cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants
Creators: name: Antonescu, Cristina R.
name: Orlow, Irene
name: Engel, Lawrence S.
name: Ballman, Karla
name: O'Brien, Katie M.
name: McCall, Linda
name: DeMatteo, Ronald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Gastrointestinal stromal tumors (GISTs) are rare but treatable soft tissue sarcomas. Nearly all GISTs have somatic mutations in either the KIT or PDGFRA gene, but there are no known inherited genetic risk factors. We assessed the relationship between KIT/PDGFRA mutations and select deletions or single nucleotide polymorphisms (SNPs) in 279 participants from a clinical trial of adjuvant imatinib mesylate. Given previous evidence that certain susceptibility loci and carcinogens are associated with characteristic mutations, or “signatures” in other cancers, we hypothesized that the characteristic somatic mutations in the KIT and PDGFRA genes in GIST tumors may similarly be mutational signatures that are causally linked to specific mutagens or susceptibility loci. As previous epidemiologic studies suggest environmental risk factors such as dioxin and radiation exposure may be linked to sarcomas, we chose 208 variants in 39 candidate genes related to DNA repair and dioxin metabolism or response. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between each variant and 7 categories of tumor mutation using logistic regression. We also evaluated gene-level effects using the sequence kernel association test (SKAT). Although none of the association p-values were statistically significant after adjustment for multiple comparisons, SNPs in CYP1B1 were strongly associated with KIT exon 11 codon 557-8 deletions (OR = 1.9, 95% CI: 1.3-2.9 for rs2855658 and OR = 1.8, 95% CI: 1.2-2.7 for rs1056836) and wild type GISTs (OR = 2.7, 95% CI: 1.5-4.8 for rs1800440 and OR = 0.5, 95% CI: 0.3-0.9 for rs1056836). CYP1B1 was also associated with these mutations categories in the SKAT analysis (p = 0.002 and p = 0.003, respectively). Other potential risk variants included GSTM1, RAD23B and ERCC2. This preliminary analysis of inherited genetic risk factors for GIST offers some clues about the disease's genetic origins and provides a starting point for future candidate gene or gene-environment research.
Calculation and comparison of mooring forces on a single point moored buoy in an aquaculture system located in the German North Sea
Creators: name: Sykora, Jan
Publisher: name: Zenodo
Year: 2025

description: This bachelor thesis investigates the mooring forces acting on four different single-pointmoored buoys within an aquaculture system located at the research platformFINO3 in the German North Sea. Statistical analysis of site-specific environmental data,including wind, current, and wave parameters, was conducted to define 50-year extremeconditions. With these data, a simplified numerical model incorporating buoy dynamics andmooring line elasticity was developed.
Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage
Creators: name: Laskowitz, Daniel T.
name: Kranz, Peter G.
name: Phillips-Bute, Barbara
name: Roulhac-Wilson, Briana
name: Gray, Marisa C.
name: McDonagh, David L.
name: Sun, Wei
name: Umeano, Odera
name: James, Michael L.
name: Hailey, Claire E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundIntracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential effect of age and gender on outcomes after ICH has not been explored. This study was designed to test the hypothesis that age and gender interact to modify neurological outcomes after ICH.MethodsAdult patients admitted with spontaneous primary supratentorial ICH from July 2007 through April 2010 were assessed via retrospective analysis of an existing stroke database at Duke University. Univariate analysis of collected variables was used to compare gender and outcome. Unfavorable outcome was defined as discharge to hospice or death. Using multivariate regression, the combined effect of age and gender on outcome after ICH was analyzed. ResultsIn this study population, women were younger (61.1+14.5 versus 65.8+17.3 years, p=0.03) and more likely to have a history of substance abuse (35% versus 8.9%, p<0.0001) compared to men. Multivariable models demonstrated that advancing age had a greater effect on predicting discharge outcome in women compared to men (p=0.02). For younger patients, female sex was protective; however, at ages greater than 60 years, female sex was a risk factor for discharge to hospice or death.ConclusionWhile independently associated with discharge to hospice or death after ICH, the interaction effect between gender and age demonstrated significantly stronger correlation with early outcome after ICH in a single center cohort. Prospective study is required to verify these findings.
MPEC 2023-R52 : 2023 RC1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 RC1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 2 of Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
Creators: name: Simonds, Megan M.
name: Sullivan, Kathleen E.
name: Brescia, AnneMarie C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Supplemental Table 2.
AGU_SuppInfo-Ma et al., 2022-JGR-for review
Creators: name: Ma, Yiming
Publisher: name: figshare
Year: 2022
Subjects: subject: 40406 Magnetism and Palaeomagnetism
subject: FOS: Earth and related environmental sciences
subject: 40303 Geochronology
subject: Mineralogy

description: supporting information file of Ma et al., 2022-JGR-for review
Survey # 2065(I)(II)
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Sense of personal efficacy (1); political violence (4); vocabulary (1); satisfaction with Chancellor Brandt’s policies (1); hospitals (6); satisfaction with Foreign Minister Scheel’s policies (1); satisfaction with government (10); dreams (1); books (2); relations between West and East Germany (6); environmental protection (2); parenting (3); news (1); prescription glasses (21); TV (6); sexual freedoms (2); relations between Germany and Eastern Europe (10); entrepreneurs (2); economic conditions (2); tax reform (5); Berlin (2); Catholicism (3); attitudes toward Germany (1); women’s clothing (4); gas stations (10); proverbs (1).
Optimización del proceso de deshidratación del higo (Ficus Carica L.) variedad Kadota, utilizando la metodología Taguchi /
Creators: name: Lugo Ibarra, Erica Esther.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Método Taguchi (Control de calidad)||Higo||Deshidratación||ProcesoIngeniería||Tesis.
subject: TS156 L83 2008

description: México ocupa el tercer lugar de importancia en la producción de higo en América, con más de 6000 toneladas (t) anuales.
Survey # 2066
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Inflation (7); Economic productivity (2); household chores (2); satisfaction with Chancellor Brandt’s policies (1); attitudes toward politicians (2); foreign policy (4); political knowledge (1); relations between West and East Germany (1); potential new elections (1); satisfaction with Foreign Minister Scheel’s policies (1); attitudes toward journalists and commentators (2); celebrities (2); personal financial situation (1); savings (1); German history (2); sources of discontent (1); political priorities (1); attitudes toward different countries (1); women’s clothing (5); socialism (1); attitudes toward political parties (1); pornography (2); prescription glasses (4); attitudes toward government (1); relations between Germany and Eastern Europe (3); Berlin (1); most attractive personal qualities (2); cigarette brands (2); smoking habits (1); housing situation (5); expectations for unemployment (1); student protests (2); banks (3); federalism (1); driving habits (6); freedom of speech (6); trade unions (1); happiness (1); sleeping habits (1).
Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Creators: name: Otero, Ronny M.
name: Rivers, Emanuel P.
name: Cairns, Charles B.
name: Zaas, Aimee K.
name: Cyr, Derek D.
name: van Velkinburgh, Jennifer C.
name: Fowler, Vance G.
name: Zhang, Yurong
name: Glickman, Seth W.
name: Langley, Raymond J.
name: Veldman, Tim
name: Kingsmore, Stephen F.
name: Ahn, Sun Hee
name: Ginsburg, Geoffrey S.
name: Woods, Christopher W.
name: Tsalik, Ephraim L.
name: Lucas, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host’s inflammatory response to the pathogen represents a potential tool to improve upon current diagnostics. The hypothesis of this study is that the host responds differently to S. aureus than to E. coli infection in a quantifiable way, providing a new diagnostic avenue. This study uses Bayesian sparse factor modeling and penalized binary regression to define peripheral blood gene-expression classifiers of murine and human S. aureus infection. The murine-derived classifier distinguished S. aureus infection from healthy controls and Escherichia coli-infected mice across a range of conditions (mouse and bacterial strain, time post infection) and was validated in outbred mice (AUC>0.97). A S. aureus classifier derived from a cohort of 94 human subjects distinguished S. aureus blood stream infection (BSI) from healthy subjects (AUC 0.99) and E. coli BSI (AUC 0.84). Murine and human responses to S. aureus infection share common biological pathways, allowing the murine model to classify S. aureus BSI in humans (AUC 0.84). Both murine and human S. aureus classifiers were validated in an independent human cohort (AUC 0.95 and 0.92, respectively). The approach described here lends insight into the conserved and disparate pathways utilized by mice and humans in response to these infections. Furthermore, this study advances our understanding of S. aureus infection; the host response to it; and identifies new diagnostic and therapeutic avenues.
Magnetic-Field Amplification in the Thin X-ray Rims of SN1006
Creators: name: Ressler, Sean M.
name: Katsuda, Satoru
name: Reynolds, Stephen P.
name: Long, Knox S.
name: Petre, Robert
name: Williams, Brian J.
name: Winkler, P. Frank
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to 100 $μ$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \propto E^μ$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FWHM $\propto E^{m_E}_γ$. Filament widths in SN1006 decrease with energy; $m_E \sim -0.3$ to $-0.8$, implying magnetic field amplification by factors of 10 to 50, above the factor of 4 expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of $D$ on energy ($μ\ge 1$).
description: Accepted by ApJ, 49 pages, 10 figures
Additional file 2 of Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1
Creators: name: You, Yungmi
name: Doi, Yuki
name: Maeda, Norifumi
name: Masuo, Shunsuke
name: Takeshita, Norio
name: Takaya, Naoki
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Supplementary Table S1. Bacteria isolated from grassland weed rhizosphere.
Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate
Creators: name: Liu, Fangqun
name: Tang, Jie
name: Yin, Jiye
name: Ouyang, Dongsheng
name: Gao, Lichen
name: Huang, Zhengyu
name: He, Yijing
name: Chen, Xiaoping
name: Liu, Zhaoqian
name: Zhou, Honghao
name: Zhang, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: This study investigated the effects of pregnane X receptor (PXR/NR1I2) and CYP2B6 genetic variants on sodium ferulate (SF)-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered with and without SF pretreatment for 14 days in 33 healthy subjects. The area under the time-concentration curve (AUC) ratio of AUC_hyd (AUC(0-∞) of hydroxybupropion)/AUC_bup (AUC(0-∞) of bupropion) represents the CYP2B6 hydroxylation activity, which was significantly lower in CYP2B6*6 carriers (NR1I2 TGT noncarriers or carriers) than in noncarriers in both the basal and SF-induced states (p-value<0.05). AUC ratio and AUC_hyd of NR1I2 -24113AA variant were markedly lower than GA and GG genotypes (7.5±2.1 versus 14.5±3.3 and 20.6±1.1, and 8873±1431 versus 14,504±2218 and 17,586±1046) in the induced states. However, -24020(-)/(-) variant didn't show significant difference in the induction of CYP2B6 hydroxylation activity by SF compared with other -24020[GAGAAG]/(-) genotypes. NR1I2 TGT haplotype (-25385T+g.7635G+g.8055T) carriers exhibited a significantly decreased AUC ratio, compared with TGT noncarriers, in the basal states (7.6±1.0 versus 9.7±1.0), while this result wasn't observed in CYP2B6*6 noncarriers. Moreover, individuals with complete mutation-type [CYP2B6*6/*6+NR1I2 TGT+ -24113AA+ -24020 (-)/(-)] showed even lower percent difference of AUC ratio (8.7±1.2 versus 39.5±8.2) than those with complete wild-type. In conclusion, it is suggested that NR1I2 variants decrease the bupropion hydroxylation induced by SF treatment, particularly in CYP2B6*6 carriers.
Survey # 2067
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Hopes and fears (1); satisfaction with previous year (1); expenditures for Christmas presents (1); Chancellor Brandt job performance (1); most important issues in Germany today (1); future unemployment rate (1); inflation (1); income at different socioeconomic levels (3); interest in TV programs (1); attitudes toward rural conservation (3); attitudes toward nuclear energy (5); awareness of nuclear energy (1); water pollution (6); air pollution (3); cigarette brands (1); former German territories (1); interest in environmental issues (3); attitudes toward environmental issues (7); game brands (1); candle brands (2); relations between Germany and Eastern Europe (6); committee for environmental protection (1); resources for environmental protection (2); smoking habits (2); CSU/FDP scandal (3); writing poetry (2); attitudes toward technology (1).
Transferring entangled states through spin chains by boundary-state multiplets
Creators: name: Lorenz, Peter
name: Stolze, Joachim
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum spin chains may be used to transfer quantum states between elements of a quantum information processing device. A scheme discovered recently \cite{BFR+12} was shown to have favorable transfer properties for ingle-qubit states even in the presence of built-in static disorder caused by manufacturing errors. We extend that scheme in a way suggested already in \cite{BFR+12} and study the transfer of the four Bell states which form a maximally entangled basis in the two-qubit Hilbert space. We show that perfect transfer of all four Bell states separately and of arbitrary linear combinations may be achieved for chains with hundreds of spins. For simplicity we restrict ourselves to systems without disorder.
description: 5 pages, 6 figures
Desarrollo de un instrumento electrónico portable para diagnóstico temprano de trombosis venosa profunda empleando algoritmos de aprendizaje automático
Creators: name: Contreras Lujan, Eduardo Enrique.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Ingeniería||Tesis y disertaciones académicas||Algoritmos genéticos||Enseñanza con ayuda de computadoras.
subject: QA402.5 C65 2022

description: En este trabajo de tesis se presenta a la Trombosis Venosa Profunda (TVP) que es una enfermedad la cual debe ser diagnosticada rápidamente, en consecuencia puede desencadenar la muerte de los pacientes.
Warmth or Competence? The Influence of Gender on the Receiver of Social Support's First Thought
Creators: name: Theodore, Jessica
name: Weiss, Amira
name: Borkovic, Lidia
name: Sidler, Tatiana
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: In this study we want to examine whether receivers of social support's first thought is focused on warmth or competence depending on the gender of the expresser.
Genetic Variation and Reproductive Timing: African American Women from the Population Architecture Using Genomics and Epidemiology (PAGE) Study
Creators: name: Crawford, Dana C.
name: Young, Alicia
name: Matise, Tara C.
name: Fernández-Rhodes, Lindsay
name: Haiman, Christopher A.
name: Franceschini, Nora
name: Malinowski, Jennifer
name: Spencer, Kylee L.
name: Carty, Cara L.
name: Wilkens, Lynne
name: Cheng, Iona
name: Buyske, Steven
name: Ritchie, Marylyn D.
name: Rajkovic, Aleksandar
name: Hindorff, Lucia A.
name: Brennan, Kathleen
name: Park, Amy
name: Carlson, Christopher S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the reproductive lifespan in women. Their timing is associated with various diseases, including cancer and cardiovascular disease. Genome-wide association studies have identified several genetic variants associated with either AM or ANM in populations of largely European or Asian descent women. The extent to which these associations generalize to diverse populations remains unknown. Therefore, we sought to replicate previously reported AM and ANM findings and to identify novel AM and ANM variants using the Metabochip (n = 161,098 SNPs) in 4,159 and 1,860 African American women, respectively, in the Women’s Health Initiative (WHI) and Atherosclerosis Risk in Communities (ARIC) studies, as part of the Population Architecture using Genomics and Epidemiology (PAGE) Study. We replicated or generalized one previously identified variant for AM, rs1361108/CENPW, and two variants for ANM, rs897798/BRSK1 and rs769450/APOE, to our African American cohort. Overall, generalization of the majority of previously-identified variants for AM and ANM, including LIN28B and MCM8, was not observed in this African American sample. We identified three novel loci associated with ANM that reached significance after multiple testing correction (LDLR rs189596789, p = 5×10−08; KCNQ1 rs79972789, p = 1.9×10−07; COL4A3BP rs181686584, p = 2.9×10−07). Our most significant AM association was upstream of RSF1, a gene implicated in ovarian and breast cancers (rs11604207, p = 1.6×10−06). While most associations were identified in either AM or ANM, we did identify genes suggestively associated with both: PHACTR1 and ARHGAP42. The lack of generalization coupled with the potentially novel associations identified here emphasize the need for additional genetic discovery efforts for AM and ANM in diverse populations.
MPEC 2023-R53 : 2023 RD1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 RD1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Analysis of Named Entity Recognition and Linking for Tweets
Creators: name: Derczynski, Leon
name: Maynard, Diana
name: Rizzo, Giuseppe
name: van Erp, Marieke
name: Gorrell, Genevieve
name: Troncy, Raphaël
name: Petrak, Johann
name: Bontcheva, Kalina
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Applying natural language processing for mining and intelligent information access to tweets (a form of microblog) is a challenging, emerging research area. Unlike carefully authored news text and other longer content, tweets pose a number of new challenges, due to their short, noisy, context-dependent, and dynamic nature. Information extraction from tweets is typically performed in a pipeline, comprising consecutive stages of language identification, tokenisation, part-of-speech tagging, named entity recognition and entity disambiguation (e.g. with respect to DBpedia). In this work, we describe a new Twitter entity disambiguation dataset, and conduct an empirical analysis of named entity recognition and disambiguation, investigating how robust a number of state-of-the-art systems are on such noisy texts, what the main sources of error are, and which problems should be further investigated to improve the state of the art.
description: 35 pages, accepted to journal Information Processing and Management
Additional file 3 of Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
Creators: name: Simonds, Megan M.
name: Sullivan, Kathleen E.
name: Brescia, AnneMarie C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Supplemental Table 3.
Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry
Creators: name: Passarelli, Michael N.
name: Hopper, John L.
name: Carracedo, Angel
name: Le Marchand, Loic
name: Redondo, Carmen M.
name: Conti, David V.
name: Baron, John A.
name: Gallinger, Steven
name: Ahnen, Dennis J.
name: Jenkins, Mark A.
name: Jiang, Xuejuan
name: Lindor, Noralane M.
name: Newcomb, Polly A.
name: Paredes Cotoré, Jesus P.
name: Gago-Dominguez, Manuela
name: Potter, John D.
name: Vandenberg, David
name: Martínez, María E.
name: Haile, Robert W.
name: Castelao, J. Esteban
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundRecent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry.Materials and Methods23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression.ResultsAmong the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12–1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70–0.92) were associated with risk of colorectal cancer. These associations were similar among the population- and the clinic-based families, though they were significant only among the former. Marginally significant differences in the SNP-colorectal cancer associations were observed by use of nonsteroidal anti-inflammatory drugs, cigarette smoking, body mass index, and history of polyps.ConclusionsSMAD7 SNPs were associated with colorectal cancer risk in the Colon Cancer Family Registry. There was evidence suggesting that the association between rs12953717 and colorectal cancer risk may be modified by factors such as smoking and use of nonsteroidal anti-inflammatory drugs.
Survey # 2069
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Beliefs about state of the world (1); moon landing (1); beverage preferences (1); Chancellor Brandt job performance (1); Foreign Minister Scheel job performance (1); awareness of politicians (1); attitudes toward politicians (1); economic policy priorities (1); wine brands (10); craft materials brands (10); new traffic rules (6); price controls (4); environment protection (3); death penalty (3); relations between Germany and Eastern Europe (7); prices for agricultural goods (1); sparkling wine brands (2); carnival (3); comparison of CDU and SPD (1); drinking habits (2); salary negotiations with unions (1); tax increases (2); cigarette brands (9); divisions within SPD (3); mail on Sundays (2); attitudes toward abortion (1); Baader-Meinhof terrorism (2); smoking habits (1); attitudes toward socialism (1); attitudes toward misappropriating workplace materials (2); telling jokes (1).
Survey # 2080
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Car preferences (1); Olympics (5); consumption patterns (18); tissue brands (2); satisfaction with federal government (2); garden gnomes (2); most important political problems (1); TV ownership (2); commercials on TV and radio (26); gas station promotions (2); driving habits (2); smoking habits (1); refugees (3); Minister of Home Affairs Genscher job performance (1); interest in politics (1); Foreign Minister Scheel job performance (1); radio stations (6); relations between Germany and Eastern Europe (9); Latin class in school (1); current worries (1); movie theaters (2); Greek class in school (1); newspapers (4); sparkling wine brands (3); preferred women’s clothing styles (5); TV programs (3); consumption preferences (1); pet ownership (1); thriftiness (1).
Diseño de un controlador para un dispositivo de acoplamiento de carga par adquirir imágenes en un telescopio /
Creators: name: Colorado Ortìz, Enrique.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Fotografía astronómica||CCD (Dispositivo fotográfico)||Dispositivos||Telescopio||Ingeniería||Tesis.
subject: QB121 C65 2005

description: Este trabajo describe el diseño de un sistema electrónico para la adquisición de imágenes de uso científico utilizando como sensor un dispositivo de acoplamiento de cargas comúnmente llamado CCD.
Additional file 4 of Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
Creators: name: Simonds, Megan M.
name: Sullivan, Kathleen E.
name: Brescia, AnneMarie C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Supplemental Table 4.
Ultra-high brilliance multi-MeV $γ$-ray beam from non-linear Thomson scattering
Creators: name: Sarri, G.
name: Corvan, D. J.
name: Schumaker, W.
name: Cole, J.
name: Di Piazza, A.
name: Ahmed, H.
name: Harvey, C.
name: Keitel, C. H.
name: Krushelnick, K.
name: Mangles, S. P. D.
name: Najmudin, Z.
name: Symes, D.
name: Thomas, A. G. R.
name: Yeung, M.
name: Zhao, Z.
name: Zepf, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We report on the generation of a narrow divergence ($θ\approx 2.5$ mrad), multi-MeV ($E_\text{MAX} = 18$ MeV) and ultra-high brilliance ($\approx 2\times10^{19}$ photons s$^{-1}$ mm$^{-2}$ mrad $^{-2}$ 0.1\% BW) $γ$-ray beam from the scattering of an ultra-relativistic laser-wakefield accelerated electron beam in the field of a relativistically intense laser (dimensionless amplitude $a_0\approx2$). The spectrum of the generated $γ$-ray beam is measured, with MeV resolution, seamlessly from 6 MeV to 18 MeV, giving clear evidence of the onset of non-linear Thomson scattering. The photon source has the highest brilliance in the multi-MeV regime ever reported in the literature.
Structural, elastic, thermal, and electronic response of small-molecule-loaded metal organic framework materials
Creators: name: Canepa, Pieremanuele
name: Tan, Kui
name: Du, Yingjie
name: Lu, Hongbing
name: Chabal, Yves J.
name: Thonhauser, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We combine infrared spectroscopy, nano-indentation measurements, and \emph{ab initio} simulations to study the evolution of structural, elastic, thermal, and electronic responses of the metal organic framework MOF-74-Zn when loaded with H$_2$, CO$_2$, CH$_4$, and H$_2$O. We find that the molecular adsorption in this MOF triggers remarkable responses in all of these properties of the host material, with specific signatures for each of the guest molecules. With this comprehensive study we are able to clarify and correlate the underlying mechanisms regulating these responses with changes of the physical and chemical environment. Our findings suggest that metal organic framework materials in general, and MOF-74-Zn in particular, can be very promising materials for novel transducers and sensor applications, including highly selective small-molecule detection in gas mixtures.
Genome-Wide Quantitative Identification of DNA Differentially Methylated Sites in Arabidopsis Seedlings Growing at Different Water Potential
Creators: name: Jones, Alan M.
name: Colaneri, Alejandro C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundIn eukaryotes, the combinatorial usage of cis-regulatory elements enables the assembly of composite genetic switches to integrate multifarious, convergent signals within a single promoter. Plants as sessile organisms, incapable of seeking for optimal conditions, rely on the use of this resource to adapt to changing environments. Emerging evidence suggests that the transcriptional responses of plants to stress are associated with epigenetic processes that govern chromatin accessibility. However, the extent at which specific chromatin modifications contribute to gene regulation has not been assessed.Methodology/Principal FindingsIn the present work, we combined methyl-sensitive-cut counting and RNA-seq to follow the transcriptional and epigenetic response of plants to simulated drought. Comprehensive genome wide evidence supports the notion that the methylome is widely reactive to water potential. The predominant changes in methylomes were loci in the promoters of genes encoding for proteins suited to cope with the environmental challenge.Conclusion/SignificanceThese selective changes in the methylome with corresponding changes in gene transcription suggest drought sets in motion an instructive mechanism guiding epigenetic machinery toward specific effectors genes.
Survey # 2085
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Olympics (6); current worries (4); brandy (4); German federal parliament job performance (1); Chancellor Brandt job performance (1); Foreign Minister Scheel job performance (1); German Communist Party (4); national socialist party (1); attitudes toward Hitler (1); labels on clothing (3); prospective federal vote choice (3); European currency union (2); kissing women’s hands in greeting (1); privacy (1); most important political problems (1); attitudes toward centralization of power (2); relations between West and East Germany (2); confidence in Minister Schmidt’s economic policy (1); attitudes toward members of parliament (5); current German constitution (1); satisfaction with federal government (2); working on Saturdays (3); cigarette brands (6); smoking habits (1); beliefs about upcoming election outcome (1); attitudes toward party membership (1); TV ownership (2); interest in politics (1); divisions within SPD (2); interest in sports (1).
Survey # 2089
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Hopes and fears (1); satisfaction with previous year (1); Christmas presents (2); “new Christmas” initiative/buying Christmas trees (2); smoking ban (3); smoking habits (1); recent federal election (7); laundry detergent brands (20); watch brands (4); German position in the world (2); awareness of politicians (5); relations between West and East Germany (2); yogurt brands (4); attitudes toward Helmut Schmidt (1); attitudes toward conditions in German prisons (1); anti-communist advertisements (3); women’s clothing (7); voting in recent federal election (8); duvets (14); caricature (2); socialism in Germany (5); political programs on TV (2); interest in politics (1); Christmas carols (2); fitness (3).
Diseño y construcción de un controlador de semáforo inteligente con comunicación inalámbrica
Creators: name: Navarro Espinoza, Alfonso.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Ingeniería||Tesis y disertaciones académicas||Microcontroladores||Diseño y construcción.
subject: TK7895.E42 N38 2022

description: En este trabajo de tesis de maestría, se presenta el diseño y desarrollo de un prototipo de controlador de semáforo inteligente basado en un microcontrolador STM32F103.
Contribución de los pastos marinos a la concentración de carbono orgánico disuelto en Bahía San Quintín (Baja California, México) :
Creators: name: Camalich Carpizo, Jaime Manuel.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Pastos marinos||Zostera marina||Pastos marinos||San Quintin, Bahía de Baja California||Carbono||Oceanografía costera||Tesis.
subject: QK495.A14 C35 2006

description: Estudios recientes en Bahía de San Quintín señalan que la concentración de carbono orgánico disuelto (COD) incrementa desde el oceáno hacia el brazo este, área en donde la vegetación de marisma y las praderas de pastos marinos (Zostera marina) son abundantes.
Cutting Tool Path Modification to Uniform Scallop- Height in Three-Axis Milling Operations
Creators: name: Soori, Mohsen
name: Arezoo, Behrooz
Publisher: name: figshare
Year: 2022
Subjects: subject: 91001 CAD/CAM Systems
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Scallop height, which is the uncut amount of workpiece materials in metal cutting paths, has an impact on the surface condition of manufactured products. To increase accuracy and surface quality of machined parts, the scallop height should be analyzed in order to be minimized. In this study, a virtual machining system is created to produce uniform scallop height throughout free form surface end milling. Machined surfaces are analyzed by the developed system in order to obtain the curvature of free form surfaces. Then, the machined surfaces are divided to the at, concave and convex surfaces in order to analyze and modify the cutting tool paths along milling operations. The machining parameters of step over, feed rate and spindle speed are modi ed in order to obtain uniform scallop height during milling operations of free form surfaces. As a result, the modi ed cutting tool paths can generate the uniform scallop height in order to increase surface quality of machined free form surfaces. To enhance the process of component manufacturing utilizing machining operations, the study's produced virtual machining system can raise the productivity as well as the accuracy of machined free from surfaces.
MPEC 2023-R54 : 2023 RE1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 RE1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Glabellar flap as treatment in nasal resection of basal cell carcinoma. A case report
Creators: name: Marcela Rojas Hurtado M.D.
name: José Luis Villarreal Salgado M.D.
name: Miroslava Villarreal Contreras M.D.
name: Gerardo Salvador Rea Martinez M.D.
name: Samanta Cristina Arce Oliva M.D.
name: José Maria Martinez Rodriguez M.D.
name: Itzel Arelí Murillo Moreno M.D.
name: Carlos Enrique Luna Guerrero M.D.
name: Claudia Verónica Elizabeth Vargas Hernández M.D.
Publisher: name: Zenodo
Year: 2023

description: Background
Basal cell carcinoma is the most common type of skin cancer, occurring mainly in the face and neck region. The main risk factor is related to exposure to UVB radiation waves, related to the intensity and duration of sun exposure. The most common picture is a pearly elevation with translucent margins, being more common in the nose and neck. A biopsy is necessary as well as total resection with margins of 2-5mm.
 
Keywords: Basal cell carcinoma, Head and neck reconstruction.
Survey # 2095
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Expectations for economic conditions in Germany (1); living preferences of elderly (2); illness (1); attitudes toward US (6); inflation (2); attitudes toward people from the Rhineland (3); nuclear energy (4); electricity needs (3); environmental protection (2); interest group FONTANA (2); satisfaction with Foreign Minister Scheel’s policies (1); satisfaction with Chancellor Brandt’s policies (1); magazines (2); satisfaction with federal government (3); sparkling wine brands (2); CDU leadership (3); German national holiday (3); commercials on TV (3); vaccinations (1); cigarette brands (3); relations between Germany and Eastern Europe (3); price controls (2); magazines (6); socialism (1); paperback books (3); greeting cards (2); smoking habits (1); most important political problems (1); consumption of alcoholic beverages (1); interest in politics (1); loneliness (1); women’s clothing (1); happiness (2); trademarks (1); assisted suicide (1).
Diversity of chemistry and excitation conditions in the high-mass star forming complex W33
Creators: name: Immer, K.
name: Galván-Madrid, R.
name: König, C.
name: Liu, H. B.
name: Menten, K. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The object W33 is a giant molecular cloud that contains star forming regions at various evolutionary stages from quiescent clumps to developed H II regions. Since its star forming regions are located at the same distance and the primary material of the birth clouds is probably similar, we conducted a comparative chemical study to trace the chemical footprint of the different phases of evolution. We observed six clumps in W33 with the Atacama Pathfinder Experiment (APEX) telescope at 280 GHz and the Submillimeter Array (SMA) at 230 GHz. We detected 27 transitions of 10 different molecules in the APEX data and 52 transitions of 16 different molecules in the SMA data. The chemistry on scales larger than $\sim$0.2 pc, which are traced by the APEX data, becomes more complex and diverse the more evolved the star forming region is. On smaller scales traced by the SMA data, the chemical complexity and diversity increase up to the hot core stage. In the H II region phase, the SMA spectra resemble the spectra of the protostellar phase. Either these more complex molecules are destroyed or their emission is not compact enough to be detected with the SMA. Synthetic spectra modelling of the H$_{2}$CO transitions, as detected with the APEX telescope, shows that both a warm and a cold component are needed to obtain a good fit to the emission for all sources except for W33 Main1. The temperatures and column densities of the two components increase during the evolution of the star forming regions. The integrated intensity ratios N$_{2}$H$^{+}$(3$-$2)/CS(6$-$5) and N$_{2}$H$^{+}$(3$-$2)/H$_{2}$CO(4$_{2,2}$$-$3$_{2,1}$) show clear trends as a function of evolutionary stage, luminosity, luminosity-to-mass ratio, and H$_{2}$ peak column density of the clumps and might be usable as chemical clocks.
description: 66 pages, 28 figures, 8 tables, accepted for publication at A&A
Survey # 2096
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Attitudes toward work (6); leisure time (1); sense of freedom (1); gas stations (2); proposed orthography reforms (2); cigarette brands (4); mood (6); sick days (1); work environment (1); attitudes toward politicians (5); dangers associated with flea markets (3); chocolate brands (2); purpose in life (3); satisfaction with life (7); sleeping habits (3); magazine brands (1); air traffic controllers’ strike (3); car ownership (3); social trust (1); brands associated with locations (4); celebrities (2); smoking habits (1); health supplements/medication (3); socialism in Germany (3); tax increase (1); corruption scandal concerning Steiner and Wienand (7); interest in politics (1); recent experiences (1).
Genotype-Based Ancestral Background Consistently Predicts Efficacy and Side Effects across Treatments in CATIE and STAR*D
Creators: name: van den Oord, Edwin J. C. G.
name: Clark, Shaunna L.
name: Souza, Renan P.
name: Åberg, Karolina
name: McClay, Joseph L.
name: Adkins, Daniel E.
name: Sullivan, Patrick F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Only a subset of patients will typically respond to any given prescribed drug. The time it takes clinicians to declare a treatment ineffective leaves the patient in an impaired state and at unnecessary risk for adverse drug effects. Thus, diagnostic tests robustly predicting the most effective and safe medication for each patient prior to starting pharmacotherapy would have tremendous clinical value. In this article, we evaluated the use of genetic markers to estimate ancestry as a predictive component of such diagnostic tests. We first estimated each patient’s unique mosaic of ancestral backgrounds using genome-wide SNP data collected in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) (n = 765) and the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) (n = 1892). Next, we performed multiple regression analyses to estimate the predictive power of these ancestral dimensions. For 136/89 treatment-outcome combinations tested in CATIE/STAR*D, results indicated 1.67/1.84 times higher median test statistics than expected under the null hypothesis assuming no predictive power (p<0.01, both samples). Thus, ancestry showed robust and pervasive correlations with drug efficacy and side effects in both CATIE and STAR*D. Comparison of the marginal predictive power of MDS ancestral dimensions and self-reported race indicated significant improvements to model fit with the inclusion of MDS dimensions, but mixed evidence for self-reported race. Knowledge of each patient’s unique mosaic of ancestral backgrounds provides a potent immediate starting point for developing algorithms identifying the most effective and safe medication for a wide variety of drug-treatment response combinations. As relatively few new psychiatric drugs are currently under development, such personalized medicine offers a promising approach toward optimizing pharmacotherapy for psychiatric conditions.
Spectra of Random Stochastic Matrices and Relaxation in Complex Systems
Creators: name: Kuehn, Reimer
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We compute spectra of large stochastic matrices $W$, defined on sparse random graphs, where edges $(i,j)$ of the graph are given positive random weights $W_{ij}>0$ in such a fashion that column sums are normalized to one. We compute spectra of such matrices both in the thermodynamic limit, and for single large instances. The structure of the graphs and the distribution of the non-zero edge weights $W_{ij}$ are largely arbitrary, as long as the mean vertex degree remains finite in the thermodynamic limit and the $W_{ij}$ satisfy a detailed balance condition. Knowing the spectra of stochastic matrices is tantamount to knowing the complete spectrum of relaxation times of stochastic processes described by them, so our results should have many interesting applications for the description of relaxation in complex systems. Our approach allows to disentangle contributions to the spectral density related to extended and localized states, respectively, allowing to differentiate between time-scales associated with transport processes and those associated with the dynamics of local rearrangements.
description: 4 pages, 2 figures
Additional file 5 of Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
Creators: name: Simonds, Megan M.
name: Sullivan, Kathleen E.
name: Brescia, AnneMarie C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Supplemental Table 5.