cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Classicizing Visions of Constantinople after 1204: Niketas Choniates' De Signis
Creators: name: Spingou, Foteini
Publisher: name: Humanities Commons
Year: 2022

description: The article focuses on one of the most famous accounts of the events of 1204: the De Signis by Niketas Choniates. It demonstrates how Choniates constructed a (semi)fictional account of the assaults against the Byzantine culture and identity through a constellation of symbols and passages drawn from the Greek Classics. The article comprises three sections. In Section 1 (“The De Signis in the LO Version of the Diegesis”, pp. 183–191), I look at the evidence offered by the manuscript record. I argue that (a) The De Signis is a literary appendix to one of the books of a particular version of Niketas Choniates’ History (the LO) and (b) that the LO version represents an unfinished project that Choniates purported to dedicate to the Byzantine emperor. Section 2 (“The De Signis as a Description of the City of Constantine”, pp. 191–204) focuses on the literary evidence from the De Signis. It reveals the narrative choices and strategies employed by Choniates aimed to create a memory landscape comprehensible only to his educated peers. Section 3 (“The Beauty of Helen of Troy”, pp. 204–217) offers a close reading of the crescendo of the account, the ekphrasis of the statue of Helen of Troy. By establishing a close parallel to Isocrates’ Encomium on Helen, it is argued that the statue stands for the beauty of the intellectual life and culture of Constantinople and Choniates’ plea for unity against the ‘illiterate barbarians’ to his fellow literati. The article closes with an appreciation of Choniates’ groundbreaking classicism.
A prática do cantochão na ilha de São Jorge durante o século XVIII: O testemunho das fontes históricas
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2017
Subjects: subject: Musicology
subject: History

description: A prática do cantochão está intimamente ligada à construção das igrejas e consolidação da sua actividade litúrgica, não sendo a ilha de S. Jorge excepção a este percurso litúrgico-musical. Apesar da escassez de fontes musicais que possam comprovar essa actividade, as fontes históricas revelam algumas pistas que permitem uma leitura relativamente abrangente do contexto que circunda a prática do cantochão em S. Jorge. Desta forma, o presente estudo propõe uma visão contextual da prática do cantochão na ilha de São Jorge durante o século XVIII, focando o tipo de estrutura musical que sustentou essa actividade, assim como o seu desenvolvimento e generalização ao longo desse período. Embora incompleta, por via de uma dispersão dos apontamentos históricos por várias fontes, pretende ainda o presente estudo traçar um possível modelo de organização litúrgico-musical na ilha – assente na actividade do clero secular e regular – e a sua adaptação ao contexto local.
Bilateral Patella tendon rupture in young female on Steroid: Case report
Creators: name: Uttar Pradesh, Association
Publisher: name: unknown
Year: 2022
Subjects: subject: Periodicals

description: ABSTRACT
Rupture of bilateral patella tendon has been discussed in case reports. we present a case of young female with bilateral patella tendon rupture with history of oral steroid intake for 10 weeks prior to Injury. She was able to join office job 6 months after surgical repair and intensive rehabilitation.
Despite unclear pathophysiology, use of steroids have been associated with tendon injuries.
description: ABSTRACT Rupture of bilateral patella tendon has been discussed in case reports. we present a case of young female with bilateral patella tendon rupture with history of oral steroid intake for 10 weeks prior to Injury. She was able to join office job 6 months after surgical repair and intensive rehabilitation. Despite unclear pathophysiology, use of steroids have been associated with tendon injuries.
Bilateral Patella tendon rupture in young female on Steroid: Case report
Creators: name: Uttar Pradesh, Association
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Periodicals

description: ABSTRACT Rupture of bilateral patella tendon has been discussed in case reports. we present a case of young female with bilateral patella tendon rupture with history of oral steroid intake for 10 weeks prior to Injury. She was able to join office job 6 months after surgical repair and intensive rehabilitation. Despite unclear pathophysiology, use of steroids have been associated with tendon injuries.
Diáspora: La Influencia Musical Portuguesa en el Mundo
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology
subject: History

description: Programme notes for ensemble Sete Lágrimas's concert in Ávila, during the festival "Abulensis: Festival Internacional de Música" 2012 (www.abulensis.es).
Reevaluating the Mechanistic Insights of α-TOS-Bearing Pt(IV) Anticancer Complexes: A New Perspective from a More In-Depth Knowledge
Creators: name: Marotta, Carlo
name: Cirri, Damiano
name: Funaioli, Tiziana
name: Gabbiani, Chiara
name: Pratesi, Alessandro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: Pt(IV) prodrugs have been extensively studied over the years with the aim of overcoming the limitations of traditional Pt(II) drugs. In this frame, two cisplatin-based Pt(IV) complexes bearing α-tocopherol succinate (α-TOS, a derivative of vitamin E) in the axial position (namely, [PtCl2(NH3)2(OEt)(α-TOS)] and [PtCl2(NH3)2(α-TOS)2] were reported in recent years and their cytotoxicity was evaluated. In particular, [PtCl2(NH3)2(OEt)(α-TOS)] was reported to be more cytotoxic than [PtCl2(NH3)2(α-TOS)2]. In the present comment paper, reasons for the different cytotoxicity of these complexes are discussed in detail and, more in general, a comprehensive elucidation of the mechanism of action of this class of anticancer Pt(IV) compounds is provided. Hopefully, these findings and the resulting improved knowledge of these drugs will help researchers design new and improved Pt(IV) anticancer drugs.
Additional file 1 of Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data
Creators: name: Che, Bizhong
name: Zhong, Chongke
name: Zhang, Ruijie
name: Pu, Liyuan
name: Zhao, Tian
name: Zhang, Yonghong
name: Han, Liyuan
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Hematology

description: Additional file 1: Table S1. Characteristics of the study population according to the TG/HDL-C ratio quartiles. TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate. aContinuous variables are expressed as mean (SD). Categorical variables are expressed as frequency (percentage). Table S2. Correlations of the TyG index and TG/HDL-C ratio with participant characteristicsa. TyG, triglyceride-glucose; TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate. aPoint-biserial correlation for dichotomized variables and Pearson’s correlation for continuous variables. Table S3. Characteristics and cardiovascular outcomes of the study population in England, Scotland, and Wales. TyG, triglyceride-glucose; TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate. aContinuous variables are expressed as mean (SD). Categorical variables are expressed as frequency (percentage). Table S4. Sensitivity analysis: Multivariable-adjusted hazard ratios of cardiovascular disease associated with the TyG index and TG/HDL-C ratio, additionally adjusted for prevalent dyslipidemia, type 2 diabetes, and hypertension. TyG, triglyceride-glucose; TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; HR, hazard ratio. aHazard ratios were adjusted for the variables included in model 3 in Table 2 in addition to prevalent type 2 diabetes, hypertension, and dyslipidemia. Table S5. Sensitivity analysis: Associations of the TyG index and TG/HDL-C ratio with risk of cardiovascular disease, excluding 6080 incident cases with less than 3 years of follow-up (N = 397,255). TyG, triglyceride-glucose; TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; HR, hazard ratio. Hazard ratios were adjusted for the same variables included in model 3 in Table 2. Appendix S1. ICD-10 codes used to ascertain comorbidities and cardiovascular outcomes.
Post-questionnaire – Supplemental material for The effectiveness of self-advocacy videos to inform enablers about the support needs of students with vision impairment
Creators: name: Swain, Gaby
name: Waddington, Jonathan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160512 Social Policy
subject: FOS: Political science
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, Post-questionnaire for The effectiveness of self-advocacy videos to inform enablers about the support needs of students with vision impairment by Gaby Swain and Jonathan Waddington in The British Journal of Visual Impairment
Bilateral Patella tendon rupture in young female on Steroid: Case report
Creators: name: Pandey, Dr Vinay
name: Pandey, Dr Vinay
Publisher: name: Humanities Commons
Year: 2022

description: ABSTRACT Rupture of bilateral patella tendon has been discussed in case reports. we present a case of young female with bilateral patella tendon rupture with history of oral steroid intake for 10 weeks prior to Injury. She was able to join office job 6 months after surgical repair and intensive rehabilitation. Despite unclear pathophysiology, use of steroids have been associated with tendon injuries.
Estêvão Lopes Morago: Responsórios de Natal
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology

description: Preview of Estêvão Lopes Morago's (c.1575-c.1630) Christmas responsories, all for SATB (with verses for 3vv.). Polyphonia 6 ISMN 979-0-9007510-6-5 Work is fully available at http://mpmp.pt/produto/polyphonia-6-estevao-lopes-morago-responsorios-de-natal/
Is the Trans-Influence the Same Quantitative Effect of Two Metal-Ligand Bonds on the Strength of Each Other?
Creators: name: Sadegh, Salehzadeh
name: Movafagh, Samaneh Sanei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Herein, we want to show that the value of the intrinsic trans-influence of two trans ligands, can be calculated on the basis of the concept of the cooperativity of bonds. Two types of trans-influence, including a “quantitative trans-influence” (QTI) and a “relative trans-influence” (RTI) were defined for two trans ligands in one metal complex. Then the trans-influence was evaluated in a series of gold(I) complexes of the type [LAuCO]+/0, and also several square planar complexes of the type [LPtCl3]–/0. Four types of quantitative trans-influence were calculated as QTIν, QTId, QTIBDE and QTIIE based on the quantitative impact of a ligand on the value of vibrational stretching frequency, bond distance, bond dissociation energy, and interaction energy, respectively, of a metal-ligand bond trans to it. Interestingly, the QTIBDE and QTIIE values for the CO molecule in [LAuCO]+/0 complexes, and those for Cl– anion in [LPtCl3]–/0 complexes, are always equal to those of the corresponding trans ligand L. However, in each metal complex, the relative trans-influence of two trans ligands can be quite different.
Música na Sé Catedral de Angra
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology
subject: History

description: A Sé de Angra do Heroísmo possui um vasto arquivo musical, que compreende na sua maioria música sacra do final do século XVIII e XIX. Algumas obras, como as "Matinas para a Sagração da Sé de Angra", do compositor português João José Baldi, e a Missa Concertada pelo Rei D. Pedro IV estão entre estes tesouros únicos da música portuguesa do século XIX. Simultaneamente, encontram-se também obras de compositores locais, que desempenharam funções na Sé, como é o caso de Mateus Pereira de Lacerda e Pedro Machado de Alcântara.
फारवर्ड प्रेस: आइए चलें नई यात्रा की ओर
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Journalism and literature
subject: Journalism and social justice
subject: Indian press
subject: Journalistic ethics
subject: Minorities in journalism
subject: Caste
subject: Little magazines
subject: Periodicals

description: फारवर्ड प्रेस काअंतिम प्रिट अंक अप्रैल, 2016 में प्रकाशित हुआ था। यह उस अंतिम अंक का प्रमोद रंजन द्वारा लिखा गया संपादकीय है। उसके बाद फारवर्ड प्रेस वेबसाइट के रूप में प्रकाशित होता रहा तथा किताबों के व्यवसाय में भी उतरा। फारवर्ड प्रेस के मालिकों द्वारा की जा रही वित्तीय अनियमितता के विरोध में प्रमोद रंजन ने अक्टूबर, 2019 में इस पत्रिका से अलग हो गए।
फारवर्ड प्रेस: आइए चलें नई यात्रा की ओर
Creators: name: Ranjan, Pramod
Publisher: name: unknown
Year: 2022
Subjects: subject: Journalism and social justice
subject: Periodicals
subject: Indian press
subject: Journalism and literature
subject: Minorities in journalism
subject: Caste
subject: Journalistic ethics
subject: Little magazines

description: फारवर्ड प्रेस काअंतिम प्रिट अंक अप्रैल, 2016 में प्रकाशित हुआ था। यह उस अंतिम अंक का प्रमोद रंजन द्वारा लिखा गया संपादकीय है। उसके बाद फारवर्ड प्रेस वेबसाइट के रूप में प्रकाशित होता रहा तथा किताबों के व्यवसाय में भी उतरा। फारवर्ड प्रेस के मालिकों द्वारा की जा रही वित्तीय अनियमितता के विरोध में प्रमोद रंजन ने अक्टूबर, 2019 में इस पत्रिका से अलग हो गए।
Forward Press: Let's embark on a new journey
Creators: name: Ranjan, Pramod
Publisher: name: unknown
Year: 2022
Subjects: subject: Journalism--Objectivity
subject: Journalism and social justice
subject: Hindi literature
subject: Periodicals
subject: Journalistic ethics
subject: Freedom of expression

description: The last print issue of FORWARD Press was published in April, 2016. This editorial in the last issue of Forward Press has been written by Pramod Ranjan. Thereafter Forward Press continued to be published as a website and also ventured into the business of books. Pramod Ranjan parted ways with Forward Press in October 2019 in protest against the financial irregularities being committed by the owners of Forward Press.
MPEC 2025-F40 : COMET P/2016 P5 (COIAS)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET P/2016 P5 (COIAS)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Diogo Dias Melgaz: Honora patrem et matrem; Qui autem biberit ex aqua; Ego sum resurrection
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology

description: Preview of the edition of Portuguese composer Diogo Dias Melgaz's (1638-1700) motets "Honora patrem et matrem", "Qui autem biberit ex aqua" and "Ego sum resurrectio" for four voices (SATB). Polyphonia 7 ISMN 979-0-9007510-7-2 Work is fully available at http://mpmp.pt/produto/polyphonia-7-melgaz-honora-patrem-et-matrem-qui-autem-biberit-ex-aqua-ego-sum-resurrectio/
Additional file 1 of Production of highly pure R,R-2,3-butanediol for biological plant growth promoting agent using carbon feeding control of Paenibacillus polymyxa MDBDO
Creators: name: Ju, Jung-Hyun
name: Jo, Min-Ho
name: Heo, Sun-Yeon
name: Kim, Min-Soo
name: Kim, Chul-Ho
name: Paul, Narayan Chandra
name: Sang, Hyunkyu
name: Oh, Baek-Rock
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Additional file 1: Table S1. Comparison of production and optical purity of R,R-2,3-butanediol by various Paenibacillus strains.
Recent Progress on Core-Shell Zeolitic Imidazole Frameworks: A Review of Synthesis and Applications
Creators: name: Anbari, Alireza Pourvahabi
name: Delcheh, Shima Rahmdel
name: Kashif, Muhammad
name: Ranjbari, Alireza
name: Akbari, Mohammad Karbalaei
name: Heynderickx, Philippe M.
name: Amini, Mojtaba
name: Zhuiykov, Serge
name: Verpoort, Francis
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: Zeolitic Imidazole Frameworks (ZIFs) have recently appeared as a new class of nonporous materials featuring notable physicochemical properties. In particular, ZIFs with core-shell structures have drawn a great deal of attention from research communities owing to their unique features, including superior specific surface area, high porosity content, extraordinary thermal, chemical, and structural stability, feasible synthesis conditions in a mild reaction, and facile growth on external surfaces of core nanostructures. This growth facilitates the synthesis of core/shell hybrid materials, which contain both organic (2-MIM) and inorganic (metal nodes) groups. As a structural advantage, the core/shell configuration favorably promotes the potential implementation of ZIFs in various functional fields, e.g. catalysis, drug delivery, adsorption, separation, and purification applications. The current review investigates recent advances in synthesizing and applying ZIFs with core-shell structures. This research review is divided into four parts. The first part overviews synthesis methods for ZIFs and discusses these nanostructures’ structural and material characteristics. The second part summarizes recent achievements and findings on synthesizing different types of ZIFs featuring core-shell structures. In the third part, potential applications of these novel nanostructured materials are presented, and their features are summarized in the final part.
Forward Press: Let’s embark on a new journey
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Periodicals
subject: Hindi literature
subject: Journalistic ethics
subject: Journalism and social justice
subject: Journalism--Objectivity
subject: Freedom of expression

description: The last print issue of FORWARD Press was published in April, 2016. This editorial in the last issue of Forward Press has been written by Pramod Ranjan. Thereafter Forward Press continued to be published as a website and also ventured into the business of books. Pramod Ranjan parted ways with Forward Press in October 2019 in protest against the financial irregularities being committed by the owners of Forward Press.
sj-pdf-1-asu-10.1177_0003134820949520 - Supplemental material for Theodor Billroth: Surgeon, Musician, and Composer
Creators: name: Lin, Tami Yu-Yu
name: Seal, Andrew
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-asu-10.1177_0003134820949520, for Theodor Billroth: Surgeon, Musician, and Composer by Tami Yu-Yu Lin and Andrew Seal in The American Surgeon
Supplementary Material 1 - Supplemental material for Theodor Billroth: Surgeon, Musician, and Composer
Creators: name: Lin, Tami Yu-Yu
name: Seal, Andrew
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, Supplementary Material 1, for Theodor Billroth: Surgeon, Musician, and Composer by Tami Yu-Yu Lin and Andrew Seal in The American Surgeon
title: ÐÐ¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ñ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð´ÐµÑÐ°Ð»Ð¸ Â«Ð ÑÑÐ°Ð³Â» Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð³Ð¾ÑÑÑÐµÐ¹ ÑÑÐ°Ð¼Ð¿Ð¾Ð²ÐºÐ¸ Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð¾ÑÐ½Ð°ÑÑÐºÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Optimization of the design of the lever part and development of hot stamping technology with the design of technological equipment
Creators: name: Ð¡Ð°Ð²ÐµÐ»ÑÐµÐ², ÐÐ¸ÑÐ°Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¨ÑÐ°Ð¼Ð¿Ð¾Ð²ÐºÐ° Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð² Ð³Ð¾ÑÑÑÐ°Ñ
ÐÐµÑÐ°Ð»Ð¸ Ð¼Ð°ÑÐ¸Ð½
Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ñ
Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÑÑÐ°Ð³
optimization
modeling
lever

description: ÐÐ°Ð½Ð½Ð°Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð´ÐµÑÐ°Ð»Ð¸ Â«Ð ÑÑÐ°Ð³Â» Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸Ð¸, ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ñ Ð¼Ð°ÑÑÑ Ð¸ Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐ¸Ð¼ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿ÑÐ¾ÑÐµÑÑÐ° ÑÑÐ°Ð¼Ð¿Ð¾Ð²ÐºÐ¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¿ÑÐ¾ÑÐµÑÑ Ð´ÐµÑÐ°Ð»Ð¸ Â«Ð ÑÑÐ°Ð³Â» Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ ÑÐ¾Ð¿Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ð¸. Ð¡Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½ Ð¿ÑÐ¾ÑÐµÑÑ ÑÐ¾ÑÐ¼Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´ÐµÑÐ°Ð»Ð¸, Ð²ÑÐ±ÑÐ°Ð½Ð¾ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ðµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð´Ð»Ñ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð¹, Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¼ÐµÑÑ Ð¿Ð¾ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ð¸ Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð´ÐµÑÐ°Ð»Ð¸ Â«Ð ÑÑÐ°Ð³Â».
description: This final qualification work is devoted to the development of the technological process of the Lever part using geometry optimization, weight reduction and further modeling of the stamping process. As a result of the work, the technological process of the Lever part was designed using topological optimization. The process of forming the part is modeled, the necessary equipment for performing technological operations is selected, measures for automating the manufacture of the Lever part are proposed.
A Reforma Tridentina e a música no silêncio claustral: O mosteiro de S. Bento de Cástris
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2015
Subjects: subject: Musicology
subject: History

description: A cidade de Évora foi um importante centro musical durante os séculos XVI e XVII. Para além da prática musical associada à sua Catedral, também outras instituições religiosas mantiveram uma actividade musical regular como é o caso do mosteiro de S. Bento de Cástris - o mosteiro na região de Évora em que sobreviveram mais fontes musicais, desde livros de coro do século XVI a obras de compositores do século XIX.
महामारी के दौर में डॉक्टरों की भूमिका, सीमाएं और प्रोटोकॉल के कुछ सवाल
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Medical policy
subject: Pandemics
subject: COVID-19 (Disease) in mass media
subject: Medical protocols
subject: COVID-19 (Disease)--Government policy
subject: International statistical classification of diseases and related health problems

description: अधिकांश लोग समझते हैं कि चिकित्सक ही जांच द्वारा तय करते हैं कि किसे कोविड है और किसे नहीं तथा अगर किसी की मौत होती है तो चिकित्सक ही यह तय करते हैं कि वह मृत्यु कोविड से हुई है या किसी अन्य कारण से। इसलिए जब कोई खुद को चिकित्सक बताता है या अपने परिवार में चिकित्सकों के होने का ज़िक्र करता है तो लोग उसकी बात पर अनिवार्य रूप से विश्वास करते हैं, लेकिन कोविड के मामले में वस्तुस्थिति कुछ और है। इस लेख में  कोविड 19 के दौरान डॉक्टरों के लिए निर्धारित प्रोटोकॉल से होने वाली गड़बड़ियों की चर्चा की गई है।  कोविड से हुई मौत के निर्धारण में भी चिकित्सक की भूमिका एकदम शाब्दिक अर्थ में रबर स्टैंप की तरह है। कोविड से हुई मौतों के निर्धारण के लिए भारत समेत दुनिया के अधिकांश देशों में विश्व स्वास्थ्य संगठन द्वारा विकसित एक विशेष कोड का इस्तेमाल किया जा रहा है, जिसमें सिर्फ़ मृतक का लक्षण, जांच रिपोर्ट आदि भरनी होती है और उस कोड के अनुसार ही निर्धारित करना होता है कि मौत का मुख्य कारण किस बीमारी को बताया जाना है। अगर किसी व्यक्ति की कोविड की टेस्ट-रिपोर्ट पॉज़िटिव आई है तो चाहे किसी भी कारण से[v] उसकी मौत हुई हो, उस कोड के अनुसार उसे कोविड से हुई मौत के रूप में ही गिना जाएगा। यहाँ तक कि भले ही कोविड की जांच भी न हुई हो, रिपोर्ट अस्पष्ट या निगेटिव आयी हो, लेकिन अगर उसमें ऐसे कोई भी लक्षण मौजूद हों, जो कोविड के लक्षणों से मिलते जुलते हों, जैसे- खांसी, सर्दी, ज़ुकाम, साँस लेने में तकलीफ़, तो उसे उस कोड के अनुसार उसकी मौत को कोविड से हुई मौत के रूप में दर्ज किया जाना है।
Estêvão Lopes Morago: De profundis clamavi, Oculi mei semper ad Dominum, Versa est in luctum
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology

description: Preview of the edition of Estêvão Lopes Morago's (c.1575-c.1630) motets "De profundis clamavi", "Oculi mei semper ad Dominum" and "Versa est in luctum", for four voices (SATB). Polyphonia 8 ISMN 979-0-9007510-8-9. Work is fully available at http://mpmp.pt/produto/polyphonia-8-lopes-morago-de-profundis-clamavi-oculi-mei-semper-ad-dominum-versa-est-in-luctum/
Anacardium microcarpum extract and fractions protect against paraquat-induced toxicity in Drosophila melanogaster
Creators: name: Müller, Katiane Raquel
name: Martins, Illana Kemmerich
name: Rodrigues, Nathane Rosa
name: Da Cruz, Litiele Cezar
name: Barbosa Filho, Valter Menezes
name: Macedo, Giulianna Echeverria
name: Da Silva, Gustavo Felipe
name: Kamdem, Jean Paul
name: De Menezes, Irwin Rose Alencar
name: Franco, Jeferson Luis
name: Posser, Thaís
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: cajuí
Drosophila melanogaster
antioxidant
neuroprotection
herbicide

description: Anacardium microcarpum Ducke (Anacardiaceae) is a native species of Brazil used in folk medicine for the treatment of several illnesses although its antioxidant activity has been reported in vitro, there is no evidence of this effect in an in vivo model. Here, we investigated the potential protective effect of hydroalcoholic extract (AMHE), methanol (AMMF) and acetate (AMAF) fraction of A. microcarpum against paraquat toxicity on survivorship, locomotor performance, antioxidant enzymes activity and reactive species using Drosophila melanogaster. Flies were exposed to the extract or fractions (1 and 10 mg/ml) in the presence or absence of paraquat (5 mM) in sucrose solution for 72 h. In addition, total phenolic content of extract and fractions was evaluated as well as ABTS radical scavenging capacity. Our results demonstrated that AMAF presented higher content of phenols and ABTS chelating potential. Treatment of flies with the extract or fractions did not alter the survivorship, locomotor ability, and acetylcholinesterase (AchE) activity per se. Paraquat caused 85 % mortality of flies and 30 % increase in reactive species generation, which were significantly attenuated by AMHE and AMMF. AAMF increased catalase activity (from 66.77 ± 6.64 to 223.94 ± 25.92 mU/mg of protein), while AMAF increased GST activity (from 477.76 ± 92 to 770.19 ± 147.92 mU/mg of protein) and catalase activity (from 66.77 ± 6.64 to 220.54 ± 26.63 mU/mg of protein). AMHE and AMMF were more effective in protecting against paraquat toxicity. Taken together, the data indicate the potential of this plant in acting as a protective and antioxidant agent in vivo.
description: EXCLI Journal; 16:Doc302; ISSN 1611-2156
Covid-19: Role and limitations of doctors and treatment protocols
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Medical ethics
subject: Medical informatics
subject: Medical policy
subject: Medical economics
subject: Medical laws and legislation
subject: International statistical classification of diseases and related health problems
subject: World Health Organization
subject: COVID-19 (Disease) in mass media

description: As was expected, the country is witnessing an explosion of Covid cases, leading to chaos and mayhem. People are dying for want of oxygen. The protocol for the treatment of Covid patients is faulty and that is one reason for the high number of deaths. Thanks to the protocol, deaths due to other causes are also being added to the Covid toll. In this article, we would try to look at the connections between the Covid pandemic and the doctors. So far, the discussion on the role of the doctors, which is decidedly very important, has largely been one-sided.  hydroxychloroquine controversy was not limited to this spat between India and Trump. The kind of charges and countercharges related to this drug during the Covid pandemic amply demonstrate that for the forces which hoped to benefit by its growing demand, human lives were just numbers.
साहित्य का नया रास्ता
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Hindi literature
subject: Progressivism in literature
subject: Book reviews
subject: Hindi poetry
subject: Literature and society
subject: Literature

description: दिनों-दिन उपन्यास और कहानियां “पढ़ना” कठिन होता जा रहा है। साहित्य संबंधी लेखन-अध्यापन में लगे हम लोगों को पढ़ने काम अक्सर एक पेशागत काम की तरह करना पड़ता है। ऐसा साहित्य हिंदी में बहुत कम आ भी रहा है जिसे पढ़ कर बहुत कुछ नया मिलने की उम्मीद जगे। वस्तुत: बात सिर्फ हिंदी की नहीं है, परंपरागत रूप से जिसे हम विशुद्ध साहित्य कहते हैं, वह अब अपने समय की संवेदना, तेजी से बदलते यथार्थ और उपभोक्ता की जरूरतों की नब्ज पकड़ने में सफल नहीं हो रहा। ऐसा क्यों है? लेखक पिछड़ गए हैं या प्रिंट नामक वह माध्यम पुराना पड़ गया है जिसमें हम पिछले लगभग छह सौ सालों से साहित्य को प्रसारित करने के आदी रहे हैं? या फिर ‘साहित्य’ ही अप्रासंगिक हो गया है? संभवत: संकट दुहरा है। एक ओर प्रिंट माध्यम में काम करने वाले लेखक अपने समय से पिछड़े हुए हैं, दूसरी ओर यह माध्यम भी पुराना पड़ गया है।  साहित्य एक नए रास्ते पर चल पड़ा है। प्रिंट की एकरसता की जगह वह बहुआयामी माध्यमों के बीच निर्मित-प्रसारित हो रहा है और करोड़ो-करोड़ लोग उसके साथ चल रहे हैं, लेकिन पारंपरिक आलोचकगण पीछे छूट गए हैं। साहित्य के प्रसारण के नए माध्यमों को, इसके नए-नए रूपों को, इसके मूल्यों के नए वाहकों को वे रेखांकित नहीं कर पा रहे हैं। इसलिए ऐसा प्रतीत होता है कि साहित्य को पसंद करने वाले लोग बहुत कम हो गए हैं।
Vicente Lusitano: Regina Caeli
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2012
Subjects: subject: Musicology

description: Preview of the edition of Portuguese composer Vicente Lusitano's (fl. c.1500-c.1555) motete "Regina Caeli" for five voices (SSATB). Polyphonia 9 ISMN 979-0-9007510-0-3 Work is fully available at http://mpmp.pt/produto/polyphonia-9-vicente-lusitano-regina-caeli/
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)
Creators: name: Shaikh, Shafiq
name: Zhao, Xia
name: Wagner, Ryan T.
name: Pan, Xiaoyu
name: Hlady, Ryan A.
name: Wang, Liguo
name: Ho, Thai H.
name: Robertson, Keith D.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology
subject: Computational Biology

description: RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of VHL followed by mutations in epigenetic regulators PBRM1, SETD2, and BAP1. Mutations in SETD2, a histone H3 lysine 36 trimethylase (H3K36me3), are associated with reduced survival, greater metastatic propensity, and metabolic reprogramming. While m6A and H3K36me3 deregulation are separately implicated in renal tumorigenesis, H3K36me3 may participate directly in m6A targeting, but the m6A-H3K36me3 interplay has not been investigated in the context of ccRCC. Using RCC-relevant SETD2 isogenic knockout and rescue cell line models, we demonstrate a dynamic redistribution of m6A in the SETD2 depleted transcriptome, with a subset of transcripts involved in metabolic reprogramming demonstrating SETD2 dependent m6A and expression level changes. Using a panel of six histone modifications we show that m6A redistributes to regions enriched in gained active enhancers upon SETD2 inactivation. Finally, we demonstrate a reversal of transcriptomic programs involved in SETD2 loss mediated metabolic reprogramming, and reduced cell viability through pharmacologic inhibition or genetic ablation of m6A writer METTL3 specific to SETD2 deficient cells. Thus, targeting m6A may represent a novel therapeutic vulnerability in SETD2 mutant ccRCC.
The usages of JOIN2 authority records
Creators: name: Thiele, Robert
name: Große, Katrin
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017

description: 4th Invenio User Group Workshop, IUGW2017, Garching, Heinz Maier-Leibnitz Zentrum, Germany, 21 Mar 2017 - 24 Mar 2017
description: An important base of the common JOIN2 repository infrastructure of DESY, DKFZ, FZJ, GSI, MLZ and RWTH Aachen are about 134 000 authority records for grants, projects, large-scale infrastructures, cooperations, journals, and different kinds of keys. All instances are using the authorities together. We will present how these authority data are used for different purposes e.g. the recent and upcoming obligations to report to regard to our funding and the data export to openAire. Furthermore, we discuss this in dependence to the German “Kerndatensatz Forschung”, which will be the new standard for future.
Moses in Rabbinic Literature (Encyclopedia of the Bible and Its Reception)
Creators: name: Miller, Yonatan
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Rabbinical literature
subject: Moses (Biblical leader)
subject: Moses (Biblical leader) in rabbinical literature
subject: Biblical interpretation

description: An overview of rabbinic traditions about Moses, with attention to the absence of the hagiographic traditions typical of earlier and later Jewish literature.
The technology landscape for detection of DNA methylation in cancer liquid biopsies
Creators: name: Neefs, Isabelle
name: Ibrahim, Joe
name: Peeters, Marc
name: Van Camp, Guy
name: de Beeck, Ken Op
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: DNA methylation is a well-studied epigenetic factor and has become a powerful player in the cancer biomarker research field. Together with the rising interest in methylation biomarkers, the technological advances for the detection of DNA methylation have been immense. This has led to a plethora of different methods. The first methods were established for DNA methylation detection in genomic DNA, while new methods have focused more on compatibility with the emerging interest of cell-free DNA (cfDNA) from liquid biopsies. As DNA methylation detection in cfDNA brings its own challenges, a shift from the gold standard bisulfite conversion towards enzymatic conversion methods can be observed in recent years. In this review, we aim to summarize the classic and more recent DNA methylation detection methods for liquid biopsies. Importantly, the few existing European Certified In Vitro Diagnostics (CE-IVD) clinical applications for liquid biopsies are also described, underlining the potential of DNA methylation as a detection biomarker in cfDNA. Furthermore, we provide some insights into how the field might evolve in the future, where we believe enzymatic conversion might become a new gold standard and direct sequencing methods, such as ONT-sequencing, will get an important place in the epigenetic research field. Lastly, we believe that multi-omics technologies, which can combine diverse types of biomarkers, will most likely become more important in future clinical applications. Moreover, novel recent technologies are being developed and show promising clinical applications. Taken together, methylation biomarkers are becoming more important for clinical implementation.
Moses in Rabbinic Literature (Encyclopedia of the Bible and Its Reception)
Creators: name: Miller, Yonatan
Publisher: name: unknown
Year: 2022
Subjects: subject: Moses (Biblical leader)
subject: Moses (Biblical leader) in rabbinical literature
subject: Rabbinical literature
subject: Biblical interpretation

description: An overview of rabbinic traditions about Moses, with attention to the absence of the hagiographic traditions typical of earlier and later Jewish literature.
D. João IV: Anima mea turbata est
Creators: name: Henriques, Luís
Publisher: name: unknown
Year: 2015
Subjects: subject: Musicology

description: Edition of the two surviving parts - the altus secundus and bassus - of King D. João IV's motet "Anima mea turbata est" for six voices. The "altus secundus" of the motet is found in the "altus secundi chori" part-book ff. 57-58 and the "bassus" in the "bassus secundi chori" part-book ff. 57-58 of João Lourenço Rebelo's "Psalmi tum Vesperarum, tum Completorii" (Rome, 1657).
'दोआबा' का अहिल्या आख्यान और साहित्य की कसौटी
Creators: name: Ranjan, Pramod
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Feminist literary criticism
subject: Little magazines
subject: Book reviewing
subject: Hindi literature
subject: Novelists, Hindi
subject: Progressivism in literature
subject: Literature and society
subject: Caste
subject: Sociology--Research
subject: Man-woman relationships

description: पटना से प्रकाशित दोआबा  के जनवरी-मार्च, 2022 अंक की समीक्षा है। दोआबा का यह अंक लगभग 600 पन्नों का है। इनमें से 533 पन्नों में नीलम नील की दो ‘कथा-डायरी’ प्रकाशित हैं, जिनके शीर्षक क्रमश: ‘आंगन में आग’ और ‘अहिल्या आख्यान’ हैं। शेष पृष्ठों पर उन्हीं पर केंद्रित संपादकीय, संस्मरण आदि हैं। साहित्य की पहचान यह नहीं है कि लेखक कितना संवेदनशील है, उसकी भाषा कितनी तरल है या वह अपने लेखन से पाठक को भावुक करने में  कितना सफल  है। बल्कि यह देखा जाना चाहिए कि उस साहित्य से पाठक किन मूल्यों के प्रति संवेदनशील और जागरूक हो रहा है। इस कसौटी पर नीलम नील की कथा-डायरी खरी नहीं उतरती।  पटना से प्रकाशित दोआबा जनवरी-मार्च, 2022 के अंक लगभग 600 पन्नों का था। इनमें से 533 पन्नों में नीलम नील की दो ‘कथा-डायरी’ प्रकाशित हुई थी, जिनके शीर्षक क्रमश: ‘आंगन में आग’ और ‘अहिल्या आख्यान’ थे। शेष पृष्ठों पर उन्हीं पर केंद्रित संपादकीय, संस्मरण आदि हैं। यह उसी की समीक्षा है। यह समीक्षा साहित्यिक वेबसाइट जानकीपुल में 30 जनवरी, 2022 को प्रकाशित हुई थी।
Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress
Creators: name: Champroux, Alexandre
name: Sadat-Shirazi, Mitra
name: Chen, Xuan
name: Hacker, Jonathan
name: Yang, Yongjie
name: Feig, Larry A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce stress-specific phenotypes in their offspring. However, how each stress paradigm alters the levels of distinct sets of sperm miRNAs is not known. We showed previously that exposure of male mice to chronic social instability (CSI) stress results in elevated anxiety and reduced sociability specifically in their female offspring across multiple generations because it reduces miR-34c levels in sperm of stressed males and their unstressed male offspring. Here, we describe evidence that astrocyte-derived exosomes (A-Exos) carrying miR-34c mediate how CSI stress has this transgenerational effect on sperm. We found that CSI stress decreases miR-34c carried by A-Exos in the prefrontal cortex and amygdala, as well as in the blood of males. Importantly, miR-34c A-Exos levels are also reduced in these tissues in their F1 male offspring, who despite not being exposed to stress, exhibit reduced sperm miR-34c levels and transmit the same stress-associated traits to their male and female offspring. Furthermore, restoring A-Exos miR-34c content in the blood of CSI-stressed males by intravenous injection of miR-34c-containing A-Exos restores miR-34c levels in their sperm. These findings reveal an unexpected role for A-Exos in maintaining sperm miR-34c levels by a process that when suppressed by CSI stress mediates this example of transgenerational epigenetic inheritance.
DNA-based cell typing in menstrual effluent identifies cell type variation by sample collection method: toward noninvasive biomarker development for women’s health
Creators: name: Vlasac, Irma M.
name: Stolrow, Hannah G.
name: Thayer, Zaneta M.
name: Christensen, Brock C.
name: Rivera, Luisa
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Menstrual effluent cell profiles have potential as noninvasive biomarkers of female reproductive and gynecological health and disease. We used DNA methylation-based cell type deconvolution (methylation cytometry) to identify cell type profiles in self-collected menstrual effluent. During the second day of their menstrual cycle, healthy participants collected menstrual effluent using a vaginal swab, menstrual cup, and pad. Immune cell proportions were highest in menstrual cup samples, and epithelial cells were highest in swab samples. Our work demonstrates the feasibility and utility of menstrual effluent cell profiling in population-level research using remotely collected samples and DNA methylation.
Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults
Creators: name: Lin, Lisha
name: Zhao, Wei
name: Li, Zheng
name: Ratliff, Scott M.
name: Wang, Yi Zhe
name: Mitchell, Colter
name: Faul, Jessica D.
name: Kardia, Sharon L. R.
name: Birditt, Kira S.
name: Smith, Jennifer A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Poly-epigenetic scores (PEGS) are surrogate measures that help capture individual-level risk. Understanding how the associations between PEGS and cardiometabolic risk factors vary by demographics and health behaviors is crucial for lowering the burden of cardiometabolic diseases. We used results from established epigenome-wide association studies to construct trait-specific PEGS from whole blood DNA methylation for systolic and diastolic blood pressure (SBP, DBP), body mass index (BMI), C-reactive protein (CRP), high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglycerides (TG), and fasting glucose. Overall and race-stratified associations between PEGS and corresponding traits were examined in adults >50 years from the Health and Retirement Study (n = 3,996, mean age = 79.5 years). We investigated how demographics (age, sex, educational attainment) and health behaviors (smoking, alcohol consumption, physical activity) modified these associations. All PEGS were positively associated with their corresponding cardiometabolic traits (p < 0.05), and most associations persisted across all racial/ethnic groups. Associations for BMI, HDL-C, and TG were stronger in younger participants, and BMI and HDL-C associations were stronger in females. The CRP association was stronger among those with a high school degree. Finally, the HDL-C association was stronger among current smokers. These findings support PEGS as robust surrogate measures and suggest the associations may differ among subgroups.
ESTRATEGIA INDUSTRIAL DE CHILE PARA LA DÉCADA DE LOS AÑOS 70
Creators: name: Bitar, Sergio
name: Bitar, Sergio
Publisher: name: Humanities Commons
Year: 2022

description: Entre 1968 y 1970 se preparó en CORFO una de las más completas propuestas de estrategia industrial para Chile 1970-80. Ese programa no se logró implementar y los textos quedaron sin difundir. El presente trabajo de recuperación histórica nos transporta a los inicios de los años 70, tiempos convulsos que marcaron un giro en la economía del país y en el quehacer de la CORFO, primero con el gobierno de Salvador Allende y, luego, con la dictadura. Hoy, cuando en el país se abraza la idea de dar un nuevo impulso al desarrollo industrial de Chile, es que debemos poner en perspectiva lo hecho entonces, y sobre esa base imaginar con ambición una nueva etapa. Como lo expresó en 2022 el Vicepresidente Ejecutivo CORFO, José Miguel Benavente, “queremos avanzar hacia un nuevo modelo de desarrollo que sea más inclusivo y sustentable, territorialmente equitativo y basado ya no en la simple extracción y exportación de recursos naturales, sino en actividades más intensiva en ciencia, tecnología e innovación”