cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Experience of Voices in Borderline Personality Disorder
Creators: name: Merrett, Zalie
Publisher: name: Swinburne
Year: 2024

description: This thesis comprehensively explored multisensory hallucinations (e.g., verbal, visual, olfactory, tactile) and delusions in Borderline Personality Disorder (BPD), and compared those experiences to schizophrenia spectrum disorder. It aimed to better understand the phenomenology of these psychotic experiences.
It also explored the aetiological foundations of auditory verbal hallucination (AVH) proneness in BPD by investigating childhood trauma, anxiety, depression and dissociation as plausible mechanisms.
The findings support assertions that people with BPD experience significant hallucinations and delusions, and uniquely provide an important step in understanding the aetiology of AVH in BPD.
Toward Portable GPU Performance: Julia Recursive Implementation of TRMM and TRSM
Creators: name: Carrica, Vicki
name: Onyango, Maxwell
name: Alomairy, Rabab
name: Ringoot, Evelyne
name: Schloss, James
name: Edelman, Alan
Publisher: name: Zenodo
Year: 2025

description: This paper presents a performant and portable recursive implementation of triangular matrix-matrix multiplication (TRMM) and triangular solve (TRSM) operations in Julia for GPUs, which form the backbone of many other linear algebra algorithms. This work is based on an existing recursive implementation for TRMM and TRSM, which restructures the operations to include general matrix-matrix multiplication (GEMM) calls, facilitating better utilization of the GPU memory hierarchy, and reducing latency overhead. The unified implementation in Julia harnesses the language’s multiple-dispatch and metaprogramming capabilities through the existing GPUArrays and KernelAbstractions frameworks, enabling performant hardware-agnostic execution across different GPU architectures. By supporting a consistent API, this implementation allows users to seamlessly switch between different GPU backends. The recursive hardware-agnostic implementation we present achieves performance comparable to vendor-optimized (cuBLAS/rocBLAS) libraries for larger matrix sizes and provides such methods for the first time to Apple Silicion hardware with only a few hundred lines of code, demonstrating the power of unified implementations.
Stirring the Pot : Navigating Work Life Balance as a Home Economics Educator
Creators: name: Hawken, Nicola Margaret
Publisher: name: The University of British Columbia
Year: 2025

description: Home Economics (HE) educators face distinct challenges in achieving work-life balance due to the hands-on and personal nature of their subject. Beyond lesson planning and instruction, HE teachers manage additional responsibilities such as purchasing materials, organizing food labs, and overseeing school-wide events, often extending their workload beyond contractual hours. These blurred boundaries between professional and personal life contribute to burnout, emotional exhaustion, and demoralization. This study employs autobiographical inquiry and self-study to examine my lived experiences as an HE educator navigating work-life balance. Through reflective journaling and analysis of teaching artifacts, I explore the emotional labor, workload expectations, and institutional pressures unique to HE education. Thematic analysis revealed five key challenges: (1) the intrusion of work into personal time, (2) the emotional toll of teaching a personal subject, (3) expectations of additional responsibilities, (4) time management and boundary-setting, and (5) the role of support networks. Findings highlight the need for institutional recognition of HE educators’ workloads, clearer policies on assignable hours, and strategies for sustainable teaching practices. This study contributes to discussions on teacher well-being and professional sustainability, advocating for systemic changes that support educators in balancing their professional and personal lives.
Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
Creators: name: Schillemans, Tessa
name: Kolossa-Gehring, Marike
name: Iszatt, Nina
name: Remy, Sylvie
name: Vogel, Nina
Publisher: name: My University
Year: 2023
Subjects: Biomonitoring
Exposition
Perfluoroctansulfonsäure
Perfluoroktansäure
Polychlorierte Biphenyle
Bundesrepublik Deutschland
Europa

description: Per- and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU) initiative. We used data from 1957 teenagers (12-18 yrs) that were part of the HBM4EU aligned studies, consisting of nine HBM studies (NEBII, Norway; Riksmaten Adolescents 2016-17, Sweden; PCB cohort (follow-up), Slovakia; SLO CRP, Slovenia; CROME, Greece; BEA, Spain; ESTEBAN, France; FLEHS IV, Belgium; GerES V-sub, Germany). Twelve PFAS were measured in blood, whilst weight and height were measured by field nurse/physician or self-reported in questionnaires. We assessed associations between PFAS and age- and sex-adjusted BMI z-scores using linear and logistic regression adjusted for potential confounders. Random-effects meta-analysis and mixed effects models were used to pool studies. We assessed mixture effects using molar sums of exposure biomarkers with toxicological/structural similarities and quantile g-computation. In all studies, the highest concentrations of PFAS were PFOS (medians ranging from 1.34 to 2.79 mikro/L). There was a tendency for negative associations with BMI z-scores for all PFAS (except for PFHxS and PFHpS), which was borderline significant for the molar sum of [PFOA and PFNA] and significant for single PFOA [beta-coefficient (95% CI) per interquartile range fold change = -0.06 (-0.17, 0.00) and -0.08 (-0.15, -0.01), respectively]. Mixture assessment indicated similar negative associations of the total mixture of [PFOA, PFNA, PFHxS and PFOS] with BMI z-score, but not all compounds showed associations in the same direction: whilst [PFOA, PFNA and PFOS] were negatively associated, [PFHxS] associated positively with BMI z-score. Our results indicated a tendency for associations of relatively low PFAS concentrations with lower BMI in European teenagers. More prospective research is needed to investigate this potential relationship and its implications for health later in life. © 2022 The Authors
Linfoma de Hodgkin: do diagnóstico ao tratamento
Creators: name: Letícia Christiany Rodrigues Catharino Rafaella Valadares Diniz Laura Carolina Daroszewski Nogueira Guilherme Machado Moura Jéssica Thalita Alkmin Ferreira Sara Wagner Ribeiro Gontijo Rafael Cota Andrade Ferreira de Souza Isabele Borges Bueno Carolina Felipe Cotta
Publisher: name: Zenodo
Year: 2024

description: O Linfoma de Hodgkin (LH) é um tipo raro de câncer do sistema linfático, caracterizado pela presença das células de Reed-Sternberg. O diagnóstico precoce é crucial para melhorar o prognóstico, sendo baseado em achados clínicos, histopatológicos e de imagem. O tratamento do LH evoluiu significativamente, incorporando quimioterapia, radioterapia e, em casos específicos, transplante de células-tronco. Este artigo revisa o diagnóstico, tratamento e prognóstico do LH, destacando avanços recentes e desafios na gestão da doença. Conclui-se que, apesar dos progressos, o LH continua a exigir um acompanhamento multidisciplinar para garantir a máxima eficácia terapêutica e minimizar complicações a longo prazo.
Clearing the air: Expression of nitrous oxide reductase from Pseudomonas stutzeri in transgenic tobacco
Creators: name: Staebler, Julianne Marie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Chemistry, Biochemistry.

description: As atmospheric concentrations of N2O, a potent greenhouse gas and destructor of ozone, continue to increase, it is important to explore a range of solutions for this issue. The bacterial enzyme responsible for catalyzing the final step of the denitrification pathway, conversion of N 2O to N2, is nitrous oxide reductase (N2OR). It is the aim of this study to produce model tobacco plants expressing the nitrous oxide reductase gene (nosZ) with the ultimate goal of supplying additional N2OR to the plant-microbial-soil environment for more efficient reduction of N2O and mitigation of agricultural N 2O emissions. Two nitrous oxide reductase expression cassettes under the control of (1) the d35S constitutive promoter and, (2) the rolD root-specific promoter were constructed and used to transform Nicotiana tabacum tissue. Integration and expression of the nosZ transgene in T0 and T1 generation plants was demonstrated by PCR and RT-PCR. Production of recombinant N2OR in T0 plants was shown by western immunoblot.
Semaglutide para insuficiência cardíaca: há fundamento?
Creators: name: Letícia Christiany Rodrigues Catharino Rafaella Valadares Diniz Laura Carolina Daroszewski Nogueira Guilherme Machado Moura Jéssica Thalita Alkmin Ferreira Sara Wagner Ribeiro Gontijo Rafael Cota Andrade Ferreira de Souza Isabele Borges Bueno Carolina Felipe Cotta
Publisher: name: Zenodo
Year: 2024

description: O semaglutide, um análogo do GLP-1, tem mostrado benefícios significativos em pacientes com diabetes tipo 2, mas sua eficácia na insuficiência cardíaca (IC) ainda está sendo investigada. Este artigo explora a evidência atual sobre o uso de semaglutide no tratamento de IC, abordando seus efeitos sobre a função cardíaca e os desfechos clínicos. A revisão inclui ensaios clínicos recentes e dados observacionais para avaliar se semaglutide pode oferecer um tratamento adicional para IC. Conclui-se que, enquanto os resultados preliminares são promissores, mais estudos são necessários para estabelecer seu papel definitivo no manejo da insuficiência cardíaca.
Relationships between composition and size distribution of invertebrates colonizing navigation buoys and physico-chemical parameters of the St. Lawrence River, Montreal (Quebec).
Creators: name: Mercier, Vincent.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Ecology.

description: Water, algae and invertebrates colonizing navigational buoys at 18 sites in the Montreal area of the St. Lawrence River were sampled during the spring, summer and fall of 1995 to assess which measures of invertebrate assemblages (density, biomass, size distribution, and taxonomic composition) best respond to wastewater discharge and to compare invertebrate responses among sampling dates. Increases of up to five orders of magnitude in fecal coliforms, 2-fold increases in TP and PO$\sb4,$ 20-fold increases in NH$\sb4$ concentration and 2-3-fold decreases in water clarity (Secchi depth, suspended matter) were found downstream of point sources of urban wastewater discharge. Despite these physico-chemical changes, invertebrate assemblages were only weakly related to wastewater exposure, since DFA on composition and size distribution only correctly classified 44-61% of sites into groups based on fecal coliform concentration for all four sampling dates. Fecal coliforms were best predicted by Chironomidae, other Diptera and Nematoda density in the fall (mult. reg. adj.r$\sp2$ = 0.69, p $$ 0.001), density of invertebrates in the size class 4-8 $\mu$g in the fall (adj.r$\sp2$ = 0.65, p $$ 0.001), and total invertebrate density (adj.r$\sp2$ = 0.75, p = 0.002) in the spring. Periphyton biomass, suspended matter concentration and current velocity were the main environmental correlates of invertebrate composition and size distribution patterns in the fall. In the second chapter, spatio-temporal patterns of buoy invertebrate and algal size distributions were investigated, in relation to trophic gradients in the river. The size distributions were not significantly related to physico-chemical parameters of the river, although variability in the data may have been too high to detect trophic effects. Size spectra on buoys, despite the fact that protozoans were not accounted for, had striking similarities with other complete size distributions (containing algae, protozoans and invertebrates) from stream, lake and marine littoral zones. (Abstract shortened by UMI.)
The arrangement of information in the general bilingual dictionary entry.
Creators: name: Van Scherrenburg, Daniel.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Library Science.

description: One topic that has not been dealt with extensively in the literature on bilingual lexicography and in the front matter of general bilingual dictionaries (GBDs) is the arrangement of information within the GBD entry. Thus, I have endeavoured to present in one work various arrangement techniques for seven important GBD entry elements: the equivalent, the meaning, the context, the meaning discrimination device, the example, the idiom and the compound. It is hoped that by providing a clear description of possible arrangement techniques for these elements, this thesis will not only provide lexicographers with further insight into bilingual dictionary methodology, but also help dictionary-users to better appreciate some of the problems faced by bilingual lexicographers.
D'un modèle pour la formation de pores alignés de peptides dans une bi-couche lipidique sous une rampe de tension
Creators: name: Boucher, Pierre-Alexandre
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Physics, General.

description: Un modèle en réseau pour la formation de pores alignés de peptides dans une bi-couche lipidique est construit à partir du modèle établi par Fournier et Joos. Ce modèle est tout d'abord étendu pour supporter des rampes de tension. Nous reproduisons les résultats obtenus par Evans et al. Lorsque le taux d'application de la tension sur une membrane est augmenté, la tension à laquelle elle se brise augmente et la densité de probabilité de rupture s'élargit. Notre modèle prédit aussi qu'avec une augmentation de la concentration de peptides, la tension à la rupture diminue et la largeur de la distribution de tension à la rupture augmente. Il prédit aussi qu'a tension zéro, une certaine concentration de peptides causera la formation de pores peptides et ainsi la perte de contenu vesiculaire. La demi-vie du processus de perte de contenu dépend linéairement du module de compressibilité et de la longueur des chaînes hydrophobes. Nous montrons que la tension de rupture d'une membrane contient une composante qui varie avec l'inverse du nombre de lipides composant la membrane.
L'Épuisement professionnel chez les animatrices et agentes de pastorale oeuvrant dans l'église du Québec: Exploration et compréhension du phénomène
Creators: name: Deshaies Roy, Jeanine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Religion, General.
subject: Women's Studies.

description: Cette étude met en relief la problématique de l'épuisement professionnel relevée à partir de quatre femmes oeuvrant en milieu ecclésial québécois. L'exploration des quatre histoires de cas dans le temps soulève les particularités ci-après. Dans la période qui précède l'épuisement, en plus d'offrir les mêmes lieux de désappairage ou "mismatch" propices au développement du burnout, l'Église du Québec produit chez ces quatre femmes une structure de désengagement progressif directement liée au burnout. Dans la période de l'épuisement, nous avons trouvé un mouvement de déstabilisation interne suivi d'un cycle de reconstruction de la personne par lequel les quatre animatrices de pastorale sont parvenues à retrouver l'unité organique interne et le sens de l'engagement qui les habitaient avant l'épuisement. Dans la période après l'épuisement, les quatre animatrices de pastorales étaient en mesure de diriger et d'orienter leurs choix de vie et de carrière dans le sens leur mission personnelle et de leur accomplissement personnel. Suite à cette exploration, un schéma représentatif du burnout a été établi. Il représente la structure interne de la personne avant, pendant et après l'épuisement professionnel. Il serait intéressant de pousser plus loin les recherche dans le domaine du burnout et de vérifier si le schéma représentatif du burnout se présente chez un plus grand nombre de personnes et deprofessions.
La démocratie entre l'universel et le particulier : essai sur le statut de l'idéal démocratique : une perspective kantienne.
Creators: name: Kaboré, Boniface.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Philosophy.

description: La conscience democratique contemporaine est heritiere de deux traditions de pensee antagonistes qui sont, d'un cote, l'universalisme des Lumieres symbolise par la Declaration universelle des droits de l'homme et du citoyen, et de l'autre le relativisme historique legue par l'Ecole historique du droit et les courants de pensee historicistes. Il tient en deux positions de principe: l'affirmation peremptoire, d'une part, de l'universalite des ideaux de la democratie et des droits de l'homme; la legitimation, d'autre part, des particularismes identitaires et socio-culturels comme source constitutives de valeurs. D'ou precisement l'antagonisme entre vision universaliste et vision relativiste sur le statut axiologique de l'ideal democratique. C'est a cette question, redefinie a l'interieur du paradigme de la philosophie morale de Kant, que nous avons tente d'apporter une solution theorique qui fait droit aussi bien a la pretention universaliste de la norme democratique qu'a la "verite" de la conscience historique. L'ideal democratique ou l'Idee republicaine, s'il peut etre considere comme l'analogue politique de l'imperatif categorique, c'est d'abord parce qu'il peut etre pense, au titre de principe de l'ordre politique juste absolument, comme forme a priori de la raison, bien qu'il soit apparu dans une periode historique determinee et dans une ere culturelle particuliere, c'est-a-dire en Europe au XVIII$\rm\sp{e}$ siecle s'agissant specifiquement de l'ideal moderne de la democratie. Cette interpretation kantienne du statut de l'ideal democratique nous amene a prendre partie pour un universalisme formel, qui s'articule autour du lien etroit et necessaire devant prevaloir entre l'universel et le particulier. C'est ce lien que nie, en meme temps qu'elle le rompt, la rivalite traditionnelle entre l'universalisme dogmatique et le relativisme sans reserve. Aussi bien, contre le premier, l'universalisme formel inscrit l'universel dans la forme a priori de la raison comme en son lieu axiologique propre, jamais dans un contenu reel ou historique. Au second, il oppose l'horizon du formalisme kantien comme celui du discours universaliste, l'horizon qui rend possible et legitime la reference a l'universel democratique. C'est a cette condition qu'il nous parai t possible de justifier a la fois l'idee d'un imperatif categorique democratique et l'historicite essentielle des "experiences de l'universel" nourries par les singularismes socio-culturels et historiques. Ainsi, sommes-nous parvenu a esquisser les grandes lignes d'une interpretation kantienne du statut de l'ideal democratique, une interpretation universaliste-formaliste qui tient tete autant au dogmatisme moral qu'au relativisme sans bornes. (Abstract shortened by UMI.)
Effect of grammaticality judgements on the relationship between metalinguistic awareness and second language proficiency.
Creators: name: Renou, Janet M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Education, Language and Literature.

description: This study investigated the relationship between metalinguistic awareness (MLA) and L2 proficiency of second language learners from an experiential (communicative) and an analytic (grammar) approach to learning French. The model tested (Bialystok & Ryan, 1985) posits that linguistic and metalinguistic proficiency are composed of two components--'analysed knowledge' and 'control' over that knowledge. All tasks (e.g., conversation, literacy, metalinguistic) require some degree of both components. Since the development of the components is the result of different learning experiences, learners may master aspects of proficiency related to an increase in analysed knowledge but not master ones which stem from an increase in control, or vice versa. This is problematic in that it is conceivable that learners may have a very different mastery of the language when task demands change. Advanced university level French L2 learners (n = 64) completed a French Test of Proficiency and a written and oral grammaticality judgement test. The grammaticality judgement task required subjects to judge sentences for grammaticality, to identify errors, to correct errors and to provide the rule which had been violated. The first level of analysis looked at the performance of the entire sample on the grammaticality judgement tests and on the test of L2 proficiency. Then further analyses were carried out in light of the demands tasks made upon the two components and with subjects grouped according to learning methods; that is whether they had been exposed to a communicative or grammar approach to L2 learning. Results show that there is a positive relationship between MLA and L2 proficiency when analyses are run for the entire sample, but that once learners are grouped according to learning methods, that positive relationship no longer exists for communicative-approach learners. Tasks which made similar demands did not always correlate. Significant differences were found in learners' performance depending upon whether the tasks required high levels of analysed knowledge, control, or both and depending upon the type of learning method. Implications for the model and for L2 learning conclude the study.
The application of modified agile methodology to the development of integrated business solutions
Creators: name: McLellan, Jamie
Publisher: name: Swinburne
Year: 2024

description: This study aimed to determine if Scrum (a project management methodology that emphasises teamwork, accountability, and an iterative progress toward a well-defined goal) could be used as an integrated business solution development methodology for a medical device manufacturer in the Australian medical technology context and if so, determine what aspects of Scrum are most applicable. Despite contributions from various research streams to the literature over the past 20 years, there remain significant gaps for contemporary servitisation researchers in providing managers and practitioners guidance in co-developing integrated business solution offerings with critical customers. The intended audience is practitioner and academic with contributions to the integrated business solutions development literature and a potential model for practitioners to implement for manufacturers in the medical technology industry.
Modelisation de la courbe ROC a partir des distributions de Pearson
Creators: name: Cheam, Amay S.M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Mathematics.

description: The Receiver Operating Characteristic curve (ROC) is frequently used in medical studies to assess the efficiency of a diagnostic test. There exists two different ways to model the curve theoretically: direct and indirect. The direct method consists of constructing the curve based on the observed data. This method is less appealing in that the curve obtained is not easily interpretable. In the indirect method, a distribution is assumed for both the diseased and non-diseased patients. The normal distribution has been used to model both types of patients owing to the ease of its manipulation. In this thesis, we propose the use of the Pearsonian system of distributions in order to select the distribution for the diseased and non-diseased patients. An approach using a Monte Carlo simulation provides a confidence band for the derived ROC. The approach is evaluated using normal, gamma and beta distributed data. It is also tested on a real data set. It is seen that the Pearson based estimation of the ROC is at least as accurate as the normal theory based approach and often superior. Key words : ROC curve, Pearson distribution, AUC, pAUC, trapezoidal rule, Mann-Whitney U-Stat, Monte-Carlo simulation.
title: Valoración de pacientes con crisis epilépticas focales en RM 3-T
Creators: name: Sarria Estrada, Silvana  Isabel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neuroradiology brain
subject: MR
subject: Seizure disorders

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Evaluación de la neuroimagen en RM-3T para demostrar lesiones cerebrales en epilepsia focal (EF). Valorar las alteraciones de perfusión intercríticas asociado a lesiones epileptógenas por técnica de...
Measurements of small-scale statistics and probability density functions in passively heated shear flow.
Creators: name: Ferchichi, Mohsen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Mechanical.

description: This study is an experimental investigation consisting of two parts. In the first part, the fine structure of uniformly sheared turbulence was investigated within the framework of Kolmogorov's (1941) similarity hypotheses. The second part, consisted of the study of the scalar mixing in uniformly sheared turbulence with an imposed mean scalar gradient, with the emphasis on measurements relevant to the probability density function formulation and on scalar derivative statistics. The velocity fine structure was invoked from statistics of the streamwise and transverse derivatives of the streamwise velocity as well as velocity differences and structure functions, measured with hot wire anemometry for turbulence Reynolds numbers, Relambda, in the range between 140 and 660. The streamwise derivative skewness and flatness agreed with previously reported results in that they increased with increasing Relambda with the flatness increasing at a higher rate. The skewness of the transverse derivative decreased with increasing Relambda, and the flatness of this derivative increased with Relambda but a lower rate than the streamwise derivative flatness. The high order (up to sixth) transverse structure functions of the streamwise velocity showed the same trends as the corresponding streamwise structure functions. In the second pan of tins experimental study, an army of heated ribbons was introduced into the flow to produce a constant mean temperature gradient, such that the temperature acted as a passive scalar. The Re lambda in this study varied from 184 to 253. Cold wire thermometry and hot wire anemometry were used for simultaneous measurements of temperature and velocity. The scalar pdf was found to be nearly Gaussian. Various tests of joint statistics of the scalar and its rate of destruction revealed that the scalar dissipation rate was essentially independent of the scalar value. The measured joint statistics of the scalar and the velocity suggested that they were nearly jointly normal and that the normalized conditioned expectations varied linearly with the scalar with slopes corresponding to the scalar-velocity correlation coefficients. Finally, the measured streamwise and transverse scalar derivatives and differences revealed that the scalar fine structure was intermittent not only in the dissipative range, but in the inertial range as well.
title: Fracturas femorales relacionadas con los bifosfonatos
Creators: name: Ramos Gavila, Elisa
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Extremities
subject: Trauma
subject: Musculoskeletal bone

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Recientes estudios han informado un aumento de la prevalencia de fracturas femorales de baja energía en pacientes en tratamiento a largo plazo con bifosfonatos.
El objetivo de nuestro trabajo es describir las características de este tipo de...
Leucemia mieloide aguda: diagnóstico precoce e propedêuticas
Creators: name: Letícia Christiany Rodrigues Catharino Rafaella Valadares Diniz Laura Carolina Daroszewski Nogueira Guilherme Machado Moura Jéssica Thalita Alkmin Ferreira Sara Wagner Ribeiro Gontijo Rafael Cota Andrade Ferreira de Souza Isabele Borges Bueno Carolina Felipe Cotta
Publisher: name: Zenodo
Year: 2024

description: As valvopatias representam um conjunto de doenças que afetam as válvulas cardíacas, resultando em distúrbios funcionais que variam desde estenoses até insuficiências. A abordagem clínica dessas condições exige um diagnóstico rápido e preciso, seguido de um manejo terapêutico imediato para evitar complicações graves, como insuficiência cardíaca e morte súbita. Este artigo revisa as principais valvopatias, abordando a prática clínica, o diagnóstico, e as opções de manejo imediato, com ênfase na importância de uma intervenção precoce. A revisão integrativa é baseada em estudos recentes, enfatizando a necessidade de estratégias personalizadas que considerem a gravidade da doença e as condições clínicas de cada paciente.
Integrating Culturally Responsive Curriculum and Pedagogy in Home Economics Educaiton
Creators: name: Prosper, Kersil
Publisher: name: The University of British Columbia
Year: 2025

description: This paper explores the implementation of culturally responsive pedagogy in teaching Home Economics in a Caribbean school, where cultural traditions, and diverse family structures shape students' lived experiences. It examines the CSEC Home Economics syllabus and the Lower Secondary School Home Economics Curriculum in St. Lucia’s TVET system for evidence of culturally responsiveness. Using a qualitative approach, the researcher makes recommendations for how Home Economics educators can incorporate local knowledge, indigenous practices, and community engagement to make learning relevant and meaningful. Culturally responsive teaching can result in increased student interest, enhanced critical thinking, and stronger connections between home and school. This paper advocates for a culturally inclusive curriculum that reflects Caribbean Culture, more specifically Saint Lucian heritage and empowers students with practical skills for their personal and professional lives.
title: Endoprótesis esofágica
Creators: name: García de las Heras Rodríguez, María
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Prostheses
subject: Obstruction / Occlusion
subject: Neoplasia
subject: Stents
subject: Interventional non-vascular
subject: Stomach (incl. Oesophagus)

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar un protocolo de actuación útil para todo el que se inicia en la radiología intervencionista,
en cuanto a la técnica paso a paso,
indicaciones y contraindicaciones ,
complicaciones y preparación del paciente,
así como su manejo y...
The 2dF galaxy redshift survey: Voids and hierarchical scaling models
Creators: name: Croton, Darren
name: Colless, Matthew
name: Gaztañaga, Enrique
name: Baugh, Carlton M.
name: Norberg, Peder
name: Baldry, I. K.
name: Bland-Hawthorn, J.
name: Bridges, T.
name: Cannon, R.
name: Cole, S.
name: Collins, C.
name: Couch, Warrick
name: Dalton, G.
name: De Propris, R.
name: Driver, S. P.
name: Efstathiou, G.
name: Ellis, R. S.
name: Frenk, C. S.
name: Glazebrook, Karl
name: Jackson, C.
name: Lahav, O.
name: Lewis, I.
name: Lumsden, S.
name: Maddox, S.
name: Madgwick, D.
name: Peacock, J. A.
name: Peterson, B. A.
name: Sutherland, W.
name: Taylor, K.
Publisher: name: Swinburne
Year: 2024

description: We measure the redshift-space reduced void probability function (VPF) for 2dFGRS volume-limited galaxy samples covering the absolute magnitude range MbJ -5log10 h = -18 to -22. Theoretically, the VPF connects the distribution of voids to the moments of galaxy clustering of all orders, and can be used to discriminate clustering models in the weakly nonlinear regime. The reduced VPF measured from the 2dFGRS is in excellent agreement with the paradigm of hierarchical scaling of the galaxy clustering moments. The accuracy of our measurement is such that we can rule out, at a very high significance, popular models for galaxy clustering, including the lognormal distribution. We demonstrate that the negative binomial model gives a very good approximation to the 2dFGRS data over a wide range of scales, out to at least 20 h-1 Mpc. Conversely, the reduced VPF for dark matter in a A cold dark matter ( ACDM) universe does appear to be lognormal on small scales but deviates significantly beyond ∼4 h-1 Mpc. We find little dependence of the 2dFGRS reduced VPF on galaxy luminosity. Our results hold independently in both the North and South Galactic Pole survey regions.
Safety and Side Effects of Using Placenta-Derived Decidual Stromal Cells for Graft-versus-Host Disease and Hemorrhagic Cystitis
Creators: name: Baygan, Arjang
name: Aronsson-Kurttila, Wictor
name: Moretti, Gianluca
name: Tibert, Babylonia
name: Dahllof, Goran
name: Klingspor, Lena
name: Gustafsson, Britt
name: Khoein, Bita
name: Moll, Guido
name: Hausmann, Charlotta
name: Svahn, Britt-Marie
name: Westgren, Magnus
name: Remberger, Mats
name: Sadeghi, Behnam
name: Ringden, Olle
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: graft-versus-host disease
subject: mesenchymal stromal cells
subject: hematopoietic stem cell transplantation
subject: hemorrhagic cystitis
subject: decidual stromal cells
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT). DSCs are more immunosuppressive than MSCs. We assessed adverse events and safety using DSCs among 44 treated patients and 40 controls. The median dose of infused cells was 1.5 (range 0.9–2.9) × 106 DSCs/kg. The patients were given 2 (1–5) doses, with a total of 82 infusions. Monitoring ended 3 months after the last DSC infusion. Three patients had transient reactions during DSC infusion. Laboratory values, hemorrhages, and transfusions were similar in the two groups. The frequency of leukemic relapse (2/2, DSC/controls) and invasive fungal infections (6/6) were the same in the two groups. Causes of death were those seen in HSCT patients: infections (5/3), respiratory failure (1/1), circulatory failure (3/1), thromboembolism (1/0), multiorgan failure (0/1), and GVHD and others (2/7). One-year survival for the DSC patients with GVHD was 67%, which was significantly better than achieved previously at our center. One-year survival was 90% in the DSC-treated HC group. DSC infusions appear safe. Randomized studies are required to prove efficacy.
Development of the tandem oxy-Copeene rearrangement and its application toward natural antibiotic tetrodecamycin
Creators: name: Warrington, Jeffrey M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, Organic.

description: This thesis explores the development of the tandem oxy-Cope/ene rearrangement and its application toward the synthesis of natural antibiotic tetrodecamycin. These studies have been carried out to better understand the chemical synthesis of decalin natural products, and provide a springboard from which further studies can be launched. The first part of the study focueses on the tandem oxy-Cope/ene rearrangement and the unravelling of the intricate aspects governing the selectivity, stereochemistry, and transition state conformers at play. As a result of this study, we have developed a general methodology for rapidly constructing decalins bearing a ring junction alcohol via cascade oxy-Cope/ene rearrangement of 1,2-divinyl cyclohexanols. The second part of this study involved the application of this methodology to the decalin skeleton present in tetrodecamycin. Described in this section is the development of the synthetic chemistry en route to the core of the natural product, along with the serendipitous discovery of a tandem oxy-Cope/Claisen/ene/Claisen rearrangement. Finally, the decalin core provided by the tandem rearrangement was fully functionalised to resemble that of the natural product (including all 6 contiguous stereocentres), and the synthetic efforts toward the completion of tetrodecamycin are described.
Formulaic language in speech fluency development in English as a second language
Creators: name: Wood, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Education, Language and Literature.

description: This thesis is an investigation of the role of formulaic language in second language (L2) speech fluency development, within a cognitive and information processing framework. Fluency has been studied and defined in terms of temporal variables of speech such as rate of speech, pause frequency and distribution, and the length of fluent runs between pauses. It has been suggested by several researchers that the key to fluency in spontaneous speech is mastery of a repertoire of formulaic language sequences, multiword strings processed mentally as single words (Schmidt, 1991; Towell, Hawkins, and Bazergui, 1996; Chambers, 1998). If formulaic sequences are automatized or stored and retrieved as wholes from long term memory so as to allow longer lexical units to be produced within the limits of controlled processing (McLaughlin, Rossman, and McLeod, 1983; Kahnemann and Treismann, 1984; DeKeyser, 2001) and short term memory (Anderson, 1983; Baddeley, 1988), then they may facilitate spontaneous speech under the constraints of real time. The present study was designed to examine whether this could be so. The study draws on a synthesis of research from three areas: fluency and its development in second language (L2) speech; formulaic language, multi-word lexical units which are stored and retrieved in long-term memory so as to be retrieved as wholes; social and cultural factors related to fluency development and formulaic language use, including first language and culture, voice, and identity. The research was interpreted in light of psycholinguistic knowledge about mental processes underlying L2 speech production, particularly the growing evidence that formulaic language sequences are fundamental to fluent language production as they allow production to occur despite the restrictions of controlled processing and the constraints of short term memory capacity. The hypotheses which frame the research centre around the idea that increased use of formulaic language units by learners over time facilitates the development of speech fluency as measured by temporal variables such as speech rate, pause phenomena, and the length of fluent runs occurring between pauses. Specifically, it was hypothesized that, with continued learning and experience, L2 speech would exhibit a faster rate of production, a greater proportion of production time spent speaking as opposed to pausing, longer runs between pauses, and that formulaic sequences would appear more frequently in the longer runs between pauses. (Abstract shortened by UMI.)
WITHDRAWN - a resource for withdrawn and discontinued drugs
Creators: name: Siramshetty, Vishal B.
name: Nickel, Janette
name: Omieczynski, Christian
name: Gohlke, Bjoern-Oliver
name: Drwal, Malgorzata N.
name: Preissner, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Post-marketing drug withdrawals can be associated with various events, ranging from safety issues such as reported deaths or severe side-effects, to a multitude of non-safety problems including lack of efficacy, manufacturing, regulatory or business issues. During the last century, the majority of drugs voluntarily withdrawn from the market or prohibited by regulatory agencies was reported to be related to adverse drug reactions. Understanding the underlying mechanisms of toxicity is of utmost importance for current and future drug discovery. Here, we present WITHDRAWN, a resource for withdrawn and discontinued drugs publicly accessible at http://cheminfo.charite.de/withdrawn. Today, the database comprises 578 withdrawn or discontinued drugs, their structures, important physico-chemical properties, protein targets and relevant signaling pathways. A special focus of the database lies on the drugs withdrawn due to adverse reactions and toxic effects. For approximately one half of the drugs in the database, safety issues were identified as the main reason for withdrawal. Withdrawal reasons were extracted from the literature and manually classified into toxicity types representing adverse effects on different organs. A special feature of the database is the presence of multiple search options which will allow systematic analyses of withdrawn drugs and their mechanisms of toxicity.
Protein characterization by biochemical analysis: MKP3 binding and auto-inhibitory functions Unexpected lability in the SARS nucleocapsid protein
Creators: name: Mark, John K
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Chemistry, Biochemistry.

description: Two proteins were tested using biochemical assay techniques to determine the reasons for their loss of function or loss of primary structure. The first protein that was analysed, MAP kinase phosphatase 3 (MKP3), dephosphorylates the extracellular signal-regulated kinases (ERKs). Dephosphorylation occurs following ERK binding to MKP3's N-terminal domain, which activates MKP3's allosteric C-terminal phosphatase domain. To determine the mechanism for MKP3's loss of function in pancreatic adenocarcinoma cells, experiments were conducted to test the effect of potential protein-protein interactions on MKP3 activity. Surface plasmon resonance binding studies using the full-length MKP3 and N- and C-terminal truncation mutants showed that the N- and C-terminal MKP3 domains could bind with a dissociation constant (KD) of 1.43 +/- 0.41 muM. The low KD value between the two domains is consistent with the presence of an interdomain binding site. A novel MKP3 activity assay was then developed to test if the binding affected MKP3's phosphatase activity. Chemically-activated MKP3 C-terminal domain was capable of hydrolysing p-nitrophenol phosphate with a catalytic efficiency (kcat/KM) ∼33% greater than the full-length MKP3 protein. However, when MKP3 C-terminal domain activity was tested in the presence of the N-terminal domain, the addition led to a dose-dependant inhibition with a KI (inhibition constant) of 0.68 +/- 0.37 muM. The similarity between the KD and K I constants, for MKP3's N- and C-terminal binding and inhibition, implies that MKP3 interdomain binding results in inhibition of MKP3 activity. This finding was compared to experiments showing that pancreatic adenocarcinoma cells contain a non-functional, wild-type MKP3 that forms high molecular weight oligomers. Biochemical analysis and the detection of the oligomers indicates that MKP3 overexpression in adenocarcinomas may lead to a loss of enzyme function through intercalation of N- and C-terminal domains via a "domain swap" interaction that results in MKP3 autoinhibition. The second study was performed on the SARS nucleocapsid (N) protein. N protein displayed an unexpected lability and multiple lower molecular weight bands were detected upon N protein purification. Mass spectrometry was used to identify the bands as the N- and C-terminal fragments of SARS N protein, which result from a specific cleavage after each arginine in the N protein's 184SSRSSSRSRGNSR196 sequence. Fluorescent resonance energy transfer (FRET) based assays that were developed to test for non-specific protease activity showed negative results. This may indicate that the SARS N protein possesses a specific autocatalytic activity.
title: Dilataciones neumáticas en el tratamiento de las estenosis uretrales: Una alternativa eficaz para un viejo problema sin resolver.
Creators: name: Palaña Palau, Pau
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Obstruction / Occlusion
subject: Dilatation
subject: Catheters
subject: Fluoroscopy
subject: Genital / Reproductive system male

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Introducción La estenosis uretral es una patología muy frecuente en el mundo occidental,
con una prevalencia de 1/10000 en hombres menores de 25 años y de 1/1000 en mayores de 65 años.
(fig.
1) Los recientes avances en el campo de la urología...
Συσχέτιση ναυτιλιακών δεδομένων και δεδομένων προωστήριας εγκατάστασης με χρήση προγραμμάτων τεχνητής νοημοσύνης για την πρόβλεψη της κατανάλωσης καυσίμου
Creators: name: Γερουλάνος, Κάρολος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Τεχνητή νοημοσύνη
subject: Μηχανική μάθηση
subject: Πρόβλεψη
subject: Κατανάλωση
subject: Πλοίο
subject: Artificial intelligence
subject: Machine learning
subject: Prediction
subject: Consumption
subject: Ship

description: Το σύγχρονο παγκόσμιο ναυτιλιακό περιβάλλον είναι αντιμέτωπο με πολλές προκλήσεις, με κυριότερες εξ αυτών την εν εξελίξει κλιματική αλλαγή αλλά και την τρέχουσα γεωπολιτική ρευστότητα που επικρατεί σε περιοχές γύρω από τις κυριότερες θαλάσσιες οδούς. Αυτές οι καταστάσεις αποτελούν παράγοντες αποσταθεροποίησης τις παγκόσμιας οικονομίας, προκαλώντας σημαντικές διαταράξεις στην παγκόσμια εφοδιαστική αλυσίδα. Πέραν του οικονομικού αντίκτυπου που παρουσιάζουν οι ανωτέρω καταστάσεις στις εθνικές οικονομίες, επηρεάζουν σημαντικά και την εύρυθμη λειτουργία των ναυτιλιακών εταιρειών, με τις οικονομικές συνέπειες να είναι αρκετές φορές εξαιρετικά αρνητικές. Οι σύγχρονες ναυτιλιακές εταιρείες καλούνται να συμμορφωθούν με τους ολοένα και αυστηρότερους κανονισμούς που επιβάλει ο IMO, οι οποίοι αφορούν την συμμόρφωση με τους κανόνες ασφαλούς ναυσιπλοΐας και την ασφάλεια της ανθρώπινης ζωής στην θάλασσα (SOLAS) αλλά και με την συμμόρφωση με τους περιβαλλοντικούς στόχους για την μείωση των συνολικά εκπεμπόμενων ρύπων έως το έτος 2050 της ναυτιλιακής βιομηχανίας. Η ανάπτυξη σύγχρονων τεχνολογικών εφαρμογών και η ραγδαία εξέλιξη της τεχνητής νοημοσύνης έρχονται για να ενσωματωθούν στην λειτουργία των ναυτιλιακών εταιρειών καθιστώντας τις ναυτιλιακές εταιρείες βιώσιμες και ικανές να επιτύχουν την στοχοθεσία του IMO. Η ενσωμάτωση τεχνικών τεχνητής νοημοσύνης επιτρέπει στις ναυτιλιακές εταιρείες να αναλύουν δεδομένα που προέρχονται από τους στόλους των πλοίων που διαχειρίζονται και να εξάγουν αξιόπιστα συμπεράσματα, τα οποία με την σειρά τους οδηγούν στην λήψη των βέλτιστων αποφάσεων. Οι αποφάσεις αυτές οδηγούν τις ναυτιλιακές εταιρείες στην επίτευξη των στόχων τους και στην οικονομική τους ανάπτυξη καθιστώντας το ναυτιλιακό κλάδο πρωτοπόρο και ηγέτη στην παγκόσμια οικονομία και στην αντιμετώπιση της κλιματικής αλλαγής. Στην παρούσα εργασία γίνεται αναφορά στις προκλήσεις που καλούνται να αντιμετωπίσουν οι ναυτιλιακές εταιρείες. Αναλύεται το θαλάσσιο περιβάλλον καθώς και η επίδρασή του στην λειτουργία ενός πλοίου. Στην συνέχεια γίνεται εκτενής αναφορά σε μεθόδους τεχνητής νοημοσύνης και αναλύονται οι τομείς εφαρμογής τους, όπως η σχεδίαση ενός ταξιδιού, η κατανάλωση καυσίμου και η πρόβλεψη βλαβών με πεδίο εφαρμογής το πλοίο. Τέλος, αναλύονται, αξιολογούνται και συγκρίνονται τα αποτελέσματα που προέκυψαν από την ανάπτυξη τεσσάρων μοντέλων μηχανικής μάθησης με σκοπό την πρόβλεψη της κατανάλωσης καυσίμου ενός πολεμικού πλοίου. Στόχος της παρούσας μελέτης δεν είναι η εκλογή του βέλτιστου μοντέλου πρόβλεψης κατανάλωσης καυσίμου αλλά η απόκτηση περαιτέρω γνώσης με σκοπό την υποβοήθηση της μελλοντικής έρευνας.