cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Creators: name: Knoedler, Leonard
name: Huelsboemer, Lioba
name: Hollmann, Katharina
name: Alfertshofer, Michael
name: Herfeld, Konstantin
name: Hosseini, Helia
name: Boroumand, Sam
name: Stoegner, Viola A.
name: Safi, Ali-Farid
name: Perl, Markus
name: Knoedler, Samuel
name: Pomahac, Bohdan
name: Kauke-Navarro, Martin
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: breast cancer, sarcoma, head and neck cancer, skin cancer, malignant melanoma, monoclonal antibody, immunotherapy, immune checkpoint inhibitors
subject: 610 Medizin

description: Malignancies represent a persisting worldwide health burden. Tumor treatment is commonly based on surgical and/or non-surgical therapies. In the recent decade, novel non-surgical treatment strategies involving monoclonal antibodies (mAB) and immune checkpoint inhibitors (ICI) have been successfully incorporated into standard treatment algorithms. Such emerging therapy concepts have demonstrated improved complete remission rates and prolonged progression-free survival compared to conventional chemotherapies. However, the in-toto surgical tumor resection followed by reconstructive surgery oftentimes remains the only curative therapy. Breast cancer (BC), skin cancer (SC), head and neck cancer (HNC), and sarcoma amongst other cancer entities commonly require reconstructive surgery to restore form, aesthetics, and functionality. Understanding the basic principles, strengths, and limitations of mAB and ICI as (neo-) adjuvant therapies and treatment alternatives for resectable or unresectable tumors is paramount for optimized surgical therapy planning. Yet, there is a scarcity of studies that condense the current body of literature on mAB and ICI for BC, SC, HNC, and sarcoma. This knowledge gap may result in suboptimal treatment planning, ultimately impairing patient outcomes. Herein, we aim to summarize the current translational endeavors focusing on mAB and ICI. This line of research may serve as an evidence-based fundament to guide targeted therapy and optimize interdisciplinary anti-cancer strategies.
Lenoxus Thomas 1909
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Lenoxus

description: Lenoxus Thomas 1909
Lenoxus Thomas 1909, Ann. Mag. Nat. Hist., ser. 8, 4: 236.
Type Species: Oxymycterus apicalis J. A. Allen 1900
Species and subspecies: 1 species:
Species Lenoxus apicalis (J. A. Allen 1900)
Discussion: Akodontini. Viewed as closely related to Oxymycterus by Reig (1987), but electrophoretic data reveal Lenoxus as cladistically removed from Oxymycterus proper (Patton et al., 1989) and gene sequences indicate closer relationship to a clade including Blarinomys, Brucepattersonius, Kunsia, and Scapteromys (D’Elía, 2003; D’Elía et al., 2003; Smith and Patton, 1999).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis
Creators: name: Bajraktari, Ganimete
name: Elger, Tanja
name: Huss, Muriel
name: Loibl, Johanna
name: Albert, Andreas
name: Kandulski, Arne
name: Müller, Martina
name: Tews, Hauke Christian
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: galectin-3; aminotransferase; calprotectin; urine; primary sclerosing cholangitis; inflammatory bowel disease
subject: 610 Medizin

description: Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and inflammatory bowel disease (IBD). This study aims to clarify whether galectin-3 can differentiate between patients with IBD, PSC, and PSC-IBD. Our study measured serum galectin-3 levels in 38 healthy controls, 55 patients with IBD, and 22 patients with PSC (11 patients had underlying IBD and 11 patients did not), alongside the urinary galectin-3 of these patients and 18 controls. Serum and urinary galectin-3 levels in IBD patients were comparable to those in controls. Among IBD patients, those with high fecal calprotectin, indicating severe disease, exhibited lower serum and elevated urinary galectin-3 levels compared to those with low calprotectin levels. Serum galectin-3 levels were inversely correlated with C-reactive protein levels. PSC patients displayed higher serum and urinary galectin-3 levels than IBD patients, with the highest serum levels observed in PSC patients with coexisting IBD. There was no correlation between serum and urinary galectin-3 levels and laboratory indicators of liver injury in both IBD and PSC patients. In conclusion, this study demonstrates that serum and urinary galectin-3 levels can distinguish IBD from PSC patients, and also reveals higher serum galectin-3 levels in PSC-IBD patients compared to those with isolated PSC.
title: Activité du port de Saint-Malo – 1718 – Flamanville
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: matériaux de construction

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1718 avec le port "Flamanville"
description: Marchandises au départ de Saint-Malo : ardoises
description: Catégories de marchandises au départ de Saint-Malo : matériaux de construction
description: Marchandises arrivées à Saint-Malo : bois à bâtir
description: Catégories de marchandises arrivées à Saint-Malo : matériaux de construction
description: Coverage: Petit cabotage
description: Bibliographic citation: RUELLAND, Jean-Marc. Le Commerce malouin durant les années 1717-1718. DES : Histoire : Rennes, s.d. (Bibliothèque François-Lebrun, MH 1022)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
Creators: name: Bruss, Christina
name: Albert, Veruschka
name: Seitz, Stephan
name: Blaimer, Stephanie
name: Kellner, Kerstin
name: Pohl, Fabian
name: Ortmann, Olaf
name: Brockhoff, Gero
name: Wege, Anja K.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: in-situ vaccination, breast cancer, neoadjuvant irradiation, checkpoint therapy, combination therapy, humanized tumor mice (HTM)
subject: 610 Medizin

description: Pre-operative radiation therapy is not currently integrated into the treatment protocols for breast cancer. However, transforming immunological “cold” breast cancers by neoadjuvant irradiation into their “hot” variants is supposed to elicit an endogenous tumor immune defense and, thus, enhance immunotherapy efficiency. We investigated cellular and immunological effects of sub-lethal, neoadjuvant irradiation of ER pos., HER2 pos., and triple-negative breast cancer subtypes in-vitro and in-vivo in humanized tumor mice (HTM). This mouse model is characterized by a human-like immune system and therefore facilitates detailed analysis of the mechanisms and efficiency of neoadjuvant, irradiation-induced “in-situ vaccination”, especially in the context of concurrently applied checkpoint therapy. Similar to clinical appearances, we observed a gradually increased immunogenicity from the luminal over the HER2-pos. to the triple negative subtype in HTM indicated by an increasing immune cell infiltration into the tumor tissue. Anti-PD-L1 therapy divided the HER2-pos. and triple negative HTM groups into responder and non-responder, while the luminal HTMs were basically irresponsive. Irradiation alone was effective in the HER2-pos. and luminal subtype-specific HTM and was supportive for overcoming irresponsiveness to single anti-PD-L1 treatment. The treatment success correlated with a significantly increased T cell proportion and PD-1 expression in the spleen. In all subtype-specific HTM combination therapy proved most effective in diminishing tumor growth, enhancing the immune response, and converted non-responder into responder during anti-PD-L1 therapy. In HTM, neoadjuvant irradiation reinforced anti-PD-L1 checkpoint treatment of breast cancer in a subtype –specific manner. According to the “bench to bedside” principle, this study offers a vital foundation for clinical translating the use of neoadjuvant irradiation in the context of checkpoint therapy.
Current and Future Therapeutic Targets for Directed Molecular Therapies in Cholangiocarcinoma
Creators: name: Heumann, Philipp
name: Albert, Andreas
name: Gülow, Karsten
name: Tümen, Deniz
name: Müller, Martina
name: Kandulski, Arne
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: cholangiocarcinoma; targeted therapy; biliary tract cancer; molecular-directed therapy
subject: 610 Medizin

description: We conducted a comprehensive review of the current literature of published data, clinical trials (MEDLINE; ncbi.pubmed.com), congress contributions (asco.org; esmo.org), and active recruiting clinical trains (clinicaltrial.gov) on targeted therapies in cholangiocarcinoma. Palliative treatment regimens were analyzed as well as preoperative and perioperative treatment options. We summarized the current knowledge for each mutation and molecular pathway that is or has been under clinical evaluation and discussed the results on the background of current treatment guidelines. We established and recommended targeted treatment options that already exist for second-line settings, including IDH-, BRAF-, and NTRK-mutated tumors, as well as for FGFR2 fusion, HER2/neu-overexpression, and microsatellite instable tumors. Other options for targeted treatment include EGFR- or VEGF-dependent pathways, which are known to be overexpressed or dysregulated in this cancer type and are currently under clinical investigation. Targeted therapy in CCA is a hallmark of individualized medicine as these therapies aim to specifically block pathways that promote cancer cell growth and survival, leading to tumor shrinkage and improved patient outcomes based on the molecular profile of the tumor.
Mapping the Invisible: A Framework for Tracking COVID-19 Spread Among College Students with Google Location Data
Creators: name: Krishnan, Prajindra Sankar
name: Chen, Chai Phing
name: Alkawsi, Gamal
name: Tiong, Sieh Kiong
name: Capretz, Luiz Fernando
Publisher: name: arXiv
Year: 2024
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The COVID-19 pandemic and the implementation of social distancing policies have rapidly changed people's visiting patterns, as reflected in mobility data that tracks mobility traffic using location trackers on cell phones. However, the frequency and duration of concurrent occupancy at specific locations govern the transmission rather than the number of customers visiting. Therefore, understanding how people interact in different locations is crucial to target policies, inform contact tracing, and prevention strategies. This study proposes an efficient way to reduce the spread of the virus among on-campus university students by developing a self-developed Google History Location Extractor and Indicator software based on real-world human mobility data. The platform enables policymakers and researchers to explore the possibility of future developments in the epidemic's spread and simulate the outcomes of human mobility and epidemic state under different epidemic control policies. It offers functions for determining potential contacts, assessing individual infection risks, and evaluating the effectiveness of on-campus policies. The proposed multi-functional platform facilitates the screening process by more accurately targeting potential virus carriers and aids in making informed decisions on epidemic control policies, ultimately contributing to preventing and managing future outbreaks.
description: 8 pages
Health Literacy in Pediatric Consultations on Allergy Prevention
Creators: name: von Sommoggy, Julia
name: Skiba, Eva-Maria
name: Lander, Jonas
name: Apfelbacher, Christian J.
name: Curbach, Janina
name: Brandstetter, Susanne
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: Background:
The first 3 years of life offer an opportunity to prevent allergic diseases. Pediatricians are an important source of health information for parents. However, a certain degree of health literacy is necessary to understand, appraise, and apply preventive behavior, which can be supported by health literacy (HL) sensitive consultations and a HL friendly environment.
Objective:
In this study, we want to shed light on how pediatricians in outpatient care in Germany advise on early childhood allergy prevention (ECAP) and how they consider parental HL.
Methods:
We conducted 19 semi-standardized telephone interviews with pediatricians from North-Rhine-Westphalia and Bavaria. The interviews were audio-recorded, transcribed, pseudonymized, and subjected to content analysis.
Key Results:
Current ECAP recommendations were well known among our sample. Despite the shift of evidence from avoidance of allergens toward early exposure, providing advice on ECAP was considered non-controversial and it was widely assumed that recommendations were easy to understand and apply for parents. However, ECAP was treated as an implicit topic resonating among others like infant nutrition and hygiene. Regarding HL, our interview partners were not aware of HL as a concept. However, they deemed it necessary to somehow assess parental information level and ability to understand provided information. Formal HL screening was not applied, but implicit strategies based on intuition and experience. Concerning effective HL-sensitive communication techniques, interviewees named the adaptation of language and visual support of explanations. More advanced techniques like Teach Back were considered too time-consuming. Medical assistants were considered important in providing an HL-sensitive environment. Time constraints and the high amount of information were considered major barriers regarding HL-sensitive ECAP counseling.
Conclusion:
It seems warranted to enhance professional education and training for pediatricians in HL and HL-sensitive communication, to reach all parents with HL-sensitive ECAP counseling. [HLRP: Health Literacy Research and Practice. 2024;8(2):e47–e61.]
Plain Language Summary:
We asked pediatricians how they advise parents on prevention of allergy in children. We found that pediatricians were well aware of the recommendations on allergy prevention, but they did not pass on all the information to parents. The HL of parents (that is the ability to find, understand, appraise, and apply health information) was not an important issue for the doctors.
Impressive Short-Term Improvement in Functional Outcome and Quality of Life after Primary Total Hip Arthroplasty (THA) in the Orthogeriatric Patient in a Prospective Monocentric Trial
Creators: name: Reinhard, Jan
name: Michalk, Katrin
name: Schiegl, Julia Sabrina
name: Pagano, Stefano
name: Grifka, Joachim
name: Maderbacher, Günther
name: Meyer, Matthias
name: Kappenschneider, Tobias
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: orthogeriatric patients; primary total hip arthroplasty (primary THA); elderly patients; older patients; geriatric patients; frailty; EQ5D-5L; WOMAC; comprehensive geriatric assessment (CGA)
subject: 610 Medizin

description: Background/Objectives: Osteoarthritis (OA) represents the most frequent chronic joint disease worldwide. Facing an aging population, resulting from the demographic change, the number of primary total hip arthroplasties (THA) will further increase. Although the geriatric patient strongly differs from the younger one, the current literature on elective orthopedic surgery in the geriatric patient is scarce. This work analyses, whether geriatric patients receiving primary THA significantly improve in terms of their (1) mobility and functional outcome and (2) health-related quality of life at four to six weeks as well as three months postoperatively. Methods: In a prospective study design, we analyzed 101 geriatric patients with osteoarthritis of the hip receiving primary THA. The study is part of the ongoing “Special Orthopaedic Geriatrics” (SOG) trial, which is funded by the German Federal Joint Committee (GBA). In addition to a preoperative comprehensive geriatric assessment (CGA), the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the EQ5D-5L were imposed preoperatively (t0), at four to six weeks (t1), and at three months (t2) postoperatively. Results: The 101 enrolled patients had a mean age of 78.1 ± 4.9 years. The total WOMAC score and almost all subcategories significantly improved at four to six weeks as well as three months postoperatively in comparison to the preoperative results (p < 0.001). The same was observed for the EQ-5D-5L, showing significant improvement in overall health at both time points (p < 0.001) and all subcategories (p < 0.05). Conclusions: This study implies that a geriatric patient benefits as much from elective primary THA as a younger patient. However, the preoperative comprehensive geriatric assessment with screening for risk factors is of utmost importance. Regarding the aging population, a lot of effort is needed to obtain more knowledge about geriatric patients receiving elective orthopedic surgery.
Sleep-Disordered Breathing, Advanced Age, and Diabetes Mellitus Are Associated with De Novo Atrial Fibrillation after Cardiac Surgery
Creators: name: Tafelmeier, Maria
name: Kuettner, Sabrina
name: Hauck, Christian
name: Floerchinger, Bernhard
name: Camboni, Daniele
name: Creutzenberg, Marcus
name: Zeman, Florian
name: Schmid, Christof
name: Maier, Lars Siegfried
name: Wagner, Stefan
name: Arzt, Michael
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: coronary artery bypass grafting (CABG); coronary artery disease; sleep apnea; postoperative complications
subject: 610 Medizin

description: Background: Postoperative de novo atrial fibrillation (POAF) is one of the most frequently encountered complications following cardiac surgery. Despite the identification of several risk factors, the link between sleep-disordered breathing (SDB) and POAF has barely been examined. The objective of this prospective observational study was to determine whether severe SDB is associated with POAF in patients after elective coronary artery bypass grafting (CABG) surgery. Study design and methods: The incidence and preoperative predictors of in-hospital POAF were assessed in 272 patients undergoing CABG surgery at the University Medical Center Regensburg (Germany). In-hospital POAF was detected by continuous telemetry-ECG monitoring and 12-lead resting ECGs within the first seven postoperative days. POAF that occurred after hospital discharge within 60 days post CABG surgery was classified as post-hospital POAF and was ascertained by standardized phone interviews together with the patients’ medical files, including routinely performed Holter-ECG monitoring at 60 days post CABG surgery. The night before surgery, portable SDB monitoring was used to assess the presence and type of severe SDB, defined by an apnea–hypopnea index ≥ 30/h. Results: The incidence of in-hospital POAF was significantly higher in patients with severe SDB compared to those without severe SDB (30% vs. 15%, p = 0.009). Patients with severe SDB suffered significantly more often from POAF at 60 days post CABG surgery compared to patients without severe SDB (14% vs. 5%, p = 0.042). Multivariable logistic regression analysis showed that severe SDB (odds ratio, OR [95% confidence interval, CI]: 2.23 [1.08; 4.61], p = 0.030), age ≥ 65 years (2.17 [1.04; 4.53], p = 0.038), and diabetes mellitus (2.27 [1.15; 4.48], p = 0.018) were significantly associated with in-hospital POAF. After additional adjustment for heart failure, the association between sleep apnea and postoperative atrial fibrillation was attenuated (1.99 [0.92; 4.31], p = 0.081). Conclusions: Amongst established risk factors, severe SDB was significantly associated with in-hospital POAF in patients undergoing CABG surgery. Whether SDB contributes to POAF independently of heart failure and whether risk for POAF may be alleviated by proper treatment of SDB merits further investigation.
Lenoxus apicalis
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Lenoxus
Lenoxus apicalis

description: Lenoxus apicalis (J. A. Allen 1900)
[Oxymycterus] apicalis J. A. Allen 1900, Bull. Am. Mus. Nat. Hist., 13: 224.
Type Locality: Perú, Puno Dept., Valley of Río Inambari, Santo Domingo Mine, 6000 ft (1830 m).
Vernacular Names: White-tailed Akodont.
Synonyms: Lenoxus boliviae Sanborn 1950.
Distribution: Cloud forest of E Andean slopes, about 1500-2500 m, in SE Perú and WC Bolivia (La Paz Dept.).
Conservation: IUCN – Lower Risk (nt).
Discussion: Anderson (1997) used boliviae as subspecies for the Bolivian populations.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1123, DOI: 10.5281/zenodo.7316535
Eŭrazio ekde 1928 ĝis 1932 per biciklo kaj Esperanto : Eltiroj de ĉiuj personaj notoj (p. 223)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Eltiraĵoj
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis
Creators: name: Fererberger, Tanja
name: Buechler, Christa
name: Kandulski, Arne
name: Elger, Tanja
name: Loibl, Johanna
name: Schmid, Stephan
name: Sommersberger, Stefanie
name: Gunawan, Stefan
name: Zundler, Sebastian
name: Huss, Muriel
name: Bettenworth, Dominik
name: Kempa, Sally
name: Weidlich, Simon
name: Föh, Bandik
name: Huang, Xinyu
name: Grzegorzek, Marcin
name: Derer-Petersen, Stefanie
name: Günther, Ulrich L.
name: Marquardt, Jens U.
name: Kunst, Claudia
name: Gülow, Karsten
name: Müller, Martina
name: Sina, Christian
name: Schmelter, Franziska
name: Tews, Hauke Christian
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: PSC, IBD, NMR, metabolome, lipidome
subject: 610 Medizin

description: Intoduction: Identification of specific metabolome and lipidome profile of
patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis,
targeted personalized therapy, and more accurate risk stratification.
Methods: Nuclear magnetic resonance (NMR) spectroscopy revealed an
altered metabolome and lipidome of 33 patients with PSC [24 patients with
inflammatory bowel disease (IBD) and 9 patients without IBD] compared with
40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as
well as 64 patients with IBD and other extraintestinal manifestations (EIM) but
without PSC.
Results: In particular, higher concentrations of pyruvic acid and several
lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical
relevance, a specific amino acid and lipid profile was determined in PSC
compared with IBD and other EIM.
Discussion: These results have the potential to improve diagnosis by
differentiating PSC patients from HC and those with IBD and EIM.
Unraveling the Role of Reactive Oxygen Species in T Lymphocyte Signaling
Creators: name: Gülow, Karsten
name: Tümen, Deniz
name: Heumann, Philipp
name: Schmid, Stephan
name: Kandulski, Arne
name: Müller, Martina
name: Kunst, Claudia
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: T lymphocytes; reactive oxygen species (ROS); oxidative signal; T cell activation; T cell receptor (TCR); electron transport chain (ETC); glycolysis; metabolic shift
subject: 610 Medizin

description: Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized and transient effects are due to their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I and III of the electron transport chain (ETC). Subsequent ROS production triggers the activation of nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2), prolonging the oxidative signal. This signal then engages kinase signaling cascades such as the mitogen-activated protein kinase (MAPK) pathway and increases the activity of REDOX-sensitive transcription factors such as nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1). To limit ROS overproduction and prevent oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant proteins such as superoxide dismutases (SODs) finely regulate signal intensity and are capable of terminating the oxidative signal when needed. Thus, oxidative signals, such as T cell activation, are well-controlled and critical for cellular communication.
title: Activité du port de Saint-Malo – 1736 – Plouezec
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: céréales
subject: fruits et légumes

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1736 avec le port "Plouezec"
description: Marchandises au départ de Saint-Malo : blé noir ; mouture
description: Catégories de marchandises au départ de Saint-Malo : produits agroalimentaires ; céréales
description: Marchandises arrivées à Saint-Malo : navets
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; fruits et légumes
description: Coverage: Petit cabotage
description: Bibliographic citation: OLLIVIER, Anne-Marie. Le Commerce malouin en 1736. DES : Histoire : Rennes : 1965 (Bibliothèque François-Lebrun, MH 1032)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Epacmoides biumbonatus Bezzi 1922
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Epacmoides
Epacmoides biumbonatus

description: Epacmoides biumbonatus (Bezzi, 1922)
(Figs. 31–32)
53. Plesiocera biumbonata 1Ψ South Africa (Eastern Cape): Willowmore (H. Brauns). MS page 64.
Bezzi, 1922: 83 – key and label data ‘ex Willowmore, 20 Jan. 1907, in Museo Budapestinensi’ but sex not mentioned.
Bezzi, 1925: 298 – key and reference to information in Bezzi (1922).
Hesse, 1956: 130 – description as E. albifrons Hesse and E. albifrons var. pallidulus Hesse. Evenhuis & Greathead, 1999: 420 – listed one syntype in MSNM.
Types: The specimen in MSNM: South Africa (Eastern Cape): 1ɗ, Willowmore, 20.1.1907 (Dr Brauns) is considered here a syntype male. Since the female in HNHM is destroyed, the MSNM male is the only surviving syntype, which is here designated lectotype (Fig. 31).
Remarks: In the Hungarian Museum manuscript, Bezzi, appended a note to his descrip­
tion detailing how the male specimen sent to him by Dr Brauns differed from the female. It
corresponds with the specimen in MSNM now designated lectotype.
It is clear that Hesse (1956) misidentified E. biumbonata as another species without dense chalky white scaling on the frons, which is very distinct in the male specimen in Bezzi’s collection (Fig. 32). Thus, E. albifrons Hesse SYN. NOV. and E. albifrons var. pallida Hesse SYN. NOV., the latter of which is barely distinct from the nominate variety, are synonyms of E. biumbonata (Bezzi).
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 45, DOI: 10.5281/zenodo.158466
Midterm survival and risk factor analysis in patients with pyogenic vertebral osteomyelitis: a retrospective study of 155 cases
Creators: name: Schindler, Melanie
name: Walter, Nike
name: Reinhard, Jan
name: Pagano, Stefano
name: Szymski, Dominik
name: Alt, Volker
name: Rupp, Markus
name: Lang, Siegmund
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: vertebral osteomyelitis (VO), mortality, pathogens, spine infection, comorbidities
subject: 610 Medizin

description: Background: Pyogenic vertebral osteomyelitis (VO) represents a clinical
challenge and is linked to substantial morbidity and mortality. This study aimed
to examine mortality as well as potential risk factors contributing to in-hospital
mortality among patients with VO.
Methods: This retrospective analysis involved patients receiving treatment for VO
at University Regensburg in Germany from January 1, 2000, to December 3,
2020. It included in-hospital mortality rate, comorbidities and pathogens.
Patients were identified using ICD-10 diagnosis codes: M46.2, M46.3, M46.4,
and M46.5. Kaplan–Meier probability plots and odds ratios (OR) for mortality
were calculated.
Results: Out of the total cohort of 155 patients with VO, 53 patients (34.1%) died
during a mean follow-up time of 87.8 ± 70.8 months. The overall mortality was
17.2% at one year, 19.9% at two years and 28.3% at five years. Patients with
congestive heart failure (p = 0.005), renal disease (p < 0.001), symptoms of
paraplegia (p = 0.029), and sepsis (p = 0.006) demonstrated significantly
higher overall mortality rates. In 56.1% of cases, pathogens were identified,
with Staphylococcus aureus (S. aureus) and other unidentified pathogens
being the most common. Renal disease (OR 1.85) and congestive heart failure
(OR 1.52) were identified as significant risk factors.
Conclusion: Early assessment of the specific risk factors for each patient may
prove beneficial in the management and treatment of VO to reduce the risk of
mortality. These findings demonstrate the importance of close monitoring of
VO patients with underlying chronic organ disease and early identification and
treatment of sepsis. Prioritizing identification of the exact pathogens and antibiotic
sensitivity testing can improve outcomes for patients in this high-risk group.
Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity
Creators: name: Brunner, Sarah
name: Höring, Marcus
name: Liebisch, Gerhard
name: Schweizer, Sabine
name: Scheiber, Josef
name: Giansanti, Piero
name: Hidrobo, Maria
name: Hermeling, Sven
name: Oeckl, Josef
name: Prudente de Mello, Natalia
name: Perocchi, Fabiana
name: Seeliger, Claudine
name: Strohmeyer, Akim
name: Klingenspor, Martin
name: Plagge, Johannes
name: Küster, Bernhard
name: Burkhardt, Ralph
name: Janssen, Klaus-Peter
name: Ecker, Josef
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by comparison of proteomes with ER and mitochondria-associated membranes. A lipid signature containing PC and FC, calculated from the lipidomic profiles, allowed differentiation of mitochondria from BAT of mice housed at different temperatures. Elevating FC in BAT mitochondria prevented uncoupling protein (UCP) 1 function, whereas increasing GPL boosted it. Similarly, STARD3 overexpression facilitating mitochondrial FC import inhibited UCP1 function in primary brown adipocytes, whereas a knockdown promoted it. We conclude that the mitochondrial GPL/FC ratio is key for BAT function and propose that targeting it might be a promising strategy to promote UCP1 activity.
title: Lettre n°210 de Paul d'Estournelles de Constant à Nicholas Murray Butler (17 janvier 1917)
title: Letter number 210 from Paul d'Estournelles de Constant to Nicholas Murray Butler (January 17, 1917)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Loxodontomys Osgood 1947
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Loxodontomys

description: Loxodontomys Osgood 1947
Loxodontomys Osgood 1947, J. Mammal., 28: 172.
Type Species: Mus micropus Waterhouse 1837
Species and subspecies: 2 species:
Species Loxodontomys micropus (Waterhouse 1837)
Species Loxodontomys pikumche Spotorno, Cofre, Manriquez, Vilina, Marquet, and Walker 1998
Discussion: Phyllotini. Diagnosed as a subgenus of Phyllotis and maintained at that rank (Pearson, 1958) or as a full synonym (Hershkovitz, 1962). Transferred to Auliscomys, employed as a genus, by Simonetti and Spotorno (1980). Based on morphological studies, however, the species do not cladistically nest within Auliscomys or Phyllotis proper but instead are associated with a clade containing Reithrodon and variably other genera (Braun, 1993; Spotorno et al., 1998; Steppan, 1993, 1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1123, DOI: 10.5281/zenodo.7316535
Una lectura de la Agenda 2030 desde el paradigma de la sostenibilidad socioecológica e intercultural
Creators: name: Sianes, Antonio
name: Herrera-Arango, Johana
name: Pérez-Martínez, Manuel Enrique
name: Serrano, Laura
name: Vela-Jiménez, Rocio
name: Gómez, Carmen Ana Castaños
name: de Frutos, Juan Antonio Senent
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 410402
subject: Environmental assessment and monitoring
classificationCode: 410401
subject: Conservation and biodiversity
classificationCode: 379901
subject: Earth system sciences
classificationCode: 440406
subject: Rural community development
classificationCode: 440407
subject: Socio-economic development

description: La Agenda 2030 constituye un marco global de referencia para promover procesos de desarrollo social, económico y ambiental. Sin embargo, su adecuada territorialización presenta notorios de-safíos, al ser una agenda compleja y multidimensional, requiere interpretaciones localizadas. Pre-sentamos una lectura de dicha Agenda en territorios costeros de comunidades pesqueras vulne-rables que puede ayudar a promover la sostenibilidad socioecológica interculturalmente. En estos ámbitos, las dinámicas socioculturales y los impactos ambientales están dejando al margen a este tipo de comunidades que mantienen formas de vida tradicionales e identitarias de profesión, así como un conocimiento para el cuidado y desarrollo de un modo de vida en estos espacios socioe-cológicos. Empleamos el método Delphi y el diálogo entre comunidades pesqueras en Andalucía y Caribe colombiano y expertos, para crear de manera conjunta un sistema de indicadores que, adaptando los de la Agenda 2030, permita dar seguimiento a los retos de desarrollo que afrontan.
Insights in Molecular Therapies for Hepatocellular Carcinoma
Creators: name: Heumann, Philipp
name: Albert, Andreas
name: Gülow, Karsten
name: Tümen, Deniz
name: Müller, Martina
name: Kandulski, Arne
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: hepatocellular carcinoma; targeted therapy; molecular directed therapy
subject: 610 Medizin

description: We conducted a comprehensive review of the current literature of published data and clinical trials (MEDLINE), as well as published congress contributions and active recruiting clinical trials on targeted therapies in hepatocellular carcinoma. Combinations of different agents and medical therapy along with radiological interventions were analyzed for the setting of advanced HCC. Those settings were also analyzed in combination with adjuvant situations after resection or radiological treatments. We summarized the current knowledge for each therapeutic setting and combination that currently is or has been under clinical evaluation. We further discuss the results in the background of current treatment guidelines. In addition, we review the pathophysiological mechanisms and pathways for each of these investigated targets and drugs to further elucidate the molecular background and underlying mechanisms of action. Established and recommended targeted treatment options that already exist for patients are considered for systemic treatment: atezolizumab/bevacizumab, durvalumab/tremelimumab, sorafenib, lenvatinib, cabozantinib, regorafenib, and ramucirumab. Combination treatment for systemic treatment and local ablative treatment or transarterial chemoembolization and adjuvant and neoadjuvant treatment strategies are under clinical investigation.
Is the Tendon-to-Groove Ratio Associated with Elevated Risk for LHB Tendon Disorders?—A New Approach of Preoperative MR-Graphic Analysis for Targeted Diagnosis of Tendinopathy of the Long Head of Biceps
Creators: name: Gerhardinger, Kristina
name: Klute, Lisa
name: Pfeifer, Christian
name: Straub, Josina
name: Hechinger, Laura
name: Riedl, Moritz
name: Alt, Volker
name: Kerschbaum, Maximilian
name: Henssler, Leopold
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: shoulder; biceps tendon; intertubercular groove; arthroscopy; pulley lesions
subject: 610 Medizin

description: Background: Pathologies of the long head of the biceps (LHB) tendon are a common cause of anterior shoulder pain. While the influence of the anatomical morphology of the intertubercular groove (ITG) on the development of LHB tendon instability has been investigated with ambiguous results, the relationship of the LHB to ITG anatomy has not yet been considered in this context. The objective of this study was to reliably extract the tendon-to-groove ratio from MRI scans of symptomatic patients and examine its potential influence on the occurrence of certain causes for LHB-associated symptoms. Methods: In this retrospective study, preoperative MRI scans of 35 patients (mean age of 46 ± 14 years) presenting with anterior shoulder pain and clinical indications of LHB tendinopathy were analyzed in transversal planes. Long and short diameters of the LHB tendon and ITG were measured, cross-sectional areas of the LHB tendon and ITG were calculated from these measurements, and the ratio of cross-sectional areas (LHB/ITG) was introduced. All measurements were repeated independently by three investigators and inter-rater reliability was assessed using intraclass correlation coefficient (ICC). Thereafter, tendon-to-groove ratios were compared in patients with and without intraoperative signs of LHB tendon instability. Results: All patients exhibited intraoperative signs of LHB tendinitis, with additional findings including pulley lesions and SLAP lesions. Analysis revealed variations in the dimensions of the LHB tendon and ITG cross sections, with the tendon-to-groove ratio decreasing from 37% at the pulley to 31% at the deepest point of the sulcus. Very good inter-rater reliability was observed for all measurements. The tendon-to-groove ratio did not significantly differ (p > 0.05) in patients with or without pulley lesions or SLAP lesions. Conclusions: Our study introduced the novel parameter of the tendon-to-groove ratio of cross-sectional areas as a reproducible parameter for the description of local anatomy in the field of targeted diagnosis of LHB tendon disorders. While our findings do not yet support the predictive value of the tendon-to-groove ratio, they underscore the importance of further research with larger cohorts and control groups to validate these observations.
title: Activité du port de Saint-Malo – 1758 – Nantes
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits exotiques et ultramarins
subject: dopants

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1758 avec le port "Nantes"
description: Marchandises arrivées à Saint-Malo : tabac
description: Catégories de marchandises arrivées à Saint-Malo : produits exotiques et ultramarins ; dopants
description: Coverage: Grand cabotage
description: Bibliographic citation: LE BERRE, Michelle. Les Activités du port de Saint-Malo en 1758. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1048)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Test of Cosmic Web-feeding Model for Star Formation in Galaxy Clusters in the COSMOS Field
Creators: name: Ko, Eunhee
name: Im, Myungshin
name: Lee, Seong-Kook
name: Laigle, Clotilde
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: It is yet to be understood how large-scale environments influence star formation activity in galaxy clusters. One recently proposed mechanism is that galaxy clusters can remain star-forming when fed by infalling groups and star-forming galaxies from large-scale structures surrounding them (the \textit{``web-feeding model"}). Using the COSMOS2020 catalog that has half a million galaxies with high accuracy ($σ_{Δz /1+z} \sim 0.01$) photometric redshifts, we study the relationship between star formation activities in galaxy clusters and their surrounding environment to test the web-feeding model. We first identify $68$ cluster candidates at $0.3 \leq z \leq 1.4$ with halo masses at $10^{13.0} - 10^{14.5}$ \SI{}{M_{\odot}}, and the surrounding large-scale structures (LSSs) with the friends-of-friends algorithm. We find that clusters with low fractions of quiescent galaxies tend to be connected with extended LSSs as expected in the web-feeding model. We also investigated the time evolution of the web-feeding trend using the IllustrisTNG cosmological simulation. Even though no clear correlation between the quiescent galaxy fraction of galaxy clusters and the significance of LSSs around them is found in the simulation, we verify that the quiescent galaxy fractions of infallers such as groups ($M_{200} \geq 10^{12}$ \SI{}{M_{\odot}}) and galaxies ($M_{200} < 10^{12}$ \SI{}{M_{\odot}}) is smaller than the quiescent fraction of cluster members and that infallers can lower the quiescent fraction of clusters. These results imply that cluster-to-cluster variations of quiescent galaxy fraction at $z \leq 1$ can at least partially be explained by feeding materials through cosmic webs to clusters.
description: The Astrophysical Journal, 976:154 (17pp), 2024
Loxodontomys micropus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Loxodontomys
Loxodontomys micropus

description: Loxodontomys micropus (Waterhouse 1837)
[Mus] micropus Waterhouse 1837, Proc. Zool. Soc. Lond., 1837: 17.
Type Locality: Argentina, Santa Cruz Prov., "interior plains of Patagonia" at 50°S latitude, near the Río Santa Cruz (probably near La Argentina as per Hershkovitz, 1962:392).
Vernacular Names: Southern Pericote.
Synonyms: Loxodontomys alsus (Thomas 1919); Loxodontomys fumipes (Osgood 1943).
Distribution: S Andes of Chile and Argentina, from about 38°S latitude to Straits of Magellan.
Conservation: IUCN – Lower Risk (lc) as Auliscomys micropus.
Discussion: Revised by Pearson (1958); banded karyotype published by Spotorno and Walker (1979).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1123, DOI: 10.5281/zenodo.7316535
Attenuation of the BOLD fMRI Signal and Changes in Functional Connectivity Affecting the Whole Brain in Presence of Brain Metastasis
Creators: name: Angstwurm, Pia
name: Hense, Katharina
name: Rosengarth, Katharina
name: Strotzer, Quirin David
name: Schmidt, Nils Ole
name: Bumes, Elisabeth
name: Hau, Peter
name: Pukrop, Tobias
name: Wendl, Christina
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: brainmetastasis; functionalmagnetic resonance imaging; blood oxygenation level-dependent imaging; functional connectivity; percent signal change
subject: 610 Medizin

description: To date, there are almost no investigations addressing functional connectivity (FC) in
patients with brain metastases (BM). In this retrospective study, we investigate the influence of BM
on hemodynamic brain signals derived from functional magnetic resonance imaging (fMRI) and FC.
Motor-fMRI data of 29 patients with BM and 29 matched healthy controls were analyzed to assess
percent signal changes (PSC) in the ROIs motor cortex, premotor cortex, and supplementary motor
cortex and FC in the sensorimotor, default mode, and salience networks using Statistical Parametric
Mapping (SPM12) and marsbar and CONN toolboxes. In the PSC analysis, an attenuation of the
BOLD signal in the metastases-affected hemisphere compared to the contralateral hemisphere was
significant only in the supplementary motor cortex during hand movement. In the FC analysis,
we found alterations in patients’ FC compared to controls in all examined networks, also in the
hemisphere contralateral to the metastasis. This indicates a qualitative attenuation of the BOLD signal
in the affected hemisphere and also that FC is altered by the presence of BM, similarly to what is
known for primary brain tumors. This transformation is not only visible in the infiltrated hemisphere,
but also in the contralateral one, suggesting an influence of BM beyond local damage.