cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Neues zur galläkischen Kriegerstatue von Villar de Barrio (Provinz Orense)
title: Neues zur galläkischen Kriegerstatue von Villar de Barrio (Provinz Orense)
titleType: Subtitle
Creators: name: Maier Allende, Jorge
name: Schattner, Thomas G.
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: keltische Großlastik
subject: galläkische Kriegerstatue
subject: Forschungsgeschichte
subject: Celtic monumental sculpture
subject: Gallaecian warrior
subject: statue
subject: historiography
subject: escultura monumental celta
subject: estatua de guerrero galaica
subject: historiografía

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Durch den Fund der seit 100 Jahren vermissten Zeichnung der Kriegerstatue von Villar de Barrio im Archiv der ›Real Academia de la Historia‹ in Madrid wird die Einordnung dieser Figur unter archäologischen und kunstgeschichtlichen Gesichtspunkten möglich. Sie entspricht in einigen Details den Merkmalen der späteren Kriegerstatuen, die bereits in derrömischen Kaiserzeit entstanden sind. Die Statue ist wahrscheinlich kurz vor Anfertigung der Zeichnung in den 1830er Jahren als Markierung der Ortsgrenze zwischen zwei Dörfern aufgestellt worden.
Early Career Research Consortium
Creators: name: Melzer, Sylvia
Publisher: name: Universität Hamburg
Year: 2021
Subjects: UWA
CSMC
KI2021
AI
DL01
Data Linking
ECR

description: The early career research consortium has provided young researchers from any subject area within AI with the opportunity to present their ideas and receive feedback at an early stage of at their scientific work. We have invited young researchers to present their research and established connections with new researchers.

The early career research consortium has also provided to discuss their research interests and career objectives with established researchers in AI and to network with other participants.

The accepted contributions are:

 Jan Martin Spreitzenbarth: KI 2021 DC: AI Methods in Procurement (download submission)

 Juliane Ressel: Adoption of Artificial Intelligence in the Insurance Sector: Creating a Governance Framework to Ensure Consumer Protection (download submission)

 Sumaiya Suravee:  Methods for Automated Learning of Semantic Structures from Textual Data

 (download submission)

 Honghu Xue: Efficient Deep Reinforcement Learning Using Model-based RL (download submission)

 Vadym Gryshchuk: Encoding of Semantic Knowledge in Convolutional Neural Networks: Visual and Textual Explanations

 Mena Leemhuis: Cone-based Embeddings for Logics with Negation (download submission)

The submitted abstracts and presentations are in this upload for which permission to publish has been granted.
description: The Early Career Research Consortium was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796.
title: Proteasomal degradation of glycated proteins depends on substrate unfolding
title: preferred degradation of moderately modified myoglobin
titleType: Subtitle
Creators: name: Raupbach, Jana
name: Ott, Christiane
name: Koenig, Jeannette
name: Grune, Tilman
Publisher: name: Universität Potsdam
Year: 2022
Subjects: subject: 570 Biowissenschaften; Biologie
subject: 610 Medizin und Gesundheit

description: The Maillard reaction generates protein modifications which can accumulate during hyperglycemia or aging and may have inflammatory consequences. The proteasome is one of the major intracellular systems involved in the proteolytic degradation of modified proteins but its role in the degradation of glycated proteins is scarcely studied. In this study, chemical and structural changes of glycated myoglobin were analyzed and its degradation by 20S proteasome was studied. Myoglobin was incubated with physiological (5-10 mM), moderate (50-100 mM) and severe levels (300 mM) of glucose or methylglyoxal (MGO, 50 mM). Glycation increased myoglobin's fluorescence and surface hydrophobicity. Severe glycation generated crosslinked proteins as shown by gel electrophoresis. The concentration of advanced glycation endproducts (AGEs) N-epsilon-carboxymethyl lysine (CML), N-epsilon-carboxyethyl lysine (CEL), methylglyoxal-derived hydroimidazolone-1 (MG-H1), pentosidine and pyrraline was analyzed after enzymatic hydrolysis followed by UPLC-MS/MS. Higher concentrations of glucose increased all analyzed AGEs and incubation with MGO led to a pronounced increase of CEL and MG-H1. The binding of the heme group to apo-myoglobin was decreased with increasing glycation indicating the loss of tertiary protein structure. Proteasomal degradation of modified myoglobin compared to native myoglobin depends on the degree of glycation: physiological conditions decreased proteasomal degradation whereas moderate glycation increased degradation. Severe glycation again decreased proteolytic cleavage which might be due to crosslinking of protein monomers. The activity of the proteasomal subunit beta 5 is influenced by the presence of glycated myoglobin. In conclusion, the role of the proteasome in the degradation of glycated proteins is highly dependent on the level of glycation and consequent protein unfolding.
Many-body density of states of bosonic and fermionic gases: a combinatorial approach
Creators: name: Echter, Carolyn
name: Maier, Georg
name: Urbina, Juan Diego
name: Lewenkopf, Caio
name: Richter, Klaus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 530 Physik

description: We use a combinatorial approach to obtain exact expressions for the many-body density of states of fermionic and bosonic gases with equally spaced single-particle spectra. We identify a mapping that reveals a remarkable property, namely, fermionic and bosonic gases have the same many-body density of states, up to a shift corresponding to ground state energy. Additionally, we show that there is a regime, comprising the validity range of the Bethe approximation, where the many-body density of states becomes independent of the number of particles.
title: A propósito de un infundibulum etrusco hallado en aguas de la Bahía de Xàbia (Alacant)
title: A propósito de un infundibulum etrusco hallado en aguas de la Bahía de Xàbia (Alacant)
titleType: Subtitle
Creators: name:  Vives-Ferrándiz Sánchez, Jaime
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Infundibulum
subject: Xàbia (Alicante)
subject: Trinksitten
subject: phönizischer Handel
subject: infundibulum
subject: Xàbia (Alicante)
subject: drinking rites
subject: Phoenician commerce
subject: infundibulum
subject: Xàbia (Alacant)
subject: prácticas de consumo del vino
subject: comercio fenicio

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Se presenta un objeto etrusco de bronce, hallado en aguas de la bahía de Xàbia (Alacant) y clasificado como un infundibulum con mango de lira. Paralelos en Etruria indican que los del tipo de lira son los ejemplares más antiguos, remontándose al siglo VI a. C. Estos objetos se utilizaban con el servicio de bebida y tenían una función doble: por un lado servían como embudos para introducir líquidos en recipientes de boca estrecha y, por otro lado, como coladores o filtros para las impurezas que éstos pudieran tener. Para discutir los usos del infundibulum en la costa oriental peninsular se debe tener en cuenta que las vías comerciales no eran exclusivamente etruscas, sino que su llegada se produjo dentro del contexto de los intercambios fenicios. Lo relevante es que en este ámbito están ausentes tanto las ánforas vinarias como las copas etruscas. De hecho el vino consumido en este periodo de tiempo es vino fenicio importado del sur peninsular o vino local documentado en el Alt de Benimaquia y, por otra parte, el vino se consumía en copas hechas a mano de tradición indígena o bien en copas de tipo fenicio. En consecuencia se descarta que bronces etruscos como son los infundibula, olpes o bandejas halladas en diversos yacimientos alicantinos impliquen un uso propio del simposio etrusco o griego. Se puede plantear la diversificación en la práctica del consumo de vino en algunos contextos de finales del siglo VII y primera mitad del siglo VI, contextos a los que están asociadas las ánforas y los trípodes fenicios. Las primeras son contenedores de vino en la mayor parte de los casos y los segundos son morteros destinados, entre otros usos, a la preparación de sustancias para añadir al vino, según una práctica de consumo difundida por los grupos fenicios y que está, además, en contacto con el mundo etrusco. Es tentador relacionar el infundibulum con usos vinculados a las mezclas del vino, al igual que el uso de trípodes fenicios por parte de grupos indígenas o fenicios. Con todo, la pieza de Xàbia puede formar parte de un ajuar de banquete de tipo aristocrático, adoptado localmente, por lo que más que como un objeto etrusco hay que verlo como una pieza excepcional de uso restringido, que formara parte de un contexto local concreto y que hubiera sido adaptado por los grupos locales para ser utilizado en prácticas festivas importantes. Y estas prácticas se pueden relacionar con la formación de una identidad propia que caracterizará a la élite ibérica.
Manganese(II) Molecular Sources for Plasma-Assisted CVD of Mn Oxides and Fluorides: From Precursors to Growth Process
Creators: name: Tabacchi, Gloria
Publisher: name: figshare
Year: 2018
Subjects: subject: 100708 Nanomaterials
subject: FOS: Nanotechnology
subject: 100712 Nanoscale Characterisation
subject: 100799 Nanotechnology not elsewhere classified
subject: 100706 Nanofabrication, Growth and Self Assembly

description: Supporting data for the article:Manganese(II) Molecular Sources for Plasma-Assisted CVD of Mn Oxides and Fluorides: From Precursors to Growth Process
byDavide Barreca , Giorgio Carraro , Ettore Fois, Alberto Gasparotto, Filippo Gri, Roberta Seraglia, Martin Wilken, Alfonso Venzo, Anjana Devi , Gloria Tabacchi*, and Chiara Maccato*
First published December 21, 2017, in:J. Phys. Chem. CDOI: 10.1021/acs.jpcc.7b10277
Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs
Creators: name: Pyta, Krystian
name: Skrzypczak, Natalia
name: Ruszkowski, Piotr
name: Bartl, Franz
name: Przybylski, Piotr
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The influence of base type, temperature, and solvent on regioselective C(9)/C(10) “click” modifications within the tropolone ring of colchiceine (2) is investigated. New ether derivatives of 2, bearing alkyne, azide, vinyl, or halide aryl groups enable assembly of the alkaloid part with heterocycles or important biomolecules such as saccharides, geldanamycin or AZT into hybrid scaffolds by dipolar cycloaddition (CuAAC) or Heck reaction. Compared to colchicine (1) or colchiceine (2), ether congeners, as e.g. 3e [IC50s(3e) ∼ 0.9 nM], show improved or similar anticancer effects, whereby the bulkiness of the substituents and the substitution pattern of the tropolone proved to be essential. Biological studies reveal that expanding the ether arms by terminal basic heterocycles as quinoline or pyridine, decreases the toxicity in HDF cells at high anticancer potency (IC50s ∼ 1–2 nM). Docking of ether and hybrid derivatives into the colchicine pocket of αGTP/β tubulin dimers reveals a relationship between the favourable binding mode and the attractive anticancer potency.
Additional file 3 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 3: Figure S3. MCI and control brains have similar amounts of soluble protein. Amido black stained Western blot of control and MCI cortex RIPA-soluble (supernatant) fractions. Each lane is a cortical sample from one individual, presented in the same order as the cases in Table S2 (17–36). The ratios reflecting the total protein in the various quadrants are presented along with tubulin. The 51 kDa protein (tubulin) was excluded from the analysis of each quadrant. P values are given. Data are presented as mean ± SEM (n = 10/group).
What are the gaps in cardiovascular risk assessment and management in primary care for Māori and Pacific people in Aotearoa New Zealand: protocol for a systematic review
Creators: name: Brewer, Karen
name: Grey, Corina
name: Paynter, Janine
name: Winter-Smith, Julie
name: Hanchard, Sandra
name: Selak, Vanessa
name: Ameratunga, Shanthi
name: Harwood, Matire
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cardiology
subject: Medicine and Health Sciences
subject: Family Medicine
subject: Medical Specialties

description: A protocol for a systematic review.
Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
Creators: name: Narczyk, Marta
name: Wojtyś, Marta Ilona
name: Ašler, Ivana Leščić
name: Žinić, Biserka
name: Luić, Marija
name: Jagusztyn-Krynicka, Elżbieta Katarzyna
name: Štefanić, Zoran
name: Bzowska, Agnieszka
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Helicobacter pylori represents a global health threat with around 50% of the world population infected. Due to the increasing number of antibiotic-resistant strains, new strategies for eradication of H. pylori are needed. In this study, we suggest purine nucleoside phosphorylase (PNP) as a possible new drug target, by characterising its interactions with 2- and/or 6-substituted purines as well as the effect of these compounds on bacterial growth. Inhibition constants are in the micromolar range, the lowest being that of 6-benzylthio-2-chloropurine. This compound also inhibits H. pylori 26695 growth at the lowest concentration. X-ray structures of the complexes of PNP with the investigated compounds allowed the identification of interactions of inhibitors in the enzyme’s base-binding site and the suggestion of structures that could bind to the enzyme more tightly. Our findings prove the potential of PNP inhibitors in the design of drugs against H. pylori.
Metallicity calibrations for dwarf stars and giants in the Geneva photometric system
Creators: name: Netopil, Martin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the most homogeneous $Geneva$ seven-colour photometric system to derive new metallicity calibrations for early A- to K-type stars that cover both, dwarf stars and giants. The calibrations are based on several spectroscopic data sets that were merged to a common scale, and we applied them to open cluster data to obtain an additional proof of the metallicity scale and accuracy. In total, metallicities of 54 open clusters are presented. The accuracy of the calibrations for single stars is in general below 0.1 dex, but for the open cluster sample with mean values based on several stars we find a much better precision, a scatter as low as about 0.03 dex. Furthermore, we combine the new results with another comprehensive photometric data set to present a catalogue of mean metallicities for more than 3000 F and G-type dwarf stars with $σ\sim 0.06$ dex. The list was extended by more than 1200 hotter stars up to about 8500 K (or spectral type A3) by taking advantage of their almost reddening free characteristic in the new $Geneva$ metallicity calibrations. These two large samples are well suited as primary or secondary calibrators of other data, and we already identified about 20 spectroscopic data sets that show offsets up to about 0.4 dex.
description: 16 pages, 14 figures, 5 tables, accepted by MNRAS
Gas Accretion and Galactic Chemical Evolution: Theory and Observations
Creators: name: Finlator, Kristian
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: This chapter reviews how galactic inflows influence galaxy metallicity. The goal is to discuss predictions from theoretical models, but particular emphasis is placed on the insights that result from using models to interpret observations. Even as the classical G-dwarf problem endures in the latest round of observational confirmation, a rich and tantalizing new phenomenology of relationships between $M_*$, $Z$, SFR, and gas fraction is emerging both in observations and in theoretical models. A consensus interpretation is emerging in which star-forming galaxies do most of their growing in a quiescent way that balances gas inflows and gas processing, and metal dilution with enrichment. Models that explicitly invoke this idea via equilibrium conditions can be used to infer inflow rates from observations, while models that do not assume equilibrium growth tend to recover it self-consistently. Mergers are an overall subdominant mechanism for delivering fresh gas to galaxies, but they trigger radial flows of previously-accreted gas that flatten radial gas-phase metallicity gradients and temporarily suppress central metallicities. Radial gradients are generically expected to be steep at early times and then flattened by mergers and enriched inflows of recycled gas at late times. However, further theoretical work is required in order to understand how to interpret observations. Likewise, more observational work is needed in order to understand how metallicity gradients evolve to high redshifts.
description: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springer. 29 pages, 2 figures
title: Espadas miniaturizadas en las necrópolis del Noreste de la Península Ibérica
title: Espadas miniaturizadas en las necrópolis del Noreste de la Península Ibérica
titleType: Subtitle
Creators: name:  Graells i Fabregat, Raimon
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Schwerter
subject: Erste Eisenzeit
subject: altiberische Epoche
subject: Katalonien
subject: Statussymbole
subject: swords
subject: First Iron Age
subject: Early Iberian Period
subject: Catalonia
subject: symbols of status
subject: espadas
subject: Primera Edad del Hierro
subject: Ibérico Antiguo
subject: Cataluña
subject: indicador de status social

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Las espadas en miniatura aparecidas en algunas necrópolis de Cataluña, de la primera Edad del Hierro y del Ibérico antiguo, han llevado a plantear una serie de interrogantes sobre su utilidad y significado. Estas miniaturas, que no sobrepasan los 6 cm de largo, se relacionan con distintos aspectos del nacimiento de una aristocracia como parte de un proceso de estratificación social, identificando a sus poseedores como personajes singulares dentro de sus respectivas comunidades. Esta singularidad social relacionada con la escasez de espadas, tanto a tamaño real como en miniatura, en las necrópolis del nordeste peninsular, permite proponer estos objetos como indicadores de la posición social de su dueño, que sólo podía estar relacionada con un status político-militar. El sistema de trabajo utilizado es el siguiente: descripción de unos preceptos básicos sobre la miniaturización de objetos, catálogo de los ejemplares catalanes y otro de sus paralelos (a tamaño real y miniaturizados) y dos capítulos de conclusiones, el primero sobre la funcionalidad de las espaditas y el segundo sobre su función social como indicador de status.
The thermal state and interior structure of Mars
Creators: name: Plesa, A.-C.
name: Padovan, S.
name: Tosi, Nicola
name: Breuer, D.
name: Grott, M.
name: Wieczorek, M. A.
name: Spohn, T.
name: Smrekar, S. E.
name: Banerdt, W. B.
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 550 Geowissenschaften
subject: InSight
subject: Mars
subject: interior dynamics
subject: thermal evolution
subject: interior structure

description: ©2018. American Geophysical Union
description: The present‐day thermal state, interior structure, composition, and rheology of Mars can be constrained by comparing the results of thermal history calculations with geophysical, petrological, and geological observations. Using the largest‐to‐date set of 3‐D thermal evolution models, we find that a limited set of models can satisfy all available constraints simultaneously. These models require a core radius strictly larger than 1,800 km, a crust with an average thickness between 48.8 and 87.1 km containing more than half of the planet's bulk abundance of heat producing elements, and a dry mantle rheology. A strong pressure dependence of the viscosity leads to the formation of prominent mantle plumes producing melt underneath Tharsis up to the present time. Heat flow and core size estimates derived from the InSight (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) mission will increase the set of constraining data and help to confine the range of admissible models.
Three-dimensional polycaprolactone-bioactive glass composite scaffolds: Effect of particle size and volume fraction on mechanical properties and in vitro cellular behavior
Creators: name: Elnaz Tamjid
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: In this study, highly porous polycaprolactone-based composites (90% porosity) with hierarchical pore structure (400–500 µm) and nanotopographical features were prepared by 3D printing. 45S5 Bioglass particles with different sizes (<100 nm; 250 nm; 6 µm) and concentrations (2, 6, and 10 vol%) were utilized to attain improved mechanical strength and bioactivity. The micrometric particles embedded in the polymer matrix enhanced the elastic modules up to 235%. The ultrafine particles decorated the struts and affected nanotopography, hydrophilicity, and nanohardness by about 100%. The rate of pore filing lowers in the presence of nanoparticles as compared with microparticles.
Generalized Grassmann variables for quantum kit (k-level) systems and Barut-Girardello coherent states for su(r+1) algebras
Creators: name: Daoud, M.
name: Gouba, L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper concerns the construction of $su(r+1)$ Barut--Girardello coherent states in term of generalized Grassmann variables. We first introduce a generalized Weyl-Heisenberg algebra ${\cal A}(r)$ ($r \geq 1$) generated by $r$ pairs of creation and annihilation operators. This algebra provides a useful framework to describe qubit and qukit ($k$-level) systems. It includes the usual Weyl-Heisenberg and $su(2)$ algebras. We investigate the corresponding Fock representation space. The generalized Grassmann variables are introduced as variables spanning the Fock--Bargmann space associated with the algebra ${\cal A}(r)$. The Barut--Girardello coherent states for $su(r+1)$ algebras are explicitly derived and their over--completion properties are discussed.
description: 23 pages
title: A idade do ferro do Sul de Portugal. Estado da investigação
title: A idade do ferro do Sul de Portugal. Estado da investigação
titleType: Subtitle
Creators: name: Arruda, Ana Margarida
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Algarve
subject: Eisenzeit
subject: Phönizier
subject: Einheimische
subject: Kolonisierung
subject: Algarve
subject: Idade do Ferro
subject: Renícios
subject: Indígenas
subject: Colonização

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Os trabalhos arqueológicas realizados no Algarve durante a última década permitiram recolher um importante conjunto de dados sobre a ocupação da Idade do Ferro desta região. Discutem-se esses dados, não se perdendo de vista o contexto do Sudoeste peninsular em que a área analisada se insere. Tornou-se claro que a ocupação sidérica do Extremo Sul de Portugal está intimamente relacionada com mundo mediterrâneo e, numa primeira fase, com a instalação de populações orientais na região do Estreito de Gibraltar. Mas essa primeira fase parece ter ocorrido apenas nos sítios do Algarve Oriental (Castro Marim e Tavira), tendo a área ocidental ficado à margem desse movimento orientalizante. Em meados do século V a. C., a Idade do Ferro, ainda de matriz mediterrânea, está já documentada nos sítios ocidentais (Faro, Cerro da Rocha Branca, Monte Molião), sendo também este o momento em que em Castro Marim se observam mudanças significativas quer ao nível da orientação das estruturas construídas, quer no que diz respeito à origem das importações dos produtos alimentares e manufacturados.
title: Tête de rivet à décor en esses (Inv. 2007.38.641.1) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: quincaillerie

description: Tête de rivet à décor en esses.
Relating soil geochemical properties to arsenic bioaccessibility through hierarchical modeling
Creators: name: Nelson, Clay M.
name: Li, Kevin
name: Obenour, Daniel R.
name: Miller, Jonathan
name: Misenheimer, John C.
name: Scheckel, Kirk
name: Betts, Aaron
name: Juhasz, Albert
name: Thomas, David J.
name: Bradham, Karen D.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Interest in improved understanding of relationships among soil properties and arsenic (As) bioaccessibility has motivated the use of regression models for As bioaccessibility prediction. However, limits in the numbers and types of soils included in previous studies restrict the usefulness of these models beyond the range of soil conditions evaluated, as evidenced by reduced predictive performance when applied to new data. In response, hierarchical models that consider variability in relationships among soil properties and As bioaccessibility across geographic locations and contaminant sources were developed to predict As bioaccessibility in 139 soils on both a mass fraction (mg/kg) and % basis. The hierarchical approach improved the estimation of As bioaccessibility in studied soils. In addition, the number of soil elements identified as statistically significant explanatory variables increased when compared to previous investigations. Specifically, total soil Fe, P, Ca, Co, and V were significant explanatory variables in both models, while total As, Cd, Cu, Ni, and Zn were also significant in the mass fraction model and Mg was significant in the % model. This developed hierarchical approach provides a novel tool to (1) explore relationships between soil properties and As bioaccessibility across a broad range of soil types and As contaminant sources encountered in the environment and (2) identify areas of future mechanistic research to better understand the complexity of interactions between soil properties and As bioaccessibility.
Additional file 4 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 4: Figure S4. Increased levels of enzymes in AD brain pelletomes. Western blots and quantifications of enzymes identified by proteomics. A) Glucose-6-phosphate isomerase (GPI). B) Creatine kinase B (CKB). C) Low density lipoprotein receptor-related protein (LRP). D) Adenylate cyclase isozyme 1 (ADCY1). E) Calcium/Calmodulin protein kinase 2 (CAMK2). F) Fatty acid synthase (FASN). G) Phosphoglycerate mutase (PGAM). H) Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1). I) KU70. P values are given. Data are presented as mean ± SEM (n = 8/group).
SI-traceable measurement of an optical frequency at low $10^{-16}$ level without a local primary standard
Creators: name: Hachisu, Hidekazu
name: Petit, Gérard
name: Nakagawa, Fumimaru
name: Hanado, Yuko
name: Ido, Tetsuya
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: SI-traceable measurements of optical frequencies using International Atomic Time (TAI) do not require a local primary frequency reference, but suffer from an uncertainty in tracing to the SI second. For the measurement of the $^{87}$Sr lattice clock transition, we have reduced this uncertainty to low $10^{-16}$ level by averaging three sets of ten-day intermittent measurements, in which we operated the lattice clock for $10^4$ s on each day. Moreover, a combined oscillator of two hydrogen masers was employed as a local flywheel oscillator (LFO) in order to mitigate the impact of sporadic excursion of LFO frequency. The resultant absolute frequency with fractional uncertainty of $4.3\times10^{-16}$ agrees with other measurements based on local state-of-the-art cesium fountains.
description: 14 pages, 5 figures
Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors
Creators: name: Yao, Yongfang
name: Huang, Tao
name: Wang, Yuyang
name: Wang, Longfei
name: Feng, Siqi
name: Cheng, Weyland
name: Yang, Longhua
name: Duan, Yongtao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: The screened compound DYT-1 from our in-house library was taken as a lead (inhibiting tubulin polymerisation: IC50=25.6 µM, anti-angiogenesis in Zebrafish: IC50=38.4 µM, anti-proliferation against K562 and Jurkat: IC50=6.2 and 7.9 µM, respectively). Further investigation of medicinal chemistry conditions yielded compound 29e (inhibiting tubulin polymerisation: IC50=4.8 µM and anti-angiogenesis in Zebrafish: IC50=3.6 µM) based on tubulin and zebrafish assays, which displayed noteworthily nanomolar potency against a variety of leukaemia cell lines (IC50= 0.09–1.22 µM), especially K562 cells where apoptosis was induced. Molecular docking, molecular dynamics (MD) simulation, radioligand binding assay and cellular microtubule networks disruption results showed that 29e stably binds to the tubulin colchicine site. 29e significantly inhibited HUVEC tube formation, migration and invasion in vitro. Anti-angiogenesis in vivo was confirmed by zebrafish xenograft. 29e also prominently blocked K562 cell proliferation and metastasis in blood vessels and surrounding tissues of the zebrafish xenograft model. Together with promising physicochemical property and metabolic stability, 29e could be considered an effective anti-angiogenesis and -leukaemia drug candidate that binds to the tubulin colchicine site.
The effect of electric-field-induced alignment on the electrical mobility of fractal aggregates
Creators: name: Corson, James
name: Mulholland, George W.
name: Zachariah, Michael R.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Biotechnology

description: We study the effects of electric field strength on the mobility of soot-like fractal aggregates (fractal dimension of 1.78). The probability distribution for the particle orientation is governed by the ratio of the interaction energy between the electric field and the induced dipole in the particle to the energy associated with Brownian forces in the surrounding medium. We use our extended Kirkwood–Riseman method to calculate the friction tensor for aggregates of up to 2000 spheres, with primary sphere sizes in the transition and near-free molecule regimes. Our results for electrical mobility versus field strength are in good agreement with published experimental data for soot, which show an increase in mobility on the order of 8% from random to aligned orientations. Our calculations show that particles become aligned at decreasing field strength as particle size increases because particle polarizability increases with volume. Large aggregates are at least partially aligned at field strengths below 1000 V/cm, though a small change in mobility means that alignment is not an issue in many practical applications. However, improved differential mobility analyzers would be required to take advantage of small changes in mobility to provide shape characterization. Copyright © 2018 American Association for Aerosol Research
title: Großrestbestimmungen an Pollenprofilen aus Ambrona (Provinz Soria)
title: Großrestbestimmungen an Pollenprofilen aus Ambrona (Provinz Soria)
titleType: Subtitle
Creators: name: Stika, Hans-Peter
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Großrestanalysen
subject: Würmeiszeit
subject: mittlere und späte Nacheiszeit
subject: Wasserpflanzen
subject: Feuchtvegetation
subject: Nordmeseta
subject: macro-remain analyses
subject: glacial period Würm
subject: middle and late post-glacial period
subject: aquatic plants
subject: moisture vegetation
subject: North Meseta
subject: Análisis de macro-restos vegetales
subject: periodo glacial Würm
subject: periodo post-glacial medio y tardío
subject: plantas acuáticas
subject: vegetación de zonas húmedas
subject: Meseta Norte

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Die Großrestuntersuchungen an Pollenprofilen erbrachten eine lange Artenliste und spiegeln die Vegetationsverhältnisse in der näheren Umgebung der Feuchtsedimente wider. Die nachgewiesenen Taxa geben Auskunft über die Gewässerphase in den Lagunas im Tal von Ambrona und Miño de Medinaceli. Zusammen mit den Ergebnissen der Pollenanalysen und der pflanzlichen Großrestbestimmungen aus neolithischen Siedlungsgrabungen und prähistorischen Grabhügeln kann die Vegetationsentwicklung und der Einfluss der Besiedlung beschrieben werden.
The Effect of Electric Field Induced Alignment on the Electrical Mobility of Fractal Aggregates
Creators: name: Corson, James
name: Mulholland, George W.
name: Zachariah, Michael R.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences

description: We study the effects of electric field strength on the mobility of soot-like fractal aggregates (fractal dimension of 1.78). The probability distribution for the particle orientation is governed by the ratio of the interaction energy between the electric field and the induced dipole in the particle to the energy associated with Brownian forces in the surrounding medium. We use our extended Kirkwood-Riseman method to calculate the friction tensor for aggregates of up to 2000 spheres, with primary sphere sizes in the transition and near free molecule regimes. Our results for electrical mobility versus field strength are in good agreement with published experimental data for soot, which show an increase in mobility on the order of 8% from random to aligned orientations. Our calculations show that particles become aligned at decreasing field strength as particle size increases because particle polarizability increases with volume. Large aggregates are at least partially aligned at field strengths below 1000 V/cm, though the small change in mobility means that alignment is not an issue in many practical applications. However, improved DMAs would be required to take advantage of small changes in mobility to provide shape characterization.
Solving piecewise linear equations in abs-normal form
Creators: name: Griewank, Andreas
name: Bernt, Jens Uwe
name: Radons, Manuel
name: Streubel, Tom
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 90C33, 90C56, 49J52, 65F99

description: With the ultimate goal of iteratively solving piecewise smooth (PS) systems, we consider the solution of piecewise linear (PL) equations. PL models can be derived in the fashion of automatic or algorithmic differentiation as local approximations of PS functions with a second order error in the distance to a given reference point. The resulting PL functions are obtained quite naturally in what we call the abs-normal form, a variant of the state representation proposed by Bokhoven in his dissertation. Apart from the tradition of PL modeling by electrical engineers, which dates back to the Master thesis of Thomas Stern in 1956, we take into account more recent results on linear complementarity problems and semi-smooth equations originating in the optimization community. We analyze simultaneously the original PL problem (OPL) in abs-normal form and a corresponding complementary system (CPL), which is closely related to the absolute value equation (AVE) studied by Mangasarian et al and a corresponding linear complementarity problem (LCP). We show that the CPL, like KKT conditions and other simply switched systems, cannot be open without being injective. Hence some of the intriguing PL structure described by Scholtes is lost in the transformation from OPL to CPL. To both problems one may apply Newton variants with appropriate generalized Jacobians directly computable from the abs-normal representation. Alternatively, the CPL can be solved by Bokhoven's modulus method and related fixed point iterations. We compile the properties of the various schemes and highlight the connection to the properties of the Schur complement matrix, in particular its signed real spectral radius as analyzed by Rump. Numerical experiments and suitable combinations of the fixed point solvers and stabilized generalized Newton variants remain to be realized.
Studies on hydroquinone based maleate bolaamphiphile organogels and their drug formulations
Creators: name: Bijari Anil Kumar
name: Nayak, Rati Ranjan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Now a day’s there is an upsurge in topical gel formulations, they can be prepared by varying physico-chemical methods and provide better localized action. A maleate based symmetric bolaamphiphile was synthesized by using cost-effective starting materials under mild reaction condition. The gelation ability of bolaamphiphile in aqueous medium was examined for a series of organic solvents. In hexane, the gelator showed better gelation ability with relatively higher critical strain (54 Pa) values. Further, the microscopic images of the gel revealed flakes like morphology, both the XRD and DFT studies revealed the presence of non covalent interactions. These gels showed a high internal-phase mole ratio of the topical drugs in the order of curcumin < salicylic acid < Ibuprofen. Formation of aqueous and organic gel-phase formulation may facilitate the topical medications for various applications related to ophthalmic and skin infections.
title: Tête de rivet à décor en esses (Inv. 2007.38.641.1)
Creators: name: Luginbühl, Thierry
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: quincaillerie
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
title: Einblicke in die mittel- bis spätholozäne Vegetationsgeschichte auf der Nordmeseta Spaniens bei Miño de Medinaceli (Provinz Soria). Ergebnisse einer archäopalynologischen Prospektion
title: Einblicke in die mittel- bis spätholozäne Vegetationsgeschichte auf der Nordmeseta Spaniens bei Miño de Medinaceli (Provinz Soria). Ergebnisse einer archäopalynologischen Prospektion
titleType: Subtitle
Creators: name: Schweizer, Astrid
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Pollenanalyse
subject: Pollendiagramm
subject: (Mittel-, Spät-) Holozän
subject: Vegetationsgeschichte
subject: Kiefernwald
subject: anthropogener Einfluss
subject: Ackerbau
subject: Viehhaltung
subject: Palynological analyses
subject: pollen diagram
subject: (Mid-, Late) Holocene
subject: vegetation history
subject: pine forest
subject: anthropogenic influence
subject: arable fields
subject: cattle breeding
subject: Análisis palinológico
subject: diagrama de pólenes
subject: Holoceno medio y tardío
subject: historia de la vegetación
subject: pinares
subject: influencia antrópica
subject: agricultura
subject: ganadería

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Palynologische Prospektionsanalysen auf der spanischen Nordmeseta ergaben Einblicke in die Vegetationsgeschichte des Spätholozäns. Es zeigte sich, dass Kiefern im Untersuchungszeitraum die Vegetation im Arbeitsgebiet deutlich dominierten. Außerdem konnte festgestellt werden, dass trotz der negativen klimatischen Wasserbilanz dieserRegion das Potential für weiterführende umweltanalytische Untersuchungen vorhanden ist.
Additional file 5 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 5: Figure S5. Increased levels of enzymes in MCI brain pelletomes. Western blots and quantifications of enzymes identified by proteomics. A) Glucose-6-phosphate isomerase (GPI). B) Creatine kinase B (CKB). C) Low density lipoprotein receptor-related protein (LRP). D) Adenylate cyclase isozyme 1 (ADCY1). E) Calcium/Calmodulin protein kinase 2 (CAMK2). F) Fatty acid synthase (FASN). G) Phosphoglycerate mutase (PGAM). H) Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1). I) KU70. P values are given. Data are presented as mean ± SEM (n = 10/group).
title: Ein pleniweichselzeitliches Pollenprofil von der spanischen Nordmeseta bei Miño de Medinaceli (Provinz Soria)
title: Ein pleniweichselzeitliches Pollenprofil von der spanischen Nordmeseta bei Miño de Medinaceli (Provinz Soria)
titleType: Subtitle
Creators: name: Schweizer, Astrid
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Pollenanalyse
subject: Pollendiagramm
subject: Pleniweichselzeit
subject: Pleistozän
subject: Vegetationsgeschichte
subject: Klima
subject: Bewaldung
subject: Palynological analysis
subject: pollen diagram
subject: Pleni-Weichselian
subject: Pleistocene
subject: vegetation history
subject: climate
subject: forestation
subject: Análisis palinológico
subject: diagrama de pólenes
subject: Pleistoceno
subject: Pleingular
subject: historia de la vegetación
subject: clima
subject: forestación

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Palynologische Untersuchungen auf der spanischen Nordmeseta gaben Einblicke in die Vegetationsgeschichte des Pleniglazials. Es zeigte sich, dass das Klima auf dieser zentralen Hochfläche offenbar nicht zu Temperaturextremen neigte, die Feuchtigkeitsverhältnisse dagegen sehr sensibel auf großräumige klimatische Veränderungen reagierten. Weiterhin zeigte sich, dass diese Region während des gesamten untersuchten Zeitraums bewaldet gewesen sein muss.
Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails
Creators: name: Han, Seo-Jung
name: Jung, Jae Eun
name: Oh, Do Hee
name: Kim, Minsup
name: Kim, Jae-Min
name: Chung, Kyung-Sook
name: Han, Hee-Soo
name: Lee, Jeong-Hun
name: Lee, Kyung-Tae
name: Jeong, Hee Jin
name: Park, In Ho
name: Jeon, Eunkyeong
name: Shin, Jeon-Soo
name: Hwang, Dongkeun
name: Cho, Art E.
name: Lee, Duck-Hyung
name: Sim, Taebo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity. Kinome-wide selectivity profiling analysis showed that type II kinase inhibitor 7a potently inhibited Lck kinase with great selectivity (IC50 of 23.0 nM). It was found that 7a and its derivatives possessed high selectivity for Lck over even structurally conserved all Src family kinases. We also observed that 7a inhibited Lck activation in Jurkat T cells. Moreover, 7a was found to alleviate clinical symptoms in DSS-induced colitis mice. This study provides a novel insight into the design of selective type II kinase inhibitors by adopting chiral peptidomimetic moieties on the tail region.