cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Recurrent Preterm Birth in Utah
Creators: name: Simonsen, Sara Marie Ellis
Publisher: name: University of Utah
Year: 2014

description: In multiparous women, history of preterm birth is a risk factor for recurrence. We examined patterns of recurrent preterm birth by clinical presentation and additional risk factors for recurrence among 76,657 women who had their first three singleton live births in Utah, 1989- 2007. We also evaluated the association between gestational weight gain and preterm birth using a bidirectional case-crossover study to control for genetics and other time-invariant characteristics. Unadjusted and multivariable-adjusted logistic regression, multinomial regression, and conditional logistic regression were used to calculate odds ratios (OR). In our study women were likely to experience recurrent preterm birth of the same clinical subtype; however, recurrence of other clinical subtypes was also common. The highest odds of recurrence were in women with two prior preterm births of the same subtype. Additional risk factors for recurrence included a short interpregnancy interval, the presence of a preexisting maternal medical condition, history of a birth at 28-32 weeks gestation, and the presence of a fetal anomaly on the birth record for the current live birth. Risk factors varied depending upon the clinical subtype of the most recent preterm birth. Finally, we found that women who gained more weight than recommended during pregnancy were at risk for indicated preterm birth while those who gained less than recommended were at risk for spontaneous preterm birth.
Additional file 1 of Morphological characterization and habitat suitability modeling of the goat population of Benin under climate change scenarios
Creators: name: Whannou, Habib Rainier Vihotogbe
name: Afatondji, Cossi Ulriche
name: Linsoussi, Côme Agossa
name: Favi, Gnimansou Abraham
name: Nguyen, Thanh Thi
name: Houinato, Marcel Romuald Benjamin
name: Dossa, Luc Hippolyte
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 1: Fig. S1. Djallonké buck. Fig. S2. Djallonké doe. Fig. S3. Sahelian bucks. Fig. S4. Sahelian does. Fig. S5. Crossbreed buck. Fig. S6. Crossbreed doe.
Gender and health in abusive relationships
Creators: name: Sillito, Carrie Ann LeFevre
Publisher: name: University of Utah
Year: 2012
Subjects: Domestic violence
Gender
Health
Intimate partner abuse
Intimate partner violence

description: Researchers have long recognized intimate partner abuse as a social problem, but only recently has it been recognized as a public health problem. However, research to this point has failed to examine whether the health effects of intimate partner violence vary by  gender. This dissertation uses data from the National Survey of Families and Households to examine the effects of intimate partner abuse on physical health, depression, fear, stress, social connectedness, and access to resources in intimate partner relationships. All  models are stratified by gender in order to examine gender differences in health outcomes. Results indicate that there are gender differences, with a female disadvantage on many outcomes. Implications include inclusion of violence outcomes in future research of IPA, and recognition that "symmetry" definitions should include more than simple rates and ratios of violence reporting. Furthermore, this research indicates a need  to expand the study of gender in low-level violence to assess other differences that were not addressed in this study.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.12.1967, erstellt von Latif Topaktas an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Cytotoxic activity and triterpenes content of nine Mexican species of Bursera
Creators: name: Sánchez-Monroy, Ma. Beatriz
name: León-Rivera, Ismael
name: Llanos-Romero, R. Enrique
name: García-Bores, Ana María
name: Guevara-Fefer, Patricia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The genus Bursera (Burseraceae) is considered an interesting source of antitumour compounds. This study aimed to evaluate the cytotoxic activity of the dichloromethane-soluble extracts from the bark of nine Mexican Bursera species. The chemical components of the extracts were determined by NMR and mass spectroscopy, whereas its cytotoxicity was tested using the sulphorhodamine (SRB) method on seven cell lines. Triterpenes and fatty acids were the most abundant components found in the extracts. A quantification by HPTLC – densitometry, showed that the species B. copallifera had the highest content of amyrins (287 µg/mg extract) followed by B. submoniliformis (159.5 µg/mg) and B. bicolor (156.5 µg/mg). Regarding cytotoxicicity, the species B. bicolor caused the highest growth inhibition (>90%) in colon (HCT-15) and lung (SK-LU1) lines; while B. fagaroides, B. grandifolia, B. morelensis, B. bicolor and B. linanoe were active in the SK-LU1cell line.
Sonnenfleckenzeichnung Nr. 22643.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.10.1967, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A prospective comparison of the incidence of increased serum enzymes in patients receiving either beef lung or pork intestinal mucosal heparin
Creators: name: Burnakis, Thomas George
Publisher: name: University of Utah
Year: 2013

description: Hypertransaminasemia, increased serum transaminases, is a recognized side-effect of heparin. The potential clinical significance and mechanism of this side-effect remains to be determined. Hypertransaminasemia associated with heparin has not been reported to produce clinical illness; however, the determination of transaminase levels is an established diagnostic aid for pulmonary embolism, hepatic damage  and myocardial infarction which could be misdiagnosed in the presence of heparin administration. Likewise, transaminase levels can be valuable prognostic and monitoring aids in certain rheumatic diseases, which may be lost in the patients receiving heparin. In their original observation of this phenomenon, Sonnenblick, et al noted a transient rise in patients' serum transaminase values during a course of full-dose heparin therapy. This prospective study demonstrated that 10 of 14 patients had elevated serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels during a regimen of therapeutic heparinization, and return to normal values with cessation of therapy. Maximum transaminase elevations were 3 to 5 times normal values and were not associated with subjective symptoms. Levels of SGPT were higher than those of SGOT, suggesting a hepatic origin for the hypertransaminasemia. the objectives of this study were threefold: 1.) To determine the incidence of elevated serum enzyme (SGPT, SGOT and LDH) levels attributable to the administration of heparin to adult medical and surgical patientsd; 2.) To characterize the observed onset, duration and course of the heparin induced rise in serum enzymes; and 3.) To delineate differences between pork instestinal and beef lung mucosal heparin in the frequency or extent of the induced rise in serum enzymes.
Integrating Technologies, Methodologies, and Databases into a Comprehensive Terminology Management Environment to Support Interoperability Among Clinical Information Systems
Creators: name: Shakib, Shaun Cameron
Publisher: name: University of Utah
Year: 2014

description: Controlled clinical terminologies are essential to realizing the benefits of electronic health record systems. However, implementing consistent and sustainable use of terminology has proven to be both intellectually and practically challenging. First, this project derives a conceptual understanding of the scope and intricacies of the challenge by applying informatics principles, practical experience, and real-world requirements. Equipped with this understanding, various approaches are explored and from this analysis a unique solution is defined. Finally, a working environment that meets the requirements for creating, maintaining, and distributing terminologies was created and evaluated.
Sonnenfleckenzeichnung Nr. 22645.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.10.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.11.1967, erstellt von Gisèle Evrard-Kesteloot, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl
Creators: name: Akosung, Emmanuel
name: Kenmogne, Sidonie Beactrice
name: Songue, Jules Lobe
name: Ekon, Jean Pierre Longue
name: Lateef, Mehreen
name: Happi, Emmanuel Ngeufa
name: Langat, Moses Kiprotich
name: Tabekoueng, Georges Bellier
name: Toze, Flavien Aristide Alfred
name: Stammler, Hans-Georg
name: Lenta, Bruno Ndjakou
name: Wansi, Jean Duplex
name: Sewald, Norbert
name: Ali, Muhammad Shaiq
name: Waffo, Alain François Kamdem
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3β,23-dihydroxy D:A-friedooleanan-28-oic acid (1) and one new prenylated xanthone, lacexanthone or 4,7-dihydroxy-2,3,3,9,9-pentamethyl-2,2-dihydrofurano[2,3-a]pyrano[2,3-i]xanthen-13(9H)-one (2) alongside twenty-four known compounds. Compounds 1-11 are reported here for the first time from the genus Manilkara. The structures of all compounds were determined by spectroscopic analyses and X-ray crystallography. The methanolic extracts of twigs and leaves showed anti-oxidant activity of 93.2 and 91.1%, respectively, at 100 µg/mL when measured by DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate), while the twig extract displayed 86.3% at 100 µg/mL against the urease inhibition assay. Some isolated compounds (1-4, 15 and 20) showed significant to moderate anti-oxidant activity and urease inhibition assay. It is estimated that significantly active anti-oxidants and urease inhibitors metabolized by the plant may find future application in food industry.
Sonnenfleckenzeichnung Nr. 22675.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.12.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 2 of Morphological characterization and habitat suitability modeling of the goat population of Benin under climate change scenarios
Creators: name: Whannou, Habib Rainier Vihotogbe
name: Afatondji, Cossi Ulriche
name: Linsoussi, Côme Agossa
name: Favi, Gnimansou Abraham
name: Nguyen, Thanh Thi
name: Houinato, Marcel Romuald Benjamin
name: Dossa, Luc Hippolyte
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 2: Table S1. Characteristics of the ten phytogeographic zones of Benin. Table S2. Description of linear body measurements (in centimeters) and qualitative traits taken on 2114 adult female goats in Benin. Table S3. Morphological indices calculated from linear body measurements taken on 2114 adult female goats in Benin. Table S4. Goat types, occurrence numbers, and most discriminating variables. Table S5. Environmental variables used and their description. Table S6. Incidence of vegetation zone, doe’s parity number, and presence or absence of supernumerary teats on birth type. Table S7. Stepwise selection summary. Table S8. Total canonical coefficients for the canonical function, the adjusted canonical correlation, the eigenvalue, and the percentage total variance accounted for. Table S9. Mahalanobis distances between goat subpopulations identified by vegetation zones (n=2114). Table S10. Mahalanobis distances between goat subpopulations identified by phytogeographic zones (n=2114). Table S11. Dynamic of distribution of suitable habitat for the distribution of goat subpopulations GCZ, GSZ, and SZ under two RCPs scenarios in Benin Table S12. Percentage change of the suitability levels (low, moderate, suitable, high) for the distribution of GCZ, GSZ and SZ goat subpopulations. Table S13. Morphometric characteristics of the goat types of Benin.
title: COVID - 19
Creators: name: Home Modification Information Clearinghouse
Publisher: name: Home Modification Information Clearinghouse
Year: 2020

description: This factsheet aims to give information on how health professionals and service providers working with older people and people with disability can protect themselves and their clients during the COVID-19 outbreak.
description: Industry Factsheet: COVID-19 Information for service providers conducting home visits Protective measures against COVID-19 for service providers Telehealth services during the COVID-19 outbreak Unfinished building works due to the COVID-19 outbreak Other useful links for the safety and hygiene of professionals and consumers Where can I find more information?
Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam
Creators: name: Le Canh Viet Cuong
name: Le Tuan Anh
name: Dat, Ton That Huu
name: Anh, Tran Thi Phuong
name: Le Quynh Lien
name: Kim, Young Ho
name: Le Tuan Anh, Hoang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: A new ursane-type triterpene, 3β,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2–9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2–5 were found for the first time from the genus Ophiorrhiza, while compounds 6–9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (1H-NMR, 13C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.
Sonnenfleckenzeichnung Nr. 22607.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.09.1967, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A descriptive analysis of the immunosuppressive regimens of the utah cardiac transplant program
Creators: name: McCollam, Patrick L.
Publisher: name: University of Utah
Year: 2013

description: Following animal experiments supporting the feasibility of heart transplantation, the first human heart transplant was performed in December, 1967, in Capetown, South Africa. the first successful operation in the United States was in May, 1968. Although approximately 100 transplants were performed worldwide in 1968, there were few long -term survivors. Between 1969 and the mid 1970s, only a small number of transplants were performed due to the limited ability to combat rejection and infection; the two main causes of mortallity in cardiac transplantation. By 1980, only 400 heart transplants had been done worldwide with over half of these performed at Stanford. In 1968, Stanford's one-year patient survival rate was only 22%, but by 1979 it had increased to 67%, a success rate that exceeded the expected survival of patients with end-stage heart failure 1,2. A great deal of this increased success was directly attributable to betters agents for immunosupression such as antithymocyte globulin (ATG) which added to the Stanford protocol in 1972. Also, the use of myocardial biopsy to detect early rejection allowed appropriate therapy to be initiated before overt clinical signs of rejection were seen. Prior to 1980, most centers used some combination of azathioprine, corticosteroids and ATG for immunosuppression. When Cyclosporine A (CyA) was introduced in 1980, it was perceived as a significant advancement in immunosuppressive therapy since it was thought to be both more effective and less toxic than other agents available at that time. The development of cyclosporine created renewed interest in cardiac transplantation and the field grew rapidly. According to recent figures, the number of U.S. centers increased to 74 by 1985 and more cardiac transplants were performed in the U.S. during 1980-82 than had been done in all previous years. The Utah Cardiac Transplant Program (UCTP) was started in March of 1985. As of September 1, 1986, 50 heart transplants had been performed. Although some episodes of rejection have occurred, the patient survival rate is currently 97% at one year - the best in the country. The immunosuppressive regimen has changed during this period of time with the addition of randomized trials using vincristine and Orthoclone OK13 combine with the standard regimen of cyclosporine, ATG, corticosteroids and azathioprine. In anticipation that other institutions will desire to duplicate one of these regimens, a complete descriptive analysis of the therapeutic and toxic effects of these immunosuppressive regimens is warranted.
Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line
Creators: name: Elhassan, Safa Abdelgadir Mohamed
name: Candasamy, Mayuren
name: Ching, Tan Swee
name: Heng, Yap Kah
name: Bhattamisra, Subrat Kumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology

description: Currently, type 2 diabetes mellitus (T2D) has emerged as global burden disease. Herbal drugs with antidiabetic activities are attracting the attention. Madecassoside and catalpol are herbal compounds having strong antioxidant and glucose lowering activity. Madecassoside and catalpol were investigated for their effect on insulin sensitivity using pancreatic INS-1E cells. Cytotoxicity of these compounds was evaluated by MTT assay. Glucose-stimulated insulin secretion (GSIS) and expression of insulin signalling proteins were studied in presence of madecassoside and catalpol. Results revealed that madecassoside and catalpol enhanced the GSIS without cytotoxic effect. Madecassoside (30 µM) and catalpol (40 µM) increased the insulin secretion in response to high glucose (16.7 mM) stimulation. Subsequently, madecassoside and catalpol showed elevated expression of p-IRS-1, Akt, and p-Akt proteins. Madecassoside and catalpol after 24 h of incubation in pancreatic INS-1E cells with high glucose concentration (30 mM) ameliorated the insulin secretion.
ANALYSIS OF THEORETICAL APPROACHES TO THE ROLE AND ECONOMIC CONTENT OF INVESTMENTS IN THE INNOVATIVE DEVELOPMENT OF TOURISM
Creators: name: Mamayunusov, Temurbek
Publisher: name: Zenodo
Year: 2025

description: Solving theoretical and practical problems of investments is of great importance not only for the development of material production, but also for the development of the intangible sector, including tourism. Because the tourism sector is an important factor in the effective use of the rich historical and cultural potential of the country's national economy, its individual regions, a multiplier that multiplies their positive effect several times. The author analyzed theoretical approaches to the role and economic content of investments in the innovative development of tourism in the article.
Transcription Factor OCT1 Regulates Adult and Malignant Stem Cells
Creators: name: Maddox, Jessica
Publisher: name: University of Utah
Year: 2014

description: For many years the Oct1 transcription factor was though to behave as a static regulator of housekeeping genes and was constitutively bound to the octamer binding sites of its targets. However, recently there has been a significant amount of evidence from our lab and others that has shifted the paradigm and caused the scientific community to change the way they think about this transcription factor. Oct4, a close family member to Oct1, is well known to be a regulator of pluripotency in embryonic stem cells. Oct4 and Oct1 have similar binding site specificity, similar gene targets and they are both observed to display stem cell properties. However, the role of Oct1 in stem cell identity was unknown. I have established that Oct1 is dynamically regulated and critical for somatic stem cell identity and stem cells in cancer. I have determined that high Oct1 protein levels correlate with stem cell markers in multiple epithelial tissues, both normal and malignant. Using multiple stem cell matrices, I determined that loss of Oct1 results in a decrease in the stem cell population. Reciprocally, a gain in Oct1 results in an increase in the stem cell population. Also, I found that Oct1 transcriptionally regulates multiple functional stem cell markers, including Aldh1a and Abcg2. Previous studies identified multiple posttranslational modifications to Oct1 protein in HeLa cells, including phosphorylation, glycosylation, and ubiquitination. Here I established that K9 and K403 ubiquitin sites of Oct1 are important for degradation. I determined that Oct1 protein levels are significantly reduced by ~80% in the presence of wildtype BRCA1. However, Oct1 mRNA levels are only reduced less than 2 fold with BRCA1. By mutating the ubiquitin sites from Lysine to Arginine (K9/403R) and transducing stable expression of these mutants, I found that Oct1 protein levels greatly increase in the presence of BRCA1. This indicates that mutating the ubiquitin sites protects Oct1 from BRCA1 dependent degradation, thus supporting my hypothesis that Oct1 is a BRCA1 E3 ubiquitin ligase target.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.09.1967, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Development of a fast response building resolving urban energy model
Creators: name: Allen, Chad
Publisher: name: University of Utah
Year: 2012
Subjects: CFD
Convection
GPU
Heat transfer
Radiation
Urban
QUIC
Urban wind
Particle dispersion

description: QUIC (Quick Urban and Industrial Complex) is a fast running urban wind and particle dispersion modeling system. This empirically based building-resolving model  has been developed to rapidly compute the wind flow through urban environments and predict contaminate dispersion. The information provided by QUIC can be used by planners to predict an optimal location to place a new structure within an existing urban layout based upon the effectiveness of the natural wind flow to remove pollutants from within a city. Furthermore, a new structure's optimal location can also be based upon  minimizing the required heating or cooling throughout the year. To analyze the energy transfer within an urban environment, heat transfer modes such as convection,  radiation, and latent heat transfer must be considered. The work presented here describes the development of an energy model designed to calculate the total energy  transfer to and from structures within an urban center by analyzing thermal advection, diffusion, and radiation. To meet the criteria of the QUIC program and rapidly model the energy transfer within the environment, the energy model is being developed using a Single Input Multiple Data (SIMD) parallel computational structure using CUDA. CUDA is a parallel programming application based on C which uses an NVIDIA graphics card  to perform multiple calculations simultaneously and enhance computational performance.
Preparation and properties of leucine aminopeptidase
Creators: name: Spackman, Darrel H.
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism

description: Swine kidney has been used as a source for leucine aminopeptidase. A purification procedure has been worked out to produce highly purified preparations of this enzyme in good yield. The 8 steps involve conversion to an acetone powder, fractional precipitation with inorganic salts and with organic solvents, heating, aging, and finally separation by zone electrophoresis. Preparations have been obtained with a C1 = 88 for L-leucinamide representing a 1600 fold purification over the level found in crude kidney extracts.  Such preparations appear to be homogeneous in the ultracentrifuge, and upon paper electrophoresis and very nearly homogeneous in the Tiselius electrophoresis. A tentative molecular weight of 300,000 has been determined for this enzyme. The aminopeptidase has been further studied by determining its absorption spectrum in the ultraviolet and by determining its amino acid content. Over 97 per cent of the protein has been accounted for as the naturally occurring amino acids and this evidence together with the previous evidence indicate that leucine aminopeptidase is a large, simple protein and there is no evidence for any prosthetic group, The activation and stability of this enzyme in the presence of its two specific metal activators, Mn++ and Mg++, have been studied in some detail and a comparison of the effects of the two metal activators made. Activation times for both metals have decreased from several hours to a few minutes with purification and in the highly purified state, rapid inactivation occurs upon removal of the metal components. A substrate-activation effect has been noted at certain metal concentrations and the implications of this have been discussed.  The metal dissociation constants for both metals have been determined and are found to be 1.2 X 10(4) molar-1 for Mg++ and 3.3 1 10(4) molar-1 for Mn++. A relationship between the enzyme and each of the metals has been found which suggests that one metal ion combines for each active site of enzyme. The variation of activity with pH has been studied for 2 substrates and with both metals and the pH optimum for the enzyme appears to be 9.1 to 9.3. Several new amino acid amides have been synthesized making available nearly all of the naturally occurring amino acids in amide form. A total of more than 50 substrates have been subjected to the action of the highly purified leucine aminopeptidase and it has been found that a general activity is shown. L-alanyl-L-leucinamide is hydrolyzed with a C0 of 26,000 corresponding to a turnover number of 208,000 moles hydrolyzed per minute per 100,000 gm. of enzyme.  Evidence is reviewed for the elimination of the presence of other enzymes and various aspects of specificity are discussed including a comparison with other well characterized proteolytic enzymes.
Effect of animated self-avatar in virtual environments
Creators: name: Raj, Mukund
Publisher: name: University of Utah
Year: 2013
Subjects: Avatars
Virtual environment

description: Animated avatars are becoming increasingly prevalent in three-dimensional virtual environments due to modern motion tracking hardware and their falling cost. As this opens up new possibilities and ways of interaction within such virtual worlds, an important question that arises is how does the presence of an avatar alter the perception and performance of an action in a virtual environment when a user interacts with an object in the virtual environment through their avatar. This research attempts to answer this question by studying the effects of presence of an animated self-avatar in an object manipulation task in a virtual environment. Two experiments were conducted as part of this research. In Experiment 1, the feasibility of an interaction system involving animated self-avatars to manipulate objects in a virtual environment was examined. It was observed that the presence of self-avatars had an affect on the performance of a subset of subjects. Male subjects with gaming experience performed similarly across both visual feedback conditions while female subjects who also had low gaming experience performed better in the condition with avatar feedback than in the condition without avatar feedback. In Experiment 2, we further analyzed the effect of presence of self-avatar visual feedback by looking at the effect of visual immersion in the virtual environment, task difficulty, and individual difference factors such as spatial ability and gaming experience. It was observed that difficult trials were completed significantly faster by subjects in the avatar feedback condition while in the case of the easy trials, there was no significant difference between performance of subjects in the avatar and sphere feedback conditions. No significant interaction was observed between visual feedback condition and either immersiveness or individual difference factors.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität nach einer Projektion vom 13.09.1967, erstellt von Max Waldmeier am Astrophysikalischen Observatorium Tschuggen in Arosa
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung am Astrophysikalischen Observatorium Tschuggen in Arosa. Instrument: Visuelles Objektiv an der Coelostatenanlage (15 cm Öffnung und 224 cm Brennweite, projiziertes Sonnenbild D = 25 cm). - Instrumentennachweis gemäss Tätigkeitsber. gedr. 1950 für das vorhergehende Jahr, S. 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
Accent classification: learning a distrance metric over phonetic strings
Creators: name: Machanavajhala, Swetha
Publisher: name: University of Utah
Year: 2014
Subjects: Accent classification
Distance metric learning
Kernels
Machine learning
Speech recognition
Swetha Machanavajhala

description: Presently, speech recognition is gaining worldwide popularity in applications like Google Voice, speech-to-text reporter (speech-to-text transcription, video captioning, real-time transcriptions), hands-free computing, and video games. Research has been done for several years and many speech recognizers have been built. However, most of the speech recognizers fail to recognize the speech accurately. Consider the well-known application of Google Voice, which aids in users search of the web using voice. Though Google Voice does a good job in transcribing the spoken words, it does not accurately recognize the words spoken with different accents. With the fact that several accents are evolving around the world, it is essential to train the speech recognizer to recognize accented speech. Accent classification is defined as the problem of classifying the  accents in a given language. This thesis explores  various methods to identify the accents. We introduce a new concept of clustering windows of a speech signal  and learn a distance metric using specific distance  measure over phonetic strings to classify the accents. A language structure is incorporated to learn this distance metric. We also show how kernel approximation algorithms help in learning a distance metric.
Sonnenfleckenzeichnung Nr. 22668.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.11.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 22585.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.08.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The effects of a smoking education risk reduction program on selected student impact measures
Creators: name: Nelson, Gary D.
Publisher: name: University of Utah
Year: 2013

description: The problem of the study was to determine the extent to which an experimental smoking education risk reduction curriculum affects resistance to persuasion skills, selected decsion making skills, knowledge of the health consequences of smoking, and tobacco use including cigarette smoking among sixth grade students.  Following inservice training with the experimental curriculum, 14 Salt Lake city School district teachers and 316 subjects were randomly assigned to the experimental and control group conditions. Seven teachers and 180 subjects were assigned to the experimental group and seven teachers with 136 subjects were assigned to the control group. An additional 9 teachers ans 218 subjects were selected as a nonequivalent control group. A pretest posttest control group design with the additional of a nonequivalent control group was used in the study. Experimental group teachers implemented the educational program within their sixth grade classrooms during the 1981/1982 academic school year. The experimental, control, and non equivalent control group subjects' tobacco use including cigarette smoking, knowledge of the health consequences of smoking and selected decision making and resistance to persuasion skills were pretested prior to the implementation of the curriculum and/or posttested at the completion of the 15 week instruction period. All data were analyzed using the Mantel-Haenszel , McNemer, and Pearson Chi-square statistics and analysis of covariance. Analysis of the results revealed no significant group or gender differences on tobacco use including smoking behavior. Significant group differences were found on measures of knowledge, and decision making and resistance to persuasion skills. results of this study were intrepreted to mean that the experimental curriculum effectively de-emphasized the long-range health consequences of smoking in favor of the immediate health effects. The subjects' application of relevant knowledge in the decision making process as well as the ability to identify and recommend selected resistance to persuasion skills provide further evidence of the beneficial effects of the curriculum.
Sonnenfleckenzeichnung Nr. 22603.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.09.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Chemical constituent and radical scavenging antioxidant activity of Anthemis kotschyana Boiss
Creators: name: Bursal, Ercan
name: Aras, Abdulmelik
name: Kılıç, Ömer
name: Buldurun, Kenan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Phenolic content and antioxidant activity of Anthemis kotschyana Boiss. var. discoidea (A. kotschyana) were reported in this study. The ethanol extract of Anthemis kotschyana (EEA) and the water extract of Anthemis kotschyana (WEA) were prepared and used for biochemical analyses. Radical scavenging antioxidant capacities of EEA and WEA were evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging method. Another goal of the study was to evaluate the phenolic compositions of A. kotschyana by liquid chromatography and tandem mass spectrometry (LC-MS/MS). Rhamnetin (5.484 ± 0.020 ppm; µg/g extract) and quinic acid (2.251 ± 0.012 ppm; µg/g extract) were identified as major two compounds in the plant sample. This study will be a scientific base for further studies about A. kotschyana for plant biochemistry and plant-based pharmacological industry.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.12.1967, erstellt von Peter Rovithis, Eugenides Planetarium in Athen.
Zusätzlich ist vermerkt: massgebendes Blatt
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm). Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt
Sonnenfleckenzeichnung Nr. 22629.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.10.1967, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.09.1967, erstellt als zweite Tagesaufnahme um 14 h 35 von Annie Hovaere, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung Nr. 22667.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.11.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures
Creators: name: Sharma, Vandana
name: Varshney, Rajeev
name: Sethy, Niroj Kumar
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 contains IPA based integrated analysis of temporal high altitude proteomics data and overlapping canonical pathways associated with common proteins and gene selection signaures of high altitude adaptation. 1. Figure S1 to S4 reperesent the top canonical pathways associated with high altitude proteomics data in temporal human plasma, saliva and serum samples using IPA. 2. Figure S5 represents the top 15 canonical pathways associated with the overlapping protein markers and gene selection signatures for high altitude adaptation. 3. Table S2 and S3 represents the identified gene selection signatures reported to be imparting the positive selection in HA environment and protein markers differentially regulated at high altitude.