cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Online Read Ebook Balada de nunca jamás, La by Stephanie Garber
Creators: name: Moran
Publisher: name: Zenodo
Year: 2024

description: Balada de nunca jamás, La by Stephanie Garber

 

 

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Balada de nunca jamás, La

Stephanie Garber

Page: 416

Format: pdf, ePub, mobi, fb2

ISBN: 9788417854928

Publisher: Urano Publishing, Inc.

 

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A New Approach to an Old Problem: The Reconstruction of a Go Game through a Series of Photographs
Creators: name: Corsolini, Mario
name: Carta, Andrea
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences
subject: I.2.10; I.4.8; I.5.5

description: Given a series of photographs taken during a Go game, we describe the techniques we successfully employ for pinpointing the grid lines of the Go board and for tracking their small movements between consecutive photographs; then we discuss how to approximate the location and orientation of the observer's point of view, in order to compensate for projection effects. Finally we describe the different criteria that jointly form the algorithm for stones' detection, thus enabling us to automatically reconstruct the whole move sequence.
description: 13 pages, 18 figures, datasets available from http://www.oipaz.net/VideoKifu.html - added references in section 1, updated addresses, added indication that both authors contributed equally
(3218) Alice Margaret [Leigh]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
BottleFit: Learning Compressed Representations in Deep Neural Networks for Effective and Efficient Split Computing
Creators: name: Matsubara, Yoshitomo
name: Callegaro, Davide
name: Singh, Sameer
name: Levorato, Marco
name: Restuccia, Francesco
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Image and Video Processing (eess.IV)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Although mission-critical applications require the use of deep neural networks (DNNs), their continuous execution at mobile devices results in a significant increase in energy consumption. While edge offloading can decrease energy consumption, erratic patterns in channel quality, network and edge server load can lead to severe disruption of the system's key operations. An alternative approach, called split computing, generates compressed representations within the model (called "bottlenecks"), to reduce bandwidth usage and energy consumption. Prior work has proposed approaches that introduce additional layers, to the detriment of energy consumption and latency. For this reason, we propose a new framework called BottleFit, which, in addition to targeted DNN architecture modifications, includes a novel training strategy to achieve high accuracy even with strong compression rates. We apply BottleFit on cutting-edge DNN models in image classification, and show that BottleFit achieves 77.1% data compression with up to 0.6% accuracy loss on ImageNet dataset, while state of the art such as SPINN loses up to 6% in accuracy. We experimentally measure the power consumption and latency of an image classification application running on an NVIDIA Jetson Nano board (GPU-based) and a Raspberry PI board (GPU-less). We show that BottleFit decreases power consumption and latency respectively by up to 49% and 89% with respect to (w.r.t.) local computing and by 37% and 55% w.r.t. edge offloading. We also compare BottleFit with state-of-the-art autoencoders-based approaches, and show that (i) BottleFit reduces power consumption and execution time respectively by up to 54% and 44% on the Jetson and 40% and 62% on Raspberry PI; (ii) the size of the head model executed on the mobile device is 83 times smaller. We publish the code repository for reproducibility of the results in this study.
description: Accepted to IEEE WoWMoM 2022. Code and models are available at https://github.com/yoshitomo-matsubara/bottlefit-split_computing
Non-Hermitian physics and master equations
Creators: name: Roccati, Federico
name: Palma, G. Massimo
name: Bagarello, Fabio
name: Ciccarello, Francesco
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A longstanding tool to characterize the evolution of open Markovian quantum systems is the GKSL (Gorini-Kossakowski-Sudarshan-Lindblad) master equation. However, in some cases, open quantum systems can be effectively described with non-Hermitian Hamiltonians, which have attracted great interest in the last twenty years due to a number of unconventional properties, such as the appearance of exceptional points. Here, we present a short review of these two different approaches aiming in particular to highlight their relation and illustrate different ways of connecting non-Hermitian Hamiltonian to a GKSL master equation for the full density matrix.
description: 10 pages, 7 figures. Submitted to the Special Issue of OSID in memoriam of Andrzej Kossakowski
Superelasticity of Carbon Nanocoils from Atomistic Quantum Simulations
Creators: name: Gao, Hai Li
name: Liu, Li Zhao
name: Lu, Jian Ping
name: Zhao, Ji Jun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A structural model of carbon nanocoils (CNCs) on the basis of carbon nanotubes (CNTs) was proposed. The Young’s moduli and spring constants of CNCs were computed and compared with those of CNTs. Upon elongation and compression, CNCs exhibit superelastic properties that are manifested by the nearly invariant average bond lengths and the large maximum elastic strain limit. Analysis of bond angle distributions shows that the three-dimensional spiral structures of CNCs mainly account for their unique superelasticity.
Download PDF Framed Perspective Vol. 1: Technical Drawing for Visual Storytelling by Marcos Mateu-Mestre
Creators: name: Brown
Publisher: name: Zenodo
Year: 2024

description: Framed Perspective Vol. 1: Technical Drawing for Visual Storytelling by Marcos Mateu-Mestre

 

 

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Framed Perspective Vol. 1: Technical Drawing for Visual Storytelling

Marcos Mateu-Mestre

Page: 228

Format: pdf, ePub, mobi, fb2

ISBN: 9781624650307

Publisher: Design Studio Press

 

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Best book torrent sites Download it here and read it on your Kindle device. New eBook was published downloads zip Framed Perspective Vol. 1: Technical Drawing for Visual Storytelling EPUB PDF Download Read Marcos Mateu-Mestre Audio Download, Unabridged. Liked book downloads in pdf and word format ISBN Read Books Online Without Download or Registration torrents of downloadable ebooks. Downloading from the publisher EPUB Framed Perspective Vol. 1: Technical Drawing for Visual Storytelling By Marcos Mateu-Mestre PDF Download. Check this ebook now Pages Published Publisher.

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Online Read Ebook Accueillir  - Venu(e)s d'un ventre ou d'un pays
Creators: name: Alexander
Publisher: name: Zenodo
Year: 2024

description: Accueillir - Venu(e)s d'un ventre ou d'un pays pan Marie-José Mondzain

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Accueillir - Venu(e)s d'un ventre ou d'un pays

Marie-José Mondzain

Nb. de pages: 248

Format: Pdf, ePub, MOBI, FB2

ISBN: 9791020924377

Editeur: Les Liens qui Libèrent

Date de parution: 2023

 

 

 

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Overview

Naitre biologiquement ne suffit pas. Encore faut-il être adopté. À cet égard, tout nourrisson est un enfant adopté. Voir les choses ainsi change (presque) tout. La filiation biologique, et donc l'arrivée d'un nouveau-né dans une famille, n'est pas le modèle de l'accueil, mais, de façon contre-intuitive, l'un de ses cas particuliers.
(3215) John Geldert
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Northern Populism: Causes and Consequences of the New Ordered Outlook
Creators: name: Graves, Frank
name: Smith, Jeff
Publisher: name: The School of Public Policy Publications
Year: 2020

description: This paper examines the issue of whether of not authoritarian populism – or what we prefer to label ordered populism – is a force in Canada. There is clear evidence in the international literature that this force has been a critical factor in explaining the rise of Donald Trump in America, Brexit in the United Kingdom and similar examples in other advanced western democracies. The paper attempts to clarify the key concepts under discussion based on a cursory review of the recent and historical literature. Using this literature, we identify the key forces that seem to be linked to the emergence of ordered populism in other societies. These include economic stagnation and the rising concentration of wealth at the top of the social system, a magnified sense of external risk, a cultural backlash against the loss of core values for those embracing this outlook and a broad sense of normative tension – that the broadest direction of society is moving in the wrong direction. Using time series, we find clear evidence that the forces, which have been linked to the emergence of ordered populism, are evident in Canada. We then attempt to use more direct evidence that this force is in fact present in Canada. We measure public opinion as to whether the public believe it is here and whether it is a positive or negative force. We also use direct measures based on variations of indices that have been developed to measure this phenomenon. Using both of these measurement strategies, we find evidence that ordered populism is present in Canada and that it has been a major political force expressing itself in dramatically heightened partisan polarization (similar to what other researchers have found in the United States and the United Kingdom). As a more definitive test, we applied the open-ordered index and related tests to the recently completed Canadian election. Our testing showed that this index was an extremely powerful predictor of the election outcome. We conclude with some thoughts on the broad policy implications for this research.
description: The School of Public Policy Publications, Vol. 13 (2020)
Download PDF Emperador de Roma / Emperor of Rome by Mary Beard
Creators: name: Demers
Publisher: name: Zenodo
Year: 2024

description: Emperador de Roma / Emperor of Rome by Mary Beard

 

 

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Emperador de Roma / Emperor of Rome

Mary Beard

Page: 568

Format: pdf, ePub, mobi, fb2

ISBN: 9786075696126

Publisher: Planeta Publishing Corporation

 

Download ebook free rar Emperador de Roma / Emperor of Rome 9786075696126 (English Edition) by Mary Beard

Augustus - Caesar, Emperor & Accomplishments Nov 9, 2009 — Emperador de Roma / Emperor of Rome This book title, Emperador de Roma / Emperor of Rome, ISBN: 9786075696126, by Mary Beard, published by Planeta Publishing Corp (March 26, 2024) is available in  Vectores de Emperor rome Se encuentran disponibles 1,223 vectores, gráficos y arte gráfico para emperor rome libres de regalías. · Antigua Grecia y antigua Roma infografía tradición y  The Character of the Roman Emperor in the Auto de la El personaje del emperador romano en el Auto de la destrucción de Jerusalén ; Research output: ; Contribution to journal › ; ›  “Emperador de Roma” Mary Beard | Editorial Crítica - YouTube Con motivo del lanzamiento del libro “Emperador de Roma” Crea Lectura entrevista a Mary Beard que nos detalla algunos aspectos de su libro. Beard, Mary: Emperador de Roma / Emperor of Rome Emperador de Roma / Emperor of Rome, szerző: Beard, Mary, Kategória: Edad antigua, Ár: 10 217 Ft. Roman emperor | Spanish Translator The Roman emperor was Constantino, successor of Diocleciano in the throne. El emperador romano era Constantino, sucesor de Diocleciano en el trono. Meditations - Marcus Aurelio (emperador de Roma) Roman Emperor Marcus Aurelius wrote his famous "Meditations" during his campaigns against the barbarian invaders. Composed among the reeds and mists of the  El personaje del emperador romano en el Auto de la by SI Trujillo Valverde · 2021 — List of Roman emperors The Roman emperors were the rulers of the Roman Empire from the granting of the name and title Augustus to Octavian by the Roman Senate in 27 BC onward. Roman Emperor Roman Emperor s ruled the Roman Empire starting with Augustus in 27 BCE and continuing in the West until the late 5th century CE and in the Eastern Roman  Augusto [Augustus]: Una Fascinante Guía del Primer Augusto [Augustus]: Una Fascinante Guía del Primer Emperador de Roma y de Cómo Gobernó el Imperio Romano [A Captivating Guide to the First Emperor of Rome and  Marco Aurelio Antonino (121-180 d. C.), filósofo y Marco Aurelio Antonino (121-180 d. C.), filósofo y emperador de Roma, y la peste de Galeno. November 2012; Enfermedades Infecciosas y Microbiología Clínica 30(9):
(3216) Catharine Haslam
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supersolid Devil's Staircases of Spin-Orbit-Coupled Bosons in Optical Lattices
Creators: name: Yamamoto, Daisuke
name: Bannai, Kotaro
name: Furukawa, Nobuo
name: de Melo, Carlos A. R. Sá
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the emergence of supersolid Devil's staircases of spin-orbit coupled bosons loaded in optical lattices. We consider two- and three-dimensional systems of pseudo-spin-$1/2$ bosons interacting via local spin-dependent interactions. These interactions together with spin-orbit coupling produce length scales that are commensurate to the lattice spacing. This commensurability leads to Devil's staircases of supersolids, with fractal Hausdorff dimensions, which arise from uniform superfluid phases. We show that umklapp processes are essential for the existence of commensurate supersolids, and that without them the Devil's staircase does not exist. Lastly, we emphasize the generality of our results, suggest experiments that can unveil these unusual predictions, and discuss potential applications to the case of $^{87}$Rb.
description: 6 pages, 4 figures
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
Creators: name: Nishino, Mizuki
name: Xu, Chunxiao
name: Cameron, Michael D.
name: Hayes, D. Neil
name: Chirieac, Lucian R.
name: Ouyang, Jing
name: Butaney, Mohit
name: Pandolfi, Pier Paolo
name: Castrillon, Diego H.
name: Roberts, Patrick J.
name: Sharpless, Norman E.
name: Woo, Michele S.
name: Ebi, Hiromichi
name: Peña, Christopher G.
name: Lee, Charles
name: Chen, Zhao
name: Sun, Yanping
name: Costa, Daniel B.
name: Wang, Shumei
name: Engelman, Jeffrey A.
name: Altabef, Abigail
name: Franchetti, Yoko
name: Yanagita, Masahiko
name: Walton, Zandra
name: Wong, Kwok Kin
name: Saur, Amy
name: Wilkerson, Matthew D.
name: Bardeesy, Nabeel
name: Jänne, Pasi A.
name: Wang, Yuchuan
name: Yao, Catherine
name: Nakada, Yuji
name: Cheng, Katherine
name: Cantley, Lewis C.
name: Shimamura, Takeshi
name: Kung, Andrew L.
name: Demetri, George D.
name: Gao, Peng
name: Lee, Carrie B.
name: Jackman, David
name: Liu, Yan
name: Tupper, Tanya
name: Li, Jie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Targeted therapies have demonstrated efficacy against specific subsets of molecularly defined cancers1–4. Although most patients with lung cancer are stratified according to a single oncogenic driver, cancers harbouring identical activating genetic mutations show large variations in their responses to the same targeted therapy1,3. The biology underlying this heterogeneity is not well understood, and the impact of co-existing genetic mutations, especially the loss of tumour suppressors5–9, has not been fully explored. Here we use genetically engineered mouse models to conduct a ‘co-clinical’ trial that mirrors an ongoing human clinical trial in patients with KRAS-mutant lung cancers. This trial aims to determine if the MEK inhibitor selumetinib (AZD6244)10 increases the efficacy of docetaxel, a standard of care chemotherapy. Our studies demonstrate that concomitant loss of either p53 (also known as Tp53) or Lkb1 (also known as Stk11), two clinically relevant tumour suppressors6,9,11,12, markedly impaired the response of Kras-mutant cancers to docetaxel monotherapy. We observed that the addition of selumetinib provided substantial benefit for mice with lung cancer caused by Kras and Kras and p53 mutations, but mice with Kras and Lkb1 mutations had primary resistance to this combination therapy. Pharmacodynamic studies, including positron-emission tomography (PET) and computed tomography (CT), identified biological markers in mice and patients that provide a rationale for the differential efficacy of these therapies in the different genotypes. These co-clinical results identify predictive genetic biomarkers that should be validated by interrogating samples from patients enrolled on the concurrent clinical trial. These studies also highlight the rationale for synchronous co-clinical trials, not only to anticipate the results of ongoing human clinical trials, but also to generate clinically relevant hypotheses that can inform the analysis and design of human studies.
{pdf download} The Terminal List by Jack Carr
Creators: name: Sturgeon
Publisher: name: Zenodo
Year: 2024

description: The Terminal List by Jack Carr

 

 

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The Terminal List

Jack Carr

Page: 432

Format: pdf, ePub, mobi, fb2

ISBN: 9781982197261

Publisher: Atria/Emily Bestler Books

 

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Imaging Chern mosaic and Berry-curvature magnetism in magic-angle graphene
Creators: name: Grover, Sameer
name: Bocarsly, Matan
name: Uri, Aviram
name: Stepanov, Petr
name: Di Battista, Giorgio
name: Roy, Indranil
name: Xiao, Jiewen
name: Meltzer, Alexander Y.
name: Myasoedov, Yuri
name: Pareek, Keshav
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Yan, Binghai
name: Stern, Ady
name: Berg, Erez
name: Efetov, Dmitri K.
name: Zeldov, Eli
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Charge carriers in magic angle graphene come in eight flavors described by a combination of their spin, valley, and sublattice polarizations. When the inversion and time reversal symmetries are broken by the substrate or by strong interactions, the degeneracy of the flavors can be lifted and their corresponding bands can be filled sequentially. Due to their non-trivial band topology and Berry curvature, each of the bands is classified by a topological Chern number, leading to the quantum anomalous Hall and Chern insulator states at integer fillings $ν$ of the bands. It has been recently predicted, however, that depending on the local atomic-scale arrangements of the graphene and the encapsulating hBN lattices, rather than being a global topological invariant, the Chern number C may become position dependent, altering transport and magnetic properties of the itinerant electrons. Using a SQUID-on-tip, we directly image the nanoscale Berry-curvature-induced equilibrium orbital magnetism, the polarity of which is governed by the local Chern number, and detect its two constituent components associated with the drift and the self-rotation of the electronic wave packets. At $ν=1$, we observe local zero-field valley-polarized Chern insulators forming a mosaic of microscopic patches of C=-1, 0, or 1, governed by the local sublattice polarization, consistent with predictions. Upon further filling, we find a first-order phase transition due to recondensation of electrons from valley K to K', which leads to irreversible flips of the local Chern number and the magnetization, and to the formation of valley domain walls giving rise to hysteretic global anomalous Hall resistance. The findings shed new light on the structure and dynamics of topological phases and call for exploration of the controllable formation of flavor domain walls and their utilization in twistronic devices.
description: 29 pages, 5 main text figures and 8 supplementary figures
Novel role of PKR in inflammasome activation and HMGB1 release
Creators: name: Lundbäck, Peter
name: Tracey, Kevin J.
name: Zou, Yongrui
name: Wang, Haichao
name: Andersson, Ulf
name: Tang, Yiting
name: Erlandsson-Harris, Helena
name: Kalb, Thomas
name: Roth, Jesse
name: Inouye, Karen
name: Li, Jianhua
name: Yang, Huan
name: Lu, Ben
name: Olofsson, Peder S.
name: Ting, Jenny P.Y.
name: Valdes-Ferrer, Sergio I.
name: Chavan, Sangeeta S.
name: Antoine, Daniel J.
name: Hotamisligil, Gökhan S.
name: Nakamura, Takahisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA dependent protein kinase (PKR) in inflammasome activation. Exposure of macrophages to inflammasome agonists induced PKR autophosphorylation. PKR inactivation by genetic deletion or pharmacological inhibition severely impaired inflammasome activation in response to double-stranded RNA, ATP, monosodium urate, adjuvant aluminum, rotenone, live E. coli, anthrax lethal toxin, DNA transfection, and S. Typhimurium infection. PKR deficiency significantly inhibited the secretion of IL-1beta, IL-18 and HMGB1 in E. coli-induced peritonitis. PKR physically interacts with multiple inflammasome components, including NLR family pyrin domain-containing 3 (NLRP3), NLR family pyrin domain-containing 1 (NLRP1), NLR family CARD domain-containing protein 4 (NLRC4), Absent in melanoma 2 (AIM2), and broadly regulates inflammasome activation. PKR autophosphorylation in a cell free system with recombinant NLRP3, ASC and pro-casapse-1 reconstitutes inflammasome activity. These results reveal a critical role of PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.
Supernova Sweeping and Black-Hole Feedback in Elliptical Galaxies
Creators: name: Voit, G. M.
name: Donahue, M.
name: O'Shea, B. W.
name: Bryan, G. L.
name: Sun, M.
name: Werner, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Most of the massive elliptical galaxies in the universe stopped forming stars billions of years ago, even though plenty of hot gas remains available for star formation. Here we present compelling evidence indicating that quenching of star formation depends on both black-hole feedback and Type Ia supernova heating. We analyze Chandra X-ray observations of ten massive ellipticals, five with extended, potentially star-forming multiphase gas and five single-phase ellipticals with no star formation. The ratio of cooling time to freefall time at 1--10 kpc in the multiphase galaxies is tc/tff ~10, indicating that precipitation-driven feedback limits cooling but does not eliminate condensation. In the same region of the single-phase galaxies, the radial profiles of gas entropy are consistent with a thermally stable (tc/tff > 20) supernova-driven outflow that sweeps stellar ejecta out of the galaxy. However, in one of those single-phase ellipticals (NGC 4261) we find tc/tff < 10 at < 300 pc. Notably, its jets are ~50 times more powerful than in the other nine ellipticals, in agreement with models indicating that precipitation near the black hole should switch its fueling mode from Bondi-like accretion to cold chaotic accretion. We conclude by hypothesizing that particularly strong black-hole outbursts can shut off star formation in massive elliptical galaxies by boosting the entropy of the hot gas and flipping the system into the supernova-sweeping state.
description: ApJ Letters, in press, 5 pages, 2 figures, some typos corrected in v2
Read [pdf]> The Art of Splatoon 2 by Nintendo
Creators: name: Fairchild
Publisher: name: Zenodo
Year: 2024

description: The Art of Splatoon 2 by Nintendo

 

 

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The Art of Splatoon 2

Nintendo

Page: 384

Format: pdf, ePub, mobi, fb2

ISBN: 9781506713748

Publisher: Dark Horse Comics

 

Free online ebooks to download The Art of Splatoon 2 by Nintendo 9781506713748 (English Edition)

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Labelling and optical erasure of synaptic memory traces in the motor cortex
Creators: name: Kasai, Haruo
name: Shirai, Fukutoshi
name: Loshbaugh, Amanda L.
name: Nakamura, Mayumi
name: Yagishita, Sho
name: Kuhlman, Brian
name: Wu, Yi I.
name: Hayashi-Takagi, Akiko
name: Hahn, Klaus M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Dendritic spines are the major loci of synaptic plasticity and are considered as possible structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of spines in the cortex has been unattainable, and thus, the link between spines and memory has been correlational. We developed a novel synaptic optoprobe, AS-PaRac1 (activated synapse targeting photoactivatable Rac1), which can label recently potentiated spines specifically, and induce the selective shrinkage of AS-PaRac1-containing spines. In vivo imaging of AS-PaRac1 revealed that a motor learning induced substantial synaptic remodelling in a small subset of neurons. The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines, whereas it was not affected by the identical manipulation of spines evoked by a distinct motor task in the same cortical region. Taken together, our results demonstrate that a newly acquired motor skill depends on the formation of a task-specific dense synaptic ensemble.
Universality for low degree factors of random polynomials over finite fields
Creators: name: He, Jimmy
name: Pham, Huy Tuan
name: Xu, Max Wenqiang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 60C05 (Primary), 60B99, 11T06 (Secondary)

description: We show that the counts of low degree irreducible factors of a random polynomial $f$ over $\mathbb{F}_q$ with independent but non-uniform coefficients behave like that of a uniform random polynomial, exhibiting a form of universality for random polynomials over finite fields. Our strongest results require various assumptions on the parameters, but we are able to obtain results requiring only $q=p$ a prime with $p\leq \exp({n^{1/13}})$ where $n$ is the degree of the polynomial. Our proofs use Fourier analysis, and rely on tools recently applied by Breuillard and Varjú to study the $ax+b$ process, which show equidistribution for $f(α)$ at a single point. We extend this to handle multiple roots and the Hasse derivatives of $f$, which allow us to study the irreducible factors with multiplicity.
description: v2: updated introduction, 34 pages, 4 figures. Comments are welcome!
Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN
Creators: name: Ratliff, Lyndsay A.
name: Williams, Scott E.
name: Knoblich, Juergen A.
name: Fuchs, Elaine
name: Postiglione, Maria Pia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal layer progenitors to a stratified, differentiated epithelium. Morphogenesis involves perpendicular (asymmetric) divisions and the spindle orientation protein LGN, but little is known about how the apical localization of LGN is regulated. Here, we combine conventional genetics and lentiviral-mediated in vivo RNAi to explore the functions of the LGN-interacting proteins Par3, mInsc and Gαi3. Whereas loss of each gene alone leads to randomized division angles, combined loss of Gnai3 and mInsc causes a phenotype of mostly planar divisions, akin to loss of LGN. These findings lend experimental support for the hitherto untested model that Par3–mInsc and Gαi3 act cooperatively to polarize LGN and promote perpendicular divisions. Finally, we uncover a developmental switch between delamination-driven early stratification and spindle-orientation-dependent differentiation that occurs around E15, revealing a two-step mechanism underlying epidermal maturation.
[PDF] Adèle Blanc-Sec Tome 10 download
Creators: name: Turner
Publisher: name: Zenodo
Year: 2024

description: Adèle Blanc-Sec Tome 10 pan Tardi, Jean-Luc Ruault

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Caractéristiques

Adèle Blanc-Sec Tome 10

Tardi, Jean-Luc Ruault

Nb. de pages: 66

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782203252455

Editeur: Casterman

Date de parution: 2022

 

 

 

Google livres pdf téléchargement en ligne Adèle Blanc-Sec Tome 10 en francais par Tardi, Jean-Luc Ruault

 

Overview

Grâce à Honoré Fia, son illustrateur de beau-frère, Adèle échappe au poison du Docteur Chou, qui transforme son prochain en bovin écervelé. Mais elle n'est pas tirée d'affaire pour autant, puisqu'un autre danger la guette, des clones explosifs, qui lui ressemblant comme deux gouttes d'eau et se font sauter aux côtés de pontes du gouvernement lui pour faire porter le chapeau !
Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells
Creators: name: Burridge, Keith
name: Collins, Caitlin
name: Osborne, Lukas D.
name: Superfine, Richard
name: Guilluy, Christophe
name: Chen, Zhongming
name: Tzima, Ellie
name: O'Brien III, E. Tim
name: Reader, John S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Endothelial cell (ECs) lining blood vessels express many mechanosensors, including platelet endothelial cell adhesion molecule-1 (PECAM-1), that convert mechanical force to biochemical signals. While it is accepted that mechanical stresses and the mechanical properties of ECs regulate vessel health, the relationship between force and biological response remains elusive. Here we show that ECs integrate mechanical forces and extracellular matrix (ECM) cues to modulate their own mechanical properties. We demonstrate that the ECM influences EC response to tension on PECAM-1. ECs adherent on collagen display divergent stiffening and focal adhesion growth compared to ECs on fibronectin. This is due to PKA-dependent serine phosphorylation and inactivation of RhoA. PKA signaling regulates focal adhesion dynamics and EC compliance in response to shear stress in vitro and in vivo. Our study identifies a ECM-specific, mechanosensitive signaling pathway that regulates EC compliance and may serve as an atheroprotective mechanism maintains blood vessel integrity in vivo.
Vascular channels formed by subpopulations of PECAM1+ melanoma cells
Creators: name: Thompson, Joshua
name: Dayton, Paul A.
name: Melero-Martin, Juan M.
name: Dunleavey, James M.
name: Irvin, David M.
name: Brings, Victoria E.
name: Kim, Mi Mi
name: Ollila, David W.
name: Shelton, Sarah E.
name: Xiao, Lin
name: Dudley, Andrew C.
name: Brekken, Rolf A.
name: Shields, Janiel M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Targeting the vasculature remains a promising approach for treating solid tumors; however, the mechanisms of tumor neovascularization are diverse and complex. Here we uncover a new subpopulation of melanoma cells that express the vascular cell adhesion molecule PECAM1, but not VEGFR-2, and participate in a PECAM1-dependent form of vasculogenic mimicry (VM). Clonally-derived PECAM1+ tumor cells coalesce to form PECAM1-dependent networks in vitro and they generate well-perfused, VEGF-independent channels in mice. The neural crest specifier AP-2α is diminished in PECAM1+ melanoma cells and is a transcriptional repressor of PECAM1. Reintroduction of AP-2α into PECAM1+ tumor cells represses PECAM1 and abolishes tube-forming ability whereas AP-2α knockdown in PECAM1− tumor cells up-regulates PECAM1 expression and promotes tube formation. Thus, VM-competent subpopulations, rather than all cells within a tumor, may instigate VM, supplant host-derived endothelium, and form PECAM1-dependent conduits that are not diminished by neutralizing VEGF.
A quantitative description of Ndc80 complex linkage to human kinetochores
Creators: name: Salmon, Edward D.
name: Badger, Benjamin L.
name: Suzuki, Aussie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The Ndc80 complex, which mediates end-on attachment of spindle microtubules, is linked to centromeric chromatin in human cells by two inner kinetochore proteins, CENP-T and CENP-C. Here to quantify their relative contributions to Ndc80 recruitment, we combine measurements of kinetochore protein copy number with selective protein depletion assays. This approach reveals about 244 Ndc80 complexes per human kinetochore (∼14 per kinetochore microtubule), 215 CENP-C, 72 CENP-T and only 151 Ndc80s as part of the KMN protein network (1:1:1 Knl1, Mis12 and Ndc80 complexes). Each CENP-T molecule recruits ∼2 Ndc80 complexes; one as part of a KMN network. In contrast, ∼40% of CENP-C recruits only a KMN network. Replacing the CENP-C domain that binds KMN with the CENP-T domain that recruits both an Ndc80 complex and KMN network yielded functional kinetochores. These results provide a quantitative picture of the linkages between centromeric chromatin and the microtubule-binding Ndc80 complex at the human kinetochore.
Short-Form Videos Degrade Our Capacity to Retain Intentions: Effect of Context Switching On Prospective Memory
Creators: name: Chiossi, Francesco
name: Haliburton, Luke
name: Ou, Changkun
name: Butz, Andreas
name: Schmidt, Albrecht
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Social media platforms use short, highly engaging videos to catch users' attention. While the short-form video feeds popularized by TikTok are rapidly spreading to other platforms, we do not yet understand their impact on cognitive functions. We conducted a between-subjects experiment (N=60) investigating the impact of engaging with TikTok, Twitter, and YouTube while performing a Prospective Memory task (i.e., executing a previously planned action). The study required participants to remember intentions over interruptions. We found that the TikTok condition significantly degraded the users' performance in this task. As none of the other conditions (Twitter, YouTube, no activity) had a similar effect, our results indicate that the combination of short videos and rapid context-switching impairs intention recall and execution. We contribute a quantified understanding of the effect of social media feed format on Prospective Memory and outline consequences for media technology designers to not harm the users' memory and wellbeing.
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Creators: name: Hammond, Scott M.
name: Thomson, J. Michael
name: Wang, Da Zhi
name: Conlon, Frank L.
name: Chen, Jian Fu
name: Wu, Qiulian
name: Callis, Thomas E.
name: Mandel, Elizabeth M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of regulatory RNAs of ~22 nucleotides that post-transcriptionally regulate gene expression1,2. Increasing evidence points to the potential role of miRNAs in various biological processes3–8. Here we show that miRNA-1 (miR-1) and miRNA-133 (miR-133), which are clustered on the same chromosomal loci, are transcribed together in a tissue-specific manner during development. miR-1 and miR-133 have distinct roles in modulating skeletal muscle proliferation and differentiation in cultured myoblasts in vitro and in Xenopus laevis embryos in vivo. miR-1 promotes myogenesis by targeting histone deacetylase 4 (HDAC4), a transcriptional repressor of muscle gene expression. By contrast, miR-133 enhances myoblast proliferation by repressing serum response factor (SRF). Our results show that two mature miRNAs, derived from the same miRNA polycistron and transcribed together, can carry out distinct biological functions. Together, our studies suggest a molecular mechanism in which miRNAs participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development.
Descargar [PDF] {EPUB} SI FUESE MÁS VALIENTE (NOVELA GANADORA II PREMIO ELIT LGTBI)
Creators: name: Smith
Publisher: name: Zenodo
Year: 2024

description: SI FUESE MÁS VALIENTE (NOVELA GANADORA II PREMIO ELIT LGTBI) de CINTIA FERNÁNDEZ

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Ficha técnica

SI FUESE MÁS VALIENTE (NOVELA GANADORA II PREMIO ELIT LGTBI)

CINTIA FERNÁNDEZ

Número de páginas: 366

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788411803007

Editorial: HARLEQUIN IBERICA

Año de edición: 2023

 

 

 

 

 

Descargar google ebooks en formato pdf SI FUESE MÁS VALIENTE (NOVELA GANADORA II PREMIO ELIT LGTBI) (Spanish Edition)

 

Overview

Elit Lgtbi 17Ahora que por fin te has abierto, ¿te van a tratar diferente?Nico es amigo de Unai desde los seis años. Ahora, con veintidós, comparten piso en Bilbao mientras tratan de descubrir, con ayuda de sus amigas Lucía y June, cómo manejar eso de ser adultos, madurar (¡ja!) y superar a sus ex.Cuando el de Unai vuelve a entrar en escena, Nico recibe una proposición inesperada por parte de su amigo: hacerse pasar por novios para recuperar a sus antiguas parejas.Pronto, ese noviazgo falso se convierte en la historia más real de su vida. ¿O sigue? Porque ¿cuándo empezó exactamente su relación con Unai?, ¿el primer día de colegio?, ¿cuando dormían en casa del otro durante su adolescencia?, ¿o aquella noche en las fiestas del pueblo de la que nunca hablan?Dieciséis años de amistad dan para mucho, ¿qué podría salir mal?Bueno, pues… casi todo.El jurado ha dicho:"Rebosa autenticidad en cada página, desde la ambientación hasta la personalidad de sus protagonistas, las relaciones entre ellos e incluso su forma de expresarse. Es un libro que te hace sentir, emocionarte y hasta te acelera el corazón en algún momento que otro"."Unai y Nicotxu son dos personajes ficticios, pero al mismo tiempo encarnan la realidad de tal forma que, mientras leía, me sentía uno más del grupo de amigos"."La historia visibiliza la B del colectivo LGTBI, que muchas veces queda en un segundo plano incluso en las reivindicaciones"."Es una novela que plasma muy bien las dudas, el miedo, los quebraderos de cabeza y esos primeros descubrimientos que tantísimas personas han vivido"."Me ha transmitido mucha emoción, la manera de narrarlo y sus protagonistas, así como su "modus operandi"; me ha parecido muy fresco y se sale de la norma, algo que a veces puede resultar frustrante pero sin duda aquí ha dado en el clavo".