cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From left-skewness to symmetry: how body-height distribution among Swiss conscripts has changed shape since the late 19th century
Creators: name: Staub, Kaspar
name: Woitek, Ulrich
name: Rühli, Frank
name: Floris, Joël
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Molecular Biology
Cell Biology

description: Background: It is generally accepted that height distribution in modern populations is nearly symmetrical. However, it may deviate from symmetry when nutritional status is inadequate.Aim and subjects: This study provides an analysis of changes in the shape of the height distributions among Swiss conscripts (n = 267 829) over the past 130 years based on a highly representative, standardized and unchanged data source.Results: The analysed distributions from the 1870s–1890s conscription years are markedly left-skewed (−0.76 to −0.82), with short and very short men significantly over-represented. Standard deviation is 7.7 cm. In particular, the left tails of the late-19th- and early-20th-century distributions are very heavy. In the first half of the 20th century the first signs of a diminution of the heavy left tail are observable, by the 1970s the phenomenon disappears and height distribution becomes symmetrical; standard deviation is now 6.5 cm.Conclusion: The relatively strong left-skewness during the late 19th and early 20th centuries may have been due to the interaction of a number of causes, chiefly malnutrition, a wider range in physical development at age 19 and widespread iodine deficiency.
Dried Distillers Grains (DDGs) Have Emerged as a Key Ethanol Coproduct
Creators: name: Olson, David W.
name: Capehart, Thomas
name: Olson, David W.
name: Capehart, Thomas
Publisher: name: Unknown
Year: 2019
Subjects: subject: Crop Production/Industries
subject: Production Economics
subject: Research and Development/Tech Change/Emerging Technologies
subject: Resource /Energy Economics and Policy
subject: bioenergy
subject: ethanol coproduct
subject: dried distillers grains (DDGs)
subject: feed grains
subject: corn

description: ERS researchers analyzed USDA bioenergy data to understand the size of ethanol coproduct markets. Dried distillers’ grains, or DDGs, were the most significant coproduct from ethanol production, in both size and value.
Combating the Scourge of Child Marriage 24-Apr-2022 09-41-35.pdf
Creators: name: Ekpo, Mokutima  Etido
Publisher: name: figshare
Year: 2022
Subjects: subject: 220305 Ethical Theory
subject: FOS: Philosophy, ethics and religion
subject: 180113 Family Law
subject: FOS: Law
subject: 220306 Feminist Theory
subject: Gender studies
subject: 130308 Gender, Sexuality and Education
subject: FOS: Educational sciences

description: Child marriage and its attendant serious and multiple consequences amplify contemporary trends occurring predominantly in Nigeria and the girlschild is the central victim...
Removal of Copper and Zinc from Ground Water by Granular Zero-Valent Iron: A Mechanistic Study
Creators: name: Statham, Tom M.
name: Mumford, Kathryn A.
name: Stark, Scott C.
name: Gore, Damian B.
name: Stevens, Geoffrey W.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Medicine

description: Designing water treatment systems with contaminant removal based on zero-valent iron (ZVI) requires an understanding of the formation of a series of iron oxyhydroxides produced during corrosion of the thermodynamically unstable ZVI core. X-ray diffractometry (XRD) and geochemical modelling were used to investigate the mechanisms of copper and zinc removal and the formation of iron oxyhydroxides in batch experiments at 4 and 25°C, over a period of 349 days. Copper removal was predominantly associated with a mineral product, which was unstable in an aerobic environment. Zinc and some copper were sequestered into the iron oxyhydroxide structure and did not redissolve when the pH was reduced. X-ray diffractometry and geochemical modelling suggest that ZVI reacted to form magnetite and lepidocrocite, with lepidocrocite being the most stable mineral observed under the experimental conditions. However, XRD analysis did not allow the identification of poorly crystalline intermediate or substituted products which were most likely also present.Capsule During zero-valent iron treatment heavy metal contaminants are sequestered into iron oxyhydroxide structures formed during corrosion.
User-Extensible Compiler Toolchains for Refactoring CSE Software
Creators: name: Kartsaklis, Christos
name: Davd E. Bernholdt
name: Wang, Dali
Publisher: name: figshare
Year: 2015
Subjects: subject: Computer Software
subject: FOS: Computer and information sciences

description: Position paper accepted for presentation at the Computational Science & Engineering Software Sustainability and Productivity Challenges (CSESSP
Challenges) Workshop, which is sponsored by the Networking and Information Technology Research and Development (NITRD) Software Design and Productivity (SDP) Coordinating Group, held on the 15th and 16th of October 2015 in Washington DC, USA. It discusses how compiler directive API technologies can serve as means for extending the compiler toolchain for user-specific CSE software analysis, refactoring and optimization tasks.
Prospective study of cost of care at multidisciplinary ALS centers adhering to American Academy of Neurology (AAN) ALS practice parameters
Creators: name: Boylan, Kevin
name: Levine, Todd
name: Lomen-Hoerth, Catherine
name: Lyon, Mary
name: Maginnis, Kimberly
name: Callas, Peter
name: Gaspari, Celeste
name: Rup Tandan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Multidisciplinary care in ALS is associated with longer survival, improved quality of life, and reduced hospital admissions, but there are no published data on institutional costs associated with multidisciplinary ALS care at U.S. centers. We prospectively examined institutional costs, adherence to AAN Practice Parameters and patient satisfaction in multidisciplinary ALS clinics at 18 U.S. ALS centers. Centers reported patient volumes; direct costs for staff salary/benefits, supplies and equipment; and institutional non-salary and overhead costs over a three-month period. In 1117 patients seen during this period, mean age was 61.5 years (range 25–91 years), 56% were male, and mean ALSFRS-R score was 29. Mean total salary/benefit cost per clinic day for all providers was $2964 (range $1692–$5236 across centers). Mean salary/benefit cost per patient per clinic was $507 (range $258–$806 across centers). Differences among centers in reporting non-salary costs prevented meaningful analysis. Practice parameter adherence and patient satisfaction were high. This prospective collaborative study demonstrates the direct financial burden of evidence-based multidisciplinary ALS care in the U.S.; more refined non-salary and overhead cost data are needed to evaluate the full cost impact of care. These data may be useful in supporting evidence-based models of patient centered care for ALS.
Prospective study of cost of care at multidisciplinary ALS centers adhering to American Academy of Neurology (AAN) ALS practice parameters
Creators: name: Boylan, Kevin
name: Levine, Todd
name: Lomen-Hoerth, Catherine
name: Lyon, Mary
name: Maginnis, Kimberly
name: Callas, Peter
name: Gaspari, Celeste
name: Rup Tandan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Multidisciplinary care in ALS is associated with longer survival, improved quality of life, and reduced hospital admissions, but there are no published data on institutional costs associated with multidisciplinary ALS care at U.S. centers. We prospectively examined institutional costs, adherence to AAN Practice Parameters and patient satisfaction in multidisciplinary ALS clinics at 18 U.S. ALS centers. Centers reported patient volumes; direct costs for staff salary/benefits, supplies and equipment; and institutional non-salary and overhead costs over a three-month period. In 1117 patients seen during this period, mean age was 61.5 years (range 25–91 years), 56% were male, and mean ALSFRS-R score was 29. Mean total salary/benefit cost per clinic day for all providers was $2964 (range $1692–$5236 across centers). Mean salary/benefit cost per patient per clinic was $507 (range $258–$806 across centers). Differences among centers in reporting non-salary costs prevented meaningful analysis. Practice parameter adherence and patient satisfaction were high. This prospective collaborative study demonstrates the direct financial burden of evidence-based multidisciplinary ALS care in the U.S.; more refined non-salary and overhead cost data are needed to evaluate the full cost impact of care. These data may be useful in supporting evidence-based models of patient centered care for ALS.
Studies on Ni(II), Cu(II) and Zn(II) complexes with 2-aminobenzamide and some bioactive imidazole enzyme constituents
Creators: name: Jeyaprakash Dharmaraja
name: Subbaraj, Paramasivam
name: Thirugnanasamy Esakkidurai
name: Sutha Shobana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: A series of Ni(II), Cu(II), and Zn(II) complexes of 2-aminobenzamide(2AB : L) and some imidazole enzyme constituents(B) viz., imidazole(him), benzimidazole(bim), histamine(hist), and L-histidine(his) have been synthesized and characterized using analytical and various spectral studies. Vibrational spectral data of the synthesized complexes reveal that the ligands bind with metal(II) ions through nitrogen and oxygen. The calculated g-tensor values of Cu(II) complexes suggest that the unpaired electron is localized in the orbital. The results obtained from the spectral studies confirm the distorted octahedral environment around the metal(II) ions. Their powder XRD indicates microcrystalline nature and SEM pictographs identify their uniform surface morphology. Cu(II) and Ni(II) complexes show biological, antioxidant, and DNA activities when compared to free 2-aminobenzamide. Equilibrium studies have been carried out pH-metrically in 50% (v/v) water–ethanol mixture at 37 °C and I = 0.15 mol dm−3 NaClO4. Analysis reveals the presence of certain heteroligand species viz., MLBH/MLB/MLB2, in addition to various primary species. In MLB/MLB2 species, 2AB(L) binds with M(II) ions via N-amino and O-amido, whereas the ligands(B) him and bim are monodentate, hist and his are bi and tridentate, respectively. The stabilization parameters Δ log K, log X, log X′, and % RS clearly indicate all the heteroligand complexes have higher stabilities than their primary.
Suppression of the skyrmion Hall effect in synthetic ferrimagnets with gradient magnetization
Creators: name: Bo, Lan
name: Zhang, Xichao
name: Mochizuki, Masahito
name: Zhang, Xuefeng
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Magnetic skyrmions are promising building blocks for future spintronic devices. However, the skyrmion Hall effect (SkHE) remains an obstacle for practical applications based on the in-line transport of skyrmions. Here, we numerically study the static properties and current-driven dynamics of synthetic ferrimagnetic skyrmions. Inspired by graded-index magnonics, we introduce a linear gradient of saturation magnetization (Ms) in the skyrmion-hosting sample, which effectively modulates the skyrmion Hall angle and suppresses the SkHE. Micromagnetic simulations reveal that ferrimagnetic skyrmions could exhibit greater susceptibility to the variation of Ms as compared to their ferromagnetic counterparts. The Thiele analysis is also applied to support the simulation results, which elucidates that the Ms gradient dynamically modifies the intrinsic normalized size of skyrmions, consequently impacting the SkHE. Our results pave the way to the graded-index skyrmionics, which offers novel insights for designing ferrimagnet-based skyrmionic devices.
description: 9 pages, 5 figures
title: ІННОВАЦІЙНІ ТЕХНОЛОГІЇ НАВЧАННЯ ІНТЕГРОВАНОГО КУРСУ "Я ДОСЛІДЖУЮ СВІТ"
title: Методичні рекомендації до проведення практичних, лабораторних занять  та самостійної роботи з навчальної дисципліни
titleType: AlternativeTitle
Creators: name: Хом'як, Ольга
Publisher: name: Zenodo
Year: 2023
Subjects: Початкова освіта
Інноваційні технології
Інтегрований курс

description: Методичні рекомендації до проведення практичних, лабораторних занять та самостійної роботи з навчальної дисципліни «Інноваційні технології навчання інтегрованого курсу «Я досліджую світ»» для здобувачів другого рівня вищої освіти (магістерського), галузі знань 01 Освіта/Педагогіка, спеціальності 013 «Початкова освіта» / уклад. О. А Хом'як. Рівне : видавець О. Зень, 2023. 156 с. 
description: Методичні рекомендації містять комплекс матеріалів, структурованих відповідно до навчальної програми дисципліни «Інноваційні технології навчання інтегрованого курсу «Я досліджую світ»». Змістове наповнення охоплює аудиторну, самостійну та індивідуально-дослідну роботу студентів, надаючи їй системності, послідовності, сприяє формуванню цілісного погляду на проблеми навчальної дисципліни та розвитку достатнього рівня узагальнення матеріалів.Рекомендується для студентів педагогічних факультетів.
A new kaurane diterpenoid from Isodon inflexus
Creators: name: Xu, Guang-Hua
name: Cai, Xing-Fu
name: Xuejun Jin
name: Lee, Jung Joon
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Hematology

description: A new 7,20-epoxy kaurane diterpenoid, 15-acetyldemethylkamebacetal A (1) and six known kaurane diterpenoids (2–7) were isolated from the aerial parts of Isodon inflexus in nuclear transcription factor-κB (NF-κB)-dependent reporter gene assay-guided fractionation. Their chemical structures were determined on the basis of extensive spectroscopic analysis (UV, IR, MS, 1D- and 2D-NMR) and comparison with literature data. The isolated compounds were evaluated for their inhibitory effects on TNF-α-induced NF-κB activation, and all compounds exhibited NF-κB inhibitory activities with IC50 values ranging from 1.91 to 20.15 μM.
A new kaurane diterpenoid from Isodon inflexus
Creators: name: Xu, Guang-Hua
name: Cai, Xing-Fu
name: Xuejun Jin
name: Lee, Jung Joon
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Hematology

description: A new 7,20-epoxy kaurane diterpenoid, 15-acetyldemethylkamebacetal A (1) and six known kaurane diterpenoids (2–7) were isolated from the aerial parts of Isodon inflexus in nuclear transcription factor-κB (NF-κB)-dependent reporter gene assay-guided fractionation. Their chemical structures were determined on the basis of extensive spectroscopic analysis (UV, IR, MS, 1D- and 2D-NMR) and comparison with literature data. The isolated compounds were evaluated for their inhibitory effects on TNF-α-induced NF-κB activation, and all compounds exhibited NF-κB inhibitory activities with IC50 values ranging from 1.91 to 20.15 μM.
Molecular modelling studies on 2-substituted octahydropyrazinopyridoindoles for histamine H2 receptor antagonism
Creators: name: M. Saxena
name: S.S. Bhunia
name: A.K. Saxena
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Neuroscience
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The human histamine H2 receptor (hH2HR) is a G-protein coupled receptor protein with seven transmembrane (TM)-spanning helices primarily involved in regulation of gastric acid secretion. Antagonists targeting hH2HR are useful in the treatment of hyperacidic conditions such as peptic ulcers, gastresophageal reflux disease and gastrointestinal bleeding. We have previously reported the antagonism of 2-substituted pyrazinopyridoindoles at the human histamine H1 receptor and mode of binding of these compounds at the hH1HR using in silico methods. Interestingly, some of the compounds in the series also showed promising activity towards hH2HR that prompted us to investigate the mode of binding of these compounds at hH2HR. In the absence of the crystal structure of hH2HR a homology model has been constructed using multiple sequence alignment, using the X-ray crystal structures of Turkey β1-adrenergic receptor (tβ1AR), Human histamine H1 receptor (hH1HR), Human β2-adrenergic receptor (hβ2AR) and Human D3 dopamine receptor (hD3R). The important residues for binding were depicted in TMIII, TMV, TMVI and TMVII by the homology modelled hH2HR for 2-substituted pyrazinopyridoindoles. A comparative study for deducing the selectivity regarding the binding towards hH1HR and hH2HR has been carried out, which may be useful in designing of selective hH1HR/hH2HR antagonists in these classes of compounds.
Studies on Ni(II), Cu(II) and Zn(II) complexes with 2-aminobenzamide and some bioactive imidazole enzyme constituents
Creators: name: Jeyaprakash Dharmaraja
name: Subbaraj, Paramasivam
name: Thirugnanasamy Esakkidurai
name: Sutha Shobana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: A series of Ni(II), Cu(II) and Zn(II) complexes of 2–aminobenzamide(2AB:L) and some imidazole enzyme constituents(B) viz., imidazole(him), benzimidazole(bim), histamine(hist) and L–histidine(his) have been synthesized and characterized using analytical and various spectral studies. Vibrational spectral data of the synthesized complexes reveal that the ligands bind with metal(II) ions through nitrogen and oxygen. The calculated g–tensor values of Cu(II) complexes suggest that the unpaired electron is localized in the dx2-y2 orbital. The results obtained from the spectral studies confirm the distorted octahedral environment around the metal(II) ions. Their powder XRD indicates microcrystalline nature and SEM pictographs identify their uniform surface morphology. Cu(II) and Ni(II) complexes show biological, antioxidant and DNA activities when compared to free 2–aminobenzamide. Equilibrium studies have been carried out pH–metrically in 50% (v/v) water–ethanol mixture at 37 °C and I = 0.15 mol dm−3 NaClO4. Analysis reveals the presence of certain hetero ligand species viz., MLBH/MLB/MLB2, in addition to various primary species. In MLB/MLB2 species, 2AB(L) binds with M(II) ions via N-amino and O-amido whereas the ligands(B) him and bim are monodentate, hist and his are bi and tridentate, respectively. The stabilization parameter Δ log K, log X, log X’ and % R.S. clearly indicate all the hetero ligand complexes have higher stabilities than their primary.
Trastuzumab-induced cardiotoxicity in elderly women with HER-2-positive breast cancer: a meta-analysis of real-world data
Creators: name: Leung, Henry WC
name: Chan, Agnes LF
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biotechnology

description: Background: We conducted a meta-analysis to assess the overall risk of cardiac toxicity associated with trastuzumab treatment in elderly breast cancer patients. Methods: We searched databases from PubMed, EMBASE and Cochrane Central Registry of Controlled Trials to identify relevant studies. Statistical analyses were conducted to calculate the incidence rate, overall hazard ratio (HR) and 95% CIs using a fixed effects model. Results: A total of 116,342 and 360 elderly patients from five cohort studies and two randomized clinical trials (RCTs) were included for analysis. The pooled incidences of symptomatic congestive heart failure (CHF) and CHF/HF/CM were 6.4% (95% CI 4.1% – 9.4) and 16.4% (95% CI 16.19% – 16.61) in patients with median age of 67.5 years from two RCTs and in patients with median age of 67.5 (60 – 75), 71 (66 – 80+), 74.5 (65 – 89), 75 (66 – 81+) and 79.5 (60 – 99) from five cohort studies, respectively. Trastuzumab was significantly correlated with an increased risk of defined cardiac toxicities in five cohort studies (HR = 1.89, 95% CI 1.72 – 2.07, p < 0.00001) and two RCTs (HR = 3.00, 95% CI 1.71, 5.26, p < 0.00001). Sub-group analysis showed that the anthracycline-based chemotherapy increased the risk of CHF/HF and CM in patients among five cohort studies (HR = 2.16, 95% CI: 1.8 – 1.87, p < 0.00001). Conclusion: Trastuzumab is likely associated with an increased risk of cardiac toxicity in elderly patients with HER-2-positive breast cancer. Carefully monitoring cardiac function in elderly patients receiving trastuzumab, particularly with concurrent use of anthracycline, is warranted.
Twenty years of local farmland bird conservation: the effects of management on avian abundance at two UK demonstration sites
Creators: name: Aebischer, Nicholas J.
name: Bailey, Chris M.
name: Gibbons, David W.
name: Morris, Antony J.
name: Peach, Will J.
name: Stoate, Chris
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Capsule At two demonstration farms, Game & Wildlife Conservation Trust's Loddington Farm in Leicestershire and Royal Society for the Protection of Birds's Hope Farm in Cambridgeshire, targeted management led to much faster increases in avian abundance than in the surrounding regions. Aims To compare changes in avian abundance at Loddington Farm since 1992 and Hope Farm since 2000, and relate these to regional trends in bird abundance and to the habitat and predator management conducted at the two sites. Methods Loddington Farm is a mixed arable 292-ha farm in a partially wooded landscape in Leicestershire. It was managed as a shoot from 1993 to 2002, combining habitat management with predator control (stopped in 2002) and winter grain provision (ceased in 2006). Hope Farm comprises a 181-ha mainly arable farm in an open landscape in Cambridgeshire, where habitat management for farmland birds has taken place since 2002. At both sites, breeding bird abundance has been monitored annually. Information on farm management was translated into three variables measuring annual provision of nesting cover, summer food and winter food. The number of Carrion Crow and Magpie territories was used as an index of predator abundance. Results Avian abundance increased at both farms much faster than within their respective regions. Recovery of priority species was positively correlated with the provision of summer foraging habitats and negatively correlated with the provision of supplementary grain during winter. The latter finding was counterintuitive and may reflect an increase in hedgerow provision that coincided with the cessation of grain provision at both farms. The increase in bird abundance was not sustained at Loddington Farm in the absence of predator control, although it was at Hope Farm where predator densities were markedly lower. Conclusion The data from Hope Farm suggest that where predator densities are relatively low (<3 Crow + Magpie pairs/km2 locally, <0.2 Foxes/km2 in spring regionally), recovery of farmland birds can be achieved through habitat management alone. Where predator densities are high (>5 corvid pairs/km2 and >1.1 foxes/km2), as at Loddington Farm, species recovery, particularly of open-cup nesting species, may require predator control as well as habitat management. Further study is needed to confirm this tentative conclusion from only two sites.
Academic Search Engine Optimization - Heuristics
Creators: name: TREVISAN, Gustavo LUNARDELLI
Publisher: name: Zenodo
Year: 2022
Subjects: ASEO
Academic Search Engine Optimization
Heuristics ASEO

description: Apresenta-se um conjunto de Heurísticas ASEO, agrupadas em 3 dimensões e 6 etapas, prontas para serem avaliadas por Autores, Instituições e Editoras. As Heurísticas ASEO tem por referência construtiva as recomendações de Abby Covert (2020), onde a autora elabora um compêndio heurístico, estabelecendo diretrizes as quais o desenvolvedor de um produto e/ou serviços destinados ao usuário sejam pensados à perspectiva do usuário, Nielsen e Molich (1990), que trata da Heurísticas de Usabilidade, Morville e Rosenfeld (2004), que abordam as heurísticas de Arquitetura da Informação, Resmini e Rosati (2011), que introduzem as heurísticas da Arquitetura da Informação Pervasiva e por fim, Codina e Lopeloza (2020), compiladas e delineadas na representação visual a seguir:
description: Anexo Tese
Twenty years of local farmland bird conservation: the effects of management on avian abundance at two UK demonstration sites
Creators: name: Aebischer, Nicholas J.
name: Bailey, Chris M.
name: Gibbons, David W.
name: Morris, Antony J.
name: Peach, Will J.
name: Stoate, Chris
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Capsule At two demonstration farms, Game & Wildlife Conservation Trust's Loddington Farm in Leicestershire and Royal Society for the Protection of Birds's Hope Farm in Cambridgeshire, targeted management led to much faster increases in avian abundance than in the surrounding regions. Aims To compare changes in avian abundance at Loddington Farm since 1992 and Hope Farm since 2000, and relate these to regional trends in bird abundance and to the habitat and predator management conducted at the two sites. Methods Loddington Farm is a mixed arable 292-ha farm in a partially wooded landscape in Leicestershire. It was managed as a shoot from 1993 to 2002, combining habitat management with predator control (stopped in 2002) and winter grain provision (ceased in 2006). Hope Farm comprises a 181-ha mainly arable farm in an open landscape in Cambridgeshire, where habitat management for farmland birds has taken place since 2002. At both sites, breeding bird abundance has been monitored annually. Information on farm management was translated into three variables measuring annual provision of nesting cover, summer food and winter food. The number of Carrion Crow and Magpie territories was used as an index of predator abundance. Results Avian abundance increased at both farms much faster than within their respective regions. Recovery of priority species was positively correlated with the provision of summer foraging habitats and negatively correlated with the provision of supplementary grain during winter. The latter finding was counterintuitive and may reflect an increase in hedgerow provision that coincided with the cessation of grain provision at both farms. The increase in bird abundance was not sustained at Loddington Farm in the absence of predator control, although it was at Hope Farm where predator densities were markedly lower. Conclusion The data from Hope Farm suggest that where predator densities are relatively low (<3 Crow + Magpie pairs/km2 locally, <0.2 Foxes/km2 in spring regionally), recovery of farmland birds can be achieved through habitat management alone. Where predator densities are high (>5 corvid pairs/km2 and >1.1 foxes/km2), as at Loddington Farm, species recovery, particularly of open-cup nesting species, may require predator control as well as habitat management. Further study is needed to confirm this tentative conclusion from only two sites.
Anomalies in the Process of Ionization of Analytes in MALDI: Electronic Transfer Vs. Proton Transfer Via Quantum Chemistry
Creators: name: Álvarez, María J.
name: Sánchez, Luis Miguel Díaz
name: Montañez, Marianny Yajaira Combariza
name: Tirado, Cristian Blanco
name: Montañez, Aldo Fabrizzio Combariza
Publisher: name: Zenodo
Year: 2022

description: Matrix-Assisted Laser Ionization/Desorption (MALDI) makes possible to ionize any target molecule (with low or high molecular weight and/or with low or high concentration) indirectly, mediated by analyte interaction with with an organic compound that serves as a matrix. The FisicoQuímica Teórica y Experimental (GIFTEX) Research Group of the Universidad Industrial de Santander (UIS) have been working for years on the development of MALDI matrices for the analysis of a broad spectrum of chemical species. Matrixes developed by GIFTEX-RG, such as 𝛼-cyanophenylenevinylene (𝛼-CNFV), are suggested as better analytical medators than commercial matrices, such as DCTB. Therefore, we propose the use of mechano-quantum methods to calculate physical-chemical parameters of the compounds involved in the study (matrixes and analytes) to evaluate CNFV as possible Proton Transfer (PT) matrices. The first step is to obtain the geometries of matrix and analyte structures, followed by geometry optimization, using the quantum chemistry software ORCA, both in neutral and protonic chemical state. Geometry optimizations will be performed using ab initio (RHF/6-311G(2d,2p)) and DFT (B3LYP/6-311G(2d,2p)) theory levels. Later on, the system energy and the most favorable protonation site will be evaluated. Calculations will be performed in gaseous phase, subtracting the energy difference between the neutral optimised structure and the protonate optimised structure. The results will be analyzed to explain the anomalous protonation of analytes using electron transfer matrices.
Amendment and Modification of Treaties-An Overview 24-Apr-2022 13-59-25.pdf
Creators: name: Ekpo, Mokutima  Etido
Publisher: name: figshare
Year: 2022
Subjects: subject: 180104 Civil Law and Procedure
subject: FOS: Law

description: Amendment and modification of treaties are terms provided for by the Vienna Convention, (the Convention) 1969 even though they are not defined thereto. Like a treaty, they are also international agreements but the distinctive factor here is that amendment and modifications occur only in multilateral treaties...
Rethinking Independent Cross-Entropy Loss For Graph-Structured Data
Creators: name: Miao, Rui
name: Zhou, Kaixiong
name: Wang, Yili
name: Liu, Ninghao
name: Wang, Ying
name: Wang, Xin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Graph neural networks (GNNs) have exhibited prominent performance in learning graph-structured data. Considering node classification task, based on the i.i.d assumption among node labels, the traditional supervised learning simply sums up cross-entropy losses of the independent training nodes and applies the average loss to optimize GNNs' weights. But different from other data formats, the nodes are naturally connected. It is found that the independent distribution modeling of node labels restricts GNNs' capability to generalize over the entire graph and defend adversarial attacks. In this work, we propose a new framework, termed joint-cluster supervised learning, to model the joint distribution of each node with its corresponding cluster. We learn the joint distribution of node and cluster labels conditioned on their representations, and train GNNs with the obtained joint loss. In this way, the data-label reference signals extracted from the local cluster explicitly strengthen the discrimination ability on the target node. The extensive experiments demonstrate that our joint-cluster supervised learning can effectively bolster GNNs' node classification accuracy. Furthermore, being benefited from the reference signals which may be free from spiteful interference, our learning paradigm significantly protects the node classification from being affected by the adversarial attack.
description: 20 pages, 4 figures
A Conscious Creation? Political Economy, Globalisation and Cultural Representation in Terrestrial South Korean Miniseries 2002-2017
Creators: name: Lewis, Rebecca
Publisher: name: University of Westminster
Year: 2024

description: This thesis seeks to determine the extent to which miniseries broadcast across three Korean terrestrial public and commercial networks - KBS, MBC, and SBS - between 2002 and 2017 suitably reflect Korean culture and society. It investigates the changes in common cultural themes and representations across this period, unravelling the complex relationship between business, culture, and the evolution of content within this media form.

The contribution to knowledge of this research rests on its methods: the employment of a dual-strand approach of critical political economy and cultural studies. The critical political economy component relies on twelve semi-structured interviews with professionals working across policy, production and distribution. By examining political and economic dynamics at play, the thesis dissects influences and catalysts that have driven changes in the industry and the attributes of decision-making across the life course of the television drama.

The cultural studies strand examines cultural representation through a critical discourse analysis of 57 dramas (KBS - 24, MBC - 16, SBS - 17), varying between one in 2002 to seven in 2015 (average 3.5 per year), to identify larger trends over a broad period. The data was gathered through a coding method derived from Hofstede’s six cultural dimensions and connected to three cultural perspectives - nationalist, neoliberal capitalist, and postcolonial/translocal regionalist (Cho Hae Joang, 2005; Lee Kee Hyeung, 2006; Cho Young Han, 2011) - to assess cultural representation and identify its permutations and revisions.

My hypothesis postulates the Korean miniseries presents idealised versions of cultural conservatism and economic capitalism which have shifted towards cultural progression and capitalist critique over the period of study; a shift ascribed to processes of globalisation, cultural hybridisation, and the pursuit of international audiences. However, my findings conclude that observed changes are likely not a premeditated shift towards progressivism, but rather an outcome of neoliberalism and cultural exchange. In particular, as per political economy insights, difficulty in securing funding compels both production houses and networks to stick to time-proven narratives and characterisations, whilst the competition for revenue and airtime perpetuates the tension of prioritising profit over promoting national culture, ultimately determining the direction of content development.

This research enhances our understanding of the intricate connections between business, cultural identity, and content in the Korean miniseries format. It provides valuable insights into cultural identity, themes, representation, and economic forces that have shaped the evolution of this popular media format, shedding light on the broader societal and economic implications within the Korean context.
A Critical Evaluation of the use of force by the United Nations Security Council 24-Apr-2022 10-01-27.pdf
Creators: name: Ekpo, Mokutima  Etido
Publisher: name: figshare
Year: 2022
Subjects: subject: 180119 Law and Society
subject: FOS: Law

description: The use of force by the security council, thought to be substantive in nature in order to attain the major goal of the United Nations, has been politicized especially by the five permanent members...
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The Minimal Dataset for Cancer of the 1+Million Genomes Initiative
Creators: name: Riba, Michela
name: Sala, Cinzia
name: Culhane, Aedin
name: Flobak, Asmund
name: Patocs, Attila
name: Boye, Kjetil
name: Plevova, Karla
name: Pospisilova, Sarka
name: Gandolfi, Giorgia
name: Morelli, Marco
name: Bucci, Gabriele
name: Edsjö, Anders
name: Lassen, Ulrik
name: Al-Shahrour, Fátima
name: Lopez-Bigas, Nuria
name: Hovland, Randi
name: Cuppen, Edwin
name: Valencia, Alfonso
name: Antoine-Poirel, Helene
name: Rosenquist, Richard
name: Scollen, Serena
name: Arenas Marquez, Juan
name: Belien, Jeroen
name: De Nicolo, Arcangela
name: De Maria, Ruggero
name: Torrents, David
name: Tonon, Giovanni
Publisher: name: Zenodo
Year: 2024

description: For a real impact on healthcare, precision cancer medicine requires accessibility and interoperability of clinical and genomic data across centres and countries. Due to the   heterogeneous digitization in Europe and worldwide, the definition of models for standardised data collection and usability becomes mandatory if countries want to work together on this mission. The European Union 1+Million Genomes (1+MG) initiative, supported by the Horizon 2020 Beyond 1 Million Genome project, aims at outlining data models, guidance, best practices, and technical infrastructures for transnational access to sequenced genomes, including cancer genomes. Within the framework of the cancer-focused Working Group 9 (WP9), we developed the 1+MG-Minimal Dataset for Cancer (1+MG-MDC)–a data model encompassing 138 items and organized in eight conceptual domains, for the collection of cancer-related clinical information and genomics metadata. The 1+MG-MDC, which is the result of a multidisciplinary effort, leverages pre-existing models and emphasizes the annotation and traceability of multiple aspects relevant to the complex longitudinal path of the cancer disease and its treatment. We strived to make 1+MG-MDC easy to adopt and to be filled in, and yet comprehensive, addressing the needs of both clinicians and researchers. It will be periodically revisited and updated by the 1+MG WG9 to ensure it remains fit for purpose. We propose it as a model to create homogeneous databases, which would, in turn, guide discussions on clinical and genomic features with prognostic or therapeutic value and foster real-world data research.
Development and characterization of functionalized Al2O3 and TiO2-reinforced polybenzoxazine nanocomposites
Creators: name: T. Lakshmikandhan
name: A. Chandramohan
name: K. Sethuraman
name: M. Alagar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Molecular Biology
subject: Medicine
subject: Physics
subject: Engineering

description: In the present work, benzoxazine was synthesized using caprolactam amine and cardanol, and its molecular structure was confirmed with FTIR and NMR spectroscopic techniques. Alumina (Al2O3) and titania (TiO2) were functionalized using 3-aminopropyltrimethoxysilane (APTMS). The nanocomposites were developed by reinforcing with varying weight (1, 3, 5, and 7) percentages of functionalized Al2O3 (F-Al2O3) and functionalized TiO2 (F-TiO2) with benzoxazine. The developed nanocomposites (F-Al2O3/CPBz and F-TiO2/CPBz) were characterized from their thermal, dielectric, and UV shielding studies. Data obtained from thermal studies show that 7 wt% of F-Al2O3-reinforced cardanol-based polybenzoxazine nanocomposite exhibits higher thermal stability than that of 7 wt% F-TiO2-reinforced cardanol-based polybenzoxazine nanocomposite. Dielectric and UV shielding studies show that 7 wt% F-TiO2 nanocomposite show higher value of dielectric constant (10.2) and UV shielding value (93%) than those of neat and other weight percentages of F-Al2O3 and F-TiO2 reinforced composites.
The Minimal Dataset for Cancer of the 1+Million Genomes Initiative
Creators: name: Riba, Michela
name: Sala, Cinzia
name: Culhane, Aedin
name: Flobak, Asmund
name: Patocs, Attila
name: Boye, Kjetil
name: Plevova, Karla
name: Pospisilova, Sarka
name: Gandolfi, Giorgia
name: Morelli, Marco
name: Bucci, Gabriele
name: Edsjö, Anders
name: Lassen, Ulrik
name: Al-Shahrour, Fátima
name: Lopez-Bigas, Nuria
name: Hovland, Randi
name: Cuppen, Edwin
name: Valencia, Alfonso
name: Antoine-Poirel, Helene
name: Rosenquist, Richard
name: Scollen, Serena
name: Arenas Marquez, Juan
name: Belien, Jeroen
name: De Nicolo, Arcangela
name: De Maria, Ruggero
name: Torrents, David
name: Tonon, Giovanni
Publisher: name: Zenodo
Year: 2023

description: For a real impact on healthcare, precision cancer medicine requires accessibility and interoperability of clinical and genomic data across centres and countries. Due to the heterogeneous digitization in Europe and worldwide, the definition of models for standardised data collection and usability becomes mandatory if countries want to work together on this mission. The European Union 1+Million Genomes (1+MG) initiative, supported by the Horizon 2020 Beyond 1 Million Genome project, aims at outlining data models, guidance, best practices, and technical infrastructures for transnational access to sequenced genomes, including cancer genomes. Within the framework of the cancer-focused Working Group 9 (WP9), we developed the 1+MG-Minimal Dataset for Cancer (1+MG-MDC)–a data model encompassing 138 items and organized in eight conceptual domains, for the collection of cancer-related clinical information and genomics metadata. The 1+MG-MDC, which is the result of a multidisciplinary effort, leverages pre-existing models and emphasizes the annotation and traceability of multiple aspects relevant to the complex longitudinal path of the cancer disease and its treatment. We strived to make 1+MG-MDC easy to adopt and to be filled in, and yet comprehensive, addressing the needs of both clinicians and researchers. It will be periodically revisited and updated by the 1+MG WG9 to ensure it remains fit for purpose. We propose it as a model to create homogeneous databases, which would, in turn, guide discussions on clinical and genomic features with prognostic or therapeutic value and foster real-world data research.
Potency and pharmacokinetics of broad spectrum and isoform-specific p110γ and δ inhibitors in cancers
Creators: name: Aravind Setti
name: M. J. Vijay Kumar
name: K. Ravi Babu
name: A. Rasagna
name: M. G. R. Devi Prasanna
name: T. A. Phazna Devi
name: Pawar, Smita C.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Emerging data on cancer suggesting that target-based therapy is promising strategy in cancer treatment. PI3K-AKT pathway is extensively studied in many cancers; several inhibitors target this pathway in different levels. Recent finding on this pathway uncovered the therapeutic applications of PI3K-specific inhibitors; PI3K, AKT, and mTORC broad spectrum inhibitors. Noticeably, class I PI3K isoforms, p110γ and p110δ catalytic subunits have rational therapeutic application than other isoforms. Therefore, three classes of inhibitors: isoform-specific, dual-specific and broad spectrum were selected for molecular docking and dynamics. First, p110δ structure was modelled; active site was analyzed. Then, molecular docking of each class of inhibitors were studied; the docked complexes were further used in 1.2 ns molecular dynamics simulation to report the potency of each class of inhibitor. Remarkably, both the studies retained the similar kind of protein ligand interactions. GDC-0941, XL-147 (broad spectrum); TG100-115 (dual-specific); and AS-252424, PIK-294 (isoform-specific) were found to be potential inhibitors of p110γ and p110δ, respectively. In addition to that pharmacokinetic properties are within recommended ranges. Finally, molecular phylogeny revealed that p110γ and p110δ are evolutionarily divergent; they probably need separate strategies for drug development.
Potency and pharmacokinetics of broad spectrum and isoform-specific p110γ and δ inhibitors in cancers
Creators: name: Aravind Setti
name: M. J. Vijay Kumar
name: K. Ravi Babu
name: A. Rasagna
name: M. G. R. Devi Prasanna
name: T. A. Phazna Devi
name: Pawar, Smita C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Emerging data on cancer suggesting that target-based therapy is promising strategy in cancer treatment. PI3K-AKT pathway is extensively studied in many cancers; several inhibitors target this pathway in different levels. Recent finding on this pathway uncovered the therapeutic applications of PI3K-specific inhibitors; PI3K, AKT, and mTORC broad spectrum inhibitors. Noticeably, class I PI3K isoforms, p110γ and p110δ catalytic subunits have rational therapeutic application than other isoforms. Therefore, three classes of inhibitors: isoform-specific, dual-specific and broad spectrum were selected for molecular docking and dynamics. First, p110δ structure was modelled; active site was analyzed. Then, molecular docking of each class of inhibitors were studied; the docked complexes were further used in 1.2 ns molecular dynamics simulation to report the potency of each class of inhibitor. Remarkably, both the studies retained the similar kind of protein ligand interactions. GDC-0941, XL-147 (broad spectrum); TG100-115 (dual-specific); and AS-252424, PIK-294 (isoform-specific) were found to be potential inhibitors of p110γ and p110δ, respectively. In addition to that pharmacokinetic properties are within recommended ranges. Finally, molecular phylogeny revealed that p110γ and p110δ are evolutionarily divergent; they probably need separate strategies for drug development.