cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nitrosative Redox Homeostasis and Antioxidant Response Defense in Disused Vastus lateralis Muscle in Long-Term Bedrest (Toulouse Cocktail Study)
Creators: name: Blottner, Dieter
name: Capitanio, Daniele
name: Trautmann, Gabor
name: Furlan, Sandra
name: Gambara, Guido
name: Moriggi, Manuela
name: Block, Katharina
name: Barbacini, Pietro
name: Torretta, Enrica
name: Py, Guillaume
name: Chopard, Angèle
name: Vida, Imre
name: Volpe, Pompeo
name: Gelfi, Cecilia
name: Salanova, Michele
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: oxidative stress
subject: skeletal muscle redox homeostasis
subject: antioxidant systems
subject: RNS in cell signaling
subject: bedrest muscle disuse
subject: sarcopenia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Increased oxidative stress by reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a major determinant of disuse-induced muscle atrophy. Muscle biopsies (thigh vastus lateralis, VL) obtained from healthy male subjects enrolled in the Toulouse Cocktail bedrest (BR) study were used to assess efficacy of an antioxidant cocktail (polyphenols, omega-3, vitamin E, and selenium) to counteract the increased redox homeostasis and enhance the antioxidant defense response by using label-free LC-MS/MS and NITRO-DIGE (nitrosated proteins), qPCR, and laser confocal microscopy. Label-free LC-MS/MS indicated that treatment prevented the redox homeostasis dysregulation and promoted structural remodeling (TPM3, MYH7, MYBPC, MYH1, MYL1, HRC, and LUM), increment of RyR1, myogenesis (CSRP3), and skeletal muscle development (MUSTN1, LMNA, AHNAK). These changes were absent in the Placebo group. Glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation, fatty acid beta-oxidation, and mitochondrial transmembrane transport were normalized in treated subjects. Proteins involved in protein folding were also normalized, whereas protein entailed in ion homeostasis decreased. NITRO-DIGE analysis showed significant protein nitrosylation changes for CAT, CA3, SDHA, and VDAC2 in Treatment vs. Placebo. Similarly, the nuclear factor erythroid 2-related factor 2 (Nrf-2) antioxidant response element (Nrf-2 ARE) signaling pathway showed an enhanced response in the Treatment group. Increased nitrosative redox homeostasis and decreased antioxidant defense response were found in post-BR control (Placebo, n = 10) vs. the antioxidant cocktail treated group (Treatment, n = 10). Taken together, increased nitrosative redox homeostasis and muscle deterioration during BR-driven physical inactivity were prevented, whereas decreased antioxidant nitrosative stress defense response was attenuated by Treatment suggesting positive effects of the nutritional intervention protocol in bedrest.
Exploring Health Locus of Control and Patient Preferences for the Non-Surgical Management of Osteoarthritis
Creators: name: Kennedy, Bryanne L
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: osteoarthritis
subject: internal-external control
subject: patient preference
subject: conservative treatment
subject: disease management
subject: qualitative research
subject: Health Sciences--Public Health

description: Background:There is no cure for osteoarthritis, and management aims to reduce pain and improve function. Despite guidelines, 61% of people are referred for surgery before trying non-surgical options, and this needs to be further understood. Many factors affect uptake of options, including the osteoarthritis information available to patients. Individual beliefs around who and whatinfluences health, or locus of control, is related to patient preferences for disease management. There is a paucity of literature on locus of control and preferences for osteoarthritis management.Objectives:To identify the factors that patients with hip and knee osteoarthritis consider when choosing management strategies, and to explore their beliefs about who and what influences osteoarthritis symptoms and progression.Methods:Semi-structured interviews with patients who self-reported a diagnosis by a medical professional with hip and/or knee osteoarthritis and had at least one osteoarthritic joint that had not undergone replacement. A multifaceted recruitment approach was used. Interviews were transcribed verbatim and the Braun and Clarke method for thematic analysis was employed.Results:Interviews were conducted with 13 patients from Alberta, Canada. Sixteen factors were identified that participants considered when choosing management strategies. Majority were extrinsic (11), relating to features of programs and services, while five were intrinsic relating to how individual perspectives influence decision making. Three novel factors emerged: 1) whether further management was desired, 2) the prospect of surgery, and 3) participants’ choice inmanagement. Three descriptive themes captured participants’ beliefs about who and what influences their osteoarthritis symptoms and progression: etiology, progression, and symptoms. Most participants believed that others and themselves had some influence over their osteoarthritis symptoms.Conclusions:The findings reinforced that patient’s management decisions for their osteoarthritis were based on the options available to them. This was the first study to explore locus of control in the context of non-surgical osteoarthritis management and provides a point of departure for future work. Factors that patients consider when choosing management strategies were also identifiedthat could be considered for subsequent quantitative research on patient preferences.Keywords: osteoarthritis, internal-external control, patient preference, conservative treatment,disease management, qualitative research
Fabrication and characterization of steel-magnesium laminated metal composites
Creators: name: Che, Hanqing
Publisher: name: University of British Columbia
Year: 2012

description: In this study, interstitial-free steel and commercial purity magnesium sheets were used to fabricate steel-magnesium laminated metal composites by roll bonding at 300℃. It was found that the steel and magnesium can achieve reasonable bonding after a 47% rolling reduction when the volume fraction of the laminate is 10-15% magnesium. The microstructure of the laminated composites was observed with scanning electron microscope. It was found that a continuous interface between the IF steel and the magnesium was produced during the roll bonding process. There was no evidence of intermetallic formation at the interface. A seven layer steel-magnesium laminate was fabricated by accumulative roll bonding at 300℃ with an overall reduction of 77 percent. Through-width cracks were found in the surface steel layers after the one cycle accumulative roll bonding process. The longitudinal cross-sectional microstructure of the laminate revealed that multi-localizations and even fracture occurred in steel layers inside the laminate. The mechanical properties, including tensile behavior, micro-hardness and bending behavior, of the laminated composites were assessed. The tensile property of the laminated composites was compared with those of monolithic steel and magnesium with equivalent deformation amount deformed under the same conditions. It was found that the UTS of the laminated composites obeyed the simple rule of mixtures. The fracture surfaces of the laminated composites were examined with SEM and compared with those of the monolithic IF steel and magnesium rolled under the same conditions. It was found that the fracture modes of each component were different in the laminated composites compared to the monolithic materials. Three-point bending test was conducted and it was observed that no debonding at the interface occurred for moderate strains. To investigate the fracture behavior of the laminats in bending, a series of U-shape bending tests were conducted and the bend tips were observed. Localization of the outer steel layer was observed, followed by the formation of a major crack at 45 degree to the maximum tensile stress direction. Shear cracks in the magnesium core were also found in some places adjacent to the major crack, and delamination between the steel and magnesium layers occurred.
Light ray fluctuation and lattice refinement of simplicial quantum gravity
Creators: name: Jia, Ding
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In several approaches of non-perturbative quantum gravity, a major outstanding problem is to obtain results valid at the infinite lattice refinement limit. Working with Lorentzian simplicial quantum gravity, we compute light ray fluctuation probabilities in 3D and 4D across different lattices. In a simplified refined box model with the Einstein-Hilbert action, numerical results show that lattice refinement does not simply suppress or simply enhance light ray fluctuations, but actually drives very wide and very narrow light probability distributions towards intermediate ones. A comparison across lattices and across couplings reveals numerical hints at a lattice refinement fixed point associated with a universality class of couplings. The results fit the intuition that quantum spacetime fluctuations reflected by light ray fluctuations start wild microscopically and become mild macroscopically. The refined box model is limited by the assumption of a rigid frame at all scales. The present results suggest further studies around the zero-coupling limit to relax the simplifying assumptions of the model.
description: minor updates to improve presentation, 30 pages, 21 figures, matches well with the published version
Near BMN dynamics of the AdS(3) x S(3) x S(3) x S(1) superstring
Creators: name: Rughoonauth, Nitin
name: Sundin, Per
name: Wulff, Linus
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the type IIA AdS(3) x S(3) x M(4) superstring with M(4)=S(3) x S(1) or M(4)=T(4). String theory in this background is interesting because of AdS3/CFT2 and its newly discovered integrable structures. We derive the kappa symmetry gauge-fixed Green-Schwarz string action to quadratic order in fermions and quartic order in fields utilizing a near BMN expansion. As a first consistency check of our results we show that the two point functions are one-loop finite in dimensional regularization. We then perform a Hamiltonian analysis where we compare the energy of string states with the predictions of a set of conjectured Bethe equations. While we find perfect agreement for single rank one sectors, we find that the product SU(2) x SU(2) sector does not match unless the Bethe equations decouple completely. We then calculate 2 to 2 bosonic tree-level scattering processes on the string worldsheet and show that the two-dimensional S-matrix is reflectionless. This might be important due to the presence of massless worldsheet excitations which are generally not described by the Bethe equations.
description: 28 pages; v2: Fixed signs and eq. (B.1), results unchanged, one reference added; v3: Matches published version
Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15
Creators: name: Ivanov, Igor
name: Cruz, Alejandro
name: Zhuravlev, Alexander
name: Di Venere, Almerinda
name: Nicolai, Eleonora
name: Stehling, Sabine
name: Lluch, José M.
name: González-Lafont, Àngels
name: Kuhn, Hartmut
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: lipoxygenases
subject: crystal structure
subject: protein–protein interactions
subject: cooperative effects
subject: molecular dynamics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. In the presence of an active site ligand (the ALOX15 inhibitor RS7) rabbit ALOX15 was crystalized as heterodimer and the X-ray coordinates of the two monomers within the dimer exhibit subtle structural differences. Using native polyacrylamide electrophoresis, we here observed that highly purified and predominantly monomeric rabbit ALOX15 and human ALOX15B are present in two conformers with distinct electrophoretic mobilities. In silico docking studies, molecular dynamics simulations, site directed mutagenesis experiments and kinetic measurements suggested that in aqueous solutions the two enzymes exhibit motional flexibility, which may impact the enzymatic properties.
Acceso Abierto y Ciencia Abierta en LILACS y BIREME/OPS/OMS
Creators: name: Suga, Sueli Mitiko Yano
Publisher: name: Zenodo
Year: 2023
Subjects: Editores LILACS
Revistas LILACS
Buenas prácticas editoriales
Ciencia Abierta
Acesso Abierto

description: Presentación ministrada el 28/06/2023, en el webinario Desafios de la transición desde el Acceso Abierto hacia la Ciencia Abierta en AL&C, de la serie Buenas Prácticas en los Procesos Editoriales de Revistas Científicas para LILACS (2023). •🎬 Grabación: youtu.be/1X-orHl_mSg •📖 Presentaciones: https://bit.ly/revistasLILACS2023
Classical and Quantum Modes of Coupled Mathieu Equations
Creators: name: Landa, H.
name: Drewsen, M.
name: Reznik, B.
name: Retzker, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We expand the solutions of linearly coupled Mathieu equations in terms of infinite-continued matrix inversions, and use it to find the modes which diagonalize the dynamical problem. This allows obtaining explicitly the ('Floquet-Lyapunov') transformation to coordinates in which the motion is that of decoupled linear oscillators. We use this transformation to solve the Heisenberg equations of the corresponding quantum-mechanical problem, and find the quantum wavefunctions for stable oscillations, expressed in configuration-space. The obtained transformation and quantum solutions can be applied to more general linear systems with periodic coefficients (coupled Hill equations, periodically driven parametric oscillators), and to nonlinear systems as a starting point for convenient perturbative treatment of the nonlinearity.
description: 25 pages, v2 adds citations and small corrections
Ubiquitin Signaling Regulates P-Body Assembly
Creators: name: Kedia, Shreeya
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: Ubiquitination
subject: Processing bodies
subject: Gene expression regulation
subject: Neural stem cell homeostasis
subject: Biological Sciences

description: During the development of the central nervous system, neural stem cells give rise to different cell populations including neurons and glia. To en¬sure the genesis of the correct cell populations in the developing brain, there exists and intricate system of gene expression regulation. One such mechanism of gene expression regulation is the presence of membrane-less ribonucleoprotein (RNP) granules in the cell such as Processing bodies (PBs). These dynamic organelles are sites of RNA metabolism that can temporarily sequester mRNAs resulting in translational repression and/or decay. Therefore, to understand the molecular mechanism by which PBs regulate stem cell homeostasis, it is critical to delineate the signaling regulating PB dynamics. To this end, my thesis explores a novel non-proteolytic monoubiquitination-based signaling mechanism, where monoubiquitination of a core PB protein called 4E-T drives PB assembly. Mechanistically, PB dynamics are fine-tuned by a deubiquitinase called Otud4, which deubiquitinates 4E-T to disassemble PBs. This dynamic ubiquitination signaling therefore, functions as an essential molecular switch to coordinate PB dynamics in neural stem cells.
Crossnational divergence in post-OPEC embargo energy policy : foreign policy capacity in Germany and the United States
Creators: name: Barnum, Forrest Scott Lewis
Publisher: name: University of British Columbia
Year: 2012

description: This thesis explains the origins of the differing domestic energy policy regimes in the United States and Germany. Using historical process tracing, the author argues that policy diverged following the 1973-74 Energy embargo. This crisis allowed space for considerable policy innovation in the two nations, but Germany was able to carry out far more extensive domestic reforms. The author argues Germany had a much greater incentive to pursue these often costly policies thanks to its limited foreign policy capacities. This hypothesis is tested using a methodology derived from Alexander George and Andrew Bennett’s work on case studies and a theoretical model based on Terry Karl and Paul Pierson’s analysis of critical junctures and path dependence. The United States, by contrast, was able to execute a solution based on securing external supplies. The thesis concludes by exploring the implications for contemporary energy policy.
Integer Quantum Hall Effect in a Lattice Model Revisited: Kubo Formalism
Creators: name: Dutta, Paramita
name: Maiti, Santanu K.
name: Karmakar, S. N.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate numerically the integer quantum Hall effect (IQHE) in a two-dimensional square lattice with non-interacting electrons subjected to disorder and uniform magnetic field in a direction perpendicular to the lattice plane. We employ nearest-neighbor tight-binding Hamiltonian to describe the system and obtain the longitudinal and transverse conductivities by using Kubo formalism. The interplay between the magnetic field and disorder is also discussed. Our analysis may be helpful in studying IQHE in any discrete lattice model.
description: 7 pages, 7 figures
The Apogee to Apogee Path Sampler
Creators: name: Sherlock, Chris
name: Urbas, Szymon
name: Ludkin, Matthew
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Statistics
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Among Markov chain Monte Carlo algorithms, Hamiltonian Monte Carlo (HMC) is often the algorithm of choice for complex, high-dimensional target distributions; however, its efficiency is notoriously sensitive to the choice of the integration-time tuning parameter. When integrating both forward and backward in time using the same leapfrog integration step as HMC, the set of apogees, local maxima in the potential along a path, is the same whatever point (position and momentum) along the path is chosen to initialize the integration. We present the Apogee to Apogee Path Sampler (AAPS), which uses this invariance to create a simple yet generic methodology for constructing a path, proposing a point from it and accepting or rejecting that proposal so as to target the intended distribution. We demonstrate empirically that AAPS has a similar efficiency to HMC but is much more robust to the setting of its equivalent tuning parameter, the number of apogees that the path crosses. Supplementary materials for this article are available online.
Effects of spatially and temporally heterogeneous human disturbance on littoral benthic communities in large, deep, oligotrophic lakes
Creators: name: Meyer, Michael F
Publisher: name: Zenodo
Year: 2021
Subjects: pharmaceuticals
fatty acids
food webs
stable isotopes
evidence synthesis

description: Ecosystem integrity is threatened by disturbance from human activities. Although disturbances can take many different forms, human disturbances are inherently heterogeneous, as these disturbances tend to occur where and when people are present. This inherent spatio-temporal heterogeneity means that we can investigate how independent and intersecting spatial and temporal components of ecological disturbances can influence biotic communities. Wastewater released into aquatic systems is an example of a high-impact human disturbance that can reshape aquatic communities. Algal communities, especially in oligotrophic lakes, can rapidly assimilate nutrients, causing increased biomass and altered resources for grazers, which may likewise relocate or adjust behavior and physiology to compensate. Despite seeming straightforward, associating times and locations of nutrient loading with explicit biological responses is challenging, as heterogeneities in nutrient loading and biological succession can obfuscate patterns. Using Lake Baikal (Siberia) and Flathead Lake (Montana, U.S.) as study systems, this dissertation investigates how human disturbance can alter nearshore communities in large oligotrophic ecosystems. Despite Baikal being remote and globally the largest lake by volume, low-level sewage pollution is suspected near certain small lakeside settlements. To investigate potential sewage pollution along a 40-km transect, we sampled water column sewage-associated micropollutants (i.e., microplastics and pharmaceuticals and personal care products – PPCPs), algal and macroinvertebrate abundance, as well as fatty acid profiles that provide insights on trophic interactions. Within the U.S. Pacific Northwest, Flathead Lake also is relatively well protected from human influence yet has demonstrated localized signs of sewage pollution. Building on our spatial study at Lake Baikal, we sampled 15 locations in Flathead Lake over four months for PPCPs as well as periphyton composition, stoichiometry, and fatty acids. Together, these studies evaluate how spatio-temporally heterogenous sewage loading can not only influence community composition, but also nutritional content available to the lake’s larger food web. For Lake Baikal and Flathead Lake, these results are timely, as both lakes are experiencing increasing tourism and an aging wastewater management infrastructure. For lakes worldwide, this work details how ecosystems can respond to eutrophication, while also providing data and infrastructure for continued study intensively within systems and extensively across scales.
Motivations for the Soft Wall holographic approach to strong interactions
Creators: name: Afonin, Sergey
name: Solomko, Timofey
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The hypothesis of gauge/gravity correspondence (or holographic duality) from string theory has led to unexpected and challenging ways for description of strongly coupled systems. Such descriptions are given in terms of weakly-coupled higher-dimensional gravitational theories. The holographic ideas have penetrated many branches of theoretical physics. We discuss motivations for the so-called Soft Wall holographic approach to non-perturbative strong interactions and its advantages.
description: 6 pages; Contribution to XVIII International Conference on Symmetry Methods in Physics, 10-16 July, 2022, Erevan, Armenia
Csde1, an RNA Binding Protein, Modulates Neuronal Subtype Specification
Creators: name: Harvey, Emily M.
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: Autism
subject: Biology--Neuroscience
subject: Biology--Molecular
subject: Biology--Genetics
subject: Health Sciences--Human Development

description: Neuronal diversity is the root of complex function in the cerebral cortex. During cortical development, neural stem cells give rise to neurons. Neurons are a diverse cell type and can be grouped into many subtypes, each with distinct functional identities. Neurogenesis and neuronal subtype specification are carefully regulated, both temporally and spatially, by programmed gene expression. One mechanism controlling gene expression is translational regulation, which alters levels of protein synthesis. Translational regulation orchestrated by RNA binding proteins allows dynamic alterations in protein expression. Here I determine that Cold-shock domain containing E1 (Csde1), an RNA binding protein, regulates the specification of neuronal subtypes in the cerebral cortex. In the developing murine cortex, Csde1 is highly expressed in newborn neurons of the cortical plate during development. I show that reduced Csde1 expression alters neuronal subtype in the embryonic and post-natal cortex. Csde1 reduction disrupts the distribution of neuronal subtypes within the cortical plate. Additionally, reduced Csde1 expression increases mixed neuronal subtype identity. Together, this indicates that the specification of neuronal subtypes is subject to translational regulation, and that Csde1 activity is essential for specification of neurons in the cortex.
ROR, El Registro Abierto de Identificadores Persistentes para Organizaciones de Investigación
Creators: name: Gould, Maria
Publisher: name: Zenodo
Year: 2023
Subjects: PIDsLATAM23
Identificadores persistentes
Ciencia Abierta
PIDs
Persistent identifiers
Open Science

description: “Identificadores persistentes (PIDs) y ciencia abierta en Latinoamérica” (#PIDsLATAM23) organizado por DataCite, ORCID y ROR es un evento enteramente dedicado a los identificadores persistentes y la ciencia abierta en la región. Dirigido a directores y gestores de investigación, bibliotecarios y personal técnico, en este encuentro hablamos sobre los beneficios de los identificadores persistentes y cómo su adopción contribuye a la ciencia abierta y a un ecosistema de investigación más abierto y robusto. Este evento se realiza en colaboración con la csv,conf,v7. Esta presentación de Maria Gould ofrece una visión general de ROR en el ecosistema de investigación. -- "Persistent Identifiers (PIDs) and Open Science in Latin America" (#PIDsLATAM23) organized by DataCite, ORCID and ROR is an event entirely dedicated to persistent identifiers and open science in the region. Aimed at research directors and managers, librarians and technical staff, in this meeting we talk about the benefits of persistent identifiers and how their adoption contributes to open science and a more open and robust research ecosystem. This event is held in collaboration with csv,conf,v7. This presentation by Maria Gould provides an overview of ROR in the research ecosystem.
Cerebral Small Vessel Disease: Cognitive Reserve and Mediators of Cognitive Decline
Creators: name: Durrani, Romella
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: Cerebral small vessel disease
subject: cognitive dysfunction
subject: dementia
subject: cognitive reserve
subject: white matter hyperintensity
subject: silent brain infarct
subject: covert brain infarct
subject: silent stroke
subject: covert stroke
subject: cerebrovascular disease
subject: cerebral amyloid angiopathy
subject: Biology--Neuroscience
subject: Health Sciences--Epidemiology
subject: Cognitive

description: Background: Cerebral small vessel disease (CSVD) is the most common type of cerebrovascular disease that contributes to cognitive decline and dementia. However, persons with the same burden of CSVD often have different cognitive outcomes. Cognitive reserve, defined as the ability to tolerate or adapt to pathology, has been suggested to explain these variations. There are limited studies on cognitive reserve in CSVD, as most studies have focused on Alzheimer’s disease (AD). These studies have also focused on education as the proxy of cognitive reserve, with only a few studies looking at other proxies, such as occupation and leisure activities. Additionally, few studies of cognitive reserve have examined other measures of cerebrovascular disease, beyond white matter hyperintensities (WMH). Objectives: Determine whether cognitive reserve mitigates the deleterious effects of CSVD on cognition, and determine the degree to which cerebral amyloid angiopathy (CAA) biomarkers mediate the effects of CAA on cognition.Methods: Data were analyzed from four multicenter, cross-sectional cohorts. Measures of cerebrovascular disease included: brain infarcts, non-lacunar covert brain infarcts (CBI), WMH, vascular lesion burden, and CAA. Measures of cognitive reserve included: education, occupation, social involvement, physical activity, leisure physical activity, household income, marital status, height, stress, and multilingualism. CAA biomarkers included: WMH, cerebrovascular reactivity (CVR), peak width of skeletonized mean diffusivity (PSMD), mean cortical thickness, and mean cortical thickness in an AD meta-region of interest.Results: WMH, non-lacunar CBI, vascular lesion burden, and CAA were associated with lower cognition. Proxies of cognitive reserve were associated with higher cognition. However, cognitive reserve did not modify the association between CSVD and cognition. CVR, PSMD, and mean cortical thickness in regions typically affected by AD accounted for half of the effects of CAA on cognition; PSMD was the largest contributor.Conclusions: This forms the largest body of work on cognitive reserve within CSVD. Strategies to prevent CSVD-related cognitive decline and dementia include: 1) preventing CSVD, 2) enhancing cognitive reserve, thereby independently increasing cognition---however, this does not mitigate the deleterious effects of CSVD on cognition, and 3) in CAA, maintaining white matter integrity and restoring normal cerebrovascular reactivity.
MOESM1 of Efficient 3-hydroxypropionic acid production from glycerol by metabolically engineered Klebsiella pneumoniae
Creators: name: Jiang, Jiaqi
name: Huang, Bing
name: Wu, Hui
name: Li, Zhimin
name: Ye, Qin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1: Figure S1. λ-Red-mediated recombinase assisted gene replacement for dhaT knockout in Klebsiella pneumoniae. Figure S2. A. Confirmation of ldhA deletion in Kp4 by single colony PCR. M, DL2000 Marker; 1, wild-type Kp4 at 2221bp; 2-5, Kp4 ΔldhA::apr at 2773bp. B. Confirmation of dhaT deletion in JJQ01 by single colony PCR. M, DL2000 Marker; 1, wild-type Kp4 at 2642bp; 2-4, Kp4ΔldhAΔdhaT::apr at 2847bp.
A Design Method of Distributed Algorithms via Discrete-time Blended Dynamics Theorem
Creators: name: Kim, Jeong Woo
name: Lee, Jin Gyu
name: Lee, Donggil
name: Shim, Hyungbo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We develop a discrete-time version of the blended dynamics theorem for the use of designing distributed computation algorithms. The blended dynamics theorem enables to predict the behavior of heterogeneous multi-agent systems. Therefore, once we get a blended dynamics for a particular computational task, design idea of node dynamics for individual heterogeneous agents can easily occur. In the continuous-time case, prediction by blended dynamics was enabled by high coupling gain among neighboring agents. In the discrete-time case, we propose an equivalent action, which we call multi-step coupling in this paper. Compared to the continuous-time case, the blended dynamics can have more variety depending on the coupling matrix. This benefit is demonstrated with three applications; distributed estimation of network size, distributed computation of the PageRank, and distributed computation of the degree sequence of a graph, which correspond to the coupling by doubly-stochastic, column-stochastic, and row-stochastic matrices, respectively.
On the equivalence of game and denotational semantics for the probabilistic mu-calculus
Creators: name: Mio, Matteo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: D.2.4, F.3.0, F.4.1

description: The probabilistic (or quantitative) modal mu-calculus is a fixed-point logic de- signed for expressing properties of probabilistic labeled transition systems (PLTS). Two semantics have been studied for this logic, both assigning to every process state a value in the interval [0,1] representing the probability that the property expressed by the formula holds at the state. One semantics is denotational and the other is a game semantics, specified in terms of two-player stochastic games. The two semantics have been proved to coincide on all finite PLTS's, but the equivalence of the two semantics on arbitrary models has been open in literature. In this paper we prove that the equivalence indeed holds for arbitrary infinite models, and thus our result strengthens the fruitful connection between denotational and game semantics. Our proof adapts the unraveling or unfolding method, a general proof technique for proving result of parity games by induction on their complexity.
An Analysis of Dye-Mediated Photo-Oxidation Fixed Bovine Pericardium for Use in Cardiac Surgery
Creators: name: Pattar, Simranjit S
Publisher: name: Graduate Studies
Year: 2022
Subjects: subject: Acellular bioscaffold
subject: Bovine pericardium
subject: Tissue engineering
subject: Photo-fixation
subject: Cardiac remodelling
subject: Health Sciences--Medicine and Surgery

description: Extracellular matrix bioscaffolds have the potential to influence the cardiac microenvironment and to modulate endogenous cellular mechanisms and are therefore a promising forefront for repair and reconstruction in cardiac surgery. In this study, we investigated the biocompatibility and bioinductivity of an acellular bovine pericardium fixed via dye-mediated photo-oxidation on human cardiac fibroblasts. We compared dye-mediated photo- oxidation fixed bioscaffold to glutaraldehyde-fixed and non-fixed bioscaffolds previously characterized in the literature. Human cardiac fibroblasts were seeded on to bioscaffold materials to assess biocompatibility and bioinductivity by specifically characterizing gene expression, secretome, morphology and viability. Dye-mediated photo-oxidation fixed bovine pericardium preserved human cardiac fibroblast phenotype and viability and potentiated a pro-vasculogenic paracrine response. We also compared the tensile properties of each bioscaffold via biomechanical testing. Dye-mediated photo-oxidation fixed bovine pericardium demonstrated increased compliance compared to glutaraldehyde-fixed bioscaffold in response to tensile force. Dye-mediated photo-oxidation fixed bovine pericardium demonstrated enhanced compliance and retained bioinductivity properties which may leverage endogenous reparative pathways. The biocompatibility, bioinductivity, and biomechanical properties of dye-mediated photo-oxidation fixed bovine pericardium demonstrate its feasibility as a bioscaffold for use in cardiac surgery and warrant further investigation for its use as a tool for cardiac repair and regeneration.
Could the dynamical Lorentz symmetry breaking induce the superluminal neutrinos?
Creators: name: Nojiri, Shin'ichi
name: Odintsov, Sergei D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The toy fermion model coupled with Lagrange multiplier constraint field is proposed. The possibility of superluminal neutrino propagation as result of dynamical Lorentz symmetry breaking is studied.
description: LaTeX, 4 pages, version to appear in EPJC Letters
Slowly Decaying Ringdown of a Rapidly Spinning Black Hole: Probing the No-Hair Theorem by Small Mass-Ratio Mergers with LISA
Creators: name: Oshita, Naritaka
name: Tsuna, Daichi
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The measurability of multiple quasinormal (QN) modes, including overtones and higher harmonics, with the Laser Interferometer Space Antenna is investigated by computing the gravitational wave (GW) signal induced by an intermediate or extreme mass ratio merger involving a supermassive black hole (SMBH). We confirm that the ringdown of rapidly spinning black holes are long-lived, and higher harmonics of the ringdown are significantly excited for mergers of small mass ratios. We investigate the measurability and separability of the QN modes for such mergers and demonstrate that the observation of GWs from rapidly rotating SMBHs has an advantage for detecting superposed QN modes and testing the no-hair theorem of black holes.
description: 8 pages, 8 figures, version accepted for publication in PRD
Determining the Association between Continuity of Primary Care and Acute Care Use among Adult Patients with Chronic Kidney Disease in Alberta
Creators: name: Chong, Christy C.E.
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: Ambulatory Care
subject: Chronic Renal Insufficiency
subject: Continuity of Patient Care
subject: Hospitalization
subject: Physician-Patient Relations
subject: Primary Health Care
subject: Health Sciences--Epidemiology
subject: Health Sciences--Health Care Management

description: Background: Acute care use is high among individuals with chronic kidney disease (CKD). It is unclear how relational continuity of primary care influences downstream acute care use. Aim: To determine if poor relational continuity of primary care is associated with higher rates of all-cause and potentially preventable acute care use among adults with CKD. This project had two objectives:1) To describe the relational continuity of primary care received among adults with CKD in Alberta over a 2-year period and,2) To determine if poor relational continuity of care is associated with higher rates of all-cause and CKD-related ACSC hospitalization and ED visits among adults with CKD.Design and Setting: A population-based retrospective cohort study of adults with stages 3 and 4 CKD and at least three visits to a primary care provider between April 1, 2011 to March 31, 2014 in Alberta, Canada.Method: Relational continuity was calculated using the Usual Provider Continuity index and descriptive statistics were used to summarize patient and acute care encounter characteristics. Adjusted rates (per 1,000 person-years) and incidence rate ratios for all-cause and CKD-related ambulatory care-sensitive condition (ACSC) hospitalizations and emergency department (ED) visits were estimated using negative binomial regression modelling. Results: Among 86,475 individuals with CKD, 51.3%, 30.0%, and 18.7% of patients had high, moderate, and poor continuity of primary care, respectively. There were 77,988 all-cause hospitalizations, 204,615 all-cause ED visits, 6,489 (8.3% of all hospitalizations) CKD-related ACSC hospitalizations, and 8,461 (4.1% of all ED visits) CKD-related ACSC ED visits during a median follow-up of 2.3 years. Rates of all-cause hospitalization and ED use increased with poorer continuity of primary care in a stepwise fashion across CKD stages. Poor continuity of primary care was also associated with higher rates of CKD-related ACSC hospitalization and ED visits, particularly among individuals with stage 3 CKD. Conclusion: Poor continuity of care is associated with increased acute care use and targeted strategies are needed to strengthen patient-provider relationships within primary care among those with CKD.
Truly Lorentzian quantum cosmology
Creators: name: Jia, Ding
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum cosmology based on Lorentzian path integrals is a promising avenue. However, many previous works allow non-Lorentzian configurations by integrating the squared scale factor over the whole real line. Here we show that restricting the minisuperspace path integral to Lorentzian configurations with positive squared scale factor can significantly change the expectation values. In addition, this enables the study of causal horizons and their quantum fluctuations, and achieves singularity avoidance trivially by excluding singular minisuperspace geometries as non-Lorentzian. The results indicate that semiclassical saddle point approximation is not always valid in truly Lorentzian quantum cosmology. As a consequence, related works on the tunnelling and no-boundary proposals, bouncing cosmology, and the quantum origin of inflation etc. need to be reexamined.
description: minor updates to improve presentation, 34 pages, 10 figures, matches published version well
Antifungal Activity of an Endophytic Fungus Aspergillus versicolor DYSJ3 from Aphanamixis grandifolia Blume against Colletotrichum musae
Creators: name: Li, Xiaoyu
name: Wu, Yateng
name: Liu, Zhiqiang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: An endophytic fungus strain DYSJ3 was isolated from a stem of Aphanamixis grandifolia Blume, which was identified as Aspergillus versicolor based on the morphological characteristics, internal transcribed spacer (ITS) and calmodulin gene sequences analyses. A. versicolor DYSJ3 exhibited strong antagonistic activity against Colletotrichum musae, C. gloeosporioides and Fusarium oxysporum f. sp. cubense with the inhibition rates of 61.9, 51.2 and 55.3% respectively. The antifungal metabolites mainly existed in the mycelium of A. versicolor DYSJ3, and its mycelial crude extract (CE) had broad-spectrum antifungal activities against plant pathogenic fungi. The CE had a good thermal stability, and the inhibition rate of 100 µg/mL CE against C. musae was above 70.0% after disposing at 120 °C for 1 h. Five secondary metabolites were isolated from the CE and identified as averufanin, ergosterol peroxide, versicolorin B, averythrin and sterigmatocystin. Activity evaluation showed versicolorin B exhibited inhibitory effects on the mycelial growth and conidial germination of C. musae, and sterigmatocystin had a weak inhibitory effect on the mycelial growth of C. musae.
All-Optical Production of a Lithium Quantum Gas Using Narrow-Line Laser Cooling
Creators: name: Duarte, P. M.
name: Hart, R. A.
name: Hitchcock, J. M.
name: Corcovilos, T. A.
name: Yang, T. -L.
name: Reed, A.
name: Hulet, R. G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We have used the narrow $2S_{1/2} \rightarrow 3P_{3/2}$ transition in the ultraviolet (uv) to laser cool and magneto-optically trap (MOT) $^6$Li atoms. Laser cooling of lithium is usually performed on the $2S_{1/2} \rightarrow 2P_{3/2}$ (D2) transition, and temperatures of $\sim$300 $μ$K are typically achieved. The linewidth of the uv transition is seven times narrower than the D2 line, resulting in lower laser cooling temperatures. We demonstrate that a MOT operating on the uv transition reaches temperatures as low as 59 $μ$K. Furthermore, we find that the light shift of the uv transition in an optical dipole trap at 1070 nm is small and blue-shifted, facilitating efficient loading from the uv MOT. Evaporative cooling of a two spin-state mixture of $^6$Li in the optical trap produces a quantum degenerate Fermi gas with $3 \times 10^{6}$ atoms a total cycle time of only 11 s.
description: 5 pages, 4 figures
Cymatodera conflagrata
Creators: name: Rifkind, Jacques
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cleridae
Cymatodera
Cymatodera conflagrata

description:  Cymatodera conflagrata (Klug) (Fig. 3) Specimen Examined. M E X I C O: O a x a c a, Hwy. 190, 9 km E San José de Gracia, 737 m, N16°38.421′, W96°04.051′, 26 June 2013, beating riparian vegetation, J. Rifkind (1, JNRC). This species has previously been recorded from Nayarit, Morelos, Jalisco, Yucatán, Chiapas, and Central America as far south as Panama (Barr 1975 (listed therein as C. geniculata Chevrolat, an unpublished junior synonym); W.F.Barr personal communication).
description: Published as part of Rifkind, Jacques, 2015, A Note on Microhabitataffinities of Mexican Checkered Beetles (Coleoptera: Cleridae), with New Distribution Records for Oaxaca, Mexico, pp. 559-564 in The Coleopterists Bulletin 69 (4) on pages 559-564, DOI: 10.1649/0010-065X-69.4.559, http://zenodo.org/record/5334854
description: {"references": ["Barr, W. F. 1975. Family Cleridae. Vol. 4. Family 73. [pp. 1 - 18]. In: Checklist of the Beetles of North and Central America and the West Indies (R. H. Arnett, editor). Flora and Fauna Publications, Gainesville, FL."]}
Impact of Alterations to Early Life Microbiota (Antibiotics, Prebiotics, and C-Section) on Body Weight and Brain Development
Creators: name: Cho, Nicole A
Publisher: name: Graduate Studies
Year: 2021
Subjects: subject: Microbiota
subject: Nutrition
subject: Behaviour
subject: Microglia
subject: Obesity
subject: Genetics
subject: FOS: Biological sciences
subject: Metabolism
subject: Health Sciences--Nutrition

description: Background: Communication between the gut microbiota, gut, and brain is now known to influence behavior, metabolic health, and immunity. Foods that improve the composition of the gut microbiota as well as factors that can disrupt it during early development are of interest to investigate the origins of and possible therapeutics for chronic diseases like obesity and mood and neurodevelopmental disorders. Objective: This dissertation examines how early life perturbations to gut microbiota, such as maternal antibiotic use, prebiotic consumption, maternal obesity, and C-section (CS) alter microbial, metabolic, behavioral, and brain outcomes. Specifically, the objectives of this thesis were to: 1) assess the impact of CS in offspring of lean and obese dams on offspring obesity risk; 2) examine the impact of CS and maternal prebiotic intake on offspring microglia and neuron morphology; 3) determine the effects of maternal antibiotic/prebiotic intake on offspring behavior and microglia reactivity; 4) investigate the effects of maternal and child antibiotic use on BMI z-score and temperament in 3-year-old children in a clinical cohort.Methods: Animal studies were conducted in Sprague-Dawley rats or NIH Swiss mice. Clinical participant data was accessed from the Alberta Pregnancy and Nutrition Outcomes (APrON) study. Body composition was measured with dual x-ray absorptiometry (DXA). Elevated Plus Maze (EPM), Novel Context Mismatch (NCM), and Sucrose Preference Tests (SPT) were used to assess behavior. Microglia were analyzed using the expression of IBA-1. Gut microbiota was assessed using 16S rRNA gene sequencing, and tissue gene expression was measured using RT-PCR. Temperament data was assessed using the Child Behavior Questionnaire (CBQ).Results: The primary findings from our study objectives were: 1) CS-associated obesity risk in offspring is dependent on maternal obesity status; 2) Maternal prebiotic intake reverses CS-induced alterations to microglia; 3) Antibiotic-induced alterations to microglia are reversed by maternal prebiotic intake; 4) Maternal and child antibiotic use is associated with increased BMI z-score in children. Conclusion: Our results provide evidence that early-life microbial perturbations alter obesity risk and microglia activation. We also demonstrated the potential for prebiotics to reduce the neuroinflammation that could modulate the risk for mood and neuropsychiatric disorders.