Distinct Characteristics of Asthma Overlap Phenotypes: Insights from the Turkish Adult Asthma Registry
Creators: name: Ozdemir, Secil Kepil
name: Gemicioglu, Bilun
name: Yildiz, Fusun
name: Hayme, Serhat
name: Alpagat, Gulistan
name: Bozkurt, Nurgul
name: Bulut, Ismet
name: Erdinc, Munevver
name: Karakaya, Gul
name: Keren, Metin
name: Cetin, Gulden Pacaci
name: Yilmaz, Insu
name: Yorgancioglu, Arzu
name: Aydin, Omur
name: Gokmen, Derya
name: Buhari, Gozde Koycu
name: Sozener, Zeynep Celebi
name: Beyaz, Sengul
name: Orcen, Cihan
name: Damadoglu, Ebru
name: Yakut, Tugce
name: Kalpaklioglu, Ayse Fusun
name: Baccioglu, Ayse
name: Yalim, Sumeyra Alan
name: Kalkan, Ilkay Koca
name: Uysal, Mehmet Atilla
name: Niksarlioglu, Elif Yelda Ozgun
name: Kalyoncu, Ali Fuat
name: Erbay, Muge
name: Nayci, Sibel
name: Tepetam, Fatma Merve
name: Akkor, Asli
name: Dirol, Hulya
name: Goksel, Ozlem
name: Karaoglanoglu, Selen
name: Erkekol, Ferda Oner
name: Isik, Sacide Rana
name: Yavuz, Yasemin
name: Karadogan, Dilek
name: Seker, Ummuhan
name: Oguzulgen, Ipek Kivilcim
name: Basyigit, Ilknur
name: Baris, Serap Argun
name: Ucar, Elif Yilmazel
name: Erdogan, Tuba
name: Polatli, Mehmet
name: Ediger, Dane
name: Gunaydin, Fatma Esra
name: Turk, Murat
name: Pur, Leyla
name: Katran, Zeynep Yegin
name: Sekibag, Yonca
name: Aykac, Enes Furkan
name: Mungan, Dilsad
name: Gul, Ozcan
name: Cengiz, Ali
name: Akkurt, Bulent
name: Ozden, Seyma
name: Demir, Semra
name: Unal, Derya
name: Aslan, Ayse Feyza
name: Can, Ali
name: Gumusburun, Reyhan
name: Bogatekin, Gulhan
name: Akten, Hatice Serpil
name: Inan, Sinem
name: Ogus, Aliye Candan
name: Kavas, Murat
name: Yulug, Demet Polat
name: Cakmak, Mehmet Erdem
name: Kaya, Saltuk Bugra
name: Ozgur, Eylem Sercan
name: Uzun, Oguz
name: Gulen, Sule Tas
name: Pekbak, Gulseren
name: Kizilirmak, Deniz
name: Havlucu, Yavuz
name: Donmez, Halil
name: Arslan, Bahar
name: Soyyigit, Sadan
name: Kara, Bilge Yilmaz
name: Karakis, Gulden Pasaoglu
name: Dursun, Adile Berna
name: Kendirlinan, Resat
name: Ozturk, Ayse Bilge
name: Sevinc, Can
name: Simsek, Gokcen Omeroglu
name: Abadoglu, Oznur
name: Cerci, Pamir
name: Yucel, Taskin
name: Yorulmaz, Irfan
name: Tezcaner, Zahide Ciler
name: Tatar, Emel Cadalli
name: Suslu, Ahmet Emre
name: Ozer, Serdar
name: Dursun, Engin
name: Celik, Gulfem Elif
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Considerable overlaps exist between asthma phenotypes and the clinical significance of these overlaps remains undetermined. The objective of this study is to analyze the characteristics of asthma overlap phenotypes using data from the Turkish Adult Asthma Registry (TAAR). This cross-sectional registry study included 2053 adult patients (74.8% female) with asthma. Overall, 39.3% (n = 697) had allergic–eosinophilic (AE), 26.0% (n = 461) had allergic–non-eosinophilic (ANE), 21.3% (n = 377) had non-allergic–eosinophilic (NAE), and 13.4% (n = 237) had non-allergic–non-eosinophilic (NANE) asthma. Severe asthma exacerbations and emergency department (ED) visits were more frequent in the AE (28.3%, 31.2%, respectively) and NAE groups (36.0%, 34.0%, respectively) than in the ANE (14.3%, 20.6%, respectively) and NANE groups (12.6%, 16.7%, respectively) (p &lt; 0.001). FEV1 values were significantly lower in the AE group than in the ANE and NANE groups (p &lt; 0.001, p = 0.048, respectively) and in the NAE group than in the ANE group (p &lt; 0.001). Risk factors for poor asthma control included living in rural areas, asthma-related ED visits, FEV1 &lt; 60% in the NAE; being overweight, chronic rhinosinusitis, oral corticosteroids use, age &lt; 40 years in the NANE; FEV1 &lt; 80% in the AE; and severe asthma exacerbations, ED visits for AE and ANE groups. The considerable overlap between allergic and eosinophilic asthma phenotypes has clinical implications as increased rates of asthma exacerbations and healthcare utilization. The clinical heterogeneity among asthma phenotypes based on a single biomarker highlights the importance of multidimensional asthma phenotyping.