cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: A molecular relay race: sequential first-passage events to the terminal reaction centre in a cascade of diffusion controlled processes
Creators: name: Grebenkov, Denis
name: Metzler, Ralf
name: Oshanin, Gleb
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 520 Astronomie und zugeordnete Wissenschaften
subject: 530 Physik

description: We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles. The model studied here represents a typical reaction setting encountered in diverse molecular biology systems, in which, e.g. a signal transduction proceeds via a series of consecutive 'messengers': the first messenger has to find its respective immobile target site triggering a launch of the second messenger, the second messenger seeks its own target site and provokes a launch of the third messenger and so on, resembling a relay race in human competitions. For such a molecular relay race taking place in infinite one-, two- and three-dimensional systems, we find exact expressions for the probability density function of the time instant of the terminal reaction event, conditioned on preceding successful reaction events on an ordered array of target sites. The obtained expressions pertain to the most general conditions: number of intermediate stages and the corresponding diffusion coefficients, the sizes of the target sites, the distances between them, as well as their reactivities are arbitrary.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1159
IMPROVING NEONATAL PROCEDURAL PAIN MANAGEMEMT
Creators: name: Flowers, Lauren
Publisher: name: Zenodo
Year: 2015

description: Neonates experience repeated routine painful procedures during the course of hospitalization and often times this is done with no measure of pain relief. Although nurses are aware of hospital guidelines and policies and procedures for alleviating neonatal pain, adherence with documentation of pain assessments and reassessments remains low. In March, 2014, a neonatal pain audit was conducted to assess nurse’s compliance with neonatal pain management in a Maternal/Neonatal Unit in a large Southern California Magnet® hospital. Audit revealed a lack of documented neonatal pain scores and post pain assessments. To improve documentation of neonatal pain; collaboration with Information Technology (IT) Department was accomplished to integrate a computer based build using the electronic health system and nursing educational interventions. The computer integration build makes it difficult for nurses to fail to document pain assessment before and after painful procedures. An alert is built into the system to remind nurses to document a pain assessment at the start of painful procedures as well as post procedure/intervention. The procedural pain computer integration education involves use of IT-created pictorial representations of how to document from beginning to end. Planned evaluation includes assessment of workability, nurse’s knowledge of procedural pain management, and audits procedural pain management documentation.
Orchis pallens Linnaeus 1771
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis pallens

description: 19. O. pallens L,. , Mantissa Alt. 292(1771). Tubers subglobose or ovoid, more or less stipitate. Stem 15-35 cm, erect, with leaves in lower half and sheaths above, naked in the uppermost part. Leaves oblong or oblong-obovate, gradually narrowed towards the base. Spike ovoid or oblong, dense. Bracts lanceolate, 1 - veined, as long as or longer than ovary. Flowers pale yellow, with odour of Sambucus nigra. Outer perianth-segments 7-9 mm, ovate-oblong, obtuse, the 2 lateral deflexed, the median erect; inner perianth-segments obliquely oblong. Labellum 6-8 x 6-8 mm, suborbicular-rhombic, 3-lobed; lateral lobes orbicular, obtuse; middle lobe almost square, truncate or emarginate. Spur cylindrical, patent, slightly shorter than ovary. 2n = 40. C. & S. E. Europe, extending to the S. W. Alps and C. Appennini. Al Au Bu Cz Ga Ge Gr He Hu It Ju Po Rm Rs (K).
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
title: TRIPOD - A Treadmill Walking Dataset with IMU, Pressure-distribution and Photoelectric Data for Gait Analysis
Creators: name: Trautmann, Justin
name: Zhou, Lin
name: Brahms, Clemens Markus
name: Tunca, Can
name: Ersoy, Cem
name: Granacher, Urs
name: Arnrich, Bert
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten

description: Inertial measurement units (IMUs) enable easy to operate and low-cost data recording for gait analysis. When combined with treadmill walking, a large number of steps can be collected in a controlled environment without the need of a dedicated gait analysis laboratory. In order to evaluate existing and novel IMU-based gait analysis algorithms for treadmill walking, a reference dataset that includes IMU data as well as reliable ground truth measurements for multiple participants and walking speeds is needed. This article provides a reference dataset consisting of 15 healthy young adults who walked on a treadmill at three different speeds. Data were acquired using seven IMUs placed on the lower body, two different reference systems (Zebris FDMT-HQ and OptoGait), and two RGB cameras. Additionally, in order to validate an existing IMU-based gait analysis algorithm using the dataset, an adaptable modular data analysis pipeline was built. Our results show agreement between the pressure-sensitive Zebris and the photoelectric OptoGait system (r = 0.99), demonstrating the quality of our reference data. As a use case, the performance of an algorithm originally designed for overground walking was tested on treadmill data using the data pipeline. The accuracy of stride length and stride time estimations was comparable to that reported in other studies with overground data, indicating that the algorithm is equally applicable to treadmill data. The Python source code of the data pipeline is publicly available, and the dataset will be provided by the authors upon request, enabling future evaluations of IMU gait analysis algorithms without the need of recording new data.
description: Postprints der Universität Potsdam : Reihe der Digital Engineering Fakultät; pde006
title: Controls of outbursts of moraine-dammed lakes in the greater Himalayan region
Creators: name: Fischer, Melanie
name: Korup, Oliver
name: Veh, Georg
name: Walz, Ariane
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: Glacial lakes in the Hindu Kush–Karakoram–Himalayas–Nyainqentanglha (HKKHN) region have grown rapidly in number and area in past decades, and some dozens have drained in catastrophic glacial lake outburst floods (GLOFs). Estimating regional susceptibility of glacial lakes has largely relied on qualitative assessments by experts, thus motivating a more systematic and quantitative appraisal. Before the backdrop of current climate-change projections and the potential of elevation-dependent warming, an objective and regionally consistent assessment is urgently needed. We use an inventory of 3390 moraine-dammed lakes and their documented outburst history in the past four decades to test whether elevation, lake area and its rate of change, glacier-mass balance, and monsoonality are useful inputs to a probabilistic classification model. We implement these candidate predictors in four Bayesian multi-level logistic regression models to estimate the posterior susceptibility to GLOFs. We find that mostly larger lakes have been more prone to GLOFs in the past four decades regardless of the elevation band in which they occurred. We also find that including the regional average glacier-mass balance improves the model classification. In contrast, changes in lake area and monsoonality play ambiguous roles. Our study provides first quantitative evidence that GLOF susceptibility in the HKKHN scales with lake area, though less so with its dynamics. Our probabilistic prognoses offer improvement compared to a random classification based on average GLOF frequency. Yet they also reveal some major uncertainties that have remained largely unquantified previously and that challenge the applicability of single models. Ensembles of multiple models could be a viable alternative for more accurately classifying the susceptibility of moraine-dammed lakes to GLOFs.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1160
title: A Conserved Hydrophobic Moiety and Helix-Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4
Creators: name: Evers †, Andreas
name: Wolff, Martin
name: Gast, Klaus
name: Kurz, Michael
name: Pfeiffer-Marek, Stefania
name: Schüler, Anja
name: Seckler, Robert
name: Thalhammer, Anja
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie

description: Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix–helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1161
Bayesian modelling of DNA secondary structure kinetics : revisiting path space approximations and posterior inference in exponentially large state spaces
Creators: name: Lovrod, Jordan
Publisher: name: University of British Columbia
Year: 2023

description: Nucleic acid strands, which react by forming and breaking Watson-Crick base pairs, can be designed to form complex nanoscale structures or devices. Controlling such systems requires accurate predictions of the reaction rate and folding pathways of the interacting strands. These kinetic properties can be modelled using continuous-time Markov chains (CTMCs), whose states and transitions correspond to secondary structures and elementary base pair changes, respectively. The transient dynamics of a CTMC are determined by a kinetic model, which assigns transition rates to pairs of states. The rate of a reaction can be estimated using its CTMC's mean first passage time (MFPT), which can be computed exactly by solving a linear system, or approximated via Monte Carlo simulation. However, both approaches may be computationally infeasible for rare event reactions in larger systems. This limitation can be addressed by constructing truncated CTMCs, which only include a small subset of states and transitions, selected either manually or through simulation. In recent work, posterior inference in an Arrhenius-type kinetic model was performed using a fixed set of manually truncated CTMCs and a small experimental dataset of DNA reaction rates. We extend this Bayesian approach, using a larger dataset of 1105 reactions, a new prior model that is directly motivated by the physical meaning of the parameters and is compatible with experimental measurements of elementary rates, and larger truncated state spaces, constructed stochastically using the recently introduced pathway elaboration method. Despite a significantly higher computational cost, we find that the larger state spaces do not necessarily lead to more accurate rate predictions than the small, manually designed state spaces. For posterior approximation, we apply the standard random walk Metropolis algorithm and the gradient-based no-u-turn sampler. Our posterior approximations, which are often multimodal, recover an expected correlation structure among the kinetic parameters. However, we also uncover severe numerical instability in the MPFT computations. Due to numerous design limitations in the legacy software, a significant refactoring effort was required to implement the above extensions, resulting also in improvements in performance and reproducibility.
title: Spatio-temporal soil moisture retrieval at the catchment scale using a dense network of cosmic-ray neutron sensors
Creators: name: Heistermann, Maik
name: Francke, Till
name: Schrön, Martin
name: Oswald, Sascha E.
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: Cosmic-ray neutron sensing (CRNS) is a powerful technique for retrieving representative estimates of soil water content at a horizontal scale of hectometres (the “field scale”) and depths of tens of centimetres (“the root zone”). This study demonstrates the potential of the CRNS technique to obtain spatio-temporal patterns of soil moisture beyond the integrated volume from isolated CRNS footprints. We use data from an observational campaign carried out between May and July 2019 that featured a dense network of more than 20 neutron detectors with partly overlapping footprints in an area that exhibits pronounced soil moisture gradients within one square kilometre. The present study is the first to combine these observations in order to represent the heterogeneity of soil water content at the sub-footprint scale as well as between the CRNS stations. First, we apply a state-of-the-art procedure to correct the observed neutron count rates for static effects (heterogeneity in space, e.g. soil organic matter) and dynamic effects (heterogeneity in time, e.g. barometric pressure). Based on the homogenized neutron data, we investigate the robustness of a calibration approach that uses a single calibration parameter across all CRNS stations. Finally, we benchmark two different interpolation techniques for obtaining spatio-temporal representations of soil moisture: first, ordinary Kriging with a fixed range; second, spatial interpolation complemented by geophysical inversion (“constrained interpolation”). To that end, we optimize the parameters of a geostatistical interpolation model so that the error in the forward-simulated neutron count rates is minimized, and suggest a heuristic forward operator to make the optimization problem computationally feasible. Comparison with independent measurements from a cluster of soil moisture sensors (SoilNet) shows that the constrained interpolation approach is superior for representing horizontal soil moisture gradients at the hectometre scale. The study demonstrates how a CRNS network can be used to generate coherent, consistent, and continuous soil moisture patterns that could be used to validate hydrological models or remote sensing products.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1162
Orchis provincialis Balbis 1806
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis provincialis

description: 20. O. provincialis Balbis, Mém. Acad. Sei. (Turin) 1805-1808: 20 (1806) . Tubers subglobose or ovoid. Stem 15-35 cm, erect, with 2-5 leaves at the base and sheaths above. Leaves lanceolate or oblong-lanceolate. Spike cylindrical. Bracts lanceolate, 1 - to 3-veined, at least as long as ovary. Flowers pale yellow, or white with deep yellow labellum, with slight odour. Outer perianth-segments 9-11 mm, ovate-oblong, obtuse, the 2 lateral deflexed, the median erect; inner smaller, obliquely oblong. Labellum suborbicular, 3-lobed; lateral lobes rounded; middle lobe small, orbicular-truncate, scarcely longer than the lateral. Spur cylindrical, patent, as long as or longer than ovary. 2n = 42. 5. Europe. A 1 Bu Co Cr Ga Gr He Hs It Ju Rs (K) Sa Si.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
title: Efficient Hazard Assessment For Pluvial Floods In Urban Environments: A Benchmarking Case Study For The City Of Berlin, Germany
Creators: name: Seleem, Omar
name: Heistermann, Maik
name: Bronstert, Axel
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: The presence of impermeable surfaces in urban areas hinders natural drainage and directs the surface runoff to storm drainage systems with finite capacity, which makes these areas prone to pluvial flooding. The occurrence of pluvial flooding depends on the existence of minimal areas for surface runoff generation and concentration. Detailed hydrologic and hydrodynamic simulations are computationally expensive and require intensive resources. This study compared and evaluated the performance of two simplified methods to identify urban pluvial flood-prone areas, namely the fill–spill–merge (FSM) method and the topographic wetness index (TWI) method and used the TELEMAC-2D hydrodynamic numerical model for benchmarking and validation. The FSM method uses common GIS operations to identify flood-prone depressions from a high-resolution digital elevation model (DEM). The TWI method employs the maximum likelihood method (MLE) to probabilistically calibrate a TWI threshold (τ) based on the inundation maps from a 2D hydrodynamic model for a given spatial window (W) within the urban area. We found that the FSM method clearly outperforms the TWI method both conceptually and effectively in terms of model performance.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1163
title: Plume-induced subduction initiation
title: Single-slab or multi-slab subduction?
titleType: Subtitle
Creators: name: Baes, Marzieh
name: Sobolev, Stephan
name: Gerya, Taras
name: Brune, Sascha
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: Initiation of subduction following the impingement of a hot buoyant mantle plume is one of the few scenarios that allow breaking the lithosphere and recycling a stagnant lid without requiring any preexisting weak zones. Here, we investigate factors controlling the number and shape of retreating subducting slabs formed by plume-lithosphere interaction. Using 3-D thermomechanical models we show that the deformation regime, which defines formation of single-slab or multi-slab subduction, depends on several parameters such as age of oceanic lithosphere, thickness of the crust and large-scale lithospheric extension rate. Our model results indicate that on present-day Earth multi-slab plume-induced subduction is initiated only if the oceanic lithosphere is relatively young (<30-40 Myr, but >10 Myr), and the crust has a typical thickness of 8 km. In turn, development of single-slab subduction is facilitated by older lithosphere and pre-imposed extensional stresses. In early Earth, plume-lithosphere interaction could have led to formation of either episodic short-lived circular subduction when the oceanic lithosphere was young or to multi-slab subduction when the lithosphere was old.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1167
Orchis provincialis subsp. provincialis Balbis 1806
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis provincialis
Provincialis

description: (a) Subsp.provincialis: Leaves usually with dark spots. Spike dense, with 5-20 flowers. Labellum 8-12x8-12 mm. Almost throughout the range of the species.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
title: The Kentucky Re-Entry Universal Payload System (KRUPS)
title: Orbital Flight
titleType: Subtitle
Creators: name: Nichols, James
Publisher: name: University of Kentucky Libraries
Year: 2021
Subjects: subject: FOS: Mechanical engineering

description: Due to the uniqueness of atmospheric entry environments, ground facilities cannot accurately replicate re-entry conditions. Consequently, scientists primarily rely on numerical models to predict these conditions and inform Thermal Protection System (TPS) designs. These models often lack flight validation, which is necessary for increasing their fidelity. Thus, there is a substantial need to obtain such data to advance modeling capabilities.

The Kentucky Re-entry Universal Payload System (KRUPS) is an adaptable test-bed for scientific experimentation with initial application to TPS. This vehicle was designed at the University of Kentucky to serve as an inexpensive means of obtaining validation data to enhance models developed at the university. KRUPS will be conducting its first orbital mission in July, 2021 on board Cygnus NG-15, a resupply vehicle serving the International Space Station. This mission, dubbed Kentucky Re-Entry Probe Experiment (KREPE) will provide the first set of relevant flight data for comparison and validation of computational results for the vehicle.
description: © James Tyler Nichols 2020
title: Projected changes in Rhine River flood seasonality under global warming
Creators: name: Rottler, Erwin
name: Bronstert, Axel
name: Bürger, Gerd
name: Rakovec, Oldrich
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: Climatic change alters the frequency and intensity of natural hazards. In order to assess potential future changes in flood seasonality in the Rhine River Basin, we analyse changes in streamflow, snowmelt, precipitation, and evapotranspiration at 1.5, 2.0 and 3.0 ◦C global warming levels. The mesoscale Hydrological Model (mHM) forced with an ensemble of climate projection scenarios (five general circulation models under three representative concentration pathways) is used to simulate the present and future climate conditions of both, pluvial and nival hydrological regimes. Our results indicate that the interplay between changes in snowmelt- and rainfall-driven runoff is crucial to understand changes in streamflow maxima in the Rhine River. Climate projections suggest that future changes in flood characteristics in the entire Rhine River are controlled by both, more intense precipitation events and diminishing snow packs. The nature of this interplay defines the type of change in runoff peaks. On the sub-basin level (the Moselle River), more intense rainfall during winter is mostly counterbalanced by reduced snowmelt contribution to the streamflow. In the High Rhine (gauge at Basel), the strongest increases in streamflow maxima show up during winter, when strong increases in liquid precipitation intensity encounter almost unchanged snowmelt-driven runoff. The analysis of snowmelt events suggests that at no point in time during the snowmelt season, a warming climate results in an increase in the risk of snowmelt-driven flooding. We do not find indications of a transient merging of pluvial and nival floods due to climate warming.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1164
Microbiome-gut-brain axis and dietary interventions in Parkinson’s disease
Creators: name: Keymanesh, Shayan
Publisher: name: University of British Columbia
Year: 2023

description: Parkinson’s disease (PD) is a complex neurodegenerative disorder with a multifaceted etiology involving the nervous, gastrointestinal, and immune systems. Although motor dysfunctions are the most notable clinical feature of PD, the disease is also associated with various non-motor symptoms, many of which occur before the onset of motor signs. Prodromal gastrointestinal symptoms, alterations in the gut microbiome, and trans-vagal propagation of α-synuclein aggregates from the gut to the brainstem suggest a possible intestinal origin for PD. Another pathophysiological feature of PD is the inefficient utilization of glucose by neuronal cells, which leads to bioenergetic deficits in the brain. Current PD therapies only provide symptomatic relief without addressing the underlying causes. Therefore, dietary interventions have emerged as a promising therapeutic approach that can target multiple disease mechanisms. For example, the Mediterranean diet (MeDi) and the ketogenic diet (KD) have shown promise in alleviating gastrointestinal and bioenergetic deficits in PD, respectively, while providing symptomatic relief. The KD provides an alternative source of energy to the brain, while the MeDi replenishes the population of short-chain fatty acid (SCFA)-producing bacteria. However, classical KDs may unfavorably alter the gut microbiome and decrease SCFA levels. Therefore, combining the principles of the MeDi and KD may allow us to harness the potential benefits of both dietary interventions while maintaining gut health. This thesis will analyze the literature on PD pathophysiology, particularly with respect to the microbiome-gut-brain axis, as well as the biological mechanisms of dietary interventions to propose a mechanistic framework for the application of Mediterranean-ketogenic diets in PD. Additionally, to investigate the safety and feasibility of Mediterranean-ketogenic diets (MeDi-KD) and MeDi diets supplemented with medium-chain triglycerides (MeDi-MCT) in PD patients, an open-label, randomized, cross-over clinical trial was designed, the protocol for which will also be presented.
Science to policy discussion workshop: presentations
Creators: name: Grist, Hannah
name: Cunningham, Stuart
Publisher: name: Zenodo
Year: 2020
Subjects: policy, ocean science, oceanography, climate change,

description: Presentations given as part of the Ocean Systems workshop at SAMS on 28th July 2020. Discussion event around the engagement of ocean science with policy, using examples from project such as Blue-Action.
Orchis provincialis subsp. pauciflora (Ten.) Camus 1908
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis provincialis
Pauciflora (ten.) camus

description: (b) Subsp.pauciflora (Ten.) Camus, Monogr. Orchid. Europ. 160 (1908): Leaves usually without spots. Spike lax, with 3-7 flowers. Labellum 13-15 x 13-15 mm. Balkan peninsula and E. & C. Mediterranean region.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
title: Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism and insulin sensitivity in the hypothalamus
Creators: name: Wardelmann, Kristina
name: Rath, Michaela
name: Castro, José Pedro
name: Blümel, Sabine
name: Schell, Mareike
name: Hauffe, Robert
name: Schumacher, Fabian
name: Flore, Tanina
name: Ritter, Katrin
name: Wernitz, Andreas
name: Hosoi, Toru
name: Ozawa, Koichiro
name: Kleuser, Burkhard
name: Weiß, Jürgen
name: Schürmann, Annette
name: Kleinridders, André
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie

description: Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. Although insulin activates this response and improves metabolism, the metabolic impact of one of its members, the mitochondrial chaperone heat shock protein 10 (Hsp10), is unknown. Thus, we hypothesized that a reduction of Hsp10 in hypothalamic neurons will impair mitochondrial function and impact brain insulin action. Therefore, we investigated the role of chaperone Hsp10 by introducing a lentiviral-mediated Hsp10 knockdown (KD) in the hypothalamic cell line CLU-183 and in the arcuate nucleus (ARC) of C57BL/6N male mice. We analyzed mitochondrial function and insulin signaling utilizing qPCR, Western blot, XF96 Analyzer, immunohistochemistry, and microscopy techniques. We show that Hsp10 expression is reduced in T2D mice brains and regulated by leptin in vitro. Hsp10 KD in hypothalamic cells induced mitochondrial dysfunction with altered fatty acid metabolism and increased mitochondria-specific oxidative stress resulting in neuronal insulin resistance. Consequently, the reduction of Hsp10 in the ARC of C57BL/6N mice caused hypothalamic insulin resistance with acute liver insulin resistance.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1165
Habeas Corpus, em virtude de prisão ilegal - Artº 222º, do CPP, 1987 - Da Jurisprudência do Supremo Tribunal de Justiça. Reflexões e subsídios para a Comissão Revisora do Código de Processo Penal
Creators: name: Maximiano, António Henrique Rodrigues
Publisher: name: Direito e Justiça
Year: 2022

description: Direito e Justiça, v. 11 n. 1 (1997)
title: Extracellular vesicles: potential mediators of psychosocial stress contribution to osteoporosis?
Creators: name: He, Yangyang
name: Wuertz-Kozak, Karin
name: Kuehl, Linn K.
name: Wippert, Pia-Maria
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie

description: Osteoporosis is characterized by low bone mass and damage to the bone tissue’s microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit as biological markers. We demonstrate that EVs are potential mediators of psychosocial stress and osteoporosis and may be beneficial in innovative research settings.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1166
Orchis anatolica Boissier 1844
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis anatolica

description: 21. O. anatolica Boiss., Diagn. PI. Or. Nov.1 (5): 56 (1844). Tubers subglobose or ovoid, sessile or shortly stipitate. Stem 15-40 cm, erect or slightly flexuous, with a basal rosette of 2-5 leaves and with sheaths above, naked in upper part. Leaves lanceolate or oblong, gradually narrowed towards the base. Spike ovoid, lax, few-flowered. Bracts lanceolate or linearlanceolate, 1 - to 3-veined, usually somewhat shorter than ovary. Flowers purple or pale pink. Outer perianth-segments 8-10 mm, oblong-ovate or -lanceolate, obtuse, the 2 lateral patent, the median oblong-lanceolate, directed downward or recurved; inner perianth-segments oblong-ovate, subobtuse. Labellum 10-14 (-17) x 10—14(—17) mm, obovate, 3-lobed; lateral lobes rhombic, truncate; middle lobe squarish, truncate or excised, longer than the lateral. Spur linear-conical, widened towards the mouth, longer than ovary. Islands of S. Aegean region. Cr Gr. (S. W. Asia.) Plants from Kriti, with larger, greenish-violet flowers, an elongated labellum and the spur conspicuously curved upwards, have been named subsp. sitiaca Renz, Feddes Repert. 30: 100 (1932). Their status requires investigation.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
title: Unravelling the relationship between teacher-assigned grades, student personality, and standardized test scores
Creators: name: Westphal, Andrea
name: Vock, Miriam
name: Kretschmann, Julia
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 37 Bildung und Erziehung

description: The Big Five personality traits play a major role in student achievement. As such, there is consistent evidence that students that are more conscientious receive better teacherassigned grades in secondary school. However, research often does not support the claim that students that are more conscientious similarly achieve higher scores in domain-specific standardized achievement tests. Based on the Invest-and-Accrue Model, we argue that conscientiousness explains to some extent why certain students receive better grades despite similar academic accomplishments (i.e., achieving similar scores in domain-specific standardized achievement tests). Therefore, the present study examines to what extent the relationship between student personality and teacher-assigned grades consists of direct as opposed to indirect associations (via subject-specific standardized test scores). We used a representative sample of 14,710 ninth-grade students to estimate these direct and indirect pathways in mathematics and German. Structural equation models showed that test scores explained between 8 and 11% of the variance in teacher-assigned grades in mathematics and German. The Big Five personality traits in students additionally explained between 8 and 10% of the variance in grades. Finally, the personality-grade relationship consisted of direct (0.02 | b| � 0.27) and indirect associations via test scores (0.01 | b| � 0.07). Conscientiousness explained discrepancies between teacher-assigned grades and students’ scores in domain-specific standardized tests to a greater extent than any of the other Big Five personality traits. Our findings suggest that students that are more conscientious may invest more effort to accomplish classroom goals, but fall short of mastery.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe; 719
A Zona Franca da Madeira e os Serviços Bancários: breve conspecto acerca da evolução do regime legal relativo ao âmbito de operação conexo à isenção de tributação sobre o rendimento
Creators: name: Ribeiro, Nuno De Sampayo
Publisher: name: Direito e Justiça
Year: 2022

description: Direito e Justiça, v. 11 n. 1 (1997)
Additional file 7 of Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1
Creators: name: Xia, Qian
name: Gao, Shuai
name: Han, Tangrui
name: Mao, Meng
name: Zhan, Gaofeng
name: Wang, Yonghong
name: Li, Xing
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 7: Tables. Antibodies and primers employed in this study.
Orchis quadripunctata Cyr. ex Ten. 1811
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Orchis
Orchis quadripunctata

description: 22. O. quadripunctata Cyr. ex Ten., FI. Nap.1, Prodr. 53 (1811). Tubers subglobose or ovoid. Stem 10-30 cm, erect or slightly flexuous, with a basal rosette of 2-4 leaves and with sheaths above, naked in upper part. Leaves oblong-lanceolate or -linear. Spike ovoid or cylindrical, many-flowered. Bracts lanceolate, 1 - to 3-veined, shorter than to as long as ovary. Flowers purple-violet or pinkish. Outer perianth-segments 3-5 mm, patent, ovate, obtuse, the median oblong to ovate, recurved; inner 2-5 mm, obliquely ovate, obtuse. Labellum orbicular or rhombic, white at the base, with purple spots, 3-lobed (rarely entire); lateral lobes 4-7 mm, convergent, cruciform or divergent, oblong, ovate or rhombic; middle lobe oblong or squarish, truncate. Spur filiform, not widened towards the mouth, about as long as ovary. Mediterranean region, from Sardegna eastwards. A 1 Cr Gr It Ju Sa Si.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.215522
An Everyday Affair: Violence Against Women during the Vietnam War
Creators: name: Anderson, Elizabeth (Liza)
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Vietnam War
history
American history
women’s and gender studies

description: Despite decades worth of analysis and investigation into the Vietnam War, violence against civilian women throughout the conflict has been largely overlooked by historians. Most accounts of the war include references to abuses perpetrated against civilian women by American servicemen, but this phenomenon is rarely the focus of individual study by historians. This thesis reexamines the history of violence against women during the war through the lens of women’s liberation and the #MeToo movement. In an endeavor to answer the question of why otherwise normal American men participated in violence against women throughout the war, I analyze testimony from more than 60 men and women who witnessed, experienced, or participated in sexual violence in Vietnam. I also rely on the broad body of literature surrounding war crimes and atrocities during the Vietnam War. The argument proceeds in three parts. First, I demonstrate that sexual violence, although not ubiquitously common, was a key aspect of many people’s experience in the war. Then, I argue that the conditions of the conflict facilitated this violence by providing the environment and culture for it to take place. Finally, I show that the culture within specific units made sexual violence more common.
Explicit and implicit warping for accurate human pose estimation and low-latency neural rendering
Creators: name: Yu, Frank
Publisher: name: University of British Columbia
Year: 2023

description: Deep neural networks have become an integral part of modern advances in the field of computer vision. However, these solutions are not practical when relying on increasingly large neural networks and diverse datasets to scale. Prior works demonstrate that embedding domain/application-specific knowledge in both the architecture design and training procedure is one way to improve scalability. In this thesis, we propose two methods that leverage domain knowledge, defined through explicit and implicit warping, to create more data and runtime efficient networks in two applications. First, we compute an explicit warping to disentangle the learning of camera intrinsic parameters from the human pose estimation pipeline. Our explicit warping takes into account the region of interest and the camera's focal length to define a perspective-correct crop. By including this as a preprocess or end-to-end component in the network, we significantly increase performance, especially in cases where the subject is near the boundary of the image. Second, we leverage the knowledge that sequential frames in talking-head video conferencing have significant visual overlap. Therefore, we design a simple and effective implicit warping strategy between timesteps to greatly decrease the latency and increase the framerate of talking-head neural rendering. Our proposed methods demonstrate significant improvements in accuracy and latency in their respective applications.
Additional file 8 of Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1
Creators: name: Xia, Qian
name: Gao, Shuai
name: Han, Tangrui
name: Mao, Meng
name: Zhan, Gaofeng
name: Wang, Yonghong
name: Li, Xing
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 8: Supplementary Materials and Methods
Anacamptis laxiflora (Lamarck) Bateman, Pridgeon & Chase 1779
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Anacamptis
Anacamptis laxiflora

description: 23. O. laxiflora Lam., Fl. Fr. 3: 504 (1779). Tubers subglobose or ellipsoid, subsessile or shortly stipitate. Stem 30-80 cm, erect or slightly flexuous, with 3-8 patent leaves. Leaves linear or lanceolate. Spike ovoid or cylindrical, lax. Bracts lanceolate, 3- to 7-veined, shorter to longer than ovary. Flowers purple. Outer perianth-segments 7-10 mm, oblong, obtuse, the 2 lateral deflexed, the median more or less erect; inner shorter, obliquely oblong. Labellum 6-12 x 8-12 mm, suborbicular, obovate or triangular-obovate, cuneate at the base; lateral lobes oblong or oblong-orbicular, deflexed after anthesis; middle lobe entire to shallowly 2-lobed. Spur cylindrical. W., C. & S. Europe, extending northwards to Gotland and eastwards to S. Russia. Al Au Be B 1 Bu Co Cr Cz Ga Ge Gr He Hs Hu It Ju Lu Po Rm Rs (C, W, E) Sa Si Su Tu. 1 Labellum subentire or indistinctly 3-lobed; leaves 1 -5-2-5 cm wide (c) subsp.elegans 1 Labellum distinctly 3-lobed; leaves usually 1 -2 cm wide 2 Middle lobe of labellum usually shorter than the lateral; spur widened at apex (a) subsp.laxiflora 2 Middle lobe of labellum as long as or longer than the lateral; spur usually narrowed at apex or of uniform width (b) subsp.palustris
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on pages 341-342, DOI: 10.5281/zenodo.215522
title: Mechanomyography and acceleration show interlimb asymmetries in Parkinson patients without tremor compared to controls during a unilateral motor task
Creators: name: Schaefer, Laura V.
name: Löffler, Nils
name: Klein, Julia
name: Bittmann, Frank N.
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie

description: The mechanical muscular oscillations are rarely the objective of investigations regarding the identification of a biomarker for Parkinson’s disease (PD). Therefore, the aim of this study was to investigate whether or not this specific motor output differs between PD patients and controls. The novelty is that patients without tremor are investigated performing a unilateral isometric motor task. The force of armflexors and the forearm acceleration (ACC) were recorded as well as the mechanomyography of the biceps brachii (MMGbi), brachioradialis (MMGbra) and pectoralis major (MMGpect) muscles using a piezoelectric-sensor-based system during a unilateral motor task at 70% of the MVIC. The frequency, a power-frequency-ratio, the amplitude variation, the slope of amplitudes and their interlimb asymmetries were analysed. The results indicate that the oscillatory behavior of muscular output in PD without tremor deviates from controls in some parameters: Significant differences appeared for the power-frequency-ratio (p = 0.001, r = 0.43) and for the amplitude variation (p = 0.003, r = 0.34) of MMGpect. The interlimb asymmetries differed significantly concerning the power-frequency-ratio of MMGbi (p = 0.013, r = 0.42) and MMGbra (p = 0.048, r = 0.39) as well as regarding the mean frequency (p = 0.004, r = 0.48) and amplitude variation of MMGpect (p = 0.033, r = 0.37). The mean (M) and variation coefficient (CV) of slope of ACC differed significantly (M: p = 0.022, r = 0.33; CV: p = 0.004, r = 0.43). All other parameters showed no significant differences between PD and controls. It remains open, if this altered mechanical muscular output is reproducible and specific for PD.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe; 720
title: Genomic consequences of human-mediated translocations in margin populations of an endangered amphibian
Creators: name: Cahsan, Binia De
name: Westbury, Michael V.
name: Paraskevopoulou, Sofia
name: Drews, Hauke
name: Ott, Moritz
name: Gollmann, Günter
name: Tiedemann, Ralph
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie

description: Due to their isolated and often fragmented nature, range margin populations are especially vulnerable to rapid environmental change. To maintain genetic diversity and adaptive potential, gene flow from disjunct populations might therefore be crucial to their survival. Translocations are often proposed as a mitigation strategy to increase genetic diversity in threatened populations. However, this also includes the risk of losing locally adapted alleles through genetic swamping. Human-mediated translocations of southern lineage specimens into northern German populations of the endangered European fire-bellied toad (Bombina bombina) provide an unexpected experimental set-up to test the genetic consequences of an intraspecific introgression from central population individuals into populations at the species range margin. Here, we utilize complete mitochondrial genomes and transcriptome nuclear data to reveal the full genetic extent of this translocation and the consequences it may have for these populations. We uncover signs of introgression in four out of the five northern populations investigated, including a number of introgressed alleles ubiquitous in all recipient populations, suggesting a possible adaptive advantage. Introgressed alleles dominate at the MTCH2 locus, associated with obesity/fat tissue in humans, and the DSP locus, essential for the proper development of epidermal skin in amphibians. Furthermore, we found loci where local alleles were retained in the introgressed populations, suggesting their relevance for local adaptation. Finally, comparisons of genetic diversity between introgressed and nonintrogressed northern German populations revealed an increase in genetic diversity in all German individuals belonging to introgressed populations, supporting the idea of a beneficial transfer of genetic variation from Austria into North Germany.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1168