cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Derivation and validation of a time-dependent risk prediction model for in-hospital mortality
Creators: name: Wong, Jenna Chun-Lay
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Nursing.

description: Accurate risk prediction models for in-hospital mortality are important for unbiased comparisons of hospital performance (by producing risk-adjusted mortality rates) and improved patient outcomes (by identifying high-risk patients in need of special medical attention). No previous risk prediction models have properly used post-admission information to predict risk of death in-hospital. In this study, we used administrative and laboratory data to derive and internally validate a Cox regression model (the "Escobar +" model) that predicts the risk of in-hospital death at any point during the admission. The model had excellent discrimination (c-statistic 0.895,95% confidence interval [CI] 0.889-0.902) and calibration. The Escobar+ model is a powerful risk-adjustment methodology that can be used in studies where the start of observation occurs post-admission. The model could also improve the quality and timeliness of patient care by providing health care workers with highly specific and accurate estimates of in-hospital death risk during the patient's stay.
title: A Paleozoic accretion history
title: igneous and detrital zircon signatures of the Kulutingwak and Danish River formations in the Yelverton Inlet-Phillips Inlet region, Ellesmere Island, Nunavut, Canada
titleType: Subtitle
Creators: name: Koch, Megan M.
Publisher: name: University of Iowa
Year: 2021
Subjects: public abstract

description: Juxtaposition of the composite Pearya terrane with the northern Laurentian margin at Ellesmere Island, Nunavut, Canada is an understudied tectonic event that has significant ramifications for the tectonic histories of other crustal fragments in the circum-Arctic region during the Paleozoic. Two end member models for accretion currently exist: 1) translation and emplacement along a sinistral margin-parallel strike-slip system, or 2) orthogonal collision with the Laurentian margin. Current hypotheses regarding this accretionary event rely upon interpretation of the Kulutingwak formation, an Ordovician sedimentary package often identified as a subduction-related sequence, and the Danish River formation, a laterally continuous unit often cited as a post-accretionary overlap assemblage.
description: Geologic relationships present in the Yelverton Inlet-Phillips Inlet region offer a unique opportunity to understand this accretion event, where the Ordovician Kulutingwak formation separates the crystalline basement of the Pearya terrane from the Silurian Danish River formation. Seventeen igneous and detrital zircon samples were collected from this area for U-Pb and Lu-Hf analysis in order to better characterize the Paleozoic sedimentary packages which underpin current tectonic models. Detrital zircon age distributions from the Kulutingwak formation demonstrate a transition from signatures indicative of the Laurentian margin to those diagnostic of the Pearya terrane in the Late Ordovician. Detrital zircon signatures in the Danish River formation record a dynamic tectonic setting in the Silurian where distinct facies belts with variable provenance signals are preserved. Both units are disturbed by late translation along major northeast-southwest striking structures and included in structural assemblages, exposing the need for additional quantitative data in this complex tectonic system.
Taxonomic revision of the flatfish genera Zebrias Jordan and Snyder, 1900 and Pseudaesopia Chabanaud, 1934 with notes on Aesopia Kaup, 1858 (Pleuronectiformes: Soleidae)
Creators: name: Stephens, Holly R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Evolution and Development.
subject: Biology, Systematic.

description: The taxonomic status of the 25 nominal species of the Indo-Pacific flatfish genus Zebrias (Pleuronectiformes: Soleidae) was revised based on a morphological study of 531 specimens, including 36 type specimens. Two distinct, monophyletic groups were identified differing in the confluence and attachment of the caudal fin to adjacent dorsal and anal fins. Species most closely associated to the type species Pleuronectes zebra were included in the genus Zebrias while the remaining species were assigned to the genus Pseudaesopia to accommodate Zebrias species having a shallowly confluent caudal fin with adjacent fins, among other characters. Ten species are now recognized and re-described in Zebrias while six species are recognized and redescribed in Pseudaesopia. Comprehensive generic definitions and identification keys to species are provided. In addition, the closely related and monospecific genus Aesopia is briefly discussed. Finally, potentially useful characters for a future phylogenetic study are discussed.
Correction to: The Cedar Project: Using Indigenous-specific determinants of health to predict substance use among young pregnant-involved Indigenous women in Canada
Creators: name: Shahram, Sana Z.
name: Bottorff, J. L. (Joan L.), 1950-
name: Oelke, Nelly
name: Dahlgren, Leanne
name: Thomas, Victoria
name: Spittal, Patricia M.
Publisher: name: BioMed Central
Year: 2018

description: After publication of the original article (1) it was noted that the title of this manuscript was incorrect. The title presently reads “The cedar project: using indigenous-specific determinants of health to predict substance use among young pregnant-involved aboriginal women” but should read “The Cedar Project: Using Indigenous-specific determinants of health to predict substance use among young pregnant-involved Indigenous women in Canada”.
The contribution of snow meltwater to the annual export of methyl mercury from temperate shield ecosystems
Creators: name: Bodek, Tamar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Ecology.
subject: Biogeochemistry.

description: Methylmercury (MeHg), the known toxic form of mercury is generally only 1-3% of total mercury (THg) in precipitation. As such it was thought to be an insignificant source to aquatic ecosystems; however, since other forms of mercury can be re-volatilized from the snowpack back to the atmosphere shortly after deposition the proportion and biological significance of MeHg in the snowmelt runoff is indeed an important source to downstream ecosystems. To assess the seasonal contribution of MeHg in runoff to the overall annual load of MeHg, the tributaries of two lakes, Dickie (DE) and Harp (HP) in the Haliburton-Muskoka district of Ontario were sampled on a weekly basis for MeHg, dissolved organic carbon (DOC) and conductivity over two years. Stream discharge was monitored on a continuous basis. In order to assess the amount of MeHg in the snowpack, snow cores from the watersheds were sampled during early spring. Additionally, bulk precipitation samples were collected using a wet-dry automated precipitation collector in the mercury deposition network (MDN) operated station in St. Anicet, Quebec every 4-6 weeks, for 26 months. The samples were analyzed for MeHg, and an annual deposition rate was calculated. THg and MeHg data obtained from the MDN was used to calculate a deposition rate for THg, and the proportion of MeHg. THg in wet deposition was 5.29-6.88 mug m-2 year-1, and MeHg was 0.15-0.19 mug m -2 year-1 and equivalent to 2.7-2.9 % of THg. Although low MeHg concentrations were measured in runoff during spring freshet, the high discharge rates resulted in quantities which were up to 33.9% of the annual amount of MeHg. The seasonal contribution of MeHg in runoff was found to be: spring>summer>fall> winter for the wetland rich DE and fall> spring> winter> summer for the wetland dull HP. Multiple regression analysis illustrated that DOC was the most significant predictor of MeHg (r2=0.32, p<0.01) across all data with a strong seasonal dependence of the DOC-MeHg correlation. The strongest correlation was found during spring freshet (r 2=0.65, p=0.001) followed by summer, winter and fall (r2= 0.37, 0.23 and 0.22 respectively, p<0.05 for all). The constant flow of water during the winter and strong correlation with DOC during snowmelt suggests a terrestrial source of MeHg even during the winter months, however, direct precipitation during spring and snowmelt were also found to contribute to the MeHg load during snowmelt runoff.
title: Serum metabolites and risk of myocardial infarction and ischemic stroke
title: a targeted metabolomic approach in two German prospective cohorts
titleType: Subtitle
Creators: name: Floegel, Anna
name: Kühn, Tilman
name: Sookthai, Disorn
name: Johnson, Theron
name: Prehn, Cornelia
name: Rolle-Kampczyk, Ulrike
name: Otto, Wolfgang
name: Weikert, Cornelia
name: Illig, Thomas
name: Von Bergen, Martin
name: Adamski, Jerzy
name: Boeing, Heiner
name: Kaaks, Rudolf
name: Pischon, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Metabolomics
subject: Myocardial infarction
subject: Stroke
subject: Biomarker
subject: Prospective cohort study
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people. We investigated the association of 105 serum metabolites, including acylcarnitines, amino acids, phospholipids and hexose, with risk of myocardial infarction (MI) and ischemic stroke in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (27,548 adults) and Heidelberg (25,540 adults) cohorts. Using case-cohort designs, we measured metabolites among individuals who were free of CVD and diabetes at blood draw but developed MI (n = 204 and n = 228) or stroke (n = 147 and n = 121) during follow-up (mean, 7.8 and 7.3 years) and among randomly drawn subcohorts (n = 2214 and n = 770). We used Cox regression analysis and combined results using meta-analysis. Independent of classical CVD risk factors, ten metabolites were associated with risk of MI in both cohorts, including sphingomyelins, diacyl-phosphatidylcholines and acyl-alkyl- phosphatidylcholines with pooled relative risks in the range of 1.21–1.40 per one standard deviation increase in metabolite concentrations. The metabolites showed positive correlations with total- and LDL-cholesterol (r ranged from 0.13 to 0.57). When additionally adjusting for total-, LDL- and HDL- cholesterol, triglycerides and C-reactive protein, acyl-alkyl- phosphatidylcholine C36:3 and diacyl-phosphatidylcholines C38:3 and C40:4 remained associated with risk of MI. When added to classical CVD risk models these metabolites further improved CVD prediction (c-statistics increased from 0.8365 to 0.8384 in EPIC-Potsdam and from 0.8344 to 0.8378 in EPIC- Heidelberg). None of the metabolites was consistently associated with stroke risk. Alterations in sphingomyelin and phosphatidylcholine metabolism, and particularly metabolites of the arachidonic acid pathway are independently associated with risk of MI in healthy adults.
Orientation of ordered sets: Their structure and enumeration.
Creators: name: Liu, Wei Ping.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Electronics and Electrical.

description: The aim of this thesis is to enumerate and classify order diagrams. Some new characterizations will be proved. We also obtain new upper bounds and lower bounds, asymptotic estimation and even precise formulas. The proofs use deep ideas from combinatorial optimization, graph theory and the theory of ordered sets. After a brief account of some basic definitions, notation and terminology that will be used in this thesis, we investigate. In Chapter 2, a new and efficient characterization for inversions will be given. In chapter 3, we study two important properties or ordered sets--planarity and s-genus. In Chapter 4, we enumerate the number of reorientations of an ordered set. Some interesting counter examples are provided. In the last chapter, we will consider some problems in computational geometry. To summarize, here are the main new results that will be proved in this thesis. Theorem 2.2.1. An ordered set Q is an inversion of an ordered set P if and only if the reversed edges can be partitioned into cuts. Theorem 2.2.2. There is an algorithm with complexity $O(ISI\sp5)$ to test whether an ordered set is an inversion of another. Theorem 3.2.9. A bipartite ordered set is planar if and only if its covering graph is planar. Theorem 3.3.1. Any n-element outerplanar covering graph has at least $2\sp{\rm n/2}$ planar orientations. Theorem 4.2.1. There is a covering graph G some of whose independent sets cannot be the set of maximal elements of some orientation of G. Theorem 4.2.4. There is an ordered set such that for some matching M and a subset $M\sp\prime$ of M, there is not reorientation which reverses the edges of $M\sp\prime$ and none of M-M$\sp\prime$. Theorem 4.4.1. Almost any n-element covering graph has at least $2\sp{\rm n/3}$ orientations. Theorem 4.4.3. Any n-element planar covering graph has at least $2\sp{\rm n/3}$ orientations. Theorem 4.4.7. Any n-element lattice with girth at least seven has at least $2\sp{\rm n/3}$ orientations.
A conductor's preparatory analysis and comparison of three Regina Coeli settings, K. 108, K. 127, and K. 276, by Wolfgang Amadeus Mozart
Creators: name: Beckmann-Collier, Aimee
Publisher: name: University of Iowa
Year: 1988
Subjects: Choral Music
Classical Music
Music Conducting

description: The purpose of this essay is to examine each of the three "Regina coeli" settings by Wolfgang Amadeus Mozart and to make comparisons among them. Discussion of the sacred choral music of the Classical era, the Salzburg musical establishment and tradition, appropriate performance practices, and the "Regina coeli" text itself will provide the background information necessary for an understanding of and appreciation for these pieces.
description: The short sacred choral works of Wolfgang Amadeus Mozart are among the least known and performed of all of his compositions. Except for the motet Ave verum corpus, K. 618, these twenty-five antiphons, graduals, and offertories written between 1765 and 1791 are seldom mentioned in any discussion of his works.
description: Even Mozart’s larger sacred choral works, such as the Mass in C Major, K. 317 ("Coronation"), the unfinished Mass in C Minor, K. 427, and the Requiem, K. 626, have been largely ignored until recently and often have been criticized for a variety of reasons. Mozart’s sacred choral works, like those of Haydn, have been dismissed as operatic in style and inappropriate for liturgical use. In addition, Mozart's sacred music has been criticized by Charles Rosen, Eric Blom, and other scholars of Classical music as being less skillfully crafted than his work in other genres. But like the other genres in which Mozart began composing at an early age and in which he continued to write through the last years of his life, the sacred works represent his complete style development. Because Mozart wrote them from the age of nine until his death, the sacred choral works reflect the influences of his travels, his association with Padre Martini, the Salzburg tradition in which he was steeped, and the effects of the Enlightenment.
description: Mozart's three "Regina coeli" settings, K. 107 (1771), K. 127 (1772), and K. 276 (1779?) are the only smaller sacred works that demonstrate his attention to the same text at several different points in his compositional life. As such, they serve as examples of his musical development and reflect the many influences on his compositional style. These pieces, like most of Mozart's sacred music, were written for use in Salzburg, and are a synthesis of the south Austrian tradition and the Italian style.
The role of the mitochondrial calcium uniporter in the control of neuronal network excitability and seizure susceptibility
Creators: name: Walters, Grant Christian
Publisher: name: University of Iowa
Year: 2025
Subjects: Calcium
Mitochondria
Mitochondrial Calcium Uniporter
Seizures
public abstract
Synaptic Transmission

description: Epilepsy affects approximately 70 million people worldwide and approximately 30% of those people develop refractory epilepsy, which cannot be controlled by the current available pharmaceutics. Refractory epilepsy increases a person’s risk for sudden unexpected death in epilepsy (SUDEP), which is the leading cause of death in epilepsy patients. Epilepsy is characterized by increased neuronal network excitability and an important aspect of neuronal network regulation are cytosolic Ca2+ levels. Neuronal cytosolic Ca2+ concentrations are regulated by mitochondria which efficiently buffer cytosolic Ca2+ and shape Ca2+ signals. Mitochondrial Ca2+ transport is controlled by a complex of proteins known as the mitochondrial Ca2+ uniporter (MCU) mediates mitochondrial Ca2+ uptake by forming a Ca2+ permeable channel. Deletion of MCU results in impaired Ca2+ uptake into mitochondria in neurons and significantly altered cytosolic Ca2+ signaling. Interestingly, we also found that global MCU deletion resulted in a profound anticonvulsant effect in in vitro epileptiform activity experiments, as well as in mice, where a maximal electroshock seizure threshold (MES) paradigm was used. Electrophysiological experiments revealed increased GABAergic synaptic activity and decreased excitatory synaptic activity in MCU-KO mice. To further determine if the anticonvulsant effect is driven by increased GABAergic signaling, we developed MCU floxed mice and crossed them with pan neuronal specific Synapsin-Cre, excitatory CaMKII-Cre and VGlut1-Cre, and inhibitory VGAT-Cre mice. We determined that pan neuronal and inhibitory neuron specific deletion of MCU resulted in increased MES thresholds, but excitatory specific deletion did not. Collectively, these experiments elucidate the mechanisms that underlie the robust anticonvulsant effects of MCU deletion. The results of these studies begin to provide insights into the role of mitochondrial Ca2+ transport in epilepsy and could guide the development of new therapeutic approaches targeting MCU and other mitochondrial Ca2+ transporters for treatment of epilepsy.
Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation
Creators: name: Hartmann, Bianca
name: Wai, Timothy
name: Hu, Hao
name: MacVicar, Thomas
name: Musante, Luciana
name: Fischer-Zirnsak, Björn
name: Stenzel, Werner
name: Gräf, Ralph
name: Heuvel, Lambert Van Den
name: Ropers, Hans-Hilger
name: Wienker, Thomas F.
name: Hübner, Christoph
name: Langer, Thomas
name: Kaindl, Ange
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Mitochondriopathies often present clinically as multisystemic disorders of primarily high-energy consuming organs. Assembly, turnover, and surveillance of mitochondrial proteins are essential for mitochondrial function and a key task of AAA family members of metalloproteases. We identified a homozygous mutation in the nuclear encoded mitochondrial escape 1-like 1 gene YME1L1, member of the AAA protease family, as a cause of a novel mitochondriopathy in a consanguineous pedigree of Saudi Arabian descent. The homozygous missense mutation, located in a highly conserved region in the mitochondrial pre- sequence, inhibits cleavage of YME1L1 by the mitochondrial processing peptidase, which culminates in the rapid degradation of YME1L1 precursor protein. Impaired YME1L1 function causes a proliferation defect and mitochondrial network fragmentation due to abnormal processing of OPA1. Our results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans.
Does success spawn greed or generosity? Longitudinal reciprocal relationships between career success and agentic and communal goal importance
Creators: name: Ptashnik, Thomas
Publisher: name: University of Iowa
Year: 2025
Subjects: Organizational behavior
public abstract

description: The longitudinal reciprocal relationship between agentic/communal higher-order goals and objective career success has become practically and theoretically relevant as more prosocial individuals enter the workforce and related fields have discovered that individuals are less stable than previously thought. In a study following 11,522 individuals over twelve years of the early stages of their careers, I draw from the TESSERA framework of personality development (Wrzus & Roberts, 2017) to explain why career success should serve as a sufficient stimulus to change individuals’ aspirations (i.e., socialization effects), which in turn can determine future success (i.e., selection effects), as well as investigating gender as a boundary condition. The results from latent change score modeling suggest that the selection effect outweighs the socialization effect, with high-agentic and high-communal individuals experiencing an increase and decrease in subsequent income change, respectively. Nonetheless, the socialization effects were still significant and unexpectedly heightened the importance of both agentic and communal goals. Several additional unanticipated findings were also discovered, such as women having a stronger agentic selection effect than men and agentic and communal goals being independent of each other. Taken together, individuals who experience success early into their work tenure were found to grow their future income and, more slowly, the desire to help others and have more achievements. In contrast, individuals with high communal goals at the start of their careers paradoxically were more likely to sacrifice the ability to materially help others while subsequently downgrading their own communal desires, whereas early attention on success begets success. These findings demonstrate the fundamental drive to have congruence between one’s work situation and desires, as well as the evolving nature of a person at the onset of their career.
Free vibration of partially supported plates and shells.
Creators: name: Alizadeh, Y.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Mechanical.

description: First-order transverse shear-deformation Mindlin theory has been used to predict the free vibration frequencies and modal shapes for isotropic, laminated and composite plates or shells. A finite element model based on the small deflection linear theory has been developed to obtain numerical solutions for this class of problems. The results for some of the degenerate cases are compared with other results available in the literature. These analyses involve a wide number of variables, namely; material properties, aspect ratios, support conditions and also radius to base ratio. The cracked base plates, shells and blades are idealized as partially supported models with varying support lengths. The effects of the detached base length on natural frequencies, modal shapes and nodal lines of these types of structures are investigated. Although the expected decrease in frequency with increase in the detached base length is observed almost for all modes it is seen that this behavior is very pronounced for higher modes in both plates and shells. Analysis also showed that the variation of the detached base length has a small effect on the natural frequencies of plates and shells with large aspect ratios ( b/a > 2, r/a > 2).
3D adaptive mesh refinement simulations of the gas cloud G2 born within the disks of young stars in the galactic center
Creators: name: Schartmann, Marc
name: Ballone, A.
name: Burkert, A.
name: Gillessen, S.
name: Genzel, R.
name: Pfuhl, O.
name: Eisenhauer, F.
name: Plewa, P. M.
name: Ott, T.
name: George, E. M.
name: Habibi, M.
Publisher: name: Swinburne
Year: 2024

description: The dusty, ionized gas cloud G2 is currently passing the massive black hole in the Galactic Center at a distance of roughly 2400 Schwarzschild radii. We explore the possibility of a starting point of the cloud within the disks of young stars. We make use of the large amount of new observations in order to put constraints on G2's origin. Interpreting the observations as a diffuse cloud of gas, we employ three-dimensional hydrodynamical adaptive mesh refinement (AMR) simulations with the PLUTO code and do a detailed comparison with observational data. The simulations presented in this work update our previously obtained results in multiple ways: (1) high resolution three-dimensional hydrodynamical AMR simulations are used, (2) the cloud follows the updated orbit based on the Brackett-γ data, (3) a detailed comparison to the observed high-quality position-velocity (PV) diagrams and the evolution of the total Brackett-γ luminosity is done. We concentrate on two unsolved problems of the diffuse cloud scenario: the unphysical formation epoch only shortly before the first detection and the too steep Brackett-γ light curve obtained in simulations, whereas the observations indicate a constant Brackett-γ luminosity between 2004 and 2013. For a given atmosphere and cloud mass, we find a consistent model that can explain both, the observed Brackett-γ light curve and the PV diagrams of all epochs. Assuming initial pressure equilibrium with the atmosphere, this can be reached for a starting date earlier than roughly 1900, which is close to apo-center and well within the disks of young stars.
Acute psychophysiological stress impairs human associative learning
Creators: name: Ehlers, Mana R.
name: Todd, Rebecca M.
Publisher: name: The University of British Columbia
Year: 2020

description: Addiction is increasingly discussed as a disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions towards more habitual ones. However, it remains to be investigated how acute stress may influence simple associative learning processes that occur before a habit can be established. In the present study, healthy young adults were exposed to either acute stress or a control condition half an hour before performing simple classical and operant conditioning tasks. Psychophysiological measures confirmed successful stress induction. Results of the operant conditioning task revealed reduced instrumental responding under delayed acute stress that resembled behavioral responses to lower levels of reward. The classical conditioning experiment revealed successful conditioning in both experimental groups; however, explicit knowledge of conditioning as indicated by stimulus ratings differentiated the stress and control groups. These findings suggest that operant and classical conditioning are differentially influenced by the delayed effects of acute stress with important implications for the understanding of how new habitual behaviors are initially established.
Die Umweltwirtschaft in Deutschland
Creators: name: Eckermann, Frauke
Publisher: name: Umweltbundesamt
Year: 2017
Subjects: subject: Umweltwirtschaft
subject: Umweltschutzgüter
subject: Umweltschutzwirtschaft
subject: Umwelttechnologie
subject: Wirtschaft | Konsum

description: Welche Bedeutung haben Güter, die für Umweltschutzzwecke eingesetzt werden können, für die deutsche Wirtschaft? Wie steht Deutschland als Exporteur von Umweltschutzgütern international da? Und wie haben sich die einzelnen Branchen in den letzten Jahren entwickelt? Dieses Hintergrundpapier liefert Daten für die Jahre 2002 bis 2015.
Benchmarking af Øresund som cykelregion
Creators: name: Jepsen, Søren Fischer
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Inden for rammerne af Interreg IVA programmet om Cykling i Øresundsregionen er der foretaget både en intern benchmarking af byerne i Øresundsregionen og en ekstern benchmarking, hvor Øresundsregionen blev sammenlignet med udvalgte regioner i Holland og Tyskland. Cykel forholdene internt i Øresundsregionen er kortlagt gennem en beskrivende analyse af rejsevaner fra de nationale danske og svenske rejsevaneundersøgelser. For at få beskrevet kommunernes interne arbejde med cykeltrafik er der udsendt et spørgeskema. Resultaterne fra de to undersøgelser viser en høj grad af sammenlignelighed på tværs af sundet, både hvad angår cykelandele, og omfanget af de kommunale indsatser på området. Den eksterne benchmarking er endnu ikke afsluttet, men de foreløbige resultater viser nogle interessante forskelle i cykelandele. Hvor cykling i Øresundsregionen i høj grad er knyttet op på de større byer, er cyklingen i de udvalgte regioner i hverken Holland eller Tyskland bundet op på bystørrelsen, her cykler alle lige meget uanset om de bor i byerne eller på landet.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Alkylation treatment of the Mexican Axolotl: An approach to the induction of new mutations.
Creators: name: Ortiz, Maria Fernanda.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: Biology, Molecular.

description: In order to obtain new mutants in the axolotl, Ambystoma mexicanum, that could be used for future genetic studies, EMS treatments have been given to adult females. Our results indicate a reduced fertility among the eggs from treated females, as well as increased lethality during embryonic development. Abnormal larvae have been obtained from these embryos. Whether we have succeeded in inducing new mutations, or whether the abnormalities are only due to the teratogenic effects of the EMS, still has to be tested when the animals mature. No external signs of haploidy have been observed among these larvae, except in one case. Tail-tip squashes of this larva revealed the normal number of nucleoli. Superovulation has not been observed among the treated females. Instead, our results suggest that EMS is suppressing ovulation. To pinpoint the effects of EMS on germ cells, treatment of various concentrations have been given to mature, spawned sperm. The sperm were used to artificially inseminate newly laid eggs. Our results show that increasing concentrations of EMS reduce the fertility of eggs inseminated with treated sperm. DNA isolated from 3H-EMS treated sperm has shown approximately 1 ethylation per 1,000 nucleotides. In spite of this, abnormalities have not been observed among embryos from EMS treated sperm, and therefore, no increased lethality has been obtained. The possibility that dominant lethal induction by EMS, in the axolotl, is due to damage of extranuclear components is discussed. Possible experiments that would bring some light to this subject are proposed.
Evaluation of aerosols in a simulated orthodontic debonding procedure
Creators: name: Eckermann, Nile Louis
Publisher: name: University of Iowa
Year: 2022
Subjects: Aerosol
coronavirus
debond
MS2 bacteriophage
plaque assay
public abstract
Orthodontics

description: Introduction:
description: The COVID-19 pandemic has raised many concerns with regards to transmission of viral particles through the aerosols generated during dental procedures. There are many unanswered questions regarding this concern, especially in an orthodontic setting. The objective of this study is to quantify the volume of MS2 bacteriophage viral copies, a surrogate virus for SARS-CoV-2, in a simulated procedure on a dental mannequin, during orthodontic debonding procedure without water.
description: Methods:
description: A simulated orthodontic deband was performed (n=10) on a dental mannequin with high-speed suction, but without water. Prior to composite removal, the facial surface of all typodont teeth were coated with 1 mL of PBS buffer containing MS2. Optical particle counters were used to measure particle concentration, while simultaneously, air samplers (SKC Biosampler) were used to collect virus aerosol generated by the procedure near the oral cavity of the mannequin and behind the clinician’s face shield. Double layer plaque assay with pour plate technique was used for enumeration of MS2 concentrations (PFU/m3) to determine the viable virus airborne concentration. Results:
description: This study included 8 successful trials (2 trials discarded due to plaque assay contamination) with each trial consisting of biosampler measurements near the oral cavity of the dental mannequin and behind the face shield of the operator. MS2 concentrations were consistently detected near the mannequin mouth and behind the face shield in the breathing zone of the operator. The average concentration of the viral particles, enumerated by double layer plaque assay, was 8.46x106 PFU/m3 near the mouth and 1.15x106 PFU/m3 behind the face shield in the breathing zone of the operator. There was no statistically significant difference between virus concentrations measured near the mouth and behind the face shield (P>0.05). There was no significant difference in the mean particle size distribution at either sampling location (P>0.05). Conclusion:
description: These results suggest that a face shield does not provide increased protection from live virus aerosol during deband procedures. This information demonstrates that virus aerosol exposures may persist during common procedures. Further efforts are needed to guide our profession and provide adequate health protection for dental providers and patients from exposures to virus aerosols.
Transportformer og indkøb
Creators: name: Larsen, Anja
name: Herby, Jonas
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Formålet med undersøgelsen var at opnå større viden i dansk sammenhæng om indkøbsvaner, transportformer og parkeringsforhold, herunder blandt andet bevæggrunde til valg af transportform og beløb forbrugt fordelt på transportformer. Undersøgelsen viste blandt andet, at: • I København handles der årligt for ca. 18 mia. kr. på cykel, 12 mia. kr. til fods, 9 mia. kr. med offentlig transport og 22 mia. kr. i bil. Der foretages næsten dobbelt så mange indkøbsture på cykel som i bil. Til gengæld handler bilister for mere på den enkelte indkøbstur (specielt i butikscentre). • Investeringer i cykelparkering kan potentielt overflytte ca. 900 indkøbsture foretaget af københavnere, i København, fra bil til cykel. Det vil reducere CO2 med knap 200 tons om året. • Der største potentiale for flere cyklister ligger i forbedret infrastruktur. Som fx vedligeholdelsen og bredden af cykelstier.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
1000 gule cyklister
Creators: name: Andersen, Troels
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Fredericia ønsker på linje med mange andre danske byer at få flere op på cyklen. Målet er en cykelandel på 25 %, som kræver nye og effektive tiltag. Arbejdspladserne kan være en vanskelig målgruppe, da mange har problemer i relation til tid og afstand. Det kan være svært at tiltrække nye cyklister i denne gruppe, da vanerne ofte er meget faste. Formålet var at aktivere en stor del af målgruppen inden for kort tid. Initiativet skulle give stor omtale og dermed et potentiale for afledte effekter. Projektet skal kunne overføres til andre byer og skal umiddelbart kunne gentages som en fast årlig begivenhed. Fredericia har tidligere kørt en kampagne med ’Jorden rundt på 80 dage’ for skolebørn, hvor det tekniske omdrejningspunkt var brug af GPS enheder med upload til en hjemmeside og en historiefortælling i relation til rejsen. Projektet opnåede rigtig gode resultater med stort deltagerengagement. Dette projekt benytter de samme gule GPS enheder, men i en voksen kontekst. Team Rynkeby har vist vejen, men her opbygges et koncept blandt almindelige mennesker og integreret i hverdagen – cykelstafetten.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Regulator of G protein signaling 6 (RGS6), a critical modulator of neurological function and disease
Creators: name: Spicer, Mackenzie Marie
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract

description: G coupled-protein receptor (GPCR) signaling is involved in virtually every known physiological process, and dysfunction in GPCR signaling is linked to many human diseases. GPCRs critically regulate pre- and post-synaptic neurotransmission, and changes in GPCR regulation can significantly impact synaptic plasticity and subsequent neuronal activity and communication. Regulators of G protein signaling (RGS) proteins negatively regulate GPCR signaling by accelerating GTP hydrolysis and reassociating the heterotrimeric G protein complex to terminate downstream signaling. Thus, RGS proteins critically modulate both the duration and magnitude of GPCR signaling. RGS6 is an R7 RGS protein that negatively regulates GPCR-Gαi/o signaling and is highly expressed in the brain. RGS6 is one of 23 genes involved in pleiotropic neuropsychiatric disorders in humans, and previous studies in our lab using mice with global loss of RGS6 documented its role in Parkinson’s disease (PD)-like neurodegeneration and alcohol reward and dependence. Subsequent studies in humans implicated RGS in Alzheimer’s Disease (AD), PD and alcohol use disorders (AUDs).
description: Here, we elucidate RGS6’s roles in these neurodegenerative and neuropsychiatric diseases by using novel RGS6 floxed mice to allow for Cre-dependent neuron-specific deletion of RGS6. We discovered that RGS6 is expressed in the dentate gyrus of human AD patients and mice, and its expression mediates the complete recovery of hippocampal learning and memory deficits by voluntary running in a mouse model of AD. Additionally, we found that RGS6 expression in substantia nigra dopamine neurons promotes their survival and proper motor function, as RGS6 loss in x these neurons produces a PD-like phenotype in mice. Finally, we discovered that RGS6 is also expressed in dopamine neurons in the ventral tegmental area of humans and mice where it promotes alcohol consumption and reward behaviors in mice. Together, these data have identified RGS6 as a critical modulator of neurological function and disease.
Étude de la perception qu'ont les pères de leur participation aux soins de leurs enfants d'âge préscolaire, selon une perspective motivationnelle.
Creators: name: Bouchard, Geneviève.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Education, Educational Psychology.

description: La présente thèse a pour objectif d'appliquer la théorie de l'autodétermination (Deci & Ryan, 1985, 1991) au contexte de la participation des pères aux soins de leurs enfants. Un modèle de prédiction a été est formulé, combinant la perception qu'ont les pères de certains facteurs individuels et interpersonnels pertinents à leur engagement parental. Une première étude menée auprès de pères de families à deux revenus ( N = 110) ayant un enfant d'âge préscolaire (âgé entre 2 et 5 ans), a permis de démontré des propriétés psychométriques satisfaisantes pour quatre échelles développées, évaluant: (1) la perception de la participation des pères aux soins des enfants (ÉPSE), (2) la motivation des pères envers leur participation (ÉMPE), (3) la perception des comportements interpersonnels de la conjointe devant le rôle du père (ÉCIC) et (4) la perception de compétence parentale (ÉCP). Le modèle de prédiction a été vérifié auprès d'un deuxième échantillon de pères de families à deux revenus ( N = 205) ayant au moms un enfant d'âge préscolaire (âgé entre 2 et 6 ans), au moyen d'analyses par équations structurales. Les résultats présentent ces pères qui se perçoivent engagés et compétents daps leur rôle, soutenus par leer conjointe daps leur rôle, motivés dune façon autodéterminée et satisfaits de leer expérience. Les résultats ont soutenu daps l'ensemble le modèle proposé. Au sein du modèle final, la perception qu'ont les pères du soutien à leur compétence de leur conjointe était reliée positivement à leur compëtence parentale, cette dernière variable était ensuite reliée positivement à leur motivation. La perception qu'ont les pères du soutien interpersonnel de leur conjointe était reliée positivement à leur motivation. La motivation était ensuite reliée positivement à leur perception de participation aux soins de leurs enfants et à leur satisfaction parentale. Cette thèse offre une contribution théorique à l'étude des pères, tout en élargissant l'application de la théorie de l'autodétermination à un domaine d'activité relationnel. Les répercussions théoriques et appliquées de cette thèse sont présentées, suivis de certaines limites inhérentes aux résultats, ainsi que des perspectives d'avenir.
Cobalt-catalyzed oxidation of activated hydrocarbons under an atmosphere of oxygen.
Creators: name: Li, Pei.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Chemistry, Inorganic.

description: Liquid phase oxidation of organic substrates under an atmosphere of oxygen catalyzed by metal complexes is reviewed in Chapter 1. Also included in the review are homogeneous and heterogeneous catalysis and free radical autoxidation reactions. The selective catalytic oxidation of aromatic hydrocarbons is described in Chapter 2. Anhydrous CoCl$\sb2$, CoCl$\sb2$/CrCl$\sb3$, or CoCl$\sb2$/ZrCl$\sb4$ were used as the catalysts to oxidize a variety of substrates in the presence of diglyme or a mixture of diglyme and MEK (1:3). These substrates included substituted toluenes and other benzylic hydrocarbons. The reactions afforded fair to excellent yields of the product aldehydes or ketones under mild conditions. It was discovered that the selectivity of these reactions is strongly influenced by the catalyst and the solvent. Selective catalytic oxidation of ethers and cyclic acetals using cobalt chloride is described in Chapter 3. The oxidation of cyclic ethers gives the corresponding lactones in reasonable to excellent yields. However, 2,3-dihydrobenzofuran leads to no reaction. Oxidation of acyclic alkyl benzyl ethers to the corresponding esters afforded yields which were dependent on the stability of the alkyl radicals. The more stable the alkyl radical, the lower the yield of the ester obtained. In addition, oxidation of acyclic and heterocyclic ethers is described. An investigation of the reaction mechanism of this process was also studied. Finally, the oxidation of 2-substituted 1,3-dioxolanes afforded high yields of formate esters and acids. It was found that the presence of catalytic amounts of ZnCl$\sb2$ promoted the rate of oxidation.
Samfundsøkonomisk vurdering af ”Vi cykler på arbejde”-kampagnen
Creators: name: Willumsen, Eva
name: Duer, Henrik
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: "Vi cykler til arbejde"-kampagnen sigter mod at få flere personer til at vælge cyklen som transportmiddel. Analysen peger på, at "Vi cykler til arbejde"-kampagnen er en samfundsøkonomisk særdeles god forretning. Således giver analysen med brug af de centrale antagelser og forudsætninger en nettonutidsværdi på 43 mio. kr. Den suverænt største gevinst ved kampagnen er sundhedsgevinsterne, men reduktion af trængsel udgør også en relativt stor gevinst. Opgørelsen af sundhedsgevinsterne er baseret på indledende opgørelser af gevinsterne ved motion, som er forbundet med væsentlig usikkerhed. Der er envidere usikkerhed forbundet med opgørelsen af , hvor meget kampagnen øger cykelomfanget, og hvor lang tid effekten varer. De gennemførte følsomhedsanalyser med variation i de øvrige centrale forudsætninger og inputdata udviser generelt relativt robuste resultater for den samfundsøkonomiske analyse.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
title: Partisan trust
title: how political parties determine levels of popular trust in institutions
titleType: Subtitle
Creators: name: Qabazard, Ahmad S
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract

description: This dissertation explores the role of political parties in polarizing political trust. The gap in political trust between electoral winners and losers threatens regime stability, undermines accountability, and casts doubt on the idea of trust as a reservoir of political support. Although previous work that examines the determinants of the winner-loser gap in political trust has focused on electoral institutions, I argue that an analysis of parties, their behavior, and who they descriptively represent sheds light on why trust is polarized in some societies more than others. By focusing on parties and party systems, I argue that political parties act as intermediaries that influence attitudes toward institutions and the rules that govern them. Building on literature that identifies the cognitive and affective dimensions of trust judgments, I argue that partisans are influenced by perceptions of how institutions and agents will act. In this dissertation, I explore ways parties can shape cognitive and affective dimensions of trust judgments.
High-Throughput Alloy Development Using Advanced Characterization Techniques During Directed Energy Deposition Additive Manufacturing
Creators: name: Sommer, Niklas
name: Bauer, André
name: Kahlmeyer, Martin
name: Wegener, Thomas
name: Degener, Sebastian
name: Liehr, Alexander
name: Bolender, Artjom
name: Vollmer, Malte
name: Holz, Hendrik
name: Zeiler, Stefan
name: Merle, Benoit
name: Niendorf, Thomas
name: Böhm, Stefan
Publisher: name: Universität Kassel
Year: 2023
Subjects: subject: additive manufacturing
subject: alloy development
subject: direct energy deposition
subject: in situ characterization
subject: 620
subject: Rapid Prototyping
subject: Legierungselement

description: Gefördert im Rahmen des Projekts DEAL