cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
Creators: name: Huang, Qian
name: Xia, Jiajia
name: Wang, Lei
name: Wang, Xu
name: Ma, Xiaodong
name: Deng, Qipan
name: Lu, Yong
name: Kumar, Munish
name: Zhou, Zhiyuan
name: Li, Ling
name: Zeng, Zhaoyang
name: Young, Ken
name: Yi, Qing
name: Zhang, Mingzhi
name: Li, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S1. IDO1 was induced by IFN-γ. IDO1 was induced by IFN-γ. (A) IDO1 expression of A549 and DLD-1 stimulated by 1-300 ng/ml IFN-γ for 24 h. IDO1 expression was measured using flow cytometry. (B) IDO1 expression in DLD-1 cells treated with 30 ng/ml IFN-γ for 3-48h. (C) IDO1 expression curves plotted from data in (A) and (B). (PDF 368 kb)
The production of hate crime victim status: Discourses of normalisation and the experiences of LGBT community members
Creators: name: Haynes, Amanda
name: Schweppe, Jennifer
name: Garland, Jon
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 48
subject: Law and legal studies
classificationCode: 44
subject: Human society

description: This article identifies discourses which serve to ‘normalise’ experiences of anti-LGBT (Lesbian,  Gay, Bisexual and Transgender) violence and prevent harmed LGBT persons from accessing  the status of ‘hate crime victim’. The phenomenon of normalisation is established in research  addressing homophobic, biphobic and transphobic violence, where it is understood fundamentally  as the rendering unremarkable of violent manifestations of hate due to their ubiquity. This article  interrogates the dynamics of the normalisation process. Drawing on a Foucauldian approach, we  explore normalisation as a disciplinary practice, through which people who have experienced  anti-LGBT violence are denied access to the status of hate crime victim. Through discourse  analysis of focus group data, we identify obstacles to identification and self-identification as a  victim grounded in the experience and anticipation of judgement both within society and the  LGBT community. Discourses against which the claims of LGBT people are adjudicated (re) produce cultural myths about hate crime, about anti-LGBT violence and about victimhood. While  this article acknowledges that the value of identifying as a victim is not uncontested, it also  asserts that the practice of normalisation, in denying this status, impacts on access to justice
Roadside survey on alcohol and drug use among drivers in the Arctic county of Finnmark (Norway)
Creators: name: Jamt, Ragnhild E. G.
name: Gjerde, Hallvard
name: Normann, Per T.
name: Bogstrand, Stig T.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: The objective of this study was to determine the prevalence of alcohol and potentially impairing drugs among the general driving population in Finnmark and to compare the prevalence among Norwegian, Russian, and other foreign drivers by analyzing samples of oral fluid. Methods: In collaboration with local police, drivers were selected for a voluntary and anonymous study using a multistage cluster sampling procedure (selection of roads, time intervals, and drivers within each interval) from September 2014 to October 2015. Age, gender, citizenship, time, and geographical site were recorded. Samples of oral fluid were collected using the Quantisal device. The samples were analyzed for alcohol with an enzymatic method and for 12 illicit drugs and 16 medicinal drugs and some metabolites using ultra-high-performance liquid chromatography with tandem mass spectrometry detection. Results: A total of 3,228 drivers were asked to participate in the study. The refusal rate was 6.2%. Of the 3,027 participants in the study, 111 (3.7%) were Russian and 204 (6.7%) had citizenship other than Norwegian or Russian. The total prevalence of psychoactive substances was 4.3%. Alcohol was detected in 0.3%, psychoactive medicinal drugs in 2.5%, and illicit drugs in 1.6% of the samples. The most commonly found substances were the sleeping agent zopiclone (1.1%), tetrahydrocannabinol (THC; 1.1%), and the analgesic agent codeine (0.6%). Illicit drugs were detected significantly more often in samples from drivers of citizenship other than Norwegian or Russian. The prevalence of alcohol was somewhat higher among Russian drivers but not statistically significant. There were large differences between age groups and genders concerning illicit drugs and psychoactive medicinal drugs; illicit drugs were more frequently in samples from young male drivers, whereas psychoactive medicinal drugs were more frequently in samples from elderly female drivers. Conclusion: The total prevalence of alcohol and drugs among the general driving population in Finnmark was low and similar to previous Norwegian roadside surveys. Illicit drugs were detected significantly more often in samples from drivers with citizenship other than Russian and Norwegian and among young male drivers.
Additional file 2: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
Creators: name: Huang, Qian
name: Xia, Jiajia
name: Wang, Lei
name: Wang, Xu
name: Ma, Xiaodong
name: Deng, Qipan
name: Lu, Yong
name: Kumar, Munish
name: Zhou, Zhiyuan
name: Li, Ling
name: Zeng, Zhaoyang
name: Young, Ken
name: Yi, Qing
name: Zhang, Mingzhi
name: Li, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S2. IDO2 and TDO expression in relationship to survival of patients with colorectal cancer. (A) Overall survival of patients with colon cancer (n = 382) in the TCGA database. Patients were classified as having high or low IDO2 (left) or TDO (right) expression according the median level. (B) Survival in days according to IDO2 expression level of patients in Panel A. (PDF 266Â kb)
Additional file 3: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
Creators: name: Huang, Qian
name: Xia, Jiajia
name: Wang, Lei
name: Wang, Xu
name: Ma, Xiaodong
name: Deng, Qipan
name: Lu, Yong
name: Kumar, Munish
name: Zhou, Zhiyuan
name: Li, Ling
name: Zeng, Zhaoyang
name: Young, Ken
name: Yi, Qing
name: Zhang, Mingzhi
name: Li, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Figure S3. miRNAs are predicted to target the IDO1 3' UTR. (A) Schematic representation of the pmirGLO vector carrying two dual luciferase genes and the IDO1 3' UTR. (B and C) Dual luciferase assays from 293T cells (B) or Hela cells (C) transfected with miR-153 and the pmirGLO construct. (PDF 189Â kb)
Roadside survey on alcohol and drug use among drivers in the arctic county of finnmark (Norway)
Creators: name: Jamt, Ragnhild E. G.
name: Gjerde, Hallvard
name: Normann, Per T.
name: Bogstrand, Stig T.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To determine the prevalence of alcohol and potentially impairing drugs among the general driving population in Finnmark and to compare the prevalence among Norwegian, Russian and other foreign drivers by analyzing samples of oral fluid. Methods: In collaboration with local police, drivers were selected for a voluntary and anonymous study using a multistage cluster sampling procedure (selection of roads, time intervals, and drivers within each interval) from September 2014 to October 2015. Age, gender, citizenship, time and geographical site were recorded. Samples of oral fluid were collected using the Quantisal device. The samples were analyzed for alcohol with an enzymatic method and for 12 illicit drugs and 16 medicinal drugs and some metabolites using UPLC-MS/MS. Results: A total of 3228 drivers were asked to participate in the study. The refusal rate was 6.2 percent. Of the 3027 participants in the study 111 (3.7%) were Russian and 204 (6.7%) had citizenship other than Norwegian or Russian. The total prevalence of psychoactive substances was 4.3 percent. Alcohol was detected in 0.3 percent, psychoactive medicinal drugs in 2.5 percent and illicit drugs in 1.6 percent of the samples. The most commonly found substances were the sleeping agent zopiclone (1.1%), tetrahydrocannabinol (THC) (1.1%) and the analgesic agent codeine (0.6%). Illicit drugs were significantly more often detected in samples from drivers of citizenship other than Norwegian or Russian. The prevalence of alcohol was somewhat higher among Russian drivers, but not statistically significant. There were large differences between age groups and genders concerning illicit drugs and psychoactive medicinal drugs; illicit drugs were more frequently in samples from young male drivers, while psychoactive medicinal drugs were more frequently in samples from elderly female drivers. Conclusion: The total prevalence of alcohol and drugs among the general driving population in Finnmark was low and similar to previous Norwegian roadside surveys. Illicit drugs were significantly more often detected in samples from drivers with citizenship other than Russian and Norwegian, and among young, male drivers.
Roadside survey on alcohol and drug use among drivers in the arctic county of Finnmark (Norway)
Creators: name: Jamt, Ragnhild E. G.
name: Gjerde, Hallvard
name: Normann, Per T.
name: Bogstrand, Stig T.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To determine the prevalence of alcohol and potentially impairing drugs among the general driving population in Finnmark and to compare the prevalence among Norwegian, Russian and other foreign drivers by analyzing samples of oral fluid. Methods: In collaboration with local police, drivers were selected for a voluntary and anonymous study using a multistage cluster sampling procedure (selection of roads, time intervals, and drivers within each interval) from September 2014 to October 2015. Age, gender, citizenship, time and geographical site were recorded. Samples of oral fluid were collected using the Quantisal device. The samples were analyzed for alcohol with an enzymatic method and for 12 illicit drugs and 16 medicinal drugs and some metabolites using UPLC-MS/MS. Results: A total of 3228 drivers were asked to participate in the study. The refusal rate was 6.2 percent. Of the 3027 participants in the study 111 (3.7%) were Russian and 204 (6.7%) had citizenship other than Norwegian or Russian. The total prevalence of psychoactive substances was 4.3 percent. Alcohol was detected in 0.3 percent, psychoactive medicinal drugs in 2.5 percent and illicit drugs in 1.6 percent of the samples. The most commonly found substances were the sleeping agent zopiclone (1.1%), tetrahydrocannabinol (THC) (1.1%) and the analgesic agent codeine (0.6%). Illicit drugs were significantly more often detected in samples from drivers of citizenship other than Norwegian or Russian. The prevalence of alcohol was somewhat higher among Russian drivers, but not statistically significant. There were large differences between age groups and genders concerning illicit drugs and psychoactive medicinal drugs; illicit drugs were more frequently in samples from young male drivers, while psychoactive medicinal drugs were more frequently in samples from elderly female drivers. Conclusion: The total prevalence of alcohol and drugs among the general driving population in Finnmark was low and similar to previous Norwegian roadside surveys. Illicit drugs were significantly more often detected in samples from drivers with citizenship other than Russian and Norwegian, and among young, male drivers.
Additional file 4: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
Creators: name: Huang, Qian
name: Xia, Jiajia
name: Wang, Lei
name: Wang, Xu
name: Ma, Xiaodong
name: Deng, Qipan
name: Lu, Yong
name: Kumar, Munish
name: Zhou, Zhiyuan
name: Li, Ling
name: Zeng, Zhaoyang
name: Young, Ken
name: Yi, Qing
name: Zhang, Mingzhi
name: Li, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S4. IDO1 downregulation by miR-153 is inducer and time independence. (A and B) IDO1 expression in DLD-1 cells treated by Cp-G DNA or LPS was down-regulated by miR-153 as measured by flow cytometry (A) or by western blotting (B). DLD-1 cells were treated with LPS or cp-G DNA for 12 h. (C and D) The IDO1 protein (C) or mRNA (D) levels in DLD-1 and HCT-116 cells transfected with or without miR-153 before treated with LPS for 6 to 24 h. (PDF 309Â kb)
NOXs in Pulmonary Diseases: A Potential Therapeutic Avenue ?
Creators: name: Carnesecchi, Stéphanie
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/616.07

description: Pulmonary diseases including acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) affect millions of individuals, and are associated mostly with high mortality and even death. To date, there is no therapeutic option available to stop the progression of pulmonary diseases, making it a major scientific challenge and public health concern. Although the molecular and cellular mechanisms involved in lung pathogenesis are not fully elucidated, a wealth of evidence indicates that reactive oxygen species generated by NOX enzymes might be major actors in lung pathogenic processes. Indeed, NOX enzymes are expressed in different human and rodent lung cell types and contribute to the development of lung diseases in a broad range of animal models. In this context, targeting NOX enzymes might represent a novel strategy for a cure of lung diseases. In the current thesis, the knowledge relating to the cellular expression and the function of NOX enzymes in physiological and pathological situation will be summarized. In addition, the potential place of NOX inhibitors for the treatment of lung diseases will be addressed.
Additional file 5: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
Creators: name: Huang, Qian
name: Xia, Jiajia
name: Wang, Lei
name: Wang, Xu
name: Ma, Xiaodong
name: Deng, Qipan
name: Lu, Yong
name: Kumar, Munish
name: Zhou, Zhiyuan
name: Li, Ling
name: Zeng, Zhaoyang
name: Young, Ken
name: Yi, Qing
name: Zhang, Mingzhi
name: Li, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Figure S5. The activation of T cells exhibits no difference when co-cultured with tumor cells with or without miR-153. T cells were co-cultured in DLD-1+miR-153 (orange) or DLD-1+NC cells (green) for 24 hours. The expression of the designated T cell activation markers was measured by flow cytometry. (PDF 206Â kb)
Récupération après une lésion cérébrale : facteurs décisifs en rééducation
Creators: name: Leemann, Béatrice
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/616.8
Rééducation neurologique
Plasticité cérébrale
Accident vasculaire cérébral
Traumatisme cranio-cérébral

description: En se basant sur une revue de la littérature et sur l'expérience personnelle ce travail décrit les principaux facteurs modifiables dont il faut tenir compte pour soutenir la récupération après une lésion cérébrale vasculaire ou traumatique. Il comprend 2 chapitres principaux: 1) comment éviter, reconnaître et traiter les complications supplémentaires. 2) comment diminuer le déficit se basant sur ce que l'on sait de la plasticité cérébrale.
Isotopes to assess sustainability of overexploited groundwater in the Souss–Massa system (Morocco)
Creators: name: Hssaisoune, Mohammed
name: Lhoussaine Bouchaou
name: Baudelaire N’da
name: Malki, Mouna
name: Houria Abahous
name: Fryar, Alan E.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Groundwater depletion and changes in isotopic and chemical contents constitute the main indicators of overexploitation, recharge, and flow paths in the Souss–Massa aquifer. These indicators highlight processes concerning sustainability of water resources in the aquifer (e.g. surface/groundwater interaction, recharge processes, and marine intrusion). The spatial variation of stable and radioactive isotopic contents indicates a mixing of modern and old water within the system. Recent recharge was observed mainly along the Souss River (the major surface-water drainage in the study area) and in the irrigated areas. Mapping of chemical and isotopic variation shows that the area is affected by abstraction, irrigation water return, and the evolution of modern recharge in time and space. The processes, distribution, and timing of groundwater flow are influenced by short- and long-term effects; long-term recharge is dependent on climatic conditions. This study can be used to make informed decisions about water-resource allocation and alternative management practices.
Population structure reduces benefits from partner choice in mutualistic symbiosis - Supplementary Information
Creators: name: Akҫay, Erol
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Model details, mathematical analyses, and simulation results
Phytochemical composition and antioxidant activity of medicinal plants collected from the Tunisian flora
Creators: name: N. Neffati
name: Z. Aloui
name: H. Karoui
name: I. Guizani
name: M. Boussaid
name: Y. Zaouali
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Polyphenols, flavonoids and condensed tannins contents, as well as the antioxidant activity of the ethanolic and aqueous extracts obtained from aerial parts of 10 wild Tunisian plants, have been determined. Extracts showed appreciable levels of polyphenols and flavonoids, which reached 215.16 mg GAE g−1 DW in Lavandula stoechas ethanolic extract, and 49.12 mg RE g−1 DW in Thapsia garganica aqueous extract. The majority of tested extracts exhibited low total condensed tannins content, except for Rhus tripartitum and Periploca laevigata. The antioxidant activity tests showed great activity, especially for R. tripartitum and Lavandula multifida (IC50 = 5.16 and 5.1 μg mL−1, respectively). Canonical Correspondence Analysis revealed clear groupings of species according to the solvent used.
Preparation of a Low-cost and Eco-friendly Superabsorbent Composite Based on Wheat Bran and Laterite for Potential Application in Chinese Herbal Medicine Growth
Creators: name: Gao, Jiande
name: Liu, Jin
name: Peng, Hui
name: Wang, Yaya
name: Cheng, Sha
name: Lei, Ziqiang
Publisher: name: The Royal Society
Year: 2018

description: A low-cost and eco-friendly superabsorbent composite is prepared through the free-radical graft co-polymerization of wheat bran (WB), acrylic acid (AA) and laterite (LA) in an aqueous solution. Elemental map, scanning electron microscopy and Fourier transform infrared spectra revealed that the LA evenly distributed in the superabsorbent composite and wheat bran-g-poly(acrylic acid)/laterite (WB-g-PAA/LA) formed successfully. Thermogravimetric analysis confirmed that the WB-g-PAA/LA had high thermal stability. Furthermore, the properties of the WB-g-PAA/LA, such as swelling in saline solutions and degradation, are also assessed. The final WB-g-PAA/LA (5 wt%) superabsorbent composite attained an optimum water absorbency of 1425 g g−1 in distilled water and 72 g g−1 in 0.9 wt% NaCl solution. The water absorbency of WB-g-PAA/LA (10 wt%) is even greater than that of the WB-g-PAA. Moreover, the water-retention capacity of WB-g-PAA/LA (5 wt%) is high, and the water-retention process followed a zero-order reaction. The reaction rate constant is 8.2428 × 105 exp(−Ea/RT) and the apparent activation energy (Ea) is 35.11 kJ mol−1. Furthermore, WB-g-PAA/LA (5 wt%) may regulate the release of urea, indicating that the superabsorbent composite could provide a promising application as a urea fertilizer carrier. Additionally, it increased the germination and growth rates of Glycyrrhiza uralensis Fisch, suggesting it could influence the growth of Chinese herbal medicine.
Hydroponic method for ramie and removal of nitrogen and phosphorus from livestock wastewater
Creators: name: Gao, Gang
name: Xiong, Heping
name: Chen, Jikang
name: Chen, Kunmei
name: Chen, Ping
name: Yu, Chunming
name: Zhu, Aiguo
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: By using a hydroponic culture system, the terrestrial fiber crop ramie can growth optimally in aquatic environment and enhance exponentially quantities of high quality seedlings for subsequent field cultivation. In this study, the survival rate of ramie seedling was more than 97% when cultured using the novel hydroponic method. Further physiological analysis of the hydroponic ramie to different concentration of livestock wastewater demonstrated that all of these ramies can survival in livestock wastewater, but the 4 times diluted livestock wastewater (total N: 100.9 mg L−1, total P: 2.69 mg L−1) was more appropriate for ramie growth. The nutrients N and P in livestock wastewater were significantly decreased by the growth of ramie, and the removal efficiency of total N and total P in the 4 times diluted livestock wastewater achieved 78.1% and 43.1% respectively within 5 weeks. In conclusion, our studies highlight that the combination of ramie and the hydroponic technology resulted to be effective in the phytoremediation of livestock wastewater.
Research of pathogenic mutations in the human genome through the study of consanguineous families
Creators: name: Makrythanasis, Periklis
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/576.5

description: In this thesis I present my work towards the better understanding of recessive disorders in consanguineous families and the discovery of new genes responsible for autosomal recessive disorders. The introduction provides the background that made these studies possible and describes the progress that happened the last 15 years in our understanding of the human genome and the technological and analytical technologies and tools that have been developed that enabled the scientific community to devise new strategies for the identification of novel recessive genes. At the second part a selection of 6 papers is provided from my work in: i) the demonstration of the capacity of our method to identify pathogenic mutations and the further understanding of the burden these diseases represent for the populations that practice consanguinity, ii) the development of new bioinformatics tools necessary for the analysis of these families in order to take full advantage of the newest technologies and iii) specific examples of genes where we have identified a new gene for intellectual disability, identified a gene responsible for thrombocytopenia similar to a model organism and finally the identification of a novel phenotype of a gene, most probably due to a different pathogenetic mechanism. The last section provides some perspectives about the future of the research in the domain both from the aspect of genomics and consanguinity.
РЕСУРСЫ ЭЛЕКТРОННЫХ КОРПУСОВ В СОВРЕМЕННОЙ ЛЕКСИКОГРАФИИ
Creators: name: Абдиева, Камола
name: Хидирова, Г.Н.
Publisher: name: Zenodo
Year: 2024

description: В статье рассматриваются в современные разработки и использование корпусных словарей на базе информационных технологий. Также даны определение корпусной лингвистике, выделены общие критерии ее описания, дана дефиниция непосредственно самому объекту нашего исследования- лингвистическому корпусу.
ARTICLE ON CEMENT INDUSTRY.docx
Creators: name: Kyuom Saffi
Publisher: name: figshare
Year: 2017
Subjects: subject: 90403 Chemical Engineering Design
subject: FOS: Chemical engineering
subject: 49999 Earth Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 120201 Building Construction Management and Project Planning
subject: FOS: Civil engineering
subject: 100602 Input, Output and Data Devices
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 91201 Ceramics
subject: FOS: Materials engineering
subject: 90499 Chemical Engineering not elsewhere classified
subject: 91505 Heat and Mass Transfer Operations
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 39903 Industrial Chemistry
subject: FOS: Chemical sciences

description: My data is on cement industry.In my data i have mentioned suggestions necessary for establishing and running cement industry and also important factors that affect cement industry production.Very informative article for chemical engineer and mechanical engineer
Germination of grass species in soil affected by crude oil contamination
Creators: name: Zhu, Huisen
name: Gao, Yang
name: Li, Deying
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Many grass species exist in the oil exploration areas of North Dakota. The objective of this study was to evaluate seed germination of 65 grass species affected by crude oil. Germination of all species was reduced by crude oil, ranging from 4.3 to 100%. Twenty-eight species were tolerant, 29 moderately tolerant, 6 moderately sensitive, and 2 sensitive. Based on the tolerance levels, the following were used to further test the dose response to crude oil: strong creeping red fescue (Festuca rubra L. ssp. rubra), perennial ryegrass (Lolium perenne L.), orchardgrass (Dactylis glomerata L.), buffalograss [Buchloe dactyloides (Nutt.) Engelm.], little bluestem [Schizachyrium scoparium (Michx.) Nash], witchgrass (Panicum capillare L.), sand dropseed [Sporobolus cryptandrus (Torr.) Gray], Johnsongrass [Sorghum halepense (L.) Pers.], and smooth crabgrass [Digitaria ischaemum (Schreb.) Schreb. ex Muhl.]. The EC50 of germination and biomass was effective in ranking the 9 species. Buffalograss, sand dropseed, and orchardgrass were ranked as the most tolerant species with EC50 values of 0.1, > highest concentration tested, 0.05 m3 m−3 (P < 0.05), respectively. Smooth crabgrass and little bluestem were ranked as most sensitive with EC50 values of 0.03 and 0.04 m3 m−3 (P < 0.05), respectively. Buffalograss showed the lowest germination (10.4%) and biomass reduction (25%) (P < 0.05).
Supplementary Information from Fundamental limitations of network reconstruction from temporal data
Creators: name: Angulo, Marco Tulio
name: Moreno, Jaime A.
name: Gabor Lippner
name: Albert-László Barabási
name: Yang-Yu Liu
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Inferring properties of the interaction matrix that characterizes hownodes in a networked system directly interact with each other is a well-known network reconstruction problem. Despite a decade of extensive studies, network reconstruction remains an outstanding challenge. The fundamental limitations governing which properties of the interaction matrix (e.g. adjacency pattern, sign pattern or degree sequence) can be inferred from given temporal data of individual nodes remain unknown. Here, we rigorously derive necessary conditions to reconstruct any property of the interaction matrix. Counterintuitively, we find that reconstructing any property of the interaction matrix is generically as difficult as reconstructing the interaction matrix itself, requiring equally informative temporal data. Revealing these fundamental limitations sheds light on the design of better network reconstruction algorithms that offer practical improvements over existing methods.
Supplementary Material for: Expression Changes of Long Noncoding RNA in the Process of Endothelial Cell Activation
Creators: name: Zhou, M.
name: Ding, W.-J.
name: Chen, Y.-W.
name: Shen, F.
name: Zeng, J.-Y.
name: Wei, Y.-F.
name: Qu, C.
name: Xu, L.-M.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Endothelial cells have been shown to be in response to a variety of local and systemic stimuli, and are able to transition between quiescent and activated states. Endothelial cell activation is critical for the pathogenesis of various cardiovascular diseases. However, the expression changes of long non-coding RNAs (lncRNAs) are still unknown in the process of endothelial cell activation. Thus, this study was aimed to investigate expression changes of lncRNA before and after endothelial cell activation. Materials and Methods: In an experimental model of peripheral venous congestion, endothelial cells were activated and analyzed with Affymetrix HG-U133 plus2.0 microarray. We analyzed these microarray data and reannotated the microarray probes for lncRNA. Results: According to the definition of absolute fold change>2 and p value <0.05, 27 differentially expressed lncRNAs were identified and only 1 lncRNA transcript, ENST00000509256 was down-regualted. Co-expression network of lncRNA and mRNA were constructed to predict function of the dysregulated lncRNA. Gene set enrichment analyses suggested that these ENST00000509256 was associated with many important functions, such as cell-cell signaling and regulation of cell differentiation. Conclusion: Many lncRNAs are dysregulated upon endothelial cell activation and further experiments are needed to identify the potential biological functions of these lncRNAs.
Figure S1 from Gliding lizards use the position of the sun to enhance social display
Creators: name: Klomp, Danielle A.
name: Stuart-Fox, Devi
name: Indraneil Das
name: Ord, Terry J.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Top down view of lizard perch angles (90°, 330° and 240°) in relation to the position of the sun. From: Klomp, D. A., Stuart-Fox, D., Das, I. & Ord, T. J. 2017. Gliding lizards use the position of the sun to enhance social display. Biology Letters.
Electronic supplementary materials from Spatio-temporal environmental variation mediates geographical differences in phenotypic responses to ocean acidification
Creators: name: Gaitán-Espitia, Juan Diego
name: Villanueva, Paola A.
name: Lopez, Jorge
name: Torres, Rodrigo
name: Navarro, Jorge M.
name: Bacigalupe, Leonardo
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science
subject: Ecology

description: Legends included in the electronic supplementary materials
The positive impact of othering in voluntourism: The role of the relational other in becoming another self
Creators: name: McAllum, Kirstie
name: Zahra, Anne
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Despite initial enthusiasm about the potential of voluntourism to promote sustainable development and intercultural learning, recent critiques have focused on voluntourists’ tendency to reinforce status differences by “Othering” their hosts. This study expands the literature on Othering in international voluntourism contexts by examining how local community members who interacted with voluntourists interpreted the Self–Other relationship. Based on longitudinal focus group data from four host communities, the findings showed that the categories of “Self” and “Other” were not fixed but fluid, permeable, and dynamic. The study suggests that the Othering process can open up unexpected relational spaces and reconfigure community–voluntourist relationships.
Can Big Data Forecast North Korean Military Aggression?
Creators: name: Young Han (Andy) Kim
name: Hyoung-Goo Kang
name: Lee, Jong Kyu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Marine Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Can textual analysis improve statistical prediction of risky geopolitical events? North Korea is the greatest source of geopolitical risk for South Korea due to the former’s unpredictable and secretive military actions against the latter. We find that the tone of English language news articles published by non-South Korean news media, especially U.K. news media, has significant predictive power about North Korean military aggressions. The inclusion of language tone improves the predictive power of the empirical model by as much as 47%.
MOESM1 of CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading
Creators: name: Chu, Xin
name: Jin, Qunyan
name: Chen, Hui
name: Wood, G.
name: Petrick, Anthony
name: Strodel, William
name: Gabrielsen, Jon
name: Benotti, Peter
name: Mirshahi, Tooraj
name: Carey, David
name: Still, Christopher
name: DiStefano, Johanna
name: Gerhard, Glenn
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Table S1. Demographics and clinical characteristics of patients from whom samples were analyzed using Affymetrix Arrays. Table S2. Demographics and clinical characteristics of patients from whom samples were analyzed using the Human Inflammatory Cytokines and Receptors PCR Array. Table S3. Expression of genes in severe fibrosis relative to normal histology using the Human Inflammatory Cytokines and Receptors PCR Array. Table S4. Demographics and histological characteristics of patients from whom samples were analyzed using the CCL20 ELISA. Figure S1. Quantification of Oil Red O stained lipid-loaded HEPG2 cells. Figure S2. Quantification of Oil Red O stained lipid-loaded LX-2 cells. Figure S3. CCL20 protein levels in media of lipid-loaded LX-2 cells. Figure S4. CCL20 ELISA standard curve.
Additional file 1: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer
Creators: name: Lin, Ling-Yun
name: Yang, Li
name: Zeng, Qiang
name: Wang, Lin
name: Chen, Mao-Li
name: Zhao, Ze-Hang
name: Ye, Guo-Dong
name: Luo, Qi-Cong
name: Lv, Pei-Yu
name: Guo, Qi-Wei
name: Li, Bo-An
name: Cai, Jian-Chun
name: Cai, Wang-Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Table S1. Clinical characteristics of patients and healthy individuals of all sets. (PDF 176Â kb)
Additional file 1: of Differential networking meta-analysis of gastric cancer across Asian and American racial groups
Creators: name: Dai, Wentao
name: Li, Quanxue
name: Liu, Bing-Ya
name: Li, Yi-Xue
name: Li, Yuan-Yuan
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Molecular Biology
Biological Sciences not elsewhere classified

description: Supplementary Figure and legends. Figure S1. Quality assessment of our data set (GSE54129). Figure S2. Expression level distribution of genes in three datasets. Figure S3. The differential networking meta-analysis framework. Figure S4. The GIF expression in different patient groups based on Neoplasm Histologic Grade. (DOCX 1497Â kb)
Additional file 2: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer
Creators: name: Lin, Ling-Yun
name: Yang, Li
name: Zeng, Qiang
name: Wang, Lin
name: Chen, Mao-Li
name: Zhao, Ze-Hang
name: Ye, Guo-Dong
name: Luo, Qi-Cong
name: Lv, Pei-Yu
name: Guo, Qi-Wei
name: Li, Bo-An
name: Cai, Jian-Chun
name: Cai, Wang-Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Figure S1. Characterization and quantification of exosome levels and heatmap of the up-regulated exosomal lncRNAs and mRNAs identified in the screening. (A) Transmission electron microscopy (TEM) revealed the phenotype of exosomes isolated from stage I GC patient and healthy control plasma samples. Scale bar, 100 nm. (B) TEM revealed the phenotype of exosomes isolated from GCC and HPSEC culture media. Scale bar, 200 nm. (C and D) NanoSight particle tracking analysis of the size distributions and number of exosomes isolated from stage I GC patient and healthy control plasma samples (C) and isolated from GCC and HPSEC culture media (D). (E and F) Western blot showing the presence of specific exosome marker proteins (CD9 and CD63) and the absence of tubulin in exosomes derived from stage I GC patient and healthy control plasma samples (E) and derived from GCC and HPSEC culture media (F). (G) Heatmap of the 79 up-regulated exosomal lncRNAs and mRNAs between the plasma samples of stage I GC patients (n = 10) and healthy controls (n = 5). (H) Heatmap of the 285 up-regulated exosomal lncRNAs and mRNAs between GCC (n = 4) and HPSEC (n = 4) culture media. (PDF 395 kb)
The challenge of implementing less is more medicine in Switzerland
Creators: name: Kherad, Omar
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/618.97
Overuse
Low value care
Efficiency

description: "Less is more" in medicine is an invitation to recognize the potential risks of overuse of medical care that may result in harm rather than in better health. It is indeed necessary to eliminate unnecessary and costly practices by streamlining care without rationing. However, several barriers and challenges for the implementation of less is more medicine have been identified in Switzerland, where overuse is rooted in our culture and demanded by a society that requests certainty at almost any cost. Patients' high expectations, physician behavior, lack of monitoring and pernicious financial incentives have all indirect negative consequences for medical overuse. Multiple interventions and quality-measurement efforts are necessary to widely implement less is more recommendations. These include financial incentives, patient education, physician behavior change with data feedback, communication training and systems interventions. A quality-oriented approach can be an intellectual challenge but also a real opportunity to promote sustainable medicine.
Endosseous implant optimization:from implant surface modifications to bone regeneration
Creators: name: Durual, Stéphane
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/617.6
Titanium
Implant
Bone regeneration
Surface modification
Bone substitutes
3D-printing
Bioceramics
Titanium oxynitrides
Osteoblast.

description: Replacing one or several missing teeth, whether for reasons of pathology or trauma, has become very common. A system of artificial roots are inserted and integrated in the mandible or the maxilla to support fixed or removable restorations. The implant has to be mechanically stable, and integrated into the bone in order to mediate and distribute, as physiologically as possible, the biomechanical stresses applied to the system tooth-bone, a phenomenon called osseointegration. The success of a good osseointegration is multifactorial, including the materials properties (chemical, physical mechanical and structural), the implant design, the surgical techniques, the pathophysiological context and the bone health and quality. During our research, we focused on two particular issues: 1- The materials “ surface characteristics », and more specifically the surface chemistry of endosseous implants on which we applied various thin metallic coatings. 2- The « health and bone quality » by developping innovative materials for bone regeneration. We demonstrated that TiNxOy coatings may be applied to various metallic substrates to improve their osseointegration, allowing the use of materials more efficient mechanically, beyond their native biocompatibility. On the other hand, we also developed an innovative bone substitute by using 3D-printing processes. This material, structurally highly organized, may lead to an osseoconduction rate (i.e. the capacity for a structure to conduct bone cells migration and growth) that is largely superior to actual standards. This material is also resorbable, and may support the development of a mature bone tissue. These works open a broad range of perspectives both in the basic science and in the applied science, including, as for example, a better understanding of the molecular mechanisms of osseointegration, or the development of hybrid materials combining cells, bioceramics and hydrogels in a prevasscularized osseoconductive structure.
Role of systematic reviews in the identification and prevention of poor quality research and scientific misconduct: random reflections based on anaesthesiologic cases
Creators: name: Elia, Nadia
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/613
info:eu-repo/classification/ddc/617
systematic review
research misconduct
research malpractice

description: Research in clinical medicine often suffers from poor methodological quality and is sometimes based on fraudulent data, which may bias the conclusions of systematic reviews. This dissertation develops the idea that not all research malpractices and misconduct threaten the scientific knowledge, nor may they all bias the conclusions of systematic reviews to the same extent, but rather that the strict procedures applied during proper systematic reviewing actually should make systematic reviews robust to some common errors and misconduct. Moreover, well-performed systematic reviews could become part of the solution to the problem by providing clear research agendas and by providing important methodological information that may be used for future research. Furthermore, systematic reviewers may correct the published literature after having identified errors during critical appraisal of articles, and they may even play the role of whistle-blowers by identifying new, yet unrecognised, cases of misconducts.
Additional file 1: of Transcriptomic and metabolic flux analyses reveal shift of metabolic patterns during rice grain development
Creators: name: Shen, Fangzhou
name: Wu, Xueting
name: Shi, Luoxi
name: Zhang, Hang
name: Chen, Yangmin
name: Qi, Xiaoquan
name: Wang, Zhuo
name: Li, Xuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: The list of primary and secondary metabolic pathways in rice. (DOCX 13Â kb)