cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bis-thiourea macrocycles incorporating fused [n]polynorbornanes: binding of flexible versus rigid dicarboxylates
Creators: name: Johnstone, Mark D.
name: Pfeffer, Frederick M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Two macrocyclic bis-thiourea hosts 5 and 6 were constructed and their interactions with two dicarboxylates of similar size (pimelate = flexible and terephthalate = rigid) were evaluated using 1H NMR titration techniques. In contrast to previous work with thiourea functionalised [n]polynorbornanes (where a notable increase in H:G affinity was noted for the rigid guest), the new macrocyclic hosts, in particular host 6, bind pimelate more strongly than terephthalate (for 6 binding pimelate log Ka = 4.7, terephthalate log Ka = 3.7). A binding arrangement in which the flexible dicarboxylate is ‘perched’ above the macrocycle is proposed to justify these results.
SPATIAL CORRELATION between DUST and Hα EMISSION in DWARF IRREGULAR GALAXIES
Creators: name: Jimmy
name: Tran, Kim Vy
name: Saintonge, Amélie
name: Accurso, Gioacchino
name: Brough, Sarah
name: Oliva Altamirano, Paola
name: Salmon, Brett
name: Forrest, Ben
Publisher: name: Swinburne
Year: 2024

description: Using a sample of dwarf irregular galaxies selected from the ALFALFA blind H i-survey and observed using the VIMOS IFU, we investigate the relationship between Hα emission and Balmer optical depth ({τ }{{b}}). We find a positive correlation between Hα luminosity surface density and Balmer optical depth in 8 of 11 at ≥0.8σ significance (6 of 11 at ≥1.0σ) galaxies. Our spaxels have physical scales ranging from 30 to 80 pc, demonstrating that the correlation between these two variables continues to hold down to spatial scales as low as 30 pc. Using the Spearman’s rank correlation coefficient to test for correlation between {{{Σ }}}{{H}α } and {τ }{{b}} in all the galaxies combined, we find ρ =0.39, indicating a positive correlation at 4σ significance. Our low stellar-mass galaxy results are in agreement with observations of emission line regions in larger spiral galaxies, indicating that this relationship is independent of the size of the galaxy hosting the emission line region. The positive correlation between Hα luminosity and Balmer optical depth within spaxels is consistent with the hypothesis that young star-forming regions are surrounded by dusty birth-clouds.Based on VLT service mode observations (Programs 081.B-0649 and 083.B-0662) gathered at the European Southern Observatory, Chile.
Trends in U.S. Soybean Acreage and Production, 1947-65
Creators: name: Kromer, George W.
name: Kromer, George W.
Publisher: name: Unknown
Year: 1965
Subjects: Agricultural and Food Policy
Crop Production/Industries
Land Economics/Use
Livestock Production/Industries
Productivity Analysis
Research and Development/Tech Change/Emerging Technologies

description: U.S. soybean acreage has nearly tripled in the postwar era, rising from around 12 million acres in 1947-49 to a record 34 million indicated for 1965. Important factors have been: (1) New varieties of soybeans better suited to both old and new production areas; (2) the shift of acreage formerly in oats to soybeans; (3) acreage restrictions on corn, wheat, and cotton; (4) the sharp expansion in market outlets for soybeans and products; and (5) favorable prices received by soybean producers. Rapid increases in the Delta, Lake, and other States have reduced the relative importance of the Corn Belt States from about 70 percent of the total U.S. soybean acreage in 1947-49 to 55 percent in 1965.
description: Reprinted from the Fats and Oils Situation, FOS-227, April 1965, by the Economic and Statistical Analysis Division, Economic Research Service
Design and simulation study of effective cooling channel for injection moulded plastic part
Creators: name: Abonassrya, Maitham
name: Saifullah, Abul
name: Alabid, Safaa
Publisher: name: Swinburne
Year: 2024

description: Injection moulding (IM) process has significant impact on plastic manufacturing process. In IM process cycle, cooling time carries almost half of its cycles time where cooling channel performance is one of the most crucial factors because it has significant effect on both production rate and the quality of the plastic part. With the advent of additive manufacturing, one of the effective way to address this issue is by manufacturing mould with conformal cooling which can control the uniform temperature distribution during plastic solidification process. This paper presents design and simulation study of conformal cooling channels and compare with conventional cooling for an industrial plastic part. Comparative study includes ejection temperature, shrinkage, temperature profile, and part warpage to determine which configuration is more appropriate to provide uniform cooling with minimum cycle time. Autodesk Simulation Moldflow Insight (ASMI) software is used to examine the results of the cooling channels performance.
Small-scale U.S. Goat Operations
Creators: name: , Animal
name: , Animal
Publisher: name: Unknown
Year: 2011
Subjects: subject: Farm Management
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business

description: Excerpts from the report: This is the third report in a series of reports resulting from the Small-scale Operations Initiative implemented by the National Animal Health Monitoring System (NAHMS) at the request of the administrator of the U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service. The primary objective of the Small-scale Operations Initiative is to investigate factors that set small-scale operations apart from larger operations. For this report, small-scale goat operations were defined as operations with fewer than 500 goats. Within U.S. livestock agriculture, farms with fewer than 500 goats are strong contributors to total goat production. Goats are important producers of meat, milk, fiber, and other products. However, goats are also raised or kept for a wider range of uses, such as brush control, livestock shows, packing, and as lively companions. About 4 of 10 small-scale goat operations (42.4 percent) focused primarily on meat production. One of 10 operations (10.0 percent) focused primarily on dairy production. Only 1.5 percent of operations focused primarily on fiber production, and 46.1 percent indicated that their primary production focus was “other,” i.e. goats used for brush control, pets, livestock shows, pack animals, or other uses.
description: Topic include: Production focus, Reasons for raising goats, Fiber marketing, Milk marketing, Kid marketing by meat goat operations, Goat health information sources, Zoonotic disease awareness, Biosecurity, Goat associations and club membership
Controlling the transmembrane transport of nucleosides
Creators: name: Peters, Gretchen Marie
name: Davis, Jeffery T.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: Nucleoside analogues are used as drugs. Due to their hydrophilicity, nucleosides are poorly permeable to membranes and transporter proteins are required for efficient uptake. One approach towards improving membrane permeability of nucleosides is to use synthetic transporters. We describe ways to control transport of nucleosides across a liquid membrane. Hexanoylguanosine 1 selectively extracts and transports cytidines across a CHCl3 membrane. Transport catalysed by G 1 was influenced by the nucleoside's sugar, with a selectivity of dC 4 > rC 3 > araC 5. Selective transport could be modulated by adding compounds to the aqueous source phase or to the organic phase. Addition of K+2,6-DNP–8 to CHCl3 containing G 1 switched off transport of rC 3 and dC 4 due to formation of a G-quartet assembly. A lipophilic G 1·C 2 base pair could not transport dC 4, but did catalyse transport of dG 7 across the CHCl3 barrier. We propose that transport occurs because of formation of a base triple G 1·C 2·dG 7. Addition of Na2B4O79 to a source phase containing rC 3, dC 4 and araC 5 shuts down transport of rC 3 by G 1, due to formation of borate esters. These results indicate that one can control the selective transport of nucleosides.
title: Paperbark and pinard
title: a cultural and historical exploration of female reproduction in one remote northern-Australian Aboriginal town
titleType: Subtitle
Creators: name: Ireland, Sarah
Publisher: name: Charles Darwin University
Year: 2015

description: Indigenous women in the Northern Territory of Australia experience significant reproductive and sexual health disadvantage, which widens with increasing geographical remoteness. Attempts to ameliorate this profound inequity, which have been based mostly on Western biomedical models of health care, have had limited efficacy in improving outcomes. Although an abundance of epidemiological data statistically substantiates Australian Indigenous women’s health disadvantage, a paucity of literature describes the contributing cultural contexts of Indigenous women’s health and even less privileges their experiences and perspectives on their reproductive health and gendered bodies. Set in an Australian remote town, this research aimed to historically contextualise women’s reproductive experiences and to document women’s cultural and linguistic constructions of reproduction. An ethnographic approach was used, which included historical and extended fieldwork over a six-year period, participant observations, written fieldwork diaries, reproductive ethnophysiology drawing and language sessions, semi-structured interviews, focus groups, archival document review, training and employment of Aboriginal research assistants, and consultation and advice from a local reference group and a cultural mentor. Women’s current emic perspectives and use of language to describe the female reproductive life cycle, anatomy and physiology are described and documented. The research findings demonstrate how changes to the local care of women during pregnancy and childbirth, which initially colonised ancestral reproductive practices, later nurtured women’s resilience. Planned locations for childbirth have undergone successive changes, with the only available option now being a regional hospital hundreds of kilometres away. Without robust evidence, scientific and clinical logics have been used to deny women their reproductive choices. This thesis suggest that women’s general health outcomes could be improved by a broad range of measures aimed at achieving better sexual and reproductive health rights for women.
Exploring 21 cm-Lyα Emitter Synergies for SKA
Creators: name: Hutter, Anne
name: Dayal, Pratika
name: Müller, Volker
name: Trott, Cathryn M.
Publisher: name: Swinburne
Year: 2024

description: We study the signatures of reionization and ionizing properties of early galaxies in the cross-correlations between the 21 cm emission from the spin-flip transition of neutral hydrogen (H i) and the underlying galaxy population. In particular, we focus on a sub-population of galaxies visible as Lyα Emitters (LAEs). With both observables simultaneously derived from a z ≃ 6.6 hydrodynamical simulation (GADGET-2) snapshot post-processed with a radiative transfer code (pCRASH) and a dust model, we perform a parameter study and aim to constrain both the average intergalactic medium (IGM) ionization state (1 -(XH1)) and the reionization topology (outside-in versus inside-out). We find that, in our model, LAEs occupy the densest and most-ionized regions resulting in a very strong anti-correlation between the LAEs and the 21 cm emission. A 1000 hr Square Kilometer Array (SKA)-LOW1 - Subaru Hyper Suprime-Cam experiment can provide constraints on (XH1) , allowing us to distinguish between IGM ionization levels of 50%, 25%, 10%, and fully ionized at scales r ≲ 10 comoving Mpc (assuming foreground avoidance for SKA). Our results support the inside-out reionization scenario where the densest knots (under-dense voids) are ionized first (last) for(XH1) ≳0.1. Further, 1000 hr SKA-LOW1 observations should be able to confirm the inside-out scenario by detecting a lower 21 cm brightness temperature (by about 2-10 mK) in the densest regions (≳2 arcmin scales) hosting LAEs, compared to lower-density regions devoid of them.
Pyridinium encapsulation within a novel cyano-footed pyrogallol[4]arene nanocapsule
Creators: name: Bowley, Neil D.
name: Funck, Muriel
name: Laventine, Dominic M.
name: Dalgarno, Scott J.
name: Cave, Gareth W.V.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: A novel polar solvent-soluble tetra-functionalised cyano-footed calixarene forms a dimeric capsule, sealed via a hydrogen-bonding network between the two macrocycles, a single water molecule and a chloride anion, resulting in the encapsulation of a pyridinium guest, as shown in both solution and the solid state.
A survey of self-organization mechanisms in multiagent systems
Creators: name: Ye, Dayong
name: Zhang, Minjie
name: Vasilakos, Athanasios V.
Publisher: name: Swinburne
Year: 2024

description: This paper surveys the literature over the last decades in the field of self-organizing multiagent systems. Self-organization has been extensively studied and applied in multiagent systems and other fields, e.g., sensor networks and grid systems. Self-organization mechanisms in other fields have been thoroughly surveyed. However, there has not been a survey of self-organization mechanisms developed for use in multiagent systems. In this paper, we provide a survey of existing literature on self-organization mechanisms in multiagent systems. We also highlight the future work on key research issues in multiagent systems. This paper can serve as a guide and a starting point for anyone who will conduct research on self-organization in multiagent systems. Also, this paper complements existing survey studies on self-organization in multiagent systems.
Amidst the Online Learning Modality: The Social Support and Its Relationship to the Anxiety of Senior High School Students
Creators: name: Basilio, Jastine Joy
name: Education, Psychology and
Publisher: name: figshare
Year: 2022
Subjects: subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: Developmental and Educational Psychology
subject: Education

description: Senior high school is known to be part of the newly implemented K-12 program in the Philippines' educational system. Hence, this program added two years to the academic learning program of students, which mainly focuses on different theoretical and vocational strands that aim to prepare and fully furnish the students for education and employment in the future. Due to adjustments to new online learning amidst the pandemic, students begin to experience various challenges, primarily social support and mental well-being. Hence, this study investigates the relationship between social support and anxiety with 160 respondents from private schools. The findings revealed that social support and anxiety have a significant relationship (r=0.126).
Le Point Ø, phénomène physique fondamental de la théorie du Livre.
Creators: name: Ouafae Lamraoui
Publisher: name: Zenodo
Year: 2023
Subjects: Physique
science
Théologie
Eschapsologie
singularité
trou de vers
équation
Livre

description: Selon la théorie du Livre, le Point Ø est un phénomène de physique théorique apparaissant lors de la période de Transition. Chainon manquant unifiant Mécanique quantique et Relativité générale à travers la conjonction des interactions fondamentales, il évoque un rebondissement marquant la fin d’un temps, au commencement d’un autre. L’Arch qui est un système de coordonnées astronomiques temporelles révèle le plan d’incidence du Point Ø. Contenant de la clef de la science, le Livre nous dit que ce point atteint la singularité gravitationnelle dans une boucle temporelle qui révèle à la fois le principe du phénomène physique α Alpha et la probabilité de l’univers Ω Oméga.

Ø = Θ(αΩ)
Supplemental Materials file for the manuscript, "Transitioning to a Green Economy: Radical Transformation or Building Upon Existing Skills?"
Creators: name: Shutters, Shade T
name: Lobo, José
Publisher: name: Zenodo
Year: 2022

description: Supplemental Materials file for the manuscript, "Transitioning to a Green Economy: Radical Transformation or Building Upon Existing Skills?" available in preprint form at https://ssrn.com/abstract=4097137
U.S. Meat Goat Operations
Creators: name: , Animal
name: , Animal
Publisher: name: Unknown
Year: 2012
Subjects: subject: Farm Management
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business

description: Excerpts from the report: The meat goat industry is one of the fastest growing segments of livestock production in the United States. The majority of all U.S. goats and kids are raised for meat. The rise in popularity and demand for goat meat is the primary reason for the industry’s rapid growth. The growing demand for goat meat reflects an increase in Hispanic, Middle Eastern, Southeast Asian, and Caribbean populations in the United States, as well as the growing niche markets interested in the unique flavor and health benefits of goat meat. These factors will likely continue to be the driving force for the U.S. meat goat industry. The NAHMS Goat 2009 study was the first national study of the U.S. goat industry and was conducted in 21 of the Nation’s major goat-producing States. These States represented 75.5 percent of U.S. goat operations and 82.2 percent of U.S. goats. Data for the study were collected from a stratified random sample of goat operations that kept at least one goat for meat, dairy, fiber, or other purposes.
description: Topics include feed and pasture management, breeding management, marketing, biosecurity and disease.
Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor
Creators: name: Scarr, E.
name: Udawela, M.
name: Thomas, E. A.
name: Dean, Brian
Publisher: name: Swinburne
Year: 2024

description: We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expression in the dorsolateral prefrontal cortex from two subgroups of subjects with schizophrenia, one with a marked deficit in muscarinic M1 receptors (muscarinic receptor-deficit schizophrenia (MRDS)), would identify different biochemical pathways that would be affected by their aetiologies. Hence, we measured levels of cortical (Brodmann area 9) mRNA in 15 MRDS subjects, 15 subjects with schizophrenia but without a deficit in muscarinic M1 receptors (non-MRDS) and 15 controls using Affymetrix Exon 1.0 ST arrays. Levels of mRNA for 65 genes were significantly different in the cortex of subjects with MRDS and predicted changes in pathways involved in cellular movement and cell-to-cell signalling. Levels of mRNA for 45 genes were significantly different in non-MRDS and predicted changes in pathways involved in cellular growth and proliferation as well as cellular function and maintenance. Changes in gene expression also predicted effects on pathways involved in amino acid metabolism, molecular transport and small-molecule biochemistry in both MRDS and non-MRDS. Overall, our data argue a prominent role for glial function in MRDS and neurodevelopment in non-MRDS. Finally, the interactions of gene with altered levels of mRNA in the cortex of subjects with MRDS suggest many of their affects will be upstream of the muscarinic M1 receptor. Our study gives new insight into the molecular pathways affected in the cortex of subjects with MRDS and supports the notion that studying subgroups within the syndrome of schizophrenia is worthwhile.
Validating reference genes using minimally transformed qpcr data: Findings in human cortex and outcomes in schizophrenia
Creators: name: Dean, Brian
name: Udawela, Madhara
name: Scarr, Elizabeth
Publisher: name: Swinburne
Year: 2024

description: Background: It is common practice, when using quantitative real time polymerase chain reaction (qPCR), to normalise levels of mRNA to reference gene mRNA which, by definition, should not vary between tissue, with any disease aetiology or after drug treatments. The complexity of human CNS means it unlikely that any gene could fulfil these criteria.
Methods: To address this issue we measured levels of mRNA for six potential reference genes (GAPDH, PPIA, SNCA, NOL9, TFB1M and SKP1) in three cortical regions (Brodmann’s areas (BA) 8, 9 and 44) from 30 subjects with schizophrenia and 30 age and sex matched controls. We used a structured statistical approach to examine the characteristics of these data to determine their suitability as reference genes. We also analysed our data using reference genes selected by rank as defined using the average of the standard deviation of pair-gene ΔCt and the BestKeeper, NormFinder and geNorm algorithms to determine if they suggested the same reference genes.
Results: Our minimally derived data showed that levels of mRNA for all of the six genes varied between cortical regions and therefore no gene fulfilled the absolute requirements for use as reference genes. As levels of some mRNA for some genes did not vary with diagnoses within a cortical region from subjects with schizophrenia compared to controls, we normalised levels of mRNA for all the other genes to mRNA for one, two or three reference genes in each cortical region. This showed that using the geometric mean of at least two reference genes gave more reproducible results. Finally, using the reference gene ranking protocols the average of the standard deviation of pair-gene ΔCt, BestKeeper, NormFinder and geNorm we showed that these approaches ranked potential reference genes differently. We then showed that outcomes of comparing data from subjects with schizophrenia and controls varied depending on the reference genes chosen.
Conclusions: Our data shows that the selection of reference genes is a significant component of qPCR study design and therefore the process by which reference genes are selected must be clearly listed as a potential confound in studying gene expression in human CNS. This should include showing that, using minimally derived qPCR data, levels of mRNA for proposed reference genes does not vary with variables such as diagnoses and CNS region.
Apartheid, l'intention en prémisse d'un crime contre l'humanité.
Creators: name: Lamraoui, Ouafae
Publisher: name: Zenodo
Year: 2023

description: Le mécanisme cérébral du libre-arbitre se construit en trois phases desquelles l'intention précède la prise de conscience. Dans la même logique un crime contre l'humanité suit un processus qui s'élabore sur une longue période de temps, mais dont les trois phases du libre-arbitre apparaissent distinctement jusqu'à ce que s'accomplisse le choix d'exécution volontaire du plan. Le tout, est de déterminer à quel moment s'établie l'intention et à quel moment le véto du libre-arbitre s'applique.
The topological and chemical implications of introducing oriented rings to [3]catenanes
Creators: name: Forgan, Ross S.
name: Blackburn, Anthea K.
name: Boyle, Megan M.
name: Schneebeli, Severin T.
name: J. Fraser Stoddart
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: We report the synthesis of three donor–acceptor azido-functionalised catenanes, wherein the asymmetric positioning of the azide group on one or two of the ring components renders its resident macrocycle constitutionally asymmetric, and so it acts as an oriented ring. As a consequence, the analyses of (i) a monoazido[2]catenane, (ii) a monoazido[3]catenane and (iii) a bisazido[3]catenane, which exists as a mixture of two conditional topological isomers, are significantly complicated. Accordingly, characterisation of the catenanes, which was achieved by a combination of dynamic 1H NMR spectroscopy, mass spectrometry and single crystal X-ray diffraction, is an arduous task. We expect that the difficulties in analysing these mechanically interlocked molecules will be encountered more frequently as chemists prepare entities with increasingly complex topologies.
Pyridinium encapsulation within a novel cyano-footed pyrogallol[4]arene nanocapsule
Creators: name: Bowley, Neil D.
name: Funck, Muriel
name: Laventine, Dominic M.
name: Dalgarno, Scott J.
name: Cave, Gareth W.V.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: A novel polar solvent-soluble tetra-functionalised cyano-footed calixarene forms a dimeric capsule, sealed via a hydrogen-bonding network between the two macrocycles, a single water molecule and a chloride anion, resulting in the encapsulation of a pyridinium guest, as shown in both solution and the solid state.
Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants
Creators: name: Gibbons, Andrew Stuart
name: Jeon, Won Je
name: Scarr, Elizabeth
name: Dean, Brian
Publisher: name: Swinburne
Year: 2024

description: BACKGROUND: Increasingly, data are implicating muscarinic receptors in the aetiology and treatment of mood disorders. This led us to measure levels of different muscarinic receptor-related parameters in the cortex from people with mood disorders and the CNS of rats treated with mood stabilisers and antidepressant drugs.
METHODS: We measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine. In addition, we used Western blots to measure levels of CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding as a measure of CHRM 2 / 4 signaling.
RESULTS: Compared with controls, [(3)H]AF-DX 384 binding was lower in BA 24 and BA 46 in bipolar disorders and major depressive disorders, while CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding was only lower in BA 24. Compared with vehicle, treatment with mood stabilisers, antidepressant drugs for 10 days, or imipramine for 28 days resulted in higher levels of in [(3)H]AF-DX 384 binding select regions of rat CNS.
CONCLUSIONS: Our data suggest that levels of CHRM2 are lower in BA 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region. Our data also suggest increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants.
Arbro-Esperanto, une langue universelle neutre pour promouvoir la paix des Nations.
Creators: name: Ouafae Lamraoui
Publisher: name: Zenodo
Year: 2024

description: A l’ère des Lumières, la création d’une langue internationale neutre est devenue indispensable pour faciliter les échanges intercommunautaires notamment les traductions multilingues d’ouvrages littéraires. Même si plusieurs projets de création de langues artificielles voient le jour entre la fin du 19ème et le début du 20ème siècle, l’Espéranto est la seule à aboutir. Cependant, après les deux Guerres Mondiales, l’organisation des échanges institutionnels entre les Nations est facteur de l’expansion d’un impérialisme linguistique dominant. L’anglais s’impose très vite dans les domaines économiques et culturels, jusqu’à devenir la langue de communication internationale. Aujourd’hui, les conflits d’intérêts unipolaires bouleversent les rapports pacifiques entre les peuples et impose le recours à une langue intermédiaire neutre pour équilibrer les relations mondiales.
Controlling the transmembrane transport of nucleosides
Creators: name: Peters, Gretchen Marie
name: Davis, Jeffery T.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Nucleoside analogues are used as drugs. Due to their hydrophilicity, nucleosides are poorly permeable to membranes and transporter proteins are required for efficient uptake. One approach towards improving membrane permeability of nucleosides is to use synthetic transporters. We describe ways to control transport of nucleosides across a liquid membrane. Hexanoylguanosine 1 selectively extracts and transports cytidines across a CHCl3 membrane. Transport catalysed by G 1 was influenced by the nucleoside's sugar, with a selectivity of dC 4 > rC 3 > araC 5. Selective transport could be modulated by adding compounds to the aqueous source phase or to the organic phase. Addition of K+2,6-DNP–8 to CHCl3 containing G 1 switched off transport of rC 3 and dC 4 due to formation of a G-quartet assembly. A lipophilic G 1·C 2 base pair could not transport dC 4, but did catalyse transport of dG 7 across the CHCl3 barrier. We propose that transport occurs because of formation of a base triple G 1·C 2·dG 7. Addition of Na2B4O79 to a source phase containing rC 3, dC 4 and araC 5 shuts down transport of rC 3 by G 1, due to formation of borate esters. These results indicate that one can control the selective transport of nucleosides.
Technology-infused science education curriculum for parents to teach kindergarten children
Creators: name: Ma, Ying
name: 0000-0002-5419-3624
Publisher: name: The University of Texas at Austin
Year: 2019
Subjects: Young children
Science education
Digital literacy
Education resources
Science lesson plans
Technology
Kindergarten

description: As technology advances and becomes an integral part of our life, concerns arise because of the inequity technology has unintendedly created especially reflected in the form of usage gap between different groups of learners and families. Parents who have young children and less knowledge of digital literacy and skills are suffering more from anxieties about children’s screen time and technology use at home. In terms of content area learning, there is a severe lack of quality science education resources for young children and that hinders children’s early exposure to science literacy. In this report, I reviewed research-based evidence for the need to develop technology-infused science education resources for parents of young children and then created a series of 10 lesson plans to help parents gain insights about technology integration for science learning at home for young kids and increase their confidence about the value of technology when used in content-rich ways
SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
Creators: name: Udawela, M.
name: Money, T. T.
name: Neo, J.
name: Seo, M. S.
name: Scarr, E.
name: Dean, Brian
name: Everall, I. P.
Publisher: name: Swinburne
Year: 2024

description: Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann’s Area (BA) 9, and to determine the disease specificity of increased SELENBP1 expression by measuring SELENBP1 mRNA in subjects with major depressive disorder and bipolar disorder. We then extended the study to include other cortical regions such as BA8 and BA44. SELENBP1 mRNA was higher in BA9 (P=0.001), BA8 (P=0.003) and BA44 (P=0.0007) from subjects with schizophrenia. Conversely, in affective disorders, there was no significant difference in SELENBP1 mRNA in BA9 (P=0.67), suggesting that the upregulation may be diagnosis specific. Measurement of SELENBP1 protein levels showed that changes in mRNA did not translate to changes in protein. In addition, chronic treatment of rats with antipsychotics did not significantly affect the expression of Selenbp1 in the cortex (P=0.24). Our data show that elevated SELENBP1 transcript expression is widespread throughout the prefrontal cortex in schizophrenia, and confirm that this change is a consistent feature of schizophrenia and not a simple drug effect.
Potential molecular and cellular mechanism of psychotropic drugs
Creators: name: Seo, Myoung Suk
name: Scarr, Elizabeth
name: Lai, Chi Yu
name: Dean, Brian
Publisher: name: Swinburne
Year: 2024

description: Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treat these disorders, they give sub-optimal recovery in many people and a significant number of individuals do not respond to any treatments and remain treatment resistant. Surprisingly, the mechanism by which psychotropic drugs cause their therapeutic benefits remain unknown but likely involves the underlying molecular pathways affected by the drugs. Hence, in this review, we have focused on recent findings on the molecular mechanism affected by antipsychotic, mood stabilizing and antidepressant drugs at the levels of epigenetics, intracellular signalling cascades and microRNAs. We posit that understanding these important interactions will result in a better understanding of how these drugs act which in turn may aid in considering how to develop drugs with better efficacy or increased therapeutic reach.
Observation des comportements sociodémographiques  au premier tour des Législatives 2024.
Creators: name: Lamraoui, Ouafae
Publisher: name: Zenodo
Year: 2024

description: Les résultats de ce premier tour de législatives anticipées, en plus de refaçonner un paysage politique à bout de souffle, est un indicateur des études sociodémographiques citoyennes. Dans ma circonscription qui totalise les votes de soixante-quatre communes, les résultats des quatre premiers partis donnent l’Union de l’extrême Droite à 35,41% ; Les Républicains à 25,41% ; l’Union des Gauches 23,25% et la majorité présidentielle Ensemble à 14,38%.

En observant ces résultats, je me suis interrogée sur les mécanismes qui pouvaient pousser des citoyens français à donner en masse leurs votes à un parti d’extrême droite alors même que les médias ont largement commenté la politique de suspicion que souhaite mener le Rassemblement National. Les propositions quand bien même inédites à l’encontre des binationaux n’a pas plus freiné l’ardeur des adhérents. Alors, appuyée des données publiées par le Ministère de l’Intérieur et des Outre-Mer, sur les résultats au premier tour de ces élections législatives, je me suis lancée dans une petite analyse de recherche. Sans trop entrer dans les détails, j’expose la démarche employée en prenant ma circonscription pour échantillon, ce que chacun pourra à son tour réaliser de son propre point de vue.
Amidst the Online Learning: The Self-Efficacy and Its Relationship to the Anxiety Among Senior High School Students
Creators: name: Ocbian, Janet
name: Education, Psychology and
Publisher: name: figshare
Year: 2022
Subjects: subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: Developmental and Educational Psychology
subject: Education
subject: 160809 Sociology of Education
subject: FOS: Sociology

description: Due to the school closures, all face-to-face education was halted, compelling institutions to rapidly transition to online learning. The approach to online learning may be challenging. The students' home learning environment was the most challenging impediment, whereas technical knowledge and skill presented the least difficulties. Thus, this study investigates the relationship between self-efficacy and anxiety among senior high school students in public schools amidst the online learning modality. Moreover, the statistical analysis manifested a significant relationship between self-efficacy and anxiety among senior high school students in implementing an online learning modality (r=.117).
Application of Markov Chain Models in Evaluating Workers Safety Performance in Power Distribution Company
Creators: name: Momoh Jimah and Queeneth Adesuwa Kingsley-Omoyibo
Publisher: name: Zenodo
Year: 2024

description: One of the riskiest industries in Nigeria is the power distribution sector. In addition, there has been less focus on worker, equipment, and work environment safety, thus this research work.  A six-year treatment record and a six-year safety kit cost obtained from Benin Distribution Electricity Company was used in this study. Markov chain model was used to evaluate incident records spanning seven (7) years that included medical care, fire incidents, near misses, risky conduct, and fatalities. The Markov chain model analytical tool revealed that before receiving actual medical attention or suffering a fatality, employees had, on average, engaged in seven (7) near-misses, risky acts, unsafe conditions, or fire occurrences. Workers who are involved in near-misses, unsafe acts, unsafe conditions, or fire incidents have a 0.04 probability of dying while working for the company; on the other hand, they have a 0.96 probability of being involved in an incident that requires medical attention.
Cholinergic connectivity: It's implications for psychiatric disorders
Creators: name: Scarr, Elizabeth
name: Gibbons, Andrew Stuart
name: Neo, Jaclyn
name: Udawela, Madhara
name: Dean, Brian
Publisher: name: Swinburne
Year: 2024

description: Acetylcholine has been implicated in both the pathophysiology and treatment of a number of psychiatric disorders, with most of the data related to its role and therapeutic potential focusing on schizophrenia. However, there is little thought given to the consequences of the documented changes in the cholinergic system and how they may affect the functioning of the brain. This review looks at the cholinergic system and its interactions with the intrinsic neurotransmitters glutamate and gamma-amino butyric acid as well as those with the projection neurotransmitters most implicated in the pathophysiologies of psychiatric disorders; dopamine and serotonin. In addition, with the recent focus on the role of factors normally associated with inflammation in the pathophysiologies of psychiatric disorders, links between the cholinergic system and these factors will also be examined. These interfaces are put into context, primarily for schizophrenia, by looking at the changes in each of these systems in the disorder and exploring, theoretically, whether the changes are interconnected with those seen in the cholinergic system. Thus, this review will provide a comprehensive overview of the connectivity between the cholinergic system and some of the major areas of research into the pathophysiologies of psychiatric disorders, resulting in a critical appraisal of the potential outcomes of a dysregulated central cholinergic system.
Cucurbit[6]uril dimer induces supramolecular polymerisation of a cationic polyethylene glycol derivative
Creators: name: Wittenberg, James B.
name: Isaacs, Lyle
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: Recently, we reported the synthesis of two new dimeric cucurbit[6]uril compounds (1 and 2). Herein, we describe the ability of compound 1 to undergo supramolecular polymerisation when combined with polyethylene glycol (PEG) derived divalent guests 3MW (MW = 300, 1000, 3350, 10,000). Interestingly, we find that the shorter PEG-derived guests 3300, 31000 and 33350 lead to low degrees of oligomerisation based on the diffusion coefficients obtained by diffusion-ordered spectroscopy measurements. In contrast, when 1 was combined with the longest PEG-derived guest 310,000, we observed the formation of a supramolecular polymer with a degree of oligomerisation of at least 36. We observe that the supramolecular polymer 1n·(310,000)n undergoes a slow decrease in its degree of oligomerisation to 22 over the course of 14 days controlled by the slow dissociation rate constant of the hexanediammonium unit of 310,000 from the CB[6]-sized cavity of 1.
Particularité du trouble de l'inhumanité : Conséquence sur l'ordre international et prévention du crime contre l'humanité.
Creators: name: Ouafae Lamraoui
Publisher: name: Zenodo
Year: 2024

description: Le trouble antisocial caractérise un comportement dénué de "conscience" émotionnelle. Largement étudié et expérimenté par la recherche, ce trouble neurodéveloppemental est l’antithèse des valeurs humanistes. N’étant toutefois ni facteur principal de criminalité ni facteur de causalité criminel, un individu caractérisé du trouble de la psychopathie accédant aux hautes fonctions gouvernementales est cependant facteur d’augmentation du risque de crime contre l’humanité. Etablir des mesures de préventions est dans l’intérêt des citoyens du monde pour le maintien d’un ordre mondial pacifique.
The topological and chemical implications of introducing oriented rings to [3]catenanes
Creators: name: Forgan, Ross S.
name: Blackburn, Anthea K.
name: Boyle, Megan M.
name: Schneebeli, Severin T.
name: J. Fraser Stoddart
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: We report the synthesis of three donor–acceptor azido-functionalised catenanes, wherein the asymmetric positioning of the azide group on one or two of the ring components renders its resident macrocycle constitutionally asymmetric, and so it acts as an oriented ring. As a consequence, the analyses of (i) a monoazido[2]catenane, (ii) a monoazido[3]catenane and (iii) a bisazido[3]catenane, which exists as a mixture of two conditional topological isomers, are significantly complicated. Accordingly, characterisation of the catenanes, which was achieved by a combination of dynamic 1H NMR spectroscopy, mass spectrometry and single crystal X-ray diffraction, is an arduous task. We expect that the difficulties in analysing these mechanically interlocked molecules will be encountered more frequently as chemists prepare entities with increasingly complex topologies.
Acrosaccus WILLARD 1928
Creators: name: Mergl, Michal
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Brachiopoda
Lingulata
Lingulida
Discinidae
Acrosaccus

description: Genus Acrosaccus WILLARD, 1928
 Type species. – Acrosaccus shuleri WILLARD, 1928; Upper Ordovician, Virginia, USA.
description: Published as part of Mergl, Michal, 2012, Lingulate And Craniate Brachiopods From The Top Of The Králův Dvůr Formation (Latest Katian) And Their Contribution To Palaeogeography, pp. 35-46 in Acta Musei Nationalis Pragae Series B 68 (1 - 2) on page 36, DOI: 10.5281/zenodo.13190994
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders
Creators: name: Tang, B.
name: Dean, Brian
name: Thomas, E. A.
Publisher: name: Swinburne
Year: 2024

description: Increasing evidence suggests that epigenetic factors have critical roles in gene regulation in neuropsychiatric disorders and in aging, both of which are typically associated with a wide range of gene expression abnormalities. Here, we have used chromatin immunoprecipitation-qPCR to measure levels of acetylated histone H3 at lysines 9/14 (ac-H3K9K14), two epigenetic marks associated with transcriptionally active chromatin, at the promoter regions of eight schizophrenia-related genes in n=82 postmortem prefrontal cortical samples from normal subjects and those with schizophrenia and bipolar disorder. We find that promoter-associated ac-H3K9K14 levels are correlated with gene expression levels, as measured by real-time qPCR for several genes, including, glutamic acid decarboxylase 1 (GAD1), 5-hydroxytryptamine receptor 2C (HTR2C), translocase of outer mitochondrial membrane 70 homolog A (TOMM70A) and protein phosphatase 1E (PPM1E). Ac-H3K9K14 levels of several of the genes tested were significantly negatively associated with age in normal subjects and those with bipolar disorder, but not in subjects with schizophrenia, whereby low levels of histone acetylation were observed in early age and throughout aging. Consistent with this observation, significant hypoacetylation of H3K9K14 was detected in young subjects with schizophrenia when compared with age-matched controls. Our results demonstrate that gene expression changes associated with psychiatric disease and aging result from epigenetic mechanisms involving histone acetylation. We further find that treatment with a histone deacetylase (HDAC) inhibitor alters the expression of several candidate genes for schizophrenia in mouse brain. These findings may have therapeutic implications for the clinical use of HDAC inhibitors in psychiatric disorders.
La Boucle du temps, rebond de la Super-énergie corollaire des interactions fondamentales. (Part2)
Creators: name: Ouafae Lamraoui
Publisher: name: Zenodo
Year: 2024
Subjects: Phisique
Science
Théologie
Eschapsologie
Temps
Super-énergie
Boucle du temps
Interactions fondamentales
Livre

description: Ce court article, qui vous laissera probablement sur votre faim, fait suite à la première partie de la Boucle du temps. Il est particulièrement dédié à la description de la Super-énergie provenant de la conjonction des interactions fondamentales observée dans la singularité du Point Ø. Les informations qu’il contient ne sont qu’une présentation première du phénomène qui sera plus techniquement étudié et analysé à travers l’œuvre en écriture du Bouleversement.
Hisingerella HENNINGSMOEN 1948
Creators: name: Mergl, Michal
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Brachiopoda
Lingulata
Acrotretida
Acrotretidae
Hisingerella

description: Genus Hisingerella HENNINGSMOEN, 1948
 Type species. –? Atrypa nitens VON HISINGER, 1837; Upper Ordovician, Sweden.
description: Published as part of Mergl, Michal, 2012, Lingulate And Craniate Brachiopods From The Top Of The Králův Dvůr Formation (Latest Katian) And Their Contribution To Palaeogeography, pp. 35-46 in Acta Musei Nationalis Pragae Series B 68 (1 - 2) on page 38, DOI: 10.5281/zenodo.13190994
The effect on simulated ocean climate of a parameterization of unbroken wave-induced mixing incorporated into the k-epsilon mixing scheme
Creators: name: Walsh, Kevin
name: Govekar, Pallavi
name: Babanin, Alexander
name: Ghantous, Malek
name: Spence, Paul
name: Scoccimarro, Enrico
Publisher: name: Swinburne
Year: 2024

description: A new parameterization of mixing processes in the upper ocean is tested in a 1/4° resolution global ocean climate model. The parameterization represents the effect of turbulent mixing by unbroken waves as an additional turbulent shear production term in the k-epsilon mixing scheme. The results show that the inclusion of this parameterization has a noticeable effect on ocean climate, particularly in regions of high wave activity such as the Southern Ocean. Inclusion of this process also leads to some reduction in the biases of the simulated climate, including mixed layer depth, compared with available observations.
Deliella HALAMSKI 2004
Creators: name: Mergl, Michal
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Brachiopoda
Craniata
Craniida
Craniidae
Deliella

description: Genus Deliella HALAMSKI, 2004
 Type species: Deliella deliae HALAMSKI, 2004; Middle Devonian, Germany.
description: Published as part of Mergl, Michal, 2012, Lingulate And Craniate Brachiopods From The Top Of The Králův Dvůr Formation (Latest Katian) And Their Contribution To Palaeogeography, pp. 35-46 in Acta Musei Nationalis Pragae Series B 68 (1 - 2) on page 42, DOI: 10.5281/zenodo.13190994
Towards ultra-stiff materials: Surface effects on nanoporous materials
Creators: name: Lu, Dingjie
name: Xie, Yi Min
name: Li, Qing
name: Huang, Xiaodong
name: Zhou, Shiwei
Publisher: name: Swinburne
Year: 2024

description: The significant rise in the strength and stiffness of porous materials at nanoscale cannot be described by conventional scaling laws. This letter investigates the effective Young's modulus of such materials by taking into account surface effect in a microcellular architecture designed for an ultralight material whose stiffness is an order of magnitude higher than most porous materials. We find that by considering the surface effects the predicted stiffness using Euler-Bernoulli beam theory compares well to experimental data for spongelike nanoporous gold with random microstructures. Analytical results show that, of the two factors influencing the effective Young's modulus, the residual stress is more important than the surface stiffness.