCORVAIA, ELISABETTA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: When genome integrity is perturbed, surveillance and repair mechanisms are activated to restore genome integrity through high fidelity DNA repair. However, in some physiological situations, those mechanisms are channeled away from integrity towards mutations and recombinations. During the diversification of the immunoglobulin locus in B cells, Activation Induced Deaminase (AID) triggers the physiological introduction of mutations. The current work was based on the observation that upon simple lesion generation, AID-induced deamination of a cytosine to uracil, the resolution by the molecular mechanism of DNA repair can lead to different outcomes. This homeostatic outcome, error-free or error-prone, is governed by specific cellular context and processes associated with DNA. To uncover the regulation of the pathway choice an in vitro system, named in vitro resolution (IVR), was developed. In the 1st phase of the IVR, AID was targeted to a DNA plasmid for uracil lesion generation. In the 2nd phase, a cellular extract resolved the lesions via Base Excision Repair [BER, divided in short patch (SP)-BER or long patch (LP)-BER] or Mismatch Repair (MMR). The quantitative nature of the IVR provided a novel means to precisely quantitate the contribution of each single DNA repair pathway. This set-up allowed us to evaluate how different cellular environments influenced the choice. Cell origins presented quantitative differences in DNA repair kinetics: a) overall sensitivity, b) non-B cells activating non-canonical MMR first, c) B cells activating SP-BER first, and d) LP-BER is significantly activated only in B cells. To understand the possible molecular mechanisms, we analysed single components known to influence DNA repair, such as transcription, protein availability, and chromatin. Changing the DNA substrate to either prefer or avoid forming nucleosomes, we uncovered significant changes in AID deamination preference and in DNA repair pathway choice. DNA with nucleosome favourable base-stacking preferred LP-BER, while non-nucleosome stacked DNA preferred SP-BER and MMR. Overall our findings provide novel insight into the cellular context that can influence DNA repair. The use of B cells and cancer cell lines can recapitulate in vivo Ig locus diversification, and our findings have a direct bearing in understanding mechanisms of tumorigenesis.
Propagation of an Earth-directed coronal mass ejection in three dimensions
Creators: name: Byrne, Jason P.
name: Maloney, Shane A.
name: McAteer, R. T. James
name: Refojo, Jose M.
name: Gallagher, Peter T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Solar coronal mass ejections (CMEs) are the most significant drivers of adverse space weather at Earth, but the physics governing their propagation through the heliosphere is not well understood. While stereoscopic imaging of CMEs with the Solar Terrestrial Relations Observatory (STEREO) has provided some insight into their three-dimensional (3D) propagation, the mechanisms governing their evolution remain unclear due to difficulties in reconstructing their true 3D structure. Here we use a new elliptical tie-pointing technique to reconstruct a full CME front in 3D, enabling us to quantify its deflected trajectory from high latitudes along the ecliptic, and measure its increasing angular width and propagation from 2-46 solar radii (approximately 0.2 AU). Beyond 7 solar radii, we show that its motion is determined by an aerodynamic drag in the solar wind and, using our reconstruction as input for a 3D magnetohydrodynamic simulation, we determine an accurate arrival time at the Lagrangian L1 point near Earth.
description: 5 figures, 2 supplementary movies
title: PIERO DELLA FRANCESCA'S MISERICORDIA POLYPTYCH: ARTIST, PATRON, AND COMMUNITY
Creators: name: Irani, Sarah Michelle Hempel
Publisher: name: Maryland Shared Open Access Repository
Year: 2011

description: In 1548, Monsignor Zanobio de' Medici traveled to the chapel of the Misericordia in the small Tuscan village of Sansepolcro. He marveled at a remarkable century-old altarpiece, with images of the Madonna and other saints before the high altar (Fig. 1). At the time of his visit, he stated that the panel was painted by the hand of Piero Franceschi, otherwise known as della Francesca, a resident of Sansepolcro. Piero della Francesca had been hired by one of the most powerful confraternities iii Sansepolcro of the time, nearly one hundred years prior to the Monsignor's visit, in 1445. Piero painted the altarpiece nearly a hundred years after the Black Death decimated the population of Italy in 1348, which was also about the same time that the confraternity was established within Sansepolcro. The confraternity of the Misericordia, as it was called, was a charitable organization that emerged after the Black Death swept through the Italian peninsula during the mid-fourteenth century. The members would tend to the sick, bury the dead, and engage in anonymous acts of charity.
Quantum theory of the charge stability diagram of semiconductor double quantum dot systems
Creators: name: Wang, Xin
name: Yang, Shuo
name: Sarma, S. Das
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We complete our recently introduced theoretical framework treating the double quantum dot system with a generalized form of Hubbard model. The effects of all quantum parameters involved in our model on the charge stability diagram are discussed in detail. A general formulation of the microscopic theory is presented, and truncating at one orbital per site, we study the implication of different choices of the model confinement potential on the Hubbard parameters as well as the charge stability diagram. We calculate the charge stability diagram keeping three orbitals per site and find that the effect of additional higher-lying orbitals on the subspace with lowest-energy orbitals only can be regarded as a small renormalization of Hubbard parameters, thereby justifying our practice of keeping only the lowest-orbital in all other calculations. The role of the harmonic oscillator frequency in the implementation of the Gaussian model potential is discussed, and the effect of an external magnetic field is identified to be similar to choosing a more localized electron wave function in microscopic calculations. The full matrix form of the Hamiltonian including all possible exchange terms, and several peculiar charge stability diagrams due to unphysical parameters are presented in the appendix, thus emphasizing the critical importance of a reliable microscopic model in obtaining the system parameters defining the Hamiltonian.
description: 19 pages, 15 figures
The connectivity of coastal marine populations : uncovering patterns of dispersal and the implications for management
Creators: name: Cristiani, John
Publisher: name: University of British Columbia
Year: 2022

description: Dispersal is the ecological process of organismal movement away from the location of birth. Emerging from the process of dispersal is the concept of connectivity, in which animal movement links spatially distinct populations, thus generating a landscape-scale pattern from process. Quantifying connectivity is a central challenge in marine ecology, with implications for our understanding of population dynamics and the effective management of biodiversity. Yet, there remains a limited understanding of connectivity for many marine ecosystems in terms of the dispersal patterns that emerge from the influence of physical seascape features and biological traits. This knowledge gap presents an opportunity to assess the connectivity of understudied coastal ecosystems at novel spatial and temporal scales. In this thesis, I model the potential dispersal and connectivity of coastal marine species on the Pacific coast of Canada. In Chapter 2, I identify and evaluate connectivity patterns of the invertebrate community associated with seagrass (Zostera marina) habitat. I uncover the spatial and temporal scale of networks of habitat connected by dispersal, and I identify the contribution of individual seagrass habitat patches to maintaining overall seagrass network connectivity. In Chapter 3, I assess the connectivity of the existing Marine Protected Area (MPA) network for a variety of nearshore invertebrate species, and I find that the majority of MPAs are connected and support persistent populations. In Chapter 4, I explore how connectivity can cause cascading effects of human activities that impact seagrass meadows by altering invertebrate dispersal thereby indirectly affecting other meadows in the seascape. I find that robust dispersal connections can support the persistence of most populations despite the negative effects from human activities. In sum, my thesis generates predictions on the spatial scale of dispersal, and it highlights the ecological insights gained from analyzing the emergent connectivity as a network. Together, the methodological framework and results from this thesis provide essential ecological knowledge to support our understanding of biodiversity and aid in the management and conservation of marine ecosystems.
Supporting File 1.docx
Creators: name: Aird, Tom
name: J. Farquharson, Andrew
name: Bermingham, Kate M.
name: O' Sullivan, Aifric
name: E. Drew, Janice
name: P. Carson, Brian
Publisher: name: figshare
Year: 2021
Subjects: subject: Physiology
subject: FOS: Biological sciences

description: Supporting information showing principal component analysis (figures 1A-1C) of UBE2D2 normalised skeletal muscle hMitoplex gene expression signatures in FAST (blue), WPC (red), and WPH (green) nutritional groups at baseline (A), 3 h post‐exercise (B), and post training (C) time points; serum metabolites with a VIP score > 1.5 from PLS-DA analysis (Table 1); and individual serum metabolite concentrations with associated significant differences between nutritional groups from univariate analyses (Table 2).
Discrete gauge theories of charge conjugation
Creators: name: Arias-Tamargo, Guillermo
name: Bourget, Antoine
name: Pini, Alessandro
name: Rodriguez-Gomez, Diego
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2019

description: We define gauge theories whose gauge group includes charge conjugation as well as standard $\mathrm{SU}(N)$ transformations. When combined, these transformations form a novel type of group with a semidirect product structure. For $N$ even, we show that there are exactly two possible such groups which we dub $\widetilde{\mathrm{SU}}(N)_{\mathrm{I,II}}$. We construct the transformation rules for the fundamental and adjoint representations, allowing us to explicitly build four-dimensional $\mathcal{N}=2$ supersymmetric gauge theories based on $\widetilde{\mathrm{SU}}(N)_{\mathrm{I,II}}$ and understand from first principles their global symmetry. We compute the Haar measure on the groups, which allows us to quantitatively study the operator content in protected sectors by means of the superconformal index. In particular, we find that both types of $\widetilde{\mathrm{SU}}(N)_{\mathrm{I,II}}$ groups lead to non-freely generated Coulomb branches.
RECETTORI COLINERGICI NICOTINICI NEURONALI E NON-NEURONALI: ANALISI DEGLI EFFETTI DEL TRATTAMENTO CRONICO CON NICOTINA IN CONDIZIONI FISIOLOGICHE E PATOLOGICHE
Creators: name: FASOLI, FRANCESCA MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: I nAChRs sono largamente espressi nel sistema nervoso centrale (SNC) e periferico (SNP), dove funzionano come i classici canali ionici attivati da ligando, facilitando l?ingresso di calcio e promuovendo il rilascio di neurotrasmettitori. L?esposizione cronica alla nicotina, agonista che mima l?azione del ligando endogeno acetilcolina e componente additiva presente nel tabacco, determina una serie di adattamenti cellulari, che sono responsabili dell?instaurarsi della dipendenza da fumo di sigaretta e degli effetti neurobiologici e fisiologici ad essa associati. L?eterogeneit� funzionale di questa famiglia recettoriale, ha stimolato negli anni interesse per il loro studio e per approfondire gli effetti del trattamento cronico e dell?astinenza da nicotina. Nella prima parte di questo lavoro, ci siamo focalizzati sugli effetti in vivo dell?esposizione cronica a nicotina. In particolare, abbiamo analizzato gli effetti sul recettore nativo ?4?2; tale sottotipo pu� esistere in due differenti stechiometrie, con due o tre copie della subunit� ? nel pentamero, che presentano diverse propriet� funzionali e sono differentemente regolate dal trattamento cronico con nicotina. Gli effetti addittivi della nicotina, sostanza di per se non cancerogena, incentivano il consumo di tabacco, e la presenza nel fumo di sigaretta di sostanze che sono potenti agenti cancerogeni, quali le nitrosamine NNN e NNK e le amine eterocicliche, determinano la comparsa nel DNA di mutazioni, che portano alla trasformazione neoplastica e allo sviluppo di cancro. La correlazione consumo di tabacco-insorgenza di tumore, � particolarmente evidente nel caso del tumore polmonare, dove la nicotina sostiene la crescita tumorale e partecipa alla fase di metastatizzazione, regolando signaling intracellulari che mediano proliferazione cellulare, apoptosi e angiogenesi. La recente scoperta che i nAChRs sono espressi anche in cellule non-neuronali, quali cellule endoteliali, cheratinociti, cellule del sistema immunitario e cellule gliali, ha spinto numerosi gruppi a indagare il ruolo dei nAChRs anche in tessuti extra-neuronali e in condizioni patologiche. La seconda parte di questo progetto ha avuto lo scopo di determinare quale fosse l?effetto del trattamento con nicotina e con antagonisti nicotinici sulla crescita di cellule di glioma e su colture primarie umane di glioblastoma, poich� rimane ancora da chiarire il ruolo del fumo sull?eziologia dei gliomi.
Ramification theory for varieties over a local field
Creators: name: Kato, Kazuya
name: Saito, Takeshi
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14G20, 11G25

description: We define generalizations of classical invariants of wild ramification for coverings on a variety of arbitrary dimension over a local field. For an l-adic sheaf, we define its Swan class as a 0-cycle class supported on the wild ramification locus. We prove a formula of Riemann-Roch type for the Swan conductor of cohomology together with its relative version, assuming that the local field is of mixed characteristic. We also prove the integrality of the Swan class for curves over a local field as a generalization of the Hasse-Arf theorem. We derive a proof of a conjecture of Serre on the Artin character for a group action with an isolated fixed point on a regular local ring, assuming the dimension is 2.
description: 159 pages, some corrections are made
Additional file 2 of Process evaluation of a reablement training program for homecare staff to encourage independence in community-dwelling older adults
Creators: name: Rooijackers, Teuni H.
name: G. A. Rixt Zijlstra
name: Rossum, Erik Van
name: Vogel, Ruth G. M.
name: Veenstra, Marja Y.
name: Kempen, Gertrudis I. J. M.
name: Metzelthin, Silke F.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Interview guide for focus group interview with program trainers (n = 4).
Entanglement dynamics of three-qubit states in many-sided noisy channels
Creators: name: Siomau, Michael
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study entanglement dynamics of pure three-qubit Greenberger-Horne-Zeilinger-type (GHZ-type) entangled states when one, two or three qubits being subjected to general local noise. Employing a lower bound for three-qubit concurrence as an entanglement measure, we show that for some many-sided noisy channels the entanglement dynamics can be complete described by the evolution of the entangled states in single-sided channels.
description: 18 references (Previous version of this article contains mistakes)
Additional file 1 of Process evaluation of a reablement training program for homecare staff to encourage independence in community-dwelling older adults
Creators: name: Rooijackers, Teuni H.
name: G. A. Rixt Zijlstra
name: Rossum, Erik Van
name: Vogel, Ruth G. M.
name: Veenstra, Marja Y.
name: Kempen, Gertrudis I. J. M.
name: Metzelthin, Silke F.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Interview guide for focus group interviews with homecare staff (n = 23).
New physics in t-> b W decay at next-to-leading order in QCD
Creators: name: Drobnak, Jure
name: Fajfer, Svjetlana
name: Kamenik, Jernej F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We consider contributions of non-standard tbW effective operators to the decay of an unpolarized top quark into a bottom quark and a W gauge boson at next-to-leading order in QCD. We find that the dipole operator O_{LR} contribution to the transverse-plus W helicity fraction F_+ is significantly enhanced compared to the leading order result at non-vanishing bottom quark mass. Nonetheless, presently the most sensitive observable to direct O_{LR} contributions is the longitudinal W helicity fraction F_L. In particular, the most recent CDF measurement of F_L already provides the most stringent upper bound on O_{LR} contributions, even when compared with indirect bounds from the rare decay B -> X_s gamma.
description: 5 pages
title: Analysis of SHRP2 Speeding Data [Traffic Tech]
title: Traffic Tech: Analysis of SHRP2 Speeding Data: Traffic Tech
titleType: AlternativeTitle
Creators: name: National Highway Traffic Safety Administration
Publisher: name: National Highway Traffic Safety Administration
publisherIdentifier: https://ror.org/04gcfqs37
publisherIdentifierScheme: ROR
Year: 2020
Subjects: classificationCode: https://trt.trb.org/term/90686
subject: Speeding
classificationCode: https://trt.trb.org/term/91863
subject: Behavior
classificationCode: https://trt.trb.org/term/91864
subject: Risk taking
classificationCode: https://trt.trb.org/term/97323
subject: Automatic data collection systems

description: Speeding-related crashes continue to be a serious issue in the United States. Attempts to address this problem through a variety of approaches have not led to a substantial reduction in speeding-related safety problems. A better understanding of speeding behavior is needed to inform development of new speeding countermeasures. New insights on speeding behavior are being gathered through naturalistic driving studies (NDS), which collect data on driving behavior from drivers as they engage in their normal dayto- day driving. The Strategic Highway Research Program 2 (SHRP2), a large naturalistic study, collected driving data from 3,539 passenger vehicle drivers over 12 to 24 months in six regional sites in the United States, generating approximately 4,200 driver years of data and up to 5.4 million trip files. The SHRP2 NDS data includes real-time vehicle records, such as GPS, speed, acceleration, braking, steering, and forward radar, as well as multiple video views around and inside the vehicle. This study, which included data from 2,357 drivers, is the first to use the SHRP2 data to examine speeding behavior.
Diffractive arrays of gold nanoparticles near an interface: critical role of the substrate
Creators: name: Auguié, Baptiste
name: Bendaña, Xesús M.
name: Barnes, William L.
name: de Abajo, F. Javier García
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The optical properties of periodic arrays of plasmonic nanoantennas are strongly affected by coherent multiple scattering in the plane of the array, which leads to sharp spectral resonances in both transmission and reflection when the wavelength is commensurate with the period. We demonstrate that the presence of a substrate (i.e., an asymmetric refractive-index environment) can inhibit long-range coupling between the particles and suppress lattice resonances, in agreement with recent experimental results. We find the substrate-to-superstrate index contrast and the distance between the array and the interface to be critical parameters determining the strength of diffractive coupling. Our rigorous electromagnetic simulations are well reproduced by a simple analytical model. These findings are important in the design of periodic structures and in the assessment of their optical resonances for potential use in sensing and other photonic technologies.
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Creators: name: Adeyemo, Adebowale A.
name: Zaghloul, Norann A.
name: Chen, Guanjie
name: Doumatey, Ayo P.
name: Leitch, Carmen C.
name: Hostelley, Timothy L.
name: Nesmith, Jessica E.
name: Zhou, Jie
name: Bentley, Amy R.
name: Shriner, Daniel
name: Fasanmade, Olufemi
name: Okafor, Godfrey
name: Eghan, Benjamin
name: Agyenim-Boateng, Kofi
name: Chandrasekharappa, Settara
name: Adeleye, Jokotade
name: Balogun, William
name: Owusu, Samuel
name: Amoah, Albert
name: Acheampong, Joseph
name: Johnson, Thomas
name: Oli, Johnnie
name: Adebamowo, Clement
name: Collins, Francis
name: Dunston, Georgia
name: Rotimi, Charles N.
name: Chen, Ji
name: Sun, Meng
name: Pirie, Fraser
name: Carstensen, Tommy
name: Pomilla, Cristina
name: Young, Elizabeth H.
name: Sandhu, Manjinder
name: Morris, Andrew P.
name: Barroso, Inês
name: McCarthy, Mark I.
name: Mahajan, Anubha
name: Wheeler, Eleanor
name: Motala, Ayesha A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/706/134
/631/208/4041/3196
/631/208/205/2138
/692/163/2743/137/773
/38/43
/38/109
/64/116
/14/19
/13/2
/13/31
/13/51
article

description: Abstract: Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10−9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations.
Detection of campylobacter jejuni using a hybrid paper/polymer-based microfluidic device based on the recombinase polymerase amplification and lateral flow assay
Creators: name: Chen, Yunxuan
Publisher: name: University of British Columbia
Year: 2023

description: Campylobacter jejuni is recognized as the most common species in the genus Campylobacter to cause foodborne diseases globally. Main reservoirs harboring C. jejuni are poultry products that are associated with the majority of illnesses, making a demand for effective detection methods for point-of-care diagnostics. The gold standard method involving tedious microbiological culture isolation and temperature-varied polymerase chain reaction (PCR) detection cannot achieve the use either on site or in resource-reduced settings. We aimed to integrate paper-based DNA extraction, isothermal nucleic acid amplification and lateral flow detection on a hybrid paper/polymer-based microfluidic device that it is portable and easy to use outside laboratory. Recombinase polymerase amplification (RPA) was conducted isothermally and benefited from short incubation time (10-20 min). Hybrid paper/polymer-based microfluidic device was fabricated by wax printing on the chromatography paper containing a cellulose paper dipstick for DNA extraction to avoid pipetting, RPA reaction zones and attached with a lateral flow dipstick for endpoint diagnostics. Overall, RPA reaction was completed in 20 min and demonstrated 100% specificity to C. jejuni against 9 other Campylobacter subspecies strains and 11 non-Campylobacter strains. The limit of detection was 46 CFU/mL with DNA extracted on the cellulose paper, 100-fold more sensitive than PCR. The sensitivity was reduced on the integrated hybrid paper/polymer-based microfluidic device, showing the limit of detection of 460 CFU/mL. In addition, the microfluidic device was capable of detecting C. jejuni spiked at concentrations ranging from 10 to 10² CFU/mL on chicken breast meat after enrichment for 5-10 h. For spiking C. jejuni >10³ CFU/mL, the microfluidic device managed to confirm positive results immediately without bacterial enrichment. RPA reagents and primers remained stable on paper at room temperature for 12 h and could be lyophilized on paper for 3 days with consistent sensitivity. For storage time within 25 days, the sensitivity of the microfluidic device was reduced to 10³ CFU/mL. The use of the hybrid paper/polymer-based microfluidic device enabled detection of Campylobacter contamination in food samples with high specificity and sensitivity. It showed the potential as a reliable point-of-care diagnostic platform for in-field conditions owning to its low-cost, portability, and simplicity.
QUANTUM AND SEMICLASSICAL METHODS FOR RATE CONSTANT CALCULATIONS
Creators: name: AIETA, CHIARA DONATELLA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Chemical reactions are intrinsically dynamical processes. Reaction rate constants, and thus the understanding of chemical kinetics, can be in principle obtained at a very detailed level if one is able to compute the real time quantum dynamics for the reactive system. Unfortunately, the numerical implementation of real time quantum dynamics is very hard to perform, especially for high dimensional systems, because the computational effort scales exponentially with the number of degrees of freedom. In this Ph.D. thesis, two open problems in reaction rate theory have been addressed. The first one is to extend to high dimensional systems the inclusion of quantum effects in rate constant computations. The second issue deal with the inclusion of real time dynamics into very accurate rate constants calculations. The thesis is organized as follows. After a general Introduction, the second chapter is an overview of the state of the art in reaction rate theory. Then, in the third chapter, the derivation of Miller's Semiclassical Transition State Theory (SCTST) is recalled. SCTST is the method employed to obtain accurate and quantum-corrected rate constants for high dimensional reactions. In chapter 4, a novel parallel implementation of this theory (that has also been released as an open source code into J. R. Barker's MultiWell suite of codes) is described together with its application to high dimensional systems. In the following chapters, a new quantum rate approach able to include real time dynamics effects is presented. Derivation and applications of the latter are thoroughly described in chapter 6. The thesis ends with some perspectives about possible future developments.
Additional file 2 of A scoping review of severe maternal morbidity: describing risk factors and methodological approaches to inform population-based surveillance
Creators: name: Korst, Lisa M.
name: Gregory, Kimberly D.
name: Nicholas, Lisa A.
name: Saeb, Samia
name: Reynen, David J.
name: Troyan, Jennifer L.
name: Greene, Naomi
name: Fridman, Moshe
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 2. Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) Checklist.
title: Barriers to Justpeace in the Republic of Dagestan
Creators: name: Tippett, Diane
Publisher: name: University of Sydney
Year: 2023

description: The ongoing conflict in Dagestan can be classed as a protracted social conflict (“PSC”) according to Azar’s 1990 theory which focusses on the multi-faceted nature of enduring ethnopolitical conflict. That is, the recent self-sustaining patterns of conflict and violence in Dagestan have multiple sources and causes and can be seen as based on deep-rooted identity-based antagonism thereby meeting the classification of a PSC within Azar’s conceptualisation. Exploration of Azar’s four PSC “conflict determinants” are used as the functional infrastructure of this dissertation to comprehensively examine the structures and the processes that drive and sustain conflict in Dagestan. These four conflict determinants are: 1. State actions and strategies, 2. Deprivation of human needs, 3. Communal content, and 4. International linkages. This analysis, however, diverges from Azar’s examination of process dynamics as separate to conflict determinants. Instead, this dissertation borrows from Leventis’ and Tsokkalides’ approach to PSC analysis which examines how each PSC “determinant” also creates new intergroup social dynamics that perpetuate communal conflict. This modified understanding of Azar’s PSC framework is used to facilitate answering this dissertation’s main research question: what are the barriers to achieving justpeace in The Republic of Dagestan?
Correlated random hopping disorder in graphene at high magnetic fields: Landau level broadening and localization properties
Creators: name: Pereira, A. L. C.
name: Lewenkopf, C. H.
name: Mucciolo, E. R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the density of states and localization properties of the lowest Landau levels of graphene at high magnetic fields. We focus on the effects caused by correlated long-range hopping disorder, which, in exfoliated graphene, is induced by static ripples. We find that the broadening of the lowest Landau level shrinks exponentially with increasing disorder correlation length. At the same time, the broadening grows linearly with magnetic field and with disorder amplitudes. The lowest Landau level peak shows a robust splitting, whose origin we identify as the breaking of the sublattice (valley) degeneracy.
description: 9 pages, 8 figures - 1 Figure (Fig.5) and a few new references added
Understanding the Mechanism of Recruitment of Esco1 and Esco2 to Cohesin
Creators: name: Sulaiman, Nurul Atiqah
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: For cells to faithfully transmit their genetic material to the daughter cells, chromosome segregation during mitosis must be accurately and timely executed. One way to ensure this is by keeping the duplicated chromosomes (sister chromatids) together until they are separated at the metaphase-to-anaphase transition. Sister chromatids are held together by a cohesin complex, comprising Smc1, Smc3, Scc1 and SA1/2. Several proteins associate with cohesin to govern the cohesive state of sister chromatids and regulate chromosome segregation. Two acetyltransferases, Esco1 and Esco2, associate with cohesin in a cell cycle dependent manner to establish sister chromatid cohesion by acetylating Smc3. A loss-of-function mutation of Esco2 has been identified as the underlying cause of a genetic disorder, Roberts syndrome, and overexpression of Esco1 and Esco2 has been reported in several cancers. However, the regulation of Esco1 and Esco2 and their mechanism of recruitment to chromatin in human cells is still not fully understood. Therefore, in my research, I aimed to investigate the mechanism by which Esco1 and Esco2 are recruited to chromatin during the cell cycle and the effect of their overexpression on the cell cycle. I show that Esco1 and Esco2 are recruited to chromatin during DNA replication to acetylate Smc3. Through co-immunoprecipitation and pull-down assays, I demonstrate a novel interaction between human Esco1 and the MCM complex and PCNA and confirm a previously known interaction of Esco1 with cohesin and Pds5A/B during DNA replication. In contrast, I found that Esco2 interacts with the same set of proteins, but not with PCNA and Pds5B. For the first time, I show that overexpression of Esco1 and Esco2 in HeLa cells may induce apoptosis and that Esco2 overexpression, particularly, inhibits DNA replication. Additionally, my preliminary experiment indicates that Esco1 and Esco2 protein levels may increase in response to DNA damage.
Additional file 1 of A scoping review of severe maternal morbidity: describing risk factors and methodological approaches to inform population-based surveillance
Creators: name: Korst, Lisa M.
name: Gregory, Kimberly D.
name: Nicholas, Lisa A.
name: Saeb, Samia
name: Reynen, David J.
name: Troyan, Jennifer L.
name: Greene, Naomi
name: Fridman, Moshe
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1. Newcastle-Ottawa Quality Assessment Scale (adapted for cross sectional studies with healthcare data for research question: What are the risk factors for severe maternal morbidity associated with the delivery admission?
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk
Creators: name: Wu, Lang
name: Yang, Yaohua
name: Guo, Xingyi
name: Shu, Xiao-Ou
name: Cai, Qiuyin
name: Shu, Xiang
name: Li, Bingshan
name: Tao, Ran
name: Wu, Chong
name: Nikas, Jason B.
name: Sun, Yanfa
name: Zhu, Jingjing
name: Brenner, Hermann
name: John, Esther M.
name: Clements, Judith
name: Grindedal, Eli Marie
name: Stanford, Janet L.
name: Kote-Jarai, Zsofia
name: Haiman, Christopher A.
name: Zheng, Wei
name: Long, Jirong
name: Eeles, Rosalind A.
name: Henderson, Brian E.
name: Schumacher, Fredrick R.
name: Easton, Douglas
name: Benlloch, Sara
name: Olama, Ali Amin Al
name: Muir, Kenneth
name: Berndt, Sonja I.
name: Conti, David V.
name: Wiklund, Fredrik
name: Chanock, Stephen
name: Gapstur, Susan M.
name: Stevens, Victoria L.
name: Tangen, Catherine M.
name: Batra, Jyotsna
name: Gronberg, Henrik
name: Pashayan, Nora
name: Schleutker, Johanna
name: Albanes, Demetrius
name: Weinstein, Stephanie
name: Wolk, Alicja
name: West, Catharine
name: Mucci, Lorelei
name: Cancel-Tassin, Géraldine
name: Koutros, Stella
name: Sorensen, Karina Dalsgaard
name: Neal, David E.
name: Hamdy, Freddie C.
name: Donovan, Jenny L.
name: Travis, Ruth C.
name: Hamilton, Robert J.
name: Ingles, Sue Ann
name: Rosenstein, Barry S.
name: Lu, Yong-Jie
name: Giles, Graham G.
name: Kibel, Adam S.
name: Vega, Ana
name: Kogevinas, Manolis
name: Penney, Kathryn L.
name: Park, Jong Y.
name: Cybulski, Cezary
name: Nordestgaard, Børge G.
name: Maier, Christiane
name: Kim, Jeri
name: Teixeira, Manuel R.
name: Neuhausen, Susan L.
name: De Ruyck, Kim
name: Razack, Azad
name: Newcomb, Lisa F.
name: Gamulin, Marija
name: Kaneva, Radka
name: Usmani, Nawaid
name: Claessens, Frank
name: Townsend, Paul A.
name: Dominguez, Manuela Gago
name: Roobol, Monique J.
name: Menegaux, Florence
name: Khaw, Kay-Tee
name: Cannon-Albright, Lisa
name: Pandha, Hardev
name: Thibodeau, Stephen N.
name: Hunter, David J.
name: Blot, William J.
name: Riboli, Elio
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/67/2324
/631/67/68
/631/208
article

description: Abstract: It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.
title: PAINTING POETRY: THE INTERTWINING OF THE ART AND VERSE OF DANTE GABRIEL ROSSETTI
Creators: name: Ivie, Janice L
Publisher: name: Maryland Shared Open Access Repository
Year: 2008

description: Dante Gabriel Rossetti (1828-1882), painter and poet, was one of the founders of the Pre-Raphaelite Brotherhood. From a young age Rossetti was keenly aware of the interrelationships between art and verse and was convinced that painting and poetry were so closely related as to be inseparable. In both poetry and paintings, Rossetti's most frequent subject was Love, which he, like Dante, his namesake and guide, believed to be the driving force of his life. DGR chose to accept the opposing aspects of Sacred and Profane Love as a unified whole. He also chose to unify the sister arts of Painting and Poetry. Rossetti created what he called "picture-sonnets." These were double-works of art wherein a painting or drawing and a poem, both of his own invention, were made to be viewed and read simultaneously. The artist presented both the painting and poem to the viewer/reader by placing the verse within the painting itself or on the frame. Through an examination of the paintings and poetry of Dante Gabriel Rossetti, the intertwining of his verbal and visual images, one can trace Rossetti's gradual conflation of the Sacred and Profane aspects of Love and his understanding of his dual identity as painter and poet.
Apolarity, Hessian and Macaulay polynomials
Creators: name: Di Biagio, Lorenzo
name: Postinghel, Elisa
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 14N15 (Primary) 14J70 (Secondary)

description: A result by Macaulay states that an Artinian graded Gorenstein ring R of socle dimension one and socle degree b can be realized as the apolar ring of a homogeneous polynomial f of degree b. If R is the Jacobian ring of a smooth hypersurface g=0, then b is just equal to the degree of the Hessian polynomial of g. In this paper we investigate the relationship between f and the Hessian polynomial of g.
description: 12 pages. Improved exposition, minor corrections
Additional file 10 of Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice
Creators: name: Liang, Yaohui
name: Song, Chao
name: Li, Jieli
name: Li, Ting
name: Zhang, Chunlei
name: Zou, Yi
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Hematology

description: Additional file 10: Table S6. Breeding schemes.
Brain-behaviour modes of covariation in healthy and clinically depressed young people
Creators: name: Mihalik, Agoston
name: Ferreira, Fabio S.
name: Rosa, Maria J.
name: Moutoussis, Michael
name: Ziegler, Gabriel
name: Monteiro, Joao M.
name: Portugal, Liana
name: Adams, Rick A.
name: Romero-Garcia, Rafael
name: Vértes, Petra E.
name: Kitzbichler, Manfred G.
name: Váša, František
name: Vaghi, Matilde M.
name: Bullmore, Edward T.
name: Fonagy, Peter
name: Goodyer, Ian M.
name: Jones, Peter B.
name: Dolan, Raymond
name: Mourão-Miranda, Janaina
name: Hauser, Tobias
name: Neufeld, Sharon
name: Clair, Michelle St
name: Whitaker, Kirstie
name: Inkster, Becky
name: Prabhu, Gita
name: Ooi, Cinly
name: Toseeb, Umar
name: Widmer, Barry
name: Bhatti, Junaid
name: Villis, Laura
name: Alrumaithi, Ayesha
name: Birt, Sarah
name: Bowler, Aislinn
name: Cleridou, Kalia
name: Dadabhoy, Hina
name: Davies, Emma
name: Firkins, Ashlyn
name: Granville, Sian
name: Harding, Elizabeth
name: Hopkins, Alexandra
name: Isaacs, Daniel
name: King, Janchai
name: Kokorikou, Danae
name: Maurice, Christina
name: McIntosh, Cleo
name: Memarzia, Jessica
name: Mills, Harriet
name: O’Donnell, Ciara
name: Pantaleone, Sara
name: Scott, Jenny
name: Fearon, Pasco
name: Suckling, John
name: Van Harmelen, Anne-Laura
name: Kievit, Rogier
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/378/1689/1414
/639/705/117
/59/36
/141
/139
article

description: Abstract: Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge. This has particular relevance for mental health disorders where a failure to understand these links might hinder the development of better diagnostic approaches and therapeutics. Here, we investigated this question in 306 adolescents and young adults (14–24 y, 25 clinically depressed) using a multivariate statistical framework, based on canonical correlation analysis (CCA). By linking individual functional brain connectivity profiles to self-report questionnaires, IQ and demographic data we identified two distinct modes of covariation. The first mode mapped onto an externalization/internalization axis and showed a strong association with sex. The second mode mapped onto a well-being/distress axis independent of sex. Interestingly, both modes showed an association with age. Crucially, the changes in functional brain connectivity associated with changes in these phenotypes showed marked developmental effects. The findings point to a role for the default mode, frontoparietal and limbic networks in psychopathology and depression.