cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Tahap Profesionalisme Guru Sekolah Rendah Agama Jabatan Agama Islam Wilayah Persekutuan Terhadap Amalan Perlaksanaan Pengajaran
Creators: name: Mohd Nawi, Muhammad Zulazizi
Publisher: name: figshare
Year: 2022
Subjects: subject: 130313 Teacher Education and Professional Development of Educators
subject: FOS: Educational sciences

description: This study aims to examine the level of professionalism of religious primary school teachers of the Federal Territory Islamic Religious Department (JAWI) on the practice of teaching implementation. This study involved 274 teachers of Religious Primary School (SRA) JAWI in the Federal Territory of Kuala Lumpur. Quantitative data using a questionnaire instrument were analyzed descriptively using Statistical Package for the Social Sciences (SPSS) version 22 to obtain the frequency, percentage, mean, interpretation, and standard deviation. The results of the study on the level of professionalism of religious primary school teachers of the Federal Territory Islamic Religious Department (JAWI) on the practice of teaching implementation recorded a high level (M=4.20, S.D = 0.26). Indeed, the level of professionalism of SRA-JAWI teachers towards the practice of teaching implementation is positive but has weaknesses in terms of the application of computers in teaching. Thus, while conducting the teaching process, a teacher must take into account the constraints encountered while using ICT in teaching sessions to be applied and the readiness of teachers to do ICT-based teaching in order to be more effective. In conclusion, the study shows that the level of professionalism of SRA-JAWI teachers on the practice of teaching implementation is very good
Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: To quantify the effect of the apolipoprotein (apo) E polymorphism on the magnitude of postprandial lipemia, the authors have defined its role in determining the response to a single high-fat meal in a large sample of (N = 474) individuals taking part in the biethnic Atherosclerosis Risk in Communities Study. The profile of postprandial response in plasma was monitored over 8 h by triglyceride, triglyceride-rich lipoprotein (TGRL)-triglyceride, apo B-48/apo B-100 ratio, and retinyl palmitate concentrations, and the apo E polymorphism was determined by DNA amplification and digestion. The frequency of the apo E alleles and their effects on fasting lipid levels in this sample with vitamin A was significantly different among apo E genotypes, with delayed clearance in individuals with an [var epsilon]2 allele, compared with [var epsilon]3/3 and [var epsilon]3/4 individuals. In the sample of 397 Caucasians, average retinyl palmitate response was 1,489 [mu]g/dl in [var epsilon]2/3 individuals, compared with 1,037 [mu]g/dl in [var epsilon]3/3 individuals and 1,108 [mu]g/dl in [var epsilon]3/4 individuals. The apo E polymorphism accounted for 7.1% of the interindividual variation in postprandial retinyl palmitate response, a contribution proportionally greater than its well-known effect on fasting LDL-cholesterol. However, despite this effect on postprandial retinyl palmitate, themore » profile of postprandial triglyceride response was not significantly different among apo E genotypes. The profile of postprandial response was consistent between the sample of Caucasians and a smaller sample of black subjects. While these data indicate that the removal of remnant particles from circulation is delayed in subjects with the [var epsilon]2/3 genotype, there is no reported evidence that the [var epsilon]2 allele predisposes to coronary artery disease (CAD). 82 refs., 6 figs., 4 tabs.« less
Object-verb agreement
Creators: name: Moravcsik, Edith A.
Publisher: name: Zenodo
Year: 1974
Subjects: object agreement, verb agreement, language universals

description: Some cross-linguistically valid observations about verb agreement patterns are presented, especially as related to the agreement of the verb and the direct object. Questions about the relationship of these statements to observable linguistic reality, about their significance, and about their explanations are raised.
Non-Mendelian transmission in a human developmental disorder: split hand/split foot.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: The study of Mendelian disorders that do not meet some Mendelian expectations has led to an increased understanding of such previously obscure genetic phenomena as anticipation. Split hand/split foot (SHSF), a human developmental malformation, demonstrates such distinctive genetic features as reduced penetrance and variable expressivity. In this study, new pedigrees with defined ascertainment confirm the existence of non-Mendelian transmission characterized by the overtransmission of SHSF from affected fathers to sons.
Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: A novel point mutation in the lysosomal acid sphingomyelinase gene has been identified in the recently reported Serbian family with a clinically and biochemically atypical intermediate form of Niemann-Pick disease. The mutation was a T1171-->G transversion resulting in substitution of glycine for normal tryptophan at amino acid residue 391. The coding sequence was otherwise normal. All of the five affected individuals were almost certainly homoallelic, and both of the two obligate heterozygotes studied also carried the same mutation. This mutation is therefore likely to be directly associated with the atypical phenotype of these patients. Expression in COS-1 cells suggested a higher residual activity than that in cultured fibroblasts. A recently developed high-affinity rabbit antihuman sphingomyelinase antibody allowed us to study for the first time the biosynthesis, processing, and targeting of a mutant sphingomyelinase by metabolic labeling of cultured fibroblasts. The mutant enzyme protein was normally synthesized, processed, and routed to the lysosome but was apparently unstable and degraded rapidly once it reached the lysosome. Together with the finding of the relatively high residual activity in COS-1 cells, we interpret our observations to mean that instability and rapid breakdown of the mature mutant enzyme protein, due to the mutation rather than direct inactivation of the catalytic activity, is the primary mechanism for the deficiency of sphingomyelinase activity in these patients. A high prevalence of this mutation in the Serbian population is likely, since the family pedigree indicates that members from four reportedly unrelated families must have contributed the same mutation.
Vers une phénoménologie de la normativité. Une circonscription préliminaire du domaine
Creators: name: Alves, Pedro
Publisher: name: Phenomenology and Mind
Year: 2017

description: I discuss, from a phenomenological point of view, the distinction between judgments and norms. I stress the limits of the Husserlian canonical analysis in order to rightly account for the sense and content of normative intentionality. Based on some Kelsenian insights, I draw a clear distinction between judgments and norms, criticizing some classical trends coming from Husserl himself that consider norms as a kind of intentionality founded upon objectifying acts. However, taking distance from Kelsen, Kaufmann, and Cossio, I stress that the ought-proposition (Sollsatz) cannot be a good rendering of the sense-content of norms, based on the phenomenological distinction between the intentional matter and the quality of intentional acts. Finally, I propose my own account based on the concept of “ductive force”. I stress that the ductive force of norms cannot be identified with simple coercion. I show that there is, even inside the juridical sphere, a variety of ductive forces, going from sheer coercion to council and recommendation. To end, I stress the centrality of the concept of “ductive force” for a phenomenology of the social world.
description: Phenomenology and Mind, No 13 (2017): Norm: What Is It? Ontological and Pragmatical Perspectives
Supplementary Material for 'Mean structure of the supercritical turbulent spiral regime in Taylor-Couette flow' from Mean structure of the supercritical turbulent spiral in Taylor–Couette flow
Creators: name: Wang, B.
name: Mellibovsky, F.
name: Ayats, R.
name: Deguchi, K.
name: Meseguer, A.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: 91504 Fluidisation and Fluid Mechanics
subject: FOS: Other engineering and technologies

description: The large-scale laminar/turbulent spiral patterns that appear in the linearly unstable regime of counter-rotating Taylor–Couette flow are investigated from a statistical perspective by means of direct numerical simulation. Unlike the vast majority of previous numerical studies, we analyse the flow in periodic parallelogram-annular domains, following a coordinate change that aligns one of the parallelogram sides with the spiral pattern. The domain size, shape and spatial resolution have been varied and the results compared with those in a sufficiently large computational orthogonal domain with natural axial and azimuthal periodicity. We find that a minimal parallelogram of the right tilt significantly reduces the computational cost without notably compromising the statistical properties of the supercritical turbulent spiral. Its mean structure, obtained from extremely long time integrations in a co-rotating reference frame using the method of slices, bears remarkable similarity with the turbulent stripes observed in plane Couette flow, the centrifugal instability playing only a secondary role.This article is part of the theme issue ‘Taylor–Couette and related flows on the centennial of Taylor’s seminal Philosophical transactions paper (Part 2)’.
The Imperative of Reputation Between Social and Moral Norms
Creators: name: Terravecchia, Gian Paolo
Publisher: name: Phenomenology and Mind
Year: 2017

description: For the philosophy of normativity, the study of reputation helps a better understanding of the conflict that may arise between social and moral norms. It is a conflict which has been discussed in recent years and which has never been treated specifically from this perspective before. The paper discusses the dilemma, firstly showing its roots and meanings and secondly giving the reasons to choose one of the alternatives. This helps to show the normative conflict between social and moral norms and to explore its complexity, presenting some solutions. In so doing, the ontology of reputation is developed and discussed, also by presenting and discussing the two forms of the imperative of reputation.
description: Phenomenology and Mind, No 13 (2017): Norm: What Is It? Ontological and Pragmatical Perspectives
Beyond extended dynamical mean-field theory: Dual boson approach to the two-dimensional extended Hubbard model
Creators: name: van Loon, Erik G. C. P.
name: Lichtenstein, Alexander I.
name: Katsnelson, Mikhail I.
name: Parcollet, Olivier
name: Hafermann, Hartmut
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The dual boson approach [Ann. Phys. 327, 1320 (2012)] provides a means to construct a diagrammatic expansion around the extended dynamical mean-field theory (EDMFT). In this paper, we present the numerical implementation of the approach and apply it to the extended Hubbard model with nearest-neighbor interaction $V$. We calculate the EDMFT phase diagram and study the effect of diagrams beyond EDMFT on the transition to the charge-ordered phase. Including diagrammatic corrections to the EDMFT polarization shifts the EDMFT phase boundary to lower values of $V$. The approach interpolates between the random phase approximation in the weak coupling limit and EDMFT for strong coupling. Neglecting vertex corrections leads to results reminiscent of the EDMFT+$GW$ approximation. We however find significant deviations from the dual boson results already for small values of the interaction, emphasizing the crucial importance of fermion-boson vertex corrections.
description: Published version; 24 pages, 32 figures
Long Range Beam-beam Effects in the LHC
Creators: name: Herr, W.
name: Buffat, X.
name: Calaga, R.
name: Giachino, R.
name: Papotti, G.
name: Pieloni, T.
name: Kaltchev, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We report on the experience with long-range beam--beam effects in the LHC, in dedicated studies as well as the experience from operation. Where possible, we compare the observations with the expectations.
description: Presented at the ICFA Mini-Workshop on Beam-Beam in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 March 2013
Art and Entanglement in Strange Tools
Creators: name: Noë, Alva
Publisher: name: Phenomenology and Mind
Year: 2018

description: What is art? Why does it matter? What does it tell us about ourselves? In this essay, I introduce and in some cases extend the basic account of these matters offered in Strange Tools (New York, Hill and Wang: 2016).
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Precision Electroweak Analysis after the Higgs Boson Discovery
Creators: name: Wells, James D.
name: Zhang, Zhengkang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Until recently precision electroweak computations were fundamentally uncertain due to lack of knowledge about the existence of the Standard Model Higgs boson and its mass. For this reason substantial calculational machinery had to be carried along for each calculation that changed the Higgs boson mass and other parameters of the Standard Model. Now that the Higgs boson is discovered and its mass is known to within a percent, we are able to compute reliable semi-analytic expansions of electroweak observables. We present results of those computations in the form of expansion formulae. In addition to the convenience of having these expressions, we show how the approach makes investigating new physics contributions to precision electroweak observables much easier.
description: 23 pages, 8 tables. v2: a mistake corrected. v3: typos corrected
Ways of Perceiving and Mapping Human Cognition through Art
Creators: name: Mortu, Ancuta
Publisher: name: Phenomenology and Mind
Year: 2018

description: This paper discusses the question of how art might reveal important aspects of human cognition by taking as a starting point Alva Noë’s book Strange Tools. Art and Human Nature (2015). I argue that the enactive approach defended in this book has strong affinities with some recent art-historical approaches that take their cue from cognitive neuroscience, such as neuroarthistory (Onians, 2016). My main claim is that the extended mind thesis, which is implied in both approaches, fails to capture important aspects of the cognitive underpinnings of artistic practices. Finally, I bring into focus Noë’s ambiguous position with respect to the role of perception in aesthetic appreciation. What good comes from distinguishing between various ways of seeing while at the same time holding that art appreciation is a matter of value and judgment rather than perception and response?
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Unusual Flaring Activity in the Blazar PKS 1424-418 during 2008-2011
Creators: name: Buson, S.
name: Longo, F.
name: Larsson, S.
name: Cutini, S.
name: Finke, J.
name: Ciprini, S.
name: Ojha, R.
name: D'Ammando, F.
name: Donato, D.
name: Thompson, D. J.
name: Desiante, R.
name: Bastieri, D
name: Wagner, S.
name: Hauser, M.
name: Fuhrmann, L.
name: Dutka, M.
name: Müller, C.
name: Kadler, M.
name: Angelakis, E.
name: Zensus, J. A.
name: Stevens, J.
name: Blanchard, J. M.
name: Edwards, P. G.
name: Lovell, J. E. J.
name: Gurwell, M. A.
name: Wehrle, A. E.
name: Zook, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Context. Blazars are a subset of active galactic nuclei (AGN) with jets that are oriented along our line of sight. Variability and spectral energy distribution (SED) studies are crucial tools for understanding the physical processes responsible for observed AGN emission. Aims. We report peculiar behaviour in the bright gamma-ray blazar PKS 1424-418 and use its strong variability to reveal information about the particle acceleration and interactions in the jet. Methods. Correlation analysis of the extensive optical coverage by the ATOM telescope and nearly continuous gamma-ray coverage by the Fermi Large Area Telescope is combined with broadband, time-dependent modeling of the SED incorporating supplemental information from radio and X-ray observations of this blazar. Results. We analyse in detail four bright phases at optical-GeV energies. These flares of PKS 1424-418 show high correlation between these energy ranges, with the exception of one large optical flare that coincides with relatively low gamma-ray activity. Although the optical/gamma-ray behaviour of PKS 1424-418 shows variety, the multiwavelength modeling indicates that these differences can largely be explained by changes in the flux and energy spectrum of the electrons in the jet that are radiating. We find that for all flares the SED is adequately represented by a leptonic model that includes inverse Compton emission from external radiation fields with similar parameters. Conclusions. Detailed studies of individual blazars like PKS 1424-418 during periods of enhanced activity in different wavebands are helping us identify underlying patterns in the physical parameters in this class of AGN.
description: accepted for publication in A&A
The problem of images: A view from the brain-body
Creators: name: Gallese, Vittorio
Publisher: name: Phenomenology and Mind
Year: 2018

description: Why do humans create images and what are their features that make them special? How are image-making and the uses of images related? What is the purpose of images? The “problem of images” is addressed through the lens of contemporary neuroscience, arguing why and how neuroscience can investigate our relationship with art and aesthetics, framing this empirical approach as “experimental aesthetics.” Recent discoveries are presented that changed our ideas about perception, action, and cognition and the relationship among them, allowing a new look—complementary to the humanistic approach—at the problem of images. A new model of perception and cognition is proposed, called embodied simulation, which reveals the constitutive relationship between brain-body and the reception of human creative expressions.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Delineation of a contiguous gene syndrome with multiple exostoses, enlarged parietal foramina, craniofacial dysostosis, and mental retardation, caused by deletions in the short arm of chromosome 11.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: A contiguous gene syndrome due to deletions of the proximal short arm of chromosome 11 is described in eight patients belonging to four families. The main clinical features are multiple exostoses, enlarged parietal foramina, craniofacial dysostosis, and mental retardation. The patients have cytogenetic and/or molecular deletions of chromosome 11p11-p13. These deletions are located between the centromere and D11S914 in a region of approximately 20cM. The present study confirms the presence of a multiple exostoses gene on chromosome 11p. Furthermore, it suggests that the gene for isolated foramina parietalie permagna and genes associated with craniofacial dysostosis and mental retardation reside in the same chromosomal region.
Enactive Aesthetics and Neuroaesthetics
Creators: name: Fingerhut, Joerg
Publisher: name: Phenomenology and Mind
Year: 2018

description: In this paper, I review recent enactive approaches to art and aesthetic experience. Radical enactivists (Hutto, 2015) claim that our engagement with art is extensive, in the sense that it is non-contentful and artifact-including. Gallagher (2011) defends an embodied-enactive account of the specific kind of affordances artworks provide. For Noë (2015) art is a reorganizational practice. Each of these accounts claims that empirical (neuro)aesthetics is incapable of capturing the art-related engagement they want to highlight. While I agree on the relational and enactive nature of the mind and see the presented theories as important contributions to our understanding of art and aesthetics, I will argue that their dismissal of empirical aesthetics is misguided on several counts. A more qualified look can reveal relevant empirical research for claims enactive theorists should be interested in. Their criticism is either too general regarding the empirical methods employed or based on philosophical claims that themselves can be subjected to empirical scrutiny.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Conceptual semantics as grounded in personal experience
Creators: name: Conca, Francesca
name: Tettamanti, Marco
Publisher: name: Phenomenology and Mind
Year: 2018

description: Semantic memory for an object encompasses multi-modal knowledge gained through personal experience over the lifetime, and coded in grounded sensory-motor brain systems, independently of the level of subjective awareness. Linguistic access to semantic memories in verbal format relies on the functional coupling between perisylvian language regions and the grounded brain systems implied by our lifetime experience with the concept’s referents. Linguistic structure exerts modulatory influences on this functional coupling, as in the case of sentential negation, which reduces the interactions between perisylvian language regions and the grounded brain systems.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: We have identified 79 mutations in BRCA1 in a set of 643 Dutch and 23 Belgian hereditary breast and ovarian cancer families collected either for research or for clinical diagnostic purposes. Twenty-eight distinct mutations have been observed, 18 of them not previously reported and 12 of them occurring more than once. Most conspicuously, a 2804delAA mutation has been found 19 times and has never been reported outside the Netherlands. A common haplotype spanning > or = 375 kb could be identified for each of the nine examined recurrent mutations, indicating the presence of multiple BRCA1 founder mutations in the Dutch population. The 2804delAA mutation has been estimated to have originated approximately 32 generations ago. No specific breast or ovarian cancer phenotype could be assigned to any of the common mutations, and the ovarian cancer incidence among 18 families with the 2804delAA mutation was heterogeneous.
Art made for pictures
Creators: name: Kulvicki, John
name: Nanay, Bence
Publisher: name: Phenomenology and Mind
Year: 2018

description: Over the last fifteen years, communication has become pictorial in a manner that it never was before. Billions of people have smart phones that enable them to take, edit, and share pictures easily whenever they choose to do so. This has created expressive niches within which new activities, with their own norms, continue to develop. Ready availability of these pictorial modes of communication, we claim, not only constitutes a change in the range of our communicative practices, but also changes the world about which we communicate. Increasingly, we are making a world that’s worth depicting, using the tools we now possess. This paper will unpack one example of this phenomenon, trompe l’oeil street art. More and more of this seems to be produced with the intention that it is seen primarily in pictures. It makes sense that anything someone makes, and wants to be seen, would be made with decent photography potential in mind. You want photos to be able to, as they say, do justice to your work no matter what kind of visual work you make. In these cases, however, the pictures of the work are reliably more interesting than the pieces seen in the flesh.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
High-Energy Damping by Particle-Hole Excitations in the Spin-Wave Spectrum of Iron-Based Superconductors
Creators: name: Leong, Zhidong
name: Lee, Wei-Cheng
name: Lv, Weicheng
name: Phillips, Philip
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using a degenerate double-exchange model, we investigate the spin excitation spectra of iron pnictides. The model consists of local spin moments on each Fe site, as well as itinerant electrons from the degenerate $d_{xz}$ and $d_{yz}$ orbitals. The local moments interact with each other through antiferromagnetic $J_{1}$-$J_{2}$ Heisenberg interactions, and they couple to the itinerant electrons through a ferromagnetic Hund coupling. We employ the fermionic spinon representation for the local moments and perform a generalized random-phase approximation calculation on both spinons and itinerant electrons. We find that in the $\left(π,0\right)$ magnetically-ordered state, the spin-wave excitation at $\left(π,π\right)$ is pushed to a higher energy due to the presence of itinerant electrons, which is consistent with a previous study using the Holstein-Primakoff transformation. In the paramagnetic state, the particle-hole continuum keeps the collective spin excitation near $\left(π,π\right)$ at a higher energy even without any $C_{4}$ symmetry breaking. The implications for recent high temperature neutron scattering measurements will be discussed.
description: 7 pages, 5 figures
Heritability of Longitudinal Changes in Coronary-Heart-Disease Risk Factors in Women Twins
Creators: name: King, Mary-Claire
name: Newman, Beth
name: Austin, Melissa A.
name: Edwards, Karen
name: Mayer-Davis, Elizabeth J.
name: Friedlander, Yechiel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Numerous studies have demonstrated genetic influences on levels of coronary heart disease (CHD) risk factors, but there also may be genetic effects on the intraindividual variation in these risk factors over time. Changes in risk factors are likely to reflect genetic-environmental interactions and may have important implications for understanding CHD risk. The present study examines the heritability of changes in CHD risk factors, using data from the two examinations by the Kaiser Permanente Women Twins Study, performed a decade apart. The sample consisted of 348 pairs of women twins who participated in both examinations, including 203 MZ pairs and 145 DZ pairs. Average ages at the two examinations were 41 and 51 years, respectively. By means of three different statistical analytic approaches, moderate heritability estimates were demonstrated for changes in LDL cholesterol (h2 = .25-.36) and in HDL cholesterol (h2 = .23-.58), some of which were statistically significant. Although small to moderate heritability estimates were found for systolic blood pressure (.18-.37; P < .05 for some estimates), no genetic influence on changes in diastolic blood pressure was detected. Based on longitudinal twin data in women, this study demonstrates a genetic influence on changes in both lipoprotein risk factors and systolic blood pressure over a decade. In addition to environmental factors, which clearly are operating, the effect of various "variability genes" may be acting independently of the genetic influences on the absolute levels of these risk factors. Both mapping the gene(s) underlying intraindividual variations in these CHD risk factors and understanding their function(s) could lead to targeted intervention strategies to reduce CHD risk among genetically susceptible individuals.
Supplementary document for Monocular Kilometer-Scale Passive Ranging by Point-Spread Function Engineering - 6036580.pdf
Creators: name: Opatovski, Nadav
name: Xiao, Dafei
name: Harari, Gal
name: Shechtman, Yoav
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: subject: 20599 Optical Physics not elsewhere classified
subject: FOS: Physical sciences
subject: 111302 Optical Technology
subject: FOS: Clinical medicine

description: Supplemental document
The Nature of Pictorial Representations
Creators: name: Ferretti, Gabriele
Publisher: name: Phenomenology and Mind
Year: 2018

description: A crucial question in the study of picture perception asks about whether, when perceiving an object in a picture, we see only the depicted scene or, rather, we simultaneously see both the depicted scene and the surface. Two different views have fueled the debate since a long time. According to Wollheim, we see both the depicted scene and the picture’s surface simultaneously. Call this the ‘simultaneous account of picture perception’ (SA). SA is in contrast with Gombrich’s view that, during picture perception, we do not simultaneously see both the depicted scene and the surface, but we alternate between these two visual states. Call this the ‘non-simultaneous account of picture perception’ (NA). The debate between these two positions still persists in the contemporary literature on picture perception. In this paper, I first analyze the notion of vision SA and NA are committed to. Then, by discussing empirical evidence from vision science, I offer an argument that supports SA.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Twofold pictorial experience, propositional imagining and recognitional concepts: a critique of Walton’s visual make-believe
Creators: name: Arienti, Marco
Publisher: name: Phenomenology and Mind
Year: 2018

description: Kendall Walton has defined pictorial experience as a visual game of make-believe, which consists in imagining our actual seeing the representational prop to be a fictional face to face seeing the represented subject. To maintain a twofold awareness of these two visual aspects while avoiding a phenomenal clash between them, Walton needs to characterise visual make-believe as involving a propositional imagining. Unfortunately, the strategy does not seem to be successful. Whether propositional imagination is taken as a simple descriptive report or as conceptually penetrating our perception, Walton’s account is not able to secure the visual and the twofold character of pictorial recognition.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
Identification of common cystic fibrosis mutations in African-Americans with cystic fibrosis increases the detection rate to 75%.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Cystic fibrosis (CF)--an autosomal recessive disorder caused by mutations in CF transmembrane conductance regulator (CFTR) and characterized by abnormal chloride conduction across epithelial membranes, leading to chronic lung and exocrine pancreatic disease--is less common in African-Americans than in Caucasians. No large-scale studies of mutation identification and screening in African-American CF patients have been reported, to date. In this study, the entire coding and flanking intronic sequence of the CFTR gene was analyzed by denaturing gradient-gel electrophoresis and sequencing in an index group of 82 African-American CF chromosomes to identify mutations. One novel mutation, 3120+1G-->A, occurred with a frequency of 12.3% and was also detected in a native African patient. To establish frequencies, an additional group of 66 African-American CF chromosomes were screened for mutations identified in two or more African-American patients. Screening for 16 "common Caucasian" mutations identified 52% of CF alleles in African-Americans, while screening for 8 "common African" mutations accounted for an additional 23%. The combined detection rate of 75% was comparable to the sensitivity of mutation analysis in Caucasian CF patients. These results indicate that African-Americans have their own set of "common" CF mutations that originate from the native African population. Inclusion of these "common" mutations substantially improves CF mutation detection rates in African-Americans.
Candidate-Gene Studies of the Atherogenic Lipoprotein Phenotype: A Sib-Pair Linkage Analysis of DZ Women Twins
Creators: name: Newman, Beth
name: Austin, Melissa A.
name: Krauss, Ronald M.
name: Day, Ian N.M.
name: Humphries, Steve E.
name: Haddad, Lema
name: Edwards, Karen L.
name: Luong, Le-Ahn
name: Talmud, Philippa J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: There is a growing body of evidence supporting the roles of small, dense LDL and plasma triglyceride (TG), both features of the atherogenic lipoprotein phenotype, as risk factors for coronary heart disease. Although family studies and twin studies have demonstrated genetic influences on these risk factors, the specific genes involved remain to be determined definitively. The purpose of this study was to investigate genetic linkage between LDL size, TG, and related atherogenic lipoproteins and candidate genes known to be involved in lipid metabolism. The linkage analysis was based on a sample of 126 DZ women twin pairs, which avoids the potentially confounding effects of both age and gender, by use of a quantitative sib-pair linkage-analysis approach. Eight candidate genes were examined, including those for microsomal TG-transfer protein (MTP), hepatic lipase, hormone-sensitive lipase, apolipoprotein (apo) B, apo CIII, apo E, insulin receptor, and LDL receptor. The analysis suggested genetic linkage between markers for the apo B gene and LDL size, plasma levels of TG, of HDL cholesterol, and of apo B, all features of the atherogenic lipoprotein phenotype. Furthermore, evidence for linkage was maintained when the analysis was limited to women with a major LDL-subclass diameter >255 A, indicating that the apo B gene may influence LDL heterogeneity in the intermediate-to-large size range. In addition, linkage was found between the MTP gene and TG, among all the women. These findings add to the growing evidence for genetic influences on the atherogenic lipoprotein phenotype and its role in genetic susceptibility to atherosclerosis.
From Amplification to Gene in Thyroid Cancer: A High-Resolution Mapped Bacterial-Artificial-Chromosome Resource for Cancer Chromosome Aberrations Guides Gene Discovery after Comparative Genome Hybridization
Creators: name: Gonsky, R.
name: Knauf, J.A.
name: Chissoe, S.
name: Chen, X.-N.
name: Wang, M.
name: Fagin, J.A.
name: Lai, E.H.
name: Korenberg, J.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Chromosome rearrangements associated with neoplasms provide a rich resource for definition of the pathways of tumorigenesis. The power of comparative genome hybridization (CGH) to identify novel genes depends on the existence of suitable markers, which are lacking throughout most of the genome. We now report a general approach that translates CGH data into higher-resolution genomic-clone data that are then used to define the genes located in aneuploid regions. We used CGH to study 33 thyroid-tumor DNAs and two tumor-cell-line DNAs. The results revealed amplifications of chromosome band 2p21, with less-intense amplification on 2p13, 19q13.1, and 1p36 and with least-intense amplification on 1p34, 1q42, 5q31, 5q33-34, 9q32-34, and 14q32. To define the 2p21 region amplified, a dense array of 373 FISH-mapped chromosome 2 bacterial artificial chromosomes (BACs) was constructed, and 87 of these were hybridized to a tumor-cell line. Four BACs carried genomic DNA that was amplified in these cells. The maximum amplified region was narrowed to 3-6 Mb by multicolor FISH with the flanking BACs, and the minimum amplicon size was defined by a contig of 420 kb. Sequence analysis of the amplified BAC 1D9 revealed a fragment of the gene, encoding protein kinase C epsilon (PKCepsilon), that was then shown to be amplified and rearranged in tumor cells. In summary, CGH combined with a dense mapped resource of BACs and large-scale sequencing has led directly to the definition of PKCepsilon as a previously unmapped candidate gene involved in thyroid tumorigenesis.
LA RETORICA DEL PRIMORDIALISMO NEL DISCORSO NAZIONALISTA DI SUZUKI TAKAO E WATANABE SHŌICHI. ANALISI DI TRE SAGGI DI NIHONJINRON
Creators: name: VITALI, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: After fifty years since the boom of the Theories on Japanese culture (Nihonbunkaron) and in conjunction with the rise of Japan as a cultural superpower in the world, the official ideology of the establishment still keeps alive the stereotypes, clich�s and myths connected to the particularistic paradigm of ?Japanese nation? which was popular since the postwar period among Japanese intelligentsia especially in the form of the amatorial essay. Far from being weakened, the Nihonjinron nationalist discourse persists and proliferates through theories, opinions, discussions dealing with Japaneseness in the form of essays, articles, academic seminars, public discussions. Re-interpreting the primordialist perspective in the field of Nationalism Studies as a category of social practice (Coakley 2017), it is especially the belief in the primordiality of Japanese nation that is recently re-assessed with renewed strength by some ideologized and influential intellectuals as Suzuki Takao and Watanabe Sh?ichi. Echoing the philosophical ideas of German organicism on the nation embodied by Herder and Fichte, the textual and rhetorical analysis of Suzuki?s (2016, 2017) and Watanabe?s (2008) essays offers an interesting tool to bring on the surface the ideological mechanisms underlying Nihonjinron and its ideological core, primordialism.
On the NP-completeness of the Hartree-Fock method for translationally invariant systems
Creators: name: Whitfield, James D.
name: Zimborás, Zoltán
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The self-consistent field method utilized for solving the Hartree-Fock (HF) problem and the closely related Kohn-Sham problem, is typically thought of as one of the cheapest methods available to quantum chemists. This intuition has been developed from the numerous applications of the self-consistent field method to a large variety of molecular systems. However, as characterized by its worst-case behavior, the HF problem is NP-complete. In this work, we map out boundaries of the NP-completeness by investigating restricted instances of HF. We have constructed two new NP-complete variants of the problem. The first is a set of Hamiltonians whose translationally invariant Hartree-Fock solutions are trivial, but whose broken symmetry solutions are NP-complete. Second, we demonstrate how to embed instances of spin glasses into translationally invariant Hartree-Fock instances and provide a numerical example. These findings are the first steps towards understanding in which cases the self-consistent field method is computationally feasible and when it is not.
description: 6 pages
Occupational history associates with ALS survival and onset segment
Creators: name: Goutman, Stephen A.
name: Boss, Jonathan
name: Godwin, Christopher
name: Mukherjee, Bhramar
name: Feldman, Eva L.
name: Batterman, Stuart A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: To identify associations between occupational settings and self-reported occupational exposures on amyotrophic lateral sclerosis (ALS) survival and phenotypes. All patients seen in the University of Michigan Pranger ALS Clinic were invited to complete an exposure assessment querying past occupations and exposures. Standard occupational classification (SOC) codes for each job and the severity of various exposure types were derived. Cox proportional hazards models associated all-cause mortality with occupational settings and the self-reported exposures after adjusting for sex, diagnosis age, revised El Escorial criteria, onset segment, revised ALS Functional Rating Scale (ALSFRS-R), and time from symptom onset to diagnosis. Multinomial logistic regression models with three categories, adjusted for age, assessed the association between occupational settings and exposures to onset segment. Among the 378 ALS participants (median age, 64.7 years; 54.4% male), poorer survival was associated with work in SOC code “Production Occupations” and marginally with work in “Military Occupation”; poor survival associated with self-reported occupational pesticide exposure in adjusted models. Among onset segments: cervical onset was associated with ALS participants having ever worked in “Buildings and Grounds Cleaning and Maintenance Occupations,” “Construction and Extraction Occupations,” and “Production Occupations”; bulbar onset with self-reported occupational exposure to radiation; and cervical onset with exposure to particulate matter, volatile organic compounds, metals, combustion and diesel exhaust, electromagnetic radiation, and radiation. Occupational settings and self-reported exposures influence ALS survival and onset segment. Further studies are needed to explore and understand these relationships, most advantageously using prospective cohorts and detailed ALS registries.
Visually-based Knowingly Illusory Presence and Picture Display
Creators: name: Voltolini, Alberto
Publisher: name: Phenomenology and Mind
Year: 2018

description: The aim of this paper is twofold. First, I want to show how picture perception is specifically presentational, hence specifically perceptual, by suitably reinterpreting Richard Wollheim’s conception of seeing-in. Picture perception is such for it only ascribes the presence of the picture’s subject in its content, but not in its mode, for the subject is visually known not to be there: thus, it amounts to a knowingly illusory perceptual experience of such a presence. Second, I want to show how this presentational specificity does not prevent the picture itself from being properly presentational of the properties that are ascribed, within its perception, to its subject: the design properties of the picture’s vehicle present the perceivable properties ascribed to the picture’s subject just as the sensory features of a standard perceptual experience present the perceivable properties of its object.
description: Phenomenology and Mind, No 14 (2018): Perception and Aesthetic Experience
MOLECULAR MODELING OF EBOLA VIRUS INHIBITORS
Creators: name: DAPIAGGI, FEDERICO
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: In this PhD thesis computational methods have been employed in order to study different biologically relevant systems. In the first part of the thesis two Ebola virus proteins were studied, namely Viral Protein 24 (VP24) and Viral Protein 35 (VP35), responsible for the inhibition of the immune response . After a brief theoretical introduction to the main computational methods employed in the thesis, a study of VP35 in complex with small organic molecules is presented. These compounds are able to inhibit the interaction between VP35 and viral nucleoprotein. This study confirms the experimental findings highlighting new important key interactions between the protein the inhibitors. Moreover, an Essential Dynamics analysis points out an interesting collective motion of the apo-form that is hindered by the presence of the ligands. Afterwards, the protein-protein interaction VP24-Karyopherin (KPNA) is studied. An atomistic analysis of the interactions at the interface leads to the design of a nonapeptide with VP24 binding capability. The peptide is derived from a KPNA subsequence and could potentially inhibit the VP24-KPNA interaction. Subsequently an analysis on the pockets present on VP24 surface in different solvents is performed. Once the most promising pocket has been located, a virtual screening on a subset of ZINC database is carried out, leading to the identification of few classes of molecules potentially able to bind VP24. Finally the effect of the osmolytes on VP24 protein structure is studied, pointing out how osmoprotectants and urea have opposite effects on the protein, the former stabilizing the folded state and the latter shifting the equilibrium to the denatured state. In the second part of the manuscript the study of the interaction of an antimicrobial peptide with a lipid membrane is presented. This work was carried out in the University of Groningen under the supervision of Prof. Siewert Jan Marrink in order to deepen the Coarse Grain method.
A Variational Approach to Enhanced Sampling and Free Energy Calculations
Creators: name: Valsson, Omar
name: Parrinello, Michele
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The ability of widely used sampling methods, such as molecular dynamics or Monte Carlo, to explore complex free energy landscapes is severely hampered by the presence of kinetic bottlenecks. A large number of solutions have been proposed to alleviate this problem. Many are based on the introduction of a bias potential which is a function of a small number of collective variable. However constructing such a bias is not simple. Here we introduce a functional of the bias potential and an associated variational principle. The bias that minimizes the functional relates in a simple way to the free energy surface. This variational principle can be turned into a practical, efficient and flexible sampling method. A number of numerical examples are presented which include the determination of a three dimensional free energy surface. We argue that, beside being numerically advantageous, our variational approach provides a convenient standpoint for looking with novel eyes at the sampling problem.
description: 4 pages, 2 figures