cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mycoplasma bovis and Primary Bovine Virus Diarrhea Virus Co-association in Chronic Pneumonia of Feedlot Cattle
Creators: name: Shahriar, F.
name: Clark, E. G.
name: Janzen, E.
name: West, K.
name: Wobeser, G.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Recently, multi-source feedlots in the prairie region of western Canada have experienced many cases of antibiotic resistant pneumonia, sometimes in association with multiple joint fibrinous arthritis. The lung lesions in these cases resemble those described in M. bovis infection.1 We have also observed vascular lesions, positive by immunohistochemistry for bovine virus diarrhea virus (BVDV), in the heart and lungs of some cattle. A retrospective immunohistochemical and histopathological study was done of animals of this type was submitted to the Western College of Veterinary Medicine between January 1995 and December 1998. Our objective was to determine frequency of occurrence and distribution of M. bovis, BVDV, and Haemophilus somnus in lungs and hearts of animals with lesions typical of this form of chronic pneumonia.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Herd Screening Using a Nested RT-PCR Technique to Detect Bovine Viral Diarrhea Virus (BVDV) from Pooled Buffy Coat Samples
Creators: name: Braun, Lyle
name: Peterson, Darin
name: Chase, Chris
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Bovine viral diarrhea virus (BVDV) is the leading infectious cause of abortions, stillbirths and weak calves in South Dakota. The ability to detect and identify the BVDV persistently infected animal is imperative for good herd management. There are several methods to detect BVDV in infected herds including virus isolation (VI), reverse transcriptase-polymerase chain reaction (RT-PCR) and antigen capture enzyme-linked immunosorbent assay (AC-ELISA). The microtiter test or the AC-ELISA in a multi-well tissue culture plate have been the most popular for herd screens. The RTPCR is the most sensitive assay, but due to its high cost has primarily been used as an individual test rather than a herd screening method. Dr. Kenny Brock has designed an RT-PCR to test bulk-milk samples from dairy herds. In our efforts to make RT-PCR more economically feasible as a screening assay for BVDV, we have performed several experiments involving pooled buffy coat (BC) samples.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Protocol for Identification of BVD PI Calves with Maternal Antibodies in Beef and Dairy Operations
Creators: name: Pence, Mel
name: Baldwin, Sandy
name: Hawkins, Larry
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Bovine Virus Diarrhea (BVD) virus was first recognized as a pathogen in1946, and has been implicated as the cause of one of the most widespread and economically important diseases of cattle. The importance of bovine virus diarrhea-persistently infected (BVD-PI) cattle in the spread and propagation of BVD virus has been well documented. A persistent BVD infection occurs when a fetus is exposed to the BVD virus in the first 120 days of gestation. At this stage, the developing fetal immune system recognizes the virus as part of "self", therefore, no immune response occurs. After birth, these BVD-PI cattle excrete tremendous amounts of virus from every body orifice throughout most of their lives, and thus are considered to be the most important reservoir for BVD virus. It is estimated that approximately 1% of all cattle are persistently infected.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
title: Die Entwicklung des Definitartikels im Althochdeutschen
title: Eine kognitiv-linguistische Korpusuntersuchung
titleType: Subtitle
Creators: name: Flick, Johanna
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Definitartikel
subject: Althochdeutsch
subject: kognitiv-linguistische Korpusuntersuchung
subject: 400 Sprache::410 Linguistik::410 Linguistik

description: Wie in vielen anderen Sprachen der Welt hat sich auch im Deutschen der Definitartikel aus einem adnominal gebrauchten Demonstrativum herausgebildet. In der vorliegenden Arbeit wird dieser funktionale Wandel, der sich vornehmlich in der althochdeutschen Sprachperiode (750–1050 n. Chr.) abspielte, erstmals computergestützt und mit korpuslinguistischen Methoden anhand der fünf größten ahd. Textdenkmäler aus dem Referenzkorpus Altdeutsch rekonstruiert. Dabei wird die Entwicklung des Definitartikels als Konstruktionalisierung der Struktur [dër + N] begriffen: Das ursprüngliche Demonstrativum dër verliert seine zeigende Bedeutung und erschließt neue Gebrauchskontexte, in denen die eindeutige Identifizierbarkeit des Referenten auch unabhängig von der Gesprächssituation gewährleistet ist. In der Arbeit wird gezeigt, dass diese Kontextexpansion maßgeblich von der kognitiv-linguistischen Kategorie Belebtheit beeinflusst wird.
Additional file 1 of Elucidating the need for prostate cancer risk calculators in conjunction with mpMRI in initial risk assessment before prostate biopsy at a tertiary prostate cancer center
Creators: name: Krausewitz, Philipp
name: Büttner, Thomas
name: von Danwitz, Marthe
name: Weiten, Richard
name: Cox, Alexander
name: Klümper, Niklas
name: Stein, Johannes
name: Luetkens, Julian
name: Kristiansen, Glen
name: Ritter, Manuel
name: Ellinger, Jörg
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1.
Case Control Investigation of Neospora Seroprevalence and Risk Factor Analysis for Infection and Associated Abortion in Ontario Holstein Dairy Herds
Creators: name: Hobson, J.
name: Duffield, T.
name: Peregrine, A.
name: McEwen, B.
name: Hietala, S.
name: Cramer, G.
name: Cochran, M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: In the last 10 years Neospora caninum has been identified as a major cause of abortion in dairy cattle worldwide. The objectives of this study were to characterize the impact of N. caninum infection on production and health in Ontario Holstein dairy herds and to identify possible risk factors for N. caninum serostatus and related abortions.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Additional file 1 of High cell density sequential batch fermentation for enhanced propionic acid production from glucose and glycerol/glucose mixture using Acidipropionibacterium acidipropionici
Creators: name: Dishisha, Tarek
name: Jain, Mridul
name: Hatti-Kaul, Rajni
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1. Chemical composition and organoleptic characteristics of Glycerine Tech®.
Pregnancy Diagnosis in Dairy Cows by Palpation or Ultrasound
Creators: name: Rosenbaum, Amir
name: Warnick, L. D.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Our objective was to study palpation and ultrasound pregnancy-diagnostic practices used for dairy cows by US veterinarians.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Additional file 1 of Impact of dispatcher-assisted cardiopulmonary resuscitation on neurologically intact survival in out-of-hospital cardiac arrest: a systematic review
Creators: name: Eberhard, Kristine Elisabeth
name: Linderoth, Gitte
name: Gregers, Mads Christian Tofte
name: Lippert, Freddy
name: Folke, Fredrik
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Material Table 1. Study Characteristics of Studies Excluded due to Population Overlap.
Use of Environmental Sampling as a Herd Screening Diagnostic Tool for the Detection of Mycobacterium avium Subsp paratuberculosis on Minnesota Dairy Farms
Creators: name: Raizman, E. A.
name: Wells, S. J.
name: Godden, S. M.
name: Bey, R. F.
name: Oakes, M. J.
name: Bentley, D. C.
name: Olsen, K. E.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Johne's disease (JD) is a chronic and progressive intestinal disease in ruminants caused by Mycobacterium avium subspecies paratuberculosis (Map). The usual route of infection is fecal-oral. The disease manifests in adult cows and results in economic losses. Although Map does not propagate in the environment, it survives for long periods in different environmental conditions expected on many dairy farms. Johne's disease control programs have been developed in different countries and in several US states with a goal to test and classify herds of cattle as infected or presumptively noninfected with maximum accuracy and least cost. Generally, these programs utilize recognized laboratory tests such as ELISA or direct microbiological individual fecal culture. However, these tests have several disadvantages, especially when applied in herds with subclinical disease or low prevalence. Since Map is shed into the environment by dairy cattle through fecal contamination and appears to survive well, a better understanding of Map distribution in the environment could lead to improved herd-screening alternatives. Objectives of the study were: 1) to describe Map distribution and prevalence in the environment on Minnesota dairy farms, and 2) to assess the relationship between culture status of Map in the farm environment and fecal-pooled culture status on dairy farms.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Milk Quality Premiums Received by Wisconsin Dairy Farms Participating in Veterinary-directed Milk Quality Programs
Creators: name: Ruegg, Pamela
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: High quality milk is generally defined as adulterant free milk that meets specific quality criteria relating to the level of somatic cells (SCC) and bacteria. In the U.S., production of high quality milk is encouraged by legislating maximum limits of SCC and bacteria, and by financial rewards offered by processors (premiums). This study describes the relationship between measures of milk quality, dairy management practices and financial incentives offered by milk processors on selected Wisconsin dairy farms.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Adsorption kinetics in open nanopores as a source of low-frequency noise
Creators: name: Gravelle, Simon
name: Netz, Roland R.
name: Bocquet, Lydéric
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: power spectral density
subject: 1/f noise
subject: molecular dynamics
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Ionic current measurements through solid-state nanopores consistently show a power spectral density that scales as 1/f α at low frequency f, with an exponent α ∼ 0.5–1.5, but strikingly, the physical origin of this behavior remains elusive. Here, we perform simulations of particles reversibly adsorbing at the surface of a nanopore and show that the fluctuations in the number of adsorbed particles exhibit low-frequency pink noise. We furthermore propose theoretical modeling for the time-dependent adsorption of particles on the nanopore surface for various geometries, which predicts a frequency spectrum in very good agreement with the simulation results. Altogether, our results highlight that the low-frequency noise takes its origin in the reversible adsorption of ions at the pore surface combined with the long-lasting excursions of the ions in the reservoirs. The scaling regime of the power spectrum extends down to a cutoff frequency which is far smaller than simple diffusion estimates. Using realistic values for the pore dimensions and the adsorption–desorption kinetics, this predicts the observation of pink noise for frequencies down to the hertz for a typical solid-state nanopore, in good agreement with experiments.
Diagnosis of A Novel Variant of Bovine Viral Diarrhea Virus Infection in a Bull
Creators: name: Gnad, D.
name: Debey, B.
name: Kapil, S.
name: Wilkerson, M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Bovine viral diarrhea virus BVDV is economically devastating to the beef and dairy industries in most parts of the world, and diagnosing variant strains of BVDV can challenge the practitioner. Being aware of available diagnostic tests and their limitations will aid in making an accurate diagnosis.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Additional file 2 of Impact of dispatcher-assisted cardiopulmonary resuscitation on neurologically intact survival in out-of-hospital cardiac arrest: a systematic review
Creators: name: Eberhard, Kristine Elisabeth
name: Linderoth, Gitte
name: Gregers, Mads Christian Tofte
name: Lippert, Freddy
name: Folke, Fredrik
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Cancer
subject: Science Policy

description: Additional file 2: Supplementary Material 2. DA-CPR Attempts and Barriers of Dispatcher Assistance.
NODES_INNDIANA_Z73_Injectable Nanogels for In Situ Postsurgical Treatment of Glioblastoma
Creators: name: Scomparin, Anna
Publisher: name: Zenodo
Year: 2024
Subjects: Spoke 5 - Industry for Health and Silver Economy
INNDIANA Project
Eco healthcare
ECS00000036

description: "β-cyclodextrins are interesting starting material for both in situ forming and pre-casted gels. The formulations can encapsulate drugs with different physico-chemical properties.The gel erosion and drug release can be modulated to follow the TME post-surgical remodelling. The obtained gel will be tested in clinically relevant models and settings: tumor maximal safe resection+ local treatment + radiation."
Additional file 1 of Coupling of nanostraws with diverse physicochemical perforation strategies for intracellular DNA delivery
Creators: name: Jiang, Juan
name: Liu, Jing
name: Liu, Xinmin
name: Xu, Xingyuan
name: Liu, Zhengjie
name: Huang, Shuang
name: Huang, Xinshuo
name: Yao, Chuanjie
name: Wang, Xiafeng
name: Chen, Yixin
name: Chen, Hui-jiuan
name: Wang, Ji
name: Xie, Xi
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Supplementary Material 1
And now, the Bad News
Creators: name: Van Campen, Hana
name: Huzurbazar, Snehalata
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Bovine viral diarrhea virus (BVDV) is the most common infectious cause of abortions, stillbirths and weak calves in western range beef herds. A variety of vaccines containing a BVDV component are used by producers to prevent the consequences of fetal BVDV infections. In spite of vaccination, BVDV "wrecks" occur annually. This study examined the impact of BVD-associated disease in vaccinated beef herds.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Periparturient N eutrophil Function Suppression is Associated with Endornetritis and Fever in Lactating Dairy Cows
Creators: name: Hammon, D. S.
name: Evjen, I. M.
name: Goff, J. P.
name: Dhiman, T. R.
name: Walters, J. L.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Endometritis and fever are common health disorders that affect dairy cows during the immediate postparturient period and are temporally associated with periparturient immune suppression. The aim of this study was to test the hypothesis that endometritis and fever in dairy cows are associated with suppressed neutrophil functions during the periparturient period.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Evaluation of Rectal Temperature and Calving Related Factors on the Incidence of Metritis in Postpartum Dairy Cows
Creators: name: Benzaquen, M. E.
name: Risco, C.
name: Archbald, L. F.
name: Thatcher, M. J.
name: Thatcher, W. W.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Metritis is a serious condition in dairy cows since it affects production, fertility and can be life-threatening. A better understanding of calving-related factors that predispose cows to metritis would aid in prevention, diagnosis and treatment of this condition. The objectives of this study were to: 1) evaluate the association of calving status, parity and season on the incidence of postpartum metritis in lactating dairy cows; 2) examine the role of rectal temperature as a predictor of this condition; and 3) document the effect of metritis on subsequent reproductive performance.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Canadian Leadership in RDM: Portage Partnerships & Progress
Creators: name: Moon, Jeff
Publisher: name: Zenodo
Year: 2019
Subjects: subject: college
subject: post-secondary institute
subject: canada
subject: polytechnic
subject: tri-agency policy
subject: https://dictionary.casrai.org/Research_data_management
subject: https://dictionary.casrai.org/Data_management
subject: https://dictionary.casrai.org/Open_data

description: Presentation on the CARL Portage Network for the Canadian Colleges, Institutes & Polytechnics Research Data Management Workshop.
Use of Eosin Methylene Blue Agar to Differentiate Escherichia coli from other Gram-negative Mastitis Pathogens
Creators: name: Leininger, Dagny J.
name: Roberson, Jerry R.
name: Elvinger, François
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Mastitis is a continuous concern for dairy producers in the US because of its economic consequences. Coliform mastitis accounts for 20% to 80% of acute clinical mastitis cases and includes gram-negative pathogens Escherichia coli, Klebsiella and Enterobacter species. Rapid identification of the causative organism is essential to implement a prudent treatment plan. Escherichia coli can be rapidly identified with eosin methylene blue (EMB) agar based on the occurrence of a green-metallic sheen that appears on the surface of the bacterial colonies. The primary goal of this study was to evaluate EMB agar for differentiation of E. coli from other gram-negative mastitis pathogens. The secondary goal was to determine the time to first visible sheen.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Exploring Human-Virtual agent Collaboration for layout design in VR
Creators: name: Jimenez, Angela Liliana
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 460708
subject: Virtual and mixed reality
classificationCode: 460702
subject: Computer graphics
classificationCode: 460799
subject: Graphics, augmented reality and games not elsewhere classified

description: This thesis explores human-virtual agent collaboration for layout design in a virtual reality environment. Specifically, we developed a human-in-the-loop optimization-based method that allows the decision-making of the virtual agent. Our algorithm accounts for spatial constraints in furniture placement by evaluating wall proximity, collision costs, and relationships between furniture items. It also considers the current configuration of the living room, whether modified by the virtual agent or the user during the co-design process, to guide the virtual agent’s furniture items placement decisions in the virtual living room environment. We compared our method (i.e., optimization-based) against two other co-design strategies (i.e., template-based and random-based) following a within-group (N = 24) study design. We found the optimization-based approach significantly enhanced perceived collaboration compared to template-based and random-based methods. Moreover, our participants attributed higher private and public awareness to the optimization-based virtual agent. Our analyses of user activity logged data revealed that participants placed more furniture items and made fewer corrections to virtual agent placements in the optimization-based condition. Our findings demonstrate that adaptive virtual agent behavior that dynamically responds to user actions while maintaining spatial coherence created more effective collaborative experiences in immersive design environments.
Accurate Diagnosis of the Mycobacterium paratuberculosis Status of Cattle Herds
Creators: name: Smith, David R.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Programs to classify cattle herds by M. paratuberculosis infection status must satisfy buyer's concerns that cattle from tested herds are unlikely to be infected (high negative predictive value), and seller's concerns that their herds will not be erroneously, classified as infected (high positive predictive value). Veterinarians recommending these programs need confidence that a high percentage of herds will be classified correctly. Probablistic models were used to evaluate 3 diagnostic strategies that use tests of individuals to classify cattle herds by M. paratuberculosis infection status: 1) enzyme-linked immunosorbent assay (ELISA) serology; 2) culture of feces; 3) ELISA serology in series with confirmatory culture of feces.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Tri-Agency Research Data Management Policy Development
Creators: name: Fitzgibbons, Kevin
Publisher: name: Zenodo
Year: 2019
Subjects: subject: college
subject: post-secondary institute
subject: canada
subject: polytechnic
subject: tri-agency policy
subject: https://dictionary.casrai.org/Research_data_management
subject: https://dictionary.casrai.org/Data_management
subject: https://dictionary.casrai.org/Open_data

description: Presentation on the Tri-Agency Research Data Management Policy for the Canadian Colleges, Institutes & Polytechnics Research Data Management Workshop.
Additional file 1 of Clinical characteristics of Gram-negative and Gram-positive bacterial infection in acute cholangitis: a retrospective observational study
Creators: name: Tian, Shijing
name: Li, Kaili
name: Tang, Hong
name: Peng, Yan
name: Xia, Liang
name: Wang, Xi
name: Chen, Xiaoying
name: Zhou, Fachun
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Risk ratio of organ dysfunction in different culture results by logistic-regression model.
Using Indices of Cow Comfort to Predict Stall Use and Lameness
Creators: name: Cook, N. B.
name: Bennett, T. B.
name: Nordlund, K. V.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: The objective of this study was to measure several indices of cow comfort for one 24- hour period in the high-group pens of a selection of Wisconsin dairy herds using either sand or rubber-crumb-mattress surface free stalls, and to determine the most appropriate time of day for measurement in terms of their ability to predict cow behavior and lameness prevalence.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Additional file 1 of Development of indicators and moral intelligence scales for junior high school students: mixed-method research
Creators: name: Prasertsin, Ujsara
name: Srihaset, Kamontip
name: Roopsuwankun, Pattama
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Application of phagemid-AAV vector in gene therapy of paediatric brain cancer
Creators: name: Albahrani, Mariam
Publisher: name: Imperial College London
Year: 2018

description: Medulloblastoma and Diffuse intrinsic pontine glioma (DIPG) are childhood brain tumours with high malignancy, the former being the most common and the latter is the most aggressive. Although medulloblastoma patients have a high likelihood of long-term survival after conventional treatment, the prognosis is unfavourable and the treatment options result in long-term neurologic side effects. On the other hand, DIPG patients have a poor survival rate of only 6-10% beyond two years with no effective therapies. Thus, the development of novel, safer and effective therapeutic strategies, or improvement of existing treatments are urgently needed. Gene therapy is an attractive field for the treatment of cancer and offers potential to overcome the limitations of current therapeutic strategies. Here we applied a targeted cytokine gene therapy by using an engineered hybrid adeno-associated phagemid-based vector (PAAV) to selectively target the tumour through cancer-selective integrin binding ligand. PAAV bacteriophage is genetically engineered to express the RGD4C peptide on the vector capsid to ensure targeting of tumour cells and tumour vasculature through binding to α_v β_3 integrin receptor that is overexpressed in tumours and absent or barely detectable in the healthy tissues. In this study, we investigated the efficacy of this targeted vector (RGD4C/PAAV) as a gene delivery vehicle for medulloblastoma and DIPG. The tumour necrosis factor (TNFα) was used as the cytokine therapeutic gene to be delivered and expressed in the tumour cells. This prototype (RGD4C/PAAV-TNFα) induced cell death and activated the caspase pathway in DIPG. This targeted delivery of TNFα was also investigated in medulloblastoma cells in vitro, using UW228 and Daoy medulloblastoma cell lines, and showed high efficacy in inducing cell death. This effect was further augmented by using low dose cisplatin. Moreover, we showed that cisplatin induced the activity of GRP78 and CMV promoters and boosted transgene expression by RGD4C/PAAV in both medulloblastoma and DIPG cells. Finally, the efficacy of our prototype was tested for the treatment of medulloblastoma in vivo through intravenous administration. RGD4C/PAAV- TNFα showed high a and selective tumour homing resulting in targeted TNFα transgene delivery to the tumours. Beside the induction of tumour cell death, this treatment strategy induced damage to the tumour-associated blood vessels, in vivo. TNFα cytokine has long been known to possess anti-tumour activity but also has high systemic toxicity limiting its use in the clinic. In this thesis, we demonstrated that the use of RGD4C/PAAV provides a solution to this problem by targeting TNFα expression selectively to the tumour environment, ensuring systemic safety and therapeutic efficacy for the treatment of childhood brain tumours.
Comparison of Dairy Cow Behavior in Sand and Mattress Freestall Barns in Relation to Lameness
Creators: name: Cook, N. B.
name: Bennett, T. B.
name: Nordlund, K. V.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: The objective of the study was to identify behavioral differences between cows housed in freestalls bedded with deep sand and cows housed in freestalls with rubber crumb mattresses, which may explain differences in lameness prevalence observed between the two types of farm.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Pregnancy Diagnosis by Rectal Palpation in Dairy Cows
Creators: name: Warnick, L. D.
name: See, S. Y.
name: Rosenbaum, A.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Pregnancy diagnosis by rectal palpation is one of the most frequent procedures performed by dairy veterinarians, but very little is known about the economically optimal schedule for palpation. In a practitioner survey, 34 days was the median response for how soon after breeding veterinarians reported routinely palpating cows (see companion abstract). Previous research showed that cows checked later in gestation were more likely to stay in the herd and calve again, but those studies did not address the optimal herd-level schedule. The purpose of this study was to estimate the effect of palpation schedule on days open and culling for four pregnancy diagnosis schedules in herds using only artificial insemination for breeding.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Milk-flow Disorders
Creators: name: Querengässer, Klaus
name: Geishauser, Thomas
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: This study reviewed 133 cases of milk flow disorders in dairy cows that were diagnosed by using teat endoscopy (theloscopy).
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Holoneurini Enderlein 1936
Creators: name: Fedotova, Z. A.
name: Perkovsky, E. E.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Cecidomyiidae

description: TribeHoloneurini Enderlein, 1936 The tribe is characterized by synapomorphies characteristic of the valid tribe rank in Porricondylinae (Mamaev, 2001; Fedotova, Sidorenko, 2007): antennae with 10–11 flagellomeres; reduction of wing venation; absent or reduced parameres; tarsal claws narrow and curved near midlength; male and female flagellomeres with dense sensorial reticulation, and female flagellomeres with a long neck. Their wing venation is variable, with M 3 absent or slightly visible, Cu never forked, CuA 2 slightly visible distally or completely disappearing, m+rm usually slightly curved distally, and rs situated at an angle to R 5. The ovipositor is 2-segmented. The larvae of some extant species of the Holoneurini have been associated with leaf litter and decaying wood (Mamaev, Krivosheina, 1965). Adult insects are usually captured in Malaise traps (Fedotova, Sidorenko, 2005, 2007). The tribe includes 12 genera and 43 species: 9 extant genera with 38 species (number of species in parentheses): Cassidoides Mamaev, 1960 (8); Coccopsis Meijere, 1901 (8); Cognitepidosis Fedotova et Sidorenko, 2005 (1); Cryptoneurus Mamaev, 1964 (3); Dalaiella Mamaev, 1996 (1); Holoneurus Kieffer, 1894 (14), Melicepidosis Fedotova et Sidorenko, 2007 (1); Putepidosis Fedotova et Sidorenko, 2007 (1), Pyxicoccopsis Fedotova et Sidorenko, 2007 (1) and 3 extinct genera with 5 species: Gratomyia (1), Volnococcopsis (1) and Rovnoholoneurus gen. n. (3).
description: Published as part of Fedotova, Z. A. & Perkovsky, E. E., 2017, New Genus And Species Of Gall Midges (Diptera, Cecidomyiidae: Porricondyinae, Holoneurini) From The Late Eocene Amber Of Olevsk (Zhitomir Region, Ukraine), pp. 23-30 in Vestnik Zoologii (Vestn. Zool.) (Vestn. Zool.) 51 (1) on page 24, DOI: 10.1515/vzoo-2017-0004, http://zenodo.org/record/6454042
description: {"references": ["Mamaev, B. M. 2001. The tribe Holoneurini in the Palearctic (Diptera, Cecidomyiidae). All-Russian Institute of Continuous Education in Forestry, Pushkino, 17, 1 - 11 [In Russian].", "Fedotova, Z. A., Sidorenko, V. S. 2007. New taxa of gall midges (Diptera, Cecidomyiidae, Porricondylinae) with reduced wing venation and flagellomeres from Russia. An International Journal of Dipterological Research, 18 (4), 235 - 277.", "Mamaev, B. M., Krivosheina, N. P. 1965. Larvae of gall midges (Diptera, Cecidomyiidae). Comparative morphology, Biology and keys. Nauka, Moskow, 1 - 278 [In Russian].", "Fedotova, Z. A., Sidorenko, V. S. 2005. New species of gall midges of the subfamily Porricondylinae from the Russian Far East (Diptera, Cecidomyiidae). An International Journal of Dipterological Research, 16 (2), 89 - 127."]}
Evaluation of the California Mastitis Test for Screening Dairy Cows for Intramammary Infection at Calving
Creators: name: Sargeant, J. M.
name: Leslie, K. E.
name: Shirley, J. E.
name: Sheffel, M. E.
name: Lim, G. H.
name: Pulkrabek, B. J.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Udder health management programs at dry-off and during the dry period are essential to control and prevention of mastitis in dairy cattle. Knowledge of the prevalence of subclinical intramammary infection status at calving, and the specific pathogens involved, allows producers to evaluate effectiveness of these udder health programs. However, milk sampling and culturing all cows at the time of calving can be expensive and time consuming, and has not been widely adopted by the industry. California mastitis test (CMT) has not been recommended for use in recently fresh cows. This study examined the use of the CMT for selecting quarters in fresh cows for further bacteriological examination to identify the presence of intramammary infection. Cut-points for defining a positive CMT test and length of time post-calving were evaluated.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Efficacy of an Internal Teat Sealant, Orbeseal, for Reduction of Clinical Mastitis during the First 60 Days Post-partum
Creators: name: Sanford, C.
name: Keefe, G.
name: Dohoo, I.
name: Leslie, K.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Clinical mastitis (CM) events often occur during the post-partum period and are important economically. Many CM cases result from infections that have been established during the dry period. In one study, 38.1% of clinical cases had the same bacteria isolated at some point during the dry period.4 Risk factors for development of new intramammary infections (IMI) in the dry period have been reviewed.2 Among the risk factors identified was failure to develop a natural keratin seal in 23.4% of teats.2 These open quarters were 1.8 times more likely to develop a new intramammary infection (IMI). Efficacy of the internal teat sealant, OrbeSeal* (OS) for prevention of new IMis during the dry period has been well established.1,3,5-7 The objective of this study was to evaluate the efficacy of OS infused at dry-off for the reduction of new cases of CM during the first 60 days of lactation, as compared to routine intramammary dry cow antibiotic therapy (DCT).
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Additional file 1 of Identification of immunization-related new prognostic biomarkers for papillary renal cell carcinoma by integrated bioinformatics analysis
Creators: name: Wu, Ping
name: Xiang, Tingting
name: Wang, Jing
name: Lv, Run
name: Ma, Shaoxin
name: Yuan, Limei
name: Wu, Guangzhen
name: Che, Xiangyu
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. DEGs of KIRP in GSE11151 downloaded from the GEO dataset, including 19 pRCC samples and five normal samples. Table S2. DEGs of KIRP in GSE15641 downloaded from the GEOdataset, containing 11 pRCC samples and 23 normal samples. Table S3. DEGs between pRCC and normal kidney tissue inTCGA database screened through the GEPIA website. Table S4. 32normal kidney tissues samples and 271tumor samples downloaded from TCGA GDC data portal.
Additional file 1 of Modelling the impact of human behavior using a two-layer Watts-Strogatz network for transmission and control of Mpox
Creators: name: Jia, Qiaojuan
name: Xue, Ling
name: Sui, Ran
name: Huo, Junqi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Materials 1.
Antimicrobial Treatment Strategies for Streptococcal and Staphylococcal Mastitis
Creators: name: Crandall, K. D.
name: Guterbock, W. M.
name: Sears, P. M.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2004

description: Mastitis is one of the most costly diseases encountered by a dairyman. Traditional therapy aimed at curing clinical mastitis cases includes intramammary (IMM) antimicrobial therapy. Most, if not all, commercially available IMM antimicrobial products are effective only against gram-positive organisms, mainly streptococcal and staphylococcal species. In spite of multiple available IMM antimicrobial products, cure rates for clinical mastitis run about 46% for strep species, 21 % for staph species, and 9% for Staphylococcus aureus mastitis. This study investigated the use of systemic antimicrobial therapy (ampicillin) in conjunction with IMM antimicrobial therapy for strep species., staph species., and S. aureus on a commercial dairy.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2004
Acute Interstitial Pneumonia in Feedlot Cattle
Creators: name: Loneragan, Guy H.
name: Gould, Daniel H.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Acute interstitial pneumonia (AIP) is a descriptive term for a specific histopathological pattern, including hyaline membrane formation, and proliferation of type II alveolar epithelial cells.6,18 Other lesions often identified are interlobular edema, hemorrhage and vascular congestion. The condition occurs secondary to alveolar wall damage resulting in transudation of relatively acellular, and fibrinogen-rich fluid into alveolar spaces and terminal airways.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Additional file 1 of Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019
Creators: name: Li, Zhen
name: Ma, Xudong
name: Gao, Sifa
name: Li, Qi
name: Luo, Hongbo
name: Sun, Jianhua
name: Du, Wei
name: Su, Longxiang
name: Wang, Lu
name: Zhang, Qing
name: Li, Zunzhu
name: Zhou, Xiang
name: Liu, Dawei
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Definition of ventilator-associated pneumonia, catheter-related bloodstream infections, and catheter-associated urinary tract infections.
Salmonellosis in Feed Yards
Creators: name: Hawkins, Larry L.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Since the advent of the germ theory in the late 1800's and George Soper's10 discovery of the link the between Mary Mallon's employment history and 7 cases of typhoid fever in early 1907, salmonellosis has presented a diagnostic and clinical challenge to medical practitioners. Salmonellosis is caused by gram-negative, rod-shaped, facultative anaerobic, intracellular bacteria of the family Enterobacteriaceae, genus Salmonella.12 There are at least 2300 serotypes (serovars) of Salmonella based on their somatic or O antigens (lipopolysaccharides or endotoxins), flagellar or H antigens, and in some cases virulence or Vi antigens. There is debate as to whether these serovars are distinct species or are a subspecies of one species, S. enterica, but most often serovars are considered species. Most of the serovars of Salmonella are potential pathogens, but approximately 15 are commonly identified in diseased animals. Some Salmonellae are host specific, such as S. choleraesuis in swine, S. typhi in people8 and S. abortus-ovis in sheep. In contrast others, such as S. typhimurium, infect cattle, sheep, goats, swine, horses, poultry, rodents, people, and occasionally dogs and cats.22 Salmonellosis is a serious zoonotic disease1 (CDC reported 41,901 cases in people in 1997)11 and is estimated to cost $0.6 to 3.5 billion23 in medical expenditures and lost production in the U.S. annually. Consequently, educating clients and their employees about the zoonotic hazards of working with animals during a Salmonella outbreak is as important as treating the animals. Salmonellosis is extremely important to all of the food animal industries because their products are common sources of Salmonella for people.1
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000
Rovnoholoneurus davidi Fedotova et Perkovsky 2017, sp. n.
Creators: name: Fedotova, Z. A.
name: Perkovsky, E. E.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Cecidomyiidae
Rovnoholoneurus
Rovnoholoneurus davidi

description: Rovnoholoneurus davidi Fedotova et Perkovsky, sp. n. urn:lsid:zoobank.org:act: 70FAF245-2E6C-4403-81C2-CEB16E6512EF M a t e r i a l. Holotype. SIZK OL-8, a well-preserved male with partly missing tarsi from Olevsk, Rovno amber; Late Eocene. Syninclusions: SIZK OL-7, Carabidae, Psychodidae; SIZK OL-8, Chironomidae, Tipuloidea, Acari; SIZK OL-9, 2 Sciaridae, Psychodidae, Tipuloidea, Chironomidae (Orthocladiinae), Cecidomyiidae, Collembola (Symphypleona), Acari; SIZK OL-10, 2 Trichoptera, 18 Diptera (4 Sciaridae, 11 Chironomidae (Orthocladiinae), 2 Cecidomyiidae, Nematocera indet.). D e s c r i p t i o n. Male (fig. 1, 1 –6, 2, 1–11). Body 1.2 times as long as antenna, wing 1.3 times as long as body. Wing 1.5 times as long as antenna. 1st flagellomere 1.3 times as long as 2nd; proximal flagellomeres with long neck, almost as long as basal enlargement; 2nd flagellomere slightly shorter than 1st; distal flagellomeres with short neck; 5th flagellomere 3.8 times as long as wide; 11th flagellomere conical, 1.6 times as long as 10th. Palpi slightly longer than head, very narrow, parallel sided. Wing 3.5 times as long as wide. Vein R 1+2 is 2.2 times shorter than wing. Profemora and metafemora shorter than corresponding tibia; mesofemur longer than mesotibia. Genitalia transverse; gonostylus short, narrow. M e a s u r e m e n t s (mm): body length, 1.43; antennal length, 1.23; head length with mouth part, 0.31; head length without mouth part, 0.26; head height, 0.21; thorax length, 0.54; thorax width, 0.38; abdomen length, 0.93; wing length, 1.84; wing width, 0.52; vein R 1+2 , 0.85; length of fore leg 1.88: coxa, 0.10; trochanter, 0.07; femur, 0.69; tibia, 0.79; fore tarsi, 1.44; length of middle leg: coxa, 0.11; trochanter, 0.07; femur, 0.61; tibia, 0.57; 1st tarsal segment 0.08; 2nd 0.79; 3rd 0.38; 4th 0.16; 5th 0.11; middle tarsi, 1.52 and leg, 2.88; length of hind leg: coxa, 0.10; trochanter, 0.07; femur, 0.52; tibia, 0.66; 1st tarsal segment, 0.11; 2nd 0.67; 3rd 0.33; 4th 0.15; 5th 0.12; hind tarsi, 1.41 and leg, 3.14. E t y m o l o g y. The species is named after David, the son of the junior author.
description: Published as part of Fedotova, Z. A. & Perkovsky, E. E., 2017, New Genus And Species Of Gall Midges (Diptera, Cecidomyiidae: Porricondyinae, Holoneurini) From The Late Eocene Amber Of Olevsk (Zhitomir Region, Ukraine), pp. 23-30 in Vestnik Zoologii (Vestn. Zool.) (Vestn. Zool.) 51 (1) on page 27, DOI: 10.1515/vzoo-2017-0004, http://zenodo.org/record/6454042
MOESM1 of Pulmonary infections prime the development of subsequent ICU-acquired pneumonia in septic shock
Creators: name: Llitjos, Jean-François
name: Gassama, Aïcha
name: Charpentier, Julien
name: Lambert, Jérôme
name: Roquetaillade, Charles
name: Cariou, Alain
name: Chiche, Jean-Daniel
name: Mira, Jean-Paul
name: Jamme, Matthieu
name: Pène, Frédéric
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Flowchart of the study. ICU: intensive care unit.
Additional file 1 of Screening and staging of chronic obstructive pulmonary disease with deep learning based on chest X-ray images and clinical parameters
Creators: name: Zou, XiaoLing
name: Ren, Yong
name: Yang, HaiLing
name: Zou, ManMan
name: Meng, Ping
name: Zhang, LiYi
name: Gong, MingJuan
name: Ding, WenWen
name: Han, LanQing
name: Zhang, TianTuo
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Supplementary Material 1
Surgical and Anesthetic Procedures Performed in Bovine Practice and Proficiency Expected of New Veterinary Graduates
Creators: name: Morin, Dawn E.
name: Constable, Peter D.
name: Johnson, Ann L.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2000

description: Bovine practice is perceived to be changing, with the emphasis shifting from diagnosis and treatment of disease in individual animals toward enhanced production and disease prevention in herds. Therefore, faculty members at veterinary colleges must periodically ascertain the most relevant procedures and skills for veterinarians entering bovine practice, and adjust curricula accordingly. Of particular concern is ensuring that new graduates are proficient in surgical and anesthetic procedures deemed most important by practitioners, given declining case loads at most teaching hospitals and attempts to find alternatives to live animal surgical laboratories. To assist with curriculum adjustment at the University of Illinois, a mail survey was conducted to determine procedures performed most frequently in bovine practice, and skills expected of new veterinary graduates.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2000