cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adherence to surgical hand rubbing directives in a hospital district of Southwest Finland*
Creators: name: Laurikainen, Erkki
name: Rintala, Esa
name: Anne-Mari Kaarto
name: Routamaa, Marianne
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Neuroscience
subject: Medicine

description: Background: The primary objective was to measure the compliance with alcohol-based surgical hand rubbing (SHR) among operation room personnel. The secondary objective was to evaluate the effect of feedback sessions on compliance. Methods: This was a prospective observational before-after intervention study. Between October 2010 and June 2012 the hygiene nurses observed SHR among operation room personnel in the hospital district of Southwest Finland. After feedback sessions a second observation round was conducted in the main operation room of Turku University Hospital. The first observation round comprised 477 observations: 259 (54%) were doctors, 190 (40%) nurses and 28 (5%) other personnel. In the second observation round a total of 210 observations were made. Results: During the first round in 42% of observations the 3 min SHR time recommended by WHO was used. Median times for SHR were 1 min 50 s (range 0 min to 5 min 44 s) for doctors and 3 min 25 s (range 1 min 1 s to 8 min 15 s) for nurses, respectively (p Conclusions: SHR was performed incorrectly in most observations even after feedback. The results stress the importance of more effective education, helping techniques and positive role models for operation room personnel to promote SHR.
Glareola maldivarum Forster 1795
Creators: name: Wilson, John-James
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Charadriiformes
Glareolidae
Glareola
Glareola maldivarum

description: 2149 [3192b]. Oriental Pratincole Glareola maldivarum Forster, 1795
 In 1825, Stanley listed an unsexed specimen as ‘ Glareola Orientalis ’ and ‘Oriental Pratincola [sic]’,ȱbutȱtheȱspeciesȱdoesȱnotȱappearȱinȱRaffles’ȱ(1822)ȱcatalogueȱorȱseemȱtoȱbeȱinȱVigors’ȱ catalogueȱ(Rafflesȱ 1830).ȱ Glareola orientalis ȱ Leachȱ wasȱ describedȱ andȱ figuredȱ(Leachȱ 1821)ȱ inȱ theȱ sameȱ volumeȱ ofȱ theȱ Linneanȱ Societyȱ transactionsȱ asȱ Raffles’ȱ catalogue,ȱ basedȱ onȱ aȱ specimenȱ inȱ Parisȱ broughtȱ fromȱ Javaȱ byȱ M.ȱ Leschenaultȱ (Horsfieldȱ 1821).ȱ Stanley’sȱ G. maldivarum specimen is at NML (accession number D3192b). Oriental Pratincole is principally an uncommon migrant and winter visitor to Sumatra (van Marle & Voous 1988), but has bred in the north of the island (Eaton et al. 2016).
description: Published as part of Wilson, John-James, 2021, Birds from Sumatra given by Sir Stamford Raffles to Lord Stanley: links to names, types and drawings, pp. 39-49 in Bulletin of the British Ornithologists' Club 141 (1) on page 46
Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer
Creators: name: Grønborg, Caroline
name: Vestergaard, Anne
name: Høyer, Morten
name: Söhn, Matthias
name: Pedersen, Erik M
name: Petersen, Jørgen B
name: Agerbæk, Mads
name: Muren, Ludvig P
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering

description: Background. The bladder is a tumour site well suited for adaptive radiotherapy (ART) due to large inter-fractional changes, but it also displays considerable intra-fractional motion. The aim of this study was to assess target coverage with a clinically applied method for plan selection ART and to estimate population-based and patient-specific intra-fractional margins, also relevant for a future re-optimisation strategy.Material and methods. Nine patients treated in a clinical phase II ART trial of daily plan selection for bladder cancer were included. In the library plans, 5 mm isotropic margins were added to account for intra-fractional changes. Pre-treatment and weekly repeat magnetic resonance imaging (MRI) series were acquired in which a full three-dimensional (3D) volume was scanned every second min for 10 min (a total of 366 scans in 61 series). Initially, the bladder clinical target volume (CTV) was delineated in all scans. The t = 0 min scan was then rigidly registered to the planning computed tomography (CT) and plan selections were simulated using the CTV_0 (at t = 0 min). To assess intra-fractional motion, coverage of the CTV_10 (at t = 10 min) was quantified using the applied PTV. Population-based margins were calculated using the van Herk margin recipe while patient-specific margins were calculated using a linear model.Results. For 49% of the cases, the CTV_10 extended more than 5 mm outside the CTV_0. However, in 58 of the 61 cases (97%) CTV_10 was covered by the selected PTV. Population-based margins of 14 mm Sup/Ant, 9 mm Post and 5 mm Inf/Lat were sufficient to cover the bladder. Using patient-specific margins, the overlap between PTV and bowel-cavity was reduced from 137 cm3 with the plan selection strategy to 24 cm3.Conclusion. In this phase II ART trial, 5 mm isotropic margin for intra-fractional motion was sufficient even though considerable intra-fractional motion was observed. In online re-optimised ART, population-based margin can be applied although patient-specific margins are preferable.
Estimating binding free energy of a putative growth factors EGF-VEGF complex - a computational bioanalytical study
Creators: name: Meng-Han Lin
name: C. Allen Chang
name: Fischer, Wolfgang B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Epidermal growth factor (EGF) and homodimeric vascular endothelial growth factor (VEGF) bind to cell surface receptors. They are responsible for cell growth and angiogenesis, respectively. Docking of the individual proteins as monomeric units using ZDOCK 2.3.2 reveals a partial blocking of the receptor binding site of VEGF by EGF. The receptor binding site of EGF is not affected by VEGF. The calculated binding energy is found to be intermediate between the binding energies calculated for Alzheimer’s Aß42 and the barnase/barstar complex.
Expression of collagenase in Flavobacterium psychrophilum isolated from cold-water disease-affected ayu (Plecoglossus altivelis)
Creators: name: Nakayama, Hitoshi
name: Tanaka, Keisuke
name: Teramura, Naoko
name: Hattori, Shunji
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The collagenase activity and the fpcol gene were examined in Flavobacterium psychrophilum isolates from cold-water disease (CWD)-affected ayu, Plecoglossus altivelis. Collagenase expression was closely related to the accumulated mortality of CWD-affected ayu. RT-qPCR and bacterial challenge experiments showed that F. psychrophilum ayu isolate WA-1 expressed the fpcol gene more actively and was more virulent than ayu isolate WA-2. The amago (Oncorhynchus masou) isolate WB-1, which possesses a pseudo-fpcol gene, was not harmful to ayu. Hitherto, the well-studied metalloproteases Fpp1 and Fpp2 have been considered virulence factors. However, the most virulent isolate against ayu (WA-1) showed no Fpp activity because of a deletion mutation or an insertion of a transposon in the fpp genes. The less virulent WA-2 isolate showed only Fpp1 activity. Taken together, these results suggest that collagenolytic activity, but not Fpp activity, is related to the virulence of F. psychrophilum isolates in CWD-affected ayu. Comparative study of Flavobacterium psychrophilum isolates from ayu and amago suggests that the collagenase is one of the pathogenic factors for ayu.
Additional file 1 of Evolution of the consumption trend of proton pump inhibitors in the Lleida Health Region between 2002 and 2015
Creators: name: Torres-Bondia, F.
name: de Batlle, J.
name: Galván, L.
name: Buti, M.
name: Barbé, F.
name: Piñol-Ripoll, G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 1: Table 1. Principal adverse effects of the different subtypes of PPIs. Table 2. Prevalence of long-term consumption of IBPs (cumulative DDD> 180 between 2002 and 2015), according to sex and age groups (%).Table 3. Prevalence of long-term consumption of IBPs (cumulative DDD> 365 between 2002 and 2015), according to sex and age groups (%).
Modeling the risk of spread and establishment for Asian longhorned beetle (Anoplophora glabripennis) in Massachusetts from 2008-2009
Creators: name: Shatz, Andrew J.
name: Rogan, John
name: Sangermano, Florencia
name: Miller, Jennifer
name: Elmes, Arthur
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Land managers responsible for invasive species removal in the USA require tools to prevent the Asian longhorned beetle (Anoplophora glabripennis) (ALB) from decimating the maple-dominant hardwood forests of Massachusetts and New England. Species distribution models (SDMs) and spread models have been applied individually to predict the invasion distribution and rate of spread, but the combination of both models can increase the accuracy of predictions of species spread over time when habitat suitability is heterogeneous across landscapes. First, a SDM was fit to 2008 ALB presence-only locations. Then, a stratified spread model was generated to measure the probability of spread due to natural and human causes. Finally, the SDM and spread models were combined to evaluate the risk of ALB spread in Central Massachusetts in 2008–2009. The SDM predicted many urban locations in Central Massachusetts as having suitable environments for species establishment. The combined model shows the greatest risk of spread and establishment in suitable locations immediately surrounding the epicentre of the ALB outbreak in Northern Worcester with lower risk areas in suitable locations only accessible through long-range dispersal from access to human transportation networks. The risk map achieved an accuracy of 67% using 2009 ALB locations for model validation. This model framework can effectively provide risk managers with valuable information concerning the timing and spatial extent of spread/establishment risk of ALB and potential strategies needed for effective future risk management efforts.
Prognostic factors for the feasibility of chemotherapy and the Geriatric Prognostic Index (GPI) as risk profile for mortality before chemotherapy in the elderly
Creators: name: Aaldriks, Ab A.
name: Maartense, Ed
name: Nortier, Hans J. W. R.
name: Geest, Lydia G. M. Van Der
name: Cessie, Saskia Le
name: Tanis, Bea C.
name: Portielje, Johanneke E. A.
name: Ypma, Paula
name: Giltay, Erik J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Background. Comprehensive geriatric assessment (CGA) is a multidimensional method to detect frailty in elderly patients. Time saving could be accomplished by identifying those individual items that classify elderly cancer patients at risk for feasibility of chemotherapy and for mortality. Material and methods. Patients older than 70 years of age were assessed before the first chemotherapy administration. GA consisted of the Mini Nutritional Assessment (MNA), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Groningen Frailty Indicator (GFI) and Mini Mental State Examination (MMSE). Predictive individual items for feasibility of chemotherapy and mortality were entered in the multivariable logistic regression and Cox-regression models, and a three-item sum scale was constructed: the Geriatric Prognostic Index (GPI). Results. The 494 patients had a median age of 75 years (range 70–92 years). The majority of the patients had malignancies of the digestive tract (41.7%) followed by hematological tumors (22.3%). Three items of the MNA (‘psychological distress or acute disease in the past three months’, ‘neuropsychological problems’ and ‘using > 3 prescript drugs’) independently predicted for feasibility of chemotherapy. Two items of the MNA and one of the GFI (‘declining food intake in past 3 months’, ‘using > 3 prescript drugs’, and ‘dependence in shopping’) independently predicted for mortality. In comparison with patients without any positive item on the three-item GPI, patients with one, two or three positive items had hazard ratios (HRs) of 1.58, 2.32, and 5.58, respectively (all p < 0.001). Conclusions. With only three items of the MNA, feasibility of chemotherapy can be predicted. The three-item GPI may help to identify elderly cancer patients at elevated risk for mortality.
Additional file 1 of Knowledge, attitudes, and practices related to the COVID-19 pandemic among pregnant women in Bangkok, Thailand
Creators: name: Kunno, Jadsada
name: Yubonpunt, Pataraporn
name: Supawattanabodee, Busaba
name: Sumanasrethakul, Chavanant
name: Wiriyasirivaj, Budsaba
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. The full English language version of the questionnaire.
Centropus sinensis subsp. bubutus Horsfield 1821
Creators: name: Wilson, John-James
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Cuculiformes
Cuculidae
Centropus
Centropus sinensis
Centropus sinensis bubutus horsfield, 1821

description: 2150. Greater Coucal Centropus sinensis bubutus Horsfield, 1821
 In 1825, Stanley listed an unsexed specimen simply as ‘ Polophilus ’. Cuculus bubutus (asterisked as Centropus Bubutus ȱHorsfield)ȱwasȱlistedȱbyȱRafflesȱ(1822),ȱaȱnameȱsubsequentlyȱ synonymised under ‘ Centropus Philippensis ȱCuvier’ȱbyȱHorsfieldȱandȱVigorsȱ(Rafflesȱ1830).ȱ This taxon seems to be the most likely to correspond with ‘ Polophilus ’. Lack of a traceable specimen in NML, or a number in Moore’s stock books, suggests it was not part of the 1851 bequest, thereby precluding further determination.
description: Published as part of Wilson, John-James, 2021, Birds from Sumatra given by Sir Stamford Raffles to Lord Stanley: links to names, types and drawings, pp. 39-49 in Bulletin of the British Ornithologists' Club 141 (1) on page 46
Modeling the risk of spread and establishment for Asian Longhorned Beetle (Anoplophora glabripennis) in Massachusetts from 2008-2009
Creators: name: Shatz, Andrew J.
name: Rogan, John
name: Sangermano, Florencia
name: Miller, Jennifer
name: Elmes, Arthur
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences

description: Land managers responsible for invasive species removal in the U.S. require tools to prevent the Asian Longhorned Beetle (Anoplophora glabripennis) (ALB) from decimating the maple-dominant hardwood forests of Massachusetts and New England. Species distribution models (SDMs) and spread models have been applied individually to predict the invasion distribution and rate of spread, but the combination of both models can increase the accuracy of predictions of species spread over time when habitat suitability is heterogeneous across landscapes. First a SDM was fit to 2008 ALB presence-only locations. Then a stratified spread model was generated to measure the probability of spread due to natural and human causes. Finally the SDM and spread models were combined to evaluate the risk of ALB spread in Central Massachusetts in 2008-2009. The SDM predicted many urban locations in Central Massachusetts as having suitable environments for species establishment. The combined model shows the greatest risk of spread and establishment in suitable locations immediately surrounding the epicenter of the ALB outbreak in northern Worcester with lower risk areas in suitable locations only accessible through long-range dispersal from access to human transportation networks. The risk map achieved an accuracy of 67% using 2009 ALB locations for model validation. This model framework can effectively provide risk managers with valuable information concerning the timing and spatial extent of spread/establishment risk of ALB and potential strategies needed for effective future risk management efforts.
Additional file 1 of Talking about chronic pain in family settings: a glimpse of older persons’ everyday realities
Creators: name: Merminod, Gilles
name: Weber, Orest
name: Semlali, Imane
name: Terrier, Anamaria
name: Decosterd, Isabelle
name: Rubli Truchard, Eve
name: Singy, Pascal
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Main extracted themes.
Topological photonic alloy
Creators: name: Qu, Tiantao
name: Wang, Mudi
name: Cheng, Xiaoyu
name: Cui, Xiaohan
name: Zhang, Ruo-Yang
name: Zhang, Zhao-Qing
name: Zhang, Lei
name: Chen, Jun
name: Chan, C. T.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present the new concept of photonic alloy as a non-periodic topological material. By mixing non-magnetized and magnetized rods in a non-periodic 2D photonic crystal configuration, we realized photonic alloys in the microwave regime. Our experimental findings reveal that the photonic alloy sustains non-reciprocal chiral edge states (CESs) even at very low concentration of magnetized rods. The non-trivial topology and the associated edge states of these non-periodic systems can be characterized by the winding of the reflection phase. Our results indicate that the threshold concentrations for the investigated system within the first non-trivial band gap to exhibit topological behavior approach zero in the thermodynamic limit for substitutional alloys, while the threshold remains non-zero for interstitial alloys. At low concentration, the system exhibits an inhomogeneous structure characterized by isolated patches of non-percolating magnetic domains that are spaced far apart within a topologically trivial photonic crystal. Surprisingly, the system manifests CESs despite a local breakdown of time-reversal symmetry rather than a global one. Photonic alloys represent a new category of disordered topological materials, offering exciting opportunities for exploring topological materials with adjustable gaps.
description: 6 pages, 4 figures
Onychoprion anaethetus
Creators: name: Wilson, John-James
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Charadriiformes
Laridae
Onychoprion
Onychoprion anaethetus

description: 2151. Bridled Tern Onychoprion anaethetus (Scopoli, 1786)
 In 1825, Stanley listed an unsexed specimen as ‘Panyan Tern’ and ‘ Sterna Panay [sic]’. Listed as ‘ Sterna panayensis ? Gmel. [sic]’ȱ byȱ Rafflesȱ (1822),ȱ butȱ theȱ descriptionȱ clearlyȱ involvesȱ Bridled Tern (= Onychoprion anaethetus) which is resident in western Sumatra (van Marle & Voous 1988). The species was listed as ‘ Sterna Panayensis Gmel. [sic]’ȱbyȱVigorsȱ(Rafflesȱ 1830). Lack of a traceable specimen in NML, or a number in Moore’s stock books, suggests it was not part of the 1851 bequest.
description: Published as part of Wilson, John-James, 2021, Birds from Sumatra given by Sir Stamford Raffles to Lord Stanley: links to names, types and drawings, pp. 39-49 in Bulletin of the British Ornithologists' Club 141 (1) on page 46
Rhode Island Modified UDL Educator Checklist – Version 1.3 (2019)
Creators: name: Dalton, Elizabeth
name: Abruzinni, Deborah
Publisher: name: University of Cape Town
Year: 2024
Subjects: classificationCode: 390407
subject: Inclusive education

description: This resource is designed as a checklist for educators to analyse a lesson or module in terms of Universal Design for Learning (UDL) principles. Use this checklist to identify what components are present (Y), not present (N), or not sure (?). The checklist is also appropriate for planning lessons according to UDL principles. This resource is a modification of the original CAST Educator Checklist made by RI-UDL Workgroup @ Rhode Island College, Providence, RI & University of Rhode Island, Kingston, RI (Version 1.1, 2009).
Additional file 3 of Mycobacterium bovis and M. caprae in Bulgaria: insight into transmission and phylogeography gained through whole-genome sequencing
Creators: name: Valcheva, Violeta
name: Perea, Claudia
name: Savova-Lalkovska, Tanya
name: Dimitrova, Albena
name: Radulski, Lukasz
name: Mokrousov, Igor
name: Marinov, Krustyu
name: Najdenski, Hristo
name: Bonovska, Magdalena
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3: Figure S1. Phylogenetic tree of Bulgarian isolates with world isolates. Based on classification by Loiseau et al., 2020 [26].
The involvement of the Toll-like receptor signaling and Nrf2-Keap1 pathways in the in vitro regulation of IL-8 and HMOX1 for skin sensitization
Creators: name: Loveren, Henk Van
name: Veen, Jochem W. Van Der
name: Ruthmila F. Paskel
name: Smits, Noortje A. M.
name: Hodemaekers, Henny
name: Ezendam, Janine
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Computational Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Biophysics

description: In vitro gene profiling studies have associated the molecular pathways of Nrf2-Keap1 and Toll-like receptor (TLR) signaling with skin sensitization. In this study, the role of these pathways in the regulation of protein biomarkers for skin sensitization was further elucidated using transient gene knock-down of key components of the signaling cascades in HaCaT cells after exposure to dinitrochlorobenzene (DNCB). The effect of targeting these pathways was established through evaluation of heme oxygenase1 (HMOX1) and interleukin (IL)-8 production. These experiments showed that Nrf2 is not involved in regulating HMOX1 after exposure to DNCB, but that activation of TLR signaling moderates the expression of HMOX1. The regulation of IL-8 depended on Nrf2, but also on the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF) adaptor protein in TLR signaling. This study provides new insights into the regulation of HMOX1 and IL-8, but the exact regulating mechanisms remain to be further elucidated.
Engineering an artificial catch bond using mechanical anisotropy
Creators: name: Liu, Zhaowei
name: Liu, Haipei
name: Vera, Andres
name: Yang, Byeongseon
name: Tinnefeld, Philip
name: Nash, Michael
Publisher: name: Zenodo
Year: 2024

description: Source data for main text and supplementary figures for the paper: 

"Engineering an artificial catch bond using mechanical anisotropy"
Cubosome particles of a novel Guerbet branched chain glycolipid
Creators: name: Salim, Malinda
name: N. Idayu Zahid
name: Liew, Chia Yen
name: Rauzah Hashim
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Cubic liquid crystalline nanoparticles (cubosomes) of bicontinuous nature with internal networks of water channels have received great interests in nanomedicine applications, particularly as potential vehicle for loading and release of therapeutic agents. These nanoparticles have been most commonly produced using monoolein and phytantriol. In this study, we explore the use of a Guerbet branched chain glycolipid, namely 2-hexyl-decyl-β-D glucopyranoside (β-Glc−OC10C6), as a new and alternative material for cubosomes production. The fully hydrated glycolipid assumes a reverse bicontinuous cubic liquid crystal phase of an Ia3d space group with lattice parameter of ca. 74 Å, as confirmed using a small-angle X-ray scattering. Dynamic light scattering and a conventional transmission electron microscopy were used to investigate the average size and morphology of the cubosomes. The effectiveness of Poloxamer 407 (stabiliser typically used in other cubosome systems against aggregations and particle coalescence) in providing steric stabilisation of the glycolipid cubosomes was assessed through visual assessment.
Additional file 2 of Association and mediation analyses among multiple metals exposure, plasma folate, and community-based impaired estimated glomerular filtration rate in central Taiwan
Creators: name: Chung, Mu-Chi
name: Hsu, Hui-Tsung
name: Mao, Yan-Chiao
name: Wu, Chin-Ching
name: Ho, Chih-Te
name: Liu, Chiu-Shong
name: Chung, Chi-Jung
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Additional file 2: Supplementary Table 1. Detection frequency and distributions of 5 heavy metals in blood.
Additional file 1 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Creators: name: Kivisäkk, Pia
name: Carlyle, Becky C.
name: Sweeney, Thadryan
name: Quinn, James P.
name: Ramirez, Christopher E.
name: Trombetta, Bianca A.
name: Mendes, Muriel
name: Brock, Mary
name: Rubel, Carrie
name: Czerkowicz, Julie
name: Graham, Danielle
name: Arnold, Steven E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Figure 1. Western blots of PSD-95 capture and detection antibodies. Homogenized brain samples were prepared by sonicating 100 mg of prefrontal cortex tissue from autopsy materials from two elderly subjects without cognitive complaints (Normal) and two subjects with Alzheimer’s disease (AD-Dem). Proteins were separated using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), transferred to a nitrocellulose membrane, and stained with the PSD-95 capture (anti-PSD-95 mouse IgG) or detection (anti-PSD-95 rabbit IgG) antibodies overnight at 4°C followed by fluorescently-conjugated secondary antibodies for 1h at RT in the dark. Imaging was performed using a Licor ODYSSEY CLx (LI-COR Biosciences, Lincoln, NE). A pre-stained precision plus protein dual color standards molecular weight ladder (10-250kDa; Bio-Rad, Hercules, CA) was used to estimate the molecular weight of the proteins analyzed. The western blots were performed in triplicate and repeated in two separate experiments to confirm that the results were reproducible.
Expression of collagenase in Flavobacterium psychrophilum isolated from cold-water disease-affected ayu (Plecoglossus altivelis)
Creators: name: Nakayama, Hitoshi
name: Tanaka, Keisuke
name: Teramura, Naoko
name: Hattori, Shunji
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology

description: The collagenase activity and the fpcol gene were examined in Flavobacterium psychrophilum isolates from cold-water disease (CWD)-affected ayu, Plecoglossus altivelis. Collagenase expression was closely related to the accumulated mortality of CWD-affected ayu. RT-qPCR and bacterial challenge experiments showed that F. psychrophilum ayu isolate WA-1 expressed the fpcol gene more actively and was more virulent than ayu isolate WA-2. The amago (Oncorhynchus masou) isolate WB-1, which possesses a pseudo-fpcol gene, was not harmful to ayu. Hitherto, the well-studied metalloproteases Fpp1 and Fpp2 have been considered virulence factors. However, the most virulent isolate against ayu (WA-1) showed no Fpp activity because of a deletion mutation or an insertion of a transposon in the fpp genes. The less virulent WA-2 isolate showed only Fpp1 activity. Taken together, these results suggest that collagenolytic activity, but not Fpp activity, is related to the virulence of F. psychrophilum isolates in CWD-affected ayu.
Cubosome particles of a novel Guerbet branched chain glycolipid
Creators: name: Salim, Malinda
name: N. Idayu Zahid
name: Liew, Chia Yen
name: Rauzah Hashim
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Cubic liquid crystalline nanoparticles (cubosomes) of bicontinuous nature with internal networks of water channels have received great interests in nanomedicine applications, particularly as potential vehicle for loading and release of therapeutic agents. These nanoparticles have been most commonly produced using monoolein and phytantriol. In this study, we explore the use of a Guerbet branched chain glycolipid, namely 2-hexyl-decyl-β-D glucopyranoside (β-Glc−OC10C6), as a new and alternative material for cubosomes production. The fully hydrated glycolipid assumes a reverse bicontinuous cubic liquid crystal phase of an Ia3d space group with lattice parameter of ca. 74 Å, as confirmed using a small-angle X-ray scattering. Dynamic light scattering and a conventional transmission electron microscopy were used to investigate the average size and morphology of the cubosomes. The effectiveness of Poloxamer 407 (stabiliser typically used in other cubosome systems against aggregations and particle coalescence) in providing steric stabilisation of the glycolipid cubosomes was assessed through visual assessment.
Doppler assessment of uterine blood flow in pre-eclampsia: a review
Creators: name: Kane, Stefan C.
name: Dennis, Alicia T.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Plasma Physics
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Medicine

description: Doppler ultrasonography plays an ever-increasing role in obstetric imaging. Although commonly purported to assess blood flow, most studies in this area report purely on velocimetric parameters, rather than true volumetric flow. This review article highlights the physiological importance of this distinction, and reports on a literature review of uterine artery Doppler interrogation in the context of pre-eclampsia, which identified only four original research papers that attempted to assess blood flow. Attention is needed for true volumetric flow assessment in pre-eclampsia research, which may permit a more complete conceptualisation of the pathogenesis and haemodynamic consequences of this condition.
Additional file 2 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Creators: name: Kivisäkk, Pia
name: Carlyle, Becky C.
name: Sweeney, Thadryan
name: Quinn, James P.
name: Ramirez, Christopher E.
name: Trombetta, Bianca A.
name: Mendes, Muriel
name: Brock, Mary
name: Rubel, Carrie
name: Czerkowicz, Julie
name: Graham, Danielle
name: Arnold, Steven E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Supplementary Figure 2. Amyloid ß42/40 (Aß42/40) ratio in subjects with Alzheimer’s Disease (AD) and controls in (A) Cohort I measured using Quanterix Simoa Neurology 4-plex E (N4PE) assay and (B) Cohort II measured using Euroimmun Beta-Amyloid (1-40) and (1-42) ELISA assays. The cutoff for AD pathology was set at an Aß42/40 ratio of 0.065 in Cohort I and 0.080 in Cohort II (red dashed line). Abbreviations: HC=Healthy Controls, AD=Alzheimer’s Disease, MCI=Mild Cognitive Impairment, DEM=dementia, FTD=Frontotemporal Dementia, LBD/Park=Lewy Body Dementia/Parkinson’s Disease, MND=Motor Neuron Diseases, NOS=Not Otherwise Specified, INFL=Immune/Demyelinating Diseases, IIH=Idiopathic Intracranial Hypertension, NCtrl Other=Other Neurological Conditions, AD_Asympt=Cognitively unimpaired subjects with positive CSF AD biomarkers, NeuroDegen=Neurodegenerative Diseases.
On Analysis of Longitudinal Clinical Trials with Missing Data Using Reference-Based Imputation
Creators: name: G. Frank Liu
name: Pang, Lei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine

description: Reference-based imputation (RBI) methods have been proposed as sensitivity analyses for longitudinal clinical trials with missing data. The RBI methods multiply impute the missing data in treatment group based on an imputation model built from the reference (control) group data to yield a conservative treatment effect estimate compared to multiple imputation (MI) under missing at random (MAR). However, the RBI analysis based on regular MI approach can be overly conservative because it not only applies discount to treatment effect estimate but also posts penalty on the variance estimate. In this paper, we investigate the statistical properties of RBI methods, and propose approaches to get accurate variance estimates using both frequentist and Bayesian methods for the RBI analysis. Results from simulation studies and applications to longitudinal clinical trial datasets are presented.
Oscillations of Majorana neutrinos in supernova and CP violation
Creators: name: Popov, A.
name: Studenikin, A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Leptonic CP violation is one of the most important topics in neutrino physics. CP violation in the neutrino sector is strongly related to the nature of neutrinos: whether they are Dirac or Majorana particles. In \cite{Popov:2021icg} we have shown that for Majorana neutrinos appearance of nonzero Majorana CP-violating phases combined with strong magnetic field during supernova core-collapse can induce new resonances in neutrino oscillations, for example in $ν_e \to \barν_τ$ channel. In this paper we further study new resonances in Majorana neutrino oscillations, in particular energy dependence of amplitudes of resonant oscillations. Our findings suggest a potential astrophysical setup for studying the nature of neutrino masses and leptonic CP violation and may be important for future neutrino experiments, such as JUNO, Hyper-Kamiokande and DUNE.
description: arXiv admin note: substantial text overlap with arXiv:2302.05908
Early School Leaving in Spain: a longitudinal analysis by gender
Creators: name: Martín-González, Martín
name: González-Betancor, Sara M.
name: Pérez-Esparrells, Carmen
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Economics (econ.GN)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: Spain is one of the eight EU-27 countries that failed to reduce early school leaving (ESL) below 10% in 2020, and now faces the challenge of achieving a rate below 9% by 2030. The determinants of this phenomenon are usually studied using cross-sectional data at the micro-level and without differentiation by gender. In this study, we analyse it for the first time for Spain using panel data (between 2002-2020), taking into account the high regional inequalities at the macroeconomic level and the masculinisation of the phenomenon. The results show a positive relationship between ESL and socioeconomic variables such as the adolescent fertility rate, immigration, unemployment or the weight of the industrial and construction sectors in the regional economy, with significant gender differences that invite us to discuss educational policies. Surprisingly, youth unemployment has only small but significant impact on female ESL.
description: 35 pages, 3 tables, 8 figures
Impact of educational interventions in therapy programs for people with schizophrenia (PwS): A systematic review
Creators: name: Cahaya, Noor
name: Kristina, Susi Ari
name: Widayanti, Anna Wahyuni
name: GREEN, JAMES
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Not only antipsychotics, but also additional interventions, such as education, are essential in the treatment of individuals with schizophrenia. This study aims to assess the impact of educational interventions within therapy programs for people with schizophrenia (PwS). Eligible studies were identified through searches in two electronic databases, PubMed and Science Direct, as well as a manual search. The search encompassed specific terms, namely ("people with schizophrenia" OR "patients with schizophrenia") AND ("education" OR "knowledge") AND ("medication adherence" OR "medication compliance" OR "medication persistence"). The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were employed for this systematic review. A team of three reviewers conducted article screening for inclusion and data extraction. The selected studies' quality was assessed using the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials. Out of 666 studies, only seven met the criteria for a full review, spanning the period from 2012 to 2022. Educational interventions for patients can take the form of either a component within a therapy program or a comprehensive psychoeducational program that targets the patient, their family, or caregiver. These interventions are delivered by various healthcare professionals, including therapists, researchers, psychiatrists, and pharmacists. The duration of each intervention varies, ranging from three to eight sessions, with each session lasting approximately 45 to 120 minutes. Educational interventions yield inconsistent outcomes in terms of improving adherence, quality of life, stigma, and insight. However, they demonstrate positive outcomes in cognitive and social functioning as well as knowledge scores. Limitations that influence study outcomes encompass variations in patient characteristics, methodologies, and measurement instruments. In the future, clinicians can utilize these findings as a reference for tailoring educational interventions based on individual patient needs and characteristics within clinical settings
Molecular dynamics study of biodegradation of azo dyes via their interactions with AzrC azoreductase
Creators: name: Haghshenas, Hamed
name: Kay, Maryam
name: Dehghanian, Fariba
name: Tavakol, Hossein
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Azo dyes are one of the most important class of dyes, which have been widely used in industries. Because of the environmental pollution of azo dyes, many studies have been performed to study their biodegradation using bacterial systems. In present work, the AzrC of mesophilic gram-positive Bacillus sp. B29 has been considered to study its interaction with five common azo dyes (orange G, acid red 88, Sudan I, orange I, and methyl red). The molecular dynamics simulations have been employed to study the interaction between AzrC and azo dyes. The trajectory was confirmed using root mean square deviation and the root mean square fluctuation analyses. Then, the hydrogen bond and alanine scanning analyses were performed to reveal active site residues. Phe105 (A), Phe125 (B), Phe172 (B), and Pro132 (B) have been found as the most important hydrophobic residues whereas Asn104 (A), Tyr127 (B), and Asn187 (A) have key role in making hydrogen bond. The results of molecular mechanics Poisson–Boltzmann surface area and molecular mechanics generalized Born surface area calculations proved that the hydrophobic azo dyes like Acid red 88 binds more tightly to the AzrC protein. The calculated data suggested MR A 121 (B) I as a potential candidate for improving the AzrC–MR interactions.
Molecular dynamics study of biodegradation of azo dyes via their interactions with AzrC azoreductase
Creators: name: Haghshenas, Hamed
name: Kay, Maryam
name: Dehghanian, Fariba
name: Tavakol, Hossein
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Azo dyes are one of the most important class of dyes, which have been widely used in industries. Because of the environmental pollution of azo dyes, many studies have been performed to study their biodegradation using bacterial systems. In present work, the AzrC of mesophilic gram-positive Bacillus sp. B29 has been considered to study its interaction with five common azo dyes (orange G, acid red 88, Sudan I, orange I, and methyl red). The molecular dynamics simulations have been employed to study the interaction between AzrC and azo dyes. The trajectory was confirmed using root mean square deviation and the root mean square fluctuation analyses. Then, the hydrogen bond and alanine scanning analyses were performed to reveal active site residues. Phe105 (A), Phe125 (B), Phe172 (B), and Pro132 (B) have been found as the most important hydrophobic residues whereas Asn104 (A), Tyr127 (B), and Asn187 (A) have key role in making hydrogen bond. The results of molecular mechanics Poisson–Boltzmann surface area and molecular mechanics generalized Born surface area calculations proved that the hydrophobic azo dyes like Acid red 88 binds more tightly to the AzrC protein. The calculated data suggested MR A 121 (B) I as a potential candidate for improving the AzrC–MR interactions.
Harpocrates Second Issue of the Newsletter
Creators: name: HARPOCRATES Consortium
Publisher: name: Zenodo
Year: 2023

description: This is the second newsletter of the HARPOCRATES project.It provides updates on technical progress, key research achievements, and highlights activities such as publications, events, and collaborations.The newsletter focuses on advancing privacy-preserving technologies, particularly in the areas of Functional Encryption, Hybrid Homomorphic Encryption, and secure machine learning.
Association of platelet activation markers with cancer-associated venous thromboembolism
Creators: name: Riedl, Julia
name: Kaider, Alexandra
name: Marosi, Christine
name: Zielinski, Christoph
name: Panzer, Simon
name: Pabinger, Ingrid
name: Ay, Cihan
name: Hell, Lena
name: Koder, Silvia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Medicine

description: Venous thromboembolism (VTE) is a frequent complication in cancer patients. Platelet activation is thought to be involved in cancer-associated VTE. Here, we determined the association between evolving markers of platelet activation (soluble P-selectin [sP-selectin], soluble CD40 ligand [sCD40L], thrombospondin-1 [TSP-1] and platelet factor-4 [PF-4]) and the development of cancer-associated VTE. A nested matched case–control study was applied within a cohort of 1779 patients with different types of cancer that had been included in the Vienna Cancer and Thrombosis Study (CATS), a prospective, observational study on patients with newly diagnosed or progressive cancer after remission. Primary endpoint is symptomatic VTE during a maximum follow-up of 2 years. Cases (patients who developed VTE during follow-up) were matched in a 1:2 ratio to controls without VTE during follow-up with respect to tumor type, stage and time of observation in the study. In total, 131 VTE cases were compared to 262 controls. In logistic regression analysis, only sP-selectin was associated with risk of VTE. The odds ratios (OR) per double increase of sP-selectin, sCD40L, TSP-1 and PF-4 were 1.66 (95% confidence interval: 1.17–2.35, p = 0.005), 1.04 (0.89–1.21, p = 0.635), 1.09 (0.90–1.32, p = 0.360) and 1.03 (0.87–1.21, p = 0.737), respectively. In conclusion, sP-selectin, but not sCD40L, TSP-1 or PF-4 were associated with risk of VTE in cancer patients in this nested case–control study.