cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genetic variation associated with circulating monocyte count in the eMERGE Network
Creators: name: Nalls, Michael A.
name: Li, Rongling
name: Weston, Noah
name: Carrell, David S.
name: van Rooij, Frank J.A.
name: Liu, Yongmei
name: Crawford, Dana C.
name: Kullo, Iftikhar J.
name: Ritchie, Marylyn D.
name: Gallego, Carlos J.
name: McCarty, Catherine A.
name: Crosslin, David R.
name: Garcia, Melissa
name: Yango, Qiong
name: Crane, Paul K.
name: Pugh, Elizabeth
name: Hayes, M. Geoffrey
name: Hart, Eugene
name: Couper, David J.
name: Smith, Albert V.
name: McDavid, Andrew
name: de Andrade, Mariza
name: Tanaka, Toshiko
name: Crenshaw, Andrew
name: Zheng, Xiuwen
name: Newton, Katherine
name: Saip, Alexander
name: Doheny, Kimberly F.
name: Zakai, Neil A.
name: Chen, Ming-Huei
name: Mirel, Daniel B.
name: Kho, Abel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: With white blood cell count emerging as an important risk factor for chronic inflammatory diseases, genetic associations of differential leukocyte types, specifically monocyte count, are providing novel candidate genes and pathways to further investigate. Circulating monocytes play a critical role in vascular diseases such as in the formation of atherosclerotic plaque. We performed a joint and ancestry-stratified genome-wide association analyses to identify variants specifically associated with monocyte count in 11 014 subjects in the electronic Medical Records and Genomics Network. In the joint and European ancestry samples, we identified novel associations in the chromosome 16 interferon regulatory factor 8 (IRF8) gene (P-value = 2.78×10(−16), β = −0.22). Other monocyte associations include novel missense variants in the chemokine-binding protein 2 (CCBP2) gene (P-value = 1.88×10(−7), β = 0.30) and a region of replication found in ribophorin I (RPN1) (P-value = 2.63×10(−16), β = −0.23) on chromosome 3. The CCBP2 and RPN1 region is located near GATA binding protein2 gene that has been previously shown to be associated with coronary heart disease. On chromosome 9, we found a novel association in the prostaglandin reductase 1 gene (P-value = 2.29×10(−7), β = 0.16), which is downstream from lysophosphatidic acid receptor 1. This region has previously been shown to be associated with monocyte count. We also replicated monocyte associations of genome-wide significance (P-value = 5.68×10(−17), β = −0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count.
The Bivariate Probit Model, Maximum Likelihood Estimation, Pseudo True Parameters and Partial Identification
Creators: name: Li, Chuhui
name: Poskitt, Donald S.
name: Zhao, Xueyan
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper presents an examination of the finite sample performance of likelihood based estimators derived from different functional forms. We evaluate the impact of
Data-driven particle Filters for particle Markov Chain Monte Carlo
Creators: name: Leung, Patrick
name: Forbes, Catherine S.
name: Martin, Gael M.
name: McCabe, Brendan
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper proposes new automated proposal distributions for sequential Monte Carlo algorithms, including particle filtering and related sequential importance sampling methods. The wrights for these proposal distributions are easily established, as is the unbiasedness property of the resultant likelihood estimators, so that the methods may be used within a particle Markov chain Monte Carlo (PMCMC) inferential setting. Simulation exercises, based on a range of state space models, are used to demonstrate the linkage between the signal-to-noise ratio of the system and the performance of the new particle filters, in comparison with existing filters. In particular, we demonstrate that one of our proposed filters performs well in a high signal-to-noise ratio setting, that is, when the observation is informative in identifying the location of the unobserved state. A second filter, deliberately designed to draw proposals that are informed by both the current observation and past states, is shown to work well across a range of signal-to noise ratios and to be much more robust than the auxiliary particle filter, which is often used as the default choice. We then extend the study to explore the performance of the PMCMC algorithm using the new filters to estimate the likelihood function, once again in comparison with existing alternatives. Taking into consideration robustness to the signal-to-noise ratio, computation time and the efficiency of the chain, the second of the new filters is again found to be the best-performing method. Application of the preferred filter to a stochastic volatility model for weekly Australian/US exchange rate returns completes the paper.
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
Creators: name: Völzke, Henry
name: Teumer, Alexander
name: Sidore, Carlo
name: Ngwa, Julius S.
name: Marazita, Mary L.
name: Crout, Richard J.
name: Wallaschofski, Henri
name: Edward, Lakatta
name: White, Charles
name: Workalemahu, Tsegaselassie
name: Choh, Audrey C.
name: Scheet, Paul
name: Hayes, Richard B.
name: Abecasis, Goncalo R.
name: Schipf, Sabine
name: Heard-Costa, Nancy L.
name: Homuth, Georg
name: Sanna, Serena
name: Xiao, Xiangjun
name: Atwood, Larry D.
name: Graff, Mariaelisa
name: Jacobs, Kevin B.
name: Chanock, Stephen J.
name: Van Dam, Rob M.
name: Czerwinski, Stefan A.
name: Shaffer, John R
name: Hu, Frank
name: Schlessinger, David
name: Wang, Zhaoming
name: Francesco, Cucca
name: Demerath, Ellen W.
name: Fox, Caroline S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10−8) near FTO (P = 3.72 × 10−23), TMEM18 (P = 3.24 × 10−17), MC4R (P = 4.41 × 10−17), TNNI3K (P = 4.32 × 10−11), SEC16B (P = 6.24 × 10−9), GNPDA2 (P = 1.11 × 10−8) and POMC (P = 4.94 × 10−8) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10−5 after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18–90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.
Enhancing triplet superconductivity by the proximity to a singlet superconductor in oxide heterostructures
Creators: name: Horsdal, Mats
name: Khaliullin, Giniyat
name: Hyart, Timo
name: Rosenow, Bernd
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show how in principle a coherent coupling between two superconductors of opposite parity can be realized in a three-layer oxide heterostructure. Due to strong intraionic spin-orbit coupling in the middle layer, singlet Cooper pairs are converted into triplet ones and vice versa. This results in a large enhancement of the triplet superconductivity, persisting well above the native triplet critical temperature.
description: Minor improvements, references added, published version. 5 pages, 3 figures
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia
Creators: name: Reiner, Alexander P.
name: Tracy, Russell P.
name: Baumert, Jens
name: Illig, Thomas
name: März, Winfried
name: Thorand, Barbara
name: Tang, W.H. Wilson
name: Psaty, Bruce M.
name: Consortium, CARDIoGRAM
name: Lange, Leslie A.
name: Keating, Brendan J.
name: Bis, Joshua C.
name: Koenig, Wolfgang
name: Müller-Nurasyid, Martina
name: Fornage, Myriam
name: Erdmann, Jeanette
name: Jacobs, David R.
name: Wild, Philipp S.
name: Blankenberg, Stefan
name: Hartiala, Jaana
name: Kleber, Marcus E.
name: Zeller, Tanja
name: Fontes, João D.
name: Bielinski, Suzette J.
name: Rotter, Jerome I.
name: Rice, Kenneth
name: Ojeda, Francisco
name: Munzel, Thomas F.
name: Dupuis, Josée
name: Schnabel, Renate B.
name: Baldus, Stephan
name: Wilson, James G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated with serum MPO levels in 9305 subjects of European ancestry (lead SNP rs800292; P = 4.89 × 10−41) and in 1690 AA subjects (rs505102; P = 1.05 × 10−8). Gene-centric analyses in 8335 subjects of European ancestry additionally identified two rare MPO coding sequence variants that were associated with serum MPO levels (rs28730837, P = 5.21 × 10−12; rs35897051, P = 3.32 × 10−8). A GWAS for plasma MPO levels in 9260 European ancestry subjects identified a chromosome 17q22 region near MPO that was significantly associated (lead SNP rs6503905; P = 2.94 × 10−12), but the CFH locus did not exhibit evidence of association with plasma MPO levels. Functional analyses revealed that rs800292 was associated with levels of complement proteins in serum. Variants at chromosome 17q22 also had pleiotropic cis effects on gene expression. In a case–control analysis of ∼80 000 subjects from CARDIoGRAM, none of the identified single-nucleotide polymorphisms (SNPs) were associated with CAD. These results suggest that distinct genetic factors regulate serum and plasma MPO levels, which may have relevance for various acute and chronic inflammatory disorders. The clinical implications for CAD and a better understanding of the functional basis for the association of CFH and MPO variants with circulating MPO levels require further study.
Genome-wide association study of age at menarche in African-American women
Creators: name: Hu, J. J.
name: Lu, X.
name: Henderson, B. E.
name: Kerr, K. F.
name: Deming, S. L.
name: Demerath, E. W.
name: Le Marchand, L.
name: Chen, W.
name: Ingles, S.
name: Chen, C. T. L.
name: Arnold, A. M.
name: Franceschini, N.
name: Berenson, G. S.
name: Chen, G.
name: Evans, M. K.
name: Ambrosone, C. B.
name: Britton, A.
name: Chen, Z.
name: Bandera, E. V.
name: Musani, S. K.
name: Kolonel, L. N.
name: Chanock, S. J.
name: John, E. M.
name: Elks, C. E.
name: Gajdos, Z.
name: Bernstein, L.
name: Smith, E. N.
name: Millikan, R. C.
name: Cappola, A. R.
name: Liu, C.-T.
name: Carlson, C. S.
name: Palmer, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: African-American (AA) women have earlier menarche on average than women of European ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among other chronic diseases. Identification of common genetic variants associated with age at menarche has a potential value in pointing to the genetic pathways underlying chronic disease risk, yet comprehensive genome-wide studies of age at menarche are lacking for AA women. In this study, we tested the genome-wide association of self-reported age at menarche with common single-nucleotide polymorphisms (SNPs) in a total of 18 089 AA women in 15 studies using an additive genetic linear regression model, adjusting for year of birth and population stratification, followed by inverse-variance weighted meta-analysis (Stage 1). Top meta-analysis results were then tested in an independent sample of 2850 women (Stage 2). First, while no SNP passed the pre-specified P < 5 × 10−8 threshold for significance in Stage 1, suggestive associations were found for variants near FLRT2 and PIK3R1, and conditional analysis identified two independent SNPs (rs339978 and rs980000) in or near RORA, strengthening the support for this suggestive locus identified in EA women. Secondly, an investigation of SNPs in 42 previously identified menarche loci in EA women demonstrated that 25 (60%) of them contained variants significantly associated with menarche in AA women. The findings provide the first evidence of cross-ethnic generalization of menarche loci identified to date, and suggest a number of novel biological links to menarche timing in AA women.
Reconceptualising Violence in International and Comparative Education: Revisiting Galtung's Framework
Creators: name: Paulson, Julia
name: Tikly, Leon
Publisher: name: Zenodo
Year: 2022

description: Outside of a specialist literature, the study of violence occupies a marginal position within comparative and international education (CIE) scholarship. A key contributing factor is the absence of an holistic conceptual framework that can capture the nature, extent and causes of violence in education. The article proposes such a framework, by updating Johan Galtung’s model of direct, structural and cultural violence by putting them into dialogue with theoretical work from the social sciences and humanities. This dialogue affirms the importance of each form of violence and the interconnections between them but proposes a deeper appreciation of the depth ontology of violence and a reappraisal of Galtung’s ideas about the visibility and invisibilisation of violence. The article explores the utility of the framework by using it to explore the so called ‘learning crisis,’ which it argued may be more accurately considered a crisis of violence.
MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension
Creators: name: Biswas, N.
name: Pravenec, M.
name: Schmid-Schonbein, G. W.
name: Miramontes-Gonzalez, J. P.
name: Vaingankar, S. M.
name: Courel, M.
name: Schork, N. J.
name: Salem, R. M.
name: Jirout, M. L.
name: Gayen, J. R.
name: Altshuler, A. E.
name: O'Connor, D. T.
name: Friese, R. S.
name: Taupenot, L.
name: Kim, H.-S.
name: Ziegler, M. G.
name: Hightower, C. M.
name: Cale, M.
name: Zhang, K.
name: Mahapatra, N. R.
name: Mahata, S. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Hypertension is a common hereditary syndrome with unclear pathogenesis. Chromogranin A (Chga), which catalyzes formation and cargo storage of regulated secretory granules in neuroendocrine cells, contributes to blood pressure homeostasis centrally and peripherally. Elevated Chga occurs in spontaneously hypertensive rat (SHR) adrenal glands and plasma, but central expression is unexplored. In this report, we measured SHR and Wistar–Kyoto rat (control) Chga expression in central and peripheral nervous systems, and found Chga protein to be decreased in the SHR brainstem, yet increased in the adrenal and the plasma. By re-sequencing, we systematically identified five promoter, two coding and one 3′-untranslated region (3′-UTR) polymorphism at the SHR (versus WKY or BN) Chga locus. Using HXB/BXH recombinant inbred (RI) strain linkage and correlations, we demonstrated genetic determination of Chga expression in SHR, including a cis-quantitative trait loci (QTLs) (i.e. at the Chga locus), and such expression influenced biochemical determinants of blood pressure, including a cascade of catecholamine biosynthetic enzymes, catecholamines themselves and steroids. Luciferase reporter assays demonstrated that the 3′-UTR polymorphism (which disrupts a microRNA miR-22 motif) and promoter polymorphisms altered gene expression consistent with the decline in SHR central Chga expression. Coding region polymorphisms did not account for changes in Chga expression or function. Thus, we hypothesized that the 3′-UTR and promoter mutations lead to dysregulation (diminution) of Chga in brainstem cardiovascular control nuclei, ultimately contributing to the pathogenesis of hypertension in SHR. Accordingly, we demonstrated that in vivo administration of miR-22 antagomir to SHR causes substantial (∼18 mmHg) reductions in blood pressure, opening a novel therapeutic avenue for hypertension.
Asymptotic Properties of Approximate Bayesian Computation
Creators: name: Frazier, D.T.
name: Martin, G.M.
name: Robert, C.P.
name: Rousseau, J.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Approximate Bayesian computation (ABC) is becoming an accepted tool for statistical analysis in models with intractable likelihoods. With the initial focus being primarily on the practical import of ABC, exploration of its formal statistical properties has begun to attract more attention. In this paper we consider the asymptotic behaviour of the posterior obtained from ABC and the ensuing posterior mean. We give general results on: (i) the rate of concentration of the ABC posterior on sets containing the true parameter (vector); (ii) the limiting shape of the posterior; and (iii) the asymptotic distribution of the ABC posterior mean. These results hold under given rates for the tolerance used within ABC, mild regularity conditions on the summary statistics, and a condition linked to identification of the true parameters. Important implication of the theoretical results for practitioners of ABC are highlighted.
A comprehensive examination of breast cancer risk loci in African American women
Creators: name: Bandera, Elisa V.
name: John, Esther M.
name: Palmer, Julie R.
name: Olshan, Andrew F.
name: Chanock, Stephen J.
name: Ziegler, Regina G.
name: Press, Michael F.
name: Millikan, Robert C.
name: Chen, Gary K.
name: Hu, Jennifer J.
name: Nyante, Sarah
name: Conti, David V.
name: Ingles, Sue A.
name: Zheng, Wei
name: Ambrosone, Christine B.
name: Kolonel, Laurence N.
name: Easton, Douglas
name: Stram, Alex
name: Park, Karen
name: Henderson, Brian E.
name: Le Marchand, Loic
name: Rhie, Suhn Kyong
name: Ogundiran, Temidayo
name: Stram, Daniel O.
name: Deming, Sandra L.
name: Rodriguez-Gil, Jorge L.
name: Bernstein, Leslie
name: Huo, Dezheng
name: Adebamowo, Clement A.
name: Rand, Kristin A.
name: Feng, Ye
name: Olopade, Olufunmilayo I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Genome-wide association studies have identified 73 breast cancer risk variants mainly in European populations. Given considerable differences in linkage disequilibrium structure between populations of European and African ancestry, the known risk variants may not be informative for risk in African ancestry populations. In a previous fine-mapping investigation of 19 breast cancer loci, we were able to identify SNPs in four regions that better captured risk associations in African American women. In this study of breast cancer in African American women (3016 cases, 2745 controls), we tested an additional 54 novel breast cancer risk variants. Thirty-eight variants (70%) were found to have an association with breast cancer in the same direction as previously reported, with eight (15%) replicating at P < 0.05. Through fine-mapping, in three regions (1q32, 3p24, 10q25), we identified variants that better captured associations with overall breast cancer or estrogen receptor positive disease. We also observed suggestive associations with variants (at P < 5 × 10−6) in three separate regions (6q25, 14q13, 22q12) that may represent novel risk variants. Directional consistency of association observed for ∼65–70% of currently known genetic variants for breast cancer in women of African ancestry implies a shared functional common variant at most loci. To validate and enhance the spectrum of alleles that define associations at the known breast cancer risk loci, as well as genome-wide, will require even larger collaborative efforts in women of African ancestry.
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2
Creators: name: Wen, Wanqing
name: Park, Eun Jung
name: Chen, Peng
name: Gan, Wei
name: Gao, He
name: Lee, Jeannette J.M.
name: Sheu, Wayne H-H.
name: Osawa, Haruhiko
name: Kawamoto, Ryuichi
name: Liu, Jianjun
name: Nakatochi, Masahiro
name: Hwu, Chii-Min
name: Jo, Jaeseong
name: Lu, Ling
name: Fogarty, Marie P.
name: Kuzawa, Christophor W.
name: He, Chih-Tsueng
name: Chiu, Yen-Feng
name: Teo, Yvonne
name: Mcdade, Thomas W.
name: Tabara, Yasuharu
name: Li, Huaixing
name: Hsiung, Chao A.
name: Kato, Norihiro
name: Igase, Michiya
name: Ichihara, Sahoko
name: Croteau-Chonka, Damien C.
name: Chang, Yi-Cheng
name: Borja, Judith B.
name: Cai, Qiuyin
name: Wu, Ying
name: Adair, Linda S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10−14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10−7). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10−165), ADIPOQ (P = 1.8 × 10−22), PEPD (P = 3.6 × 10−12), CMIP (P = 2.1 × 10−10), ZNF664 (P = 2.3 × 10−7) and GPR109A (P = 7.4 × 10−6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10−7). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P = 3.3 × 10−4), high density lipoprotein cholesterol (HDL-C, P = 4.9 × 10−4) and body mass index (BMI)-adjusted waist–hip ratio (P = 9.8 × 10−3). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms.
MPEC 2023-U161 : 2023 UN3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UN3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Étude, conception et réalisation d’un prototype de bras bionique controlé par électromyographie pour les amputations transradiales
Creators: name: Bedraoui, Anas
name: Abdelmajid, Hajami
name: Rguibi, Zakaria
Publisher: name: figshare
Year: 2022
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 90303 Biomedical Instrumentation
subject: 90399 Biomedical Engineering not elsewhere classified
subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences
subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90304 Medical Devices
subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: Ces dernières années, des progrès et des développements remarquables ont été accomplis dans le domaine de la technologie des prothèses de membres supérieurs. De nombreux individus souffrent de handicaps qui les empêchent d’accomplir leurs activités quotidiennes normales. Des statistiques récentes montrent que 57,7 millions d’individus vivent avec des amputations de membres dues à des causes traumatiques dans le monde entier. Des études récentes indiquent que la prévalence de l’amputation était de 1,6 million en 2005 et qu’elle devrait doubler d’ici 2050. Il existe de nombreux types de prothèses. Certaines ne sont faites que pour l’esthétique, tandis que d’autres sont fonctionnelles et peuvent principalement aider le patient dans ses activités quotidiennes. La capacité de contrôle est ce qui fait la différence lorsqu’il s’agit de choisir le bon dispositif. Le signal EMG est aujourd’hui la meilleure solution pour contrôler un bras bionique. L’objectif principal de ce projet est de construire un prototype de bras bionique abordable pour la majorité des marocains et contrôlé par l’activité électrique du muscle. Pour atteindre cet objectif, nous avons conçu, fabriqué et testé un prototype de bras bionique. Ce rapport présente les résultats du test du prototype de bras bionique et présente également les perspectives de futures recherches.
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
Creators: name: McClay, Joseph L.
name: Magnusson, Patrik K.E.
name: Xie, Lin Y.
name: Nerella, Srilaxmi
name: Hudson, Alexandra D.
name: Clark, Shaunna L.
name: Hultman, Christina M.
name: Aberg, Karolina A.
name: Sullivan, Patrick F.
name: Harada, Aki
name: Van Den Oord, Edwin J.C.G.
name: Kumar, Gaurav
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA from 718 individuals, aged 25–92 years (mean = 55). We sequenced the methyl-CpG-enriched genomic DNA fraction, averaging 67.3 million reads per subject, to obtain methylation measurements for the ∼27 million autosomal CpGs in the human genome. Following extensive quality control, we adaptively combined methylation measures for neighboring, highly-correlated CpGs into 4 344 016 CpG blocks with which we performed association testing. Eleven age-associated differentially methylated regions (DMRs) passed Bonferroni correction (P-value < 1.15 × 10−8). Top findings replicated in an independent sample set of 558 subjects using pyrosequencing of bisulfite-converted DNA (min P-value < 10−30). To examine biological themes, we selected 70 DMRs with false discovery rate of <0.1. Of these, 42 showed hypomethylation and 28 showed hypermethylation with age. Hypermethylated DMRs were more likely to overlap with CpG islands and shores. Hypomethylated DMRs were more likely to be in regions associated with polycomb/regulatory proteins (e.g. EZH2) or histone modifications H3K27ac, H3K4m1, H3K4m2, H3K4m3 and H3K9ac. Among genes implicated by the top DMRs were protocadherins, homeobox genes, MAPKs and ryanodine receptors. Several of our DMRs are at genes with potential relevance for age-related disease. This study successfully demonstrates the application of next-generation sequencing to MWAS, by interrogating a large proportion of the methylome and returning potentially novel age DMRs, in addition to replicating several loci implicated in previous studies using microarrays.
Environmental enrichment and winter garden in a turkey barn
Creators: name: EURCAW-Poultry-SFA
Publisher: name: Zenodo
Year: 2023
Subjects: Good practice
Turkeys
Enrichment
Winter garden
Covered veranda

description: The EURCAW Poultry-SFA visited a turkey barn with a winter garden and environmental enrichment (straw bales, elevated platforms, plastic jugs and bottles, strings, and pecking blocks). These additions allow for the production of turkeys without mutilations (intact beak and toes), improving their welfare. A winter garden and natural light indoors were added to this 1000 m² barn dating from the 1980s. For a few years, a partnership with a farm animal welfare NGO has helped to develop a better living environment for the turkeys. During the visit, the birds were 71 days old and, a slower-growing strain was being tested. Previously, a white fast-growing strain was housed in the same conditions. The document is available in English, French, German, Italian, and Spanish.
Cosmic evolution of scalar fields with multiple vacua: generalized DBI and quintessence
Creators: name: Gao, Changjun
name: Shen, You-Gen
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We find a method to rewrite the equations of motion of scalar fields, generalized DBI field and quintessence, in the autonomous form for\emph{arbitrary} scalar potentials. With the aid of this method, we explore the cosmic evolution of generalized DBI field and quintessence with the potential of multiple vacua. Then we find that the scalars are always frozen in the false or true vacuum in the end. Compared to the evolution of quintessence, the generalized DBI field has more times of oscillations around the vacuum of the potential. The reason for this point is that, with the increasing of speed $\dotϕ$, the friction term of generalized DBI field is greatly decreased. Thus the generalized DBI field acquires more times of oscillations.
description: 8 pages, 9 figures, accepted by IJTP. A number of typos corrected
Another Look at Single-Index Models Based on Series Estimation
Creators: name: Dong, Chaohua
name: Gao, Jiti
name: Peng, Bin
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: In this paper, a semiparametric single-index model is investigated. The link function is allowed to be unbounded and has unbounded support that answers a pen ding issue in the literature. Meanwhile, the link function is treated as a point in an infinitely many dimensional function space which enables us to derive the estimates for the index parameter and the link function simultaneously. This approach is different from the profile method commonly used in the literature. The estimator is derive d from an optimization with the constraint of identification condition for index parameter, which is a natural way but ignored in the literature.
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
Creators: name: Perreault, L.-P. L.
name: Maher, B. S.
name: Bellini, S.
name: Craddock, N.
name: O'Callaghan, E.
name: Scolnick, E.
name: Molinos, I.
name: Freeman, C.
name: Ennis, S.
name: Elves, R. L.
name: Kenny, E. M.
name: Thiselton, D. L.
name: Walsh, D.
name: Cormican, P.
name: Waddington, J. L.
name: Dinan, T. G.
name: Stone, J.
name: McDonald, C.
name: Regan, R.
name: Grozeva, D.
name: Wormley, B.
name: Morris, D. W.
name: Kelleher, E.
name: Strange, A.
name: O'Dushlaine, C. T.
name: Giannoulatou, E.
name: Fahey, C.
name: Pirinen, M.
name: O'Donovan, M.
name: Murphy, K. C.
name: Pearson, R. D.
name: Tropea, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Identifying rare, highly penetrant risk mutations may be an important step in dissecting the molecular etiology of schizophrenia. We conducted a gene-based analysis of large (>100 kb), rare copy-number variants (CNVs) in the Wellcome Trust Case Control Consortium 2 (WTCCC2) schizophrenia sample of 1564 cases and 1748 controls all from Ireland, and further extended the analysis to include an additional 5196 UK controls. We found association with duplications at chr20p12.2 (P = 0.007) and evidence of replication in large independent European schizophrenia (P = 0.052) and UK bipolar disorder case-control cohorts (P = 0.047). A combined analysis of Irish/UK subjects including additional psychosis cases (schizophrenia and bipolar disorder) identified 22 carriers in 11 707 cases and 10 carriers in 21 204 controls [meta-analysis Cochran–Mantel–Haenszel P-value = 2 × 10−4; odds ratio (OR) = 11.3, 95% CI = 3.7, ∞]. Nineteen of the 22 cases and 8 of the 10 controls carried duplications starting at 9.68 Mb with similar breakpoints across samples. By haplotype analysis and sequencing, we identified a tandem ∼149 kb duplication overlapping the gene p21 Protein-Activated Kinase 7 (PAK7, also called PAK5) which was in linkage disequilibrium with local haplotypes (P = 2.5 × 10−21), indicative of a single ancestral duplication event. We confirmed the breakpoints in 8/8 carriers tested and found co-segregation of the duplication with illness in two additional family members of one of the affected probands. We demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity.
A Quantile Regression Approach to Panel Data Analysis of Health Care Expenditure in OECD Countries
Creators: name: Tian, Fengping
name: Gao, Jiti
name: Yang, Ke
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This article investigates the variation in the effects of various determinants on the per capita health care expenditure. A total of 28 OECD countries are studied over the period 1990-2012, employing an instrumental variable quantile regression method for a dynamic panel model with fixed effects. The results show that the determinants of per capita health care expenditure do vary with the distribution of the health care expenditure growth, while the change patterns are dissimilar. Specifically, the lagged health spending growth has a significantly positive effect, with an effect that decreases towards the higher quantiles of growth of per capita health care expenditure. Per capita GDP has a significantly positive effect, both the short and long run income elasticities are smaller than one, and health care is a necessity. The density of physicians only has a significant negative effect at the lower tail of the distribution. The elderly population has the reverse effect at the lower and upper tails, and this shows an upward trend with the increase in health expenditure growth. Life expectancy has an effect similar to the proportion of the old. Variable representing Baumol's model of "unbalanced growth" theory has a significantly positive effect, and the change pattern of its influence shows a marked upward trend. However, one component of "Baumol variable", labor productivity, only shows significant effect in the low half of the distribution. More attention needs to be paid to the influence of determinants in health expenditure study.
Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP
Creators: name: Patterson, Cam
name: Sun, Shi-Lei
name: McDonough, Holly
name: Wang, Rui-Hao
name: Schisler, Jonathan C.
name: Portbury, Andrea L.
name: Tan, Song
name: True, Cadence
name: Mao, Cheng-Yuan
name: Seminara, Stephanie B.
name: Shi, Chang-He
name: Xu, Lei
name: Wang, Qing-Zhi
name: Xu, Yu-Ming
name: Song, Bo
name: Rubel, Carrie E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Gordon Holmes syndrome (GHS) is a rare Mendelian neurodegenerative disorder characterized by ataxia and hypogonadism. Recently, it was suggested that disordered ubiquitination underlies GHS though the discovery of exome mutations in the E3 ligase RNF216 and deubiquitinase OTUD4. We performed exome sequencing in a family with two of three siblings afflicted with ataxia and hypogonadism and identified a homozygous mutation in STUB1 ({"type":"entrez-nucleotide","attrs":{"text":"NM_005861","term_id":"645912988","term_text":"NM_005861"}}NM_005861) c.737C→T, p.Thr246Met, a gene that encodes the protein CHIP (C-terminus of HSC70-interacting protein). CHIP plays a central role in regulating protein quality control, in part through its ability to function as an E3 ligase. Loss of CHIP function has long been associated with protein misfolding and aggregation in several genetic mouse models of neurodegenerative disorders; however, a role for CHIP in human neurological disease has yet to be identified. Introduction of the Thr246Met mutation into CHIP results in a loss of ubiquitin ligase activity measured directly using recombinant proteins as well as in cell culture models. Loss of CHIP function in mice resulted in behavioral and reproductive impairments that mimic human ataxia and hypogonadism. We conclude that GHS can be caused by a loss-of-function mutation in CHIP. Our findings further highlight the role of disordered ubiquitination and protein quality control in the pathogenesis of neurodegenerative disease and demonstrate the utility of combining whole-exome sequencing with molecular analyses and animal models to define causal disease polymorphisms.
MOESM1 of Socioeconomic status of patients in a Swedish national self-management program for osteoarthritis compared with the general population—a descriptive observational study
Creators: name: Gustafsson, Kristin
name: Kvist, Joanna
name: Eriksson, Marit
name: Dahlberg, Leif
name: Rolfson, Ola
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Description of the nine indicators of socioeconomic status (SES) used in the study.
Analytical Theory of Neutrino Oscillations in Matter with CP violation
Creators: name: Johnson, Mikkel B.
name: Henley, Ernest M.
name: Kisslinger, Leonard S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We develop an exact analytical formulation of neutrino oscillations in matter within the framework of the Standard Neutrino Model assuming 3 Dirac Neutrinos. Our Hamiltonian formulation, which includes CP violation, leads to expressions for the partial oscillation probabilities that are linear combinations of spherical Bessel functions in the eigenvalue differences. The coefficients of these Bessel functions are polynomials in the neutrino CKM matrix elements, the neutrino mass differences squared, the strength of the neutrino interaction with matter, and the neutrino mass eigenvalues in matter. We give exact closed-form expressions for all partial oscillation probabilities in terms of these basic quantities. Adopting the Standard Neutrino Model, we then examine how the exact expressions for the partial oscillation probabilities might simplify by expanding in one of the small parameters α and sinθ13 of this model. We show explicitly that for small α and sinθ13 there are branch points in the analytic structure of the eigenvalues that lead to singular behavior of expansions near the solar and atmospheric resonances. We present numerical calculations that indicate how to use the small-parameter expansions in practice.
description: 27 pages, 8 figures, minor typos corrected
title: Adressbuch der Stadt Zürich für 1902
title: Adressbuch Zürich
titleType: AlternativeTitle
title: Adressbuch Stadt Zürich
titleType: AlternativeTitle
title: Mit einem Plan von Zürich und Umgebung, sowie einem Plane des Stadttheaters und der Tonhalle und einem Strassenverzeichnis.
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Orell Füssli
Year: 1902
Subjects: subject: 330 Wirtschaft
subject: Zürich
subject: Adressbuch

description: Im Stadtplan von Zürich fehlt die obere linke Ecke.
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
Creators: name: Pato, M.
name: Chambert, K. D.
name: Kirov, G.
name: Moran, J. L.
name: Morris, D. W.
name: Sklar, P.
name: Gill, M.
name: Georgieva, L.
name: O'Dushlaine, C.
name: McCarroll, S. A.
name: Hultman, C.
name: Genovese, G.
name: Cormican, P.
name: Mahoney-Davies, G.
name: Richards, A. L.
name: Walters, J. T. R.
name: Pato, C.
name: Corvin, A.
name: Riley, B.
name: Owen, M. J.
name: Kendler, K. S.
name: Sullivan, P. F.
name: O'Donovan, M. C.
name: Legge, S. E.
name: Szatkiewicz, J.
name: O'Neill, F. A.
name: Rees, E.
name: Levinson, D.
name: Gejman, P. V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 cases and 11 255 controls genotyped on Illumina arrays, most of which have not been used for this purpose before. We identified genes enriched for rare exonic CNVs among cases, and then attempted to replicate the findings in additional 14 568 cases and 15 274 controls. In a combined analysis of all samples, 12 distinct loci were enriched among cases with nominal levels of significance (P < 0.05); however, none would survive correction for multiple testing. These loci include recurrent deletions at 16p12.1, a locus previously associated with neurodevelopmental disorders (P = 0.0084 in the discovery sample and P = 0.023 in the replication sample). Other plausible candidates include non-recurrent deletions at the glutamate transporter gene SLC1A1, a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1. A burden analysis of large (>500 kb), rare CNVs showed a 1.2% excess in cases after excluding known schizophrenia-associated loci, suggesting that additional susceptibility loci exist. However, even larger samples are required for their discovery.
Supplementary document for Superposition Fabry-Perot filter array for computational hyperspectral camera - 6273458.pdf
Creators: name: Feng, Shiqi
name: Wang, Zhanshan
name: Cheng, Xinbin
name: Dun, Xiong
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: supplementary 1
title: Using Technology-Enabled Learning Networks To Achieve Practical Improvement Outcomes In The UK Open University
Creators: name: Boyd, Lesley
Publisher: name: The Open University
Year: 2022

description: Collaborative learning technology is becoming ubiquitous across the globe for academic learning or professional development. However it also affords dispersed practitioners the ability to grapple together with a problem area requiring improvement. This process requires mutual and reflective learning so that each participant can bring to bear their professional viewpoint, experience and insights to the problem at hand. However, there is insufficient conceptual and practical understanding about how this unfolding process might happen. This thesis explores how technology-enabled learning networks can be used to achieve practical improvement outcomes amongst disparate and geographically separated practitioners. It is situated within a challenging learning design and delivery scenario in the UK Open University, a Higher Education (HE) distance learning context. The research investigated what practical improvement outcomes could be achieved; how the mechanisms of using technology-enabled learning networks to achieve improvement outcomes can best be conceptualised in the practice environment; and what factors enable or constrain the achievement of these outcomes. By embracing an insider action research and theory-building combined approach, the research both enacted and conceptualised a collaborative and equitable Pragmatic Inquiry process, and successfully demonstrated measurable impact. The new conceptual framework is entitled ULTIMATE - Using Learning Technology in Making Action-based Transformative Enhancements. ULTIMATE provides an enacting framework for a structured, flexible and recoverable collaborative action research process which can be used by practitioners and be systematically and rigorously extended to other contexts. A successful ULTIMATE learning network will consist of learning technology infrastructure integrated with this action research process, and with engaged individual participation based on problem-solving role or interest. Together, they provide a means for a profound and ethical shift in the way that disparate and geographically separated practitioners and stakeholders can share their experiences, mutually transform, and address complex fragmented practical challenges in HE and beyond.