cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 5: Supplementary Table 4. Effects (95% CI) in Single and Double pollutant models.
PDF EPUB Download The Sluts by Dennis Cooper Full Book
Creators: name: Henry
Publisher: name: Zenodo
Year: 2024

description: The Sluts by Dennis Cooper

 

 

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The Sluts

Dennis Cooper

Page: 262

Format: pdf, ePub, mobi, fb2

ISBN: 9780786716746

Publisher: Da Capo Press

 

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Overview

Set largely on the pages of a website where gay male escorts are reviewed by their clients, and told through the postings, emails, and conversations of several dozen unreliable narrators, The Sluts chronicles the evolution of one young escort's date with a satisfied client into a metafiction of pornography, lies, half-truths, and myth. Explicit, shocking, comical, and displaying the author's signature flair for blending structural complexity with direct, stylish, accessible language, The Sluts is Cooper's most transgressive novel since Frisk, and one of his most innovative works of fiction to date.
Widespread Galactic CF+ absorption: detection toward W49 with the Plateau de Bure Interferometer
Creators: name: Liszt, H. S.
name: Guzman, V. V.
name: Pety, J.
name: Gerin, M.
name: Neufeld, D. A.
name: Gratier, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: To study the usefulness of \CFP\ as a tracer of the regions where C\p\ and \HH\ coexist in the interstellar medium. We used the Plateau de Bure Interferometer to synthesize \CFP\ J=1-0 absorption at 102.6 GHz toward the core of the distant HII region W49N at l = 43.2\degr, b=0.0\degr, and we modeled the fluorine chemistry in diffuse/translucent molecular gas. We detected \CFP\ absorption over a broad range of velocity showing that \CFP\ is widespread in the \HH-bearing Galactic disk gas. Originally detected in dense gas in the Orion Bar and Horsehead PDR, \CFP\ was subsequently detected in absorption from diffuse and translucent clouds seen toward \bll\ and 3C111. Here we showed that \CFP\ is distributed throughout the diffuse and translucent molecular disk gas with N(\CFP)/N(\HH) $= 1.5-2.0\times10^{-10}$, increasing to N(\CFP)/N(\HH) $= 3.5\times10^{-10}$ in one cloud at 39 \kms\ having higher N(\HH) $\approx 3\times10^{21}\pcc$. Models of the fluorine chemistry reproduce the observed column densities and relative abundance of HF, from which \CFP\ forms, but generally overpredict the the column density of \CFP\ by factors of 1.4-4. We show that a free space photodissociation rate $Γ\ga 10^{-9}\ps$, comparable to that of CH, might account for much of the discrepancy but a recent calculation finds a value about ten times smaller. In the heavily blended and kinematically complex spectra seen toward W49, \CFP\ absorption primarily traces the peaks of the \HH\ distribution.
description: A&A in press
The Role of Actin in Spindle Orientation Changes during the Saccharomyces cerevisiae Cell Cycle
Creators: name: Lew, Daniel J.
name: Theesfeld, Chandra L.
name: Irazoqui, Javier E.
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: In the budding yeast Saccharomyces cerevisiae, the mitotic spindle must align along the mother-bud axis to accurately partition the sister chromatids into daughter cells. Previous studies showed that spindle orientation required both astral microtubules and the actin cytoskeleton. We now report that maintenance of correct spindle orientation does not depend on F-actin during G2/M phase of the cell cycle. Depolymerization of F-actin using Latrunculin-A did not perturb spindle orientation after this stage. Even an early step in spindle orientation, the migration of the spindle pole body (SPB), became actin-independent if it was delayed until late in the cell cycle.Early in the cell cycle, both SPB migration and spindle orientation were very sensitive to perturbation of F-actin. Selective disruption of actin cables using a conditional tropomyosin double-mutant also led to de- fects in spindle orientation, even though cortical actin patches were still polarized. This suggests that actin cables are important for either guiding astral microtubules into the bud or anchoring them in the bud. In addition, F-actin was required early in the cell cycle for the development of the actin-independent spindle orientation capability later in the cell cycle. Finally, neither SPB migration nor the switch from actin-dependent to actin-independent spindle behavior required B-type cyclins.
Effective Preconditioners for Mixed-Dimensional Scalar Elliptic Problems
Creators: name: Hu, Xiaozhe
name: Keilegavlen, Eirik
name: Nordbotten, Jan M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Discretization of flow in fractured porous media commonly lead to large systems of linear equations that require dedicated solvers. In this work, we develop an efficient linear solver and its practical implementation for mixed-dimensional scalar elliptic problems. We design an effective preconditioner based on approximate block factorization and algebraic multigrid techniques. Numerical results on benchmarks with complex fracture structures demonstrate the effectiveness of the proposed linear solver and its robustness with respect to different physical and discretization parameters.
Yes-Associated Protein 65 Localizes P62 c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50
Creators: name: Mohler, Peter J.
name: Milgram, Sharon L.
name: Sudol, Marius
name: Stutts, M. Jackson
name: Boucher, Richard C.
name: Kreda, Silvia M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: We recently showed that the COOH terminus of the cystic fibrosis transmembrane conductance regulator associates with the submembranous scaffolding protein EBP50 (ERM-binding phosphoprotein 50 kD; also called Na+/H+ exchanger regulatory factor). Since EBP50 associates with ezrin, this interaction links the cystic fibrosis transmembrane conductance regulator (CFTR) to the cortical actin cytoskeleton. EBP50 has two PDZ domains, and CFTR binds with high affinity to the first PDZ domain. Here, we report that Yes-associated protein 65 (YAP65) binds with high affinity to the second EBP50 PDZ domain. YAP65 is concentrated at the apical membrane in airway epithelia and interacts with EBP50 in cells. The COOH terminus of YAP65 is necessary and sufficient to mediate association with EBP50. The EBP50–YAP65 interaction is involved in the compartmentalization of YAP65 at the apical membrane since mutant YAP65 proteins lacking the EBP50 interaction motif are mislocalized when expressed in airway epithelial cells. In addition, we show that the nonreceptor tyrosine kinase c-Yes is contained within EBP50 protein complexes by association with YAP65. Subapical EBP50 protein complexes, containing the nonreceptor tyrosine kinase c-Yes, may regulate apical signal transduction pathways leading to changes in ion transport, cytoskeletal organization, or gene expression in epithelial cells.
Supplementary figures from Determinants of spring migration departure decision in a bat
Creators: name: Dechmann, Dina K. N.
name: M. Wikelski
name: D. Ellis-Soto
name: K. Safi
name: M. Teague O'Mara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Density distributions of weather data, correlation between body condition at capture and time until departure and year-round wind data.
Assembly of the Dystrophin-Associated Protein Complex Does Not Require the Dystrophin Cooh-Terminal Domain
Creators: name: Faulkner, John A.
name: Froehner, Stanley C.
name: Campbell, Kevin P.
name: Crosbie, Rachelle H.
name: Chamberlain, Jeffrey S.
name: Crawford, Gregory E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellular matrix through the dystrophin associated protein (DAP) complex. The COOH-terminal domain of dystrophin binds to two components of the DAP complex, syntrophin and dystrobrevin. To understand the role of syntrophin and dystrobrevin, we previously generated a series of transgenic mouse lines expressing dystrophins with deletions throughout the COOH-terminal domain. Each of these mice had normal muscle function and displayed normal localization of syntrophin and dystrobrevin. Since syntrophin and dystrobrevin bind to each other as well as to dystrophin, we have now generated a transgenic mouse deleted for the entire dystrophin COOH-terminal domain. Unexpectedly, this truncated dystrophin supported normal muscle function and assembly of the DAP complex. These results demonstrate that syntrophin and dystrobrevin functionally associate with the DAP complex in the absence of a direct link to dystrophin. We also observed that the DAP complexes in these different transgenic mouse strains were not identical. Instead, the DAP complexes contained varying ratios of syntrophin and dystrobrevin isoforms. These results suggest that alternative splicing of the dystrophin gene, which naturally generates COOH-terminal deletions in dystrophin, may function to regulate the isoform composition of the DAP complex.
Anomalous Hall conductivity and quantum friction
Creators: name: Středa, Pavel
name: Výborný, Karel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Anomalous Hall effect in very clean samples (high conductivity regime) is studied using a two-dimensional network model. We find that the off-diagonal conductivity comprises two parts: one which reflects the bulk properties as obtained by the Kubo formula and another which is sensitive to boundary conditions imposed on the network. The latter scales with the system width in the ideal case and for real-world samples, it will depend on the coherence length. It provides an alternative interpretation of the observed behaviour in the clean limit which is otherwise attributed to the skew scattering. We highlight analogies to friction in viscous fluids responsible for Couette flow.
description: to appear in PRB
Voluntary rewards mediate the evolution of pool punishment for maintaining public goods in large populations
Creators: name: Sasaki, Tatsuya
name: Uchida, Satoshi
name: Chen, Xiaojie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Computer Science and Game Theory (cs.GT)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Punishment is a popular tool when governing commons in situations where free riders would otherwise take over. It is well known that sanctioning systems, such as the police and courts, are costly and thus can suffer from those who free ride on other's efforts to maintain the sanctioning systems (second-order free riders). Previous game-theory studies showed that if populations are very large, pool punishment rarely emerges in public good games, even when participation is optional, because of second-order free riders. Here we show that a matching fund for rewarding cooperation leads to the emergence of pool punishment, despite the presence of second-order free riders. We demonstrate that reward funds can pave the way for a transition from a population of free riders to a population of pool punishers. A key factor in promoting the transition is also to reward those who contribute to pool punishment, yet not abstaining from participation. Reward funds eventually vanish in raising pool punishment, which is sustainable by punishing the second-order free riders. This suggests that considering the interdependence of reward and punishment may help to better understand the origins and transitions of social norms and institutions.
description: 20 pages, 4 figures, supplementary information (10 pages, 8 figures)
ESM 1 from Trust thy neighbour in times of trouble: background risk alters how tadpoles release and respond to disturbance cues.
Creators: name: Bairos-Novak, Kevin R.
name: Mitchell, Matthew D.
name: Crane, Adam L.
name: Chivers, Douglas P.
name: Ferrari, Maud C. O.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Further details on alarm, undisturbed, and disturbance cue preparation.
(3084) Monro Dixon Philipson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 6 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 6. Use of negative outcome and negative exposure controls to obtain estimated effects corrected for bias by omitted confounders.
A burst storm from the repeating FRB 20200120E in an M81 globular cluster
Creators: name: Nimmo, K.
name: Hessels, J. W. T.
name: Snelders, M. P.
name: Karuppusamy, R.
name: Hewitt, D. M.
name: Kirsten, F.
name: Marcote, B.
name: Bach, U.
name: Bansod, A.
name: Barr, E. D.
name: Behrend, J.
name: Bezrukovs, V.
name: Buttaccio, S.
name: Feiler, R.
name: Gawroński, M. P.
name: Lindqvist, M.
name: Orbidans, A.
name: Puchalska, W.
name: Wang, N.
name: Winchen, T.
name: Wolak, P.
name: Wu, J.
name: Yuan, J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The repeating fast radio burst (FRB) source FRB 20200120E is exceptional because of its proximity and association with a globular cluster. Here we report $60$ bursts detected with the Effelsberg telescope at 1.4 GHz. We observe large variations in the burst rate, and report the first FRB 20200120E `burst storm', where the source suddenly became active and 53 bursts (fluence $\geq 0.04$ Jy ms) occurred within only 40 minutes. We find no strict periodicity in the burst arrival times, nor any evidence for periodicity in the source's activity between observations. The burst storm shows a steep energy distribution (power-law index $α= 2.39\pm0.12$) and a bi-modal wait-time distribution, with log-normal means of 0.94$^{+0.07}_{-0.06}$ s and 23.61$^{+3.06}_{-2.71}$ s. We attribute these wait-time distribution peaks to a characteristic event timescale and pseudo-Poisson burst rate, respectively. The secondary wait-time peak at $\sim1$ s is $\sim50\times$ longer than the $\sim24$ ms timescale seen for both FRB 20121102A and FRB 20201124A -- potentially indicating a larger emission region, or slower burst propagation. FRB 20200120E shows order-of-magnitude lower burst durations and luminosities compared with FRB 20121102A and FRB 20201124A. Lastly, in contrast to FRB 20121102A, which has observed dispersion measure (DM) variations of $Δ{\rm DM} >1$ pc cm$^{-3}$ on month-to-year timescales, we determine that FRB 20200120E's DM has remained stable ($Δ{\rm DM} <0.15$ pc cm$^{-3}$) over $>10$ months. Overall, the observational characteristics of FRB 20200120E deviate quantitatively from other active repeaters, but it is unclear whether it is qualitatively a different type of source.
description: Accepted for publication in MNRAS
Cell to Cell Communication in Response to Mechanical Stress via Bilateral Release of Atp and Utp in Polarized Epithelia
Creators: name: Boucher, Richard C.
name: Steinberg, Thomas H.
name: Homolya, László
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Airway epithelia are positioned at the interface between the body and the environment, and generate complex signaling responses to inhaled toxins and other stresses. Luminal mechanical stimulation of airway epithelial cells produces a propagating wave of elevated intracellular Ca2+ that coordinates components of the integrated epithelial stress response. In polarized airway epithelia, this response has been attributed to IP3 permeation through gap junctions. Using a combination of approaches, including enzymes that destroy extracellular nucleotides, purinergic receptor desensitization, and airway cells deficient in purinoceptors, we demonstrated that Ca2+ waves induced by luminal mechanical stimulation in polarized airway epithelia were initiated by the release of the 5′ nucleotides, ATP and UTP, across both apical and basolateral membranes. The nucleotides released into the extracellular compartment interacted with purinoceptors at both membranes to trigger Ca2+ mobilization. Physiologically, apical membrane nucleotide-release coordinates airway mucociliary clearance responses (mucin and salt, water secretion, increased ciliary beat frequency), whereas basolateral release constitutes a paracrine mechanism by which mechanical stresses signal adjacent cells not only within the epithelium, but other cell types (nerves, inflammatory cells) in the submucosa. Nucleotide-release ipsilateral and contralateral to the surface stimulated constitutes a unique mechanism by which epithelia coordinate local and distant airway defense responses to mechanical stimuli.
{epub download} La méthode de lecture 100 % syllabique Larousse  - Idéal pour apprendre à lire ! Dès 5 ans
Creators: name: Harden
Publisher: name: Zenodo
Year: 2024

description: La méthode de lecture 100 % syllabique Larousse - Idéal pour apprendre à lire ! Dès 5 ans pan Hélène Heffner, Giulia Levallois

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La méthode de lecture 100 % syllabique Larousse - Idéal pour apprendre à lire ! Dès 5 ans

Hélène Heffner, Giulia Levallois

Nb. de pages: 216

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782035955548

Editeur: Larousse

Date de parution: 2018

 

 

 

Anglais manuel pdf téléchargement gratuit La méthode de lecture 100 % syllabique Larousse - Idéal pour apprendre à lire ! Dès 5 ans 9782035955548

 

Overview

Une méthode progressive et idéale pour apprendre à lire ! Une méthode innovante et progressive conçue par des enseignantes de CP. Un schéma, des conseils et des fichiers audio pour apprendre à bien prononcer les sons. Un mot référent pour mémoriser le son étudié. Des conseils pour comprendre les particularités de certains sons. Des exercices pour reconnaître les lettres. Un rappel des différentes écritures de la lettre associée au son. De nombreux exercices de discrimination auditive. Des activités de lecture progressive pour s'exercer à lire des syllabes, des mots et des phrases. Des activités de graphisme.
(3085) Robert Redman Read
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrins Regulate the Linkage between Upstream and Downstream Events in G Protein-coupled Receptor Signaling to Mitogen-activated Protein Kinase
Creators: name: Boyer, José L.
name: Juliano, R. L.
name: Short, Sarah M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs) can both activate mitogen-activated protein kinase (MAPK), a critical intermediate in the transduction of proliferative signals. Numerous observations have demonstrated that integrin-mediated cell anchorage can regulate the efficiency of signaling from RTKs to MAPK. Recently, a relationship between integrins and GPCR signaling has also emerged; however, little is understood concerning the mechanisms involved. Here, we investigate integrin regulation of GPCR signaling to MAPK, focusing on the P2Y class of GPCRs that function through activation of phospholipase Cbeta. P2Y receptor signaling to the downstream components mitogen-activated protein kinase kinase and MAPK is highly dependent on integrin-mediated cell anchorage. However, activation of upstream events, including inositol phosphate production and generation of calcium transients, is completely independent of cell anchorage. This indicates that integrins regulate the linkage between upstream and downstream events in this GPCR pathway, just as they do in some aspects of RTK signaling. However, the P2Y pathway does not involve cross-activation of a RTK, nor a role for Shc or c-Raf; thus, it is quite distinct from the classical RTK-Ras-Raf-MAPK cascade. Rather, integrin-modulated P2Y receptor stimulation of MAPK depends on calcium and on the activation of protein kinase C.
Phase transition oscillations induced by a strongly focused laser beam
Creators: name: Devailly, Clémence
name: Crauste-Thibierge, Caroline
name: Petrosyan, Artyom
name: Ciliberto, Sergio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report here the observation of a surprising phenomenon consisting in a oscillating phase transition which appears in a binary mixture, PMMA/3-octanone, when this is enlightened by a strongly focused infrared laser beam. PMMA/3-octanone has a UCST (Upper Critical Solution Temperature) which presents a critical point at temperature Tc = 306.6 K and volume fraction $ϕ$c = 12.8 % [Crauste et al., ArXiv 1310.6720, 2012]. This oscillatory phenomenon appears because of thermophoretic and electrostriction effects and non-linear diffusion. We analyze these oscillations and we propose a simple model which includes the minimal ingredients to produce the oscillatory behavior. Phase transitions in binary mixtures are still a widely studied subject, specifically near the critical point where several interesting and not completely understood phenomena may appear, among them we recall the critical Casimir forces [2],[3], confinement effects [4], [5] and out-of-equilibrium dynamics after a quench. The perturbation of the binary mixtures by mean of external fields is also an important and recent field of investigation [6]. For example, a laser can induce interesting phenomena in demixing binary mixtures because the radiation pressure can deform the interface between the two phases and it can be used to measure the interface tension [7]. Depending on the nature of the binary mixtures, laser illumination can also lead to a mixing or demixing transition. In ref.[8], focused infrared laser light heats the medium initially in the homogeneous phase and causes a separation in the LCST (Low Critical Solution Temperature) system. The radiation pressure gradients in a laser beam also contribute in the aggregation of polymers , thus producing a phase transition. The local heating may induce thermophoretic forces which attract towards the laser beam one of the binary-mixture components [9]. Other forces like electrostriction can also be involved [10]. In this letter, we report a new phenomenon, which consists in an oscillating phase transition induced by a constant illumination from an infrared laser beam in the heterogeneous region of an UCST (Upper Critical Solution Temperature) binary mixture. Oscillation phenomena in phase transition have already been reported in slow cooling UCST [11],[12] but as far as we know, never induced by a stationary laser illumination. After describing our experimental setup , we will present the results. Then we will use a very simplified model which contains the main necessary physical ingredients to induce this oscillation phenomenon.
Descargar PDF HOOKED: UNA HISTORIA DE NUNCA JAMÁS.
Creators: name: Mysliwiec
Publisher: name: Zenodo
Year: 2024

description: HOOKED: UNA HISTORIA DE NUNCA JAMÁS. de EMILY MCINTIRE

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Ficha técnica

HOOKED: UNA HISTORIA DE NUNCA JAMÁS.

EMILY MCINTIRE

Número de páginas: 384

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419501745

Editorial: MONTENA

Año de edición: 2023

 

 

 

 

 

Ebook descarga gratuita deutsch HOOKED: UNA HISTORIA DE NUNCA JAMÁS. de EMILY MCINTIRE (Literatura española) PDF 9788419501745

 

Overview

Adéntrate en elretellingmásoscuroy deliciosode Peter Pan que haconquistadoTikTok.Desea venganza, pero a ella la desea todavía más...James ha tenido siempre un único objetivo: acabar con Peter Michaels, su enemigo. Un día, la hija de Peter, Wendy, de solo veinte años, entra en el bar de James y este ve la ocasión: la seducirá y la utilizará para vengarse. Parece el plan perfecto... hasta que todo empieza a desmoronarse. De pronto, James tiene que encontrar al traidor que se esconde entre los suyos, y su plan de venganza se complica cuando Wendy empieza a ser mucho más que un peón en su juego.Wendy siempre ha estado protegida del mundo por su padre, tan frío como adinerado. Pero una noche espontánea con amigas desemboca en una relación amorosa intensa y adictiva con el problemático James. Wendy sabe que James es peligroso, pero no puede evitar desearlo y, a medida que la relación se intensifica y descubre más cosas sobre el turbio mundo en el que se mueve, ya no sabe si se está enamorando del hombre al que conoce como James... o del monstruo al que llaman Garfio.Advertencia:Hooked es un romance oscuro contemporáneo. Incluye contenido sexual explícito, consumo de drogas y escenas violentas, por lo que no se recomienda a menores de 18 años. Para más información, puedes consultar la web de la autora.
ESM 1 from Trust thy neighbour in times of trouble: background risk alters how tadpoles release and respond to disturbance cues
Creators: name: Bairos-Novak, Kevin R.
name: Mitchell, Matthew D.
name: Crane, Adam L.
name: Chivers, Douglas P.
name: Ferrari, Maud C. O.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Further details on alarm, undisturbed, and disturbance cue preparation.
Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells
Creators: name: Howell, B. J.
name: Hoffman, D. B.
name: Fang, G.
name: Salmon, E. D.
name: Murray, A. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The spindle checkpoint prevents errors in chromosome segregation by inhibiting anaphase onset until all chromosomes have aligned at the spindle equator through attachment of their sister kinetochores to microtubules from opposite spindle poles. A key checkpoint component is the mitotic arrest–deficient protein 2 (Mad2), which localizes to unattached kinetochores and inhibits activation of the anaphase-promoting complex (APC) through an interaction with Cdc20. Recent studies have suggested a catalytic model for kinetochore function where unattached kinetochores provide sites for assembling and releasing Mad2–Cdc20 complexes, which sequester Cdc20 and prevent it from activating the APC. To test this model, we examined Mad2 dynamics in living PtK1 cells that were either injected with fluorescently labeled Alexa 488-XMad2 or transfected with GFP-hMAD2. Real-time, digital imaging revealed fluorescent Mad2 localized to unattached kinetochores, spindle poles, and spindle fibers depending on the stage of mitosis. FRAP measurements showed that Mad2 is a transient component of unattached kinetochores, as predicted by the catalytic model, with a t1/2 of ∼24–28 s. Cells entered anaphase ∼10 min after Mad2 was no longer detectable on the kinetochores of the last chromosome to congress to the metaphase plate. Several observations indicate that Mad2 binding sites are translocated from kinetochores to spindle poles along microtubules. First, Mad2 that bound to sites on a kinetochore was dynamically stretched in both directions upon microtubule interactions, and Mad2 particles moved from kinetochores toward the poles. Second, spindle fiber and pole fluorescence disappeared upon Mad2 disappearance at the kinetochores. Third, ATP depletion resulted in microtubule-dependent depletion of Mad2 fluorescence at kinetochores and increased fluorescence at spindle poles. Finally, in normal cells, the half-life of Mad2 turnover at poles, 23 s, was similar to kinetochores. Thus, kinetochore-derived sites along spindle fibers and at spindle poles may also catalyze Mad2 inhibitory complex formation.
(3086) John Robert Reid
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1
Creators: name: Assoian, Richard K.
name: Aplin, Andrew E.
name: Stewart, Sheryl A.
name: Juliano, R. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Integrin-mediated adhesion to the extracellular matrix permits efficient growth factor-mediated activation of extracellular signal–regulated kinases (ERKs). Points of regulation have been localized to the level of receptor phosphorylation or to activation of the downstream components, Raf and MEK (mitogen-activated protein kinase/ERK kinase). However, it is also well established that ERK translocation from the cytoplasm to the nucleus is required for G1 phase cell cycle progression. Here we show that phosphorylation of the nuclear ERK substrate, Elk-1 at serine 383, is anchorage dependent in response to growth factor treatment of NIH 3T3 fibroblasts. Furthermore, when we activated ERK in nonadherent cells by expression of active components of the ERK cascade, subsequent phosphorylation of Elk-1 at serine 383 and Elk-1–mediated transactivation were still impaired compared with adherent cells. Elk-1 phosphorylation was dependent on an intact actin cytoskeleton, as discerned by treatment with cytochalasin D (CCD). Finally, expression of active MEK failed to predominantly localize ERK to the nucleus in suspended cells or adherent cells treated with CCD. These data show that integrin-mediated organization of the actin cytoskeleton regulates localization of activated ERK, and in turn the ability of ERK to efficiently phosphorylate nuclear substrates.
(3088) Mary A [Dixon]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Semi-Annihilation of Fermionic Dark Matter
Creators: name: Bandyopadhyay, Priyotosh
name: Choudhury, Debajyoti
name: Sachdeva, Divya
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The continued non-observation of events emanating from dark matter (DM) annihilations in various direct and indirect detection experiments calls into question the mechanism for determining the relic density of a weakly interacting massive particle. However, if the relic density is determined primarily by a semi-annihilation process, as opposed to the usual annihilation, this tension can be ameliorated. Here, we investigate a Z3 symmetric effective field theory incorporating a fermionic dark matter that semi-annihilates to right-handed neutrinos (RHN). The dynamics of the RHN and the impact of its late decays are also scrutinised while obtaining the correct DM relic. Finally, indirect detection bounds on the semi-annihilation cross-sections are drawn from the gamma-ray observations in the direction of Dwarf Spheroidal Galaxies (Fermi-LAT), and including the projections obtained for the H.E.S.S. and the CTA detectors.
description: 22 pages, 7 figures
A New Methodology of Spatial Crosscorrelation Analysis
Creators: name: Chen, Yanguang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: The idea of spatial crosscorrelation was conceived of long ago. However, unlike the related spatial autocorrelation, the theory and method of spatial crosscorrelation analysis have remained undeveloped. This paper presents a set of models and working methods for spatial crosscorrelation analysis. By analogy with Moran's index newly expressed in a spatial quadratic form and by means of mathematical reasoning, I derive a theoretical framework for geographical crosscorrelation analysis. First, two sets of spatial crosscorrelation coefficients are defined, including a global spatial crosscorrelation coefficient and a set of local spatial crosscorrelation coefficients. Second, a pair of scatterplots of spatial crosscorrelation is proposed, and different scatterplots show different relationships between correlated variables. Based on the spatial crosscorrelation coefficient, Pearson's correlation coefficient can be decomposed into two parts: direct correlation (partial crosscorrelation) and indirect correlation (spatial crosscorrelation). As an example, the analytical process is applied to the relationships between China's urbanization and economic development. Spatial crosscorrelation and spatial autocorrelation can complement one another, and the spatial crosscorrelation scatterplots can be used to reveal the causality inside a self-organized system. The spatial crosscorrelation models will play a useful role in future geographical spatial analysis.
description: 24 pages, 5 figures, 4 tables
ESM 2 from Trust thy neighbour in times of trouble: background risk alters how tadpoles release and respond to disturbance cues.
Creators: name: Bairos-Novak, Kevin R.
name: Mitchell, Matthew D.
name: Crane, Adam L.
name: Chivers, Douglas P.
name: Ferrari, Maud C. O.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Diagram illustrating the experimental design used. Boxes with a red outline indicate high background risk (HR) (e.g. cues from high background risk individuals, or high-risk individuals themselves), while boxes in blue indicate low background risk (LR). The circle-shaped cue represents undisturbed cue (UC) taken from tadpoles after 10 minutes without disturbance, while the star-shaped cue represents disturbance cues (DC) extracted by chasing individuals using a glass rod for 1 minute. Tadpoles were either used for cue extraction or tested once and were subsequently removed from the experiment.
Knotted 4-regular graphs: polynomial invariants and the Pachner moves
Creators: name: Cartin, Daniel
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In loop quantum gravity, states of quantum geometry are represented by classes of knotted graphs, equivalent under diffeomorphisms. Thus, it is worthwhile to enumerate and distinguish these classes. This paper looks at the case of 4-regular graphs, which have an interpretation as objects dual to triangulations of three-dimensional manifolds. Two different polynomial invariants are developed to characterize these graphs -- one inspired by the Kauffman bracket relations, and the other based on quandles. How the latter invariant changes under the Pachner moves acting on the graphs is then studied.
description: 25 pages; 27 figures; corrected both skein relation (1b) in Section IV and discussion after Table I, with no change in the conclusions
[PDF/Kindle] Swimming to Freedom: My Escape from China and the Cultural Revolution by Kent Wong
Creators: name: Cox
Publisher: name: Zenodo
Year: 2024

description: Swimming to Freedom: My Escape from China and the Cultural Revolution by Kent Wong

 

 

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Swimming to Freedom: My Escape from China and the Cultural Revolution

Kent Wong

Page: 320

Format: pdf, ePub, mobi, fb2

ISBN: 9781419751509

Publisher: Abrams Press

 

Free book download ipod Swimming to Freedom: My Escape from China and the Cultural Revolution by Kent Wong

A deeply personal, heart-wrenching memoir of the author's upbringing in Communist China during the Cultural Revolution and his tenacious flight to freedom against all odds When Kent Wong was a young boy, his father, a patriotic Chinese official in the customs office in Hong Kong, joined an insurrection at work and returned with the family to the newly established People’s Republic of China. Hailed as heroes, they settled in the southern city of Canton. But Mao’s China was dangerous and unstable, with landlords executed en masse and millions dying of starvation during the Great Leap Forward. Kent Wong’s Swimming to Freedom is a memoir of a childhood amid revolutionary times, where boyish adventures and school days mixed with dire poverty and political persecution, and a moving story of an inextinguishable yearning to be free. Mao’s Hundred Flower Campaign ensnared Kent’s father. A decade later the Cultural Revolution closed schools, plunged the country into chaos, and scattered Kent and his sisters to disparate villages where they struggled to eke out a bare existence. Kent began to realize that with higher education closed to him (as the son of a “capitalist rightist”), he had no future in China. So, when he hooked up with a dissident underground and heard about fellow countrymen braving extraordinary hardship to reach freedom by swimming across miles of open water to Hong Kong, he decided to risk his life for a better future. Swimming to Freedom is an extraordinary account of a largely unknown chapter in history, when an estimated half million “Freedom Swimmers” risked everything to escape hardship and oppression. It is a gripping memoir and a moving testament to the human spirit.

Sharen's review of Swimming to Freedom: My Escape fromAmazon.com New Releases: The best-selling new & futureSwimming to Freedom : My Escape from China - Books KinokuniyaSwimming to Freedom: My Escape from China - BookshopBooks | chapters.indigo.caWe salute the young boys and girls who made the escape to frWe are slaves who have been betrayedBuy Swimming to Freedom: My Escape from China and theSwimming to Freedom (My Escape from China and the CulturalBuy Swimming to Freedom: My Escape from China and the CulturalComing Soon - ABRAMS ABRAMS | Page 5 - ABRAMS BooksSwimming to Freedom: My Escape from China and the
Linking a universal gas density profile to the core-excised X-ray luminosity in galaxy clusters up to z ~ 1.1
Creators: name: Pratt, G. W.
name: Arnaud, M.
name: Maughan, B. J.
name: Melin, J. -B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the regularity of galaxy cluster gas density profiles and the link to the relation between core-excised luminosity, LXc, and mass from the Yx proxy, MYx, for 93 SZE-selected objects. The sample spans masses M500=[0.5 - 20] x 10e14 Msun, and lies at redshifts 0.05
description: 24 pages, 13 figures; arXiv version includes corrections to Eqns. 3 and 18 published in Corrigendum
{pdf download} The 15-Minute Artist: The Quick and Easy Way to Draw Almost Anything by Catherine V. Holmes
Creators: name: Mart
Publisher: name: Zenodo
Year: 2024

description: The 15-Minute Artist: The Quick and Easy Way to Draw Almost Anything by Catherine V. Holmes

 

 

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The 15-Minute Artist: The Quick and Easy Way to Draw Almost Anything

Catherine V. Holmes

Page: 160

Format: pdf, ePub, mobi, fb2

ISBN: 9781640210431

Publisher: Sixth&Spring

 

Ebook download epub format The 15-Minute Artist: The Quick and Easy Way to Draw Almost Anything 9781640210431

Overview

From all-star sneakers to elephants, you can learn to draw anything . . . in just 15 minutes!   If you want to draw but think you don’t have the time to learn—or feel too intimidated to start–15-Minute Artist invites you to jump in. Bestselling author Catherine Holmes (How to Draw Cool Stuff) provides more than 60 step-by-step projects for depicting animals, food, plants, household items, and more—and you can complete each one in just 15 minutes. Her tutorials break the process down so you can achieve quick, satisfying results. In addition to pencil renderings, Catherine demonstrates techniques for working with charcoal, pen, and colored pencil, and provides tips and sidebars on blending, texture, perspective, and shading.
(3083) Florence Dixon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ca II Triplet Spectroscopy of Small Magellanic Cloud Red Giants. III. Abundances and Velocities for a Sample of 14 Clusters
Creators: name: Parisi, M. C.
name: Geisler, D.
name: Clariá, J. J.
name: Villanova, S.
name: Marcionni, N.
name: Sarajedini, A.
name: Grocholski, A. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We obtained spectra of red giants in 15 Small Magellanic Cloud (SMC) clusters in the region of the CaII lines with FORS2 on the Very Large Telescope (VLT). We determined the mean metallicity and radial velocity with mean errors of 0.05 dex and 2.6 km/s, respectively, from a mean of 6.5 members per cluster. One cluster (B113) was too young for a reliable metallicity determination and was excluded from the sample. We combined the sample studied here with 15 clusters previously studied by us using the same technique, and with 7 clusters whose metallicities determined by other authors are on a scale similar to ours. This compilation of 36 clusters is the largest SMC cluster sample currently available with accurate and homogeneously determined metallicities. We found a high probability that the metallicity distribution is bimodal, with potential peaks at -1.1 and -0.8 dex. Our data show no strong evidence of a metallicity gradient in the SMC clusters, somewhat at odds with recent evidence from CaT spectra of a large sample of field stars Dobbie et al. (2014). This may be revealing possible differences in the chemical history of clusters and field stars. Our clusters show a significant dispersion of metallicities, whatever age is considered, which could be reflecting the lack of a unique AMR in this galaxy. None of the chemical evolution models currently available in the literature satisfactorily represents the global chemical enrichment processes of SMC clusters.
description: 49 pages, 15 figures. Accepted for publication in AJ
[Kindle] NEUROANATOMIA DE BOLSILLO descargar gratis
Creators: name: Davis
Publisher: name: Zenodo
Year: 2024

description: NEUROANATOMIA DE BOLSILLO de DOUGLAS J. GOULD

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NEUROANATOMIA DE BOLSILLO

DOUGLAS J. GOULD

Número de páginas: 128

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788416004119

Editorial: LIPPINCOTT WILLIAMS AND WILKINS. WOLTERS KLUWER HEALTH

Año de edición: 2014

 

 

 

 

 

Descargar ebooks en formato pdb NEUROANATOMIA DE BOLSILLO CHM PDF en español 9788416004119 de DOUGLAS J. GOULD

 

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ESTE LIBRO ESTA DISEÑADO PARA ESTUDIANTES QUE TIENEN EL TIEMPO JUSTO