cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Akodon (Akodon) serrensis Thomas 1902
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon
Akodon serrensis

description: Akodon (Akodon) serrensis Thomas 1902
Akodon (Akodon) serrensis Thomas 1902, Ann. Mag. Nat. Hist., ser. 7, 9: 61.
Type Locality: Brazil, Paraná State, Serra do Mar, Roca Nova, 1000 m.
Vernacular Names: Serra do Mar Akodont.
Synonyms: Akodon (Akodon) leucogula Miranda Ribeiro 1905.
Distribution: SE Brazil; distributional limits uncertain.
Conservation: IUCN – Lower Risk (lc).
Discussion: Subgenus Akodon, A. mollis species group (Hershkovitz, 1990 c). Recognized as a species since its description (Cabrera, 1961; Gyldenstolpe, 1932; Moojen, 1952). Most strongly differentiated, based on cytochrome b sequences, of six Brazilian Akodon species examined by Geise et al. (2001). The single example of A. serrensis studied by D’Elía et al. (2003) is genetically (cytochrome b) most similar to Thaptomys nigrita, a finding that recommends expansion of sampling and review of the taxon’s assignment within Akodon proper.
New records of sympatry with A. cursor reported by Hershkovitz (1998), who amplified the discrimination of these two morphologically similar species (also see Liascovich and Reig, 1989). Karyotypic and morphometric separation from A. paranaensis illuminated by Christoff et al. (2000) and from A. reigi by González et al. (1998); strong genetic (cytochrome b) divergence from members of A. cursor species group confirmed by Geise et al. (2001). Hershkovitz (1990 c) listed leucogula as a species, but Christoff et al. (2000) demonstrated its synonymy under A. serrensis and uncovered no basis for subspecific recognition. Morphometric variation in a local sample (Paraná, Brazil) investigated by Kosloski (1997), whose finding of two distinct phenetic groupings may relate to one of the species recently described from the region (e.g., A. paranaensis or A. reigi).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1098, DOI: 10.5281/zenodo.7316535
Photostress Recovery Time as a Potential Predictive Biomarker for Age-Related Macular Degeneration
Creators: name: Brandl, Caroline
name: Zimmermann, Martina E.
name: Herold, Janina M.
name: Helbig, Horst
name: Stark, Klaus J.
name: Heid, Iris M.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: age-related macular degeneration (AMD); photostress test; photostress recovery time (PRT); biomarker; population-based study; genetic risk score (GRS)
subject: 610 Medizin

description: Abstract

Purpose: The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort.

Methods: We analyzed photostress recovery time (PRT) and AMD in >1800 AugUR study participants aged 70+ years. On color fundus images from baseline and 3-year follow-up, presence of AMD was graded manually (Three Continent AMD Consortium Severity Scale). Visual acuity (VA) was assessed via Early Treatment Diabetic Retinopathy Study (ETDRS) charts. After a 30-second bleaching of the macular region via direct ophthalmoscope, PRT was measured as the seconds to regain VA.

Results: First, we analyzed 1208 AugUR participants cross-sectionally (288 with early AMD, and 78 with late AMD). Prolonged PRT was associated with early and late AMD versus no AMD (median PRT = 119.5, 198.0 versus 80.0 seconds, respectively; logistic regression odds ratio [OR] = 1.109–1.165 per 10 seconds, P values < 0.0001). Sensitivity analyses using alternative models or restricting to participants after cataract surgery revealed similar ORs. Second, the association was confirmed in an independent cross-sectional AugUR sample (n = 486). Third, in longitudinal analysis of 233 AugUR participants without AMD, prolonged PRT was associated with incident AMD ascertained 3 years later (follow-up time = 3.2 ± 0.2 years, OR = 1.112–1.162 per 10 seconds, P < 0.05). Overall, we demonstrate a significant association of prolonged PRT with AMD cross-sectionally and longitudinally in elderly individuals.

Conclusions: Prolonged PRT might capture retinal function impairment after cell damage before early AMD is visible via color fundus imaging.

Translational Relevance: Our results suggest PRT as quantitative predictive biomarker for incident AMD, making it potentially worthwhile also for clinical care.
Additional file 1 of Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Creators: name: Mao, Tianjiao
name: Wei, Wei
name: Chen, Bo
name: Chen, Yixin
name: Liang, Shuqi
name: Chen, Guiping
name: Liu, Zhuoyuan
name: Wu, Xiaodan
name: Wu, Lihong
name: Li, Xiaomeng
name: Watanabe, Nobumoto
name: Mayo, Kevin H.
name: Pathak, Janak L.
name: Li, Jiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1.
CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea
Creators: name: Hegner, Philipp
name: Lebek, Simon
name: Schaner, Benedikt
name: Ofner, Florian
name: Gugg, Mathias
name: Maier, Lars Siegfried
name: Arzt, Michael
name: Wagner, Stefan
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: obstructive sleep apnea; oxidative stress; CaMKII; contractile dysfunction; arrhythmias
subject: 610 Medizin

description: Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing (SDB). The CaMKII-dependent dysregulation of cellular Ca homeostasis has recently been described in SDB patients, but these studies only partly explain the mechanism and are limited by the patients’ heterogeneity. Here, we analyzed contractile function and Ca homeostasis in a mouse model of obstructive sleep apnea (OSA) that is not limited by confounding comorbidities. OSA was induced by artificial tongue enlargement with polytetrafluorethylene (PTFE) injection into the tongue of wildtype mice and mice with a genetic ablation of the oxidative activation sites of CaMKII (MMVV knock-in). After eight weeks, cardiac function was assessed with echocardiography. Reactive oxygen species (ROS) and Ca transients were measured using confocal and epifluorescence microscopy, respectively. Wildtype PTFE mice exhibited an impaired ejection fraction, while MMVV PTFE mice were fully protected. As expected, isolated cardiomyocytes from PTFE mice showed increased ROS production. We further observed decreased levels of steady-state Ca transients, decreased levels of caffeine-induced Ca transients, and increased pro-arrhythmic activity (defined as deviations from the diastolic Ca baseline) only in wildtype but not in MMVV PTFE mice. In summary, in the absence of any comorbidities, OSA was associated with contractile dysfunction and pro-arrhythmic activity and the inhibition of the oxidative activation of CaMKII conveyed cardioprotection, which may have therapeutic implications.
Temperature Dependence of Relativistic Valence Band Splitting Induced by an Altermagnetic Phase Transition
Creators: name: Hajlaoui, M.
name: D'Souza, S. W.
name: Šmejkal, L.
name: Kriegner, D.
name: Krizman, G.
name: Zakusylo, T.
name: Olszowska, N.
name: Caha, O.
name: Michalička, J.
name: Marmodoro, A.
name: Výborný, K.
name: Ernst, A.
name: Cinchetti, M.
name: Minar, J.
name: Jungwirth, T.
name: Springholz, G.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Altermagnetic (AM) materials exhibit non-relativistic, momentum-dependent spin-split states, ushering in new opportunities for spin electronic devices. While the characteristics of spin-splitting have been documented within the framework of the non-relativistic spin group symmetry, there has been limited exploration of the inclusion of relativistic symmetry and its impact on the emergence of a novel spin-splitting in the band structure. This study delves into the intricate relativistic electronic structure of an AM material, alpha-MnTe. Employing temperature-dependent angle-resolved photoelectron spectroscopy across the AM phase transition, we elucidate the emergence of a relativistic valence band splitting concurrent with the establishment of magnetic order. This discovery is validated through disordered local moment calculations, modeling the influence of magnetic order on the electronic structure and confirming the magnetic origin of the observed splitting. The temperature-dependent splitting is ascribed to the advent of relativistic spin-splitting resulting from the strengthening of AM order in alpha-MnTe as the temperature decreases. This sheds light on a previously unexplored facet of this intriguing material.
Additional file 2 of Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Creators: name: Mao, Tianjiao
name: Wei, Wei
name: Chen, Bo
name: Chen, Yixin
name: Liang, Shuqi
name: Chen, Guiping
name: Liu, Zhuoyuan
name: Wu, Xiaodan
name: Wu, Lihong
name: Li, Xiaomeng
name: Watanabe, Nobumoto
name: Mayo, Kevin H.
name: Pathak, Janak L.
name: Li, Jiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2.
Immunomodulation of Natural Killer Cell Function by Ribavirin Involves TYK-2 Activation and Subsequent Increased IFN-γ Secretion in the Context of In Vitro Hepatitis E Virus Infection
Creators: name: Kupke, Paul
name: Adenugba, Akinbami
name: Schemmerer, Mathias
name: Bitterer, Florian
name: Schlitt, Hans J.
name: Geissler, Edward K.
name: Wenzel, Jürgen J.
name: Werner, Jens M.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: ribavirin; hepatitis E virus; transplantation; immunosuppression; NK cells
subject: 610 Medizin

description: Hepatitis E virus (HEV) is a major cause of acute hepatitis globally. Chronic and fulminant courses are observed especially in immunocompromised transplant recipients since administration of ribavirin (RBV) does not always lead to a sustained virologic response. By in vitro stimulation of NK cells through hepatoma cell lines inoculated with a full-length HEV and treatment with RBV, we analyzed the viral replication and cell response to further elucidate the mechanism of action of RBV on immune cells, especially NK cells, in the context of HEV infection. Co-culture of HEV-infected hepatoma cells with PBMCs and treatment with RBV both resulted in a decrease in viral replication, which in combination showed an additive effect. An analysis of NK cell functions after stimulation revealed evidence of reduced cytotoxicity by decreased TRAIL and CD107a degranulation. Simultaneously, IFN-ɣ production was significantly increased through the IL-12R pathway. Although there was no direct effect on the IL-12R subunits, downstream events starting with TYK-2 and subsequently pSTAT4 were upregulated. In conclusion, we showed that RBV has an immunomodulatory effect on the IL-12R pathway of NK cells via TYK-2. This subsequently leads to an enhanced IFN-ɣ response and thus, to an additive antiviral effect in the context of an in vitro HEV infection.
Akodon (Hypsimys) siberiae Myers and Patton 1989
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon
Akodon siberiae

description: Akodon (Hypsimys) siberiae Myers and Patton 1989
Akodon (Hypsimys) siberiae Myers and Patton 1989, Occas. Pap. Mus. Zool., Univ. Michigan, 720: 4.
Type Locality: Bolivia, Cochabamba Dept., 28 km (by road) W Comarapa, 2800 m; 17°51'S, 64°40'W.
Vernacular Names: Cochabamba Akodont.
Distribution: Known only from the vicinity of the type locality, about 1800-3000 m, Cochabamba and W Santa Cruz Depts., C Bolivia (Anderson, 1997).
Conservation: IUCN – Vulnerable.
Discussion: Subgenus Hypsimys. Morphology and chromosomes suggest that A. siberiae is closely related to A. budini, the type species of Hypsimys (see Myers and Patton, 1989).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1099, DOI: 10.5281/zenodo.7316535
THE EFFICACY OF SLOW DEEP BREATHING IN REDUCING BLOOD PRESSURE AMONG HYPERTENSIVE PATIENTS
Creators: name: Dewi Nurhanifah
name: Kiki Marliana
Publisher: name: Zenodo
Year: 2024
Subjects: Blood Pressure Reduction, Hypertension Management, Non-Pharmacological Intervention, Pre-Experimental Study, And Slow Deep Breathing Exercises.

description: Abstract

The prevalence of hypertension has been steadily increasing over the years. If left unmanaged, hypertension can lead to more severe complications, such as stroke and heart disease. Effectively managing hypertension, including lowering blood pressure through techniques like slow deep breathing, is crucial to preventing these complications. This study aimed to assess the effectiveness of slow deep breathing exercises in reducing blood pressure among hypertensive patients. The research utilized a pre-experimental design with a one-group pretest-posttest design and included a sample of 53 hypertensive patients selected through purposive sampling. Data analysis was carried out using the Wilcoxon signed-rank test. The results revealed that before the slow deep breathing exercises, the majority of blood pressure readings fell into the category of moderate hypertension, with 33 patients (62.3%). Following the intervention, the majority of readings shifted to the category of mild hypertension, with 31 patients (58.5%). The study found a significant impact of slow deep breathing exercises on reducing blood pressure in hypertensive patients, with a p-value of 0.000. In conclusion, incorporating slow deep breathing exercises into the daily routine three times a day can effectively help lower blood pressure in hypertensive patients.
Additional file 1 of Relations between daily stressful events, exertion, heart rate variability, and thoracolumbar fascia deformability: a case report
Creators: name: Brandl, Andreas
name: Engel, Raimund
name: Egner, Christoph
name: Schleip, Robert
name: Schubert, Christian
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file1 (PDF 502 KB)
title: Activité du port de Saint-Malo – 1741 – Porto Rico
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1741 avec le port "Porto Rico"
description: Marchandises arrivées à Saint-Malo : huile
description: Coverage: Grand commerce
description: Bibliographic citation: HAUTIN, Marie-Antoinette. Le Commerce maritime de Saint-Malo en 1741. DES : Histoire : Rennes : 1964 (Bibliothèque François-Lebrun, MH 1036)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Postoperative free flap monitoring in reconstructive surgery—man or machine?
Creators: name: Knoedler, Samuel
name: Hoch, Cosima C.
name: Huelsboemer, Lioba
name: Knoedler, Leonard
name: Stögner, Viola A.
name: Pomahac, Bohdan
name: Kauke-Navarro, Martin
name: Colen, David
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: flap monitoring, free tissue transfer, microvascular reconstruction, microsurgery, free flap, reconstructive surgery
subject: 610 Medizin

description: Free tissue transfer is widely used for the reconstruction of complex tissue defects. The survival of free flaps depends on the patency and integrity of the microvascular anastomosis. Accordingly, the early detection of vascular comprise and prompt intervention are indispensable to increase flap survival rates. Such monitoring strategies are commonly integrated into the perioperative algorithm, with clinical examination still being considered the gold standard for routine free flap monitoring. Despite its widespread acceptance as state of the art, the clinical examination also has its pitfalls, such as the limited applicability in buried flaps and the risk of poor interrater agreement due to inconsistent flap (failure) appearances. To compensate for these shortcomings, a plethora of alternative monitoring tools have been proposed in recent years, each of them with inherent strengths and limitations. Given the ongoing demographic change, the number of older patients requiring free flap reconstruction, e.g., after cancer resection, is rising. Yet, age-related morphologic changes may complicate the free flap evaluation in elderly patients and delay the prompt detection of clinical signs of flap compromise. In this review, we provide an overview of currently available and employed methods for free flap monitoring, with a special focus on elderly patients and how senescence may impact standard free flap monitoring strategies.
Soninniinae Buckman 1892
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Ammonoidea
Sonniniidae

description: Subfamily SONINNIINAE Buckman, 1892
DESCRIPTION
Serpenticone, platycone to oxycone macroconchs, sometimes reaching large sizes, microconchs being much smaller. Whorl sections vary from subrectangular, subtriangular, oval to ogival, and the venter has a more or less developed hollow keel persisting to the BC. Ornamentation varies widely from smooth forms, to others with strongly ribbed or ribbed and tuberculate. The innermost whorls can be smooth, whereas later inner whorls have ribs. Many forms have well-developed tubercles or spines. The degree to which the spinose/tuberculate stage persists is highly variable and specimens rarely retain strong ribbing beyond the end of the PH, whereas in others the ornamentation is reduced to the inner whorls and from an early stage are striated or smooth. Complete macroconchs [M] have simple peristomes with plain mouth borders. In microconchs [m], the aperture morphology is variable, but usually they have expanded lateral lappets. Like the corresponding macroconchs, microconchs can have nontuberculate, tuberculate, and even spiny internal whorls. The septal suture is relatively complex, with a ramified deep L, and slightly retracted U 2 -U 5 lobes.
REMARKS
As mentioned above, Asthenoceras, Fontannesia, Newmarracarroceras, and Dorsetensia, all included within Sonniniinae in the new version of the Treatise (Howarth 2013), should be separated from this subfamily and transferred to Grammoceratinae (the first three) and Witchelliinae (the last). The more common dimorphism of Sonniniinae appears to belong to the aforementioned type 1, i.e. large, “classical” macroconchs associated with relatively small macroconchs (mesoconchs according to Chandler 2019) with plain mouth borders and without lateral lappets. Coexisting with Sonninia [M] and Sonninites [M], microconchiate forms also occur with welldeveloped lateral lappets (aforementioned dimorphism type 2, possibly representing their dimorphic partners. In this case, the two types of dimorphism would be clearly represented in this subfamily.
DISTRIBUTION
Sonniniinae range throughout the Upper Aalenian (Concavum Zone)-Lower Bajocian (Humphriesianum Zone) interval, with a worldwide distribution, except in the Boreal Realm. In the Subbetic domain, they have this stratigraphic range, and occur in the External, Median, and Internal subdomains, being most abundant in the central sector of the Median Subbetic, the origin of most of the specimens studied here.
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on page 808, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Argyrogramma signata Fabricius 1775
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Argyrogramma
Argyrogramma signata

description: * Argyrogramma signata (Fabricius, 1775)
(Fig. 20)
Material examined. Somali region, Jijiga. 1600 m. VIII.2011. Leg. Kravchenko V.; Somali region, Handew. 1800 m. VIII.2011. Leg. Kravchenko V.
Literature. Behounek & Ronkay 1989; Behounek et al. 2010; Dufay 1970; Hacker, et al. 2001; Hacker et al. 1999; Ronkay 1987.
General distribution pattern. In tropical and subtropical Africa: Burkina Faso, Comoros, Eritrea, Ghana, Réunion, Madagascar, Mauritania, Mauritius, Seychelles, Sierra Leone, South Africa and São Tomé & Principe. In the Palearctic region it has been found in the Canaries, Yemen, Oman and nearly all over tropical Asia.
Distribution in Ethiopia. Throughout country except elevations above 3.000 m. Common.
Host plants. Polyphagous. Recorded on Eucalyptus sp. (Myrtaceae), Nicotiana sp. (Solanaceae).
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 241, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Sonninia Douville 1879
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Sonninia

description: Genus Sonninia Douvillé, 1879
Sonninia Douvillé, 1879: 92.
Waagenia Bayle, 1878: pl. 84, non Kriechbaumer, 1874 (insect).
TYPE SPECIES. — Waagenia propinquans Bayle, 1878 (Bayle 1878: pl. 84, fig. 1 [OD]).
DESCRIPTION
The following description is modified from the Treatise (Howarth 2013). Evolute planulate shells, becoming more involute and compressed on larger whorls. The whorl section is rounded initially, becoming more or less compressed on outer whorls, with a strong keel on rounded or arched venter. The ribs and tubercles are highly variable. The ribs are often strong, mainly on inner whorls, but may be irregular. Large, well-spaced midlateral tubercles or spines occur at least on early and middle whorls. This genus is dimorphic, but some small forms (mesoconchs), which have plain mouth borders, are undefined. Others have lateral lappets and, like the corresponding macroconchs, can have non-tuberculate, tuberculate, and even spiny internal whorls.
REMARKS
Howarth (2013: 115) states that the author of Sonninia is Douvillé, not Bayle, as assumed previously, becauseDouvillé (1879: 92) was the author of the note in which S onninia was proposed as a replacement for Bayle’s preoccupied genus Waagenia.
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on page 809, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Additional file 1 of Assessment of hypoxia and its dynamic evolution in glioblastoma via qBOLD MRI: a comparative study with metformin treatment
Creators: name: Wang, Dongdong
name: Chen, Jie
name: Ying, Yinwei
name: Zhao, Xinxin
name: Mei, Nan
name: Li, Xuanxuan
name: Zhu, Yuqi
name: Cui, Jin
name: Wu, Pu-Yeh
name: Lu, Yiping
name: Yin, Bo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: ELECTRONIC SUPPLEMENTARY MATERIAL
title: Activité du port de Saint-Malo – 1727 – Charente
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: alcool

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1727 avec le port "Charente"
description: Marchandises arrivées à Saint-Malo : eau de vie
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; alcool
description: Coverage: Grand cabotage
description: Bibliographic citation: ROUYER, Maryvonne. Documents sur le commerce malouin en 1713 et 1727. DES : Histoire : Rennes : 1963 (Bibliothèque François-Lebrun, MH 1019)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
title: Design of Timing Circuit for Fuel Injection Conversion and Development of Laboratory to Analyze Engine Performance Using a Dynamometer
Creators: name: Limaye, Aditi Jayram
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2015

description:
A fundamental facility was built to analyze some of the basic parameters involved in engine performance, namely torque and power output of the engine. One of the objectives was to convert a carbureted engine into a fuel injection or (Fl) engine. This was achieved by designing and creating a timing circuit that is required to trigger the electronic fuel injector or (EFI). The facility was designed around a dynamometer and a fuel delivery system; that provided a specialized tool to analyze engines and injectors.

The results from the carbureted experiments and the FI experiments were compared to the rated specifications of the engine. The results indicated that the overall performance of the engine was not affected due the conversion from the carbureted to the Fl engine. The results showed that the FI engine yielded 33% improvement in the torque and 25% improvement in power output in comparison to that of the carbureted experiments. These results were very much similar to that of the rated specifications of the engine, with a 9% deviation for the torque and 3% deviation for the power output produced. The development of the facility encountered many challenges, but the majority of the issues were resolved to achieve accurate results.
INNOVATIVE APPROACHES AND MINERAL WATER PRODUCTION — THE SIGNIFICANCE OF THE CHST44 WELL AS A SOURCE OF HIGH-QUALITY MINERAL WATER
Creators: name: Hakimov, Abdulhakim
name: Isakov, Abidjan
Publisher: name: Zenodo
Year: 2025

description: This article is dedicated to the quality, geological features, and production potential of mineral water extracted from the CHST44 well located in the Khanabad district of Andijan region. The geological conditions of the well, the chemical composition of the water, mineralization level, hardness index, and pH balance have been analyzed, highlighting its advantages as a source of drinking and mineral water. The efficiency of the well, pump technologies, and exploitation methods have been recommended, emphasizing the importance of sustainable water resource management. Additionally, detailed information is provided on the positive effects of the minerals in the water on human health, including strengthening bone and dental health, improving gastrointestinal function, and detoxifying the body. This research encompasses important scientific approaches aimed at the effective utilization and economic and ecological development of mineral water resources.
Tumor Immune Microenvironment Heterogeneity at the Invasion Front and Tumor Center in Oral Squamous Cell Carcinoma as a Perspective of Managing This Cancer Entity
Creators: name: Mamilos, Andreas
name: Lein, Alexander
name: Winter, Lina
name: Ettl, Tobias
name: Künzel, Julian
name: Reichert, Torsten E.
name: Spanier, Gerrit
name: Brochhausen, Christoph
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: head and neck cancer; OSCC; immunemicroenvironment; pathology; immunohistochemistry; spatial distribution; topology
subject: 610 Medizin

description: Background:
Evaluating the tumor microenvironment and its influence on clinical management and therapy response is becoming increasingly important. However, only a few studies
deal with the spatial distribution of immune cells within the tumor. This study aimed to describe the topology of immune cells in the microenvironment of oral squamous cell carcinoma
(OSCC) sectioned by tumor invasion front and tumor center and to test their prognostic relevance regarding patient survival.

Methods:
A total of 55 OSCC patient specimens were collected retrospectively. The cancer tissue was immunohistochemically stained using an automated tissue stainer Ventana Benchmark Ultra (Roche) and analyzed using discrete expression marker profiles on immune cells. We investigated CD4+ lymphocytes, CD8+ lymphocytes, CD68+ macrophages, CD163+ macrophages, and M1 macrophages regarding their spatial distribution.

Results:
The statistical analysis revealed that the quantity and distribution of CD4+ (p = 0.007), CD8+ (p < 0.001),
CD68+ (p < 0.001), CD163+ cells (p = 0.004), and M1 (p < 0.001) macrophages were significantly higher at the invasion front compared to the tumor center in all observed cases. However, high and low immune cell counts in the tumor center and invasion front were not associated with overall survival.

Conclusion:
Our results show two distinct immune microenvironments of the tumor center compared to the invasion front. Future studies are needed to explore how these results can be leveraged to improve patient therapy and outcome.
Additional file 1 of Theta power reduction and theta–gamma coupling desynchronization are associated with working memory interference and anxiety symptoms in panic disorder: a retrospective study
Creators: name: Ahn, Ji Seon
name: Hong, Hye-Jin
name: Lee, Jee Hang
name: Park, Jin Young
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Supplementary Material 1.
Akodon (Akodon) simulator Thomas 1916
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon
Akodon simulator

description: Akodon (Akodon) simulator Thomas 1916
Akodon (Akodon) simulator Thomas 1916, Ann. Mag. Nat. Hist., ser. 8, 18: 335.
Type Locality: Argentina, Tucumán Prov., San Pablo, Villa Nouges, 1200 m.
Vernacular Names: White-throated Akodont.
Synonyms: Akodon (Akodon) glaucinus Thomas 1919; Akodon (Akodon) tartareus Thomas 1919.
Distribution: E lower Andean slopes, 650-2400 m, from SC Bolivia (Tarija; Anderson, 1997) to NW Argentina (Jujuy to Catamarca; Mares et al., 1997; Ortiz et al., 2000 a).
Conservation: IUCN – Lower Risk (lc).
Discussion: Subgenus Akodon, A. varius species group (Myers, 1989). Named as a species but later placed as a subspecies of A. varius (Cabrera, 1961; Thomas, 1926). Returned to species rank by Myers (1989), who emphasized the need for continued study of their level of differentiation; he recognized glaucinus and tartareus as distinctive subspecies. Karyology and morphometrics reviewed, as A. varius, by Bárquez et al. (1980); age variation in a large Argentinian sample analysed by Eschevarria (1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1099, DOI: 10.5281/zenodo.7316535
Statin Use Ameliorates Survival in Oral Squamous Cell Carcinoma—Data from a Population-Based Cohort Study Applying Propensity Score Matching
Creators: name: Spoerl, Steffen
name: Gerken, Michael
name: Fischer, René
name: Spoerl, Silvia
name: Kirschneck, Christian
name: Wolf, Stefanie
name: Taxis, Juergen
name: Ludwig, Nils
name: Biermann, Niklas
name: Reichert, Torsten E.
name: Spanier, Gerrit
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: oral squamous cell carcinoma; OSCC; HNSCC; statin; hydroxymethylglutaryl CoA reductase inhibitor; cardiovascular disease; CVD; survival; propensity score matching; PSM
subject: 610 Medizin

description: The anti-cancer properties of statins have attracted much attention recently, but little is known about the prognostic role of statins in oral squamous cell carcinoma (OSCC). In a retrospective approach, we analyzed a population-based cohort of 602 OSCC patients with primary curative tumor resection to negative margins and concomitant neck dissection between 2005–2017. Long-term medication with statins was correlated with overall survival (OAS) as well as recurrence-free survival (RFS) using uni- and multivariable Cox regression. Additionally, propensity score matching was applied to adjust for confounders. Statin use was present in 96 patients (15.9%) at a median age of 65.7 years. Statin treatment correlated with ameliorated survival in multivariable Cox regression in the complete cohort (OAS: HR 0.664; 95% CI 0.467–0.945, p = 0.023; RFS: HR 0.662; 95% CI 0.476–0.920, p = 0.014) as well as matched-pair cohort of OSCC patients (OAS: HR 0.691; 95% CI 0.479–0.997, p = 0.048; RFS: HR 0.694; 95% CI 0.493–0.976, p = 0.036) when compared to patients not taking statins at time of diagnosis. These findings were even more pronounced by sub-group analysis in the matched-pair cohort (age < 70 years). These data indicate that statin use might ameliorate the oncological outcome in primarily resected OSCC patients, but prospective clinical trials are highly recommended.
Gender Differences in Symptom Burden, Functional Performance and Global Quality of Life of Lung Cancer Patients Receiving Inpatient versus Outpatient Treatment
Creators: name: Koch, Myriam
name: Rothammer, Tobias
name: Rasch, Frederike
name: Müller, Karolina
name: Braess, Jan
name: Koller, Michael
name: Schulz, Christian
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: gender differences, lung cancer, quality of life, EORTC QLQ-C30/EORTC QLQ-LC29, outpatient versus inpatient treatment
subject: 610 Medizin

description: Background: 
Lung cancer may cause severe impairment of quality of life. An increasing number of lung cancer patients are receiving outpatient chemotherapy. However, little is known about gender aspects in the areas of impaired QoL in outpatient versus inpatient lung cancer patients. The aim of the study was to investigate this.
Methods: 
We report from a prospective, multicenter study to analyze the EORTC QLQ-LC29, a new designed module to assess the QoL of lung cancer patients. The participants filled out the EORTC QLQ-C30 and the recently updated lung cancer module QLQ-LC29.
Results: 
A total of 198 lung cancer patients (73 female and 125 male, mean 64.5 age years) during first-line therapy were enrolled in this study by completing the both questionnaires. Women showed higher symptom scores, when being inpatient. Significant results were found regarding nausea/vomiting (mean women = 17.6 and mean men = 9.3, p = 0.037) and hair loss (mean women = 40.0 and mean men = 21.7, p = 0.010), although women received fewer chemotherapy treatments than their male counterparts (women n = 47, 64.4% and men n = 86, 68.8%). When it comes to global QoL, men report a significant worse QoL than women (mean women = 57.5 and mean men = 46.1, p = 0.016), when being inpatient. As outpatients, men report significant results regarding sore mouth and tongue (mean women = 1.2 and mean men = 13.5, p = 0.012).
Conclusion: 
This study adds to the literature in showing the typical gender difference effect on QoL, suggesting men suffer less than women, is not a universal phenomenon irrespective of being inpatient or outpatient. It also confirms the hypothesis that the symptom burden is higher with inpatients than outpatients.
Additional file 1 of Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models
Creators: name: Power, Saige K.
name: Venkatesan, Sridevi
name: Qu, Sarah
name: McLaurin, JoAnne
name: Lambe, Evelyn K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Additional file 1: Table S1 Neuronal intrinsic properties of layer 6 pyramidal neurons by genotype in mice. Table S2 Neuronal intrinsic properties of layer 6 pyramidal neurons by genotype in rats. Figure S1 There are no significant differences in intrinsic excitability between nTg and TgCRND8 layer 6 pyramidal neurons in mouse.  Figure S2 Decrease in intrinsic excitability between F344 and TgF344 layer 6 pyramidal neurons in mid disease.  Figure S3 Cholinergic treatments are consistently effective in prefrontal layer 6 pyramidal neurons of TgCRND8 AD and nTg controls. Figure S4 Cholinergic treatments are consistently effective at early to mid-AD and late-AD in layer 6 pyramidal neurons of prefrontal cortex
Akodon (Akodon) spegazzinii Thomas 1897
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon
Akodon spegazzinii

description: Akodon (Akodon) spegazzinii Thomas 1897
Akodon (Akodon) spegazzinii Thomas 1897, Ann. Mag. Nat. Hist., ser. 6, 20: 216.
Type Locality: Argentina, Salta Prov., lower Río Cachí.
Vernacular Names: Spegazzini's Akodont.
Synonyms: Akodon (Akodon) alterus Thomas 1919; Akodon (Akodon) tucumanensis J. A. Allen 1901.
Distribution: E Andean slopes, 400 to 1000 m, NW Argentina.
Conservation: IUCN – Lower Risk (lc).
Discussion: Subgenus Akodon, A. boliviensis species group (Myers et al., 1990). Formerly considered a subspecies of A. boliviensis (Cabrera, 1961); Myers et al. (1990) segregated spegazzinii as a species, retaining tucumanensis as a subspecies. Karyology and morphometrics reviewed, as A. boliviensis tucumanensis, by Barquez et al. (1980). Cabrera (1961) placed alterus in full synonymy with A. boliviensis tucumanensis; karyotypes of alterus and tucumanensis reported as identical (2n = 40, FN = 40) by Blaustein et al. (1992), who also discussed their weak allozymic and morphological divergence. Mares et al. (1997) listed alterus and tucumanensis as species principally based on their different ecological associations. Another complex of small akodonts in need of revision; also see remarks under A. aliquantulus.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1099, DOI: 10.5281/zenodo.7316535
title: Compte rendu de la séance du 23 juin 2018
Creators: name: Brahamcha-Marin, Jordi
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Relation: https://groupehugo.hypotheses.org
Sonninia (Sonninia) patella
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Sonninia
Sonninia patella

description: Sonninia (Sonninia) patella (Waagen, 1867) [M] (Fig. 7E)
Ammonites patellum Waagen, 1867: 597, pl. 25, figs 2, 3 (LT designed by Oechsle 1958).
Sonninia patella – Dorn 1935: 51, text-fig. pl. 5, figs 1, 2; pl. 14, figs 1, 6. — Pavia 1983: pl. 4, fig. 4. — Schlegelmilch 1985: 61, pl. 18, fig. 2 (LT refigured). — Rioult et al. 1997: 48, pl. 14, figs 3a, b. — De Baets et al. 2008: 571, fig. 6b. — Chandler & Whicher 2015: pl. 13, fig. 4 (reproduction of the original figure of Waagen 1867). — Dietze et al. 2020: 66, pl. 6, fig. 8, pl. 12, figs 4-5, pl. 14, fig. 18. — Sadki & Dietze 2021: 7, text-fig.10 (LT refigured) (cum syn.).
Sonninia cf. patella [M] – Dietze et al. 2009: 25, pl. 7, fig. 1, pl. 9, fig. 5.
MATERIAL EXAMINED. — JAC11. R.62, JAC11. R.63, JAC13. R.2, JAC20.(7-2).1, JAC20.(7-6).5 and JAC20. R.1.
MEASUREMENTS. — See Table 2.
DESCRIPTION
Medium-sized planulate shell, relatively involute with outer whorls being more involute than the inner ones. The whorl section is ovate, from subrectangular to compressed subtriangular. The umbilical wall, oblique in the inner whorls, becomes vertical in the last whorls. The convex flanks converge to a somewhat narrow venter, which bears a relatively prominent floored keel. The inner whorls, visible in a specimen, are ornamented with rather strong irregular, often bundled, radial sigmoid ribs, some of which split at a node located near the umbilical edge. Ribs erase gradually on the external whorls, and the BC end can be almost smooth.
REMARKS
S. (S.) patella is a frequently cited species, but, except for the HT, few specimens have been figured, and these show noteworthy intraspecific variations. The most similar species may be S. (S.) propinquans (Bayle, 1878), but the latter is slightly more evolute, has an ovate-ogival whorl section, no vertical umbilical wall, and more persistent ribbed and tuberculate stages.
DISTRIBUTION
The LT comes from an unknown level of the Sowerbyi oolith of Gingen/Fils of the eastern Swabian Alb (Dietze et al. 2005; Sadki & Dietze 2021). The species usually occurs in the lower half of the Propinquans Zone of diverse Western European localities, but it has also been cited in the Laeviuscula Zone. Subbetic specimens are from the Propinquans Zone (Patella Subzone), from Sierra de Alta Coloma area (JAC11, JAC13, JAC20 sections, Jaén Province).
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on page 812, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma
Creators: name: Weber, Florian
name: Treeck, Oliver
name: Mester, Patricia
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: liver fibrosis; immune cells; hepatic stellate cells; β-catenin; bone morphogenetic proteins
subject: 610 Medizin

description: BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) is a transmembrane pseudoreceptor structurally related to transforming growth factor (TGF)-β type 1 receptors (TGF-β1Rs). BAMBI lacks a kinase domain and functions as a TGF-β1R antagonist. Essential processes such as cell differentiation and proliferation are regulated by TGF-β1R signaling. TGF-β is the best-studied ligand of TGF-βRs and has an eminent role in inflammation and fibrogenesis. Liver fibrosis is the end stage of almost all chronic liver diseases, such as non-alcoholic fatty liver disease, and at the moment, there is no effective anti-fibrotic therapy available. Hepatic BAMBI is downregulated in rodent models of liver injury and in the fibrotic liver of patients, suggesting that low BAMBI has a role in liver fibrosis. Experimental evidence convincingly demonstrated that BAMBI overexpression is able to protect against liver fibrosis. Chronic liver diseases have a high risk of hepatocellular carcinoma (HCC), and BAMBI was shown to exert tumor-promoting as well as tumor-protective functions. This review article aims to summarize relevant studies on hepatic BAMBI expression and its role in chronic liver diseases and HCC.
Open Pyeloplasty in Infants under 1 Year—Proven or Meaningless?
Creators: name: Vauth, Franziska
name: Zöhrer, Pirmin
name: Girtner, Florian
name: Rösch, Wolfgang H.
name: Hofmann, Aybike
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: ureteropelvic junction obstruction; abdominal surgery; small infants; long-term outcome; parental satisfaction
subject: 610 Medizin

description: The use of minimally invasive surgery (MIS) to treat ureteropelvic junction obstruction (UPJO) in children has significantly increased. Nowadays, open pyeloplasty (OP) seems to lose importance. The aim of this study is to evaluate the safety and efficacy of OP in infants < 1 year. Medical records of patients < 1 year with UPJO who had undergone retroperitoneal OP (January 2008–February 2022) at our institution were retrospectively analyzed. Included patients were operated on according to a modified Anderson–Hynes technique. All clinical, operative, and postoperative (1 month–5 years’ follow-up) data were collected. Additionally, a nonvalidated questionnaire was sent to the patients/parents. A total of 162 infants (124 boys) met the inclusion criteria. The median age at surgery was 3 months (range: 0–11 months). The median operation time was 106 min (range: 63–198 min). None of the patients had severe surgical complication (Clavien–Dindo > 3). The nonvalidated questionnaire showed a high impact of quality of life. Follow-up was in median 30.5 months (0–162 months). OP is still a reliable procedure with good long-term results especially in infants < 1 year of age, which can be performed in a variety of centers.