title: Ð¡ÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐµÑÑÐ°Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° Ac-RÐRR-NH2 Ð½Ð° Ð¸Ð½Ð´ÐµÐºÑ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ ÑÐ¾ÑÑÐ° Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð¸ ÑÐºÐ°Ð½Ð¸ ÑÐµÑÐ´ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Comparative study of the effect of tetrapeptide Ac-RR-NH2 on the growth area index of nervous tissue and heart tissue
Creators: name: ÐÐ°ÑÐ¸Ð»ÑÐµÐ²Ð°, Ð¡Ð²ÐµÑÐ»Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¾ÑÐ³Ð°Ð½Ð¾ÑÐ¸Ð¿Ð¸ÑÐµÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ° ÑÐºÐ°Ð½Ð¸
ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ðµ Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ
ÑÐµÐ½ÑÐ¾ÑÐ½ÑÐµ Ð³Ð°Ð½Ð³Ð»Ð¸Ð¸
ÑÐºÑÐ¿Ð»Ð°Ð½ÑÐ°ÑÑ ÑÐºÐ°Ð½Ð¸ ÑÐµÑÐ´ÑÐ°
organotypic tissue culture
short peptides
sensory ganglia
heart tissue explants

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description: The subject of the graduate qualification work: "Comparative study of the effect of tetrapeptide Ac-RR-NH2Â on the growth area index of nervous tissue and heart tissue". This work is devoted to the quantitative study of the effect of tetrapeptide Ac-RR-NH2Â in different concentrations on the index of the growth area of nervous tissue and heart tissue. Tasks that were set and solved during the study: 1. To investigate the effect of tetrapeptide Ac-RR-NH2Â on the growth of neurites in the organotypic culture of spinal ganglia. 2. To evaluate the effect of tetrapeptide on the growth of neurites of spinal ganglia neurons. 3. To evaluate the effect of tetrapeptide Ac-RR-NH2Â on the growth of heart tissue explants using the method of organotypic tissue culture. The work was carried out on the basis of the Laboratory of Physiology of excitable membranes and the equipment of the Confocal Microscopy Center of the I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences. In the course of the work, studies were carried out using the method of organotypic tissue culture. The objects were explants of spinal ganglia and heart tissue of 10-12-day-old chicken embryos. The work was aimed at investigating the effect of comparing the growth area index of tissue culture with the introduction of tetrapeptide tetrapeptide on the growth of the studied tissues.A pronounced neurite-stimulating effect was observed when tetrapeptide Ac-RR-NH2Â was added to the culture medium at a concentration of 10^-10Â Mol/l, which manifested itself in a significant stimulation of neurite growth of spinal ganglia neurons. The introduction of this agent into the nutrient medium did not affect the growth of heart explants. This result indicates that this tetrapeptide has no specific effect on the membrane of cardiomyocytes. The results obtained indicate that the agent under study does not have a specific effect on other tissues.