cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DOWNLOAD [PDF] {EPUB} Seasons Tome 1
Creators: name: Wilson
Publisher: name: Zenodo
Year: 2024

description: Seasons Tome 1 pan Morgane Moncomble

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Seasons Tome 1

Morgane Moncomble

Nb. de pages: 256

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782755669398

Editeur: Hugo Roman

Date de parution: 2023

 

 

 

Téléchargement gratuit de livres audio pour ipod touch Seasons Tome 1 (French Edition) 9782755669398 par Morgane Moncomble DJVU

 

Overview

Avocate en devenir, Camelia est passionnée de crimes non résolus. Ca tombe bien, Rory Cavendish, son ancien bourreau, vient de mourir mystérieusement. Le présumé coupable du meurtre, c'est lui. Lou McAllister. Le meilleur ami de Rory. Le garçon qui l'a humiliée il y a dix ans et qu'elle n'a jamais oublié depuis. Camelia saisit cette chance pour résoudre sa première enquête... et satisfaire sa soif de vengeance. Lou a toujours été le mouton noir de sa famille, mais il ne s'attendait pas à finir en prison pour meurtre. Du jour au lendemain, le voilà abandonné par tous ceux en qui il avait confiance. La seule personne à pouvoir le sortir de là, c'est elle. Camelia O'Brien. La première victime de Rory. La fille qu'il a blessée plus jeune et qui hante ses pensées depuis. Lou est prêt à tout pour se faire pardonner ses péchés... et repartir de zéro.
Investigation of Dust Ion Acoustic Shock and Solitary Waves in a Viscous Dusty Plasma
Creators: name: Goswami, J.
name: Kausik, S. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A viscous dusty plasma containing Kappa distributed electrons, positive warm viscous ions and constant negatively charged dust grains with viscosity have been considered to study the modes of dust ion acoustic waves (DIAWs) theoretically and numerically. The derivations and basic features of shock and solitary waves with different plasma parameters like Mach number, finite temperature coefficient, unperturbed dust streaming velocity, kinematic viscosity of dust etc. of this DIAWs mode have been performed. Considering the dynamical equation from Korteweg de Vries(KdV) equation, a phase portrait has been drawn and the position of saddle point or col. and center have also been discussed. This type of dusty plasma can be found in celestial bodies. The results of this research work can be applied to study the properties of DIAWs in various astrophysical situations where Kappa distributive electrons are present and careful modification of the same model can help us to understand the nature of the DIAWs of laboratory plasma as well.
Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at $1.4
Creators: name: Mei, Simona
name: Hatch, Nina A.
name: Amodeo, Stefania
name: Afanasiev, Anton V.
name: De Breuck, Carlos
name: Stern, Daniel
name: Cooke, Elizabeth A.
name: Gonzalez, Anthony H.
name: Noirot, Gaël
name: Rettura, Alessandro
name: Seymour, Nick
name: Stanford, Spencer A.
name: Vernet, Joël
name: Wylezalek, Dominika
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: (Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3
description: 31 pages, 22 figures, A&A, in press
On the saturation of late-time growth of complexity in supersymmetric JT gravity
Creators: name: Alishahiha, Mohsen
name: Banerjee, Souvik
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we use the modified replica trick, proposed in arXiv:2205.01150, to compute the late time behaviour of complexity for JT gravity with ${\cal N} = 1$ and ${\cal N} = 2$ supersymmetries. For the ${\cal N} = 1$ theory, we compute the late time behaviour of complexity defined by the ``quenched geodesic length" and obtain the expected saturation of complexity at time $t \sim e^{S_0}$, to a constant value with time-independent variance. For the ${\cal N} = 2$ theory, we explicitly compute complexity at the disk level which yields the late-time linear growth of complexity. However, we comment on the expectation of the late-time saturation by speculating the trumpet partition function and the non-perturbative corrections to the spectral correlation, relevant for the late-time behaviour of complexity. Furthermore, we compute the matter correlation functions for both the theories.
description: 30 pages, 2 figures
ENHANCING SUPPLY CHAIN AGILITY AND SUSTAINABILITY THROUGH MACHINE LEARNING
Creators: name: Vikram Pasupuleti
Publisher: name: Zenodo
Year: 2024

description: Consequently, the present research study aims to explore how machine learning prospects enhance the dynamic and resilience of the supply chain networks that have been affected by modern circumstances. In this case, both forms of machine learning; supervised and unsupervised were applied; linear regression, recurrent neural networks LSTMs, and feedforward neural networks with attention. Thus, this paper also describes how these models can be useful in improving demand forecasting, risk assessment, and inventory management. We discovered that extended linear regression was well appropriate for short-time demand forecasting the moment limitations became visible when the model had to handle intricate and multiple tasks. In contrast to the other models, the LSTM models are much higher in terms of time series forecasts on the fluctuations and helped minimize the shock of the supply chain. An enhanced feedforward neural network with attention mechanisms enhanced the interpretative ability of the model and the important aspects that are required in transporter delays or suppliers’ performances. Data preprocessing was okay to preprocess being to have the models run at their optimum. Altogether, the present research provides a comparative analysis of different approaches to the classification of data using the methods of machine learning that are essential for the improvement of the models of supply chain that seem to be more resistant and efficient. Thus, supplementing the findings of existing studies that examined the use of predictive analytics in supply chain management, the ideas put forward in this paper provide evidence for the opinions that can be found in previous work regarding the growing importance of machine learning to address new challenges in supply chain management.
Hidden Markov models for stochastic thermodynamics
Creators: name: Bechhoefer, John
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The formalism of state estimation and hidden Markov models (HMMs) can simplify and clarify the discussion of stochastic thermodynamics in the presence of feedback and measurement errors. After reviewing the basic formalism, we use it to shed light on a recent discussion of phase transitions in the optimized response of an information engine, for which measurement noise serves as a control parameter. The HMM formalism also shows that the value of additional information shows a maximum at intermediate signal-to-noise ratios. Finally, we discuss how systems open to information flow can apparently violate causality; the HMM formalism can quantify the performance gains due to such violations.
description: 27 pages, 13 figures; submitted to New J. Phys
A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors
Creators: name: McColl, Kenneth E.L.
name: Blot, William J.
name: Chow, Wong Ho
name: Mowat, N. Ashley G.
name: Vaughan, Thomas L.
name: Lissowska, Jolanta
name: Zatonski, Witold
name: Smith, Malcolm G.
name: Schoenberg, Janet B.
name: Rabkin, Charles S.
name: Hold, Georgina L.
name: Gammon, Marilie D.
name: Fraumeni Jr., Joseph F.
name: El-Omar, Emad M.
name: Risch, Harvey A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND AND AIMS: TLR4 is a cell-surface signaling receptor involved in the recognition and host response to Helicobacter pylori. The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis.

METHODS: We assessed associations with premalignant gastric changes in 149 relatives of gastric cancer patients, including 45 with hypochlorhydria and gastric atrophy. We also genotyped 2 independent Caucasian population-based case-control studies of upper gastrointestinal tract cancer, initially in 312 noncardia gastric carcinoma cases and 419 controls and then in 184 noncardia gastric carcinomas, 123 cardia carcinomas, 159 esophageal cancers, and 211 frequency-matched controls. Odds ratios were computed from logistic models and adjusted for potential confounding factors.

RESULTS: TLR4+896G carriers had an 11-fold (95% confidence interval [CI], 2.5-48) increased odds ratio (OR) for hypochlorhydria; the polymorphism was unassociated with gastric acid output in the absence of H pylori infection. Carriers also had significantly more severe gastric atrophy and inflammation. Seventeen percent of gastric carcinoma patients in the initial study and 15% of the noncardia gastric carcinoma patients in the replication study had 1 or 2 TLR4 variant alleles vs 8% of both control populations (combined OR = 2.3; 95% CI = 1.6-3.4). In contrast, prevalence of TLR4+896G was not significantly increased in esophageal squamous cell (2%, OR = 0.2) or adenocarcinoma (9%, OR = 1.4) or gastric cardia carcinoma (11%, OR = 1.4).

CONCLUSIONS: Our data suggest that the TLR4+896A>G polymorphism is a risk factor for noncardia gastric carcinoma and its precursors. The findings underscore the role of the host innate immune response in outcome of H pylori infection.
(3017) Annie Haycock Butler
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Phase I Study of Visilizumab, a Humanized Anti-CD3 Monoclonal Antibody, in Severe Steroid-Refractory Ulcerative Colitis
Creators: name: Lowder, James
name: Van Assche, Gert
name: Hommes, Daniel
name: Mayer, Lloyd
name: Sandborn, William
name: Targan, Stephan
name: Hanauer, Stephen
name: Mahadevan, Uma
name: Salzberg, Bruce
name: Plevy, Scott
name: Frankel, Matthew
name: Regueiro, Miguel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND & AIMS: To evaluate the safety and biological activity of visilizumab (a humanized anti-CD3 monoclonal antibody) and to determine a maximum tolerated dose in patients with severe ulcerative colitis that had not responded to 5 days of treatment with intravenous corticosteroids.

METHODS: In this open-label phase 1 study, 32 subjects received visilizumab at a dose of 10 or 15 microg/kg, administered intravenously on 2 consecutive days. Clinical response was defined as a Modified Truelove and Witts Severity Index <10 with a minimum decrease of 3 points; remission was <4 points. Endoscopic remission was a Mayo endoscopic subscore of 0 or 1.

RESULTS: Eight patients received 15 microg/kg visilizumab. Because of dose-limiting toxicities (T-cell recovery >30 days in 2 of 8 patients), the dose was reduced to 10 microg/kg in 24 patients. On day 30, 84% of patients demonstrated a clinical response, 41% achieved clinical remission, and 44% achieved endoscopic remission. Forty-five percent of patients did not require salvage therapies or colectomy during the first year postdose. Mild to moderate symptoms of cytokine release occurred in 100% and 83% of patients in the 15- and 10-microg/kg dose groups, respectively. All patients exhibited a rapid decrease in circulating CD4(+) T-cell counts, which returned to baseline values by day 30 in 26 of 30 evaluable patients (86%). There were no serious infections.

CONCLUSIONS: Visilizumab had an acceptable safety profile at the 10-microg/kg dose level and may be clinically beneficial in patients with severe intravenous corticosteroid-refractory ulcerative colitis.
Figure S1 from Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference.
Creators: name: Jacquot, Maude
name: Nomikou, Kyriaki
name: Palmarini, Massimo
name: Mertens, Peter
name: Biek, Roman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes. Diffusion models using continuous space revealed that terrestrial habitat below 300 m altitude, wind direction and higher livestock densities were associated with faster BTV movement. Results of discrete phylogeographic analysis involving generalized linear models broadly supported these findings, but varied considerably with the level of spatial partitioning. Contrary to common perception, we found no evidence for average temperature having a positive effect on BTV diffusion, though both methodological and biological reasons could be responsible for this result. Our study provides important insights into the drivers of BTV transmission at the landscape scale that could inform predictive models of viral spread and have implications for designing control strategies.
Are you willing to assess vulnerability to food fraud?
Creators: name: Kowalska, Aleksandra
Publisher: name: Zenodo
Year: 2022
Subjects: food fraud, food supplements, food market, vulnerability assessment

description: This presentation is the outcome of a research published here: Kowalska, A., Bieniek, M., & Manning, L. (2019). Food supplements’ non-conformity in Europe – Poland: A case study. Trends in Food Science & Technology, 93, 262-270. The research was funded by the National Science Centre, Poland, grant no. 2018/02/X/HS4/03322.
description: {"references": ["Kowalska, A., Bieniek, M., & Manning, L. (2019). Food supplements' non-conformity in Europe \u2013 Poland: A case study. Trends in Food Science & Technology, 93, 262-270. https://doi.org/10.1016/j.tifs.2019.09.022.", "Manning, L., Bieniek, M., Kowalska, A., & Ward, R. (2021). Dietary supplements, harm associated with synthetic adulterants and potential governance solutions. Crime Law and Social Change. https://doi.org/10.1007/s10611-021-09992-9."]}
A Randomized, Placebo-Controlled, Phase II Study of Tetomilast in Active Ulcerative Colitis
Creators: name: Schreiber, Stefan
name: Guzman, Juan P.
name: Keshavarzian, Ali
name: Isaacs, Kim L.
name: Orlandi, Cesare
name: Hanauer, Stephen B.
name: Schollenberger, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND & AIMS: Tetomilast (OPC-6535), a novel thiazole compound, inhibits phosphodiesterase-4 and proinflammatory functions of leukocytes including superoxide production and cytokine release.

METHODS: One hundred eighty-six patients with mildly to moderately active ulcerative colitis (Disease Activity Index [DAI] 4-11 points) from 35 centers were randomized to receive an oral, once-daily dose of placebo or tetomilast 25 mg or 50 mg for 8 weeks.

RESULTS: Percentages of patients reaching the primary end point (improvement as defined by reduction in DAI > or =3 at week 8) were not significantly different between placebo (35%) and either the 25 mg tetomilast (52%) or the 50 mg tetomilast (39%) groups (intent-to-treat population). Remission rates (DAI 0-1) were 7%, 16%, and 21%, respectively (not significant). Mean reduction in DAI at week 8 was greater in the 25-mg group than under placebo (2.8 +/- 0.4 vs 1.7 +/- 0.36, respectively, P = .041) and approached statistical significance in the 50-mg group (2.8 +/- 0.46, P = .056). A post hoc analysis focusing on patients with high activity scores (baseline DAI 7-11) suggested differences between tetomilast and placebo that will require further investigation. No significant safety concerns were raised. Main adverse effects included gastrointestinal problems (nausea, vomiting) and were preferentially seen in the 50-mg tetomilast group.

CONCLUSIONS: This phase II trial of tetomilast in ulcerative colitis did not achieve statistical significance for the primary end point. Secondary end points indicate a potential clinical activity of tetomilast. The post hoc analysis suggests that further clinical development should focus on patients with objective parameters of inflammation.
An STDP-Based Supervised Learning Algorithm for Spiking Neural Networks
Creators: name: Hu, Zhanhao
name: Wang, Tao
name: Hu, Xiaolin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Compared with rate-based artificial neural networks, Spiking Neural Networks (SNN) provide a more biological plausible model for the brain. But how they perform supervised learning remains elusive. Inspired by recent works of Bengio et al., we propose a supervised learning algorithm based on Spike-Timing Dependent Plasticity (STDP) for a hierarchical SNN consisting of Leaky Integrate-and-fire (LIF) neurons. A time window is designed for the presynaptic neuron and only the spikes in this window take part in the STDP updating process. The model is trained on the MNIST dataset. The classification accuracy approach that of a Multilayer Perceptron (MLP) with similar architecture trained by the standard back-propagation algorithm.
[PDF] 100 idées pour développer la psychomotricité des enfants download
Creators: name: Morgan
Publisher: name: Zenodo
Year: 2024

description: 100 idées pour développer la psychomotricité des enfants pan Aurélien D'Ignazio, Juliette Martin

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100 idées pour développer la psychomotricité des enfants

Aurélien D'Ignazio, Juliette Martin

Nb. de pages: 224

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782353451838

Editeur: Tom Pousse

Date de parution: 2018

 

 

 

Electronic ebooks téléchargement gratuit 100 idées pour développer la psychomotricité des enfants in French 9782353451838 par Aurélien D'Ignazio, Juliette Martin FB2 PDF iBook

 

Overview

L'expérimentation du corps constitue chez l'enfant son référentiel de base pour coordonner ses gestes, s'orienter dans l'espace et le temps, réguler ses émotions, avoir confiance en soi... bref, tout le matériel cognitif et émotionnel nécessaire pour se sentir "bien dans son corps et dans sa tête" et profiter efficacement des apprentissages. En effet, maturation neurologique (pouvoir faire), développement cognitif (savoir faire) et épanouissement affectif (envie de faire) constituent les composantes indissociables du développement de l'enfant où tout progrès dans un domaine retentit sur les autres : motricité globale et tine, construction de la latéralité, organisation dans l'espace et dans temps. maîtrise du graphisme et de l'écriture, facultés de concentration, etc. De la difficulté mineure au trouble avéré (Dyspraxie, TAC, Dysgraphie, TDA/H...), nous exposons des contenus théoriques actualisés ainsi que les repères d'âges associés, afin de mieux comprendre les difficultés rencontrées par l'enfant. Comment les difficultés scolaires peuvent-elles trouver leurs origines dans des difficultés psychomotrices et comment tenter d'y remédier ? Comment mieux apprécier le développement psychomoteur de son enfant et décoder les éventuels signes d'alerte ? Quand s'orienter vers un professionnel spécialisé ? Loin d'avoir l'ambition de se substituer à une prise en charge en psychomotricité, les exercices, conseils et préconisations rassemblés dans cet ouvrage sauront néanmoins guider parents, enseignants et autres professionnels dans le développement psychomoteur de leur jeune public.
Peptic Ulcer and Bleeding Events Associated With Rofecoxib in a 3-Year Colorectal Adenoma Chemoprevention Trial
Creators: name: Lanas, Angel
name: Bresalier, Robert
name: Niv, Yaron
name: Baron, John A.
name: Loftus, Susan
name: Oxenius, Bettina
name: Schoen, Robert
name: Quan, Hui
name: Sandler, Robert S.
name: Cook, Tomas J.
name: Burke, Carol
name: Bolognese, Jim
name: Ridell, Robert
name: Watson, Douglas
name: Morton, Dion
name: Horgan, Kevin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND & AIMS: Our aim was to establish the incidence of symptomatic upper gastrointestinal ulcers, ulcer perforation, ulcer obstruction, or bleeding episodes (PUBs) associated with the use of selective cyclooxygenase-2 inhibitors at standard clinical doses compared with placebo. We report here on the PUB outcomes associated with the use of rofecoxib 25 mg in a 3-year, multicenter, double-blind, placebo-controlled trial designed to determine the effect of rofecoxib on the risk of recurrent neoplastic polyps of the colon.

METHODS: A total of 2587 patients with a history of colorectal adenomas underwent randomization to 25 mg/day of rofecoxib or to placebo. Investigator-reported PUBs were adjudicated by an external blinded committee. Kaplan-Meier and Cox proportional hazards techniques were used to estimate incidence and relative risks of PUBs in an intention-to-treat analysis.

RESULTS: Patients assigned to rofecoxib had a higher incidence of confirmed PUBs than those randomized to placebo (.88 vs .18 events per 100 patient-years; relative risk, 4.9; 95% confidence interval, 1.98-14.54). The incidence of confirmed complicated PUBs (ulcer perforation, obstruction, or bleeds) was low, but was numerically higher in the rofecoxib than in the placebo group (.23 vs .06 events per 100 patient-years; relative risk, 3.8; 95% confidence interval, .72-37.46; P = .14). Rofecoxib increased the incidence of confirmed PUBs vs placebo in both low-dose aspirin users and nonusers.

CONCLUSIONS: Among patients with a history of colorectal adenomas, the long-term use of 25 mg/day of rofecoxib was associated with an increased risk of clinically relevant upper gastrointestinal events when compared with placebo.
DOWNLOADS Le monde en 2050
Creators: name: Allen
Publisher: name: Zenodo
Year: 2024

description: Le monde en 2050 pan Marc Halévy

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Le monde en 2050

Marc Halévy

Nb. de pages: 95

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782492692079

Editeur: Laurence Massaro

Date de parution: 2022

 

 

 

Livres Kindle best seller téléchargement gratuit Le monde en 2050 (French Edition) par Marc Halévy 9782492692079 ePub

 

Overview

La prospective est un métier à part qui n'est ni de la divination ni de la prophétie ; elle s'appuie sur la modélisation des processus complexes et le monde humain en est un, comme la biosphère ou l'atmosphère terrestre. Nous traversons une zone chaotique majeure (dérèglement climatique, dérégulation océanique, pandémies, guerre en Ukraine, dislocation des Etats-Unis, délitement des démocraties, euroscepticisme, montée d'idéologies nauséabondes...). Ce chaos entérine l'effondrement de la Modernité, née à la Renaissance, et enclenche l'émergence d'un tout autre paradigme qui sera en place vers 2050 et qui touchera non seulement les grandes structures du monde, mais aussi toutes les dimensions de nos vies quotidiennes. Ce sont ces deux aspects complémentaires qu'étudie cet ouvrage
Figure S4 from Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference.
Creators: name: Jacquot, Maude
name: Nomikou, Kyriaki
name: Palmarini, Massimo
name: Mertens, Peter
name: Biek, Roman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes. Diffusion models using continuous space revealed that terrestrial habitat below 300 m altitude, wind direction and higher livestock densities were associated with faster BTV movement. Results of discrete phylogeographic analysis involving generalized linear models broadly supported these findings, but varied considerably with the level of spatial partitioning. Contrary to common perception, we found no evidence for average temperature having a positive effect on BTV diffusion, though both methodological and biological reasons could be responsible for this result. Our study provides important insights into the drivers of BTV transmission at the landscape scale that could inform predictive models of viral spread and have implications for designing control strategies.
In-situ measurements of void fractions and bubble size distributions in bubble curtains
Creators: name: Beelen, Simon
name: van Rijsbergen, Martijn
name: Birvalski, Miloš
name: Bloemhof, Fedde
name: Krug, Dominik
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We report the development of a novel measurement system designed to measure bubble properties in bubble curtains (i.e. planar bubble plumes) in-situ alongside acoustical measurements. Our approach is based on electrical, contact-based needle sensors in combination with an optical system. The latter is used for calibration and validation purposes. Correcting for the insensitive distance of the needle tips yields very good agreement between the two approaches in terms of the local void fraction and bubble size distributions. Finally, the system is employed to study bubble plumes evolving from three different hose types. All hoses display consistent self-similar behaviour with spreading rates increasing with increasing gas flow. The spreading is further found to be significantly higher when the bubble plumes originated from a porous hose compared to the two other hose types featuring either discrete holes or nozzle elements.
The 5:1 Neptune Resonance as Probed by CFEPS: Dynamics and Population
Creators: name: Pike, R. E.
name: Kavelaars, J. J.
name: Petit, J. M.
name: Gladman, B. J.
name: Alexandersen, M.
name: Volk, K.
name: Shankman, C. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Canada-France Ecliptic Plane Survey discovered four trans-Neptunian objects with semi-major axes near the 5:1 resonance, revealing a large and previously undetected intrinsic population. Three of these objects are currently resonant with Neptune, and the fourth is consistent with being an object that escaped the resonance at some point in the past. The non-resonant object may be representative of a detached population that is stable at slightly lower semi-major axes than the 5:1 resonance. We generated clones of these objects by resampling the astrometric uncertainty and examined their behavior over a 4.5 Gyr numerical simulation. The majority of the clones of the three resonant objects (>90%) spend a total of 10^7 years in resonance during their 4.5 Gyr integrations; most clones experience multiple periods of resonance capture. Our dynamical integrations reveal an exchange between the 5:1 resonance, the scattering objects, and other large semi-major axis resonances, especially the 4:1, 6:1, and 7:1. The multiple capture events and relatively short resonance lifetimes after capture suggest that these objects are captured scattering objects that stick in the 5:1 resonance. These 5:1 resonators may be representative of a temporary population, requiring regular contributions from a source population. We examined the dynamical characteristics (inclination, eccentricity, resonant island, libration amplitude) of the detected objects and their clones in order to provide an empirical model of the orbit structure of the 5:1 resonance. This resonance is dynamically hot and includes primarily symmetric librators. Given our orbit model, the intrinsic population necessary for the detection of these three objects in the 5:1 resonance is 1900(+3300 -1400, 95% confidence) with H_g< 8 and e > 0.5.
Read [Pdf]> Red Sky Mourning by Jack Carr
Creators: name: Brown
Publisher: name: Zenodo
Year: 2024

description: Red Sky Mourning by Jack Carr

 

 

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Red Sky Mourning

Jack Carr

Page: 448

Format: pdf, ePub, mobi, fb2

ISBN: 9781668069615

Publisher: Atria/Emily Bestler Books

 

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PACK COMO HACER QUE TE PASEN COSAS BUENAS leer epub MARIAN ROJAS
Creators: name: Kaplan
Publisher: name: Zenodo
Year: 2024

description: PACK COMO HACER QUE TE PASEN COSAS BUENAS de MARIAN ROJAS

Descargar eBook gratis ➡ Link

Ficha técnica

PACK COMO HACER QUE TE PASEN COSAS BUENAS

MARIAN ROJAS

Número de páginas: 248

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788467057669

Editorial: S.L.U. ESPASA LIBROS

Año de edición: 2019

 

 

 

 

 

Leer libros en línea descargar gratis PACK COMO HACER QUE TE PASEN COSAS BUENAS 9788467057669 in Spanish de MARIAN ROJAS FB2 MOBI

 

Overview

Disfruta el presente, supera el pasado y mira con ilusión el futuro.

¿Sabes que tus emociones y tus pensamientos tienen un impacto directo en tu organismo, en tu percepción de la realidad e incluso en tus propios genes?¿Eres consciente de que tu manera de gestionar los conflictos te puede predisponer a sufrir ansiedad o depresión, las enfermedades más frecuentes del siglo XXI?Para la doctoraMarian Rojas Estapé la felicidad consiste en vivir instalado de forma sana en el presente, habiendo superado las heridas del pasado y mirando con ilusión al futuro. Muchos de los trastornos que padecemos provienen de la incapacidad para gestionar nuestro presente. La felicidad no es lo que nos pasa, sino cómo interpretamos lo que nos pasa.EnCómo hacer que te pasen cosas buenas entenderás la importancia de aprender a enfocar tu atención y descubrirás pautas para combatir los miedos, las angustias y cómo canalizar las emociones negativas que te llegan a bloquear física y mentalmente.
The Attrition of Young Physician-Scientists: Problems and Potential Solutions
Creators: name: Donowitz, Mark
name: Germino, Greg
name: Anderson, James M.
name: Cominelli, Fabio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Physician-scientists have played a prominent role as thought leaders in American medicine over the past century. This group has produced many basic scientific advances and pioneered the translation of these advances into clinical practice. Now that we are in the post-genomic era, there is a greater need than ever for the continued participation of this group because of their unique ability to bridge the "bench to bedside." However, the number of physicians pursuing this career is static and their average age is rising. Recent data indicate that the many benefits of this career path are seen as being outweighed by so many negative factors, as to prompt the question, "Is this a career that a reasonable person should undertake in 2007 and beyond?" The following analysis suggests that the current answer is "no." We have identified the lack of professional security as a major factor that prompts young physicians to abandon the physician-scientist track. Because this problem has not been sufficiently emphasized, we believe current efforts are unlikely to reverse this disturbing trend. We propose strategies that seek to address this problem and help sustain young physician-scientists at career transition points at which they are most vulnerable to give up.
Simulation of the Solar Energetic Particle Event on 2020 May 29 Observed by Parker Solar Probe
Creators: name: Cheng, Lei
name: Zhang, Ming
name: Lario, David
name: Balmaceda, Laura A.
name: Kwon, Ryun Young
name: Cohen, Christina
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: This paper presents a stochastic three-dimensional (3D) focused transport simulation of solar energetic particles (SEPs) produced by a data-driven coronal mass ejection (CME) shock propagating through a data-driven model of coronal and heliospheric magnetic fields. The injection of SEPs at the CME shock is treated using diffusive shock acceleration of post-shock superthermal solar wind ions. A time backward stochastic simulation is employed to solve the transport equation to obtain the SEP time-intensity profile at any location, energy, and pitch angle. The model is applied to a SEP event on 2020 May 29, observed by STEREO-A close to 1 au and by Parker Solar Probe (PSP) when it was about 0.33 au away from the Sun. The SEP event was associated with a very slow CME with a plane-of-sky speed of 337 km/s at a height below 6 $\rm R_S$ as reported in the SOHO/LASCO CME catalog. We compute the time profiles of particle flux at PSP and STEREO-A locations, and estimate both the spectral index of the proton energy spectrum for energies between 2 and 16 MeV and the equivalent path length of the magnetic field lines experienced by the first arriving SEPs. We found that the simulation results are well correlated with observations. The SEP event could be explained by the acceleration of particles by a weak CME shock in the low solar corona that is not magnetically connected to the observers.
description: 18 pages, 6 figures
Near Infrared High Resolution Spectroscopy and Spectro-astrometry of Gas in Disks around Herbig Ae/Be Stars
Creators: name: Brittain, Sean D.
name: Najita, Joan R.
name: Carr, John S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In this review, we describe how high resolution near infrared spectroscopy and spectro-astrometry have been used to study the disks around Herbig~Ae/Be stars. We show how these tools can be used to identify signposts of planet formation and elucidate the mechanism by which Herbig Ae/Be stars accrete. We also highlight some of the artifacts that can complicate the interpretation of spectro-astrometric measurements and discuss best practices for mitigating these effects. We conclude with a brief discussion of the value of long term monitoring of these systems.
description: to be published in Astrophysics and Space Science
Figure S2 from Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference
Creators: name: Jacquot, Maude
name: Nomikou, Kyriaki
name: Palmarini, Massimo
name: Mertens, Peter
name: Biek, Roman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes. Diffusion models using continuous space revealed that terrestrial habitat below 300 m altitude, wind direction and higher livestock densities were associated with faster BTV movement. Results of discrete phylogeographic analysis involving generalized linear models broadly supported these findings, but varied considerably with the level of spatial partitioning. Contrary to common perception, we found no evidence for average temperature having a positive effect on BTV diffusion, though both methodological and biological reasons could be responsible for this result. Our study provides important insights into the drivers of BTV transmission at the landscape scale that could inform predictive models of viral spread and have implications for designing control strategies.
The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer
Creators: name: Inoue, Toru
name: Compton, Carolyn
name: Hamilton, Cody
name: Arnold, Christian N.
name: Mayer, Robert J.
name: Goldberg, Richard
name: Nagasaka, Takeshi
name: Bertagnolli, Monica M.
name: Niedzwiecki, Donna
name: Goel, Ajay
name: Boland, C. Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND & AIMS: The CpG island methylator phenotype (CIMP) is one of the mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the cause of high-frequency microsatellite instability (MSI-H) sporadic CRCs, its role in microsatellite stable (MSS) tumors is debated. The majority of MSS CRCs demonstrate chromosomal instability (CIN) with frequent loss of heterozygosity (LOH) at key tumor suppressor genes. We hypothesized that the majority of sporadic CRCs without CIN would be associated with CIMP.

METHODS: We tested 126 sporadic CRCs for MSI and LOH and categorized tumors into MSI, LOH, or MSI-/LOH- subgroups. Methylation status was evaluated using 6 CIMP-related markers (MINT1, MINT2, MINT31, p16(INK4alpha), p14(ARF), and hMLH1) and 6 tumor suppressor genes (PTEN, TIMP3, RUNX3, HIC1, APC, and RARbeta2). BRAF V600E mutation analysis was performed using allele-specific polymerase chain reaction and DNA sequencing.

RESULTS: We observed frequent methylation at all 12 loci in all CRCs. BRAF V600E mutations correlated with the MSI (P < .0001) and MSI-/LOH- (P = .03) subgroups. MSI and MSI-/LOH- tumors exhibited more promoter methylation than CRCs with LOH (P < .0001). We also found an inverse correlation between the frequencies of methylation and LOH (rho = -0.36; P < .0001).

CONCLUSIONS: The associations between methylation frequencies at CIMP-related markers and MSI or MSI-/LOH- sporadic CRCs suggest that the majority of these tumors evolve through CIMP. These findings suggest that CIN and CIMP represent 2 independent and inversely related mechanisms of genetic and epigenetic instability in sporadic CRCs and confirm that MSI cancers arise as a consequence of CIMP.
Effect of Abuse History on Pain Reports and Brain Responses to Aversive Visceral Stimulation: An fMRI Study
Creators: name: Ringel, Yehuda
name: Lin, Weili
name: Naliboff, Bruce D.
name: Whitehead, William E.
name: Drossman, Douglas A.
name: Leserman, Jane L.
name: Mayer, Emeran A.
name: Berman, Steven
name: Wilber, Kathy
name: Suyenobu, Brandall Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Abuse history is common in irritable bowel syndrome (IBS) and is associated with greater pain reporting, psychologic distress, and poorer health outcome. These effects may be mediated by enhanced responses to aversive visceral stimuli. We investigated the effects of IBS and abuse history on pain reporting and brain activation in response to rectal distentions. Ten female patients with IBS and 10 controls were included. Half of patients in each group reported a history of abuse. Brain functional magnetic resonance imaging (fMRI) images and pain ratings were obtained during rectal distentions. Statistical parametric mapping identified activation in subregions of the dorsal cingulate cortex and covariation with rated pain. (1) Distention-elicited pain correlated with anxiety and activation of the posterior (PCC) and middle (MCC) dorsal cingulate subregions. (2) Subjects with a history of abuse showed greater activation in the left MCC ( = .022; t = 5.61) and PCC ( = .033; t = 5.00) than subjects without abuse. (3) Those with IBS and abuse reported greater pain than all others ( = .004), had more activity in the left MCC ( = .021; t = 5.29) and PCC ( = .049; t = 4.81), and had less activity in the left supragenual anterior cingulate (sACC) ( = .01; t = 4.86). Pain ratings during rectal distention are associated with activation of dorsal cingulate regions implicated in homeostatic afferent processing, and prior abuse enhances this activation. Patients with IBS and abuse report more pain, greater MCC/PCC activation, and reduced activity of a region implicated in pain inhibition and arousal (sACC). These findings suggest a possible explanation for the clinical observation of greater pain reporting and poorer outcome in IBS patients with a history of abuse.
Figure S3 from Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference.
Creators: name: Jacquot, Maude
name: Nomikou, Kyriaki
name: Palmarini, Massimo
name: Mertens, Peter
name: Biek, Roman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes. Diffusion models using continuous space revealed that terrestrial habitat below 300 m altitude, wind direction and higher livestock densities were associated with faster BTV movement. Results of discrete phylogeographic analysis involving generalized linear models broadly supported these findings, but varied considerably with the level of spatial partitioning. Contrary to common perception, we found no evidence for average temperature having a positive effect on BTV diffusion, though both methodological and biological reasons could be responsible for this result. Our study provides important insights into the drivers of BTV transmission at the landscape scale that could inform predictive models of viral spread and have implications for designing control strategies.