Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
Creators: name: Baldelli, Luca
name: Schade, Sebastian
name: Jesús, Silvia
name: Schreglmann, Sebastian R.
name: Sambati, Luisa
name: Gómez-Garre, Pilar
name: Halsband, Claire
name: Calandra-Buonaura, Giovanna
name: Adarmes-Gómez, Astrid Daniela
name: Sixel-Döring, Friederike
name: Zenesini, Corrado
name: Pirazzini, Chiara
name: Garagnani, Paolo
name: Bacalini, Maria Giulia
name: Bhatia, Kailash P.
name: Cortelli, Pietro
name: Mollenhauer, Brit
name: Franceschi, Claudio
name: Mir, Pablo
name: Trenkwalder, Claudia
name: Provini, Federica
name: Houlden, Henry
name: Liò, Pietro
name: Luchinat, Claudio
name: Delledonne, Massimo
name: Mills, Kevin
name: Pedersen, Nancy L.
name: Azevedo, Tiago
name: Bartoletti-Stella, Anna
name: Bonilla-Toribio, Marta
name: Buiza-Rueda, Dolores
name: Capellari, Sabina
name: Carriòn-Claro, Mario
name: Clayton, Robert
name: Dal Molin, Alessandra
name: Dimitri, Giovanna Maria
name: Doykov, Ivan
name: Giuliani, Cristina
name: Hägg, Sara
name: Hällqvist, Jenny
name: Heywood, Wendy
name: Huertas, Ismael
name: Jylhävä, Juulia
name: Labrador-Espinosa, Miguel A.
name: Licari, Cristina
name: Macias, Daniel
name: Magrinelli, Francesca
name: Rodríguez, Juan Francisco Martín
name: Maturo, Maria Giovanna
name: Mengozzi, Giacomo
name: Meoni, Gaia
name: Milazzo, Maddalena
name: Nardini, Christine
name: Periñán-Tocino, Maria Teresa
name: Ravaioli, Francesco
name: Sala, Claudia
name: Spasov, Simeon
name: Tejera-Parrado, Cristina
name: Tenori, Leonardo
name: Paola, Turano
name: Williams, Dylan
name: Xumerle, Luciano
name: Zago, Elisa
name: Broli, Marcella
name: De Massis, Patrizia
name: Escuela-Martin, Rocio
name: Fabbri, Giovanni
name: Gabellini, Anna
name: Guaraldi, Pietro
name: Macrì, Stefania
name: Nassetti, Stefania Alessandra
name: Scaglione, Cesa Lorella Maria
name: Valzania, Franco
name: Rosaria, Cilea
name: Mignani, Francesco
name: Ortega, Rosario Vigo
name: Boninsegna, Claudia
name: De Luca, Silvia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/499
/692/617/375/1718
/692/53/2423
article

description: Abstract: A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort. 340 PD siblings from three sites (Bologna, Seville, Kassel/Goettingen) underwent clinical and neurological evaluations of PD markers. The German part of the cohort was compared with German de novo PD patients (dnPDs) and healthy controls (CTRs) from DeNoPa. Fifteen (4.4%) siblings presented with subtle signs of motor impairment, with MDS-UPDRS-III scores not clinically different from CTRs. Symptoms of orthostatic hypotension were present in 47 siblings (13.8%), no different to CTRs (p = 0.072). No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had &lt;1% probability of having prodromal PD; 100 between 1 and 10%, 26 siblings between 10 and 80%, one fulfilled the criteria for prodromal PD. According to the current analysis, we cannot confirm the increased risk of PD siblings for prodromal PD. Siblings showed a heterogeneous distribution of prodromal PD markers and probability. Additional parameters, including strong disease markers, should be investigated to verify if these results depend on validity and sensitivity of prodromal PD criteria, or if siblings’ risk is not elevated.