cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Documents complémentaires de l'article "Protocole de fouille sur les sites paléolithiques : justification des besoins et modalités de mise en œuvre à Combe-Grenal et à l’abri inférieur du Moustier (Dordogne, France)"
title: Supplementary Material for the article "The “whys and hows” of data collection when designing fieldwork methods at Palaeolithic sites: the examples of Combe-Grenal and Le Moustier (Dordogne, France)"
Creators: name: Discamps, Emmanuel
name: Faivre, Jean-Philippe
name: Gravina, Brad
name: Thomas, Marc
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Documents complémentaires
#1 Détails des protocoles (.pdf)
#2 Page vierge du carnet des pièces coordonnées (exemple de Combe-Grenal) (.docx)
#3 Fiche de décapage vierge (exemple du Moustier), éditable dans un logiciel d’image (.pdf)
#4 Étiquettes d’objets pré-remplis (exemple du décapage 40 de la Zone B du Moustier), éditable dans un logiciel d’image (.pdf). Un “rechercher/remplacer” suffit à modifier rapidement le numéro de décapage et/ou les identifiants de carré/sous-carré.
#5 Étiquettes de seaux (exemple de Combe-Grenal), éditable dans un logiciel d’image (.pdf)
#6 Exemple d’enregistrement dans la BDD FileMaker TAMIS (.fmp12). Pour créer les étiquettes définitives des refus de tamis (cf. fig. 9), il faut : 1) à partir du modèle « THEO », importer tous les enregistrements de la BDD spatial dans la table « THEO », 2) à partir du modèle « Saisie », créer un enregistrement pour chaque seau avec son numéro unique (les informations d’année, de numéro de décapage et d’US sont récupérés automatiquement depuis la table « THEO »), puis sélectionner en « enregistrements trouvés » les seaux pour lesquels on souhaite imprimer des étiquettes (la case « Labels to print » a été implémentée pour faciliter cette opération), 3) enfin, à partir des modèles « Etiquettes », « EtiquettesMicro » ou « EtiquettesCharbon », lancer une impression pour obtenir un PDF avec toutes les étiquettes correspondantes aux seaux sélectionnés.
Decoupling the dynamic mechanism revealed by FGFR2 mutation-induced population shift
Creators: name: Zhang, Yuxiang
name: Yin, Xiao-Lan
name: Ji, Mingfei
name: Chen, Yi
name: Chai, Zongtao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: The fibroblast growth factor receptor 2 (FGFR2) is a key component in cellular signaling networks, and its dysfunctional activation has been implicated in various diseases including cancer and developmental disorders. Mutations at the activation loop (A-loop) have been suggested to trigger an increased basal kinase activity. However, the molecular mechanism underlying this highly dynamic process has not been fully understood due to the limitation of static structural information. Here, we conducted multiple, large-scale Gaussian accelerated molecular dynamics simulations of five (K659E, K659N, K659M, K659Q, and K659T) FGFR2 mutants at the A-loop, and comprehensively analyzed the dynamic molecular basis of FGFR2 activation. The results quantified the population shift of each system, revealing that all mutants had a higher proportion of active-like states. Using Markov state models, we extracted the representative structure of different conformational states and identified key residues related to the increased kinase activity. Furthermore, community network analysis showed enhanced information connections in the mutants, highlighting the long-range allosteric communication between the A-loop and the hinge region. Our findings may provide insights into the dynamic mechanism for FGFR2 dysfunctional activation and allosteric drug discovery. Communicated by Ramaswamy H. Sarma
Constructing a refined model of small bodies in the solar system - I. The Jovian Trojans
Creators: name: Li, Jian
name: Sun, Yi-Sui
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Aim. We construct a new arc model to represent the global perturbation induced by the Jupiter Trojans for the development of the modern planetary ephemerides. Methods. The Jupiter Trojans are divided into two groups: (1) the 226 biggest ones with absolute magnitudes $H<11$, have well determined masses and are treated as individual bodies; (2) the remaining small ones with $H\geqslant11$, are modeled by two discrete arcs centered at Jupiter's L4 and L5 points, respectively. Then we derived the parameters characterizing the arcs, such as the total mass, the mass ratio, and the spatial distributions. Uncertainties on the fitted parameters have also been taken into account. Results. We find that the total mass of all the Jupiter Trojans, including the undiscovered ones, is most likely about $1.861\times 10^{-5}$ Earth mass. Then the global perturbation of the trojan population induced on the Earth-Mars distance is numerically estimated to be about 70 m during the 2014-2114 time interval. We also give a simple analytic expression. For the satellites of Mars and Jupiter, however, the change of the distance between the Earth and a satellite can be much more significant, reaching on tens of thousands of meters over one century, due to perturbations of the Jupiter Trojans.
description: 10 pages, 13 figures, accepted by Astronomy & Astrophysics
Stegopterus septus Burmeister & Schaum 1840
Creators: name: Ricchiardi, Enrico
name: Perissinotto, Renzo
name: Strümpher, Werner
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Stegopterus
Stegopterus septus

description: Stegopterus septus Burmeister & Schaum, 1840
Fig. 17
Stegopterus septus Burmeister & Schaum, 1840: 406 (original description); Burmeister 1842: 745; Harold 1869: 1342; Péringuey 1907: 299; Schenkling 1922: 14; Krajčik 1999: 49.
Type material.
Lectotype, here designated. South Africa – WCP • ♂; Caffria; Schaum Type; Coll. Melly; MHNG: MHNG ENTO 0119900.
Other material examined.
South Africa – WCP • 1 ♂; Hott. Holl. Mts. [Hottentot-Holland Mountains], Steenbras, Nov. 1932; K. H. Barnard leg.; SAMC: SAM-COL-A 043575.
Diagnosis.
Stegopterus septus differs from S. lamellus sp. nov., the closest species, by its protibia being externally tridentate and exhibiting all three teeth equally spaced. Its mesotibia is bent ventrally and bears a lower spur much shorter than the upper one (about 30 %). Its antennal clubs are very long, about 2.1 × longer than the clypeal length.
Distribution.
Although the locality reported on the LT label specimen is far too general and equivocal, the available male from the Hottentots-Hollandberge sets the range of this species in the mountain area between the towns of Somerset West and Grabouw (Fig. 21).
Remarks.
The syntype preserved in the Melly Collection (MHNG, Fig. 17) and labelled “ Schaum Type ” was reported in Burmeister and Schaum (1840, p. 406) as preserved in Germar’s Collection. Burmeister (1842, p. 745) later specified that there were two males in Germar’s Collection but only one is labelled as “ Schaum Type ”. For this reason, the “ Schaum Type ” preserved in the MHNG, cannot be regarded as the holotype and is therefore designated here as a lectotype.
Péringuey (1907, p. 299) redescribed S. septus on the basis of a male collected in Clanwilliam (WCP), which he misidentified as such. That specimen is herein redescribed as the holotype of S. rotundiceps sp. nov. Péringuey (1907, p. 299) also reluctantly attributed a second specimen from Knysna to S. septus, but we were unable on this occasion to trace and analyse this specimen.
The species is very rare and among all the Stegopterus specimens studied, we could identify only two males belonging to S. septus. Females remain unknown.
description: Published as part of Ricchiardi, Enrico, Perissinotto, Renzo & Strümpher, Werner, 2025, Revision of the Western Cape endemic genus Stegopterus Burmeister & Schaum, 1840 (Coleoptera, Scarabaeidae, Cetoniinae, Trichiini), pp. 151-191 in African Invertebrates 66 (1) on pages 151-191, DOI: 10.3897/afrinvertebr.66.140593
Towards Socially Restorative Urbanism: Exploring Social and Spatial Implications for Urban Restorative Experience
Creators: name: Thwaites, Kevin
Publisher: name: Landscape Review
Year: 2012

description: This paper explores ideas that might help to stimulate new avenues of inquiry into how those involved in shaping the urban environment might begin to restore a better balance of human benefit and urban form in approaches to urban regeneration and design. At present, growing evidence suggests that our capability to create socially sustainable urban regeneration and design may be compromised by over-privileging economic interests and rapid delivery over social relevance. Particularly in mixed-use residential development, an important consequence may be that people experience less of a sense of control over their homes and neighbourhoods, which diminishes opportunities for territorial expressions important to life quality and social cohesion. The paper begins by discussing the concept of restorative environments and asserts that there are important social dimensions to human restorative experience, not yet widely investigated, that can be related to the form of towns and cities. We suggest that a better understanding of these environments can be found in phenomenological perspectives on human–environment relations. These perspectives provide foundations for more evolutionary approaches to urban morphology that raise questions around the balance of control between professional processes and user-modification in urban place making. Specifically identified and discussed are social processes that connect territorial expression with opportunities people have to develop and sustain self-esteem. The paper concludes by suggesting that new research directions in urbanism might productively explore the interface where the need to establish structurally stable infrastructure may gradually give way to more indeterminate and evolutionary processes of occupation and territorial negotiation.
description: Landscape Review, Vol 13 No 2 (2011): Landscape Review
Aspects of Nonrenormalizable Terms in a Superstring Derived Standard--like Model
Creators: name: Faraggi, Alon E.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I investigate the role of nonrenormalizable terms, up to order N=8, in a superstring derived standard--like model. I argue that nonrenormalizable terms restrict the gauge symmetry, at the Planck scale, to be $SU(3)\times SU(2)\times U(1)_{B-L}\times U(1)_{T_{3_R}}$ rather than $SU(3)\times SU(2)\times U(1)_Y$. I show that breaking the gauge symmetry directly to the Standard Model leads to breaking of supersymmetry at the Planck scale, or to dimension four, baryon and lepton violating, operators. I show that if the gauge symmetry is broken directly to the Standard Model the cubic level solution to the F and D flatness constraints is violated by higher order terms, while if $U(1)_{Z^\prime}$ remains unbroken at the Planck scale, the cubic level solution is valid to all orders of nonrenormalizable terms. I discuss the Higgs and fermion mass spectrum. I demonstrate that realistic, hierarchical, fermion mass spectrum can be generated in this model.
description: WIS--/92/48/JUN--PH, 28 pages
Non-LTE Calculations of the Fe I 6173 Å Line in a Flaring Atmosphere
Creators: name: Hong, Jie
name: Ding, M. D.
name: Li, Ying
name: Carlsson, Mats
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Fe I 6173 Å line is widely used in the measurements of vector magnetic fields by instruments including the Helioseismic and Magnetic Imager (HMI). We perform non-local thermodynamic equilibrium calculations of this line based on radiative hydrodynamic simulations in a flaring atmosphere. We employ both a quiet-Sun atmosphere and a penumbral atmosphere as the initial one in our simulations. We find that, in the quiet-Sun atmosphere, the line center is obviously enhanced during an intermediate flare. The enhanced emission is contributed from both radiative backwarming in the photosphere and particle beam heating in the lower chromosphere. A blue asymmetry of the line profile also appears due to an upward mass motion in the lower chromosphere. If we take a penumbral atmosphere as the initial atmosphere, the line has a more significant response to the flare heating, showing a central emission and an obvious asymmetry. The low spectral resolution of HMI would indicate some loss of information but the enhancement and line asymmetry are still kept. By calculating polarized line profiles, we find that the Stokes I and V profiles can be altered as a result of flare heating. Thus the distortion of this line has a crucial influence on the magnetic field measured from this line, and one should be cautious in interpreting the magnetic transients observed frequently in solar flares.
description: 12 pages, 5 figures, accepted by ApJL
Considering Ecological Imperatives in Public Open Space in
Creators: name: Grose, Margaret
Publisher: name: Landscape Review
Year: 2012

description: Public open space within the suburbanising South-west Australian Floristic Region is reviewed in this paper in relation to key ecological imperatives. Qualitative sources, quantitative research and professional practice are examined across science, planning and landscape architecture, with a focus on turf, water, species and retained bush. New relationships between turf and bush in public open spaces in designed suburban developments in this Mediterranean-type hotspot are outlined. Four types of public open space are distinguished, with a focus on ‘turf that works’ and the use of hydrozoning and ecozoning as new strategies in this hotspot. These strategies provide concurrent opportunities for water conservation and biodiversity, and are designed for resilience. This review positions these new strategies as an example of better design outcomes in public spaces as a result of improved translation of knowledge across the disciplines.
description: Landscape Review, Vol 13 No 2 (2011): Landscape Review
Discovering potential inhibitors of Raf proto-oncogene serine/threonine kinase 1: a virtual screening approach towards anticancer drug development
Creators: name: Khan, Afsha
name: Bealy, Mohamed Ahmed
name: Alharbi, Bandar
name: Khan, Shama
name: Alharethi, Salem Hussain
name: Abu Al-Soud, Waleed
name: Mohammad, Taj
name: Hassan, Md. Imtaiyaz
name: Alshammari, Nawaf
name: Al-Keridis, Lamya Ahmed
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology

description: Raf proto-oncogene serine/threonine kinase 1 (RAF1 or c-Raf) is a serine/threonine protein kinase crucial in regulating cell growth, differentiation, and survival. Any disruption or overexpression of RAF1 can result in neoplastic transformation and other disorders such as cardiomyopathy, Noonan syndrome, leopard syndrome, etc. RAF1 has been identified as a potential therapeutic target in drug development against various complex diseases, including cancer, due to its remarkable role in disease progression. Here, we carried out a multitier virtual screening study involving different in-silico approaches to discover potential inhibitors of RAF1. After applying the Lipinski rule of five, we retrieved all phytocompounds from the IMPPAT database based on their physicochemical properties. We performed a molecular docking-based virtual screening and got top hits with the best binding affinity and ligand efficiency. Then we screened out the selected hits using the PAINS filter, ADMET properties, and other druglike features. Eventually, PASS evaluation identifies two phytocompounds, Moracin C and Tectochrysin, with appreciable anti-cancerous properties. Finally, all-atom molecular dynamics simulation (MDS) followed by interaction analysis was performed on the elucidated compounds in complex with RAF1 for 200 ns to investigate their time-evolution dynamics and interaction mechanism. Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) and Dynamical Cross-Correlation Matrix (DCCM) analyses then followed these results from the simulated trajectories. According to the results, the elucidated compounds stabilize the RAF1 structure and lead to fewer conformational alterations. The results of the current study indicated that Moracin C and Tectochrysin could serve as potential inhibitors of RAF1 after required validation. Communicated by Ramaswamy H. Sarma
Large-Scale Mass Distribution Behind the Galactic Plane
Creators: name: Kolatt, Tsafrir
name: Dekel, Avishai
name: Lahav, Ofer
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We map the smoothed mass-density distribution in the Galactic zone of avoidance (zoa), within $6000\kms$ of the Local Group, using potent reconstruction from peculiar velocities of galaxies. The interpolation into the zoa is based on the assumed gravitational nature of the velocity field implying a potential flow. The main dynamical features at a distance r=4000 km/s are (a) the peak of the Great Attractor connecting Centaurus and Pavo at l=330, (b) a moderate bridge connecting Perseus-Pisces and Cepheus at l= 140, and (c) an extension of a large void from the southern Galactic hemisphere into the zoa near the direction of Puppis, l=220-270. We find a strong correlation between the mass density and the IRAS and optical galaxy density at $b=+-20, which indicates that the main dynamical features in the zoa should also be seen in galaxy surveys through the Galactic plane. The gravitational acceleration at the Local Group, based on the mass distribution out to 6000 km/s, is strongly affected by the mass distribution in the zoa: its direction changes by 31 when the |b| < 20 zoa is included, bringing it to within 4 +- 19 of the CMB dipole.
description: (10 pages, 8 figures, compressed and uudecoded PostScript 1.3Mbyte)
Blow-Up of Test Fields Near Cauchy Horizons
Creators: name: Rauch, J.
name: Rendall, A. D.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The behaviour of test fields near a compact Cauchy horizon is investigated. It is shown that solutions of nonlinear wave equations on Taub spacetime with generic initial data cannot be continued smoothly to both extensions of the spacetime through the Cauchy horizon. This is proved using an energy method. Similar results are obtained for the spacetimes of Moncrief containing a compact Cauchy horizon and for more general matter models.
description: 10 pages, Plain TeX, MPA-AR-92-1
Integrated molecular and quantum mechanical approach to identify novel potent natural bioactive compound against 2′-O-methyltransferase (nsp16) of SARS-CoV-2
Creators: name: Thomas, Jobin
name: Kumar, Sanjit
name: Satija, Jitendra
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: With the advent of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak, efforts are still in progress to find out a functional cure for the infection. Among the various protein targets, nsp16 capping protein is one of the vital targets for drug development as it protects the virus against the host cell nucleases and evading innate immunity. The nsp16 protein forms a heterodimer with a co-factor nsp10 and triggers 2′-O-methyltransferase activity which catalyzes the conversion of S-adenosyl methionine into S-adenosyl homocysteine. The free methyl group is transferred to the 2′-O position on ribose sugar at the 5′ end of mRNA to form the cap-1 structure which is essential for replication of the virus and evading the innate immunity of the host. In this study, we identify a potential lead natural bioactive compound against nsp16 protein by systematic cheminformatic analysis of more than 144k natural compounds. Virtual screening, molecular docking interactions, ADMET profiling, molecular dynamics (MD) simulations, molecular mechanics-generalized born surface area (MM-GBSA), free energy analysis and density functional theory analysis were used to discover the potential lead compound. Our investigation revealed that ZINC8952607 (methyl-[(6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)aminomethyl]BLAHone) has the greatest binding affinity and best pharmacokinetic parameters due to presence of carbazol and BLAHone (biaryl moiety). Further, time-dependent MD simulation analysis substantiates the stability and rigidness of nsp16 protein even after interaction with the lead compound. We believe that the compound ZINC8952607 might establish as a novel natural drug candidate against CoVID-19 infection. Communicated by Ramaswamy H. Sarma
Construction of Realistic Standard--like Models in the Free Fermionic Superstring Formulation
Creators: name: Faraggi, Alon E.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I discuss in detail the construction of realistic superstring standard--like models in the four dimensional free fermionic formulation. The analysis results in a restricted class of models with unique characteristics: (i) Three and only three generations of chiral fermions with their superpartners and the correct Standard Model quantum numbers. (ii) Proton decay from dimension four and dimension five operators is suppressed due to gauged $U(1)$ symmetries. (iii) There exist Higgs doublets from two distinct sectors, which can generate realistic symmetry breaking. (iv) These models explain the top--bottom mass hierarchy. At the trilinear level of the superpotential only the top quark gets a non vanishing mass term. The bottom quark and the lighter quarks and leptons get their mass terms from non renormalizable terms. This result is correlated with the requirement of a supersymmetric vacuum at the Planck scale. (v) The models predict the existence of small hidden gauge groups, like $SU(3)$, with matter spectrum in vector representations.
description: 28 pages
Causality in Strong Shear Flows
Creators: name: Narayan, Ramesh
name: Loeb, Abraham
name: Kumar, Pawan
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: It is well known that the standard transport equations violate causality when gradients are large or when temporal variations are rapid. We derive a modified set of transport equations that satisfy causality. These equations are obtained from the underlying Boltzmann equation. We use a simple model for particle collisions which enables us to derive moment equations non-perturbatively, i.e. without making the usual assumption that the distribution function deviates only slightly from its equilibrium value. We apply the model to two problems: particle diffusion and viscous transport. In both cases we show that signals propagate at a finite speed and therefore that the formalism obeys causality. When the velocity gradient is large on the scale of a mean free path, the viscous shear stress is suppressed relative to the prediction of the standard diffusion approximation. The shear stress reaches a maximum at a finite value of the shear amplitude and then decreases as the velocity gradient increases. In the case of a steady Keplerian accretion disk with hydrodynamic turbulent viscosity, the stress-limit translates to an upper bound on the Shakura-Sunyaev $α$-parameter, namely $α<0.07$. The limit on $α$ is much stronger in narrow boundary layers where the velocity shear is larger than Keplerian.
description: 44 pages, TEX, 9 figures can be obtained from hottle@cfa.harvard.edu
Additional file 6: of Echocardiographic parameters and renal outcomes in patients with preserved renal function, and mild- moderate CKD
Creators: name: Mavrakanas, Thomas
name: Khattak, Aisha
name: Karandeep Singh
name: Charytan, David
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: Table S6. Echocardiographic characteristics of patients without CHF at baseline (DOCX 16 kb).
MOESM4 of Mapping visuospatial attention: the greyscales task in combination with repetitive navigated transcranial magnetic stimulation
Creators: name: Giglhuber, Katrin
name: Maurer, Stefanie
name: Zimmer, Claus
name: Meyer, Bernhard
name: Krieg, Sandro
Publisher: name: figshare
Year: 2018
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Raw data per cortical spot for the right hemisphere. Results for stimulation of the right hemisphere. Raw data of each subject. Number of effective stimulations, “leftward” answers and “rightward” answers. Outline per cortical spot (no. 1–52) plus mean, standard deviation (SD), minimum (MIN), and maximum (MAX).
Geometric Phase in Vacuum Instability:APPLICATIONS in Quantum Cosmology
Creators: name: Datta, D. P.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Three different methods viz. i) a perturbative analysis of the Schrödinger equation ii) abstract differential geometric method and iii) a semiclassical reduction of the Wheeler-Dewitt equation, relating Pancharatnam phase to vacuum instability are discussed. An improved semiclassical reduction is also shown to yield the correct zeroth order semicalssical Einstein equations with backreaction. This constitutes an extension of our earlier discussions on the topic
description: 12 Pages, Plain TeX, IUCAA-18/93
The Functional Integral for a Free Particle on a Half-Plane
Creators: name: Carreau, Michel
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A free non-relativistic particle moving in two dimensions on a half-plane can be described by self-adjoint Hamiltonians characterized by boundary conditions imposed on the systems. The most general boundary condition is parameterized in terms of the elements of an infinite-dimensional matrix. We construct the Brownian functional integral for each of these self-adjoint Hamiltonians. Non-local boundary conditions are implemented by allowing the paths striking the boundary to jump to other locations on the boundary. Analytic continuation in time results in the Green's functions of the Schrodinger equation satisfying the boundary condition characterizing the self-adjoint Hamiltonian.
description: 16 pages
Finite Source Sizes and the Information Content of MACHO-Type Lens Search Light Curves
Creators: name: Nemiroff, Robert J.
name: Wickramasinghe, W. A. D. Thulsi
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: If the dark halo matter is primarily composed of MACHOs toward the lower end of the possible detection range ($ < 10^{-3}$ $M_{\odot}$) a fraction of the lens detection events should involve the lens crossing directly in front of the disk of the background star. Previously, Nemiroff (1987) has shown that each crossing would create an inflection point in the light curve of the MACHO event. Such inflection points would allow a measure of the time it took for the gravitational lens to cross the stellar disk. Given an independent estimate of the stellar radius by other methods, one could then obtain a more accurate estimate of the velocity of the lens. This velocity could then, in turn, be used to obtain a more accurate estimate of the mass range for the MACHO or disk star doing the lensing.
description: in press: ApJ (Lett.), 10 pages in Plain TeX version 3.0, 1 figure available by FAX
Current correlators to all orders in the quark masses
Creators: name: Jamin, M.
name: Muenz, M.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The contributions to the coefficient functions of the quark and the mixed quark-gluon condensate to mesonic correlators are calculated for the first time to all orders in the quark masses, and to lowest order in the strong coupling constant. Existing results on the coefficient functions of the unit operator and the gluon condensate are reviewed. The proper factorization of short- and long-distance contributions in the operator product expansion is discussed in detail. It is found that to accomplish this task rigorously the operator product expansion has to be performed in terms of non-normal-ordered condensates. The resulting coefficient functions are improved with the help of the renormalization group. The scale invariant combination of dimension 5 operators, including mixing with the mass operator, which is needed for the renormalization group improvement, is calculated in the leading order.
description: 24 pages, LateX file, TUM-T31-21/92, 1 postscript file included
title: ADCO, Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Cart. 198-01 (11 H 1055), 185 folios, f. 0242
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0242, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0242, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19
Creators: name: Gutti, Gopichand
name: He, Yiran
name: Coldren, William H.
name: Lalisse, Remy F.
name: Border, Sarah E.
name: Hadad, Christopher M.
name: McElroy, Craig A.
name: Ekici, Özlem Doğan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: COVID-19, the disease responsible for the recent pandemic, is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main protease (Mpro) of SARS-CoV-2 is an essential proteolytic enzyme that plays a number of important roles in the replication of the virus in human host cells. Blocking the function of SARS-CoV-2 Mpro offers a promising and targeted, therapeutic option for the treatment of the COVID-19 infection. Such an inhibitory strategy is currently successful in treating COVID-19 under FDA’s emergency use authorization, although with limited benefit to the immunocompromised along with an unfortunate number of side effects and drug-drug interactions. Current COVID vaccines protect against severe disease and death but are mostly ineffective toward long COVID which has been seen in 5–36% of patients. SARS-CoV-2 is a rapidly mutating virus and is here to stay endemically. Hence, alternate therapeutics to treat SARS-CoV-2 infections are still needed. Moreover, because of the high degree of conservation of Mpro among different coronaviruses, any newly developed antiviral agents should better prepare us for potential future epidemics or pandemics. In this paper, we first describe the design and computational docking of a library of novel 188 first-generation peptidomimetic protease inhibitors using various electrophilic warheads with aza-peptide epoxides, α-ketoesters, and β-diketones identified as the most effective. Second-generation designs, 192 compounds in total, focused on aza-peptide epoxides with drug-like properties, incorporating dipeptidyl backbones and heterocyclic ring motifs such as proline, indole, and pyrrole groups, yielding 8 hit candidates. These novel and specific inhibitors for SARS-CoV-2 Mpro can ultimately serve as valuable alternate and broad-spectrum antivirals against COVID-19. Communicated by Ramaswamy H. Sarma
MOESM4 of Whole-genome SNP analysis elucidates the genetic structure of Russian cattle and its relationship with Eurasian taurine breeds
Creators: name: Sermyagin, Alexander
name: Dotsev, Arsen
name: Gladyr, Elena
name: Traspov, Alexey
name: Deniskova, Tatiana
name: Kostyunina, Olga
name: Reyer, Henry
name: Wimmers, Klaus
name: Barbato, Mario
name: Paronyan, Ivan
name: Plemyashov, Kirill
name: SĂślkner, Johann
name: Popov, Ruslan
name: Brem, Gottfried
name: Zinovieva, Natalia
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 4: Figure S2. Trend in slope changes of historical effective population size (Ne). This graph shows the trend in slope changes of the historical effective population size (Ne) for the period starting approximately 70 generations ago. For the full definition of breeds, see Table S1 [see Additional file 1: Table S1].
Evolution of Late-type Galaxies in a Cluster Environment: Effects of High-speed Multiple Encounters with Early-type Galaxies
Creators: name: Hwang, Jeong-Sun
name: Park, Changbom
name: Banerjee, Arunima
name: Hwang, Ho Seong
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Late-type galaxies falling into a cluster would evolve being influenced by the interactions with both the cluster and the nearby cluster member galaxies. Most numerical studies, however, tend to focus on the effects of the former with little work done on those of the latter. We thus perform a numerical study on the evolution of a late-type galaxy interacting with neighboring early-type galaxies at high speed, using hydrodynamic simulations. Based on the information obtained from the Coma cluster, we set up the simulations for the case where a Milky Way-like late-type galaxy experiences six consecutive collisions with twice as massive early-type galaxies having hot gas in their halos at the closest approach distances of 15-65 kpc/h at the relative velocities of 1500-1600 km/s. Our simulations show that the evolution of the late-type galaxy can be significantly affected by the accumulated effects of the high-speed multiple collisions with the early-type galaxies, such as on cold gas content and star formation activity of the late-type galaxy, particularly through the hydrodynamic interactions between cold disk and hot gas halos. We find that the late-type galaxy can lose most of its cold gas after the six collisions and have more star formation activity during the collisions. By comparing our simulation results with those of galaxy-cluster interactions, we claim that the role of the galaxy-galaxy interactions on the evolution of late-type galaxies in clusters could be comparable with that of the galaxy-cluster interactions, depending on the dynamical history.
description: 15 pages, 11 figures. ApJ in press
On time and the quantum-to-classical transition in Jordan-Brans-Dicke quantum gravity
Creators: name: Kiefer, Claus
name: Martinez, Erik A.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Any quantum theory of gravity which treats the gravitational constant as a dynamical variable has to address the issue of superpositions of states corresponding to different eigenvalues. We show how the unobservability of such superpositions can be explained through the interaction with other gravitational degrees of freedom (decoherence). The formal framework is canonically quantized Jordan-Brans-Dicke theory. We discuss the concepts of intrinsic time and semiclassical time as well as the possibility of tunneling into regions corresponding to a negative gravitational constant. We calculate the reduced density matrix of the Jordan-Brans-Dicke field and show that the off-diagonal elements can be sufficiently suppressed to be consistent with experiments. The possible relevance of this mechanism for structure formation in extended inflation is briefly discussed.
description: 10 pages, Latex, ZU-TH 15/93, BUTP-93/15
Targeting Aberrant Transcription in Invasive Lobular Carcinoma Breast Cancer
Creators: name: Walsh, Louise
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Invasive lobular carcinoma (ILC) is an understudied breast cancer subtype comprising 8-14% of breast tumours. The majority of ILC (90%) are estrogen receptor (ER)-positive and candidates for endocrine therapy. Unfortunately, de novo resistance to endocrine therapies occurs in 33% of women and a further 40% will relapse on treatment. Therefore, novel therapeutic targets are required for ILC. Deregulated transcription is a recurring theme in cancer, which can be due to epigenetic events. The bromodomain & extra-terminal domain (BET) family of proteins (BRD2, BRD3, BRD4, BRDT) function as chromatin readers that bind acetylated lysine residues on histones and regulate transcription. RNA sequencing analysis was performed on 61 primary ILC samples and it was found that high expression of BRD3 was associated with poor survival in ILC (log rank test, p=0.037). This finding was validated in a second cohort of 99 ILC primary samples from the METABRIC dataset (log rank test, p=0.0157). Next, it was tested if ILC cell lines were sensitive to BET inhibition using the small molecule inhibitor JQ1, which inhibits all BET family proteins. JQ1 downregulated growth promoting genes in ILC cell lines including ER and MYC. JQ1 inhibited cell growth in all ILC cell lines tested, however apoptosis was only induced in two out of four ILC cell lines. ILC cell lines resistant to JQ1-induced apoptosis had sustained or upregulated expression of the anti-apoptotic BCL-XL following JQ1 treatment by RNA sequencing and qPCR validation. This led us to assess the combination of JQ1 and ABT-263 (BCL-2, BCL-XL and BCL-W inhibitor). The drug combination was synergistic in ILC cell lines and induced apoptosis in ILC cell lines previously apoptotic resistant. The drug combination also inhibited the number and size of 3D spheroids and induced apoptosis in a ILC primary sample grown ex vivo. These findings suggest that the combination of JQ1 and ABT-263 is an effective treatment strategy for ILC.
Detecting superconductivity in the high pressure hydrides and metallic hydrogen from optical properties
Creators: name: Carbotte, J. P.
name: Nicol, E. J.
name: Timusk, T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present a new technique for measuring the critical temperature Tc in the high pressure, high Tc electron-phonon-driven superconducting hydrides. This technique does not require connecting leads to the sample. In the multiphonon region of the absorption spectrum, the reflectance mirrors the temperature variation of the superconducting order parameter. For an appropriately chosen value of photon energy of order twice the gap plus 1.5 times the maximum phonon energy, the temperature dependence of the reflectance varies much more rapidly below T=Tc than above. It increases with increasing temperature in the superconducting state while it decreases in the normal state. Examining the temperature dependence of the reflectance at a fixed photon energy, there is a cusp at T=Tc which provides a measurement of the critical temperature. We discuss these issues within the context of the recently observed metallic phase of hydrogen.
description: (5 pages, 5 figures)
Additional file 5: of Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India
Creators: name: Ranjita Das
name: Wahengbam Romi
name: Rictika Das
name: Hridip Sharma
name: Debajit Thakur
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Figure S3. â Chemical structures of metabolites present in PWS52 extract analyzed through GC-MS.â (PDF 1535 kb)
Stegopterus suturalis
Creators: name: Ricchiardi, Enrico
name: Perissinotto, Renzo
name: Strümpher, Werner
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Stegopterus
Stegopterus suturalis

description: Stegopterus suturalis (Gory & Percheron, 1833)
Fig. 18
Trichius suturalis Gory & Percheron, 1833: 84 (original description).
Trichius (Tetrophthalmi) suturalis: Kirby 1827: 156 [see comments in Smith 2004: 287 and Smith 2005: 75].
Stegopterus suturalis: Burmeister and Schaum 1840: 405; Burmeister 1842: 745; Harold 1869: 1342; Péringuey 1907: 298; Schenkling 1922: 14; Krajčik 1999: 49; Smith 2004: 288; Smith 2005: 75.
Type material.
Lectotype, here designated. South Africa – WCP • ♂; Cap. B. sp.; Gory Type; Coll. Melly; MHNG: MHNG ENTO 0119901.
Other material examined.
South Africa – WCP • 1 ♂; Cape; TMSA • 5 ♂; Cape Point; 23 Oct. 1973; N. J. Duke leg.; SANC • 1 ♂; same data as for preceding; ERPC • 2 ♂; Claremont; 1883 (?); H. W. Vakead leg.; SANC • 1 ♂; Hermanus; Jan. 1938; SANC • 2 ♀; Kirstenbosch C. P.; 23 Nov. 1964; A. L. Carpenter leg.; SANC • 1 ♂ 1 ♀; Stellenbosch, Nov. 87; L. I. leg.; SANC • 1 ♂; Table Mt., Cape Town; 27 Nov. 1921; A. L. Bevis leg.; TMSA • 1 ♂; Table Mts; Hiasterfemch leg.; SANC • 1 ♀; Yzerfontein; ERPC.
Diagnosis.
Stegopterus suturalis differs from S. paardebergi sp. nov., the closest species, by having the anterior corner of its clypeus rounded (about 40–55 % of clypeal length) and the lateral margins strongly reborded and slightly narrowing towards base. Its antennal clubs are as long as the clypeus.
Distribution.
Together with S. vittatus, this is the species that exhibits the largest distribution range and is the most numerous in collections, among all the species of the genus. Its range spans from Hermanus in the south-east to Yzerfontein in the north-west and includes the entire lowland region of the Cape Peninsula and parts of the adjacent Overberg and Swartland regions (Fig. 21).
Remarks.
The Gory Type is preserved in Geneva in the Melly Collection (MHNG). The male is here designated as the lectotype. A male in ERPC differs from the lectotype by having the elytra of a brick-red background colour with the black sutural band lacking the green hue. The female from Yzerfontein, in addition to being stouter than the others and having tridentate protibiae and short clubs, also has identical metallic green reflection. However, its elytra are dark testaceous, and the clypeus is similar to that of the male, but more hollowed anteriorly with a humped, convex forehead.
description: Published as part of Ricchiardi, Enrico, Perissinotto, Renzo & Strümpher, Werner, 2025, Revision of the Western Cape endemic genus Stegopterus Burmeister & Schaum, 1840 (Coleoptera, Scarabaeidae, Cetoniinae, Trichiini), pp. 151-191 in African Invertebrates 66 (1) on pages 151-191, DOI: 10.3897/afrinvertebr.66.140593
title: Source salée - Archives départementales de la Côte-d'Or, B 11199 0002
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: LaMOP
subject: Laboratoire de médiévistique occidentale de Paris

description: Reconnaissance d’une source salée à Tourmont, vers Poligny, par deux officiers ducaux
Document transcrit dans le cadre des ateliers de paléographie du Chancelier Rolin des Archives départements des Côtes d’Or
Page : 2/6
description: Source: https://archives.cotedor.fr/v2/site/AD21/web/media/04_apprendre/02_ateliers_chancelier_rolin/paleographie/intermediaires/2009_2010/document_04.pdf
description: Source: https://www.nakala.fr/10.34847/nkl.a7b3j72i
description: Source salée - Archives départementales de la Côte-d'Or, B 11199 0002