cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Tetramorium xanthogaster Santschi, stat. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium xanthogaster

description: Tetramorium xanthogaster Santschi stat. n.
(Figs 3, 4)
Tetramorium (Xyphomyrmex) [sic] sikorae st. xantogaster [sic] Santschi, 1911: 124. Holotype worker, Madagascar {J. de Gaulle) (NM, Basle) [examined]. Xiphomyrmex sikorae subsp. xanthogaster Santschi; Wheeler, 1922: 1032. Emery, 1922: 287 [justified emendation].
Worker. TL 3.2, HL 0.76, HW 0.66, CI 89, SL 0.54, SI 82, PW 0.50, AL 0.88.
Mandibles smooth with scattered small pits. Median clypeal carina very faint, almost effaced, much less distinct than the lateral carinae. Frontal carinae very reduced, their posterior extensions fine and no more distinct than the rugulae between them. Antennal scrobes absent. Metanotal groove not impressed. Propodeum armed with a pair of short, stout spines, the metapleural lobes roughly triangular. Dorsum of head with very fine, faint, irregular longitudinal rugulae and with a superficial reticulate ground sculpture between them. Dorsal alitrunk with scattered, weak, predominantly longitudinal rugulae. Pedicel and gaster unsculptured, smooth and polished. All dorsal surfaces of head and body with erect or suberect fine hairs. Head and alitrunk dark brown, pedicel and gaster clear pale yellow, the two strongly contrasting.
As Santschi pointed out in the original description, this small species is close to sikorae, but unlike that species it is bicoloured, has relatively longer antennal scapes, lacks scrobes and has much better developed propodeal spines. The presence of gastral pilosity places this species in the sikorae-complex of the schaufussi-group, but the characters given above will quickly separate xanthogaster from its allies.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 139
Contribution of myeloid cells to bevacizumab evasion in glioblastoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The prognosis for patients with glioblastoma is quite poor, with a median survival of 12 to 15 months after aggressive surgical resection followed by radiation therapy and chemotherapy, unchanged over the past decade. Several studies have investigated anti-angiogenic therapy of glioblastoma, with phase II clinical trials of vascular endothelial growth factor (VEGF) neutralizing antibody bevacizumab producing encouraging results. Unfortunately, many glioblastomas progress radiographically after initially responding to bevacizumab. The prognosis of patients after the development of bevacizumab evasion is extremely poor, with no effective chemotherapy and surgery challenging due to the infiltrative nature of tumor growth that occurs as part of the adaptive response to anti-angiogenic therapy. Thus, understanding the mechanisms of evasion to anti-angiogenic therapy will be vital in order to allow these therapies to achieve their full potential. The hypothesis that will be investigated in this one year CRCC proposal is that infiltration of bone marrow-derived leukocytes is central to the myriad of changes that have been found in tumors evading anti-angiogenic therapy. This hypothesis will be confirmed through the following specific aims. First, we will investigate the time course and regulatory factors involved in the myeloid cell infiltration seen after VEGF blockade in glioblastoma. Second, we will determine the impact of myeloid cells on glioblastoma growth during VEGF blockade. Third, we will determine the impact of myeloid cells on glioblastoma growth during VEGF blockade. Understanding the role of myeloid cells in the adaptive response to anti-angiogenic therapy in glioblastoma will have tremendous implications in our understanding of the biology of and treatment of glioblastomas, as well as other malignant cancers.
Additional file 3: of Trade-offs in the production of animal vocal sequences: insights from the structure of wild chimpanzee pant hoots
Creators: name: Fedurek, Pawel
name: Zuberbühler, Klaus
name: Semple, Stuart
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Calculation of the dominance status of the study males. (DOCX 107 kb)
Development of methods for the preparation of new anticancer agents
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In the treatment of cancer, chemotherapy has established a prominent position. The development of drugs that became remarkably effective in the treatment of cancer has been influenced significantly by natural products chemistry. Natural products have inspired the discovery and development of many successful therapies against cancer (Taxol is one example), and efficiency with which they are produced (reflected, for example, in production costs) parallels broader progress in synthetic organic chemistry. In addition, an important, yet often overlooked benefit is the training of students who subsequently find employment in pharmaceutical companies, many of which are vital in bringing new ideas for the development of drugs and therapies against cancer. The research in this proposal is aimed at the synthesis of a new marine anticancer natural product sintokamide A. Sintokamide A is one of new chlorinated peptides isolated from the marine sponge Dysidea sp. by the group of R. J. Andersen. The natural product has been shown to be an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells, providing a new direction in the treatment of castration recurrent prostate cancer with small-molecule drugs. From the perspective of organic synthesis, a major goal in the synthesis of compounds such as sintokamides will be the preparation of haloleucine amino acid derivatives. A number of other bioactive marine natural products incorporate haloleucine fragments. Currently, there are no straightforward methods available for the stereoselective synthesis of these structures, and, consequently, one of the major objectives of this application is the development of such methods. Once the synthesis of virtually unavailable from natural sources sintokamide A is completed, we will carry out a detailed study to define the mode of action of sintokamide A in collaboration with Professor John Koh, an Associate Director of Delaware Biotechnology Institute at the University of Delaware, whose group has more than a decade of experience with androgen receptors.
Activity detection in scientific visualization
Creators: name: Ozer, Sedat
Publisher: name: No Publisher Supplied
Year: 2013

description: Today’s state of the art simulations generate high-resolution data at an ever-increasing rate. Such simulations produce data with billions of mesh points (or voxels) for each timestep and thousands of such timesteps with multiple variables. Time-varying data can easily reach peta- and exa-byte scale. Visualizing these massive data sets is still an on-going problem. Even after visualizing this data, viewing each variable at each timestep is practically impossible when there are thousands of timesteps. Simulations become too complex for the scientist to analyze manually. In such time-varying data sets, scientists want to know “where and when events happen” or “how long an event lasts”. Finding these events in thousands of timesteps is not possible with standard visualization tools. What scientists need are routines, procedures and visualizing techniques to help filter massive data and help focus on areas and events of interest automatically.  The problems facing any attempt to localize complex events (activities) automatically in time-varying 3D scientific data can be summarized as: (1) provide an appropriate way for users to define an event of interest; (2) find an appropriate formalism to model this event; (3) apply the model to detect many instances of the event of interest in simulation data; and (4) present the detected events to users in an appropriate visual form.  The contributions in this dissertation include introduction of the concept of activity detection for scientific visualization, the use of Petri Nets to model and detect activities in scientific visualization, an enhancement of Petri Nets to include the dynamics of scientific phenomena and demonstration of the use of activity detection on three different 3D time-varying data sets as case studies. In addition, a full 3D group-tracking model in which we extract and track groups as well as the individual features that form them is presented.
Additional file 4: of Trade-offs in the production of animal vocal sequences: insights from the structure of wild chimpanzee pant hoots
Creators: name: Fedurek, Pawel
name: Zuberbühler, Klaus
name: Semple, Stuart
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Table with the type of variable transformation in models concerning the relationship between call duration and the investigated (fixed) variables in the introduction, build-up, climax, let-down, and the entire sequence. (DOCX 47 kb)
Design and implementation of distributed mobile computing platform using Hadoop
Creators: name: Pandhe, Shraddha
Publisher: name: No Publisher Supplied
Year: 2013

description: This thesis is aimed at design and evaluation of a distributed cloud computing platform using mobile nodes connected via cellular network.  Such a “Mobile Cloud” capability is motivated by situations in which the cellular access network has limited backhaul bandwidth to the Internet as may be the case in developing regions or disaster recovery scenarios. In view of the growing importance of the OpenStack and Hadoop/MapReduce framework, we first evaluate the performance of Hadoop in the mobile cloud environment and then consider modifications necessary to improve performance. The study was conducted using an experimental methodology based on the GENI open WiMAX base station at WINLAB, which was used to set up a cluster of 4G/cellular mobile clients running Hadoop. The results show that as expected, performance of Hadoop cloud applications is severely degraded due to mobile device channel quality variations in the baseline case, but that significant improvements (~5x in run-time) can be realized with relatively modest cross-layer (i.e. base-station and signal-to-noise ratio) aware strategies. The results also show that, there are certain types of applications that are not suitable for Distributed Mobile Computing, e.g. applications that generate large outputs, while applications with small sized output benefit greatly from Mobile Cloud.
Using autonomous virtual agents to study the perception of intention
Creators: name: Pantelis, Peter C.
Publisher: name: No Publisher Supplied
Year: 2013

description: Mental states (e.g., goals, beliefs, and intentions) may be attributed to agents on the basis of motion cues, and previous studies have successfully related low-level perceptual qualities of a stimulus agent’s trajectory (i.e. speed, acceleration, or other manner of motion) to resulting subjective percepts. I argue for a powerful and novel experimental paradigm, in which I utilize a two-dimensional virtual environment populated by autonomous agents whose simulated vision, memory, and decision making capabilities can be manipulated. These agents—nicknamed “IMPs” (Independent Mobile Personalities)—navigate the environment, collecting “food” and interacting with one another. Their behavior is modulated by a small number of distinct goal states: attacking, exploring, fleeing, and gathering food. In a first study, subjects attempt to infer and report the IMPs’ continually changing goal states on the basis of their motions and interactions. Although these programmed ground truth goal states are not directly observable, subjects estimate them accurately and systematically. I present a Bayesian model of the inference of goal states which accurately predicts subjects’ responses, including their pattern of errors. In a second study, I use simulated evolution to create a pool of evolved IMPs which exhibit adaptive behavior. I operationally define IMPs sampled from this simulated evolution as being more rational compared to non-evolved “control” IMPs, and find that subjects construe evolved IMPs as being both more intelligent and more human-like than non-evolved IMPs. In a final critical experiment, I demonstrate that subjects are better at discriminating the goal states of evolved IMPs than those of non-evolved IMPs. The two studies I present in this thesis provide empirical support for an account of adult “theory of mind” which asserts that 1) the inference of latent mental states can be understood as the inversion of a model of the generative processes producing the observable behavior of the agent, 2) this generative model reflects expectations of agent rationality, and 3) evolutionary fitness is a reasonable operational model of apparent agent rationality, to which subjects are sensitive. These experiments also demonstrate that using autonomous agents as stimuli opens up many basic research questions in the study of the interpretation of intentionality.
Additional file 1: of Radial extracorporeal shock wave therapy is efficient and safe in the treatment of fracture nonunions of superficial bones: a retrospective case series
Creators: name: Kertzman, Paulo
name: Csรกszรกr, Nikolaus
name: Furia, John
name: Schmitz, Christoph
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology

description: Details of all studies on focused extracorporeal shock wave therapy (fESWT) for fracture nonunions listed in PubMed (as of March 01, 2017). (DOCX 76ย�kb)
Enabling positron emission tomography tracer synthesis on a chip: electrochemical micro-flow cell for concentration and drying of [F-18]fluoride
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Introduction: Positron emission tomography (PET) is a powerful tool for in vivo imaging of living subjects with extremely high sensitivity and molecular specificity. It provides critical information in the study of the molecular mechanisms of cancer, development of new anti-cancer drugs, diagnosis of cancer in the clinic, and monitoring patient response to treatment. Difficulty and cost of producing tracers labeled with short-lived positron-emitting isotopes just prior to imaging severely limits the use of PET. Emerging integrated microfluidic devices (PDMS with pneumatic microvalves, and electrowetting-based EWOD chips) can perform multi-step chemical reactions in disposable chips and promise simplified, low-cost tracer production, enabling greater access to PET and fueling the development of a diversity of probes targeting new biochemical pathways. A key missing element of this technology, though, is a practical means to load [F-18]fluoride from the large target volume of the cyclotron (2 mL) to the miniscule reaction volume of the chips (1 uL). Aims: Electrochemical trapping of [F-18]fluoride ion from [O-18]H2O after production in a cyclotron has been demonstrated as a rapid and effective means to remove water, a crucial first step for most radiosyntheses involving F-18. In all published studies, the output volume is large (100s of uL), and therefore suitable only for conventional-scale approaches or simple flow-through capillary microreactors. However, analysis of the engineering design of previous systems suggests that significant improvements can be made to achieve comparable efficiency but with far smaller volumes (a few uL), which would be perfectly suited to resolve the above missing link. Our aim is to build and study an electrochemical trapping system to test this hypothesis, optimize the system for low-volume output, and validate its performance. Methods: We will construct a 2nd-generation flow cell and measurement system, and use it to study and optimize the controllable variables in the system. Quality of F-18 will be established by wellknown radiofluorination reactions. Based on optimized conditions, we will then design a compact integrated microfluidic electrochemical trapping device with minimal dead-volumes, and integrate it with existing PDMS or EWOD synthesis chips from our lab and demonstrate synthesis of a large dose of tracer (sufficient for human imaging) for the first time in one of these chips.
Tetramorium weitzeckeri
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium weitzeckeri

description: The weitzeckeri -group
Antennae with 11 segments, the sting appendage spatulate. Mandibular sculpture varying from strongly longitudinally striate to absolutely smooth. Nodes of petiole and postpetiole unsculptured, at least the petiole tending to be anteroposteriorly compressed, strongly squamiform in some species. More rarely the postpetiole also squamiform.
The weitzeckeri-group is the commonest group of species with 11 - merous antennae in the Ethiopian region, where about 13 species are present. Four endemic species of this group are known from Madagascar and an African species, humbloti, is known from the Comoro Islands but has not yet been recorded from Madagascar proper. These five species fall into two close species-pairs and a solitary, less easily accounted for species. The first pair, bessoni and humbloti, have the alitrunk rounded transversely above, with very reduced pilosity and sculpture. The second pair, dysalum and marginatum, have the alitrunk flat transversely above and the sides strongly marginate. The final species, steinheili, is a much larger and more robust form which in many respects approaches the tortuosum-group.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 139-140
Characidae Latreille 1825
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae

description: Family Characidae Latreille 1825 (Fig. 3B). Characins, Tetras; Sardinas, Sardinitas de Río, Sabaletes
Description: Body fusiform to slightly elongate, compressed to strongly compressed; usually less than 15 cm in length; upper jaw usually not projecting well beyond the tip of the lower jaw, upper jaw usually with 1–2 rows of multicuspid teeth; fins spine-less; adipose fin present; caudal fin forked; generally silvery in color (Angulo et al. 2021). Distribution: Freshwater; southwestern Texas, USA, Mexico and Central and South America (Nelson et al. 2016). Five genera and eleven species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 22, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Regulation of the PAH1-encoded phosphatidate phosphatase and its role in lipid metabolism in yeast
Creators: name: Pascual, Florencia
Publisher: name: No Publisher Supplied
Year: 2013

description: The yeast PAH1-encoded phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol (TAG).  PAP plays a crucial role in lipid homeostasis by controlling the relative proportions of its substrate phosphatidate (PA) and its product diacylglycerol (DAG). The cellular amounts of these lipid intermediates influence the synthesis of TAG and the pathways by which membrane phospholipids are synthesized.  The importance of this enzyme is exemplified by the severe phenotypes of the pah1 mutant that include deregulation of phospholipid synthesis, an aberrant expansion of the nuclear/ER membrane, a decrease in lipid droplet formation, a massive reduction in TAG content, defects in vacuole homeostasis and fusion, and increased sensitivity to lipotoxicity.  On the other hand, the attenuation of PAH1-encoded PAP function is also essential to normal cell physiology.  Indeed, the overexpression of an unregulated form of PA phosphatase inhibits cell growth, and this is attributed to the depletion of PA needed for phospholipid synthesis via CDP-DAG and the accumulation of DAG to a toxic level.  TAG accumulates in the stationary phase of growth, and the lipid analysis of the pah1 mutant established the essential role of Pah1p PAP in this process.  While Pah1p PAP activity was elevated in stationary phase cells, the expression of PAH1 mRNA and Pah1p was maximal in the exponential phase, but declined as cells entered the stationary phase.  The levels of Pah1p were stabilized in stationary phase cells treated with the proteasome inhibitor MG132 as well as in several mutants that exhibit a decrease in proteasome function.  Catalytic site mutant forms of Pah1p exhibited increased stability in stationary phase, indicating that the balance of PA and DAG acts as a signal for the degradation of the enzyme.  Additionally, Pah1p levels were also stabilized in cells overexpressing DGK1, pointing to PA as a possible regulator of Pah1p stability.  This work reveals a novel mechanism for the control of Pah1p PAP function in yeast.
Time resolved electrophoretic and electroosmotic velocities
Creators: name: Patel, Ravi Ghanshyam
Publisher: name: No Publisher Supplied
Year: 2013

description: Electroosmotic pumps show promise in many fields. For example, several lab-on-chip devices have been proposed the make use of these devices (1). This thesis will focus on finding the fluid velocity distribution inside an electroosmotic pump. First, the fluid velocity was calculated for an electroosmotic pump using a bipolar pulse train voltage. Next, the particle velocity for particles suspended in the fluid was found. A glass electroosmotic pump was constructed using a glass capillary tube. Using a 1mM Borate buffer solution and 0.5µm Fluosphere particles, time resolved micro particle image velocimetry (TRµPIV) was performed on the pump to obtain the particle velocity distribution inside the pump. The experiment fluid velocity was calculated from this particle velocity. The experimental particle and fluid velocities show excellent agreement with the theoretical calculations.
Chlamydia and cancer? Mechanism of centrosome dysregulation in an infected cell
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chlamydia trachomatis has been associated with cervical cancer in sero-epidemiologic studies. A potential mechanism by which Chlamydia may contribute to oncogenesis is through defects in the centrosome that have been observed in Chlamydia-infected cells. In work to date, we have found that a chlamydial protease cleaves a regulator of centrosomal dupiciation, producing a stabilized form of the protein that is sufficient to produce multiple centrosomes. In this application, we describe a new finding that three additional centrosomal proteins are altered during a Chlamydia infection. Each of these proteins is involved in regulating a different aspect of centrosome organization and function, and thus it is possible that Chlamydia causes centrosome dysregulation through multiple different effects. We propose to identify the protease or proteases that cleave these three centrosomal proteins by establishing an in vitro cleavage assay for each protein. We will then test specific chlamydial proteases starting with proteases that are known to cleave host substrates. The methods will include in vitro experiments to block cleavage with protease inhibitors or by immunodepletion of specific proteases. We will also attempt to reconstitute cleavage with recombinant forms of chlamydial proteases. We will perform in vivo studies to validate that a specific protease can cleave the target protein in the absence of a chlamydial infection. The identification of the proteases that cleave centrosomal proteins will allow us to understand how this intracellular bacterium targets the centrosome. These studies will set the stage for us to examine the consequences of Chlamydia-induced effects on centrosome function, with particular reference to chromosomal instability and the potential for cancer development.
Tetramorium bessoni
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium bessoni

description: Tetramorium bessoni Forel
(Fig. 9)
Tetramorium {Xiphomyrmex) bessonii Forel, 1891 a: 156, pl. 4, figs 13,13 a. Syntype workers, Madagascar: Pays des Betsileo, Fianarantsoa (Besson) (MHN, Geneva) [examined]. Tetramorium (Xiphomyrmex) bessonii var. orientale Forel, 1895 a: 247. Holotype worker, Madagascar: Imerina oriental (Sikora) (MHN, Geneva) [examined]. Syn. n.
Worker. TL 4.0 - 4.2, HL 0.88 - 0.90, HW 0.82 - 0.86, CI 90 - 95, SL 0.60 - 0.70, SI 74 - 80, PW 0.62 - 0.66, AL 1.08 - 1.14 (6 measured).
Mandibles striate, median clypeal and cephalic carinae well defined and distinct. Frontal carinae strongly developed but antennal scrobes weak. Propodeum armed with a pair of stout spines, the metapleural lobes low and rounded. In profile the petiole strongly antero-posteriorly compressed, thicksquamiform, the node much higher than long. Postpetiole also somewhat compressed. In dorsal view both petiole and postpetiole much broader than long. Clypeus with median and one or two pairs of lateral carinae, the spaces between them feebly or not sculptured. Dorsum of head with median carina and a few widely spaced, weak longitudinal rugulae on each side between median and frontal carinae. These rugulae variable, may be almost completely effaced to quite distinct. Ground-sculpture between the rugulae a very weak, superficial punctulation, again nearly effaced in some individuals. Dorsal alitrunk, pedicel and gaster unsculptured or at most with a few very faint rugulae in the vicinity of the metanotal groove. Erect to suberect hairs present on all dorsal surfaces of head and body but very sparse or (rarely) absent from the first gastral tergite. Colour a uniform medium-brown.
This species is closest related to humbloti, an African species which is known to occur on the Comoro Islands but has not yet been reported from Madagascar itself. The two are separated by sculpture, which on the head of humbloti is coarse and by the presence in bessoni of a number of erect or suberect hairs on the dorsal alitrunk, which is usually completely hairless in humbloti.
Material examined
Madagascar: La Mandraka (W. L. & D. E. Brown); Prov. Diego S., above Sakaramy (W. L. & D. E. Brown).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 141
A change is going to come: EMT vs MET
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Squamous cell carcinoma (SCC) represents approximately 96% of all oral cancers. The 5 year survival rate for this disease has not improved in over 60 years and remains at less than 50%. Epithelial to Mesenchymal Transition (EMT) is the process by which oral cancer becomes poorly differentiated and invasive. TGFß1 is activated by avß6 and promotes EMT. avß6 binds to its ligand (LAP, fibronectin or tenascin-C) in an RGD dependent fashion. avß6 binding to its ligand initiates a multitude of signals like cell adhesion, migration, and angiogenesis; all of which are associated with EMT (Avraamides et al., 2008). The localization of ?vß6 to the tumor-stromal interface can provide a mechanism by which oral cancer cells can sequester and activate TGFß1 thereby localizing it and restricting the effects of its action. The aim of this project is to determine whether Mesenchymal to Epithelial Transition can be promoted by the ß6 integrin? To achieve this end, we will express ß6 constructs expressing different abilities to activate TGFß1. Preliminary data indicates the C-terminal 18 AA of ß6 regulate the activation of TGFß1and Notch. Snail which is highly expressed during EMT is activated synergistically by Notch and TGFß1. Therefore interfering with ß6 activation of TGFß1 would suppress Snail and EMT; further emphasizing the importance of the ß6/TGFß1 interactions. Our goal is to promote change and to induce the reverse pathway of: Mesenchymal to Epithelial Transition (MET). Experimental outcome will be evaluated histologically and by Western blotting for specific EMT-associated molecules, including Notch and MAPK. Functional assays using the mink lung epithelial cell line (TMLC) reporter system will be used to evaluate the ability of the SCC transfectants to activate TGFß1 (Abe et al., 1994). We also will examine the potential role of Notch and TGFß1 in sustaining Snail activation. . Lastly, angiogenic potential of the SCC cells will be examined in vitro. In vivo, avß6 expressing oral cancer cells form blood vessels in a process known as vascular mimicry. We will investigate whether vascular mimicry in oral SCC is a function of TGFß1 activation. Rather than using antibodies, we will modify the inherent ß6 mechanism of TGFß1 activation. We suggest that the activation of TGFß1 by ß6 integrin is central to maintaining the mesenchymal phenotype and the inclusion of additional molecules such as Notch and MAPK as important contributors to EMT have the potential to link this process with a host of other pathways yet to be a
Narratives of African improvement
Creators: name: Paustian, Megan Cole
Publisher: name: No Publisher Supplied
Year: 2013

description: “Narratives of African Improvement: Missions, Humanitarianism, and the Novel” explores the relationship between narrative and international development, analyzing literature’s contribution to debates about religious and humanitarian missions. International plans for improving Africa consistently operate on the basis of what I call the Mission narrative, the optimistic story of benevolent Westerners offering salvation to supposedly benighted Africans. Drawing on sociopolitical critiques, this dissertation begins from the premise that many of the dangers and disasters that characterize humanitarian action are related to the narrative through which it frames its task. If narrative is the problem, I ask what role the novel—that extended, complicated, multifaceted form of narrative—might take in imagining and articulating better narratives of African improvement. To that end, I define a micro-genre of critical literature that I term the critical mission novel, which works to dismantle the grand Mission narrative while also taking seriously the urgent questions it raises about global inequity and the ethics of transnational concern. Each chapter focuses on a problematic node within the Mission narrative—the manifestation of faith, emancipation through foreign sources, the concept of universal humanity, and the politics of giving—exploring how a set of novels critiques and rethinks it. Each of these nodes is deeply fraught, on the one hand extremely dangerous and the other intensely compelling, thus opening up an ambivalent field of rejection and tentative embrace. Building this kind of problem-based literary history, results in a thoroughly transnational project which brings together African, British, and U.S. writers typically read within separate traditions, including Joseph Conrad, Chinua Achebe, Ngũgĩ wa Thiong’o, Bessie Head, Tstitsi Dangarembga, Barbara Kingsolver, Philip Caputo, Nuruddin Farah, and Zakes Mda. These novelists demystify and reinvent the vocabulary of benevolence, situate “ethical” interventions within a political network of social relations, and negotiate the tension between utopian desire and real world necessity, cultivating points of resonance with non-ideal allies in non-ideal times. Humanitarian thought and action have been hindered by various fictions—the fictions of African darkness, Western enlightenment, inevitable progress, and spectacular salvation—all posing as truth. Ironically, fiction itself may hold the most sophisticated alternatives.
Astyanax aeneus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax aeneus

description: Astyanax aeneus (Günther 1860). Banded Tetra; Sardina, Sardina de Río, Sardinilla, Sabalete, Sábalo, Sardina Común, Plateada, Machaca, Coliroja, Picaculo, Golosa, Tetra, Mojarra
Vouchers: Not available. Distribution: Central America; from central Mexico to southern Honduras-northern Nicaragua, Pacific drainages; (Nicaragua) Ch (Pacific); 279–319 masl; Pri, Pot. Occurrence and conservation status: Nat; LC (2019), population trend stable. Literature: Carr & Giovannoli (1994: 97, as Astyanax fasciatus aeneus —synonym; brief description, including information on distribution and ecology) and Schmitter-Soto (2017: 22; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 22, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Additional file 1: of Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial
Creators: name: Cheng, William
name: Wold, Karl
name: Benzoni, Nicole
name: Thakwalakwa, Chrissie
name: Maleta, Kenneth
name: Manary, Mark
name: Indi Trehan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 120 kb)
Additional file 1: of Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial
Creators: name: Cheng, William
name: Wold, Karl
name: Benzoni, Nicole
name: Thakwalakwa, Chrissie
name: Maleta, Kenneth
name: Manary, Mark
name: Indi Trehan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 120 kb)
Consonant-tone interaction in Thai
Creators: name: Perkins, Jeremy M.
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation establishes that phonological consonant-tone interaction occurs in a non-local configuration in Thai, in contrast to current theories where this interaction is only thought to occur locally. A phonological account posits that in bimoraic unchecked syllables, tones associated with the second mora, and not the first mora, interact with onset consonants in Thai. This is implemented via an Optimality-theoretic markedness constraint, *[+CG]-[H]μ2. Evidence for this position comes from a quantitative lexical gap study and a pair of judgment experiments, which show that both rising tone and high tone are ungrammatical in unchecked syllables with laryngealized obstruent onsets. In Thai, these tones share a common high-tone target at the end of the syllable. These facts suggest the presence of a phonological constraint violated by onset-tone sequences, where the tone on the second mora is referenced, despite the fact that it is the more distant of the two. This constraint is grounded since it is phonologically less marked for tones to be realized late in syllables – the second mora is treated as the “head” mora of the syllable in Thai.   This phonological analysis is supported via evidence from an acoustic study of voiced and unaspirated obstruent onsets in Thai. It is discovered that these obstruents are articulated with laryngeal constriction, and that they form a natural class under the feature [+constricted glottis] A second important contribution of the acoustic study was that [ʔ] onsets are phonetically distinct (they raise F0 and spectral tilt), even though they are part of the same phonological [+constricted glottis] class.   Two judgment experiments confirm the psychological reality of the constraint *[+CG]-[H]μ2 among native Thai words. However, three of four onset-tone sequences that violate this constraint are considered grammatical under interpretation as English loans. This result is consistent with findings in other languages, where loan strata are more permissive than native strata. In addition, participants exhibited preferences for [+constricted glottis] onsets and low tone that cannot be explained via language experience. Therefore, it is argued that the relative ranking of markedness constraints can distinguish between grammatical forms, a finding that replicates previous experiments in English and Hebrew.
Additional file 1:Table S1. of High-throughput gadobutrol-enhanced CMR: a time and dose optimization study
Creators: name: D’Angelo, Tommaso
name: Chrysanthos Grigoratos
name: Mazziotti, Silvio
name: Bratis, Konstantinos
name: Faraz Pathan
name: Blandino, Alfredo
name: Elen, Elen
name: Puntmann, Valentina
name: Nagel, Eike
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Pharmacology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Late enhancement qualitative results at the different time delays for different doses of gadobutrol. Table S2. Late enhancement quantitative results (percentage of LGE myocardial mass) obtained at 10 min with 0.1 mmol/kg protocol and at 15 min with 0.2 mmol/kg protocol. (DOCX 58 kb)
Tetramorium dysalum Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium dysalum

description: Tetramorium dysalum sp. n.
(Fig. 24)
Holotype worker. TL 3.1, HL 0 - 72, HW 0.71, CI 99, SL 0.50, SI 70, PW 0.52, AL 0.84.
Mandibles smooth and shining, unsculptured except for minute pits. Anterior clypeal margin with an impression or notch. Frontal carinae strong, surmounted by a narrow raised rim or flange. Alitrunk sharply marginate anteriorly and laterally, the margination of the sides interrupted at the promesonotal junction and more strongly impressed at the metanotal area, between mesonotum and propodeum. Pronotal dorsum transversely flat, the propodeal dorsum transversely feebly concave. Propodeum with a pair of long, acute spines which are slightly downcurved along their length. Metapleural lobes triangular. Node of petiole in profile high and quite narrow, the anterodorsal angle somewhat higher than the posterodorsal so that the slightly convex dorsal surface slopes downwards posteriorly. Dorsum of head regularly longitudinally rugulose, the interspaces with very feeble superficial ground-sculpture. Dorsal alitrunk strongly longitudinally rugose. Petiole and gaster unsculptured but dorsum of postpetiole with very faint traces of superficial sculpture. All dorsal surfaces of head and body with numerous elongate, fine hairs. Colour uniform brown.
Paratype workers. TL 2.7 - 3.1, HL 0.64 - 0.72, HW 0.60 - 0.71, CI 95 - 100, SL 0.43 - 0.50, SI 68 - 73, PW 0.46 - 0.52, AL 0.74 - 0.84 (15 measured).
As holotype but some specimens slightly darker in shade than the holotype, often the gaster lighter in shade than the alitrunk. The entire type-series apparently represents a single nest-sample, so the normal size variation in this species is fairly large. The degree of curvature of the propodeal spines varies, most specimens being as holotype but a few have them slightly more or slightly less downcurved.
Holotype worker, Madagascar: Perinet & vic, rain forest, 17. iii. 1969 (W. L. Brown) (MCZ, Cambridge). Paratypes. 39 workers and 1 dealate queen with same data as holotype but on some pins the lower label having ' rot. wood' or ' for. litter' (MCZ, Cambridge; BMNH).
NON-PARATYPIC MATERIAL.
Two series collected more recently by W. L. Brown in Madagascar: vic. Andasibe (= Perinet), 2 - 6. ii. 77, and Mangabe I.: Antongil Bay, 19. ii. 77, agree well with the above description but in the Andasibe series body hairs are darker in colour than in the type-series.
This species appears to be close to marginatum, but in that species the dorsal alitrunk is unsculptured.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 141-142
Synthesis and biology of syrbactin natural proteasome inhibitors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project will prepare libraries of macrolactams based on the natural products syringolin A and glidobactin A (the syrbactins). The methods directly supported by the CRCC grant at UCR will include organic synthesis and combinatorial synthesis. Work that will be performed by our University of Hawaii collaborator outside of this grant will include examining inhibition of the human proteasome by syrbactin analogs using in vitro assays and studying the effects of proteasome inhibitory syrbactin analogs in cancer cells. The objective of this work is to discover novel, potent, and selective macrolactam inhibitors of the mammalian proteasome with anti-cancer activity, and to develop structure-reactivity relationships for the reaction of the macrolactams with the proteasome.
Architectural support for virtual memory in GPUs
Creators: name: Pichai, Bharath
Publisher: name: No Publisher Supplied
Year: 2013

description: The proliferation of heterogeneous compute platforms, of which CPU/GPU is a prevalent example, necessitates a manageable programming model to ensure widespread adoption. A key component of this is a shared unified address space between the heterogeneous units to obtain the programmability benefits of virtual memory. Indeed, processor vendors have already begun embracing heterogeneous systems with unified address spaces (e.g., Intel's Haswell, AMD's Berlin processor, and ARM's Mali and Cortex cores).  We are the first to explore GPU Translation Lookaside Buffers (TLBs) and page table walkers for address translation in the context of  shared virtual memory for heterogeneous systems. To exploit the programmability benefits of shared virtual memory, it is natural to  consider mirroring CPUs and placing TLBs prior (or parallel) to cache accesses, making caches physically addressed. We show the performance challenges of such an approach and propose modest hardware augmentations to recover much of this lost performance.  We then consider the impact of this approach on the design of general purpose GPU performance improvement schemes. We look at: (1) warp scheduling to increase cache hit rates; and (2) dynamic warp formation to mitigate control flow divergence overheads. We show that introducing cache-parallel address translation does pose challenges, but that modest optimizations can buy back much of this lost performance.   In the CPU world, the programmability benefits of address translation and physically addressed caches have outweighed their performance overheads. This paper is the first to explore similar address translation mechanisms on GPUs. We find that while cache-parallel address translation does introduce non-trivial performance overheads, modestly TLB-aware designs can move performance losses into a range deemed acceptable in the CPU world. We presume this stake-in-the-ground design leaves room for improvement but hope the larger result, that a little TLB-awareness goes a long way in GPUs, sets the stage for future work in this fruitful area.