cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series
Creators: name: Maurer, Marcus
name: Magerl, Markus
name: Aygören-Pürsün, Emel
name: Bork, Konrad
name: Farkas, Henriette
name: Longhurst, Hilary
name: Kiani‑Alikhan, Sorena
name: Bouillet, Laurence
name: Boccon-Gibod, Isabelle
name: Cancian, Mauro
name: Zanichelli, Andrea
name: Launay, David
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Angioedema
subject: hereditary
subject: Prophylaxis
subject: Attenuated androgens
subject: Danazol
subject: Oxandrolone
subject: Case series
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuated androgens has not been assessed in large, randomized, placebo-controlled trials and can be associated with frequent, and sometimes severe, side effects. As better tolerated targeted therapies become available, attenuated androgen withdrawal is increasingly considered by physicians and their patients with HAE. Attenuated androgens withdrawal has not been systematically studied in HAE, although examination of other disorders indicates that attenuated androgen withdrawal may result in mood disturbances and flu-like symptoms. Standardized protocols for attenuated androgen discontinuation that continue to provide control of attacks while limiting potential attenuated androgen withdrawal symptoms are not established as the outcomes of different withdrawal strategies have not been compared. We aim to describe the challenges of attenuated androgen discontinuation in patients with HAE and how these may continue into the post-androgen period. Case presentation: We present a retrospective case series of 10 patients with confirmed type I HAE who have discontinued prophylactic treatment with attenuated androgens. The most common reason for attenuated androgen discontinuation was side effects. Attenuated androgens were either immediately withdrawn, tapered and/or overlapped with another treatment. The major challenge of discontinuation was the management of an increased frequency and severity of HAE attacks in some patients. Conclusions: Healthcare teams need to undertake careful planning and monitoring after attenuated androgens discontinuation, and modify treatment strategies if HAE control is destabilized with an increased number of attacks. Discontinuation of attenuated androgens is definitively an option in an evolving HAE treatment landscape, and outcomes can be favourable with additional patient support and education.
Acidification is an essential process of cold atmospheric plasma and promotes the anti-cancer effect on malignant melanoma cells
Creators: name: Schneider, Christin
name: Gebhardt, Lisa
name: Arndt, Stephanie
name: Karrer, Sigrid
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: cold atmospheric plasma; malignant melanoma; calcium signaling; acidification; nitration
subject: 610 Medizin

description: Background: Cold atmospheric plasma (CAP) is ionized gas near room temperature. The anti-cancer effects of CAP were confirmed for several cancer types and were attributed to CAP-induced reactive species. However, the mode of action of CAP is still not well understood. (2) Methods: Changes in cytoplasmic Ca2+ level after CAP treatment of malignant melanoma cells were analyzed via the intracellular Ca2+ indicator fura-2 AM. CAP-produced reactive species were determined by fluorescence spectroscopic and protein nitration by Western Blot analysis. (3) Results: CAP caused a strong acidification of water and solutions that were buffered with the so-called Good buffers, while phosphate-buffered solutions with higher buffer capacity showed minor pH reductions. The CAP-induced Ca2+ influx in melanoma cells was stronger in acidic pH than in physiological conditions. NO formation that is induced by CAP was dose- and pH-dependent and CAP-treated solutions only caused protein nitration in cells under acidic conditions. (4) Conclusions: We describe the impact of CAP-induced acidification on the anti-cancer effects of CAP. A synergistic effect of CAP-induced ROS, RNS, and acidic conditions affected the intracellular Ca2+ level of melanoma cells. As the microenvironment of tumors is often acidic, further acidification might be one reason for the specific anti-cancer effects of CAP.
An Efficient Two-Stage Sparse Representation Method
Creators: name: Peng, Chengyu
name: Cheng, Hong
name: Ko, Manchor
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences
subject: G.1.6; I.4.10

description: There are a large number of methods for solving under-determined linear inverse problem. Many of them have very high time complexity for large datasets. We propose a new method called Two-Stage Sparse Representation (TSSR) to tackle this problem. We decompose the representing space of signals into two parts, the measurement dictionary and the sparsifying basis. The dictionary is designed to approximate a sub-Gaussian distribution to exploit its concentration property. We apply sparse coding to the signals on the dictionary in the first stage, and obtain the training and testing coefficients respectively. Then we design the basis to approach an identity matrix in the second stage, to acquire the Restricted Isometry Property (RIP) and universality property. The testing coefficients are encoded over the basis and the final representing coefficients are obtained. We verify that the projection of testing coefficients onto the basis is a good approximation of the signal onto the representing space. Since the projection is conducted on a much sparser space, the runtime is greatly reduced. For concrete realization, we provide an instance for the proposed TSSR. Experiments on four biometrics databases show that TSSR is effective and efficient, comparing with several classical methods for solving linear inverse problem.
description: 21 pages, 2 figures, 4 tables
TranSentCut ๏ญ transformer based Thai sentence segmentation
Creators: name: Sumeth Yuenyong
name: Virach Sornlertlamvanich
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: sentence segmentation
natural language processing
neural network
transformer model

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 852-860
Spatio-temporal variation in fish diversity and assemblage patternsin the Lower Tapee River, Southern Thailand
Creators: name: Wattana Noonin
name: Pisit Phomikong
name: Achara Jutagate
name: Tuantong Jutagate
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: Tapee River
fishes
Shannonโ"Weaver Hโ-index
W-statistic
assemblages

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 861-868
TMEM16F/Anoctamin 6 in Ferroptotic Cell Death
Creators: name: Ousingsawat, Jiraporn
name: Schreiber, Rainer
name: Kunzelmann, Karl
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: Anoctamin 6; TMEM16F; apoptosis; ferroptosis; Ca2+ signaling; cell death
subject: 570 Biowissenschaften, Biologie

description: Ca2+ activated Cl− channels (TMEM16A; ANO1) support cell proliferation and cancer growth. Expression of TMEM16A is strongly enhanced in different types of malignomas. In contrast, TMEM16F (ANO6) operates as a Ca2+ activated chloride/nonselective ion channel and scrambles membrane phospholipids to expose phosphatidylserine at the cell surface. Both phospholipid scrambling and cell swelling induced through activation of nonselective ion currents appear to destabilize the plasma membrane thereby causing cell death. There is growing evidence that activation of TMEM16F contributes to various forms of regulated cell death. In the present study, we demonstrate that ferroptotic cell death, occurring during peroxidation of plasma membrane phospholipids activates TMEM16F. Ferroptosis was induced by erastin, an inhibitor of the cystine-glutamate antiporter and RSL3, an inhibitor of glutathione peroxidase 4 (GPX4). Cell death was largely reduced in the intestinal epithelium, and in peritoneal macrophages isolated from mice with tissue-specific knockout of TMEM16F. We show that TMEM16F is activated during erastin and RSL3-induced ferroptosis. In contrast, inhibition of ferroptosis by ferrostatin-1 and by inhibitors of TMEM16F block TMEM16F currents and inhibit cell death. We conclude that activation of TMEM16F is a crucial component during ferroptotic cell death, a finding that may be useful to induce cell death in cancer cells.
Development of multiplex methylation-specific PCRfor detecting methylated/un-methylated PTEN promoterin breast cancer patients using a single closed tube
Creators: name: Primariadewi Rustamadji
name: Azamris
name: Nunung Ainur Rahmah
name: Putri, Elsa Septiani
name: Wati, Rosita
name: Shifani, Nadya
name: Yeremiah Rubin Camin
name: Endry Nugroho Prasetyo
name: Kartini Eriani
name: Wiyarta, Elvan
name: Desriani
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: PTEN
Methylation
recombinant plasmid
breast cancer
detection
diagnosis
multiple

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 869-875
Inclusion body myositis and associated diseases: an argument for shared immune pathologies
Creators: name: Nelke, Christopher
name: Kleefeld, Felix
name: Preusse, Corinna
name: Ruck, Tobias
name: Stenzel, Werner
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Inclusion body myositis
subject: Pathophysiology
subject: CD8+T cells
subject: Immune senescence
subject: Cellular senescence
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different sub-entities, with the exception perhaps being the presence or absence of the anti-cN-1A-antibody. In contrast to other IIM, IBM is characterized by a chronic and progressive disease course. Here, we discuss the pathophysiological framework of IBM and highlight the seemingly prototypical situations where IBM occurs in the context of other diseases. In this context, understanding common immune pathways might provide insight into the pathogenesis of IBM. Indeed, IBM is associated with a distinct set of conditions, such as human immunodeficiency virus (HIV) or hepatitis C-two conditions associated with premature immune cell exhaustion. Further, the pathomorphology of IBM is reminiscent of other muscle diseases, notably HIV-associated myositis or granulomatous myositis. Distinct immune pathways are likely to drive these commonalities and senescence of the CD8(+) T cell compartment is discussed as a possible mechanism of pathogenesis. Future effort directed at understanding the co-occurrence of IBM and associated diseases could prove valuable to better understand the enigmatic IBM pathophysiology.
DNA-catalyzed Henry Reaction in Pure Water and the Striking Influence of Organic Buffer Systems
Creators: name: Häring, Marleen
name: Pérez-Madrigal, Maria M.
name: Kühbeck, Dennis
name: Pettignano, Asja
name: Quignard, Françoise
name: Diaz Diaz, David
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: DNA; C–C bond formation; nitroaldol reaction; Henry reaction; buffer solutions
subject: 540 Chemie

description: In this manuscript we report a critical evaluation of the ability of natural DNA to mediate the nitroaldol (Henry) reaction at physiological temperature in pure water. Under these conditions, no background reaction took place (i.e., control experiment without DNA). Both heteroaromatic aldehydes (e.g., 2-pyridinecarboxaldehyde) and aromatic aldehydes bearing strong or moderate electron-withdrawing groups reacted satisfactorily with nitromethane obeying first order kinetics and affording the corresponding β-nitroalcohols in good yields within 24 h. In contrast, aliphatic aldehydes and aromatic aldehydes having electron-donating groups either did not react or were poorly converted. Moreover, we discovered that a number of metal-free organic buffers efficiently promote the Henry reaction when they were used as reaction media without adding external catalysts. This constitutes an important observation because the influence of organic buffers in chemical processes has been traditionally underestimated.
Random transverse-field Ising chain with long-range interactions
Creators: name: Juhász, Róbert
name: Kovács, István A.
name: Iglói, Ferenc
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the low-energy properties of the long-range random transverse-field Ising chain with ferromagnetic interactions decaying as a power alpha of the distance. Using variants of the strong-disorder renormalization group method, the critical behavior is found to be controlled by a strong-disorder fixed point with a finite dynamical exponent z_c=alpha. Approaching the critical point, the correlation length diverges exponentially. In the critical point, the magnetization shows an alpha-independent logarithmic finite-size scaling and the entanglement entropy satisfies the area law. These observations are argued to hold for other systems with long-range interactions, even in higher dimensions.
description: 6 pages, 4 figures
Parametric optimization in WEDM machining processfor OHNS steel and its experimental validation
Creators: name: Sambhaji Venkatrao Sagare
name: Pawar, Shyam Sunder
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: WEDM
OHNS steel
MRR
SR
Taguchi
ANOVA

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 876-883
Model independent determination of the muonic hydrogen Lamb shift and proton radius
Creators: name: Peset, Clara
name: Pineda, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We obtain a model independent expression for the muonic hydrogen Lamb shift. This expression includes the leading logarithmic ${\cal O}(m_μα^6)$ terms, as well as the leading ${\cal O}(m_μα^5 \frac{m_μ^2}{m_ρ^2})$ hadronic effects. The latter are controlled by the chiral theory, which allows for their model independent determination. In this paper we give the missing piece for their complete expression including the pion and Delta particles. Out of this analysis and the experimental measurement of the muonic hydrogen Lamb shift we determine the electromagnetic proton radius: $r_p=0.8412(15)$ fm. This number is at 6.8$σ$ variance with respect to the CODATA value. The accuracy of our result is limited by uncomputed terms of ${\cal O}(m_μα^5\frac{m_μ^3}{m_ρ^3},m_μα^6)$. This parametric control of the uncertainties allows us to obtain a model independent determination of the error, which is dominated by hadronic effects.
description: 5 pages, 1 figure. Extensive changes in the discussion. References added. Some numbers changed. Main conclusion unchanged
The seismically active Mt. Hochstaufen, Bad Reichenhall (Germany)
Creators: name: Schlömer, Antje
name: Wassermann, Joachim
name: Metzger, Sabrina
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Active seismicity
subject: Northern Alps
subject: 500 Natural sciences and mathematics::550 Earth sciences::550 Earth sciences

description: For centuries, the Mt. Hochstaufen/Bad Reichenhall region in the Northern Alps has been affected by single earthquakes with magnitudes up to M3.2 or by irregular swarms. Most of the swarms occur during summer, often accompanied by strong precipitation, suggesting a direct correlation of seismicity and rainfall. A swarm in 2019 comprised many earthquakes with high magnitudes but a synchronous strong rain event is missing. Consequently, precipitation and tectonic background stress cannot be the sole explanation for the unusual high local seismicity. A trans-disciplinary study combining seismological analysis, meteorological and geodetic observations of the last years was proposed to identify the set of acting forces. Here, we present the first results of the seismological analyses and of the ground-based radar measurement performed at three measuring points surrounding Mt Hochstaufen. The relocation and clustering of earthquakes of the last decade, enables to distinguish between one-time occurrence of fault mechanisms limited to one swarm and faults reactivated with a distinct (yearly) periodicity. Beside a subsidence of the Bad Reichenhaller basin west of the Saalach river, the ground-based radar measurements show the opening of prominent fractures at both flanks of the mountain.
Chiral anomaly, dimensional reduction, and magnetoresistivity of Weyl and Dirac semimetals
Creators: name: Gorbar, E. V.
name: Miransky, V. A.
name: Shovkovy, I. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: By making use of the Kubo formula, we calculate the conductivity of Dirac and Weyl semimetals in a magnetic field. We find that the longitudinal (along the direction of the magnetic field) magnetoresistivity is negative at sufficiently large magnetic fields for {\it both} Dirac and Weyl semimetals. The physical reason of this phenomenon is intimately connected with the dimensional spatial reduction $3 \to 1$ in the dynamics of the lowest Landau level. The off-diagonal component of the transverse (with respect to the direction of the magnetic field) conductivity in Weyl semimetals contains an anomalous contribution directly proportional to the momentum space separation between the Weyl nodes. This contribution comes exclusively from the lowest Landau level and, as expected, is independent of the temperature, chemical potential, and magnetic field. The other part of the off-diagonal conductivity is the same as in Dirac semimetals and is connected with a nonzero density of charge carriers. The signatures for experimental distinguishing Weyl semimetals from Dirac ones through the measurements of conductivity are discussed.
description: v2: 17 pages, 5 multi-panel figures; published version with minor changes and new references added
Metal- and Oxidant-Free Photoinduced Aromatic Trifluoromethylation Performed in Aerated Gel Media: Determining the Effects on Yield and Selectivity
Creators: name: Abramov, Alex
name: Vernickel, Hendrik
name: Saldías, César
name: Diaz Diaz, David
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: trifluoromethylation; photoinduced reaction; chemoselectivity; supramolecular gel; confined reaction media
subject: 540 Chemie

description: In this work we have investigated the potential benefits of using supramolecular gel networks as reaction media to carry out air-sensitive metal-free light-induced trifluoromethylation of six-membered (hetero)arenes under aerobic conditions. This reaction was performed at room temperature (RT) using sodium triflinate (CF3SO2Na, Langlois’ reagent) as a source of radicals and diacetyl as electron donor. The effects of confinement in gel media, concentration of reactants, and type of light source on yield and product distribution were evaluated and compared to the results obtained in homogeneous solution. Four different low molecular weight (LMW) gelators were employed in this study. The results confirmed the blocking effect of the gel medium against reaction quenching by external oxygen, as well as a certain control on the kinetics and selectivity.
Deep learning based maximum power point predictionfor Arduino controlled solar water pumping systems
Creators: name: K. Punitha
name: V. Seetharaman
name: D. Devaraj
name: V. Selvaganesh
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: deep learning
LSTM network
prediction
incremental conductance MPPT
Proteus
python
Arduino UNO

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 884-891
A classification of $SU(d)$-type C$^*$-tensor categories
Creators: name: Jordans, Bas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: Kazhdan and Wenzl classified all rigid tensor categories with fusion ring isomorphic to the fusion ring of the group $SU(d)$. In this paper we consider the C$^*$-analogue of this problem. Given a rigid C$^*$-tensor category $\mathcal{C}$ with fusion ring isomorphic to the fusion ring of the group $SU(d)$, we can extract a constant $q$ from $\mathcal{C}$ such that there exists a $*$-representation of the Hecke algebra $H_n(q)$ into $\mathcal{C}$. The categorical trace on $\mathcal{C}$ induces a Markov trace on $H_n(q)$. Using this Markov trace and a representation of $H_n(q)$ in $\textrm{Rep}\,(SU_{\sqrt{q}}(d))$ we show that $\mathcal{C}$ is equivalent to a twist of the category $\textrm{Rep}\,(SU_{\sqrt{q}}(d))$. Furthermore a sufficient condition on a C$^*$-tensor category $\mathcal{C}$ is given for existence of an embedding of a twist of $\textrm{Rep}\,(SU_{\sqrt{q}}(d))$ in $\mathcal{C}$.
description: 29 pages; Inserted definition 2.3 and remark 2.4; Inserted notation 3.8 and slightly adapted lemma 3.9; Inserted remark 4.3 and adapted the proof of proposition 4.4; Corrected a number of misprints
Marginal stability in jammed packings: quasicontacts and weak contacts
Creators: name: Kallus, Yoav
name: Torquato, Salvatore
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Maximally random jammed (MRJ) sphere packing is a prototypical example of a system naturally poised at the margin between underconstraint and overconstraint. This marginal stability has traditionally been understood in terms of isostaticity, the equality of the number of mechanical contacts and the number of degrees of freedom. Quasicontacts, pairs of spheres on the verge of coming in contact, are irrelevant for static stability, but they come into play when considering dynamic stability, as does the distribution of contact forces. We show that the effects of marginal dynamic stability, as manifested in the distributions of quasicontacts and weak contacts, are consequential and nontrivial. We study these ideas first in the context of MRJ packing of d-dimensional spheres, where we show that the abundance of quasicontacts grows at a faster rate than that of contacts. We reexamine a calculation of Jin et al. (Phys. Rev. E 82, 051126, 2010), where quasicontacts were originally neglected, and we explore the effect of their inclusion in the calculation. This analysis yields an estimate of the asymptotic behavior of the packing density in high dimensions. We argue that this estimate should be reinterpreted as a lower bound. The latter part of the paper is devoted to Bravais lattice packings that possess the minimum number of contacts to maintain mechanical stability. We show that quasicontacts play an even more important role in these packings. We also show that jammed lattices are a useful setting for studying the Edwards ensemble, which weights each mechanically stable configuration equally and does not account for dynamics. This ansatz fails to predict the power-law distribution of near-zero contact forces, $P(f)\sim f^θ$.
description: final submitted version
Novel selective butyrylcholinesterase inhibitors incorporating antioxidant functionalities as potential bimodal therapeutics for Alzheimer’s Disease
Creators: name: Jones, Mike
name: Wang, Jun
name: Harmon, S.
name: Kling, Beata
name: Heilmann, Jörg
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: FERULIC ACID HYBRIDS; LIPOIC ACID; OXIDATIVE STRESS; CHOLINESTERASE-INHIBITORS; NEURONAL CELLS; ACETYLCHOLINESTERASE; FLAVONOIDS; DESIGN; MOUSE; ESTER; neuroprotection; Alzheimer's disease; antioxidant; cholinesterase inhibitor; hybrid
subject: 540 Chemie

description: Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be replaced with an antioxidant functionality while maintaining inhibitor effects and selectivity. We successfully incorporated ferulic acid or lipoic acid groups producing potent selective inhibitors of butyrylcholinesterase (BuChE). The hybrid compounds were non-toxic to the murine hippocampal cell line HT-22 and lipoate esters were neuroprotective at 10 and 25 mu M when the cells were challenged with glutamate (5 mM) in a similar manner to the positive control quercetin. The benzyl carbamate 7a was a potent inhibitor of BuChE (IC50 150 nM) and it was effective in reducing glutamate toxicity to neuronal cells at >5 mu M. Representative compounds exhibited an antioxidant effect in the oxygen radical absorbance capacity assay as the lipoate 7d was not active, whereas the ferulate 8a showed a weak, but significant, activity with 0.635 +/- 0.020 Trolox Equivalent.
The cone of curves and the Cox ring of rational surfaces given by divisorial valuations
Creators: name: Galindo, Carlos
name: Monserrat, Francisco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We consider surfaces $X$ defined by plane divisorial valuations $ν$ of the quotient field of the local ring $R$ at a closed point $p$ of the projective plane $\mathbb{P}^2$ over an arbitrary algebraically closed field $k$ and centered at $R$. We prove that the regularity of the cone of curves of $X$ is equivalent to the fact that $ν$ is non positive on ${\mathcal O}_{\mathbb{P}^2}(\mathbb{P}^2\setminus L)$, where $L$ is a certain line containing $p$. Under these conditions, we characterize when the characteristic cone of $X$ is closed and its Cox ring finitely generated. Equivalent conditions to the fact that $ν$ is negative on ${\mathcal O}_{\mathbb{P}^2}(\mathbb{P}^2\setminus L) \setminus k$ are also given.
description: Three references added with respect to the first version
Noise at sea: Characterization of extended shift noise exposures among U.S. navy aircraft carrier support personnel
Creators: name: Schaal, Nicholas Cody
name: Lange, Kevin
name: Majar, Maria
Publisher: name: F1000 Research Limited
Year: 2019

description: The purpose of this investigation was to characterize 12-hr on-duty, 12-hr off-duty, and 24-hr noise exposures among U.S. Navy aircraft carrier support personnel.  Noise dosimetry samples were collected for 47 aircraft carrier support personnel while at sea during airwing carrier qualifications.  Leq measurements during 12-hr on-duty, 12-hr off-duty, and over 24-hr periods were compared to Threshold Limit Values.  Four similar exposure groups (SEGs) were created based upon departmental assignment and similarity of work tasks: (1) Administration/Religious Ministries/Legal/Training, (2) Combat Systems/Operations, (3) Medical/Dental, and (4) Supply.  Equivalent sound level (Leq) measurements in decibels “A” weighted (dBA) were compared to determine significant differences between each group according to 12-hr on-duty, 12-hr off-duty, and 24-hr periods.  Mean 24-hr noise levels ranged from 69-88 dBA with 22% exceeding the 80 dBA Threshold Limit Value.  Twelve-hr on-duty noise levels ranged from 71-90 dBA with 17% exceeding the 83 dBA 12-hr on-duty Threshold Limit Value.  Twelve-hr off-duty noise exposure ranged from 68-84 dBA with 95% exceeding the 70 dBA American Conference of Governmental Industrial Hygienists threshold classified as effective quiet to allow for temporary threshold shift recovery.  Welch Analysis of Variance and Dunnett T3 post hoc tests revealed SEG 2 had significantly higher 24-hr noise exposures than SEG 3 (p = 0.019) and SEG 4 (p = 0.045).  SEG 2 had significantly higher 12-hr on-duty noise exposure than SEG 3 (p = 0.030).  One Way Analysis of Variance revealed no significant differences between 12-hr off-duty noise exposures according to SEG (p = .096).  Some aircraft carrier support personnel had 12-hr on-duty and 24-hr noise exposures exceeding Threshold Limit Values with a large proportion exceeding the 70 dBA effective quiet limit during 12-hr off-duty periods.  Results suggest personnel that are typically considered low risk for hazardous noise exposure (<85 dBA) during 8-hr shifts may have a greater risk of noise exposure when considering full 12-hr and 24-hr shifts when working and living in close proximity.
Effect of V-cut on the performanceof a longitudinal vortex generator using CFD
Creators: name: Ishu Shukla
name: Yatish Kumar Baghel
name: Patel, Vivek Kumar
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: friction factor
PEC
turbulence modelling
V-cut vortex generator

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 892-898
Cyrtopeltocoris hallodapoides Wyniger & Schuh & Henry 2023, new species
Creators: name: Wyniger, Denise
name: Schuh, Randall T.
name: Henry, Thomas J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Miridae
Cyrtopeltocoris
Cyrtopeltocoris hallodapoides

description: Cyrtopeltocoris hallodapoides, new species Figures 2, 5, 6, table 1 DIAGNOSIS: Recognized by the dull granular surface texture of the very weakly elevated pronotum (fig. 2) and the dartlike spine embedded in the apical membrane of the endosoma (fig. 5). Most similar in appearance to C. brailovskyi (fig. 1) based on granular surface of the head, pronotum, and scutellum, but larger and lacking the long erect setae on the antennae in that species. DESCRIPTION: Male: Total length 3.06. Weakly elongate, nearly parallel sided. Coloration (fig. 2): Head dark reddish brown; antennae dark reddish brown, labium brown; pronotum dark reddish brown; mesoscutum and scutellum dark reddish brown; scent-gland auricle brown or reddish brown; clavus orange brown basally, white medially and brown apically; brown corium interrupted medially by white transverse fascia; basally with a roundish white spot adjacent to cuneus not attaining inner margin of corium; cuneus reddish; membrane translucent, weakly fuscous; venter brown; mesepisternum dark reddish brown; all coxae dark reddish brown, trochanters ivory; femora and tibia dark reddish brown; tarsi brown (fig. 2). Surface and vestiture (fig. 2): Head, pronotum, and scutellum dull, granular; vertex and pronotum bearing recumbent setae; corium with recumbent and simple erect setae; antennae bearing long erect setae. Structure (fig. 2): Nearly parallel sided; scutellum weakly swollen; corium with lateral margin slightly convex basally at level of brown coloration; labium just surpassing apex of metacoxa. genitalia (fig. 5): Endosoma relatively short with limited coiling, ending in membranous lobe bearing dartlike sclerotized spine (fig. 5); phallotheca strongly curved, ending in rounded apex; left paramere with anterior process short and stout; posterior process elongate and distinctly curved downward; right paramere roundish with pointed apex. ETYMOLOGY: Named for the similarity of its appearance to members of the genus Hallodapus Fieber. DISTRIBUTION (fig. 6): Known from Baja California Sur. HOLOTYPE male: MEXICO: Baja California Sur: El Sargento, 24.07806 ° N 109.99972 ° W, 29 Jul 1971, H.G. Real and R.E. Main (AMNH _ PBI 00078654) (CAS).
description: Published as part of Wyniger, Denise, Schuh, Randall T. & Henry, Thomas J., 2023, Revision of the North American Hallodapini (Insecta: Hemiptera: Heteroptera: Miridae: Phylinae), pp. 1-48 in American Museum Novitates 2023 (3994) on pages 28-29, DOI: 10.1206/3994.1, http://zenodo.org/record/7710041
Glacial and erosional contributions to Late Quaternary uplift of the European Alps (GEOLQUEA)
Creators: name: Scherler, Dirk
name: Werner, Helen
name: Winkelmann, Ricarda
name: Jouvet, Guillaume
name: Klemann, Volker
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Ice sheet modelling
subject: Late Quaternary uplift
subject: European Alps
subject: 500 Natural sciences and mathematics::550 Earth sciences::550 Earth sciences

description: Isostatic adjustments of the Earth’s surface to changes in water, ice, and sediment loading are important contributions to present-day uplift/subsidence rates in many regions on Earth. In the absence of significant horizontal tectonic shortening in the central and western parts of the European Alps, uplift rates larger than 2 mm/yr are difficult to explain by geodynamic processes and have been a matter of debate for many decades. Here we examine the likely contribution of glacial isostatic adjustment in the European Alps in response to changes in ice loading using state of the art ice flow and lithospheric numerical modeling. In contrast to a similar previous approach (Mey et al., 2016), we employ a transient ice sheet model over the last glacial cycle (100 kyr) in combination with a spherical viscoelastic solid earth model. We present ice model results using the Instructed Glacier Model (Jouvet et al., 2021), in which we tested the effect of spatial resolution on the growth and extent of the European ice cap. We found significant differences using a model resolution of 200 m compared to a resolution of 2000 m, which is commonly used in large-scale glacier modeling studies. These differences result in near-steady state volumetric differences at the maximum ice extent of +13% for the high compared to the low-resolution model. In addition, we observed periods of marked ice growth that initiated at significantly different times for the different resolution models. Therefore, we conclude that a realistic ice loading history requires a sufficiently high spatial resolution, which is significantly higher than used in previous models. Based on the modeled ice loading histories, we used the lithosphere and mantle model VILMA (Klemann et al., 2008, J. Geodyn.) to predict the vertical land motion. These estimates are based on a global 60 km thick elastic lithosphere, followed by a 200 km thick viscous layer with a viscosity of 1020 Pa s, which increases to 5 x 1020 Pa s down to 670 km depth, and 3.16 x 1021 Pa s to the core mantle boundary. Preliminary results indicate similar first-order lithospheric responses, with spatiotemporal differences in the magnitude of postglacial response. We hope to present more results based on further ice models that are forced by a more realistic climate history.
Free convection of an electrically conducting fluid in a micro-channelwith super-hydrophobic slip condition
Creators: name: Ramanuja, Mani
name: G. Gopi Krishna
name: V. Naga Radhika
name: K. Maruthi Prasad
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2022
Subjects: MHD
Buoyancy parameter
super-hydrophobic slip
Radiation
heat transfer

description: Songklanakarin Journal of Science an Technology (SJST), 44, 3, 899-906
Keratin protein-catalyzed nitroaldol (Henry) reaction and comparison with other biopolymers
Creators: name: Häring, Marleen
name: Pettignano, Asja
name: Quignard, F.
name: Tanchoux, Nathalie
name: Diaz Diaz, David
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: C BOND FORMATION; BIOMATERIALS; FILAMENTS; SEQUENCE; keratin; biopolymer; C-C bond formation; nitroaldol reaction; Henry reaction
subject: 540 Chemie

description: Here we describe a preliminary investigation on the ability of natural keratin to catalyze the nitroaldol (Henry) reaction between aldehydes and nitroalkanes. Both aromatic and heteroaromatic aldehydes bearing strong or moderate electron-withdrawing groups were converted into the corresponding -nitroalcohol products in both DMSO and in water in the presence of tetrabutylammonium bromide (TBAB) as a phase transfer catalyst. Negligible background reactions (i.e., negative control experiment in the absence of keratin protein) were observed in these solvent systems. Aromatic aldehydes bearing electron-donating groups and aliphatic aldehydes showed poor or no conversion, respectively. In general, the reactions in water/TBAB required twice the amount of time than in DMSO to achieve similar conversions. Moreover, comparison of the kinetics of the keratin-mediated nitroaldol (Henry) reaction with other biopolymers revealed slower rates for the former and the possibility of fine-tuning the kinetics by appropriate selection of the biopolymer and solvent.
Reconciling neutrino flux from heavy dark matter decay and recent events at IceCube
Creators: name: Bhattacharya, Atri
name: Reno, Mary Hall
name: Sarcevic, Ina
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The IceCube detector has recently reported the observation of 28 events at previously unexplored energies. While the statistics of the observed events are still low, these events hint at the existence of a neutrino flux over and above the atmospheric neutrino background. We investigate the possibility that a significant component of the additional neutrino flux originates due to the decay of a very heavy dark matter (VHDM) particle via several possible channels into standard model particles. We show that a combination of a power law astrophysical neutrino spectrum and the neutrino flux from the decay of a DM species of mass in the range $150-400$ TeV improves the fit to the observed neutrino events than that obtained from a best-fit astrophysical flux alone. Assuming the existence of an astrophysical background described by the IC best-fit, we also show that, for the decay of even heavier DM particles ($m_{\text{DM}} \sim 1$ PeV), the same observations impose significant constraints on the decay lifetimes. Allowing the astrophysical flux normalization to vary leads to modifications of these limits, however, there is still a range of dark matter mass and lifetime that is excluded by the IC results.
description: v1: 8 pages, 2 figures, 2 tables. v2: Minimization over three-parameters (DM mass, lifetime and astrophysical power-law flux normalization); better statistical quantification of fit-goodness; conclusions unchanged; 15 pg, 3 figs, 2 tables; version to appear in JHEP
BM Genel Kurulu Holokost'un İnkarını Reddetip Kınadı Ve Reddinin Uluslararası Hukuki Temelini Hatırlattı
Creators: name: Tulun, Teoman Ertuğrul
Publisher: name: Zenodo
Year: 2022
Subjects: 1948 Soykırım Sözleşmesi
Birleşmiş Milletler
Holokost

description: Birleşmiş Milletler Genel Kurulu (UNGA) 20 Ocak 2022'de Holokost'un inkarına ilişkin bir kararı kabul etmiş ve "Holokost'un tamamen veya kısmen tarihsel bir olay olarak inkarını çekincesiz " reddetmiş ve kınamıştır. Karar, ifade özgürlüğü hakkının kullanımını yeniden teyit etmektedir. Karar, Holokost'un Yahudi toplumunun üçte birini oluşturan, 1,5 milyonu çocuk olmak üzere 6 milyona yakın Yahudi'nin öldürülmesiyle sonuçlandığını bir kez daha teyit etmekte ve Nürnberg Mahkemesi'nin Holokost'un Nazi faillerine ilişkin kararlarının uluslararası hukuki temeline şu şekilde dikkat çekmektedir: "Nürnberg Mahkemesi Şartı tarafından tanınan uluslararası hukuk ilkelerini yineleyerek ve bunların 1950'de Uluslararası Hukuk Komisyonu tarafından kodifikasyonunu takdirle not ederek." Bu bağlamda, uluslararası hukuk açısından "soykırım" terimi, Soykırım Sözleşmesi aracılığıyla hukuk terminolojisinde yerini bulan bir hukuk terimidir. Dolayısıyla, soykırımın varlığının tespiti ve cezalandırılmasına ilişkin uluslararası hukuk bağlamında hukuken bağlayıcı tek ve temel anlaşma olan Soykırım Sözleşmesi, hiçbir şekilde geriye dönük olarak uygulanamaz. Tutanaklarda kararın, Nazi liderlerinin Avrupa'da 11 milyona yakın Yahudi'nin sistematik olarak katledilmesini görüşmek üzere Berlin'in Wannsee gölü kıyısındaki bir villada bir araya geldiği Wannsee Konferansı'nın 80. yıl dönümünde kabul edildiği belirtiliyor. Almanya'nın BM Daimi Temsilciliği tarafından yapılan bir basın açıklamasına göre, bu kararla, "Bir BM kararında ilk kez, Holokost inkarının ne olduğuna dair bir tanım” eklenebilmesi imkanı doğmuştur. Çeşitli AVİM analizlerimizde Alman toplumunda aşırı sağın yükselişi ve Müslüman karşıtı ırkçılık olarak da tanımlanabilecek İslamofobinin yükselişi gibi gelişmelere dikkat çektik. Bu bağlamda, Alman Z kuşağının geçmişteki gelişmeler ile bugün Alman toplumunun karşı karşıya olduğu ırkçılık ve ayrımcılık gibi acil sorunlar arasında yukarıda da belirtildiği gibi benzerlik kurmasının haklı sebepleri olduğunu belirtmek gerekir. Bu kapsamda, incelememizde 2000-2007 yılları arasında sekizi Almanya'da yaşayan Türklerden oluşmak üzere on kişiyi katleden neo-Nazi Nasyonal Sosyalist Yeraltı (NSU) terör örgütü hakkında ayrıntılı bilgi verdik. Almanya'da ve çoğu Batı Avrupa ülkesinde Holokost inkarındaki yükselişin yanı sıra ırkçılık, yabancı düşmanlığı ve İslamofobinin yükselişte olduğu bariz bir gelişmedir.
Nonlinear vs. bolometric radiation response and phonon thermal conductance in graphene-superconductor junctions
Creators: name: Vora, Heli
name: Nielsen, Bent
name: Du, Xu
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Graphene is a promising candidate for building fast and ultra-sensitive bolometric detectors due to its weak electron-phonon coupling and low heat capacity. In order to realize a practical graphene-based bolometer, several important issues, including the nature of radiation response, coupling efficiency to the radiation and the thermal conductance need to be carefully studied. Addressing these issues, we present graphene-superconductor junctions as a viable option to achieve efficient and sensitive bolometers, with the superconductor contacts serving as hot electron barriers. For a graphene-superconductor device with highly transparent interfaces, the resistance readout in the presence of radio frequency radiation is dominated by non-linear response. On the other hand, a graphene-superconductor tunnel device shows dominantly bolometric response to radiation. For graphene devices fabricated on $SiO_{2}$ substrates, we confirm recent theoretical predictions of $T^{2}$ temperature dependence of phonon thermal conductance in the presence of disorder in the graphene channel at low temperatures.
Flavour Covariant Transport Equations: an Application to Resonant Leptogenesis
Creators: name: Dev, P. S. Bhupal
name: Millington, Peter
name: Pilaftsis, Apostolos
name: Teresi, Daniele
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a fully flavour-covariant formalism for transport phenomena, by deriving Markovian master equations that describe the time-evolution of particle number densities in a statistical ensemble with arbitrary flavour content. As an application of this general formalism, we study flavour effects in a scenario of resonant leptogenesis (RL) and obtain the flavour-covariant evolution equations for heavy-neutrino and lepton number densities. This provides a complete and unified description of RL, capturing three distinct physical phenomena: (i) the resonant mixing between the heavy-neutrino states, (ii) coherent oscillations between different heavy-neutrino flavours, and (iii) quantum decoherence effects in the charged-lepton sector. To illustrate the importance of this formalism, we numerically solve the flavour-covariant rate equations for a minimal RL model and show that the total lepton asymmetry can be enhanced by up to one order of magnitude, as compared to that obtained from flavour-diagonal or partially flavour off-diagonal rate equations. Thus, the viable RL model parameter space is enlarged, thereby enhancing further the prospects of probing a common origin of neutrino masses and the baryon asymmetry in the Universe at the LHC, as well as in low-energy experiments searching for lepton flavour and number violation. The key new ingredients in our flavour-covariant formalism are rank-4 rate tensors, which are required for the consistency of our flavour-mixing treatment, as shown by an explicit calculation of the relevant transition amplitudes by generalizing the optical theorem. We also provide a geometric and physical interpretation of the heavy-neutrino degeneracy limits in the minimal RL scenario. Finally, we comment on the consistency of various suggested forms for the heavy-neutrino self-energy regulator in the lepton-number conserving limit.
description: 109 pages, 14 figures, 5 tables; typos corrected; final published version
title: Understanding the neurobiological basis of anhedonia in major depressive disorder — evidence for reduced neural activation during reward and loss processing
Creators: name: Steinmann, Lavinia A.
name: Dohm, Katharina
name: Goltermann, Janik
name: Richter, Maike Frederike
name: Enneking, Verena
name: Lippitz, Marcia
name: Repple, Jonathan
name: Mauritz, Marco
name: Dannlowski, Udo
name: Opel, Nils
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: Background: Anhedonia is a key symptom of major depressive disorder (MDD). Anhedonia is associated with aberrant reward processing, but whether it might interfere similarly with the neural processing of aversive stimuli, such as monetary loss, remains unknown. We aimed to investigate potential associations between anhedonia and neural response during reward and loss processing in patients with MDD. Methods: We investigated blood-oxygen-level-dependent response in the orbitofrontal cortex, cingulate cortex, insula and basal ganglia during monetary reward and loss processing in 182 patients with MDD, using a card-guessing paradigm. We measured anhedonia with the Social and Physical Anhedonia Scale (SASPAS), and we tested for the main and interaction effects of SASPAS scores and the experimental condition (reward or loss) in a full factorial model. Results: We detected a negative main effect of anhedonia, as well as a significant interaction effect of anhedonia and the experimental condition, on orbitofrontal and insular neural response. Post hoc analyses revealed that the interaction was driven by a significant association between higher anhedonia scores and hypoactivation during loss processing. We observed no significant association between anhedonia and neural response during reward processing. Limitations: This study had a cross-sectional design. Conclusion: Our findings confirmed that altered neural processing in the orbitofrontal cortex and insula is a neurobiological feature of anhedonic symptomatology in people with MDD. The pronounced association between anhedonia and blunted neural response during loss processing supports a broader concept for the neurobiological basis of anhedonia. Hence, MDD with anhedonic features might be characterized by reduced neural response to external stimuli, potentially because of amotivation.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).