cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of two natural compound inhibitors of Leishmania donovani Spermidine Synthase (SpdS) through molecular docking and dynamic studies
Creators: name: Vidhya V., M.
name: Vikash Kumar Dubey
name: Karthe Ponnuraj
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Visceral leishmaniasis caused by the protozoan Leishmania donovani is the most severe form of leishmaniasis and it is potentially lethal if untreated. Despite the availability of drugs for treating the disease, the current drug regime suffers from drawbacks like antibiotic resistance and toxicity. New drugs have to be discovered in order to overcome these limitations. Our aim is to identify natural compounds from plant sources as putative inhibitors considering the occurrence of structural diversity in plant sources. Spermidine Synthase (SpdS) was chosen as the target enzyme as it plays a vital role in growth, survival, and due to its contribution in virulence. Our initial investigation started with a literature survey in identifying natural compounds that showed antileishmanial activity. Subsequently, we identified two monoterpenoid compounds, namely Geraniol and Linalool, that were structurally analogous to one of the substrates (putrescine) of SpdS. In the present study, homology model of L. donovani SpdS was generated and the binding affinity of the identified compounds was analyzed and also compared with the putrescine through molecular docking and dynamic studies. The pharmacokinetic properties of the identified compounds were validated and the binding efficiency of these ligands over the original substrate has been demonstrated. Based on these studies, Geraniol and Linalool can be considered as lead molecules for future investigations targeting SpdS. This study further emphasizes the choice of natural compounds as a good source of therapeutic agents.
Srčani puls, funkcije, estetika, dplyr paket i pretraga
Creators: name: Miljković, Nadica
Publisher: name: Zenodo
Year: 2023
Subjects: R programming
Rstats
function
dplyr
sleep study
pulse rate
IR measurement
coding standards
free software

description: Predavanje za predmet Tehnike obrade biomedicinskih signala na master akademskim studijama na Elektrotehničkom fakultetu Univerziteta u Beogradu.
Daily TV Use and Meaning in Life Among Older Adults. The Moderating Role of Selective and Compensatory TV Use
Creators: name: Hofer, Matthias
name: Birrer, Alena
name: Eden, Allison
name: Seifert, Alexander
Publisher: name: Routledge
Year: 2022
Subjects: subject: 300 - Sozialwissenschaften

description: Older adults (60+) spend a considerable amount of time watching TV. This can have important implications in terms of their daily sense of meaning in their life. Applying the selection, optimization, and compensation (SOC) model, we argue that the impact of the daily amount of time spent watching TV on daily perceptions of meaning in life is moderated by whether TV is generally used in a compensatory or selective manner. We present data from an intensive longitudinal study with N = 101 healthy older (60+) adults. Data were collected over five consecutive days. Compensatory and selective TV use were treated as a general strategy and thus as a trait-like variable measured in a baseline survey. Results show that the effect of the amount of daily television use on daily perceptions of meaning in life depends on the extent to which TV is generally used in a compensatory fashion as indicated by a cross-level interaction between compensatory TV use (between-person level 2) and daily self-reported TV use (within-person level 1) on daily perceptions of meaning in life. We discuss these findings in terms of both theoretical and methodological considerations.
Fabrication of NiFe2O4 magnetic nanoparticles loaded on activated carbon as novel nanoadsorbent for Direct Red 31 and Direct Blue 78 adsorption
Creators: name: Livani, Milad Jamal
name: Ghorbani, Mohsen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: In this research, magnetic nickel ferrite NiFe2O4/hazelnut-shell-based activated carbon (NiFe2O4/AC) was used to eliminate anionic dyes (Direct Red 31(DR31) and Direct Blue 78 (DB78)) from aqueous solution. The morphological, structural, particle size and surface charge properties of as-prepared nanoadsorbent were characterized. TEM (Transmission electron microscopy) images revealed that the size of NiFe2O4 particles in the structure of AC was in the range of 8-12 nm, which is compatible with the results obtained by the analysis of DLS (Dynamic light scattering). The results of the BET (Brunauer–Emmett–Teller) analysis indicated that the surface area, the pore volume and average pore diameters of the NiFe2O4 were 288 m2/g, 0.3338 cm3/g and 5.05nm, respectively. The as-prepared nanocomposite showed excellent adsorption capacity for DR31 and DB78 dyes with the highest adsorption capacity obtained at pH=2.0 and rapid dye adsorption equilibrium attained after 20 and 25 min for DR31 and DB78, respectively. The equilibrium study showed the maximum adsorption capacity (qmax) of 299.67 mg/g and 209.13 mg/g for DR31 and DB78, respectively. In addition, thermodynamic study revealed the endothermic and spontaneous nature of adsorption process. The adsorption of DR31 and DB78 onto the NiFe2O4/AC is a physisorption process, during which electrostatic adsorption was the main driving force.
[Puchita : La poesía es tan audaz como el más tiznado de los capitanes
Creators: name: Manuel, Vázquez Portal
name: Vázquez Portal, Manuel
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Prison de Boniato
Poésie

description: Destinataire : Huerga Cedeño, Yolanda
description: Description : Lettre de Vázquez Portal à son épouse. L'auteur évoque sa nécessité d'écrire de la poésie. La lettre est accompagnée de deux poèmes, écrits en avril 2004 : 'Variaciones de una glosa' et 'Comer por separado'. Il suggère que le premier poème soit associé au poème intitulé 'Lomaciega', et le second à 'Poema celular' pour leur publication.
description: Notes : Avec son enveloppe. Lettre envoyée depuis la Prison de Boniato, 'Celda n° 9'. Le cachet de la poste au recto comporte la date 12-04-2004. Sur les trois cachets au verso deux sont illisibles, le troisième comporte la date 12-04-2004. Adresse figurant sur l'enveloppe : 'Edificio 979 apto 14 – Zona 24. Alamar – Habana del Este – Ciudad de la Habana – Cuba'.
description: Source: Cote : MVP-B-2004-04-12
description: Source: Localisation du document : États-Unis, Miami (Floride)
Zehn Jahre geodätisches Grundlagen- und Überwachungsnetz im Felslabor Mont Terri: Präzisions-Tunnelvermessung für die Entwicklung und Austestung eines Überwachungskonzepts für zukünftige Tiefenlager
Creators: name: Kistler, Matthias
name: Mahler, Peter
name: Schefer, Senecio
name: Condamin, Sebastian
Publisher: name: Wichmann
Year: 2017
Subjects: subject: Tunnelvermessung
subject: Deformationsvermessung
subject: geologische Tiefenlager
subject: Mont Terri
subject: 500 - Naturwissenschaften
subject: 624 - Ingenieurbau und Umwelttechnik

description: Im Felslabor Mont Terri in St - Ursanne wird seit 1996 ein internationales Forschungsprogramm durchgeführt mit dem Ziel, die spezifischen Eigenschaften des Opalinustons hinsichtlich Machbarkeit und Sicherheit eines geologischen Tiefenlagers für radioaktive Abfälle abzuklären. Ein seit 2007 laufend weiter entwickeltes, hochpräzises geodätisches Grundlagen- und Deformationsnetz bietet die Basis, um kleinste dreidimensionale Veränderungen bedingt durch natürliche und/oder künstlich (durch Bauprojekte und Experimente) erzeugte Veränderungen zu detektieren; zudem sollen geochemische und geotechnische Sensoren damit georeferenziert werden. Der vorliegende Artikel beschreibt die in den letzten 10 Jahren durchgeführten Arbeiten und dokumentiert die erreichten Resultate und Erkenntnisse.
title: METEOR Studie: Analyse des Gesamtüberlebens (OS) basierend auf der frühen Tumorvolumenreduktion (eTS) in der Phase III Studie von Cabozantinib (Cabo) versus Everolimus (Eve) beim fortgeschrittenen Nierenzellkarzinom (RCC)
Creators: name: Goebell, P.
name: Duran, I.
name: Maroto, P.
name: Suarez, C.
name: Castellano, D.
name: García del Muro, X.
name: Costa, L.
name: Martin-Couce, L.
name: Benzaghou, F.
name: Thomas, S.
name: Markby, D.
name: Choueiri, T.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Kann bei RCC Patienten (Pt) eine höhere eTS-Rate mit einem verlängerten medianen OS assoziiert werden? Einleitung und Ziel: In der Phase 3 Studie METEOR (NCT01865747) verbesserte Cabo signifikant das OS (median 21,4 vs 16,5 Monate (Mo); HR, 0,66; 95% CI, 0,53–0,83),[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Cyanide poisoning in Thailand before and after establishment of the National Antidote Project*
Creators: name: Sahaphume Srisuma
name: Aimon Pradoo
name: Panee Rittilert
name: Sunun Wongvisavakorn
name: Achara Tongpoo
name: Charuwan Sriapha
name: Wannapa Krairojananan
name: Netnapis Suchonwanich
name: Sumana Khomvilai
name: Winai Wananukul
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Space Science
Medicine
Neuroscience
Cancer
Science Policy
Computational Biology

description: Context: Antidote shortage is a global problem. In Thailand, the National Antidote Project (NAP) has operated since November 2010 to manage the national antidote stockpile, educate the healthcare providers on appropriate antidote use, and evaluate antidote usage. Objective: To evaluate the effect of NAP implementation on mortality rate and antidote use in cyanide poisoning cases arising from ingestion of cyanide or cyanogenic glycoside. Methods: This is a retrospective cohort of poisoning cases involving cyanide or cyanogenic glycoside ingestion reported to Ramathibodi Poison Center from 1 January 2007 to 31 December 2015. Mortality rate, antidote use, and appropriateness of antidote use (defined as correct indication, proper dosing regimen, and administration within 90 min) before and after NAP implementation were compared. Association between parameters and fatal outcomes was analyzed. Results: A total of 343 cases involving cyanide or cyanogenic glycoside ingestion were reported to Ramathibodi Poison Center. There were 213 cases (62.1%) during NAP (Project group) and 130 cases (37.9%) pre-NAP implementation (Before group). Implementation of NAP led to increased antidote use (39.9% in Project group versus 24.6% in Before group) and a higher rate of appropriate antidote use (74.1% in Project group versus 50.0% in Before group). All 30 deaths were presented with initial severe symptoms. Cyanide chemical source and self-harm intent were associated with death (OR: 12.919, 95% CI: 4.863–39.761 and OR: 10.747, 95% CI: 3.884–28.514, respectively). No difference in overall mortality rate (13 [10.0%] deaths before versus 17 [8.0%] deaths after NAP) was found. In subgroup analysis of 80 cases with initial severe symptoms, NAP and appropriate antidote use reduced mortality (OR: 0.327, 95% CI: 0.106–0.997 and OR: 0.024, 95% CI: 0.004–0.122, respectively). In the multivariate analysis of the cases with initial severe symptoms, presence of the NAP and appropriate antidote use independently reduced the risk of death (OR: 0.122, 95% CI: 0.023–0.633 and OR: 0.034, 95% CI: 0.007–0.167, respectively), adjusted for intent of exposure, cyanide source, age, and sex. Conclusions: After NAP implementation, both antidote use and appropriate antidote use increased. In cases presenting with severe symptoms, presence of the NAP and appropriate antidote use independently reduced the risk of mortality.
Additional file 3 of HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma
Creators: name: He, Song
name: Ding, Yu
name: Ji, Zhonghao
name: Yuan, Bao
name: Chen, Jian
name: Ren, Wenzhi
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 3
title: Hilfestellung zur sinnvollen Indikation der Metastasektomie bei metachron metastasierten Nierenzellkarzinompatienten
Creators: name: Seles, M.
name: Maisel, F.
name: Smolle, M. A.
name: Molnar, S.
name: Riedl, J. M.
name: Barth, D.
name: Terbuch, A.
name: Rossmann, C. H.
name: Mannweiler, S.
name: Hutterer, G. C.
name: Zigeuner, R.
name: Pummer, K.
name: Smolle-Jüttner, F.-M.
name: Lindenmann, J.
name: Stotz, M.
name: Gerger, A.
name: Stöger, H.
name: Pichler, M.
name: Posch, F.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Metastasektomie stellt ein mögliches Verfahren in der Behandlungskaskade des metastasierten Nierenzellkarzinoms als Alternative zu systemischen Therapien wie Checkpoint- und/oder Tyrosinkinaseinhibitoren dar. Diese Behandlungsoption kann Patienten mitunter lang andauernde Remissionen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Cytotoxicity, In vitro anti-Leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum
Creators: name: Khan, Kashif Maqbool
name: Lutfun Nahar
name: Mannan, Abdul
name: Ul-Haq, Ihsan
name: Arfan, Muhammad
name: Khan, Ghazanfar Ali
name: Hussain, Izhar
name: Sarker, Satyajit D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plant Biology

description: Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae), commonly known as ‘nagchhatry’ or ‘teen patra’, distributed from Pakistan to Bhutan about 2500–3800 m altitude is indigenous to Himalayas region. In folk medicine the plant has been reported for the treatment of wound healing, sepsis and in various sexual disorders. This paper reports, for the first time, to evaluate the cytotoxicity, in vitro anti-leishmanial (promastigotes) and fingerprint HPLC-photodiode array analysis of the MeOH extract of the roots of T. govanianum and its solid phase extraction fractions. Reverse phase HPLC-PDA based quantification revealed the presence of significant amount of quercetin, myrecetin and kaemferol ranging from 0.221to 0.528 μg/mg DW. MeOH extract revealed distinguishable protein kinase inhibitory activity against Streptomyces 85E strain with 18 mm bald phenotype. The remarkable toxicity profile against brine shrimps and leishmanial was manifested by MeOH extract with LC50 10 and 38.5 μg/mL, respectively.
Pflegearrangements und Einstellung zur Spitex bei Migrantinnen und Migranten in der Schweiz
Creators: name: Kohn, Johanna
name: Tov, Eva
Publisher: name: Hochschule für Soziale Arbeit FHNW
Year: 2013
Subjects: subject: 360 - Soziale Probleme, Sozialdienste, Versicherungen

description: Die vorliegende Studie beschäftigt sich mit den Fragen, welche Haltungen betagte Migrantinnen und Migranten und Pflegende Angehörige zu Pflege und Unterstützungsleistungen haben, welche Pflegearrangements bei ihnen typisch sind, welche Erfahrungen sie damit machen und inwieweit sie die Angebote im Gesundheitsbereich, insbesondere die Spitex-Dienste, nutzen.
Social and regional factors predict the likelihood of admission to a nursing home after acute hospital stay in older people with chronic health conditions. A multilevel analysis using routinely collected hospital and census data in Switzerland
Creators: name: Bachmann, Nicole
name: Zumbrunn, Andrea
name: Bayer-Oglesby, Lucy
Publisher: name: Frontiers
Year: 2022
Subjects: subject: SIHOS
subject: Social Work
subject: FOS: Sociology
subject: Hospital
subject: old age
subject: chronic health conditions
subject: hospital discharge
subject: nursing home
subject: social inequality
subject: 360 - Soziale Probleme, Sozialdienste, Versicherungen

description: If hospitalization becomes inevitable in the course of a chronic disease, discharge from acute hospital care in older persons is often associated with temporary or persistent frailty, functional limitations and the need for help with daily activities. Thus, acute hospitalization represents a particularly vulnerable phase of transient dependency on social support and health care. This study examines how social and regional inequality affect the decision for an institutionalization after acute hospital discharge in Switzerland. The current analysis uses routinely collected inpatient data from all Swiss acute hospitals that was linked on the individual level with Swiss census data. The study sample included 60,209 patients 75 years old and older living still at a private home and being hospitalized due to a chronic health condition in 199 hospitals between 2010 and 2016. Random intercept multilevel logistic regression was used to assess the impact of social and regional factors on the odds of a nursing home admission after hospital discharge. Results show that 7.8% of all patients were admitted directly to a nursing home after hospital discharge. We found significant effects of education level (compulsory vs. tertiary education OR = 1.16 (95% CI: 1.03–1.30), insurance class (compulsory vs. private insurance OR = 1.24 (95% CI: 1.09–1.41), living alone vs. living with others (OR = 1.64; 95% CI: 1.53–1.76) and language regions (French vs. German speaking part: OR = 0.54; 95% CI: 0.37–0.80) on the odds of nursing home admission in a model adjusted for age, gender, nationality, health status, year of hospitalization and hospital-level variance. The language regions moderated the effect of education and insurance class but not of living alone. This study shows that acute hospital discharge in older age is a critical moment of transient dependency especially for socially disadvantaged patients. Social and health care should work coordinated together to avoid unnecessary institutionalizations.
Additional file 1 of Changes in terpene biosynthesis and submergence tolerance in cotton
Creators: name: Sun, Liangqing
name: Wang, Junjuan
name: Cui, Yupeng
name: Cui, Ruifeng
name: Kang, Ruiqing
name: Zhang, Yuexin
name: Wang, Shuai
name: Zhao, Lanjie
name: Wang, Delong
name: Lu, Xuke
name: Fan, Yapeng
name: Han, Mingge
name: Chen, Chao
name: Chen, Xiugui
name: Guo, Lixue
name: Ye, Wuwei
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1.
Design of competitive light-weight composite materials: SiC/TiSi2
Creators: name: Giuranno Donatella
name: Novakovic Rada
name: Nowak Rafal
name: Petrin Dmytro
name: Polkowski Wojciech
name: Marta, Homa
name: Bruzda Grzegorz
name: Kudyba Artur
name: Javier, Narciso
name: Sobczak Natalia
Publisher: name: Zenodo
Year: 2018

description: POSTER PRESENTATION Thermo-mechanical resistant light-weighting materials open new frontiers in designing and assembling transportation systems, from ground to space (aircraft, high-speed trains, satellites, etc). Currently, few and no-commercial new materials are suitable for such kind of highly demanding applications. To find less-costly alternatives, R&D is highly focused on advanced refractories and composites, i.e. MMC and CMC-types where the metal phase is an Al, Si or Ti-based alloy and SiC the reinforcement. Reactive Infiltration processes have well known advantages over other conventional sintering and hot-pressing techniques, i.e. lower processing temperatures, shorter times and near-net shape fabrication capabilities. Many aspects are not fully understood related to interfacial phenomena occuring during the infiltration process, making difficult both to decrease the unreacted Si (affecting thermo-mechanical resistance) and to “control” the “pore closure” phenomenon. The ad-hoc selection of a Si-Me alloy as infiltrating phase of C- or SiC/C-preforms to obtain a SiC/Me-Silicide composite with improved thermo-mechanical properties is one of the winning strategies.
 Key contributions could be coming from know-how on wetting characteristics, reactivity, surface properties and thermodynamics concerning reacting phases. Aiming to successfully fabricate SiC/TiSi2 composite by reactive infiltration, an all-round investigation on thermodynamics, wettability and infiltration of Si-Ti/C and Si-Ti/SiC couples is on going in the framework of “SIC-WIN: Reactivity of SI-alloy/C-material system: Wetting vs Infiltration" Project, H2020-MCSA, POLONEZ-3 and some results are here presented.
description: The NCN-National Science Center, Poland is greatly acknowledged for the financial support through the POLONEZ project number UMO-2016/23/P/ST8/01916. This project was carried out under POLONEZ-3 program which has received funding from European Union's Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement. No 665778.
Additional file 4 of Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Creators: name: Ruan, Peifeng
name: Todd, Jamie L
name: Zhao, Hongyu
name: Liu, Yi
name: Vinisko, Richard
name: Soellner, Julia F.
name: Schmid, Ramona
name: Kaner, Robert J.
name: Luckhardt, Tracy R.
name: Neely, Megan L.
name: Noth, Imre
name: Porteous, Mary
name: Raj, Rishi
name: Safdar, Zeenat
name: Strek, Mary E
name: Hesslinger, Christian
name: Palmer, Scott M.
name: Leonard, Thomas B.
name: Salisbury, Margaret L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 4: Section S3. Differential expression analyses.
title: Einfluss der BCG-Instillationstherapie auf die diagnostische Aussagekraft der Urinzytologie bei der Detektion von high-grade Harnblasenkarzinomen
Creators: name: Hermans, J.
name: Schulz, G.
name: Pfitzinger, P.
name: Jokisch, F.
name: Ziegelmüller, B.
name: Westhofen, T.
name: Mumm, J.-N.
name: Eismann, L.
name: Strittmatter, F.
name: Stief, C.
name: Tritschler, S.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Die Urinzytologie ist fester Bestandteil der leitliniengerechten Nachsorge des high-grade nichtmuskelinvasiven Harnblasenkarzinoms (NMIBC). Therapeutisch kommt der BCG-Instillationstherapie beim NMIBC eine bedeutende Rolle zu. Da BCG-vermittelte Entzündungen morphologische Veränderungen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Large-Scale Indoor Tracking
Creators: name: Krebs, Matthias Christian
name: Stamm, Christoph
name: Resch, Thomas
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2013
Subjects: subject: Soundwalk
subject: Indoor Positioning
subject: Lokalisierungstechnik
subject: kamerabasiertes Tracking
subject: Navigation
subject: 005 - Computer Programmierung, Programme und Daten
subject: 770 - Fotografie, Video, Computerkunst

description: Im Projekt „Large-Scale Indoor Tracking in transitorischen Räumen“ schliessen sich drei Forschungsinstitute von drei verschiedenen Teilschulen der FHNW mit externen Künstlern zusammen, um gemeinsam neue Trackingverfahren für ein interaktives Kunstwerk zu entwickeln. Der daraus entstandene interaktive Soundwalk „LautLots“ wurde im September 2013 im Badischen Bahnhof in Basel uraufgeführt. Die technischen Zielsetzungen, Hintergründe und Ergebnisse dieses Soundwalks werden in diesem Beitrag beleuchtet.
International Trade Disciplines and Policy Measures to Address Climate Change Mitigation and Adaptation in Agriculture
Creators: name: Blandford, David
name: Blandford, David
Publisher: name: Unknown
Year: 2013
Subjects: International Relations/Trade
Agricultural and Food Policy

description: An increasing concentration of greenhouse gases (GHGs) in the atmosphere is believed to be contributing to global warming. Agriculture is a significant contributor to GHG emissions through crop and animal production and land clearance, but it can also recycle and sequester atmospheric carbon. Climate change has major implications for global agriculture. Efforts will be made to mitigate GHG emissions by the agricultural sector and to increase its role in removing carbon from the atmosphere. Changes in temperature and rainfall patterns and greater climatic instability are problems that the sector will have to adapt to. Policies to promote mitigation and adaptation may be driven by domestic political concerns or by international climate agreements. The use of policy instruments for agriculture in response to climate change poses challenges for the international trading system. The extent change policies could become a guise for protecting domestic food and agricultural sectors from international competition. An important issue that has to be addressed is what modifications need to be made to allow countries to achieve their objectives while, at the same time, preventing undue restrictions on trade. There is a potential for a clash with WTO trade rules depending reached on the issues and suitable approaches if the possibility for future conflict between climate policies and trade policies is to be reduced.
Post-print: World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain? DOI: 10.1097/01.j.pain.0000460356.94374.a1
Creators: name: Kamerman, Peter
name: Wadley, Antonia
name: KAREN DAVIS
name: Hietaharju, Aki
name: Parmanand Jain
name: Kopf, Andreas
name: Ana-Claire Meyer
name: Raja, Srinivasa
name: Rice, Andrew
name: Smith, Blair
name: Rolf-Detlef Treede
name: Wiffen, Phillip
Publisher: name: figshare
Year: 2017
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Post-print copy of: Kamerman PR, Wadley AL, Davis KD, Hietaharju A, Jain P, Kopf A, Meyer A-C, Raja SN, Rice ASC, Smith BH, Treede R-D, Wiffen PJ. World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain? PAIN 156: 793–797, 2015. DOI: 10.1097/01.j.pain.0000460356.94374.a1, PMID: 25894010
Data and analysis scripts: 10.6084/m9.figshare.4644412.v4
Abstract: No abstract available.
L'écosystème des identifiants : jungle ou jardin à la française ?
Creators: name: Bober, Benjamin
name: Melzac, Carole
Publisher: name: Zenodo
Year: 2024

description: Journées Abes 2024

D’après Wikidata, il existe 1 342 identifiants de personnes, 424 identifiants d’organisations, 320 identifiants de lieux géographiques… Dans cette jungle d’identifiants, certains sont plus structurants que d’autres, certains sont plus ouverts que d’autres, mais tous répondent à des besoins spécifiques.  La future base centrale de métadonnées préfigurée dans le projet d’établissement devra continuer à s’interconnecter à d’autres référentiels externes afin de consolider son offre de service.Cette session sera l’occasion de dresser un panorama de cet écosystème complexe et s’attachera à présenter les travaux menés à l’Abes dans et autour d’IdRef enélargissant la focale au paysage international, notamment via les identifiants ROR et ORCID.
title: RACE IT – eine prospektive, multizentrische, einarmige Phase-II Studie zur Durchführung einer präoperativen Strahlentherapie in Kombination mit Immuntherapie gefolgt von radikaler Zystektomie beim lokal fortgeschrittenen Harnblasenkarzinom
Creators: name: Koll, F. J.
name: Beckert, F.
name: Rödel, C.
name: Maisch, P.
name: Sauter, A.
name: Seitz, A.
name: Kübler, H.
name: Flentje, M.
name: Chun, F.
name: Combs, S.
name: Schiller, K.
name: Gschwend, J. E.
name: Retz, M.
name: Schmid, S. C.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Rationale: Patienten mit lokal fortgeschrittenen Blasentumoren (cT3/4 cN0/N+ cM0) haben trotz radikaler chirurgischer Therapie und perioperativer Chemotherapie eine schlechte Prognose. Beim metastasierten Blasenkarzinom hat die Wirksamkeit von Immuncheckpoint-Inhibitoren (Anti-PD1/PDL1)[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Do Yesterday's Disciplines Fit Today's Farm Trade? Challenges and Policy Options
Creators: name: Bureau, Jean-Christophe
name: Jean, Sébastien
name: Bureau, Jean-Christophe
name: Jean, Sébastien
Publisher: name: Unknown
Year: 2013
Subjects: International Relations/Trade
Agricultural and Food Policy

description: This piece explores how trade and trade policies have evolved over the last decade and considers the possible implications for the multilateral trading system. Since the Doha Round was launched, the importance of developing countries in world trade of agricultural products has increased dramatically. World markets are seeing higher prices, after trending downward for decades. The development of biofuels has had considerable impact on price levels and market adjustment mechanisms, with the risk of rigidifying crop demand. There has been a downward trend in applied tariffs as a result of unilateral liberalizations as well as regional trade agreements. Despite a number of recent protectionist measures, the current economic crisis has not reversed this trend. Nontariff measures have also spread, especially in emerging countries, and the proliferation of regional trade agreements has influenced international trade patterns. After the 1994 Marrakesh Agreement, many developed countries reduced the most distorting forms of agricultural support, but recent policy decisions have reversed this trend. Several emerging countries have increased their subsidies to farmers. In addition, some of the disciplines introduced by the 1994 Marrakesh Agreement have lost their efficacy. While export subsidies and related distortions on the world market have shrunk, export restrictions have become more common. Against this background, we argue that the negotiations should be refocused and, in some cases, rescaled. Doha Round negotiators may have overplayed their hand by understating the cost of failure: scaling down ambition may help in reaching an agreement.
Baicalin induces apoptosis in human osteosarcoma cell through ROS-mediated mitochondrial pathway
Creators: name: Daqian Wan
name: Huoniu Ouyang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Baicalin is extracted from a traditional Chinese herb, Scutellaria baicalensis. In this study, the anticancer activity and underlying mechanisms of baicalin towards human osteosarcoma cell (HOS) were investigated. Baicalin could inhibit HOS cell proliferation in a concentration-dependent manner. Mitochondrial membrane potential decreased obviously after treated with different concentration of baicalin by flow cytometry assay and revealed that baicalin triggered a significant generation of reactive oxygen species (ROS). Western blotting assay further revealed that baicalin-induced cell apoptosis by suppressing Bcl-2 level, then activating caspase-9 and caspase-3. In vivo experiment, baicalin significantly suppressed tumour growth in female BALB/C nude mice bearing HOS tumours. In addition, baicalin did show toxicity to treated animal by comparing the body weight increase and mortality. In general, the present results demonstrated that baicalin-induced apoptosis in human osteosarcoma cell via a ROS-mediated mitochondrial pathway. The paper indicated that baicalin is a promising candidate for the treatment of HOS.
Trade and Food Security
Creators: name: Chatterjee, Bipul
name: Murphy, Sophia
name: Chatterjee, Bipul
name: Murphy, Sophia
Publisher: name: Unknown
Year: 2013
Subjects: International Relations/Trade
Food Security and Poverty

description: The evolving food security agenda offers governments a chance to address some urgent concerns and strengthen the multilateral trade system. The Doha Agenda has been overtaken by time and events. Many of the lessons for food security of the past decade point to the need for new rules. International markets have seen three food commodity price spikes, and the financial collapse of 2008 and the resulting turmoil in international trade and financial markets has left its mark. Governments have been reluctant at the World Trade Organization to confront the implications of these changes. Many developed countries are advocating a “new” trade agenda (around investment, stronger intellectual property rights, and services), which are contentious issues for most developing countries. Most developing countries insist that nothing new should be added to the negotiating agenda until the Doha Agenda (in some form) is agreed. The impasse has yet to be resolved. Yet there are quite a few issues on which governments could advance if they were to focus on confidence-building, and ensuring that they can protect their food security interests while working within a multilateral trading system.
Si-Co and Si-Zr alloys/C-material interfaces: Wetting versus Infiltration
Creators: name: Giuranno Donatella
name: Novakovic Rada
name: Sobczak Natalia
name: Nowak Rafal
name: Bruzda Grzegorz
name: Javier, Narciso
Publisher: name: Zenodo
Year: 2018

description: ORAL PRESENTATION In the manufacture of competitive composite materials through reactive infiltration, a great controversy related on the controlling stage of the infiltration process still exists. This controversy is based on the real driven force controlling the infiltration, is it a governed by Darcy's law or by the chemical reaction? To clarify this open issue, a key contribution could be coming from
 know-how on wetting characteristics, reactivity, surface properties and thermodynamics concerning the reacting phases. The works carried out jointly between N. Eustathopoulos and J. Narciso on different infiltrating systems, i.e. Ni-Si and Al-Si, in C-porous
 based materials, confirmed that reactivity at the interfaces, is the real governing phenomenon.
 To further support this conclusion, systematic investigations of wetting characteristics, reactivity, surface properties and thermodynamics concerning Si-Me/C-based substrate couples (Me = Co, Zr) have been carried out and the more relevant results obtained are reported and in this short paper.
 The outcomes here presented are doubly profitable: to study reactive infiltration process per se and to make progress in materials design of SiC-based composites. The results are collected in the framework of “SIC-WIN: Reactivity of SI-alloy/C-material system: Wetting vs Infiltration" Project, H2020-MCSA, POLONEZ-3 and some of them are here presented.
description: The NCN-National Science Center, Poland is greatly acknowledged for the financial support through the POLONEZ project number UMO-2016/23/P/ST8/01916. This project was carried out under POLONEZ-3 program which has received funding from European Union's Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement. No 665778.
Second-Life Stromspeicher - Gebäudeintegration von gebrauchten Batterien
Creators: name: Menn, Claudio
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2016
Subjects: subject: Second-Life Stromspeicher
subject: 330 - Wirtschaft
subject: 620 - Ingenieurwissenschaften und Maschinenbau

description: Elektromobilität gewinnt seit einigen Jahren an Bedeutung und Elektrofahrzeuge werden immer zahlreicher. In Anbetracht der fortschreitenden Verteuerung von CO2-Emissionen und des steigenden Umweltbewusstseins in der Bevölkerung kann auch in Zukunft mit einem wachsenden Bestand an Elektrofahrzeugen gerechnet werden. In der Schweiz fallen bereits heute jährlich mehrere Tonnen an ausser Verkehr gesetzten Batterien von Elektrofahrrädern, -autos und -scootern an. Das in erster Linie aus Lithium-Ionen (Li-Ion) Akkumulatoren bestehende Material wird derzeit lediglich energetisch verwertet, da eine Rückgewinnung von Sekundärrohstoffen wirtschaftlich uninteressant ist. Die durch diese Batterien entstehende spezifische Umweltbelastung kann mit einer verlängerten Nutzungsdauer reduziert werden. Second-Life-Speicher stellen eine Möglichkeit dar, die Nutzungsdauer zu verlängern. Dazu werden gebrauchte Batterien zu einem Elektrizitätsspeicher zusammengeführt und in Gebäuden mit Photovoltaik-Anlagen integriert. Im Rahmen des Projektes werden die offenen technischen und ökonomischen Fragestellungen zur Realisierung von Second-Life-Speichern angegangen. Zudem wird die Auswirkung einer Stromspeicherung auf die Ökobilanz von Gebäuden untersucht. Im Bereich der Produktentwicklung werden technische Anforderungen für eine sichere Integration von 2nd-Life-Speicher in Gebäuden definiert. Zu diesem Zweck wird ferner Pilotanlagen entwickelt, die im Rahmen eines bestehenden Gebäude-Monitoring-Projektes der Fachhochschule Nordwestschweiz (FHNW) zum Einsatz kommen.
Additional file 3 of Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Creators: name: Ruan, Peifeng
name: Todd, Jamie L
name: Zhao, Hongyu
name: Liu, Yi
name: Vinisko, Richard
name: Soellner, Julia F.
name: Schmid, Ramona
name: Kaner, Robert J.
name: Luckhardt, Tracy R.
name: Neely, Megan L.
name: Noth, Imre
name: Porteous, Mary
name: Raj, Rishi
name: Safdar, Zeenat
name: Strek, Mary E
name: Hesslinger, Christian
name: Palmer, Scott M.
name: Leonard, Thomas B.
name: Salisbury, Margaret L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 3: Section S2. Process used to develop classifier for molecular subtypes. Figure S1. Methods for development of classifier for molecular subtypes.
Agricultural Trade and Food Security: Some Thoughts About A Continuous Debate
Creators: name: Diaz-Bonilla, Eugenio
name: Diaz-Bonilla, Eugenio
Publisher: name: Unknown
Year: 2013
Subjects: International Relations/Trade
Food Security and Poverty

description: Current WTO trade negotiations are being held at a time of higher prices for agricultural products (compared to the 1980s and the 1990s), stronger links between energy and agriculture (with some food and feed crops being diverted for the production of biofuels), and disruptive climate change (with more frequent extreme events, such as droughts and floods). Previous agricultural trade negotiations were conducted when global prices were lower. They focused on policies that artificially expanded supply in some countries, or reduced demand in other countries through protection. Now there seems to be more interest in policies that may artificially restrict supply to other countries or expand demand in some countries. Producers were the focus of previous trade concerns; now consumer concerns seem to have come to the fore. But policy instruments and approaches to the negotiations do not seem to have changed much. There are, just as when prices were lower, again strong suggestions for higher levels of protection and inefficient and inequitable subsidies as a way to combat high prices. Several trade measures contributed to the price spike in recent years and therefore there have been discussions about the need to consider tightening current trade disciplines, particularly on the export side. Although some of the proposals are sound, if another spike occurs, the protracted WTO process may not be enough to restrain governments of exporting countries that need to react to complaints from their citizens about the price of food. When such emergencies arise, multilateral interventions based on financial aid or physical stocks would prove useful. In terms of food policies, the old dilemma between supporting high prices to help with availability of food, and pushing for lower prices to contribute to access from poor consumers continues to be present. The only way out that dilemma is based on policies that improve profits for producers through greater productivity and efficiency while expanding supply at affordable prices for consumers. In that regard, it must be remembered that adequate trade policies and WTO disciplines can contribute to food security, but they are just a component of what must be a multidimensional approach.
Methods, Materials, Procedures, Scales (Before registration)
Creators: name: Loevenbruck, Hélène
name: Chauvin, Alan
name: Huson, Nicole
name: Téo Pesci
name: Vanbuckhave, Claire
Publisher: name: OSF Registries
Year: 2021

description: You will find here the details of our method (design, material, and procedure) and the questionnaire we used to split our two groups. You will also find the screen recordings and the stimuli of our two tasks.
Agriculture and Food Security: New Challenges and Options for International Policy
Creators: name: ICTSD
name: ICTSD
Publisher: name: Unknown
Year: 2016
Subjects: Agricultural and Food Policy
Food Security and Poverty

description: New challenges are facing the global food and agriculture trading system in the 21st century. The present paper identifies options for how policies and international trade rules can respond to this new reality. It is not specifically addressed towards the ongoing negotiations of the Doha Round at the WTO, nor is there any attempt to re-define the mandate for these negotiations. The new challenges include a change in the supply-demand balance in global food and agriculture markets; large-scale use of agricultural commodities as feedstock for biofuel production; heightened market volatility; the impacts of climate change and government response; and important changes in agricultural policy regimes in major producer countries. Against this background, the paper recommends trade policy options in two areas: adapting the WTO Agreement on Agriculture and the Agreement on the Application of Sanitary and Phytosanitary Measures; and more general WTO rules of particular importance for food and agriculture, especially with regard to environmental measures. It also puts forward options targeted at international cooperation to improve food security and foster agricultural productivity. The changing conditions on agricultural markets over the past decade have brought to the fore the need to improve food security globally. Focusing on this priority can demonstrate what international trade, and the regime governing it, can do for developing countries. At the same time, work must continue towards strengthening competitive markets, removing trade barriers and minimizing policyinduced distortions while providing urgently needed public goods. Policy options that seek to act on these priorities are presented over an indicative short to long-term time horizon.
title: Erste Ergebnisse der sequentiellen Instillationstherapie mittels Bacillus-Calmette-Guerin (BCG) und elektromotiv gestützter Mitomycin-Applikation (EMDA) beim nicht-muskelinvasiven High-risk-Urothelkarzinom der Harnblase
Creators: name: Haltmair, G.
name: Sokolakis, I.
name: Scheuering, S.
name: Heller, V.
name: Bretschneider, T.
name: Nützel, R.
name: Hatzichristodoulou, G.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Das Therapieschema mit sequentieller Instillationstherapie BCG und EMDA-Mitomycin versucht die immunologische Wirkung der BCG und die chemotherapeutische Wirkung der Mitomycin zu kombinieren. Dadurch könnten die Rezidiv- und Progressionsfreiheit bei Patienten mit High-risk nicht-muskelinvasiven[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Post-print: Psychological factors associated with painful versus non-painful HIV-associated sensory neuropathy. DOI: 10.1007/s10461-017-1856-9
Creators: name: Prinisha Pillay
name: Wadley, Antonia
name: Cherry, Catherine
name: Karstaedt, Alan
name: Kamerman, Peter
Publisher: name: figshare
Year: 2017
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience and Physiological Psychology
subject: Behavioral Neuroscience

description: Post-print copy of: Pillay P, Wadley AL, Cherry CL, Karstaedt AS, Kamerman PR. Psychological factors associated with painful versus non-painful HIV-associated sensory neuropathy. AIDS and Behavior (in press). DOI: 10.1007/s10461-017-1856-9, PMID: 28710709
Data and analysis scripts: 10.6084/m9.figshare.4555474.v2
Abstract: HIV-associated sensory neuropathy (HIV-SN) is a common, and frequently painful complication of HIV, but factors that determine the presence of pain are unresolved. We investigated: (i) if psychological factors associated with painful (n = 125) versus non-painful HIV-SN (n = 72), and (ii) if pain and psychological factors affected quality of life (QoL). We assessed anxiety and depression using the Hopkins Symptoms Checklist-25. Pain catastrophizing and QoL were assessed using the Pain Catastrophizing Scale and Euroqol-5D, respectively. Presence of neuropathy was detected using the Brief Neuropathy Screening Tool, and pain was characterised using the Wisconsin Brief Pain Questionnaire. Overall, there was a high burden of pain, depression and anxiety in the cohort. None of the psychological variables associated with having painful HIV-SN. Greater depressive symptoms and presence of pain were independently associated with lower QoL. In those participants with painful HIV-SN, greater depressive symptom scores were associated with increased pain intensity. In conclusion, in a cohort with high background levels of psychological dysfunction, psychological factors do not predict the presence of pain, but both depression and presence of pain are associated with poor quality of life.