cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Composition of essential oil from the bark and leaves of two morphotypes of Salmea scandens (Asteraceae), a medicinal plant in Oaxaca, Mexico
Creators: name: García-Sánchez, Edgar
name: Solano, Rodolfo
name: Maciel-Amador, Olivia
name: Lagunez-Rivera, Luicita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Plant Biology

description: The chemical composition of the essential oils (EOs) from leaves and bark of two morphotypes, white (WM) and black (BM) of Salmea scandens obtained by microwave-assisted extraction (MAE) were analyzed by GC-MS. The major components of the bark EOs were aliphatic hydrocarbons (38.0% in WM, 48.6% in BM) and oxygenated sesquiterpenes (27.6% in WM, 11.3% in BM); in leaves EOs major components were oxygenated sesquiterpenes (43.9% in WM, 45.7% in BM) and oxygenated aliphatics (13.7% in WM, 1.1% in BM) stood out. Nine components have been reported to have antimicrobial and anti-inflammatory potential. The agglomerative hierarchical clustering and principal component analysis confirmed the variability of the EOs. These results suggest that WM may have a better therapeutic effect for treating infectious and inflammatory processes in traditional medicine.
Interleukin-6 Increases Rat Metalloproteinase-13 Gene Expression through Stimulation of Activator Protein 1 Transcription Factor in Cultured Fibroblasts
Creators: name: Muñoz-Yagüe, Teresa
name: García, Inmaculada
name: Rippe, Richard A.
name: Schrum, Laura W.
name: Solís-Herruzo, José A.
name: Brenner, David A.
name: De La Torre, Paz
name: Jeffrey, John J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The role of IL-6 in collagen production and tissue remodeling is controversial. In Rat-1 fibroblasts, we measured the effect of IL-6 on matrix metalloproteinase-13 (MMP-13), c-jun, junB, and c-fos gene expression, binding of activator protein 1 (AP1) to DNA, amount of AP1 proteins, immunoreactive MMP-13 and TIMP-1 proteins, and Jun N-terminal kinase activity. We show that IL-6 increased MMP-13-mRNA and MMP-13 protein. These effects were exerted by acting on the AP1-binding site of the MMP-13 promoter, as shown by transfecting cells with reporter plasmids containing mutations in this element. Mobility shift assays demonstrated that IL-6 induced the DNA binding activity of AP1. This effect was accompanied by a marked increase in c-Jun, JunB, and c-Fos mRNA, as well as in c-Jun protein and its phosphorylated form. The latter is not due to increased Jun N-terminal kinase activity but to a decreased serine/threonine phosphatase activity. We conclude that IL-6 increases interstitial MMP-13 gene expression at the promoter level. This effect seems to be mediated by the induction of c-jun, junB, and c-fos gene expression, by the binding of AP1 to DNA, by increasing phosphorylated c-Jun, and by the inhibition of serine/threonine phosphatase activity. These effects of IL-6 might contribute to remodeling connective tissue.
(1928) John Flower
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A numerical study of the 3D random interchange and random loop models
Creators: name: Barp, Alessandro
name: Barp, Edoardo Gabriele
name: Briol, Francois-Xavier
name: Ueltschi, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 60K35, 82B20, 82B26

description: We have studied numerically the random interchange model and related loop models on the three-dimensional cubic lattice. We have determined the transition time for the occurrence of long loops. The joint distribution of the lengths of long loops is Poisson-Dirichlet with parameter 1 or 1/2.
description: 11 pages
Mechanisms of Protection of Catalase by NADPH: KINETICS AND STOICHIOMETRY
Creators: name: Kirkman, Henry N.
name: Ferraris, Anna M.
name: Gaetani, Gian F.
name: Rolfo, Michela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: NADPH is known to be tightly bound to mammalian catalase and to offset the ability of the substrate of catalase (H2O2) to convert the enzyme to an inactive state (compound II). In the process, the bound NADPH becomes NADP+ and is replaced by another molecule of NADPH. This protection is believed to occur through electron tunneling between NADPH on the surface of the catalase and the heme group within the enzyme. The present study provided additional support for the concept of an intermediate state of catalase, through which NADPH serves to prevent the formation (rather than increase the removal) of compound II. In contrast, the superoxide radical seemed to bypass the intermediate state since NADPH had very little ability to prevent the superoxide radical from converting catalase to compound II. Moreover, the rate of NADPH oxidation was several times the rate of compound II formation (in the absence of NADPH) under a variety of conditions. Very little NADPH oxidation occurred when NADPH was exposed to catalase, H2O2, or the superoxide radical separately. That the ratio exceeds 1 suggests that NADPH may protect catalase from oxidative damage through actions broader than merely preventing the formation of compound II.
title: Spektrogrammanalyse zur Erkennung außerirdischer Signale mittels Convolutional und Recurrent Neural Networks
Creators: name: Cares, Tim
Publisher: name: Hochschule Hannover
Year: 2022
Subjects: subject: 004 Informatik

description: Bis heute ist völlig unbekannt, ob wir allein im Universum sind. Um auf dieses Thema eine Antwort zu finden, überprüft diese Bachelorarbeit, ob Convolutional (CNN) und Recurrent Neural Networks (RNN) für die Erkennung außerirdischer Signale geeignet sind. Das Ziel war dabei, in einem Datensatz bestehend aus Spektrogrammen mehr als 50% aller außerirdischer Signale zu erkennen, da nur so ein Neuronales Netzwerk ein besseres Resultat als eine zufällige Klassifikation liefert, bei der im Mittel 50% aller Signale erkannt werden. Dabei zeigte sich, dass sich mit beiden Varianten der Neuronalen Netzwerke bis zu 90% aller Signale erkennen lassen, die Vorhersagen von CNNs allerdings verlässlicher sind. RNNs bieten hingegen aufgrund ihrer geringeren Größe einen deutlich leichtgewichtigeren Ansatz und führen zu einer signifikanten Speicherersparnis. Daraus folgt, dass Neuronale Netzwerke bei der Suche nach außerirdischem Leben im Universum helfen können, um die Frage „Sind wir allein im Universum?“ endgültig zu beantworten.
Why Are We Doing This? Enhancing Curriculum with Career Readiness Toolkit
Creators: name: Chiru, Elena
name: Lindsey, Rachel
Publisher: name: Innovations in Teaching & Learning Conference Proceedings
Year: 2018
Subjects: active learning; student engagement; critical thinking

description: BRIEF SESSION DESCRIPTION:

University Career Services has created a comprehensive toolkit for faculty to enhance courses with career readiness components such as: learning support activities, assessments and rubrics, and educational materials. Â This session will demonstrate how to select the right tools to create customized connections between your course learning outcomes and the competencies that employers demand of successful candidates. Â It will also provide the language to share with your students to empower them to articulate the skills they develop through your existing course assignments. Â Participants will be able to effectively communicate to students the connections between their existing course content with career readiness skills employers seek to help prepare students for the job market regardless of discipline.

______________________________________________________________

FULL ABSTRACT:

This session will demonstrate to faculty ways to use the toolkit to make career-relevant skills developed within their courses clearer to students, and to help students market themselves as career-ready using knowledge gained through academic experience. "Translating your learning into skills for the job search" is a hands-on workshop-style set of activities that encourages students to identify the career-relevant skills they have been developing and demonstrating in class. Students are also guided through the process of articulating these skills in resume and during job interview.Â

Participants will be able to use provided (and tested) activities, effective strategies and templates that you can implement today to facilitate studentsâ€™ connections between their academic experience and their career goals.
description: Innovations in Teaching & Learning Conference Proceedings, Vol 10 (2018): Small Changes, Big Impact: 10 Years of ITL
Advancing Double Star Studies in an Age of Space-Based Astrometric Missions
Creators: name: Letchford, Roderick R.
Publisher: name: University of Southern Queensland
Year: 2022
Subjects: astrometry, visual binaries, stellar kinematics, celestial mechanics

description: The astrometric study of double stars is over 200 years old, and historically it has been a driver of stellar astrophysics resulting in the determination of the properties of stars, as well as formation and evolution models. Modern, space-based astronomy, from missions such as HIPPARCOS and Gaia, has opened a new sophisticated avenue of binary star studies. These space missions give the astrometric measures of a double star, its angular separation in arcseconds and position angle in degrees, with precisions that are 3 to 4 orders of magnitude more precise than has been available todate from single-aperture ground observations. In this thesis, Paper 1 crossmatches the double stars from the first published catalogue of double stars in the southern hemisphere (the Dunlop Catalogue) with the Gaia Data Release 2 (Gaia DR2) from the Gaia space-based mission and estimates the accuracy of the measures in the Dunlop Catalogue. Overall position angles are within 70°'/separation', separations within 7%, and apparent visual magnitudes are within 1 mag. Paper 2 develops an iteration-based technique for the determination of the first order orbital elements for long period and under-sampled arcs. This technique is then applied to a sample of binary stars from the Dunlop Catalogue. Orbital elements with a mean period and semi-major axis of ~81,000 years and ~76' respectively, were calculated displaying a mean uncertainty of ~37%. Paper 3 confirms the presence of 14 optical double stars within the Dunlop Catalogue and presents and applies an upgraded technique for calculating their rectilinear elements. This upgraded technique results in a minimum one order of magnitude improvement in their one sigma uncertainties over the current method.
(1929) Elizabeth [Flower]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Training, familiarization, tables ans figures from Long-tailed macaques (Macaca fascicularis) can use simple heuristics but fail at drawing statistical inferences from populations to samples
Creators: name: Placì, Sarah
name: Eckert, Johanna
name: Rakoczy, Hannes
name: Fischer, Julia
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Description of the training and familiarization phases as well as some additional tables ans figures
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
Creators: name: Quilliam, Lawrence A.
name: Der, Channing J.
name: Bi, Chen
name: Martin, Carol B.
name: Rogers-Graham, Kelley S.
name: Castro, Ariel F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: M-Ras is a Ras-related protein that shares approximately 55% identity with K-Ras and TC21. The M-Ras message was widely expressed but was most predominant in ovary and brain. Similarly to Ha-Ras, expression of mutationally activated M-Ras in NIH 3T3 mouse fibroblasts or C2 myoblasts resulted in cellular transformation or inhibition of differentiation, respectively. M-Ras only weakly activated extracellular signal-regulated kinase 2 (ERK2), but it cooperated with Raf, Rac, and Rho to induce transforming foci in NIH 3T3 cells, suggesting that M-Ras signaled via alternate pathways to these effectors. Although the mitogen-activated protein kinase/ERK kinase inhibitor, PD98059, blocked M-Ras-induced transformation, M-Ras was more effective than an activated mitogen-activated protein kinase/ERK kinase mutant at inducing focus formation. These data indicate that multiple pathways must contribute to M-Ras-induced transformation. M-Ras interacted poorly in a yeast two-hybrid assay with multiple Ras effectors, including c-Raf-1, A-Raf, B-Raf, phosphoinositol-3 kinase delta, RalGDS, and Rin1. Although M-Ras coimmunoprecipitated with AF6, a putative regulator of cell junction formation, overexpression of AF6 did not contribute to fibroblast transformation, suggesting the possibility of novel effector proteins. The M-Ras GTP/GDP cycle was sensitive to the Ras GEFs, Sos1, and GRF1 and to p120 Ras GAP. Together, these findings suggest that while M-Ras is regulated by similar upstream stimuli to Ha-Ras, novel targets may be responsible for its effects on cellular transformation and differentiation.
On optical spectroscopy of molecular junctions
Creators: name: Galperin, Michael
name: Ratner, Mark A.
name: Nitzan, Abraham
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We compare theoretical techniques utilized for description of optical response in molecular junctions, and their application to simulate Raman spectroscopy in such systems. Strong and weak sides of the Hilbert vs. Liouville space, as well as quasiparticles vs. many-body states, formulations are discussed. Common origins of the methodologies and different approximations utilized in different formulations are identified.
description: 17 pages, 4 figures
String theories as the adiabatic limit of Yang-Mills theory
Creators: name: Popov, Alexander D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider Yang-Mills theory with a matrix gauge group $G$ on a direct product manifold $M=Σ_2\times H^2$, where $Σ_2$ is a two-dimensional Lorentzian manifold and $H^2$ is a two-dimensional open disc with the boundary $S^1=\partial H^2$. The Euler-Lagrange equations for the metric on $Σ_2$ yield constraint equations for the Yang-Mills energy-momentum tensor. We show that in the adiabatic limit, when the metric on $H^2$ is scaled down, the Yang-Mills equations plus constraints on the energy-momentum tensor become the equations describing strings with a worldsheet $Σ_2$ moving in the based loop group $ΩG=C^\infty (S^1, G)/G$, where $S^1$ is the boundary of $H^2$. By choosing $G=R^{d-1, 1}$ and putting to zero all parameters in $ΩR^{d-1, 1}$ besides $R^{d-1, 1}$, we get a string moving in $R^{d-1, 1}$. In arXiv:1506.02175 it was described how one can obtain the Green-Schwarz superstring action from Yang-Mills theory on $Σ_2\times H^2$ while $H^2$ shrinks to a point. Here we also consider Yang-Mills theory on a three-dimensional manifold $Σ_2\times S^1$ and show that in the limit when the radius of $S^1$ tends to zero, the Yang-Mills action functional supplemented by a Wess-Zumino-type term becomes the Green-Schwarz superstring action.
description: 11 pages, v3: clarifying remarks added, new section on embedding of the Green-Schwarz superstring into d=3 Yang-Mills theory included
Mutagenesis Reveals a Role for Epidermal Growth Factor Receptor Extracellular Subdomain IV in Ligand Binding
Creators: name: Saxon, Marian L.
name: Lee, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The extracellular domain of the epidermal growth factor (EGF) receptor (EGFR) comprises four subdomains (I-IV) and mediates binding of several different polypeptide ligands, including EGF, transforming growth factor-alpha, and heparin-binding EGF. Previous studies have predominantly implicated subdomain III in ligand binding. To investigate a possible role for sequences in subdomain IV, we constructed several mutant EGFRs in which clusters of charged or aromatic amino acids were replaced with alanine. Analysis of stably transfected Chinese hamster ovary cells expressing mutant EGFRs confirmed that they were present on the cell surface at levels approaching that of the wild-type receptor. Although tyrosine phosphorylation of most mutants was markedly induced by EGF, a cluster mutation (mt25) containing four alanine substitutions in the span of residues 521-527 failed to respond. EGF-induced tyrosine phosphorylation of an alternative mutant (DeltaEN) with amino acids 518-589 deleted was also greatly diminished. Larger doses of EGF or heparin-binding EGF induced only weak tyrosine phosphorylation of mt25, whereas the response to transforming growth factor-alpha was undetectable. These results suggest that mt25 might be defective with respect to either ligand binding or receptor dimerization. Quantitative analyses showed that binding of (125)I-EGF to mt25 and DeltaEN was reduced to near background levels, whereas binding of EGF to other cluster mutants was reduced 60-70% compared with wild-type levels. Among the mutants, only mt25 and DeltaEN failed to form homodimers or to transphosphorylate HER2/Neu in response to EGF treatment. Collectively, our results are the first to provide direct evidence that discrete subdomain IV residues are required for normal binding of EGF family ligands. Significantly, they were obtained with the full-length receptor in vivo, rather than a soluble truncated receptor, which has been frequently used for structure/function studies of the EGFR extracellular region.
Populations; Exp1a; Exp2c; Exp4 from Long-tailed macaques (Macaca fascicularis) can use simple heuristics but fail at drawing statistical inferences from populations to samples
Creators: name: Placì, Sarah
name: Eckert, Johanna
name: Rakoczy, Hannes
name: Fischer, Julia
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Pictures of the different populations; Example of procedure; Example of Exp2c; Example with occluders
(1930) Joseph Prosser Sanderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bayesian Decision Tree for the Classification of the Mode of Motion in Single-Molecule Trajectories
Creators: name: Türkcan, Silvan
name: Masson, Jean-Baptiste
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Membrane proteins move in heterogeneous environments with spatially (sometimes temporally) varying friction and with biochemical interactions with various partners. It is important to reliably distinguish different modes of motion to improve our knowledge of the membrane architecture and to understand the nature of interactions between membrane proteins and their environments. Here, we present an analysis technique for single molecule tracking (SMT) trajectories that can determine the preferred model of motion that best matches observed trajectories. Information theory criteria, such as the Bayesian information criterion (BIC), the Akaike information criterion (AIC), and modified AIC (AICc), are used to select the preferred model. The considered group of models includes free Brownian motion, and confined motion in 2nd or 4th order potentials. We determine the best information criteria for classifying trajectories. We tested its limits through simulations matching large sets of experimental conditions and built a decision tree. This decision tree first uses the BIC to distinguish between free Brownian motion and confined motion. In a second step, it classifies the confining potential further using the AIC. We apply the method to experimental Clostridium Perfingens epsilon-toxin (CPepsilonT) receptor trajectories to show that these receptors are confined by a spring-like potential. An adaptation of this technique was applied on a sliding window in the temporal dimension along the trajectory. We applied this adaptation to experimental CPepsilonT trajectories that lose confinement due to disaggregation of confining domains. This new technique adds another dimension to the discussion of SMT data. The mode of motion of a receptor holds more biologically relevant information than the diffusion coefficient or domain size and may be a better tool to classify and compare different SMT experiments.
Supplemental Methods, Results, Tables and Figures from Bonobos voluntarily hand food to others but not toys or tools.
Creators: name: Krupenye, Christopher
name: Jingzhi Tan
name: Hare, Brian
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour

description: A key feature of human prosociality is direct transfers, the most active form of sharing in which donors voluntarily hand over resources in their possession. Direct transfers buffer hunter-gatherers against foraging shortfalls. The emergence and elaboration of this behaviour thus likely played a key role in human evolution by promoting cooperative interdependence and ensuring that humans' growing energetic needs (e.g. for increasing brain size) were more reliably met. According to the strong prosociality hypothesis, among great apes only humans exhibit sufficiently strong prosocial motivations to directly transfer food. The versatile prosociality hypothesis suggests instead that while other apes may make transfers in constrained settings, only humans share flexibly across food and non-food contexts. In controlled experiments, chimpanzees typically transfer objects but not food, supporting both hypotheses. In this paper, we show in two experiments that bonobos directly transfer food but not non-food items. These findings show that, in some contexts, bonobos exhibit a human-like motivation for direct food transfer. However, humans share across a far wider range of contexts, lending support to the versatile prosociality hypothesis. Our species' unusual prosocial flexibility is likely built on a prosocial foundation we share through common descent with the other apes.
Novel polyketide from Fusarium verticillioide G102 as NPC1L1 inhibitors
Creators: name: Zhang, Yuhan
name: Liu, Wenjing
name: Li, Gang
name: Wu, Changzheng
name: Yan, Jing
name: Feng, Dan
name: Yuan, Shuangzhi
name: Zhang, Renshuai
name: Lou, Hongxiang
name: Peng, Xiaoping
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: One novel polyketide, fusaritide A (1), was isolated from a marine fish-derived halotolerant fungal strain Fusarium verticillioide G102. The structure was determined through extensive spectroscopic analysis and high-resolution electrospray ionization mass spectrometry. Fusaritide A (1) with unprecedented structure reduced cholesterol uptake by inhibiting Niemann-Pick C1-Like 1 (NPC1L1).
Order of Assembly of Human DNA Repair Excision Nuclease
Creators: name: Sancar, Aziz
name: Wakasugi, Mitsuo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Human excision nuclease removes DNA damage by concerted dual incisions bracketing the lesion. The dual incisions are accomplished by sequential and partly overlapping actions of six repair factors, RPA, XPA, XPC, TFIIH, XPG, and XPF.ERCC1. Of these, RPA, XPA, and XPC have specific binding affinity for damaged DNA. To learn about the role of these three proteins in damage recognition and the order of assembly of the excision nuclease, we measured the binding affinities of XPA, RPA, and XPC to a DNA fragment containing a single (6-4) photoproduct and determined the rate of damage excision under a variety of reaction conditions. We found that XPC has the highest affinity to DNA and that RPA has the highest selectivity for damaged DNA. Under experimental conditions conducive to binding of either XPA + RPA or XPC to damaged DNA, the rate of damage removal was about 5-fold faster for reactions in which XPA + RPA was the first damage recognition factor presented to DNA compared with reactions in which XPC was the first protein that had the opportunity to bind to DNA. We conclude that RPA and XPA are the initial damage sensing factors of human excision nuclease.
(1932) Helen [Byrne]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplemental data_Urban Climate Change Adaptation and Mitigation: Are Action Plans Suitable?
Creators: name: Dacosta Aboagye, Prince
name: Sharifi, Ayyoob
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 370201
subject: Climate change processes
classificationCode: 330413
subject: Urban planning and health

description: The supplemental data is a list of appendix in the manuscript titled "Urban Climate Change Adaptation and Mitigation: Are Action Plans Suitable?".
Scintillation and Ionization Responses of Liquid Xenon to Low Energy Electronic and Nuclear Recoils at Drift Fields from 236 V/cm to 3.93 kV/cm
Creators: name: Lin, Qing
name: Fei, Jialing
name: Gao, Fei
name: Hu, Jie
name: Wei, Yuehuan
name: Xiao, Xiang
name: Wang, Hongwei
name: Ni, Kaixuan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present new measurements of the scintillation and ionization yields in liquid xenon for low energy electronic (about 3--7 keV$_{ee}$) and nuclear recoils (about 8--20 keV$_{nr}$) at different drift fields from 236 V/cm to 3.93 kV/cm, using a three-dimensional sensitive liquid xenon time projection chamber with high energy and position resolutions. Our measurement of signal responses to nuclear recoils agrees with predictions from the NEST model. However, our measured ionization (scintillation) yields for electronic recoils are consistently higher (lower) than those from the NEST model by about 5 e$^-$/keV$_{ee}$ (ph/keV$_{ee}$) at all scanned drift fields. New recombination parameters based on the Thomas-Imel box model are derived from our data. Given the lack of precise measurement of scintillation and ionization yields for low energy electronic recoils in liquid xenon previously, our new measurement provides so far the best available data covering low energy region at different drift fields for liquid xenon detectors relevant to dark matter searches.
description: 8 pages, 9 figures, submit to PRD
(1926) John W Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Poor Binding of a HER-2/neu Epitope (GP2) to HLA-A2.1 Is due to a Lack of Interactions with the Center of the Peptide
Creators: name: Kuhns, Jennifer J.
name: Collins, Edward J.
name: Batalia, Michael A.
name: Shuqin, Yan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Class I major histocompatibility complex (MHC) molecules bind short peptides derived from proteins synthesized within the cell. These complexes of peptide and class I MHC (pMHC) are transported from the endoplasmic reticulum to the cell surface. If a clonotypic T cell receptor expressed on a circulating T cell binds to the pMHC complex, the cell presenting the pMHC is killed. In this manner, some tumor cells expressing aberrant proteins are recognized and removed by the immune system. However, not all tumors are recognized efficiently. One reason hypothesized for poor T cell recognition of tumor-associated peptides is poor binding of those peptides to class I MHC molecules. Many peptides, derived from the proto-oncogene HER-2/neu have been shown to be recognized by cytotoxic T cells derived from HLA-A2(+) patients with breast cancer and other adenocarcinomas. Seven of these peptides were found to bind with intermediate to poor affinity. In particular, GP2 (HER-2/neu residues 654-662) binds very poorly even though it is predicted to bind well based upon the presence of the correct HLA-A2.1 peptide-binding motif. Altering the anchor residues to those most favored by HLA-A2.1 did not significantly improve binding affinity. The crystallographic structure shows that unlike other class I-peptide structures, the center of the peptide does not assume one specific conformation and does not make stabilizing contacts with the peptide-binding cleft.
Three new α-pyrone derivatives from the soil-derived fungus Penicillium herquei MA-370
Creators: name: Yang, Sui-Qun
name: Li, Xiao-Ming
name: Chen, Xiao-Dan
name: Li, Xin
name: Wang, Bin-Gui
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Three new α-pyrone derivatives, annularins L–N (1–3), were isolated from the EtOAc extract of Penicillium herquei MA-370, a fungus obtained from the rhizospheric soil of the mangrove plant Rhizophora mucronata. The planar structures of compounds 1–3 were determined based on comprehensive spectral interpretation of the NMR and MS data. The absolute configuration of 1 was determined by X-ray crystallographic data and that of 2 was assigned by TDDFT calculations of its ECD spectrum and cotton effects comparison with those of 1. The antimicrobial activity of compounds 1–3 was evaluated.
(1924) Mary E [Walker]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1925) Ebenezer Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Linear dichroism and the nature of charge order in underdoped cuprates
Creators: name: Norman, M. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Recent experiments have addressed the nature of the charge order seen in underdoped cuprates. Here, I show that x-ray absorption and linear dichroism are an excellent probe of such order. Ab-initio calculations reveal that a d-wave charge density wave order involving the oxygen ions is a much better description of the data than alternate models.
description: 3 pages, 3 figures
Cooling Requirements for the Vertical Shear Instability in Protoplanetary Disks
Creators: name: Lin, Min-Kai
name: Youdin, Andrew N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The vertical shear instability (VSI) offers a potential hydrodynamic mechanism for angular momentum transport in protoplanetary disks (PPDs). The VSI is driven by a weak vertical gradient in the disk's orbital motion, but must overcome vertical buoyancy, a strongly stabilizing influence in cold disks, where heating is dominated by external irradiation. Rapid radiative cooling reduces the effective buoyancy and allows the VSI to operate. We quantify the cooling timescale $t_c$ needed for efficient VSI growth, through a linear analysis of the VSI with cooling in vertically global, radially local disk models. We find the VSI is most vigorous for rapid cooling with $t_c
description: Accepted by ApJ; minor changes from previous version; a poster is available at http://lavinia.as.arizona.edu/~minkailin/docs/iaus314.pdf
How water contributes to pressure and cold denaturation of proteins
Creators: name: Bianco, Valentino
name: Franzese, Giancarlo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The mechanisms of cold- and pressure-denaturation of proteins are matter of debate and are commonly understood as due to water-mediated interactions. Here we study several cases of proteins, with or without a unique native state, with or without hydrophilic residues, by means of a coarse-grain protein model in explicit solvent. We show, using Monte Carlo simulations, that taking into account how water at the protein interface changes its hydrogen bond properties and its density fluctuations is enough to predict protein stability regions with elliptic shapes in the temperature-pressure plane, consistent with previous theories. Our results clearly identify the different mechanisms with which water participates to denaturation and open the perspective to develop advanced computational design tools for protein engineering.
description: submitted
Supplementary document for Non-mechanical three-dimensional LiDAR system based on flash and beam-scanning dually modulated photonic crystal lasers - 6242827.pdf
Creators: name: Zoysa, Menaka
name: Sakata, Ryoichi
name: Ishizaki, Kenji
name: Inoue, Takuya
name: Yoshida, Masahiro
name: Gelleta, John
name: Mineyama, Yoshiyuki
name: Akahori, Tomoyuki
name: Aoyama, Satoshi
name: Noda, Susumu
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: subject: 111302 Optical Technology
subject: FOS: Clinical medicine
subject: 90905 Photogrammetry and Remote Sensing
subject: FOS: Environmental engineering

description: Supplementary Information
Supplemental Methods, Results, Tables and Figures from Bonobos voluntarily hand food to others but not toys or tools
Creators: name: Krupenye, Christopher
name: Jingzhi Tan
name: Hare, Brian
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour

description: A key feature of human prosociality is direct transfers, the most active form of sharing in which donors voluntarily hand over resources in their possession. Direct transfers buffer hunter-gatherers against foraging shortfalls. The emergence and elaboration of this behaviour thus likely played a key role in human evolution, by promoting cooperative interdependence and ensuring that humans' growing energetic needs (e.g. for increasing brain size) were more reliably met. According to the strong prosociality hypothesis, among great apes only humans exhibit sufficiently strong prosocial motivations to directly transfer food. The versatile prosociality hypothesis suggests instead that while other apes may make transfers in constrained settings, only humans share flexibly across food and non-food contexts. In controlled experiments, chimpanzees typically transfer objects but not food, supporting both hypotheses. Here we show in two experiments that bonobos directly transfer food but not non-food items. These findings show that, in some contexts, bonobos exhibit a human-like motivation for direct food transfer. However, humans share across a far wider range of contexts, lending support to the versatile prosociality hypothesis. Our species' unusual prosocial flexibility is likely built on a prosocial foundation we share through common descent with the other apes.
Table S1 from Hydrodynamic performance of suction feeding is virtually unaffected by variation in the shape of the posterior region of the pharynx in fish.
Creators: name: Provini, Pauline
name: Wassenbergh, Sam Van
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Values of pressure, velocity, wall shear and forces for the four static, rotationally symmetric, unsteady flow models three different time steps of the simulation (t1 = 8ms, t2 = 20 ms, t3 = 200 ms) calculated on the sagittal plane of the model, the body surface, gill cover surface and head surface (See Figure 2 for the description of the different shapes of the models and the location of the surfaces).
Gypenoside biotransformation into ginsenoside F2 by endophytic Aspergillus niger from Gynostemma pentaphyllum
Creators: name: Zhang, Xuan
name: Xie, Yifan
name: Dai, Zhipeng
name: Liang, Yu
name: Zhu, Chunyu
name: Su, Chun
name: Song, Leshan
name: Wang, Kepei
name: Li, Jiang
name: Wei, Xiying
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Ginsenoside F2 is a protopanaxadiol saponin compound with various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Ginsenoside F2 can be found in ginseng, but in low quantities. Therefore, ginsenoside F2 production predominantly relies on the biotransformation of various ginsenosides, such as ginsenosides Rb1 and Rd. In this study, we reported the production of ginsenoside F2 by gypenoside biotransformation with Aspergillus niger JGL8, isolated from Gynostemma pentaphyllum. Ginsenoside F2 could be produced by two different biotransformation pathways, namely Gyp-V–Rd–F2 and Gyp-XVII–F2. The product exhibited antioxidant activity against free radicals (DPPH) with IC50 value of 29.54 µg/mL. Optimal biotransformation conditions were a pH of 5.0, temperature of 40 °C, and 2 mg/mL of substrate. Enzyme kinetic parameters revealed that the hydrolysis rate of Gyp-V, Rd, and Gyp-XVII was 0.625, 0.588, and 0.417 mM/h, respectively. In conclusion, we demonstrated that gypenoside is a substitutable substrate for ginsenoside F2 biotransformation.
Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity
Creators: name: Bi, De-Wen
name: Feng, Jian-
name: Pang, Wen-Hui
name: Yang, Peng-Yun
name: Xu, Yao-Jun
name: Zeb, Muhammad Aurang
name: Wang, Meng-Ru
name: Zhang, Xing-Jie
name: Li, Xiao-Li
name: Zhang, Rui-Han
name: Wang, Wei-Guang
name: Xiao, Wei-Lie
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Three new lanostane triterpenoids (1-3) along with two new amides fatty compounds (4-5) were isolated from the ethyl acetate extract of a culture of the endophytic fungus Alternaria sp. gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds 1-12 were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound 1 was 54.45%, indicating that compound 1 had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome.
Theoretical Study on Anisotropic Magnetoresistance Effects of Arbitrary Directions of Current and Magnetization for Ferromagnets: Application to Transverse Anisotropic Magnetoresistance Effect
Creators: name: Kokado, Satoshi
name: Tsunoda, Masakiyo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We develop a theory of the anisotropic magnetoresistance (AMR) effects of arbitrary directions of current and magnetization for ferromagnets. Here, we use the electron scattering theory with the $s$--$s$ and $s$--$d$ scattering processes, where $s$ is the conduction electron state and $d$ is the localized d states. The resistivity due to electron scattering is expressed by the probability density of the d states of the current direction. The d states are numerically obtained by applying the exact diagonalization method to the Hamiltonian of the d states with the exchange field, crystal field, and spin--orbit interaction. Using the theory, we investigate the transverse AMR (TAMR) effect for strong ferromagnets with a crystal field of cubic or tetragonal symmetry. The cubic systems exhibit the fourfold symmetric TAMR effect, whereas the tetragonal systems show the twofold and fourfold symmetric TAMR effect. On the basis of the above results, we also comment on the experimental results of the TAMR effect for Fe$_4$N.
description: 31 pages, 5 figures, J. Phys. Soc. Jpn. (2022), accepted
(1927) Alfred E Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Table S2 from Hydrodynamic performance of suction feeding is virtually unaffected by variation in the shape of the posterior region of the pharynx in fish.
Creators: name: Provini, Pauline
name: Wassenbergh, Sam Van
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Comparison of the maximum values of pressure and velocity calculated on the midsagittal and a frontal plane of the two static, 3D-scan based, steady flow models as well as maximum values of pressure and of wall shear, and value of axial force on the fish surface.