Additional file 1 of Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
Creators: name: Garcia, Pedro D. Wendel
name: Aguirre-Bermeo, Hernán
name: Buehler, Philipp K.
name: Alfaro-Farias, Mario
name: Yuen, Bernd
name: David, Sascha
name: Tschoellitsch, Thomas
name: Wengenmayer, Tobias
name: Korsos, Anita
name: Fogagnolo, Alberto
name: Gian-Reto Kleger
name: Wu, Maddalena A.
name: Colombo, Riccardo
name: Turrini, Fabrizio
name: Potalivo, Antonella
name: Rezoagli, Emanuele
name: Rodríguez-García, Raquel
name: Castro, Pedro
name: Lander-Azcona, Arantxa
name: Martín-Delgado, Maria C.
name: Lozano-Gómez, Herminia
name: Ensner, Rolf
name: Michot, Marc P.
name: Gehring, Nadine
name: Schott, Peter
name: Siegemund, Martin
name: Merki, Lukas
name: Wiegand, Jan
name: Jeitziner, Marie M.
name: Laube, Marcus
name: Salomon, Petra
name: Hillgaertner, Frank
name: Dullenkopf, Alexander
name: Ksouri, Hatem
name: Cereghetti, Sara
name: Grazioli, Serge
name: Bürkle, Christian
name: Marrel, Julien
name: Fleisch, Isabelle
name: Marie-Helene Perez
name: Weber, Anja Baltussen
name: Ceruti, Samuele
name: Marquardt, Katharina
name: Hübner, Tobias
name: Redecker, Hermann
name: Studhalter, Michael
name: Stephan, Michael
name: Selz, Daniela
name: Pietsch, Urs
name: Ristic, Anette
name: Heise, Antje
name: Bentrup, Friederike Meyer Zu
name: Laurent, Marilene Franchitti
name: Fodor, Patricia
name: Gaspert, Tomislav
name: Haberthuer, Christoph
name: Colak, Elif
name: Heuberger, Dorothea M.
name: Fumeaux, Thierry
name: Montomoli, Jonathan
name: Guerci, Philippe
name: Schuepbach, Reto A.
name: Hilty, Matthias P.
name: Roche-Campo, Ferran
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences

description: Additional file 1. e-Appendix 1: Specifications on the RISC-19-ICU registry structure and data collection. e-Appendix 2: Missing data handling. e-Table 1: Overall “unmatched” baseline characteristics on Day 0. e-Figure 1: “Love Plot” presenting Standardized Mean Differences between the unmatched and matchedcohort. e-Table 2: Demographics, characteristics at ICU admission, progression of respiratory support and outcome; stratified by survivor status. e-Table 3: Progression of respiratory support stratified by respiratory support strategy at ICU admission. e-Figure 2: Temporal relationship between the period of admission to the intensive care unit and the use of respiratory support strategies or mortality rate. e-Figure 3: Kaplan Meier curves for intensive care unit mortality stratified by the period of admission to the intensive care unit. e-Table 4: Demographics, characteristics at ICU admission, progression of respiratory support and outcome for patients never requiring intubation and invasive mechanical ventilation. e-Figure 4: C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Table 5: Mixed Effect Model of C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Figure 5: Multivariable adjusted COX regression model for the incidence of intubation. e-Figure 6: Multivariable adjusted COX regression model for overall ICU mortality. e-Figure 7: Multivariable adjusted COX regression model for ICU mortality (intubated patients only). e-Figure 8: Multivariable adjusted COX regression model for ICU discharge (intubated patients only). e-Table 6: Prognostic Model for the identification of patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Figure 9: Nomogram, Receiver Operating Curves and stratified Kaplan Meier curve for a prognostic model identifying patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Table 7: Area Under the Receiver Operating Curves (AUROCs) for the Prognostic Score versus classic severity scores.