cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Magnetic resonance imaging of pancreatitis: An update
Creators: name: Busireddy, Kiran K.
name: Nilmini, Viragi
name: Semelka, Richard C.
name: Alagiyawanna, Madhavi
name: Manikkavasakar, Sriluxayini
name: Ramalho, Miguel
name: AlObaidy, Mamdoh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Magnetic resonance (MR) imaging plays an important role in the diagnosis and staging of acute and chronic pancreatitis and may represent the best imaging technique in the setting of pancreatitis due to its unmatched soft tissue contrast resolution as well as non-ionizing nature and higher safety profile of intravascular contrast media, making it particularly valuable in radiosensitive populations such as pregnant patients, and patients with recurrent pancreatitis requiring multiple follow-up examinations. Additional advantages include the ability to detect early forms of chronic pancreatitis and to better differentiate adenocarcinoma from focal chronic pancreatitis. This review addresses new trends in clinical pancreatic MR imaging emphasizing its role in imaging all types of acute and chronic pancreatitis, pancreatitis complications and other important differential diagnoses that mimic pancreatitis.
(401371) Henry Lea
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 11 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11: Table S3. Cell wall subcategories induced during DH and RH.
Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease
Creators: name: Boyle, Brendan M.
name: Milov, David E.
name: Colletti, Richard B.
name: Kappelman, Michael D.
name: Crandall, Wallace V.
name: Baldassano, Robert N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: AIM: To evaluate the effectiveness of thiopurines in maintaining steroid-free remission in routine clinical practice.
Stable and unstable Einstein warped products
Creators: name: Kroencke, Klaus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 58J05, 53C25, 53C21

description: In this article, we systematically investigate the stability properties of certain warped product Einstein manifolds. We characterize stability of these metrics in terms of an eigenvalue condition of the Einstein operator on the base manifold. In particular, we prove that all complete manifolds carrying imaginary Killing spinors are strictly stable. Moreover, we show that Ricci-flat and hyperbolic cones over Kähler-Einstein Fano manifolds and over nonnegatively curved Einstein manifolds are stable if the cone has dimension $n\geq10$.
description: 26 pages, published version
N-acetylcysteine treats intravenous amiodarone induced liver injury
Creators: name: Mudalel, Matthew L.
name: Solga, Steven F.
name: Dave, Kartikeya P.
name: Humme, James P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.
Distractor filtering in the visual attention domain: evidence for habituation of attentional capture.
Creators: name: Bonetti, Francesca
Publisher: name: Universit� degli studi di Trento
Year: 2019

description: In everyday life, we are constantly surrounded by a huge amount of information.Since our attentional resources are limited, we need to select just the stimuli that we want to process. Despite our voluntary attempt to select a precise information, it often occurs that a salient stimulus or event automatically captures our attention, regardless its irrelevance. The fact that we are immediately and unintentionally attracted by sudden visual onsets provides a clear advantage for our survival. However, in spite of that, the possibility to counteract visual distraction is fundamental for an efficient interaction with the environment, particularly when a salient but irrelevant stimulation repeatedly affects our visual system. And then, how can we resist from being continuously distracted by irrelevant repetitive onsets? The current work is aimed to explore the mechanisms that we use to filter irrelevant information, with a focus on habituation, an ancestral form of learning that has recently been associated to the decrement of attentional capture observed in several studies. This experience-dependent learning process is defined as a behavioral response decrement that results from repeated stimulation and that does not involve sensory or motor fatigue. I will first provide the reader with a general introduction (Chapter 1) concerning the visual attention field, with a particular emphasis on attentional capture and the filtering of irrelevant information. I will then (Chapter 2) try to disentangle the two main accounts concerning the nature of the distractor filtering, the first claiming that filtering is accomplished to shield target processing from interference (top-down inhibitory control hypothesis), and the second stating that the passive exposure to a repeating visual onset is sufficient to trigger learning-dependent mechanisms to filter the unwanted stimulation (habituation hypothesis). After providing strong evidence in favor of the latter account, I will then examine (Chapter 3) to what extent the filtering of irrelevant information that we achieve through the mechanisms underlying habituation is affected by contextual cues, showing that this kind of filtering is context-dependent. Finally (Chapter 4), motivated by the existence of a strong functional and anatomical link between attention and the oculomotor system, I will explore whether habituation affects also the oculomotor capture triggered by an onset distractor, showing that the execution of reflexive saccades is subject to habituation, while the programming component is not. Taken together, the results of the present work give a strong contribution to the attentional capture field in showing that both attentional and oculomotor capture are subject to habituation, that this form of learning is context-specific and that it occurs also when we are passively exposed to a visual irrelevant stimulus.
Outcome of stenting in biliary and pancreatic benign and malignant diseases: A comprehensive review
Creators: name: Mangiavillano, Benedetto
name: Luigiano, Carmelo
name: Baron, Todd H.
name: Pagano, Nico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Endoscopic stenting has become a widely method for the management of various malignant and benign pancreatico-biliary disorders. Biliary and pancreatic stents are devices made of plastic or metal used primarily to establish patency of an obstructed bile or pancreatic duct and may also be used to treat biliary or pancreatic leaks, pancreatic fluid collections and to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis. In this review, relevant literature search and expert opinions have been used to evaluate the outcome of stenting in biliary and pancreatic benign and malignant diseases.
Personalized targeted therapy for esophageal squamous cell carcinoma
Creators: name: Chen, Xiaoxin
name: D'Amico, Thomas A.
name: Chen, Keneng
name: Li, Yicheng
name: Kang, Xiaozheng
name: Li, Jianying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.
title: Ovarian masses: MRI imaging and differential diagnosis.
Creators: name: Choayb, Safaa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Imaging sequences
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: LEARNING OBJECTIVE: Recognize the role of MRI in differentiation between benign and malign ovarian tumors. Illustrate characteristic imaging findings helpful in the diagnosis of certain ovarian...
Additional file 2 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Morphology and RNA integrity of S. lepidophylla and S. denticulata during the desiccation process.
Le forme del narrare: nel tempo e tra i generi (vol. I - Lingua)
Creators: name: Liverani, Elena Maria
name: Carpi, E.
name: Garcia Jimenez
name: R., M.
Publisher: name: Dipartimento di lettere e filosofia - Universit� degli Studi di Trento
Year: 2016

description: Il presente volume raccoglie una selezione di interventi che vertono su ?Le forme del narrare: nel tempo e tra i generi?; l?occa�sione che ha permesso a diversi studiosi italiani e spagnoli di riflettere proficuamente sull?argomento � stata il convegno del�l?Associazione degli ispanisti italiani svoltosi a Pisa nel novembre del 2013. In particolare sono qui riunite le riflessioni di taglio linguistico che declinano tale linea tematica, offrendo un ventaglio di proposte d?analisi di testi letterari e non solo, dal punto di vista della tipologia testuale della narrazione. Gli importanti contributi delle diverse teorie e metodologie linguistiche convergono qui intrecciandosi con nuove suggestioni scientifiche non prive di affondi multidisciplinari che lasciano ampio spazio anche alle indagini sui fenomeni dell?oralit� nei testi scritti, compresi quelli veicolati da supporti digitali, e nelle narrazioni propriamente orali.
From optimization to listing: theoretical advances in some enumeration problems
Creators: name: Raffaele, Alice
Publisher: name: Universit� degli studi di Trento
Year: 2022

description: The main aim of this thesis is to investigate some problems relevant in enumeration and optimization, for which I present new theoretical results. First, I focus on a classical enumeration problem in graph theory with several applications, such as network reliability. Given an undirected graph, the objective is to list all its bonds, i.e., its minimal cuts. I provide two new algorithms, the former having the same time complexity as the state of the art by [Tsukiyama et al., 1980], whereas the latter offers an improvement. Indeed, by refining the branching strategy of [Tsukiyama et al., 1980] and relying on some dynamic data structures by [Holm et al., 2001], it is possible to define an eO(n)-delay algorithm to output each bond of the graph as a bipartition of the n vertices. Disregarding the polylogarithmic factors hidden in the eO notation, this is the first algorithm to list bonds in a time linear in the number of vertices. Then, I move to studying two well-known problems in theoretical computer science, that are checking the duality of two monotone Boolean functions, and computing the dual of a monotone Boolean function. Also these are relevant in many fields, such as linear programming. [Fredman and Khachiyan, 1996] developed the first quasi-polynomial time algorithm to solve the decision problem, thus proving that it is not coNP-complete. However, no polynomial-time algorithm has been discovered yet. Here, by focusing on the symmetry of the two input objects and exploiting full covers introduced by [Boros and Makino, 2009], I define an alternative decomposition approach. This offers a strong bound which, however, in the worst case, is still the same as [Fredman and Khachiyan, 1996]. Anyway, I also show how to adapt it to obtain a polynomial-space algorithm to solve the dualization problem. Finally, as extra content, this thesis contains an appendix about the topic of communicating operations research. By starting from two side projects not related to enumeration, and by comparing some relevant considerations and opinions by researchers and practitioners, I discuss the problem of properly promoting, fostering, and communicating findings in this research area to laypeople.
Psychosocial mechanisms for the transmission of somatic symptoms from parents to children
Creators: name: Walker, Lynn S.
name: Garner, Michelle
name: Van Tilburg, Miranda A.L.
name: Feld, Lauren D.
name: Whitehead, William E.
name: Levy, Rona L.
name: Von Korff, Michael
name: Feld, Andrew D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AIM: To examine familial aggregation of irritable bowel syndrome (IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.
(401372) Louise [Lea]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Bowel wall thickening and differential diagnosis of colitis.
Creators: name: Perez, Vanessa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: CT
subject: Contrast agent-intravenous
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Mural thickening of the bowel loops is a frequent but very unspecific finding in CT. It is important to know the different parameters to be analyzed and to perform a systematic reading to guide the most probable diagnosis. Before assessing the...
Path-Integral Approach to Scale Anomaly at Finite Temperature
Creators: name: Lin, Chris L.
name: Ordonez, Carlos R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive the relativistic thermodynamic scale equation using imaginary-time path integrals, with complex scalar field theory taken as a concrete example. We use Fujikawa's method to derive the scaling anomaly for this system using a matrix regulator. We make a general scaling argument to show how for anomalous systems, the $β$ function of the vacuum theory can be derived from measurement of macroscopic thermodynamic parameters.
description: 10 pages (this version is the published version)
(De-)mentalization and objectification processes towards minority groups: When the human-object divide fades.
Creators: name: Ruzzante, Daniela
Publisher: name: Universit� degli studi di Trento
Year: 2022

description: While cutting-edge research has shown how ? from a neural and cognitive point of view ? human beings are perceived and elaborated differently from objects, in social psychology different studies demonstrated that this human-object divide fades in several circumstances. Research in social psychology is continuing to advance the knowledge on dehumanization and objectification phenomenon in which human beings are perceived and elaborated more similar to an object and less like a human being. Recently, this has been demonstrated quite literally directly comparing human stimuli with a mind and perceptually similar mindless objects (Vaes et al., 2019, 2020). Such direct comparisons allow us to demonstrate how the well-documented human-object divide tends to fade during dehumanization and objectification phenomena. Presenting five research studies, this thesis aims not only at proving how de-mentalized human stimuli are cognitively perceived as object-like (Chapter 2 and 3), but also at showing how these phenomena are influencing more subtle, un-controlled behaviour processes that impact human social interactions (Chapter 4). Specifically, in Chapter 2, two similar EEG studies aimed at exploring the timeline of the mentalization process by adapting a paradigm in which the human-object divide is investigated. By manipulating both perceptual and contextual information, ingroup and outgroup human faces together with their identity-matched doll-like avatar faces were presented while registering participants? neural correlates. Thanks to the direct comparison between mindless and mindful targets our goal was to unravel the time course of mentalization and its underlying processes. By adapting the same paradigm, in Chapter 3 we explored the process of sexual objectification and presented sexually objectified men and women with their gender-matched doll-like avatars. Our primary goal was to investigate how objectified men and women are perceptually and cognitive perceived by looking at a sample of gay men. By directly comparing mindless and mindful targets we wanted to understand whether sexual objectification might be target (i.e., always mainly directed towards women regardless of the perceivers sexual orientation) or agent specific (i.e., directed towards different targets depending on the perceivers sexual orientation). Moreover, we also wanted to explore what might drive heterosexual men and women and gay men to objectify others. Finally, the purpose of Chapter 4 was to investigate an implicit and unconscious consequence of sexual objectification. By presenting objectified and non-objectified women expressing happiness and anger we measured participants? spontaneous mimicry responses. Our goal was to determine whether sexual objectification ? a phenomenon in which women are considered as object-like ? might influence such an uncontrolled and implicit human behaviour that affects normal social interactions.
Persistent mechanical linkage between sister chromatids throughout anaphase
Creators: name: Bloom, Kerry
name: Harrison, Benjamin D.
name: Hoang, Margaret L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In budding yeast, we have found that sister rDNA arrays marked with fluorescent probes can be visualized as two distinguishable strands during metaphase. Upon anaphase, these arm loci are drawn into the spindle, where they adopt a cruciform-like structure and stretch 2.5-fold as they migrate to the poles. Therefore, while sister rDNA arrays appear separated in metaphase, mechanical linkages between sister arm loci persist throughout anaphase in yeast, as shown in grasshopper spermatocytes (Paliulis and Nicklas 2004). These linkages are partially dependent on the protector of cohesin, SGO1. In anaphase, the spatially regulated dissolution of these mechanical linkages serves to prevent premature sister separation and restrain the rate of spindle elongation. Thus, sister separation is temporally controlled and linkages between sister chromatids contribute to the regulation of anaphase spindle elongation.
On membrane interactions and a three-dimensional analog of Riemann surfaces
Creators: name: Kovacs, Stefano
name: Sato, Yuki
name: Shimada, Hidehiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Membranes in M-theory are expected to interact via splitting and joining processes. We study these effects in the pp-wave matrix model, in which they are associated with transitions between states in sectors built on vacua with different numbers of membranes. Transition amplitudes between such states receive contributions from BPS instanton configurations interpolating between the different vacua. Various properties of the moduli space of BPS instantons are known, but there are very few known examples of explicit solutions. We present a new approach to the construction of instanton solutions interpolating between states containing arbitrary numbers of membranes, based on a continuum approximation valid for matrices of large size. The proposed scheme uses functions on a two-dimensional space to approximate matrices and it relies on the same ideas behind the matrix regularisation of membrane degrees of freedom in M-theory. We show that the BPS instanton equations have a continuum counterpart which can be mapped to the three-dimensional Laplace equation through a sequence of changes of variables. A description of configurations corresponding to membrane splitting/joining processes can be given in terms of solutions to the Laplace equation in a three-dimensional analog of a Riemann surface, consisting of multiple copies of R^3 connected via a generalisation of branch cuts. We discuss various general features of our proposal and we also present explicit analytic solutions.
description: 64 pages, 17 figures. V2: An appendix, a figure and references added; various minor changes and improvements
Additional file 12 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12. Morphological identification, habitat description and coordinates.
Additional file 3 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. Size distribution of desiccation responsive transcripts and their annotation.
Mapping the mouse connectome with voxel resolution
Creators: name: Coletta, Ludovico
Publisher: name: Universit� degli studi di Trento
Year: 2022

description: Fine-grained descriptions of brain connectivity are required to understand how neural information is processed and relayed across spatial scales. Prior investigations of the mouse brain connectome have employed discrete anatomical parcellations, limiting spatial resolution and potentially concealing network attributes critical to connectome organization. In this work, we provide a voxel-level description of the network and hierarchical structure of the directed mouse connectome, unconstrained by regional partitioning. We found that hub regions and core network components of the voxel-wise mouse connectome exhibit a rich topography encompassing key cortical and subcortical relay regions. We also typified regional substrates based on their directional topology into sink or source regions, and reported a previously unappreciated role of modulatory nuclei as critical effectors of inter-modular and network communicability. Finally, we demonstrated a close spatial correspondence between the mesoscale topography of the mouse connectome and its functional macroscale organization, showing that, like in primates and humans, the mouse cortical connectome is organized along two major topographical axes that can be linked to hierarchical patterns of laminar connectivity, and shape the topography of fMRI dynamic states, respectively. This investigation was paralleled by further studies aimed to more closely relate structural connectome features to the corresponding large scale functional networks of the mouse brain. We first focused on the mouse default mode network (DMN), describing its axonal substrates with sublaminar precision and cell-type specificity. We found that regions of the mouse DMN are predominantly located within the isocortex and exhibit preferential connectivity. Dedicated tract tracing experiments carried out by the Allen Brain Institute revealed that layer 2/3 DMN neurons projected mostly in the DMN, whereas layer 5 neurons project both in and out. Further analyses revealed the presence of separate in-DMN and out-DMN-projecting cell types with distinct genetic profiles. Lastly, we carried out a fine-grained comparison of functional topography and dynamic organization of large-scale fMRI networks in wakeful and anesthetized mice, relating the corresponding functional networks to the underlying architecture of structural connectivity. Recapitulating prior observations in conscious primates, we found that the awake mouse brain is subjected to a profound topological reconfiguration such to maximize cross-talk between cortical and subcortical neural systems, departing from the underlying structure of the axonal connectome. Taken together, these results advance our understanding of the foundational wiring principles of the mammalian connectome, and create opportunities for identifying targets of interventions to modulate brain function and its network structure in a physiologically-accessible species.
Effective field theory description of ? cluster nuclei: The 9 Be ground state and 9 Be photodisintegration
Creators: name: Filandri, Elena
Publisher: name: Universit� degli studi di Trento
Year: 2022

description: In this Thesis we present a description of ? cluster nuclei, in particular focusing on the case of 9 Be, with ?n and ?? interactions derived from Cluster Effective Field Theory (EFT). The two-body potentials are regularized by a Gaussian cutoff which cures the short-distance dependence of the interaction and the potential parameters are found comparing the effective range expansion (ERE) with the calculated T-matrix. The calculation of the ground-state energies is carried out by diagonalizing the Hamiltonian on a Non symmetryzed Hyperspherical Harmonics basis in momentum space. Using only two body interactions a rather strong cutoff dependence appears. However, we are able to reproduce the experimental ground-state energies for selected cutoff values for most of the studied nuclei. The strong cutoff dependence indicates the lack of three-body forces, therefore we extend our Cluster EFT approach by including such many-body forces. Finally, the 9Be photoabsorption cross-section is studied via the Lorentz integral transform method (LIT), focusing on the low-energy resonances coming from the electric dipole transitions. By fine tuning the parameters of the three-body force, we are able to reproduce, up to 4 MeV, the considered experimental resonances. For the description of the spectrum at higher energies the inclusion of the ?? D-wave potential seems to be necessary.
title: MRI features of avascular necrosis of the femoral head: HIPS DON’T LIE
Creators: name: Mahdar, Imane
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: Musculoskeletal joint
subject: MR
subject: Diagnostic procedure
subject: Athletic injuries
subject: Ischaemia / Infarction
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Avascular necrosis of the hip often leads to functional impairment. Early diagnosis is the key to a conservative treatment plan and MRI has proven the most accuracy and sensitivity for early...
Hyperbolic development and inversion of signature
Creators: name: Lyons, Terry
name: Xu, Weijun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: We develop a simple procedure that allows one to explicitly reconstruct any piecewise linear path from its signature. The construction is based on the development of the path onto the hyperbolic space.
description: Revised; 19 pages. We splitted our older article (arXiv:1406.7833) into two independent ones; this is one of them
(401366) Martha (Peggy) Brewster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 4 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S4. Comparison of protein sequence identity between Selaginella species.
title: Patient exposure on stroke emergency - a national approach
Creators: name: Miguel, Filipa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiographers
subject: CT
subject: Fluoroscopy
subject: Dosimetry
subject: Radiation safety
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Stroke is one of the main causes of death across Europe. In Portugal patients are refer for a national emergency network and perform computed tomography (CT) for diagnosis. Some patients also need interventional neuroradiology procedures that can be...
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
Creators: name: Harrison, S. C.
name: Gassmann, R.
name: Masumoto, H.
name: Karpen, G.
name: Maddox, P. S.
name: Warburton, P. E.
name: Musacchio, A.
name: Yanagida, M.
name: Gerlich, D. W.
name: Luger, K.
name: Walczak, C. E.
name: Brown, W.
name: Sullivan, K. F.
name: Stukenberg, P. T.
name: O'Neill, R. J.
name: Meraldi, P.
name: Oegema, K.
name: Cheeseman, I. M.
name: Losada, A.
name: Diekmann, S.
name: Maiato, H.
name: Fitzgerald-Hayes, M.
name: Sullivan, B. A.
name: Desai, A.
name: Mellone, B. G.
name: Swedlow, J. R.
name: Hirota, T.
name: Yen, T. J.
name: Deluca, J. G.
name: Jansen, L. E.T.
name: Gorbsky, G. J.
name: Straight, A. F.
name: Lampson, M. A.
name: Scott, K. C.
name: Cleveland, D. W.
name: Black, B. E.
name: Yoda, K.
name: Erhardt, S.
name: Bloom, K.
name: Fukagawa, T.
name: Choo, K. H.A.
name: Allshire, R. C.
name: McAinsh, A. D.
name: Foltz, D.
name: Westermann, S.
name: Heun, P.
name: Wordeman, L.
name: Lens, S. M.
name: Margolis, R. L.
name: Sunkel, C. E.
name: Kops, G. J.P.L.
name: Brinkley, B. R.
name: Salmon, E. D.
name: Glover, D. M.
name: Earnshaw, W. C.
name: Willard, H. F.
name: Copenhaver, G. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
title: Comprehensive radiological review of granulomatous prostatitis.
Creators: name: Giménez Hernández, Guillermo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system male
subject: MR
subject: Education
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Granulomatous prostatitis is a rare entity but may mimic prostate cancer in multiparametric magnetic resonance imaging of the prostate gland, so we have described the spectrum of clinical and radiological findings of this pathology, and reviewed the...
(401367) [?] Lindsay
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401364) William Douglas Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma
Creators: name: Breen, Matthew
name: Modiano, Jaime F.
name: Rotroff, Daniel
name: Borst, Luke
name: Motsinger-Reif, Alison
name: Lindblad-Toh, Kerstin
name: Thomas, Rachael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Canine hemangiosarcoma is a highly aggressive vascular neoplasm associated with extensive clinical and anatomical heterogeneity and a grave prognosis. Comprehensive molecular characterization of hemangiosarcoma may identify novel therapeutic targets and advanced clinical management strategies, but there are no published reports of tumor-associated genome instability and disrupted gene dosage in this cancer. We performed genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds that are highly predisposed to this disease. The cohort exhibited limited global genomic instability, compared to other canine sarcomas studied to date, and DNA copy number aberrations (CNAs) were predominantly of low amplitude. Recurrent imbalances of several key cancer-associated genes were evident; however the global penetrance of any single CNA was low and no distinct hallmark aberrations were evident. Copy number gains of dog chromosomes 13, 24 and 31, and loss of chromosome 16, were the most recurrent CNAs involving large chromosome regions, but their relative distribution within and between cases suggests they most likely represent passenger aberrations. CNAs involving CDKN2A, VEGFA and the SKI oncogene were identified as potential driver aberrations of hemangiosarcoma development, highlighting potential targets for therapeutic modulation. CNA profiles were broadly conserved between the five breeds, although subregional variation was evident, including a near two-fold lower incidence of VEGFA gain in Golden Retrievers versus other breeds (22% versus 40%). These observations support prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly-distinct subtypes of canine hemangiosarcoma.
title: CT–scan for pulmonary sarcoidosis assessment: typical and atypical findings
Creators: name: Mahdar, Imane
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Lymph nodes
subject: CT
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Computed tomography is the reference for the assessment of both mediastinal lymph nodes and pulmonary findings. The main purpose of this work is to familiarize radiologists with the different manifestations of pulmonary Sarcoidosis and to illustrate...
Additional file 5 of Comparative transcriptome analysis suggests convergent evolution of desiccation tolerance in Selaginella species
Creators: name: Alejo-Jacuinde, Gerardo
name: González-Morales, Sandra Isabel
name: Oropeza-Aburto, Araceli
name: Simpson, June
name: Herrera-Estrella, Luis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Figure S5. Quantitative real-time PCR validation.
A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity
Creators: name: Thomas, R.
name: Brinster, L.
name: Beren, J.
name: Lewis, A. M.
name: Omeir, R.
name: Breen, M.
name: Macauley, J.
name: Teferedegne, B.
name: Foseh, G.
name: Peden, K.
name: Williams, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The molecular mechanisms underlying spontaneous neoplastic transformation in cultured mammalian cells remain poorly understood, confounding recognition of parallels with the biology of naturally occurring cancer. The broad use of tumorigenic canine cell lines as research tools, coupled with the accumulation of cytogenomic data from naturally occurring canine cancers, makes the domestic dog an ideal system in which to investigate these relationships. We developed a canine kidney cell line, CKB1-3T7, which allows prospective examination of the onset of spontaneous immortalization and tumorigenicity. We documented the accumulation of cytogenomic aberrations in CKB1-3T7 over 24months in continuous culture. The majority of aberrations emerged in parallel with key phenotypic changes in cell morphology, growth kinetics, and tumor incidence and latency. Focal deletion of CDKN2A/B emerged first, preceding the onset and progression of tumorigenic potential, and progressed to a homozygous deletion across the cell population during extended culture. Interestingly, CKB1-3T7 demonstrated a tumorigenic phenotype in vivo prior to exhibiting loss of contact inhibition in vitro. We also performed the first genome-wide characterization of the canine tumorigenic cell line MDCK, which also exhibited CDKN2A/B deletion. MDCK and CKB1-3T7 cells shared several additional aberrations that we have reported previously as being highly recurrent in spontaneous canine cancers, many of which, as with CDKN2A/B deletion, are evolutionarily conserved in their human counterparts. The conservation of these molecular events across multiple species, in vitro and in vivo, despite their contrasting karyotypic architecture, is a powerful indicator of a common mechanism underlying emerging neoplastic activity. Through integrated cytogenomic and phenotypic characterization of serial passages of CKB1-3T7 from initiation to development of a tumorigenic phenotype, we present a robust and readily accessible model (to be made available through the American Type Culture Collection) of spontaneous neoplastic transformation that overcomes many of the limitations of earlier studies.Electronic supplementary materialThe online version of this article (doi:10.1007/s10577-015-9474-8) contains supplementary material, which is available to authorized users.
(401365) Ronald Vivian Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
Creators: name: Albertson, D.
name: Knapp, D. W.
name: Breen, M.
name: Jin, J.
name: Raghunath, S.
name: Liu, T.
name: Williams, C.
name: Bergstrom Lucas, A.
name: Motsinger-Reif, A. A.
name: Shapiro, S. G.
name: Cullen, J. M.
name: Schiffman, J. D.
name: Ruvolo, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Urothelial carcinoma (UC), also referred to as transitional cell carcinoma (TCC), is the most common bladder malignancy in both human and canine populations. In human UC, numerous studies have demonstrated the prevalence of chromosomal imbalances. Although the histopathology of the disease is similar in both species, studies evaluating the genomic profile of canine UC are lacking, limiting the discovery of key comparative molecular markers associated with driving UC pathogenesis. In the present study, we evaluated 31 primary canine UC biopsies by oligonucleotide array comparative genomic hybridization (oaCGH). Results highlighted the presence of three highly recurrent numerical aberrations: gain of dog chromosome (CFA) 13 and 36 and loss of CFA 19. Regional gains of CFA 13 and 36 were present in 97% and 84% of cases, respectively, and losses on CFA 19 were present in 77% of cases. Fluorescence in situ hybridization (FISH), using targeted bacterial artificial chromosome (BAC) clones and custom Agilent SureFISH probes, was performed to detect and quantify these regions in paraffin-embedded biopsy sections and urine-derived urothelial cells. The data indicate that these three aberrations are potentially diagnostic of UC. Comparison of our canine oaCGH data with that of 285 human cases identified a series of shared copy number aberrations. Using an informatics approach to interrogate the frequency of copy number aberrations across both species, we identified those that had the highest joint probability of association with UC. The most significant joint region contained the gene PABPC1, which should be considered further for its role in UC progression. In addition, cross-species filtering of genome-wide copy number data highlighted several genes as high-profile candidates for further analysis, including CDKN2A, S100A8/9, and LRP1B. We propose that these common aberrations are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications.
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
Creators: name: Motsinger-Reif, Alison
name: Poorman, Kelsey
name: Breen, Matthew
name: Labelle, Philippe
name: Roy, Siddharth
name: Borst, Luke
name: Moroff, Scott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Melanocytic lesions originating from the oral mucosa or cutaneous epithelium are common in the general dog population, with up to 100,000 diagnoses each year in the USA. Oral melanoma is the most frequent canine neoplasm of the oral cavity, exhibiting a highly aggressive course. Cutaneous melanocytomas occur frequently, but rarely develop into a malignant form. Despite the differential prognosis, it has been assumed that subtypes of melanocytic lesions represent the same disease. To address the relative paucity of information about their genomic status, molecular cytogenetic analysis was performed on the three recognized subtypes of canine melanocytic lesions. Using array comparative genomic hybridization (aCGH) analysis, highly aberrant distinct copy number status across the tumor genome for both of the malignant melanoma subtypes was revealed. The most frequent aberrations included gain of dog chromosome (CFA) 13 and 17 and loss of CFA 22. Melanocytomas possessed fewer genome wide aberrations, yet showed a recurrent gain of CFA 20q15.3–17. A distinctive copy number profile, evident only in oral melanomas, displayed a sigmoidal pattern of copy number loss followed immediately by a gain, around CFA 30q14. Moreover, when assessed by fluorescence in situ hybridization (FISH), copy number aberrations of targeted genes, such as gain of c-MYC (80 % of cases) and loss of CDKN2A (68 % of cases), were observed. This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways.