cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Can Movement be Depicted?
Creators: name: Young, Nick
name: Calabi, Clotilde
Publisher: name: Phenomenology and Mind
Year: 2018

description: It is natural to describe many pictures as of movement. We might for example say that a painting is of a horse rearing up, or a dog scurry along the pavement. The topic of this paper is how this “of” should be understood. Can a static picture depict movement, or is movement merely represented by, or suggested by, pictures, in some non-pictorial way? We argue that movement can be depicted and not merely represented. We examine three different views put forward by Le Poidevin, and use his third as a basis for our own view of movement depiction, which is a version of Hopkins’s experienced resemblance theory of depiction.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
The Spatial Experience of Musical Sources: Two Case Studies
Creators: name: Di Bona, Elvira
Publisher: name: Phenomenology and Mind
Year: 2018

description: When listening to specific musical compositions in which physical space is employed with an aesthetic role, we can hear sound sources` spatial properties in the same way as we do it in the case of environmental sound sources. In this essay, I will expand the application of a model for the spatial experience of sound sources to the experience of listening to the musical sound sources of two musical compositions by the Italian composer Luigi Nono. In order to do that, I will briefly summarize how we experience sound sources` spatial properties in the case of environmental sounds; I will then mention the different kinds of physical space which we might be able to hear in the case of musical listening, and I will finally analyze Luigi Nono’s “Hay Que Caminar” Soñando (1989) for two violins and La Lontananza Nostalgica Utopica Futura (1988) for solo violin and 8-track tape to show how the model of the experience of environmental sound sources applies also to these musical cases.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Hierarchical monogamy relations for the squared entanglement of formation in multipartite systems
Creators: name: Bai, Yan-Kui
name: Xu, Yuan-Fei
name: Wang, Z. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show exactly that the squared entanglement of formation (SEF) obeys a set of hierarchical monogamy relations for an arbitrary $N$-qubit mixed state. Based on this set of monogamy relations, we are able to construct the set of hierarchical multipartite entanglement indicators for $N$-qubit states, which still work well even when the concurrence-based indicators lose efficacy. As a by-product, an intriguing analytical relation between the entanglement of formation (EOF) and squared concurrence (SC) for an arbitrary mixed state of $2\otimes d$ systems is derived, making the concurrence calculable via the corresponding EOF. Furthermore, we analyze the multipartite entanglement dynamics in composite cavity-reservoir systems with the present set of hierarchical indicators. Moreover, for multilevel systems, it is illustrated that the SEF can be monogamous even if the SC is polygamous.
description: 12 pages, 6 figures
Survey of the Fragile X Syndrome CGG Repeat and the Short-Tandem-Repeat and Single-Nucleotide-Polymorphism Haplotypes in an African American Population
Creators: name: Schwartz, Charles E.
name: Monaghan, Kristin G.
name: Crawford, Dana C.
name: Howard-Peebles, Patricia N.
name: Feldman, Gerald L.
name: Brown, W. Ted
name: Gunter, Chris
name: Sherman, Stephanie L.
name: Meadows, Kellen L.
name: Rohlfs, Elizabeth M.
name: Carpenter, Nancy J.
name: Warren, Stephen T.
name: Taft, Lisa F.
name: Newman, James L.
name: Reiss, Allan L.
name: Nolin, Sarah L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Previous studies have shown that specific short-tandem-repeat (STR) and single-nucleotide-polymorphism (SNP)–based haplotypes within and among unaffected and fragile X white populations are found to be associated with specific CGG-repeat patterns. It has been hypothesized that these associations result from different mutational mechanisms, possibly influenced by the CGG structure and/or cis-acting factors. Alternatively, haplotype associations may result from the long mutational history of increasing instability. To understand the basis of the mutational process, we examined the CGG-repeat size, three flanking STR markers (DXS548-FRAXAC1-FRAXAC2), and one SNP (ATL1) spanning 150 kb around the CGG repeat in unaffected (n=637) and fragile X (n=63) African American populations and compared them with unaffected (n=721) and fragile X (n=102) white populations. Several important differences were found between the two ethnic groups. First, in contrast to that seen in the white population, no associations were observed among the African American intermediate or “predisposed” alleles (41–60 repeats). Second, two previously undescribed haplotypes accounted for the majority of the African American fragile X population. Third, a putative “protective” haplotype was not found among African Americans, whereas it was found among whites. Fourth, in contrast to that seen in whites, the SNP ATL1 was in linkage equilibrium among African Americans, and it did not add new information to the STR haplotypes. These data indicate that the STR- and SNP-based haplotype associations identified in whites probably reflect the mutational history of the expansion, rather than a mutational mechanism or pathway.
Trumpeting M Dwarfs with CONCH-SHELL: a Catalog of Nearby Cool Host-Stars for Habitable ExopLanets and Life
Creators: name: Gaidos, E.
name: Mann, A. W.
name: Lepine, S.
name: Buccino, A.
name: James, D.
name: Ansdell, M.
name: Petrucci, R.
name: Mauas, P.
name: Hilton, E. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present an all-sky catalog of 2970 nearby ($d \lesssim 50$ pc), bright ($J< 9$) M- or late K-type dwarf stars, 86% of which have been confirmed by spectroscopy. This catalog will be useful for searches for Earth-size and possibly Earth-like planets by future space-based transit missions and ground-based infrared Doppler radial velocity surveys. Stars were selected from the SUPERBLINK proper motion catalog according to absolute magnitudes, spectra, or a combination of reduced proper motions and photometric colors. From our spectra we determined gravity-sensitive indices, and identified and removed 0.2% of these as interloping hotter or evolved stars. Thirteen percent of the stars exhibit H-alpha emission, an indication of stellar magnetic activity and possible youth. The mean metallicity is [Fe/H] = -0.07 with a standard deviation of 0.22 dex, similar to nearby solar-type stars. We determined stellar effective temperatures by least-squares fitting of spectra to model predictions calibrated by fits to stars with established bolometric temperatures, and estimated radii, luminosities, and masses using empirical relations. Six percent of stars with images from integral field spectra are resolved doubles. We inferred the planet population around M dwarfs using $Kepler$ data and applied this to our catalog to predict detections by future exoplanet surveys.
description: Accepted to MNRAS 22 figures, 3 tables, 2 electronic tables. Electronic tables are available as links on this page
Modes of presentation and ways of appearing: a critical revision of Evans’s account*
Creators: name: Sacchi, Elisabetta
Publisher: name: Phenomenology and Mind
Year: 2018

description: There are many ways in which a subject can think about an object. One of these occurs when the subject can perceive the object: perceiving an object makes it possible to think about it in a very direct and straightforward way. This is so because perception of the object makes a subject aware of the object itself. But what is it to be (perceptually) aware of something? Moreover, how does such an awareness have to be accounted for? According to a very influential proposal leading back to Gareth Evans (1982), the kind of awareness that can home a subject’s thought on an object has to be cashed out in terms of singular object-dependent modes of presentation understood as ways of having discriminating (albeit non-descriptive) knowledge of the object. Contra Evans I shall claim that modes of presentation thus characterized do not account for perceptual awareness, but rather presuppose it.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases
Creators: name: Callahan, Leigh F.
name: Wilder, Ronald L.
name: Pincus, Theodore
name: Jawaheer, Damini
name: Amos, Christopher I.
name: Gregersen, Peter K.
name: Kastner, Daniel L.
name: Monteiro, Joanita
name: Kern, Marlene
name: Schroeder, Harry W.
name: Nelson, J. Lee
name: Clegg, Daniel O.
name: Chen, Wei V.
name: Albani, Salvatore
name: Pisetsky, David S.
name: Shigeta, Russell
name: Wener, Mark H.
name: Pope, Richard
name: Flemming, Donald
name: Criswell, Lindsey A.
name: Seldin, Michael F.
name: Ward, Ryk
name: Bridges, S. Louis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex families with RA gathered in the United States. The North American Rheumatoid Arthritis Consortium, using well-defined clinical criteria, has collected 257 families containing 301 affected sibling pairs with RA. A genome screen for allele sharing was performed, using 379 microsatellite markers. A nonparametric analysis using SIBPAL confirmed linkage of the HLA locus to RA (P<.00005), with λHLA=1.79. However, the analysis also revealed a number of non-HLA loci on chromosomes 1 (D1S235), 4 (D4S1647), 12 (D12S373), 16 (D16S403), and 17 (D17S1301), with evidence for linkage at a significance level of P<.005. Analysis of X-linked markers using the MLOD method from ASPEX also suggests linkage to the telomeric marker DXS6807. Stratifying the families into white or seropositive subgroups revealed some additional markers that showed improvement in significance over the full data set. Several of the regions that showed evidence for nominal significance (P<.05) in our data set had previously been implicated in RA (D16S516 and D17S1301) or in other diseases of an autoimmune nature, including systemic lupus erythematosus (D1S235), inflammatory bowel disease (D4S1647, D5S1462, and D16S516), multiple sclerosis (D12S1052), and ankylosing spondylitis (D16S516). Therefore, genes in the HLA complex play a major role in RA susceptibility, but several other regions also contribute significantly to overall genetic risk.
A Founding Locus within the RET Proto-Oncogene May Account for a Large Proportion of Apparently Sporadic Hirschsprung Disease and a Subset of Cases of Sporadic Medullary Thyroid Carcinoma
Creators: name: Williams, Nita
name: Antiñolo, Guillermo
name: López-Alonso, Manuel
name: Wright, Fred A.
name: Fernández, Raquel M.
name: Eng, Charis
name: Borrego, Salud
name: Davuluri, Ramana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Hirschsprung disease (HSCR) is a common congenital disorder characterized by aganglionosis of the gut. The seemingly unrelated multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant disorder characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. Yet, germline mutations in the RET proto-oncogene are associated with both MEN 2 and HSCR. In the former, gain-of-function mutations in a limited set of codons is found, whereas, in the latter, loss-of-function mutations are found. However, germline RET mutation is associated with only 3% of a population-based series of isolated HSCR, and little is known about susceptibility to sporadic MTC. We have found previously that specific haplotypes comprising RET coding single-nucleotide polymorphisms (SNPs) comprising exon 2 SNP A45A were strongly associated with HSCR, whereas haplotypes associated with exon 14 SNP S836S were associated with MTC. In this study, we describe three novel intron 1 SNPs, and, together with the coding SNP haplotypes, the data suggest the presence of distinct ancestral haplotypes for HSCR and sporadic MTC in linkage disequilibrium with a putative founding susceptibility locus/loci. The data are consistent with the presence of a very ancient, low-penetrance founder locus ∼20–30 kb upstream of SNP A45A, but the failure of the SNPs to span the locus presents challenges in modeling mode of transmission or ancestry. We postulate that this founding locus is germane to both isolated HSCR and MTC but also that different mutations in this locus would predispose to one or the other.
STICKELBERGER SERIES AND IWASAWA MAIN CONJECTURE FOR FUNCTION FIELDS
Creators: name: COSCELLI, EDOARDO
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Let F be a global function ?eld in characteristic p>0. There exists many di?erent types of L-functions that can be associated to F, such as the Artin L-functions, the Goss Zeta function or the p-adic L-functions. In this work i have investigated the correlations between these analytic objects and the Stickelberger series, which is a formal power series whose coe?cients lie in a suitable Galois algebra. In the second part of this work i have studied the Iwasawa extension generated by the p-torsion of a Hayes module and i have used the Stickelberger series to prove a "main conjecture" for the p-part of the class group.
Confirmation of the Type 2 Myotonic Dystrophy (CCTG)n Expansion Mutation in Patients with Proximal Myotonic Myopathy/Proximal Myotonic Dystrophy of Different European Origins: A Single Shared Haplotype Indicates an Ancestral Founder Effect
Creators: name: Zhang, Shanxiang
name: Udd, Bjarne
name: Moxley, Richard T.
name: Wright, Fred A.
name: Eymard, Bruno
name: Bottani, Armand
name: Krahe, Ralf
name: Wieser, Thomas
name: Navarro, Carmen
name: Jurkat-Rott, Karin
name: Wessman, Maija
name: Harper, Peter S.
name: Lehmann-Horn, Frank
name: Sallinen, Riitta
name: Gamez, Josep
name: Shriver, Mark D.
name: Sansone, Valeria
name: Rogers, Mark T.
name: Kohler, Andre
name: Bachinski, Linda L.
name: Bassez, Guillaume
name: Meola, Giovanni
name: Thornton, Charles A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Myotonic dystrophy (DM), the most common form of muscular dystrophy in adults, is a clinically and genetically heterogeneous neuromuscular disorder. DM is characterized by autosomal dominant inheritance, muscular dystrophy, myotonia, and multisystem involvement. Type 1 DM (DM1) is caused by a (CTG)n expansion in the 3′ untranslated region of DMPK in 19q13.3. Multiple families, predominantly of German descent and with clinically variable presentation that included proximal myotonic myopathy (PROMM) and type 2 DM (DM2) but without the DM1 mutation, showed linkage to the 3q21 region and were recently shown to segregate a (CCTG)n expansion mutation in intron 1 of ZNF9. Here, we present linkage to 3q21 and mutational confirmation in 17 kindreds of European origin with PROMM and proximal myotonic dystrophy, from geographically distinct populations. All patients have the DM2 (CCTG)n expansion. To study the evolution of this mutation, we constructed a comprehensive physical map of the DM2 region around ZNF9. High-resolution haplotype analysis of disease chromosomes with five microsatellite and 22 single-nucleotide polymorphism markers around the DM2 mutation identified extensive linkage disequilibrium and a single shared haplotype of at least 132 kb among patients from the different populations. With the exception of the (CCTG)n expansion, the available markers indicate that the DM2 haplotype is identical to the most common haplotype in normal individuals. This situation is reminiscent of that seen in DM1. Taken together, these data suggest a single founding mutation in DM2 patients of European origin. We estimate the age of the founding haplotype and of the DM2 (CCTG) expansion mutation to be ∼200–540 generations.
Pooled Analysis of Loss of Heterozygosity in Breast Cancer: a Genome Scan Provides Comparative Evidence for Multiple Tumor Suppressors and Identifies Novel Candidate Regions
Creators: name: Wang, Daolong
name: Miller, Brian J.
name: Krahe, Ralf
name: Wright, Fred A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Somatic loss of heterozygosity (LOH) has been widely reported in breast cancer as a means of identifying putative tumor-suppressor genes. However, individual studies have rarely spanned more than a single chromosome, and the varying criteria used to declare LOH complicate efforts to formally differentiate regions of consistent versus sporadic (random) loss. We report here the compilation of an extensive database from 151 published LOH studies of breast cancer, with summary data from >15,000 tumors and primary allelotypes from >4,300 tumors. Allelic loss was evaluated at 1,168 marker loci, with large variation in the density of informative observations across the genome. Using studies in which primary allelotype information was available, we employed a likelihood-based approach with a formal chromosomal instability and selection model. The approach seeks direct evidence for preferential loss at each locus compared with nearby loci, accounts for heterogeneity across studies, and enables the direct comparison of candidate regions across the genome. Striking preferential loss was observed (in descending order of significance) in specific regions of chromosomes 7q, 16q, 13q, 17p, 8p, 21q, 3p, 18q, 2q, and 19p, as well as other regions, in many cases coinciding with previously identified candidate genes or known fragile sites. Many of these observations were not possible from any single LOH study, and our results suggest that many previously reported LOH results are not systematic or reproducible. Our approach provides a comparative framework for further investigation of regions exhibiting LOH and identifies broad genomic regions for which there exist few data.
Evolution of shear zones in granular materials
Creators: name: Szabo, Balazs
name: Torok, Janos
name: Somfai, Ellak
name: Wegner, Sandra
name: Stannarius, Ralf
name: Bose, Axel
name: Rose, Georg
name: Angenstein, Frank
name: Borzsonyi, Tamas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The evolution of wide shear zones (or shear bands) was investigated experimentally and numerically for quasistatic dry granular flows in split bottom shear cells. We compare the behavior of materials consisting of beads, irregular grains (e.g. sand) and elongated particles. Shearing an initially random sample, the zone width was found to significantly decrease in the first stage of the process. The characteristic shear strain associated with this decrease is about unity and it is systematically increasing with shape anisotropy, i.e. when the grain shape changes from spherical to irregular (e.g. sand) and becomes elongated (pegs). The strongly decreasing tendency of the zone width is followed by a slight increase which is more pronounced for rod like particles than for grains with smaller shape anisotropy (beads or irregular particles). The evolution of the zone width is connected to shear induced density change and for nonspherical particles it also involves grain reorientation effects. The final zone width is significantly smaller for irregular grains than for spherical beads.
description: 11 pages, 12 figures, submitted to Phys. Rev. E
Abilities, freedom, and inputs: a time traveller's tale
Creators: name: Coombes, Olivia
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: time travel
philosophy of time travel
abilities of time travellers
freedom of time travellers
non-time travellers

description: The philosophy of time travel is a sub-field of metaphysics – the study of what there is and what things are like – that considers questions about the possibility of time travel and what a world in which time travel is possible looks like. These questions range from whether time travel is actually possible, to how time travellers can act in the past or future. This thesis delves into a particularly interesting, yet historically undertreated theme: the abilities of time travellers and relatedly their freedom as well. The abilities and freedom of time travellers has been the source of a lot of recent discussion with some polarising views. The minority (which includes Lewis (1976), but also Ted Sider (2002)) argue for the affirmative – that time travellers are free and have the same (or perhaps more) abilities as non-time travellers. The majority (which includes Kadri Vihvelin (1996), Michael Rea (2005), Stephanie Rennick (2015), Alison Fernandes (2020), amongst others) argue for the negative, that time travellers do not have exactly the same freedoms and abilities as non-time travellers. I think that it is a mistake to be so pessimistic about the abilities and freedom of time travellers. I treat concerns about the freedom of time travellers and concerns about the abilities of time travellers as two sides of the same coin. Therefore, in what follows, I argue for two related conclusions. First, I argue that time travellers have all sorts of abilities. Second, I argue that time travellers are just as free as non-time travellers. In arguing for these conclusions, I first produce a novel analysis of ability which reveals important details about how abilities track inputs rather than outputs. Second, I use this new analysis of ability to present a new compatibilist account of free will. If I am right in arguing positively for the abilities and freedoms of time travellers, then this has large implications for both the current time travel discourse and the general debate surrounding freedom. Significantly, I am arguing against some prominent views about time travel and in suggesting that these views are mistaken, I am presenting new ideas about ability and freedom: specifically, that time travellers have the ability and are free to do impossible things.
title: Особенности технологии производства цукатов из кабачков
Creators: name: Глебова, Ольга
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье представлены особенности производства цукатов из кабачков. Растительная пища в жизни человека имеет большое значение. Из нее в организм попадают углеводы, витамины и макро- и микроэлементы. Также за счет ароматических и вкусовых веществ она лучше усваивается. В свежем виде овощи имеют короткий срок хранения из-за пагубного воздействия окружающей среды, т. е. порчи со стороны микроорганизмов.
Поэтому для приготовления цукатов из кабачков для длительного хранения их следует перерабатывать в кратчайшие сроки. В питании и образе жизни сейчас главенствует тенденция «health & wellness» – «здоровье и здоровое питание». В связи с этим потребители стали обращать все большее внимание на «правильные» продукты, которые приносят пользу организму.
The Gardner transition in finite dimensions
Creators: name: Urbani, Pierfrancesco
name: Biroli, Giulio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Recent works on hard spheres in the limit of infinite dimensions revealed that glass states, envisioned as meta-basins in configuration space, can break up in a multitude of separate basins at low enough temperature or high enough pressure, leading to the emergence of new kinds of soft-modes and unusual properties. In this paper we study by perturbative renormalisation group techniques the critical properties of this transition, which has been discovered in disordered mean-field models in the '80s. We find that the upper critical dimension $d_u$ above which mean-field results hold is strictly larger than six and apparently non-universal, i.e. system dependent. Below $d_u$, we do not find any perturbative attractive fixed point (except for a tiny region of the 1RSB breaking parameter), thus showing that the transition in three dimensions either is governed by a non-perturbative fixed point unrelated to the Gaussian mean-field one or becomes first order or does not exist. We also discuss possible relationships with the behavior of spin glasses in a field.
description: 5 pages, 2 figures
Functionalization of Oxide‐Free Silicon Surfaces for Biosensing Applications
Creators: name: Henriksson, Anders
name: Neubauer, Peter
name: Birkholz, Mario
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
subject: biofunctionalization
subject: biosensors
subject: hydrosilylation
subject: oxide-free silicon surface
subject: self-assembled monolayers
subject: silicon passivation
subject: silicon surfaces

description: As an alternative to standard silicon biofunctionalization protocol based on alkoxysilanes that bind to SiO2 on oxidized silicon substrates, several protocols to form bifunctional interlayers that directly bind to the silicon surface via a strong Si—C bond have been developed during the last decades. These interlayers are more stable, and the lack of an insulating layer between the substrate and the interlayer reduces electric noise in biosensor devices. Si—C monolayers are not yet regularly applied as the protocols are more complex and generally require an inert gas atmosphere. However, a variety of applications and new methods to form bifunctional Si—C interlayers are recently developed. Here, the role these innovative protocols and interlayers play in biofunctionalization of silicon surfaces is reviewed and their applications in electrochemical, microelectromechanical, and optical biosensing are reported. From the analysis of the current situation, it can be concluded that the advantageous properties offered with this approach in many cases more than outweigh the additional processes to form Si—C bonded interlayers and the approach is predicted to expand the applications of future silicon-based biosensors.
Tomography by noise
Creators: name: Harder, G.
name: Mogilevtsev, D.
name: Korolkova, N.
name: Silberhorn, Ch.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present an efficient and robust method for the reconstruction of photon number distributions by using solely thermal noise as a probe. The method uses a minimal number of pre-calibrated quantum devices, only one on/off single-photon detector is sufficient. Feasibility of the method is demonstrated by the experimental inference of single-photon, thermal and two-photon states. The method is stable to experimental imperfections and provides a direct, user-friendly quantum diagnostics tool.
Variation in a Repeat Sequence Determines Whether a Common Variant of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Is Pathogenic or Benign
Creators: name: Estivill, Xavier
name: Schwartz, Marianne
name: Kanavakis, Emmanuel
name: Stuhrmann, Manfred
name: Pignatti, Pier Franco
name: D’Apice, Maria Rosaria
name: Bombieri, Cristina
name: Guittard, Caroline
name: Des Georges, Marie
name: Sobczynska-Tomaszewska, Agnieszka
name: Tzetis, Maria
name: Cutting, Garry R.
name: Nemeth, Krisztina
name: Fekete, Gyorgy
name: Fallin, M. Daniele
name: Casals, Teresa
name: Claustres, Mireille
name: Bassas, Lluís
name: Novelli, Giuseppe
name: Koudova, Monika
name: Macek, Milan
name: Kadasi, Ludovit
name: Friedman, Ken
name: Groman, Joshua D.
name: Hefferon, Timothy W.
name: Bal, Jerzy
name: Schwarz, Martin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: An abbreviated tract of five thymidines (5T) in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is found in ∼10% of individuals in the general population. When found in trans with a severe CFTR mutation, 5T can result in male infertility, nonclassic cystic fibrosis, or a normal phenotype. To test whether the number of TG repeats adjacent to 5T influences disease penetrance, we determined TG repeat number in 98 patients with male infertility due to congenital absence of the vas deferens, 9 patients with nonclassic CF, and 27 unaffected individuals (fertile men). Each of the individuals in this study had a severe CFTR mutation on one CFTR gene and 5T on the other. Of the unaffected individuals, 78% (21 of 27) had 5T adjacent to 11 TG repeats, compared with 9% (10 of 107) of affected individuals. Conversely, 91% (97 of 107) of affected individuals had 12 or 13 TG repeats, versus only 22% (6 of 27) of unaffected individuals (P<.00001). Those individuals with 5T adjacent to either 12 or 13 TG repeats were substantially more likely to exhibit an abnormal phenotype than those with 5T adjacent to 11 TG repeats (odds ratio 34.0, 95% CI 11.1–103.7, P<.00001). Thus, determination of TG repeat number will allow for more accurate prediction of benign versus pathogenic 5T alleles.
A Powerful and Robust Method for Mapping Quantitative Trait Loci in General Pedigrees
Creators: name: Diao, G.
name: Lin, D.Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The variance-components model is the method of choice for mapping quantitative trait loci in general human pedigrees. This model assumes normally distributed trait values and includes a major gene effect, random polygenic and environmental effects, and covariate effects. Violation of the normality assumption has detrimental effects on the type I error and power. One possible way of achieving normality is to transform trait values. The true transformation is unknown in practice, and different transformations may yield conflicting results. In addition, the commonly used transformations are ineffective in dealing with outlying trait values. We propose a novel extension of the variance-components model that allows the true transformation function to be completely unspecified. We present efficient likelihood-based procedures to estimate variance components and to test for genetic linkage. Simulation studies demonstrated that the new method is as powerful as the existing variance-components methods when the normality assumption holds; when the normality assumption fails, the new method still provides accurate control of type I error and is substantially more powerful than the existing methods. We performed a genomewide scan of monoamine oxidase B for the Collaborative Study on the Genetics of Alcoholism. In that study, the results that are based on the existing variance-components method changed dramatically when three outlying trait values were excluded from the analysis, whereas our method yielded essentially the same answers with or without those three outliers. The computer program that implements the new method is freely available.
title: Response of common ragweed (Ambrosia artemisiifolia L.) to soil salinity
Creators: name: Leskovšek, Robert
name: Simončič, Andrej
Publisher: name: Julius Kühn-Institut
Year: 2016

description: Julius-Kühn-Archiv, Nr. 455 (2016): HALT Ambrosia - final project report and general publication of project findings
Molecular and Clinical Analyses of Greig Cephalopolysyndactyly and Pallister-Hall Syndromes: Robust Phenotype Prediction from the Type and Position of GLI3 Mutations
Creators: name: Johnston, Jennifer J.
name: Peters, Kathryn F.
name: Holmes, Lewis B.
name: Aughton, David J.
name: Mazzanti, Laura
name: Leppig, Kathleen A.
name: David, Albert
name: MacLeod, Patrick
name: Curry, Cynthia J.
name: McCann, Emma
name: McDonald, Marie T.
name: Graham, John M.
name: Grange, Dorothy K.
name: Hannibal, Mark C.
name: Killoran, Christina
name: Booth, Carol
name: Abbott, Margaret H.
name: Lin, Angela E.
name: Flannery, David B.
name: Marcelis, Carlo
name: Dinulos, Mary Beth
name: Turner, Joyce T.
name: Bamshad, Michael J.
name: Hennekam, RaoulC.M.
name: Manchester, David K.
name: Aylsworth, Arthur S.
name: Fox, Michelle A.
name: Olivos-Glander, Isabelle
name: Hoyme, H. Eugene
name: Guttmacher, Alan E.
name: Elson, Emma
name: Henn, Wolfram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Mutations in the GLI3 zinc-finger transcription factor gene cause Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS), which are variable but distinct clinical entities. We hypothesized that GLI3 mutations that predict a truncated functional repressor protein cause PHS and that functional haploinsufficiency of GLI3 causes GCPS. To test these hypotheses, we screened patients with PHS and GCPS for GLI3 mutations. The patient group consisted of 135 individuals: 89 patients with GCPS and 46 patients with PHS. We detected 47 pathological mutations (among 60 probands); when these were combined with previously published mutations, two genotype-phenotype correlations were evident. First, GCPS was caused by many types of alterations, including translocations, large deletions, exonic deletions and duplications, small in-frame deletions, and missense, frameshift/nonsense, and splicing mutations. In contrast, PHS was caused only by frameshift/nonsense and splicing mutations. Second, among the frameshift/nonsense mutations, there was a clear genotype-phenotype correlation. Mutations in the first third of the gene (from open reading frame [ORF] nucleotides [nt] 1–1997) caused GCPS, and mutations in the second third of the gene (from ORF nt 1998–3481) caused primarily PHS. Surprisingly, there were 12 mutations in patients with GCPS in the 3′ third of the gene (after ORF nt 3481), and no patients with PHS had mutations in this region. These results demonstrate a robust correlation of genotype and phenotype for GLI3 mutations and strongly support the hypothesis that these two allelic disorders have distinct modes of pathogenesis.
Tricellulin Is a Tight-Junction Protein Necessary for Hearing
Creators: name: Fanning, Alan S.
name: Riazuddin, Saima
name: Forge, Andrew
name: Riazuddin, Sheikh
name: Khan, Shaheen N.
name: Ramzan, Khushnooda
name: Kitajiri, Shin-ichiro
name: Ahmed, Zubair M.
name: Friedman, Thomas B.
name: Chattaraj, Parna
name: Anderson, James M.
name: Belyantseva, Inna A.
name: Lagziel, Ayala
name: Friedman, Penelope L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The inner ear has fluid-filled compartments of different ionic compositions, including the endolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure and function of tricellular contacts of neighboring cells in many epithelial tissues. We show that, in humans, four different recessive mutations of TRIC cause nonsyndromic deafness (DFNB49), a surprisingly limited phenotype, given the widespread tissue distribution of tricellulin in epithelial cells. In the inner ear, tricellulin is concentrated at the tricellular TJs in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells. We also demonstrate that there are multiple alternatively spliced isoforms of TRIC in various tissues and that mutations of TRIC associated with hearing loss remove all or most of a conserved region in the cytosolic domain that binds to the cytosolic scaffolding protein ZO-1. A wild-type isoform of tricellulin, which lacks this conserved region, is unaffected by the mutant alleles and is hypothesized to be sufficient for structural and functional integrity of epithelial barriers outside the inner ear.
À descoberta da Ria Formosa com o Ciencia Viva no Verão em rede
Creators: name: Santos, Ana Luísa
name: Antunes, Ana Paula
name: Reis, Emanuel
Publisher: name: Zenodo
Year: 2016

description: No âmbito da edição de 2015 do programa Ciência Viva no Verão em Rede, o Centro Ciência Viva do Algarve dinamizou as ações Biodiversidade — Desafios e ameaças numa Ria em mudança e À descoberta dos fundos da Ria Formosa por snorkeling usando como base uma sala desocupada no Centro Náutico da Praia de Faro. Situado em plena "Ilha de Faro", uma extensão de areia que na realidade faz parte da Península do Ancão e que delimita a parte poente da Ria Formosa, o Centro Náutico da Praia de Faro tem uma localização estratégica junto à praia interna na laguna e a pouca distância da praia da costa atlântica. Desta forma foi possível realizar atividades não só no interior das instalações do Centro Náutico, mas também e em virtude de autorização dada pela Capitania do Porto de Faro, tanto na zona lagunar (Ria Formosa) como na zona marítima. As ações desenvolvidas abrangeram: i) a instalação de uma exposição interativa na sala do Centro Náutico, na qual se incluía um "apalpário" móvel (pequeno aquário representativo dos fundos marinhos, intertidal e poças de maré da Ria Formosa, onde, como o seu próprio nome indica, se podem "apalpar" os organismos presentes) e ii) a dinamização de atividades lúdico-pedagógicas no interior dessa sala bem como na zona intertidal lagunar e no areal marítimo (sessões de snorkeling, atividades de recolha de lixo, etc). Pretendeu-se através destas ações dar a conhecer e evidenciar aos veraneantes que acorrem em grande número às praias na parte atlântica da península do Ancão, a enorme beleza, sensibilidade e importância ecológica, social e económica da Ria Formosa bem como promover a sua preservação. Estas ações permitiram contrariar um pouco a tendência que os visitantes têm, durante o período balnear, de estar literalmente de costas voltadas para este tesouro natural que é a Ria Formosa.
title: Downward Real Earnings Management around Operating Activities: Evidence from the UK
titleType: Other
Creators: name: Yaaqbeh, Mohammad
Publisher: name: University of Dundee
Year: 2022

description: This thesis builds on agency theory and income smoothing hypothesis to link two lines of earnings management research, which are: (i) downward earnings management, and (ii) real earnings management (REM). Although earnings management is a well-researched area in the literature, downward REM around operating activities is widely overlooked.

Based on that, and using a large sample of UK listed firms over the period of 2010-2019, this thesis aims at investigating four main research questions, being: (i) to what extent do suspect UK listed firms engage in downward REM techniques around operating activities? (RQ1); (ii) what is the timing during the financial year in which downward REM techniques take place? (RQ2); (iii) what is the nature of the relationship between REM and accrual earnings management (AEM) in context of this thesis? (RQ3); and (iv) what is the impact of audit quality on these downward REM attempts? (RQ4).

To address these research questions, an ex-ante approach based on the theoretical framework adopted in the current thesis has been used in identifying suspect observations. That is, firms that out-perform in the first half of their financial years are considered as suspect observations. This is identified based on the percentage of change in the first half-year earnings of two consecutive years.

The results around the aforementioned research questions have been reported in two empirical chapters. While the first empirical chapter addresses the first two research questions, the second empirical chapter addresses the last two research questions

The findings of the first empirical chapter revealed that downward REM existed around suspect firms in the context of this thesis. In detail, the findings indicate that suspect firms engaged in managing production levels by under-producing and managing cash flow from operations (CFO) to pull their earnings down. However, this was less evident around discretionary expenses as a downward REM tool (RQ1). Additionally, the findings of this chapter also provided evidence of the timing of earnings management techniques being attempted towards the year end, namely in the second half of the financial year (RQ2).

Moreover, the findings of the second empirical chapter provided a new evidence based on a UK-based income-decreasing context of the substitutive relationship between real and accrual earnings management (RQ3). The findings of this chapter also indicted that high-quality audit is not effective in constraining all forms of earnings management tools in the context of this thesis (RQ4).

Finally, these findings proved to be robust to a number of robustness and sensitivity tests.
"fnl1014_I902309.tab.gz" of "Measurement of the Inclusive Jet Cross Section in pp Collisions at sqrt(s) = 7 TeV"
Creators: name: CMS Collaboration
Publisher: name: HEPData
Year: 2011

description: Link to fastNLO v2.1 table
description: CERN-LHC. Measurement of the double differential cross sections for inclusive jet production in proton-proton collisions at a centre-of-mass energy of 7 TeV. The data sample has a total integrated luminosity of 34 pb-1 and covers the jet transverse momentum range from 18 to 1100 GeV and |rapidity| values < 3. As well as the data points this records also tabulates the multiplicative corrections to be applied to NLO theory predictions.
ทัศนคติของผู้บริโภคที่มีต่อกลยุทธ์การสื่อสารทางการตลาดของผลิตภัณฑ์บำรุงผิวผ่านแอปพลิเคชันติ๊กต๊อก
Creators: name: ศิริภัทร สิตไทย
Publisher: name: คณะนิเทศศาสตร์ มหาวิทยาลัยราชภัฏรำไพพรรณี
Year: 2566
Subjects: ทัศนคติของผู้บริโภค
การสื่อสารทางการตลาด
แอปพลิเคชันติ๊กต๊อก

description: วารสารนวัตกรรมสังคมและเทคโนโลยีสื่อสารมวลชน, 6, 2, 62-74
"fnl1014_cv21_I902309.tab.gz" of "Measurement of the Inclusive Jet Cross Section in pp Collisions at sqrt(s) = 7 TeV"
Creators: name: CMS Collaboration
Publisher: name: HEPData
Year: 2011

description: Link to fastNLO v2.1 table (converted from v1.4 format)
description: CERN-LHC. Measurement of the double differential cross sections for inclusive jet production in proton-proton collisions at a centre-of-mass energy of 7 TeV. The data sample has a total integrated luminosity of 34 pb-1 and covers the jet transverse momentum range from 18 to 1100 GeV and |rapidity| values < 3. As well as the data points this records also tabulates the multiplicative corrections to be applied to NLO theory predictions.
title: Разработка нового сахаристого кондитерского изделия «Черная смородина в сахарной пудре»
Creators: name: Глебова, Ольга
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Известно, что продукт «Клюква в сахаре» в Великом Новгороде уже долгое время продается как сувенирная продукция. Туризм в Великом Новгороде является одним из наиболее перспективных направлений развития городской экономики. Черная смородина – многолетнее растение семейства крыжовниковых. Ягоды черной смородины являются низкокалорийными. Черная смородина считается кладезем полезных веществ и
витаминов. По технологической схеме продукта «Клюква в сахаре» в производственных условиях перерабатывающего сбытового сельскохозяйственного потребительского кооператива «Дары Святогории» были произведены опытные образцы продукта «Черная смородина в сахарной пудре». Предприятие заинтересовано в расширении ассортимента, с целью поддержания Новгородских традиций и развития гастрономического бренда
Великого Новгорода.
ESDH-system
Creators: Lejre Kommune
Publisher: name: Rigsarkivet
Year: 2023

description: At skabe et fælles sag- og arkivsystem for Lejre Kommune, med henblik på effektiv sagsbehandling, videndeling og genfinding af sager.
Der er digitale metadata for hele perioden og digitale dokumenter fra 1.1.2014 - 31.12.2019
"ins915978" of "Measurement of the Cross Section for Prompt Isolated Diphoton Production in p\bar p Collisions at \sqrt{s} = 1.96 TeV"
Creators: name: CDF Collaboration
Publisher: name: HEPData
Year: 2013

description: ==> link to data tables
description: Data tables can be found in the article PR D84, 052006 (2011); see https://hepdata.net/record/ins915978 .
Grain Mineral Concentrations in Maize (Zea Mays L.) and Nutrient Use Efficiency as Affected by Fertilizer Management on a Nitisol in Southwestern Ethiopia
Creators: name: Zerssa, Gebeyanesh Worku
name: Kim, Dong-Gill
name: Koal, Philipp
name: Eichler-Löbermann, Bettina
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: The combined application of organic and mineral fertilizers is an appropriate agronomic measure and is particularly important for smallholders who have limited access to mineral fertilizers. However, fertilizer recommendations in terms of crop nutritional value and nutrient efficiency strongly vary in dependence of site-specific conditions. In this study, seven different ratios of bio-waste compost (comp) and mineral fertilizers (MF), consisting of nitrogen (N), phosphorus (P), and sulfur (S), were tested in a two-year field experiment on a Nitisol soil in order to assess their effects on nutritionally important minerals in maize (Zea mays, L. Bako-hybrid) grains as well as the nutrient use efficiency. The application of fertilizers corresponded to an N supply of about 100 kg ha−1, whereby the application of only MF (100 MF) was gradually replaced by compost. Compared to 100 MF the treatments with 40 to 70% of N supply given with compost had a higher concentration of most grain minerals. The most pronounced elevations were found for Fe (570 vs. 304 mg kg‒1) and Mn (70.1 vs. 36.3 mg kg‒1) when 50% of the N was given with compost in comparison to the 100 MF treatment. The P use efficiency increased particularly when compost was part of the nutrient supply. The results suggest that replacing mineral fertilizer with compost accounting for 40 to 70% of the total N supply would be a suitable option for increasing the nutritional quality of maize grains and to efficiently use fertilizers on this Nitisol.
Assessment on the Status of CyberSecurity in Denmark
Creators: IT University of Copenhagen
Syddansk Universitet
Oksana Kulyk
Jacopo Mauro
Publisher: name: Rigsarkivet
Year: 2023

description: The project aims to study and report on the existing cybersecurity and privacy protection practices used in large Danish companies and SMEs, identifying the most important challenges the developers in Denmark face in developing secure and privacy-preserving solutions, and providing guidelines for securing critical infrastructures
eKapital - delsystemet vedr. renteoplysninger
Creators: Skatteforvaltningen
Publisher: name: Rigsarkivet
Year: 2023

description: Systemets formål er at indsamle og registrere oplysninger vedrørende skatteyderes indkomster. Oplysningerne  anvendes til dannelse af en korrekt årsopgørelse for skatteyderen, samt til at kontrollere at de oplysninger, skatteyderen indberetter, er korrekte. Systemets data anvendes herudover til sagsbehandling vedrørende  de dannede årsopgørelser og de modtagne kontroloplysninger. Dette sker i sagsbehandlersystemet Skatteoplysninger (R75). Bemærk at RKO ikke rummer oplysninger vedrørende alle de forskellige indkomsttyper en skatteyder kan have.