cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Developing signal amplification strategies for sensitive detection of low abundance biomolecules
Creators: name: Lu, Jie
Publisher: name: Macquarie University
Year: 2022
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: Developing sensitive and rapid assays to quantify trace amounts of target biomolecules is vital to diagnosing specific diseases, understanding mechanisms of disease pathogenesis, tailoring effective treatments, and monitoring therapeutic outcomes. Current luminescent bioassays have significant limitations in dealing with background noise (auto-fluorescence), and concentration-induced self-quenching and non-specific binding of the luminescent probe, and are ineffective for rapid detection of low abundance biomolecules.
 This thesis explores a suit of novel luminescence-based techniques for ultrasensitive target-specific detection of biomolecules either immobilized on cell surface or suspended in a solution. Techniques of time-resolved detection after pulsed excitation and upconversion detection by infrared excitation have been employed to effectively suppress the auto-fluorescence; lanthanide materials are used to avoid concentration quenching so that nanoparticles highly doped with hundreds to thousands of emitters have been introduced to essentially amplify the signal strength; a target recycling technique has been further developed to enhance the detection sensitivity of DNA bead assays; a simple but robust bio-/nano-conjugation strategy for SUPER dots has been developed to improve the binding efficiency and specificity; luminescence biosensing of multiple analytes has been extended beyond the current spectral multiplexing to harness a new dimension-temporal multiplexing based on multiple selectable luminescence lifetimes of new-generation luminescent bioprobes.
 The research program reported herein has involved four parallel research projects with four key technologies successfully demonstrated: 1). Resolving and quantifying trace levels of surface antigens immobilized on rare-event cells in background-free condition by using lanthanides-dye-rich luminescence nanoparticles(chapter 2); 2). Exploring the bio-conjugation method of lanthanide upconversion SUPER dots probes (chapter 3); 3). Achieving improved sensitivity of DNA detection in flow cytometry by using the Exonuclease III assisted target recycling technique (chapter 4); 4). Expanding the multiplexing capacity through successful application of lifetime-encoded luminescent nanocrystals and microspheres to enable rapid detection of multiple pathogen DNAs (chapter 5).
 This thesis adopts the “thesis-by-publication” approach, and is presented by a traditional style introduction chapter but appended by a 1st-authored review article, one traditional conclusion chapter, and four result chapters of five journal publications (two published in Analytical Chemistry as 1st author, one manuscript waiting for IP protection clearance as 1st author, and one in Nature Communications as 2nd author and one in Nature Photonics as a co-author).
An International Support Programme for Sustainable Investment Facilitation
Creators: name: Sauvant, Karl P.
name: Hamdani, Khalil
Publisher: name: Columbia University
Year: 2015
Subjects: International relations
Sustainable development--Economic aspects
Investments, Foreign
Sustainable development

description: The global challenges of poverty, sustainable development, and climate change are being tackled with renewed vigour in international negotiations of sustainable development goals for 2016–2030. New commitments also mean increased demands for investment—quantitatively more and qualitatively more sustainable. The latter depends on unleashing the inherent package of benefits embedded in capital and on creating shared value for all stakeholders. Much evidence suggests that sustainability can be commercially viable under appropriate policy frameworks. Hence, the need to put such frameworks in place, globally and nationally, to ensure meeting the increased investment demands of the future. Actions at the national level will require international support. This note advances the case for an international support programme for sustainable investment facilitation. As it explains, potentially all investments are sustainable, but the appropriate policy frameworks need definition, often in novel ways and increasingly in partnership with multiple stakeholders, domestic and foreign. Facilitating investment for future needs, therefore, is not a matter of promotion-as-usual, but a process of discovery and diffusion of new approaches and applications, a process that needs nurturing and support by the international community. Ways in which such backing can be provided to an international support programme for sustainable investment facilitation are discussed in detail, including making use of the World Trade Organization- (WTO) led Aid-for-Trade Initiative and the recently adopted WTO Trade Facilitation Agreement. The issues mentioned for possible inclusion in the support programme, as well as the options outlined on how such a programme could be put in place, are illustrative. The key premise is the importance—and urgency—of creating more favourable conditions for sustainable FDI flows to meet the investment needs of the future. As governments and the private sector increasingly share this view, they will hopefully muster the political will and find the appropriate venue to put an international support programme for sustainable investment facilitation in place.
The relaxation matrix for symmetric tops with inversion symmetry. II. Line mixing effects in the ν1 band of NH₃
Creators: name: Boulet, Christian
name: Ma, Qiancheng
Publisher: name: Columbia University
Year: 2016
Subjects: Ammonia--Spectra
Ammonia
Chemistry, Physical and theoretical
Spectral line broadening
Spectral line formation
Spectrum analysis

description: Line mixing effects have been calculated in the ν1 parallel band of self-broadened NH₃. The theoretical approach is an extension of a semi-classical model to symmetric-top molecules with inversion symmetry developed in the companion paper [Q. Ma and C. Boulet, J. Chem. Phys. 144, 224303 (2016)]. This model takes into account line coupling effects and hence enables the calculation of the entire relaxation matrix. A detailed analysis of the various coupling mechanisms is carried out for Q and R inversion doublets. The model has been applied to the calculation of the shape of the Q branch and of some R manifolds for which an obvious signature of line mixing effects has been experimentally demonstrated. Comparisons with measurements show that the present formalism leads to an accurate prediction of the available experimental line shapes. Discrepancies between the experimental and theoretical sets of first order mixing parameters are discussed as well as some extensions of both theory and experiment.
Bioeconomics of Fraser River sockeye salmon fisheries
Creators: name: Marsden, Allan Dale
Publisher: name: University of British Columbia
Year: 2013

description: Sockeye salmon (Oncorhynchus nerka) in the Fraser River are immensely important to British Columbia's culture and economy. Despite centuries of exploitation and decades of intensive study there remain several key uncertainties about the biological system, including those around dramatic four-year cycles of abundance and pre-season projections of how many fish will return in a given year. Recent years have seen declines in the productivity of some stocks as well as broader conservation concerns, leading to closure of some commercial fisheries, and it appears that greater economic beneﬁts may only be obtained if greater conservation risks are incurred. However, the existing literature contains no analysis focused on bioeconomic analysis of trade-offs between economic and conservation objectives in such complex multi-stock, multi-fleet fisheries. This dissertation develops a bioeconomic simulation model to examine these trade-offs. The model is applied to the Fraser River sockeye salmon fishery and parameterized using historical biological, fishery and economic data. In the first set of analyses, the fishery is simulated retrospectively from 1952 through 1998 and the economic outcomes of several management strategies are examined. In the remaining analyses the fishery is simulated 24 years into the future in a prospective analysis, assuming either that the long-term average productivity regime is still valid, or that recently observed changes in productivity are permanent. Given the outcomes of these simulations the trade-offs between economic beneﬁts and conservation risk are described. The retrospective analysis showed that if relatively simple harvest rules had been implemented historically, the fishery could have been 20-200% more profitable, depending on the particular harvest rule applied and the mechanism underlying stock dynamics. The prospective analysis under the long-term average productivity regime found that there is a policy region that would yield significantly greater economic beneﬁts than the currently applied policy while only minimally increasing conservation risk. Under the modified productivity regime, however, conservation risk is uniformly and unavoidably higher, and the trade-offs become more difficult in the sense that relatively more conservation risk must be incurred to obtain greater economic benefit.
The OH Masers Towards IRAS 19092+0841
Creators: name: Edris, K. A.
name: Fuller, G. A.
name: Etoka, S.
name: Cohen, R. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context. Maser emission is a strong tool for studying high mass star forming regions and their evolutionary stages. OH masers in particular can trace the circumstellar material around protostars and determine their magnetic field strengths at milliarcsecond resolution. Aims. Imaging OH maser mission towards high mass protostellar objects to determine their evolutionary stages and to locate the detected maser emission in the process of high mass star formation. Methods. In 2007, we surveyed OH maser towards 217 high mass protostellar objects to study its presence. In this paper, we present a follow up MERLIN observations of a ground state OH maser emission towards one of these objects, IRAS 19092+0841. Results. Emission from the two OH main spectral lines, 1665 and 1667 MHz, were detected close to the central object. The positions and velocities of the OH maser features have been determined. The masers are distributed over a region of ~ 500 corresponding to 22400 AU (or ~ 0.1 pc) at a distance of 4.48 kpc. The polarization properties of the OH maser features were determined as well. We identify three Zeeman pairs from which we inferred a magnetic field strength of ~ 4:4mG pointing towards the observer. Conclusions. The relatively small velocity spread and the relatively wide spacial distribution of the OH maser features support the suggestion that this object could be in an early evolutionary state before the presence of disk and/or jet/outfows.
description: 6 pages, 2 figures and 3 tables
Supplementary Material from The origins and spread of the opium poppy (Papaver somniferum L.) revealed by genomics and seed morphometrics
Creators: name: Machado, Rui
name: Bonhomme, Vincent
name: Soteras, Raül
name: Jeanty, Angele
name: Bouby, Laurent
name: Evin, Allowen
name: Fernandes Martins, M. Joao
name: Gonçalves, Sandra
name: Antolín, Ferran
name: Salavert, Aurélie
name: Oliveira, Hugo Rafael Cardoso
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 310899
subject: Plant biology not elsewhere classified

description: ESM17A_PCA_Setigerum-Somniferum_noMD_diploid.pdf
title: Nature as a model: Using phospholipids as coating material for lipid nanoparticles to imitate natural lipoproteins
Creators: name: Laabs, Moritz
name: Mulac, Dennis
name: Wünsch, Angelika
name: Langer, Klaus
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2023
Subjects: subject: lipid nanoparticles
subject: drug delivery
subject: nanomedicine
subject: phospholipids
subject: 540
subject: 615.19

description: Lipid nanoparticles (LNPs) have attracted much attention in recent years, with the overall research on lipid-based drug delivery systems receiving a huge boost due to the approval of COVID-19-vaccines. In our working group, we developed a new LNP-system that mimics endogenous lipoproteins using the following components: (a) a hydrophobic core for stable incorporation of a water-insoluble drug and (b) an adsorptive phospholipid-coating as a stabilization and functionalizing agent to bind functional proteins like apolipoprotein E adsorptively. Therefore, the conditions that are crucial for stable embedment of the used model drug substances flurbiprofen and flurbiprofenaxetil were defined by measuring their release behavior from LNPs after incorporation in vitro. Very poor water solubility and independence of this solubility from pH changes could be identified as structural requirements for formulations. Regarding the coating properties, a phospholipid mixture from soybean (soy lecithin) was investigated with respect to its suitability for coating nanoparticle cores. The ability and efficiency of these phospholipids to adsorptively bind apolipoprotein E was determined by SDS-PAGE and CBQCA assay. Overall, the successful preparation of different natural inspired systems could be achieved and are to be tested for their biological behavior in different cell culture models.
Red alder : a qualitative supply chain analysis in coastal British Columbia, Canada
Creators: name: Nadir, Daniel Clayton
Publisher: name: University of British Columbia
Year: 2013

description: Red alder (Alnus rubra, Bong.) has been identified as a potentially important species in the literature related to climate change in coastal British Columbia. This research project was conducted to address the question, “What steps are needed to develop an integrated hardwood supply chain in coastal BC?” Using multiple informant interviews, and combining these with secondary data sources and a social and historical context, the aim of this study was to generate recommendations on what steps would be needed to develop a viable hardwood supply chain on the coast of BC. The major issues that were identified during the literature review were combined with ones that emerged during the interviews, and together, form the results of this study. Specifically, key emergent issues revolved around timber supply, products, markets, production, and the supply chain for red alder. The results of the study shed light on a perceived conifer bias, the need to evaluate the existing red alder forest inventory, variation in hardwood harvest methods, the potential impacts of climate change, and the impact government forest policy has on the hardwood industry in BC. Further results pertained to the manufacturing and marketing of non-commodity (value-added) wood products, and the challenges to actors throughout the hardwood supply chain in 2011. Based on the review of existing literature and the results of this study, a large and coordinated effort will be required to adequately develop the supply chain given the existing economic conditions. Strategic decisions need to be implemented at many different levels to foster a vibrant hardwood supply chain. The current hardwood supply chain in coastal BC is weakening, and inefficiencies are present throughout the supply chain. Transforming this body of knowledge into a cohesive plan is what is needed to foster a vibrant and competitive hardwood manufacturing industry on the coast of BC that includes red alder.
Density-sensitive semisupervised inference
Creators: name: Azizyan, Martin
name: Singh, Aarti
name: Wasserman, Larry
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistics Theory (math.ST)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Semisupervised methods are techniques for using labeled data $(X_1,Y_1),\ldots,(X_n,Y_n)$ together with unlabeled data $X_{n+1},\ldots,X_N$ to make predictions. These methods invoke some assumptions that link the marginal distribution $P_X$ of X to the regression function f(x). For example, it is common to assume that f is very smooth over high density regions of $P_X$. Many of the methods are ad-hoc and have been shown to work in specific examples but are lacking a theoretical foundation. We provide a minimax framework for analyzing semisupervised methods. In particular, we study methods based on metrics that are sensitive to the distribution $P_X$. Our model includes a parameter $α$ that controls the strength of the semisupervised assumption. We then use the data to adapt to $α$.
description: Published in at http://dx.doi.org/10.1214/13-AOS1092 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
FDI Protectionism Is on the Rise
Creators: name: Sauvant, Karl P.
Publisher: name: Columbia University
Year: 2009
Subjects: International relations
Investments, Foreign
Investments, Foreign--Law and legislation
Investments, Foreign--Government policy

description: Over the past two decades or so, countries have liberalized their FDI regulatory frameworks and have put in place an international investment law regime that provides various protections for international investors. In the past few years, however, there are signs that countries are reevaluating their approach toward such investment. As a result, FDI protectionism is on the rise, with screening of inward M&As becoming more frequent. Typically, this is being done under the guise of "national interest" or similar concepts, often linked to strategic sectors and national champions. While the international investment law regime faces a challenge to find the right balance between the rights and responsibilities of governments and investors, care needs to be taken that the rise of FDI protectionism does not endanger a rules-based approach to FDI. An independent FDI Protectionism Observatory to monitor new protectionist measures and name and shame countries that take them is therefore needed.
Antipersistent dynamics in kinetic models of wealth exchange
Creators: name: Goswami, Sanchari
name: Chatterjee, Arnab
name: Sen, Parongama
Publisher: name: arXiv
Year: 2011
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate the detailed dynamics of gains and losses made by agents in some kinetic models of wealth exchange. The concept of a walk in an abstract gain-loss space for the agents had been introduced in an earlier work. For models in which agents do not save, or save with uniform saving propensity, this walk has diffusive behavior. In case the saving propensity $λ$ is distributed randomly ($0 \leq λ< 1$), the resultant walk showed a ballistic nature (except at a particular value of $λ^* \approx 0.47$). Here we consider several other features of the walk with random $λ$. While some macroscopic properties of this walk are comparable to a biased random walk, at microscopic level, there are gross differences. The difference turns out to be due to an antipersistent tendency towards making a gain (loss) immediately after making a loss (gain). This correlation is in fact present in kinetic models without saving or with uniform saving as well, such that the corresponding walks are not identical to ordinary random walks. In the distributed saving case, antipersistence occurs with a simultaneous overall bias.
description: 8 pages revtex4
Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Creators: name: Moise, Nathalie
name: Khodneva, Yulia
name: Richman, Joshua
name: Shimbo, Daichi
name: Kronish, Ian M.
name: Safford, Monika M.
Publisher: name: Columbia University
Year: 2016
Subjects: Depression, Mental
Cardiology
Coronary heart disease
Coronary heart disease--Psychological aspects
Health and race
Cerebrovascular disease
Cerebrovascular disease--Risk factors
Cerebrovascular disease--Psychological aspects

description: Background Depression is a relapsing and remitting disease. Prior studies on the association between depressive symptoms and incident cardiovascular disease (CVD) have been limited by single measurements, and few if any have examined both incident coronary heart disease and stroke in a large biracial national cohort. We aimed to assess whether time‐dependent depressive symptoms conferred increased risk of incident CVD.

Methods and Results Between 2003 to 2007, 22 666 black and white participants (aged ≥45 years) without baseline CVD in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were recruited. Cox proportional hazards regression analyses assessed the association between up to 3 measurements of elevated depressive symptoms (4‐item Center for Epidemiologic Studies Depression Scale score ≥4) and incident coronary heart disease, stroke, and CVD death adjusting for age, sex, region, income, health insurance, education, blood pressure, cholesterol, medication, obesity, diabetes mellitus, kidney disease, C‐reactive protein, corrected QT interval, atrial fibrillation, left ventricular hypertrophy, smoking, alcohol, physical inactivity, medication adherence, and antidepressant use. The participants’ average age was 63.4 years, 58.8% were female, and 41.7% black. Time‐varying depressive symptoms were significantly associated with CVD death (adjusted hazard ratio 1.30, 95% CI 1.04–1.63), with a trend toward significance for fatal and nonfatal stroke (adjusted hazard ratio 1.26, 95% CI 0.99–1.60) but not fatal and nonfatal coronary heart disease (adjusted hazard ratio 1.11, 95% CI 0.89–1.38). Race did not moderate the association between depressive symptoms and CVD.

Conclusions Proximal depressive symptoms were associated with incident fatal and nonfatal stroke and CVD death even after controlling for multiple explanatory factors, further supporting the urgent need for timely management of depressive symptoms.
Measurement-device-independent quantum key distribution
Creators: name: Lo, Hoi-Kwong
name: Curty, Marcos
name: Qi, Bing
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: How to remove detector side channel attacks has been a notoriously hard problem in quantum cryptography. Here, we propose a simple solution to this problem---*measurement* device independent quantum key distribution. It not only removes all detector side channels, but also doubles the secure distance with conventional lasers. Our proposal can be implemented with standard optical components with low detection efficiency and highly lossy channels. In contrast to the previous solution of full device independent QKD, the realization of our idea does not require detectors of near unity detection efficiency in combination with a qubit amplifier (based on teleportation) or a quantum non-demolition measurement of the number of photons in a pulse. Furthermore, its key generation rate is many orders of magnitude higher than that based on full device independent QKD. The results show that long-distance quantum cryptography over say 200km will remain secure even with seriously flawed detectors.
description: 7 pages, two-column format, 4 figures in total
Supplementary Material from The origins and spread of the opium poppy (Papaver somniferum L.) revealed by genomics and seed morphometrics
Creators: name: Machado, Rui
name: Bonhomme, Vincent
name: Soteras, Raül
name: Jeanty, Angele
name: Bouby, Laurent
name: Evin, Allowen
name: Fernandes Martins, M. Joao
name: Gonçalves, Sandra
name: Antolín, Ferran
name: Salavert, Aurélie
name: Oliveira, Hugo Rafael Cardoso
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 310899
subject: Plant biology not elsewhere classified

description: ESM9_GWAS_GLM_MLM_WildVsDom_Poppy.pdf
Advanced Monte Carlo methods for pricing Bermudan options and their applications in real options analysis
Creators: name: Zhu, Jie
Publisher: name: Macquarie University
Year: 2022
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: Pricing options with early exercise features is a challenging problem in mathematical finance. There is no general closed-form solutions available. We have implemented three established Monte Carlo methods in R for pricing Bermudan options: the random tree method, the stochastic mesh method and the least-squares Monte Carlo method (LSMC). We have also adopted the expectation-maximization (EM) control algorithm recently pro- posed in the literature and adapted this method for pricing Bermudan options. The numerical analyses find LSMC has the best performance; and have been extended to the improvements on LSMC via considering regression schemes such as piecewise linear regression and smoothing splines, random number generating process using low-discrepancy sequences and the usage of European options as control variates. The algorithm has also been applied to study a standard real option problem, the option to delay an investment project. The implemented algorithm is a powerful tool to solve many important application problems of decision under uncertainty in realistic settings that can be considered in further research.
Ambulatory blood pressure monitoring phenotypes among individuals with and without diabetes taking antihypertensive medication: the Jackson Heart Study
Creators: name: Bromfield, Samantha G.
name: Shimbo, Daichi
name: Bertoni, Alain G.
name: Sims, Mario
name: Carson, April P.
name: Muntner, Paul
Publisher: name: Columbia University
Year: 2016
Subjects: Ambulatory blood pressure monitoring
Cardiology
Hypertension
Hypotensive agents
Diabetes

description: Ambulatory blood pressure monitoring (ABPM) can detect phenotypes associated with increased cardiovascular disease (CVD) risk. Diabetes is associated with increased CVD risk but few data are available documenting whether blood pressure (BP) phenotypes, detected by ABPM, differ between individuals with versus without diabetes. We conducted a cross-sectional analysis of 567 participants in the Jackson Heart Study, a population-based study of African Americans, taking antihypertensive medication to evaluate the association between diabetes and ABPM phenotypes. Two clinic BP measurements were taken at baseline following a standardized protocol. ABPM was performed for 24 h following the clinic visit. ABPM phenotypes included daytime, sustained, nocturnal and isolated nocturnal hypertension, a non-dipping BP pattern, and white coat, masked and masked isolated nocturnal hypertension. Diabetes was defined as fasting glucose greater than or equal to126 mg dl−1, haemoglobin A1c greater than or equal to6.5% (48 mmol mol−1) or use of insulin or oral hypoglycaemic medications. Of the included participants (mean age 62.3 years, 71.8% female), 196 (34.6%) had diabetes. After multivariable adjustment, participants with diabetes were more likely to have daytime hypertension (prevalence ratio (PR): 1.32; 95% confidence interval (CI): 1.09–1.60), masked hypertension (PR: 1.46; 95% CI: 1.11–1.93) and masked isolated nocturnal hypertension (PR: 1.39; 95% CI: 1.02–1.89). Although nocturnal hypertension was more common among participants with versus without diabetes, this association was not present after adjustment for daytime systolic BP. Diabetes was not associated with the other ABPM phenotypes investigated. This study highlights the high prevalence of ABPM phenotypes among individuals with diabetes taking antihypertensive medication.
Dimensional-crossover-driven Mott transition in the frustrated Hubbard model
Creators: name: Raczkowski, Marcin
name: Assaad, Fakher F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the Mott transition in a frustrated Hubbard model with next-nearest neighbor hopping at half-filling. The interplay between interaction, dimensionality and geometric frustration closes the one-dimensional Mott gap and gives rise to a metallic phase with Fermi surface pockets. We argue that they emerge as a consequence of remnant one-dimensional Umklapp scattering at the momenta with vanishing interchain hopping matrix elements. In this pseudogap phase, enhanced d-wave pairing correlations are driven by antiferromagnetic fluctuations. Within the adopted cluster dynamical mean-field theory on the $8\times 2$ cluster and down to our lowest temperatures the transition from one to two dimensions is continuous.
description: 5 pages, 8 figures, extended by data on the 4x4 cluster
Additional file 1: of Driving following defibrillator implantation: development and pilot results from a nationwide questionnaire
Creators: name: Bjerre, Jenny
name: Rosenkranz, Simone
name: Christensen, Anne
name: Schou, Morten
name: JĂ¸ns, Christian
name: Gislason, Gunnar
name: Ruwald, Anne-Christine
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Table S1. Questionnaire Conceptualization Process: The research aims, hypotheses, concepts and corresponding variable definitions [7â 12, 19, 29â 33]. (DOCX 90 kb)
Radiation hydrodynamics of triggered star formation: the effect of the diffuse radiation field
Creators: name: Haworth, Thomas J.
name: Harries, Tim J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the effect of including diffuse field radiation when modelling the radiatively driven implosion of a Bonnor-Ebert sphere (BES). Radiation-hydrodynamical calculations are performed by using operator splitting to combine Monte Carlo photoionization with grid-based Eulerian hydrodynamics that includes self-gravity. It is found that the diffuse field has a significant effect on the nature of radiatively driven collapse which is strongly coupled to the strength of the driving shock that is established before impacting the BES. This can result in either slower or more rapid star formation than expected using the on-the-spot approximation depending on the distance of the BES from the source object. As well as directly compressing the BES, stronger shocks increase the thickness and density in the shell of accumulated material, which leads to short, strong, photo-evaporative ejections that reinforce the compression whenever it slows. This happens particularly effectively when the diffuse field is included as rocket motion is induced over a larger area of the shell surface. The formation and evolution of 'elephant trunks' via instability is also found to vary significantly when the diffuse field is included. Since the perturbations that seed instabilities are smeared out elephant trunks form less readily and, once formed, are exposed to enhanced thermal compression.
description: Accepted for publication in MNRAS. 19 pages, 14 figures, 8 tables
Salary Negotiation for Social Workers: A mini-workshop
Creators: name: Marquart, Matthea S.
Publisher: name: Columbia University
Year: 2017
Subjects: Collective bargaining
Job hunting
Vocational guidance
Social workers--Vocational guidance

description: Workshop at Columbia University School of Social Work’s 2017 Community Day, on March 27, 2017. Part of the session on Gender Pay Equity and Salary Negotiation, sponsored by the Social Work Administration and Management (SWAM) student caucus.
Experimental fully contextual correlations
Creators: name: Amselem, Elias
name: Danielsen, Lars Eirik
name: Lopez-Tarrida, Antonio J.
name: Portillo, Jose R.
name: Bourennane, Mohamed
name: Cabello, Adan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum correlations are contextual yet, in general, nothing prevents the existence of even more contextual correlations. We identify and test a noncontextuality inequality in which the quantum violation cannot be improved by any hypothetical postquantum theory, and use it to experimentally obtain correlations in which the fraction of noncontextual correlations is less than 0.06. Our correlations are experimentally generated from the results of sequential compatible tests on a four-state quantum system encoded in the polarization and path of a single photon.
description: REVTeX4, 6 pages, 3 figures
Topological chiral magnonic edge mode in a magnonic crystal
Creators: name: Shindou, Ryuichi
name: Matsumoto, Ryo
name: Murakami, Shuichi
name: Ohe, Jun-ichiro
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Topological phases have been explored in various fields in physics such as spintronics, photonics, liquid helium, correlated electron system and cold-atomic system. This leads to the recent foundation of emerging materials such as topological band insulators, topological photonic crystals and topological superconductors/superfluid. In this paper, we propose a topological magnonic crystal which provides protected chiral edge modes for magnetostatic spin waves. Based on a linearized Landau-Lifshitz equation, we show that a magnonic crystal with the dipolar interaction acquires spin-wave volume-mode band with non-zero Chern integer. We argue that such magnonic systems are accompanied by the same integer numbers of chiral spin-wave edge modes within a band gap for the volume-mode bands. In these edge modes, the spin wave propagates in a unidirectional manner without being scattered backward, which implements novel fault-tolerant spintronic devices.
description: 12 pages, 7 figures
title: Gerhard Cornelius von Driesch
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Gerhard Cornelius von Driesch as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
title: Charles Dufresne sieur Du Cange
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Charles Dufresne sieur Du Cange as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Ambulatory Blood Pressure Control and Subclinical Left Ventricular Dysfunction in Treated Hypertensive Subjects
Creators: name: Sera, Fusako
name: Jin, Zhezhen
name: Russo, Cesare
name: Lee, Edward S.
name: Schwartz, Joseph E.
name: Rundek, Tatjana
name: Elkind, Mitchell S.
name: Homma, Shunichi
name: Sacco, Ralph L.
name: Di Tullio, Marco R.
Publisher: name: Columbia University
Year: 2015
Subjects: Hypertension
Blood pressure--Regulation
Heart--Left ventricle
Ambulatory blood pressure monitoring

description: Blood pressure (BP) control in hypertensive patients is crucial for reducing the risk of heart failure development and may be particularly important in elderly subjects, who have an especially high prevalence of hypertension and risk of heart failure (1). Left ventricular (LV) global longitudinal strain (GLS) is an echocardiographic measure of LV systolic function that can be an indicator of early subclinical cardiac dysfunction, even when LV ejection fraction is normal. The association of BP control with early subclinical LV dysfunction according to GLS has not been extensively studied, and it is also unknown whether assessing BP control with ambulatory blood pressure (ABP) monitoring is superior to using office BP measurements in this regard. Therefore, we investigated the association of BP control with GLS by using ABP and office BP criteria in a community-based, predominantly elderly cohort with normal LV ejection fraction.
title: Jean-Baptiste Du Hamel
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Jean-Baptiste Du Hamel as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Photoemission Spectroscopy and the Unusually Robust One Dimensional Physics of Lithium Purple Bronze
Creators: name: Dudy, L.
name: Denlinger, J. D.
name: Allen, J. W.
name: Wang, F.
name: He, J.
name: Hitchcock, D.
name: Sekiyama, A.
name: Suga, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Temperature dependent photoemission spectroscopy in Li0.9Mo6O17 contributes to evidence for one dimensional physics that is unusually robust. Three generic characteristics of the Luttinger liquid are observed, power law behavior of the k-integrated spectral function down to temperatures just above the superconducting transition, k-resolved lineshapes that show holon and spinon features, and quantum critical (QC) scaling in the lineshapes. Departures of the lineshapes and the scaling from expectations in the Tomonaga Luttinger model can be partially described by a phenomenological momentum broadening that is presented and discussed. The possibility that some form of 1d physics obtains even down to the superconducting transition temperature is assessed.
description: submitted to JPCM, Special issue article "Physics in one dimension"
title: Charles François Caradas Du Héron
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Charles François Caradas Du Héron as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Understanding the Origins of a Pandemic Virus
Creators: name: Hernandez, Carlos Xavier
name: Chan, Joseph M.
name: Khiabanian, Hossein
name: Rabadan, Raul
Publisher: name: Columbia University
Year: 2011
Subjects: subject: Public health
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: Understanding the pre-pandemic conditions and the origin of infectious diseases provides scientifically based rationales for implementing public health measures that help to avoid, or at least to mitigate, future epidemics. The recent ancestors of a pandemic virus provide an invaluable information about the set of minimal genomic alterations that transformed a zoonotic agent into a full human pandemic. Since the first confirmed cases of the H1N1pdm virus in the spring of 2009 several hypotheses about the strain's origins have been proposed. However, how, where, and when it first infected humans is still far from clear. The only way to piece together such an epidemiological puzzle relies on the collective effort of the international scientific community to increase genomic sequencing of influenza isolates, especially ones collected in the months prior to the origin of the pandemic.
Latency-Sensitive Service Chaining with Security Isolation Constraints
Creators: name: Carlinet, Yannick
Publisher: name: Zenodo
Year: 2023

description: The envisioned requirements for 6G include, among others, lower environment impact, imperceptible end-to-end latency, high resiliency, security and privacy. They can only be achieved by combining both compute and communications capabilities of the whole network: core, edge, access. This is the reason why Multi-access Edge Computing (MEC) is one of the key enablers in 6G, by offering computing capabilities near the end users. This will enable the deployment of latency-sensitive services. However, deployment of services in the edge poses some security challenges. This work aims at solving orchestration issues, such as how to deal with service deployment while meeting service-specific requirements, while at the same time meeting security isolation requirements, in a multi-cluster environment. We could build an orchestration engine, with an advanced algorithm to compute optimal placement of micro-services, integrated in a state-of-art emulation platform with industry best practice. This demonstrates the feasibility in practice of our approach.
title: Johann Reinhold Dulsecker
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Johann Reinhold Dulsecker as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Regulation of primary, immortalized, and metatstatic human pancreatic ductal cells by insulin
Creators: name: Chan, Michelle Tsz Ting
Publisher: name: University of British Columbia
Year: 2013

description: Epidemiological studies have reported positive correlation between type 2 diabetes and risk of pancreatic cancer. Hyperinsulinemia occurring during early diabetes has been postulated to be a possible pathophysiological mechanism in promoting pancreatic cancer, but the mechanisms by which elevated insulin levels contribute to pancreatic carcinogenesis are still unknown. Here, the effects of insulin and its associated mechanism on cellular viability were examined in three cell models that are meant to represent three stages in pancreatic cancer progression. Furthermore, using small molecule inhibitors, the role of RAF/ERK pathway and PI3K/AKT pathway on cellular viability were also compared across three cell models. Different stages of pancreatic cancer progression were modeled in vitro with primary human pancreatic ductal cells, an immortalized pre-malignant human pancreatic ductal cell line (HPDE), and an advanced metastatic human pancreatic adenocarcinoma cell line (PANC1). All cell types were serum starved and treated with insulin, IGF1, or small molecule inhibitors targeting RAF1, MEK, AKT, or PI3K, then subjected to cell viability assays, cell death assays, and Western blot analysis for ERK and AKT activation. We observed that cell viability was promoted by exogenous insulin in PANC1 cells, and not in primary cells. In PANC1 cells, the insulin-mediated enhancement of cell viability was associated with sustained AKT activation. Furthermore, insulin-mediated reduction in cell death was not observed. When comparing the roles of RAF/ERK and PI3K/AKT pathways on cell viability, we observed an increase in cell death in primary cells when AKT was inhibited. In contrast, cell death was induced in HPDE and PANC1 cells when the RAF1 or MEK were inhibited. If extrapolated, the data suggest that hyperinsulinemia may not play a role in initiating pancreatic cancer, but high levels of insulin may accelerate the cancer progression.
Calabi-Yau Manifolds, Hermitian Yang-Mills Instantons and Mirror Symmetry
Creators: name: Yang, Hyun Seok
name: Yun, Sangheon
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We address the issue why Calabi-Yau manifolds exist with a mirror pair. We observe that the irreducible spinor representation of the Lorentz group Spin(6) requires us to consider the vector spaces of two-forms and four-forms on an equal footing. The doubling of the two-form vector space due to the Hodge duality doubles the variety of six-dimensional spin manifolds. We explore how the doubling is related to the mirror symmetry of Calabi-Yau manifolds. Via the gauge theory formulation of six-dimensional Riemannian manifolds, we show that the curvature tensor of a Calabi-Yau manifold satisfies the Hermitian Yang-Mills equations on the Calabi-Yau manifold. Therefore the mirror symmetry of Calabi-Yau manifolds can be recast as the mirror pair of Hermitian Yang-Mills instantons. We discuss the mirror symmetry from the gauge theory perspective.
description: v5; 49 pages, version to appear in Advances in High Energy Physics
The CAPE (Caribbean Advance Proficiency Examination) Approach to Mathematics
Creators: name: Charles, Abigail S.
Publisher: name: Columbia University
Year: 2010
Subjects: Educational evaluation
Mathematics--Study and teaching
Public policy (Law)

description: The transition process from the General Certificate of Education (GCE) Advanced Level Examinations, to the Caribbean Advanced Proficiency Examination (CAPE) that began in 1998, is still rife with discussion from students, teachers and policy makers.  Policy makers are interested in having a uniform examination system that is suitably rigorous to test Mathematical concepts for entering the tertiary level, while also having the cultural stamp that distinguishes it from the previous system under the British rule. Teachers are interested in the receiving suitable professional development in order teach the new format of materials. They are also concerned about the timeframe in which the allotted material ought to be taught and absorbed before the exams are taken. Students are parochially interested in learning the material in order to pass the examination. Given these three positions of major stakeholders, a detailed tour of the structure of the CAPE Mathematics curriculum will be explored in this article.
How much H and He is "hidden" in SNe Ib/c? I. - low-mass objects
Creators: name: Hachinger, S.
name: Mazzali, P. A.
name: Taubenberger, S.
name: Hillebrandt, W.
name: Nomoto, K.
name: Sauer, D. N.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: H and He features in photospheric spectra have seldom been used to infer quantitatively the properties of Type IIb, Ib and Ic supernovae (SNe IIb, Ib and Ic) and their progenitor stars. Most radiative transfer models ignored NLTE effects, which are extremely strong especially in the He-dominated zones. In this paper, a comprehensive set of model atmospheres for low-mass SNe IIb/Ib/Ic is presented. Long-standing questions such as how much He can be contained in SNe Ic, where He lines are not seen, can thus be addressed. The state of H and He is computed in full NLTE, including the effect of heating by fast electrons. The models are constructed to represent iso-energetic explosions of the same stellar core with differently massive H/He envelopes on top. The synthetic spectra suggest that 0.06 - 0.14 M_sun of He and even smaller amounts of H suffice for optical lines to be present, unless ejecta asymmetries play a major role. This strongly supports the conjecture that low-mass SNe Ic originate from binaries where progenitor mass loss can be extremely efficient.
description: 19 pages, 12 figures. Published in MNRAS. V2 with corrections and additional references