cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells
Creators: name: Jiang, Chang
name: Zhijie Ding
name: Joy, Marion
name: Souvik Chakraborty
name: Kim, Su Hyeong
name: Bottcher, Ralph
name: Condeelis, John
name: Shivendra Singh
name: Partha Roy
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Profilin-1 (Pfn1) is an important actin-regulatory protein that is downregulated in human breast cancer and when forcibly elevated, it suppresses the tumor-initiating ability of triple-negative breast cancer cells. In this study, we demonstrate that Pfn1 overexpression reduces the stem-like phenotype (a key biologic feature associated with higher tumor-initiating potential) of MDA-MB-231 (MDA-231) triple-negative breast cancer cells. Interestingly, the stem-like trait of MDA-231 cells is also attenuated upon depletion of Pfn1. A comparison of cancer stem cell gene (CSC) gene expression signatures between depleted and elevated conditions of Pfn1 further suggest that Pfn1 may be somehow involved in regulating the expression of a few CSC-related genes including MUC1, STAT3, FZD7, and ITGB1. Consistent with the reduced stem-like phenotype associated with loss-of-function of Pfn1, xenograft studies showed lower tumor-initiating frequency of Pfn1-depleted MDA-231 cells compared to their control counterparts. In MMTV:PyMT mouse model, homozygous but not heterozygous deletion of Pfn1 gene leads to severe genetic mosaicism and positive selection of Pfn1-proficient tumor cells further supporting the contention that a complete lack of Pfn1 is likely not conducive for efficient tumor initiation capability of breast cancer cells. In summary, these findings suggest that the maintenance of optimal stemness and tumor-initiating ability of breast cancer cells requires a balanced expression of Pfn1.
Dynamics of CD4 cell count among HIV-infected individuals in Lagos, Nigeria
Creators: name: Babatunde O. Motayo
name: Babatunde A. Olusola
name: Adedayo O. Faneye
name: Aturaka, Solomon
name: Olukunle Oluwasemowo
name: Ogiogwa, Joseph I
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Human immunodeficiency virus (HIV) infection leads to progressive loss of CD4 T cells. Antiretroviral therapy has been able to inhibit this process, resulting in significant level of immune recovery and function. Our aim is to investigate the dynamics of CD4 recovery among HIV patients in Lagos, Nigeria. A total of 213 HIV-positive individuals were enrolled between October 2007 and May 2008, and followed up for 9 months based on CD4 count. CD4 analysis was done by flow cytometry at enrollment and after every 3 months. Data were grouped according to age range, antiretroviral treatment (ART), and time between infection and diagnosis. Kaplan–Meier survival analysis was used for data analysis. There was a significant difference in CD4 count between antiretroviral (ART) naïve and ART experienced subjects (P
Additional file 1 of Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis
Creators: name: Chu, Min
name: Fan, Yingchao
name: Wu, Liting
name: Ma, Xiaoyan
name: Sao, Jinfeng
name: Yao, Yonghua
name: Zhuang, Wenfang
name: Zhang, Cui
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 1: Supplementary Table 1. Difference in BDNF-AS expression in multiple myeloma patients grouped by clinicopathological characteristics.
Sustainable Food Cities: The essential role of food for sustainability
Creators: name: Edwards, Ferne
Publisher: name: Zenodo
Year: 2019

description: The theme of this European Roundtable on Sustainable Consumption and Production (ERSCP) was the transition to a circular Europe by transforming production and consumption to make it more sustainable. The European Commission defined the EU Action Plan for Circular Economy: Closing the Loop, which aims at being instrumental in reaching the Sustainable Development Goals (SDGs) by 2030, in particular Goal 12 of ensuring sustainable consumption and production patterns. I spoke about the role of food in cities in the plenary session, ‘Building synergies across the SDGs: Food, Waste and Sustainable Cities’.
تناسخ از منظر فرق اسماعیلی
Creators: name: Zare'ee, Maryam
name: Shahangian, Noori sadat
Publisher: name: Zenodo
Year: 2015
Subjects: تناسخ
فرق
اسماعیلیه
معاد روحانی

description: Transmigration means the departure of the soul from the body and it again referring and belonging to other bodies, including former body or a new body, fundamental doctrine about the fate of the soul and the afterlife in Hindi and Buddhist religions. Belief in the idea attributed to some Shiah sects; including the Ismailis, as one of the largest Shiah sects have been accused of accepting transmigration. Ismailia emphasis on spiritual resurrection and also the philosophical method adopted of the Neo-Platonists about soul, it has strengthened the possibility that they may have accepted transmigration. Hence, it is necessary to examine the claim that the idea of transmigration in Ismailia will be reflected, reviewed and rereading. This problem has several dimensions and the purpose of the present paper is to examine this doctrine. The present study makes it clear that the belief in resurrection and transmigration in a branching of the Ismailia sect, in terms of foundations, pillars and goals are different.
description: يكي از مسائلي كه عموما در اديان مختلف مورد توجه قرار گرفته چيستي و سرنوشت روح پس از مرگ است.پيوسته اختلاف نظرهايي در رابطه با نحوه بقاي روح وجود داشته است.در اين ميان برخي از اديان،تناسخ را به عنوان راه حل مطرح كرده اند.باور به اين انديشه به بعضي از فرق شيعي نيز نسبت داده شده است؛از جمله اسماعيليه به پذيرش تناسخ متهم شده اند.برهمين اساس،دست يابي به مواضع فرقه ها ي اسماعيلي درباره تناسخ با مراجعه به آثار اصلي و مهم اسماعيليان هدف مقاله پيش روي ماست.تحقيق حاضر روشن مي سازد كه فرق اسماعيلي در پذيرش وجوه تناسخ با يكديگر داراي تفاوت مي باشند.
Synthesis and antiviral activity of novel a-aminophosphonates containing 6-fluorobenzothiazole moiety
Creators: name: Dandan Xie
name: Awei Zhang
name: Dengyue Liu
name: Limin Yin
name: Jingbo Wan
name: Zeng, Song
name: Deyu Hu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: A series of novel a-aminophosphonates containing 6-fluorobenzothiazole moiety derivatives were synthesized by one-pot reaction under microwave irradiation and their structures were characterized by IR, 1H, 13C, and 31P NMR and element analysis data. Antiviral assays showed that some compounds possess good curative and protective activities against tobacco mosaic virus (TMV) in vivo at 500 µg/mL In particular, compounds diethyl [(6-fluorobenzo[d]thiazol-2-ylamino)(phenyl)methyl]phosphonate (4b), diethyl [(6-methoxybenzo[d]thiazol-2-ylamino)(thiophen-2-yl)methyl]phosphonate (4j) and diphenyl [(6-fluorobenzo[d]thiazol-2-ylamino)(4-methoxyphenyl)methyl]phosphonate (4q) exhibited remarkable antiviral activities than Ribavirin against TMV and PVY. Compound diphenyl [(6-fluorobenzo[d]thiazol-2-ylamino)(4-methoxyphenyl)methyl]phosphonate (4q) showed similar curative and protective activity against potato virus Y (PVY) to Dufulin.
Design, synthesis and cytotoxic activity of vitamin E bearing selenium compounds against human breast cancer cell line (MCF-7)
Creators: name: Shams H. Abdel-Hafez
name: Abdelwahab, Ahmed B.
name: Kirsch, Gilbert
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: A new series of vitamin E/selenated pyridine, vitamin E/selenated pyridazine, vitamin E/selenated coumarine and vitamin E/selenated nicotine moieties were synthesized and their cytotoxic activity is investigated using the human breast cancer cell line. The newly synthesized compounds were characterized using spectroscopic tools (IR, 1H NMR, 13C NMR, and mass spectroscopy) as well as microanalysis. Our study reveals that compound vitamin E/selenated nicotine moiety has the highest cytotoxic effect than the other synthesized compounds.
DYNAMICS OF CD4 CELL COUNT AMONG HIV INFECTED INDIVIDUALS IN LAGOS, NIGERIA
Creators: name: Babatunde O Motayo
name: Babatunde A Olusola
name: Adedayo O Faneye
name: Aturaka, Solomon
name: Olukunle Oluwasemowo
name: Ogiogwa, Joseph I
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Human Immunodeficiency virus (HIV) infection leads to progressive loss of CD4 T- cells. Antiretroviral therapy has been able to inhibit this process, resulting in significant level of immune recovery and function. Our aim is to investigate the dynamics of CD4 recovery among HIV patients in Lagos, Nigeria. 213 HIV positive individuals were enrolled between October 2007 and May 2008, and followed up for 9 months based on CD4 count, CD4 analysis was done by flow cytometry at enrolment and after every 3 months. Data was grouped according to age range, antiretroviral treatment (ART), and time between infection and diagnosis. Kaplan Meier Survival analysis was used for data analysis. There was a significant difference in CD4 count between antiretroviral (ART) naïve and ART experienced subjects (P < 0.001). About 50% of the ART experienced population was identified to show poor CD4 reconstitution unable to achieve a CD4 of 500 cells/µl after 9 months of therapy. Time interval between infection and therapy was also identified to contribute to poor CD4 restoration. Further studies need be done to classify immunological non responders among HIV patients in Nigeria. We also recommend introduction of programs that will facilitate early detection of HIV infection.
Temporal variation and co-occurrence patterns of bacterial communities in eutrophic Lake Taihu, China
Creators: name: Yuke Peng
name: Dongmei Yue
name: Xiao, Lin
name: Qian, Xin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: To understand the long-term and local variations of bacteria under the influence of annually re-occurred water bloom, bacterial community composition (BCC) was investigated monthly for 3 years (2009–2011) at 4 different sites located across Lake Taihu. The bacterial community composition was analyzed by 16S rRNA gene clone libraries and terminal restriction fragment length polymorphism (T-RFLP). Co-occurrence patterns among bacterial taxa and environmental variables were determined through network analysis. Overall, strong seasonal variation patterns of BCC were observed whilst the spatial variations of BCC were slight in the long-term observation. However, core species bacteria persisted throughout the annual variations. Network analysis showed that the highly connected OTUs in bacteria-environment network included both of the numerically dominant taxa and some of functional groups with low abundance such as Methylophilaceae and Nitrospira. Co-occurrence networks further revealed that the correlations of bacteria-bacteria could be more critical than those between environment and bacteria in structuring microbial communities, and would be a crucial driving factor of BCC in Lake Taihu.
Additional file 1 of CRISPR guides induce gene silencing in plants in the absence of Cas
Creators: name: Sharma, Veerendra Kumar
name: Marla, Sandeep
name: Zheng, Wenguang
name: Mishra, Divya
name: Huang, Jun
name: Zhang, Wei
name: Morris, Geoffrey Preston
name: Cook, David Edward
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig S1. Cas13a mediates efficient virus interference. Fig S2. crRNA inhibits TuMV accumulation with and without the Cas13 protein. Fig S3. GIGS can function systemically to achieve virus interference. Fig S4. Guide crRNA design and target sites for endogenous mRNA reduction by GIGS. Fig S5. Endogenous mRNA reduction mediated by Cas13-dependent and GIGS expression. Fig S6. Guide targets and experimental design for systemic endogenous mRNA reduction by GIGS. Fig S7. Systemic endogenous mRNA reduction by GIGS. Fig S8. Cas13-dependent and GIGS T1 transformed A. thaliana lines display phenotypes consistent with TTG1 reduction. Fig S9. Expression and translation products for Cas13 targeting TTG1 transgenic Arabidopsis. Fig S10. Small RNA mapping to the expressed crRNA and hairpin constructs targeting the PDS transcript from spot infiltration experiments. Fig S11. Small RNA mapping to the expressed crRNA and hairpin constructs targeting the PDS transcript from TRV expression experiments. Fig S12. Guide crRNA with mismatches at base pairs 10,11 do not elicit GIGS. Fig S13. Cas9 sgRNA can elicit GIGS photobleaching in N. benthamiana. Fig S14. Cas9 sgRNA induced GIGS is dependent on at least 28 nt targeting sequence in N. benthamiana.
New zinc(II), copper(II), nickel(II), and vanadium(IV) complexes containing disulfide ligand: Synthesis, spectroscopic studies and calf thymus DNA interaction investigation
Creators: name: Shafaatian, Bita
name: Atefeh Baharian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: New Schiff base complexes of zinc(II), copper(II), nickel(II), and vanadium(IV) were synthesized using the Schiff base ligand formed by the condensation of 2-aminoethanethiol and 2-hydroxy-1-naphthaldehyde. The tetradentate Schiff base ligand N,N´-(3,4-dithiahexane-1,6-diyl)bis(2-hydroxy-1-naphthaleneimine), containing a disulfide bond, was coordinated to the metal(II) ions through the two azomethine nitrogen atoms and two deprotonated phenolic oxygens of two different ligands which was connected to each other by sulfur-sulfur bond. The molar conductivity values of complexes in DMSO solvent implied the presence of nonelectrolyte species. The fluorescence properties of the Schiff base ligand and its complexes were studied in dimethylsulfoxide. The Schiff base ligand and its complexes were characterized by FT-IR, 1H NMR, UV/Vis spectroscopies, elemental analysis, and conductometry. The crystal structure of tetradentate Schiff base ligand was characterized by single crystal X-ray diffraction. The Schiff base ligand was contained disulfide bond. Furthermore, the binding interaction of these complexes with calf thymus DNA (CT-DNA) was investigated by different methods.
Microwave-assisted synthesis and anti-inflammatory activity evaluation of some novel α-aminophosphonates
Creators: name: B. Sujatha
name: S. Mohan
name: Ch. Subramanyam
name: K. Prasada Rao
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: An expeditious green synthetic approach was developed for the synthesis of α-aminophosphonates in good yields through one-pot three component reaction (Kabachnik-Fields reaction) of equimolar quantities of N-(4-amino-2-phenoxy phenyl)methanesulfonamide, diethylphosphite and various aldehydes under conventional as well as microwave irradiation methods. The newly synthesized compounds were characterized by NMR (31P, 1H, and 13C), Mass, IR and C, H, N analyses. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed good anti-inflammatory activity when compared with standard drug. Especially the compounds 5d bearing 4-hydroxy-3-nitrophenyl moiety, 5e bearing 3-bromo-4-fluorophenyl moiety, 5g incorporated with 2,4-dichlorophenyl moiety and 5f containing 4-chlorophenyl moiety exhibiting edema inhibition of 91.01% to 85.39% after 4 h of carrageenan injection while the other compounds displayed inhibition ≥75%.
BRIDGING THE FINANCIAL GAP: FOSTERING SUSTAINABLE GROWTH IN PALESTINIAN SMES THROUGH P2P LENDING FINTECH AND BUSINESS SUPPORT SERVICES
Creators: name: RABAH Y. R. ABDALJAWAD
name: W MUHAMMAD ZAINUDDIN B WANABDULLAH
name: NURASYIKIN BINTI JAMALUDIN
Publisher: name: Zenodo
Year: 2024
Subjects: P2P Lending Fintech, Business Support Services, Access to Finance, SMEs Sustainable Growth.

description: Abstract

Small and medium-sized enterprises (SMEs) serve as vital pillars of the Palestinian economy by creating job opportunities and driving innovation. However, their sustainable growth and performance are impeded by limited access to credit, especially external funding, which ultimately caused it to withdraw from the market and the competition. This study explores the potential of peer-to-peer (P2P) lending Fintech and business support services to bridge the financial gap and foster sustainable growth in Palestinian SMEs while highlighting the mediating role of financial access in these relationships. The deductive approach was used, focusing on quantitative research, primary data was collected using a non-probability sampling strategy known as convenience sampling, using a developed questionnaire, and statistical analysis was done using PLS-SEM. The study targeted a community of 4374 diverse Palestinian small and medium enterprises. Potential respondents include owners, CEOs, and CFOs. Therefore. The final valid number was a convenient sample of 363 small and medium-sized enterprises. The findings demonstrated a significant mediation effect of access to finance on the relationship between P2P lending, Business support services, and sustainable growth. Furthermore, the study recommended the necessity of adopting BSS and P2P systems by decision-makers in Palestine, where the study provided valuable insights into the impact of P2P lending Fintech lending and business support services on Palestinian SMEs’ financial access and sustainable growth.
MOESM3 of Comprehensive genomic analysis of the DUF4228 gene family in land plants and expression profiling of ATDUF4228 under abiotic stresses
Creators: name: Yang, Qi
name: Niu, Xiaocui
name: Tian, Xiaona
name: Zhang, Xiujuan
name: Cong, Jingyu
name: Wang, Ruigang
name: Zhang, Guosheng
name: Li, Guojing
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 3: Figure S1. Details of the phylogenetic classification of DUF4228 genes in land plant lineages. Phylogenetic tree was constructed using the ML method with IQ-tree. Green lines represent bryophytes, pink lines represent pteridophytes, blue lines represent gymnosperms and red lines represent angiosperms.
Immobilized molybdenum acetylacetonate complex on expanded starch for chemoselective oxidation of sulfides to sulfoxides with t-BuOOH at room temperature
Creators: name: Hong, Mei
name: Yan, Jun-Min
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry

description: We explored a highly efficient protocol for the oxidation of alkyl aryl sulfides to sulfoxides with high selectivities catalyzed by a molybdenum acetylacetonate complex immobilized on expanded corn starch (ECS-MoO2(acac)2) in the presence of 70% t-BuOOH solution (water). We obtained predominantly the monooxygenated product. The resulting products were obtained in good to excellent yields within a reasonable time. The catalyst could readily be separated from the reaction mixture and reused for several runs without significant loss in catalytic efficiency.
title: The Ballad of Hicks Carmichael: Law, Music, and Popular Justice in Urban Appalachia
Creators: name: Mercer, William Davenport
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2018
Subjects: subject: Law and the humanities
subject: law and music
subject: popular justice
subject: law and society
subject: Appalachian history
subject: urban history
subject: 340

description: This article examines a rare folk ballad to revisit an 1888 Tennessee trial that newspapers referred to as the fastest in the country in which the death penalty was involved. If we look at this event using court records and newspapers, it tells a regrettably common story of a court under pressure from the populace skirting the protections of law. However, if we consider the trial as a performative endeavor, we can rightly consider other performative events, like folk songs, not as reflective of official events but as equivalents that help provide insight into the larger motives behind the court’s actions.
description: Law, Culture and the Humanities, vol. 18, no. 1, p. 187
title: Risikofaktoren für okuläre Hypotonie nach XEN Gel Stent Implantation
Creators: name: Galimi, Maria Elena
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Hintergrund: Untersuchung der Inzidenz postoperativer okulärer Hypotonie und der Risikofaktoren für deren Entwicklung in Augen, die eine XEN Gel Stent Implantation erhalten haben. Methoden: In dieser retrospektiven, monozentrischen Fallserie wurden Patientendaten zu 170 aufeinanderfolgenden XEN Gel Stent Implantationen mit oder ohne gleichzeitiger Phakoemulsifikation und Hinterkammerlinsenimplantation bei Patienten mit primärem oder sekundärem Offenwinkelglaukom analysiert. Primäre Ergebnisparameter waren das Auftreten einer postoperativen Hypotonie und potenzielle Risikofaktoren für deren Entwicklung. Sekundäre Parameter waren die prä und postoperative Sehschärfe, der Augeninnendruck (IOD) und die Anzahl der lokal angewendeten antiglaukomatösen Wirkstoffe. Ergebnisse: Postoperative Hypotonie ≤ 6 mmHg trat bei 57% der Augen auf. Bei 70,1% der betroffenen Augen verlief die Hypotonie komplikationslos, bei 13,4% traten vorübergehende Komplikationen mit spontaner Besserung auf und bei 16,5% traten Komplikationen auf, die behandlungsbedürftig waren. Die mittlere Sehschärfe (logMAR) vor der Operation betrug 0,47 ± 0,46. In der postoperativen Kontrolle nach 4 Wochen lag die mittlere Sehschärfe bei 0,47 ± 0,48. Es gab keinen signifikanten Unterschied der best corrected visual acuity (BCVA) in der Gruppe der Augen mit und ohne postoperativer Hypotonie vor und nach der Operation. Der mittlere Augeninnendruck vor der Operation betrug 24,6 ± 8,4 mmHg und sank nach 4 Wochen deutlich auf 18,4 ± 10,2 mmHg. Augen mit einer axialen Länge über 24,3 mm hatten ein dreifach erhöhtes Risiko für eine postoperative Hypotonie (OR 3,226, 95 %-Konfidenzintervall 1,121–9,279). Dieses Risiko war bei Augen mit gleichzeitiger Kataraktoperation verringert (OR 0,483, 95 %-Konfidenzintervall 0,258–0,903). Schlussfolgerung: In unserer Analyse war die postoperative Hypotonie eine häufige Komplikation nach XEN Gel Stent Implantation. Schwerwiegende, anhaltende Komplikationen waren jedoch selten. Eine größere Achsenlänge stellt einen Risikofaktor für die Entwicklung einer okulären Hypotonie dar.
Synthesis and spectroscopic characterization of tris(tert-butoxy)siloxy titanium and hafnium complexes: Molecular precursor to [M/Si/O (M = Ti, Hf)] materials
Creators: name: Gopalakrishnan, Mohan
name: Swaminathan Shanmugan
name: Nallasamy Palanisami
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The reaction of one equivalent of metallocene dichloride Cp2MCl2 (M = Ti, Hf) with two molar equivalents of sodium salt of tri(tert-butoxy)siloxane, (tBuO)3SiONa, in toluene yields Cp2Ti[OSi(OtBu)3]2 (1) and Cp2Hf[OSi(OtBu)3]2 (2). These compounds were characterized by analytical and spectroscopic techniques (C/H/N analysis, FT-IR, NMR, EI-MS, and thermal analysis). An independent thermolysis of 1 and 2 at low temperature resulted in the formation of the corresponding metal silicates MO2·2 SiO2 [M = Ti (3) and Hf (4)] as evidenced by infrared spectroscopy, powder X-ray diffraction analysis (PXRD), and scanning electron microscopy (SEM). These thermally stable amorphous metal silicate materials (3 and 4), albeit exhibiting moderate surface areas, are found to be microporous by N2 adsorption studies. UV-vis-NIR spectroscopy shows low energy band gap Eg = 2.63 eV for 3 and 2.99 eV for 4 due to the silicon oxide mixed with the corresponding transition metal oxides. The photocatalytic activity of titanium silicate material (3) has been explored in terms of degradation of methylene blue.
Diagnosing subclinical facial eczema in cattle: does combining liver enzyme tests increase the accuracy of diagnosis?
Creators: name: Laven, RA
name: Cuttance, EL
name: Yang, DA
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: To assess whether adding glutamate dehydrogenase (GDH) activity measurements to measurements of gamma-glutamyl transferase (GGT) activity appreciably increases the accuracy of diagnosis of subclinical facial eczema (FE) in cattle. As part of a larger study on the impact of FE on productivity, GGT and GDH activities were measured in serum samples collected from 426 cattle from one dairy farm in the Taranaki region in April 2018. Bayesian latent class analysis was then used to estimate herd prevalence of subclinical FE as well as the specificity and sensitivity of the activity in serum of GGT or GDH alone, and of GGT and GDH activities combined, as diagnostic tests for subclinical FE. The latent class analysis estimated the true prevalence of subclinical FE in the study population as 47.5 (95% probability interval (PI) = 38.3–55.3)%. There was no evidence of any clinically relevant difference between GGT and GDH activities as predictors of subclinical FE; the difference between the areas under the receiver operating characteristic curves for the two measures was 0.005 (95% PI = –0.02 to –0.03). Using the two tests in parallel, with a threshold of 50 IU/L for GGT and 225 IU/L for GDH resulted in specificity and sensitivity of >95%, markedly increasing the accuracy of diagnosis of subclinical FE compared to using GGT or GDH alone at any threshold In this herd, combining the two tests resulted in a clinically relevant improvement in the accuracy of diagnosis of subclinical FE compared to using either test alone, which if used at the individual level will result in fewer cattle being assigned the wrong FE status. This will also apply at the herd level, with combined testing producing fewer false-positive herd test results than using one enzyme alone. This is particularly important for monitoring the efficacy of FE control measures when the expectation should be that the proportion of cattle with FE is very low.
Open hip reduction using a novel transarticular suture stabilisation technique in 24 dogs: a retrospective study of technique, outcome and complications
Creators: name: Hybki, G
name: Robbins, M
name: Kwan, T
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Medical records of a single private practice (Illinois, USA) were retrospectively reviewed to identify dogs (n = 24) that had an open hip reduction with a transarticular suture stabilisation technique after presenting with a traumatic coxofemoral luxation between April 2003 and December 2018. Dogs that met the inclusion criteria were of various breeds with a median body weight of 18.1 (min 4.2, max 54.5) kg and mean age at presentation of 6.5 (min 1, max 11) years. The surgical technique, short-term outcome and complications were extracted from the medical records. Long-term (>2 years) follow-up data was obtained by a telephone interview with each owner. All dogs underwent open hip reduction using a novel transarticular suture stabilisation technique. The outcome was reported by owners to be excellent in 18/24 (75%) dogs with full return of limb function. Sixty-six percent (16/24) of owners reported that no lameness was observed 2 months after surgery. No minor complications were noted in this study. The hips of 6/24 (25%) dogs reluxated after surgery (defined as a major complication), which required femoral head and neck excision surgery. Open coxofemoral joint reduction using a novel transarticular suture technique is a viable surgical option to consider in dogs that present with a traumatic coxofemoral luxation.
Animal safety of a tall fescue endophyte (Epichloë sp.) in a perennial ryegrass (Lolium perenne) host
Creators: name: Croy, RG
name: Sutherland, BL
name: Hume, DE
name: Mace, WJ
name: van Koten, C
name: Finch, SC
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: To assess animal health and production in sheep grazing perennial ryegrass (Lolium perenne) infected with a tall fescue endophyte (Epichloë sp.). Three replicates of pure perennial ryegrass pastures infected with AR501 tall fescue endophyte (AR501 HE), AR1, AR37 or standard endophyte (STD) (all >85% infection) and a low endophyte control (AR501 LE) were grazed by 10 lambs for 7 weeks during late summer/early autumn, 2017. AR501 HE and AR501 LE were in the same tetraploid cultivar and the remaining treatments were in the same diploid cultivar. Lambs were weighed on Days 0, 19, 37 and 48 and assessed for ryegrass staggers on a 0–4 tremor scale nine times from Day 13. On Days 14 and 20, rectal temperatures and respiration rates were measured in lambs grazing AR501 HE, AR501 LE and STD under heat load. Pasture samples from each treatment were taken regularly (8 times) for analysis of known endophyte secondary metabolites. Peak mean ryegrass staggers scores for lambs grazing STD and AR37 treatments were 3.9 and 2.7, respectively, indicating environmental conditions were conducive to toxicity. Lambs grazing AR501 HE showed no ryegrass staggers at any date. The liveweight of STD lambs was up to 6.6 kg less than some or all other treatments on Days 19, 34 and 48, but there was no evidence of a difference between the liveweight of AR501 HE lambs and AR501 LE, AR37 or AR1 lambs on any date. Rectal temperatures and respiration rates of STD lambs were higher than AR501 HE lambs by 0.2°C and 26 breaths/minute, respectively. Apart from lower rectal temperature of AR501 HE lambs on Day 14, there was no evidence of differences between the AR501 HE and AR501 LE lambs. N-Formylloline was the only loline present in AR501 HE herbage (350–860 mg/kg). Peramine in AR501 HE herbage (42–77 mg/kg) was greater than that in STD and AR1 herbage on five and seven of the eight sampling dates, respectively. Lambs grazing AR501 HE showed no ryegrass staggers, exacerbated heat stress or suppressed liveweight gain compared with lambs grazing AR501 LE in a season when endophyte-induced toxicity was evident in STD and AR37 pastures. This suggests AR501 tall fescue endophyte does not produce toxic concentrations of secondary metabolites. This study suggests that there are no secondary metabolites produced by the tall fescue AR501 endophyte-perennial ryegrass association which affect animal health or production.
The Essential Role of Food in Sustaining Cities
Creators: name: Edwards, Ferne
name: Gerritsen, Roos
Publisher: name: Zenodo
Year: 2019

description: ‘Why the World Needs Anthropologists’ conference (WWNA) with this year’s theme of ‘Sustaining Cities’ brings together academia and industry for sustainable impact. The conference goals are to inspire and incite action, foster fruitful collaborations and exchange ideas and practices towards participating actively in the cities that we live, build and work in, involving designers, urbanists, planners, architects and applied anthropologists. This presentation explores the vital role of food in sustaining cities.
Additional file 4 of A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys
Creators: name: Jia, Huanhuan
name: Chen, Meili
name: Cai, Yanzhen
name: Luo, Xiaoling
name: Hou, Gang
name: Li, Yongfeng
name: Cai, Chunmei
name: Chen, Jun
name: Li, Qingnan
name: Miu, Kai-Kei
name: Fung, Sin-Hang
name: Wang, Zhangting
name: Huang, Ren
name: Shen, Huiyong
name: Lu, Li
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Virology

description: Additional file 4: Supplementary Table 4. Stretches of joints (mean±sd).
Synthesis of 4-acetyl-2(3H)-benzothiazolone: Sulfur bioisostere of benzoxazolone allelochemicals
Creators: name: Gerova, Mariana S.
name: Svetoslavov, Filip E.
name: Shivachev, Boris L.
name: Rositsa P. Nikolova
name: Petrov, Ognyan I.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Plant Biology
subject: Computational Biology

description: A multi-step methodology for the synthesis of 4-acetyl-2(3H)-benzothiazolone was developed in order to prepare a new biomimetic analogue of benzoxazolone allelochemicals. The compound was prepared from commercially available o-toluidine in 23% overall yield. The structure of 4-acethyl-2(3H)-benzothiazolone was confirmed by NMR spectroscopy and X-ray crystallography.
A statistical evaluation of associations between reproductive performance and milk composition and animal factors on grazing dairy cows in two New Zealand dairy farms
Creators: name: Rodriguez-Cutzal, LX
name: Burke, JL
name: Correa-Luna, M
name: Lopez-Villalobos, N
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: To determine if milk composition, milk yield, live weight, live weight change, breed and heterosis are associated with reproductive performance in dairy cows from two dairy farms under New Zealand grazing conditions. Milk composition was determined in herd tests from 205 Holstein-Friesian (F), 77 Jersey (J) and 351 F × J crossbred cows from two Massey University dairy herds in the 2016 and 2017 production seasons. Mating occurred from October to December in each production season. The start of breeding to first service (SBFS), start of breeding to conception (SBCO), submission rate at 21 days (SR21), pregnancy rate at 21 (PR21) and 42 days (PR42) were calculated for each cow. These traits were analysed using mixed linear models that included fixed effects for herd, production season, regression coefficients of deviation from median calving date, lactation number, proportion of F, F × J heterosis, energy-corrected milk yield (ECMY), percentages of fat, protein and lactose, milk urea nitrogen (MUN), live weight and change in live weight, with random effects for cow and residual error. The variables with binomial distribution were analysed using logistic regression. Deviation from the herd’s median calving date had a significant effect (p This study confirms that breed, heterosis, ECMY, protein and lactose percentages, live weight change and calving date are associated with the reproductive performance of grazing cows. Results from this study contrast with the historical antagonism between milk production and reproductive performance in dairy cattle, demonstrating that well managed cows can achieve high levels of production and good reproductive performance. MUN was not associated with reproductive performance traits, except with SR21.
TMT-Based proteomics analysis of LPS-induced acute lung injury
Creators: name: Chen, Shengsong
name: Zhang, Yi
name: Zhan, Qingyuan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: The proteome during lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice is unclear. In this study, eight-week-old male C57BL/6 mice were intraperitoneally injected with LPS and sacrificed 18 hours after LPS administration to identify protein expression levels in lung tissue using tandem mass tag (TMT) analysis for relative quantification. Hematoxylin-eosin (HE) staining was used to evaluate lung injury in mice. Immunohistochemical staining was used to calculate the production of myeloperoxidase (MPO) and TUNEL staining was performed to detect apoptosis. GO functional clustering and KEGG pathway enrichment analyses were performed to determine functions of differentially expressed proteins (DEPs) and transduction pathways. Domain annotation and subcellular localization analysis of the DEPs were also performed. Furthermore, parallel reaction monitoring (PRM) analysis was used to verify the top 30 DEPs. A total of 5188 proteins were found to be expressed in lung tissues from LPS- and saline-treated mice. Among these proteins, 293 were differentially expressed between the two groups; 255 proteins were upregulated in the LPS-treated ALI mice, while 38 were downregulated. GO analysis showed that the DEPs are mainly extracellular, and KEGG analysis suggested that the DEPs are mainly enriched in the NOD-like receptor signaling pathway, complement and coagulation cascades and natural killer cell-mediated cytotoxicity. Enrichment of the DEPs is mainly peptidase S1A, serine proteases, peptidase S1, and the serpin domain. 26.6% of the DEPs are in the nucleus, 24.6% are in the cytosol, 19.1% are in the extracellular space, and 18.8% are in the plasma membrane. PRM validation showed that the trend of 30 DEPs was same with TMT analysis. Among these, Cytochrome b-245 heavy chain (Cybb), Monocyte differentiation antigen CD14 (Cd14) and Neutrophil gelatinase-associated lipocalin (NGAL) were the most obvious change. Our results may help to identify markers and therapeutic targets for LPS-induced ALI.
Synthesis, structural, DFT calculations and Hirshfeld surface analysis of (N-butyl-N-(4-fluorobenzyl)dithiocarbamato-S,S')-(thiocyanato-N)(triphenylphosphine)nickel(II) and preparation of nickel sulfide from nickel(II) dithiocarbamate
Creators: name: Pandurangan Selvaganapathi
name: Subbiah Thirumaran
name: Ciattini, Samuele
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Bis(N-butyl-N-(4-fluorobenzyl)dithiocarbamato-S,S')nickel(II) (1) and (N-butyl-N-(4-fluorobenzyl)dithiocarbamato-S,S')(thiocyanato-N)(triphenylphosphine)-nickel(II) (2) have been prepared. Both the complexes have been characterized by elemental analyses, IR, electronic and 1H and 13C NMR spectroscopy. Single crystal X-ray analysis of complex 2 showed a distorted square planar configuration around the nickel atom due to steric effect of the triphenylphosphine and the bidentate chelation by two sulfur atoms of the dithiocarbamate ligand. UV-Vis spectral data of 1 and 2 are consistent with the formation of square planar nickel(II) complexes. Hirshfeld surface analysis was also carried out to provide qualitative and quantitative insights into the intermolecular interactions in 2. Molecular electrostatic potential surface map reveals that the negative charge is delocalized over S atoms of NCS2 and the positive charge is localized over N atom of NCS2 group. This indicates the considerable double bond character of the C-N (thioureide) bond. Nickel sulfide nanoparticles have been prepared from complex 1 and characterized using PXRD, EDS, UV-DRS, and SEM. EDS analysis confirm the formation of nickel sulfide.
Triphenylarsine as an effective catalyst in a mechanistic investigation of trans- 1, 2-di (methoxycarbonyl)-6, 6-dimethyl-5, 7-dioxaspiro [2, 5] octane-4, 8-dione formation
Creators: name: Ghodsi, Fatemeh
name: Sayyed Mostafa Habibi-Khorassani
name: Shahraki, Mehdi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: The kinetics and mechanism of the reaction between dimethyl acetylendicarboxylate (DMAD) and Meldrum's acid (MA) in the presence of triphenylarsine (TPA) as a catalyst were investigated in a methanol environment by the UV/vis spectrophotometry technique. In this work, the reaction followed second- order kinetics and the first and second steps of the reaction mechanism were recognized as the fast and rate-determining step (RDS), respectively. A significant point in this reaction “in comparison with previous work” is related to the change in behavior of the kinetics and reaction mechanism in the presence of triphenylarsine (TPA). Activation energy and parameters (Ea, ΔH‡, ΔS‡, and ΔG‡) were determined for the reaction and a comparison between ΔH‡ and TΔS‡ values showed that the reaction is entropy-controlled. High values of the activation Gibbs free energy indicated that the reaction was chemically controlled. Also, the large negative value of ΔS‡ implied an associative mechanism.