cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Trichomanes cristatum Kaulf., Enum. Fil.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes cristatum

description: Trichomanes cristatum Kaulf., Enum. Fil. 265. 1824.
 Range: —Andes from Venezuela to Bolivia (LP, SC); central and eastern Brazil to eastern Paraguay and northeastern Argentina.
 Ecology: —Locally moderately common; terrestrial, rarely epiphytic, in humid forests, sometimes in swampy forests, places subjected to inundation, or even floating in swamp communities; to 2400 m.
 Notes: — Trichomanes crispum L., from southern Mexico and Antilles to northern South America (Colombia to Guianas, Ecuador, and northern Brazil), has been claimed to occur in Bolivia, but we have seen no unambiguous material. Rhizomes of T. crispum are short, erect, the leaves clustered; involucres are flared or only slightly bilobed, not subtended by protruding lateral veins and laminar tissue (or only slightly so). Involucres of T. cristatum are usually subtended by protruding lateral veins and laminar tissue.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 220, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Conformal Standard Model with an extended scalar sector
Creators: name: Latosinski, Adam
name: Lewandowski, Adrian
name: Meissner, Krzysztof A.
name: Nicolai, Hermann
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present an extended version of the Conformal Standard Model (characterized by the absence of any new intermediate scales between the electroweak scale and the Planck scale) with an enlarged scalar sector coupling to right-chiral neutrinos. The scalar potential and the Yukawa couplings involving only right-chiral neutrinos are invariant under a new global symmetry SU(3)$_N$ that complements the standard U(1)$_{B-L}$ symmetry, and is broken explicitly only by the Yukawa interaction, of order $10^{-6}$, coupling right-chiral neutrinos and the electroweak lepton doublets. We point out four main advantages of this enlargement, namely: (1) the economy of the (non-supersymmetric) Standard Model, and thus its observational success, is preserved; (2) thanks to the enlarged scalar sector the RG improved one-loop effective potential is everywhere positive with a stable global minimum, thereby avoiding the notorious instability of the Standard Model vacuum; (3) the pseudo-Goldstone bosons resulting from spontaneous breaking of the SU(3)$_N$ symmetry are natural Dark Matter candidates with calculable small masses and couplings; and (4) the Majorana Yukawa coupling matrix acquires a form naturally adapted to leptogenesis. The model is made perturbatively consistent up to the Planck scale by imposing the vanishing of quadratic divergences at the Planck scale (`softly broken conformal symmetry'). Observable consequences of the model occur mainly via the mixing of the new scalars and the standard model Higgs boson.
description: version accepted for publication in the JHEP, 41 pages, 1 figure
Trichomanes delicatum Bosch, Ned. Kruidk. Arch.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes delicatum

description: Trichomanes delicatum Bosch, Ned. Kruidk. Arch. 5: 145. 1861.
 Range: —Andes from Venezuela to Bolivia (CO, LP).
 Ecology: —Rare; epiphytic in humid forests; 500–2000 m.
 Notes: —All other Bolivian species of subg. Trichomanes lack hairs with dark, bulbous basal cells, although the basal cells may be slightly swollen.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 220, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer
Creators: name: Zhou, Chunxiao
name: Sun, Wenchuan
name: Sun, Li
name: Bae-Jump, Victoria L.
name: Clark, Leslie H.
name: Yin, Yajie
name: Gilliam, Timothy P.
name: Pan, Tommy
name: Madugu, Esther
name: Tran, Arthur-Quan
name: Sullivan, Stephanie A.
name: Guo, Hui
name: Zhang, Lu
name: Han, Jianjun
name: Jones, Hannah M.
name: Kilgore, Joshua
name: Jackson, Amanda L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Cancer cell metabolism is required to support the biosynthetic demands of cell growth and cell division, and to maintain reduction oxidaton (redox) homeostasis. This study was designed to test the effects of glucose and glutamine on ovarian cancer cell growth and explore the inter-relationship between glycolysis and glutaminolysis. The SKOV3, IGROV-1 and Hey ovarian cancer cell lines were assayed for glucose, pyruvate and glutamine dependence by analyzing cytotoxicity, cell cycle progression, apoptosis and ATP production. As determined by MTT assay, glucose stimulated cell growth while the combination of glucose, glutamine and pyruvate resulted in the greatest stimulation of cell proliferation. Furthermore, 2-deoxy-glucose (2-DG) and 3-bromopyruvate (3-BP) induced apoptosis, caused G1 phase cell cycle arrest and reduced glycolytic activity. Moreover, 2-DG in combination with a low dose of aminooxyacetate (AOA) synergistically increased the sensitivity to 2-DG in the inhibition of cell growth in the ovarian cancer cell lines. These studies suggest that dual inhibition of glycolysis and glutaminolysis may be a promising therapeutic strategy for the treatment of ovarian cancer.
The equidistribution of Elliptic Dedekind sums and generalized Selberg-Kloosterman sums
Creators: name: Klinger-Logan, Kim
name: Wong, Tian An
Publisher: name: arXiv
Year: 2024
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We show that the values of elliptic Dedekind sums, after normalization, are equidistributed mod 1. The key ingredient is a non-trivial bound on generalized Selberg-Kloosterman sums for discrete subgroups of $\PSL_2(\mathbb C)$ using Poincaré series.
description: 14 pages
MPEC 2023-T153 : DAILY ORBIT UPDATE (2023 October 11)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Annotating Ecological Data for Discovery and Reuse
Creators: name: Smith, Colin
name: O'Brien, Margaret
name: Kyle, Zollo-Venecek
Publisher: name: Zenodo
Year: 2022

description: Semantic annotation of LTER data will improve the precision and recall of EDI repository searches. To accomplish this, we envision an incremental process beginning with a foundational layer of semantic metadata for all data packages using the LTER controlled vocabulary as a starting point. This information may then be used to facilitate the organization of thematic working groups to identify concepts requiring annotations of greater complexity. In this workshop we will focus on forming the semantic base layer across all LTER data by tagging data packages with terms from the LTER Controlled Vocabulary (LTER-CV), which will be leveraged as a map to equivalent representations in the Environment Ontology (ENVO). Our goals for this workshop are: 1.) annotate LTER data packages with terms from the LTER-CV where gaps exist; 2.) identify and propose any terms that are missing from the LTER-CV. This workshop will result in an LTER/ENVO knowledge graph to facilitate more complex annotations in the future and to serve as an experimental space to inform the effectiveness of semantic annotation strategies. 2/3 of this workshop will be devoted to hands-on activities. Everyone is welcome. Bring your laptop.
Single-field $α$-attractors
Creators: name: Linde, Andrei
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I describe a simple class of $α$-attractors, generalizing the single-field GL model of inflation in supergravity. The new class of models is defined for $0
description: 3 pages
Trichomanes hostmannianum Kunze, Bot. Zeitung (Berlin
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes hostmannianum

description: Trichomanes hostmannianum (Klotzsch) Kunze, Bot. Zeitung (Berlin) 5: 352. 1847.
 Range: — Suriname to Colombia and south to central Brazil and Bolivia (BE, PA, SC).
 Ecology: —Locally fairly common; terrestrial, usually along ravines and in regularly flooded areas, sometimes periodically growing completely submerged, in humid forests; to 800 m.
 Notes: —Differs from Trichomanes pinnatum by lacking false cross-veins between the true veins, marginal veins lacking or faint and discontinuous, pinna margins commonly obtusely serrate. This species also has shorter leaves (to 30 cm vs. to 70 cm long) with smaller pinnae (to 6 × 1 cm vs. to 15 × 2 cm) and typically has dark or greenish black, opaque blades (vs. pale green, translucent blades).
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 221, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor
Creators: name: Zhang, Jinfang
name: Zhuang, Ming
name: Takada, Mamoru
name: Zurlo, Giada
name: Inuzuka, Hiroyuki
name: Zhang, Jing
name: Zhang, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: EglN2 contributes to ERα-positive breast tumorigenesis by acting as an estrogen-inducible gene. However, the detailed molecular mechanism(s) underlying the post-transcriptional regulation of EglN2 and its potential role in Triple Negative Breast Cancer (TNBC) remains largely unclear. By using C3Tag transgenic mice and tumor-derived C3Tag cell line, here we report that EglN2 contributes to TNBC tumor progression and genetic knockout of EglN2 improves C3Tag mice survival from tumor progression. Mechanistically, we further show that FBW7, an E3 ligase complex component that is frequently downregulated in TNBC, negatively regulates EglN2 protein stability. As such, depletion of FBW7 in breast cell lines leads to upregulation of EglN2 and other canonical FBW7 substrates. Conversely, FBW7 overexpression leads to EglN2 downregulation in a GSK3β-dependent manner. Furthermore, we identified some potential serine or threonine residues on the C-terminal of EglN2 that may mediate its binding and potential regulation by FBW7. Together, our study reveals that EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to TNBC.
Charge transport in molecular junctions: From tunneling to hopping with the probe technique
Creators: name: Kilgour, Michael
name: Segal, Dvira
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate that a simple phenomenological approach can be used to simulate electronic conduction in molecular wires under thermal effects induced by the surrounding environment. This "Landauer-Büttiker's probe technique" can properly replicate different transport mechanisms: phase coherent nonresonant tunneling, ballistic behavior, and hopping conduction, to provide results consistent with experiments. Specifically, our simulations with the probe method recover the following central characteristics of charge transfer in molecular wires: (i) The electrical conductance of short wires falls off exponentially with molecular length, a manifestation of the tunneling (superexchange) mechanism. Hopping dynamics overtakes superexchange in long wires demonstrating an ohmic-like behavior. (ii) In off-resonance situations, weak dephasing effects facilitate charge transfer. Under large dephasing the electrical conductance is suppressed. (iii) At high enough temperatures, $k_BT/ε_B>1/25$, with $ε_B$ as the molecular-barrier height, the current is enhanced by a thermal activation (Arrhenius) factor. However, this enhancement takes place for both coherent and incoherent electrons and it does not readily indicate the underlying mechanism. (iv) At finite-bias, dephasing effects impede conduction in resonant situations. We further show that memory (non-Markovian) effects can be implemented within the Landauer-Büttiker's probe technique to model the interaction of electrons with a structured environment. Finally, we examine experimental results of electron transfer in conjugated molecular wires and show that our computational approach can reasonably reproduce reported values to provide mechanistic information.
Supplementary documentation for SAEON's field instrument data collected at the Jonkershoek 11B station
Creators: name: South African Environmental Observation Network (SAEON) Fynbos Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Jonkershoek
Meteorological
Tipping bucket rain gauge
Rainfall
air temperature

description: This package contains supporting information for the meteorological data collected at Jonkershoek's 11B station, as part of the South African Environmental Observation Network's monitoring projects.
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer
Creators: name: Marayati, Raoud
name: Moffitt, Richard
name: Yeh, Jen Jen
name: Anderson, Marybeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence of metastasis and an overall poor prognosis. Previous work in a genetically engineered mouse model of PDAC showed glucose metabolism to be important for maintaining tumor growth. Multiple glycolytic enzymes, including hexokinase 2 (HK2), were upregulated in primary PDAC patient tumors, supporting a role for glycolysis in promoting human disease. HK2 was most highly expressed in PDAC metastases, suggesting a link between HK2 and aggressive tumor biology. In support of this we found HK2 expression to be associated with shorter overall survival in PDAC patients undergoing curative surgery. Transient and stable knockdown of HK2 in primary PDAC cell lines decreased lactate production, anchorage independent growth (AIG) and invasion through a reconstituted matrix. Conversely, stable overexpression of HK2 increased lactate production, cell proliferation, AIG and invasion. Pharmacologic inhibition of lactate production reduced the HK2-driven increase in invasion while addition of extracellular lactate enhanced invasion, together providing a link between glycolytic activity and metastatic potential. Stable knockdown of HK2 decreased primary tumor growth in cell line xenografts and decreased incidence of lung metastasis after tail vein injection. Gene expression analysis of tumors with decreased HK2 expression showed alterations in VEGF-A signaling, a pathway important for angiogenesis and metastasis, consistent with a requirement of HK2 in promoting metastasis. Overall our data provides strong evidence for the role of HK2 in promoting PDAC disease progression, suggesting that direct inhibition of HK2 may be a promising approach in the clinic.
Independence of Optical Absorption on Auger Ionization in Single-Walled Carbon Nanotubes Revealed by Ultrafast e-h Photodoping
Creators: name: Anderson, Mitchell D.
name: Beattie, Meghan N.
name: Alexander-Webber, Jack A.
name: Nicholas, Robin J.
name: Fraser, James M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Auger-ionized carriers in a one-dimensional semiconductor are predicted to result in a strong band-gap renormalization. Isolated single-walled carbon nanotubes (SWCNT) under high-intensity laser irradiation exhibit strong nonlinear photoluminescence (PL) due to exciton-exciton annihilation (EEA). The presence of exciton disassociation during the rapid Auger-ionization caused by EEA would lead to a strong nonlinear absorption. By simultaneously measuring SWCNT PL and optical absorption of isolated SWCNT clusters in the PL saturation regime, we give evidence that Auger-ionized excitons do not disassociate but remain bound.
description: 12 pages, 5 figures
Trichomanes lucens Sw., Prodr.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes lucens

description: Trichomanes lucens Sw., Prodr. 136. 1788.
 Range: — Jamaica; Costa Rica; southeastern and northern Venezuela to Bolivia (CO, LP); southeastern Brazil.
 Ecology: —Uncommon to moderately common; sometimes in wet rocky crevices, on Sphagnum or clay banks, in humid forests, also in shrubby secondary habitats; (1100–) 1900–3800 m.
 Notes: —Superficially similar to some species of Hymenophyllum, e.g., H. verecundum. Blades pendent or sometimes stiffly erect in parts of the range; this variation may indicate that the species is a complex.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 221, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice
Creators: name: Malloy, Kim M.
name: Lee, Douglas
name: Zhong, Yan
name: Han, Jianjun
name: Dickens, Hallum K.
name: Makowski, Liza
name: Huh, Gene
name: Zhang, Lu
name: Guo, Hui
name: Wysham, Weiya Z.
name: Zhou, Chunxiao
name: Bae-Jump, Victoria L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Obesity is a significant risk factor for ovarian cancer (OC) and associated with worse outcomes for this disease. We assessed the anti-tumorigenic effects of metformin in human OC cell lines and a genetically engineered mouse model of high grade serous OC under obese and lean conditions. Metformin potently inhibited growth in a dose-dependent manner in all four human OC cell lines through AMPK/mTOR pathways. Treatment with metformin resulted in G1 arrest, induction of apoptosis, reduction of invasion and decreased hTERT expression. In the K18-gT121+/-; p53fl/fl; Brca1fl/fl (KpB) mouse model, metformin inhibited tumor growth in both lean and obese mice. However, in the obese mice, metformin decreased tumor growth by 60%, whereas tumor growth was only decreased by 32% in the lean mice (p=0.003) compared to vehicle-treated mice. The ovarian tumors from obese mice had evidence of impaired mitochondrial complex 2 function and energy supplied by omega fatty acid oxidation rather than glycolysis as compared to lean mice, as assessed by metabolomic profiling. The improved efficacy of metformin in obesity corresponded with inhibition of mitochondrial complex 1 and fatty acid oxidation, and stimulation of glycolysis in only the OCs of obese versus lean mice. In conclusion, metformin had anti-tumorigenic effects in OC cell lines and the KpB OC pre-clinical mouse model, with increased efficacy in obese versus lean mice. Detected metabolic changes may underlie why ovarian tumors in obese mice have heightened susceptibility to metformin.
Supplementary documentation for SAEON's field instrument data collected at the Cathedral Peak Spectral probe - VI station
Creators: name: South African Environmental Observation Network (SAEON) Grasslands-Forests-Wetlands Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Cathedral Peak
Micro meteorological
Spectral probe
water quality

description: This package contains supporting information for the micro meteorological data collected at Cathedral Peak's Spectral probe - VI station, as part of the South African Environmental Observation Network's monitoring projects.
Generalised integrable $λ$- and $η$-deformations and their relation
Creators: name: Sfetsos, Konstantinos
name: Siampos, Konstantinos
name: Thompson, Daniel C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We construct two-parameter families of integrable $λ$-deformations of two-dimensional field theories. These interpolate between a CFT (a WZW/gauged WZW model) and the non-Abelian T-dual of a principal chiral model on a group/symmetric coset space. In examples based on the $SU(2)$ WZW model and the $SU(2)/U(1)$ exact coset CFT, we show that these deformations are related to bi-Yang-Baxter generalisations of $η$-deformations via Poisson-Lie T-duality and analytic continuation. We illustrate the quantum behaviour of our models under RG flow. As a byproduct we demonstrate that the bi-Yang-Baxter $σ$-model for a general group is one-loop renormalisable.
description: 33 pages, Latex, v2: 35 pages, Latex, clarifying comments, v3: few minor changes, NPB version
Population dynamics of Erica porteri (Erica thomae) in Kogelberg, Buffestalberg, site 3418BD/5/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Population dynamics
Erica porteri
Erica thomae
Kogelberg
Buffestalberg

description: This is a scanned copy of a document on the population dynamics of Erica porteri (Erica thomae) in Kogelberg, Buffestalberg, site 3418BD/5/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Reducing global CO2 emissions with the technologies we have
Creators: name: Ward, Hauke
name: Radebach, Alexander
name: Vierhaus, Ingmar
name: Fügenschuh, Armin
name: Steckel, Jan Christoph
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 330 Wirtschaft
subject: GHG mitigation potential
subject: sectoral energy intensities
subject: technology transfer
subject: multi-regional input output data
subject: optimization
subject: multiple production inputs
subject: supply chain effects

description: The energy intensities of the various industrial sectors differ considerably across countries. This suggests a potential for emissions reductions through improved accessibility to efficient technologies. This paper estimates an upper-bound CO2 emission mitigation potential that could theoretically be achieved by improved access to efficient technologies in industrial sectors. We develop a linear optimization framework that facilitates the exchange of sectoral production technologies based on the World Input-Output Database (WIOD), assuming perfect substitutability of technologies and homogeneity within economic sectors, while ignoring barriers to technological adoption and price driven adjustments. We consider the full global supply chain network and multiple upstream production inputs in addition to energy demand. In contrast to existing literature our framework allows to consider supply chain effects of technology replacements. We use our model to calculate emission reduction potentials for varying levels of access to technology. If best practice technologies were made available globally, CO2 emissions could theoretically be reduced by more than 10 gigatons (Gt). In fact, even second-tier production technologies would create significant global reduction potentials. We decompose sectoral emission reductions to identify contributions by changes in energy intensity, supply chain effects and changes in carbon intensities. Excluding the latter, we find that considering supply chain effects increases total mitigation potentials by 14%. The largest CO2 emission reduction potentials are found for a small set of developing countries.
Probing (topological) Floquet states through DC transport
Creators: name: Fruchart, Michel
name: Delplace, Pierre
name: Weston, Joseph
name: Waintal, Xavier
name: Carpentier, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider the differential conductance of a periodically driven system connected to infinite electrodes. We focus on the situation where the dissipation occurs predominantly in these electrodes. Using analytical arguments and a detailed numerical study we relate the differential conductances of such a system in two and three terminal geometries to the spectrum of quasi-energies of the Floquet operator. Moreover these differential conductances are found to provide an accurate probe of the existence of gaps in this quasi-energy spectrum, being quantized when topological edge states occur within these gaps. Our analysis opens the perspective to describe the intermediate time dynamics of driven mesoscopic conductors as topological Floquet filters.
description: 8 pages, 6 figures, invited contribution to the special issue of Physica E on "Frontiers in quantum electronic transport" in memory of Markus Buttiker
p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B
Creators: name: Franklin, Derek A.
name: Zhang, Yanping
name: Itahana, Yoko
name: Deisenroth, Chad
name: Di, Jiehui
name: Tang, Juanjuan
name: Zheng, Junnian
name: Qian, Heya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The tumor suppressor p53 plays a pivotal role in numerous cellular responses as it regulates cell proliferation, metabolism, cellular growth, and autophagy. In order to identify novel p53 target genes, we utilized an unbiased microarray approach and identified Rap2B as a robust candidate, which belongs to the Ras-related GTP-binding protein superfamily and exhibits increased expression in various human cancers. We demonstrated that p53 increases the intracellular IP3 and Ca2+ levels and decreases the LC3 protein levels through its target gene Rap2B, suggesting that p53 can inhibit the autophagic response triggered by starvation via upregulation of the Rap2B-PLCε-IP3-Ca2+ pathway. As a confirmed target gene of p53, we believe that further investigating potential functions of Rap2B in autophagy and tumorigenesis will provide a novel strategy for cancer therapy.
Trichomanes pilosum Raddi, Opusc. Sci.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes pilosum

description: Trichomanes pilosum Raddi, Opusc. Sci. 3: 296. 1819.
 Range: — Bolivia (BE, CO, LP, SC); central and eastern Brazil to adjacent Paraguay, Uruguay, and Argentina.
 Ecology: —Very common; terrestrial and on rocks, rarely epiphytic, in humid forests, often in open habitats such as ridges, steep, rocky slopes, or in disturbed scrub; 200–2200 m.
 Notes: —Variable and perhaps hybridizing with Trichomanes cristatum. Differs from T. cristatum by its arched, deltate to lanceolate leaves 4–25 cm long. Sometimes small plants become fertile, and individuals growing on exposed sites are usually very small. Morton (1968) incorrectly surmised that T. pilosum was related to, and an earlier name for, T. martiusii C.Presl, a distinctive, lowland Amazonian species belonging to subsect. Lamellata (Prantl) C.V.Morton, with accessory wings abaxially on the veins, but Windisch (1992) contradicted this.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 221, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer
Creators: name: Curigliano, Giuseppe
name: Awada, Ahmad
name: Aftimos, Philippe
name: Locatelli, Marzia A.
name: Pegram, Mark D.
name: Jiang, Yuqiu
name: Shaik, M. Naveed
name: LoRusso, Patricia M.
name: Huang, Bo
name: Kern, Kenneth A.
name: Cesari, Rossano
name: Claire Dees,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The NOTCH signaling pathway may be involved in the survival of stem cell-like tumor-initiating cells and contribute to tumor growth. In this phase Ib, open-label, multicenter study ({"type":"clinical-trial","attrs":{"text":"NCT01876251","term_id":"NCT01876251"}}NCT01876251), we evaluated PF-03084014, a selective gamma-secretase inhibitor in patients with advanced triple-negative breast cancer.
Trichomanes pinnatum Hedw., Fil. Gen. Sp.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes pinnatum

description: Trichomanes pinnatum Hedw., Fil. Gen. Sp. t. 4, f. 1. 1799.
 Range: —Antilles; southern Mexico to Bolivia (BE, CO, LP, PA, SC) and Brazil.
 Ecology: —Very common; terrestrial, often on stream banks, rarely in rock crevices or epiphytic, in humid forests; to 1100 m.
 Notes: —Although the species is treated as having monomorphic leaves, the fertile ones are often somewhat larger and with longer petioles than the sterile ones. Blades have a flagelliform rachis with a proliferous tip and abundant false cross-veins between the true veins.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 221, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Towards By-Product Utilisation of Pea Hulls: Isolation and Quantification of Galacturonic Acid
Creators: name: Gutöhrlein, Friederike
name: Drusch, Stephan
name: Schalow, Sebastian
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 630 Landwirtschaft und verwandte Bereiche
subject: 640 Hauswirtschaft und Familie
subject: pea hulls
subject: galacturonic acid
subject: Saeman hydrolysis
subject: TFA
subject: EDTA
subject: cellulose
subject: polygalacturonase

description: In order to evaluate by-products from food processing as alternative raw materials for pectin extraction, their amount of galacturonic acid (GalA) has to be analysed as a marker for pectin content. In the present study, significant differences in GalA release using different digestion methods are shown for pea hulls, as an example of by-products with a high content of cellulose. Complete digestion of the fibre matrix was assumed for Saeman hydrolysis as a reference protocol. Significantly lower GalA release was achieved by a treatment with trifluoracetic acid (TFA). An alternative treatment with ethylenediaminetetraacetic acid (EDTA) at pH 11 followed by an enzymatic digestion at pH 4.5 using a combination of polygalacturonase (Vegazyme M) and cellulase (Celluclast 1.5L) resulted in a similar release of GalA compared to Seaman hydolysis. Pea hull samples, analysed by this alternative protocol, showed on average a GalA content of 11.2%. Therefore, pea hulls may serve as new raw material for pectin extraction.
Trichomanes plumosum Kunze, Linnaea
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes plumosum

description: Trichomanes plumosum Kunze, Linnaea 9: 104. 1834.
 Range: —Andes from Venezuela to Bolivia (BE, CO, LP), western Brazil.
 Ecology: —Very common; terrestrial and less commonly epiphytic, in humid forests; 700–2250 m.
 Notes: —Differs from very similar Trichomanes cristatum mainly by the different abaxial rachis hairs (the adaxial rachis hairs are similar in both species). Both species frequently grow side-by-side and may hybridize.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 221, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Parallel axis theorem for free-space electron wavefunctions
Creators: name: Greenshields, Colin R.
name: Franke-Arnold, Sonja
name: Stamps, Robert L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider the orbital angular momentum of a free electron vortex moving in a uniform magnetic field. We identify three contributions to this angular momentum: the canonical orbital angular momentum associated with the vortex, the angular momentum of the cyclotron orbit of the wavefunction, and a diamagnetic angular momentum. The cyclotron and diamagnetic angular momenta are found to be separable according to the parallel axis theorem. This means that rotations can occur with respect to two or more axes simultaneously, which can be observed with superpositions of vortex states.
An autonomous Kirchhoff-type equation with general nonlinearity in $\mathbb{R}^N$
Creators: name: Lu, Sheng-Sen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35J15, 35J60

description: We consider the following autonomous Kirchhoff-type equation \begin{equation*} -\left(a+b\int_{\mathbb{R}^N}|\nabla{u}|^2\right)Δu= f(u),~~~~u\in H^1(\mathbb{R}^N), \end{equation*} where $a\geq0,b>0$ are constants and $N\geq1$. Under general Berestycki-Lions type assumptions on the nonlinearity $f$, we establish the existence results of a ground state and multiple radial solutions for $N\geq2$, and obtain a nontrivial solution and its uniqueness, up to a translation and up to a sign, for $N=1$. The proofs are mainly based on a rescaling argument, which is specific for the autonomous case, and a new description of the critical values in association with the level sets argument.
description: 20 pages. Major changes and added references
Trichomanes vandenboschii P. G. Windisch, Bradea
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes vandenboschii

description: Trichomanes vandenboschii P.G.Windisch, Bradea 5: 58. 1988.
 Range: —Sandstone massifs and outcrops of southeastern Venezuela and northern Brazil, eastern Colombia, Ecuador, Peru, and Bolivia (LP).
 Ecology: —Rare, known in Bolivia from one collection; saxicolous, in shaded rock crevices, also on tree trunks and wet, boggy places, in humid forests; 1200 m.
 Notes: —Differs from Trichomanes cristatum by its smaller size and relatively broader leaves.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 222, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer
Creators: name: Bae-Jump, Victoria L.
name: Zhou, Chunxiao
name: Guo, Hui
name: Gilliam, Timothy P.
name: Jones, Hannah M.
name: Kilgore, Joshua
name: Sun, Wenchuan
name: Yin, Yajie
name: Fang, Ziwei
name: Jackson, Amanda L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Obesity and diabetes have been associated with increased risk and worse outcomes in ovarian cancer (OC). The biguanide metformin is used in the treatment of type 2 diabetes and is also believed to have anti-tumorigenic benefits. Metformin is highly hydrophilic and requires organic cation transporters (OCTs) for entry into human cells. Phenformin, another biguanide, was taken off the market due to an increased risk of lactic acidosis over metformin. However, phenformin is not reliant on transporters for cell entry; and thus, may have increased potency as both an anti-diabetic and anti-tumorigenic agent than metformin. Thus, our goal was to evaluate the effect of phenformin on established OC cell lines, primary cultures of human OC cells and in an orthotopic mouse model of high grade serous OC. In three OC cell lines, phenformin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, caused cellular stress, inhibited adhesion and invasion, and activation of AMPK and inhibition of the mTOR pathway. Phenformin also exerted anti-proliferative effects in seven primary cell cultures of human OC. Lastly, phenformin inhibited tumor growth in an orthotopic mouse model of serous OC, coincident with decreased Ki-67 staining and phosphorylated-S6 expression and increased expression of caspase 3 and phosphorylated-AMPK. Our findings demonstrate that phenformin has anti-tumorigenic effects in OC as previously demonstrated by metformin but it is yet to be determined if it is superior to metformin for the potential treatment of this disease.
Charged Einstein-aether black holes and Smarr formula
Creators: name: Ding, Chikun
name: Wang, Anzhong
name: Wang, Xinwen
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the framework of the Einstein-Maxwell-aether theory, we present two new classes of exact charged black hole solutions, which are asymptotically flat and possess the universal as well as Killing horizons. We also construct the Smarr formulas, and calculate the temperatures of the horizons, using the Smarr mass-area relation. We find that, in contrast to the neutral case, such obtained temperature is not proportional to its surface gravity at any of the two kinds of the horizons. Einstein-Maxwell-aether black holes with the cosmological constant and their topological cousins are also given.
description: revtex4, 3 figures. To appear in Phys. Rev. D. arXiv admin note: text overlap with arXiv:1202.4497 by other authors
Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death
Creators: name: Shiau, Jeng-Yuan
name: Lee, Kuo-Hsiung
name: Nakagawa-Goto, Kyoko
name: Shyur, Lie-Fen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Triple negative breast cancer (TNBC) is a highly metastatic cancer among the breast cancer subgroups. A thorny issue for clinical therapy of TNBC is lack of an efficient targeted therapeutic strategy. We previously created a novel sesquiterpene lactone analog (named DETD-35) derived from plant deoxyelephantopin (DET) which exhibits potent effects against human TNBC MDA-MB-231 tumor growth in a xenograft mouse model. Here we studied the mechanisms of both DET and DETD-35 against MDA-MB-231 cells. DETD-35 (3-fold decreased in IC50) exhibited better anti-TNBC cell activity than DET as observed through induction of reactive oxygen species production (within 2 h treatment) and damage to the ER structures, resulting in ER-derived cytoplasmic vacuolation and ubiquitinated protein accumulation in the treated cells. Intriguingly, the effects of both compounds were blockaded by pretreatment with ROS scavengers, N-acetylcysteine and reduced glutathione, and protein synthesis inhibitor, cycloheximide. Further, knockdown of MEK upstream regulator RAF1 and autophagosomal marker LC3, and co-treatment with JNK or ERK1/2 inhibitor resulted in the most significant attenuation of DETD-35-induced morphological and molecular or biochemical changes in cancer cells, while the inhibitory effect of DET was not influenced by MAPK inhibitor treatment. Therefore, DETD-35 exerted both ER stress-mediated paraptosis and apoptosis, which may explain its superior activity to DET against TNBC cells. Although the chemotherapeutic drug paclitaxel induced vacuole-like structures in MDA-MB-231 cells, no paraptotic cell death features were detected. This study provides a strategy for combating TNBC through sesquiterpene lactone analogs by induction of oxidative and ER stresses that cause paraptosis-like cell death.
Trichomanes vittaria Poir., Encycl.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Trichomanes
Trichomanes vittaria

description: Trichomanes vittaria DC. ex Poir., Encycl. 8: 65. 1808.
 Range: —Guianas and eastern Colombia to Amazonian Brazil and Bolivia (BE, PA).
 Ecology: —Rare, known in Bolivia from two collections; terrestrial or on fallen logs, in humid forests; to 200 m.
 Notes: —This is the only species of Trichomanes in the Neotropics with entire blades.
description: Published as part of Kessler, Michael & Smith, Alan R., 2017, Prodromus of a fern flora for Bolivia. X. Hymenophyllaceae, pp. 201-226 in Phytotaxa 328 (3) on page 222, DOI: 10.11646/phytotaxa.328.3.1, http://zenodo.org/record/13722868
Supplementary documentation for SAEON's field instrument data collected at the Jonkershoek Langrivier 500 fog station
Creators: name: South African Environmental Observation Network (SAEON) Fynbos Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Jonkershoek
Meteorological
Automatic Weather Station
Rainfall
fog
air temperature
relative humidity
wind speed
wind direction

description: This package contains supporting information for the meteorological data collected at Jonkershoek's Langrivier 500 fog station, as part of the South African Environmental Observation Network's monitoring projects.
Asymptotic H-Plateau Problem in Hyperbolic 3-space
Creators: name: Coskunuzer, Baris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 53A10

description: We show that if a Jordan curve C in the asymptotic sphere contains a smooth point, there is an embedded H-plane in H^3 asymptotic to C for any H in [0,1).
description: 13 pages, 1 figure
Against the Current in the Kingdom of God: Isaiah Berlin’s Value-Pluralism and the Teachings of Leo Tolstoy
Creators: name: Sweetser, True
Publisher: name: Stanford Digital Repository
Year: 2022
Subjects: subject: Berlin, Isaiah, 1909-1997
subject: Tolstoy, Leo, graf, 1828-1910
subject: Hegel, Georg Wilhelm Friedrich, 1770-1831
subject: Herder, Johann Gottfried, 1744-1803
subject: Vico, Giambattista, 1668-1744
subject: Voĭna i mir (Prokofiev, Sergey)
subject: Maistre, Joseph Marie, comte de, 1753-1821
subject: Enlightenment
subject: Counter-Enlightenment

description: Isaiah Berlin (1909-1997) opens one of his most famous essays, “The Hedgehog and the Fox” with a quote from the Greek poet Archilochus, “the fox knows many things, but the hedgehog knows one big thing.”   Even if this classification may be overly simplistic, “every classification throws light on something,” and this scale can be particularly useful when discussing the central subject of Berlin’s essay on hedgehogs and foxes: Leo Tolstoy (1828-1910).  Berlin posits that “Tolstoy is a fox who believed passionately in being a hedgehog,” meaning that, in his literature, Tolstoy paints pictures of life as complex, full of diversity and contradictions, and not adherent to any singular ideology or worldview.   Meanwhile, in his didactic writings, particularly on the subject of history, Tolstoy seeks to explain events with a monist view; thus, Berlin believes that Tolstoy is “in constant contradiction with himself.”  However, just as this classification of hedgehogs and foxes can provide insight into the nature of Tolstoy’s literary and philosophical writings, it can also be turned back upon Berlin to help one understand why Berlin may reach this conclusion about Tolstoy in the first place.  This paper argues that Berlin himself is actually in the same quagmire he accuses Tolstoy of being trapped in, as he is a fox who nevertheless has a central hedgehog idea.  Berlin is foxlike in rejecting the idea that a utopia can be created on earth according to one unitary set of scientific, historic, political, or even aesthetic values.   This approach leads Berlin to seek many varied answers to life’s problems, but in seeking these answers, he has become so obsessed with value-pluralism that it is the one big idea he continually returns to, even if the subject in question does not demand it.
Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors
Creators: name: Strum, Jay C.
name: Jordan, Jamie L.
name: Roberts, Patrick J.
name: Sorrentino, Jessica A.
name: Bisi, John E.
name: Darr, David D.
name: Tavares, Francis X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Inhibition of the p16INK4a/cyclin D/CDK4/6/RB pathway is an effective therapeutic strategy for the treatment of estrogen receptor positive (ER+) breast cancer. Although efficacious, current treatment regimens require a dosing holiday due to severe neutropenia potentially leading to an increased risk of infections, as well as tumor regrowth and emergence of drug resistance. Therefore, a next generation CDK4/6 inhibitor that can inhibit proliferation of CDK4/6-dependent tumors while minimizing neutropenia could reduce both the need for treatment holidays and the risk of inducing drug resistance.