cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop
Creators: name: Harrer, Dennis Christoph
name: Schenkel, Charlotte
name: Bezler, Valerie
name: Kaljanac, Marcell
name: Hartley, Jordan
name: Barden, Markus
name: Pan, Hong
name: Holzinger, Astrid
name: Herr, Wolfgang
name: Abken, Hinrich
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: CHIMERIC ANTIGEN RECEPTORS; CANCER; COSTIMULATION; GENERATION; CYTOKINE; PROTEIN; TRUCKS; CAR T-cells; TRUCK; inducible; negative feedback
subject: 610 Medizin

description: The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs), commonly referred to as "fourth generation" CAR T-cells, are designed to release engineered payloads upon CAR-induced T-cell activation. Building on the TRUCK technology, we aimed to generate CAR T-cells with a CAR-inducible artificial, self-limiting autocrine loop. To this end, we engineered CAR T-cells with CAR triggered secretion of type-1 interferons (IFNs). At baseline, IFN alpha and IFN beta CAR T-cells showed similar capacities in cytotoxicity and cytokine secretion compared to conventional CAR T-cells. However, under "stress" conditions of repetitive rounds of antigen stimulation using BxPC-3 pancreas carcinoma cells as targets, anti-tumor activity faded in later rounds while being fully active in destructing carcinoma cells during first rounds of stimulation. Mechanistically, the decline in activity was primarily based on type-1 IFN augmented CAR T-cell apoptosis, which was far less the case for CAR T-cells without IFN release. Such autocrine self-limiting loops can be used for applications where transient CAR T-cell activity and persistence upon target recognition is desired to avoid lasting toxicities.
Aepeomys Thomas 1898
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Aepeomys

description: Aepeomys Thomas 1898
Aepeomys Thomas 1898, Ann. Mag. Nat. Hist., ser. 7, 1: 452.
Type Species: Oryzomys lugens Thomas 1896
Species and subspecies: 2 species:
Species Aepeomys lugens (Thomas 1896)
Species Aepeomys reigi Ochoa G., Aguilera, Pacheco, and Soriano 2001
Discussion: Thomasomyini. Synonymized under Thomasomys by Osgood (1933 c), an arrangement followed by Ellerman (1941), Cabrera (1961), and Handley (1976); generic status maintained by Gyldenstolpe (1932), Gardner and Patton (1976), and Musser and Carleton (1993). Morphological recognition contrasted to Thomasomys sensu stricto by Ochoa G. et al. (2001); karyology reported by Gardner and Patton (1976) and Aguilera et al. (1994, 2000). Diagnosis and specific contents amended by Voss et al. (2002), who removed Aepeomys fuscatus J. A. Allen (1912) to Handleyomys and Aepeomys vulcani Thomas (1898) to Thomasomys (see those accounts).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1091, DOI: 10.5281/zenodo.7316535
Additional file 1 of Characteristics of gut microbiota of premature infants in the early postnatal period and their relationship with intraventricular hemorrhage
Creators: name: Zhao, Yunlong
name: Li, Shan
name: Zhang, Rui
name: Zhang, Xin
name: Shen, Qiuyue
name: Zhang, Xingyun
name: Tian, Tian
name: Hou, Xinlin
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Transient Retention of Photoreceptor Outer Segments in Matrigel-Embedded Retinal Organoids
Creators: name: Berber, Patricia
name: Bondarenko, Sofiia
name: Michaelis, Lisa
name: Weber, Bernhard Heinrich Friedrich
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: HUMAN FETAL; STEM-CELLS; induced pluripotent stem cells; retinal organoids; photoreceptors; outer segments; retinal pigment epithelium; ciliopathy
subject: 610 Medizin

description: Retinal organoids (ROs) are three-dimensional retinal tissues, which are differentiated in vitro from induced pluripotent stem cells (iPSC), ultimately forming all main retinal cell types under defined culture conditions. ROs show several highly specialized retinal features, including the outgrowth of photoreceptor outer segments (OSs). In vivo, the photoreceptor OSs are enveloped and maintained by protrusions of retinal pigment epithelium (RPE) cells, the so-called apical microvilli, while ROs fail to recapitulate this critical interaction in culture development. Here, we define specific co-culture conditions aiming to compensate for the missing physical proximity of RPE and OSs in RO development. Accordingly, functional RPE cells and ROs were differentiated simultaneously from the same iPSC clone, the former resulting in byproduct RPE or bRPE cells. While some co-culture approaches indicated a temporary functional interaction between bRPE and RO photoreceptors, they did not improve the photoreceptor histoarchitecture. In contrast, embedding ROs in a basement membrane extract without bRPE cells showed a robust improvement in the rate of photoreceptor OS retention. RO embedding is a quick and easy method that greatly enhances the preservation of photoreceptor OSs, an important structure for modelling retinal diseases with the involvement of photoreceptors.
Aepeomys lugens
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Aepeomys
Aepeomys lugens

description: Aepeomys lugens (Thomas 1896)
[Oryzomys] lugens Thomas 1896, Ann. Mag. Nat. Hist., ser. 6, 18: 306.
Type Locality: Venezuela, Mérida State, La Loma del Morro, 3000 m.
Vernacular Names: Merida Aepeomys.
Synonyms: Aepeomys ottleyi (Anthony 1932).
Distribution: Mérida Andes of Venezuela to Andean Ecuador.
Conservation: IUCN – Lower Risk (lc).
Discussion: Karyotype (2n = 28) reported by Aguilera et al. (2000), who noted its strong divergence from other Venezuelan series (2n = 44) later described as A. reigi (see next). Voss et al. (2002) confirmed the allocation of ottleyi as an example of A. lugens.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1091, DOI: 10.5281/zenodo.7316535
Diaphragmatic Injuries among Severely Injured Patients (ISS ≥ 16)—An Indicator of Injury Pattern and Severity of Abdominal Trauma
Creators: name: Schurr, Leonhard Andreas
name: Thiedemann, Claudius
name: Alt, Volker
name: Schlitt, Hans Jürgen
name: Götz, Markus
name: Riedl, Moritz
name: Brunner, Stefan Martin
name: Popp, Daniel
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: RUPTURE; MANAGEMENT; DIAGNOSIS; SCORE; emergency surgery; diaphragm; injury; abdominal trauma; major trauma; laparotomy
subject: 610 Medizin

description: Background and Objectives: Abdominal trauma among severely injured patients with an injury severity score (ISS) of 16 and above can lead to potentially life-threatening injuries that might need immediate surgical intervention. Traumatic injuries to the diaphragm (TID) are a challenging condition often accompanied by other injuries in the thoracoabdominal region. Materials and Methods: We retrospectively analyzed the occurrence and clinical course of TID among severely injured patients treated at our center between 2008 and 2019 and compared them to other groups of severely injured patients without TID. Results: Thirty-five patients with TID and a median ISS of 41 were treated in the period mentioned above. They were predominantly middle-aged men and mostly victims of blunt trauma as a consequence of motor vehicle accidents. A total of 70.6% had left-sided TID, and in 69.6%, the size of defect was larger than 10 cm. The diagnosis was made with computed tomography (CT) in 68.6% of the cases, while in 25.8%, it was made intraoperatively or delayed by a false-negative initial CT scan, and in 5.7%, an intraoperative diagnosis was made without preoperative CT imaging. Surgical repair was mostly conducted via laparotomy, performing a direct closure with continuous suture. A comparison to 191 patients that required laparotomy for abdominal injuries other than TID revealed significantly higher rates of concomitant injuries to several abdominal organs among patients suffering from TID. Compared to all other severely injured patients treated in the same period (n = 1377), patients suffering from TID had a significantly higher median ISS and a longer mean duration of hospital stay. Conclusions: Our findings show that TID can be seen as an indicator of particularly severe thoracoabdominal trauma that requires increased attention from the treatment team so as not to miss relevant concomitant injuries that require immediate intervention.
Thysanoplusia (Thysanoplusia) mulunga Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Thysanoplusia
Thysanoplusia mulunga

description: * Thysanoplusia (Thysanoplusia) mulunga (Dufay, 1972)
(Fig. 10, 49, 50, 51)
Material examined. Gambella region, Gambella. 400 m. VIII.1987. Leg. Kravchenko V.
Literature. Dufay 1972.
General distribution pattern. The species was known only from Democratic Republic of Congo (Kivu, Mulungu).
Distribution in Ethiopia. Western Ethiopia (Gambella region). Rare.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on pages 238-239, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
title: Activité du port de Saint-Malo – 1739 – Ars en Ré
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: épices et condiments

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1739 avec le port "Ars en Ré"
description: Marchandises arrivées à Saint-Malo : sel
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; épices et condiments
description: Coverage: Grand cabotage
description: Bibliographic citation: GUILLAUME, Thérèse-Nicole. Trafic portuaire malouin en 1739 et 1742. DES : Histoire : Rennes : 1964 (Bibliothèque François-Lebrun, MH 1034)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Nebria schawalleri SHILENKOV 1998
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria schawalleri

description: Nebria schawalleri SHILENKOV, 1998
Holotype ♀: Nepal, Taplejung distr., ascent to Tangje La NW Walungchung Gola, 4400 –4600 m, alpine steppe, 23.V.1988, leg. Martens & Schawaller (SMNS).
Additional non-type material examined: 14 specimens, Nepal, Mechi province, Taplejung distr., 500 m NE Ghunsa, 27°39'48" N, 87°56'36" E, 3500– 3600 m, stone debris/mix. forest, 10. V. 2003, leg. A. Weigel (NME, cSCHM); 16 specimens Nepal, Mechi province, Taplejung distr., 13 km NE Ghunsa, Ghunsa Khola between Kambachen and Lhonak, 27°45'50" N, 87°59'49" E, 4200–4800 m, waterfall, alpine mats, stone debris, 14. V. 2003, leg. E. Grill (NME, cSCHM); 5 specimens Nepal, Mechi province, Taplejung distr., 5 km S Ghunsa, Camp nr. Sele La, 27° 37'05" N, 87°56'29" E, 4200 m, alpine mats & stone debris, 16. V. 2003, leg. A. Weigel (NME).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 8, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Aepeomys reigi Ochoa G., Aguilera, Pacheco, and Soriano 2001
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Aepeomys
Aepeomys reigi

description: Aepeomys reigi Ochoa G., Aguilera, Pacheco, and Soriano 2001
Aepeomys reigi Ochoa G., Aguilera, Pacheco, and Soriano 2001, Z. Saugetierk., 66: 230.
Type Locality: Venezuela, Lara State, Parque Nacional Yacambu, 17 km SE Sanare, El Blanquito, 1600 m; 09º40′N, 69º37′W.
Vernacular Names: Reig's Aepeomys.
Distribution: Venezuelan Andes (Lara and Trujillo), 1600-3230 m, W Venezuela.
Discussion: Morphologically similar to A. lugens but size larger and chromosomal formula very different, 2n =44 versus 2n = 28 in A. lugens (Aguilera et al., 1994, 2000).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1091, DOI: 10.5281/zenodo.7316535
Thysanoplusia (Thysanoplusia) clarci Hampson 1910
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Thysanoplusia
Thysanoplusia clarci

description: * Thysanoplusia (Thysanoplusia) clarci Hampson, 1910
(Fig. 11)
Material examined. Bako Gazer woreda, Mago National Park. 600 m. VIII.2011. Leg. Kravchenko V. Literature. Hampson 1913.
General distribution pattern. In South Africa, Zimbabwe.
Distribution in Ethiopia. Southern Ethiopia (Omo region). Rare.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 239, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Nebria rotundicollis subsp. tenuis HEINZ
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria rotundicollis
Nebria rotundicollis tenuis heinz

description: Nebria rotundicollis tenuis HEINZ & LEDOUx, 1989
Holotype ♂: Holotypus [red label] // Pakistan (Gilgit-Agency), Umg. Naltar 3000–3700 m, 30. 6.–4.8.1986, leg. Heinz [handwritten] // N. (Epinebriola) nouristanensis tenuis G. Ledoux det. 1987 [handwritten] (SMNS).
Paratypes: 11 specimens same data as holotype (SMNS).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 8, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Fluorescein-guided resection of newly diagnosed high-grade glioma: Impact on extent of resection and outcome
Creators: name: Schebesch, Karl-Michael
name: Höhne, Julius
name: Rosengarth, Katharina
name: Noeva, Ekaterina
name: Schmidt, Nils Ole
name: Proescholdt, Martin A.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Fluorescein sodium, Fluorescence-guided surgery, High-grade glioma,Neuro-oncologic surgery, Extent of resection, Malignant brain tumors, Neuro-oncology
subject: 610 Medizin

description: Introduction
Maximal resection of high-grade glioma (HGG) improves progression–free survival (PFS) and overall survival (OS). Fluorescein sodium (FL) in combination with the YELLOW 560 ​nm filter (Carl Zeiss Meditec, Germany) is a safe and feasible method of visualizing residual tumor tissue during brain tumor resection.

Research question
We hypothesized that use of FL positively influenced the volumetric extent of resection (EOR), PFS, and OS in patients undergoing resection of a newly diagnosed HGG.

Materials and method
Using a prospective HGG registry, we identified 347 patients (median age 62.4 years; 141 women) with preoperative high-quality magnetic resonance images for volumetric analysis. Resection was performed under white light in n ​= ​151 (43.5%, white-light group) and under FL-guidance in n ​= ​196 (56.5%, FL group). Sex, age, presurgical Karnofsky Performance Index (KPI), O6-Methylguanin-DNA-Methyltransferase-Gene (MGMT) status, and adjuvant treatment modalities were well balanced between the groups. Volumetric analysis was performed by quantifying pre- and postoperative tumor volume based on gadolinium-enhanced T1 sequences in a blinded fashion.

Results
In the FL group, postoperative tumor volume was significantly smaller (p ​= ​0.003); accordingly, quantitative EOR was significantly larger (p ​= ​0.003). Significantly more complete resections were achieved in the FL group than in the white-light group (p ​= ​0.003). The FL group showed significantly longer PFS (p ​= ​0.020) and OS (p ​= ​0.015, log rank testing). Multivariate Cox regression modelling showed age, presurgical KPI, MGMT status, and FL-guided resection to be independent prognostic factors for survival.

Discussion and conclusion
Compared to white-light resection, FL-guided resection of newly diagnosed HGG significantly improved EOR and prolonged OS.
Additional file 1 of Transforming nursing work environments: the impact of organizational culture on work-related stress among nurses: a systematic review
Creators: name: Kiptulon, Evans Kasmai
name: Elmadani, Mohammed
name: Limungi, Godfrey Mbaabu
name: Simon, Klara
name: Tóth, Lívia
name: Horvath, Eva
name: Szőllősi, Anna
name: Galgalo, Dahabo Adi
name: Maté, Orsolya
name: Siket, Adrienn Ujváriné
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
Insulatitan longipes Loew, comb. nov.
Creators: name: Webb, Donald W.
name: Metz, Mark A.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Therevidae
Insulatitan
Insulatitan longipes

description: Insulatitan longipes (Loew), comb. nov.
longipes Loew (1869: 8 male desc.), Kröber (1911: 499 male key, 500 fem. key, 506 add. desc.; 1913:31 listing; 1928:6 dist., 10 male key, 11 fem. key, 17 desc., Fig. 12 male ant., 56 add. desc., dist.) (Psilocephala); Irwin and Webb (1992:88, comb. change, checklist) (Penniverpa). Type locality Cuba. Holotype female in MCZ. New combination.
romaynae Metz and Irwin (2000:986 Fig. 28 phylog., 987 Fig. 29 male abd., 988 Fig. 35 fem. abd., 989 key, 992 Figs. 46– 47 male 993 Fig. 54 male genit., 994 Fig. 58 male genit., 995 male desc., 996 Figs. 62– 63 male genit., 997 dist.). Type locality Bahamas, Man O War Cay. Holotype male in CNC (MEI 079660). New synonym.
Psilocephala longipes (Loew) was placed in combination with Penniverpa by Irwin & Webb (1992) without any justification, but the distribution listed for the species in that article suggests that they were examining a heterogeneous assemblage of species. A re-examination of the holotype led us to conclude that it was a species of Insulatitan. The female holotype of P. longipes Loew is similar to females of Insulatitan in having the scutellum with two pair of marginal macrosetae; ocellar tubercle almost flush with frons, at least anteriorly; frons without pile, only silver, shiny pubescence present; height of frons at least two times width of frons at level of antennae; wing membranes pale brown with the margins of veins darkened; and tergite 4 of the female abdomen lacking pubescence (as in Fig. 35 Metz and Irwin 2000). In addition, female paratypes of Insulatitan romaynae Metz & Irwin were compared to the holotype female of Psilocephala longipes (Loew) and were determined to be conspecific.
description: Published as part of Webb, Donald W. & Metz, Mark A., 2008, A revision of the New World genus Penniverpa Irwin and Lyneborg (Diptera: Therevidae: Therevinae), pp. 1-45 in Zootaxa 1720 on pages 43-44, DOI: 10.5281/zenodo.181100
Case report: A complicated course of Collet-Sicard syndrome after internal carotid artery dissection and lenticulo-striatal artery infarction
Creators: name: Nowak, Dennis A.
name: Linden, Rainer
name: Arnold, Peggy
name: Seitz, Veronika
name: Stangl, Katrin
name: Wendl, Christina
name: Schlachetzki, Felix
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: PALSY; carotid artery dissection; dysphagia; dysphonia; skull base pathology; dysphagia and rehabilitation
subject: 610 Medizin

description: A 40-year-old Caucasian man presented with sudden onset of left-sided hemiparesis associated with dysphonia, dysphagia, and right-sided weakness on shoulder elevation and head rotation. The clinical examination revealed deviation of the tongue to the right, absence of right-sided gag reflex, right-sided palatal and vocal cord paresis, and weakness of the right trapezius and sternocleidomastoid muscles; all were in addition to left-sided brachiocephalic-accentuated hemiparesis. The diagnostic examination revealed dissection of the right carotid artery with occlusion of the middle cerebral artery and infarction in the lenticular-striatal artery territory. Mechanical thrombectomy with stent angioplasty of the right internal carotid artery was performed. The paresis of the left side of the body completely regressed within a week after symptom onset, but the dysphonia, weakness of the right trapezius and sternocleidomastoid muscles, and especially dysphagia persisted and regressed slowly but gradually. The patient required percutaneous gastric tube feeding for the next 12 weeks, possibly because of involvement of subcortical white matter tracts. The constellation of symptoms and clinical findings were consistent with Collet-Sicard syndrome, an extremely rare disorder caused by direct compression of the caudal cranial nerves at the base of the skull.
Akodon (Akodon) Meyen 1833
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon

description: Akodon (Akodon) Meyen 1833
Akodon (Akodon) Meyen 1833, Verhandl. Kais. Leop.-Carol. Akad. Wiss., Vol. 16, 2: 599.
Type Species: Akodon (Akodon) boliviensis Meyen 1833
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1091, DOI: 10.5281/zenodo.7316535
Additional file 2 of Transforming nursing work environments: the impact of organizational culture on work-related stress among nurses: a systematic review
Creators: name: Kiptulon, Evans Kasmai
name: Elmadani, Mohammed
name: Limungi, Godfrey Mbaabu
name: Simon, Klara
name: Tóth, Lívia
name: Horvath, Eva
name: Szőllősi, Anna
name: Galgalo, Dahabo Adi
name: Maté, Orsolya
name: Siket, Adrienn Ujváriné
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2.
Fraling, Bernhard / Hasenstab, Rudolf (Hrsg.): Die Wahrheit tun
Creators: name: Endres, J.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
Nebria tangjelaensis SHILENKOV 1998
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria tangjelaensis

description: Nebria tangjelaensis SHILENKOV, 1998
Holotype ♂: Nepal, Taplejung distr., ascent to Tangje La NW Walungchung Gola, 4800 –5000 m, alpine steppe, 23.V.1988, leg. Martens & Schawaller (SMNS).
Paratypes: 6 specimens same data as holotype (but at an altitude of 4400– 4600 m) (SMNS).
Additional non-type material examined: 2 specimens Nepal, Sankhua Wasabha, W-slope Lumba Sumba pass, 4830 m, 4.VII.2011, leg. S. Tamang, 27°44'24"N, 87°37'55"E (NMBE, cSCHM); 48 specimens Nepal, Sankhua Wasabha, E-slope Lumba Sumba pass, 4750 m, 5.VII.2011, leg. S. Tamang, 27°43'24"N, 87°39'20"E (NMBE, cSCHM).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on pages 8-9, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Additional file 1 of NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer
Creators: name: De La Cruz, Payton
name: McAdams, Julia
name: Morales Aquino, Melanie
name: Fernandez, Aileen I.
name: Elliott, Andrew
name: Lustberg, Maryam
name: Schorl, Christoph
name: Ribeiro, Jennifer R.
name: James, Nicole E.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Akodon (Microxus) Thomas 1909
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon

description: Akodon (Microxus) Thomas 1909
Species and subspecies: 41 species:
Species Akodon aerosus Thomas 1913
Species Akodon (Akodon) affinis J. A. Allen 1912
Species Akodon (Akodon) albiventer Thomas 1897
Species Akodon (Akodon) aliquantulus Díaz, Barquez, Braun, and Mares 1999
Species Akodon (Akodon) azarae (Fischer 1829)
Species Akodon bogotensis Thomas 1895
Species Akodon (Akodon) boliviensis Meyen 1833
Species Akodon (Hypsimys) budini Thomas 1918
Species Akodon (Akodon) cursor Winge 1887
Species Akodon (Akodon) dayi Osgood 1916
Species Akodon (Akodon) dolores Thomas 1916
Species Akodon (Akodon) fumeus Thomas 1902
Species Akodon (Akodon) iniscatus Thomas 1919
Species Akodon (Akodon) juninensis Myers, Patton, and Smith 1990
Species Akodon (Akodon) kofordi Myers and Patton 1989
Species Akodon (Microxus) latebricola Anthony 1924
Species Akodon (Akodon) leucolimnaeus Cabrera 1926
Species Akodon (Akodon) lindberghi Hershkovitz 1990
Species Akodon (Akodon) lutescens J. A. Allen 1901
Species Akodon (Microxus) mimus Thomas 1901
Species Akodon (Akodon) molinae Contreras 1968
Species Akodon (Akodon) mollis Thomas 1894
Species Akodon (Akodon) montensis Thomas 1913
Species Akodon (Akodon) mystax Hershkovitz 1998
Species Akodon (Akodon) neocenus Thomas 1919
Species Akodon (Akodon) oenos Braun, Mares, and Ojeda 2000
Species Akodon (Akodon) orophilus Osgood 1913
Species Akodon (Akodon) paranaensis Christoff, Fagundes, Sbalqueiro, Mattevi, and Yonenaga-Yassuda 2000
Species Akodon (Akodon) pervalens Thomas 1925
Species Akodon (Akodon) reigi González, Langguth, and Oliveira 1998
Species Akodon (Akodon) sanctipaulensis Hershkovitz 1990
Species Akodon (Akodon) serrensis Thomas 1902
Species Akodon (Hypsimys) siberiae Myers and Patton 1989
Species Akodon (Akodon) simulator Thomas 1916
Species Akodon (Akodon) spegazzinii Thomas 1897
Species Akodon (Akodon) subfuscus Osgood 1944
Species Akodon (Akodon) surdus Thomas 1917
Species Akodon (Akodon) sylvanus Thomas 1921
Species Akodon (Akodon) toba Thomas 1921
Species Akodon (Akodon) torques Thomas 1917
Species Akodon (Akodon) varius Thomas 1902
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1091, DOI: 10.5281/zenodo.7316535
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation
Creators: name: Matos, Carina
name: Mamilos, Andreas
name: Shah, Pranali N.
name: Meedt, Elisabeth
name: Weber, Daniela
name: Ghimire, Saroj
name: Hiergeist, Andreas
name: Gessner, André
name: Dickinson, Anne M.
name: Dressel, Ralf
name: Walter, Lutz
name: Stark, Klaus J.
name: Heid, Iris M.
name: Poeck, Hendrik
name: Edinger, Matthias
name: Wolff, Daniel
name: Herr, Wolfgang
name: Holler, Ernst
name: Kreutz, Marina
name: Ghimire, Sakhila
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: HUMAN RECIPIENTS; MARROW; VDR; HSCT; acute GI-GvHD; TRM; defensins
subject: 610 Medizin

description: The vitamin D receptor (VDR) is critical in regulating intestinal homeostasis and emerging evidence demonstrates that VDR deficiency is a critical factor in inflammatory bowel disease pathology. However, no clinical data exist regarding the intestinal expression of VDR in patients after allogeneic haematopoietic stem cell transplantation (HSCT). Analyzing intestinal biopsies from 90 patients undergoing HSCT with mortality follow-up, we demonstrated that patients with severe acute gastrointestinal graft versus host disease (GI-GvHD) showed significant downregulation of VDR gene expression compared to mild or no acute GI-GvHD patients (p = 0.007). Reduced VDR expression was already detectable at acute GI-GvHD onset compared to GvHD-free patients (p = 0.01). These results were confirmed by immunohistochemistry (IHC) where patients with severe acute GI-GvHD showed fewer VDR+ cells (p = 0.03) and a reduced VDR staining score (p = 0.02) as compared to mild or no acute GI-GvHD patients. Accordingly, low VDR gene expression was associated with a higher cumulative incidence of treatment-related mortality (TRM) (p = 1.6x10-6) but not with relapse-related mortality (RRM). A multivariate Cox regression analysis identified low VDR as an independent risk factor for TRM (p = 0.001, hazard ratio 4.14, 95% CI 1.78-9.63). Furthermore, VDR gene expression significantly correlated with anti-microbial peptides (AMPs) gene expression (DEFA5: r = 0.637, p = 7x10-5, DEFA6: r 0 0.546, p = 0.001). In conclusion, our findings suggest an essential role of the VDR in the pathogenesis of gut GvHD and the prognosis of patients undergoing HSCT.
Thysanoplusia (Daubeplusia) daubei Boisduval 1840
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Thysanoplusia
Thysanoplusia daubei

description: * Thysanoplusia (Daubeplusia) daubei (Boisduval, 1840)
(Fig. 12)
Material examined. Somali region, Jijiga. 1600 m. VIII.2011. Leg. Kravchenko V.; Somali region, Handew. 1800 m. VIII. 2011. Leg. Kravchenko V.
Literature. Behounek et al. 2010; Dufay 1972; Dufay 1978; Goater et al. 2003; Wiltshire 1990.
General distribution pattern. Widespread in subtropical and tropical Asia; also widespread but local in southern Europe, Near East and Arabian Peninsula. In tropical and subtropical Africa: Democratic Republic of Congo, Senegal, South Africa and Zimbabwe.
Distribution in Ethiopia. lowland, steppe species, common in eastern Ethiopia.
Host plants. polyphagous. Recorded on Sonchus, Chondrilla, Cichorium (all Asteraceae) and Mentha (Lamiaceae).
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 239, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
title: Activité du port de Saint-Malo – 1762 – Les Sables-d'Olonne
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: épices et condiments

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1762 avec le port "Les Sables d'Olonne"
description: Marchandises arrivées à Saint-Malo : sel
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; épices et condiments
description: Coverage: Grand cabotage
description: Bibliographic citation: CHEREL, Marcel. L'Activité maritime de Saint-Malo en 1762. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1051)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Nebria (Epinebriola) K. DANIEL 1904
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria

description: Species groups in the subgenus Epinebriola K. DANIEL, 1904
Epinebriola was established by K. Daniel (1904) as a monospecific subgenus of the genus Nebria when he described N. oxyptera. Up to now the subgenus Epinebriola was erroneously applied to the brothers Karl and Josef Daniel (Löbl & Smetana 2003, Ledoux & Roux 2005), but Karl Daniel is definitely the sole author (see Daniel 1904, p. 79).
Ledoux & Roux (2005) redefined the subgenus Epinebriola and split out all taxa, which are gradually described, into four species groups:
• masrina species group: N. chitralensis SHILENKOV & HEINZ, 1988, N. kabakovi, SHILENKOV, 1982, N. masrina masrina ANDREWES, 1924, N. masrina calceata LEDOUx & ROUx, 2005, N. meurguesae LEDOUx, 1985, N. nouristanensis LEDOUx, 1985, N. oxyptera oxyptera K. DANIEL, 1904, N. oxyptera alzonai DEUVE & LEDOUx, 1989, N. rotundicollis rotundicollis HEINZ & LEDOUx, 1989, N. rotundicollis tenuis HEINZ & LEDOUx, 1989, N. poplii LEDOUx 1984, N. praelonga LEDOUx, 1985;
• ganeshi species group: N. barbata ANDREWES, 1929, N. ganeshi LEDOUx, 1984, N. restricta LEDOUx & ROUx, 2005;
• pindarica species group: N. pindarica ANDREWES, 1925, N. businkyorum LEDOUx & ROUx, 1997, N. laevistriata LEDOUx & ROUx, 1998;
• zayula species group: N. orestias ANDREWES, 1932, N. rasa ANDREWES, 1936, N. schawalleri SHILENKOV, 1998, N. tangjelaensis SHILENKOV,1998, N. zayula ANDREWES, 1936.
Some characters used in the redefinition of the subgenus Epinebriola by Ledoux & Roux (2005) are obviously inconstant. The penultimate palpomere of the labial palpus, for instance, is occasionally bisetose instead of trisetose, or the endophallus is variably formed. For these two characters a certain proximity to the subgenera Patrobonebria BäNNINGER, 1923 and Eunebria JEANNEL, 1937 respectively is given. Therefore we evaluate the subgenus Epinebriola to be paraphyletic as Ledoux & Roux (2005, p. 618) already did.
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on pages 9-10, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Hertz, Anselm / Korff, Wilhelm (Hrsg.): Handbuch der christlichen Ethik
Creators: name: Endres, J.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
Effect of functional relaxation on the quality of life in patients with periprosthetic joint infection: Protocol for a randomised controlled trial
Creators: name: Walter, Nike
name: Loew, Thomas
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: PRIMARY TOTAL HIP; COMPLEMENTARY THERAPY; KNEE ARTHROPLASTY; EFFICACY; DEPRESSION; INTERVENTION; ASTHMA; ORTHOPAEDIC & TRAUMA SURGERY; Knee; COMPLEMENTARY MEDICINE
subject: 610 Medizin

description: Introduction Periprosthetic joint infection (PJI) is a devastating complication in orthopaedic and trauma surgery, which puts a high burden on the patients involving recurrent hospitalisation, prolonged courses of antibiotic medication, severe pain and long periods of immobility as well as high levels of psychological distress. Thus, this multicentre study aims at implementing body-oriented psychotherapy in clinical practice and evaluating its therapeutic effect on the quality of life. Methods and analysis A prospective, parallel two-armed randomised controlled trial with approximately n=270 patients with verified PJI treated surgically with a one-staged exchange, or a two-staged exchange will be conducted. Functional relaxation (FR) therapy will be implemented as a group therapy. FR originally belongs to the psychodynamically based body-oriented psychotherapy. Intervention techniques consist of minute movements of small joints, which are performed during relaxed expiration accompanied by an exploration of differences of body feelings. A group will include 3-8 patients, led by a specialist physiotherapist certified in FR once a week. The participants are consecutively admitted to the class and participate in 12 sessions. The control group will consist of patients receiving an unspecific 'placebo relaxation' intervention for the same duration. The primary efficacy endpoint is the mental component summary and physical component summary of quality of life assessed by the 36-Item Short Form Health Survey (SF-36) after 6 months. Secondary outcomes include SF-36 scores after 12 months, consumption of pain medication, mobility measured by the Parker mobility score and the physical activity measured by daily steps with an accelerometer (actibelt). Ethics and dissemination Approval from the Ethical Committee of the University Hospital Regensburg was received (file number: 21-2226-101). Written, informed consent to participate will be obtained from all participants. Results will be made available in the form of peer-reviewed publications and presentation in congresses.
Paralytic Impact of Centrifugation on Human Neutrophils
Creators: name: Hundhammer, Tobias
name: Gruber, Michael A.
name: Wittmann, Sigrid
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: GRADIENT CENTRIFUGATION; INNATE IMMUNITY; PERCOLL; EXPRESSION; MAC-1; YIELD; neutrophils; PMNs; isolation; centrifugation; g-time; g-forces; impairment; neutrophil functions
subject: 610 Medizin

description: Centrifugation is a common step in most of the popular protocols for the isolation of neutrophils from whole blood. Inconsistent results from previous studies on neutrophils may originate from an underestimation of the centrifugation effect, as in consequence impaired, not native cells, being investigated. We hypothesize, that centrifugation significantly impairs major neutrophil functions. However, there is no data yet whether the application of g-force itself or the product of g-force and duration of centrifugation (="g-time") defines the impact on neutrophils. Neutrophils were isolated from whole blood via centrifugation with different g-times and subsequently analyzed via live cell imaging for migration, as well as via flow cytometry for oxidative burst and surface antigen expression. Chemotactic migration was significantly reduced with increasing g-time. Oxidative burst decreased likewise the higher the g-time applied. Expression of CD11b was no longer upregulated in response to an n-formylmethionine-leucyl-phenylalanine (fMLP) stimulus in neutrophils having experienced high g-time during the isolation process. We conclude that centrifugation "paralyzes" neutrophils in the form of a significant decrease in functionality. Future investigations on neutrophil granulocytes should reduce the g-time load as far as possible.
Nebria zayula ANDREWES 1936
Creators: name: Huber, Charles
name: Schmidt, Joachim
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Nebria
Nebria zayula

description: Nebria zayula ANDREWES, 1936
Holotype ♂: Holotype [round white label, red margined] // S.E. Tibet, Zayul, Atakang, 1933 [printed], 14'000 ft., 15. vii. Kang La [handwritten] // F. Kingdon Ward & R.J.H. Kaulback. B.M. 1934-41 [printed] // Nebria zayula Andr., Type [handwritten], H.E. Andrewes det. [printed] // Nebria zayula Andr., Holotype [handwritten], N.G. Stork det. 1981 [printed] (BMNH).
description: Published as part of Huber, Charles & Schmidt, Joachim, 2017, Notes on the Nebria subgenus Epinebriola K. DANIEL, 1904 with the description of Barbonebriola subgen. nov. and 13 new species from the Himalaya-Tibet orogen (Coleoptera, Carabidae, Nebriini), pp. 1-85 in Contributions to Natural History 36 on page 9, DOI: 10.5169/seals-787049, http://zenodo.org/record/6285683
Beken, Alain van der: L´Évangile en Afrique, vécu et commenté par des Bayaka
Creators: name: Grunert, E.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 25 (1984): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 25
Postoperative Delirium after Reconstructive Surgery in the Head and Neck Region
Creators: name: Taxis, Juergen
name: Spoerl, Steffen
name: Broszio, Andreas
name: Eichberger, Jonas
name: Grau, Elisabeth
name: Schuderer, Johannes
name: Ludwig, Nils
name: Gottsauner, Maximilian
name: Spanier, Gerrit
name: Bundscherer, Annika
name: Reichert, Torsten E.
name: Ettl, Tobias
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: CHARLSON COMORBIDITY INDEX; RISK-FACTORS; MAJOR HEAD; MOTOR SUBTYPES; CANCER; SYMPTOMS; delirium; head neck squamous cell carcinoma; HNSCC; free flap; Charlson Comorbidity Index
subject: 610 Medizin

description: Postoperative delirium (POD) is an acute and serious complication following extended surgery. The aim of this study was to identify possible risk factors and scores associated with POD in patients undergoing reconstructive head and neck surgery. A collective of 225 patients was retrospectively evaluated after receiving reconstructive surgery in the head and neck region, between 2013 to 2018. The incidence of POD was examined with regards to distinct patient-specific clinical as well as perioperative parameters. Uni- and multivariate statistics were performed for data analysis. POD occurred in 49 patients (21.8%) and was strongly associated with an increased age-adjusted Charlson Comorbidity Index (ACCI) and a prolonged stay in the ICU (p = 0.009 and p = 0.000, respectively). Analogous, binary logistic regression analysis revealed time in the ICU (p < 0.001), an increased ACCI (p = 0.022) and a Nutritional Risk Screening (NRS) score not equal 0 (p = 0.005) as significant predictors for a diagnosis of POD. In contrast, the extent of reconstructive surgery in terms of parameters such as type of transplant or duration of surgery did not correlate with the occurrence of POD. The extension of reconstructive interventions in the head and neck region is not decisive for the development of postoperative delirium, whereas patient-specific parameters such as age and comorbidities, as well as nutritional parameters, represent predictors of POD occurrence.
Akodon aerosus Thomas 1913
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Akodon
Akodon aerosus

description: Akodon aerosus Thomas 1913
Akodon aerosus Thomas 1913, Ann. Mag. Nat. Hist., ser. 8, 11: 406.
Type Locality: Ecuador, Tungurahua Prov., upper Río Pastaza, Mirador, 1500 m.
Vernacular Names: Yungas Akodont.
Synonyms: Akodon baliolus Osgood 1915.
Distribution: Upper montane forests along E Andean slopes, 1200-2000 m, in Ecuador, Perú, and C Bolivia (Anderson, 1997; Patton and Smith, 1992).
Conservation: IUCN – Lower Risk (lc).
Discussion: Type species of Chalcomys, usually placed as a synonym of the subgenus Akodon (Cabrera, 1961; Reig, 1987). Formerly included as a subspecies of A. urichi by Cabrera (1961), but Gardner and Patton (1976), noting the pronounced difference in diploid number, listed the two as separate species; we include urichi under Necromys (see that account). Probably more than one species yet masquerades under the name of A. aerosus (see Patton and Smith, 1992; Patton et al., 1990); status of surdus as a possible junior synonym needs resolution (see Patton and Smith, 1992). Anderson (1997) recognized baliolus as a valid subspecies for Bolivian populations.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1092, DOI: 10.5281/zenodo.7316535
Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria.
Creators: name: Simon, Michaela
name: Gerlach, Roman G.
name: Pfeifer, Yvonne
name: Pfennigwerth, Niels
name: Gatermann, Sören G.
name: Schröder, Agnes
name: Hiergeist, Andreas
name: Hamprecht, Axel
name: Rügamer, Tamara
name: Gessner, André
name: Jantsch, Jonathan
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Enterobacterales; Pseudomonas aeruginosa; metallo-beta-lactamases; ceftazidime-avibactam; zinc; antimicrobial susceptibility testing; Phoenix; Micronaut
subject: 610 Medizin

description: Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-beta-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-automated antimicrobial susceptibility testing system regarding its capability to detect phenotypic ceftazidime-avibactam resistance in 176 carbapenem-resistant, metallo-beta-lactamase-producing Enterobacterales and Pseudomonas aeruginosa isolates. Nine clinical isolates displayed ceftazidime-avibactam susceptibility in the semi-automated system and six of these isolates were susceptible by broth microdilution, too. In all nine isolates, metallo-beta-lactamase-mediated hydrolytic activity was demonstrated with the EDTA-modified carbapenemase inactivation method. As zinc is known to be an important co-factor for metallo-beta-lactamase activity, test media of the semi-automated antimicrobial susceptibility testing system and broth microdilution were supplemented with zinc. Thereby, the detection of phenotypic resistance was improved in the semi-automated system and in broth microdilution. Currently, ceftazidime-avibactam is not approved as treatment option for infections by metallo-beta-lactamase-producing, Gram-negative bacteria. In infections caused by carbapenem-resistant Gram-negatives, we therefore recommend to rule out the presence of metallo-beta-lactamases with additional methods before initiating ceftazidime-avibactam treatment.