cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 79
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 79

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.fa7e5t5u
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa
Creators: name: Gokhan Zengin
name: Menghini, Luigi
name: Malatesta, Luciano
name: Luca, Elisa De
name: Bellagamba, Giuseppe
name: Sengul Uysal
name: Aktumsek, Abdurrahman
name: Locatelli, Marcello
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The multicomponent pattern and biological characterization of plant material are essential for pharmaceutical field, in the food supplements quality control procedures and to all plant-based products. These nutrients often show valuable effects related to their consumption due to the occurrence of secondary metabolites that show useful properties on health. In this framework, researches performed on this topic play a central role for human health and drug development process. The aim of this study was to compare phenolics and free anthraquinones multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa using validated high-performance liquid chromatography–photogiode array (HPLC–PDA) assays, coupled to biological evaluation. Even if some variances related to biological and enzymatic inhibition activities can be ascribed to other phytochemicals, the reported data support traditional use of Asphodeline anatolica and Potentilla speciosa roots as valuable natural font for the development of novel natural-derived drug formulations and/or food supplements with health and nutritional benefits.
Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation
Creators: name: Sundaraj Rajamanikandan
name: Jeyaraman Jeyakanthan
name: Pappu Srinivasan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Master quorum sensing (QS) regulator LuxR of Vibrio harveyi is a unique member of the TetR protein superfamily. Recent studies have demonstrated the contribution of thiazolidinedione analogues in blocking QS by decreasing the DNA-binding ability of LuxR. However, the precise mechanism of thiazolidinedione analogues binding to LuxR is still unclear. In the present study, molecular docking combined with molecular dynamics (MD) simulations was performed to understand the mechanism of ligand binding to the protein. The binding pattern of thiazolidinedione analogues showed strong hydrogen bonding interactions with the amine group (NH) of polar amino acid residue Asn133 and carbonyl (C=O) interaction with negatively charged amino acid residue Gln137 in the binding site of LuxR. The stability of the protein–ligand complexes was confirmed by running 50 ns of MD simulations. Further, the four-featured pharmacophore hypothesis (AHHD) consists of one acceptor (A), two hydrophobic regions (HH) and one donor (D) group was used to screen compounds from ChemBridge database. The identified hit molecules were shown to have excellent pharmacokinetic properties under the acceptable range. Based on the computational studies, ChemBridge_5343641 was selected for in vitro assays. The 1-(4-chlorophenoxy)-3-[(4,6-dimethyl-2-pyrimidinyl)thio]-2-propanol (ChemBridge_5343641) showed significant reduction in bioluminescence in a dose-dependent manner. In addition, ChemBridge_5343641 inhibits biofilm formation and motility in V. harveyi. The result from the study suggests that ChemBridge_5343641 could serve as an anti-QS molecule.
title: 01_0724
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Financial Studio: Android Based Application for Computing Tax, Pension,Zakat and Loan
Creators: name: Zubair Asghar
name: Ulfat Batool, Farheen Bibi
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Software
subject: FOS: Computer and information sciences

description: This work deals with the development of android-based financial studio, an integrated application forcalculating tax, pension, zakat, and loan. Financial studio can facilitate employers of any department and otherindividuals. The application is developed using MIT app inventor-based android platform. The financial studiohas four computational modules, namely: (i) tax, (ii) pension, (iii) zakat, and (iv) loan. The system provides anintegrated environment for performing aforementioned distinct calculations by integrating different financialmodules into a single application in a user-friendly way. The statistical analysis shows that the application iseffective to deal with different financial calculations.
Cuestionario de satisfacción del alumnado con las sesiones virtuales debido al COVID-19
Creators: name: Vílchez, Vera Ferrón
Publisher: name: Zenodo
Year: 2020
Subjects: cuestionario, satisfacción alumnado, docencia virtual

description: Cuestionario de satisfacción del alumnado con las sesiones virtuales debido al COVID-19 durante el confinamiento de marzo y abril de 2020.
Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore based virtual screening in the designing of LuxR inhibitors and its biological evaluation
Creators: name: Sundaraj Rajamanikandan
name: Jeyakanthan Jeyaraman
name: Srinivasan Pappu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Master quorum sensing regulator LuxR of Vibrio harveyi is a unique member of the TetR protein superfamily. Recent studies have demonstrated the contribution of thiazolidinedione analogues in blocking quorum sensing by decreasing the DNA binding ability of LuxR. However the precise mechanism of thiazolidinedione analogues binding to LuxR is still unclear. In the present study, molecular docking combined with molecular dynamics simulations was performed to understand the mechanism of ligand binding to the protein. The binding pattern of thiazolidinedione analogues showed strong hydrogen bonding interactions with the amine group (NH) of polar amino acid residue Asn133 and carbonyl (C=O) interaction with negatively charged amino acid residue Gln137 in the binding site of LuxR. The stability of the protein-ligand complexes was confirmed by running 50 ns of molecular dynamics simulations. Further, the four featured pharmacophore hypothesis (AHHD) consists of one acceptor (A), two hydrophobic regions (HH) and one donor (D) group were used to screen compounds from ChemBridge database. The identified hit molecules were shown to have excellent pharmacokinetic properties under the acceptable range. Based on the computational studies, ChemBridge_5343641 was selected for in vitro assays. The 1-(4-chlorophenoxy)-3-[(4,6-dimethyl-2-pyrimidinyl)thio]-2-propanol (ChemBridge_5343641) showed significant reduction in bioluminescence in a dose dependent manner. In addition, ChemBridge_5343641 inhibits biofilm formation and motility in V. harveyi. The result from the study suggests that ChemBridge_5343641 could serve as an anti-quorum sensing molecule.
Multivariate, quantile regression model coefficient CIs using the empirical variance distribution, in the presence of collinearity
Creators: name: Martin, John
Publisher: name: figshare
Year: 2020
Subjects: subject: Statistics
subject: FOS: Mathematics

description: This paper investigates the full covariance matrix intercept CI estimator required for multivariate performance of the empirical variance distribution (evd) approach (Martin (1-4)), to estimate the confidence interval (CI) bounds of the quantile regression model coefficient estimates (Koencker & Bassett (5)), for unweighted data cases.
The variance inflation factor (VIF) arising from collinearity is shown to be present in the covariance matrix expression for the evd based intercept model coefficient CI but its effect is evenly balanced by a cov(x1,x2) term in the numerator of the intercept CI estimator.
Multivariate, quantile regression model coefficient CIs using the empirical variance distribution, in the presence of collinearity
Creators: name: Martin, John
Publisher: name: figshare
Year: 2016
Subjects: subject: Statistics
subject: FOS: Mathematics

description: This paper investigates the full covariance matrix intercept CI estimator required for multivariate performance of the empirical variance distribution (evd) approach (Martin (1-4)), to estimate the confidence interval (CI) bounds of the quantile regression model coefficient estimates (Koencker & Bassett (5)), for unweighted data cases.
The variance inflation factor (VIF) arising from collinearity is shown to be present in the covariance matrix expression for the evd based intercept model coefficient CI but its effect is evenly balanced by a cov(x1,x2) term in the numerator of the intercept CI estimator.
Tailoring Health Delivery in Hard to Reach Populations in NTDs Executive Summary and Report
Creators: name: Azie, Jacinta
name: Hicks, Sarah
name: Krause, Ana
name: Levin, Carol
name: START Center
Publisher: name: Gates Open Research
Year: 2024

description: The START team conducted an up-to-date literature review on tailoring NTD interventions in hard-to-reach populations and other health areas that have reached similar populations successfully, drawing recommendations and highlighting challenges that can be strengthened for an effective programmatic reach for the NTD PST at The Foundation.
Mapping stakeholders & best practices in the global movement for women's leadership
Creators: name: Ingle, Erin
name: Asa, Nicole
name: Lasata Shrestha
name: Badshah, Akhtar
name: START Center
Publisher: name: Gates Open Research
Year: 2024

description: The START team was tasked with conducting a literature review and key informant interviews to identify best practices in the movement for women's leadership including a deep dive on gender quotas. The team additionally identified key stakeholders and players in this movement and created a framework to map them by influence and relevance to the BMGF strategy.
REFLEXÃO ACERCA DA ADMINISTRATIVIZAÇÃO DO DIREITO PENAL BRASILEIRO (COM A LEI 12.846/2013)
Creators: name: Costa, Daniela Carvalho Almeida Da
name: EDYLENO ITALO SANTOS SODRÉ
Publisher: name: figshare
Year: 2016
Subjects: subject: Law
subject: FOS: Law

description: This construction aims to present, from critical analysis, the current situation of contemporary criminal law and its expansionist trend against the fundamental rights and “Garantista System”, adopted by the Brazilian Constitution. Also aims to address what has been called as Crisis of Criminal Law Classic and the contrast of old paradigms with the current context of increased crime in Brazil, especially as pertains to the practice of acts of corruption, money laundering and the entitled “white-collar crimes”. Finally, points to the solution found by the legislature, the ordinary federal law 12,846 of 2013 (to combat corporate corruption) as an alternative to, given the rigidity of “Garantista System” of the Federal Constitution, improve the efficiency of state in illicit pursuit that cause huge losses to the public.
Anti-Vagrancy, Punishment and Labor Relations in the Context of the Abolition of Slavery in Brazil and the Portuguese Empire (1870–1910)
Creators: name: Terra, Paulo Cruz
Publisher: name: Bonn Center for Dependency and Slavery Studies
Year: 2022
Subjects: subject: Dependency and Slavery Studies
subject: Abolition
subject: Brazil
subject: Portuguese Empire
subject: ddc:980

description: Focusing on the Brazilian and Portuguese Empire contexts, between 1870 and 1910, this text aims to investigate how the slavery abolition process affected the different historical definitions of what constituted vagrancy and how those definitions related to categories such as class, race and gender; and the way punishments for vagrancy changed over time and how those changes were linked to the transformations associated to the new workers’ labor and production relations. This article first explores the effect that the abolition discussions had on the definitions of vagrancy, and what the previous definitions had been. It goes on to show how, in the post abolition period, the concept of vagrancy was expanded to criminalize workers’ practices and behaviors. An important innovation and contribution of this article is that it is the first comparative and connected analysis of the transformations in labor relations in the abolition context in those spaces with the persecution of vagrancy as its central focus.
Harnessing the immune system for the treatment of melanoma: current status and future prospects
Creators: name: Guennoun, Andrea
name: Sidahmed, Heba
name: Maccalli, Cristina
name: Seliger, Barbara
name: Marincola, Francesco M.
name: Bedognetti, Davide
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: When malignant melanoma is diagnosed early, surgical resection is the intervention of choice and is often curative, but many patients present with unresectable disease at later stages. Due to its complex etiology paired with well-documented chemoresistance and high metastatic potential, patients with advanced melanoma had a poor prognosis, and the treatment of this disease remained unsatisfactory for many years. Recently, targeted therapy, immune checkpoint inhibition, or combinatory approaches have revolutionized the therapeutic options of melanoma allowing considerable improvement in disease control and survival. In this review we will summarize these novel therapeutic strategies with particular focus on combinatory immunotherapies and further discuss recent data derived from immunogenomic studies and potential options to improve the therapeutic efficacy of immune modulatory approaches.
Encapsulation of anti-carbonic anhydrase IX antibody in hydrogel microspheres for tumor targeting
Creators: name: Takacova, Martina
name: Hlouskova, Gabriela
name: Zatovicova, Miriam
name: Benej, Martin
name: Sedlakova, Olga
name: Kopacek, Juraj
name: Pastorek, Jaromir
name: Lacik, Igor
name: Pastorekova, Silvia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Encapsulation is a well-established method of biomaterial protection, controlled release, and efficient delivery. Here we evaluated encapsulation of monoclonal antibody M75 directed to tumor biomarker carbonic anhydrase IX (CA IX) into alginate microbeads (SA-beads) or microcapsules made of sodium alginate, cellulose sulfate, and poly(methylene-co-guanidine) (PMCG). M75 antibody release was quantified using ELISA and its binding properties were assessed by immunodetection methods. SA-beads showed rapid M75 antibody release in the first hour, followed by steady release during the whole experiment of 7 days. In contrast, the M75 release from PMCG capsules was gradual, reaching the maximum concentration on the 7th day. The release was more efficient at pH 6.8 compared to pH 7.4. The released antibody could recognize CA IX, and target the CA IX-positive cells in 3D spheroids. In conclusion, SA-beads and PMCG microcapsules can be considered as promising antibody reservoirs for targeting of cancer cells.
Transition énergétique et logistique : les enseignements d'un cas d'étude
Creators: name: Meriem BOUHLALA
Publisher: name: Zenodo
Year: 2025

description: La logistique verte représente une approche novatrice visant à réinventer la chaîne d'approvisionnement pour la rendre plus respectueuse de l'environnement, tout en maintenant son efficacité économique et sa durabilité. Le Maroc s'engage résolument dans cette transition grâce à sa stratégie logistique 2030. Un de ses objectifs majeurs est de favoriser le développement durable du pays en réduisant les émissions du CO2 liées au transport routier des marchandises et en atténuant la congestion routière dans les zones urbaines. L’office chérifien des phosphates, leader mondiale dans l’industrie des phosphates, s’est engagé dans la transformation de sa chaîne logistique en la rendant verte, afin de minimiser son impact sur l’environnement et devenir un des acteurs de la transition durable.  Notre recherche se propose d'examiner les initiatives et actions mises en œuvre par l’Office Chérifien des Phosphates pour promouvoir la logistique verte, d'identifier les obstacles et défis rencontrés, ainsi que d'évaluer les opportunités offertes par cette approche durable.
Teletrabajando en la Universidad de Granada durante el confinamiento
Creators: name: Vílchez, Vera Ferrón
Publisher: name: Zenodo
Year: 2020
Subjects: covid-19, docencia virtual

description: Entrada en la web personal de la autora (http://veraferron.wordpress.com) en la que se explica cómo se está desarrollando la docencia virtual en Universidad de Granada durante marzo y abril de 2020, periodo de confinamiento como consecuencia de la epidemia del coronavirus.
Kauffman’s clock theorem and its generalisation to more complicated structures and surfaces
Creators: name: LE, NGUYEN THANH TUNG
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 490412
subject: Topology
classificationCode: 490499
subject: Pure mathematics not elsewhere classified

description: The thesis aims to generalise Kauffman’s clock theorem as much as possible. We start with a universe, which is a graph where every vertex has four edges incident to it. Putting a marker at each vertex such that every face has exactly one marker except two fixed faces produces a state. The theorem says that the set of states is a lattice under transpositions. We then generalise a universe to a multiverse and prove that the theorem still holds for a multiverse embedded on a surface with more than one boundary component and non-zero genus.
Supramolecular dimeric structures of pyrazole-containing meso-oxo carbaphlorin analogues
Creators: name: Ishida, Masatoshi
name: Fujimoto, Hiroyuki
name: Morimoto, Tatsuki
name: Mori, Shigeki
name: Toganoh, Motoki
name: Shimizu, Soji
name: Furuta, Hiroyuki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Synthesis and properties of a novel meso-oxo carbaphlorin analogue embedded with an N-free pyrazole moiety are described. The N-benzyl precursor was prepared by a [3 + 1]-MacDonald condensation of N-benzyl pyrazole dialdehyde and β-alkyl-substituted tripyrrane dicarboxylic acid and subsequent oxidation by ferric chloride. Upon deprotection of the benzyl group, the resulting N-free oxophlorin analogue formed a unique supramolecular dimer through mutual hydrogen bonding interactions between the pyrazole NH and meso-carbonyl group. The assembled behaviour was characterised by various spectroscopies, X-ray crystallographic analysis and vapour pressure osmometry. Under the similar reaction conditions, the condensation of meso-phenyl-substituted tripyrrane derivative afforded an unprecedented tetrapyrrolic macrocycle fused with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone unit at their α-pyrrolic positions. The X-ray crystallographic analysis of the macrocycle revealed a twisted core structure, and nonaromatic nature was elucidated.
SSHOC'n Tell Challenge - League of Data as a teaser for a data management training
Creators: name: Leenarts, Ellen
Publisher: name: Zenodo
Year: 2022

description: When inviting data supporters and researchers for a data management training, it would be great if we could make them aware of basic knowledge around archiving and publishing research data and the overview presented in the Data Management Expert Guide. For this purpose I will have a closer look at the League of Data game. Basically the game should be fun and not raise questions, but already show how a researcher profits from data management.
Cycloartane triterpenes from Beesia calthaefolia and their anticomplement structure–activity relationship study
Creators: name: Mu, Li-Hua
name: Zhao, Jin-Yuan
name: Zhang, Jing
name: Liu, Ping
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Fifteen cycloartane triterpenes were isolated from Beesia calthaefolia and among them one was new cycloartane triterpenoid. The structure of new compound was determined by the application of spectroscopic analyses and chemical methods. The fifteen compounds were evaluated for their anticomplement activity by classic pathway. The structure–activity relationship analysis indicated that the configurations of 12-OH is preferable to be α than β, and 18-OH can decrease while 15-OH can increase the anticomplement activity, but saponin with both 15-OH and 18-OH lost most of its activity. The glycosyl moiety of most isolated cycloartane triterpenes is xylosyl. When xylosyl was substituted by glucosyl or galactosyl, their anticomplement activities were decreased or increased, respectively. Further structure–activity relationship (SAR) studies must be carried out to achieve general conclusions regarding the effect of further functionalizations on the anticomplement saponins.
Nurturing Leadership from the Bottom Up: Supporting Leadership and Career Aspirations for Sessional Staff
Creators: name: Kanitkar, Ashwini
name: Breault-Hood, Joelle
name: Mears, Jane
name: Gray, Tonia
Publisher: name: Western Sydney University
Year: 2020

description: The higher education experience both shapes the academics' and students' capacity and motivation to contribute to the world as ethical, compassionate and civic-minded global citizens. Western Sydney University has a firm commitment to gender equity embedded into its mission statement. In this report, we demonstrate ways that Western Sydney University can fulfil this commitment and can lead the way in creating a socially just and ecologically responsible social transformation by supporting and nurturing leadership and career aspirations of casual staff.
The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets
Creators: name: T.E. Johnson
name: C.L. Kirkland
name: S.M. Reddy
name: N.J. Evans
name: B.J. McDonald
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Fig S2: Traces
Antifungal Activity of Natural Colourant from M. composita Bark
Creators: name: TRIPATHI, Y.C.
Publisher: name: figshare
Year: 2020
Subjects: subject: 30401 Biologically Active Molecules
subject: FOS: Chemical sciences
subject: 39903 Industrial Chemistry
subject: 30502 Natural Products Chemistry
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry

description: The present study was aimed to evaluate the antifungal efficacy of natural dye obtained from Melia composita bark and its impact on the antimicrobial finishing of different types of textile fabrics. Antifungal activity of M. composita bark dye was assessed against standard strains of five fungi namely Aspergillus flavus, A. niger, A. parasiticus, Fusarium moniliforme and Penicillium canescens using agar-well diffusion method. The minimum inhibitory concentration (MIC) was determined by broth dilution method. The antifungal potency of dyed fabrics (silk, wool, and cotton) against the five test fungi was quantitatively evaluated by reported method. Different treatment doses of natural dye exhibited a varying degree of antifungal activity against the five test fungi. The treatment dose of 100 μg/ml and above were considerably active. Growth inhibition impact of natural dye at 250 μg/ml dose was almost at par with positive control. Maximum growth inhibition in all the five test fungi was evident with 500 μg/ml dose followed by 250 and 100 μg/ml. MIC of the natural dye against test fungi were found in the range of 20.50-23.00 μg/ml. Dyed fabrics of silk, wool, and cotton also showed remarkable antifungal efficacy against all the test fungi. The highest growth reduction was observed in A. parasiticus whereas lowest in P. canescens with the three types of dyed fabrics. Dyed wool fabrics exhibited the maximum growth reduction followed by silk and cotton fabrics. The study revealed the remarkable antifungal activity of natural dye from barks of M. composita; therefore, the plant can be considered as a good source of natural dye with functional properties and can be used in commercial dyeing and protective finishing of different kinds of textile fabrics
Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations
Creators: name: Vidushi Sharma
name: Wakode, Sharad
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations
Antifungal Activity of Natural Colourant from M. composita Bark.pdf
Creators: name: TRIPATHI, Y.C.
Publisher: name: figshare
Year: 2016
Subjects: subject: 30401 Biologically Active Molecules
subject: FOS: Chemical sciences
subject: 39903 Industrial Chemistry
subject: 30502 Natural Products Chemistry
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry

description: The present study was aimed to evaluate the antifungal efficacy of natural dye obtained from Melia composita bark and its impact on the antimicrobial finishing of different types of textile fabrics. Antifungal activity of M. composita bark dye was assessed against standard strains of five fungi namely Aspergillus flavus, A. niger, A. parasiticus, Fusarium moniliforme and Penicillium canescens using agar-well diffusion method. The minimum inhibitory concentration (MIC) was determined by broth dilution method. The antifungal potency of dyed fabrics (silk, wool, and cotton) against the five test fungi was quantitatively evaluated by reported method. Different treatment doses of natural dye exhibited a varying degree of antifungal activity against the five test fungi. The treatment dose of 100 μg/ml and above were considerably active. Growth inhibition impact of natural dye at 250 μg/ml dose was almost at par with positive control. Maximum growth inhibition in all the five test fungi was evident with 500 μg/ml dose followed by 250 and 100 μg/ml. MIC of the natural dye against test fungi were found in the range of 20.50-23.00 μg/ml. Dyed fabrics of silk, wool, and cotton also showed remarkable antifungal efficacy against all the test fungi. The highest growth reduction was observed in A. parasiticus whereas lowest in P. canescens with the three types of dyed fabrics. Dyed wool fabrics exhibited the maximum growth reduction followed by silk and cotton fabrics. The study revealed the remarkable antifungal activity of natural dye from barks of M. composita; therefore, the plant can be considered as a good source of natural dye with functional properties and can be used in commercial dyeing and protective finishing of different kinds of textile fabrics
Characterization of the reaction of decoupling ubiquinone with bovine mitochondrial respiratory complex I
Creators: name: Masuya, Takahiro
name: Okuda, Kenji
name: Murai, Masatoshi
name: Miyoshi, Hideto
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: We previously produced the unique ubiquinone QT (“decoupling” quinone), the catalytic reduction of which in NADH-quinone oxidoreduction with bovine heart mitochondrial NADH-ubiquinone oxidoreductase (complex I) is completely decoupled from proton translocation across the membrane domain. This feature is markedly distinct from those of typical short-chain quinones such as ubiquinone-1. To further characterize the features of the QT reaction with complex I, we herein synthesized three QT analogs, QT2–QT4, and characterized their electron transfer reactions. We found that all aspects of electron transfer (e.g. electron-accepting activity and membrane potential formation) vary significantly among these analogs. The features of QT2 as decoupling quinone were slightly superior to those of original QT. Based on these results, we conclude that the bound positions of QTs within the quinone binding cavity susceptibly change depending on their side-chain structures, and the positions, in turn, govern the behavior of QTs as electron acceptors. Decoupling ubiquinone
Prediction of a novel internal rearrangement of the Insulin Receptor
Creators: name: Sit, Kei C.
name: Lonkhuyzen, Derek Van
name: Walsh, Terry
name: Croll, Tristan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: The insulin receptor (IR) plays critical roles in metabolism and growth, directed by the binding of insulin. Decades of research to understand the mechanism of insulin binding and activation of the IR have identified a region of the receptor, the C-terminal (CT) peptide, to be crucial for insulin binding. In particular, a truncated IR consisting of the first three domains fused to the CT peptide was found to bind insulin with nanomolar affinity, with undetectable binding in the absence of fused or soluble CT peptide. Problematically, all current crystal structures of the IR indicate the fusion point of the CT peptide to the three domains is located far from the position of the CT peptide as resolved in such structures. We have attempted to address this problem using molecular modeling and dynamics simulations. The results led to the identification of a potential inter-domain interaction between the L2 domain and the CT peptide that is not observed in any of the crystal structures of the IR. Investigations into this new interaction found a conformational change that could potentially be in response to insulin binding. Additionally, further simulation work with the new conformation demonstrated its compatibility with the position and orientation of insulin from the latest insulin-bound IR crystal structure.
WP2A9: Synthesis of OA publication: Citizen engagement as a crisis response at higher education institutions in the Baltic states and Ukraine
Creators: name: Dovidonytė, Rasa
name: Tautkevičienė, Gintarė
name: Jonaitytė, Lina
Publisher: name: Zenodo
Year: 2024

description: This synthesis highlights the main aspects of open access publication "Citizen engagement as a crisis response at higher education institutions in the Baltic states and Ukraine" published in peer-reviewed open access journal Nordic Perspective on open Science (NORDIC) on 6th of September, 2024. https://septentrio.uit.no/index.php/nopos/article/view/7508 

This publication was produced as part of Work Package 2 of the EU-funded project Baltics4UA: "Supporting Ukraine through citizen engagement at Baltic Universities'' (https://baltics4ua.eu/, Project Number 2022-2-EE01-KA220-HED-000096422). 

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European  Union nor EACEA can be held responsible for them.
Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb
Creators: name: Yang, Jian-Bo
name: Li, Li
name: Dai, Zhong
name: Wu, Yu
name: Xing-Chao Geng
name: Li, Bo
name: Shuang-Cheng Ma
name: Wang, Ai-Guo
name: Ya-Lun Su
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry

description: Four new dianthrone glycosides, named polygonumnolides C1-C4 (1–4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5–6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1–4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.
Vegetables and Climate Change: Pathways to Resilience
Creators: name: Kuo, C. George
name: Schafleitner, R
name: Schreinemachers, P
name: Wopereis, Marco C.S.
name: World Vegetable Center
Publisher: name: Unknown
Year: 2020
Subjects: subject: CLIMATE CHANGE
subject: NUTRITION
subject: VEGETABLE PRODUCTION SYSTEMS
subject: CLIMATE RESILIENCE
subject: ADAPTATION
subject: PRODUCTIVITY

description: For the past five decades, the World Vegetable Center (WorldVeg) has conducted research to improve vegetable varieties and production systems that are adapted to the high temperatures and weather extremes in the tropical and sub-tropical regions with significant achievements and impact. By leveraging these achievements, WorldVeg is well positioned to expand its research portfolio to develop climate change adaptation and mitigation options along the vegetable value chain. These options should sustain or ideally enhance vegetable productivity and quality when averaged over a number of growing seasons despite climate change, reduce inter-season variability due to weather extremes, and limit post-harvest losses. In this paper, first risks of the vegetable value chain stakeholders to climate change are described. Next, the likely effects of climate change on vegetable productivity, and its subsequent effects along the vegetable value chain are discussed. This is followed by a description of mutually re-enforcing strategies that can be adopted by WorldVeg and partners to build climate resilience along the vegetable value chain.
Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer
Creators: name: Guan, Xin
name: Gao, Meng
name: Xu, Hong
name: Chenghong Zhang
name: Hongyan Liu
name: Lv, Li
name: Deng, Sa
name: Dongyan Gao
name: Tian, Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Utilization of quercetin (QT) in clinics is limited by its instability and poor solubility. To overcome these disadvantages, we prepared QT as QT-loaded PLGA-TPGS nanoparticles (QPTN) and examined its properties and therapeutic efficacy for liver cancer. QT-loaded PLGA nanoparticles (QPN) and QT/coumarin-6-loaded PLGA-TPGS nanoparticles (QCPTN) with coumarin-6 as a fluorescent marker were also prepared to investigate the cellular uptake by HepG2 and HCa-F cells using a confocal laser scanning microscope (CLSM), and their effects on apoptosis of HepG2 cells were assessed with flow cytometry. The results measured using transmission electron microscopy, scanning electron microscopy and size analyses indicated that QPTN were stably dispersed sphere with diameter in the range of 100-200 nm. It indicated that the QT loading and encapsulation efficiency in QPTN reached 21.63% and 93.74%, respectively, and the accumulative drug release of QPTN was 85.8%, the QCPTN uptake in HCa-F and HepG2 cells were 50.87% and 61.09% using HPLC analysis, respectively. The results determined using an Annexin-PI flow cytometry indicated that QPTN could induce HepG2 cell apoptosis in a dose dependent manner. The results of histological examination and HPLC analysis confirmed that QPTN was targeted to liver cells. In vivo analysis using solid tumor-bearing mouse model indicated that QPTN could suppress tumor growth by 59.07%. Moreover, all the studied properties of QPTN were more desirable than those of QT-loaded PLGA nanoparticles (QPN). In conclusion, QPTN could be used as a potential intravenous dosage form for the treatment of liver cancer owing to the enhanced pharmacological effects of QT with increased liver targeting.
Voting under uncertainty: the effect of information in the Scottish independence referendum
Creators: name: Morisi, Davide
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Despite extensive research on campaign effects, the issue of whether information can actually influence vote choice in a campaign remains debatable. This study provides novel evidence of how issue-based arguments influenced voting preferences in the campaign for the 2014 Scottish independence referendum. The findings, based on a lab experiment and a follow-up survey with the experimental subjects, show that provision of information lead to a one-sided persuasion effect, by increasing the support for independence mainly through reduction of indecision. This effect occurred regardless of the possibility to select the arguments and found further confirmation in the actual increase of Yes votes in the referendum. Additional analyses reveal that personal economic expectations significantly moderated the effect of information, since the support for independence increased only among those who did not expect future economic gains. In line with prospect theory, these results suggest that risk-based calculations and economic perceptions prove important determinants of voting decisions, especially in a context of asymmetrical vote choice between an uncertain “Yes for a change” and a safe “No for the status quo”.
MOBILE MAVERICKS: A TWENTY-YEAR RETROSPECTIVE ON ADVANCEMENTS AND CHALLENGES IN LANGUAGE LEARNING
Creators: name: Mei Ling, Chen Wang
Publisher: name: SADI journals
Year: 2024
Subjects: Mobile-assisted language learning
MALL
language education
electronic devices
language acquisition.

description: Mobile-assisted language learning (MALL) has gained significant attention as electronic devices like computers, tablets, and smartphones have become integral to our daily lives. These devices offer a wealth of intelligent applications that can enhance language learning and teaching experiences. Unlike traditional language learning and computer-assisted language learning (CALL), MALL represents an independent mode of language learning that leverages advancements in mobile technology and theories of mobile learning (M-learning). Despite its potential, MALL faces various challenges, including learner reluctance, low satisfaction levels, frequent interruptions, ineffective learning strategies, and limited communication opportunities. To address these issues and enhance the effectiveness of MALL, increased engagement within mobile-assisted classrooms is necessary. This paper provides an in-depth exploration of MALL, delving into its development, research trends, and associated challenges. By gaining a comprehensive understanding of MALL, educators and learners can optimize language performance, foster greater interest in language acquisition, and establish a solid foundation for language teaching and research endeavors
A nonlinear anisotropic inverse method for computational dissection of inhomogeneous planar tissues
Creators: name: Witzenburg, Colleen M.
name: Barocas, Victor H.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Quantification of the mechanical behavior of soft tissues is challenging due to their anisotropic, heterogeneous, and nonlinear nature. We present a method for the ‘computational dissection’ of a tissue, by which we mean the use of computational tools both to identify and to analyze regions within a tissue sample that have different mechanical properties. The approach employs an inverse technique applied to a series of planar biaxial experimental protocols. The aggregated data from multiple protocols provide the basis for (1) segmentation of the tissue into regions of similar properties, (2) linear analysis for the small-strain behavior, assuming uniform, linear, anisotropic behavior within each region, (3) subsequent nonlinear analysis following each individual experimental protocol path and using local linear properties, and (4) construction of a strain energy data set W(E) at every point in the material by integrating the differential stress–strain functions along each strain path. The approach has been applied to simulated data and captures not only the general nonlinear behavior but also the regional differences introduced into the simulated tissue sample.
title: Im „Honigland” Ukraine
Creators: name: Garms, Viktoria
Publisher: name: Fachinformationsdienst Slavistik
Year: 2023
Subjects: subject: Graue Bienen Kurkow, Andrej
subject: Serye pčëly Kurkov, Andrej
subject: 491.8

description: In seinem Roman „Graue Bienen” schickt Andrij Kurkov den Imker Sergej aus dem Donbass auf einen Roadtrip durch die Ukraine – gemeinsam mit seinen Bienenstöcken, um sie vor dem Krieg zu retten. Kurkov braucht das Schlachtfeld nicht, um dennoch eine Geschichte über den Krieg zu erzählen.
description: novinkigegengelesen