cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review
Creators: name: Moustaqim-Barrette, Amina
name: Dhillon, Damon
name: Ng, Justin
name: Sundvick, Kristen
name: Ali, Farihah
name: Elton-Marshall, Tara
name: Leece, Pamela
name: Rittenbach, Katherine
name: Ferguson, Max
name: Buxton, Jane A.
Publisher: name: BioMed Central
Year: 2021

description: Background: Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged as a key intervention in reducing opioid overdose deaths. These programs aim to train individuals at risk of witnessing or experiencing an opioid overdose to recognize an opioid overdose and respond with naloxone. Naloxone effectively reverses opioid overdoses on a physiological level; however, there are outstanding questions on community THN program effectiveness (adverse events, dosing requirements, dose-response between routes of administration) and implementation (accessibility, availability, and affordability). The objective of this scoping review is to identify existing systematic reviews and best practice guidelines relevant to clinical and operational guidance on the distribution of THN. Methods: Using the Arksey & O’Malley framework for scoping reviews, we searched both academic literature and grey literature databases using keywords (Naloxone) AND (Overdose) AND (Guideline OR Review OR Recommendation OR Toolkit). Only documents which had a structured review of evidence and/or provided summaries or recommendations based on evidence were included (systematic reviews, meta-analyses, scoping reviews, short-cut or rapid reviews, practice/clinical guidelines, and reports). Data were extracted from selected evidence in two key areas: (1) study identifiers; and (2) methodological characteristics. Results: A total of 47 articles met inclusion criteria: 20 systematic reviews; 10 grey literature articles; 8 short-cut or rapid reviews; 4 scoping reviews; and 5 other review types (e.g. mapping review and comprehensive reviews). The most common subject themes were: naloxone effectiveness, safety, provision feasibility/acceptability of naloxone distribution, dosing and routes of administration, overdose response after naloxone administration, cost-effectiveness, naloxone training and education, and recommendations for policy, practice and gaps in knowledge. Conclusions: Several recent systematic reviews address the effectiveness of take-home naloxone programs, naloxone dosing/route of administration, and naloxone provision models. Gaps remain in the evidence around evaluating cost-effectiveness, training parameters and strategies, and adverse events following naloxone administration. As THN programs continue to expand in response to opioid overdose deaths, this review will contribute to understanding the evidence base for policy and THN program development and expansion.
Additional file 1 of Predictors of independence in older people: A longitudinal, population-based study using the CARE75 + cohort
Creators: name: Taylor, Emily
name: Goodwin, Victoria A
name: Clegg, Andrew
name: Brown, Lesley
name: Frost, Julia
name: Ball, Susan
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Supplementary Material 1
Additional file 1 of Functional connectivity between the visual and salience networks and autistic social features at school-age
Creators: name: Girault, Jessica B.
name: Nishino, Tomoyuki
name: Talović, Muhamed
name: Nebel, Mary Beth
name: Reynolds, Margaret
name: Burrows, Catherine A.
name: Elison, Jed T.
name: Lee, Chimei M.
name: Snyder, Abraham Z.
name: Shen, Mark D.
name: Shen, Audrey M.
name: Botteron, Kelly N.
name: Estes, Annette M.
name: Dager, Stephen R.
name: Gerig, Guido
name: Hazlett, Heather C.
name: Marrus, Natasha
name: McKinstry, Robert C.
name: Pandey, Juhi
name: Schultz, Robert T.
name: John, Tanya St
name: Styner, Martin A.
name: Zwaigenbaum, Lonnie
name: Todorov, Alexandre A.
name: Piven, Joseph
name: Pruett, John R.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Supplementary Material 1
Education and training in environmental health services evaluation
Creators: name: Jordan, Helen
name: Dunn, Louise
name: Verrinder, Glenda
Publisher: name: Swinburne
Year: 2024

description: A multi-functional educational and training module in Environmental Health Services Evaluation has recently been developed to build environmental health management evaluation capacity in Australia. Three institutions involved in the delivery of environmental health educational programs worked together with other key stakeholders to produce a module in Environmental Health Services Evaluation. A consultative approach was adopted to identify key content areas, and provide expert feedback on the content and format of delivery. The product, 12 connected modular sessions in Environmental Health Services Evaluation, is available for use, in a range of delivery-modes, by institutions involved in the education of environmental health practitioners (EHPs). This paper reports on the development of this module and its potential for improving evaluation and hence practice and outcomes in environmental health.
Conference programme
Creators: name: School Of Population Health
Publisher: name: Royal College of Surgeons in Ireland
Year: 2025
Subjects: classificationCode: 420302
subject: Digital health
classificationCode: 420311
subject: Health systems
classificationCode: 4206
subject: Public health
classificationCode: 350718
subject: Strategy
classificationCode: 4602
subject: Artificial intelligence
classificationCode: 440302
subject: Fertility
classificationCode: 3210
subject: Nutrition and dietetics
classificationCode: 320208
subject: Endocrinology
classificationCode: 520404
subject: Memory and attention
classificationCode: 390110
subject: Medicine, nursing and health curriculum and pedagogy
classificationCode: 320216
subject: Orthopaedics
classificationCode: 320226
subject: Surgery
classificationCode: 321502
subject: Obstetrics and gynaecology

description: Programme of 'Better health outcomes from digital health?’ National Healthcare Outcomes Conference, RCSI University of Medicine and Health Sciences, 8 April 2025.
Predictive Modeling of a Simple Field Matrix Diffusion Experiment Addressing Radionuclide Transport in Fractured Rock. Is It So Straightforward?
Creators: name: Soler, J. M.
name: Neretnieks, I.
name: Moreno, L.
name: Liu, L.
name: Meng, S.
name: Svensson, U.
name: Iraola, A.
name: Ebrahimi, H.
name: Trinchero, P.
name: Molinero, J.
name: Vidstrand, P.
name: Deissmann, G.
name: Říha, J.
name: Hokr, M.
name: Vetešník, A.
name: Vopálka, D.
name: Gvoždík, L.
name: Polák, M.
name: Trpkošová, D.
name: Havlová, V.
name: Park, D.-K.
name: Ji, S.-H.
name: Tachi, Y.
name: Ito, T.
name: Gylling, B.
name: Lanyon, G. W.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The SKB GroundWater Flow and Transport of Solutes Task Force is an international forum in the area of conceptual and numerical modeling of groundwater flow and solute transport in fractured rocks relevant for the deep geological disposal of radioactive waste. Two in situ matrix diffusion experiments in crystalline rock (gneiss) were performed at POSIVA’s ONKALO underground facility in Finland. Synthetic groundwater containing several conservative and sorbing radiotracers was injected at one end of a borehole interval and flowed along a thin annulus toward the opposite end. Several teams performed predictive modeling of the tracer breakthrough curves using “conventional” modeling approaches (constant diffusion and sorption in the rock, no or minimum rock heterogeneity). Supporting information, derived from small-scale laboratory experiments, was provided. The teams were free to implement different concepts, use different codes, and apply the transport and retention parameters that they considered to be most suited (i.e., not a benchmark exercise). The main goal was the comparison of the different sets of results and the analysis of the possible differences for this relatively simple experimental setup with a well-defined geometry. Even though the experiment was designed to study matrix diffusion, the calculated peaks of the breakthrough curves were very sensitive to the assumed magnitude of dispersion in the borehole annulus. However, given the very different timescales for advection and matrix diffusion, the tails of the curves provided information concerning diffusion and retention in the rock matrix regardless of the magnitude of dispersion. In addition, although the task was designed to be a blind modeling exercise, the model results have also been compared to the measured experimental breakthroughs. Experimental results tend to show relatively small activities, wide breakthroughs, and early first arrivals, which are somewhat similar to model results using large dispersivity values.
Additional file 1 of Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems
Creators: name: Zhao, Mingming
name: Kim, Jeongwon
name: Jiao, Jiayan
name: Lim, Yelin
name: Shi, Xianai
name: Guo, Shaobin
name: Kim, Jongmin
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: Supplementary Material 1: Additional file 1 Description of data: Detailed experimental procedures for design algorithm, supplementary figures for secondary structure simulations of SWTs, characterizations of the SWTs at different concentrations, crosstalk simulations between SWTs, orthogonality assessments of SWTs, supplementary tables for construct sequences used in this study.
Digital health: what is it & what can it do for outcomes?
Creators: name: Argent, Rob
Publisher: name: Royal College of Surgeons in Ireland
Year: 2025
Subjects: classificationCode: 420302
subject: Digital health
classificationCode: 420311
subject: Health systems
classificationCode: 4206
subject: Public health
classificationCode: 350718
subject: Strategy

description: A paper presented at the 'Better health outcomes from digital health?’ National Healthcare Outcomes Conference, RCSI University of Medicine and Health Sciences, 8 April 2025.
A phase II multi-arm study of magrolimab combinations in patients with relapsed/refractory multiple myeloma
Creators: name: Paul, Barry
name: Liedtke, Michaela
name: Khouri, Jack
name: Rifkin, Robert
name: Gandhi, Mitul D
name: Kin, Andrew
name: Levy, Moshe Y
name: Silbermann, Rebecca
name: Cottini, Francesca
name: Sborov, Douglas W
name: Sandhu, Irwindeep
name: Villarreal, Lyssa
name: Murphy, Michael
name: Gu, Lin
name: Chen, Ann
name: Rajakumaraswamy, Nishanthan
name: Usmani, Saad Z
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Magrolimab is a monoclonal antibody that blocks CD47, a ‘do not eat me’ signal overexpressed on tumor cells. CD47 is overexpressed in multiple myeloma (MM), which contributes to its pathogenesis. Preclinical studies have shown that CD47 blockade induces macrophage activation, resulting in elimination of myeloma cells, and that there is synergy between magrolimab and certain anticancer therapies. These findings suggest that magrolimab-based combinations may have a therapeutic benefit in MM. This phase II study investigates magrolimab in combination with commonly used myeloma therapies in patients with relapsed/refractory MM and includes a safety run-in phase followed by a dose-expansion phase. Primary end points include the incidence of dose-limiting toxicities and adverse events (safety run-in) and the objective response rate (dose expansion). Magrolimab is a therapy that blocks a ‘do not eat me’ signal overexpressed by certain cancers, including multiple myeloma (MM) cells. Studies have shown that blocking this signal leads to destruction of myeloma cellsand that this cancer-killing effect may be increased by combining magrolimab with certain additional anticancer therapies. These findings suggest that magrolimab-based combinations may have a therapeutic benefit in MM. This study is investigating magrolimab in combination with commonly used myeloma therapies in patients with MM who have persistent disease despite prior treatment. Goals of the trial include assessing safety and response to treatment. Clinical Trial Registration:NCT04892446 (ClinicalTrials.gov) A PDF version of this infographic is available as supplemental material. This phase II study investigates safety and treatment response to #magrolimab, an antibody that enhances phagocytosis of cancer cells, combined with commonly used therapies in patients with #multiplemyeloma.
title: Social impact of the COVID-19 pandemic in Germany and possible consequences for environmental policy
title: Social impact of the COVID-19 pandemic in Germany and possible consequences for environmental policy
titleType: AlternativeTitle
Creators: name: Klatt, Anne
name: Schwirn, Kathrin
name: Spengler, Laura
name: Löwe, Christian
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Pandemie
subject: Sozialverträglichkeitsprüfung
subject: Corona
subject: Covid-19 crisis
subject: pandemic
subject: social impact assessment
subject: Sustainability | Strategies | International matters

description: The COVID-19 pandemic has suddenly and fiercely changed social life around the world. Besides the diverse, in part drastic negative consequences, the crisis has also produced situations and pictures that seem utopian in â€Ìnormalâ€Ì times. Some of these impacts will soon fade away, others are very likely to continue in the longer term. The pandemic has thus changed the social context for environmental action. Against this background, this discussion paper deals with the following two questions: Which social impacts of the pandemic are relevant for environmental policy? And how should environmental policy react to these changes? Quelle: www.umweltbundesamt.de
description: The COVID-19 pandemic has suddenly and fiercely changed social life around the world. Besides the diverse, in part drastic negative consequences, the crisis has also produced situations and pictures that seem utopian in “normal” times. Some of these impacts will soon fade away, others are very likely to continue in the longer term. The pandemic has thus changed the social context for environmental action. Against this background, this discussion paper deals with the following two questions: Which social impacts of the pandemic are relevant for environmental policy? And how should environmental policy react to these changes?
“The Problem Is that We Hear a Bit of Everything…”: A Qualitative Systematic Review of Factors Associated with Alcohol Use, Reduction, and Abstinence in Pregnancy
Creators: name: Lyall, Vivian
name: Wolfson, Lindsay
name: Reid, Natasha
name: Poole, Nancy
name: Moritz, Karen M.
name: Egert, Sonya
name: Browne, Annette J.
name: Askew, Deborah A.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Understanding the factors that contribute to women’s alcohol use in pregnancy is critical to supporting women’s health and wellness and preventing Fetal Alcohol Spectrum Disorder. A systematic review of qualitative studies involving pregnant and recently postpartum women was undertaken to understand the barriers and facilitators that influence alcohol use in pregnancy (PROSPERO: CRD42018098831). Twenty-seven (n = 27) articles were identified through EMBASE, CINAHL, PsycINFO, PubMed and Web of Science. The included articles were thematically analyzed using NVivo12. The analysis was informed by Canada’s Action Framework for Building an Inclusive Health System to articulate the ways in which stigma and related barriers are enacted at the individual, interpersonal, institutional and population levels. Five themes impacting women’s alcohol use, abstention and reduction were identified: (1) social relationships and norms; (2) stigma; (3) trauma and other stressors; (4) alcohol information and messaging; and (5) access to trusted equitable care and essential resources. The impact of structural and systemic factors on prenatal alcohol use was largely absent in the included studies, instead focusing on individual choice. This silence risks perpetuating stigma and highlights the criticality of addressing intersecting structural and systemic factors in supporting maternal and fetal health.
Risk, “Radiophobia,” and Social Learning: Applying Lessons from the Literature
Creators: name: Shasko, Larissa
name: Neetz, Michaela
name: Hurlbert, Margot
name: Rayner, Jeremy
name: Landrie-Parker, Dazawray
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Social learning aims to produce a change in both understanding and behavior on the part of individuals that diffuses to wider social units and communities of practice. This paper asks: What lessons from the social learning literature can be applied to research and public engagement with respect to radiation exposure risk? Five key lessons were assembled, and recent survey results were used to demonstrate how these lessons can be applied to outline a risk communication strategy that includes, but is not limited to, well-designed engagement. The marked divergence between public and “expert” opinion on radiation exposure risk remains at the heart of current debates over the role of nuclear energy in tackling climate change. Earlier literature tended to be dismissive of the risk gap, siding with the experts and branding the public “radiophobic.” We show how applying the findings of the literature review to the design and analysis of the survey can overcome shortcomings of past approaches and build on strengths. This paper seeks to demonstrate the importance and interrelated nature of mixed-methods studies where quantitative and qualitative analysis is combined. This includes avoiding overly binary approaches of study and finding ways to open up conversations and exchanges. This exploration of social learning and public engagement highlights the potential barriers nuclear energy faces in contributing to the future energy mix and challenges current practices to be more perceptive to the spectrum of public positions to radiation exposure risk.
Laser Interference Lithography—A Method for the Fabrication of Controlled Periodic Structures
Creators: name: Liu, Ri
name: Liang, Cao
name: Lu, Wang
name: Sadeg, Saeed
name: Zuobin, Wang
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Laser Interference Lithography
subject: periodic structures
subject: Nanotechnology
subject: FOS: Nanotechnology
subject: nano materials

description: A microstructure determines macro functionality. A controlled periodic structure gives the surface specific functions such as controlled structural color, wettability, anti-icing/frosting, friction reduction, and hardness enhancement. Currently, there are a variety of controllable periodic structures that can be produced. Laser interference lithography (LIL) is a technique that allows for the simple, flexible, and rapid fabrication of high-resolution periodic structures over large areas without the use of masks. Different interference conditions can produce a wide range of light fields. When an LIL system is used to expose the substrate, a variety of periodic textured structures, such as periodic nanoparticles, dot arrays, hole arrays, and stripes, can be produced. The LIL technique can be used not only on flat substrates, but also on curved or partially curved substrates, taking advantage of the large depth of focus. This paper reviews the principles of LIL and discusses how the parameters, such as spatial angle, angle of incidence, wavelength, and polarization state, affect the interference light field. Applications of LIL for functional surface fabrication, such as anti-reflection, controlled structural color, surface-enhanced Raman scattering (SERS), friction reduction, superhydrophobicity, and biocellular modulation, are also presented. Finally, we present some of the challenges and problems in LIL and its applications.
Additional file 1 of Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention
Creators: name: Choo, Eun Ho
name: Moon, Donggyu
name: Choi, Ik Jun
name: Lim, Sungmin
name: Lee, Jungkuk
name: Kang, Dongwoo
name: Hwang, Byung-Hee
name: Kim, Chan Joon
name: Lee, Jong-Min
name: Yoo, Ki-Dong
name: Jeon, Doo Soo
name: Chang, Kiyuk
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
Real-world adjuvant chemotherapy patterns and outcomes among elderly patients with resected early non-small-cell lung cancer in the USA
Creators: name: Lee, Jay M
name: Wang, Rongrong
name: Johnson, Ann
name: Ogale, Sarika
name: Kent, Matthew
name: Lee, Janet S
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Developmental Biology
Cancer
Science Policy

description: Background: This study investigated real-world treatment patterns and overall survival (OS) in early non-small-cell lung cancer patients and the association between OS and time-to-adjuvant-treatment. Materials & methods: This retrospective study using Surveillance, Epidemiology and End Results data linked with Medicare claims included resected early non-small-cell lung cancer patients between 2010 and 2015. Unadjusted OS analyses used Kaplan–Meier curves; adjusted OS analyses used extended Cox proportional hazards models. Results: Only 54–71% of stage II–IIIA patients received any adjuvant treatment. Adjusted risk of death was higher when starting treatment outside 6–8weeks after surgery (p<0.05). Conclusion: Improved systemic therapy in the adjuvant chemotherapy setting is needed. Lung cancer is one of the deadliest cancers in the USA. Most lung cancers are a type called non-small-cell lung cancer (NSCLC). Patients with NSCLC that has not spread to other parts of the body generally have surgery and may receive treatment before surgery, after surgery or both to help fight the cancer. It is not clear how often people receive treatment before or after surgery. It is important to know how patients are being treated because it helps clinicians decide how to use the new treatments that are becoming available. This study used a large database of more than 7000 people aged 65years and older with lung cancer in the USA to understand how they are treated. More than a third of patients had stage IA NSCLC (39%), followed by stage IB (24%), stage II (20%), stage IIIA (15%) and stage IIIB (2%). Most people had surgery (64%) and some received another treatment after surgery (27%). That treatment was most often about 2months of chemotherapy, on average. The study also tried to understand how the timing of treatment may have been important for their survival. People who received treatment after surgery lived the longest if they received that treatment about 6–8weeks after the surgery. Overall, the study showed that a substantial proportion of people do not receive treatment for their NSCLC after surgery, even though treatment after surgery is recommended by medical guidelines. There is a need for more effective treatments for these patients, and when those treatments are given may be important for their survival. Only 54–71% of US Medicare patients with stage II-IIIA NSCLC receive any adjuvant treatment. Chances of survival are best when treatment is given 6–8 weeks after surgery. Improved systemic therapy is needed in the adjuvant chemotherapy setting for people with early NSCLC.
Additional file 1 of Quantitative modeling of lenticulostriate arteries on 7-T TOF-MRA for cerebral small vessel disease
Creators: name: Li, Zhixin
name: Sun, Dongbiao
name: Ling, Chen
name: Bai, Li
name: Zhang, Jinyuan
name: Wu, Yue
name: Yuan, Yun
name: Wang, Zhaoxia
name: Wang, Zhe
name: Zhuo, Yan
name: Xue, Rong
name: Zhang, Zihao
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Supplementary Table S1. Hyper-parameter setups for the candidate networks used in the study. Supplementary Figure S1. Trends of the accuracy and the loss value in SP-CNN training. Supplementary Figure S2. The ROC curves showed the sensitivity and specificity of detecting CADASIL according to different diameter scales. Supplementary Figure S3. Segmentation results of SP-CNN by using different interpolated voxel sizes. The red circle indicates the blood vessels that were missed when the voxel size is reduced to isotropic 0.20 mm.
“Better health outcomes”
Creators: name: Tierney, Derek
Publisher: name: Royal College of Surgeons in Ireland
Year: 2025
Subjects: classificationCode: 420302
subject: Digital health
classificationCode: 420311
subject: Health systems
classificationCode: 4206
subject: Public health
classificationCode: 350718
subject: Strategy

description: A paper presented at the 'Better health outcomes from digital health?’ National Healthcare Outcomes Conference, RCSI University of Medicine and Health Sciences, 8 April 2025.
Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques
Creators: name: Ren, Jinhong
name: Mistry, Tina L
name: Su, Pin-Chih
name: Mehboob, Shahila
name: Demissie, Robel
name: Fung, Leslie Wo-Mei
name: Ghosh, Arun K
name: Johnson, Michael
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences

description: We have previously reported benzimidazole-based compounds to be potent inhibitors of FabI for Francisella tularensis (FtFabI), making them promising antimicrobial hits. Optically active enantiomers exhibit markedly differing affinities toward FtFabI. The IC50 of benzimidazole (-)-1 is ∼100× lower than the (+)-enantiomer, with similar results for the 2 enantiomers. Determining the absolute configuration for these optical compounds and elucidating their binding modes is important for further design. Electronic circular dichroism (ECD) quantum calculations have become important in determining absolute configurations of optical compounds. We determined the absolute configuration of (-)/(+)-1 and (-)/(+)-2 by comparing experimental spectra and theoretical density functional theory (DFT) simulations of ECD spectra at the B3LYP/6-311+G(2d, p) level using Gaussian09. Comparison of experimental and calculated ECD spectra indicates that the S configuration corresponds to the (-)-rotation for both compounds 1 and 2, while the R configuration corresponds to the (+)-rotation. Further, molecular dynamics simulations and MM-GBSA binding energy calculations for these two pairs of enantiomers with FtFabI show much tighter binding MM-GBSA free energies for S-1 and S-2 than for their enantiomers, R-1 and R-2, consistent with the S configuration being the more active one, and with the ECD determination of the S configuration corresponding to (-) and the R configuration corresponding to (+). Thus, our computational studies allow us to assign (-) to (S)- and (+) to (R)- for compounds 1 and 2, and to further evaluate structural changes to improve efficacy.
Additional file 1 of Racial issues in psychiatry: a thematic analysis of an initial health equity educational activity for medical students
Creators: name: Pickerl, Paige
name: Sorrell, Tanya
name: Blue, Mennefer
name: Patterson, Kamaria
name: Sheth, Neeral
name: Givens, Sahara
Publisher: name: figshare
Year: 2025
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 1
Additional file 2 of Racial issues in psychiatry: a thematic analysis of an initial health equity educational activity for medical students
Creators: name: Pickerl, Paige
name: Sorrell, Tanya
name: Blue, Mennefer
name: Patterson, Kamaria
name: Sheth, Neeral
name: Givens, Sahara
Publisher: name: figshare
Year: 2025
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 2
Additional file 1 of High anaemia and iron deficiency prevalence among pregnant women living in low groundwater iron areas of Bangladesh
Creators: name: Hasan, Mohammed Imrul
name: Ahmed, Shamim
name: McLean, Alistair R. D.
name: M Quaiyum Rahman, A.
name: Bhuiyan, Mohammad Saiful Alam
name: Tipu, S. M. Mulk Uddin
name: Braat, Sabine
name: Arifeen, Shams El
name: Hamadani, Jena D.
name: Pasricha, Sant-Rayn
name: Davidson, Eliza M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1.
Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation.
Creators: name: McGillick, Erin V
name: Orgeig, Sandra
name: Allison, Beth J
name: Brain, Kirsty L
name: Niu, Youguo
name: Itani, Nozomi
name: Skeffington, Katie L
name: Kane, Andrew D
name: Herrera, Emilio A
name: Morrison, Janna L
name: Giussani, Dino
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022

description: BACKGROUND: In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnatal life and adulthood. However, the outcomes and biological mechanisms of antioxidant action in the fetal lung are unknown. METHODS: We investigated the effect of maternal daily vitamin C treatment (200 mg/kg, intravenously) for a month in late gestation (105-138 days gestation, term ~145 days) on molecular regulation of fetal lung maturation in sheep. Expression of genes and proteins regulating lung development was quantified in fetal lung tissue. The number of surfactant-producing cells was determined by immunohistochemistry. RESULTS: Maternal vitamin C treatment increased fetal lung gene expression of the antioxidant enzyme SOD-1, hypoxia signaling genes (HIF-2α, HIF-3α, ADM, and EGLN-3), genes regulating sodium movement (SCNN1-A, SCNN1-B, ATP1-A1, and ATP1-B1), surfactant maturation (SFTP-B and ABCA3), and airway remodeling (ELN). There was no effect of maternal vitamin C treatment on the expression of protein markers evaluated or on the number of surfactant protein-producing cells in fetal lung tissue. CONCLUSIONS: Maternal vitamin C treatment in the last third of pregnancy in sheep acts at the molecular level to increase the expression of genes that are important for fetal lung maturation in a healthy pregnancy. IMPACT: Maternal daily vitamin C treatment for a month in late gestation in sheep increases the expression of gene-regulating pathways that are essential for normal fetal lung development. Following late gestation vitamin C exposure in a healthy pregnancy, an increase in lung gene but not protein expression may act as a mechanism to aid in the preparation for exposure to the air-breathing environment after birth. In the future, the availability/development of compounds with greater antioxidant properties than vitamin C or more specific targets at the site of oxidative stress in vivo may translate clinically to improve respiratory outcomes in complicated pregnancies at birth.
description: National Health and Medical Research Council (NHMRC) of Australia
Are Climate Factors Driving the Contemporary Wildfire Occurrence in China?
Creators: name: Lan, Zige
name: Su, Zhangwen
name: Guo, Meng
name: C. Alvarado, Ernesto
name: Guo, Futao
name: Hu, Haiqing
name: Wang, Guangyu
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Understanding the drivers of wildfire occurrence is of great value for fire prevention and management, but due to the variation in research methods, data sources, and data resolution of those studies, it is challenging to conduct a large-scale comprehensive comparative qualitative analysis on the topic. China has diverse vegetation types and topography, and has undergone rapid economic and social development, but experiences a high frequency of wildfires, making it one of the ideal locations for wildfire research. We applied the Random Forests modelling approach to explore the main types of wildfire drivers (climate factors, landscape factors and human factors) in three high wildfire density regions (Northeast (NE), Southwest (SW), and Southeast (SE)) of China. The results indicate that climate factors were the main driver of wildfire occurrence in the three regions. Precipitation and temperature significantly impacted the fire occurrence in the three regions due to the direct influence on the moisture content of forest fuel. However, wind speed had important influence on fire occurrence in the SE and SW. The explanation power of the landscape and human factors varied significantly between regions. Human factors explained 40% of the fire occurrence in the SE but only explained less than 10% of the fire occurrence in the NE and SW. The density of roads was identified as the most important human factor driving fires in all three regions, but railway density had more explanation power on fire occurrence in the SE than in the other regions. The landscape factors showed nearly no influence on fire occurrence in the NE but explained 46.4% and 20.6% in the SE and SW regions, respectively. Amongst landscape factors, elevation had the highest average explanation power on fire occurrence in the three regions, particularly in the SW. In conclusion, this study provides useful insights into targeted fire prediction and prevention, which should be more precise and effective under climate change and socio-economic development.
The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus
Creators: name: Dean, Matthew
name: Austin, Julia
name: Jinhong, Ren
name: Johnson, Michael
name: Lantvit, Daniel D
name: Burdette, Joanna
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Apigenin is a flavonoid with well-documented anti-cancer properties; however, its mechanisms of action are still unclear. We previously identified apigenin as a potential phytoprogestin, a natural product with a chemical scaffold that interacts with the progesterone receptor (PR). Our objective was to characterize the ability of apigenin to interact with PR through molecular docking studies, in vitro activity assays, and the ability of apigenin to elicit progestin-like effects in vivo. Molecular docking confirmed that apigenin could interact with PR, though with lower affinity than progesterone due to fewer van der Waals interactions. In Ishikawa cells stably expressing PR-B, apigenin significantly increased progesterone response element/luciferase (PRE/Luc) activity at 5 and 10 μM, but not in the parental Ishikawa cells that lack PR expression. In the presence of 100 nM of progesterone, 10 μM apigenin reduced PRE/Luc activity, indicative of mixed agonist activity. Apigenin also triggered degradation of PR in Ishikawa PR-B cells as measured by western blot. Apigenin reduced proliferation of Ishikawa cells, but through a PR-independent mechanism. In contrast, apigenin and progesterone both stimulated proliferation of T47D cells, an effect blocked by RU486. Apigenin activated other nuclear receptors evidenced by increased luciferase activity in MDA-MB-231 cells, which are PR negative. In vivo, apigenin blocked the genistein-stimulated increase in uterine epithelial cell height; stimulated endometrial expression of Hand2, a transcription factor stimulated by PR, and significantly reduced genistein-induced proliferation. In summary, apigenin is a phytoprogestin, with mixed agonist activity that demonstrates activity in vivo by hindering estrogen receptor-mediated uterine proliferation.
Additional file 1 of Pain and depressive symptoms among adolescents: prevalence and associations with achievement pressure and coping in the Norwegian Ungdata study
Creators: name: Jahre, Henriette
name: Grotle, Margreth
name: Smedbråten, Kaja
name: Richardsen, Kåre Rønn
name: Øiestad, Britt Elin
Publisher: name: figshare
Year: 2024
Subjects: Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Marine Biology
Science Policy
Mental Health
Computational Biology

description: Additional file 1. Overview of missing variables.
Additional file 1 of Cerium-doped calcium carbonate microparticles combined with low-intensity ultrasound for efficient sonodynamic therapy in body sculpting
Creators: name: Lin, Jhih-Ni
name: Chi, Chih-Ying
name: Lin, Yu-Ying
name: Kuan, Che-Yung
name: Chang, Chia-Tien
name: Lin, Li-Ze
name: Yang, I-Hsuan
name: Lin, Feng-Huei
Publisher: name: figshare
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Computational Biology

description: Supplementary Material 1
Digital for care 2030 empowering people: the future of digital transformation in the health service
Creators: name: Greene, Richard
Publisher: name: Royal College of Surgeons in Ireland
Year: 2025
Subjects: classificationCode: 420302
subject: Digital health
classificationCode: 420311
subject: Health systems
classificationCode: 4206
subject: Public health
classificationCode: 350718
subject: Strategy

description: A paper presented at the 'Better health outcomes from digital health?’ National Healthcare Outcomes Conference, RCSI University of Medicine and Health Sciences, 8 April 2025.
title: Stockage d'énergie par pompage thermique low-tech à faible empreinte carbone en milieu minier : revue critique de la faisabilite du stockage en lit garni par pulvérisation d'huile thermique sur des roches locales
Creators: name: Durand, Sullivan
name: Haillot, Didier
name: Rousse, Daniel
Publisher: name: Société Française de Thermique
Year: 2024
Subjects: Pompage thermique
Stockage d'énergie
Multi
energétique
Lit garni
Pulvérisation d'huile thermique

description: Le stockage d'énergie par pompage thermique multi-énergétique se positionne comme une solution privilégiée pour le stockage énergétique en milieu minier. L'intégration du stockage en lit garni par pulvérisation d'huile thermique sur des roches extraites à proximité permettrait de réduire la période de retour sur investissement et l'impact environnemental du système. Cette revue examine la recherche actuelle sur ces systèmes et propose une analyse critique de la faisabilité de l'intégration du stockage en lit garni par pulvérisation d'huile thermique sur des roches extraites localement.
Additional file 2 of Pain and depressive symptoms among adolescents: prevalence and associations with achievement pressure and coping in the Norwegian Ungdata study
Creators: name: Jahre, Henriette
name: Grotle, Margreth
name: Smedbråten, Kaja
name: Richardsen, Kåre Rønn
name: Øiestad, Britt Elin
Publisher: name: figshare
Year: 2024
Subjects: Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Marine Biology
Science Policy
Mental Health
Computational Biology

description: Additional file 2. Scores from the subscales of the pressure scale.
Additional file 3 of Racial issues in psychiatry: a thematic analysis of an initial health equity educational activity for medical students
Creators: name: Pickerl, Paige
name: Sorrell, Tanya
name: Blue, Mennefer
name: Patterson, Kamaria
name: Sheth, Neeral
name: Givens, Sahara
Publisher: name: figshare
Year: 2025
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 3
Additional file 1 of CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants
Creators: name: Oksza-Orzechowski, Kazimierz
name: Quinten, Edwin
name: Shafighi, Shadi
name: Kiełbasa, Szymon M.
name: van Kessel, Hugo W.
name: de Groen, Ruben A. L.
name: Vermaat, Joost S. P.
name: Sepúlveda Yáñez, Julieta H.
name: Navarrete, Marcelo A.
name: Veelken, Hendrik
name: van Bergen, Cornelis A. M.
name: Szczurek, Ewa
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figures S1-S14.
Symposium of action learning: introduction
Creators: name: Ramos, Jose M.
Publisher: name: Swinburne
Year: 2024

description: Action learning / research is a broad field of research with deep roots in the 20th century. Unlike futures studies, which is more content oriented (i.e., the futures of health, peace futures, global futures), action learning / research is process and methodology oriented – addressing the manner in which research is done, rather than what is researched. At its core it is collaborative learning for social change. This is particularly important because, in this age of heterogenous changes and multi-fold social challenges, we need to be able to bridge learning about our futures with action and innovation in the present, in a way that is effective and accessible for lay communities and organisations, not just experts. [Introduction]
Burden of disease due to ambient particulate matter in Germany - explaining the differences in the available estimates
Creators: name: Kienzler, Sarah
name: Plaß, Dietrich
name: Schuster, Christian
name: Tobollik, Myriam
name: Wintermeyer, Dirk
Publisher: name: My University
Year: 2022
Subjects: Luftverunreinigung
Schwebstaub
Umweltbedingte Krankheitslast [EBD]
Bundesrepublik Deutschland

description: Ambient particulate matter (PM2.5) pollution is an important threat to human health. The aim of this study is to estimate the environmental burden of disease (EBD) for the German population associated with PM2.5 exposure in Germany for the years 2010 until 2018. The EBD method was used to quantify relevant indicators, e.g., disability-adjusted life years (DALYs), and the life table approach was used to estimate the reduction in life expectancy caused by long-term PM2.5 exposure. The impact of varying assumptions and input data was assessed. From 2010 to 2018 in Germany, the annual population-weighted PM2.5 concentration declined from 13.7 to 10.8 (micro)g/m3. The estimates of annual PM2.5-attributable DALYs for all disease outcomes showed a downward trend. In 2018, the highest EBD was estimated for ischemic heart disease (101.776; 95% uncertainty interval (UI) 62,713-145,644), followed by lung cancer (60,843; 95% UI 43,380-79,379). The estimates for Germany differ from those provided by other institutions. This is mainly related to considerable differences in the input data, the use of a specific German national life expectancy and the selected relative risks. A transparent description of input data, computational steps, and assumptions is essential to explain differing results of EBD studies to improve methodological credibility and trust in the results. Furthermore, the different calculated indicators should be explained and interpreted with caution. 2022 by the authors
Additional file 5 of CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants
Creators: name: Oksza-Orzechowski, Kazimierz
name: Quinten, Edwin
name: Shafighi, Shadi
name: Kiełbasa, Szymon M.
name: van Kessel, Hugo W.
name: de Groen, Ruben A. L.
name: Vermaat, Joost S. P.
name: Sepúlveda Yáñez, Julieta H.
name: Navarrete, Marcelo A.
name: Veelken, Hendrik
name: van Bergen, Cornelis A. M.
name: Szczurek, Ewa
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Review history.
Additional file 1 of A case study of the development of a valid and pragmatic implementation science measure: the Barriers and Facilitators in Implementation of Task-Sharing Mental Health interventions (BeFITS-MH) measure
Creators: name: Yang, Lawrence H.
name: Bass, Judy K.
name: Le, PhuongThao D
name: Singh, Ritika
name: Gurung, Dristy
name: Velasco, Paola R.
name: Grivel, Margaux M.
name: Susser, Ezra
name: Cleland, Charles M.
name: Alvarado, Rubén
name: Kohrt, Brandon A.
name: Bhana, Arvin
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Supplementary Material 1. Full BeFITS-MH measure - Client and Provider Versions.
Discovery of Small Molecule Inhibitors of Adenovirus by Disrupting E3-19K/HLA-A2 Interactions
Creators: name: Ren, Jinhong
name: Dsouza, Nikita R
name: Deng, Hui
name: Lee, Hyun
name: Bouvier, Marlene
name: Johnson, Michael
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences

description: The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an important role in Ad infections, which is the causative agent of a series of gastrointestinal, respiratory and ocular diseases. The objective of this research is to evaluate the essential interactions between E3-19K and HLA-A2 using the X-ray crystal structure of the E3-19K/HLA-A2 complex, and to identify small molecules that could potentially disrupt their binding. Computational methods, including molecular dynamic simulations, MM/GBSA calculations, and computational solvent mapping, were implemented to determine potential binding site(s) for small molecules. The previous experimentally determined hot spot residues, Q54 and E177 in HLA-A2, were also predicted to be the dominant residues for binding to E3-19K by our theoretical calculations. Several other residues were also found to play pivotal roles for the binding of E3-19K with HLA-A2. Residues adjacent to E177, including Q54 and several other residues theoretically predicted to be crucial in HLA-A2 were selected as a potential binding pocket to perform virtual screening with 1200 compounds from the Prestwick library. Seven hits were validated by surface plasmon resonance (SPR) as binders to HLA-A2 as a first step in identifying molecules that can perturb its association with the Ad E3-19K protein.