cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Engineering preferentially-aligned nitrogen-vacancy centre ensembles in CVD grown diamond
Creators: name: Osterkamp, Christian
name: Mangold, Martin
name: Lang, Johannes
name: Balasubramanian, Priyadharshini
name: Teraji, Tokuyuki
name: Naydenov, Boris
name: Jelezko, Fedor
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Magnetic properties and materials
subject: Qubits
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Magnetic properties
subject: Magnetic materials
subject: Spintronics
subject: Spintronik

description: Here we report a method for improving the magnetic field sensitivity of an ensemble of Nitrogen- Vacancy (NV) centres in 12C-enriched diamond aligned along the [111] crystal axis. The preferentiallyaligned NV centres are fabricated by a Plasma Enhanced Chemical Vapour Deposition (PECVD) process and their concentration is quantitatively determined by analysing the confocal microscopy images. We further observe that annealing the samples at high temperature (1500 °C) in vacuum leads to a conversion of substitutional nitrogen into NV centres. This treatment also increases the coherence time of the NV centres electron spins up to 40 μs, which corresponds to enhancement of the sensitivity by a factor of three. However, this procedure also leads to a loss of the preferential alignment by 34%.
The space motion of the globular cluster NGC 6397
Creators: name: Kalirai, Jasonjot S.
name: Anderson, Jay
name: Richer, Harvey B.
name: King, Ivan R.
name: Brewer, James P.
name: Carraro, Giovanni
name: Davis, Saul D.
name: Fahlman, Gregory G.
name: Hansen, Brad M.S.
name: Hurley, Jarrod
name: Lépine, Sébastien
name: Reitzel, David B.
name: Rich, R. Michael
name: Shara, Michael M.
name: Stetson, Peter B.
Publisher: name: Swinburne
Year: 2024

description: As a by-product of high-precision, ultradeep stellar photometry in the Galactic globular cluster NGC 6397 with the Hubble Space Telescope, we are able to measure a large population of background galaxies whose images are nearly pointlike. These provide an extragalactic reference frame of unprecedented accuracy, relative to which we measure the most accurate absolute proper motion ever determined for a globular cluster. We find mu(alpha) cos delta = 3.56 +/- 0.04 mas yr(-1) and mu(delta) = -17.34 +/- 0.04 mas yr(-1). We note that the formal statistical errors quoted for the proper motion of NGC 6397 do not include possible unavoidable sources of systematic errors, such as cluster rotation. These are very unlikely to exceed a few percent. We use this new proper motion to calculate NGC 6397's UVW space velocity and its orbit around the Milky Way and find that the cluster has made frequent passages through the Galactic disk.
Supplementary document for Continuous-wave pumped frequency up-conversions in an InSe-integrated microfiber - 5025930.pdf
Creators: name: Hao, Zhen
name: Jiang, Biqiang
name: Hou, Yueguo
name: Li, Chenyang
name: Yi, Ruixuan
name: Ji, Yafei
name: Li, Jiajie
name: Li, Ailun
name: Gan, Xuetao
name: Zhao, Jianlin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Derivation of the relationship between SHG intensity and tangential component of the pump electric field
Educational Care and Play
Giocare con cura.
Creators: name: Bortolotti, Alessandro
name: Ceciliani, Andrea
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: We monitored the relationship between educational care and free play by means of an “ecological observation method” involving more than 90 children aged 3 and 5 years; children were monitored and filmed while playing in the open space (courtyards) of their school. The data we collected were registered by check-list and elaborated statistically; they enabled us to order the observed phenomena according to different levels of analysis, and to carry out a clear comparison between the various school realities at stake. The collected data show a series of situations which can condition children play also in a considerable way, especially in relation to the following parameters: teachers behaviour in relation to conflict and physical danger; children age and gender; use/not use of available tools/toys and spaces. Moving from these parameters, it was possible to point out some actions of ‘educational care’ which can condition children’s free play by enhancing or inhibiting it: play rhapsody; improvisation and divergence; true spontaneity; technical gestures (manipulation) versus natural gestures/actions.
description: L’indagine sul rapporto tra cura educativa ed il gioco motorio spontaneo, si è sviluppata attraverso una metodologia osservativa, di tipo ecologico, che ha coinvolto oltre 90 bambini, di 3 e 5 anni, filmati e osservati durante le attività ludiche svolte negli spazi aperti delle rispettive scuole. Il materiale raccolto, registrato tramite check-list ed elaborato statisticamente, ha consentito di ordinare i fenomeni osservati, secondo diversi piani di analisi, e di impostare un confronto sicuro tra le varie realtà scolastiche investigate. Le risultanze dell’indagine indicano una serie di condizioni in grado di influenzare, anche in modo considerevole, lo svolgersi del gioco motorio, soprattutto rispetto ai seguenti indicatori: atteggiamenti del personale educativo nei confronti dei conflitti e del rischio fisico, età e genere degli allievi, uso/non uso degli attrezzi/giocattoli e degli spazi a disposizione degli allievi. Da tali indicatori è stato possibile individuare alcune azioni di “cura educativa” che possono influenzare, stimolando o inibendo, l’espressione e le forme di gioco motorio, da parte dei bambini: rapsodia ludica, improvvisazione/divergenza, autentica spontaneità, gestualità tecnica (manipolazione) rispetto a motricità naturale.
ROOTS OF RESILIENCE: MYCORRHIZATION AS A KEY PATHWAY TO SUSTAINABLE AGRICULTURE IN HEAT-STRESSED ENVIRONMENTS
Creators: name: Ana Carolina, Silva Pereira
name: Ricardo José, Santos
Publisher: name: continental journal
Year: 2024
Subjects: Climate change, Arbuscular mycorrhizal fungi (AMF), Crop resilience, Soil biology Symbiotic interactions.

description: The escalating impacts of climate change on crop growth and yields, particularly the challenges posed by heat and drought stress, are driving the demand for climate-resilient agricultural technologies and practices. To counteract these adversities and sustain agricultural productivity, a pivotal role is being played by advancements in science and technology. Nature itself has proven proficient in facilitating plant development even in adverse conditions.

Within the intricate web of soil biology and ecosystem interactions, the symbiotic relationship between plant roots and arbuscular mycorrhizal fungi (AMF) emerges as a paramount factor in agriculture. AMF represents a vital group of microorganisms that significantly contribute to the microbial biomass in cultivated soils. Remarkably, around 80% of plant species engage in symbiotic associations with these fungi, underscoring their profound importance in enhancing soil quality and crop performance. Notably, various crops such as beans, soybeans, corn, sunflowers, and wheat exhibit symbiosis with approximately 40 species of arbuscular mycorrhizal fungi. This study delves into the crucial interplay between climate-induced challenges, agricultural sustainability, and the role of AMF symbiosis in mitigating adverse effects.
Inactivation of LACCASE8 and LACCASE5 genes in Brachypodium distachyon leads to severe decrease in lignin content and high increase in saccharification yield without impacting plant integrity
Creators: name: Le Bris, Philippe
name: Wang, Yin
name: Barbereau, Clément
name: Antelme, Sébastien
name: Cézard, Laurent
name: Legée, Frédéric
name: D’Orlando, Angelina
name: Dalmais, Marion
name: Bendahmane, Abdelhafid
name: Schuetz, Mathias
name: Samuels, Lacey
name: Lapierre, Catherine
name: Sibout, Richard
Publisher: name: BioMed Central
Year: 2019

description: Background: Dedicated lignocellulosic feedstock from grass crops for biofuel production is extensively increasing. However, the access to fermentable cell wall sugars by carbohydrate degrading enzymes is impeded by lignins. These complex polymers are made from reactive oxidized monolignols in the cell wall. Little is known about the laccase-mediated oxidation of monolignols in grasses, and inactivation of the monolignol polymerization mechanism might be a strategy to increase the yield of fermentable sugars. Results: LACCASE5 and LACCASE8 are inactivated in a Brachypodium double mutant. Relative to the wild type, the lignin content of extract-free mature culms is decreased by 20–30% and the saccharification yield is increased by 140%. Release of ferulic acid by mild alkaline hydrolysis is also 2.5-fold higher. Interfascicular fibers are mainly affected while integrity of vascular bundles is not impaired. Interestingly, there is no drastic impact of the double mutation on plant growth. Conclusion: This work shows that two Brachypodium laccases with clearly identified orthologs in crops are involved in lignification of this model plant. Lignification in interfascicular fibers and metaxylem cells is partly uncoupled in Brachypodium. Orthologs of these laccases are promising targets for improving grass feedstock for cellulosic biofuel production.
I bambini nelle percezioni delle educatrici.
Children seen through the eyes of teachers in crèches.
Creators: name: Manuzzi, Paola
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il contributo riflette sulle descrizioni delle bambine e dei bambini portate dalle educatrici dei Nidi intervistate, si interroga su loro comportamenti inediti e pone alcune questioni inerenti il difficile incontro fra stili educativi differenti.
description: The essay considers children’s descriptions given by the crèches’ teachers interviewed; it looks into their new behaviours and raises some issues about the tough meeting between different educational styles.
I nidi d’infanzia fra storia e innovazione. Lavoro di cura e scenari istituzionali.
Creches: History and innovation. Providing care and institutional settings
Creators: name: Fabbri, Maurizio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il contributo analizza le connessioni che intercorrono fra il vissuto delle educatrici e i corrispondenti contesti istituzionali
description: The essay focuses on the connections existing between educators’ feelings and the institutional contexts
Il confine educativo e i suoi dintorni.
The Boundaries of Education and the Surrounding Terrain
Creators: name: Leonelli, Silvia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Riconosciuta la polisemia della definizione “cura educativa”, il report ne analizza un singolo frammento: il senso di responsabilità individuale e professionale. Vengono qui presentati in modo narrativo i risultati di una ricerca sulla responsabilità educativa al Nido il cui obiettivo era quello di far emergere significati, modelli e rappresentazioni, nonché aspettative, opinioni e proiezioni, delle persone coinvolte: educatori/educatrici di Nido in servizio da anni e studentesse del terzo anno del Corso di studi in Educatore di Nido e di comunità infantile dell’Università di Bologna. Il confronto tra i due differenti gruppi ha fatto emergere un’interessante dinamica
relativa alla costruzione dell’identità professionale della figura di “educatore/trice di Nido”: il progressivo restringimento dei confini della responsabilità educativa.
description: Having acknowledged the multiple meanings within the definition of “educational cure”, this report will focus on one single section: the sense of individual and professional responsability. This papers shows in a narrated way the outcome of a research on educational responsibility at the Kindergarten, whose objective was that of highlighting meanings, models and representations, but also expectations, opinions and projections of the people involved: Kindergarten female/male educators who have been in duty for years, and females students from the third year of the course called Educatore di Nido e di comunità infantile of Bologna University. The comparison between the two different groups has shown the presence of noteworthy dynamics in the building up of the professional identity of the female/male “kindergarten educator” figure: the progressive decrease in the limits of educational responsability.
The effect of point mutations on the binding affinity of anti-blood group A antibody AC1001.
Creators: name: Thomas, Roula.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Chemistry, Biochemistry.

description: The A and B blood group antigens are very similar, and differ in only one functional chemical moiety; nevertheless this single difference is enough to allow for the recognition of these carbohydrate antigens by their corresponding anti-blood group antibodies. This thesis is focussed on an anti-blood group A (BGA) antibody interaction with its A antigen. A single-chain variable-domain antigen binding fragment (scFv) gene was constructed based on the known sequence of an anti-BGA monoclonal antibody (AC1001), and the protein has been expressed in E. coli. The objective of this work is to improve the binding affinity of this BGA scFv for the A-antigen, and to better understand the mechanisms by which the anti-blood group antibodies can discriminate between the largely similar A and B carbohydrate antigens. The anti-BGA antibody produced in vivo in the immune system does not undergo the process of affinity maturation and somatic mutation because it binds a T cell independent carbohydrate antigen. Therefore, while these anti-carbohydrate IgM antibodies are able to bind their specific antigen, they do so with a very weak binding affinity. We have mimicked the process of affinity maturation and somatic mutation in vitro and attempted to produce a BGA scFv with an increased affinity using two different approaches. (Abstract shortened by UMI.)
Il nido come luogo di mediazione interculturale. Come i modelli educativi e le culture familiari si trasformano nel confronto con i servizi per la prima infanzia.
Day Nurseries as a place of Intercultural Mediation. The transformation of educational models and family  culture in services for the very young.
Creators: name: Bolognesi, Ivana
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il nido, contesto educativo multiculturale, è diventato sempre più un luogo di con-fronto di modelli e pratiche di cura differenti appartenenti ai genitori, italiani e stra-nieri, e alle stesse educatrici. La ricerca, presentata in questo contributo, riporta e-sperienze e riflessioni di donne immigrate che, con la loro testimonianza, dimo-strano l’esistenza di un processo di mediazione tra le culture familiari e la cultura del nido, presente nei servizi da loro frequentati. Dall’analisi delle interviste emergono temi significativi per ripensare l’incontro con i genitori e definire una progettualità capace di contenere al suo interno questioni educative trasversali a tutte le famiglie.
description: Il nido, contesto educativo multiculturale, è diventato sempre più un luogo di con-fronto di modelli e pratiche di cura differenti appartenenti ai genitori, italiani e stra-nieri, e alle stesse educatrici. La ricerca, presentata in questo contributo, riporta e-sperienze e riflessioni di donne immigrate che, con la loro testimonianza, dimo-strano l’esistenza di un processo di mediazione tra le culture familiari e la cultura del nido, presente nei servizi da loro frequentati. Dall’analisi delle interviste emergono temi significativi per ripensare l’incontro con i genitori e definire una progettualità capace di contenere al suo interno questioni educative trasversali a tutte le famiglie.
Dissatisfaction with immigration grows
Creators: name: Betts, Katharine
Publisher: name: Swinburne
Year: 2024

description: Immigration has increased considerably since the late 1990s and between 2004 and 2007 the proportion of voters who want the intake to be reduced rose from 34 per cent to 46 per cent. While support for a reduction was highest in New South Wales, this support was already high in 2004. In relative terms support for a reduction rose most strongly in Victoria. This may be because, over the four-year period, Melbourne absorbed a greater proportion of Australia’s population growth than any other region. Despite growing electoral disquiet, the new Labor Government is increasing the immigration program to record levels.
Supplementary document for Continuous-wave pumped frequency up-conversions in an InSe-integrated microfiber - 5025930.pdf
Creators: name: Hao, Zhen
name: Jiang, Biqiang
name: Hou, Yueguo
name: Li, Chenyang
name: Yi, Ruixuan
name: Ji, Yafei
name: Li, Jiajie
name: Li, Ailun
name: Gan, Xuetao
name: Zhao, Jianlin
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Derivation of the relationship between SHG intensity and tangential component of the pump electric field
La cura nei contesti multiculturali. Le interviste alle educatrici. Analisi di alcuni aspetti dei materiali raccolti.
Care in Multicultural Contexts. Interviews with social workers. The analysis of certain aspects of the material gathered.
Creators: name: Lorenzini, Stefania
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il contributo riferisce aspetti del punto di vista di educatrici in tema di cura e pri-ma infanzia nel nido, contesto educativo multiculturale. I principali interrogativi: se e come cambiano le opinioni delle educatrici quando si tratta di cura in rapporto a bambini e famiglie di origine straniera; se e come si differenziano le difficoltà de-scritte nei rapporti con bambini e famiglie italiane e straniere. Se e in che modo le educatrici ritengono che i bambini al nido possano essere essi stessi soggetti attivi dell’aver cura. Per comprendere alcuni degli aspetti che connotano tali, ampie, questioni le educatrici sono state intervistate dapprima su ciò che, in generale, in-tendono per cura con la prima infanzia, poi su se e cosa cambia in rapporto a bambini di origine straniera e alle loro famiglie. L’analisi è centrata anzitutto sulle risposte di quelle educatrici che per descrivere la propria idea di cura hanno evi-denziato un frequente ricorso ai concetti di attenzione, osservazione, ascolto em-patia, capacità relazionali e disposizione a “entrare nel mondo” del bambino, e anche in quello della famiglia. Mostrando un notevole grado di “consapevolezza profes-sionale”, e anche la presumibile, effettiva, connessione con ciò che concretizzano nel loro operare educativo.
description: Il contributo riferisce aspetti del punto di vista di educatrici in tema di cura e pri-ma infanzia nel nido, contesto educativo multiculturale. I principali interrogativi: se e come cambiano le opinioni delle educatrici quando si tratta di cura in rapporto a bambini e famiglie di origine straniera; se e come si differenziano le difficoltà de-scritte nei rapporti con bambini e famiglie italiane e straniere. Se e in che modo le educatrici ritengono che i bambini al nido possano essere essi stessi soggetti attivi dell’aver cura. Per comprendere alcuni degli aspetti che connotano tali, ampie, questioni le educatrici sono state intervistate dapprima su ciò che, in generale, in-tendono per cura con la prima infanzia, poi su se e cosa cambia in rapporto a bambini di origine straniera e alle loro famiglie. L’analisi è centrata anzitutto sulle risposte di quelle educatrici che per descrivere la propria idea di cura hanno evi-denziato un frequente ricorso ai concetti di attenzione, osservazione, ascolto em-patia, capacità relazionali e disposizione a “entrare nel mondo” del bambino, e anche in quello della famiglia. Mostrando un notevole grado di “consapevolezza profes-sionale”, e anche la presumibile, effettiva, connessione con ciò che concretizzano nel loro operare educativo.
Supplementary document for In vivo test-driven upgrade of a time domain multi-wavelength optical mammograph - 5026073.pdf
Creators: name: Maffeis, Giulia
name: Ferocino, Edoardo
name: Mora, Alberto Dalla
name: Pifferi, Antonio
name: Cubeddu, Rinaldo
name: Taroni, Paola
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary document
Polynômes centraux sur les matrices symétriques.
Creators: name: Boutet, Marie-Claude.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Mathematics.

description: Considérons des polynômes f non-commutatifs à coefficients dans K un corps de caractéristique zéro. Nous construisons une famille de polynômes f n tels que f n évalué sur H n ( K ), les matrices symétriques d'ordre n , prend toutes ses valeurs dans le centre de H n ( K ), c'est-â-dire que ses valeurs sont de la forme α I n , α ∈ K . On se demande s'il existe une évaluation de f n pour laquelle cette valeur est non-nulle. Nous montrons à l'aide de méthodes combinatoires que tel est le cas quand n = 3 ou n = 4.
Mamme e papà attraverso gli occhi delle educatrici. Indagine su reciproche rappresentazioni, problematiche relazionali, conflitti.
Mum and Dad seen through the eyes of crèche assistants. An investigation of reciprocal representations, problem relationships and conflict.
Creators: name: Gigli, Alessandra
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: La ricerca parte dal presupposto che il nido d’infanzia debba configurarsi come uno spazio privilegiato per costruire, attraverso l’azione pedagogicamente orientata, un alleanza educativa tra adulti che hanno a cuore lo sviluppo armonico dei
bambini/e. Affinché questa alleanza si attui autenticamente, e si rinforzi la qualità del lavoro di cura educativa, è utile comprendere e farsi carico della gestione di eventuali problematiche relazionali tra personale educativo e genitori.
La ricerca è stata orientata all’emersione delle rappresentazioni che educatori ed educatrici dei nidi d’infanzia hanno dei cosiddetti “nuovi genitori”, ossia uomini e donne contemporanei portatori di profonde modificazioni socio-cultrali; in particolare
l’obiettivo era portare in luce alcuni pregiudizi e stereotipi in merito alle competenze educative dei genitori e mettere a fuoco anche eventuali problematiche relazionali ed aspetti conflittuali. Oltre alla volontà di capire quanto i fenomeni conflittuali fossero presenti, si è voluto indagare la percezione degli operatori in merito alle problematiche relazionali con i genitori, chiedendosi se fossero in grado di identificarle, se tendessero a negarle, rifiutarle, o farsene carico e gestirle.
description: The research moves from the assumption that the crèche should be a privileged place for building up, through an educational action, an alliance between adults with children’s harmonious development at heart. In order to form this alliance and to give strength to the educational care quality, it wuold be a good idea to understand and take care of the running of possible relational problems between parents and educators. The research has tried to find out educators’ representation of the “new parents”: contemporary men and women who bear deep social and cultural changes. The principal aim was to point out some prejudice and stereotype about parents’ educational capacity and to stress the attention on possible relational problems and aspects marked by conflicts. The research wanted to investigate educators’ perception about relational problems with parents, and to point out if they wuold be able to identify them, if they wuold deny, refuse or handle them.
The strategy of regionalism: Perceptions surrounding United States hegemony in the era of globalization.
Creators: name: Cully, Marie-Hélène.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Political Science, International Law and Relations.

description: This thesis examines the perceptions of American policy-makers of U.S. hegemony. In particular, it looks at the effect globalization on that hegemony and the role that regionalism in the Western hemisphere is expected to play in the future of that hegemony. The thesis first examines the theoretical links in the literature between globalization American hegemony, and regionalism in the Western hemisphere. Once done, this thesis turns to understanding the perceptions of American policy-makers with respect to the perception of a threat to continuing U.S. hegemony. Finally, this thesis exposes the perceptions of American policy-makers as to the nature and role of regionalism as a response to the perceived threat to U.S. hegemony. From this work, we can conclude that the U.S. is potentially employing regionalism as a strategy to offset the perceived threat to its continuing hegemony. This perceived threat can be traced to globalization and its effect on the ability of the U.S. to maintain a preponderant level of control over the factors of hegemony.
Servizi educativi per l’infanzia e contesti familiari. Verso l’alleanza, attraversando la problematicità.
Educational services for very young children and the family context. Moving towards an alliance through problemisation
Creators: name: Contini, Mariagrazia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il contributo, frutto del lavoro di ricerca del Dipartimento di Scienze
dell’educazione, esamina gli aspetti di problematicità emergenti dalle rappresentazioni delle educatrici dei servizi per l'infanzia in relazione ai loro rapporti con le famiglie. I pensieri e le emozioni dei genitori, le loro richieste, i loro giudizi e pregiudizi costituiscono, per le educatrici, nuovi elementi di complessità (e talora di difficoltà) nella costruzione dell'alleanza tra servizi e contesto familiare.
description: The essay focuses on the problematic aspects rising out the educators' representations about their relationships with parents. Parents’ thoughts and emotions, their claims, their opinion and prejudice represent, for the educators, new complex elements (at times some difficulties) in building up an alliance between the services and the familiar context
Supramolecular peptide nanofibrils with optimized sequences and molecular structures for efficient retroviral transduction
Creators: name: Sieste, Stefanie
name: Mack, Thomas
name: Lump, Edina
name: Hayn, Manuel
name: Schütz, Desiree
name: Röcker, Annika
name: Meier, Christoph
name: Kaygisiz, Kübra
name: Kirchhoff, Frank
name: Knowles, Tuomas P. J.
name: Ruggeri, Francesco S.
name: Synatschke, Christopher V.
name: Münch, Jan
name: Weil, Tanja
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: peptide nanofibrils
subject: retroviral gene transfer
subject: DDC 530 / Physics
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 620 / Engineering & allied operations
subject: Self-assembly (Chemistry)
subject: Structure-activity relationships (Biochemistry)
subject: Selbstorganisation

description: Amyloid-like peptide nanofibrils (PNFs) are abundant in nature providing rich bioactivities and playing both functional and pathological roles. The structural features responsible for their unique bioactivities are, however, still elusive. Supramolecular nanostructures are notoriously challenging to optimize, as sequence changes affect self-assembly, fibril morphologies, and biorecognition. Herein, the first sequence optimization of PNFs, derived from the peptide enhancing factor-C (EF-C, QCKIKQIINMWQ), for enhanced retroviral gene transduction via a multiparameter and a multiscale approach is reported. Retroviral gene transfer is the method of choice for the stable delivery of genetic information into cells offering great perspectives for the treatment of genetic disorders. Single fibril imaging, zeta potential, vibrational spectroscopy, and quantitative retroviral transduction assays provide the structure parameters responsible for PNF assembly, fibrils morphology, secondary and quaternary structure, and PNF-virus-cell interactions. Optimized peptide sequences such as the 7-mer, CKFKFQF, have been obtained quantitatively forming supramolecular nanofibrils with high intermolecular β-sheet content that efficiently bind virions and attach to cellular membranes revealing efficient retroviral gene transfer.
Supplementary document for In vivo test-driven upgrade of a time domain multi-wavelength optical mammograph - 5026073.pdf
Creators: name: Maffeis, Giulia
name: Ferocino, Edoardo
name: Mora, Alberto Dalla
name: Pifferi, Antonio
name: Cubeddu, Rinaldo
name: Taroni, Paola
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplementary document
Palladium catalyzed carbon-carbon bond formation at carbon-hydrogen bonds
Creators: name: Campeau, Louis-Charles
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Chemistry, Organic.
subject: Chemistry, Pharmaceutical.

description: The biaryl core has been identified by medicinal chemists as a privileged structure in pharmaceutical compounds as it is found in 4.3% of all drugs. For over a century, synthetic chemists have sought new methods for their preparation. Breakthroughs in synthetic catalytic methodology over the past thirty years gave rise to now routine reactions such as the Suzuki and Stille couplings. Unfortunately, the need for pre-activation of both coupling partners makes for wasteful installation and subsequent removal of activating agents. Direct arylation reactions are attractive alternatives to traditional cross-coupling methods, as one of the pre-activated partners is replaced with a simple arene. The organometallic coupling partner is typically replaced as it is the most difficult to prepare. Although the advantages of this approach have made it a popular research topic for more than twenty-five years, no general catalysts exist for this transformation, and in a lot of cases reactivity remains a challenge. This thesis will outline our work in this area of research. First, our efforts toward the development of a general catalyst for the intramolecular direct arylation of aryl halides with simple arenes will be presented. These studies led to the development of three new catalysts for this transformation, affording a process general for aryl chlorides, bromides and iodides. Additionally, mechanistic studies performed on this system have brought to the forefront the concerted metallation-deprotonation mechanistic model for direct arylation. Ultimately, these studies led to the first non-directed intermolecular direct arylation of a simple arene. In a second section, efforts toward the inclusion of pi-deficient heteocycles as a substrate class in direct arylation will be outlined. These studies led to the development of a novel cross-coupling reaction of azine N-oxides with aryl halides. Greater mechanistic understanding, made possible through the use of computational tools, was crucial in extending this methodology to azole N-oxides. Finally, the development of novel direct functionalization reactions with picoline derivatives is described. These substrates are among the first to be suitable for catalyst controlled site-selective functionalization of a sp2 or sp3 C-H bond.
La cura di chi cura nelle parole delle educatrici di asilo nido.
The Care of Carers- through the words of nursery school teachers
Creators: name: Balduzzi, Lucia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Il presente contributo riporta l’analisi dei risultati di un’indagine empirica sulla percezione del lavoro di cura di insegnanti di asilo nido. Tali pensieri, così come vengono espressi nei focus group e nelle interviste, sono orientati in molteplici direzioni e caratterizzati da intensità e spiegazioni differenti. La percezione del proprio ruolo, lavorativo ed educativo, la relazione con il gruppo di lavoro, con i bambini e con i loro genitori sono alcune tra le tematiche che emergono con maggiore vigore in relazione al complesso tema delle cure in educazione.
description: The current study examines the findings of an empirical research which investigates how the care work in nurseries is perceived by nursery school teachers. The thoughts expressed by these teachers in situation of “focus group” and interviews, are orientated in multiple directions and present various intensities and explanations. Some of the relevant themes that emerged as strongly related to this complex issue of care work in education are: the nursery school teachers’ perception of their own working and educational role and the relationships with the team workers (colleagues), with the children and with the parents.
Pensare la cura.
Thinking about Care.
Creators: name: Manini, Milena
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: Le idee sulla cura delle insegnanti di scuola dell’infanzia e le riflessioni che hanno suscitato sono l’oggetto della presente relazione. Tali pensieri, così come vengono espressi nei focus group e nelle interviste, sono orientati in molteplici direzioni e
caratterizzati da intensità e spiegazioni differenti. I bambini e le bambine in primo luogo e con maggiore frequenza, poi le colleghe, i genitori, se stesse, sono i refe-renti di tali intenzioni dichiarate. Anche il contesto, inteso come intreccio com-plesso formale/informale di spazi, tempi, relazioni interpersonali e rappresenta-zioni di aspettative, desideri, timori, è oggetto di cure. Quando i risultati sono sod-disfacenti e apprezzati, ne diventano anche una fonte, con l’innescarsi di processi positivi di reciprocità.
description: The present study investigates the ideas of care work expressed by infant school teachers and the subsequent reflections generated by these ideas. These thoughts as expressed by the teachers in the focus groups and in the interviews, are orientated in multiple directions and characterised by various intensities and explanations. The themes emerging from their remarks are focused –first and foremost – on the children, then on the colleagues, on the parents and on themselves. Moreover also the context itself – perceived as a complex interaction between formal/informal spaces, times, interpersonal relationships and personal perceptions (expectations, hopes and worries) – is taken into account. The study finds out that, when the outcome of their (infant school teachers) work is satisfactory and recognised, it becomes a reason of motivation, setting off positive reciprocal processes.
Guideline implementation in the Canadian chiropractic setting: a pilot cluster randomized controlled trial and parallel study
Creators: name: Dhopte, Prakash
name: French, Simon
name: Quon, Jeffrey A.
name: Owens, Heather
name: Bussières, André
Publisher: name: BioMed Central
Year: 2019

description: Background: Feasibility and pilot studies are recommended prior to embarking on large-scale costly confirmatory trials. The objectives were to determine the feasibility of conducting a cluster randomized controlled trial (C-RCT) to evaluate a complex knowledge translation (KT) intervention to improve the management of people with neck pain, and to identify challenges and potential solutions to conducting a fully powered C-RCT in the chiropractic setting. Methods: Pilot C-RCT involving a nationally representative sample of chiropractors and patients. We invited 400 chiropractors and 150 patients to participate. Clinicians were randomized to receive either an online theory-based KT educational and brief action plan (BAP) intervention (intervention group) or a copy of a clinical practice guideline (control group). Study-related challenges were ascertained via mid-study phone interviews and end-of-study feedback questionnaires. Analyses focused on descriptive estimates of likely recruitment, retention, and adherence rates, and documentation of potential barriers. Results: In total, 47 chiropractors (12%) agreed to participate and were randomized after resampling. Fifteen withdrew from the study, leaving a total of 32 (8%) participants. Eleven chiropractors in the intervention group completed the webinars and e-learning modules, two partially completed them and three did not register. Participating chiropractors recruited a total of 29 patients. Sixty-three percent (n = 7) of intervention and 56% (n = 10) of control group patients completed all outcome measures at both baseline and 3-months follow-up, attended follow-up visits and performed home exercises. Patients in the intervention group reported significant reductions in pain (mean 1.6, 95% CI 0.26–2.94, P = 0.027) and disability scores (9.8, 95% CI 3.68–15.91, P = 0.033) from baseline to 3-month follow-up. Key barriers to participation reported by chiropractors included lack of time, difficulties in recruiting patients, problems with the administration of study questionnaires, concern that the clinician-patient relationship might be jeopardized, and lack of assistance from office staff. Over half (55%) of the respondents in the intervention group encountered some difficulty registering or completing the educational modules. Conclusion: Recruitment of clinicians and patients for a trial of a complex intervention can be challenging, and retention of participants after enrolment may be low. Future trials of this nature likely require multiple recruitment strategies to achieve desired sample sizes. Moreover, time-constraint issues are perceived particularly by clinicians as a major barrier to both study enrolment before, and protocol adherence during, their actual participation in a trial. Trial registration: The study was registered at, NCT02483091 , on 17th June 2015.
Child care and pre-schools in Sweden: an overview of practice, tendencies and research.
Child care and pre-schools in Sweden: an overview of practice, tendencies and research.
Creators: name: Westling Allodi, Mara
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009

description: L’articolo descrive il sistema dei servizi educativi per la prima infanzia in Svezia, le sue strutture e i suoi obiettivi nel contesto della societá svedese, in relazione al sistema di welfare. Vengono evidenziate alcune tendenze problematiche e difficoltà emergenti, messe in rilievo dalle valutazioni nazionali e dalla ricerca: l’incremento nella variazione della qualità, la più ampia frequenza, la mancanza di insegnanti qualificati, l’interpretazione limitata dei programmi, l’aumento del numero dei bambini identificati come aventi bisogno di sostegno. Vengono anche suggerite alcune interpretazioni che permettono di comprendere le relazioni tra questi fattori.
description: The system and policy for child care and pre-school education in Sweden are overviewed: its structure and goals in the context of the Swedish society and its general welfare system are described. New challenges and actual problematic tendencies revealed by national evaluations and research are identified: the increasing quality variation, the broader attendance, the lack of qualified teachers, a narrowly interpretation of the curriculum, the rising numbers of children identified as having special educational needs. Some interpretations of the relationships among these emerging factors are suggested.
A new approach to overcome shortcomings with multiple testing of reproduction data in ecotoxicology
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015

description: In ecotoxicology species reproduction tests and multiple testing of reproduction data are wide spread. While normal approximation of the data is a minor problem often the requirement of variance homogeneity is not fulfilled. Variance homogeneity is necessary to assure the proper application of statistical procedures like pairwise t tests, Dunnett t test, and Williams t test. A Poisson model can solve this issue preserving meaningful results and rendering statistical analysis more reliable. Moreover, sequential application of pairwise statistical "control vs. treatmentŁ tests is a drawback concerning á-inflation. The closure principle (CP) for hypothesis testing is used to generate a step-wise approach for detection of the No/Lowest Observed Effect Concentration using the computational approach test (CAT). The advantages and disadvantages of the combined CPCAT approach compared to the widely used t tests are pointed out and results of real data and fictitious data analysis are compared revealing the superiority of the Poisson model and CPCAT.Quelle: http://link.springer.com
Life Skill Development in Athletes with Intellectual Disabilities: The Strategies and Learning Pathways of Special Olympics Coaches
Creators: name: Cybulski, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Developmental disabilities
Coaching athletes with intellectual disabilities
Development through sport
Athlete development

description: The purpose of this research was to explore how experienced Special Olympics (SO) coaches attempt to integrate the development of life skills into their coaching practice and how the coaches learned these strategies. Merriam’s (2009) basic interpretive qualitative approach was used to guide this research. Six experienced coaches from Ontario participated in this study. Data were collected through two sets of semi-structured interviews, non-participant observations, and document analysis. Data were analyzed both deductively and inductively using thematic analysis. Camiré, Trudel, and Forneris’s (2012) study on how high school coaches help athletes to develop life skills was used as a framework for life skill development strategies. The analysis uncovered that coaches use the following strategies: (a) having a coaching philosophy aimed at helping athletes to develop, (b) understanding athletes’ pre-existing makeup, (c) providing athletes with opportunities to show their skills, (d) modeling, (e) taking teachable moments, (f) using keywords, and (g) and volunteerism. Two inductive strategies were also found: (a) building strong coach-athlete relationships and (b) being stern and direct with athletes. Trudel, Culver, and Werthner’s 2013 chapter on coach learning was used to frame the learning pathways section of this study. Results from this portion of the study indicate that coaches learned through a variety of different means, including their experiences and through mediated and unmediated learning situations. As one of the first studies to explore the coach’s role in assisting Special Olympics athletes to develop life skills, we feel that this study makes a valuable contribution to the literature on coaching science, sport for people with disabilities, and athlete development. This study also highlights new areas for research that could further expand our knowledge of this topic.
Familial Environment and Overweight/Obese Adolescents’ Physical Activity
Creators: name: Carbert, Nicole S.
name: Brussoni, Mariana
name: Geller, Josie
name: Mâsse, Louise C.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: (1) Background: Family environments can impact obesity risk among adolescents. Little is known about the mechanisms by which parents can influence obesity-related adolescent health behaviours and specifically how parenting practices (e.g., rules or routines) and/or their own health behaviours relate to their adolescent’s behaviours. The primary aim of the study explored, in a sample of overweight/obese adolescents, how parenting practices and/or parental modeling of physical activity (PA) behaviours relate to adolescents’ PA while examining the moderating role of parenting styles and family functioning. (2) Methods: A total of 172 parent-adolescent dyads completed surveys about their PA and wore an accelerometer for eight days to objectively measure PA. Parents completed questionnaires about their family functioning, parenting practices, and styles (authoritative and permissive). Path analysis was used for the analyses. (3) Results: More healthful PA parenting practices and parental modeling of PA were both associated with higher levels of adolescents’ self-reported moderate-vigorous physical activity (MVPA). For accelerometer PA, more healthful PA parenting practices were associated with adolescents’ increased MVPA when parents used a more permissive parenting style. (4) Conclusions: This study suggests that parenting practices and parental modeling play a role in adolescent’s PA. The family’s emotional/relational context also warrants consideration since parenting style moderated these effects. This study emphasizes the importance of incorporating parenting styles into current familial interventions to improve their efficacy.
The method of 3D C-arm navigated AC joint stabilization-surgical technique
Creators: name: Böhringer, Alexander
name: Pankratz, Carlos
name: Eickhoff, Alexander
name: Gebhard, Florian
name: Schütze, Konrad
Publisher: name: Universität Ulm
Year: 2024
Subjects: subject: 3D C-arm imaging
subject: Computer navigation
subject: Shoulder TightRope
subject: AC joint
subject: Tossy
subject: Rockwood
subject: DDC 610 / Medicine & health
subject: Shoulder dislocation; Surgery
subject: Acromioclavicular joint
subject: Surgery, Computer-assisted
subject: Schultergelenkluxation
subject: Akromioklavikulargelenk
subject: Computerassistierte Chirurgie

description: Background: The arthroscopically assisted stabilization of AC joint dislocations with a suture button system is an established procedure that is widely and successfully used in everyday practice. The main advantages of this one-step method are the minimally invasive procedure and the anatomical reconstruction of the ruptured coracoclavicular ligaments with a permanent implant. With this technical note study, for the first time, the new method of navigated suture button implantation in everyday clinical practice is described with the future goal of further reducing invasiveness and increasing precision. Materials and Methods: The surgical technique is explained using precise descriptions and illustrations, photos, X-rays, and 3D reconstructions based on clinical cases. The step-by-step system setup and patient positioning, AC joint reduction and retention, 3D scan and drill tunnel planning, stab incision and Kirschner wire navigation, and cannulated drilling and implant positioning, as well as closure and documentation are described in detail. Results: The standard coracoclavicular stabilization of AC joint dislocations with the 3D C-arm navigated suture button method is described in detail. Furthermore, the feasibility of an additive horizontal acromioclavicular suture cerclage, the implantation of an additional coracoclavicular suture button system, and the single-stage cannulated screw fixation of non-displaced fractures is demonstrated. Conclusion: The navigated suture button method aims to be simple, safe, minimally invasive, and precise. Prospective clinical studies with a long follow-up should be carried out to determine the clinical and radiological outcome in comparison with current methods.