cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study
Creators: name: Helsten, Teresa
name: Becerra, Carlos
name: Manuel, Allison M.
name: Kalinsky, Kevin
name: Beeram, Muralidhar
name: Dees, E. Claire
name: Tolaney, Sara M.
name: Lithio, Andrew
name: Price, Gregory L.
name: Litchfield, Lacey M.
name: Moore, Kathleen N.
name: Rexer, Brent N.
name: Beck, J. Thaddeus
name: Goetz, Matthew P.
name: Jhaveri, Komal
name: Burris, Howard A.
name: Chapman, Sonya C.
name: Conlin, Alison
name: Puhalla, Shannon L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Background Cyclin-dependent kinases (CDK) 4 and 6 regulate G1 to S cell cycle progression and are often altered in cancers. Abemaciclib is a selective inhibitor of CDK4 and CDK6 approved for administration on a continuous dosing schedule as monotherapy or as combination therapy with an aromatase inhibitor or fulvestrant in patients with advanced or metastatic breast cancer. This Phase 1b study evaluated the safety and tolerability, pharmacokinetics, and antitumor activity of abemaciclib in combination with endocrine therapy for metastatic breast cancer (MBC), including aromatase inhibitors (letrozole, anastrozole, or exemestane) or tamoxifen. Patients and Methods Women ≥18 years old with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) MBC were eligible for enrollment. Eligibility included measurable disease or non-measurable but evaluable bone disease by Response Evaluation Criteria in Solid Tumours (RECIST) v1.1, Eastern Cooperative Oncology Group performance status 0–1, and no prior chemotherapy for metastatic disease. Adverse events were graded by the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 and tumor response were assessed by RECIST v1.1. Results Sixty-seven patients were enrolled and received abemaciclib 200 mg every 12 hours in combination with letrozole (Part A, n=20), anastrozole (Part B, n=16), tamoxifen (Part C, n=16), or exemestane (Part D, n=15). The most common treatment-emergent adverse events (TEAE) were diarrhea, fatigue, nausea, and abdominal pain. Grade 4 TEAEs were reported in five patients (one each with hyperglycemia, hypertension, neutropenia, procedural hemorrhage, and sepsis). There was no effect of abemaciclib or endocrine therapy on the pharmacokinetics of any combination study drug. Across all treated patients, the median progression-free survival was 25.4 months (95% confidence interval: 18.0, 35.8). The objective response rate was 38.9% in 36 patients with measurable disease. Conclusions Abemaciclib in combination with multiple endocrine therapy options exhibited manageable safety and promising antitumor activity in patients with HR+, HER2- MBC. Clinical Trial Registration https://clinicaltrials.gov/, identifier NCT02057133
title: Accessibility in Web Modeling Tools: Systematic Review and Conceptualization of a Keyboard-Only Prototype
Creators: name: Sarioğlu, Aylin
Publisher: name: TU Wien
Year: 2023
Subjects: subject: conceptual modeling
subject: accessibility
subject: web modeling
subject: model engineering
subject: GLSP

description: According to the World Health Organization, the number of disabilities is increasing steadily. Additionally, as the internet has become a fundamental aspect of our daily lives, it is essential to ensure that all individuals, regardless of their abilities, have equal access to different information and services. Despite a growing effort to promote inclusion worldwide, there are still inaccessible tools and technologies in the field of computation. This results in unequal access to information systems and products for many people with disabilities. Consequently, accessibility should also be a key element, particularly in conceptual modeling, since web modeling tools have grown in popularity, as these tools have become essential in various fields, allowing professionals to work together, create, and build intricate web-based systems. In this regard, web accessibility is crucial for web modeling tools, as it ensures that users with disabilities can contribute fully to the modeling process and have equal chances to benefit.This thesis presents existing web accessibility issues in conceptual modeling research by identifying current research gaps and delineating a vision toward more inclusive, i.e., disability-aware conceptual modeling, based on a systematic review of the literature and current modeling tools. One key finding relates to a gap in research and tool support concerning physical disabilities. Based on these results, this thesis presents the first modeling prototype that can be used keyboard-only, thereby including users with physical disabilities to engage in conceptual modeling.
(502014) Margaret [Banks]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Learning to simulate precipitation with supervised and generative learning models
Creators: name: Gonzalez, Carlos Gomez
name: Maronda, Kim Serradell
name: Donat, Markus
Publisher: name: Zenodo
Year: 2020
Subjects: artificial intelligence
machine learning
hpc

description: Poster presented in the Virtual Event: ECMWF-ESA Workshop on Machine Learning for Earth System Observation and Prediction.
(502015) Elizabeth Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Impact of Social Network Media Performance in Academic Environment
Creators: name: Raj, Sebastiyan
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 441005
subject: Social theory

description: Since the tremendous growth of the internet, the social networking media have become an essential part in the everyday life of academic people. This study tries to find and fill the gap between the teaching and learning in the academic culture of engineering institution by selecting the best social network media to promote and develop online quality content of educational resources. This kind of study pulse the mentality of academic student in private engineering institution through structural questionnaire survey method have been taken and made the best situation solution. The study recommends that academic students should record scholarly accomplishment of gigantic against successive accessing social network media
Radio--Far infrared correlation in "blue cloud" galaxies with 0
Creators: name: Basu, Aritra
name: Wadadekar, Yogesh
name: Beelen, Alexandre
name: Singh, Veeresh
name: Archana, K. N.
name: Sirothia, Sandeep
name: Ishwara-Chandra, C. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the radio--far infrared (FIR) correlation in "blue cloud" galaxies chosen from the PRism MUltiobject Survey (PRIMUS) up to redshift ($z$) of 1.2 in the XMM-LSS field. We use rest-frame emission at 1.4 GHz in the radio and both monochromatic (at 70$μ$m) and bolometric (between $8-1000~μ$m) emission in the FIR. To probe the nature of the correlation up to $z\sim1.2$, where direct detection of blue star-forming galaxies is impossible with current technology, we employ the technique of image stacking at 0.325 and 1.4 GHz in the radio and in six infrared bands, viz. 24, 70, 160, 250, 350 and $500~μ$m. For comparison, we also study the correlation for more luminous galaxies that are directly detected. The stacking analysis allows us to probe the radio--FIR correlation for galaxies that are up to 2 orders of magnitude fainter than the ones detected directly. The $k-$correction in the infrared wavebands is obtained by fitting the observed spectral energy distribution (SED) with a composite mid-IR power law and a single temperature greybody model. We find that the radio luminosity at 1.4 GHz ($L_{\rm 1.4GHz}$) is strongly correlated with monochromatic FIR luminosity at 70 $μ$m ($L_{\rm 70μm}$) having slope $1.09\pm0.05$ and with bolometric luminosity ($L_{\rm TIR}$) having slope $1.11\pm0.04$. The quantity $q_{\rm TIR} (=\log_{10}[L_{\rm TIR}/(3.75\times 10^{12} L_{\rm 1.4 GHz})])$ is observed to decrease with redshift as $q_{\rm TIR} \propto (1+z)^{-0.16\pm0.03}$ probably caused due to the non-linear slope of the radio--FIR correlation. Within the uncertainties of our measurement and the limitations of our flux-limited and color-selected sample, we do not find any evolution of the radio--FIR correlation with redshift.
description: 17 pages, 8 figures. Accepted to be published in Astrophysical Journal
Cervicovaginal Microbiota Predicts Neisseria gonorrhoeae Clinical Presentation
Creators: name: Macintyre, Andrew N.
name: Seña, Arlene C.
name: Waltmann, Andreea
name: Sempowski, Gregory D.
name: Duncan, Joseph A.
name: Lovett, Angela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Neisseria gonorrhoeae infection of the female lower genital tract can present with a spectrum of phenotypes ranging from asymptomatic carriage to symptomatic cervical inflammation, or cervicitis. The factors that contribute to the development of asymptomatic or symptomatic infections are largely uncharacterized. We conducted a pilot study to assess differences in the cervicovaginal microbial community of patients presenting with symptomatic vs. asymptomatic N. gonorrhoeae infections to a sexually transmitted infections (STI) clinic. DNA was isolated from cervicovaginal swab specimens from women who tested positive for N. gonorrhoeae infection using a clinical diagnostic nucleic acid amplification test. We performed deep sequencing of 16S ribosomal RNA gene amplicons, followed by microbiome analyses with QIIME, and species-specific real-time PCR to assess the composition of microbial communities cohabitating the lower genital tract with the infecting N. gonorrhoeae. Specimens collected from asymptomatic individuals with N. gonorrhoeae infection and no co-infection with Chlamydia trachomatis and/or Trichomonas vaginalis carried Lactobacillus-dominant microbial communities more frequently than symptomatic patients without co-infection. When compared to asymptomatic individuals, symptomatic women had microbial communities characterized by more diverse and heterogenous bacterial taxa, typically associated with bacterial vaginosis (BV) [Prevotella, Sneathia, Mycoplasma hominis, and Bacterial Vaginosis-Associated Bacterium-1 (BVAB1)/“Candidatus Lachnocurva vaginae”]. Both symptomatic and asymptomatic N. gonorrhoeae patients with additional STI co-infection displayed a BV-like microbial community. These findings suggest that Lactobacillus-dominant vaginal microbial community may protect individuals from developing symptoms during lower genital tract infection with N. gonorrhoeae.
(502009) James Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502011) Ellinor Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Couple Communication in Cancer: Protocol for a Multi-Method Examination
Creators: name: Burns, John
name: Baucom, Brian R. W.
name: Baucom, Donald H.
name: Ramos, Katherine
name: Bolger, Niall
name: Gralow, Julie
name: Todd, Michael
name: Weber, Danielle M.
name: Bricker, Jonathan B.
name: Westbrook, Kelly
name: Leo, Karena
name: Zafar, S. Yousuf
name: Romano, Joan M.
name: Syrjala, Karen L.
name: Porter, Laura S.
name: Ghosh, Neeta
name: Langer, Shelby L.
name: Fischer, Melanie S.
name: Strauman, Timothy
name: Shankaran, Veena
name: Keefe, Francis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being.
(502012) Henry Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Biobank perspectives 3:2016
Creators: name: Centre For Research Ethics & Bioethics
Publisher: name: Zenodo
Year: 2016

description: We have worked with the ethical and legal aspects of biboank and registry research for more than a decade. With the aid of BBMRI.se we were able to share our perspectives with the biobank community through the biobank perspectives newsletter that was issued three times a year between 2014 and 2017.
Node Failure Time and Coverage Loss Time Analysis for Maximum Stability Vs Minimum Distance Spanning Tree based Data Gathering in Mobile Sensor Networks
Creators: name: Meghanathan, Natarajan
name: Mumford, Philip
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: A mobile sensor network is a wireless network of sensor nodes that move arbitrarily. In this paper, we explore the use of a maximum stability spanning tree-based data gathering (Max.Stability-DG) algorithm and a minimum-distance spanning tree-based data gathering (MST-DG) algorithm for mobile sensor networks. We analyze the impact of these two algorithms on the node failure times and the resulting coverage loss due to node failures. Both the Max.Stability-DG and MST-DG algorithms are based on a greedy strategy of determining a data gathering tree when one is needed and using that tree as long as it exists. The Max.Stability-DG algorithm assumes the availability of the complete knowledge of future topology changes and determines a data gathering tree whose corresponding spanning tree would exist for the longest time since the current time instant; whereas, the MST-DG algorithm determines a data gathering tree whose corresponding spanning tree is the minimum distance tree at the current time instant. We observe the Max.Stability-DG trees to incur a longer network lifetime (time of disconnection of the network of live sensor nodes due to node failures), a larger coverage loss time for a particular fraction of loss of coverage as well as a lower fraction of coverage loss at any time. The tradeoff is that the Max.Stability-DG trees incur a lower node lifetime (the time of first node failure) due to repeated use of a data gathering tree for a longer time.
description: 16 pages, 11 figures
Identification of RING E3 pseudoligases in the TRIM protein family.
Creators: name: Dudley-Fraser, Jane
name: Esposito, Diego
name: McPhie, Katherine A
name: Morley-Williams, Coltrane
name: Auchynnikava, Tania
name: Rittinger, Katrin
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Structural Biology & Biophysics
subject: Structural Biology & Biophysics
classificationCode: Cell Biology
subject: Cell Biology

description: TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain. However, recent reports have shown that some TRIMs lack detectable ubiquitination activity in isolation, despite containing a RING domain. Here, we present parallel in cellulo, in vitro, and in silico structure-function analyses of the ubiquitin E3 ligase activity and RING domain structural characteristics of the whole TRIM protein family. In-depth follow-up studies of this comprehensive dataset reveals a number of 'pseudoligases', whose RING domains have structurally diverged at either the homodimerisation or E2~ubiquitin interfaces, thereby disrupting their ability to catalyse ubiquitin transfer. Together, these data raise intriguing open questions regarding the unknown TRIM functions in physiology and disease.
Self-Gravitating Spherically Symmetric Solutions in Scalar-Torsion Theories
Creators: name: Kofinas, Georgios
name: Papantonopoulos, Eleftherios
name: Saridakis, Emmanuel N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We studied spherically symmetric solutions in scalar-torsion gravity theories in which a scalar field is coupled to torsion with a derivative coupling. We obtained the general field equations from which we extracted a decoupled master equation, the solution of which leads to the specification of all other unknown functions. We first obtained an exact solution which represents a new wormhole-like solution dressed with a regular scalar field. Then, we found large distance linearized spherically symmetric solutions in which the space asymptotically is AdS.
description: 26 pages
(502010) Jane Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Scaling Up Patient-Centered Psychological Treatments for Perinatal Depression in the Wake of a Global Pandemic
Creators: name: Meltzer-Brody, Samantha
name: Silver, Richard K.
name: Singla, Daisy R.
name: Savel, Katarina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: There is a call to action to reduce the public health burden of perinatal depression worldwide. The COVID-19 pandemic has further highlighted significant gaps in perinatal mental health care, especially among women who identify as Black, Indigenous, People of Color (BIPOC). While psychotherapeutic (cognitive, behavioral and interpersonal) interventions are endorsed for perinatal mood disorders, barriers to access and uptake contribute to inequitable access to treatment at the population level. To effectively address these barriers and increase the scalability of psychotherapy among perinatal women, we suggest four pragmatic questions to be answered from a patient-centered lens; namely, “who,” “what,” “how,” and “when.” Promising avenues include task-sharing among mental health non-specialists, an emphasis on culturally sensitive care, web-based delivery of psychotherapy with some caveats, and a lifespan approach to perinatal mental health. Innovative research efforts are seeking to validate these approaches in diverse contexts across North America and the UK, lending optimism toward scalable and long-term solutions for equitable perinatal mental health care.
Ruled nodal surfaces of Laplace eigenfunctions and injectivity sets for the spherical mean Radon transform in $\mathbb R^3.$
Creators: name: Agranovsky, Mark
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 35P, 44A12

description: It is proved that if a Paley-Wiener family of eigenfunctions of the Laplace operator in $\mathbb R^3$ vanishes on a real analytically ruled two-dimensional surface $S \subset \mathbb R^3$ then $S$ is a union of cones, each of which is contained in a translate of the zero set of a nonzero harmonic homogeneous polynomial. If $S$ is an immersed $C^1-$ manifold then $S$ is a Coxeter system of planes. Full description of common nodal sets of the Laplace spectra of convexly supported distributions is given. In equivalent terms, the result describes ruled injectivity sets for the spherical mean transform and confirms, for the case of ruled surfaces in $\mathbb R^3,$ a conjecture of E.T. Quinto and the author .
description: A few references are added
Sonnenfleckenzeichnung Nr. 222.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.09.1985, 08:00, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 211.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.09.1985, 09:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
(502005) Eliza Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hall and field-effect mobilities in few layered $p$-WSe$_2$ field-effect transistors
Creators: name: Pradhan, N. R.
name: Rhodes, D.
name: Memaran, S.
name: Poumirol, J. M.
name: Smirnov, D.
name: Talapatra, S.
name: Feng, S.
name: Perea-Lopez, N.
name: Elias, A. L.
name: Terrones, M.
name: Ajayan, P. M.
name: Balicas, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Here, we present a temperature ($T$) dependent comparison between field-effect and Hall mobilities in field-effect transistors based on few-layered WSe$_2$ exfoliated onto SiO$_2$. Without dielectric engineering and beyond a $T$-dependent threshold gate-voltage, we observe maximum hole mobilities approaching 350 cm$^2$/Vs at $T$=300 K. The hole Hall mobility reaches a maximum value of 650 cm$^2$/Vs as $T$ is lowered below $\sim$ 150 K, indicating that insofar WSe$_2$-based field-effect transistors (FETs) display the largest Hall mobilities among the transition metal dichalcogenides. The gate capacitance, as extracted from the Hall-effect, reveals the presence of spurious charges in the channel, while the two-terminal sheet resistivity displays two-dimensional variable-range hopping behavior, indicating carrier localization induced by disorder at the interface between WSe$_2$ and SiO$_2$. We argue that improvements in the fabrication protocols as, for example, the use of a substrate free of dangling bonds are likely to produce WSe$_2$-based FETs displaying higher room temperature mobilities, i.e. approaching those of $p$-doped Si, which would make it a suitable candidate for high performance opto-electronics.
description: 35 pages including supplementary information. 7 figures in main text, 4 figures in supplementary file
Sonnenfleckenzeichnung Nr. 217.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.09.1985, 07:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
(502006) William Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bridging the Silos: A Comparative Analysis of Implementation Science and Improvement Science
Creators: name: Thor, Johan
name: Sevdalis, Nick
name: Andersson-Gäre, Boel
name: Bender, Miriam
name: Nilsen, Per
name: Leeman, Jennifer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Background Implementation science and improvement science have similar goals of improving health care services for better patient and population outcomes, yet historically there has been limited exchange between the two fields. Implementation science was born out of the recognition that research findings and effective practices should be more systematically disseminated and applied in various settings to achieve improved health and welfare of populations. Improvement science has grown out of the wider quality improvement movement, but a fundamental difference between quality improvement and improvement science is that the former generates knowledge for local improvement, whereas the latter is aimed at producing generalizable scientific knowledge. Objectives The first objective of this paper is to characterise and contrast implementation science and improvement science. The second objective, building on the first, is to highlight aspects of improvement science that potentially could inform implementation science and vice versa. Methods We used a critical literature review approach. Search methods included systematic literature searches in PubMed, CINAHL, and PsycINFO until October 2021; reviewing references in identified articles and books; and the authors' own cross-disciplinary knowledge of key literature. Findings The comparative analysis of the fields of implementation science and improvement science centred on six categories: (1) influences; (2) ontology, epistemology and methodology; (3) identified problem; (4) potential solutions; (5) analytical tools; and (6) knowledge production and use. The two fields have different origins and draw mostly on different sources of knowledge, but they have a shared goal of using scientific methods to understand and explain how health care services can be improved for their users. Both describe problems in terms of a gap or chasm between current and optimal care delivery and consider similar strategies to address the problems. Both apply a range of analytical tools to analyse problems and facilitate appropriate solutions. Conclusions Implementation science and improvement science have similar endpoints but different starting points and academic perspectives. To bridge the silos between the fields, increased collaboration between implementation and improvement scholars will help to clarify the differences and connections between the science and practice of improvement, to expand scientific application of quality improvement tools, to further address contextual influences on implementation and improvement efforts, and to share and use theory to support strategy development, delivery and evaluation.
Nanoscale optical positioning of single quantum dots for bright and pure single-photon emission
Creators: name: Sapienza, Luca
name: Davanco, Marcelo
name: Badolato, Antonio
name: Srinivasan, Kartik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Self-assembled, epitaxially-grown InAs/GaAs quantum dots are promising semiconductor quantum emitters that can be integrated on a chip for a variety of photonic quantum information science applications. However, self-assembled growth results in an essentially random in-plane spatial distribution of quantum dots, presenting a challenge in creating devices that exploit the strong interaction of single quantum dots with highly confined optical modes. Here, we present a photoluminescence imaging approach for locating single quantum dots with respect to alignment features with an average position uncertainty < 30 nm (< 10 nm when using a solid immersion lens), which represents an enabling technology for the creation of optimized single quantum dot devices. To that end, we create quantum dot single-photon sources, based on a circular Bragg grating geometry, that simultaneously exhibit high collection efficiency (48 % +/- 5 % into a 0.4 numerical aperture lens, close to the theoretically predicted value of 50 %), low multiphoton probability (g(2)(0) <1 %), and a significant Purcell enhancement factor (~ 3).
(502007) Isabella Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502008) Elizabeth Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sonnenfleckenzeichnung Nr. 256.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.10.1985, 08:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
(502000) Harriot Althea Salt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An analytical study of the vibration-isolation of a reciprocating engine from a rigid foundation
Creators: name: Meng-Koon Lee
Publisher: name: Loughborough University
Year: 2020
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: An analytical study of the vibration-isolation of a reciprocating engine from a rigid foundation
Shrinking Galaxy Disks with Fountain-Driven Accretion from the Halo
Creators: name: Elmegreen, Bruce G.
name: Struck, Curtis
name: Hunter, Deidre A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Star formation in most galaxies requires cosmic gas accretion because the gas consumption time is short compared to the Hubble time. This accretion presumably comes from a combination of infalling satellite debris, cold flows, and condensation of hot halo gas at the cool disk interface, perhaps aided by a galactic fountain. In general, the accretion will have a different specific angular momentum than the part of the disk that receives it, even if the gas comes from the nearby halo. Then the gas disk expands or shrinks over time. Here we show that condensation of halo gas at a rate proportional to the star formation rate in the fountain model will preserve an initial shape, such as an exponential, with a shrinking scale length, leaving behind a stellar disk with a slightly steeper profile of younger stars near the center. This process is slow for most galaxies, producing imperceptible radial speeds, and it may be dominated by other torques, but it could be important for Blue Compact Dwarfs, which tend to have large, irregular gas reservoirs and steep blue profiles in their inner stellar disks.
description: 17 pages with 3 figures, ApJ in press
Sonnenfleckenzeichnung Nr. 270.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.11.1985, 08:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Primary Immune Deficiency: Patients’ Preferences for Replacement Immunoglobulin Therapy
Creators: name: Runken, Michael Chris
name: Ballow, Mark
name: Gonzalez, Juan Marcos
name: Fairchild, Angelyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Purpose Immunoglobulin (Ig) replacement therapy is an important life-saving treatment modality for patients with primary antibody immune deficiency disorders (PAD). IVIG and SCIg are suitable alternatives to treat patients with PAD but vary in key ways. Existing evidence on patient preferences for Ig treatments given the complexities associated with IVIG and SCIg treatment is limited and fails to account for variations in preferences across patients. For this reason, we sought to evaluate PAD patient preferences for features of IVIG and SCIg across different patient characteristics. Materials and Methods 119 PAD patients completed a discrete-choice experiment (DCE) survey. The DCE asked respondents to make choices between carefully constructed treatment alternatives described in terms of generic treatment features. Choices from the DCE were analyzed to determine the relative influence of attribute changes on treatment preferences. We used subgroup analysis to evaluate systematic variations in preferences by patients’ age, gender, time since diagnosis, and treatment experience. Results Patients were primarily concerned about the duration of treatment side effects, but preferences were heterogeneous. This was particularly true around administration features. Time since diagnosis was associated with an increase in patients’ concerns with the number of needles required per infusion. Also, patients appear to prefer the kind of therapy they are currently using which could be the result of properly aligned patient preferences or evidence of patient adaptive behavior. Conclusions Heterogeneity in preferences for Ig replacement treatments suggests that a formal shared decision making process could have an important role in improving patient care.
Self-consistent iteration procedure in analyzing reflectivity and spectroscopic ellipsometry data of multilayered materials and their interfaces
Creators: name: Asmara, Teguh Citra
name: Santoso, Iman
name: Rusydi, Andrivo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: For multilayered materials, reflectivity depends on the complex dielectric function of all the constituent layers, and a detailed analysis is required to separate them. Furthermore, for some cases, new quantum states can occur at the interface which may change the optical properties of the material. In this paper, we discuss various aspects of such analysis, and present a self-consistent iteration procedure, a versatile method to extract and separate the complex dielectric function of each individual layer of a multilayered system. As a case study, we apply this method to LaAlO$_{3}$/SrTiO$_{3}$ heterostructure in which we are able to separate the effects of the interface from the LaAlO$_{3}$ film and the SrTiO$_{3}$ substrate. Our method can be applied to other complex multilayered systems with various numbers of layers.
description: 15 pages, 18 figures. arXiv admin note: text overlap with arXiv:1412.1564
(502002) Adam Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cell reorientation under cyclic stretching
Creators: name: Livne, Ariel
name: Bouchbinder, Eran
name: Geiger, Benjamin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Mechanical cues from the extracellular microenvironment play a central role in regulating the structure, function and fate of living cells. Nevertheless, the precise nature of the mechanisms and processes underlying this crucial cellular mechanosensitivity remains a fundamental open problem. Here we provide a novel framework for addressing cellular sensitivity and response to external forces by experimentally and theoretically studying one of its most striking manifestations -- cell reorientation to a uniform angle in response to cyclic stretching of the underlying substrate. We first show that existing approaches are incompatible with our extensive measurements of cell reorientation. We then propose a fundamentally new theory that shows that dissipative relaxation of the cell's passively-stored, two-dimensional, elastic energy to its minimum actively drives the reorientation process. Our theory is in excellent quantitative agreement with the complete temporal reorientation dynamics of individual cells, measured over a wide range of experimental conditions, thus elucidating a basic aspect of mechanosensitivity.
description: For supplementary materials, see http://www.nature.com/ncomms/2014/140530/ncomms4938/extref/ncomms4938-s1.pdf