cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Ernst August von Braunschweig-Lüneburg-Hannover
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Ernst August von Braunschweig-Lüneburg-Hannover as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from Southern Africa
Creators: name: Briese, Thomas
name: Paweska, Janusz T.
name: McMullan, Laura K.
name: Hutchison, Stephen K.
name: Street, Craig
name: Palacios, Gustavo F.
name: Khristova, Marina L.
name: Weyer, Jacqueline
name: Swanepoel, Robert
name: Egholm, Michael
name: Nichol, Stuart T.
name: Lipkin, W. Ian
Publisher: name: Columbia University
Year: 2009
Subjects: Epidemiology
Virology

description: Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases). Unbiased pyrosequencing of RNA extracts from serum and tissues of outbreak victims enabled identification and detailed phylogenetic characterization within 72 hours of sample receipt. Full genome analyses of LUJV showed it to be unique and branching off the ancestral node of the Old World arenaviruses. The virus G1 glycoprotein sequence was highly diverse and almost equidistant from that of other Old World and New World arenaviruses, consistent with a potential distinctive receptor tropism. LUJV is a novel, genetically distinct, highly pathogenic arenavirus.
Neomeschia queenslandensis Malipatil 2014
Creators: name: Malipatil, M. B.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Meschiidae
Neomeschia
Neomeschia queenslandensis

description: Neomeschia queenslandensis Malipatil, 2014 (Figs. 1–4, 10) Neomeschia queenslandensis Malipatil, 2014: 244–246. Specimen examined: 1 male, Australia, Queensland, 28.03°S 153.07°E, ‘ Glen Witheren’, general, 26–29.xii.2001, MV light 10352, G.B. Monteith (QM). Redescription. Following are additions to the original description provided by Malipatil (2014): Body (Fig. 1) length including wings 6.30; maximum width 2.30. Head (Fig. 4) length 1.25; width across eyes 1.71; interocular space 1.14; interocellar space 0.60; eye-ocellar space 0.30; eye length 0.38; eye width 0.30. Length of labial segments: I 1.21; II 1.33; III 1.25; IV 1.29. Length of labrum 0.30. Length of antennal segments (Fig. 3): I 0.49; II 1.71; III 1.25; IV 1.44. Thorax: Pronotum (Fig. 4) median length 1.25; width at anterior margin 1.25; width at posterior margin 2.28. Scutellum length 1.14; width 1.35. Length of hemelytra 3.80; length of corium 2.85; claval commissure 0.41. Abdomen: (Fig. 2) Details of spiracles, punctures, and scent gland scars as in genus description. Male genitalia: Pygophore produced apically to a conical process directed slightly postero-ventrally, entire exposed surface finely punctate. Paramere (Fig. 10) with blade broad in middle and gradually narrowed and truncate apically, basal part with inner margin not produced but with several erect setae. Aedeagus details similar to in N. minuta sp. nov. provided below.
description: Published as part of Malipatil, M. B., 2021, Neomeschia minuta sp. nov. from Australia (Hemiptera: Heteroptera: Meschiidae), pp. 447-450 in Zootaxa 5032 (10) on page 447, DOI: 10.11646/zootaxa.5032.3.10, http://zenodo.org/record/5497920
description: {"references": ["Malipatil, M. B. (2014) Meschiidae, a new family of Lygaeoidea (Hemiptera: Heteroptera) from India and Australia, with descriptions of a new genus and two new species. Zootaxa, 3815 (2), 233 - 248. https: // doi. org / 10.11646 / zootaxa. 3815.2.4"]}
title: Ernst von Hessen-Rheinfels
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Ernst von Hessen-Rheinfels as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
On the Quiver Presentation of the Descent Algebra of the Symmetric Group
Creators: name: Bishop, Marcus
name: Pfeiffer, Götz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Group Theory (math.GR)
subject: Combinatorics (math.CO)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 16G20, 20F55

description: We describe a presentation for the descent algebra of the symmetric group $\sym{n}$ as a quiver with relations. This presentation arises from a new construction of the descent algebra as a homomorphic image of an algebra of forests of binary trees which can be identified with a subspace of the free Lie algebra. In this setting, we provide a new short proof of the known fact that the quiver of the descent algebra of $\sym{n}$ is given by restricted partition refinement. Moreover, we describe certain families of relations and conjecture that for fixed $n\in\mathbb{N}$, the finite set of relations from these families that are relevant for the descent algebra of $\sym{n}$ generates the ideal of relations, and hence yields an explicit presentation by generators and relations of the algebra.
description: Final version; 21 pages
MOESM5 of Impact of rare and low-frequency sequence variants on reliability of genomic prediction in dairy cattle
Creators: name: Zhang, Qianqian
name: Sahana, Goutam
name: Su, Guosheng
name: Guldbrandtsen, Bernt
name: Lund, Mogens
name: Calus, Mario
Publisher: name: figshare
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 5: Table S5. Proportion of rare or low-frequency variants (RLFV)a segregating both in the validation and training populations from different models using various marker sets for fertility, health and longevity.
Phylogenetic analysis of a human isolate from the 2000 Israel West Nile virus epidemic
Creators: name: Briese, Thomas
name: Rambaut, Andrew
name: Weinberger, Miriam
name: Bishara, Jihad
name: Pathmajeyan, Melissa
name: Pitlik, Silvio
name: Lipkin, W. Ian
Publisher: name: Columbia University
Year: 2002
Subjects: Epidemiology
Virology
West Nile virus

description: Specimens from a patient of the 2000 Israel West Nile virus epidemic were analyzed by reverse transcription-polymerase chain reaction. Products corresponding to E, NS3, and NS5 sequences were amplified from cerebellar but not from cortical samples. Phylogenetic analyses indicated a closer relationship of this isolate to 1996 Romanian and 1999 Russian than to 1998-99 Israeli or 1999 New York isolates.
Environmental epidemiology of essential tremor
Creators: name: Louis, Elan D.
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Essential tremor (ET) is one of the most common neurological disorders. Despite this, the disease mechanisms and etiology are not well understood. While susceptibility genotypes undoubtedly underlie many ET cases, no ET genes have been identified thus far. As with many other progressive, degenerative neurological disorders, it is likely that environmental factors contribute to the etiology of ET. Environmental epidemiology is the study in specific populations or communities of the effect on human health of physical, biologic and chemical factors in the external environment. The purpose of this article is to review current knowledge with regards to the environmental epidemiology of ET. Results: As will be discussed, a series of preliminary case-control studies in recent years has begun to explore several candidate toxins/exposures, including harmane (1-methyl-9H-pyrido[3,4-b]indole), lead and agricultural exposures/pesticides. Conclusions: While several initial results are promising, as will be discussed, additional studies are needed to more definitively establish whether these exposures are associated with ET and if they are of etiological importance.
Quasi-classical trajectories study of Ne2Br2(B) vibrational predissociation: Kinetics and product distributions
Creators: name: Arbelo-González, Wilmer
name: González-Martínez, Maykel L.
name: Reed, Stewart K.
name: Rubayo-Soneira, Jesús
name: Shalashilin, Dmitrii V.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: The vibrational predissociation of the Ne2Br2(B) van der Waals complex has been investigated using the quasi-classical trajectory method (QCT), in the range of vibrational levels v' = 16-23. Extensive comparison is made with the most recent experimental observations [Pio et al., J. Chem. Phys. 133, 014305 (2010)], molecular dynamics with quantum transitions (MDQT) simulations [Miguel et al., Faraday Discuss. 118, 257 (2001)], and preliminary results from 24-dimensional Cartesian coupled coherent state (CCCS) calculations. A sequential mechanism is found to accurately describe the theoretical dynamical evolution of intermediate and final product populations, and both QCT and CCCS provide very good estimates for the dissociation lifetimes. The capabilities of QCT in the description of the fragmentation kinetics is analyzed in detail by using reduced-dimensionality models of the complexes and concepts from phase-space transport theory. The problem of fast decoupling of the different coherent states in CCCS simulations, resulting from the high dimensionality of phase space, is tackled using a re-expansion scheme. QCT ro-vibrational product state distributions are reported. Due to the weakness of the vdW couplings and the low density of vibrational states, QCT predicts a larger than observed propensity for Δv' = -1 and -2 channels for the respective dissociation of the first and second Ne atoms.
description: 16 pages, 6 figures, 4 tables. Accepted for publication in J. Chem. Phys
Multi-Dimensional Time-Series Shapelet Based Real-Time Fault Detection and Localization on ISS Electrical Power Distribution System
Creators: Qin Liu, Weiran Chen, Venkata Dinavahi
Publisher: name: University of Alberta Library
Year: 2024

International space station (ISS) is a grand invention for human beings to have a chance at exploring the outer space. Its operation is completely dependent on the autonomous power distribution system which transforms energy by solar arrays from the sun. There is a high demand for a reliable monitoring system that can accurately and timely detect and localize faults in its power system for the special working environment of the ISS. In this paper, a fault detection and localization (FDL) based on multi-dimensional time-series trend extracted shapelet (MTES) method was proposed. A fast shapelet discovery was created to accelerate the process of extracting shape features from timeseries signals collected from the ISS electrical power distribution system (EPDS). Then the techniques of randomization and information gain were exploited for the further shapelet selection. Finally, multi-dimensional time-series classification for FDL was solved by a designed random forest classifier. The real-time FDL measurement instrument was emulated on the Xilinxr VCU128 FPGA board, while a hardware-in-the-loop (HIL) testing platform was established to verify the effectiveness, execution speed, and accuracy of the MTES method. Comparing with other state-of-the-art data-driven methods, higher accuracy (above 96%) and easier hardware implementation were achieved using MTES.
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor
Creators: name: Louis, Elan D.
name: Jiang, Wendy
name: Pellegrino, Kathryn M.
name: Rios, Eileen
name: Factor-Litvak, Pam
name: Henchcliffe, Claire
name: Zheng, Wei
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors likely play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin. In 2002, we demonstrated elevated blood harmane concentrations in an initial sample of 100 ET cases compared to 100 controls. Between 2002 and 2007, we assembled a new and larger sample of ET cases and controls. We now attempt to replicate our previous findings. Cases and controls were frequency-matched on age, gender, and race. Blood harmane concentrations were quantified by high-performance liquid chromatography. Subjects comprised 150 ET cases and 135 controls (mean age 65.3 ± 15.5 vs. 65.5 ± 14.2 years, p = 0.94). Mean log blood harmane concentration was ∼50% higher in cases than controls (0.50 ± 0.54 g−10/ml vs. 0.35 ± 0.62 g−10/ml, p = 0.038). In a logistic regression analysis, log blood harmane concentration was associated with ET (ORadjusted 1.56, 95% CI 1.01–2.42, p = 0.04), and odds of ET was 1.90 (95% CI 1.07–3.39, p = 0.029) in the highest versus lowest log blood harmane tertile. Log blood harmane was highest in ET cases with familial ET (0.53 ± 0.57 g−10/ml), intermediate in cases with sporadic ET (0.43 ± 0.45 g−10/ml) and lowest in controls (0.35 ± 0.62 g−10/ml) (test for trend, p = 0.026). Blood harmane appears to be elevated in ET. The higher concentrations in familial ET suggests that the mechanism may involve genetic factors.
MOESM6 of Impact of rare and low-frequency sequence variants on reliability of genomic prediction in dairy cattle
Creators: name: Zhang, Qianqian
name: Sahana, Goutam
name: Su, Guosheng
name: Guldbrandtsen, Bernt
name: Lund, Mogens
name: Calus, Mario
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 6: Table S6. The additive genetic variances explained in the models for one replicate (the same replicate as selected for TablesÂ 4, 5 and 6) in each simulation scenario and different strategies for selection of rare and low-frequency variants (RLFV).
Dynamics of Teleparallel Dark Energy
Creators: name: Wei, Hao
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recently, Geng et al. proposed to allow a non-minimal coupling between quintessence and gravity in the framework of teleparallel gravity, motivated by the similar one in the framework of General Relativity (GR). They found that this non-minimally coupled quintessence in the framework of teleparallel gravity has a richer structure, and named it "teleparallel dark energy". In the present work, we note that there might be a deep and unknown connection between teleparallel dark energy and Elko spinor dark energy. Motivated by this observation and the previous results of Elko spinor dark energy, we try to study the dynamics of teleparallel dark energy. We find that there exist only some dark-energy-dominated de Sitter attractors. Unfortunately, no scaling attractor has been found, even when we allow the possible interaction between teleparallel dark energy and matter. However, we note that $w$ at the critical points is in agreement with observations (in particular, the fact that $w=-1$ independently of $ξ$ is a great advantage).
description: 14 pages, 4 tables, revtex4; v2: discussions added, Phys. Lett. B in press; v3: published version
Nonequilibrium thermodynamics as a gauge theory
Creators: name: Polettini, Matteo
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We assume that markovian dynamics on a finite graph enjoys a gauge symmetry under local scalings of the probability density, derive the transformation law for the transition rates and interpret the thermodynamic force as a gauge potential. A widely accepted expression for the total entropy production of a system arises as the simplest gauge-invariant completion of the time derivative of Gibbs's entropy. We show that transition rates can be given a simple physical characterization in terms of locally-detailed-balanced heat reservoirs. It follows that Clausius's measure of irreversibility along a cyclic transformation is a geometric phase. In this picture, the gauge symmetry arises as the arbitrariness in the choice of a prior probability. Thermostatics depends on the information that is disposable to an observer; thermodynamics does not.
description: 6 pages. Non-fatal errors in eq.(6), eq.(26) and eq.(31) have been amended
Philadelphia Geriatric Morale Scale in essential tremor : a population-based study in three Spanish communities
Creators: name: Louis, Elan D.
name: Benito-Leon, Julian
name: Bermejo-Pareja, Felix
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Essential tremor (ET) is associated with both functional disability and depression. Each could contribute to a poor sense of well-being and low morale. We hypothesized that morale would be lower in ET cases than controls. Using a population-based, cross-sectional design, morale was assessed in 187 ET cases and 561 matched controls living in three communities in central Spain using the Philadelphia Geriatric Center Morale Scale (PGCMS) (range = 0 [low morale]-17), which included three-dimensions of psychological well-being: agitation, lonely dissatisfaction, and attitude toward own aging. The PGCMS score was lower in ET cases than controls (9.41 ± 3.21 vs. 10.39 ± 2.92, P < 0.001), as were the Agitation subscore (3.17 ± 1.71 vs. 3.78 ± 1.67, P < 0.001) and Lonely Dissatisfaction subscore (3.75 ± 1.34 vs. 4.02 ± 1.24, P < 0.05). Nearly one-half of the ET cases were classified as having low morale compared with only one-third of controls (P = 0.006). In a linear regression analysis adjusting for demographic factors and multiple comorbid conditions, ET cases had a lower log PGCMS score than controls (P < 0.001). Exclusion of participants on antidepressant medication did not change the results. Our results indicate that morale is significantly lower in community-dwelling ET cases than in matched controls. This lower morale could in part be a proxy for mild, untreated depression. It therefore seems important to detect and then possibly treat this problem to improve the psychological well-being of patients with this disease.
A 5d/3d duality from relativistic integrable system
Creators: name: Chen, Heng-Yu
name: Hollowood, Timothy J.
name: Zhao, Peng
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose and prove a new exact duality between the F-terms of supersymmetric gauge theories in five and three dimensions with adjoint matter fields. The theories are compactified on a circle and are subject to the Omega deformation. In the limit proposed by Nekrasov and Shatashvili, the supersymmetric vacua become isolated and are identified with the eigenstates of a quantum integrable system. The effective twisted superpotentials are the Yang-Yang functional of the relativistic elliptic Calogero-Moser model. We show that they match on-shell by deriving the Bethe ansatz equation from the saddle point of the five-dimensional partition function. We also show that the Chern-Simons terms match and extend our proposal to the elliptic quiver generalizations.
description: 30 pages, 4 figures. v2: typo corrected, references added
RNA viruses in hymenopteran pollinators : evidence of inter-taxa virus transmission via pollen and potential impact on non-Apis hymenopteran species
Creators: name: Singh, Rajwinder
name: Levitt, Abby L.
name: Rajotte, Edwin G.
name: Holmes, Edward C.
name: Ostiguy, Nancy
name: VanEngelsdorp, Dennis
name: Lipkin, W. Ian
name: DePamphilis, Claude W.
name: Toth, Amy L.
name: Cox-Foster, Diana L.
Publisher: name: Columbia University
Year: 2010
Subjects: Epidemiology
Virology

description: Although overall pollinator populations have declined over the last couple of decades, the honey bee (Apis mellifera) malady, colony collapse disorder (CCD), has caused major concern in the agricultural community. Among honey bee pathogens, RNA viruses are emerging as a serious threat and are suspected as major contributors to CCD. Recent detection of these viral species in bumble bees suggests a possible wider environmental spread of these viruses with potential broader impact. It is therefore vital to study the ecology and epidemiology of these viruses in the hymenopteran pollinator community as a whole. We studied the viral distribution in honey bees, in their pollen loads, and in other non-Apis hymenopteran pollinators collected from flowering plants in Pennsylvania, New York, and Illinois in the United States. Viruses in the samples were detected using reverse transcriptase-PCR and confirmed by sequencing. For the first time, we report the molecular detection of picorna-like RNA viruses (deformed wing virus, sacbrood virus and black queen cell virus) in pollen pellets collected directly from forager bees. Pollen pellets from several uninfected forager bees were detected with virus, indicating that pollen itself may harbor viruses. The viruses in the pollen and honey stored in the hive were demonstrated to be infective, with the queen becoming infected and laying infected eggs after these virus-contaminated foods were given to virus-free colonies. These viruses were detected in eleven other non-Apis hymenopteran species, ranging from many solitary bees to bumble bees and wasps. This finding further expands the viral host range and implies a possible deeper impact on the health of our ecosystem. Phylogenetic analyses support that these viruses are disseminating freely among the pollinators via the flower pollen itself. Notably, in cases where honey bee apiaries affected by CCD harbored honey bees with Israeli Acute Paralysis virus (IAPV), nearby non-Apis hymenopteran pollinators also had IAPV, while those near apiaries without IAPV did not. In containment greenhouse experiments, IAPV moved from infected honey bees to bumble bees and from infected bumble bees to honey bees within a week, demonstrating that the viruses could be transmitted from one species to another. This study adds to our present understanding of virus epidemiology and may help explain bee disease patterns and pollinator population decline in general.
A community driven initiative to crowdsource background details of 1,700 High Court Judges in India
Creators: name: Apoorv Anand
Publisher: name: Zenodo
Year: 2023
Subjects: judges
opendata
open justice
crowdsource
law and justice
csvconf

description: Slides from a presentation at csv,conf,v7 in Buenos Aires, Argentina. April 20th, 2023. The KHOJ (Know Your High Court Judges) dataset includes data of more than 1700 judges appointed between 1993 (after the creation of the collegium) and 2021. The dataset captures information across 43 variables including the personal, educational and professional background of India’s High Court judges. It opens pathways for researchers who are looking to probe deeper or wider into the composition of the High Courts and those who want to undertake jurimetrics studies which explore the linkage between judicial behaviour and the background of judges. The core philosophy behind building such a dataset is the realization that people of the country should have more information about judges whose decisions have a real impact on such people's lives. This dataset is the result of a joint effort over 15 months involving more than 30 students and 10 professionals who volunteered their time and efforts in preparing this dataset. This was a collaboration between NLUO’s Centre for Public Policy, Law and Good Governance, Agami and CivicDataLab. It started with the Summer of Data 2021 programme where students from across the country became the original data creators using official and publicly accessible data sources.
Emergence of Parkinson's disease in essential tremor : a study of the clinical correlates in 53 patients
Creators: name: Minen, Mia T.
name: Louis, Elan D.
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Patients with essential tremor (ET) may develop Parkinson's disease (PD); however, few studies have examined the clinical features of this combination syndrome. Fifty-three patients with ET-PD were studied and compared to 53 PD and 150 ET patients. Although the latency from onset of ET to PD was brief (< 5 years) in 38.5%, in a sizable proportion (30.8%), it was very long (> 20 years). The gender distribution of ET-PD (67.9% male) was identical to that of PD (67.9% male), yet differed from that of ET (50.0% male) (P = 0.02). The initial cardinal sign of PD was rest tremor in 100% of patients. In ET-PD, the side of greatest initial ET severity usually matched that of greatest PD severity (P < 0.05). In ET-PD, male gender predominated and the sidedness of the ET and PD usually matched. The co-occurrence of the two diagnoses in the same patient may be mechanistically related.
title: Huldreich von Eyben
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Huldreich von Eyben as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Autophagy inhibition and hypertonicity increased monoclonal antibody production in chinese hamster ovary fed-batch cultures
Creators: name: Nasseri, Sayyed Soroush
Publisher: name: University of British Columbia
Year: 2013

description: Biopharmaceuticals have improved the treatment of many diseases such as cancers and strokes, with much reduced adverse effects. However, high prices pose a major challenge to their widespread application. Improvements to cell culture processes can ease this burden, and facilitate the access to high quality biological medications for increasing sections of world society. This thesis addresses two methods to increase the productivity of the Chinese Hamster Ovary (CHO) cells expressing monoclonal antibodies using either autophagy inhibition or hypertonicity. Autophagy is a cellular process whereby intracellular components are degraded in response to nutrient limitations and other stresses. It has previously been shown that 3-methyladenine (3-MA) inhibition of autophagy can increase fed-batch tissue plasminogen activator production. This thesis investigated autophagy inhibition in fed-batch cultures of CHO cells producing monoclonal antibodies (MAb). Hypertonicity in mammalian cell cultures has also been shown to increase the MAb productivity of mammalian cell cultures. By investigating the timing and dose of 3-MA, more than two-fold increases in cell specific productivity and an up to two-fold increase in total MAb were obtained. Hypertonic conditions can similarly increase the productivity of fed-batch cultures by more than two-fold. The combination of these two approaches, however, did not result in any increase in productivity. Neither autophagy inhibition nor hypertonicity significantly changed the glycan profiles of the MAb product.
Shape-Wilf-equivalences for vincular patterns
Creators: name: Baxter, Andrew M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A05, 05A15, 05A19

description: We extend the notion of shape-Wilf-equivalence to vincular patterns (also known as "generalized patterns" or "dashed patterns"). First we introduce a stronger equivalence on patterns which we call filling-shape-Wilf-equivalence. When vincular patterns $α$ and $β$ are filling-shape-Wilf-equivalent, we prove that the direct sum $α\oplusσ$ is filling-shape-Wilf-equivalent to $β\oplusσ$. We also discover two new pairs of patterns which are filling-shape-Wilf-equivalent: when $α$, $β$, and $σ$ are nonempty consecutive patterns which are Wilf-equivalent, $α\oplusσ$ is filling-shape-Wilf-equivalent to $β\oplusσ$; and for any consecutive pattern $α$, $1\oplusα$ is filling-shape-Wilf-equivalent to $1\ominusα$. These equivalences generalize Wilf-equivalences found by Elizalde and Kitaev. These new equivalences imply many new Wilf-equivalences for vincular patterns
description: 15 pages, 7 figures, 1 table. Presented at Permutation Patterns 2012; Accepted to Advanced in Applied Mathematics
Large-N reduction for N=2 quiver Chern-Simons theories on S^3 and localization in matrix models
Creators: name: Asano, Yuhma
name: Ishiki, Goro
name: Okada, Takashi
name: Shimasaki, Shinji
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study reduced matrix models obtained by the dimensional reduction of N=2 quiver Chern-Simons theories on S^3 to zero dimension and show that if a reduced model is expanded around a particular multiple fuzzy sphere background, it becomes equivalent to the original theory on S^3 in the large-N limit. This is regarded as a novel large-N reduction on a curved space S^3. We perform the localization method to the reduced model and compute the free energy and the vacuum expectation value of a BPS Wilson loop operator. In the large-N limit, we find an exact agreement between these results and those in the original theory on S^3.
description: 46 pages, 11 figures; minor modifications
Nonlinear Schrödinger Equation: Generalized Darboux Transformation and Rogue Wave Solutions
Creators: name: Guo, Boling
name: Ling, Liming
name: Liu, Q. P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: In this paper, we construct a generalized Darboux transformation for nonlinear Schrödinger equation. The associated $N$-fold Darboux transformation is given both in terms of a summation formula and in terms of determinants. As applications, we obtain compact representations for the $N$-th order rogue wave solutions of the focusing nonlinear Schrödinger equation and Hirota equation. In particular, the dynamics of the general third order rogue wave is discussed and shown to exhibit interesting structure.
description: 17 pages, 4 figures, replaced by revised version
title: Johann Justus Faber
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Johann Justus Faber as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
Abelian Gauge Extension of Standard Model: Dark Matter and Radiative Neutrino Mass
Creators: name: Borah, Debasish
name: Adhikari, Rathin
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study a simple extension of Standard Model where the gauge group is extended by an additional $U(1)_X$ gauge symmetry. Neutrino mass arise both at tree level as well as radiatively by the anomaly free addition of one singlet fermion $N_R$ and two triplet fermions $Σ_{1R}, Σ_{2R}$ with suitable Higgs scalars. The spontaneous gauge symmetry breaking is achieved in such a way which results in a residual $Z_2$ symmetry and hence providing a stable cold dark matter candidate. We study the possible dark matter candidates in this model by incorporating the constraints from cosmology as well as direct detection experiments. We discuss both low and high mass (from GeV to the TeV scale) regimes of fermionic and scalar dark matter candidates in the model. We show that scalar dark matter relic density, although not significantly affected by the presence or absence of annihilation into $U(1)_X$ gauge boson pairs, is however affected by choice of $U(1)_X$ gauge charges. We discuss the neutrino mass phenomenology and its compatibility with the allowed dark matter mass ranges and also comment on the implications of the model on Higgs signatures at colliders including those related to fourth fermion generation.
description: 20 pages, 6 figures, figures redrawn and conclusion unchanged, Journal version
Association between essential tremor and blood lead concentration
Creators: name: Louis, Elan D.
name: Jurewicz, Eva C.
name: Applegate, LaKeisha
name: Factor-Litvak, Pam
name: Parides, Michael
name: Andrews, Leslie
name: Slavkovich, Vesna N.
name: Graziano, Joseph
name: Carroll, Spencer
name: Todd, Andrew
Publisher: name: Columbia University
Year: 2003
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Lead is a ubiquitous toxicant that causes tremor and cerebellar damage. Essential tremor (ET) is a highly prevalent neurologic disease associated with cerebellar involvement. Although environmental toxicants may play a role in ET etiology and their identification is a critical step in disease prevention, these toxicants have received little attention. Our objective was to test the hypothesis that ET is associated with lead exposure. Therefore, blood lead (BPb) concentrations were measured and a lifetime occupational history was assessed in ET patients and in controls. We frequency matched 100 ET patients and 143 controls on age, sex, and ethnicity. BPb concentrations were analyzed using graphite furnace atomic absorption spectrophotometry. A lifetime occupational history was reviewed by an industrial hygienist. BPb concentrations were higher in ET patients than in controls (mean ± SD, 3.3 ± 2.4 and 2.6 ± 1.6 µg/dL, respectively; median, 2.7 and 2.3 µg/dL; p = 0.038). In a logistic regression model, BPb concentration was associated with diagnosis [control vs. ET patient, odds ratio (OR) per unit increase = 1.21; 95% confidence interval (CI), 1.05-1.39; p = 0.007]. BPb concentration was associated with diagnosis (OR per unit increase = 1.19; 95% CI, 1.03-1.37; p = 0.02) after adjusting for potential confounders. Prevalence of lifetime occupational lead exposure was similar in ET patients and controls. We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation.
Fertility in essential tremor: data from population-based and clinical sources
Creators: name: Louis, Elan D.
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: The view of essential tremor (ET) as a degenerative disorder, which is now gaining support from postmortem studies, is at odds with traditional views of ET as a 'super-healthy' condition characterized by increased longevity and fertility. Longevity has recently been re-examined in ET, yet fertility, measured by number of offspring, has never been critically assessed in this disease. The objective was to determine whether ET cases and controls differ in terms of number of children. Methods: Family history data were collected on ET cases and controls from 2 distinct sources, a population and a clinical (referred) sample. Results: In the population, the number of children was similar in 59 cases vs. 72 controls [mean ± SD (median) = 2.3 ± 2.9 (1) vs. 2.2 ± 1.8 (2); p = 0.26]. In the referred sample, number of children was similar in 184 cases vs. 241 controls [2.0 ± 1.5 (2) vs. 1.9 ± 1.7 (2); p = 0.33]. In adjusted analyses, results were similar. Conclusions: Fertility, measured by number of children, was similar in cases and controls. With a newer understanding of the biological substrate of ET emerging from postmortem studies, it is important to critically reassess this and other fundamental biological questions about the disease.
BFKL approach and 2->5 MHV amplitude
Creators: name: Bartels, J.
name: Kormilitzin, A.
name: Lipatov, L. N.
name: Prygarin, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study MHV amplitude for the 2 -> 5 scattering in the multi-Regge kinematics. The Mandelstam cut correction to the BDS amplitude is calculated in the leading logarithmic approximation (LLA) and the corresponding remainder function is given to any loop order in a closed integral form. We show that the LLA remainder function at two loops for 2 -> 5 amplitude can be written as a sum of two 2 -> 4 remainder functions due to recursive properties of the leading order impact factors. We also make some generalizations for the MHV amplitudes with more external particles. The results of the present study are in agreement with all leg two loop symbol derived by Caron-Huot as shown in a parallel paper of one of the authors with collaborators.
description: 24 pages, 17 figures
title: Ole Christensen Römer
title: An entry in the LCA Online Dictionary of Leibniz’s Correspondents and Acquaintances
titleType: Subtitle
Creators: name: (:Tba)
Publisher: name: LCA Project
Year: 2018

description: Ole Christensen Römer as a personal relation of Leibniz’s: The resource presents biographical information on a correspondent of Leibniz's
New initial condition of the new agegraphic dark energy model
Creators: name: Li, Yun-He
name: Zhang, Jing-Fei
name: Zhang, Xin
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The initial condition $Ω_{\rm de}(z_{\rm ini})=n^2(1+z_{\rm ini})^{-2}/4$ at $z_{\rm ini}=2000$ widely used to solve the differential equation of the density of the new agegraphic dark energy (NADE) $Ω_{\rm de}$, makes the NADE model be a single-parameter dark-energy cosmological model. However, we find that this initial condition is only applicable in a flat universe with only dark energy and pressureless matter. In fact, in order to obtain more information from current observational data, such as cosmic microwave background (CMB) and baryon acoustic oscillations (BAO), we need to consider the contribution of radiation. For this situation, the initial condition mentioned above becomes invalid. To overcome this shortage, we investigate the evolution of dark energy in the matter-dominated and radiation-dominated epochs, and obtain a new initial condition $Ω_{\rm de}(z_{\rm ini})=\frac{n^2(1+z_{\rm ini})^{-2}}{4}(1+\sqrt{F(z_{\rm ini})})^2$ at $z_{\rm ini}=2000$, where $F(z)\equiv\frac{Ω_{r0}(1+z)}{Ω_{m0}+Ω_{r0}(1+z)}$ with $Ω_{r0}$ and $Ω_{m0}$ being the current density parameters of radiation and pressureless matter, respectively. This revised initial condition is applicable for the differential equation of $Ω_{\rm de}$ obtained in the standard Friedmann-Robertson-Walker (FRW) universe with dark energy, pressureless matter, radiation, and even spatial curvature, and can still keep the NADE model being a single-parameter model. With the revised initial condition and the observational data of type Ia supernova (SNIa), CMB and BAO, we finally constrain the NADE model. The results show that the single free parameter $n$ of the NADE model can be constrained tightly.
description: 6 pages, 1 figure
Nothing about us, without us: Participatory approaches to make data by the people for the people
Creators: name: Greshake Tzovaras, Bastian
Publisher: name: Zenodo
Year: 2023
Subjects: citizen science
transbiome
autspaces
participatory science
participatory research
open source
open science

description: English Abstract Data and AI have by now entered most – if not all – aspects of our lives, from the social over health to the workplace. With this datafication come myriad ethical questions: Which data should (and should not) be collected? What are acceptable uses for those data? And importantly, who gets to decide on these questions? More often than not, these questions are neither posed to nor answered by the people most affected by the data collection and might only be asked once harm has been done. Participatory approaches such as citizen science can be used to give those affected a voice by involving them right from the start and provides a pathway to improving data justice more broadly. This talk will give concrete examples to highlight how participation in fields such as transgender healthcare, Autism research and chronic diseases have been implemented and not only solved some of these issues, but also lead to better and more impactful research as a result. Furthermore, we will give a set of recommendations and ideas on how to start implementing such approaches in your own data practice. En espańol: Nada sobre nosotros, sin nosotros: Enfoques participativos para crear datos por el pueblo y para el pueblo Los datos y la inteligencia artificial se han introducido ya en la mayoría -si no en todos- los aspectos de nuestras vidas, desde el ámbito social hasta el laboral, pasando por la sanidad. Con esta "dataficación" surgen innumerables cuestiones éticas: ¿Qué datos deben (y no deben) recopilarse? ¿Cuáles son los usos aceptables de esos datos? Y, lo que es aún más importante, ¿quién decide sobre estas cuestiones? En la mayoría de los casos, estas preguntas no se plantean a las personas más afectadas por la recopilación de datos ni son respondidas por ellas. Los enfoques participativos, como la ciencia ciudadana, pueden utilizarse para dar voz a los afectados, implicándolos desde el principio, y ofrecen así una vía para mejorar la justicia de los datos en general. En esta charla presentaremos ejemplos concretos que muestran cómo se ha aplicado la participación en campos como la atención sanitaria a transexuales, la investigación sobre el autismo y las enfermedades crónicas, y de esta manera no sólo se han resuelto algunos de estos problemas sino que también se ha conseguido como resultado una investigación mejor y más impactante. Además, daremos una serie de recomendaciones e ideas sobre cómo empezar a aplicar estos enfoques en su propia práctica de datos.
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues
Creators: name: Budhu, Sadna
name: Loike, John D.
name: Pandolfi, Ashley
name: Han, Soo
name: Catalano, Geoffrey
name: Constantinescu, Andrei
name: Clynes, Raphael A.
name: Silverstein, Samuel C.
Publisher: name: Columbia University
Year: 2010
Subjects: Cytology

description: We describe a quantitative model for assessing the cytolytic activity of antigen-specific CD8+ T cells in vitro and in vivo in which the concentration of antigen-specific CD8+ T cells determines the efficiency with which these cells kill cognate antigen-expressing melanoma cells in packed cell pellets, in three-dimensional collagen-fibrin gels in vitro, and in established melanomas in vivo. In combination with a clonogenic assay for melanoma cells, collagen-fibrin gels are 4,500-5,500-fold more sensitive than the packed cell pellet-type assays generally used to measure CD8+ T cell cytolytic activity. An equation previously used to describe neutrophil bactericidal activity in vitro and in vivo also describes antigen-specific CD8+ T cell-mediated cytolysis of cognate antigen-expressing melanoma cells in collagen-fibrin gels in vitro and in transplanted tumors in vivo. We have used this equation to calculate the critical concentration of antigen-specific CD8+ T cells, which is the concentration of these cells required to hold constant the concentration of a growing population of cognate antigen-expressing melanoma cells. It is ~3.5 × 10^5/ml collagen-fibrin gel in vitro and ~3 × 10^6/ml or /g melanoma for previously published studies of ex vivo-activated adoptively transferred tumor antigen-specific CD8+ T cell killing of cognate antigen-expressing melanoma cells in established tumors in vivo. The antigen-specific CD8+ T cell concentration required to kill 100% of 2 × 10^7/ml cognate antigen-expressing melanoma cells in collagen fibrin gels is ≥10^7/ml of gel.
Commuting Pauli Hamiltonians as maps between free modules
Creators: name: Haah, Jeongwan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study unfrustrated spin Hamiltonians that consist of commuting tensor products of Pauli matrices. Assuming translation-invariance, a family of Hamiltonians that belong to the same phase of matter is described by a map between modules over the translation-group algebra, so homological methods are applicable. In any dimension every point-like charge appears as a vertex of a fractal operator, and can be isolated with energy barrier at most logarithmic in the separation distance. For a topologically ordered system in three dimensions, there must exist a point-like nontrivial charge. If the ground-state degeneracy is upper bounded by a constant independent of the system size, then the topological charges in three dimensions always appear at the end points of string operators. A connection between the ground state degeneracy and the number of points on an algebraic set is discussed. Tools to handle local Clifford unitary transformations are given.
description: amsart 48 pages; (v2) minor change, ref. added, (v3) stronger conclusion about topological charges, (v4) comments and ref. added, reproducing the result of 1103.1885