cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anilocra Leach 1818
Creators: name: Kumar, Panakkool Thamban Aneesh Helna Ameri Kottarathil Appukuttannair Biju
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Cymothoidae
Anilocra

description: Genus Anilocra Leach, 1818
Anilocra Leach, 1818: 348, 350. — Desmarest, 1825: 306. — Milne-Edwards, 1840: 255. — Dana, 1853: 747. — Schioedte and Meinert, 1881: 100. — Gerstaecker, 1882: 231. — Richardson, 1905: 25. — Hale, 1926: 210. — Schultz, 1969: 153. — Kensley, 1978: 78. — Kussakin, 1979: 281. — Brusca, 1981: 140. — Brusca and Iverson, 1985: 45. — Bruce, 1987: 89. — Trilles, 1975: 303. — Trilles, 1994: 55. — Thatcher and Blumenfeldt, 2001: 270. — Welicky et al., 2017: 24. — Aneesh et al., 2019: 444. — Aneesh et al., 2021: 323.
Canolira Leach, 1818: 350.
Epichthyes Herklots, 1870: 122.
Type species: Anilocra physodes (Linnaeus, 1758).
description: Published as part of Kumar, Panakkool Thamban Aneesh Helna Ameri Kottarathil Appukuttannair Biju, 2022, Simultaneous double parasitism by the parasitic cymothoids (Crustacea: Isopoda) of two genera on a single host fish Tenualosa toli from India, pp. 1-8 in Nauplius (e 2022013) (e 2022013) 30 on page 5, DOI: 10.1590/2358-2936e2022013, http://zenodo.org/record/14667383
Timing of saccadic eye movements during an accumulative visual search task
Creators: name: Wu, Chia-Chien
Publisher: name: No Publisher Supplied
Year: 2012

description: The quality of visual performance depends on how efficiently saccades can be programmed.  During each intersaccadic pause, the visual system needs to evaluate the fixated content and also determine where to look next.  Most prior studies focused only on the spatial element of saccadic decisions but ignored the effect of time.  A good search strategy should be able to apportion time between saccade production rate and the accuracy of target selection to maximize the acquisition of information. The current work is interested in how time is used in saccadic planning and how people decide when to look next.     To answer these questions, a novel experiment was designed where subjects were asked to search through arrays of targets (thin circles containing oriented lines) embedded in non-targets (thicker circles), either to estimate a statistical property of the targets (mean orientation of the lines), or to just look at the targets.     Varying the visual similarity of targets and non-targets had large effects on both the probability of landing on a target and the number of circles fixated per second in both estimation and the look-only tasks.  Also, the eye dwelled longer on targets than on distractors even in the look-only task, where there was no need to evaluate target content.  Saccadic dwell times, however, were about the same, regardless of whether the eye moved next to a target or to a distractor.    The results show that the timing of saccades depends on (1) the currently fixated content, (2) accumulated evidence in eccentric vision and also (3) an internal timer. The strategy, which incorporates these three factors rather than simply relies on any one of them, may guarantee efficient use of time in saccadic planning.
Entocythere prisma Andolshek & Hobbs 1986, new species
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Entocythere
Entocythere prisma

description: Entocythere prisma Andolshek & Hobbs, 1986
1986 Entocythere prisma, new species. — Andolshek & Hobbs: iii, 1, 6, 7, 8, 9, 11, 18, 20, 21, 22, 28, 29, 33–36, Figs. 3j, k, 14, 18a–l (A, D, H, K, R, T).
2014a Entocythere prisma Andolshek & Hobbs, 1986.—Mestre, Monrós & Mesquita-Joanes: 931, 949 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 70, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Stegelytra neveosparsa
Creators: name: Mozaffarian, Fariba
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Stegelytra
Stegelytra neveosparsa

description: Stegelytra neveosparsa (Ghauri, 1972) (Figs 37 and 53)
Recorded damage and economic importance in the orchards of Iran: Moderate economic importance damage on Pyrus sp. (Rajabi 1991; Abaii 2000)
Recorded damage in the orchards of other parts of the world: Not recorded.
Recorded distribution in Iran: North and southwest (Mozaffarian & Wilson 2016).
Conclusion: Its pest status in Iran needs further confirmation. It was previously recorded under the name Stegelytra sororcula Dlabola, a junior synonym of S. neveosparsa.
description: Published as part of Mozaffarian, Fariba, 2018, An Identification key to the species of Auchenorrhyncha of Iranian fauna recorded as pests in orchards and a review on the pest status of the species, pp. 475-501 in Zootaxa 4420 (4) on page 490, DOI: 10.11646/zootaxa.4420.4.2, http://zenodo.org/record/1455385
Altered gray matter volume and structural co-variance in adolescents with social anxiety disorder: evidence for a delayed and unsynchronized development of the fronto-limbic system.
Creators: name: Liu, Zhen
name: Hu, Yang
name: Zhang, Yiwen
name: Liu, Wenjing
name: Zhang, Lei
name: Wang, Yunyi
name: Yang, Hanshu
name: Wu, Jingyi
name: Cheng, Wenhong
name: Yang, Zhi
Publisher: name: IEEE
Year: 2021
Subjects: Adolescents
brain development
fronto-limbic
gray matter volume
social anxiety disorder
structural co-variance
Adolescent
Brain
Female
Gray Matter
Humans
Image Processing, Computer-Assisted
Limbic System
Magnetic Resonance Imaging
Male
Phobia, Social
Socioeconomic Factors

description: BACKGROUND: Social anxiety disorder (SAD) is a prevalent mental disorder diagnosed in childhood and adolescence. Theories regarding brain development and SAD suggest a close link between neurodevelopmental dysfunction at the adolescent juncture and SAD, but direct evidence is rare. This study aims to examine brain structural abnormalities in adolescents with SAD. METHODS: High-resolution T1-weighted images were obtained from 31 adolescents with SAD (15-17 years) and 42 matching healthy controls (HC). We evaluated symptom severity with the Social Anxiety Scale for Children (SASC) and the Screen for Child Anxiety Related Emotional Disorders (SCARED). We used voxel-based morphometry analysis to detect regional gray matter volume abnormalities and structural co-variance analysis to investigate inter-regional coordination patterns. RESULTS: We found significantly higher gray matter volume in the orbitofrontal cortex (OFC) and the insula in adolescents with SAD compared to HC. We also observed significant co-variance of the gray matter volume between the OFC and amygdala, and the OFC and insula in HC, but these co-variance relationships diminished in SAD. CONCLUSIONS: These findings provide the first evidence that the brain structural deficits in adolescents with SAD are not only in the core regions of the fronto-limbic system, but also represented by the diminished coordination in the development of these regions. The delayed and unsynchronized development pattern of the fronto-limbic system supports SAD as an adolescent-sensitive developmental mental disorder.
Physical Activity, Diet and Menarche in a Multiethnic Cohort
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer is the most commonly diagnosed cancer in women. While the exact cause (or causes) of breast cancer remains unknown, certain features or aspects of a woman’s life appear to increase the chance that she may develop breast cancer during her lifetime. A woman who has her first menstrual period at an early age is more likely to be diagnosed with breast cancer than a woman who has her first menstrual period at a later age. Women who produce an egg during each menstrual cycle are also more likely to be diagnosed with breast cancer compared to women who do not produce an egg at each menstrual cycle.

 The primary purpose of this study is to examine certain behaviors, specifically what a woman eats and her amount of physical activity, and how these behaviors relate to when she had her first menstrual period and whether she produced an egg during her menstrual cycles after she began having periods. A group of almost 1400 girls of different ethnic backgrounds were asked questions about their physical activity and the types and amounts of foods they ate. These girls were initially in the 4th through 7th grades and participated in a study that lasted for four years. Each girl was asked about her diet and physical activity up to five times during the course of the study. A total of 180 girls were also tested to see if they produced an egg during menstrual cycles. This information will be analyzed to determine if diet and physical activity are related to a woman’s age at her first menstrual period or whether or not she is likely to produce an egg during her menstrual cycles.

 If a relationship is found between physical activity, diet and a woman’s age at her first menstrual period or whether or not she produces an egg during her menstrual cycles, then more information will be available to help explain why some women are more likely to be diagnosed with breast cancer. Also, a woman may be able to change her behavior and possibly lower her chances of being diagnosed with breast cancer. For example, if physical activity decreases the chances that a woman will produce an egg during her menstrual cycles, then encouraging a woman to participate in regular physical activity may be a simple and effective means of lowering her chances of being diagnosed with breast cancer during her lifetime.
Integrin Receptor Activation in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The major factor contributing to the morbidity and mortality of breast cancer is the metastasis and invasion of distant sites by breast carcinomas. The process of metastasis and invasion of tumor cells requires that these cells alter their ability to adhere to both surrounding cells and the extracellular matrix (ECM). Integrins are a family of cell surface proteins that anchor cells to specific component proteins of the ECM. The integrin receptors are known to be modulated quantitatively and qualitatively in cancer. We are interested in the qualitative modulation (i.e., affinity towards ECM component proteins outside the cell) of integrin function, which is thought to occur through the binding of other proteins inside the cell. We hypothesize that changes in integrin affinity towards the ECM can control the invasive and metastatic properties of breast cancer cells.

 We propose to identify and characterize breast cancer proteins that are involved in integrin affinity regulation. Our laboratory has developed a novel approach, which utilizes Chinese hamster ovary (CHO) cells having modified integrin receptors. Introduction of isolated ‘interior portions’ of integrins into cells suppresses the activation status of these receptors. Our strategy is to introduce additional copies of regulatory elements into these cells to ‘rescue’ integrin activation, and determine their effect on cell adhesion function. Thus, we can indirectly address the protein structural and sequence elements necessary for integrin affinity regulation. Our goal is to define these elements in breast cancer cells. We have already found a possible integrin regulatory protein in CHO cells. It is possible that either (i) this protein is also found in breast cancer cells or (ii) our approach can identify additional unique regulatory proteins in breast cancer.

 The characterization of these proteins that regulate cell adhesion will aid in the understanding of metastasis and invasion of breast carcinomas. The proposed work relates directly to the pathogenesis of breast cancer and may provide new diagnostic and therapeutic targets to aid in the detection and treatment of metastatic breast cancer.
Anaceratagallia laevis
Creators: name: Mozaffarian, Fariba
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Anaceratagallia
Anaceratagallia laevis

description: Anaceratagallia laevis (Ribaut, 1935) (Figs 40 and 56)
Recorded damage and economic importance in the orchards of Iran: Not recorded.
Recorded damage in the orchards of other parts of the world: In Europe, the species has been recorded as a potential vector for Bois noir/ Stolbur phytoplasma, Aster yellows (AY) in vineyards, the yellows phytoplasma to Catharantus roseus and potato plants and 16SrI-A phytoplasmas in carrot fields (Batlle et al. 2000; Drobnjaković et al. 2010; Orenstein et al. 2003; Orenstein et al. 2003).
Recorded distribution in Iran: North, centre and west (Mozaffarian & Wilson 2016).
Conclusion: The vector status of this species in Iran needs further study.
description: Published as part of Mozaffarian, Fariba, 2018, An Identification key to the species of Auchenorrhyncha of Iranian fauna recorded as pests in orchards and a review on the pest status of the species, pp. 475-501 in Zootaxa 4420 (4) on page 490, DOI: 10.11646/zootaxa.4420.4.2, http://zenodo.org/record/1455385
Pseudagrion munte Dijkstra, sp. nov.
Creators: name: Dijkstra, Klaas-Douwe B.
name: Kipping, Jens
name: Mézière, Nicolas
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Odonata
Coenagrionidae
Pseudagrion
Pseudagrion munte
Pseudagrion symoensii

description: Pseudagrion munte Dijkstra sp. nov. – Upemba Sprite (Type Photo 20, Photo 31, Fig. 13)
Taxonomy
Genetically close to the sympatric P. symoensii Pinhey, 1967 that is also endemic to Katanga’s high plateaus, but morphologically well-separated, and treated as a distinct species by Dijkstra & Clausnitzer (2014).
Material studied
Holotype ♂. RMNH.INS.505608, Congo-Kinshasa, Katanga, Upemba National Park, Munte, river with grassy verges, gallery patches and rapids in miombo woodland, 1450 m a.s.l. (8.77 ° S 26.84 ° E), 18 -xi- 2011, leg. K.-D.B. Dijkstra, RMNH.
Further material. 10 ♂ (RMNH.INS.505607), 1 ♀ (RMNH.INS.505606), as holotype, RMNH. 1 ♂, as holotype, CKJL.
Genetics
One unique haplotype (n = 3) close to four similar but distinct haplotypes (n = 7) of the sympatric P. symoensii.
Male morphological diagnosis
Similar to several highland species of the A-group of Pseudagrion by (a) the small size, Hw 18.5 –20.0 mm (n= 10); (b) the bluish green labrum that is narrowly black at its base, contrasting with black postclypeus; and (c) the frons and dorsum of the thorax and abdomen base that are pruinose with maturity. Differs from the somewhat similar P. vumbaense Balinsky, 1963, sympatric P. inconspicuum Ris, 1931 and syntopic P. spernatum Selys, 1881 by (1) the evenly pruinose dark mesepisternum without defined pruinose or pale ante-humeral stripes with maturity; (2) the black rather than pale brown or reddish Pt; (3) the entire dorsum of S 8 but only the basal half of S 9 being blue, rather than both segments completely blue dorsally or wholly pruinose; and (4) the cerci nearest to those of P. symoensii with an internal flange on the lower branch that extends almost to the base and ends in a sharp up-turned tooth, although this tooth is not as large and there is no additional tooth more basally and dorsally (Fig. 13). Note that latter species, while genetically and geographically close, is otherwise very different, e.g., with orange labrum and frons, and red Pt.
Etymology
Name refers to the type locality (noun in apposition).
Range and ecology
Grassy borders of open sections of the Munte, a small swift-flowing blackwater river with some gallery forest at 1 450 m a.s.l. on the otherwise open Kibara Plateau of Upemba National Park, Katanga (Photo 31).
description: Published as part of Dijkstra, Klaas-Douwe B., Kipping, Jens & Mézière, Nicolas, 2015, Sixty new dragonfly and damselfly species from Africa (Odonata), pp. 447-678 in Odonatologica 44 (4) on pages 528-529, DOI: 10.5281/zenodo.35388
Entocythere reddelli Hobbs & Walton 1968
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Entocythere
Entocythere reddelli

description: Entocythere reddelli Hobbs & Walton, 1968
1965 Entocythere sp.—Reddell: 156 (C, D, H).
1968 Entocythere reddelli new species.—Hobbs & Walton: 243–246, Fig. 2a–d (D, H, R, T).
1969 Entocythere reddelli Hobbs and Walton. —Reddell & Mitchell: 6, 27 (C, D, H).
1970 Entocythere reddelli Hobbs and Walton. —Reddell: 395 (C, D, H).
1971 Entocythere reddelli Hobbs and Walton, 1968:243.—Hobbs Jr.: 40, 53, 54 (D, K).
1974 Entocythere reddelli Hobbs and Walton, 1968.—Hart & Hart: 83, 92–93, 203 [as Entocythere redelli, erroneous spelling], 228, Pl. XXVII Figs. 11–15, Pl. LII (D, H, K, R, T).
1975 Entocythere reddelli Hobbs & Walton, 1968.—Hart & Hart: 35 (C, D, H).
1975 E. reddelli Hobbs and Walton, 1968. —Hobbs: 281 (C, D).
1977 Entocythere reddelli Hobbs and Walton. —Hobbs & Peters: iv, 5, 6, 7, 9, 10, 12, 14, 29, 36, 41, 43, 44, 47, 52, 54–55, 73, Fig. 27a–g, Map 12 (A, D, H, K, T).
1982 E. reddelli Hobbs and Walton (1968).—Hobbs & Peters: 314 (D, R).
1986 E. reddelli Hobbs and Walton (1968:243).—Andolshek & Hobbs: 30 (T).
1988 E. reddelli.—Tsukagoshi: 570 (C).
1999 Entocythere reddelli Hobbs & Walton. —Peters & Pugh: 342, 343, 346, 347, 348–349, Fig. 6 (A, D, H, T).
2014a Entocythere reddelli Hobbs & Walton, 1968.—Mestre, Monrós & Mesquita-Joanes: 949 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 70, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Is the 'rational actor' a Calhounian?
Creators: name: Kreider, Clement H.
Publisher: name: No Publisher Supplied
Year: 2012

description: Rational or Social Choice Theory is a growing Nobel Prize-winning field which seeks  to apply the formal methods of neoclassical or micro-economics to the study of voting.  Perhaps the field’s most striking finding is that majority voting is “irrational”, or highly  likely to issue in outcomes that are mathematically arbitrary and dictatorial or imposed,  while laissez-faire or approximately unanimous decision (minority veto) are found to be  “rational” and “optimal”. Diverse observers have noticed the distinct resemblance of such  “rational actor” models to the political theory of John C. Calhoun, the American antebellum  Southern Senator (the “Doctrine of the Concurrent Majority”). Using the usual  methods of traditional political theory, my work uncovers a paper trail of citation and  discussion of minority veto versus majority rule that goes back from Rational Choice  Theory to one Knut Wicksell, the great turn of the 20th century Swedish economist, and  from there through John Stuart Mill and Thomas Hare back to Calhoun himself. The  results of Rational Choice Theory are revealed to come from inherited ideas rather than  from formal logical or mathematical methods. This result in turn suggests significant  consequences for the methodology of economics in general as well as for the resultant  public policy proposals, such as the Social Choice-inspired Balanced Budget  Amendments, which would restrict majority control over taxation and fiscal policy, and  which have been under discussion in America and Europe since the 1980's
Delivery of therapeutic nanocarriers to tumors in vivo by targeting tumor-specific carbohydrate epitopes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A major goal in cancer research is the development of systems to deliver chemotherapeutic agents directly to tumor cells and away from normal tissue. Success in this endeavor will allow the use of lower doses of chemotherapeutic agents and will reduce side effects due to effects on normal tissues. The present project will take the novel approach of using immuno-liposome nanocarriers to target the carbohydrate components of extracellular matrix molecules that characterize tumor tissue, and deliver a chemotherapeutic agent through the fenestrated endothelium that characterizes tumor tissue, specifically to the tumor cells. Recent work in this laboratory has established the Hepa 129 hepatocellular carcinoma tumor model in mice. Results thus far demonstrate that the Hepa 129 tumors express chondroitin sulfate. Importantly, chondroitin sulfate is not detected in normal liver or other regions of the reticuloendothelial system. This differential distribution is expected to allow the selective targeting to the hepatocellular carcinoma cells and away from normal tissues. This project will use our nanoparticle system, which incorporates anti-chondroitin sulfate antibody fragments into liposomes, to target Hepa 129 tumor cells. Four Specific Aims include: 1) Test the specificity of targeting in vitro by applying immunoliposomes to slices of Hepa 129 tumor compared to normal liver and spleen; this in vitro model will be used to identify the best immunoliposome targeting formulations. 2) Test the specificity in vivo by systemically injecting immunoliposome formulations in mice that have ectopic Hepa 129 tumors. Blood clearance, tissue localization, and target specificity of the liposomes will be determined. 3) Incorporate doxorubicin into immunoliposomes and test for specificity of doxorubicin delivery to tumor cell nuclei. Blood clearance, tissue localization, and target specificity of the doxorubicin will be determined. 4) Administer these active targeting immunoliposomes to Hepa 129 tumor-bearing mice and test the chemotherapeutic efficacy, measured by reduction in tumor volume, compared to control formulations, including liposomes without antibody, liposomes with control antibody, and free (non-liposomal) doxorubicin. Because many and perhaps all tumors express glycosaminoglycans, the results of this study are expected to contribute to the development of tumor targeting strategies that will be applicable to a variety of tumor systems.
Fluid boundaries
Creators: name: Wise, Sarah Pence
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation examines how people negotiate rightful ownership and access to contested space undergoing governance change. Based on 24 months of ethnographic research on protected area conservation in The Bahamas, this dissertation explores how people maintain and transgress material and symbolic boundaries as the west side of Andros Island transitions from a locally-valued commons to globally-valued protected area. In response to growing global concerns over declining fisheries and vulnerability of small island nations, the Bahamas Government has declared large tracts of land and sea as protected areas throughout the archipelago nation. Andros Island, as the largest and most rural island, has been reconfigured as an ideal location for protection, as an island both abundant in natural resources and vulnerable to change. In Andros, access and ownership claims are managed though multilayered customs and laws including long-standing oral tenure institutions. Conservationists, Bahamian residents, scientists, and resource users claim rights of access to resources and space through socially embedded processes which create, impose, maintain, bridge, transpose and dispute boundaries. Discernible differences exist in each person’s claim, not only in the types of boundaries marked by individuals from different social spheres, but in how people enact a sense of entitlement and rightful claim through different ideas of legitimacy and belonging. My research finds that personal and social attributes such as class, race, and social and economic status inform how people: 1) perceive the environment as well as policies of protected area enclosure, and 2) negotiate particular spatial and social boundaries including property claims, knowledge claims, resource access rights, and belonging. What constitutes a rightful claim of access and ownership is not a fixed phenomenon, but reflects fluid social positioning, such as racial identity, kinship, and knowledge performativity. Ignoring the divergence in how people make claims can lead to a mismatch in resource management strategies, (and ultimately to failed policy initiatives), as well as loss of material and symbolic wealth and security among people living near protected areas.
Quantitative in vivo assay for a metabolic target in melanoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Effective cancer treatments must exploit the key differences between cancer cells and normal cells. Peripheral metabolism offers an important inroad to cancer therapies. As a part of the collaborative effort between Professor Meyer and Professor Filipp, ELOVL6 was identified as potential therapeutic target against melanoma. ELOVL6 is the major elongase in humans and take a pivotal role in fatty acid metabolism in human cancer. The objective of this proposal is to develop a quantitative in vivo assay for ELOVL6 activity. Fulfillment of this objective will facilitate the discovery of potential therapeutics. We propose to synthesize terminally-labeled palmitic acid that can be exogenously fed to melanoma cells. The additional three atomic mass units contributed by the deuterium label will enable us to use mass spectrometry to quantitatively assay the fatty acid distribution that results from the input of labeled palmitic acid into the metabolic network containing ELOVL6. To calibrate this assay, the fatty acid distributions from untreated and siRNA ELOVL6 knock-down cultures of melanoma cells will be quantitatively determined. The assay will be validated using a putative elongase inhibitor. The PI of this proposal, Prof. Meyer, has extensive experience in synthesizing deuterium-labeled fatty acids and in assaying enzymes involved in downstream modification of polyunsaturated fatty acids. Professor Filipp has extensive experience using high-throughput screening techniques to study metabolic networks concerned with fatty acid metabolism in cancer. This proposal, if funded, will enable further collaboration between the Meyer and Filipp labs. The data obtained from the research proposed here will be used as preliminary data for future applications for R21 or R01 awards from the National Cancer Institute at NIH.
Agarna Schiodte and Meinert 1884
Creators: name: Kumar, Panakkool Thamban Aneesh Helna Ameri Kottarathil Appukuttannair Biju
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Cymothoidae
Agarna

description: Genus Agarna Schiödte and Meinert, 1884
Agarna Schiödte and Meinert, 1884: 329. — Barnard, 1936: 170. — Tiwari, 1952: 295–300, pl. iv, text figs. 1–2. — Pillai, 1954: 16. — Bowman and Tareen, 1983: 21, — Aneesh, 2014: 36. — Aneesh et al., 2018: 3.
Type species. Agarna cumulus (Haller, 1880).
description: Published as part of Kumar, Panakkool Thamban Aneesh Helna Ameri Kottarathil Appukuttannair Biju, 2022, Simultaneous double parasitism by the parasitic cymothoids (Crustacea: Isopoda) of two genera on a single host fish Tenualosa toli from India, pp. 1-8 in Nauplius (e 2022013) (e 2022013) 30 on page 4, DOI: 10.1590/2358-2936e2022013, http://zenodo.org/record/14667383
Pseudagrion pacale Dijkstra, sp. nov.
Creators: name: Dijkstra, Klaas-Douwe B.
name: Kipping, Jens
name: Mézière, Nicolas
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Odonata
Coenagrionidae
Pseudagrion
Pseudagrion pacale

description: Pseudagrion pacale Dijkstra sp. nov. – Peace Sprite (Type Photo 21, Photos 32, 75, Fig. 12)
Taxonomy
Belongs to a subgroup of Pseudagrion B-group species that favour larger and swifter flowing waters. These include P. acaciae Förster, 1906, P. sublacteum (Karsch, 1893), P. vaalense Chutter, 1962 and probably P.niloticum Dumont, 1978. Present species is morphologically and genetically clearly differentiated.
Material studied
Holotype ♂. RMNH.INS.501668, Sierra Leone, Eastern Province, 7 km S of Kenema, Moa River at Tilorma, large river with gallery forest and rocky rapids (Photo 32), 147 m a.s.l. (7.8123 ° N 11.1779 ° W), 26 -ii- 2011, leg. K.- D.B. Dijkstra, RMNH.
Further material. 2 ♂ (RMNH.INS.501661, RMNH.INS.501670), 1 ♀ (RMNH.INS.501669), as holotype, RMNH. 3 ♂ (RMNH.INS.501674), 1 ♀, same locality, 15 -iii- 2011, leg. K.-D.B. Dijkstra, RMNH.
Genetics
Two unique haplotypes (n = 5) distant from but nearest to P. sublacteum; more distant to P. acaciae and P. vaalense; P. niloticum not sampled.
Male morphological diagnosis
Nearest to P. sublacteum by (a) the essentially similar markings including reddish eyes, face and ante-humeral stripes; (b) the broad lateral and apical lobes of the penis; (c) the narrow and slender cerci that clearly surpass the paraprocts; and (d) the hatchet-shaped paraprocts, with a prominent dorsal knob in lateral view (Fig. 12). However, (1) is larger, Hw 21.5 –24.0mm (n = 6) rather than 18.5 –21.0 mm (n = 6); (2) the postocular spots and antehumeral stripes become deep orange and the thorax sides pale green with maturity, rather than all turning dark and eventually uniformly pruinose; (3) the postocular spots are clearly framed with black; (4) the apical cleft of the penis is deep and narrow, while its wide lateral lobes bear tiny projections, thus the penis most recalls that of P. coeleste Longfield, 1947; (5)the paraprocts are pointed rather than rounded in dorsal view; and (6) the dorsal knob of the paraprocts is much higher than deep and thus more pronounced than in other African Pseudagrion species (Fig. 12).
Etymology
Latin “belonging to peace” to contrast with the 1991–2002 civil war in which the Moa River was a frontline and the Ebola epidemic since 2013 of which the Kenema region was the national epicentre (neuter adjective).
Range and ecology
Rocky sections with rapid flow of the broad Moa River between 120 and 150m a.s.l. in Sierra Leone; also seen at Tiwai Island, 35 km downstream of the type locality.
description: Published as part of Dijkstra, Klaas-Douwe B., Kipping, Jens & Mézière, Nicolas, 2015, Sixty new dragonfly and damselfly species from Africa (Odonata), pp. 447-678 in Odonatologica 44 (4) on pages 530-532, DOI: 10.5281/zenodo.35388
Virus-induced genomic instability in Merkel cell carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Merkel cell carcinoma (MCC) is a rare but highly aggressive type of skin cancer that is increasing in incidence. Although a new virus, the Merkel cell polyomavirus (MCV), has been identified and is strongly associated with MCC, the actual mechanisms by which the virus contributes to MCC pathogenesis remain unknown. However, the widespread presence of the virus in the general population and the sun-exposed distribution of MCC suggest that MCV exposure is insufficient for MCC development but rather predisposes to photocarcinogenesis. Consistent with MCV promoting genomic instability, we have recently discovered that MCV infection is associated with deficiencies in DNA repair as well as in cell cycle arrest following ultraviolet radiation. Aberrant responses to ionizing radiation also are associated with MCV infection. Our preliminary data demonstrate that these defects are recapitulated by expression of the MCV large T antigen (LT). MCV LT is homologous to that of another polyomavirus—simian virus 40—which is well-documented to disrupt important nodes in the cellular DNA damage response, including p53 and Rb. The overall hypothesis to be tested by this proposal is that MCV infection and specifically LT disrupt pathways that regulate DNA repair and cell cycle checkpoints following DNA damage, leading to genomic instability in normal and tumor cells. In the proposed project, the hypothesis will be tested by the following Aims: In Aim 1, we will dissect the mechanism by which MCV and LT impair the response to ultraviolet radiation by functional and gene expression studies of cells expressing distinct LT mutants. In Aim 2, we will examine the consequences of genomic instability by testing the prediction that LT expression enhances mutation rates following ultraviolet and ionizing radiation. This project will contribute key insights into the role of MCV in MCC pathogenesis, and may ultimately explain the clinical evolution and therapeutic response of MCC tumors. The project may also have implications for guiding treatment and prognosis of MCC, and suggest DNA repair pathways as novel therapeutic targets.
Corrective justice, harm, and reparations for historical injustice
Creators: name: Winterbottom, Jonathan Paul
Publisher: name: No Publisher Supplied
Year: 2012

description: Some regard harms to currently existing persons as a basis for reparations for historical injustice.  By focusing on corrective justice as the basis for repairing wrongful harm, this thesis aims to clarify and strengthen the harm-based approach to reparations. I defend a version of the conformity account as the moral basis of corrective justice, critiquing various versions of this argument by Joseph Raz and John Gardner. I argue that the notion of harm relevant to corrective justice is a counterfactual comparative one and respond to various objections to that conception. I then consider two different cases in which compensation for an historical injustice might be thought appropriate. First, I examine an argument developed independently by Bernard Boxill and George Sher (which I refer to as the chain-harm argument). I analyze Andrew Cohen’s critique of the argument, clarifying the problems it faces before offering some tentative solutions. Second, I examine and critique Judith Jarvis Thomson’s proposal to solve the non-identity problem in the case of the Risky Policy. I explain why her argument fails and offer my own solution.
Entocythere ruibali Rioja 1955, n. sp.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Entocythere
Entocythere ruibali

description: Entocythere ruibali Rioja, 1955
1955 Entocythere ruibali n. sp. — Rioja: 194–196, Pl. I Figs. 2–8 (D, H, R, T).
1956 Entocythere ruibali Rioja (1955: 194).—Hobbs: 431–432, 433, 434, Fig. 8 (D, R, T).
1959 E. ruibali.—Hart: 201 (C, T).
1962 Entocythere ruibali Rioja. —Hart: 122, 132, 134 (C, D, T).
1968 E. ruibali Rioja, 1955.—Ferguson: 502 (C, D).
1969 Entocythere ruibali Rioja, 1955.—Straskraba: 9 (D, H).
1970 E. ruibali Rioja, 1955.—Hobbs & Hobbs: 11 (T).
1971 E. ruibali Rioja, 1955.— Hart, D.G. & Hart: 114 (T).
1971 Entocythere ruibali Rioja, 1955.—Hobbs Jr.: 2, 3, 4, 7, 14, 15, 16, 17, 20, 32, 40, 44, 53, 54, Figs. 7 [by implication], 29a–e (A, C, D, H, K, R, T).
1974 Entocythere ruibali Rioja, 1955.—Hart & Hart: 4, 15, 83, 84, 93, 203, 227, Pl. XXVII Figs. 16–18, Pl. LI (D, H, K, T).
1975 Entocythere ruibali Rioja, 1955.—Hart & Hart: 35 (C, D, H).
1994 Entocythere ruibali Rioja, 1955.—Martens & Behen: 31, 64 (C, D).
2001 Enthocythere ruibali Rioja, 1955.—Lalana & Ortiz: 104, erroneous spelling (C).
2014a Entocythere ruibali Rioja, 1955.—Mestre, Monrós & Mesquita-Joanes: 949 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on pages 70-71, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
She loved more ardently than the rest
Creators: name: Wilkins, Sarah Stewart
Publisher: name: No Publisher Supplied
Year: 2012

description: In 1279, Charles of Salerno, the future King Charles II of Naples, discovered the body of the repentant prostitute Mary Magdalen, the foremost exemplar of penance in the late medieval period, at the church of Saint-Maximin in Provence. Immediately afterwards the first cycles of paintings depicting her life appeared in Italy. The Angevin dynasty of Naples, along with the Franciscan and Dominican Orders, promoted the Magdalen cult and its spread into Italy, yet there has been little inquiry into their use of visual imagery in this endeavor. My dissertation investigates the iconography and patronage of the earliest central and southern Italian painted cycles depicting her life, providing the first exploration of the use of narrative imagery to aid in the construction and development of the identity of Mary Magdalen. The visual expression of this identity, as created in six critically important cycles in Naples, Assisi, and Florence, played a vital role in her cult’s expansion. I contend that these pictorial narratives, all connected to the key advocates of her cult, were not merely illustrating the Magdalen’s life as they were transmitted in textual accounts, but instead were consciously used to craft the identity of the saint. These cycles thus visualize mendicant and Angevin interpretations of the Magdalen.    The first chapter provides the historical context for interpreting the Magdalen pictorial vitae, presenting a summary of the biblical and legendary Magdalen literary material, and explaining her appeal for the three groups instrumental in promoting her cult in the period. It concludes with a discussion of the earliest Magdalen cycle, on the Magdalen Master Dossal in Florence. The second chapter explores the three Magdalen cycles in Naples within the context of Angevin promotion of the Magdalen cult. The third and fourth chapters investigate the Magdalen Chapel in the Basilica of St. Francis, Assisi, looking at the Magdalen cycle and the iconic imagery in the chapel as a Franciscan statement on penitence. The final chapter re-examines the Magdalen Chapel in the Palazzo del Podestà, Florence, arguing that it was a palace chapel commissioned by the Angevin Signore of Florence, King Robert.
Targeting p25 to tumors; A novel cancer therapeutic strategy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: CDK5/p35 is a neuron-specific protein kinase responsible for normal cortical development in mammals. Under certain neuropathological conditions, the p35 subunit can undergo proteolytic cleavage at the N-terminus to generate CDK5/p25, which instead is neurotoxic leading to neuronal cell death. Our laboratory and others have shown that expression of p25 in all cells including tumor cells causes robust cell death, because while only neurons normally express p25, all cells express CDK5. The goal of this study is to target p25 specifically to breast cancer tumors, where its toxic action is anticipated to kill tumor cells. Our collaborator, Dr. Erkki Rouslahti, in our department, has developed a tumor homing system in which a small peptide sequence, iRGD (CRGDKGPDC), is capable of homing specifically to tumor vasculature and internalizing bacteriophage particles or nanoparticles coated with this sequence. The system takes advantage of the specific affinity of iRGD to alpha v-integrin, which is robustly upregulated on the extracellular surface of blood vessels during angiogenesis associated with tumor growth. Once bound, iRGD undergoes proteolysis by a cell surface protease, is released from integrin, and the proteolytic product (CRGDK) is internalized via the neuropilin-1 receptor. While phage and nanosize particles have been targeted to and internalized into tumors by the iRGD peptide, the specific targeting and uptake of proteins by iRGD has not been demonstrated. In this proposal, we will test if p25 fused to iRGD can be targeted to tumors in tumor-bearing mice where it is expected to kill tumor cells. The specific aims are 1) to test if p25-iRGD can penetrate tumor cells in culture and cause cell death, followed by 2) testing if p25-iRGD specifically localizes to tumor tissue in tumor-bearing mice followed by its uptake and tumor cell death. This study will be the first to test the specific tumor targeting of p25 by iRGD, and will provide the proof of concept that p25 homing to tumors may be a novel and viable strategy for a new cancer therapy.
Sulamicerus stali  1868
Creators: name: Mozaffarian, Fariba
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Sulamicerus
Sulamicerus stali

description: Sulamicerus stali (Fieber, 1868) (Figs 39 and 55a–b)
Recorded damage and economic importance in the orchards of Iran: Previously known as a serious pest in pistachio gardens with severe economic damage, but as a secondary pest in recent years (Farahbakhsh 1961; Esmaili 1984; Behdad 1991; Kolyayee et al. 2012; Nourbakhsh et al. 2012)
Recorded damage in the orchards of other parts of the world: A pest on pistachio in Greece and Turkey which causes leaf whitening and blight of young panicles in large populations (Lodos & Kalkandelen 1982; Mourikis et al. 1998).
Recorded distribution in Iran: Southern slopes of Alborz to Persian Gulf (Mozaffarian & Wilson 2016).
Conclusion: Koliayee et al. (2012) mentioned the population size of the species, hence, its economic importance, has declined recently.
description: Published as part of Mozaffarian, Fariba, 2018, An Identification key to the species of Auchenorrhyncha of Iranian fauna recorded as pests in orchards and a review on the pest status of the species, pp. 475-501 in Zootaxa 4420 (4) on page 490, DOI: 10.11646/zootaxa.4420.4.2, http://zenodo.org/record/1455385
A novel strategy for expressing recombinant HCV glycoproteins in cell culture
Creators: name: Whidby, Jillian L.
Publisher: name: No Publisher Supplied
Year: 2012

description: Almost 4 million people are infected with hepatitis C virus (HCV) in the United States alone, with 170 million infected worldwide.  It is the leading cause of liver transplantation in the US.  Although infection is initially asymptomatic, HCV often leads to chronic liver disease, cirrhosis, and/or liver cancer.   Many cases are treatable with combination therapy (interferon, ribavirin, and new protease inhibitors), but efficacy is dependent on the infecting strain and there is currently no vaccine. Without more effective antiviral and immunological treatments, the Centers for Disease Control and Prevention (CDC) predicts that deaths due to HCV will double or triple in the next 15 to 20 years due to prolonged disease and continued spread. The high prevalence of infection, lack of highly effective HCV-specific inhibitors, and poor response rate to the current treatment underscore the importance of developing new therapeutic strategies.    The mechanism of viral entry is an important subject of study with respect to preventing and treating infection.  Two of the four HCV structural proteins, envelope 1 (E1) and envelope 2 (E2), heterodimerize on the surface of the virion.  Experimental evidence supports the roles of E1 and E2 in receptor binding, virus-cell fusion, and entry into the host cell.  These factors make E1 and E2 key determinants of pathogenicity and optimal targets of vaccine design.  We hypothesize that a thorough biophysical understanding of E2, as well as improvements in the available biochemical tools for the study of HCV E2 will provide a significant advancement in the understanding of viral infection.
Quebec and New Amsterdam to 1664
Creators: name: Weeks, Daniel J.
Publisher: name: No Publisher Supplied
Year: 2012

description: This study examines the techniques by which the French and Dutch secured preliminary information about the New World, claimed possession of territory in North America, and developed policies to secure possession against European competitors. It traces the development of French and Dutch colonial networks with an eye toward understanding the intentions of the colonizing powers. Finally, this study analyzes the dominant and significant flows of people, ideas, and goods along the colonial networks of the New France and New Netherland in order to map the interconnections of these colonies with the larger world. Tracing these flows reveals that the networks to which Quebec and New Amsterdam belonged were actually quite different, even though the dominant outflow—furs—was the same. The thesis of the dissertation is that for reasons related to European politics, French and Dutch policymakers adopted the principle that settlement was the only legal and practical means of possessing territory in the Americas and that it was the intention of the respective metropolitan governments to create agriculturally based settlement colonies in New France and New Netherland. Moreover, this study proposes that because of competition from other European nations, “linear” trading-post colonies were too weak to survive in North America, not only because they could not defend themselves, but also because they were not self-sustaining and did not become markets for manufactured goods from the metropole. This dissertation also asserts that although both New France and New Netherland made strides toward developing agriculturally based settlement colonies, the Dutch succeeded far better than the French because, as a node on a diffuse network, New Amsterdam was better able to attract settlers and connect to a wider range of markets than Quebec, which was more or less a node on a specific network. Finally, this study demonstrates that while both Quebec and New Amsterdam began to make the transition from simple primate centers on extractive dendritic/solar networks to gateway centers on more complex networks, New Amsterdam was far more advanced in this process and was rapidly facilitating the production of a new network of towns in its immediate hinterlands.