title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð´Ð»Ñ ÑÐ°ÑÐ³ÐµÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð°ÑÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð´ÐµÑÐ¼Ð°ÑÐ¸ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of a complex probiotic drug for targeted therapy of atopic dermatitis
Creators: name: ÐÐ°Ð²ÑÐ´ÐµÐ½ÐºÐ¾, ÐÐ½Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÐºÑÐ»ÑÑÑÑÑ
Ð°ÑÑÐ¾Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸Ðº
Lactobacillus
ÑÐ¾ÑÐ±ÐµÐ½Ñ
probiotic cultures
autoprobiotic
sorbent

description: ÐÑÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð´ÐµÑÐ¼Ð°ÑÐ¸Ñ (ÐÑÐ) â ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÑÐ½Ð½Ð¾Ðµ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ðµ ÐºÐ¾Ð¶Ð¸, Ð½Ð°ÑÑÑÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð¶Ð½Ð¾Ð³Ð¾ Ð±Ð°ÑÑÐµÑÐ° Ð¸ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð½Ð¾Ð¹ ÐºÐ¾Ð»Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸ÐµÐ¹ Ð·Ð¾Ð»Ð¾ÑÐ¸ÑÑÐ¾Ð³Ð¾ ÑÑÐ°ÑÐ¸Ð»Ð¾ÐºÐ¾ÐºÐºÐ°, ÑÑÑÐµÐ¿ÑÐ¾ÐºÐ¾ÐºÐºÐ° Ð¸ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¸Ñ Ð³ÑÐ¸Ð±Ð¾Ð² Ð½Ð° Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ ÐºÐ¾Ð¶Ð¸. Ð£ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÐºÐ¾Ð¶Ð½ÑÐ¼ Ð´ÐµÑÐ¼Ð°ÑÐ¸ÑÐ¾Ð¼ Ð¸Ð¼ÐµÐµÑÑÑ Ð´Ð¸ÑÐ±Ð¸Ð¾Ð· ÐºÐ¾Ð¶Ð½ÑÑ Ð¿Ð¾ÐºÑÐ¾Ð²Ð¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐ½Ð¾-ÐºÐ¸ÑÐµÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°ÐºÑÐ° (ÐÐÐ¢). ÐÑÐ½Ð¾Ð²Ð½Ð°Ñ Ð·Ð°Ð´Ð°ÑÐ° Ð»ÐµÑÐµÐ½Ð¸Ñ ÐÑÐ â Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ðµ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾ÑÑ. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¿ÑÐ¾Ð²ÐµÐ´ÑÐ½Ð½Ð¾Ð³Ð¾ Ð°Ð½ÐºÐµÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ²Ð»ÑÐµÑÑÑ Ñ Ð´ÐµÑÐµÐ¹ Ð² Ð²Ð¾Ð·ÑÐ°ÑÑÐµ 1 Ð³Ð¾Ð´Ð°. Ð£ 40% Ð°ÑÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð´ÐµÑÐ¼Ð°ÑÐ¸Ñ Ð¿ÑÐ¾ÑÐ¾Ð´Ð¸Ñ Ðº ÑÐ¾Ð²ÐµÑÑÐµÐ½Ð½Ð¾Ð»ÐµÑÐ¸Ñ. ÐÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ¾ÑÑÐ°Ð²Ð° Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾ÑÑ Ð½Ð° Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¿Ð¾ÑÐ°Ð¶ÐµÐ½Ð½ÑÑ ÑÑÐ°ÑÑÐºÐ¾Ð² ÐºÐ¾Ð¶Ð¸ Ð»Ð¸Ñ Ð² ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ð¸ ÑÐµÐ¼Ð¸ÑÑÐ¸Ð¸ Ð±ÑÐ»Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Micrococcus spp. Ñ 42,8% Ð¸ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¸Ðµ Ð³ÑÐ¸Ð±Ñ Ñ 14,2%. ÐÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð² Ñ ÐºÐ¾Ð¶Ð¸ Ð¿ÑÐ¸ Ð¾Ð±Ð¾ÑÑÑÐµÐ½Ð¸Ð¸ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Staphylococcus aureus 71,4% Ð¾Ð±ÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð½ÑÑ. ÐÐ¾ÑÐºÐ¾Ð»ÑÐºÑ ÐÑÐ ÑÐ²ÑÐ·Ð°Ð½ ÑÐ¾ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸ÐµÐ¼ Ð²ÑÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÑ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ð² ÐºÐ¾Ð¶Ðµ, ÑÑÐ¾ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº Ð½ÐµÐ¾Ð±ÑÑÐ½Ð¾Ð¼Ñ ÑÐ¾ÑÑÐ°Ð²Ñ ÐºÐ¾Ð¶Ð½Ð¾Ð¹ Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾ÑÑ, ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÑÑÐµÐ¹ÑÑ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸ÐµÐ¼ ÑÐ°Ð·Ð½Ð¾Ð¾Ð±ÑÐ°Ð·Ð¸Ñ Ð¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½Ð¾Ð¹ ÐºÐ¾Ð»Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸ÐµÐ¹ Staphylococcus spp. ÐÑÐ¸Ð¼ÐµÑÐ½Ð¾ Ð¾Ñ 80 Ð´Ð¾ 90% Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÐÑÐ ÑÐ²Ð»ÑÑÑÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ¼Ð¸ Staphylococcus spp. ÐÐ½Ð¸ Ð¿Ð¾Ð´Ð²ÐµÑÐ¶ÐµÐ½Ñ ÑÐ¸ÑÐºÑ ÑÑÐ¿ÐµÑÐ¸Ð½ÑÐµÐºÑÐ¸Ð¸ ÐºÐ¾Ð¶Ð½ÑÑ Ð¿Ð¾ÑÐ°Ð¶ÐµÐ½Ð¸Ð¹ Ð¸ ÐºÐ¾Ð»Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Staphylococcus spp. ÐÐ¾ÑÐ»Ðµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¸Ñ ÑÑÐ´Ð° ÑÐ¾ÑÐ±ÐµÐ½ÑÐ¾Ð² Ð±ÑÐ»Ð¾ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾ 2 Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° â Ð¦ÐµÐ¾Ð»Ð¸Ñ Ð¸ ÐÐ¾ÑÑÐµÑÐ¸Ð½ ÑÐ»ÑÑÑÐ°, Ð»ÑÑÑÐµ Ð¿ÑÐ¾ÑÐ²Ð¸Ð²ÑÐ¸Ðµ Ð°Ð½ÑÐ°Ð³Ð¾Ð½Ð¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð»Ð°ÐºÑÐ¾Ð±Ð°ÐºÑÐµÑÐ¸Ð¹. ÐÐ° Ð¸Ñ Ð¾ÑÐ½Ð¾Ð²Ðµ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°.
description: Atopic dermatitis (AtD) is a common inflammatory skin disease, a violation of the skin barrier and increased colonization of Staphylococcus aureus, Streptococcus and microscopic fungi on the skin surface. Patients with dermatitis have dysbiosis of the skin, as well as the gastrointestinal tract (gastrointestinal tract). The main task of AtD treatment is to restore the normal structure of the microbiota. According to the results of the survey, the disease manifests itself in children aged 1 year. 40% of atopic dermatitis passes by adulthood. When studying the composition of the microbiota on the surface of the affected areas of the skin of persons in remission, Micrococcus spp. was detected in 42.8% and microscopic fungi in 14.2%. When examining skin samples with exacerbation of the disease, Staphylococcus ssp. was detected in 71.4% of the examined. Since AtD is associated with a decrease in the production of antimicrobial peptides in the skin, this leads to an unusual composition of the skin microbiota, characterized by a decrease in diversity and increased colonization of Staphylococcus ssp. Approximately 80 to 90% of patients with AtD are carriers of Staphylococcus ssp. They are at risk of superinfection of skin lesions and colonization by Staphylococcus ssp. After reviewing a number of sorbents, 2 drugs were identified â Ceolit and Zosterin ultra, which showed better antagonistic properties of lactobacilli. On their basis, it is possible to create a drug.