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Mifepristone and(+966505195917) Misoprostol Regimen The most common medication abortion regimen in the United States involves the use of two different medications(+966505195917): mifepristone and misoprostol. Mifepristone, also known as the abortion pill,(+966505195917) or RU-486 is sold under the brand name Mifeprex and through a generic manufactured by GenBioPro in the United States. (+966505195917)Mifepristone works by blocking progesterone, a hormone essential to the development of a pregnancy, and thereby preventing an existing pregnancy from progressing. (+966505195917)Misoprostol, taken 24–48 hours after mifepristone, works to empty the uterus by causing cramping and bleeding, (+966505195917)similar to an early miscarriage. A follow-up visit can be scheduled a week or two later, to confirm that the pregnancy was terminated via ultrasound or blood test. (+966505195917)The FDA has found that medication abortion is a safe and highly effective method of pregnancy termination. (+966505195917)When taken, medication abortion successfully terminates the pregnancy 99.6% of the time, with a 0.4% risk of major complications, and an associated mortality rate of less than 0.001 percent (0.00064%).(+966505195917)

 

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Misoprostol-Only Regimen (+966505195917)While the combined regimen of mifepristone and misoprostol for medication abortion is recommended, there is a second medication abortion protocol using misoprostol–(+966505195917)only that is more commonly used internationally and currently not approved by the FDA. (+966505195917)The regimen is also recommended for up to 70 days (10 weeks) of pregnancy. It involves taking 800 µg (4 pills) of misoprostol sublingually or vaginally every three hours for a total of 12 pills. (+966505195917)Research has shown the misoprostol-only regimen to be a safe and highly effective method of pregnancy termination, (+966505195917)however it may result in a higher incidence of side effects, particularly diarrhea, fever and chills. When taken, the misoprostol-only regimen successfully terminates the pregnancy approximately 80-100% of the time, (+966505195917)with a complication rate of less than 1%. Some U.S. (+966505195917)telehealth organizations have been providing the misoprostol-only regimen as an option for medication abortion for a number of years.(+966505195917)