cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis
Creators: name: Baur, Rachel
name: Kashon, Michael
name: Lukomska, Ewa
name: Weatherly, Lisa M.
name: Shane, Hillary L.
name: Anderson, Stacey E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Triclosan is an anti-microbial chemical incorporated into products that are applied to the skin of healthcare workers. Exposure to triclosan has previously been shown to be associated with allergic disease in humans and impact the immune responses in animal models. Additionally, studies have shown that exposure to triclosan dermally activates the NLRP3 inflammasome and disrupts the skin barrier integrity in mice. The skin is the largest organ of the body and plays an important role as a physical barrier and regulator of the immune system. Alterations in the barrier and immune regulatory functions of the skin have been demonstrated to increase the risk of sensitization and development of allergic disease. In this study, the impact of triclosan exposure on the skin barrier and keratinocyte function was investigated using a model of reconstructed human epidermis. The apical surface of reconstructed human epidermis was exposed to triclosan (0.05–0.2%) once for 6, 24, or 48 h or daily for 5 consecutive days. Exposure to triclosan increased epidermal permeability and altered the expression of genes involved in formation of the skin barrier. Additionally, exposure to triclosan altered the expression patterns of several cytokines and growth factors. Together, these results suggest that exposure to triclosan impacts skin barrier integrity and function of human keratinocytes and suggests that these alterations may impact immune regulation.
Uniform cortical stimulation in the early visual cortex evokes modular patterned activity through intracortical network interactions
Creators: name: Mulholland, Haleigh N.
name: Kaschube, Matthias
name: Smith, Gordon B.
Publisher: name: G-Node
Year: 2021
Subjects: Computational Neuroscience
Sensory processing and perception

description: Bernstein Conference 2021 abstract. http://bernstein-conference.de
title: Acute Diverticulitis - CRP can safely guide the utilisation of high quality CT imaging
Creators: name: Anderson, David
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Inflammation
subject: Diverticula
subject: Abscess
subject: Drainage
subject: CT
subject: Gastrointestinal tract

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Acute diverticulitis is the commonest emergency admission to the Lothian Colorectal Unit, the largest colorectal unit in the UK. The incidence of complicated diverticular disease, associated with abscess and/or perforation is increasing...
In-silico and in-vitro identification of triazole based compounds as potential EGFR inhibitors targeting lung cancer
Creators: name: Kumar, Sunil
name: Shukla, Monu Kumar
name: Ali, Iqra
name: Abbas, Faheem
name: Verma, Rachna
name: Chandra, Girish
name: Kumar, Deepak
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The use of FDA-approved drugs for the therapy of lung cancer through drug repurposing is a noteworthy approach. We retrieved all the FDA-approved triazole-based drugs from Drugbank and conducted docking-based virtual screening of the triazole-based FDA-approved drugs against the EGFR target. Deferasirox demonstrated hydrogen bonding interactions with residues Thr 830, Asp 831, Lys 721 and Met 769 of the EGFR-TKD receptor (PDB ID: 1M17) and Posaconazole showed hydrogen bonding with residues Met 769 and Glu 734 of the similar EGFR receptor along with the binding energies of −9.60, −9.50, kcal/mol respectively. The dock score for reference molecule found to be −6.70 (kcal/mol). Best two ligands (Deferasirox and Posaconazole) were selected on the basis of dock score from the virtual screening results for in vitro NRU assay using A549 cells to determine their cytotoxicity and cell viability. During the in vitro NRU experiment, Deferasirox and Posaconazole demonstrated IC50 values of 114.9 and 910.2 µM, respectively. MD simulations were performed to investigate the dynamic behaviour and stability, and interactions were compared to the standard inhibitor for the EGFR target. DFT studies were carried out to determine their molecular properties, including their electronic structure, bond lengths and bond energies. The results of the in silico and in vitro studies were analysed to assess the potential of Deferasirox and Posaconazole for use as anticancer agents in the mitigation of lung cancer symptoms. This study focused on repurposing FDA-approved triazole-based compounds to identify their potential as effective lung cancer treatments with anticancer properties.
title: Hypertrophic olivary degeneration as additional finding in patients with certain pathological conditions in brain stem and cerebellum.
Creators: name: Skorokhoda, Anna
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Diagnostic procedure
subject: MR
subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To present, share and describe our experience in MRI cases of certain pathological conditions in brain stem and cerebellum, where we pointed attention to additional finding of focal hyperintensity changes in medulla oblongata olive on T2 weighted...
title: Graphical synoptic template reporting for perianal fistulae on MRI.
Creators: name: Dang, Hung
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Diagnostic procedure
subject: MR
subject: Gastrointestinal tract
subject: Abdomen
subject: Fistula

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review of the relevant anatomy associated with perianal fistula. Understanding the importance of MRI in pre-operative planning, key imaging features and their clinical significance. Implementation of a standardised structured graphical synoptic...
title: Molecular Magnetic resonance (mMRI) imaging: a review of currently available research imaging techniques and clinical applications
Creators: name: Crilly, Shane
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Molecular imaging
subject: MR physics
subject: Hybrid Imaging
subject: MR
subject: MR-Spectroscopy
subject: Image manipulation / Reconstruction
subject: Molecular imaging
subject: Physics
subject: Technical aspects
subject: Molecular, genomics and proteomics
subject: Education and training
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Purpose Molecular MRI (mMRI) is an application of molecular imaging which allows in vivo visualisation of biological/ molecular events. Molecular MRI in basic terms involves contrast media modification of tissue specific MRI relaxation times which...
“Frate sole” e il fotovoltaico. Il ruolo della parrocchia e la tutela dell’ambiente tra normativa statale e Magistero della Chiesa cattolica
Creators: name: Tavani, Angela Patrizia
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: Enti ecclesiastici

description: SOMMARIO: 1. Premessa – 2. L’ente religioso imprenditore – 3. Rinnovata centralità di “frate sole” nel III millennio: le parrocchie e il fotovoltaico – 4. Il Magistero della Chiesa cattolica in tema di salvaguardia dell’ambiente – 5. Considerazioni conclusive.

ABSTRACT: The establishment of a social enterprise for the production and sale of electricity through the creation of a photovoltaic system by imposing some parishes of Mantua shows that there is no conflict between the specific nature of ecclesiastical entity and the exercise by this socially useful economic activity, because the economic activity in order to provide the capital resources required to achieve the purpose of religion or belief, does not change the nature of ecclesiastical entity, because it does not absorb or blur the religious or of worship but rather reinforces the essence, as related and instrumental to this The invitation to promote renewable energy to protect the environment, has been the subject of interventions at various levels by both the Italian state and by the European Community, also Magisterium of the Catholic Church has often called for a real ecological conversion and an ecumenical commitment to that effect Associated Parishes are an example of civil economy, characterized by human sociality and reciprocity, as opposed to a utilitarian vision of the market based on the logic of exchange of equivalents.
description: Stato, Chiese e pluralismo confessionale, 2011: 21 novembre
title: German and Euro Area Economies Will Benefit from a U.S. Interest Rate Hike in the Short Term
Creators: name: Hanisch, Max
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: C32 Multiple or Simultaneous Equation Models: Time-Series Models; Dynamic Quantile Regressions; Dynamic Treatment Effect Models
subject: E52 Monetary Policy
subject: E58 Central Banks and Their Policies
subject: Spillover
subject: U.S. monetary policy
subject: Eurozone

description: To accompany the economic upturn in the U.S., the Federal Reserve Bank has been raising its benchmark interest rate incrementally. In an increasingly globalized world in which the American economy plays a key role, an action like this has spillover effects on the international level. Based on a dynamic factor model, the present study shows that the member states of the euro area—Germany in particular—can temporarily benefit from a restrictive U.S. monetary policy. The devaluation of the euro against the U.S. dollar will improve the euro area’s balance of trade and trigger an economic upturn, primarily in the member states in which the U.S. has captured a substantial portion of exports.
description: DIW Weekly Report, 8 (2018), 12, S. 115-121
title: Monitoring tidal hydrology within saltmarsh vegetation to detect current attenuation using the Mini Buoy
Creators: name: Merz, Nina
Publisher: name: University of Glasgow
Year: 2025

description: Coastal zones are associated with growing populations, and with climate change increasing intensity and frequency of storms these communities are increasingly facing the threat of flooding. Saltmarshes are coastal ecosystems which are known to attenuate hydrodynamic energy thereby reducing risk for coastal populations. The incorporation of saltmarshes into coastal defence strategies is hindered by gaps in our knowledge concerning lateral saltmarsh dynamics and biophysical feedback networks. This knowledge is essential for accurately and reliably predicting the risk reduction capacity of nature-based solutions for flooding. Developing a tool for long-term hydrodynamic monitoring, quantifying the current velocity (Cv) attenuation effects of salt marsh vegetation, and understanding how plant traits can impact the Cv attenuation capacity of saltmarsh species are critical steps towards better understanding saltmarsh dynamics.

In this study, we quantified the Cv attenuation of two salt marsh species (Bolboschoenus maritimus and Phragmites australis) that are abundant in the Inner Clyde Estuary. Using a novel low-cost method (the Mini-Buoy), we monitored hydrodynamics at the edge and five meters into the vegetation at three monospecific stands of each species. Two models of the Mini Buoy (the Pendant and the B4+) were compared against each other to determine which was better suited for deployment within saltmarsh vegetation and for quantifying current attenuation. Vegetation surveys at the start, middle, and end of the growing season (May-Sep) were carried out to associate plant traits with their attenuation effect. This study found that the Pendant Mini Buoy was the better model for hydrodynamic monitoring within the vegetation canopy and for quantification of current attenuation in shallow, low-energy conditions. Also, morphological adaptations to the physical environment were observed in both B. maritimus and P. australis where slenderness of the plants increased landward of the wave-exposed seaward boundary. Between the two species, significant differences in morphology and attenuation capacity were observed. Lower stem density and FSA was consistently observed in P. australis which was also found to develop in lower hydrodynamic energy areas, suggesting that P. australis is more vulnerable to hydrodynamic forcing. Overall, B. maritimus (maximum Cv reduction of ~60%) was found to be more effective at reducing current velocities than P.australis (maximum Cv reduction of ~40%).
A mechanistic theory of contextual modulations of cortical processing.
Creators: name: Papadopoulos, Lia
name: Wyrick, David
name: Wehr, Michael
name: Mazzucato, Luca
Publisher: name: G-Node
Year: 2021
Subjects: Computational Neuroscience
Sensory processing and perception

description: Bernstein Conference 2021 abstract. http://bernstein-conference.de
La Chiesa tra politica e religiosità popolare nei primi decenni del XX secolo. Alcune suggestioni
Creators: name: Bilotti, Domenico
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: Diritti delle religioni

description: Il contributo è stato sottoposto alla valutazione del Prof. Antonino Mantineo, che ne ha attestato la scientificità e l’originalità.

SOMMARIO: 1. Apparente desuetudine dell’analisi - 2. La Prima Guerra Mondiale e le sue conseguenze nella società italiana. Questioni irrisolte – 3. Il contributo cattolico prima e dopo il Fascismo. Alcune ipotesi di continuità?
description: Stato, Chiese e pluralismo confessionale, 2011: 28 novembre
title: New Government’s Policies Give the Thriving German Economy an Additional Boost
Creators: name: Fichtner, Ferdinand
name: Brenke, Karl
name: Breuer, Christian
name: Clemens, Marius
name: Junker, Simon
name: Michelsen, Claus
name: Schlaak, Thore
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: E32 Business Fluctuations; Cycles
subject: E66 General Outlook and Conditions
subject: F01 Global Outlook
subject: Business cycle forecast
subject: economic outlook

description: The German economy will grow by 2.4 percent this year, especially due to strong foreign demand. Brisk investment activity continues in this economic climate; stimulus from foreign trade, however, is weakening somewhat. Despite strong consumer demand in the coming quarters, employment and economic output growth are losing momentum. However, stimulus measures from the new federal government will increase income and thus private households’ consumption. With 1.9 percent growth in 2019, overall economic capacity will remain well utilized.
description: DIW Weekly Report, 8 (2018), 10/11, S. 102-105
title: The Global Economy and the Euro Area: Expansion Continues but Is Losing Momentum
Creators: name: Fichtner, Ferdinand
name: Baldi, Guido
name: Dany-Knedlik, Geraldine
name: Engerer, Hella
name: Gebauer, Stefan
name: Rieth, Malte
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: E32 Business Fluctuations; Cycles
subject: E66 General Outlook and Conditions
subject: F01 Global Outlook
subject: Business cycle forecast
subject: economic outlook

description: The global economy is likely to grow by over four percent this year and somewhat less next year. DIW Berlin has slightly raised its forecast for both years. Developed economies as well as emerging markets are experiencing an upturn; however, growth rates are likely to be slightly lower in the future. One reason for the sound global economy is the fact that the labor market situation is steadily improving, leading to an increase in private consumption. Along with fiscal stimuli in the form of tax cuts and government spending programs, more private consumption is also likely to trigger corporate investment activities. Monetary policy remains expansionary, but gradual increases in interest rates in major economies as well as the European Central Bank's (ECB) phasing-out of government bond purchases may somewhat curb growth in the U.S. and the euro area. This would also weaken the expansion in emerging economies. Risks to global growth stem from protectionist activities in the United States as well as political uncertainty in Europe.
description: DIW Weekly Report, 8 (2018), 10/11, S. 98-100
title: New Government Prolongs German Economic Upswing: Editorial
Creators: name: Fichtner, Ferdinand
name: Baldi, Guido
name: Brenke, Karl
name: Breuer, Christian
name: Clemens, Marius
name: Dany-Knedlik, Geraldine
name: Engerer, Hella
name: Fratzscher, Marcel
name: Gebauer, Stefan
name: Junker, Simon
name: Michelsen, Claus
name: Rieth, Malte
name: Schlaak, Thore
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018

description: DIW Weekly Report, 8 (2018), 10/11, S. 95-97
title: German Right-Wing Party AfD Finds More Support in Rural Areas with Aging Populations
Creators: name: Franz, Christian
name: Fratzscher, Marcel
name: Kritikos, Alexander S.
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: D72 Political Processes: Rent-seeking, Lobbying, Elections, Legislatures, and Voting Behavior
subject: Z13 Economic Sociology; Economic Anthropology; Social and Economic Stratification
subject: German political parties
subject: federal elections 2017
subject: structural data

description: This study examines in which setting the German political party Alternative for Germany (Alternative für Deutschland, AfD) performed well in the 2017 parliamentary elections. The AfD’s popularity was relatively high in electoral districts with an above-average amount of craft businesses, a disproportionately high amount of older residents and workers in the manufacturing sector, and—applicable mainly to western German electoral districts—where the disposable household income was lower than the national average. The unemployment rate in the electoral districts and the share of foreigners in the population affect the AfD’s popularity to a lesser extent. Generally, the AfD performs better in rural areas with negative demographic trends—a phenomenon that occurs more frequently in eastern German districts than in western districts. This allows for the conclusion that perspective is lacking among those living in rural areas with negative demographic developments.
description: DIW Weekly Report, 8 (2018), 7/8, S. 69-79
title: Characterising reported MRI brain incidental findings
Creators: name: White, Gregory
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: CNS
subject: MR
subject: Normal variants
subject: Screening
subject: Neoplasia
subject: Artifacts
subject: Epidemiology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Incidental MRI brain findings present a clinical problem because they are becoming more common with availability of diagnostic imaging and improvements in imaging technology e.g. 3T MRI. It is often difficult to determine their clinical...
A developmental model for the emergence of an orientation preference map in the mouse superior colliculus
Creators: name: Teh, Kai Lun
name: Sibille, Jérémie
name: Kremkow, Jens
Publisher: name: G-Node
Year: 2021
Subjects: Computational Neuroscience
Sensory processing and perception

description: Bernstein Conference 2021 abstract. http://bernstein-conference.de
La partecipazione dei fedeli laici alla vita pubblica. Testimonianza cristiana, etica pubblica e bene comune nell’insegnamento di Benedetto XVI
Creators: name: Franceschi, Fabio
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: Diritti delle religioni

description: Versione riveduta e ampliata, nel testo e nell’apparato bibliografico, della relazione presentata con il titolo “L’impegno dei fedeli laici nella vita pubblica tra responsabilità propria, libertà e dovere di obbedienza al magistero. L’insegnamento di Benedetto XVI” al Convegno di studi “Il fedele laico: realtà e prospettive”, organizzato dalla Pontificia Università della Santa Croce (7-8 aprile 2011). Il contributo è destinato alla pubblicazione negli Atti del Convegno.

SOMMARIO: 1. Considerazioni introduttive. Natura essenzialmente laicale della responsabilità politica - 2. L’intervento della Chiesa nel dibattito pubblico su questioni inerenti alla vita sociale e politica. I principi c.d. non negoziabili - 3. Fondamentale libertà dei fedeli rispetto alle indicazioni della gerarchia in materia temporale – 4. La funzione di orientamento dei pastori della comunità ecclesiale e i confini dell’intervento della stessa – 5. I limiti alla libertà dei fedeli in materia temporale: il rapporto tra libertà e verità e la salvaguardia delle esigenze etiche fondamentali e irrinunciabili per il bene comune e della società – 6. Benedetto XVI e l’invito a una nuova generazione di cattolici impegnati in politica. La difesa della centralità della persona umana come compito primario dei credenti impegnati nel governo della città terrena– 7. (segue) L’impegno a favore della promozione di un concetto positivo di laicità, aperto alla Trascendenza − 8. (segue) La politica come forma singolare di realizzazione della carità – 9. (segue) La dottrina sociale della Chiesa come strumento di formazione essenziale e guida sicura per i fedeli laici impegnati nell’ambito socio-politico – 10. Considerazioni conclusive. Doveri, rispettivi, dello Stato e della Chiesa affinché si conservino, o se necessario si creino le condizioni esterne idonee e necessarie allo svolgimento dei compiti dei christifideles laici nella polis.
description: Stato, Chiese e pluralismo confessionale, 2011: 28 novembre
Evaluating pipelines that detect functional connectivity from EEG
Creators: name: Pellegrini, Franziska
name: Nikulin, Vadim
name: Haufe, Stefan
Publisher: name: G-Node
Year: 2021
Subjects: Computational Neuroscience
Data analysis, machine learning, neuroinformatics

description: Bernstein Conference 2021 abstract. http://bernstein-conference.de
Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure
Creators: name: Johnson, Amber N.
name: Dickinson, John
name: Nelson, Amy
name: Gaurav, Rohit
name: Kudrna, Katrina
name: Evans, Scott E.
name: Janike, Katherine
name: Wyatt, Todd A.
name: Poole, Jill A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway neutrophil influx and release of pro-inflammatory cytokines was essentially abrogated in global MyD88-deficient mice, yet these mice demonstrate an increase in airway epithelial cell mucin expression. To further elucidate the role of MyD88-dependent responses specific to lung airway epithelial cells in response to ODE in vivo, the surfactant protein C protein (SPC) Cre+ embryologic expressing airway epithelial cells floxed for MyD88 to disrupt MyD88 signaling were utilized. The inducible club cell secretory protein (CCSP) Cre+, MyD88 floxed, were also developed. Using an established protocol, mice were intranasally instilled with ODE or saline once or daily up to 3 weeks. Mice with MyD88-deficient SPC+ lung epithelial cells exhibited decreased neutrophil influx following ODE exposure once and repetitively for 1 week without modulation of classic pro-inflammatory mediators including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and neutrophil chemoattractants. This protective response was lost after 3 weeks of repetitive exposure. ODE-induced Muc5ac mucin expression at 1 week was also reduced in MyD88-deficient SPC+ cells. Acute ODE-induced IL-33 was reduced in MyD88-deficient SPC+ cells whereas serum IgE levels were increased at one week. In contrast, mice with inducible MyD88-deficient CCSP+ airway epithelial cells demonstrated no significant difference in experimental indices following ODE exposure. Collectively, these findings suggest that MyD88-dependent signaling targeted to all airway epithelial cells plays an important role in mediating neutrophil influx and mucin production in response to acute organic dust exposures.
Unique Fock quantization of scalar cosmological perturbations
Creators: name: Fernández-Méndez, Mikel
name: Marugán, Guillermo A. Mena
name: Olmedo, Javier
name: Velhinho, José M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the ambiguities in the Fock quantization of the scalar perturbations of a Friedmann-Lemaître-Robertson-Walker model with a massive scalar field as matter content. We consider the case of compact spatial sections (thus avoiding infrared divergences), with the topology of a three-sphere. After expanding the perturbations in series of eigenfunctions of the Laplace-Beltrami operator, the Hamiltonian of the system is written up to quadratic order in them. We fix the gauge of the local degrees of freedom in two different ways, reaching in both cases the same qualitative results. A canonical transformation, which includes the scaling of the matter field perturbations by the scale factor of the geometry, is performed in order to arrive at a convenient formulation of the system. We then study the quantization of these perturbations in the classical background determined by the homogeneous variables. Based on previous work, we introduce a Fock representation for the perturbations in which: (a) the complex structure is invariant under the isometries of the spatial sections and (b) the field dynamics is implemented as a unitary operator. These two properties select not only a unique unitary equivalence class of representations, but also a preferred field description, picking up a canonical pair of field variables among all those that can be obtained by means of a time-dependent scaling of the matter field (completed into a linear canonical transformation). Finally, we present an equivalent quantization constructed in terms of gauge-invariant quantities. We prove that this quantization can be attained by a mode-by-mode time-dependent linear canonical transformation which admits a unitary implementation, so that it is also uniquely determined.
description: 19 pages, minor impovementes included, typos corrected
The optical view of the X-ray Ultra Fast Outflow in the Narrow Line Sy1 IRAS17020+4544 seen with MEGARA/GTC
Creators: name: Bellocchi, Enrica
name: Longinotti, Anna Lia
name: Salomé, Quentin
name: Castillo-Morales, África
name: Gil de Paz, Armando
Publisher: name: Zenodo
Year: 2025

description: Outflows in galaxies play a crucial role in AGN feedback by transporting mass and energy from the nucleus to larger scales through winds and jets, as observed across multiple wavelengths. Theoretical models suggest that quasar feedback originates from sub-relativistic Ultra Fast Outflows (UFOs) (~10^4 km/s) launched at accretion disk scales, which interact with the ISM, slowing down and cooling as they propagate outward. This process results in less ionized outflows at larger scales, observed in the optical and molecular phases. The presence of energy-conserving winds can be tested by comparing the X-ray, ionized, and molecular gas phases.IRAS 17020+4544, a Narrow Line Seyfert 1 and LIRG, is an ideal target for such a study, as it hosts a multi-component X-ray UFO, a molecular outflow resolved with NOEMA, and an elongated VLBI radio jet that may induce shocks in the ISM. Using MEGARA/GTC data, we characterize the ionized outflow over ~140 kpc^2, covering the region where the powerful molecular outflow is resolved. By deriving its kinematics and energetics (velocity, mass, kinetic power, momentum, etc.), we aim to assess the energy budget of the outflow and compare it with the molecular and X-ray phases. This work will provide key insights into AGN feedback efficiency and the conditions under which outflows retain their energy as they expand ("energy-conserving" regime). 

Esta presentación formó parte de la conferencia III GUAIX Scientific Meeting UCM 2024. El programa de la conferencia está disponible en Zenodo con DOI: 10.5281/zenodo.14674077.
La laicità francese: “aperta”, “positiva” o “im-positiva”?
Creators: name: D'Arienzo, Maria
Publisher: name: Università degli Studi di Milano
Year: 2011
Subjects: Diritto ecclesiastico comparato e straniero

description: Il testo riproduce il paper della relazione “La laicità francese: vecchie costanti e nuove variabili” tenuta al Convegno: “La laicità e gli ordinamenti giuridici: principi, valori e regole”, organizzato dalla Facoltà di Scienze politiche dell’Università della Calabria, in data 5 maggio 2011, modificato nel titolo e aggiornato per la pubblicazione in corso sulla Rivista Diritto e Religioni, n. 2/2011.

SOMMARIO: 1. Premessa – 2. Dalla “laicità aperta” alla “laicità positiva” – 3. Laicità e libertà religiosa. Le ventisei proposizioni del Pacte Républicaine: laïcité pour mieux vivre ensemble dell’UMP – 4. Dalla “laicità positiva” alla “laicità im-positiva” – 5. La strumentalizzazione politica del dibattito sulla laicità.
description: Stato, Chiese e pluralismo confessionale, 2011: 5 dicembre
The role of NMDA receptors in excitotoxicity
Creators: name: Bakshi, Deeksha
Publisher: name: University of British Columbia
Year: 2013

description: NMDA receptors are glutamate-gated cation channels named after their prototypical selective agonist NMDA. The channels occur as multiple subtypes, which are formed from interactions between different receptor subunits. NMDA receptor subunits are classified into three families: NR1, NR2A-D, and NR3A, B. NMDA receptors are implicated in HD pathology. During HD, a subset of medium-sized aspiny interneurons in the striatum that co-localize SST, NPY, and the enzyme NOS are selectively spared. In contrast, medium-sized spiny cells that constitute 80 % of all striatal neurons undergo selective neurodegeneration. While it was suggested that the interneurons survive because they lack NMDA receptors, studies including from our lab have shown the presence of NR1 in SST-positive striatal neurons. The finding of NR1 expression and co-localization with SST-positive neurons indicates that NMDA receptor-induced toxicity may be regulated in a receptor-specific manner. Therefore, the present study was conducted to investigate whether NMDA application leads to toxicity that is receptor-specific in HEK293 cells stably transfected with NR1, NR2A, or NR2B. The main findings of this study indicate that NMDA application causes cell death, which varies in intensity and nature, depending upon the NMDA concentration applied, and the receptor-type expressed by the cells. Cells expressing NR1 were found to undergo apoptosis but not necrosis, while cells expressing NR2A/NR2B underwent both apoptosis and necrosis in a receptor-specific manner. In cells expressing NR2A/NR2B, exposure to low concentrations of NMDA resulted in cell death that was predominantly apoptotic. In contrast, exposure to high concentrations of NMDA produced mostly necrosis. In cells expressing NR1, NMDA application caused apoptosis, which exhibited a gradual increase in response to greater concentrations of NMDA. In addition, cell death through apoptosis and/or necrosis was determined to be the greatest at all NMDA concentrations in cells expressing NR2B, followed by those expressing NR2A, and then NR1. Taken together, these results indicate that the activation of receptors formed by NR1, NR2A, or NR2B have different toxic consequences. Thus, the selective neurodegeneration observed during HD may be due to the variation in expression levels of NR1, NR2A, and NR2B between medium-sized aspiny interneurons and medium-sized spiny projection neurons.
Electroweak Symmetry Breaking in the DSSM
Creators: name: Heckman, Jonathan J.
name: Kumar, Piyush
name: Vafa, Cumrun
name: Wecht, Brian
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the theoretical and phenomenological consequences of modifying the Kahler potential of the MSSM two Higgs doublet sector. Such modifications naturally arise when the Higgs sector mixes with a quasi-hidden conformal sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field space due to the presence of quasi-hidden sector states which get their mass from the Higgs vevs. The presence of these extra states leads to the fact that even as Delta approaches 1, the DSSM does not reduce to the MSSM. In particular, the Higgs can naturally be heavier than the W- and Z-bosons. Perturbative gauge coupling unification, a large top quark Yukawa, and consistency with precision electroweak can all be maintained for Delta close to unity. Moreover, such values of Delta can naturally be obtained in string-motivated constructions. The quasi-hidden sector generically contains states charged under SU(5)_GUT as well as gauge singlets, leading to a rich, albeit model-dependent, collider phenomenology.
description: v3: 40 pages, 3 figures, references added, typos corrected
title: Why is middle cerebral artery plaque augmented by contrast media? Comparison of contrast-enhanced T1 MR using silicon models with middle cerebral artery stenosis and variable clinical patterns
Creators: name: Kim, Sol Ki
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Ischaemia / Infarction
subject: Embolism / Thrombosis
subject: Technology assessment
subject: Experimental investigations
subject: MR-Angiography
subject: MR
subject: Vascular
subject: Neuroradiology brain
subject: Arteries / Aorta

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To compare the contrast enhancement patterns between silicon models(SM) of MCA stenosis and clinical conditions such as MCA occlusion and...
Aspects of Three-dimensional Spin-4 Gravity
Creators: name: Tan, H. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We discuss some interesting holographical aspects of three-dimensional higher-spin gravity with a negative cosmological constant in the framework of SL(4, R) \times SL(4, R) Chern-Simons theory. Using a recently found technique, we construct explicitly a solution that can be interpreted as spin-4 generalization of the BTZ solution, and demonstrate how W_4 symmetry and the higher-spin Ward identities arise from the bulk equations of motion coupled to spin-3 and spin-4 currents. We match the eigenvalues of a Wilson loop along the time-like direction of the BTZ to that of the spin-4 solution, and show that this yields remarkably consistent gravitational thermodynamics for the latter. This furnishes an important, concrete supporting example for a recent proposal to understand spacetime geometries in three-dimensional higher-spin gravity formulated via SL(N, R) \times SL(N, R) Chern-Simons theories.
description: 29 pages; included a note on trace convention in Sec. 2, 3.4 and added acknowledgments
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
Creators: name: Phelps, Drake W.
name: Palekar, Anika I.
name: Conley, Haleigh E.
name: Ferrero, Giuliano
name: Driggers, Jacob H.
name: Linder, Keith E.
name: Kullman, Seth W.
name: Reif, David M.
name: Sheats, M. Katie
name: DeWitt, Jamie C.
name: Yoder, Jeffrey A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Per- and polyfluoroalkyl substances (PFASs) are used in a multitude of processes and products, including nonstick coatings, food wrappers, and fire-fighting foams. These chemicals are environmentally-persistent, ubiquitous, and can be detected in the serum of 98% of Americans. Despite evidence that PFASs alter adaptive immunity, few studies have investigated their effects on innate immunity. The report here presents results of studies that investigated the impact of nine environmentally-relevant PFASs [e.g. perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid potassium salt (PFOS-K), perfluorononanoic acid (PFNA), perfluorohexanoic acid (PFHxA), perfluorohexane sulfonic acid (PFHxS), perfluorobutane sulfonic acid (PFBS), ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX), 7H-perfluoro-4-methyl-3,6-dioxa-octane sulfonic acid (Nafion byproduct 2), and perfluoromethoxyacetic acid sodium salt (PFMOAA-Na)] on one component of the innate immune response, the neutrophil respiratory burst. The respiratory burst is a key innate immune process by which microbicidal reactive oxygen species (ROS) are rapidly induced by neutrophils in response to pathogens; defects in the respiratory burst can increase susceptibility to infection. The study here utilized larval zebrafish, a human neutrophil-like cell line, and primary human neutrophils to ascertain whether PFAS exposure inhibits ROS production in the respiratory burst. It was observed that exposure to PFHxA and GenX suppresses the respiratory burst in zebrafish larvae and a human neutrophil-like cell line. GenX also suppressed the respiratory burst in primary human neutrophils. This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function.
On the Extension of the Erdos-Mordell Type Inequalities
Creators: name: Malesevic, Branko
name: Petrovic, Maja
name: Obradovic, Marija
name: Popkonstantinovic, Branislav
Publisher: name: arXiv
Year: 2012
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: We discuss the extension of inequality R_A >= c/a * r_b + b/a * r_c to the plane of triangle ABC. Based on the obtained extension, in regard to all three vertices of the triangle, we get the extension of Erdos-Mordell inequality, and some inequalities of Erdos-Mordell type.
title: Inequality in Germany: Decrease in Gap for Gross Hourly Wages since 2014, but Monthly and Annual Wages Remain on Plateau
Creators: name: Grabka, Markus M.
name: Schröder, Carsten
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: D31 Personal Income, Wealth, and Their Distributions
subject: I31 General Welfare
subject: I32 Measurement and Analysis of Poverty
subject: Wage inequality
subject: monthly earnings
subject: annual earnings
subject: SOEP

description: Despite the booming German labor market, wage inequality is still a relevant issue. In the present study, the authors report on the changes in wages and their distribution between 1992 and 2016. In addition to real contractual gross hourly wages, we closely examined gross monthly and annual wages. Based on Socio-Economic Panel (SOEP) data, the results show that wage inequality rose significantly between 1992 and 2005, in particular with respect to monthly and annual wages. Since then inequality in monthly and annual wages has plateaued at its 2005 level. Inequality in hourly wages has decreased only since 2014, and between 2013 and 2016, average real gross hourly wages rose by five percent after a longer phase of stagnation. For the lowest ten percent of the population, they rose by 13 percent—a rate related to the implementation of sector-specific wages and the statutory minimum wage. However, these minimum wages obviously did not affect monthly and annual wages as anticipated.
description: DIW Weekly Report, 8 (2018), 9, S. 83-92
Multi-Centered Black Hole Flows
Creators: name: Yeranyan, Armen
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe the systematical construction of the first order formalism for multi-centered black holes with flat three dimensional base-space, within the so-called $T^{3}$ model of N=2, D=4 ungauged Maxwell-Einstein supergravity. The three possible flow classes (BPS, composite non-BPS and almost-BPS) are analyzed in detail, and various solutions, such as single-centered (static or under-rotating) and all known multi-centered black holes, are recovered in this unified framework. We also consider the possibility of obtaining new solutions. The almost-BPS class is proved to split into two general sub-classes, corresponding to a positive or negative value of the duality-invariant polynomial for the total charge; the well known almost BPS system is shown to be a particular solution of the second sub-class.
description: 17 pages,no figures
title: Computed Tomography Dacryocystography for evaluation of the lacrimal system
Creators: name: Maturi, Mariacristina
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Pathology
subject: Dacryocystography
subject: CT
subject: Eyes

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To acknowledge the use of Computed Tomography Dacryocystography (Dacryo-CT) for the study of lacrimal drainage apparatus pathologies, in order to highlight the presence of obstruction and to identify anomalies and anatomical variants of the...
title: EU Roaming Regulation: Theoretical Model Suggests a Positive Assessment
Creators: name: Baake, Pio
name: Wagner, Lilo
Publisher: name: DIW - Deutsches Institut für Wirtschaftsforschung
Year: 2018
Subjects: subject: L51 Economics of Regulation
subject: L96 Telecommunications
subject: D04 Microeconomic Policy: Formulation; Implementation; Evaluation
subject: D86 Economics of Contract: Theory
subject: EU Roaming Regulation
subject: Regulation Theory
subject: Microeconomic Theory
subject: Telecommunications Policy

description: Since June 15, 2017, mobile network operators in the European Economic Area may not impose surcharges for making telephone calls, sending text messages, or using data services in other EEA countries. The regulation was designed to create a digital domestic market without adversely affecting consumers. The regulation raises the expectation of changes in mobile network operators’ tariff structures. Theoretical examination shows that as long as mobile network operators do not exclude a roaming option for users who travel only occasionally, everyone will benefit from the regulations—even occasional travelers. In this case, positive effects are also anticipated for overall social welfare. However, negative effects are likely if some tariffs exclude a roaming option. The market result is highly dependent on how strongly consumers differ in their user behavior. The fact that all three mobile network operators in Germany exclusively offer tariffs with roaming options is evidence in favor of a positive assessment of the EU regulatory measures.
description: DIW Weekly Report, 8 (2018), 6, S. 59-64
Differential classification between Schizophrenia and Bipolar Disorder using multiple brain parcellation ensemble machine learning with resting-state fMRI
Creators: name: Rajeswari, Dilip
name: Kalmady, Sunil V.
name: Agrawal, Rimjhim
Publisher: name: G-Node
Year: 2021
Subjects: Computational Neuroscience
Data analysis, machine learning, neuroinformatics

description: Bernstein Conference 2021 abstract. http://bernstein-conference.de
Anisotropic spin-fluctuations in SmCoPO revealed by 31^P NMR measurement
Creators: name: Majumder, Mayukh
name: Ghoshray, K.
name: Ghoshray, A.
name: Pal, Anand
name: Awana, V. P. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: 31^P NMR spectral features in polycrystalline SmCoPO reveal an axially symmetric local magnetic field. At low temperature, the anisotropy of the internal magnetic field increases rapidly, with K_ab increasing faster than that of K_c. The dominant contribution to this anisotropy arises from Sm-4f electron contribution over that of Co-3d. The intrinsic width 2*(Beta) deviates from linearity with respect to bulk susceptibility below 170 K due to the enhancement of (1/T_2)dynamic, which along with the continuous increase of anisotropy in the internal magnetic field is responsible for the wipe out effect of the NMR signal, well above T_C. 1/T_1 shows large anisotropy confirming a significant contribution of Sm-4f electron spin fluctuations to 1/T_1, arising from indirect RKKY type exchange interaction indicating a non-negligible hybridization between Sm-4f orbitals and the conduction band, over the itinerant character of the Co-3d spins. This anisotropy in originates from the orientation dependence of chi"(q,omega). The 3d-spin fluctuations in the ab plane is 2D FM in nature, while along the c-axis, a signature of a weak 2D AFM spin fluctuations superimposed on weak FM spin-fluctuations even in a field of 7 T and far above T_N is observed. The enhancement of this AFM fluctuations of the Co-3d spins along c-axis, at further low temperature is responsible to drive the system to an AFM ordered state.