title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð¾Ð´Ð½Ð¾Ð³Ð¾ ÐºÐ°Ð½Ð°Ð»Ð° Ð°ÐºÐ²Ð°Ð¿Ð¾ÑÐ¸Ð½Ð°-4 Ð½Ð° ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð¸ Ð² Ð½Ð¸Ð³ÑÐ¾ÑÑÑÐ¸Ð°ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ Ð¿ÑÐ¸ Ð¿ÑÐ¾ÑÐµÐ°ÑÐ¾Ð¼Ð½Ð¾Ð¹ Ð´Ð¸ÑÑÑÐ½ÐºÑÐ¸Ð¸ Ñ ÐºÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Influence of aquaporin-4 water channel inhibition on the development of neuro-degeneration in the nigrostriatal system during proteasome dysfunction in rats
Creators: name: ÐÐ±ÑÐ°Ð¼Ð¾Ð²Ð°, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð°ÐºÐ²Ð°Ð¿Ð¾ÑÐ¸Ð½-4
ÑÐ±Ð¸ÐºÐ²Ð¸ÑÐ¸Ð½-Ð¿ÑÐ¾ÑÐµÐ°ÑÐ¾Ð¼Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð°
Ð³Ð»Ð¸Ð¼ÑÐ°ÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ¸ÑÑÐµÐ¼Ð°
Ð±Ð¾-Ð»ÐµÐ·Ð½Ñ Ð¿Ð°ÑÐºÐ¸Ð½ÑÐ¾Ð½Ð°
Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ñ
aquaporin-4
ubiquitin-proteasome system
glymphatic system
parkinson's disease
neurodegeneration

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description: The subject of the graduate qualification work is âInfluence of aquaporin-4 water channel inhibition on the development of neurodegeneration in the nigrostriatal system during proteasome dysfunction in ratsâ. Water channel aquaporin-4 is a very important component of the glymphatic system which provides the elimination of metabolites (particularly amyloid proteins) from the brain. Our study was aimed to evaluate the effect of inhibition of aquaporin 4 on the development of neurodegeneration in the nigrostriatal system in the lactacystin (LC) model of the preclinical stage of PD. Aquaporin-4 was inhibited using the inhibitor TGN-020, the model of the preclinical stage of PD was reproduced using the proteasome inhibitor lactacystin (LÐ¡). To assess the neurodegenerative changes and motor impairment the immuhistochemical methods and behavioral tests were applied. The pretreatment with TGN-020 accelerated the neurodegeneration in nigrostriatal system, led to a decrease in the level of tyrosine hydroxylase in nigral neurons and caused motor dysfunction in model animals. These patterns may reflect the transition of the preclinical stage of PD to the early clinical, and we suppose that aquaporin-4 can play an important role in the molecular mechanisms protecting brain functions from neurotoxic factors.