cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
GUN VIOLENCE IN AMERICA: AN EVALUATION AND ANALYSIS OF FEDERAL GUN LAWS
Creators: name: Glinkie, Donald
Publisher: name: Zenodo
Year: 2022
Subjects: qualitative
research
gun violence
laws
United States

description: With the unceasing concern of gun violence in the United States, this project explores federal gun control regulations and their impact on gun violence. Particularly, the purpose of this research paper is to determine what kinds of federal gun laws would effectively reduce gun violence by analyzing previous and current federal gun laws. Research will be based upon looking at scholarly sources that provide information on current and past gun laws; specifically, this research will include descriptions of these laws, along with information relating to their effectiveness for reducing gun violence. My analysis corroborates prior scholarly arguments that federal gun laws have ineffectively prevented unlawful gun-use in the United States due to existing loop holes that these laws allow and the unsatisfactory enforcement of these laws. By determining the ineffectiveness of preceding federal gun control laws, this paper establishes along with the support from relevant scholastic sources that in order for upcoming federal gun laws to be successful, they would need to include both stricter and better implementation measures that prevent loopholes which may override the laws’ objective. Overall, by analyzing statistical and preexisting data on previously established federal gun control laws, this analysis has been used as a blueprint for determining how future federal gun laws can be successful.
The role of Wnt signaling pathway in mammalian retinal development
Creators: name: Liu, Hong
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Molecular.
subject: Biology, Neuroscience.
subject: Biology, Animal Physiology.

description: Intercellular communication via secreted signaling molecules is essential for the generation of a normally patterned central nervous system (CNS). The mammalian retina, which is neuroectoderm derived, is an excellent model system in which to study signaling events in patterning, cell proliferation and diversification in the CNS. Although the identity and function of some signaling molecules that regulate retinal development are known, the function of many others, especially members of the Wnt family, has yet to be well characterized. Wnt ligands have been established as critical regulators of multiple developmental processes in a variety of organs and tissues during embryogenesis. To ascertain the function of Wnt signaling in the context of retinal development, I examined the expression of Wnt pathway components in the mouse neural retina. I showed that Wnt2b (formerly known as Wnt13), Wnt receptors and Wnt antagonists are expressed within and adjacent to the distal part of the eyecup, the ciliary margin (CM). beta-gal staining in the eyes of TCF/Lef-LacZ mice, a canonical Wnt pathway reporter mouse strain, revealed the highest level of reporter activity in the CM throughout retinal development. Thus, I hypothesized that canonical Wnt signaling plays a role in the specification and formation of the CM and its derivatives. To test the above hypothesis, I used several approaches to activate Wnt signaling in retinal explants from TCF/Lef-LacZ reporter mice. Ectopic expression of Wnt2b did not activate Wnt reporter activity, while over expression of Wnt3a, a well-characterized canonical Wnt pathway activator, induced reporter gene expression in the CM, but after a considerable delay. Treatment with lithium, a well-known Wnt pathway agonist, resulted in rapid upregulation of Wnt reporter activity, and alterations in morphology and gene expression that were consistent with induction of a CM identity. The expression of stabilized beta-catenin, the key mediator of canonical Wnt pathway activation, was then targeted to the peripheral retina by using a Cre-loxP approach. These transgenic mice exhibited a dramatic increase in beta-catenin-dependent signaling, as well as an expansion of the CM/ciliary epithelium in Cre-expressing region of the retina. Taken together, the findings presented in this thesis indicate that beta-catenin-mediated signaling can promote the development of the CM and its derivatives.
Political arithmetick : physician productivity in concept and measurement : draft discussion paper
Creators: name: Evans, Robert G., 1942-
Publisher: name: Centre for Health Services and Policy Research (CHSPR)
Year: 2014

description: This paper was written for the Fourth Annual Medical Workforce Conference, San Francisco, November 4-7, 1999. The organizers intent was to have the conference papers published, and to have the discussants for the papers in each session contribute a synthesis paper for that session. The papers synthesized here are: Harding, John, and Warwick Conn, 'Workforce Productivity in the Australian Medical workforce', Watanabe, Mamoru, Lynda Buske and Jill Strachan, 'Canadian Physician Workforce Productivity', Maynard, Alan and Karen Bloor, 'Workforce Productivity in the U.K. NHS: Measurement, Variation and Incentives'. Unfortunately the organizers plans for publication did not materialize. This paper reached the antepenultimate stage of being circulated to the session participants for comment and possible revisions, after which references were to have been added. But the overall project was abandoned before any comments were received, and the paper was never completed for publication. The broader issue of physician productivity has, however, re-emerged in Canada. I believe that the paper offers a useful analytic framework for addressing that topic along with fairly detailed illustrative examples of its application to the descriptive material, institutional and statistical, provided in the session papers. Much has changed since; no attempt has been made to up-date those papers. But the process of applying the analytic framework to the world as it then was (said to be) provides, I think, a clear guide for a similar application to present circumstances.
Christoph Peisert: Peking und die "nationale Form". Die repräsentative Stadtgestalt im neuen China als Zugang zu klassischen Raumkonzepten
Creators: name: Kaltenbrunner, Robert
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 64 (1997): ASIEN (Juli)
Risk factors for developing a cutaneous injection-related infection among injection drug users: a cohort study
Creators: name: Lloyd-Smith, Elisa
name: Wood, Evan
name: Zhang, Ruth
name: Tyndall, Mark
name: Montaner, Julio
name: Kerr, Thomas
Publisher: name: BioMed Central
Year: 2015

description: Background. Cutaneous injection-related infections (CIRI), such as abscesses and cellulitis, are common and preventable among injection drug users (IDU). However, risk factors for CIRI have not been well described in the literature. We sought to characterize the risk factors for current CIRI among individuals who use North America's first supervised injection facility (SIF). Methods A longitudinal analysis of factors associated with developing a CIRI among participants enrolled in the Scientific Evaluation of Supervised Injecting (SEOSI) cohort between January 1, 2004 and December 31, 2005 was conducted using generalized linear mixed-effects modelling. Results In total, 1065 participants were eligible for this study. The proportion of participants with a CIRI remained under 10% during the study period. In a multivariate generalized linear mixed-effects model, female sex (Adjusted Odds Ratio (AOR) = 1.68 [95% Confidence Interval (CI): 1.16–2.43]), unstable housing (AOR = 1.49 [95% CI: 1.10–2.03]), borrowing a used syringe (AOR = 1.60 [95% CI: 1.03–2.48]), requiring help injecting (AOR = 1.42 [95% CI: 1.03–1.94]), and injecting cocaine daily (AOR = 1.41 [95% CI: 1.02–1.95]) were associated with an increased risk of having a CIRI. Conclusion CIRI were common among a subset of IDU in this study, including females, those injecting cocaine daily, living in unstable housing, requiring help injecting or borrowing syringes. In order to reduce the burden of morbidity associated with CIRI, targeted interventions that address a range of factors, including social and environmental conditions, are needed.
Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice
Creators: name: Ghallab, Ahmed
name: Kunz, Sebastian
name: Drossel, Celine
name: Billo, Veronica
name: Friebel, Adrian
name: Georg, Mats
name: Göttlich, Richard
name: Hobloss, Zaynab
name: Hassan, Reham
name: Myllys, Maiju
name: Seddek, Abdel-Latief
name: Abdelmageed, Noha
name: Dawson, Paul A.
name: Lindström, Erik
name: Hoehme, Stefan
name: Hengstler, Jan G.
name: Geyer, Joachim
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2024
Subjects: Ntcp
OATP
ASBT
cholestasis
cholemic nephropathy

description: Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and validated a 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole-coupled taurocholic acid (3β-NBD-TCA) as a probe for intravital analysis of BA homeostasis. We compared transport of 3β-NBD-TCA to [3H]-TCA in HEK293 cells stably expressing the mouse hepatic or renal BA carriers mNtcp or mAsbt, respectively. We also studied distribution kinetics intravitally in livers and kidneys of anesthetized wildtype and mOatp1a/1b cluster knockout mice (OatpKO) with and without administration of the Ntcp inhibitor Myrcludex B and the ASBT inhibitor AS0369. In vitro, 3-NBD-TCA and [3H]-TCA showed comparable concentration- and time-dependent transport via mNtcp and mAsbt as well as similar inhibition kinetics for Myrcludex B and AS0369. Intravital analysis in the livers of wildtype and OatpKO mice revealed contribution of both mNtcp and mOatp1a/1b in the 3β-NBD-TCA uptake from the sinusoidal blood into hepatocytes. Combined deletion of mOatp1a/1b and inhibition of mNtcp by Myrcludex B blocked the uptake of 3β-NBD-TCA from sinusoidal blood into hepatocytes. This led to an increase of 3β-NBD-TCA signal in the systemic circulation including renal capillaries, followed by strong enrichment in a subpopulation of proximal renal tubular epithelial cells (TEC). The enrichment of 3β-NBD-TCA in TEC was strongly reduced by the systemic ASBT inhibitor AS0369. NBD-coupled TCA has similar transport kinetics as [3H]-TCA and can be used as a tool to study hepatorenal BA transport.
description: EXCLI Journal; 23:Doc1330; ISSN 1611-2156
Guidelines for development of routine to research motivation of universitysupporting staff in Nakhon Pathom Rajabhat University
Creators: name: Rinyaphat Phasitkunlawet
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University
Year: 2017
Subjects: motivation
routine to research
university staff

description: Journal of Management Science Nakhon Pathom Rajabhat University, 4, 2, 89-104
Günter Ederer, Jürgen Franzen: Der Sieg des himmlischen Kapitalismus. Wie der Aufstieg Chinas unsere Zukunft verändert; Günter Ederer: China. Der Sieg des himmlischen Kapitalismus; Martina Niembs: China. Wirtschaftsmacht der Zukunft
Creators: name: Schucher, Günter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 64 (1997): ASIEN (Juli)
Supplementary document for Fast and Robust Demodulation of Temperature from Sparse Sapphire Fiber Bragg Grating Spectra with Machine Learning - 6907177.pdf
Creators: name: Liu, Xiao
name: ALSALMAN, OSAMAH
name: Liu, Bo
name: Zhu, Chen
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary Material
Supplementary document for Fast and Robust Demodulation of Temperature from Sparse Sapphire Fiber Bragg Grating Spectra with Machine Learning - 6935422.pdf
Creators: name: Liu, Xiao
name: ALSALMAN, OSAMAH
name: Liu, Bo
name: Zhu, Chen
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: supplementary material
AD Smith: Knight-errant of radical democracy
Creators: name: Dunley, Ruth
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biography.
subject: History, United States.

description: Though few people have heard of A.D. Smith, this nineteenth-century knight-errant made his mark in some of the key events of his times. On a Quixotic trail that began in upstate New York, wound westward to the Ohio and Wisconsin frontier, southward to the federally occupied Sea Islands of South Carolina and finally to a mysterious death aboard a northbound steamer, Smith personified the nineteenth-century impulse to move across the American landscape. In Ohio he became involved with a paramilitary group, the Hunters' Lodge, that elected Smith the "President of the Republic of Canada." In Wisconsin, he achieved fame as the judge who dared to declare the Fugitive Slave Act of 1850 unconstitutional, lighting one of many fuses that sparked the Civil War. In South Carolina, he fought passionately for the property rights of freedmen. Not only did he move from state to state, but he also believed in a civic movement on behalf of a Jeffersonian democracy and republican ideals. Civic participation, he believed, was a fundamental part of being a good American. Hence Smith took on public roles as a justice of the peace, councilman, lawyer, judge and tax commissioner for the U.S. government. This civic impulse was also seen in his enthusiastic embrace of the reform movements of the day. The key to unlocking Smith's character, however, lies in his absolute dedication to radicalism. At the centre of this work is an examination of Smith's shifting position at the far left of the Democratic Party and how this affected Smith's actions, frequently putting him out of step with contemporaries and thwarting his ambitions. A detective story set against the backdrop of the volatile antebellum era, this socio-cultural biography pieces together methodological inquiry with a jigsaw puzzle composed of secret documents, probate records, court testimony, speeches, correspondence, newspaper coverage and genealogical research in order to tell the story of a man named Smith, of his vision for the United States, and, more generally, of the value of remembering secondary historical characters. In so doing, this biography also establishes that the viewing of the past through its own optics casts briefly into the limelight actors of transient importance who, while now forgotten, were nonetheless important in their own era.
Supplementary document for Deep learning-enhanced snapshot hyperspectral confocal microscopy imaging system - 6904301.pdf
Creators: name: Liu, Shuai
name: Zhou, Wenzhen
name: sha, hao
name: Feng, Xiaochen
name: Chen, Bin
name: Zhang, Jian
name: Han, Sanyang
name: Li, Xiu
name: zhang, yongbing
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary Information
IMPROVING THE METHODOLOGICAL PREPARATION OF FUTURE TEACHERS FOR THE EFFECTIVE ORGANIZATION OF EDUCATIONAL CLASSES.
Creators: name: Sheralieva, Nasiba
Publisher: name: Zenodo
Year: 2024

description: in this article, the subject of future upbringing in general secondary education schools is considered to develop and interest students in national values in the process of teaching teachers the subject of” upbringing", and in the process of teaching the subject of” upbringing " to form their interests in national values in students of general secondary education schools, philosophical, psychological, pedagogical, didactic, methodological, based on the analysis of literature and the teaching of the subject “upbringing”, students ' kereactive opinion was reflected in improving the didactic provision of the formation of their interest in national values in students of general secondary schools and improving the educational processes of students of general secondary schools on a competency approach, and in the effective organization of educational classes for students.
La perception d'enseignantes et d'enseignants francophones de la 9e et de la 10e année au sujet du cours d'Éducation à la citoyenneté
Creators: name: Poirier, Sébastien
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Education, Social Sciences.

description: Au tournant du 21e siècle, le Canada fait face à plusieurs problèmes sociaux tels l'augmentation de l'immigration, la mondialisation, le désintérêt des jeunes relativement à la participation politique et sociale, etc. Ainsi, l'éducation à la citoyenneté est devenu un thème important depuis les 20 dernières années pour contrer à ces problèmes. Elle vise l'acquisition d'attitudes, de valeurs et de compétences permettant aux citoyens de demain de se préparer aujourd'hui à mieux jouer leur rôle. En l'an 2000, l'Ontario a été la première province du Canada à développer un cours spécifique à l'éducation à la citoyenneté afin de développer des citoyens avisés, dynamiques et engagés. Cependant, peu d'études se sont intéressés à la manière dont ce cours est enseigné dans les écoles. Cette étude a donc pour but de connaître la perception des enseignantes et d'enseignants francophones de la 9e et de la 10e année de la région d'Ottawa au sujet du cours d'éducation à la citoyenneté. Pour y parvenir, des entretiens ont été réalisés auprès de 11 enseignantes et enseignants chargés d'enseigner le cours d'éducation à la citoyenneté dans les écoles francophones de la région d'Ottawa. L'approche utilisée pour analyser les données recueillies s'est faite par la technique de l'analyse de contenu (L'Écuyer, 1987). (Abstract shortened by UMI.)
Supplementary document for Energy-efficient dispersion compensation for digital micromirror device - 6923419.pdf
Creators: name: Liu, Linxian
name: Zhang, Yingxuan
name: Chen, Jiayin
name: He, Qiaozhi
name: Shen, Yang
name: Qu, Yuan
name: Yang, Jiamiao
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: supplementary material
Supplementary document for Energy-efficient dispersion compensation for digital micromirror device - 6921585.pdf
Creators: name: Liu, Linxian
name: Zhang, Yingxuan
name: Chen, Jiayin
name: He, Qiaozhi
name: Shen, Yang
name: Qu, Yuan
name: Yang, Jiamiao
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary material
Mitigating Crossing Risks: A Study of Pedestrian Behavior in Anambra State, Nigeria: A Structural Equation Modeling Approach
Creators: name: Obiorah, Michael Chukwuemeka
name: Zhou, Hongmei
Publisher: name: Zenodo
Year: 2024

description: The purpose of this study is to mitigate the probability of pedestrian accidents in Anambra State, Nigeria, by analyzing pedestrian behaviour using structural equation modelling (SEM). The data on demographics, perceived behavioural control in crossing scenarios, subjective norms, attitudes towards traffic safety, and behavioural intents were gathered using a standardized questionnaire. A total of 243 individuals 123 men (50.6%) and 120 women (49.4%) completed the online survey. The majority of respondents (91.4%) were between the ages of 19 and 35.

The results reveal that while attitude did not significantly predict behavioral intentions, subjective norms and perceived behavioral control played crucial roles, with p-values of 0.004 and 0.001, respectively. This underscores the importance of considering social influences and perceived control in shaping pedestrian behavior. Notably, demographic characteristics did not show significance in this study.

The study also highlights the necessity of customized interventions based on socioeconomic factors and infrastructure modifications in order to enhance pedestrian safety. Technology improvements and educational initiatives based on the theory of planned behaviour (TPB) are suggested as useful tactics to lower the risks associated with road-crossing.
Biosynthesis of storage compounds by Rhodococcus jostii RHA1 and global identification of genes involved in their metabolism
Creators: name: Hernández, Martín A
name: Mohn, William W.
name: Martínez, Eliana
name: Rost, Enrique
name: Alvarez, Adrián F
name: Alvarez, Héctor M
Publisher: name: BioMed Central
Year: 2015

description: Background: Members of the genus Rhodococcus are frequently found in soil and other natural environments and are highly resistant to stresses common in those environments. The accumulation of storage compounds permits cells to survive and metabolically adapt during fluctuating environmental conditions. The purpose of this study was to perform a genome-wide bioinformatic analysis of key genes encoding metabolism of diverse storage compounds by Rhodococcus jostii RHA1 and to examine its ability to synthesize and accumulate triacylglycerols (TAG), wax esters, polyhydroxyalkanoates (PHA), glycogen and polyphosphate (PolyP). Results We identified in the RHA1 genome: 14 genes encoding putative wax ester synthase/acyl-CoA:diacylglycerol acyltransferase enzymes (WS/DGATs) likely involved in TAG and wax esters biosynthesis; a total of 54 genes coding for putative lipase/esterase enzymes possibly involved in TAG and wax ester degradation; 3 sets of genes encoding PHA synthases and PHA depolymerases; 6 genes encoding key enzymes for glycogen metabolism, one gene coding for a putative polyphosphate kinase and 3 putative exopolyphosphatase genes. Where possible, key amino acid residues in the above proteins (generally in active sites, effectors binding sites or substrate binding sites) were identified in order to support gene identification. RHA1 cells grown under N-limiting conditions, accumulated TAG as the main storage compounds plus wax esters, PHA (with 3-hydroxybutyrate and 3-hydroxyvalerate monomers), glycogen and PolyP. Rhodococcus members were previously known to accumulate TAG, wax esters, PHAs and polyP, but this is the first report of glycogen accumulation in this genus. Conclusion RHA1 possess key genes to accumulate diverse storage compounds. Under nitrogen-limiting conditions lipids are the principal storage compounds. An extensive capacity to synthesize and metabolize storage compounds appears to contribute versatility to RHA1 in its responses to environmental stresses.
Malurus coronatus subsp. macgillivrayi Mathews 1913
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Maluridae
Malurus
Malurus coronatus
Malurus coronatus macgillivrayi mathews

description: Malurus coronatus macgillivrayi Mathews
 Malurus coronatus macgillivrayi Mathews, 1913c: 9 (Augustus Downs, Leichhardt River, Gulf of Carpentaria, Queensland).
 Now Malurus coronatus macgillivrayi Mathews, 1913. See Schodde, 1982: 67, and Schodde and Mason, 1999: 96.
HOLOTYPE: AMNH 602736, adult male, collected on Augustus Downs, 18.33S, 139.53E (Storr, 1984: 179), Leichardt River, Queensland, Australia, on 24 June 1910, by William McLennan for W.D.K. Macgillivray. From the Mathews Collection (no. 17239) via the Rothschild Collection.
 COMMENTS: Mathews did not give his catalog number of the type in the original description, but the above number is written on both the Mathews and Rothschild type labels of AMNH 602736; the description is of an adult male. AMNH 602737, immature male, collected at Caloola, on the Leichhardt River, on 14 June 1910, and cataloged as Mathews number 17240, is a paratype. These are the only two specimens of macgillivrayi that came to AMNH with the Rothschild Collection. Both specimens bear a yellow ‘‘Figured’’ label, indicating that they were models for figures in Mathews (1922e: pl. 464, lower pair of figs., opp. p. 116, text p. 126), where the adult male is confirmed as the type of macgillivrayi.
For information on the collecting activities of McLennan and Macgillivray, see Macgillivray (1914) and Mathews (1919a, 1927b).
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 113, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Todopsis cyanocephalus subsp. dohertyi Rothschild and Hartert
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Maluridae
Todopsis
Todopsis cyanocephalus
Todopsis cyanocephalus dohertyi rothschild and hartert

description: Todopsis cyanocephalus dohertyi Rothschild and Hartert
 Todopsis cyanocephalus dohertyi Rothschild and Hartert, 1903b: 477 (Takar).
 Now Malurus cyanocephalus cyanocephalus (Quoy and Gaimard, 1830). See Schodde, 1982: 63, and Coates, 1990: 92.
HOLOTYPE: AMNH 602822, adult female, collected at Takar, 02.02S, 139.08E (USBGN, 1982a), Papua Province, Indonesia, in November 1896, by William Doherty (no. T.247). From the Rothschild Collection.
COMMENTS: Rothschild and Hartert gave Doherty’s unique field number of the holotype in the original description. They listed three adult males, one immature male, and three females in addition to the holotype. These paratypes are AMNH 602823–602829.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 113, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Stipiturus malachurus subsp. tregellasi Mathews
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Maluridae
Stipiturus
Stipiturus malachurus
Stipiturus malachurus tregellasi mathews

description: Stipiturus malachurus tregellasi Mathews
 Stipiturus malachurus tregellasi Mathews, 1912c: 45 (Victoria (Frankston)).
 Now Stipiturus malachurus malachurus (Shaw, 1798). See Schodde, 1982: 133, and Schodde and Mason, 1999: 101–103.
HOLOTYPE: AMNH 602921, adult male, collected at Frankston, 38.08S, 145.07E (Times Atlas), Victoria, Australia, on 17 May 1909, by L.G. Chandler. From the Mathews Collection (no. 11148) via the Rothschild Collection.
 COMMENTS: Mathews gave his catalog number of the holotype in the original description; in his catalog, the specimen was credited to Chandler. It bears a yellow ‘‘ Figured’ ’ label, indicating that it was illustrated in Mathews (1922e: pl. 465, lower left-hand fig., opp. p. 131, text p. 133), where it is confirmed as the type of tregellasi. AMNH 602922 (Mathews no. 8556), male from Frankston, collected by Tregellas on 17 January 1911, is a paratype. Mathews number 11147 is a female specimen collected by Tregellas on 25 February 1911. This specimen, also a paratype, did not come to AMNH with the Rothschild Collection. AMNH 602923–602925, males collected in April and December 1908 by Chandler at Frankston, are possible paratypes, but I did not find them listed in Mathews’ catalog to establish their availability prior to the description of tregellasi.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 113, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Thiazolidines derivatives and their anti-inflammatory activity in LPS-induced RAW 264.7 macrophages: a systematic review and meta-analysis
Creators: name: Mohr, Eduarda Talita Bramorski
name: Lubschinski, Tainá Larissa
name: de Oliveira, Júlia Meller Dias
name: de Oliveira, Paula Giarola Fragoso
name: Borba, Beatriz Garcia Mendes
name: Demarchi, Izabel Galhardo
name: Dalmarco, Eduardo Monguilhott
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Thiazolidine scaffolds have been investigated for decades, due to their wide range of biological activity. In this way, the main objective of this systematic review was to elucidate the anti-inflammatory activity of thiazolidine derivatives against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. From 9718 identified registers, 13 articles were included, where 11 studies evaluated thiazolidinediones. The summary of relevance demonstrated that seven studies (53.8%) were relevant without restrictions, and 6 (46.2%) were relevant with restrictions. The certainty in cumulative evidence was considered moderate and the six studies included in the meta-analysis demonstrated the positive activity of thiazolidinediones against NO production when compared to the negative LPS control.
Long-term actions of interleukin-1β on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization
Creators: name: Gustafson-Vickers, Sabrina L
name: Lu, Van B
name: Lai, Aaron Y
name: Todd, Kathryn G
name: Ballanyi, Klaus
name: Smith, Peter A
Publisher: name: BioMed Central
Year: 2015

description: Background: Cytokines such as interleukin 1β (IL-1β) have been implicated in the development of central sensitization that is characteristic of neuropathic pain. To examine its long-term effect on nociceptive processing, defined medium organotypic cultures of rat spinal cord were exposed to 100 pM IL-1β for 6–8 d. Interleukin effects in the dorsal horn were examined by whole-cell patch-clamp recording and Ca²⁺ imaging techniques. Results Examination of the cultures with confocal Fluo-4 AM imaging showed that IL-1β increased the change in intracellular Ca²⁺ produced by exposure to 35–50 mM K⁺. This is consistent with a modest increase in overall dorsal horn excitability. Despite this, IL-1β did not have a direct effect on rheobase or resting membrane potential nor did it selectively destroy any specific neuronal population. All effects were instead confined to changes in synaptic transmission. A variety of pre- and postsynaptic actions of IL-1β were seen in five different electrophysiologically-defined neuronal phenotypes. In putative excitatory 'delay' neurons, cytokine treatment increased the amplitude of spontaneous EPSC's (sEPSC) and decreased the frequency of spontaneous IPSC's (sIPSC). These effects would be expected to increase dorsal horn excitability and to facilitate the transfer of nociceptive information. However, other actions of IL-1β included disinhibition of putative inhibitory 'tonic' neurons and an increase in the amplitude of sIPSC's in 'delay' neurons. Conclusion Since spinal microglial activation peaks between 3 and 7 days after the initiation of chronic peripheral nerve injury and these cells release IL-1β at this time, our findings define some of the neurophysiological mechanisms whereby nerve-injury induced release of IL-1β may contribute to the central sensitization associated with chronic neuropathic pain.
Application of a Novel AAV Gene Therapy: Investigating AAV6.2-FF in Models of Pulmonary Surfactant-Related Disease
Creators: name: Nangle, Kennedy
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Gene Therapy
Surfactant Disorders
AAV
Pulmonary Fibrosis

description: Surfactant proteins are a group of proteins responsible for maintaining a healthy lung by lowering surface tension in the alveoli and facilitating proper homeostasis of pulmonary surfactant components at the air-liquid interface. Surfactant protein B and C have been associated with disease as a result of genetic mutations disrupting the function of these critical proteins. Mutations in the Surfactant protein C gene (SFTPC) are known to cause Pulmonary Fibrosis (PF), a rare, chronic, lethal lung condition characterized by the build up of scar tissue in the pulmonary space. Mutations in the SFTPB gene are associated with a rare, lethal condition, SP-B deficiency. This condition presents neonatally and is characterized by respiratory distress and neonatal death within the first weeks of life. There are currently no treatments for either condition and lung transplantation is the only opportunity for a cure. The clear genetic etiology of both conditions offers the possibility of treatment through gene therapy. Recently, our lab has shown the potential of a novel viral vector gene therapy (AAV6.2-FF) for the treatment of SP-B deficiency, restoring expression of the Sftpb gene and extending the lifespan of SP-B deficient mice by over 300+ days compared to controls. Additionally, our lab has extended the use of this gene therapy platform for the treatment for Sftpc-related pulmonary fibrosis in a transgenic mouse model of the most common mutation (I73T) associated with the disease (manuscript in review). This thesis focuses on a potential therapy transfer of the Sftpc gene therapy to another common SFTPC mutation, L184Q. This thesis also addresses the characterization of re-administration of the AAV6.2-FF vector in Sftpb mice in order to expand on the potential clinical translation of the therapy. Both models were established and feasibility of the therapeutic expansion of these models was assessed. In the model of Sftpc-L184Q knock- in, the administration of bleomycin resulted in a significant increase in fibrosis, as measured by the Ashcroft-Hubner score, a significant change in lung structure, by proxy of the Mean Linear Intercept, and a significant decrease in lung function. Taken together, this demonstrates the successful development of injury in this mouse model. The administration of the AAV6.2-FF gene therapy resulted in a significant expression of the Sftpc transgene in the lung tissue of the L184Q mice, demonstrating the potential of the therapeutic in the L184Q model. Further studies assessing the combination of the injury model and administration of the therapeutic are required. A difference in phenotype between LQ and I73T mice was explored and investigations into this phenotype have laid the foundation for future exploration.
title: Sharing knowledge & fostering sustainable development
title: 45 years of scientific collaboration between the IRD and the Seychelles 1979 - 2024
titleType: Subtitle
Creators: name: Marsac, Francis
Publisher: name: Zenodo
Year: 2024

description: IRD celebrates its 80th anniversary in 2024, and 45 years of scientific collaboration with the Seychelles (1979 - 2024)
Stipiturus malachurus subsp. littleri Mathews 1912
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Maluridae
Stipiturus
Stipiturus malachurus
Stipiturus malachurus littleri mathews

description: Stipiturus malachurus littleri Mathews
 Stipiturus malachurus littleri Mathews, 1912a: 363 (Tasmania).
 Now Stipiturus malachurus littleri Mathews, 1912. See Schodde, 1982: 133, and Schodde and Mason, 1999: 101–103.
HOLOTYPE: AMNH 602975, adult male, collected in Tasmania, Australia, by R.H.W. Leach. From the Mathews Collection (no. 4582) via the Rothschild Collection.
 COMMENTS: Mathews cited his catalog number of the holotype in the original description. The specimen bears a Mathews type label, but no Rothschild type label. An AMNH type label has been added. There is one paratype: AMNH 602976 (Mathews no. 4581), female, collected in Tasmania also by Leach, according to the Mathews catalog. These are the only two specimens of littleri that came to AMNH with the Rothschild Collection.
Whittell (1954: 417) identified the collector as Richard H.W. Leach who made a collecting trip to Tasmania in 1863 and gave specimens to Mathews.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 114, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Indole alkaloids from Ochreinauclea maingayi (Rubiaceae) as butyrylcholinesterase inhibitors and their paralysis effect in transgenic Caenorhabditis elegans
Creators: name: Osman, Norfaizah
name: Awang, Khalijah
name: Khaw, Kooi Yeong
name: Mak, Wen Qi
name: Tiamas, Shelly Gapil
name: Maulana, Saipul
name: Zubair, Muhammad Sulaiman
name: Pudjiastuti, Pratiwi
name: Hazni, Hazrina
name: Liew, Sook Yee
name: Zahari, Azeana
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: This study investigated the butyrylcholinesterase (BChE) inhibitory activity of harmane (1), naucledine (2), and dihydrodeglycocadambine (3) isolated from fractions F7 and F9 of Ochreinauclea maingayi. Both fractions demonstrated significant inhibition, exceeding 80%, against BChE at 100 µg/mL. Compound 2, is the most potent inhibitor, exhibiting an IC50 value of 22.08 µM, followed by 1 and 3 (IC50 23.96 and 30.32 µM, respectively). Docking studies revealed that 1 and 2 effectively bind to BChE, with binding energies of −51.24 and −57.17 kcal/mol, respectively. Kinetic analysis of 2 indicated mixed-mode inhibition of BChE, with a Ki of 6.08 μM. In the paralysis assay, 1 showed a weak delay in paralysis and reduced the paralysis ratio from 72.59 ± 4.7% to 60.00 ± 7.0% (12.59% reduction) followed by 2 with 70.00 ± 1.7% (2.59% reduction) compared with negative standard (DMSO 0.1%) on human amyloid β-protein in a transgenic Caenorhabditis elegans (CL4176) model.
The Role of Temporal Distance in Young Children’s Future Event Representations and Reasoning
Creators: name: O'Brien, Bronwyn
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: cognitive development
episodic future thinking
event representation
reasoning
temporal distance

description: The current dissertation examines the effect of temporal distance on two aspects of children’s thinking: 1) future event representations (Study 1), and 2) reasoning (Study 2). Study 1 includes a series of three experiments that sought to determine the effects of temporal distance, age, and event frequency on children’s future event representations. Five- to 9-year-olds were asked to describe frequent (e.g., snack) and infrequent (e.g., party) events, with half of children imagining that these events would happen in the near future and the other half imagining that they would happen in the distant future. With several exceptions, effects of temporal distance were not detected, although event frequency (examined in Experiment 1) played an important role in children’s event representations. Results suggested that young children may begin perceiving differences in temporal distance, but that this does not translate to their event representations (e.g., clarity, use of personal pronouns) until later in development. Study 2 used a novel method to examine the impact of temporal distance on young children’s reasoning, while addressing important methodological limitations of Study 1 (i.e., reliance on verbal skills and self-projection). Three to 6-year-olds were asked to judge which of two characters felt more “happy”/“sad” right now: one engaging in a pleasant/unpleasant activity tomorrow or another engaging in this same activity when they are a year older. Starting at age 4, children correctly judged which child was more “happy”/“sad” right now. However, 4- to 6-year-olds tended not to explain their judgments by referring to temporal distance, per se. Similarly to Study 1, results suggest that children are sensitive to temporal distance early in development - perhaps earlier than previously thought - but do not yet verbally express this understanding. Taken together, this research contributes new insights to our understanding of the development of sensitivity to temporal distance in young children. Implications for theories about children’s future thinking and future areas of research are discussed.
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis
Creators: name: MacDonald, Marcia L. E.
name: Van Eck, Miranda
name: Hildebrand, Reeni B.
name: Wong, Brian W. C.
name: Bissada, Nagat
name: Ruddle, Piers
name: Kontush, Anatol
name: Hussein, Hala
name: Pouladi, Mahmoud A.
name: Chapman, M. John
name: Fievet, Catherine
name: Van Berkel, Theo J. C.
name: Staels, Bart
name: McManus, Bruce M.
name: Hayden, Michael R.
Publisher: name: American Heart Association
Year: 2009

description: OBJECTIVE—Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. The aim of this study was to determine the effect of SCD1 deficiency on atherosclerosis. Methods and RESULTS—Despite an antiatherogenic metabolic profile, SCD1 deficiency increases atherosclerosis in hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a western diet. Lesion area at the aortic root is significantly increased in males and females in two models of SCD1 deficiency. Inflammatory changes are evident in the skin of these mice, including increased intercellular adhesion molecule (ICAM)-1 and ulcerative dermatitis. Increases in ICAM-1 and interleukin-6 are also evident in plasma of SCD1-deficient mice. HDL particles demonstrate changes associated with inflammation, including, decreased plasma apoA-II and apoA-I and paraoxonase-1 and increased plasma serum amyloid A. Lipopolysaccharide-induced inflammatory response and cholesterol efflux are not altered in SCD1-deficient macrophages. In addition, when SCD1 deficiency is limited to bone-marrow derived cells, lesion size is not altered in LDLR-deficient mice. CONCLUSIONS—These studies reinforce the crucial role of chronic inflammation in promoting atherosclerosis, even in the presence of antiatherogenic biochemical and metabolic characteristics. [The original version of this article, along with updated information and services is located on the World Wide Web at: http://atvb.ahajournals.org/cgi/content/full/29/3/341] [UBC users: please click on the UBC eLink icon at the bottom of this record]
Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds
Creators: name: Krusir, Galyna
name: Pylypenko, Liudmyla
name: Sevastyanova, Elena
name: Mazurenko, Kseniia
name: Moshtakov, Serhii
name: Shunko, Hanna
name: Vitiuk, Antonina
name: Shpyrko, Tetyana
name: Zdoryk, Oleksandr
Publisher: name: Oles Honchar Dnipro National University
Year: 2023
Subjects: subject: 500 - Naturwissenschaften und Mathematik

description: Digestive enzymes and inhibitors of digestive enzymes are effective correctors of digestive processes in the body, the violation of which leads to various diseases (diabetes, hyperlipidemia, cardiovascular diseases, neoplasms and others). The present study identified the most promising plant objects characterized by the highest antilipolytic activity (ALA) in relation to pancreatic lipase. The experimental results indicate that the inhibitory activity (IA) of phenolic compounds of rapeseed is so much high and comparable to ALA "Orlistat", reaching 95.5 % of its activity. This determines the potential possibility of using the phenolic complex of rapeseed as an alternative to anti-lipolytic drugs of synthetic origin. The predominant component of the phenolic complex is low molecular weight phenolic compounds; polyphenolic compounds are almost equally represented by tannins – condensed and hydrolyzable. According to TLC data, the main components of low molecular weight phenols are glucopyranosylsinapate, sinapic acid and sinapin. Among the phenolic compounds of rapeseed seeds, sinapine and hydrolyzable tannins have the highest anti lipolytic activity against lipase. Significant ability to inhibit the action of pancreatic lipase is characterized by both low molecular weight and high molecular weight phenolic compounds of rapeseed.
Multiphase Computational Fluid Dynamics Modelling of Gas Liquid Separation in an Ebullated Bed Hydroprocessor
Creators: name: Evans, Katelyn
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Ebullated Bed Hydroprocessor
Cold-Flow Fluid Dynamics
Gas-Liquid Separator
Computational Fluid Dynamics Simulation
Gas Bubble Disengagement

description: This research built a multiphase computational fluid dynamics model for the gas-liquid separator in an ebullated bed hydroprocessor. The k-ω Shear Stress Transport turbulence model in conjunction with the Tomiyama slightly contaminated drag model were used to investigate gas-liquid separation efficiency. Strategic model selection ensures stable and accurate results, laying groundwork for future model comparisons incorporating inhomogeneous multiple size group population balance models. Case studies explore impacts of independent variables on separation efficiency, revealing that larger bubble size enhances separation by facilitating disengagement from liquid streamlines. Augmenting inlet gas phase fraction increases overall gas holdup, reduces mean liquid residence time and separation efficiency. A greater liquid momentum's effect on residence time is less pronounced but decreases separation efficiency. Viscosity inversely affects separation efficiency due to decreased relative velocities. Increasing liquid recycle ratio decreases separation efficiency by reducing mean liquid residence time. Mean liquid residence time emerges as a reliable predictor of separation efficiency, underscoring its significance in process optimization. Future inclusion of population balance models could provide insights into the impact of different bubble sizes and breakup/coalescence modeling, with validation challenges anticipated. Additionally, incorporating turbulence models accommodating phase inversion phenomena shows promise in improving simulation robustness, especially in complex scenarios like population balance models, warranting further investigation for accurate phase inversion dynamics capture.