cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Engineering of recombatinant antimalria antibodies for application in paratransgenesis
Creators: name: Anani, Bernard
Publisher: name: University of Westminster
Year: 2011

description: Malaria, transmitted by Anopheles mosquitoes is responsible for millions of deaths worldwide, especially in the developing countries. The emergence of drug resistant parasites and insecticide resistant vectors has stimulated efforts to develop novel genetic strategies to modify the insect vector and reduce its competence to transmit the parasite. One proposed approach is the genetic manipulation of insect’s midgut symbionts to express anti-parasite molecules. Recombinant antibodies that target specific antigens expressed on the parasites’ surface could be used as anti-parasite molecules, especially if they could not only bind but agglutinate the target. The murine antibody 4B7 binds to Pfs25 epitope expressed on the zygote and ookinette stages of the parasite. Pf-NPNA-1 is a human antibody that specifically binds to the NPNA (Asn-Pro-Asn-Ala) repeats of the circumsporozoite protein expressed on the sporozoite stage of the malaria parasite. This study aimed to characterise these antibodies for their application in symbiont control. For this purpose, the antibodies have been codon optimised for bacterial expression and formatted as single chain variable fragments (scFv). Synthetic genes encoding the scFv 4B7 and Pf-NPNA-1 were constructed, with varying linker length, in the VH-VL and VL-VH orientation. The scFvs were cloned into different expression plasmids to evaluate a suitable expression system. The orientation of the variable domains on secretion of the scFv 4B7 was investigated. No secretion was observed for the scFv 4B7 in the VH-VL orientation. For the reverse orientation, scFv 4B7 (VL-VH) was poorly secreted with no antigen binding. Secretion was observed for a variant of scFv 4B7 but this did not show significant antigen binding. Pf-NPNA-1 scFv constructs, in the VH-VL orientation, were efficiently secreted and showed detectable binding to antigen. Multimeric assembly of the scFv constructs was evaluated by varying the linker length. 4B7 and Pf-NPNA-1 scFv constructs exhibited monomeric, dimeric and multimeric assembly. Fusion of the human kappa constant domain to the scFvs resulted in formation of monomeric and higher ordered forms. Transfer of the scFv gene fragments into a broad-host vector facilitated evalution of recombinant antibody expression in the acetic acid bacterium, Asaia SF2.1. In summary, the results from this study demonstrate the potential utility of the antibodies, 4B7 and Pf-NPNA-1, as anti-parasite molecules for blockade of malaria transmission via mosquito midgut symbionts.
Fully Convolutional Neural Networks to Detect Clinical Dermoscopic Features
Creators: name: Kawahara, Jeremy
name: Hamarneh, Ghassan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: The presence of certain clinical dermoscopic features within a skin lesion may indicate melanoma, and automatically detecting these features may lead to more quantitative and reproducible diagnoses. We reformulate the task of classifying clinical dermoscopic features within superpixels as a segmentation problem, and propose a fully convolutional neural network to detect clinical dermoscopic features from dermoscopy skin lesion images. Our neural network architecture uses interpolated feature maps from several intermediate network layers, and addresses imbalanced labels by minimizing a negative multi-label Dice-F$_1$ score, where the score is computed across the mini-batch for each label. Our approach ranked first place in the 2017 ISIC-ISBI Part 2: Dermoscopic Feature Classification Task challenge over both the provided validation and test datasets, achieving a 0.895% area under the receiver operator characteristic curve score. We show how simple baseline models can outrank state-of-the-art approaches when using the official metrics of the challenge, and propose to use a fuzzy Jaccard Index that ignores the empty set (i.e., masks devoid of positive pixels) when ranking models. Our results suggest that (i) the classification of clinical dermoscopic features can be effectively approached as a segmentation problem, and (ii) the current metrics used to rank models may not well capture the efficacy of the model. We plan to make our trained model and code publicly available.
description: Accepted JBHI version
(502762) Elizabeth Ballantyne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Explicit polynomial sequences with maximal spaces of partial derivatives and a question of K. Mulmuley
Creators: name: Gesmundo, Fulvio
name: Landsberg, Joseph M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Complexity (cs.CC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 68Q15, 15A69

description: We answer a question of K. Mulmuley: In [Efremenko-Landsberg-Schenck-Weyman] it was shown that the method of shifted partial derivatives cannot be used to separate the padded permanent from the determinant. Mulmuley asked if this "no-go" result could be extended to a model without padding. We prove this is indeed the case using the iterated matrix multiplication polynomial. We also provide several examples of polynomials with maximal space of partial derivatives, including the complete symmetric polynomials. We apply Koszul flattenings to these polynomials to have the first explicit sequence of polynomials with symmetric border rank lower bounds higher than the bounds attainable via partial derivatives.
description: 18 pages - final version to appear in Theory of Computing
Additional file 1 of Testing, diagnosis, and treatment following the implementation of a program to provide dried blood spot testing for HIV and hepatitis C infections: the NSW DBS Pilot
Creators: name: Carrington, Nigel
name: Conway, Anna
name: Grebely, Jason
name: Starr, Mitchell
name: Catlett, Beth
name: Stevens, Annabelle
name: Prain, Bianca
name: McGrath, Colette
name: Causer, Louise
name: Guy, Rebecca
name: Holden, Joanne
name: Keen, Phillip
name: Kingsland, Melanie
name: Lu, Heng
name: Power, Cherie
name: Read, Phillip
name: Murray, Carolyn
name: McNulty, Anna
name: Cunningham, Philip
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Supplementary Figure 1. Visual aid contained in DBS sampling kit from December 2017. Supplementary Figure 2. HIV and HCV DBS screening laboratory testing algorithm.
Torsional Newton-Cartan gravity from the large $c$ expansion of General Relativity
Creators: name: Bleeken, Dieter Van den
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit the manifestly covariant large $c$ expansion of General Relativity, $c$ being the speed of light. Assuming the relativistic connection has no pole in $c^{-2}$, this expansion is known to reproduce Newton-Cartan gravity and a covariant version of Post-Newtonian corrections to it. We show that relaxing this assumption leads to the inclusion of twistless torsion in the effective non-relativistic theory. We argue that the resulting TTNC theory is an effective description of a non-relativistic regime of General Relativity that extends Newtonian physics by including strong gravitational time dilation.
description: 25 pages, v3 footnote on Kerr corrected, ref added
Transformations of photography in Japan (1990-1999)
Creators: name: Bohr, Marcus
Publisher: name: University of Westminster
Year: 2011

description: This dissertation examines photography in Japan via the new generation of young female photographers who emerged during the social, economic and political shifts of the post-bubble era (1990–1999). This new generation of photographers initiated a paradigmatic shift in photographic discourses within Japanese culture by becoming the subject of their own photographs, performing to the camera and deconstructing gender identities. The thesis holds a particular focus on the institutional setting where the work of female photographers first emerged and shows that most of the photographers discussed benefited from a system of corporate patronage. In turn, the emergence of female photographers is intimately linked with corporate interests such as the camera manufacturers. The legacy of this system of corporate patronage still greatly effects photographic discourse in Japan today. By focusing on the representation of the body, the thesis demonstrates that photographers interrogated public perceptions of obscenity defined in a specific cultural and historical context. While the sale and distribution of obscene images is prohibited by law, photographers tested the boundaries of permissible and non-permissible forms of representation. The thesis establishes that public perceptions of obscenity dramatically transformed throughout the 1990s, and that female photographers not only emerged on the back of this transformation, but also the fact that they were an integral part of it. The thesis demonstrates that both, the new generation of photographers and their photographs experienced a sharp rise in popularity in the Japanese media. Magazines and newspapers specifically called for and disseminated so-called ‘private photographs’ associated with the practice of female photographers. The increased media attention had the effect that some photographers themselves, in addition to their photographs, became valuable cultural signifiers in an image economy. The thesis describes a split in perception occurring between the ‘real’ female photographer, and the female photographer as a ‘sign’ characteristic for the social conditions this sign is produced and consumed in. In this context, the thesis defines the prominent notion kawaii, or cute, with reference to the practice of female photographers and how its ambiguous and paradoxical meanings constitute a floating signifier. Rather than concentrating on a photographic representation of cute, the thesis explores the potential of cuteness also bearing clues to opposition against a dominant social order. The thesis argues that both the accounts of the rise of the female photographers and an analysis of their photographs have to be inextricably linked to the social, economic and political conditions in which their photographs emerged.
(502761) Elizabeth Davidson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Impact of the Sars-Cov-2 outbreak on the initial clinical presentation of new solid cancer diagnoses: a systematic review and meta-analysis
Creators: name: Marty, Simon
name: Lamé, Guillaume
name: Guével, Etienne
name: Priou, Sonia
name: Chatellier, Gilles
name: Tournigand, Christophe
name: Kempf, Emmanuelle
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1: Figure S1. Location of included studies. Figure S2. Funnel plot for subgroup metastatic vs non-metastatic analysis on breast cancer. Table S1. Study characteristics. Table S2. Study quality assessment60. Table S3. Synthesis of first national lockdowns and cancer screening disruptions. Appendix S1. Pubmed and EMBASE search equations. Appendix S2. Inclusion and exclusion criteria for article selection. Appendix S3. List of data elements we extracted from included articles. Appendix S4. Classification of primary cancer types.
Automated kinetic parameter optimization of catalytic reactions using Basin-Hopping
Creators: name: Rinu Chacko
name: Keller, Kevin
name: Tischer, Steffen
name: Shirsath, Akash B.
name: Lott, Patrick
name: Deutschmann, Olaf
Publisher: name: Zenodo
Year: 2023

description: Poster presented at the Annual Meeting on Reaction Engineering 2023 at Frankfurt during 15-17 May 2023.
Functional characteristics and subjective disease perception in patients with COVID-19 two months after hospital discharge
Creators: name: Teraž, Kaja
name: Šimunič, Boštjan
name: Peskar, Manca
name: Marusic, Uros
name: Pišot, Saša
name: Šlosar, Luka
name: Gasparini, Malden
name: Pišot, Rado
Publisher: name: Technische Universität Berlin
Year: 2023
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
subject: coronavirus
subject: recovery
subject: functional improvement
subject: hospital stay
subject: health perception

description: Introduction: Although early inpatient and post-hospital rehabilitation is recognized as necessary, not all COVID-19 patients have access to rehabilitation. There are no published reports in the literature that investigate the outcomes of patients who do not receive rehabilitation after COVID-19. Our aim was to evaluate possible improvements in determinate functional and psychological parameters in COVID-19 patients two months after their hospital discharge. Methods: On both time points various motor, cognitive, and clinical measurements such as body composition, tensiomyography, blood pressure, spirometry, grip strength test, Timed Up and Go test, gait speed, 30-second chair-stand test, and Montreal Cognitive Assessment, were performed. Additionally, questionnaires such as the SARC-CalF test, Edmonton frail scale, International Physical Activity questionnaire andThe Mediterranean Lifestyle index were conducted to assess lifestyle characteristics. Results: A total of 39 patients (87.2% male; mean age of 59.1 ± 10.3 years), who were hospitalized due to COVID-19 at the Izola General Hospital (IGH), Slovenia between December 2020 and April 2021, were included. Patients were assessed at two time points (T1 and T2): T1 was taken after receiving a negative COVID-19 test and T2 was taken two months after T1. After two months of self-rehabilitation, we have detected a BMI increase (p < .001), fat free mass increase (p < .001), better Edmonton frail scale (p < .001), SARC-CalF score (p = .014) and MoCA score (p = .014). There were no detected changes in lifestyle habits nor in physical performance tests. Discussion: It is already known that COVID-19 has long-term negative consequences regardless of the stage of the disease. Our findings support the notion that patients cannot fully regain all their functions within a two-month period without receiving structured or supervised rehabilitation. Therefore, it is crucial to offer patients comprehensive and structured rehabilitation that incorporates clinical, cognitive, and motor exercises.
Archaeological Assesssment of the Trent-Soar Confluence Zone
Creators: name: Cooper, Lynden
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 80, 1-26
description: An assessment of the archaeological resource at the confluence of the rivers Trent and Soar offered an opportunity to present a synthesis of an evolving archaeological landscape. The study area contains sites of both national and local significance including the late prehistoric ritual monument complex at Lockington, and major Iron Age and Roman sites at Red Hill and Lockington. Within the flood-plain are important prehistoric structures and artefacts from Aston on Trent and the water-logged medieval remains at Hemington quarry. The overarching theme of this multi-period study is the confluence zone as an important nodal point in the transport and communications systems from prehistory to the present.
(502760) Walter Ballantyne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantitative analysis of molecular interactions between erythrosine B and cationic surfactants: liquid crystal-based sensor design for the efficient determination of erythrosine B
Creators: name: Mohseni-Shahri, Fatemeh S.
name: Moeinpour, Farid
name: Verdian, Asma
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Erythrosine B (EB) is a xanthene dye widely used in many fields such as food, cosmetics and medicine. The interaction between EB and cetyltrimethylammonium bromide (CTAB) was investigated using spectrophotometry. The quantities of the quenching constant of Stern-Volmer, the number of binding sites and the binding constant were calculated for the EB-CTAB system. Liquid crystal-based sensing platform (LC) developed for ultrasensitive and unlabelled EB determination using an LC interface decorated with cationic surfactants. Nematic liquid crystals exposed to CTAB exhibited homeotropic binding, when EB was inserted into LC cells, and the inward arrangement was thus changed to a coplanar shape by electrostatic interaction between CTAB and EB. The sensor was developed based on LC which recognised EB at tracking level too low, up to 2.0 pM. The proposed LC-based sensing system is a quick, comfortable and easy approach for the determination of EB in unlabelled biological samples.
Leicestershire Sites and Monuments Record at the Crossroads
Creators: name: P Jarrett, Robert
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 64, 78-82
description: The practice of keeping central records on all aspects of a county's archaeological knowledge is one which has come into being comparatively recently. Before the 1960s, the accumulation of information was dispersed amongst many bodies, e.g. county archaeological units, museums, universities, county planning departments, and sometimes even private individuals. The 'old archaeology', being more concerned with artefacts, did at least recognise the need to bring together information for a given geographical area; the obsession with distribution maps shows this very clearly. With the post-war development boom it became increasingly necessary to assess, quickly and easily, from one given record, the archaeological potential of any given place. Thus the concept of the Sites and Monuments Record (hereafter SMR) was born.
Deuterated Liquid Crystals - design and synthesis of deuterium labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls using batch and continuous flow systems
Creators: name: Zak, Marta
name: Herman, Jakub
name: Czerwiński, Michał
name: Arakawa, Yuki
name: Tsuji, Hideto
name: Kula, Przemysław
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The high interest of isotopically labelled compounds is induced by two important factors: (i) improvement of highly sensitive and precise analytical methods for isotope identification and (ii) development of new synthetic approaches for isotopically labelled compounds. However, there is still a lack of efficient and cheap methods for the design of deuterium labelled liquid crystalline materials. Herein, the continuous flow system was adapted for the synthesis of deuterated Liquid Crystals using the H-Cube Pro reactor, where deuterium gas was generated in situ from heavy water. We designed and developed the synthesis of homologous series of 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls where deuterium atoms are placed at carbon α and carbon β positions or only at carbon α positions of alkyl terminal chains. The synthetic strategy involves mainly selective deuteration reactions of C≡C bonds as well as reduction of carbonyl groups C=O using batch or continuous flow conditions. Theoretical calculation and experimental study show that deuterium labelled Liquid Crystals exhibit increased photochemical stability compared to protonated ones. Moreover, the comparison of physicochemical properties between deuterium labelled and non-labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls is presented. This work provides efficient methods to obtain deuterated liquid crystalline materials with much better photochemical stability compared to their fully protonated isotopologues.
5ta Reunión General de la RedGobMet 2021. Jornadas para la Cocreación de la Agenda de Estudio
Creators: name: Navarrete Ulloa, Carlos Alberto
name: Guevara Castillo, Álvaro Ángel
Publisher: name: Zenodo
Year: 2021
Subjects: Cocreación
Transdisciplina
Talleres de cocreación
Metodología cocreativa

description: Presenta el programa de actividades y participantes de la V Reunión General de la Red Temática Gobernanza Metropolitana, celebrada en las instalaciones de El Colegio de Jalisco y simultaneamente con participaciones viruales en plataforma Zoom. El objetivo del evento fue "Actualizar la agenda de estudio de la Red Temática Gobernanza Metropolitana , mediante una metodología cocreativa, que transversalice la identificación y disusión de los temas necesarios para una agenda de investigación-incidencia para los siguientes años". Inluye enlace a la conferencia inagural dictada por el Dr. Luis F. Aguilar Villanueva
description: El evento se organizó con el apoyo de El Colegio de Jalisco. Agradecemos la participación en el equipo de organización a Cristina Lizárraga, Celene Valadez y Anakaren Hernández.
Stabilization Bounds for Linear Finite Dynamical Systems
Creators: name: Lindenberg, Björn
Publisher: name: arXiv
Year: 2017
Subjects: subject: Dynamical Systems (math.DS)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 05C50, 13M99, 13P99, 37P25

description: A common problem to all applications of linear finite dynamical systems is analyzing the dynamics without enumerating every possible state transition. Of particular interest is the long term dynamical behaviour. In this paper, we study the number of iterations needed for a system to settle on a fixed set of elements. As our main result, we present two upper bounds on iterations needed, and each one may be readily applied to a fixed point system test. The bounds are based on submodule properties of iterated images and reduced systems modulo a prime. We also provide examples where our bounds are optimal.
description: 16 pages, 5 figures
(502759) [?] Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A simple extension of SM that can explain the $(g-2)_μ$ anomaly, small neutrino mass and a dark-matter
Creators: name: Dhargyal, Lobsang
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we propose a simple extension of standard-model (SM) by adding eleven new particles to it. Three heavy leptons ($f_{e},\ f_μ,\ f_τ$) singlet under the $SU(3)_{c}\times SU(2)_{L}$ carrying respective Lepton-Numbers, charged under the $U(1)_{Y}$ with $Y = -2$ and transforming under a discrete symmetry as $f_{i} \rightarrow -f_{i}$. One scalar ($ϕ_{2}$), singlet under all the SM gauge groups and transforming under the discrete symmetry as $ϕ_{2} \rightarrow -ϕ_{2}$ which does not develops a non zero vacuum-expectation-value (VEV). One more scalar ($ϕ_{3}$), singlet under all the SM gauge groups and invariant under the discrete symmetry which develops a non zero VEV ($v_{3}$) and gives masses to $f_{i}$s, $ϕ_{2}$ and neutrinos. Three right-handed neutrinos ($ν_{iR}$) and three left-handed Majorana neutrinos ($s_{iL}$). With these new additional particles added to SM we have been able to give explanations to the long standing muon (g -2) anomaly as well as the smallness of neutrino masses by the inverse see-saw mechanism. And also in this model we have a very suitable scalar dark-matter (DM) candidate in $ϕ_{2}$ with allowed mass as high as 53 GeV, although due to large Yukawa coupling required to explain the muon (g-2), its contribution to the DM relic density turn out to be too small and so it can account only a small fraction of the DM relic density of the universe.
description: Minor typos corrected to "J.Phys. G45 (2018) no.7, 075002. DOI: 10.1088/1361-6471/aac40a" in Table 1
Additional file 1 of Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway
Creators: name: Yoo, Ahyoung
name: Kim, Jung-In
name: Lee, Hyunjung
name: Nirmala, Farida S.
name: Hahm, Jeong-Hoon
name: Seo, Hyo Deok
name: Jung, Chang Hwa
name: Ha, Tae Youl
name: Ahn, Jiyun
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Antibody for western blot. Figure S1. Comparative effect of 50% and 80% ethanol GW extract on Dexa-induced muscle atrophy in C2C12 cells. Figure S2. Cytotoxic effect of GW and lithospermic acid on C2C12 cells.
Synchronised flexoelectric instability in an LC cell with periodic planar-homeotropic alignment
Creators: name: Simdyankin, Ivan Vladimirovich
name: Geivandov, Artur Rubenovich
name: Umanskii, Boris Aleksandrovich
name: Palto, Serguei Petrovich
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In a planarly aligned layer of a nematic liquid crystal (LC) the applied electric field can induce a periodic stripe pattern, which is characteristic of the well-known flexoelectric instability effect. We have studied the flexoelectric instability in LC layers with periodic planar-homeotropic alignment (PHA) at one of the layer surfaces and compared the results to the case of the homogeneously aligned layer. It is found that the PHA is more favourable for the flexoelectric spatial modulation. The flexoelectric grating is formed significantly faster in the case of short-period PHA as compared to the cell with homogeneous alignment, which is due to both PHA periodicity and flexoelectric polarisation that in the case of PHA is non-zero even in the field-off state. The impressive finding is that the flexoelectric gratings are spatially synchronised with PHA and free of fork-like defects. The Fourier analysis of the patterns shows that the wavenumber of the flexoelectric gratings is multiple of the PHA grating wavenumber, which points to the spatial resonance of the flexoelectric instability with the PHA harmonics. The improved dynamics with the synchronisation opens perspectives for new electrooptical and photonic applications of the flexoelectric gratings.
Automation of Interdisciplinary Research Data Management for Catalysis
Creators: name: Riedel, Johannes
name: Rinu Chacko
name: Angeli, Sofia
name: Goßler, Hendrik
name: Daymo, Eric
name: Deutschmann, Olaf
Publisher: name: Zenodo
Year: 2022

description: Poster presented at the Annual Digital Catalysis & Catalysis-Related Sciences Conference 2022 held at Frankfurt on 23rd September 2022.
Efficient Second Order Unconditionally Stable Schemes for a Phase-field Moving Contact Line Model Using Invariant Energy Quadratization Approach
Creators: name: Yang, Xiaofeng
name: Yu, Haijun
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65M12, 65Z05, 65P40

description: We consider the numerical approximations for a phase field model consisting of incompressible Navier--Stokes equations with a generalized Navier boundary condition, and the Cahn-Hilliard equation with a dynamic moving contact line boundary condition. A crucial and challenging issue for solving this model numerically is the time marching problem, due to the high order, nonlinear, and coupled properties of the system. We solve this issue by developing two linear, second order accurate, and energy stable schemes based on the projection method for the Navier--Stokes equations, the invariant energy quadratization for the nonlinear gradient terms in the bulk and boundary, and a subtle implicit-explicit treatment for the stress and convective terms. The well-posedness of the semidiscretized system and the unconditional energy stabilities are proved. Various numerical results based on a spectral-Galerkin spatial discretization are presented to verify the accuracy and efficiency of the proposed schemes.
Hyperinflation
Creators: name: Brown, Adam R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A model of cosmological inflation is proposed in which field space is a hyperbolic plane. The inflaton never slow-rolls, and instead orbits the bottom of the potential, buoyed by a centrifugal force. Though initial velocities redshift away during inflation, in negatively curved spaces angular momentum naturally starts exponentially large and remains relevant throughout. Quantum fluctuations produce perturbations that are adiabatic and approximately scale invariant; strikingly, in a certain parameter regime the perturbations can grow double-exponentially during horizon crossing.
description: published as "Hyperbolic Inflation"
Pauperism and the Leicester Workhouse in 1881
Creators: name: Page, Stephen
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 63, 85-95
description: In this paper, the problem of poverty in Victorian Leicester is examined using evidence from the Poor Law which was the main agency responsible for the social well-being of the poor. The Poor Law dealt with the extreme cases of poverty and destitute poor and forms a useful medium for understanding who cared for the poor's welfare. As Rose has confirmed 'urban poverty was a wide phenomena which embraced, at some stage in their lives, many nineteenth century town dwellers. Thus the potential urban clientele of the Poor Law system was an enormous one'. Therefore, using the transcripts of the 1881 census of Leicester Workhouse, it is possible to assess 'who the poor were', 'their social and economic characteristics' and, 'their geographical origins'. However, to understand the significance of the Poor Law in assisting the poor it is necessary to explain how it operated and its rationale for relieving hardship and distress.
Deuterated Liquid Crystals - design and synthesis of deuterium labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls using batch and continuous flow systems
Creators: name: Pytlarczyk, Marta
name: Herman, Jakub
name: Czerwiński, Michał
name: Arakawa, Yuki
name: Tsuji, Hideto
name: Kula, Przemysław
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The high interest of isotopically labelled compounds is induced by two important factors: (i) improvement of highly sensitive and precise analytical methods for isotope identification and (ii) development of new synthetic approaches for isotopically labelled compounds. However, there is still a lack of efficient and cheap methods for the design of deuterium labelled liquid crystalline materials. Herein, the continuous flow system was adapted for the synthesis of deuterated Liquid Crystals using the H-Cube Pro reactor, where deuterium gas was generated in situ from heavy water. We designed and developed the synthesis of homologous series of 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls where deuterium atoms are placed at carbon α and carbon β positions or only at carbon α positions of alkyl terminal chains. The synthetic strategy involves mainly selective deuteration reactions of C≡C bonds as well as reduction of carbonyl groups C=O using batch or continuous flow conditions. Theoretical calculation and experimental study show that deuterium labelled Liquid Crystals exhibit increased photochemical stability compared to protonated ones. Moreover, the comparison of physicochemical properties between deuterium labelled and non-labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls is presented. This work provides efficient methods to obtain deuterated liquid crystalline materials with much better photochemical stability compared to their fully protonated isotopologues.
Packing Short Plane Spanning Graphs in Complete Geometric Graphs
Creators: name: Aichholzer, Oswin
name: Hackl, Thomas
name: Korman, Matias
name: Pilz, Alexander
name: Rote, Günter
name: van Renssen, André
name: Roeloffzen, Marcel
name: Vogtenhuber, Birgit
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Geometry (cs.CG)
subject: FOS: Computer and information sciences

description: Given a set of points in the plane, we want to establish a connection network between these points that consists of several disjoint layers. Motivated by sensor networks, we want that each layer is spanning and plane, and that no edge is very long (when compared to the minimum length needed to obtain a spanning graph). We consider two different approaches: first we show an almost optimal centralized approach to extract two graphs. Then we show a constant factor approximation for a distributed model in which each point can compute its adjacencies using only local information. In both cases the obtained layers are plane
description: Preliminary version appeared in the proceedings of the 27th International Symposium on Algorithms and Computation (ISAAC 2016), Leibniz International Proceedings in Informatics (LIPIcs), Vol. 64, pp. 9:1-9:12
Additional file 1 of A qualitative analysis of free-text patient satisfaction responses in Care Response, a database of patient-reported outcome and experience measures
Creators: name: Young, Kenneth J.
name: Young, Helen C.
name: Field, Jonathan
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1. Quotes representative of the different uses of each of the top 20 most common words entered into the “good points” and “improvements” boxes on the Care Response database.
Emigration and Poverty in Edwardian Leicester
Creators: name: Page, Stephen
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 65, 68-84
description: This paper argues that any assessment of the poor who emigrated requires an in-depth study to understand the diversity of human experiences associated with the decision to emigrate, often a last resort to alleviate personal hardship and deprivation. Using case histories generated by the Leicester Charity Organisation Society, this paper focuses on their philanthropic activities in assisting the 'deserving poor' to emigrate and their detailed investigative procedures which provide a unique insight into the lives of the poor in Edwardian Leicester.
Slides presented at CoRDI - Digitalization in Catalysis and Reaction Engineering: Automatizing workflows
Creators: name: Rinu Chacko
name: Goßler, Hendrik
name: Riedel, Johannes
name: Schunk, Stephan Andreas
name: Deutschmann, Olaf
Publisher: name: Zenodo
Year: 2023

description: Presentation slides for the talk given at the 1st Conference on Research Data Infrastructure on 12th September 2023 held in Karlsruhe.
Additional file 1 of Assessment of the intrasinusidal volume before and after maxillary sinus augmentation using mri – a pilot study of eight patients
Creators: name: Flick, K.
name: Smeets, R.
name: Gosau, M.
name: Meyer, L.
name: Hanning, U.
name: Kyselyova, A. A.
name: Scheifele, C.
name: Höhmann, B.
name: Henningsen, A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1.
Lodging and Poverty in late Victorian Leicester
Creators: name: Page, Stephen
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 68, 121-144
description: This paper examines a hitherto neglected aspect of urban society in late Victorian Leicester, the relationship between lodging and poverty. It is argued that during a period of rapid industrialisation in which labour force requirements were met through in-migration, certain sections of the population experienced the problem of adapting to an urban industrial lifestyle. The role of lodgers and lodging are considered within the context of the socialisation process which enabled people to settle into urban life. Lodging also provided an important source of income for certain households to stave off poverty. These issues are examined using evidence from a sample of the 1881 Census Enumerators Books and impressionistic reports relating to the process of lodging in mid-Victorian Leicester which provide evidence of middle-class concern for common lodging-houses.
New solar metallicity measurements
Creators: name: Vagnozzi, Sunny
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In the past years, a systematic downward revision of the metallicity of the Sun has led to the "solar modeling problem", namely the disagreement between predictions of standard solar models and inferences from helioseismology. Recent solar wind measurements of the metallicity of the Sun, however, provide once more an indication of a high-metallicity Sun. Because of the effects of possible residual fractionation, the derived value of the metallicity $Z_{\odot} = 0.0196 \pm 0.0014$ actually represents a lower limit to the true metallicity of the Sun. However, when compared with helioseismological measurements, solar models computed using these new abundances fail to restore agreement, owing to the implausibly high abundance of refractory (Mg, Si, S, Fe) elements, which correlates with a higher core temperature and hence an overproduction of solar neutrinos. Moreover, the robustness of these measurements is challenged by possible first ionization potential fractionation processes. I will discuss these solar wind measurements, which leave the "solar modeling problem" unsolved.
description: 6 pages, extended version of contribution to proceedings of the 51st Rencontres de Moriond, Cosmology Session, published as communication in Atoms
Detecting Adversarial Image Examples in Deep Networks with Adaptive Noise Reduction
Creators: name: Liang, Bin
name: Li, Hongcheng
name: Su, Miaoqiang
name: Li, Xirong
name: Shi, Wenchang
name: Wang, Xiaofeng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Recently, many studies have demonstrated deep neural network (DNN) classifiers can be fooled by the adversarial example, which is crafted via introducing some perturbations into an original sample. Accordingly, some powerful defense techniques were proposed. However, existing defense techniques often require modifying the target model or depend on the prior knowledge of attacks. In this paper, we propose a straightforward method for detecting adversarial image examples, which can be directly deployed into unmodified off-the-shelf DNN models. We consider the perturbation to images as a kind of noise and introduce two classic image processing techniques, scalar quantization and smoothing spatial filter, to reduce its effect. The image entropy is employed as a metric to implement an adaptive noise reduction for different kinds of images. Consequently, the adversarial example can be effectively detected by comparing the classification results of a given sample and its denoised version, without referring to any prior knowledge of attacks. More than 20,000 adversarial examples against some state-of-the-art DNN models are used to evaluate the proposed method, which are crafted with different attack techniques. The experiments show that our detection method can achieve a high overall F1 score of 96.39% and certainly raises the bar for defense-aware attacks.
description: 14 pages, http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8482346&isnumber=4358699
(502758) [?] Athey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET
Creators: name: Narciso, Lucas
name: Deller, Graham
name: Dassanayake, Praveen
name: Liu, Linshan
name: Pinto, Samara
name: Anazodo, Udunna
name: Soddu, Andrea
name: Lawrence, Keith St
Publisher: name: figshare
Year: 2024
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1. Supplementary Figures and Tables.
Housing the Leicester Framework Knitters
Creators: name: Palmer, Marilyn
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 74, 59-78
description: The city of Leicester has owed much of its prosperity to the hosiery trade since the 17th century. This paper uses both physical evidence and documentary sources to investigate where stockings were made, from the adapted houses of the 17th and early 18th centuries to the purpose-built terraced rows of houses incorporating workshops in the late 18th and 19th centuries. Finally, the paper considers the slow transition to powered production, transferring the industry from the domestic environment to the close-packed factories which are still a feature of many Leicester streets today.
An Emergency Excavation at Appleby Magna Church Leicestershire
Creators: name: Parsons, David
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 50, 41-45
description: In June 1975 it became known that the Parochial Church Council of Appleby Magna was about to embark, on the advice of its architects, on a campaign to alleviate the dampness in the outer walls of the church of St Michael and All Angels. A major item in this campaign was to be the improvement of the exterior drainage by the excavation of a trench for a perforated plastic pipe around the walls of the church; the proposed trench was to be approximately 0.50 m. (1 ft 8 in.) wide and up to 1.00 m. (3 ft 3 in.) deep, and dug directly against the north and south aisle walls, following a sinuous route to avoid the buttresses. From the archaeological point of view this proposal constituted a threat of the most serious kind, to which attention has been drawn in a recent publication of the Council for Places of Worship.