cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The orthosymplectic supergroup in harmonic analysis
Creators: name: Coulembier, Kevin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Representation Theory (math.RT)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 17B10, 58C50, 17B15

description: The orthosymplectic supergroup OSp(m|2n) is introduced as the supergroup of isometries of flat Riemannian superspace R^{m|2n} which stabilize the origin. It also corresponds to the supergroup of isometries of the supersphere S^{m-1|2n}. The Laplace operator and norm squared on R^{m|2n}, which generate sl(2), are orthosymplectically invariant, therefore we obtain the Howe dual pair (osp(m|2n),sl(2)). This Howe dual pair solves the problems of the dual pair (SO(m)xSp(2n),sl(2)), considered in previous papers. In particular we characterize the invariant functions on flat Riemannian superspace and show that the integration over the supersphere is uniquely defined by its orthosymplectic invariance. The supersphere manifold is also introduced in a mathematically rigorous way. Finally we study the representations of osp(m|2n) on spherical harmonics. This corresponds to the decomposition of the supersymmetric tensor space of the m|2n-dimensional super vectorspace under the action of sl(2)xosp(m|2n). As a side result we obtain information about the irreducible osp(m|2n)-representations L_{(k,0,...,0)}^{m|2n}. In particular we find branching rules with respect to osp(m-1|2n).
A proteomics and bioinformatics study of peptides in the human immunopeptidome
Creators: name: MEI, SHUTAO
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified
classificationCode: 310803
subject: Plant cell and molecular biology
classificationCode: 310902
subject: Animal cell and molecular biology

description: The presentation of protein degraded peptides by human leukocyte antigen class I (HLA-I) molecules forms the basis of the CD8+ T cell mediated immune response. However, current knowledge on how factors can determine peptide’s immunogenicity remains to be explored. This thesis has focused on two significant factors post-translational modification (PTM) as well as binding between peptide and HLA-I. The outcome has revealed that a predominant of HLA-I bound peptides bearing asparagine deamidation, one type of PTM, is associated with N-glycosylated precursors and potentially being utilized by the immune system for monitoring aberrant glycosylation. Additionally, tools for the prediction ofHLA-I peptide binding has been extensively reviewed and evaluated for guiding researchers to select most suitable predictors. Finally, a new tool with the model customisation function has been developed to solve the current limitation and to facilitate the development of immunotherapy.
Quantized Charge Pumping through a Carbon Nanotube Double Quantum Dot
Creators: name: Chorley, S. J.
name: Frake, J.
name: Smith, C. G.
name: Jones, G. A. C.
name: Buitelaar, M. R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate single-electron pumping in a gate-defined carbon nanotube double quantum dot. By periodic modulation of the potentials of the two quantum dots we move the system around charge triple points and transport exactly one electron or hole per cycle. We investigate the pumping as a function of the modulation frequency and amplitude and observe good current quantization up to frequencies of 18 MHz where rectification effects cause the mechanism to break down.
Identification of cancer specific endogenous HLA class I peptide repertoire in haematological and paediatric brain malignancy
Creators: name: PANDEY, KIRTI
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 320409
subject: Tumour immunology

description: Using a combination of high-resolution mass spectrometry (MS) flow cytometry, and other biochemical techniques the study investigates in-depth the immunopeptidome of AML including cell lines and clinical samples. the thesis also thoroughly investigates the immunopeptidome of DIPG, a type of rare and aggressive paediatric glioma. Through our optimised MS workflow, we have identified different peptides which have the potential of being translated at a clinical level for T cell mediated immunotherapy, hence fulfilling the unmet need for DIPG specific treatment.
Cas9-based local enrichment and genomics sequence revision of megabase-size Shark immunoglobulin new antigen receptor loci
Creators: name: 东红明(Donghongming)
Publisher: name: CNGB
Year: 2021
Subjects: Genome sequencing and assembly
Raw sequence reads
Targeted Locus (Loci)
Monoisolate
Other
Immunogenetics

description: The 0.8 Mb immunoglobulin new antigen receptor (IgNAR) region of the whitespotted bamboo shark (Chiloscyllium plagiosum) is incompletely assembled in Chr_44 of the reference genome. Here we used Cas9-assisted targeting of chromosome segments (CATCH) to enrich the 2 M region of the Chr_44 IgNAR loci and sequenced by PacBio and next-generation sequencing (NGS). A fragment larger than 3.13 M was isolated intact from the red blood cells of sharks. The target was enriched 245.531-fold, and sequences had up to 94% coverage with a 255 × mean depth. Compared to the previously published sequences, 20 holes were filled, with a total length of 3508 bp. In addition, we report five potential germline V alleles of IgNAR1 from six sharks that may belong to two clusters of the IgNAR. Our results provide a new method to research the germline of large immunoglobulin gene segments, as well as provide the enhanced bamboo shark IgNAR gene loci with fewer gaps.
Clinical Evaluation of a Metagenomics-based Assay for Pneumonia Management
Creators: name: 何福生(Fushenghe)
Publisher: name: CNGB
Year: 2021
Subjects: Metagenome
Multispecies
Other
Clinical pathogen diagnosis

description: Clinical value of metagenomic next-generation sequencing (mNGS) in pneumonia management is still controversial. A prospective study was conducted to evaluate the clinical impact of PneumoSeq in 57 immunocompetent (ICO) and 75 immunocompromised (ICH) pneumonia patients. The value of PneumoSeq for both etiological and clinical impact investigation in pneumonia was assessed. Among the 276 potential pathogens detected with PneumoSeq in our cohort, 251 (90.9%) were cross-validated. Clinical diagnoses of the causative pathogens were obtained for 97 patients, 90.7% of which were supported by PneumoSeq. Compared to conventional testing, PneumoSeq suggested potentially missed diagnoses in 16.7% of cases (22/132), involving 48 additional pathogenic microorganisms. In 58 (43.9%) cases, PneumoSeq data led to antimicrobial treatment de-escalation (n=12 in ICO, n=18 in ICH) and targeted treatment initiation (n=7 in ICO, n=21 in ICH). The PneumoSeq assay benefited the diagnosis and clinical management of both ICH and ICO pneumonia patients in real-world settings.
Characterization of ACA-01 a Chemokine-Binding Tick Evasin
Creators: name: CHOWDHURY, SAYEEDA TASNEEM
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 340407
subject: Proteins and peptides
classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310101
subject: Analytical biochemistry

description: The complexity of the chemokine-receptor interaction network makes it difficult to engineer targeted drug therapy. Ticks have the solution to this complexity. As a strategy to suppress the inflammatory responses of their mammalian hosts and thereby prolong their feeding and residence times, ticks have evolved the ability to produce salivary proteins, known as Evasins, which bind to host chemokines, blocking activation of chemokine receptors and preventing leukocyte migration. ACA-01 is an Evasin found in the tick species Amblyomma cajanennense. We aimed to establish that ACA-01 is a chemokine-binding protein and solve its crystal structure. We report binding of ACA-01 to a panel of six CC chemokines using a Fluorescence Anisotropy (FA) assay. After crystallization trials, we successfully obtained needles of ACA-01 protein crystals. These studies will establish a foundation for developing ACA-01 as a potential anti-inflammatory therapeutic.
Józef Sperling (1884–1949) – przedsiębiorca i innowator
Creators: name: Łomnicka, Katarzyna
Publisher: name: Pamiętnik Sztuk Pięknych / Fine Arts Diary
Year: 2019

description: Pamiętnik Sztuk Pięknych / Fine Arts Diary, Bd. 10 (2015): Pamiętnik Sztuk Pięknych / Fine Arts Diary
Measurement of relative branching fractions of B decays to $ψ(2S)$ and $J/ψ$ mesons
Creators: name: LHCb Collaboration
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The relative rates of B-meson decays into $J/ψ$ and $ψ(2S)$ mesons are measured for the three decay modes in pp collisions recorded with the LHCb detector. The ratios of branching fractions ($\mathcal{B}$) are measured to be $\frac{\mathcal{B}(B^+ \to ψ(2S) K^+)}{\mathcal{B}(B^+ \to J/ψK^+)} = 0.594 \pm 0.006 (stat) \pm 0.016 (syst) \pm 0.015 (R_ψ)$, $\frac{\mathcal{B}(B^0 \to ψ(2S) K^{*0})}{\mathcal{B}(B^0 \to J/ψK^{*0})} = 0.476 \pm 0.014 (stat) \pm 0.010 (syst) \pm 0.012\,(R_ψ)$, $\frac{\mathcal{B}^{0}_{s}(B^0_s \to ψ(2S)ϕ)}{\mathcal{B}(B^0_s \to J/ψϕ)} = 0.489 \pm 0.026 (stat) \pm 0.021 (syst) \pm 0.012\,(R_ψ)$ where the third uncertainty is from the ratio of the $ψ(2S)$ and $J/ψ$ branching fractions to $μμ$.
description: 14 pages, 1 figure
Gaussian Post-selection for Continuous Variable Quantum Cryptography
Creators: name: Walk, Nathan
name: Symul, Thomas
name: Lam, Ping Koy
name: Ralph, Timothy C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We extend the security proof for continuous variable quantum key distribution protocols using post selection to account for arbitrary eavesdropping attacks by employing the concept of an equivalent protocol where the post-selection is implemented as a series of quantum operations including a virtual distillation. We introduce a particular `Gaussian' post selection and demonstrate that the security can be calculated using only experimentally accessible quantities. Finally we explicitly evaluate the performance for the case of a noisy Gaussian channel in the limit of unbounded key length and find improvements over all pre-existing continuous variable protocols in realistic regimes.
description: 4+4 pages. arXiv admin note: substantial text overlap with arXiv:1106.0825
Die Ausbreitung der Königssalbung im hochmittelalterlichen Europa
Creators: name: Schieffer, Rudolf
Publisher: name: Vorträge und Forschungen
Year: 2020

description: Vorträge und Forschungen, Bd. 84 (2017): Vorträge und Forschungen: Die mittelalterliche Thronfolge im europäischen Vergleich
Characterising Plasminogen and Receptor Interactions in Macrophage Function
Creators: name: MAZZITELLI, BLAKE ANTHONY
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 320407
subject: Innate immunity

description: Macrophages are crucial cells of the immune system, being vital players in the response against infection and injury. Macrophages rely on the protein Plasminogen and its receptors (known as Plasminogen Receptors) for a variety of important functions. In this thesis, we sought to understand the specific ways that Plasminogen mediates macrophage functions. We have investigated and gained new insights into the molecular interaction between Plasminogen and its receptors. Beyond these receptors, we have also begun to uncover new mechanisms by which Plasminogen regulates macrophage functions. This work will significantly enhance our understanding our macrophage functions in immunity and disease.
Thronfolgen im Mittelalter zwischen Erbe und Wahl, zwischen Legitimität und Usurpation, zwischen Kontingenz und (konstruierter) Kontinuität
Creators: name: Hartmann, Florian
Publisher: name: Vorträge und Forschungen
Year: 2020

description: Vorträge und Forschungen, Bd. 84 (2017): Vorträge und Forschungen: Die mittelalterliche Thronfolge im europäischen Vergleich
How do I diagnose Microscopic challenge: Kaposi Sarcoma of the oral mucosa
Creators: name: Kayser, Gian
name: Kayser, Claudia
Publisher: name: Diagnostic Pathology
Year: 2015
Subjects: Kaposi sarcoma;granulation tissue;human herpes virus 8;oral mucosa;immunohistochemistry; human immune deficiency virus

description: Kaposi Sarcoma is a rare vascular neoplasm of the skin and mucosal membranes associated with human herpes virus 8 (HHV-8) infection. It is usually associated with severe suppression of the immune system, e. g. in the setting of human immune deficiency virus (HIV) infection and aquired immune deficiency syndrome (AIDS). Here we present a case of a 33 year old female, who was diagnosed to be HIV-positive in march 2015. On physical examination petechial bleedings were recognized at the hard palate. The biopsy specimen showed an ulcerated squamous mucosa with granulation tissue. Single swollen endothelia within angulated vessels were suspicious for a vascular tumor. Immunohistochemical evaluation revealed proliferating endothelia positive for HHV-8. Thus, the diagnosis of a Kaposi Sarcoma within granulation tissue at the hard palate was made. The diagnosis of Kaposi Sarcoma can be very difficult, especially in the setting of concurrent inflammation. Immunohistochemical workup is therefore recommended and necessary to verify the diagnosis of Kaposi Sarcoma.
description: Diagnostic Pathology, 2015
Non linear travelling waves with diffusion
Creators: name: De Angelis, M.
name: Mazziotti, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 82D55-35K25-76N20

description: A third order parabolic operator L_εtypical of a non linear wave operator cal L_0 perturbed by viscous terms, is analyzed. Some particular solutions related to L_0 are explicitly determined and the initial value problem for L_εis considered. The parabolic-hyperbolic behaviour is analyzed and rigorous approximations of the solution are achieved.
Evaluation of the anthelminthic potential of traditional medicinal plant extracts
Creators: name: JAYAWARDENE, KALEHE LIYANAGE THARANGA DILRUKSHI
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310803
subject: Plant cell and molecular biology
classificationCode: 310902
subject: Animal cell and molecular biology

description: Worm infestation causes significant financial losses in agricultural animals around the world and cause substantial economic loss due to human infection in developing countries. The development of resistance to antiparasitic drugs is an emerging problem in the livestock sector and highlights the urgent need for new anthelmintics with novel modes of action. Natural compounds from plants provide a unique opportunity in the search for new, effective and safe antiparasitic drugs. This thesis explores the antiparasitic activity of medicinal plant extracts used by the ancient healers in Malaysia in order to fasten the drug discovery to cater to the urgent needs of new drugs.
How To Choose A License For Your Software
Creators: name: Sufi, Shoaib
Publisher: name: Zenodo
Year: 2015
Subjects: software, licensing, open source, advice

description: This talk was presented at the: Licensing, Sharing and funding council policy workshop - learn and ask - 14 September 2015 in Cambridge.

http://www.software.ac.uk/news/2015-08-14-licensing-sharing-and-funding-council-policy-workshop-learn-and-ask-14-september-201

The meeting was organised by Marta Teperek from the Research Operations Office, University of Cambridge.
Efficient Min-cost Flow Tracking with Bounded Memory and Computation
Creators: name: Lenz, Philip
Publisher: name: Karlsruhe
Year: 2015

description: This thesis is a contribution to solving multi-target tracking in an optimal fashion for real-time demanding computer vision applications. We introduce a challenging benchmark, recorded with our autonomous driving platform AnnieWAY. Three main challenges of tracking are addressed: Solving the data association (min-cost flow) problem faster than standard solvers, extending this approach to an online setting, and making it real-time capable by a tight approximation of the optimal solution.
title: "Statua femminile di offerente", arte romana, inv. CCC (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Ciccarello, Giulia
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Fluctuations, correlations and some other recent results from lattice QCD
Creators: name: Mukherjee, Swagato
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I summarize recent results from lattice QCD on a few selected topics which are of interest to the heavy-ion physics community. Special emphasis is placed upon observables related to fluctuations of conserved charges and their connection to event-by-event fluctuations in heavy-ion collision experiments.
description: Plenary talk at Quark Matter 2011, Annecy, France
Glucocorticoid regulation of lung and kidney organogenesis during mouse fetal development
Creators: name: SHORT, KELLY LOUISE
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310404
subject: Evolution of developmental systems

description: My thesis investigated how hormones help the growth of a developing baby in utero before birth. My studies showed that a steroid hormone called cortisol controls a complex network of genes and pathways to mature the newborn babies’ lung and kidney. Currently strong synthetic steroid drugs are used to treat very preterm babies and these can sometimes have adverse effects on their development. The new pathways I discovered will aid in the development of new therapeutic drugs to treat very preterm birth with reduced side effects.
Experimental Study on the Fundamental Combustion Characteristics of Biogas and Multiwalled Carbon Nanotubes blended Palm Oil Biodiesel
Creators: name: NURMUKAN, DASTAN
Publisher: name: Monash University
Year: 2021
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 90201 Automotive Combustion and Fuel Engineering (incl. Alternative/Renewable Fuels)
subject: FOS: Environmental engineering

description: The threat of traditional fossil fuel depletion and their impact on the environment caused an increased interest in the topic of renewable fuels. Our team, led by Dr. Manh-Vu Tran, dedicated our time and effort to understanding the combustion behavior of cleaner fuels. Our goal was to investigate how hydrogen blended biogas mixtures can become one of the highly effective alternative fuels. We also investigated the potential of unique material, known as carbon nanotubes, as the fuel additive to biodiesel. While much work is still needed in this research area, the future of clean fuels has very promising potential.
The role of PREX2 in breast cancer
Creators: name: JOEY MAN
Publisher: name: Monash University
Year: 2020
Subjects: subject: Cancer
subject: 60111 Signal Transduction
subject: FOS: Biological sciences
subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine

description: This thesis examines the role of the guanine nucleotide exchange factor PREX2 in breast cancer. Analysis of human breast cancer patient databases demonstrates that mammary tumours express high levels of PREX2 compared to normal breast tissues, and high PREX2 expression correlates with breast cancer metastasis. Using breast cancer cell line models, this thesis shows that PREX2 expression results in increased cell growth, survival, metastasis and malignant transformation. Expression of PREX2 or a PREX2 breast cancer mutant also alters actin polymerisation and breast cancer cell morphology. Therefore, PREX2 may serve as a potential therapeutic target in future breast cancer treatments.
Repeat investigation of 4.3 million variant positions using 52 highly diverse accessions of the model allopolyploid plant Brassica napus.
Creators: name: Schmutzer, Thomas
Publisher: name: e!DAL - Plant Genomics and Phenomics Research Data Repository (PGP), IPK Gatersleben, Seeland OT Gatersleben, Corrensstraße 3, 06466, Germany
Year: 2015
Subjects: Brassica napus
rapeseed
repeat investigation
k-mer analysis
diversity
variant position
PreBreed Yield

description: The B. napus Darmor-bzh genome assembly contains 34.5% transposable elements. We performed a repeat investigation for all 4.3 million determined variant
			positions (DOI:10.5447/IPK/2015/5). All variant positions (VPs) were compared to known repeat positions, given in the GFF annotation (v5) file of the B. napus Darmor-bzh reference (Chalhoub et al.
			2014, DOI: 10.1126/science.1253435). In addition a k-mer analysis was performed to provide further insights of the repeat constitution in our genotype collection (ENA project numbers PRJEB5974 and
			PRJEB6069). For each of the 52 resequenced accessions we used ~1-fold sequence data (down sampling) to construct individual k-mer (k=21) indices (totaling ~50-fold coverage). Each of these
			genotype-specific k-mer indices was used to analyze the 100bp flanking sequence (upstream and downstream) of a VP. The results are provided in this DOI resource, which includes 41 tables and
			provides useful repeat characteristic for a VP. These tables refer to the 19 chromosomes and 22 ‘random’ chromosomes. The latter ones include ‘random’ scaffolds that failed to be incorporated into
			the chromosomes, but are assigned to a specific chromosome. Furthermore, two additional ‘random’ scaffolds are included that contain sequences that were assigned to a subgenome (A or C subgenome),
			but not to specific chromosome. Finally, the last ‘random’ sequences refer to those sequences that remain unassigned to any subgenome. The first three columns contain the most relevant information
			with 1) chromosome position, 2) repeat classification based on the GFF annotation, and 3) repeat classification based on the k-mer statistics. The binary classification is true (1 = repeat), if the
			particular VP overlaps a repeat in the GFF file, otherwise (0). The classification in the third column is true (1 = repeat), if the average k-mer frequency threshold (20) is exceeded. Here, the 8th
			and the 13th column of the tables are used. These contain the 3rd quartile (Q3) of all 52 individual k-mer genotype-specific k-mer values of the left (8th column) and the right (13th column)
			flanking sequence of a VP. If at least one exceeds the threshold the flanking sequence of the VP is characterized as repeat. The information provided in the tables enables a more profound selection
			of VPs that are less likely to be affected by repeats.
Resumption-based big-step and small-step interpreters for While with interactive I/O
Creators: name: Nakata, Keiko
Publisher: name: arXiv
Year: 2011
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: In this tutorial, we program big-step and small-step total interpreters for the While language extended with input and output primitives. While is a simple imperative language consisting of skip, assignment, sequence, conditional and loop. We first develop trace-based interpreters for While. Traces are potentially infinite nonempty sequences of states. The interpreters assign traces to While programs: for us, traces are denotations of While programs. The trace is finite if the program is terminating and infinite if the program is non-terminating. However, we cannot decide (i.e., write a program to determine), for any given program, whether its trace is finite or infinite, which amounts to deciding the halting problem. We then extend While with interactive input/output primitives. Accordingly, we extend the interpreters by generalizing traces to resumptions. The tutorial is based on our previous work with T. Uustalu on reasoning about interactive programs in the setting of constructive type theory.
description: In Proceedings DSL 2011, arXiv:1109.0323
Glockenstuhlsanierung im Nordturm
Creators: name: Hau, Martin
Publisher: name: Unser Münster / Die Informationsschrift des Münsterbauvereins Breisach e.V.
Year: 2019

description: Unser Münster / Die Informationsschrift des Münsterbauvereins Breisach e.V., Nr. 56 (2019): Unser Münster: 1650 Jahre Stadt Breisach
Star-free geodesic languages for groups
Creators: name: Hermiller, S.
name: Holt, Derek F.
name: Rees, Sarah
Publisher: name: arXiv
Year: 2011
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F06, 20F10, 20F67, 68Q45

description: In this article we show that every group with a finite presentation satisfying one or both of the small cancellation conditions $C'(1/6)$ and $C'(1/4)-T(4)$ has the property that the set of all geodesics (over the same generating set) is a star-free regular language. Star-free regularity of the geodesic set is shown to be dependent on the generating set chosen, even for free groups. We also show that the class of groups whose geodesic sets are star-free with respect to some generating set is closed under taking graph (and hence free and direct) products, and includes all virtually abelian groups.
MFSD2A in focus: the molecular mechanism of omega-3 fatty acid transportSupplementary Information
Creators: name: Blades, Farrah
name: Torun Yazici, Aysenur
name: Cater, Rosemary
name: Mancia, Filippo
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: MFSD2A in focus: the molecular mechanism of omega-3 fatty acid transport
Superatom molecular orbitals: a new type of long-lived electronic states
Creators: name: Pavlyukh, Y.
name: Berakdar, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present ab initio calculations of the quasiparticle decay times in a Buckminsterfullerene based on the many-body perturbation theory. A particularly lucid representation arises when the broadening of the quasiparticle states is plotted in the angular momentum and energy coordinates. In this representation the main spectroscopic features of the fullerene consist of two occupied nearly parabolic bands, and delocalized plane-wave-like unoccupied states with a few long-lived electronic states (the superatom molecular orbitals, SAMOs) embedded in the continuum of Fermi-liquid states. SAMOs have been recently uncovered experimentally by M. Feng, J. Zhao, and H. Petek [Science 320, 359 (2008)] using scanning tunneling spectroscopy. The present calculations offer an explanation of their unusual stability and unveil their long-lived nature making them good candidates for applications in the molecular electronics. From the fundamental point of view these states illustrate a concept of the Fock-space localization [B. L. Altshuler, Y. Gefen, A. Kamenev, and L. S. Levitov, Phys. Rev. Lett. 78, 2803 (1997)] with properties drastically different from the Fermi-liquid excitations.
The Characterisation of Novel Pathways for the Induction of Mammalian Mitophagy
Creators: name: LAM, WAI KIT
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310803
subject: Plant cell and molecular biology
classificationCode: 310902
subject: Animal cell and molecular biology

description: Most cells in the human body are in a non-dividing state called quiescence. If quiescence does not function correctly, diseases such as fibrosis or cancer can develop. Inside cells, organelles called mitochondria supply energy. To remain healthy, mitochondria must go through disposal (called mitophagy) and renewal. This thesis discovers in quiescent cells, more mitochondria go through disposal than in dividing cells. It shows that mitophagy triggers renewal of mitochondria and helps quiescent cells to stay healthy. A new mechanism of mitophagy was identified. The findings ultimately could be used to develop drugs that prevent these quiescent cells from causing disease.
Coupling between quantum Hall state and electromechanics in suspended graphene resonator
Creators: name: Singh, Vibhor
name: Irfan, Bushra
name: Subramanian, Ganesh
name: Solanki, Hari S.
name: Sengupta, Shamashis
name: Dubey, Sudipta
name: Kumar, Anil
name: Ramakrishnan, S.
name: Deshmukh, Mandar M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using graphene resonator, we perform electromechanical measurements in quantum Hall regime to probe the coupling between a quantum Hall (QH) system and its mechanical motion. Mechanically perturbing the QH state through resonance modifies the DC resistance of the system and results in a Fano-lineshape due to electronic interference. Magnetization of the system modifies the resonator's equilibrium position and effective stiffness leading to changes in resonant frequency. Our experiments show that there is an intimate coupling between the quantum Hall state and mechanics - electron transport is affected by physical motion and in turn the magnetization modifies the electromechanical response.
description: For supplemental material please go to http://www.tifr.res.in/~nano/publications.htm
Impact of Fusarium spp. infection of bread wheat (Triticum aestivum L.) on composition and quality of flour in association with EU maximum level for deoxynivalenol
Creators: name: Kreuzberger, Marie
name: Limsuwan, Sasithorn
name: Eggert, Kai
name: Karlovsky, Petr
name: Pawelzik, Elke
Publisher: name: Journal of Applied Botany and Food Quality
Year: 2015
Subjects: Wheat, Fusarium graminearum, deoxynivalenol, mycotoxins, processing, milling

description: Contamination of grain with mycotoxins such as deoxynivalenol (DON) is the major threat after Fusarium head blight (FHB) infection of wheat, however technological quality can also be impaired. The European Union has established maximum levels (ML) of DON for wheat grain and foodstuffs. The composition (starch, gluten proteins) and quality (protein content, sedimentation value, wet gluten, water absorption, mixing properties of dough, baking volume) of 72 flour Type 550 samples from two years either fulfilling or exceeding ML of 0.75 mg kg-1 were investigated. DO content of flours ranged widely from below limit of quantification to 11.84 mg kg-1. Aside from a slight loss of loaf shape in flours highly exceeding ML, no negative effect on composition and quality of flour was observed in flours exceeding ML compared to those fulfilling ML. A significant decrease in total glutenin and LMW-GS content did not correlate with any quality trait. Hence, if flours fulfill ML for DON, reduced technological quality due to FHB is not significant.
description: Journal of Applied Botany and Food Quality, Vol 88 (2015), p.177-185
Curriculum development in university mathematics: where mathematicians and education collide
Creators: name: Sangwin, Christopher J.
Publisher: name: Mathematisches Forschungsinstitut Oberwolfach
Year: 2015
Subjects: Analysis
Reflections on mathematics

description: This snapshot looks at educational aspects of the design of curricula in mathematics. In particular, we examine choices textbook authors have made when introducing the concept of the completness of the real numbers. Can significant choices really be made? Do these choices have an effect on how people learn, and, if so, can we understand what they are?
description: Snapshots of modern mathematics from Oberwolfach; No. 11/2015
Biochemical characterisation of non-ribosomal peptide synthetases from glycopeptide antibiotic biosynthesis
Creators: name: MILDA KANIUSAITE
Publisher: name: Monash University
Year: 2020
Subjects: Biochemistry
Molecular Biology

description: In this study, the entire glycopeptide antibiotic teicoplanin biosynthesis non-ribosomal peptide synthetase (NRPS) assembly line was analysed. Our findings provided deeper mechanistic understanding how peptide biosynthesis assembly lines function. Here, for the first time using A-domain amino acid activation assays and assembly line reassembly, we have reconstituted the activity of all NRPS modules from the biosynthesis of the antibiotic teicoplanin and demonstrated the formation of the teicoplanin heptapeptide precursor biosynthesis in vitro. In addition, several novel biosynthetic pathway reengineering strategies, were designed and experimentally demonstrated, which allow the biosynthesis of peptides with altered sequences.
The role of PPARγ mediated regulation of peroxisomal phospholipid metabolism in tumour lipidomic reprogramming and chemoresistance
Creators: name: SPENCER THOMAS KEITH FOXWELL GREATOREX
Publisher: name: Monash University
Year: 2020
Subjects: subject: 60104 Cell Metabolism
subject: FOS: Biological sciences
subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine

description: This thesis focused on unraveling metabolic reprogramming in human tumours. In particular, the study presented focuses on PPARγ signalling network in BRAFV600E driven colorectal cancers through regulation of peroxisomal phospholipid biosynthesis pathways. PPARγ mediated regulation of peroxisomal lipid metabolism was shown as a key regulator of intracellular lipid storage and further drove chemoresistance and cancer stem like phenotypes. Altered tumour metabolism is an important mechanism of drug resistant tumours and targeting tumour metabolism provides and exciting therapeutic opportunity.
Regulation of Innate Antiviral Immunity by Host and Bacterial E3 Ligases
Creators: name: MELISSA NOEL SWEENEY
Publisher: name: Monash University
Year: 2020
Subjects: Biochemistry

description: This thesis explores the interactions of host and bacterial proteins in the innate immune system during infection. The work presented shows that host proteins within the RIG-I-like receptor (retinoic acid-inducible gene-I-like receptors, RLRs) signalling cascade are subject to post-translational modification, and also binding by bacterial proteins, presumably as a means of regulating antiviral immunity to benefit the host or the pathogen, respectively. Uncovering the mechanisms by which host and bacterial proteins interact will help to identify novel therapeutic targets for combating infections.
Dendritic cell targeted vaccines against cancer
Creators: name: FILIPP ESSELBORN
Publisher: name: Monash University
Year: 2020
Subjects: subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine

description: Cancer immunotherapy uses the power of an army of defender cells, such as dendritic cells and T cells, to eradicate cancer. This study used a mouse model to develop an innovative vaccine that educated dendritic cells about the presence of cancer and allowed them to instruct T cells, the soldiers, to start attacking lung metastasis of melanoma. This research explored different types of melanoma-derived molecules and their suitability as vaccine targets. The results of this thesis may guide the development of more potent cancer therapies in humans.
Qubit flip game on a Heisenberg spin chain
Creators: name: Miszczak, Jarosław A.
name: Gawron, Piotr
name: Puchała, Zbigniew
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study a quantum version of a penny flip game played using control parameters of the Hamiltonian in the Heisenberg model. Moreover, we extend this game by introducing auxiliary spins which can be used to alter the behaviour of the system. We show that a player aware of the complex structure of the system used to implement the game can use this knowledge to gain higher mean payoff.
description: 13 pages, 3 figures, 3 tables
Vivo Use Case Dresden #Vivode15 9.9.2015
Creators: name: Lohmeier, Felix
name: Wolff, Stefan
Publisher: name: Zenodo
Year: 2015
Subjects: cris
dresden
fis
forschungsinformationen
linked open data
open source
vivo

description: “VIVO als Forschungsinformationssystem in der Praxis”

Workshop, 9.9.2015, Hannover

http://blogs.tib.eu/wp/vivo/
Characterisation of the roles of the YEATS domain proteins in the human fungal pathogen Candida albicans
Creators: name: QI WANG
Publisher: name: Monash University
Year: 2020
Subjects: Molecular Biology

description: An important facet of C. albcians virulence is the ability to reprogram its biology by changing gene expression to meet challenges. Post-transcriptional modifications (PTMs) of histone proteins might connect metabolic and stress inputs to biological outputs. My thesis revealed broad roles of the histone crotonylation YEATS readers Taf14 and Yaf9 in fitness, stress responses, invasive growth and virulence of C. albicans. These roles are driven by the reader function of the N-terminal YEATS domain and the C-terminus to different degrees. My thesis provides the knowledge foundation for the ability to target fungal YEATS proteins in future antifungal drug discovery efforts.
Accurate Programming: Thinking about programs in terms of properties
Creators: name: Taha, Walid
name: Gaspes, Veronica
name: Page, Rex
Publisher: name: arXiv
Year: 2011
Subjects: subject: Programming Languages (cs.PL)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Accurate programming is a practical approach to producing high quality programs. It combines ideas from test-automation, test-driven development, agile programming, and other state of the art software development methods. In addition to building on approaches that have proven effective in practice, it emphasizes concepts that help programmers sharpen their understanding of both the problems they are solving and the solutions they come up with. This is achieved by encouraging programmers to think about programs in terms of properties.
description: In Proceedings DSL 2011, arXiv:1109.0323
Calibration of electronic measurement boards and length values recorded in the Fisheries Scientific Computing System (FSCS).
Creators: name: Price, Victoria
name: Godlewski, Joseph Michael
name: Jech, Josef Michael
name: McHugh, Nancy J.
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Northeast Fisheries Science Center.
Year: 2015
Subjects: subject: Fishes--Growth--Measurement--Instruments.

description: Measured length distributions of Atlantic herring (Clupea harengus) were not identical between midwater trawl catches from the fall systematic herring survey and bottom trawl catches from the fall stratified-random survey conducted by the Northeast Fisheries Science Center (NEFSC) from 1998 to 2012. The Scantrol FishMeter fish measurement board was used during the stratified-random bottom trawl survey, while the Ichthystick II Electronic Fish Measuring Board was used during the systematic herring survey. Both sets of measurements were recorded by the Fisheries Scientific Computing System (FSCS). We investigated whether differences in length-measurement systems caused discrepancies in length distributions between the 2 surveys. Our initial concern was that the Scantrol board may have rounded up to the nearest 0.5 centimeter on measurement and that on recording into FSCS the measurement was again rounded up to the nearest whole centimeter. In the first set of measurements, dowels were cut to known lengths, randomized, measured with each board, and recorded into FSCS. Three different measurement boards of each type were compared to assess variability within each board type. The actual board measurements and the recorded FSCS values were compared against the known values. Systematic biases were observed in 2 of the Scantrol boards, prompting a series of systematic measurements on all Scantrol boards. All fish lengths stored in FSCS from Scantrol boards were positively biased by 0.25 cm, and some boards appear to have a mechanical offset that can increase the bias up to 0.50 cm when compared to true lengths. We cannot completely rule out instrument error as the cause of discrepancies in mean Atlantic herring lengths between surveys, but the effects of rounding by the Scantrol boards and FSCS do not appear to explain the magnitude of the differences. Biological and sampling factors should be investigated as the cause of length distribution discrepancies between surveys.
Understanding the molecular basis of how sequence polymorphism of the H. pylori virulence factor CagL influences gastric cancer risks in H. pylori-infected patients.
Creators: name: HANAN EID G ALYAHIWI
Publisher: name: Monash University
Year: 2020
Subjects: Biochemistry
Molecular Biology

description: H. pylori is a common type of bacteria found in the stomach. It can cause inflammation, ulcers and changes to cells in the lining of the stomach. While H. pylori can increase the risk, not all people infected with H. pylori will develop stomach cancer. This thesis examines how genetic variation of an important bacterial protein, H. pylori CagL, could influence the risk of developing gastric cancer. It identifies possible protein types that can measurably modulate host responses during H. pylori infection. It establishes that CagL could be used as a biomarker to identify H. pylori infected individuals prone to gastric cancer.
A coincidental timing model for the scintillating fibers
Creators: name: Žugec, Petar
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: A model describing the coincidental timing of scintillating fibers is developed. Fiber geometry, the rate of scintillation decay together with the mean number, spatial dispersion and attenuation of emitted photons is considered. For a specific selection of probability distributions and parameters involved, the entire coincidental timing distributions, corresponding FWHM values and the photon detection efficiencies are extracted. The significance of the number of photons from the scintillation process is specially emphasized. Additionally, the model is extended to include a triggering feature, experimentally realized by coupling fibers to any photon resolving device. Finally, the measurements of a coincidental timing distribution were performed, with an excellent agreement found between the experimental and predicted theoretical results.
Progress towards quantum-enhanced interferometry with harmonically trapped quantum matter-wave bright solitons: Supporting data
Creators: name: Gertjerenken, Bettina
name: Wiles, Timothy P.
name: Weiss, Christoph
Publisher: name: Durham University
Year: 2015
Subjects: Bose-Einstein condensation
bright soliton

description: Supporting data for the publication "Progress towards quantum-enhanced interferometry with harmonically trapped quantum matter-wave bright solitons"
description: Replaced with http://dx.doi.org/doi:10.15128/r2ft848q60b
A data-driven bioinformatic investigation into protein post-translational modifications
Creators: name: FUYI LI
Publisher: name: Monash University
Year: 2020
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences
subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Computational Biology
subject: 60102 Bioinformatics
subject: Computer Software

description: To address the post-translational modification (PTM) site identification problem, this thesis focuses on developing data-driven bioinformatic approaches to predict PTM substrates and sites from sequence and/or structural information. Specifically, this thesis presents four novel machine learning frameworks and a comprehensive 3D structure database of PTMs. Each of the four frameworks represents a solution to one type of PTM prediction problem. Extensive benchmarking experiments demonstrate that these four frameworks show a competitive and robust performance in their particular PTM site prediction problems. In addition, publicly available online webservers have been developed and deployed as implementations of these frameworks to facilitate bioinformatics studies of novel PTM sites and generate novel biological hypotheses.
A nonlinear scalar model of extreme mass ratio inspirals in effective field theory II. Scalar perturbations and a master source
Creators: name: Galley, Chad R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The motion of a small compact object (SCO) in a background spacetime is investigated further in a class of model nonlinear scalar field theories having a perturbative structure analogous to the General Relativistic description of extreme mass ratio inspirals (EMRIs). We derive regular expressions for the scalar perturbations generated by the SCO's motion valid through third order in $ε$, the size of the SCO to the background curvature length scale. Our expressions are compared to those calculated through second order in $ε$ by Rosenthal in [E. Rosenthal, CQG 22, S859 (2005)] and found to agree but our procedure for regularizing the scalar perturbations is considerably simpler. Following the Detweiler-Whiting (DW) scheme, we use our regular expressions for the field and derive the regular self-force corrections through third order. We find agreement with our previous derivation based on a variational principle of an effective action for the worldline associated with the SCO thus demonstrating the internal consistency of our formalism. This also explicitly demonstrates that the DW decomposition of Green's functions is a valid and practical method of self force computation at higher orders in perturbation theory and, as we show in an appendix, at all orders in perturbation theory. Finally, we identify a master source from which all other physically relevant quantities are derivable. Knowing the master source perturbatively allows one to construct the waveform measured by an observer, the regular part of the field on the worldline, the regular part of the self force, and orbital quantities such as shifts of the innermost stable circular orbit, etc. The existence of a master source together with the regularization methods implemented in this series should be indispensable for derivations of higher-order gravitational self force corrections.
description: For Part 1 of this series, see arXiv:1012.4488. 20 pages, 7 figures