cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genome engineering in the study of APOBEC3 gene function
Creators: name: Farzan, Raed
Publisher: name: Imperial College London
Year: 2019

description: The “apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like” (APOBEC) gene family defines a set of related Cytidine Deaminases. The best characterised of these are ones that function in the process of mRNA editing. Members of the family are also known to use DNA as their preferred substrate, acting in a consensus sequence, and mediating Cytidine deamination leading to a C to T transition. Recently, this process has been recognised as a major mutational mechanism in several cancer types, where it has been further suggested that members of the APOBEC3 family, and potentially APOBEC3H, that cause this. In order to understand the role of APOBEC3H further, we have used CRISPR-Cas9 gene editing to show that APOBEC3H is a p53 regulated target gene. This has involved making a p53 knockout version of the MCF7 breast cancer cell line, using CRISPR-Cas9 to delete part of the third coding exon of the gene. With this line, it has been possible to confirm that APOBEC3H expression is dependent on p53. In further work, CRISPR-Cas9 was used to make an APOBEC3H knockout in the HCT116 colon cancer line. Having established two independent APOBEC3H knockout lines in HCT116, RNAseq analysis was carried out to compare gene expression of mutant and wild-type cells in both the control and p53 activated setting. Analysis of the RNAseq data has shown that knockout of APOBE3H leads to an attenuated p53 response, suggesting the possibility that APOBEC 3H is co-regulator of p53 regulated gene expression. This is further indicated by the demonstration that over-expression of APOBEC3H in HCT116 wild-type cells enhances the expression of p53 target genes following p53 activation. Taken together, these data identify APOBEC3H as a p53 regulated gene, with a potential role in modulating the p53 response, and potentially identify a new mechanism for APOBEC3H action in cancer.
Summary of Linear Mixed Models from Distinct spinning patterns gain differentiated loading tolerance of silk thread anchorages in spiders with different ecology
Creators: name: Wolff, Jonas O.
name: Meijden, Arie Van Der
name: Herberstein, Marie E.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Building behaviour in animals extends biological functions beyond bodies. Many studies emphasized the role of behavioural programmes, physiology and extrinsic factors for the structure and function of buildings. Structure attachments associated with animal constructions offer yet unrealized research opportunities. Spiders build a variety of one- to three-dimensional structures from silk fibres. The evolution of economic web shapes as a key for ecological success in spiders has been related to the emergence of high performance silks and thread coating glues. However, the role of thread anchorages has been widely neglected in those models. Here, we show that orb-web (Araneidae) and hunting spiders (Sparassidae) use different silk application patterns that determine the structure and robustness of the joint in silk thread anchorages. Silk anchorages of orb-web spiders show a greater robustness against different loading situations, whereas the silk anchorages of hunting spiders have their highest pull-off resistance when loaded parallel to the substrate along the direction of dragline spinning. This suggests that the behavioural ‘printing' of silk into attachment discs along with spinneret morphology was a prerequisite for the evolution of extended silk use in a three-dimensional space. This highlights the ecological role of attachments in the evolution of animal architectures.
title: An Importance-Performance Analysis of Local and Destination Visitors to Monocacy National Battlefield
Creators: name: McCormack, Colin
name: Moser, McKenzie
name: Scruggs, Caleb
name: Zajchowski, Chris
name: Fefer, Jessica
Publisher: name: Old Dominion University Libraries
Year: 2022

description: The purpose of this study was to understand the evolving visitor experience at Monocacy National Battlefield (MONO) in Fredrick, Maryland and, specifically, the way this National Park Service site serves both its’ tourist and local visitors. MONO has two main demographics who utilize it: individuals seeking to learn about historical importance of the site in the Civil War and local recreational visitors from Frederick and surrounding communities. Due to MONO’s proximity to the more densely populated area of Fredrick and Civil War roots, it appeals to both of these populations, who find different uses in the park. Accordingly, we were asked to assist the Park, in better understanding the similarities or differences between visitors desired amenities, opportunities, and experiences at the Park to guide future investment, planning and management. To gauge visitors’ perceived importance and performance across different characteristics, an Importance-Performance questionnaire was developed. This process “provides businesses and organizations with a fairly clear assessment of where they are performing well and where improvements are required” (Draper, 2016; Martilla & James, 1977). Following survey design and approval, onsite sampling occurred over 21 visitor contact days in summer and fall of 2021. 469 visitors were contacted across five sites of interest identified by the park. 445 visitors agreed to participate, yielding an acceptance rate of 94.9 percent. Surveys were conducted online and completed by visitors following their visit. 287 visitors completed more than half of the survey yielding a 61.2 percent response rate. Emerging results suggest key differences and similarities across visitor types.
Methods Supplementary Table from Chronotype variation drives night-time sentinel-like behaviour in hunter-gatherers
Creators: name: Samson, David R.
name: Crittenden, Alyssa N.
name: Mabulla, Ibrahim A.
name: Audax Z. P. Mabulla
name: Nunn, Charles L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Summary statistics for epoch-by-epoch (minute-by-minute) analysis of sleep-wake patterns
Seeing the ocean as the ocean or as the tides – Ācārya dr. Sthaneshwar Timalsina
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2022
Subjects: Shiva
shakta upāya
mahadeva
anava upaya
Durga
amnaya
Divine Mother
Bhairava
agama
Chandi
tripura
timalsina
Shiva Sutra
Devi Mahatmya
Tripurasundari
sarvamnaya-oral-tradition-archive
Tripura Rahasya
shakti
vimarsha-foundation
Mahakali
Sadāśiva
sarvamnaya
krama
Kashmir Shaivism
Abhinavagupta
advaita vedanta
Vasugupta
sthaneshwar timalsina
Kubjika
Camunda
Īśāna
Kaula
Sarvamnaya
Spanda
Guhyakālī
shambhava
consciousness
Saundaryalahari
vedanta
Tantric philosophy
trika
Kali
Shaiva
yantra
tantraloka
Mālinīvijayottaratantra
Tantra
saivadvaita
Kula

description: FREE COURSE offered by Śaivācārya Prof. Sthaneshwar Timalsina: https://www.vimarshafoundation.org/courses

Video source: Vimarsha Foundation's course – Śivajñānabodha – SJB_QA_27_March_2022 – https://www.vimarshafoundation.org/courses

Original YouTube video: https://www.youtube.com/watch?v=lzAodCb_0zI

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
Additional file 1 of Barriers and facilitators to accessing post sexual-based violence health services among young women attending higher education institutions in Nigeria
Creators: name: Ogedegbe, Ajoke Esther
name: Chen, Zhong Eric
name: Adeagbo, Oluwafemi
name: Badru, Oluwaseun
name: Mogo, Ebele R.I.
name: Yankam, Brenda Mbouamba
name: Oreh, Adaeze
name: Gadanya, Muktar A.
name: Bain, Luchuo Engelbert
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
Additional file 1 of Integrated high-throughput small RNA and transcriptome sequencing unveil the shape-dependent toxicity of nano-alumina in rat astrocytes
Creators: name: Chen, Yuanyuan
name: Dong, Li
name: Deng, Fuchang
name: Cao, Yaqiang
name: Fu, Yuanzheng
name: Zhu, Mu
name: Qin, Guangqiu
name: Schultz, Dayna
name: Shekh, Kamran
name: Tang, Song
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer

description: Additional file 1. Additional Tables and figures.
A study on the effects of the CCL5-CCR5 signaling axis on myeloid bias of aged hematopoietic stem cells
Creators: name: Yilmaz, Leyla
name: Weissman, Irving
Publisher: name: Stanford Digital Repository
Year: 2026
Subjects: subject: HSC
subject: Chemokines
subject: Immunology
subject: FOS: Clinical medicine
subject: Aging
subject: Stem cells

description: Hematopoietic stem cells (HSCs) are multipotent self-renewing cells that give rise to all types of blood cells. Past research has identified that long-term hematopoietic stem cells (LT- HSCs) in young mice and humans produce a balanced output of lymphoid and myeloid cells, while in old age they are largely replaced by myeloid biased HSCs (My-HSC). It has not yet been determined whether this transition results from epigenetic changes in a single population of HSC or if two or more subsets of HSCs exist that gain or lose dominance with age via processes of selection. Whether epigenetic change or competition, several characteristics of each may exist to ensure that the appropriate subset is placed in niches that support them. HSC can be mobilized into the blood and home selectively to target tissues. Chemokines are the class of molecules that determine intra- organ migration of HSCs to appropriate niches. Here, we show that the chemokine receptor CCR5 is mainly expressed on My-HSCs, and therefore the frequency of CCR5+ HSCs increases with age. Aged HSCs that do not express CCR5 generate lower frequency of myeloid cells than lymphoid cells upon transplantation into recipients. Additionally, disruption of the CCL5-CCR5 signaling axis with blocking antibodies results in higher frequency of naïve T cells and mature B cells in peripheral blood of aged mice, supporting research that shows the depletion of My-HSCs can result in the rejuvenation of adaptive immunity.
Additional file 2 of Barriers and facilitators to accessing post sexual-based violence health services among young women attending higher education institutions in Nigeria
Creators: name: Ogedegbe, Ajoke Esther
name: Chen, Zhong Eric
name: Adeagbo, Oluwafemi
name: Badru, Oluwaseun
name: Mogo, Ebele R.I.
name: Yankam, Brenda Mbouamba
name: Oreh, Adaeze
name: Gadanya, Muktar A.
name: Bain, Luchuo Engelbert
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 2
title: sainte Cunégonde
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Impératrice, née en 978, épouse d'Henri II de Bavière, fondatrice de la cathédrale de Bamberg ; attributs : insignes impériaux, maquette de la cathédrale de Bamberg, un soc de charrue.
HALQARO MARSHRUTLARDA YUK OQIMLARINI O'Z MUDDATIDA ETKAZIB BERISHNI REJALASHTIRISH
Creators: name: Kuziyev, Abdimurot
name: Maxsumov, Isroiljon
name: Suyunov, Oltibek
Publisher: name: Zenodo
Year: 2024

description: maqolada transport sektori va kommunikatsiyalari rivojlanishi va  muammolari tahlil etilgan. SHuningdek hududdagi yuk oqimlarini o‘z muddatida  avtomobil, temir yo’l va daryo transporti vositalari va tarmog’idan samarali foydalanilgan holda etkazib berish masalasi qaralgan.
Methods Supplementary Materials from Chronotype variation drives night-time sentinel-like behaviour in hunter-gatherers
Creators: name: Samson, David R.
name: Crittenden, Alyssa N.
name: Mabulla, Ibrahim A.
name: Audax Z. P. Mabulla
name: Nunn, Charles L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Sleep Survey
Additional file 1: of Health-related quality of life and its risk factors in Chinese hereditary angioedema patients
Creators: name: Liu, Shuang
name: Wang, Xue
name: Xu, Yingyang
name: Xu, Qun
name: Zhi, Yuxiang
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Table S1. Health-related quality of life in Chinese HAE patients. (DOCX 15 kb)
Artifacts of the Formal Specification and Verification of JDK's Identity Hash Map Implementation
Creators: name: de Boer, Martin
name: de Gow, Stijn
name: Klamroth, Jonas
name: Jung, Christian
name: Ulbrich, Mattias
name: Weigl, Alexander
Publisher: name: Zenodo
Year: 2022

description: This archive contains the artifacts of the paper Formal Specification and Verification of JDK's Identity Hash Map Implementation*
 by Martin de Boer, Stijn de Gouw, Jonas Klamroth, Christian Jung, Mattias Ulbrich and Alexander Weigl accepted as a regular research paper at the 17th International Conference on integrated Formal Methods 2022. Overview. The archive consists of four folders: 01_KEY_IHM -- contains the main artifact of the paper The JML-specified Java class IdentityHashMap (01_KEY_IHM/src/) The KeY proof files which hold the proof tree The used version of KeY Theorem Prover (binaries) and a script to replay the proofs. 02_JJBMC_IHM -- contains the JJBMC setup which shows the found bug (Section 5.1) 03_JUnit_IHM -- contains the JUnit test cases for the `IdentityHashMap` (Section 5.2) 04_KEY_MAPS -- contains the implementation and verification of the different hash map implementations (Section 6.1, Table 2) Please refer to the README.md files in the respective sub-folders for detailed information. License The verification artifacts are licensed under GPL v2. For VerifiedIdentityHashMap and other derivatives of the JDK sources,
 this is a requirement by GPL's copyleft. Please respect the license of the used and bundled tools. We carried them together in the LICENSES/ folder. In short: KeY: GPLv2+ https://key-project.org/ ci-tool: GPLv3 https://github.com/wadoon/key-tools/releases/tag/citool-1.4.0 JJBMC: GPLv2 https://github.com/JonasKlamroth/JJBMC JBMC: 4-clause BSD https://www.cprover.org/jbmc/ Maven: Apache License https://maven.apache.org/
Table S1. Sampling sites and fixation of specimens.; Figure S2. Comparison of conserved protein domains of Ofu-SCO with that of other members of the Thrombospondin-family. from Early evolution of radial glial cells in Bilateria
Creators: name: Helm, Conrad
name: Karl, Anett
name: Beckers, Patrick
name: Kaul-Strehlow, Sabrina
name: Ulbricht, Elke
name: Kourtesis, Ioannis
name: Kuhrt, Heidrun
name: Hausen, Harald
name: Bartolomaeus, Thomas
name: Reichenbach, Andreas
name: Bleidorn, Christoph
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: -; Main domains are named in the scheme. All protein images are generated using SMART [S3, S4], modified and licensed under a Creative Commons Attribution-Share Alike 3.0 Unported (creativecommons.org/licenses/bysa/ 3.0/legalcode).
title: soldat
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Terme d'emploi élargi, désignant tout homme participant à une activité militaire (ou simplement à un combat dès lors que son costume l'identifie comme de guerre).
Supplementary Material for: Antibakterielle In-vitro-Wirksamkeit ätherischer Öle gegen veterinärmedizinisch relevante Keime klinischer Isolate von Hunden, Katzen und Pferden
Creators: name: Bismarck, D.
name: Schneider, M.
name: Müller, E.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Einleitung: Ätherische Öle sind die Grundlage der Aromatherapie. Unter anderem wird ihnen eine antibakterielle Wirkung zugeschrieben. In dieser Studie sollte die In-vitro-Wirksamkeit ätherischer Öle gegen ein breites Spektrum veterinärmedizinisch relevanter Erreger getestet werden. Methoden: Die antibakterielle Aktivität von 16 ätherischen Ölen wurde mittels Agardiffusionstest bestimmt. Getestet wurden grampositive und gramnegative Erreger, die aus klinischen Isolaten von Hunden, Katzen und Pferden aus der veterinärmedizinischen Routinediagnostik stammten. Die Einteilung der Wirksamkeit in nicht, gering-, mittel- und hochgradig wirksam erfolgte anhand der Größe der Hemmhofradien des Bakterienwachstums. Ergebnisse: Generell zeigten sich sowohl grampositive als auch gramnegative Erreger empfindlich gegen einige der getesteten ätherischen Öle. Nicht nur gegen Staphylokokken, sondern auch gegen Methicillin-resistente Stämme der Staphylokokken wiesen die ätherischen Öle in vitro eine nicht zu vernachlässigende Wirkung auf. Pasteurella multocida stellte sich als eher sensibler Keim heraus, während Pseudomonas aeruginosa als vollkommen resistenter Keim eine Ausnahme bildete. Teebaum-, Oregano-, und Bergbohnenkrautöl waren die potentesten Öle. Zusätzlich zeigten sich bei den grampositiven Erregern Lemongrasöl und bei den gramnegativen Erregern Thymianöl als gut wirksam. Schlussfolgerung: Ätherische Öle verfügen in vitro über eine antibakterielle Aktivität gegen klinische Isolate von Hunden, Katzen und Pferden. Diese Studie bietet eine Grundlage für die Anwendung ätherischer Öle in der Veterinärmedizin. Es zeichneten sich Tendenzen im Wirkspektrum einzelner ätherischer Öle bzw. im Grad der Wirksamkeit ätherischer Öle hinsichtlich einzelner Erregerspezies ab, allerdings lässt sich keine sichere Vorhersage über ihre Wirksamkeit gegen einen spezifischen Keim eines individuellen Patienten treffen. Deswegen sollte vor einer Therapie mit ätherischen Ölen deren individuelle Wirksamkeit mittels Aromatogramm getestet werden.
title: saint Vit
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Enfant martyr, mort à Rome en 303 ; représenté sous les traits d'un enfant plongé à mi-corps dans un chaudron de poix bouillante ou portant l'anse d'une petite marmite ; attribut : un coq blanc perché sur un livre.
Is time one-dimensional?
Creators: name: Caruso, Francisco
Publisher: name: arXiv
Year: 2024
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: In the History of Ideas, a succession of philosophical and scientific achievements, concerning the concept of space and its dimensionality, were essential to contribute, after a long period, to the theoretical possibility of thinking physical time with more than one dimension. Meanwhile, such a progress brought with it the expectation that one can either understand the role of dimensionality in the World or disclose how certain physical phenomena depend on it. Some of these issues are sketched throughout the text, as well as those remarkable moments in the History of Science where important contributions were made in order to give a satisfactory answer to the following inescapable question: -- How many dimensions does time have?
description: 22 pp. arXiv admin note: substantial text overlap with arXiv:2101.12167
Supplementary document for A versatile flexible SERS substrate for in situ detection of contaminants in water and fruits based on Ag NPs decorated wrinkled PDMS film - 6433636.pdf
Creators: name: Zhang, Houjia
name: Zhang, Zhaoyi
name: Wang, Hongjun
name: Huang, Lili
name: Yang, Zhenshan
name: Wang, Yangzhi
name: Li, Hefu
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supporting information
Rutgers-Eagleton Poll #167
Creators: name: Eagleton Institute Of Politics, Rutgers University
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Favorable/unfavorable opinion of public figures and groups (3); Governor Christopher Christie proposed state budget (4); Christie budget speech (1); proposed limit to property tax increases (2); government services should be cut less/cut more (7); support/oppose increase to state taxes/fees (5); number of women in high-level political offices (1); support/oppose health care bill (2); most important service provided by local government (1); source of information about local government (1); number of school districts in New Jersey (1); number of municipal governments in NJ (1); consolidation of communities under one local government (5); solve local budget problems (4); NJ as a place to live (1); pride in NJ (1); stay in current neighborhood or move out (1); favorite thing about living in NJ (1).
title:  Intercellular Mitochondrial Transfer Using 3D Bioprinting
Creators: name: Bjerring, Julie
name: Sachs, Patrick C.
name: Bruno, Robert D.
Publisher: name: Old Dominion University Libraries
Year: 2022

description: Mitochondria are one of the most complex and vital organelles in eukaryotic cells. In recent years, it has been shown that through intercellular mitochondrial transfer, this important organelle provides a critical role in tissue homeostasis, damaged tissue repair, and tumor progression under physiological conditions. However, the mechanism of mitochondrial transfer and its effect on various cellular microenvironments has not yet been defined. Understanding the metabolic effects of mitochondrial transfer between cells and exploring the signaling leading to the intercellular mechanisms could provide advancements in both translational medicine and cell therapy for cancer progression and age-related diseases. Our group has studied the ability of the normal mammary microenvironment to redirect cancer cells to a normal mammary epithelial cell fate both in vivo and in vitro using our 3D bioprinting system. Therefore, we sought to determine if mitochondrial transfer may play a role in mammary epithelium induced redirection of cancer cells. We used MCF-7 breast cancer cells and MCF-12a epithelial breast cells for experimentation. Using a fluorescent GFP-MITO lentivirus, we were able to mark mitochondrial protein in the MCF-12a epithelial cells to track mitochondrial transfer activity. The MCF-7 cells were labeled red to distinguish the two cell types. The cells were then co-cultured in 2D tissue flasks and printed into hydrogels using the 3D bioprinter. Using fluorescent microscopy, mitochondrial protein was observed traveling from epithelial to mammary cancer cells. We hypothesize this is done for cancer cells to stabilize mitochondria and improve metabolic function and ATP production. Further research to establish mitochondrial transfer, its mechanism(s), and molecular effects could lead insight into how this cellular communication rescues and normalizes metabolic factors of the mammary and stem cell microenvironment leading to potential fate redirection and cellular revitalization.
AbstractBook_OPTO2017.pdf
Creators: name: Michał Mikołajczyk
Publisher: name: figshare
Year: 2017
Subjects: subject: 20604 Quantum Optics
subject: FOS: Physical sciences
subject: 20503 Nonlinear Optics and Spectroscopy
subject: 30303 Optical Properties of Materials
subject: FOS: Chemical sciences

description: The Book of Abstracts of the OPTO2017 Conference held in Warsaw
Additional file 2: of Health-related quality of life and its risk factors in Chinese hereditary angioedema patients
Creators: name: Liu, Shuang
name: Wang, Xue
name: Xu, Yingyang
name: Xu, Qun
name: Zhi, Yuxiang
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Table S2. Correlation between Clinical Severity Score and HRQoL (Spearman correlation). (DOCX 15 kb)
Additional file 1 of Kastor: a reference-based comparative approach for assessment and correction of gene-fragmenting errors in long-read assemblies of small genomes
Creators: name: Lorv, Janet S.H.
name: McConkey, Brendan J.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Additional file 6 of MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation
Creators: name: Zhang, Ting
name: Zhang, Yanan
name: Liu, Jie
name: Ma, Yan
name: Ye, Qinong
name: Yan, Xinlong
name: Ding, Lihua
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 6:. Table S1 Primes sequence for shRNA, miRNA mimics, probe and qRT-PCR
title: Role of Socioeconomic Status and Obesity in African American Adults
Creators: name: Bryant, Alexis
name: Christian, Laura
name: Mcleod, Naomi
Publisher: name: Old Dominion University Libraries
Year: 2022

description: African Americans have a higher prevalence of obesity compared to any other racial/ethnic group due to a variety of factors, including socioeconomic status. This research paper presents a semi-systematic literature review revealing the impact socioeconomic status has on obesity among African American adults in the United States. In order to gain a comprehensive understanding of this public health issue, we examined the risk factors, risk behaviors, and health outcomes surrounding obesity among this population. An informational web-based search was conducted using various research databases including PubMed, CINAHL, and EBSCOHost. The terms “obesity,” “African Americans, “ and “socioeconomic status” were utilized as common keywords, along with other MeSH terms. The overall pattern of results display a positive association between socioeconomic status and obesity among African Americans in the United States. Findings indicate that certain health behaviors such as unhealthy eating, physical inactivity, and lack of sleep can increase the chances of an individual becoming obese. Not only does indulging in these harmful activities pose an increased risk, but other health outcomes may arise as a result of being obese such as a reduced life expectancy and a variety of chronic conditions. It is essential that further examination is completed to serve as a foundation for creating preventative strategies for this population. Researchers can utilize the findings provided from this literature review to help decrease the obesity rates among African American adults in the United States.
title: Neonatal Abstinence Syndrome in Virginia: Supporting Pregnant Women Impacted by Opioid and Other Substance Use
Creators: name: Burns, Anna
Publisher: name: Old Dominion University Libraries
Year: 2022

description: Neonatal Abstinence Syndrome (NAS) is a preventable condition that newborn children may experience as a result of in utero exposure to certain toxic substances such as opioids, alcohol, sedatives, and barbiturates. The syndrome develops in approximately 55-99 percent of children who are exposed to these substances. Symptoms of NAS may include respiratory distress, irritability, difficulty feeding, and seizures. Research indicates that mothers who receive treatment and support during pregnancy have a better prognosis for recovery from addiction, which improves neonate outcomes. Virginia Department of Health (VDH) is currently working on improving their NAS Surveillance System. The surveillance system helps to estimate the number of children born with NAS in Virginia and to identify high risk mothers and children who may benefit from local services and resources. Up to date, there is no state-level interventions for NAS prevention exists in Virginia. The overall goals of this project are to (1) conduct a comprehensive NAS needs assessment by conducting a literature review and using exiting department data and (2) to plan a public health intervention that would address NAS prevention needs among at risk pregnant women who live in Virginia.
Supplementary Material for: A Clinical Score for Predicting Atrial Fibrillation in Patients with Cryptogenic Stroke or Transient Ischemic Attack
Creators: name: Kwong, C.
name: Ling, A.Y.
name: Crawford, M.H.
name: Zhao, S.X.
name: Shah, N.H.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Objectives: Detection of atrial fibrillation (AF) in post-cryptogenic stroke (CS) or transient ischemic attack (TIA) patients carries important therapeutic implications. Methods: To risk stratify CS/TIA patients for later development of AF, we conducted a retrospective cohort study using data from 1995 to 2015 in the Stanford Translational Research Integrated Database Environment (STRIDE). Results: Of the 9,589 adult patients (age ≥40 years) with CS/TIA included, 482 (5%) patients developed AF post CS/TIA. Of those patients, 28.4, 26.3, and 45.3% were diagnosed with AF 1-12 months, 1-3 years, and >3 years after the index CS/TIA, respectively. Age (≥75 years), obesity, congestive heart failure, hypertension, coronary artery disease, peripheral vascular disease, and valve disease are significant risk factors, with the following respective odds ratios (95% CI): 1.73 (1.39-2.16), 1.53 (1.05-2.18), 3.34 (2.61-4.28), 2.01 (1.53-2.68), 1.72 (1.35-2.19), 1.37 (1.02-1.84), and 2.05 (1.55-2.69). A risk-scoring system, i.e., the HAVOC score, was constructed using these 7 clinical variables that successfully stratify patients into 3 risk groups, with good model discrimination (area under the curve = 0.77). Conclusions: Findings from this study support the strategy of looking longer and harder for AF in post-CS/TIA patients. The HAVOC score identifies different levels of AF risk and may be used to select patients for extended rhythm monitoring.
Additional file 1 of Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic responses in ovarian cancer
Creators: name: Feng, Songwei
name: Yin, Han
name: Zhang, Ke
name: Shan, Mei
name: Ji, Xuan
name: Luo, Shanhui
name: Shen, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. Table S1. A list of FIRGs
Supplementary Methods from Stress hormones predict a host superspreader phenotype in the West Nile virus system
Creators: name: Gervasi, Stephanie S.
name: Burgan, Sarah C.
name: Hofmeister, Erik
name: Unnasch, Thomas R.
name: Martin, Lynn B.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplementary Methods Sections
Additional file 2 of Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic responses in ovarian cancer
Creators: name: Feng, Songwei
name: Yin, Han
name: Zhang, Ke
name: Shan, Mei
name: Ji, Xuan
name: Luo, Shanhui
name: Shen, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified

description: Additional file 2. Figure S1. Calibration curve of nomogram. (a-b) Calibration curve of nomogram based on FIRLs signature for OS prediction at 1 year (a), 3 year (b) , and 5 year (c) in the training set; (d-f) Calibration curve of nomogram based on FIRLs signature for OS prediction at 1 year (d), 3 year (e), and 5 year (f) in the testing set.
Chemostratigraphic data from A cosmopolitan Late Ediacaran (ca 550–541 Ma) biotic assemblage: new fossils from Nevada and Namibia support a global biostratigraphic link
Creators: name: E. F. Smith
name: L. L. Nelson
name: S. M. Tweedt
name: H. Zeng
name: J. B. Workman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Carbon (δ13C) and oxygen (δ18O) isotopic methods and measurements
title: Workplace Health and Wellness Program: Enhancing Employee Morale via Incentives, Gym Memberships, and Fitness Trackers: A Secondary Review
Creators: name: Carretta, Rikki
Publisher: name: Old Dominion University Libraries
Year: 2022

description: This secondary review focuses on employer-funded wellness programs consisting of gym memberships, fitness trackers, and incentives to increase employee mental and physical health in and outside of the workplace.

Purpose: Analyze existing peer-reviewed literature to determine if employer-provided gym memberships, fitness trackers, and incentivization programs enhance employee morale.

Methods: The target population of this literature review is employees within the U.S. workforce. The researcher included articles from January 2016 to February 2021 from ScienceDirect, PubMed, and PsycINFO databases. The author included 13 of the 571 articles after applying the keywords and reviewing the title, abstract, and content. The author analyzed the Precede-Proceed model and the Health Impact in 5 Model. The inclusion criteria included workplace health programs, gym memberships, fitness trackers, or gamification, and individuals 18 years or older. The exclusion criteria included sitting interventions, lack of rewards or incentives, and not providing gym memberships or fitness trackers.

Findings: The researcher found increased employee morale when providing gym memberships, fitness trackers, and incentive programs. However, the most successful programs were a combination of the three.

Conclusions: The author concluded that all workplaces should implement wellness programs, especially those with significant sedentary time. Moreover, the researcher found a positive correlation among employers providing employees with gym memberships, fitness trackers, and incentive programs.

Recommendations: Future research needs to evaluate the effectiveness of inclusive wellness programs providing gym memberships, fitness trackers, and incentives.
Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study
Creators: name: R Kurzrock
name: DW Bowles
name: H Kang
name: F Meric-Bernstam
name: J Hainsworth
name: DR Spigel
name: R Bose
name: H Burris
name: CJ Sweeney
name: MS Beattie
name: S Blotner
name: K Schulze
name: V Cuchelkar
name: C Swanton
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Tumour Biology
Signalling & Oncogenes
Genetics & Genomics
Genome Integrity & Repair
Human Biology & Physiology
Chemical Biology & High Throughput
Ecology,Evolution & Ethology
Computational & Systems Biology

description: BACKGROUND: Systemic therapy options for salivary cancers are limited. MyPathway (NCT02091141), a phase IIa study, evaluates targeted therapies in non-indicated tumor types with actionable molecular alterations. Here, we present the efficacy and safety results for a subgroup of MyPathway patients with advanced salivary gland cancer (SGC) matched to targeted therapies based on tumor molecular characteristics. PATIENTS AND METHODS: MyPathway is an ongoing, multiple basket, open-label, non-randomized, multi-center study. Patients with advanced SGC received pertuzumab + trastuzumab (HER2 alteration), vismodegib (PTCH-1/SMO mutation), vemurafenib (BRAF V600 mutation), or atezolizumab [high tumor mutational burden (TMB)]. The primary endpoint is the objective response rate (ORR). RESULTS: As of January 15, 2018, 19 patients with SGC were enrolled and treated in MyPathway (15 with HER2 amplification and/or overexpression and one each with a HER2 mutation without amplification or overexpression, PTCH-1 mutation, BRAF mutation, and high TMB). In the 15 patients with HER2 amplification/overexpression (with or without mutations) who were treated with pertuzumab + trastuzumab, 9 had an objective response (1 complete response, 8 partial responses) for an ORR of 60% (9.2 months median response duration). The clinical benefit rate (defined by patients with objective responses or stable disease >4 months) was 67% (10/15), median progression-free survival (PFS) was 8.6 months, and median overall survival was 20.4 months. Stable disease was observed in the patient with a HER2 mutation (pertuzumab + trastuzumab, n = 1/1, PFS 11.0 months), and partial responses in patients with the PTCH-1 mutation (vismodegib, n = 1/1, PFS 14.3 months), BRAF mutation (vemurafenib, n = 1/1, PFS 18.5 months), and high TMB (atezolizumab, n = 1/1, PFS 5.5+ months). No unexpected toxicity occurred. CONCLUSIONS: Overall, 12 of 19 patients (63%) with advanced SGC, treated with chemotherapy-free regimens matched to specific molecular alterations, experienced an objective response. Data from MyPathway suggest that matched targeted therapy for SGC has promising efficacy, supporting molecular profiling in treatment determination.
Supplementary Figures from Stress hormones predict a host superspreader phenotype in the West Nile virus system
Creators: name: Gervasi, Stephanie S.
name: Burgan, Sarah C.
name: Hofmeister, Erik
name: Unnasch, Thomas R.
name: Martin, Lynn B.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplementary Figures
Additional file 1 of Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo
Creators: name: Yang, Yin
name: Ondrejcak, Tomas
name: Hu, Neng-Wei
name: Klyubin, Igor
name: Rowan, Michael J.
Publisher: name: figshare
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine

description: Additonal file 1
Additional photos of Ediacaran biota from A cosmopolitan Late Ediacaran (ca 550–541 Ma) biotic assemblage: new fossils from Nevada and Namibia support a global biostratigraphic link
Creators: name: E. F. Smith
name: L. L. Nelson
name: S. M. Tweedt
name: H. Zeng
name: J. B. Workman
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Additional photos of Ediacaran body fossils from the lower member of the Wood Canyon Formation in the Montgomery Mountains, Nevada
Additional file 1 of Prescription patterns of comedications associated with drug-drug interactions risk in HCV-infected patients undergoing direct-acting antiviral treatment: an analysis of an administrative claims database in Japan
Creators: name: Nakamoto, Daisuke
name: Piao, Yi
name: Mizutani, Hajime
name: Wakabayashi, Ryozo
name: Otokita, Satoshi
name: Stead, Alice
name: Hernandez, Candido
name: Jinushi, Masahisa
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
Additional file 1 of Strainline: full-length de novo viral haplotype reconstruction from noisy long reads
Creators: name: Luo, Xiao
name: Kang, Xiongbin
name: Schönhuth, Alexander
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 1 Supplement: This contains all supplementary materials referenced in the main text.
title: Factors Predicting Intention to Initiate Mental Health Services among College Students Returning to Campus during COVID-19
Creators: name: Dumadag, Anne
name: Tonn, Cara
name: Galadima, Hadiza
Publisher: name: Old Dominion University Libraries
Year: 2022

description: Introduction: While the impact of transitioning to a virtual learning environment during the COVID-19 pandemic is well-documented, few studies have explored the mental health impact of reopening campus. As a measurement of mental health impact within the context of reopening campus, this study aims to identify factors associated with intention to initiate mental health services (MHS), with a particular focus on race, among college students.

Methods: A cross-sectional survey using stratified sampling was conducted via Qualtrics among students at a Virginia university in January 2022. The survey assessed demographics, online class experiences, past and future use of MHS, and feelings towards campus reopening. Crude and adjusted logistic regression models were developed to examine the association between race and intention to initiate MHS, controlling for other demographics.

Results: Of the 236 students who completed the survey, 39.4% (n= 93) reported they intended to initiate MHS within the next one to six months. Controlling for other demographics, intention to initiate MHS did not vary significantly by race; however, trends suggested that African Americans and those of two or more races were more likely to report intention to initiate MHS than Asians. Analyses indicated that age, gender, and employment status were significantly associated with intention to initiate MHS (p<0.05).

Conclusion: Campus reopening has presented unique challenges to students as they adjust to a “new normal.” Given the small sample size in the current study, future research is needed to further understand how utilization of MHS differs by race and other demographic characteristics.
The South Carolina Healthy Communities Index: Visualizing Health Inequality Using Interactive Maps and Dashboards
Creators: name: Borders, Stephen
Publisher: name: figshare
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: This project contains a series of documents and data files related to a lesson plan designed for ArcGIS Online. This lesson is centered on health disparities in the context of race and ethnicity. We begin by creating a community health index using publicly available data from the Centers for Disease and Prevention (CDC) as a data reduction technique to facilitate easier and more effective comparisons across geographies and communities. The index provides students and the users of analysis with a consolidated view of how communities are fairing with regard to their overall community health. We then add race and ethnicity data to the model to help bring greater context and understanding of health disparities in South Carolina. The lesson concludes with the creation of an interactive dashboard that allows students and users to better understand the issues that matter to health disparities, allowing them to participate in the analytics process by visualizing key trends and occurrences. These same concepts and processes could be used to explore other important topics regarding inequality, such as housing, education, and wealth.
Links to video demonstrations for each step or module can be found in a PDF entitled: South Carolina Healthy Communities Index - FigShare Overview. You can also find a link to the model dashboard in this document.

There are also several associated files (e.g. Data Dictionary and manipulated data from the American Community Survey) posted with the lesson.
Feel free to contact me with questions or comments.
Updated: April 5th - 2022
The South Carolina Healthy Communities Index: Visualizing Health Inequality Using Interactive Maps and Dashboards
Creators: name: Borders, Stephen
Publisher: name: figshare
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: This project contains a series of documents and data files related to a lesson plan designed for ArcGIS Online. This lesson is centered on health disparities in the context of race and ethnicity. We begin by creating a community health index using publicly available data from the Centers for Disease and Prevention (CDC) as a data reduction technique to facilitate easier and more effective comparisons across geographies and communities. The index provides students and the users of analysis with a consolidated view of how communities are fairing with regard to their overall community health. We then add race and ethnicity data to the model to help bring greater context and understanding of health disparities in South Carolina. The lesson concludes with the creation of an interactive dashboard that allows students and users to better understand the issues that matter to health disparities, allowing them to participate in the analytics process by visualizing key trends and occurrences. These same concepts and processes could be used to explore other important topics regarding inequality, such as housing, education, and wealth.
Links to video demonstrations for each step or module can be found in a PDF entitled: South Carolina Healthy Communities Index - FigShare Overview. You can also find a link to the model dashboard in this document.

There are also several associated files (e.g. Data Dictionary and manipulated data from the American Community Survey) posted with the lesson.
Feel free to contact me with questions or comments.
Supplemental Table from Stacked Bt maize and arthropod predators: exposure to insecticidal Cry proteins and potential hazards
Creators: name: Zdeňka Svobodová
name: Yinghua Shu
name: Habuštová, Oxana Skoková
name: Romeis, Jörg
name: Meissle, Michael
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Statistical analyses of life table parameters of lacewing larvae (Chrysoperla carnea), ladybeetle larvae (Harmonia axyridis), and juvenile spiders (Phylloneta impressa) in bi- and tritrophic feeding experiments