cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantitative analysis of male germline stem cell differentiation reveals a role for the p53-mTORC1 pathway in spermatogonial maintenance
Creators: name: Mulin Xiong
name: Ianina C Ferder
name: Ohguchi, Yasuyo
name: Wang, Ning
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: p53 protects cells from DNA damage by inducing cell-cycle arrest upon encountering genomic stress. Among other pathways, p53 elicits such an effect by inhibiting mammalian target of rapamycin complex 1 (mTORC1), the master regulator of cell proliferation and growth. Although recent studies have indicated roles for both p53 and mTORC1 in stem cell maintenance, it remains unclear whether the p53-mTORC1 pathway is conserved to mediate this process under normal physiological conditions. Spermatogenesis is a classic stem cell-dependent process in which undifferentiated spermatogonia undergo self-renewal and differentiation to maintain the lifelong production of spermatozoa. To better understand this process, we have developed a novel flow cytometry (FACS)-based approach that isolates spermatogonia at consecutive differentiation stages. By using this as a tool, we show that genetic loss of p53 augments mTORC1 activity during early spermatogonial differentiation. Functionally, loss of p53 drives spermatogonia out of the undifferentiated state and causes a consistent expansion of early differentiating spermatogonia until the stage of preleptotene (premeiotic) spermatocyte. The frequency of early meiotic spermatocytes is, however, dramatically decreased. Thus, these data suggest that p53-mTORC1 pathway plays a critical role in maintaining the homeostasis of early spermatogonial differentiation. Moreover, our FACS approach could be a valuable tool in understanding spermatogonial differentiation.
A Comparative Study on Prediction of Evaporation in Arid Area Based on Artificial Intelligence Techniques
Creators: name: Jasmine, Mansura
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Evaporation
Arid area
ANFIS
Artificial Intelligence
Statistical Analysis

description: Estimation of evaporation from open water is essential for hydrodynamics, manufacturing industries, irrigation, farming, environmental protection and many other purposes. It is also important for proper management of hydrological resources such as reservoirs, lakes and rivers. Recent methods are mostly data-driven methods, such as using Artificial Intelligence techniques. Adaptive Neuro Fuzzy Inference System (ANFIS) is one of them and has been widely adopted in many hydrological fields for its simplicity. The current research presents a comparative study on the impact of optimization techniques such as Firefly Algorithm (FFA), Genetic Algorithm (GA), Particle Swarm Optimizer (PSO) and Ant Colony Optimization (ACO) on obtained results. In addition, a practical method named Multi Gene-genetic Programming (MGGP) is employed to propose an equation for the estimation of the Evaporation. Six different measured weather variables are taken, which are maximum, minimum and average air temperature, sunshine hours, wind speed and relative humidity. Models are separately calibrated with total data set collected over an eight-year period of 2010-2017 at the specified station “Arizona” in the United States of America. Ten statistical indices are calculated to verify the results. All optimizers were observed and compared to check if the results are better than ANFIS or not. The objectives of the adoption of different optimizer techniques was to verify the accuracy of the prediction by ANFIS model. Comparisons showed that ANFIS and MGGP are slightly better than the other models. MGGP model is different from other models in a way that it provides a set of equations instead of showing numerical values; therefore, the computational time is high. PSO, FFA, ACO and GA are considered as optimizers in the main model. Though PSO provided very similar results to the ANFIS model and MGGP gives even better results than basic ANFIS model. ANFIS is easier in terms of model formation. ANFIS is simpler to build and easy to operate. Since the prediction was quite identical in all cases, the ANFIS model was suggested due to its simplicity.
Nano-Fe3O4@silica sulfuric acid as a reusable and magnetically separable potent solid acid catalyst in Biginelli-type reaction for the one-pot multicomponent synthesis of fused dihydropyrimidine derivatives: A greener NOSE and SFRC approach
Creators: name: Binoyargha Dam
name: Amarta Kumar Pal
name: Gupta, Ajay
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: An efficient, highly product selective, eco-friendly, one-pot multicomponent synthesis of dihydropyrimidine derivatives via Biginelli reaction has been described. The reaction was developed by greener nanoparticle-catalyzed organic synthesis enhancement (NOSE) chemistry and solvent free reaction condition (SFRC) approaches, which helped us in making the procedure greener. The reaction went smoothly with a diverse range of aromatic, aliphatic, hetero-aromatic aldehydes, different amine sources, as well as various β-dicarbonyl compounds, showing the flexibility of this methodology. Magnetically separable nano-Fe3O4@SiO2@SO3H, which acts as a potent solid acid catalyst, was characterized by FT-IR, SEM, EDX and TEM, VSM, and TGA analyses. The catalyst was recycled from the reaction mixture easily by an external magnet and reused in five more consecutive runs without much decrease in catalytic activity. Its catalytic efficiency was compared to other nano and bulk solid acid catalyst in order to ascertain the best combination for the conversion.
Developments in thermophotovoltaics (TPV)
Creators: name: Esther López
name: Alejandro Datas
Publisher: name: Zenodo
Year: 2024

description: Thermophotovoltaic (TPV) cells are solid-state devices capable of converting the heat radiated by incandescent bodies (named emitters) into electricity using low bandgap semiconductor materials. The characteristics of this technology are very appealing in different applications, such as waste heat recovery, energy storage and portable generators, where high conversion efficiencies can be achieved due to the fact that the emitter and the cells can see each other with high view factors, so it is possible to reflect back to the emitter the low energy photons that do not contribute to photogeneration in the cell. Then, the energy associated to those photons is not considered an energy loss since it can be recycled in the heat source. This recycling process establishes a net radiative heat flux from the emitter to the cells that need to be quantified to determine the TPV conversion efficiency. An overview on the characterization of this efficiency will be presented, together with the record values obtained and the future prospects in the TPV field.
Quantitative analysis of male germline stem cell differentiation reveals a role for the p53-mTORC1 pathway in spermatogonial maintenance
Creators: name: Wang, Ning
name: Mulin Xiong
name: Ianina C Ferder
name: Ohguchi, Yasuyo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Physiology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: p53 protects cells from DNA damage by inducing cell-cycle arrest upon encountering genomic stress. Among other pathways, p53 elicits such an effect by inhibiting mammalian target of rapamycin complex 1 (mTORC1), the master regulator of cell proliferation and growth. Although recent studies have indicated roles for both p53 and mTORC1 in stem cell maintenance, it remains unclear whether the p53-mTORC1 pathway is conserved to mediate this process under normal physiological conditions. Spermatogenesis is a classic stem cell-dependent process in which undifferentiated spermatogonia undergo self-renewal and differentiation to maintain the lifelong production of spermatozoa. To better understand this process, we have developed a novel flow cytometry (FACS)-based approach that isolates spermatogonia at consecutive differentiation stages. By using this as a tool, we show that genetic loss of p53 augments mTORC1 activity during early spermatogonial differentiation. Functionally, loss of p53 drives spermatogonia out of the undifferentiated state and causes a consistent expansion of early differentiating spermatogonia until the stage of preleptotene (premeiotic) spermatocyte. The frequency of early meiotic spermatocytes is, however, dramatically decreased. Thus, these data suggest that p53-mTORC1 pathway plays a critical role in maintaining the homeostasis of early spermatogonial differentiation. Moreover, our FACS approach could be a valuable tool in understanding spermatogonial differentiation.
La dirección de Literatura de la UNAM y la Cátedra Julio Cortázar de la Universidad de Guadalajara invitan a la presentación de los primeros títulos de la Biblioteca Cortázar
Creators: name: UNAM
name: Universidad De Guadalajara
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Biblioteca Cortázar

description: Invitación a la presentación de los primeros títulos de la Biblioteca Cortázar por la dirección de Literatura de la UNAM (Universidad Nacional Autónoma de México) y la Cátedra Julio Cortázar de la Universidad de Guadalajara. Primeros títulos presentados: "Imagen de Julio Cortázar" por Ignacio Solares, "Otra flor amarilla – Homenaje a Julio Cortázar" (Antología), "El alacrán atrapado – Una poética de la destrucción en Julio Cortázar", por Davi Arrigucci Jr., y "Julio Cortázar desde tres perspectivas" por Luisa Valenzuela, Bella Josef y Alain Sicard.
description: Notas: Serie de cuatro tarjetas de invitación, cada una con una portada de los primeros títulos presentados de la Biblioteca Cortázar.
description: Source: Num.Ref. : JC-DY-CAR-04.065
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Simple and efficient access to pyrazine-2,5- and -2,6-dicarbaldehydes
Creators: name: Coufal, Radek
name: Prusková, Markéta
name: Císařová, Ivana
name: Dušan Drahoňovský
name: Jiří Vohlídal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Efficient two-step synthesis of pyrazine-2,5- and -2,6-dicarbaldehydes is presented that consists of transformation of easily available corresponding dimethylpyrazines to distyryl derivatives and oxidation of the latter with the tandem system of osmium tetroxide/periodate ions. The proper choice of dehydration agent in the first reaction step and the good efficiency of the subsequent low-temperature oxidation are the key points of the developed protocol. Other examined synthesis routes were much less successful, but one of them leads to new powerful routes to methyl (5-hydroxymethyl)pyrazine-2-carboxylate and dimethyl 3,4-dihydropyrazine-2,6-dicarboxylate. Previously unknown characteristics of the title compounds are reported.
Nano-Fe3O4@silica Sulfuric Acid as a Reusable and Magnetically Separable Potent Solid Acid Catalyst in Biginelli-Type Reaction for the One-Pot Multicomponent Synthesis of Fused Dihydropyrimidine Derivatives: A Greener NOSE and SFRC Approach
Creators: name: Binoyargha Dam
name: Amarta Kumar Pal
name: Gupta, Ajay
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biochemistry

description: An efficient, highly product selective, eco-friendly, one-pot multicomponent synthesis of dihydropyrimidine derivatives via Biginelli reaction has been described. The reaction was developed by greener “NOSE” (nanoparticle catalysed organic synthesis enhancement chemistry) and “SFRC” (Solvent free reaction condition) approaches which helped us in making the procedure greener. The said reaction went smoothly with a diverse range of aromatic, aliphatic, hetero-aromatic aldehydes, different amine sources as well as various β-dicarbonyl compounds, showing the flexibility of this methodology. Magnetically separable nano-Fe3O4@SiO2@SO3H, which acts as a potent solid acid catalyst was characterized by FT-IR, SEM, EDX and TEM, VSM and TGA analyses. Catalyst was recycled from the reaction mixture easily by external magnet and reused in five more consecutive runs without much decrease in catalytic activity. It’s catalytic efficiency was compared to other nano and bulk solid acid catalyst in order to ascertain it best for the said conversion.
Simple and Effcient Access to Pyrazine-2,5- and -2,6-dicarbaldehydes
Creators: name: Císařová, Ivana
name: Coufal, Radek
name: Prusková, Markéta
name: Dušan Drahoňovský
name: Jiří Vohlídal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Microbiology
subject: Biochemistry

description: Efficient two-step synthesis of pyrazine-2,5- and -2,6-dicarbaldehydes is presented that consists of transformation of easy available corresponding dimethylpyrazines to distyryl derivatives and oxidation of the latters with the tandem system osmium tetroxide/periodate ions. The proper choice of dehydration agent in the first reaction step and the high efficiency of the subsequent low-temperature oxidation are the key points of the developed protocol. Other examined synthesis routes were much less successful, but one of them lead to new powerful routes to methyl (5-hydroxymethyl)pyrazine-2-carboxylate and dimethyl 3,4-dihydropyrazine-2,6-dicarboxylate. So far unknown characteristics of the title compounds are reported.
From the research on socially-sustainable agriculture (44). Food security and agro-biodiversity
Creators: name: Kruk, Hanna
name: Krzyżanowski, Julian Tadeusz
name: Kwasek, Mariola
name: Obiedzińska, Agnieszka
name: Kwasek, Mariola (Ed.)
name: Kruk, Hanna
name: Krzyżanowski, Julian Tadeusz
name: Kwasek, Mariola
name: Obiedzińska, Agnieszka
name: Kwasek, Mariola (Ed.)
Publisher: name: Unknown
Year: 2017
Subjects: subject: Environmental Economics and Policy
subject: agriculture
subject: agro-biodiversity
subject: biodiversity
subject: fishery
subject: food security
subject: socially-sustainable agriculture

description: The aim of the work is to determine the role of biodiversity in agriculture and fishery in contributing to ensure food security. Chapters: Food security and biodiversity conservation key challenges of the 21st century. Factors influencing the loss of biodiversity. Methods of assessing agro-biodiversity. Tools to support the protection of biodiversity in the agricultural space.
Versatile and mild HCl-catalyzed cationic imino Diels-Alder reaction for the synthesis of new tetrahydroquinoline derivatives
Creators: name: Bohórquez, Arnold R. Romero
name: Romero-Daza, Jorge
name: Acelas, Mauricio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A simple, inexpensive, and mild one-pot methodology for the synthesis of novel 4-aryl-3-methyl-1,2,3,4-tetrahydroquinolines derivatives using aqueous HCl as catalyst has been developed. The key step involves the formal inverse-electron-demand [4π+ + 2π] cycloaddition reaction of in situ–generated cationic 2-azadienes with arylpropenes (isoeugenol and trans-anethole). Iminium ion intermediates are generated through the condensation between N-benzylanilines and formalin. The products are obtained with good to excellent yields and high trans-diastereoselectivity. Further catalytic hydrogenation (Pd/C) allowed debenzylation to successfully obtain the respective 4-aryl-3-methyl-N-H-tetrahydroquinolines of interest. Recent reports suggest that these compounds could serve as interesting models in pharmacological studies against parasites that cause the most common tropical diseases.
Total synthesis of lasofoxifene and nafoxidine
Creators: name: Pailla Umareddy
name: Arava, Veera Reddy
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: An intramolecular reductive coupling process of diketone with low-valent titanium species to form a dihydronapthalene skeleton was an important step in the synthesis of nafoxidine (1) and lasofoxifene (2). Diketone 6 was prepared in a convenient, three-step sequence starting from 3-methoxy benzaldehyde in good yields.
Stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A
Creators: name: Gattu Sridhar
name: Gangavaram V. M. Sharma
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: A simple and efficient stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A, from epichlorohydrin, using asymmetric synthetic approach is reported. The key reactions involved are Sharpless epoxidation, Jacobsen reaction, syn-allylation, Yamaguchi esterification, and Grubbs ring-closing metatheses reaction to result in the macrocyclic ring system.
Total Synthesis of Lasofoxifene and Nafoxidine
Creators: name: Pailla Umareddy
name: Reddy, Veera Arava
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Cell Biology
subject: Biochemistry

description: An intra molecular reductive coupling process of diketone with low-valent titanium species to form dihydronapthalene skeleton was an important step in the synthesis of Nafoxidine (1) and Lasofoxifene (2). Diketone 6 was prepared in a convenient three step sequence starting from 3-methoxy benzaldehyde in good yields.
Consumer Milk Expenditures and Preferences for Tennessee Milk
Creators: name: Upendram, Sreedhar
name: Jensen, Kimberly L.
name: DeLong, Karen
name: Menard, Jamey
name: Eckelkamp, Elizabeth
name: Upendram, Sreedhar
name: Jensen, Kimberly L.
name: DeLong, Karen
name: Menard, Jamey
name: Eckelkamp, Elizabeth
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agribusiness
subject: Community/Rural/Urban Development
subject: Demand and Price Analysis
subject: Food Consumption/Nutrition/Food Safety
subject: consumer
subject: milk
subject: expenditures
subject: preferences
subject: Tennessee
subject: dairy
subject: operations

description: The dairy industry in Tennessee has experienced changes over the past few decades. As of August 2019, the current number of dairy operations licensed to sell Grade A milk in the state is 196, down from 271 in 2018 (Tennessee Department of Agriculture). A potential market opportunity for Tennessee dairy producers is to sell milk to consumers who prefer local milk. In 2018, the Tennessee Department of Agriculture, Business Development Division, instituted the Tennessee Milk logo. This logo was designed to help consumers identify milk that was entirely sourced, processed and bottled in Tennessee. The market for milk with the Tennessee Milk logo is emerging and little is known about consumers’ preferences and attitudes toward fluid milk labeled with the Tennessee Milk logo. The goal of this publication is to convey results of a consumer survey regarding Tennessee consumers’ milk expenditures and preferences for Tennessee Milk to dairy producers, retailers and policy makers. This study presents: • Willingness to pay for Tennessee Milk. • Purchase amounts for Tennessee Milk. • Locations where consumers would purchase Tennessee Milk. • Consumer attitudes toward Tennessee Milk. • Distance traveled for milk to be considered local. • Current milk purchase patterns. • Respondent demographics.
title: Analysis of brain structure in premature-born adults
Creators: name: Makarov, Christine
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2021

description: My master’s thesis with the title “Analysis of brain structure in premature-born adults” is based on the discoveries of various developmental differences that have been found in premature-born individuals, both shortly after birth and in adults. However, it was not known to what extent these developmental differences are correlated and whether there might even be a causal relationship between structural differences and cognitive performance. To investigate these questions, MRI derived information on brain structure is combined in order to compute dependencies between different affected developmental processes. The analyses include statistical testing, correlation analysis as well as causal inference on a dataset consisting of 101 very preterm-born/ very low birth weight adults and 111 term-born control subjects. We found significant differences in very preterm- compared to term-born adults in multiple developmental processes, and these processes can be grouped by similarity into four main clusters. Furthermore, we found causal relationships between several developmental processes and cognitive performance. These findings pave the way for further research with the goal to improve risk prediction and the development of drug targets for preterm-born neonates.
Stereoselective Total Synthesis of Sporiolide B and Attempted Synthesis of Sporiolide A
Creators: name: Gattu Sridhar
name: Gangavaram V. M. Sharma
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: A simple and efficient stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A, from epichlorohydrin is reported by asymmetric synthetic approach. The key reactions involved are Sharpless epoxidation, Jacobsen reaction, syn-allylation, Yamaguchi esterification and Grubbs RCM reaction to result in the macrocyclic ring system.
PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures
Creators: name: Johansson, Torsten
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Hematology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine

description: Background and purpose — There is solid evidence from animal experiments that parathyroid hormone (PTH) improves fracture healing. So far, only 3 papers on PTH and fracture repair in humans have been published. They suggest that PTH may enhance fracture healing, but the results do not appear to justify specific clinical recommendations. This study was carried out to determine whether teriparatide enhances fracture healing of proximal humerus fractures.Patients and methods — 40 post-menopausal women with a proximal humerus fracture were randomized to either daily injections with 20 µg teriparatide (PTH 1-34 (Forteo)) for 4 weeks or control treatment. At randomization, the patients were asked to assess how their pain at rest and during activity (visual analog scale (VAS)) and also function (DASH score) had been prior to the fracture. At 7 weeks and again at 3 months, their current state was assessed and the tests were repeated, including radiographs. 2 radiologists performed a blind qualitative scoring of the callus at 7 weeks. Callus formation was arbitrarily classified as ”normal” or “better”.Results — 39 patients completed the follow-up. The radiographic assessment showed a correct correlation, “better” in the teriparatide group and “normal” in the control group, in 21 of the 39 cases. There were no statistically significant differences in pain, in use of strong analgesics, or in function between the groups at the follow-up examinations.Interpretation — There were no radiographic signs of enhanced healing or improved clinical results in the group treated with teriparatide
Versatile and Mild HCl-Catalyzed Cationic Imino Diels-Alder Reaction for the Synthesis of New Tetrahydroquinoline Derivatives
Creators: name: Bohórquez, Arnold R. Romero
name: Romero-Daza, Jorge
name: Acelas, Mauricio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biological Sciences
Chemistry
Biotechnology
Pharmacology
Biochemistry

description: A simple, inexpensive and mild one-pot methodology for the synthesis of novel 4-aryl-3-methyl-1,2,3,4-tetrahydroquinolines derivatives using aqueous HCl as catalyst has been developed. The key step involves the formal inverse-electron-demand [4π+ + 2π] cycloaddition reaction of in situ-generated cationic 2-azadienes with arylpropenes (isoeugenol and trans-anethole). Iminium ion intermediates are generated through the condensation between N-benzylanilines and formalin. The products are obtained with good to excellent yields and high trans-diastereoselectivity. Further catalytic hydrogenation (Pd/C) allowed debenzylation to successfully obtain the respective 4-aryl-3-methyl-N-H-tetrahydroquinolines of interest. Recent reports suggest that these compounds could serve as interesting models in pharmacological studies against parasites that cause the most common tropical diseases.
Computational fluid dynamics investigation of bitumen residues in oil sands tailings transport in an industrial horizontal pipe
Creators: Sontti, Somasekhara Goud
Sadeghi, Mohsen
Khou, Kaiyu
Zheng, Enzu
Zhang, Xuehua
Publisher: name: University of Alberta Library
Year: 2023

Pipeline transport is commonly used in the oil sand industry to convey crushed oil sand ores and tailings. Bitumen residues in the oil sand tailings can be a threat to the environment that separating them from tailings before disposal is crucial. However, low bitumen concentration in the tailing slurry and the complex transport characteristics of the four-phase mixture make the process difficult. This study establishes an Eulerian–Eulerian (E–E) computational fluid dynamics model for an industrial-scale oil sand tailings pipeline. A comprehensive sensitivity analysis was conducted on the selection of carrier-solid and solid-bitumen drag models. The combination of small and large particle sizes (i.e., 75 and 700 μm) and bitumen droplet size (i.e., 400 μm) provided good agreement with field data in velocity profiles and pressure drop. The validated model was subsequently extended to investigate the influence of the secondary phase (i.e., bitumen droplets and bubbles) on flow characteristics in a tailing pipeline. The investigation covered a range of bitumen droplet size (100–400 μm), bitumen fraction (0.0025–0.1), bubble size (5–1000 μm), and bubble fraction (0.0025–0.3) and their influences on the velocity, solids, and bitumen distribution are revealed. For an optimum bubble size of 500 μm, a maximum recovery of 59% from the top 50% and 83% from the top 75% of the pipe cross section was obtained. The present study demonstrates the preferential distribution of bitumen and provides valuable insight into bitumen recovery from an industrial-scale tailing pipeline.
The role of “cell therapy” in osteonecrosis of the femoral head
Creators: name: Jones, Elena
name: Papakostidis, Costas
name: Tosounidis, Theodoros H
name: Giannoudis, Peter V
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Hematology
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences

description: Background and purpose — The value of core decrompression for treatment of osteonecrosis of the femoral head (ONFH) is unclear. We investigated by a literature review whether implantation of autologous bone marrow aspirate, containing high concentrations of pluripotent mesenchymal stem cells, into the core decompression track would improve the clinical and radiological results compared with the classical method of core decompression alone. The primary outcomes of interest were structural failure (collapse) of the femoral head and conversion to total hip replacement (THR).Patients and methods — All randomized and non-randomized control trials comparing simple core decompression with autologous bone marrow cell implantation into the femoral head for the treatment of ONFH were considered eligible for inclusion. The methodological quality of the studies included was assessed independently by 2 reviewers using the Cochrane Collaboration tool for assessing risk of bias in randomized studies. Of 496 relevant citations identified, 7 studies formed the basis of this review.Results — The pooled estimate of effect size for structural failure of the femoral head favored the cell therapy group, as, in this treatment group, the odds of progression of the femoral head to the collapse stage were reduced by a factor of 5 compared to the CD group (odds ratio (OR) = 0.2, 95% CI: 0.08–0.6; p = 0.02). The respective summarized estimate of effect size yielded halved odds for conversion to THR in the cell therapy group compared to CD group (OR = 0.6, 95% CI: 0.3–1.02; p = 0.06).Interpretation — Our findings suggest that implantation of autologous mesenchymal stem cells (MSCs) into the core decompression track, particularly when employed at early (pre-collapse) stages of ONFH, would improve the survivorship of femoral heads and reduce the need for hip arthroplasty.
Data from: Dominance reversals and the maintenance of genetic variation
Creators: name: Grieshop, Karl
Publisher: name: Zenodo
Year: 2024
Subjects: Balancing selection
dominance reversal
dominance modifier
Genetic conflict
genetic trade-offs
genetic variation

description: Beneficial reversals of dominance reduce the costs of genetic trade-offs and can enable selection to maintain genetic variation for fitness. Beneficial dominance reversals are characterized by the beneficial allele for a given context (e.g. habitat, developmental stage, trait, or sex) being dominant in that context but recessive where deleterious. This context-dependence at least partially mitigates the fitness consequence of heterozygotes carrying one non-beneficial allele for their context and can result in balancing selection that maintains alternative alleles. Dominance reversals are theoretically plausible and are supported by mounting empirical evidence. Here we highlight the importance of beneficial dominance reversals as a mechanism for the mitigation of genetic conflict and review the theory and empirical evidence for them. We identify some areas in need of further research and development and outline three methods (dominance ordination, allele-specific expression, and allele-specific ATAC-Seq) that could facilitate the identification of antagonistic genetic variation. There is ample scope for the development of new empirical methods as well as reanalysis of existing data through the lens of dominance reversals. A greater focus on this topic will expand our understanding of the mechanisms that resolve genetic conflict and whether they maintain genetic variation.
description: Funding provided by: Swedish Research CouncilCrossref Funder Registry ID: https://ror.org/03zttf063Award Number: 2018-06775
Funding provided by: Natural Sciences and Engineering Research CouncilCrossref Funder Registry ID: https://ror.org/01h531d29Award Number:
Funding provided by: University of TorontoCrossref Funder Registry ID: https://ror.org/03dbr7087Award Number:
description: This is the python code and supporting files for a custom forward-time population genetic simulation of a biophysically explicit gene network subject to sexually antagonistic selection.
Practical limitations of aerosol separation by a tandem differential mobility analyzer–aerosol particle mass analyzer
Creators: name: Radney, James G.
name: Zangmeister, Christopher D.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A cavity ring-down spectrometer and condensation particle counter were used to investigate the limitations in the separation of singly and multiply charged aerosol particles by a tandem differential mobility analyzer (DMA) and aerosol particle mass analyzer (APM). The impact of particle polydispersity and morphology was investigated using three materials: nearly monodisperse polystyrene latex nanospheres (PSL); polydisperse, nearly spherical ammonium sulfate (AS), and polydisperse lacey fractal soot agglomerates. PSL and AS particles were easily resolved as a function of charge. For soot, the presence of multiply charged particles severely affects the isolation of the singly charged particles. In cases where the DMA–APM was unable to fully resolve the singly charged particles of interest, the peak mass deviated by up to 13% leading to errors in the mass specific extinction cross section of over 100%. For measurements of nonspherical particles, nonsymmetrical distributions of concentration as a function of mass were a sign of the presence of multiply charged particles. Under these conditions, the effects of multiply charged particles can be reduced by using a second charge neutralizer after the DMA and prior to the APM. Dilution of the aerosol stream serves to decrease the total number concentration of particles and does not remove the contributions of multiply charged particles.
Generating a geospatial database of U.S. regional feedstock production for use in evaluating the environmental footprint of biofuels
Creators: name: Holder, Christopher T.
name: Cleland, Joshua C.
name: LeDuc, Stephen D.
name: Zac Andereck
name: Hogan, Chris
name: Martin, Kristen M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Computational Biology

description: The potential environmental effects of increased U.S. biofuel production often vary depending upon the location and type of land used to produce biofuel feedstocks. However, complete, annual data are generally lacking regarding feedstock production by specific location. Corn is the dominant biofuel feedstock in the U.S., so here we present methods for estimating where bioethanol corn feedstock is grown annually and how much is used by U.S. ethanol biorefineries. We use geospatial software and publicly available data to map locations of biorefineries, estimate their corn feedstock requirements, and estimate the feedstock production locations and quantities. We combined these data and estimates into a Bioethanol Feedstock Geospatial Database (BFGD) for years 2005–2010. We evaluated the performance of the methods by assessing how well the feedstock geospatial model matched our estimates of locally-sourced feedstock demand. On average, the model met approximately 89 percent of the total estimated local feedstock demand across the studied years—within approximately 25-to-40 kilometers of the biorefinery in the majority of cases. We anticipate that these methods could be used for other years and feedstocks, and can be subsequently applied to estimate the environmental footprint of feedstock production. Implications: Methods used to develop the Bioethanol Feedstock Geospatial Database (BFGD) provide a means of estimating the amount and location of U.S. corn harvested for use as U.S. bioethanol feedstock. Such estimates of geospatial feedstock production may be used to evaluate environmental impacts of bioethanol production and to identify conservation priorities. The BFGD is available for 2005–2010, and the methods may be applied to additional years, locations, and potentially other biofuels and feedstocks.
Cognitive impairment in ALS patients and validation of the Spanish version of the ALS-CBS test
Creators: name: Turon-Sans, Janina
name: Gascon-Bayarri, Jordi
name: Reñé, Ramon
name: Rico, Imma
name: Gámez, Cristina
name: Paipa, Andres
name: Povedano, Monica
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: Our aim was to develop and validate the Spanish version of the Amyotrophic Lateral Sclerosis Cognitive Behavioural Screen (ALS-CBS) and investigate behavioural/cognitive impairment in our ALS patients. We enrolled 50 patients with definite or probable ALS, evaluated by the Motor Neuron Disease Unit (using El Escorial criteria) and Dementia Unit, and assessed with the Spanish ALS-CBS. The patients’ cognitive/behavioural status was classified according to current criteria. Patients were classified into each diagnostic category: ALS-no impairment, 36%; ALS-mild cognitive impairment, 34%; ALS-mild behavioural impairment, 6%; ALS-mild cognitive/behavioural impairment, 12%; ALS-frontotemporal dementia, 12%. Cognitive impairment was more common in bulbar (90.9%) than spinal (48.7%) forms (p The Spanish ALS-CBS was validated. Performance to differentiate normal vs. impaired individuals was: 1) cognition (cut-off 15; AUC, 84.7%): sensitivity 86.2%, specificity 62%, positive predictive value 75.8%, negative predictive value 76.5%; 2) behaviour (cut-off 36; AUC, 83.3%): sensitivity 93.3%, specificity 74.3%, positive predictive value 61%, negative predictive value 96.3%. Performance to differentiate between patients with and without dementia: 1) cognition (cut-off 8; AUC, 87.3%): sensitivity 83.3%, specificity 75%, positive predictive value 31.3%, negative predictive value 97.1%; 2) behaviour (cut-off 35; AUC, 80.9%): sensitivity 83.3%, specificity 69%, positive predictive value 25%, negative predictive value 96.7%. In conclusion, cognitive impairment is common in ALS patients, particularly in bulbar forms. The Spanish version of the ALS-CBS is useful for screening cognitive/behavioural impairment in this population.
U.S. Shoppers’ Access to Multiple Food Stores Varies by Region
Creators: name: Rhone, Alana
name: Ver Ploeg, Michele
name: Rhone, Alana
name: Ver Ploeg, Michele
Publisher: name: Unknown
Year: 2019
Subjects: subject: Consumer/Household Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: food choice
subject: American Community Survey (ACS)
subject: supermarket
subject: supercenter
subject: large grocery store

description: ERS researchers recently calculated distances between households and the nearest and third-nearest food stores. Distance to the third-nearest store gives a sense of consumer choice and the competition facing the nearest store. The median distance to the third-nearest food store for the overall U.S. population was 1.7 miles in 2015; for rural residents, this distance was 6.1 miles.
title: Хранилища данных
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебное пособие является кратким введением в технологию хранилищ данных и содержит необходимый материал по разработке хранилищ данных. Издание включает в себя 18 глав, в которых представлены следующие темы для изучения: определение хранилища данных, основные моменты жизненного цикла, как можно посмотреть на структуру проекта создания хранилища данных, описание многомерной модели, сложившиеся подходы к многомерному проектированию (корпоративное хранилище данных, связанные киоски данных, Data Vault, обзор Anchor-модели), обзор SQL для агрегации и аналитики, вопросы проектирования производительности, основы оптимизации запросов, представление о метаданных и базовые схемы процессов извлечения, преобразования и загрузки данных. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, обучающихся по направлениям подготовки 09.03.03 «Прикладная информатика», 38.03.05 «Бизнес-информатика», 38.04.04 «Государственное и муниципальное управление», изучающих дисциплину «Хранилища данных», Может быть использовано в преподавании иных дисциплин, предусматривающих изучение технологии хранилищ данных. Будет полезно широкому кругу работников IT-сферы.
FORMING A COMMUNICATIVE-PRAGMATIC DIRECTION
Creators: name: Hilola Zaynieva Associate Professor, Tashkent State Pedagogical University,  Republic of Uzbekistan
Publisher: name: Zenodo
Year: 2024

description: This article is devoted to summarizing the achievements of pragmalinguistics, which is a relatively new branch of linguistics, and to the scientific analysis of theoretical views about its prospects. The article examines the initial experiments, which gathered a wide range of scientific materials on the essence and practical importance of ethnopragmatics, sociopragmatics, comparative pragmatics and other scientific directions, which are the "descendants" of pragmalinguistics.

Keywords

Linguistics, pragmatics, ethnopragmatics, sociopragmatics, pragmalinguistics, concept, phenomena, psychosystematic, speech phenomena, diachrony, internal, linguistic, voluntary, conditional.
title: Auswirkungen von Open Access auf wissenschaftlichen Impact: Ergebnisse des OASE-Projekts
Creators: name: Zervos, Sophie
Publisher: name: GESIS - Leibniz Institute for the Social Sciences
publisherIdentifier: https://ror.org/018afyw53
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Preprints
subject: Open Access
subject: Open Data
subject: Visibility
subject: Impact

description: The research project "OASE – Open-Access Effects" studied the impact of Open Access on scientific influence across disciplines. It found that Open Access, especially preprints, boosts visibility, but publishing behavior remains largely shaped by disciplinary norms.
description: Das Forschungsprojekt „OASE – Open-Access-Effekte“ untersuchte die Auswirkungen von Open Access auf den wissenschaftlichen Impact in verschiedenen Disziplinen. Es zeigte, dass Open Access, insbesondere Preprints, die Sichtbarkeit erhöht, das Publikationsverhalten jedoch stark von disziplinären Normen geprägt bleibt.
description: GESIS Blog
Cognitive impairment in ALS patients and validation of the Spanish version of the ALS-CBS test
Creators: name: Turon-Sans, Janina
name: Gascon-Bayarri, Jordi
name: Reñé, Ramon
name: Rico, Imma
name: Gámez, Cristina
name: Paipa, Andres
name: Povedano, Monica
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: Our aim was to develop and validate the Spanish version of the Amyotrophic Lateral Sclerosis Cognitive Behavioural Screen (ALS-CBS) and investigate behavioural/cognitive impairment in our ALS patients. We enrolled 50 patients with definite or probable ALS, evaluated by the Motor Neuron Disease Unit (using El Escorial criteria) and Dementia Unit, and assessed with the Spanish ALS-CBS. The patients’ cognitive/behavioural status was classified according to current criteria. Patients were classified into each diagnostic category: ALS-no impairment, 36%; ALS-mild cognitive impairment, 34%; ALS-mild behavioural impairment, 6%; ALS-mild cognitive/behavioural impairment, 12%; ALS-frontotemporal dementia, 12%. Cognitive impairment was more common in bulbar (90.9%) than spinal (48.7%) forms (p The Spanish ALS-CBS was validated. Performance to differentiate normal vs. impaired individuals was: 1) cognition (cut-off 15; AUC, 84.7%): sensitivity 86.2%, specificity 62%, positive predictive value 75.8%, negative predictive value 76.5%; 2) behaviour (cut-off 36; AUC, 83.3%): sensitivity 93.3%, specificity 74.3%, positive predictive value 61%, negative predictive value 96.3%. Performance to differentiate between patients with and without dementia: 1) cognition (cut-off 8; AUC, 87.3%): sensitivity 83.3%, specificity 75%, positive predictive value 31.3%, negative predictive value 97.1%; 2) behaviour (cut-off 35; AUC, 80.9%): sensitivity 83.3%, specificity 69%, positive predictive value 25%, negative predictive value 96.7%. In conclusion, cognitive impairment is common in ALS patients, particularly in bulbar forms. The Spanish version of the ALS-CBS is useful for screening cognitive/behavioural impairment in this population.