cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On the robustness of goodness-of-fit tests for copulas
Creators: name: Weiß, Gregor N. F.
Publisher: name: Technische Universität Dortmund
Year: 2011
Subjects: subject: copulas
subject: dependence structures
subject: goodness-of-fit-testing
subject: robustness
subject: 310
subject: 330
subject: 620

description: This paper is the first to analyze the robustness of goodness-of-fit for bivariate elliptical and archimedean copulas. To assess the tests’ robustness, we consider perturbations and outliers both in the dependence structure and the observations from the joint distribution. The Monte Carlo simulations show that independent of the underlying true copula, the GoF-test or chosen test statistic, even minor contaminations of the data can lead to a significant decrease in the GoF-tests’ power. In order to robustify the GoF-tests, several methods for the detection of multivariate outliers are applied to the contaminated data. The results show that the exclusion of outliers can have a beneficial effect on the power of the GoF-tests. Moreover, this robustification strategy improves the power of GoF-testing when used to identify the main component of a mixture copula. In the empirical risk management application, the practical usefullness of this strategy is exemplified for a set of bivariate portfolios.
description: Discussion Paper / SFB 823;40/2011
High temperature pyrolysis of fused oxadiazolones
Creators: name: Smith, Reginald James
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Robinson-Trautman solutions of Einstein's equations
Creators: name: Singleton, David Barry
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Effects of Low Dose Ionizing Radiation on the Hematological Parameters in Medical Imaging and Therapeutic Technologists Working in Selected Governmental Hospitals, Addis Ababa, Ethiopia
Creators: name: Giragn, Eden
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2016

description: Background: Exposure to ionizing radiations including x-rays and gamma rays leads to abnormal hematological findings, cancer (including leukaemia), birth defects in the future children of exposed parents, and cataracts. There is no published report in Ethiopia addressing the effect of low dose radiation on hematological parameters. Objective: To compare the hematological profile such as (RBCs count, RBC indices, Hb, Hct levels, WBCs, platelets count and peripheral morphology) of medical imaging and therapeutic technologists and controls of selected Governmental Hospitals in Addis Ababa, Ethiopia Method: A comparative cross-sectional study with 182 participants in the period October 2015 to June 2016 was carried out. Of them, 91 were radiation exposed and 91 were controls. Hematological parameters were analyzed using Sysmex XT-2000i. Peripheral blood morphology was done from a stained smear. Data was entered, cleaned and analyzed using SPSS version 21. Student t-test was used to compare the hematological parameter means between the two groups, the exposed and the control. Bivariate correlation statistics was used to draw association between the dependent and independent variables. P values ≤ 0.05 were considered statistically significant. Data was cleaned, entered and analysed using SPSS 21. Result: Mean values of White Blood Cells, Mean Cell Hemoglobin, Mean Platelet Volume, Platelet Distribution Width, Platelet Large Cell Ratio, Lymphocytes, Monocytes and Basophils have shown significant difference from the control group. The mean MCH, PDW, P-LCR were higher while WBC, MPV, LYMPH, MONO, and BASO were lower in the exposed group. Atypical lymphocytes were significantly higher in the exposed group; 65/91 of the exposed and only 7 of the non-exposed group have such abnormal picture. There were larger effects on the lymphocyte of exposed workers with high number of atypical lymphocytes. A smaller but not negligible effect was noted on white blood cells and medium effects on mean cell haemoglobin, platelet distribution width, mean platelet volume, platelet large cell ratio, Basophil and monocytes. Conclusion: It is not deniable that low dose ionizing radiation is imposing impact on the haematological as well as immunological system of medical imaging and therapeutic technologists as there are larger effects on the lymphocyte and basophil subsets of exposed workers. Key words: ionizing radiation, hematological parameters, atypical lymphocyte
Advanced clustering methods for identifying bioactive molecular conformations
Creators: name: Christoforou, Emmanouil
name: Cournia, Zoe
name: Emiris, Ioannis Z.
Publisher: name: Zenodo
Year: 2018

description: Angiotensin II is a hormone, which plays a vital role in the regulation of blood pressure, in the conservation of total blood volume, and salt homeostasis. Previous studies of AII bioactive conformation, when bound to the AT1 receptor, appeared to have diverging results making it important to study the intermolecular interactions of AII. In this work we investigate the bioactive conformation of AII, using multiple trajectories from simulations, with Markov State Models (MSM). Also, we validate the efficiency of an inverted-quantized k-means algorithm (IQ-means), as a fast approximate clustering technique, on data from trajectories of MD simulations with reasonable trade-offs between time and accuracy. Finally, we experiment on Markov State Models using various clustering techniques for the generation of microstates (IQ-means), macrostates and for the selection of the macrostate representatives (GROMOS).
Statistical and ascertainment problems in human genetics
Creators: name: Shute, Nereda Christine Evelyn
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Multi-Drug Resistant Bacterial Isolates Among Septicemia Suspected Under Five Children In Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia
Creators: name: Mitiku, Mequanint
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: Background: Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality among pediatric patients. Emergence of drug resistance in high classes of antibiotics among the bacterial pathogens is another issue of the public health concern. Objective: To determine Multi-Drug Resistant Bacterial Isolates among Septicemia Suspected under Five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia. Methods: Across-sectional study was conducted from September 2017 to June 2018 among pediatric patients with febrile illness aged under five in Tikur Anbesa Specialized Hospital. Three hundred forty blood samples were collected and processed following standard microbiological techniques and culture was performed using BacT/Alert machine in combination with conventional method. Antimicrobial susceptibility testing of the isolates was performed by Kirby-Bauer disc diffusion method and MIC technique Result: A total of 137(40.2%) bacterial pathogens were isolated from 340 pediatric patients suspected of BSI with febrile illness. Of these isolates, about 46% of them were Gram positive and 54% were Gram negative bacteria. Of the isolates 43 (31.4%) Klebsiella pneumoniae, 29(21.2%) S. aureus, 15(10.9%) CoNS and 12 (8.7%) Acinitobactor species were the most frequently isolated pathogens. The overall prevalence of MDR 51.1%, CRE 30.5% and ESBL 25.4% were alarmingly high in bacterial isolates. Klebsiella pneumoniae isolates were 95.6% MDR, 23.7% ESBL, and 27.1% CRE dominated followed by Staphylococcus aureus 55.2% MRSA in children. Conclusion and Recommendation: In this study, Klebsiella pneumoniae and S. aureus are common pathogens associated with BSI in pediatrics with high antimicrobial resistance. High frequency of staphylococcus species and MRSA were a treat of children. Emergency of an intermediate vancomycin susceptibility of an isolate among MRSA calls an attention on treatment options. ESBL producing organisms were common in Klebsiella species and Escherichia coli isolates. Since most of isolates exhibit multidrug resistant, routine in-vitro susceptibility of antimicrobials and update antibiogram for treatment is essential.
X-Ray Resonant Scattering Study of the Quadrupolar Order in UPd3
Creators: name: Yakhou, F.
name: McEwen, K. A.
name: McMorrow, D. F.
name: Rønnow, H. M.
name: Steigenberger, U.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
The ecology of billabong fish communities of the River Murray, with a focus on the interactions of European perch (Perch fluviatilis)
Creators: name: Shirley, Michael John
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Verification and comparison of Sysmex KX-21N, Cell-Dyn 1800 and Horiba ABX Micros ES 60 automated hematology analyzers at Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia
Creators: name: Kebede, Henok
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: Background: Laboratory testing plays a crucial role in the detection, diagnosis and treatment of disease in patients. Analytical evaluation of a new analyzer or method should be done in order to confirm the declared specifications before its introduction into the routine use. Agreement of all automated hematology analyzers must be carried out in all laboratories. But, the practice of using automated analyzers interchangeably without evaluation is common in our country including Tikur Anbessa specialized hospital (TASH). Objective: To verify performance and compare agreement of Cell-Dyn 1800, Sysmex KX-21N and Horiba ABX micros ES 60 hematology analyzers found in TASH. Methods: A cross sectional study was conducted to verify performance and assess agreement between Cell-Dyn 1800, Sysmex KX-21N and Horiba ABX micros ES 60 hematology analyzers at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. The study period was from February to May 2017. According to the CLSI guideline a total of 267 samples were analyzed in duplicates on the three analyzers to verify and compare them. Data cleaning and analysis were performed by Microsoft excel 2007 and SPSS version 20. Result: We found that minimal carryover (< 0.5%) and excellent linearity for white blood cell, hemoglobin, red blood cell and platelet (r > 0.999). Precision was good for all major CBC parameters with % CV< 2.0. Agreement between most of the parameters of the analyzers lies in the limits of agreement for more than 95% of cases according to the Bland-Altman plot analysis. Pearson correlation and linear regression graph showed that the three analyzers were well correlated (r > 0.900) for major CBC parameters. The correlation of WBC differential- neutrophil and lymphocyte were excellent (r > 0.920). Poor correlation was observed in mixed cells (r=0.005) especially in the high levels between Horiba and Sysmex. There was also moderate correlation in mean platelet volume (MPV) between analyzers of Horiba and Sysmex (r= 0.593 and r=0.572) at normal and high levels respectively. Conclusion: The overall performance of the three analyzers is excellent. They agree well with each other and can be used interchangeably with care in mixed cells and MPV. Key words: Method comparison, performance evaluation, verification of hematology analyzers Sysmex KX-21, Horiba ABX micros ES 60, Cell-Dyn 1800, hematology
Nuclear Spin Driven Quantum Relaxation in LiY0.998Ho0.002F4
Creators: name: Barbara, B.
name: Giraud, R.
name: Mailly, D.
name: Tkachuk, A. M.
name: Wernsdorfer, W.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
An analysis of ordered and orderable fields by Dedekind and Hölder cuts
Creators: name: Sherman, Brian Francis
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Assessment of Platelet to Lymphocyte ratio and Neutrophil to Lymphocyte ratio as potential biomarkers in patients with rheumatoid arthritis at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Creators: name: Abate, Senait
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: Background: Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune disease involving inflammation of synovial joints. The interest in the study of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio( NLR) has grown recently because they have been found to be predictive of the prognosis of patients with diverse inflammatory and ischemic conditions and these ratios are easily calculated from hematology analyzer printout. However, in Ethiopia no published study is available in this regard. Objective: This study aimed to assess platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) as potential biomarkers in patients with rheumatoid arthritis at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia from April-July, 2019. Method: This comparative cross-sectional study enrolled 61 newly diagnosed adult rheumatoid arthritis patients and 61 sex and age matched healthy controls. Blood sample was collected from all study participants using convenient sampling technique. CBC was measured using Mindray BC5300 hematology analyzer and BD sedintainer was used for ESR measurement, while RF and CRP were done based on latex agglutination method. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. Receiver operating characteristic (ROC) curves was used to evaluate the performance of PLR and NLR. P values less than 0.05 was taken as statistically significant. Result: The median PLR and NLR were significantly increased in RA patients compared with healthy controls 195(IQR, 150-242) vs 125(105-150), P<0.05; 2.4(1.85-3.5) vs. 1.6(1.3-1.9), P<0.05 respectively). ROC curves analysis showed that PLR had area under the curve(AUC) of 0.859 with 85.2% sensitivity and 66% specificity as a marker of rheumatoid arthritis and NLR had AUC of 0.80 with sensitivity and specificity of 78.3% and 68% respectively. Conclusion: There was a statistically significant increment in the level of Platelet to lymphocyte ratio and Neutrophil to lymphocyte ratio among new RA patients compared with healthy controls. In addition ROC curves analysis revealed a good diagnostic performance. Therefore, PLR and NLR can be added to routine diagnostic parameters as indicators in the assessment of rheumatoid arthritis patients. So, further studies with larger numbers of RA cases is needed to better understand the role of PLR and NLR in patients with RA.
Signatures of Carrier-Wave Rabi Flopping in GaAs
Creators: name: Kärtner, F. X.
name: Morgner, U.
name: Mücke, O. D.
name: Tritschler, T.
name: Wegener, M.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
ERTAKLAR VOSITASIDA BOLALARNING OG'ZAKI MULOQOT MADANIYATINI  TARBIYALASH
Creators: name: Murodova, Farangis
name: Hamdamova, Shahnoza
Publisher: name: Zenodo
Year: 2024

description: O‘zbekiston Respublikasi ta’lim tizimida bugungi kunda  o‘z fikrini ta’sirchan yetkazishda  tushunarli, mantiqiy, aniq, ravon nutqqa ega bo‘lgan kadrlarni tayyorlash kabi masalalar dolzarb bo‘lib kelmoqda.
Künstliche Intelligenz in der Lehre
Creators: name: Stracke, Christian M.
name: Opel, Simone
name: Mersmann-Hoffmann, Heike
Publisher: name: Zenodo
Year: 2024

description: Präsentation des Deutschen Netzwerks "Ethische Nutzung von KI" gehalten von Christian M. Stracke, Simone Opel und Heike Mersmann-Hoffmann auf der Konferenz Learning AID 2024 am 2.9.2024 in Bochum:

Sie stellt insbesondere die Arbeit der Deutschen Netzwerks seit März 2023 vor sowie dessen Handreichung, die jetzt in der Version 1.1 überarbeitet und veröffentlicht wurde.

Mehr Information auf der Webseite des Deutschen Netzwerks "Ethische Nutzung von KI":

https://ethischeki.ecompetence.eu
Some fluorine-substituted silyl derivatives of the elements
Creators: name: Schrieke, Roy Robert
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Schutz vor Cybermobbing: Kompetenzerweiterung bei Schüler*innen durch die Schulsozialarbeit
Creators: name: Kilchmann, Till
name: Ott, Nadin Lynn
Publisher: name: Zenodo
Year: 2022

description: Das virtuelle und das reale Leben sind zwei Sphären, die sich in zunehmendem Masse vermischen. Sozialen Medien sind besonders für Kinder und Jugendliche in der Schweiz ein wichtiger Bestandteil des Lebens und haben Einfluss auf ihre Entwicklung. Wo online Freundschaften und Liebesbeziehungen ausgelebt werden können, befinden sich auch Gefahren. Eine besonders schwerwiegende davon ist Cybermobbing. Auslöser von Cybermobbing können bspw. ein Mangel an Selbst-, Sozial- und Medienkompetenz sein. Dazu wurde diese Forschungsarbeit mit dem Fokus auf Schulen des Kantons Nidwalden verfasst. Die vorliegende Arbeit beschäftigt sich mit der Frage, inwiefern die Schulsozialarbeit Nidwalden durch die Erweiterung von Selbst-, Sozial- und Medienkompetenzen der Schüler*innen Schutz vor Cybermobbing bieten kann. Um die Forschungsfrage zu beantworten, wurden vier qualitative Experteninterviews mit fünf Expert*innen der kantonalen Schulsozialarbeit durchgeführt. Die Schlussfolgerung daraus ist, dass die Vermittlung der Kompetenzbereiche nicht nur bei den Schulsozialarbeitenden Nidwalden liegt, sondern auch bei den Eltern und Lehrpersonen. Die Schulsozialarbeit Nidwalden hat bereits einige Methoden und Ansätze ausgearbeitet, um die Kompetenzbereiche der Schüler*innen zu erweitern. Des Weiteren zieht die Schulsozialarbeit Nidwalden einige externe Ressourcen herbei. In der vorliegenden Arbeit wurde festgestellt, dass die Verantwortung zum Schutz vor Cybermobbing ein mehrstufiges Gebilde darstellen sollte, in welchem sich diverse Parteien Kompetenzen aneignen müssen, um Kinder und Jugendliche angemessenen vor Cybermobbing zu schützen.
description: + Code Diss LU: hslusa basp + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialpädagogik, 2022 + NL-Code: NLLUHSA202212
Foundations of special relativity : kinematic axioms for Minkowski space-time
Creators: name: Schutz, John W.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
Creators: name: Ramaprasad, Abhinay
name: Burda, Paul-Christian
name: Koussis, Konstantinos
name: Thomas, James A
name: Pietsch, Emma
name: Calvani, Enrica
name: Howell, Steven A
name: MacRae, James I
name: Snijders, Ambrosius P
name: Gilberger, Tim-Wolf
name: Blackman, Michael J
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: subject: Model organisms
subject: Biochemistry & Proteomics
subject: Tumour Biology
subject: Signalling & Oncogenes
subject: Developmental Biology
subject: Human Biology & Physiology
subject: Structural Biology & Biophysics
subject: Cell Biology
subject: Chemical Biology & High Throughput
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Metabolism
subject: Computational & Systems Biology

description: Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim of identifying these effectors, we disrupted the expression of two Plasmodium falciparum perforin-like proteins simultaneously and showed that they have no essential roles during blood stage egress. Proteomic profiling of parasite proteins discharged into the parasitophorous vacuole (PV) just prior to egress detected the presence in the PV of a lecithin:cholesterol acyltransferase (LCAT; PF3D7_0629300). Conditional ablation of LCAT resulted in abnormal egress and a reduced replication rate. Lipidomic profiles of LCAT-null parasites showed drastic changes in several phosphatidylserine and acylphosphatidylglycerol species during egress. We thus show that, in addition to its previously demonstrated role in liver stage merozoite egress, LCAT is required to facilitate efficient egress in asexual blood stage malaria parasites.
Spectrum of fungal pathogens in sputum samples from pulmonary tuberculosis suspected patients at Kotebe primary hospital Addis Ababa Ethiopia
Creators: name: Muluneh, Tamagn
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: Background: pulmonary mycosis is a systemic fungal infection that occurs when fungi cause's diseases of the lungs. Mycobacterium tuberculosis (MTB), the causative agent of pulmonary tuberculosis is one of the major micro organisms that infect this site. Clinical and radiological characteristics of pulmonary mycosis are very similar to that of pulmonary tuberculosis thereby making the disease easily misdiagnosed and mistreated as tuberculosis. Objective: To assess spectrum of fungal etiologies in sputum samples from pulmonary tuberculosis suspected patients at Kotebe primary hospital Addis Ababa, Ethiopia. Methods: A cross sectional descriptive study was conducted at Kotebe primary hospital on 423 sputum samples from presumptive TB patients. Sputum samples were collected aseptically and Presence of pulmonary Tuberculosis was screened by Xpert MTB-Rif/assay. Microscopically fungal elements were screened using 10%KOH. Cultural identification of the different pathogenic fungi was performed using SDA and BHI medium incubated at 25c0 and 37c0 for 4- 6weeks respectively for each sputum samples. Identification was performed by noting; the growth form, and rate of growth, surface and reversed coloration on SDA and BHI agar plates. Yeasts were identified by conventional biochemical tests and assimilation characteristics. Data analysis was carried out using SPSS version 23 software. Results: 423 presumptive TB patients were enrolled in this study of which 50.6% were males. MTB was detected in 7.3% of the patients. Mycotic agents were isolated from 179(42.3%) patients of which 106(59.2%) were males. Co- infection of pulmonary Tuberculosis and a fungal agent was seen in 51.6% of MTB positive subjects. 62.7% of HIV positive patients included showed positive fungal culture. Out of the total isolates in this study, the genuses Aspergillus and Candida were the predominant fungal agents 8.7% and 23.9% respectively. C. cruzi was the predominant fungi in MTB positive subjects. Other fungal etiologies isolated in our study include; Penicillium, S. apiospermum, Fusarium, Mucor, Acremonium, Rhodotorulla, curvularia, Exserohilum species Conclusion; High incidence of fungal isolation (42.3%) was obtained in patients with respiratory symptoms. We recommend for policy makers to conduct further studies and consider the need of fungal screening in these patients
Characterization of the Branching Structure of the Lung from "Macroscopic" Pressure-Volume Measurements
Creators: name: Alencar, A. M.
name: Buldyrev, S. V.
name: Hantos, Z.
name: Majumdar, A.
name: Stanley, H. E.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
Image-based Decision Support Systems: Technical Concepts, Design Knowledge, and Applications for Sustainability
Creators: name: Walk, Jannis
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2023

description: Unstructured data accounts for 80-90% of all data generated, with image data contributing its largest portion. In recent years, the field of computer vision, fueled by deep learning techniques, has made significant advances in exploiting this data to generate value. However, often computer vision models are not sufficient for value creation. In these cases, image-based decision support systems (IB-DSSs), i.e., decision support systems that rely on images and computer vision, can be used to create value by combining human and artificial intelligence. Despite its potential, there is only little work on IB-DSSs so far. In this thesis, we develop technical foundations and design knowledge for IBDSSs and demonstrate the possible positive effect of IB-DSSs on environmental sustainability. The theoretical contributions of this work are based on and evaluated in a series of artifacts in practical use cases: First, we use technical experiments to demonstrate the feasibility of innovative approaches to exploit images for IBDSSs. We show the feasibility of deep-learning-based computer vision and identify future research opportunities based on one of our practical use cases. Building on this, we develop and evaluate a novel approach for combining human and artificial intelligence for value creation from image data. Second, we develop design knowledge that can serve as a blueprint for future IB-DSSs. We perform two design science research studies to formulate generalizable principles for purposeful design — one for IB-DSSs and one for the subclass of image-mining-based decision support systems (IM-DSSs). While IB-DSSs can provide decision support based on single images, IM-DSSs are suitable when large amounts of image data are available and required for decision-making. Third, we demonstrate the viability of applying IBDSSs to enhance environmental sustainability by performing life cycle assessments for two practical use cases — one in which the IB-DSS enables a prolonged product lifetime and one in which the IB-DSS facilitates an improvement of manufacturing processes. We hope this thesis will contribute to expand the use and effectiveness of imagebased decision support systems in practice and will provide directions for future research.
title: An Investigation of efficiency within Cycling
Creators: name: Hopker, James G.
Publisher: name: University of Kent
Year: 2023

description: The effect of training on metabolic efficiency in cycling is an under researched area. Previous studies have not found significant differences in cycling efficiency between trained cyclists and untrained participants which has largely limited further research in this area. However upon closer examination of the literature problematic methods are apparent. The main aim of this thesis was to investigate the effects of training upon metabolic efficiency in cycling. Before this could be done, it was necessary to establish a testing protocol capable of producing reliable data for use in the calculation of metabolic efficiency. This enabled the calculation of an appropriate sample size to have a chance of detecting significant differences between groups of trained and recreational cyclists. Statistically significant differences were consequently found between these two populations. Training studies were therefore needed to establish whether cycling efficiency was affected by training and if so what type. The results of the subsequent training studies showed firstly, that alterations in training volume and intensity did result in changes in the metabolic efficiency of cycling. Secondly, using an intervention study the metabolic efficiency of cycling was specifically increased as a result of the addition of high intensity training. Training volume was shown to have little effect on metabolic efficiency. This thesis is the first to demonstrate that metabolic efficiency is directly influenced by training over a cycling season and is significantly increased as a result of high intensity training.
Qual a influência do estoma na sexualidade? Scoping review
Creators: name: Cabral, Carolina Vieira
name: Veiguinha, Erica Alexandra Vicente
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Diseases
subject: Medicine and Health Sciences
subject: Stomatognathic Diseases

description: Descrever a envolvencia do estoma na vida sexual do casal
Physical characterisation, quantification and biomass determination of bacteria using sedimentation field-flow fractionation
Creators: name: Sharma, Reshmi
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Chromatin information content landscapes inform transcription factor and DNA interactions
Creators: name: D'Oliveira Albanus, R
name: Kyono, Y
name: Hensley, J
name: Varshney, A
name: Orchard, P
name: Kitzman, JO
name: Parker, SCJ
Publisher: name: My University
Year: 2012
Subjects: Binding Sites
Cell Line
Chromatin
DNA
DNA-Binding Proteins
Gene Expression Regulation
Hep G2 Cells
Humans
Nucleosomes
Transcription Factors
Transcription, Genetic

description: Interactions between transcription factors and chromatin are fundamental to genome organization and regulation and, ultimately, cell state. Here, we use information theory to measure signatures of organized chromatin resulting from transcription factor-chromatin interactions encoded in the patterns of the accessible genome, which we term chromatin information enrichment (CIE). We calculate CIE for hundreds of transcription factor motifs across human samples and identify two classes: low and high CIE. The 10–20% of common and tissue-specific high CIE transcription factor motifs, associate with higher protein–DNA residence time, including different binding site subclasses of the same transcription factor, increased nucleosome phasing, specific protein domains, and the genetic control of both chromatin accessibility and gene expression. These results show that variations in the information encoded in chromatin architecture reflect functional biological variation, with implications for cell state dynamics and memory.
Relativistic iron lines in accretion disks: the contribution of higher order images in the strong deflection limit
Creators: name: Aldi, G. F.
name: Bozza, V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The shapes of relativistic iron lines observed in spectra of candidate black holes carry the signatures of the strong gravitational fields in which the accretion disks lie. These lines result from the sum of the contributions of all images of the disk created by gravitational lensing, with the direct and first-order images largely dominating the overall shapes. Higher order images created by photons tightly winding around the black holes are often neglected in the modeling of these lines, since they require a substantially higher computational effort. With the help of the strong deflection limit, we present the most accurate semi-analytical calculation of these higher order contributions to the iron lines for Schwarzschild black holes. We show that two regimes exist depending on the inclination of the disk with respect to the line of sight. Many useful analytical formulae can be also derived in this framework.
description: 23 pages, 13 figures
THE DAMPED OSCILLATIONS OF PASSIVE LIMBS AND THEIR ROLE IN HUMAN LOCOMOTION MECHANICS
Creators: name: MOORHEAD, ALEX PATTEN
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: The mechanics of locomotion classically take into account the work done by muscle force to raise and accelerate the body center of mass and to accelerate limbs with respect to it at each step. This last component, named Internal Work (W_INT), considers only the cost to overcome segment inertia, inherently assuming frictionless joints. Thus, the unavoidable damping opposing segmental oscillation due to anatomical structures within or around the pivoting centers has never been measured so far. The frictional coefficient (b, N.m.s.rad-1) of such a biological rotational damper has been here assessed by sampling the time course of passive oscillation (with respect to the vertical axis) of upper and lower limbs and by analyzing its motion. This experiment (straight pendulum) was performed to assess joint energy dissipation during the swing phase of locomotion. A custom mathematical model, leading to a 2nd Order Non-Linear Ordinary Differential Equation, allowed to infer b values for upper (bUU = 0.39 � 0.08) and lower (bUL = 2.24 � 0.56 N.m.s.rad-1) limbs in 16 healthy males. Phase planes ensured that no muscle activity was involved. In the same population, the passive swing of a lower limb, behaving as an inverted pendulum after a push (body upside-down), was also sampled while loading the leg as to replicate the compressive stress to which the hip joint is exposed during stance phase. Loads ranged from 0 N (mass of leg only) to 118 N. Damper values (b) for the inverted swing of a loaded lower limb increased with the load and ranged from 4.89 � 1.29 to 8.92 � 1.74 N.m.s.rad-1. The influence on locomotion mechanics has been here evaluated. In walking, for instance, each step includes 3 'passively' swinging, unloaded segments (2 upper limbs and the swinging lower limb with joints under tensile stress) and 1 'actively' oscillating, almost fully loaded segment (stance lower limb, joint under compressive stress). The actual experimental results have been combined to provide an estimate of the internal mechanical work due to tissue and joint damping. In walking that is comparable (and should be added) to the estimate obtained by means of a kinematics-based model (Minetti, 1998) and experimental data from the literature of the traditional ?kinematic? W_INT. In the discussion, the potential overestimation and underestimation of those two types of internal work are presented, together with the implications of the presented additional work (and its metabolic equivalent) to the energy balance and efficiency of human locomotion.
Derivation of an Approximate Method for the Analyses of Ribbed Slabs (A Finite Element Approach)
Creators: name: Umeonyiagu, I.E
name: Ogbonna, N.P
Publisher: name: NIPES
Year: 2024

description: This study introduces a new approximate method for analyzing ribbed slabs, named Calibrated Eurocode Results (CER) or Ogbonna-Umeonyiagu's method, based on finite element method (FEM) results. The method was developed by calibrating existing approximate techniques, specifically the ACI coefficient and Eurocode methods, through comparison with FEM results obtained using SAFE 2016. Manual analyses were conducted on ribbed slabs with varying boundary conditions, revealing significant discrepancies between existing approximate methods and FEM results for ribbed slabs. Notably, the Eurocode method showed considerable convergence with FEM results. A statistical regression analysis was performed, yielding calibration factors that improved the accuracy of the Eurocode method, bringing its results within 6% of FEM values, compared to a previous discrepancy of 65%. The newly developed method offers enhanced bending moment coefficients for ribbed slabs, performing better than existing methods and facilitating easier analysis of two-way slabs. A Java program was also created to implement this method, demonstrating its effectiveness and adding to the repertoire of tools available for slab analysis.
L'ESERCIZIO DELL'AZIONE SOCIALE DI RESPONSABILIT� NEL CONCORDATO PREVENTIVO
Creators: name: MARRI, TOMMASO
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: Abstract in italiano L?elaborato tenta di inquadrare nella procedura di concordato preventivo l?istituto dell?esercizio dell?azione sociale di responsabilit� verso gli amministratori, cercando di delineare le sue funzioni all?interno di un?impresa in crisi. Al fine di individuare i possibili utilizzi di suddetto strumento societario, � necessario far chiarezza sulla legittimazione all?esercizio dell?azione sociale durante le varie fasi in cui si articola la procedura di concordato preventivo. In questo studio, quindi, si � cercato di ricostruire una disciplina normativa ? allo stato assente ? che regoli l?esercizio dell?azione sociale di responsabilit� nel concordato preventivo e che correggesse eventuali conflitti di interesse tra soci e amministratori che si avrebbero con la rigida applicazione delle norme di diritto societario ex art. 2393 c.c. e ss. Questo ha consentito di applicare l?istituto dell?esercizio dell?azione sociale di responsabilit� in numerose tipologie di concordato preventivo e di destinare la posta economica ad esso sottesa al miglior soddisfacimento dei creditori sociali. Questo studio si conclude con l?auspicio che, con la ?Riforma della legge concorsuale ancora in cantiere?, il legislatore disciplini compiutamente l?istituto onde evitare incertezze nei singoli casi concreti che si verificano nella prassi giurisprudenziale.
Targeting the tumor microenvironment: Potential strategy for cancer therapeutics
Creators: name: Babar, Quratulain
name: Saeed, Ayesha
name: Tabish, Tanveer A
name: Sarwar, Mohsin
name: Thorat, Nanasaheb
Publisher: name: University of Limerick
Year: 2023

description: Cellular and stromal components including tumor cells, immune cells, mesenchymal cells, cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment (TME). TME plays a crucial role in reprogramming tumor initiation, uncontrolled proliferation, invasion and metastasis as well as response to therapeutic modalities. In recent years targeting the TME has developed as a potential strategy for treatment of cancer because of its life-threatening functions in restricting tumor development and modulating responses to standard-of-care medicines. Cold atmospheric plasma, oncolytic viral therapy, bacterial therapy, nano-vaccine, and repurposed pharmaceuticals with combination therapy, antiangiogenic drugs, and immunotherapies are among the most effective therapies directed by TME that have either been clinically authorized or are currently being studied. This article discusses above-mentioned therapies in light of targeting TME. We also cover problems related to the TME-targeted therapies, as well as future insights and practical uses in this rapidly growing field.
Assessment of Focused Antenatal Care Laboratory Services Statususing Availability, Functional Status and Clients Satisfaction at Public Health Facilities Addis Ababa, Ethiopia
Creators: name: Melese, Daniel
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2015

description: Back ground: Laboratory service is a key component of Focused Antenatal Care (FANC) to identify life threatening conditions of maternal and child health. Limited capacity of health facilities to provide adequate laboratory services remains a major problem for the quality of FANC service delivery. Objective: To assess the status of focused antenatal care laboratory services using availability, functional status and client satisfaction at public health facilities in Addis Ababa, Ethiopia. Methods: Institution based, descriptive cross-sectional study was conducted from April to May 2015. Both quantitative and qualitative designs were used. Four hundred and twenty two study participants interviewed on satisfaction towards FANC laboratory services by using structured questionnaire. A qualitative data was collected by In-depth interview of providers. To assess availability and functionality of the FANC laboratory, observation check list was used. Data were coded and analysed by using SPSS Version 20 software. Logistic regression model was also used to examine the effect of selected variables on clients' satisfaction with laboratory services. P-Value less than 0.05 were taken as statistically significant. Result: Only 5(38.5%) out of 13 visited health facilities reported the availability of all types of basic FANC laboratory investigations. Comparing the availability of individual tests in the study facilities, urine dipstick, urine miscopy and stool examination were available in all institutions. However, only 7 (53.8%) of the facilities reported the availability of Hepatitis B virus screening test. Rapid syphilis/RPR test was found in 10 (76.9%) facilities. All laboratory facilities had at least one or more basic FANC laboratory tests interruption more than a day within the last one year due to shortage of reagent and electric power disruption. Additional analysis of pregnant women's satisfaction toward FANC laboratory service showed, only 56.9 % (240/422) of pregnant mothers were satisfied with FANC laboratory services. Those clients who waited less than one hour to get laboratory results were six times more likely to be satisfied than those who waited more than one hours [AOR = 6.03; CI (2.86-12.67)]. Conclusion: Majority of the health facilities reported incomplete FANC laboratory investigations. Hepatitis B screening test was the lowest available test in the study facilities. Furthermore a slightly higher maternal dissatisfaction toward FANC laboratory service was observed compared with other institutional based study in similar settings
Peakompactons: Peaked compact nonlinear waves
Creators: name: Christov, Ivan C.
name: Kress, Tyler
name: Saxena, Avadh
Publisher: name: arXiv
Year: 2016
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: This article is meant as an accessible introduction to/tutorial on the analytical construction and numerical simulation of a class of non-standard solitary waves termed \emph{peakompactons}. These peaked compactly supported waves arise as solutions to nonlinear evolution equations from a hierarchy of nonlinearly dispersive Korteweg--de Vries-type models. Peakompactons, like the now-well-know compactons and unlike the soliton solutions of the Korteweg--de Vries equation, have finite support, {\it i.e.}, they are of finite wavelength. However, unlike compactons, peakompactons are also peaked, {\it i.e.}, a higher spatial derivative suffers a jump discontinuity at the wave's crest. Here, we construct such solutions exactly by reducing the governing partial differential equation to a nonlinear ordinary differential equation and employing a phase-plane analysis. A simple, but reliable, finite-difference scheme is also designed and tested for the simulation of collisions of peakompactons. In addition to the peakompacton class of solutions, the general physical features of the so-called $K^\#(n,m)$ hierarchy of nonlinearly dispersive Korteweg--de Vries-type models are discussed as well.
description: 27 pages, 8 figures, worldsci template; to appear as an invited contribution to a special issue of the International Journal of Modern Physics B; v2 corrects typos
Single-crystal magnetic studies in transition-metal complexes
Creators: name: Sheahan, Robert Morton
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Application of a new NARC sequence to the enantioselective synthesis of zaragozic acids (squalestatins) and stereoselective intermolecular oxymercurations of trisubstituted allylic ethers
Creators: name: Selajarern, Walailak
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.