cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
Creators: name: Fletcher, Katherine Anne
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: autophagy
non-canonical autophagy
LC3 associated phagocytosis
macropinocytosis

description: Autophagy is a well-studied catabolic process through which cytoplasmic components are targeted for lysosomal degradation by autophagosomes. A key step in this process is the recruitment, processing and lipidation of LC3 to autophagosomes. Recently it has become increasingly apparent that, through the unconventional use of some autophagy related proteins, LC3 can also become lipidated to distinct non-autophagosomal membranes of the endolysosomal system. This process is termed non-canonical autophagy and occurs independently of conventional autophagy initiation signals. Non-canonical autophagy usually occurs after macro endocytic engulfment events such as macropinocytosis, entosis and LC3 associated phagocytosis (LAP). Certain ionophores and lysosomotropic drugs, such as monensin, can also activate this process and promote LC3 lipidation to lysosomes. This project focuses on Atg16L1, an essential autophagy protein that directs the membrane site where LC3 is lipidated. Atg16L1 is relatively well characterised in autophagy but little is known about the mechanisms underlying its role in non-canonical autophagy. This project used a structure/function approach to assess the importance of different domains of Atg16L1 in the context of autophagy versus non-canonical autophagy. I have demonstrated for the first time, that the Atg16L1 C-terminal WD40 domain (CTD) is dispensable for its role in autophagy but essential for LC3 lipidation during non-canonical autophagy. Furthermore, single point mutants were uncovered in the CTD of Atg16L1 that likewise are dispensable for autophagy but fundamental to LC3 lipidation in non-canonical autophagy. These data provide a novel strategy for dissecting canonical and non-canonical autophagy pathways at a molecular level. This project used an existing mouse model with an Atg16L1 truncation (lacking the CTD and nearby residues) and implicated the lack of non canonical autophagy to a defect in MHCII antigen presentation. Furthermore this project has generated new refined Atg16L1 mutant models ablating non-canonical autophagy without affecting canonical autopahgy. In parallel, proteomic analysis was done to provide mechanistic insights into Atg16L1 binding partners in the context of non-canonical autophagy.
description: BBSRC
title: Appel ATED 2017
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Appel diffusé dans le cadre du programme ATED, diffusé par le LabexMed.
Computational Fluid Dynamics Investigation of Oscillatory Behaviour in Annular Combustors
Creators: name: Valreau, Audrey Sophie Lisa
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Combustion
Combustion Instability
CFD
Annular Combustor
Oscillatory Behaviour

description: The drive towards environmentally-friendly gas turbine engines imposes strict design constraints on combustion chambers to minimise harmful pollutant emission. Measures employed to counter this issue may result in oscillatory behaviour, which can cause substantial damage to the engine. Recent work has been undertaken on predicting this behaviour in annular combustors. The complexity of the annular design can give rise to an additional set of intricate oscillations due to the presence of interactions between neighbouring flames. The project is concerned with capturing trends in oscillatory behaviour in the laboratory-scale annular combustion chamber designed by Worth and Dawson. Combustion-driven oscillations are studied by a variety of methods including experimental, analytical and Computational Fluid Dynamics (CFD) approaches. The cost associated with experimental studies and the limitations of most analytical models in representing complex flow phenomena both put CFD forward as a preferred tool for the present work. The aim was to create a modelling approach that maximises efficiency in both computational time and cost, to be fit for use in an industrial context. Three objectives are defined: to develop an efficient numerical methodology to bridge the gap between analytical and high-order CFD investigations; to identify ways in which to reduce computational demands in the CAD and meshing methods; and to compare the results obtained to available reference data. A set of new inlet boundary conditions, a modular CAD geometry and a coarse meshing approach are developed to answer the computational efficiency constraint. The method also considers the use of lower-order turbulence models to reduce computational demands. Cyclic boundary conditions are applied to a single sector of the annular geometry to reduce the size of the domain. The numerical methodology developed is compared to reference data in isothermal, reacting and forced-inlet reacting cases. Its adaptability to various operating conditions is explored by observing trends in flow behaviour with varying inlet velocity and temperature, fuel, equivalence ratio, and forcing amplitude. It is shown at each stage that the modelling approach is capable of representing expected trends. This is achieved at a fraction of the cost compared to full burner configuration studies or higher-order CFD simulations. The thesis provides evidence that the computational methodology developed can be used to describe trends in forced oscillatory behaviour efficiently in the Worth and Dawson annular combustor rig, in the context of the reference cases studied. Additional work is necessary to determine the full scope of applicability of the new methodology.
description: EU/EEC Clean Sky DYNAMO, Rolls-Royce Plc.
Dairy farms efficiency analysis before the quota system abolishment
Creators: name: Kovács, Krisztián
name: Kovács, Krisztián
Publisher: name: Unknown
Year: 2014
Subjects: subject: Agribusiness
subject: Agricultural Finance
subject: Farm Management
subject: Production Economics
subject: efficiency
subject: dairy sector
subject: data envelopment analysis (DEA)
subject: stochastic frontier analysis (SFA)

description: The abolishment of the dairy quota system in the EU is expected to increase competition across dairy farms in Europe. Assuming a common price for milk in the EU, only the most efficient farms will survive in the new environment. The main objective of the research is to compare dairy farms in Germany, The Netherlands and Hungary about their technical efficiency. In the first part of the research, the efficiency is measured by partial efficiency indexes using one dimensional efficiency measuring. In the second part, the Stochastic Frontier Analysis (SFA) have to be used to measure efficiency in a multidimensional space, using six inputs and two outputs. It appears from the results that the highest efficiency farms are in the Netherlands, and then Germany and Hungary follow thus, we get that the most efficient farms are in the Netherlands with 84% efficient. The German farms are 76% efficient. The Hungarian farms are 68% efficient. With respect the abolishment of the dairy quota system, our results suggest that the Dutch farms are the most efficient, thus probably they will increase their production after the quota system. But because the size of the country we cannot expect dramatic changes in the European Dairy market. The Germans farms efficiency is lower, but their efficiency is also lower, so we won’t expect high increase about the dairy supply. The Hungarian dairy sector is not so efficient like the Dutch, and the size of the sector has also small among the European countries, thus if they want to survive the quota system demolishing, they have to increase their technical efficiency.
Hadronic effects in leptonic systems: muonium hyperfine structure and anomalous magnetic moment of muon
Creators: name: Eidelman, S. I.
name: Karshenboim, S. G.
name: Shelyuto, V. A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Contributions of hadronic effects to the muonium physics and anomalous magnetic moment of muon are considered. Special attention is paid to higher-order effects and the uncertainty related to the hadronic contribution to the hyperfine structure interval in the ground state of muonium.
description: Presented at PSAS 2002 (St. Petersburg)
The effects of blending on the light curve shape of Cepheids
Creators: name: Antonello, E.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A short analysis is presented of the effects on the cepheid light curve shape, i.e. on the Fourier parameters usually adopted for its description, of the blending of the stellar image with other close stars. The conclusion is that, within reasonable error, the effects are in general small and the Fourier decomposition is confirmed to be a useful tool for pulsation mode discrimination. A large effect has been found on the phase differences in a narrow period range corresponding to the known resonance centers between pulsation modes.
description: 5 pages; Research Note submitted to A&A
Aspects of a Two-Level Atom in Squeezed Displaced Fock States
Creators: name: Obada, A. -S. F.
name: Abdal-Kader, G. M.
name: Abdel-Aty, Mahmoud
Publisher: name: arXiv
Year: 2001
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper presents some results on some aspects of the two-level atom interacting with a single-mode with the privileged field mode being in the squeezed displaced Fock state (SDFS). The exact results are employed to perform a careful investigation of the temporal evolution of the atomic inversion, entropy and phase distribution. It is shown that the interference between component states leads to non-classical oscillations in the photon number distribution. At mid revival time the field is almost in the pure state. We have briefly discussed the evolution of the Q function of the cavity field. The connection between the field entropy and the collapses and revivals of the atomic inversion has been established. We find that the phase probability distribution of the field reflect the collapses and revivals of the level occupation probabilities in most situations. The interaction brings about the symmetrical splitting of the phase probability distribution. The general conclusions reached are illustrated by numerical results.
description: 20 pages, 5 figures, Accepted in Physica Scripta
Generalized symmetries, conservation laws and Hamiltonian structures of an isothermal no-slip drift flux model
Creators: name: Opanasenko, Stanislav
name: Bihlo, Alexander
name: Popovych, Roman O.
name: Sergyeyev, Artur
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 37K05 (Primary) 76M60, 35B06 (Secondary)

description: We study the hydrodynamic-type system of differential equations modeling isothermal no-slip drift flux. Using the facts that the system is partially coupled and its subsystem reduces to the (1+1)-dimensional Klein--Gordon equation, we exhaustively describe generalized symmetries, cosymmetries and local conservation laws of this system. A generating set of local conservation laws under the action of generalized symmetries is proved to consist of two zeroth-order conservation laws. The subspace of translation-invariant conservation laws is singled out from the entire space of local conservation laws. We also find broad families of local recursion operators and a nonlocal recursion operator, and construct an infinite family of Hamiltonian structures involving an arbitrary function of a single argument. For each of the constructed Hamiltonian operators, we obtain the associated algebra of Hamiltonian symmetries.
description: 36 pages, extended version, the proof on cosymmetries in presented with more details
Tunneling measurement of quantum spin oscillations
Creators: name: Bulaevskii, L. N.
name: Hruška, M.
name: Ortiz, G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider the problem of tunneling between two leads via a localized spin 1/2 or any other microscopic system which can be modeled by a two-level Hamiltonian. We assume that a constant magnetic field ${\bf B}_0$ acts on the spin, that electrons in the leads are in the thermal equilibrium and that the tunneling electrons are coupled to the spin through exchange and spin-orbit interactions. Using the non-equilibrium Keldysh formalism we find the dependence of the spin-spin and current-current correlation functions on the applied voltage between leads $V$, temperature $T$, ${\bf B}_0$, and on the degree and orientation ${\bf m}_α$ of spin polarization of the electrons in the right ($α=$R) and left ($α=$L) leads. We compare our results of a full quantum-mechanical treatment of the tunneling-via-spin model with those previously obtained in the quasi-classical approach, and discuss the experimental results observed using STM dynamic probes of the localized spin.
description: 15 pages, 12 figures
Additional file 1: of Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy
Creators: name: Ebner, Florian
name: Harmon, Matt
name: Aneman, Anders
name: Cronberg, Tobias
name: Friberg, Hans
name: Hassager, Christian
name: Juffermans, Nicole
name: KjĂŚrgaard, Jesper
name: Kuiper, Michael
name: Mattsson, Niklas
name: Pelosi, Paolo
name: UllĂŠn, Susann
name: UndĂŠn, Johan
name: Wise, Matt
name: Nielsen, Niklas
Publisher: name: figshare
Year: 2018
Subjects: Neuroscience
Pharmacology
Biological Sciences not elsewhere classified
Science Policy
Computational Biology

description: Tables presenting detailed information on the excluded cohort, exposure group 6-month neurological outcome, and sensitivity analyses. (DOCX 23 kb)
Cosmic Ray Acceleration by Magnetic Traps
Creators: name: Zirakashvili, V. N.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Cosmic ray acceleration in turbulent interstellar medium is considered. Turbulence is treated as ensemble of moving magnetic traps. We derive equations for particle momentum distribution function that describes acceleration of particles in this case. Rate of acceleration calculated is estimated for our Galaxy and compared with ones given by other acceleration mechanisms.
description: 4 pages, LaTeX, published in Proc. 26th ICRC
title: Ermittlung des CO₂-Fußabdrucks einer Freizeitveranstaltung am Beispiel eines Pfadfinderlagers
Creators: name: Papendieck, Irene
Publisher: name: KOBRA Universität Kassel
Year: 2024
Subjects: subject: Ökobilanzierung
subject: Life Cycle Assessment
subject: CO₂-Fußabdruck
subject: Carbon Footprint
subject: Klima
classificationCode: 500
subject: 500
classificationCode: 600
subject: 600
classificationCode: Umweltbilanz
subject: Umweltbilanz
classificationCode: Ökologischer Fußabdruck
subject: Ökologischer Fußabdruck
classificationCode: CO2-Bilanz
subject: CO2-Bilanz
classificationCode: Klima
subject: Klima

description:
In dieser Bachelorarbeit wird ein CO₂-Fußabdruck für das Landeslager des VCP Hessen e.V. 2024 in Anlehnung an DIN EN ISO 14067 ermittelt und auf seine Zusammensetzung hin untersucht. Der ermittelte Wert liegt absolut bei 55.933,00 kg CO₂-Eq., wobei 78,7 % auf die Mobilität, 15,7 % auf die Lebensmittel und 5,6 % auf die Energie zurückzuführen sind. Pro Person und Tag beträgt der CO₂-Fußabdruck des Landeslagers 10,36 kg CO₂-Eq.
Anhand einer Szenarienanalyse werden vom Planungsteam bereits umgesetzte Klimaschutzmaßnahmen auf ihre Wirksamkeit untersucht und weitere Potentiale zur Verringerung des CO₂-Fußabdrucks identifiziert. Die Aufforderung, mit umweltfreundlichen öffentlichen Verkehrsmitteln an- und abzureisen, war demnach besonders wirksam, während die Entscheidung für eine vegetarische Verpflegung und der Kauf von Fahrrädern für den Zeltplatz zwar die CO₂-Fußabdrücke der jeweiligen Prozesse signifikant senken konnten, auf das gesamte Landeslager bezogen jedoch einen deutlich geringeren Effekt hatten. Gleiches gilt für weiterführende Klimaschutzmaßnahmen, die in dieser Untersuchung analysiert werden wie das Umstellen auf eine vegane Verpflegung und der Wechsel zu erneuerbaren Energien.
On the motive of O'Grady's ten-dimensional hyper-Kähler varieties
Creators: name: Floccari, Salvatore
name: Fu, Lie
name: Zhang, Ziyu
Publisher: name: arXiv
Year: 2019
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14D20, 14C15, 14J28, 14F05, 14J32, 53C26

description: We investigate how the motive of hyper-Kähler varieties is controlled by weight-2 (or surface-like) motives via tensor operations. In the first part, we study the Voevodsky motive of singular moduli spaces of semistable sheaves on K3 and abelian surfaces as well as the Chow motive of their crepant resolutions, when they exist. We show that these motives are in the tensor subcategory generated by the motive of the surface, provided that a crepant resolution exists. This extends a recent result of Bülles to the O'Grady-10 situation. In the non-commutative setting, similar results are proved for the Chow motive of moduli spaces of stable objects of the K3 category of a cubic fourfold. As a consequence, we provide abundant examples of hyper-Kähler varieties of O'Grady-10 deformation type satisfying the standard conjectures. In the second part, we study the André motive of projective hyper-Kähler varieties. We attach to any such variety its defect group, an algebraic group which acts on the cohomology and measures the difference between the full motive and its weight-2 part. When the second Betti number is not 3, we show that the defect group is a natural complement of the Mumford--Tate group inside the motivic Galois group, and that it is deformation invariant. We prove the triviality of this group for all known examples of projective hyper-Kähler varieties, so that in each case the full motive is controlled by its weight-2 part. As applications, we show that for any variety motivated by a product of known hyper-Kähler varieties, all Hodge and Tate classes are motivated, the motivated Mumford--Tate conjecture holds, and the André motive is abelian. This last point completes a recent work of Soldatenkov and provides a different proof for some of his results.
description: Published version. Communications in Contemporary Mathematics (open access)
Evidence for Circumburst Extinction of Gamma-Ray Bursts with Dark Optical Afterglows and Evidence for a Molecular Cloud Origin of Gamma-Ray Bursts
Creators: name: Reichart, Daniel E.
name: Price, Paul A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: First, we show that the gamma-ray bursts with dark optical afterglows (DOAs) cannot be explained by a failure to image deeply enough quickly enough, and argue that circumburst extinction is the most likely solution. If so, many DOAs will be ``revived'' with rapid follow up and NIR searches in the HETE-2 and Swift eras. Next, we consider the effects of dust sublimation and fragmentation, and show that DOAs occur in clouds of size R > 10L_{49}^{1/2} pc and mass M > 3x10^5L_{49} M_{sun}, where L is the luminosity of the optical flash. Stability considerations show that such clouds cannot be diffuse, but must be molecular. Consequently, we compute the expected column density distribution of bursts that occur in Galactic-like molecular clouds, and show that the column density measurements from X-ray spectra of afterglows, DOAs and otherwise, satisfy this expectation in the source frame.
description: Invited Review. To appear in Procs. of Gamma-Ray Burst and Afterglow Astronomy 2001: A Workshop Celebrating the First Year of the HETE Mission, 8 pages, 8 figures, LaTeX
Learning to combine primitive skills: A step towards versatile robotic manipulation
Creators: name: Strudel, Robin
name: Pashevich, Alexander
name: Kalevatykh, Igor
name: Laptev, Ivan
name: Sivic, Josef
name: Schmid, Cordelia
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Manipulation tasks such as preparing a meal or assembling furniture remain highly challenging for robotics and vision. Traditional task and motion planning (TAMP) methods can solve complex tasks but require full state observability and are not adapted to dynamic scene changes. Recent learning methods can operate directly on visual inputs but typically require many demonstrations and/or task-specific reward engineering. In this work we aim to overcome previous limitations and propose a reinforcement learning (RL) approach to task planning that learns to combine primitive skills. First, compared to previous learning methods, our approach requires neither intermediate rewards nor complete task demonstrations during training. Second, we demonstrate the versatility of our vision-based task planning in challenging settings with temporary occlusions and dynamic scene changes. Third, we propose an efficient training of basic skills from few synthetic demonstrations by exploring recent CNN architectures and data augmentation. Notably, while all of our policies are learned on visual inputs in simulated environments, we demonstrate the successful transfer and high success rates when applying such policies to manipulation tasks on a real UR5 robotic arm.
description: ICRA 2020. See the project webpage at https://www.di.ens.fr/willow/research/rlbc/
INDIANA’S HUMAN CAPITAL CHANGES: THE ROLE OF MIGRATION
Creators: name: Waldorf, Brigitte
name: Waldorf, Brigitte
Publisher: name: Unknown
Year: 2015
Subjects: subject: Community/Rural/Urban Development
subject: Labor and Human Capital
subject: Migration
subject: Human Capital
subject: Education
subject: Indiana

description: The paper focuses on human capital gains and losses in the state of Indiana that are due to migration. Overall, Indiana’s human capital gain is small and does not compare favorably that of other states. This is primarily due to Indiana not having been able to attract its fair share of the highly educated workers who are disproportionately attracted to coastal states. Without the influx of highly educated immigrants, Indiana would severely lose human capital. Moreover, young highly educated women are identified as playing a major role for Indiana’s human capital accumulation.
Additional file 1 of In-depth transcriptomic analysis of Anopheles gambiae hemocytes uncovers novel genes and the oenocytoid developmental lineage
Creators: name: Saha, Banhisikha
name: McNinch, Colton M
name: Lu, Stephen
name: Ho, Margaret C.W.
name: De Carvalho, Stephanie Serafim
name: Barillas-Mury, Carolina
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
The effects of matter density uncertainties on neutrino oscillations in the Earth
Creators: name: Jacobsson, Bjorn
name: Ohlsson, Tommy
name: Snellman, Hakan
name: Winter, Walter
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compare three different methods to evaluate uncertainties in the Earth's matter density profile, which are relevant to long baseline experiments, such as neutrino factories.
description: 3 pages, 1 figure. Talk given at the NuFact'02 Workshop, London, 1-6 July, 2002
A Risk Processing Analysis of Cattle Procurement by Beef Packers
Creators: name: Miller, Katherine S.
name: Raikes, Ronald
name: Miller, Katherine S.
name: Raikes, Ronald
Publisher: name: Unknown
Year: 1978
Subjects: Food Consumption/Nutrition/Food Safety
Livestock Production/Industries

description: Shifts in the relative importance of alternative coordination arrangements among agricultural producers and processors, and particularly shifts from spot market transactions to forward contracts or vertical integration, may have substantial impacts on the control of agricultural production and thus may be the target of policy actions. One approach to the problem of identifying trends under way in the relative importance of alternative arrangements is to focus on producer and processor choices among marketing and procurement alternatives.In the study reported in this paper, the cattle-procurement decision problem faced by a beef packer was formulated by using a multi-period, parametric quadratic-programming model. Five alternative arrangements for procuring fed cattle were included in the model: spot purchases, purchases through forward contracts with hedging,purchases through forward contracts without hedging,custom feeding, and packer feeding. Gross margins for procurement alternatives were found to be auto-correlated, and this was taken into account in computing variances of the present values of returns. A major conclusion is that , given the dominance of spot transactions in sales of beef carcasses and by-products, a trend away form reliance on spot purchases of fed cattle and toward vertical integration is not likely. especially for risk-averse packers.
Extrinsic regulation of fate choice in mouse haematopoietic stem cells
Creators: name: Oedekoven, Caroline Anna
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Haematopoietic stem cells
Fate choice
Heterogeneity
Stem cell factor
quiescence
Cell cycle regulation

description: Extrinsic regulation of fate choice in mouse haematopoietic stem cells The mechanisms regulating stem cell self-renewal, proliferation, and differentiation are still not fully understood. Improving our knowledge of these processes will not only provide greater insight into stem cell biology but will also have major implications in the understanding of cancer development, since numerous cancers can trace their origins back to single stem cells. It has previously been shown that variations in culture conditions can alter fate choice in haematopoietic stem cells (HSCs). For decades cytokines have been used to maintain and expand mouse and human HSCs in vitro, with a number of studies demonstrating that cytokines directly influence HSCs fate choice. In this thesis, I explored the extrinsic regulation of mouse HSCs fate choice using three different approaches: 1) Modulation of cytokine concentration 2) Establishment of minimal conditions to retain HSCs function in vitro 3) Development of 3D matrices to provide physical support beyond liquid culture The first results chapter (3.1) identifies that the amount of Stem Cell Factor (SCF) signalling does not alter the number of functional HSCs retained, but may alter the degree of clonal expansion post transplantation. Chapter 3.2 demonstrates that minimal cell culture conditions depending solely on gp130 signalling can maintain HSCs as single cells for an extended period of time. These cells retain full functional repopulation potential but present with a myeloid differentiation bias. Finally, Chapter 3.3 represents a first proof-of-principle series of experiments showing that HSCs are better supported on soft substrates, implicating physical forces in influencing HSCs maintenance ex vivo. In conclusion, these findings further confirm that SCF is a key regulator of HSCs fate, but is not essential for the retention of HSCs function. The newly established minimal cell culture medium allows the specific investigation of various molecules affecting HSCs fate choice at the single cell level. Furthermore, it offers a new platform for studying exit from quiescence in a controlled manner over several days. This latter aspect could have major implications for the delivery of gene therapy and for HSCs expansion efforts in the future.
description: Wellcome Trust
Small molecule modification of short oligonucleotides to improve gene silencing therapy
Creators: name: ARELLANO, CARLOS LUIS
Publisher: name: Monash University
Year: 2022
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine
subject: Biotechnology
subject: 100709 Nanomedicine
subject: FOS: Nanotechnology

description: Small interfering RNA (siRNA) is becoming a prevalent oligonucleotide-based therapy because of its ability to silence genes that contribute to debilitating diseases. One known method of improving the delivery of oligonucleotides is through the direct conjugation of a small, targeting molecule. This thesis develops methods to attach three previously unexplored classes of molecules (an antiestrogen, a ceramide, and a bioreducible fluorophore) that overcome several barriers to siRNA delivery. Overall, these materials represent an example of the possibilities for the direct chemical conjugation of commercially-available oligonucleotides and provide a platform for the easy introduction of other modifications of interest.
MOESM5 of Recommended motor assessments based on psychometric properties in individuals with dementia: a systematic review
Creators: name: Trautwein, Sandra
name: Maurus, Philipp
name: Barisch-Fritz, Bettina
name: Hadzic, Anela
name: Woll, Alexander
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5. Study characteristics first search.
Additional file 3: of Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study
Creators: name: Cantier, Marie
name: Morisot, Adeline
name: Guérot, Emmanuel
name: Megarbane, Bruno
name: Razazi, Keyvan
name: Contou, Damien
name: Mariotte, Eric
name: Canet, Emmanuel
name: De Montmollin, Etienne
name: Dubée, Vincent
name: Boulet, Eric
name: Gaudry, Stéphane
name: Voiriot, Guillaume
name: Mayaux, Julien
name: Pène, Frédéric
name: Neuville, Mathilde
name: Mourvillier, Bruno
name: Ruckly, Stéphane
name: Bouadma, Lila
name: Wolff, Michel
name: Timsit, Jean-François
name: Sonneville, Romain
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S2. Organ support, specific anti-tuberculosis therapy, and adjunctive steroids. (DOCX 16 kb)
MOESM6 of Recommended motor assessments based on psychometric properties in individuals with dementia: a systematic review
Creators: name: Trautwein, Sandra
name: Maurus, Philipp
name: Barisch-Fritz, Bettina
name: Hadzic, Anela
name: Woll, Alexander
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Additional file 6. Study characteristics main search.
Barriers and drivers across EU policies to achieve Climate-Smart Agriculture, AEIDL Policy Brief
Creators: name: Casares Guillén, Blanca
Publisher: name: Zenodo
Year: 2024
Subjects: Climate-Smart Agriculture
Behavioural Change
CAP

description: This AEIDL policy brief examines how existing EU policies contribute to behavioural change for more climate-smart agricultural practices. In the context of the upcoming post-2027 Common Agricultural Policy (CAP), the brief analyses 23 selected regulations and their compliance with the three key principles of Climate-Smart Agriculture (CSA): productivity, adaptation, and mitigation.

Drawing on findings from the Horizon Europe BEATLES project and linked to the ongoing Strategic Dialogue on the Future of EU Agriculture, the brief also identifies barriers and enablers to integrating CSA at the EU level. It aims to support policymakers by turning research into actionable recommendations for the next CAP reform and broader agri-food systems.
Passive spiral formation from halo gas starvation: Gradual transformation into S0s
Creators: name: Bekki, Kenji
name: Shioya, Yasuhiro
name: Couch, Warrick J.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent spectroscopic and high resolution $HST$-imaging observations have revealed significant numbers of ``passive'' spiral galaxies in distant clusters, with all the morphological hallmarks of a spiral galaxy (in particular, spiral arm structure), but with weak or absent star formation. Exactly how such spiral galaxies formed and whether they are the progenitors of present-day S0 galaxies is unclear. Based on analytic arguments and numerical simulations of the hydrodynamical evolution of a spiral galaxy's halo gas (which is a likely candidate for the source of gas replenishment for star formation in spirals), we show that the origin of passive spirals may well be associated with halo gas stripping. Such stripping results mainly from the hydrodynamical interaction between the halo gas and the hot intracluster gas. Our numerical simulations demonstrate that even if a spiral orbits a cluster with a pericenter distance $\sim$ 3 times larger than the cluster core radius, $\sim$ 80 % of the halo gas is stripped within a few Gyr and, accordingly, cannot be accreted by the spiral. Furthermore, our study demonstrates that this dramatic decline in the gaseous infall rate leads to a steady increase in the $Q$ parameter for the disk, with the spiral arm structure, although persisting, becoming less pronounced as the star formation rate gradually decreases. These results suggest that passive spirals formed in this way, gradually evolve into red cluster S0s.
description: 13 pages 4 figures (fig.1 = jpg format), accepted by ApJ
Acompsia subpunctella Svensson 1966
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Acompsia
Acompsia subpunctella

description: Acompsia subpunctella Svensson, 1966
Ajat river 03–05.VII.1997 (1♀).
 Distribution. Locally distributed in Sweden, Finland, the Baltic countries, NW Poland and Russia (Kola Peninsula, Karelia, Ural Mountains). Outside Europe in Altai and Transbaikalia (Huemer & Karsholt 2002).
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on page 65, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
Mañana será otro día
Creators: name: Merlino, Elena
Publisher: name: Zenodo
Year: 2025
Subjects: Calderón de la Barca; Métrica dramática; Segmentación dramática; Bibliografía; Mañana será otro día

description: Calderón Digital: base de datos, argumentos y motivos del teatro de Calderón (dir. Fausta Antonucci). Ficha dedicada a Mañana será otro día, con datos bibliográficos primarios y secundarios, fecha probable de composición, cómputo de las formas métricas, análisis de las coordenadas espacio-temporales, adscripción genérica y sinopsis argumental detallada, con indicación de los principales motivos (diegéticos y simbólicos) y propuesta de segmentación articulada según los cambios de forma métrica, de espacio y tiempo dramáticos.
Additional file 1 of Lung histopathological findings in COVID-19 disease – a systematic review
Creators: name: Pannone, Giuseppe
name: Caponio, Vito Carlo Alberto
name: De Stefano, Ilenia Sara
name: Ramunno, Maria Antonietta
name: Meccariello, Mario
name: Agostinone, Alessio
name: Pedicillo, Maria Carmela
name: Troiano, Giuseppe
name: Zhurakivska, Khrystyna
name: Cassano, Tommaso
name: Bizzoca, Maria Eleonora
name: Papagerakis, Silvana
name: Buonaguro, Franco Maria
name: Shailesh Advani
name: Muzio, Lorenzo Lo
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplemental Table 1 List of excluded studies and reason of exclusion.
Causal Interpretation and Quantum Phase Space
Creators: name: Dias, Nuno Costa
name: Prata, Joao Nuno
Publisher: name: arXiv
Year: 2001
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that the de Broglie-Bohm interpretation can be easily implemented in quantum phase space through the method of quasi-distributions. This method establishes a connection with the formalism of the Wigner function. As a by-product, we obtain the rules for evaluating the expectation values and probabilities associated with a general observable in the de Broglie-Bohm formulation. Finally, we discuss some aspects of the dynamics.
description: 13 pages, LaTex
Superoutbursts, superhumps and the tidal-thermal instability model
Creators: name: Buat-Menard, Valentin
name: Hameury, Jean-Marie
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We include the tidal instability due to the 3:1 resonance in the disc instability model developed by Hameury et al. (1998) and modified by Buat-Menard et al. (2001). We confirm earlier results by Osaki (1989) that the tidal instability can account for the SU UMa light curves. We show that in ultra-low mass ratio systems such as ER UMa stars and WZ Sge stars, the superoutburst ends while the disc is still eccentric, as proposed by Hellier (2001). However, since the disc shrinks rapidly once a cooling wave has started, the eccentricity should stop shortly after the end of a superoutburst. This result disagrees with the suggestion by Hellier that decoupling the thermal and tidal instability in the TTI model can account for late superhumps and echo outbursts in ultra-low mass ratio systems. We propose instead that ER UMa short supercycles can be explained either by the alternation of narrow and wide outbursts similar to those occurring in SS Cyg, or by the effects of irradiation (Hameury et al. 2000). In both cases, we predict that superhumps should be permanent, which is suggested by observations (Gao et al. 1999). We can also reproduce light curves similar to those of EG Cnc, varying the mass transfer rate in a TTI model including both irradiation and the presence of an inner hole in the disc.
description: Astronomy and Astrophysics, submitted. 8 pages, 5 figures
You can easily feel like a nobody: an interpretative phenomenological analysis of the lived experiences of 12 Chinese post-graduate students in higher education in the United Kingdom
Creators: name: Stoddart, Jonathan Mark
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Internationalisation
Higher Education
Chinese students
Post-graduate
Acculturation
Interpretative Phenomenological Analysis
University

description: Higher education in the UK has been transformed in diverse and far-reaching ways in recent decades, most notably through the internationalisation of the sector. Internationalisation has brought about many opportunities for states, institutions and individuals, but also raised concurrent challenges for all. Differences in approaches to knowledge and scholarship – cultures of learning ¬– have led international students, and post-graduate students from mainland China in particular, to be commonly conceptualised as deficient when they rub up against different practices in the UK. This thesis explores the experiences of 12 mainland Chinese post-graduate students across three higher education institutions in the UK. Data was generated through in-depth, focussed interviews, with the analysis drawing on the principles of Interpretative Phenomenological Analysis to generate a thematic, idiographic account of the participants’ lifeworlds. The interviews indicated that any satisfying outcomes of the participants’ sojourns were tempered by significant challenges, namely: establishing meaningful relationships with tutors and other students; feeling isolated, lonely and marginalised; struggling with emotional wellbeing; adjusting to new pedagogical practices and struggling with curricular content. In addition, transitioning to post-graduate study, and tense relationships between students from mainland China and those from Hong Kong and Taiwan, emerged as unexpected aspects of their lifeworlds. Given the range of challenges experienced by this cohort, this thesis draws on the emancipatory stances of neo-Marxism and critical transformative pedagogy to trouble current discourses. It militates for a reframing of the ways in which Chinese post-graduate students are conceptualised in higher education in the UK, which necessitates greater recognition and appreciation of the pluralithic approaches to knowledge and scholarship which are present in university classrooms. As this is a professional doctorate, suggestions for adjusting classroom practices, curricular content and institutional approaches are made, and I call for a deeper understanding of cultures of learning in university settings, for the benefit of all.
Coherent quasielastic neutron scattering and correlations between rotational jumps of molecules on a periodic lattice
Creators: name: Coddens, G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We previously derived a theorem about the {\em coherent} quasielastic neutron-scattering signal from a $d$-dimensional lattice of $N$ molecules that are undergoing rotational jump diffusion (around an $n$-fold axis), assuming that there are no correlations between the molecules. In the present paper molecular correlations are treated, but only in the sense that several molecules could reorient simultaneously as in a cog-wheel mechanism. Moreover, we do not examine the possibility that the relaxation times of these combined reorientations could depend on details of the local environment created by the neighbouring molecules. Finally also an ergodicity condition has to be fulfilled. Admitting for all these assumptions we can show that the correlations do not affect the coherent quasielastic scattering pattern in the following sense: The functions of $Q$ that intervene in the description of the intensities remain unaltered, while the functions of $ω$ can undergo a renormalization of the time scales. The latter changes cannot be detected as the time scales that would occur if the dynamics were independent are not available for comparison. In other words: Coherent quasielastic neutron scattering is not able to betray the existence of correlations of the restricted type that occur in our model.
description: 15 pages, 0 figures
A study of protein-DNA interactions using atomic force microscopy and DNA origami
Creators: name: Liu, Dandan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: restriction enzyme
DNA origami
atomic force microscopy
EcoRV
BcgI
quantitative studies
protein translocation
protein-DNA interaction
recognition site
recognition sites
translocation mechanism
protein-complex
Type II restriction enzymes
DNA-cutting

description: The development and application of genome editing tools has accelerated in recent years. However, their widespread application, especially in the medical field, is delayed for various issues with the safety of the tools being one of the top concerns. Much of the detail of how proteins find their target sites and how they cleave at the sites remains unclear. Despite much progress in lab environments, where the tolerance for imprecise cutting is relatively high, in vivo treatment remains difficult. Most genome editing tools are derived from naturally occurring regulatory proteins. Better understanding of the mechanisms used by these natural proteins should facilitate the use of genome editing tools. In nature, gene regulation is usually sparked by a change in the cellular environment, such as viruses invading a bacterium. Restriction enzymes defend the host bacteria by recognising specific sites on the viral DNA and cutting invading viruses at those sites. We aim first to understand how these proteins translocate along the viral DNA molecules toward their recognition sites, and then to see how their accuracy of cleavage can be increased. Protein translocation along DNA molecules has been studied for more than 40 years. Atomic force microscopy in fluid mode allows direct observation of protein/DNA interactions. This application is about twenty years old but most of the images taken, lack the spatial and temporal resolution for quantitative studies of protein translocation dynamics. Here we achieve second-level and nanometre-scale tracking of the translocation of EcoRV, a Type IIP restriction enzyme, using fast-scan atomic force microscopy (AFM) and DNA origami techniques. We find that EcoRV tends to jump toward its recognition site from afar and then switch to slow sliding mode when it is within about 20 base pairs of its recognition site. Our methods demonstrate how BcgI, a type IIB restriction enzyme, brings together two recognition sites both in cis and in trans before cleavage, minimising mis-cleavage at a single recognition site. We show that the collision looping model is valid but not the sliding model. The two restriction enzymes were chosen as they represent different model systems of typical restriction enzymes. Our methods will be useful in studies of other types of restriction enzymes and other proteins or protein complexes that interact with DNA. We expect that these methods will see broader applications in studies of protein-DNA interactions. We also hope that our studies will contribute to the safe application of the genome-editing tools in medical contexts.
description: Cambridge Trust
On Nonlinear Alfvén Waves Generated by Cosmic Ray Streaming Instability
Creators: name: Zirakashvili, V. N.
name: Ptuskin, V. S.
name: Völk, H. J.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Nonlinear damping of parallel propagating Alfvén waves in high-$β$ plasma is considered. Trapping of thermal ions and Coulomb collisions are taken into account. Saturated damping rate is calculated. Applications are made for cosmic ray propagation in the Galaxy.
description: 4 pages, LaTeX, published in Proc. 26th ICRC